                         SEQUENCE LISTING

<110>  CureVac AG

<120>  mRNA containing composition for treatment of tumor diseases

<130>  CU01P175WO-1

<160>  10071

<210>  1
<211>  1815
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R1328 coding for the mouse IL-12 protein

<400>  1
gggagaaagc uuaccaugug cccccagaag cugaccauca gcugguucgc caucgugcuc       60

cuggucuccc cgcugauggc caugugggag cucgagaagg acguguacgu ggucgaggug      120

gacuggaccc ccgacgcgcc cggcgagacg gugaaccuga ccugcgacac ccccgaggag      180

gacgacauca ccuggacgag cgaccagcgg cacgggguca ucggcuccgg gaagacccug      240

accaucaccg ugaaggaguu ccucgacgcc ggccaguaca cgugccacaa gggcggcgag      300

acccugagcc acucccaccu gcuccugcac aagaaggaga acgggaucug gagcaccgag      360

auccugaaga acuucaagaa caagaccuuc cucaagugcg aggccccgaa cuacuccggg      420

cgcuucacgu gcagcuggcu ggugcagcgg aacauggacc ugaaguucaa caucaagucc      480

agcuccagcu cccccgacag ccgcgccguc accugcggca uggccucccu cagcgcggag      540

aaggugaccc uggaccagcg ggacuacgag aaguacuccg ugagcugcca ggaggacguc      600

accugcccca cggccgagga gacccugccc aucgagcucg cccuggaggc ccgccagcag      660

aacaaguacg agaacuacuc caccagcuuc uucauccggg acaucaucaa gccggacccc      720

cccaagaacc ugcagaugaa gccccucaag aacagccagg uggagguguc cugggaguac      780

ccggacagcu gguccacccc gcacagcuac uucucccuga aguucuucgu ccgcauccag      840

cggaagaagg agaagaugaa ggagacggag gaggggugca accagaaggg cgcguuccug      900

guggagaaga ccagcaccga ggugcagugc aagggcggga acgucugcgu gcaggcccag      960

gaccgguacu acaacuccag cugcuccaag ugggccugcg ugcccugccg gguccgcagc     1020

cgcgugaucc ccgucagcgg cccggcccgg ugccuguccc agagccgcaa ccugcucaag     1080

accacggacg acauggugaa gaccgcccgg gagaagcuga agcacuacuc cugcaccgcc     1140

gaggacaucg accacgagga caucacccgc gaccagacga gcacccugaa gaccugccuc     1200

ccccuggagc ugcacaagaa cgaguccugc cucgccaccc gggagacgag cuccaccacc     1260

cgcgggagcu gccugccgcc ccagaagacc ucccugauga ugacgcucug ccugggcagc     1320

aucuacgagg accugaagau guaccagacc gaguuccagg cgaucaacgc cgcccuccag     1380

aaccacaacc accagcagau cauccuggac aaggggaugc ugguggccau cgacgagcuc     1440

augcaguccc ugaaccacaa cggcgagacc cugcggcaga agccgcccgu cggggaggcg     1500

gaccccuacc gcgugaagau gaagcucugc auccugcugc acgccuucag cacccgggug     1560

gucacgauca accgcgugau gggcuaccuc uccagcgccg acuacaagga cgacgacgac     1620

aagugaggac uaguuauaag acugacuagc ccgaugggcc ucccaacggg cccuccuccc     1680

cuccuugcac cgagauuaau aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaauauucc cccccccccc cccccccccc ccccccccuc     1800

uagacaauug gaauu                                                      1815


<210>  2
<211>  1857
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R491 coding for the Photinus pyralis luciferase protein

<400>  2
gggagaaagc uugaggaugg aggacgccaa gaacaucaag aagggcccgg cgcccuucua       60

cccgcuggag gacgggaccg ccggcgagca gcuccacaag gccaugaagc gguacgcccu      120

ggugccgggc acgaucgccu ucaccgacgc ccacaucgag gucgacauca ccuacgcgga      180

guacuucgag augagcgugc gccuggccga ggccaugaag cgguacggcc ugaacaccaa      240

ccaccggauc guggugugcu cggagaacag ccugcaguuc uucaugccgg ugcugggcgc      300

ccucuucauc ggcguggccg ucgccccggc gaacgacauc uacaacgagc gggagcugcu      360

gaacagcaug gggaucagcc agccgaccgu gguguucgug agcaagaagg gccugcagaa      420

gauccugaac gugcagaaga agcugcccau cauccagaag aucaucauca uggacagcaa      480

gaccgacuac cagggcuucc agucgaugua cacguucgug accagccacc ucccgccggg      540

cuucaacgag uacgacuucg ucccggagag cuucgaccgg gacaagacca ucgcccugau      600

caugaacagc agcggcagca ccggccugcc gaagggggug gcccugccgc accggaccgc      660

cugcgugcgc uucucgcacg cccgggaccc caucuucggc aaccagauca ucccggacac      720

cgccauccug agcguggugc cguuccacca cggcuucggc auguucacga cccugggcua      780

ccucaucugc ggcuuccggg ugguccugau guaccgguuc gaggaggagc uguuccugcg      840

gagccugcag gacuacaaga uccagagcgc gcugcucgug ccgacccugu ucagcuucuu      900

cgccaagagc acccugaucg acaaguacga ccugucgaac cugcacgaga ucgccagcgg      960

gggcgccccg cugagcaagg aggugggcga ggccguggcc aagcgguucc accucccggg     1020

cauccgccag ggcuacggcc ugaccgagac cacgagcgcg auccugauca cccccgaggg     1080

ggacgacaag ccgggcgccg ugggcaaggu ggucccguuc uucgaggcca agguggugga     1140

ccuggacacc ggcaagaccc ugggcgugaa ccagcggggc gagcugugcg ugcgggggcc     1200

gaugaucaug agcggcuacg ugaacaaccc ggaggccacc aacgcccuca ucgacaagga     1260

cggcuggcug cacagcggcg acaucgccua cugggacgag gacgagcacu ucuucaucgu     1320

cgaccggcug aagucgcuga ucaaguacaa gggcuaccag guggcgccgg ccgagcugga     1380

gagcauccug cuccagcacc ccaacaucuu cgacgccggc guggccgggc ugccggacga     1440

cgacgccggc gagcugccgg ccgcgguggu ggugcuggag cacggcaaga ccaugacgga     1500

gaaggagauc gucgacuacg uggccagcca ggugaccacc gccaagaagc ugcggggcgg     1560

cgugguguuc guggacgagg ucccgaaggg ccugaccggg aagcucgacg cccggaagau     1620

ccgcgagauc cugaucaagg ccaagaaggg cggcaagauc gccguguaag acuaguuaua     1680

agacugacua gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accgagauua     1740

auaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaauauu cccccccccc cccccccccc cccccccccc ucuagacaau uggaauu        1857


<210>  3
<211>  2023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R2763 coding for the mouse IL-12 protein

<400>  3
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accaugugcc       60

cccagaagcu gaccaucagc ugguucgcca ucgugcuccu ggucuccccg cugauggcca      120

ugugggagcu cgagaaggac guguacgugg ucgaggugga cuggaccccc gacgcgcccg      180

gcgagacggu gaaccugacc ugcgacaccc ccgaggagga cgacaucacc uggacgagcg      240

accagcggca cggggucauc ggcuccggga agacccugac caucaccgug aaggaguucc      300

ucgacgccgg ccaguacacg ugccacaagg gcggcgagac ccugagccac ucccaccugc      360

uccugcacaa gaaggagaac gggaucugga gcaccgagau ccugaagaac uucaagaaca      420

agaccuuccu caagugcgag gccccgaacu acuccgggcg cuucacgugc agcuggcugg      480

ugcagcggaa cauggaccug aaguucaaca ucaaguccag cuccagcucc cccgacagcc      540

gcgccgucac cugcggcaug gccucccuca gcgcggagaa ggugacccug gaccagcggg      600

acuacgagaa guacuccgug agcugccagg aggacgucac cugccccacg gccgaggaga      660

cccugcccau cgagcucgcc cuggaggccc gccagcagaa caaguacgag aacuacucca      720

ccagcuucuu cauccgggac aucaucaagc cggacccccc caagaaccug cagaugaagc      780

cccucaagaa cagccaggug gagguguccu gggaguaccc ggacagcugg uccaccccgc      840

acagcuacuu cucccugaag uucuucgucc gcauccagcg gaagaaggag aagaugaagg      900

agacggagga ggggugcaac cagaagggcg cguuccuggu ggagaagacc agcaccgagg      960

ugcagugcaa gggcgggaac gucugcgugc aggcccagga ccgguacuac aacuccagcu     1020

gcuccaagug ggccugcgug cccugccggg uccgcagcgg caguacuucg ggcaguggua     1080

agccugguag uggugagggu aguacuaagg gucgcgugau ccccgucagc ggcccggccc     1140

ggugccuguc ccagagccgc aaccugcuca agaccacgga cgacauggug aagaccgccc     1200

gggagaagcu gaagcacuac uccugcaccg ccgaggacau cgaccacgag gacaucaccc     1260

gcgaccagac gagcacccug aagaccugcc ucccccugga gcugcacaag aacgaguccu     1320

gccucgccac ccgggagacg agcuccacca cccgcgggag cugccugccg ccccagaaga     1380

ccucccugau gaugacgcuc ugccugggca gcaucuacga ggaccugaag auguaccaga     1440

ccgaguucca ggcgaucaac gccgcccucc agaaccacaa ccaccagcag aucauccugg     1500

acaaggggau gcugguggcc aucgacgagc ucaugcaguc ccugaaccac aacggcgaga     1560

cccugcggca gaagccgccc gucggggagg cggaccccua ccgcgugaag augaagcucu     1620

gcauccugcu gcacgccuuc agcacccggg uggucacgau caaccgcgug augggcuacc     1680

ucuccagcgc cugaggacua gugcaucaca uuuaaaagca ucucagccua ccaugagaau     1740

aagagaaaga aaaugaagau caauagcuua uucaucucuu uuucuuuuuc guugguguaa     1800

agccaacacc cugucuaaaa aacauaaauu ucuuuaauca uuuugccucu uuucucugug     1860

cuucaauuaa uaaaaaaugg aaagaaccua gaucuaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaau gcaucccccc cccccccccc     1980

cccccccccc cccccaaagg cucuuuucag agccaccaga auu                       2023


<210>  4
<211>  2034
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R2244 coding for the Photinus pyralis luciferase protein

<400>  4
gggcgcugcc uacggaggug gcagccaucu ccuucucggc aucaagcuug aggauggagg       60

acgccaagaa caucaagaag ggcccggcgc ccuucuaccc gcuggaggac gggaccgccg      120

gcgagcagcu ccacaaggcc augaagcggu acgcccuggu gccgggcacg aucgccuuca      180

ccgacgccca caucgagguc gacaucaccu acgcggagua cuucgagaug agcgugcgcc      240

uggccgaggc caugaagcgg uacggccuga acaccaacca ccggaucgug gugugcucgg      300

agaacagccu gcaguucuuc augccggugc ugggcgcccu cuucaucggc guggccgucg      360

ccccggcgaa cgacaucuac aacgagcggg agcugcugaa cagcaugggg aucagccagc      420

cgaccguggu guucgugagc aagaagggcc ugcagaagau ccugaacgug cagaagaagc      480

ugcccaucau ccagaagauc aucaucaugg acagcaagac cgacuaccag ggcuuccagu      540

cgauguacac guucgugacc agccaccucc cgccgggcuu caacgaguac gacuucgucc      600

cggagagcuu cgaccgggac aagaccaucg cccugaucau gaacagcagc ggcagcaccg      660

gccugccgaa ggggguggcc cugccgcacc ggaccgccug cgugcgcuuc ucgcacgccc      720

gggaccccau cuucggcaac cagaucaucc cggacaccgc cauccugagc guggugccgu      780

uccaccacgg cuucggcaug uucacgaccc ugggcuaccu caucugcggc uuccgggugg      840

uccugaugua ccgguucgag gaggagcugu uccugcggag ccugcaggac uacaagaucc      900

agagcgcgcu gcucgugccg acccuguuca gcuucuucgc caagagcacc cugaucgaca      960

aguacgaccu gucgaaccug cacgagaucg ccagcggggg cgccccgcug agcaaggagg     1020

ugggcgaggc cguggccaag cgguuccacc ucccgggcau ccgccagggc uacggccuga     1080

ccgagaccac gagcgcgauc cugaucaccc ccgaggggga cgacaagccg ggcgccgugg     1140

gcaagguggu cccguucuuc gaggccaagg ugguggaccu ggacaccggc aagacccugg     1200

gcgugaacca gcggggcgag cugugcgugc gggggccgau gaucaugagc ggcuacguga     1260

acaacccgga ggccaccaac gcccucaucg acaaggacgg cuggcugcac agcggcgaca     1320

ucgccuacug ggacgaggac gagcacuucu ucaucgucga ccggcugaag ucgcugauca     1380

aguacaaggg cuaccaggug gcgccggccg agcuggagag cauccugcuc cagcacccca     1440

acaucuucga cgccggcgug gccgggcugc cggacgacga cgccggcgag cugccggccg     1500

cggugguggu gcuggagcac ggcaagacca ugacggagaa ggagaucguc gacuacgugg     1560

ccagccaggu gaccaccgcc aagaagcugc ggggcggcgu gguguucgug gacgaggucc     1620

cgaagggccu gaccgggaag cucgacgccc ggaagauccg cgagauccug aucaaggcca     1680

agaagggcgg caagaucgcc guguaagacu agugcaucac auuuaaaagc aucucagccu     1740

accaugagaa uaagagaaag aaaaugaaga ucaauagcuu auucaucucu uuuucuuuuu     1800

cguuggugua aagccaacac ccugucuaaa aaacauaaau uucuuuaauc auuuugccuc     1860

uuuucucugu gcuucaauua auaaaaaaug gaaagaaccu agaucuaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ugcauccccc     1980

cccccccccc cccccccccc ccccccaaag gcucuuuuca gagccaccag aauu           2034


<210>  5
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RNA sequence of the non-coding immunostimulatory RNA 

<400>  5
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  6
<211>  1879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R2650/R2651 coding for the influenza nucleoprotein

<400>  6
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauggcca       60

gccagggcac caagcggucc uacgagcaga uggagaccga cggggagcgc cagaacgcca      120

cggagauccg ggcgagcgug ggcaagauga ucgggggcau cgggcgcuuc uacauccaga      180

ugugcaccga gcugaagcuc uccgacuacg agggccggcu gauccagaac agccugacca      240

ucgagcgcau gguccucucc gccuucgacg agcggcgcaa caaguaccug gaggagcacc      300

ccagcgccgg caaggacccg aagaagaccg ggggccccau cuaccggcgc gugaacggga      360

aguggaugcg ggagcugauc cucuacgaca aggaggagau ccgccggauc uggcgccagg      420

ccaacaacgg cgacgacgcc acggcggggc ugacccacau gaugaucugg cacuccaacc      480

ugaacgacgc caccuaccag cggacccgcg cccucgugcg gacgggcaug gacccccgca      540

ugugcagccu gaugcagggc uccacccugc cccggcgcag cggggccgcg ggcgccgccg      600

ucaagggggu gggcaccaug gugauggagc ucguccggau gaucaagcgc ggcaucaacg      660

accggaacuu cuggcggggc gagaacgggc gcaagacccg gaucgccuac gagcgcaugu      720

gcaacauccu gaaggggaag uuccagacgg ccgcgcagaa ggccaugaug gaccaggugc      780

gggagucccg caacccgggc aacgccgagu ucgaggaccu gaccuuccuc gcccggagcg      840

cccugauccu gcgcgggucc guggcgcaca agagcugccu ccccgccugc gucuacggcc      900

ccgccguggc cuccggcuac gacuucgagc gggaggggua cagccuggug ggcaucgacc      960

ccuuccgccu gcuccagaac ucccaggucu acagccugau ccggccgaac gagaaccccg     1020

cccacaaguc ccagcuggug uggauggcgu gccacagcgc cgccuucgag gaccuccgcg     1080

ugcugagcuu caucaagggg accaaggucc ugccccgggg caagcucucc acccgcgggg     1140

ugcagaucgc cagcaacgag aacauggaga cgauggaguc cagcacccug gagcugcggu     1200

cccgcuacug ggccauccgg acccgcagcg gcggcaacac caaccagcag cgggcguccg     1260

ccgggcagau cagcauccag cccacguucu ccgugcagcg caaccucccg uucgaccgga     1320

ccaccaucau ggccgccuuc aacggcaaca ccgaggggcg gacgagcgac augcgcaccg     1380

agaucauccg gaugauggag uccgcgcgcc ccgaggacgu cagcuuccag ggccggggcg     1440

uguucgagcu guccgacgag aaggccgcca gccccaucgu gcccuccuuc gacaugagca     1500

acgagggguc cuacuucuuc ggcgacaacg ccgaggagua cgacaacuga ccacuagugc     1560

aucacauuua aaagcaucuc agccuaccau gagaauaaga gaaagaaaau gaagaucaau     1620

agcuuauuca ucucuuuuuc uuuuucguug guguaaagcc aacacccugu cuaaaaaaca     1680

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag     1740

aaccuagauc uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     1860

uuucagagcc accagaauu                                                  1879


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  7

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stem-loop nucleotide sequence 

<400>  8
caaaggcucu uuucagagcc acca                                              24


<210>  9
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Stem-loop nucleotide sequence 

<400>  9
caaaggcucu uuucagagcc acca                                              24


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  10

Cys Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  11

Cys Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  12

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  13

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10          


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  14

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10              


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  15

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  16

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  17

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  15      






<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  18

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Cys 
    


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  19

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Cys 
        


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  20

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Cys 
            


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  21

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Cys 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  22

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Cys 
            20  


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  23

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Cys 
            20      


<210>  24
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  24

Trp Tyr 
1       


<210>  25
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  25

Tyr Trp 
1       


<210>  26
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  26

Trp Trp 
1       


<210>  27
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  27

Tyr Tyr 
1       


<210>  28
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  28

Trp Tyr Trp 
1           


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  29

Tyr Trp Tyr 
1           


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  30

Trp Trp Trp 
1           


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  31

Tyr Tyr Tyr 
1           


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  32

Trp Tyr Trp Tyr 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  33

Tyr Trp Tyr Trp 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  34

Trp Trp Trp Trp 
1               


<210>  35
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  35

Phe Tyr 
1       


<210>  36
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  36

Tyr Phe 
1       


<210>  37
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  37

Phe Phe 
1       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  38

Phe Tyr Phe 
1           


<210>  39
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  39

Tyr Phe Tyr 
1           


<210>  40
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  40

Phe Phe Phe 
1           


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  41

Phe Tyr Phe Tyr 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  42

Tyr Phe Tyr Phe 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  43

Phe Phe Phe Phe 
1               


<210>  44
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  44

Phe Trp 
1       


<210>  45
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  45

Trp Phe 
1       


<210>  46
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  46

Phe Phe 
1       


<210>  47
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  47

Phe Trp Phe 
1           


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  48

Trp Phe Trp 
1           


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  49

Phe Trp Phe Trp 
1               


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  50

Trp Phe Trp Phe 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  51

Tyr Tyr Tyr Tyr 
1               


<210>  52
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  52

Cys Tyr Cys 
1           


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  53

Cys Trp Cys 
1           


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  54

Cys Trp Tyr Cys 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  55

Cys Tyr Trp Cys 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  56

Cys Trp Trp Cys 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  57

Cys Tyr Tyr Cys 
1               


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  58

Cys Trp Tyr Trp Cys 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  59

Cys Tyr Trp Tyr Cys 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  60

Cys Trp Trp Trp Cys 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  61

Cys Tyr Tyr Tyr Cys 
1               5   


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  62

Cys Trp Tyr Trp Tyr Cys 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  63

Cys Tyr Trp Tyr Trp Cys 
1               5       


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  64

Cys Trp Trp Trp Trp Cys 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  65

Cys Tyr Tyr Tyr Tyr Cys 
1               5       


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  66

Cys Phe Cys 
1           


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  67

Cys Phe Tyr Cys 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  68

Cys Tyr Phe Cys 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  69

Cys Phe Phe Cys 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  70

Cys Tyr Tyr Cys 
1               


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  71

Cys Phe Tyr Phe Cys 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  72

Cys Tyr Phe Tyr Cys 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  73

Cys Phe Phe Phe Cys 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  74

Cys Tyr Tyr Tyr Cys 
1               5   


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  75

Cys Phe Tyr Phe Tyr Cys 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  76

Cys Tyr Phe Tyr Phe Cys 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  77

Cys Phe Phe Phe Phe Cys 
1               5       


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  78

Cys Phe Trp Cys 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  79

Cys Trp Phe Cys 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  80

Cys Phe Phe Cys 
1               


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  81

Cys Phe Trp Phe Cys 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  82

Cys Trp Phe Trp Cys 
1               5   


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  83

Cys Phe Trp Phe Trp Cys 
1               5       


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  84

Cys Trp Phe Trp Phe Cys 
1               5       


<210>  85
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  85

Ser Thr 
1       


<210>  86
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  86

Thr Ser 
1       


<210>  87
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  87

Ser Ser 
1       


<210>  88
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  88

Thr Thr 
1       


<210>  89
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  89

Ser Thr Ser 
1           


<210>  90
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  90

Thr Ser Thr 
1           


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  91

Ser Ser Ser 
1           


<210>  92
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  92

Thr Thr Thr 
1           


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  93

Ser Thr Ser Thr 
1               


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  94

Thr Ser Thr Ser 
1               


<210>  95
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  95

Ser Ser Ser Ser 
1               


<210>  96
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  96

Thr Thr Thr Thr 
1               


<210>  97
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  97

Gln Asn 
1       


<210>  98
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  98

Asn Gln 
1       


<210>  99
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  99

Gln Gln 
1       


<210>  100
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  100

Asn Asn 
1       


<210>  101
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  101

Gln Asn Gln 
1           


<210>  102
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  102

Asn Gln Asn 
1           


<210>  103
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  103

Gln Gln Gln 
1           


<210>  104
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  104

Asn Asn Asn 
1           


<210>  105
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  105

Gln Asn Gln Asn 
1               


<210>  106
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  106

Asn Gln Asn Gln 
1               


<210>  107
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  107

Gln Gln Gln Gln 
1               


<210>  108
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  108

Asn Asn Asn Asn 
1               


<210>  109
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  109

Ser Asn 
1       


<210>  110
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  110

Asn Ser 
1       


<210>  111
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  111

Ser Ser 
1       


<210>  112
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  112

Asn Asn 
1       


<210>  113
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  113

Ser Asn Ser 
1           


<210>  114
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  114

Asn Ser Asn 
1           


<210>  115
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  115

Ser Ser Ser 
1           


<210>  116
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  116

Asn Asn Asn 
1           


<210>  117
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  117

Ser Asn Ser Asn 
1               


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  118

Asn Ser Asn Ser 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  119

Ser Ser Ser Ser 
1               


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  120

Asn Asn Asn Asn 
1               


<210>  121
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  121

Cys Thr Cys 
1           


<210>  122
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  122

Cys Ser Cys 
1           


<210>  123
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  123

Cys Ser Thr Cys 
1               


<210>  124
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  124

Cys Thr Ser Cys 
1               


<210>  125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  125

Cys Ser Ser Cys 
1               


<210>  126
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  126

Cys Thr Thr Cys 
1               


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  127

Cys Ser Thr Ser Cys 
1               5   


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  128

Cys Thr Ser Thr Cys 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  129

Cys Ser Ser Ser Cys 
1               5   


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  130

Cys Thr Thr Thr Cys 
1               5   


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  131

Cys Ser Thr Ser Thr Cys 
1               5       


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  132

Cys Thr Ser Thr Ser Cys 
1               5       


<210>  133
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  133

Cys Ser Ser Ser Ser Cys 
1               5       


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  134

Cys Thr Thr Thr Thr Cys 
1               5       


<210>  135
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  135

Cys Asn Cys 
1           


<210>  136
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  136

Cys Gln Cys 
1           


<210>  137
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  137

Cys Gln Asn Cys 
1               


<210>  138
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  138

Cys Asn Gln Cys 
1               


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  139

Cys Gln Gln Cys 
1               


<210>  140
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  140

Cys Asn Asn Cys 
1               


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  141

Cys Gln Asn Gln Cys 
1               5   


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  142

Cys Asn Gln Asn Cys 
1               5   


<210>  143
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  143

Cys Gln Gln Gln Cys 
1               5   


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  144

Cys Asn Asn Asn Cys 
1               5   


<210>  145
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  145

Cys Gln Asn Gln Asn Cys 
1               5       


<210>  146
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  146

Cys Asn Gln Asn Gln Cys 
1               5       


<210>  147
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  147

Cys Gln Gln Gln Gln Cys 
1               5       


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  148

Cys Asn Asn Asn Asn Cys 
1               5       


<210>  149
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  149

Cys Asn Cys 
1           


<210>  150
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  150

Cys Ser Cys 
1           


<210>  151
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  151

Cys Ser Asn Cys 
1               


<210>  152
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  152

Cys Asn Ser Cys 
1               


<210>  153
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  153

Cys Ser Ser Cys 
1               


<210>  154
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  154

Cys Asn Asn Cys 
1               


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  155

Cys Ser Asn Ser Cys 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  156

Cys Asn Ser Asn Cys 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  157

Cys Ser Ser Ser Cys 
1               5   


<210>  158
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  158

Cys Asn Asn Asn Cys 
1               5   


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  159

Cys Ser Asn Ser Asn Cys 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  160

Cys Asn Ser Asn Ser Cys 
1               5       


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  161

Cys Ser Ser Ser Ser Cys 
1               5       


<210>  162
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  162

Cys Asn Asn Asn Asn Cys 
1               5       


<210>  163
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  163

Leu Val 
1       


<210>  164
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  164

Val Leu 
1       


<210>  165
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  165

Leu Leu 
1       


<210>  166
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  166

Val Val 
1       


<210>  167
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  167

Leu Val Leu 
1           


<210>  168
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  168

Val Leu Val 
1           


<210>  169
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  169

Leu Leu Leu 
1           


<210>  170
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  170

Val Val Val 
1           


<210>  171
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  171

Leu Val Leu Val 
1               


<210>  172
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  172

Val Leu Val Leu 
1               


<210>  173
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  173

Leu Leu Leu Leu 
1               


<210>  174
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  174

Val Val Val Val 
1               


<210>  175
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  175

Ile Ala 
1       


<210>  176
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  176

Ala Ile 
1       


<210>  177
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  177

Ile Ile 
1       


<210>  178
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  178

Ala Ala 
1       


<210>  179
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  179

Ile Ala Ile 
1           


<210>  180
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  180

Ala Ile Ala 
1           


<210>  181
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  181

Ile Ile Ile 
1           


<210>  182
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  182

Ala Ala Ala 
1           


<210>  183
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  183

Ile Ala Ile Ala 
1               


<210>  184
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  184

Ala Ile Ala Ile 
1               


<210>  185
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  185

Ile Ile Ile Ile 
1               


<210>  186
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  186

Ala Ala Ala Ala 
1               


<210>  187
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  187

Met Ala 
1       


<210>  188
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  188

Ala Met 
1       


<210>  189
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  189

Met Met 
1       


<210>  190
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  190

Ala Ala 
1       


<210>  191
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  191

Met Ala Met 
1           


<210>  192
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  192

Ala Met Ala 
1           


<210>  193
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  193

Met Met Met 
1           


<210>  194
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  194

Ala Ala Ala 
1           


<210>  195
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  195

Met Ala Met Ala 
1               


<210>  196
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  196

Ala Met Ala Met 
1               


<210>  197
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  197

Met Met Met Met 
1               


<210>  198
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  198

Cys Val Cys 
1           


<210>  199
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  199

Cys Leu Cys 
1           


<210>  200
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  200

Cys Leu Val Cys 
1               


<210>  201
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  201

Cys Val Leu Cys 
1               


<210>  202
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  202

Cys Leu Leu Cys 
1               


<210>  203
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  203

Cys Val Val Cys 
1               


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  204

Cys Leu Val Leu Cys 
1               5   


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  205

Cys Val Leu Val Cys 
1               5   


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  206

Cys Leu Leu Leu Cys 
1               5   


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  207

Cys Val Val Val Cys 
1               5   


<210>  208
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  208

Cys Leu Val Leu Val Cys 
1               5       


<210>  209
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  209

Cys Val Leu Val Leu Cys 
1               5       


<210>  210
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  210

Cys Leu Leu Leu Leu Cys 
1               5       


<210>  211
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  211

Cys Val Val Val Val Cys 
1               5       


<210>  212
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  212

Cys Ala Cys 
1           


<210>  213
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  213

Cys Ile Cys 
1           


<210>  214
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  214

Cys Ile Ala Cys 
1               


<210>  215
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  215

Cys Ala Ile Cys 
1               


<210>  216
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  216

Cys Ile Ile Cys 
1               


<210>  217
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  217

Cys Ala Ala Cys 
1               


<210>  218
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  218

Cys Ile Ala Ile Cys 
1               5   


<210>  219
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  219

Cys Ala Ile Ala Cys 
1               5   


<210>  220
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  220

Cys Ile Ile Ile Cys 
1               5   


<210>  221
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  221

Cys Ala Ala Ala Cys 
1               5   


<210>  222
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  222

Cys Ile Ala Ile Ala Cys 
1               5       


<210>  223
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  223

Cys Ala Ile Ala Ile Cys 
1               5       


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  224

Cys Ile Ile Ile Ile Cys 
1               5       


<210>  225
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  225

Cys Ala Ala Ala Ala Cys 
1               5       


<210>  226
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  226

Cys Met Cys 
1           


<210>  227
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  227

Cys Met Ala Cys 
1               


<210>  228
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  228

Cys Ala Met Cys 
1               


<210>  229
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  229

Cys Met Met Cys 
1               


<210>  230
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  230

Cys Ala Ala Cys 
1               


<210>  231
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  231

Cys Met Ala Met Cys 
1               5   


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  232

Cys Ala Met Ala Cys 
1               5   


<210>  233
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  233

Cys Met Met Met Cys 
1               5   


<210>  234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  234

Cys Ala Ala Ala Cys 
1               5   


<210>  235
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  235

Cys Met Ala Met Ala Cys 
1               5       


<210>  236
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  236

Cys Ala Met Ala Met Cys 
1               5       


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  237

Cys Met Met Met Met Cys 
1               5       


<210>  238
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  238

Cys Ala Ala Ala Ala Cys 
1               5       


<210>  239
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  239

Asp His 
1       


<210>  240
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  240

His Asp 
1       


<210>  241
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  241

Asp Asp 
1       


<210>  242
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  242

His His 
1       


<210>  243
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  243

Asp His Asp 
1           


<210>  244
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  244

His Asp His 
1           


<210>  245
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  245

Asp Asp Asp 
1           


<210>  246
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  246

His His His 
1           


<210>  247
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  247

Asp His Asp His 
1               


<210>  248
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  248

His Asp His Asp 
1               


<210>  249
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  249

Asp Asp Asp Asp 
1               


<210>  250
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  250

His His His His 
1               


<210>  251
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  251

Cys His Cys 
1           


<210>  252
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  252

Cys Asp Cys 
1           


<210>  253
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  253

Cys Asp His Cys 
1               


<210>  254
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  254

Cys His Asp Cys 
1               


<210>  255
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  255

Cys Asp Asp Cys 
1               


<210>  256
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  256

Cys His His Cys 
1               


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  257

Cys Asp His Asp Cys 
1               5   


<210>  258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  258

Cys His Asp His Cys 
1               5   


<210>  259
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  259

Cys Asp Asp Asp Cys 
1               5   


<210>  260
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  260

Cys His His His Cys 
1               5   


<210>  261
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  261

Cys Asp His Asp His Cys 
1               5       


<210>  262
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  262

Cys His Asp His Asp Cys 
1               5       


<210>  263
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  263

Cys Asp Asp Asp Asp Cys 
1               5       


<210>  264
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  264

Cys His His His His Cys 
1               5       


<210>  265
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  265

Lys Asp Glu Leu 
1               


<210>  266
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  266

Asp Asp Glu Leu 
1               


<210>  267
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  267

Asp Glu Glu Leu 
1               


<210>  268
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  268

Gln Glu Asp Leu 
1               


<210>  269
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  269

Arg Asp Glu Leu 
1               


<210>  270
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  270

Gly Gln Asn Leu Ser Thr Ser Asn 
1               5               


<210>  271
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  271

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  272
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  272

Pro Gln Lys Lys Ile Lys Ser 
1               5           


<210>  273
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  273

Gln Pro Lys Lys Pro 
1               5   


<210>  274
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  274

Arg Lys Lys Arg 
1               


<210>  275
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  275

Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala His Gln 
1               5                   10          


<210>  276
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  276

Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln Arg 
1               5                   10                  15      






<210>  277
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  277

Met Pro Leu Thr Arg Arg Arg Pro Ala Ala Ser Gln Ala Leu Ala Pro 
1               5                   10                  15      


Pro Thr Pro 
            


<210>  278
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  278

Gly Ala Ala Leu Thr Ile Leu Val 
1               5               


<210>  279
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  279

Gly Ala Ala Leu Thr Leu Leu Gly 
1               5               


<210>  280
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  280

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro 
1               5                   10                  15  


<210>  281
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<221>  UNSURE
<222>  7
<223>  cationic component of the polymeric carrier 

<400>  281

Met Leu Phe Asn Leu Arg Xaa Xaa Leu Asn Asn Ala Ala Phe Arg His 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Xaa 
            20                  25                  30          






<210>  282
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  282

Gly Cys Val Cys Ser Ser Asn Pro 
1               5               


<210>  283
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  283

Gly Gln Thr Val Thr Thr Pro Leu 
1               5               


<210>  284
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  284

Gly Gln Glu Leu Ser Gln His Glu 
1               5               


<210>  285
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  285

Gly Asn Ser Pro Ser Tyr Asn Pro 
1               5               


<210>  286
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  286

Gly Val Ser Gly Ser Lys Gly Gln 
1               5               


<210>  287
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  287

Gly Gln Thr Ile Thr Thr Pro Leu 
1               5               


<210>  288
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  288

Gly Gln Thr Leu Thr Thr Pro Leu 
1               5               


<210>  289
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  289

Gly Gln Ile Phe Ser Arg Ser Ala 
1               5               


<210>  290
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  290

Gly Gln Ile His Gly Leu Ser Pro 
1               5               


<210>  291
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  291

Gly Ala Arg Ala Ser Val Leu Ser 
1               5               


<210>  292
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  292

Gly Cys Thr Leu Ser Ala Glu Glu 
1               5               


<210>  293
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  293

Gly Ala Gln Val Ser Ser Gln Lys 
1               5               


<210>  294
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  294

Gly Ala Gln Leu Ser Arg Asn Thr 
1               5               


<210>  295
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  295

Gly Asn Ala Ala Ala Ala Lys Lys 
1               5               


<210>  296
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  296

Gly Asn Glu Ala Ser Tyr Pro Leu 
1               5               


<210>  297
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cationic component of the polymeric carrier 

<400>  297

Gly Ser Ser Lys Ser Lys Pro Lys 
1               5               


<210>  298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  298
gguuuuuuuu uuuuuuuggg                                                   20


<210>  299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  299
ggggguuuuu uuuuuggggg                                                   20


<210>  300
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  300
ggggguuuuu uuuuuuuuuu uuuuuuuuuu uuuuuggggg                             40


<210>  301
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  301
gugugugugu guuuuuuuuu uuuuuuugug ugugugugu                              39


<210>  302
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  302
gguugguugg uuuuuuuuuu uuuuuuuggu ugguugguu                              39


<210>  303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  303
gggggggggu uugggggggg                                                   20


<210>  304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  304
gggggggguu uugggggggg                                                   20


<210>  305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  305
ggggggguuu uuuggggggg                                                   20


<210>  306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  306
ggggggguuu uuuugggggg                                                   20


<210>  307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  307
gggggguuuu uuuugggggg                                                   20


<210>  308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  308
gggggguuuu uuuuuggggg                                                   20


<210>  309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  309
gggggguuuu uuuuuugggg                                                   20


<210>  310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  310
ggggguuuuu uuuuuugggg                                                   20


<210>  311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  311
ggggguuuuu uuuuuuuggg                                                   20


<210>  312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  312
gggguuuuuu uuuuuuuggg                                                   20


<210>  313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  313
gggguuuuuu uuuuuuuugg                                                   20


<210>  314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  314
gguuuuuuuu uuuuuuuugg                                                   20


<210>  315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  315
guuuuuuuuu uuuuuuuuug                                                   20


<210>  316
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  316
gggggggggg uuuggggggg gg                                                22


<210>  317
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  317
gggggggggu uuuggggggg gg                                                22


<210>  318
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  318
gggggggguu uuuugggggg gg                                                22


<210>  319
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  319
gggggggguu uuuuuggggg gg                                                22


<210>  320
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  320
ggggggguuu uuuuuggggg gg                                                22


<210>  321
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  321
ggggggguuu uuuuuugggg gg                                                22


<210>  322
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  322
ggggggguuu uuuuuuuggg gg                                                22


<210>  323
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  323
gggggguuuu uuuuuuuggg gg                                                22


<210>  324
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  324
gggggguuuu uuuuuuuugg gg                                                22


<210>  325
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  325
ggggguuuuu uuuuuuuugg gg                                                22


<210>  326
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  326
ggggguuuuu uuuuuuuuug gg                                                22


<210>  327
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  327
ggguuuuuuu uuuuuuuuug gg                                                22


<210>  328
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  328
gguuuuuuuu uuuuuuuuuu gg                                                22


<210>  329
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  329
gggggggggg guuugggggg gggg                                              24


<210>  330
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  330
gggggggggg uuuugggggg gggg                                              24


<210>  331
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  331
gggggggggu uuuuuggggg gggg                                              24


<210>  332
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  332
gggggggggu uuuuuugggg gggg                                              24


<210>  333
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  333
gggggggguu uuuuuugggg gggg                                              24


<210>  334
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  334
gggggggguu uuuuuuuggg gggg                                              24


<210>  335
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  335
gggggggguu uuuuuuuugg gggg                                              24


<210>  336
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  336
ggggggguuu uuuuuuuugg gggg                                              24


<210>  337
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  337
ggggggguuu uuuuuuuuug gggg                                              24


<210>  338
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  338
gggggguuuu uuuuuuuuug gggg                                              24


<210>  339
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  339
gggggguuuu uuuuuuuuuu gggg                                              24


<210>  340
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  340
gggguuuuuu uuuuuuuuuu gggg                                              24


<210>  341
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  341
ggguuuuuuu uuuuuuuuuu uggg                                              24


<210>  342
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  342
guuuuuuuuu uuuuuuuuuu uuuuuuuuuu ug                                     32


<210>  343
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  343
gguuuuuuuu uuuuuuuuuu uuuuuuuuuu uugg                                   34


<210>  344
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  344
ggguuuuuuu uuuuuuuuuu uuuuuuuuuu uuuggg                                 36


<210>  345
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  345
gggguuuuuu uuuuuuuuuu uuuuuuuuuu uuuuggg                                37


<210>  346
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  346
ggggguuuuu uuuuuuuuuu uuuuuuuuuu uuuuugggg                              39


<210>  347
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  347
gggggguuuu uuuuuuuuuu uuuuuuuuuu uuuuuugggg g                           41


<210>  348
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  348
ggggggguuu uuuuuuuuuu uuuuuuuuuu uuuuuuuggg ggg                         43


<210>  349
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  349
gggggggguu uuuuuuuuuu uuuuuuuuuu uuuuuuuugg ggggg                       45


<210>  350
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  350
gggggggggu uuuuuuuuuu uuuuuuuuuu uuuuuuuuug ggggggg                     47


<210>  351
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  351
gguuugg                                                                  7


<210>  352
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  352
gguuuugg                                                                 8


<210>  353
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  353
gguuuuugg                                                                9


<210>  354
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  354
gguuuuuugg                                                              10


<210>  355
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  355
gguuuuuuug g                                                            11


<210>  356
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  356
gguuuuuuuu gg                                                           12


<210>  357
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  357
gguuuuuuuu ugg                                                          13


<210>  358
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  358
gguuuuuuuu uugg                                                         14


<210>  359
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  359
gguuuuuuuu uuugg                                                        15


<210>  360
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  360
gguuuuuuuu uuuugg                                                       16


<210>  361
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  361
gguuuuuuuu uuuuugg                                                      17


<210>  362
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  362
gguuuuuuuu uuuuuugg                                                     18


<210>  363
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  363
gguuuuuuuu uuuuuuugg                                                    19


<210>  364
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  364
ggguuuggg                                                                9


<210>  365
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  365
ggguuuuggg                                                              10


<210>  366
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  366
ggguuuuugg g                                                            11


<210>  367
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  367
ggguuuuuug gg                                                           12


<210>  368
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  368
ggguuuuuuu ggg                                                          13


<210>  369
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  369
ggguuuuuuu uggg                                                         14


<210>  370
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  370
ggguuuuuuu uuggg                                                        15


<210>  371
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  371
ggguuuuuuu uuuggg                                                       16


<210>  372
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  372
ggguuuuuuu uuuuggg                                                      17


<210>  373
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  373
ggguuuuuuu uuuuuggg                                                     18


<210>  374
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  374
ggguuuuuuu uuuuuuggg                                                    19


<210>  375
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  375
ggguuuuuuu uuuuuuuugg guuuuuuuuu uuuuuugggu uuuuuuuuuu uuuuggg          57


<210>  376
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  376
ggguuuuuuu uuuuuuuugg gggguuuuuu uuuuuuuuug gg                          42


<210>  377
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  377
ggguuugggu uuggguuugg guuuggguuu ggguuugggu uuggguuugg g                51


<210>  378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  378
gguuuuuuuu uuuuuuuggg                                                   20


<210>  379
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  379
cccuuuuuuu uuuuuuuucc cuuuuuuuuu uuuuuucccu uuuuuuuuuu uuuuccc          57


<210>  380
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  380
cccuuucccu uucccuuucc cuuucccuuu cccuuucccu uucccuuucc c                51


<210>  381
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  381
cccuuuuuuu uuuuuuuucc ccccuuuuuu uuuuuuuuuc cc                          42


<210>  382
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  382
uagcgaagcu cuuggaccua gguuuuuuuu uuuuuuuggg ugcguuccua gaaguacacg       60


<210>  383
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  383
uagcgaagcu cuuggaccua gguuuuuuuu uuuuuuuggg ugcguuccua gaaguacacg       60

aucgcuucga gaaccuggau ccaaaaaaaa aaaaaaaccc acgcaaggau cuucaugugc      120


<210>  384
<211>  229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  384
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagauc                  229


<210>  385
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  385
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagaucu cggauuacag      240

cuggaaggag caggaguagu guucuugcuc uaaguaccga gugugcccaa uacccgauca      300

gcuuauuaac gaacggcucc uccucuuaga cugcagcgua agugcggaau cuggggauca      360

aauuacugac ugccuggauu acccucggac auauaaccuu guagcacgcu guugcuguau      420

aggugaccaa cgcccacucg aguagaccag cucucuuagu ccggacaaug auaggaggcg      480

cggucaaucu acuucuggcu aguuaagaau aggcugcacc gaccucuaua aguagcgugu      540

ccucuag                                                                547


<210>  386
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  386
gggagaaagc ucaagcuugg agcaaugccc gcacauugag gaaaccgagu ugcauaucuc       60

agaguauugg cccccgugua gguuauucuu gacagacagu ggagcuuauu cacucccagg      120

auccgagucg cauacuacgg uacuggugac agaccuaggu cgucaguuga ccaguccgcc      180

acuagacgug aguccgucaa agcaguuaga uguuacacuc uauuagaucu cggauuacag      240

cuggaaggag caggaguagu guucuugcuc uaaguaccga gugugcccaa uacccgauca      300

gcuuauuaac gaacggcucc uccucuuaga cugcagcgua agugcggaau cuggggauca      360

aauuacugac ugccuggauu acccucggac auauaaccuu guagcacgcu guugcuguau      420

aggugaccaa cgcccacucg aguagaccag cucucuuagu ccggacaaug auaggaggcg      480

cggucaaucu acuucuggcu aguuaagaau aggcugcacc gaccucuaua aguagcgugu      540

ccucuagagc uacgcagguu cgcaauaaaa gcguugauua gugugcauag aacagaccuc      600

uuauucggug aaacgccaga augcuaaauu ccaauaacuc uucccaaaac gcguacggcc      660

gaagacgcgc gcuuaucuug uguacguucu cgcacaugga agaaucagcg ggcauggugg      720

uagggcaaua ggggagcugg guagcagcga aaaagggccc cugcgcacgu agcuucgcug      780

uucgucugaa acaacccggc auccguugua gcgaucccgu uaucaguguu auucuugugc      840

gcacuaagau ucauggugua gucgacaaua acagcgucuu ggcagauucu ggucacgugc      900

ccuaugcccg ggcuugugcc ucucaggugc acagcgauac uuaaagccuu caagguacuc      960

gacgugggua ccgauucgug acacuuccua agauuauucc acuguguuag ccccgcaccg     1020

ccgaccuaaa cugguccaau guauacgcau ucgcugagcg gaucgauaau aaaagcuuga     1080

auu                                                                   1083


<210>  387
<211>  229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  387
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagauc                  229


<210>  388
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  388
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucua                                                                 546


<210>  389
<211>  856
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  R3971 coding for the mouse Pdcd1(1-157,C83S) protein

<400>  389
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu accauguggg       60

ugcgccaggu ccccuggagc uucaccuggg ccgugcugca gcucuccugg cagagcggcu      120

ggcugcugga ggugccgaac gggcccuggc ggucccucac cuucuacccc gccuggcuga      180

cggucagcga gggcgcgaac gccaccuuca ccugcucccu gagcaacugg uccgaggacc      240

ucaugcugaa cuggaaccgc cugagccccu ccaaccagac cgagaagcag gccgccuuca      300

gcaacgggcu cucccagccg gugcaggacg cccgguucca gaucauccag cugcccaacc      360

gccacgacuu ccacaugaac auccuggaca cgcggcgcaa cgacagcggc aucuaccucu      420

gcggggcgau cucccugcac cccaaggcca agaucgagga gagccccggc gccgagcugg      480

uggucaccga gcggauccuc gagaccucca cccgcuaccc gagcugagga cuagugcauc      540

acauuuaaaa gcaucucagc cuaccaugag aauaagagaa agaaaaugaa gaucaauagc      600

uuauucaucu cuuuuucuuu uucguuggug uaaagccaac acccugucua aaaaacauaa      660

auuucuuuaa ucauuuugcc ucuuuucucu gugcuucaau uaauaaaaaa uggaaagaac      720

cuagaucuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      840

cagagccacc agaauu                                                      856


<210>  390
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AXIN1__Homo sapiens__O15169

<400>  390

Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe 
1               5                   10                  15      


Thr Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu 
            20                  25                  30          


Val Ser Thr Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys 
        35                  40                  45              


Gly Val Gly Ile Lys Gly Glu Thr Ser Thr Ala Thr Pro Arg Arg Ser 
    50                  55                  60                  


Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Thr Pro 
65                  70                  75                  80  


Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln 
                85                  90                  95      


Asp Gly Ile Ser Leu Phe Arg Thr Phe Leu Lys Gln Glu Gly Cys Ala 
            100                 105                 110         


Asp Leu Leu Asp Phe Trp Phe Ala Cys Thr Gly Phe Arg Lys Leu Glu 
        115                 120                 125             


Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile 
    130                 135                 140                 


Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Thr 
145                 150                 155                 160 


Lys Pro Ala Thr Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu 
                165                 170                 175     


Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Thr Glu Ile Gln Ala Thr 
            180                 185                 190         


Met Glu Glu Asn Thr Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu 
        195                 200                 205             


Glu Tyr Thr Arg Thr Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln 
    210                 215                 220                 


Ser Ser Gly Ser Gly Thr Gly Lys Gly Ile Ser Gly Tyr Leu Pro Thr 
225                 230                 235                 240 


Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp 
                245                 250                 255     


Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu 
            260                 265                 270         


Leu Glu Thr Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu 
        275                 280                 285             


Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr 
    290                 295                 300                 


Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Thr Ser Ala Asn Asp 
305                 310                 315                 320 


Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Thr Leu Ser Leu Thr 
                325                 330                 335     


Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His 
            340                 345                 350         


Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu 
        355                 360                 365             


Pro His Ile Pro Arg Thr Tyr Arg Val Pro Lys Glu Val Arg Val Glu 
    370                 375                 380                 


Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln 
385                 390                 395                 400 


Arg Thr Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val 
                405                 410                 415     


Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro 
            420                 425                 430         


Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro 
        435                 440                 445             


Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu 
    450                 455                 460                 


Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg 
465                 470                 475                 480 


Thr Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser 
                485                 490                 495     


Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly 
            500                 505                 510         


His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly 
        515                 520                 525             


Leu His His His Arg His Val His His His Val His His Ser Thr Ala 
    530                 535                 540                 


Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Thr Arg Arg Ala Gln Ser 
545                 550                 555                 560 


Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg 
                565                 570                 575     


Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu 
            580                 585                 590         


Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys 
        595                 600                 605             


Ala Glu Ser Gly Lys Ser Ala Ser Thr Glu Val Pro Gly Ala Ser Glu 
    610                 615                 620                 


Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu 
625                 630                 635                 640 


Lys Glu Ile Ser Arg His Arg Arg Thr Gly His Gly Ser Ser Gly Thr 
                645                 650                 655     


Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His 
            660                 665                 670         


Pro Trp Ala Gly Pro Gln Leu Arg Thr Ser Val Gln Pro Ser His Leu 
        675                 680                 685             


Phe Ile Gln Asp Pro Thr Met Pro Pro His Pro Ala Pro Asn Pro Leu 
    690                 695                 700                 


Thr Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg 
705                 710                 715                 720 


Ala Ser Arg Ala Pro Ser Lys Gln Arg Tyr Val Gln Glu Val Met Arg 
                725                 730                 735     


Arg Gly Arg Ala Cys Val Arg Pro Ala Cys Ala Pro Val Leu His Val 
            740                 745                 750         


Val Pro Ala Val Ser Asp Met Glu Leu Ser Glu Thr Glu Thr Arg Ser 
        755                 760                 765             


Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val 
    770                 775                 780                 


Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr Arg Thr Leu Val 
785                 790                 795                 800 


Arg Gly Arg Ala Val Thr Leu Gly Gln Phe Lys Glu Leu Leu Thr Lys 
                805                 810                 815     


Lys Gly Ser Tyr Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp 
            820                 825                 830         


Cys Gly Val Val Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro 
        835                 840                 845             


Val Phe Glu Glu Lys Ile Ile Gly Lys Val Glu Lys Val Asp 
    850                 855                 860         


<210>  391
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DVL1__Homo sapiens__O14640

<400>  391

Met Ala Glu Thr Lys Ile Ile Tyr His Met Asp Glu Glu Glu Thr Pro 
1               5                   10                  15      


Tyr Leu Val Lys Leu Pro Val Ala Pro Glu Arg Val Thr Leu Ala Asp 
            20                  25                  30          


Phe Lys Asn Val Leu Ser Asn Arg Pro Val His Ala Tyr Lys Phe Phe 
        35                  40                  45              


Phe Lys Ser Met Asp Gln Asp Phe Gly Val Val Lys Glu Glu Ile Phe 
    50                  55                  60                  


Asp Asp Asn Ala Lys Leu Pro Cys Phe Asn Gly Arg Val Val Ser Trp 
65                  70                  75                  80  


Leu Val Leu Ala Glu Gly Ala His Ser Asp Ala Gly Ser Gln Gly Thr 
                85                  90                  95      


Asp Ser His Thr Asp Leu Pro Pro Pro Leu Glu Arg Thr Gly Gly Ile 
            100                 105                 110         


Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ala Ser Ser Arg 
        115                 120                 125             


Asp Gly Met Asp Asn Glu Thr Gly Thr Glu Ser Met Val Ser His Arg 
    130                 135                 140                 


Arg Glu Arg Ala Arg Arg Arg Asn Arg Glu Glu Ala Ala Arg Thr Asn 
145                 150                 155                 160 


Gly His Pro Arg Gly Asp Arg Arg Arg Asp Val Gly Leu Pro Pro Asp 
                165                 170                 175     


Ser Ala Ser Thr Ala Leu Ser Ser Glu Leu Glu Ser Ser Ser Phe Val 
            180                 185                 190         


Asp Ser Asp Glu Asp Gly Ser Thr Ser Arg Leu Ser Ser Ser Thr Glu 
        195                 200                 205             


Gln Ser Thr Ser Ser Arg Leu Ile Arg Lys His Lys Arg Arg Arg Arg 
    210                 215                 220                 


Lys Gln Arg Leu Arg Gln Ala Asp Arg Ala Ser Ser Phe Ser Ser Ile 
225                 230                 235                 240 


Thr Asp Ser Thr Met Ser Leu Asn Ile Val Thr Val Thr Leu Asn Met 
                245                 250                 255     


Glu Arg His His Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Asp 
            260                 265                 270         


Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala 
        275                 280                 285             


Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val 
    290                 295                 300                 


Asn Asp Val Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val 
305                 310                 315                 320 


Leu Arg Glu Ile Val Ser Gln Thr Gly Pro Ile Ser Leu Thr Val Ala 
                325                 330                 335     


Lys Cys Trp Asp Pro Thr Pro Arg Ser Tyr Phe Thr Val Pro Arg Ala 
            340                 345                 350         


Asp Pro Val Arg Pro Ile Asp Pro Ala Ala Trp Leu Ser His Thr Ala 
        355                 360                 365             


Ala Leu Thr Gly Ala Leu Pro Arg Tyr Gly Thr Ser Pro Cys Ser Ser 
    370                 375                 380                 


Ala Val Thr Arg Thr Ser Ser Ser Ser Leu Thr Ser Ser Val Pro Gly 
385                 390                 395                 400 


Ala Pro Gln Leu Glu Glu Ala Pro Leu Thr Val Lys Ser Asp Met Ser 
                405                 410                 415     


Ala Val Val Arg Val Met Gln Leu Pro Asp Ser Gly Leu Glu Ile Arg 
            420                 425                 430         


Asp Arg Met Trp Leu Lys Ile Thr Ile Ala Asn Ala Val Ile Gly Ala 
        435                 440                 445             


Asp Val Val Asp Trp Leu Tyr Thr His Val Glu Gly Phe Lys Glu Arg 
    450                 455                 460                 


Arg Glu Ala Arg Lys Tyr Ala Ser Ser Leu Leu Lys His Gly Phe Leu 
465                 470                 475                 480 


Arg His Thr Val Asn Lys Ile Thr Phe Ser Glu Gln Cys Tyr Tyr Val 
                485                 490                 495     


Phe Gly Asp Leu Cys Ser Asn Leu Ala Thr Leu Asn Leu Asn Ser Gly 
            500                 505                 510         


Ser Ser Gly Thr Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro His Pro 
        515                 520                 525             


Ala Ala Pro Trp Pro Leu Gly Gln Gly Tyr Pro Tyr Gln Tyr Pro Gly 
    530                 535                 540                 


Pro Pro Pro Cys Phe Pro Pro Ala Tyr Gln Asp Pro Gly Phe Ser Tyr 
545                 550                 555                 560 


Gly Ser Gly Ser Thr Gly Ser Gln Gln Ser Glu Gly Ser Lys Ser Ser 
                565                 570                 575     


Gly Ser Thr Arg Ser Ser Arg Arg Ala Pro Gly Arg Glu Lys Glu Arg 
            580                 585                 590         


Arg Ala Ala Gly Ala Gly Gly Ser Gly Ser Glu Ser Asp His Thr Ala 
        595                 600                 605             


Pro Ser Gly Val Gly Ser Ser Trp Arg Glu Arg Pro Ala Gly Gln Leu 
    610                 615                 620                 


Ser Arg Gly Ser Ser Pro Arg Ser Gln Ala Ser Ala Thr Ala Pro Gly 
625                 630                 635                 640 


Leu Pro Pro Pro His Pro Thr Thr Lys Ala Tyr Thr Val Val Gly Gly 
                645                 650                 655     


Pro Pro Gly Gly Pro Pro Val Arg Glu Leu Ala Ala Val Pro Pro Glu 
            660                 665                 670         


Leu Thr Gly Ser Arg Gln Ser Phe Gln Lys Ala Met Gly Asn Pro Cys 
        675                 680                 685             


Glu Phe Phe Val Asp Ile Met 
    690                 695 


<210>  392
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TF7L2__Homo sapiens__Q9NQB0

<400>  392

Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 
1               5                   10                  15      


Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 
            20                  25                  30          


Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 
        35                  40                  45              


Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 
    50                  55                  60                  


Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 
65                  70                  75                  80  


Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 
                85                  90                  95      


Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 
            100                 105                 110         


Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu 
        115                 120                 125             


His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu 
    130                 135                 140                 


His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg 
                165                 170                 175     


Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln 
            180                 185                 190         


His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn 
        195                 200                 205             


Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val 
    210                 215                 220                 


Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser 
225                 230                 235                 240 


Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro 
                245                 250                 255     


Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr 
            260                 265                 270         


Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala 
        275                 280                 285             


Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu 
    290                 295                 300                 


His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys 
305                 310                 315                 320 


Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His 
                325                 330                 335     


Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys 
            340                 345                 350         


Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val 
        355                 360                 365             


Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu 
    370                 375                 380                 


Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr 
385                 390                 395                 400 


Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly 
                405                 410                 415     


Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp 
            420                 425                 430         


Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro 
        435                 440                 445             


Cys Leu Ser Leu Pro Pro Ile Thr Asp Leu Ser Ala Pro Lys Lys Cys 
    450                 455                 460                 


Arg Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys 
465                 470                 475                 480 


Arg Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys 
                485                 490                 495     


Leu Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro 
            500                 505                 510         


Ser Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr 
        515                 520                 525             


Glu Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala 
    530                 535                 540                 


His Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala 
545                 550                 555                 560 


Thr His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro 
                565                 570                 575     


Pro Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro 
            580                 585                 590         


Ser Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro 
        595                 600                 605             


Gln Pro Leu Ser Leu Val Thr Lys Ser Leu Glu 
    610                 615                 


<210>  393
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSK3B__Homo sapiens__P49841

<400>  393

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  394
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA R2025

<400>  394
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  395
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  395
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuagaac gaacugaccu gacgccugaa cuuaugagcg ugcguauuuu uuuuuuuuuu      600

uuuuuuuuuc cucccaacaa augucgauca auagcugggc uguuggagac gcgucagcaa      660

augccguggc uccauaggac guguagacuu cuauuuuuuu uuuuuuuuuu uuuucccggg      720

accacaaaua auauucuugc uugguugggc gcaagggccc cguaucaggu cauaaacggg      780

uacauguugc acaggcuccu uuuuuuuuuu uuuuuuuuuu uucgcugagu uauuccgguc      840

ucaaaagacg gcagacguca gucgacaaca cggucuaaag cagugcuaca aucugccgug      900

uucguguuuu uuuuuuuuuu uuuuuuguga accuacacgg cgugcacugu aguucgcaau      960

ucauagggua ccggcucaga guuaugccuu gguugaaaac ugcccagcau acuuuuuuuu     1020

uuuuuuuuuu uucauauucc caugcuaagc aagggaugcc gcgagucaug uuaagcuuga     1080

auu                                                                   1083


<210>  396
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  396
uagcgaagcu cuuggaccua ccuuuuuuuu uuuuuucccu gcguuccuag aaguacacg        59


<210>  397
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  immune stimmulatory RNA

<400>  397
uagcgaagcu cuuggaccua ccuuuuuuuu uuuuuuuccc ugcguuccua gaaguacacg       60

aucgcuucga gaaccuggau ggaaaaaaaa aaaaaaaggg acgcaaggau cuucaugugc      120


<210>  398
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  1A01_HLA-A/m__Homo_sapiens__P30443

<400>  398

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  399
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  399
auggccguca uggcgccccg aacccuccuc cugcuacucu cgggggcccu ggcccugacc       60

cagaccuggg cgggcuccca cuccaugagg uauuucuuca cauccguguc ccggcccggc      120

cgcggggagc cccgcuucau cgccgugggc uacguggacg acacgcaguu cgugcgguuc      180

gacagcgacg ccgcgagcca gaagauggag ccgcgggcgc cguggauaga gcaggagggg      240

ccggaguauu gggaccagga gacacggaau augaaggccc acucacagac ugaccgagcg      300

aaccugggga cccugcgcgg cuacuacaac cagagcgagg acgguucuca caccauccag      360

auaauguaug gcugcgacgu ggggccggac gggcgcuucc uccgcgggua ccggcaggac      420

gccuacgacg gcaaggauua caucgcccug aacgaggacc ugcgcucuug gaccgcggcg      480

gacauggcag cucagaucac caagcgcaag ugggaggcgg uccaugcggc ggagcagcgg      540

agagucuacc uggagggccg gugcguggac gggcuccgca gauaccugga gaacgggaag      600

gagacgcugc agcgcacgga cccccccaag acacauauga cccaccaccc caucucugac      660

caugaggcca cccugaggug cugggcccug ggcuucuacc cugcggagau cacacugacc      720

uggcagcggg auggggagga ccagacccag gacacggagc ucguggagac caggccugca      780

ggggauggaa ccuuccagaa gugggcggcu gugguggugc cuucuggaga ggagcagaga      840

uacaccugcc augugcagca ugagggucug cccaagcccc ucacccugag augggagcug      900

ucuucccagc ccaccauccc caucgugggc aucauugcug gccugguucu ccuuggagcu      960

gugaucacug gagcuguggu cgcugccgug auguggagga ggaagagcuc agauagaaaa     1020

ggagggaguu acacucaggc ugcaagcagu gacagugccc agggcucuga ugugucucuc     1080

acagcuugua aaguguga                                                   1098


<210>  400
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  400
auggccguga uggcgccccg cacccugcuc cugcugcuca gcggcgcccu ggcccugacc       60

cagacguggg ccggguccca cagcaugcgg uacuucuuca ccuccgucag ccgcccgggc      120

cgcggggagc cccgguucau cgccgugggc uacguggacg acacccaguu cguccgguuc      180

gacuccgacg ccgcgagcca gaagauggag ccccgcgccc ccuggaucga gcaggagggg      240

ccggaguacu gggaccagga gacccggaac augaaggccc acucccagac ggaccgcgcc      300

aaccucggca cccugcgggg cuacuacaac cagagcgagg acggguccca caccauccag      360

aucauguacg gcugcgacgu ggggcccgac ggccgcuucc ugcgggggua ccgccaggac      420

gcguacgacg gcaaggacua caucgcccuc aacgaggacc ugcggagcug gaccgccgcc      480

gacauggccg cgcagaucac gaagcgcaag ugggaggccg ugcacgccgc cgagcagcgg      540

cgcgucuacc uggagggccg gugcguggac gggcuccgcc gguaccugga gaacggcaag      600

gagacccugc agcgcaccga cccgcccaag acccacauga cgcaccaccc caucuccgac      660

cacgaggcca cccuccggug cugggcgcug ggguucuacc ccgccgagau cacccugacc      720

uggcagcgcg acggcgagga ccagacgcag gacaccgagc ucguggagac ccgccccgcc      780

ggcgacggga ccuuccagaa gugggccgcc gucguggugc ccagcggcga ggagcagcgg      840

uacacgugcc acguccagca cgaggggcug ccgaagcccc ugacccuccg cugggagcug      900

uccagccagc ccaccauccc caucgugggc aucaucgcgg ggcuggugcu ccugggcgcc      960

gucaucaccg gcgccguggu ggccgccguc auguggcggc gcaaguccag cgaccggaag     1020

ggcggguccu acacgcaggc ggccagcucc gacagcgccc aggggagcga cgugucccug     1080

accgccugca agguguga                                                   1098


<210>  401
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  401
auggccguca uggccccccg cacccuccuc cuccuccucu ccggcgcccu cgcccucacc       60

cagaccuggg ccggcuccca cuccaugcgc uacuucuuca ccuccgucuc ccgccccggc      120

cgcggcgagc cccgcuucau cgccgucggc uacgucgacg acacccaguu cguccgcuuc      180

gacuccgacg ccgccuccca gaagauggag ccccgcgccc ccuggaucga gcaggagggc      240

cccgaguacu gggaccagga gacccgcaac augaaggccc acucccagac cgaccgcgcc      300

aaccucggca cccuccgcgg cuacuacaac caguccgagg acggcuccca caccauccag      360

aucauguacg gcugcgacgu cggccccgac ggccgcuucc uccgcggcua ccgccaggac      420

gccuacgacg gcaaggacua caucgcccuc aacgaggacc uccgcuccug gaccgccgcc      480

gacauggccg cccagaucac caagcgcaag ugggaggccg uccacgccgc cgagcagcgc      540

cgcgucuacc ucgagggccg cugcgucgac ggccuccgcc gcuaccucga gaacggcaag      600

gagacccucc agcgcaccga cccccccaag acccacauga cccaccaccc caucuccgac      660

cacgaggcca cccuccgcug cugggcccuc ggcuucuacc ccgccgagau cacccucacc      720

uggcagcgcg acggcgagga ccagacccag gacaccgagc ucgucgagac ccgccccgcc      780

ggcgacggca ccuuccagaa gugggccgcc gucgucgucc ccuccggcga ggagcagcgc      840

uacaccugcc acguccagca cgagggccuc cccaagcccc ucacccuccg cugggagcuc      900

uccucccagc ccaccauccc caucgucggc aucaucgccg gccucguccu ccucggcgcc      960

gucaucaccg gcgccgucgu cgccgccguc auguggcgcc gcaaguccuc cgaccgcaag     1020

ggcggcuccu acacccaggc cgccuccucc gacuccgccc agggcuccga cgucucccuc     1080

accgccugca aggucuga                                                   1098


<210>  402
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  402
auggccguga uggcucccag aacccugcuc cuucuguuga gcggcgcauu agcccugaca       60

cagacuuggg cgggguccca cucuaugagg uacuucuuua cgucagucag ucggccugga      120

cgcggugagc cacgauucau cgcuguuggc uauguggacg auacccaauu uguacguuuc      180

gacagcgaug ccgcauccca gaagauggaa ccgagagccc ccuggauuga gcaggaaggg      240

ccugaguacu gggaccagga aacaaggaac augaaagcuc auucucaaac ugaucgggca      300

aaucuaggaa cccuccgcgg cuauuacaac cagucggagg acgguucaca cacaauacag      360

aucauguaug ggugcgaugu gggaccagac ggcagauuuc ugaggggcua ccggcaggau      420

gccuaugacg ggaaggauua cauugcucuu aaugaggacc ugcgcagcug gaccgccgcg      480

gauauggcag cccaaaucac uaaacgaaag ugggaagcug uccaugccgc agagcagaga      540

aggguguacu uggaaggacg guguguugac ggucuccguc gcuaucugga gaacggcaaa      600

gagacacugc agagaaccga ucccccuaag acgcacauga cucaucaccc aauuagugac      660

cacgaagcua cccucaggug cugggccuua ggguucuacc ccgcggagau cacacugacu      720

uggcagcggg acggagaaga ucaaacccag gacacagagc uuguggaaac ccgaccugcc      780

ggcgauggua cguuucagaa gugggcagcu gucgugguac cauccgggga ggagcaacgc      840

uauacuuguc auguucagca cgaaggauug ccgaaacccc ugacacuaag augggagcuc      900

ucuagccagc cuaccauacc aaucgugggc auuaucgccg gccugguccu ucugggggcu      960

gugauuacug gagccguggu cgcagccguu auguggaggc ggaaguccuc agaccgcaaa     1020

gguggcaguu acacacaggc ugcgagcucu gauuccgcac aagggucaga cgugagcuug     1080

accgccugca agguauga                                                   1098


<210>  403
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  403
auggccguga uggcccccag aacccugcug cugcugcuga gcggcgcccu ggcccugacc       60

cagaccuggg ccggcagcca cagcaugaga uacuucuuca ccagcgugag cagacccggc      120

agaggcgagc ccagauucau cgccgugggc uacguggacg acacccaguu cgugagauuc      180

gacagcgacg ccgccagcca gaagauggag cccagagccc ccuggaucga gcaggagggc      240

cccgaguacu gggaccagga gaccagaaac augaaggccc acagccagac cgacagagcc      300

aaccugggca cccugagagg cuacuacaac cagagcgagg acggcagcca caccauccag      360

aucauguacg gcugcgacgu gggccccgac ggcagauucc ugagaggcua cagacaggac      420

gccuacgacg gcaaggacua caucgcccug aacgaggacc ugagaagcug gaccgccgcc      480

gacauggccg cccagaucac caagagaaag ugggaggccg ugcacgccgc cgagcagaga      540

agaguguacc uggagggcag augcguggac ggccugagaa gauaccugga gaacggcaag      600

gagacccugc agagaaccga cccccccaag acccacauga cccaccaccc caucagcgac      660

cacgaggcca cccugagaug cugggcccug ggcuucuacc ccgccgagau cacccugacc      720

uggcagagag acggcgagga ccagacccag gacaccgagc ugguggagac cagacccgcc      780

ggcgacggca ccuuccagaa gugggccgcc gugguggugc ccagcggcga ggagcagaga      840

uacaccugcc acgugcagca cgagggccug cccaagcccc ugacccugag augggagcug      900

agcagccagc ccaccauccc caucgugggc aucaucgccg gccuggugcu gcugggcgcc      960

gugaucaccg gcgccguggu ggccgccgug auguggagaa gaaagagcag cgacagaaag     1020

ggcggcagcu acacccaggc cgccagcagc gacagcgccc agggcagcga cgugagccug     1080

accgccugca agguguga                                                   1098


<210>  404
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       1A01_HLA-A/m__Homo_sapiens__AAA59652

<400>  404
auggccguga uggcucccag aacccugcuc cugcuucuga gcggcgcccu cgcgcugaca       60

cagacguggg cuggguccca cucuaugcgg uacuucuuua ccagcgucuc ccgcccugga      120

agaggcgagc cgcgguucau cgccguuggg uauguggacg auacacaauu ugugcgcuuc      180

gacucugaug ccgcuagcca gaagauggaa cccagagccc cuuggauuga gcaggaagga      240

cccgaguacu gggaccagga aacccggaac augaaagcuc auucccaaac agaucgcgcc      300

aaucuuggca cccugagagg guauuacaac cagucugagg acggaagcca cacaauccag      360

auuauguaug gcugcgaugu cggcccugac gggcgguuuc uccgcggaua cagacaggau      420

gcguaugacg gcaaggauua caucgcccug aaugaggacc ugcgguccug gaccgcugcc      480

gauauggcug cccaaauuac gaaacgcaag ugggaagcgg ugcaugccgc ugagcagaga      540

cggguuuacc ucgaagggcg cuguguggac ggacugagac gguaucuuga gaacggcaaa      600

gagacccugc agagaacaga ucccccuaag acccacauga cacaucaccc gaucagcgac      660

cacgaagcca cccuccgcug cugggcucug ggguucuacc ccgccgagau cacgcuuaca      720

uggcagcggg acggagaaga ucaaacccag gacacagagc uggucgaaac cagaccugcc      780

ggcgauggca ccuuucagaa gugggcugcg gugguugugc ccucugggga ggagcaacgc      840

uauacauguc auguccagca cgaaggacuc ccuaaacccc ugacgcugcg gugggagcuc      900

uccagccagc cgaccauucc uaucgugggc auuaucgccg ggcuggugcu ucugggagcu      960

gucauuacag gcgccguugu ggccgcugug auguggagac gcaagucuuc cgaccggaaa     1020

gggggaagcu acacccaggc cgcgucuucc gauagcgcuc aaggcuccga cgucucucuc     1080

acagccugca agguguga                                                   1098


<210>  405
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  1A02__Homo_sapiens__P01892

<400>  405

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  406
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  1A02__Homo_sapiens__AAA59606

<400>  406
auggccguca uggcgccccg aacccucguc cugcuacucu cgggggcucu ggcccugacc       60

cagaccuggg cgggcucuca cuccaugagg uauuucuuca cauccguguc ccggcccggc      120

cgcggggagc cccgcuucau cgcagugggc uacguggacg acacgcaguu cgugcgguuc      180

gacagcgacg ccgcgagcca gaggauggag ccgcgggcgc cguggauaga gcaggagggu      240

ccggaguauu gggacgggga gacacggaaa gugaaggccc acucacagac ucaccgagug      300

gaccugggga cccugcgcgg cuacuacaac cagagcgagg ccgguucuca caccguccag      360

aggauguaug gcugcgacgu ggggucggac uggcgcuucc uccgcgggua ccaccaguac      420

gccuacgacg gcaaggauua caucgcccug aaagaggacc ugcgcucuug gaccgcggcg      480

gacauggcag cucagaccac caagcacaag ugggaggcgg cccauguggc ggagcaguug      540

agagccuacc uggagggcac gugcguggag uggcuccgca gauaccugga gaacgggaag      600

gagacgcugc agcgcacgga cgcccccaaa acgcauauga cucaccacgc ugucucugac      660

caugaagcca cccugaggug cugggcccug agcuucuacc cugcggagau cacacugacc      720

uggcagcggg auggggagga ccagacccag gacacggagc ucguggagac caggccugca      780

ggggauggaa ccuuccagaa gugggcggcu gugguggugc cuucuggaca ggagcagaga      840

uacaccugcc augugcagca ugaggguuug cccaagcccc ucacccugag augggagccg      900

ucuucccagc ccaccauccc caucgugggc aucauugcug gccugguucu cuuuggagcu      960

gugaucacug gagcuguggu cgcugcugug auguggagga ggaagagcuc agauagaaaa     1020

ggagggagcu acucucaggc ugcaagcagu gacagugccc agggcucuga ugugucucuc     1080

acagcuugua aaguguga                                                   1098


<210>  407
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       1A02__Homo_sapiens__AAA59606

<400>  407
auggccguga uggcgccccg cacccugguc cuccugcuga gcggcgcccu cgcccugacc       60

cagacguggg ccggguccca cagcaugcgg uacuucuuca ccuccgugag ccgcccgggc      120

cggggcgagc cccgcuucau cgccgugggc uacgucgacg acacccaguu cgugcgguuc      180

gacuccgacg ccgcgagcca gcgcauggag ccccgggccc ccuggaucga gcaggagggg      240

ccggaguacu gggacggcga gacccgcaag gugaaggccc acucccagac gcaccggguc      300

gaccugggca cccuccgcgg guacuacaac cagagcgagg ccggcuccca caccgugcag      360

cggauguacg ggugcgacgu gggcagcgac uggcgcuucc ugcgggggua ccaccaguac      420

gcguacgacg gcaaggacua caucgcccug aaggaggacc uccgcuccug gaccgccgcc      480

gacauggccg cgcagacgac caagcacaag ugggaggccg cccacgucgc cgagcagcug      540

cgggccuacc uggaggggac cugcguggag uggcuccgcc gguaccugga gaacgggaag      600

gagacccugc agcgcacgga cgcgcccaag acccacauga cccaccacgc cgugagcgac      660

cacgaggcca cccuccggug cugggcccug uccuucuacc ccgccgagau cacgcugacc      720

uggcagcgcg acggcgagga ccagacccag gacaccgagc ucgucgagac gcggcccgcg      780

ggggacggca ccuuccagaa gugggccgcc gugguggucc cgagcggcca ggagcagcgc      840

uacacgugcc acgugcagca cgaggggcug cccaagcccc ugacccuccg cugggagccc      900

uccagccagc cgaccauccc caucgugggc aucaucgccg ggcugguccu guucggcgcc      960

gugaucaccg gggcgguggu cgccgccgug auguggcggc gcaaguccag cgaccggaag     1020

ggcggcuccu acagccaggc cgcgagcucc gacagcgccc agggguccga cgugagccuc     1080

accgccugca aggucuga                                                   1098


<210>  408
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       1A02__Homo_sapiens__AAA59606

<400>  408
auggccguca uggccccccg cacccucguc cuccuccucu ccggcgcccu cgcccucacc       60

cagaccuggg ccggcuccca cuccaugcgc uacuucuuca ccuccgucuc ccgccccggc      120

cgcggcgagc cccgcuucau cgccgucggc uacgucgacg acacccaguu cguccgcuuc      180

gacuccgacg ccgccuccca gcgcauggag ccccgcgccc ccuggaucga gcaggagggc      240

cccgaguacu gggacggcga gacccgcaag gucaaggccc acucccagac ccaccgcguc      300

gaccucggca cccuccgcgg cuacuacaac caguccgagg ccggcuccca caccguccag      360

cgcauguacg gcugcgacgu cggcuccgac uggcgcuucc uccgcggcua ccaccaguac      420

gccuacgacg gcaaggacua caucgcccuc aaggaggacc uccgcuccug gaccgccgcc      480

gacauggccg cccagaccac caagcacaag ugggaggccg cccacgucgc cgagcagcuc      540

cgcgccuacc ucgagggcac cugcgucgag uggcuccgcc gcuaccucga gaacggcaag      600

gagacccucc agcgcaccga cgcccccaag acccacauga cccaccacgc cgucuccgac      660

cacgaggcca cccuccgcug cugggcccuc uccuucuacc ccgccgagau cacccucacc      720

uggcagcgcg acggcgagga ccagacccag gacaccgagc ucgucgagac ccgccccgcc      780

ggcgacggca ccuuccagaa gugggccgcc gucgucgucc ccuccggcca ggagcagcgc      840

uacaccugcc acguccagca cgagggccuc cccaagcccc ucacccuccg cugggagccc      900

uccucccagc ccaccauccc caucgucggc aucaucgccg gccucguccu cuucggcgcc      960

gucaucaccg gcgccgucgu cgccgccguc auguggcgcc gcaaguccuc cgaccgcaag     1020

ggcggcuccu acucccaggc cgccuccucc gacuccgccc agggcuccga cgucucccuc     1080

accgccugca aggucuga                                                   1098


<210>  409
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       1A02__Homo_sapiens__AAA59606

<400>  409
auggccguga uggcucccag aacccugguc cuccuucuga gcggcgcauu ggccuuaaca       60

cagacuuggg cgggguccca cucuaugagg uacuucuuua cgucaguuag ucggccugga      120

cgcggugagc cacgauucau cgcugugggc uauguagacg auacccaauu ugugcguuuc      180

gacagcgaug ccgcauccca gagaauggaa ccgagggccc ccuggauuga gcaggaaggg      240

ccugaguacu gggacggaga aacacggaag gucaaagcuc auucucagac ucaccgcgug      300

gaucugggca cccuaagagg uuauuacaac caaucggagg cagggucaca uacaguucag      360

aggauguaug gaugcgacgu gggcagcgau uggcgguuuc uccgcggcua ccaccaguau      420

gccuacgacg ggaaggauua cauagcucug aaagaggacc uucgaaguug gaccgccgcg      480

gauauggcag cccagacuac aaagcauaaa ugggaagcug cccacgucgc agagcaacug      540

agagcuuauu uggaaggaac cuguguggag uggcucaggc gguaccugga gaaugguaag      600

gaaacgcugc agcguacuga cgccccaaag acccacauga cacaucacgc gguauccgau      660

caugaggcca cucuccgcug cugggcauua ucuuucuauc ccgcugaaau cacccugaca      720

uggcagagag acggcgagga ccagacccaa gauacggaac uuguugagac uaggccugcc      780

ggggacggaa cauuucagaa augggcugcc guggucgugc caagcggcca ggagcaacgg      840

uacaccuguc acgugcagca cgaagguuug cccaagccuc ugacucuacg augggagcca      900

uccucacagc cgacaauucc caucgucggg auuaucgcag gacucguucu guucggcgcc      960

gugauaaccg gcgcuguagu ggcggcaguc auguggcgca gaaaaaguag cgauaggaaa     1020

gggggaucuu auucccaggc cgcuucaagc gacagugccc aagguucuga ugugucccuu     1080

acggcaugca agguuuga                                                   1098


<210>  410
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       1A02__Homo_sapiens__AAA59606

<400>  410
auggccguga uggcccccag aacccuggug cugcugcuga gcggcgcccu ggcccugacc       60

cagaccuggg ccggcagcca cagcaugaga uacuucuuca ccagcgugag cagacccggc      120

agaggcgagc ccagauucau cgccgugggc uacguggacg acacccaguu cgugagauuc      180

gacagcgacg ccgccagcca gagaauggag cccagagccc ccuggaucga gcaggagggc      240

cccgaguacu gggacggcga gaccagaaag gugaaggccc acagccagac ccacagagug      300

gaccugggca cccugagagg cuacuacaac cagagcgagg ccggcagcca caccgugcag      360

agaauguacg gcugcgacgu gggcagcgac uggagauucc ugagaggcua ccaccaguac      420

gccuacgacg gcaaggacua caucgcccug aaggaggacc ugagaagcug gaccgccgcc      480

gacauggccg cccagaccac caagcacaag ugggaggccg cccacguggc cgagcagcug      540

agagccuacc uggagggcac cugcguggag uggcugagaa gauaccugga gaacggcaag      600

gagacccugc agagaaccga cgcccccaag acccacauga cccaccacgc cgugagcgac      660

cacgaggcca cccugagaug cugggcccug agcuucuacc ccgccgagau cacccugacc      720

uggcagagag acggcgagga ccagacccag gacaccgagc ugguggagac cagacccgcc      780

ggcgacggca ccuuccagaa gugggccgcc gugguggugc ccagcggcca ggagcagaga      840

uacaccugcc acgugcagca cgagggccug cccaagcccc ugacccugag augggagccc      900

agcagccagc ccaccauccc caucgugggc aucaucgccg gccuggugcu guucggcgcc      960

gugaucaccg gcgccguggu ggccgccgug auguggagaa gaaagagcag cgacagaaag     1020

ggcggcagcu acagccaggc cgccagcagc gacagcgccc agggcagcga cgugagccug     1080

accgccugca agguguga                                                   1098


<210>  411
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       1A02__Homo_sapiens__AAA59606

<400>  411
auggccguga uggcucccag aacccugguc cuccugcuua gcggcgcccu ggcgcucaca       60

cagacguggg cuggguccca cucuaugcgg uacuucuuua ccagcguuuc ccgcccugga      120

agaggcgagc cgcgguucau cgccgugggg uauguggacg auacacaauu uguccgcuuc      180

gacucugaug ccgcuagcca gagaauggaa ccccgggccc cuuggauuga gcaggaagga      240

cccgaguacu gggacggcga aacccgcaag gugaaagcuc auucccagac acacagaguu      300

gaucugggga cccuucgggg auauuacaac caaucugagg ccggcagcca uacagugcag      360

cgcauguaug gcugcgacgu cggguccgau uggagauuuc ugcggggaua ccaccaguau      420

gcguacgacg gcaaggauua caucgcccuc aaagaggacc ugcgcagcug gaccgcugcc      480

gauauggcug cccagacgac caagcauaaa ugggaagcgg cccacguggc ugagcaacug      540

agagccuauc ucgaagggac auguguugag uggcugcggc gcuaccuuga gaauggaaag      600

gaaacccugc agagaacaga cgcuccuaag acccacauga cgcaucacgc cgugucugau      660

caugaggcca cacuccggug cugggcucug uccuucuauc ccgcggaaau uacccuuaca      720

uggcagagag acggcgagga ccagacccaa gauaccgaac uggucgagac acgcccugcc      780

ggggacggaa cguuucagaa augggcugcc gugguggucc cgagcggcca ggagcaacgg      840

uacaccuguc acguucagca cgaaggccuc cccaagccuc ugacacugag augggagccc      900

ucuucccagc cuaccauccc cauugugggg aucaucgccg gacucgugcu guucggcgcu      960

gucauuacag gggccguggu ugcggcugug auguggcgcc ggaaaagcuc ugauagaaag     1020

ggaggcuccu auagccaggc cgccuccucu gacagcgcuc aaggguccga ugucagccuu     1080

accgccugca aaguguga                                                   1098


<210>  412
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  5T4__Homo_sapiens__Q13641

<400>  412

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  413
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5T4__Homo_sapiens__AAH37161

<400>  413
augccugggg ggugcucccg gggccccgcc gccggggacg ggcgucugcg gcuggcgcga       60

cuagcgcugg uacuccuggg cugggucucc ucgucuucuc ccaccuccuc ggcauccucc      120

uucuccuccu cggcgccguu ccuggcuucc gccguguccg cccagccccc gcugccggac      180

cagugccccg cgcugugcga gugcuccgag gcagcgcgca cagucaagug cguuaaccgc      240

aaucugaccg aggugcccac ggaccugccc gccuacgugc gcaaccucuu ccuuaccggc      300

aaccagcugg ccgugcuccc ugccggcgcc uucgcccgcc ggccgccgcu ggcggagcug      360

gccgcgcuca accucagcgg cagccgccug gacgaggugc gcgcgggcgc cuucgagcau      420

cugcccagcc ugcgccagcu cgaccucagc cacaacccac uggccgaccu cagucccuuc      480

gcuuucucgg gcagcaaugc cagcgucucg gcccccaguc cccuugugga acugauccug      540

aaccacaucg ugcccccuga agaugagcgg cagaaccgga gcuucgaggg caugguggug      600

gcggcccugc uggcgggccg ugcacugcag gggcuccgcc gcuuggagcu ggccagcaac      660

cacuuccuuu accugccgcg ggaugugcug gcccaacugc ccagccucag gcaccuggac      720

uuaaguaaua auucgcuggu gagccugacc uacguguccu uccgcaaccu gacacaucua      780

gaaagccucc accuggagga caaugcccuc aagguccuuc acaauggcac ccuggcugag      840

uugcaagguc uaccccacau uaggguuuuc cuggacaaca aucccugggu cugcgacugc      900

cacauggcag acauggugac cuggcucaag gaaacagagg uagugcaggg caaagaccgg      960

cucaccugug cauauccgga aaaaaugagg aaucgggucc ucuuggaacu caacagugcu     1020

gaccuggacu gugacccgau ucuuccccca ucccugcaaa ccucuuaugu cuuccugggu     1080

auuguuuuag cccugauagg cgcuauuuuc cuccugguuu uguauuugaa ccgcaagggg     1140

auaaaaaagu ggaugcauaa caucagagau gccugcaggg aucacaugga aggguaucau     1200

uacagauaug aaaucaaugc ggaccccaga uuaacgaacc ucaguucuaa cucggauguc     1260

uga                                                                   1263


<210>  414
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       5T4__Homo_sapiens__AAH37161

<400>  414
augcccggcg ggugcagccg cggccccgcc gccggggacg gccggcugcg ccucgcgcgg       60

cuggcccugg ugcuccuggg gugggucucc agcuccagcc ccaccuccag cgccuccagc      120

uucuccagcu ccgcccccuu ccuggccagc gcgguguccg cccagccccc gcuccccgac      180

cagugccccg cccugugcga gugcagcgag gccgcgcgca ccgugaagug cgucaaccgg      240

aaccugacgg aggugcccac cgaccucccg gccuacgugc gcaaccuguu ccugaccggc      300

aaccagcucg ccguccugcc cgccggcgcc uucgcgcggc gcccgccccu ggccgagcuc      360

gccgcccuga accuguccgg gagccggcuc gacgaggugc gcgccggcgc guucgagcac      420

cuccccuccc ugcggcagcu ggaccugagc cacaaccccc uggccgaccu cucccccuuc      480

gccuucagcg ggagcaacgc cuccgugagc gcccccuccc cgcuggucga gcugauccuc      540

aaccacaucg ugccgcccga ggacgagcgc cagaaccgga gcuucgaggg cauggugguc      600

gcggcccugc uggccgggcg cgcccuccag ggccugcggc gccuggagcu cgccuccaac      660

cacuuccugu accugccccg ggacgugcuc gcgcagcugc ccagccugcg ccaccucgac      720

cuguccaaca acagccuggu gucccucacc uacgucagcu uccggaaccu gacgcaccug      780

gagucccucc accuggagga caacgcccug aaggugcucc acaacggcac ccuggccgag      840

cugcaggggc ugccccacau ccgcguguuc cucgacaaca accccugggu cugcgacugc      900

cacauggccg acauggugac cuggcugaag gagaccgagg ugguccaggg caaggaccgg      960

cugacgugcg cguaccccga gaagaugcgc aaccgcgugc uccuggagcu gaacagcgcc     1020

gaccucgacu gcgacccgau ccugccgccc ucccugcaga ccagcuacgu guuccucggg     1080

aucguccugg cccugaucgg cgccaucuuc cuccuggugc uguaccucaa ccggaagggc     1140

aucaagaagu ggaugcacaa cauccgcgac gccugccggg accacaugga gggguaccac     1200

uaccgcuacg agaucaacgc ggacccccgg cugaccaacc uguccagcaa cuccgacguc     1260

uga                                                                   1263


<210>  415
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       5T4__Homo_sapiens__AAH37161

<400>  415
augcccggcg gcugcucccg cggccccgcc gccggcgacg gccgccuccg ccucgcccgc       60

cucgcccucg uccuccucgg cugggucucc uccuccuccc ccaccuccuc cgccuccucc      120

uucuccuccu ccgcccccuu ccucgccucc gccgucuccg cccagccccc ccuccccgac      180

cagugccccg cccucugcga gugcuccgag gccgcccgca ccgucaagug cgucaaccgc      240

aaccucaccg agguccccac cgaccucccc gccuacgucc gcaaccucuu ccucaccggc      300

aaccagcucg ccguccuccc cgccggcgcc uucgcccgcc gccccccccu cgccgagcuc      360

gccgcccuca accucuccgg cucccgccuc gacgaggucc gcgccggcgc cuucgagcac      420

cuccccuccc uccgccagcu cgaccucucc cacaaccccc ucgccgaccu cucccccuuc      480

gccuucuccg gcuccaacgc cuccgucucc gcccccuccc cccucgucga gcucauccuc      540

aaccacaucg ucccccccga ggacgagcgc cagaaccgcu ccuucgaggg cauggucguc      600

gccgcccucc ucgccggccg cgcccuccag ggccuccgcc gccucgagcu cgccuccaac      660

cacuuccucu accucccccg cgacguccuc gcccagcucc ccucccuccg ccaccucgac      720

cucuccaaca acucccucgu cucccucacc uacgucuccu uccgcaaccu cacccaccuc      780

gagucccucc accucgagga caacgcccuc aagguccucc acaacggcac ccucgccgag      840

cuccagggcc ucccccacau ccgcgucuuc cucgacaaca accccugggu cugcgacugc      900

cacauggccg acauggucac cuggcucaag gagaccgagg ucguccaggg caaggaccgc      960

cucaccugcg ccuaccccga gaagaugcgc aaccgcgucc uccucgagcu caacuccgcc     1020

gaccucgacu gcgaccccau ccuccccccc ucccuccaga ccuccuacgu cuuccucggc     1080

aucguccucg cccucaucgg cgccaucuuc cuccucgucc ucuaccucaa ccgcaagggc     1140

aucaagaagu ggaugcacaa cauccgcgac gccugccgcg accacaugga gggcuaccac     1200

uaccgcuacg agaucaacgc cgacccccgc cucaccaacc ucuccuccaa cuccgacguc     1260

uga                                                                   1263


<210>  416
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       5T4__Homo_sapiens__AAH37161

<400>  416
augcccggcg ggugcagcag aggaccugcc gcuggugacg gcaggcugcg gcucgcacgc       60

cuugcccugg uguuguuagg gugggucucc ucuucaaguc caaccagcuc cgcgucuucg      120

uucucaagca gugcuccguu ucuggccucc gcaguuucug cccagccccc ucuaccagau      180

caaugucccg cucucugcga guguagcgaa gcagcccgaa cagugaagug cguaaaccgu      240

aaucugacug aggugccuac ggaccuucca gcuuacguca gaaaccuguu cuugaccgga      300

aaucagcucg ccgugcugcc cgcgggcgca uuugccaggc ggccuccacu ggcugaacuc      360

gccgcauuaa accuguccgg uucacgccuu gaugagguua gagcuggggc cuucgaacac      420

uugccgaguc ugaggcagcu agaccucagc cauaaucccc uggcggaucu uucuccuuuu      480

gccuucuccg gaucaaacgc aagcgugagu gcuccaucuc cccuggucga guugauccuc      540

aaucacauug ugccuccaga ggacgaacgg cagaaccgcu ccuuugaggg caugguaguu      600

gccgcucugu uagccggccg agcacugcaa gggcucagaa ggcuugaacu ggccagcaau      660

cauuucuugu aucuaccccg ggaugugcug gcucagcucc cgucgcugcg ucaccuugac      720

cugucuaaca auuccuuggu cucacucaca uacgugaguu uucgcaaccu gacucauuua      780

gagagccugc accuagagga uaaugcgcuc aaagugcugc acaacggaac ccuugcagaa      840

uugcaggguc ugccucauau aagagucuuc cucgacaaua accccugggu uugugauugc      900

cacauggccg acauggugac auggcugaag gagaccgaag uagugcaggg caaagauagg      960

cuuacuugug cuuauccaga gaagaugcgg aaccgagucc uguuggaacu caauuccgcc     1020

gaccuggacu gcgauccuau cuuaccccca ucucugcaaa caagcuacgu guuucuaggg     1080

auuguucucg cacugaucgg agccauuuuc cuuuuggugc uguaucucaa ccgcaaaggc     1140

aucaagaagu ggaugcauaa uauaagagac gcuuguaggg aucacaugga ggguuaccac     1200

uaucgguacg agaucaacgc cgacccccgc cugaccaauu uaucaaguaa cuccgauguc     1260

uga                                                                   1263


<210>  417
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       5T4__Homo_sapiens__AAH37161

<400>  417
augcccggcg gcugcagcag aggccccgcc gccggcgacg gcagacugag acuggccaga       60

cuggcccugg ugcugcuggg cugggugagc agcagcagcc ccaccagcag cgccagcagc      120

uucagcagca gcgcccccuu ccuggccagc gccgugagcg cccagccccc ccugcccgac      180

cagugccccg cccugugcga gugcagcgag gccgccagaa ccgugaagug cgugaacaga      240

aaccugaccg aggugcccac cgaccugccc gccuacguga gaaaccuguu ccugaccggc      300

aaccagcugg ccgugcugcc cgccggcgcc uucgccagaa gacccccccu ggccgagcug      360

gccgcccuga accugagcgg cagcagacug gacgagguga gagccggcgc cuucgagcac      420

cugcccagcc ugagacagcu ggaccugagc cacaaccccc uggccgaccu gagccccuuc      480

gccuucagcg gcagcaacgc cagcgugagc gcccccagcc cccuggugga gcugauccug      540

aaccacaucg ugccccccga ggacgagaga cagaacagaa gcuucgaggg caugguggug      600

gccgcccugc uggccggcag agcccugcag ggccugagaa gacuggagcu ggccagcaac      660

cacuuccugu accugcccag agacgugcug gcccagcugc ccagccugag acaccuggac      720

cugagcaaca acagccuggu gagccugacc uacgugagcu ucagaaaccu gacccaccug      780

gagagccugc accuggagga caacgcccug aaggugcugc acaacggcac ccuggccgag      840

cugcagggcc ugccccacau cagaguguuc cuggacaaca accccugggu gugcgacugc      900

cacauggccg acauggugac cuggcugaag gagaccgagg uggugcaggg caaggacaga      960

cugaccugcg ccuaccccga gaagaugaga aacagagugc ugcuggagcu gaacagcgcc     1020

gaccuggacu gcgaccccau ccugcccccc agccugcaga ccagcuacgu guuccugggc     1080

aucgugcugg cccugaucgg cgccaucuuc cugcuggugc uguaccugaa cagaaagggc     1140

aucaagaagu ggaugcacaa caucagagac gccugcagag accacaugga gggcuaccac     1200

uacagauacg agaucaacgc cgaccccaga cugaccaacc ugagcagcaa cagcgacgug     1260

uga                                                                   1263


<210>  418
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       5T4__Homo_sapiens__AAH37161

<400>  418
augcccggcg ggugcagcag aggaccugcc gcuggcgacg ggcggcugcg ccucgccaga       60

cuggcgcuug ugcugcucgg augggucucc ucuagcuccc cgaccucuag cgcuuccucu      120

uucagcucca gcgcccccuu ucuggccucu gcuguuuccg cccagccucc ccuuccugau      180

caaugucccg cucugugcga guguagcgaa gccgcgcgga cagugaagug cgugaaccgc      240

aaucucacgg aggucccuac cgaccugccg gccuacguga gaaaccuguu ccucacaggc      300

aaucagcugg cuguucuucc cgccggggcu uuugcccggc gcccuccccu ggcggaacuc      360

gccgcucuga accuuucugg auccagacug gaugaggugc gggccggcgc uuucgaacac      420

cucccuagcc ugcgccagcu ggaccucucu cauaaucccc uggccgaucu uuccccguuu      480

gccuucagcg gcuccaacgc uucugucagc gcgccuagcc cccuggugga gcucauccug      540

aaucacauug uuccucccga ggacgaaaga cagaaccggu ccuuugaggg gauggugguc      600

gccgcccuuc uggcuggacg cgcccuccaa ggccugagac ggcuggaacu cgcuucuaau      660

cauuuccugu aucuuccccg cgaugugcug gcccagcucc cuucccugag acaccuugac      720

cugagcaaca auucucucgu gagccugacc uacgucuccu uucggaaccu gacacaucuc      780

gagucucugc accuugagga uaaugcgcug aaaguucucc acaacgggac ccuggcugaa      840

cugcagggac uuccgcauau cagaguguuc cucgacaaua accccugggu gugugauugc      900

cacauggccg acauggucac auggcugaag gagaccgaag ugguucaggg caaagaucgc      960

cugacgugug ccuauccuga gaagaugcgg aacagagugc uccuggaacu uaauagcgcu     1020

gaccuggacu gcgaucccau ucucccuccc ucccugcaaa ccagcuacgu cuuucugggg     1080

aucgugcuug cccucauugg agcuaucuuc cugcugguuc ucuaucugaa ccgcaaaggc     1140

aucaagaagu ggaugcauaa uauucgggac gccuguagag aucacaugga gggcuaccac     1200

uaucgcuacg agaucaacgc ggacccgcgg cuuacaaauc ugucuuccaa cagcgaugug     1260

uga                                                                   1263


<210>  419
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ACRBP__Homo_sapiens__Q8NEB7

<400>  419

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Val Thr 
145                 150                 155                 160 


Glu Arg Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 175     


Glu Glu Leu Leu Gln Ser Ser Leu Ser Leu Gly Gly Gln Glu Gln Ala 
            180                 185                 190         


Pro Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr 
        195                 200                 205             


Gln Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu 
    210                 215                 220                 


Glu Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu 
225                 230                 235                 240 


Gly Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe 
                245                 250                 255     


His Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val 
            260                 265                 270         


Arg Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu 
        275                 280                 285             


Ile Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu 
    290                 295                 300                 


Asn Ser Tyr Trp Arg Asn Gln Asn Pro Gly Ser Leu Leu Gln Leu Pro 
305                 310                 315                 320 


His Thr Glu Ala Leu Leu Val Leu Cys Tyr Ser Ile Val Glu Asn Thr 
                325                 330                 335     


Cys Ile Ile Thr Pro Thr Ala Lys Ala Trp Lys Tyr Met Glu Glu Glu 
            340                 345                 350         


Ile Leu Gly Phe Gly Lys Ser Val Cys Asp Ser Leu Gly Arg Arg His 
        355                 360                 365             


Met Ser Thr Cys Ala Leu Cys Asp Phe Cys Ser Leu Lys Leu Glu Gln 
    370                 375                 380                 


Cys His Ser Glu Ala Ser Leu Gln Arg Gln Gln Cys Asp Thr Ser His 
385                 390                 395                 400 


Lys Thr Pro Phe Val Ser Pro Leu Leu Ala Ser Gln Ser Leu Ser Ile 
                405                 410                 415     


Gly Asn Gln Val Gly Ser Pro Glu Ser Gly Arg Phe Tyr Gly Leu Asp 
            420                 425                 430         


Leu Tyr Gly Gly Leu His Met Asp Phe Trp Cys Ala Arg Leu Ala Thr 
        435                 440                 445             


Lys Gly Cys Glu Asp Val Arg Val Ser Gly Trp Leu Gln Thr Glu Phe 
    450                 455                 460                 


Leu Ser Phe Gln Asp Gly Asp Phe Pro Thr Lys Ile Cys Asp Thr Asp 
465                 470                 475                 480 


Tyr Ile Gln Tyr Pro Asn Tyr Cys Ser Phe Lys Ser Gln Gln Cys Leu 
                485                 490                 495     


Met Arg Asn Arg Asn Arg Lys Val Ser Arg Met Arg Cys Leu Gln Asn 
            500                 505                 510         


Glu Thr Tyr Ser Ala Leu Ser Pro Gly Lys Ser Glu Asp Val Val Leu 
        515                 520                 525             


Arg Trp Ser Gln Glu Phe Ser Thr Leu Thr Leu Gly Gln Phe Gly 
    530                 535                 540             


<210>  420
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ACRBP__Homo_sapiens__AAH33010

<400>  420
augaggaagc cagccgcugg cuuccuuccc ucacuccuga aggugcugcu ccugccucug       60

gcaccugccg cagcccagga uucgacucag gccuccacuc caggcagccc ucucucuccu      120

accgaauacg aacgcuucuu cgcacugcug acuccaaccu ggaaggcaga gacuaccugc      180

cgucuccgug caacccacgg cugccggaau cccacacucg uccagcugga ccaauaugaa      240

aaccacggcu uagugcccga uggugcuguc ugcuccaacc ucccuuaugc cuccugguuu      300

gagucuuucu gccaguucac ucacuaccgu ugcuccaacc acgucuacua ugccaagaga      360

guccuguguu cccagccagu cucuauucuc ucaccuaaca cucucaagga gauagaagcu      420

ucagcugaag ucucacccac cacgaugacc ucccccaucu caccccacuu cacagugaca      480

gaacgccaga ccuuccagcc cuggccugag aggcucagca acaacgugga agagcuccua      540

caauccuccu ugucccuggg aggccaggag caagcgccag agcacaagca ggagcaagga      600

guggagcaca ggcaggagcc gacacaagaa cacaagcagg aagaggggca gaaacaggaa      660

gagcaagaag aggaacagga agaggaggga aagcaggaag aaggacaggg gacuaaggag      720

ggacgggagg cugugucuca gcugcagaca gacucagagc ccaaguuuca cucugaaucu      780

cuaucuucua acccuuccuc uuuugcuccc cggguacgag aaguagaguc uacuccuaug      840

auaauggaga acauccagga gcucauucga ucagcccagg aaauagauga aaugaaugaa      900

auauaugaug agaacuccua cuggagaaac caaaacccug gcagccuccu gcagcugccc      960

cacacagagg ccuugcuggu gcugugcuau ucgaucgugg agaauaccug caucauaacc     1020

cccacagcca aggccuggaa guacauggag gaggagaucc uugguuucgg gaagucgguc     1080

ugugacagcc uugggcggcg acacaugucu accugugccc ucugugacuu cugcuccuug     1140

aagcuggagc agugccacuc agaggccagc cugcagcggc aacaaugcga caccucccac     1200

aagacucccu uugucagccc cuugcuugcc ucccagagcc uguccaucgg caaccaggua     1260

ggguccccag aaucaggccg cuuuuacggg cuggauuugu acggugggcu ccacauggac     1320

uucuggugug cccggcuugc cacgaaaggc ugugaagaug uccgagucuc uggguggcuc     1380

cagacugagu uccuuagcuu ccaggauggg gauuucccua ccaagauuug ugacacagac     1440

uauauccagu acccaaacua cuguuccuuc aaaagccagc agugucugau gagaaaccgc     1500

aaucggaagg ugucccgcau gagaugucug cagaaugaga cuuacagugc gcugagcccu     1560

ggcaaaagug aggacguugu gcuucgaugg agccaggagu ucagcaccuu gacucuaggc     1620

caguucggau ga                                                         1632


<210>  421
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ACRBP__Homo_sapiens__AAH33010

<400>  421
augcgcaagc ccgccgccgg cuuccugccg agccuccuga aggugcugcu ccugccccug       60

gcgcccgccg ccgcccagga cuccacccag gccagcaccc ccgggucccc gcucagcccc      120

acggaguacg agcgguucuu cgcgcugcug acccccaccu ggaaggccga gaccacgugc      180

cgccuccggg ccacccacgg cugccgcaac cccacccugg uccagcugga ccaguacgag      240

aaccacgggc ucgugccgga cggcgccgug ugcuccaacc ugcccuacgc gagcugguuc      300

gaguccuucu gccaguucac ccacuaccgg ugcagcaacc acgucuacua cgccaagcgc      360

gugcugugcu cccagcccgu gagcauccuc ucccccaaca cgcugaagga gaucgaggcc      420

agcgccgagg ucuccccgac caccaugacc agccccauca gcccccacuu cacggugacc      480

gagcggcaga ccuuccagcc cuggccggag cgccugagca acaacgugga ggagcuccug      540

caguccagcc ugucccucgg gggccaggag caggcccccg agcacaagca ggagcagggc      600

gucgagcacc ggcaggagcc cacccaggag cacaagcagg aggaggggca gaagcaggag      660

gagcaggagg aggagcagga ggaggagggc aagcaggagg aggggcaggg cacgaaggag      720

gggcgcgagg cggugagcca gcugcagacc gacagcgagc ccaaguucca cuccgagagc      780

cuguccagca acccguccag cuucgcgccc cgggugcgcg aggucgaguc cacccccaug      840

aucauggaga acauccagga gcucauccgg agcgcccagg agaucgacga gaugaacgag      900

aucuacgacg agaacuccua cuggcgcaac cagaaccccg gcagccugcu gcagcucccg      960

cacaccgagg cccugcuggu gcucugcuac uccaucgugg agaacacgug caucaucacc     1020

cccaccgcca aggccuggaa guacauggag gaggagaucc ugggcuucgg gaaguccguc     1080

ugcgacuccc ugggccggcg ccacaugagc acgugcgccc ucugcgacuu cugcucccug     1140

aagcuggagc agugccacag cgaggccucc cuccagcggc agcagugcga caccagccac     1200

aagacccccu ucgugagccc ccugcuggcc ucccagagcc ucuccaucgg gaaccaggug     1260

ggcagcccgg aguccggccg cuucuacggg cuggaccugu acggcgggcu ccacauggac     1320

uucuggugcg cccggcuggc gaccaagggc ugcgaggacg uccgcgugag cggguggcug     1380

cagaccgagu uccucuccuu ccaggacggc gacuucccca cgaagaucug cgacaccgac     1440

uacauccagu accccaacua cugcagcuuc aagucccagc agugccugau gcggaaccgc     1500

aaccgcaagg ugagccggau gcgcugccug cagaacgaga ccuacuccgc ccucagcccg     1560

ggcaaguccg aggacgucgu gcugcggugg agccaggagu ucuccacccu gacgcugggg     1620

caguucggcu ga                                                         1632


<210>  422
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ACRBP__Homo_sapiens__AAH33010

<400>  422
augcgcaagc ccgccgccgg cuuccucccc ucccuccuca agguccuccu ccucccccuc       60

gcccccgccg ccgcccagga cuccacccag gccuccaccc ccggcucccc ccucuccccc      120

accgaguacg agcgcuucuu cgcccuccuc acccccaccu ggaaggccga gaccaccugc      180

cgccuccgcg ccacccacgg cugccgcaac cccacccucg uccagcucga ccaguacgag      240

aaccacggcc ucguccccga cggcgccguc ugcuccaacc uccccuacgc cuccugguuc      300

gaguccuucu gccaguucac ccacuaccgc ugcuccaacc acgucuacua cgccaagcgc      360

guccucugcu cccagcccgu cuccauccuc ucccccaaca cccucaagga gaucgaggcc      420

uccgccgagg ucucccccac caccaugacc ucccccaucu ccccccacuu caccgucacc      480

gagcgccaga ccuuccagcc cuggcccgag cgccucucca acaacgucga ggagcuccuc      540

caguccuccc ucucccucgg cggccaggag caggcccccg agcacaagca ggagcagggc      600

gucgagcacc gccaggagcc cacccaggag cacaagcagg aggagggcca gaagcaggag      660

gagcaggagg aggagcagga ggaggagggc aagcaggagg agggccaggg caccaaggag      720

ggccgcgagg ccgucuccca gcuccagacc gacuccgagc ccaaguucca cuccgagucc      780

cucuccucca accccuccuc cuucgccccc cgcguccgcg aggucgaguc cacccccaug      840

aucauggaga acauccagga gcucauccgc uccgcccagg agaucgacga gaugaacgag      900

aucuacgacg agaacuccua cuggcgcaac cagaaccccg gcucccuccu ccagcucccc      960

cacaccgagg cccuccucgu ccucugcuac uccaucgucg agaacaccug caucaucacc     1020

cccaccgcca aggccuggaa guacauggag gaggagaucc ucggcuucgg caaguccguc     1080

ugcgacuccc ucggccgccg ccacaugucc accugcgccc ucugcgacuu cugcucccuc     1140

aagcucgagc agugccacuc cgaggccucc cuccagcgcc agcagugcga caccucccac     1200

aagacccccu ucgucucccc ccuccucgcc ucccaguccc ucuccaucgg caaccagguc     1260

ggcucccccg aguccggccg cuucuacggc cucgaccucu acggcggccu ccacauggac     1320

uucuggugcg cccgccucgc caccaagggc ugcgaggacg uccgcgucuc cggcuggcuc     1380

cagaccgagu uccucuccuu ccaggacggc gacuucccca ccaagaucug cgacaccgac     1440

uacauccagu accccaacua cugcuccuuc aagucccagc agugccucau gcgcaaccgc     1500

aaccgcaagg ucucccgcau gcgcugccuc cagaacgaga ccuacuccgc ccucuccccc     1560

ggcaaguccg aggacgucgu ccuccgcugg ucccaggagu ucuccacccu cacccucggc     1620

caguucggcu ga                                                         1632


<210>  423
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ACRBP__Homo_sapiens__AAH33010

<400>  423
augagaaagc ccgccgcugg cuuccugccu agccuccuua aagugcuguu guuaccacug       60

gcaccggccg cggcucagga cuccacccaa gccucuacac ccgggucacc ucuaagucca      120

acugaguacg aaagguuuuu cgcacuccug acgcccaccu ggaaggccga gacaacuugc      180

cggcuucgcg cuacccacgg augucgaaac ccuacacugg uccaguugga ucaguaugaa      240

aaucaugguc ucguuccaga cggcgcagug ugcagcaacc ugcccuacgc cuccugguuu      300

gagucuuucu gucaguuuac ccacuaucgu ugcucgaauc auguauacua ugcuaaaaga      360

gugcuguguu cacaaccugu cagcauccuc aguccaaaca cuuuaaagga aauugaggcc      420

uccgcggagg ugucuccgac aaccaugacg agccccauau ccccucacuu cacuguuacc      480

gaaaggcaga cauuucagcc auggcccgag cggcugucaa auaacgugga agaacuuuug      540

cagaguagcc ugucucuagg gggacaagag caggcaccug aacauaaaca ggagcagggc      600

gucgaacacc gccaagagcc aacucaggaa cacaagcagg aggaggguca aaagcaggag      660

gagcaggaag aggaacagga ggaggaaggg aaacaagagg aaggacaggg caccaaggag      720

ggcagagaag ccguguccca gcuccagaca gauucagagc ccaaauucca uagcgagagu      780

cugucuucca auccgagcuc guuugcuccu aggguacggg aaguugaguc uacccccaug      840

aucauggaaa acauucaaga gcuuauccgc uccgcccagg agauugacga aaugaaugag      900

aucuacgaug aaaacucaua uuggcgaaau cagaacccag ggagucuguu gcagcucccu      960

cacacggagg cacuguuagu gcugugcuac agcauagucg aaaauacuug uaucauuaca     1020

cccaccgcua aggccuggaa auacauggag gaggaaaucc ucggauucgg uaaguccgug     1080

ugcgacucuc uuggcagaag gcauaugagc acuugugcgc ugugcgauuu uuguucauug     1140

aagcuagagc aaugccacag ugaagccucc cugcagcggc agcagugcga cacaagccac     1200

aaaaccccau ucgugucucc ccuccuggca ucacaaaguc uuagcauugg gaaccagguc     1260

ggauccccug agucuggccg uuuuuauggu cuggauuugu acgggggacu ccauauggac     1320

uucuggugug cucgccuggc cacgaagggc ugcgaagaug uuagaguguc gggcugguua     1380

cagaccgagu uccugagcuu ucaagacggg gauuucccaa caaaaaucug ugacacugac     1440

uauauacagu acccgaauua uugcuccuuu aagucacagc agugucuaau gaggaaccgg     1500

aaccgaaaag uaagucgcau gagaugccuc caaaaugaga ccuacucugc ucugagcccc     1560

ggaaaguccg aagauguggu ccuuaggugg ucacaggagu ucagcacauu gacucugggu     1620

caguuuggcu ga                                                         1632


<210>  424
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ACRBP__Homo_sapiens__AAH33010

<400>  424
augagaaagc ccgccgccgg cuuccugccc agccugcuga aggugcugcu gcugccccug       60

gcccccgccg ccgcccagga cagcacccag gccagcaccc ccggcagccc ccugagcccc      120

accgaguacg agagauucuu cgcccugcug acccccaccu ggaaggccga gaccaccugc      180

agacugagag ccacccacgg cugcagaaac cccacccugg ugcagcugga ccaguacgag      240

aaccacggcc uggugcccga cggcgccgug ugcagcaacc ugcccuacgc cagcugguuc      300

gagagcuucu gccaguucac ccacuacaga ugcagcaacc acguguacua cgccaagaga      360

gugcugugca gccagcccgu gagcauccug agccccaaca cccugaagga gaucgaggcc      420

agcgccgagg ugagccccac caccaugacc agccccauca gcccccacuu caccgugacc      480

gagagacaga ccuuccagcc cuggcccgag agacugagca acaacgugga ggagcugcug      540

cagagcagcc ugagccuggg cggccaggag caggcccccg agcacaagca ggagcagggc      600

guggagcaca gacaggagcc cacccaggag cacaagcagg aggagggcca gaagcaggag      660

gagcaggagg aggagcagga ggaggagggc aagcaggagg agggccaggg caccaaggag      720

ggcagagagg ccgugagcca gcugcagacc gacagcgagc ccaaguucca cagcgagagc      780

cugagcagca accccagcag cuucgccccc agagugagag agguggagag cacccccaug      840

aucauggaga acauccagga gcugaucaga agcgcccagg agaucgacga gaugaacgag      900

aucuacgacg agaacagcua cuggagaaac cagaaccccg gcagccugcu gcagcugccc      960

cacaccgagg cccugcuggu gcugugcuac agcaucgugg agaacaccug caucaucacc     1020

cccaccgcca aggccuggaa guacauggag gaggagaucc ugggcuucgg caagagcgug     1080

ugcgacagcc ugggcagaag acacaugagc accugcgccc ugugcgacuu cugcagccug     1140

aagcuggagc agugccacag cgaggccagc cugcagagac agcagugcga caccagccac     1200

aagacccccu ucgugagccc ccugcuggcc agccagagcc ugagcaucgg caaccaggug     1260

ggcagccccg agagcggcag auucuacggc cuggaccugu acggcggccu gcacauggac     1320

uucuggugcg ccagacuggc caccaagggc ugcgaggacg ugagagugag cggcuggcug     1380

cagaccgagu uccugagcuu ccaggacggc gacuucccca ccaagaucug cgacaccgac     1440

uacauccagu accccaacua cugcagcuuc aagagccagc agugccugau gagaaacaga     1500

aacagaaagg ugagcagaau gagaugccug cagaacgaga ccuacagcgc ccugagcccc     1560

ggcaagagcg aggacguggu gcugagaugg agccaggagu ucagcacccu gacccugggc     1620

caguucggcu ga                                                         1632


<210>  425
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ACRBP__Homo_sapiens__AAH33010

<400>  425
augagaaagc ccgccgcugg cuuccugccu agccuccuga aagugcuucu gcucccgcug       60

gcccccgcgg cugcccagga cuccacccaa gccucuacac cugggagccc ccuuuccccu      120

acggaguacg aacgguuuuu cgcucugcuc acccccacau ggaaggccga gaccacaugc      180

cgccugagag cuacccacgg augucggaac ccuacacugg uccagcucga ucaguaugaa      240

aaucauggcc ugguuccgga cggggccgug ugcucuaacc uucccuacgc gagcugguuu      300

gaguccuucu gucaguuuac ccacuaucgc ugcucuaauc auguguacua ugccaaaaga      360

guccugugua gccaaccugu guccauccuc agccccaaca cgcugaagga aauugaggcu      420

ucugccgagg uuuccccuac cacaaugacc agccccaucu cuccgcacuu cacagugacc      480

gaacggcaga cguuucagcc uuggcccgag cgccuuucca auaacgucga agaacugcuc      540

cagagcucuc ugucccuggg aggccaagag caggcuccug aacauaaaca ggagcagggg      600

guggaacaca gacaagagcc cacacaggaa cacaagcagg aggagggaca aaagcaggag      660

gagcaggaag aggaacagga ggaggaaggc aaacaagagg aaggccaggg gaccaaggag      720

ggacgggaag ccguuagcca gcuccagaca gauuccgagc ccaaauucca uucugagagc      780

cuguccagca auccuucuuc cuuugcgccg cgcgugagag aagucgagag cacccccaug      840

auuauggaaa acauccaaga gcuuauucgg ucugcccagg agaucgacga aaugaaugag      900

aucuacgaug aaaacagcua uuggcgcaau cagaacccug gcucccugcu ccagcugccc      960

cacaccgagg cccuucuggu gcucugcuac ucuauugugg aaaauacaug uaucauuacg     1020

ccuaccgcua aggcuuggaa auacauggag gaggaaaucc ugggguucgg aaagagcguc     1080

ugcgacuccc ugggcagacg gcauaugagc acaugugccc ucugcgauuu uuguucucug     1140

aaacuugagc aaugccacuc cgaagccagc cugcagcgcc agcagugcga caccucucac     1200

aagacacccu ucguuucccc gcuccuggcu agccaauccc uuucuauugg gaaccaggug     1260

ggaagcccug aguccggcag auuuuauggc cuggaucucu acgggggacu gcauauggac     1320

uucuggugug cgcggcuggc caccaagggc ugcgaagaug ugagagucuc uggguggcuc     1380

cagacggagu uccugagcuu ucaagacgga gauuucccca caaaaaucug ugacaccgac     1440

uauauucagu acccuaauua uugcuccuuu aagagccagc agugucuuau gcgcaaccgg     1500

aacagaaaag ugucucgcau gcggugccug caaaaugaga ccuacuccgc ucucagcccc     1560

ggcaagucug aagauguugu gcugagaugg ucccaggagu ucagcacacu gacccuuggg     1620

caguuuggau ga                                                         1632


<210>  426
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AFP__Homo_sapiens__P02771

<400>  426

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  427
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  AFP__Homo_sapiens__AAB58754

<400>  427
augaaguggg uggaaucaau uuuuuuaauu uuccuacuaa auuuuacuga auccagaaca       60

cugcauagaa augaauaugg aauagcuucc auauuggauu cuuaccaaug uacugcagag      120

auaaguuuag cugaccuggc uaccauauuu uuugcccagu uuguucaaga agccacuuac      180

aaggaaguaa gcaaaauggu gaaagaugca uugacugcaa uugagaaacc cacuggagau      240

gaacagucuu caggguguuu agaaaaccag cuaccugccu uucuggaaga acuuugccau      300

gagaaagaaa uuuuggagaa guacggacau ucagacugcu gcagccaaag ugaagaggga      360

agacauaacu guuuucuugc acacaaaaag cccacuccag caucgauccc acuuuuccaa      420

guuccagaac cugucacaag cugugaagca uaugaagaag acagggagac auucaugaac      480

aaauucauuu augagauagc aagaaggcau cccuuccugu augcaccuac aauucuucuu      540

ugggcugcuc gcuaugacaa aauaauucca ucuugcugca aagcugaaaa ugcaguugaa      600

ugcuuccaaa caaaggcagc aacaguuaca aaagaauuaa gagaaagcag cuuguuaaau      660

caacaugcau gugcaguaau gaaaaauuuu gggacccgaa cuuuccaagc cauaacuguu      720

acuaaacuga gucagaaguu uaccaaaguu aauuuuacug aaauccagaa acuaguccug      780

gauguggccc auguacauga gcacuguugc agaggagaug ugcuggauug ucugcaggau      840

ggggaaaaaa ucauguccua cauauguucu caacaagaca cucugucaaa caaaauaaca      900

gaaugcugca aacugaccac gcuggaacgu ggucaaugua uaauucaugc agaaaaugau      960

gaaaaaccug aaggucuauc uccaaaucua aacagguuuu uaggagauag agauuuuaac     1020

caauuuucuu caggggaaaa aaauaucuuc uuggcaaguu uuguucauga auauucaaga     1080

agacauccuc agcuugcugu cucaguaauu cuaagaguug cuaaaggaua ccaggaguua     1140

uuggagaagu guuuccagac ugaaaacccu cuugaaugcc aagauaaagg agaagaagaa     1200

uuacagaaau acauccagga gagccaagca uuggcaaagc gaagcugcgg ccucuuccag     1260

aaacuaggag aauauuacuu acaaaaugcg uuucucguug cuuacacaaa gaaagccccc     1320

cagcugaccu cgucggagcu gauggccauc accagaaaaa uggcagccac agcagccacu     1380

uguugccaac ucagugagga caaacuauug gccuguggcg agggagcggc ugacauuauu     1440

aucggacacu uauguaucag acaugaaaug acuccaguaa acccuggugu uggccagugc     1500

ugcacuucuu cauaugccaa caggaggcca ugcuucagca gcuugguggu ggaugaaaca     1560

uaugucccuc cugcauucuc ugaugacaag uucauuuucc auaaggaucu gugccaagcu     1620

caggguguag cgcugcaaac gaugaagcaa gaguuucuca uuaaccuugu gaagcaaaag     1680

ccacaaauaa cagaggaaca acuugaggcu gucauugcag auuucucagg ccuguuggag     1740

aaaugcugcc aaggccagga acaggaaguc ugcuuugcug aagagggaca aaaacugauu     1800

ucaaaaacuc gugcugcuuu gggaguuuaa                                      1830


<210>  428
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       AFP__Homo_sapiens__AAB58754

<400>  428
augaaguggg uggagagcau cuuccugauc uuccuccuga acuucaccga gucccgcacc       60

cugcaccgga acgaguacgg caucgccagc auccucgacu ccuaccagug cacggccgag      120

aucagccugg cggaccuggc caccaucuuc uucgcccagu ucguccagga ggccaccuac      180

aaggaggugu ccaagauggu gaaggacgcc cucaccgcga ucgagaagcc cacgggggac      240

gagcagagcu ccggcugccu ggagaaccag cugcccgccu uccucgagga gcugugccac      300

gagaaggaga uccuggagaa guacgggcac agcgacugcu gcucccagag cgaggagggc      360

cgccacaacu gcuuccucgc ccacaagaag cccacccccg ccuccauccc ccuguuccag      420

gucccggagc ccgugaccag cugcgaggcg uacgaggagg accgggagac cuucaugaac      480

aaguucaucu acgagaucgc ccgccggcac cccuuccugu acgcccccac gauccuccug      540

ugggccgccc gcuacgacaa gaucaucccg uccugcugca aggcggagaa cgccguggag      600

ugcuuccaga ccaaggccgc caccgucacc aaggagcugc gggagagcuc ccuccugaac      660

cagcacgccu gcgcggugau gaagaacuuc gggacgcgca ccuuccaggc caucaccgug      720

accaagcuga gccagaaguu cacgaagguc aacuucaccg agauccagaa gcucgugcug      780

gacguggccc acguccacga gcacugcugc cggggcgacg ugcuggacug ccuccaggac      840

ggcgagaaga ucauguccua caucugcagc cagcaggaca cccuguccaa caagaucacc      900

gagugcugca agcugacgac ccucgagcgc gggcagugca ucauccacgc cgagaacgac      960

gagaagcccg agggccugag ccccaaccug aaccgguucc ucggggaccg cgacuucaac     1020

caguucagcu ccggcgagaa gaacaucuuc cuggccagcu ucgugcacga guacucccgg     1080

cgccaccccc agcuggcggu cagcgugauc cuccgggugg ccaaggggua ccaggagcug     1140

cuggagaagu gcuuccagac cgagaacccg cucgagugcc aggacaaggg cgaggaggag     1200

cugcagaagu acauccagga gucccaggcc cuggccaagc gcagcugcgg ccucuuccag     1260

aagcuggggg aguacuaccu gcagaacgcc uuccucgucg cguacaccaa gaaggcgccc     1320

cagcugacgu ccagcgagcu gauggccauc acccggaaga uggccgccac cgccgcgacc     1380

ugcugccagc ucuccgagga caagcugcug gccugcggcg agggggccgc cgacaucauc     1440

aucggccacc ucugcauccg ccacgagaug acgcccguga accccggcgu ggggcagugc     1500

ugcaccagcu ccuacgccaa ccggcgcccg ugcuucagcu cccuggucgu ggacgagacc     1560

uacgugccgc ccgccuucag cgacgacaag uucaucuucc acaaggaccu gugccaggcc     1620

cagggcgucg cccugcagac caugaagcag gaguuccuca ucaaccuggu gaagcagaag     1680

ccccagauca cggaggagca gcuggaggcg gucaucgccg acuucuccgg gcuccuggag     1740

aagugcugcc agggccagga gcaggaggug ugcuucgccg aggaggggca gaagcugauc     1800

agcaagaccc gggccgcccu cggcguguga                                      1830


<210>  429
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       AFP__Homo_sapiens__AAB58754

<400>  429
augaaguggg ucgaguccau cuuccucauc uuccuccuca acuucaccga gucccgcacc       60

cuccaccgca acgaguacgg caucgccucc auccucgacu ccuaccagug caccgccgag      120

aucucccucg ccgaccucgc caccaucuuc uucgcccagu ucguccagga ggccaccuac      180

aaggaggucu ccaagauggu caaggacgcc cucaccgcca ucgagaagcc caccggcgac      240

gagcaguccu ccggcugccu cgagaaccag cuccccgccu uccucgagga gcucugccac      300

gagaaggaga uccucgagaa guacggccac uccgacugcu gcucccaguc cgaggagggc      360

cgccacaacu gcuuccucgc ccacaagaag cccacccccg ccuccauccc ccucuuccag      420

guccccgagc ccgucaccuc cugcgaggcc uacgaggagg accgcgagac cuucaugaac      480

aaguucaucu acgagaucgc ccgccgccac cccuuccucu acgcccccac cauccuccuc      540

ugggccgccc gcuacgacaa gaucaucccc uccugcugca aggccgagaa cgccgucgag      600

ugcuuccaga ccaaggccgc caccgucacc aaggagcucc gcgaguccuc ccuccucaac      660

cagcacgccu gcgccgucau gaagaacuuc ggcacccgca ccuuccaggc caucaccguc      720

accaagcucu cccagaaguu caccaagguc aacuucaccg agauccagaa gcucguccuc      780

gacgucgccc acguccacga gcacugcugc cgcggcgacg uccucgacug ccuccaggac      840

ggcgagaaga ucauguccua caucugcucc cagcaggaca cccucuccaa caagaucacc      900

gagugcugca agcucaccac ccucgagcgc ggccagugca ucauccacgc cgagaacgac      960

gagaagcccg agggccucuc ccccaaccuc aaccgcuucc ucggcgaccg cgacuucaac     1020

caguucuccu ccggcgagaa gaacaucuuc cucgccuccu ucguccacga guacucccgc     1080

cgccaccccc agcucgccgu cuccgucauc cuccgcgucg ccaagggcua ccaggagcuc     1140

cucgagaagu gcuuccagac cgagaacccc cucgagugcc aggacaaggg cgaggaggag     1200

cuccagaagu acauccagga gucccaggcc cucgccaagc gcuccugcgg ccucuuccag     1260

aagcucggcg aguacuaccu ccagaacgcc uuccucgucg ccuacaccaa gaaggccccc     1320

cagcucaccu ccuccgagcu cauggccauc acccgcaaga uggccgccac cgccgccacc     1380

ugcugccagc ucuccgagga caagcuccuc gccugcggcg agggcgccgc cgacaucauc     1440

aucggccacc ucugcauccg ccacgagaug acccccguca accccggcgu cggccagugc     1500

ugcaccuccu ccuacgccaa ccgccgcccc ugcuucuccu cccucgucgu cgacgagacc     1560

uacguccccc ccgccuucuc cgacgacaag uucaucuucc acaaggaccu cugccaggcc     1620

cagggcgucg cccuccagac caugaagcag gaguuccuca ucaaccucgu caagcagaag     1680

ccccagauca ccgaggagca gcucgaggcc gucaucgccg acuucuccgg ccuccucgag     1740

aagugcugcc agggccagga gcaggagguc ugcuucgccg aggagggcca gaagcucauc     1800

uccaagaccc gcgccgcccu cggcgucuga                                      1830


<210>  430
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       AFP__Homo_sapiens__AAB58754

<400>  430
augaaguggg uggagagcau cuuccugauu uuucuccuua acuucaccga auccagaaca       60

cugcacagga augaguacgg cauagccucu aucuuggacu cauaucagug cacugcugaa      120

auuaguuuag cagaucuggc cacgaucuuu uucgcgcaau uuguccagga ggcuaccuac      180

aaagaaguua gcaagauggu gaaagacgcc cuaacagcaa uugagaagcc cacuggggau      240

gagcaguccu cuggaugucu cgaaaaccag cugccugccu uccuugagga acugugccau      300

gagaaagaga ucuuggaaaa guauggucac ucggacuguu gcucacaaag cgaggaaggc      360

cggcauaauu guuuucucgc ucacaagaaa ccaaccccgg caaguauacc ccuguuccag      420

guaccugagc cagugacauc cugcgaagcc uacgaggagg aucgcgaaac cuuuaugaac      480

aaguucaucu augagauugc ucgacgucau cccuuucugu acgccccuac uauccucuua      540

ugggcggcaa gauaugacaa aauuauccca ucuuguugca aggccgaaaa ugcugucgag      600

uguuuccaga caaaagccgc aaccgugacg aaggaacuga gggagagcuc ccuuuugaac      660

cagcacgcuu gcgccguuau gaagaauuuu gggacucgga ccuuccaagc gauaacagug      720

acuaaacugu cacagaaguu caccaaaguc aacuuuacag agauucagaa gcuagugcuc      780

gauguagccc acguucauga acacuguugc cgcggagacg ugcuggauug ccuucaggac      840

ggcgagaaaa ucaugaguua cauuuguagc caacaggaua cccugucuaa uaagaucacg      900

gaaugcugua aauugacuac acucgagaga ggucagugca ucauucaugc agaaaacgac      960

gagaagcccg aggggcuguc cccuaauuua aacagguucc ugggagaucg ggacuuuaau     1020

caauucucaa gcggcgaaaa gaacauauuu cucgcuaguu ucguccacga guacucucgc     1080

cgacacccac agcuugccgu guccgugauc cugagagucg cuaaaggcua ucaggaauug     1140

cuagagaagu guuuucagac cgagaauccg cuggaaugcc aagacaaagg ggaggaagaa     1200

cuccagaagu acauucagga aagccaggcc cuggcaaaaa ggucgugugg acuuuuccaa     1260

aagcugggug aguauuacuu gcagaacgcc uuucucguug cuuauacuaa gaaagcgccc     1320

cagcugacau cuuccgaguu aauggcaauc acccggaaga uggccgcuac ggccgcaacc     1380

ugcugucagc ugucagaaga uaaacuacuc gccugcggcg agggggcugc cgacauaauu     1440

aucggacauc uguguauccg ucacgaaaug acaccuguga acccaggcgu aggucaaugc     1500

ugcaccagua gcuacgcaaa ucgcagaccc uguuucuccu cucuuguggu cgaugagacu     1560

uaugugccuc cagcguuuag cgacgauaag uucauuuuuc auaaagacuu gugccaggcu     1620

caggggguug cccugcagac aaugaagcaa gaguuccuca ucaaccuggu gaagcagaaa     1680

ccccagauua cugaggagca acuugaagca gucauagccg auuucucagg acuguuggag     1740

aaguguugcc agggccagga acaggaggug uguuuugcug aagagggcca aaaacucauc     1800

aguaagacca gggccgcacu ggggguauga                                      1830


<210>  431
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       AFP__Homo_sapiens__AAB58754

<400>  431
augaaguggg uggagagcau cuuccugauc uuccugcuga acuucaccga gagcagaacc       60

cugcacagaa acgaguacgg caucgccagc auccuggaca gcuaccagug caccgccgag      120

aucagccugg ccgaccuggc caccaucuuc uucgcccagu ucgugcagga ggccaccuac      180

aaggagguga gcaagauggu gaaggacgcc cugaccgcca ucgagaagcc caccggcgac      240

gagcagagca gcggcugccu ggagaaccag cugcccgccu uccuggagga gcugugccac      300

gagaaggaga uccuggagaa guacggccac agcgacugcu gcagccagag cgaggagggc      360

agacacaacu gcuuccuggc ccacaagaag cccacccccg ccagcauccc ccuguuccag      420

gugcccgagc ccgugaccag cugcgaggcc uacgaggagg acagagagac cuucaugaac      480

aaguucaucu acgagaucgc cagaagacac cccuuccugu acgcccccac cauccugcug      540

ugggccgcca gauacgacaa gaucaucccc agcugcugca aggccgagaa cgccguggag      600

ugcuuccaga ccaaggccgc caccgugacc aaggagcuga gagagagcag ccugcugaac      660

cagcacgccu gcgccgugau gaagaacuuc ggcaccagaa ccuuccaggc caucaccgug      720

accaagcuga gccagaaguu caccaaggug aacuucaccg agauccagaa gcuggugcug      780

gacguggccc acgugcacga gcacugcugc agaggcgacg ugcuggacug ccugcaggac      840

ggcgagaaga ucaugagcua caucugcagc cagcaggaca cccugagcaa caagaucacc      900

gagugcugca agcugaccac ccuggagaga ggccagugca ucauccacgc cgagaacgac      960

gagaagcccg agggccugag ccccaaccug aacagauucc ugggcgacag agacuucaac     1020

caguucagca gcggcgagaa gaacaucuuc cuggccagcu ucgugcacga guacagcaga     1080

agacaccccc agcuggccgu gagcgugauc cugagagugg ccaagggcua ccaggagcug     1140

cuggagaagu gcuuccagac cgagaacccc cuggagugcc aggacaaggg cgaggaggag     1200

cugcagaagu acauccagga gagccaggcc cuggccaaga gaagcugcgg ccuguuccag     1260

aagcugggcg aguacuaccu gcagaacgcc uuccuggugg ccuacaccaa gaaggccccc     1320

cagcugacca gcagcgagcu gauggccauc accagaaaga uggccgccac cgccgccacc     1380

ugcugccagc ugagcgagga caagcugcug gccugcggcg agggcgccgc cgacaucauc     1440

aucggccacc ugugcaucag acacgagaug acccccguga accccggcgu gggccagugc     1500

ugcaccagca gcuacgccaa cagaagaccc ugcuucagca gccugguggu ggacgagacc     1560

uacgugcccc ccgccuucag cgacgacaag uucaucuucc acaaggaccu gugccaggcc     1620

cagggcgugg cccugcagac caugaagcag gaguuccuga ucaaccuggu gaagcagaag     1680

ccccagauca ccgaggagca gcuggaggcc gugaucgccg acuucagcgg ccugcuggag     1740

aagugcugcc agggccagga gcaggaggug ugcuucgccg aggagggcca gaagcugauc     1800

agcaagacca gagccgcccu gggcguguga                                      1830


<210>  432
<211>  1830
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       AFP__Homo_sapiens__AAB58754

<400>  432
augaaguggg uggagagcau cuuccugauu uuucuccuga acuucaccga auccagaaca       60

cuucaccgga augaguacgg caucgccucu auucuggaca gcuaucagug cacggcugaa      120

aucucccucg ccgaucuggc gaccauuuuc uucgcucaau uuguccagga ggccacauac      180

aaagaaguuu cuaagauggu gaaagacgcc cuuaccgcua ucgagaagcc cacaggggau      240

gagcagagcu ccggaugucu ggaaaaccag cucccugccu uccuggagga acugugccau      300

gagaaagaga uccucgaaaa guauggccac ucugacuguu gcagccaauc cgaggaaggg      360

cgccauaauu guuuucuggc ucacaagaaa ccgacccccg ccagcauucc ucuuuuccag      420

gugcccgagc cugucacauc uugcgaagcg uacgaggagg auagagaaac cuuuaugaac      480

aaguucaucu augagauugc ccggcgccau cccuuucugu acgcuccuac gauccuccug      540

ugggccgcua gauaugacaa aauuaucccg uccuguugca aggccgaaaa ugcgguggag      600

uguuuccaga ccaaagccgc uacaguuacc aaggaacuuc gggagagcuc ucugcucaac      660

cagcacgccu gcgcugugau gaagaauuuu ggaacacgca ccuuccaagc cauuacgguc      720

acaaaacugu cccagaaguu caccaaagug aacuuuacag agauccagaa gcugguucuc      780

gauguggccc acguccauga acacuguugc agaggcgacg ugcuggauug ccuucaggac      840

ggggagaaaa ucaugagcua cauuuguucu caacaggaua cccuguccaa uaagaucacc      900

gaaugcugua aacucacaac gcuggagcgg ggacagugca uuauccaugc ugaaaacgac      960

gagaagcccg agggccuuag cccuaaucug aaccgcuucc ucggcgauag agacuuuaau     1020

caauucuccu cuggggaaaa gaacauuuuu cuggcgagcu ucgugcacga guacucccgg     1080

cgccaccccc agcuggccgu cagcguuauc cucagagugg cuaaaggaua ucaggaacug     1140

cuugagaagu guuuucagac cgagaauccu cuggaaugcc aagacaaagg cgaggaggaa     1200

cuccagaagu acauccagga aucucaggcc cuggccaaac gguccugugg gcuuuuccaa     1260

aagcugggag aguauuaccu ccagaacgcu uuucuggugg ccuauacaaa gaaagcgccc     1320

cagcugacca gcucugagcu cauggcuauu acacgcaaga uggccgccac cgcugccacg     1380

ugcugucagc ugagcgaaga uaaacuucug gcuugcggcg agggggccgc ggacaucauu     1440

aucggacauc ucuguauuag acacgaaaug acaccgguca acccuggcgu gggccaaugc     1500

ugcaccuccu cuuacgccaa ucggagaccc uguuucagcu cccugguugu ggaugagacc     1560

uaugucccuc ccgcuuuuag cgacgauaag uucaucuuuc auaaagaccu gugccaggcc     1620

cagggggugg cccuucagac aaugaagcaa gaauuucuca ucaaccuggu uaagcagaaa     1680

ccccagauua ccgaggagca acuggaagcu gugaucgcgg auuucucugg acuccuggag     1740

aaguguugcc agggccagga acaggagguc uguuuugccg aagaggggca aaaacuuauu     1800

uccaagacac gcgcugcccu gggaguguga                                      1830


<210>  433
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AKAP4__Homo_sapiens__Q5JQC9

<400>  433

Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr 
545                 550                 555                 560 


Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210>  434
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  AKAP4__Homo_sapiens__AAI26251

<400>  434
augauggcgu acucugauac uacaaugaug ucugaugaua uugacugguu acgcagccac       60

aggggugugu gcaagguaga ucucuacaac ccagaaggac agcaagauca ggaccggaaa      120

gugauaugcu uugucgaugu guccacccug aauguagaag auaaagauua caaggaugcu      180

gcuaguucca gcucagaagg caacuuaaac cugggaaguc uggaagaaaa agagauuauc      240

gugaucaagg acacugagaa gaaagaccag ucuaagacag agggaucugu augccuuuuc      300

aaacaagcuc ccucugaucc uguaaguguc cucaacuggc uucucaguga ucuccagaag      360

uaugccuugg guuuccaaca ugcacugagc cccucaaccu cuaccuguaa acauaaagua      420

ggagacacag agggcgaaua ucacagagca uccucugaga acugcuacag ugucuaugcc      480

gaucaaguga acauagauua uuugaugaac agaccucaaa accuacgucu agaaaugaca      540

gcagcuaaaa acaccaacaa uaaucaaagu ccuucagcuc cuccagccaa accuccuagc      600

acucagagag cagucauuuc cccugaugga gaauguucua uagaugaccu uuccuucuac      660

gucaaccgac uaucuucucu gguaauccag auggcccaua aggaaaucaa ggagaaguug      720

gaagguaaaa gcaaaugccu ucaucauuca aucuguccau ccccugggaa caaagagaga      780

aucagucccc gaacuccugc gagcaagauu gcuucugaaa uggccuauga agcuguggaa      840

cugacagcug cagaaaugcg uggcacugga gaggagucca gggaaggugg ccagaaaagc      900

uuucuauaua gcgaauuauc caacaagagc aaaaguggag acaaacagau gucccagaga      960

gagagcaaag aauuugcaga uuccaucagc aaggggcuca ugguuuaugc aaaucaggug     1020

gcaucugaca ugauggucuc ucucaugaag accuugaaag ugcacagcuc ugggaagcca     1080

auuccagcau cugugguccu gaagagggug uugcuaaggc acaccaagga gauugugucc     1140

gauuugauug auucuugcau gaagaaccug cauaauauua cugggguccu gaugacugac     1200

ucagacuuug ucucagcugu caagagaaau cuguucaacc aguggaaaca aaaugcuaca     1260

gacaucaugg aggccaugcu gaagcgcuug gucagugccc uuauagguga ggagaaggag     1320

acuaagucuc agagucuguc auaugcaucu uuaaaagcug ggucccauga ucccaaaugc     1380

aggaaucaga gucuugaauu cuccaccaug aaagcugaaa ugaaagagag ggacaaaggc     1440

aaaaugaaau cagacccaug caagucacug acuagugcug agaaagucgg ugaacacauu     1500

cucaaagagg gccuaaccau cuggaaccaa aagcaaggaa acucaugcaa gguggcuacc     1560

aaagcaugca gcaauaaaga ugagaaagga gaaaagauca augcuuccac agauucacug     1620

gccaaggacc ugauugucuc ugcccuuaag cugauccagu accaucugac ccagcagacu     1680

aagggcaaag auacauguga agaagacugu ccugguucca ccaugggcua uauggcucag     1740

aguacucaau augaaaagug uggagguggc caaagugcca aagcacuuuc agugaaacaa     1800

cuagaaucuc acagagcccc uggaccaucc accugucaaa aggagaacca acaccuggac     1860

ucccagaaaa uggauauguc aaacaucguu cuaaugcuga uucagaaacu gcuuaaugag     1920

aaccccuuca aaugugagga uccaugcgaa ggugagaaca aguguucuga gcccagggca     1980

agcaaagcag cuuccauguc caacagaucu gacaaagcgg aagaacaaug ccaggagcau     2040

caagaacuug acuguaccag ugggaugaag caagcgaacg ggcaauuuau agauaaacua     2100

guagaaucug ugaugaagcu cugccuuauc auggcuaagu auagcaacga uggggcagcc     2160

cuugcugagu uggaagaaca agcagccucg gcaaauaagc ccaauuucag gggcaccaga     2220

ugcauucaca guggugcaau gccacagaac uaucaagacu cucuuggaca ugaaguaauu     2280

gucaauaauc agugcucuac aaauagcuug cagaagcagc uccaggcugu ccugcagugg     2340

auugcagccu cccaguuuaa cgugcccaug cucuacuuca ugggagauaa ggauggacaa     2400

cuggaaaagc uuccucaggu uucagcuaaa gcagcagaga agggguacag uguaggaggu     2460

cuucuucaag aggucaugaa guuugccaag gaacggcaac cagaugaagc ugugggaaag     2520

guggccagga aacaguugcu ggacuggcug cucgcuaacc uguga                     2565


<210>  435
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       AKAP4__Homo_sapiens__AAI26251

<400>  435
augauggccu acagcgacac caccaugaug uccgacgaca ucgacuggcu gcgcagccac       60

cggggcgugu gcaaggucga ccucuacaac cccgaggggc agcaggacca ggaccgcaag      120

gugaucugcu ucguggacgu cuccacccug aacguggagg acaaggacua caaggacgcc      180

gcgagcucca gcuccgaggg caaccugaac cucgggagcc uggaggagaa ggagaucauc      240

gugaucaagg acaccgagaa gaaggaccag uccaagaccg agggcagcgu cugccuguuc      300

aagcaggccc cguccgaccc cgugagcgug cucaacuggc ugcuguccga ccuccagaag      360

uacgcccugg gguuccagca cgcccugagc cccuccacca gcacgugcaa gcacaagguc      420

ggcgacaccg agggcgagua ccaccgggcc uccagcgaga acugcuacuc cguguacgcg      480

gaccagguga acaucgacua ccucaugaac cgcccccaga accugcggcu ggagaugacc      540

gccgccaaga acaccaacaa caaccagagc ccgagcgccc cgcccgcgaa gccgcccucc      600

acgcagcgcg ccgucaucag ccccgacggg gagugcucca ucgacgaccu cagcuucuac      660

gugaaccggc uguccagccu ggugauccag auggcccaca aggagaucaa ggagaagcuc      720

gagggcaagu ccaagugccu gcaccacagc aucugccccu cccccgggaa caaggagcgc      780

aucagccccc ggacccccgc cuccaagauc gccagcgaga uggcguacga ggccgucgag      840

cugaccgccg ccgagaugcg cggcaccggg gaggaguccc gggagggcgg ccagaagucc      900

uuccucuaca gcgagcugag caacaagucc aagagcgggg acaagcagau gucccagcgc      960

gagagcaagg aguucgccga cagcaucucc aagggccuga ugguguacgc gaaccaggug     1020

gccagcgaca ugauggucuc ccucaugaag acgcugaagg ugcacagcuc cgggaagccc     1080

auccccgcca gcgugguccu gaagcgggug cuccugcgcc acaccaagga gaucgugucc     1140

gaccugaucg acagcugcau gaagaaccuc cacaacauca ccggcguccu gaugaccgac     1200

uccgacuucg ugagcgccgu caagcggaac cuguucaacc aguggaagca gaacgccacg     1260

gacaucaugg aggcgaugcu caagcgccug guguccgccc ugaucggcga ggagaaggag     1320

accaagagcc agucccucag cuacgccucc cugaaggccg ggagccacga cccgaagugc     1380

cggaaccagu cccuggaguu cagcaccaug aaggccgaga ugaaggagcg cgacaagggc     1440

aagaugaagu ccgaccccug caagagccuc accagcgcgg agaagguggg ggagcacauc     1500

cugaaggagg gccugacgau cuggaaccag aagcagggga acuccugcaa ggucgccacc     1560

aaggccugca gcaacaagga cgagaagggc gagaagauca acgccuccac cgacagccuc     1620

gcgaaggacc ugaucguguc cgcccugaag cucauccagu accaccugac ccagcagacg     1680

aagggcaagg acacgugcga ggaggacugc cccgggagca ccaugggcua cauggcccag     1740

uccacccagu acgagaagug cgggggcggg cagagcgcca aggcccuguc cgugaagcag     1800

cucgagagcc accgggcgcc cggcccgucc acgugccaga aggagaacca gcaccuggac     1860

agccagaaga uggacauguc caacaucguc cugaugcuga uccagaagcu ccugaacgag     1920

aaccccuuca agugcgagga ccccugcgag ggcgagaaca agugcagcga gccccgcgcc     1980

uccaaggccg ccagcauguc caaccggagc gacaaggccg aggagcagug ccaggagcac     2040

caggagcugg acugcaccag cgggaugaag caggcgaacg gccaguucau cgacaagcuc     2100

guggaguccg ugaugaagcu gugccugauc auggccaagu acagcaacga cggggccgcc     2160

cucgccgagc uggaggagca ggcggccucc gccaacaagc cgaacuuccg cggcacccgc     2220

ugcauccaca gcggggccau gccccagaac uaccaggacu cccugggcca cgaggucauc     2280

gugaacaacc agugcagcac caacucccuc cagaagcagc ugcaggcggu gcugcagugg     2340

aucgccgcca gccaguucaa cguccccaug cucuacuuca ugggcgacaa ggacgggcag     2400

cuggagaagc ugccccaggu guccgccaag gccgcggaga agggcuacag cgucgggggc     2460

cuccugcagg aggugaugaa guucgccaag gagcggcagc cggacgaggc cgugggcaag     2520

guggcccgca agcagcugcu cgacuggcug cuggccaacc ucuga                     2565


<210>  436
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       AKAP4__Homo_sapiens__AAI26251

<400>  436
augauggccu acuccgacac caccaugaug uccgacgaca ucgacuggcu ccgcucccac       60

cgcggcgucu gcaaggucga ccucuacaac cccgagggcc agcaggacca ggaccgcaag      120

gucaucugcu ucgucgacgu cuccacccuc aacgucgagg acaaggacua caaggacgcc      180

gccuccuccu ccuccgaggg caaccucaac cucggcuccc ucgaggagaa ggagaucauc      240

gucaucaagg acaccgagaa gaaggaccag uccaagaccg agggcuccgu cugccucuuc      300

aagcaggccc ccuccgaccc cgucuccguc cucaacuggc uccucuccga ccuccagaag      360

uacgcccucg gcuuccagca cgcccucucc cccuccaccu ccaccugcaa gcacaagguc      420

ggcgacaccg agggcgagua ccaccgcgcc uccuccgaga acugcuacuc cgucuacgcc      480

gaccagguca acaucgacua ccucaugaac cgcccccaga accuccgccu cgagaugacc      540

gccgccaaga acaccaacaa caaccagucc cccuccgccc cccccgccaa gccccccucc      600

acccagcgcg ccgucaucuc ccccgacggc gagugcucca ucgacgaccu cuccuucuac      660

gucaaccgcc ucuccucccu cgucauccag auggcccaca aggagaucaa ggagaagcuc      720

gagggcaagu ccaagugccu ccaccacucc aucugccccu cccccggcaa caaggagcgc      780

aucucccccc gcacccccgc cuccaagauc gccuccgaga uggccuacga ggccgucgag      840

cucaccgccg ccgagaugcg cggcaccggc gaggaguccc gcgagggcgg ccagaagucc      900

uuccucuacu ccgagcucuc caacaagucc aaguccggcg acaagcagau gucccagcgc      960

gaguccaagg aguucgccga cuccaucucc aagggccuca uggucuacgc caaccagguc     1020

gccuccgaca ugauggucuc ccucaugaag acccucaagg uccacuccuc cggcaagccc     1080

auccccgccu ccgucguccu caagcgcguc cuccuccgcc acaccaagga gaucgucucc     1140

gaccucaucg acuccugcau gaagaaccuc cacaacauca ccggcguccu caugaccgac     1200

uccgacuucg ucuccgccgu caagcgcaac cucuucaacc aguggaagca gaacgccacc     1260

gacaucaugg aggccaugcu caagcgccuc gucuccgccc ucaucggcga ggagaaggag     1320

accaaguccc agucccucuc cuacgccucc cucaaggccg gcucccacga ccccaagugc     1380

cgcaaccagu cccucgaguu cuccaccaug aaggccgaga ugaaggagcg cgacaagggc     1440

aagaugaagu ccgaccccug caagucccuc accuccgccg agaaggucgg cgagcacauc     1500

cucaaggagg gccucaccau cuggaaccag aagcagggca acuccugcaa ggucgccacc     1560

aaggccugcu ccaacaagga cgagaagggc gagaagauca acgccuccac cgacucccuc     1620

gccaaggacc ucaucgucuc cgcccucaag cucauccagu accaccucac ccagcagacc     1680

aagggcaagg acaccugcga ggaggacugc cccggcucca ccaugggcua cauggcccag     1740

uccacccagu acgagaagug cggcggcggc caguccgcca aggcccucuc cgucaagcag     1800

cucgaguccc accgcgcccc cggccccucc accugccaga aggagaacca gcaccucgac     1860

ucccagaaga uggacauguc caacaucguc cucaugcuca uccagaagcu ccucaacgag     1920

aaccccuuca agugcgagga ccccugcgag ggcgagaaca agugcuccga gccccgcgcc     1980

uccaaggccg ccuccauguc caaccgcucc gacaaggccg aggagcagug ccaggagcac     2040

caggagcucg acugcaccuc cggcaugaag caggccaacg gccaguucau cgacaagcuc     2100

gucgaguccg ucaugaagcu cugccucauc auggccaagu acuccaacga cggcgccgcc     2160

cucgccgagc ucgaggagca ggccgccucc gccaacaagc ccaacuuccg cggcacccgc     2220

ugcauccacu ccggcgccau gccccagaac uaccaggacu cccucggcca cgaggucauc     2280

gucaacaacc agugcuccac caacucccuc cagaagcagc uccaggccgu ccuccagugg     2340

aucgccgccu cccaguucaa cguccccaug cucuacuuca ugggcgacaa ggacggccag     2400

cucgagaagc ucccccaggu cuccgccaag gccgccgaga agggcuacuc cgucggcggc     2460

cuccuccagg aggucaugaa guucgccaag gagcgccagc ccgacgaggc cgucggcaag     2520

gucgcccgca agcagcuccu cgacuggcuc cucgccaacc ucuga                     2565


<210>  437
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       AKAP4__Homo_sapiens__AAI26251

<400>  437
augauggccu acagcgacac cacaaugaug uccgaugaca ucgauuggcu gagaucucac       60

aggggcgugu gcaaggucga ccucuauaac cccgaggggc agcaagauca ggaccggaaa      120

guuauuuguu ucguggaugu aucaacucuu aauguggaag acaaggauua caaagacgcu      180

gcaaguagcu ccucugaggg aaaccugaau uuggguucgu uagaagagaa ggaaauaauc      240

gucauuaaag auacggagaa gaaggaccag ucaaaaaccg agggcagcgu gugccuguuu      300

aagcaggccc cuagugaucc aguuuccgug cuaaacuggc uccugucuga ccuucaaaaa      360

uaugcgcugg gguuccagca ugcuuugagc ccguccacau caacuuguaa gcacaaaguc      420

ggagacaccg aaggcgagua ccaucgcgcc aguagcgaaa auugcuauuc uguguacgca      480

gaucagguaa acaucgacua ucucaugaau cgaccccaga accugcgucu ggagaugaca      540

gccgcuaaga auaccaacaa uaaccaaucc ccuucagcac cacccgccaa gccuccaagc      600

acucagagag cuguuauuag ucccgauggu gaguguucua ucgacgaucu cuccuuuuac      660

gugaauaggu uaagcucgcu ggucauacag auggcccaca aagaaaucaa ggagaaacuu      720

gaagggaagu cuaaaugcuu gcaucacucc auuuguccuu caccaggaaa caaggagcgg      780

aucaguccgc gcacacccgc gagcaaaauu gcauccgaaa uggccuacga ggcuguggag      840

cugaccgccg cagaaaugag aggcacgggc gaggaaucua gggaaggggg acaaaagagc      900

uuccuauauu cagaacucag uaauaagucc aaaagcggug acaagcagau gucucagcgg      960

gagucaaaag aguuugcuga uaguaucagc aagggccuga ugguguacgc caaccagguc     1020

gcguccgaca ugaugguuuc ucuuaugaaa acucugaagg ugcacucgag cgggaagccu     1080

auaccagccu ccguaguguu gaaacgcguc cuccugcgac auaccaagga aauuguguca     1140

gauuuaaucg acaguugcau gaaaaaccug cacaauauua caggaguucu caugacugau     1200

ucugacuucg ugagcgcagu caagagaaac cuuuuuaauc aauggaaaca gaacgcuacc     1260

gacaucaugg aggccaugcu gaagagguug guguccgcuc uaaucggcga agagaaggaa     1320

acaaaaucac agagccuguc uuaugccucc cucaaggcag guagucauga ucccaaaugu     1380

cggaaucaga gccuggaguu cucuaccaug aaggccgaga ugaaagaacg ugacaagggg     1440

aagaugaaau ccgauccuug caagucacuu acgagugcug agaaaguagg agaacacauu     1500

cugaaggagg gcuugacuau auggaaccaa aaacagggca auagcuguaa gguugcgaca     1560

aaagcaugcu cgaacaagga cgagaagggg gagaaaauca augccuccac cgauucucuc     1620

gcuaaggacc ugauugugag cgccuuaaaa cugauccagu accaccuaac ucagcaaaca     1680

aagggaaaag auaccugcga ggaagacugu ccagguucaa cgaugggcua uauggcacag     1740

aguacccagu acgagaagug cgggggaggc caguccgcca aggcucucuc ugucaaacaa     1800

cuggaaagcc aucgcgcccc cgguccgucc acaugucaga aggagaacca gcaccuugau     1860

ucacagaaaa uggacaugag caauauagug uugaugcuga uucaaaagcu ccugaacgag     1920

aauccuuuua aaugcgaaga ucccugugag ggggaaaaca agugcaguga gccaagagca     1980

ucuaaggcgg cuuccaugag caauaggucg gacaaagccg aggaacagug ucaggagcau     2040

caagaacuug auugcacuuc aggcaugaag caggcaaacg gacaguucau cgacaaacug     2100

gucgagucug ugaugaaguu gugucucauc auggccaaau auaguaacga cggcgcugcc     2160

cuggcagaau uagaggaaca ggcugccucc gcgaauaagc cuaacuuucg ggggacccga     2220

ugcauucaca gcggagccau gccccaaaau uaccaggauu cucuggguca ugagguuauc     2280

gugaacaauc aguguagcac aaacucccua cagaagcaac uccaggcugu acugcagugg     2340

auugcagccu cacaguucaa ugucccaaug cuuuacuuua ugggcgacaa agaugggcaa     2400

uuggagaagc ugccccaggu gagugcuaaa gccgcagaaa agggauauag cguuggcggu     2460

cuccugcagg aggugaugaa auucgcgaag gaacgccaac cugacgaggc cgucgggaaa     2520

guggcuagaa agcaguuacu ggauuggcuu uuggccaacc ucuga                     2565


<210>  438
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       AKAP4__Homo_sapiens__AAI26251

<400>  438
augauggccu acagcgacac caccaugaug agcgacgaca ucgacuggcu gagaagccac       60

agaggcgugu gcaaggugga ccuguacaac cccgagggcc agcaggacca ggacagaaag      120

gugaucugcu ucguggacgu gagcacccug aacguggagg acaaggacua caaggacgcc      180

gccagcagca gcagcgaggg caaccugaac cugggcagcc uggaggagaa ggagaucauc      240

gugaucaagg acaccgagaa gaaggaccag agcaagaccg agggcagcgu gugccuguuc      300

aagcaggccc ccagcgaccc cgugagcgug cugaacuggc ugcugagcga ccugcagaag      360

uacgcccugg gcuuccagca cgcccugagc cccagcacca gcaccugcaa gcacaaggug      420

ggcgacaccg agggcgagua ccacagagcc agcagcgaga acugcuacag cguguacgcc      480

gaccagguga acaucgacua ccugaugaac agaccccaga accugagacu ggagaugacc      540

gccgccaaga acaccaacaa caaccagagc cccagcgccc cccccgccaa gccccccagc      600

acccagagag ccgugaucag ccccgacggc gagugcagca ucgacgaccu gagcuucuac      660

gugaacagac ugagcagccu ggugauccag auggcccaca aggagaucaa ggagaagcug      720

gagggcaaga gcaagugccu gcaccacagc aucugcccca gccccggcaa caaggagaga      780

aucagcccca gaacccccgc cagcaagauc gccagcgaga uggccuacga ggccguggag      840

cugaccgccg ccgagaugag aggcaccggc gaggagagca gagagggcgg ccagaagagc      900

uuccuguaca gcgagcugag caacaagagc aagagcggcg acaagcagau gagccagaga      960

gagagcaagg aguucgccga cagcaucagc aagggccuga ugguguacgc caaccaggug     1020

gccagcgaca ugauggugag ccugaugaag acccugaagg ugcacagcag cggcaagccc     1080

auccccgcca gcguggugcu gaagagagug cugcugagac acaccaagga gaucgugagc     1140

gaccugaucg acagcugcau gaagaaccug cacaacauca ccggcgugcu gaugaccgac     1200

agcgacuucg ugagcgccgu gaagagaaac cuguucaacc aguggaagca gaacgccacc     1260

gacaucaugg aggccaugcu gaagagacug gugagcgccc ugaucggcga ggagaaggag     1320

accaagagcc agagccugag cuacgccagc cugaaggccg gcagccacga ccccaagugc     1380

agaaaccaga gccuggaguu cagcaccaug aaggccgaga ugaaggagag agacaagggc     1440

aagaugaaga gcgaccccug caagagccug accagcgccg agaagguggg cgagcacauc     1500

cugaaggagg gccugaccau cuggaaccag aagcagggca acagcugcaa gguggccacc     1560

aaggccugca gcaacaagga cgagaagggc gagaagauca acgccagcac cgacagccug     1620

gccaaggacc ugaucgugag cgcccugaag cugauccagu accaccugac ccagcagacc     1680

aagggcaagg acaccugcga ggaggacugc cccggcagca ccaugggcua cauggcccag     1740

agcacccagu acgagaagug cggcggcggc cagagcgcca aggcccugag cgugaagcag     1800

cuggagagcc acagagcccc cggccccagc accugccaga aggagaacca gcaccuggac     1860

agccagaaga uggacaugag caacaucgug cugaugcuga uccagaagcu gcugaacgag     1920

aaccccuuca agugcgagga ccccugcgag ggcgagaaca agugcagcga gcccagagcc     1980

agcaaggccg ccagcaugag caacagaagc gacaaggccg aggagcagug ccaggagcac     2040

caggagcugg acugcaccag cggcaugaag caggccaacg gccaguucau cgacaagcug     2100

guggagagcg ugaugaagcu gugccugauc auggccaagu acagcaacga cggcgccgcc     2160

cuggccgagc uggaggagca ggccgccagc gccaacaagc ccaacuucag aggcaccaga     2220

ugcauccaca gcggcgccau gccccagaac uaccaggaca gccugggcca cgaggugauc     2280

gugaacaacc agugcagcac caacagccug cagaagcagc ugcaggccgu gcugcagugg     2340

aucgccgcca gccaguucaa cgugcccaug cuguacuuca ugggcgacaa ggacggccag     2400

cuggagaagc ugccccaggu gagcgccaag gccgccgaga agggcuacag cgugggcggc     2460

cugcugcagg aggugaugaa guucgccaag gagagacagc ccgacgaggc cgugggcaag     2520

guggccagaa agcagcugcu ggacuggcug cuggccaacc uguga                     2565


<210>  439
<211>  2565
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       AKAP4__Homo_sapiens__AAI26251

<400>  439
augauggccu acagcgacac cacaaugaug uccgaugaca ucgauuggcu gagaucucac       60

cggggcgugu gcaaggucga ccucuauaac cccgaggggc agcaagauca ggaccgcaaa      120

guuauuuguu ucguggaugu gagcacgcug aaugucgaag acaaggauua caaagacgcu      180

gccuccucua gcuccgaggg aaaccuuaau cugggcucuc ucgaagagaa ggaaaucauu      240

gugaucaaag auaccgagaa gaaggaccag agcaaaacag agggguccgu uugccuguuu      300

aagcaggcgc cuagcgaucc ggugucuguc cuuaacuggc ugcucuccga ccugcaaaaa      360

uaugcucugg gauuccagca ugcccucagc cccucuaccu ccacauguaa gcacaaagug      420

ggcgacaccg aaggggagua ccauagagcc agcucugaaa auugcuauuc cguuuacgcu      480

gaucagguga acauugacua ucugaugaau cggccucaga accuucgccu ggagaugaca      540

gccgcuaaga auaccaacaa uaaccaaagc cccuccgccc cucccgcgaa gccuccgucu      600

acgcagagag ccgucaucag ccccgaugga gaguguucca ucgacgaucu cagcuuuuac      660

gugaaucggc ugucuucccu ugugauucag auggcucaca aagaaaucaa ggagaaacug      720

gaaggcaaga gcaaaugccu ccaucacucu auuuguccua gccccggcaa caaggagcgc      780

aucuccccua gaacccccgc cucuaaaauu gcuagcgaaa uggccuacga ggcggucgag      840

cugacagccg cugaaaugcg ggggaccgga gaggaauccc gcgagggcgg gcagaagucu      900

uuccuguauu cugaacucuc caauaagagc aaaucuggag acaagcaaau gucccagaga      960

gagagcaaag aguuugccga uuccaucucu aagggccuga ugguuuacgc uaaccaggug     1020

gccagcgaca ugaugguguc ccuuaugaaa acacugaagg uccacucuag cgggaagccg     1080

auuccugccu ccgugguucu caaacgggug cugcuucgcc auaccaagga aaucgucagc     1140

gaucugaucg acucuugcau gaaaaaccuc cacaauauua cgggagugcu gaugacagau     1200

uccgacuucg uuagcgcugu gaagagaaac cuguuuaauc aauggaaaca gaacgcgacc     1260

gacaucaugg aggccaugcu caagcggcug gucucugcuc uuauuggcga agagaaggaa     1320

acaaaauccc agagccuguc uuaugccagc cucaaggccg gcucccauga ucccaaaugu     1380

cgcaaucaga gccuggaguu cucuaccaug aaggcugaga ugaaagaaag agacaagggg     1440

aagaugaaau ccgauccuug caagagccuu accuccgccg agaaaguggg agaacacauc     1500

cugaaggagg gccucacaau uuggaaccaa aaacagggga auagcuguaa ggucgcgacg     1560

aaggcuugca gcaacaaaga cgagaaggga gagaaaauca augccuccac cgauucucug     1620

gccaaggacc ugaucgugag cgcucucaaa cugauucagu accaccuuac acagcaaacc     1680

aagggcaaag auacaugcga ggaagacugu cccgggucca ccaugggaua uauggcccag     1740

ucuacgcagu acgagaagug cggcggcggg cagagcgcua aggcccuguc cguuaaacaa     1800

cucgaaagcc aucgggcgcc cggaccuucu acaugucaga aggagaacca gcaccuggau     1860

ucccagaaaa uggacaugag caauaucgug cugaugcuua uucaaaagcu ccugaacgag     1920

aauccguuua aaugcgaaga ucccugugag ggcgaaaaca agugcucuga gccuagagcc     1980

uccaaggcug ccagcauguc uaaucgcucc gacaaagcug aagaacagug ucaggagcau     2040

caagaacugg auugcaccag cgggaugaag caggccaacg gacaguucau cgacaaacuc     2100

gucgaguccg ugaugaagcu gugucuuauu auggcgaaau auagcaacga cggcgccgcu     2160

cuggccgaac ucgaggaaca ggcugccucu gccaauaagc ccaacuuucg ggggaccaga     2220

ugcauccaca gcggcgcuau gccucaaaau uaccaggauu cccugggaca ugagguuauc     2280

gugaacaauc aguguucuac aaacagccug cagaagcaac uucaggcggu ccuccagugg     2340

auugccgcuu cccaguucaa ugugcccaug cuguacuuua ugggcgacaa agaugggcaa     2400

cuggagaagc ucccucaggu gucugccaaa gccgcugaaa agggauauag cguuggcggg     2460

cugcuucagg aggucaugaa auucgccaag gaacgccaac cggacgaggc ggugggaaaa     2520

guggcucgga agcagcugcu cgauuggcug cuggccaacc uuuga                     2565


<210>  440
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__B4DSX0

<400>  440

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Trp Arg Ser Arg Ala Ser Ser Ser Pro 
    370                 375                 380                 


Thr Ser Thr Cys Ala Ala Ser Ser Pro Ala Arg Pro Met Leu Trp Gly 
385                 390                 395                 400 


Pro Gly Ser Arg Pro Arg Trp Arg Arg Ser Gly Ala Ser Pro Leu Arg 
                405                 410                 415     






<210>  441
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  441
augguggacu accacgcggc gaaccagucg uaccaguacg gccccagcag cgcgggcaau       60

ggcgcuggcg gcgggggcag caugggcgac uacauggccc aggaggacga cugggaccgg      120

gaccugcugc uggacccggc cugggagaag cagcagcgca agaccuucac ggcauggugc      180

aacucccacc ugcggaaggc aggcacacag aucgagaaca uugaugagga cuuccgagac      240

gggcucaagc ucaugcugcu ccuggagguc auaucagggg agcgguuacc uaagccggag      300

cgggggaaga ugagagugca caaaaucaac aaugugaaca aagcgcugga cuuuauugcc      360

agcaaaggcg ucaagcuggu cuccaucggg gcagaagaga uuguggacgg caacgcaaag      420

augacccugg gaaugaucug gaccaucauc cuuagguucg ccauccagga caucuccgug      480

gaagagaccu cggccaagga agggcuccuu cucuggugcc agagaaagac agccccguau      540

aagaacguca augugcagaa cuuccacauc agcuggaagg auggucuugc cuucaaugcc      600

cugauccacc ggcacagacc agagcugauu gaguaugaca agcugaggaa ggacgacccu      660

gucaccaacc ugaacaaugc cuucgaagug gcugagaaau accucgacau ccccaagaug      720

cuggaugcag aggacaucgu gaacacggcc cggcccgacg agaaggccau aaugaccuau      780

guguccagcu ucuaccaugc cuuuucagga gcgcagaagg cugaaacugc cgccaaccgg      840

aucuguaagg ugcuggcugu caaccaagag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accuccugga guggauccgg cgcaccaucc ccuggcugga ggaccgugug      960

ccccaaaaga cuauccagga gaugcagcag aagcuggagg acuuccgcga cuaccggcgu     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcugg agaucaacuu caacacgcug     1080

cagaccaagc ugcgccucag caaccggccc gccuucaugc ccuccuggag gagcagagca     1140

agcagcaguc caacgagcac cugcgccgcc aguucgccag ccaggccaau guuguggggc     1200

ccuggaucca gaccaagaug gaggagaucg ggcgcaucuc cauugagaug a              1251


<210>  442
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  442
augguggacu accacgccgc caaccagucc uaccaguacg gccccuccag cgcggggaac       60

ggcgccgggg gcgggggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccugcucc uggacccggc cugggagaag cagcagcgga agaccuucac cgccuggugc      180

aacagccacc uccgcaaggc ggggacccag aucgagaaca ucgacgagga cuuccgggac      240

ggccugaagc ugaugcugcu ccuggagguc aucuccgggg agcgccugcc caagcccgag      300

cggggcaaga ugcgcgugca caagaucaac aacgugaaca aggcccucga cuucaucgcc      360

agcaaggggg ucaagcuggu guccaucggc gccgaggaga ucguggacgg caacgcgaag      420

augacccugg ggaugaucug gaccaucauc cuccgguucg ccauccagga caucagcguc      480

gaggagaccu ccgccaagga gggccugcug cucuggugcc agcgcaagac ggcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acgggcuggc cuucaacgcg      600

cugauccacc ggcaccgccc ggagcucauc gaguacgaca agcugcggaa ggacgacccc      660

gucaccaacc ugaacaacgc cuucgaggug gccgagaagu accucgacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc cgccccgacg agaaggcgau caugaccuac      780

gucuccagcu ucuaccacgc cuucuccggc gcccagaagg ccgagacggc cgcgaaccgg      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ucauggagga cuacgagaag      900

cuggccagcg accugcucga guggauccgc cggaccaucc cguggcugga ggaccgcguc      960

ccccagaaga ccauccagga gaugcagcag aagcuggagg acuuccggga cuaccgccgg     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcucg agaucaacuu caacacccug     1080

cagacgaagc ugcgccucuc caaccggccc gccuucaugc ccagcuggcg cucccgcgcc     1140

agcuccagcc ccaccagcac gugcgcggcc uccagccccg cccggccgau gcuguggggc     1200

cccggguccc gcccccggug gcgccggagc ggcgccagcc cccugcgcug a              1251


<210>  443
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  443
auggucgacu accacgccgc caaccagucc uaccaguacg gccccuccuc cgccggcaac       60

ggcgccggcg gcggcggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccuccucc ucgaccccgc cugggagaag cagcagcgca agaccuucac cgccuggugc      180

aacucccacc uccgcaaggc cggcacccag aucgagaaca ucgacgagga cuuccgcgac      240

ggccucaagc ucaugcuccu ccucgagguc aucuccggcg agcgccuccc caagcccgag      300

cgcggcaaga ugcgcgucca caagaucaac aacgucaaca aggcccucga cuucaucgcc      360

uccaagggcg ucaagcucgu cuccaucggc gccgaggaga ucgucgacgg caacgccaag      420

augacccucg gcaugaucug gaccaucauc cuccgcuucg ccauccagga caucuccguc      480

gaggagaccu ccgccaagga gggccuccuc cucuggugcc agcgcaagac cgcccccuac      540

aagaacguca acguccagaa cuuccacauc uccuggaagg acggccucgc cuucaacgcc      600

cucauccacc gccaccgccc cgagcucauc gaguacgaca agcuccgcaa ggacgacccc      660

gucaccaacc ucaacaacgc cuucgagguc gccgagaagu accucgacau ccccaagaug      720

cucgacgccg aggacaucgu caacaccgcc cgccccgacg agaaggccau caugaccuac      780

gucuccuccu ucuaccacgc cuucuccggc gcccagaagg ccgagaccgc cgccaaccgc      840

aucugcaagg uccucgccgu caaccaggag aacgagcacc ucauggagga cuacgagaag      900

cucgccuccg accuccucga guggauccgc cgcaccaucc ccuggcucga ggaccgcguc      960

ccccagaaga ccauccagga gaugcagcag aagcucgagg acuuccgcga cuaccgccgc     1020

guccacaagc cccccaaggu ccaggagaag ugccagcucg agaucaacuu caacacccuc     1080

cagaccaagc uccgccucuc caaccgcccc gccuucaugc ccuccuggcg cucccgcgcc     1140

uccuccuccc ccaccuccac cugcgccgcc uccucccccg cccgccccau gcucuggggc     1200

cccggcuccc gcccccgcug gcgccgcucc ggcgccuccc cccuccgcug a              1251


<210>  444
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  444
augguggacu accacgccgc uaaccagagc uaucaauacg gccccuccuc ugcagggaau       60

ggagccggug gcgggggauc aaugggcgau uauauggcgc aggaggacga uugggacaga      120

gaucugcucc uugacccugc uugggaaaag cagcagagga aaaccuucac agccuggugc      180

aacagucauc ugcggaaggc agguacucaa aucgagaaua uugaugaaga cuuucgcgau      240

ggguugaaau uaaugcugcu acucgagguc auaagcggag aacgacugcc aaagccggag      300

cguggcaaaa ugagaguuca caagaucaac aaugugaaca aggcccuuga cuucauugcu      360

uccaaaggcg uaaagcuggu gucuaucggg gcagaggaaa uugucgaugg aaaugccaaa      420

augacguugg guaugaucug gaccauaauc cucagguuug cuauucagga caucucggug      480

gaggaaacau cagccaagga gggccugcug cucugguguc agcggaaaac ugcgcccuac      540

aagaacguua augugcagaa cuuccauauu agcuggaagg auggguuagc auuuaaugcc      600

cugauccacc gccauagacc ugagcuuaua gaauaugaca aauugaggaa ggacgaucca      660

gucaccaacc ugaauaacgc uuucgaggug gccgaaaaau accuagacau ucccaagaug      720

cucgaugcag aggacaucgu aaauacagcu cggccugaug aaaaagccau uaugaccuau      780

guuaguuccu uuuaccacgc guucucugga gcccaaaagg cagagacugc ugccaaccgc      840

aucugcaaag ugcuggcugu caaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg auuugcucga guggauccga agaacaauuc cauggcugga agacagggug      960

ccccagaaga ccauacagga gaugcaacag aaauuagagg auuuucggga cuaucgucgc     1020

gugcauaagc cuccaaaagu ccaggaaaag ugucaacugg agaucaacuu caauacgcuc     1080

cagacuaaac uuagacuguc caacaggccg gcauuuaugc ccucauggcg gagucgagcc     1140

ucuagcuccc cuaccucaac augcgcugcg agcaguccag cacgccccau guuguggggc     1200

ccugguucua gaccaaggug gcggcgcucc ggggccagcc cccuaagaug a              1251


<210>  445
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  445
augguggacu accacgccgc caaccagagc uaccaguacg gccccagcag cgccggcaac       60

ggcgccggcg gcggcggcag caugggcgac uacauggccc aggaggacga cugggacaga      120

gaccugcugc uggaccccgc cugggagaag cagcagagaa agaccuucac cgccuggugc      180

aacagccacc ugagaaaggc cggcacccag aucgagaaca ucgacgagga cuucagagac      240

ggccugaagc ugaugcugcu gcuggaggug aucagcggcg agagacugcc caagcccgag      300

agaggcaaga ugagagugca caagaucaac aacgugaaca aggcccugga cuucaucgcc      360

agcaagggcg ugaagcuggu gagcaucggc gccgaggaga ucguggacgg caacgccaag      420

augacccugg gcaugaucug gaccaucauc cugagauucg ccauccagga caucagcgug      480

gaggagacca gcgccaagga gggccugcug cuguggugcc agagaaagac cgcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acggccuggc cuucaacgcc      600

cugauccaca gacacagacc cgagcugauc gaguacgaca agcugagaaa ggacgacccc      660

gugaccaacc ugaacaacgc cuucgaggug gccgagaagu accuggacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc agacccgacg agaaggccau caugaccuac      780

gugagcagcu ucuaccacgc cuucagcggc gcccagaagg ccgagaccgc cgccaacaga      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accugcugga guggaucaga agaaccaucc ccuggcugga ggacagagug      960

ccccagaaga ccauccagga gaugcagcag aagcuggagg acuucagaga cuacagaaga     1020

gugcacaagc cccccaaggu gcaggagaag ugccagcugg agaucaacuu caacacccug     1080

cagaccaagc ugagacugag caacagaccc gccuucaugc ccagcuggag aagcagagcc     1140

agcagcagcc ccaccagcac cugcgccgcc agcagccccg ccagacccau gcuguggggc     1200

cccggcagca gacccagaug gagaagaagc ggcgccagcc cccugagaug a              1251


<210>  446
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       alpha-actinin-_4/m__Homo_sapiens__BAG61782

<400>  446
augguggacu accacgccgc uaaccagagc uaucaauacg gccccuccuc ugccgggaau       60

ggagcgggcg ggggaggcag caugggggau uauauggcuc aggaggacga uugggacaga      120

gaucugcucc uggacccugc cugggaaaag cagcagcgga aaaccuucac agccuggugc      180

aacucccauc uucgcaaggc uggaacgcaa aucgagaaua uugaugaaga cuuuagagau      240

ggccugaaac ucaugcugcu ucuggagguc aucucuggcg aacggcuccc gaagcccgag      300

cgcgggaaaa ugagaguuca caagauuaac aaugugaaca aggcccugga cuucaucgcu      360

agcaaaggag ugaagcuggu cuccauuggc gccgaggaaa ucguggaugg gaaugcgaaa      420

augacccucg gaaugaucug gacaauuauc cugcgguuug ccauucagga caucucuguu      480

gaggaaacca gcgcuaagga gggccuucug cucugguguc agcgcaaaac agccccuuac      540

aagaacguga auguccagaa cuuccauauu uccuggaagg augggcuggc uuuuaaugcc      600

cuuauccaca gacaucggcc cgagcugauu gaauaugaca aacuccgcaa ggacgauccu      660

gugaccaacc ugaauaacgc guucgagguu gccgaaaaau accuggacau ccccaagaug      720

cucgaugcug aggacaucgu gaauacagcc agaccugaug aaaaagcuau uaugaccuau      780

gucagcucuu uuuaccacgc cuucuccgga gcccaaaagg cugagacggc ggccaaccgg      840

aucugcaaag ugcuggcugu gaaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg aucuccugga guggauucgc agaaccaucc cguggcuuga agaccggguc      960

ccccagaaga caauucagga gaugcaacag aaacuggagg auuuucgcga cuauagacgg     1020

guucauaagc cucccaaagu gcaggaaaag ugucaacucg agaucaacuu caauacccug     1080

cagacaaaac ugagacucuc uaaccgcccu gccuuuaugc ccuccuggcg gagcagagcu     1140

ucuuccagcc cgaccuccac gugcgccgcg ucuagcccug cucgccccau gcuguggggc     1200

ccuggcuccc ggcccagaug gcgccggagc ggggccucuc cccuuagaug a              1251


<210>  447
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__B4E337

<400>  447

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Gln Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Ala Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Pro Asp Gly 
                485                 490                 495     


Leu Gln Glu Gly Pro Gly Gln Pro His Ser Pro Ile Pro Pro Leu Cys 
            500                 505                 510         


Ile Tyr Ala Lys His Ser Leu Gln Ser Ser Gly Val Gly Gly Trp Ala 
        515                 520                 525             


Gly Arg Gly Trp Gly Arg Leu Ser Pro Leu Ser Leu Cys Gly Leu Ala 
    530                 535                 540                 


Arg Arg Phe Pro Arg Pro Gly Trp Gly Asp Leu Gly Pro Ala Leu Leu 
545                 550                 555                 560 


Val Trp 
        


<210>  448
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  448
augguggacu accacgcggc gaaccagucg uaccaguacg gccccagcag cgcgggcaau       60

ggcgcuggcg gcgggggcag caugggcgac uacauggccc aggaggacga cugggaccgg      120

gaccugcugc uggacccggc cugggagaag cagcagcgca agaccuucac ggcauggugc      180

aacucccacc ugcggaaggc aggcacacag aucgagaaca uugaugagga cuuccgagac      240

gggcucaagc ucaugcugcu ccuggagguc auaucagggg agcgguuacc uaagccggag      300

cgggggaaga ugagagugca caaaaucaac aaugugaaca aagcgcugga cuuuauugcc      360

agcaaaggcg ucaagcuggu cuccaucggg gcagaagaga uuguggacgg caacgcaaag      420

augacccugg gaaugaucug gaccaucauc cuuagguucg ccauccagga caucuccgug      480

gaagagaccu cggccaagga agggcuccuu cucuggugcc agagaaagac agccccauau      540

aagaacguca augugcagaa cuuccacauc agcuggaagg auggucuugc cuucaaugcc      600

cugauccacc ggcacagacc agagcugauu gaguaugaca agcugaggaa ggacgacccu      660

gucaccaacc ugaacaaugc cuucgaagug gcugagaaau accucgacau ccccaagaug      720

cuggaugcag aggacaucgu gaacacggcc cggcccgacg agaaggccau aaugaccuau      780

guguccagcu ucuaccaugc cuuuucagga gcgcagaagg cugaaacugc cgccaaccgg      840

aucuguaagg ugcuggcugu caaccaagag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accuccugga guggauccag cgcaccaucc ccuggcugga ggaccgugug      960

ccccaaaagg cuauccagga gaugcagcag aagcuggagg acuuccgcga cuaccggcgu     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcugg agaucaacuu caacacgcug     1080

cagaccaagc ugcgccucag caaccggccc gccuucaugc ccuccgaggg caagaugguc     1140

ucggacauca acaauggcug gcagcacuug gagcaggcug agaagggcua cgaggagugg     1200

cugcugaaug agauccgcag gcuggagcgg cucgaccacc uggcagagaa guuccggcag     1260

aaggccucca uccacgaggc cuggacugac gggaaggaag ccaugcugaa gcaccgggac     1320

uacgagacgg ccacacuauc ggacaucaaa gcccucauuc gcaagcacga ggccuucgag     1380

agcgaccugg cugcgcacca ggaccgcgug gagcagaucg ccgccauugc ccaggagcuc     1440

aacgagcugg auuacuacga cucccacaau gucaacaccc ccgacggccu ccaggagggg     1500

ccugggcagc cccacagucc cauuccucca cucuguaucu augcaaagca cucucugcag     1560

uccuccgggg ugggugggug ggcagggagg ggcuggggca ggcucucucc ucucucucuu     1620

uguggguugg ccaggagguu cccccgacca gguuggggag acuuggggcc agcgcuucug     1680

gucugguaa                                                             1689


<210>  449
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  449
augguggacu accacgccgc caaccagagc uaccaguacg gccccuccag cgcggggaac       60

ggcgccgggg gcgggggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccugcucc uggacccggc cugggagaag cagcagcgga agaccuucac cgccuggugc      180

aacagccacc uccgcaaggc ggggacgcag aucgagaaca ucgacgagga cuuccgggac      240

ggccugaagc ugaugcugcu ccuggagguc aucuccgggg agcgccugcc caagcccgag      300

cggggcaaga ugcgcgugca caagaucaac aacgugaaca aggcccucga cuucaucgcc      360

agcaaggggg ucaagcuggu guccaucggc gccgaggaga ucguggacgg caacgcgaag      420

augacccugg ggaugaucug gaccaucauc cuccgguucg ccauccagga caucagcguc      480

gaggagaccu ccgccaagga gggccugcug cucuggugcc agcgcaagac ggcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acgggcuggc cuucaacgcg      600

cugauccacc ggcaccgccc ggagcucauc gaguacgaca agcugcggaa ggacgacccc      660

gucaccaacc ugaacaacgc cuucgaggug gccgagaagu accucgacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc cgccccgacg agaaggcgau caugaccuac      780

gucuccagcu ucuaccacgc cuucuccggc gcccagaagg ccgagacggc cgcgaaccgg      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ucauggagga cuacgagaag      900

cuggccagcg accugcucga guggauccag cgcaccaucc cguggcugga ggaccggguc      960

ccccagaagg ccauccagga gaugcagcag aagcuggagg acuuccgcga cuaccggcgc     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcucg agaucaacuu caacacccug     1080

cagaccaagc ugcggcucuc caaccgcccc gccuucaugc ccagcgaggg caagaugguc     1140

uccgacauca acaacgggug gcagcaccug gagcaggcgg agaagggcua cgaggagugg     1200

cugcucaacg agauccggcg ccuggagcgc cuggaccacc ucgccgagaa guuccggcag     1260

aaggccagca uccacgaggc cuggacggac gggaaggagg cgaugcugaa gcaccgcgac     1320

uacgagaccg ccacccuguc cgacaucaag gcccucaucc ggaagcacga ggccuucgag     1380

agcgaccugg ccgcgcacca ggaccgcgug gagcagaucg ccgccaucgc ccaggagcug     1440

aacgagcucg acuacuacga cagccacaac gugaacaccc ccgacggccu gcaggagggg     1500

cccggccagc cgcacucccc caucccgccc cugugcaucu acgccaagca cagccuccag     1560

uccagcggcg ucgggggcug ggcggggcgg ggcugggggc gccugagccc ccugucccug     1620

ugcggccucg cccggcgcuu cccccggccc ggcuggggcg accuggggcc cgcccugcuc     1680

gugugguga                                                             1689


<210>  450
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  450
auggucgacu accacgccgc caaccagucc uaccaguacg gccccuccuc cgccggcaac       60

ggcgccggcg gcggcggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccuccucc ucgaccccgc cugggagaag cagcagcgca agaccuucac cgccuggugc      180

aacucccacc uccgcaaggc cggcacccag aucgagaaca ucgacgagga cuuccgcgac      240

ggccucaagc ucaugcuccu ccucgagguc aucuccggcg agcgccuccc caagcccgag      300

cgcggcaaga ugcgcgucca caagaucaac aacgucaaca aggcccucga cuucaucgcc      360

uccaagggcg ucaagcucgu cuccaucggc gccgaggaga ucgucgacgg caacgccaag      420

augacccucg gcaugaucug gaccaucauc cuccgcuucg ccauccagga caucuccguc      480

gaggagaccu ccgccaagga gggccuccuc cucuggugcc agcgcaagac cgcccccuac      540

aagaacguca acguccagaa cuuccacauc uccuggaagg acggccucgc cuucaacgcc      600

cucauccacc gccaccgccc cgagcucauc gaguacgaca agcuccgcaa ggacgacccc      660

gucaccaacc ucaacaacgc cuucgagguc gccgagaagu accucgacau ccccaagaug      720

cucgacgccg aggacaucgu caacaccgcc cgccccgacg agaaggccau caugaccuac      780

gucuccuccu ucuaccacgc cuucuccggc gcccagaagg ccgagaccgc cgccaaccgc      840

aucugcaagg uccucgccgu caaccaggag aacgagcacc ucauggagga cuacgagaag      900

cucgccuccg accuccucga guggauccag cgcaccaucc ccuggcucga ggaccgcguc      960

ccccagaagg ccauccagga gaugcagcag aagcucgagg acuuccgcga cuaccgccgc     1020

guccacaagc cccccaaggu ccaggagaag ugccagcucg agaucaacuu caacacccuc     1080

cagaccaagc uccgccucuc caaccgcccc gccuucaugc ccuccgaggg caagaugguc     1140

uccgacauca acaacggcug gcagcaccuc gagcaggccg agaagggcua cgaggagugg     1200

cuccucaacg agauccgccg ccucgagcgc cucgaccacc ucgccgagaa guuccgccag     1260

aaggccucca uccacgaggc cuggaccgac ggcaaggagg ccaugcucaa gcaccgcgac     1320

uacgagaccg ccacccucuc cgacaucaag gcccucaucc gcaagcacga ggccuucgag     1380

uccgaccucg ccgcccacca ggaccgcguc gagcagaucg ccgccaucgc ccaggagcuc     1440

aacgagcucg acuacuacga cucccacaac gucaacaccc ccgacggccu ccaggagggc     1500

cccggccagc cccacucccc cauccccccc cucugcaucu acgccaagca cucccuccag     1560

uccuccggcg ucggcggcug ggccggccgc ggcuggggcc gccucucccc ccucucccuc     1620

ugcggccucg cccgccgcuu cccccgcccc ggcuggggcg accucggccc cgcccuccuc     1680

gucugguga                                                             1689


<210>  451
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  451
augguggacu accacgcugc uaaccagagc uaucaauacg gccccuccuc ugcagggaau       60

ggagccggug gcgggggauc aaugggcgau uauauggcgc aggaggacga uugggacaga      120

gaucugcucc uugacccugc uugggaaaag cagcagagga aaaccuucac agccuggugc      180

aacagucauc ugcggaaggc agguacucaa aucgagaaua uugaugaaga cuuucgcgau      240

ggguugaaau uaaugcugcu acucgagguc auaagcggag aacgacugcc aaagccggag      300

cguggcaaaa ugagaguuca caagaucaac aaugugaaca aggcccuuga cuucauugcu      360

uccaaaggcg uaaagcuggu gucuaucggg gcagaggaaa uugucgaugg aaaugccaaa      420

augacguugg guaugaucug gaccauaauc cucagguuug cuauucagga caucucggug      480

gaggaaacau cagccaagga gggccugcug cucugguguc agcggaaaac ugcgcccuac      540

aagaacguua augugcagaa cuuccauauu agcuggaagg auggguuagc auuuaaugcc      600

cugauccacc gccauagacc ugagcuuaua gaauaugaca aauugaggaa ggacgaucca      660

gucaccaacc ugaauaacgc uuucgaggug gccgaaaaau accuagacau ucccaagaug      720

cucgaugcag aggacaucgu aaauacagcu cggccugaug aaaaagccau uaugaccuau      780

guuaguuccu uuuaccacgc guucucugga gcccaaaagg cagagacugc ugccaaccgc      840

aucugcaaag ugcuggcugu caaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg auuugcucga guggauccag cgaacaauuc cauggcugga agacagagug      960

ccccagaagg caauacaaga gaugcagcag aaauuagagg auuuuaggga cuaucggcgu     1020

gugcauaagc cuccaaaagu ccaagaaaag ugucagcugg agaucaacuu caauacccuc     1080

cagacgaaac uucgccuguc caacagaccg gccuuuaugc ccucagaagg caagaugguu     1140

agugauauua auaacgguug gcagcacuug gagcaagcug aaaaggggua cgaggagugg     1200

cuacugaaug aaaucaggcg gcucgagcga cuggaccauc uugcggaaaa auuccgccag     1260

aaggcaagca uacacgaggc cuggacugac ggaaaagagg cuaugcugaa gcacagagau     1320

uaugaaaccg ccacauuguc ugacauuaaa gcacucauca ggaagcauga ggccuuugaa     1380

uccgaucugg cugcccacca ggaccgggug gagcagaucg cagcgauugc ucaagaauua     1440

aacgagcugg auuacuauga cucacauaau guaaacacuc cugauggccu acaggagggc     1500

ccagggcagc cccacagccc uaucccaccc cucugcauuu acgccaagca uagucugcag     1560

ucuuccggag uggguggcug ggcagggcgc ggauggggca gacuuagccc guugucgcug     1620

uguggucucg ccaggcguuu cccucggccc ggguggggcg accugggacc agcccuucug     1680

gucugguga                                                             1689


<210>  452
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  452
augguggacu accacgccgc caaccagagc uaccaguacg gccccagcag cgccggcaac       60

ggcgccggcg gcggcggcag caugggcgac uacauggccc aggaggacga cugggacaga      120

gaccugcugc uggaccccgc cugggagaag cagcagagaa agaccuucac cgccuggugc      180

aacagccacc ugagaaaggc cggcacccag aucgagaaca ucgacgagga cuucagagac      240

ggccugaagc ugaugcugcu gcuggaggug aucagcggcg agagacugcc caagcccgag      300

agaggcaaga ugagagugca caagaucaac aacgugaaca aggcccugga cuucaucgcc      360

agcaagggcg ugaagcuggu gagcaucggc gccgaggaga ucguggacgg caacgccaag      420

augacccugg gcaugaucug gaccaucauc cugagauucg ccauccagga caucagcgug      480

gaggagacca gcgccaagga gggccugcug cuguggugcc agagaaagac cgcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acggccuggc cuucaacgcc      600

cugauccaca gacacagacc cgagcugauc gaguacgaca agcugagaaa ggacgacccc      660

gugaccaacc ugaacaacgc cuucgaggug gccgagaagu accuggacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc agacccgacg agaaggccau caugaccuac      780

gugagcagcu ucuaccacgc cuucagcggc gcccagaagg ccgagaccgc cgccaacaga      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accugcugga guggauccag agaaccaucc ccuggcugga ggacagagug      960

ccccagaagg ccauccagga gaugcagcag aagcuggagg acuucagaga cuacagaaga     1020

gugcacaagc cccccaaggu gcaggagaag ugccagcugg agaucaacuu caacacccug     1080

cagaccaagc ugagacugag caacagaccc gccuucaugc ccagcgaggg caagauggug     1140

agcgacauca acaacggcug gcagcaccug gagcaggccg agaagggcua cgaggagugg     1200

cugcugaacg agaucagaag acuggagaga cuggaccacc uggccgagaa guucagacag     1260

aaggccagca uccacgaggc cuggaccgac ggcaaggagg ccaugcugaa gcacagagac     1320

uacgagaccg ccacccugag cgacaucaag gcccugauca gaaagcacga ggccuucgag     1380

agcgaccugg ccgcccacca ggacagagug gagcagaucg ccgccaucgc ccaggagcug     1440

aacgagcugg acuacuacga cagccacaac gugaacaccc ccgacggccu gcaggagggc     1500

cccggccagc cccacagccc cauccccccc cugugcaucu acgccaagca cagccugcag     1560

agcagcggcg ugggcggcug ggccggcaga ggcuggggca gacugagccc ccugagccug     1620

ugcggccugg ccagaagauu ccccagaccc ggcuggggcg accugggccc cgcccugcug     1680

gugugguga                                                             1689


<210>  453
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       alpha-actinin-_4/m__Homo_sapiens__BAG65349

<400>  453
augguggacu accacgccgc uaaccagagc uaucaauacg gccccuccuc ugccgggaau       60

ggagcgggcg ggggaggcag caugggggau uauauggcuc aggaggacga uugggacaga      120

gaucugcucc uggacccugc cugggaaaag cagcagcgga aaaccuucac agccuggugc      180

aacucccauc uucgcaaggc uggaacgcaa aucgagaaua uugaugaaga cuuuagagau      240

ggccugaaac ucaugcugcu ucuggagguc aucucuggcg aacggcuccc gaagcccgag      300

cgcgggaaaa ugagaguuca caagauuaac aaugugaaca aggcccugga cuucaucgcu      360

agcaaaggag ugaagcuggu cuccauuggc gccgaggaaa ucguggaugg gaaugcgaaa      420

augacccucg gaaugaucug gacaauuauc cugcgguuug ccauucagga caucucuguu      480

gaggaaacca gcgcuaagga gggccuucug cucugguguc agcgcaaaac agccccuuac      540

aagaacguga auguccagaa cuuccauauu uccuggaagg augggcuggc uuuuaaugcc      600

cuuauccaca gacaucggcc cgagcugauu gaauaugaca aacuccgcaa ggacgauccu      660

gugaccaacc ugaauaacgc guucgagguu gccgaaaaau accuggacau ccccaagaug      720

cucgaugcug aggacaucgu gaauacagcc agaccugaug aaaaagcuau uaugaccuau      780

gucagcucuu uuuaccacgc cuucuccgga gcccaaaagg cugagacggc ggccaaccgg      840

aucugcaaag ugcuggcugu gaaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg aucuccugga guggauucag cgcaccaucc cguggcuuga agacagaguc      960

ccccagaagg ccauucaaga gaugcagcag aaacuggagg auuuucggga cuaucgcaga     1020

guucauaagc cucccaaagu gcaagaaaag ugucagcucg agaucaacuu caauacacug     1080

cagaccaaac ugcggcucuc uaacagaccu gcuuuuaugc ccuccgaagg caagauggug     1140

agcgauauca auaacggcug gcagcaccug gagcaagccg aaaaggggua cgaggagugg     1200

cuucugaaug aaauucgccg gcucgagaga cuggaccauc uugcggaaaa auuccgccag     1260

aaggcuucua uccacgaggc cuggacagac ggaaaagagg ccaugcugaa gcaccgggau     1320

uaugaaaccg cuacgcucuc cgacauuaaa gcccugauca gaaagcauga ggcuuuugaa     1380

agcgaucugg ccgcgcacca ggaccgcguc gagcagauug ccgcuaucgc ccaagaacuc     1440

aacgagcugg auuacuauga cucccauaau gugaacacac cggauggccu ucaggagggg     1500

ccuggacagc cccacucucc uaucccuccc cugugcauuu acgcuaagca uagccuccag     1560

uccagcggcg uugggggaug ggccggccgg ggcuggggga gacugucucc ccugucccuu     1620

uguggacucg cgcgccgguu cccgagaccc ggcuggggag accuggggcc ugcccugcuc     1680

gugugguga                                                             1689


<210>  454
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__O43707

<400>  454

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210>  455
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  455
augguggacu accacgcggc gaaccagucg uaccaguacg gccccagcag cgcgggcaau       60

ggcgcuggcg gcgggggcag caugggcgac uacauggccc aggaggacga cugggaccgg      120

gaccugcugc uggacccggc cugggagaag cagcagcgca agaccuucac ggcauggugc      180

aacucccacc ugcggaaggc aggcacacag aucgagaaca uugaugagga cuuccgagac      240

gggcucaagc ucaugcugcu ccuggagguc auaucagggg agcgguuacc uaagccggag      300

cgggggaaga ugagagugca caaaaucaac aaugugaaca aagcgcugga cuuuauugcc      360

agcaaaggcg ucaagcuggu cuccaucggg gcagaagaga uuguggacgg caacgcaaag      420

augacccugg gaaugaucug gaccaucauc cuuagguucg ccauccagga caucuccgug      480

gaagagaccu cggccaagga agggcuccuu cucuggugcc agagaaagac agccccguau      540

aagaacguca augugcagaa cuuccacauc agcuggaagg auggucuugc cuucaaugcc      600

cugauccacc ggcacagacc agagcugauu gaguaugaca agcugaggaa ggacgacccu      660

gucaccaacc ugaacaaugc cuucgaagug gcugagaaau accucgacau ccccaagaug      720

cuggaugcag aggacaucgu gaacacggcc cggcccgacg agaaggccau aaugaccuau      780

guguccagcu ucuaccaugc cuuuucagga gcgcagaagg cugaaacugc cgccaaccgg      840

aucuguaagg ugcuggcugu caaccaagag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accuccugga guggauccgg cgcaccaucc ccuggcugga ggaccgugug      960

ccccaaaaga cuauccagga gaugcagcag aagcuggagg acuuccgcga cuaccggcgu     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcugg agaucaacuu caacacgcug     1080

cagaccaagc ugcgccucag caaccggccc gccuucaugc ccuccgaggg caagaugguc     1140

ucggacauca acaauggcug gcagcacuug gagcaggcug agaagggcua cgaggagugg     1200

cugcugaaug agauccgcag gcuggagcgg cucgaccacc uggcagagaa guuccggcag     1260

aaggccucca uccacgaggc cuggacugac gggaaggaag ccaugcugaa gcaccgggac     1320

uacgagacgg ccacacuauc ggacaucaaa gcccucauuc gcaagcacga ggccuucgag     1380

agcgaccugg cugcgcacca ggaccgcgug gagcagaucg ccgccauugc ccaggagcuc     1440

aacgagcugg auuacuacga cucccacaau gucaacaccc ggugccagaa gaucugugac     1500

cagugggacg cccucggcuc ucugacacau agucgcaggg aagcccugga gaaaacagag     1560

aagcagcugg aggccaucga ccagcugcac cuggaauacg ccaagcgcgc ggcccccuuc     1620

aacaacugga uggagagcgc cauggaggac cuccaggaca uguucaucgu ccauaccauc     1680

gaggagauug agggccugau cucagcccau gaccaguuca aguccacccu gccggacgcc     1740

gauagggagc gcgaggccau ccuggccauc cacaaggagg cccagaggau cgcugagagc     1800

aaccacauca agcugucggg cagcaacccc uacaccaccg ucaccccgca aaucaucaac     1860

uccaaguggg agaaggugca gcagcuggug ccaaaacggg accaugcccu ccuggaggag     1920

cagagcaagc agcaguccaa cgagcaccug cgccgccagu ucgccagcca ggccaauguu     1980

guggggcccu ggauccagac caagauggag gagaucgggc gcaucuccau ugagaugaac     2040

gggacccugg aggaccagcu gagccaccug aagcaguaug aacgcagcau cguggacuac     2100

aagcccaacc uggaccugcu ggagcagcag caccagcuca uccaggaggc ccucaucuuc     2160

gacaacaagc acaccaacua uaccauggag cacauccgcg ugggcuggga gcagcugcuc     2220

accaccauug cccgcaccau caacgaggug gagaaccaga uccucacccg cgacgccaag     2280

ggcaucagcc aggagcagau gcaggaguuc cgggcguccu ucaaccacuu cgacaaggau     2340

cauggcgggg cgcuggggcc cgaggaguuc aaggccugcc ucaucagccu gggcuacgac     2400

guggagaacg accggcaggg ugaggccgag uucaaccgca ucaugagccu ggucgacccc     2460

aaccauagcg gccuugugac cuuccaagcc uucaucgacu ucaugucgcg ggagaccacc     2520

gacacggaca cggcugacca ggucaucgcu uccuucaagg ucuuagcagg ggacaagaac     2580

uucaucacag cugaggagcu gcggagagag cugccccccg accaggccga guacugcauc     2640

gcccgcaugg cgccauacca gggcccugac gccgugcccg gugcccucga cuacaagucc     2700

uucuccacgg ccuuguaugg cgagagcgac cuguga                               2736


<210>  456
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  456
augguggacu accacgccgc caaccagagc uaccaguacg gccccuccag cgcggggaac       60

ggcgccgggg gcgggggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccugcucc uggacccggc cugggagaag cagcagcgga agaccuucac cgccuggugc      180

aacagccacc uccgcaaggc ggggacgcag aucgagaaca ucgacgagga cuuccgggac      240

ggccucaagc ugaugcugcu ccuggagguc aucuccgggg agcgccugcc caagcccgag      300

cggggcaaga ugcgcgugca caagaucaac aacgugaaca aggcccucga cuucaucgcc      360

agcaaggggg ucaagcuggu guccaucggc gccgaggaga ucguggacgg caacgcgaag      420

augacccugg ggaugaucug gaccaucauc cuccgguucg ccauccagga caucagcguc      480

gaggagaccu ccgccaagga gggccugcug cucuggugcc agcgcaagac ggcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acgggcuggc cuucaacgcg      600

cugauccacc ggcaccgccc ggagcucauc gaguacgaca agcugcggaa ggacgacccc      660

gucaccaacc ugaacaacgc cuucgaggug gccgagaagu accucgacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc cgccccgacg agaaggcgau caugaccuac      780

gucuccagcu ucuaccacgc cuucuccggc gcccagaagg ccgagacggc cgcgaaccgg      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ucauggagga cuacgagaag      900

cuggccagcg accugcucga guggauccgc cggaccaucc cguggcugga ggaccgcguc      960

ccccagaaga ccauccagga gaugcagcag aagcuggagg acuuccggga cuaccgccgg     1020

gugcacaagc cgcccaaggu gcaggagaag ugccagcucg agaucaacuu caacacccug     1080

cagacgaagc ugcgccucuc caaccggccc gccuucaugc ccagcgaggg caagaugguc     1140

uccgacauca acaacgggug gcagcaccug gagcaggccg agaagggcua cgaggagugg     1200

cugcucaacg agauccgccg ccuggagcgg cuggaccacc ucgcggagaa guuccgccag     1260

aaggccagca uccacgaggc cuggaccgac gggaaggagg ccaugcugaa gcaccgggac     1320

uacgagaccg cgacccuguc cgacaucaag gcccucaucc gcaagcacga ggccuucgag     1380

agcgaccugg ccgcccacca ggaccgggug gagcagaucg cggccaucgc ccaggagcug     1440

aacgagcucg acuacuacga cagccacaac gugaacacgc gcugccagaa gaucugcgac     1500

cagugggacg cccugggcuc ccugacccac agccggcgcg aggcccucga gaagaccgag     1560

aagcagcugg aggcgaucga ccagcugcac cuggaguacg ccaagcgggc cgcccccuuc     1620

aacaacugga uggaguccgc cauggaggac cuccaggaca uguucaucgu ccacaccauc     1680

gaggagaucg aggggcugau cagcgcgcac gaccaguuca aguccacgcu gcccgacgcc     1740

gaccgcgagc gggaggccau ccucgccauc cacaaggagg cgcagcgcau cgccgagagc     1800

aaccacauca agcuguccgg cagcaacccg uacaccaccg ugacgcccca gaucaucaac     1860

uccaaguggg agaaggugca gcagcugguc cccaagcggg accacgcccu ccuggaggag     1920

cagagcaagc agcaguccaa cgagcaccuc cgccggcagu ucgccagcca ggccaacgug     1980

gucggccccu ggauccagac caagauggag gagaucgggc gcaucuccau cgagaugaac     2040

ggcacccugg aggaccagcu gagccaccug aagcaguacg agcgguccau cguggacuac     2100

aagccgaacc ucgaccugcu ggagcagcag caccagcuca uccaggaggc gcugaucuuc     2160

gacaacaagc acaccaacua caccauggag cacauccgcg ugggguggga gcagcugcuc     2220

acgaccaucg cccggaccau caacgagguc gagaaccaga uccugacccg cgacgccaag     2280

ggcaucagcc aggagcagau gcaggaguuc cgcgccuccu ucaaccacuu cgacaaggac     2340

cacgggggcg cccugggccc cgaggaguuc aaggcgugcc ucaucagccu gggguacgac     2400

guggagaacg accggcaggg cgaggccgag uucaaccgca ucaugucccu gguggacccc     2460

aaccacagcg ggcucgucac guuccaggcc uucaucgacu ucaugagccg ggagaccacc     2520

gacaccgaca cggccgacca ggugaucgcc uccuucaagg ugcuggcggg cgacaagaac     2580

uucaucaccg ccgaggagcu gcgccgggag cugcccccgg accaggccga guacugcauc     2640

gcccgcaugg cgcccuacca ggggcccgac gccguccccg gcgcccugga cuacaagagc     2700

uucuccaccg cccuguacgg cgagagcgac cucuga                               2736


<210>  457
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  457
auggucgacu accacgccgc caaccagucc uaccaguacg gccccuccuc cgccggcaac       60

ggcgccggcg gcggcggcuc caugggcgac uacauggccc aggaggacga cugggaccgc      120

gaccuccucc ucgaccccgc cugggagaag cagcagcgca agaccuucac cgccuggugc      180

aacucccacc uccgcaaggc cggcacccag aucgagaaca ucgacgagga cuuccgcgac      240

ggccucaagc ucaugcuccu ccucgagguc aucuccggcg agcgccuccc caagcccgag      300

cgcggcaaga ugcgcgucca caagaucaac aacgucaaca aggcccucga cuucaucgcc      360

uccaagggcg ucaagcucgu cuccaucggc gccgaggaga ucgucgacgg caacgccaag      420

augacccucg gcaugaucug gaccaucauc cuccgcuucg ccauccagga caucuccguc      480

gaggagaccu ccgccaagga gggccuccuc cucuggugcc agcgcaagac cgcccccuac      540

aagaacguca acguccagaa cuuccacauc uccuggaagg acggccucgc cuucaacgcc      600

cucauccacc gccaccgccc cgagcucauc gaguacgaca agcuccgcaa ggacgacccc      660

gucaccaacc ucaacaacgc cuucgagguc gccgagaagu accucgacau ccccaagaug      720

cucgacgccg aggacaucgu caacaccgcc cgccccgacg agaaggccau caugaccuac      780

gucuccuccu ucuaccacgc cuucuccggc gcccagaagg ccgagaccgc cgccaaccgc      840

aucugcaagg uccucgccgu caaccaggag aacgagcacc ucauggagga cuacgagaag      900

cucgccuccg accuccucga guggauccgc cgcaccaucc ccuggcucga ggaccgcguc      960

ccccagaaga ccauccagga gaugcagcag aagcucgagg acuuccgcga cuaccgccgc     1020

guccacaagc cccccaaggu ccaggagaag ugccagcucg agaucaacuu caacacccuc     1080

cagaccaagc uccgccucuc caaccgcccc gccuucaugc ccuccgaggg caagaugguc     1140

uccgacauca acaacggcug gcagcaccuc gagcaggccg agaagggcua cgaggagugg     1200

cuccucaacg agauccgccg ccucgagcgc cucgaccacc ucgccgagaa guuccgccag     1260

aaggccucca uccacgaggc cuggaccgac ggcaaggagg ccaugcucaa gcaccgcgac     1320

uacgagaccg ccacccucuc cgacaucaag gcccucaucc gcaagcacga ggccuucgag     1380

uccgaccucg ccgcccacca ggaccgcguc gagcagaucg ccgccaucgc ccaggagcuc     1440

aacgagcucg acuacuacga cucccacaac gucaacaccc gcugccagaa gaucugcgac     1500

cagugggacg cccucggcuc ccucacccac ucccgccgcg aggcccucga gaagaccgag     1560

aagcagcucg aggccaucga ccagcuccac cucgaguacg ccaagcgcgc cgcccccuuc     1620

aacaacugga uggaguccgc cauggaggac cuccaggaca uguucaucgu ccacaccauc     1680

gaggagaucg agggccucau cuccgcccac gaccaguuca aguccacccu ccccgacgcc     1740

gaccgcgagc gcgaggccau ccucgccauc cacaaggagg cccagcgcau cgccgagucc     1800

aaccacauca agcucuccgg cuccaacccc uacaccaccg ucacccccca gaucaucaac     1860

uccaaguggg agaaggucca gcagcucguc cccaagcgcg accacgcccu ccucgaggag     1920

caguccaagc agcaguccaa cgagcaccuc cgccgccagu ucgccuccca ggccaacguc     1980

gucggccccu ggauccagac caagauggag gagaucggcc gcaucuccau cgagaugaac     2040

ggcacccucg aggaccagcu cucccaccuc aagcaguacg agcgcuccau cgucgacuac     2100

aagcccaacc ucgaccuccu cgagcagcag caccagcuca uccaggaggc ccucaucuuc     2160

gacaacaagc acaccaacua caccauggag cacauccgcg ucggcuggga gcagcuccuc     2220

accaccaucg cccgcaccau caacgagguc gagaaccaga uccucacccg cgacgccaag     2280

ggcaucuccc aggagcagau gcaggaguuc cgcgccuccu ucaaccacuu cgacaaggac     2340

cacggcggcg cccucggccc cgaggaguuc aaggccugcc ucaucucccu cggcuacgac     2400

gucgagaacg accgccaggg cgaggccgag uucaaccgca ucaugucccu cgucgacccc     2460

aaccacuccg gccucgucac cuuccaggcc uucaucgacu ucaugucccg cgagaccacc     2520

gacaccgaca ccgccgacca ggucaucgcc uccuucaagg uccucgccgg cgacaagaac     2580

uucaucaccg ccgaggagcu ccgccgcgag cucccccccg accaggccga guacugcauc     2640

gcccgcaugg cccccuacca gggccccgac gccguccccg gcgcccucga cuacaagucc     2700

uucuccaccg cccucuacgg cgaguccgac cucuga                               2736


<210>  458
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  458
augguggacu accacgccgc uaaccagagc uaucaauacg gccccuccuc ugcagggaau       60

ggagccggug gcgggggauc aaugggcgau uauauggcgc aggaggacga uugggacaga      120

gaucugcucc uugacccugc uugggaaaag cagcagagga aaaccuucac agccuggugc      180

aacagucauc ugcggaaggc agguacucaa aucgagaaua uugaugaaga cuuucgcgau      240

ggguugaaau uaaugcugcu acucgagguc auaagcggag aacgacugcc aaagccggag      300

cguggcaaaa ugagaguuca caagaucaac aaugugaaca aggcccuuga cuucauugcu      360

uccaaaggcg uaaagcuggu gucuaucggg gcagaggaaa uugucgaugg aaaugccaaa      420

augacguugg guaugaucug gaccauaauc cucagguuug cuauucagga caucucggug      480

gaggaaacau cagccaagga gggccugcug cucugguguc agcggaaaac ugcgcccuac      540

aagaacguua augugcagaa cuuccauauu agcuggaagg auggguuagc auuuaaugcc      600

cugauccacc gccauagacc ugagcuuaua gaauaugaca aauugaggaa ggacgaucca      660

gucaccaacc ugaauaacgc uuucgaggug gccgaaaaau accuagacau ucccaagaug      720

cucgaugcag aggacaucgu aaauacagcu cggccugaug aaaaagccau uaugaccuau      780

guuaguuccu uuuaccacgc guucucugga gcccaaaagg cagagacugc ugccaaccgc      840

aucugcaaag ugcuggcugu caaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg auuugcucga guggauccga agaacaauuc cauggcugga agacagggug      960

ccccagaaga ccauacagga gaugcaacag aaauuagagg auuuucggga cuaucgucgc     1020

gugcauaagc cuccaaaagu ccaggaaaag ugucaacugg agaucaacuu caauacgcuc     1080

cagacuaaac uuagacuguc caacaggccg gcauuuaugc ccucagaagg caagaugguu     1140

agugauauua auaacgguug gcagcacuug gagcaggccg aaaaggggua cgaggagugg     1200

cuacugaaug aaauccggcg acucgagcgc cuggaccauc uugcugaaaa auucagacaa     1260

aaggcgagca uacacgaggc auggaccgac ggaaaagagg ccaugcugaa gcacagggau     1320

uaugaaacag cuacuuuguc ugacauuaaa gcccucaucc ggaagcauga ggcauuugaa     1380

uccgaucugg ccgcucacca ggaccgcgug gagcagaucg ccgcaauugc gcaggaauua     1440

aacgagcugg auuacuauga cucacauaau guaaacacca gaugccaaaa gaucugugau     1500

cagugggacg cucuaggcag ccucacacac aguaggcgug aggcccugga gaaaaccgag     1560

aagcagcuug aagcaauuga ucaguugcau cuggaguacg ccaaacgggc ugccccuuuc     1620

aauaacugga uggaaucugc aauggaggac cuccaagaua uguucauagu gcacacgauc     1680

gaggaaauug agggccugau cuccgcucac gaccaguuua agagcacucu uccagaugcc     1740

gaccgagaaa gagaggcgau ccuggccauu cauaaagaag cucagaggau agcagagucg     1800

aaucacauca aguugucugg guccaacccc uauacaaccg ucacuccuca gauuaucaau     1860

ucaaaguggg agaaagugca acagcucguu ccaaagcgcg accaugcccu guuagaagaa     1920

cagaguaaac aacagagcaa cgaacaucug cggagacagu ucgcuuccca ggccaacgug     1980

gucggacccu ggauucaaac aaagauggag gagaucggua ggauaucuau cgaaaugaau     2040

ggcacccuag aggaucagcu cagccaccug aaacaguacg aacgcucaau uguggacuac     2100

aagccgaacc uugauuugcu ggagcagcaa caccagcuca uccaggaagc acugauuuuu     2160

gacaauaaac acacgaacua uaccauggag cauauccgag uaggguggga gcaguuacug     2220

acaacuauag cgcggaccau uaaugaaguu gagaaccaaa uccuuacacg ugaugccaag     2280

ggaauuaguc aggaacagau gcaagaguuc agagcuuccu uuaaucacuu cgacaaggau     2340

cauggcggug ccuuggggcc ugaagaguuu aaagcaugcc ucaucagccu gggcuacgac     2400

guggagaacg auaggcaggg agaagcugag uucaaucgca uaaugucucu agucgacccc     2460

aaccacucag gccuggugac uuuucaggcc uucaucgauu uuaugagucg ggaaaccaca     2520

gacaccgaua cugcagacca ggucauugcc agcuucaagg ugcucgcugg ggacaaaaau     2580

uuuaucacgg cggaggaacu gagaagggag cuuccaccug aucaagccga guauuguauu     2640

gcacgaaugg cucccuacca gggaccagac gccguucccg gugccuugga uuauaagucc     2700

uucucuacag cucuguacgg cgaaucggac uuauga                               2736


<210>  459
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  459
augguggacu accacgccgc caaccagagc uaccaguacg gccccagcag cgccggcaac       60

ggcgccggcg gcggcggcag caugggcgac uacauggccc aggaggacga cugggacaga      120

gaccugcugc uggaccccgc cugggagaag cagcagagaa agaccuucac cgccuggugc      180

aacagccacc ugagaaaggc cggcacccag aucgagaaca ucgacgagga cuucagagac      240

ggccugaagc ugaugcugcu gcuggaggug aucagcggcg agagacugcc caagcccgag      300

agaggcaaga ugagagugca caagaucaac aacgugaaca aggcccugga cuucaucgcc      360

agcaagggcg ugaagcuggu gagcaucggc gccgaggaga ucguggacgg caacgccaag      420

augacccugg gcaugaucug gaccaucauc cugagauucg ccauccagga caucagcgug      480

gaggagacca gcgccaagga gggccugcug cuguggugcc agagaaagac cgcccccuac      540

aagaacguga acgugcagaa cuuccacauc agcuggaagg acggccuggc cuucaacgcc      600

cugauccaca gacacagacc cgagcugauc gaguacgaca agcugagaaa ggacgacccc      660

gugaccaacc ugaacaacgc cuucgaggug gccgagaagu accuggacau ccccaagaug      720

cuggacgccg aggacaucgu gaacaccgcc agacccgacg agaaggccau caugaccuac      780

gugagcagcu ucuaccacgc cuucagcggc gcccagaagg ccgagaccgc cgccaacaga      840

aucugcaagg ugcuggccgu gaaccaggag aacgagcacc ugauggagga cuacgagaag      900

cuggccagcg accugcugga guggaucaga agaaccaucc ccuggcugga ggacagagug      960

ccccagaaga ccauccagga gaugcagcag aagcuggagg acuucagaga cuacagaaga     1020

gugcacaagc cccccaaggu gcaggagaag ugccagcugg agaucaacuu caacacccug     1080

cagaccaagc ugagacugag caacagaccc gccuucaugc ccagcgaggg caagauggug     1140

agcgacauca acaacggcug gcagcaccug gagcaggccg agaagggcua cgaggagugg     1200

cugcugaacg agaucagaag acuggagaga cuggaccacc uggccgagaa guucagacag     1260

aaggccagca uccacgaggc cuggaccgac ggcaaggagg ccaugcugaa gcacagagac     1320

uacgagaccg ccacccugag cgacaucaag gcccugauca gaaagcacga ggccuucgag     1380

agcgaccugg ccgcccacca ggacagagug gagcagaucg ccgccaucgc ccaggagcug     1440

aacgagcugg acuacuacga cagccacaac gugaacacca gaugccagaa gaucugcgac     1500

cagugggacg cccugggcag ccugacccac agcagaagag aggcccugga gaagaccgag     1560

aagcagcugg aggccaucga ccagcugcac cuggaguacg ccaagagagc cgcccccuuc     1620

aacaacugga uggagagcgc cauggaggac cugcaggaca uguucaucgu gcacaccauc     1680

gaggagaucg agggccugau cagcgcccac gaccaguuca agagcacccu gcccgacgcc     1740

gacagagaga gagaggccau ccuggccauc cacaaggagg cccagagaau cgccgagagc     1800

aaccacauca agcugagcgg cagcaacccc uacaccaccg ugacccccca gaucaucaac     1860

agcaaguggg agaaggugca gcagcuggug cccaagagag accacgcccu gcuggaggag     1920

cagagcaagc agcagagcaa cgagcaccug agaagacagu ucgccagcca ggccaacgug     1980

gugggccccu ggauccagac caagauggag gagaucggca gaaucagcau cgagaugaac     2040

ggcacccugg aggaccagcu gagccaccug aagcaguacg agagaagcau cguggacuac     2100

aagcccaacc uggaccugcu ggagcagcag caccagcuga uccaggaggc ccugaucuuc     2160

gacaacaagc acaccaacua caccauggag cacaucagag ugggcuggga gcagcugcug     2220

accaccaucg ccagaaccau caacgaggug gagaaccaga uccugaccag agacgccaag     2280

ggcaucagcc aggagcagau gcaggaguuc agagccagcu ucaaccacuu cgacaaggac     2340

cacggcggcg cccugggccc cgaggaguuc aaggccugcc ugaucagccu gggcuacgac     2400

guggagaacg acagacaggg cgaggccgag uucaacagaa ucaugagccu gguggacccc     2460

aaccacagcg gccuggugac cuuccaggcc uucaucgacu ucaugagcag agagaccacc     2520

gacaccgaca ccgccgacca ggugaucgcc agcuucaagg ugcuggccgg cgacaagaac     2580

uucaucaccg ccgaggagcu gagaagagag cugccccccg accaggccga guacugcauc     2640

gccagaaugg cccccuacca gggccccgac gccgugcccg gcgcccugga cuacaagagc     2700

uucagcaccg cccuguacgg cgagagcgac cuguga                               2736


<210>  460
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       alpha-actinin-_4/m__Homo_sapiens__AAH05033

<400>  460
augguggacu accacgccgc uaaccagagc uaucaauacg gccccuccuc ugccgggaau       60

ggagcgggcg ggggaggcag caugggggau uauauggcuc aggaggacga uugggacaga      120

gaucugcucc uggacccugc cugggaaaag cagcagcgga aaaccuucac agccuggugc      180

aacucccauc uucgcaaggc uggaacgcaa aucgagaaua uugaugaaga cuuuagagau      240

ggccugaaac ucaugcugcu ucuggagguc aucucuggcg aacggcuccc gaagcccgag      300

cgcgggaaaa ugagaguuca caagauuaac aaugugaaca aggcccugga cuucaucgcu      360

agcaaaggag ugaagcuggu cuccauuggc gccgaggaaa ucguggaugg gaaugcgaaa      420

augacccucg gaaugaucug gacaauuauc cugcgguuug ccauucagga caucucuguu      480

gaggaaacca gcgcuaagga gggccuucug cucugguguc agcgcaaaac agccccuuac      540

aagaacguga auguccagaa cuuccauauu uccuggaagg augggcuggc uuuuaaugcc      600

cuuauccaca gacaucggcc cgagcugauu gaauaugaca aacuccgcaa ggacgauccu      660

gugaccaacc ugaauaacgc guucgagguu gccgaaaaau accuggacau ccccaagaug      720

cucgaugcug aggacaucgu gaauacagcc agaccugaug aaaaagcuau uaugaccuau      780

gucagcucuu uuuaccacgc cuucuccgga gcccaaaagg cugagacggc ggccaaccgg      840

aucugcaaag ugcuggcugu gaaccaggag aaugaacacc uuauggagga cuacgaaaag      900

cuggccagcg aucuccugga guggauucgc agaaccaucc cguggcuuga agaccggguc      960

ccccagaaga caauucagga gaugcaacag aaacuggagg auuuucgcga cuauagacgg     1020

guucauaagc cucccaaagu gcaggaaaag ugucaacucg agaucaacuu caauacccug     1080

cagacaaaac ugagacucuc uaaccgcccu gccuuuaugc ccuccgaagg caagauggug     1140

agcgauauca auaacggcug gcagcaccug gagcaggcug aaaaggggua cgaggagugg     1200

cuucugaaug aaauucggag acucgagcgc cuggaccauc uugccgaaaa auuccggcaa     1260

aaggcgucua uccacgaggc uuggaccgac ggaaaagagg ccaugcugaa gcacagagau     1320

uaugaaacgg ccacacucuc cgacauuaaa gcucugaucc gcaagcauga ggccuuugaa     1380

agcgaucugg cugcccacca ggaccggguc gagcagauug cggccaucgc ucaggaacuc     1440

aacgagcugg auuacuauga cucccauaau gugaacacca gaugccaaaa gaucugugau     1500

cagugggacg cccuuggcuc ucugacacac agccgccggg aggcucucga gaaaaccgag     1560

aagcagcugg aagccauuga ucagcugcau cuugaguacg cgaaaagagc cgcuccguuc     1620

aauaacugga uggaauccgc cauggaggac cuccaagaua uguucaucgu ucacaccauu     1680

gaggaaaucg aggggcugau uagcgcucac gaccaguuua agucuacacu gccugaugcc     1740

gaccgcgaac gggaggccau ccucgcuauu cauaaagaag cgcagagaau cgccgagucc     1800

aaucacauca agcugagcgg aucuaacccc uauacgaccg ugacaccuca gauuaucaau     1860

agcaaguggg agaaagucca acagcuugug cccaagcggg accaugcucu gcucgaagaa     1920

caguccaaac aacagucuaa cgaacaucug cgcagacagu ucgccagcca ggccaacguu     1980

gugggccccu ggauucaaac caagauggag gagaucgggc ggauuuccau cgaaaugaau     2040

ggaacacugg aggaucagcu uagccaccuc aaacaguacg aaagaucuau cgucgacuac     2100

aagccuaacc uggaucugcu cgagcagcaa caccagcuga uucaggaagc ucuuaucuuu     2160

gacaauaaac acaccaacua uacgauggag cauauucgcg ugggcuggga gcagcugcuc     2220

acaaccaucg cccggaccau uaaugaaguc gagaaccaaa uccugacaag agaugcgaag     2280

ggcaucuccc aggaacagau gcaagaguuc cgcgcuagcu uuaaucacuu cgacaaggau     2340

caugggggag cccugggccc ggaagaguuu aaagccugcc uuauuucucu cggguacgac     2400

guggagaacg auagacaggg agaagcugag uucaaucgga ucaugucccu gguugacccc     2460

aaccacagcg gccuggugac cuuucaggcc uucauugauu uuaugucccg cgaaacaacg     2520

gacaccgaua cagcggacca ggucaucgcu ucuuucaagg ugcucgccgg ggacaaaaau     2580

uuuauuaccg ccgaggaacu gagacgggag cuuccucccg aucaagcuga guauuguauc     2640

gcccgcaugg cuccuuacca gggccccgac gccguuccgg gagcgcugga uuauaagagc     2700

uucuccacag cccucuacgg cgaaucugac cuguga                               2736


<210>  461
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__A0A024RE16

<400>  461

Met Ala Leu Gln Gly Ile Ser Val Met Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Gly Arg Asn Ser Ile Phe Lys Phe Phe Ser Val Glu Asn 
    130                 135                 140                 


Ser Glu Ile Glu Ser Val Gly Ser Thr Ser Arg Thr Glu His Val Gly 
145                 150                 155                 160 


Trp Trp Ser Thr Phe Leu Tyr Asp Leu Gln Asp Ser Arg Trp Gly Ile 
                165                 170                 175     


His Gly Cys Trp Ser Asn Arg Thr Pro Val Leu Arg Ala Ala Asp Gln 
            180                 185                 190         


Arg Thr Trp Thr Lys Val 
        195             


<210>  462
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  462
auggcacugc agggcaucuc ggucauggag cuguccggcc uggccccggg cccguucugu       60

gcuauggucc uggcugacuu cggggcgcgu gugguacgcg uggaccggcc cggcucccgc      120

uacgacguga gccgcuuggg ccggggcaag cgcucgcuag ugcuggaccu gaagcagccg      180

cggggagccg ccgugcugcg gcgucugugc aagcggucgg augugcugcu ggagcccuuc      240

cgccgcggug ucauggagaa acuccagcug ggcccagaga uucugcagcg ggaaaaucca      300

aggcuuauuu augccaggcu gaguggauuu ggccagucag gaagcuucug ccgguuagcu      360

ggccacgaua ucaacuauuu ggcuuuguca gguggaagga acagcauauu uaaguucuuu      420

ucuguggaaa acucagaaau cgagucugug ggaagcaccu cgaggacaga acauguugga      480

ugguggagca ccuuucuaua cgacuuacag gacagcagau ggggaauuca uggcuguugg      540

agcaauagaa ccccaguucu acgagcugcu gaucaaagga cuuggacuaa agucuga         597


<210>  463
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  463
auggcccugc agggcaucag cgugauggag cucuccgggc uggcccccgg cccguucugc       60

gcgauggucc uggccgacuu cggggcccgc guggugcggg ucgaccgccc cggcagccgg      120

uacgacgugu cccgccucgg gcggggcaag cgcagccugg ugcuggaccu caagcagccc      180

cggggcgccg ccguccugcg ccggcugugc aagcgcuccg acgugcuccu ggagcccuuc      240

cggcgcgggg ugauggagaa gcugcagcuc ggcccggaga uccugcagcg ggagaacccc      300

cgccugaucu acgcgcggcu cagcggguuc ggccaguccg ggagcuucug ccgccuggcc      360

ggccacgaca ucaacuaccu ggcccucucc ggcgggcgga acagcaucuu caaguucuuc      420

uccgucgaga acagcgagau cgaguccgug ggcagcaccu cccgcaccga gcacgugggg      480

ugguggagca cguuccugua cgaccugcag gacucccggu ggggcaucca cggcugcugg      540

agcaaccgca cccccguccu ccgggccgcg gaccagcgca ccuggaccaa gguguga         597


<210>  464
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  464
auggcccucc agggcaucuc cgucauggag cucuccggcc ucgcccccgg ccccuucugc       60

gccauggucc ucgccgacuu cggcgcccgc gucguccgcg ucgaccgccc cggcucccgc      120

uacgacgucu cccgccucgg ccgcggcaag cgcucccucg uccucgaccu caagcagccc      180

cgcggcgccg ccguccuccg ccgccucugc aagcgcuccg acguccuccu cgagcccuuc      240

cgccgcggcg ucauggagaa gcuccagcuc ggccccgaga uccuccagcg cgagaacccc      300

cgccucaucu acgcccgccu cuccggcuuc ggccaguccg gcuccuucug ccgccucgcc      360

ggccacgaca ucaacuaccu cgcccucucc ggcggccgca acuccaucuu caaguucuuc      420

uccgucgaga acuccgagau cgaguccguc ggcuccaccu cccgcaccga gcacgucggc      480

ugguggucca ccuuccucua cgaccuccag gacucccgcu ggggcaucca cggcugcugg      540

uccaaccgca cccccguccu ccgcgccgcc gaccagcgca ccuggaccaa ggucuga         597


<210>  465
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  465
auggcccugc agggcaucag cgugauggag cucuccgggc uugcucccgg accuuucugc       60

gcaauggucc uggccgacuu uggugcgaga guugugaggg uagaucggcc aggcucucgc      120

uacgacgugu cacgauuggg gcguggaaag agaaguuuag uccuggaucu aaaacaaccg      180

aggggcgcug ccgugcuccg gcgccugugu aagagaagcg acguucuucu ggaacccuuc      240

aggcggggug ugauggagaa auugcagcuc gggccugaaa uucugcagcg cgagaaccca      300

cgacugauau augcaagacu cuccggauuu ggccagucug gcucguucug cagguuagcc      360

gggcacgaua ucaauuaccu ggcucuuuca ggaggucgga acagcauuuu uaaguucuuu      420

agugucgaaa auuccgagau cgagucugug ggcagcaccu cccguacaga acauguaggg      480

ugguggucaa cuuucuugua ugaccugcaa gauagucgcu ggggcauuca cggauguugg      540

agcaacagaa cgcccguucu aagggcagcc gaccagcgga ccuggacaaa aguguga         597


<210>  466
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  466
auggcccugc agggcaucag cgugauggag cugagcggcc uggcccccgg ccccuucugc       60

gccauggugc uggccgacuu cggcgccaga guggugagag uggacagacc cggcagcaga      120

uacgacguga gcagacuggg cagaggcaag agaagccugg ugcuggaccu gaagcagccc      180

agaggcgccg ccgugcugag aagacugugc aagagaagcg acgugcugcu ggagcccuuc      240

agaagaggcg ugauggagaa gcugcagcug ggccccgaga uccugcagag agagaacccc      300

agacugaucu acgccagacu gagcggcuuc ggccagagcg gcagcuucug cagacuggcc      360

ggccacgaca ucaacuaccu ggcccugagc ggcggcagaa acagcaucuu caaguucuuc      420

agcguggaga acagcgagau cgagagcgug ggcagcacca gcagaaccga gcacgugggc      480

ugguggagca ccuuccugua cgaccugcag gacagcagau ggggcaucca cggcugcugg      540

agcaacagaa cccccgugcu gagagccgcc gaccagagaa ccuggaccaa gguguga         597


<210>  467
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__EAX10817

<400>  467
auggcccugc agggcaucag cgugauggag cucuccgggc uggcucccgg accuuucugc       60

gccauggucc uugcggacuu uggcgcuaga guugugcggg uggaucgccc ggggucuaga      120

uacgacguca gccggcuggg acgcggcaag agaucccucg ugcuggaucu uaaacaaccc      180

cgcggggccg ccguucugcg gagacucugu aagcggucug acgugcugcu ggaaccuuuc      240

cgcagaggag ucauggagaa acuccagcug ggccccgaaa uucuucagcg ggagaacccu      300

cgccugaucu augcuagacu cagcggcuuu gggcaguccg gaucuuucug ccggcuggcc      360

ggccacgaua uuaauuaccu ugcucugagc gggggacgca acuccaucuu uaaguucuuu      420

agcguggaaa auucugagau ugaguccguu ggcagcaccu cuagaacaga acaugugggg      480

ugguggucca cguuccucua ugaccugcaa gauagccggu ggggaaucca cggcuguugg      540

ucuaacagaa cccccguccu gcgcgccgcg gaccagcgga cauggaccaa aguguga         597


<210>  468
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__A8KAC3

<400>  468

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Gly Arg Asn Ser Ile Phe Lys Phe Phe Ser Val Glu Asn 
    130                 135                 140                 


Ser Glu Ile Glu Ser Val Gly Ser Thr Ser Arg Thr Glu His Val Gly 
145                 150                 155                 160 


Trp Trp Ser Thr Phe Leu Tyr Asp Leu Gln Asp Ser Arg Trp Gly Ile 
                165                 170                 175     


His Gly Cys Trp Ser Asn Arg Thr Pro Phe Leu Arg Ala Ala Asp Gln 
            180                 185                 190         


Arg Thr Trp Thr Lys Val 
        195             


<210>  469
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  469
auggcacugc agggcaucuc ggucguggag cuguccggcc uggccccggg cccguucugu       60

gcuauggucc uggcugacuu cggggcgcgu gugguacgcg uggaccggcc cggcucccgc      120

uacgacguga gccgcuuggg ccggggcaag cgcucgcuag ugcuggaccu gaagcagccg      180

cggggagccg ccgugcugcg gcgucugugc aagcggucgg augugcugcu ggagcccuuc      240

cgccgcggug ucauggagaa acuccagcug ggcccagaga uucugcagcg ggaaaaucca      300

aggcuuauuu augccaggcu gaguggauuu ggccagucag gaagcuucug ccgguuagcu      360

ggccacgaua ucaacuauuu ggcuuuguca gguggaagga acagcauauu uaaguucuuu      420

ucuguggaaa acucagaaau cgagucugug ggaagcaccu cgaggacaga acauguugga      480

ugguggagca ccuuucuaua cgacuuacag gacagcagau ggggaauuca uggcuguugg      540

agcaauagaa ccccauuucu acgagcugcu gaucaaagga cuuggacuaa agucuga         597


<210>  470
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  470
auggcccugc agggcaucag cguggucgag cucuccgggc uggcccccgg cccguucugc       60

gcgauggugc uggccgacuu cggggcccgc gugguccggg uggaccgccc cggcagccgg      120

uacgacgugu cccgccucgg gcggggcaag cgcagccugg uccuggaccu caagcagccc      180

cggggcgccg ccgugcugcg ccggcugugc aagcgcuccg acgugcuccu ggagcccuuc      240

cggcgcgggg ucauggagaa gcugcagcuc ggcccggaga uccugcagcg ggagaacccc      300

cgccugaucu acgcgcggcu cagcggguuc ggccaguccg ggagcuucug ccgccuggcc      360

ggccacgaca ucaacuaccu ggcccucucc ggcgggcgga acagcaucuu caaguucuuc      420

uccguggaga acagcgagau cgaguccgug ggcagcaccu cccgcaccga gcacgucggg      480

ugguggagca cguuccugua cgaccugcag gacucccggu ggggcaucca cggcugcugg      540

agcaaccgca cccccuuccu ccgggccgcg gaccagcgca ccuggaccaa gguguga         597


<210>  471
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  471
auggcccucc agggcaucuc cgucgucgag cucuccggcc ucgcccccgg ccccuucugc       60

gccauggucc ucgccgacuu cggcgcccgc gucguccgcg ucgaccgccc cggcucccgc      120

uacgacgucu cccgccucgg ccgcggcaag cgcucccucg uccucgaccu caagcagccc      180

cgcggcgccg ccguccuccg ccgccucugc aagcgcuccg acguccuccu cgagcccuuc      240

cgccgcggcg ucauggagaa gcuccagcuc ggccccgaga uccuccagcg cgagaacccc      300

cgccucaucu acgcccgccu cuccggcuuc ggccaguccg gcuccuucug ccgccucgcc      360

ggccacgaca ucaacuaccu cgcccucucc ggcggccgca acuccaucuu caaguucuuc      420

uccgucgaga acuccgagau cgaguccguc ggcuccaccu cccgcaccga gcacgucggc      480

ugguggucca ccuuccucua cgaccuccag gacucccgcu ggggcaucca cggcugcugg      540

uccaaccgca cccccuuccu ccgcgccgcc gaccagcgca ccuggaccaa ggucuga         597


<210>  472
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  472
auggcccugc agggcaucag cguggucgag cucuccgggc uugcucccgg accuuucugc       60

gcaaugguuc uggccgacuu uggugcgaga gugguaaggg uggaucggcc aggcucucgc      120

uacgacgucu cacgauuggg gcguggaaag agaaguuuag ugcuggaucu aaaacaaccg      180

aggggcgcug ccguucuccg gcgccugugu aagagaagcg acgugcuucu ggaacccuuc      240

aggcggggug ucauggagaa auugcagcuc gggccugaaa uucugcagcg cgagaaccca      300

cgacugauau augcaagacu cuccggauuu ggccagucug gcucguucug cagguuagcc      360

gggcacgaua ucaauuaccu ggcucuuuca ggaggucgga acagcauuuu uaaguucuuu      420

aguguggaaa auuccgagau cgagucugua ggcagcaccu cccguacaga acauguuggg      480

ugguggucaa cuuucuugua ugaccugcaa gauagucgcu ggggcauuca cggauguugg      540

agcaacagaa cgcccuuucu aagggcagcc gaccagcgga ccuggacaaa aguguga         597


<210>  473
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  473
auggcccugc agggcaucag cgugguggag cugagcggcc uggcccccgg ccccuucugc       60

gccauggugc uggccgacuu cggcgccaga guggugagag uggacagacc cggcagcaga      120

uacgacguga gcagacuggg cagaggcaag agaagccugg ugcuggaccu gaagcagccc      180

agaggcgccg ccgugcugag aagacugugc aagagaagcg acgugcugcu ggagcccuuc      240

agaagaggcg ugauggagaa gcugcagcug ggccccgaga uccugcagag agagaacccc      300

agacugaucu acgccagacu gagcggcuuc ggccagagcg gcagcuucug cagacuggcc      360

ggccacgaca ucaacuaccu ggcccugagc ggcggcagaa acagcaucuu caaguucuuc      420

agcguggaga acagcgagau cgagagcgug ggcagcacca gcagaaccga gcacgugggc      480

ugguggagca ccuuccugua cgaccugcag gacagcagau ggggcaucca cggcugcugg      540

agcaacagaa cccccuuccu gagagccgcc gaccagagaa ccuggaccaa gguguga         597


<210>  474
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       alpha-methylacyl-coenzyme_A_racemase__Homo_sapiens__BAF85677

<400>  474
auggcccugc agggcaucag cguggucgag cucuccgggc uggcucccgg accuuucugc       60

gccaugguuc uugcggacuu uggcgcuaga guggugcggg ucgaucgccc ggggucuaga      120

uacgacguga gccggcuggg acgcggcaag agaucccucg uucuggaucu uaaacaaccc      180

cgcggggccg ccgugcugcg gagacucugu aagcggucug acguccugcu ggaaccuuuc      240

cgcagaggag ugauggagaa acuccagcug ggccccgaaa uucuucagcg ggagaacccu      300

cgccugaucu augcuagacu cagcggcuuu gggcaguccg gaucuuucug ccggcuggcc      360

ggccacgaua uuaauuaccu ugcucugagc gggggacgca acuccaucuu uaaguucuuu      420

agcguugaaa auucugagau ugaguccgug ggcagcaccu cuagaacaga acaugucggg      480

ugguggucca cguuccucua ugaccugcaa gauagccggu ggggaaucca cggcuguugg      540

ucuaacagaa cccccuuucu gcgcgccgcg gaccagcgga cauggaccaa aguguga         597


<210>  475
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ANDR__Homo_sapiens__P10275

<400>  475

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  476
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ANDR__Homo_sapiens__EAX05380

<400>  476
auggaagugc aguuagggcu gggaaggguc uacccucggc cgccguccaa gaccuaccga       60

ggagcuuucc agaaucuguu ccagagcgug cgcgaaguga uccagaaccc gggccccagg      120

cacccagagg ccgcgagcgc agcaccuccc ggcgccaguu ugcugcugcu gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcaa      240

gagacuagcc ccaggcagca gcagcagcag cagggugagg augguucucc ccaagcccau      300

cguagaggcc ccacaggcua ccugguccug gaugaggaac agcaaccuuc acagccgcag      360

ucggcccugg agugccaccc cgagagaggu ugcgucccag agccuggagc cgccguggcc      420

gccagcaagg ggcugccgca gcagcugcca gcaccuccgg acgaggauga cucagcugcc      480

ccauccacgu ugucccugcu gggccccacu uuccccggcu uaagcagcug cuccgcugac      540

cuuaaagaca uccugagcga ggccagcacc augcaacucc uucagcaaca gcagcaggaa      600

gcaguauccg aaggcagcag cagcgggaga gcgagggagg ccucgggggc ucccacuucc      660

uccaaggaca auuacuuagg gggcacuucg accauuucug acaacgccaa ggaguugugu      720

aaggcagugu cgguguccau gggccugggu guggaggcgu uggagcaucu gaguccaggg      780

gaacagcuuc ggggggauug cauguacgcc ccacuuuugg gaguuccacc cgcugugcgu      840

cccacuccuu gugccccauu ggccgaaugc aaagguucuc ugcuagacga cagcgcaggc      900

aagagcacug aagauacugc ugaguauucc ccuuucaagg gagguuacac caaagggcua      960

gaaggcgaga gccuaggcug cucuggcagc gcugcagcag ggagcuccgg gacacuugaa     1020

cugccgucua cccugucucu cuacaagucc ggagcacugg acgaggcagc ugcguaccag     1080

agucgcgacu acuacaacuu uccacuggcu cuggccggac cgccgccccc uccgccgccu     1140

ccccaucccc acgcucgcau caagcuggag aacccgcugg acuacggcag cgccugggcg     1200

gcugcggcgg cgcagugccg cuauggggac cuggcgagcc ugcauggcgc gggugcagcg     1260

ggacccgguu cugggucacc cucagccgcc gcuuccucau ccuggcacac ucucuucaca     1320

gccgaagaag gccaguugua uggaccgugu ggugguggug gggguggugg cggcggcggc     1380

ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg aggcgggagc uguagccccc     1440

uacggcuaca cucggccccc ucaggggcug gcgggccagg aaagcgacuu caccgcaccu     1500

gauguguggu acccuggcgg cauggugagc agagugcccu aucccagucc cacuuguguc     1560

aaaagcgaaa ugggccccug gauggauagc uacuccggac cuuacgggga caugcguuug     1620

gagacugcca gggaccaugu uuugcccauu gacuauuacu uuccacccca gaagaccugc     1680

cugaucugug gagaugaagc uucugggugu cacuauggag cucucacaug uggaagcugc     1740

aaggucuucu ucaaaagagc cgcugaaggg aaacagaagu accugugcgc cagcagaaau     1800

gauugcacua uugauaaauu ccgaaggaaa aauuguccau cuugucgucu ucggaaaugu     1860

uaugaagcag ggaugacucu gggagcccgg aagcugaaga aacuugguaa ucugaaacua     1920

caggaggaag gagaggcuuc cagcaccacc agccccacug aggagacaac ccagaagcug     1980

acagugucac acauugaagg cuaugaaugu cagcccaucu uucugaaugu ccuggaagcc     2040

auugagccag guguagugug ugcuggacac gacaacaacc agcccgacuc cuuugcagcc     2100

uugcucucua gccucaauga acugggagag agacagcuug uacacguggu caagugggcc     2160

aaggccuugc cuggcuuccg caacuuacac guggacgacc agauggcugu cauucaguac     2220

uccuggaugg ggcucauggu guuugccaug ggcuggcgau ccuucaccaa ugucaacucc     2280

aggaugcucu acuucgcccc ugaucugguu uucaaugagu accgcaugca caagucccgg     2340

auguacagcc aguguguccg aaugaggcac cucucucaag aguuuggaug gcuccaaauc     2400

accccccagg aauuccugug caugaaagca cugcuacucu ucagcauuau uccaguggau     2460

gggcugaaaa aucaaaaauu cuuugaugaa cuucgaauga acuacaucaa ggaacucgau     2520

cguaucauug caugcaaaag aaaaaauccc acauccugcu caagacgcuu cuaccagcuc     2580

accaagcucc uggacuccgu gcagccuauu gcgagagagc ugcaucaguu cacuuuugac     2640

cugcuaauca agucacacau ggugagcgug gacuuuccgg aaaugauggc agagaucauc     2700

ucugugcaag ugcccaagau ccuuucuggg aaagucaagc ccaucuauuu ccacacccag     2760

uga                                                                   2763


<210>  477
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ANDR__Homo_sapiens__EAX05380

<400>  477
auggaggugc agcugggccu cgggcgcguc uacccccggc cgcccagcaa gaccuaccgc       60

ggcgccuucc agaaccuguu ccaguccgug cgggagguga uccagaaccc cgggccccgc      120

cacccggagg ccgcgagcgc cgcccccccc ggcgccuccc ugcuccugcu gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      240

gagaccagcc cccggcagca gcagcagcag cagggggagg acggcucccc gcaggcccac      300

cgccggggcc ccacggggua ccucguccug gacgaggagc agcagcccag ccagccccag      360

uccgcgcugg agugccaccc ggagcgcggc ugcgugcccg agcccggggc cgccguggcc      420

gcgagcaagg gccuccccca gcagcugccg gccccccccg acgaggacga cuccgccgcc      480

cccagcaccc ugucccuccu ggggccgacc uuccccggcc ugagcuccug cagcgccgac      540

cucaaggaca uccuguccga ggcgagcacc augcagcugc uccagcagca gcagcaggag      600

gccgucuccg agggcagcuc cagcgggcgg gcccgcgagg ccagcggcgc ccccacgucc      660

agcaaggaca acuaccuggg gggcaccucc accaucagcg acaacgcgaa ggagcugugc      720

aaggccgugu ccgugagcau gggccucggg gucgaggccc uggagcaccu gucccccggc      780

gagcagcucc ggggggacug cauguacgcc ccgcugcugg gcgugccccc cgccgugcgc      840

cccaccccgu gcgcgccccu cgccgagugc aaggggagcc ugcuggacga cuccgccggc      900

aagagcacgg aggacaccgc cgaguacucc cccuucaagg gcggguacac caagggccuc      960

gagggggaga gccugggcug cuccgggagc gccgcggccg gcuccagcgg cacccuggag     1020

cucccgucca cgcugagccu guacaagucc ggggcccucg acgaggccgc ggccuaccag     1080

agccgggacu acuacaacuu cccccuggcc cuggccggcc cccccccgcc cccccccccg     1140

ccccaccccc acgcccgcau caagcucgag aacccccugg acuacgggag cgcgugggcc     1200

gccgccgccg cgcagugccg guacggcgac cuggccuccc uccacggggc cggcgccgcc     1260

ggcccgggga gcggcucccc cagcgcggcc gccuccagcu ccuggcacac ccuguucacc     1320

gccgaggagg ggcagcugua cggccccugc ggcgggggcg ggggcggggg cggcgggggc     1380

gggggcgggg gcggcggggg cgggggcggg ggcggcgggg aggcgggcgc cgucgccccc     1440

uacggguaca cccgcccgcc ccagggccuc gccgggcagg agagcgacuu cacggccccc     1500

gacguguggu accccggcgg cauggugucc cgggucccgu accccagccc caccugcgug     1560

aaguccgaga uggggcccug gauggacagc uacuccggcc cguacgggga caugcgccug     1620

gagaccgcgc gggaccacgu gcugcccauc gacuacuacu uccccccgca gaagaccugc     1680

cucaucugcg gcgacgaggc cagcggcugc cacuacgggg cccugacgug cggcuccugc     1740

aaggucuucu ucaagcgcgc cgccgagggg aagcagaagu accugugcgc gagccggaac     1800

gacugcacca ucgacaaguu ccgccgcaag aacugccccu ccugccggcu gcgcaagugc     1860

uacgaggccg gcaugacccu cggggcccgg aagcugaaga agcugggcaa ccucaagcug     1920

caggaggagg gcgaggccag cagcaccacg ucccccaccg aggagaccac ccagaagcug     1980

acggugagcc acaucgaggg guacgagugc cagcccaucu uccucaacgu gcuggaggcc     2040

aucgagccgg gcgucgugug cgcggggcac gacaacaacc agcccgacuc cuucgccgcc     2100

cugcucagcu cccugaacga gcugggcgag cgccagcucg ugcacgucgu gaagugggcc     2160

aaggcgcugc ccggguuccg gaaccugcac gucgacgacc agauggccgu gauccaguac     2220

agcuggaugg gccucauggu guucgccaug ggcuggcgcu ccuucaccaa cgucaacagc     2280

cggaugcugu acuucgcccc cgaccuggug uucaacgagu accgcaugca caagucccgg     2340

auguacagcc agugcgugcg caugcggcac cucucccagg aguucgggug gcugcagauc     2400

accccgcagg aguuccugug caugaaggcc cuccugcugu ucagcaucau ccccgucgac     2460

ggccucaaga accagaaguu cuucgacgag cugcgcauga acuacaucaa ggagcuggac     2520

cggaucaucg cgugcaagcg caagaacccc accuccugca gccggcgcuu cuaccagcuc     2580

acgaagcugc uggacuccgu gcagcccauc gcccgggagc uccaccaguu caccuucgac     2640

cugcugauca agagccacau gguguccguc gacuucccgg agaugauggc cgagaucauc     2700

agcgugcagg ugcccaagau ccucuccggg aaggucaagc ccaucuacuu ccacacccag     2760

uga                                                                   2763


<210>  478
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ANDR__Homo_sapiens__EAX05380

<400>  478
auggaggucc agcucggccu cggccgcguc uacccccgcc cccccuccaa gaccuaccgc       60

ggcgccuucc agaaccucuu ccaguccguc cgcgagguca uccagaaccc cggcccccgc      120

caccccgagg ccgccuccgc cgcccccccc ggcgccuccc uccuccuccu ccagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      240

gagaccuccc cccgccagca gcagcagcag cagggcgagg acggcucccc ccaggcccac      300

cgccgcggcc ccaccggcua ccucguccuc gacgaggagc agcagcccuc ccagccccag      360

uccgcccucg agugccaccc cgagcgcggc ugcguccccg agcccggcgc cgccgucgcc      420

gccuccaagg gccuccccca gcagcucccc gccccccccg acgaggacga cuccgccgcc      480

cccuccaccc ucucccuccu cggccccacc uuccccggcc ucuccuccug cuccgccgac      540

cucaaggaca uccucuccga ggccuccacc augcagcucc uccagcagca gcagcaggag      600

gccgucuccg agggcuccuc cuccggccgc gcccgcgagg ccuccggcgc ccccaccucc      660

uccaaggaca acuaccucgg cggcaccucc accaucuccg acaacgccaa ggagcucugc      720

aaggccgucu ccgucuccau gggccucggc gucgaggccc ucgagcaccu cucccccggc      780

gagcagcucc gcggcgacug cauguacgcc ccccuccucg gcgucccccc cgccguccgc      840

cccacccccu gcgccccccu cgccgagugc aagggcuccc uccucgacga cuccgccggc      900

aaguccaccg aggacaccgc cgaguacucc cccuucaagg gcggcuacac caagggccuc      960

gagggcgagu cccucggcug cuccggcucc gccgccgccg gcuccuccgg cacccucgag     1020

cuccccucca cccucucccu cuacaagucc ggcgcccucg acgaggccgc cgccuaccag     1080

ucccgcgacu acuacaacuu cccccucgcc cucgccggcc cccccccccc cccccccccc     1140

ccccaccccc acgcccgcau caagcucgag aacccccucg acuacggcuc cgccugggcc     1200

gccgccgccg cccagugccg cuacggcgac cucgccuccc uccacggcgc cggcgccgcc     1260

ggccccggcu ccggcucccc cuccgccgcc gccuccuccu ccuggcacac ccucuucacc     1320

gccgaggagg gccagcucua cggccccugc ggcggcggcg gcggcggcgg cggcggcggc     1380

ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg aggccggcgc cgucgccccc     1440

uacggcuaca cccgcccccc ccagggccuc gccggccagg aguccgacuu caccgccccc     1500

gacgucuggu accccggcgg cauggucucc cgcguccccu accccucccc caccugcguc     1560

aaguccgaga ugggccccug gauggacucc uacuccggcc ccuacggcga caugcgccuc     1620

gagaccgccc gcgaccacgu ccuccccauc gacuacuacu ucccccccca gaagaccugc     1680

cucaucugcg gcgacgaggc cuccggcugc cacuacggcg cccucaccug cggcuccugc     1740

aaggucuucu ucaagcgcgc cgccgagggc aagcagaagu accucugcgc cucccgcaac     1800

gacugcacca ucgacaaguu ccgccgcaag aacugccccu ccugccgccu ccgcaagugc     1860

uacgaggccg gcaugacccu cggcgcccgc aagcucaaga agcucggcaa ccucaagcuc     1920

caggaggagg gcgaggccuc cuccaccacc ucccccaccg aggagaccac ccagaagcuc     1980

accgucuccc acaucgaggg cuacgagugc cagcccaucu uccucaacgu ccucgaggcc     2040

aucgagcccg gcgucgucug cgccggccac gacaacaacc agcccgacuc cuucgccgcc     2100

cuccucuccu cccucaacga gcucggcgag cgccagcucg uccacgucgu caagugggcc     2160

aaggcccucc ccggcuuccg caaccuccac gucgacgacc agauggccgu cauccaguac     2220

uccuggaugg gccucauggu cuucgccaug ggcuggcgcu ccuucaccaa cgucaacucc     2280

cgcaugcucu acuucgcccc cgaccucguc uucaacgagu accgcaugca caagucccgc     2340

auguacuccc agugcguccg caugcgccac cucucccagg aguucggcug gcuccagauc     2400

accccccagg aguuccucug caugaaggcc cuccuccucu ucuccaucau ccccgucgac     2460

ggccucaaga accagaaguu cuucgacgag cuccgcauga acuacaucaa ggagcucgac     2520

cgcaucaucg ccugcaagcg caagaacccc accuccugcu cccgccgcuu cuaccagcuc     2580

accaagcucc ucgacuccgu ccagcccauc gcccgcgagc uccaccaguu caccuucgac     2640

cuccucauca agucccacau ggucuccguc gacuuccccg agaugauggc cgagaucauc     2700

uccguccagg uccccaagau ccucuccggc aaggucaagc ccaucuacuu ccacacccag     2760

uga                                                                   2763


<210>  479
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ANDR__Homo_sapiens__EAX05380

<400>  479
auggaggugc agcugggccu cgggagaguc uaccccaggc cuccaagcaa gaccuaucgg       60

ggagccuucc aaaaccuuuu ucaguccguu cgcgaaguga uccagaaucc ggguccccga      120

cacccugagg cugcaucugc cgcgccaccc ggcgcuucac uguuguuacu gcagcaacag      180

cagcagcaac agcagcagca acagcagcaa cagcagcagc aacagcagca gcaacagcag      240

gaaacaaguc cucgucagca acagcagcag caaggggagg acggaagccc acaggcccau      300

agaaggggcc ccacugguua ccuaguacuc gaugaggaac agcaaccuuc ccagccacag      360

ucugcacugg agugccaccc ggaacggggg ugugugcccg agccuggagc cgcugucgca      420

gccucgaaag gccuuccaca gcaacugccc gcuccuccag acgaagauga cucagccgcg      480

cccagcacgu ugagucuccu gggcccgacc uucccugggc uguccucuug cagcgcagau      540

cucaaggaca uuuuauccga ggccucaaca augcagcugc uucagcagca acagcaggag      600

gcugugagug aaggaagcag cuccggucgc gccagagagg caucaggcgc ucccacuagc      660

aguaaagaua acuaucuugg gggaaccucu acaauauccg acaaugccaa ggaacugugu      720

aaagcgguua gcgugucgau gggccuaggu gucgaggccc ucgaacaucu gucuccaggg      780

gagcagcuua ggggagauug cauguacgca ccucuguugg gcgugccccc agcuguacgg      840

cccaccccuu gugccccacu cgcugagugc aagggcuccc uguuagacga uucagccggg      900

aagaguacug aagacacagc agaguauagc ccguuuaaag gagguuacac caagggccug      960

gaaggggagu cccucggaug uucuggcagc gccgcugcgg guucaagugg gacgcuugaa     1020

cugcccucca cuuugagccu auauaaaucu ggcgcacugg augaggccgc ugccuaccaa     1080

ucacgcgacu acuauaacuu cccucucgca cuggccggac cacccccucc acccccgccu     1140

ccacaccccc augcucgaau caaguuggag aauccucugg acuacggcag ugccugggca     1200

gcggcugccg cacagugcag auauggggau uuggccagcc uccacggagc uggugccgca     1260

ggccccgggu ccggaucucc aucggcugcc gcgagcuccu cauggcacac ccuguuuaca     1320

gccgaagagg gccaguuaua cgguccuugu gggggcggag gcgggggagg uggcggggga     1380

ggcggugggg gcggaggcgg gggaggcggu gggggaggcg aagcuggugc aguugccccc     1440

uauggcuaca cuaggccacc gcaagggcug gcuggacagg agagugacuu caccgccccu     1500

gauguguggu aucccggcgg gauggucucu cgggugccau accccagccc uacaugcgug     1560

aaauccgaaa ugggaccaug gauggacuca uacagcggcc ccuaugguga uaugcgucua     1620

gagaccgcac gcgaccaugu ccucccuauu gauuacuauu uuccgccaca gaagacgugu     1680

cugaucugcg gggacgaggc gucuggaugc cacuacggcg cccuuacuug ugguuccugc     1740

aagguuuucu uuaaaagagc ugccgaaggc aagcagaaau auuugugugc aaguaggaac     1800

gauugcacaa uugacaaguu ccggcgaaag aauuguccca gcugccgccu gagaaagugu     1860

uacgaggcug ggaugacccu cggagccagg aaacugaaga aacuuggcaa ccugaaauug     1920

caagaagagg gggaggcauc uuccacuaca ucaccuaccg aagagacgac ccagaagcuc     1980

acagugaguc auaucgaagg auaugagugc cagccaauau uucugaaugu auuagaagcc     2040

aucgagcccg gcguggucug ugcuggucac gauaacaauc agccugacag cuucgcggcc     2100

cugcuaucgu cccucaacga gcugggggaa cggcaacuug ugcacguugu gaaaugggca     2160

aaggcuuugc cgggauuucg caaucugcau gucgacgauc agauggccgu gauucaguac     2220

ucuuggaugg gccucauggu auucgccaug gguuggagau cuuucacuaa cguuaauuca     2280

aggaugcugu acuuugcucc cgacuuagug uucaacgagu aucguaugca caaaagucgg     2340

auguacuccc agugcguccg aaugagacau cugucucaag aauuuggcug gcuucagauc     2400

accccacagg aguucuugug uaugaaggca cuccugcuau uuagcauuau cccuguggau     2460

gggcugaaga accagaaauu cuuugacgaa cucaggauga auuauauaaa ggagcuggau     2520

cgcauuaucg ccugcaaacg gaagaacccc acauccugcu caagaagguu cuaccaacuu     2580

acuaaauugc uggacagcgu ccagccaauu gcgcgcgagu uacaccaguu uaccuucgau     2640

cuccugauca agagucauau ggugucuguu gacuuuccug aaaugauggc ugagaucauu     2700

uccgugcaag uacccaagau acuuagcgga aaagucaagc caaucuauuu ccacacacag     2760

uga                                                                   2763


<210>  480
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ANDR__Homo_sapiens__EAX05380

<400>  480
auggaggugc agcugggccu gggcagagug uaccccagac cccccagcaa gaccuacaga       60

ggcgccuucc agaaccuguu ccagagcgug agagagguga uccagaaccc cggccccaga      120

caccccgagg ccgccagcgc cgcccccccc ggcgccagcc ugcugcugcu gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      240

gagaccagcc ccagacagca gcagcagcag cagggcgagg acggcagccc ccaggcccac      300

agaagaggcc ccaccggcua ccuggugcug gacgaggagc agcagcccag ccagccccag      360

agcgcccugg agugccaccc cgagagaggc ugcgugcccg agcccggcgc cgccguggcc      420

gccagcaagg gccugcccca gcagcugccc gccccccccg acgaggacga cagcgccgcc      480

cccagcaccc ugagccugcu gggccccacc uuccccggcc ugagcagcug cagcgccgac      540

cugaaggaca uccugagcga ggccagcacc augcagcugc ugcagcagca gcagcaggag      600

gccgugagcg agggcagcag cagcggcaga gccagagagg ccagcggcgc ccccaccagc      660

agcaaggaca acuaccuggg cggcaccagc accaucagcg acaacgccaa ggagcugugc      720

aaggccguga gcgugagcau gggccugggc guggaggccc uggagcaccu gagccccggc      780

gagcagcuga gaggcgacug cauguacgcc ccccugcugg gcgugccccc cgccgugaga      840

cccacccccu gcgccccccu ggccgagugc aagggcagcc ugcuggacga cagcgccggc      900

aagagcaccg aggacaccgc cgaguacagc cccuucaagg gcggcuacac caagggccug      960

gagggcgaga gccugggcug cagcggcagc gccgccgccg gcagcagcgg cacccuggag     1020

cugcccagca cccugagccu guacaagagc ggcgcccugg acgaggccgc cgccuaccag     1080

agcagagacu acuacaacuu cccccuggcc cuggccggcc cccccccccc cccccccccc     1140

ccccaccccc acgccagaau caagcuggag aacccccugg acuacggcag cgccugggcc     1200

gccgccgccg cccagugcag auacggcgac cuggccagcc ugcacggcgc cggcgccgcc     1260

ggccccggca gcggcagccc cagcgccgcc gccagcagca gcuggcacac ccuguucacc     1320

gccgaggagg gccagcugua cggccccugc ggcggcggcg gcggcggcgg cggcggcggc     1380

ggcggcggcg gcggcggcgg cggcggcggc ggcggcggcg aggccggcgc cguggccccc     1440

uacggcuaca ccagaccccc ccagggccug gccggccagg agagcgacuu caccgccccc     1500

gacguguggu accccggcgg cauggugagc agagugcccu accccagccc caccugcgug     1560

aagagcgaga ugggccccug gauggacagc uacagcggcc ccuacggcga caugagacug     1620

gagaccgcca gagaccacgu gcugcccauc gacuacuacu ucccccccca gaagaccugc     1680

cugaucugcg gcgacgaggc cagcggcugc cacuacggcg cccugaccug cggcagcugc     1740

aagguguucu ucaagagagc cgccgagggc aagcagaagu accugugcgc cagcagaaac     1800

gacugcacca ucgacaaguu cagaagaaag aacugcccca gcugcagacu gagaaagugc     1860

uacgaggccg gcaugacccu gggcgccaga aagcugaaga agcugggcaa ccugaagcug     1920

caggaggagg gcgaggccag cagcaccacc agccccaccg aggagaccac ccagaagcug     1980

accgugagcc acaucgaggg cuacgagugc cagcccaucu uccugaacgu gcuggaggcc     2040

aucgagcccg gcguggugug cgccggccac gacaacaacc agcccgacag cuucgccgcc     2100

cugcugagca gccugaacga gcugggcgag agacagcugg ugcacguggu gaagugggcc     2160

aaggcccugc ccggcuucag aaaccugcac guggacgacc agauggccgu gauccaguac     2220

agcuggaugg gccugauggu guucgccaug ggcuggagaa gcuucaccaa cgugaacagc     2280

agaaugcugu acuucgcccc cgaccuggug uucaacgagu acagaaugca caagagcaga     2340

auguacagcc agugcgugag aaugagacac cugagccagg aguucggcug gcugcagauc     2400

accccccagg aguuccugug caugaaggcc cugcugcugu ucagcaucau ccccguggac     2460

ggccugaaga accagaaguu cuucgacgag cugagaauga acuacaucaa ggagcuggac     2520

agaaucaucg ccugcaagag aaagaacccc accagcugca gcagaagauu cuaccagcug     2580

accaagcugc uggacagcgu gcagcccauc gccagagagc ugcaccaguu caccuucgac     2640

cugcugauca agagccacau ggugagcgug gacuuccccg agaugauggc cgagaucauc     2700

agcgugcagg ugcccaagau ccugagcggc aaggugaagc ccaucuacuu ccacacccag     2760

uga                                                                   2763


<210>  481
<211>  2763
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ANDR__Homo_sapiens__EAX05380

<400>  481
auggaggugc agcugggccu cgggagaguc uacccccggc cuccgagcaa gaccuaucgc       60

ggagccuucc aaaaccuguu ucaguccguu agagaaguga uccagaaucc cggcccucgg      120

caccccgagg cugccucugc ggcuccuccc ggggccagcc uucugcuccu gcagcaacag      180

cagcagcaac agcagcagca acagcagcaa cagcagcagc aacagcagca gcaacagcag      240

gaaacauccc cucgccagca acagcagcag caaggagagg acggcucucc gcaggcccau      300

agacgggggc ccacgggaua ccuugugcug gaugaggaac agcaaccuag ccagccccag      360

uccgcucucg agugccaccc ugaacgcggc uguguccccg agccgggcgc cgcuguggcc      420

gcgucuaaag ggcugccuca gcaacugccc gccccucccg acgaagauga cagcgcugcc      480

cccuccaccc ucagccugcu uggaccuaca uucccgggcc ugucuuccug cagcgcugau      540

cucaaggaca uucugucuga ggccuccacc augcagcuuc ugcagcagca acagcaggag      600

gcgguuagcg aagggucuuc cagcggcaga gcccgggagg cuuccggagc ccccacaucu      660

agcaaagaua acuaucucgg gggaaccucc acaaucagcg acaaugcuaa ggaacugugu      720

aaagccgugu cugucuccau gggccugggc guggaggccc ucgaacaucu gagcccuggg      780

gagcagcuuc gcggagauug cauguacgcu ccccugcucg gcguuccucc cgcggugaga      840

ccgaccccuu gugcuccccu ggcugagugc aaggggucuc uucuggacga uagcgccgga      900

aaguccacgg aagacaccgc cgaguauucu ccuuuuaaag gcggguacac aaagggacuc      960

gaaggcgaga gccugggcug uuccgggagc gcugccgcgg gaucuuccgg cacccuggaa     1020

cuccccagca cacugucucu uuauaaaucc ggggcucugg augaggccgc cgcuuaccaa     1080

agccgggacu acuauaacuu cccucucgcc cuggcuggac ccccgccucc cccucccccg     1140

ccccacccuc augcccgcau uaaacuugag aauccccugg acuacggcuc cgcgugggcc     1200

gcugccgcug cccagugcag auauggggau cucgcgucuc ugcacggcgc cggagcugcc     1260

ggcccuggga gcggaucccc cucugcugcc gccagcucca gcuggcacac ccuguuuacg     1320

gcugaagagg gccagcucua cgggccuugu ggaggcgggg gcggaggcgg gggaggcggg     1380

ggaggcgggg gcggaggcgg gggaggcggg ggaggcgggg aagcgggcgc cgucgcuccc     1440

uauggauaca cacggccgcc ucaaggccug gccgggcagg agucugacuu caccgccccc     1500

gauguguggu auccuggagg cauggugucc cgcguccccu acccgagccc uacaugcguu     1560

aaaucugaaa uggggcccug gauggacucc uacagcggac cuuauggcga uaugagacuu     1620

gagaccgcuc gggaccaugu gcugcccauc gauuacuauu uucccccuca gaagaccugu     1680

cucauuugcg gcgacgaggc cucugggugc cacuacggag cgcugacaug uggcagcugc     1740

aagguguucu uuaaaagagc ugccgaaggg aagcagaaau aucugugugc cucccgcaac     1800

gauugcacga ucgacaaguu ccggagaaag aauuguccga gcugccgccu ucggaagugu     1860

uacgaggcug gaaugacccu cggcgccaga aaacugaaga agcuggggaa ccucaaacug     1920

caagaagagg gagaggcguc uuccacaacc agccccacag aagagaccac gcagaaacuu     1980

acagucuccc auaucgaagg cuaugagugc cagccuauuu uucugaaugu gcucgaagcu     2040

aucgagcccg gcguugugug ugccgggcac gauaacaauc agccugacuc uuucgccgcu     2100

cugcugagcu cccuuaacga gcucggagaa cgccaacugg uccacguggu uaagugggcc     2160

aaggcucugc ccggcuuucg gaaucuccau guggacgauc agauggccgu cauucaguac     2220

ucuuggaugg ggcugauggu guucgcgaug ggauggcgca gcuucaccaa cgucaauucc     2280

agaaugcuuu acuuugcccc ugaccuggug uucaacgagu aucggaugca caaaucuaga     2340

auguacagcc agugcguucg caugcggcau cucucccaag aauuuggcug gcugcagauc     2400

accccgcagg aguuccugug uaugaaggcc cuucuccugu uuagcauuau ccccguggau     2460

gggcugaaga accagaaauu cuuugacgaa cucagaauga auuauauuaa ggagcuggau     2520

cggaucaucg ccugcaaacg caagaacccu acaucuugcu ccagacgguu cuaccaacuu     2580

accaaacugc ucgacagcgu ccagcccauu gcuagagagc ugcaccaguu uacauucgau     2640

cugcuuauca agucucauau gguguccguu gacuuuccug aaaugauggc cgagauuauc     2700

agcgugcaag uccccaagau ucucucugga aaagugaagc cgaucuauuu ccacacgcag     2760

uga                                                                   2763


<210>  482
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ART-4__Homo_sapiens__Q9ULX3

<400>  482

Met Ala Pro Val Glu His Val Val Ala Asp Ala Gly Ala Phe Leu Arg 
1               5                   10                  15      


His Ala Ala Leu Gln Asp Ile Gly Lys Asn Ile Tyr Thr Ile Arg Glu 
            20                  25                  30          


Val Val Thr Glu Ile Arg Asp Lys Ala Thr Arg Arg Arg Leu Ala Val 
        35                  40                  45              


Leu Pro Tyr Glu Leu Arg Phe Lys Glu Pro Leu Pro Glu Tyr Val Arg 
    50                  55                  60                  


Leu Val Thr Glu Phe Ser Lys Lys Thr Gly Asp Tyr Pro Ser Leu Ser 
65                  70                  75                  80  


Ala Thr Asp Ile Gln Val Leu Ala Leu Thr Tyr Gln Leu Glu Ala Glu 
                85                  90                  95      


Phe Val Gly Val Ser His Leu Lys Gln Glu Pro Gln Lys Val Lys Val 
            100                 105                 110         


Ser Ser Ser Ile Gln His Pro Glu Thr Pro Leu His Ile Ser Gly Phe 
        115                 120                 125             


His Leu Pro Tyr Lys Pro Lys Pro Pro Gln Glu Thr Glu Lys Gly His 
    130                 135                 140                 


Ser Ala Cys Glu Pro Glu Asn Leu Glu Phe Ser Ser Phe Met Phe Trp 
145                 150                 155                 160 


Arg Asn Pro Leu Pro Asn Ile Asp His Glu Leu Gln Glu Leu Leu Ile 
                165                 170                 175     


Asp Arg Gly Glu Asp Val Pro Ser Glu Glu Glu Glu Glu Glu Glu Asn 
            180                 185                 190         


Gly Phe Glu Asp Arg Lys Asp Asp Ser Asp Asp Asp Gly Gly Gly Trp 
        195                 200                 205             


Ile Thr Pro Ser Asn Ile Lys Gln Ile Gln Gln Glu Leu Glu Gln Cys 
    210                 215                 220                 


Asp Val Pro Glu Asp Val Arg Val Gly Cys Leu Thr Thr Asp Phe Ala 
225                 230                 235                 240 


Met Gln Asn Val Leu Leu Gln Met Gly Leu His Val Leu Ala Val Asn 
                245                 250                 255     


Gly Met Leu Ile Arg Glu Ala Arg Ser Tyr Ile Leu Arg Cys His Gly 
            260                 265                 270         


Cys Phe Lys Thr Thr Ser Asp Met Ser Arg Val Phe Cys Ser His Cys 
        275                 280                 285             


Gly Asn Lys Thr Leu Lys Lys Val Ser Val Thr Val Ser Asp Asp Gly 
    290                 295                 300                 


Thr Leu His Met His Phe Ser Arg Asn Pro Lys Val Leu Asn Pro Arg 
305                 310                 315                 320 


Gly Leu Arg Tyr Ser Leu Pro Thr Pro Lys Gly Gly Lys Tyr Ala Ile 
                325                 330                 335     


Asn Pro His Leu Thr Glu Asp Gln Arg Phe Pro Gln Leu Arg Leu Ser 
            340                 345                 350         


Gln Lys Ala Arg Gln Lys Thr Asn Val Phe Ala Pro Asp Tyr Ile Ala 
        355                 360                 365             


Gly Val Ser Pro Phe Val Glu Asn Asp Ile Ser Ser Arg Ser Ala Thr 
    370                 375                 380                 


Leu Gln Val Arg Asp Ser Thr Leu Gly Ala Gly Arg Arg Arg Leu Asn 
385                 390                 395                 400 


Pro Asn Ala Ser Arg Lys Lys Phe Val Lys Lys Arg 
                405                 410         


<210>  483
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ART-4__Homo_sapiens__AAH64630

<400>  483
auggcuccag uggagcacgu uguggcggau gcuggggcuu uccugcggca ugcggcucug       60

caggacaucg ggaagaacau uuacaccauc cgggaggugg ucacugagau ucgggacaag      120

gccacacgca ggcggcucgc uguccugccc uacgagcugc gguucaagga gcccuuaccg      180

gaauacgugc ggcuggugac ugaguuuuca aagaaaacag gagacuaccc cagccucucu      240

gccacggaca uccaagugcu ugcacucaca uaccaguugg aagcagaguu uguuggggug      300

ucucaccuaa aacaagaacc acagaagguu aaggugagcu caucgauuca gcacccagaa      360

acaccucugc acauuucugg uuuccaucug cccuacaagc cuaaaccccc acaagaaaca      420

gaaaaaggac acucagcuug ugagccugag aaccuggaau uuaguuccuu cauguucugg      480

agaaacccuu ugcccaacau cgaucaugaa cugcaggagc ugcugauuga cagaggugag      540

gacguuccaa gugaggagga ggaggaggaa gaaaacgggu uugaagacag aaaagaugac      600

agcgaugacg acgggggugg cuggauaacc cccaguaaca ucaagcagau ccagcaggag      660

cuggagcagu gugacguccc cgaggacgug cggguuggcu gccugaccac agacuucgcc      720

augcagaaug uucugcugca gauggggcug cacgugcugg cggugaacgg caugcugauu      780

cgugaggccc ggagcuacau cuugcgcugc cauggcuguu ucaagacaac gucugacaug      840

agccgagugu ucugcucaca cugugggaac aagacccuga agaaaguguc cgugaccguc      900

agcgacgacg gcacccugca caugcacuuc ucccgcaacc ccaaggugcu gaacccccgc      960

ggccuccggu acucgcuucc cacucccaaa gggggcaaau acgccaucaa cccccaucuc     1020

accgaggauc agcgcuuccc ucagcugcga cucucccaaa aggccaggca gaaaaccaac     1080

guguucgccc cugacuacau cgccggggug ucacccuuug ucgagaauga caucuccagc     1140

cgcucagcua cccugcaggu ccgggacagc accuugggag cugggcggag acgcuuaaau     1200

cccaacgcuu ccagaaagaa guuugugaag aaaagguga                            1239


<210>  484
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ART-4__Homo_sapiens__AAH64630

<400>  484
auggcccccg uggagcacgu cguggccgac gcgggcgccu uccugcgcca cgccgcccuc       60

caggacaucg ggaagaacau cuacaccauc cgggaggugg ucaccgagau ccgcgacaag      120

gccacgcggc gccggcuggc ggugcugccg uacgagcucc gcuucaagga gccccugccc      180

gaguacgugc ggcuggucac cgaguucagc aagaagaccg gcgacuaccc cucccucagc      240

gccaccgaca uccaggugcu ggcccugacg uaccagcucg aggccgaguu cguggggguc      300

ucccaccuga agcaggagcc gcagaaggug aaggugagcu ccagcaucca gcaccccgag      360

acgccccugc acaucuccgg cuuccaccuc cccuacaagc cgaagccgcc ccaggagacc      420

gagaaggggc acagcgcgug cgagcccgag aaccuggagu ucuccagcuu cauguucugg      480

cgcaaccccc ugcccaacau cgaccacgag cuccaggagc ugcugaucga ccggggcgag      540

gacguccccu ccgaggagga ggaggaggag gagaacggcu ucgaggaccg caaggacgac      600

agcgacgacg acgggggcgg guggaucacc cccuccaaca ucaagcagau ccagcaggag      660

cucgagcagu gcgacgugcc ggaggacgug cgggucggcu gccugaccac cgacuucgcc      720

augcagaacg ugcugcucca gauggggcug cacgugcugg ccgucaacgg caugcucauc      780

cgcgaggccc ggagcuacau ccugcgcugc cacggcugcu ucaagaccac cuccgacaug      840

agccgggugu ucugcuccca cugcgggaac aagacgcuga agaaggugag cgucaccgug      900

uccgacgacg gcacccucca caugcacuuc agccgcaacc ccaaggugcu gaacccccgg      960

gggcugcgcu acagccuccc caccccgaag ggcggcaagu acgccaucaa cccccaccug     1020

acggaggacc agcgguuccc ccagcugcgc cucucccaga aggcgcggca gaagaccaac     1080

gucuucgccc ccgacuacau cgccggggug agcccguucg ucgagaacga caucuccagc     1140

cgcuccgcca cccuccaggu gcgcgacagc acccugggcg ccgggcggcg ccggcugaac     1200

cccaacgcgu cccgcaagaa guucgugaag aagcgguga                            1239


<210>  485
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ART-4__Homo_sapiens__AAH64630

<400>  485
auggcccccg ucgagcacgu cgucgccgac gccggcgccu uccuccgcca cgccgcccuc       60

caggacaucg gcaagaacau cuacaccauc cgcgaggucg ucaccgagau ccgcgacaag      120

gccacccgcc gccgccucgc cguccucccc uacgagcucc gcuucaagga gccccucccc      180

gaguacgucc gccucgucac cgaguucucc aagaagaccg gcgacuaccc cucccucucc      240

gccaccgaca uccagguccu cgcccucacc uaccagcucg aggccgaguu cgucggcguc      300

ucccaccuca agcaggagcc ccagaagguc aaggucuccu ccuccaucca gcaccccgag      360

accccccucc acaucuccgg cuuccaccuc cccuacaagc ccaagccccc ccaggagacc      420

gagaagggcc acuccgccug cgagcccgag aaccucgagu ucuccuccuu cauguucugg      480

cgcaaccccc uccccaacau cgaccacgag cuccaggagc uccucaucga ccgcggcgag      540

gacguccccu ccgaggagga ggaggaggag gagaacggcu ucgaggaccg caaggacgac      600

uccgacgacg acggcggcgg cuggaucacc cccuccaaca ucaagcagau ccagcaggag      660

cucgagcagu gcgacguccc cgaggacguc cgcgucggcu gccucaccac cgacuucgcc      720

augcagaacg uccuccucca gaugggccuc cacguccucg ccgucaacgg caugcucauc      780

cgcgaggccc gcuccuacau ccuccgcugc cacggcugcu ucaagaccac cuccgacaug      840

ucccgcgucu ucugcuccca cugcggcaac aagacccuca agaaggucuc cgucaccguc      900

uccgacgacg gcacccucca caugcacuuc ucccgcaacc ccaagguccu caacccccgc      960

ggccuccgcu acucccuccc cacccccaag ggcggcaagu acgccaucaa cccccaccuc     1020

accgaggacc agcgcuuccc ccagcuccgc cucucccaga aggcccgcca gaagaccaac     1080

gucuucgccc ccgacuacau cgccggcguc ucccccuucg ucgagaacga caucuccucc     1140

cgcuccgcca cccuccaggu ccgcgacucc acccucggcg ccggccgccg ccgccucaac     1200

cccaacgccu cccgcaagaa guucgucaag aagcgcuga                            1239


<210>  486
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ART-4__Homo_sapiens__AAH64630

<400>  486
auggcccccg uggagcacgu cguugcugac gcaggcgccu uccugagaca ugcggcucuc       60

caggauaucg ggaagaacau uuacaccaua agggaagugg uaacagagau ccgggacaaa      120

gccacucgcc gacgucuugc agugcugccu uaugaauuga gauuuaagga gccauuaccg      180

gaauacguca ggcuggugac ggaguucagc aaaaagaccg gagauuaucc cucccuaucu      240

gccacagaca uucaaguucu cgcucugacu uaccagcuug aggcagaauu uguggguguc      300

ucacaccuga aacaggagcc ucagaaggug aagguaagua gcuccaucca acauccagaa      360

acccccuugc acauuucugg cuuccaucuc ccuuauaaac caaagccccc ucaggagaca      420

gagaaagggc acucggccug cgaaccagag aaucuggaau uuagcucauu cauguuuugg      480

cggaacccgc ugcccaauau cgaucacgag cuccaggaau uacugauaga ccgcggagag      540

gauguuccua gugaggaaga ggaagaggaa gagaacggcu ucgaggacag aaaggaugac      600

uccgaugacg augguggggg auggaucacc ccaucuaaua uuaaacagau ccaacaggaa      660

cuugagcagu gugacgugcc cgaagacguc agggugggcu gcuugacuac agauuuugcu      720

augcagaacg ugcugcuaca aaugggccuc cauguccugg ccguuaaugg gaugcuuauu      780

cgggaggcgc gcagcuacau ccugcgaugu cacggaugcu ucaagaccac guccgacaug      840

ucaagagugu uuuguaguca uugcgguaac aagacuuuga aaaagguaag cgugaccguc      900

ucugaugacg gcacacucca caugcacuuc uccaggaauc cuaaagugcu gaacccacgg      960

ggguuacguu auucacugcc cacuccgaag ggaggcaaau acgcaauaaa uccucaucuc     1020

accgaagauc agcgcuuucc ccagcuuaga cugagccaaa aggccaggca gaaaacaaac     1080

guuuucgcuc cagacuacau ugccggugug aguccuuucg ucgagaauga uaucucuucc     1140

cggagcgcaa ccuugcaggu acgagacucg acgcuagggg cuggacgcag aaggcugaac     1200

cccaaugccu cucggaagaa guuugugaaa aagcgcuga                            1239


<210>  487
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ART-4__Homo_sapiens__AAH64630

<400>  487
auggcccccg uggagcacgu gguggccgac gccggcgccu uccugagaca cgccgcccug       60

caggacaucg gcaagaacau cuacaccauc agagaggugg ugaccgagau cagagacaag      120

gccaccagaa gaagacuggc cgugcugccc uacgagcuga gauucaagga gccccugccc      180

gaguacguga gacuggugac cgaguucagc aagaagaccg gcgacuaccc cagccugagc      240

gccaccgaca uccaggugcu ggcccugacc uaccagcugg aggccgaguu cgugggcgug      300

agccaccuga agcaggagcc ccagaaggug aaggugagca gcagcaucca gcaccccgag      360

accccccugc acaucagcgg cuuccaccug cccuacaagc ccaagccccc ccaggagacc      420

gagaagggcc acagcgccug cgagcccgag aaccuggagu ucagcagcuu cauguucugg      480

agaaaccccc ugcccaacau cgaccacgag cugcaggagc ugcugaucga cagaggcgag      540

gacgugccca gcgaggagga ggaggaggag gagaacggcu ucgaggacag aaaggacgac      600

agcgacgacg acggcggcgg cuggaucacc cccagcaaca ucaagcagau ccagcaggag      660

cuggagcagu gcgacgugcc cgaggacgug agagugggcu gccugaccac cgacuucgcc      720

augcagaacg ugcugcugca gaugggccug cacgugcugg ccgugaacgg caugcugauc      780

agagaggcca gaagcuacau ccugagaugc cacggcugcu ucaagaccac cagcgacaug      840

agcagagugu ucugcagcca cugcggcaac aagacccuga agaaggugag cgugaccgug      900

agcgacgacg gcacccugca caugcacuuc agcagaaacc ccaaggugcu gaaccccaga      960

ggccugagau acagccugcc cacccccaag ggcggcaagu acgccaucaa cccccaccug     1020

accgaggacc agagauuccc ccagcugaga cugagccaga aggccagaca gaagaccaac     1080

guguucgccc ccgacuacau cgccggcgug agccccuucg uggagaacga caucagcagc     1140

agaagcgcca cccugcaggu gagagacagc acccugggcg ccggcagaag aagacugaac     1200

cccaacgcca gcagaaagaa guucgugaag aagagauga                            1239


<210>  488
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ART-4__Homo_sapiens__AAH64630

<400>  488
auggcccccg uggagcacgu cguugcugac gccggcgcgu uccugagaca ugcugcccuc       60

caggauaucg ggaagaacau uuacaccauc cgggaagugg ugacagagau ucgcgacaaa      120

gccacgagac ggcgccuggc uguccuuccu uaugaacuga gauuuaagga gccgcucccc      180

gaauacgugc ggcugguuac cgaguucagc aaaaagacag gagauuaucc uucccuuucu      240

gccaccgaca uccaagugcu ggcucucaca uaccagcugg aggccgaauu ugucggcgug      300

agccaccuga aacaggagcc ccagaagguu aagguguccu cuagcauuca acauccugaa      360

acaccccucc acaucuccgg guuccaucug ccuuauaaac cgaagccccc ucaggagacc      420

gagaaaggac acucugcgug cgaacccgag aaucuugaau uuagcuccuu cauguuuugg      480

cgcaacccuc ugcccaauau cgaucacgag cuccaggaac ugcuuauuga cagaggcgag      540

gaugucccga gcgaggaaga ggaagaggaa gagaacgggu ucgaggaccg gaaggaugac      600

ucugaugacg auggaggcgg cuggaucacc ccuuccaaua uuaaacagau ccaacaggaa      660

cuggagcagu gugacgugcc cgaagacgug cgcgucgggu gccucacgac cgauuuugcc      720

augcagaacg uucugcugca aaugggacuc caugugcugg cugugaaugg caugcuuauu      780

agagaggccc ggagcuacau ccugcgcugu cacgggugcu ucaagacaac cucugacaug      840

uccagagucu uuuguagcca uugcggaaac aagacacuca aaaagguguc uguuaccgug      900

uccgaugacg gcacgcugca caugcacuuc agccggaauc cuaaaguccu uaacccccgc      960

gggcugagau auucccuccc cacaccuaag ggaggcaaau acgcuauuaa uccgcaucug     1020

accgaagauc agcgguuucc ccagcugaga cucucucaaa aggcccgcca gaaaacaaac     1080

guguucgcgc cugacuacau cgccggcguu agccccuucg uggagaauga uaucuccagc     1140

cggucugcua cccugcaggu cagagacucc acccuugggg ccggacgccg gagacugaac     1200

ccuaaugcua gccgcaagaa guuugugaaa aagcgguga                            1239


<210>  489
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ARTC1/m__Homo_sapiens__P52961

<400>  489

Met Gln Met Pro Ala Met Met Ser Leu Leu Leu Val Ser Val Gly Leu 
1               5                   10                  15      


Met Glu Ala Leu Gln Ala Gln Ser His Pro Ile Thr Arg Arg Asp Leu 
            20                  25                  30          


Phe Ser Gln Glu Ile Gln Leu Asp Met Ala Leu Ala Ser Phe Asp Asp 
        35                  40                  45              


Gln Tyr Ala Gly Cys Ala Ala Ala Met Thr Ala Ala Leu Pro Asp Leu 
    50                  55                  60                  


Asn His Thr Glu Phe Gln Ala Asn Gln Val Tyr Ala Asp Ser Trp Thr 
65                  70                  75                  80  


Leu Ala Ser Ser Gln Trp Gln Glu Arg Gln Ala Arg Trp Pro Glu Trp 
                85                  90                  95      


Ser Leu Ser Pro Thr Arg Pro Ser Pro Pro Pro Leu Gly Phe Arg Asp 
            100                 105                 110         


Glu His Gly Val Ala Leu Leu Ala Tyr Thr Ala Asn Ser Pro Leu His 
        115                 120                 125             


Lys Glu Phe Asn Ala Ala Val Arg Glu Ala Gly Arg Ser Arg Ala His 
    130                 135                 140                 


Tyr Leu His His Phe Ser Phe Lys Thr Leu His Phe Leu Leu Thr Glu 
145                 150                 155                 160 


Ala Leu Gln Leu Leu Gly Ser Gly Gln Arg Pro Pro Arg Cys His Gln 
                165                 170                 175     


Val Phe Arg Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro Arg 
            180                 185                 190         


Ala Thr Val Arg Leu Gly Gly Phe Ala Ser Ala Ser Leu Lys His Val 
        195                 200                 205             


Ala Ala Gln Gln Phe Gly Glu Asp Thr Phe Phe Gly Ile Trp Thr Cys 
    210                 215                 220                 


Leu Gly Ala Pro Ile Lys Gly Tyr Ser Phe Phe Pro Gly Glu Glu Glu 
225                 230                 235                 240 


Val Leu Ile Pro Pro Phe Glu Thr Phe Gln Val Ile Asn Ala Ser Arg 
                245                 250                 255     


Leu Ala Gln Gly Pro Ala Arg Ile Tyr Leu Arg Ala Leu Gly Lys His 
            260                 265                 270         


Ser Thr Tyr Asn Cys Glu Tyr Ile Lys Asp Lys Lys Cys Lys Ser Gly 
        275                 280                 285             


Pro Cys His Leu Asp Asn Ser Ala Met Gly Gln Ser Pro Leu Ser Ala 
    290                 295                 300                 


Val Trp Ser Leu Leu Leu Leu Leu Trp Phe Leu Val Val Arg Ala Phe 
305                 310                 315                 320 


Pro Asp Gly Pro Gly Leu Leu 
                325         


<210>  490
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ARTC1/m__Homo_sapiens__AAH69102

<400>  490
augcagaugc cugcuaugau gucucugcuu cuugugucug ugggccucau ggaagcacuu       60

caggcccaga gccaccccau cacacgacga gaccucuucu cucaagagau ucagcuggac      120

auggcccugg ccuccuuuga ugaccaguac gcuggcugug cugcugccau gacagcugcu      180

cucccggauc ucaaccacac ggaguuccag gccaaccagg uguaugcaga cagcuggaca      240

cuggcaagca gccaauggca ggagcgucag gccagguggc cagaguggag ucucagcccc      300

acccguccau ccccgccacc ccugggcuuc cgcgaugagc augggguggc ccuccuggcc      360

uacacagcca acagcccccu gcacaaggag uucaaugcag ccgugcguga ggcgggccgc      420

ucccgggccc acuaccucca ccacuucucc uucaagacac uccauuuccu gcugacugag      480

gcccugcagc uccugggcag cggccagcgu ccaccccggu gccaccaggu guuccgaggu      540

gugcacggcc ugcgcuuccg gccagcaggg ccccgggcca ccgugaggcu ggggggcuuu      600

gcuucugccu cccugaagca uguugcagcc cagcaguuug gugaggacac cuucuucggc      660

aucuggaccu gccuuggggc cccuaucaag ggcuacuccu ucuucccugg agaggaagag      720

gugcugaucc cccccuuuga gaccuuccaa gugaucaaug ccagcagacu ggcccagggc      780

cccgcccgca ucuaccuccg agcccugggc aagcacagca ccuacaacug cgaguacauc      840

aaagacaaga agugcaaguc ugggccuugc caucuggaua auucagccau gggucagagc      900

ccccucucug cagucugguc uuugcugcug cugcucuggu uccucguggu gagggccuuu      960

ccagaugguc caggccuccu uuga                                             984


<210>  491
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ARTC1/m__Homo_sapiens__AAH69102

<400>  491
augcagaugc ccgccaugau gagccugcuc cugguguccg ucggccugau ggaggcccuc       60

caggcgcaga gccaccccau cacccgccgg gaccuguucu cccaggagau ccagcuggac      120

auggcccucg ccagcuucga cgaccaguac gccgggugcg ccgcggccau gaccgccgcc      180

cugcccgacc ugaaccacac ggaguuccag gcgaaccagg uguacgccga cuccuggacc      240

cucgccagcu cccaguggca ggagcgccag gcccgguggc ccgaguggag ccuguccccc      300

acccgcccgu ccccgccgcc ccugggcuuc cgggacgagc acgggguggc ccuccuggcg      360

uacaccgcca acagcccccu gcacaaggag uucaacgccg ccguccgcga ggccggccgg      420

agccgcgcgc acuaccucca ccacuucucc uucaagacgc ugcacuuccu gcucaccgag      480

gcccugcagc ugcucgggag cggccagcgg ccgccccgcu gccaccaggu guuccggggc      540

gugcacgggc ugcgcuuccg gcccgccggc ccccgcgcca ccguccggcu cgggggcuuc      600

gccuccgcga gccugaagca cguggccgcc cagcaguucg gggaggacac cuucuucggc      660

aucuggacgu gccugggcgc ccccaucaag ggguacuccu ucuuccccgg cgaggaggag      720

gugcugaucc cgcccuucga gaccuuccag gucaucaacg ccagccgccu cgcgcagggg      780

cccgcccgga ucuaccugcg cgcccugggc aagcacucca ccuacaacug cgaguacauc      840

aaggacaaga agugcaagag cggccccugc caccucgaca acagcgccau ggggcagucc      900

ccgcugagcg cggugugguc ccugcuccug cugcucuggu uccugguggu ccgggccuuc      960

cccgacggcc ccgggcugcu cuga                                             984


<210>  492
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ARTC1/m__Homo_sapiens__AAH69102

<400>  492
augcagaugc ccgccaugau gucccuccuc cucgucuccg ucggccucau ggaggcccuc       60

caggcccagu cccaccccau cacccgccgc gaccucuucu cccaggagau ccagcucgac      120

auggcccucg ccuccuucga cgaccaguac gccggcugcg ccgccgccau gaccgccgcc      180

cuccccgacc ucaaccacac cgaguuccag gccaaccagg ucuacgccga cuccuggacc      240

cucgccuccu cccaguggca ggagcgccag gcccgcuggc ccgagugguc ccucuccccc      300

acccgccccu cccccccccc ccucggcuuc cgcgacgagc acggcgucgc ccuccucgcc      360

uacaccgcca acuccccccu ccacaaggag uucaacgccg ccguccgcga ggccggccgc      420

ucccgcgccc acuaccucca ccacuucucc uucaagaccc uccacuuccu ccucaccgag      480

gcccuccagc uccucggcuc cggccagcgc cccccccgcu gccaccaggu cuuccgcggc      540

guccacggcc uccgcuuccg ccccgccggc ccccgcgcca ccguccgccu cggcggcuuc      600

gccuccgccu cccucaagca cgucgccgcc cagcaguucg gcgaggacac cuucuucggc      660

aucuggaccu gccucggcgc ccccaucaag ggcuacuccu ucuuccccgg cgaggaggag      720

guccucaucc cccccuucga gaccuuccag gucaucaacg ccucccgccu cgcccagggc      780

cccgcccgca ucuaccuccg cgcccucggc aagcacucca ccuacaacug cgaguacauc      840

aaggacaaga agugcaaguc cggccccugc caccucgaca acuccgccau gggccagucc      900

ccccucuccg ccgucugguc ccuccuccuc cuccucuggu uccucgucgu ccgcgccuuc      960

cccgacggcc ccggccuccu cuga                                             984


<210>  493
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ARTC1/m__Homo_sapiens__AAH69102

<400>  493
augcagaugc ccgccaugau gagccugcuc cuuguguccg ucggccugau ggaggcuuug       60

caagcacagu cucacccuau caccagaagg gacuuauucu cacaggaaau ucagcuggau      120

auggcccuag cgaguuuuga cgaucaauac gcugggugcg ccgcagccau gacagcugca      180

cucccagacc ugaaccauac ugaguuccag gccaaucagg uuuaugcuga uagcuggacg      240

cuugccuccu cucaguggca agaacggcag gcgcgcuggc cggagugguc gcugucaccc      300

acccgaccua gcccaccccc uuugggauuu cgugacgaac acgguguggc acuccuggcc      360

uacacagcua acaguccacu gcauaaggag uucaaugccg caguaagaga ggcuggcagg      420

ucccgggccc acuaucucca ucacuuuucu uucaaaacuu uacacuuucu gcuuaccgaa      480

gcguugcagc ugcuagggag cggacagaga cccccucgcu gucaucaagu guucaggggc      540

guccacgguc uccgguuucg cccagccggg ccgcgagcaa cagugagacu gggaggcuuc      600

gcuuccgccu cacuuaagca uguugcugcc cagcaguuug gcgaggauac cuucuuuggg      660

auauggacuu gccugggagc acccaucaaa gguuacaguu ucuucccugg cgaagaggag      720

guguugauuc cacccuuuga aacauuccaa gucaucaacg ccagcaggcu cgcucagggg      780

ccugcgcgga uuuaucugcg ugcauuagga aagcacucua ccuacaauug ugaguauauc      840

aaagacaaga agugcaaauc cggcccaugu caccuggaua acucagccau gggucagagc      900

ccccucagug cugugugguc ucuucuguug cuacuguggu uucucguagu ucgcgccuuc      960

ccggacgggc cuggacugcu uuga                                             984


<210>  494
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ARTC1/m__Homo_sapiens__AAH69102

<400>  494
augcagaugc ccgccaugau gagccugcug cuggugagcg ugggccugau ggaggcccug       60

caggcccaga gccaccccau caccagaaga gaccuguuca gccaggagau ccagcuggac      120

auggcccugg ccagcuucga cgaccaguac gccggcugcg ccgccgccau gaccgccgcc      180

cugcccgacc ugaaccacac cgaguuccag gccaaccagg uguacgccga cagcuggacc      240

cuggccagca gccaguggca ggagagacag gccagauggc ccgaguggag ccugagcccc      300

accagaccca gccccccccc ccugggcuuc agagacgagc acggcguggc ccugcuggcc      360

uacaccgcca acagcccccu gcacaaggag uucaacgccg ccgugagaga ggccggcaga      420

agcagagccc acuaccugca ccacuucagc uucaagaccc ugcacuuccu gcugaccgag      480

gcccugcagc ugcugggcag cggccagaga ccccccagau gccaccaggu guucagaggc      540

gugcacggcc ugagauucag acccgccggc cccagagcca ccgugagacu gggcggcuuc      600

gccagcgcca gccugaagca cguggccgcc cagcaguucg gcgaggacac cuucuucggc      660

aucuggaccu gccugggcgc ccccaucaag ggcuacagcu ucuuccccgg cgaggaggag      720

gugcugaucc cccccuucga gaccuuccag gugaucaacg ccagcagacu ggcccagggc      780

cccgccagaa ucuaccugag agcccugggc aagcacagca ccuacaacug cgaguacauc      840

aaggacaaga agugcaagag cggccccugc caccuggaca acagcgccau gggccagagc      900

ccccugagcg ccguguggag ccugcugcug cugcuguggu uccugguggu gagagccuuc      960

cccgacggcc ccggccugcu guga                                             984


<210>  495
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ARTC1/m__Homo_sapiens__AAH69102

<400>  495
augcagaugc ccgccaugau gagccugcuc cugguguccg ucggccuuau ggaggcucug       60

caagcccagu cucacccuau caccagacgg gaccucuuca gccaggaaau ucagcuggau      120

auggcgcuug cuuccuuuga cgaucaauac gccgggugcg ccgcugccau gacagcugcc      180

cugccggacc ucaaccauac ggaguuccag gcgaaucagg uuuaugccga uucuuggacc      240

cuggcuagcu cccaguggca agaacgccag gccagauggc ccgagugguc ucugagcccu      300

acacggcccu ccccuccccc ucucggauuu cgcgacgaac acggcguggc ucugcuugcc      360

uacaccgcga acagcccgcu gcauaaggag uucaaugccg cugugagaga ggccgggcgg      420

ucucgcgcuc acuaucucca ucacuuuucc uucaaaacac ugcacuuucu ucugaccgaa      480

gcccuccagc ugcugggaag cggccagaga cccccucggu gucaucaagu cuuccgcggg      540

gugcacggac ucagauuucg gcccgccggc ccucgcgcua caguuagacu gggcggguuc      600

gcgucugccu cccuuaagca uguggcugcc cagcaguuug gagaggauac cuucuuuggc      660

aucuggacgu gccugggggc ccccauuaaa ggauacagcu ucuucccggg cgaagaggag      720

guccucaucc cucccuuuga aaccuuccaa gugauuaacg cuucucggcu ggcccagggg      780

ccugcgcgca ucuaucuuag agcucuggga aagcacucca cauacaauug ugaguauauc      840

aaagacaaga agugcaaaag cggccccugu caccucgaua acuccgccau gggccagucu      900

ccccugagcg ccguuugguc ccugcuccug cuucuguggu uucucguggu ccgggcuuuc      960

ccugacgggc cgggacugcu uuga                                             984


<210>  496
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  AURKB__Homo_sapiens__Q96GD4

<400>  496

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210>  497
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  AURKB__Homo_sapiens__AAH09751

<400>  497
auggcccaga aggagaacuc cuaccccugg cccuacggcc gacagacggc uccaucuggc       60

cugagcaccc ugccccagcg aguccuccgg aaagagccug ucaccccauc ugcacuuguc      120

cucaugagcc gcuccaaugu ccagcccaca gcugccccug gccagaaggu gauggagaau      180

agcaguggga cacccgacau cuuaacgcgg cacuucacaa uugaugacuu ugagauuggg      240

cguccucugg gcaaaggcaa guuuggaaac guguacuugg cucgggagaa gaaaagccau      300

uucaucgugg cgcucaaggu ccucuucaag ucccagauag agaaggaggg cguggagcau      360

cagcugcgca gagagaucga aauccaggcc caccugcacc aucccaacau ccugcgucuc      420

uacaacuauu uuuaugaccg gaggaggauc uacuugauuc uagaguaugc cccccgcggg      480

gagcucuaca aggagcugca gaagagcugc acauuugacg agcagcgaac agccacgauc      540

auggaggagu uggcagaugc ucuaauguac ugccauggga agaaggugau ucacagagac      600

auaaagccag aaaaucugcu cuuagggcuc aagggagagc ugaagauugc ugacuucggc      660

uggucugugc augcgcccuc ccugaggagg aagacaaugu guggcacccu ggacuaccug      720

cccccagaga ugauugaggg gcgcaugcac aaugagaagg uggaucugug gugcauugga      780

gugcuuugcu augagcugcu gguggggaac ccacccuuug agagugcauc acacaacgag      840

accuaucgcc gcaucgucaa gguggaccua aaguuccccg cuuccgugcc caugggagcc      900

caggaccuca ucuccaaacu gcucaggcau aaccccucgg aacggcugcc ccuggcccag      960

gucucagccc acccuugggu ccgggccaac ucucggaggg ugcugccucc cucugcccuu     1020

caaucugucg ccuga                                                      1035


<210>  498
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       AURKB__Homo_sapiens__AAH09751

<400>  498
auggcccaga aggagaacag cuaccccugg cccuacggcc gccagaccgc ccccuccggg       60

cugagcaccc ucccccagcg ggugcugcgc aaggagcccg ucacgccguc cgcgcuggug      120

cucaugagcc gguccaacgu gcagcccacc gccgcccccg gccagaaggu cauggagaac      180

agcuccggga cccccgacau ccugacccgc cacuucacga ucgacgacuu cgagaucggc      240

cggccgcugg ggaagggcaa guucggcaac guguaccucg cccgcgagaa gaagucccac      300

uucaucgugg cccugaaggu ccuguucaag agccagaucg agaaggaggg gguggagcac      360

cagcuccggc gcgagaucga gauccaggcg caccuccacc accccaacau ccugcggcug      420

uacaacuacu ucuacgaccg ccggcgcauc uaccugaucc uggaguacgc gccccggggc      480

gagcucuaca aggagcugca gaaguccugc accuucgacg agcagcgcac cgccaccauc      540

auggaggagc uggccgacgc ccucauguac ugccacggga agaaggugau ccaccgggac      600

aucaagcccg agaaccugcu gcucggccug aagggggagc ugaagaucgc cgacuucggc      660

uggagcgucc acgccccgag ccuccgccgg aagacgaugu gcggcacccu ggacuaccug      720

ccgcccgaga ugaucgaggg gcgcaugcac aacgagaagg uggaccucug gugcaucggc      780

gugcugugcu acgagcugcu cgucgggaac ccgcccuucg aguccgccag ccacaacgag      840

accuaccggc gcaucgugaa gguggaccug aaguuccccg ccuccguccc caugggcgcg      900

caggaccuga ucagcaagcu ccugcggcac aaccccuccg agcgccugcc ccucgcccag      960

gugagcgccc accccugggu gcgcgccaac ucccggcgcg uccugccgcc cagcgcccug     1020

cagagcgugg cguga                                                      1035


<210>  499
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       AURKB__Homo_sapiens__AAH09751

<400>  499
auggcccaga aggagaacuc cuaccccugg cccuacggcc gccagaccgc ccccuccggc       60

cucuccaccc ucccccagcg cguccuccgc aaggagcccg ucacccccuc cgcccucguc      120

cucauguccc gcuccaacgu ccagcccacc gccgcccccg gccagaaggu cauggagaac      180

uccuccggca cccccgacau ccucacccgc cacuucacca ucgacgacuu cgagaucggc      240

cgcccccucg gcaagggcaa guucggcaac gucuaccucg cccgcgagaa gaagucccac      300

uucaucgucg cccucaaggu ccucuucaag ucccagaucg agaaggaggg cgucgagcac      360

cagcuccgcc gcgagaucga gauccaggcc caccuccacc accccaacau ccuccgccuc      420

uacaacuacu ucuacgaccg ccgccgcauc uaccucaucc ucgaguacgc cccccgcggc      480

gagcucuaca aggagcucca gaaguccugc accuucgacg agcagcgcac cgccaccauc      540

auggaggagc ucgccgacgc ccucauguac ugccacggca agaaggucau ccaccgcgac      600

aucaagcccg agaaccuccu ccucggccuc aagggcgagc ucaagaucgc cgacuucggc      660

ugguccgucc acgcccccuc ccuccgccgc aagaccaugu gcggcacccu cgacuaccuc      720

ccccccgaga ugaucgaggg ccgcaugcac aacgagaagg ucgaccucug gugcaucggc      780

guccucugcu acgagcuccu cgucggcaac ccccccuucg aguccgccuc ccacaacgag      840

accuaccgcc gcaucgucaa ggucgaccuc aaguuccccg ccuccguccc caugggcgcc      900

caggaccuca ucuccaagcu ccuccgccac aaccccuccg agcgccuccc ccucgcccag      960

gucuccgccc accccugggu ccgcgccaac ucccgccgcg uccucccccc cuccgcccuc     1020

caguccgucg ccuga                                                      1035


<210>  500
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       AURKB__Homo_sapiens__AAH09751

<400>  500
auggcccaga aggagaacag cuaccccugg ccuuauggca gacaaaccgc uccauccggg       60

cugucuacac ucccgcagag ggugcuucgg aaagaacccg ucacuccuuc agcacugguu      120

uugaugaguc gcagcaaugu gcagccaacg gccgcgcccg gacagaaggu aauggagaac      180

uccucuggua ccccugacau cuuaacacga cacuucacua uugaugacuu ugaaauaggc      240

cguccacugg ggaaaggaaa guucggcaau guguaccuag cuagagagaa aaagucgcau      300

uuuaucgucg cccucaaggu gcuguucaaa ucacaaauug aaaaggaggg uguugagcac      360

cagcuuaggc gggaaaucga gauucaggca caucugcacc aucccaacau cuugcgccuc      420

uauaauuacu uuuaugauag aaggcggaua uaccugaucc uggaauaugc cccucgcggg      480

gagcucuaca aagaguuaca gaaaagcugc accuucgacg aacaacgaac agcuaccauu      540

auggaggaac uggcagaugc ccuuauguac ugucacggaa agaaggugau ccacagagac      600

auuaagccag agaacuugcu gcuaggccuc aaaggcgaac ugaagaucgc ugauuuuggg      660

uggagugucc augccccguc ccuuaggcgg aaaacuaugu gcggaacacu ggacuauuug      720

cccccugaga ugauagaggg ucguaugcac aaugaaaagg uggaucucug guguauuggc      780

guacugugcu acgaguuacu gguugggaac ccacccuucg aaucugcgag ccauaaugag      840

accuaucgca gaaucgugaa agucgaccuc aaguuuccug cauccgugcc aaugggagcc      900

caggaucuua uuucaaaacu guugaggcac aaccccagug aacggcuacc gcuggcucag      960

gugagcgccc acccuugggu ccgagcaaau ucucgcagag uucugccccc auccgcucuc     1020

cagucagugg ccuga                                                      1035


<210>  501
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       AURKB__Homo_sapiens__AAH09751

<400>  501
auggcccaga aggagaacag cuaccccugg cccuacggca gacagaccgc ccccagcggc       60

cugagcaccc ugccccagag agugcugaga aaggagcccg ugacccccag cgcccuggug      120

cugaugagca gaagcaacgu gcagcccacc gccgcccccg gccagaaggu gauggagaac      180

agcagcggca cccccgacau ccugaccaga cacuucacca ucgacgacuu cgagaucggc      240

agaccccugg gcaagggcaa guucggcaac guguaccugg ccagagagaa gaagagccac      300

uucaucgugg cccugaaggu gcuguucaag agccagaucg agaaggaggg cguggagcac      360

cagcugagaa gagagaucga gauccaggcc caccugcacc accccaacau ccugagacug      420

uacaacuacu ucuacgacag aagaagaauc uaccugaucc uggaguacgc ccccagaggc      480

gagcuguaca aggagcugca gaagagcugc accuucgacg agcagagaac cgccaccauc      540

auggaggagc uggccgacgc ccugauguac ugccacggca agaaggugau ccacagagac      600

aucaagcccg agaaccugcu gcugggccug aagggcgagc ugaagaucgc cgacuucggc      660

uggagcgugc acgcccccag ccugagaaga aagaccaugu gcggcacccu ggacuaccug      720

ccccccgaga ugaucgaggg cagaaugcac aacgagaagg uggaccugug gugcaucggc      780

gugcugugcu acgagcugcu ggugggcaac ccccccuucg agagcgccag ccacaacgag      840

accuacagaa gaaucgugaa gguggaccug aaguuccccg ccagcgugcc caugggcgcc      900

caggaccuga ucagcaagcu gcugagacac aaccccagcg agagacugcc ccuggcccag      960

gugagcgccc accccugggu gagagccaac agcagaagag ugcugccccc cagcgcccug     1020

cagagcgugg ccuga                                                      1035


<210>  502
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       AURKB__Homo_sapiens__AAH09751

<400>  502
auggcccaga aggagaacag cuaccccugg ccuuauggca gacaaaccgc uccguccggg       60

cugucuacac ucccccagcg ggugcugcgc aaagaaccug ucacgcccag cgcccuuguu      120

cugaugucca gaucuaaugu gcagccuacc gcggcucccg gacagaaggu gauggagaac      180

agcuccggca caccugacau ccucacccgg cacuucacaa uugaugacuu ugaaaucggg      240

cgcccgcugg gaaaaggcaa guucgggaau gucuaccuug ccagagagaa aaagucucau      300

uuuauugugg cccugaaggu ucucuucaaa agccaaaucg aaaaggaggg aguggagcac      360

cagcugcggc gcgaaauuga gauccaggcu caucugcacc aucccaacau ccucagacug      420

uauaauuacu uuuaugaucg gcgcagaauu uaccuuaucc uggaauaugc cccucggggc      480

gagcucuaca aagagcugca gaaguccugc accuucgacg aacaacgcac agcuaccauu      540

auggaggaac uugccgaugc gcugauguac ugucacggca aaaaggucau ccacagagac      600

auuaagcccg agaaccuccu gcuggggcuc aaaggagaac ugaagaucgc cgauuuuggc      660

uggagcgugc augcuccuuc ucuucggcgc aaaacgaugu gcgggacccu ggacuaucug      720

cccccggaga ugauugaggg aagaaugcac aaugaaaagg uugaucucug guguaucggc      780

gugcuuugcu acgagcugcu cgucgggaac ccucccuucg aauccgccag ccauaaugag      840

acauaucgga gaaucgugaa aguggaccug aaguuuccug cuucuguccc caugggagcc      900

caggaucuga uuuccaaacu ccugcgccac aaccccagcg aacggcuucc ucuggcgcag      960

guuucugccc acccgugggu gagagcuaau ucccgccggg ugcugccccc uagcgcccuc     1020

caguccgucg cuuga                                                      1035


<210>  503
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  B2MG__Homo_sapiens__P61769

<400>  503

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  504
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  B2MG__Homo_sapiens__AAD48083

<400>  504
augucucgcu ccguggccuu agcugugcuc gcgcuacucu cucuuucugg ccuggaggcu       60

auccagcgua cuccaaagau ucagguuuac ucacgucauc cagcagagaa uggaaaguca      120

aauuuccuga auugcuaugu gucuggguuu cauccauccg acauugaagu ugacuuacug      180

aagaauggag agagaauuga aaaaguggag cauucagacu ugucuuucag caaggacugg      240

ucuuucuauc ucuuguacua cacugaauuc acccccacug aaaaagauga guaugccugc      300

cgugugaacc augugacuuu gucacagccc aagauaguua agugggaucg agacauguaa      360


<210>  505
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       B2MG__Homo_sapiens__AAD48083

<400>  505
augagccgcu ccguggcccu ggccguccuc gcgcugcuga gccucuccgg ccuggaggcc       60

auccagcgga cccccaagau ccagguguac agccgccacc cggccgagaa cgggaagucc      120

aacuuccuga acugcuacgu gagcggcuuc caccccuccg acaucgaggu cgaccuccug      180

aagaacgggg agcggaucga gaagguggag cacagcgacc uguccuucag caaggacugg      240

uccuucuacc uccuguacua caccgaguuc acgcccaccg agaaggacga guacgccugc      300

cgcgugaacc acgucacccu gagccagccc aagaucguga agugggaccg ggacauguga      360


<210>  506
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       B2MG__Homo_sapiens__AAD48083

<400>  506
augucccgcu ccgucgcccu cgccguccuc gcccuccucu cccucuccgg ccucgaggcc       60

auccagcgca cccccaagau ccaggucuac ucccgccacc ccgccgagaa cggcaagucc      120

aacuuccuca acugcuacgu cuccggcuuc caccccuccg acaucgaggu cgaccuccuc      180

aagaacggcg agcgcaucga gaaggucgag cacuccgacc ucuccuucuc caaggacugg      240

uccuucuacc uccucuacua caccgaguuc acccccaccg agaaggacga guacgccugc      300

cgcgucaacc acgucacccu cucccagccc aagaucguca agugggaccg cgacauguga      360


<210>  507
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       B2MG__Homo_sapiens__AAD48083

<400>  507
augagcagau ccguggcccu ggcuguccuc gcacuucugu cuuugucagg cuuagaggcc       60

auccagagga cccccaagau ucaaguuuac agucggcacc cugcggaaaa cgggaaaagc      120

aauuuccuga acugcuaugu guccggauuu cauccaucug acauagaggu agaucuacuc      180

aagaauggug aacgcaucga gaaaguggaa cacucggacc ugucauucag caaggauugg      240

aguuuuuacc uucuguauua cacagaguuc acuccgacgg agaaagacga auaugcuugu      300

cgagucaacc augugaccuu gucccagccc aagauuguua agugggaucg ugacauguga      360


<210>  508
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       B2MG__Homo_sapiens__AAD48083

<400>  508
augagcagaa gcguggcccu ggccgugcug gcccugcuga gccugagcgg ccuggaggcc       60

auccagagaa cccccaagau ccagguguac agcagacacc ccgccgagaa cggcaagagc      120

aacuuccuga acugcuacgu gagcggcuuc caccccagcg acaucgaggu ggaccugcug      180

aagaacggcg agagaaucga gaagguggag cacagcgacc ugagcuucag caaggacugg      240

agcuucuacc ugcuguacua caccgaguuc acccccaccg agaaggacga guacgccugc      300

agagugaacc acgugacccu gagccagccc aagaucguga agugggacag agacauguga      360


<210>  509
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       B2MG__Homo_sapiens__AAD48083

<400>  509
augagcagau ccguggcccu ggcuguccuc gcccugcuuu cucugagcgg ccucgaggcg       60

auccagcgga cccccaagau ucaaguuuac ucccgccacc cugcugaaaa cgggaaaucu      120

aauuuccuga acugcuaugu gagcggauuu cauccguccg acaucgaggu ggaucuucug      180

aagaauggcg aaagaauuga gaaagucgaa cacucugacc ucagcuucuc caaggauugg      240

agcuuuuacc ugcuguauua cacagaguuc acgcccaccg agaaagacga auaugccugu      300

cgggugaacc auguuacacu cucucagccu aagaucguga agugggaucg cgacauguga      360


<210>  510
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  B3GN5__Homo_sapiens__Q9BYG0

<400>  510

Met Arg Met Leu Val Ser Gly Arg Arg Val Lys Lys Trp Gln Leu Ile 
1               5                   10                  15      


Ile Gln Leu Phe Ala Thr Cys Phe Leu Ala Ser Leu Met Phe Phe Trp 
            20                  25                  30          


Glu Pro Ile Asp Asn His Ile Val Ser His Met Lys Ser Tyr Ser Tyr 
        35                  40                  45              


Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu 
    50                  55                  60                  


Lys His Thr Ser Ala Gly Pro Arg Tyr Gln Tyr Leu Ile Asn His Lys 
65                  70                  75                  80  


Glu Lys Cys Gln Ala Gln Asp Val Leu Leu Leu Leu Phe Val Lys Thr 
                85                  90                  95      


Ala Pro Glu Asn Tyr Asp Arg Arg Ser Gly Ile Arg Arg Thr Trp Gly 
            100                 105                 110         


Asn Glu Asn Tyr Val Arg Ser Gln Leu Asn Ala Asn Ile Lys Thr Leu 
        115                 120                 125             


Phe Ala Leu Gly Thr Pro Asn Pro Leu Glu Gly Glu Glu Leu Gln Arg 
    130                 135                 140                 


Lys Leu Ala Trp Glu Asp Gln Arg Tyr Asn Asp Ile Ile Gln Gln Asp 
145                 150                 155                 160 


Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu Leu Met Gln Phe 
                165                 170                 175     


Ser Trp Ala Asn Thr Tyr Cys Pro His Ala Lys Phe Leu Met Thr Ala 
            180                 185                 190         


Asp Asp Asp Ile Phe Ile His Met Pro Asn Leu Ile Glu Tyr Leu Gln 
        195                 200                 205             


Ser Leu Glu Gln Ile Gly Val Gln Asp Phe Trp Ile Gly Arg Val His 
    210                 215                 220                 


Arg Gly Ala Pro Pro Ile Arg Asp Lys Ser Ser Lys Tyr Tyr Val Ser 
225                 230                 235                 240 


Tyr Glu Met Tyr Gln Trp Pro Ala Tyr Pro Asp Tyr Thr Ala Gly Ala 
                245                 250                 255     


Ala Tyr Val Ile Ser Gly Asp Val Ala Ala Lys Val Tyr Glu Ala Ser 
            260                 265                 270         


Gln Thr Leu Asn Ser Ser Leu Tyr Ile Asp Asp Val Phe Met Gly Leu 
        275                 280                 285             


Cys Ala Asn Lys Ile Gly Ile Val Pro Gln Asp His Val Phe Phe Ser 
    290                 295                 300                 


Gly Glu Gly Lys Thr Pro Tyr His Pro Cys Ile Tyr Glu Lys Met Met 
305                 310                 315                 320 


Thr Ser His Gly His Leu Glu Asp Leu Gln Asp Leu Trp Lys Asn Ala 
                325                 330                 335     


Thr Asp Pro Lys Val Lys Thr Ile Ser Lys Gly Phe Phe Gly Gln Ile 
            340                 345                 350         


Tyr Cys Arg Leu Met Lys Ile Ile Leu Leu Cys Lys Ile Ser Tyr Val 
        355                 360                 365             


Asp Thr Tyr Pro Cys Arg Ala Ala Phe Ile 
    370                 375             


<210>  511
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  B3GN5__Homo_sapiens__AAH28058

<400>  511
augagaaugu ugguuagugg cagaagaguc aaaaaauggc aguuaauuau ucaguuauuu       60

gcuacuuguu uuuuagcgag ccucauguuu uuuugggaac caaucgauaa ucacauugug      120

agccauauga agucauauuc uuacagauac cucauaaaua gcuaugacuu ugugaaugau      180

acccugucuc uuaagcacac cucagcgggg ccucgcuacc aauacuugau uaaccacaag      240

gaaaaguguc aagcucaaga cguccuccuu uuacuguuug uaaaaacugc uccugaaaac      300

uaugaucgac guuccggaau uagaaggacg uggggcaaug aaaauuaugu ucggucucag      360

cugaaugcca acaucaaaac ucuguuugcc uuaggaacuc cuaauccacu ggagggagaa      420

gaacuacaaa gaaaacuggc uugggaagau caaagguaca augauauaau ucagcaagac      480

uuuguugauu cuuucuacaa ucuuacucug aaauuacuua ugcaguucag uugggcaaau      540

accuauuguc cacaugccaa auuucuuaug acugcugaug augacauauu uauucacaug      600

ccaaaucuga uugaguaccu ucaaaguuua gaacaaauug guguucaaga cuuuuggauu      660

ggucguguuc aucguggugc cccucccauu agagauaaaa gcagcaaaua cuacgugucc      720

uaugaaaugu accaguggcc agcuuacccu gacuacacag ccggagcugc cuauguaauc      780

uccggugaug uagcugccaa agucuaugag gcaucacaga cacuaaauuc aagucuuuac      840

auagacgaug uguucauggg ccucugugcc aauaaaauag ggauaguacc gcaggaccau      900

guguuuuuuu cuggagaggg uaaaacuccu uaucaucccu gcaucuauga aaaaaugaug      960

acaucucaug gacacuuaga agaucuccag gaccuuugga agaaugcuac agauccuaaa     1020

guaaaaacca uuuccaaagg uuuuuuuggu caaauauacu gcagauuaau gaagauaauu     1080

cuccuuugua aaauuagcua uguggacaca uacccuugua gggcugcguu uaucuaa        1137


<210>  512
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       B3GN5__Homo_sapiens__AAH28058

<400>  512
augcgcaugc uggugagcgg ccggcgcguc aagaaguggc agcucaucau ccagcuguuc       60

gcgaccugcu uccuggccuc ccucauguuc uucugggagc ccaucgacaa ccacaucgug      120

agccacauga aguccuacag cuaccgguac cugaucaacu ccuacgacuu cgugaacgac      180

acccugagcc ucaagcacac guccgccggg ccgcgcuacc aguaccugau caaccacaag      240

gagaagugcc aggcccagga cguccugcuc cugcuguucg ugaagaccgc ccccgagaac      300

uacgaccggc gcagcggcau ccggcgcacc ugggggaacg agaacuacgu gcggucccag      360

cucaacgcca acaucaagac ccuguucgcc cugggcacgc ccaacccccu cgagggggag      420

gagcugcagc gcaagcuggc gugggaggac cagcgguaca acgacaucau ccagcaggac      480

uucgucgaca gcuucuacaa ccucacccug aagcugcuca ugcaguucuc cugggccaac      540

accuacugcc cgcacgccaa guuccugaug accgccgacg acgacaucuu cauccacaug      600

cccaaccuga ucgaguaccu ccagagccug gagcagaucg gcgugcagga cuucuggauc      660

ggccgcgugc accgcggggc gccgcccauc cgggacaagu ccagcaagua cuacgucucc      720

uacgagaugu accaguggcc cgccuacccc gacuacacgg ccggcgccgc cuacgugauc      780

agcggggacg uggcggccaa ggucuacgag gccucccaga cccugaacag cucccucuac      840

aucgacgacg uguucauggg ccugugcgcc aacaagaucg ggaucgugcc ccaggaccac      900

gucuucuuca gcggcgaggg caagaccccc uaccacccgu gcaucuacga gaagaugaug      960

accagccacg ggcaccugga ggaccuccag gaccugugga agaacgccac ggaccccaag     1020

gugaagacca ucuccaaggg cuucuucggg cagaucuacu gccggcugau gaagaucauc     1080

cuccugugca agaucagcua cguggacacc uaccccugcc gcgcggccuu caucuga        1137


<210>  513
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       B3GN5__Homo_sapiens__AAH28058

<400>  513
augcgcaugc ucgucuccgg ccgccgcguc aagaaguggc agcucaucau ccagcucuuc       60

gccaccugcu uccucgccuc ccucauguuc uucugggagc ccaucgacaa ccacaucguc      120

ucccacauga aguccuacuc cuaccgcuac cucaucaacu ccuacgacuu cgucaacgac      180

acccucuccc ucaagcacac cuccgccggc ccccgcuacc aguaccucau caaccacaag      240

gagaagugcc aggcccagga cguccuccuc cuccucuucg ucaagaccgc ccccgagaac      300

uacgaccgcc gcuccggcau ccgccgcacc uggggcaacg agaacuacgu ccgcucccag      360

cucaacgcca acaucaagac ccucuucgcc cucggcaccc ccaacccccu cgagggcgag      420

gagcuccagc gcaagcucgc cugggaggac cagcgcuaca acgacaucau ccagcaggac      480

uucgucgacu ccuucuacaa ccucacccuc aagcuccuca ugcaguucuc cugggccaac      540

accuacugcc cccacgccaa guuccucaug accgccgacg acgacaucuu cauccacaug      600

cccaaccuca ucgaguaccu ccagucccuc gagcagaucg gcguccagga cuucuggauc      660

ggccgcgucc accgcggcgc cccccccauc cgcgacaagu ccuccaagua cuacgucucc      720

uacgagaugu accaguggcc cgccuacccc gacuacaccg ccggcgccgc cuacgucauc      780

uccggcgacg ucgccgccaa ggucuacgag gccucccaga cccucaacuc cucccucuac      840

aucgacgacg ucuucauggg ccucugcgcc aacaagaucg gcaucguccc ccaggaccac      900

gucuucuucu ccggcgaggg caagaccccc uaccaccccu gcaucuacga gaagaugaug      960

accucccacg gccaccucga ggaccuccag gaccucugga agaacgccac cgaccccaag     1020

gucaagacca ucuccaaggg cuucuucggc cagaucuacu gccgccucau gaagaucauc     1080

cuccucugca agaucuccua cgucgacacc uaccccugcc gcgccgccuu caucuga        1137


<210>  514
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       B3GN5__Homo_sapiens__AAH28058

<400>  514
augagaaugc uggugagcgg caggcggguc aagaaauggc agcucaucau ucaacuuuuc       60

gcuaccugcu uucuggccuc cuugauguuc uuuugggagc ccauagacaa ccacaucguu      120

ucucauauga agucauacag uuaucgcuac uuaauuaaua gcuaugauuu cgugaacgac      180

acacuguccc uaaaacacac uucugcaggg ccucgauacc aguaucucau caaucauaag      240

gaaaaauguc aggcccagga uguacugcuu cuguuguuug ugaagacggc gccagagaac      300

uacgaccgua gaucgggaau uaggcggacc ugggguaaug aaaacuaugu ccgcucacaa      360

cucaaugcua acaucaagac acuguucgcc cugggcacuc cgaauccccu cgagggggaa      420

gaguuacaga gaaaacuggc augggaggau cagagguaca acgacauaau ccagcaagau      480

uuuguggaca gcuucuacaa ucuuaccuug aagcugcuaa ugcaguuuag uugggccaac      540

acauauugcc cucacgcuaa auuccucaug accgcagaug acgauauuuu uauccauaug      600

ccaaaucuga uugaauaccu ucagucccug gagcagaucg gaguucaaga cuucuggaua      660

ggccgggugc accgcggugc ucccccuauu cgagauaagu cuagcaaaua uuacgucucc      720

uaugaaaugu accaguggcc agccuauccc gacuacacug ccggggcggc auacgugauc      780

ucaggagacg uagccgcuaa gguuuaugag gccagucaga cauugaacag cucucucuac      840

auugaugacg uguuuauggg ccugugugca aauaagaucg gcaucguccc ucaagaucac      900

guguucuucu ccggggaggg aaaaacccca uaucauccgu gcauuuacga aaagaugaug      960

acgucacacg gucauuuaga ggaccugcag gaucucugga aaaacgcuac ugaccccaag     1020

gugaaaacca uaagcaaggg cuuuuucggg cagaucuauu guagacuuau gaaaauuauc     1080

cuguugugca agauaaguua cgucgauaca uauccuugua gggccgcguu uauuuga        1137


<210>  515
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       B3GN5__Homo_sapiens__AAH28058

<400>  515
augagaaugc uggugagcgg cagaagagug aagaaguggc agcugaucau ccagcuguuc       60

gccaccugcu uccuggccag ccugauguuc uucugggagc ccaucgacaa ccacaucgug      120

agccacauga agagcuacag cuacagauac cugaucaaca gcuacgacuu cgugaacgac      180

acccugagcc ugaagcacac cagcgccggc cccagauacc aguaccugau caaccacaag      240

gagaagugcc aggcccagga cgugcugcug cugcuguucg ugaagaccgc ccccgagaac      300

uacgacagaa gaagcggcau cagaagaacc uggggcaacg agaacuacgu gagaagccag      360

cugaacgcca acaucaagac ccuguucgcc cugggcaccc ccaacccccu ggagggcgag      420

gagcugcaga gaaagcuggc cugggaggac cagagauaca acgacaucau ccagcaggac      480

uucguggaca gcuucuacaa ccugacccug aagcugcuga ugcaguucag cugggccaac      540

accuacugcc cccacgccaa guuccugaug accgccgacg acgacaucuu cauccacaug      600

cccaaccuga ucgaguaccu gcagagccug gagcagaucg gcgugcagga cuucuggauc      660

ggcagagugc acagaggcgc cccccccauc agagacaaga gcagcaagua cuacgugagc      720

uacgagaugu accaguggcc cgccuacccc gacuacaccg ccggcgccgc cuacgugauc      780

agcggcgacg uggccgccaa gguguacgag gccagccaga cccugaacag cagccuguac      840

aucgacgacg uguucauggg ccugugcgcc aacaagaucg gcaucgugcc ccaggaccac      900

guguucuuca gcggcgaggg caagaccccc uaccaccccu gcaucuacga gaagaugaug      960

accagccacg gccaccugga ggaccugcag gaccugugga agaacgccac cgaccccaag     1020

gugaagacca ucagcaaggg cuucuucggc cagaucuacu gcagacugau gaagaucauc     1080

cugcugugca agaucagcua cguggacacc uaccccugca gagccgccuu caucuga        1137


<210>  516
<211>  1137
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       B3GN5__Homo_sapiens__AAH28058

<400>  516
augagaaugc uggugagcgg ccggcgcguc aagaaauggc agcucaucau ucaacuguuc       60

gcuaccugcu uucuugccuc ccugauguuc uuuugggagc ccaucgacaa ccacauuguu      120

ucucauauga aaagcuacuc cuauagauac cucaucaauu cuuaugauuu cgugaacgac      180

acacugagcc uuaagcacac guccgccggg ccucgguacc aguaucugau uaaucauaag      240

gaaaaauguc aggcgcagga ugugcuccug cugcucuuug ucaagaccgc uccggagaac      300

uacgaccgca gaucuggaau ccggcgcaca uggggcaaug aaaacuaugu gagaagccaa      360

cugaaugcca acaucaagac ccuuuucgcc cuggggacac ccaauccucu cgagggagag      420

gaacugcagc ggaaacuugc uugggaggau cagcgcuaca acgacauuau ccagcaagau      480

uuuguugacu ccuucuacaa ucugacccuc aagcugcuga ugcaguuuag cugggccaac      540

acauauugcc cccacgcuaa auuccucaug accgccgaug acgauauuuu uauccauaug      600

ccuaaucuga uugaauaccu ucagucucug gagcagaucg gcgugcaaga cuucuggauu      660

gggagagucc accggggagc gcccccuauc cgcgauaagu ccagcaaaua uuacgugucu      720

uaugaaaugu accaguggcc ggccuauccc gacuacacgg cuggcgccgc uuacguuauc      780

uccggcgacg uggccgcgaa ggucuaugag gccagccaga cccucaacuc uucccuguac      840

auugaugacg uguuuauggg gcuuugugcu aauaagaucg gaauugugcc ucaagaucac      900

gucuucuuca gcggcgaggg gaaaacaccc uaucauccuu gcaucuacga aaagaugaug      960

accucccacg gacaucugga ggaccuccag gaucugugga aaaacgccac agaccccaag     1020

guuaaaacca uuucuaaggg cuuuuucggg cagaucuauu guagacugau gaaaaucauu     1080

cuccugugca agaucagcua cguggauacg uauccguguc gggcugccuu uauuuga        1137


<210>  517
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  B4GN1__Homo_sapiens__Q00973

<400>  517

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
225                 230                 235                 240 


Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                245                 250                 255     


Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
            260                 265                 270         


Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
        275                 280                 285             


Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
    290                 295                 300                 


Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
305                 310                 315                 320 


Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                325                 330                 335     


Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
            340                 345                 350         


Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
        355                 360                 365             


Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
    370                 375                 380                 


Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                405                 410                 415     


Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
            420                 425                 430         


Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
        435                 440                 445             


Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
    450                 455                 460                 


Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
465                 470                 475                 480 


Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                485                 490                 495     


Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
            500                 505                 510         


Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
        515                 520                 525             


Cys Met Thr Ser Gln 
    530             


<210>  518
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  B4GN1__Homo_sapiens__AAA35516

<400>  518
auguggcugg gccgccgggc ccugugcgcu cugguccuuc ugcucgccug cgccucgcug       60

gggcuccugu acgcgagcac ccgggacgcg cccggccucc ggcuaccucu ugcgccgugg      120

gcgcccccgc aaagcccccg caggcccgag cugccagauc uugcuccuga gccccgcuac      180

gcacacaucc cggucaggau caaggagcaa guaguggggc ugcuggcuug gaacaacugc      240

aguugugagu ccaguggggg gggccucccc cuccccuucc agaaacaagu ccgagcuauu      300

gaccucacca aggccuuuga cccugcagag cugagggcug ccucugccac aagagagcag      360

gaguuccagg ccuuucuguc gaggagccag uccccagcug accagcugcu cauagccccu      420

gccaacuccc cgcuccagua cccccuacag gguguggaag uucagccccu caggagcauc      480

uuggugccag ggcugagccu ucaggcagcu ucuggucagg agguauacca ggugaaccug      540

acugccuccc uaggcaccug ggacguggca ggggaaguga cuggaguuac ucucacugga      600

gagggucagg cagaucucac ccuugucagc ccagggcugg accaacucaa caggcaacua      660

caacugguca cuuacagcag ccgaagcuac cagaccaaca cagcagacac aguccgguuc      720

uccaccgagg gacaugaggc ugcuuucacu auccgcauaa gacacccgcc caacccucgg      780

cuguacccac cugggucucu accccaggga gcccaguaca acaucagcgc ucuagucacg      840

auugccacca agaccuuccu ccguuaugau cggcuacggg cucucaucac caguauccgc      900

cgcuucuacc caacgguuac cguggucauc gcugacgaca gcgacaagcc agagcgcguu      960

aguggccccu acguggaaca cuaucucaug cccuucggca agggcugguu cgcaggccgg     1020

aaccuggccg ugucucaagu aaccaccaag uacgugcugu ggguggacga cgacuucguc     1080

uucacggcgc ggacgcggcu ggagaggcuu guggacgugc uggagcggac gccgcuggac     1140

cugguggggg gcgcggugcg cgagaucucc ggcuuugcca ccacuuaucg gcagcugcug     1200

agcguggagc ccggcgcccc aggccucggg aacugccucc ggcaaaggcg cggcuuccac     1260

cacgagcucg ucggcuuccc aggcugcgug gucaccgacg gcgugguuaa cuucuuccug     1320

gcgcggacug acaaggugcg cgaggucggu uucgaccccc gccucagccg cguggcucau     1380

cuggaauucu ucuuggaugg gcuugguucc cuucggguug gcuccugcuc cgacgucgug     1440

guggaucaug cauccaaacu gaagcugccu uggacaucaa gggaugccgg agcagagacu     1500

uacgcccggu accguuaccc aggaucacug gacgagagcc agauggccaa acaccggcug     1560

cucuucuuca aacaccggcu gcagugcaug accucccagu ga                        1602


<210>  519
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       B4GN1__Homo_sapiens__AAA35516

<400>  519
auguggcugg gccgccgggc ccucugcgcc cuggugcugc uccuggcgug cgccagccug       60

gggcuccugu acgccuccac ccgcgacgcc cccggccugc ggcucccgcu ggcccccugg      120

gcgccgcccc agagcccccg ccggcccgag cugcccgacc ucgcccccga gccgcgcuac      180

gcccacaucc ccguccggau caaggagcag gucguggggc ugcuggccug gaacaacugc      240

uccugcgaga gcuccggcgg gggccucccc cugcccuucc agaagcaggu ccgcgcgauc      300

gaccugacca aggccuucga cccggccgag cuccgggccg ccagcgcgac gcgcgagcag      360

gaguuccagg ccuuccuguc ccggagccag ucccccgccg accagcugcu caucgccccc      420

gccaacagcc cccugcagua cccgcugcag ggcguggagg ugcagccccu ccgcuccauc      480

cuggugcccg ggcugagccu ccaggcggcc uccggccagg agguguacca ggugaaccug      540

accgccagcc uggggaccug ggacgucgcc ggcgagguga ccggggugac gcucaccggc      600

gagggccagg ccgaccugac ccuggucucc cccgggcucg accagcugaa ccggcagcug      660

cagcucguga ccuacagcuc ccgcagcuac cagacgaaca ccgcggacac cgugcgguuc      720

uccaccgagg gccacgaggc cgccuucacg auccgcaucc ggcacccgcc caacccccgc      780

cuguacccgc ccgggagccu gccccagggc gcccaguaca acaucagcgc ccucgucacc      840

aucgcgacca agaccuuccu gcgguacgac cgccugcggg cccucaucac guccauccgc      900

cgcuucuacc ccaccgugac cguggucauc gccgacgaca gcgacaagcc cgagcgggug      960

uccggcccgu acguggagca cuaccugaug cccuucggga agggcugguu cgccgggcgc     1020

aaccuggcgg ucagccaggu gaccacgaag uacgugcucu gggucgacga cgacuucgug     1080

uucaccgccc ggacccgccu ggagcggcug gucgacgugc ucgagcgcac gccccuggac     1140

cuggugggcg gggccguccg ggagaucucc ggcuucgcca ccaccuaccg ccagcugcuc     1200

agcguggagc cgggcgcccc cgggcugggc aacugccugc ggcagcgccg gggguuccac     1260

cacgagcucg ugggcuuccc cgggugcguc gugaccgacg gcguggucaa cuucuuccug     1320

gcgcgcaccg acaaggugcg ggaggugggc uucgaccccc gccugucccg ggucgcccac     1380

cucgaguucu uccuggacgg gcugggcagc cuccgcgugg gguccugcag cgacgugguc     1440

guggaccacg ccuccaagcu gaagcugccg uggacgagcc gggacgccgg cgccgagacc     1500

uacgcgcgcu accgguaccc cgggucccuc gacgagagcc agauggccaa gcaccgccug     1560

cuguucuuca agcaccgccu ccagugcaug accucccagu ga                        1602


<210>  520
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       B4GN1__Homo_sapiens__AAA35516

<400>  520
auguggcucg gccgccgcgc ccucugcgcc cucguccucc uccucgccug cgccucccuc       60

ggccuccucu acgccuccac ccgcgacgcc cccggccucc gccucccccu cgcccccugg      120

gccccccccc aguccccccg ccgccccgag cuccccgacc ucgcccccga gccccgcuac      180

gcccacaucc ccguccgcau caaggagcag gucgucggcc uccucgccug gaacaacugc      240

uccugcgagu ccuccggcgg cggccucccc cuccccuucc agaagcaggu ccgcgccauc      300

gaccucacca aggccuucga ccccgccgag cuccgcgccg ccuccgccac ccgcgagcag      360

gaguuccagg ccuuccucuc ccgcucccag ucccccgccg accagcuccu caucgccccc      420

gccaacuccc cccuccagua cccccuccag ggcgucgagg uccagccccu ccgcuccauc      480

cucguccccg gccucucccu ccaggccgcc uccggccagg aggucuacca ggucaaccuc      540

accgccuccc ucggcaccug ggacgucgcc ggcgagguca ccggcgucac ccucaccggc      600

gagggccagg ccgaccucac ccucgucucc cccggccucg accagcucaa ccgccagcuc      660

cagcucguca ccuacuccuc ccgcuccuac cagaccaaca ccgccgacac cguccgcuuc      720

uccaccgagg gccacgaggc cgccuucacc auccgcaucc gccacccccc caacccccgc      780

cucuaccccc ccggcucccu cccccagggc gcccaguaca acaucuccgc ccucgucacc      840

aucgccacca agaccuuccu ccgcuacgac cgccuccgcg cccucaucac cuccauccgc      900

cgcuucuacc ccaccgucac cgucgucauc gccgacgacu ccgacaagcc cgagcgcguc      960

uccggccccu acgucgagca cuaccucaug cccuucggca agggcugguu cgccggccgc     1020

aaccucgccg ucucccaggu caccaccaag uacguccucu gggucgacga cgacuucguc     1080

uucaccgccc gcacccgccu cgagcgccuc gucgacgucc ucgagcgcac cccccucgac     1140

cucgucggcg gcgccguccg cgagaucucc ggcuucgcca ccaccuaccg ccagcuccuc     1200

uccgucgagc ccggcgcccc cggccucggc aacugccucc gccagcgccg cggcuuccac     1260

cacgagcucg ucggcuuccc cggcugcguc gucaccgacg gcgucgucaa cuucuuccuc     1320

gcccgcaccg acaagguccg cgaggucggc uucgaccccc gccucucccg cgucgcccac     1380

cucgaguucu uccucgacgg ccucggcucc cuccgcgucg gcuccugcuc cgacgucguc     1440

gucgaccacg ccuccaagcu caagcucccc uggaccuccc gcgacgccgg cgccgagacc     1500

uacgcccgcu accgcuaccc cggcucccuc gacgaguccc agauggccaa gcaccgccuc     1560

cucuucuuca agcaccgccu ccagugcaug accucccagu ga                        1602


<210>  521
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       B4GN1__Homo_sapiens__AAA35516

<400>  521
auguggcugg gcagaagggc ccucugcgcu cuugugcugu uguuagcaug ugccagccug       60

gggcuacucu acgcguccac ccgggacgcu cccggacugc gccuuccucu ggccccaugg      120

gcaccgcccc agucuccucg acguccagag uugcccgauc ucgccccuga accaagauau      180

gcucacaucc ccgucaggau uaaggagcaa guuguggguc ugcuggcaug gaacaauugc      240

ucaugugaaa guagcggcgg gggacucccu uuaccauucc agaaacaggu acgggccaua      300

gaccugacaa aggcuuuuga uccggccgag cuucgcgcgg cauccgccac uagagaacag      360

gaguuccaag cauuuuuguc uaggucgcag ucacccgccg accagcugcu aaucgcuccu      420

gcuaacagcc cacuccagua cccccugcaa ggcguggagg uccagccucu ucggaguauu      480

cuggugccag guuugucccu ccaggccgcg ucugggcagg aaguuuauca agugaaucug      540

acggccagcu uaggaaccug ggaugucgca ggcgagguga caggcguaac ucugaccggg      600

gaaggacagg cugaccucac acuuguuucc cccggucugg aucaguugaa ccgccaacua      660

cagcugguga ccuacucaag ucgaagcuau cagacuaaua cagccgacac cgucagauuc      720

ucuacggagg gccaugaggc ugccuuuacu aucaggauuc ggcacccgcc uaacccccgu      780

cucuacccac cugggucccu gccccaggga gcacaauaua auaucucagc ccuugugacc      840

auagcuacaa aaacuuuccu gcgcuacgau agauugaggg cgcucaucac cagcauucgg      900

cgauuuuacc caacagugac cgucguuauc gcagacgaua gugacaagcc cgaacgcgug      960

ucuggcccuu auguagagca uuaccugaug ccauucggua aagggugguu ugccggaaga     1020

aacuuagcug ugucccaggu cacgacuaag uaugugcugu ggguugauga cgacuucgug     1080

uuuacagcca ggacccggcu agaacgccuc gucgaugugc uggagagaac uccgcuugac     1140

uugguaggcg gcgcaguuag ggaaauuagc ggguucgcca caaccuaccg ucagcugcuc     1200

ucgguggagc ccggagcucc uggucugggc aauugccuuc ggcagcgaag aggguuucac     1260

caugagcugg ucggauuccc aggcugugug gucacggaug gugugguuaa cuucuuuuug     1320

gccaggaccg acaaggugcg cgaaguaggg uucgaucccc ggcucucuag agucgcacac     1380

cuggaguuuu ucuuagacgg ccugggaucc cuaagggugg gcucaugcag ugauguugug     1440

gucgaccacg cgagcaaacu caagcugccu uggacauccc gcgaugcugg ggccgaaacu     1500

uaugcacgau accgguaucc aggaucucuu gacgagagcc aaauggccaa acaucguuug     1560

cuguuuuuca agcacagacu ccaguguaug accucacagu ga                        1602


<210>  522
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       B4GN1__Homo_sapiens__AAA35516

<400>  522
auguggcugg gcagaagagc ccugugcgcc cuggugcugc ugcuggccug cgccagccug       60

ggccugcugu acgccagcac cagagacgcc cccggccuga gacugccccu ggcccccugg      120

gccccccccc agagccccag aagacccgag cugcccgacc uggcccccga gcccagauac      180

gcccacaucc ccgugagaau caaggagcag guggugggcc ugcuggccug gaacaacugc      240

agcugcgaga gcagcggcgg cggccugccc cugcccuucc agaagcaggu gagagccauc      300

gaccugacca aggccuucga ccccgccgag cugagagccg ccagcgccac cagagagcag      360

gaguuccagg ccuuccugag cagaagccag agccccgccg accagcugcu gaucgccccc      420

gccaacagcc cccugcagua cccccugcag ggcguggagg ugcagccccu gagaagcauc      480

cuggugcccg gccugagccu gcaggccgcc agcggccagg agguguacca ggugaaccug      540

accgccagcc ugggcaccug ggacguggcc ggcgagguga ccggcgugac ccugaccggc      600

gagggccagg ccgaccugac ccuggugagc cccggccugg accagcugaa cagacagcug      660

cagcugguga ccuacagcag cagaagcuac cagaccaaca ccgccgacac cgugagauuc      720

agcaccgagg gccacgaggc cgccuucacc aucagaauca gacacccccc caaccccaga      780

cuguaccccc ccggcagccu gccccagggc gcccaguaca acaucagcgc ccuggugacc      840

aucgccacca agaccuuccu gagauacgac agacugagag cccugaucac cagcaucaga      900

agauucuacc ccaccgugac cguggugauc gccgacgaca gcgacaagcc cgagagagug      960

agcggccccu acguggagca cuaccugaug cccuucggca agggcugguu cgccggcaga     1020

aaccuggccg ugagccaggu gaccaccaag uacgugcugu ggguggacga cgacuucgug     1080

uucaccgcca gaaccagacu ggagagacug guggacgugc uggagagaac cccccuggac     1140

cuggugggcg gcgccgugag agagaucagc ggcuucgcca ccaccuacag acagcugcug     1200

agcguggagc ccggcgcccc cggccugggc aacugccuga gacagagaag aggcuuccac     1260

cacgagcugg ugggcuuccc cggcugcgug gugaccgacg gcguggugaa cuucuuccug     1320

gccagaaccg acaaggugag agaggugggc uucgacccca gacugagcag aguggcccac     1380

cuggaguucu uccuggacgg ccugggcagc cugagagugg gcagcugcag cgacguggug     1440

guggaccacg ccagcaagcu gaagcugccc uggaccagca gagacgccgg cgccgagacc     1500

uacgccagau acagauaccc cggcagccug gacgagagcc agauggccaa gcacagacug     1560

cuguucuuca agcacagacu gcagugcaug accagccagu ga                        1602


<210>  523
<211>  1602
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       B4GN1__Homo_sapiens__AAA35516

<400>  523
auguggcugg gcagacgggc ccucugcgcu cuggugcuuc ugcucgccug ugcgagccug       60

gggcuucugu acgcuuccac ccgcgacgcc cccggacuca gacugccucu ggccccgugg      120

gcucccccuc agucuccccg gcgcccugag cuccccgauc uggccccuga accgagauau      180

gcucacaucc ccguccggau uaaggagcaa guugugggcc uucuggccug gaacaauugc      240

agcugugaau ccucuggggg aggccucccu cugcccuucc agaaacaggu gcgcgcgauc      300

gaccuuacaa aggccuuuga uccugcugag cugagagccg cuagcgccac gcgggaacag      360

gaguuccaag cguuucucuc ccgcucucag agccccgccg accagcugcu gauugcuccg      420

gccaacuccc cucuccagua cccccugcaa ggggucgagg ugcagccucu uagaagcauc      480

cugguucccg gacucucucu gcaggcugcc uccggccagg aaguguauca agucaaucuu      540

accgccagcc ugggcacaug ggauguggcu ggggagguua ccggagugac acucaccggc      600

gaagggcagg cggaccugac acuggucucu cccggacucg aucagcugaa ccggcaacuu      660

cagcugguga ccuacuccag ccgcucuuau cagacgaaua ccgccgacac agugagauuc      720

uccaccgagg gccaugaggc ugccuuuaca auucggaucc gccacccucc gaaccccaga      780

cucuacccuc ccgggagccu gccucaggga gcccaauaua auaucuccgc ucuugucacc      840

auugccacga aaacauuccu gcgguacgau agacuccgcg cgcugaucac cucuauucgg      900

agauuuuacc ccacaguuac cguggugauc gcugacgaua gcgacaagcc ggaacgcguc      960

uccggcccuu auguggagca uuaccugaug cccuucggca aagggugguu ugccggacgg     1020

aaccucgccg uuagccaggu gaccacaaag uauguccugu ggguggauga cgacuucguu     1080

uuuacggcua gaacccgccu ugaacggcug guggaugucc ucgagagaac accucuggac     1140

cuggugggcg gggccguccg cgaaauuucu ggauucgcua ccacauaccg gcagcuucuc     1200

uccguggagc ccggcgcccc ugggcuggga aauugccuga gacagcgccg gggcuuucac     1260

caugagcucg uuggcuuccc cgggugugug gucaccgaug gagugguuaa cuucuuucug     1320

gcgagaacgg acaaggugcg ggaagucggc uucgauccgc gccuuagcag aguggcccac     1380

cuggaguuuu uccucgacgg gcugggaucu cugcgggugg gcagcugcuc cgauguuguc     1440

guggaccacg cuucuaaacu uaagcucccu uggacaagca gagaugccgg ggcugaaacc     1500

uaugcccgcu accgguaucc cggcucccug gacgagagcc aaauggcgaa acauagacug     1560

cucuuuuuca agcaccgccu gcaguguaug accucucagu ga                        1602


<210>  524
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  B7H4__Homo_sapiens__Q7Z7D3

<400>  524

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  525
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  B7H4__Homo_sapiens__AAH74729

<400>  525
auggcuuccc uggggcagau ccucuucugg agcauaauua gcaucaucau uauucuggcu       60

ggagcaauug cacucaucau uggcuuuggu auuucaggga gacacuccau cacagucacu      120

acugucgccu cagcugggaa cauuggggag gauggaaucc ugagcugcac uuuugaaccu      180

gacaucaaac uuucugauau cgugauacaa uggcugaagg aagguguuuu aggcuugguc      240

caugaguuca aagaaggcaa agaugagcug ucggagcagg augaaauguu cagaggccgg      300

acagcagugu uugcugauca agugauaguu ggcaaugccu cuuugcggcu gaaaaacgug      360

caacucacag augcuggcac cuacaaaugu uauaucauca cuucuaaagg caaggggaau      420

gcuaaccuug aguauaaaac uggagccuuc agcaugccgg aagugaaugu ggacuauaau      480

gccagcucag agaccuugcg gugugaggcu ccccgauggu ucccccagcc cacagugguc      540

ugggcauccc aaguugacca gggagccaac uucucggaag ucuccaauac cagcuuugag      600

cugaacucug agaaugugac caugaagguu gugucugugc ucuacaaugu uacgaucaac      660

aacacauacu ccuguaugau ugaaaaugac auugccaaag caacagggga uaucaaagug      720

acagaaucgg agaucaaaag gcggagucac cuacagcugc uaaacucaaa ggcuucucug      780

ugugucucuu cuuucuuugc caucagcugg gcacuucugc cucucagccc uuaccugaug      840

cuaaaauaa                                                              849


<210>  526
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       B7H4__Homo_sapiens__AAH74729

<400>  526
auggccagcc ugggccagau ccucuucugg uccaucauca gcaucaucau cauccuggcc       60

ggggcgaucg cccugaucau cggcuucggg aucuccggcc gccacagcau caccgugacc      120

acggucgccu ccgccgggaa caucggcgag gacggcaucc ucagcugcac cuucgagccc      180

gacaucaagc uguccgacau cgugauccag uggcugaagg agggggugcu cggccugguc      240

cacgaguuca aggaggggaa ggacgagcug agcgagcagg acgagauguu ccggggccgc      300

accgccgugu ucgcggacca ggugaucguc gggaacgccu cccuccggcu gaagaacgug      360

cagcugaccg acgccggcac guacaagugc uacaucauca ccagcaaggg caaggggaac      420

gccaaccucg aguacaagac cggcgcguuc uccaugccgg aggugaacgu cgacuacaac      480

gccagcuccg agacccugcg cugcgaggcg ccccgguggu ucccccagcc cacgguggug      540

ugggccagcc aggucgacca gggggccaac uucuccgagg ugagcaacac cuccuucgag      600

cugaacagcg agaacgugac caugaagguc guguccgugc ucuacaacgu caccaucaac      660

aacacguaca gcugcaugau cgagaacgac aucgccaagg ccaccggcga caucaaggug      720

accgagagcg agaucaagcg ccggucccac cuccagcugc ugaacagcaa ggccucccug      780

ugcgugagcu ccuucuucgc caucagcugg gcccugcucc cgcugucccc cuaccugaug      840

cucaaguga                                                              849


<210>  527
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       B7H4__Homo_sapiens__AAH74729

<400>  527
auggccuccc ucggccagau ccucuucugg uccaucaucu ccaucaucau cauccucgcc       60

ggcgccaucg cccucaucau cggcuucggc aucuccggcc gccacuccau caccgucacc      120

accgucgccu ccgccggcaa caucggcgag gacggcaucc ucuccugcac cuucgagccc      180

gacaucaagc ucuccgacau cgucauccag uggcucaagg agggcguccu cggccucguc      240

cacgaguuca aggagggcaa ggacgagcuc uccgagcagg acgagauguu ccgcggccgc      300

accgccgucu ucgccgacca ggucaucguc ggcaacgccu cccuccgccu caagaacguc      360

cagcucaccg acgccggcac cuacaagugc uacaucauca ccuccaaggg caagggcaac      420

gccaaccucg aguacaagac cggcgccuuc uccaugcccg aggucaacgu cgacuacaac      480

gccuccuccg agacccuccg cugcgaggcc ccccgcuggu ucccccagcc caccgucguc      540

ugggccuccc aggucgacca gggcgccaac uucuccgagg ucuccaacac cuccuucgag      600

cucaacuccg agaacgucac caugaagguc gucuccgucc ucuacaacgu caccaucaac      660

aacaccuacu ccugcaugau cgagaacgac aucgccaagg ccaccggcga caucaagguc      720

accgaguccg agaucaagcg ccgcucccac cuccagcucc ucaacuccaa ggccucccuc      780

ugcgucuccu ccuucuucgc caucuccugg gcccuccucc cccucucccc cuaccucaug      840

cucaaguga                                                              849


<210>  528
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       B7H4__Homo_sapiens__AAH74729

<400>  528
auggccagcc ugggccagau ccucuucugg uccauuauau cuaucauuau cauucuugcu       60

ggggcaaucg cccugauaau cggauuuggu auuucaggca gacacaguau caccgugaca      120

acugucgcga gcgcugggaa cauuggagag gacggcaucu uguccugcac guucgaaccc      180

gauauaaagu uaucugacau uguuauccaa uggcugaaag agggugugcu agggcucgua      240

caugaauuua aggagggaaa agaugaacug ucggagcagg acgagauguu caggggccgg      300

accgccgugu uugcagauca ggucauugug ggcaaugccu cacuucgccu gaagaacguu      360

caguugacag acgcugggac uuacaaaugu uauaucauca ccagcaaggg aaaggguaau      420

gcaaaccucg aauacaaaac aggcgccuuc aguaugccug aggugaaugu cgauuauaac      480

gcuuccucug aaacccugcg augcgaggcc ccacguuggu uuccgcaacc cacuguggua      540

ugggcgagcc agguugacca gggggcaaau uucuccgagg ugucaaacac aaguuuugaa      600

cugaauagcg agaacgucac caugaaggug gugucugucc ucuacaaugu uacgauuaac      660

aauacuuauu ccuguaugau agaaaacgau aucgccaaag cuaccggaga cauuaaggug      720

acagagucag aaaucaaaag aaggagccac uuacagcugc uuaauaguaa ggccucuuug      780

ugcguaucca gcuucuuugc aauaucgugg gcucugcuac cucucucucc auaccugaug      840

cuuaaguga                                                              849


<210>  529
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       B7H4__Homo_sapiens__AAH74729

<400>  529
auggccagcc ugggccagau ccuguucugg agcaucauca gcaucaucau cauccuggcc       60

ggcgccaucg cccugaucau cggcuucggc aucagcggca gacacagcau caccgugacc      120

accguggcca gcgccggcaa caucggcgag gacggcaucc ugagcugcac cuucgagccc      180

gacaucaagc ugagcgacau cgugauccag uggcugaagg agggcgugcu gggccuggug      240

cacgaguuca aggagggcaa ggacgagcug agcgagcagg acgagauguu cagaggcaga      300

accgccgugu ucgccgacca ggugaucgug ggcaacgcca gccugagacu gaagaacgug      360

cagcugaccg acgccggcac cuacaagugc uacaucauca ccagcaaggg caagggcaac      420

gccaaccugg aguacaagac cggcgccuuc agcaugcccg aggugaacgu ggacuacaac      480

gccagcagcg agacccugag augcgaggcc cccagauggu ucccccagcc caccguggug      540

ugggccagcc agguggacca gggcgccaac uucagcgagg ugagcaacac cagcuucgag      600

cugaacagcg agaacgugac caugaaggug gugagcgugc uguacaacgu gaccaucaac      660

aacaccuaca gcugcaugau cgagaacgac aucgccaagg ccaccggcga caucaaggug      720

accgagagcg agaucaagag aagaagccac cugcagcugc ugaacagcaa ggccagccug      780

ugcgugagca gcuucuucgc caucagcugg gcccugcugc cccugagccc cuaccugaug      840

cugaaguga                                                              849


<210>  530
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       B7H4__Homo_sapiens__AAH74729

<400>  530
auggccagcc ugggccagau ccucuucugg uccauuaucu cuauuaucau uauccuggcu       60

ggggccaucg cgcuuauuau cggauuuggc auuagcggga gacacuccau caccgugaca      120

acggucgcuu cugccggaaa cauuggcgag gacgggaucc ugagcugcac cuucgaaccc      180

gauauuaagc ucuccgacau cguuauccaa uggcugaaag agggagugcu uggccuggug      240

cacgaauuua aggagggcaa agaugaacuc ucugagcagg acgagauguu ccgggggcgc      300

acagccgucu uugcugauca ggugauuguu ggaaaugcca gccugagacu gaagaacgug      360

cagcucaccg acgcuggcac auacaaaugu uauaucauua ccuccaaggg gaagggaaau      420

gccaaccugg aauacaaaac aggcgcguuc agcaugccug aggucaaugu ggauuauaac      480

gccucuuccg aaacccuucg gugcgaggcu ccgcgcuggu uuccccaacc uacgguugug      540

ugggccagcc aggucgacca gggggcuaau uucucugagg uguccaacac cagcuuugaa      600

cucaauucug agaacgugac aaugaagguc guuuccgugc uguacaaugu gaccaucaac      660

aauacauaua gcuguaugau ugaaaacgau aucgccaaag cgaccggaga caucaagguc      720

acggaguccg aaauuaaaag acggucucau cugcagcuuc ugaauagcaa ggccucccuc      780

ugcgugagcu cuuucuuugc uaucuccugg gcccugcugc cccucagccc uuaccugaug      840

cuuaaguga                                                              849


<210>  531
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BAGE-1__Homo_sapiens__Q13072

<400>  531

Met Ala Ala Arg Ala Val Phe Leu Ala Leu Ser Ala Gln Leu Leu Gln 
1               5                   10                  15      


Ala Arg Leu Met Lys Glu Glu Ser Pro Val Val Ser Trp Arg Leu Glu 
            20                  25                  30          


Pro Glu Asp Gly Thr Ala Leu Cys Phe Ile Phe 
        35                  40              


<210>  532
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BAGE-1__Homo_sapiens__AAC50123

<400>  532
auggcggcca gagcgguuuu ucuggcauug ucugcccagc ugcuccaagc caggcugaug       60

aaggaggagu ccccuguggu gagcuggagg uuggagccug aagacggcac agcucugugc      120

uucaucuucu ga                                                          132


<210>  533
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BAGE-1__Homo_sapiens__AAC50123

<400>  533
auggccgccc gcgcgguguu ccuggcccuc agcgcccagc ugcugcaggc ccggcucaug       60

aaggaggagu cccccgucgu gagcuggcgc cuggagccgg aggacggcac cgcccugugc      120

uucaucuucu ga                                                          132


<210>  534
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BAGE-1__Homo_sapiens__AAC50123

<400>  534
auggccgccc gcgccgucuu ccucgcccuc uccgcccagc uccuccaggc ccgccucaug       60

aaggaggagu cccccgucgu cuccuggcgc cucgagcccg aggacggcac cgcccucugc      120

uucaucuucu ga                                                          132


<210>  535
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BAGE-1__Homo_sapiens__AAC50123

<400>  535
auggccgcua gagcaguguu ccuggcccuc agcgcgcagc uucugcaagc uagguugaug       60

aaggaggaau cccccgucgu uucuuggcgg uuagagccug aagacggcac cgcccugugc      120

uuuaucuucu ga                                                          132


<210>  536
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BAGE-1__Homo_sapiens__AAC50123

<400>  536
auggccgcca gagccguguu ccuggcccug agcgcccagc ugcugcaggc cagacugaug       60

aaggaggaga gccccguggu gagcuggaga cuggagcccg aggacggcac cgcccugugc      120

uucaucuucu ga                                                          132


<210>  537
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BAGE-1__Homo_sapiens__AAC50123

<400>  537
auggccgcua gagccguguu ccuggcgcuc agcgcucagc ugcuucaagc ccggcugaug       60

aaggaggaau cccccgucgu uucuuggcgc cucgagccug aagacggcac cgcccugugc      120

uuuaucuucu ga                                                          132


<210>  538
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BASI__Homo_sapiens__P35613

<400>  538

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  539
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BASI__Homo_sapiens__AAN40694

<400>  539
auggcggcug cgcuguucgu gcugcuggga uucgcgcugc ugggcaccca cggagccucc       60

ggggcugccg gcuucgucca ggcgccgcug ucccagcaga gguggguggg gggcagugug      120

gagcugcacu gcgaggccgu gggcagcccg gugcccgaga uccaguggug guuugaaggg      180

caggguccca acgacaccug cucccagcuc ugggacggcg cccggcugga ccgcguccac      240

auccacgcca ccuaccacca gcacgcggcc agcaccaucu ccaucgacac gcucguggag      300

gaggacacgg gcacuuacga gugccgggcc agcaacgacc cggaucgcaa ccaccugacc      360

cgggcgccca gggucaagug gguccgcgcc caggcagucg ugcuaguccu ggaacccggc      420

acagucuuca cuaccguaga agaccuuggc uccaagauac uccucaccug cuccuugaau      480

gacagcgcca cagaggucac agggcaccgc uggcugaagg ggggcguggu gcugaaggag      540

gacgcgcugc ccggccagaa aacggaguuc aagguggacu ccgacgacca guggggagag      600

uacuccugcg ucuuccuccc cgagcccaug ggcacggcca acauccagcu ccacgggccu      660

cccagaguga aggccgugaa gucgucagaa cacaucaacg agggggagac ggccaugcug      720

gucugcaagu cagaguccgu gccaccuguc acugacuggg ccugguacaa gaucacugac      780

ucugaggaca aggcccucau gaacggcucc gagagcaggu ucuucgugag uuccucgcag      840

ggccggucag agcuacacau ugagaaccug aacauggagg ccgaccccgg ccaguaccgg      900

ugcaacggca ccagcuccaa gggcuccgac caggccauca ucacgcuccg cgugcgcagc      960

caccuggccg cccucuggcc cuuccugggc aucguggcug aggugcuggu gcuggucacc     1020

aucaucuuca ucuacgagaa gcgccggaag cccgaggacg uccuggauga ugacgacgcc     1080

ggcucugcac cccugaagag cagcgggcag caccagaaug acaaaggcaa gaacguccgc     1140

cagaggaacu cuuccuga                                                   1158


<210>  540
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BASI__Homo_sapiens__AAN40694

<400>  540
auggccgccg cccuguucgu gcugcugggc uucgcccugc ucgggaccca cggcgccagc       60

ggggccgccg gcuucgucca ggcgccccug ucccagcagc gcugggucgg gggcagcgug      120

gagcugcacu gcgaggccgu gggcuccccg gugcccgaga uccaguggug guucgagggg      180

cagggcccca acgacacgug cagccagcuc ugggacgggg cccggcugga ccgcgugcac      240

auccacgcca ccuaccacca gcacgcggcc uccaccauca gcaucgacac ccuggucgag      300

gaggacaccg gcacguacga gugccgggcc uccaacgacc ccgaccgcaa ccaccucacc      360

cgggccccgc gcgugaagug ggugcgggcc caggcggucg ugcuggugcu ggagcccggg      420

accgucuuca ccacggugga ggaccucggc agcaagaucc ugcugaccug cucccucaac      480

gacagcgcca ccgaggugac cggccaccgc uggcugaagg gcggggucgu gcugaaggag      540

gacgcccucc ccgggcagaa gacggaguuc aagguggacu ccgacgacca guggggcgag      600

uacagcugcg ucuuccugcc cgagccgaug ggcaccgcca acauccagcu gcacgggccg      660

ccccggguga aggccgugaa guccagcgag cacaucaacg agggcgagac cgcgaugcuc      720

gucugcaagu ccgagagcgu gccgcccgug accgacuggg ccugguacaa gaucacggac      780

uccgaggaca aggcccugau gaacgggagc gagucccgcu ucuucgucag cagcucccag      840

ggccggagcg agcugcacau cgagaaccuc aacauggagg ccgaccccgg gcaguaccgc      900

ugcaacggca ccuccagcaa gggcuccgac caggccauca ucacccugcg ggugcgcagc      960

caccuggcgg cccucuggcc cuuccugggg aucgucgccg aggugcuggu gcucgucacc     1020

aucaucuuca ucuacgagaa gcggcgcaag cccgaggacg ugcuggacga cgacgacgcc     1080

ggcuccgcgc cccucaagag cuccgggcag caccagaacg acaagggcaa gaacgugcgg     1140

cagcgcaaca gcuccuga                                                   1158


<210>  541
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BASI__Homo_sapiens__AAN40694

<400>  541
auggccgccg cccucuucgu ccuccucggc uucgcccucc ucggcaccca cggcgccucc       60

ggcgccgccg gcuucgucca ggccccccuc ucccagcagc gcugggucgg cggcuccguc      120

gagcuccacu gcgaggccgu cggcuccccc guccccgaga uccaguggug guucgagggc      180

cagggcccca acgacaccug cucccagcuc ugggacggcg cccgccucga ccgcguccac      240

auccacgcca ccuaccacca gcacgccgcc uccaccaucu ccaucgacac ccucgucgag      300

gaggacaccg gcaccuacga gugccgcgcc uccaacgacc ccgaccgcaa ccaccucacc      360

cgcgcccccc gcgucaagug gguccgcgcc caggccgucg uccucguccu cgagcccggc      420

accgucuuca ccaccgucga ggaccucggc uccaagaucc uccucaccug cucccucaac      480

gacuccgcca ccgaggucac cggccaccgc uggcucaagg gcggcgucgu ccucaaggag      540

gacgcccucc ccggccagaa gaccgaguuc aaggucgacu ccgacgacca guggggcgag      600

uacuccugcg ucuuccuccc cgagcccaug ggcaccgcca acauccagcu ccacggcccc      660

ccccgcguca aggccgucaa guccuccgag cacaucaacg agggcgagac cgccaugcuc      720

gucugcaagu ccgaguccgu cccccccguc accgacuggg ccugguacaa gaucaccgac      780

uccgaggaca aggcccucau gaacggcucc gagucccgcu ucuucgucuc cuccucccag      840

ggccgcuccg agcuccacau cgagaaccuc aacauggagg ccgaccccgg ccaguaccgc      900

ugcaacggca ccuccuccaa gggcuccgac caggccauca ucacccuccg cguccgcucc      960

caccucgccg cccucuggcc cuuccucggc aucgucgccg agguccucgu ccucgucacc     1020

aucaucuuca ucuacgagaa gcgccgcaag cccgaggacg uccucgacga cgacgacgcc     1080

ggcuccgccc cccucaaguc cuccggccag caccagaacg acaagggcaa gaacguccgc     1140

cagcgcaacu ccuccuga                                                   1158


<210>  542
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BASI__Homo_sapiens__AAN40694

<400>  542
auggccgccg cacuguucgu gcuccuuggc uuugcccugu uggggaccca cggagcgagc       60

ggugcugccg gcuucgucca ggcacccuua ucccaacaga gauggguugg gggaucugug      120

gagcugcauu gcgaagccgu aggcucaccu gugccagaga uccaguggug guuugaaggu      180

caggggccga acgacacaug uagucaacua ugggauggag cuaggcucga ccggguccac      240

auucaugcaa cuuaccacca gcaugccgcu agcacgauau ccaucgauac ccugguggag      300

gaagacacag gcacuuauga gugccgcgcc ucuaaugauc ccgaccgaaa ccaccuuacc      360

cgugcgccua gaguuaagug ggugagggca caggccgucg ugcugguauu ggagccaggc      420

acaguuuuca ccacugugga agaucucggg ucgaaaauuc ugcugacaug uucacucaau      480

gacagcgcua ccgaggucac gggacaccgg ugguuaaagg guggcguggu gcugaaagaa      540

gaugcccuuc ccgggcagaa gacugaguuu aaagucgaca gugaugacca auggggagag      600

uacuccugcg uuuucuugcc ugaaccaaug ggcaccgcaa acauccagcu gcaugguccc      660

ccucgcguga aggcuguaaa gucuagcgag cacauuaaug aaggggagac agccaugcua      720

guguguaaau ccgaaucagu cccaccggug acugauuggg cgugguauaa gaucaccgac      780

agugaggaca aagcccucau gaacggaagc gagucuagau uuuucguuuc cucaagccag      840

ggcaggagug aacugcauau agagaaucuu aacauggaag cagaucccgg ccaguaccgg      900

ugcaauggga caucuuccaa gggaagcgac caagcuauca uuacccugcg cgugcgaucg      960

cacuuggccg cucucuggcc uuuucugggu aucgucgccg agguguuagu acugguuacg     1020

auuaucuuca uauaugagaa aagaaggaag ccagaagaug ugcucgacga ugacgaugca     1080

ggcucugcuc cccuuaaguc cucagggcag caccagaacg acaaaggaaa gaauguccgg     1140

caacguaaca guagcuga                                                   1158


<210>  543
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BASI__Homo_sapiens__AAN40694

<400>  543
auggccgccg cccuguucgu gcugcugggc uucgcccugc ugggcaccca cggcgccagc       60

ggcgccgccg gcuucgugca ggccccccug agccagcaga gauggguggg cggcagcgug      120

gagcugcacu gcgaggccgu gggcagcccc gugcccgaga uccaguggug guucgagggc      180

cagggcccca acgacaccug cagccagcug ugggacggcg ccagacugga cagagugcac      240

auccacgcca ccuaccacca gcacgccgcc agcaccauca gcaucgacac ccugguggag      300

gaggacaccg gcaccuacga gugcagagcc agcaacgacc ccgacagaaa ccaccugacc      360

agagccccca gagugaagug ggugagagcc caggccgugg ugcuggugcu ggagcccggc      420

accguguuca ccaccgugga ggaccugggc agcaagaucc ugcugaccug cagccugaac      480

gacagcgcca ccgaggugac cggccacaga uggcugaagg gcggcguggu gcugaaggag      540

gacgcccugc ccggccagaa gaccgaguuc aagguggaca gcgacgacca guggggcgag      600

uacagcugcg uguuccugcc cgagcccaug ggcaccgcca acauccagcu gcacggcccc      660

cccagaguga aggccgugaa gagcagcgag cacaucaacg agggcgagac cgccaugcug      720

gugugcaaga gcgagagcgu gccccccgug accgacuggg ccugguacaa gaucaccgac      780

agcgaggaca aggcccugau gaacggcagc gagagcagau ucuucgugag cagcagccag      840

ggcagaagcg agcugcacau cgagaaccug aacauggagg ccgaccccgg ccaguacaga      900

ugcaacggca ccagcagcaa gggcagcgac caggccauca ucacccugag agugagaagc      960

caccuggccg cccuguggcc cuuccugggc aucguggccg aggugcuggu gcuggugacc     1020

aucaucuuca ucuacgagaa gagaagaaag cccgaggacg ugcuggacga cgacgacgcc     1080

ggcagcgccc cccugaagag cagcggccag caccagaacg acaagggcaa gaacgugaga     1140

cagagaaaca gcagcuga                                                   1158


<210>  544
<211>  1158
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BASI__Homo_sapiens__AAN40694

<400>  544
auggccgcug cccuguucgu gcuccugggc uuugcgcuuc uggggaccca cggagcuagc       60

ggcgccgccg gguucgucca ggcuccccuc ucccaacaga gauggguugg aggcucugug      120

gagcugcauu gcgaagccgu ggggagcccu gucccggaga uccaguggug guuugaagga      180

cagggcccca acgacacaug uucccaacuu ugggauggcg cucggcugga ccgcgugcac      240

auucaugcca cguaccacca gcaugcggcc ucuaccauca gcauugauac acucguugag      300

gaagacaccg ggacauauga gugcagagcu uccaaugauc cugaccggaa ccaccugacc      360

cgcgccccca gagugaagug gguccgggcu caggccgugg uucuggugcu cgagccugga      420

acagucuuca ccacggugga agaucugggc ucuaaaaucc uucugaccug uagccucaau      480

gacuccgcga cagaggugac cgggcaccgc uggcugaagg gaggcgucgu ucuuaaagaa      540

gaugcccugc ccgggcagaa gacagaguuu aaaguggaca gcgaugacca auggggagag      600

uacucuugcg uguuccuccc ugaaccgaug ggcaccgcua acauucagcu gcaugggccc      660

ccuagaguca aggccgugaa guccagcgag cacaucaaug aaggcgagac ggcuaugcug      720

guuuguaaau cugaauccgu gcccccuguc acagauuggg ccugguauaa gaucaccgac      780

agcgaggaca aagcccucau gaacggaucu gagucccggu uuuucgugag cuccucucag      840

ggccgcagcg aacugcauau ugagaaucuu aacauggaag cugaucccgg gcaguacaga      900

ugcaauggaa cauccagcaa gggcucugac caagcgauca uuacccugcg gguucgcucc      960

caccucgccg cucuguggcc guuucuuggg aucguggccg agguccuggu gcucgucacc     1020

auuaucuuca uuuaugagaa aagacggaag ccugaagaug ugcuggacga ugacgaugcc     1080

ggaagcgcuc cccugaaguc uagcggccag caccagaacg acaaaggcaa gaauguucgc     1140

caaagaaacu ccucuuga                                                   1158


<210>  545
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BCL-2__Homo_sapiens__A9QXG9

<400>  545

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Ser His Lys 
225                 230                 235                 


<210>  546
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BCL-2__Homo_sapiens__ABX60202

<400>  546
auggcgcacg cugggagaac gggguacgau aaccgggaga uagugaugaa guacauccau       60

uauaagcugu cgcagagggg cuacgagugg gaugcgggag augugggcgc cgcgcccccg      120

ggggccgccc ccgcaccggg caucuucucc ucccagcccg ggcacacgcc ccauccagcc      180

gcaucccggg acccggucgc caggaccucg ccgcugcaga ccccggcugc ccccggcgcc      240

gccgcggggc cugcgcucag cccggugcca ccuguggucc accugacccu ccgccaggcc      300

ggcgacgacu ucucccgccg cuaccgccgc gacuucgccg agauguccag ccagcugcac      360

cugacgcccu ucaccgcgcg gggacgcuuu gccacggugg uggaggagcu cuucagggac      420

ggggugaacu gggggaggau uguggccuuc uuugaguucg guggggucau guguguggag      480

agcgucaacc gggagauguc gccccuggug gacaacaucg cccuguggau gacugaguac      540

cugaaccggc accugcacac cuggauccag gauaacggag gcugggaugc cuuuguggaa      600

cuguacggcc ccagcaugcg gccucuguuu gauuucuccu ggcugucucu gaagacucug      660

cucaguuugg cccugguggg agcuugcauc acccugggug ccuaucugag ccacaaguga      720


<210>  547
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BCL-2__Homo_sapiens__ABX60202

<400>  547
auggcccacg ccggccgcac cggguacgac aaccgggaga ucgugaugaa guacauccac       60

uacaagcuga gccagcgcgg cuacgagugg gacgcggggg acgucggcgc cgcgcccccg      120

ggggccgccc ccgcccccgg caucuucucc agccagcccg gccacacccc gcaccccgcc      180

gccucccggg accccguggc ccgcacgagc ccccuccaga ccccggcggc ccccggggcc      240

gccgccggcc ccgcgcuguc ccccgugccg cccgucgugc accugacccu ccggcaggcc      300

ggggacgacu ucagccgccg guaccgccgg gacuucgccg agauguccag ccagcugcac      360

cugacccccu ucacggcccg cggccgguuc gccaccgugg ucgaggagcu guuccgcgac      420

ggggugaacu ggggccggau cguggcguuc uucgaguucg gcggggucau gugcguggag      480

uccgugaacc gcgagaugag cccccugguc gacaacaucg cccuguggau gaccgaguac      540

cucaaccggc accuccacac cuggauccag gacaacggcg ggugggacgc cuucguggag      600

cuguacggcc cguccaugcg cccccucuuc gacuucagcu ggcugucccu gaagacgcuc      660

cugagccugg cccucguggg cgccugcauc acccuggggg cguaccuguc ccacaaguga      720


<210>  548
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BCL-2__Homo_sapiens__ABX60202

<400>  548
auggcccacg ccggccgcac cggcuacgac aaccgcgaga ucgucaugaa guacauccac       60

uacaagcucu cccagcgcgg cuacgagugg gacgccggcg acgucggcgc cgcccccccc      120

ggcgccgccc ccgcccccgg caucuucucc ucccagcccg gccacacccc ccaccccgcc      180

gccucccgcg accccgucgc ccgcaccucc ccccuccaga cccccgccgc ccccggcgcc      240

gccgccggcc ccgcccucuc ccccgucccc cccgucgucc accucacccu ccgccaggcc      300

ggcgacgacu ucucccgccg cuaccgccgc gacuucgccg agauguccuc ccagcuccac      360

cucacccccu ucaccgcccg cggccgcuuc gccaccgucg ucgaggagcu cuuccgcgac      420

ggcgucaacu ggggccgcau cgucgccuuc uucgaguucg gcggcgucau gugcgucgag      480

uccgucaacc gcgagauguc cccccucguc gacaacaucg cccucuggau gaccgaguac      540

cucaaccgcc accuccacac cuggauccag gacaacggcg gcugggacgc cuucgucgag      600

cucuacggcc ccuccaugcg cccccucuuc gacuucuccu ggcucucccu caagacccuc      660

cucucccucg cccucgucgg cgccugcauc acccucggcg ccuaccucuc ccacaaguga      720


<210>  549
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BCL-2__Homo_sapiens__ABX60202

<400>  549
auggcccacg cuggcagaac cggguacgac aacagggaga ucgugaugaa guauauucau       60

uacaaacuga gccagcgggg auaugaaugg gaugccggug acgucggcgc agcgcccccu      120

ggggcugccc cagcaccggg aauauucucc ucucaacccg gccacacacc ucauccagcc      180

gcuucacgcg aucccguugc acgaacgagu ccucuccaga cuccagccgc ucccggugcc      240

gcggcagggc cugcccuuag cccagugccg cccguagugc accugaccuu gcgucaggcu      300

ggagacgauu uuuccagaag guaccggcgc gacuucgccg agaugucuuc gcaguuacau      360

cugacaccuu uuacugcaag aggcagguuc gcuaccgucg uggaagaacu auuucgggau      420

ggcguuaauu gggggcgcau cguggccuuc uuugaguucg gaggugucau gugcguggag      480

ucaguaaacc gagagaugag cccacucguu gacaauauug cgcuguggau gacagaauau      540

cuuaacagac aucugcacac cuggauccaa gauaauggcg ggugggacgc cuuuguggag      600

uuguacggac ccaguaugag gccucucuuc gauuuuuccu ggcugucucu gaagacucuc      660

uuaagccugg cacuugucgg cgcuuguauu acauugggug ccuaucuguc ccacaaauga      720


<210>  550
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BCL-2__Homo_sapiens__ABX60202

<400>  550
auggcccacg ccggcagaac cggcuacgac aacagagaga ucgugaugaa guacauccac       60

uacaagcuga gccagagagg cuacgagugg gacgccggcg acgugggcgc cgcccccccc      120

ggcgccgccc ccgcccccgg caucuucagc agccagcccg gccacacccc ccaccccgcc      180

gccagcagag accccguggc cagaaccagc ccccugcaga cccccgccgc ccccggcgcc      240

gccgccggcc ccgcccugag ccccgugccc cccguggugc accugacccu gagacaggcc      300

ggcgacgacu ucagcagaag auacagaaga gacuucgccg agaugagcag ccagcugcac      360

cugacccccu ucaccgccag aggcagauuc gccaccgugg uggaggagcu guucagagac      420

ggcgugaacu ggggcagaau cguggccuuc uucgaguucg gcggcgugau gugcguggag      480

agcgugaaca gagagaugag cccccuggug gacaacaucg cccuguggau gaccgaguac      540

cugaacagac accugcacac cuggauccag gacaacggcg gcugggacgc cuucguggag      600

cuguacggcc ccagcaugag accccuguuc gacuucagcu ggcugagccu gaagacccug      660

cugagccugg cccugguggg cgccugcauc acccugggcg ccuaccugag ccacaaguga      720


<210>  551
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BCL-2__Homo_sapiens__ABX60202

<400>  551
auggcccacg cuggcagaac cggguacgac aaccgggaga ucgugaugaa guauauucau       60

uacaaacuga gccagcgcgg auaugaaugg gaugccggcg acgucggggc ggcucccccu      120

ggagccgccc cggcucccgg caucuucucc ucucaaccug ggcacacacc ccauccugcc      180

gcuagcagag aucccguugc ccggacgucc ccucuccaga ccccggcggc ccccggagcu      240

gccgcuggcc cugcccuguc ucccgugccu cccguggucc accuuacacu gcgccaggcg      300

ggcgacgauu uuagcagacg guaccgcaga gacuucgccg agauguccuc ucagcuccau      360

cugaccccgu uuacagcucg ggggcgcuuc gccaccgugg uugaagaacu uuuuagagau      420

ggagugaauu ggggccggau ugucgcuuuc uuugaguucg ggggagugau gugcguugag      480

agcgugaacc gcgagauguc cccucugguc gacaauaucg cccucuggau gacagaauau      540

cugaacagac aucugcacac cuggauucaa gauaauggcg ggugggacgc cuuuguggag      600

cucuacggac ccagcaugcg gccucuguuc gauuuuucuu ggcuuucccu gaagacgcuc      660

cugagccuug cucugguggg cgcguguauc acccucggcg ccuaucuguc ucacaaauga      720


<210>  552
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UEZ4

<400>  552

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Gly 
            420                 425                 


<210>  553
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82700

<400>  553
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga ugguggauga                                      1290


<210>  554
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82700

<400>  554
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcggcuga                                      1290


<210>  555
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82700

<400>  555
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcggcuga                                      1290


<210>  556
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82700

<400>  556
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguggcuga                                      1290


<210>  557
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82700

<400>  557
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcggcuga                                      1290


<210>  558
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82700

<400>  558
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaggcuga                                      1290


<210>  559
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UEZ7

<400>  559

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Asp Leu Leu 
545                 550                 


<210>  560
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82703

<400>  560
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacgg cugcgcugca     1320

gaccgggcag aggagcagcg ccggcaccaa gaugggcugc ccuacauuga ugacucgccc     1380

uccucaucgc cccaccucag cagcaagggc aggggcagcc gggaugcgcu ggucucggga     1440

gcccuggagu ccacuaaagc gagugagcug gacuuggaaa agggcuugga gaugagaaaa     1500

uggguccugu cgggaauccu ggcuagcgag gagacuuacc ugagccaccu ggaggcacug     1560

cugcugccca ugaagccuuu gaaagccgcu gccaccaccu cucagccggu gcugacgagu     1620

cagcagaucg agaccaucuu cuucaaagug ccugaucucc ucuga                     1665


<210>  561
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82703

<400>  561
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacgg cugcgccgcg     1320

gaccgggccg aggagcagcg ccgccaccag gacgggcugc ccuacaucga cgacuccccc     1380

agcuccagcc cccaccuguc cagcaagggc cggggcuccc gcgacgcccu cgucagcggg     1440

gcccuggagu ccaccaaggc cagcgagcug gaccucgaga agggccugga gaugcggaag     1500

ugggugcuga gcgggauccu cgcguccgag gagaccuacc ugagccaccu ggaggcccuc     1560

cugcugccca ugaagccccu caaggccgcc gccacgaccu cccagccggu gcugaccagc     1620

cagcagaucg agaccaucuu cuucaagguc cccgaccugc ucuga                     1665


<210>  562
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82703

<400>  562
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gaccgcgccg aggagcagcg ccgccaccag gacggccucc ccuacaucga cgacuccccc     1380

uccuccuccc cccaccucuc cuccaagggc cgcggcuccc gcgacgcccu cgucuccggc     1440

gcccucgagu ccaccaaggc cuccgagcuc gaccucgaga agggccucga gaugcgcaag     1500

uggguccucu ccggcauccu cgccuccgag gagaccuacc ucucccaccu cgaggcccuc     1560

cuccucccca ugaagccccu caaggccgcc gccaccaccu cccagcccgu ccucaccucc     1620

cagcagaucg agaccaucuu cuucaagguc cccgaccucc ucuga                     1665


<210>  563
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82703

<400>  563
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacgg augcgccgcu     1320

gaccgggccg aggaacagcg uagacaucag gacggcuuac cuuauaucga ugacucuccc     1380

agcuccucac cacaccugag cucuaagggu aggggguccc gcgaugcacu uguuaguggc     1440

gccuuggaga gcaccaaggc uucugaacug gaccuagaga aaggacucga aaugcggaaa     1500

ugggugcugu ccggcauucu ugccucagag gaaacguacc ugagucauuu ggaggcacuc     1560

cuguuaccua ugaagccccu gaaggcggcu gccacuacca gccaaccagu acucacaucg     1620

cagcagaucg agacuauuuu cuucaaagug ccggaucuuc uguga                     1665


<210>  564
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82703

<400>  564
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gacagagccg aggagcagag aagacaccag gacggccugc ccuacaucga cgacagcccc     1380

agcagcagcc cccaccugag cagcaagggc agaggcagca gagacgcccu ggugagcggc     1440

gcccuggaga gcaccaaggc cagcgagcug gaccuggaga agggccugga gaugagaaag     1500

ugggugcuga gcggcauccu ggccagcgag gagaccuacc ugagccaccu ggaggcccug     1560

cugcugccca ugaagccccu gaaggccgcc gccaccacca gccagcccgu gcugaccagc     1620

cagcagaucg agaccaucuu cuucaaggug cccgaccugc uguga                     1665


<210>  565
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82703

<400>  565
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacgg augcgccgcc     1320

gaccgggcug aggaacagag acgccaucag gacggccugc ccuauaucga ugacuccccu     1380

agcucuagcc cccaccuuuc cucuaagggg agaggaagcc gggaugcccu gguguccggc     1440

gcucucgaga gcaccaaagc cucugaacug gaccuggaga aggggcucga aaugcgcaaa     1500

uggguccugu ccggcauucu ugcgagcgag gaaaccuacc ugucccaucu cgaggcccug     1560

cuucugccua ugaagccccu caaggcugcc gcuacaaccu cucaaccggu gcugacgagc     1620

cagcagaucg agacaauuuu cuucaaaguu ccugaucugc ucuga                     1665


<210>  566
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UEZ8

<400>  566

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Ile 
            500                 505                 510         


Thr Leu 
        


<210>  567
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82704

<400>  567
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacgg cugcgcugca     1320

gaccgggcag aggagcagcg ccggcaccaa gaugggcugc ccuacauuga ugacucgccc     1380

uccucaucgc cccaccucag cagcaagggc aggggcagcc gggaugcgcu ggucucggga     1440

gcccuggagu ccacuaaagc gagugagcug gacuuggaaa agggcuugga gaugagaaaa     1500

uggguccugu cgggaauccu ggcuagcgag gagauaacac ucuaa                     1545


<210>  568
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82704

<400>  568
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacgg cugcgccgcg     1320

gaccgggccg aggagcagcg ccgccaccag gacgggcugc ccuacaucga cgacuccccc     1380

agcuccagcc cccaccuguc cagcaagggc cggggcuccc gcgacgcccu cgucagcggg     1440

gcccuggagu ccaccaaggc cagcgagcug gaccucgaga agggccugga gaugcggaag     1500

ugggugcuga gcgggauccu cgcguccgag gagaucaccc uguga                     1545


<210>  569
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82704

<400>  569
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gaccgcgccg aggagcagcg ccgccaccag gacggccucc ccuacaucga cgacuccccc     1380

uccuccuccc cccaccucuc cuccaagggc cgcggcuccc gcgacgcccu cgucuccggc     1440

gcccucgagu ccaccaaggc cuccgagcuc gaccucgaga agggccucga gaugcgcaag     1500

uggguccucu ccggcauccu cgccuccgag gagaucaccc ucuga                     1545


<210>  570
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82704

<400>  570
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacgg augcgccgcu     1320

gaccgggccg aggaacagcg uagacaucag gacggcuuac cuuauaucga ugacucuccc     1380

agcuccucac cacaccugag cucuaagggu aggggguccc gcgaugcacu uguuaguggc     1440

gccuuggaga gcaccaaggc uucugaacug gaccuagaga aaggacucga aaugcggaaa     1500

ugggugcugu ccggcauucu ugccucagag gaaaucacgc uguga                     1545


<210>  571
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82704

<400>  571
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gacagagccg aggagcagag aagacaccag gacggccugc ccuacaucga cgacagcccc     1380

agcagcagcc cccaccugag cagcaagggc agaggcagca gagacgcccu ggugagcggc     1440

gcccuggaga gcaccaaggc cagcgagcug gaccuggaga agggccugga gaugagaaag     1500

ugggugcuga gcggcauccu ggccagcgag gagaucaccc uguga                     1545


<210>  572
<211>  1545
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82704

<400>  572
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacgg augcgccgcc     1320

gaccgggcug aggaacagag acgccaucag gacggccugc ccuauaucga ugacuccccu     1380

agcucuagcc cccaccuuuc cucuaagggg agaggaagcc gggaugcccu gguguccggc     1440

gcucucgaga gcaccaaagc cucugaacug gaccuggaga aggggcucga aaugcgcaaa     1500

uggguccugu ccggcauucu ugcgagcgag gaaaucaccc uguga                     1545


<210>  573
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UEZ9

<400>  573

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Leu Glu Leu 
            420                 425                 430         


Gln Gly Lys Pro Ser Arg Trp Thr Gln 
        435                 440     


<210>  574
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82705

<400>  574
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguug gaacuccaag gaaaaccuuc ucgcuggacc     1320

caguga                                                                1326


<210>  575
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82705

<400>  575
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagccug gagcugcagg gcaagcccuc ccgguggacc     1320

caguga                                                                1326


<210>  576
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82705

<400>  576
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcucccuc gagcuccagg gcaagcccuc ccgcuggacc     1320

caguga                                                                1326


<210>  577
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82705

<400>  577
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuua gaacugcagg gcaagccauc ucgguggaca     1320

caguga                                                                1326


<210>  578
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82705

<400>  578
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagccug gagcugcagg gcaagcccag cagauggacc     1320

caguga                                                                1326


<210>  579
<211>  1326
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82705

<400>  579
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucucug gaacuucagg gcaagcccuc ccgguggacc     1320

caguga                                                                1326


<210>  580
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF00

<400>  580

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Asp Pro Val Lys Met Thr Pro Thr Phe Ser Leu 
            500                 505                 510         


His Cys Met Ile Leu Trp Pro Val Glu Ile Thr Leu 
        515                 520                 


<210>  581
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82706

<400>  581
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacgg cugcgcugca     1320

gaccgggcag aggagcagcg ccggcaccaa gaugggcugc ccuacauuga ugacucgccc     1380

uccucaucgc cccaccucag cagcaagggc aggggcagcc gggaugcgcu ggucucggga     1440

gcccuggagu ccacuaaagc gagugagcug gacuuggaaa agggcuugga gaugagaaaa     1500

ugggacccag ugaaaaugac cccaaccuuu ucguugcacu guaugauuuu guggccagug     1560

gagauaacac ucuaa                                                      1575


<210>  582
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82706

<400>  582
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacgg cugcgccgcg     1320

gaccgggccg aggagcagcg ccgccaccag gacgggcugc ccuacaucga cgacuccccc     1380

agcuccagcc cccaccuguc cagcaagggc cggggcuccc gcgacgcccu cgucagcggg     1440

gcccuggagu ccaccaaggc cagcgagcug gaccucgaga agggccugga gaugcggaag     1500

ugggaccccg ugaagaugac ccccacguuc agccugcacu gcaugauccu cuggccggug     1560

gagaucaccc uguga                                                      1575


<210>  583
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82706

<400>  583
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gaccgcgccg aggagcagcg ccgccaccag gacggccucc ccuacaucga cgacuccccc     1380

uccuccuccc cccaccucuc cuccaagggc cgcggcuccc gcgacgcccu cgucuccggc     1440

gcccucgagu ccaccaaggc cuccgagcuc gaccucgaga agggccucga gaugcgcaag     1500

ugggaccccg ucaagaugac ccccaccuuc ucccuccacu gcaugauccu cuggcccguc     1560

gagaucaccc ucuga                                                      1575


<210>  584
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82706

<400>  584
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacgg augcgccgcu     1320

gaccgggccg aggaacagcg uagacaucag gacggcuuac cuuauaucga ugacucuccc     1380

agcuccucac cacaccugag cucuaagggu aggggguccc gcgaugcacu uguuaguggc     1440

gccuuggaga gcaccaaggc uucugaacug gaccuagaga aaggacucga aaugcggaaa     1500

ugggauccug ugaagaugac gcccacuuuc ucccugcauu guaugauucu uuggccagua     1560

gagaucaccc uguga                                                      1575


<210>  585
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82706

<400>  585
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gacagagccg aggagcagag aagacaccag gacggccugc ccuacaucga cgacagcccc     1380

agcagcagcc cccaccugag cagcaagggc agaggcagca gagacgcccu ggugagcggc     1440

gcccuggaga gcaccaaggc cagcgagcug gaccuggaga agggccugga gaugagaaag     1500

ugggaccccg ugaagaugac ccccaccuuc agccugcacu gcaugauccu guggcccgug     1560

gagaucaccc uguga                                                      1575


<210>  586
<211>  1575
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82706

<400>  586
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacgg augcgccgcc     1320

gaccgggcug aggaacagag acgccaucag gacggccugc ccuauaucga ugacuccccu     1380

agcucuagcc cccaccuuuc cucuaagggg agaggaagcc gggaugcccu gguguccggc     1440

gcucucgaga gcaccaaagc cucugaacug gaccuggaga aggggcucga aaugcgcaaa     1500

ugggauccug ucaagaugac ccccacauuc ucccugcauu guaugauucu uuggccggug     1560

gagaucaccc uguga                                                      1575


<210>  587
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF01

<400>  587

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Glu His Pro Gly Ala Ala Glu Glu 
            420                 425                 430         


Val Phe Gln Lys Leu Leu Pro Asp Ile Arg Gly Ala Ala Asp Ala Asp 
        435                 440                 445             


Gln Leu Val Cys Glu Thr Pro Asp Cys Pro Gln His Ser Ala Asp His 
    450                 455                 460                 


Gln 
465 


<210>  588
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82707

<400>  588
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagaacaucc gggagcagca gaagaagugu uucagaagcu ucucccugac     1320

auccguggag cugcagaugc ugaccaacuc gugugugaaa cuccagacug uccacagcau     1380

uccgcugacc aucaauaa                                                   1398


<210>  589
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82707

<400>  589
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggagcaccc cggcgccgcc gaggaggucu uccagaagcu gcugcccgac     1320

auccggggcg cggccgacgc cgaccagcuc gugugcgaga cccccgacug cccgcagcac     1380

agcgccgacc accaguga                                                   1398


<210>  590
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82707

<400>  590
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgagcaccc cggcgccgcc gaggaggucu uccagaagcu ccuccccgac     1320

auccgcggcg ccgccgacgc cgaccagcuc gucugcgaga cccccgacug cccccagcac     1380

uccgccgacc accaguga                                                   1398


<210>  591
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82707

<400>  591
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagaacaucc aggugcagcc gaggagguuu uucagaaguu acugcccgac     1320

auccggggcg cugccgaugc agaccagcuu gugugcgaaa caccugacug uccccaacac     1380

agugccgauc aucaguga                                                   1398


<210>  592
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82707

<400>  592
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgagcaccc cggcgccgcc gaggaggugu uccagaagcu gcugcccgac     1320

aucagaggcg ccgccgacgc cgaccagcug gugugcgaga cccccgacug cccccagcac     1380

agcgccgacc accaguga                                                   1398


<210>  593
<211>  1398
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82707

<400>  593
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgaacaucc cggagcugcc gaggaggugu uucagaagcu gcuuccugac     1320

auccggggcg ccgcugaugc cgaccagcug gucugcgaaa cccccgacug uccucaacac     1380

ucugcugauc aucaguga                                                   1398


<210>  594
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF03

<400>  594

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Cys Cys Leu Cys Leu Pro Ala Trp Pro Ser Gly Cys 
        435                 440                 445             


Thr Ala Ala Thr Ala Arg Val Thr Arg Ser 
    450                 455             


<210>  595
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82709

<400>  595
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacug cugcuuaugu     1320

cucccagcau ggccuucagg gugcacagcc gcaacggcaa gaguuacacg uuccuga        1377


<210>  596
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82709

<400>  596
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacug cugccugugc     1320

cugcccgccu ggcccuccgg cugcaccgcg gccaccgccc gggucacgcg cagcuga        1377


<210>  597
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82709

<400>  597
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacug cugccucugc     1320

cuccccgccu ggcccuccgg cugcaccgcc gccaccgccc gcgucacccg cuccuga        1377


<210>  598
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82709

<400>  598
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacug cuguuuaugc     1320

cugccugccu ggcccucugg auguaccgcu gccacggcac ggguuacucg uagcuga        1377


<210>  599
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82709

<400>  599
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacug cugccugugc     1320

cugcccgccu ggcccagcgg cugcaccgcc gccaccgcca gagugaccag aagcuga        1377


<210>  600
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82709

<400>  600
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacug cugucugugc     1320

cuucccgccu ggccuuccgg auguaccgcc gcuaccgccc gggugacaag aagcuga        1377


<210>  601
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF04

<400>  601

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Gly Arg Pro Pro His Leu Thr Glu 
        435                 440                 445             


Leu Pro Val Gln His Gln 
    450                 


<210>  602
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82710

<400>  602
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacgg cugcgcugca     1320

ggacgcccuc cgcaucucac agaacuuccu guccagcauc aauga                     1365


<210>  603
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82710

<400>  603
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguuccccga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacgg cugcgccgcg     1320

gggcggccgc cccaccugac cgagcugccc guccagcacc aguga                     1365


<210>  604
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82710

<400>  604
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

ggccgccccc cccaccucac cgagcucccc guccagcacc aguga                     1365


<210>  605
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82710

<400>  605
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacgg augcgccgcu     1320

ggccggccuc cccauuuaac cgaacugcca guucagcacc aguga                     1365


<210>  606
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82710

<400>  606
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

ggcagacccc cccaccugac cgagcugccc gugcagcacc aguga                     1365


<210>  607
<211>  1365
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82710

<400>  607
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacgg augcgccgcc     1320

ggccggcccc cucaucugac cgaacuuccc gugcagcacc aguga                     1365


<210>  608
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF05

<400>  608

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Val Leu Lys Thr Glu Val 
            420                 425                 430         


Pro His Gln Gly Val Arg Arg Ala Arg Leu Ser Leu Glu Ala Leu Gly 
        435                 440                 445             


Glu Asp Pro Ser Phe Leu Phe Pro Ala Ser Asp Gly Pro Arg His Ser 
    450                 455                 460                 


Ser Thr Trp 
465         


<210>  609
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82711

<400>  609
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcagu ucugaagacu gaagucccac aucaaggugu ccgcagggcc     1320

aggcugucuc uggaggcucu aggggaggau ccuuccuuuc uguucccagc aucugauggc     1380

ccacggcauu ccucgaccug guga                                            1404


<210>  610
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82711

<400>  610
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccgu ccugaagacc gaggugcccc accagggcgu gcggcgcgcc     1320

cgccugagcc ucgaggcgcu gggcgaggac cccuccuucc uguuccccgc cagcgacggg     1380

ccgcggcacu ccagcaccug guga                                            1404


<210>  611
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82711

<400>  611
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccgu ccucaagacc gagguccccc accagggcgu ccgccgcgcc     1320

cgccucuccc ucgaggcccu cggcgaggac cccuccuucc ucuuccccgc cuccgacggc     1380

ccccgccacu ccuccaccug guga                                            1404


<210>  612
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82711

<400>  612
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcagu uuuaaagaca gaagugccac aucagggugu acggcgugcc     1320

agacugaguc uugaggcuuu gggcgaggau cccucuuuuc uguucccugc cagcgacggg     1380

cccaggcacu ccucaaccug guga                                            1404


<210>  613
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82711

<400>  613
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccgu gcugaagacc gaggugcccc accagggcgu gagaagagcc     1320

agacugagcc uggaggcccu gggcgaggac cccagcuucc uguuccccgc cagcgacggc     1380

cccagacaca gcagcaccug guga                                            1404


<210>  614
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82711

<400>  614
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcugu gcugaagacc gaaguccccc aucagggagu gcggagagcc     1320

cgccuuucuc uggaggcccu cggcgaggau ccuuccuuuc uguuccccgc uagcgacggg     1380

ccuagacacu cuuccacaug guga                                            1404


<210>  615
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF06

<400>  615

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Pro Val Lys Met Thr 
                485                 490                 495     


Pro Thr Phe Ser Leu His Cys Met Ile Leu Trp Pro Val Glu Ile Thr 
            500                 505                 510         


Leu 
    


<210>  616
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82712

<400>  616
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca ucgugggcgu ccgcaagacc gggcagaucu ggcccaacga uggcgagggc     1260

gccuuccaug gagacgcaga uggcucguuc ggaacaccac cuggauacgg cugcgcugca     1320

gaccgggcag aggagcagcg ccggcaccaa gaugggcugc ccuacauuga ugacucgccc     1380

uccucaucgc cccaccucag cagcaagggc aggggcagcc gggaugcgcu ggucucggga     1440

gcccuggagu ccacuaaagc gagugagcug gacccaguga aaaugacccc aaccuuuucg     1500

uugcacugua ugauuuugug gccaguggag auaacacucu aa                        1542


<210>  617
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82712

<400>  617
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccacgagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca ucgugggggu gcgcaagacc ggccagaucu ggccgaacga cggggagggc     1260

gccuuccacg gggacgccga cggcagcuuc ggcaccccgc ccggguacgg cugcgccgcg     1320

gaccgggccg aggagcagcg ccgccaccag gacgggcugc ccuacaucga cgacuccccc     1380

agcuccagcc cccaccuguc cagcaagggc cggggcuccc gcgacgcccu cgucagcggg     1440

gcccuggagu ccaccaaggc cagcgagcug gaccccguga agaugacccc cacguucagc     1500

cuccacugca ugauccugug gccgguggag aucacccugu ga                        1542


<210>  618
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82712

<400>  618
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccacca ucgucggcgu ccgcaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcuccuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gaccgcgccg aggagcagcg ccgccaccag gacggccucc ccuacaucga cgacuccccc     1380

uccuccuccc cccaccucuc cuccaagggc cgcggcuccc gcgacgcccu cgucuccggc     1440

gcccucgagu ccaccaaggc cuccgagcuc gaccccguca agaugacccc caccuucucc     1500

cuccacugca ugauccucug gcccgucgag aucacccucu ga                        1542


<210>  619
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82712

<400>  619
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca ucgugggcgu ccgaaaaacu ggacagauau ggccuaacga uggcgagggg     1260

gcguuccacg gagacgcaga ugguaguuuu ggcacaccac ccggguacgg augcgccgcu     1320

gaccgggccg aggaacagcg uagacaucag gacggcuuac cuuauaucga ugacucuccc     1380

agcuccucac cacaccugag cucuaagggu aggggguccc gcgaugcacu uguuaguggc     1440

gccuuggaga gcaccaaggc uucugaacug gacccuguga aaaugacgcc cacuuucucc     1500

cuacauugua ugauucucug gccaguagag aucacccugu ga                        1542


<210>  620
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82712

<400>  620
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca ucgugggcgu gagaaagacc ggccagaucu ggcccaacga cggcgagggc     1260

gccuuccacg gcgacgccga cggcagcuuc ggcacccccc ccggcuacgg cugcgccgcc     1320

gacagagccg aggagcagag aagacaccag gacggccugc ccuacaucga cgacagcccc     1380

agcagcagcc cccaccugag cagcaagggc agaggcagca gagacgcccu ggugagcggc     1440

gcccuggaga gcaccaaggc cagcgagcug gaccccguga agaugacccc caccuucagc     1500

cugcacugca ugauccugug gcccguggag aucacccugu ga                        1542


<210>  621
<211>  1542
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82712

<400>  621
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccacca ucguuggggu gcgcaaaacg ggacagauuu ggccgaacga uggcgagggg     1260

gcguuccacg gcgacgcuga uggaucuuuu ggcacacccc cuggguacgg augcgccgcc     1320

gaccgggcug aggaacagag acgccaucag gacggccugc ccuauaucga ugacuccccu     1380

agcucuagcc cccaccuuuc cucuaagggg agaggaagcc gggaugcccu gguguccggc     1440

gcucucgaga gcaccaaagc cucugaacug gacccuguca agaugacccc cacauucucc     1500

cugcauugua ugauucucug gccgguggag aucacccugu ga                        1542


<210>  622
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__A9UF08

<400>  622

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ser Gly Gln 
                405     


<210>  623
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  bcr/abl__Homo_sapiens__ABX82714

<400>  623
augguggacc cggugggcuu cgcggaggcg uggaaggcgc aguucccgga cucagagccc       60

ccgcgcaugg agcugcgcuc agugggcgac aucgagcagg agcuggagcg cugcaaggcc      120

uccauucggc gccuggagca ggaggugaac caggagcgcu uccgcaugau cuaccugcag      180

acguugcugg ccaaggaaaa gaagagcuau gaccggcagc gauggggcuu ccggcgcgcg      240

gcgcaggccc ccgacggcgc cuccgagccc cgagcguccg cgucgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

gguucuccgg guaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgucgggg      420

gaacgggacg accggggacc ccccgccagc guggcggcgc ucagguccaa cuucgagcgg      480

auccgcaagg gccauggcca gcccggggcg gacgccgaga agcccuucua cgugaacguc      540

gaguuucacc acgagcgcgg ccuggugaag gucaacgaca aagagguguc ggaccgcauc      600

agcucccugg gcagccaggc caugcagaug gagcgcaaaa agucccagca cggcgcgggc      660

ucgagcgugg gggaugcauc caggcccccu uaccggggac gcuccucgga gagcagcugc      720

ggcgucgacg gcgacuacga ggacgccgag uugaaccccc gcuuccugaa ggacaaccug      780

aucgacgcca auggcgguag caggcccccu uggccgcccc uggaguacca gcccuaccag      840

agcaucuacg ucgggggcau gauggaaggg gagggcaagg gcccgcuccu gcgcagccag      900

agcaccucug agcaggagaa gcgccuuacc uggccccgca gguccuacuc cccccggagu      960

uuugaggauu gcggaggcgg cuauaccccg gacugcagcu ccaaugagaa ccucaccucc     1020

agcgaggagg acuucuccuc uggccagucc agccgcgugu ccccaagccc caccaccuac     1080

cgcauguucc gggacaaaag ccgcucuccc ucgcagaacu cgcaacaguc cuucgacagc     1140

agcagucccc ccacgccgca gugccauaag cggcaccggc acugcccggu ugucgugucc     1200

gaggccacca gcggccagua g                                               1221


<210>  624
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       bcr/abl__Homo_sapiens__ABX82714

<400>  624
augguggacc ccgucggcuu cgccgaggcc uggaaggcgc aguucccgga cagcgagccg       60

ccccgcaugg agcugcgguc cgugggggac aucgagcagg agcucgagcg cugcaaggcc      120

agcauccggc gccuggagca ggaggugaac caggagcggu uccgcaugau cuaccugcag      180

acccuccugg ccaaggagaa gaaguccuac gaccggcagc gcuggggcuu ccggcgcgcc      240

gcccaggcgc ccgacggggc cagcgagccc cgggccuccg ccagccgccc ccagcccgcg      300

cccgccgacg gcgccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggggag      360

ggcucccccg gcaaggcgcg ccccgggacc gcccggcgcc ccggcgccgc cgccagcggg      420

gagcgggacg accgcggccc gcccgcgucc gucgccgccc ugcggagcaa cuucgagcgc      480

auccggaagg ggcacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagcgcgg gcucgucaag gugaacgaca aggagguguc cgaccgcauc      600

agcucccugg gcagccaggc gaugcagaug gagcggaaga agucccagca cggggccggc      660

agcuccgucg gcgacgccag ccgcccgccc uaccgggggc gcuccagcga gagcuccugc      720

ggcguggacg gggacuacga ggacgccgag cugaaccccc gguuccucaa ggacaaccug      780

aucgacgcca acggcgggag ccggcccccg uggccgcccc uggaguacca gcccuaccag      840

uccaucuacg ugggcggcau gauggagggg gagggcaagg ggccccuccu gcgcagccag      900

uccaccagcg agcaggagaa gcgccugacc uggccccggc gcuccuacag cccccggucc      960

uucgaggacu gcggcggggg cuacaccccg gacugcagcu ccaacgagaa ccucaccagc     1020

uccgaggagg acuucagcuc cggccagagc ucccgcguca gccccucccc cacgaccuac     1080

cggauguucc gcgacaagag ccggagcccc ucccagaaca gccagcaguc cuucgacagc     1140

uccagcccgc ccacgcccca gugccacaag cgccaccggc acugccccgu gguggucucc     1200

gaggcgacca gcgggcagug a                                               1221


<210>  625
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       bcr/abl__Homo_sapiens__ABX82714

<400>  625
auggucgacc ccgucggcuu cgccgaggcc uggaaggccc aguuccccga cuccgagccc       60

ccccgcaugg agcuccgcuc cgucggcgac aucgagcagg agcucgagcg cugcaaggcc      120

uccauccgcc gccucgagca ggaggucaac caggagcgcu uccgcaugau cuaccuccag      180

acccuccucg ccaaggagaa gaaguccuac gaccgccagc gcuggggcuu ccgccgcgcc      240

gcccaggccc ccgacggcgc cuccgagccc cgcgccuccg ccucccgccc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggcccgccc cgacggcgag      360

ggcucccccg gcaaggcccg ccccggcacc gcccgccgcc ccggcgccgc cgccuccggc      420

gagcgcgacg accgcggccc ccccgccucc gucgccgccc uccgcuccaa cuucgagcgc      480

auccgcaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgucaacguc      540

gaguuccacc acgagcgcgg ccucgucaag gucaacgaca aggaggucuc cgaccgcauc      600

uccucccucg gcucccaggc caugcagaug gagcgcaaga agucccagca cggcgccggc      660

uccuccgucg gcgacgccuc ccgccccccc uaccgcggcc gcuccuccga guccuccugc      720

ggcgucgacg gcgacuacga ggacgccgag cucaaccccc gcuuccucaa ggacaaccuc      780

aucgacgcca acggcggcuc ccgccccccc uggccccccc ucgaguacca gcccuaccag      840

uccaucuacg ucggcggcau gauggagggc gagggcaagg gcccccuccu ccgcucccag      900

uccaccuccg agcaggagaa gcgccucacc uggccccgcc gcuccuacuc cccccgcucc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcuccu ccaacgagaa ccucaccucc     1020

uccgaggagg acuucuccuc cggccagucc ucccgcgucu cccccucccc caccaccuac     1080

cgcauguucc gcgacaaguc ccgcuccccc ucccagaacu cccagcaguc cuucgacucc     1140

uccucccccc ccacccccca gugccacaag cgccaccgcc acugccccgu cgucgucucc     1200

gaggccaccu ccggccagug a                                               1221


<210>  626
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       bcr/abl__Homo_sapiens__ABX82714

<400>  626
augguggacc ccgucggcuu cgccgaggcu uggaaggcac aguuuccuga uagcgaacca       60

ccgagaaugg agcugagguc cguuggggac aucgaacaag agcucgaacg gugcaaagcc      120

ucuauucgcc gacuugagca ggaggugaac caggaacguu ucagaaugau auaccugcag      180

accuuguuag cgaaggagaa aaagucauau gauaggcaac gguggggauu ucgcagagcu      240

gcccaggcac ccgacggugc cagugaaccu agggcuagcg caucccggcc acagcccgcc      300

ccugcugaug gcgccgaccc acccccugcg gaggagccag aagcacgccc ggauggggag      360

ggaucucccg gcaaagcccg accugguaca gcuagaaggc caggggccgc agcuucggga      420

gaacgggacg aucgugggcc cccugccuca guagcggccc ugcgcagcaa uuucgagaga      480

aucaggaagg gccacggcca gccaggagca gacgcugaaa agcccuuuua cgugaacguc      540

gaguuccauc acgagcgggg ucuagugaaa guuaaugaua aggaagugag ugaccgaauu      600

uccucucucg gcagccaagc caugcagaug gagcgcaaaa agucccagca uggggcugga      660

ucaagugucg gcgaugccag cagaccgccu uauagggguc ggucuuccga aucaagcugu      720

gggguggacg gagacuacga ggaugcagaa cugaaccccc gcuuucuuaa agacaaucug      780

aucgaugcca acggcggcag uagaccaccu uggcccccau uggaguauca gcccuaccaa      840

ucuauuuaug uagggggaau gauggagggu gaaggcaagg ggccucuccu gaggucccag      900

agcacuucgg agcaggaaaa gcgucugacg uggccacggc gaucuuacuc cccgagauca      960

uucgaggacu gcggaggcgg uuacaccccc gauuguagua gcaaugaaaa ccucacaucc     1020

ucugaggagg acuuuagcuc agggcaaagu uccaggguua gcccuucucc aacuaccuau     1080

cgcauguucc gggauaaauc aagaaguccc agccaaaauu cccagcaguc uuuugacucg     1140

agcuccccuc caacacccca gugccacaag aggcaucgcc acuguccggu ggucguguca     1200

gaagcuacca guggccagug a                                               1221


<210>  627
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       bcr/abl__Homo_sapiens__ABX82714

<400>  627
augguggacc ccgugggcuu cgccgaggcc uggaaggccc aguuccccga cagcgagccc       60

cccagaaugg agcugagaag cgugggcgac aucgagcagg agcuggagag augcaaggcc      120

agcaucagaa gacuggagca ggaggugaac caggagagau ucagaaugau cuaccugcag      180

acccugcugg ccaaggagaa gaagagcuac gacagacaga gauggggcuu cagaagagcc      240

gcccaggccc ccgacggcgc cagcgagccc agagccagcg ccagcagacc ccagcccgcc      300

cccgccgacg gcgccgaccc cccccccgcc gaggagcccg aggccagacc cgacggcgag      360

ggcagccccg gcaaggccag acccggcacc gccagaagac ccggcgccgc cgccagcggc      420

gagagagacg acagaggccc ccccgccagc guggccgccc ugagaagcaa cuucgagaga      480

aucagaaagg gccacggcca gcccggcgcc gacgccgaga agcccuucua cgugaacgug      540

gaguuccacc acgagagagg ccuggugaag gugaacgaca aggaggugag cgacagaauc      600

agcagccugg gcagccaggc caugcagaug gagagaaaga agagccagca cggcgccggc      660

agcagcgugg gcgacgccag cagacccccc uacagaggca gaagcagcga gagcagcugc      720

ggcguggacg gcgacuacga ggacgccgag cugaacccca gauuccugaa ggacaaccug      780

aucgacgcca acggcggcag cagacccccc uggccccccc uggaguacca gcccuaccag      840

agcaucuacg ugggcggcau gauggagggc gagggcaagg gcccccugcu gagaagccag      900

agcaccagcg agcaggagaa gagacugacc uggcccagaa gaagcuacag ccccagaagc      960

uucgaggacu gcggcggcgg cuacaccccc gacugcagca gcaacgagaa ccugaccagc     1020

agcgaggagg acuucagcag cggccagagc agcagaguga gccccagccc caccaccuac     1080

agaauguuca gagacaagag cagaagcccc agccagaaca gccagcagag cuucgacagc     1140

agcagccccc ccacccccca gugccacaag agacacagac acugccccgu gguggugagc     1200

gaggccacca gcggccagug a                                               1221


<210>  628
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       bcr/abl__Homo_sapiens__ABX82714

<400>  628
augguggacc ccgucggcuu cgccgaggcu uggaaggccc aguuuccuga uagcgaaccg       60

cccagaaugg agcugcgguc cguuggggac aucgaacaag agcucgaacg cugcaaagcg      120

ucuauuagac ggcuggagca ggaggugaac caggaacgcu ucagaaugau cuaccuucag      180

acccugcucg cuaaggagaa aaagagcuau gaucggcaac gcuggggauu uagacgggcc      240

gcccaggcuc cugacggcgc cuccgaaccc cgcgcuucug ccagcagacc ucagcccgcg      300

ccugccgaug gggcugaccc gcccccugcc gaggagcccg aagcucggcc ugauggagag      360

ggcucccccg ggaaagcccg cccgggaaca gcgagacggc cuggcgccgc ugccucuggc      420

gaacgcgacg auagagggcc cccugcuagc guggccgccc ugcgguccaa uuucgagcgc      480

auuagaaagg gacacggcca gcccggggcu gacgcggaaa agcccuuuua cgucaacgug      540

gaguuccauc acgagcgggg acuuguuaaa gugaaugaua aggaagucag cgacagaauc      600

ucuucccugg gcagccaagc caugcagaug gagcgcaaaa agucucagca uggggcugga      660

uccagcgugg gcgaugccuc ucggccuccg uauagaggcc gcuccagcga auccucuugu      720

gggguugacg gagacuacga ggaugccgaa cucaaccccc gguuucugaa agacaaucug      780

auugaugcua acggcgggag cagaccuccc uggccucccc ucgaguauca gccguaccaa      840

uccaucuaug ugggaggcau gauggagggg gaaggaaagg gcccucugcu ucgcagccag      900

ucuacguccg agcaggaaaa gcggcugacc uggcccagac gcagcuacuc uccucggagc      960

uucgaggacu gcggcggggg auacacaccc gauuguuccu cuaaugaaaa ccucaccagc     1020

uccgaggagg acuuuagcuc uggccaaucc agcagagucu cuccuucccc cacaaccuau     1080

cggauguucc gcgauaaaag cagauccccg ucucagaaua gccagcaguc cuuugacucu     1140

agcuccccuc ccacacccca augccacaag cggcauagac acuguccugu gguggucagc     1200

gaagccaccu cugggcagug a                                               1221


<210>  629
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  beta-catenin/m__Homo_sapiens__P35222

<400>  629

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  630
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  beta-catenin/m__Homo_sapiens__AAH58926

<400>  630
auggcuacuc aagcugauuu gauggaguug gacauggcca uggaaccaga cagaaaagcg       60

gcuguuaguc acuggcagca acagucuuac cuggacucug gaauccauuc uggugccacu      120

accacagcuc cuucucugag ugguaaaggc aauccugagg aagaggaugu ggauaccucc      180

caaguccugu augaguggga acagggauuu ucucaguccu ucacucaaga acaaguagcu      240

gauauugaug gacaguaugc aaugacucga gcucagaggg uacgagcugc uauguucccu      300

gagacauuag augagggcau gcagauccca ucuacacagu uugaugcugc ucaucccacu      360

aauguccagc guuuggcuga accaucacag augcugaaac augcaguugu aaacuugauu      420

aacuaucaag augaugcaga acuugccaca cgugcaaucc cugaacugac aaaacugcua      480

aaugacgagg accagguggu gguuaauaag gcugcaguua ugguccauca gcuuucuaaa      540

aaggaagcuu ccagacacgc uaucaugcgu ucuccucaga uggugucugc uauuguacgu      600

accaugcaga auacaaauga uguagaaaca gcucguugua ccgcugggac cuugcauaac      660

cuuucccauc aucgugaggg cuuacuggcc aucuuuaagu cuggaggcau uccugcccug      720

gugaaaaugc uugguucacc aguggauucu guguuguuuu augccauuac aacucuccac      780

aaccuuuuau uacaucaaga aggagcuaaa auggcagugc guuuagcugg ugggcugcag      840

aaaaugguug ccuugcucaa caaaacaaau guuaaauucu uggcuauuac gacagacugc      900

cuucaaauuu uagcuuaugg caaccaagaa agcaagcuca ucauacuggc uaguggugga      960

ccccaagcuu uaguaaauau aaugaggacc uauacuuacg aaaaacuacu guggaccaca     1020

agcagagugc ugaaggugcu aucugucugc ucuaguaaua agccggcuau uguagaagcu     1080

gguggaaugc aagcuuuagg acuucaccug acagauccaa gucaacgucu uguucagaac     1140

ugucuuugga cucucaggaa ucuuucagau gcugcaacua aacaggaagg gauggaaggu     1200

cuccuuggga cucuuguuca gcuucugggu ucagaugaua uaaauguggu caccugugca     1260

gcuggaauuc uuucuaaccu cacuugcaau aauuauaaga acaagaugau ggucugccaa     1320

guggguggua uagaggcucu ugugcguacu guccuucggg cuggugacag ggaagacauc     1380

acugagccug ccaucugugc ucuucgucau cugaccagcc gacaccaaga agcagagaug     1440

gcccagaaug caguucgccu ucacuaugga cuaccaguug ugguuaagcu cuuacaccca     1500

ccaucccacu ggccucugau aaaggcuacu guuggauuga uucgaaaucu ugcccuuugu     1560

cccgcaaauc augcaccuuu gcgugagcag ggugccauuc cacgacuagu ucaguugcuu     1620

guucgugcac aucaggauac ccagcgccgu acguccaugg gugggacaca gcagcaauuu     1680

guggaggggg uccgcaugga agaaauaguu gaagguugua ccggagcccu ucacauccua     1740

gcucgggaug uucacaaccg aauuguuauc agaggacuaa auaccauucc auuguuugug     1800

cagcugcuuu auucucccau ugaaaacauc caaagaguag cugcaggggu ccucugugaa     1860

cuugcucagg acaaggaagc ugcagaagcu auugaagcug agggagccac agcuccucug     1920

acagaguuac uucacucuag gaaugaaggu guggcgacau augcagcugc uguuuuguuc     1980

cgaaugucug aggacaagcc acaagauuac aagaaacggc uuucaguuga gcugaccagc     2040

ucucucuuca gaacagagcc aauggcuugg aaugagacug cugaucuugg acuugauauu     2100

ggugcccagg gagaaccccu uggauaucgc caggaugauc cuagcuaucg uucuuuucac     2160

ucugguggau auggccagga ugccuugggu auggacccca ugauggaaca ugagaugggu     2220

ggccaccacc cuggugcuga cuauccaguu gaugggcugc cagaucuggg gcaugcccag     2280

gaccucaugg augggcugcc uccaggugac agcaaucagc uggccugguu ugauacugac     2340

cuguaa                                                                2346


<210>  631
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       beta-catenin/m__Homo_sapiens__AAH58926

<400>  631
auggccaccc aggccgaccu gauggagcuc gacauggcga uggagcccga ccgcaaggcc       60

gccgugagcc acuggcagca gcaguccuac cuggacagcg gcauccacuc cggggccacc      120

acgaccgccc ccagccuguc cggcaagggg aaccccgagg aggaggacgu cgacaccagc      180

caggugcucu acgaguggga gcagggcuuc ucccagagcu ucacccagga gcaggucgcg      240

gacaucgacg ggcaguacgc caugacgcgg gcccagcgcg ugcgggccgc gauguucccc      300

gagacccugg acgagggcau gcagaucccc uccacccagu ucgacgccgc ccacccgacc      360

aacgugcagc gccuggccga gcccagccag augcucaagc acgccguggu caaccugauc      420

aacuaccagg acgacgcgga gcuggccacg cgggccaucc ccgagcucac caagcugcug      480

aacgacgagg accagguggu ggucaacaag gccgccguga uggugcacca gcucuccaag      540

aaggaggcga gccgccacgc caucaugcgg agcccccaga uggucuccgc caucgugcgc      600

accaugcaga acaccaacga cguggagacg gcccggugca ccgccggcac ccugcacaac      660

cugucccacc accgcgaggg gcuccuggcg aucuucaaga gcggcgggau cccggcccug      720

gucaagaugc ucggcucccc cguggacagc gugcuguucu acgccaucac cacgcugcac      780

aaccuccugc ugcaccagga gggggccaag auggccgucc ggcucgcggg cggccugcag      840

aagauggugg cccugcucaa caagaccaac gugaaguucc uggccaucac caccgacugc      900

cugcagaucc ucgccuacgg gaaccaggag uccaagcuga ucauccuggc gagcggcggg      960

ccccaggccc ucgucaacau caugcgcacg uacaccuacg agaagcugcu guggaccacc     1020

agccgggugc ucaaggugcu guccgucugc agcuccaaca agcccgccau cguggaggcc     1080

ggcggcaugc aggcccuggg gcuccaccug acggacccga gccagcgccu gguccagaac     1140

ugccucugga cccugcggaa ccuguccgac gcggccacca agcaggaggg cauggagggg     1200

cuccugggca cccuggugca gcuccugggg agcgacgaca ucaacguggu cacgugcgcc     1260

gccggcaucc uguccaaccu gaccugcaac aacuacaaga acaagaugau ggugugccag     1320

gugggcggga ucgaggcccu cguccgcacc gugcugcggg cgggcgaccg cgaggacauc     1380

accgagcccg ccaucugcgc ccugcggcac cucacgagcc gccaccagga ggccgagaug     1440

gcccagaacg cggugcggcu gcacuacggg cugcccgucg uggugaagcu ccugcacccg     1500

cccucccacu ggccccugau caaggccacc gucggccuca uccgcaaccu ggcccugugc     1560

cccgccaacc acgcgccccu ccgcgagcag ggggccaucc cgcggcuggu gcagcugcuc     1620

gugcgcgccc accaggacac ccagcggcgc accagcaugg gcggcacgca gcagcaguuc     1680

gucgaggggg ugcggaugga ggagaucgug gagggcugca ccggggcccu gcacauccug     1740

gcccgcgacg uccacaaccg gaucgugauc cgcggccuca acaccauccc ccuguucgug     1800

cagcugcucu acucccccau cgagaacauc cagcgggucg cggccggggu gcugugcgag     1860

cuggcccagg acaaggaggc cgccgaggcg aucgaggccg agggcgccac cgcgccccuc     1920

accgagcugc ugcacagccg caacgagggc guggccacgu acgccgccgc cguccucuuc     1980

cggauguccg aggacaagcc gcaggacuac aagaagcgcc ugagcgugga gcugaccucc     2040

agccucuucc ggaccgagcc cauggccugg aacgagaccg cggaccuggg gcuggacauc     2100

ggcgcccagg gggagccccu cggcuaccgc caggacgacc ccuccuaccg gagcuuccac     2160

uccggcgggu acggccagga cgcccugggg auggacccga ugauggagca cgagaugggc     2220

gggcaccacc ccggcgccga cuaccccgug gacggccugc cggaccucgg gcacgcccag     2280

gaccugaugg acggccugcc gcccggggac agcaaccagc ucgcgugguu cgacacggac     2340

cuguga                                                                2346


<210>  632
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       beta-catenin/m__Homo_sapiens__AAH58926

<400>  632
auggccaccc aggccgaccu cauggagcuc gacauggcca uggagcccga ccgcaaggcc       60

gccgucuccc acuggcagca gcaguccuac cucgacuccg gcauccacuc cggcgccacc      120

accaccgccc ccucccucuc cggcaagggc aaccccgagg aggaggacgu cgacaccucc      180

cagguccucu acgaguggga gcagggcuuc ucccaguccu ucacccagga gcaggucgcc      240

gacaucgacg gccaguacgc caugacccgc gcccagcgcg uccgcgccgc cauguucccc      300

gagacccucg acgagggcau gcagaucccc uccacccagu ucgacgccgc ccaccccacc      360

aacguccagc gccucgccga gcccucccag augcucaagc acgccgucgu caaccucauc      420

aacuaccagg acgacgccga gcucgccacc cgcgccaucc ccgagcucac caagcuccuc      480

aacgacgagg accaggucgu cgucaacaag gccgccguca ugguccacca gcucuccaag      540

aaggaggccu cccgccacgc caucaugcgc uccccccaga uggucuccgc caucguccgc      600

accaugcaga acaccaacga cgucgagacc gcccgcugca ccgccggcac ccuccacaac      660

cucucccacc accgcgaggg ccuccucgcc aucuucaagu ccggcggcau ccccgcccuc      720

gucaagaugc ucggcucccc cgucgacucc guccucuucu acgccaucac cacccuccac      780

aaccuccucc uccaccagga gggcgccaag auggccgucc gccucgccgg cggccuccag      840

aagauggucg cccuccucaa caagaccaac gucaaguucc ucgccaucac caccgacugc      900

cuccagaucc ucgccuacgg caaccaggag uccaagcuca ucauccucgc cuccggcggc      960

ccccaggccc ucgucaacau caugcgcacc uacaccuacg agaagcuccu cuggaccacc     1020

ucccgcgucc ucaagguccu cuccgucugc uccuccaaca agcccgccau cgucgaggcc     1080

ggcggcaugc aggcccucgg ccuccaccuc accgaccccu cccagcgccu cguccagaac     1140

ugccucugga cccuccgcaa ccucuccgac gccgccacca agcaggaggg cauggagggc     1200

cuccucggca cccucgucca gcuccucggc uccgacgaca ucaacgucgu caccugcgcc     1260

gccggcaucc ucuccaaccu caccugcaac aacuacaaga acaagaugau ggucugccag     1320

gucggcggca ucgaggcccu cguccgcacc guccuccgcg ccggcgaccg cgaggacauc     1380

accgagcccg ccaucugcgc ccuccgccac cucaccuccc gccaccagga ggccgagaug     1440

gcccagaacg ccguccgccu ccacuacggc cuccccgucg ucgucaagcu ccuccacccc     1500

cccucccacu ggccccucau caaggccacc gucggccuca uccgcaaccu cgcccucugc     1560

cccgccaacc acgccccccu ccgcgagcag ggcgccaucc cccgccucgu ccagcuccuc     1620

guccgcgccc accaggacac ccagcgccgc accuccaugg gcggcaccca gcagcaguuc     1680

gucgagggcg uccgcaugga ggagaucguc gagggcugca ccggcgcccu ccacauccuc     1740

gcccgcgacg uccacaaccg caucgucauc cgcggccuca acaccauccc ccucuucguc     1800

cagcuccucu acucccccau cgagaacauc cagcgcgucg ccgccggcgu ccucugcgag     1860

cucgcccagg acaaggaggc cgccgaggcc aucgaggccg agggcgccac cgccccccuc     1920

accgagcucc uccacucccg caacgagggc gucgccaccu acgccgccgc cguccucuuc     1980

cgcauguccg aggacaagcc ccaggacuac aagaagcgcc ucuccgucga gcucaccucc     2040

ucccucuucc gcaccgagcc cauggccugg aacgagaccg ccgaccucgg ccucgacauc     2100

ggcgcccagg gcgagccccu cggcuaccgc caggacgacc ccuccuaccg cuccuuccac     2160

uccggcggcu acggccagga cgcccucggc auggacccca ugauggagca cgagaugggc     2220

ggccaccacc ccggcgccga cuaccccguc gacggccucc ccgaccucgg ccacgcccag     2280

gaccucaugg acggccuccc ccccggcgac uccaaccagc ucgccugguu cgacaccgac     2340

cucuga                                                                2346


<210>  633
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       beta-catenin/m__Homo_sapiens__AAH58926

<400>  633
auggccaccc aggcugaccu gauggagcuc gauauggcaa uggaacccga cagaaaggcc       60

gcggugagcc acuggcaaca gcaguccuac cuugauucug gcauccauuc aggggcuaca      120

acuacggccc cuagucugag cggaaaaggu aacccagagg aagaggacgu cgauaccucc      180

cagguuuugu augaauggga gcaaggcuuc ucucagucgu uuacacagga acagguggca      240

gacauugaug ggcaauacgc caugacuagg gcucagcggg uacgcgcagc cauguucccg      300

gagaccuuag acgagggaau gcagauaccc ucaacacagu uugaugcugc ccacccuacc      360

aaugugcaac gacuggcgga accaagccag augcuaaagc augcagucgu gaaccucauc      420

aauuaucagg acgaugccga gcuggcuacu cgugccauuc ccgagcuuac aaaacuguug      480

aacgacgaag aucaaguugu ggucaauaag gcagcuguga ugguacacca gcucaguaaa      540

aaggaggccu ccagacaugc gaucaugagg ucuccucaga ugguuagcgc cauugugcgg      600

accaugcaga acacgaauga cgucgaaacu gcacgcugca ccgcuggcac acugcacaac      660

cugucccacc auagagaggg ucucuuagcc aucuucaagu cagggggaau accagcucug      720

gugaaaaugc uuggcagucc cguggacagc gucuuguuuu acgccaucac uacccugcac      780

aaucuacucc ugcaucaaga aggcgcaaag auggccguua ggcuugcugg gggacugcag      840

aaaauggugg cguugcucaa caagacaaau guaaaauucc uggcaauuac cacggauugu      900

uuacagaucc uggccuaugg uaaccaggag ucuaagcuca uuauccuugc uuccggcggg      960

ccucaagccc uggugaauau aaugcggacu uacacauaug agaaguugcu auggaccacu     1020

ucacgcgucc ugaaagugcu cagcguuugc aguucuaaca agccagcaau uguggaagcc     1080

ggaggcaugc aggcucuggg ucuucaccug acagacccgu cccagcgauu gguccagaau     1140

ugucucugga cccugagaaa cuuaagcgau gccgcaacga aacaagaggg gauggaagga     1200

cugcuaggca cccucgugca gcugcuuggc ucggacgaua ucaacguagu uacaugcgcg     1260

gcugggauuu ugucuaaucu gacuuguaac aauuacaaga acaaaaugau ggugugccag     1320

gucggaggua ucgaggcccu cgugaggacc guccugcggg caggcgaccg ugaagauauc     1380

acagagcccg ccauuugugc ucuuagacac cugacuucca gacaucagga ggccgaaaug     1440

gcacaaaaug cugugagguu gcacuacggg cucccuguug ugguaaagcu guuacaucca     1500

cccucacacu ggccucugau aaaagccacc gucggacuaa uccggaaccu cgcgcugugc     1560

ccagccaauc augcuccccu ucgagagcag ggcgcaauuc cgcgcuuggu gcagcugcuc     1620

guuagagccc accaagacac acagaggcgg accaguaugg gugggacuca gcagcaauuu     1680

guggaaggcg uccgcaugga ggaaaucgug gagggaugua cgggcgcucu gcacauauua     1740

gccagagaug uacauaacag gauugugauc cgugggcuga auacaauccc ucuuuucguu     1800

caguugcucu auagccccau ugagaacauc cagcgggucg cagcgggagu gcugugcgaa     1860

cuagcccagg acaaggaggc ugccgaagca auugaggcug agggugccac cgcaccacug     1920

acugaacucc ugcacucccg aaaugagggc guggccaccu acgcugcggc cguccuuuuu     1980

agaaugucug aagauaagcc ucaagacuau aaaaagaggu ugagcguuga gcugacauca     2040

aguuuauucc gcaccgaacc cauggcaugg aacgagacug cugaccucgg gcuggauaua     2100

ggagcccagg gcgagccacu ugguuaccgg caggacgauc ccuccuaucg cagcuuucau     2160

ucugggggcu acggacagga cgcccugggc auggauccua ugauggaaca cgagauggga     2220

gggcaccauc caggugcuga cuauccggug gauggcuugc ccgaccucgg gcacgcacaa     2280

gaucugaugg acggacuacc uccaggcgau ucaaaucagc uggccugguu cgacacagau     2340

cucuga                                                                2346


<210>  634
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       beta-catenin/m__Homo_sapiens__AAH58926

<400>  634
auggccaccc aggccgaccu gauggagcug gacauggcca uggagcccga cagaaaggcc       60

gccgugagcc acuggcagca gcagagcuac cuggacagcg gcauccacag cggcgccacc      120

accaccgccc ccagccugag cggcaagggc aaccccgagg aggaggacgu ggacaccagc      180

caggugcugu acgaguggga gcagggcuuc agccagagcu ucacccagga gcagguggcc      240

gacaucgacg gccaguacgc caugaccaga gcccagagag ugagagccgc cauguucccc      300

gagacccugg acgagggcau gcagaucccc agcacccagu ucgacgccgc ccaccccacc      360

aacgugcaga gacuggccga gcccagccag augcugaagc acgccguggu gaaccugauc      420

aacuaccagg acgacgccga gcuggccacc agagccaucc ccgagcugac caagcugcug      480

aacgacgagg accagguggu ggugaacaag gccgccguga uggugcacca gcugagcaag      540

aaggaggcca gcagacacgc caucaugaga agcccccaga uggugagcgc caucgugaga      600

accaugcaga acaccaacga cguggagacc gccagaugca ccgccggcac ccugcacaac      660

cugagccacc acagagaggg ccugcuggcc aucuucaaga gcggcggcau ccccgcccug      720

gugaagaugc ugggcagccc cguggacagc gugcuguucu acgccaucac cacccugcac      780

aaccugcugc ugcaccagga gggcgccaag auggccguga gacuggccgg cggccugcag      840

aagauggugg cccugcugaa caagaccaac gugaaguucc uggccaucac caccgacugc      900

cugcagaucc uggccuacgg caaccaggag agcaagcuga ucauccuggc cagcggcggc      960

ccccaggccc uggugaacau caugagaacc uacaccuacg agaagcugcu guggaccacc     1020

agcagagugc ugaaggugcu gagcgugugc agcagcaaca agcccgccau cguggaggcc     1080

ggcggcaugc aggcccuggg ccugcaccug accgacccca gccagagacu ggugcagaac     1140

ugccugugga cccugagaaa ccugagcgac gccgccacca agcaggaggg cauggagggc     1200

cugcugggca cccuggugca gcugcugggc agcgacgaca ucaacguggu gaccugcgcc     1260

gccggcaucc ugagcaaccu gaccugcaac aacuacaaga acaagaugau ggugugccag     1320

gugggcggca ucgaggcccu ggugagaacc gugcugagag ccggcgacag agaggacauc     1380

accgagcccg ccaucugcgc ccugagacac cugaccagca gacaccagga ggccgagaug     1440

gcccagaacg ccgugagacu gcacuacggc cugcccgugg uggugaagcu gcugcacccc     1500

cccagccacu ggccccugau caaggccacc gugggccuga ucagaaaccu ggcccugugc     1560

cccgccaacc acgccccccu gagagagcag ggcgccaucc ccagacuggu gcagcugcug     1620

gugagagccc accaggacac ccagagaaga accagcaugg gcggcaccca gcagcaguuc     1680

guggagggcg ugagaaugga ggagaucgug gagggcugca ccggcgcccu gcacauccug     1740

gccagagacg ugcacaacag aaucgugauc agaggccuga acaccauccc ccuguucgug     1800

cagcugcugu acagccccau cgagaacauc cagagagugg ccgccggcgu gcugugcgag     1860

cuggcccagg acaaggaggc cgccgaggcc aucgaggccg agggcgccac cgccccccug     1920

accgagcugc ugcacagcag aaacgagggc guggccaccu acgccgccgc cgugcuguuc     1980

agaaugagcg aggacaagcc ccaggacuac aagaagagac ugagcgugga gcugaccagc     2040

agccuguuca gaaccgagcc cauggccugg aacgagaccg ccgaccuggg ccuggacauc     2100

ggcgcccagg gcgagccccu gggcuacaga caggacgacc ccagcuacag aagcuuccac     2160

agcggcggcu acggccagga cgcccugggc auggacccca ugauggagca cgagaugggc     2220

ggccaccacc ccggcgccga cuaccccgug gacggccugc ccgaccuggg ccacgcccag     2280

gaccugaugg acggccugcc ccccggcgac agcaaccagc uggccugguu cgacaccgac     2340

cuguga                                                                2346


<210>  635
<211>  2346
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       beta-catenin/m__Homo_sapiens__AAH58926

<400>  635
auggccaccc aggcugaccu gauggagcuc gauauggcca uggaacccga cagaaaggcg       60

gcugugagcc acuggcaaca gcaguccuac cuggauucug gcauccauag cggggccaca      120

acgaccgccc cuucccuuuc uggaaaaggc aacccggagg aagaggacgu cgauacaagc      180

cagguucugu augaauggga gcaaggguuc ucccagucuu uuacccagga acagguggcu      240

gacauugaug gacaauacgc caugacacgg gcucagcgcg ugagagccgc gauguucccc      300

gagacccucg acgagggcau gcagaucccu agcacacagu uugaugccgc ucaccccacc      360

aauguccaac ggcuggccga accuucccag augcuuaagc augcuguggu uaaccugauu      420

aauuaucagg acgaugccga gcucgcgacg cgcgccaucc ccgagcugac caaacugcuc      480

aacgacgaag aucaaguggu cgugaauaag gcugccguua uggugcacca gcugagcaaa      540

aaggaggcuu cuagacaugc cauuaugcgg uccccucaga uggucagcgc caucgugcgc      600

acaaugcaga acaccaauga cguggaaaca gcuagaugca ccgcggggac gcuucacaac      660

cugucucacc aucgggaggg acuccuggcc aucuucaagu ccggcggcau uccggcucuu      720

gucaaaaugc uggggagccc cguugacucu gugcucuuuu acgccaucac aacccugcac      780

aaucugcucc ugcaucaaga aggagccaag auggcugugc gccuugccgg cgggcugcag      840

aaaauggucg cgcuccugaa caagacaaau gugaaauucc uugcuauuac caccgauugu      900

cugcagaucc ucgccuaugg aaaccaggag uccaagcuga uuauccuggc cagcggcggg      960

ccucaagcuc ucguuaauau uaugagaaca uacacguaug agaagcugcu uuggaccaca     1020

ucccgggugc ugaaaguccu cucugugugc agcuccaaca agcccgccau cguugaagcu     1080

ggaggcaugc aggcccuggg ccuucaccug accgacccua gccagcgccu cgugcagaau     1140

ugucugugga cacugagaaa ccucucugau gcggccacca aacaagaggg gauggaagga     1200

cugcuuggca cgcuggucca gcuccugggg uccgacgaua ucaacguggu cacaugcgcu     1260

gccggcauuc ugagcaaucu uaccuguaac aauuacaaga acaaaaugau ggugugccag     1320

guuggaggga ucgaggcucu cgugcggacc guccugcgcg ccggagacag agaagauauu     1380

acagagcccg cgaucugugc ccugcggcac cucaccucua gacaucagga ggcugaaaug     1440

gcccaaaaug cugugcgccu gcacuacggc cuuccgguug uggucaagcu gcuccauccu     1500

cccagccacu ggccucugau uaaagccaca gugggccuga uccggaaccu ugcccucugc     1560

cccgcuaauc augcgccccu gagagagcag ggggccaucc cucgccuggu gcagcuccug     1620

guucgggcuc accaagacac gcagagacgc accuccaugg gaggcacaca gcagcaauuu     1680

gucgaagggg ugcggaugga ggaaauugug gagggaugua ccggcgcccu ucacauccug     1740

gccagagaug uccauaaccg cauugugauc cgggggcuca auacaauucc gcuguucguu     1800

cagcugcuuu auucucccau cgagaacauc cagagagugg cugccggcgu ccucugcgaa     1860

cuggcgcagg acaaggaggc ugccgaagcc auugaggcug agggagccac cgcgccucug     1920

acggaacucc ugcacagccg caaugagggc guggcuaccu acgccgccgc uguucuuuuu     1980

cggauguccg aagauaagcc ccaagacuau aaaaagagac ugagcgugga gcucacaucu     2040

ucccuguucc ggaccgaacc uauggccugg aacgagacag cugaccuggg gcuugauauc     2100

ggagcccagg gcgagccccu cggguaccgc caggacgauc cgagcuauag aucuuuucau     2160

uccggaggcu acgggcagga cgcgcugggc auggauccua ugauggaaca cgagauggga     2220

ggccaccauc ccggggccga cuauccuguc gauggacugc ccgaccucgg ccacgcucaa     2280

gaucugaugg acgggcuucc ucccggagau agcaaucagc uggccugguu cgacaccgau     2340

cucuga                                                                2346


<210>  636
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  beta-catenin/m__Homo_sapiens__Q8WYA6

<400>  636

Met Asp Val Gly Glu Leu Leu Ser Tyr Gln Pro Asn Arg Gly Thr Lys 
1               5                   10                  15      


Arg Pro Arg Asp Asp Glu Glu Glu Glu Gln Lys Met Arg Arg Lys Gln 
            20                  25                  30          


Thr Gly Thr Arg Glu Arg Gly Arg Tyr Arg Glu Glu Glu Met Thr Val 
        35                  40                  45              


Val Glu Glu Ala Asp Asp Asp Lys Lys Arg Leu Leu Gln Ile Ile Asp 
    50                  55                  60                  


Arg Asp Gly Glu Glu Glu Glu Glu Glu Glu Glu Pro Leu Asp Glu Ser 
65                  70                  75                  80  


Ser Val Lys Lys Met Ile Leu Thr Phe Glu Lys Arg Ser Tyr Lys Asn 
                85                  90                  95      


Gln Glu Leu Arg Ile Lys Phe Pro Asp Asn Pro Glu Lys Phe Met Glu 
            100                 105                 110         


Ser Glu Leu Asp Leu Asn Asp Ile Ile Gln Glu Met His Val Val Ala 
        115                 120                 125             


Thr Met Pro Asp Leu Tyr His Leu Leu Val Glu Leu Asn Ala Val Gln 
    130                 135                 140                 


Ser Leu Leu Gly Leu Leu Gly His Asp Asn Thr Asp Val Ser Ile Ala 
145                 150                 155                 160 


Val Val Asp Leu Leu Gln Glu Leu Thr Asp Ile Asp Thr Leu His Glu 
                165                 170                 175     


Ser Glu Glu Gly Ala Glu Val Leu Ile Asp Ala Leu Val Asp Gly Gln 
            180                 185                 190         


Val Val Ala Leu Leu Val Gln Asn Leu Glu Arg Leu Asp Glu Ser Val 
        195                 200                 205             


Lys Glu Glu Ala Asp Gly Val His Asn Thr Leu Ala Ile Val Glu Asn 
    210                 215                 220                 


Met Ala Glu Phe Arg Pro Glu Met Cys Thr Glu Gly Ala Gln Gln Gly 
225                 230                 235                 240 


Leu Leu Gln Trp Leu Leu Lys Arg Leu Lys Ala Lys Met Pro Phe Asp 
                245                 250                 255     


Ala Asn Lys Leu Tyr Cys Ser Glu Val Leu Ala Ile Leu Leu Gln Asp 
            260                 265                 270         


Asn Asp Glu Asn Arg Glu Leu Leu Gly Glu Leu Asp Gly Ile Asp Val 
        275                 280                 285             


Leu Leu Gln Gln Leu Ser Val Phe Lys Arg His Asn Pro Ser Thr Ala 
    290                 295                 300                 


Glu Glu Gln Glu Met Met Glu Asn Leu Phe Asp Ser Leu Cys Ser Cys 
305                 310                 315                 320 


Leu Met Leu Ser Ser Asn Arg Glu Arg Phe Leu Lys Gly Glu Gly Leu 
                325                 330                 335     


Gln Leu Met Asn Leu Met Leu Arg Glu Lys Lys Ile Ser Arg Ser Ser 
            340                 345                 350         


Ala Leu Lys Val Leu Asp His Ala Met Ile Gly Pro Glu Gly Thr Asp 
        355                 360                 365             


Asn Cys His Lys Phe Val Asp Ile Leu Gly Leu Arg Thr Ile Phe Pro 
    370                 375                 380                 


Leu Phe Met Lys Ser Pro Arg Lys Ile Lys Lys Val Gly Thr Thr Glu 
385                 390                 395                 400 


Lys Glu His Glu Glu His Val Cys Ser Ile Leu Ala Ser Leu Leu Arg 
                405                 410                 415     


Asn Leu Arg Gly Gln Gln Arg Thr Arg Leu Leu Asn Lys Phe Thr Glu 
            420                 425                 430         


Asn Asp Ser Glu Lys Val Asp Arg Leu Met Glu Leu His Phe Lys Tyr 
        435                 440                 445             


Leu Gly Ala Met Gln Val Ala Asp Lys Lys Ile Glu Gly Glu Lys His 
    450                 455                 460                 


Asp Met Val Arg Arg Gly Glu Ile Ile Asp Asn Asp Thr Glu Glu Glu 
465                 470                 475                 480 


Phe Tyr Leu Arg Arg Leu Asp Ala Gly Leu Phe Val Leu Gln His Ile 
                485                 490                 495     


Cys Tyr Ile Met Ala Glu Ile Cys Asn Ala Asn Val Pro Gln Ile Arg 
            500                 505                 510         


Gln Arg Val His Gln Ile Leu Asn Met Arg Gly Ser Ser Ile Lys Ile 
        515                 520                 525             


Val Arg His Ile Ile Lys Glu Tyr Ala Glu Asn Ile Gly Asp Gly Arg 
    530                 535                 540                 


Ser Pro Glu Phe Arg Glu Asn Glu Gln Lys Arg Ile Leu Gly Leu Leu 
545                 550                 555                 560 


Glu Asn Phe 
            


<210>  637
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  beta-catenin/m__Homo_sapiens__AAI21007

<400>  637
auggacgugg gcgaacuucu gagcuaccag cccaauaggg gcacaaaacg uccccgggau       60

gaugaagagg aggagcagaa gaugcgucgg aaacaaacug guacucgaga acgcggccgc      120

uaucgggaag aagaaaugac ugugguggag gaagcggaug augacaaaaa aaggcugcug      180

cagauuauug acagagaugg ggaagaggaa gaggaagagg aggagccauu ggaugaaagc      240

ucagugaaga aaaugauccu cacauuugaa aagagaucau auaaaaacca agaauugcgg      300

auuaaguuuc cagacaaucc agagaaguuc auggaauccg agcuggaccu aaaugacauc      360

auucaggaga ugcacguggu ggccaccaug ccagaccugu accaccuucu gguggagcug      420

aaugcuguac agucgcuucu cggcuugcuc ggacacgaua auacagaugu guccauagcu      480

guggucgauu ugcuucagga auuaacagau auagacaccc uccaugagag ugaagaggga      540

gcagaagugc ucaucgaugc ucugguggau gggcaggugg uagcacugcu gguacagaau      600

cuggagcgcc uggaugaguc ugugaaagag gaggcagaug gcguccacaa cacucuggcu      660

auuguggaaa acauggcuga guuccggccu gagaugugua cagagggugc ccagcagggu      720

cuucuacagu ggcuguugaa gaggcugaag gcaaagaugc cuuuugaugc caacaaacug      780

uauugcagug aagugcuggc cauauugcuc caggacaaug augaaaacag ggaauugcuu      840

ggggagcugg auggaaucga ugugcuucuu cagcaguuau ccguguuuaa aagacacaau      900

cccagcacgg cugaggagca ggagaugaug gagaaucugu uugauucccu cugcuccugu      960

cuaaugcuua guuccaaucg ugagcgcuuc cugaagggcg agggucuuca gcugaugaau     1020

cucaugcuca gggaaaagaa gaucucccgg agcagugccc ugaaagugcu ggaccaugcc     1080

augauuggcc ccgaaggcac agacaacugc cauaaguuug uugacauucu uggcuuacga     1140

accaucuuuc cccucuuuau gaaaucuccc aggaagauca agaaaguggg aaccacugag     1200

aaggaacaug aagagcaugu cuguucgauc cuggcuuccc uccugcggaa ccugagaggg     1260

cagcagcgga cccggcuucu gaauaaauuc acugaaaaug acagugagaa gguugacaga     1320

cuaauggagu ugcauuuuaa auaucugggu gcaaugcagg uggcggacaa gaagauugaa     1380

ggggaaaaac acgacauggu ccggcgagga gagaucaucg acaaugacac cgaggaggag     1440

uucuaccucc ggcgccugga ugcggggcuc uuuguucucc agcacaucug cuacaucaug     1500

gccgagaucu gcaaugccaa ugucccccag auucgccaga ggguucacca gauccuaaac     1560

augcgaggaa gcuccaucaa aauugucagg cauaucauca aggaguaugc agagaacauc     1620

ggggacggcc ggagcccgga guuccgggag aacgagcaaa agcgcauccu gggcuugcug     1680

gagaacuucu ag                                                         1692


<210>  638
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       beta-catenin/m__Homo_sapiens__AAI21007

<400>  638
auggacgugg gcgagcugcu cagcuaccag cccaaccgcg ggaccaagcg gccgcgcgac       60

gacgaggagg aggagcagaa gaugcggcgc aagcagaccg gcacgcggga gcgcgggcgg      120

uaccgcgagg aggagaugac cgucguggag gaggccgacg acgacaagaa gcggcugcug      180

cagaucaucg accgcgacgg cgaggaggag gaggaggagg aggagccccu cgacgagucc      240

agcgugaaga agaugauccu gaccuucgag aagcgguccu acaagaacca ggagcugcgc      300

aucaaguucc ccgacaaccc cgagaaguuc auggagagcg agcucgaccu gaacgacauc      360

auccaggaga ugcacgucgu ggccaccaug ccggaccugu accaccuccu gguggagcug      420

aacgcggucc agucccuccu ggggcugcuc ggccacgaca acacggacgu gagcaucgcc      480

guggucgacc ugcugcagga gcucaccgac aucgacaccc ugcacgaguc cgaggagggc      540

gccgaggugc ugaucgacgc ccucguggac gggcaggucg uggcccugcu ggugcagaac      600

cucgagcggc uggacgagag cgucaaggag gaggcggacg gcgugcacaa cacccuggcc      660

aucguggaga acauggccga guuccgcccc gagaugugca cggagggggc ccagcagggc      720

cuccugcagu ggcugcucaa gcggcugaag gcgaagaugc ccuucgacgc caacaagcug      780

uacugcuccg agguccucgc cauccugcug caggacaacg acgagaaccg cgagcuccug      840

ggggagcugg acggcaucga cgugcuccug cagcagcuga gcguguucaa gcggcacaac      900

cccuccaccg ccgaggagca ggagaugaug gagaaccucu ucgacagccu gugcuccugc      960

cugaugcuca gcuccaaccg cgagcgguuc cugaagggcg aggggcugca gcucaugaac     1020

cugaugcugc gcgagaagaa gaucagccgg uccagcgccc ugaagguccu cgaccacgcg     1080

augaucggcc cggaggggac cgacaacugc cacaaguucg uggacauccu gggccugcgc     1140

accaucuucc cccucuucau gaaguccccg cgcaagauca agaagguggg cacgaccgag     1200

aaggagcacg aggagcacgu cugcagcauc cuggccagcc ugcuccggaa ccugcgcggg     1260

cagcagcgga cccgccugcu caacaaguuc accgagaacg acuccgagaa gguggaccgg     1320

cugauggagc ugcacuucaa guaccucggc gccaugcagg ucgccgacaa gaagaucgag     1380

ggggagaagc acgacauggu gcgccggggc gagaucaucg acaacgacac ggaggaggag     1440

uucuaccugc gccggcugga cgccggccuc uucgugcugc agcacaucug cuacaucaug     1500

gcggagaucu gcaacgccaa cgucccccag auccgccagc gggugcacca gauccugaac     1560

augcgcggga gcuccaucaa gaucgugcgg cacaucauca aggaguacgc cgagaacauc     1620

ggcgacgggc gcagccccga guuccgggag aacgagcaga agcgcauccu cggccugcug     1680

gagaacuucu ga                                                         1692


<210>  639
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       beta-catenin/m__Homo_sapiens__AAI21007

<400>  639
auggacgucg gcgagcuccu cuccuaccag cccaaccgcg gcaccaagcg cccccgcgac       60

gacgaggagg aggagcagaa gaugcgccgc aagcagaccg gcacccgcga gcgcggccgc      120

uaccgcgagg aggagaugac cgucgucgag gaggccgacg acgacaagaa gcgccuccuc      180

cagaucaucg accgcgacgg cgaggaggag gaggaggagg aggagccccu cgacgagucc      240

uccgucaaga agaugauccu caccuucgag aagcgcuccu acaagaacca ggagcuccgc      300

aucaaguucc ccgacaaccc cgagaaguuc auggaguccg agcucgaccu caacgacauc      360

auccaggaga ugcacgucgu cgccaccaug cccgaccucu accaccuccu cgucgagcuc      420

aacgccgucc agucccuccu cggccuccuc ggccacgaca acaccgacgu cuccaucgcc      480

gucgucgacc uccuccagga gcucaccgac aucgacaccc uccacgaguc cgaggagggc      540

gccgaggucc ucaucgacgc ccucgucgac ggccaggucg ucgcccuccu cguccagaac      600

cucgagcgcc ucgacgaguc cgucaaggag gaggccgacg gcguccacaa cacccucgcc      660

aucgucgaga acauggccga guuccgcccc gagaugugca ccgagggcgc ccagcagggc      720

cuccuccagu ggcuccucaa gcgccucaag gccaagaugc ccuucgacgc caacaagcuc      780

uacugcuccg agguccucgc cauccuccuc caggacaacg acgagaaccg cgagcuccuc      840

ggcgagcucg acggcaucga cguccuccuc cagcagcucu ccgucuucaa gcgccacaac      900

cccuccaccg ccgaggagca ggagaugaug gagaaccucu ucgacucccu cugcuccugc      960

cucaugcucu ccuccaaccg cgagcgcuuc cucaagggcg agggccucca gcucaugaac     1020

cucaugcucc gcgagaagaa gaucucccgc uccuccgccc ucaagguccu cgaccacgcc     1080

augaucggcc ccgagggcac cgacaacugc cacaaguucg ucgacauccu cggccuccgc     1140

accaucuucc cccucuucau gaaguccccc cgcaagauca agaaggucgg caccaccgag     1200

aaggagcacg aggagcacgu cugcuccauc cucgccuccc uccuccgcaa ccuccgcggc     1260

cagcagcgca cccgccuccu caacaaguuc accgagaacg acuccgagaa ggucgaccgc     1320

cucauggagc uccacuucaa guaccucggc gccaugcagg ucgccgacaa gaagaucgag     1380

ggcgagaagc acgacauggu ccgccgcggc gagaucaucg acaacgacac cgaggaggag     1440

uucuaccucc gccgccucga cgccggccuc uucguccucc agcacaucug cuacaucaug     1500

gccgagaucu gcaacgccaa cgucccccag auccgccagc gcguccacca gauccucaac     1560

augcgcggcu ccuccaucaa gaucguccgc cacaucauca aggaguacgc cgagaacauc     1620

ggcgacggcc gcucccccga guuccgcgag aacgagcaga agcgcauccu cggccuccuc     1680

gagaacuucu ga                                                         1692


<210>  640
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       beta-catenin/m__Homo_sapiens__AAI21007

<400>  640
auggacgugg gcgagcugcu cagcuaccag cccaacagag ggaccaagag gccucgggau       60

gacgaagagg aagaacagaa aaugcgccga aagcaaacag gaacucguga aagagguagg      120

uaucgggagg aggaaaugac ggucguugag gaagccgaug acgauaaaaa gcgccuucug      180

cagaucauug acagagaugg cgaggaggaa gaggaagagg aggagccauu ggacgagucc      240

ucugugaaaa agaugauauu aaccuucgaa aagaggucau acaaaaauca ggagcugcgg      300

aucaaguuuc cggauaaccc cgaaaaauuc auggagagug aacuagaccu caaugauauu      360

auccaagaga ugcacguagu ggcuacaaug ccugaccugu aucaucuucu ggucgaguug      420

aacgcagugc agagccuccu ggggcugcuc ggacacgaua auacugacgu uuccauugcc      480

guggucgacu uacugcagga acuuaccgau aucgacacau ugcaugaguc ugaagagggc      540

gcggaagugc ugauagaugc ucuaguagac ggucagguug uggcccuccu gguccaaaac      600

cuugagcgcc uggaugaguc ggugaaggaa gaggcagacg gggugcacaa uaccuuggcc      660

aucgucgaaa acauggcuga guuucgacca gagaugugca cugaaggagc acagcagggc      720

cuccugcagu gguuacugaa aagacucaag gccaagaugc ccuucgaugc uaauaaacuu      780

uacuguucag agguucuggc cauuuugcua caagacaacg augaaaauag ggagcugcuc      840

ggcgaacugg acgggaucga ugugcuucug cagcaguuga gcguauuuaa gcggcauaac      900

ccuaguacag cggaggagca agaaaugaug gagaaucucu ucgacucccu gugcucuugu      960

uuaaugcuga gcuccaaccg ugaacgcuuu cuaaaaggag agggucucca gcugaugaau     1020

cuuauguuga gagaaaagaa aauuucaagg aguagcgcac ugaaggugcu cgaccacgcc     1080

augaucggcc cagaggggac cgauaacugc cacaaauucg ucgacauacu gggacuucgg     1140

acgauuuuuc cccuguucau gaagucuccu cgaaagauca aaaagguggg cacuaccgag     1200

aaagaacaug aggaacacgu uuguuccauu uuggcuucac uccugcgcaa cuuaagaggu     1260

cagcagagga cacggcugcu aaauaaguuu acugagaacg auagcgaaaa aguggaccgc     1320

cucauggagc ugcauuucaa guaucuuggg gccaugcaag ucgcagauaa gaaaaucgag     1380

ggagaaaagc acgacauggu gagaaggggc gagaucauug auaaugacac cgaagaggag     1440

uuuuacuugc gucggcugga ugcuggccuc uucguacugc agcacauaug cuauaucaug     1500

gccgaaauuu guaacgcgaa uguuccacag auccgacaga gagugcauca aauauuaaac     1560

augaggggga guucuauuaa aaucguccgc cacaucauua aggaguacgc cgaaaauauc     1620

ggagacgguc gguccccgga guucagagaa aacgagcaga aaaggauucu gggccuuuug     1680

gagaauuuuu ga                                                         1692


<210>  641
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       beta-catenin/m__Homo_sapiens__AAI21007

<400>  641
auggacgugg gcgagcugcu gagcuaccag cccaacagag gcaccaagag acccagagac       60

gacgaggagg aggagcagaa gaugagaaga aagcagaccg gcaccagaga gagaggcaga      120

uacagagagg aggagaugac cgugguggag gaggccgacg acgacaagaa gagacugcug      180

cagaucaucg acagagacgg cgaggaggag gaggaggagg aggagccccu ggacgagagc      240

agcgugaaga agaugauccu gaccuucgag aagagaagcu acaagaacca ggagcugaga      300

aucaaguucc ccgacaaccc cgagaaguuc auggagagcg agcuggaccu gaacgacauc      360

auccaggaga ugcacguggu ggccaccaug cccgaccugu accaccugcu gguggagcug      420

aacgccgugc agagccugcu gggccugcug ggccacgaca acaccgacgu gagcaucgcc      480

gugguggacc ugcugcagga gcugaccgac aucgacaccc ugcacgagag cgaggagggc      540

gccgaggugc ugaucgacgc ccugguggac ggccaggugg uggcccugcu ggugcagaac      600

cuggagagac uggacgagag cgugaaggag gaggccgacg gcgugcacaa cacccuggcc      660

aucguggaga acauggccga guucagaccc gagaugugca ccgagggcgc ccagcagggc      720

cugcugcagu ggcugcugaa gagacugaag gccaagaugc ccuucgacgc caacaagcug      780

uacugcagcg aggugcuggc cauccugcug caggacaacg acgagaacag agagcugcug      840

ggcgagcugg acggcaucga cgugcugcug cagcagcuga gcguguucaa gagacacaac      900

cccagcaccg ccgaggagca ggagaugaug gagaaccugu ucgacagccu gugcagcugc      960

cugaugcuga gcagcaacag agagagauuc cugaagggcg agggccugca gcugaugaac     1020

cugaugcuga gagagaagaa gaucagcaga agcagcgccc ugaaggugcu ggaccacgcc     1080

augaucggcc ccgagggcac cgacaacugc cacaaguucg uggacauccu gggccugaga     1140

accaucuucc cccuguucau gaagagcccc agaaagauca agaagguggg caccaccgag     1200

aaggagcacg aggagcacgu gugcagcauc cuggccagcc ugcugagaaa ccugagaggc     1260

cagcagagaa ccagacugcu gaacaaguuc accgagaacg acagcgagaa gguggacaga     1320

cugauggagc ugcacuucaa guaccugggc gccaugcagg uggccgacaa gaagaucgag     1380

ggcgagaagc acgacauggu gagaagaggc gagaucaucg acaacgacac cgaggaggag     1440

uucuaccuga gaagacugga cgccggccug uucgugcugc agcacaucug cuacaucaug     1500

gccgagaucu gcaacgccaa cgugccccag aucagacaga gagugcacca gauccugaac     1560

augagaggca gcagcaucaa gaucgugaga cacaucauca aggaguacgc cgagaacauc     1620

ggcgacggca gaagccccga guucagagag aacgagcaga agagaauccu gggccugcug     1680

gagaacuucu ga                                                         1692


<210>  642
<211>  1692
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       beta-catenin/m__Homo_sapiens__AAI21007

<400>  642
auggacgugg gcgagcugcu cagcuaccag cccaacagag ggaccaagcg gccucgcgau       60

gacgaagagg aagaacagaa aaugagacgg aagcaaacag gaacgcgcga aagaggccgg      120

uaucgcgagg aggaaaugac cgucguugag gaagccgaug acgauaaaaa gagacugcuu      180

cagaucauug accgggaugg ggaggaggaa gaggaagagg aggagccgcu ggacgagucc      240

ucugugaaaa agaugauccu cacauucgaa aagcgcagcu acaaaaauca ggagcugaga      300

auuaaguuuc ccgauaaccc ugaaaaauuc auggaguccg aacuugaccu gaaugauauc      360

auucaagaga ugcacguggu cgcuaccaug cccgaccucu aucaucugcu gguggagcuc      420

aacgccguuc agucucugcu uggacugcuc ggccacgaua auacagacgu gagcaucgcg      480

gucguggacc ugcuucagga acugaccgau aucgacacac uccaugaguc cgaagagggg      540

gcugaaguuc ugauugaugc ccugguggac ggacaggucg uggcccuccu ggugcaaaac      600

cuugagcggc uggaugaguc ugucaaggaa gaggcugacg gcguucacaa uacccucgcc      660

aucguggaaa acauggcuga guuucgcccu gagaugugca cggaaggcgc ccagcagggg      720

cugcuucagu ggcugcucaa aagacugaag gcgaagaugc ccuucgaugc caauaaacug      780

uacuguagcg aggugcucgc uauucugcuu caagacaacg augaaaaucg ggagcugcuc      840

ggagaacugg acggcaucga uguccuucug cagcagcucu ccguguuuaa gcgccauaac      900

ccuagcaccg ccgaggagca agaaaugaug gagaaucugu ucgacucucu gugcuccugu      960

cucaugcuga gcucuaacag agaacgguuu cuuaaagggg agggacugca gcucaugaau     1020

cugaugcuga gagaaaagaa aauuucccgc agcucugcuc uuaagguucu cgaccacgcc     1080

augaucggcc cggaggggac agauaacugc cacaaauucg uggacauucu gggacugcgg     1140

accaucuuuc cccucuucau gaaguccccu agaaagauca aaaaggucgg cacaaccgag     1200

aaagaacaug aggaacacgu guguagcauu cuggcguccc uucugcgcaa ccuccggggc     1260

cagcagagaa cgcgccugcu gaauaaguuu acagagaacg auucugaaaa aguugaccgg     1320

cuuauggagc uccauuucaa guaucugggg gccaugcaag uggcugauaa gaaaaucgag     1380

ggagaaaagc acgacauggu cagacgcggc gagauuaucg auaaugacac cgaagaggag     1440

uuuuaccugc ggagacucga ugccgggcug uucgugcuuc agcacauuug cuauaucaug     1500

gcugaaaucu guaacgccaa ugucccccag auucgccagc gggugcauca aauccugaac     1560

augagaggaa gcuccauuaa aaucguucgg cacauuauca aggaguacgc cgaaaauauc     1620

ggcgacgggc gcagcccuga guucagagaa aacgagcaga aacggauucu cggacugcug     1680

gagaauuuuu ga                                                         1692


<210>  643
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BING-4__Homo_sapiens__O15213

<400>  643

Met Glu Thr Ala Pro Lys Pro Gly Lys Asp Val Pro Pro Lys Lys Asp 
1               5                   10                  15      


Lys Leu Gln Thr Lys Arg Lys Lys Pro Arg Arg Tyr Trp Glu Glu Glu 
            20                  25                  30          


Thr Val Pro Thr Thr Ala Gly Ala Ser Pro Gly Pro Pro Arg Asn Lys 
        35                  40                  45              


Lys Asn Arg Glu Leu Arg Pro Gln Arg Pro Lys Asn Ala Tyr Ile Leu 
    50                  55                  60                  


Lys Lys Ser Arg Ile Ser Lys Lys Pro Gln Val Pro Lys Lys Pro Arg 
65                  70                  75                  80  


Glu Trp Lys Asn Pro Glu Ser Gln Arg Gly Leu Ser Gly Thr Gln Asp 
                85                  90                  95      


Pro Phe Pro Gly Pro Ala Pro Val Pro Val Glu Val Val Gln Lys Phe 
            100                 105                 110         


Cys Arg Ile Asp Lys Ser Arg Lys Leu Pro His Ser Lys Ala Lys Thr 
        115                 120                 125             


Arg Ser Arg Leu Glu Val Ala Glu Ala Glu Glu Glu Glu Thr Ser Ile 
    130                 135                 140                 


Lys Ala Ala Arg Ser Glu Leu Leu Leu Ala Glu Glu Pro Gly Phe Leu 
145                 150                 155                 160 


Glu Gly Glu Asp Gly Glu Asp Thr Ala Lys Ile Cys Gln Ala Asp Ile 
                165                 170                 175     


Val Glu Ala Val Asp Ile Ala Ser Ala Ala Lys His Phe Asp Leu Asn 
            180                 185                 190         


Leu Arg Gln Phe Gly Pro Tyr Arg Leu Asn Tyr Ser Arg Thr Gly Arg 
        195                 200                 205             


His Leu Ala Phe Gly Gly Arg Arg Gly His Val Ala Ala Leu Asp Trp 
    210                 215                 220                 


Val Thr Lys Lys Leu Met Cys Glu Ile Asn Val Met Glu Ala Val Arg 
225                 230                 235                 240 


Asp Ile Arg Phe Leu His Ser Glu Ala Leu Leu Ala Val Ala Gln Asn 
                245                 250                 255     


Arg Trp Leu His Ile Tyr Asp Asn Gln Gly Ile Glu Leu His Cys Ile 
            260                 265                 270         


Arg Arg Cys Asp Arg Val Thr Arg Leu Glu Phe Leu Pro Phe His Phe 
        275                 280                 285             


Leu Leu Ala Thr Ala Ser Glu Thr Gly Phe Leu Thr Tyr Leu Asp Val 
    290                 295                 300                 


Ser Val Gly Lys Ile Val Ala Ala Leu Asn Ala Arg Ala Gly Arg Leu 
305                 310                 315                 320 


Asp Val Met Ser Gln Asn Pro Tyr Asn Ala Val Ile His Leu Gly His 
                325                 330                 335     


Ser Asn Gly Thr Val Ser Leu Trp Ser Pro Ala Met Lys Glu Pro Leu 
            340                 345                 350         


Ala Lys Ile Leu Cys His Arg Gly Gly Val Arg Ala Val Ala Val Asp 
        355                 360                 365             


Ser Thr Gly Thr Tyr Met Ala Thr Ser Gly Leu Asp His Gln Leu Lys 
    370                 375                 380                 


Ile Phe Asp Leu Arg Gly Thr Tyr Gln Pro Leu Ser Thr Arg Thr Leu 
385                 390                 395                 400 


Pro His Gly Ala Gly His Leu Ala Phe Ser Gln Arg Gly Leu Leu Val 
                405                 410                 415     


Ala Gly Met Gly Asp Val Val Asn Ile Trp Ala Gly Gln Gly Lys Ala 
            420                 425                 430         


Ser Pro Pro Ser Leu Glu Gln Pro Tyr Leu Thr His Arg Leu Ser Gly 
        435                 440                 445             


Pro Val His Gly Leu Gln Phe Cys Pro Phe Glu Asp Val Leu Gly Val 
    450                 455                 460                 


Gly His Thr Gly Gly Ile Thr Ser Met Leu Val Pro Gly Ala Gly Glu 
465                 470                 475                 480 


Pro Asn Phe Asp Gly Leu Glu Ser Asn Pro Tyr Arg Ser Arg Lys Gln 
                485                 490                 495     


Arg Gln Glu Trp Glu Val Lys Ala Leu Leu Glu Lys Val Pro Ala Glu 
            500                 505                 510         


Leu Ile Cys Leu Asp Pro Arg Ala Leu Ala Glu Val Asp Val Ile Ser 
        515                 520                 525             


Leu Glu Gln Gly Lys Lys Glu Gln Ile Glu Arg Leu Gly Tyr Asp Pro 
    530                 535                 540                 


Gln Ala Lys Ala Pro Phe Gln Pro Lys Pro Lys Gln Lys Gly Arg Ser 
545                 550                 555                 560 


Ser Thr Ala Ser Leu Val Lys Arg Lys Arg Lys Val Met Asp Glu Glu 
                565                 570                 575     


His Arg Asp Lys Val Arg Gln Ser Leu Gln Gln Gln His His Lys Glu 
            580                 585                 590         


Ala Lys Ala Lys Pro Thr Gly Ala Arg Pro Ser Ala Leu Asp Arg Phe 
        595                 600                 605             


Val Arg 
    610 


<210>  644
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BING-4__Homo_sapiens__CCDS4772.1

<400>  644
auggagacag cccccaagcc gggcaaggau gucccgccca agaaagacaa acuucagacc       60

aagagaaaga aaccgcggcg auacugggag gaagagaccg uuccgaccac agccggagcc      120

ucuccagggc cuccucguaa caagaagaau cgggagcucc guccucagag accaaaaaau      180

gcuuacaucu uaaagaaguc ucggaucucu aagaagccuc aggucccgaa gaaaccccga      240

gaauggaaga acccggaguc ccagcgcggc uuguccggga cccaagaucc auucccaggc      300

cccgcccccg ucccugugga agugguccag aaguucuguc gcauugacaa aucccgaaag      360

cuaccacauu cuaaagccaa aacucgaagc cgacuugagg uggcugaagc ugaggaagag      420

gaaacaagua ucaaagcugc ucguucugag cugcugcuug cugaagaacc uggguuucug      480

gaaggggagg auggggaaga cacagcaaag auaugccagg cugacauugu ggaggcugug      540

gacauugcaa gugcagccaa gcacuuugac uugaaucugc ggcaguuugg acccuacaga      600

cuaaacuacu cucgaacugg aagacaccug gcuuuuggag ggcgccgagg ucauguggcu      660

gcccuugauu ggguaacaaa gaagcuuaug ugcgagauca acgucaugga ggcggugcgg      720

gacauccggu uucuccauuc ugaggcacug cuugcuguug cucagaaccg cuggcuccac      780

aucuaugaca aucagggcau ugagcuccac uguauccgcc gcugugaccg aguaacacgg      840

cuugaguucc ugcccuucca cuuccuccug gcuacagcuu cagaaacagg guuucuaacc      900

uaccuggaug ugucaguggg gaagauugug gcagcucuga augcucgagc ugggcggcuc      960

gauguuauga gucagaaccc uuacaaugcc gucauccauc ucggacacag caaugguacu     1020

gugucuuuau ggaguccagc uaugaaggag ccacuggcaa agauucucug ucaucguggu     1080

gggguccggg cuguggcagu agauucuaca ggcacguaca uggccaccuc uggccuagac     1140

caccagcuga agaucuuuga cuugcgaggg acguaccagc cucugagcac ucggacccug     1200

ccccauggag cagggcaccu ggccuucucc cagaggggac ugcugguggc gggaaugggu     1260

gacguuguca acaucugggc agggcagggc aaggccagcc cacccucccu ugaacagccc     1320

uaccucaccc accggcucuc aggcccugug cauggccuuc aguucugccc cuuugaagau     1380

gugcuggggg uggggcacac ugggggcauc accagcaugc uggucccugg ggccggugag     1440

cccaacuucg auggccugga gaguaaucca uacagaagcc ggaagcagcg ccaggagugg     1500

gaggugaagg cccugcuaga gaagguaccu gcagagcuua uuugucugga cccacgagcc     1560

cuggccgagg uggaugucau cucccuggag cagggaaaga aggagcagau agagaggcug     1620

ggcuaugacc cgcaggcuaa ggcucccuuc cagccaaagc caaagcagaa gggccgcagc     1680

uccacggcaa gccuggugaa gaggaagagg aaggucaugg augaggaaca cagggacaag     1740

guccggcaga gccuucagca gcagcaucau aaggaggcga aggccaagcc cacgggggcc     1800

cggccaucug cccuggacag auuugugcgc uga                                  1833


<210>  645
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BING-4__Homo_sapiens__CCDS4772.1

<400>  645
auggagaccg cccccaagcc gggcaaggac gugccgccca agaaggacaa gcugcagacc       60

aagcgcaaga agccccggcg cuacugggag gaggagacgg uccccaccac cgccggggcg      120

agccccggcc cgccccggaa caagaagaac cgcgagcucc ggccccagcg ccccaagaac      180

gccuacaucc ugaagaaguc ccggaucagc aagaagcccc aggugcccaa gaagccgcgc      240

gaguggaaga accccgaguc ccagcggggg cugagcggca cccaggaccc cuuccccggg      300

ccggcccccg ugcccgucga gguggugcag aaguucugcc gcaucgacaa gucccggaag      360

cucccccaca gcaaggccaa gacgcgcucc cggcuggagg ucgccgaggc ggaggaggag      420

gagaccagca ucaaggccgc ccgcuccgag cugcuccugg ccgaggagcc gggcuuccug      480

gagggcgagg acggggagga caccgcgaag aucugccagg ccgacaucgu ggaggccgug      540

gacaucgcca gcgccgcgaa gcacuucgac cucaaccugc ggcaguucgg ccccuaccgc      600

cugaacuacu cccggaccgg gcgccaccuc gccuucggcg ggcggcgcgg ccacgucgcc      660

gcccuggacu gggugacgaa gaagcugaug ugcgagauca acgugaugga ggccguccgg      720

gacauccgcu uccuccacag cgaggcgcug cuggccgugg cccagaaccg cuggcuccac      780

aucuacgaca accagggcau cgagcugcac ugcauccggc gcugcgaccg ggugacccgc      840

cuggaguucc uccccuucca cuuccugcug gccaccgccu ccgagaccgg guuccucacg      900

uaccuggacg ucagcguggg caagaucgug gcggcccuga acgcccgggc cgggcgccuc      960

gacgucaugu cccagaaccc cuacaacgcc gugauccacc ugggccacag caacggcacc     1020

gugucccugu ggagcccggc gaugaaggag ccccucgcca agauccugug ccaccgcggg     1080

ggcguccggg ccguggccgu ggacuccacc gggaccuaca uggcgacgag cggccuggac     1140

caccagcuca agaucuucga ccugcggggg accuaccagc cccugagcac ccgcacccuc     1200

ccccacggcg ccggccaccu ggccuucucc cagcgggggc ugcucgucgc cggcaugggg     1260

gacgugguca acaucugggc cggccagggg aaggcgagcc cgcccucccu ggagcagccc     1320

uaccugacgc accgccucag cggcccggug cacggccugc aguucugccc cuucgaggac     1380

gugcuggggg ucggccacac cgggggcauc accuccaugc ucgugcccgg ggccggcgag     1440

cccaacuucg acggccugga gagcaacccg uaccgguccc gcaagcagcg gcaggagugg     1500

gaggugaagg cccugcucga gaaggucccc gccgagcuga ucugccugga cccccgcgcc     1560

cuggcggagg uggacgugau cagccucgag caggggaaga aggagcagau cgagcggcug     1620

ggcuacgacc cccaggccaa ggccccguuc cagcccaagc ccaagcagaa ggggcgcucc     1680

agcaccgccu cccuggucaa gcggaagcgc aaggugaugg acgaggagca ccgcgacaag     1740

gugcggcaga gccuccagca gcagcaccac aaggaggcca aggcgaagcc cacgggcgcc     1800

cgcccguccg cccuggaccg guucguccgc uga                                  1833


<210>  646
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BING-4__Homo_sapiens__CCDS4772.1

<400>  646
auggagaccg cccccaagcc cggcaaggac guccccccca agaaggacaa gcuccagacc       60

aagcgcaaga agccccgccg cuacugggag gaggagaccg uccccaccac cgccggcgcc      120

ucccccggcc ccccccgcaa caagaagaac cgcgagcucc gcccccagcg ccccaagaac      180

gccuacaucc ucaagaaguc ccgcaucucc aagaagcccc agguccccaa gaagccccgc      240

gaguggaaga accccgaguc ccagcgcggc cucuccggca cccaggaccc cuuccccggc      300

cccgcccccg uccccgucga ggucguccag aaguucugcc gcaucgacaa gucccgcaag      360

cucccccacu ccaaggccaa gacccgcucc cgccucgagg ucgccgaggc cgaggaggag      420

gagaccucca ucaaggccgc ccgcuccgag cuccuccucg ccgaggagcc cggcuuccuc      480

gagggcgagg acggcgagga caccgccaag aucugccagg ccgacaucgu cgaggccguc      540

gacaucgccu ccgccgccaa gcacuucgac cucaaccucc gccaguucgg ccccuaccgc      600

cucaacuacu cccgcaccgg ccgccaccuc gccuucggcg gccgccgcgg ccacgucgcc      660

gcccucgacu gggucaccaa gaagcucaug ugcgagauca acgucaugga ggccguccgc      720

gacauccgcu uccuccacuc cgaggcccuc cucgccgucg cccagaaccg cuggcuccac      780

aucuacgaca accagggcau cgagcuccac ugcauccgcc gcugcgaccg cgucacccgc      840

cucgaguucc uccccuucca cuuccuccuc gccaccgccu ccgagaccgg cuuccucacc      900

uaccucgacg ucuccgucgg caagaucguc gccgcccuca acgcccgcgc cggccgccuc      960

gacgucaugu cccagaaccc cuacaacgcc gucauccacc ucggccacuc caacggcacc     1020

gucucccucu ggucccccgc caugaaggag ccccucgcca agauccucug ccaccgcggc     1080

ggcguccgcg ccgucgccgu cgacuccacc ggcaccuaca uggccaccuc cggccucgac     1140

caccagcuca agaucuucga ccuccgcggc accuaccagc cccucuccac ccgcacccuc     1200

ccccacggcg ccggccaccu cgccuucucc cagcgcggcc uccucgucgc cggcaugggc     1260

gacgucguca acaucugggc cggccagggc aaggccuccc cccccucccu cgagcagccc     1320

uaccucaccc accgccucuc cggccccguc cacggccucc aguucugccc cuucgaggac     1380

guccucggcg ucggccacac cggcggcauc accuccaugc ucguccccgg cgccggcgag     1440

cccaacuucg acggccucga guccaacccc uaccgcuccc gcaagcagcg ccaggagugg     1500

gaggucaagg cccuccucga gaaggucccc gccgagcuca ucugccucga cccccgcgcc     1560

cucgccgagg ucgacgucau cucccucgag cagggcaaga aggagcagau cgagcgccuc     1620

ggcuacgacc cccaggccaa ggcccccuuc cagcccaagc ccaagcagaa gggccgcucc     1680

uccaccgccu cccucgucaa gcgcaagcgc aaggucaugg acgaggagca ccgcgacaag     1740

guccgccagu cccuccagca gcagcaccac aaggaggcca aggccaagcc caccggcgcc     1800

cgccccuccg cccucgaccg cuucguccgc uga                                  1833


<210>  647
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BING-4__Homo_sapiens__CCDS4772.1

<400>  647
auggagaccg cccccaagcc uggcaaagac gugccaccga agaaagauaa gcugcagaca       60

aaaagaaaga agcccaggcg guacugggaa gaggaaacug ucccuacgac cgcuggggca      120

agcccaggac ccccucgcaa caaaaagaau cgagagcucc guccacaaag acccaaaaac      180

gccuauaucc uuaagaaauc caggauuucu aagaagccuc agguuccgaa aaagccacgg      240

gaauggaaaa aucccgaguc acagcgcggu cugaguggca cacaggaccc uuucccaggg      300

cccgcgccug ugccaguaga ggugguccaa aaguuuugca gaauagauaa aagcaggaag      360

uugccccacu ccaaagcuaa gacucggucu cgcuuagaag uggccgaggc agaagaggag      420

gaaaccucga ucaaggccgc ucgaucagag cugcuacucg cagaggaacc gggauuccug      480

gaaggcgagg acggugagga uacagccaaa auuugucagg cugacaucgu ugaagccgug      540

gauauugcga gcgcagccaa gcauuuugac cuuaaccuga gacaguucgg gccuuacagg      600

uugaauuaua gucggaccgg acgucaccuc gcuuuuggcg gccgcagagg gcaugucgcc      660

gcacuggauu gggugacuaa aaagcugaug ugcgagauca acguaaugga agcuguuagg      720

gacauacggu uccuccacuc cgaggccuua cuggcggugg cccagaaucg auggcuucau      780

aucuacgaua accaaggaau ugaauugcac uguauccgca gaugcgacag ggucacacgg      840

cuggaguuuc uacccuucca cuuucuccug gcaaccgcuu cugagacggg uuuccuuacu      900

uaucuggaug ugagcguggg caaaauuguc gccgcuuuga augcccgcgc agggagacuc      960

gacguuaugu cccagaaccc auacaaugcc gugauccauc ugggacacuc aaacggcacc     1020

guaaguuuau ggagcccugc uaugaaggaa ccccuggcga agauacucug ucauaggggu     1080

ggggugcgug cagucgccgu ggacucuaca ggaacuuaua uggcuaccuc cggccuugau     1140

caccagcuga aaauuuuuga cuugcggggc acauaccagc cacuaucaac ccgaacgcug     1200

ccccacgggg ccggacaucu cgcauucagc caaagagguc ugcuuguugc cggcaugggg     1260

gaugugguca auaucugggc uggacagggc aaggccaguc cuccaucucu ggagcagccg     1320

uacuugacuc acaggcucuc cggucccgug caugggcugc aauuuugccc uuucgaagac     1380

guauuaggcg uuggacacac aggcgggauu accagcaugc uggugccagg agcgggugag     1440

cccaacuucg auggccuaga aucgaauccu uaucgcucuc ggaaacagag acaggagugg     1500

gaggucaagg cacuccugga aaaagugcca gcugagcuua ucuguuugga ccccagggcc     1560

cuggcagaag ucgaugugau cucccucgag caggggaaga aggagcaaau ugaacgccug     1620

ggauacgacc cgcaggccaa agcuccuuuu cagccaaagc ccaaacagaa gggccgauca     1680

aguacugcca gccuuguuaa acggaagcgu aaggugaugg augaggaaca uagagacaaa     1740

guaaggcaau cccugcagca gcagcaccac aaggaggcaa aagcuaagcc uacaggugcc     1800

cgccccucug cguuggaucg guucgucaga uga                                  1833


<210>  648
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BING-4__Homo_sapiens__CCDS4772.1

<400>  648
auggagaccg cccccaagcc cggcaaggac gugcccccca agaaggacaa gcugcagacc       60

aagagaaaga agcccagaag auacugggag gaggagaccg ugcccaccac cgccggcgcc      120

agccccggcc cccccagaaa caagaagaac agagagcuga gaccccagag acccaagaac      180

gccuacaucc ugaagaagag cagaaucagc aagaagcccc aggugcccaa gaagcccaga      240

gaguggaaga accccgagag ccagagaggc cugagcggca cccaggaccc cuuccccggc      300

cccgcccccg ugcccgugga gguggugcag aaguucugca gaaucgacaa gagcagaaag      360

cugccccaca gcaaggccaa gaccagaagc agacuggagg uggccgaggc cgaggaggag      420

gagaccagca ucaaggccgc cagaagcgag cugcugcugg ccgaggagcc cggcuuccug      480

gagggcgagg acggcgagga caccgccaag aucugccagg ccgacaucgu ggaggccgug      540

gacaucgcca gcgccgccaa gcacuucgac cugaaccuga gacaguucgg ccccuacaga      600

cugaacuaca gcagaaccgg cagacaccug gccuucggcg gcagaagagg ccacguggcc      660

gcccuggacu gggugaccaa gaagcugaug ugcgagauca acgugaugga ggccgugaga      720

gacaucagau uccugcacag cgaggcccug cuggccgugg cccagaacag auggcugcac      780

aucuacgaca accagggcau cgagcugcac ugcaucagaa gaugcgacag agugaccaga      840

cuggaguucc ugcccuucca cuuccugcug gccaccgcca gcgagaccgg cuuccugacc      900

uaccuggacg ugagcguggg caagaucgug gccgcccuga acgccagagc cggcagacug      960

gacgugauga gccagaaccc cuacaacgcc gugauccacc ugggccacag caacggcacc     1020

gugagccugu ggagccccgc caugaaggag ccccuggcca agauccugug ccacagaggc     1080

ggcgugagag ccguggccgu ggacagcacc ggcaccuaca uggccaccag cggccuggac     1140

caccagcuga agaucuucga ccugagaggc accuaccagc cccugagcac cagaacccug     1200

ccccacggcg ccggccaccu ggccuucagc cagagaggcc ugcugguggc cggcaugggc     1260

gacgugguga acaucugggc cggccagggc aaggccagcc cccccagccu ggagcagccc     1320

uaccugaccc acagacugag cggccccgug cacggccugc aguucugccc cuucgaggac     1380

gugcugggcg ugggccacac cggcggcauc accagcaugc uggugcccgg cgccggcgag     1440

cccaacuucg acggccugga gagcaacccc uacagaagca gaaagcagag acaggagugg     1500

gaggugaagg cccugcugga gaaggugccc gccgagcuga ucugccugga ccccagagcc     1560

cuggccgagg uggacgugau cagccuggag cagggcaaga aggagcagau cgagagacug     1620

ggcuacgacc cccaggccaa ggcccccuuc cagcccaagc ccaagcagaa gggcagaagc     1680

agcaccgcca gccuggugaa gagaaagaga aaggugaugg acgaggagca cagagacaag     1740

gugagacaga gccugcagca gcagcaccac aaggaggcca aggccaagcc caccggcgcc     1800

agacccagcg cccuggacag auucgugaga uga                                  1833


<210>  649
<211>  1833
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BING-4__Homo_sapiens__CCDS4772.1

<400>  649
auggagaccg cccccaagcc uggcaaagac gugccgccca agaaagauaa gcugcagaca       60

aaaagaaaga agccucggcg cuacugggaa gaggaaacgg uccccaccac agcuggggcc      120

agcccuggac ccccuagaaa caaaaagaau cgggagcucc gcccgcaaag acccaaaaac      180

gcguauaucc ugaagaaauc ccggauuucu aagaagccuc agguucccaa aaagccucgc      240

gaauggaaaa aucccgagag ccagagaggc cuuuccggga cccaggaccc guucccugga      300

cccgcuccug ugcccgugga ggucgugcaa aaguuuugcc ggaucgauaa aucucgcaag      360

cugccccaca gcaaagccaa gacaagaucc cggcucgaag uugccgaggc ugaagaggag      420

gaaaccucua uuaaggccgc ucgcagcgag cugcuucugg ccgaggaacc uggcuuccuc      480

gaaggggagg acggagagga uacagcgaaa aucugucagg ccgacauugu ggaagcuguc      540

gauaucgccu ccgcugccaa gcauuuugac cugaaccuga gacaguucgg cccguaccgg      600

cucaauuaua gccgcaccgg cagacaccug gcguuugggg gacggagagg ccauguggcc      660

gcucuugauu ggguuacgaa aaagcugaug ugcgagauca acgugaugga agccguccgc      720

gacauucggu uccuccacuc ugaggcucug cuugccgugg cccagaauag auggcugcau      780

aucuacgaua accaagggau ugaacuccac uguauccgcc ggugcgacag agugacccgc      840

cuggaguuuc ugcccuucca cuuucuccug gcuacagcgu ccgagaccgg auuccuuaca      900

uaucuggaug ucagcguugg caaaauugug gccgcucuca augcccgggc cgggagacug      960

gacgugaugu cucagaaccc uuacaaugcu gucauccauc uuggacacuc caacggcacc     1020

gugagccugu ggucucccgc caugaaggaa ccucucgcga agauucugug ucaucgcggc     1080

gggguucggg cuguggccgu cgacuccacg ggaacauaua uggccaccag cggccuggau     1140

caccagcuca aaaucuuuga ccugagaggg acauaccagc cccuuuccac ccgcacccug     1200

ccgcacggag cuggccaucu cgccuucucu caacgggggc ugcuuguggc uggaaugggc     1260

gauguuguga auaucugggc cggccagggg aaggcgagcc cucccucccu ggagcagccu     1320

uaccucacac acagacugag cggacccguc cauggccugc aauuuugccc uuucgaagac     1380

gugcucgggg ucggacacac gggcgggauu accucuaugc uggugcccgg cgccggagag     1440

ccgaacuucg auggccuuga auccaauccu uaucggagcc gcaaacagag acaggagugg     1500

gagguuaagg cucugcucga aaaagugccc gccgagcuga ucugucugga cccccgggcu     1560

cuugccgaag ucgaugugau uucucucgag caggggaaga aggagcaaau cgaaagacug     1620

ggauacgacc cucaggcgaa agccccguuu cagcccaagc cuaaacagaa gggccgcagc     1680

uccacagcuu cucugguuaa acggaagaga aaggugaugg augaggaaca ucgcgacaaa     1740

gucagacaaa gccuccagca gcagcaccac aaggaggcca aagcuaagcc caccggggcc     1800

cggccuuccg cccuggaucg cuucgugaga uga                                  1833


<210>  650
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BIRC7__Homo_sapiens__Q96CA5

<400>  650

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala 
    210                 215                 220                 


Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu 
225                 230                 235                 240 


Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu 
                245                 250                 255     


Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys 
            260                 265                 270         


Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro 
        275                 280                 285             


Val Arg Ser Arg Val Arg Thr Phe Leu Ser 
    290                 295             


<210>  651
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BIRC7__Homo_sapiens__AAG37878

<400>  651
augggaccua aagacagugc caagugccug caccguggac cacagccgag ccacugggca       60

gccggugaug gucccacgca ggagcgcugu ggaccccgcu cucugggcag cccuguccua      120

ggccuggaca ccugcagagc cugggaccac guggaugggc agauccuggg ccagcugcgg      180

ccccugacag aggaggaaga ggaggagggc gccggggcca ccuuguccag ggggccugcc      240

uuccccggca ugggcucuga ggaguugcgu cuggccuccu ucuaugacug gccgcugacu      300

gcugaggugc cacccgagcu gcuggcugcu gccggcuucu uccacacagg ccaucaggac      360

aaggugaggu gcuucuucug cuaugggggc cugcagagcu ggaagcgcgg ggacgacccc      420

uggacggagc augccaagug guuccccagc ugucaguucc ugcuccgguc aaaaggaaga      480

gacuuugucc acagugugca ggagacucac ucccagcugc ugggcucuug ggacccgugg      540

gaagaaccgg aagacgcagc cccuguggcc cccuccgucc cugccucugg guacccugag      600

cugcccacac ccaggagaga gguccagucu gaaagugccc aggagccagg aggggucagu      660

ccagccgagg cccagagggc gugguggguu cuugagcccc caggagccag ggauguggag      720

gcgcagcugc ggcggcugca ggaggagagg acgugcaagg ugugccugga ccgcgccgug      780

uccaucgucu uugugccgug cggccaccug gucugugcug agugugcccc cggccugcag      840

cugugcccca ucugcagagc ccccguccgc agccgcgugc gcaccuuccu guccuag         897


<210>  652
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BIRC7__Homo_sapiens__AAG37878

<400>  652
augggcccca aggacagcgc caagugccug caccgcgggc cgcagcccuc ccacugggcc       60

gcgggcgacg ggcccaccca ggagcggugc ggcccccgca gccucggguc cccggugcug      120

ggccuggaca cgugccgggc cugggaccac gucgacggcc agauccucgg gcagcugcgc      180

ccccugaccg aggaggagga ggaggagggc gccggggcca cccucagccg gggccccgcc      240

uuccccggga ugggcuccga ggagcugcgc cuggcgagcu ucuacgacug gccgcucacc      300

gccgaggugc cgcccgagcu gcuggccgcc gcgggcuucu uccacaccgg gcaccaggac      360

aaggugcggu gcuucuucug cuacggcggg cuccaguccu ggaagcgcgg cgacgacccc      420

uggacggagc acgccaagug guuccccagc ugccaguucc ugcugcgguc caagggccgc      480

gacuucgucc acagcgugca ggagacccac ucccagcucc uggggagcug ggaccccugg      540

gaggagcccg aggacgccgc ccccguggcc ccguccgucc ccgcgagcgg cuaccccgag      600

cugcccaccc cgcggcgcga ggugcagucc gagagcgccc aggagcccgg gggcgugucc      660

cccgccgagg cccagcgggc cugguggguc cucgagcccc cgggggcgcg cgacguggag      720

gcccagcugc ggcgccugca ggaggagcgg accugcaagg ugugccucga ccgcgccguc      780

agcaucgugu ucgugcccug cggccaccug gucugcgccg agugcgcccc cggccugcag      840

cucugcccca ucugccgggc gccggugcgc ucccgggugc gcacguuccu gagcuga         897


<210>  653
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BIRC7__Homo_sapiens__AAG37878

<400>  653
augggcccca aggacuccgc caagugccuc caccgcggcc cccagcccuc ccacugggcc       60

gccggcgacg gccccaccca ggagcgcugc ggcccccgcu cccucggcuc ccccguccuc      120

ggccucgaca ccugccgcgc cugggaccac gucgacggcc agauccucgg ccagcuccgc      180

ccccucaccg aggaggagga ggaggagggc gccggcgcca cccucucccg cggccccgcc      240

uuccccggca ugggcuccga ggagcuccgc cucgccuccu ucuacgacug gccccucacc      300

gccgaggucc cccccgagcu ccucgccgcc gccggcuucu uccacaccgg ccaccaggac      360

aagguccgcu gcuucuucug cuacggcggc cuccaguccu ggaagcgcgg cgacgacccc      420

uggaccgagc acgccaagug guuccccucc ugccaguucc uccuccgcuc caagggccgc      480

gacuucgucc acuccgucca ggagacccac ucccagcucc ucggcuccug ggaccccugg      540

gaggagcccg aggacgccgc ccccgucgcc cccuccgucc ccgccuccgg cuaccccgag      600

cuccccaccc cccgccgcga gguccagucc gaguccgccc aggagcccgg cggcgucucc      660

cccgccgagg cccagcgcgc cugguggguc cucgagcccc ccggcgcccg cgacgucgag      720

gcccagcucc gccgccucca ggaggagcgc accugcaagg ucugccucga ccgcgccguc      780

uccaucgucu ucguccccug cggccaccuc gucugcgccg agugcgcccc cggccuccag      840

cucugcccca ucugccgcgc ccccguccgc ucccgcgucc gcaccuuccu cuccuga         897


<210>  654
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BIRC7__Homo_sapiens__AAG37878

<400>  654
augggcccca aggacagcgc caaaugccug cacagagggc cucagccauc ccauugggcu       60

gcaggagaug guccgaccca agagaggugu ggcccccggu cucucggguc accugugcuu      120

ggacuggaca caugccgcgc cugggaucac gucgacggcc agaucuuggg ucaguuacga      180

ccacugacug aagaggaaga ggaagagggg gcgggagcua cgcuaagucg uggccccgcc      240

uucccuggca uggggagcga ggaacucaga cuggcauccu uuuacgauug gccacuuacc      300

gccgagguuc ccccugaacu guuggcugca gccggauucu uucauacagg ucaccaggac      360

aaggugaggu guuucuuuug cuauggcggg cuccaaucuu ggaaacgggg agaugaccca      420

uggacugagc augcuaagug guucccgucg ugucaguuuc ugcugcgcuc aaaaggcaga      480

gauuucguac acagcgugca ggagacccac agucagcucu uagguuccug ggaccccugg      540

gaggaaccug aagaugccgc gccagucgca cccucugugc cugccagcgg guacccagag      600

cugcccacac cgaggcggga aguucaaucc gagucagcuc aggagccugg aggcgugagu      660

cccgccgaag cacagcgcgc uugguggguc cuugagccac cuggcgcccg agacguggaa      720

gcgcaguuga gaaggcugca agaggaacgg accugcaagg uaugucuaga ucgugccguu      780

agcauugugu uuguccccug cgggcaucuc gugugugcag agugcgcucc aggacugcag      840

cuuuguccca uaugccgcgc cccugugaga ucuagggucc ggacuuuccu guccuga         897


<210>  655
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BIRC7__Homo_sapiens__AAG37878

<400>  655
augggcccca aggacagcgc caagugccug cacagaggcc cccagcccag ccacugggcc       60

gccggcgacg gccccaccca ggagagaugc ggccccagaa gccugggcag ccccgugcug      120

ggccuggaca ccugcagagc cugggaccac guggacggcc agauccuggg ccagcugaga      180

ccccugaccg aggaggagga ggaggagggc gccggcgcca cccugagcag aggccccgcc      240

uuccccggca ugggcagcga ggagcugaga cuggccagcu ucuacgacug gccccugacc      300

gccgaggugc cccccgagcu gcuggccgcc gccggcuucu uccacaccgg ccaccaggac      360

aaggugagau gcuucuucug cuacggcggc cugcagagcu ggaagagagg cgacgacccc      420

uggaccgagc acgccaagug guuccccagc ugccaguucc ugcugagaag caagggcaga      480

gacuucgugc acagcgugca ggagacccac agccagcugc ugggcagcug ggaccccugg      540

gaggagcccg aggacgccgc ccccguggcc cccagcgugc ccgccagcgg cuaccccgag      600

cugcccaccc ccagaagaga ggugcagagc gagagcgccc aggagcccgg cggcgugagc      660

cccgccgagg cccagagagc cuggugggug cuggagcccc ccggcgccag agacguggag      720

gcccagcuga gaagacugca ggaggagaga accugcaagg ugugccugga cagagccgug      780

agcaucgugu ucgugcccug cggccaccug gugugcgccg agugcgcccc cggccugcag      840

cugugcccca ucugcagagc ccccgugaga agcagaguga gaaccuuccu gagcuga         897


<210>  656
<211>  897
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BIRC7__Homo_sapiens__AAG37878

<400>  656
augggcccca aggacagcgc caaaugccug cacagagggc cucagccguc ccauugggcu       60

gccggagaug gccccaccca agagcggugu gggccucgcu cucucggaag ccccgugcug      120

ggccuugaca caugcagagc gugggaucac gucgacgggc agauccuggg acagcuccgg      180

ccucugacgg aagaggaaga ggaagagggc gcuggcgcca cccuuucccg cgggcccgcc      240

uucccuggaa ugggcucuga ggaacugaga cucgcuagcu uuuacgauug gccgcugaca      300

gccgagguuc ccccugaacu gcucgcugcc gcgggguucu uucauaccgg acaccaggac      360

aaggugcggu guuucuuuug cuauggcggg cugcaauccu ggaaacgcgg agaugacccc      420

uggacagagc augccaagug guucccuucu ugucaguuuc uucugagaag caaaggccgg      480

gauuucgugc acuccgucca ggagacccac agccagcucc ugggcucuug ggaccccugg      540

gaggaaccgg aagaugcugc cccuguggcu cccuccguuc cugccagcgg guaccccgag      600

cuucccacac cucgcagaga agugcaaucu gaguccgcgc aggagccggg aggcgucagc      660

cccgccgaag cucagcgggc cuggugggug cuggagccuc ccggggcucg cgacguugaa      720

gcccagcuca gacggcugca agaggaaaga accugcaagg ugugucugga ucgcgccguc      780

ucuauugugu uugugccuug cggacaucuc gucugugcug agugcgcgcc cggccugcag      840

cuuuguccga ucugccgggc cccuguuaga ucccgcgugc ggacguuccu gagcuga         897


<210>  657
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__A0A024R1V0

<400>  657

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Val Leu Thr 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
                565                 570                 575     


Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
            660                 665                 670         


Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
        675                 680                 685             


Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 
    690                 695                 700                 


Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 
705                 710                 715                 720 


Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 
                725                 730                 735     


Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 
            740                 745                 750         


Gln Ile Pro His Ser His Tyr 
        755                 


<210>  658
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__EAW60925

<400>  658
auggauuuau cugcucuucg cguugaagaa guacaaaaug ucauuaaugc uaugcagaaa       60

aucuuagagu gucccaucug ucuggaguug aucaaggaac cugucuccac aaagugugac      120

cacauauuuu gcaaauuuug caugcugaaa cuucucaacc agaagaaagg gccuucacag      180

uguccuuuau guaagaauga uauaaccaaa aggagccuac aagaaaguac gagauuuagu      240

caacuuguug aagagcuauu gaaaaucauu ugugcuuuuc agcuugacac agguuuggag      300

uaugcaaaca gcuauaauuu ugcaaaaaag gaaaauaacu cuccugaaca ucuaaaagau      360

gaaguuucua ucauccaaag uaugggcuac agaaaccgug ccaaaagacu ucuacagagu      420

gaacccgaaa auccuuccuu gcaggaaacc agucucagug uccaacucuc uaaccuugga      480

acugugagaa cucugaggac aaagcagcgg auacaaccuc aaaagacguc ugucuacauu      540

gaauugggau cugauucuuc ugaagauacc guuaauaagg caacuuauug caguguggga      600

gaucaagaau uguuacaaau caccccucaa ggaaccaggg augaaaucag uuuggauucu      660

gcaaaaaagg cugcuuguga auuuucugag acggauguaa caaauacuga acaucaucaa      720

cccaguaaua augauuugaa caccacugag aagcgugcag cugagaggca uccagaaaag      780

uaucagggug aagcagcauc ugggugugag agugaaacaa gcgucucuga agacugcuca      840

gggcuauccu cucagaguga cauuuuaacc acucagcaga gggauaccau gcaacauaac      900

cugauaaagc uccagcagga aauggcugaa cuagaagcug uguuagaaca gcaugggagc      960

cagccuucua acagcuaccc uuccaucaua agugacucuu cugcccuuga ggaccugcga     1020

aauccagaac aaagcacauc agaaaaagua uuaacuucac agaaaaguag ugaauacccu     1080

auaagccaga auccagaagg ccuuucugcu gacaaguuug aggugucugc agauaguucu     1140

accaguaaaa auaaagaacc aggaguggaa aggucauccc cuucuaaaug cccaucauua     1200

gaugauaggu gguacaugca caguugcucu gggagucuuc agaauagaaa cuacccaucu     1260

caagaggagc ucauuaaggu uguugaugug gaggagcaac agcuggaaga gucugggcca     1320

cacgauuuga cggaaacauc uuacuugcca aggcaagauc uagagggaac cccuuaccug     1380

gaaucuggaa ucagccucuu cucugaugac ccugaaucug auccuucuga agacagagcc     1440

ccagagucag cucguguugg caacauacca ucuucaaccu cugcauugaa aguuccccaa     1500

uugaaaguug cagaaucugc ccagagucca gcugcugcuc auacuacuga uacugcuggg     1560

uauaaugcaa uggaagaaag ugugagcagg gagaagccag aauugacagc uucaacagaa     1620

agggucaaca aaagaauguc caugguggug ucuggccuga ccccagaaga auuuaugcuc     1680

guguacaagu uugccagaaa acaccacauc acuuuaacua aucuaauuac ugaagagacu     1740

acucauguug uuaugaaaac agaugcugag uuugugugug aacggacacu gaaauauuuu     1800

cuaggaauug cgggaggaaa auggguaguu agcuauuucu gggugaccca gucuauuaaa     1860

gaaagaaaaa ugcugaauga gcaugauuuu gaagucagag gagauguggu caauggaaga     1920

aaccaccaag guccaaagcg agcaagagaa ucccaggaca gaaagaucuu cagggggcua     1980

gaaaucuguu gcuaugggcc cuucaccaac augcccacag aucaacugga auggauggua     2040

cagcugugug gugcuucugu ggugaaggag cuuucaucau ucacccuugg cacagguguc     2100

cacccaauug ugguugugca gccagaugcc uggacagagg acaauggcuu ccaugcaauu     2160

gggcagaugu gugaggcacc uguggugacc cgagaguggg uguuggacag uguagcacuc     2220

uaccagugcc aggagcugga caccuaccug auaccccaga ucccccacag ccacuacuga     2280


<210>  659
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__EAW60925

<400>  659
auggaccuga gcgcccuccg cguggaggag guccagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcuc aucaaggagc cgguguccac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcucaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag cggucccugc aggagagcac gcgcuucucc      240

cagcucgucg aggagcugcu gaagaucauc ugcgcguucc agcucgacac cgggcuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaacu cccccgagca ccugaaggac      360

gaggugagca ucauccaguc caugggcuac cggaaccgcg ccaagcggcu ccugcagagc      420

gagccggaga accccucccu gcaggagacc agccucuccg ugcagcugag caaccugggg      480

accguccgca cgcuccggac caagcagcgc auccagcccc agaagaccuc cguguacauc      540

gagcugggca gcgacuccag cgaggacacc gugaacaagg ccacguacug cuccgucggg      600

gaccaggagc ugcuccagau cacgccccag ggcacccggg acgagaucag ccuggacagc      660

gcgaagaagg ccgccugcga guucuccgag accgacguga ccaacaccga gcaccaccag      720

ccgagcaaca acgaccugaa caccaccgag aagcgcgccg cggagcggca ccccgagaag      780

uaccagggcg aggccgccuc cgggugcgag agcgagacgu ccgugagcga ggacugcucc      840

ggccucagcu cccagagcga cauccugacc acccagcagc gcgacaccau gcagcacaac      900

cugaucaagc uccagcagga gauggccgag cuggaggccg uccuggagca gcacgggucc      960

cagcccagca acuccuaccc cagcaucauc uccgacagcu ccgcgcucga ggaccugcgg     1020

aacccggagc agagcacguc cgagaaggug cugaccagcc agaaguccag cgaguacccc     1080

aucagccaga accccgaggg ccucuccgcc gacaaguucg aggugagcgc cgacuccagc     1140

accuccaaga acaaggagcc cggggucgag cgcagcuccc cgagcaagug ccccucccug     1200

gacgaccggu gguacaugca cagcugcucc ggcagccugc agaaccgcaa cuaccccucc     1260

caggaggagc ucaucaaggu gguggacguc gaggagcagc agcuggagga gagcggcccc     1320

cacgaccuga ccgagacguc cuaccucccg cggcaggacc uggaggggac ccccuaccug     1380

gagagcggca ucagccucuu cuccgacgac cccgagagcg accccuccga ggaccgcgcc     1440

ccggagagcg cccggguggg gaacaucccc uccagcaccu ccgcgcugaa ggugccccag     1500

cugaaggucg ccgagagcgc ccaguccccc gccgccgcgc acaccacgga caccgccggc     1560

uacaacgcca uggaggagag cgugucccgc gagaagccgg agcucaccgc cagcaccgag     1620

cgggugaaca agcgcauguc cauggucgug agcggccuga cgcccgagga guucaugcug     1680

gucuacaagu ucgcccgcaa gcaccacauc acccugacca accucaucac cgaggagacg     1740

acccacgugg ugaugaagac cgacgcggag uucgucugcg agcggacccu gaaguacuuc     1800

cuggggaucg ccggcgggaa guggguggug uccuacuucu gggucaccca gagcaucaag     1860

gagcgcaaga ugcucaacga gcacgacuuc gaggugcggg gcgacguggu caacgggcgc     1920

aaccaccagg gccccaagcg ggcccgcgag ucccaggacc ggaagaucuu ccgcggccug     1980

gagaucugcu gcuacgggcc guucacgaac augcccaccg accagcugga guggauggug     2040

cagcucugcg gcgccagcgu ggucaaggag cuguccagcu ucacccuggg gaccggcgug     2100

caccccaucg uggucgugca gcccgacgcg uggacggagg acaacggguu ccacgccauc     2160

ggccagaugu gcgaggcccc gguggucacc cgggaguggg ugcucgacag cguggcccug     2220

uaccagugcc aggagcugga caccuaccuc aucccccaga ucccccacuc ccacuacuga     2280


<210>  660
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__EAW60925

<400>  660
auggaccucu ccgcccuccg cgucgaggag guccagaacg ucaucaacgc caugcagaag       60

auccucgagu gccccaucug ccucgagcuc aucaaggagc ccgucuccac caagugcgac      120

cacaucuucu gcaaguucug caugcucaag cuccucaacc agaagaaggg ccccucccag      180

ugcccccucu gcaagaacga caucaccaag cgcucccucc aggaguccac ccgcuucucc      240

cagcucgucg aggagcuccu caagaucauc ugcgccuucc agcucgacac cggccucgag      300

uacgccaacu ccuacaacuu cgccaagaag gagaacaacu cccccgagca ccucaaggac      360

gaggucucca ucauccaguc caugggcuac cgcaaccgcg ccaagcgccu ccuccagucc      420

gagcccgaga accccucccu ccaggagacc ucccucuccg uccagcucuc caaccucggc      480

accguccgca cccuccgcac caagcagcgc auccagcccc agaagaccuc cgucuacauc      540

gagcucggcu ccgacuccuc cgaggacacc gucaacaagg ccaccuacug cuccgucggc      600

gaccaggagc uccuccagau caccccccag ggcacccgcg acgagaucuc ccucgacucc      660

gccaagaagg ccgccugcga guucuccgag accgacguca ccaacaccga gcaccaccag      720

cccuccaaca acgaccucaa caccaccgag aagcgcgccg ccgagcgcca ccccgagaag      780

uaccagggcg aggccgccuc cggcugcgag uccgagaccu ccgucuccga ggacugcucc      840

ggccucuccu cccaguccga cauccucacc acccagcagc gcgacaccau gcagcacaac      900

cucaucaagc uccagcagga gauggccgag cucgaggccg uccucgagca gcacggcucc      960

cagcccucca acuccuaccc cuccaucauc uccgacuccu ccgcccucga ggaccuccgc     1020

aaccccgagc aguccaccuc cgagaagguc cucaccuccc agaaguccuc cgaguacccc     1080

aucucccaga accccgaggg ccucuccgcc gacaaguucg aggucuccgc cgacuccucc     1140

accuccaaga acaaggagcc cggcgucgag cgcuccuccc ccuccaagug ccccucccuc     1200

gacgaccgcu gguacaugca cuccugcucc ggcucccucc agaaccgcaa cuaccccucc     1260

caggaggagc ucaucaaggu cgucgacguc gaggagcagc agcucgagga guccggcccc     1320

cacgaccuca ccgagaccuc cuaccucccc cgccaggacc ucgagggcac ccccuaccuc     1380

gaguccggca ucucccucuu cuccgacgac cccgaguccg accccuccga ggaccgcgcc     1440

cccgaguccg cccgcgucgg caacaucccc uccuccaccu ccgcccucaa ggucccccag     1500

cucaaggucg ccgaguccgc ccaguccccc gccgccgccc acaccaccga caccgccggc     1560

uacaacgcca uggaggaguc cgucucccgc gagaagcccg agcucaccgc cuccaccgag     1620

cgcgucaaca agcgcauguc cauggucguc uccggccuca cccccgagga guucaugcuc     1680

gucuacaagu ucgcccgcaa gcaccacauc acccucacca accucaucac cgaggagacc     1740

acccacgucg ucaugaagac cgacgccgag uucgucugcg agcgcacccu caaguacuuc     1800

cucggcaucg ccggcggcaa gugggucguc uccuacuucu gggucaccca guccaucaag     1860

gagcgcaaga ugcucaacga gcacgacuuc gagguccgcg gcgacgucgu caacggccgc     1920

aaccaccagg gccccaagcg cgcccgcgag ucccaggacc gcaagaucuu ccgcggccuc     1980

gagaucugcu gcuacggccc cuucaccaac augcccaccg accagcucga guggaugguc     2040

cagcucugcg gcgccuccgu cgucaaggag cucuccuccu ucacccucgg caccggcguc     2100

caccccaucg ucgucgucca gcccgacgcc uggaccgagg acaacggcuu ccacgccauc     2160

ggccagaugu gcgaggcccc cgucgucacc cgcgaguggg uccucgacuc cgucgcccuc     2220

uaccagugcc aggagcucga caccuaccuc aucccccaga ucccccacuc ccacuacuga     2280


<210>  661
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__EAW60925

<400>  661
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuugagu gccccauaug ucuggaauug aucaaagagc cuguguccac caagugcgau      120

cacauuuucu guaaauuuug cauguuaaag cugcuaaacc agaaaaaggg cccaucucag      180

uguccgcucu gcaagaauga caucacaaaa aggucacugc aggaaaguac ucgguucagc      240

caacuuguag aggagcuguu gaagauuauc ugugcauuuc agcucgauac ggggcuggaa      300

uacgccaacu ccuauaauuu cgcgaaaaag gagaacaauu cucccgaaca ucugaaagac      360

gaggugucga uaauccaguc aaugggauac cgcaaccgag cuaagcgucu cuuacagagc      420

gagccugaaa auccaagucu gcaagagacc ucccuuucug uccaguugag caaccugggu      480

acagugagaa cucuaaggac caagcagcgg auucagcccc agaaaacauc cguuuauauc      540

gaacucggcu cagauaguag cgaggacacc gugaauaagg ccacuuacug cucugucggg      600

gaucaagaac ugcuucagau uacaccucaa ggaacccgcg acgagaucuc ccuggauuca      660

gcgaaaaagg ccgcuuguga guuuagcgaa acggacguga cuaacaccga gcaccaucag      720

ccaaguaaua acgauuugaa uacaacugag aaaagagcag ccgagaggca ccccgaaaag      780

uaucagggcg aggcugccuc ugguugcgag uccgaaacca gcguaucgga ggacuguucu      840

gggcucuccu cacagaguga uauacugaca acccaacagc gggacacgau gcagcauaac      900

uuaauuaaac ugcagcaaga aauggcggag cucgaagcag uucuugagca gcacggaagc      960

cagccuucca acucuuaccc aagcaucauu ucagacaguu ccgcccugga ggauuugcgc     1020

aauccggaac agagcacuuc ugagaaggug cuaacaucac aaaagaguag cgaauauccc     1080

aucucccaga acccugaggg ccugucugcu gacaaauucg aggucucggc cgauagcucc     1140

accucaaaga auaaagaacc aggcguggag cgaaguucuc ccagcaagug cccuucccuc     1200

gacgauagau gguacaugca cucaugcagc gggucucugc agaacaggaa uuacccaucc     1260

caggaagaac uuaucaaagu ggucgacguu gaagaacaac agcuggagga aaguggaccc     1320

caugauuuga cugagacaag cuaucucccg cggcaggacc uggaagguac cccuuacuua     1380

gagucuggca uuucccuguu uucagaugac cccgaaagug auccaagcga ggaccgugca     1440

ccugagucgg cucgcguggg gaacauaccc uccucuacga gcgcccuaaa gguaccacaa     1500

cucaaggugg cggaaucagc ccagaguccc gcagcugccc acaccacaga cacugcugga     1560

uauaaugcca uggaggaauc cgucucuaga gagaaaccug aacugaccgc aagcacagag     1620

agggugaaca agcggauguc caugguugug ucaggccuua cuccagagga guucauguug     1680

gucuacaaau uugcccgaaa gcaucacauc acccugacaa aucucauuac cgaggaaacu     1740

acgcacgugg uaaugaaaac agaugcugag uucguuugug agcgcacccu gaaguauuuu     1800

cuugguaucg cagggggaaa gugggugguc agcuacuucu gggugacuca gaguauaaaa     1860

gaaagaaaga ugcugaacga gcaugacuuu gaagucaggg gcgauguggu uaauggccgg     1920

aaccaccagg ggccgaaacg cgcaagagag ucucaagaca ggaagauuuu ccguggauug     1980

gaaaucugcu guuauggucc cuucaccaau augccuacag aucagcucga guggauggug     2040

cagcugugcg gcgccuccgu agucaaagag uuaagcucgu uuacccuggg gacuggagug     2100

cauccaaucg uuguggucca gcccgacgcu uggacagaag auaacggcuu ccacgccauu     2160

ggucaaaugu gugaggcacc ugugguaacg cgggaauggg ugcuagacuc aguugcccuc     2220

uaccagugcc aggagcugga uaccuaccuu aucccacaga uuccccauuc ucacuauuga     2280


<210>  662
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__EAW60925

<400>  662
auggaccuga gcgcccugag aguggaggag gugcagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcug aucaaggagc ccgugagcac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcugaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag agaagccugc aggagagcac cagauucagc      240

cagcuggugg aggagcugcu gaagaucauc ugcgccuucc agcuggacac cggccuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaaca gccccgagca ccugaaggac      360

gaggugagca ucauccagag caugggcuac agaaacagag ccaagagacu gcugcagagc      420

gagcccgaga accccagccu gcaggagacc agccugagcg ugcagcugag caaccugggc      480

accgugagaa cccugagaac caagcagaga auccagcccc agaagaccag cguguacauc      540

gagcugggca gcgacagcag cgaggacacc gugaacaagg ccaccuacug cagcgugggc      600

gaccaggagc ugcugcagau caccccccag ggcaccagag acgagaucag ccuggacagc      660

gccaagaagg ccgccugcga guucagcgag accgacguga ccaacaccga gcaccaccag      720

cccagcaaca acgaccugaa caccaccgag aagagagccg ccgagagaca ccccgagaag      780

uaccagggcg aggccgccag cggcugcgag agcgagacca gcgugagcga ggacugcagc      840

ggccugagca gccagagcga cauccugacc acccagcaga gagacaccau gcagcacaac      900

cugaucaagc ugcagcagga gauggccgag cuggaggccg ugcuggagca gcacggcagc      960

cagcccagca acagcuaccc cagcaucauc agcgacagca gcgcccugga ggaccugaga     1020

aaccccgagc agagcaccag cgagaaggug cugaccagcc agaagagcag cgaguacccc     1080

aucagccaga accccgaggg ccugagcgcc gacaaguucg aggugagcgc cgacagcagc     1140

accagcaaga acaaggagcc cggcguggag agaagcagcc ccagcaagug ccccagccug     1200

gacgacagau gguacaugca cagcugcagc ggcagccugc agaacagaaa cuaccccagc     1260

caggaggagc ugaucaaggu gguggacgug gaggagcagc agcuggagga gagcggcccc     1320

cacgaccuga ccgagaccag cuaccugccc agacaggacc uggagggcac ccccuaccug     1380

gagagcggca ucagccuguu cagcgacgac cccgagagcg accccagcga ggacagagcc     1440

cccgagagcg ccagaguggg caacaucccc agcagcacca gcgcccugaa ggugccccag     1500

cugaaggugg ccgagagcgc ccagagcccc gccgccgccc acaccaccga caccgccggc     1560

uacaacgcca uggaggagag cgugagcaga gagaagcccg agcugaccgc cagcaccgag     1620

agagugaaca agagaaugag caugguggug agcggccuga cccccgagga guucaugcug     1680

guguacaagu ucgccagaaa gcaccacauc acccugacca accugaucac cgaggagacc     1740

acccacgugg ugaugaagac cgacgccgag uucgugugcg agagaacccu gaaguacuuc     1800

cugggcaucg ccggcggcaa guggguggug agcuacuucu gggugaccca gagcaucaag     1860

gagagaaaga ugcugaacga gcacgacuuc gaggugagag gcgacguggu gaacggcaga     1920

aaccaccagg gccccaagag agccagagag agccaggaca gaaagaucuu cagaggccug     1980

gagaucugcu gcuacggccc cuucaccaac augcccaccg accagcugga guggauggug     2040

cagcugugcg gcgccagcgu ggugaaggag cugagcagcu ucacccuggg caccggcgug     2100

caccccaucg ugguggugca gcccgacgcc uggaccgagg acaacggcuu ccacgccauc     2160

ggccagaugu gcgaggcccc cguggugacc agagaguggg ugcuggacag cguggcccug     2220

uaccagugcc aggagcugga caccuaccug aucccccaga ucccccacag ccacuacuga     2280


<210>  663
<211>  2280
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__EAW60925

<400>  663
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuggagu gccccaucug ucuugaacug auuaaagagc cuguguccac caagugcgau      120

cacaucuucu guaaauuuug caugcucaag cugcuuaacc agaaaaaggg cccgucucag      180

uguccccugu gcaagaauga cauuacaaaa cggagccucc aggaauccac gcgcuucucu      240

caacuggugg aggagcugcu caagaucauc ugugccuuuc agcuggauac cgggcuugaa      300

uacgcgaaca gcuauaauuu cgcuaaaaag gagaacaauu ccccugaaca ucugaaagac      360

gaggucucua uuauccagag caugggauac agaaaccggg ccaagcgccu ccugcagucc      420

gagcccgaaa auccuagccu ucaagagaca ucucuguccg ugcagcucag caaccugggc      480

accguuagaa cacugcggac caagcagcgc auucagcccc agaaaacauc uguguauauc      540

gaacucgggu ccgauagcuc ugaggacacc gucaauaagg ccacguacug cuccguggga      600

gaucaagaac ugcuucagau uaccccucaa ggcacaagag acgagaucag ccuggauucc      660

gcuaaaaagg ccgcuuguga guuuucugaa accgacguua caaacaccga gcaccaucag      720

ccgagcaaua acgaucucaa uacgacagaa aaacgggccg cggagcgcca ccccgaaaag      780

uaucaggggg aggccgcuuc cggaugcgag agcgaaaccu cuguguccga ggacuguagc      840

ggccugucua gccaguccga uauucuuaca acccaacaga gagacaccau gcagcauaac      900

cugaucaaac uccagcaaga aauggccgag cuggaagcug uccuggagca gcacggcucu      960

cagccuagca acuccuaccc cagcaucauu ucugacucca gcgcccucga ggaucugcgg     1020

aauccugaac agucuacauc cgagaaggug cuuacgagcc aaaaguccuc ugaauauccc     1080

aucagccaga acccggaggg gcuguccgcg gacaaauucg aggugucugc cgauagcucc     1140

accagcaaga auaaagaacc uggagucgag agaucuuccc ccagcaagug cccuucucuc     1200

gacgaucgcu gguacaugca cuccugcagc ggcucucugc agaaccggaa uuaccccagc     1260

caggaagaac uuauuaaagu uguggacgug gaggagcaac agcuggagga auccgggccc     1320

caugaucuca cagagaccag cuaucugccu cgccaggacc uggaaggaac accguaccuc     1380

gagucuggca ucucccuguu uagcgaugac cccgaauccg auccuucuga ggacagagcu     1440

cccgagagcg cccgggucgg gaacauuccu uccucuacca gcgcucuuaa ggugccccaa     1500

cugaagguug ccgaauccgc ccagucuccg gcugcggccc acacgacaga caccgcugga     1560

uauaaugcca uggaggaaag cguguccaga gagaaaccug aacucaccgc cagcacagag     1620

cgcgucaaca agcggauguc uauggugguu uccggccuga cccccgagga guucaugcug     1680

guguacaaau uugcuagaaa gcaucacauc acacuuacga aucucaucac cgaagaaaca     1740

acccacgucg ugaugaaaac agaugccgag uucgucugug agcgcacccu gaaguauuuu     1800

cugggcauug cugggggaaa gugggugguu agcuacuucu gggugacgca gucuaucaaa     1860

gaacggaaga ugcucaacga gcaugacuuu gaagucagag gcgauguggu uaaugggcgc     1920

aaccaccagg gaccuaaacg ggcgagagag ucccaagacc gcaagauuuu ccggggccug     1980

gaaaucugcu guuaugggcc cuucaccaau augccuacag aucagcuuga guggauggug     2040

cagcugugcg gagccagcgu cgugaaagag cucucuuccu uuacccuggg cacaggcgug     2100

caucccauug uugucgugca gccggacgcc uggaccgaag auaacggguu ccacgcuauc     2160

ggacaaaugu gugaggcccc uguggucacg agagaauggg ugcuggacag cguugcucuu     2220

uaccagugcc aggagcucga uacauaccug aucccccaga uuccccauuc ccacuauuga     2280


<210>  664
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__A0A024R1V7

<400>  664

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Ala Ala Cys Glu Phe Ser Glu Thr Asp Val 
            180                 185                 190         


Thr Asn Thr Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr 
        195                 200                 205             


Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Glu Ala 
    210                 215                 220                 


Ala Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys Ser Gly 
225                 230                 235                 240 


Leu Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp Thr Met 
                245                 250                 255     


Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu Glu Ala 
            260                 265                 270         


Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile 
        275                 280                 285             


Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser 
    290                 295                 300                 


Thr Ser Glu Lys Ala Val Leu Thr Ser Gln Lys Ser Ser Glu Tyr Pro 
305                 310                 315                 320 


Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu Val Ser 
                325                 330                 335     


Ala Asp Ser Ser Thr Ser Lys Asn Lys Glu Pro Gly Val Glu Arg Ser 
            340                 345                 350         


Ser Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met His Ser 
        355                 360                 365             


Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu 
    370                 375                 380                 


Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro 
385                 390                 395                 400 


His Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly 
                405                 410                 415     


Thr Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu 
            420                 425                 430         


Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val Gly Asn 
        435                 440                 445             


Ile Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys Val Ala 
    450                 455                 460                 


Glu Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr Ala Gly 
465                 470                 475                 480 


Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu Leu Thr 
                485                 490                 495     


Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val Val Ser Gly 
            500                 505                 510         


Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg Lys His 
        515                 520                 525             


His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr His Val Val 
    530                 535                 540                 


Met Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys Tyr Phe 
545                 550                 555                 560 


Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp Val Thr 
                565                 570                 575     


Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val 
            580                 585                 590         


Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala 
        595                 600                 605             


Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys 
    610                 615                 620                 


Tyr Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val 
625                 630                 635                 640 


Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu 
                645                 650                 655     


Gly Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr 
            660                 665                 670         


Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val 
        675                 680                 685             


Val Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln 
    690                 695                 700                 


Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr 
705                 710                 715                 


<210>  665
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__EAW60922

<400>  665
auggauuuau cugcucuucg cguugaagaa guacaaaaug ucauuaaugc uaugcagaaa       60

aucuuagagu gucccaucug ucuggaguug aucaaggaac cugucuccac aaagugugac      120

cacauauuuu gcaaauuuug caugcugaaa cuucucaacc agaagaaagg gccuucacag      180

uguccuuuau guaagaauga uauaaccaaa aggagccuac aagaaaguac gagauuuagu      240

caacuuguug aagagcuauu gaaaaucauu ugugcuuuuc agcuugacac agguuuggag      300

uaugcaaaca gcuauaauuu ugcaaaaaag gaaaauaacu cuccugaaca ucuaaaagau      360

gaaguuucua ucauccaaag uaugggcuac agaaaccgug ccaaaagacu ucuacagagu      420

gaacccgaaa auccuuccuu gcaggaaacc agucucagug uccaacucuc uaaccuugga      480

acugugagaa cucugaggac aaagcagcgg auacaaccuc aaaagacguc ugucuacauu      540

gaauuggcug cuugugaauu uucugagacg gauguaacaa auacugaaca ucaucaaccc      600

aguaauaaug auuugaacac cacugagaag cgugcagcug agaggcaucc agaaaaguau      660

cagggugaag cagcaucugg gugugagagu gaaacaagcg ucucugaaga cugcucaggg      720

cuauccucuc agagugacau uuuaaccacu cagcagaggg auaccaugca acauaaccug      780

auaaagcucc agcaggaaau ggcugaacua gaagcugugu uagaacagca ugggagccag      840

ccuucuaaca gcuacccuuc caucauaagu gacucuucug cccuugagga ccugcgaaau      900

ccagaacaaa gcacaucaga aaaagcagua uuaacuucac agaaaaguag ugaauacccu      960

auaagccaga auccagaagg ccuuucugcu gacaaguuug aggugucugc agauaguucu     1020

accaguaaaa auaaagaacc aggaguggaa aggucauccc cuucuaaaug cccaucauua     1080

gaugauaggu gguacaugca caguugcucu gggagucuuc agaauagaaa cuacccaucu     1140

caagaggagc ucauuaaggu uguugaugug gaggagcaac agcuggaaga gucugggcca     1200

cacgauuuga cggaaacauc uuacuugcca aggcaagauc uagagggaac cccuuaccug     1260

gaaucuggaa ucagccucuu cucugaugac ccugaaucug auccuucuga agacagagcc     1320

ccagagucag cucguguugg caacauacca ucuucaaccu cugcauugaa aguuccccaa     1380

uugaaaguug cagaaucugc ccagagucca gcugcugcuc auacuacuga uacugcuggg     1440

uauaaugcaa uggaagaaag ugugagcagg gagaagccag aauugacagc uucaacagaa     1500

agggucaaca aaagaauguc caugguggug ucuggccuga ccccagaaga auuuaugcuc     1560

guguacaagu uugccagaaa acaccacauc acuuuaacua aucuaauuac ugaagagacu     1620

acucauguug uuaugaaaac agaugcugag uuugugugug aacggacacu gaaauauuuu     1680

cuaggaauug cgggaggaaa auggguaguu agcuauuucu gggugaccca gucuauuaaa     1740

gaaagaaaaa ugcugaauga gcaugauuuu gaagucagag gagauguggu caauggaaga     1800

aaccaccaag guccaaagcg agcaagagaa ucccaggaca gaaagaucuu cagggggcua     1860

gaaaucuguu gcuaugggcc cuucaccaac augcccacag aucaacugga auggauggua     1920

cagcugugug gugcuucugu ggugaaggag cuuucaucau ucacccuugg cacagguguc     1980

cacccaauug ugguugugca gccagaugcc uggacagagg acaauggcuu ccaugcaauu     2040

gggcagaugu gugaggcacc uguggugacc cgagaguggg uguuggacag uguagcacuc     2100

uaccagugcc aggagcugga caccuaccug auaccccaga ucccccacag ccacuacuga     2160


<210>  666
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__EAW60922

<400>  666
auggaccuga gcgcccuccg cguggaggag guccagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcuc aucaaggagc cgguguccac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcucaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag cggucccugc aggagagcac gcgcuucucc      240

cagcucgucg aggagcugcu gaagaucauc ugcgcguucc agcucgacac cgggcuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaacu cccccgagca ccugaaggac      360

gaggugagca ucauccaguc caugggcuac cggaaccgcg ccaagcggcu ccugcagagc      420

gagccggaga accccucccu gcaggagacc agccucuccg ugcagcugag caaccugggg      480

accguccgca cgcuccggac caagcagcgc auccagcccc agaagaccuc cguguacauc      540

gagcuggccg cgugcgaguu cagcgagacc gacgugacga acaccgagca ccaccagccc      600

uccaacaacg accugaacac caccgagaag cgggccgccg agcgccaccc ggagaaguac      660

cagggcgagg ccgcgagcgg gugcgagucc gagacgagcg ucagcgagga cugcuccggc      720

cucagcuccc agagcgacau ccugaccacc cagcagcggg acaccaugca gcacaaccug      780

aucaagcucc agcaggagau ggccgagcug gaggccgugc uggagcagca cggcucccag      840

cccagcaacu ccuaccccag caucaucucc gacagcuccg cccucgagga ccugcgcaac      900

cccgagcaga gcacguccga gaaggccgug cugaccagcc agaaguccag cgaguacccg      960

aucucccaga accccgaggg gcucagcgcg gacaaguucg aggucuccgc cgacagcagc     1020

accuccaaga acaaggagcc cggcguggag cggagcuccc ccagcaagug cccgucccug     1080

gacgaccgcu gguacaugca cagcugcucc gggagccugc agaaccggaa cuaccccucc     1140

caggaggagc ucaucaaggu ggucgacgug gaggagcagc agcuggagga gagcggcccc     1200

cacgaccuga ccgagacguc cuaccucccc cgccaggacc uggaggggac cccguaccug     1260

gagagcggca ucucccucuu cagcgacgac cccgaguccg accccagcga ggaccgggcc     1320

cccgaguccg cccgcguggg caacaucccg agcagcaccu ccgcccugaa ggucccccag     1380

cugaaggugg cggagagcgc ccaguccccc gccgccgccc acaccacgga caccgcgggg     1440

uacaacgcca uggaggagag cgugucccgg gagaagcccg agcucaccgc cagcaccgag     1500

cgcgucaaca agcggauguc caugguggug agcggccuga cgccggagga guucaugcug     1560

gucuacaagu ucgcccgcaa gcaccacauc acccucacca accugaucac cgaggagacg     1620

acccacgugg ucaugaagac cgacgccgag uucgugugcg agcgcacccu gaaguacuuc     1680

cuggggaucg cgggcggcaa gugggugguc uccuacuucu gggugacgca gagcaucaag     1740

gagcggaaga ugcucaacga gcacgacuuc gaggugcgcg gggacgucgu gaacggccgg     1800

aaccaccagg ggcccaagcg cgcccgggag ucccaggacc gcaagaucuu ccggggccug     1860

gagaucugcu gcuacgggcc cuucaccaac augccgaccg accagcugga guggauggug     1920

cagcucugcg gcgccagcgu cgugaaggag cuguccagcu ucacccuggg caccggggug     1980

caccccaucg ucguggugca gcccgacgcc uggacggagg acaacggcuu ccacgcgauc     2040

gggcagaugu gcgaggcccc cgucgugacc cgcgaguggg ugcucgacuc cgucgcccug     2100

uaccagugcc aggagcugga caccuaccuc aucccgcaga ucccccacag ccacuacuga     2160


<210>  667
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__EAW60922

<400>  667
auggaccucu ccgcccuccg cgucgaggag guccagaacg ucaucaacgc caugcagaag       60

auccucgagu gccccaucug ccucgagcuc aucaaggagc ccgucuccac caagugcgac      120

cacaucuucu gcaaguucug caugcucaag cuccucaacc agaagaaggg ccccucccag      180

ugcccccucu gcaagaacga caucaccaag cgcucccucc aggaguccac ccgcuucucc      240

cagcucgucg aggagcuccu caagaucauc ugcgccuucc agcucgacac cggccucgag      300

uacgccaacu ccuacaacuu cgccaagaag gagaacaacu cccccgagca ccucaaggac      360

gaggucucca ucauccaguc caugggcuac cgcaaccgcg ccaagcgccu ccuccagucc      420

gagcccgaga accccucccu ccaggagacc ucccucuccg uccagcucuc caaccucggc      480

accguccgca cccuccgcac caagcagcgc auccagcccc agaagaccuc cgucuacauc      540

gagcucgccg ccugcgaguu cuccgagacc gacgucacca acaccgagca ccaccagccc      600

uccaacaacg accucaacac caccgagaag cgcgccgccg agcgccaccc cgagaaguac      660

cagggcgagg ccgccuccgg cugcgagucc gagaccuccg ucuccgagga cugcuccggc      720

cucuccuccc aguccgacau ccucaccacc cagcagcgcg acaccaugca gcacaaccuc      780

aucaagcucc agcaggagau ggccgagcuc gaggccgucc ucgagcagca cggcucccag      840

cccuccaacu ccuaccccuc caucaucucc gacuccuccg cccucgagga ccuccgcaac      900

cccgagcagu ccaccuccga gaaggccguc cucaccuccc agaaguccuc cgaguacccc      960

aucucccaga accccgaggg ccucuccgcc gacaaguucg aggucuccgc cgacuccucc     1020

accuccaaga acaaggagcc cggcgucgag cgcuccuccc ccuccaagug ccccucccuc     1080

gacgaccgcu gguacaugca cuccugcucc ggcucccucc agaaccgcaa cuaccccucc     1140

caggaggagc ucaucaaggu cgucgacguc gaggagcagc agcucgagga guccggcccc     1200

cacgaccuca ccgagaccuc cuaccucccc cgccaggacc ucgagggcac ccccuaccuc     1260

gaguccggca ucucccucuu cuccgacgac cccgaguccg accccuccga ggaccgcgcc     1320

cccgaguccg cccgcgucgg caacaucccc uccuccaccu ccgcccucaa ggucccccag     1380

cucaaggucg ccgaguccgc ccaguccccc gccgccgccc acaccaccga caccgccggc     1440

uacaacgcca uggaggaguc cgucucccgc gagaagcccg agcucaccgc cuccaccgag     1500

cgcgucaaca agcgcauguc cauggucguc uccggccuca cccccgagga guucaugcuc     1560

gucuacaagu ucgcccgcaa gcaccacauc acccucacca accucaucac cgaggagacc     1620

acccacgucg ucaugaagac cgacgccgag uucgucugcg agcgcacccu caaguacuuc     1680

cucggcaucg ccggcggcaa gugggucguc uccuacuucu gggucaccca guccaucaag     1740

gagcgcaaga ugcucaacga gcacgacuuc gagguccgcg gcgacgucgu caacggccgc     1800

aaccaccagg gccccaagcg cgcccgcgag ucccaggacc gcaagaucuu ccgcggccuc     1860

gagaucugcu gcuacggccc cuucaccaac augcccaccg accagcucga guggaugguc     1920

cagcucugcg gcgccuccgu cgucaaggag cucuccuccu ucacccucgg caccggcguc     1980

caccccaucg ucgucgucca gcccgacgcc uggaccgagg acaacggcuu ccacgccauc     2040

ggccagaugu gcgaggcccc cgucgucacc cgcgaguggg uccucgacuc cgucgcccuc     2100

uaccagugcc aggagcucga caccuaccuc aucccccaga ucccccacuc ccacuacuga     2160


<210>  668
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__EAW60922

<400>  668
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuugagu gccccauaug ucuggaauug aucaaagagc cuguguccac caagugcgau      120

cacauuuucu guaaauuuug cauguuaaag cugcuaaacc agaaaaaggg cccaucucag      180

uguccgcucu gcaagaauga caucacaaaa aggucacugc aggaaaguac ucgguucagc      240

caacuuguag aggagcuguu gaagauuauc ugugcauuuc agcucgauac ggggcuggaa      300

uacgccaacu ccuauaauuu cgcgaaaaag gagaacaauu cucccgaaca ucugaaagac      360

gaggugucga uaauccaguc aaugggauac cgcaaccgag cuaagcgucu cuuacagagc      420

gagccugaaa auccaagucu gcaagagacc ucccuuucug uccaguugag caaccugggu      480

acagugagaa cucuaaggac caagcagcgg auucagcccc agaaaacauc cguuuauauc      540

gaacucgccg caugcgaguu uucagaaacc gaugugacua auacagagca ccaucaaccu      600

aguaacaaug accugaacac cacggagaag cgcgccgcug aaagacaccc agagaaauac      660

cagggcgaag cagccagcgg gugugagucu gaaacuuccg ucucagagga uugcagcgga      720

cuuaguucuc aauccgacau ucugaccaca cagcagaggg auacuaugca gcauaauuug      780

aucaagcucc aacaggagau ggcugaacug gaggccgugu uagaacagca cggcagccag      840

cccucgaacu cuuauccuuc cauaauuuca gacaguagcg cgcuggagga ucuccggaac      900

ccagaacaau ccaccucuga gaaagcagua cuuacaagcc agaagucaag ugaguacccg      960

aucucccaga aucccgaagg ucugagcgcc gacaaauucg agguuucugc ugauucaagu     1020

accagcaaga acaaggaacc ugggguggag cgcuccucuc caucgaaaug ucccagcuug     1080

gacgaccgau gguauaugca cuccugcuca ggaagucuac agaauagaaa cuacccuucu     1140

caagaggaac ugauuaaggu cguggaugug gaggaacagc agcucgagga aagcggccca     1200

caugaccuga cggagacuuc cuaccuuccc aggcaggauc uggagggcac accguauuug     1260

gaaucaggga ucagccucuu uucugacgau ccugaguccg accccaguga agaucgggcc     1320

ccagagagcg cacgugucgg aaauaucccu ucuuccaccu cagcucugaa aguuccccaa     1380

uuaaaggugg ccgaaagugc gcagagccca gccgcagcuc acacuacaga caccgccggu     1440

uacaacgcua uggaggaguc gguaucccgc gaaaaacccg agcugacggc cucuaccgaa     1500

agagugaaua agaggaugag cauggucgug ucaggccuaa caccugagga guucaugcuc     1560

guuuauaagu uugcacggaa acaucacauu acucugacca accuuauaac agaagagacu     1620

acccacgugg ucaugaagac agaugccgag uucgugugcg aacgaaccuu gaaauacuuu     1680

cuggggaucg cuggaggcaa guggguaguu aguuauuucu gggugacuca guccauuaaa     1740

gaacgcaaga ugcucaauga gcaugacuuu gaggucagag gugauguggu caacgggagg     1800

aaucaccaag gaccaaagcg ggcgcgcgaa ucucaggaca gaaaaaucuu caggggccug     1860

gagauauguu gcuacggccc guucacgaac augcccacag accagcuuga auggauggug     1920

cagcugugug gggcaagcgu ugugaaggag uuguccucau uuacccucgg aacuggugua     1980

cauccuauug ucgugguuca accagaugcc uggaccgaag acaauggcuu ccacgcuauc     2040

gggcagaugu gcgaggcccc cguggucaca cgugaguggg ugcuggauag cguagcauua     2100

uaucaguguc aggaacugga caccuaccua aucccucaaa uuccacauag ucacuacuga     2160


<210>  669
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__EAW60922

<400>  669
auggaccuga gcgcccugag aguggaggag gugcagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcug aucaaggagc ccgugagcac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcugaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag agaagccugc aggagagcac cagauucagc      240

cagcuggugg aggagcugcu gaagaucauc ugcgccuucc agcuggacac cggccuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaaca gccccgagca ccugaaggac      360

gaggugagca ucauccagag caugggcuac agaaacagag ccaagagacu gcugcagagc      420

gagcccgaga accccagccu gcaggagacc agccugagcg ugcagcugag caaccugggc      480

accgugagaa cccugagaac caagcagaga auccagcccc agaagaccag cguguacauc      540

gagcuggccg ccugcgaguu cagcgagacc gacgugacca acaccgagca ccaccagccc      600

agcaacaacg accugaacac caccgagaag agagccgccg agagacaccc cgagaaguac      660

cagggcgagg ccgccagcgg cugcgagagc gagaccagcg ugagcgagga cugcagcggc      720

cugagcagcc agagcgacau ccugaccacc cagcagagag acaccaugca gcacaaccug      780

aucaagcugc agcaggagau ggccgagcug gaggccgugc uggagcagca cggcagccag      840

cccagcaaca gcuaccccag caucaucagc gacagcagcg cccuggagga ccugagaaac      900

cccgagcaga gcaccagcga gaaggccgug cugaccagcc agaagagcag cgaguacccc      960

aucagccaga accccgaggg ccugagcgcc gacaaguucg aggugagcgc cgacagcagc     1020

accagcaaga acaaggagcc cggcguggag agaagcagcc ccagcaagug ccccagccug     1080

gacgacagau gguacaugca cagcugcagc ggcagccugc agaacagaaa cuaccccagc     1140

caggaggagc ugaucaaggu gguggacgug gaggagcagc agcuggagga gagcggcccc     1200

cacgaccuga ccgagaccag cuaccugccc agacaggacc uggagggcac ccccuaccug     1260

gagagcggca ucagccuguu cagcgacgac cccgagagcg accccagcga ggacagagcc     1320

cccgagagcg ccagaguggg caacaucccc agcagcacca gcgcccugaa ggugccccag     1380

cugaaggugg ccgagagcgc ccagagcccc gccgccgccc acaccaccga caccgccggc     1440

uacaacgcca uggaggagag cgugagcaga gagaagcccg agcugaccgc cagcaccgag     1500

agagugaaca agagaaugag caugguggug agcggccuga cccccgagga guucaugcug     1560

guguacaagu ucgccagaaa gcaccacauc acccugacca accugaucac cgaggagacc     1620

acccacgugg ugaugaagac cgacgccgag uucgugugcg agagaacccu gaaguacuuc     1680

cugggcaucg ccggcggcaa guggguggug agcuacuucu gggugaccca gagcaucaag     1740

gagagaaaga ugcugaacga gcacgacuuc gaggugagag gcgacguggu gaacggcaga     1800

aaccaccagg gccccaagag agccagagag agccaggaca gaaagaucuu cagaggccug     1860

gagaucugcu gcuacggccc cuucaccaac augcccaccg accagcugga guggauggug     1920

cagcugugcg gcgccagcgu ggugaaggag cugagcagcu ucacccuggg caccggcgug     1980

caccccaucg ugguggugca gcccgacgcc uggaccgagg acaacggcuu ccacgccauc     2040

ggccagaugu gcgaggcccc cguggugacc agagaguggg ugcuggacag cguggcccug     2100

uaccagugcc aggagcugga caccuaccug aucccccaga ucccccacag ccacuacuga     2160


<210>  670
<211>  2160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__EAW60922

<400>  670
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuggagu gccccaucug ucuugaacug auuaaagagc cuguguccac caagugcgau      120

cacaucuucu guaaauuuug caugcucaag cugcuuaacc agaaaaaggg cccgucucag      180

uguccccugu gcaagaauga cauuacaaaa cggagccucc aggaauccac gcgcuucucu      240

caacuggugg aggagcugcu caagaucauc ugugccuuuc agcuggauac cgggcuugaa      300

uacgcgaaca gcuauaauuu cgcuaaaaag gagaacaauu ccccugaaca ucugaaagac      360

gaggucucua uuauccagag caugggauac agaaaccggg ccaagcgccu ccugcagucc      420

gagcccgaaa auccuagccu ucaagagaca ucucuguccg ugcagcucag caaccugggc      480

accguuagaa cacugcggac caagcagcgc auucagcccc agaaaacauc uguguauauc      540

gaacucgccg cuugcgaguu uuccgaaacc gaugucacga auaccgagca ccaucaaccu      600

agcaacaaug accugaacac aaccgagaag agagccgcug aacggcaccc ggagaaauac      660

cagggggaag ccgcgucugg augugagucc gaaacaagcg uguccgagga uugcucuggc      720

cuuagcuccc aaagcgacau ucugaccacg cagcagcgcg auacaaugca gcauaaucuc      780

aucaagcugc aacaggagau ggccgaacuu gaggcuguuc uggaacagca cgggucucag      840

cccuccaaca gcuauccuuc uauuaucagc gacuccucug cccucgagga ucugagaaac      900

cccgaacaaa gcaccuccga gaaagcugug cugacaagcc agaagucuuc cgaguacccu      960

aucagccaga aucccgaagg acucucugcc gacaaauucg aggucuccgc ggauagcucc     1020

accucuaaga acaaggaacc gggcguggag cggagcuccc cuucuaaaug ucccagccug     1080

gacgaccgcu gguauaugca cuccugcagc ggcucucuuc agaauagaaa cuacccuucc     1140

caagaggaac ugauuaaggu ggucgauguu gaggaacagc agcucgagga aagcgggccc     1200

caugaccuga ccgagacauc uuaccuuccc cggcaggauc uggagggaac gccuuaucuc     1260

gaauccggca ucagccuguu uucugacgau ccggagagcg accccuccga agaucgcgcc     1320

ccugagagcg cuagaguggg gaauauuccc ucuuccacca gcgcccugaa agugccucaa     1380

cucaaggucg cugaauccgc ccagucuccc gccgcugcgc acacaaccga cacagccgga     1440

uacaacgcua uggaggagag cgugucccgg gaaaaaccgg agcugaccgc cucuacggaa     1500

agaguuaaua agcgcaugag cauggugguc uccggccuua caccugagga guucaugcug     1560

guguauaagu uugcccggaa acaucacauc acccucacca accugauuac agaagagacc     1620

acacacguug ugaugaagac ggaugcugag uucgucugcg aaagaacccu gaaauacuuu     1680

cuugggaucg ccggaggcaa gugggugguc ucuuauuucu gggugacaca gagcaucaaa     1740

gaacgcaaga ugcucaauga gcaugacuuu gagguucggg gcgauguggu caacgggaga     1800

aaucaccaag gacccaagcg cgcgcgggaa ucccaggaca gaaaaauuuu ccgcggccug     1860

gagaucuguu gcuacgggcc uuucaccaac augcccacag accagcugga auggauggug     1920

cagcucugug gagcuagcgu ugugaaggag cugucuuccu uuacccuugg cacggggguc     1980

cauccuauug uggugguuca acccgaugcc uggaccgaag acaauggauu ccacgccauc     2040

ggccagaugu gcgaggcucc ggucgugaca cgggaguggg ugcuggauag cgucgcccuc     2100

uaucaguguc aggaacugga caccuaccug auuccucaaa ucccccauuc ucacuacuga     2160


<210>  671
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__A0A024R1Z8

<400>  671

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Gly 
    210                 215                 220                 


Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys 
225                 230                 235                 240 


Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp 
                245                 250                 255     


Thr Met Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu 
            260                 265                 270         


Glu Ala Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro 
        275                 280                 285             


Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu 
    290                 295                 300                 


Gln Ser Thr Ser Glu Lys Ala Val Leu Thr Ser Gln Lys Ser Ser Glu 
305                 310                 315                 320 


Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu 
                325                 330                 335     


Val Ser Ala Asp Ser Ser Thr Ser Lys Asn Lys Glu Pro Gly Val Glu 
            340                 345                 350         


Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met 
        355                 360                 365             


His Ser Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu 
    370                 375                 380                 


Glu Leu Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser 
385                 390                 395                 400 


Gly Pro His Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu 
                405                 410                 415     


Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp 
            420                 425                 430         


Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val 
        435                 440                 445             


Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys 
    450                 455                 460                 


Val Ala Glu Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr 
465                 470                 475                 480 


Ala Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu 
                485                 490                 495     


Leu Thr Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val Val 
            500                 505                 510         


Ser Gly Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg 
        515                 520                 525             


Lys His His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr His 
    530                 535                 540                 


Val Val Met Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys 
545                 550                 555                 560 


Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp 
                565                 570                 575     


Val Thr Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe 
            580                 585                 590         


Glu Val Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys 
        595                 600                 605             


Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile 
    610                 615                 620                 


Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp 
625                 630                 635                 640 


Met Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe 
                645                 650                 655     


Thr Leu Gly Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala 
            660                 665                 670         


Trp Thr Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala 
        675                 680                 685             


Pro Val Val Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln 
    690                 695                 700                 


Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His 
705                 710                 715                 720 


Tyr 
    


<210>  672
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__EAW60923

<400>  672
auggauuuau cugcucuucg cguugaagaa guacaaaaug ucauuaaugc uaugcagaaa       60

aucuuagagu gucccaucug ucuggaguug aucaaggaac cugucuccac aaagugugac      120

cacauauuuu gcaaauuuug caugcugaaa cuucucaacc agaagaaagg gccuucacag      180

uguccuuuau guaagaauga uauaaccaaa aggagccuac aagaaaguac gagauuuagu      240

caacuuguug aagagcuauu gaaaaucauu ugugcuuuuc agcuugacac agguuuggag      300

uaugcaaaca gcuauaauuu ugcaaaaaag gaaaauaacu cuccugaaca ucuaaaagau      360

gaaguuucua ucauccaaag uaugggcuac agaaaccgug ccaaaagacu ucuacagagu      420

gaacccgaaa auccuuccuu gcaggaaacc agucucagug uccaacucuc uaaccuugga      480

acugugagaa cucugaggac aaagcagcgg auacaaccuc aaaagacguc ugucuacauu      540

gaauugggau cugauucuuc ugaagauacc guuaauaagg caacuuauug caguguggga      600

gaucaagaau uguuacaaau caccccucaa ggaaccaggg augaaaucag uuuggauucu      660

gcaaaaaagg gugaagcagc aucugggugu gagagugaaa caagcgucuc ugaagacugc      720

ucagggcuau ccucucagag ugacauuuua accacucagc agagggauac caugcaacau      780

aaccugauaa agcuccagca ggaaauggcu gaacuagaag cuguguuaga acagcauggg      840

agccagccuu cuaacagcua cccuuccauc auaagugacu cuucugcccu ugaggaccug      900

cgaaauccag aacaaagcac aucagaaaaa gcaguauuaa cuucacagaa aaguagugaa      960

uacccuauaa gccagaaucc agaaggccuu ucugcugaca aguuugaggu gucugcagau     1020

aguucuacca guaaaaauaa agaaccagga guggaaaggu cauccccuuc uaaaugccca     1080

ucauuagaug auagguggua caugcacagu ugcucuggga gucuucagaa uagaaacuac     1140

ccaucucaag aggagcucau uaagguuguu gauguggagg agcaacagcu ggaagagucu     1200

gggccacacg auuugacgga aacaucuuac uugccaaggc aagaucuaga gggaaccccu     1260

uaccuggaau cuggaaucag ccucuucucu gaugacccug aaucugaucc uucugaagac     1320

agagccccag agucagcucg uguuggcaac auaccaucuu caaccucugc auugaaaguu     1380

ccccaauuga aaguugcaga aucugcccag aguccagcug cugcucauac uacugauacu     1440

gcuggguaua augcaaugga agaaagugug agcagggaga agccagaauu gacagcuuca     1500

acagaaaggg ucaacaaaag aauguccaug guggugucug gccugacccc agaagaauuu     1560

augcucgugu acaaguuugc cagaaaacac cacaucacuu uaacuaaucu aauuacugaa     1620

gagacuacuc auguuguuau gaaaacagau gcugaguuug ugugugaacg gacacugaaa     1680

uauuuucuag gaauugcggg aggaaaaugg guaguuagcu auuucugggu gacccagucu     1740

auuaaagaaa gaaaaaugcu gaaugagcau gauuuugaag ucagaggaga uguggucaau     1800

ggaagaaacc accaaggucc aaagcgagca agagaauccc aggacagaaa gaucuucagg     1860

gggcuagaaa ucuguugcua ugggcccuuc accaacaugc ccacagauca acuggaaugg     1920

augguacagc uguguggugc uucuguggug aaggagcuuu caucauucac ccuuggcaca     1980

gguguccacc caauuguggu ugugcagcca gaugccugga cagaggacaa uggcuuccau     2040

gcaauugggc agauguguga ggcaccugug gugacccgag aguggguguu ggacagugua     2100

gcacucuacc agugccagga gcuggacacc uaccugauac cccagauccc ccacagccac     2160

uacuga                                                                2166


<210>  673
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__EAW60923

<400>  673
auggaccuga gcgcccuccg cguggaggag guccagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcuc aucaaggagc cgguguccac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcucaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag cggucccugc aggagagcac gcgcuucucc      240

cagcucgucg aggagcugcu gaagaucauc ugcgcguucc agcucgacac cgggcuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaacu cccccgagca ccugaaggac      360

gaggugagca ucauccaguc caugggcuac cggaaccgcg ccaagcggcu ccugcagagc      420

gagccggaga accccucccu gcaggagacc agccucuccg ugcagcugag caaccugggg      480

accguccgca cgcuccggac caagcagcgc auccagcccc agaagaccuc cguguacauc      540

gagcugggca gcgacuccag cgaggacacc gugaacaagg ccacguacug cuccgucggg      600

gaccaggagc ugcuccagau cacgccccag ggcacccggg acgagaucag ccuggacagc      660

gcgaagaagg gcgaggccgc cuccgggugc gagagcgaga ccuccgugag cgaggacugc      720

uccggccuga gcucccagag cgacauccuc accacccagc agcgcgacac caugcagcac      780

aaccugauca agcugcagca ggagauggcc gagcucgagg cggugcugga gcagcacggg      840

ucccagccga gcaacuccua ccccagcauc aucuccgaca gcuccgcccu ggaggaccuc      900

cggaaccccg agcagagcac cuccgagaag gccguccuga cgagccagaa guccagcgag      960

uaccccauca gccagaaccc ggagggccug uccgccgaca aguucgaggu gagcgccgac     1020

uccagcaccu ccaagaacaa ggagcccggg guggagcgca gcucccccag caagugcccc     1080

ucccucgacg accgguggua caugcacagc ugcuccggca gccugcagaa ccgcaacuac     1140

ccgucccagg aggagcugau caaggucgug gacguggagg agcagcagcu cgaggagagc     1200

ggcccccacg accugaccga gaccuccuac cugccccggc aggaccucga ggggacgccc     1260

uaccuggaga gcggcaucuc ccuguucagc gacgacccgg agagcgaccc cuccgaggac     1320

cgcgcgcccg agagcgcccg ggucgggaac auccccucca gcaccuccgc ccucaaggug     1380

ccgcagcuga agguggccga gagcgcccag ucccccgcgg ccgcccacac caccgacacg     1440

gccggcuaca acgccaugga ggagagcguc ucccgcgaga agcccgagcu gaccgcgagc     1500

accgagcggg ugaacaagcg cauguccaug guggucagcg gccucacccc cgaggaguuc     1560

augcuggugu acaaguucgc ccggaagcac cacaucacgc ugaccaaccu gaucaccgag     1620

gagaccacgc acgucgugau gaagaccgac gccgaguucg ugugcgagcg cacccucaag     1680

uacuuccugg ggaucgccgg cgggaagugg gucguguccu acuucugggu gacccagagc     1740

aucaaggagc gcaagaugcu gaacgagcac gacuucgagg uccggggcga cguggugaac     1800

gggcgcaacc accagggccc gaagcgggcc cgcgaguccc aggaccggaa gaucuuccgc     1860

ggccucgaga ucugcugcua cgggcccuuc acgaacaugc ccaccgacca gcuggagugg     1920

augguccagc ugugcggcgc gagcguggug aaggagcucu ccagcuucac ccuggggacc     1980

ggcguccacc cgaucguggu gguccagccc gacgccugga ccgaggacaa cggguuccac     2040

gccaucggcc agaugugcga ggcccccgug gugacgcggg aguggguccu ggacuccgug     2100

gcgcucuacc agugccagga gcuggacacc uaccugaucc cccagauccc gcacagccac     2160

uacuga                                                                2166


<210>  674
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__EAW60923

<400>  674
auggaccucu ccgcccuccg cgucgaggag guccagaacg ucaucaacgc caugcagaag       60

auccucgagu gccccaucug ccucgagcuc aucaaggagc ccgucuccac caagugcgac      120

cacaucuucu gcaaguucug caugcucaag cuccucaacc agaagaaggg ccccucccag      180

ugcccccucu gcaagaacga caucaccaag cgcucccucc aggaguccac ccgcuucucc      240

cagcucgucg aggagcuccu caagaucauc ugcgccuucc agcucgacac cggccucgag      300

uacgccaacu ccuacaacuu cgccaagaag gagaacaacu cccccgagca ccucaaggac      360

gaggucucca ucauccaguc caugggcuac cgcaaccgcg ccaagcgccu ccuccagucc      420

gagcccgaga accccucccu ccaggagacc ucccucuccg uccagcucuc caaccucggc      480

accguccgca cccuccgcac caagcagcgc auccagcccc agaagaccuc cgucuacauc      540

gagcucggcu ccgacuccuc cgaggacacc gucaacaagg ccaccuacug cuccgucggc      600

gaccaggagc uccuccagau caccccccag ggcacccgcg acgagaucuc ccucgacucc      660

gccaagaagg gcgaggccgc cuccggcugc gaguccgaga ccuccgucuc cgaggacugc      720

uccggccucu ccucccaguc cgacauccuc accacccagc agcgcgacac caugcagcac      780

aaccucauca agcuccagca ggagauggcc gagcucgagg ccguccucga gcagcacggc      840

ucccagcccu ccaacuccua ccccuccauc aucuccgacu ccuccgcccu cgaggaccuc      900

cgcaaccccg agcaguccac cuccgagaag gccguccuca ccucccagaa guccuccgag      960

uaccccaucu cccagaaccc cgagggccuc uccgccgaca aguucgaggu cuccgccgac     1020

uccuccaccu ccaagaacaa ggagcccggc gucgagcgcu ccucccccuc caagugcccc     1080

ucccucgacg accgcuggua caugcacucc ugcuccggcu cccuccagaa ccgcaacuac     1140

cccucccagg aggagcucau caaggucguc gacgucgagg agcagcagcu cgaggagucc     1200

ggcccccacg accucaccga gaccuccuac cucccccgcc aggaccucga gggcaccccc     1260

uaccucgagu ccggcaucuc ccucuucucc gacgaccccg aguccgaccc cuccgaggac     1320

cgcgcccccg aguccgcccg cgucggcaac auccccuccu ccaccuccgc ccucaagguc     1380

ccccagcuca aggucgccga guccgcccag ucccccgccg ccgcccacac caccgacacc     1440

gccggcuaca acgccaugga ggaguccguc ucccgcgaga agcccgagcu caccgccucc     1500

accgagcgcg ucaacaagcg cauguccaug gucgucuccg gccucacccc cgaggaguuc     1560

augcucgucu acaaguucgc ccgcaagcac cacaucaccc ucaccaaccu caucaccgag     1620

gagaccaccc acgucgucau gaagaccgac gccgaguucg ucugcgagcg cacccucaag     1680

uacuuccucg gcaucgccgg cggcaagugg gucgucuccu acuucugggu cacccagucc     1740

aucaaggagc gcaagaugcu caacgagcac gacuucgagg uccgcggcga cgucgucaac     1800

ggccgcaacc accagggccc caagcgcgcc cgcgaguccc aggaccgcaa gaucuuccgc     1860

ggccucgaga ucugcugcua cggccccuuc accaacaugc ccaccgacca gcucgagugg     1920

augguccagc ucugcggcgc cuccgucguc aaggagcucu ccuccuucac ccucggcacc     1980

ggcguccacc ccaucgucgu cguccagccc gacgccugga ccgaggacaa cggcuuccac     2040

gccaucggcc agaugugcga ggcccccguc gucacccgcg aguggguccu cgacuccguc     2100

gcccucuacc agugccagga gcucgacacc uaccucaucc cccagauccc ccacucccac     2160

uacuga                                                                2166


<210>  675
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__EAW60923

<400>  675
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuugagu gccccauaug ucuggaauug aucaaagagc cuguguccac caagugcgau      120

cacauuuucu guaaauuuug cauguuaaag cugcuaaacc agaaaaaggg cccaucucag      180

uguccgcucu gcaagaauga caucacaaaa aggucacugc aggaaaguac ucgguucagc      240

caacuuguag aggagcuguu gaagauuauc ugugcauuuc agcucgauac ggggcuggaa      300

uacgccaacu ccuauaauuu cgcgaaaaag gagaacaauu cucccgaaca ucugaaagac      360

gaggugucga uaauccaguc aaugggauac cgcaaccgag cuaagcgucu cuuacagagc      420

gagccugaaa auccaagucu gcaagagacc ucccuuucug uccaguugag caaccugggu      480

acagugagaa cucuaaggac caagcagcgg auucagcccc agaaaacauc cguuuauauc      540

gaacucggcu cagauaguag cgaggacacc gugaauaagg ccacuuacug cucugucggg      600

gaucaagaac ugcuucagau uacaccucaa ggaacccgcg acgagaucuc ccuggauuca      660

gccaaaaagg gcgaggcagc uagcgguugu gaaagugaga cgucuguguc cgaagacugc      720

agcggguugu cgucucaguc cgauauacuc acuacccagc agagagacac aaugcaacac      780

aaccugauua aauuacagca ggagauggca gaacuggagg ccguacucga gcagcaugga      840

ucacaaccaa guaauagcua ucccuccauc auuucugaua gcucagcucu ugaagaccug      900

aggaacccug agcagaguac uuccgaaaag gccguuuuga ccagccagaa aucuucagag      960

uacccaauca gucagaaucc ggaaggccua agcgcggaca aguuugaggu guccgcagau     1020

ucuucgacaa gcaagaacaa agagcccggc gucgaacggu ccucaccuag uaagugucca     1080

ucucuggacg aucgcuggua uaugcacagc ugcuccgggu cacuccaaaa ccgaaauuac     1140

cccagccagg aggaacugau caaaguggug gacgucgagg agcagcagcu ugaagagucu     1200

ggaccucaug aucugaccga aacguccuac uugccaagac aagaccucga ggguacuccc     1260

uaucuggaaa guggcauuag cuuauucucu gaugacccgg aguccgaucc uucagaggac     1320

agggcccccg aaagugcucg gguugggaac auaccaagcu cgacauccgc ccugaaggug     1380

ccucagcuaa aaguagcaga gucugcucag agccccgccg cggcccacac cacugauaca     1440

gcaggauaca augcuaugga agagucagug agucgugaaa agccagagcu caccgccucc     1500

acggagcgcg ucaacaagag aaugucuaug gugguuagcg gccugacccc cgaagaguuu     1560

augcuugugu auaaauucgc uaggaagcac cauaucacau ugacuaaucu gauuaccgaa     1620

gagacaacuc acgucgugau gaaaaccgac gccgaauuug uaugcgagcg gacacucaag     1680

uacuuccugg guaucgcagg gggaaaaugg guuguguccu auuuuugggu cacccaauca     1740

auaaaggagc gaaagaugcu uaacgaacau gacuucgagg ugcgcggcga ugucgugaau     1800

ggcagaaacc accaggggcc uaaaagggcc cgggaaagcc aggaccgcaa gauuuuuaga     1860

ggacuggaga ucuguugcua cgguccauuc acuaauaugc cgacggauca guuggagugg     1920

augguucaac ucuguggcgc uaguguggua aaagaacugu cuuccuucac auuagggacc     1980

ggaguccacc ccaucguggu ugugcagccu gacgcgugga cugaggauaa cggcuuucau     2040

gcaauugguc agaugugcga agccccaguc gugaccaggg aguggguacu ggacagcgug     2100

gcucuauauc agugucaaga acucgauaca uaccugaucc cccagauucc ucacucgcau     2160

uacuga                                                                2166


<210>  676
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__EAW60923

<400>  676
auggaccuga gcgcccugag aguggaggag gugcagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcug aucaaggagc ccgugagcac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcugaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag agaagccugc aggagagcac cagauucagc      240

cagcuggugg aggagcugcu gaagaucauc ugcgccuucc agcuggacac cggccuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaaca gccccgagca ccugaaggac      360

gaggugagca ucauccagag caugggcuac agaaacagag ccaagagacu gcugcagagc      420

gagcccgaga accccagccu gcaggagacc agccugagcg ugcagcugag caaccugggc      480

accgugagaa cccugagaac caagcagaga auccagcccc agaagaccag cguguacauc      540

gagcugggca gcgacagcag cgaggacacc gugaacaagg ccaccuacug cagcgugggc      600

gaccaggagc ugcugcagau caccccccag ggcaccagag acgagaucag ccuggacagc      660

gccaagaagg gcgaggccgc cagcggcugc gagagcgaga ccagcgugag cgaggacugc      720

agcggccuga gcagccagag cgacauccug accacccagc agagagacac caugcagcac      780

aaccugauca agcugcagca ggagauggcc gagcuggagg ccgugcugga gcagcacggc      840

agccagccca gcaacagcua ccccagcauc aucagcgaca gcagcgcccu ggaggaccug      900

agaaaccccg agcagagcac cagcgagaag gccgugcuga ccagccagaa gagcagcgag      960

uaccccauca gccagaaccc cgagggccug agcgccgaca aguucgaggu gagcgccgac     1020

agcagcacca gcaagaacaa ggagcccggc guggagagaa gcagccccag caagugcccc     1080

agccuggacg acagauggua caugcacagc ugcagcggca gccugcagaa cagaaacuac     1140

cccagccagg aggagcugau caagguggug gacguggagg agcagcagcu ggaggagagc     1200

ggcccccacg accugaccga gaccagcuac cugcccagac aggaccugga gggcaccccc     1260

uaccuggaga gcggcaucag ccuguucagc gacgaccccg agagcgaccc cagcgaggac     1320

agagcccccg agagcgccag agugggcaac auccccagca gcaccagcgc ccugaaggug     1380

ccccagcuga agguggccga gagcgcccag agccccgccg ccgcccacac caccgacacc     1440

gccggcuaca acgccaugga ggagagcgug agcagagaga agcccgagcu gaccgccagc     1500

accgagagag ugaacaagag aaugagcaug guggugagcg gccugacccc cgaggaguuc     1560

augcuggugu acaaguucgc cagaaagcac cacaucaccc ugaccaaccu gaucaccgag     1620

gagaccaccc acguggugau gaagaccgac gccgaguucg ugugcgagag aacccugaag     1680

uacuuccugg gcaucgccgg cggcaagugg guggugagcu acuucugggu gacccagagc     1740

aucaaggaga gaaagaugcu gaacgagcac gacuucgagg ugagaggcga cguggugaac     1800

ggcagaaacc accagggccc caagagagcc agagagagcc aggacagaaa gaucuucaga     1860

ggccuggaga ucugcugcua cggccccuuc accaacaugc ccaccgacca gcuggagugg     1920

auggugcagc ugugcggcgc cagcguggug aaggagcuga gcagcuucac ccugggcacc     1980

ggcgugcacc ccaucguggu ggugcagccc gacgccugga ccgaggacaa cggcuuccac     2040

gccaucggcc agaugugcga ggcccccgug gugaccagag agugggugcu ggacagcgug     2100

gcccuguacc agugccagga gcuggacacc uaccugaucc cccagauccc ccacagccac     2160

uacuga                                                                2166


<210>  677
<211>  2166
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__EAW60923

<400>  677
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuggagu gccccaucug ucuugaacug auuaaagagc cuguguccac caagugcgau      120

cacaucuucu guaaauuuug caugcucaag cugcuuaacc agaaaaaggg cccgucucag      180

uguccccugu gcaagaauga cauuacaaaa cggagccucc aggaauccac gcgcuucucu      240

caacuggugg aggagcugcu caagaucauc ugugccuuuc agcuggauac cgggcuugaa      300

uacgcgaaca gcuauaauuu cgcuaaaaag gagaacaauu ccccugaaca ucugaaagac      360

gaggucucua uuauccagag caugggauac agaaaccggg ccaagcgccu ccugcagucc      420

gagcccgaaa auccuagccu ucaagagaca ucucuguccg ugcagcucag caaccugggc      480

accguuagaa cacugcggac caagcagcgc auucagcccc agaaaacauc uguguauauc      540

gaacucgggu ccgauagcuc ugaggacacc gucaauaagg ccacguacug cuccguggga      600

gaucaagaac ugcuucagau uaccccucaa ggcacaagag acgagaucag ccuggauucc      660

gcuaaaaagg gggaggccgc uucuggaugu gaaagcgaga ccuccguuag cgaagacugc      720

ucuggccucu ccagccaguc ugauauucug acaacccagc agcgggacac gaugcaacac      780

aaccuuauca aacugcagca ggagauggcc gaacucgagg cggugcugga gcagcauggc      840

agccaaccgu ccaauucuua ucccagcauc auuuccgaua gcucugcccu ggaagaccuc      900

cgcaacccug agcaguccac aagcgaaaag gcuguccuga ccucucagaa auccagcgag      960

uaccccaucu cccagaaucc ugaagggcuu ucugccgaca aguuugaggu gagcgcugau     1020

uccucuacaa gcaagaacaa agagcccgga guggaaagau ccagcccguc uaaguguccu     1080

ucccuggacg aucgguggua uaugcacagc ugcucuggcu cccuccaaaa ccgcaauuac     1140

cccagccagg aggaacugau uaaagucguu gacguggagg agcagcagcu ugaagagucu     1200

gggccucaug aucugaccga aaccagcuac cuccccagac aagaccugga gggaacaccc     1260

uaucuggaau ccggcaucag ccucuucucu gaugacccug aguccgaucc gagcgaggac     1320

cgggcccccg aauccgcgcg cguggggaac auuccuucua gcacguccgc ccugaagguc     1380

ccccagcuua aaguggcuga gucugcccag agcccugcug ccgcccacac cacagauacc     1440

gcuggauaca augcgaugga agaguccguu ucuagagaaa agcccgagcu gacagccagc     1500

accgagcggg ugaacaagag aauguccaug gucgugagcg gccucacgcc ggaagaguuu     1560

augcugguuu auaaauucgc ucgcaagcac cauaucacac ugaccaaucu uaucaccgaa     1620

gagacaaccc acguggucau gaaaacagac gccgaauuug ugugcgagcg gacgcucaag     1680

uacuuccugg gcauugccgg gggaaaaugg gucgugucuu auuuuugggu uacccaaucc     1740

aucaaggaga gaaagaugcu gaacgaacau gacuucgagg ugcgcggcga ugucgugaau     1800

gggcggaacc accagggacc uaaaagagcu cgcgaaagcc aggaccggaa gauuuuuaga     1860

ggccucgaga ucuguugcua cgggcccuuc acaaauaugc cuaccgauca gcuggagugg     1920

augguucaac uuuguggagc cucugugguc aaagaacugu ccagcuucac acucggcacc     1980

ggcgugcacc ccauuguggu uguccagccu gacgcgugga cggaggauaa cggguuucau     2040

gcuaucggac agaugugcga agcccccgug gugacccgcg aguggguccu ggacucugug     2100

gcccuguauc agugucaaga acuugauaca uaccucaucc cgcagauucc ucacucccau     2160

uacuga                                                                2166


<210>  678
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__A0A068BFX7

<400>  678

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val 
1               5                   10      


<210>  679
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__AIC83575

<400>  679
auggauuuau cugcucuucg cguugaagaa guauaa                                 36


<210>  680
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__AIC83575

<400>  680
auggaccuga gcgcccuccg cguggaggag gucuga                                 36


<210>  681
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__AIC83575

<400>  681
auggaccucu ccgcccuccg cgucgaggag gucuga                                 36


<210>  682
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__AIC83575

<400>  682
auggaccuga gcgcccucag aguggaggaa gucuga                                 36


<210>  683
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__AIC83575

<400>  683
auggaccuga gcgcccugag aguggaggag guguga                                 36


<210>  684
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__AIC83575

<400>  684
auggaccuga gcgcccucag aguggaggaa gucuga                                 36


<210>  685
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__C6YB45

<400>  685

Met Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly 
1               5                   10                  15      


Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp Val Thr Gln Ser 
            20                  25                  30          


Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val Arg Gly 
        35                  40                  45              


Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala Arg Glu 
    50                  55                  60                  


Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly 
65                  70                  75                  80  


Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val Gln Leu 
                85                  90                  95      


Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr 
            100                 105                 110         


Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr Glu Asp 
        115                 120                 125             


Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val Val Thr 
    130                 135                 140                 


Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu 
145                 150                 155                 160 


Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr 
                165                 170             


<210>  686
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__ABC59810

<400>  686
auggaugcug aguuugugug ugaacggaca cugaaauauu uucuaggaau ugcgggagga       60

aaauggguag uuagcuauuu cugggugacc cagucuauua aagaaagaaa aaugcugaau      120

gagcaugauu uugaagucag aggagaugug gucaauggaa gaaaccacca agguccaaag      180

cgagcaagag aaucccagga cagaaagauc uucagggggc uagaaaucug uugcuauggg      240

cccuucacca acaugcccac agaucaacug gaauggaugg uacagcugug uggugcuucu      300

guggugaagg agcuuucauc auucacccuu ggcacaggug uccacccaau ugugguugug      360

cagccagaug ccuggacaga ggacaauggc uuccaugcaa uugggcagau gugugaggca      420

ccugugguga cccgagagug gguguuggac aguguagcac ucuaccagug ccaggagcug      480

gacaccuacc ugauacccca gaucccccac agccacuacu ga                         522


<210>  687
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__ABC59810

<400>  687
auggacgccg aguucgugug cgagcgcacc cugaaguacu uccucggcau cgccgggggc       60

aagugggucg ugagcuacuu cugggugacc caguccauca aggagcggaa gaugcugaac      120

gagcacgacu ucgagguccg cggggacgug gugaacggcc ggaaccacca ggggcccaag      180

cgcgcgcggg agagccagga ccgcaagauc uuccggggcc uggagaucug cugcuacggc      240

ccguucacga acaugcccac cgaccagcuc gaguggaugg uccagcugug cggggccucc      300

guggugaagg agcugagcuc cuucacccuc ggcaccgggg uccaccccau cguggugguc      360

cagcccgacg ccuggacgga ggacaacggc uuccacgcca ucgggcagau gugcgaggcc      420

ccggugguga cccgcgagug gguccuggac agcguggcgc uguaccagug ccaggagcuc      480

gacaccuacc ugauccccca gaucccccac ucccacuacu ga                         522


<210>  688
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__ABC59810

<400>  688
auggacgccg aguucgucug cgagcgcacc cucaaguacu uccucggcau cgccggcggc       60

aagugggucg ucuccuacuu cugggucacc caguccauca aggagcgcaa gaugcucaac      120

gagcacgacu ucgagguccg cggcgacguc gucaacggcc gcaaccacca gggccccaag      180

cgcgcccgcg agucccagga ccgcaagauc uuccgcggcc ucgagaucug cugcuacggc      240

cccuucacca acaugcccac cgaccagcuc gaguggaugg uccagcucug cggcgccucc      300

gucgucaagg agcucuccuc cuucacccuc ggcaccggcg uccaccccau cgucgucguc      360

cagcccgacg ccuggaccga ggacaacggc uuccacgcca ucggccagau gugcgaggcc      420

cccgucguca cccgcgagug gguccucgac uccgucgccc ucuaccagug ccaggagcuc      480

gacaccuacc ucauccccca gaucccccac ucccacuacu ga                         522


<210>  689
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__ABC59810

<400>  689
auggacgccg aguucgugug cgaaagaacc cugaaguacu uucucggcau cgcuggggga       60

aaaugggucg uuagcuauuu cugggugaca caguccauua aggagaggaa aaugcuuaac      120

gaacacgauu uugagguacg gggugacgug gucaauggcc gcaaccauca agggcccaag      180

cgagcacgug aaucucagga uagaaaaaua uucaggggac uggagaucug uugcuacggc      240

ccuuuuacua auaugccaac ggaccaguug gaguggaugg ugcaguuaug uggugccuca      300

guugugaagg aacugaguag cuucacccua gggacaggag uccacccgau ugugguaguu      360

caacccgaug cguggacuga ggacaacggc uuucaugcua ucggccagau gugcgaagcc      420

ccugugguca cccgggagug ggugcucgau uccguggcac uguaucagug ucaggagcuu      480

gacacauacc ugauuccaca aaucccccac ucucauuauu ga                         522


<210>  690
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__ABC59810

<400>  690
auggacgccg aguucgugug cgagagaacc cugaaguacu uccugggcau cgccggcggc       60

aagugggugg ugagcuacuu cugggugacc cagagcauca aggagagaaa gaugcugaac      120

gagcacgacu ucgaggugag aggcgacgug gugaacggca gaaaccacca gggccccaag      180

agagccagag agagccagga cagaaagauc uucagaggcc uggagaucug cugcuacggc      240

cccuucacca acaugcccac cgaccagcug gaguggaugg ugcagcugug cggcgccagc      300

guggugaagg agcugagcag cuucacccug ggcaccggcg ugcaccccau cgugguggug      360

cagcccgacg ccuggaccga ggacaacggc uuccacgcca ucggccagau gugcgaggcc      420

cccgugguga ccagagagug ggugcuggac agcguggccc uguaccagug ccaggagcug      480

gacaccuacc ugauccccca gaucccccac agccacuacu ga                         522


<210>  691
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__ABC59810

<400>  691
auggacgccg aguucgugug cgaaagaacc cugaaguacu uucucggcau cgcuggggga       60

aaaugggucg uuagcuauuu cugggugaca caguccauua aggagcggaa aaugcugaac      120

gaacacgauu uugaggugcg cggcgacguc gugaauggga gaaaccauca aggacccaag      180

cgggcccgcg aaucucagga uagaaaaauc uuccggggcc uugagauuug uugcuacggg      240

ccuuuuacga auaugccgac cgaccagcug gaguggaugg uucagcucug uggagcgagc      300

guggucaagg aacuguccuc uuucacacuu ggcaccggcg ugcaccccau cguugugguc      360

caaccugaug cuuggacaga ggacaacggg uuucaugcca uuggacagau gugcgaagcc      420

cccgugguga cccgcgagug gguccuggau agcguugcuc ucuaucagug ucaggagcug      480

gacacauacc ugaucccuca aaucccccac ucccauuauu ga                         522


<210>  692
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__C6YB47

<400>  692

Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln 
1               5                   10                  15      


Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu 
            20                  25                  30          


Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp 
        35                  40                  45              


Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp 
    50                  55                  60                  


Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg 
65                  70                  75                  80  


Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu 
                85                  90                  95      


Lys Val Ala Glu Ser Ala Gln Gly Pro Ala Ala Ala His Thr Thr Asp 
            100                 105                 110         


Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro 
        115                 120                 125             


Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val 
    130                 135                 140                 


Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala 
145                 150                 155                 160 


Arg Lys His His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr 
                165                 170                 175     


His Val Val Met Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu 
            180                 185                 190         


Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe 
        195                 200                 205             


Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp 
    210                 215                 220                 


Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro 
225                 230                 235                 240 


Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu 
                245                 250                 255     


Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu 
            260                 265                 270         


Trp Met Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser 
        275                 280                 285             


Phe Thr Leu Gly Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp 
    290                 295                 300                 


Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu 
305                 310                 315                 320 


Thr Pro Val Val Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr 
                325                 330                 335     


Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser 
            340                 345                 350         


His Tyr 
        


<210>  693
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__ABC88652

<400>  693
augcacaguu gcucugggag ucuucagaau agaaacuacc caucucaaga ggagcucauu       60

aagguuguug auguggagga gcaacagcug gaagagucug ggccacacga uuugacggaa      120

acaucuuacu ugccaaggca agaucuagag ggaaccccuu accuggaauc uggaaucagc      180

cucuucucug augacccuga aucugauccu ucugaagaca gagccccaga gucagcucgu      240

guuggcaaca uaccaucuuc aaccucugca uugaagguuc cccaauugaa aguugcagaa      300

ucugcccagg guccagcugc ugcucacacu acugauacug cuggguauaa ugcaauggaa      360

gaaaguguga gcagggagaa gccagaauug acagcuucaa cagaaagggu caacaaaaga      420

auguccaugg uggugucugg ccugacccca gaagaauuua ugcucgugua caaguuugcc      480

agaaaacacc acaucacuuu aacuaaucua auuacugaag agacuacuca uguuguuaug      540

aaaacagaug cugaguuugu gugugaacgg acacugaaau auuuucuagg aauugcggga      600

ggaaaauggg uaguuagcua uuucugggug acccagucua uuaaagaaag aaaaaugcug      660

aaugagcaug auuuugaagu cagaggagau guggucaaug gaagaaacca ccaaggucca      720

aagcgagcaa gagaauccca ggacagaaag aucuucaggg ggcuagaaau cuguugcuau      780

gggcccuuca ccaacaugcc cacagaucaa cuggaaugga ugguacagcu guguggugcu      840

ucugugguga aggagcuuuc aucauucacc cuuggcacag guguccaccc aauugugguu      900

gugcagccag augccuggac agaggacaau ggcuuccaug caauugggca gaugugugag      960

acaccugugg ugacccgaga guggguguug gacaguguag cacucuacca gugccaggag     1020

cuggacaccu accugauacc ccagaucccc cacagucacu acuga                     1065


<210>  694
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__ABC88652

<400>  694
augcacagcu gcuccggcag ccugcagaac cgcaacuacc ccucccagga ggagcucauc       60

aagguggucg acguggagga gcagcagcug gaggagagcg ggccgcacga ccugaccgag      120

accuccuacc ucccccggca ggaccuggag ggcacgcccu accuggagag cgggaucucc      180

cucuucagcg acgaccccga guccgacccg agcgaggacc gcgcccccga guccgcccgg      240

gugggcaaca uccccagcuc caccagcgcg cugaaggucc cccagcugaa gguggccgag      300

uccgcccagg ggccggccgc cgcgcacacc accgacacgg ccggcuacaa cgccauggag      360

gagagcgugu cccgcgagaa gcccgagcuc accgccagca ccgagcgggu caacaagcgc      420

auguccaugg uggugagcgg ccugaccccc gaggaguuca ugcuggucua caaguucgcg      480

cggaagcacc acaucacgcu caccaaccug aucaccgagg agaccacgca cguggugaug      540

aagaccgacg ccgaguucgu cugcgagcgc acccugaagu acuuccucgg gaucgccggc      600

gggaaguggg uggugagcua cuucuggguc acccagucca ucaaggagcg gaagaugcug      660

aacgagcacg acuucgaggu gcgcggcgac guggucaacg ggcggaacca ccagggcccc      720

aagcgcgccc gggagagcca ggaccgcaag aucuuccggg gccuggagau cugcugcuac      780

gggccguuca cgaacaugcc caccgaccag cucgagugga uggugcagcu gugcggcgcc      840

uccgugguca aggagcugag cuccuucacc cucgggaccg gcgugcaccc caucgugguc      900

gugcagcccg acgcguggac ggaggacaac ggcuuccacg ccaucgggca gaugugcgag      960

accccggucg ugacccgcga gugggugcug gacagcgucg cccuguacca gugccaggag     1020

cucgacaccu accugauccc ccagaucccc cacucccacu acuga                     1065


<210>  695
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__ABC88652

<400>  695
augcacuccu gcuccggcuc ccuccagaac cgcaacuacc ccucccagga ggagcucauc       60

aaggucgucg acgucgagga gcagcagcuc gaggaguccg gcccccacga ccucaccgag      120

accuccuacc ucccccgcca ggaccucgag ggcacccccu accucgaguc cggcaucucc      180

cucuucuccg acgaccccga guccgacccc uccgaggacc gcgcccccga guccgcccgc      240

gucggcaaca uccccuccuc caccuccgcc cucaaggucc cccagcucaa ggucgccgag      300

uccgcccagg gccccgccgc cgcccacacc accgacaccg ccggcuacaa cgccauggag      360

gaguccgucu cccgcgagaa gcccgagcuc accgccucca ccgagcgcgu caacaagcgc      420

auguccaugg ucgucuccgg ccucaccccc gaggaguuca ugcucgucua caaguucgcc      480

cgcaagcacc acaucacccu caccaaccuc aucaccgagg agaccaccca cgucgucaug      540

aagaccgacg ccgaguucgu cugcgagcgc acccucaagu acuuccucgg caucgccggc      600

ggcaaguggg ucgucuccua cuucuggguc acccagucca ucaaggagcg caagaugcuc      660

aacgagcacg acuucgaggu ccgcggcgac gucgucaacg gccgcaacca ccagggcccc      720

aagcgcgccc gcgaguccca ggaccgcaag aucuuccgcg gccucgagau cugcugcuac      780

ggccccuuca ccaacaugcc caccgaccag cucgagugga ugguccagcu cugcggcgcc      840

uccgucguca aggagcucuc cuccuucacc cucggcaccg gcguccaccc caucgucguc      900

guccagcccg acgccuggac cgaggacaac ggcuuccacg ccaucggcca gaugugcgag      960

acccccgucg ucacccgcga guggguccuc gacuccgucg cccucuacca gugccaggag     1020

cucgacaccu accucauccc ccagaucccc cacucccacu acuga                     1065


<210>  696
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__ABC88652

<400>  696
augcacagcu gcuccggcuc ucugcagaac agaaauuacc ccucacaaga ggaacucauc       60

aagguggucg acguugagga acagcagcuu gaggaaagug ggccucauga ucugaccgag      120

acaagcuauu ugccaaggca ggacuuagag ggaacuccgu accuggaauc cgguauuucu      180

cuauucucgg augaccccga gucagauccu agcgaagacc gggccccaga gagugcucgc      240

gugggcaaca uacccuccuc uacgagcgca cucaaaguac cucaacugaa gguggccgag      300

uccgcgcagg ggccagcugc cgcacacacc acagauacug ccggauauaa ugcuauggaa      360

gagucaguca gucgagaaaa acccgagcuu accgcaagca cagaacgugu gaacaagaga      420

augucuaugg uuguguccgg ccugaccccu gaggaguuua uguuggucua caaauucgcc      480

aggaagcauc acaucacucu cacaaaucug auuaccgaag agacgacuca ugugguaaug      540

aagaccgacg cugaauuugu uugugagcgg acacugaaau auuuccucgg uaucgccggg      600

ggaaaguggg uggucucaua cuuuugggug acucagagca uuaaagaacg caagauguua      660

aacgagcacg auuucgaggu gagaggcgac gucguuaaug gcaggaacca ccaggggcca      720

aaacgggcgc gcgaaaguca agaucgaaag aucuuuagag gacuggagau augcuguuau      780

gguccguuca ccaauaugcc cacagaccag cuugaaugga uggugcaguu gugcggcgca      840

ucuguaguga aggagcuguc cagcuuuacc cuagggacgg gaguccaucc uaucgugguu      900

gugcagccag augccuggac ugaagacaac ggcuuccacg cuauugguca aaugugugag      960

acacccgucg ugaccaggga guggguacuc gacucgguug cccuguacca gugccaggaa     1020

cuugauacuu accugauccc ucaaauucca cauucucacu auuga                     1065


<210>  697
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__ABC88652

<400>  697
augcacagcu gcagcggcag ccugcagaac agaaacuacc ccagccagga ggagcugauc       60

aagguggugg acguggagga gcagcagcug gaggagagcg gcccccacga ccugaccgag      120

accagcuacc ugcccagaca ggaccuggag ggcacccccu accuggagag cggcaucagc      180

cuguucagcg acgaccccga gagcgacccc agcgaggaca gagcccccga gagcgccaga      240

gugggcaaca uccccagcag caccagcgcc cugaaggugc cccagcugaa gguggccgag      300

agcgcccagg gccccgccgc cgcccacacc accgacaccg ccggcuacaa cgccauggag      360

gagagcguga gcagagagaa gcccgagcug accgccagca ccgagagagu gaacaagaga      420

augagcaugg uggugagcgg ccugaccccc gaggaguuca ugcuggugua caaguucgcc      480

agaaagcacc acaucacccu gaccaaccug aucaccgagg agaccaccca cguggugaug      540

aagaccgacg ccgaguucgu gugcgagaga acccugaagu acuuccuggg caucgccggc      600

ggcaaguggg uggugagcua cuucugggug acccagagca ucaaggagag aaagaugcug      660

aacgagcacg acuucgaggu gagaggcgac guggugaacg gcagaaacca ccagggcccc      720

aagagagcca gagagagcca ggacagaaag aucuucagag gccuggagau cugcugcuac      780

ggccccuuca ccaacaugcc caccgaccag cuggagugga uggugcagcu gugcggcgcc      840

agcgugguga aggagcugag cagcuucacc cugggcaccg gcgugcaccc caucguggug      900

gugcagcccg acgccuggac cgaggacaac ggcuuccacg ccaucggcca gaugugcgag      960

acccccgugg ugaccagaga gugggugcug gacagcgugg cccuguacca gugccaggag     1020

cuggacaccu accugauccc ccagaucccc cacagccacu acuga                     1065


<210>  698
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__ABC88652

<400>  698
augcacagcu gcuccggcuc ucugcagaac agaaauuacc ccagccaaga ggaacucauc       60

aagguggucg acguugagga acagcagcug gaggaauccg ggccucauga ucuuaccgag      120

acaucuuauc ugccgcggca ggaccucgag ggaacgcccu accuggaaag cggcauuucc      180

cuuuucucug augacccuga gagcgauccc uccgaagacc gcgccccuga gagcgcuaga      240

guggggaaca uccccucuuc caccagcgcc cugaaagugc cucaacucaa ggucgcggag      300

ucugcucagg gaccggccgc cgcucacaca accgauacag ccggcuauaa ugcuauggaa      360

gaguccguga gccgggaaaa acccgagcug accgccucua cagaacgcgu uaacaagaga      420

auguccaugg uggucagcgg gcugaccccu gaggaguuua ugcucgugua caaauucgcg      480

cggaagcauc acauuacgcu gaccaaucuu aucacagaag agaccacaca uguugugaug      540

aagaccgacg ccgaauuugu cugugagcgc acgcugaaau auuuccucgg aauugcuggc      600

ggcaaguggg ugguguccua cuuuuggguc acacagucua ucaaagaaag aaagaugcug      660

aacgagcacg auuucgaggu ucgcggggac guggugaaug gacggaacca ccagggcccc      720

aaaagagccc gggaaagcca agaucgcaag aucuuuagag ggcuugagau uugcuguuau      780

ggaccuuuca ccaauaugcc cacagaccag cuggaaugga ugguccagcu cugcggcgcu      840

uccgugguua aggagcugag cucuuuuacc cuggggaccg gagugcaucc gaucgucgug      900

guucagccug augccuggac agaagacaac ggcuuccacg cgauuggcca aaugugugag      960

acgcccgugg ucacccggga gugggugcuc gacuccgucg cccuguacca gugccaggaa     1020

cuugauacau accugauccc ucaaauuccc cauagccacu auuga                     1065


<210>  699
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__G3XAC3

<400>  699

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            180                 185                 190         


Thr Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        195                 200                 205             


Leu Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu 
    210                 215                 220                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
225                 230                 235                 240 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                245                 250                 255     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu 
            260                 265                 270         


Thr Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly 
        275                 280                 285             


Leu Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys 
    290                 295                 300                 


Asn Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser 
305                 310                 315                 320 


Leu Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn 
                325                 330                 335     


Arg Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu 
            340                 345                 350         


Glu Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser 
        355                 360                 365             


Tyr Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly 
    370                 375                 380                 


Ile Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg 
385                 390                 395                 400 


Ala Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala 
                405                 410                 415     


Leu Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala 
            420                 425                 430         


Ala Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser 
        435                 440                 445             


Val Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn 
    450                 455                 460                 


Lys Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met 
465                 470                 475                 480 


Leu Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu 
                485                 490                 495     


Ile Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe 
            500                 505                 510         


Val Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys 
        515                 520                 525             


Trp Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys 
    530                 535                 540                 


Met Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly 
545                 550                 555                 560 


Arg Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys 
                565                 570                 575     


Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met 
            580                 585                 590         


Pro Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val 
        595                 600                 605             


Val Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile 
    610                 615                 620                 


Val Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala 
625                 630                 635                 640 


Ile Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu 
                645                 650                 655     


Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile 
            660                 665                 670         


Pro Gln Ile Pro His Ser His Tyr 
        675                 680 


<210>  700
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BRCA1/m__Homo_sapiens__EAW60939

<400>  700
auggauuuau cugcucuucg cguugaagaa guacaaaaug ucauuaaugc uaugcagaaa       60

aucuuagagu gucccaucug ucuggaguug aucaaggaac cugucuccac aaagugugac      120

cacauauuuu gcaaauuuug caugcugaaa cuucucaacc agaagaaagg gccuucacag      180

uguccuuuau guaagaauga uauaaccaaa aggagccuac aagaaaguac gagauuuagu      240

caacuuguug aagagcuauu gaaaaucauu ugugcuuuuc agcuugacac agguuuggag      300

uaugcaaaca gcuauaauuu ugcaaaaaag gaaaauaacu cuccugaaca ucuaaaagau      360

gaaguuucua ucauccaaag uaugggcuac agaaaccgug ccaaaagacu ucuacagagu      420

gaacccgaaa auccuuccuu gcaggaaacc agucucagug uccaacucuc uaaccuugga      480

acugugagaa cucugaggac aaagcagcgg auacaaccuc aaaagacguc ugucuacauu      540

gaauugggug aagcagcauc ugggugugag agugaaacaa gcgucucuga agacugcuca      600

gggcuauccu cucagaguga cauuuuaacc acucagcaga gggauaccau gcaacauaac      660

cugauaaagc uccagcagga aauggcugaa cuagaagcug uguuagaaca gcaugggagc      720

cagccuucua acagcuaccc uuccaucaua agugacucuu cugcccuuga ggaccugcga      780

aauccagaac aaagcacauc agaaaaagca guauuaacuu cacagaaaag uagugaauac      840

ccuauaagcc agaauccaga aggccuuucu gcugacaagu uugagguguc ugcagauagu      900

ucuaccagua aaaauaaaga accaggagug gaaaggucau ccccuucuaa augcccauca      960

uuagaugaua ggugguacau gcacaguugc ucugggaguc uucagaauag aaacuaccca     1020

ucucaagagg agcucauuaa gguuguugau guggaggagc aacagcugga agagucuggg     1080

ccacacgauu ugacggaaac aucuuacuug ccaaggcaag aucuagaggg aaccccuuac     1140

cuggaaucug gaaucagccu cuucucugau gacccugaau cugauccuuc ugaagacaga     1200

gccccagagu cagcucgugu uggcaacaua ccaucuucaa ccucugcauu gaaaguuccc     1260

caauugaaag uugcagaauc ugcccagagu ccagcugcug cucauacuac ugauacugcu     1320

ggguauaaug caauggaaga aagugugagc agggagaagc cagaauugac agcuucaaca     1380

gaaaggguca acaaaagaau guccauggug gugucuggcc ugaccccaga agaauuuaug     1440

cucguguaca aguuugccag aaaacaccac aucacuuuaa cuaaucuaau uacugaagag     1500

acuacucaug uuguuaugaa aacagaugcu gaguuugugu gugaacggac acugaaauau     1560

uuucuaggaa uugcgggagg aaaaugggua guuagcuauu ucugggugac ccagucuauu     1620

aaagaaagaa aaaugcugaa ugagcaugau uuugaaguca gaggagaugu ggucaaugga     1680

agaaaccacc aagguccaaa gcgagcaaga gaaucccagg acagaaagau cuucaggggg     1740

cuagaaaucu guugcuaugg gcccuucacc aacaugccca cagaucaacu ggaauggaug     1800

guacagcugu guggugcuuc uguggugaag gagcuuucau cauucacccu uggcacaggu     1860

guccacccaa uugugguugu gcagccagau gccuggacag aggacaaugg cuuccaugca     1920

auugggcaga ugugugaggc accuguggug acccgagagu ggguguugga caguguagca     1980

cucuaccagu gccaggagcu ggacaccuac cugauacccc agauccccca cagccacuac     2040

uga                                                                   2043


<210>  701
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BRCA1/m__Homo_sapiens__EAW60939

<400>  701
auggaccuga gcgcccuccg cguggaggag guccagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcuc aucaaggagc cgguguccac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcucaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag cggucccugc aggagagcac gcgcuucucc      240

cagcucgucg aggagcugcu gaagaucauc ugcgcguucc agcucgacac cgggcuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaacu cccccgagca ccugaaggac      360

gaggugagca ucauccaguc caugggcuac cggaaccgcg ccaagcggcu ccugcagagc      420

gagccggaga accccucccu gcaggagacc agccucuccg ugcagcugag caaccugggg      480

accguccgca cgcuccggac caagcagcgc auccagcccc agaagaccuc cguguacauc      540

gagcugggcg aggccgcgag cgggugcgag uccgagacca gcguguccga ggacugcagc      600

ggccugagcu cccagagcga cauccucacg acccagcagc gggacaccau gcagcacaac      660

cugaucaagc ugcagcagga gauggccgag cucgaggccg uccuggagca gcacggcucc      720

cagcccagca acuccuaccc gagcaucauc uccgacagcu ccgcccugga ggaccuccgc      780

aaccccgagc agagcaccuc cgagaaggcg gugcugacga gccagaaguc cagcgaguac      840

cccaucuccc agaaccccga ggggcugagc gccgacaagu ucgagguguc cgccgacagc      900

uccaccagca agaacaagga gccgggcguc gagcggagcu cccccagcaa gugccccucc      960

cucgacgacc gcugguacau gcacagcugc uccgggagcc ugcagaaccg gaacuacccc     1020

ucccaggagg agcugaucaa ggugguggac gucgaggagc agcagcucga ggagagcggc     1080

ccgcacgacc ugaccgagac cuccuaccug ccccgccagg accucgaggg gacgcccuac     1140

cuggagagcg gcaucucccu guucagcgac gaccccgagu ccgacccgag cgaggaccgg     1200

gcccccgagu ccgcccgcgu gggcaacauc cccagcucca ccagcgcgcu caaggugccc     1260

cagcugaagg ucgccgagag cgcccagucc ccggccgccg cgcacaccac cgacacggcc     1320

ggguacaacg ccauggagga gagcgugucc cgggagaagc ccgagcugac cgccagcacc     1380

gagcgcguga acaagcggau guccaugguc gugagcggcc ucacccccga ggaguucaug     1440

cugguguaca aguucgcccg caagcaccac aucacgcuga ccaaccucau caccgaggag     1500

accacgcacg ucgugaugaa gaccgacgcg gaguucgucu gcgagcggac ccugaaguac     1560

uuccugggga ucgccggcgg caagugggug guguccuacu ucugggucac ccagagcauc     1620

aaggagcgca agaugcugaa cgagcacgac uucgaggugc gcggggacgu ggucaacggc     1680

cggaaccacc aggggcccaa gcgcgcccgg gagucccagg accgcaagau cuuccggggc     1740

cucgagaucu gcugcuacgg gccguucacg aacaugccca ccgaccagcu ggaguggaug     1800

gugcagcugu gcggcgccag cguggucaag gagcucucca gcuucacccu gggcaccggg     1860

gugcacccca ucguggucgu gcagccggac gccuggacgg aggacaacgg cuuccacgcg     1920

aucgggcaga ugugcgaggc ccccgugguc acccgcgagu gggugcugga cuccguggcc     1980

cucuaccagu gccaggagcu ggacaccuac cugauccccc agauccccca cagccacuac     2040

uga                                                                   2043


<210>  702
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BRCA1/m__Homo_sapiens__EAW60939

<400>  702
auggaccucu ccgcccuccg cgucgaggag guccagaacg ucaucaacgc caugcagaag       60

auccucgagu gccccaucug ccucgagcuc aucaaggagc ccgucuccac caagugcgac      120

cacaucuucu gcaaguucug caugcucaag cuccucaacc agaagaaggg ccccucccag      180

ugcccccucu gcaagaacga caucaccaag cgcucccucc aggaguccac ccgcuucucc      240

cagcucgucg aggagcuccu caagaucauc ugcgccuucc agcucgacac cggccucgag      300

uacgccaacu ccuacaacuu cgccaagaag gagaacaacu cccccgagca ccucaaggac      360

gaggucucca ucauccaguc caugggcuac cgcaaccgcg ccaagcgccu ccuccagucc      420

gagcccgaga accccucccu ccaggagacc ucccucuccg uccagcucuc caaccucggc      480

accguccgca cccuccgcac caagcagcgc auccagcccc agaagaccuc cgucuacauc      540

gagcucggcg aggccgccuc cggcugcgag uccgagaccu ccgucuccga ggacugcucc      600

ggccucuccu cccaguccga cauccucacc acccagcagc gcgacaccau gcagcacaac      660

cucaucaagc uccagcagga gauggccgag cucgaggccg uccucgagca gcacggcucc      720

cagcccucca acuccuaccc cuccaucauc uccgacuccu ccgcccucga ggaccuccgc      780

aaccccgagc aguccaccuc cgagaaggcc guccucaccu cccagaaguc cuccgaguac      840

cccaucuccc agaaccccga gggccucucc gccgacaagu ucgaggucuc cgccgacucc      900

uccaccucca agaacaagga gcccggcguc gagcgcuccu cccccuccaa gugccccucc      960

cucgacgacc gcugguacau gcacuccugc uccggcuccc uccagaaccg caacuacccc     1020

ucccaggagg agcucaucaa ggucgucgac gucgaggagc agcagcucga ggaguccggc     1080

ccccacgacc ucaccgagac cuccuaccuc ccccgccagg accucgaggg cacccccuac     1140

cucgaguccg gcaucucccu cuucuccgac gaccccgagu ccgaccccuc cgaggaccgc     1200

gcccccgagu ccgcccgcgu cggcaacauc cccuccucca ccuccgcccu caaggucccc     1260

cagcucaagg ucgccgaguc cgcccagucc cccgccgccg cccacaccac cgacaccgcc     1320

ggcuacaacg ccauggagga guccgucucc cgcgagaagc ccgagcucac cgccuccacc     1380

gagcgcguca acaagcgcau guccaugguc gucuccggcc ucacccccga ggaguucaug     1440

cucgucuaca aguucgcccg caagcaccac aucacccuca ccaaccucau caccgaggag     1500

accacccacg ucgucaugaa gaccgacgcc gaguucgucu gcgagcgcac ccucaaguac     1560

uuccucggca ucgccggcgg caaguggguc gucuccuacu ucugggucac ccaguccauc     1620

aaggagcgca agaugcucaa cgagcacgac uucgaggucc gcggcgacgu cgucaacggc     1680

cgcaaccacc agggccccaa gcgcgcccgc gagucccagg accgcaagau cuuccgcggc     1740

cucgagaucu gcugcuacgg ccccuucacc aacaugccca ccgaccagcu cgaguggaug     1800

guccagcucu gcggcgccuc cgucgucaag gagcucuccu ccuucacccu cggcaccggc     1860

guccacccca ucgucgucgu ccagcccgac gccuggaccg aggacaacgg cuuccacgcc     1920

aucggccaga ugugcgaggc ccccgucguc acccgcgagu ggguccucga cuccgucgcc     1980

cucuaccagu gccaggagcu cgacaccuac cucauccccc agauccccca cucccacuac     2040

uga                                                                   2043


<210>  703
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BRCA1/m__Homo_sapiens__EAW60939

<400>  703
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuugagu gccccauaug ucuggaauug aucaaagagc cuguguccac caagugcgau      120

cacauuuucu guaaauuuug cauguuaaag cugcuaaacc agaaaaaggg cccaucucag      180

uguccgcucu gcaagaauga caucacaaaa aggucacugc aggaaaguac ucgguucagc      240

caacuuguag aggagcuguu gaagauuauc ugugcauuuc agcucgauac ggggcuggaa      300

uacgccaacu ccuauaauuu cgcgaaaaag gagaacaauu cucccgaaca ucugaaagac      360

gaggugucga uaauccaguc aaugggauac cgcaaccgag cuaagcgucu cuuacagagc      420

gagccugaaa auccaagucu gcaagagacc ucccuuucug uccaguugag caaccugggu      480

acagugagaa cucuaaggac caagcagcgg auucagcccc agaaaacauc cguuuauauc      540

gaacucggcg aggccgcauc agggugcgaa agugagacca gcgugucuga ggauuguucc      600

ggacugucaa gccaaaguga cauucuuacu acacagcaac gcgauaccau gcagcacaau      660

cugaucaagu ugcagcagga aauggccgag cucgaagcug uccuggagca acauggcucu      720

cagccuucca acagcuaccc aucgauaauu ucugacuccu cagcauuaga agaucugaga      780

aaucccgagc agaguacgag cgagaaagcc gugcucacuu cccagaaguc uagcgaauau      840

ccuaucucac aaaacccaga gggucuuagu gcugacaaau uugaaguauc cgccgauagc      900

ucuaccucaa agaauaaaga gccggggguu gaaaggagua gccccuccaa gugcccuucu      960

cuggacgauc ggugguacau gcacucgugu agcggauccu ugcagaaccg caacuaucca     1020

ucacaggagg agcuaauuaa gguggucgac guggaggaac agcaacugga agagaguggc     1080

ccccaugacc ucacagagac uucuuaccug ccucgacagg aucuugaagg caccccauac     1140

cuggagagcg ggaucuccuu guucucagac gaucccgaaa gcgacccguc ugaggauaga     1200

gcgccugaau ccgcaagggu gggaaauauc cccaguagca caucugcccu caaaguccca     1260

cagcugaagg uugcugaguc cgcccagagu ccugcagcug cccacaccac ggacacugcg     1320

gguuauaacg ccauggagga aucagugagc cgggagaaac ccgaauuaac agcaucgacc     1380

gagcguguaa auaagcgcau guccauggug gucucuggcc ugacuccaga agaguuuaug     1440

cuaguguaca aauucgcuag aaagcaccau auuacacuca ccaaccugau aacggaggaa     1500

accacacacg uugugaugaa gacugaugcc gaguuugucu gcgaaaggac ccuuaaauau     1560

uucuugggga ucgcuggagg caagugggug guaagcuacu uuuggguuac acaaucaauu     1620

aaagagcgga agaugcugaa ugaacaugac uucgaggugc gaggugaugu cgugaacggg     1680

cgcaaucacc agggacccaa aagagccagg gagagucagg accggaagau cuuucgcggc     1740

cucgaaauau gcuguuaugg cccuuucacu aacaugccaa ccgaucaacu ggaguggaug     1800

guccagcuuu gcggggcauc cgugguuaag gaacugucua gcuucacauu gggaaccggu     1860

gugcacccga uuguagucgu gcagcccgac gccuggacug aggacaaugg cuuucaugcu     1920

aucgggcaga ugugugaggc gccuguugug acgagagaau ggguccucga uuccguggca     1980

cuguaccaau gccaggaguu agacacauau cugaucccac agauucccca cucacauuac     2040

uga                                                                   2043


<210>  704
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BRCA1/m__Homo_sapiens__EAW60939

<400>  704
auggaccuga gcgcccugag aguggaggag gugcagaacg ugaucaacgc caugcagaag       60

auccuggagu gccccaucug ccuggagcug aucaaggagc ccgugagcac caagugcgac      120

cacaucuucu gcaaguucug caugcugaag cugcugaacc agaagaaggg ccccagccag      180

ugcccccugu gcaagaacga caucaccaag agaagccugc aggagagcac cagauucagc      240

cagcuggugg aggagcugcu gaagaucauc ugcgccuucc agcuggacac cggccuggag      300

uacgccaaca gcuacaacuu cgccaagaag gagaacaaca gccccgagca ccugaaggac      360

gaggugagca ucauccagag caugggcuac agaaacagag ccaagagacu gcugcagagc      420

gagcccgaga accccagccu gcaggagacc agccugagcg ugcagcugag caaccugggc      480

accgugagaa cccugagaac caagcagaga auccagcccc agaagaccag cguguacauc      540

gagcugggcg aggccgccag cggcugcgag agcgagacca gcgugagcga ggacugcagc      600

ggccugagca gccagagcga cauccugacc acccagcaga gagacaccau gcagcacaac      660

cugaucaagc ugcagcagga gauggccgag cuggaggccg ugcuggagca gcacggcagc      720

cagcccagca acagcuaccc cagcaucauc agcgacagca gcgcccugga ggaccugaga      780

aaccccgagc agagcaccag cgagaaggcc gugcugacca gccagaagag cagcgaguac      840

cccaucagcc agaaccccga gggccugagc gccgacaagu ucgaggugag cgccgacagc      900

agcaccagca agaacaagga gcccggcgug gagagaagca gccccagcaa gugccccagc      960

cuggacgaca gaugguacau gcacagcugc agcggcagcc ugcagaacag aaacuacccc     1020

agccaggagg agcugaucaa ggugguggac guggaggagc agcagcugga ggagagcggc     1080

ccccacgacc ugaccgagac cagcuaccug cccagacagg accuggaggg cacccccuac     1140

cuggagagcg gcaucagccu guucagcgac gaccccgaga gcgaccccag cgaggacaga     1200

gcccccgaga gcgccagagu gggcaacauc cccagcagca ccagcgcccu gaaggugccc     1260

cagcugaagg uggccgagag cgcccagagc cccgccgccg cccacaccac cgacaccgcc     1320

ggcuacaacg ccauggagga gagcgugagc agagagaagc ccgagcugac cgccagcacc     1380

gagagaguga acaagagaau gagcauggug gugagcggcc ugacccccga ggaguucaug     1440

cugguguaca aguucgccag aaagcaccac aucacccuga ccaaccugau caccgaggag     1500

accacccacg uggugaugaa gaccgacgcc gaguucgugu gcgagagaac ccugaaguac     1560

uuccugggca ucgccggcgg caagugggug gugagcuacu ucugggugac ccagagcauc     1620

aaggagagaa agaugcugaa cgagcacgac uucgagguga gaggcgacgu ggugaacggc     1680

agaaaccacc agggccccaa gagagccaga gagagccagg acagaaagau cuucagaggc     1740

cuggagaucu gcugcuacgg ccccuucacc aacaugccca ccgaccagcu ggaguggaug     1800

gugcagcugu gcggcgccag cguggugaag gagcugagca gcuucacccu gggcaccggc     1860

gugcacccca ucgugguggu gcagcccgac gccuggaccg aggacaacgg cuuccacgcc     1920

aucggccaga ugugcgaggc ccccguggug accagagagu gggugcugga cagcguggcc     1980

cuguaccagu gccaggagcu ggacaccuac cugauccccc agauccccca cagccacuac     2040

uga                                                                   2043


<210>  705
<211>  2043
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BRCA1/m__Homo_sapiens__EAW60939

<400>  705
auggaccuga gcgcccucag aguggaggaa guccagaacg uuaucaaugc uaugcaaaag       60

auucuggagu gccccaucug ucuugaacug auuaaagagc cuguguccac caagugcgau      120

cacaucuucu guaaauuuug caugcucaag cugcuuaacc agaaaaaggg cccgucucag      180

uguccccugu gcaagaauga cauuacaaaa cggagccucc aggaauccac gcgcuucucu      240

caacuggugg aggagcugcu caagaucauc ugugccuuuc agcuggauac cgggcuugaa      300

uacgcgaaca gcuauaauuu cgcuaaaaag gagaacaauu ccccugaaca ucugaaagac      360

gaggucucua uuauccagag caugggauac agaaaccggg ccaagcgccu ccugcagucc      420

gagcccgaaa auccuagccu ucaagagaca ucucuguccg ugcagcucag caaccugggc      480

accguuagaa cacugcggac caagcagcgc auucagcccc agaaaacauc uguguauauc      540

gaacucgggg aggccgcuuc cggaugcgaa agcgagaccu cugucuccga ggauuguagc      600

ggccuguccu cucaaagcga cauucuuacg acccagcaaa gagauacaau gcagcacaau      660

cugaucaagc uccagcagga aauggccgag cuggaagcug ugcuugagca acaugggucc      720

cagccuagca acucuuaccc guccauuauc agcgacucua gcgcccugga agaucuccgg      780

aaucccgagc aguccaccuc ugagaaagcg guucugacaa gccagaaguc cagcgaauau      840

ccuaucucuc aaaaccccga gggacugucc gccgacaaau uugaagugag cgcugauucu      900

uccaccagca agaauaaaga gccuggcguc gaacgcuccu cucccagcaa gugcccgucc      960

cucgacgaua gaugguacau gcacucuugu agcggcuccc ugcagaaccg gaacuauccu     1020

agccaggagg agcuuauuaa ggugguggac gucgaggaac agcaacugga agagucuggg     1080

ccccaugacc ucacggagac auccuaccug ccucgccagg aucuugaagg aacccccuac     1140

cuggagagcg gcaucucucu cuucuccgac gaucccgaaa gcgacccuuc ugaggauaga     1200

gccccggaaa gcgcucgggu ugggaauauu cccuccagca caucugcccu gaaagugccu     1260

cagcugaagg uggcggaguc cgcccagagc cccgcugccg cucacaccac cgacacagcc     1320

ggauauaacg ccauggagga auccgucucu cgcgagaaac cugaacucac ggcuagcacc     1380

gagagaguga auaagcggau guccaugguu gugucuggcc ugacacccga agaguuuaug     1440

cuugucuaca aauucgcgag aaagcaccau aucacccuga caaaccucau uaccgaggaa     1500

acgacacacg ugguuaugaa gaccgaugcc gaguuugugu gcgaacgcac ccugaaauau     1560

uuccugggga ucgcuggagg caaguggguc gugagcuacu uuugggucac acaauccauc     1620

aaagagcgga agaugcuuaa ugaacaugac uucgagguga gaggcgaugu ugugaacggg     1680

cgcaaucacc agggaccgaa acgggccaga gagucucagg accgcaagau uuuucggggc     1740

cucgaaaucu gcuguuaugg gccuuucacc aacaugccca cagaucaacu ggaguggaug     1800

guccagcugu gcggagccag cgugguuaag gaacucucca gcuucacgcu gggcaccggg     1860

gugcacccua uugucguggu gcagcccgac gcuuggacag aggacaaugg auuucaugcc     1920

aucggccaga ugugugaggc gccuguuguc accagagaau gggugcuuga uucuguggcu     1980

cuguaccaau gccaggagcu cgacacauau cugauucccc agaucccgca cucccauuac     2040

uga                                                                   2043


<210>  706
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BY55__Homo_sapiens__O95971

<400>  706

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  707
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BY55__Homo_sapiens__AAC72302

<400>  707
augcuguugg aacccggcag aggcugcugu gcccuggcca uccugcuggc aauuguggac       60

auccagucug guggaugcau uaacaucacc agcucagcuu cccaggaagg aacgcgacua      120

aacuuaaucu guacuguaug gcauaagaaa gaagaggcug agggguuugu aguguuuuug      180

ugcaaggaca ggucuggaga cuguucuccu gagaccaguu uaaaacagcu gagacuuaaa      240

agggauccug ggauagaugg uguuggugaa auaucaucuc aguugauguu caccauaagc      300

caagucacac cguugcacag ugggaccuac caguguugug ccagaagcca gaagucaggu      360

auccgccuuc agggccauuu uuucuccauu cuauucacag agacagggaa cuacacagug      420

acgggauuga aacaaagaca acaccuugag uucagccaua augaaggcac ucucaguuca      480

ggcuuccuac aagaaaaggu cuggguaaug cuggucacca gccuuguggc ccuucaagcu      540

uuguaa                                                                 546


<210>  708
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BY55__Homo_sapiens__AAC72302

<400>  708
augcugcucg agcccggccg cgggugcugc gcccuggcca uccugcucgc gaucguggac       60

auccagagcg gcgggugcau caacaucacc uccagcgccu cccaggaggg cacccggcug      120

aaccugaucu gcacggucug gcacaagaag gaggaggccg agggguucgu gguguuccuc      180

ugcaaggacc gcagcggcga cugcuccccg gagaccagcc ugaagcagcu gcggcucaag      240

cgcgaccccg gcaucgacgg ggucggcgag aucuccagcc agcugauguu caccaucucc      300

caggugacgc cccugcacag cgggaccuac cagugcugcg cccgguccca gaaguccggc      360

auccgccucc aggggcacuu cuucagcauc cuguucaccg agaccggcaa cuacaccgug      420

acgggccuga agcagcggca gcaccucgag uucagccaca acgaggggac ccuguccagc      480

ggcuuccugc aggagaaggu cugggugaug cucgugaccu cccuggucgc ccugcaggcg      540

cucuga                                                                 546


<210>  709
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BY55__Homo_sapiens__AAC72302

<400>  709
augcuccucg agcccggccg cggcugcugc gcccucgcca uccuccucgc caucgucgac       60

auccaguccg gcggcugcau caacaucacc uccuccgccu cccaggaggg cacccgccuc      120

aaccucaucu gcaccgucug gcacaagaag gaggaggccg agggcuucgu cgucuuccuc      180

ugcaaggacc gcuccggcga cugcuccccc gagaccuccc ucaagcagcu ccgccucaag      240

cgcgaccccg gcaucgacgg cgucggcgag aucuccuccc agcucauguu caccaucucc      300

caggucaccc cccuccacuc cggcaccuac cagugcugcg cccgcuccca gaaguccggc      360

auccgccucc agggccacuu cuucuccauc cucuucaccg agaccggcaa cuacaccguc      420

accggccuca agcagcgcca gcaccucgag uucucccaca acgagggcac ccucuccucc      480

ggcuuccucc aggagaaggu cugggucaug cucgucaccu cccucgucgc ccuccaggcc      540

cucuga                                                                 546


<210>  710
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BY55__Homo_sapiens__AAC72302

<400>  710
augcugcucg agcccggcag agggugcugu gcccuugcua uccuguuggc aauuguggac       60

auacagagcg gagguugcau caacauuacc uccucugccu cacaagaagg cacaagguua      120

aaucugaucu guacugucug gcacaagaaa gaggaagcgg agggguucgu uguguuucua      180

ugcaaggauc ggaguggaga cuguagcccu gaaacguccc ucaaacagcu gcgccuuaag      240

cgagauccag gcauugacgg uguaggggag aucucuucgc agcugauguu caccauauca      300

caggugacac cguugcauag cggaacuuac caaugcugug cucguaguca gaaauccggc      360

aucagacucc agggccacuu uuucucuauu cuguuuaccg agacagggaa cuauaccguc      420

acuggacuga agcagaggca acaucucgag uucagccaca augaagguac auuauccuca      480

ggcuuucugc aggaaaaggu guggguuaug cuugugacca guuuggucgc ccugcaggca      540

cuauga                                                                 546


<210>  711
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BY55__Homo_sapiens__AAC72302

<400>  711
augcugcugg agcccggcag aggcugcugc gcccuggcca uccugcuggc caucguggac       60

auccagagcg gcggcugcau caacaucacc agcagcgcca gccaggaggg caccagacug      120

aaccugaucu gcaccgugug gcacaagaag gaggaggccg agggcuucgu gguguuccug      180

ugcaaggaca gaagcggcga cugcagcccc gagaccagcc ugaagcagcu gagacugaag      240

agagaccccg gcaucgacgg cgugggcgag aucagcagcc agcugauguu caccaucagc      300

caggugaccc cccugcacag cggcaccuac cagugcugcg ccagaagcca gaagagcggc      360

aucagacugc agggccacuu cuucagcauc cuguucaccg agaccggcaa cuacaccgug      420

accggccuga agcagagaca gcaccuggag uucagccaca acgagggcac ccugagcagc      480

ggcuuccugc aggagaaggu gugggugaug cuggugacca gccugguggc ccugcaggcc      540

cuguga                                                                 546


<210>  712
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BY55__Homo_sapiens__AAC72302

<400>  712
augcugcucg agcccggcag agggugcugu gcccuggcua uccuucuggc cauuguggac       60

auccagagcg gaggcugcau uaacaucacc uccucugcga gccaagaagg gacacggcuc      120

aaucugauuu guacggucug gcacaagaaa gaggaagcug agggauucgu uguguuucuu      180

ugcaaggauc gcuccggcga cuguucuccu gaaaccagcc ugaaacagcu cagacugaag      240

cgggauccgg ggaucgacgg agugggcgag aucuccucuc agcugauguu cacaauuagc      300

caggucacac cccuccauuc cggcaccuac caaugcugug cccgcagcca gaaaucuggg      360

aucagacugc agggacacuu uuucuccauu cuuuuuaccg agacaggcaa cuauaccgug      420

acggggcuga agcagcggca acaucucgag uucagccaca augaaggaac ccugucuucc      480

ggcuuucuuc aggaaaaggu uugggugaug cuggucacaa gccucguggc ccugcaggcu      540

cuguga                                                                 546


<210>  713
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CAMEL__Homo_sapiens__O95987

<400>  713

Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu Met Ala Gln Gly Ala 
1               5                   10                  15      


Met Leu Ala Ala Gln Glu Arg Arg Val Pro Arg Ala Ala Glu Val Pro 
            20                  25                  30          


Gly Ala Gln Gly Gln Gln Gly Pro Arg Gly Arg Glu Glu Ala Pro Arg 
        35                  40                  45              


Gly Val Arg Met Ala Val Pro Leu Leu Arg Arg Met Glu Gly Ala Pro 
    50                  55                  60                  


Ala Gly Pro Gly Gly Arg Thr Ala Ala Cys Phe Ser Cys Thr Ser Arg 
65                  70                  75                  80  


Cys Leu Ser Arg Arg Pro Trp Lys Arg Ser Trp Ser Ala Gly Ser Cys 
                85                  90                  95      


Pro Gly Met Pro His Leu Ser Pro Asp Gln Gly Arg Phe 
            100                 105                 


<210>  714
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CAMEL__Homo_sapiens__CAA10193

<400>  714
augcugaugg cccaggaggc ccuggcauuc cugauggccc agggggcaau gcuggcggcc       60

caggagaggc gggugccacg ggcggcagag guccccgggg cgcaggggca gcaagggccu      120

cggggccgag aggaggcgcc ccgcgggguc cgcauggcgg ugccgcuucu gcgcaggaug      180

gaaggugccc cugcggggcc aggaggccgg acagccgccu gcuucaguug cacaucacga      240

ugccuuucuc gucgcccaug gaagcggagc ugguccgcag gauccugucc cgggaugccg      300

caccucuccc ccgaccaggg gcgguucuga                                       330


<210>  715
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CAMEL__Homo_sapiens__CAA10193

<400>  715
augcugaugg cccaggaggc ccucgcguuc cugauggccc agggcgccau gcuggccgcc       60

caggagcgcc gggugccccg cgcggccgag gucccggggg cccagggcca gcaggggccc      120

cggggccgcg aggaggcgcc ccgcggggug cggauggccg ugccccuccu gcggcgcaug      180

gagggcgccc cggccggccc cgggggccgg accgccgccu gcuucagcug caccucccgc      240

ugccugagcc ggcgccccug gaagcggucc uggagcgcgg gguccugccc cggcaugccg      300

caccucagcc ccgaccaggg gcgcuucuga                                       330


<210>  716
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CAMEL__Homo_sapiens__CAA10193

<400>  716
augcucaugg cccaggaggc ccucgccuuc cucauggccc agggcgccau gcucgccgcc       60

caggagcgcc gcgucccccg cgccgccgag guccccggcg cccagggcca gcagggcccc      120

cgcggccgcg aggaggcccc ccgcggcguc cgcauggccg ucccccuccu ccgccgcaug      180

gagggcgccc ccgccggccc cggcggccgc accgccgccu gcuucuccug caccucccgc      240

ugccucuccc gccgccccug gaagcgcucc ugguccgccg gcuccugccc cggcaugccc      300

caccucuccc ccgaccaggg ccgcuucuga                                       330


<210>  717
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CAMEL__Homo_sapiens__CAA10193

<400>  717
augcugaugg cccaggaggc ucucgcauuc cuuauggccc aaggcgcgau gcuggcugcc       60

caggaaagaa gggugccccg ggcagccgag gucccugggg cucagggaca gcaaggucca      120

cgcggccgag aagaggcacc gcgugggguu agaauggccg ugcccuuguu aaggcggaug      180

gaaggagcuc cugccggccc aggugggcgc accgcggcau gcuuuagcug uacauccaga      240

ugccugucua ggcggcccug gaagcgcuca uggagugccg gaagcugucc uggcaugcca      300

caccuauccc ccgaccaggg ccgauucuga                                       330


<210>  718
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CAMEL__Homo_sapiens__CAA10193

<400>  718
augcugaugg cccaggaggc ccuggccuuc cugauggccc agggcgccau gcuggccgcc       60

caggagagaa gagugcccag agccgccgag gugcccggcg cccagggcca gcagggcccc      120

agaggcagag aggaggcccc cagaggcgug agaauggccg ugccccugcu gagaagaaug      180

gagggcgccc ccgccggccc cggcggcaga accgccgccu gcuucagcug caccagcaga      240

ugccugagca gaagacccug gaagagaagc uggagcgccg gcagcugccc cggcaugccc      300

caccugagcc ccgaccaggg cagauucuga                                       330


<210>  719
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CAMEL__Homo_sapiens__CAA10193

<400>  719
augcugaugg cccaggaggc ucucgccuuc cugauggcgc aaggcgcuau gcuugccgcc       60

caggaaagac gggugccccg cgcugccgag gucccugggg cucagggaca gcaaggcccg      120

agagggcggg aagaggcgcc ccgcggaguu agaauggccg ugccucugcu ccggcgcaug      180

gaaggcgccc ccgcugggcc uggaggcaga accgccgcuu gcuuuagcug uacaucccgg      240

ugccugucuc gcagacccug gaagcggagc ugguccgccg gcucuugucc ugggaugccg      300

caccuuagcc ccgaccaggg acgcuucuga                                       330


<210>  720
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CASPA__Homo_sapiens__Q92851-4

<400>  720

Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Thr Lys Glu Glu Val Glu Arg Leu Leu Pro Thr Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Thr Glu Met Thr Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Thr Cys Leu Glu Asp Leu Cys Lys Thr 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Thr Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Thr Asp Val Lys Thr Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Gly Asn Arg Ala Thr Asn Gly Ala Pro Ser Leu Val Ser Arg Gly Met 
                245                 250                 255     


Gln Gly Ala Ser Ala Asn Thr Leu Asn Ser Glu Thr Ser Thr Lys Arg 
            260                 265                 270         


Ala Ala Val Tyr Arg Met Asn Arg Asn His Arg Gly Leu Cys Val Ile 
        275                 280                 285             


Val Asn Asn His Ser Phe Thr Ser Leu Lys Asp Arg Gln Gly Thr His 
    290                 295                 300                 


Lys Asp Ala Glu Ile Leu Ser His Val Phe Gln Trp Leu Gly Phe Thr 
305                 310                 315                 320 


Val His Ile His Asn Asn Val Thr Lys Val Glu Met Glu Met Val Leu 
                325                 330                 335     


Gln Lys Gln Lys Cys Asn Pro Ala His Ala Asp Gly Asp Cys Phe Val 
            340                 345                 350         


Phe Cys Ile Leu Thr His Gly Arg Phe Gly Ala Val Tyr Ser Ser Asp 
        355                 360                 365             


Glu Ala Leu Ile Pro Ile Arg Glu Ile Met Ser His Phe Thr Ala Leu 
    370                 375                 380                 


Gln Cys Pro Arg Leu Ala Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala 
385                 390                 395                 400 


Cys Gln Gly Glu Glu Ile Gln Pro Ser Val Ser Ile Glu Ala Asp Ala 
                405                 410                 415     


Leu Asn Pro Glu Gln Ala Pro Thr Ser Leu Gln Asp Ser Ile Pro Ala 
            420                 425                 430         


Glu Ala Asp Phe Leu Leu Gly Leu Ala Thr Val Pro Gly Tyr Val Ser 
        435                 440                 445             


Phe Arg His Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn 
    450                 455                 460                 


His Leu Lys Lys Leu Val Pro Arg His Glu Asp Ile Leu Ser Ile Leu 
465                 470                 475                 480 


Thr Ala Val Asn Asp Asp Val Ser Arg Arg Val Asp Lys Gln Gly Thr 
                485                 490                 495     


Lys Lys Gln Met Pro Gln Pro Ala Phe Thr Leu Arg Lys Lys Leu Val 
            500                 505                 510         


Phe Pro Val Pro Leu Asp Ala Leu Ser Leu 
        515                 520         


<210>  721
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CASPA__Homo_sapiens__CCDS2340.1

<400>  721
augaaaucuc aaggucaaca uugguauucc aguucagaua aaaacuguaa agugagcuuu       60

cgugagaagc uucugauuau ugauucaaac cugggggucc aagaugugga gaaccucaag      120

uuucucugca uaggauuggu ccccaacaag aagcuggaga aguccagcuc agccucagau      180

guuuuugaac aucucuuggc agaggaucug cugagugagg aagacccuuu cuuccuggca      240

gaacuccucu auaucauacg gcagaagaag cugcugcagc accucaacug uaccaaagag      300

gaaguggagc gacugcugcc cacccgacaa aggguuucuc uguuuagaaa ccugcucuac      360

gaacugucag aaggcauuga cucagagaac uuaaaggaca ugaucuuccu ucugaaagac      420

ucgcuuccca aaacugaaau gaccucccua aguuuccugg cauuucuaga gaaacaaggu      480

aaaauagaug aagauaaucu gacaugccug gaggaccucu gcaaaacagu uguaccuaaa      540

cuuuugagaa acauagagaa auacaaaaga gagaaagcua uccagauagu gacaccuccu      600

guagacaagg aagccgaguc guaucaagga gaggaagaac uaguuuccca aacagauguu      660

aagacauucu uggaagccuu accgcaggag uccuggcaaa auaagcaugc agguaguaau      720

gguaacagag ccacaaaugg ugcaccaagc cuggucucca gggggaugca aggagcaucu      780

gcuaacacuc uaaacucuga aaccagcaca aagagggcag cuguguacag gaugaaucgg      840

aaccacagag gccucugugu cauugucaac aaccacagcu uuaccucccu gaaggacaga      900

caaggaaccc auaaagaugc ugagauccug agucaugugu uccaguggcu uggguucaca      960

gugcauauac acaauaaugu gacgaaagug gaaauggaga ugguccugca gaagcagaag     1020

ugcaauccag cccaugccga cggggacugc uucguguucu guauucugac ccaugggaga     1080

uuuggagcug ucuacucuuc ggaugaggcc cucauuccca uucgggagau caugucucac     1140

uucacagccc ugcagugccc uagacuggcu gaaaaaccua aacucuuuuu cauccaggcc     1200

ugccaaggug aagagauaca gccuuccgua uccaucgaag cagaugcucu gaacccugag     1260

caggcaccca cuucccugca ggacaguauu ccugccgagg cugacuuccu acuuggucug     1320

gccacugucc caggcuaugu auccuuucgg cauguggagg aaggcagcug guauauucag     1380

ucucugugua aucaucugaa gaaauugguc ccaagacaug aagacaucuu auccauccuc     1440

acugcuguca acgaugaugu gagucgaaga guggacaaac agggaacaaa gaaacagaug     1500

ccccagccug cuuucacacu aaggaaaaaa cuaguauucc cugugccccu ggaugcacuu     1560

ucauuauag                                                             1569


<210>  722
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CASPA__Homo_sapiens__CCDS2340.1

<400>  722
augaaguccc agggccagca cugguacagc agcuccgaca agaacugcaa ggugagcuuc       60

cgcgagaagc ugcucaucau cgacuccaac cugggggucc aggacgugga gaaccugaag      120

uuccucugca ucggccuggu gcccaacaag aagcuggaga aguccagcag cgccuccgac      180

gucuucgagc accuccuggc cgaggaccug cucagcgagg aggacccguu cuuccuggcg      240

gagcugcucu acaucauccg gcagaagaag cugcugcagc accucaacug caccaaggag      300

gagguggagc gccugcugcc cacccggcag cgcguguccc ucuuccggaa ccugcuguac      360

gagcucagcg aggggaucga cuccgagaac cugaaggaca ugaucuuccu gcucaaggac      420

agccugccca agacggagau gaccucccug agcuuccucg ccuuccugga gaagcagggc      480

aagaucgacg aggacaaccu gaccugccuc gaggaccugu gcaagaccgu cgugcccaag      540

cugcuccgca acaucgagaa guacaagcgg gagaaggcca uccagaucgu gacgccgccc      600

gucgacaagg aggccgaguc cuaccagggg gaggaggagc uggugagcca gaccgacgug      660

aagaccuucc uggaggcccu cccccaggag uccuggcaga acaagcacgc gggcagcaac      720

ggcaaccgcg ccaccaacgg ggcccccagc cuggucuccc ggggcaugca gggggccagc      780

gcgaacacgc ugaacuccga gaccagcacc aagcgcgccg ccguguaccg gaugaaccgc      840

aaccaccggg gccucugcgu gaucgucaac aaccacuccu ucaccagccu gaaggaccgc      900

caggggacgc acaaggacgc cgagauccug ucccacgugu uccaguggcu cggcuucacc      960

gugcacaucc acaacaacgu caccaaggug gagauggaga uggugcugca gaagcagaag     1020

ugcaacccgg cccacgcgga cggcgacugc uucgucuucu gcauccugac ccacgggcgg     1080

uucggcgccg uguacagcuc cgacgaggcc cucaucccca uccgcgagau caugagccac     1140

uucacggccc ugcagugccc ccggcuggcc gagaagccca agcuguucuu cauccaggcg     1200

ugccaggggg aggagaucca gccguccgug agcaucgagg ccgacgcccu caaccccgag     1260

caggccccca ccucccugca ggacagcauc cccgccgagg cggacuuccu gcucggccug     1320

gccaccgucc cgggcuacgu guccuuccgc cacgucgagg aggggagcug guacauccag     1380

ucccugugca accaccucaa gaagcuggug ccccggcacg aggacauccu gagcauccuc     1440

accgccguga acgacgacgu cucccgccgg guggacaagc agggcacgaa gaagcagaug     1500

ccccagcccg ccuucacccu gcgcaagaag cugguguucc cggucccccu cgacgcccug     1560

agccuguga                                                             1569


<210>  723
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CASPA__Homo_sapiens__CCDS2340.1

<400>  723
augaaguccc agggccagca cugguacucc uccuccgaca agaacugcaa ggucuccuuc       60

cgcgagaagc uccucaucau cgacuccaac cucggcgucc aggacgucga gaaccucaag      120

uuccucugca ucggccucgu ccccaacaag aagcucgaga aguccuccuc cgccuccgac      180

gucuucgagc accuccucgc cgaggaccuc cucuccgagg aggaccccuu cuuccucgcc      240

gagcuccucu acaucauccg ccagaagaag cuccuccagc accucaacug caccaaggag      300

gaggucgagc gccuccuccc cacccgccag cgcgucuccc ucuuccgcaa ccuccucuac      360

gagcucuccg agggcaucga cuccgagaac cucaaggaca ugaucuuccu ccucaaggac      420

ucccucccca agaccgagau gaccucccuc uccuuccucg ccuuccucga gaagcagggc      480

aagaucgacg aggacaaccu caccugccuc gaggaccucu gcaagaccgu cguccccaag      540

cuccuccgca acaucgagaa guacaagcgc gagaaggcca uccagaucgu cacccccccc      600

gucgacaagg aggccgaguc cuaccagggc gaggaggagc ucgucuccca gaccgacguc      660

aagaccuucc ucgaggcccu cccccaggag uccuggcaga acaagcacgc cggcuccaac      720

ggcaaccgcg ccaccaacgg cgcccccucc cucgucuccc gcggcaugca gggcgccucc      780

gccaacaccc ucaacuccga gaccuccacc aagcgcgccg ccgucuaccg caugaaccgc      840

aaccaccgcg gccucugcgu caucgucaac aaccacuccu ucaccucccu caaggaccgc      900

cagggcaccc acaaggacgc cgagauccuc ucccacgucu uccaguggcu cggcuucacc      960

guccacaucc acaacaacgu caccaagguc gagauggaga ugguccucca gaagcagaag     1020

ugcaaccccg cccacgccga cggcgacugc uucgucuucu gcauccucac ccacggccgc     1080

uucggcgccg ucuacuccuc cgacgaggcc cucaucccca uccgcgagau caugucccac     1140

uucaccgccc uccagugccc ccgccucgcc gagaagccca agcucuucuu cauccaggcc     1200

ugccagggcg aggagaucca gcccuccguc uccaucgagg ccgacgcccu caaccccgag     1260

caggccccca ccucccucca ggacuccauc cccgccgagg ccgacuuccu ccucggccuc     1320

gccaccgucc ccggcuacgu cuccuuccgc cacgucgagg agggcuccug guacauccag     1380

ucccucugca accaccucaa gaagcucguc ccccgccacg aggacauccu cuccauccuc     1440

accgccguca acgacgacgu cucccgccgc gucgacaagc agggcaccaa gaagcagaug     1500

ccccagcccg ccuucacccu ccgcaagaag cucgucuucc ccgucccccu cgacgcccuc     1560

ucccucuga                                                             1569


<210>  724
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CASPA__Homo_sapiens__CCDS2340.1

<400>  724
augaaaagcc agggccaaca cugguacucc ucuucagaca agaacugcaa ggugaguuuc       60

agagagaaac ugcucaucau ugauagcaau cuuggggucc aggacguuga aaaccugaag      120

uuuuugugua uaggauuagu gcccaauaaa aagcuggaga aguccucuuc ggccucagau      180

guauucgaac aucuacucgc ugaggaccug cuuagcgaag aggauccauu uuuccuggca      240

gaguugcucu auaucauuag gcagaaaaag cugcugcagc accucaacug caccaaagaa      300

gagguggaac gguuacugcc uacacgccaa cgagucaguc uuuuucguaa uuugcuguac      360

gagcuauccg aggguaucga cucugaaaac cucaaggaua ugauuuuccu gcuuaaagac      420

agccugccga agacugagau gacguccuug ucauuucucg ccuuccugga aaagcagggc      480

aaaaucgaug aggacaauuu aaccugucug gaagaucucu gcaagacagu gguucccaaa      540

cuucugagaa acauagagaa guauaaaagg gagaaggcga uccagauugu gacuccucca      600

gucgacaaag aagcugagag uuaccagggg gaagaggaau uggugagcca aaccgaugua      660

aagacauuuc uagaggcccu gccccaggag ucuuggcaga auaagcaugc aggauccaac      720

ggcaaucggg ccaccaacgg ugcuccuuca cucguuagcc gcgggaugca gggagcaagu      780

gccaauacuc ugaacucuga aacauccacc aaaagagcug ccguguauag gaugaaucgg      840

aaccaccgcg gccuuugugu caucgugaac aaucauagcu ucacgucgcu gaaggaccga      900

caaggcacuc acaaagacgc ggagauuuug ucucacgugu uucaguggcu cggguucacc      960

guccauaucc acaacaaugu uacaaaggug gaaauggaga ugguacugca gaaacaaaag     1020

ugcaacccag cacaugccga uggagacugu uuuguguucu gcauauuaac ucacgguaga     1080

uucggcgcug ucuacuccuc agaugaagcc cugauuccca ucagggagau uaugagucac     1140

uuuaccgcac uacagugucc ucggcucgcu gagaagccaa aacuguucuu uauccaggcc     1200

ugccaggggg aagagaucca accgagcgug uccauugaag cggacgcccu uaaucccgag     1260

caggcaccua caucuuugca ggauagcaua ccagcugagg ccgacuuccu gcucggacug     1320

gcuaccguuc ccggcuaugu gucauuucgu caugucgaag aggguaguug guacauccag     1380

ucccuuugua accaccugaa gaaauuggug ccucgccaug aagauauucu cagcauccug     1440

acggccguaa augacgaugu uucuagaagg guggacaagc aagggacuaa aaagcagaug     1500

ccacagcccg cauucacauu acggaagaaa cuggucuuuc cggugccucu agaugcccuc     1560

ucacuguga                                                             1569


<210>  725
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CASPA__Homo_sapiens__CCDS2340.1

<400>  725
augaagagcc agggccagca cugguacagc agcagcgaca agaacugcaa ggugagcuuc       60

agagagaagc ugcugaucau cgacagcaac cugggcgugc aggacgugga gaaccugaag      120

uuccugugca ucggccuggu gcccaacaag aagcuggaga agagcagcag cgccagcgac      180

guguucgagc accugcuggc cgaggaccug cugagcgagg aggaccccuu cuuccuggcc      240

gagcugcugu acaucaucag acagaagaag cugcugcagc accugaacug caccaaggag      300

gagguggaga gacugcugcc caccagacag agagugagcc uguucagaaa ccugcuguac      360

gagcugagcg agggcaucga cagcgagaac cugaaggaca ugaucuuccu gcugaaggac      420

agccugccca agaccgagau gaccagccug agcuuccugg ccuuccugga gaagcagggc      480

aagaucgacg aggacaaccu gaccugccug gaggaccugu gcaagaccgu ggugcccaag      540

cugcugagaa acaucgagaa guacaagaga gagaaggcca uccagaucgu gacccccccc      600

guggacaagg aggccgagag cuaccagggc gaggaggagc uggugagcca gaccgacgug      660

aagaccuucc uggaggcccu gccccaggag agcuggcaga acaagcacgc cggcagcaac      720

ggcaacagag ccaccaacgg cgcccccagc cuggugagca gaggcaugca gggcgccagc      780

gccaacaccc ugaacagcga gaccagcacc aagagagccg ccguguacag aaugaacaga      840

aaccacagag gccugugcgu gaucgugaac aaccacagcu ucaccagccu gaaggacaga      900

cagggcaccc acaaggacgc cgagauccug agccacgugu uccaguggcu gggcuucacc      960

gugcacaucc acaacaacgu gaccaaggug gagauggaga uggugcugca gaagcagaag     1020

ugcaaccccg cccacgccga cggcgacugc uucguguucu gcauccugac ccacggcaga     1080

uucggcgccg uguacagcag cgacgaggcc cugaucccca ucagagagau caugagccac     1140

uucaccgccc ugcagugccc cagacuggcc gagaagccca agcuguucuu cauccaggcc     1200

ugccagggcg aggagaucca gcccagcgug agcaucgagg ccgacgcccu gaaccccgag     1260

caggccccca ccagccugca ggacagcauc cccgccgagg ccgacuuccu gcugggccug     1320

gccaccgugc ccggcuacgu gagcuucaga cacguggagg agggcagcug guacauccag     1380

agccugugca accaccugaa gaagcuggug cccagacacg aggacauccu gagcauccug     1440

accgccguga acgacgacgu gagcagaaga guggacaagc agggcaccaa gaagcagaug     1500

ccccagcccg ccuucacccu gagaaagaag cugguguucc ccgugccccu ggacgcccug     1560

agccuguga                                                             1569


<210>  726
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CASPA__Homo_sapiens__CCDS2340.1

<400>  726
augaaaagcc agggccaaca cugguacucc ucuagcgaca aaaacugcaa gguguccuuc       60

agagagaaac ugcucaucau ugauucuaau cugggggucc aggacguuga aaaccuuaag      120

uuucugugua ucggacucgu gcccaauaaa aagcuggaaa agagcuccuc ugccagcgau      180

guguucgagc aucuucuggc ugaggaccuc cuguccgaag aggauccguu uuuccuggcc      240

gagcuccugu auauuauccg gcagaaaaag cugcuucagc accucaacug caccaaagaa      300

gaggucgaac gccugcuucc uacaagacaa cgggugagcc uguuucgcaa ucuccuguac      360

gagcugucug agggcauuga cuccgaaaac cucaaggaua ugaucuuccu gcuuaaagac      420

agccugccca agacggagau gaccucucuc uccuuucugg cguuccuuga aaagcagggg      480

aaaaucgaug aggacaaucu gacaugucuc gaagaucugu gcaagaccgu ugugccuaaa      540

cugcucagaa acauugagaa guauaaacgg gagaaggcua uccagauugu cacacccccu      600

guggacaaag aagccgagag cuaccaggga gaagaggaac ugguuucuca aaccgaugug      660

aagacauuuc uugaggcccu gccccaggag uccuggcaga auaagcaugc uggcagcaac      720

gggaaucgcg ccaccaacgg agcuccuucc cucgucucua gaggcaugca gggcgccagc      780

gcgaauacgc ugaacuccga aaccagcaca aaacgggccg cuguguaucg caugaauaga      840

aaccaccggg ggcuuugugu gaucgucaac aaucauucuu ucaccucccu gaaggaccgc      900

caaggaacac acaaagacgc cgagauucuc agccacguuu uucaguggcu gggcuucacc      960

gugcauaucc acaacaaugu gacgaagguc gaaauggaga uggugcugca gaaacaaaag     1020

ugcaacccgg cucaugccga uggggacugu uuuguuuucu gcauucucac acacggaaga     1080

uucggcgcgg uguacucuag cgaugaagcc cugaucccca uccgggagau uaugucccac     1140

uuuaccgccc uucagugucc ucgccuggcu gagaagccca aacucuucuu uauccaggcu     1200

ugccaggggg aagagauuca accuucuguc agcaucgaag ccgacgcccu gaaucccgag     1260

caggcuccga caucccugca ggauagcauu ccugcggagg ccgacuuccu ucucggacug     1320

gcuaccgugc ccggcuaugu uucuuuuaga cauguggaag agggcuccug guacauccag     1380

agccugugua accaccucaa gaaacugguc ccucggcaug aagauauccu uucuauucug     1440

accgccguga augacgaugu cuccagacgc guggacaagc aagggacaaa gaagcagaug     1500

ccccagcccg ccuucacgcu ccggaagaaa cugguuuuuc cugugccgcu ggaugcucuu     1560

agccucuga                                                             1569


<210>  727
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cathepsin_B__Homo_sapiens__A0A024R374

<400>  727

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  728
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cathepsin_B__Homo_sapiens__EAW65632

<400>  728
auguggcagc ucugggccuc ccucugcugc cugcuggugu uggccaaugc ccggagcagg       60

cccucuuucc auccccuguc ggaugagcug gucaacuaug ucaacaaacg gaauaccacg      120

uggcaggccg ggcacaacuu cuacaacgug gacaugagcu acuugaagag gcuauguggu      180

accuuccugg gugggcccaa gccaccccag agaguuaugu uuaccgagga ccugaagcug      240

ccugcaagcu ucgaugcacg ggaacaaugg ccacaguguc ccaccaucaa agagaucaga      300

gaccagggcu ccuguggcuc cugcugggcc uucggggcug uggaagccau cucugaccgg      360

aucugcaucc acaccaaugc gcacgucagc guggaggugu cggcggagga ccugcucacc      420

ugcuguggca gcaugugugg ggacggcugu aaugguggcu auccugcuga agcuuggaac      480

uucuggacaa gaaaaggccu gguuucuggu ggccucuaug aaucccaugu agggugcaga      540

ccguacucca ucccucccug ugagcaccac gucaacggcu cccggccccc augcacgggg      600

gagggagaua cccccaagug uagcaagauc ugugagccug gcuacagccc gaccuacaaa      660

caggacaagc acuacggaua caauuccuac agcgucucca auagcgagaa ggacaucaug      720

gccgagaucu acaaaaacgg ccccguggag ggagcuuucu cuguguauuc ggacuuccug      780

cucuacaagu caggagugua ccaacacguc accggagaga ugaugggugg ccaugccauc      840

cgcauccugg gcuggggagu ggagaauggc acacccuacu ggcugguugc caacuccugg      900

aacacugacu ggggugacaa uggcuucuuu aaaauacuca gaggacagga ucacugugga      960

aucgaaucag aagugguggc uggaauucca cgcaccgauc aguacuggga aaagaucuaa     1020


<210>  729
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cathepsin_B__Homo_sapiens__EAW65632

<400>  729
auguggcagc ugugggccag ccucugcugc cugcuggugc ucgccaacgc gcgcucccgg       60

cccagcuucc acccgcuguc cgacgagcug gucaacuacg ugaacaagcg caacaccacc      120

uggcaggccg gccacaacuu cuacaacgug gacaugagcu accucaagcg gcugugcggg      180

acguuccugg gcgggcccaa gccgccccag cgcgucaugu ucaccgagga ccucaagcug      240

cccgccuccu ucgacgcccg ggagcagugg ccccagugcc ccaccaucaa ggagauccgc      300

gaccagggca gcugcggguc cugcugggcc uucggcgcgg uggaggccau cagcgaccgg      360

aucugcaucc acaccaacgc ccacgugucc gucgagguga gcgccgagga ccugcucacg      420

ugcugcggcu ccaugugcgg ggacggcugc aacgggggcu accccgcgga ggccuggaac      480

uucuggaccc gcaaggggcu ggugagcggc ggccuguacg agucccacgu cgggugccgg      540

ccguacagca ucccgcccug cgagcaccac gugaacggcu cccgcccgcc cugcaccggg      600

gagggcgaca cccccaagug cagcaagauc ugcgagcccg gcuacucccc cacguacaag      660

caggacaagc acuacgggua caacagcuac uccgugagca acagcgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccgucgag ggggccuucu ccguguacag cgacuuccuc      780

cuguacaagu ccggcgugua ccagcacguc accggggaga ugaugggcgg ccacgccauc      840

cggauccugg gguggggcgu ggagaacggg acccccuacu ggcucguggc gaacagcugg      900

aacaccgacu ggggcgacaa cggguucuuc aagauccugc gcggccagga ccacugcggc      960

aucgaguccg aggucguggc cgggaucccc cggacggacc aguacuggga gaagaucuga     1020


<210>  730
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cathepsin_B__Homo_sapiens__EAW65632

<400>  730
auguggcagc ucugggccuc ccucugcugc cuccucgucc ucgccaacgc ccgcucccgc       60

cccuccuucc acccccucuc cgacgagcuc gucaacuacg ucaacaagcg caacaccacc      120

uggcaggccg gccacaacuu cuacaacguc gacauguccu accucaagcg ccucugcggc      180

accuuccucg gcggccccaa gcccccccag cgcgucaugu ucaccgagga ccucaagcuc      240

cccgccuccu ucgacgcccg cgagcagugg ccccagugcc ccaccaucaa ggagauccgc      300

gaccagggcu ccugcggcuc cugcugggcc uucggcgccg ucgaggccau cuccgaccgc      360

aucugcaucc acaccaacgc ccacgucucc gucgaggucu ccgccgagga ccuccucacc      420

ugcugcggcu ccaugugcgg cgacggcugc aacggcggcu accccgccga ggccuggaac      480

uucuggaccc gcaagggccu cgucuccggc ggccucuacg agucccacgu cggcugccgc      540

cccuacucca ucccccccug cgagcaccac gucaacggcu cccgcccccc cugcaccggc      600

gagggcgaca cccccaagug cuccaagauc ugcgagcccg gcuacucccc caccuacaag      660

caggacaagc acuacggcua caacuccuac uccgucucca acuccgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccgucgag ggcgccuucu ccgucuacuc cgacuuccuc      780

cucuacaagu ccggcgucua ccagcacguc accggcgaga ugaugggcgg ccacgccauc      840

cgcauccucg gcuggggcgu cgagaacggc acccccuacu ggcucgucgc caacuccugg      900

aacaccgacu ggggcgacaa cggcuucuuc aagauccucc gcggccagga ccacugcggc      960

aucgaguccg aggucgucgc cggcaucccc cgcaccgacc aguacuggga gaagaucuga     1020


<210>  731
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cathepsin_B__Homo_sapiens__EAW65632

<400>  731
auguggcagc ugugggccag ccucugcugu cuucuggugu uggcuaacgc aagauccagg       60

cccucuuucc acccuuuauc agacgagcug gucaauuacg uuaacaagcg gaauaccaca      120

uggcaagccg gccauaacuu uuauaaugug gauaugaguu accuaaaacg ccucugcggg      180

acuuuccugg gagguccaaa gccgccccag cgaguaaugu uuacggaaga ccuuaaacug      240

ccugcgagcu ucgaugcucg ugagcagugg ccacaguguc ccaccaucaa ggaaauuaga      300

gaccaaggcu ccugcggguc uuguugggcc uuuggagcag uggaggccau aucggauagg      360

aucugcauuc acacaaacgc ucaugucuca guggaaguua gcgcagagga cuugcucacu      420

uguugcggca guaugugugg ugaugggugc aauggaggcu auccugccga ggcuuggaac      480

uucuggaccc ggaaaggccu gguguccggg ggacuguacg aaucucacgu cgguugucgc      540

ccauauagca uucccccuug cgagcaucac gugaauggcu ccagaccacc gugcacaggg      600

gaaggagaca cccccaagug uucaaagauc ugcgagccug gcuacagucc aacuuauaaa      660

caggauaagc acuacgguua caacagcuau ucuguaucca auucagagaa agacaucaug      720

gccgaaauau acaagaacgg gcccguugag ggagcguuua gcguguauag ugauuuccuc      780

uuauacaaau cuggcgucua ucagcaugug acaggcgaaa ugaugggagg gcacgcaauc      840

aggauucugg guuggggcgu ggagaauggg accccuuacu ggcuugucgc caacuccugg      900

aauacggacu ggggagauaa cggcuuuuuc aagaucuugc ggggucagga ccauuguggg      960

auugaaagcg agguuguggc uggcauccca cgcacugacc aauauuggga gaagauauga     1020


<210>  732
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cathepsin_B__Homo_sapiens__EAW65632

<400>  732
auguggcagc ugugggccag ccugugcugc cugcuggugc uggccaacgc cagaagcaga       60

cccagcuucc acccccugag cgacgagcug gugaacuacg ugaacaagag aaacaccacc      120

uggcaggccg gccacaacuu cuacaacgug gacaugagcu accugaagag acugugcggc      180

accuuccugg gcggccccaa gcccccccag agagugaugu ucaccgagga ccugaagcug      240

cccgccagcu ucgacgccag agagcagugg ccccagugcc ccaccaucaa ggagaucaga      300

gaccagggca gcugcggcag cugcugggcc uucggcgccg uggaggccau cagcgacaga      360

aucugcaucc acaccaacgc ccacgugagc guggagguga gcgccgagga ccugcugacc      420

ugcugcggca gcaugugcgg cgacggcugc aacggcggcu accccgccga ggccuggaac      480

uucuggacca gaaagggccu ggugagcggc ggccuguacg agagccacgu gggcugcaga      540

cccuacagca ucccccccug cgagcaccac gugaacggca gcagaccccc cugcaccggc      600

gagggcgaca cccccaagug cagcaagauc ugcgagcccg gcuacagccc caccuacaag      660

caggacaagc acuacggcua caacagcuac agcgugagca acagcgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccguggag ggcgccuuca gcguguacag cgacuuccug      780

cuguacaaga gcggcgugua ccagcacgug accggcgaga ugaugggcgg ccacgccauc      840

agaauccugg gcuggggcgu ggagaacggc acccccuacu ggcugguggc caacagcugg      900

aacaccgacu ggggcgacaa cggcuucuuc aagauccuga gaggccagga ccacugcggc      960

aucgagagcg aggugguggc cggcaucccc agaaccgacc aguacuggga gaagaucuga     1020


<210>  733
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cathepsin_B__Homo_sapiens__EAW65632

<400>  733
auguggcagc ugugggccag ccucugcugu cugcuugugc uggcuaacgc cagaucccgg       60

cccucuuucc acccucucag cgacgagcug gucaauuacg uuaacaagcg caauaccaca      120

uggcaagcgg gccauaacuu uuauaaugug gauauguccu accuuaaaag acugugcggg      180

acguuccucg gaggcccgaa gcccccucag cgggugaugu uuaccgaaga ccugaaacug      240

cccgcuucuu ucgaugcccg cgagcagugg ccucaguguc ccacaaucaa ggaaauuaga      300

gaccaaggga gcugcggauc cuguugggcc uuuggcgcug ucgaggccau cucugaucgg      360

auuugcaucc acaccaacgc ucaugugagc guugaagugu ccgccgagga ccuccugaca      420

uguugcggga gcaugugugg agauggcugc aauggcgggu auccugcgga ggccuggaac      480

uucuggaccc gcaaaggacu ugucucuggc gggcuguacg aaucccacgu gggauguaga      540

ccguauagca uucccccuug cgagcaucac guuaauggcu cucggccccc uugcacaggg      600

gaaggagaca cccccaagug uuccaagauc ugcgagccgg gcuacagccc uacguauaaa      660

caggauaagc acuacggcua caacucuuau uccgugagca auuccgagaa agacaucaug      720

gcugaaauuu acaagaacgg gcccgucgag ggagccuuuu cuguguauag cgauuuccuc      780

cuguacaaau ccggcgugua ucagcauguc accggggaaa ugaugggagg ccacgcuauc      840

cgcauucuug gguggggagu ugagaauggc acaccuuacu ggcugguggc caacagcugg      900

aauaccgacu ggggcgauaa cggguuuuuc aagauccuca gaggacagga ccauuguggc      960

auugaaucug agguggucgc ggggaucccc cggacagacc aauauuggga gaagauuuga     1020


<210>  734
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cathepsin_B__Homo_sapiens__P07858

<400>  734

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  735
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cathepsin_B__Homo_sapiens__AAC37547

<400>  735
auguggcagc ucugggccuc ccucugcugc cugcuggugu uggccaaugc ccggagcagg       60

cccucuuucc auccccuguc ggaugagcug gucaacuaug ucaacaaacg gaauaccacg      120

uggcaggccg ggcacaacuu cuacaacgug gacaugagcu acuugaagag gcuauguggu      180

accuuccugg gugggcccaa gccaccccag agaguuaugu uuaccgagga ccugaagcug      240

ccugcaagcu ucgaugcacg ggaacaaugg ccacaguguc ccaccaucaa agagaucaga      300

gaccagggcu ccuguggcuc cugcugggcc uucggggcug uggaagccau cucugaccgg      360

aucugcaucc acaccaaugc gcacgucagc guggaggugu cggcggagga ccugcucaca      420

ugcuguggca gcaugugugg ggacggcugu aaugguggcu auccugcuga agcuuggaac      480

uucuggacaa gaaaaggccu gguuucuggu ggccucuaug aaucccaugu agggugcaga      540

ccguacucca ucccucccug ugagcaccac gucaacggcu cccggccccc augcacgggg      600

gagggagaua cccccaagug uagcaagauc ugugagccug gcuacagccc gaccuacaaa      660

caggacaagc acuacggaua caauuccuac agcgucucca auagcgagaa ggacaucaug      720

gccgagaucu acaaaaacgg ccccguggag ggagcuuucu cuguguauuc ggacuuccug      780

cucuacaagu caggagugua ccaacacguc accggagaga ugaugggugg ccaugccauc      840

cgcauccugg gcuggggagu ggagaauggc acacccuacu ggcugguugc caacuccugg      900

aacacugacu ggggugacaa uggcuucuuu aaaauacuca gaggacagga ucacugugga      960

aucgaaucag aagugguggc uggaauucca cgcaccgauc aguacuggga aaagaucuaa     1020


<210>  736
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cathepsin_B__Homo_sapiens__AAC37547

<400>  736
auguggcagc ugugggccag ccucugcugc cugcuggugc ucgccaacgc gcgcucccgg       60

cccagcuucc acccgcuguc cgacgagcug gucaacuacg ugaacaagcg caacaccacc      120

uggcaggccg gccacaacuu cuacaacgug gacaugagcu accucaagcg gcugugcggg      180

acguuccugg gcgggcccaa gccgccccag cgcgucaugu ucaccgagga ccucaagcug      240

cccgccuccu ucgacgcccg ggagcagugg ccccagugcc ccaccaucaa ggagauccgc      300

gaccagggca gcugcggguc cugcugggcc uucggcgcgg uggaggccau cagcgaccgg      360

aucugcaucc acaccaacgc ccacgugucc gucgagguga gcgccgagga ccugcucacg      420

ugcugcggcu ccaugugcgg ggacggcugc aacgggggcu accccgcgga ggccuggaac      480

uucuggaccc gcaaggggcu ggugagcggc ggccuguacg agucccacgu cgggugccgg      540

ccguacagca ucccgcccug cgagcaccac gugaacggcu cccgcccgcc cugcaccggg      600

gagggcgaca cccccaagug cagcaagauc ugcgagcccg gcuacucccc cacguacaag      660

caggacaagc acuacgggua caacagcuac uccgugagca acagcgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccgucgag ggggccuucu ccguguacag cgacuuccuc      780

cuguacaagu ccggcgugua ccagcacguc accggggaga ugaugggcgg ccacgccauc      840

cggauccugg gguggggcgu ggagaacggg acccccuacu ggcucguggc gaacagcugg      900

aacaccgacu ggggcgacaa cggguucuuc aagauccugc gcggccagga ccacugcggc      960

aucgaguccg aggucguggc cgggaucccc cggacggacc aguacuggga gaagaucuga     1020


<210>  737
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cathepsin_B__Homo_sapiens__AAC37547

<400>  737
auguggcagc ucugggccuc ccucugcugc cuccucgucc ucgccaacgc ccgcucccgc       60

cccuccuucc acccccucuc cgacgagcuc gucaacuacg ucaacaagcg caacaccacc      120

uggcaggccg gccacaacuu cuacaacguc gacauguccu accucaagcg ccucugcggc      180

accuuccucg gcggccccaa gcccccccag cgcgucaugu ucaccgagga ccucaagcuc      240

cccgccuccu ucgacgcccg cgagcagugg ccccagugcc ccaccaucaa ggagauccgc      300

gaccagggcu ccugcggcuc cugcugggcc uucggcgccg ucgaggccau cuccgaccgc      360

aucugcaucc acaccaacgc ccacgucucc gucgaggucu ccgccgagga ccuccucacc      420

ugcugcggcu ccaugugcgg cgacggcugc aacggcggcu accccgccga ggccuggaac      480

uucuggaccc gcaagggccu cgucuccggc ggccucuacg agucccacgu cggcugccgc      540

cccuacucca ucccccccug cgagcaccac gucaacggcu cccgcccccc cugcaccggc      600

gagggcgaca cccccaagug cuccaagauc ugcgagcccg gcuacucccc caccuacaag      660

caggacaagc acuacggcua caacuccuac uccgucucca acuccgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccgucgag ggcgccuucu ccgucuacuc cgacuuccuc      780

cucuacaagu ccggcgucua ccagcacguc accggcgaga ugaugggcgg ccacgccauc      840

cgcauccucg gcuggggcgu cgagaacggc acccccuacu ggcucgucgc caacuccugg      900

aacaccgacu ggggcgacaa cggcuucuuc aagauccucc gcggccagga ccacugcggc      960

aucgaguccg aggucgucgc cggcaucccc cgcaccgacc aguacuggga gaagaucuga     1020


<210>  738
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cathepsin_B__Homo_sapiens__AAC37547

<400>  738
auguggcagc ugugggccag ccucugcugu cuucuggugu uggcuaacgc aagauccagg       60

cccucuuucc acccuuuauc agacgagcug gucaauuacg uuaacaagcg gaauaccaca      120

uggcaagccg gccauaacuu uuauaaugug gauaugaguu accuaaaacg ccucugcggg      180

acuuuccugg gagguccaaa gccgccccag cgaguaaugu uuacggaaga ccuuaaacug      240

ccugcgagcu ucgaugcucg ugagcagugg ccacaguguc ccaccaucaa ggaaauuaga      300

gaccaaggcu ccugcggguc uuguugggcc uuuggagcag uggaggccau aucggauagg      360

aucugcauuc acacaaacgc ucaugucuca guggaaguua gcgcagagga cuugcucacu      420

uguugcggca guaugugugg ugaugggugc aauggaggcu auccugccga ggcuuggaac      480

uucuggaccc ggaaaggccu gguguccggg ggacuguacg aaucucacgu cgguugucgc      540

ccauauagca uucccccuug cgagcaucac gugaauggcu ccagaccacc gugcacaggg      600

gaaggagaca cccccaagug uucaaagauc ugcgagccug gcuacagucc aacuuauaaa      660

caggauaagc acuacgguua caacagcuau ucuguaucca auucagagaa agacaucaug      720

gccgaaauau acaagaacgg gcccguugag ggagcguuua gcguguauag ugauuuccuc      780

uuauacaaau cuggcgucua ucagcaugug acaggcgaaa ugaugggagg gcacgcaauc      840

aggauucugg guuggggcgu ggagaauggg accccuuacu ggcuugucgc caacuccugg      900

aauacggacu ggggagauaa cggcuuuuuc aagaucuugc ggggucagga ccauuguggg      960

auugaaagcg agguuguggc uggcauccca cgcacugacc aauauuggga gaagauauga     1020


<210>  739
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cathepsin_B__Homo_sapiens__AAC37547

<400>  739
auguggcagc ugugggccag ccugugcugc cugcuggugc uggccaacgc cagaagcaga       60

cccagcuucc acccccugag cgacgagcug gugaacuacg ugaacaagag aaacaccacc      120

uggcaggccg gccacaacuu cuacaacgug gacaugagcu accugaagag acugugcggc      180

accuuccugg gcggccccaa gcccccccag agagugaugu ucaccgagga ccugaagcug      240

cccgccagcu ucgacgccag agagcagugg ccccagugcc ccaccaucaa ggagaucaga      300

gaccagggca gcugcggcag cugcugggcc uucggcgccg uggaggccau cagcgacaga      360

aucugcaucc acaccaacgc ccacgugagc guggagguga gcgccgagga ccugcugacc      420

ugcugcggca gcaugugcgg cgacggcugc aacggcggcu accccgccga ggccuggaac      480

uucuggacca gaaagggccu ggugagcggc ggccuguacg agagccacgu gggcugcaga      540

cccuacagca ucccccccug cgagcaccac gugaacggca gcagaccccc cugcaccggc      600

gagggcgaca cccccaagug cagcaagauc ugcgagcccg gcuacagccc caccuacaag      660

caggacaagc acuacggcua caacagcuac agcgugagca acagcgagaa ggacaucaug      720

gccgagaucu acaagaacgg ccccguggag ggcgccuuca gcguguacag cgacuuccug      780

cuguacaaga gcggcgugua ccagcacgug accggcgaga ugaugggcgg ccacgccauc      840

agaauccugg gcuggggcgu ggagaacggc acccccuacu ggcugguggc caacagcugg      900

aacaccgacu ggggcgacaa cggcuucuuc aagauccuga gaggccagga ccacugcggc      960

aucgagagcg aggugguggc cggcaucccc agaaccgacc aguacuggga gaagaucuga     1020


<210>  740
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cathepsin_B__Homo_sapiens__AAC37547

<400>  740
auguggcagc ugugggccag ccucugcugu cugcuugugc uggcuaacgc cagaucccgg       60

cccucuuucc acccucucag cgacgagcug gucaauuacg uuaacaagcg caauaccaca      120

uggcaagcgg gccauaacuu uuauaaugug gauauguccu accuuaaaag acugugcggg      180

acguuccucg gaggcccgaa gcccccucag cgggugaugu uuaccgaaga ccugaaacug      240

cccgcuucuu ucgaugcccg cgagcagugg ccucaguguc ccacaaucaa ggaaauuaga      300

gaccaaggga gcugcggauc cuguugggcc uuuggcgcug ucgaggccau cucugaucgg      360

auuugcaucc acaccaacgc ucaugugagc guugaagugu ccgccgagga ccuccugaca      420

uguugcggga gcaugugugg agauggcugc aauggcgggu auccugcgga ggccuggaac      480

uucuggaccc gcaaaggacu ugucucuggc gggcuguacg aaucccacgu gggauguaga      540

ccguauagca uucccccuug cgagcaucac guuaauggcu cucggccccc uugcacaggg      600

gaaggagaca cccccaagug uuccaagauc ugcgagccgg gcuacagccc uacguauaaa      660

caggauaagc acuacggcua caacucuuau uccgugagca auuccgagaa agacaucaug      720

gcugaaauuu acaagaacgg gcccgucgag ggagccuuuu cuguguauag cgauuuccuc      780

cuguacaaau ccggcgugua ucagcauguc accggggaaa ugaugggagg ccacgcuauc      840

cgcauucuug gguggggagu ugagaauggc acaccuuacu ggcugguggc caacagcugg      900

aauaccgacu ggggcgauaa cggguuuuuc aagauccuca gaggacagga ccauuguggc      960

auugaaucug agguggucgc ggggaucccc cggacagacc aauauuggga gaagauuuga     1020


<210>  741
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__A0A024R276

<400>  741

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  742
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__EAW62731

<400>  742
augaauccua cacucauccu ugcugccuuu ugccugggaa uugccucagc uacucuaaca       60

uuugaucaca guuuagaggc acaguggacc aaguggaagg cgaugcacaa cagauuauac      120

ggcaugaaug aagaaggaug gaggagagca gugugggaga agaacaugaa gaugauugaa      180

cugcacaauc aggaauacag ggaagggaaa cacagcuuca caauggccau gaacgccuuu      240

ggagacauga ccagugaaga auucaggcag gugaugaaug gcuuucaaaa ccguaagccc      300

aggaagggga aaguguucca ggaaccucug uuuuaugagg cccccagauc uguggauugg      360

agagagaaag gcuacgugac uccugugaag aaucaggguc agugugguuc uuguugggcu      420

uuuagugcua cuggugcucu ugaaggacag auguuccgga aaacugggag gcuuaucuca      480

cugagugagc agaaucuggu agacugcucu gggccucaag gcaaugaagg cugcaauggu      540

ggccuaaugg auuaugcuuu ccaguauguu caggauaaug gaggccugga cucugaggaa      600

uccuauccau augaggcaac agaagaaucc uguaaguaca aucccaagua uucuguugcu      660

aaugacaccg gcuuugugga caucccuaag caggagaagg cccugaugaa ggcaguugca      720

acuguggggc ccauuucugu ugcuauugau gcaggucaug aguccuuccu guucuauaaa      780

gaaggcauuu auuuugagcc agacuguagc agugaagaca uggaucaugg ugugcuggug      840

guuggcuacg gauuugaaag cacagaauca gauaacaaua aauauuggcu ggugaagaac      900

agcuggggug aagaaugggg cauggguggc uacguaaaga uggccaaaga ccggagaaac      960

cauuguggaa uugccucagc agccagcuac cccacugugu ga                        1002


<210>  743
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cathepsin_L__Homo_sapiens__EAW62731

<400>  743
augaacccca cccugauccu cgccgccuuc ugccugggca ucgcgagcgc cacccugacg       60

uucgaccacu cccucgaggc ccaguggacc aaguggaagg ccaugcacaa ccgccuguac      120

gggaugaacg aggagggcug gcggcgcgcc gugugggaga agaacaugaa gaugaucgag      180

cugcacaacc aggaguaccg ggaggggaag cacagcuuca ccauggcgau gaacgccuuc      240

ggcgacauga ccuccgagga guuccgccag gucaugaacg gguuccagaa ccggaagccg      300

cgcaagggca agguguucca ggagccccuc uucuacgagg cgccccggag cguggacugg      360

cgcgagaagg gcuacgucac gcccgugaag aaccaggggc agugcggcuc cugcugggcc      420

uucagcgcca ccggggcccu ggagggccag auguuccgga agaccgggcg ccugaucucc      480

cucagcgagc agaaccuggu ggacugcucc ggcccgcagg gcaacgaggg gugcaacggc      540

gggcugaugg acuacgccuu ccaguacguc caggacaacg gcggccucga cagcgaggag      600

uccuaccccu acgaggccac cgaggagagc ugcaaguaca accccaagua cuccguggcc      660

aacgacacgg gguucgugga cauccccaag caggagaagg cgcugaugaa ggccgucgcc      720

accgugggcc cgaucagcgu ggccaucgac gccgggcacg aguccuuccu guucuacaag      780

gagggcaucu acuucgagcc cgacugcagc uccgaggaca uggaccacgg gguccucgug      840

gugggcuacg gcuucgagag caccgagucc gacaacaaca aguacuggcu ggucaagaac      900

agcuggggcg aggagugggg gaugggcggg uacgugaaga uggcgaagga ccggcgcaac      960

cacugcggga ucgccagcgc cgccuccuac cccaccgugu ga                        1002


<210>  744
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cathepsin_L__Homo_sapiens__EAW62731

<400>  744
augaacccca cccucauccu cgccgccuuc ugccucggca ucgccuccgc cacccucacc       60

uucgaccacu cccucgaggc ccaguggacc aaguggaagg ccaugcacaa ccgccucuac      120

ggcaugaacg aggagggcug gcgccgcgcc gucugggaga agaacaugaa gaugaucgag      180

cuccacaacc aggaguaccg cgagggcaag cacuccuuca ccauggccau gaacgccuuc      240

ggcgacauga ccuccgagga guuccgccag gucaugaacg gcuuccagaa ccgcaagccc      300

cgcaagggca aggucuucca ggagccccuc uucuacgagg ccccccgcuc cgucgacugg      360

cgcgagaagg gcuacgucac ccccgucaag aaccagggcc agugcggcuc cugcugggcc      420

uucuccgcca ccggcgcccu cgagggccag auguuccgca agaccggccg ccucaucucc      480

cucuccgagc agaaccucgu cgacugcucc ggcccccagg gcaacgaggg cugcaacggc      540

ggccucaugg acuacgccuu ccaguacguc caggacaacg gcggccucga cuccgaggag      600

uccuaccccu acgaggccac cgaggagucc ugcaaguaca accccaagua cuccgucgcc      660

aacgacaccg gcuucgucga cauccccaag caggagaagg cccucaugaa ggccgucgcc      720

accgucggcc ccaucuccgu cgccaucgac gccggccacg aguccuuccu cuucuacaag      780

gagggcaucu acuucgagcc cgacugcucc uccgaggaca uggaccacgg cguccucguc      840

gucggcuacg gcuucgaguc caccgagucc gacaacaaca aguacuggcu cgucaagaac      900

uccuggggcg aggagugggg caugggcggc uacgucaaga uggccaagga ccgccgcaac      960

cacugcggca ucgccuccgc cgccuccuac cccaccgucu ga                        1002


<210>  745
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cathepsin_L__Homo_sapiens__EAW62731

<400>  745
augaacccca cccugauccu cgccgcuuuc ugccuuggca uugcaagcgc cacacugacu       60

uuugaccacu ccuuggaggc gcaguggacg aaguggaaag cuaugcauaa uagauuauac      120

gggaugaacg aagagggaug gaggcgggcc gugugggaaa agaauaugaa aaugauagag      180

cugcacaacc aagaauaucg cgaggguaag cauucuuuca ccauggcaau gaaugccuuu      240

ggcgauauga caucagagga guuccgacag gucaugaacg gguuucagaa ucguaaaccu      300

agaaagggaa agguuuucca ggaaccacua uuuuacgaag cuccgaggag uguggacugg      360

cgggagaaag gcuauguaac ucccgugaag aaccaagguc agugugggag cugcugggca      420

uucuccgcca ccggagcucu cgagggccag auguuucgca aaacaggcag acugaucucu      480

cuuucggaac agaaucuggu cgauuguuca gggccucaag gaaacgaggg uugcaauggc      540

ggguugaugg acuacgccuu ccaguaugug caggauaacg gaggccucga cagcgaagag      600

aguuacccau augaagcgac cgaggagucc uguaaguaca aucccaaaua cucuguugca      660

aacgauacug guuuugugga cauuccuaag caggaaaagg cccugaugaa agcugucgcc      720

acaguggggc caaucagcgu agcaauugau gcuggacacg aguccuuccu guuuuauaag      780

gaaggcaucu acuucgagcc cgacugcuca agugaagaua uggaccaugg cguucucgug      840

gucggguaug gauucgagag caccgagucu gauaauaaca aauacugguu agugaagaac      900

uccuggggug aagagugggg caugggaggg uaugugaaaa uggccaagga caggcggaau      960

cacuguggca uagcgucagc cgcaagcuac ccuacggucu ga                        1002


<210>  746
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cathepsin_L__Homo_sapiens__EAW62731

<400>  746
augaacccca cccugauccu ggccgccuuc ugccugggca ucgccagcgc cacccugacc       60

uucgaccaca gccuggaggc ccaguggacc aaguggaagg ccaugcacaa cagacuguac      120

ggcaugaacg aggagggcug gagaagagcc gugugggaga agaacaugaa gaugaucgag      180

cugcacaacc aggaguacag agagggcaag cacagcuuca ccauggccau gaacgccuuc      240

ggcgacauga ccagcgagga guucagacag gugaugaacg gcuuccagaa cagaaagccc      300

agaaagggca agguguucca ggagccccug uucuacgagg cccccagaag cguggacugg      360

agagagaagg gcuacgugac ccccgugaag aaccagggcc agugcggcag cugcugggcc      420

uucagcgcca ccggcgcccu ggagggccag auguucagaa agaccggcag acugaucagc      480

cugagcgagc agaaccuggu ggacugcagc ggcccccagg gcaacgaggg cugcaacggc      540

ggccugaugg acuacgccuu ccaguacgug caggacaacg gcggccugga cagcgaggag      600

agcuaccccu acgaggccac cgaggagagc ugcaaguaca accccaagua cagcguggcc      660

aacgacaccg gcuucgugga cauccccaag caggagaagg cccugaugaa ggccguggcc      720

accgugggcc ccaucagcgu ggccaucgac gccggccacg agagcuuccu guucuacaag      780

gagggcaucu acuucgagcc cgacugcagc agcgaggaca uggaccacgg cgugcuggug      840

gugggcuacg gcuucgagag caccgagagc gacaacaaca aguacuggcu ggugaagaac      900

agcuggggcg aggagugggg caugggcggc uacgugaaga uggccaagga cagaagaaac      960

cacugcggca ucgccagcgc cgccagcuac cccaccgugu ga                        1002


<210>  747
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cathepsin_L__Homo_sapiens__EAW62731

<400>  747
augaacccca cccugauccu cgccgcuuuc ugccugggca uugccagcgc gacacuuacg       60

uuugaccacu cccuggaggc ucaguggacc aaguggaaag ccaugcauaa uagacucuac      120

gggaugaacg aagagggaug gcggcgcgcc gugugggaaa agaauaugaa aaugaucgag      180

cugcacaacc aagaauauag agagggcaag cauucuuuca caauggcuau gaaugccuuu      240

ggggauauga ccagcgagga auuucggcag gucaugaacg gauuucagaa ucgcaaaccu      300

agaaagggca agguuuucca ggagccgcuu uucuacgaag cuccccgguc cguggacugg      360

cgcgagaaag gguaugugac accugucaag aaccaaggac aguguggcuc uugcugggcc      420

uucagcgcga ccggcgcccu ggaggggcag auguuuagaa aaacaggacg gcucauuucc      480

cugucugaac agaaucuggu ggauuguagc ggcccccaag ggaacgaggg augcaauggc      540

gggcucaugg acuacgcuuu ccaguauguu caggauaacg gaggccugga cuccgaagag      600

agcuacccuu augaagccac cgaggagucu uguaaguaca aucccaaaua cuccguggcu      660

aacgauacgg gcuuugucga caucccuaag caggaaaagg cccuuaugaa agcgguggcc      720

accguugggc cgauuagcgu ggcuaucgau gccggacacg agucuuuccu guuuuauaag      780

gaaggcaucu acuucgagcc cgacugcucc agcgaagaua uggaccaugg gguccucgug      840

gugggauaug gcuucgaguc uacagagucc gauaauaaca aauacuggcu ggucaagaac      900

agcuggggag aagagugggg gaugggcggc uauguuaaaa uggcuaagga ccgcagaaau      960

cacuguggga uugccuccgc cgcuucuuac ccuaccgugu ga                        1002


<210>  748
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__P07711

<400>  748

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  749
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__AAA66974

<400>  749
augaauccua cacucauccu ugcugccuuu ugccugggaa uugccucagc uacucuaaca       60

uuugaucaca guuuagaggc acaguggacc aaguggaagg cgaugcacaa cagauuauac      120

ggcaugaaug aagaaggaug gaggagagca gugugggaga agaacaugaa gaugauugaa      180

cugcacaauc aggaauacag ggaagggaaa cacagcuuca caauggccau gaacgccuuu      240

ggagacauga ccagugaaga auucaggcag gugaugaaug gcuuucaaaa ccguaagccc      300

aggaagggga aaguguucca ggaaccucug uuuuaugagg cccccagauc uguggauugg      360

agagagaaag gcuacgugac uccugugaag aaucaggguc agugugguuc uuguugggcu      420

uuuagugcua cuggugcucu ugaaggacag auguuccgga aaacugggag gcuuaucuca      480

cugagugagc agaaucuggu agacugcucu gggccucaag gcaaugaagg cugcaauggu      540

ggccuaaugg auuaugcuuu ccaguauguu caggauaaug gaggccugga cucugaggaa      600

uccuauccau augaggcaac agaagaaucc uguaaguaca aucccaagua uucuguugcu      660

aaugacaccg gcuuugugga caucccuaag caggagaagg cccugaugaa ggcaguugca      720

acuguggggc ccauuucugu ugcuauugau gcaggucaug aguccuuccu guucuauaaa      780

gaaggcauuu auuuugagcc agacuguagc agugaagaca uggaucaugg ugugcuggug      840

guuggcuacg gauuugaaag cacagaauca gauaacaaua aauauuggcu ggugaagaac      900

agcuggggug aagaaugggg cauggguggc uacguaaaga uggccaaaga ccggagaaac      960

cauuguggaa uugccucagc agccagcuac cccacugugu ga                        1002


<210>  750
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cathepsin_L__Homo_sapiens__AAA66974

<400>  750
augaacccca cccugauccu cgccgccuuc ugccugggca ucgcgagcgc cacccugacg       60

uucgaccacu cccucgaggc ccaguggacc aaguggaagg ccaugcacaa ccgccuguac      120

gggaugaacg aggagggcug gcggcgcgcc gugugggaga agaacaugaa gaugaucgag      180

cugcacaacc aggaguaccg ggaggggaag cacagcuuca ccauggcgau gaacgccuuc      240

ggcgacauga ccuccgagga guuccgccag gucaugaacg gguuccagaa ccggaagccg      300

cgcaagggca agguguucca ggagccccuc uucuacgagg cgccccggag cguggacugg      360

cgcgagaagg gcuacgucac gcccgugaag aaccaggggc agugcggcuc cugcugggcc      420

uucagcgcca ccggggcccu ggagggccag auguuccgga agaccgggcg ccugaucucc      480

cucagcgagc agaaccuggu ggacugcucc ggcccgcagg gcaacgaggg gugcaacggc      540

gggcugaugg acuacgccuu ccaguacguc caggacaacg gcggccucga cagcgaggag      600

uccuaccccu acgaggccac cgaggagagc ugcaaguaca accccaagua cuccguggcc      660

aacgacacgg gguucgugga cauccccaag caggagaagg cgcugaugaa ggccgucgcc      720

accgugggcc cgaucagcgu ggccaucgac gccgggcacg aguccuuccu guucuacaag      780

gagggcaucu acuucgagcc cgacugcagc uccgaggaca uggaccacgg gguccucgug      840

gugggcuacg gcuucgagag caccgagucc gacaacaaca aguacuggcu ggucaagaac      900

agcuggggcg aggagugggg gaugggcggg uacgugaaga uggcgaagga ccggcgcaac      960

cacugcggga ucgccagcgc cgccuccuac cccaccgugu ga                        1002


<210>  751
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cathepsin_L__Homo_sapiens__AAA66974

<400>  751
augaacccca cccucauccu cgccgccuuc ugccucggca ucgccuccgc cacccucacc       60

uucgaccacu cccucgaggc ccaguggacc aaguggaagg ccaugcacaa ccgccucuac      120

ggcaugaacg aggagggcug gcgccgcgcc gucugggaga agaacaugaa gaugaucgag      180

cuccacaacc aggaguaccg cgagggcaag cacuccuuca ccauggccau gaacgccuuc      240

ggcgacauga ccuccgagga guuccgccag gucaugaacg gcuuccagaa ccgcaagccc      300

cgcaagggca aggucuucca ggagccccuc uucuacgagg ccccccgcuc cgucgacugg      360

cgcgagaagg gcuacgucac ccccgucaag aaccagggcc agugcggcuc cugcugggcc      420

uucuccgcca ccggcgcccu cgagggccag auguuccgca agaccggccg ccucaucucc      480

cucuccgagc agaaccucgu cgacugcucc ggcccccagg gcaacgaggg cugcaacggc      540

ggccucaugg acuacgccuu ccaguacguc caggacaacg gcggccucga cuccgaggag      600

uccuaccccu acgaggccac cgaggagucc ugcaaguaca accccaagua cuccgucgcc      660

aacgacaccg gcuucgucga cauccccaag caggagaagg cccucaugaa ggccgucgcc      720

accgucggcc ccaucuccgu cgccaucgac gccggccacg aguccuuccu cuucuacaag      780

gagggcaucu acuucgagcc cgacugcucc uccgaggaca uggaccacgg cguccucguc      840

gucggcuacg gcuucgaguc caccgagucc gacaacaaca aguacuggcu cgucaagaac      900

uccuggggcg aggagugggg caugggcggc uacgucaaga uggccaagga ccgccgcaac      960

cacugcggca ucgccuccgc cgccuccuac cccaccgucu ga                        1002


<210>  752
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cathepsin_L__Homo_sapiens__AAA66974

<400>  752
augaacccca cccugauccu cgccgcuuuc ugccuuggca uugcaagcgc cacacugacu       60

uuugaccacu ccuuggaggc gcaguggacg aaguggaaag cuaugcauaa uagauuauac      120

gggaugaacg aagagggaug gaggcgggcc gugugggaaa agaauaugaa aaugauagag      180

cugcacaacc aagaauaucg cgaggguaag cauucuuuca ccauggcaau gaaugccuuu      240

ggcgauauga caucagagga guuccgacag gucaugaacg gguuucagaa ucguaaaccu      300

agaaagggaa agguuuucca ggaaccacua uuuuacgaag cuccgaggag uguggacugg      360

cgggagaaag gcuauguaac ucccgugaag aaccaagguc agugugggag cugcugggca      420

uucuccgcca ccggagcucu cgagggccag auguuucgca aaacaggcag acugaucucu      480

cuuucggaac agaaucuggu cgauuguuca gggccucaag gaaacgaggg uugcaauggc      540

ggguugaugg acuacgccuu ccaguaugug caggauaacg gaggccucga cagcgaagag      600

aguuacccau augaagcgac cgaggagucc uguaaguaca aucccaaaua cucuguugca      660

aacgauacug guuuugugga cauuccuaag caggaaaagg cccugaugaa agcugucgcc      720

acaguggggc caaucagcgu agcaauugau gcuggacacg aguccuuccu guuuuauaag      780

gaaggcaucu acuucgagcc cgacugcuca agugaagaua uggaccaugg cguucucgug      840

gucggguaug gauucgagag caccgagucu gauaauaaca aauacugguu agugaagaac      900

uccuggggug aagagugggg caugggaggg uaugugaaaa uggccaagga caggcggaau      960

cacuguggca uagcgucagc cgcaagcuac ccuacggucu ga                        1002


<210>  753
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cathepsin_L__Homo_sapiens__AAA66974

<400>  753
augaacccca cccugauccu ggccgccuuc ugccugggca ucgccagcgc cacccugacc       60

uucgaccaca gccuggaggc ccaguggacc aaguggaagg ccaugcacaa cagacuguac      120

ggcaugaacg aggagggcug gagaagagcc gugugggaga agaacaugaa gaugaucgag      180

cugcacaacc aggaguacag agagggcaag cacagcuuca ccauggccau gaacgccuuc      240

ggcgacauga ccagcgagga guucagacag gugaugaacg gcuuccagaa cagaaagccc      300

agaaagggca agguguucca ggagccccug uucuacgagg cccccagaag cguggacugg      360

agagagaagg gcuacgugac ccccgugaag aaccagggcc agugcggcag cugcugggcc      420

uucagcgcca ccggcgcccu ggagggccag auguucagaa agaccggcag acugaucagc      480

cugagcgagc agaaccuggu ggacugcagc ggcccccagg gcaacgaggg cugcaacggc      540

ggccugaugg acuacgccuu ccaguacgug caggacaacg gcggccugga cagcgaggag      600

agcuaccccu acgaggccac cgaggagagc ugcaaguaca accccaagua cagcguggcc      660

aacgacaccg gcuucgugga cauccccaag caggagaagg cccugaugaa ggccguggcc      720

accgugggcc ccaucagcgu ggccaucgac gccggccacg agagcuuccu guucuacaag      780

gagggcaucu acuucgagcc cgacugcagc agcgaggaca uggaccacgg cgugcuggug      840

gugggcuacg gcuucgagag caccgagagc gacaacaaca aguacuggcu ggugaagaac      900

agcuggggcg aggagugggg caugggcggc uacgugaaga uggccaagga cagaagaaac      960

cacugcggca ucgccagcgc cgccagcuac cccaccgugu ga                        1002


<210>  754
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cathepsin_L__Homo_sapiens__AAA66974

<400>  754
augaacccca cccugauccu cgccgcuuuc ugccugggca uugccagcgc gacacuuacg       60

uuugaccacu cccuggaggc ucaguggacc aaguggaaag ccaugcauaa uagacucuac      120

gggaugaacg aagagggaug gcggcgcgcc gugugggaaa agaauaugaa aaugaucgag      180

cugcacaacc aagaauauag agagggcaag cauucuuuca caauggcuau gaaugccuuu      240

ggggauauga ccagcgagga auuucggcag gucaugaacg gauuucagaa ucgcaaaccu      300

agaaagggca agguuuucca ggagccgcuu uucuacgaag cuccccgguc cguggacugg      360

cgcgagaaag gguaugugac accugucaag aaccaaggac aguguggcuc uugcugggcc      420

uucagcgcga ccggcgcccu ggaggggcag auguuuagaa aaacaggacg gcucauuucc      480

cugucugaac agaaucuggu ggauuguagc ggcccccaag ggaacgaggg augcaauggc      540

gggcucaugg acuacgcuuu ccaguauguu caggauaacg gaggccugga cuccgaagag      600

agcuacccuu augaagccac cgaggagucu uguaaguaca aucccaaaua cuccguggcu      660

aacgauacgg gcuuugucga caucccuaag caggaaaagg cccuuaugaa agcgguggcc      720

accguugggc cgauuagcgu ggcuaucgau gccggacacg agucuuuccu guuuuauaag      780

gaaggcaucu acuucgagcc cgacugcucc agcgaagaua uggaccaugg gguccucgug      840

gugggauaug gcuucgaguc uacagagucc gauaauaaca aauacuggcu ggucaagaac      900

agcuggggag aagagugggg gaugggcggc uauguuaaaa uggcuaagga ccgcagaaau      960

cacuguggga uugccuccgc cgcuucuuac ccuaccgugu ga                        1002


<210>  755
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__Q9HBQ7

<400>  755

Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp Asn Gly Gly Leu Asp Ser 
1               5                   10                  15      


Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu Glu Ser Cys Lys Tyr Asn 
            20                  25                  30          


Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Lys 
        35                  40                  45              


Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr Val Gly Pro Ile Ser 
    50                  55                  60                  


Val Ala Ile Asp Ala Gly His Glu Ser Phe Leu Phe Tyr Lys Glu Gly 
65                  70                  75                  80  


Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu Asp Met Asp His Gly Val 
                85                  90                  95      


Leu Val Val Gly Tyr Gly Phe Glu Ser Thr Glu Ser Asp Asn Asn Lys 
            100                 105                 110         


Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu Glu Trp Gly Met Gly Gly 
        115                 120                 125             


Tyr Val Lys Met Ala Lys Asp Arg Arg Asn His Cys Gly Ile Ala Ser 
    130                 135                 140                 


Ala Ala Ser Tyr Pro Thr Val 
145                 150     


<210>  756
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cathepsin_L__Homo_sapiens__AAG17239

<400>  756
auggauuaug cuuuccagua uguucaggau aauggaggcc uggacucuga ggaauccuau       60

ccauaugagg caacagaaga auccuguaag uacaauccca aguauucugu ugcuaaugac      120

accggcuuug uggacauccc uaagcaggag aaggcccuga ugaaggcagu ugcaacugug      180

gggcccauuu cuguugcuau ugaugcaggu caugaguccu uccuguucua uaaagaaggc      240

auuuauuuug agccagacug uagcagugaa gacauggauc auggugugcu ggugguuggc      300

uacggauuug aaagcacaga aucagauaac aauaaauauu ggcuggugaa gaacagcugg      360

ggugaagaau ggggcauggg uggcuacgua aagauggcca aagaccggag aaaccauugu      420

ggaauugccu cagcagccag cuaccccacu guguga                                456


<210>  757
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cathepsin_L__Homo_sapiens__AAG17239

<400>  757
auggacuacg ccuuccagua cgugcaggac aacggcgggc uggacagcga ggaguccuac       60

cccuacgagg ccaccgagga gagcugcaag uacaacccga aguacuccgu cgcgaacgac      120

accggcuucg uggacauccc caagcaggag aaggcccuca ugaaggccgu ggccacgguc      180

gggcccauca gcguggccau cgacgcgggc cacgaguccu uccuguucua caaggagggg      240

aucuacuucg agcccgacug cagcuccgag gacauggacc acggcgugcu ggucgugggc      300

uacggguucg agagcaccga guccgacaac aacaaguacu ggcucgugaa gaacagcugg      360

ggcgaggagu gggggauggg cggguacguc aagauggcca aggaccgccg gaaccacugc      420

ggcaucgccu ccgccgcgag cuacccgacc guguga                                456


<210>  758
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cathepsin_L__Homo_sapiens__AAG17239

<400>  758
auggacuacg ccuuccagua cguccaggac aacggcggcc ucgacuccga ggaguccuac       60

cccuacgagg ccaccgagga guccugcaag uacaacccca aguacuccgu cgccaacgac      120

accggcuucg ucgacauccc caagcaggag aaggcccuca ugaaggccgu cgccaccguc      180

ggccccaucu ccgucgccau cgacgccggc cacgaguccu uccucuucua caaggagggc      240

aucuacuucg agcccgacug cuccuccgag gacauggacc acggcguccu cgucgucggc      300

uacggcuucg aguccaccga guccgacaac aacaaguacu ggcucgucaa gaacuccugg      360

ggcgaggagu ggggcauggg cggcuacguc aagauggcca aggaccgccg caaccacugc      420

ggcaucgccu ccgccgccuc cuaccccacc gucuga                                456


<210>  759
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cathepsin_L__Homo_sapiens__AAG17239

<400>  759
auggacuacg ccuuccagua ugugcaagau aacggcgggc uggacagcga ggaauccuac       60

cccuaugagg cuaccgaaga gucuugcaag uacaauccua aauauucagu cgcaaacgau      120

acaggauuug uugacauccc aaagcaggaa aaagcccuca ugaaggcggu ggcuacugua      180

gguccgauua guguggccau agaugcaggc cacgagagcu uccuguuuua caaagagggg      240

aucuauuucg aacccgacug uuccucugag gauauggacc auggaguccu ugugguuggc      300

uacgguuuug aaucgacgga gucagauaau aacaaguacu gguuggugaa gaauagcugg      360

ggagaggaau gggggauggg cggcuauguc aaaauggcca aggacagaag gaaccacugc      420

gggauugcua gugcagccuc cuacccuacc guguga                                456


<210>  760
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cathepsin_L__Homo_sapiens__AAG17239

<400>  760
auggacuacg ccuuccagua cgugcaggac aacggcggcc uggacagcga ggagagcuac       60

cccuacgagg ccaccgagga gagcugcaag uacaacccca aguacagcgu ggccaacgac      120

accggcuucg uggacauccc caagcaggag aaggcccuga ugaaggccgu ggccaccgug      180

ggccccauca gcguggccau cgacgccggc cacgagagcu uccuguucua caaggagggc      240

aucuacuucg agcccgacug cagcagcgag gacauggacc acggcgugcu gguggugggc      300

uacggcuucg agagcaccga gagcgacaac aacaaguacu ggcuggugaa gaacagcugg      360

ggcgaggagu ggggcauggg cggcuacgug aagauggcca aggacagaag aaaccacugc      420

ggcaucgcca gcgccgccag cuaccccacc guguga                                456


<210>  761
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cathepsin_L__Homo_sapiens__AAG17239

<400>  761
auggacuacg ccuuccagua ugugcaagau aacggcgggc uggacagcga ggaauccuac       60

cccuaugagg cuaccgaaga gucuugcaag uacaauccua aauauagcgu cgccaacgau      120

acaggauuug uugacauccc gaagcaggaa aaagcgcuca ugaaggcugu ggccacggug      180

ggccccauuu ccgucgccau cgaugcuggg cacgagucuu uccuguuuua caaagaggga      240

auuuauuucg aaccugacug uagcuccgag gauauggacc auggcgugcu uguugugggg      300

uacggauuug aaucuaccga gagcgauaau aacaaguacu ggcuggucaa aaauuccugg      360

ggcgaggaau ggggcauggg aggguaugug aagauggcca aggacagacg gaaccacugc      420

ggcaucgcua gcgccgcguc uuaccccaca guuuga                                456


<210>  762
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD1A__Homo_sapiens__P06126

<400>  762

Met Leu Phe Leu Leu Leu Pro Leu Leu Ala Val Leu Pro Gly Asp Gly 
1               5                   10                  15      


Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
            20                  25                  30          


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
        35                  40                  45              


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
    50                  55                  60                  


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
65                  70                  75                  80  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
                85                  90                  95      


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
            100                 105                 110         


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
        115                 120                 125             


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
    130                 135                 140                 


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
145                 150                 155                 160 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
                165                 170                 175     


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
            180                 185                 190         


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
        195                 200                 205             


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
    210                 215                 220                 


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
225                 230                 235                 240 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
                245                 250                 255     


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
            260                 265                 270         


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
        275                 280                 285             


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
    290                 295                 300                 


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
305                 310                 315                 320 


Phe Arg Lys Arg Cys Phe Cys 
                325         


<210>  763
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD1A__Homo_sapiens__AAA51932

<400>  763
augcuguuuu ugcuacuucc auuguuagcu guucucccag gugauggcaa ugcagacggg       60

cucaaggagc cucucuccuu ccaugucacc uggaucgcau ccuuuuacaa ccauuccugg      120

aaacaaaauc uggucucagg uuggcugagu gauuugcaga cucauaccug ggacagcaau      180

uccagcacca ucguuuuccu gugccccugg uccaggggaa acuucagcaa ugaggagugg      240

aaggaacugg aaacauuauu ccguauacgc accauucggu cauuugaggg aauucguaga      300

uacgcccaug aauugcaguu ugaauauccu uuugagauac aggugacagg aggcugugag      360

cugcacucug gaaaggucuc aggaagcuuc uugcaguuag cuuaucaagg aucagacuuu      420

gugagcuucc agaacaauuc augguugcca uauccagugg cugggaauau ggccaagcau      480

uucugcaaag ugcucaauca gaaucagcau gaaaaugaca uaacacacaa ucuucucagu      540

gacaccugcc cacguuucau cuugggucuu cuugaugcag gaaaggcaca ucuccagcgg      600

caagugaagc ccgaggccug gcugucccau ggccccaguc cuggcccugg ccaucugcag      660

cuugugugcc augucucagg auucuaccca aagcccgugu gggugaugug gaugcggggu      720

gagcaggagc agcagggcac ucagcgaggg gacaucuugc ccagugcuga ugggacaugg      780

uaucuccgcg caacccugga gguggccgcu ggggaggcag cugaccuguc cugucgggug      840

aagcacagca gucuagaggg ccaggacauc guccucuacu gggagcauca caguuccgug      900

ggcuucauca ucuuggcggu gauagugccu uuacuucuuc ugauaggucu ugcgcuuugg      960

uucaggaaac gcuguuucug uuaa                                             984


<210>  764
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD1A__Homo_sapiens__AAA51932

<400>  764
augcuguucc uccugcugcc ccuccuggcc gugcugccgg gcgacgggaa cgccgacggc       60

cucaaggagc cccugagcuu ccacgucacc uggaucgcgu ccuucuacaa ccacagcugg      120

aagcagaacc ugguguccgg guggcucagc gaccugcaga cccacacgug ggacuccaac      180

agcuccacca ucguguuccu gugccccugg agccgcggca acuucuccaa cgaggagugg      240

aaggagcucg agacccuguu ccggauccgc accauccgga gcuucgaggg gauccgccgg      300

uacgcccacg agcugcaguu cgaguacccc uucgagaucc aggucacggg cggcugcgag      360

cuccacuccg ggaaggugag cggcuccuuc cugcagcugg ccuaccaggg gagcgacuuc      420

guguccuucc agaacaacag cuggcucccg uaccccgucg ccggcaacau ggccaagcac      480

uucugcaagg ugcugaacca gaaccagcac gagaacgaca ucacccacaa ccugcucucc      540

gacacgugcc cccgcuucau ccuggggcug cucgacgcgg gcaaggccca ccuccagcgc      600

caggugaagc ccgaggccug gcugagccac ggcccguccc ccgggcccgg ccaccuccag      660

cuggucugcc acgugagcgg guucuacccc aagccggugu gggucaugug gaugcggggc      720

gagcaggagc agcagggcac ccagcgcggg gacauccugc ccagcgccga cggcaccugg      780

uaccugcggg cgacccugga gguggccgcc ggggaggccg ccgaccuguc cugccgggug      840

aagcacagcu cccucgaggg ccaggacauc guccuguacu gggagcacca cagcuccgug      900

ggguucauca uccuggcggu gaucgucccc cuccugcugc ucaucggccu ggcccugugg      960

uuccgcaagc ggugcuucug cuga                                             984


<210>  765
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD1A__Homo_sapiens__AAA51932

<400>  765
augcucuucc uccuccuccc ccuccucgcc guccuccccg gcgacggcaa cgccgacggc       60

cucaaggagc cccucuccuu ccacgucacc uggaucgccu ccuucuacaa ccacuccugg      120

aagcagaacc ucgucuccgg cuggcucucc gaccuccaga cccacaccug ggacuccaac      180

uccuccacca ucgucuuccu cugccccugg ucccgcggca acuucuccaa cgaggagugg      240

aaggagcucg agacccucuu ccgcauccgc accauccgcu ccuucgaggg cauccgccgc      300

uacgcccacg agcuccaguu cgaguacccc uucgagaucc aggucaccgg cggcugcgag      360

cuccacuccg gcaaggucuc cggcuccuuc cuccagcucg ccuaccaggg cuccgacuuc      420

gucuccuucc agaacaacuc cuggcucccc uaccccgucg ccggcaacau ggccaagcac      480

uucugcaagg uccucaacca gaaccagcac gagaacgaca ucacccacaa ccuccucucc      540

gacaccugcc cccgcuucau ccucggccuc cucgacgccg gcaaggccca ccuccagcgc      600

caggucaagc ccgaggccug gcucucccac ggccccuccc ccggccccgg ccaccuccag      660

cucgucugcc acgucuccgg cuucuacccc aagcccgucu gggucaugug gaugcgcggc      720

gagcaggagc agcagggcac ccagcgcggc gacauccucc ccuccgccga cggcaccugg      780

uaccuccgcg ccacccucga ggucgccgcc ggcgaggccg ccgaccucuc cugccgcguc      840

aagcacuccu cccucgaggg ccaggacauc guccucuacu gggagcacca cuccuccguc      900

ggcuucauca uccucgccgu caucgucccc cuccuccucc ucaucggccu cgcccucugg      960

uuccgcaagc gcugcuucug cuga                                             984


<210>  766
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD1A__Homo_sapiens__AAA51932

<400>  766
augcuguucc uccuucugcc cuuguuagcc gugcugccug gcgacgggaa cgcugaugga       60

cuaaaggagc cacucagcuu ucacgucacc uggaucgcau ccuucuacaa ucauucuugg      120

aaacagaacc ugguuucagg uuggcuuagu gaccugcaaa cacacacuug ggauagcaau      180

uccucuacga uuguguuuuu gugcccgugg ucgagaggca acuucucaaa ugaagagugg      240

aaggaacucg agacccuguu uaggauacgg acaauccgca gcuucgaagg gauucgacgu      300

uaugcccaug agcugcaguu ugaguacccc uucgaaaucc agguaacugg aggcugugag      360

cuccacagug guaaaguguc cgggagcuuu uuacagcugg cguaucaagg aucugacuuc      420

gucuccuuuc agaacaauuc auggcuuccu uacccagugg cuggcaacau ggccaagcau      480

uucugcaaag uuuugaauca gaaccagcac gaaaaugaua uuacccacaa ccugcuaagu      540

gacacauguc ccagauuuau ccucggccug cuugaugcag ggaaggccca ucugcaaagg      600

caagugaagc cugaggcuug guugagccac ggaccaucuc ccgguccugg ccaucuccag      660

cuggucugcc acguguccgg guucuaucca aaaccgguau ggguuaugug gaugcgggga      720

gagcaggaac agcagggcac ccagcgcggu gacauauuac ccucagcaga ugggacuugg      780

uaccugagag ccacacucga gguggcugcc ggagaagcgg cagaccuuag cuguaggguc      840

aagcacaguu cucuggaggg ccaagauauc guguuguauu gggaacauca cuccagcgug      900

ggcuucauua uccuagccgu cauuguuccu cugcuccugc uuaucgggcu ggcuuugugg      960

uuucggaaac gcugcuucug uuga                                             984


<210>  767
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD1A__Homo_sapiens__AAA51932

<400>  767
augcuguucc ugcugcugcc ccugcuggcc gugcugcccg gcgacggcaa cgccgacggc       60

cugaaggagc cccugagcuu ccacgugacc uggaucgcca gcuucuacaa ccacagcugg      120

aagcagaacc uggugagcgg cuggcugagc gaccugcaga cccacaccug ggacagcaac      180

agcagcacca ucguguuccu gugccccugg agcagaggca acuucagcaa cgaggagugg      240

aaggagcugg agacccuguu cagaaucaga accaucagaa gcuucgaggg caucagaaga      300

uacgcccacg agcugcaguu cgaguacccc uucgagaucc aggugaccgg cggcugcgag      360

cugcacagcg gcaaggugag cggcagcuuc cugcagcugg ccuaccaggg cagcgacuuc      420

gugagcuucc agaacaacag cuggcugccc uaccccgugg ccggcaacau ggccaagcac      480

uucugcaagg ugcugaacca gaaccagcac gagaacgaca ucacccacaa ccugcugagc      540

gacaccugcc ccagauucau ccugggccug cuggacgccg gcaaggccca ccugcagaga      600

caggugaagc ccgaggccug gcugagccac ggccccagcc ccggccccgg ccaccugcag      660

cuggugugcc acgugagcgg cuucuacccc aagcccgugu gggugaugug gaugagaggc      720

gagcaggagc agcagggcac ccagagaggc gacauccugc ccagcgccga cggcaccugg      780

uaccugagag ccacccugga gguggccgcc ggcgaggccg ccgaccugag cugcagagug      840

aagcacagca gccuggaggg ccaggacauc gugcuguacu gggagcacca cagcagcgug      900

ggcuucauca uccuggccgu gaucgugccc cugcugcugc ugaucggccu ggcccugugg      960

uucagaaaga gaugcuucug cuga                                             984


<210>  768
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD1A__Homo_sapiens__AAA51932

<400>  768
augcuguucc uccugcuucc ccugcucgcc gugcugccug gcgacgggaa cgcugaugga       60

cuuaaggagc cgcugagcuu ucacgucacc uggaucgccu ccuucuacaa ucauucuugg      120

aaacagaacc ucguuagcgg cuggcugucc gaccugcaaa cacacacgug ggauucuaau      180

agcuccacca uuguguuucu cugccccugg ucuagaggga acuucagcaa ugaagagugg      240

aaggaacugg agacacuuuu ucggauccgc accauuagau ccuucgaagg aauccggcgc      300

uaugcgcaug agcugcaguu ugaguacccu uucgaaauuc aggugacagg cgggugugag      360

cuccacagcg gaaaagucuc uggcuccuuu cugcagcuug cuuaucaagg cagcgacuuc      420

gugucuuuuc agaacaauuc cuggcugccc uacccuguug ccgggaacau ggccaagcau      480

uucugcaaag ugcucaauca gaaccagcac gaaaaugaua ucacccacaa ccugcugagc      540

gacacauguc ccagauuuau ccucggacug cuugaugcug gcaaggccca ucugcaacgg      600

caggucaagc cugaggcuug gcucucucac gggccguccc ccggaccugg ccaucugcag      660

cuugugugcc acguuagcgg guucuauccc aaaccugugu gggucaugug gaugcgcgga      720

gagcaggaac aacagggcac ccagagaggc gacauucugc ccuccgccga ugggacgugg      780

uaccuccggg cgacccugga gguggccgcu ggagaagccg cugaccuguc uugucgcgug      840

aagcacagcu cccucgaggg ccaagauauc guccuguauu gggaacauca cagcucuguu      900

ggguucauua uccuugccgu gauugugccg cugcuccugc uuaucggacu ggcgcucugg      960

uuuagaaaac ggugcuucug uuga                                             984


<210>  769
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD1B__Homo_sapiens__P29016

<400>  769

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln 
            20                  25                  30          


Thr Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr 
    50                  55                  60                  


Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu 
65                  70                  75                  80  


Val Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala 
                85                  90                  95      


Arg Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe 
            100                 105                 110         


Glu Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile 
        115                 120                 125             


Val Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val 
    130                 135                 140                 


Lys Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln 
145                 150                 155                 160 


Lys Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val 
                165                 170                 175     


Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu 
            180                 185                 190         


Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp 
        195                 200                 205             


Leu Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile 
    290                 295                 300                 


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Leu Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
                325                 330             


<210>  770
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD1B__Homo_sapiens__AAA51939

<400>  770
augcugcugc ugccauuuca acuguuagcu guucucuuuc cuggugguaa cagugaacau       60

gccuuccagg ggccgaccuc cuuucauguu auccagaccu cguccuuuac caauaguacc      120

ugggcacaaa cucaaggcuc aggcugguug gaugauuugc agauucaugg cugggauagc      180

gacucaggca cugccauauu ccugaagccu uggucuaaag guaacuuuag ugauaaggag      240

guugcugagu uagaggagau auuccgaguc uacaucuuug gauucgcucg agaaguacaa      300

gacuuugccg gugauuucca gaugaaauac cccuuugaga uccagggcau agcaggcugu      360

gagcuacauu cuggaggugc cauaguaagc uuccugaggg gagcucuagg aggauuggau      420

uuccugagug ucaagaaugc uucaugugug ccuuccccag aagguggcag cagggcacag      480

aaauucugug cacuaaucau acaauaucaa gguaucaugg aaacugugag aauucuccuc      540

uaugaaaccu gcccccgaua ucucuugggc guccucaaug caggaaaagc agaucugcaa      600

agacaaguga agccugaggc cuggcugucc aguggcccca guccuggacc uggccgucug      660

cagcuugugu gccaugucuc aggauucuac ccaaagcccg ugugggugau guggaugcgg      720

ggugagcagg agcagcaggg cacucagcua ggggacaucc ugcccaaugc uaacuggaca      780

ugguaucucc gagcaacccu ggauguggca gauggggagg cggcuggccu guccugucgg      840

gugaagcaca gcaguuuaga gggccaggac aucauccucu acuggagaaa ccccaccucc      900

auuggcucaa uuguuuuggc aauaauagug ccuuccuugc uccuuuugcu augccuugca      960

uuaugguaua ugaggcgccg gucauaucag aauaucccau ga                        1002


<210>  771
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD1B__Homo_sapiens__AAA51939

<400>  771
augcugcucc ugcccuucca gcugcucgcc gugcuguucc cgggcgggaa cagcgagcac       60

gccuuccagg gccccaccuc cuuccacguc auccagacca gcuccuucac gaacagcacc      120

ugggcgcaga cccagggguc cggcuggcug gacgaccucc agauccacgg gugggacagc      180

gacuccggca ccgccaucuu ccugaagccc uggagcaagg gcaacuucuc cgacaaggag      240

guggccgagc uggaggagau cuuccgcgug uacaucuucg gguucgcccg ggagguccag      300

gacuucgccg gcgacuucca gaugaaguac cccuucgaga uccaggggau cgcgggcugc      360

gagcuccaca gcgggggcgc caucgugucc uuccugcgcg gcgcccucgg gggccuggac      420

uuccugagcg ugaagaacgc cuccugcguc ccgagccccg agggcggguc ccgggcgcag      480

aaguucugcg cccugaucau ccaguaccag ggcaucaugg agacggugcg cauccuccug      540

uacgagaccu gcccccggua ccugcucggg gugcugaacg ccggcaaggc cgaccugcag      600

cgccagguca agcccgaggc cuggcucagc uccgggccga gccccggccc cgggcggcug      660

cagcuggugu gccacguguc cggcuucuac cccaagccgg ucugggugau guggaugcgc      720

ggcgagcagg agcagcaggg gacccagcuc ggcgacaucc ugcccaacgc gaacuggacc      780

ugguaccugc gggccacgcu cgacguggcc gacggggagg ccgccggccu gagcugccgc      840

gucaagcaca gcucccugga ggggcaggac aucauccucu acuggcggaa ccccaccagc      900

aucggcucca ucgugcuggc gaucaucgug cccagccugc uccugcugcu cugccuggcc      960

cugugguaca ugcgccggcg cuccuaccag aacaucccgu ga                        1002


<210>  772
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD1B__Homo_sapiens__AAA51939

<400>  772
augcuccucc uccccuucca gcuccucgcc guccucuucc ccggcggcaa cuccgagcac       60

gccuuccagg gccccaccuc cuuccacguc auccagaccu ccuccuucac caacuccacc      120

ugggcccaga cccagggcuc cggcuggcuc gacgaccucc agauccacgg cugggacucc      180

gacuccggca ccgccaucuu ccucaagccc ugguccaagg gcaacuucuc cgacaaggag      240

gucgccgagc ucgaggagau cuuccgcguc uacaucuucg gcuucgcccg cgagguccag      300

gacuucgccg gcgacuucca gaugaaguac cccuucgaga uccagggcau cgccggcugc      360

gagcuccacu ccggcggcgc caucgucucc uuccuccgcg gcgcccucgg cggccucgac      420

uuccucuccg ucaagaacgc cuccugcguc cccucccccg agggcggcuc ccgcgcccag      480

aaguucugcg cccucaucau ccaguaccag ggcaucaugg agaccguccg cauccuccuc      540

uacgagaccu gcccccgcua ccuccucggc guccucaacg ccggcaaggc cgaccuccag      600

cgccagguca agcccgaggc cuggcucucc uccggccccu cccccggccc cggccgccuc      660

cagcucgucu gccacgucuc cggcuucuac cccaagcccg ucugggucau guggaugcgc      720

ggcgagcagg agcagcaggg cacccagcuc ggcgacaucc uccccaacgc caacuggacc      780

ugguaccucc gcgccacccu cgacgucgcc gacggcgagg ccgccggccu cuccugccgc      840

gucaagcacu ccucccucga gggccaggac aucauccucu acuggcgcaa ccccaccucc      900

aucggcucca ucguccucgc caucaucguc cccucccucc uccuccuccu cugccucgcc      960

cucugguaca ugcgccgccg cuccuaccag aacauccccu ga                        1002


<210>  773
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD1B__Homo_sapiens__AAA51939

<400>  773
augcugcucc uucccuucca gcuguuggcc guguuauuuc cuggcgggaa cagcgagcac       60

gcuuuccaag gaccaaccuc cuuucauguc auccagacau cuucauucac uaauaguacg      120

ugggcacaga cccaggguag cggcuggcug gacgaucuac aaauucacgg gugggacucc      180

gauucuggaa cagccauauu ucucaagccg uggucgaaag gcaacuucuc agacaaggaa      240

guugcggagc uggaagagau cuuuagagug uacauuuucg guuuugcuag ggaaguacag      300

gauuucgccg gggacuuuca gaugaaauau cccuucgaga uccagggaau ugcaggcugc      360

gagcuucaua gcggcggggc caucgugagu uuucugcggg gagcuuuggg uggccucgau      420

uuccuguccg ucaagaaugc aucuugugug ccuagcccag aagggggauc ccgcgcccaa      480

aaauucugcg cucugauaau ccaguaccag ggcauuaugg agacuguucg aauccucuua      540

uaugaaaccu guccccguua ccugcuuggu guguugaacg ccgggaaggc ggaccugcag      600

agacaaguca agccugaggc auggcuauca aguggaccaa gccccggccc uggcaggcuc      660

cagcuggugu gccacguauc uggguuuuau ccaaaaccgg uuugggugau guggaugcgg      720

ggagagcagg aacaacaggg uacacagcuu ggcgauauuc ugcccaaugc caacuggacc      780

ugguacuugc gcgcuacucu cgacgucgcc gauggggagg cagcuggacu guccuguaga      840

gugaagcaua gcucauuaga aggccaggac aucauacugu auuggaggaa uccuacaagu      900

auugguucua ucgugcucgc cauuaucguc ccaucccuuc uguugcuacu gugccucgcg      960

cugugguaca ugcggcgccg aagcuaccaa aacauccccu ga                        1002


<210>  774
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD1B__Homo_sapiens__AAA51939

<400>  774
augcugcugc ugcccuucca gcugcuggcc gugcuguucc ccggcggcaa cagcgagcac       60

gccuuccagg gccccaccag cuuccacgug auccagacca gcagcuucac caacagcacc      120

ugggcccaga cccagggcag cggcuggcug gacgaccugc agauccacgg cugggacagc      180

gacagcggca ccgccaucuu ccugaagccc uggagcaagg gcaacuucag cgacaaggag      240

guggccgagc uggaggagau cuucagagug uacaucuucg gcuucgccag agaggugcag      300

gacuucgccg gcgacuucca gaugaaguac cccuucgaga uccagggcau cgccggcugc      360

gagcugcaca gcggcggcgc caucgugagc uuccugagag gcgcccuggg cggccuggac      420

uuccugagcg ugaagaacgc cagcugcgug cccagccccg agggcggcag cagagcccag      480

aaguucugcg cccugaucau ccaguaccag ggcaucaugg agaccgugag aauccugcug      540

uacgagaccu gccccagaua ccugcugggc gugcugaacg ccggcaaggc cgaccugcag      600

agacagguga agcccgaggc cuggcugagc agcggcccca gccccggccc cggcagacug      660

cagcuggugu gccacgugag cggcuucuac cccaagcccg ugugggugau guggaugaga      720

ggcgagcagg agcagcaggg cacccagcug ggcgacaucc ugcccaacgc caacuggacc      780

ugguaccuga gagccacccu ggacguggcc gacggcgagg ccgccggccu gagcugcaga      840

gugaagcaca gcagccugga gggccaggac aucauccugu acuggagaaa ccccaccagc      900

aucggcagca ucgugcuggc caucaucgug cccagccugc ugcugcugcu gugccuggcc      960

cugugguaca ugagaagaag aagcuaccag aacauccccu ga                        1002


<210>  775
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD1B__Homo_sapiens__AAA51939

<400>  775
augcugcucc ugcccuucca gcuucuggcc gugcucuuuc cuggcgggaa cagcgagcac       60

gcuuuccaag gaccgaccuc cuuucauguc auccagacau cuagcuucac caauuccacg      120

ugggcccaga cacagggcuc uggguggcug gacgaucuuc aaauucacgg augggacagc      180

gauuccggca ccgcgaucuu ucugaagccc uggucuaaag ggaacuucag cgacaaggaa      240

guugcugagc ucgaagagau uuuuagagug uacaucuucg gauuugcccg ggaagugcag      300

gauuucgccg gcgacuuuca gaugaaauau ccuuucgaga uucagggcau cgcugggugc      360

gagcugcauu ccggaggcgc caucgucagc uuucugcgcg gggcucucgg aggccuggau      420

uuccuuucug ugaagaaugc cuccuguguu cccagcccug aagggggauc uagagcgcaa      480

aaauucugcg cccugauuau ccaguaccag ggcauuaugg agacagugcg gauccuccug      540

uaugaaaccu guccccgcua ccuucugggc guccucaacg cugggaaggc cgaccugcag      600

agacaaguga agccugaggc uuggcugucc agcggaccgu cucccggccc ugggcggcuc      660

cagcugguuu gccacguguc cggauuuuau cccaaaccug ucugggugau guggaugcgc      720

ggcgagcagg aacaacaggg gacacagcuu ggagauauuc ugcccaaugc caacuggacc      780

ugguaccuca gagcgacgcu ggacguggcc gauggcgagg cugccggccu uagcugucgg      840

gucaagcauu ccucucugga agggcaggac aucauucucu auuggcgcaa uccgaccagc      900

aucggaucca ucguucuggc uauuaucgug ccuagccugc uccugcuucu gugccucgcc      960

cugugguaca ugagacggcg cucuuaccaa aacauucccu ga                        1002


<210>  776
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD1C__Homo_sapiens__P29017

<400>  776

Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210>  777
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD1C__Homo_sapiens__AAI26466

<400>  777
augcuguuuc ugcaguuucu gcugcuagcu cuucuucucc caggugguga caaugcagac       60

gcaucccagg aacacgucuc cuuccauguc auccagaucu ucucauuugu caaccaaucc      120

ugggcacgag gucagggcuc aggauggcug gacgaguugc agacucaugg cugggacagu      180

gaaucaggca caauaauuuu ccugcauaac ugguccaagg gcaacuucag caaugaagag      240

uugucagacc uagaguuguu auuucguuuc uaccucuuug gauuaacucg ggagauucaa      300

gaccaugcaa gucaagauua cucgaaauau cccuuugaag uacaggugaa agcgggcugu      360

gagcugcauu cuggaaagag cccagaaggc uucuuucagg uagcuuucaa cggauuagau      420

uuacugaguu uccagaauac aacaugggug ccaucuccag gcuguggaag uuuggcccaa      480

agugucuguc aucuacucaa ucaucaguau gaaggcguca cagaaacagu guauaaucuc      540

auaagaagca cuugcccccg auuucucuug ggucuccugg augcagggaa gauguaugua      600

cacaggcaag ugaggccaga agccuggcug uccagucgcc ccagccuugg gucuggccag      660

cuguugcugg uuugucaugc cuccggcuuc uacccaaagc cuguuugggu gacauggaug      720

cggaaugaac aggagcaacu gggcacuaaa cauggugaua uucuuccuaa ugcugauggg      780

acaugguauc uucaggugau ccuggaggug gcaucugagg agccugcugg ccugucuugu      840

cgagugagac acagcagucu aggaggccag gacaucaucc ucuacugggg acaccacuuu      900

uccaugaauu ggauugccuu gguagugaua gugcccuugg ugauucuaau aguccuugug      960

uuaugguuua agaagcacug cucauaucag gacauccugu ga                        1002


<210>  778
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD1C__Homo_sapiens__AAI26466

<400>  778
augcuguucc uccaguuccu gcugcucgcc cugcugcucc ccggcgggga caacgccgac       60

gcgagccagg agcacguguc cuuccacguc auccagaucu ucagcuucgu gaaccagucc      120

ugggcccgcg gccaggggag cggcuggcug gacgagcugc agacccacgg gugggacucc      180

gagagcggca ccaucaucuu ccuccacaac ugguccaagg gcaacuucag caacgaggag      240

cuguccgacc uggagcuccu guuccgguuc uaccuguucg ggcucacgcg cgagauccag      300

gaccacgcca gccaggacua cuccaaguac ccguucgagg ugcaggucaa ggccggcugc      360

gagcugcaca gcgggaaguc ccccgagggc uucuuccagg uggccuucaa cgggcuggac      420

cuccugagcu uccagaacac caccugggug cccucccccg gcugcggcag ccuggcgcag      480

uccgucugcc accuccugaa ccaccaguac gaggggguga ccgagacggu guacaaccug      540

auccggagca cgugcccgcg cuuccuccug ggccugcucg acgccgggaa gauguacguc      600

caccgccagg ugcggcccga ggccuggcug uccagccggc ccagccuggg cuccggccag      660

cuccugcugg ugugccacgc cagcggguuc uaccccaagc cggucugggu gaccuggaug      720

cgcaacgagc aggagcagcu cggcaccaag cacggggaca uccugcccaa cgcggacggc      780

accugguacc uccaggugau ccuggagguc gccuccgagg agcccgccgg gcugagcugc      840

cgggugcgcc acuccagccu gggcggccag gacaucaucc ucuacugggg gcaccacuuc      900

uccaugaacu ggaucgcccu gguggucauc gugccccugg ugauccucau cguccuggug      960

cugugguuca agaagcacug cagcuaccag gacauccucu ga                        1002


<210>  779
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD1C__Homo_sapiens__AAI26466

<400>  779
augcucuucc uccaguuccu ccuccucgcc cuccuccucc ccggcggcga caacgccgac       60

gccucccagg agcacgucuc cuuccacguc auccagaucu ucuccuucgu caaccagucc      120

ugggcccgcg gccagggcuc cggcuggcuc gacgagcucc agacccacgg cugggacucc      180

gaguccggca ccaucaucuu ccuccacaac ugguccaagg gcaacuucuc caacgaggag      240

cucuccgacc ucgagcuccu cuuccgcuuc uaccucuucg gccucacccg cgagauccag      300

gaccacgccu cccaggacua cuccaaguac cccuucgagg uccaggucaa ggccggcugc      360

gagcuccacu ccggcaaguc ccccgagggc uucuuccagg ucgccuucaa cggccucgac      420

cuccucuccu uccagaacac caccuggguc cccucccccg gcugcggcuc ccucgcccag      480

uccgucugcc accuccucaa ccaccaguac gagggcguca ccgagaccgu cuacaaccuc      540

auccgcucca ccugcccccg cuuccuccuc ggccuccucg acgccggcaa gauguacguc      600

caccgccagg uccgccccga ggccuggcuc uccucccgcc ccucccucgg cuccggccag      660

cuccuccucg ucugccacgc cuccggcuuc uaccccaagc ccgucugggu caccuggaug      720

cgcaacgagc aggagcagcu cggcaccaag cacggcgaca uccuccccaa cgccgacggc      780

accugguacc uccaggucau ccucgagguc gccuccgagg agcccgccgg ccucuccugc      840

cgcguccgcc acuccucccu cggcggccag gacaucaucc ucuacugggg ccaccacuuc      900

uccaugaacu ggaucgcccu cgucgucauc gucccccucg ucauccucau cguccucguc      960

cucugguuca agaagcacug cuccuaccag gacauccucu ga                        1002


<210>  780
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD1C__Homo_sapiens__AAI26466

<400>  780
augcuguucc uccaguuucu ucuguuggcc uuacugcuac ccggcgggga caacgcugau       60

gcaagccaag agcacguguc cuuccauguc auccagauau uuucuuucgu uaaucaguca      120

ugggccagag gacaggguag uggcuggcuc gacgaacugc aaacccacgg gugggauagc      180

gaguccggaa caauuaucuu ucuucauaac uggucuaagg gcaauuucuc gaacgaggaa      240

cugucagacu uggaacuccu guuuagguuc uaccuguuug gucucacucg ggagauucag      300

gaucacgcga gccaggacua uaguaaauac ccuuucgagg ugcagguaaa ggcugggugc      360

gaauuacauu ccggaaaauc uccagagggc uuuuuccaag uggccuuuaa uggccuggau      420

cuuuugagcu uccagaacac gaccuggguc ccgucccccg gguguggauc acuggcacag      480

agugugugcc accuacucaa ucaccaguau gaagguguua cagagacugu guacaaccug      540

auccgcagca ccuguccucg auuccuucug ggcuugcucg acgccgggaa gauguauguc      600

caucgucaag ugagaccaga ggcuuggcug ucuuccaggc ccucauuagg aagcggccag      660

cugcuccuug uaugccacgc aagugguuuu uacccuaaac caguuugggu gacauggaug      720

cggaaugaac aggagcaacu ggggaccaag cauggagaua uuuugcccaa cgccgacggc      780

acuugguauc uacaggucau ccuggaagug gcuucugagg aaccugccgg ccucuccugu      840

cgcgugagac acagcucgcu ugggggacag gauauaaucc uguacugggg ucaccauuuc      900

ucuaugaauu ggauugcgcu ggucguuauc gugccauugg uaauucucau cgugcugguc      960

uuaugguuua agaaacacug cuccuaccag gacauacugu ga                        1002


<210>  781
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD1C__Homo_sapiens__AAI26466

<400>  781
augcuguucc ugcaguuccu gcugcuggcc cugcugcugc ccggcggcga caacgccgac       60

gccagccagg agcacgugag cuuccacgug auccagaucu ucagcuucgu gaaccagagc      120

ugggccagag gccagggcag cggcuggcug gacgagcugc agacccacgg cugggacagc      180

gagagcggca ccaucaucuu ccugcacaac uggagcaagg gcaacuucag caacgaggag      240

cugagcgacc uggagcugcu guucagauuc uaccuguucg gccugaccag agagauccag      300

gaccacgcca gccaggacua cagcaaguac cccuucgagg ugcaggugaa ggccggcugc      360

gagcugcaca gcggcaagag ccccgagggc uucuuccagg uggccuucaa cggccuggac      420

cugcugagcu uccagaacac caccugggug cccagccccg gcugcggcag ccuggcccag      480

agcgugugcc accugcugaa ccaccaguac gagggcguga ccgagaccgu guacaaccug      540

aucagaagca ccugccccag auuccugcug ggccugcugg acgccggcaa gauguacgug      600

cacagacagg ugagacccga ggccuggcug agcagcagac ccagccuggg cagcggccag      660

cugcugcugg ugugccacgc cagcggcuuc uaccccaagc ccgugugggu gaccuggaug      720

agaaacgagc aggagcagcu gggcaccaag cacggcgaca uccugcccaa cgccgacggc      780

accugguacc ugcaggugau ccuggaggug gccagcgagg agcccgccgg ccugagcugc      840

agagugagac acagcagccu gggcggccag gacaucaucc uguacugggg ccaccacuuc      900

agcaugaacu ggaucgcccu gguggugauc gugccccugg ugauccugau cgugcuggug      960

cugugguuca agaagcacug cagcuaccag gacauccugu ga                        1002


<210>  782
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD1C__Homo_sapiens__AAI26466

<400>  782
augcuguucc uccaguuucu gcuucuggcc cuccugcuuc ccggcgggga caacgcugau       60

gccagccaag agcacguguc cuuccauguc auccagaucu uuucuuucgu uaaucagagc      120

ugggcgagag gacagggcuc cggguggcug gacgaacucc aaacccacgg augggauucu      180

gagagcggca caauuauuuu ucugcauaac ugguccaagg ggaauuucuc uaacgaggaa      240

cugagcgacc ucgaacugcu uuuucgguuc uaccuguuug gacucacgcg cgagauccag      300

gaucacgcuu cccaggacua uagcaaauac ccuuucgagg uccaggugaa ggccggcugc      360

gaacugcauu cuggcaaauc cccggagggg uuuuuccaag uggccuuuaa uggacuugau      420

cugcucagcu uccagaacac cacaugggug cccucuccug gcuguggguc ccuggcucag      480

agcguuugcc aucugcucaa ucaccaguau gaaggaguga ccgagacagu cuacaaccug      540

auuagaucua ccuguccccg guuccuucug ggccuccugg acgccgggaa gauguaugug      600

caccgccaag uuagaccuga ggcuuggcuu uccagccggc ccucccuggg aucuggccag      660

cuccugcugg ugugccacgc cagcggcuuu uacccuaaac cggucugggu gacauggaug      720

cgcaaugaac aggagcaacu cgggaccaag cauggagaua uccugcccaa cgcggacggc      780

acgugguauc uucaggugau ccuggaaguc gccuccgagg aaccugcugg gcucagcugu      840

agaguucggc acucuucccu gggaggccag gauauuaucc uuuacugggg gcaccauuuc      900

agcaugaauu ggauugcccu gguggugauc gucccccucg ugauucugau cguucuggug      960

cucugguuua agaaacacug cucuuaccag gacauucugu ga                        1002


<210>  783
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD1D__Homo_sapiens__P15813

<400>  783

Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210>  784
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD1D__Homo_sapiens__AAA59672

<400>  784
auggggugcc ugcuguuucu gcugcucugg gcgcuccucc aggcuugggg aagcgcugaa       60

gucccgcaaa ggcuuuuccc ccuccgcugc cuccagaucu cguccuucgc caauagcagc      120

uggacgcgca ccgacggcuu ggcguggcug ggggagcugc agacgcacag cuggagcaac      180

gacucggaca ccguccgcuc ucugaagccu uggucccagg gcacguucag cgaccagcag      240

ugggagacgc ugcagcauau auuucggguu uaucgaagca gcuucaccag ggacgugaag      300

gaauucgcca aaaugcuacg cuuauccuau cccuuggagc uccagguguc cgcuggcugu      360

gaggugcacc cugggaacgc cucaaauaac uucuuccaug uagcauuuca aggaaaagau      420

auccugaguu uccaaggaac uucuugggag ccaacccaag aggccccacu uuggguaaac      480

uuggccauuc aagugcucaa ccaggacaag uggacgaggg aaacagugca guggcuccuu      540

aauggcaccu gcccccaauu ugucaguggc cuccuugagu cagggaaguc ggaacugaag      600

aagcaaguga agcccaaggc cuggcugucc cguggcccca guccuggccc uggccgucug      660

cugcuggugu gccaugucuc aggauucuac ccaaagccug uaugggugaa guggaugcgg      720

ggugagcagg agcagcaggg cacucagcca ggggacaucc ugcccaaugc ugacgagaca      780

ugguaucucc gagcaacccu ggauguggug gcuggggagg cagcuggccu guccugucgg      840

gugaagcaca gcagucuaga gggccaggac aucguccucu acuggggugg gagcuacacc      900

uccaugggcu ugauugccuu ggcaguccug gcgugcuugc uguuccuccu cauugugggc      960

uuuaccuccc gguuuaagag gcaaacuucc uaucagggcg uccuguga                  1008


<210>  785
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD1D__Homo_sapiens__AAA59672

<400>  785
augggcugcc uccuguuccu gcugcucugg gcccugcugc aggccugggg gagcgcggag       60

gugccccagc gccucuuccc gcugcggugc cugcagaucu ccagcuucgc caacuccagc      120

uggacccgca ccgacggccu cgccuggcug ggggagcugc agacgcacuc cuggagcaac      180

gacuccgaca ccguccggag ccucaagccc uggucccagg gcaccuucag cgaccagcag      240

ugggagaccc ugcagcacau cuuccgcgug uaccggucca gcuucacgcg cgacgugaag      300

gaguucgcca agaugcugcg gcucuccuac ccccuggagc ugcaggucag cgccgggugc      360

gaggugcacc ccggcaacgc guccaacaac uucuuccacg uggccuucca gggcaaggac      420

auccucagcu uccaggggac cuccugggag ccgacccagg aggcgccccu gugggucaac      480

cuggccaucc aggugcucaa ccaggacaag uggacccgcg agacggugca guggcugcug      540

aacgggaccu gcccccaguu cgucagcggg cuccuggagu ccggcaagag cgagcugaag      600

aagcagguca agcccaaggc cuggcucagc cgggggccgu cccccggccc cggccgccug      660

cugcucgugu gccacgugag cggguucuac cccaagccgg ugugggugaa guggaugcgg      720

ggcgagcagg agcagcaggg gacccagccc ggcgacaucc ugcccaacgc cgacgagacc      780

ugguaccugc gcgccacgcu cgacgucgug gccggcgagg ccgcggggcu guccugccgg      840

gugaagcaca gcucccugga gggccaggac aucguccucu acuggggcgg cagcuacacc      900

uccauggggc ugaucgcccu ggccgugcuc gccugccugc uguuccuccu gaucgugggc      960

uucaccagcc gcuucaagcg gcagaccucc uaccagggcg uccuguga                  1008


<210>  786
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD1D__Homo_sapiens__AAA59672

<400>  786
augggcugcc uccucuuccu ccuccucugg gcccuccucc aggccugggg cuccgccgag       60

gucccccagc gccucuuccc ccuccgcugc cuccagaucu ccuccuucgc caacuccucc      120

uggacccgca ccgacggccu cgccuggcuc ggcgagcucc agacccacuc cugguccaac      180

gacuccgaca ccguccgcuc ccucaagccc uggucccagg gcaccuucuc cgaccagcag      240

ugggagaccc uccagcacau cuuccgcguc uaccgcuccu ccuucacccg cgacgucaag      300

gaguucgcca agaugcuccg ccucuccuac ccccucgagc uccaggucuc cgccggcugc      360

gagguccacc ccggcaacgc cuccaacaac uucuuccacg ucgccuucca gggcaaggac      420

auccucuccu uccagggcac cuccugggag cccacccagg aggccccccu cugggucaac      480

cucgccaucc agguccucaa ccaggacaag uggacccgcg agaccgucca guggcuccuc      540

aacggcaccu gcccccaguu cgucuccggc cuccucgagu ccggcaaguc cgagcucaag      600

aagcagguca agcccaaggc cuggcucucc cgcggccccu cccccggccc cggccgccuc      660

cuccucgucu gccacgucuc cggcuucuac cccaagcccg ucugggucaa guggaugcgc      720

ggcgagcagg agcagcaggg cacccagccc ggcgacaucc uccccaacgc cgacgagacc      780

ugguaccucc gcgccacccu cgacgucguc gccggcgagg ccgccggccu cuccugccgc      840

gucaagcacu ccucccucga gggccaggac aucguccucu acuggggcgg cuccuacacc      900

uccaugggcc ucaucgcccu cgccguccuc gccugccucc ucuuccuccu caucgucggc      960

uucaccuccc gcuucaagcg ccagaccucc uaccagggcg uccucuga                  1008


<210>  787
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD1D__Homo_sapiens__AAA59672

<400>  787
augggcugcc uccuguuccu ucuguugugg gccuuacugc aggcuugggg gagcgcagag       60

gugccccaaa gacuauuucc ucucaggugu cugcagaucu ccucuuucgc caacucaagu      120

uggacccgga cagacggacu ugcguggcug ggugaauugc agacucacag cugguccaau      180

gauucugaca cgguccgcuc gcucaagcca uggucacagg gcaccuuuag cgaucaacag      240

ugggagacac ugcagcauau uuuccgaguu uaccguaguu ccuuuacuag agacgugaaa      300

gaguucgcua agaugcugag gcucucuuau ccguuagaac ugcagguaag cgccgggugc      360

gaagugcacc ccggaaacgc auccaauaac uuuuuccaug ucgccuuuca aggcaaagau      420

auacuuucau uccaggguac caguugggag ccuacacagg aggcuccauu gugggugaau      480

cuggcaaucc agguucuaaa ccaagacaag uggacccggg aaacugugca guggcuccug      540

aaugggacau guccccaguu ugucagcgga cuucuggagu cuggcaaauc cgaauugaag      600

aagcaaguga aaccuaaggc cuggcucuca cgcggcccaa gccccgggcc uggaagacug      660

uuacugguau gccacguuag ugguuucuac ccaaaaccgg ugugggucaa guggaugagg      720

ggcgagcagg agcagcaggg gacccaaccc ggagauauuc ucccuaacgc ugacgaaacg      780

ugguaucuuc gggccacucu ggauguggug gcgggcgagg cagccgguuu gucuugucgc      840

gucaaacauu ccagccuaga agggcaggac aucguucugu acuggggagg cucguauacc      900

ucuaugggcc ucauugcucu ggccgugcuu gcaugccugu uguuucuccu gaucguaggg      960

uucacauccc gauucaagag acagacuuca uaccagggag uguuauga                  1008


<210>  788
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD1D__Homo_sapiens__AAA59672

<400>  788
augggcugcc ugcuguuccu gcugcugugg gcccugcugc aggccugggg cagcgccgag       60

gugccccaga gacuguuccc ccugagaugc cugcagauca gcagcuucgc caacagcagc      120

uggaccagaa ccgacggccu ggccuggcug ggcgagcugc agacccacag cuggagcaac      180

gacagcgaca ccgugagaag ccugaagccc uggagccagg gcaccuucag cgaccagcag      240

ugggagaccc ugcagcacau cuucagagug uacagaagca gcuucaccag agacgugaag      300

gaguucgcca agaugcugag acugagcuac ccccuggagc ugcaggugag cgccggcugc      360

gaggugcacc ccggcaacgc cagcaacaac uucuuccacg uggccuucca gggcaaggac      420

auccugagcu uccagggcac cagcugggag cccacccagg aggccccccu gugggugaac      480

cuggccaucc aggugcugaa ccaggacaag uggaccagag agaccgugca guggcugcug      540

aacggcaccu gcccccaguu cgugagcggc cugcuggaga gcggcaagag cgagcugaag      600

aagcagguga agcccaaggc cuggcugagc agaggcccca gccccggccc cggcagacug      660

cugcuggugu gccacgugag cggcuucuac cccaagcccg ugugggugaa guggaugaga      720

ggcgagcagg agcagcaggg cacccagccc ggcgacaucc ugcccaacgc cgacgagacc      780

ugguaccuga gagccacccu ggacguggug gccggcgagg ccgccggccu gagcugcaga      840

gugaagcaca gcagccugga gggccaggac aucgugcugu acuggggcgg cagcuacacc      900

agcaugggcc ugaucgcccu ggccgugcug gccugccugc uguuccugcu gaucgugggc      960

uucaccagca gauucaagag acagaccagc uaccagggcg ugcuguga                  1008


<210>  789
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD1D__Homo_sapiens__AAA59672

<400>  789
augggcugcc uccuguuccu gcuucugugg gcccuccugc aggcuugggg gagcgccgag       60

gugccccaaa gacuuuuucc ucugcggugu cuccagaucu ccucuuucgc gaacagcucc      120

uggacccgca cagacggacu ggcuuggcug ggcgaacucc agacgcacuc uuggagcaau      180

gauuccgaca ccgucagauc ucugaagccg uggagccagg ggacauuuuc cgaucaacag      240

ugggagaccc uucagcauau uuuccggguu uaccgcagcu cuuuuacaag agacgugaaa      300

gaguucgcca agaugcugcg gcucuccuau ccccuggaac uucaggugag cgccggaugc      360

gaaguccacc cuggcaacgc uucuaauaac uuuuuccaug uggccuuuca agggaaagau      420

auccuguccu uccagggaac cagcugggag cccacacagg aggcuccucu cuggguuaau      480

cuggccauuc aggugcugaa ccaagacaag uggacccgcg aaacggucca guggcuccug      540

aauggcaccu guccccaguu ugugucuggc cuucuggagu ccgggaaaag cgaacucaag      600

aagcaaguua aaccuaaggc guggcugucc agaggaccgu cucccggccc ugggcggcuu      660

cugcucgugu gccacgucag cggauucuac cccaaaccug ugugggugaa guggaugcgc      720

ggcgagcagg agcagcaggg gacacaaccc ggagauaucc ugccgaacgc cgacgaaacc      780

ugguaucuga gagcuacacu cgaugucguu gccggcgagg cugccggccu guccugucgg      840

gugaaacaua gcucucuuga agggcaggac auugugcugu acuggggagg cuccuauacc      900

agcauggggc ucaucgcgcu ggccguccuu gcuugccugc ucuuucugcu gaucguggga      960

uucacgucuc gcuucaagag acagacaagc uaccagggcg uucucuga                  1008


<210>  790
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD1E__Homo_sapiens__P15812

<400>  790

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210>  791
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD1E__Homo_sapiens__EAW52830

<400>  791
augcugcucc uguuccuccu cuucgagggu cucugcuguc cuggggaaaa uacagcagcu       60

ccccaggcuc uacaauccua ucaucuagca gcagaggagc agcuguccuu ccgcaugcuc      120

caaacuuccu ccuuugccaa ccacagcugg gcacacagug agggcucagg auggcugggu      180

gaccugcaga cucauggcug ggacacuguc uugggcacca uccgcuuucu gaagcccugg      240

ucccauggaa acuucagcaa gcaggagcug aaaaacuuac agucacuguu ccaguuauac      300

uuccauaguu uuauccagau agugcaagcu ucugcugguc aauuucagcu ugaauacccc      360

uucgagaucc agauauuagc uggcuguaga augaaugccc cacaaaucuu cuuaaauaug      420

gcauaucaag ggucagauuu ccugaguuuc caaggaauuu ccugggagcc aucuccagga      480

gcagggaucc gggcccagaa caucuguaaa gugcucaauc gcuaccuaga uauuaaggaa      540

auacugcaaa gccuucuugg ucacaccugc ccucgauuuc uagcggggcu cauggaagca      600

ggggagucag aacugaaacg gaaagugaag ccagaggccu ggcuguccug uggccccagu      660

ccuggcccug gccgucugca gcuugugugc caugucucag gauucuaccc aaagcccgug      720

ugggugaugu ggaugcgggg ugagcaggag cagcggggca cucagcgagg ggacguccug      780

ccuaaugcug acgagacaug guaucuccga gcaacccugg auguggcggc uggggaggca      840

gcuggccugu ccugucgggu gaaacacagc agucuagggg gccaugaucu aaucauccau      900

ugggguggau auuccaucuu ucucauccug aucuguuuga cugugauagu uacccugguc      960

auauugguug uaguugacuc acgguuaaaa aaacagaguu caaauaagaa cauucuuucu     1020

ccccacacac ccagcccugu cuuucucaug ggagccaaca cucaggacac caagaauuca     1080

agacaucagu ucugcuuggc acaaguaucg uggaucaaaa acagaguauu gaagaagugg     1140

aagacacgcc uaaaccaacu cugguga                                         1167


<210>  792
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD1E__Homo_sapiens__EAW52830

<400>  792
augcugcucc uguuccuccu guucgagggc cugugcugcc ccggggagaa caccgccgcc       60

ccgcaggcgc ugcagagcua ccaccucgcc gccgaggagc agcuguccuu ccgcaugcug      120

cagaccagcu ccuucgccaa ccacagcugg gcccacuccg agggcagcgg guggcucggc      180

gaccugcaga cgcacgggug ggacaccgug cugggcacca uccgguuccu caagcccugg      240

ucccacggca acuucagcaa gcaggagcug aagaaccugc agucccucuu ccagcuguac      300

uuccacagcu ucauccagau cguccaggcg uccgccgggc aguuccagcu ggaguacccc      360

uucgagaucc agauccucgc cggcugccgc augaacgcgc cccagaucuu ccugaacaug      420

gccuaccagg ggagcgacuu ccuguccuuc cagggcauca gcugggagcc gucccccggg      480

gccggcaucc gggcccagaa caucugcaag gugcucaacc gcuaccugga caucaaggag      540

auccugcaga gccuccuggg ccacacgugc ccccgguucc uggccgggcu cauggaggcc      600

ggcgaguccg agcugaagcg caaggugaag cccgaggcgu ggcugagcug cgggccgucc      660

cccggccccg gccggcucca gcuggucugc cacgugagcg gguucuaccc caagccggug      720

ugggucaugu ggaugcgcgg cgagcaggag cagcggggga cccagcgcgg cgacgugcug      780

cccaacgccg acgagaccug guaccuccgg gccacccugg acguggccgc cggggaggcg      840

gccggccuga gcugccgcgu caagcacucc agccucggcg ggcacgaccu gaucauccac      900

uggggcgggu acuccaucuu ccugauccuc aucugccuga ccgugaucgu gacgcugguc      960

auccucgugg uggucgacag ccggcugaag aagcagucca gcaacaagaa cauccugagc     1020

ccccacaccc ccuccccggu guuccucaug ggcgccaaca cccaggacac caagaacucc     1080

cgccaccagu ucugccuggc ccaggugagc uggaucaaga accggguccu gaagaagugg     1140

aagacgcgcc ucaaccagcu gugguga                                         1167


<210>  793
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD1E__Homo_sapiens__EAW52830

<400>  793
augcuccucc ucuuccuccu cuucgagggc cucugcugcc ccggcgagaa caccgccgcc       60

ccccaggccc uccaguccua ccaccucgcc gccgaggagc agcucuccuu ccgcaugcuc      120

cagaccuccu ccuucgccaa ccacuccugg gcccacuccg agggcuccgg cuggcucggc      180

gaccuccaga cccacggcug ggacaccguc cucggcacca uccgcuuccu caagcccugg      240

ucccacggca acuucuccaa gcaggagcuc aagaaccucc agucccucuu ccagcucuac      300

uuccacuccu ucauccagau cguccaggcc uccgccggcc aguuccagcu cgaguacccc      360

uucgagaucc agauccucgc cggcugccgc augaacgccc cccagaucuu ccucaacaug      420

gccuaccagg gcuccgacuu ccucuccuuc cagggcaucu ccugggagcc cucccccggc      480

gccggcaucc gcgcccagaa caucugcaag guccucaacc gcuaccucga caucaaggag      540

auccuccagu cccuccucgg ccacaccugc ccccgcuucc ucgccggccu cauggaggcc      600

ggcgaguccg agcucaagcg caaggucaag cccgaggccu ggcucuccug cggccccucc      660

cccggccccg gccgccucca gcucgucugc cacgucuccg gcuucuaccc caagcccguc      720

ugggucaugu ggaugcgcgg cgagcaggag cagcgcggca cccagcgcgg cgacguccuc      780

cccaacgccg acgagaccug guaccuccgc gccacccucg acgucgccgc cggcgaggcc      840

gccggccucu ccugccgcgu caagcacucc ucccucggcg gccacgaccu caucauccac      900

uggggcggcu acuccaucuu ccucauccuc aucugccuca ccgucaucgu cacccucguc      960

auccucgucg ucgucgacuc ccgccucaag aagcaguccu ccaacaagaa cauccucucc     1020

ccccacaccc ccucccccgu cuuccucaug ggcgccaaca cccaggacac caagaacucc     1080

cgccaccagu ucugccucgc ccaggucucc uggaucaaga accgcguccu caagaagugg     1140

aagacccgcc ucaaccagcu cugguga                                         1167


<210>  794
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD1E__Homo_sapiens__EAW52830

<400>  794
augcugcucc uuuuccuguu guuugagggc uuaugcuguc ccggggaaaa caccgccgcu       60

ccucaggcac ugcaaagcua ccaccuagcc gcggaggaac agcucuccuu cagaaugcug      120

cagacaucuu cauuugcuaa ucauaguugg gcccacagcg agggauccgg uuggcuuggc      180

gaccugcaga cucaugggug ggauacggug uugggaacca ucagguuccu caagccaugg      240

ucucacggca acuuuucgaa acaagaacug aagaaucugc agucacucuu ccaguuauau      300

uuucauagcu ucauucagau aguccaagca agugccgguc aguuucagcu ggaguacccg      360

uucgagaucc agauucuugc ugggugccgg augaacgcac cccaaaucuu uuugaauaug      420

gccuaucagg gauccgacuu ccugucuuuu cagggcauua gcugggaacc uuccccaggc      480

gcugggaucc gcgcccaaaa cauauguaaa guucuaaauc gauaccucga uaucaaggag      540

auucugcagu cacuucuggg acacacaugc ccccguuucu uggcgggucu cauggaagca      600

ggcgagagug agcugaaaag aaaggugaag ccugaagccu gguuaagcug ugggccaucu      660

cccggaccug gcaggcugca gcucguaugc cacguguccg guuucuaucc aaaaccgguc      720

ugggugaugu ggaugcgcgg ggagcaggaa caacggggaa cucagagagg cgacguucuu      780

cccaacgcug augagaccug guaccugagg gccacauugg acguggcagc uggcgaagcc      840

gcggggcuau caugucgggu caagcauagc agucugggag gucacgaucu caucauucau      900

uggggcgggu auucuaucuu ucugauacuu auuugccuga ccgugaucgu aacuuugguu      960

auucucgugg ucguggacuc ccgccugaaa aagcagagcu cgaauaaaaa caucuuaucu     1020

ccucacacac caucccccgu guuccugaug ggagccaaua cccaggauac gaagaacuca     1080

cgacaccaau uuugucuagc acaggucagu uggaucaaga auagaguucu caaaaagugg     1140

aaaacuaggc ugaaccagcu uugguga                                         1167


<210>  795
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD1E__Homo_sapiens__EAW52830

<400>  795
augcugcugc uguuccugcu guucgagggc cugugcugcc ccggcgagaa caccgccgcc       60

ccccaggccc ugcagagcua ccaccuggcc gccgaggagc agcugagcuu cagaaugcug      120

cagaccagca gcuucgccaa ccacagcugg gcccacagcg agggcagcgg cuggcugggc      180

gaccugcaga cccacggcug ggacaccgug cugggcacca ucagauuccu gaagcccugg      240

agccacggca acuucagcaa gcaggagcug aagaaccugc agagccuguu ccagcuguac      300

uuccacagcu ucauccagau cgugcaggcc agcgccggcc aguuccagcu ggaguacccc      360

uucgagaucc agauccuggc cggcugcaga augaacgccc cccagaucuu ccugaacaug      420

gccuaccagg gcagcgacuu ccugagcuuc cagggcauca gcugggagcc cagccccggc      480

gccggcauca gagcccagaa caucugcaag gugcugaaca gauaccugga caucaaggag      540

auccugcaga gccugcuggg ccacaccugc cccagauucc uggccggccu gauggaggcc      600

ggcgagagcg agcugaagag aaaggugaag cccgaggccu ggcugagcug cggccccagc      660

cccggccccg gcagacugca gcuggugugc cacgugagcg gcuucuaccc caagcccgug      720

ugggugaugu ggaugagagg cgagcaggag cagagaggca cccagagagg cgacgugcug      780

cccaacgccg acgagaccug guaccugaga gccacccugg acguggccgc cggcgaggcc      840

gccggccuga gcugcagagu gaagcacagc agccugggcg gccacgaccu gaucauccac      900

uggggcggcu acagcaucuu ccugauccug aucugccuga ccgugaucgu gacccuggug      960

auccuggugg ugguggacag cagacugaag aagcagagca gcaacaagaa cauccugagc     1020

ccccacaccc ccagccccgu guuccugaug ggcgccaaca cccaggacac caagaacagc     1080

agacaccagu ucugccuggc ccaggugagc uggaucaaga acagagugcu gaagaagugg     1140

aagaccagac ugaaccagcu gugguga                                         1167


<210>  796
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD1E__Homo_sapiens__EAW52830

<400>  796
augcugcucc uguuccuucu guuugagggc cucugcuguc ccggggaaaa caccgccgcu       60

ccucaggccc ugcaaagcua ccaccuugcg gcugaggaac agcuguccuu cagaaugcuc      120

cagacaucua gcuuugccaa ucauuccugg gcccacucug agggaagcgg cuggcugggg      180

gaccugcaga cgcauggaug ggauaccgug cucggcacaa uccgguuccu gaagccgugg      240

ucccacggga acuuuucuaa acaagaacuu aagaaucugc agagccucuu ccagcuguau      300

uuucauuccu ucauucagau cguccaagcu agcgccggac aguuucagcu ugaguacccc      360

uucgagauuc agauccuggc uggcugccgc augaacgccc cucaaauuuu ucucaauaug      420

gcguaucagg gcucugacuu ccuguccuuu caggggauca gcugggaacc cucuccugga      480

gccggcauca gagcucaaaa cauuuguaaa guucugaauc gguaccucga uaucaaggag      540

auucugcagu cccuucuggg gcauaccugc ccccgcuucc ucgccggacu gauggaagcu      600

ggcgagagcg agcuuaaaag aaaggugaag ccugaagccu ggcugucuug ugggccgucc      660

cccggaccug gccggcucca gcuggugugc cacgucagcg gcuucuaucc caaaccugug      720

uggguuaugu ggaugcgcgg ggagcaggaa caaagaggaa cacagcgggg cgacgugcug      780

cccaacgcgg augagaccug guaccuccgc gccacacugg acgucgcugc cggggaagcu      840

gccggacuuu ccuguagagu gaagcacucu agccugggcg ggcacgaucu caucauucau      900

uggggaggcu auuccaucuu ucugauucuu aucugccuga ccguuaucgu gacgcucguc      960

auucuggugg uggucgacag ccggcugaaa aagcagucuu ccaauaaaaa cauccucagc     1020

ccgcacaccc cuucucccgu uuuccugaug ggcgccaaua cacaggauac caagaacagc     1080

cgccaccaau uuugucuugc ucaggugucc uggauuaaga auagagugcu gaaaaagugg     1140

aaaacacggc ucaaccagcu gugguga                                         1167


<210>  797
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD20__Homo_sapiens__P11836

<400>  797

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  798
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD20__Homo_sapiens__AAA35581

<400>  798
augacaacac ccagaaauuc aguaaauggg acuuucccgg cagagccaau gaaaggcccu       60

auugcuaugc aaucuggucc aaaaccacuc uucaggagga ugucuucacu ggugggcccc      120

acgcaaagcu ucuucaugag ggaaucuaag acuuuggggg cuguccagau uaugaauggg      180

cucuuccaca uugcccuggg gggucuucug augaucccag cagggaucua ugcacccauc      240

ugugugacug ugugguaccc ucucugggga ggcauuaugu auauuauuuc cggaucacuc      300

uuggcagcaa cggagaaaaa cucuaggaag uguuugguca aaggaaaaau gauaaugaau      360

ucauugagcc ucuuugcugc cauuucugga augauucuuu caaucaugga cauacuuaau      420

auuaaaauuu cccauuuuuu aaaaauggag agucugaauu uuauuagagc ucacacacca      480

uauauuaaca uauacaacug ugaaccagcu aaucccucug agaaaaacuc cccaucuacc      540

caauacuguu acagcauaca aucucuguuc uugggcauuu ugucagugau gcugaucuuu      600

gccuucuucc aggaacuugu aauagcuggc aucguugaga augaauggaa aagaacgugc      660

uccagaccca aaucuaacau aguucuccug ucagcagaag aaaaaaaaga acagacuauu      720

gaaauaaaag aagaaguggu ugggcuaacu gaaacaucuu cccaaccaaa gaaugaagaa      780

gacauugaaa uuauuccaau ccaagaagag gaagaagaag aaacagagac gaacuuucca      840

gaaccucccc aagaucagga auccucacca auagaaaaug acagcucucc uuaa            894


<210>  799
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD20__Homo_sapiens__AAA35581

<400>  799
augaccacgc cccgcaacag cgugaacggc accuucccgg ccgagcccau gaaggggccc       60

aucgccaugc aguccggccc caagccgcug uuccggcgca ugagcucccu cgucgggccc      120

acccagagcu ucuucaugcg ggaguccaag acccugggcg cggugcagau caugaacggg      180

cuguuccaca ucgcccucgg cggccugcug augauccccg ccgggaucua cgcccccauc      240

ugcgugaccg ucugguaccc gcucuggggc gggaucaugu acaucaucag cggcucccug      300

cuggccgcga cggagaagaa cagccgcaag ugccucguga aggggaagau gaucaugaac      360

ucccugagcc uguucgccgc caucuccggc augauccuca gcaucaugga cauccugaac      420

aucaagaucu cccacuuccu gaagauggag agccucaacu ucauccgggc ccacaccccc      480

uacaucaaca ucuacaacug cgagcccgcg aaccccuccg agaagaacag cccguccacc      540

caguacugcu acagcaucca gucccuguuc cugggcaucc ucagcgugau gcugaucuuc      600

gccuucuucc aggagcuggu caucgccggg aucguggaga acgaguggaa gcggaccugc      660

agccgcccca aguccaacau cgugcuccug agcgccgagg agaagaagga gcagacgauc      720

gagaucaagg aggaggucgu gggccugacc gagaccucca gccagcccaa gaacgaggag      780

gacaucgaga ucauccccau ccaggaggag gaggaggagg agaccgagac gaacuucccg      840

gagccgcccc aggaccagga guccagcccc aucgagaacg acuccagccc cuga            894


<210>  800
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD20__Homo_sapiens__AAA35581

<400>  800
augaccaccc cccgcaacuc cgucaacggc accuuccccg ccgagcccau gaagggcccc       60

aucgccaugc aguccggccc caagccccuc uuccgccgca uguccucccu cgucggcccc      120

acccaguccu ucuucaugcg cgaguccaag acccucggcg ccguccagau caugaacggc      180

cucuuccaca ucgcccucgg cggccuccuc augauccccg ccggcaucua cgcccccauc      240

ugcgucaccg ucugguaccc ccucuggggc ggcaucaugu acaucaucuc cggcucccuc      300

cucgccgcca ccgagaagaa cucccgcaag ugccucguca agggcaagau gaucaugaac      360

ucccucuccc ucuucgccgc caucuccggc augauccucu ccaucaugga cauccucaac      420

aucaagaucu cccacuuccu caagauggag ucccucaacu ucauccgcgc ccacaccccc      480

uacaucaaca ucuacaacug cgagcccgcc aaccccuccg agaagaacuc ccccuccacc      540

caguacugcu acuccaucca gucccucuuc cucggcaucc ucuccgucau gcucaucuuc      600

gccuucuucc aggagcucgu caucgccggc aucgucgaga acgaguggaa gcgcaccugc      660

ucccgcccca aguccaacau cguccuccuc uccgccgagg agaagaagga gcagaccauc      720

gagaucaagg aggaggucgu cggccucacc gagaccuccu cccagcccaa gaacgaggag      780

gacaucgaga ucauccccau ccaggaggag gaggaggagg agaccgagac caacuucccc      840

gagccccccc aggaccagga guccuccccc aucgagaacg acuccucccc cuga            894


<210>  801
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD20__Homo_sapiens__AAA35581

<400>  801
augaccacac ccagaaacag cgugaauggc acuuucccug ccgagccaau gaaggggccg       60

aucgcuaugc aguccggacc caaaccucug uuuaggcgga ugucuucacu cgucggucca      120

acgcaaaguu ucuuuaugcg cgaaagcaag acccuuggcg caguucagau uaugaacggg      180

cuguuccaca uagccuuggg aggcuuacug augauccccg cggguauuua cgcuccuauc      240

ugcgugacag uaugguaucc acuaugggga ggaauuaugu acaucauauc cggcucucuc      300

cuggccgcaa cugagaaaaa uucgcgaaag ugucuuguga aaggcaagau gaucaugaac      360

ucacugagcu uguuugccgc uauuaguggg augauccucu ccauuaugga cauccugaau      420

auaaagauuu cucauuuccu gaaaauggaa agccucaacu uuauccgugc acacaccccc      480

uauauuaaua ucuacaacug cgagccugcc aauccauccg aaaagaacuc accgaguaca      540

caguauuguu acagcaucca gucuuuauuc cuggggauuc uuuccgucau guugauauuu      600

gcuuucuuuc aagagcuggu gaucgccggu auuguugaga augaauggaa aagaaccugc      660

ucaaggccca agagcaacau cgugcuacuc agugcggagg agaaaaagga acagacuaua      720

gagauuaagg aagaggucgu gggccugaca gaaaccucuu cccagccuaa aaaugaggaa      780

gauaucgaga ucauuccaau ccaggaggaa gaggaagagg aaacggagac uaacuucccc      840

gagccuccac aagaccagga aagcucgccc auugagaaug auucuucccc guga            894


<210>  802
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD20__Homo_sapiens__AAA35581

<400>  802
augaccaccc ccagaaacag cgugaacggc accuuccccg ccgagcccau gaagggcccc       60

aucgccaugc agagcggccc caagccccug uucagaagaa ugagcagccu ggugggcccc      120

acccagagcu ucuucaugag agagagcaag acccugggcg ccgugcagau caugaacggc      180

cuguuccaca ucgcccuggg cggccugcug augauccccg ccggcaucua cgcccccauc      240

ugcgugaccg ugugguaccc ccuguggggc ggcaucaugu acaucaucag cggcagccug      300

cuggccgcca ccgagaagaa cagcagaaag ugccugguga agggcaagau gaucaugaac      360

agccugagcc uguucgccgc caucagcggc augauccuga gcaucaugga cauccugaac      420

aucaagauca gccacuuccu gaagauggag agccugaacu ucaucagagc ccacaccccc      480

uacaucaaca ucuacaacug cgagcccgcc aaccccagcg agaagaacag ccccagcacc      540

caguacugcu acagcaucca gagccuguuc cugggcaucc ugagcgugau gcugaucuuc      600

gccuucuucc aggagcuggu gaucgccggc aucguggaga acgaguggaa gagaaccugc      660

agcagaccca agagcaacau cgugcugcug agcgccgagg agaagaagga gcagaccauc      720

gagaucaagg aggagguggu gggccugacc gagaccagca gccagcccaa gaacgaggag      780

gacaucgaga ucauccccau ccaggaggag gaggaggagg agaccgagac caacuucccc      840

gagccccccc aggaccagga gagcagcccc aucgagaacg acagcagccc cuga            894


<210>  803
<211>  894
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD20__Homo_sapiens__AAA35581

<400>  803
augaccacac ccagaaacag cgugaauggc acguucccug ccgagccgau gaaggggccc       60

aucgcuaugc aguccggacc uaaaccccug uuucggcgca ugucuagccu cgucggcccu      120

acccaauccu ucuuuaugag agaaucuaag acacuggggg ccguucagau uaugaacgga      180

cuuuuccaca ucgcgcuggg cgggcuccug augauucccg cuggaaucua cgccccuauu      240

ugcgugaccg ugugguaucc gcuuuggggc ggcaucaugu acaucauuag cgggucccug      300

cucgccgcua cagagaaaaa uucucggaag ugucugguca aaggaaagau gaucaugaac      360

agccuguccc ucuuugccgc uauuagcggc augauccugu cuauuaugga cauccuuaau      420

auuaagaucu cccauuuccu gaaaauggaa agccucaacu uuauccgcgc ccacaccccc      480

uauauuaaua ucuacaacug cgagccugcg aaucccucug aaaagaacuc cccuagcaca      540

caguauuguu acucuauuca gucccuguuc cuugggaucc ugagcgugau gcucauuuuu      600

gccuucuuuc aagagcuggu uaucgcugga aucguggaga augaauggaa aagaaccugc      660

ucccggccca agucuaacau uguccugcuc agcgccgagg agaaaaagga acagacgauc      720

gagauuaagg aagagguggu uggccugacc gaaacaucca gccagccgaa aaaugaggaa      780

gauaucgaga uuaucccuau ccaggaggaa gaggaagagg aaaccgagac aaacuucccc      840

gagccucccc aagaccagga aucuuccccc auugagaaug auagcucucc uuga            894


<210>  804
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__O60926

<400>  804

Met Glu Ser Lys Thr Glu Lys Trp Met Glu Arg Ile His Leu Asn Val 
1               5                   10                  15      


Ser Glu Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln 
            20                  25                  30          


Glu Ser Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr 
        35                  40                  45              


Gly Tyr Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg 
    50                  55                  60                  


Gln Ala Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr 
65                  70                  75                  80  


Arg Ser Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile 
                85                  90                  95      


Val Thr Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp 
            100                 105                 110         


Thr Val Gln Leu Asn Val Lys His Thr Pro Lys Leu Glu Ile Lys Val 
        115                 120                 125             


Thr Pro Ser Asp Ala Ile Val Arg Glu Gly Asp Ser Val Thr Met Thr 
    130                 135                 140                 


Cys Glu Val Ser Ser Thr Asn Pro Glu Tyr Thr Thr Val Ser Trp Leu 
145                 150                 155                 160 


Lys Asp Gly Thr Ser Leu Lys Lys Gln Asn Thr Phe Thr Leu Asn Leu 
                165                 170                 175     


Arg Glu Val Thr Lys Asp Gln Ser Gly Lys Tyr Cys Cys Gln Val Ser 
            180                 185                 190         


Asn Asp Val Gly Pro Gly Arg Ser Glu Glu Val Phe Leu Gln Val Gln 
        195                 200                 205             


Tyr Ala Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val 
    210                 215                 220                 


Glu Gly Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu 
225                 230                 235                 240 


Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg 
                245                 250                 255     


Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly 
            260                 265                 270         


Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr 
    290                 295                 300                 


Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 
305                 310                 315                 320 


Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp 
                325                 330                 335     


Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile 
            340                 345                 350         


Gln Lys Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Arg Cys Asn 
        355                 360                 365             


Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala 
    370                 375                 380                 


Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
385                 390                 395                 400 


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
                405                 410                 415     


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
            420                 425                 430         


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
        435                 440                 445             


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
    450                 455                 460                 


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
465                 470                 475                 480 


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Arg Cys 
                485                 490                 495     


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
            500                 505                 510         


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
        515                 520                 525             


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
    530                 535                 540                 


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
545                 550                 555                 560 


Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu 
                565                 570                 575     


Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Asp 
            580                 585                 590         


Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Arg Thr Cys Asp Asp Thr 
        595                 600                 605             


Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu Asn 
    610                 615                 620                 


Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu Leu 
625                 630                 635                 640 


Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val Asp 
                645                 650                 655     


Tyr Val Ile Leu Lys His 
            660         


<210>  805
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__AAC18956

<400>  805
auggagucca agacugagaa auggauggaa cgaauacacc ucaaugucuc ugaaaggccu       60

uuuccaccuc auauccagcu cccuccagaa auucaagagu cccaggaagu cacucugacc      120

ugcuugcuga auuucuccug cuauggguau ccgauccaau ugcaguggcu ccuagagggg      180

guuccaauga ggcaggcugc ugucaccucg accuccuuga ccaucaaguc ugucuucacc      240

cggagcgagc ucaaguucuc cccacagugg agucaccaug ggaagauugu gaccugccag      300

cuucaggaug cagaugggaa guuccucucc aaugacacgg ugcagcugaa cgugaagcac      360

accccgaagu uggagaucaa ggucacuccc agugaugcca uagugaggga gggggacucu      420

gugaccauga ccugcgaggu cagcagcacg aacccggagu acacgacggu auccuggcuc      480

aaggauggga ccucgcugaa gaagcagaau acauucacgc uaaaccugcg cgaagugacc      540

aaggaccaga gugggaagua cugcugucag gucuccaaug acgugggccc gggaaggucg      600

gaagaagugu uccugcaagu gcaguaugcc ccggaaccuu ccacgguuca gauccuccac      660

ucaccggcug uggagggaag ucaagucgag uuucuuugca ugucacuggc caauccucuu      720

ccaacaaauu acacguggua ccacaauggg aaagaaaugc agggaaggac agaggagaaa      780

guccacaucc caaagauccu ccccuggcac gcugggacuu auuccugugu ggcagaaaac      840

auucuuggua cuggacagag gggcccggga gcugagcugg auguccagua uccucccaag      900

aaggugacca cagugauuca aaaccccaug ccgauucgag aaggagacac agugacccuu      960

uccuguaacu acaauuccag uaaccccagu guuacccggu augaauggaa accccauggc     1020

gccugggagg agccaucgcu uggggugcug aagauccaaa agguuggcug ggacaacaca     1080

accaucgccu gcgcacguug uaauaguugg ugcucguggg ccuccccugu cgcccugaau     1140

guccaguaug ccccccgaga cgugaggguc cggaaaauca agccccuuuc cgagauucac     1200

ucuggaaacu cggucagccu ccaaugugac uucucaagca gccaccccaa agaaguccag     1260

uucuucuggg agaaaaaugg caggcuucug gggaaagaaa gccagcugaa uuuugacucc     1320

aucuccccag aagaugcugg gaguuacagc ugcuggguga acaacuccau aggacagaca     1380

gcguccaagg ccuggacacu ugaagugcug uaugcaccca ggaggcugcg uguguccaug     1440

agcccggggg accaagugau ggaggggaag agugcaaccc ugagguguga gagcgacgcc     1500

aacccucccg ucucccacua caccugguuu gacuggaaua accaaagccu ccccuaccac     1560

agccagaagc ugagauugga gccggugaag guccagcacu cgggugccua cuggugccag     1620

gggaccaaca gugugggcaa gggccguucg ccucucagca cccucaccgu cuacuauagc     1680

ccggagacca ucggcaggcg aguggcugug ggacucgggu ccugccucgc cauccucauc     1740

cuggcaaucu gugggcucaa gcuccagcga cgagaugcag aguccucaga gaugcagaga     1800

ccuccccgga ccugcgauga cacggucacu uauucagcau ugcacaagcg ccaagugggc     1860

gacuaugaga acgucauucc agauuuucca gaagaugagg ggauucauua cucagagcug     1920

auccaguuug gggucgggga gcggccucag gcacaagaaa auguggacua ugugauccuc     1980

aaacauuga                                                             1989


<210>  806
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD22__Homo_sapiens__AAC18956

<400>  806
auggagagca agaccgagaa guggauggag cgcauccacc ugaacguguc cgagcggccc       60

uucccgcccc acauccagcu cccgcccgag auccaggaga gccaggaggu cacccugacg      120

ugccugcuca acuucuccug cuacggcuac cccauccagc ugcaguggcu gcucgagggg      180

gugcccaugc gccaggccgc cgugaccagc accucccuga ccaucaagag cgucuucacg      240

cgguccgagc ugaaguucag cccccagugg ucccaccacg gcaagaucgu gaccugccag      300

cuccaggacg cggacgggaa guuccugagc aacgacaccg ugcagcugaa cgucaagcac      360

acccccaagc ucgagaucaa ggugacgccg uccgacgcca ucgugcgcga gggcgacagc      420

gucaccauga ccugcgaggu guccagcacc aaccccgagu acacgaccgu guccuggcug      480

aaggacggga ccagccugaa gaagcagaac accuucacgc ucaaccugcg ggaggucacc      540

aaggaccagu ccggcaagua cugcugccag gugagcaacg acgugggccc cgggcgcucc      600

gaggaggucu uccuccaggu gcaguacgcc cccgagccga gcaccgugca gauccugcac      660

agccccgccg ucgagggcuc ccagguggag uuccugugca ugagccuggc caacccccuc      720

cccaccaacu acacguggua ccacaacggg aaggagaugc agggccggac cgaggagaag      780

gugcacaucc cgaagauccu gcccuggcac gcggggaccu acuccugcgu cgccgagaac      840

auccugggca ccggccagcg cgggcccggc gccgagcucg acgugcagua cccgcccaag      900

aaggugacga ccgucaucca gaaccccaug cccauccggg agggggacac cgugacccug      960

agcugcaacu acaacuccag caaccccucc gucacgcgcu acgaguggaa gccgcacggc     1020

gccugggagg agcccagccu gggcgugcuc aagauccaga agguggggug ggacaacacc     1080

accaucgcgu gcgcccggug caacuccugg ugcagcuggg ccucccccgu cgcccugaac     1140

gugcaguacg cgccccgcga cgugcggguc cgcaagauca agccgcugag cgagauccac     1200

uccggcaaca gcgugucccu ccagugcgac uucagcucca gccaccccaa ggaggugcag     1260

uucuucuggg agaagaacgg gcggcugcug ggcaaggagu cccagcucaa cuucgacagc     1320

aucagccccg aggacgccgg guccuacagc ugcuggguca acaacuccau cggccagacc     1380

gccagcaagg ccuggacgcu ggaggugcug uacgccccgc gccggcuccg cguguccaug     1440

agccccggcg accaggucau ggaggggaag uccgccaccc ugcggugcga gagcgacgcg     1500

aacccgcccg ugucccacua caccugguuc gacuggaaca accagagccu gcccuaccac     1560

ucccagaagc uccgccugga gcccgugaag guccagcaca gcggcgccua cuggugccag     1620

gggaccaacu ccgugggcaa ggggcggagc ccccugucca cgcucaccgu guacuacagc     1680

cccgagacca ucggccgccg cgucgccgug ggccuggggu ccugccuggc cauccucauc     1740

cuggccaucu gcggccugaa gcuccagcgg cgcgacgcgg agagcagcga gaugcagcgg     1800

ccgccccgga ccugcgacga caccgugacg uacuccgccc ugcacaagcg ccaggucggg     1860

gacuacgaga acgugauccc cgacuucccc gaggacgagg gcauccacua cagcgagcug     1920

auccaguucg gggugggcga gcgcccgcag gcccaggaga acgucgacua cgugauccug     1980

aagcacuga                                                             1989


<210>  807
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD22__Homo_sapiens__AAC18956

<400>  807
auggagucca agaccgagaa guggauggag cgcauccacc ucaacgucuc cgagcgcccc       60

uucccccccc acauccagcu cccccccgag auccaggagu cccaggaggu cacccucacc      120

ugccuccuca acuucuccug cuacggcuac cccauccagc uccaguggcu ccucgagggc      180

guccccaugc gccaggccgc cgucaccucc accucccuca ccaucaaguc cgucuucacc      240

cgcuccgagc ucaaguucuc cccccagugg ucccaccacg gcaagaucgu caccugccag      300

cuccaggacg ccgacggcaa guuccucucc aacgacaccg uccagcucaa cgucaagcac      360

acccccaagc ucgagaucaa ggucaccccc uccgacgcca ucguccgcga gggcgacucc      420

gucaccauga ccugcgaggu cuccuccacc aaccccgagu acaccaccgu cuccuggcuc      480

aaggacggca ccucccucaa gaagcagaac accuucaccc ucaaccuccg cgaggucacc      540

aaggaccagu ccggcaagua cugcugccag gucuccaacg acgucggccc cggccgcucc      600

gaggaggucu uccuccaggu ccaguacgcc cccgagcccu ccaccgucca gauccuccac      660

ucccccgccg ucgagggcuc ccaggucgag uuccucugca ugucccucgc caacccccuc      720

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggccgcac cgaggagaag      780

guccacaucc ccaagauccu ccccuggcac gccggcaccu acuccugcgu cgccgagaac      840

auccucggca ccggccagcg cggccccggc gccgagcucg acguccagua cccccccaag      900

aaggucacca ccgucaucca gaaccccaug cccauccgcg agggcgacac cgucacccuc      960

uccugcaacu acaacuccuc caaccccucc gucacccgcu acgaguggaa gccccacggc     1020

gccugggagg agcccucccu cggcguccuc aagauccaga aggucggcug ggacaacacc     1080

accaucgccu gcgcccgcug caacuccugg ugcuccuggg ccucccccgu cgcccucaac     1140

guccaguacg ccccccgcga cguccgcguc cgcaagauca agccccucuc cgagauccac     1200

uccggcaacu ccgucucccu ccagugcgac uucuccuccu cccaccccaa ggagguccag     1260

uucuucuggg agaagaacgg ccgccuccuc ggcaaggagu cccagcucaa cuucgacucc     1320

aucucccccg aggacgccgg cuccuacucc ugcuggguca acaacuccau cggccagacc     1380

gccuccaagg ccuggacccu cgagguccuc uacgcccccc gccgccuccg cgucuccaug     1440

ucccccggcg accaggucau ggagggcaag uccgccaccc uccgcugcga guccgacgcc     1500

aacccccccg ucucccacua caccugguuc gacuggaaca accagucccu ccccuaccac     1560

ucccagaagc uccgccucga gcccgucaag guccagcacu ccggcgccua cuggugccag     1620

ggcaccaacu ccgucggcaa gggccgcucc ccccucucca cccucaccgu cuacuacucc     1680

cccgagacca ucggccgccg cgucgccguc ggccucggcu ccugccucgc cauccucauc     1740

cucgccaucu gcggccucaa gcuccagcgc cgcgacgccg aguccuccga gaugcagcgc     1800

cccccccgca ccugcgacga caccgucacc uacuccgccc uccacaagcg ccaggucggc     1860

gacuacgaga acgucauccc cgacuucccc gaggacgagg gcauccacua cuccgagcuc     1920

auccaguucg gcgucggcga gcgcccccag gcccaggaga acgucgacua cgucauccuc     1980

aagcacuga                                                             1989


<210>  808
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD22__Homo_sapiens__AAC18956

<400>  808
auggagagca agaccgaaaa auggauggag agaauccacc ugaacguguc cgaaaggccc       60

uucccuccac auauucagcu cccgcccgag auacaagaau cucaggaggu cacacuuacu      120

ugccuguuga auuuuucaug uuacggcuau ccuauccagu uacaguggcu gcuagagggg      180

guuccaaugc ggcaagccgc ugugacgagu accagccuca caauuaaguc cguauucacu      240

cgcucugaac ugaaauuuuc gccccagugg ucacaccaug gaaagaucgu gaccugccag      300

cuucaggacg cagaugguaa auuccugagc aacgacacag uccaauugaa ugugaagcac      360

accccuaagc ucgagauuaa aguuacucca agugaugcca ucgugcgaga aggcgacucc      420

gucacaauga ccugugaggu gucuagcacg aaccccgagu acacuaccgu auccuggcug      480

aaggauggga caucacugaa aaagcagaau acuuuuaccc ucaacuuacg ugaaguuaca      540

aaagaccaga guggaaagua uugcugucag gugagcaaug augucggccc ugguagaucu      600

gaggaagugu uccugcaagu gcaguacgcg ccagagccgu ccaccgucca gauacuucau      660

ucacccgcug uugaagggag ccaaguggag uuuuugugca ugagucuggc caacccucua      720

ccaacgaauu auacuuggua ccacaacgga aaggagaugc agggcaggac agaagagaaa      780

guacacaucc ccaagauucu cccuuggcau gcaggcaccu auucuugugu ggccgaaaau      840

auccugggga cuggacagcg ggguccaggc gcugagcuug acguccagua ucccccgaaa      900

aaggugacaa ccguuauuca aaacccuaug cccauccgcg aaggggauac ggugacccug      960

uccugcaauu acaacagcuc gaauccaucu gucacaagau acgaguggaa accucacgga     1020

gcaugggagg aacccuccuu gggcgugcuc aagauacaga aaguagguug ggacaacacu     1080

accauugccu gugcuaggug caacucaugg uguaguuggg ccagcccagu ugcgcugaau     1140

gugcaguacg caccccggga uguccgcgug cgaaagauca agccuuuauc cgagauucau     1200

ucugggaaca gcgucucacu gcagugcgac uucaguucca gccacccaaa agaagugcaa     1260

uuuuucuggg agaagaaugg aagacuccuu ggcaaagaau cucagcugaa cuuugauuca     1320

aucaguccgg aggacgccgg cagcuauucc ugcuggguua auaacucuau cgggcagaca     1380

gcuucgaagg ccuggacuuu ggaggugcua uacgcaccca ggcggcugcg uguaagcaug     1440

uccccuggag accaggucau ggaagguaaa ucagcuaccc uccgcuguga gagugaugcc     1500

aauccacccg ugucucacua uacaugguuc gacuggaaca aucaaagccu gccuuaccau     1560

ucccagaaac uuagacugga accaguuaag gugcagcacu caggcgcgua uuggugccag     1620

gggaccaaca gcgucggaaa gggcaggucu cccuugucca cucucacggu guacuacagu     1680

ccggagacaa uuggucggcg aguagccgug gggcugggca gcuguuuagc aauacugauc     1740

cuagcuauuu gcggacucaa gcugcaacgc agagaugccg agucuuccga aaugcagagg     1800

ccuccacgga ccugugacga uacuguuacc uauucagccc uucauaaacg ccaggucggc     1860

gacuacgaga augugauccc cgauuuuccu gaagacgagg ggauacacua uagugaauug     1920

auucaauucg gaguggguga gagaccccag gcucaggaga acgucgauua cguuauccug     1980

aagcauuga                                                             1989


<210>  809
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD22__Homo_sapiens__AAC18956

<400>  809
auggagagca agaccgagaa guggauggag agaauccacc ugaacgugag cgagagaccc       60

uucccccccc acauccagcu gccccccgag auccaggaga gccaggaggu gacccugacc      120

ugccugcuga acuucagcug cuacggcuac cccauccagc ugcaguggcu gcuggagggc      180

gugcccauga gacaggccgc cgugaccagc accagccuga ccaucaagag cguguucacc      240

agaagcgagc ugaaguucag cccccagugg agccaccacg gcaagaucgu gaccugccag      300

cugcaggacg ccgacggcaa guuccugagc aacgacaccg ugcagcugaa cgugaagcac      360

acccccaagc uggagaucaa ggugaccccc agcgacgcca ucgugagaga gggcgacagc      420

gugaccauga ccugcgaggu gagcagcacc aaccccgagu acaccaccgu gagcuggcug      480

aaggacggca ccagccugaa gaagcagaac accuucaccc ugaaccugag agaggugacc      540

aaggaccaga gcggcaagua cugcugccag gugagcaacg acgugggccc cggcagaagc      600

gaggaggugu uccugcaggu gcaguacgcc cccgagccca gcaccgugca gauccugcac      660

agccccgccg uggagggcag ccagguggag uuccugugca ugagccuggc caacccccug      720

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggcagaac cgaggagaag      780

gugcacaucc ccaagauccu gcccuggcac gccggcaccu acagcugcgu ggccgagaac      840

auccugggca ccggccagag aggccccggc gccgagcugg acgugcagua cccccccaag      900

aaggugacca ccgugaucca gaaccccaug cccaucagag agggcgacac cgugacccug      960

agcugcaacu acaacagcag caaccccagc gugaccagau acgaguggaa gccccacggc     1020

gccugggagg agcccagccu gggcgugcug aagauccaga aggugggcug ggacaacacc     1080

accaucgccu gcgccagaug caacagcugg ugcagcuggg ccagccccgu ggcccugaac     1140

gugcaguacg cccccagaga cgugagagug agaaagauca agccccugag cgagauccac     1200

agcggcaaca gcgugagccu gcagugcgac uucagcagca gccaccccaa ggaggugcag     1260

uucuucuggg agaagaacgg cagacugcug ggcaaggaga gccagcugaa cuucgacagc     1320

aucagccccg aggacgccgg cagcuacagc ugcuggguga acaacagcau cggccagacc     1380

gccagcaagg ccuggacccu ggaggugcug uacgccccca gaagacugag agugagcaug     1440

agccccggcg accaggugau ggagggcaag agcgccaccc ugagaugcga gagcgacgcc     1500

aacccccccg ugagccacua caccugguuc gacuggaaca accagagccu gcccuaccac     1560

agccagaagc ugagacugga gcccgugaag gugcagcaca gcggcgccua cuggugccag     1620

ggcaccaaca gcgugggcaa gggcagaagc ccccugagca cccugaccgu guacuacagc     1680

cccgagacca ucggcagaag aguggccgug ggccugggca gcugccuggc cauccugauc     1740

cuggccaucu gcggccugaa gcugcagaga agagacgccg agagcagcga gaugcagaga     1800

ccccccagaa ccugcgacga caccgugacc uacagcgccc ugcacaagag acaggugggc     1860

gacuacgaga acgugauccc cgacuucccc gaggacgagg gcauccacua cagcgagcug     1920

auccaguucg gcgugggcga gagaccccag gcccaggaga acguggacua cgugauccug     1980

aagcacuga                                                             1989


<210>  810
<211>  1989
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD22__Homo_sapiens__AAC18956

<400>  810
auggagagca agaccgaaaa auggauggag agaauccacc ugaacguguc cgaacggccc       60

uucccuccgc auauucagcu ucccccugag auccaagaau cucaggaggu cacacugacg      120

ugccuucuga auuuuagcug uuacggcuau cccauucagc uccaguggcu gcuugagggg      180

guuccuaugc gccaagccgc ugugaccucc acaucucuga ccaucaagag cguguucaca      240

agauccgaac ucaaauuuuc uccccagugg agccaccaug gaaagauugu gaccugccag      300

cugcaggacg ccgauggcaa auuccugucc aacgacacag ugcaacucaa uguuaagcac      360

accccuaagc uggagaucaa agugacgccg agcgaugcga ucguccggga aggggacucu      420

gugaccauga caugugaggu uuccagcacc aaccccgagu acacaaccgu gucuuggcuu      480

aaggauggaa cgucccugaa aaagcagaau acauuuaccc ucaaccugcg cgaagucaca      540

aaagaccaga gcggcaagua uugcugucag gugucuaaug auguggggcc uggaagaucc      600

gaggaagucu uccuucaagu ucaguacgcu cccgagccua gcaccgugca gauucugcau      660

ucccccgccg uggaaggcuc ucaagucgag uuucucugca ugagccuggc caacccgcug      720

ccuaccaauu auacauggua ccacaacggc aaggagaugc aggggcggac ggaagagaaa      780

gugcacaucc ccaagauucu cccuuggcau gcuggaaccu auuccugugu ugccgaaaau      840

auccugggca cagggcagcg cggacccggc gcugagcuug acgugcagua ucccccuaaa      900

aaggucacca cagugauuca aaacccgaug cccaucagag aaggggauac cguuacgcug      960

agcugcaauu acaacucuuc caauccuagc gugacacggu acgaguggaa accccacgga     1020

gccugggagg aaccuucucu cggcguccug aagauucaga aagugggcug ggacaacacc     1080

accaucgcgu gugcccgcug caacagcugg uguuccuggg cuucucccgu cgcccuuaau     1140

gugcaguacg cuccgagaga uguucgggug cgcaagauca agccucugag cgagauucau     1200

uccgggaaca gcgucucucu ccagugcgac uucuccagcu cucaccccaa agaagugcaa     1260

uuuuucuggg agaagaaugg aagacugcug ggcaaagaau cccagcucaa cuuugauagc     1320

aucuccccug aggacgccgg gucuuauagc ugcuggguua auaacuccau uggacagaca     1380

gcgucuaagg ccuggacccu ggaggugcuu uacgcucccc ggcgccugag agucagcaug     1440

uccccuggcg accaggugau ggaagggaaa agcgccacac uccgguguga gucugaugcu     1500

aaucccccgg ugucccacua uacgugguuc gacuggaaca aucaaagccu gccuuaccau     1560

ucucagaagc ucagacugga acccguuaag guccagcacu ccggagccua uuggugccag     1620

ggcaccaaca gcgugggcaa agggcgcucu ccccucagca cacugaccgu guacuacucc     1680

ccugagacaa ucggacggag agucgccgug ggccugggga gcugucucgc uauucugauc     1740

cuugcgaucu gcggacugaa gcuccaacgc cgggaugccg agucuuccga aaugcagaga     1800

ccgccccgca ccugugacga uacgguuacc uauagcgcuc ugcauaaacg gcaggucggc     1860

gacuacgaga augucauucc ugauuuuccc gaagacgagg ggauccacua uuccgaacug     1920

auucaauucg gcgugggaga gagaccucag gcccaggaga acguugauua cgugauccuu     1980

aagcauuga                                                             1989


<210>  811
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__P20273

<400>  811

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  812
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__AAB06448

<400>  812
augcaucucc ucggccccug gcuccugcuc cugguucuag aauacuuggc uuucucugac       60

ucaaguaaau ggguuuuuga gcacccugaa acccucuacg ccugggaggg ggccugcguc      120

uggauccccu gcaccuacag agcccuagau ggugaccugg aaagcuucau ccuguuccac      180

aauccugagu auaacaagaa caccucgaag uuugauggga caagacucua ugaaagcaca      240

aaggauggga agguuccuuc ugagcagaaa agggugcaau uccugggaga caagaauaag      300

aacugcacac ugaguaucca cccggugcac cucaaugaca guggucagcu ggggcugagg      360

auggagucca agacugagaa auggauggaa cgaauacacc ucaaugucuc ugaaaggccu      420

uuuccaccuc auauccagcu cccuccagaa auucaagagu cccaggaagu cacucugacc      480

ugcuugcuga auuucuccug cuauggguau ccgauccaau ugcaguggcu ccuagagggg      540

guuccaauga ggcaggcugc ugucaccucg accuccuuga ccaucaaguc ugucuucacc      600

cggagcgagc ucaaguucuc cccacagugg agucaccaug ggaagauugu gaccugccag      660

cuucaggaug cagaugggaa guuccucucc aaugacacgg ugcagcugaa cgugaagcac      720

accccgaagu uggagaucaa ggucacuccc agugaugcca uagugaggga gggggacucu      780

gugaccauga ccugcgaggu cagcagcagc aacccggagu acacgacggu auccuggcuc      840

aaggauggga ccucgcugaa gaagcagaau acauucacgc uaaaccugcg cgaagugacc      900

aaggaccaga gugggaagua cugcugucag gucuccaaug acgugggccc gggaaggucg      960

gaagaagugu uccugcaagu gcaguaugcc ccggaaccuu ccacgguuca gauccuccac     1020

ucaccggcug uggagggaag ucaagucgag uuucuuugca ugucacuggc caauccucuu     1080

ccaacaaauu acacguggua ccacaauggg aaagaaaugc agggaaggac agaggagaaa     1140

guccacaucc caaagauccu ccccuggcac gcugggacuu auuccugugu ggcagaaaac     1200

auucuuggua cuggacagag gggcccggga gcugagcugg auguccagua uccucccaag     1260

aaggugacca cagugauuca aaaccccaug ccgauucgag aaggagacac agugacccuu     1320

uccuguaacu acaauuccag uaaccccagu guuacccggu augaauggaa accccauggc     1380

gccugggagg agccaucgcu uggggugcug aagauccaaa acguuggcug ggacaacaca     1440

accaucgccu gcgcagcuug uaauaguugg ugcucguggg ccuccccugu cgcccugaau     1500

guccaguaug ccccccgaga cgugaggguc cggaaaauca agccccuuuc cgagauucac     1560

ucuggaaacu cggucagccu ccaaugugac uucucaagca gccaccccaa agaaguccag     1620

uucuucuggg agaaaaaugg caggcuucug gggaaagaaa gccagcugaa uuuugacucc     1680

aucuccccag aagaugcugg gaguuacagc ugcuggguga acaacuccau aggacagaca     1740

gcguccaagg ccuggacacu ugaagugcug uaugcaccca ggaggcugcg uguguccaug     1800

agcccggggg accaagugau ggaggggaag agugcaaccc ugaccuguga gagcgacgcc     1860

aacccucccg ucucccacua caccugguuu gacuggaaua accaaagccu ccccuaccac     1920

agccagaagc ugagauugga gccggugaag guccagcacu cgggugccua cuggugccag     1980

gggaccaaca gugugggcaa gggccguucg ccucucagca cccucaccgu cuacuauagc     2040

ccggagacca ucggcaggcg aguggcugug ggacucgggu ccugccucgc cauccucauc     2100

cuggcaaucu gugggcucaa gcuccagcga cguuggaaga ggacacagag ccagcagggg     2160

cuucaggaga auuccagcgg ccagagcuuc uuugugagga auaaaaaggu uagaagggcc     2220

ccccucucug aaggccccca cucccuggga ugcuacaauc caaugaugga agauggcauu     2280

agcuacacca cccugcgcuu ucccgagaug aacauaccac gaacuggaga ugcagagucc     2340

ucagagaugc agagaccucc cccggacugc gaugacacgg ucacuuauuc agcauugcac     2400

aagcgccaag ugggcgacua ugagaacguc auuccagauu uuccagaaga ugaggggauu     2460

cauuacucag agcugaucca guuugggguc ggggagcggc cucaggcaca agaaaaugug     2520

gacuauguga uccucaaaca uuga                                            2544


<210>  813
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD22__Homo_sapiens__AAB06448

<400>  813
augcaccucc ucggccccug gcugcugcuc cuggugcugg aguaccucgc cuucagcgac       60

uccagcaagu gggucuucga gcacccggag acccuguacg ccugggaggg ggcgugcgug      120

uggauccccu gcaccuaccg cgcccuggac ggcgaccucg aguccuucau ccuguuccac      180

aaccccgagu acaacaagaa cacgagcaag uucgacggga cccggcugua cgaguccacc      240

aaggacggca aggugcccag cgagcagaag cgcguccagu uccucgggga caagaacaag      300

aacugcaccc uguccaucca cccggugcac cugaacgaca gcggccagcu cggccugcgg      360

auggagucca agacggagaa guggauggag cgcauccacc ugaacgugag cgagcggccc      420

uucccgcccc acauccagcu cccgcccgag auccaggagu cccaggaggu cacccugacc      480

ugccugcuca acuucagcug cuacggguac cccauccagc ugcaguggcu gcucgagggc      540

gugcccaugc gccaggccgc cgugaccucc acgagccuga ccaucaaguc cgucuucacc      600

cggagcgagc ugaaguucuc cccgcagugg agccaccacg ggaagaucgu gaccugccag      660

cuccaggacg ccgacggcaa guuccugucc aacgacacgg ugcagcugaa cgucaagcac      720

acccccaagc ucgagaucaa ggugaccccc agcgacgcga ucgugcgcga gggggacagc      780

gucaccauga cgugcgaggu guccagcucc aaccccgagu acaccaccgu gagcuggcug      840

aaggacggca ccucccugaa gaagcagaac acguucaccc ucaaccugcg ggaggucacc      900

aaggaccaga gcggcaagua cugcugccag guguccaacg acguggggcc cggccgcagc      960

gaggaggucu uccuccaggu gcaguacgcc cccgagcccu ccaccgugca gauccugcac     1020

agccccgccg ucgagggguc ccagguggag uuccugugca ugagccuggc caacccgcuc     1080

cccacgaacu acaccuggua ccacaacggc aaggagaugc agggccggac cgaggagaag     1140

guccacaucc ccaagauccu gcccuggcac gcggggaccu acuccugcgu ggccgagaac     1200

auccugggca cggggcagcg cggcccgggg gccgagcucg acgugcagua cccgcccaag     1260

aaggucacca ccgugaucca gaaccccaug cccauccggg agggcgacac cgugacgcug     1320

agcugcaacu acaacuccag caaccccucc gucacccgcu acgaguggaa gccccacggc     1380

gccugggagg agccgagccu gggggugcuc aagauccaga acgugggcug ggacaacacc     1440

accaucgccu gcgcggccug caacuccugg ugcagcuggg ccagccccgu cgcccugaac     1500

gugcaguacg cgccccggga cgugcgcguc cggaagauca agccccuguc cgagauccac     1560

agcgggaacu ccgugagccu ccagugcgac uucuccagcu cccacccgaa ggaggugcag     1620

uucuucuggg agaagaacgg ccgccugcug gggaaggaga gccagcugaa cuucgacucc     1680

aucagccccg aggacgccgg cuccuacagc ugcuggguca acaacuccau cggccagacg     1740

gccagcaagg ccuggacccu cgaggugcug uacgcgcccc ggcgccugcg gguguccaug     1800

agccccgggg accaggucau ggagggcaag uccgccaccc ugaccugcga gagcgacgcc     1860

aacccgcccg ugagccacua caccugguuc gacuggaaca accagucccu gcccuaccac     1920

agccagaagc ugcgccucga gcccgugaag guccagcacu ccggggccua cuggugccag     1980

ggcacgaaca gcguggggaa gggccgcucc ccgcugagca cccugaccgu guacuacucc     2040

cccgagacca ucggccggcg cgucgccgug gggcucggca gcugccuggc cauccugauc     2100

cucgccaucu gcgggcugaa gcugcagcgg cgcuggaagc ggacgcaguc ccagcagggc     2160

cuccaggaga acagcuccgg ccagagcuuc uucgugcgca acaagaaggu ccggcgcgcg     2220

ccccuguccg aggggcccca cagccugggc ugcuacaacc cgaugaugga ggacgggauc     2280

uccuacacca cccuccgguu ccccgagaug aacauccccc gcaccggcga cgccgagagc     2340

uccgagaugc agcggccccc gcccgacugc gacgacacgg ugaccuacag cgcccugcac     2400

aagcgccagg ugggggacua cgagaacguc auccccgacu uccccgagga cgagggcauc     2460

cacuacuccg agcugaucca guucggcgug ggggagcggc cgcaggccca ggagaacgug     2520

gacuacguca uccucaagca cuga                                            2544


<210>  814
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD22__Homo_sapiens__AAB06448

<400>  814
augcaccucc ucggccccug gcuccuccuc cucguccucg aguaccucgc cuucuccgac       60

uccuccaagu gggucuucga gcaccccgag acccucuacg ccugggaggg cgccugcguc      120

uggauccccu gcaccuaccg cgcccucgac ggcgaccucg aguccuucau ccucuuccac      180

aaccccgagu acaacaagaa caccuccaag uucgacggca cccgccucua cgaguccacc      240

aaggacggca agguccccuc cgagcagaag cgcguccagu uccucggcga caagaacaag      300

aacugcaccc ucuccaucca ccccguccac cucaacgacu ccggccagcu cggccuccgc      360

auggagucca agaccgagaa guggauggag cgcauccacc ucaacgucuc cgagcgcccc      420

uucccccccc acauccagcu cccccccgag auccaggagu cccaggaggu cacccucacc      480

ugccuccuca acuucuccug cuacggcuac cccauccagc uccaguggcu ccucgagggc      540

guccccaugc gccaggccgc cgucaccucc accucccuca ccaucaaguc cgucuucacc      600

cgcuccgagc ucaaguucuc cccccagugg ucccaccacg gcaagaucgu caccugccag      660

cuccaggacg ccgacggcaa guuccucucc aacgacaccg uccagcucaa cgucaagcac      720

acccccaagc ucgagaucaa ggucaccccc uccgacgcca ucguccgcga gggcgacucc      780

gucaccauga ccugcgaggu cuccuccucc aaccccgagu acaccaccgu cuccuggcuc      840

aaggacggca ccucccucaa gaagcagaac accuucaccc ucaaccuccg cgaggucacc      900

aaggaccagu ccggcaagua cugcugccag gucuccaacg acgucggccc cggccgcucc      960

gaggaggucu uccuccaggu ccaguacgcc cccgagcccu ccaccgucca gauccuccac     1020

ucccccgccg ucgagggcuc ccaggucgag uuccucugca ugucccucgc caacccccuc     1080

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggccgcac cgaggagaag     1140

guccacaucc ccaagauccu ccccuggcac gccggcaccu acuccugcgu cgccgagaac     1200

auccucggca ccggccagcg cggccccggc gccgagcucg acguccagua cccccccaag     1260

aaggucacca ccgucaucca gaaccccaug cccauccgcg agggcgacac cgucacccuc     1320

uccugcaacu acaacuccuc caaccccucc gucacccgcu acgaguggaa gccccacggc     1380

gccugggagg agcccucccu cggcguccuc aagauccaga acgucggcug ggacaacacc     1440

accaucgccu gcgccgccug caacuccugg ugcuccuggg ccucccccgu cgcccucaac     1500

guccaguacg ccccccgcga cguccgcguc cgcaagauca agccccucuc cgagauccac     1560

uccggcaacu ccgucucccu ccagugcgac uucuccuccu cccaccccaa ggagguccag     1620

uucuucuggg agaagaacgg ccgccuccuc ggcaaggagu cccagcucaa cuucgacucc     1680

aucucccccg aggacgccgg cuccuacucc ugcuggguca acaacuccau cggccagacc     1740

gccuccaagg ccuggacccu cgagguccuc uacgcccccc gccgccuccg cgucuccaug     1800

ucccccggcg accaggucau ggagggcaag uccgccaccc ucaccugcga guccgacgcc     1860

aacccccccg ucucccacua caccugguuc gacuggaaca accagucccu ccccuaccac     1920

ucccagaagc uccgccucga gcccgucaag guccagcacu ccggcgccua cuggugccag     1980

ggcaccaacu ccgucggcaa gggccgcucc ccccucucca cccucaccgu cuacuacucc     2040

cccgagacca ucggccgccg cgucgccguc ggccucggcu ccugccucgc cauccucauc     2100

cucgccaucu gcggccucaa gcuccagcgc cgcuggaagc gcacccaguc ccagcagggc     2160

cuccaggaga acuccuccgg ccaguccuuc uucguccgca acaagaaggu ccgccgcgcc     2220

ccccucuccg agggccccca cucccucggc ugcuacaacc ccaugaugga ggacggcauc     2280

uccuacacca cccuccgcuu ccccgagaug aacauccccc gcaccggcga cgccgagucc     2340

uccgagaugc agcgcccccc ccccgacugc gacgacaccg ucaccuacuc cgcccuccac     2400

aagcgccagg ucggcgacua cgagaacguc auccccgacu uccccgagga cgagggcauc     2460

cacuacuccg agcucaucca guucggcguc ggcgagcgcc cccaggccca ggagaacguc     2520

gacuacguca uccucaagca cuga                                            2544


<210>  815
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD22__Homo_sapiens__AAB06448

<400>  815
augcaucugc ucggccccug gcuucuguug uuagugcugg aguaccuagc cuucagcgac       60

uccucuaagu gggucuuuga acacccugag acccucuaug cuugggaagg ggcaugcguu      120

uggaucccau guacauacag agcccuggau ggagaccuug agucauucau ucuguuucac      180

aacccggaau auaauaaaaa cacuucuaag uucgauggua cgagguugua cgagagcacc      240

aaagacggca aggugcccuc cgagcagaaa cggguacaau uucucgggga uaagaauaag      300

aacugcacac ugucuauaca uccugugcac cugaaugacu cgggacagcu cggcuuacgc      360

auggaaucaa aaacugagaa guggauggaa cgaauccauc ugaacgucag cgagcgucca      420

uuucccccuc acauucagcu uccacccgag auccaggaaa gucaagaggu gaccuugaca      480

ugucugcuaa auuucuccug cuaugguuac ccuauucagc uccaguggcu gcuugaaggg      540

guuccaauga gacaggcggc ugugaccucu acuagccuga caaucaaauc cgucuucacc      600

aggucagagu ugaaguuuag uccgcaaugg agccaccaug gaaaaauagu gacgugucag      660

cuccaggaug ccgacggcaa guuccugucu aacgauacug uacaguuaaa uguuaagcac      720

acccccaaac uggaaaucaa ggugacaccu uccgacgcaa uuguccggga gggcgauuca      780

gugacuauga ccugcgaggu gagcaguucu aacccagaau auacaaccgu cuccuggcuc      840

aaagacggga cgagccuuaa gaaacaaaau acuuuuacac ugaacuugcg cgagguuacc      900

aaggaucagu cgggaaaaua cuguugccag gugucuaaug acguaggucc cggcagaucc      960

gaagaggugu uccuacaagu ccaguacgcc ccugaaccau caacugugca gauccugcau     1020

agucccgcug uugaggggag ccagguggag uuucucugua ugucccuggc aaacccgcuu     1080

ccuacaaauu auaccuggua ccacaacgga aaggaaaugc aaggcaggac ggaggaaaag     1140

guccacauuc ccaaaauccu gccauggcau gccgguaccu auucuugcgu ggcugagaac     1200

auauugggga caggacagcg gggcccuggc gccgaacucg acguacagua ucccccaaag     1260

aaaguuacua ccgugauuca gaaucccaug ccuauccgcg agggggauac agucacucug     1320

agcuguaacu acaauucaag uaacccaucc gugacccgau acgaguggaa gccgcacgga     1380

gcgugggagg aacccagcuu agguguccug aaaauucaaa augugggcug ggacaacaca     1440

accaucgcau gcgccgcuug caauucuugg uguucauggg ccaguccugu ugcacuaaac     1500

gugcaguaug cuccaagaga uguaaggguc cggaagauca agccccucag cgaaauucau     1560

uccgggaaua gugugucgcu gcagugcgac uucagcuccu cacacccuaa agagguucag     1620

uucuuuuggg agaagaacgg acgucuuuug ggcaaagaaa gucaacugaa uuucgauucu     1680

auaagcccag aggacgccgg uuccuacuca uguuggguga acaauagcau cgggcagacu     1740

gcgucuaagg ccuggacgcu cgaaguccug uacgcacccc gcagacuuag gguguccaug     1800

aguccgggcg aucagguaau ggagggaaaa agcgcuacac ugaccugcga aucugacgcc     1860

aacccuccag ugucccauua uacuugguuu gauuggaaua accagucauu gcccuaccac     1920

agucaaaagc uccggcugga gccuguuaag guccagcaca gcggcgcuua uuggugucag     1980

gggaccaacu cggugggaaa aggucgaucc cccuuaucua cacugaccgu guacuauagc     2040

ccagagacua uuggccgcag agucgccguu gggcuaggau caugccucgc aauccugaua     2100

cuugccauuu guggcuugaa gcugcaaagg cgguggaaac gcacacagag ucagcagggu     2160

cuccaagaaa auuccucugg gcagagcuuc uuugugagaa acaagaaagu gaggcgugcu     2220

ccucuguccg agggccccca uucauuagga ugcuacaauc caaugaugga agacggcauc     2280

agcuauacga cccugcgguu cccggagaug aacaucccuc gaacugggga ugcggaaagu     2340

ucugagaugc agagaccccc acccgacugu gacgauacag uaaccuacuc cgcacuucac     2400

aagaggcagg ucggagacua cgagaaugug auuccugauu uuccagaaga cgaggguauc     2460

cauuauagcg aauugauuca auucggcguu ggggagcgcc cccaggccca ggaaaacgug     2520

gauuacguca uacucaagca cuga                                            2544


<210>  816
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD22__Homo_sapiens__AAB06448

<400>  816
augcaccugc ugggccccug gcugcugcug cuggugcugg aguaccuggc cuucagcgac       60

agcagcaagu ggguguucga gcaccccgag acccuguacg ccugggaggg cgccugcgug      120

uggauccccu gcaccuacag agcccuggac ggcgaccugg agagcuucau ccuguuccac      180

aaccccgagu acaacaagaa caccagcaag uucgacggca ccagacugua cgagagcacc      240

aaggacggca aggugcccag cgagcagaag agagugcagu uccugggcga caagaacaag      300

aacugcaccc ugagcaucca ccccgugcac cugaacgaca gcggccagcu gggccugaga      360

auggagagca agaccgagaa guggauggag agaauccacc ugaacgugag cgagagaccc      420

uucccccccc acauccagcu gccccccgag auccaggaga gccaggaggu gacccugacc      480

ugccugcuga acuucagcug cuacggcuac cccauccagc ugcaguggcu gcuggagggc      540

gugcccauga gacaggccgc cgugaccagc accagccuga ccaucaagag cguguucacc      600

agaagcgagc ugaaguucag cccccagugg agccaccacg gcaagaucgu gaccugccag      660

cugcaggacg ccgacggcaa guuccugagc aacgacaccg ugcagcugaa cgugaagcac      720

acccccaagc uggagaucaa ggugaccccc agcgacgcca ucgugagaga gggcgacagc      780

gugaccauga ccugcgaggu gagcagcagc aaccccgagu acaccaccgu gagcuggcug      840

aaggacggca ccagccugaa gaagcagaac accuucaccc ugaaccugag agaggugacc      900

aaggaccaga gcggcaagua cugcugccag gugagcaacg acgugggccc cggcagaagc      960

gaggaggugu uccugcaggu gcaguacgcc cccgagccca gcaccgugca gauccugcac     1020

agccccgccg uggagggcag ccagguggag uuccugugca ugagccuggc caacccccug     1080

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggcagaac cgaggagaag     1140

gugcacaucc ccaagauccu gcccuggcac gccggcaccu acagcugcgu ggccgagaac     1200

auccugggca ccggccagag aggccccggc gccgagcugg acgugcagua cccccccaag     1260

aaggugacca ccgugaucca gaaccccaug cccaucagag agggcgacac cgugacccug     1320

agcugcaacu acaacagcag caaccccagc gugaccagau acgaguggaa gccccacggc     1380

gccugggagg agcccagccu gggcgugcug aagauccaga acgugggcug ggacaacacc     1440

accaucgccu gcgccgccug caacagcugg ugcagcuggg ccagccccgu ggcccugaac     1500

gugcaguacg cccccagaga cgugagagug agaaagauca agccccugag cgagauccac     1560

agcggcaaca gcgugagccu gcagugcgac uucagcagca gccaccccaa ggaggugcag     1620

uucuucuggg agaagaacgg cagacugcug ggcaaggaga gccagcugaa cuucgacagc     1680

aucagccccg aggacgccgg cagcuacagc ugcuggguga acaacagcau cggccagacc     1740

gccagcaagg ccuggacccu ggaggugcug uacgccccca gaagacugag agugagcaug     1800

agccccggcg accaggugau ggagggcaag agcgccaccc ugaccugcga gagcgacgcc     1860

aacccccccg ugagccacua caccugguuc gacuggaaca accagagccu gcccuaccac     1920

agccagaagc ugagacugga gcccgugaag gugcagcaca gcggcgccua cuggugccag     1980

ggcaccaaca gcgugggcaa gggcagaagc ccccugagca cccugaccgu guacuacagc     2040

cccgagacca ucggcagaag aguggccgug ggccugggca gcugccuggc cauccugauc     2100

cuggccaucu gcggccugaa gcugcagaga agauggaaga gaacccagag ccagcagggc     2160

cugcaggaga acagcagcgg ccagagcuuc uucgugagaa acaagaaggu gagaagagcc     2220

ccccugagcg agggccccca cagccugggc ugcuacaacc ccaugaugga ggacggcauc     2280

agcuacacca cccugagauu ccccgagaug aacaucccca gaaccggcga cgccgagagc     2340

agcgagaugc agagaccccc ccccgacugc gacgacaccg ugaccuacag cgcccugcac     2400

aagagacagg ugggcgacua cgagaacgug auccccgacu uccccgagga cgagggcauc     2460

cacuacagcg agcugaucca guucggcgug ggcgagagac cccaggccca ggagaacgug     2520

gacuacguga uccugaagca cuga                                            2544


<210>  817
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD22__Homo_sapiens__AAB06448

<400>  817
augcaucugc ucggccccug gcugcuucug cucgugcugg aguaccuugc cuucagcgac       60

uccucuaagu gggucuuuga acacccugag acccuguaug cuugggaagg ggccugcguu      120

uggaucccgu guacauacag agcgcucgau ggagaccugg agagcuucau ucuguuucac      180

aaccccgaau auaauaaaaa cacguccaag uucgauggca cccggcucua cgagucuaca      240

aaagacggga aggugccuag cgagcagaaa cgcgugcaau uucugggaga uaagaauaag      300

aacugcaccc uuuccaucca ucccguccac cugaaugacu cuggccagcu cgggcugaga      360

auggaaagca aaacagagaa guggauggaa cggauucauc uuaacguguc cgagcgcccu      420

uuucccccuc acauccagcu gccgcccgag auucaggaaa gccaagaggu uacccucaca      480

ugucugcuga auuucucuug cuauggauac ccuauccagc uccaguggcu gcuugaaggc      540

gugcccauga gacaggcugc cgucaccucc acgagccuga ccaucaaauc uguguucaca      600

cgguccgagc ucaaguuuag cccucaaugg ucucaccaug gcaaaauugu uaccugucag      660

cugcaggaug ccgacgggaa guuccuuucc aacgauacag ugcagcugaa ugucaagcac      720

acccccaaac ucgaaaucaa ggugacgccg agcgacgcua uugugcgcga gggagauucc      780

gucacaauga ccugcgaggu uucuagcucc aacccugaau auacaaccgu gagcuggcug      840

aaagacggca ccucucugaa gaaacaaaau acauuuacgc ucaaccugag agaggugacc      900

aaggaucagu ccgggaaaua cuguugccag gucagcaaug acgugggacc cggccggucu      960

gaagagguuu uccuucaagu gcaguacgcc ccugaaccca gcacagucca gauccugcau     1020

ucccccgcug uggagggguc ucagguugag uuucucugua ugagccuggc caacccucuu     1080

ccgaccaauu auacauggua ccacaacgga aaggaaaugc aaggccgcac cgaggaaaag     1140

gugcacauuc ccaaaauccu gccuuggcau gcgggcacgu auuccugcgu cgccgagaac     1200

auucucggga caggacagag aggccccggg gcugaacugg acgugcagua cccucccaag     1260

aaagucacca ccgugaucca gaauccgaug ccuauccggg agggagauac aguuacccug     1320

agcuguaacu auaauucuuc caaccccagc gugacacgcu acgaguggaa gccucacggc     1380

gccugggagg aacccucucu cgggguccug aaaauucaaa augugggaug ggacaacacg     1440

accaucgcuu gcgccgcgug caauuccugg uguagcuggg ccuccccugu ugcucuuaac     1500

gugcaguaug cccccagaga uguccgggug cgcaagauua agccgcuguc ugaaauccau     1560

agcggcaauu ccgugucucu ccagugcgac uucagcucca gccacccuaa agagguucag     1620

uucuuuuggg agaagaacgg cagacugcug gggaaagaau cucaacuuaa uuucgauucc     1680

auuagccccg aggacgcugg aucuuacucc uguuggguca acaauagcau cggccagaca     1740

gccucuaagg ccuggacccu cgaagugcug uacgcucccc ggagacugcg cgugagcaug     1800

uccccugggg aucaggucau ggagggaaaa agcgcgacac uuaccugcga aucugacgcc     1860

aacccgcccg ugucccauua uacgugguuu gauuggaaua accagagccu gccuuaccac     1920

ucccaaaagc uccggcugga gcccguuaag gugcagcacu cuggcgcuua uuggugucag     1980

gggaccaaca gcgucggcaa aggaagaucc ccucucucua cacugaccgu guacuauagc     2040

cccgagacaa ucggccgccg gguugccgug gggcugggau ccugccuugc cauucucauc     2100

cuggcuauuu guggccugaa gcuccaaaga cgcuggaaac ggacccaguc ucagcagggg     2160

cugcaagaaa auagcuccgg acagagcuuc uuugucagaa acaagaaagu gcgccgggcc     2220

ccucuuucug agggccccca uucccugggg ugcuacaauc cgaugaugga agacggcauc     2280

agcuauacga cacucagauu cccugagaug aacauucccc gcaccggaga ugcggaaucu     2340

uccgagaugc agcggccucc cccggacugu gacgauacag uuaccuacag cgcucugcac     2400

aagagacagg ugggcgacua cgagaauguc aucccugauu uucccgaaga cgaggggauc     2460

cauuauucug aacugauuca auucggagug ggcgagcggc cucaggccca ggaaaacgug     2520

gauuacguca uccuuaagca cuga                                            2544


<210>  818
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__Q0EAF5

<400>  818

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  819
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD22__Homo_sapiens__ABK41939

<400>  819
augcaucucc ucggccccug gcuccugcuc cugguucuag aauacuuggc uuucucugac       60

ucaaguaaau ggguuuuuga gcacccugaa acccucuacg ccugggaggg ggccugcguc      120

uggauccccu gcaccuacag agcccuagau ggugaccugg aaagcuucau ccuguuccac      180

aauccugagu auaacaagaa caccucgaag uuugauggga caagacucua ugaaagcaca      240

aaggauggga agguuccuuc ugagcagaaa agggugcaau uccugggaga caagaauaag      300

aacugcacac ugaguaucca cccggugcac cucaaugaca guggucagcu ggggcugagg      360

auggagucca agacugagaa auggauggaa cgaauacacc ucaaugucuc ugaaaggccu      420

uuuccaccuc auauccagcu cccuccagaa auucaagagu cccaggaagu cacucugacc      480

ugcuugcuga auuucuccug cuauggguau ccgauccaau ugcaguggcu ccuagagggg      540

guuccaauga ggcaggcugc ugucaccucg accuccuuga ccaucaaguc ugucuucacc      600

cggagcgagc ucaaguucuc cccacagugg agucaccaug ggaagauugu gaccugccag      660

cuucaggaug cagaugggaa guuccucucc aaugacacgg ugcagcugaa cgugaagcac      720

accccgaagu uggagaucaa ggucacuccc agugaugcca uagugaggga gggggacucu      780

gugaccauga ccugcgaggu cagcagcagc aacccggagu acacgacggu auccuggcuc      840

aaggauggga ccucgcugaa gaagcagaau acauucacgc uaaaccugcg cgaagugacc      900

aaggaccaga gugggaagua cugcugucag gucuccaaug acgugggccc gggaaggucg      960

gaagaagugu uccugcaagu gcaguaugcc ccggaaccuu ccacgguuca gauccuccac     1020

ucaccggcug uggagggaag ucaagucgag uuucuuugca ugucacuggc caauccucuu     1080

ccaacaaauu acacguggua ccacaauggg aaagaaaugc agggaaggac agaggagaaa     1140

guccacaucc caaagauccu ccccuggcac gcugggacuu auuccugugu ggcagaaaac     1200

auucuuggua cuggacagag gggcccggga gcugagcugg auguccagua uccucccaag     1260

aaggugacca cagugauuca aaaccccaug ccgauucgag aaggagacac agugacccuu     1320

uccuguaacu acaauuccag uaaccccagu guuacccggu augaauggaa accccauggc     1380

gccugggagg agccaucgcu uggggugcug aagauccaaa acguuggcug ggacaacaca     1440

accaucgccu gcgcagcuug uaauaguugg ugcucguggg ccuccccugu cgcccugaau     1500

guccaguaug ccccccgaga cgugaggguc cggaaaauca agccccuuuc cgagauucac     1560

ucuggaaacu cggucagccu ccaaugugac uucucaagca gccaccccaa agaaguccag     1620

uucuucuggg agaaaaaugg caggcuucug gggaaagaaa gccagcugaa uuuugacucc     1680

aucuccccag aagaugcugg gaguuacagc ugcuggguga acaacuccau aggacagaca     1740

gcguccaagg ccuggacacu ugaagugcug uaugcaccca ggaggcugcg uguguccaug     1800

agcccggggg accaagugau ggaggggaag agugcaaccc ugaccuguga gagcgacgcc     1860

aacccucccg ucucccacua caccugguuu gacuggaaua accaaagccu ccccuaccac     1920

agccagaagc ugagauugga gccggugaag guccagcacu cgggugccua cuggugccag     1980

gggaccaaca gugugggcaa gggccguucg ccucucagca cccucaccgu cuacuauagc     2040

ccggagacca ucggcaggcg aguggcugug ggacucgggu ccugccucgc cauccucauc     2100

cuggcaaucu gugggcucaa gcuccagcga cguuggaaga ggacacagag ccagcagggg     2160

cuucaggaga auuccagcgg ccagagcuuc uuugugagga auaaaaaggu uagaagggcc     2220

ccccucucug aaggccccca cucccuggga ugcuacaauc caaugaugga agauggcauu     2280

agcuacacca cccugcgcuu ucccgagaug aacauaccac gaacuggaga ugcagagucc     2340

ucagagaugc agagaccucc cccggacugc gaugacacgg ucacuuauuc agcauugcac     2400

aagcgccaag ugggcgacua ugagaacguc auuccagauu uuccagaaga ugaggggauu     2460

cauuacucag agcugaucca guuugggguc ggggagcggc cucaggcaca agaaaaugug     2520

gacuauguga uccucaaaca uuga                                            2544


<210>  820
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD22__Homo_sapiens__ABK41939

<400>  820
augcaccucc ucggccccug gcugcugcuc cuggugcugg aguaccucgc cuucagcgac       60

uccagcaagu gggucuucga gcacccggag acccuguacg ccugggaggg ggcgugcgug      120

uggauccccu gcaccuaccg cgcccuggac ggcgaccucg aguccuucau ccuguuccac      180

aaccccgagu acaacaagaa cacgagcaag uucgacggga cccggcugua cgaguccacc      240

aaggacggca aggugcccag cgagcagaag cgcguccagu uccucgggga caagaacaag      300

aacugcaccc uguccaucca cccggugcac cugaacgaca gcggccagcu cggccugcgg      360

auggagucca agacggagaa guggauggag cgcauccacc ugaacgugag cgagcggccc      420

uucccgcccc acauccagcu cccgcccgag auccaggagu cccaggaggu cacccugacc      480

ugccugcuca acuucagcug cuacggguac cccauccagc ugcaguggcu gcucgagggc      540

gugcccaugc gccaggccgc cgugaccucc acgagccuga ccaucaaguc cgucuucacc      600

cggagcgagc ugaaguucuc cccgcagugg agccaccacg ggaagaucgu gaccugccag      660

cuccaggacg ccgacggcaa guuccugucc aacgacacgg ugcagcugaa cgucaagcac      720

acccccaagc ucgagaucaa ggugaccccc agcgacgcga ucgugcgcga gggggacagc      780

gucaccauga cgugcgaggu guccagcucc aaccccgagu acaccaccgu gagcuggcug      840

aaggacggca ccucccugaa gaagcagaac acguucaccc ucaaccugcg ggaggucacc      900

aaggaccaga gcggcaagua cugcugccag guguccaacg acguggggcc cggccgcagc      960

gaggaggucu uccuccaggu gcaguacgcc cccgagcccu ccaccgugca gauccugcac     1020

agccccgccg ucgagggguc ccagguggag uuccugugca ugagccuggc caacccgcuc     1080

cccacgaacu acaccuggua ccacaacggc aaggagaugc agggccggac cgaggagaag     1140

guccacaucc ccaagauccu gcccuggcac gcggggaccu acuccugcgu ggccgagaac     1200

auccugggca cggggcagcg cggcccgggg gccgagcucg acgugcagua cccgcccaag     1260

aaggucacca ccgugaucca gaaccccaug cccauccggg agggcgacac cgugacgcug     1320

agcugcaacu acaacuccag caaccccucc gucacccgcu acgaguggaa gccccacggc     1380

gccugggagg agccgagccu gggggugcuc aagauccaga acgugggcug ggacaacacc     1440

accaucgccu gcgcggccug caacuccugg ugcagcuggg ccagccccgu cgcccugaac     1500

gugcaguacg cgccccggga cgugcgcguc cggaagauca agccccuguc cgagauccac     1560

agcgggaacu ccgugagccu ccagugcgac uucuccagcu cccacccgaa ggaggugcag     1620

uucuucuggg agaagaacgg ccgccugcug gggaaggaga gccagcugaa cuucgacucc     1680

aucagccccg aggacgccgg cuccuacagc ugcuggguca acaacuccau cggccagacg     1740

gccagcaagg ccuggacccu cgaggugcug uacgcgcccc ggcgccugcg gguguccaug     1800

agccccgggg accaggucau ggagggcaag uccgccaccc ugaccugcga gagcgacgcc     1860

aacccgcccg ugagccacua caccugguuc gacuggaaca accagucccu gcccuaccac     1920

agccagaagc ugcgccucga gcccgugaag guccagcacu ccggggccua cuggugccag     1980

ggcacgaaca gcguggggaa gggccgcucc ccgcugagca cccugaccgu guacuacucc     2040

cccgagacca ucggccggcg cgucgccgug gggcucggca gcugccuggc cauccugauc     2100

cucgccaucu gcgggcugaa gcugcagcgg cgcuggaagc ggacgcaguc ccagcagggc     2160

cuccaggaga acagcuccgg ccagagcuuc uucgugcgca acaagaaggu ccggcgcgcg     2220

ccccuguccg aggggcccca cagccugggc ugcuacaacc cgaugaugga ggacgggauc     2280

uccuacacca cccuccgguu ccccgagaug aacauccccc gcaccggcga cgccgagagc     2340

uccgagaugc agcggccccc gcccgacugc gacgacacgg ugaccuacag cgcccugcac     2400

aagcgccagg ugggggacua cgagaacguc auccccgacu uccccgagga cgagggcauc     2460

cacuacuccg agcugaucca guucggcgug ggggagcggc cgcaggccca ggagaacgug     2520

gacuacguca uccucaagca cuga                                            2544


<210>  821
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD22__Homo_sapiens__ABK41939

<400>  821
augcaccucc ucggccccug gcuccuccuc cucguccucg aguaccucgc cuucuccgac       60

uccuccaagu gggucuucga gcaccccgag acccucuacg ccugggaggg cgccugcguc      120

uggauccccu gcaccuaccg cgcccucgac ggcgaccucg aguccuucau ccucuuccac      180

aaccccgagu acaacaagaa caccuccaag uucgacggca cccgccucua cgaguccacc      240

aaggacggca agguccccuc cgagcagaag cgcguccagu uccucggcga caagaacaag      300

aacugcaccc ucuccaucca ccccguccac cucaacgacu ccggccagcu cggccuccgc      360

auggagucca agaccgagaa guggauggag cgcauccacc ucaacgucuc cgagcgcccc      420

uucccccccc acauccagcu cccccccgag auccaggagu cccaggaggu cacccucacc      480

ugccuccuca acuucuccug cuacggcuac cccauccagc uccaguggcu ccucgagggc      540

guccccaugc gccaggccgc cgucaccucc accucccuca ccaucaaguc cgucuucacc      600

cgcuccgagc ucaaguucuc cccccagugg ucccaccacg gcaagaucgu caccugccag      660

cuccaggacg ccgacggcaa guuccucucc aacgacaccg uccagcucaa cgucaagcac      720

acccccaagc ucgagaucaa ggucaccccc uccgacgcca ucguccgcga gggcgacucc      780

gucaccauga ccugcgaggu cuccuccucc aaccccgagu acaccaccgu cuccuggcuc      840

aaggacggca ccucccucaa gaagcagaac accuucaccc ucaaccuccg cgaggucacc      900

aaggaccagu ccggcaagua cugcugccag gucuccaacg acgucggccc cggccgcucc      960

gaggaggucu uccuccaggu ccaguacgcc cccgagcccu ccaccgucca gauccuccac     1020

ucccccgccg ucgagggcuc ccaggucgag uuccucugca ugucccucgc caacccccuc     1080

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggccgcac cgaggagaag     1140

guccacaucc ccaagauccu ccccuggcac gccggcaccu acuccugcgu cgccgagaac     1200

auccucggca ccggccagcg cggccccggc gccgagcucg acguccagua cccccccaag     1260

aaggucacca ccgucaucca gaaccccaug cccauccgcg agggcgacac cgucacccuc     1320

uccugcaacu acaacuccuc caaccccucc gucacccgcu acgaguggaa gccccacggc     1380

gccugggagg agcccucccu cggcguccuc aagauccaga acgucggcug ggacaacacc     1440

accaucgccu gcgccgccug caacuccugg ugcuccuggg ccucccccgu cgcccucaac     1500

guccaguacg ccccccgcga cguccgcguc cgcaagauca agccccucuc cgagauccac     1560

uccggcaacu ccgucucccu ccagugcgac uucuccuccu cccaccccaa ggagguccag     1620

uucuucuggg agaagaacgg ccgccuccuc ggcaaggagu cccagcucaa cuucgacucc     1680

aucucccccg aggacgccgg cuccuacucc ugcuggguca acaacuccau cggccagacc     1740

gccuccaagg ccuggacccu cgagguccuc uacgcccccc gccgccuccg cgucuccaug     1800

ucccccggcg accaggucau ggagggcaag uccgccaccc ucaccugcga guccgacgcc     1860

aacccccccg ucucccacua caccugguuc gacuggaaca accagucccu ccccuaccac     1920

ucccagaagc uccgccucga gcccgucaag guccagcacu ccggcgccua cuggugccag     1980

ggcaccaacu ccgucggcaa gggccgcucc ccccucucca cccucaccgu cuacuacucc     2040

cccgagacca ucggccgccg cgucgccguc ggccucggcu ccugccucgc cauccucauc     2100

cucgccaucu gcggccucaa gcuccagcgc cgcuggaagc gcacccaguc ccagcagggc     2160

cuccaggaga acuccuccgg ccaguccuuc uucguccgca acaagaaggu ccgccgcgcc     2220

ccccucuccg agggccccca cucccucggc ugcuacaacc ccaugaugga ggacggcauc     2280

uccuacacca cccuccgcuu ccccgagaug aacauccccc gcaccggcga cgccgagucc     2340

uccgagaugc agcgcccccc ccccgacugc gacgacaccg ucaccuacuc cgcccuccac     2400

aagcgccagg ucggcgacua cgagaacguc auccccgacu uccccgagga cgagggcauc     2460

cacuacuccg agcucaucca guucggcguc ggcgagcgcc cccaggccca ggagaacguc     2520

gacuacguca uccucaagca cuga                                            2544


<210>  822
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD22__Homo_sapiens__ABK41939

<400>  822
augcaucugc ucggccccug gcuucuguug uuagugcugg aguaccuagc cuucagcgac       60

uccucuaagu gggucuuuga acacccugag acccucuaug cuugggaagg ggcaugcguu      120

uggaucccau guacauacag agcccuggau ggagaccuug agucauucau ucuguuucac      180

aacccggaau auaauaaaaa cacuucuaag uucgauggua cgagguugua cgagagcacc      240

aaagacggca aggugcccuc cgagcagaaa cggguacaau uucucgggga uaagaauaag      300

aacugcacac ugucuauaca uccugugcac cugaaugacu cgggacagcu cggcuuacgc      360

auggaaucaa aaacugagaa guggauggaa cgaauccauc ugaacgucag cgagcgucca      420

uuucccccuc acauucagcu uccacccgag auccaggaaa gucaagaggu gaccuugaca      480

ugucugcuaa auuucuccug cuaugguuac ccuauucagc uccaguggcu gcuugaaggg      540

guuccaauga gacaggcggc ugugaccucu acuagccuga caaucaaauc cgucuucacc      600

aggucagagu ugaaguuuag uccgcaaugg agccaccaug gaaaaauagu gacgugucag      660

cuccaggaug ccgacggcaa guuccugucu aacgauacug uacaguuaaa uguuaagcac      720

acccccaaac uggaaaucaa ggugacaccu uccgacgcaa uuguccggga gggcgauuca      780

gugacuauga ccugcgaggu gagcaguucu aacccagaau auacaaccgu cuccuggcuc      840

aaagacggga cgagccuuaa gaaacaaaau acuuuuacac ugaacuugcg cgagguuacc      900

aaggaucagu cgggaaaaua cuguugccag gugucuaaug acguaggucc cggcagaucc      960

gaagaggugu uccuacaagu ccaguacgcc ccugaaccau caacugugca gauccugcau     1020

agucccgcug uugaggggag ccagguggag uuucucugua ugucccuggc aaacccgcuu     1080

ccuacaaauu auaccuggua ccacaacgga aaggaaaugc aaggcaggac ggaggaaaag     1140

guccacauuc ccaaaauccu gccauggcau gccgguaccu auucuugcgu ggcugagaac     1200

auauugggga caggacagcg gggcccuggc gccgaacucg acguacagua ucccccaaag     1260

aaaguuacua ccgugauuca gaaucccaug ccuauccgcg agggggauac agucacucug     1320

agcuguaacu acaauucaag uaacccaucc gugacccgau acgaguggaa gccgcacgga     1380

gcgugggagg aacccagcuu agguguccug aaaauucaaa augugggcug ggacaacaca     1440

accaucgcau gcgccgcuug caauucuugg uguucauggg ccaguccugu ugcacuaaac     1500

gugcaguaug cuccaagaga uguaaggguc cggaagauca agccccucag cgaaauucau     1560

uccgggaaua gugugucgcu gcagugcgac uucagcuccu cacacccuaa agagguucag     1620

uucuuuuggg agaagaacgg acgucuuuug ggcaaagaaa gucaacugaa uuucgauucu     1680

auaagcccag aggacgccgg uuccuacuca uguuggguga acaauagcau cgggcagacu     1740

gcgucuaagg ccuggacgcu cgaaguccug uacgcacccc gcagacuuag gguguccaug     1800

aguccgggcg aucagguaau ggagggaaaa agcgcuacac ugaccugcga aucugacgcc     1860

aacccuccag ugucccauua uacuugguuu gauuggaaua accagucauu gcccuaccac     1920

agucaaaagc uccggcugga gccuguuaag guccagcaca gcggcgcuua uuggugucag     1980

gggaccaacu cggugggaaa aggucgaucc cccuuaucua cacugaccgu guacuauagc     2040

ccagagacua uuggccgcag agucgccguu gggcuaggau caugccucgc aauccugaua     2100

cuugccauuu guggcuugaa gcugcaaagg cgguggaaac gcacacagag ucagcagggu     2160

cuccaagaaa auuccucugg gcagagcuuc uuugugagaa acaagaaagu gaggcgugcu     2220

ccucuguccg agggccccca uucauuagga ugcuacaauc caaugaugga agacggcauc     2280

agcuauacga cccugcgguu cccggagaug aacaucccuc gaacugggga ugcggaaagu     2340

ucugagaugc agagaccccc acccgacugu gacgauacag uaaccuacuc cgcacuucac     2400

aagaggcagg ucggagacua cgagaaugug auuccugauu uuccagaaga cgaggguauc     2460

cauuauagcg aauugauuca auucggcguu ggggagcgcc cccaggccca ggaaaacgug     2520

gauuacguca uacucaagca cuga                                            2544


<210>  823
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD22__Homo_sapiens__ABK41939

<400>  823
augcaccugc ugggccccug gcugcugcug cuggugcugg aguaccuggc cuucagcgac       60

agcagcaagu ggguguucga gcaccccgag acccuguacg ccugggaggg cgccugcgug      120

uggauccccu gcaccuacag agcccuggac ggcgaccugg agagcuucau ccuguuccac      180

aaccccgagu acaacaagaa caccagcaag uucgacggca ccagacugua cgagagcacc      240

aaggacggca aggugcccag cgagcagaag agagugcagu uccugggcga caagaacaag      300

aacugcaccc ugagcaucca ccccgugcac cugaacgaca gcggccagcu gggccugaga      360

auggagagca agaccgagaa guggauggag agaauccacc ugaacgugag cgagagaccc      420

uucccccccc acauccagcu gccccccgag auccaggaga gccaggaggu gacccugacc      480

ugccugcuga acuucagcug cuacggcuac cccauccagc ugcaguggcu gcuggagggc      540

gugcccauga gacaggccgc cgugaccagc accagccuga ccaucaagag cguguucacc      600

agaagcgagc ugaaguucag cccccagugg agccaccacg gcaagaucgu gaccugccag      660

cugcaggacg ccgacggcaa guuccugagc aacgacaccg ugcagcugaa cgugaagcac      720

acccccaagc uggagaucaa ggugaccccc agcgacgcca ucgugagaga gggcgacagc      780

gugaccauga ccugcgaggu gagcagcagc aaccccgagu acaccaccgu gagcuggcug      840

aaggacggca ccagccugaa gaagcagaac accuucaccc ugaaccugag agaggugacc      900

aaggaccaga gcggcaagua cugcugccag gugagcaacg acgugggccc cggcagaagc      960

gaggaggugu uccugcaggu gcaguacgcc cccgagccca gcaccgugca gauccugcac     1020

agccccgccg uggagggcag ccagguggag uuccugugca ugagccuggc caacccccug     1080

cccaccaacu acaccuggua ccacaacggc aaggagaugc agggcagaac cgaggagaag     1140

gugcacaucc ccaagauccu gcccuggcac gccggcaccu acagcugcgu ggccgagaac     1200

auccugggca ccggccagag aggccccggc gccgagcugg acgugcagua cccccccaag     1260

aaggugacca ccgugaucca gaaccccaug cccaucagag agggcgacac cgugacccug     1320

agcugcaacu acaacagcag caaccccagc gugaccagau acgaguggaa gccccacggc     1380

gccugggagg agcccagccu gggcgugcug aagauccaga acgugggcug ggacaacacc     1440

accaucgccu gcgccgccug caacagcugg ugcagcuggg ccagccccgu ggcccugaac     1500

gugcaguacg cccccagaga cgugagagug agaaagauca agccccugag cgagauccac     1560

agcggcaaca gcgugagccu gcagugcgac uucagcagca gccaccccaa ggaggugcag     1620

uucuucuggg agaagaacgg cagacugcug ggcaaggaga gccagcugaa cuucgacagc     1680

aucagccccg aggacgccgg cagcuacagc ugcuggguga acaacagcau cggccagacc     1740

gccagcaagg ccuggacccu ggaggugcug uacgccccca gaagacugag agugagcaug     1800

agccccggcg accaggugau ggagggcaag agcgccaccc ugaccugcga gagcgacgcc     1860

aacccccccg ugagccacua caccugguuc gacuggaaca accagagccu gcccuaccac     1920

agccagaagc ugagacugga gcccgugaag gugcagcaca gcggcgccua cuggugccag     1980

ggcaccaaca gcgugggcaa gggcagaagc ccccugagca cccugaccgu guacuacagc     2040

cccgagacca ucggcagaag aguggccgug ggccugggca gcugccuggc cauccugauc     2100

cuggccaucu gcggccugaa gcugcagaga agauggaaga gaacccagag ccagcagggc     2160

cugcaggaga acagcagcgg ccagagcuuc uucgugagaa acaagaaggu gagaagagcc     2220

ccccugagcg agggccccca cagccugggc ugcuacaacc ccaugaugga ggacggcauc     2280

agcuacacca cccugagauu ccccgagaug aacaucccca gaaccggcga cgccgagagc     2340

agcgagaugc agagaccccc ccccgacugc gacgacaccg ugaccuacag cgcccugcac     2400

aagagacagg ugggcgacua cgagaacgug auccccgacu uccccgagga cgagggcauc     2460

cacuacagcg agcugaucca guucggcgug ggcgagagac cccaggccca ggagaacgug     2520

gacuacguga uccugaagca cuga                                            2544


<210>  824
<211>  2544
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD22__Homo_sapiens__ABK41939

<400>  824
augcaucugc ucggccccug gcugcuucug cucgugcugg aguaccuugc cuucagcgac       60

uccucuaagu gggucuuuga acacccugag acccuguaug cuugggaagg ggccugcguu      120

uggaucccgu guacauacag agcgcucgau ggagaccugg agagcuucau ucuguuucac      180

aaccccgaau auaauaaaaa cacguccaag uucgauggca cccggcucua cgagucuaca      240

aaagacggga aggugccuag cgagcagaaa cgcgugcaau uucugggaga uaagaauaag      300

aacugcaccc uuuccaucca ucccguccac cugaaugacu cuggccagcu cgggcugaga      360

auggaaagca aaacagagaa guggauggaa cggauucauc uuaacguguc cgagcgcccu      420

uuucccccuc acauccagcu gccgcccgag auucaggaaa gccaagaggu uacccucaca      480

ugucugcuga auuucucuug cuauggauac ccuauccagc uccaguggcu gcuugaaggc      540

gugcccauga gacaggcugc cgucaccucc acgagccuga ccaucaaauc uguguucaca      600

cgguccgagc ucaaguuuag cccucaaugg ucucaccaug gcaaaauugu uaccugucag      660

cugcaggaug ccgacgggaa guuccuuucc aacgauacag ugcagcugaa ugucaagcac      720

acccccaaac ucgaaaucaa ggugacgccg agcgacgcua uugugcgcga gggagauucc      780

gucacaauga ccugcgaggu uucuagcucc aacccugaau auacaaccgu gagcuggcug      840

aaagacggca ccucucugaa gaaacaaaau acauuuacgc ucaaccugag agaggugacc      900

aaggaucagu ccgggaaaua cuguugccag gucagcaaug acgugggacc cggccggucu      960

gaagagguuu uccuucaagu gcaguacgcc ccugaaccca gcacagucca gauccugcau     1020

ucccccgcug uggagggguc ucagguugag uuucucugua ugagccuggc caacccucuu     1080

ccgaccaauu auacauggua ccacaacgga aaggaaaugc aaggccgcac cgaggaaaag     1140

gugcacauuc ccaaaauccu gccuuggcau gcgggcacgu auuccugcgu cgccgagaac     1200

auucucggga caggacagag aggccccggg gcugaacugg acgugcagua cccucccaag     1260

aaagucacca ccgugaucca gaauccgaug ccuauccggg agggagauac aguuacccug     1320

agcuguaacu auaauucuuc caaccccagc gugacacgcu acgaguggaa gccucacggc     1380

gccugggagg aacccucucu cgggguccug aaaauucaaa augugggaug ggacaacacg     1440

accaucgcuu gcgccgcgug caauuccugg uguagcuggg ccuccccugu ugcucuuaac     1500

gugcaguaug cccccagaga uguccgggug cgcaagauua agccgcuguc ugaaauccau     1560

agcggcaauu ccgugucucu ccagugcgac uucagcucca gccacccuaa agagguucag     1620

uucuuuuggg agaagaacgg cagacugcug gggaaagaau cucaacuuaa uuucgauucc     1680

auuagccccg aggacgcugg aucuuacucc uguuggguca acaauagcau cggccagaca     1740

gccucuaagg ccuggacccu cgaagugcug uacgcucccc ggagacugcg cgugagcaug     1800

uccccugggg aucaggucau ggagggaaaa agcgcgacac uuaccugcga aucugacgcc     1860

aacccgcccg ugucccauua uacgugguuu gauuggaaua accagagccu gccuuaccac     1920

ucccaaaagc uccggcugga gcccguuaag gugcagcacu cuggcgcuua uuggugucag     1980

gggaccaaca gcgucggcaa aggaagaucc ccucucucua cacugaccgu guacuauagc     2040

cccgagacaa ucggccgccg gguugccgug gggcugggau ccugccuugc cauucucauc     2100

cuggcuauuu guggccugaa gcuccaaaga cgcuggaaac ggacccaguc ucagcagggg     2160

cugcaagaaa auagcuccgg acagagcuuc uuugucagaa acaagaaagu gcgccgggcc     2220

ccucuuucug agggccccca uucccugggg ugcuacaauc cgaugaugga agacggcauc     2280

agcuauacga cacucagauu cccugagaug aacauucccc gcaccggaga ugcggaaucu     2340

uccgagaugc agcggccucc cccggacugu gacgauacag uuaccuacag cgcucugcac     2400

aagagacagg ugggcgacua cgagaauguc aucccugauu uucccgaaga cgaggggauc     2460

cauuauucug aacugauuca auucggagug ggcgagcggc cucaggccca ggaaaacgug     2520

gauuacguca uccuuaagca cuga                                            2544


<210>  825
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD276__Homo_sapiens__Q5ZPR3

<400>  825

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  826
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD276__Homo_sapiens__CAE47548

<400>  826
augcugcguc ggcggggcag cccuggcaug ggugugcaug ugggugcagc ccugggagca       60

cugugguucu gccucacagg agcccuggag guccaggucc cugaagaccc agugguggca      120

cuggugggca ccgaugccac ccugugcugc uccuucuccc ccgagccugg cuucagccug      180

gcacagcuca accucaucug gcagcugaca gauaccaaac agcuggugca cagcuuugcu      240

gagggccagg accagggcag cgccuaugcc aaccgcacgg cccucuuccc ggaccugcug      300

gcacagggca acgcaucccu gaggcugcag cgcgugcgug uggcggacga gggcagcuuc      360

accugcuucg ugagcauccg ggauuucggc agcgcugccg ucagccugca gguggccgcu      420

cccuacucga agcccagcau gacccuggag cccaacaagg accugcggcc aggggacacg      480

gugaccauca cgugcuccag cuaccagggc uacccugagg cugagguguu cuggcaggau      540

gggcagggug ugccccugac uggcaacgug accacgucgc agauggccaa cgagcagggc      600

uuguuugaug ugcacagcau ccugcgggug gugcugggug caaauggcac cuacagcugc      660

cuggugcgca accccgugcu gcagcaggau gcgcacagcu cugucaccau cacaccccag      720

agaagcccca caggagccgu ggagguccag gucccugagg acccgguggu ggcccuagug      780

ggcaccgaug ccacccugcg cugcuccuuc ucccccgagc cuggcuucag ccuggcacag      840

cucaaccuca ucuggcagcu gacagacacc aaacagcugg ugcacaguuu caccgaaggc      900

cgggaccagg gcagcgccua ugccaaccgc acggcccucu ucccggaccu gcuggcacaa      960

ggcaaugcau cccugaggcu gcagcgcgug cguguggcgg acgagggcag cuucaccugc     1020

uucgugagca uccgggauuu cggcagcgcu gccgucagcc ugcagguggc cgcucccuac     1080

ucgaagccca gcaugacccu ggagcccaac aaggaccugc ggccagggga cacggugacc     1140

aucacgugcu ccagcuaccg gggcuacccu gaggcugagg uguucuggca ggaugggcag     1200

ggugugcccc ugacuggcaa cgugaccacg ucgcagaugg ccaacgagca gggcuuguuu     1260

gaugugcaca gcguccugcg gguggugcug ggugcgaaug gcaccuacag cugccuggug     1320

cgcaaccccg ugcugcagca ggaugcgcac ggcucuguca ccaucacagg gcagccuaug     1380

acauuccccc cagaggcccu gugggugacc guggggcugu cugucugucu cauugcacug     1440

cugguggccc uggcuuucgu gugcuggaga aagaucaaac agagcuguga ggaggagaau     1500

gcaggagcug aggaccagga uggggaggga gaaggcucca agacagcccu gcagccucug     1560

aaacacucug acagcaaaga agaugaugga caagaaauag ccuga                     1605


<210>  827
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD276__Homo_sapiens__CAE47548

<400>  827
augcugcgcc ggcgcggcag ccccgggaug ggcgugcacg ucggggccgc ccucggcgcg       60

cugugguucu gccugaccgg ggcccucgag guccaggugc cggaggaccc cgugguggcc      120

cuggugggca ccgacgccac gcugugcugc uccuucagcc ccgagcccgg cuucucccuc      180

gcccagcuga accugaucug gcagcucacc gacaccaagc agcuggucca cagcuucgcg      240

gaggggcagg accagggcuc cgccuacgcc aaccggaccg cccuguuccc ggaccuccug      300

gcgcagggga acgccagccu gcgccuccag cgggugcgcg uggccgacga gggcuccuuc      360

acgugcuucg ucagcauccg ggacuucggg uccgccgccg ugagccucca gguggcggcc      420

cccuacucca agcccagcau gacccuggag cccaacaagg accugcgccc gggcgacacc      480

gucaccauca cgugcuccag cuaccagggc uaccccgagg ccgagguguu cuggcaggac      540

gggcagggcg ugccccugac cgggaacguc accaccuccc agauggccaa cgagcagggc      600

cuguucgacg ugcacagcau ccuccgggug guccugggcg ccaacgggac guacuccugc      660

cuggugcgca accccgugcu ccagcaggac gcgcacagcu ccgucaccau caccccgcag      720

cggagcccca ccggcgccgu ggaggugcag guccccgagg accccguggu cgcccuggug      780

gggacggacg ccacccugcg cugcagcuuc uccccggagc ccggcuucag ccucgcccag      840

cugaaccuga ucuggcagcu caccgacacc aagcagcugg ugcacuccuu cacggagggg      900

cgggaccagg gcagcgcgua cgccaaccgc accgcccugu uccccgaccu ccuggcccag      960

ggcaacgccu cccugcggcu ccagcgcguc cggguggcgg acgaggggag cuucacgugc     1020

uucgugucca uccgcgacuu cggcagcgcc gccgucuccc uccagguggc cgcgcccuac     1080

agcaagccgu ccaugacccu ggagcccaac aaggaccugc ggcccgggga caccgugacc     1140

aucacgugca gcuccuaccg cggcuacccc gaggccgagg ucuucuggca ggacgggcag     1200

ggcgugccgc ugaccggcaa cgugaccacc agccagaugg ccaacgagca ggggcuguuc     1260

gacguccacu ccgugcuccg ggugguccug ggcgccaacg ggaccuacag cugccuggug     1320

cgcaaccccg ugcuccagca ggacgcccac ggcuccguca ccaucacggg gcagcccaug     1380

accuucccgc ccgaggcgcu gugggugacc gugggccuga gcgucugccu caucgcccug     1440

cugguggccc uggccuucgu gugcuggcgc aagaucaagc aguccugcga ggaggagaac     1500

gccggcgcgg aggaccagga cggggagggc gaggggagca agaccgcccu ccagccccug     1560

aagcacagcg acuccaagga ggacgacggc caggagaucg ccuga                     1605


<210>  828
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD276__Homo_sapiens__CAE47548

<400>  828
augcuccgcc gccgcggcuc ccccggcaug ggcguccacg ucggcgccgc ccucggcgcc       60

cucugguucu gccucaccgg cgcccucgag guccaggucc ccgaggaccc cgucgucgcc      120

cucgucggca ccgacgccac ccucugcugc uccuucuccc ccgagcccgg cuucucccuc      180

gcccagcuca accucaucug gcagcucacc gacaccaagc agcucgucca cuccuucgcc      240

gagggccagg accagggcuc cgccuacgcc aaccgcaccg cccucuuccc cgaccuccuc      300

gcccagggca acgccucccu ccgccuccag cgcguccgcg ucgccgacga gggcuccuuc      360

accugcuucg ucuccauccg cgacuucggc uccgccgccg ucucccucca ggucgccgcc      420

cccuacucca agcccuccau gacccucgag cccaacaagg accuccgccc cggcgacacc      480

gucaccauca ccugcuccuc cuaccagggc uaccccgagg ccgaggucuu cuggcaggac      540

ggccagggcg ucccccucac cggcaacguc accaccuccc agauggccaa cgagcagggc      600

cucuucgacg uccacuccau ccuccgcguc guccucggcg ccaacggcac cuacuccugc      660

cucguccgca accccguccu ccagcaggac gcccacuccu ccgucaccau caccccccag      720

cgcuccccca ccggcgccgu cgagguccag guccccgagg accccgucgu cgcccucguc      780

ggcaccgacg ccacccuccg cugcuccuuc ucccccgagc ccggcuucuc ccucgcccag      840

cucaaccuca ucuggcagcu caccgacacc aagcagcucg uccacuccuu caccgagggc      900

cgcgaccagg gcuccgccua cgccaaccgc accgcccucu uccccgaccu ccucgcccag      960

ggcaacgccu cccuccgccu ccagcgcguc cgcgucgccg acgagggcuc cuucaccugc     1020

uucgucucca uccgcgacuu cggcuccgcc gccgucuccc uccaggucgc cgcccccuac     1080

uccaagcccu ccaugacccu cgagcccaac aaggaccucc gccccggcga caccgucacc     1140

aucaccugcu ccuccuaccg cggcuacccc gaggccgagg ucuucuggca ggacggccag     1200

ggcguccccc ucaccggcaa cgucaccacc ucccagaugg ccaacgagca gggccucuuc     1260

gacguccacu ccguccuccg cgucguccuc ggcgccaacg gcaccuacuc cugccucguc     1320

cgcaaccccg uccuccagca ggacgcccac ggcuccguca ccaucaccgg ccagcccaug     1380

accuuccccc ccgaggcccu cugggucacc gucggccucu ccgucugccu caucgcccuc     1440

cucgucgccc ucgccuucgu cugcuggcgc aagaucaagc aguccugcga ggaggagaac     1500

gccggcgccg aggaccagga cggcgagggc gagggcucca agaccgcccu ccagccccuc     1560

aagcacuccg acuccaagga ggacgacggc caggagaucg ccuga                     1605


<210>  829
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD276__Homo_sapiens__CAE47548

<400>  829
augcugagaa ggcggggcag ccccgggaug ggagugcacg ucggugccgc ucucggcgca       60

cuuugguucu gccugaccgg ggccuuggag guucaggugc cugaagaccc aguaguggcg      120

uuagucggaa cagaugcuac ucuguguugc uccuuuucuc cggagcccgg cuucucacua      180

gcccaacuca accugaucug gcagcuuacg gacaccaagc agcuggugca uaguuuugca      240

gaaggucagg aucaagggag cgccuacgcu aaucgcacag cauuguuccc ugaccuccug      300

gcccagggaa acgcuucccu gcgacuccag cguguuagag uggccgauga gggcucuuuu      360

acuuguuucg ucucgauuag ggacuuuggc ucagcggcag ugagcuuaca gguagccgcu      420

ccauauagua aacccuccau gacccuggaa ccuaauaagg aucuucggcc aggggacaca      480

guuaccauaa cuugcucuag cuaccaagga uaucccgagg ccgagguguu cuggcaggau      540

ggucagggcg ucccuuugac agggaacgug accacguccc agauggcaaa ugaacaagga      600

cuguuugacg ugcacucaau ccuacgcguc guucucggcg cuaacgguac uuacaguugu      660

cuggugagaa auccaguacu ucagcaggau gcccauagcu cugugaccau uacaccgcaa      720

agguccccca cuggggcggu cgaggugcag guuccugaag acccaguggu cgcccuggug      780

ggaaccgaug caacauugcg gugcucauuc agccccgagc cuggcuuuag ucucgcucag      840

cugaacuuaa ucuggcagcu gaccgacacg aaacaacucg uacacucuuu cacugagggc      900

cgcgaccagg gguccgccua ugcuaaucga acagcccuuu uuccagaucu guuggcacag      960

ggaaacgcca gccuaagacu gcagaggguu cggguggcug acgaagguuc guucaccugu     1020

uucgucucua uucgugauuu uggcuccgcg gcagugucac uccaagucgc cgcucccuac     1080

aguaagccga gcaugacucu ggagccuaau aaagaccuuc gccccgggga uacagugacc     1140

aucacgugcu ccucuuauag aggauaccca gaagccgagg uuuucuggca ggacggccag     1200

ggugugccuc ugaccgggaa cguaacaacu agccagaugg caaaugaaca aggcuuguuu     1260

gauguccauu cagugcucag gguugugcug ggagccaacg gcaccuacag uuguuuaguc     1320

cggaaucccg ugcugcagca ggacgcucac ggguccguaa caauaacugg acagccaaug     1380

accuuucccc cugaggcccu augggugaca guuggucuca gcgucugccu gaucgcacuu     1440

uugguggcgc uggcuuucgu guguuggcga aagauuaagc aaucuugcga ggaagagaac     1500

gccggcgcag aagaucagga cggggaggga gaaggcucaa aaaccgcccu ccagccacug     1560

aagcacagug auagcaaaga ggacgacggu caagagaucg cuuga                     1605


<210>  830
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD276__Homo_sapiens__CAE47548

<400>  830
augcugagaa gaagaggcag ccccggcaug ggcgugcacg ugggcgccgc ccugggcgcc       60

cugugguucu gccugaccgg cgcccuggag gugcaggugc ccgaggaccc cgugguggcc      120

cuggugggca ccgacgccac ccugugcugc agcuucagcc ccgagcccgg cuucagccug      180

gcccagcuga accugaucug gcagcugacc gacaccaagc agcuggugca cagcuucgcc      240

gagggccagg accagggcag cgccuacgcc aacagaaccg cccuguuccc cgaccugcug      300

gcccagggca acgccagccu gagacugcag agagugagag uggccgacga gggcagcuuc      360

accugcuucg ugagcaucag agacuucggc agcgccgccg ugagccugca gguggccgcc      420

cccuacagca agcccagcau gacccuggag cccaacaagg accugagacc cggcgacacc      480

gugaccauca ccugcagcag cuaccagggc uaccccgagg ccgagguguu cuggcaggac      540

ggccagggcg ugccccugac cggcaacgug accaccagcc agauggccaa cgagcagggc      600

cuguucgacg ugcacagcau ccugagagug gugcugggcg ccaacggcac cuacagcugc      660

cuggugagaa accccgugcu gcagcaggac gcccacagca gcgugaccau caccccccag      720

agaagcccca ccggcgccgu ggaggugcag gugcccgagg accccguggu ggcccuggug      780

ggcaccgacg ccacccugag augcagcuuc agccccgagc ccggcuucag ccuggcccag      840

cugaaccuga ucuggcagcu gaccgacacc aagcagcugg ugcacagcuu caccgagggc      900

agagaccagg gcagcgccua cgccaacaga accgcccugu uccccgaccu gcuggcccag      960

ggcaacgcca gccugagacu gcagagagug agaguggccg acgagggcag cuucaccugc     1020

uucgugagca ucagagacuu cggcagcgcc gccgugagcc ugcagguggc cgcccccuac     1080

agcaagccca gcaugacccu ggagcccaac aaggaccuga gacccggcga caccgugacc     1140

aucaccugca gcagcuacag aggcuacccc gaggccgagg uguucuggca ggacggccag     1200

ggcgugcccc ugaccggcaa cgugaccacc agccagaugg ccaacgagca gggccuguuc     1260

gacgugcaca gcgugcugag aguggugcug ggcgccaacg gcaccuacag cugccuggug     1320

agaaaccccg ugcugcagca ggacgcccac ggcagcguga ccaucaccgg ccagcccaug     1380

accuuccccc ccgaggcccu gugggugacc gugggccuga gcgugugccu gaucgcccug     1440

cugguggccc uggccuucgu gugcuggaga aagaucaagc agagcugcga ggaggagaac     1500

gccggcgccg aggaccagga cggcgagggc gagggcagca agaccgcccu gcagccccug     1560

aagcacagcg acagcaagga ggacgacggc caggagaucg ccuga                     1605


<210>  831
<211>  1605
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD276__Homo_sapiens__CAE47548

<400>  831
augcugagac ggcgcggcag ccccgggaug ggagugcacg ucggcgccgc ucucggggcc       60

cugugguucu gccuuaccgg agcgcuggag guucaggugc cugaagaccc gguggucgcu      120

cucgugggca cagaugccac gcuguguugc uccuuuucuc ccgagccugg guucagccuu      180

gcccaacuga accucaucug gcagcugacc gacacaaagc agcugguuca uuccuuugcu      240

gaaggacagg aucaaggcuc ugccuacgcu aauagaaccg cccucuuccc cgaccugcuu      300

gcgcagggca acgccagccu gcggcuccag cgcgugagag ucgcugauga gggguccuuu      360

acauguuucg ugucuauucg ggacuuugga agcgccgcug uuucccuuca gguggccgcg      420

ccuuauagca aacccucuau gacccuggaa ccuaauaagg aucugcgccc gggcgacaca      480

gucaccauca cgugcuccag cuaccaaggg uaucccgagg ccgagguguu cuggcaggau      540

ggacagggcg ugccucucac cgggaacguc acaaccucuc agauggcuaa ugaacaagga      600

cuguuugacg uucacuccau ucugagagug gugcucggcg ccaacggcac auacagcugu      660

cugguccgga aucccgugcu ucagcaggau gcucauucuu ccguuaccau cacgccucaa      720

cgcagcccca caggggccgu ggagguccag gugccggaag acccuguugu ggcccugguc      780

ggaaccgaug cuacacucag augcuccuuc ucucccgagc cuggcuuuag ccuggcgcag      840

cuuaaccuga uuuggcagcu caccgacacc aaacaacugg ugcacuccuu cacagagggg      900

cgggaccagg gaagcgccua ugcuaaucgc acggcccugu uucccgaucu ccuggcccag      960

ggcaacgcuu cucuuagacu gcagcggguc cgcguggccg acgaaggguc cuucaccugu     1020

uucguuagca ucagagauuu uggaucugcg gcugugagcc uccaagucgc cgcccccuac     1080

uccaagccuu cuaugacacu ggagccgaau aaagaccuuc ggcccggcga uaccgugaca     1140

auuaccugca gcuccuauag aggcuacccu gaagcugagg uuuucuggca ggacgggcag     1200

ggagugcccc ugacgggcaa cgucacaacc agccagaugg ccaaugaaca agggcucuuu     1260

gaugugcauu cugugcugcg cguuguccug ggagcuaacg gcaccuacuc cugucucgug     1320

cggaauccug ugcugcagca ggacgcccac gggagcguca caaucaccgg ccagcccaug     1380

acauucccgc cugaggcgcu uugggugacg guuggacugu cugugugccu caucgcccug     1440

cuggucgcuc uugccuuugu guguuggaga aagauuaagc aauccugcga ggaagagaac     1500

gcuggcgccg aagaucagga cggggaggga gaaggcagca aaaccgcgcu ccagccccug     1560

aagcacuccg auucuaaaga ggacgacggg caagagaucg ccuga                     1605


<210>  832
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__B4DF51

<400>  832

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Val Ser Asp Gly Ala Ser Trp His Pro Val Cys 
            180                 185                 190         


Pro Ala Asp Thr Ser Ser Gln Cys Gly Pro Pro Ser Cys Pro Ile Gln 
        195                 200                 205             


His Phe Gln Asn 
    210         


<210>  833
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__BAG57312

<400>  833
augccgcugc ugcuacugcu gccccugcug ugggcagacu ugacccacag gcccaaaauc       60

cucaucccug gcacucuaga acccggccac uccaaaaacc ugaccugcuc uguguccugg      120

gccugugagc agggaacacc cccgaucuuc uccugguugu cagcugcccc caccucccug      180

ggccccagga cuacucacuc cucggugcuc auaaucaccc cacggcccca ggaccacggc      240

accaaccuga ccugucaggu gaaguucgcu ggagcuggug ugacuacgga gagaaccauc      300

cagcucaacg ucaccuaugu uccacagaac ccaacaacug guaucuuucc aggagauggc      360

ucagggaaac aagagaccag agcaggagug guucaugggg ccauuggagg agcugguguu      420

acagcccugc ucgcucuuug ucucugccuc aucuucuuca uagugaagac ccacaggagg      480

aaagcagcca ggacagcagu gggcaggaau gacacccacc cuaccacagg gucagccucc      540

ccggugagug auggggcauc cuggcaucca gucuguccug cagacaccuc cucccaaugu      600

ggcccaccgu caugccccau ucagcauuuc cagaacuga                             639


<210>  834
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD33__Homo_sapiens__BAG57312

<400>  834
augccccugc uccugcugcu cccccugcug ugggccgacc ucacccaccg ccccaagauc       60

cugauccccg gcacccugga gcccgggcac agcaagaacc ucacgugcuc cgugagcugg      120

gccugcgagc agggcacccc gcccaucuuc uccuggcuga gcgcggcccc caccucccug      180

gggccccgga ccacgcacag cuccguccuc aucaucaccc cgcgccccca ggaccacggc      240

accaaccuga ccugccaggu gaaguucgcc ggggccggcg ugacgaccga gcggaccauc      300

cagcugaacg ucaccuacgu gccccagaac cccacgaccg gcaucuuccc gggggacggc      360

agcgggaagc aggagacccg cgccggcgug guccacgggg cgaucggcgg cgccggggug      420

accgcccucc uggcccugug ccucugccug aucuucuuca ucgugaagac gcaccggcgc      480

aaggcggccc ggaccgccgu cggccgcaac gacacccacc ccaccacggg guccgccagc      540

cccguguccg acggcgccag cuggcacccc gugugcccgg cggacaccuc cagccagugc      600

ggcccgcccu ccugccccau ccagcacuuc cagaacuga                             639


<210>  835
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD33__Homo_sapiens__BAG57312

<400>  835
augccccucc uccuccuccu cccccuccuc ugggccgacc ucacccaccg ccccaagauc       60

cucauccccg gcacccucga gcccggccac uccaagaacc ucaccugcuc cgucuccugg      120

gccugcgagc agggcacccc ccccaucuuc uccuggcucu ccgccgcccc caccucccuc      180

ggcccccgca ccacccacuc cuccguccuc aucaucaccc cccgccccca ggaccacggc      240

accaaccuca ccugccaggu caaguucgcc ggcgccggcg ucaccaccga gcgcaccauc      300

cagcucaacg ucaccuacgu cccccagaac cccaccaccg gcaucuuccc cggcgacggc      360

uccggcaagc aggagacccg cgccggcguc guccacggcg ccaucggcgg cgccggcguc      420

accgcccucc ucgcccucug ccucugccuc aucuucuuca ucgucaagac ccaccgccgc      480

aaggccgccc gcaccgccgu cggccgcaac gacacccacc ccaccaccgg cuccgccucc      540

cccgucuccg acggcgccuc cuggcacccc gucugccccg ccgacaccuc cucccagugc      600

ggcccccccu ccugccccau ccagcacuuc cagaacuga                             639


<210>  836
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD33__Homo_sapiens__BAG57312

<400>  836
augccccugc uccuucuguu gccuuuacug ugggccgacc uaacccacag accaaagauc       60

cucauuccgg gcacacugga gcccgggcau agcaaaaacc uuacuugcuc cgugucuugg      120

gcuugugaac agggaacgcc uccaauauuc ucauggcuga gugcagcccc caccagcuug      180

gguccuagga caacucacuc cucuguccuc aucauuaccc cacggcccca agaucauggc      240

acaaaucuga ccugccaggu uaaguuugcg ggggcuggag ugacuacaga gcgcaccauc      300

cagcugaacg uaacguacgu gccucagaau ccaacuaccg gcauuuuccc gggugacggg      360

ucgggaaaac aagaaacacg agccggcguc gugcacggcg caaucggggg agccgguguu      420

acugcucucu uagcacugug ucuuugcuug auauuuuuca ucgugaagac ccaucguaga      480

aaagccgcua ggacagccgu cggccggaac gauacccacc ccacgacugg gucagcgagc      540

ccugugagug acggagcauc cuggcaccca guaugucccg ccgauacauc uagccagugc      600

ggcccuccau ccugucccau ucagcauuuu cagaauuga                             639


<210>  837
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD33__Homo_sapiens__BAG57312

<400>  837
augccccugc ugcugcugcu gccccugcug ugggccgacc ugacccacag acccaagauc       60

cugauccccg gcacccugga gcccggccac agcaagaacc ugaccugcag cgugagcugg      120

gccugcgagc agggcacccc ccccaucuuc agcuggcuga gcgccgcccc caccagccug      180

ggccccagaa ccacccacag cagcgugcug aucaucaccc ccagacccca ggaccacggc      240

accaaccuga ccugccaggu gaaguucgcc ggcgccggcg ugaccaccga gagaaccauc      300

cagcugaacg ugaccuacgu gccccagaac cccaccaccg gcaucuuccc cggcgacggc      360

agcggcaagc aggagaccag agccggcgug gugcacggcg ccaucggcgg cgccggcgug      420

accgcccugc uggcccugug ccugugccug aucuucuuca ucgugaagac ccacagaaga      480

aaggccgcca gaaccgccgu gggcagaaac gacacccacc ccaccaccgg cagcgccagc      540

cccgugagcg acggcgccag cuggcacccc gugugccccg ccgacaccag cagccagugc      600

ggccccccca gcugccccau ccagcacuuc cagaacuga                             639


<210>  838
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD33__Homo_sapiens__BAG57312

<400>  838
augccccugc uccugcuucu gccucuccug ugggccgacc uuacccacag accgaagauc       60

cugauucccg gcacacucga gccugggcau agcaaaaacc ugacgugcuc cgugucuugg      120

gcuugugaac agggaacacc cccuaucuuc agcuggcugu ccgccgcgcc caccucucuc      180

ggcccucgga ccacacacag cuccguccug auuaucaccc cgcgccccca agaucauggg      240

acaaaucuua ccugccaggu uaaguuugcu ggagccggcg ugacgaccga gagaacaauu      300

cagcugaacg ugaccuacgu cccucagaau cccacaaccg ggaucuuccc uggagacggc      360

ucuggcaaac aagaaacgcg ggccggggug guucacggag cuaucggcgg ggccggagug      420

acagcucucc uggcccuuug ucugugccuc aucuuuuuca uugucaagac ccaucgcaga      480

aaagcggccc ggacagcugu gggccgcaac gauacccacc ccaccacagg gagcgccucc      540

ccgguuagcg acggagcuuc uuggcacccu gugugucccg ccgauacguc cagccagugc      600

ggcccucccu cuugucccau ucagcauuuu cagaauuga                             639


<210>  839
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__P20138

<400>  839

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  840
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__AAK83654

<400>  840
augccgcugc ugcuacugcu gccccugcug ugggcagggg cccuggcuau ggauccaaau       60

uucuggcugc aagugcagga gucagugacg guacaggagg guuugugcgu ccucgugccc      120

ugcacuuucu uccaucccau acccuacuac gacaagaacu ccccaguuca ugguuacugg      180

uuccgggaag gagccauuau auccagggac ucuccagugg ccacaaacaa gcuagaucaa      240

gaaguacagg aggagacuca gggcagauuc cgccuccuug gggaucccag uaggaacaac      300

ugcucccuga gcaucguaga cgccaggagg agggauaaug guucauacuu cuuucggaug      360

gagagaggaa guaccaaaua caguuacaaa ucuccccagc ucucugugca ugugacagac      420

uugacccaca ggcccaaaau ccucaucccu ggcacucuag aacccggcca cuccaaaaac      480

cugaccugcu cuguguccug ggccugugag cagggaacac ccccgaucuu cuccugguug      540

ucagcugccc ccaccucccu gggccccagg acuacucacu ccucggugcu cauaaucacc      600

ccacggcccc aggaccacgg caccaaccug accugucagg ugaaguucgc uggagcuggu      660

gugacuacgg agagaaccau ccagcucaac gucaccuaug uuccacagaa cccaacaacu      720

gguaucuuuc caggagaugg cucagggaaa caagagacca gagcaggagu gguucauggg      780

gccauuggag gagcuggugu uacagcccug cucgcucuuu gucucugccu caucuucuuc      840

auagugaaga cccacaggag gaaagcagcc aggacagcag ugggcaggaa ugacacccac      900

ccuaccacag ggucagccuc cccgaaacac cagaagaagu ccaaguuaca uggccccacu      960

gaaaccucaa gcuguucagg ugccgccccu acuguggaga uggaugagga gcugcauuau     1020

gcuucccuca acuuucaugg gaugaauccu uccaaggaca ccuccaccga auacucagag     1080

gucaggaccc aguga                                                      1095


<210>  841
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD33__Homo_sapiens__AAK83654

<400>  841
augccccugc uccugcugcu cccgcugcug ugggccggcg cccucgcgau ggaccccaac       60

uucuggcucc aggugcagga gagcgucacc gugcaggagg ggcugugcgu gcucgucccc      120

ugcaccuucu uccaccccau cccguacuac gacaagaacu cccccgugca cggcuacugg      180

uuccgcgagg gggccaucau cagccgggac ucccccgugg ccacgaacaa gcuggaccag      240

gagguccagg aggagaccca gggccgcuuc cggcugcucg gggaccccag ccgcaacaac      300

ugcucccuga gcaucgugga cgcccggcgc cgggacaacg gcuccuacuu cuuccgcaug      360

gagcggggca gcaccaagua cuccuacaag agcccgcagc uguccgugca cgucaccgac      420

cucacgcacc gccccaagau ccugaucccc gggacccugg agcccggcca cagcaagaac      480

cugaccugcu ccgugagcug ggccugcgag caggggaccc cgcccaucuu cuccuggcug      540

agcgcggccc ccacgucccu gggcccccgg accacccaca gcuccgugcu caucaucacc      600

ccgcgccccc aggaccacgg gacgaaccug accugccagg ucaaguucgc cggcgccggc      660

gugaccaccg agcggacgau ccagcugaac gugaccuacg ucccccagaa ccccaccacc      720

gggaucuucc cgggcgacgg gagcggcaag caggagacgc gcgcgggcgu ggugcacggg      780

gccaucggcg gggccggcgu caccgcccuc cuggcccugu gccucugccu gaucuucuuc      840

aucgugaaga cccaccggcg caaggcggcc cggaccgccg uggggcgcaa cgacacgcac      900

cccaccaccg gcagcgccuc ccccaagcac cagaagaagu ccaagcugca cggccccacc      960

gagacgagca gcugcuccgg ggccgcgccg accgucgaga uggacgagga gcuccacuac     1020

gccagccuga acuuccacgg caugaacccc uccaaggaca ccagcaccga guacuccgag     1080

gugcggacgc aguga                                                      1095


<210>  842
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD33__Homo_sapiens__AAK83654

<400>  842
augccccucc uccuccuccu cccccuccuc ugggccggcg cccucgccau ggaccccaac       60

uucuggcucc agguccagga guccgucacc guccaggagg gccucugcgu ccucgucccc      120

ugcaccuucu uccaccccau ccccuacuac gacaagaacu cccccgucca cggcuacugg      180

uuccgcgagg gcgccaucau cucccgcgac ucccccgucg ccaccaacaa gcucgaccag      240

gagguccagg aggagaccca gggccgcuuc cgccuccucg gcgaccccuc ccgcaacaac      300

ugcucccucu ccaucgucga cgcccgccgc cgcgacaacg gcuccuacuu cuuccgcaug      360

gagcgcggcu ccaccaagua cuccuacaag uccccccagc ucuccgucca cgucaccgac      420

cucacccacc gccccaagau ccucaucccc ggcacccucg agcccggcca cuccaagaac      480

cucaccugcu ccgucuccug ggccugcgag cagggcaccc cccccaucuu cuccuggcuc      540

uccgccgccc ccaccucccu cggcccccgc accacccacu ccuccguccu caucaucacc      600

ccccgccccc aggaccacgg caccaaccuc accugccagg ucaaguucgc cggcgccggc      660

gucaccaccg agcgcaccau ccagcucaac gucaccuacg ucccccagaa ccccaccacc      720

ggcaucuucc ccggcgacgg cuccggcaag caggagaccc gcgccggcgu cguccacggc      780

gccaucggcg gcgccggcgu caccgcccuc cucgcccucu gccucugccu caucuucuuc      840

aucgucaaga cccaccgccg caaggccgcc cgcaccgccg ucggccgcaa cgacacccac      900

cccaccaccg gcuccgccuc ccccaagcac cagaagaagu ccaagcucca cggccccacc      960

gagaccuccu ccugcuccgg cgccgccccc accgucgaga uggacgagga gcuccacuac     1020

gccucccuca acuuccacgg caugaacccc uccaaggaca ccuccaccga guacuccgag     1080

guccgcaccc aguga                                                      1095


<210>  843
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD33__Homo_sapiens__AAK83654

<400>  843
augccccugc uccuucuguu gccuuuacug ugggccggcg cucuagcaau ggacccaaac       60

uucuggcucc aggugcaaga gagcgucacc guucaggaag ggcugugcgu gcuuguaccg      120

uguacauuuu uccaccccau cccuuacuau gauaaaaauu ccccagugca uggauacugg      180

uuuagagagg gugccauuau aucuagggac ucacccgucg cgacuaacaa gcuggaucag      240

gaagugcagg aggaaacgca aggccgguuc cgcuugcucg gggacccuag ucgaaauaac      300

ugcagccugu ccaucguuga ugcucguaga agggacaaug gaucuuacuu uuuccggaug      360

gagcgcggcu cgaccaagua uucauauaaa agcccacagc ugagugugca cgucacagau      420

cucacucaua gacccaagau uuuaaucccu gguacccugg agccagggca cuccaaaaac      480

cuuacauguu cugugagcug ggccugcgaa cagggaaccc cgcccauuuu uaguugguug      540

ucagcagccc cuacuucccu gggcccaagg acaacccaua gcucuguacu aaucauaacg      600

ccccggccuc aggaccacgg cacuaaucuc accugucaag uuaaguucgc uggggcagga      660

gugacaacug agcgcaccau ccagcugaac gucacauacg ugccacagaa ucccaccacg      720

gguauuuuuc cgggcgaugg guccggaaag caggaaacuc gagccggcgu gguccacggu      780

gcuaucgggg gagccggcgu uacagcgcuu cuggcauugu gccucugucu gauuuucuuu      840

aucgugaaaa cccauagaag gaaggccgcu cggacugccg uaggccguaa cgacacacac      900

ccuaccacgg ggucagcaag ccccaaacau caaaagaaaa guaaguuaca cggaccaacc      960

gagacaucuu ccugcagcgg ugcugccccu acuguggaga uggaugagga acugcacuau     1020

gcgucgcuca auuuccaugg caugaacccc ucuaaggaca ccuccacaga auacucagag     1080

guccgcacuc aguga                                                      1095


<210>  844
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD33__Homo_sapiens__AAK83654

<400>  844
augccccugc ugcugcugcu gccccugcug ugggccggcg cccuggccau ggaccccaac       60

uucuggcugc aggugcagga gagcgugacc gugcaggagg gccugugcgu gcuggugccc      120

ugcaccuucu uccaccccau ccccuacuac gacaagaaca gccccgugca cggcuacugg      180

uucagagagg gcgccaucau cagcagagac agccccgugg ccaccaacaa gcuggaccag      240

gaggugcagg aggagaccca gggcagauuc agacugcugg gcgaccccag cagaaacaac      300

ugcagccuga gcaucgugga cgccagaaga agagacaacg gcagcuacuu cuucagaaug      360

gagagaggca gcaccaagua cagcuacaag agcccccagc ugagcgugca cgugaccgac      420

cugacccaca gacccaagau ccugaucccc ggcacccugg agcccggcca cagcaagaac      480

cugaccugca gcgugagcug ggccugcgag cagggcaccc cccccaucuu cagcuggcug      540

agcgccgccc ccaccagccu gggccccaga accacccaca gcagcgugcu gaucaucacc      600

cccagacccc aggaccacgg caccaaccug accugccagg ugaaguucgc cggcgccggc      660

gugaccaccg agagaaccau ccagcugaac gugaccuacg ugccccagaa ccccaccacc      720

ggcaucuucc ccggcgacgg cagcggcaag caggagacca gagccggcgu ggugcacggc      780

gccaucggcg gcgccggcgu gaccgcccug cuggcccugu gccugugccu gaucuucuuc      840

aucgugaaga cccacagaag aaaggccgcc agaaccgccg ugggcagaaa cgacacccac      900

cccaccaccg gcagcgccag ccccaagcac cagaagaaga gcaagcugca cggccccacc      960

gagaccagca gcugcagcgg cgccgccccc accguggaga uggacgagga gcugcacuac     1020

gccagccuga acuuccacgg caugaacccc agcaaggaca ccagcaccga guacagcgag     1080

gugagaaccc aguga                                                      1095


<210>  845
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD33__Homo_sapiens__AAK83654

<400>  845
augccccugc uccugcuucu gccucuccug ugggccggcg cucuugccau ggacccgaac       60

uucuggcucc aggugcaaga gagcgucacc guucaggaag ggcugugcgu gcuggugccc      120

uguacauuuu uccacccuau ccccuacuau gauaaaaauu ccccugucca uggauacugg      180

uuuagagagg gcgcgauuau cucucgggac agccccgugg cuacgaacaa gcuggaucag      240

gaaguucagg aggaaaccca agggcgcuuc agacuccugg gagacccuuc ccggaauaac      300

ugcucucuua gcauugugga ugcccgcaga cgggacaaug gcuccuacuu uuuccgcaug      360

gagagagggu cuacaaagua uagcuauaaa uccccgcagc ugagcgucca cgugaccgau      420

cucacacauc ggcccaagau ccugauuccu ggaacccuug agcccggcca cucuaaaaac      480

cugacauguu ccguuagcug ggccugcgaa cagggcaccc cucccaucuu uucuuggcuc      540

uccgcugccc cgacgagccu ggggccucgc accacacauu cuuccgugcu gaucauuacc      600

cccagaccuc aggaccacgg aacaaaucuc accugucaag ucaaguucgc uggcgccggg      660

gugacgacag agcggaccau ccagcugaac gugacauacg ucccccagaa ucccaccacc      720

ggaauuuuuc cuggcgaugg gagcggaaag caggaaacac gcgcgggcgu ugugcacggc      780

gccaucgggg gagcuggcgu gacggcccuu cuggcucucu gccugugucu uauuuucuuu      840

aucgucaaaa cccauagacg gaaggccgcg cgcacagccg uggggagaaa cgacacccac      900

ccgacaaccg gauccgcuuc ucccaaacau caaaagaaaa gcaagcugca cggcccuacg      960

gagacaucca gcugcucugg ggccgcuccc accguugaga uggaugagga acuccacuau     1020

gccucccuga auuuccaugg aaugaacccu agcaaggaca ccucuacaga auacagcgag     1080

gugcggaccc aguga                                                      1095


<210>  846
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__Q546G0

<400>  846

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  847
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD33__Homo_sapiens__CAD36509

<400>  847
augccgcugc ugcuacugcu gccccugcug ugggcagggg cccuggcuau ggauccaaau       60

uucuggcugc aagugcagga gucagugacg guacaggagg guuugugcgu ccucgugccc      120

ugcacuuucu uccaucccau acccuacuac gacaagaacu ccccaguuca ugguuacugg      180

uuccgggaag gagccauuau auccagggac ucuccagugg ccacaaacaa gcuagaucaa      240

gaaguacagg aggagacuca gggcagauuc cgccuccuug gggaucccag uaggaacaac      300

ugcucccuga gcaucguaga cgccaggagg agggauaaug guucauacuu cuuucggaug      360

gagagaggaa guaccaaaua caguuacaaa ucuccccagc ucucugugca ugugacagac      420

uugacccaca ggcccaaaau ccucaucccu ggcacucuag aacccggcca cuccaaaaac      480

cugaccugcu cuguguccug ggccugugag cagggaacac ccccgaucuu cuccugguug      540

ucagcugccc ccaccucccu gggccccagg acuacucacu ccucggugcu cauaaucacc      600

ccacggcccc aggaccacgg caccaaccug accugucagg ugaaguucgc uggagcuggu      660

gugacuacgg agagaaccau ccagcucaac gucaccuaug uuccacagaa cccaacaacu      720

gguaucuuuc caggagaugg cucagggaaa caagagacca gagcaggagu gguucauggg      780

gccauuggag gagcuggugu uacagcccug cucgcucuuu gucucugccu caucuucuuc      840

auagugaaga cccacaggag gaaagcagcc aggacagcag ugggcaggaa ugacacccac      900

ccuaccacag ggucagccuc cccgaaacac cagaagaagu ccaaguuaca uggccccacu      960

gaaaccucaa gcuguucagg ugccgccccu acuguggaga uggaugagga gcugcauuau     1020

gcuucccuca acuuucaugg gaugaauccu uccaaggaca ccuccaccga auacucagag     1080

gucaggaccc aguga                                                      1095


<210>  848
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD33__Homo_sapiens__CAD36509

<400>  848
augccccugc uccugcugcu cccgcugcug ugggccggcg cccucgcgau ggaccccaac       60

uucuggcucc aggugcagga gagcgucacc gugcaggagg ggcugugcgu gcucgucccc      120

ugcaccuucu uccaccccau cccguacuac gacaagaacu cccccgugca cggcuacugg      180

uuccgcgagg gggccaucau cagccgggac ucccccgugg ccacgaacaa gcuggaccag      240

gagguccagg aggagaccca gggccgcuuc cggcugcucg gggaccccag ccgcaacaac      300

ugcucccuga gcaucgugga cgcccggcgc cgggacaacg gcuccuacuu cuuccgcaug      360

gagcggggca gcaccaagua cuccuacaag agcccgcagc uguccgugca cgucaccgac      420

cucacgcacc gccccaagau ccugaucccc gggacccugg agcccggcca cagcaagaac      480

cugaccugcu ccgugagcug ggccugcgag caggggaccc cgcccaucuu cuccuggcug      540

agcgcggccc ccacgucccu gggcccccgg accacccaca gcuccgugcu caucaucacc      600

ccgcgccccc aggaccacgg gacgaaccug accugccagg ucaaguucgc cggcgccggc      660

gugaccaccg agcggacgau ccagcugaac gugaccuacg ucccccagaa ccccaccacc      720

gggaucuucc cgggcgacgg gagcggcaag caggagacgc gcgcgggcgu ggugcacggg      780

gccaucggcg gggccggcgu caccgcccuc cuggcccugu gccucugccu gaucuucuuc      840

aucgugaaga cccaccggcg caaggcggcc cggaccgccg uggggcgcaa cgacacgcac      900

cccaccaccg gcagcgccuc ccccaagcac cagaagaagu ccaagcugca cggccccacc      960

gagacgagca gcugcuccgg ggccgcgccg accgucgaga uggacgagga gcuccacuac     1020

gccagccuga acuuccacgg caugaacccc uccaaggaca ccagcaccga guacuccgag     1080

gugcggacgc aguga                                                      1095


<210>  849
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD33__Homo_sapiens__CAD36509

<400>  849
augccccucc uccuccuccu cccccuccuc ugggccggcg cccucgccau ggaccccaac       60

uucuggcucc agguccagga guccgucacc guccaggagg gccucugcgu ccucgucccc      120

ugcaccuucu uccaccccau ccccuacuac gacaagaacu cccccgucca cggcuacugg      180

uuccgcgagg gcgccaucau cucccgcgac ucccccgucg ccaccaacaa gcucgaccag      240

gagguccagg aggagaccca gggccgcuuc cgccuccucg gcgaccccuc ccgcaacaac      300

ugcucccucu ccaucgucga cgcccgccgc cgcgacaacg gcuccuacuu cuuccgcaug      360

gagcgcggcu ccaccaagua cuccuacaag uccccccagc ucuccgucca cgucaccgac      420

cucacccacc gccccaagau ccucaucccc ggcacccucg agcccggcca cuccaagaac      480

cucaccugcu ccgucuccug ggccugcgag cagggcaccc cccccaucuu cuccuggcuc      540

uccgccgccc ccaccucccu cggcccccgc accacccacu ccuccguccu caucaucacc      600

ccccgccccc aggaccacgg caccaaccuc accugccagg ucaaguucgc cggcgccggc      660

gucaccaccg agcgcaccau ccagcucaac gucaccuacg ucccccagaa ccccaccacc      720

ggcaucuucc ccggcgacgg cuccggcaag caggagaccc gcgccggcgu cguccacggc      780

gccaucggcg gcgccggcgu caccgcccuc cucgcccucu gccucugccu caucuucuuc      840

aucgucaaga cccaccgccg caaggccgcc cgcaccgccg ucggccgcaa cgacacccac      900

cccaccaccg gcuccgccuc ccccaagcac cagaagaagu ccaagcucca cggccccacc      960

gagaccuccu ccugcuccgg cgccgccccc accgucgaga uggacgagga gcuccacuac     1020

gccucccuca acuuccacgg caugaacccc uccaaggaca ccuccaccga guacuccgag     1080

guccgcaccc aguga                                                      1095


<210>  850
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD33__Homo_sapiens__CAD36509

<400>  850
augccccugc uccuucuguu gccuuuacug ugggccggcg cucuagcaau ggacccaaac       60

uucuggcucc aggugcaaga gagcgucacc guucaggaag ggcugugcgu gcuuguaccg      120

uguacauuuu uccaccccau cccuuacuau gauaaaaauu ccccagugca uggauacugg      180

uuuagagagg gugccauuau aucuagggac ucacccgucg cgacuaacaa gcuggaucag      240

gaagugcagg aggaaacgca aggccgguuc cgcuugcucg gggacccuag ucgaaauaac      300

ugcagccugu ccaucguuga ugcucguaga agggacaaug gaucuuacuu uuuccggaug      360

gagcgcggcu cgaccaagua uucauauaaa agcccacagc ugagugugca cgucacagau      420

cucacucaua gacccaagau uuuaaucccu gguacccugg agccagggca cuccaaaaac      480

cuuacauguu cugugagcug ggccugcgaa cagggaaccc cgcccauuuu uaguugguug      540

ucagcagccc cuacuucccu gggcccaagg acaacccaua gcucuguacu aaucauaacg      600

ccccggccuc aggaccacgg cacuaaucuc accugucaag uuaaguucgc uggggcagga      660

gugacaacug agcgcaccau ccagcugaac gucacauacg ugccacagaa ucccaccacg      720

gguauuuuuc cgggcgaugg guccggaaag caggaaacuc gagccggcgu gguccacggu      780

gcuaucgggg gagccggcgu uacagcgcuu cuggcauugu gccucugucu gauuuucuuu      840

aucgugaaaa cccauagaag gaaggccgcu cggacugccg uaggccguaa cgacacacac      900

ccuaccacgg ggucagcaag ccccaaacau caaaagaaaa guaaguuaca cggaccaacc      960

gagacaucuu ccugcagcgg ugcugccccu acuguggaga uggaugagga acugcacuau     1020

gcgucgcuca auuuccaugg caugaacccc ucuaaggaca ccuccacaga auacucagag     1080

guccgcacuc aguga                                                      1095


<210>  851
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD33__Homo_sapiens__CAD36509

<400>  851
augccccugc ugcugcugcu gccccugcug ugggccggcg cccuggccau ggaccccaac       60

uucuggcugc aggugcagga gagcgugacc gugcaggagg gccugugcgu gcuggugccc      120

ugcaccuucu uccaccccau ccccuacuac gacaagaaca gccccgugca cggcuacugg      180

uucagagagg gcgccaucau cagcagagac agccccgugg ccaccaacaa gcuggaccag      240

gaggugcagg aggagaccca gggcagauuc agacugcugg gcgaccccag cagaaacaac      300

ugcagccuga gcaucgugga cgccagaaga agagacaacg gcagcuacuu cuucagaaug      360

gagagaggca gcaccaagua cagcuacaag agcccccagc ugagcgugca cgugaccgac      420

cugacccaca gacccaagau ccugaucccc ggcacccugg agcccggcca cagcaagaac      480

cugaccugca gcgugagcug ggccugcgag cagggcaccc cccccaucuu cagcuggcug      540

agcgccgccc ccaccagccu gggccccaga accacccaca gcagcgugcu gaucaucacc      600

cccagacccc aggaccacgg caccaaccug accugccagg ugaaguucgc cggcgccggc      660

gugaccaccg agagaaccau ccagcugaac gugaccuacg ugccccagaa ccccaccacc      720

ggcaucuucc ccggcgacgg cagcggcaag caggagacca gagccggcgu ggugcacggc      780

gccaucggcg gcgccggcgu gaccgcccug cuggcccugu gccugugccu gaucuucuuc      840

aucgugaaga cccacagaag aaaggccgcc agaaccgccg ugggcagaaa cgacacccac      900

cccaccaccg gcagcgccag ccccaagcac cagaagaaga gcaagcugca cggccccacc      960

gagaccagca gcugcagcgg cgccgccccc accguggaga uggacgagga gcugcacuac     1020

gccagccuga acuuccacgg caugaacccc agcaaggaca ccagcaccga guacagcgag     1080

gugagaaccc aguga                                                      1095


<210>  852
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD33__Homo_sapiens__CAD36509

<400>  852
augccccugc uccugcuucu gccucuccug ugggccggcg cucuugccau ggacccgaac       60

uucuggcucc aggugcaaga gagcgucacc guucaggaag ggcugugcgu gcuggugccc      120

uguacauuuu uccacccuau ccccuacuau gauaaaaauu ccccugucca uggauacugg      180

uuuagagagg gcgcgauuau cucucgggac agccccgugg cuacgaacaa gcuggaucag      240

gaaguucagg aggaaaccca agggcgcuuc agacuccugg gagacccuuc ccggaauaac      300

ugcucucuua gcauugugga ugcccgcaga cgggacaaug gcuccuacuu uuuccgcaug      360

gagagagggu cuacaaagua uagcuauaaa uccccgcagc ugagcgucca cgugaccgau      420

cucacacauc ggcccaagau ccugauuccu ggaacccuug agcccggcca cucuaaaaac      480

cugacauguu ccguuagcug ggccugcgaa cagggcaccc cucccaucuu uucuuggcuc      540

uccgcugccc cgacgagccu ggggccucgc accacacauu cuuccgugcu gaucauuacc      600

cccagaccuc aggaccacgg aacaaaucuc accugucaag ucaaguucgc uggcgccggg      660

gugacgacag agcggaccau ccagcugaac gugacauacg ucccccagaa ucccaccacc      720

ggaauuuuuc cuggcgaugg gagcggaaag caggaaacac gcgcgggcgu ugugcacggc      780

gccaucgggg gagcuggcgu gacggcccuu cuggcucucu gccugugucu uauuuucuuu      840

aucgucaaaa cccauagacg gaaggccgcg cgcacagccg uggggagaaa cgacacccac      900

ccgacaaccg gauccgcuuc ucccaaacau caaaagaaaa gcaagcugca cggcccuacg      960

gagacaucca gcugcucugg ggccgcuccc accguugaga uggaugagga acuccacuau     1020

gccucccuga auuuccaugg aaugaacccu agcaaggaca ccucuacaga auacagcgag     1080

gugcggaccc aguga                                                      1095


<210>  853
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD3E__Homo_sapiens__P07766

<400>  853

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  854
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD3E__Homo_sapiens__AAA52295

<400>  854
augcagucgg gcacucacug gagaguucug ggccucugcc ucuuaucagu ugguguuugg       60

gggcaagaug guaaugaaga aauggguggu auuacacaga caccauauaa agucuccauc      120

ucuggaacca caguaauauu gacaugcccu caguauccug gaucugaaau acuauggcaa      180

cacaaugaua aaaacauagg cggugaugag gaugauaaaa acauaggcag ugaugaggau      240

caccugucac ugaaggaauu uucagaauug gagcaaagug guuauuaugu cugcuacccc      300

agaggaagca aaccagaaga ugcgaacuuu uaucucuacc ugagggcaag agugugugag      360

aacugcaugg agauggaugu gaugucggug gccacaauug ucauagugga caucugcauc      420

acugggggcu ugcugcugcu gguuuacuac uggagcaaga auagaaaggc caaggccaag      480

ccugugacac gaggagcggg ugcuggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccaccuguuc ccaacccaga cuaugagccc auccggaaag gccagcggga ccuguauucu      600

ggccugaauc agagacgcau cuga                                             624


<210>  855
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD3E__Homo_sapiens__AAA52295

<400>  855
augcagagcg gcacccacug gcgcgugcug gggcucugcc ugcuguccgu cggcgugugg       60

gggcaggacg gcaacgagga gaugggcggg aucacccaga cgcccuacaa ggugagcauc      120

uccggcacca ccgucauccu gaccugcccc caguaccccg ggagcgagau ccucuggcag      180

cacaacgaca agaacaucgg cggggacgag gacgacaaga acaucggcuc cgacgaggac      240

caccugagcc ucaaggaguu cuccgagcug gagcagagcg gguacuacgu gugcuacccc      300

cggggcucca agcccgagga cgccaacuuc uaccuguacc uccgcgcccg ggugugcgag      360

aacugcaugg agauggacgu caugagcgug gcgacgaucg ugaucgucga caucugcauc      420

accggcgggc ugcugcuccu gguguacuac ugguccaaga accgcaaggc caaggccaag      480

ccggugaccc ggggcgccgg ggccggcggc cgccagcggg ggcagaacaa ggagcgcccg      540

ccgcccgucc ccaaccccga cuacgagccc auccggaagg gccagcgcga ccuguacagc      600

gggcucaacc agcggcgcau cuga                                             624


<210>  856
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD3E__Homo_sapiens__AAA52295

<400>  856
augcaguccg gcacccacug gcgcguccuc ggccucugcc uccucuccgu cggcgucugg       60

ggccaggacg gcaacgagga gaugggcggc aucacccaga cccccuacaa ggucuccauc      120

uccggcacca ccgucauccu caccugcccc caguaccccg gcuccgagau ccucuggcag      180

cacaacgaca agaacaucgg cggcgacgag gacgacaaga acaucggcuc cgacgaggac      240

caccucuccc ucaaggaguu cuccgagcuc gagcaguccg gcuacuacgu cugcuacccc      300

cgcggcucca agcccgagga cgccaacuuc uaccucuacc uccgcgcccg cgucugcgag      360

aacugcaugg agauggacgu cauguccguc gccaccaucg ucaucgucga caucugcauc      420

accggcggcc uccuccuccu cgucuacuac ugguccaaga accgcaaggc caaggccaag      480

cccgucaccc gcggcgccgg cgccggcggc cgccagcgcg gccagaacaa ggagcgcccc      540

ccccccgucc ccaaccccga cuacgagccc auccgcaagg gccagcgcga ccucuacucc      600

ggccucaacc agcgccgcau cuga                                             624


<210>  857
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD3E__Homo_sapiens__AAA52295

<400>  857
augcagagcg gcacccacug gagagugcug gggcucugcc uucuguccgu cggaguuugg       60

ggucaagacg gcaacgagga aaugggaggg aucacacaga cucccuacaa ggugucuauu      120

ucaggcacga ccguaauauu gacauguccu caguauccag guagugagau cuuauggcag      180

cauaaugaua aaaacauugg gggagacgaa gaugacaaga auaucggcag cgaugaggac      240

caccuguccc uaaaagaguu cucugaacuc gagcaaucgg gcuacuaugu gugcuacccg      300

agggggucaa agcccgaaga ugccaacuuu uaucuguacc uucgggcucg cgucugugag      360

aauugcaugg aaauggacgu gaugagcguu gcaacuauug ugaucgucga uauauguauc      420

accggagguc uguugcuccu gguguauuac uggaguaaaa accgaaaggc caaggcgaaa      480

ccuguaacac guggcgcugg ggccggaggc agacagaggg gucagaauaa ggagcggcca      540

cccccuguuc caaaccccga cuacgagccu auucgcaaag ggcagagaga ucuguauucc      600

ggacucaauc aaaggcggau cuga                                             624


<210>  858
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD3E__Homo_sapiens__AAA52295

<400>  858
augcagagcg gcacccacug gagagugcug ggccugugcc ugcugagcgu gggcgugugg       60

ggccaggacg gcaacgagga gaugggcggc aucacccaga cccccuacaa ggugagcauc      120

agcggcacca ccgugauccu gaccugcccc caguaccccg gcagcgagau ccuguggcag      180

cacaacgaca agaacaucgg cggcgacgag gacgacaaga acaucggcag cgacgaggac      240

caccugagcc ugaaggaguu cagcgagcug gagcagagcg gcuacuacgu gugcuacccc      300

agaggcagca agcccgagga cgccaacuuc uaccuguacc ugagagccag agugugcgag      360

aacugcaugg agauggacgu gaugagcgug gccaccaucg ugaucgugga caucugcauc      420

accggcggcc ugcugcugcu gguguacuac uggagcaaga acagaaaggc caaggccaag      480

cccgugacca gaggcgccgg cgccggcggc agacagagag gccagaacaa ggagagaccc      540

ccccccgugc ccaaccccga cuacgagccc aucagaaagg gccagagaga ccuguacagc      600

ggccugaacc agagaagaau cuga                                             624


<210>  859
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD3E__Homo_sapiens__AAA52295

<400>  859
augcagagcg gcacccacug gagagugcug gggcucugcc ugcuuuccgu cggaguuugg       60

ggccaagacg ggaacgagga aaugggaggc aucacacaga cgcccuacaa ggugucuauu      120

agcgggacca cagugauccu gaccuguccu caguauccgg gauccgagau ucucuggcag      180

cauaaugaua aaaacaucgg cggcgacgaa gaugacaaga auauuggguc ugaugaggac      240

caccugagcc uuaaagaguu cuccgaacug gagcaaucug gauacuaugu cugcuacccc      300

cggggcagca agccugaaga ugccaacuuu uaucucuacc ugcgcgcuag agugugugag      360

aauugcaugg aaauggacgu uauguccgug gccacaaucg ucaucgugga uauuuguauc      420

accgggggac ugcuccugcu uguuuauuac uggagcaaaa accggaaggc gaaggcuaaa      480

cccgugacac gcggcgccgg ggccggaggc agacagcggg gccagaauaa ggagcgcccu      540

cccccugucc cgaaccccga cuacgagccu auuagaaaag ggcagcggga ucuguauucu      600

ggacucaauc aacgcagaau cuga                                             624


<210>  860
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD3Z__Homo_sapiens__P20963

<400>  860

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  861
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD3Z__Homo_sapiens__AAH25703

<400>  861
augaagugga aggcgcuuuu caccgcggcc auccugcagg cacaguugcc gauuacagag       60

gcacagagcu uuggccugcu ggaucccaaa cucugcuacc ugcuggaugg aauccucuuc      120

aucuauggug ucauucucac ugccuuguuc cugagaguga aguucagcag gagcgcagac      180

gcccccgcgu accagcaggg ccagaaccag cucuauaacg agcucaaucu aggacgaaga      240

gaggaguacg auguuuugga caagagacgu ggccgggacc cugagauggg gggaaagccg      300

cagagaagga agaacccuca ggaaggccug uacaaugaac ugcagaaaga uaagauggcg      360

gaggccuaca gugagauugg gaugaaaggc gagcgccgga ggggcaaggg gcacgauggc      420

cuuuaccagg gucucaguac agccaccaag gacaccuacg acgcccuuca caugcaggcc      480

cugcccccuc gcuaa                                                       495


<210>  862
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD3Z__Homo_sapiens__AAH25703

<400>  862
augaagugga aggcccuguu caccgccgcg auccuccagg cccagcugcc caucaccgag       60

gcccagagcu ucggccugcu cgaccccaag cugugcuacc ugcucgacgg gauccuguuc      120

aucuacggcg ugauccugac ggcccucuuc cugcgcguca aguucucccg gagcgccgac      180

gcgcccgccu accagcaggg gcagaaccag cuguacaacg agcucaaccu gggccgccgg      240

gaggaguacg acgugcugga caagcgccgg gggcgcgacc ccgagauggg cggcaagccc      300

cagcggcgca agaacccgca ggaggggcuc uacaacgagc ugcagaagga caagauggcc      360

gaggccuacu ccgagaucgg caugaagggg gagcggcgcc ggggcaaggg gcacgacggc      420

cuguaccagg gccucagcac cgcgaccaag gacaccuacg acgcccugca caugcaggcc      480

cugccgcccc gcuga                                                       495


<210>  863
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD3Z__Homo_sapiens__AAH25703

<400>  863
augaagugga aggcccucuu caccgccgcc auccuccagg cccagcuccc caucaccgag       60

gcccaguccu ucggccuccu cgaccccaag cucugcuacc uccucgacgg cauccucuuc      120

aucuacggcg ucauccucac cgcccucuuc cuccgcguca aguucucccg cuccgccgac      180

gcccccgccu accagcaggg ccagaaccag cucuacaacg agcucaaccu cggccgccgc      240

gaggaguacg acguccucga caagcgccgc ggccgcgacc ccgagauggg cggcaagccc      300

cagcgccgca agaaccccca ggagggccuc uacaacgagc uccagaagga caagauggcc      360

gaggccuacu ccgagaucgg caugaagggc gagcgccgcc gcggcaaggg ccacgacggc      420

cucuaccagg gccucuccac cgccaccaag gacaccuacg acgcccucca caugcaggcc      480

cucccccccc gcuga                                                       495


<210>  864
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD3Z__Homo_sapiens__AAH25703

<400>  864
augaagugga aagcccuguu caccgcugca auccuccagg cccaacuucc cauuacagag       60

gcgcagagcu uuggccuguu ggacccuaag uuaugcuacc ugcuagaugg gauacucuuc      120

aucuauggag ugauucugac ugcucuuuuu cugagaguca aauucuccag gucugccgac      180

gcaccagccu accagcaggg ucaaaaccag uuguauaaug aacucaaccu gggccggcgc      240

gaggaauacg auguucugga caagcgacgu gggagagauc cggagauggg aggcaaaccc      300

cagaggcgga agaauccuca ggaaggucuc uauaacgagu uacaaaagga caaaauggcu      360

gaggcauacu cagaaaucgg gaugaaggga gagcgcagaa ggggcaaagg ccacgauggg      420

cuguaucagg gacuuaguac ggccaccaag gacacauacg augcuuugca uaugcaggcc      480

cugccacccc gguga                                                       495


<210>  865
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD3Z__Homo_sapiens__AAH25703

<400>  865
augaagugga aggcccuguu caccgccgcc auccugcagg cccagcugcc caucaccgag       60

gcccagagcu ucggccugcu ggaccccaag cugugcuacc ugcuggacgg cauccuguuc      120

aucuacggcg ugauccugac cgcccuguuc cugagaguga aguucagcag aagcgccgac      180

gcccccgccu accagcaggg ccagaaccag cuguacaacg agcugaaccu gggcagaaga      240

gaggaguacg acgugcugga caagagaaga ggcagagacc ccgagauggg cggcaagccc      300

cagagaagaa agaaccccca ggagggccug uacaacgagc ugcagaagga caagauggcc      360

gaggccuaca gcgagaucgg caugaagggc gagagaagaa gaggcaaggg ccacgacggc      420

cuguaccagg gccugagcac cgccaccaag gacaccuacg acgcccugca caugcaggcc      480

cugcccccca gauga                                                       495


<210>  866
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD3Z__Homo_sapiens__AAH25703

<400>  866
augaagugga aagcccuguu caccgcugcc auccuccagg cgcaacugcc cauuacagag       60

gcucagagcu uuggccuucu ggacccuaag cucugcuacc ugcuugaugg gauccuguuc      120

auuuauggag ugauccucac ggcccuguuu cugagaguca aauucucccg gucugccgac      180

gcuccggccu accagcaggg ccaaaaccag cucuauaaug aacugaaccu ugggcgcaga      240

gaggaauacg auguucugga caagcggcgc ggaagagauc ccgagauggg cgggaaaccu      300

cagcggcgca agaaucccca ggaaggacuc uauaacgagc ugcaaaagga caaaauggcu      360

gaggccuaca gcgaaauugg caugaagggc gagagacggc gcgggaaagg acacgauggc      420

cuuuaucagg ggcuguccac cgcgacaaag gacaccuacg augcccucca uaugcaggcu      480

cugccuccca gauga                                                       495


<210>  867
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD44_Isoform_1__Homo_sapiens__P16070

<400>  867

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  868
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  868
auggacaagu uuugguggca cgcagccugg ggacucugcc ucgugccgcu gagccuggcg       60

cagaucgauu ugaauauaac cugccgcuuu gcagguguau uccacgugga gaaaaauggu      120

cgcuacagca ucucucggac ggaggccgcu gaccucugca aggcuuucaa uagcaccuug      180

cccacaaugg cccagaugga gaaagcucug agcaucggau uugagaccug cagguauggg      240

uucauagaag ggcacguggu gauuccccgg auccacccca acuccaucug ugcagcaaac      300

aacacagggg uguacauccu cacauccaac accucccagu augacacaua uugcuucaau      360

gcuucagcuc caccugaaga agauuguaca ucagucacag accugcccaa ugccuuugau      420

ggaccaauua ccauaacuau uguuaaccgu gauggcaccc gcuaugucca gaaaggagaa      480

uacagaacga auccugaaga caucuacccc agcaacccua cugaugauga cgugagcagc      540

ggcuccucca gugaaaggag cagcacuuca ggagguuaca ucuuuuacac cuuuucuacu      600

guacacccca ucccagacga agacaguccc uggaucaccg acagcacaga cagaaucccu      660

gcuaccacuu ugaugagcac uagugcuaca gcaacugaga cagcaaccaa gaggcaagaa      720

accugggauu gguuuucaug guuguuucua ccaucagagu caaagaauca ucuucacaca      780

acaacacaaa uggcugguac gucuucaaau accaucucag caggcuggga gccaaaugaa      840

gaaaaugaag augaaagaga cagacaccuc aguuuuucug gaucaggcau ugaugaugau      900

gaagauuuua ucuccagcac cauuucaacc acaccacggg cuuuugacca cacaaaacag      960

aaccaggacu ggacccagug gaacccaagc cauucaaauc cggaagugcu acuucagaca     1020

accacaagga ugacugaugu agacagaaau ggcaccacug cuuaugaagg aaacuggaac     1080

ccagaagcac acccuccccu cauucaccau gagcaucaug aggaagaaga gaccccacau     1140

ucuacaagca caauccaggc aacuccuagu aguacaacgg aagaaacagc uacccagaag     1200

gaacaguggu uuggcaacag auggcaugag ggauaucgcc aaacacccaa agaagacucc     1260

cauucgacaa cagggacagc ugcagccuca gcucauacca gccauccaau gcaaggaagg     1320

acaacaccaa gcccagagga caguuccugg acugauuucu ucaacccaau cucacacccc     1380

augggacgag gucaucaagc aggaagaagg auggauaugg acuccaguca uaguauaacg     1440

cuucagccua cugcaaaucc aaacacaggu uugguggaag auuuggacag gacaggaccu     1500

cuuucaauga caacgcagca gaguaauucu cagagcuucu cuacaucaca ugaaggcuug     1560

gaagaagaua aagaccaucc aacaacuucu acucugacau caagcaauag gaaugauguc     1620

acagguggaa gaagagaccc aaaucauucu gaaggcucaa cuacuuuacu ggaagguuau     1680

accucucauu acccacacac gaaggaaagc aggaccuuca ucccagugac cucagcuaag     1740

acuggguccu uuggaguuac ugcaguuacu guuggagauu ccaacucuaa ugucaaucgu     1800

uccuuaucag gagaccaaga cacauuccac cccagugggg ggucccauac cacucaugga     1860

ucugaaucag auggacacuc acaugggagu caagaaggug gagcaaacac aaccucuggu     1920

ccuauaagga caccccaaau uccagaaugg cugaucaucu uggcaucccu cuuggccuug     1980

gcuuugauuc uugcaguuug cauugcaguc aacagucgaa gaaggugugg gcagaagaaa     2040

aagcuaguga ucaacagugg caauggagcu guggaggaca gaaagccaag uggacucaac     2100

ggagaggcca gcaagucuca ggaaauggug cauuugguga acaaggaguc gucagaaacu     2160

ccagaccagu uuaugacagc ugaugagaca aggaaccugc agaaugugga caugaagauu     2220

gggguguaa                                                             2229


<210>  869
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  869
auggacaagu ucugguggca cgccgccugg ggccugugcc ucgugccccu gagccuggcg       60

cagaucgacc ucaacaucac gugccgcuuc gccggggucu uccacgugga gaagaacggc      120

cgguacucca ucagccgcac cgaggccgcc gaccugugca aggccuucaa cuccacccug      180

ccgaccaugg cgcagaugga gaaggcccuc agcaucgggu ucgagaccug ccgguacggc      240

uucaucgagg ggcacguggu caucccccgc auccacccca acuccaucug cgccgccaac      300

aacaccggcg uguacauccu gacgagcaac accucccagu acgacaccua cugcuucaac      360

gcgagcgcgc ccccggagga ggacugcacc uccgugacgg accugcccaa cgccuucgac      420

ggccccauca ccaucaccau cgucaaccgg gacgggaccc gcuacgugca gaagggcgag      480

uaccggacga accccgagga caucuacccg agcaacccca ccgacgacga cguguccagc      540

ggguccagcu ccgagcgcag cuccaccagc ggcggguaca ucuucuacac cuucuccacg      600

guccacccca uccccgacga ggacagcccg uggaucaccg acagcaccga ccggaucccc      660

gccaccacgc ucauguccac cagcgccacc gccaccgaga cggccaccaa gcgccaggag      720

accugggacu gguucuccug gcuguuccug cccagcgagu ccaagaacca ccuccacacc      780

acgacccaga uggccggcac cagcuccaac accaucagcg ccggcuggga gcccaacgag      840

gagaacgagg acgagcggga ccgccaccug uccuucagcg gguccggcau cgacgacgac      900

gaggacuuca ucagcuccac gaucagcacc accccgcggg ccuucgacca caccaagcag      960

aaccaggacu ggacgcagug gaaccccucc cacagcaacc ccgaggugcu gcuccagacc     1020

accacccgca ugaccgacgu ggaccggaac gggacgaccg cguacgaggg caacuggaac     1080

cccgaggccc acccgccccu gauccaccac gagcaccacg aggaggagga gacgccccac     1140

uccaccagca ccauccaggc cacccccucc agcaccaccg aggagacggc cacccagaag     1200

gagcaguggu ucggcaaccg cuggcacgag ggguaccggc agaccccgaa ggaggacagc     1260

cacuccacca cgggcaccgc cgcggccagc gcccacaccu cccaccccau gcaggggcgc     1320

accacgccca gccccgagga cuccagcugg accgacuucu ucaacccgau cucccacccc     1380

augggccggg ggcaccaggc cggccgccgg auggacaugg acagcuccca cagcaucacc     1440

cugcagccca ccgccaaccc gaacacgggc cucgucgagg accuggaccg caccgggccc     1500

cuguccauga ccacccagca gagcaacucc cagagcuucu ccacgagcca cgagggccuc     1560

gaggaggaca aggaccaccc caccaccucc acccugacga gcagcaaccg caacgacgug     1620

accgggggcc ggcgcgaccc caaccacucc gaggggagca ccacccugcu cgagggcuac     1680

acgucccacu acccgcacac caaggagagc cggaccuuca uccccgugac cuccgcgaag     1740

acgggcagcu ucggggucac cgccgugacc gugggcgacu ccaacagcaa cgucaaccgc     1800

ucccugagcg gggaccagga caccuuccac cccuccggcg ggagccacac cacgcacggc     1860

uccgagagcg acggccacuc ccacgggagc caggagggcg gggccaacac caccuccggc     1920

cccauccgga ccccgcagau ccccgagugg cugaucaucc ucgccagccu gcuggcgcuc     1980

gcccugaucc uggccgugug caucgccgug aacucccgcc ggcgcugcgg ccagaagaag     2040

aagcucguca ucaacagcgg gaacggcgcc guggaggacc ggaagcccag cgggcugaac     2100

ggcgaggcgu ccaagagcca ggagauggug caccugguca acaaggaguc cagcgagacg     2160

cccgaccagu ucaugaccgc cgacgagacc cgcaaccucc agaacgugga caugaagauc     2220

ggggucuga                                                             2229


<210>  870
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  870
auggacaagu ucugguggca cgccgccugg ggccucugcc ucgucccccu cucccucgcc       60

cagaucgacc ucaacaucac cugccgcuuc gccggcgucu uccacgucga gaagaacggc      120

cgcuacucca ucucccgcac cgaggccgcc gaccucugca aggccuucaa cuccacccuc      180

cccaccaugg cccagaugga gaaggcccuc uccaucggcu ucgagaccug ccgcuacggc      240

uucaucgagg gccacgucgu caucccccgc auccacccca acuccaucug cgccgccaac      300

aacaccggcg ucuacauccu caccuccaac accucccagu acgacaccua cugcuucaac      360

gccuccgccc cccccgagga ggacugcacc uccgucaccg accuccccaa cgccuucgac      420

ggccccauca ccaucaccau cgucaaccgc gacggcaccc gcuacgucca gaagggcgag      480

uaccgcacca accccgagga caucuacccc uccaacccca ccgacgacga cgucuccucc      540

ggcuccuccu ccgagcgcuc cuccaccucc ggcggcuaca ucuucuacac cuucuccacc      600

guccacccca uccccgacga ggacuccccc uggaucaccg acuccaccga ccgcaucccc      660

gccaccaccc ucauguccac cuccgccacc gccaccgaga ccgccaccaa gcgccaggag      720

accugggacu gguucuccug gcucuuccuc cccuccgagu ccaagaacca ccuccacacc      780

accacccaga uggccggcac cuccuccaac accaucuccg ccggcuggga gcccaacgag      840

gagaacgagg acgagcgcga ccgccaccuc uccuucuccg gcuccggcau cgacgacgac      900

gaggacuuca ucuccuccac caucuccacc accccccgcg ccuucgacca caccaagcag      960

aaccaggacu ggacccagug gaaccccucc cacuccaacc ccgagguccu ccuccagacc     1020

accacccgca ugaccgacgu cgaccgcaac ggcaccaccg ccuacgaggg caacuggaac     1080

cccgaggccc accccccccu cauccaccac gagcaccacg aggaggagga gaccccccac     1140

uccaccucca ccauccaggc cacccccucc uccaccaccg aggagaccgc cacccagaag     1200

gagcaguggu ucggcaaccg cuggcacgag ggcuaccgcc agacccccaa ggaggacucc     1260

cacuccacca ccggcaccgc cgccgccucc gcccacaccu cccaccccau gcagggccgc     1320

accacccccu cccccgagga cuccuccugg accgacuucu ucaaccccau cucccacccc     1380

augggccgcg gccaccaggc cggccgccgc auggacaugg acuccuccca cuccaucacc     1440

cuccagccca ccgccaaccc caacaccggc cucgucgagg accucgaccg caccggcccc     1500

cucuccauga ccacccagca guccaacucc caguccuucu ccaccuccca cgagggccuc     1560

gaggaggaca aggaccaccc caccaccucc acccucaccu ccuccaaccg caacgacguc     1620

accggcggcc gccgcgaccc caaccacucc gagggcucca ccacccuccu cgagggcuac     1680

accucccacu acccccacac caaggagucc cgcaccuuca uccccgucac cuccgccaag     1740

accggcuccu ucggcgucac cgccgucacc gucggcgacu ccaacuccaa cgucaaccgc     1800

ucccucuccg gcgaccagga caccuuccac cccuccggcg gcucccacac cacccacggc     1860

uccgaguccg acggccacuc ccacggcucc caggagggcg gcgccaacac caccuccggc     1920

cccauccgca ccccccagau ccccgagugg cucaucaucc ucgccucccu ccucgcccuc     1980

gcccucaucc ucgccgucug caucgccguc aacucccgcc gccgcugcgg ccagaagaag     2040

aagcucguca ucaacuccgg caacggcgcc gucgaggacc gcaagcccuc cggccucaac     2100

ggcgaggccu ccaaguccca ggagaugguc caccucguca acaaggaguc cuccgagacc     2160

cccgaccagu ucaugaccgc cgacgagacc cgcaaccucc agaacgucga caugaagauc     2220

ggcgucuga                                                             2229


<210>  871
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  871
auggacaagu ucugguggca cgccgcuugg ggccugugcc ucgugccccu uagccuggca       60

cagaucgauu ugaacauuac cuguagauuu gccggggucu uccauguuga gaaaaaugga      120

agguacucca uaucucggac agaagcggcu gacuuaugca aggccuuuaa cucaacucug      180

ccuacgaugg cacaaaugga gaaagcccua aguaucgguu ucgaaaccug ucgcuauggc      240

uuuauugagg ggcacguggu aaucccacgu auucauccga auagcaucug cgcugcaaac      300

aauacaggag uguacauacu cacuuccaac accucucagu augauacaua cuguuucaau      360

gccucggcuc ccccugaaga ggacugcacc ucagucacug aucugccaaa cgccuuugac      420

ggccccauca caauuaccau cgugaaucga gaugguacga gauauguuca gaagggggag      480

uacaggacua acccugaaga cauuuaucca agcaauccca ccgaugacga ugugaguucc      540

ggaucuagcu ccgagcgguc aaguacaagc ggcggcuaca ucuucuacac uuuuucuacc      600

guccacccua uaccagacga agauuccccg uggauuacag acucaaccga ccgcaucccc      660

gcgacgacuc uuaugagcac aagugcaacc gccacugaga cagcuaccaa aagacaggag      720

acgugggauu gguucucuug gcuguuuuug ccuuccgaaa gcaagaacca ucuccacacc      780

acaacucaaa uggccgggac cucgucuaau acaauuuccg caggauggga gccaaacgaa      840

gagaaugaag acgagaggga ucggcaccug ucauucagug guagcggcau cgacgaugac      900

gaggauuuua ucuccucuac uauuagcacc acaccccgcg cuuucgacca uaccaagcag      960

aaccaggauu ggacucagug gaacccuuca cacaguaauc cagaagugcu gcuccaaacg     1020

acaacccgaa ugacugacgu agauagaaac gggaccacag ccuaugaggg aaauuggaac     1080

cccgaagcgc auccgccuuu aauacaccac gagcaucacg aagaggagga aacuccccau     1140

uccacuagca caauccaggc cacgccaucu ucaaccacug aggaaacagc aacccagaaa     1200

gagcaguggu ucggcaauag guggcacgaa gguuaccggc aaacaccuaa ggaggacagu     1260

cauagcacua ccgggacggc ugccgcuucc gcccacaccu cucaccccau gcagggacgu     1320

acaacuccau cgcccgagga cagcuccugg accgacuuuu ucaacccuau uucacaucca     1380

augggccgcg gccaccaggc agggagaagg auggauaugg auaguucuca uagcaucaca     1440

cugcaaccga cugccaaucc caacaccgga cuuguugaag acuuggaucg gacggguccu     1500

cuguccauga caacccagca gucaaauagc cagucuuuuu ccaccaguca cgagggccua     1560

gaagaggaca aagaucaccc aacaaccagc acucucaccu cuuccaaccg aaaugacgug     1620

acagggggac gcagagaucc caaccauuca gagggcagua cgacccugcu ugaagguuau     1680

acuagccacu acccucauac aaaggagucg aggaccuuca uaccagucac auccgcuaaa     1740

acugggucuu uuggcgugac cgcggugacg gucggagaca gcaauucaaa cguuaaucgg     1800

agucuguccg gcgaucaaga cacauuccac cccucugggg gaagccauac cacucacggu     1860

uccgaaucag auggccacag ccaugggagu caggagggag gcgcaaacac cacaucuggu     1920

ccgauucgca cuccucagau cccagaaugg uugaucauuc ucgccucccu guuagcucug     1980

gcccucaucc uugcagugug uauugccgua aacagcagaa ggcguugcgg gcagaagaag     2040

aaacugguga uaaauucggg caacggagcu gucgaggacc ggaagcccuc aggcuugaau     2100

ggggaggccu cuaaaaguca agaaauggug caccuaguua acaaggaguc cagcgaaacc     2160

ccugaccagu uuaugacagc agaugagacg cgaaaucugc agaacgugga caugaaaauc     2220

ggagucuga                                                             2229


<210>  872
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  872
auggacaagu ucugguggca cgccgccugg ggccugugcc uggugccccu gagccuggcc       60

cagaucgacc ugaacaucac cugcagauuc gccggcgugu uccacgugga gaagaacggc      120

agauacagca ucagcagaac cgaggccgcc gaccugugca aggccuucaa cagcacccug      180

cccaccaugg cccagaugga gaaggcccug agcaucggcu ucgagaccug cagauacggc      240

uucaucgagg gccacguggu gauccccaga auccacccca acagcaucug cgccgccaac      300

aacaccggcg uguacauccu gaccagcaac accagccagu acgacaccua cugcuucaac      360

gccagcgccc cccccgagga ggacugcacc agcgugaccg accugcccaa cgccuucgac      420

ggccccauca ccaucaccau cgugaacaga gacggcacca gauacgugca gaagggcgag      480

uacagaacca accccgagga caucuacccc agcaacccca ccgacgacga cgugagcagc      540

ggcagcagca gcgagagaag cagcaccagc ggcggcuaca ucuucuacac cuucagcacc      600

gugcacccca uccccgacga ggacagcccc uggaucaccg acagcaccga cagaaucccc      660

gccaccaccc ugaugagcac cagcgccacc gccaccgaga ccgccaccaa gagacaggag      720

accugggacu gguucagcug gcuguuccug cccagcgaga gcaagaacca ccugcacacc      780

accacccaga uggccggcac cagcagcaac accaucagcg ccggcuggga gcccaacgag      840

gagaacgagg acgagagaga cagacaccug agcuucagcg gcagcggcau cgacgacgac      900

gaggacuuca ucagcagcac caucagcacc acccccagag ccuucgacca caccaagcag      960

aaccaggacu ggacccagug gaaccccagc cacagcaacc ccgaggugcu gcugcagacc     1020

accaccagaa ugaccgacgu ggacagaaac ggcaccaccg ccuacgaggg caacuggaac     1080

cccgaggccc accccccccu gauccaccac gagcaccacg aggaggagga gaccccccac     1140

agcaccagca ccauccaggc cacccccagc agcaccaccg aggagaccgc cacccagaag     1200

gagcaguggu ucggcaacag auggcacgag ggcuacagac agacccccaa ggaggacagc     1260

cacagcacca ccggcaccgc cgccgccagc gcccacacca gccaccccau gcagggcaga     1320

accaccccca gccccgagga cagcagcugg accgacuucu ucaaccccau cagccacccc     1380

augggcagag gccaccaggc cggcagaaga auggacaugg acagcagcca cagcaucacc     1440

cugcagccca ccgccaaccc caacaccggc cugguggagg accuggacag aaccggcccc     1500

cugagcauga ccacccagca gagcaacagc cagagcuuca gcaccagcca cgagggccug     1560

gaggaggaca aggaccaccc caccaccagc acccugacca gcagcaacag aaacgacgug     1620

accggcggca gaagagaccc caaccacagc gagggcagca ccacccugcu ggagggcuac     1680

accagccacu acccccacac caaggagagc agaaccuuca uccccgugac cagcgccaag     1740

accggcagcu ucggcgugac cgccgugacc gugggcgaca gcaacagcaa cgugaacaga     1800

agccugagcg gcgaccagga caccuuccac cccagcggcg gcagccacac cacccacggc     1860

agcgagagcg acggccacag ccacggcagc caggagggcg gcgccaacac caccagcggc     1920

cccaucagaa ccccccagau ccccgagugg cugaucaucc uggccagccu gcuggcccug     1980

gcccugaucc uggccgugug caucgccgug aacagcagaa gaagaugcgg ccagaagaag     2040

aagcugguga ucaacagcgg caacggcgcc guggaggaca gaaagcccag cggccugaac     2100

ggcgaggcca gcaagagcca ggagauggug caccugguga acaaggagag cagcgagacc     2160

cccgaccagu ucaugaccgc cgacgagacc agaaaccugc agaacgugga caugaagauc     2220

ggcguguga                                                             2229


<210>  873
<211>  2229
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD44_Isoform_1__Homo_sapiens__CCDS7897.1

<400>  873
auggacaagu ucugguggca cgccgcuugg ggccugugcc ucgugccccu gagccuugcc       60

cagaucgauc ugaacauuac cuguagauuu gcgggggucu uccauguuga gaaaaaugga      120

cgguacucca ucucucgcac agaagcugcc gaccucugca aggccuuuaa cagcacgcug      180

ccuaccaugg cucaaaugga gaaagcccuu uccauuggcu ucgaaacaug uagauauggg      240

uuuaucgagg gacacguggu gauuccgcgg auccauccca auucuaucug cgcugccaac      300

aauaccggcg ucuacauucu gacaagcaac accucccagu augauacaua cuguuucaau      360

gcgucugccc cucccgaaga ggacugcacc agcgugacgg aucucccuaa cgcuuuugac      420

gggcccauca ccauuacaau cguuaaucgc gauggaacca gauaugugca gaagggcgag      480

uaccggacaa acccugaaga cauuuauccg uccaauccca ccgaugacga ugucagcucu      540

ggcuccagcu cugagcgcuc cagcacgucu gggggauaca ucuucuacac auuuuccacc      600

gugcacccua uucccgacga agauagcccu uggaucacag acuccaccga cagaaucccc      660

gccaccacac ugaugucuac gagcgcuacc gccacagaga ccgcgacaaa acggcaggag      720

accugggauu gguucuccug gcuguuucuc ccgagcgaau cuaagaacca ucugcacacg      780

acaacccaaa uggccggcac cuccagcaau acaauuucug cuggguggga gccuaacgaa      840

gagaaugaag acgagcgcga uagacaccuu agcuucuccg gaucuggcau cgacgaugac      900

gaggauuuua uuagcuccac caucagcaca acgccccggg ccuucgacca uaccaagcag      960

aaccaggauu ggacacagug gaacccuucu cacuccaauc ccgaaguucu gcuccaaacc     1020

acaacccgca ugacggacgu ggauagaaac gggaccacag cuuaugaggg aaauuggaac     1080

cccgaagccc auccuccgcu gauucaccac gagcaucacg aagaggagga aacaccccau     1140

agcaccucua ccauccaggc cacgccuucc agcacaaccg aggaaacagc uacccagaaa     1200

gagcaguggu ucggcaaucg guggcacgaa ggcuaccgcc aaacccccaa ggaggacucc     1260

cauucuacaa cggggaccgc ggccgcuagc gcccacacau cccacccuau gcagggaaga     1320

accacacccu cuccggagga cagcuccugg accgacuuuu ucaacccuau cagccauccc     1380

augggccggg ggcaccaggc cggaagacgc auggauaugg auucuuccca uagcauuacg     1440

cuucaaccua cagcuaaucc caacaccggc cuggucgaag accucgaucg gaccgggccu     1500

cugucuauga caacccagca guccaauagc cagucuuuua gcacauccca cgagggacug     1560

gaagaggaca aagaucaccc cacgaccagc acacucaccu cuuccaacag aaaugacgug     1620

acaggcggcc gccgggaucc gaaccauagc gaggggucca ccacgcugcu ugaaggauau     1680

accucucacu acccucauac aaaggagagc agaaccuuca uccccgugac auccgccaaa     1740

accggcucuu uuggggucac agcgguuacc gugggagaca gcaauuccaa cgugaaucgc     1800

ucucugagcg gcgaucaaga cacguuccac cccuccgggg gcagccauac aacccacgga     1860

ucugaauccg auggccacag ccaugggucu caggagggag gcgcuaacac cacauccggg     1920

ccuauucgga ccccgcagau ccccgaaugg cucauuaucc uggccagccu ucuggcccuc     1980

gcucugaucc uggccgucug uauugcugug aacucuagac gccggugcgg acagaagaag     2040

aaacucguua ucaauuccgg caacggggcc guggaggaca gaaagccuag cggccugaau     2100

ggagaggcgu ccaaaagcca agaaaugguc caccuuguga acaaggaguc uagcgaaacg     2160

cccgaccagu uuaugacagc cgaugagacc cgcaaucugc agaacguuga caugaaaauu     2220

ggcguguga                                                             2229


<210>  874
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD44_Isoform_6__Homo_sapiens__P16070-6

<400>  874

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Thr Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  875
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  875
auggacaagu uuugguggca cgcagccugg ggacucugcc ucgugccgcu gagccuggcg       60

cagaucgauu ugaauauaac cugccgcuuu gcagguguau uccacgugga gaaaaauggu      120

cgcuacagca ucucucggac ggaggccgcu gaccucugca aggcuuucaa uagcaccuug      180

cccacaaugg cccagaugga gaaagcucug agcaucggau uugagaccug cagguauggg      240

uucauagaag ggcacguggu gauuccccgg auccacccca acuccaucug ugcagcaaac      300

aacacagggg uguacauccu cacauccaac accucccagu augacacaua uugcuucaau      360

gcuucagcuc caccugaaga agauuguaca ucagucacag accugcccaa ugccuuugau      420

ggaccaauua ccauaacuau uguuaaccgu gauggcaccc gcuaugucca gaaaggagaa      480

uacagaacga auccugaaga caucuacccc agcaacccua cugaugauga cgugagcagc      540

ggcuccucca gugaaaggag cagcacuuca ggagguuaca ucuuuuacac cuuuucuacu      600

guacacccca ucccagacga agacaguccc uggaucaccg acagcacaga cagaaucccu      660

gcuaccacuu ugaugagcac uagugcuaca gcaacugaga cagcaaccaa gaggcaagaa      720

accugggauu gguuuucaug guuguuucua ccaucagagu caaagaauca ucuucacaca      780

acaacacaaa uggcugguac gucuucaaau accaucucag caggcuggga gccaaaugaa      840

gaaaaugaag augaaagaga cagacaccuc aguuuuucug gaucaggcau ugaugaugau      900

gaagauuuua ucuccagcac cauuucaacc acaccacggg cuuuugacca cacaaaacag      960

aaccaggacu ggacccagug gaacccaagc cauucaaauc cggaagugcu acuucagaca     1020

accacaagga ugacugaugu agacagaaau ggcaccacug cuuaugaagg aaacuggaac     1080

ccagaagcac acccuccccu cauucaccau gagcaucaug aggaagaaga gaccccacau     1140

ucuacaagca caacagcuuc agcucauacc agccauccaa ugcaaggaag gacaacacca     1200

agcccagagg acaguuccug gacugauuuc uucaacccaa ucucacaccc caugggacga     1260

ggucaucaag caggaagaag gauggauaug gacuccaguc auaguauaac gcuucagccu     1320

acugcaaauc caaacacagg uuugguggaa gauuuggaca ggacaggacc ucuuucaaug     1380

acaacgcagc agaguaauuc ucagagcuuc ucuacaucac augaaggcuu ggaagaagau     1440

aaagaccauc caacaacuuc uacucugaca ucaagcaaua ggaaugaugu cacaggugga     1500

agaagagacc caaaucauuc ugaaggcuca acuacuuuac uggaagguua uaccucucau     1560

uacccacaca cgaaggaaag caggaccuuc aucccaguga ccucagcuaa gacugggucc     1620

uuuggaguua cugcaguuac uguuggagau uccaacucua augucaaucg uuccuuauca     1680

ggagaccaag acacauucca ccccaguggg gggucccaua ccacucaugg aucugaauca     1740

gauggacacu cacaugggag ucaagaaggu ggagcaaaca caaccucugg uccuauaagg     1800

acaccccaaa uuccagaaug gcugaucauc uuggcauccc ucuuggccuu ggcuuugauu     1860

cuugcaguuu gcauugcagu caacagucga agaaggugug ggcagaagaa aaagcuagug     1920

aucaacagug gcaauggagc uguggaggac agaaagccaa guggacucaa cggagaggcc     1980

agcaagucuc aggaaauggu gcauuuggug aacaaggagu cgucagaaac uccagaccag     2040

uuuaugacag cugaugagac aaggaaccug cagaaugugg acaugaagau ugggguguaa     2100


<210>  876
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  876
auggacaagu ucugguggca cgccgccugg ggccugugcc ucgugccccu gagccuggcg       60

cagaucgacc ucaacaucac gugccgcuuc gccggggucu uccacgugga gaagaacggc      120

cgguacucca ucagccgcac cgaggccgcc gaccugugca aggccuucaa cuccacccug      180

ccgaccaugg cgcagaugga gaaggcccuc agcaucgggu ucgagaccug ccgguacggc      240

uucaucgagg ggcacguggu caucccccgc auccacccca acuccaucug cgccgccaac      300

aacaccggcg uguacauccu gacgagcaac accucccagu acgacaccua cugcuucaac      360

gcgagcgcgc ccccggagga ggacugcacc uccgugacgg accugcccaa cgccuucgac      420

ggccccauca ccaucaccau cgucaaccgg gacgggaccc gcuacgugca gaagggcgag      480

uaccggacga accccgagga caucuacccg agcaacccca ccgacgacga cguguccagc      540

ggguccagcu ccgagcgcag cuccaccagc ggcggguaca ucuucuacac cuucuccacg      600

guccacccca uccccgacga ggacagcccg uggaucaccg acagcaccga ccggaucccc      660

gccaccacgc ucauguccac cagcgccacc gccaccgaga cggccaccaa gcgccaggag      720

accugggacu gguucuccug gcuguuccug cccagcgagu ccaagaacca ccuccacacc      780

acgacccaga uggccggcac cagcuccaac accaucagcg ccggcuggga gcccaacgag      840

gagaacgagg acgagcggga ccgccaccug uccuucagcg gguccggcau cgacgacgac      900

gaggacuuca ucagcuccac gaucagcacc accccgcggg ccuucgacca caccaagcag      960

aaccaggacu ggacgcagug gaaccccucc cacagcaacc ccgaggugcu gcuccagacc     1020

accacccgca ugaccgacgu ggaccggaac gggacgaccg cguacgaggg caacuggaac     1080

cccgaggccc acccgccccu gauccaccac gagcaccacg aggaggagga gacgccccac     1140

uccaccagca ccaccgccuc cgcccacacc agccacccca ugcagggccg caccacgccg     1200

agccccgagg acuccagcug gaccgacuuc uucaacccca ucucccaccc cauggggcgg     1260

ggccaccagg ccgggcgccg gauggacaug gacagcuccc acagcaucac ccugcagccg     1320

accgcgaacc ccaacacggg ccucgucgag gaccuggacc gcaccgggcc ccuguccaug     1380

accacccagc agagcaacuc ccagagcuuc uccacgagcc acgagggccu cgaggaggac     1440

aaggaccacc cgaccaccuc cacccugacg agcuccaacc ggaacgacgu gaccggcggg     1500

cgccgcgacc ccaaccacag cgagggcucc accacccugc ucgaggggua cacgagccac     1560

uacccccaca ccaaggagag ccggaccuuc auccccguga ccuccgccaa gacgggcagc     1620

uucgggguca ccgccgugac cgugggcgac uccaacagca acgucaaccg cucccugagc     1680

ggcgaccagg acaccuucca cccguccggg ggcagccaca cgacccacgg guccgagagc     1740

gacggccacu cccacgggag ccaggagggc ggcgccaaca ccaccuccgg gcccauccgg     1800

acgccccaga uccccgagug gcugaucauc cucgccagcc ugcuggcgcu cgcccugauc     1860

cuggccgugu gcaucgccgu gaacucccgc cggcgcugcg gccagaagaa gaagcucguc     1920

aucaacagcg ggaacggcgc gguggaggac cggaagccgu ccggccugaa cggggaggcc     1980

agcaaguccc aggagauggu gcaccugguc aacaaggaga gcagcgagac ccccgaccag     2040

uucaugaccg ccgacgagac ccgcaaccuc cagaacgugg acaugaagau cggcgucuga     2100


<210>  877
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  877
auggacaagu ucugguggca cgccgccugg ggccucugcc ucgucccccu cucccucgcc       60

cagaucgacc ucaacaucac cugccgcuuc gccggcgucu uccacgucga gaagaacggc      120

cgcuacucca ucucccgcac cgaggccgcc gaccucugca aggccuucaa cuccacccuc      180

cccaccaugg cccagaugga gaaggcccuc uccaucggcu ucgagaccug ccgcuacggc      240

uucaucgagg gccacgucgu caucccccgc auccacccca acuccaucug cgccgccaac      300

aacaccggcg ucuacauccu caccuccaac accucccagu acgacaccua cugcuucaac      360

gccuccgccc cccccgagga ggacugcacc uccgucaccg accuccccaa cgccuucgac      420

ggccccauca ccaucaccau cgucaaccgc gacggcaccc gcuacgucca gaagggcgag      480

uaccgcacca accccgagga caucuacccc uccaacccca ccgacgacga cgucuccucc      540

ggcuccuccu ccgagcgcuc cuccaccucc ggcggcuaca ucuucuacac cuucuccacc      600

guccacccca uccccgacga ggacuccccc uggaucaccg acuccaccga ccgcaucccc      660

gccaccaccc ucauguccac cuccgccacc gccaccgaga ccgccaccaa gcgccaggag      720

accugggacu gguucuccug gcucuuccuc cccuccgagu ccaagaacca ccuccacacc      780

accacccaga uggccggcac cuccuccaac accaucuccg ccggcuggga gcccaacgag      840

gagaacgagg acgagcgcga ccgccaccuc uccuucuccg gcuccggcau cgacgacgac      900

gaggacuuca ucuccuccac caucuccacc accccccgcg ccuucgacca caccaagcag      960

aaccaggacu ggacccagug gaaccccucc cacuccaacc ccgagguccu ccuccagacc     1020

accacccgca ugaccgacgu cgaccgcaac ggcaccaccg ccuacgaggg caacuggaac     1080

cccgaggccc accccccccu cauccaccac gagcaccacg aggaggagga gaccccccac     1140

uccaccucca ccaccgccuc cgcccacacc ucccacccca ugcagggccg caccaccccc     1200

ucccccgagg acuccuccug gaccgacuuc uucaacccca ucucccaccc caugggccgc     1260

ggccaccagg ccggccgccg cauggacaug gacuccuccc acuccaucac ccuccagccc     1320

accgccaacc ccaacaccgg ccucgucgag gaccucgacc gcaccggccc ccucuccaug     1380

accacccagc aguccaacuc ccaguccuuc uccaccuccc acgagggccu cgaggaggac     1440

aaggaccacc ccaccaccuc cacccucacc uccuccaacc gcaacgacgu caccggcggc     1500

cgccgcgacc ccaaccacuc cgagggcucc accacccucc ucgagggcua caccucccac     1560

uacccccaca ccaaggaguc ccgcaccuuc auccccguca ccuccgccaa gaccggcucc     1620

uucggcguca ccgccgucac cgucggcgac uccaacucca acgucaaccg cucccucucc     1680

ggcgaccagg acaccuucca ccccuccggc ggcucccaca ccacccacgg cuccgagucc     1740

gacggccacu cccacggcuc ccaggagggc ggcgccaaca ccaccuccgg ccccauccgc     1800

accccccaga uccccgagug gcucaucauc cucgccuccc uccucgcccu cgcccucauc     1860

cucgccgucu gcaucgccgu caacucccgc cgccgcugcg gccagaagaa gaagcucguc     1920

aucaacuccg gcaacggcgc cgucgaggac cgcaagcccu ccggccucaa cggcgaggcc     1980

uccaaguccc aggagauggu ccaccucguc aacaaggagu ccuccgagac ccccgaccag     2040

uucaugaccg ccgacgagac ccgcaaccuc cagaacgucg acaugaagau cggcgucuga     2100


<210>  878
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  878
auggacaagu ucugguggca cgccgcuugg ggccugugcc ucgugccccu uagccuggca       60

cagaucgauu ugaacauuac cuguagauuu gccggggucu uccauguuga gaaaaaugga      120

agguacucca uaucucggac agaagcggcu gacuuaugca aggccuuuaa cucaacucug      180

ccuacgaugg cacaaaugga gaaagcccua aguaucgguu ucgaaaccug ucgcuauggc      240

uuuauugagg ggcacguggu aaucccacgu auucauccga auagcaucug cgcugcaaac      300

aauacaggag uguacauacu cacuuccaac accucucagu augauacaua cuguuucaau      360

gccucggcuc ccccugaaga ggacugcacc ucagucacug aucugccaaa cgccuuugac      420

ggccccauca caauuaccau cgugaaucga gaugguacga gauauguuca gaagggggag      480

uacaggacua acccugaaga cauuuaucca agcaauccca ccgaugacga ugugaguucc      540

ggaucuagcu ccgagcgguc aaguacaagc ggcggcuaca ucuucuacac uuuuucuacc      600

guccacccua uaccagacga agauuccccg uggauuacag acucaaccga ccgcaucccc      660

gcgacgacuc uuaugagcac aagugcaacc gccacugaga cagcuaccaa aagacaggag      720

acgugggauu gguucucuug gcuguuuuug ccuuccgaaa gcaagaacca ucuccacacc      780

acaacucaaa uggccgggac cucgucuaau acaauuuccg caggauggga gccaaacgaa      840

gagaaugaag acgagaggga ucggcaccug ucauucagug guagcggcau cgacgaugac      900

gaggauuuua ucuccucuac uauuagcacc acaccccgcg cuuucgacca uaccaagcag      960

aaccaggauu ggacucagug gaacccuuca cacaguaauc cagaagugcu gcuccaaacg     1020

acaacccgaa ugacugacgu agauagaaac gggaccacag ccuaugaggg aaauuggaac     1080

cccgaagcgc auccgccuuu aauacaccac gagcaucacg aagaggagga aacuccccau     1140

uccaccagca caacggccuc ugcacacacc ucacauccaa ugcagggcag gacuacaccu     1200

agucccgagg acagcuccug gaccgacuuc uuuaauccaa ucucucaccc caugggucgg     1260

gggcaccagg cuggacgucg cauggauaug gacucgagcc auuccauuac acugcagccu     1320

acugccaacc caaauaccgg ccuuguugaa gauuuggaca gaacgggccc gcugucaaug     1380

accacacaac agaguaacuc ucagagcuuc uccacuucac acgaggggcu agaagaggau     1440

aaagaccauc ccaccacaag cacucucacc ucuuccaaua ggaacgaugu gacgggaggu     1500

cggcgagacc cuaaucacag ugagggcagc acaacccugc uugaagggua cacuucucac     1560

uauccacaua caaaggaguc ccgcaccuuu auccccguca cuucagcuaa aaccggaagu     1620

uucggcguga cagccgugac ggucggugau agcaacucga auguuaacag aucccugucu     1680

ggggaccaag auaccuuuca cccuagcggc ggaucacaua cuacacacgg cagugaaucc     1740

gacgggcauu cucacggaag ccaggagggu ggcgcaaaua ccacauccgg gccaauaagg     1800

acuccccaga uuccggagug guugaucauc cucgccucac uguuagcucu ggcgcucauu     1860

cuugcagugu guaucgccgu aaacagccgg cgcagaugcg gacagaagaa aaagcuggug     1920

auuaacagug gcaauggugc ugucgaagau aggaagccuu cuggguugaa cggcgaggcc     1980

uccaaaagcc aagaaauggu gcaccuaguu aauaaggagu cgucagaaac cccagaccag     2040

uucaugacgg cagacgagac acguaaccug cagaaugugg auaugaaaau aggagucuga     2100


<210>  879
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  879
auggacaagu ucugguggca cgccgccugg ggccugugcc uggugccccu gagccuggcc       60

cagaucgacc ugaacaucac cugcagauuc gccggcgugu uccacgugga gaagaacggc      120

agauacagca ucagcagaac cgaggccgcc gaccugugca aggccuucaa cagcacccug      180

cccaccaugg cccagaugga gaaggcccug agcaucggcu ucgagaccug cagauacggc      240

uucaucgagg gccacguggu gauccccaga auccacccca acagcaucug cgccgccaac      300

aacaccggcg uguacauccu gaccagcaac accagccagu acgacaccua cugcuucaac      360

gccagcgccc cccccgagga ggacugcacc agcgugaccg accugcccaa cgccuucgac      420

ggccccauca ccaucaccau cgugaacaga gacggcacca gauacgugca gaagggcgag      480

uacagaacca accccgagga caucuacccc agcaacccca ccgacgacga cgugagcagc      540

ggcagcagca gcgagagaag cagcaccagc ggcggcuaca ucuucuacac cuucagcacc      600

gugcacccca uccccgacga ggacagcccc uggaucaccg acagcaccga cagaaucccc      660

gccaccaccc ugaugagcac cagcgccacc gccaccgaga ccgccaccaa gagacaggag      720

accugggacu gguucagcug gcuguuccug cccagcgaga gcaagaacca ccugcacacc      780

accacccaga uggccggcac cagcagcaac accaucagcg ccggcuggga gcccaacgag      840

gagaacgagg acgagagaga cagacaccug agcuucagcg gcagcggcau cgacgacgac      900

gaggacuuca ucagcagcac caucagcacc acccccagag ccuucgacca caccaagcag      960

aaccaggacu ggacccagug gaaccccagc cacagcaacc ccgaggugcu gcugcagacc     1020

accaccagaa ugaccgacgu ggacagaaac ggcaccaccg ccuacgaggg caacuggaac     1080

cccgaggccc accccccccu gauccaccac gagcaccacg aggaggagga gaccccccac     1140

agcaccagca ccaccgccag cgcccacacc agccacccca ugcagggcag aaccaccccc     1200

agccccgagg acagcagcug gaccgacuuc uucaacccca ucagccaccc caugggcaga     1260

ggccaccagg ccggcagaag aauggacaug gacagcagcc acagcaucac ccugcagccc     1320

accgccaacc ccaacaccgg ccugguggag gaccuggaca gaaccggccc ccugagcaug     1380

accacccagc agagcaacag ccagagcuuc agcaccagcc acgagggccu ggaggaggac     1440

aaggaccacc ccaccaccag cacccugacc agcagcaaca gaaacgacgu gaccggcggc     1500

agaagagacc ccaaccacag cgagggcagc accacccugc uggagggcua caccagccac     1560

uacccccaca ccaaggagag cagaaccuuc auccccguga ccagcgccaa gaccggcagc     1620

uucggcguga ccgccgugac cgugggcgac agcaacagca acgugaacag aagccugagc     1680

ggcgaccagg acaccuucca ccccagcggc ggcagccaca ccacccacgg cagcgagagc     1740

gacggccaca gccacggcag ccaggagggc ggcgccaaca ccaccagcgg ccccaucaga     1800

accccccaga uccccgagug gcugaucauc cuggccagcc ugcuggcccu ggcccugauc     1860

cuggccgugu gcaucgccgu gaacagcaga agaagaugcg gccagaagaa gaagcuggug     1920

aucaacagcg gcaacggcgc cguggaggac agaaagccca gcggccugaa cggcgaggcc     1980

agcaagagcc aggagauggu gcaccuggug aacaaggaga gcagcgagac ccccgaccag     2040

uucaugaccg ccgacgagac cagaaaccug cagaacgugg acaugaagau cggcguguga     2100


<210>  880
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD44_Isoform_6__Homo_sapiens__XM_006718388.1

<400>  880
auggacaagu ucugguggca cgccgcuugg ggccugugcc ucgugccccu gagccuugcc       60

cagaucgauc ugaacauuac cuguagauuu gcgggggucu uccauguuga gaaaaaugga      120

cgguacucca ucucucgcac agaagcugcc gaccucugca aggccuuuaa cagcacgcug      180

ccuaccaugg cucaaaugga gaaagcccuu uccauuggcu ucgaaacaug uagauauggg      240

uuuaucgagg gacacguggu gauuccgcgg auccauccca auucuaucug cgcugccaac      300

aauaccggcg ucuacauucu gacaagcaac accucccagu augauacaua cuguuucaau      360

gcgucugccc cucccgaaga ggacugcacc agcgugacgg aucucccuaa cgcuuuugac      420

gggcccauca ccauuacaau cguuaaucgc gauggaacca gauaugugca gaagggcgag      480

uaccggacaa acccugaaga cauuuauccg uccaauccca ccgaugacga ugucagcucu      540

ggcuccagcu cugagcgcuc cagcacgucu gggggauaca ucuucuacac auuuuccacc      600

gugcacccua uucccgacga agauagcccu uggaucacag acuccaccga cagaaucccc      660

gccaccacac ugaugucuac gagcgcuacc gccacagaga ccgcgacaaa acggcaggag      720

accugggauu gguucuccug gcuguuucuc ccgagcgaau cuaagaacca ucugcacacg      780

acaacccaaa uggccggcac cuccagcaau acaauuucug cuggguggga gccuaacgaa      840

gagaaugaag acgagcgcga uagacaccuu agcuucuccg gaucuggcau cgacgaugac      900

gaggauuuua uuagcuccac caucagcaca acgccccggg ccuucgacca uaccaagcag      960

aaccaggauu ggacacagug gaacccuucu cacuccaauc ccgaaguucu gcuccaaacc     1020

acaacccgca ugacggacgu ggauagaaac gggaccacag cuuaugaggg aaauuggaac     1080

cccgaagccc auccuccgcu gauucaccac gagcaucacg aagaggagga aacaccccau     1140

agcaccucua ccacggccuc cgcucacaca agccauccua ugcagggccg gaccacaccc     1200

uccccugagg acucuagcug gaccgacuuc uuuaauccca ucucccaccc gaugggccgc     1260

gggcaccagg cgggaagacg gauggauaug gacucuagcc auuccaucac ccuucagccu     1320

acagccaacc ccaauacggg ccuggucgaa gaucucgaca gaaccgggcc ucugagcaug     1380

acaacccaac agucuaacuc ccagagcuuc ucuacauccc acgagggacu ggaagaggau     1440

aaagaccauc ccaccacgag cacacucacc ucuagcaauc gcaacgaugu gaccggcggg     1500

cggagagacc cuaaucacuc cgagggaagc acaacccugc uugaaggcua cacaucucac     1560

uauccccaua cgaaggaguc ccgcaccuuu auuccgguga caagcgcuaa aaccggcucc     1620

uucgggguca cagccguuac cgugggagau ucuaacagca augugaaccg gucccugucu     1680

ggcgaccaag auacguuuca cccuagcggg ggaucccaua ccacacacgg cucugaaagc     1740

gacgggcauu cccacggcag ccaggaggga ggcgccaaua ccacaucugg gcccaucaga     1800

acaccccaga uuccugagug gcucaucauu cuggcuuccc uucuggcccu cgcgcugauc     1860

cuggcugucu guaucgccgu gaacagccgc cggagaugcg gacagaagaa aaagcucguu     1920

auuaacucug gcaauggggc cguggaagau cgcaagccgu ccggacugaa cggcgaggcu     1980

agcaaaucuc aagaaauggu ccaccuugug aauaaggagu ccagcgaaac ccccgaccag     2040

uucaugaccg ccgacgagac gcggaaccug cagaauguug auaugaaaau cgggguguga     2100


<210>  881
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD4__Homo_sapiens__P01730

<400>  881

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  882
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD4__Homo_sapiens__AAA35572

<400>  882
augaaccggg gagucccuuu uaggcacuug cuucuggugc ugcaacuggc gcuccuccca       60

gcagccacuc agggaaagaa aguggugcug ggcaaaaaag gggauacagu ggaacugacc      120

uguacagcuu cccagaagaa gagcauacaa uuccacugga aaaacuccaa ccagauaaag      180

auucugggaa aucagggcuc cuucuuaacu aaagguccau ccaagcugaa ugaucgcgcu      240

gacucaagaa gaagccuuug ggaccaagga aacuuccccc ugaucaucaa gaaucuuaag      300

auagaagacu cagauacuua caucugugaa guggaggacc agaaggagga ggugcaauug      360

cuaguguucg gauugacugc caacucugac acccaccugc uucaggggca gagccugacc      420

cugaccuugg agagcccccc ugguaguagc cccucagugc aauguaggag uccaaggggu      480

aaaaacauac agggggggaa gacccucucc gugucucagc uggagcucca ggauaguggc      540

accuggacau gcacugucuu gcagaaccag aagaaggugg aguucaaaau agacaucgug      600

gugcuagcuu uccagaaggc cuccagcaua gucuauaaga aagaggggga acagguggag      660

uucuccuucc cacucgccuu uacaguugaa aagcugacgg gcaguggcga gcuguggugg      720

caggcggaga gggcuuccuc cuccaagucu uggaucaccu uugaccugaa gaacaaggaa      780

gugucuguaa aacggguuac ccaggacccu aagcuccaga ugggcaagaa gcucccgcuc      840

caccucaccc ugccccaggc cuugccucag uaugcuggcu cuggaaaccu cacccuggcc      900

cuugaagcga aaacaggaaa guugcaucag gaagugaacc ugguggugau gagagccacu      960

cagcuccaga aaaauuugac cugugaggug uggggaccca ccuccccuaa gcugaugcug     1020

agcuugaaac uggagaacaa ggaggcaaag gucucgaagc gggagaaggc ggugugggug     1080

cugaacccug aggcggggau guggcagugu cugcugagug acucgggaca gguccugcug     1140

gaauccaaca ucaagguucu gcccacaugg uccaccccgg ugcagccaau ggcccugauu     1200

gugcuggggg gcgucgccgg ccuccugcuu uucauugggc uaggcaucuu cuucuguguc     1260

aggugccggc accgaaggcg ccaagcagag cggaugucuc agaucaagag acuccucagu     1320

gagaagaaga ccugccagug cccucaccgg uuucagaaga cauguagccc cauuuga        1377


<210>  883
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD4__Homo_sapiens__AAA35572

<400>  883
augaaccgcg gcgugcccuu ccggcaccuc cuccuggucc ugcagcucgc ccugcugccg       60

gccgcgaccc aggggaagaa gguggugcuc ggcaagaagg gggacaccgu cgagcugacg      120

ugcaccgcca gccagaagaa guccauccag uuccacugga agaacagcaa ccagaucaag      180

auccugggca accagggguc cuuccucacc aagggcccca gcaagcugaa cgaccgcgcc      240

gacucccggc gcagccugug ggaccagggc aacuuccccc ucaucaucaa gaaccugaag      300

aucgaggacu ccgacaccua caucugcgag guggaggacc agaaggagga ggugcagcug      360

cucgucuucg ggcugacggc caacagcgac acccaccucc ugcagggcca gucccugacc      420

cugacccucg agagcccgcc cggguccagc cccuccgugc agugccggag cccccgcggc      480

aagaacaucc agggcgggaa gacgcugucc gugagccagc uggagcucca ggacuccggc      540

accuggaccu gcaccguccu gcagaaccag aagaaggugg aguucaagau cgacaucgug      600

guccuggccu uccagaaggc gagcuccauc guguacaaga aggaggggga gcaggucgag      660

uucagcuucc cccucgccuu cacgguggag aagcugaccg gcagcgggga gcuguggugg      720

caggccgagc gggccuccag cuccaagagc uggaucaccu ucgaccucaa gaacaaggag      780

guguccguga agcgcgucac ccaggacccg aagcugcaga ugggcaagaa gcugccccuc      840

caccugacgc ugccccaggc gcucccccag uacgccggca gcgggaaccu gacccuggcc      900

cucgaggcca agaccggcaa gcugcaccag gaggugaacc ugguggucau gcgggccacc      960

cagcuccaga agaaccugac gugcgaggug ugggggccga ccucccccaa gcugaugcuc     1020

agccugaagc uggagaacaa ggaggcgaag guguccaagc gcgagaaggc cgucugggug     1080

cucaaccccg aggccggcau guggcagugc cugcugagcg acuccgggca gguccugcuc     1140

gagagcaaca ucaaggugcu gcccaccugg uccaccccgg ugcagcccau ggcccugauc     1200

guccucggcg gcguggccgg gcugcugcug uucaucggcc uggggaucuu cuucugcgug     1260

cggugccgcc accggcgccg gcaggcggag cgcaugagcc agaucaagcg gcugcucucc     1320

gagaagaaga cgugccagug cccccaccgc uuccagaaga ccugcagccc caucuga        1377


<210>  884
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD4__Homo_sapiens__AAA35572

<400>  884
augaaccgcg gcguccccuu ccgccaccuc cuccucgucc uccagcucgc ccuccucccc       60

gccgccaccc agggcaagaa ggucguccuc ggcaagaagg gcgacaccgu cgagcucacc      120

ugcaccgccu cccagaagaa guccauccag uuccacugga agaacuccaa ccagaucaag      180

auccucggca accagggcuc cuuccucacc aagggccccu ccaagcucaa cgaccgcgcc      240

gacucccgcc gcucccucug ggaccagggc aacuuccccc ucaucaucaa gaaccucaag      300

aucgaggacu ccgacaccua caucugcgag gucgaggacc agaaggagga gguccagcuc      360

cucgucuucg gccucaccgc caacuccgac acccaccucc uccagggcca gucccucacc      420

cucacccucg aguccccccc cggcuccucc cccuccgucc agugccgcuc cccccgcggc      480

aagaacaucc agggcggcaa gacccucucc gucucccagc ucgagcucca ggacuccggc      540

accuggaccu gcaccguccu ccagaaccag aagaaggucg aguucaagau cgacaucguc      600

guccucgccu uccagaaggc cuccuccauc gucuacaaga aggagggcga gcaggucgag      660

uucuccuucc cccucgccuu caccgucgag aagcucaccg gcuccggcga gcucuggugg      720

caggccgagc gcgccuccuc cuccaagucc uggaucaccu ucgaccucaa gaacaaggag      780

gucuccguca agcgcgucac ccaggacccc aagcuccaga ugggcaagaa gcucccccuc      840

caccucaccc ucccccaggc ccucccccag uacgccggcu ccggcaaccu cacccucgcc      900

cucgaggcca agaccggcaa gcuccaccag gaggucaacc ucgucgucau gcgcgccacc      960

cagcuccaga agaaccucac cugcgagguc uggggcccca ccucccccaa gcucaugcuc     1020

ucccucaagc ucgagaacaa ggaggccaag gucuccaagc gcgagaaggc cgucuggguc     1080

cucaaccccg aggccggcau guggcagugc cuccucuccg acuccggcca gguccuccuc     1140

gaguccaaca ucaagguccu ccccaccugg uccacccccg uccagcccau ggcccucauc     1200

guccucggcg gcgucgccgg ccuccuccuc uucaucggcc ucggcaucuu cuucugcguc     1260

cgcugccgcc accgccgccg ccaggccgag cgcauguccc agaucaagcg ccuccucucc     1320

gagaagaaga ccugccagug cccccaccgc uuccagaaga ccugcucccc caucuga        1377


<210>  885
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD4__Homo_sapiens__AAA35572

<400>  885
augaacagag gcgugcccuu caggcaucug cuccuugucc ugcaguuggc cuuacugccu       60

gcugcaaccc aagggaagaa aguugugcua ggaaagaaag gugacacagu agagcucacu      120

ugcacggcca gccagaagaa auccauccag uuucacugga aaaauucuaa ccagauuaag      180

auacugggca aucaaggguc auuccuuacc aaaggaccaa guaagcugaa cgaucgggcg      240

gacagccgcc gauccuugug ggaucagggc aauuuuccgc ucaucauuaa aaaccugaag      300

aucgaagacu cugauacaua cauuugugag guggaagacc agaaagagga aguccagcug      360

cucguguucg guuuaacugc uaauucggau acccaucugc uucaagggca gucauugaca      420

cugacccuag agaguccccc uggaagcucc ccaucuguuc agugccguag ccccagaggc      480

aagaacaucc agggcgggaa gacucucucc gugucacaac uggagcuuca ggacagugga      540

acauggaccu guacgguccu gcagaaucaa aagaaggugg aauuuaaaau agauaucgua      600

guuuuggccu uccagaaggc aagcucuauu guguauaaaa aggaggguga acaggucgag      660

uuuuccuucc cucucgccuu uacuguggag aaacugaccg gcucagggga auuauggugg      720

caggcugaga gggcaagcag uucuaagucc uggaucacau ucgaccugaa gaacaaagaa      780

gugagcguca agcggguuac ucaagaucca aaacuccaga ugggaaagaa acuuccccug      840

cacuugaccc uaccucaggc ccugccacag uacgcuggcu cggguaaucu cacacuggcc      900

cuugaggcga agaccgggaa gcugcaccaa gaagugaacu ugguagugau gcgcgcaacg      960

cagcuccaga aaaaucugac uugcgagguc uggggaccga caucucccaa guuaaugcug     1020

ucccuaaaac ucgagaacaa ggaagccaaa gugucaaaga gagagaaggc uguuugggug     1080

cugaauccug aagccggcau guggcagugu cuuuugagug acagcggcca aguccugcuc     1140

gaguccaaca uuaaagugcu gccaaccugg ucuacucccg uacagccuau ggcacuuauc     1200

guucugggag ggguggcugg uuugcuccug uuuauaggcu uagggauuuu cuuuugcguc     1260

aggugucggc aucgccgaag acaggccgaa aggaugagcc agaucaagcg gcugcuauca     1320

gagaaaaaga caugccaaug uccacaccgu uuccagaaaa ccugcagucc cauuuga        1377


<210>  886
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD4__Homo_sapiens__AAA35572

<400>  886
augaacagag gcgugcccuu cagacaccug cugcuggugc ugcagcuggc ccugcugccc       60

gccgccaccc agggcaagaa gguggugcug ggcaagaagg gcgacaccgu ggagcugacc      120

ugcaccgcca gccagaagaa gagcauccag uuccacugga agaacagcaa ccagaucaag      180

auccugggca accagggcag cuuccugacc aagggcccca gcaagcugaa cgacagagcc      240

gacagcagaa gaagccugug ggaccagggc aacuuccccc ugaucaucaa gaaccugaag      300

aucgaggaca gcgacaccua caucugcgag guggaggacc agaaggagga ggugcagcug      360

cugguguucg gccugaccgc caacagcgac acccaccugc ugcagggcca gagccugacc      420

cugacccugg agagcccccc cggcagcagc cccagcgugc agugcagaag ccccagaggc      480

aagaacaucc agggcggcaa gacccugagc gugagccagc uggagcugca ggacagcggc      540

accuggaccu gcaccgugcu gcagaaccag aagaaggugg aguucaagau cgacaucgug      600

gugcuggccu uccagaaggc cagcagcauc guguacaaga aggagggcga gcagguggag      660

uucagcuucc cccuggccuu caccguggag aagcugaccg gcagcggcga gcuguggugg      720

caggccgaga gagccagcag cagcaagagc uggaucaccu ucgaccugaa gaacaaggag      780

gugagcguga agagagugac ccaggacccc aagcugcaga ugggcaagaa gcugccccug      840

caccugaccc ugccccaggc ccugccccag uacgccggca gcggcaaccu gacccuggcc      900

cuggaggcca agaccggcaa gcugcaccag gaggugaacc ugguggugau gagagccacc      960

cagcugcaga agaaccugac cugcgaggug uggggcccca ccagccccaa gcugaugcug     1020

agccugaagc uggagaacaa ggaggccaag gugagcaaga gagagaaggc cgugugggug     1080

cugaaccccg aggccggcau guggcagugc cugcugagcg acagcggcca ggugcugcug     1140

gagagcaaca ucaaggugcu gcccaccugg agcacccccg ugcagcccau ggcccugauc     1200

gugcugggcg gcguggccgg ccugcugcug uucaucggcc ugggcaucuu cuucugcgug     1260

agaugcagac acagaagaag acaggccgag agaaugagcc agaucaagag acugcugagc     1320

gagaagaaga ccugccagug cccccacaga uuccagaaga ccugcagccc caucuga        1377


<210>  887
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD4__Homo_sapiens__AAA35572

<400>  887
augaacagag gcgugcccuu ccggcaucug cuccuggucc uucagcuggc ccuccugccu       60

gcugccaccc aagggaagaa aguugugcuu ggaaagaaag gcgacacagu ggagcugacg      120

ugcaccgcga gccagaagaa auccauccag uuucacugga aaaauucuaa ccagauuaag      180

auccucggga aucaaggcag cuuccugaca aaaggaccgu ccaagcugaa cgaucgcgcu      240

gacucuagac ggagccucug ggaucagggg aauuuucccc ugauuaucaa aaaccuuaag      300

auugaagacu ccgauaccua caucugugag gucgaagacc agaaagagga agugcagcug      360

cucguuuucg gacugacagc caauucugau acccaccuuc ugcaaggcca gagccucaca      420

cugacccugg aguccccucc cggcagcucu ccuuccgugc agugccgcag ccccagaggg      480

aagaacaucc agggaggcaa gacgcucucu gucucccaac uggagcuuca ggacagcggg      540

accuggacau guaccgugcu gcagaaucaa aagaagguug aauuuaaaau ugauaucgug      600

guccucgccu uccagaaggc uucuuccauu guguauaaaa aggagggaga acagguggag      660

uuuagcuucc cucuggccuu uacagucgag aaacuuaccg gcuccgggga acuguggugg      720

caggcugagc gggccucuag cuccaagagc uggaucacgu ucgaccucaa gaacaaagaa      780

guuucuguga agcgcgugac acaagauccg aaacugcaga ugggaaagaa acugccccuc      840

caucugaccc uuccucaggc gcugccccag uacgccggcu ccggcaaucu cacacuggcu      900

cuugaggcca agaccgggaa gcugcaccaa gaagucaacc ucgugguuau gagagcuacc      960

cagcugcaga aaaaucugac augcgaggug uggggaccua cgagccccaa gcucaugcug     1020

ucucuuaaac uggagaacaa ggaagccaaa gucagcaagc gggagaaggc gguguggguu     1080

cucaauccgg aagccggcau guggcagugu cugcuguccg acucugggca agugcuucuc     1140

gagagcaaca uuaaaguccu gccuaccugg uccacacccg ugcagccuau ggcucugauc     1200

guccucggag gcguggccgg gcugcuucug uuuauuggac ucggcaucuu cuuuugcguu     1260

cgcuguagac aucggcgcag acaggcugaa cggaugagcc agaucaagcg ccugcugucu     1320

gagaaaaaga ccugccaaug uccccacaga uuccagaaaa caugcucccc cauuuga        1377


<210>  888
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__P31358

<400>  888

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Asn Ile Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  889
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__CAA44323

<400>  889
augaagcgcu uccucuuccu ccuacucacc aucagccucc ugguuauggu acagauacaa       60

acuggacucu caggacaaaa cgacaccagc caaaccagca gccccucagc auccagcaac      120

auaagcggag gcauuuuccu uuucuucgug gccaaugcca uaauccaccu cuucugcuuc      180

aguuga                                                                 186


<210>  890
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD52__Homo_sapiens__CAA44323

<400>  890
augaagcgcu uccuguuccu ccugcugacc aucagccucc uggugauggu ccagauccag       60

accggccugu ccgggcagaa cgacacgagc cagaccucca gccccuccgc cagcuccaac      120

aucagcggcg ggaucuuccu cuucuucgug gccaacgcga ucauccaccu guucugcuuc      180

uccuga                                                                 186


<210>  891
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD52__Homo_sapiens__CAA44323

<400>  891
augaagcgcu uccucuuccu ccuccucacc aucucccucc ucgucauggu ccagauccag       60

accggccucu ccggccagaa cgacaccucc cagaccuccu cccccuccgc cuccuccaac      120

aucuccggcg gcaucuuccu cuucuucguc gccaacgcca ucauccaccu cuucugcuuc      180

uccuga                                                                 186


<210>  892
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD52__Homo_sapiens__CAA44323

<400>  892
augaagagau uccuguuucu ccuucugacc aucagcuugu uagugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacuucu cagacgucaa gucccagcgc cuccucuaau      120

auaucgggag guaucuuccu auuuuucguu gcuaacgcaa uuauccaccu cuuuugcuuc      180

ucauga                                                                 186


<210>  893
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD52__Homo_sapiens__CAA44323

<400>  893
augaagagau uccuguuccu gcugcugacc aucagccugc uggugauggu gcagauccag       60

accggccuga gcggccagaa cgacaccagc cagaccagca gccccagcgc cagcagcaac      120

aucagcggcg gcaucuuccu guucuucgug gccaacgcca ucauccaccu guucugcuuc      180

agcuga                                                                 186


<210>  894
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD52__Homo_sapiens__CAA44323

<400>  894
augaagagau uccuguuucu ccugcuuacc aucagccugc ucgugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacgucu cagaccagcu cccccucugc cagcuccaau      120

aucucuggag gcauuuuccu uuucuuuguu gcuaacgcca ucauucaccu guuuugcuuc      180

agcuga                                                                 186


<210>  895
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__Q6IBD0

<400>  895

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Ser Met Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  896
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__AAP35780

<400>  896
augaagcgcu uccucuuccu ccuacucacc aucagccucc ugguuauggu acagauacaa       60

acuggacucu caggacaaaa cgacaccagc caaaccagca gccccucagc auccagcagc      120

augagcggag gcauuuuccu uuucuucgug gccaaugcca uaauccaccu cuucugcuuc      180

aguuag                                                                 186


<210>  897
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD52__Homo_sapiens__AAP35780

<400>  897
augaagcgcu uccuguuccu ccugcugacc aucagccucc uggugauggu ccagauccag       60

accggccugu ccgggcagaa cgacacgagc cagaccucca gccccuccgc cagcuccagc      120

auguccggcg ggaucuuccu cuucuucgug gccaacgcga ucauccaccu guucugcuuc      180

agcuga                                                                 186


<210>  898
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD52__Homo_sapiens__AAP35780

<400>  898
augaagcgcu uccucuuccu ccuccucacc aucucccucc ucgucauggu ccagauccag       60

accggccucu ccggccagaa cgacaccucc cagaccuccu cccccuccgc cuccuccucc      120

auguccggcg gcaucuuccu cuucuucguc gccaacgcca ucauccaccu cuucugcuuc      180

uccuga                                                                 186


<210>  899
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD52__Homo_sapiens__AAP35780

<400>  899
augaagagau uccuguuucu ccuucugacc aucagcuugu uagugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacuucu cagacgucaa gucccagcgc cuccucuucg      120

augucaggag guauauuccu auuuuucguu gcuaaugcaa ucauucaccu cuuuugcuuc      180

agcuga                                                                 186


<210>  900
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD52__Homo_sapiens__AAP35780

<400>  900
augaagagau uccuguuccu gcugcugacc aucagccugc uggugauggu gcagauccag       60

accggccuga gcggccagaa cgacaccagc cagaccagca gccccagcgc cagcagcagc      120

augagcggcg gcaucuuccu guucuucgug gccaacgcca ucauccaccu guucugcuuc      180

agcuga                                                                 186


<210>  901
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD52__Homo_sapiens__AAP35780

<400>  901
augaagagau uccuguuucu ccugcuuacc aucagccugc ucgugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacgucu cagaccagcu cccccucugc cagcuccucu      120

augagcggag gcaucuuccu uuucuuuguu gcuaaugcca uuauccaccu guuuugcuuc      180

uccuga                                                                 186


<210>  902
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__V9HWN9

<400>  902

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Asn Ile Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  903
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD52__Homo_sapiens__ACS44650

<400>  903
augaagcgcu uccucuuccu ccuacucacc aucagccucc ugguuauggu acagauacaa       60

acuggacucu caggacaaaa cgacaccagc caaaccagca gccccucagc auccagcaac      120

auaagcggag gcauuuuccu uuucuucgug gccaaugcca uaauccaccu cuucugcuuc      180

aguuga                                                                 186


<210>  904
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD52__Homo_sapiens__ACS44650

<400>  904
augaagcgcu uccuguuccu ccugcugacc aucagccucc uggugauggu ccagauccag       60

accggccugu ccgggcagaa cgacacgagc cagaccucca gccccuccgc cagcuccaac      120

aucagcggcg ggaucuuccu cuucuucgug gccaacgcga ucauccaccu guucugcuuc      180

uccuga                                                                 186


<210>  905
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD52__Homo_sapiens__ACS44650

<400>  905
augaagcgcu uccucuuccu ccuccucacc aucucccucc ucgucauggu ccagauccag       60

accggccucu ccggccagaa cgacaccucc cagaccuccu cccccuccgc cuccuccaac      120

aucuccggcg gcaucuuccu cuucuucguc gccaacgcca ucauccaccu cuucugcuuc      180

uccuga                                                                 186


<210>  906
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD52__Homo_sapiens__ACS44650

<400>  906
augaagagau uccuguuucu ccuucugacc aucagcuugu uagugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacuucu cagacgucaa gucccagcgc cuccucuaau      120

auaucgggag guaucuuccu auuuuucguu gcuaacgcaa uuauccaccu cuuuugcuuc      180

ucauga                                                                 186


<210>  907
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD52__Homo_sapiens__ACS44650

<400>  907
augaagagau uccuguuccu gcugcugacc aucagccugc uggugauggu gcagauccag       60

accggccuga gcggccagaa cgacaccagc cagaccagca gccccagcgc cagcagcaac      120

aucagcggcg gcaucuuccu guucuucgug gccaacgcca ucauccaccu guucugcuuc      180

agcuga                                                                 186


<210>  908
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD52__Homo_sapiens__ACS44650

<400>  908
augaagagau uccuguuucu ccugcuuacc aucagccugc ucgugauggu ccagauucaa       60

acaggccugu ccgggcagaa cgacacgucu cagaccagcu cccccucugc cagcuccaau      120

aucucuggag gcauuuuccu uuucuuuguu gcuaacgcca ucauucaccu guuuugcuuc      180

agcuga                                                                 186


<210>  909
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__B1AP15

<400>  909

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Gln 
                85                  90                  95      


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
            100                 105                 110         


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
        115                 120                 125             


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
    130                 135                 140                 


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
                165                 170                 175     


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
            180                 185                 190         


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
        195                 200                 205             


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
    210                 215                 220                 


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
225                 230                 235                 240 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
                245                 250                 255     


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
            260                 265                 270         


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
        275                 280                 285             


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
    290                 295                 300                 


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
305                 310                 315         


<210>  910
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__EAW93489

<400>  910
augaccgucg cgcggccgag cgugcccgcg gcgcugcccc uccucgggga gcugccccgg       60

cugcugcugc uggugcuguu gugccugccg gccguguggg gugacugugg ccuuccccca      120

gauguaccua augcccagcc agcuuuggaa ggccguacaa guuuucccga ggauacugua      180

auaacguaca aaugugaaga aagcuuugug aaaauuccug gcgagaagga cucagugauc      240

ugccuuaagg gcagucaaug gucagauauu gaagaguucu gcaaucagaa aucaugcccu      300

aauccgggag aaauacgaaa uggucagauu gauguaccag guggcauauu auuuggugca      360

accaucuccu ucucauguaa cacaggguac aaauuauuug gcucgacuuc uaguuuuugu      420

cuuauuucag gcagcucugu ccaguggagu gacccguugc cagagugcag agaaauuuau      480

uguccagcac caccacaaau ugacaaugga auaauucaag gggaacguga ccauuaugga      540

uauagacagu cuguaacgua ugcauguaau aaaggauuca ccaugauugg agagcacucu      600

auuuauugua cugugaauaa ugaugaagga gaguggagug gcccaccacc ugaaugcaga      660

ggaaaaucuc uaacuuccaa ggucccacca acaguucaga aaccuaccac aguaaauguu      720

ccaacuacag aagucucacc aacuucucag aaaaccacca caaaaaccac cacaccaaau      780

gcucaagcaa cacggaguac accuguuucc aggacaacca agcauuuuca ugaaacaacc      840

ccaaauaaag gaaguggaac cacuucaggu acuacccguc uucuaucugg gcacacgugu      900

uucacguuga cagguuugcu ugggacgcua guaaccaugg gcuugcugac uuag            954


<210>  911
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD55__Homo_sapiens__EAW93489

<400>  911
augaccgugg cccgccccag cgucccggcc gcgcugcccc uccugggcga gcugccccgg       60

cuccugcugc ucgugcugcu gugccucccc gccguguggg gcgacugcgg gcugccgccc      120

gacgucccca acgcccagcc cgcccuggag gggcgcaccu ccuucccgga ggacacggug      180

aucaccuaca agugcgagga gagcuucgug aagauccccg gcgagaagga cuccgucauc      240

ugccucaagg ggagccagug guccgacauc gaggaguucu gcaaccagaa guccugcccc      300

aaccccggcg agauccggaa cggccagauc gacgugcccg ggggcauccu guucggggcc      360

accaucagcu ucagcugcaa caccggcuac aagcuguucg gguccacgag cuccuucugc      420

cucaucagcg gcuccagcgu gcaguggucc gacccccugc ccgagugccg cgagaucuac      480

ugccccgcgc cgccccagau cgacaacggc aucauccagg gggagcggga ccacuacggc      540

uaccgccaga gcgucaccua cgccugcaac aagggguuca ccaugaucgg cgagcacucc      600

aucuacugca ccgugaacaa cgacgagggc gaguggagcg ggccgccccc ggagugccgg      660

ggcaaguccc ugacgagcaa ggugccgccc accguccaga agcccaccac cgugaacgug      720

cccacgaccg aggucagccc caccucccag aagaccacga ccaagaccac cacgcccaac      780

gcccaggcca cccgcagcac ccccgugucc cggaccacga agcacuucca cgagaccacc      840

ccgaacaagg ggagcggcac cacguccggg accacccgcc uccugagcgg ccacacgugc      900

uucacccuga ccggccuccu ggggacccug gugaccaugg gccuccugac guga            954


<210>  912
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD55__Homo_sapiens__EAW93489

<400>  912
augaccgucg cccgccccuc cguccccgcc gcccuccccc uccucggcga gcucccccgc       60

cuccuccucc ucguccuccu cugccucccc gccgucuggg gcgacugcgg ccuccccccc      120

gacgucccca acgcccagcc cgcccucgag ggccgcaccu ccuuccccga ggacaccguc      180

aucaccuaca agugcgagga guccuucguc aagauccccg gcgagaagga cuccgucauc      240

ugccucaagg gcucccagug guccgacauc gaggaguucu gcaaccagaa guccugcccc      300

aaccccggcg agauccgcaa cggccagauc gacguccccg gcggcauccu cuucggcgcc      360

accaucuccu ucuccugcaa caccggcuac aagcucuucg gcuccaccuc cuccuucugc      420

cucaucuccg gcuccuccgu ccaguggucc gacccccucc ccgagugccg cgagaucuac      480

ugccccgccc ccccccagau cgacaacggc aucauccagg gcgagcgcga ccacuacggc      540

uaccgccagu ccgucaccua cgccugcaac aagggcuuca ccaugaucgg cgagcacucc      600

aucuacugca ccgucaacaa cgacgagggc gagugguccg gccccccccc cgagugccgc      660

ggcaaguccc ucaccuccaa gguccccccc accguccaga agcccaccac cgucaacguc      720

cccaccaccg aggucucccc caccucccag aagaccacca ccaagaccac cacccccaac      780

gcccaggcca cccgcuccac ccccgucucc cgcaccacca agcacuucca cgagaccacc      840

cccaacaagg gcuccggcac caccuccggc accacccgcc uccucuccgg ccacaccugc      900

uucacccuca ccggccuccu cggcacccuc gucaccaugg gccuccucac cuga            954


<210>  913
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD55__Homo_sapiens__EAW93489

<400>  913
augaccgugg ccagacccag cgucccugcu gcacugccac uccuuggcga gcugccgagg       60

uuguuacugc uaguucuccu gugccuuccc gccguguggg gagacugugg gcugccucca      120

gauguaccca acgcgcagcc ugcuuuggaa ggucggacau ccuucccaga ggacacugug      180

aucacguaca agugcgaaga gucuuuuguc aaaauucccg gcgaaaagga uucagugaua      240

ugucucaaag ggagucaaug gagcgacauc gaggaguucu gcaaucagaa guccuguccu      300

aacccaggag aaauucgcaa uggccagauc gauguuccgg gugggauucu guuuggagcc      360

accaucucuu ucucgugcaa cacaggcuau aaacuguuug gcucaacuag caguuucugu      420

cucauauccg ggucuagcgu gcaguggucc gaccccuuac cugagugccg agaaaucuac      480

uguccagcac ccccucaaau ugauaaugga aucauucagg gugagcguga ccacuauggc      540

uacagacagu cagucaccua ugccugcaac aagggguuua caaugaucgg agagcauagu      600

auauacugua ccgugaauaa cgaugaaggc gaguggagcg guccaccccc ggaaugcagg      660

gggaagucuc ugacuuccaa aguaccuccc acaguucaga agccaaccac ggugaauguc      720

ccuacuaccg aggugucacc cacaagccag aaaacuacca caaagaccac gacuccaaac      780

gcucaagcaa cacggaguac ccccgugucu cgcacuacaa aacacuucca ugaaaccacg      840

ccuaauaagg gauccggcac cacaagcggc acuaccagac uuuugucggg gcacacaugc      900

uuuacucuga ccggacuacu cgguacacug gucaccaugg gccuucugac uuga            954


<210>  914
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD55__Homo_sapiens__EAW93489

<400>  914
augaccgugg ccagacccag cgugcccgcc gcccugcccc ugcugggcga gcugcccaga       60

cugcugcugc uggugcugcu gugccugccc gccguguggg gcgacugcgg ccugcccccc      120

gacgugccca acgcccagcc cgcccuggag ggcagaacca gcuuccccga ggacaccgug      180

aucaccuaca agugcgagga gagcuucgug aagauccccg gcgagaagga cagcgugauc      240

ugccugaagg gcagccagug gagcgacauc gaggaguucu gcaaccagaa gagcugcccc      300

aaccccggcg agaucagaaa cggccagauc gacgugcccg gcggcauccu guucggcgcc      360

accaucagcu ucagcugcaa caccggcuac aagcuguucg gcagcaccag cagcuucugc      420

cugaucagcg gcagcagcgu gcaguggagc gacccccugc ccgagugcag agagaucuac      480

ugccccgccc ccccccagau cgacaacggc aucauccagg gcgagagaga ccacuacggc      540

uacagacaga gcgugaccua cgccugcaac aagggcuuca ccaugaucgg cgagcacagc      600

aucuacugca ccgugaacaa cgacgagggc gaguggagcg gccccccccc cgagugcaga      660

ggcaagagcc ugaccagcaa ggugcccccc accgugcaga agcccaccac cgugaacgug      720

cccaccaccg aggugagccc caccagccag aagaccacca ccaagaccac cacccccaac      780

gcccaggcca ccagaagcac ccccgugagc agaaccacca agcacuucca cgagaccacc      840

cccaacaagg gcagcggcac caccagcggc accaccagac ugcugagcgg ccacaccugc      900

uucacccuga ccggccugcu gggcacccug gugaccaugg gccugcugac cuga            954


<210>  915
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD55__Homo_sapiens__EAW93489

<400>  915
augaccgugg ccagacccag cgucccugcu gcccugccgc uccugggcga gcuuccccgg       60

cugcuccugc uuguucugcu cugccugccu gcgguguggg gcgacugugg acugcccccu      120

gaugugccca acgcucagcc ugcccucgaa ggccgcacau ccuucccgga ggacacgguc      180

aucaccuaca agugcgaaga gucuuuugug aaaauucccg gggaaaagga uagcguuauc      240

ugucugaaag gaucccaaug gucugacauu gaggaguucu gcaaucaaaa gagcuguccu      300

aaccccggcg aaaucagaaa ugggcagauu gaugugccug gaggcauccu uuuuggcgcc      360

acaaucuccu ucucuugcaa caccggguau aaacuguuug gaagcacauc cagcuucugu      420

cucauuucug gcuccagcgu ccaguggucu gacccccugc cggagugccg ggaaaucuac      480

uguccugcuc ccccucaaau ugauaauggg aucauucagg gagagcgcga ccacuauggc      540

uacagacagu ccgugaccua ugccugcaac aagggguuua caaugaucgg agagcauagc      600

auuuacugua ccguuaauaa cgaugaaggc gaguggucug ggcccccucc cgaaugccgg      660

gggaaguccc uuacgagcaa agugccgccc accguccaga agccuacaac cgugaaugug      720

cccacaaccg aggucucccc uacgucucag aaaacaacca caaagaccac cacacccaac      780

gcucaggcca cgcgcagcac cccgguuucc agaacaacca aacacuucca ugaaacaacc      840

ccuaauaagg gaagcggcac gacaucuggg accacccggc ugcucuccgg acacacaugc      900

uuuacccuga caggccugcu cgggacgcug gugaccaugg gacuucugac auga            954


<210>  916
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__D3DT85

<400>  916

Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
1               5                   10                  15      


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser 
            20                  25                  30          


Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr 
        35                  40                  45              


Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr 
    50                  55                  60                  


Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys His Thr 
65                  70                  75                  80  


Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln Lys Pro 
                85                  90                  95      


Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro Gln Lys 
            100                 105                 110         


Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr Pro Gln 
        115                 120                 125             


Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro Thr Leu 
    130                 135                 140                 


Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr Pro Ser 
                165                 170                 175     


Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln Ala Thr 
            180                 185                 190         


Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr Gln Ser 
        195                 200                 205             


Pro Ser Ala Ala Arg Lys Ser Thr Asn Val His Ser Pro Val Thr Asn 
    210                 215                 220                 


Gly Leu Lys Ser Thr Gln Arg Phe Pro Ser Ala His Ile Thr Ala Thr 
225                 230                 235                 240 


Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr 
                245                 250                 255     


Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser 
            260                 265                 270         


Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr 
        275                 280                 285             


Met Gly Leu Leu Thr 
    290             


<210>  917
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__EAW93497

<400>  917
augauuggag agcacucuau uuauuguacu gugaauaaug augaaggaga guggaguggc       60

ccaccaccug aaugcagagg aaaaucucua acuuccaagg ucccaccaac aguucagaaa      120

ccuaccacag uaaauguucc aacuacagaa gucucaccaa cuucucagaa aaccaccaca      180

aaaaccacca caccaaaugc ucaagguaca gagacuccau caguucuuca aaaacacacc      240

acagaaaaug uuucagcuac aagaacccca ccaacuccuc agaaacccac cacaguaaau      300

gucccagcua caauagucac accaacaccu cagaaaccca ccacaauaaa uguuccagcu      360

acaggagucu caucaacacc ucaaagacac accauaguaa auguuucagc uacaggaacc      420

cuaccaacuc uucagaaacc caccagagca aaugauucag ccaccaaauc cccagcagca      480

gcucagacau cuuucauauc aaaaacccua ucuacaaaga ccccuucugc agcucagaau      540

cccaugauga caaaugcuuc ugcuacacag gccacacuaa cagcccaaaa auucaccaca      600

gcaaaaguug cauuuacgca gaguccuuca gcagcacgua aguccacuaa uguacauucc      660

ccagugacua auggucucaa gaguacacaa agauucccuu cugcucauau uacagcaaca      720

cggaguacac cuguuuccag gacaaccaag cauuuucaug aaacaacccc aaauaaagga      780

aguggaacca cuucagguac uacccgucuu cuaucugggc acacguguuu cacguugaca      840

gguuugcuug ggacgcuagu aaccaugggc uugcugacuu ag                         882


<210>  918
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD55__Homo_sapiens__EAW93497

<400>  918
augaucggcg agcacagcau cuacugcacc gugaacaacg acgaggggga gugguccggg       60

cccccgcccg agugccgcgg caagagccug accuccaagg ucccgcccac ggugcagaag      120

cccaccaccg ugaacguccc caccacggag gugagcccca ccucccagaa gaccaccacg      180

aagaccacca cccccaacgc ccagggcacg gagaccccga gcgugcucca gaagcacacc      240

accgagaacg ucuccgccac gcggaccccg cccacgcccc agaagcccac caccgugaac      300

gugcccgcga ccaucgucac ccccacgccc cagaagccga ccaccaucaa cgugcccgcc      360

accgggguga gcuccacgcc ccagcgccac accaucguca acgugagcgc caccggcacc      420

cugcccaccc ugcagaagcc gacgcgggcc aacgacuccg ccaccaagag ccccgcggcc      480

gcccagaccu ccuucaucag caagacccuc uccacgaaga cccccagcgc cgcgcagaac      540

cccaugauga ccaacgccuc cgccacccag gccacccuga cggcccagaa guucaccacc      600

gcgaaggugg ccuucaccca gagcccgucc gccgcccgca agagcacgaa cguccacagc      660

cccgugacca acggccugaa guccacccag cgguucccca gcgcccacau caccgcgacg      720

cgcuccaccc ccgugagccg gaccaccaag cacuuccacg agacgacccc gaacaagggg      780

uccggcacca ccagcgggac gacccgccuc cuguccggcc acacgugcuu cacccugacc      840

gggcuccugg gcacccuggu caccaugggc cuccugaccu ga                         882


<210>  919
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD55__Homo_sapiens__EAW93497

<400>  919
augaucggcg agcacuccau cuacugcacc gucaacaacg acgagggcga gugguccggc       60

cccccccccg agugccgcgg caagucccuc accuccaagg ucccccccac cguccagaag      120

cccaccaccg ucaacguccc caccaccgag gucuccccca ccucccagaa gaccaccacc      180

aagaccacca cccccaacgc ccagggcacc gagacccccu ccguccucca gaagcacacc      240

accgagaacg ucuccgccac ccgcaccccc cccacccccc agaagcccac caccgucaac      300

guccccgcca ccaucgucac ccccaccccc cagaagccca ccaccaucaa cguccccgcc      360

accggcgucu ccuccacccc ccagcgccac accaucguca acgucuccgc caccggcacc      420

cuccccaccc uccagaagcc cacccgcgcc aacgacuccg ccaccaaguc ccccgccgcc      480

gcccagaccu ccuucaucuc caagacccuc uccaccaaga cccccuccgc cgcccagaac      540

cccaugauga ccaacgccuc cgccacccag gccacccuca ccgcccagaa guucaccacc      600

gccaaggucg ccuucaccca gucccccucc gccgcccgca aguccaccaa cguccacucc      660

cccgucacca acggccucaa guccacccag cgcuuccccu ccgcccacau caccgccacc      720

cgcuccaccc ccgucucccg caccaccaag cacuuccacg agaccacccc caacaagggc      780

uccggcacca ccuccggcac cacccgccuc cucuccggcc acaccugcuu cacccucacc      840

ggccuccucg gcacccucgu caccaugggc cuccucaccu ga                         882


<210>  920
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD55__Homo_sapiens__EAW93497

<400>  920
augaucggcg agcacagcau uuacugcacc gugaacaaug acgaagggga gugguccgga       60

cccccuccag aauguagagg uaagucucug acaucaaaag ucccgcccac uguucagaag      120

ccuacgaccg ugaacguacc aacaacugag gugaguccca ccagccagaa aacaaccacu      180

aagacaacca cgccuaaugc ccaaggcacu gaaaccccau ccguccucca gaaacauaca      240

acugagaacg ugucugcuac caggacaccc ccuaccccac agaagccgac gacuguuaau      300

gugcccgcaa caauagucac cccuacucca caaaagccca caaccaucaa cgugccugcc      360

acggggguau cgucaacccc acagcggcac acaauuguua augugagcgc gacuggaacc      420

cuucccacac ugcagaaacc gacucgcgcu aacgauagug ccaccaaguc cccugcagcc      480

gcucagacau cuuucaucag caaaaccuug uccacuaaga cgcccucagc agcccaaaau      540

ccaaugauga caaacgcuag ugccacccag gcgacuuuaa ccgcacagaa auuuacaacc      600

gccaaggucg cuuucacuca gagcccuucu gccgcacgaa aguccacaaa ugugcauuca      660

cccgugacga acggccugaa aagcacccaa cguuuuccaa gugcucacau uacugccaca      720

agaucuaccc ccgucuccag gacaacuaag cauuuccacg agaccacgcc uaauaaaggu      780

agcgggacca caucgggaac uacccggcua cucucuggcc acacaugcuu uacucugacc      840

ggccuucugg ggacguuggu uacaauggga cuccugaccu ga                         882


<210>  921
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD55__Homo_sapiens__EAW93497

<400>  921
augaucggcg agcacagcau cuacugcacc gugaacaacg acgagggcga guggagcggc       60

cccccccccg agugcagagg caagagccug accagcaagg ugccccccac cgugcagaag      120

cccaccaccg ugaacgugcc caccaccgag gugagcccca ccagccagaa gaccaccacc      180

aagaccacca cccccaacgc ccagggcacc gagaccccca gcgugcugca gaagcacacc      240

accgagaacg ugagcgccac cagaaccccc cccacccccc agaagcccac caccgugaac      300

gugcccgcca ccaucgugac ccccaccccc cagaagccca ccaccaucaa cgugcccgcc      360

accggcguga gcagcacccc ccagagacac accaucguga acgugagcgc caccggcacc      420

cugcccaccc ugcagaagcc caccagagcc aacgacagcg ccaccaagag ccccgccgcc      480

gcccagacca gcuucaucag caagacccug agcaccaaga cccccagcgc cgcccagaac      540

cccaugauga ccaacgccag cgccacccag gccacccuga ccgcccagaa guucaccacc      600

gccaaggugg ccuucaccca gagccccagc gccgccagaa agagcaccaa cgugcacagc      660

cccgugacca acggccugaa gagcacccag agauucccca gcgcccacau caccgccacc      720

agaagcaccc ccgugagcag aaccaccaag cacuuccacg agaccacccc caacaagggc      780

agcggcacca ccagcggcac caccagacug cugagcggcc acaccugcuu cacccugacc      840

ggccugcugg gcacccuggu gaccaugggc cugcugaccu ga                         882


<210>  922
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD55__Homo_sapiens__EAW93497

<400>  922
augaucggcg agcacagcau uuacugcacc gugaacaaug acgaagggga gugguccgga       60

cccccuccgg aauguagagg caagucucug acaagcaaag uucccccuac gguccagaag      120

cccaccacag ugaacgugcc uaccacagag gucuccccca ccucucaaaa gacaaccacg      180

aagaccacaa ccccuaaugc ccaggggaca gaaaccccga gcgugcucca gaaacauacg      240

acagagaacg uuuccgcuac ccggacaccc ccuacacccc agaagccuac caccgugaau      300

guccccgcca cgaucgugac cccgacaccu caaaagccca ccacaauuaa cguuccugcg      360

accggagugu cuagcacgcc ccagcgccac acaaucguca auguguccgc uaccggcacc      420

cugcccacac uucagaaacc uaccagagcc aacgauagcg ccacaaaguc uccggcugcc      480

gcucagacgu ccuucauuag caaaacccug ucuacaaaga cccccuccgc cgcgcaaaau      540

ccuaugauga caaacgccag cgcuacccag gccacgcuca ccgcucagaa auuuacaacc      600

gccaaggugg cguucacaca gucucccucc gccgcucgga aaagcaccaa uguccauucc      660

ccuguuacga acgggcugaa aucuacacaa cgcuuuccca gcgcccacau caccgcuaca      720

agauccaccc cggugagccg gaccacaaag cauuuccacg agacgacccc uaauaaagga      780

ucuggcacaa ccuccggcac aacccgccuu cugagcgggc acacgugcuu uacacucacc      840

ggacugcugg gcacccucgu gacaaugggg cugcuuaccu ga                         882


<210>  923
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__D3DT86

<400>  923

Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
1               5                   10                  15      


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser 
            20                  25                  30          


Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr 
        35                  40                  45              


Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr 
    50                  55                  60                  


Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys His Thr 
65                  70                  75                  80  


Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln Lys Pro 
                85                  90                  95      


Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro Gln Lys 
            100                 105                 110         


Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr Pro Gln 
        115                 120                 125             


Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro Thr Leu 
    130                 135                 140                 


Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr Pro Ser 
                165                 170                 175     


Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln Ala Thr 
            180                 185                 190         


Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr Gln Ser 
        195                 200                 205             


Pro Ser Ala Ala Pro Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys 
    210                 215                 220                 


His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly 
225                 230                 235                 240 


Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu 
                245                 250                 255     


Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            260                 265         


<210>  924
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__EAW93493

<400>  924
augauuggag agcacucuau uuauuguacu gugaauaaug augaaggaga guggaguggc       60

ccaccaccug aaugcagagg aaaaucucua acuuccaagg ucccaccaac aguucagaaa      120

ccuaccacag uaaauguucc aacuacagaa gucucaccaa cuucucagaa aaccaccaca      180

aaaaccacca caccaaaugc ucaagguaca gagacuccau caguucuuca aaaacacacc      240

acagaaaaug uuucagcuac aagaacccca ccaacuccuc agaaacccac cacaguaaau      300

gucccagcua caauagucac accaacaccu cagaaaccca ccacaauaaa uguuccagcu      360

acaggagucu caucaacacc ucaaagacac accauaguaa auguuucagc uacaggaacc      420

cuaccaacuc uucagaaacc caccagagca aaugauucag ccaccaaauc cccagcagca      480

gcucagacau cuuucauauc aaaaacccua ucuacaaaga ccccuucugc agcucagaau      540

cccaugauga caaaugcuuc ugcuacacag gccacacuaa cagcccaaaa auucaccaca      600

gcaaaaguug cauuuacgca gaguccuuca gcagcaccaa cacggaguac accuguuucc      660

aggacaacca agcauuuuca ugaaacaacc ccaaauaaag gaaguggaac cacuucaggu      720

acuacccguc uucuaucugg gcacacgugu uucacguuga cagguuugcu ugggacgcua      780

guaaccaugg gcuugcugac uuag                                             804


<210>  925
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD55__Homo_sapiens__EAW93493

<400>  925
augaucggcg agcacagcau cuacugcacc gugaacaacg acgaggggga gugguccggg       60

cccccgcccg agugccgcgg caagagccug accuccaagg ucccgcccac ggugcagaag      120

cccaccaccg ugaacguccc caccacggag gugagcccca ccucccagaa gaccaccacg      180

aagaccacca cccccaacgc ccagggcacg gagaccccga gcgugcucca gaagcacacc      240

accgagaacg ucuccgccac gcggaccccg cccacgcccc agaagcccac caccgugaac      300

gugcccgcga ccaucgucac ccccacgccc cagaagccga ccaccaucaa cgugcccgcc      360

accgggguga gcuccacgcc ccagcgccac accaucguca acgugagcgc caccggcacc      420

cugcccaccc ugcagaagcc gacgcgggcc aacgacuccg ccaccaagag ccccgcggcc      480

gcccagaccu ccuucaucag caagacccuc uccacgaaga cccccagcgc cgcgcagaac      540

cccaugauga ccaacgccuc cgccacccag gccacccuga cggcccagaa guucaccacc      600

gcgaaggugg ccuucaccca gagcccgucc gccgccccca cgcgcagcac ccccgucagc      660

cggaccacca agcacuucca cgagacgacc cccaacaagg gcuccgggac caccagcggc      720

acgacccgcc ugcucuccgg gcacacgugc uucacccuga ccggccugcu cgggacccug      780

gugaccaugg gccugcucac cuga                                             804


<210>  926
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD55__Homo_sapiens__EAW93493

<400>  926
augaucggcg agcacuccau cuacugcacc gucaacaacg acgagggcga gugguccggc       60

cccccccccg agugccgcgg caagucccuc accuccaagg ucccccccac cguccagaag      120

cccaccaccg ucaacguccc caccaccgag gucuccccca ccucccagaa gaccaccacc      180

aagaccacca cccccaacgc ccagggcacc gagacccccu ccguccucca gaagcacacc      240

accgagaacg ucuccgccac ccgcaccccc cccacccccc agaagcccac caccgucaac      300

guccccgcca ccaucgucac ccccaccccc cagaagccca ccaccaucaa cguccccgcc      360

accggcgucu ccuccacccc ccagcgccac accaucguca acgucuccgc caccggcacc      420

cuccccaccc uccagaagcc cacccgcgcc aacgacuccg ccaccaaguc ccccgccgcc      480

gcccagaccu ccuucaucuc caagacccuc uccaccaaga cccccuccgc cgcccagaac      540

cccaugauga ccaacgccuc cgccacccag gccacccuca ccgcccagaa guucaccacc      600

gccaaggucg ccuucaccca gucccccucc gccgccccca cccgcuccac ccccgucucc      660

cgcaccacca agcacuucca cgagaccacc cccaacaagg gcuccggcac caccuccggc      720

accacccgcc uccucuccgg ccacaccugc uucacccuca ccggccuccu cggcacccuc      780

gucaccaugg gccuccucac cuga                                             804


<210>  927
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD55__Homo_sapiens__EAW93493

<400>  927
augaucggcg agcacagcau uuacugcacc gugaacaaug acgaagggga gugguccgga       60

cccccuccag aauguagagg uaagucucug acaucaaaag ucccgcccac uguucagaag      120

ccuacgaccg ugaacguacc aacaacugag gugaguccca ccagccagaa aacaaccacu      180

aagacaacca cgccuaaugc ccaaggcacu gaaaccccau ccguccucca gaaacauaca      240

acugagaacg ugucugcuac caggacaccc ccuaccccac agaagccgac gacuguuaau      300

gugcccgcaa caauagucac cccuacucca caaaagccca caaccaucaa cgugccugcc      360

acggggguau cgucaacccc acagcggcac acaauuguua augugagcgc gacuggaacc      420

cuucccacac ugcagaaacc gacucgcgcu aacgauagug ccaccaaguc cccugcagcc      480

gcucagacau cuuucaucag caaaaccuug uccacuaaga cgcccucagc agcccaaaau      540

ccaaugauga caaacgcuag ugccacccag gcgacuuuaa ccgcacagaa auuuacaacc      600

gccaaggucg cuuucacuca gagcccuucu gccgcaccca cacgauccac gccaguguca      660

cguaccacua agcauuuuca cgagacaacc cccaauaaag gcagcgguac aaccaguggg      720

acuacgagac ugcuaucugg acauaccugc uucacacuca cuggccugcu uggcacccug      780

gugacaaugg gguugcucac uuga                                             804


<210>  928
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD55__Homo_sapiens__EAW93493

<400>  928
augaucggcg agcacagcau cuacugcacc gugaacaacg acgagggcga guggagcggc       60

cccccccccg agugcagagg caagagccug accagcaagg ugccccccac cgugcagaag      120

cccaccaccg ugaacgugcc caccaccgag gugagcccca ccagccagaa gaccaccacc      180

aagaccacca cccccaacgc ccagggcacc gagaccccca gcgugcugca gaagcacacc      240

accgagaacg ugagcgccac cagaaccccc cccacccccc agaagcccac caccgugaac      300

gugcccgcca ccaucgugac ccccaccccc cagaagccca ccaccaucaa cgugcccgcc      360

accggcguga gcagcacccc ccagagacac accaucguga acgugagcgc caccggcacc      420

cugcccaccc ugcagaagcc caccagagcc aacgacagcg ccaccaagag ccccgccgcc      480

gcccagacca gcuucaucag caagacccug agcaccaaga cccccagcgc cgcccagaac      540

cccaugauga ccaacgccag cgccacccag gccacccuga ccgcccagaa guucaccacc      600

gccaaggugg ccuucaccca gagccccagc gccgccccca ccagaagcac ccccgugagc      660

agaaccacca agcacuucca cgagaccacc cccaacaagg gcagcggcac caccagcggc      720

accaccagac ugcugagcgg ccacaccugc uucacccuga ccggccugcu gggcacccug      780

gugaccaugg gccugcugac cuga                                             804


<210>  929
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD55__Homo_sapiens__EAW93493

<400>  929
augaucggcg agcacagcau uuacugcacc gugaacaaug acgaagggga gugguccgga       60

cccccuccgg aauguagagg caagucucug acaagcaaag uucccccuac gguccagaag      120

cccaccacag ugaacgugcc uaccacagag gucuccccca ccucucagaa aacaaccacg      180

aagaccacaa ccccuaaugc ccaagggaca gaaaccccga gcgugcucca gaaacauacg      240

acagagaacg uuuccgcuac ccggacaccc ccuacacccc agaagccuac caccgugaau      300

guccccgcca cgaucgugac cccgacaccu caaaagccca ccacaauuaa cguuccugcg      360

accggagugu cuagcacgcc ccagcgccac acaaucguca auguguccgc uaccggcacc      420

cugcccacac uucagaaacc uaccagagcc aacgauagcg ccacaaaguc uccggcugcc      480

gcucagacgu ccuucauuag caaaacccug ucuacaaaga cccccuccgc cgcgcaaaau      540

ccuaugauga caaacgccag cgcuacccag gccacgcuca ccgcucagaa auuuacaacc      600

gccaaggugg cguucacaca gucucccucc gccgcuccua cccggagcac gcccgucucc      660

cgcacaacca agcauuuuca cgagacaacc ccgaauaaag ggucuggaac cacaagcggc      720

acgaccagac ugcuuuccgg ccauacaugc uucacccuga cagggcuccu gggaacccug      780

guuacgaugg gccuccugac auga                                             804


<210>  930
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__P08174

<400>  930

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  931
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD55__Homo_sapiens__AAA52168

<400>  931
augaccgucg cgcggccgag cgugcccgcg gcgcugcccc uccucgggga gcugccccgg       60

cugcugcugc uggugcuguu gugccugccg gccguguggg gugacugugg ccuuccccca      120

gauguaccua augcccagcc agcuuuggaa ggccguacaa guuuucccga ggauacugua      180

auaacguaca aaugugaaga aagcuuugug aaaauuccug gcgagaagga cucagugauc      240

ugccuuaagg gcagucaaug gucagauauu gaagaguucu gcaaucguag cugcgaggug      300

ccaacaaggc uaaauucugc aucccucaaa cagccuuaua ucacucagaa uuauuuucca      360

gucgguacug uuguggaaua ugagugccgu ccagguuaca gaagagaacc uucucuauca      420

ccaaaacuaa cuugccuuca gaauuuaaaa ugguccacag cagucgaauu uuguaaaaag      480

aaaucaugcc cuaauccggg agaaauacga aauggucaga uugauguacc agguggcaua      540

uuauuuggug caaccaucuc cuucucaugu aacacagggu acaaauuauu uggcucgacu      600

ucuaguuuuu gucuuauuuc aggcagcucu guccagugga gugacccguu gccagagugc      660

agagaaauuu auuguccagc accaccacaa auugacaaug gaauaauuca aggggaacgu      720

gaccauuaug gauauagaca gucuguaacg uaugcaugua auaaaggauu caccaugauu      780

ggagagcacu cuauuuauug uacugugaau aaugaugaag gagaguggag uggcccacca      840

ccugaaugca gaggaaaauc ucuaacuucc aaggucccac caacaguuca gaaaccuacc      900

acaguaaaug uuccaacuac agaagucuca ccaacuucuc agaaaaccac cacaaaaacc      960

accacaccaa augcucaagc aacacggagu acaccuguuu ccaggacaac caagcauuuu     1020

caugaaacaa ccccaaauaa aggaagugga accacuucag guacuacccg ucuucuaucu     1080

gggcacacgu guuucacguu gacagguuug cuugggacgc uaguaaccau gggcuugcug     1140

acuuag                                                                1146


<210>  932
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD55__Homo_sapiens__AAA52168

<400>  932
augaccgugg cccgccccag cgucccggcc gcgcugcccc uccugggcga gcugccccgg       60

cuccugcugc ucgugcugcu gugccucccc gccguguggg gcgacugcgg gcugccgccc      120

gacgucccca acgcccagcc cgcccuggag gggcgcaccu ccuucccgga ggacacggug      180

aucaccuaca agugcgagga gagcuucgug aagauccccg gcgagaagga cuccgucauc      240

ugccucaagg ggagccagug guccgacauc gaggaguucu gcaaccggag cugcgaggug      300

cccacccgcc ugaacuccgc cagccugaag cagcccuaca ucacccagaa cuacuucccg      360

gugggcacgg ucguggagua cgagugccgg cccggcuacc gccgggagcc cucccucagc      420

cccaagcuga ccugccugca gaaccucaag ugguccaccg cgguggaguu cugcaagaag      480

aaguccugcc cgaaccccgg ggagauccgc aacggccaga ucgacguccc cgggggcauc      540

cuguucgggg ccaccaucag cuucagcugc aacacgggcu acaagcuguu cggcuccacc      600

agcuccuucu gccucaucag cggguccagc gugcagugga gcgacccccu gccggagugc      660

cgggagaucu acugccccgc cccgccccag aucgacaacg gcaucaucca gggggagcgc      720

gaccacuacg gcuaccggca guccgugacc uacgccugca acaagggcuu caccaugauc      780

ggggagcaca gcaucuacug cacggucaac aacgacgagg gcgagugguc cgggcccccg      840

cccgagugcc gcggcaagag ccugaccucc aaggugccgc ccaccgugca gaagcccacc      900

acggucaacg ugcccaccac cgaggugagc cccaccuccc agaagacgac caccaagacc      960

acgaccccca acgcgcaggc cacccggagc acccccgucu cccgcacgac caagcacuuc     1020

cacgagacca cccccaacaa ggggagcggc acgaccuccg gcaccacccg gcuccugagc     1080

gggcacacgu gcuucacccu gaccggccuc cuggggaccc uggugaccau gggccuccug     1140

acguga                                                                1146


<210>  933
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD55__Homo_sapiens__AAA52168

<400>  933
augaccgucg cccgccccuc cguccccgcc gcccuccccc uccucggcga gcucccccgc       60

cuccuccucc ucguccuccu cugccucccc gccgucuggg gcgacugcgg ccuccccccc      120

gacgucccca acgcccagcc cgcccucgag ggccgcaccu ccuuccccga ggacaccguc      180

aucaccuaca agugcgagga guccuucguc aagauccccg gcgagaagga cuccgucauc      240

ugccucaagg gcucccagug guccgacauc gaggaguucu gcaaccgcuc cugcgagguc      300

cccacccgcc ucaacuccgc cucccucaag cagcccuaca ucacccagaa cuacuucccc      360

gucggcaccg ucgucgagua cgagugccgc cccggcuacc gccgcgagcc cucccucucc      420

cccaagcuca ccugccucca gaaccucaag ugguccaccg ccgucgaguu cugcaagaag      480

aaguccugcc ccaaccccgg cgagauccgc aacggccaga ucgacguccc cggcggcauc      540

cucuucggcg ccaccaucuc cuucuccugc aacaccggcu acaagcucuu cggcuccacc      600

uccuccuucu gccucaucuc cggcuccucc guccaguggu ccgacccccu ccccgagugc      660

cgcgagaucu acugccccgc ccccccccag aucgacaacg gcaucaucca gggcgagcgc      720

gaccacuacg gcuaccgcca guccgucacc uacgccugca acaagggcuu caccaugauc      780

ggcgagcacu ccaucuacug caccgucaac aacgacgagg gcgagugguc cggccccccc      840

cccgagugcc gcggcaaguc ccucaccucc aagguccccc ccaccgucca gaagcccacc      900

accgucaacg uccccaccac cgaggucucc cccaccuccc agaagaccac caccaagacc      960

accaccccca acgcccaggc cacccgcucc acccccgucu cccgcaccac caagcacuuc     1020

cacgagacca cccccaacaa gggcuccggc accaccuccg gcaccacccg ccuccucucc     1080

ggccacaccu gcuucacccu caccggccuc cucggcaccc ucgucaccau gggccuccuc     1140

accuga                                                                1146


<210>  934
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD55__Homo_sapiens__AAA52168

<400>  934
augaccgugg ccagacccag cgucccugcu gcacugccac uccuuggcga gcugccgagg       60

uuguuacugc uaguucuccu gugccuuccc gccguguggg gagacugugg gcugccucca      120

gauguaccca acgcgcagcc ugcuuuggaa ggucggacau ccuucccaga ggacacugug      180

aucacguaca agugcgaaga gucuuuuguc aaaauucccg gcgaaaagga uucagugaua      240

ugucucaaag ggagucaaug gagcgacauc gaggaguucu gcaaucgcuc cugugaaguu      300

ccuacccgac ugaacucugc cucgcugaag cagccauaua uuacacagaa uuacuuuccg      360

gugggaacug ucguggagua ugaaugccgu cccggcuaca gaagggagcc uucacucagc      420

ccaaaauuaa ccugucugca gaaccuuaag uggaguacag caguagaguu cugcaagaaa      480

aaguccuguc ccaauccugg ugaaauccgg aacgggcaaa uugauguucc aggaggcauc      540

uuguuuggcg ccaccauauc uuucagcugc aauacugggu auaaacuguu uggauccaca      600

ucaaguuucu gucuaaucag cgguucuucc gugcaguggu cagacccccu cccggagugc      660

cgcgaaauuu acugcccugc ucccccacag aucgauaacg gcauuaucca gggggagaga      720

gaccacuaug gauacaggca aagcgucacc uacgcaugua auaagggcuu uacgaugaua      780

ggugaacaua guauuuauug cacugugaac aaugaugagg gggagugguc uggaccuccc      840

ccagaauguc ggggcaaauc ccugaccagc aaggugcccc cuacagucca gaagccaacu      900

accguuaacg ugccgacaac cgagguaucg cccacgucuc agaaaacuac aaccaagacu      960

acaaccccua augcccaggc uacgcgcucc accccagugu cacgaacaac uaaacacuuc     1020

caugaaacca cacccaacaa gggcaguggg acuaccagcg gaacaaccag acuucugucc     1080

ggucacacuu gcuuuacguu gacaggccuc cuggggaccu uagucacuau gggacugcuc     1140

accuga                                                                1146


<210>  935
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD55__Homo_sapiens__AAA52168

<400>  935
augaccgugg ccagacccag cgugcccgcc gcccugcccc ugcugggcga gcugcccaga       60

cugcugcugc uggugcugcu gugccugccc gccguguggg gcgacugcgg ccugcccccc      120

gacgugccca acgcccagcc cgcccuggag ggcagaacca gcuuccccga ggacaccgug      180

aucaccuaca agugcgagga gagcuucgug aagauccccg gcgagaagga cagcgugauc      240

ugccugaagg gcagccagug gagcgacauc gaggaguucu gcaacagaag cugcgaggug      300

cccaccagac ugaacagcgc cagccugaag cagcccuaca ucacccagaa cuacuucccc      360

gugggcaccg ugguggagua cgagugcaga cccggcuaca gaagagagcc cagccugagc      420

cccaagcuga ccugccugca gaaccugaag uggagcaccg ccguggaguu cugcaagaag      480

aagagcugcc ccaaccccgg cgagaucaga aacggccaga ucgacgugcc cggcggcauc      540

cuguucggcg ccaccaucag cuucagcugc aacaccggcu acaagcuguu cggcagcacc      600

agcagcuucu gccugaucag cggcagcagc gugcagugga gcgacccccu gcccgagugc      660

agagagaucu acugccccgc ccccccccag aucgacaacg gcaucaucca gggcgagaga      720

gaccacuacg gcuacagaca gagcgugacc uacgccugca acaagggcuu caccaugauc      780

ggcgagcaca gcaucuacug caccgugaac aacgacgagg gcgaguggag cggccccccc      840

cccgagugca gaggcaagag ccugaccagc aaggugcccc ccaccgugca gaagcccacc      900

accgugaacg ugcccaccac cgaggugagc cccaccagcc agaagaccac caccaagacc      960

accaccccca acgcccaggc caccagaagc acccccguga gcagaaccac caagcacuuc     1020

cacgagacca cccccaacaa gggcagcggc accaccagcg gcaccaccag acugcugagc     1080

ggccacaccu gcuucacccu gaccggccug cugggcaccc uggugaccau gggccugcug     1140

accuga                                                                1146


<210>  936
<211>  1146
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD55__Homo_sapiens__AAA52168

<400>  936
augaccgugg ccagacccag cgucccugcu gcccugccgc uccugggcga gcuuccccgg       60

cugcuccugc uuguucugcu cugccugccu gcgguguggg gagacugugg gcugcccccu      120

gaugugccca acgcucagcc ugcccucgaa ggccgcacau ccuucccgga ggacacgguc      180

aucaccuaca agugcgaaga gucuuuugug aaaauucccg gggaaaagga uagcguuauc      240

ugucugaaag gaucccaaug gucugacauu gaggaguucu gcaauagaag cugugaagug      300

ccuacacggc uuaacuccgc cucucugaag cagcccuaua ucacccagaa uuacuuuccu      360

gucggcacag ugguugagua ugaaugccgc cccggguaca gacgggagcc gagccucucc      420

ccuaaacuga ccugucuuca gaaccugaag uggagcacag cuguggaguu cugcaagaaa      480

aagucuuguc ccaauccugg agaaauucgc aacggccaaa ucgauguccc cggcgggauc      540

cucuuuggag ccaccauuuc cuucagcugc aauacgggcu auaaacuguu ugggucuacc      600

uccagcuucu gucugaucuc uggauccagc gugcaguggu ccgacccccu cccugagugc      660

agagaaauuu acugcccggc ucccccucag aucgauaacg gcauuaucca gggggagcgg      720

gaccacuaug gauaccgcca aucugugaca uacgccugua auaagggcuu uaccaugauu      780

ggcgaacaua gcaucuauug cacagucaac aaugaugagg gggagugguc cggacccccu      840

cccgaaugua gaggcaaaag ccugaccucu aagguuccgc cuacggugca gaagcccaca      900

accgugaacg ucccuacaac cgaggugucc cccaccagcc agaaaacaac gaccaagaca      960

accacaccua augcgcaggc cacccggucu acgcccguua gccgcacaac caaacacuuc     1020

caugaaacca caccgaacaa gggguccgga accacaucug gcacgaccag acuucugagc     1080

gggcacacau gcuuuacccu cacaggacug cuuggcaccc uggugacgau gggccuccug     1140

accuga                                                                1146


<210>  937
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD56__Homo_sapiens__P13591

<400>  937

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  938
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD56__Homo_sapiens__CCDS73385.1

<400>  938
augcugcaaa cuaaggaucu caucuggacu uuguuuuucc ugggaacugc aguuucucug       60

cagguggaua uuguucccag ccagggggag aucagcguug gagaguccaa auucuucuua      120

ugccaagugg caggagaugc caaagauaaa gacaucuccu gguucucccc caauggagaa      180

aagcucaccc caaaccagca gcggaucuca guggugugga augaugauuc cuccuccacc      240

cucaccaucu auaacgccaa caucgacgac gccggcauuu acaagugugu gguuacaggc      300

gaggauggca gugagucaga ggccaccguc aacgugaaga ucuuucagaa gcucauguuc      360

aagaaugcgc caaccccaca ggaguuccgg gagggggaag augccgugau ugugugugau      420

guggucagcu cccucccacc aaccaucauc uggaaacaca aaggccgaga ugucauccug      480

aaaaaagaug uccgauucau aguccugucc aacaacuacc ugcagauccg gggcaucaag      540

aaaacagaug agggcacuua ucgcugugag ggcagaaucc uggcacgggg ggagaucaac      600

uucaaggaca uucaggucau ugugaaugug ccaccuacca uccaggccag gcagaauauu      660

gugaaugcca ccgccaaccu cggccagucc gucacccugg ugugcgaugc cgaaggcuuc      720

ccagagccca ccaugagcug gacaaaggau ggggaacaga uagagcaaga ggaagacgau      780

gagaaguaca ucuucagcga cgauaguucc cagcugacca ucaaaaaggu ggauaagaac      840

gacgaggcug aguacaucug cauugcugag aacaaggcug gcgagcagga ugcgaccauc      900

caccucaaag ucuuugcaaa acccaaaauc acauauguag agaaccagac ugccauggaa      960

uuagaggagc aggucacucu uaccugugaa gccuccggag accccauucc cuccaucacc     1020

uggaggacuu cuacccggaa caucagcagc gaagaaaagg cuucguggac ucgaccagag     1080

aagcaagaga cucuggaugg gcacauggug gugcguagcc augcccgugu gucgucgcug     1140

acccugaaga gcauccagua cacugaugcc ggagaguaca ucugcaccgc cagcaacacc     1200

aucggccagg acucccaguc cauguaccuu gaagugcaau augccccaaa gcuacagggc     1260

ccuguggcug uguacacuug ggaggggaac caggugaaca ucaccugcga gguauuugcc     1320

uaucccagug ccacgaucuc augguuucgg gauggccagc ugcugccaag cuccaauuac     1380

agcaauauca agaucuacaa cacccccucu gccagcuauc uggaggugac cccagacucu     1440

gagaaugauu uugggaacua caacuguacu gcagugaacc gcauugggca ggaguccuug     1500

gaauucaucc uuguucaagc agacaccccc ucuucaccau ccaucgacca gguggagcca     1560

uacuccagca cagcccaggu gcaguuugau gaaccagagg ccacaggugg ggugcccauc     1620

cucaaauaca aagcugagug gagagcaguu ggugaagaag uauggcauuc caagugguau     1680

gaugccaagg aagccagcau ggagggcauc gucaccaucg ugggccugaa gcccgaaaca     1740

acguacgccg uaaggcuggc ggcgcucaau ggcaaagggc ugggugagau cagcgcggcc     1800

uccgaguuca agacgcagcc aguccaaggg gaacccagug caccuaagcu cgaagggcag     1860

augggagagg auggaaacuc uauuaaagug aaccugauca agcaggauga cggcggcucc     1920

cccaucagac acuaucuggu cagguaccga gcgcucuccu ccgaguggaa accagagauc     1980

aggcucccgu cuggcaguga ccacgucaug cugaaguccc uggacuggaa ugcugaguau     2040

gaggucuacg ugguggcuga gaaccagcaa ggaaaaucca aggcggcuca uuuuguguuc     2100

aggaccucgg cccagcccac agccauccca gccaacggca gccccaccuc aggccugagc     2160

accggggcca ucgugggcau ccucaucguc aucuucgucc ugcuccuggu gguuguggac     2220

aucaccugcu acuuccugaa caaguguggc cuguucaugu gcauugcggu caaccugugu     2280

ggaaaagccg ggcccggggc caagggcaag gacauggagg agggcaaggc cgccuucucg     2340

aaagaugagu ccaaggagcc caucguggag guucgaacgg aggaggagag gaccccaaac     2400

caugauggag ggaaacacac agagcccaac gagaccacgc cacugacgga gcccgagaag     2460

ggccccguag aagcaaagcc agagugccag gagacagaaa cgaagccagc gccagccgaa     2520

gucaagacgg uccccaauga cgccacacag acaaaggaga acgagagcaa agcauga        2577


<210>  939
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD56__Homo_sapiens__CCDS73385.1

<400>  939
augcugcaga ccaaggaccu caucuggacc cuguucuucc ugggcacggc cgugagccuc       60

caggucgaca ucgugcccuc ccagggggag aucagcgugg gcgaguccaa guucuuccug      120

ugccaggucg ccggggacgc gaaggacaag gacaucagcu gguucucccc gaacggcgag      180

aagcugaccc ccaaccagca gcgcaucagc guggugugga acgacgacuc cagcuccacc      240

cucaccaucu acaacgccaa caucgacgac gccgggaucu acaagugcgu cgugacgggc      300

gaggacggca gcgaguccga ggccaccgug aacgucaaga ucuuccagaa gcugauguuc      360

aagaacgccc ccacgcccca ggaguuccgg gagggggagg acgcggugau cgugugcgac      420

gucgugagcu cccugccgcc caccaucauc uggaagcaca agggccgcga cgugauccuc      480

aagaaggacg uccgguucau cgugcugagc aacaacuacc ugcagauccg cgggaucaag      540

aagaccgacg agggcaccua ccggugcgag gggcgcaucc ucgcccgggg cgagaucaac      600

uucaaggaca uccaggugau cgucaacgug ccgcccacca uccaggcccg ccagaacauc      660

gugaacgcca ccgcgaaccu gggccagucc gucacgcugg ugugcgacgc cgagggguuc      720

cccgagccca ccaugagcug gaccaaggac ggcgagcaga ucgagcagga ggaggacgac      780

gagaaguaca ucuucuccga cgacagcucc cagcucacca ucaagaaggu ggacaagaac      840

gacgaggccg aguacaucug caucgccgag aacaaggccg gggagcagga cgcgacgauc      900

caccugaagg ucuucgccaa gcccaagauc accuacgugg agaaccagac cgccauggag      960

cuggaggagc aggucacccu cacgugcgag gccagcggcg accccauccc gagcaucacc     1020

uggcggaccu ccacccgcaa caucagcucc gaggagaagg ccagcuggac gcggcccgag     1080

aagcaggaga cccuggacgg ccacauggug gugcgcuccc acgcgcgggu cagcucccug     1140

acccucaaga gcauccagua caccgacgcc ggggaguaca ucugcacggc cuccaacacc     1200

aucggccagg acagccaguc cauguaccug gaggugcagu acgcccccaa gcugcagggg     1260

cccguggccg ucuacaccug ggagggcaac caggugaaca ucacgugcga gguguucgcg     1320

uacccgagcg ccaccaucuc cugguuccgc gacgggcagc uccugcccag cuccaacuac     1380

agcaacauca agaucuacaa cacccccucc gccagcuacc uggaggucac ccccgacucc     1440

gagaacgacu ucggcaacua caacugcacc gccgugaacc ggaucggcca ggagagccuc     1500

gaguucaucc uggugcaggc cgacacgccg agcuccccca gcaucgacca ggucgagccc     1560

uacuccagca ccgcccaggu gcaguucgac gagcccgagg cgaccggggg cgugccgauc     1620

cugaaguaca aggccgagug gcgcgccguc ggggaggagg uguggcacuc caagugguac     1680

gacgcgaagg aggccagcau ggagggcauc gugaccaucg ucgggcucaa gcccgagacc     1740

acguacgccg ugcggcuggc cgcccugaac ggcaagggcc ucggggagau cuccgcggcc     1800

agcgaguuca agacccagcc cgugcagggc gagcccuccg ccccgaagcu ggaggggcag     1860

augggcgagg acgggaacag caucaagguc aaccugauca agcaggacga cggcggcucc     1920

cccauccgcc acuaccucgu gcgguaccgc gcccugagcu ccgaguggaa gcccgagauc     1980

cggcugccga gcggguccga ccacgugaug cucaagagcc uggacuggaa cgccgaguac     2040

gaggucuacg ugguggcgga gaaccagcag ggcaagucca aggccgccca cuucgucuuc     2100

cgcaccagcg cccagcccac cgccaucccc gcgaacggga gccccacguc cggccugagc     2160

accggcgcca ucguggggau ccucaucgug aucuucgucc ugcugcucgu gguggucgac     2220

aucacgugcu acuuccugaa caagugcggc cuguucaugu gcaucgccgu gaaccucugc     2280

gggaaggccg gcccgggggc gaagggcaag gacauggagg agggcaaggc cgccuucucc     2340

aaggacgaga gcaaggagcc caucguggag guccgcaccg aggaggagcg gacccccaac     2400

cacgacgggg gcaagcacac cgagcccaac gagaccaccc cgcugacgga gcccgagaag     2460

gggcccgugg aggccaagcc cgagugccag gagaccgaga ccaagccggc ccccgcggag     2520

gugaagaccg uccccaacga cgccacgcag accaaggaga acgaguccaa ggccuga        2577


<210>  940
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD56__Homo_sapiens__CCDS73385.1

<400>  940
augcuccaga ccaaggaccu caucuggacc cucuucuucc ucggcaccgc cgucucccuc       60

caggucgaca ucguccccuc ccagggcgag aucuccgucg gcgaguccaa guucuuccuc      120

ugccaggucg ccggcgacgc caaggacaag gacaucuccu gguucucccc caacggcgag      180

aagcucaccc ccaaccagca gcgcaucucc gucgucugga acgacgacuc cuccuccacc      240

cucaccaucu acaacgccaa caucgacgac gccggcaucu acaagugcgu cgucaccggc      300

gaggacggcu ccgaguccga ggccaccguc aacgucaaga ucuuccagaa gcucauguuc      360

aagaacgccc ccacccccca ggaguuccgc gagggcgagg acgccgucau cgucugcgac      420

gucgucuccu cccucccccc caccaucauc uggaagcaca agggccgcga cgucauccuc      480

aagaaggacg uccgcuucau cguccucucc aacaacuacc uccagauccg cggcaucaag      540

aagaccgacg agggcaccua ccgcugcgag ggccgcaucc ucgcccgcgg cgagaucaac      600

uucaaggaca uccaggucau cgucaacguc ccccccacca uccaggcccg ccagaacauc      660

gucaacgcca ccgccaaccu cggccagucc gucacccucg ucugcgacgc cgagggcuuc      720

cccgagccca ccauguccug gaccaaggac ggcgagcaga ucgagcagga ggaggacgac      780

gagaaguaca ucuucuccga cgacuccucc cagcucacca ucaagaaggu cgacaagaac      840

gacgaggccg aguacaucug caucgccgag aacaaggccg gcgagcagga cgccaccauc      900

caccucaagg ucuucgccaa gcccaagauc accuacgucg agaaccagac cgccauggag      960

cucgaggagc aggucacccu caccugcgag gccuccggcg accccauccc cuccaucacc     1020

uggcgcaccu ccacccgcaa caucuccucc gaggagaagg ccuccuggac ccgccccgag     1080

aagcaggaga cccucgacgg ccacaugguc guccgcuccc acgcccgcgu cuccucccuc     1140

acccucaagu ccauccagua caccgacgcc ggcgaguaca ucugcaccgc cuccaacacc     1200

aucggccagg acucccaguc cauguaccuc gagguccagu acgcccccaa gcuccagggc     1260

cccgucgccg ucuacaccug ggagggcaac caggucaaca ucaccugcga ggucuucgcc     1320

uaccccuccg ccaccaucuc cugguuccgc gacggccagc uccuccccuc cuccaacuac     1380

uccaacauca agaucuacaa cacccccucc gccuccuacc ucgaggucac ccccgacucc     1440

gagaacgacu ucggcaacua caacugcacc gccgucaacc gcaucggcca ggagucccuc     1500

gaguucaucc ucguccaggc cgacaccccc uccucccccu ccaucgacca ggucgagccc     1560

uacuccucca ccgcccaggu ccaguucgac gagcccgagg ccaccggcgg cguccccauc     1620

cucaaguaca aggccgagug gcgcgccguc ggcgaggagg ucuggcacuc caagugguac     1680

gacgccaagg aggccuccau ggagggcauc gucaccaucg ucggccucaa gcccgagacc     1740

accuacgccg uccgccucgc cgcccucaac ggcaagggcc ucggcgagau cuccgccgcc     1800

uccgaguuca agacccagcc cguccagggc gagcccuccg cccccaagcu cgagggccag     1860

augggcgagg acggcaacuc caucaagguc aaccucauca agcaggacga cggcggcucc     1920

cccauccgcc acuaccucgu ccgcuaccgc gcccucuccu ccgaguggaa gcccgagauc     1980

cgccuccccu ccggcuccga ccacgucaug cucaaguccc ucgacuggaa cgccgaguac     2040

gaggucuacg ucgucgccga gaaccagcag ggcaagucca aggccgccca cuucgucuuc     2100

cgcaccuccg cccagcccac cgccaucccc gccaacggcu cccccaccuc cggccucucc     2160

accggcgcca ucgucggcau ccucaucguc aucuucgucc uccuccucgu cgucgucgac     2220

aucaccugcu acuuccucaa caagugcggc cucuucaugu gcaucgccgu caaccucugc     2280

ggcaaggccg gccccggcgc caagggcaag gacauggagg agggcaaggc cgccuucucc     2340

aaggacgagu ccaaggagcc caucgucgag guccgcaccg aggaggagcg cacccccaac     2400

cacgacggcg gcaagcacac cgagcccaac gagaccaccc cccucaccga gcccgagaag     2460

ggccccgucg aggccaagcc cgagugccag gagaccgaga ccaagcccgc ccccgccgag     2520

gucaagaccg uccccaacga cgccacccag accaaggaga acgaguccaa ggccuga        2577


<210>  941
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD56__Homo_sapiens__CCDS73385.1

<400>  941
augcugcaga ccaaggaccu caucuggaca cuuuucuuuc ugggcacugc cgugagcuug       60

caagucgaua uuguucccuc ccagggggag auaucugugg gagaaucaaa auucuuuuua      120

ugccagguag cuggugacgc aaaggauaaa gacaucaguu gguucagccc uaacggcgag      180

aagcugacgc caaaucagca aagaauuucc guggucugga acgaugacuc uucgucaacc      240

cuaacaaucu acaaugccaa cauugaugac gcggggaucu auaaaugugu gguuacugga      300

gaagauggca gcgagaguga agcuaccgug aaugucaaga uauuucagaa gcucauguuc      360

aaaaacgccc cgacacccca ggaguuuagg gagggugaag acgcagugau cguaugcgau      420

guuguguccu cucugccucc aaccauuauc uggaagcaca aagggcggga cgucauucuu      480

aagaaagaug ugcgcuucau cgugcugagc aauaacuacu ugcagauacg aggaauuaag      540

aagacugacg agggcacaua ucguugugaa ggcagaaucc ucgcccgcgg ggagauuaau      600

uuuaaagaca uccaagucau cguuaacgug cccccuacca uucaggcucg gcagaauaua      660

guaaacgcaa cggccaaucu gggacagucc gugacucugg ucugcgaugc ugaggguuuc      720

ccagaaccca ccaugucaug gacaaaggac ggcgagcaaa ucgaacagga ggaagaugac      780

gagaaauaca uuuuuaguga ugacagcucu cagcucacua ucaagaaagu ggauaagaac      840

gacgaggccg aauauauaug uauugcggag aauaaagcag gggaacaaga ugccaccauc      900

cauuuaaagg uuuucgcuaa gccuaaaauc acauacgugg agaaccagac cgccauggaa      960

cuggaggagc aggucacgcu uacuugcgaa gcauccggag acccaauucc gucaaucaca     1020

uggcgcacca gcacuagaaa cauuaguucu gaggaaaagg cuuccuggac aaggcccgag     1080

aaacaggaaa ccuuggaugg ccacauggug guacggagcc augcccgcgu uucgucucug     1140

acgcuaaagu ccauacaaua uaccgacgcg ggugaguaca ucuguacagc cucaaauacu     1200

auugggcagg acagucagag cauguaccuc gaggugcagu augcaccuaa acugcaagga     1260

ccagucgcug uguacaccug ggaaggcaac caggucaaua ucacaugcga gguguuugcc     1320

uaucccuccg cuacuaucuc uugguuccga gauggccagc uucugccuag cucaaacuac     1380

aguaauauua agauauauaa caccccaucc gccagcuacu uggaaguuac acccgacucu     1440

gagaaugauu ucgggaacua uaauuguacc gcagugaaca gaaucggaca ggagucacuc     1500

gaauuuauuc ugguacaagc cgacacuccg aguagcccuu ccaucgauca ggucgagccc     1560

uacucuucga cggcucaggu gcaguucgac gaaccagagg cgacaggugg cguuccuauu     1620

uuaaaguaca aagcagaaug gagggccgug ggggaggagg ucuggcacag caagugguau     1680

gaugcuaaag aagccuccau ggagggaauc gugaccauag uaggccugaa gcccgaaacu     1740

accuacgcag ugcggcucgc cgcucuuaau gguaaagggc ugggcgagau cucagccgca     1800

agugaauuua agacacaacc aguucaggga gagcccucug cgccuaaguu ggagggccag     1860

augggggaag acggaaacag cauuaaaguc aaucuaauca agcaagauga cgguggcucc     1920

ccaauucguc auuaucuggu gcgcuacaga gcucucucaa gcgaguggaa accggaaauc     1980

aggcugcccu cuggguccga ucacgugaug cuuaagaguc uggacuggaa cgccgaguau     2040

gaagucuacg uuguggcaga gaaucagcag ggaaaaagca aggccgcuca cuucguguuu     2100

cggaccucug cccagccuac ugcaauacca gcuaacggcu cccccacauc agguuugagu     2160

acgggggcca uuguaggcau ccucauuguc aucuucgugc uguuacuggu uguggucgau     2220

auaaccugcu auuuucuaaa caagugugga cucuucaugu gcaucgcggu gaaucugugc     2280

ggcaaagccg ggccuggagc uaaggguaaa gacauggagg aaggcaaggc agccuuuagc     2340

aaagacgagu cgaaggaacc aauuguugag gugcgaacug aggaagagag gacacccaac     2400

caugaugggg gaaaacacac cgaaccgaau gagacaacuc cucuuaccga accagagaag     2460

ggccccguag aggcuaagcc ugaaugucaa gagacggaaa ccaaacccgc cccagcagag     2520

gucaagacag ugccuaacga cgcgacucag accaaagaaa augaguccaa ggccuga        2577


<210>  942
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD56__Homo_sapiens__CCDS73385.1

<400>  942
augcugcaga ccaaggaccu gaucuggacc cuguucuucc ugggcaccgc cgugagccug       60

cagguggaca ucgugcccag ccagggcgag aucagcgugg gcgagagcaa guucuuccug      120

ugccaggugg ccggcgacgc caaggacaag gacaucagcu gguucagccc caacggcgag      180

aagcugaccc ccaaccagca gagaaucagc guggugugga acgacgacag cagcagcacc      240

cugaccaucu acaacgccaa caucgacgac gccggcaucu acaagugcgu ggugaccggc      300

gaggacggca gcgagagcga ggccaccgug aacgugaaga ucuuccagaa gcugauguuc      360

aagaacgccc ccacccccca ggaguucaga gagggcgagg acgccgugau cgugugcgac      420

guggugagca gccugccccc caccaucauc uggaagcaca agggcagaga cgugauccug      480

aagaaggacg ugagauucau cgugcugagc aacaacuacc ugcagaucag aggcaucaag      540

aagaccgacg agggcaccua cagaugcgag ggcagaaucc uggccagagg cgagaucaac      600

uucaaggaca uccaggugau cgugaacgug ccccccacca uccaggccag acagaacauc      660

gugaacgcca ccgccaaccu gggccagagc gugacccugg ugugcgacgc cgagggcuuc      720

cccgagccca ccaugagcug gaccaaggac ggcgagcaga ucgagcagga ggaggacgac      780

gagaaguaca ucuucagcga cgacagcagc cagcugacca ucaagaaggu ggacaagaac      840

gacgaggccg aguacaucug caucgccgag aacaaggccg gcgagcagga cgccaccauc      900

caccugaagg uguucgccaa gcccaagauc accuacgugg agaaccagac cgccauggag      960

cuggaggagc aggugacccu gaccugcgag gccagcggcg accccauccc cagcaucacc     1020

uggagaacca gcaccagaaa caucagcagc gaggagaagg ccagcuggac cagacccgag     1080

aagcaggaga cccuggacgg ccacauggug gugagaagcc acgccagagu gagcagccug     1140

acccugaaga gcauccagua caccgacgcc ggcgaguaca ucugcaccgc cagcaacacc     1200

aucggccagg acagccagag cauguaccug gaggugcagu acgcccccaa gcugcagggc     1260

cccguggccg uguacaccug ggagggcaac caggugaaca ucaccugcga gguguucgcc     1320

uaccccagcg ccaccaucag cugguucaga gacggccagc ugcugcccag cagcaacuac     1380

agcaacauca agaucuacaa cacccccagc gccagcuacc uggaggugac ccccgacagc     1440

gagaacgacu ucggcaacua caacugcacc gccgugaaca gaaucggcca ggagagccug     1500

gaguucaucc uggugcaggc cgacaccccc agcagcccca gcaucgacca gguggagccc     1560

uacagcagca ccgcccaggu gcaguucgac gagcccgagg ccaccggcgg cgugcccauc     1620

cugaaguaca aggccgagug gagagccgug ggcgaggagg uguggcacag caagugguac     1680

gacgccaagg aggccagcau ggagggcauc gugaccaucg ugggccugaa gcccgagacc     1740

accuacgccg ugagacuggc cgcccugaac ggcaagggcc ugggcgagau cagcgccgcc     1800

agcgaguuca agacccagcc cgugcagggc gagcccagcg cccccaagcu ggagggccag     1860

augggcgagg acggcaacag caucaaggug aaccugauca agcaggacga cggcggcagc     1920

cccaucagac acuaccuggu gagauacaga gcccugagca gcgaguggaa gcccgagauc     1980

agacugccca gcggcagcga ccacgugaug cugaagagcc uggacuggaa cgccgaguac     2040

gagguguacg ugguggccga gaaccagcag ggcaagagca aggccgccca cuucguguuc     2100

agaaccagcg cccagcccac cgccaucccc gccaacggca gccccaccag cggccugagc     2160

accggcgcca ucgugggcau ccugaucgug aucuucgugc ugcugcuggu ggugguggac     2220

aucaccugcu acuuccugaa caagugcggc cuguucaugu gcaucgccgu gaaccugugc     2280

ggcaaggccg gccccggcgc caagggcaag gacauggagg agggcaaggc cgccuucagc     2340

aaggacgaga gcaaggagcc caucguggag gugagaaccg aggaggagag aacccccaac     2400

cacgacggcg gcaagcacac cgagcccaac gagaccaccc cccugaccga gcccgagaag     2460

ggccccgugg aggccaagcc cgagugccag gagaccgaga ccaagcccgc ccccgccgag     2520

gugaagaccg ugcccaacga cgccacccag accaaggaga acgagagcaa ggccuga        2577


<210>  943
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD56__Homo_sapiens__CCDS73385.1

<400>  943
augcugcaga ccaaggaccu caucuggaca cuguucuuuc uuggcacggc cgugagccug       60

caagucgaua uuguucccuc ccagggggag aucucugugg gagaaagcaa auucuuucuc      120

ugccaggugg cuggcgacgc caaggauaaa gacauuuccu gguucucucc uaacggggag      180

aagcugaccc cgaaucagca aagaaucagc gucgugugga acgaugacuc cucuagcaca      240

cuuaccauuu acaaugcgaa caucgaugac gcuggaaucu auaaaugugu ugugacaggc      300

gaagaugggu ccgagagcga agccaccguc aaugugaaga uuuuucagaa gcugauguuc      360

aaaaacgccc ccacaccuca ggaguuucgg gagggagaag acgcuguuau cgugugcgau      420

gucgugucuu cccugccccc uaccauuauc uggaagcaca aaggccgcga cgugauucuc      480

aagaaagaug ucagauucau cguucugagc aauaacuacc uccagauucg gggcaucaag      540

aagacggacg aggggaccua ucgcugugaa ggaagaaucc uggcccgggg cgagauuaau      600

uuuaaagaca uccaagugau ugugaacgug cccccuacaa uccaggcucg ccagaauauu      660

gugaacgcca ccgcgaaucu ugggcagucu guuacacugg ugugcgaugc cgagggauuc      720

ccggaaccca ccauguccug gacgaaggac ggcgagcaaa ucgaacagga ggaagaugac      780

gagaaauaca ucuuuagcga ugacucuucc cagcucacaa uuaagaaagu cgauaagaac      840

gacgaggcug aauauaucug uauugccgag aauaaagcug gggaacaaga ugccaccauc      900

caucugaagg uguucgcgaa gccuaaaauu acauacguug agaaccagac cgccauggaa      960

cuugaggagc aggucacccu gacaugcgaa gcuagcggag accccauccc uuccaucacg     1020

uggagaaccu cuacacggaa cauuagcucc gaggaaaagg ccagcuggac ccgccccgag     1080

aaacaggaaa cacucgaugg ccacaugguc gugagaucuc augcucgggu cuccagccug     1140

acccugaagu cuauccaaua uacggacgcc ggcgaguaca uuuguacagc cagcaauacc     1200

aucgggcagg acucccaguc uauguaccuc gaggugcagu augcuccgaa acugcaagga     1260

ccuguugcgg uguacaccug ggaaggcaac caggucaaua uuacaugcga gguguuugcc     1320

uaucccagcg cuaccaucuc cugguuccgc gaugggcagc uucugccuag cucuaacuac     1380

uccaauauua agaucuauaa cacacccagc gccucuuacc ucgaaguuac gcccgacucc     1440

gagaaugauu ucggaaacua uaauuguacc gccgugaaca gaaucggcca ggagagccug     1500

gaauuuauuc uuguccaagc ugacacaccu uccucuccga gcaucgauca gguggagccc     1560

uacuccucua ccgcccaggu gcaguucgac gaaccugagg cgacaggggg aguucccauu     1620

cugaaguaca aagcugaaug gcgggccguc ggcgaggagg uguggcacag caagugguau     1680

gaugccaaag aggcuuccau ggagggcauc gugaccauug ucgggcucaa gccugaaacg     1740

accuacgccg ugcgccuggc ugcccugaau ggaaaaggcc ucggggagau cagcgcggcc     1800

ucugaauuua agacacaacc cguucaggga gagccguccg cuccuaagcu ggagggccag     1860

augggggaag acggcaacag caucaaagug aaucuuauua agcaagauga cggaggcucu     1920

cccaucagac auuaucuggu ccgguacaga gcccucucca gcgaguggaa accugaaauu     1980

cgccugcccu cugggagcga ucacgugaug cuuaaguccc uggacuggaa cgcugaguau     2040

gaaguuuacg uggucgccga gaaucagcag ggaaaaagca aggcggccca cuucguguuu     2100

cggaccucug cucagccuac agccaucccc gcuaacggcu ccccgaccag cgggcucucc     2160

acgggagcca uuguuggcau ccugaucgug auuuucgucc ugcuccuggu gguggucgau     2220

aucacaugcu auuuucuuaa caaguguggg cuguucaugu gcauugccgu uaaucucugc     2280

ggcaaagcug gaccuggcgc gaaggggaaa gacauggagg aaggaaaggc cgcuuuuucu     2340

aaagacgaga gcaaggaacc caucguggag gugagaaccg aggaagaacg cacacccaac     2400

caugauggcg ggaaacacac cgaaccuaau gagaccacac cgcugacgga acccgagaag     2460

ggaccugucg aggccaagcc cgaaugucaa gagaccgaaa caaaaccugc ccccgcugag     2520

gugaagaccg uuccuaacga cgccacacag accaaagaaa augaguccaa ggcguga        2577


<210>  944
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD80__Homo_sapiens__A0N0P2

<400>  944

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             






<210>  945
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD80__Homo_sapiens__ABK41933

<400>  945
augggccaca cacggaggca gggaacauca ccauccaagu guccauaccu caauuucuuu       60

cagcucuugg ugcuggcugg ucuuucucac uucuguucag guguuaucca cgugaccaag      120

gaagugaaag aaguggcaac gcuguccugu ggucacaaug uuucuguuga agagcuggca      180

caaacucgca ucuacuggca aaaggagaag aaaauggugc ugacuaugau gucuggggac      240

augaauauau ggcccgagua caagaaccgg accaucuuug auaucacuaa uaaccucucc      300

auugugaucc uggcucugcg cccaucugac gagggcacau acgagugugu uguucugaag      360

uaugaaaaag acgcuuucaa gcgggaacac cuggcugaag ugacguuauc agucaaagcu      420

gacuucccua caccuaguau aucugacuuu gaaauuccaa cuucuaauau uagaaggaua      480

auuugcucaa ccucuggagg uuuuccagag ccucaccucu ccugguugga aaauggagaa      540

gaauuaaaug ccaucaacac aacaguuucc caagauccug aaacugagcu cuaugcuguu      600

agcagcaaac uggauuucaa uaugacaacc aaccacagcu ucaugugucu caucaaguau      660

ggacauuuaa gagugaauca gaccuucaac uggaauacaa ccaagcaaga gcauuuuccu      720

gauaaccugc ucccauccug ggccauuacc uuaaucucag uaaauggaau uuuugugaua      780

ugcugccuga ccuacugcuu ugccccaaga ugcagagaga gaaggaggaa ugagagauug      840

agaagggaaa guguacgccc uguauaa                                          867


<210>  946
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD80__Homo_sapiens__ABK41933

<400>  946
augggccaca cccgccggca ggggaccagc cccuccaagu gcccguaccu gaacuucuuc       60

cagcuccugg ugcuggccgg ccucagccac uucugcuccg gggucaucca cgugacgaag      120

gaggugaagg aggucgccac ccugagcugc ggccacaacg uguccgugga ggagcuggcc      180

cagacccgca ucuacuggca gaaggagaag aagauggucc ucaccaugau gagcggggac      240

augaacaucu ggcccgagua caagaaccgg acgaucuucg acaucaccaa caaccugucc      300

aucgugaucc uggcccuccg ccccagcgac gagggcaccu acgagugcgu gguccugaag      360

uacgagaagg acgccuucaa gcgggagcac cuggccgagg ugacccucuc cgugaaggcc      420

gacuucccca cgccgagcau cuccgacuuc gagaucccca ccagcaacau ccgccggauc      480

aucugcucca ccagcggcgg guuccccgag ccccaccugu ccuggcugga gaacggcgag      540

gagcucaacg cgaucaacac cacggucagc caggacccgg agaccgagcu guacgccgug      600

uccagcaagc uggacuucaa caugaccacc aaccacuccu ucaugugccu caucaaguac      660

gggcaccucc gcgugaacca gacguucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccugc ugcccagcug ggccaucacc cugaucagcg ucaacggcau cuucgugauc      780

ugcugccuga cguacugcuu cgcgccccgg ugccgcgagc ggcgccggaa cgagcgccuc      840

cggcgcgagu ccgugcggcc ggucuga                                          867


<210>  947
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD80__Homo_sapiens__ABK41933

<400>  947
augggccaca cccgccgcca gggcaccucc cccuccaagu gccccuaccu caacuucuuc       60

cagcuccucg uccucgccgg ccucucccac uucugcuccg gcgucaucca cgucaccaag      120

gaggucaagg aggucgccac ccucuccugc ggccacaacg ucuccgucga ggagcucgcc      180

cagacccgca ucuacuggca gaaggagaag aagauggucc ucaccaugau guccggcgac      240

augaacaucu ggcccgagua caagaaccgc accaucuucg acaucaccaa caaccucucc      300

aucgucaucc ucgcccuccg ccccuccgac gagggcaccu acgagugcgu cguccucaag      360

uacgagaagg acgccuucaa gcgcgagcac cucgccgagg ucacccucuc cgucaaggcc      420

gacuucccca cccccuccau cuccgacuuc gagaucccca ccuccaacau ccgccgcauc      480

aucugcucca ccuccggcgg cuuccccgag ccccaccucu ccuggcucga gaacggcgag      540

gagcucaacg ccaucaacac caccgucucc caggaccccg agaccgagcu cuacgccguc      600

uccuccaagc ucgacuucaa caugaccacc aaccacuccu ucaugugccu caucaaguac      660

ggccaccucc gcgucaacca gaccuucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccucc uccccuccug ggccaucacc cucaucuccg ucaacggcau cuucgucauc      780

ugcugccuca ccuacugcuu cgccccccgc ugccgcgagc gccgccgcaa cgagcgccuc      840

cgccgcgagu ccguccgccc cgucuga                                          867


<210>  948
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD80__Homo_sapiens__ABK41933

<400>  948
augggccaca ccagaaggca ggggacaagc cccuccaagu gcccuuaccu gaacuucuuu       60

caacuccuug ugcuggccgg auugucucau uucuguucag gugucaucca cguuacuaaa      120

gaggugaagg aaguagcuac guuaaguugc ggccauaaug ugagcgucga ggaacuggca      180

cagacccgga uuuauuggca gaaagagaag aaaauggugc uaacaaugau guccggggac      240

augaacauau ggccagaaua caagaaucgc acuaucuuug auauuaccaa caaucucucu      300

aucguuauuc uggcccuucg accgucggac gagggaacau augagugugu gguccugaag      360

uacgaaaaag augcguucaa gcgugagcac uuggcugaag ugacccucuc aguaaaagcc      420

gacuuuccca cuccuagcau cagugauuuc gagauaccaa cauccaacau cagaaggauu      480

aucugcucua ccagcggcgg uuuucccgag ccucaucugu ccuggcugga aaauggggag      540

gaacucaacg caauuaauac gacuguuuca caggacccag agaccgaauu auaugccgug      600

aguagcaagc uggauuucaa caugacaacu aaucacucuu uuaugugucu uaucaaauac      660

ggacacuugc gggucaacca aaccuucaau uggaacacaa ccaagcagga gcauuuuccc      720

gacaaucugc uaccuuccug ggcuauaacg cucauuucag ugaacggcau cuucgugauu      780

ugcugucuga cuuauugcuu ugcaccacgc uguagagaga ggcggcgcaa cgaacgacuu      840

agaagggaga gcguccggcc gguuuga                                          867


<210>  949
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD80__Homo_sapiens__ABK41933

<400>  949
augggccaca ccagaagaca gggcaccagc cccagcaagu gccccuaccu gaacuucuuc       60

cagcugcugg ugcuggccgg ccugagccac uucugcagcg gcgugaucca cgugaccaag      120

gaggugaagg agguggccac ccugagcugc ggccacaacg ugagcgugga ggagcuggcc      180

cagaccagaa ucuacuggca gaaggagaag aagauggugc ugaccaugau gagcggcgac      240

augaacaucu ggcccgagua caagaacaga accaucuucg acaucaccaa caaccugagc      300

aucgugaucc uggcccugag acccagcgac gagggcaccu acgagugcgu ggugcugaag      360

uacgagaagg acgccuucaa gagagagcac cuggccgagg ugacccugag cgugaaggcc      420

gacuucccca cccccagcau cagcgacuuc gagaucccca ccagcaacau cagaagaauc      480

aucugcagca ccagcggcgg cuuccccgag ccccaccuga gcuggcugga gaacggcgag      540

gagcugaacg ccaucaacac caccgugagc caggaccccg agaccgagcu guacgccgug      600

agcagcaagc uggacuucaa caugaccacc aaccacagcu ucaugugccu gaucaaguac      660

ggccaccuga gagugaacca gaccuucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccugc ugcccagcug ggccaucacc cugaucagcg ugaacggcau cuucgugauc      780

ugcugccuga ccuacugcuu cgcccccaga ugcagagaga gaagaagaaa cgagagacug      840

agaagagaga gcgugagacc cguguga                                          867


<210>  950
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD80__Homo_sapiens__ABK41933

<400>  950
augggccaca ccagacggca ggggacaagc cccuccaagu gcccuuaccu gaacuucuuu       60

caacuccugg ugcuugccgg acugucucau uucuguagcg gcgucaucca cguuacgaaa      120

gaggugaagg aaguggcuac ccucuccugc gggcauaaug ucucugugga ggaacuggcc      180

cagacacgca uuuauuggca gaaagagaag aaaaugguuc uuaccaugau gagcggagac      240

augaacaucu ggccggaaua caagaauaga acaauuuuug auaucaccaa caaucugucc      300

auugugaucc ucgcgcugcg gcccucugac gagggcacau augagugugu cgugcugaag      360

uacgaaaaag augcuuucaa gcgcgagcac cucgccgaag uuacccugag cgugaaagcc      420

gacuuuccua cgcccuccau cagcgauuuc gagauuccua ccucuaacau cagacggauu      480

aucugcucca caagcggggg auuucccgag ccucaucuuu cuuggcugga aaauggcgag      540

gaacucaacg cuauuaauac cacagucucc caggacccgg agaccgaacu guaugccgug      600

agcucuaaac uugauuucaa caugacgaca aaucacuccu uuaugugucu gaucaaguac      660

ggccaccucc gcgugaacca aaccuucaau uggaacacaa ccaagcagga gcauuuuccc      720

gacaaucugc ugccuagcug ggcuauuacc cucaucuccg ucaacgggau cuucguuauu      780

ugcugucuga cauauugcuu ugcccccaga ugucgggagc gcagacggaa cgaacgccuu      840

agacgggagu cugugcgccc uguguga                                          867


<210>  951
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD80__Homo_sapiens__P33681

<400>  951

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             






<210>  952
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD80__Homo_sapiens__AAA36045

<400>  952
augggccaca cacggaggca gggaacauca ccauccaagu guccauaccu caauuucuuu       60

cagcucuugg ugcuggcugg ucuuucucac uucuguucag guguuaucca cgugaccaag      120

gaagugaaag aaguggcaac gcuguccugu ggucacaaug uuucuguuga agagcuggca      180

caaacucgca ucuacuggca aaaggagaag aaaauggugc ugacuaugau gucuggggac      240

augaauauau ggcccgagua caagaaccgg accaucuuug auaucacuaa uaaccucucc      300

auugugaucc uggcucugcg cccaucugac gagggcacau acgagugugu uguucugaag      360

uaugaaaaag acgcuuucaa gcgggaacac cuggcugaag ugacguuauc agucaaagcu      420

gacuucccua caccuaguau aucugacuuu gaaauuccaa cuucuaauau uagaaggaua      480

auuugcucaa ccucuggagg uuuuccagag ccucaccucu ccugguugga aaauggagaa      540

gaauuaaaug ccaucaacac aacaguuucc caagauccug aaacugagcu cuaugcuguu      600

agcagcaaac uggauuucaa uaugacaacc aaccacagcu ucaugugucu caucaaguau      660

ggacauuuaa gagugaauca gaccuucaac uggaauacaa ccaagcaaga gcauuuuccu      720

gauaaccugc ucccauccug ggccauuacc uuaaucucag uaaauggaau uuuugugaua      780

ugcugccuga ccuacugcuu ugccccaaga ugcagagaga gaaggaggaa ugagagauug      840

agaagggaaa guguacgccc uguauaa                                          867


<210>  953
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD80__Homo_sapiens__AAA36045

<400>  953
augggccaca cccgccggca ggggaccagc cccuccaagu gcccguaccu gaacuucuuc       60

cagcuccugg ugcuggccgg ccucagccac uucugcuccg gggucaucca cgugacgaag      120

gaggugaagg aggucgccac ccugagcugc ggccacaacg uguccgugga ggagcuggcc      180

cagacccgca ucuacuggca gaaggagaag aagauggucc ucaccaugau gagcggggac      240

augaacaucu ggcccgagua caagaaccgg acgaucuucg acaucaccaa caaccugucc      300

aucgugaucc uggcccuccg ccccagcgac gagggcaccu acgagugcgu gguccugaag      360

uacgagaagg acgccuucaa gcgggagcac cuggccgagg ugacccucuc cgugaaggcc      420

gacuucccca cgccgagcau cuccgacuuc gagaucccca ccagcaacau ccgccggauc      480

aucugcucca ccagcggcgg guuccccgag ccccaccugu ccuggcugga gaacggcgag      540

gagcucaacg cgaucaacac cacggucagc caggacccgg agaccgagcu guacgccgug      600

uccagcaagc uggacuucaa caugaccacc aaccacuccu ucaugugccu caucaaguac      660

gggcaccucc gcgugaacca gacguucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccugc ugcccagcug ggccaucacc cugaucagcg ucaacggcau cuucgugauc      780

ugcugccuga cguacugcuu cgcgccccgg ugccgcgagc ggcgccggaa cgagcgccuc      840

cggcgcgagu ccgugcggcc ggucuga                                          867


<210>  954
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD80__Homo_sapiens__AAA36045

<400>  954
augggccaca cccgccgcca gggcaccucc cccuccaagu gccccuaccu caacuucuuc       60

cagcuccucg uccucgccgg ccucucccac uucugcuccg gcgucaucca cgucaccaag      120

gaggucaagg aggucgccac ccucuccugc ggccacaacg ucuccgucga ggagcucgcc      180

cagacccgca ucuacuggca gaaggagaag aagauggucc ucaccaugau guccggcgac      240

augaacaucu ggcccgagua caagaaccgc accaucuucg acaucaccaa caaccucucc      300

aucgucaucc ucgcccuccg ccccuccgac gagggcaccu acgagugcgu cguccucaag      360

uacgagaagg acgccuucaa gcgcgagcac cucgccgagg ucacccucuc cgucaaggcc      420

gacuucccca cccccuccau cuccgacuuc gagaucccca ccuccaacau ccgccgcauc      480

aucugcucca ccuccggcgg cuuccccgag ccccaccucu ccuggcucga gaacggcgag      540

gagcucaacg ccaucaacac caccgucucc caggaccccg agaccgagcu cuacgccguc      600

uccuccaagc ucgacuucaa caugaccacc aaccacuccu ucaugugccu caucaaguac      660

ggccaccucc gcgucaacca gaccuucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccucc uccccuccug ggccaucacc cucaucuccg ucaacggcau cuucgucauc      780

ugcugccuca ccuacugcuu cgccccccgc ugccgcgagc gccgccgcaa cgagcgccuc      840

cgccgcgagu ccguccgccc cgucuga                                          867


<210>  955
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD80__Homo_sapiens__AAA36045

<400>  955
augggccaca ccagaaggca ggggacaagc cccuccaagu gcccuuaccu gaacuucuuu       60

caacuccuug ugcuggccgg auugucucau uucuguucag gugucaucca cguuacuaaa      120

gaggugaagg aaguagcuac guuaaguugc ggccauaaug ugagcgucga ggaacuggca      180

cagacccgga uuuauuggca gaaagagaag aaaauggugc uaacaaugau guccggggac      240

augaacauau ggccagaaua caagaaucgc acuaucuuug auauuaccaa caaucucucu      300

aucguuauuc uggcccuucg accgucggac gagggaacau augagugugu gguccugaag      360

uacgaaaaag augcguucaa gcgugagcac uuggcugaag ugacccucuc aguaaaagcc      420

gacuuuccca cuccuagcau cagugauuuc gagauaccaa cauccaacau cagaaggauu      480

aucugcucua ccagcggcgg uuuucccgag ccucaucugu ccuggcugga aaauggggag      540

gaacucaacg caauuaauac gacuguuuca caggacccag agaccgaauu auaugccgug      600

aguagcaagc uggauuucaa caugacaacu aaucacucuu uuaugugucu uaucaaauac      660

ggacacuugc gggucaacca aaccuucaau uggaacacaa ccaagcagga gcauuuuccc      720

gacaaucugc uaccuuccug ggcuauaacg cucauuucag ugaacggcau cuucgugauu      780

ugcugucuga cuuauugcuu ugcaccacgc uguagagaga ggcggcgcaa cgaacgacuu      840

agaagggaga gcguccggcc gguuuga                                          867


<210>  956
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD80__Homo_sapiens__AAA36045

<400>  956
augggccaca ccagaagaca gggcaccagc cccagcaagu gccccuaccu gaacuucuuc       60

cagcugcugg ugcuggccgg ccugagccac uucugcagcg gcgugaucca cgugaccaag      120

gaggugaagg agguggccac ccugagcugc ggccacaacg ugagcgugga ggagcuggcc      180

cagaccagaa ucuacuggca gaaggagaag aagauggugc ugaccaugau gagcggcgac      240

augaacaucu ggcccgagua caagaacaga accaucuucg acaucaccaa caaccugagc      300

aucgugaucc uggcccugag acccagcgac gagggcaccu acgagugcgu ggugcugaag      360

uacgagaagg acgccuucaa gagagagcac cuggccgagg ugacccugag cgugaaggcc      420

gacuucccca cccccagcau cagcgacuuc gagaucccca ccagcaacau cagaagaauc      480

aucugcagca ccagcggcgg cuuccccgag ccccaccuga gcuggcugga gaacggcgag      540

gagcugaacg ccaucaacac caccgugagc caggaccccg agaccgagcu guacgccgug      600

agcagcaagc uggacuucaa caugaccacc aaccacagcu ucaugugccu gaucaaguac      660

ggccaccuga gagugaacca gaccuucaac uggaacacca ccaagcagga gcacuucccc      720

gacaaccugc ugcccagcug ggccaucacc cugaucagcg ugaacggcau cuucgugauc      780

ugcugccuga ccuacugcuu cgcccccaga ugcagagaga gaagaagaaa cgagagacug      840

agaagagaga gcgugagacc cguguga                                          867


<210>  957
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD80__Homo_sapiens__AAA36045

<400>  957
augggccaca ccagacggca ggggacaagc cccuccaagu gcccuuaccu gaacuucuuu       60

caacuccugg ugcuugccgg acugucucau uucuguagcg gcgucaucca cguuacgaaa      120

gaggugaagg aaguggcuac ccucuccugc gggcauaaug ucucugugga ggaacuggcc      180

cagacacgca uuuauuggca gaaagagaag aaaaugguuc uuaccaugau gagcggagac      240

augaacaucu ggccggaaua caagaauaga acaauuuuug auaucaccaa caaucugucc      300

auugugaucc ucgcgcugcg gcccucugac gagggcacau augagugugu cgugcugaag      360

uacgaaaaag augcuuucaa gcgcgagcac cucgccgaag uuacccugag cgugaaagcc      420

gacuuuccua cgcccuccau cagcgauuuc gagauuccua ccucuaacau cagacggauu      480

aucugcucca caagcggggg auuucccgag ccucaucuuu cuuggcugga aaauggcgag      540

gaacucaacg cuauuaauac cacagucucc caggacccgg agaccgaacu guaugccgug      600

agcucuaaac uugauuucaa caugacgaca aaucacuccu uuaugugucu gaucaaguac      660

ggccaccucc gcgugaacca aaccuucaau uggaacacaa ccaagcagga gcauuuuccc      720

gacaaucugc ugccuagcug ggcuauuacc cucaucuccg ucaacgggau cuucguuauu      780

ugcugucuga cauauugcuu ugcccccaga ugucgggagc gcagacggaa cgaacgccuu      840

agacgggagu cugugcgccc uguguga                                          867


<210>  958
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD86__Homo_sapiens__P42081

<400>  958

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  959
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD86__Homo_sapiens__CCDS3009.1

<400>  959
auggaucccc agugcacuau gggacugagu aacauucucu uugugauggc cuuccugcuc       60

ucuggugcug cuccucugaa gauucaagcu uauuucaaug agacugcaga ccugccaugc      120

caauuugcaa acucucaaaa ccaaagccug agugagcuag uaguauuuug gcaggaccag      180

gaaaacuugg uucugaauga gguauacuua ggcaaagaga aauuugacag uguucauucc      240

aaguauaugg gccgcacaag uuuugauucg gacaguugga cccugagacu ucacaaucuu      300

cagaucaagg acaagggcuu guaucaaugu aucauccauc acaaaaagcc cacaggaaug      360

auucgcaucc accagaugaa uucugaacug ucagugcuug cuaacuucag ucaaccugaa      420

auaguaccaa uuucuaauau aacagaaaau guguacauaa auuugaccug cucaucuaua      480

cacgguuacc cagaaccuaa gaagaugagu guuuugcuaa gaaccaagaa uucaacuauc      540

gaguaugaug guguuaugca gaaaucucaa gauaauguca cagaacugua cgacguuucc      600

aucagcuugu cuguuucauu cccugauguu acgagcaaua ugaccaucuu cuguauucug      660

gaaacugaca agacgcggcu uuuaucuuca ccuuucucua uagagcuuga ggacccucag      720

ccucccccag accacauucc uuggauuaca gcuguacuuc caacaguuau uauaugugug      780

augguuuucu gucuaauucu auggaaaugg aagaagaaga agcggccucg caacucuuau      840

aaauguggaa ccaacacaau ggagagggaa gagagugaac agaccaagaa aagagaaaaa      900

auccauauac cugaaagauc ugaugaagcc cagcguguuu uuaaaaguuc gaagacaucu      960

ucaugcgaca aaagugauac auguuuuuaa                                       990


<210>  960
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD86__Homo_sapiens__CCDS3009.1

<400>  960
auggaccccc agugcaccau gggccugagc aacauccucu ucgugauggc cuuccugcug       60

uccggggccg cgccgcucaa gauccaggcc uacuucaacg agaccgccga ccugcccugc      120

caguucgcca acagccagaa ccagucccug agcgagcucg ucguguucug gcaggaccag      180

gagaaccugg ugcugaacga ggucuaccuc ggcaaggaga aguucgacuc cgugcacagc      240

aaguacaugg ggcgcaccuc cuucgacagc gacuccugga cccugcggcu gcacaaccuc      300

cagaucaagg acaagggccu guaccagugc aucauccacc acaagaagcc caccgggaug      360

auccgcaucc accagaugaa cagcgagcug uccgugcucg ccaacuucag ccagcccgag      420

aucgucccga ucuccaacau caccgagaac guguacauca accugacgug cagcuccauc      480

cacggcuacc ccgagcccaa gaagaugagc gugcugcucc ggaccaagaa cuccaccauc      540

gaguacgacg gcgucaugca gaagucccag gacaacguga ccgagcugua cgacgugagc      600

aucagccuga gcgucuccuu ccccgacgug acgagcaaca ugaccaucuu cugcauccuc      660

gagaccgaca agacccgccu gcuguccagc ccguucucca ucgagcucga ggacccccag      720

cccccgcccg accacauccc cuggaucacg gcggugcugc ccaccgucau caucugcgug      780

augguguucu gccugauccu cuggaagugg aagaagaaga agcggccccg caacagcuac      840

aagugcggga ccaacaccau ggagcgggag gaguccgagc agacgaagaa gcgcgagaag      900

auccacaucc cggagcggag cgacgaggcc cagcgcgucu ucaaguccag caagaccucc      960

agcugcgaca aguccgacac gugcuucuga                                       990


<210>  961
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD86__Homo_sapiens__CCDS3009.1

<400>  961
auggaccccc agugcaccau gggccucucc aacauccucu ucgucauggc cuuccuccuc       60

uccggcgccg ccccccucaa gauccaggcc uacuucaacg agaccgccga ccuccccugc      120

caguucgcca acucccagaa ccagucccuc uccgagcucg ucgucuucug gcaggaccag      180

gagaaccucg uccucaacga ggucuaccuc ggcaaggaga aguucgacuc cguccacucc      240

aaguacaugg gccgcaccuc cuucgacucc gacuccugga cccuccgccu ccacaaccuc      300

cagaucaagg acaagggccu cuaccagugc aucauccacc acaagaagcc caccggcaug      360

auccgcaucc accagaugaa cuccgagcuc uccguccucg ccaacuucuc ccagcccgag      420

aucgucccca ucuccaacau caccgagaac gucuacauca accucaccug cuccuccauc      480

cacggcuacc ccgagcccaa gaagaugucc guccuccucc gcaccaagaa cuccaccauc      540

gaguacgacg gcgucaugca gaagucccag gacaacguca ccgagcucua cgacgucucc      600

aucucccucu ccgucuccuu ccccgacguc accuccaaca ugaccaucuu cugcauccuc      660

gagaccgaca agacccgccu ccucuccucc cccuucucca ucgagcucga ggacccccag      720

cccccccccg accacauccc cuggaucacc gccguccucc ccaccgucau caucugcguc      780

auggucuucu gccucauccu cuggaagugg aagaagaaga agcgcccccg caacuccuac      840

aagugcggca ccaacaccau ggagcgcgag gaguccgagc agaccaagaa gcgcgagaag      900

auccacaucc ccgagcgcuc cgacgaggcc cagcgcgucu ucaaguccuc caagaccucc      960

uccugcgaca aguccgacac cugcuucuga                                       990


<210>  962
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD86__Homo_sapiens__CCDS3009.1

<400>  962
auggaccccc agugcaccau gggccugagc aacauccucu ucgugauggc cuuucuucug       60

uccggggcug caccuuugaa gauucaagcc uacuucaaug agacagcgga uuuaccaugu      120

caguuugcua acucucagaa ucagucacug agugagcuag ucguuuucug gcaagaccag      180

gaaaaccucg ugcugaauga aguauaucuu ggaaaagaga aguuugauag cgugcacucc      240

aaauacaugg guagaacuuc uuucgacucg gauucaugga cgcugagguu gcauaaccuc      300

cagauaaagg acaaaggccu guaucagugc aucauucacc auaagaagcc gaccgggaug      360

auccggauuc accaaaugaa uagcgaacug aguguccucg ccaacuuuuc ccagcccgag      420

aucgugccua uaucuaauau cacagagaac guuuacauua auuuaacuug uagcuccauc      480

cauggauauc cagaacccaa aaagauguca gugcugcuuc gcaccaaaaa caguacaauu      540

gaguacgaug gcgucaugca gaagagucag gacaauguga ccgaauugua ugauguaucu      600

aucucccugu caguuagcuu cccugacgug acuagcaaca ugacaauauu uugcauucua      660

gagaccgaua aaacgcgacu ccugucuucc ccauucagca ucgagcuuga agacccccaa      720

ccuccaccgg aucacauucc cuggaucacu gcaguccugc cuaccgugau cauuugugug      780

auggucuuuu gcuugauacu cuggaagugg aagaaaaaga aacguccaag aaauucguac      840

aaguguggua caaacacuau ggagagggaa gagucugaac agaccaaaaa gcgggagaaa      900

auccacauuc ccgagcgcuc cgacgaagcc cagagaguuu ucaagucaag uaagacaagc      960

uccugcgaca aaucugauac cuguuuuuga                                       990


<210>  963
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD86__Homo_sapiens__CCDS3009.1

<400>  963
auggaccccc agugcaccau gggccugagc aacauccugu ucgugauggc cuuccugcug       60

agcggcgccg ccccccugaa gauccaggcc uacuucaacg agaccgccga ccugcccugc      120

caguucgcca acagccagaa ccagagccug agcgagcugg ugguguucug gcaggaccag      180

gagaaccugg ugcugaacga gguguaccug ggcaaggaga aguucgacag cgugcacagc      240

aaguacaugg gcagaaccag cuucgacagc gacagcugga cccugagacu gcacaaccug      300

cagaucaagg acaagggccu guaccagugc aucauccacc acaagaagcc caccggcaug      360

aucagaaucc accagaugaa cagcgagcug agcgugcugg ccaacuucag ccagcccgag      420

aucgugccca ucagcaacau caccgagaac guguacauca accugaccug cagcagcauc      480

cacggcuacc ccgagcccaa gaagaugagc gugcugcuga gaaccaagaa cagcaccauc      540

gaguacgacg gcgugaugca gaagagccag gacaacguga ccgagcugua cgacgugagc      600

aucagccuga gcgugagcuu ccccgacgug accagcaaca ugaccaucuu cugcauccug      660

gagaccgaca agaccagacu gcugagcagc cccuucagca ucgagcugga ggacccccag      720

cccccccccg accacauccc cuggaucacc gccgugcugc ccaccgugau caucugcgug      780

augguguucu gccugauccu guggaagugg aagaagaaga agagacccag aaacagcuac      840

aagugcggca ccaacaccau ggagagagag gagagcgagc agaccaagaa gagagagaag      900

auccacaucc ccgagagaag cgacgaggcc cagagagugu ucaagagcag caagaccagc      960

agcugcgaca agagcgacac cugcuucuga                                       990


<210>  964
<211>  990
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD86__Homo_sapiens__CCDS3009.1

<400>  964
auggaccccc agugcaccau gggccugagc aacauccucu ucgugauggc cuuucugcuu       60

uccggggcug ccccucugaa gauucaagcg uacuucaaug agacagcuga ucucccgugu      120

caguuugcca acucucagaa ucagagccug uccgaacuug ucguuuucug gcaagaccag      180

gagaaccugg ugcucaauga aguguaucug ggaaaagaga aguuugauuc uguccacagc      240

aaauacaugg gcagaacguc cuucgacucu gauagcugga cccugcggcu ccauaaccug      300

cagaucaagg acaaagggcu uuaucagugc auuauccacc auaagaagcc cacaggaaug      360

auucgcaucc accaaaugaa cuccgaacug agcgugcucg ccaauuuuuc ucagccugag      420

aucguuccca uuuccaauau caccgagaac guguacauua aucugacaug uagcucuauc      480

cauggcuauc cugaacccaa aaagaugucc guccuucuga gaaccaaaaa cagcacaauu      540

gaguacgaug gggugaugca gaagucucag gacaauguua ccgaacucua ugaugugucc      600

aucagccugu ccgucucuuu cccugacgug acgagcaaca ugaccaucuu uugcauucug      660

gagacagaua aaacccggcu ccuguccagc ccguucucua ucgagcuuga agacccccaa      720

ccucccccug aucacauucc cuggaucaca gcugugcugc cgaccgucau uaucuguguu      780

augguguuuu gccucauucu guggaagugg aagaaaaaga aacgcccuag aaauuccuac      840

aaguguggaa cgaacacaau ggagcgggaa gagagcgaac agaccaaaaa gcgcgagaaa      900

auccacaucc ccgagagauc ugacgaagcc cagcgggugu ucaagagcuc caagacaucu      960

agcugcgaca aauccgauac cuguuuuuga                                       990


<210>  965
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD8A__Homo_sapiens__P01732

<400>  965

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  966
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD8A__Homo_sapiens__AAA59674

<400>  966
auggccuuac cagugaccgc cuugcuccug ccgcuggccu ugcugcucca cgccgccagg       60

ccgagccagu uccggguguc gccgcuggau cggaccugga accugggcga gacaguggag      120

cugaagugcc aggugcugcu guccaacccg acgucgggcu gcucguggcu cuuccagccg      180

cgcggcgccg ccgccagucc caccuuccuc cuauaccucu cccaaaacaa gcccaaggcg      240

gccgaggggc uggacaccca gcgguucucg ggcaagaggu ugggggacac cuucguccuc      300

acccugagcg acuuccgccg agagaacgag ggcuacuauu ucugcucggc ccugagcaac      360

uccaucaugu acuucagcca cuucgugccg gucuuccugc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accaucgcgu cgcagccccu gucccugcgc      480

ccagaggcgu gccggccagc ggcggggggc gcagugcaca cgagggggcu ggacuucgcc      540

ugugauaucu acaucugggc gccccuggcc gggacuugug ggguccuucu ccugucacug      600

guuaucaccc uuuacugcaa ccacaggaac cgaagacgug uuugcaaaug uccccggccu      660

guggucaaau cgggagacaa gcccagccuu ucggcgagau acgucuaa                   708


<210>  967
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD8A__Homo_sapiens__AAA59674

<400>  967
auggcccugc ccgugaccgc ccuccugcug ccgcucgcgc ugcugcucca cgccgcccgc       60

cccagccagu uccgggucag cccccuggac cgcaccugga accugggcga gacgguggag      120

cucaagugcc aggugcugcu gagcaacccc accuccgggu gcagcuggcu guuccagccg      180

cggggcgccg ccgcgucccc caccuuccuc cuguaccuca gccagaacaa gcccaaggcc      240

gccgaggggc uggacaccca gcgcuucucc ggcaagcggc ugggggacac guucguccuc      300

acccugagcg acuuccgccg ggagaacgag ggcuacuacu ucugcuccgc ccugagcaac      360

uccaucaugu acuucagcca cuucgugccc guguuccucc cggcgaagcc caccaccacg      420

cccgcgcccc gcccgcccac ccccgccccc accaucgccu cccagccgcu gagccugcgg      480

cccgaggccu gccgccccgc cgccggcggg gccguccaca cccggggccu cgacuucgcc      540

ugcgacaucu acaucugggc gccccuggcc gggacgugcg gcgugcugcu ccugucccug      600

gugaucaccc ucuacugcaa ccaccgcaac cggcgccggg ucugcaagug cccgcgcccc      660

guggugaagu ccggggacaa gcccucccug agcgcccggu acgucuga                   708


<210>  968
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD8A__Homo_sapiens__AAA59674

<400>  968
auggcccucc ccgucaccgc ccuccuccuc ccccucgccc uccuccucca cgccgcccgc       60

cccucccagu uccgcgucuc cccccucgac cgcaccugga accucggcga gaccgucgag      120

cucaagugcc agguccuccu cuccaacccc accuccggcu gcuccuggcu cuuccagccc      180

cgcggcgccg ccgccucccc caccuuccuc cucuaccucu cccagaacaa gcccaaggcc      240

gccgagggcc ucgacaccca gcgcuucucc ggcaagcgcc ucggcgacac cuucguccuc      300

acccucuccg acuuccgccg cgagaacgag ggcuacuacu ucugcuccgc ccucuccaac      360

uccaucaugu acuucuccca cuucgucccc gucuuccucc ccgccaagcc caccaccacc      420

cccgcccccc gcccccccac ccccgccccc accaucgccu cccagccccu cucccuccgc      480

cccgaggccu gccgccccgc cgccggcggc gccguccaca cccgcggccu cgacuucgcc      540

ugcgacaucu acaucugggc cccccucgcc ggcaccugcg gcguccuccu ccucucccuc      600

gucaucaccc ucuacugcaa ccaccgcaac cgccgccgcg ucugcaagug cccccgcccc      660

gucgucaagu ccggcgacaa gcccucccuc uccgcccgcu acgucuga                   708


<210>  969
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD8A__Homo_sapiens__AAA59674

<400>  969
auggcccugc ccgugaccgc ucuccuucug ccuuuggcau uacugcuaca cgccgcgaga       60

ccaagccagu ucagggucuc cccgcucgac cggacaugga accugggcga gacuguugaa      120

cuuaagugcc aagugcuguu gucuaauccc acgucagggu guaguuggcu cuuucagccu      180

cgcggagcug ccgcaagccc aaccuuccug cuguaccucu cccagaacaa acccaaggcc      240

gcugaggguu uagauacaca gcgauuuucu ggcaaacguc ugggggacac uuucguacuu      300

accuugucgg auuuuagaag ggaaaaugag ggauauuacu ucugcucagc acugagcaac      360

aguaucaugu auuuuuccca uuucgugccu gucuuucuac cagccaagcc cacaaccacu      420

ccugcuccac ggccgcccac cccugcccca acaauugcgu cucaaccccu cagccugcgc      480

ccugaagcau guagaccagc cgcuggcggu gccgugcaca cgagggggcu ugacuucgca      540

ugcgauauau acaucugggc uccccuggcc ggaacuugug gcguuuugcu ccuguccuua      600

gugauuaccc uguauugcaa ucaucggaac cgccgaagag ucuguaaaug cccgaggccu      660

gugguaaagu caggcgacaa gcccagucuc agcgcgcggu acguuuga                   708


<210>  970
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD8A__Homo_sapiens__AAA59674

<400>  970
auggcccugc ccgugaccgc ccugcugcug ccccuggccc ugcugcugca cgccgccaga       60

cccagccagu ucagagugag cccccuggac agaaccugga accugggcga gaccguggag      120

cugaagugcc aggugcugcu gagcaacccc accagcggcu gcagcuggcu guuccagccc      180

agaggcgccg ccgccagccc caccuuccug cuguaccuga gccagaacaa gcccaaggcc      240

gccgagggcc uggacaccca gagauucagc ggcaagagac ugggcgacac cuucgugcug      300

acccugagcg acuucagaag agagaacgag ggcuacuacu ucugcagcgc ccugagcaac      360

agcaucaugu acuucagcca cuucgugccc guguuccugc ccgccaagcc caccaccacc      420

cccgccccca gaccccccac ccccgccccc accaucgcca gccagccccu gagccugaga      480

cccgaggccu gcagacccgc cgccggcggc gccgugcaca ccagaggccu ggacuucgcc      540

ugcgacaucu acaucugggc cccccuggcc ggcaccugcg gcgugcugcu gcugagccug      600

gugaucaccc uguacugcaa ccacagaaac agaagaagag ugugcaagug ccccagaccc      660

guggugaaga gcggcgacaa gcccagccug agcgccagau acguguga                   708


<210>  971
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD8A__Homo_sapiens__AAA59674

<400>  971
auggcccugc ccgugaccgc ucuccugcuu ccucuggccc uccugcuuca cgcggcuaga       60

ccgagccagu uccgggucuc uccccuggac cgcacaugga accucggcga gacgguugaa      120

cugaagugcc aagugcugcu cuccaauccu accagcgggu guuccuggcu guuucagccc      180

agaggagccg ccgcuucucc uacauuccuu cuguaccuca gccagaacaa acccaaggcc      240

gcugagggcc uggauaccca gcgguuuucc gggaaacgcc uuggagacac auucgugcug      300

acccucucug auuuuagacg ggaaaaugag ggcuauuacu ucugcagcgc ccuguccaac      360

agcaucaugu auuuuucuca uuucgucccu guguuucugc cggcgaagcc cacaaccacg      420

ccugcgcccc gcccucccac cccggcuccu acaauugccu cccaaccccu cagccugaga      480

ccugaagccu gucggcccgc cgccggggga gccguucaca cccgcggccu ugacuucgcu      540

ugcgauaucu acauuugggc uccccuggcu ggcacaugug gggugcuccu gcuuucucug      600

gucaucaccc ucuauugcaa ucauagaaac cggcgcagag uguguaaaug cccucggccg      660

guugugaagu ccggagacaa gcccagccug ucugcccgcu acgucuga                   708


<210>  972
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDC27/m__Homo_sapiens__G5EA36

<400>  972

Met Thr Val Leu Gln Glu Pro Val Gln Ala Ala Ile Trp Gln Ala Leu 
1               5                   10                  15      


Asn His Tyr Ala Tyr Arg Asp Ala Val Phe Leu Ala Glu Arg Leu Tyr 
            20                  25                  30          


Ala Glu Val His Ser Glu Glu Ala Leu Phe Leu Leu Ala Thr Cys Tyr 
        35                  40                  45              


Tyr Arg Ser Gly Lys Ala Tyr Lys Ala Tyr Arg Leu Leu Lys Gly His 
    50                  55                  60                  


Ser Cys Thr Thr Pro Gln Cys Lys Tyr Leu Leu Ala Lys Cys Cys Val 
65                  70                  75                  80  


Asp Leu Ser Lys Leu Ala Glu Gly Glu Gln Ile Leu Ser Gly Gly Val 
                85                  90                  95      


Phe Asn Lys Gln Lys Ser His Asp Asp Ile Val Thr Glu Phe Gly Asp 
            100                 105                 110         


Ser Ala Cys Phe Thr Leu Ser Leu Leu Gly His Val Tyr Cys Lys Thr 
        115                 120                 125             


Asp Arg Leu Ala Lys Gly Ser Glu Cys Tyr Gln Lys Ser Leu Ser Leu 
    130                 135                 140                 


Asn Pro Phe Leu Trp Ser Pro Phe Glu Ser Leu Cys Glu Ile Gly Glu 
145                 150                 155                 160 


Lys Pro Asp Pro Asp Gln Thr Phe Lys Phe Thr Ser Leu Gln Asn Phe 
                165                 170                 175     


Ser Asn Cys Leu Pro Asn Ser Cys Thr Thr Gln Val Pro Asn His Ser 
            180                 185                 190         


Leu Ser His Arg Gln Pro Glu Thr Val Leu Thr Glu Thr Pro Gln Asp 
        195                 200                 205             


Thr Ile Glu Leu Asn Arg Leu Asn Leu Glu Ser Ser Asn Ser Lys Tyr 
    210                 215                 220                 


Ser Leu Asn Thr Asp Ser Ser Val Ser Tyr Ile Asp Ser Ala Val Ile 
225                 230                 235                 240 


Ser Pro Asp Thr Val Pro Leu Gly Thr Gly Thr Ser Ile Leu Ser Lys 
                245                 250                 255     


Gln Val Gln Asn Lys Pro Lys Thr Gly Arg Ser Leu Leu Gly Gly Pro 
            260                 265                 270         


Ala Ala Leu Ser Pro Leu Thr Pro Ser Phe Gly Ile Leu Pro Leu Glu 
        275                 280                 285             


Thr Pro Ser Pro Gly Asp Gly Ser Tyr Leu Gln Asn Tyr Thr Asn Thr 
    290                 295                 300                 


Pro Pro Val Ile Asp Val Pro Ser Thr Gly Ala Pro Ser Lys Lys Ser 
305                 310                 315                 320 


Val Ala Arg Ile Gly Gln Thr Gly Thr Lys Ser Val Phe Ser Gln Ser 
                325                 330                 335     


Gly Asn Ser Arg Glu Val Thr Pro Ile Leu Ala Gln Thr Gln Ser Ser 
            340                 345                 350         


Gly Pro Gln Thr Ser Thr Thr Pro Gln Val Leu Ser Pro Thr Ile Thr 
        355                 360                 365             


Ser Pro Pro Asn Ala Leu Pro Arg Arg Ser Ser Arg Leu Phe Thr Ser 
    370                 375                 380                 


Asp Ser Ser Thr Thr Lys Glu Asn Ser Lys Lys Leu Lys Met Lys Phe 
385                 390                 395                 400 


Pro Pro Lys Ile Pro Asn Arg Lys Thr Lys Ser Lys Thr Asn Lys Gly 
                405                 410                 415     


Gly Ile Thr Gln Pro Asn Ile Asn Asp Ser Leu Glu Ile Thr Lys Leu 
            420                 425                 430         


Asp Ser Ser Ile Ile Ser Glu Gly Lys Ile Ser Thr Ile Thr Pro Gln 
        435                 440                 445             


Ile Gln Ala Phe Asn Leu Gln Lys Ala Ala Ala Gly Leu Met Ser Leu 
    450                 455                 460                 


Leu Arg Glu Met Gly Lys Gly Tyr Leu Ala Leu Cys Ser Tyr Asn Cys 
465                 470                 475                 480 


Lys Glu Ala Ile Asn Ile Leu Ser His Leu Pro Ser His His Tyr Asn 
                485                 490                 495     


Thr Gly Trp Val Leu Cys Gln Ile Gly Arg Ala Tyr Phe Glu Leu Ser 
            500                 505                 510         


Glu Tyr Met Gln Ala Glu Arg Ile Phe Ser Glu Val Arg Arg Ile Glu 
        515                 520                 525             


Asn Tyr Arg Val Glu Gly Met Glu Ile Tyr Ser Thr Thr Leu Trp His 
    530                 535                 540                 


Leu Gln Lys Asp Val Ala Leu Ser Val Leu Ser Lys Asp Leu Thr Asp 
545                 550                 555                 560 


Met Asp Lys Asn Ser Pro Glu Ala Trp Cys Ala Ala Gly Asn Cys Phe 
                565                 570                 575     


Ser Leu Gln Arg Glu His Asp Ile Ala Ile Lys Phe Phe Gln Arg Ala 
            580                 585                 590         


Ile Gln Val Asp Pro Asn Tyr Ala Tyr Ala Tyr Thr Leu Leu Gly His 
        595                 600                 605             


Glu Phe Val Leu Thr Glu Glu Leu Asp Lys Ala Leu Ala Cys Phe Arg 
    610                 615                 620                 


Asn Ala Ile Arg Val Asn Pro Arg His Tyr Asn Ala Trp Tyr Gly Leu 
625                 630                 635                 640 


Gly Met Ile Tyr Tyr Lys Gln Glu Lys Phe Ser Leu Ala Glu Met His 
                645                 650                 655     


Phe Gln Lys Ala Leu Asp Ile Asn Pro Gln Ser Ser Val Leu Leu Cys 
            660                 665                 670         


His Ile Gly Val Val Gln His Ala Leu Lys Lys Ser Glu Lys Ala Leu 
        675                 680                 685             


Asp Thr Leu Asn Lys Ala Ile Val Ile Asp Pro Lys Asn Pro Leu Cys 
    690                 695                 700                 


Lys Phe His Arg Ala Ser Val Leu Phe Ala Asn Glu Lys Tyr Lys Ser 
705                 710                 715                 720 


Ala Leu Gln Glu Leu Glu Glu Leu Lys Gln Ile Val Pro Lys Glu Ser 
                725                 730                 735     


Leu Val Tyr Phe Leu Ile Gly Lys Val Tyr Lys Lys Leu Gly Gln Thr 
            740                 745                 750         


His Leu Ala Leu Met Asn Phe Ser Trp Ala Met Asp Leu Asp Pro Lys 
        755                 760                 765             


Gly Ala Asn Asn Gln Ile Lys Glu Ala Ile Asp Lys Arg Tyr Leu Pro 
    770                 775                 780                 


Asp Asp Glu Glu Pro Ile Thr Gln Glu Glu Gln Ile Met Gly Thr Asp 
785                 790                 795                 800 


Glu Ser Gln Glu Ser Ser Met Thr Asp Ala Asp Asp Thr Gln Leu His 
                805                 810                 815     


Ala Ala Glu Ser Asp Glu Phe 
            820             


<210>  973
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDC27/m__Homo_sapiens__EAW57688

<400>  973
augacggugc ugcaggaacc cguccaggcu gcuauauggc aagcacuaaa ccacuaugcu       60

uaccgagaug cgguuuuccu cgcagaacgc cuuuaugcag aaguacacuc agaagaagcc      120

uuguuuuuac uggcaaccug uuauuaccgc ucaggaaagg cauauaaagc auauagacuc      180

uugaaaggac acaguuguac uacaccgcaa ugcaaauacc ugcuugcaaa auguuguguu      240

gaucucagca agcuugcaga aggggaacaa aucuuaucug guggaguguu uaauaagcag      300

aaaagccaug augauauugu uacugaguuu ggugauucag cuugcuuuac ucuuucauug      360

uugggacaug uauauugcaa gacagaucgg cuugccaaag gaucagaaug uuaccaaaag      420

agccuuaguu uaaauccuuu ccucuggucu cccuuugaau cauuauguga aauaggugaa      480

aagccagauc cugaccaaac auuuaaauuc acaucuuuac agaacuuuag caacugucug      540

cccaacucuu gcacaacaca aguaccuaau cauaguuuau cucacagaca gccugagaca      600

guucuuacgg aaacacccca ggacacaauu gaauuaaaca gauugaauuu agaaucuucc      660

aauucaaagu acuccuugaa uacagauucc ucagugucuu auauugauuc agcuguaauu      720

ucaccugaua cugucccacu gggaacagga acuuccauau uaucuaaaca gguucaaaau      780

aaaccaaaaa cuggucgaag uuuauuagga ggaccagcag cucuuagucc auuaacccca      840

aguuuuggga uuuugccauu agaaacccca aguccuggag auggauccua uuuacaaaac      900

uacacuaaua caccuccugu aauugaugug ccauccaccg gagccccuuc aaaaaagucu      960

guugccagaa ucggccaaac uggaacaaag ucugucuucu cacagagugg aaauagccga     1020

gagguaacuc caauucuugc acaaacacaa aguucugguc cacaaacaag uacaacaccu     1080

cagguauuga gccccacuau uacaucuccc ccaaacgcac ugccucgaag aaguucacga     1140

cucuuuacua gugacagcuc cacaaccaag gagaauagca aaaaauuaaa aaugaaguuu     1200

ccaccuaaaa ucccaaacag aaaaacaaaa aguaaaacua auaaaggagg aauaacucaa     1260

ccuaacauaa augauagccu ggaaauuaca aaauuggacu cuuccaucau uucagaaggg     1320

aaaauaucca caaucacacc ucagauucag gccuuuaauc uacaaaaagc agcagcaggu     1380

uugaugagcc uucuucguga aauggggaaa gguuauuuag cuuuguguuc auacaacugc     1440

aaagaagcua uaaauauuuu gagccaucua ccuucucacc acuacaauac ugguugggua     1500

cugugccaaa uuggaagggc cuauuuugaa cuuucagagu acaugcaagc ugaaagaaua     1560

uucucagagg uuagaaggau ugagaauuau agaguugaag gcauggagau cuacucuaca     1620

acacuuuggc aucuucaaaa agauguugcu cuuucaguuc ugucaaaaga cuuaacagac     1680

auggauaaaa auucgccaga ggccuggugu gcugcaggga acuguuucag ucugcaacgg     1740

gaacaugaua uugcaauuaa auucuuccag agagcuaucc aaguugaucc aaauuacgcu     1800

uaugccuaua cucuauuagg gcaugaguuu gucuuaacug aagaauugga caaagcauua     1860

gcuuguuuuc gaaaugcuau cagagucaau ccuagacauu auaaugcaug guaugguuua     1920

ggaaugauuu auuacaagca agaaaaauuc agccuugcag aaaugcauuu ccaaaaagcg     1980

cuugauauca acccucaaag uucaguuuua cuuugccaca uuggaguagu ucaacaugca     2040

cugaaaaaau cagagaaggc uuuggauacc cuaaacaaag ccauugucau ugaucccaag     2100

aacccucuau gcaaauuuca cagagccuca guuuuauuug caaaugaaaa auauaagucu     2160

gcuuuacaag aacuugaaga auugaaacaa auuguuccca aagaaucccu cguuuacuuc     2220

uuaauaggaa agguuuacaa gaaguuaggu caaacgcacc ucgcccugau gaauuucucu     2280

ugggcuaugg auuuagaucc uaaaggagcc aauaaccaga uuaaagaggc aauugauaag     2340

cguuaucuuc cagaugauga ggagccaaua acccaagaag aacagaucau gggaacagau     2400

gaaucccagg agagcagcau gacagaugcg gaugacacac aacuucaugc agcugaaagu     2460

gaugaauuuu aa                                                         2472


<210>  974
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDC27/m__Homo_sapiens__EAW57688

<400>  974
augaccgugc ugcaggagcc cguccaggcc gccaucuggc aggcgcucaa ccacuacgcc       60

uaccgcgacg ccguguuccu ggccgagcgg cuguacgccg aggugcacag cgaggaggcc      120

cucuuccugc uggcgaccug cuacuaccgc uccggcaagg ccuacaaggc cuaccggcuc      180

cugaaggggc acagcugcac gaccccgcag ugcaaguacc ugcucgcgaa gugcugcguc      240

gaccugucca agcuggccga gggcgagcag auccucagcg ggggcguguu caacaagcag      300

aagucccacg acgacaucgu gaccgaguuc ggggacagcg ccugcuucac ccugucccug      360

cucggccacg ucuacugcaa gacggaccgc cuggccaagg gcagcgagug cuaccagaag      420

ucccugagcc ucaaccccuu ccuguggucc cccuucgaga gccugugcga gaucggggag      480

aagcccgacc cggaccagac cuucaaguuc accucccucc agaacuucag caacugccug      540

cccaacuccu gcaccaccca ggugcccaac cacagccugu cccaccggca gcccgagacc      600

gugcucaccg agaccccgca ggacacgauc gagcugaacc gccugaaccu cgagagcucc      660

aacagcaagu acagccugaa caccgacucc agcgucuccu acaucgacag cgccgugauc      720

ucccccgaca ccgugccccu gggcaccggg acgagcaucc ucuccaagca gguccagaac      780

aagcccaaga ccggccggag ccugcucggg ggcccggcgg cccugagccc ccugacgccc      840

uccuucggca uccugccccu cgagaccccg ucccccgggg acggcagcua ccugcagaac      900

uacacgaaca ccccgcccgu gaucgacgug cccuccaccg gggcgcccag caagaagucc      960

gucgcccgca ucggccagac cggcaccaag agcguguucu cccagagcgg gaacucccgg     1020

gaggugacgc ccauccuggc ccagacccag agcagcggcc cccagaccuc cacgaccccg     1080

cagguccuca gccccaccau caccuccccg cccaacgccc ugccccgccg gagcucccgc     1140

cuguucacga gcgacuccag caccaccaag gagaacucca agaagcucaa gaugaaguuc     1200

ccgcccaaga uccccaaccg gaagaccaag agcaagacga acaagggcgg gaucacccag     1260

cccaacauca acgacucccu ggagaucacc aagcuggaca gcuccaucau cagcgagggg     1320

aagaucucca ccaucacgcc ccagauccag gccuucaacc uccagaaggc cgccgccggc     1380

cugaugagcc ugcuccgcga gaugggcaag ggguaccugg cgcugugcuc cuacaacugc     1440

aaggaggcca ucaacauccu gagccaccuc cccagccacc acuacaacac cggcugggug     1500

cugugccaga ucgggcgggc cuacuucgag cuguccgagu acaugcaggc cgagcgcauc     1560

uucagcgagg ugcggcgcau cgagaacuac cgggucgagg gcauggagau cuacuccacc     1620

acccucuggc accuccagaa ggacguggcc cugagcgugc uguccaagga ccugaccgac     1680

auggacaaga acagcccgga ggcguggugc gccgccggga acugcuucuc ccugcagcgc     1740

gagcacgaca ucgccaucaa guucuuccag cgggcgaucc aggucgaccc caacuacgcc     1800

uacgccuaca cgcuccuggg ccacgaguuc gugcugaccg aggagcucga caaggcccug     1860

gccugcuucc gcaacgcgau ccgcgucaac ccccggcacu acaacgccug guacggccug     1920

gggaugaucu acuacaagca ggagaaguuc agccucgccg agaugcacuu ccagaaggcc     1980

cuggacauca acccccaguc cagcgugcug cucugccaca ucggcguggu ccagcacgcc     2040

cugaagaagu ccgagaaggc gcuggacacc cucaacaagg ccaucgugau cgacccgaag     2100

aacccccugu gcaaguucca ccgcgccagc gugcuguucg ccaacgagaa guacaagucc     2160

gcccuccagg agcuggagga gcugaagcag aucgucccca aggagagccu cguguacuuc     2220

cugaucggga agguguacaa gaagcugggc cagacccacc ucgcgcugau gaacuucucc     2280

ugggccaugg accuggaccc caagggggcc aacaaccaga ucaaggaggc caucgacaag     2340

cgguaccucc cggacgacga ggagcccauc acgcaggagg agcagaucau gggcaccgac     2400

gagagccagg aguccagcau gaccgacgcg gacgacaccc agcugcacgc cgccgagucc     2460

gacgaguucu ga                                                         2472


<210>  975
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDC27/m__Homo_sapiens__EAW57688

<400>  975
augaccgucc uccaggagcc cguccaggcc gccaucuggc aggcccucaa ccacuacgcc       60

uaccgcgacg ccgucuuccu cgccgagcgc cucuacgccg agguccacuc cgaggaggcc      120

cucuuccucc ucgccaccug cuacuaccgc uccggcaagg ccuacaaggc cuaccgccuc      180

cucaagggcc acuccugcac caccccccag ugcaaguacc uccucgccaa gugcugcguc      240

gaccucucca agcucgccga gggcgagcag auccucuccg gcggcgucuu caacaagcag      300

aagucccacg acgacaucgu caccgaguuc ggcgacuccg ccugcuucac ccucucccuc      360

cucggccacg ucuacugcaa gaccgaccgc cucgccaagg gcuccgagug cuaccagaag      420

ucccucuccc ucaaccccuu ccucuggucc cccuucgagu cccucugcga gaucggcgag      480

aagcccgacc ccgaccagac cuucaaguuc accucccucc agaacuucuc caacugccuc      540

cccaacuccu gcaccaccca gguccccaac cacucccucu cccaccgcca gcccgagacc      600

guccucaccg agacccccca ggacaccauc gagcucaacc gccucaaccu cgaguccucc      660

aacuccaagu acucccucaa caccgacucc uccgucuccu acaucgacuc cgccgucauc      720

ucccccgaca ccgucccccu cggcaccggc accuccaucc ucuccaagca gguccagaac      780

aagcccaaga ccggccgcuc ccuccucggc ggccccgccg cccucucccc ccucaccccc      840

uccuucggca uccucccccu cgagaccccc ucccccggcg acggcuccua ccuccagaac      900

uacaccaaca ccccccccgu caucgacguc cccuccaccg gcgcccccuc caagaagucc      960

gucgcccgca ucggccagac cggcaccaag uccgucuucu cccaguccgg caacucccgc     1020

gaggucaccc ccauccucgc ccagacccag uccuccggcc cccagaccuc caccaccccc     1080

cagguccucu cccccaccau caccuccccc cccaacgccc ucccccgccg cuccucccgc     1140

cucuucaccu ccgacuccuc caccaccaag gagaacucca agaagcucaa gaugaaguuc     1200

ccccccaaga uccccaaccg caagaccaag uccaagacca acaagggcgg caucacccag     1260

cccaacauca acgacucccu cgagaucacc aagcucgacu ccuccaucau cuccgagggc     1320

aagaucucca ccaucacccc ccagauccag gccuucaacc uccagaaggc cgccgccggc     1380

cucauguccc uccuccgcga gaugggcaag ggcuaccucg cccucugcuc cuacaacugc     1440

aaggaggcca ucaacauccu cucccaccuc cccucccacc acuacaacac cggcuggguc     1500

cucugccaga ucggccgcgc cuacuucgag cucuccgagu acaugcaggc cgagcgcauc     1560

uucuccgagg uccgccgcau cgagaacuac cgcgucgagg gcauggagau cuacuccacc     1620

acccucuggc accuccagaa ggacgucgcc cucuccgucc ucuccaagga ccucaccgac     1680

auggacaaga acucccccga ggccuggugc gccgccggca acugcuucuc ccuccagcgc     1740

gagcacgaca ucgccaucaa guucuuccag cgcgccaucc aggucgaccc caacuacgcc     1800

uacgccuaca cccuccucgg ccacgaguuc guccucaccg aggagcucga caaggcccuc     1860

gccugcuucc gcaacgccau ccgcgucaac ccccgccacu acaacgccug guacggccuc     1920

ggcaugaucu acuacaagca ggagaaguuc ucccucgccg agaugcacuu ccagaaggcc     1980

cucgacauca acccccaguc cuccguccuc cucugccaca ucggcgucgu ccagcacgcc     2040

cucaagaagu ccgagaaggc ccucgacacc cucaacaagg ccaucgucau cgaccccaag     2100

aacccccucu gcaaguucca ccgcgccucc guccucuucg ccaacgagaa guacaagucc     2160

gcccuccagg agcucgagga gcucaagcag aucgucccca aggagucccu cgucuacuuc     2220

cucaucggca aggucuacaa gaagcucggc cagacccacc ucgcccucau gaacuucucc     2280

ugggccaugg accucgaccc caagggcgcc aacaaccaga ucaaggaggc caucgacaag     2340

cgcuaccucc ccgacgacga ggagcccauc acccaggagg agcagaucau gggcaccgac     2400

gagucccagg aguccuccau gaccgacgcc gacgacaccc agcuccacgc cgccgagucc     2460

gacgaguucu ga                                                         2472


<210>  976
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDC27/m__Homo_sapiens__EAW57688

<400>  976
augaccgugc ugcaggagcc cguccaagcc gcuaucuggc aggcacucaa ccacuacgcc       60

uauagagacg cgguuuuccu ugcugaaagg cuguacgccg aggugcauag cgaagaggca      120

uuguuuuuac uggccacaug cuauuaccgg uccggcaagg cuuauaaagc auaccgccua      180

cucaaggggc acucuuguac uacgccucag ugcaaauauc ugcuugccaa guguugcgua      240

gaucugucaa aauuggcuga aggagagcag auucucagug guggcguguu caauaagcaa      300

aagagccaug acgauauagu caccgaguuu ggggacuccg ccuguuucac acugucucug      360

cucggacacg uguacugcaa aacugaucga uuagcgaagg gcucggaaug uuaccagaaa      420

ucacugagcc uuaacccauu uuuguggagu ccguucgagu cccugugcga aaucggugag      480

aagcccgacc cugaucagac cuuuaaauuc acaucucuac agaauuuuag caacugucuc      540

ccaaauuccu gcaccacuca aguucccaac cauucacuga gucaccguca gccugagaca      600

gugcuuaccg aaacgccaca ggacacuauu gagcugaaua gauugaaccu cgaaagcucu      660

aauuccaagu auucacugaa caccgauagc agugucucuu acaucgacuc cgcagugauu      720

agccccgaua caguaccuuu agggacugga accucgaucc ugucuaagca gguucaaaau      780

aaaccaaaga caggcagguc ccuccuuggc gggccggccg cucugucacc cuugaccccu      840

aguuucggaa uacuaccacu ggagacgccc agcccuggug acggcuccua ucuccagaac      900

uacacuaaua caccacccgu gaucgauguc ccgucuaccg gggccccuag caaaaaguca      960

guggcacgga uuggacagac uggcacaaaa aguguguuuu cccaaagcgg uaacucucgc     1020

gaagucaccc ccauccuggc ucagacgcag ucaagugggc cacagaccag cacaacuccu     1080

caaguucuuu cccccaccau uacaucucca cccaaugccc ugccuagaag gucgagccgg     1140

uuguucacuu ccgacucaag uaccacaaag gagaacucua aaaagcucaa gaugaaauuu     1200

ccaccgaaga uccccaaccg caaaaccaag agcaaaacua auaagggagg cauaacgcag     1260

ccuaacauua augacucccu ggagaucaca aaguuagauu caagcauuau cucugaaggc     1320

aaaaucucca ccauuacucc acagauacag gcguucaacc ugcaaaaggc cgcagcuggg     1380

cuaaugaguc uccugcgaga gaugggaaaa gguuaucuug ccuuguguag cuacaauugc     1440

aaggaagcua ucaacauucu gucucaccuc cccucccauc acuauaauac cggcugggug     1500

cugugccaga ucgggagagc cuacuucgag cuuucagaau acaugcaggc agagaggaua     1560

uuuagugagg uacggcguau ugaaaacuau cgcguggagg gaauggaaau cuacagcaca     1620

acccuguggc auuugcagaa agacgucgcc cucucggugc uguccaagga uuuaacugac     1680

auggauaaaa auucuccuga ggcuuggugu gcggcaggca acugcuucag ccugcaaaga     1740

gaacacgaca ucgccauuaa guuuuuccag agggcuaucc agguugaucc aaauuaugcc     1800

uacgcauaua cacuacucgg ucacgaguuu gugcugacgg aggaacuuga caaggccuug     1860

gcuuguuucc ggaacgccau ucgagucaau ccccgccauu acaacgcaug guaugggcug     1920

ggcaugauau acuacaaaca ggagaaguuu ucacucgcgg aaaugcacuu ccaaaaagcu     1980

cuggauauca auccgcagag uuccguguua cugugccaua uuggaguagu ucagcacgcc     2040

cuuaagaagu cugagaaagc auuggacacc cucaacaagg ccaucgugau cgauccuaaa     2100

aacccacugu guaaguuuca uagagcuagc guccuauucg ccaaugagaa auauaagucc     2160

gcacugcaag aacucgagga acugaaacag auugugccca aggagucacu ugucuacuuu     2220

uugauaggca agguguauaa aaagcugggg cagacucacu uagcucucau gaacuucagc     2280

ugggccaugg accuggaccc uaaaggagcg aauaaccaga ucaaggaagc cauugauaaa     2340

agguaccuuc ccgacgauga ggagccaauc acacaagagg aacagauuau ggguaccgac     2400

gaaagucagg agucuuccau gacagaugcu gacgauacuc agcugcacgc agccgaaagc     2460

gacgaguuuu ga                                                         2472


<210>  977
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDC27/m__Homo_sapiens__EAW57688

<400>  977
augaccgugc ugcaggagcc cgugcaggcc gccaucuggc aggcccugaa ccacuacgcc       60

uacagagacg ccguguuccu ggccgagaga cuguacgccg aggugcacag cgaggaggcc      120

cuguuccugc uggccaccug cuacuacaga agcggcaagg ccuacaaggc cuacagacug      180

cugaagggcc acagcugcac caccccccag ugcaaguacc ugcuggccaa gugcugcgug      240

gaccugagca agcuggccga gggcgagcag auccugagcg gcggcguguu caacaagcag      300

aagagccacg acgacaucgu gaccgaguuc ggcgacagcg ccugcuucac ccugagccug      360

cugggccacg uguacugcaa gaccgacaga cuggccaagg gcagcgagug cuaccagaag      420

agccugagcc ugaaccccuu ccuguggagc cccuucgaga gccugugcga gaucggcgag      480

aagcccgacc ccgaccagac cuucaaguuc accagccugc agaacuucag caacugccug      540

cccaacagcu gcaccaccca ggugcccaac cacagccuga gccacagaca gcccgagacc      600

gugcugaccg agacccccca ggacaccauc gagcugaaca gacugaaccu ggagagcagc      660

aacagcaagu acagccugaa caccgacagc agcgugagcu acaucgacag cgccgugauc      720

agccccgaca ccgugccccu gggcaccggc accagcaucc ugagcaagca ggugcagaac      780

aagcccaaga ccggcagaag ccugcugggc ggccccgccg cccugagccc ccugaccccc      840

agcuucggca uccugccccu ggagaccccc agccccggcg acggcagcua ccugcagaac      900

uacaccaaca ccccccccgu gaucgacgug cccagcaccg gcgcccccag caagaagagc      960

guggccagaa ucggccagac cggcaccaag agcguguuca gccagagcgg caacagcaga     1020

gaggugaccc ccauccuggc ccagacccag agcagcggcc cccagaccag caccaccccc     1080

caggugcuga gccccaccau caccagcccc cccaacgccc ugcccagaag aagcagcaga     1140

cuguucacca gcgacagcag caccaccaag gagaacagca agaagcugaa gaugaaguuc     1200

ccccccaaga uccccaacag aaagaccaag agcaagacca acaagggcgg caucacccag     1260

cccaacauca acgacagccu ggagaucacc aagcuggaca gcagcaucau cagcgagggc     1320

aagaucagca ccaucacccc ccagauccag gccuucaacc ugcagaaggc cgccgccggc     1380

cugaugagcc ugcugagaga gaugggcaag ggcuaccugg cccugugcag cuacaacugc     1440

aaggaggcca ucaacauccu gagccaccug cccagccacc acuacaacac cggcugggug     1500

cugugccaga ucggcagagc cuacuucgag cugagcgagu acaugcaggc cgagagaauc     1560

uucagcgagg ugagaagaau cgagaacuac agaguggagg gcauggagau cuacagcacc     1620

acccuguggc accugcagaa ggacguggcc cugagcgugc ugagcaagga ccugaccgac     1680

auggacaaga acagccccga ggccuggugc gccgccggca acugcuucag ccugcagaga     1740

gagcacgaca ucgccaucaa guucuuccag agagccaucc agguggaccc caacuacgcc     1800

uacgccuaca cccugcuggg ccacgaguuc gugcugaccg aggagcugga caaggcccug     1860

gccugcuuca gaaacgccau cagagugaac cccagacacu acaacgccug guacggccug     1920

ggcaugaucu acuacaagca ggagaaguuc agccuggccg agaugcacuu ccagaaggcc     1980

cuggacauca acccccagag cagcgugcug cugugccaca ucggcguggu gcagcacgcc     2040

cugaagaaga gcgagaaggc ccuggacacc cugaacaagg ccaucgugau cgaccccaag     2100

aacccccugu gcaaguucca cagagccagc gugcuguucg ccaacgagaa guacaagagc     2160

gcccugcagg agcuggagga gcugaagcag aucgugccca aggagagccu gguguacuuc     2220

cugaucggca agguguacaa gaagcugggc cagacccacc uggcccugau gaacuucagc     2280

ugggccaugg accuggaccc caagggcgcc aacaaccaga ucaaggaggc caucgacaag     2340

agauaccugc ccgacgacga ggagcccauc acccaggagg agcagaucau gggcaccgac     2400

gagagccagg agagcagcau gaccgacgcc gacgacaccc agcugcacgc cgccgagagc     2460

gacgaguucu ga                                                         2472


<210>  978
<211>  2472
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDC27/m__Homo_sapiens__EAW57688

<400>  978
augaccgugc ugcaggagcc cguccaagcc gcuaucuggc aggcccucaa ccacuacgcg       60

uauagagacg cuguuuuccu ggccgaacgg cuuuacgccg aggugcauag cgaagaggcu      120

cuguuucucc uggccacaug cuauuaccgc uccggcaagg cuuauaaagc cuacagacuu      180

cugaaggggc acucuuguac gaccccucag ugcaaauauc uccuggcgaa guguugcgug      240

gaucugagca aacucgccga aggagagcag auucuguccg gcggggucuu caauaagcaa      300

aagucucaug acgauaucgu gacagaguuu ggagacagcg cuuguuucac ccuuucccug      360

cucggccacg uuuacugcaa aacagaucgg cuggccaagg ggucugaaug uuaccagaaa      420

agccuuuccc ugaacccguu ucucuggagc cccuucgagu cucugugcga aauuggagag      480

aagccugacc ccgaucagac cuuuaaauuc acaucccugc agaauuuuag caacugucuc      540

ccuaauucuu gcaccacgca agugcccaac cauucccuga gccaccgcca gccugagacc      600

guccuuacag aaaccccgca ggacacaauc gagcugaaua gacucaaccu ggaaucuucc      660

aauagcaagu auucccuuaa caccgauucu agcguguccu acauugacag cgcuguuauc      720

ucucccgaua cggugccucu gggcacaggc accuccaucc ucagcaagca gguccaaaau      780

aaacccaaga cagggcgguc ucugcuggga ggcccugccg cgcucagccc ccugaccccg      840

uccuucggga uucuuccucu ggagaccccc ucuccuggag acggcagcua ucuccagaac      900

uacacaaaua cgccucccgu gaucgaugug cccuccaccg gggccccgag caaaaagucu      960

gucgcucgca uuggacagac aggcaccaaa uccguuuuua gccaaucugg caacuccaga     1020

gaagugacac ccauccuggc ccagacccag agcuccgggc cucagacguc uacaacaccc     1080

caagugcuua gcccuaccau uaccucuccc ccgaaugcuc ugccucggcg cuccagcaga     1140

cucuucaccu ccgacagcuc uacaacgaag gagaacucca aaaagcugaa gaugaaauuu     1200

cccccuaaga uccccaaccg gaaaaccaag agcaaaacaa auaagggagg cauuacccag     1260

ccuaacauca augacucucu ggagaucaca aagcucgauu ccagcauuau cucugaaggg     1320

aaaauuagca ccaucacgcc ccagauucag gccuucaacc ugcaaaaggc cgcugcggga     1380

cuuauguccc ugcuccgcga gaugggcaaa ggguaucugg cccuguguag cuacaauugc     1440

aaggaagcua ucaacauccu uucucaccuc ccgucccauc acuauaauac cggauggguc     1500

cugugccaga uuggcagagc cuacuucgag cugagcgaau acaugcaggc cgagcggauc     1560

uuuuccgagg ugcgcagaau ugaaaacuau cggguugagg gcauggaaau cuacucuaca     1620

acccucuggc aucugcagaa agacguggcu cuuagcgucc uguccaagga ucucacagac     1680

auggauaaaa auucuccuga ggccuggugu gcggcuggga acugcuucag ccugcaaaga     1740

gaacacgaca uugccaucaa guuuuuccag cgcgccaucc agguggaucc caauuaugcu     1800

uacgccuaua cccugcuugg acacgaguuu guucucacgg aggaacugga caaggcucug     1860

gccuguuucc ggaacgcgau uagagugaau ccccgccauu acaacgccug guauggccuc     1920

gggaugaucu acuacaaaca ggagaaguuu ucccuggcug aaaugcacuu ccaaaaagcc     1980

cuugauauua auccucaguc uagcguccug cucugccaua ucggaguggu ccagcacgcu     2040

cugaagaagu ccgagaaagc ccuggacaca cuuaacaagg cgauugugau cgauccgaaa     2100

aacccccucu guaaguuuca ucgggccagc guucuguucg cuaaugagaa auauaagucu     2160

gcccugcaag aacucgagga acugaaacag auugugccua aggagucccu ugucuacuuu     2220

cugaucggca agguguauaa aaagcucggg cagacccacc uggcucugau gaacuucagc     2280

ugggccaugg accuugaccc caaaggcgcc aauaaccaga ucaaggaagc uauugauaaa     2340

agauaccucc cugacgauga ggagcccauc acacaagagg aacagauuau gggaaccgac     2400

gaaucucagg aguccagcau gaccgaugcg gacgauacac agcugcacgc cgcugaaucu     2460

gacgaguuuu ga                                                         2472


<210>  979
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDC27/m__Homo_sapiens__P30260

<400>  979

Met Thr Val Leu Gln Glu Pro Val Gln Ala Ala Ile Trp Gln Ala Leu 
1               5                   10                  15      


Asn His Tyr Ala Tyr Arg Asp Ala Val Phe Leu Ala Glu Arg Leu Tyr 
            20                  25                  30          


Ala Glu Val His Ser Glu Glu Ala Leu Phe Leu Leu Ala Thr Cys Tyr 
        35                  40                  45              


Tyr Arg Ser Gly Lys Ala Tyr Lys Ala Tyr Arg Leu Leu Lys Gly His 
    50                  55                  60                  


Ser Cys Thr Thr Pro Gln Cys Lys Tyr Leu Leu Ala Lys Cys Cys Val 
65                  70                  75                  80  


Asp Leu Ser Lys Leu Ala Glu Gly Glu Gln Ile Leu Ser Gly Gly Val 
                85                  90                  95      


Phe Asn Lys Gln Lys Ser His Asp Asp Ile Val Thr Glu Phe Gly Asp 
            100                 105                 110         


Ser Ala Cys Phe Thr Leu Ser Leu Leu Gly His Val Tyr Cys Lys Thr 
        115                 120                 125             


Asp Arg Leu Ala Lys Gly Ser Glu Cys Tyr Gln Lys Ser Leu Ser Leu 
    130                 135                 140                 


Asn Pro Phe Leu Trp Ser Pro Phe Glu Ser Leu Cys Glu Ile Gly Glu 
145                 150                 155                 160 


Lys Pro Asp Pro Asp Gln Thr Phe Lys Phe Thr Ser Leu Gln Asn Phe 
                165                 170                 175     


Ser Asn Cys Leu Pro Asn Ser Cys Thr Thr Gln Val Pro Asn His Ser 
            180                 185                 190         


Leu Ser His Arg Gln Pro Glu Thr Val Leu Thr Glu Thr Pro Gln Asp 
        195                 200                 205             


Thr Ile Glu Leu Asn Arg Leu Asn Leu Glu Ser Ser Asn Ser Lys Tyr 
    210                 215                 220                 


Ser Leu Asn Thr Asp Ser Ser Val Ser Tyr Ile Asp Ser Ala Val Ile 
225                 230                 235                 240 


Ser Pro Asp Thr Val Pro Leu Gly Thr Gly Thr Ser Ile Leu Ser Lys 
                245                 250                 255     


Gln Val Gln Asn Lys Pro Lys Thr Gly Arg Ser Leu Leu Gly Gly Pro 
            260                 265                 270         


Ala Ala Leu Ser Pro Leu Thr Pro Ser Phe Gly Ile Leu Pro Leu Glu 
        275                 280                 285             


Thr Pro Ser Pro Gly Asp Gly Ser Tyr Leu Gln Asn Tyr Thr Asn Thr 
    290                 295                 300                 


Pro Pro Val Ile Asp Val Pro Ser Thr Gly Ala Pro Ser Lys Lys Ser 
305                 310                 315                 320 


Val Ala Arg Ile Gly Gln Thr Gly Thr Lys Ser Val Phe Ser Gln Ser 
                325                 330                 335     


Gly Asn Ser Arg Glu Val Thr Pro Ile Leu Ala Gln Thr Gln Ser Ser 
            340                 345                 350         


Gly Pro Gln Thr Ser Thr Thr Pro Gln Val Leu Ser Pro Thr Ile Thr 
        355                 360                 365             


Ser Pro Pro Asn Ala Leu Pro Arg Arg Ser Ser Arg Leu Phe Thr Ser 
    370                 375                 380                 


Asp Ser Ser Thr Thr Lys Glu Asn Ser Lys Lys Leu Lys Met Lys Phe 
385                 390                 395                 400 


Pro Pro Lys Ile Pro Asn Arg Lys Thr Lys Ser Lys Thr Asn Lys Gly 
                405                 410                 415     


Gly Ile Thr Gln Pro Asn Ile Asn Asp Ser Leu Glu Ile Thr Lys Leu 
            420                 425                 430         


Asp Ser Ser Ile Ile Ser Glu Gly Lys Ile Ser Thr Ile Thr Pro Gln 
        435                 440                 445             


Ile Gln Ala Phe Asn Leu Gln Lys Ala Ala Ala Glu Gly Leu Met Ser 
    450                 455                 460                 


Leu Leu Arg Glu Met Gly Lys Gly Tyr Leu Ala Leu Cys Ser Tyr Asn 
465                 470                 475                 480 


Cys Lys Glu Ala Ile Asn Ile Leu Ser His Leu Pro Ser His His Tyr 
                485                 490                 495     


Asn Thr Gly Trp Val Leu Cys Gln Ile Gly Arg Ala Tyr Phe Glu Leu 
            500                 505                 510         


Ser Glu Tyr Met Gln Ala Glu Arg Ile Phe Ser Glu Val Arg Arg Ile 
        515                 520                 525             


Glu Asn Tyr Arg Val Glu Gly Met Glu Ile Tyr Ser Thr Thr Leu Trp 
    530                 535                 540                 


His Leu Gln Lys Asp Val Ala Leu Ser Val Leu Ser Lys Asp Leu Thr 
545                 550                 555                 560 


Asp Met Asp Lys Asn Ser Pro Glu Ala Trp Cys Ala Ala Gly Asn Cys 
                565                 570                 575     


Phe Ser Leu Gln Arg Glu His Asp Ile Ala Ile Lys Phe Phe Gln Arg 
            580                 585                 590         


Ala Ile Gln Val Asp Pro Asn Tyr Ala Tyr Ala Tyr Thr Leu Leu Gly 
        595                 600                 605             


His Glu Phe Val Leu Thr Glu Glu Leu Asp Lys Ala Leu Ala Cys Phe 
    610                 615                 620                 


Arg Asn Ala Ile Arg Val Asn Pro Arg His Tyr Asn Ala Trp Tyr Gly 
625                 630                 635                 640 


Leu Gly Met Ile Tyr Tyr Lys Gln Glu Lys Phe Ser Leu Ala Glu Met 
                645                 650                 655     


His Phe Gln Lys Ala Leu Asp Ile Asn Pro Gln Ser Ser Val Leu Leu 
            660                 665                 670         


Cys His Ile Gly Val Val Gln His Ala Leu Lys Lys Ser Glu Lys Ala 
        675                 680                 685             


Leu Asp Thr Leu Asn Lys Ala Ile Val Ile Asp Pro Lys Asn Pro Leu 
    690                 695                 700                 


Cys Lys Phe His Arg Ala Ser Val Leu Phe Ala Asn Glu Lys Tyr Lys 
705                 710                 715                 720 


Ser Ala Leu Gln Glu Leu Glu Glu Leu Lys Gln Ile Val Pro Lys Glu 
                725                 730                 735     


Ser Leu Val Tyr Phe Leu Ile Gly Lys Val Tyr Lys Lys Leu Gly Gln 
            740                 745                 750         


Thr His Leu Ala Leu Met Asn Phe Ser Trp Ala Met Asp Leu Asp Pro 
        755                 760                 765             


Lys Gly Ala Asn Asn Gln Ile Lys Glu Ala Ile Asp Lys Arg Tyr Leu 
    770                 775                 780                 


Pro Asp Asp Glu Glu Pro Ile Thr Gln Glu Glu Gln Ile Met Gly Thr 
785                 790                 795                 800 


Asp Glu Ser Gln Glu Ser Ser Met Thr Asp Ala Asp Asp Thr Gln Leu 
                805                 810                 815     


His Ala Ala Glu Ser Asp Glu Phe 
            820                 


<210>  980
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDC27/m__Homo_sapiens__AAB34378

<400>  980
augacggugc ugcaggaacc cguccaggcu gcuauauggc aagcacuaaa ccacuaugcu       60

uaccgagaug cgguuuuccu cgcagaacgc cuuuaugcag aaguacacuc agaagaagcc      120

uuguuuuuac uggcaaccug uuauuaccgc ucaggaaagg cauauaaagc auauagacuc      180

uugaaaggac acaguuguac uacaccgcaa ugcaaauacc ugcuugcaaa auguuguguu      240

gaucucagca agcuugcaga aggggaacaa aucuuaucug guggaguguu uaauaagcag      300

aaaagccaug augauauugu uacugaguuu ggugauucag cuugcuuuac ucuuucauug      360

uugggacaug uauauugcaa gacagaucgg cuugccaaag gaucagaaug uuaccaaaag      420

agccuuaguu uaaauccuuu ccucuggucu cccuuugaau cauuauguga aauaggugaa      480

aagccagauc cugaccaaac auuuaaauuc acaucuuuac agaacuuuag caacugucug      540

cccaacucuu gcacaacaca aguaccuaau cauaguuuau cucacagaca gccugagaca      600

guucuuacgg aaacacccca ggacacaauu gaauuaaaca gauugaauuu agaaucuucc      660

aauucaaagu acuccuugaa uacagauucc ucagugucuu auauugauuc agcuguaauu      720

ucaccugaua cugucccacu gggaacagga acuuccauau uaucuaaaca gguucaaaau      780

aaaccaaaaa cuggucgaag uuuauuagga ggaccagcag cucuuagucc auuaacccca      840

aguuuuggga uuuugccauu agaaacccca aguccuggag auggauccua uuuacaaaac      900

uacacuaaua caccuccugu aauugaugug ccauccaccg gagccccuuc aaaaaagucu      960

guugccagaa ucggccaaac uggaacaaag ucugucuucu cacagagugg aaauagccga     1020

gagguaacuc caauucuugc acaaacacaa aguucugguc cacaaacaag uacaacaccu     1080

cagguauuga gccccacuau uacaucuccc ccaaacgcac ugccucgaag aaguucacga     1140

cucuuuacua gugacagcuc cacaaccaag gagaauagca aaaaauuaaa aaugaaguuu     1200

ccaccuaaaa ucccaaacag aaaaacaaaa aguaaaacua auaaaggagg aauaacucaa     1260

ccuaacauaa augauagccu ggaaauuaca aaauuggacu cuuccaucau uucagaaggg     1320

aaaauaucca caaucacacc ucagauucag gccuuuaauc uacaaaaagc agcagcagaa     1380

gguuugauga gccuucuucg ugaaaugggg aaagguuauu uagcuuugug uucauacaac     1440

ugcaaagaag cuauaaauau uuugagccau cuaccuucuc accacuacaa uacugguugg     1500

guacugugcc aaauuggaag ggccuauuuu gaacuuucag aguacaugca agcugaaaga     1560

auauucucag agguuagaag gauugagaau uauagaguug aaggcaugga gaucuacucu     1620

acaacacuuu ggcaucuuca aaaagauguu gcucuuucag uucugucaaa agacuuaaca     1680

gacauggaua aaaauucgcc agaggccugg ugugcugcag ggaacuguuu cagucugcaa     1740

cgggaacaug auauugcaau uaaauucuuc cagagagcua uccaaguuga uccaaauuac     1800

gcuuaugccu auacucuauu agggcaugag uuugucuuaa cugaagaauu ggacaaagca     1860

uuagcuuguu uucgaaaugc uaucagaguc aauccuagac auuauaaugc augguauggu     1920

uuaggaauga uuuauuacaa gcaagaaaaa uucagccuug cagaaaugca uuuccaaaaa     1980

gcgcuugaua ucaacccuca aaguucaguu uuacuuugcc acauuggagu aguucaacau     2040

gcacugaaaa aaucagagaa ggcuuuggau acccuaaaca aagccauugu cauugauccc     2100

aagaacccuc uaugcaaauu ucacagagcc ucaguuuuau uugcaaauga aaaauauaag     2160

ucugcuuuac aagaacuuga agaauugaaa caaauuguuc ccaaagaauc ccucguuuac     2220

uucuuaauag gaaagguuua caagaaguua ggucaaacgc accucgcccu gaugaauuuc     2280

ucuugggcua uggauuuaga uccuaaagga gccaauaacc agauuaaaga ggcaauugau     2340

aagcguuauc uuccagauga ugaggagcca auaacccaag aagaacagau caugggaaca     2400

gaugaauccc aggagagcag caugacagau gcggaugaca cacaacuuca ugcagcugaa     2460

agugaugaau uuuaa                                                      2475


<210>  981
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDC27/m__Homo_sapiens__AAB34378

<400>  981
augaccgugc ugcaggagcc cguccaggcc gccaucuggc aggcgcucaa ccacuacgcc       60

uaccgcgacg ccguguuccu ggccgagcgg cuguacgccg aggugcacag cgaggaggcc      120

cucuuccugc uggcgaccug cuacuaccgc uccggcaagg ccuacaaggc cuaccggcuc      180

cugaaggggc acagcugcac gaccccgcag ugcaaguacc ugcucgcgaa gugcugcguc      240

gaccugucca agcuggccga gggcgagcag auccucagcg ggggcguguu caacaagcag      300

aagucccacg acgacaucgu gaccgaguuc ggggacagcg ccugcuucac ccugucccug      360

cucggccacg ucuacugcaa gacggaccgc cuggccaagg gcagcgagug cuaccagaag      420

ucccugagcc ucaaccccuu ccuguggucc cccuucgaga gccugugcga gaucggggag      480

aagcccgacc cggaccagac cuucaaguuc accucccucc agaacuucag caacugccug      540

cccaacuccu gcaccaccca ggugcccaac cacagccugu cccaccggca gcccgagacc      600

gugcucaccg agaccccgca ggacacgauc gagcugaacc gccugaaccu cgagagcucc      660

aacagcaagu acagccugaa caccgacucc agcgucuccu acaucgacag cgccgugauc      720

ucccccgaca ccgugccccu gggcaccggg acgagcaucc ucuccaagca gguccagaac      780

aagcccaaga ccggccggag ccugcucggg ggcccggcgg cccugagccc ccugacgccc      840

uccuucggca uccugccccu cgagaccccg ucccccgggg acggcagcua ccugcagaac      900

uacacgaaca ccccgcccgu gaucgacgug cccuccaccg gggcgcccag caagaagucc      960

gucgcccgca ucggccagac cggcaccaag agcguguucu cccagagcgg gaacucccgg     1020

gaggugacgc ccauccuggc ccagacccag agcagcggcc cccagaccuc cacgaccccg     1080

cagguccuca gccccaccau caccuccccg cccaacgccc ugccccgccg gagcucccgc     1140

cuguucacga gcgacuccag caccaccaag gagaacucca agaagcucaa gaugaaguuc     1200

ccgcccaaga uccccaaccg gaagaccaag agcaagacga acaagggcgg gaucacccag     1260

cccaacauca acgacucccu ggagaucacc aagcuggaca gcuccaucau cagcgagggg     1320

aagaucucca ccaucacgcc ccagauccag gccuucaacc uccagaaggc cgccgccgag     1380

ggccugauga gccugcuccg cgagaugggc aagggguacc uggcgcugug cuccuacaac     1440

ugcaaggagg ccaucaacau ccugagccac cuccccagcc accacuacaa caccggcugg     1500

gugcugugcc agaucgggcg ggccuacuuc gagcuguccg aguacaugca ggccgagcgc     1560

aucuucagcg aggugcggcg caucgagaac uaccgggucg agggcaugga gaucuacucc     1620

accacccucu ggcaccucca gaaggacgug gcccugagcg ugcuguccaa ggaccugacc     1680

gacauggaca agaacagccc ggaggcgugg ugcgccgccg ggaacugcuu cucccugcag     1740

cgcgagcacg acaucgccau caaguucuuc cagcgggcga uccaggucga ccccaacuac     1800

gccuacgccu acacgcuccu gggccacgag uucgugcuga ccgaggagcu cgacaaggcc     1860

cuggccugcu uccgcaacgc gauccgcguc aacccccggc acuacaacgc cugguacggc     1920

cuggggauga ucuacuacaa gcaggagaag uucagccucg ccgagaugca cuuccagaag     1980

gcccuggaca ucaaccccca guccagcgug cugcucugcc acaucggcgu gguccagcac     2040

gcccugaaga aguccgagaa ggcgcuggac acccucaaca aggccaucgu gaucgacccg     2100

aagaaccccc ugugcaaguu ccaccgcgcc agcgugcugu ucgccaacga gaaguacaag     2160

uccgcccucc aggagcugga ggagcugaag cagaucgucc ccaaggagag ccucguguac     2220

uuccugaucg ggaaggugua caagaagcug ggccagaccc accucgcgcu gaugaacuuc     2280

uccugggcca uggaccugga ccccaagggg gccaacaacc agaucaagga ggccaucgac     2340

aagcgguacc ucccggacga cgaggagccc aucacgcagg aggagcagau caugggcacc     2400

gacgagagcc aggaguccag caugaccgac gcggacgaca cccagcugca cgccgccgag     2460

uccgacgagu ucuga                                                      2475


<210>  982
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDC27/m__Homo_sapiens__AAB34378

<400>  982
augaccgucc uccaggagcc cguccaggcc gccaucuggc aggcccucaa ccacuacgcc       60

uaccgcgacg ccgucuuccu cgccgagcgc cucuacgccg agguccacuc cgaggaggcc      120

cucuuccucc ucgccaccug cuacuaccgc uccggcaagg ccuacaaggc cuaccgccuc      180

cucaagggcc acuccugcac caccccccag ugcaaguacc uccucgccaa gugcugcguc      240

gaccucucca agcucgccga gggcgagcag auccucuccg gcggcgucuu caacaagcag      300

aagucccacg acgacaucgu caccgaguuc ggcgacuccg ccugcuucac ccucucccuc      360

cucggccacg ucuacugcaa gaccgaccgc cucgccaagg gcuccgagug cuaccagaag      420

ucccucuccc ucaaccccuu ccucuggucc cccuucgagu cccucugcga gaucggcgag      480

aagcccgacc ccgaccagac cuucaaguuc accucccucc agaacuucuc caacugccuc      540

cccaacuccu gcaccaccca gguccccaac cacucccucu cccaccgcca gcccgagacc      600

guccucaccg agacccccca ggacaccauc gagcucaacc gccucaaccu cgaguccucc      660

aacuccaagu acucccucaa caccgacucc uccgucuccu acaucgacuc cgccgucauc      720

ucccccgaca ccgucccccu cggcaccggc accuccaucc ucuccaagca gguccagaac      780

aagcccaaga ccggccgcuc ccuccucggc ggccccgccg cccucucccc ccucaccccc      840

uccuucggca uccucccccu cgagaccccc ucccccggcg acggcuccua ccuccagaac      900

uacaccaaca ccccccccgu caucgacguc cccuccaccg gcgcccccuc caagaagucc      960

gucgcccgca ucggccagac cggcaccaag uccgucuucu cccaguccgg caacucccgc     1020

gaggucaccc ccauccucgc ccagacccag uccuccggcc cccagaccuc caccaccccc     1080

cagguccucu cccccaccau caccuccccc cccaacgccc ucccccgccg cuccucccgc     1140

cucuucaccu ccgacuccuc caccaccaag gagaacucca agaagcucaa gaugaaguuc     1200

ccccccaaga uccccaaccg caagaccaag uccaagacca acaagggcgg caucacccag     1260

cccaacauca acgacucccu cgagaucacc aagcucgacu ccuccaucau cuccgagggc     1320

aagaucucca ccaucacccc ccagauccag gccuucaacc uccagaaggc cgccgccgag     1380

ggccucaugu cccuccuccg cgagaugggc aagggcuacc ucgcccucug cuccuacaac     1440

ugcaaggagg ccaucaacau ccucucccac cuccccuccc accacuacaa caccggcugg     1500

guccucugcc agaucggccg cgccuacuuc gagcucuccg aguacaugca ggccgagcgc     1560

aucuucuccg agguccgccg caucgagaac uaccgcgucg agggcaugga gaucuacucc     1620

accacccucu ggcaccucca gaaggacguc gcccucuccg uccucuccaa ggaccucacc     1680

gacauggaca agaacucccc cgaggccugg ugcgccgccg gcaacugcuu cucccuccag     1740

cgcgagcacg acaucgccau caaguucuuc cagcgcgcca uccaggucga ccccaacuac     1800

gccuacgccu acacccuccu cggccacgag uucguccuca ccgaggagcu cgacaaggcc     1860

cucgccugcu uccgcaacgc cauccgcguc aacccccgcc acuacaacgc cugguacggc     1920

cucggcauga ucuacuacaa gcaggagaag uucucccucg ccgagaugca cuuccagaag     1980

gcccucgaca ucaaccccca guccuccguc cuccucugcc acaucggcgu cguccagcac     2040

gcccucaaga aguccgagaa ggcccucgac acccucaaca aggccaucgu caucgacccc     2100

aagaaccccc ucugcaaguu ccaccgcgcc uccguccucu ucgccaacga gaaguacaag     2160

uccgcccucc aggagcucga ggagcucaag cagaucgucc ccaaggaguc ccucgucuac     2220

uuccucaucg gcaaggucua caagaagcuc ggccagaccc accucgcccu caugaacuuc     2280

uccugggcca uggaccucga ccccaagggc gccaacaacc agaucaagga ggccaucgac     2340

aagcgcuacc uccccgacga cgaggagccc aucacccagg aggagcagau caugggcacc     2400

gacgaguccc aggaguccuc caugaccgac gccgacgaca cccagcucca cgccgccgag     2460

uccgacgagu ucuga                                                      2475


<210>  983
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDC27/m__Homo_sapiens__AAB34378

<400>  983
augaccgugc ugcaggagcc cguccaagcc gcuaucuggc aggcacucaa ccacuacgcc       60

uauagagacg cgguuuuccu ugcugaaagg cuguacgccg aggugcauag cgaagaggca      120

uuguuuuuac uggccacaug cuauuaccgg uccggcaagg cuuauaaagc auaccgccua      180

cucaaggggc acucuuguac uacgccucag ugcaaauauc ugcuugccaa guguugcgua      240

gaucugucaa aauuggcuga aggagagcag auucucagug guggcguguu caauaagcaa      300

aagagccaug acgauauagu caccgaguuu ggggacuccg ccuguuucac acugucucug      360

cucggacacg uguacugcaa aacugaucga uuagcgaagg gcucggaaug uuaccagaaa      420

ucacugagcc uuaacccauu uuuguggagu ccguucgagu cccugugcga aaucggugag      480

aagcccgacc cugaucagac cuuuaaauuc acaucucuac agaauuuuag caacugucuc      540

ccaaauuccu gcaccacuca aguucccaac cauucacuga gucaccguca gccugagaca      600

gugcuuaccg aaacgccaca ggacacuauu gagcugaaua gauugaaccu cgaaagcucu      660

aauuccaagu auucacugaa caccgauagc agugucucuu acaucgacuc cgcagugauu      720

agccccgaua caguaccuuu agggacugga accucgaucc ugucuaagca gguucaaaau      780

aaaccaaaga caggcagguc ccuccuuggc gggccggccg cucugucacc cuugaccccu      840

aguuucggaa uacuaccacu ggagacgccc agcccuggug acggcuccua ucuccagaac      900

uacacuaaua caccacccgu gaucgauguc ccgucuaccg gggccccuag caaaaaguca      960

guggcacgga uuggacagac uggcacaaaa aguguguuuu cccaaagcgg uaacucucgc     1020

gaagucaccc ccauccuggc ucagacgcag ucaagugggc cacagaccag cacaacuccu     1080

caaguucuuu cccccaccau uacaucucca cccaaugccc ugccuagaag gucgagccgg     1140

uuguucacuu ccgacucaag uaccacaaag gagaacucua aaaagcucaa gaugaaauuu     1200

ccaccgaaga uccccaaccg caaaaccaag agcaaaacua auaagggagg cauaacgcag     1260

ccuaacauua augacucccu ggagaucaca aaguuagauu caagcauuau cucugaaggc     1320

aaaaucucca ccauuacucc acagauacag gcguucaacc ugcaaaaggc cgcagcugag     1380

gggcuaauga gucuccugcg agaaauggga aaagguuauc uugccuugug uagcuacaau     1440

ugcaaggagg cuaucaacau ucugucucac cuccccuccc aucacuauaa uaccggcugg     1500

gugcugugcc agaucgggag agccuacuuc gaacuuucag aguacaugca ggcagagagg     1560

auauuuagug aaguacggcg uauugagaac uaucgcgugg aaggaaugga gaucuacagc     1620

acaacccugu ggcauuugca gaaagacguc gcccucucgg ugcuguccaa ggauuuaacu     1680

gacauggaua aaaauucucc ugaggcuugg ugugcggcag gcaacugcuu cagccugcaa     1740

agagagcacg acaucgccau uaaguuuuuc cagagggcua uccagguuga uccaaauuau     1800

gccuacgcau auacacuacu cggucacgag uuugugcuga cggaagaacu ugacaaggcc     1860

uuggcuuguu uccggaacgc cauucgaguc aauccccgcc auuacaacgc augguauggg     1920

cugggcauga uauacuacaa acaggaaaag uuuucacucg cggagaugca cuuccaaaaa     1980

gcucuggaua ucaauccgca gaguuccgug uuacugugcc auauuggagu aguucagcac     2040

gcccuuaaga agucugagaa agcauuggac acccucaaca aggccaucgu gaucgauccu     2100

aaaaacccac uguguaaguu ucauagagcu agcguccuau ucgccaauga aaaauauaag     2160

uccgcacugc aagagcucga ggaacugaaa cagauugugc ccaaggaauc acuugucuac     2220

uuuuugauag gcaaggugua uaaaaagcug gggcagacuc acuuagcucu caugaacuuc     2280

agcugggcca uggaccugga cccuaaagga gcgaauaacc agaucaagga ggccauugau     2340

aaaagguacc uucccgacga ugaggaacca aucacacaag aggaacagau uauggguacc     2400

gacgagaguc aggaaucuuc caugacagau gcugacgaua cucagcugca cgcagccgag     2460

agcgacgagu uuuga                                                      2475


<210>  984
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDC27/m__Homo_sapiens__AAB34378

<400>  984
augaccgugc ugcaggagcc cgugcaggcc gccaucuggc aggcccugaa ccacuacgcc       60

uacagagacg ccguguuccu ggccgagaga cuguacgccg aggugcacag cgaggaggcc      120

cuguuccugc uggccaccug cuacuacaga agcggcaagg ccuacaaggc cuacagacug      180

cugaagggcc acagcugcac caccccccag ugcaaguacc ugcuggccaa gugcugcgug      240

gaccugagca agcuggccga gggcgagcag auccugagcg gcggcguguu caacaagcag      300

aagagccacg acgacaucgu gaccgaguuc ggcgacagcg ccugcuucac ccugagccug      360

cugggccacg uguacugcaa gaccgacaga cuggccaagg gcagcgagug cuaccagaag      420

agccugagcc ugaaccccuu ccuguggagc cccuucgaga gccugugcga gaucggcgag      480

aagcccgacc ccgaccagac cuucaaguuc accagccugc agaacuucag caacugccug      540

cccaacagcu gcaccaccca ggugcccaac cacagccuga gccacagaca gcccgagacc      600

gugcugaccg agacccccca ggacaccauc gagcugaaca gacugaaccu ggagagcagc      660

aacagcaagu acagccugaa caccgacagc agcgugagcu acaucgacag cgccgugauc      720

agccccgaca ccgugccccu gggcaccggc accagcaucc ugagcaagca ggugcagaac      780

aagcccaaga ccggcagaag ccugcugggc ggccccgccg cccugagccc ccugaccccc      840

agcuucggca uccugccccu ggagaccccc agccccggcg acggcagcua ccugcagaac      900

uacaccaaca ccccccccgu gaucgacgug cccagcaccg gcgcccccag caagaagagc      960

guggccagaa ucggccagac cggcaccaag agcguguuca gccagagcgg caacagcaga     1020

gaggugaccc ccauccuggc ccagacccag agcagcggcc cccagaccag caccaccccc     1080

caggugcuga gccccaccau caccagcccc cccaacgccc ugcccagaag aagcagcaga     1140

cuguucacca gcgacagcag caccaccaag gagaacagca agaagcugaa gaugaaguuc     1200

ccccccaaga uccccaacag aaagaccaag agcaagacca acaagggcgg caucacccag     1260

cccaacauca acgacagccu ggagaucacc aagcuggaca gcagcaucau cagcgagggc     1320

aagaucagca ccaucacccc ccagauccag gccuucaacc ugcagaaggc cgccgccgag     1380

ggccugauga gccugcugag agagaugggc aagggcuacc uggcccugug cagcuacaac     1440

ugcaaggagg ccaucaacau ccugagccac cugcccagcc accacuacaa caccggcugg     1500

gugcugugcc agaucggcag agccuacuuc gagcugagcg aguacaugca ggccgagaga     1560

aucuucagcg aggugagaag aaucgagaac uacagagugg agggcaugga gaucuacagc     1620

accacccugu ggcaccugca gaaggacgug gcccugagcg ugcugagcaa ggaccugacc     1680

gacauggaca agaacagccc cgaggccugg ugcgccgccg gcaacugcuu cagccugcag     1740

agagagcacg acaucgccau caaguucuuc cagagagcca uccaggugga ccccaacuac     1800

gccuacgccu acacccugcu gggccacgag uucgugcuga ccgaggagcu ggacaaggcc     1860

cuggccugcu ucagaaacgc caucagagug aaccccagac acuacaacgc cugguacggc     1920

cugggcauga ucuacuacaa gcaggagaag uucagccugg ccgagaugca cuuccagaag     1980

gcccuggaca ucaaccccca gagcagcgug cugcugugcc acaucggcgu ggugcagcac     2040

gcccugaaga agagcgagaa ggcccuggac acccugaaca aggccaucgu gaucgacccc     2100

aagaaccccc ugugcaaguu ccacagagcc agcgugcugu ucgccaacga gaaguacaag     2160

agcgcccugc aggagcugga ggagcugaag cagaucgugc ccaaggagag ccugguguac     2220

uuccugaucg gcaaggugua caagaagcug ggccagaccc accuggcccu gaugaacuuc     2280

agcugggcca uggaccugga ccccaagggc gccaacaacc agaucaagga ggccaucgac     2340

aagagauacc ugcccgacga cgaggagccc aucacccagg aggagcagau caugggcacc     2400

gacgagagcc aggagagcag caugaccgac gccgacgaca cccagcugca cgccgccgag     2460

agcgacgagu ucuga                                                      2475


<210>  985
<211>  2475
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDC27/m__Homo_sapiens__AAB34378

<400>  985
augaccgugc ugcaggagcc cguccaagcc gcuaucuggc aggcccucaa ccacuacgcg       60

uauagagacg cuguuuuccu ggccgaacgg cuuuacgccg aggugcauag cgaagaggcu      120

cuguuucucc uggccacaug cuauuaccgc uccggcaagg cuuauaaagc cuacagacuu      180

cugaaggggc acucuuguac gaccccucag ugcaaauauc uccuggcgaa guguugcgug      240

gaucugagca aacucgccga aggagagcag auucuguccg gcggggucuu caauaagcaa      300

aagucucaug acgauaucgu gacagaguuu ggagacagcg cuuguuucac ccuuucccug      360

cucggccacg uuuacugcaa aacagaucgg cuggccaagg ggucugaaug uuaccagaaa      420

agccuuuccc ugaacccguu ucucuggagc cccuucgagu cucugugcga aauuggagag      480

aagccugacc ccgaucagac cuuuaaauuc acaucccugc agaauuuuag caacugucuc      540

ccuaauucuu gcaccacgca agugcccaac cauucccuga gccaccgcca gccugagacc      600

guccuuacag aaaccccgca ggacacaauc gagcugaaua gacucaaccu ggaaucuucc      660

aauagcaagu auucccuuaa caccgauucu agcguguccu acauugacag cgcuguuauc      720

ucucccgaua cggugccucu gggcacaggc accuccaucc ucagcaagca gguccaaaau      780

aaacccaaga cagggcgguc ucugcuggga ggcccugccg cgcucagccc ccugaccccg      840

uccuucggga uucuuccucu ggagaccccc ucuccuggag acggcagcua ucuccagaac      900

uacacaaaua cgccucccgu gaucgaugug cccuccaccg gggccccgag caaaaagucu      960

gucgcucgca uuggacagac aggcaccaaa uccguuuuua gccaaucugg caacuccaga     1020

gaagugacac ccauccuggc ccagacccag agcuccgggc cucagacguc uacaacaccc     1080

caagugcuua gcccuaccau uaccucuccc ccgaaugcuc ugccucggcg cuccagcaga     1140

cucuucaccu ccgacagcuc uacaacgaag gagaacucca aaaagcugaa gaugaaauuu     1200

cccccuaaga uccccaaccg gaaaaccaag agcaaaacaa auaagggagg cauuacccag     1260

ccuaacauca augacucucu ggagaucaca aagcucgauu ccagcauuau cucugaaggg     1320

aaaauuagca ccaucacgcc ccagauucag gccuucaacc ugcaaaaggc cgcugcggag     1380

ggacuuaugu cccugcuccg cgaaaugggc aaaggguauc uggcccugug uagcuacaau     1440

ugcaaggagg cuaucaacau ccuuucucac cucccguccc aucacuauaa uaccggaugg     1500

guccugugcc agauuggcag agccuacuuc gaacugagcg aguacaugca ggccgagcgg     1560

aucuuuuccg aagugcgcag aauugagaac uaucggguug aaggcaugga gaucuacucu     1620

acaacccucu ggcaucugca gaaagacgug gcucuuagcg uccuguccaa ggaucucaca     1680

gacauggaua aaaauucucc ugaagccugg ugugcggcug ggaacugcuu cagccugcaa     1740

agagagcacg acauugccau caaguuuuuc cagcgcgcca uccaggugga ucccaauuau     1800

gcuuacgccu auacccugcu uggacacgag uuuguucuca cggaagaacu ggacaaggcu     1860

cuggccuguu uccggaacgc gauuagagug aauccccgcc auuacaacgc cugguauggc     1920

cucgggauga ucuacuacaa acaggaaaag uuuucccugg cugagaugca cuuccaaaaa     1980

gcccuugaua uuaauccuca gucuagcguc cugcucugcc auaucggagu gguccagcac     2040

gcucugaaga aguccgagaa agcccuggac acacuuaaca aggcgauugu gaucgauccg     2100

aaaaaccccc ucuguaaguu ucaucgggcc agcguucugu ucgcuaauga aaaauauaag     2160

ucugcccugc aagagcucga ggagcugaaa cagauugugc cuaaggaauc ccuugucuac     2220

uuucugaucg gcaaggugua uaaaaagcuc gggcagaccc accuggcucu gaugaacuuc     2280

agcugggcca uggaccuuga ccccaaaggc gccaauaacc agaucaagga ggcuauugau     2340

aaaagauacc ucccugacga ugaggaaccc aucacacaag aggaacagau uaugggaacc     2400

gacgagucuc aggaauccag caugaccgau gcggacgaua cacagcugca cgccgcugag     2460

ucugacgagu uuuga                                                      2475


<210>  986
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDE30__Homo_sapiens__P28908

<400>  986

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  987
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDE30__Homo_sapiens__AAA51947

<400>  987
augcgcgucc uccucgccgc gcugggacug cuguuccugg gggcgcuacg agccuuccca       60

caggaucgac ccuucgagga caccugucau ggaaacccca gccacuacua ugacaaggcu      120

gucaggaggu gcuguuaccg cugccccaug gggcuguucc cgacacagca gugcccacag      180

aggccuacug acugcaggaa gcagugugag ccugacuacu accuggauga ggccgaccgc      240

uguacagccu gcgugacuug uucucgagau gaccucgugg agaagacgcc gugugcaugg      300

aacuccuccc gugucugcga augucgaccc ggcauguucu guuccacguc ugccgucaac      360

uccugugccc gcugcuucuu ccauucuguc uguccggcag ggaugauugu caaguuccca      420

ggcacggcgc agaagaacac ggucugugag ccggcuuccc caggggucag cccugccugu      480

gccagcccag agaacugcaa ggaacccucc aguggcacca ucccccaggc caagcccacc      540

ccgguguccc cagcaaccuc cagugccagc accaugccug uaagaggggg cacccgccuc      600

gcccaggaag cugcuucuaa acugacgagg gcucccgacu cucccuccuc ugugggaagg      660

ccuaguucag auccaggucu guccccaaca cagccaugcc cagagggguc uggugauugc      720

agaaagcagu gugagcccga cuacuaccug gacgaggccg gccgcugcac agccugcgug      780

agcuguucuc gagaugaccu uguggagaag acgccaugug cauggaacuc cucccgcacc      840

ugcgaauguc gaccuggcau gaucugugcc acaucagcca ccaacuccug ugcccgcugu      900

guccccuacc caaucugugc agcagagacg gucaccaagc cccaggauau ggcugagaag      960

gacaccaccu uugaggcgcc accccugggg acccagccgg acugcaaccc caccccagag     1020

aauggcgagg cgccugccag caccagcccc acucagagcu ugcuggugga cucccaggcc     1080

aguaagacgc ugcccauccc aaccagcgcu cccgucgcuc ucuccuccac ggggaagccc     1140

guucuggaug cagggccagu gcucuucugg gugauccugg uguugguugu gguggucggc     1200

uccagcgccu uccuccugug ccaccggagg gccugcagga agcgaauucg gcagaagcuc     1260

caccugugcu acccggucca gaccucccag cccaagcuag agcuugugga uuccagaccc     1320

aggaggagcu caacgcagcu gaggaguggu gcgucgguga cagaacccgu cgcggaagag     1380

cgaggguuaa ugagccagcc acugauggag accugccaca gcgugggggc agccuaccug     1440

gagagccugc cgcugcagga ugccagcccg gccgggggcc ccucgucccc cagggaccuu     1500

ccugagcccc ggguguccac ggagcacacc aauaacaaga uugagaaaau cuacaucaug     1560

aaggcugaca ccgugaucgu ggggaccgug aaggcugagc ugccggaggg ccggggccug     1620

gcggggccag cagagcccga guuggaggag gagcuggagg cggaccauac cccccacuac     1680

cccgagcagg agacagaacc gccucugggc agcugcagcg augucaugcu cucaguggaa     1740

gaggaaggga aagaagaccc cuugcccaca gcugccucug gaaaguga                  1788


<210>  988
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDE30__Homo_sapiens__AAA51947

<400>  988
augcgcgugc ugcucgccgc ccugggccuc cucuuccugg gggcgcugcg ggccuucccc       60

caggaccgcc cguucgagga cacgugccac ggcaacccca gccacuacua cgacaaggcc      120

guccggcgcu gcugcuaccg gugccccaug gggcuguucc ccacccagca gugcccgcag      180

cgccccaccg acugccggaa gcagugcgag cccgacuacu accuggacga ggccgaccgc      240

ugcaccgccu gcgugaccug cucccgggac gaccuggugg agaagacccc cugcgcgugg      300

aacagcuccc gcgucugcga gugccggccg ggcauguucu gcagcaccuc cgccgugaac      360

agcugcgccc gcugcuucuu ccacuccgug ugccccgccg ggaugaucgu caaguucccc      420

ggcaccgcgc agaagaacac cgugugcgag cccgccagcc cgggcguguc ccccgccugc      480

gccagccccg agaacugcaa ggagcccucc agcgggacca ucccgcaggc caagcccacg      540

cccgucuccc ccgcgaccag cuccgccagc accaugccgg ugcggggcgg gacccgccuc      600

gcccaggagg ccgccuccaa gcugacgcgg gcgcccgaca gccccuccag cgugggccgc      660

cccagcuccg acccggggcu gagccccacc cagcccugcc ccgagggcuc cggcgacugc      720

cggaagcagu gcgagccgga cuacuaccuc gacgaggccg ggcgcugcac cgccugcguc      780

agcugcuccc gggacgaccu gguggagaag acccccugcg ccuggaacag cucccgcacg      840

ugcgagugcc ggcccggcau gaucugcgcc accagcgcga ccaacuccug cgcccgcugc      900

gugccguacc ccaucugcgc cgccgagacc gucacgaagc cccaggacau ggccgagaag      960

gacaccaccu ucgaggcgcc cccgcugggg acccagcccg acugcaaccc cacgcccgag     1020

aacggcgagg ccccggccag caccuccccc acccagagcc uccuggugga cucccaggcc     1080

agcaagaccc ugcccauccc cacguccgcg ccgguggccc ucagcuccac cggcaagccc     1140

guccuggacg ccgggcccgu gcuguucugg gugauccucg uccugguggu ggucgugggc     1200

agcuccgccu uccugcucug ccaccgccgg gccugccgca agcggauccg ccagaagcug     1260

caccugugcu accccgucca gaccagccag ccgaagcucg agcuggugga cagccggccc     1320

cgccggucca gcacccagcu gcgcuccggg gcgagcguga cggagcccgu cgccgaggag     1380

cggggccuca ugucccagcc ccugauggag accugccaca gcgugggggc cgccuaccug     1440

gagucccucc cgcugcagga cgccagcccc gcgggcggcc ccuccagccc ccgcgaccug     1500

ccggagcccc ggguguccac cgagcacacc aacaacaaga ucgagaagau cuacaucaug     1560

aaggccgaca cggucaucgu ggggaccgug aaggccgagc uccccgaggg ccgcgggcug     1620

gccggcccgg ccgagcccga gcuggaggag gagcucgagg cggaccacac gccccacuac     1680

cccgagcagg agaccgagcc gccccugggg agcugcuccg acgucaugcu gagcguggag     1740

gaggagggca aggaggaccc ccuccccacc gccgccuccg gcaaguga                  1788


<210>  989
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDE30__Homo_sapiens__AAA51947

<400>  989
augcgcgucc uccucgccgc ccucggccuc cucuuccucg gcgcccuccg cgccuucccc       60

caggaccgcc ccuucgagga caccugccac ggcaaccccu cccacuacua cgacaaggcc      120

guccgccgcu gcugcuaccg cugccccaug ggccucuucc ccacccagca gugcccccag      180

cgccccaccg acugccgcaa gcagugcgag cccgacuacu accucgacga ggccgaccgc      240

ugcaccgccu gcgucaccug cucccgcgac gaccucgucg agaagacccc cugcgccugg      300

aacuccuccc gcgucugcga gugccgcccc ggcauguucu gcuccaccuc cgccgucaac      360

uccugcgccc gcugcuucuu ccacuccguc ugccccgccg gcaugaucgu caaguucccc      420

ggcaccgccc agaagaacac cgucugcgag cccgccuccc ccggcgucuc ccccgccugc      480

gccucccccg agaacugcaa ggagcccucc uccggcacca ucccccaggc caagcccacc      540

cccgucuccc ccgccaccuc cuccgccucc accaugcccg uccgcggcgg cacccgccuc      600

gcccaggagg ccgccuccaa gcucacccgc gcccccgacu cccccuccuc cgucggccgc      660

cccuccuccg accccggccu cucccccacc cagcccugcc ccgagggcuc cggcgacugc      720

cgcaagcagu gcgagcccga cuacuaccuc gacgaggccg gccgcugcac cgccugcguc      780

uccugcuccc gcgacgaccu cgucgagaag acccccugcg ccuggaacuc cucccgcacc      840

ugcgagugcc gccccggcau gaucugcgcc accuccgcca ccaacuccug cgcccgcugc      900

guccccuacc ccaucugcgc cgccgagacc gucaccaagc cccaggacau ggccgagaag      960

gacaccaccu ucgaggcccc cccccucggc acccagcccg acugcaaccc cacccccgag     1020

aacggcgagg cccccgccuc caccuccccc acccaguccc uccucgucga cucccaggcc     1080

uccaagaccc uccccauccc caccuccgcc cccgucgccc ucuccuccac cggcaagccc     1140

guccucgacg ccggccccgu ccucuucugg gucauccucg uccucgucgu cgucgucggc     1200

uccuccgccu uccuccucug ccaccgccgc gccugccgca agcgcauccg ccagaagcuc     1260

caccucugcu accccgucca gaccucccag cccaagcucg agcucgucga cucccgcccc     1320

cgccgcuccu ccacccagcu ccgcuccggc gccuccguca ccgagcccgu cgccgaggag     1380

cgcggccuca ugucccagcc ccucauggag accugccacu ccgucggcgc cgccuaccuc     1440

gagucccucc cccuccagga cgccuccccc gccggcggcc ccuccucccc ccgcgaccuc     1500

cccgagcccc gcgucuccac cgagcacacc aacaacaaga ucgagaagau cuacaucaug     1560

aaggccgaca ccgucaucgu cggcaccguc aaggccgagc uccccgaggg ccgcggccuc     1620

gccggccccg ccgagcccga gcucgaggag gagcucgagg ccgaccacac cccccacuac     1680

cccgagcagg agaccgagcc cccccucggc uccugcuccg acgucaugcu cuccgucgag     1740

gaggagggca aggaggaccc ccuccccacc gccgccuccg gcaaguga                  1788


<210>  990
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDE30__Homo_sapiens__AAA51947

<400>  990
augagagugc ugcucgccgc ucuuggccug uuguucuuag gggcacugag ggccuuuccc       60

caggaccggc cuuucgagga uaccugccac ggaaacccaa gccauuacua ugacaaggcg      120

guccgccgau guugcuaccg uuguccgaug ggucuauuuc ccacacaaca gugcccucag      180

agaccaacug auuguaggaa acagugcgaa cccgacuauu accucgauga ggcugaccgg      240

uguacggccu gcguuaccug uucccgcgau gaccuggugg aaaagacacc uugcgcaugg      300

aacucuucaa gaguauguga gugcaggcca ggcauguucu gcaguacuag cgccgucaau      360

uccugugcuc ggugcuuuuu ccacucugug ugucccgcag ggaugaucgu gaaauuuccu      420

ggaaccgccc aaaagaauac aguuugcgaa ccagcuucgc cgggcguguc acccgccugu      480

gcgagcccug agaacugcaa agagccaagu uccgguacca uuccccaggc aaagccuacu      540

ccagucucuc ccgccacaag cuccgcuuca accaugccgg ugcgcggggg aacgcgacuu      600

gcccaggaag cagcuaguaa gcugacuaga gccccugaua gccccucuuc cguaggcagg      660

ccaucaagcg acccuggcuu gagucccacc cagccauguc ccgagggguc uggagauugc      720

cggaaacaau gugaaccuga cuauuaccuc gaugaggcgg gucguugcac agccuguguu      780

uccugcagcc gcgacgaccu gguggagaag acuccaugcg cauggaacuc gucuagaacc      840

ugugaaugca ggccgggcau gauaugugcu acauccgcca ccaauucaug cgcucggugu      900

guccccuauc cuaucugcgc cgcagagacg gugacuaaac cacaggauau ggccgaaaag      960

gacacaaccu ucgaggcucc cccucugggg acucagccag auuguaaucc cacaccggaa     1020

aacggagagg cgccugcaag uaccagccca acgcaguccc ucuuagugga cucucaagcc     1080

agcaaaaccc ugcccauucc uacaucagcu cccgucgccc uuaguuccac uggcaagcca     1140

guuuuggaug cagguccugu gcuguuuugg guaauccuag ugcucgucgu gguugugggg     1200

agcucugccu uccugcuuug ccaucgacgc gcuuguagaa agaggauucg gcagaaacug     1260

cacuugugcu accccgucca gaccucacaa ccaaagcucg agcuggugga cagucgcccg     1320

agaaggagcu ccacacaguu acguucugga gccucgguaa cugaaccugu ugcagaggaa     1380

cggggccuga ugagccagcc ccucauggag accugucauu ccgugggcgc ggcuuaccuu     1440

gaaucacugc cauugcagga ugccaguccc gcagggggac cuucuagccc acgagaccua     1500

cccgagccua gagucuccac agagcacacc aauaacaaaa ucgaaaagau auauaucaug     1560

aaagccgaua cugugauugu cgguacggug aaggcugagc ugccggaagg cagggggcuc     1620

gccggaccag cagagcccga acuggaggag gaacuugagg cugaccacac accucauuac     1680

ccagaacaag agaccgagcc cccucugggc ucaugcagcg auguuauguu gucuguggaa     1740

gaggaaggua aagaggaccc gcuccccacu gccgcguccg ggaaguga                  1788


<210>  991
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDE30__Homo_sapiens__AAA51947

<400>  991
augagagugc ugcuggccgc ccugggccug cuguuccugg gcgcccugag agccuucccc       60

caggacagac ccuucgagga caccugccac ggcaacccca gccacuacua cgacaaggcc      120

gugagaagau gcugcuacag augccccaug ggccuguucc ccacccagca gugcccccag      180

agacccaccg acugcagaaa gcagugcgag cccgacuacu accuggacga ggccgacaga      240

ugcaccgccu gcgugaccug cagcagagac gaccuggugg agaagacccc cugcgccugg      300

aacagcagca gagugugcga gugcagaccc ggcauguucu gcagcaccag cgccgugaac      360

agcugcgcca gaugcuucuu ccacagcgug ugccccgccg gcaugaucgu gaaguucccc      420

ggcaccgccc agaagaacac cgugugcgag cccgccagcc ccggcgugag ccccgccugc      480

gccagccccg agaacugcaa ggagcccagc agcggcacca ucccccaggc caagcccacc      540

cccgugagcc ccgccaccag cagcgccagc accaugcccg ugagaggcgg caccagacug      600

gcccaggagg ccgccagcaa gcugaccaga gcccccgaca gccccagcag cgugggcaga      660

cccagcagcg accccggccu gagccccacc cagcccugcc ccgagggcag cggcgacugc      720

agaaagcagu gcgagcccga cuacuaccug gacgaggccg gcagaugcac cgccugcgug      780

agcugcagca gagacgaccu gguggagaag acccccugcg ccuggaacag cagcagaacc      840

ugcgagugca gacccggcau gaucugcgcc accagcgcca ccaacagcug cgccagaugc      900

gugcccuacc ccaucugcgc cgccgagacc gugaccaagc cccaggacau ggccgagaag      960

gacaccaccu ucgaggcccc cccccugggc acccagcccg acugcaaccc cacccccgag     1020

aacggcgagg cccccgccag caccagcccc acccagagcc ugcuggugga cagccaggcc     1080

agcaagaccc ugcccauccc caccagcgcc cccguggccc ugagcagcac cggcaagccc     1140

gugcuggacg ccggccccgu gcuguucugg gugauccugg ugcugguggu gguggugggc     1200

agcagcgccu uccugcugug ccacagaaga gccugcagaa agagaaucag acagaagcug     1260

caccugugcu accccgugca gaccagccag cccaagcugg agcuggugga cagcagaccc     1320

agaagaagca gcacccagcu gagaagcggc gccagcguga ccgagcccgu ggccgaggag     1380

agaggccuga ugagccagcc ccugauggag accugccaca gcgugggcgc cgccuaccug     1440

gagagccugc cccugcagga cgccagcccc gccggcggcc ccagcagccc cagagaccug     1500

cccgagccca gagugagcac cgagcacacc aacaacaaga ucgagaagau cuacaucaug     1560

aaggccgaca ccgugaucgu gggcaccgug aaggccgagc ugcccgaggg cagaggccug     1620

gccggccccg ccgagcccga gcuggaggag gagcuggagg ccgaccacac cccccacuac     1680

cccgagcagg agaccgagcc cccccugggc agcugcagcg acgugaugcu gagcguggag     1740

gaggagggca aggaggaccc ccugcccacc gccgccagcg gcaaguga                  1788


<210>  992
<211>  1788
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDE30__Homo_sapiens__AAA51947

<400>  992
augagagugc ugcucgccgc ucugggccuu cuguuccucg gggcccugcg ggcguuuccc       60

caggaccgcc cuuucgagga uaccugccac ggaaacccga gccauuacua ugacaaggcu      120

gucagacggu guugcuaccg cugucccaug ggccuuuuuc cuacacaaca gugcccccag      180

agaccuacgg auugucggaa acagugcgaa cccgacuauu accuggauga ggccgaccgc      240

uguaccgccu gcguuacaug uuccagagau gaccucgugg aaaagacccc uugcgcuugg      300

aacucuagcc ggguguguga gugccgcccg gggauguucu gcuccacauc ugccgucaau      360

agcugugcua gaugcuuuuu ccacuccgug ugucccgccg gaaugaucgu uaaauuuccu      420

ggcaccgcgc aaaagaauac agugugcgaa cccgccucuc cuggggucag ccccgcuugu      480

gccuccccgg agaacugcaa agagccuagc ucuggaacca uuccccaggc uaagccuacg      540

cccguguccc ccgccaccag cucugcgucc acaaugccug uucggggcgg cacccgccug      600

gcccaggaag cugccagcaa gcugacaaga gcuccggauu cucccuccag cguggggcgg      660

ccuuccucug accccggacu cagcccuacc cagcccuguc cggagggcuc cggggauugc      720

cgcaaacaau gugaaccuga cuauuaccug gaugaggccg gaagaugcac ggccuguguc      780

agcugcucuc gggacgaccu uguggagaag acacccugcg cuuggaacuc cagcagaacc      840

ugugaaugcc gcccuggcau gaucugugcg acaucugcca ccaauagcug cgcucggugu      900

gugcccuauc cuauuugcgc cgccgagacc gucacaaaac cccaggauau ggcugaaaag      960

gacacgaccu ucgaggcccc gccucugggg acacagcccg auuguaaucc caccccugaa     1020

aacggagagg cgccggcuuc cacaucuccc acccagagcc uccugguuga cucccaagcc     1080

agcaaaacgc uuccuauccc cacaucugcc ccuguggcuc uguccagcac cggcaagccc     1140

gugcucgaug ccggcccugu ccuguuuugg gugauucugg uucucguggu cgugguuggg     1200

ucuuccgcuu uccugcuuug ccauagacgc gccugucgga agagaauccg ccagaaacug     1260

caccucugcu accccgugca gaccagccaa ccgaagcugg agcuugucga cucccggccu     1320

agacgcucua gcacacagcu gcgguccgga gcgucuguga ccgaacccgu cgccgaggaa     1380

agaggccuca ugagccagcc ucugauggag acaugucauu ccgugggggc ugccuaccug     1440

gaaagccucc cccugcagga ugcuucuccg gccggaggcc cuuccagccc ccgcgaccuu     1500

ccugagcccc ggguuucuac ggagcacacc aauaacaaaa ucgaaaagau uuauaucaug     1560

aaagcggaua cagugauugu cgggaccgug aaggccgagc ugcccgaagg aagaggccuc     1620

gcuggcccug ccgagccgga acuggaggag gaacuugagg cugaccacac accccauuac     1680

ccugaacaag agaccgagcc cccucugggg uccugcagcg auguuaugcu cucuguggaa     1740

gaggaaggaa aagaggaccc ccugccuacg gccgccagcg gcaaguga                  1788


<210>  993
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__A0A024RBB6

<400>  993

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  994
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__EAW97060

<400>  994
auggcuaccu cucgauauga gccaguggcu gaaauuggug ucggugccua ugggacagug       60

uacaaggccc gugaucccca caguggccac uuuguggccc ucaagagugu gagagucccc      120

aauggaggag gagguggagg aggccuuccc aucagcacag uucgugaggu ggcuuuacug      180

aggcgacugg aggcuuuuga gcaucccaau guuguccggc ugauggacgu cugugccaca      240

ucccgaacug accgggagau caagguaacc cugguguuug agcauguaga ccaggaccua      300

aggacauauc uggacaaggc acccccacca ggcuugccag ccgaaacgau caaggaucug      360

augcgccagu uucuaagagg ccuagauuuc cuucaugcca auugcaucgu ucaccgagau      420

cugaagccag agaacauucu ggugacaagu gguggaacag ucaagcuggc ugacuuuggc      480

cuggccagaa ucuacagcua ccagauggca cuuacacccg ugguuguuac acucugguac      540

cgagcucccg aaguucuucu gcaguccaca uaugcaacac cuguggacau guggaguguu      600

ggcuguaucu uugcagagau guuucgucga aagccucucu ucuguggaaa cucugaagcc      660

gaccaguugg gcaaaaucuu ugaccugauu gggcugccuc cagaggauga cuggccucga      720

gauguauccc ugccccgugg agccuuuccc cccagagggc cccgcccagu gcagucggug      780

guaccugaga uggaggaguc gggagcacag cugcugcugg aaaugcugac uuuuaaccca      840

cacaagcgaa ucucugccuu ucgagcucug cagcacucuu aucuacauaa ggaugaaggu      900

aauccggagu ga                                                          912


<210>  995
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDK4/m__Homo_sapiens__EAW97060

<400>  995
auggccacca gccgcuacga gcccguggcc gagaucggcg ucggggcgua cggcaccgug       60

uacaaggccc gggacccgca cuccgggcac uucguggccc ucaagagcgu ccgcgugccc      120

aacggcgggg gcggcggggg cgggcugccc aucuccacgg ugcgggaggu cgcccugcug      180

cgccggcucg aggccuucga gcaccccaac guggugcgcc ugauggacgu cugcgcgacc      240

agccggaccg accgcgagau caaggugacc cugguguucg agcacgucga ccaggaccuc      300

cggacguacc uggacaaggc cccgccgccc ggccugcccg ccgagaccau caaggaccuc      360

augcgccagu uccugcgggg gcuggacuuc cuccacgcca acugcaucgu gcaccgcgac      420

cugaagccgg agaacauccu ggugaccucc ggcggcaccg ucaagcucgc ggacuucggg      480

cuggcccgga ucuacagcua ccagauggcc cugacgcccg ugguggucac ccucugguac      540

cgcgcccccg aggugcugcu gcaguccacc uacgccaccc ccguggacau guggagcguc      600

ggcugcaucu ucgcggagau guuccggcgc aagccccucu ucugcgggaa cuccgaggcc      660

gaccagcugg gcaagaucuu cgaccugauc ggccucccgc ccgaggacga cuggccccgg      720

gacgugagcc ugccccgcgg ggccuucccg ccccggggcc cccgccccgu gcaguccguc      780

gugcccgaga uggaggagag cggggcccag cugcuccugg agaugcugac guucaacccc      840

cacaagcgga ucuccgccuu ccgcgcgcuc cagcacagcu accugcacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  996
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDK4/m__Homo_sapiens__EAW97060

<400>  996
auggccaccu cccgcuacga gcccgucgcc gagaucggcg ucggcgccua cggcaccguc       60

uacaaggccc gcgaccccca cuccggccac uucgucgccc ucaaguccgu ccgcgucccc      120

aacggcggcg gcggcggcgg cggccucccc aucuccaccg uccgcgaggu cgcccuccuc      180

cgccgccucg aggccuucga gcaccccaac gucguccgcc ucauggacgu cugcgccacc      240

ucccgcaccg accgcgagau caaggucacc cucgucuucg agcacgucga ccaggaccuc      300

cgcaccuacc ucgacaaggc cccccccccc ggccuccccg ccgagaccau caaggaccuc      360

augcgccagu uccuccgcgg ccucgacuuc cuccacgcca acugcaucgu ccaccgcgac      420

cucaagcccg agaacauccu cgucaccucc ggcggcaccg ucaagcucgc cgacuucggc      480

cucgcccgca ucuacuccua ccagauggcc cucacccccg ucgucgucac ccucugguac      540

cgcgcccccg agguccuccu ccaguccacc uacgccaccc ccgucgacau gugguccguc      600

ggcugcaucu ucgccgagau guuccgccgc aagccccucu ucugcggcaa cuccgaggcc      660

gaccagcucg gcaagaucuu cgaccucauc ggccuccccc ccgaggacga cuggccccgc      720

gacgucuccc ucccccgcgg cgccuucccc ccccgcggcc cccgccccgu ccaguccguc      780

guccccgaga uggaggaguc cggcgcccag cuccuccucg agaugcucac cuucaacccc      840

cacaagcgca ucuccgccuu ccgcgcccuc cagcacuccu accuccacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  997
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDK4/m__Homo_sapiens__EAW97060

<400>  997
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggcaua uggaacaguu       60

uacaaggcca gggacccuca cuccggucau uucguggcgc ugaaaucugu acgggugcca      120

aacggcgggg gaggcggugg gggacucccg auuucaacug uccgcgaggu ggcucugcuu      180

cgacguuugg aagccuuuga gcaccccaau guugugagau uaauggaugu cugcgcaacg      240

aguaggaccg accgggaaau aaaggugaca cugguauucg agcauguuga ucaggaccua      300

cgcacuuauc ucgauaaagc cccuccaccc ggccugccug cugagaccau caaggaccuu      360

augagacaau uucugagggg cuuggauuuc cuccacgcaa acuguauugu gcaucgggac      420

cugaaaccag aaaauauccu ggucacaagc gggggaaccg ugaagcucgc cgauuuuggu      480

uuagcucgca uuuacuccua ucagauggcc cugacucccg uggucguuac acuuugguac      540

cgagcgccug agguguugcu gcagucuacc uaugcaacgc caguagacau guggucggug      600

ggcugcaucu ucgccgaaau guuuagaagg aagccgcuau ucugugggaa cucagaggcu      660

gaucagcucg gaaaaauauu ugaccugauc ggccuucccc cugaggauga cuggccacgg      720

gacgucagcc ugccccgugg ugccuucccu ccacgcgggc ccagaccggu gcaaaguguu      780

gugccugaaa uggaggaauc cggagcacag uugcuccugg agauguuaac uuuuaauccc      840

cacaagagga uuucugcuuu ccgggcccug cagcacagcu accuccauaa agaugaaggc      900

aacccagagu ga                                                          912


<210>  998
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDK4/m__Homo_sapiens__EAW97060

<400>  998
auggccacca gcagauacga gcccguggcc gagaucggcg ugggcgccua cggcaccgug       60

uacaaggcca gagaccccca cagcggccac uucguggccc ugaagagcgu gagagugccc      120

aacggcggcg gcggcggcgg cggccugccc aucagcaccg ugagagaggu ggcccugcug      180

agaagacugg aggccuucga gcaccccaac guggugagac ugauggacgu gugcgccacc      240

agcagaaccg acagagagau caaggugacc cugguguucg agcacgugga ccaggaccug      300

agaaccuacc uggacaaggc cccccccccc ggccugcccg ccgagaccau caaggaccug      360

augagacagu uccugagagg ccuggacuuc cugcacgcca acugcaucgu gcacagagac      420

cugaagcccg agaacauccu ggugaccagc ggcggcaccg ugaagcuggc cgacuucggc      480

cuggccagaa ucuacagcua ccagauggcc cugacccccg ugguggugac ccugugguac      540

agagcccccg aggugcugcu gcagagcacc uacgccaccc ccguggacau guggagcgug      600

ggcugcaucu ucgccgagau guucagaaga aagccccugu ucugcggcaa cagcgaggcc      660

gaccagcugg gcaagaucuu cgaccugauc ggccugcccc ccgaggacga cuggcccaga      720

gacgugagcc ugcccagagg cgccuucccc cccagaggcc ccagacccgu gcagagcgug      780

gugcccgaga uggaggagag cggcgcccag cugcugcugg agaugcugac cuucaacccc      840

cacaagagaa ucagcgccuu cagagcccug cagcacagcu accugcacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  999
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDK4/m__Homo_sapiens__EAW97060

<400>  999
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggccua uggaacaguu       60

uacaaggcgc gggacccuca cuccggccau uucguggcuc ugaaaucugu gcgcgucccg      120

aacgggggag gcgggggagg cggccucccc auuagcacgg ugagagaggu ugcccugcuu      180

cggcgccugg aagccuuuga gcacccuaau guggucagac ucauggaugu gugcgcuacc      240

ucccggacag accgcgaaau caagguuacc cugguguucg agcaugucga ucaggaccuu      300

agaacauauc uggauaaagc ucccccuccc gggcucccug ccgagaccau uaaggaccug      360

augcggcaau uucugcgcgg acucgauuuc cugcacgcca acuguaucgu gcauagagac      420

cuuaaaccgg aaaauauucu ggugacaucu ggcgggaccg ucaagcucgc ggauuuugga      480

cuggcccgga ucuacagcua ucagauggcu cuuacgcccg uuguggugac ccugugguac      540

cgcgccccug agguccuccu gcaguccaca uaugcuaccc ccguggacau guggucuguu      600

ggcugcaucu ucgccgaaau guuuagacgg aagccucugu ucugugggaa cagcgaggcg      660

gaucagcucg gaaaaauuuu ugaccugauc ggccuucccc cggaggauga cuggccucgc      720

gacguguccc ugcccagagg cgccuucccu ccccgggggc ccagaccugu ccaaagcgug      780

guuccggaaa uggaggaauc uggagcucag cuccugcuug agaugcugac auuuaauccc      840

cacaagcgca uuuccgccuu ccgggcucuc cagcacagcu accugcauaa agaugaaggc      900

aacccugagu ga                                                          912


<210>  1000
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__P11802

<400>  1000

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  1001
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__AAA35673

<400>  1001
auggcuaccu cucgauauga gccaguggcu gaaauuggug ucggugccua ugggacagug       60

uacaaggccc gugaucccca caguggccac uuuguggccc ucaagagugu gagagucccc      120

aauggaggag gagguggagg aggccuuccc aucagcacag uucgugaggu ggcuuuacug      180

aggcgacugg aggcuuuuga gcaucccaau guuguccggc ugauggacgu cugugccaca      240

ucccgaacug accgggagau caagguaacc cugguguuug agcauguaga ccaggaccua      300

aggacauauc uggacaaggc acccccacca ggcuugccag ccgaaacgau caaggaucug      360

augcgccagu uucuaagagg ccuagauuuc cuucaugcca auugcaucgu ucaccgagau      420

cugaagccag agaacauucu ggugacaagu gguggaacag ucaagcuggc ugacuuuggc      480

cuggccagaa ucuacagcua ccagauggca cuuacacccg ugguuguuac acucugguac      540

cgagcucccg aaguucuucu gcaguccaca uaugcaacac cuguggacau guggaguguu      600

ggcuguaucu uugcagagau guuucgucga aagccucucu ucuguggaaa cucugaagcc      660

gaccaguugg gcaaaaucuu ugaccugauu gggcugccuc cagaggauga cuggccucga      720

gauguauccc ugccccgugg agccuuuccc cccagagggc cccgcccagu gcagucggug      780

guaccugaga uggaggaguc gggagcacag cugcugcugg aaaugcugac uuuuaaccca      840

cacaagcgaa ucucugccuu ucgagcucug cagcacucuu aucuacauaa ggaugaaggu      900

aauccggagu ga                                                          912


<210>  1002
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDK4/m__Homo_sapiens__AAA35673

<400>  1002
auggccacca gccgcuacga gcccguggcc gagaucggcg ucggggcgua cggcaccgug       60

uacaaggccc gggacccgca cuccgggcac uucguggccc ucaagagcgu ccgcgugccc      120

aacggcgggg gcggcggggg cgggcugccc aucuccacgg ugcgggaggu cgcccugcug      180

cgccggcucg aggccuucga gcaccccaac guggugcgcc ugauggacgu cugcgcgacc      240

agccggaccg accgcgagau caaggugacc cugguguucg agcacgucga ccaggaccuc      300

cggacguacc uggacaaggc cccgccgccc ggccugcccg ccgagaccau caaggaccuc      360

augcgccagu uccugcgggg gcuggacuuc cuccacgcca acugcaucgu gcaccgcgac      420

cugaagccgg agaacauccu ggugaccucc ggcggcaccg ucaagcucgc ggacuucggg      480

cuggcccgga ucuacagcua ccagauggcc cugacgcccg ugguggucac ccucugguac      540

cgcgcccccg aggugcugcu gcaguccacc uacgccaccc ccguggacau guggagcguc      600

ggcugcaucu ucgcggagau guuccggcgc aagccccucu ucugcgggaa cuccgaggcc      660

gaccagcugg gcaagaucuu cgaccugauc ggccucccgc ccgaggacga cuggccccgg      720

gacgugagcc ugccccgcgg ggccuucccg ccccggggcc cccgccccgu gcaguccguc      780

gugcccgaga uggaggagag cggggcccag cugcuccugg agaugcugac guucaacccc      840

cacaagcgga ucuccgccuu ccgcgcgcuc cagcacagcu accugcacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  1003
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDK4/m__Homo_sapiens__AAA35673

<400>  1003
auggccaccu cccgcuacga gcccgucgcc gagaucggcg ucggcgccua cggcaccguc       60

uacaaggccc gcgaccccca cuccggccac uucgucgccc ucaaguccgu ccgcgucccc      120

aacggcggcg gcggcggcgg cggccucccc aucuccaccg uccgcgaggu cgcccuccuc      180

cgccgccucg aggccuucga gcaccccaac gucguccgcc ucauggacgu cugcgccacc      240

ucccgcaccg accgcgagau caaggucacc cucgucuucg agcacgucga ccaggaccuc      300

cgcaccuacc ucgacaaggc cccccccccc ggccuccccg ccgagaccau caaggaccuc      360

augcgccagu uccuccgcgg ccucgacuuc cuccacgcca acugcaucgu ccaccgcgac      420

cucaagcccg agaacauccu cgucaccucc ggcggcaccg ucaagcucgc cgacuucggc      480

cucgcccgca ucuacuccua ccagauggcc cucacccccg ucgucgucac ccucugguac      540

cgcgcccccg agguccuccu ccaguccacc uacgccaccc ccgucgacau gugguccguc      600

ggcugcaucu ucgccgagau guuccgccgc aagccccucu ucugcggcaa cuccgaggcc      660

gaccagcucg gcaagaucuu cgaccucauc ggccuccccc ccgaggacga cuggccccgc      720

gacgucuccc ucccccgcgg cgccuucccc ccccgcggcc cccgccccgu ccaguccguc      780

guccccgaga uggaggaguc cggcgcccag cuccuccucg agaugcucac cuucaacccc      840

cacaagcgca ucuccgccuu ccgcgcccuc cagcacuccu accuccacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  1004
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDK4/m__Homo_sapiens__AAA35673

<400>  1004
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggcaua uggaacaguu       60

uacaaggcca gggacccuca cuccggucau uucguggcgc ugaaaucugu acgggugcca      120

aacggcgggg gaggcggugg gggacucccg auuucaacug uccgcgaggu ggcucugcuu      180

cgacguuugg aagccuuuga gcaccccaau guugugagau uaauggaugu cugcgcaacg      240

aguaggaccg accgggaaau aaaggugaca cugguauucg agcauguuga ucaggaccua      300

cgcacuuauc ucgauaaagc cccuccaccc ggccugccug cugagaccau caaggaccuu      360

augagacaau uucugagggg cuuggauuuc cuccacgcaa acuguauugu gcaucgggac      420

cugaaaccag aaaauauccu ggucacaagc gggggaaccg ugaagcucgc cgauuuuggu      480

uuagcucgca uuuacuccua ucagauggcc cugacucccg uggucguuac acuuugguac      540

cgagcgccug agguguugcu gcagucuacc uaugcaacgc caguagacau guggucggug      600

ggcugcaucu ucgccgaaau guuuagaagg aagccgcuau ucugugggaa cucagaggcu      660

gaucagcucg gaaaaauauu ugaccugauc ggccuucccc cugaggauga cuggccacgg      720

gacgucagcc ugccccgugg ugccuucccu ccacgcgggc ccagaccggu gcaaaguguu      780

gugccugaaa uggaggaauc cggagcacag uugcuccugg agauguuaac uuuuaauccc      840

cacaagagga uuucugcuuu ccgggcccug cagcacagcu accuccauaa agaugaaggc      900

aacccagagu ga                                                          912


<210>  1005
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDK4/m__Homo_sapiens__AAA35673

<400>  1005
auggccacca gcagauacga gcccguggcc gagaucggcg ugggcgccua cggcaccgug       60

uacaaggcca gagaccccca cagcggccac uucguggccc ugaagagcgu gagagugccc      120

aacggcggcg gcggcggcgg cggccugccc aucagcaccg ugagagaggu ggcccugcug      180

agaagacugg aggccuucga gcaccccaac guggugagac ugauggacgu gugcgccacc      240

agcagaaccg acagagagau caaggugacc cugguguucg agcacgugga ccaggaccug      300

agaaccuacc uggacaaggc cccccccccc ggccugcccg ccgagaccau caaggaccug      360

augagacagu uccugagagg ccuggacuuc cugcacgcca acugcaucgu gcacagagac      420

cugaagcccg agaacauccu ggugaccagc ggcggcaccg ugaagcuggc cgacuucggc      480

cuggccagaa ucuacagcua ccagauggcc cugacccccg ugguggugac ccugugguac      540

agagcccccg aggugcugcu gcagagcacc uacgccaccc ccguggacau guggagcgug      600

ggcugcaucu ucgccgagau guucagaaga aagccccugu ucugcggcaa cagcgaggcc      660

gaccagcugg gcaagaucuu cgaccugauc ggccugcccc ccgaggacga cuggcccaga      720

gacgugagcc ugcccagagg cgccuucccc cccagaggcc ccagacccgu gcagagcgug      780

gugcccgaga uggaggagag cggcgcccag cugcugcugg agaugcugac cuucaacccc      840

cacaagagaa ucagcgccuu cagagcccug cagcacagcu accugcacaa ggacgagggc      900

aaccccgagu ga                                                          912


<210>  1006
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDK4/m__Homo_sapiens__AAA35673

<400>  1006
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggccua uggaacaguu       60

uacaaggcgc gggacccuca cuccggccau uucguggcuc ugaaaucugu gcgcgucccg      120

aacgggggag gcgggggagg cggccucccc auuagcacgg ugagagaggu ugcccugcuu      180

cggcgccugg aagccuuuga gcacccuaau guggucagac ucauggaugu gugcgcuacc      240

ucccggacag accgcgaaau caagguuacc cugguguucg agcaugucga ucaggaccuu      300

agaacauauc uggauaaagc ucccccuccc gggcucccug ccgagaccau uaaggaccug      360

augcggcaau uucugcgcgg acucgauuuc cugcacgcca acuguaucgu gcauagagac      420

cuuaaaccgg aaaauauucu ggugacaucu ggcgggaccg ucaagcucgc ggauuuugga      480

cuggcccgga ucuacagcua ucagauggcu cuuacgcccg uuguggugac ccugugguac      540

cgcgccccug agguccuccu gcaguccaca uaugcuaccc ccguggacau guggucuguu      600

ggcugcaucu ucgccgaaau guuuagacgg aagccucugu ucugugggaa cagcgaggcg      660

gaucagcucg gaaaaauuuu ugaccugauc ggccuucccc cggaggauga cuggccucgc      720

gacguguccc ugcccagagg cgccuucccu ccccgggggc ccagaccugu ccaaagcgug      780

guuccggaaa uggaggaauc uggagcucag cuccugcuug agaugcugac auuuaauccc      840

cacaagcgca uuuccgccuu ccgggcucuc cagcacagcu accugcauaa agaugaaggc      900

aacccugagu ga                                                          912


<210>  1007
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__Q6LC83

<400>  1007

Met Asp Val Cys Ala Thr Ser Arg Thr Asp Arg Glu Ile Lys Val Thr 
1               5                   10                  15      


Leu Val Phe Glu His Val Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys 
            20                  25                  30          


Ala Pro Pro Pro Gly Leu Pro Ala Glu Thr Ile Lys Asp Leu Met Arg 
        35                  40                  45              


Gln Phe Leu Arg Gly Leu Asp Phe Leu His Ala Asn Cys Ile Val His 
    50                  55                  60                  


Arg Asp Leu Lys Pro Glu Asn Ile Leu Val Thr Ser Gly Gly Thr Val 
65                  70                  75                  80  


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala 
                85                  90                  95      


Leu Thr Pro Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu 
            100                 105                 110         


Leu Gln Ser Thr Tyr Ala Thr Pro Val Asp Met Trp Ser Val Gly Cys 
        115                 120                 125             


Ile Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser 
    130                 135                 140                 


Glu Ala Asp Gln Leu Gly Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Asp Asp Trp Pro Arg Asp Val Ser Leu Pro Arg Gly Ala Phe Pro 
                165                 170                 175     


Pro Arg Gly Pro Arg Pro Val Gln Ser Val Val Pro Glu Met Glu Glu 
            180                 185                 190         


Ser Gly Ala Gln Leu Leu Leu Glu Met Leu Thr Phe Asn Pro His Lys 
        195                 200                 205             


Arg Ile Ser Ala Phe Arg Ala Leu Gln His Ser Tyr Leu His Lys Asp 
    210                 215                 220                 


Glu Gly Asn Pro Glu 
225                 


<210>  1008
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__AAB50213

<400>  1008
auggacgucu gugccacauc ccgaacugac cgggagauca agguaacccu gguguuugag       60

cauguagacc aggaccuaag gacauaucug gacaaggcac ccccaccagg cuugccagcc      120

gaaacgauca aggaucugau gcgccaguuu cuaagaggcc uagauuuccu ucaugccaau      180

ugcaucguuc accgagaucu gaagccagag aacauucugg ugacaagugg uggaacaguc      240

aagcuggcug acuuuggccu ggccagaauc uacagcuacc agauggcacu uacacccgug      300

guuguuacac ucugguaccg agcucccgaa guucuucugc aguccacaua ugcaacaccu      360

guggacaugu ggaguguugg cuguaucuuu gcagagaugu uucgucgaaa gccucucuuc      420

uguggaaacu cugaagccga ccaguugggc aaaaucuuug accugauugg gcugccucca      480

gaggaugacu ggccucgaga uguaucccug ccccguggag ccuuuccccc cagagggccc      540

cgcccagugc agucgguggu accugagaug gaggagucgg gagcacagcu gcugcuggaa      600

augcugacuu uuaacccaca caagcgaauc ucugccuuuc gagcucugca gcacucuuau      660

cuacauaagg augaagguaa uccggaguga                                       690


<210>  1009
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDK4/m__Homo_sapiens__AAB50213

<400>  1009
auggacgugu gcgccaccag ccgcaccgac cgggagauca aggucacgcu gguguucgag       60

cacguggacc aggaccuccg caccuaccug gacaaggcgc ccccgcccgg ccugcccgcc      120

gagaccauca aggaccucau gcggcaguuc cugcgcgggc uggacuuccu ccacgccaac      180

ugcaucgucc accgggaccu gaagcccgag aacauccugg ugaccuccgg cgggacggug      240

aagcucgccg acuucggccu ggcccgcauc uacagcuacc agauggcccu gaccccgguc      300

guggugaccc ucugguaccg ggcgcccgag guccugcugc aguccaccua cgccacgccc      360

guggacaugu ggagcguggg gugcaucuuc gccgagaugu uccgccggaa gccccucuuc      420

ugcggcaacu ccgaggccga ccagcugggc aagaucuucg accugaucgg gcucccgccc      480

gaggacgacu ggccccgcga cgucagccug ccccggggcg cguucccgcc ccgcgggccc      540

cggcccgugc aguccguggu cccggagaug gaggagagcg gcgcccagcu gcuccuggag      600

augcugaccu ucaaccccca caagcgcauc uccgccuucc gggcccucca gcacagcuac      660

cugcacaagg acgaggggaa ccccgaguga                                       690


<210>  1010
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDK4/m__Homo_sapiens__AAB50213

<400>  1010
auggacgucu gcgccaccuc ccgcaccgac cgcgagauca aggucacccu cgucuucgag       60

cacgucgacc aggaccuccg caccuaccuc gacaaggccc ccccccccgg ccuccccgcc      120

gagaccauca aggaccucau gcgccaguuc cuccgcggcc ucgacuuccu ccacgccaac      180

ugcaucgucc accgcgaccu caagcccgag aacauccucg ucaccuccgg cggcaccguc      240

aagcucgccg acuucggccu cgcccgcauc uacuccuacc agauggcccu cacccccguc      300

gucgucaccc ucugguaccg cgcccccgag guccuccucc aguccaccua cgccaccccc      360

gucgacaugu gguccgucgg cugcaucuuc gccgagaugu uccgccgcaa gccccucuuc      420

ugcggcaacu ccgaggccga ccagcucggc aagaucuucg accucaucgg ccuccccccc      480

gaggacgacu ggccccgcga cgucucccuc ccccgcggcg ccuucccccc ccgcggcccc      540

cgccccgucc aguccgucgu ccccgagaug gaggaguccg gcgcccagcu ccuccucgag      600

augcucaccu ucaaccccca caagcgcauc uccgccuucc gcgcccucca gcacuccuac      660

cuccacaagg acgagggcaa ccccgaguga                                       690


<210>  1011
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDK4/m__Homo_sapiens__AAB50213

<400>  1011
auggacgugu gcgccaccag cagaacagau agggagauca aggucacucu gguuuucgaa       60

cacguggacc aggaucuccg gacguaccuu gacaaagcuc ccccuccagg ccugccggca      120

gagaccauua aggauuugau gcgccaauuu uuacgagggc uggacuuccu acaugccaac      180

uguauaguac accgugaucu caaacccgaa aauauccugg ugacauccgg agguacuguc      240

aaacuugcgg acuuuggccu ggcuagaauu uauucuuacc agauggccuu gaccccugug      300

guugugacac ucugguauag ggcaccagag guccugcugc agucaaccua cgccacuccc      360

guggauaugu ggaguguagg gugcaucuuc gcugaaaugu uucggcgcaa gccucucuuc      420

uguggaaaca gcgaggcaga ccaguuaggc aagauuuuug aucugaucgg ucuuccaccc      480

gaggacgauu ggccuagaga cguuuccuug ccaaggggag ccuucccgcc ccgggggccu      540

cgcccagugc aaucugucgu gcccgaaaug gaggaaucgg gcgcucagcu gcuacucgag      600

augcugacau uuaauccuca uaagcgaaua ucagccuuca gagcgcuuca gcacagcuau      660

cugcauaaag acgagggcaa cccagaauga                                       690


<210>  1012
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDK4/m__Homo_sapiens__AAB50213

<400>  1012
auggacgugu gcgccaccag cagaaccgac agagagauca aggugacccu gguguucgag       60

cacguggacc aggaccugag aaccuaccug gacaaggccc ccccccccgg ccugcccgcc      120

gagaccauca aggaccugau gagacaguuc cugagaggcc uggacuuccu gcacgccaac      180

ugcaucgugc acagagaccu gaagcccgag aacauccugg ugaccagcgg cggcaccgug      240

aagcuggccg acuucggccu ggccagaauc uacagcuacc agauggcccu gacccccgug      300

guggugaccc ugugguacag agcccccgag gugcugcugc agagcaccua cgccaccccc      360

guggacaugu ggagcguggg cugcaucuuc gccgagaugu ucagaagaaa gccccuguuc      420

ugcggcaaca gcgaggccga ccagcugggc aagaucuucg accugaucgg ccugcccccc      480

gaggacgacu ggcccagaga cgugagccug cccagaggcg ccuucccccc cagaggcccc      540

agacccgugc agagcguggu gcccgagaug gaggagagcg gcgcccagcu gcugcuggag      600

augcugaccu ucaaccccca caagagaauc agcgccuuca gagcccugca gcacagcuac      660

cugcacaagg acgagggcaa ccccgaguga                                       690


<210>  1013
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDK4/m__Homo_sapiens__AAB50213

<400>  1013
auggacgugu gcgccaccag cagaacagau cgggagauca aggucacgcu gguuuucgaa       60

cacguggacc aggaucuccg caccuaccug gacaaagcuc ccccuccggg ccuucccgcc      120

gagacaauua aggaucugau gagacaauuu cuccgggggc uggacuuccu ucaugcgaac      180

uguaucgugc accgcgaucu gaaaccugaa aauauucucg ucaccuccgg aggcacagug      240

aagcuggcug acuuugggcu ggccagaauc uauucuuacc agauggcccu cacccccguu      300

guggucacac ugugguaucg ggcuccugag gugcuucugc agagcaccua cgccacgccc      360

guugauaugu gguccguggg augcauuuuc gcugaaaugu uucgcagaaa accucucuuc      420

uguggcaacu cugaggccga ccagcugggg aagaucuuug aucuuaucgg acugccgccc      480

gaggacgauu ggccucggga cgucagccuc ccccgcggcg cguucccucc cagaggcccg      540

cggccugugc aauccguggu ccccgaaaug gaggaaucug gggcccagcu gcugcucgag      600

augcugaccu uuaauccuca uaagcgcauu agcgcuuuca gagcccuuca gcacuccuau      660

cugcauaaag acgagggaaa ccccgaauga                                       690


<210>  1014
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__Q96BE9

<400>  1014

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Arg Cys Phe Val Glu Ser Leu Ser 
                85                  90                  95      


Ser Val Glu Thr Leu Lys Pro Thr Ser Trp Ala Lys Ser Leu Thr 
            100                 105                 110     


<210>  1015
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDK4/m__Homo_sapiens__AAH15669

<400>  1015
auggcuaccu cucgauauga gccaguggcu gaaauuggug ucggugccua ugggacagug       60

uacaaggccc gugaucccca caguggccac uuuguggccc ucaagagugu gagagucccc      120

aauggaggag gagguggagg aggccuuccc aucagcacag uucgugaggu ggcuuuacug      180

aggcgacugg aggcuuuuga gcaucccaau guuguccggc ugauggacgu cugugccaca      240

ucccgaacug accgggagau caagagaugu uucgucgaaa gccucucuuc uguggaaacu      300

cugaagccga ccaguugggc aaaaucuuug accuga                                336


<210>  1016
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDK4/m__Homo_sapiens__AAH15669

<400>  1016
auggccacca gccgcuacga gcccguggcc gagaucggcg ucggggcgua cggcaccgug       60

uacaaggccc gggacccgca cuccgggcac uucguggccc ucaagagcgu ccgcgugccc      120

aacggcgggg gcggcggggg cgggcugccc aucuccacgg ugcgggaggu cgcccugcug      180

cgccggcucg aggccuucga gcaccccaac guggugcgcc ugauggacgu cugcgcgacc      240

agccggaccg accgcgagau caagcggugc uucguggagu cccugagcuc cguggagacc      300

cucaagccga cgagcugggc caagucccug accuga                                336


<210>  1017
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDK4/m__Homo_sapiens__AAH15669

<400>  1017
auggccaccu cccgcuacga gcccgucgcc gagaucggcg ucggcgccua cggcaccguc       60

uacaaggccc gcgaccccca cuccggccac uucgucgccc ucaaguccgu ccgcgucccc      120

aacggcggcg gcggcggcgg cggccucccc aucuccaccg uccgcgaggu cgcccuccuc      180

cgccgccucg aggccuucga gcaccccaac gucguccgcc ucauggacgu cugcgccacc      240

ucccgcaccg accgcgagau caagcgcugc uucgucgagu cccucuccuc cgucgagacc      300

cucaagccca ccuccugggc caagucccuc accuga                                336


<210>  1018
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDK4/m__Homo_sapiens__AAH15669

<400>  1018
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggcaua uggaacaguu       60

uacaaggcca gggacccuca cuccggucau uucguggcgc ugaaaucugu acgggugcca      120

aacggcgggg gaggcggugg gggacucccg auuucaacug uccgcgaggu ggcucugcuu      180

cgacguuugg aagccuuuga gcaccccaau guugugagau uaauggaugu cugcgcaacg      240

aguaggaccg accgggaaau aaagcgcugu uucguggaga gccuguccuc uguagagaca      300

cuaaaaccua cuucgugggc caagucacuc accuga                                336


<210>  1019
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDK4/m__Homo_sapiens__AAH15669

<400>  1019
auggccacca gcagauacga gcccguggcc gagaucggcg ugggcgccua cggcaccgug       60

uacaaggcca gagaccccca cagcggccac uucguggccc ugaagagcgu gagagugccc      120

aacggcggcg gcggcggcgg cggccugccc aucagcaccg ugagagaggu ggcccugcug      180

agaagacugg aggccuucga gcaccccaac guggugagac ugauggacgu gugcgccacc      240

agcagaaccg acagagagau caagagaugc uucguggaga gccugagcag cguggagacc      300

cugaagccca ccagcugggc caagagccug accuga                                336


<210>  1020
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDK4/m__Homo_sapiens__AAH15669

<400>  1020
auggccacca gcagauacga gcccguggcu gaaaucggcg ucggggccua uggaacaguu       60

uacaaggcgc gggacccuca cuccggccau uucguggcuc ugaaaucugu gcgcgucccg      120

aacgggggag gcgggggagg cggccucccc auuagcacgg ugagagaggu ugcccugcuu      180

cggcgccugg aagccuuuga gcacccuaau guggucagac ucauggaugu gugcgcuacc      240

ucccggacag accgcgaaau caagagaugu uucguugagu cucugagcuc cguggagacc      300

cuuaaaccca caucuugggc caagagccug accuga                                336


<210>  1021
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__D1LYX3

<400>  1021

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Pro Cys Ala Met Pro Gly Ala Val Cys Pro 
            100                 105                 110         


Trp Thr Trp Leu Arg Ser Trp Ala Ile Ala Met Ser His Gly Thr Cys 
        115                 120                 125             


Ala Arg Leu Arg Gly Ala Pro Glu Ala Val Thr Met Pro Ala 
    130                 135                 140         


<210>  1022
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__ACY78326

<400>  1022
auggagccgg cggcggggag cagcauggag ccuucggcug acuggcuggc cacggccgcg       60

gcccgggguc ggguagagga ggugcgggcg cugcuggagg cgggggcgcu gcccaacgca      120

ccgaauaguu acggucggag gccgauccag gucaugauga ugggcagcgc ccgaguggcg      180

gagcugcugc ugcuccacgg cgcggagccc aacugcgccg accccgccac ucucacccga      240

cccgugcacg acgcugcccg ggagggcuuc cuggacacgc ugguggugcu gcaccgggcc      300

ggggcgccgu gcgcgaugcc uggggccguc ugcccgugga ccuggcugag gagcugggcc      360

aucgcgaugu cgcacgguac cugcgcgcgg cugcgggggg caccagaggc aguaaccaug      420

cccgcauag                                                              429


<210>  1023
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDKN2A/m__Homo_sapiens__ACY78326

<400>  1023
auggagcccg ccgccggcag cuccauggag ccgagcgcgg acuggcuggc caccgccgcc       60

gcccgcgggc ggguggagga gguccgcgcg cuccuggagg ccggcgcccu gcccaacgcc      120

cccaacuccu acgggcggcg ccccauccag gugaugauga ugggcagcgc gcggguggcc      180

gagcuccugc ugcuccacgg ggccgagccg aacugcgccg accccgccac ccugacgcgc      240

cccguccacg acgcggcccg ggagggcuuc cuggacaccc ucguggugcu gcaccgcgcc      300

ggcgcccccu gcgccaugcc gggggcgguc ugccccugga ccuggcugcg guccugggcc      360

aucgccauga gccacgggac cugcgcccgc cuccggggcg cccccgaggc ggugacgaug      420

cccgccuga                                                              429


<210>  1024
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDKN2A/m__Homo_sapiens__ACY78326

<400>  1024
auggagcccg ccgccggcuc cuccauggag cccuccgccg acuggcucgc caccgccgcc       60

gcccgcggcc gcgucgagga gguccgcgcc cuccucgagg ccggcgcccu ccccaacgcc      120

cccaacuccu acggccgccg ccccauccag gucaugauga ugggcuccgc ccgcgucgcc      180

gagcuccucc uccuccacgg cgccgagccc aacugcgccg accccgccac ccucacccgc      240

cccguccacg acgccgcccg cgagggcuuc cucgacaccc ucgucguccu ccaccgcgcc      300

ggcgcccccu gcgccaugcc cggcgccguc ugccccugga ccuggcuccg cuccugggcc      360

aucgccaugu cccacggcac cugcgcccgc cuccgcggcg cccccgaggc cgucaccaug      420

cccgccuga                                                              429


<210>  1025
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDKN2A/m__Homo_sapiens__ACY78326

<400>  1025
auggagcccg ccgcuggcag cuccauggaa ccuucugcag acuggcuggc caccgcggcu       60

gccagaggga ggguggagga aguccgggca cuccuugagg ccggagcucu gccaaacgca      120

cccaauucau acggucgccg accgauccag guuaugauga ugggcagugc ccguguggcu      180

gaauuguuac ugcuacacgg ggccgagccu aacugcgcgg auccagcaac acucacuaga      240

cccguacaug acgccgcuag ggagggauuc cuggauacgc uugugguccu gcaccgggcc      300

ggcgcaccuu gugcuaugcc aggugccgug ugccccugga ccugguugcg cagcugggcg      360

auugccaugu cccaugggac augugcaaga cucaggggag cuccugaagc cguuacuaug      420

ccagcuuga                                                              429


<210>  1026
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDKN2A/m__Homo_sapiens__ACY78326

<400>  1026
auggagcccg ccgccggcag cagcauggag cccagcgccg acuggcuggc caccgccgcc       60

gccagaggca gaguggagga ggugagagcc cugcuggagg ccggcgcccu gcccaacgcc      120

cccaacagcu acggcagaag acccauccag gugaugauga ugggcagcgc cagaguggcc      180

gagcugcugc ugcugcacgg cgccgagccc aacugcgccg accccgccac ccugaccaga      240

cccgugcacg acgccgccag agagggcuuc cuggacaccc ugguggugcu gcacagagcc      300

ggcgcccccu gcgccaugcc cggcgccgug ugccccugga ccuggcugag aagcugggcc      360

aucgccauga gccacggcac cugcgccaga cugagaggcg cccccgaggc cgugaccaug      420

cccgccuga                                                              429


<210>  1027
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDKN2A/m__Homo_sapiens__ACY78326

<400>  1027
auggagcccg ccgcuggcag cuccauggaa ccuucugccg acuggcuggc gaccgcugcc       60

gccagagggc ggguggagga aguccgcgcu cuccuggagg ccggagcccu uccgaacgcu      120

cccaauagcu acggcagacg gccuauccag guuaugauga ugggguccgc gcgcguggcc      180

gaacugcucc ugcuucacgg agcugagccc aacugcgccg auccugcuac acugacgaga      240

cccgugcaug acgccgcgcg ggagggcuuc cucgauaccc uggucgugcu gcaccgcgcc      300

ggggcuccuu gugccaugcc gggagcuguu ugccccugga cauggcucag aucuugggcc      360

auugccauga gccauggcac cugugcucgg cugcgcggcg cgccugaagc cgugacaaug      420

cccgcuuga                                                              429


<210>  1028
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__G3XAG3

<400>  1028

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly Asp Gly Gly Arg 
    50                  55                  60                  


Leu Trp Arg Thr Lys Phe Ala Gly Glu Leu Glu Ser Gly Ser Ala Ser 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Gly Arg Leu Pro Gly Glu Phe Ser Glu Gly Val 
                85                  90                  95      


Cys Asn His Arg Pro Pro Pro Gly Asp Ala Leu Gly Ala Trp Glu Ala 
            100                 105                 110         


Lys Glu Glu Glu 
        115     


<210>  1029
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__EAW58598

<400>  1029
auggagccgg cggcggggag cagcauggag ccuucggcug acuggcuggc cacggccgcg       60

gcccgggguc ggguagagga ggugcgggcg cugcuggagg cgggggcgcu gcccaacgca      120

ccgaauaguu acggucggag gccgauccag guggguagag ggucugcagc gggagcaggg      180

gauggcgggc gacucuggag gacgaaguuu gcaggggaau uggaaucagg uagcgcuucg      240

auucuccgga aaaaggggag gcuuccuggg gaguuuucag aagggguuug uaaucacaga      300

ccuccuccug gcgacgcccu gggggcuugg gaagccaagg aagaggaaug a               351


<210>  1030
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDKN2A/m__Homo_sapiens__EAW58598

<400>  1030
auggagcccg ccgccggcag cuccauggag cccagcgcgg acuggcuggc caccgccgcc       60

gcccgcgggc ggguggagga gguccgcgcg cuccuggagg ccggcgcccu gcccaacgcc      120

cccaacuccu acgggcggcg ccccauccag gugggccggg ggagcgcggc cggcgccggc      180

gacgggggcc gccucuggcg gaccaaguuc gccggggagc uggaguccgg cagcgccucc      240

auccugcgca agaaggggcg gcuccccggc gaguucagcg agggcgugug caaccaccgc      300

ccgccgcccg gggacgcgcu gggcgccugg gaggccaagg aggaggagug a               351


<210>  1031
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDKN2A/m__Homo_sapiens__EAW58598

<400>  1031
auggagcccg ccgccggcuc cuccauggag cccuccgccg acuggcucgc caccgccgcc       60

gcccgcggcc gcgucgagga gguccgcgcc cuccucgagg ccggcgcccu ccccaacgcc      120

cccaacuccu acggccgccg ccccauccag gucggccgcg gcuccgccgc cggcgccggc      180

gacggcggcc gccucuggcg caccaaguuc gccggcgagc ucgaguccgg cuccgccucc      240

auccuccgca agaagggccg ccuccccggc gaguucuccg agggcgucug caaccaccgc      300

cccccccccg gcgacgcccu cggcgccugg gaggccaagg aggaggagug a               351


<210>  1032
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDKN2A/m__Homo_sapiens__EAW58598

<400>  1032
auggagcccg ccgcuggcag cuccauggaa ccuucugcag acuggcuggc caccgcggcu       60

gccagaggga ggguggagga aguccgggca cuccuugagg ccggagcucu gccaaacgca      120

cccaauucau acggucgccg accgauccag guuggccgug ggagugccgc uggagccggc      180

gaugguggga gauuguggag gacaaaguuc gcgggagaau uagagagcgg cuccgcaucu      240

auucugcgga aaaagggccg ccuaccuggg gaguuuucgg aaggagugug caaccacaga      300

ccacccccug gugacgcccu cggcgcuugg gaggccaaag aagaggagug a               351


<210>  1033
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDKN2A/m__Homo_sapiens__EAW58598

<400>  1033
auggagcccg ccgccggcag cagcauggag cccagcgccg acuggcuggc caccgccgcc       60

gccagaggca gaguggagga ggugagagcc cugcuggagg ccggcgcccu gcccaacgcc      120

cccaacagcu acggcagaag acccauccag gugggcagag gcagcgccgc cggcgccggc      180

gacggcggca gacuguggag aaccaaguuc gccggcgagc uggagagcgg cagcgccagc      240

auccugagaa agaagggcag acugcccggc gaguucagcg agggcgugug caaccacaga      300

cccccccccg gcgacgcccu gggcgccugg gaggccaagg aggaggagug a               351


<210>  1034
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDKN2A/m__Homo_sapiens__EAW58598

<400>  1034
auggagcccg ccgcuggcag cuccauggaa ccuucugccg acuggcuggc gaccgcugcc       60

gccagagggc ggguggagga aguccgcgcu cuccuggagg ccggagcccu uccgaacgcu      120

cccaauagcu acggcagacg gccuauccag guugggcgcg gauccgcggc cggcgcuggg      180

gauggaggca gacuguggcg gacaaaguuc gccggcgaac ucgagucugg gagcgcuucc      240

auucugcgca aaaagggaag acuucccggc gaguuuucug aaggggugug caaccaccgg      300

ccucccccug gagacgcccu gggcgcgugg gaggccaaag aagaggagug a               351


<210>  1035
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__K7PML8

<400>  1035

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  1036
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__AFN61598

<400>  1036
auggagccgg cggcggggag cagcauggag ccuucggcug acuggcuggc cacggccgcg       60

gcccgggguc ggguagagga ggugcgggcg cugcuggagg cgggggcgcu gcccaacgca      120

ccgaauaguu acggucggag gccgauccag gucaugauga ugggcagcgc ccgaguggcg      180

gagcugcugc ugcuccacgg cgcggagccc aacugcgccg accccgccac ucucacccga      240

cccgugcacg acgcugcccg ggagggcuuc cuggacacgc ugguggugcu gcaccgggcc      300

ggggcgcggc uggacgugcg cgaugccugg ggccgucugc ccguggaccu ggcugaggag      360

cugggccauc gcgaugucgc acgguaccug cgcgcggcug cggggggcac cagaggcagu      420

aaccaugccc gcauagaugc cgcggaaggu cccucagaca uccccgauug a               471


<210>  1037
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDKN2A/m__Homo_sapiens__AFN61598

<400>  1037
auggagcccg ccgccggcag cuccauggag ccgagcgcgg acuggcuggc caccgccgcc       60

gcccgcgggc ggguggagga gguccgcgcg cuccuggagg ccggcgcccu gcccaacgcc      120

cccaacuccu acgggcggcg ccccauccag gugaugauga ugggcagcgc gcggguggcc      180

gagcuccugc ugcuccacgg ggccgagccg aacugcgccg accccgccac ccugacgcgc      240

cccguccacg acgcggcccg ggagggcuuc cuggacaccc ucguggugcu gcaccgcgcc      300

ggcgcccggc uggacguccg cgacgccugg gggcggcucc ccguggaccu ggcggaggag      360

cugggccacc gcgacguggc ccgguaccuc cgcgccgccg ccgggggcac ccgggggucc      420

aaccacgcgc gcaucgacgc cgccgagggc ccgagcgaca uccccgacug a               471


<210>  1038
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDKN2A/m__Homo_sapiens__AFN61598

<400>  1038
auggagcccg ccgccggcuc cuccauggag cccuccgccg acuggcucgc caccgccgcc       60

gcccgcggcc gcgucgagga gguccgcgcc cuccucgagg ccggcgcccu ccccaacgcc      120

cccaacuccu acggccgccg ccccauccag gucaugauga ugggcuccgc ccgcgucgcc      180

gagcuccucc uccuccacgg cgccgagccc aacugcgccg accccgccac ccucacccgc      240

cccguccacg acgccgcccg cgagggcuuc cucgacaccc ucgucguccu ccaccgcgcc      300

ggcgcccgcc ucgacguccg cgacgccugg ggccgccucc ccgucgaccu cgccgaggag      360

cucggccacc gcgacgucgc ccgcuaccuc cgcgccgccg ccggcggcac ccgcggcucc      420

aaccacgccc gcaucgacgc cgccgagggc cccuccgaca uccccgacug a               471


<210>  1039
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDKN2A/m__Homo_sapiens__AFN61598

<400>  1039
auggagcccg ccgcuggcag cuccauggaa ccuucugcag acuggcuggc caccgcggcu       60

gccagaggga ggguggagga aguccgggca cuccuugagg ccggagcucu gccaaacgca      120

cccaauucau acggucgccg accgauccag guuaugauga ugggcagugc ccguguggcu      180

gaauuguuac ugcuacacgg ggccgagccu aacugcgcgg auccagcaac acucacuaga      240

cccguacaug acgccgcuag ggagggauuc cuggauacgc uugugguccu gcaccgggcc      300

ggcgcacgcu uggacgugag agaugcuugg gguaggcucc cuguugaccu ggccgaggaa      360

cuggggcauc gggauguggc gcgcuaucuc cgagccgcag cuggaggcac cagaggcagc      420

aaucacgcca ggauugacgc ugccgaaggg ccauccgaua uacccgacug a               471


<210>  1040
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDKN2A/m__Homo_sapiens__AFN61598

<400>  1040
auggagcccg ccgccggcag cagcauggag cccagcgccg acuggcuggc caccgccgcc       60

gccagaggca gaguggagga ggugagagcc cugcuggagg ccggcgcccu gcccaacgcc      120

cccaacagcu acggcagaag acccauccag gugaugauga ugggcagcgc cagaguggcc      180

gagcugcugc ugcugcacgg cgccgagccc aacugcgccg accccgccac ccugaccaga      240

cccgugcacg acgccgccag agagggcuuc cuggacaccc ugguggugcu gcacagagcc      300

ggcgccagac uggacgugag agacgccugg ggcagacugc ccguggaccu ggccgaggag      360

cugggccaca gagacguggc cagauaccug agagccgccg ccggcggcac cagaggcagc      420

aaccacgcca gaaucgacgc cgccgagggc cccagcgaca uccccgacug a               471


<210>  1041
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDKN2A/m__Homo_sapiens__AFN61598

<400>  1041
auggagcccg ccgcuggcag cuccauggaa ccuucugccg acuggcuggc gaccgcugcc       60

gccagagggc ggguggagga aguccgcgcu cuccuggagg ccggagcccu uccgaacgcu      120

cccaauagcu acggcagacg gccuauccag guuaugauga ugggguccgc gcgcguggcc      180

gaacugcucc ugcuucacgg agcugagccc aacugcgccg auccugcuac acugacgaga      240

cccgugcaug acgccgcgcg ggagggcuuc cucgauaccc uggucgugcu gcaccgcgcc      300

ggggcuagac ucgacguucg ggaugccugg ggacgccugc cuguggaccu ugcugaggaa      360

cugggccaua gagaugucgc ccgguaucuc cgcgccgcug cgggcgggac aagaggaucu      420

aaucacgccc ggauugacgc ugccgaaggc ccgagcgaua uccccgacug a               471


<210>  1042
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__L8E941

<400>  1042

Met Glu Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
1               5                   10                  15      


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
            20                  25                  30          


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
        35                  40                  45              


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
    50                  55                  60                  


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
65                  70                  75                  80  


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
                85                  90                  95      


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105             


<210>  1043
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1043
auggaaguca ugaugauggg cagcgcccga guggcggagc ugcugcugcu ccacggcgcg       60

gagcccaacu gcgccgaccc cgccacucuc acccgacccg ugcacgacgc ugcccgggag      120

ggcuuccugg acacgcuggu ggugcugcac cgggccgggg cgcggcugga cgugcgcgau      180

gccuggggcc gucugcccgu ggaccuggcu gaggagcugg gccaucgcga ugucgcacgg      240

uaccugcgcg cggcugcggg gggcaccaga ggcaguaacc augcccgcau agaugccgcg      300

gaaggucccu cagacauccc cgauuga                                          327


<210>  1044
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1044
auggagguga ugaugauggg cagcgcccgc gucgccgagc ugcuccugcu gcacggggcg       60

gagcccaacu gcgccgaccc ggccacccuc acccggcccg ugcacgacgc cgcccgcgag      120

ggcuuccugg acacgcuggu gguccuccac cgggcggggg cccgccugga cgugcgggac      180

gccuggggcc gccugcccgu ggaccucgcc gaggagcugg ggcaccggga cgucgcgcgc      240

uaccugcggg ccgccgccgg cggcacccgc ggguccaacc acgcccggau cgacgcggcc      300

gagggcccca gcgacauccc ggacuga                                          327


<210>  1045
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1045
auggagguca ugaugauggg cuccgcccgc gucgccgagc uccuccuccu ccacggcgcc       60

gagcccaacu gcgccgaccc cgccacccuc acccgccccg uccacgacgc cgcccgcgag      120

ggcuuccucg acacccucgu cguccuccac cgcgccggcg cccgccucga cguccgcgac      180

gccuggggcc gccuccccgu cgaccucgcc gaggagcucg gccaccgcga cgucgcccgc      240

uaccuccgcg ccgccgccgg cggcacccgc ggcuccaacc acgcccgcau cgacgccgcc      300

gagggccccu ccgacauccc cgacuga                                          327


<210>  1046
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1046
auggagguga ugaugauggg cagcgccaga gucgcugaac ugcuccuucu gcacggggca       60

gagcccaacu gcgccgaccc ugcgaccuug acaaggccag uucaugaugc ugcccgggaa      120

ggauucuuag acacucuggu gguacuacac cgcgccggug cacgacucga ugugcgugac      180

gcuuggggca gacugccggu cgaucuugca gaggaacugg ggcauaggga cguggcccgg      240

uacuugcgcg cugccgcggg aggcacgaga gguuccaauc acgcaaggau cgaugccgcu      300

gaggggcccu cugacauucc ugauuga                                          327


<210>  1047
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1047
auggagguga ugaugauggg cagcgccaga guggccgagc ugcugcugcu gcacggcgcc       60

gagcccaacu gcgccgaccc cgccacccug accagacccg ugcacgacgc cgccagagag      120

ggcuuccugg acacccuggu ggugcugcac agagccggcg ccagacugga cgugagagac      180

gccuggggca gacugcccgu ggaccuggcc gaggagcugg gccacagaga cguggccaga      240

uaccugagag ccgccgccgg cggcaccaga ggcagcaacc acgccagaau cgacgccgcc      300

gagggcccca gcgacauccc cgacuga                                          327


<210>  1048
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDKN2A/m__Homo_sapiens__CCQ43815

<400>  1048
auggagguga ugaugauggg cagcgccaga gucgcugaac ugcuccugcu ucacggggcc       60

gagcccaacu gcgcggaccc ugcuacccug acacggccgg uucaugaugc cgcccgcgaa      120

ggauuccucg acacgcuggu ggugcuucac agagcuggcg cccggcugga uguccgcgac      180

gcuuggggga gacuccccgu ggaucuggcc gaggaacugg gacaucggga cguugcgcgc      240

uaccucagag ccgcugccgg cgggacccgg ggauccaauc acgcucgcau cgaugccgcg      300

gagggcccuu cugacauucc cgauuga                                          327


<210>  1049
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__Q8N726

<400>  1049

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg Leu Thr Gly 
            20                  25                  30          


Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu Val Leu Met 
        35                  40                  45              


Leu Leu Arg Ser Gln Arg Leu Gly Gln Gln Pro Leu Pro Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Arg Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His Pro Thr Arg 
                85                  90                  95      


Ala Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly Gly Ala Ala 
            100                 105                 110         


Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly Pro Ser Ala 
        115                 120                 125             


Arg Gly Pro Gly 
    130         


<210>  1050
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CDKN2A/m__Homo_sapiens__AAA82236

<400>  1050
auggugcgca gguucuuggu gacccuccgg auucggcgcg cgugcggccc gccgcgagug       60

aggguuuucg ugguucacau cccgcggcuc acgggggagu gggcagcgcc aggggcgccc      120

gccgcugugg cccucgugcu gaugcuacug aggagccagc gucuagggca gcagccgcuu      180

ccuagaagac caggucauga ugaugggcag cgcccgagug gcggagcugc ugcugcucca      240

cggcgcggag cccaacugcg ccgaccccgc cacucucacc cgacccgugc acgacgcugc      300

ccgggagggc uuccuggaca cgcugguggu gcugcaccgg gccggggcgc ggcuggacgu      360

gcgcgaugcc uggggccguc ugcccgugga ccuggcuga                             399


<210>  1051
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CDKN2A/m__Homo_sapiens__AAA82236

<400>  1051
auggugcgcc gguuccuggu cacccuccgc auccggcgcg ccugcgggcc cccgcgggug       60

cgcguguucg ucgugcacau cccccggcug accggggagu gggccgcgcc cggcgccccc      120

gccgccgugg cccugguccu caugcugcug cgcagccagc ggcucgggca gcagccgcug      180

ccccgccggc ccggccacga cgacgggcag cgccccuccg gcggcgcggc cgccgccccg      240

cggcgcgggg cgcagcugcg gcgcccccgg cacagccacc ccacgcgcgc ccggcgcugc      300

cccggcgggc ucccgggcca cgccgggggc gccgcccccg gccggggcgc ggccggccgc      360

gcccgcugcc uggggcccuc cgcccggggc cccggcuga                             399


<210>  1052
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CDKN2A/m__Homo_sapiens__AAA82236

<400>  1052
augguccgcc gcuuccucgu cacccuccgc auccgccgcg ccugcggccc cccccgcguc       60

cgcgucuucg ucguccacau cccccgccuc accggcgagu gggccgcccc cggcgccccc      120

gccgccgucg cccucguccu caugcuccuc cgcucccagc gccucggcca gcagccccuc      180

ccccgccgcc ccggccacga cgacggccag cgccccuccg gcggcgccgc cgccgccccc      240

cgccgcggcg cccagcuccg ccgcccccgc cacucccacc ccacccgcgc ccgccgcugc      300

cccggcggcc uccccggcca cgccggcggc gccgcccccg gccgcggcgc cgccggccgc      360

gcccgcugcc ucggccccuc cgcccgcggc cccggcuga                             399


<210>  1053
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CDKN2A/m__Homo_sapiens__AAA82236

<400>  1053
auggugagaa gguuccuggu cacccuccgg auccgccgag ccugcgggcc cccucguguu       60

agaguguuug uagugcacau uccaaggcuu acaggcgagu gggcugcacc gggagccccc      120

gcggcugucg cccugguguu gauguuacug cggagccagc gccuagguca acagccucuc      180

ccaagaaggc ccggccauga cgaugggcag cggccuuccg gaggcgcagc cgcugcacca      240

cgccgaggug cccagcugag aaggccccgg cacucucauc cuacucgugc ucgcagaugu      300

ccagggggac uuccgggcca cgccggcggg gcggcacccg gaaggggugc cgcuggccgg      360

gcccgaugcc uggggccuuc agcacgcgga ccaggcuga                             399


<210>  1054
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CDKN2A/m__Homo_sapiens__AAA82236

<400>  1054
auggugagaa gauuccuggu gacccugaga aucagaagag ccugcggccc ccccagagug       60

agaguguucg uggugcacau ccccagacug accggcgagu gggccgcccc cggcgccccc      120

gccgccgugg cccuggugcu gaugcugcug agaagccaga gacugggcca gcagccccug      180

cccagaagac ccggccacga cgacggccag agacccagcg gcggcgccgc cgccgccccc      240

agaagaggcg cccagcugag aagacccaga cacagccacc ccaccagagc cagaagaugc      300

cccggcggcc ugcccggcca cgccggcggc gccgcccccg gcagaggcgc cgccggcaga      360

gccagaugcc ugggccccag cgccagaggc cccggcuga                             399


<210>  1055
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CDKN2A/m__Homo_sapiens__AAA82236

<400>  1055
auggugagac gguuccuggu cacccuccgc aucagacggg ccugcgggcc cccucgcguu       60

agaguguuug ugguccacau uccgcggcug acaggcgagu gggcugcccc cggagcgccu      120

gcugccgugg cccuuguucu gaugcuccug cgcagccaga gacuuggcca acagccccug      180

ccucggcgcc ccgggcauga cgauggacag agaccuuccg gcggggcugc cgcugccccg      240

cggcgcggag cgcagcucag acggccccgc cacucucauc cuacgagagc ccggagaugu      300

cccggcggcc ugccugggca cgcuggaggc gccgcucccg ggcgcggagc cgcgggccgg      360

gccagaugcc uggggccgag cgcucgcgga ccuggcuga                             399


<210>  1056
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CEA__Homo_sapiens__NP_004354

<400>  1056

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  1057
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CEA__Homo_sapiens__CCDS12584.1

<400>  1057
auggagucuc ccucggcccc uccccacaga uggugcaucc ccuggcagag gcuccugcuc       60

acagccucac uucuaaccuu cuggaacccg cccaccacug ccaagcucac uauugaaucc      120

acgccguuca augucgcaga ggggaaggag gugcuucuac uuguccacaa ucugccccag      180

caucuuuuug gcuacagcug guacaaaggu gaaagagugg auggcaaccg ucaaauuaua      240

ggauauguaa uaggaacuca acaagcuacc ccagggcccg cauacagugg ucgagagaua      300

auauacccca augcaucccu gcugauccag aacaucaucc agaaugacac aggauucuac      360

acccuacacg ucauaaaguc agaucuugug aaugaagaag caacuggcca guuccgggua      420

uacccggagc ugcccaagcc cuccaucucc agcaacaacu ccaaacccgu ggaggacaag      480

gaugcugugg ccuucaccug ugaaccugag acucaggacg caaccuaccu guggugggua      540

aacaaucaga gccucccggu cagucccagg cugcagcugu ccaauggcaa caggacccuc      600

acucuauuca augucacaag aaaugacaca gcaagcuaca aaugugaaac ccagaaccca      660

gugagugcca ggcgcaguga uucagucauc cugaaugucc ucuauggccc ggaugccccc      720

accauuuccc cucuaaacac aucuuacaga ucaggggaaa aucugaaccu cuccugccac      780

gcagccucua acccaccugc acaguacucu ugguuuguca augggacuuu ccagcaaucc      840

acccaagagc ucuuuauccc caacaucacu gugaauaaua guggauccua uacgugccaa      900

gcccauaacu cagacacugg ccucaauagg accacaguca cgacgaucac agucuaugca      960

gagccaccca aacccuucau caccagcaac aacuccaacc ccguggagga ugaggaugcu     1020

guagccuuaa ccugugaacc ugagauucag aacacaaccu accuguggug gguaaauaau     1080

cagagccucc cggucagucc caggcugcag cuguccaaug acaacaggac ccucacucua     1140

cucaguguca caaggaauga uguaggaccc uaugagugug gaauccagaa cgaauuaagu     1200

guugaccaca gcgacccagu cauccugaau guccucuaug gcccagacga ccccaccauu     1260

ucccccucau acaccuauua ccguccaggg gugaaccuca gccucuccug ccaugcagcc     1320

ucuaacccac cugcacagua uucuuggcug auugauggga acauccagca acacacacaa     1380

gagcucuuua ucuccaacau cacugagaag aacagcggac ucuauaccug ccaggccaau     1440

aacucagcca guggccacag caggacuaca gucaagacaa ucacagucuc ugcggagcug     1500

cccaagcccu ccaucuccag caacaacucc aaacccgugg aggacaagga ugcuguggcc     1560

uucaccugug aaccugaggc ucagaacaca accuaccugu gguggguaaa uggucagagc     1620

cucccaguca gucccaggcu gcagcugucc aauggcaaca ggacccucac ucuauucaau     1680

gucacaagaa augacgcaag agccuaugua uguggaaucc agaacucagu gagugcaaac     1740

cgcagugacc cagucacccu ggauguccuc uaugggccgg acacccccau cauuuccccc     1800

ccagacucgu cuuaccuuuc gggagcgaac cucaaccucu ccugccacuc ggccucuaac     1860

ccauccccgc aguauucuug gcguaucaau gggauaccgc agcaacacac acaaguucuc     1920

uuuaucgcca aaaucacgcc aaauaauaac gggaccuaug ccuguuuugu cucuaacuug     1980

gcuacuggcc gcaauaauuc cauagucaag agcaucacag ucucugcauc uggaacuucu     2040

ccuggucucu cagcuggggc cacugucggc aucaugauug gagugcuggu ugggguugcu     2100

cugauauag                                                             2109


<210>  1058
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CEA__Homo_sapiens__CCDS12584.1

<400>  1058
auggagagcc ccuccgcccc gccccaccgc uggugcaucc ccuggcagcg gcugcuccug       60

accgccagcc ugcucaccuu cuggaacccg cccacgaccg cgaagcugac caucgagucc      120

acccccuuca acguggccga gggcaaggag guccugcucc uggugcacaa ccugccccag      180

caccucuucg gguacagcug guacaagggc gagcgcgugg acgggaaccg gcagaucauc      240

ggcuacguca ucgggacgca gcaggccacc cccggcccgg ccuacuccgg ccgcgagauc      300

aucuacccca acgccagccu gcugauccag aacaucaucc agaacgacac cggguucuac      360

acccuccacg ugaucaaguc cgaccuggug aacgaggagg cgacgggcca guuccggguc      420

uaccccgagc ugcccaagcc gagcaucucc agcaacaacu ccaagcccgu ggaggacaag      480

gacgccgugg ccuucacgug cgagcccgag acccaggacg ccaccuaccu cugguggguc      540

aacaaccaga gccugcccgu guccccgcgc cugcagcuca gcaacgggaa ccggacgcug      600

acccuguuca acgugacccg caacgacacc gcguccuaca agugcgagac gcagaacccc      660

gucagcgccc ggcgcuccga cagcgugauc cucaacgugc uguacggccc cgacgccccc      720

accaucuccc cgcugaacac cagcuaccgg agcggggaga accucaaccu guccugccac      780

gccgccagca acccgcccgc gcaguacucc ugguucguca acggcaccuu ccagcagagc      840

acgcaggagc uguucauccc caacaucacc gugaacaacu ccggcagcua cacgugccag      900

gcccacaacu ccgacaccgg gcucaaccgc accaccguga ccaccaucac ggucuacgcc      960

gagccgccca agcccuucau caccagcaac aacuccaacc ccguggagga cgaggacgcc     1020

guggcccuga ccugcgagcc cgagauccag aacaccacgu accuguggug ggucaacaac     1080

cagagccucc ccgugagccc ccggcugcag cuguccaacg acaaccgcac ccucacccug     1140

cuguccguga cccggaacga cgucggcccg uacgagugcg ggauccagaa cgagcucagc     1200

guggaccacu ccgaccccgu cauccugaac gugcuguacg gccccgacga ccccacgauc     1260

agcccguccu acaccuacua ccgccccggc gugaaccuca gccuguccug ccacgcggcc     1320

agcaacccgc ccgcccagua cagcuggcug aucgacggga acauccagca gcacacccag     1380

gagcuguuca ucuccaacau caccgagaag aacagcggcc ucuacacgug ccaggccaac     1440

aacuccgcca gcgggcacuc ccggaccacc gucaagacca ucaccgugag cgcggagcug     1500

cccaagcccu ccaucagcuc caacaacagc aagcccgugg aggacaagga cgccgucgcc     1560

uucacgugcg agcccgaggc ccagaacacc accuaccucu ggugggugaa cggccagucc     1620

cugccgguga gcccccgccu gcagcucucc aacgggaacc ggacccugac gcuguucaac     1680

gucacccgca acgacgcccg ggcguacgug ugcggcaucc agaacagcgu guccgccaac     1740

cgcagcgacc ccgucacccu ggacgugcuc uacggccccg acaccccgau caucuccccg     1800

cccgacagca gcuaccuguc cggggccaac cugaaccuca gcugccacuc cgccagcaac     1860

cccagccccc aguacuccug gcgcaucaac ggcauccccc agcagcacac ccaggugcug     1920

uucaucgcga agaucacccc caacaacaac gggaccuacg ccugcuucgu cuccaaccug     1980

gccaccggcc ggaacaacag caucgugaag uccaucacgg ugagcgccuc cgggaccagc     2040

cccggccucu ccgccggcgc gaccgucggg aucaugaucg gcgugcuggu gggggucgcc     2100

cugaucuga                                                             2109


<210>  1059
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CEA__Homo_sapiens__CCDS12584.1

<400>  1059
auggaguccc ccuccgcccc cccccaccgc uggugcaucc ccuggcagcg ccuccuccuc       60

accgccuccc uccucaccuu cuggaacccc cccaccaccg ccaagcucac caucgagucc      120

acccccuuca acgucgccga gggcaaggag guccuccucc ucguccacaa ccucccccag      180

caccucuucg gcuacuccug guacaagggc gagcgcgucg acggcaaccg ccagaucauc      240

ggcuacguca ucggcaccca gcaggccacc cccggccccg ccuacuccgg ccgcgagauc      300

aucuacccca acgccucccu ccucauccag aacaucaucc agaacgacac cggcuucuac      360

acccuccacg ucaucaaguc cgaccucguc aacgaggagg ccaccggcca guuccgcguc      420

uaccccgagc uccccaagcc cuccaucucc uccaacaacu ccaagcccgu cgaggacaag      480

gacgccgucg ccuucaccug cgagcccgag acccaggacg ccaccuaccu cugguggguc      540

aacaaccagu cccuccccgu cuccccccgc cuccagcucu ccaacggcaa ccgcacccuc      600

acccucuuca acgucacccg caacgacacc gccuccuaca agugcgagac ccagaacccc      660

gucuccgccc gccgcuccga cuccgucauc cucaacgucc ucuacggccc cgacgccccc      720

accaucuccc cccucaacac cuccuaccgc uccggcgaga accucaaccu cuccugccac      780

gccgccucca acccccccgc ccaguacucc ugguucguca acggcaccuu ccagcagucc      840

acccaggagc ucuucauccc caacaucacc gucaacaacu ccggcuccua caccugccag      900

gcccacaacu ccgacaccgg ccucaaccgc accaccguca ccaccaucac cgucuacgcc      960

gagcccccca agcccuucau caccuccaac aacuccaacc ccgucgagga cgaggacgcc     1020

gucgcccuca ccugcgagcc cgagauccag aacaccaccu accucuggug ggucaacaac     1080

cagucccucc ccgucucccc ccgccuccag cucuccaacg acaaccgcac ccucacccuc     1140

cucuccguca cccgcaacga cgucggcccc uacgagugcg gcauccagaa cgagcucucc     1200

gucgaccacu ccgaccccgu cauccucaac guccucuacg gccccgacga ccccaccauc     1260

ucccccuccu acaccuacua ccgccccggc gucaaccucu cccucuccug ccacgccgcc     1320

uccaaccccc ccgcccagua cuccuggcuc aucgacggca acauccagca gcacacccag     1380

gagcucuuca ucuccaacau caccgagaag aacuccggcc ucuacaccug ccaggccaac     1440

aacuccgccu ccggccacuc ccgcaccacc gucaagacca ucaccgucuc cgccgagcuc     1500

cccaagcccu ccaucuccuc caacaacucc aagcccgucg aggacaagga cgccgucgcc     1560

uucaccugcg agcccgaggc ccagaacacc accuaccucu ggugggucaa cggccagucc     1620

cuccccgucu ccccccgccu ccagcucucc aacggcaacc gcacccucac ccucuucaac     1680

gucacccgca acgacgcccg cgccuacguc ugcggcaucc agaacuccgu cuccgccaac     1740

cgcuccgacc ccgucacccu cgacguccuc uacggccccg acacccccau caucuccccc     1800

cccgacuccu ccuaccucuc cggcgccaac cucaaccucu ccugccacuc cgccuccaac     1860

cccucccccc aguacuccug gcgcaucaac ggcauccccc agcagcacac ccagguccuc     1920

uucaucgcca agaucacccc caacaacaac ggcaccuacg ccugcuucgu cuccaaccuc     1980

gccaccggcc gcaacaacuc caucgucaag uccaucaccg ucuccgccuc cggcaccucc     2040

cccggccucu ccgccggcgc caccgucggc aucaugaucg gcguccucgu cggcgucgcc     2100

cucaucuga                                                             2109


<210>  1060
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CEA__Homo_sapiens__CCDS12584.1

<400>  1060
auggagagcc ccuccgcccc uccacacaga uggugcaucc cguggcagag gcugcuccuu       60

accgcuucuc uguugacauu cuggaauccc ccuacuacgg caaaguuaac cauugaauca      120

acaccauuua auguggccga gggcaaagaa guccugcuac ucguucauaa ccugccccaa      180

caccuuuucg gguacaguug guauaaggga gagcgggugg acgguaaucg ccagauaauc      240

ggcuacguaa uugggacuca gcaggcgacc ccuggaccag cuuauagcgg ccgagaaauc      300

auuuacccca acgccucccu guugauccaa aauauaaucc agaacgauac agguuuuuau      360

acccuccaug ugauuaaauc ugaccugguc aaugaggagg caacugggca guuccgugug      420

uacccugaac ugccaaagcc gucgaucuca agcaacaaua guaaacccgu ugaggauaag      480

gacgccgugg cuuuuacaug ugaaccugag acccaggaug caacguaucu cugguggguc      540

aacaaucaau ccuuaccagu gucucccaga cugcagcuua gcaacggaaa uaggacuuug      600

acccuguuca acguaacacg gaaugacacu gccuccuaca agugcgagac ccagaacccu      660

guuucagcuc gcagaaguga uagcgugauu cuaaacgucc ucuacggccc agacgccccc      720

acaaucucuc cgcugaauac cuccuauagg ucaggcgaaa accuuaaucu gagcugucac      780

gcggcaagua acccucccgc ccaguacucu ugguuuguga augggacguu ccaacagucc      840

acucaggagu uguuuauacc aaacauuaca gugaauaaca gcggaucgua uaccugccaa      900

gcucauaauu cugauacugg ucucaaccgg acaaccguca cgaccaucac aguuuacgcc      960

gaaccuccca aaccauucau uacuuccaau aacucaaauc ccguggagga cgaagaugca     1020

guagcucuga ccugugagcc ugagauccag aacacaacuu auuuauggug ggugaauaac     1080

cagagucugc cagucagccc gcgccuccag cuuuccaacg acaaucgaac ccugacauug     1140

cuaucuguga ccagaaacga uguuggcccc uacgaaugcg ggauccaaaa ugagcugagc     1200

guggaccacu cagacccugu cauucucaac gugcuguaug gaccagauga ccccacuaua     1260

aguccuuccu acacguacua uaggccaggc guaaaucuua gccugucuug ucacgccgcg     1320

ucaaaucccc cggcccagua caguugguug aucgauggua auauucagca gcauacacaa     1380

gaacucuuua ucagcaacau aaccgagaag aacuccgggc uguauacuug ccaggcaaac     1440

aauucugcuu cgggacacag ccggaccaca guuaaaacca uuacuguguc cgccgaauua     1500

ccuaagccau caaucaguuc uaacaauagc aaacccgucg aggacaagga ugcuguggcc     1560

uucacaugug agccugaagc acagaacacg accuaccugu ggugggucaa uggccagucc     1620

cuacccgugu caccacgucu ccaacugagc aacggcaacc gcacucuuac auuguuuaau     1680

guuaccagaa acgacgccag ggcuuaugug ugcgggaucc agaacucugu auccgcgaac     1740

cggagugauc cugucacacu ggacgugcuc uacggacccg auacuccaau uaucagcccg     1800

ccugacucuu ccuaucuguc aggugcaaau cuuaaccuga guugucauag cgccucgaau     1860

cccuccccac aguacucuug gcgaauuaac ggcauacccc agcaacacac ccagguuuug     1920

uucaucgcua agauuacgcc uaauaacaau gggaccuacg ccugcuucgu gagcaaccuc     1980

gcaacaggac gcaauaacuc aaucgucaaa aguaucacug uguccgccuc uggcaccagc     2040

ccaggucugu ccgcuggggc cacaguaggc auuaugauag gaguguuagu uggcgucgca     2100

cugaucuga                                                             2109


<210>  1061
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CEA__Homo_sapiens__CCDS12584.1

<400>  1061
auggagagcc ccagcgcccc cccccacaga uggugcaucc ccuggcagag acugcugcug       60

accgccagcc ugcugaccuu cuggaacccc cccaccaccg ccaagcugac caucgagagc      120

acccccuuca acguggccga gggcaaggag gugcugcugc uggugcacaa ccugccccag      180

caccuguucg gcuacagcug guacaagggc gagagagugg acggcaacag acagaucauc      240

ggcuacguga ucggcaccca gcaggccacc cccggccccg ccuacagcgg cagagagauc      300

aucuacccca acgccagccu gcugauccag aacaucaucc agaacgacac cggcuucuac      360

acccugcacg ugaucaagag cgaccuggug aacgaggagg ccaccggcca guucagagug      420

uaccccgagc ugcccaagcc cagcaucagc agcaacaaca gcaagcccgu ggaggacaag      480

gacgccgugg ccuucaccug cgagcccgag acccaggacg ccaccuaccu guggugggug      540

aacaaccaga gccugcccgu gagccccaga cugcagcuga gcaacggcaa cagaacccug      600

acccuguuca acgugaccag aaacgacacc gccagcuaca agugcgagac ccagaacccc      660

gugagcgcca gaagaagcga cagcgugauc cugaacgugc uguacggccc cgacgccccc      720

accaucagcc cccugaacac cagcuacaga agcggcgaga accugaaccu gagcugccac      780

gccgccagca acccccccgc ccaguacagc ugguucguga acggcaccuu ccagcagagc      840

acccaggagc uguucauccc caacaucacc gugaacaaca gcggcagcua caccugccag      900

gcccacaaca gcgacaccgg ccugaacaga accaccguga ccaccaucac cguguacgcc      960

gagcccccca agcccuucau caccagcaac aacagcaacc ccguggagga cgaggacgcc     1020

guggcccuga ccugcgagcc cgagauccag aacaccaccu accuguggug ggugaacaac     1080

cagagccugc ccgugagccc cagacugcag cugagcaacg acaacagaac ccugacccug     1140

cugagcguga ccagaaacga cgugggcccc uacgagugcg gcauccagaa cgagcugagc     1200

guggaccaca gcgaccccgu gauccugaac gugcuguacg gccccgacga ccccaccauc     1260

agccccagcu acaccuacua cagacccggc gugaaccuga gccugagcug ccacgccgcc     1320

agcaaccccc ccgcccagua cagcuggcug aucgacggca acauccagca gcacacccag     1380

gagcuguuca ucagcaacau caccgagaag aacagcggcc uguacaccug ccaggccaac     1440

aacagcgcca gcggccacag cagaaccacc gugaagacca ucaccgugag cgccgagcug     1500

cccaagccca gcaucagcag caacaacagc aagcccgugg aggacaagga cgccguggcc     1560

uucaccugcg agcccgaggc ccagaacacc accuaccugu ggugggugaa cggccagagc     1620

cugcccguga gccccagacu gcagcugagc aacggcaaca gaacccugac ccuguucaac     1680

gugaccagaa acgacgccag agccuacgug ugcggcaucc agaacagcgu gagcgccaac     1740

agaagcgacc ccgugacccu ggacgugcug uacggccccg acacccccau caucagcccc     1800

cccgacagca gcuaccugag cggcgccaac cugaaccuga gcugccacag cgccagcaac     1860

cccagccccc aguacagcug gagaaucaac ggcauccccc agcagcacac ccaggugcug     1920

uucaucgcca agaucacccc caacaacaac ggcaccuacg ccugcuucgu gagcaaccug     1980

gccaccggca gaaacaacag caucgugaag agcaucaccg ugagcgccag cggcaccagc     2040

cccggccuga gcgccggcgc caccgugggc aucaugaucg gcgugcuggu gggcguggcc     2100

cugaucuga                                                             2109


<210>  1062
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CEA__Homo_sapiens__CCDS12584.1

<400>  1062
auggagagcc ccuccgcccc uccgcacaga uggugcaucc ccuggcagcg gcugcuccug       60

accgcuucuc uucugacauu cuggaacccu cccacgaccg ccaagcucac aauugaaagc      120

accccuuuua auguggcgga gggcaaagaa guccugcuuc ugguucauaa ccucccccaa      180

caccuguucg gguacuccug guauaaggga gagcgcgugg acggcaauag acagaucauu      240

ggguacguga ucggaacaca gcaggcuacc ccuggcccgg ccuauucugg gcgggaaauu      300

aucuacccca acgccagccu gcucauccaa aauauuaucc agaacgauac aggauuuuau      360

acccugcaug ucauuaaauc cgaccuugug aaugaggagg cuacgggcca guuccgcguu      420

uacccugaac ugcccaagcc uucuaucagc uccaacaaua gcaaacccgu ggaggauaag      480

gacgccgucg cuuuuaccug ugaaccggag acacaggaug ccaccuaucu cuggugggug      540

aacaaucaau cucugccugu uucccccaga cuucagcuga gcaacggcaa ucggacacuc      600

acccuguuca acgugacgcg caaugacaca gcgucuuaca agugcgagac ccagaacccu      660

gucuccgcca gacggagcga uucugugauu cugaacgugc ucuacgggcc cgacgcuccc      720

acaaucuccc cucugaauac cagcuaucgc uccggagaaa accuuaaucu gucuugucac      780

gccgcuagca acccgcccgc ccaguacucc ugguuuguca auggcaccuu ccaacagagc      840

acacaggagc ucuuuauucc uaacaucacg guuaauaacu cuggguccua uaccugccaa      900

gcgcauaaua gcgauacagg acugaacaga accacaguga ccacgaucac aguguacgcc      960

gaacccccua aacccuucau uaccucuaau aacagcaauc cggucgagga cgaagaugcu     1020

guggcccuua ccugugagcc ugagauccag aacacaaccu aucuguggug gguuaauaac     1080

cagucccucc ccgugucucc ucggcugcag cugagcaacg acaaucgcac acucacgcug     1140

cuuuccguca ccagaaacga ugugggcccc uacgaaugcg ggauucaaaa ugagcugagc     1200

guugaccacu cugacccugu gauccucaac guccuguaug gacccgauga cccgacaauu     1260

uccccuagcu acaccuacua ucggcccggc gugaaucuuu cucuguccug ucacgcugcc     1320

agcaaucccc cugcccagua cuccuggcuc aucgauggca auauccagca gcauacacaa     1380

gaacuguuua uuucuaacau caccgagaag aauagcgggc uguauacgug ccaggcuaac     1440

aauuccgcgu cuggacacag ccgcaccaca gucaaaacca uuacaguguc cgccgaacuc     1500

ccgaagccca gcaucucuuc caacaauagc aaaccuguug aggacaagga ugcuguggcc     1560

uucaccugug agcccgaagc ccagaacacg acauaccugu ggugggucaa uggccagucu     1620

cuuccugugu cccccagacu gcaacucagc aacgggaacc ggacccugac acuguuuaau     1680

guuaccagaa acgacgcucg cgccuaugug ugcggcauuc agaacucugu cagcgcgaac     1740

cgguccgauc cugugacccu ugacgugcuc uacggacccg auacaccgau caucagcccu     1800

cccgacucuu ccuaucugag cggggcuaau cugaaccucu ccugucauuc ugccagcaau     1860

ccuucucccc aguacuccug gagaauuaac ggaaucccgc agcaacacac gcagguucug     1920

uucauugcca agaucacccc uaauaacaau ggcacauacg cuugcuucgu cagcaaccuu     1980

gccaccggcc gcaauaacuc cauugugaaa ucuaucacag ugagcgcuuc cgggaccagc     2040

cccggacugu cugccggcgc gacggucggg auuaugaucg gagugcucgu uggcguggcc     2100

cugaucuga                                                             2109


<210>  1063
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CEAM6__Homo_sapiens__P40199

<400>  1063

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  1064
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CEAM6__Homo_sapiens__AAA51739

<400>  1064
augggacccc ccucagcccc ucccugcaga uugcaugucc ccuggaagga gguccugcuc       60

acagccucac uucuaaccuu cuggaaccca cccaccacug ccaagcucac uauugaaucc      120

acgccauuca augucgcaga ggggaaggag guucuucuac ucgcccacaa ccugccccag      180

aaucguauug guuacagcug guacaaaggc gaaagagugg auggcaacag ucuaauugua      240

ggauauguaa uaggaacuca acaagcuacc ccagggcccg cauacagugg ucgagagaca      300

auauacccca augcaucccu gcugauccag aacgucaccc agaaugacac aggauucuau      360

acccuacaag ucauaaaguc agaucuugug aaugaagaag caaccggaca guuccaugua      420

uacccggagc ugcccaagcc cuccaucucc agcaacaacu ccaaccccgu ggaggacaag      480

gaugcugugg ccuucaccug ugaaccugag guucagaaca caaccuaccu guggugggua      540

aauggucaga gccucccggu cagucccagg cugcagcugu ccaauggcaa caugacccuc      600

acucuacuca gcgucaaaag gaacgaugca ggauccuaug aaugugaaau acagaaccca      660

gcgagugcca accgcaguga cccagucacc cugaaugucc ucuauggccc agauggcccc      720

accauuuccc ccucaaaggc caauuaccgu ccaggggaaa aucugaaccu cuccugccac      780

gcagccucua acccaccugc acaguacucu ugguuuauca augggacguu ccagcaaucc      840

acacaagagc ucuuuauccc caacaucacu gugaauaaua gcggauccua uaugugccaa      900

gcccauaacu cagccacugg ccucaauagg accacaguca cgaugaucac agucucugga      960

agugcuccug uccucucagc uguggccacc gucggcauca cgauuggagu gcuggccagg     1020

gucgcucuga uauag                                                      1035


<210>  1065
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CEAM6__Homo_sapiens__AAA51739

<400>  1065
auggggcccc cgagcgcccc gcccugccgc cugcacgugc ccuggaagga gguccuccug       60

accgccuccc ugcucaccuu cuggaacccg cccacgaccg cgaagcugac caucgagagc      120

acccccuuca acguggccga gggcaaggag gugcugcucc uggcccacaa ccugccccag      180

aaccggaucg gcuacuccug guacaagggg gagcgcgucg acggcaacag ccucaucgug      240

ggguacguga ucggcacgca gcaggccacc cccggccccg ccuacuccgg gcgggagacc      300

aucuacccca acgcgagccu gcugauccag aacgucaccc agaacgacac gggcuucuac      360

acccuccagg ugaucaaguc cgaccuggug aacgaggagg ccaccgggca guuccacguc      420

uaccccgagc ugccgaagcc cagcaucucc agcaacaacu ccaaccccgu ggaggacaag      480

gacgccgugg ccuucacgug cgagcccgag guccagaaca ccaccuaccu cuggugggug      540

aacggccaga gccugccggu gagcccccgc cugcagcucu ccaacgggaa caugacccug      600

acccugcucu ccgucaagcg gaacgacgcg ggcagcuacg agugcgagau ccagaacccc      660

gccuccgcca accgcagcga ccccgugacg cugaacgugc uguacggccc ggacgggccc      720

accaucuccc ccagcaaggc caacuaccgg cccggcgaga accucaaccu gagcugccac      780

gccgcgucca acccgcccgc ccaguacagc ugguucauca acgggaccuu ccagcagucc      840

acccaggagc uguucauccc caacaucacg gucaacaaca gcggcuccua caugugccag      900

gcccacaaca gcgccaccgg ccucaaccgc accaccguga cgaugaucac cguguccggg      960

agcgcccccg uccuguccgc gguggccacc gugggcauca ccaucggggu ccuggcccgg     1020

guggcccuca ucuga                                                      1035


<210>  1066
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CEAM6__Homo_sapiens__AAA51739

<400>  1066
augggccccc ccuccgcccc ccccugccgc cuccacgucc ccuggaagga gguccuccuc       60

accgccuccc uccucaccuu cuggaacccc cccaccaccg ccaagcucac caucgagucc      120

acccccuuca acgucgccga gggcaaggag guccuccucc ucgcccacaa ccucccccag      180

aaccgcaucg gcuacuccug guacaagggc gagcgcgucg acggcaacuc ccucaucguc      240

ggcuacguca ucggcaccca gcaggccacc cccggccccg ccuacuccgg ccgcgagacc      300

aucuacccca acgccucccu ccucauccag aacgucaccc agaacgacac cggcuucuac      360

acccuccagg ucaucaaguc cgaccucguc aacgaggagg ccaccggcca guuccacguc      420

uaccccgagc uccccaagcc cuccaucucc uccaacaacu ccaaccccgu cgaggacaag      480

gacgccgucg ccuucaccug cgagcccgag guccagaaca ccaccuaccu cugguggguc      540

aacggccagu cccuccccgu cuccccccgc cuccagcucu ccaacggcaa caugacccuc      600

acccuccucu ccgucaagcg caacgacgcc ggcuccuacg agugcgagau ccagaacccc      660

gccuccgcca accgcuccga ccccgucacc cucaacgucc ucuacggccc cgacggcccc      720

accaucuccc ccuccaaggc caacuaccgc cccggcgaga accucaaccu cuccugccac      780

gccgccucca acccccccgc ccaguacucc ugguucauca acggcaccuu ccagcagucc      840

acccaggagc ucuucauccc caacaucacc gucaacaacu ccggcuccua caugugccag      900

gcccacaacu ccgccaccgg ccucaaccgc accaccguca ccaugaucac cgucuccggc      960

uccgcccccg uccucuccgc cgucgccacc gucggcauca ccaucggcgu ccucgcccgc     1020

gucgcccuca ucuga                                                      1035


<210>  1067
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CEAM6__Homo_sapiens__AAA51739

<400>  1067
auggggcccc cuagcgcccc accgugcaga cugcacgugc ccuggaagga gguccuccuu       60

accgcuuccc uguugacauu cuggaacccu ccaacuacgg caaaauuaac caucgaaucu      120

acacccuuua auguugccga gggcaaggaa gugcugcuac ucgcgcauaa ccugccucag      180

aauaggauug gauacucaug guauaaaggu gagcggguag acggcaacag ucuuauagug      240

ggguacguca ucggaacuca acaggcuacc ccaggccccg ccuauagcgg ucgcgaaaca      300

auuuacccua augcaucccu guugauccag aacgugaccc agaaugauac uggguucuau      360

acacuccaag uuauuaaguc ugaccuggug aacgaggagg ccaccggaca guuucacguc      420

uacccagaac ugccgaaacc cucgaucuca agcaauaaca guaauccugu ggaggauaag      480

gacgcuguag cauucacgug ugaaccagag guucagaaca cuaccuaucu cuggugggug      540

aauggccagu ccuuacccgu cucuccucga cugcaacuua gcaacggcaa uaugacauug      600

acucugcuau ccgugaagcg uaacgaugcc gggucauacg agugcgaaau acagaaccca      660

gcuagugcca auagaagcga ccccgugacc cucaacgucc uguacggacc ggaugguccu      720

acaaucucuc ccuccaaagc gaauuauagg ccaggcgaga accuuaaucu gucaugucau      780

gcagccagca acccucccgc ucaguacagu ugguuuauua augggaccuu ccagcaaucu      840

acgcaggaau uguuuauccc aaacauuacu guuaauaacu ccggaagcua uaugugccag      900

gcccacaauu cggcaacagg ccucaaccgg accacuguga caaugaucac cguaucuggu      960

uccgcucccg ugcugucagc cgucgcgacg guggggauaa ccauuggagu uuuagcccgc     1020

guggcacuga ucuga                                                      1035


<210>  1068
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CEAM6__Homo_sapiens__AAA51739

<400>  1068
augggccccc ccagcgcccc ccccugcaga cugcacgugc ccuggaagga ggugcugcug       60

accgccagcc ugcugaccuu cuggaacccc cccaccaccg ccaagcugac caucgagagc      120

acccccuuca acguggccga gggcaaggag gugcugcugc uggcccacaa ccugccccag      180

aacagaaucg gcuacagcug guacaagggc gagagagugg acggcaacag ccugaucgug      240

ggcuacguga ucggcaccca gcaggccacc cccggccccg ccuacagcgg cagagagacc      300

aucuacccca acgccagccu gcugauccag aacgugaccc agaacgacac cggcuucuac      360

acccugcagg ugaucaagag cgaccuggug aacgaggagg ccaccggcca guuccacgug      420

uaccccgagc ugcccaagcc cagcaucagc agcaacaaca gcaaccccgu ggaggacaag      480

gacgccgugg ccuucaccug cgagcccgag gugcagaaca ccaccuaccu guggugggug      540

aacggccaga gccugcccgu gagccccaga cugcagcuga gcaacggcaa caugacccug      600

acccugcuga gcgugaagag aaacgacgcc ggcagcuacg agugcgagau ccagaacccc      660

gccagcgcca acagaagcga ccccgugacc cugaacgugc uguacggccc cgacggcccc      720

accaucagcc ccagcaaggc caacuacaga cccggcgaga accugaaccu gagcugccac      780

gccgccagca acccccccgc ccaguacagc ugguucauca acggcaccuu ccagcagagc      840

acccaggagc uguucauccc caacaucacc gugaacaaca gcggcagcua caugugccag      900

gcccacaaca gcgccaccgg ccugaacaga accaccguga ccaugaucac cgugagcggc      960

agcgcccccg ugcugagcgc cguggccacc gugggcauca ccaucggcgu gcuggccaga     1020

guggcccuga ucuga                                                      1035


<210>  1069
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CEAM6__Homo_sapiens__AAA51739

<400>  1069
auggggcccc cuagcgcccc gcccugcaga cugcacgugc cuuggaagga gguccuccug       60

accgcuuccc uucugacauu cuggaauccc ccuacgaccg ccaaacucac aaucgaaucu      120

acccccuuua acguugcgga gggcaaggaa gugcugcuuc uggcucauaa ccucccucag      180

aaucggauug gauacagcug guauaaaggc gagcgcgugg acgggaacuc ccugaucguc      240

ggauacguga uuggcacaca acaggccacc ccggggcccg ccuauucugg aagagaaaca      300

aucuacccua augcuagccu gcucauucag aacguuaccc agaaugauac gggcuucuau      360

acccugcaag ugaucaaguc cgaccuuguc aacgaggagg ccacaggcca guuucacgug      420

uaccccgaac ugccuaaacc cucuaucagc uccaauaaca gcaauccggu ugaggauaag      480

gacgcugugg ccuucaccug ugaaccugag guccagaaca caaccuaucu cuggugggug      540

aaugggcagu cucugcccgu guccccucgg cuucaacuga gcaacggaaa uaugacgcuc      600

acacugcugu cugucaagcg caacgaugcg ggcuccuacg agugcgaaau ucagaacccc      660

gccagcgcua auagaucuga ccccguuacc cucaacgugc uguacgggcc ugauggaccg      720

acaaucuccc ccagcaaagc caauuaucgg ccuggcgaga accuuaaucu guccugucau      780

gcugccucua aucccccugc gcaguacagc ugguuuauua acgggaccuu ccagcaaucc      840

acccaggaac ucuuuauccc caacauuaca gugaauaaca gcggaucuua uaugugccag      900

gcccacaauu ccgcuacggg ccugaaccgc accacaguca ccaugaucac agugagcggc      960

ucugccccgg uucuuagcgc uguggccacc gucgggauua cgaucggagu gcuggccaga     1020

guugcucuca ucuga                                                      1035


<210>  1070
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CH3L2__Homo_sapiens__Q15782

<400>  1070

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr 
    210                 215                 220                 


Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser 
225                 230                 235                 240 


Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys Gly 
                245                 250                 255     


Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His Ser 
            260                 265                 270         


Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser Gly 
        275                 280                 285             


Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala Tyr 
    290                 295                 300                 


Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
305                 310                 315                 320 


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
                325                 330                 335     


Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn Leu 
            340                 345                 350         


Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe Thr 
        355                 360                 365             


Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val Lys 
    370                 375                 380                 


Arg Ser Leu Gly Ser Leu 
385                 390 


<210>  1071
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CH3L2__Homo_sapiens__AAB04533

<400>  1071
augggagcaa ccaccaugga ccagaagucu cucugggcag guguaguggu cuugcugcuu       60

cuccagggag gaucugccua caaacugguu ugcuacuuua ccaacugguc ccaggaccgg      120

caggaaccag gaaaauucac cccugagaau auugaccccu uccuaugcuc ucaucucauc      180

uauucauucg ccagcaucga aaacaacaag guuaucauca aggacaagag ugaagugaug      240

cucuaccaga ccaucaacag ucucaaaacc aagaauccca aacugaaaau ucucuugucc      300

auuggagggu accuguuugg uuccaaaggg uuccacccua ugguggauuc uucuacauca      360

cgcuuggaau ucauuaacuc cauaauccug uuucugagga accauaacuu ugauggacug      420

gauguaagcu ggaucuaccc agaucagaaa gaaaacacuc auuucacugu gcugauucau      480

gaguuagcag aagccuuuca gaaggacuuc acaaaaucca ccaaggaaag gcuucucuug      540

acugcgggcg uaucugcagg gaggcaaaug auugauaaca gcuaucaagu ugagaaacug      600

gcaaaagauc uggauuucau caaccuccug uccuuugacu uccauggguc uugggaaaag      660

ccccuuauca cuggccacaa cagcccucug agcaaggggu ggcaggacag agggccaagc      720

uccuacuaca auguggaaua ugcugugggg uacuggauac auaagggaau gccaucagag      780

aaggugguca ugggcauccc cacauauggg cacuccuuca cacuggccuc ugcagaaacc      840

accguggggg ccccugccuc uggcccugga gcugcuggac ccaucacaga gucuucaggc      900

uuccuggccu auuaugagau cugccaguuc cugaaaggag ccaagaucac gcggcuccag      960

gaucagcagg uucccuacgc agucaagggg aaccaguggg ugggcuauga ugaugugaag     1020

aguauggaga ccaagguuca guucuuaaag aauuuaaacc ugggaggagc caugaucugg     1080

ucuauugaca uggaugacuu cacuggcaaa uccugcaacc agggcccuua cccucuuguc     1140

caagcaguca agagaagccu uggcucccug uga                                  1173


<210>  1072
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CH3L2__Homo_sapiens__AAB04533

<400>  1072
augggcgcca ccaccaugga ccagaagucc cugugggccg ggguggucgu gcuccugcug       60

cuccagggcg ggagcgcgua caagcuggug ugcuacuuca cgaacuggag ccaggaccgc      120

caggagcccg gcaaguucac cccggagaac aucgaccccu uccugugcuc ccaccucauc      180

uacagcuucg ccuccaucga gaacaacaag gucaucauca aggacaagag cgaggugaug      240

cuguaccaga ccaucaacuc ccugaagacc aagaacccca agcucaagau ccugcugagc      300

aucgggggcu accucuucgg cuccaagggg uuccacccca ugguggacag cuccacgagc      360

cggcuggagu ucaucaacuc caucauccug uuccuccgca accacaacuu cgacggccug      420

gacgucagcu ggaucuaccc ggaccagaag gagaacaccc acuucaccgu gcugauccac      480

gagcucgccg aggccuucca gaaggacuuc accaagucca cgaaggagcg gcugcugcuc      540

accgccgggg ugagcgcggg ccgccagaug aucgacaacu ccuaccaggu cgagaagcug      600

gccaaggacc uggacuucau caaccuccug agcuucgacu uccacggguc cugggagaag      660

ccccugauca ccggccacaa cagcccccuc agcaagggcu ggcaggaccg ggggcccucc      720

agcuacuaca acguggagua cgccgugggc uacuggaucc acaaggggau gccguccgag      780

aaggucguga ugggcauccc caccuacggc cacagcuuca cgcuggccuc cgcggagacc      840

accguggggg cccccgccag cggccccggg gccgccggcc cgaucaccga guccagcggg      900

uuccuggcgu acuacgagau cugccaguuc cucaagggcg ccaagaucac gcgccugcag      960

gaccagcagg uccccuacgc cgugaagggc aaccaguggg ugggguacga cgacgucaag     1020

uccauggaga ccaaggugca guuccugaag aaccucaacc ugggcggggc caugaucugg     1080

agcaucgaca uggacgacuu caccggcaag uccugcaacc aggggcccua cccccuggug     1140

caggccguca agcggagccu cggcucccug uga                                  1173


<210>  1073
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CH3L2__Homo_sapiens__AAB04533

<400>  1073
augggcgcca ccaccaugga ccagaagucc cucugggccg gcgucgucgu ccuccuccuc       60

cuccagggcg gcuccgccua caagcucguc ugcuacuuca ccaacugguc ccaggaccgc      120

caggagcccg gcaaguucac ccccgagaac aucgaccccu uccucugcuc ccaccucauc      180

uacuccuucg ccuccaucga gaacaacaag gucaucauca aggacaaguc cgaggucaug      240

cucuaccaga ccaucaacuc ccucaagacc aagaacccca agcucaagau ccuccucucc      300

aucggcggcu accucuucgg cuccaagggc uuccacccca uggucgacuc cuccaccucc      360

cgccucgagu ucaucaacuc caucauccuc uuccuccgca accacaacuu cgacggccuc      420

gacgucuccu ggaucuaccc cgaccagaag gagaacaccc acuucaccgu ccucauccac      480

gagcucgccg aggccuucca gaaggacuuc accaagucca ccaaggagcg ccuccuccuc      540

accgccggcg ucuccgccgg ccgccagaug aucgacaacu ccuaccaggu cgagaagcuc      600

gccaaggacc ucgacuucau caaccuccuc uccuucgacu uccacggcuc cugggagaag      660

ccccucauca ccggccacaa cuccccccuc uccaagggcu ggcaggaccg cggccccucc      720

uccuacuaca acgucgagua cgccgucggc uacuggaucc acaagggcau gcccuccgag      780

aaggucguca ugggcauccc caccuacggc cacuccuuca cccucgccuc cgccgagacc      840

accgucggcg cccccgccuc cggccccggc gccgccggcc ccaucaccga guccuccggc      900

uuccucgccu acuacgagau cugccaguuc cucaagggcg ccaagaucac ccgccuccag      960

gaccagcagg uccccuacgc cgucaagggc aaccaguggg ucggcuacga cgacgucaag     1020

uccauggaga ccaaggucca guuccucaag aaccucaacc ucggcggcgc caugaucugg     1080

uccaucgaca uggacgacuu caccggcaag uccugcaacc agggccccua cccccucguc     1140

caggccguca agcgcucccu cggcucccuc uga                                  1173


<210>  1074
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CH3L2__Homo_sapiens__AAB04533

<400>  1074
augggcgcca ccacaaugga ccaaaagagc cugugggcug ggguggucgu ucuccuucug       60

uugcagggag guuccgcaua caaauuagug ugcuauuuca cuaacugguc ucaggauaga      120

caggagcccg gcaaguuuac gccugaaaau aucgacccau uccuguguuc acaccuaauu      180

uacaguuuug ccagcauaga gaacaauaaa guaaucauua aggauaaauc cgaagugaug      240

cucuaucaga ccaucaacuc ucugaagaca aagaauccga aacuuaagau ucuguugucg      300

aucgggggau accucuucgg cucaaaaggu uuucauccca uggucgacag caguacuucc      360

aggcuggagu ucauaaacuc uaucauucug uuucuccgga aucacaacuu cgauggguua      420

gacgugagcu ggaucuaucc ugaucaaaag gaaaauaccc auuuuacagu ucugauucac      480

gagcuugcgg aggcuuucca gaaagacuuu accaagucca cuaaggaacg cuugcugcua      540

acagccggag ugucagcagg ccgacagaug aucgauaaca guuaccaggu cgagaaacuc      600

gccaaggacc uggauuucau aaaucuucug agcuuugacu uccauggcuc uugggaaaaa      660

ccauugauua ccgggcacaa cuccccacuc ucaaagggau ggcaagaucg ugguccuagc      720

aguuauuaca auguggagua cgcuguaggc uauuggaucc acaaagggau gccaucugag      780

aagguuguga ugggcauucc cacguacgga cauuccuuca cucuggcaag cgccgaaacc      840

acagucggug cuccugccuc ggggccagga gcggcaggcc cgaucacuga gucuuccggc      900

uuuuuagccu auuacgaaau cugccaguuc cugaaagggg cuaagauuac cagacuccag      960

gaccagcaag ugcccuaugc cgugaaggga aaccaguggg ucgguuacga cgauguuaaa     1020

ucaauggaga caaaggugca guuucuuaaa aaucugaacu ugggcggggc aaugauaugg     1080

aguaucgaca uggaugacuu caccggaaag agcuguaacc aaggcccuua uccccuagua     1140

caggcuguga aaaggucccu ggguucucuc uga                                  1173


<210>  1075
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CH3L2__Homo_sapiens__AAB04533

<400>  1075
augggcgcca ccaccaugga ccagaagagc cugugggccg gcgugguggu gcugcugcug       60

cugcagggcg gcagcgccua caagcuggug ugcuacuuca ccaacuggag ccaggacaga      120

caggagcccg gcaaguucac ccccgagaac aucgaccccu uccugugcag ccaccugauc      180

uacagcuucg ccagcaucga gaacaacaag gugaucauca aggacaagag cgaggugaug      240

cuguaccaga ccaucaacag ccugaagacc aagaacccca agcugaagau ccugcugagc      300

aucggcggcu accuguucgg cagcaagggc uuccacccca ugguggacag cagcaccagc      360

agacuggagu ucaucaacag caucauccug uuccugagaa accacaacuu cgacggccug      420

gacgugagcu ggaucuaccc cgaccagaag gagaacaccc acuucaccgu gcugauccac      480

gagcuggccg aggccuucca gaaggacuuc accaagagca ccaaggagag acugcugcug      540

accgccggcg ugagcgccgg cagacagaug aucgacaaca gcuaccaggu ggagaagcug      600

gccaaggacc uggacuucau caaccugcug agcuucgacu uccacggcag cugggagaag      660

ccccugauca ccggccacaa cagcccccug agcaagggcu ggcaggacag aggccccagc      720

agcuacuaca acguggagua cgccgugggc uacuggaucc acaagggcau gcccagcgag      780

aaggugguga ugggcauccc caccuacggc cacagcuuca cccuggccag cgccgagacc      840

accgugggcg cccccgccag cggccccggc gccgccggcc ccaucaccga gagcagcggc      900

uuccuggccu acuacgagau cugccaguuc cugaagggcg ccaagaucac cagacugcag      960

gaccagcagg ugcccuacgc cgugaagggc aaccaguggg ugggcuacga cgacgugaag     1020

agcauggaga ccaaggugca guuccugaag aaccugaacc ugggcggcgc caugaucugg     1080

agcaucgaca uggacgacuu caccggcaag agcugcaacc agggccccua cccccuggug     1140

caggccguga agagaagccu gggcagccug uga                                  1173


<210>  1076
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CH3L2__Homo_sapiens__AAB04533

<400>  1076
augggcgcca ccacaaugga ccaaaagagc cugugggcug ggguggucgu ucuccugcuu       60

cugcagggag gcuccgccua caaacucgug ugcuauuuca cgaacugguc ucaggauaga      120

caggagcccg ggaaguuuac cccugaaaau aucgacccgu uccuguguag ccaccuuauu      180

uacuccuuug cgucuaucga gaacaauaaa gugauuauca aggauaaaag cgaagucaug      240

cuguaucaga caauuaacuc ccucaagacc aagaauccca aacugaagau ccugcucucu      300

aucggaggcu accuguucgg gagcaaagga uuucauccua ugguggacuc cagcacaucu      360

cggcuugagu ucauuaacuc caucauucug uuucuccgca aucacaacuu cgauggccug      420

gacguuagcu ggaucuaucc cgaucaaaag gaaaauaccc auuuuacagu gcuuauucac      480

gagcuggcug aggccuucca gaaagacuuu accaagucua cgaaggaaag acuccugcug      540

accgccggcg ucuccgcugg gcggcagaug aucgauaaca gcuaccaggu ggagaaacuc      600

gccaaggacc uggauuucau uaaucuucug ucuuuugacu uccauggauc cugggaaaaa      660

ccucucauca caggccacaa cagcccccug uccaaggggu ggcaagaucg cggaccuucu      720

agcuauuaca auguugagua cgcugugggc uauuggaucc acaaagggau gccguccgag      780

aaggucguga ugggcauucc caccuacgga cauagcuuca cacuugccuc ugcggaaacc      840

acggugggcg ccccugcuuc cgggcccgga gccgcuggcc cuaucacaga gagcucuggg      900

uuucuggccu auuacgaaau uugccaguuc cucaaaggag cgaagaucac cagacugcag      960

gaccagcaag uccccuaugc cguuaagggc aaccaguggg ugggguacga cgaugugaaa     1020

agcauggaga caaaggucca guuucugaaa aaucucaacc ugggaggcgc uaugauuugg     1080

uccaucgaca uggaugacuu caccggcaag ucuuguaacc aagggccgua uccucuugug     1140

caggccguua aacggagccu gggaucccuc uga                                  1173


<210>  1077
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CLCA2__Homo_sapiens__Q9UQC9

<400>  1077

Met Thr Gln Arg Ser Ile Ala Gly Pro Ile Cys Asn Leu Lys Phe Val 
1               5                   10                  15      


Thr Leu Leu Val Ala Leu Ser Ser Glu Leu Pro Phe Leu Gly Ala Gly 
            20                  25                  30          


Val Gln Leu Gln Asp Asn Gly Tyr Asn Gly Leu Leu Ile Ala Ile Asn 
        35                  40                  45              


Pro Gln Val Pro Glu Asn Gln Asn Leu Ile Ser Asn Ile Lys Glu Met 
    50                  55                  60                  


Ile Thr Glu Ala Ser Phe Tyr Leu Phe Asn Ala Thr Lys Arg Arg Val 
65                  70                  75                  80  


Phe Phe Arg Asn Ile Lys Ile Leu Ile Pro Ala Thr Trp Lys Ala Asn 
                85                  90                  95      


Asn Asn Ser Lys Ile Lys Gln Glu Ser Tyr Glu Lys Ala Asn Val Ile 
            100                 105                 110         


Val Thr Asp Trp Tyr Gly Ala His Gly Asp Asp Pro Tyr Thr Leu Gln 
        115                 120                 125             


Tyr Arg Gly Cys Gly Lys Glu Gly Lys Tyr Ile His Phe Thr Pro Asn 
    130                 135                 140                 


Phe Leu Leu Asn Asp Asn Leu Thr Ala Gly Tyr Gly Ser Arg Gly Arg 
145                 150                 155                 160 


Val Phe Val His Glu Trp Ala His Leu Arg Trp Gly Val Phe Asp Glu 
                165                 170                 175     


Tyr Asn Asn Asp Lys Pro Phe Tyr Ile Asn Gly Gln Asn Gln Ile Lys 
            180                 185                 190         


Val Thr Arg Cys Ser Ser Asp Ile Thr Gly Ile Phe Val Cys Glu Lys 
        195                 200                 205             


Gly Pro Cys Pro Gln Glu Asn Cys Ile Ile Ser Lys Leu Phe Lys Glu 
    210                 215                 220                 


Gly Cys Thr Phe Ile Tyr Asn Ser Thr Gln Asn Ala Thr Ala Ser Ile 
225                 230                 235                 240 


Met Phe Met Gln Ser Leu Ser Ser Val Val Glu Phe Cys Asn Ala Ser 
                245                 250                 255     


Thr His Asn Gln Glu Ala Pro Asn Leu Gln Asn Gln Met Cys Ser Leu 
            260                 265                 270         


Arg Ser Ala Trp Asp Val Ile Thr Asp Ser Ala Asp Phe His His Ser 
        275                 280                 285             


Phe Pro Met Asn Gly Thr Glu Leu Pro Pro Pro Pro Thr Phe Ser Leu 
    290                 295                 300                 


Val Gln Ala Gly Asp Lys Val Val Cys Leu Val Leu Asp Val Ser Ser 
305                 310                 315                 320 


Lys Met Ala Glu Ala Asp Arg Leu Leu Gln Leu Gln Gln Ala Ala Glu 
                325                 330                 335     


Phe Tyr Leu Met Gln Ile Val Glu Ile His Thr Phe Val Gly Ile Ala 
            340                 345                 350         


Ser Phe Asp Ser Lys Gly Glu Ile Arg Ala Gln Leu His Gln Ile Asn 
        355                 360                 365             


Ser Asn Asp Asp Arg Lys Leu Leu Val Ser Tyr Leu Pro Thr Thr Val 
    370                 375                 380                 


Ser Ala Lys Thr Asp Ile Ser Ile Cys Ser Gly Leu Lys Lys Gly Phe 
385                 390                 395                 400 


Glu Val Val Glu Lys Leu Asn Gly Lys Ala Tyr Gly Ser Val Met Ile 
                405                 410                 415     


Leu Val Thr Ser Gly Asp Asp Lys Leu Leu Gly Asn Cys Leu Pro Thr 
            420                 425                 430         


Val Leu Ser Ser Gly Ser Thr Ile His Ser Ile Ala Leu Gly Ser Ser 
        435                 440                 445             


Ala Ala Pro Asn Leu Glu Glu Leu Ser Arg Leu Thr Gly Gly Leu Lys 
    450                 455                 460                 


Phe Phe Val Pro Asp Ile Ser Asn Ser Asn Ser Met Ile Asp Ala Phe 
465                 470                 475                 480 


Ser Arg Ile Ser Ser Gly Thr Gly Asp Ile Phe Gln Gln His Ile Gln 
                485                 490                 495     


Leu Glu Ser Thr Gly Glu Asn Val Lys Pro His His Gln Leu Lys Asn 
            500                 505                 510         


Thr Val Thr Val Asp Asn Thr Val Gly Asn Asp Thr Met Phe Leu Val 
        515                 520                 525             


Thr Trp Gln Ala Ser Gly Pro Pro Glu Ile Ile Leu Phe Asp Pro Asp 
    530                 535                 540                 


Gly Arg Lys Tyr Tyr Thr Asn Asn Phe Ile Thr Asn Leu Thr Phe Arg 
545                 550                 555                 560 


Thr Ala Ser Leu Trp Ile Pro Gly Thr Ala Lys Pro Gly His Trp Thr 
                565                 570                 575     


Tyr Thr Leu Asn Asn Thr His His Ser Leu Gln Ala Leu Lys Val Thr 
            580                 585                 590         


Val Thr Ser Arg Ala Ser Asn Ser Ala Val Pro Pro Ala Thr Val Glu 
        595                 600                 605             


Ala Phe Val Glu Arg Asp Ser Leu His Phe Pro His Pro Val Met Ile 
    610                 615                 620                 


Tyr Ala Asn Val Lys Gln Gly Phe Tyr Pro Ile Leu Asn Ala Thr Val 
625                 630                 635                 640 


Thr Ala Thr Val Glu Pro Glu Thr Gly Asp Pro Val Thr Leu Arg Leu 
                645                 650                 655     


Leu Asp Asp Gly Ala Gly Ala Asp Val Ile Lys Asn Asp Gly Ile Tyr 
            660                 665                 670         


Ser Arg Tyr Phe Phe Ser Phe Ala Ala Asn Gly Arg Tyr Ser Leu Lys 
        675                 680                 685             


Val His Val Asn His Ser Pro Ser Ile Ser Thr Pro Ala His Ser Ile 
    690                 695                 700                 


Pro Gly Ser His Ala Met Tyr Val Pro Gly Tyr Thr Ala Asn Gly Asn 
705                 710                 715                 720 


Ile Gln Met Asn Ala Pro Arg Lys Ser Val Gly Arg Asn Glu Glu Glu 
                725                 730                 735     


Arg Lys Trp Gly Phe Ser Arg Val Ser Ser Gly Gly Ser Phe Ser Val 
            740                 745                 750         


Leu Gly Val Pro Ala Gly Pro His Pro Asp Val Phe Pro Pro Cys Lys 
        755                 760                 765             


Ile Ile Asp Leu Glu Ala Val Lys Val Glu Glu Glu Leu Thr Leu Ser 
    770                 775                 780                 


Trp Thr Ala Pro Gly Glu Asp Phe Asp Gln Gly Gln Ala Thr Ser Tyr 
785                 790                 795                 800 


Glu Ile Arg Met Ser Lys Ser Leu Gln Asn Ile Gln Asp Asp Phe Asn 
                805                 810                 815     


Asn Ala Ile Leu Val Asn Thr Ser Lys Arg Asn Pro Gln Gln Ala Gly 
            820                 825                 830         


Ile Arg Glu Ile Phe Thr Phe Ser Pro Gln Ile Ser Thr Asn Gly Pro 
        835                 840                 845             


Glu His Gln Pro Asn Gly Glu Thr His Glu Ser His Arg Ile Tyr Val 
    850                 855                 860                 


Ala Ile Arg Ala Met Asp Arg Asn Ser Leu Gln Ser Ala Val Ser Asn 
865                 870                 875                 880 


Ile Ala Gln Ala Pro Leu Phe Ile Pro Pro Asn Ser Asp Pro Val Pro 
                885                 890                 895     


Ala Arg Asp Tyr Leu Ile Leu Lys Gly Val Leu Thr Ala Met Gly Leu 
            900                 905                 910         


Ile Gly Ile Ile Cys Leu Ile Ile Val Val Thr His His Thr Leu Ser 
        915                 920                 925             


Arg Lys Lys Arg Ala Asp Lys Lys Glu Asn Gly Thr Lys Leu Leu 
    930                 935                 940             


<210>  1078
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CLCA2__Homo_sapiens__AAD40367

<400>  1078
augacccaaa ggagcauugc agguccuauu ugcaaccuga aguuugugac ucuccugguu       60

gccuuaaguu cagaacuccc auuccuggga gcuggaguac agcuucaaga caauggguau      120

aauggauugc ucauugcaau uaauccucag guaccugaga aucagaaccu caucucaaac      180

auuaaggaaa ugauaacuga agcuucauuu uaccuauuua augcuaccaa gagaagagua      240

uuuuucagaa auauaaagau uuuaauaccu gccacaugga aagcuaauaa uaacagcaaa      300

auaaaacaag aaucauauga aaaggcaaau gucauaguga cugacuggua uggggcacau      360

ggagaugauc cauacacccu acaauacaga ggguguggaa aagagggaaa auacauucau      420

uucacaccua auuuccuacu gaaugauaac uuaacagcug gcuacggauc acgaggccga      480

guguuugucc augaaugggc ccaccuccgu uggggugugu ucgaugagua uaacaaugac      540

aaaccuuucu acauaaaugg gcaaaaucaa auuaaaguga caagguguuc aucugacauc      600

acaggcauuu uuguguguga aaaagguccu ugcccccaag aaaacuguau uauuaguaag      660

cuuuuuaaag aaggaugcac cuuuaucuac aauagcaccc aaaaugcaac ugcaucaaua      720

auguucaugc aaaguuuauc uucugugguu gaauuuugua augcaaguac ccacaaccaa      780

gaagcaccaa accuacagaa ccagaugugc agccucagaa gugcauggga uguaaucaca      840

gacucugcug acuuucacca cagcuuuccc augaauggga cugagcuucc accuccuccc      900

acauucucgc uuguacaggc uggugacaaa guggucuguu uagugcugga uguguccagc      960

aagauggcag aggcugacag acuccuucaa cuacaacaag ccgcagaauu uuauuugaug     1020

cagauuguug aaauucauac cuucgugggc auugccaguu ucgacagcaa aggagagauc     1080

agagcccagc uacaccaaau uaacagcaau gaugaucgaa aguugcuggu uucauaucug     1140

cccaccacug uaucagcuaa aacagacauc agcauuuguu cagggcuuaa gaaaggauuu     1200

gaggugguug aaaaacugaa uggaaaagcu uauggcucug ugaugauauu agugaccagc     1260

ggagaugaua agcuucuugg caauugcuua cccacugugc ucagcagugg uucaacaauu     1320

cacuccauug cccuggguuc aucugcagcc ccaaaucugg aggaauuauc acgucuuaca     1380

ggagguuuaa aguucuuugu uccagauaua ucaaacucca auagcaugau ugaugcuuuc     1440

aguagaauuu ccucuggaac uggagacauu uuccagcaac auauucagcu ugaaaguaca     1500

ggugaaaaug ucaaaccuca ccaucaauug aaaaacacag ugacugugga uaauacugug     1560

ggcaacgaca cuauguuucu aguuacgugg caggccagug guccuccuga gauuauauua     1620

uuugauccug auggacgaaa auacuacaca aauaauuuua ucaccaaucu aacuuuucgg     1680

acagcuaguc uuuggauucc aggaacagcu aagccugggc acuggacuua cacccugaac     1740

aauacccauc auucucugca agcccugaaa gugacaguga ccucucgcgc cuccaacuca     1800

gcugugcccc cagccacugu ggaagccuuu guggaaagag acagccucca uuuuccucau     1860

ccugugauga uuuaugccaa ugugaaacag ggauuuuauc ccauucuuaa ugccacuguc     1920

acugccacag uugagccaga gacuggagau ccuguuacgc ugagacuccu ugaugaugga     1980

gcaggugcug auguuauaaa aaaugaugga auuuacucga gguauuuuuu cuccuuugcu     2040

gcaaauggua gauauagcuu gaaagugcau gucaaucacu cucccagcau aagcacccca     2100

gcccacucua uuccagggag ucaugcuaug uauguaccag guuacacagc aaacgguaau     2160

auucagauga augcuccaag gaaaucagua ggcagaaaug aggaggagcg aaaguggggc     2220

uuuagccgag ucagcucagg aggcuccuuu ucagugcugg gaguuccagc uggcccccac     2280

ccugaugugu uuccaccaug caaaauuauu gaccuggaag cuguaaaagu agaagaggaa     2340

uugacccuau cuuggacagc accuggagaa gacuuugauc agggccaggc uacaagcuau     2400

gaaauaagaa ugaguaaaag ucuacagaau auccaagaug acuuuaacaa ugcuauuuua     2460

guaaauacau caaagcgaaa uccucagcaa gcuggcauca gggagauauu uacguucuca     2520

ccccagauuu ccacgaaugg accugaacau cagccaaaug gagaaacaca ugaaagccac     2580

agaauuuaug uugcaauacg agcaauggau aggaacuccu uacagucugc uguaucuaac     2640

auugcccagg cgccucuguu uauucccccc aauucugauc cuguaccugc cagagauuau     2700

cuuauauuga aaggaguuuu aacagcaaug gguuugauag gaaucauuug ccuuauuaua     2760

guugugacac aucauacuuu aagcaggaaa aagagagcag acaagaaaga gaauggaaca     2820

aaauuauuau aa                                                         2832


<210>  1079
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CLCA2__Homo_sapiens__AAD40367

<400>  1079
augacccagc gcagcaucgc cggccccauc ugcaaccuga aguucgugac ccuccugguc       60

gcccugucca gcgagcuccc guuccugggg gcgggcgugc agcugcagga caacggguac      120

aacggccucc ugaucgccau caacccccag gugcccgaga accagaaccu gaucuccaac      180

aucaaggaga ugaucacgga ggccagcuuc uaccucuuca acgccaccaa gcggcgcguc      240

uucuuccgga acaucaagau ccugaucccc gccaccugga aggcgaacaa caacuccaag      300

aucaagcagg agagcuacga gaaggccaac gugaucguga ccgacuggua cggggcccac      360

ggcgacgacc cguacacgcu gcaguaccgc ggcugcggga aggagggcaa guacauccac      420

uucaccccca acuuccuccu gaacgacaac cugaccgccg gguacggcuc ccgggggcgc      480

gucuucgugc acgagugggc gcaccuccgg uggggcgugu ucgacgagua caacaacgac      540

aagcccuucu acaucaacgg ccagaaccag aucaagguca cccgcugcag cuccgacauc      600

acggggaucu ucgugugcga gaagggcccc ugcccgcagg agaacugcau caucagcaag      660

cuguucaagg aggggugcac cuucaucuac aacuccaccc agaacgccac cgccagcauc      720

auguucaugc agucccugag cuccgugguc gaguucugca acgccagcac gcacaaccag      780

gaggccccca accuccagaa ccagaugugc ucccugcgga gcgcguggga cgugaucacc      840

gacuccgccg acuuccacca cagcuucccc augaacggca ccgagcugcc cccgccgccc      900

accuucagcc ucgugcaggc cggcgacaag gucgugugcc uggugcugga cgucuccagc      960

aagauggccg aggccgaccg ccuccugcag cugcagcagg cggccgaguu cuaccucaug     1020

cagaucgugg agauccacac guucgugggg aucgccuccu ucgacagcaa gggcgagauc     1080

cgggcccagc ugcaccagau caacuccaac gacgaccgca agcugcucgu cagcuaccug     1140

cccaccaccg uguccgccaa gaccgacauc agcaucugcu ccgggcugaa gaagggcuuc     1200

gagguggucg agaagcucaa cgggaaggcg uacggcagcg ugaugauccu ggucacgucc     1260

ggcgacgaca agcugcucgg gaacugccug cccaccgugc ugagcuccgg cagcaccauc     1320

cacuccaucg cccucgggag cuccgccgcc cccaaccugg aggagcugag ccggcucacc     1380

ggcgggcuga aguucuucgu gcccgacauc uccaacagca acagcaugau cgacgccuuc     1440

ucccgcauca gcuccggcac gggcgacauc uuccagcagc acauccagcu ggagagcacc     1500

ggggagaacg ucaagcccca ccaccagcuc aagaacaccg ugaccgugga caacacgguc     1560

ggcaacgaca ccauguuccu ggugaccugg caggcguccg ggccgcccga gaucauccug     1620

uucgaccccg acggccggaa guacuacacc aacaacuuca ucacgaaccu caccuuccgc     1680

accgccagcc uguggauccc cgggaccgcc aagccgggcc acuggacgua cacccugaac     1740

aacacccacc acucccugca ggcccucaag gugaccguca ccagccgggc guccaacagc     1800

gccgugccgc ccgccacggu ggaggccuuc gucgagcgcg acucccugca cuucccccac     1860

cccgugauga ucuacgccaa cgugaagcag ggcuucuacc ccauccugaa cgcgaccguc     1920

accgccaccg uggagcccga gacgggggac ccggugaccc uccggcugcu ggacgacggc     1980

gccggggccg acgucaucaa gaacgacggc aucuacagcc gcuacuucuu cuccuucgcc     2040

gcgaacggcc gguacagccu caaggugcac gugaaccacu cccccagcau cuccaccccc     2100

gcccacagca uccccgggag ccacgccaug uacgucccgg gcuacaccgc caacgggaac     2160

auccagauga acgcgccccg caaguccgug ggccgcaacg aggaggagcg gaaguggggg     2220

uucagccgcg uguccagcgg cggcuccuuc agcguccugg gggugcccgc cggcccccac     2280

ccggacgugu ucccgcccug caagaucauc gaccuggagg ccgucaaggu ggaggaggag     2340

cucacgcugu ccuggaccgc ccccggggag gacuucgacc agggccaggc caccagcuac     2400

gagauccgga uguccaagag ccugcagaac auccaggacg acuucaacaa cgcgauccuc     2460

gugaacaccu ccaagcgcaa cccccagcag gccgggaucc gggagaucuu cacguucagc     2520

ccccagaucu ccaccaacgg ccccgagcac cagcccaacg gcgagaccca cgagagccac     2580

cgcaucuacg ucgccauccg ggccauggac cgcaacuccc ugcagagcgc cguguccaac     2640

aucgcgcagg ccccgcuguu caucccgccc aacagcgacc ccgugcccgc ccgggacuac     2700

cucauccuga aggggguccu gaccgccaug ggccucaucg ggaucaucug ccugaucauc     2760

guggugacgc accacacccu gucccgcaag aagcgggccg acaagaagga gaacggcacc     2820

aagcuccugu ga                                                         2832


<210>  1080
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CLCA2__Homo_sapiens__AAD40367

<400>  1080
augacccagc gcuccaucgc cggccccauc ugcaaccuca aguucgucac ccuccucguc       60

gcccucuccu ccgagcuccc cuuccucggc gccggcgucc agcuccagga caacggcuac      120

aacggccucc ucaucgccau caacccccag guccccgaga accagaaccu caucuccaac      180

aucaaggaga ugaucaccga ggccuccuuc uaccucuuca acgccaccaa gcgccgcguc      240

uucuuccgca acaucaagau ccucaucccc gccaccugga aggccaacaa caacuccaag      300

aucaagcagg aguccuacga gaaggccaac gucaucguca ccgacuggua cggcgcccac      360

ggcgacgacc ccuacacccu ccaguaccgc ggcugcggca aggagggcaa guacauccac      420

uucaccccca acuuccuccu caacgacaac cucaccgccg gcuacggcuc ccgcggccgc      480

gucuucgucc acgagugggc ccaccuccgc uggggcgucu ucgacgagua caacaacgac      540

aagcccuucu acaucaacgg ccagaaccag aucaagguca cccgcugcuc cuccgacauc      600

accggcaucu ucgucugcga gaagggcccc ugcccccagg agaacugcau caucuccaag      660

cucuucaagg agggcugcac cuucaucuac aacuccaccc agaacgccac cgccuccauc      720

auguucaugc agucccucuc cuccgucguc gaguucugca acgccuccac ccacaaccag      780

gaggccccca accuccagaa ccagaugugc ucccuccgcu ccgccuggga cgucaucacc      840

gacuccgccg acuuccacca cuccuucccc augaacggca ccgagcuccc cccccccccc      900

accuucuccc ucguccaggc cggcgacaag gucgucugcc ucguccucga cgucuccucc      960

aagauggccg aggccgaccg ccuccuccag cuccagcagg ccgccgaguu cuaccucaug     1020

cagaucgucg agauccacac cuucgucggc aucgccuccu ucgacuccaa gggcgagauc     1080

cgcgcccagc uccaccagau caacuccaac gacgaccgca agcuccucgu cuccuaccuc     1140

cccaccaccg ucuccgccaa gaccgacauc uccaucugcu ccggccucaa gaagggcuuc     1200

gaggucgucg agaagcucaa cggcaaggcc uacggcuccg ucaugauccu cgucaccucc     1260

ggcgacgaca agcuccucgg caacugccuc cccaccgucc ucuccuccgg cuccaccauc     1320

cacuccaucg cccucggcuc cuccgccgcc cccaaccucg aggagcucuc ccgccucacc     1380

ggcggccuca aguucuucgu ccccgacauc uccaacucca acuccaugau cgacgccuuc     1440

ucccgcaucu ccuccggcac cggcgacauc uuccagcagc acauccagcu cgaguccacc     1500

ggcgagaacg ucaagcccca ccaccagcuc aagaacaccg ucaccgucga caacaccguc     1560

ggcaacgaca ccauguuccu cgucaccugg caggccuccg gcccccccga gaucauccuc     1620

uucgaccccg acggccgcaa guacuacacc aacaacuuca ucaccaaccu caccuuccgc     1680

accgccuccc ucuggauccc cggcaccgcc aagcccggcc acuggaccua cacccucaac     1740

aacacccacc acucccucca ggcccucaag gucaccguca ccucccgcgc cuccaacucc     1800

gccguccccc ccgccaccgu cgaggccuuc gucgagcgcg acucccucca cuucccccac     1860

cccgucauga ucuacgccaa cgucaagcag ggcuucuacc ccauccucaa cgccaccguc     1920

accgccaccg ucgagcccga gaccggcgac cccgucaccc uccgccuccu cgacgacggc     1980

gccggcgccg acgucaucaa gaacgacggc aucuacuccc gcuacuucuu cuccuucgcc     2040

gccaacggcc gcuacucccu caagguccac gucaaccacu cccccuccau cuccaccccc     2100

gcccacucca uccccggcuc ccacgccaug uacguccccg gcuacaccgc caacggcaac     2160

auccagauga acgccccccg caaguccguc ggccgcaacg aggaggagcg caaguggggc     2220

uucucccgcg ucuccuccgg cggcuccuuc uccguccucg gcguccccgc cggcccccac     2280

cccgacgucu ucccccccug caagaucauc gaccucgagg ccgucaaggu cgaggaggag     2340

cucacccucu ccuggaccgc ccccggcgag gacuucgacc agggccaggc caccuccuac     2400

gagauccgca uguccaaguc ccuccagaac auccaggacg acuucaacaa cgccauccuc     2460

gucaacaccu ccaagcgcaa cccccagcag gccggcaucc gcgagaucuu caccuucucc     2520

ccccagaucu ccaccaacgg ccccgagcac cagcccaacg gcgagaccca cgagucccac     2580

cgcaucuacg ucgccauccg cgccauggac cgcaacuccc uccaguccgc cgucuccaac     2640

aucgcccagg ccccccucuu cauccccccc aacuccgacc ccguccccgc ccgcgacuac     2700

cucauccuca agggcguccu caccgccaug ggccucaucg gcaucaucug ccucaucauc     2760

gucgucaccc accacacccu cucccgcaag aagcgcgccg acaagaagga gaacggcacc     2820

aagcuccucu ga                                                         2832


<210>  1081
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CLCA2__Homo_sapiens__AAD40367

<400>  1081
augacccaga gaagcaucgc cggccccauu ugcaaccuga aguucgugac acuccuuguc       60

gcucuguccu cugaguugcc auuuuuaggg gcaggaguuc aacugcagga caaugguuac      120

aacggccuac ucauagccau caauccucag gugccggaaa accagaaucu gauuucaaac      180

aucaaagaga ugauuacuga agcgaguuuc uaucuuuuua augcuacgaa gaggcgggua      240

uucuuucgca acaucaaaau acugaucccc gccaccugga aggcaaauaa caauagcaaa      300

auuaagcaag aguccuacga aaaggccaac gugaucguca cagauuggua uggggcucac      360

ggagacgauc cuuacacuuu gcaguaucga ggcuguggua aagaggggaa guacauucau      420

uucaccccaa auuuucuccu gaacgacaau cugacagcag gauauggcuc ucguggcaga      480

guguucguuc acgagugggc ccaucucagg uggggagugu uugaugaaua caacaacgac      540

aaacccuucu acaucaaugg gcagaaccag auaaagguca cccggugcuc gucagauauu      600

acugguaucu uuguguguga gaaaggcccu ugcccacaag aaaauuguau uaucagcaag      660

uuauucaagg aggggugcac auuuaucuau aacaguaccc agaaugcuac ggccuccauu      720

auguucaugc agucucugag cuccguaguu gaguucugua acgcgucaac ucacaaucag      780

gaagcaccca accuucaaaa ucagaugugc aguuugcgca gcgccuggga cgugauaacc      840

gauucugcug acuuucauca cuccuucccu augaacggaa cagagcugcc accgcccccu      900

acuuuuaguc uaguccaggc cggcgauaaa gugguguguc ucguccugga cguuagcagu      960

aagauggcag aagcugauag acuucugcaa uugcagcagg ccgcggaguu cuaccucaug     1020

cagaucgugg aaauucacac cuuuguaggu aucgccucuu ucgacuccaa aggggagaua     1080

agggcacaac ugcaucagau uaauagcaac gacgaucgga aguuacuggu gucguaucuc     1140

ccaacaaccg ucucugcuaa aacggacauc uccaucugcu caggacuuaa gaaaggcuuu     1200

gaggugguug aaaagcugaa uggcaaggcc uacgggagug ugaugauuuu ggucacuagc     1260

ggagaugaca aacuacuggg uaacugucuc cccacagugc uguccucugg cagcaccauc     1320

cacucaauug cucuugggag uuccgccgca ccuaaucugg aggaauugag ccgccucacu     1380

ggaggccuga aguucuuugu accagauaua ucuaacucaa acaguaugau cgacgccuuc     1440

agccgaauuu ccucugguac aggggauauc uuucagcagc auauccaauu agagucgacc     1500

ggcgaaaaug uuaaacccca ccaccagcug aagaacacgg ugaccgucga caauacagug     1560

ggaaacgaua cuauguuccu agucaccugg caggcuagcg gcccgccuga gauuauacuc     1620

uuugaccccg augggagaaa auauuacaca aauaacuuca ucacuaaucu gaccuucagg     1680

acagcguccc uuuggauucc aggaaccgca aagccugguc auuggacuua uacguugaac     1740

aauacacacc auucacugca ggcccucaag gugaccguua cuucacgggc uucuaacagc     1800

gccgugcccc cagcaaccgu agaggccuuu gucgaacgug acucccugca cuucccccau     1860

ccugugauga ucuacgcuaa uguuaaacaa ggcuuuuacc caauucuuaa cgccacagug     1920

accgcaacug ucgagccgga aacaggggac cccgugacgc ugcgcuugcu cgaugacgga     1980

gcgggcgcug auguaaucaa gaaugacggu auauauucaa gauacuucuu uagcuucgcc     2040

gcaaacggga gguauucucu gaaagugcac guuaaucacu ccccuaguau cagcacccca     2100

gcccauucua uucccggcuc ccacgcuaug uacgucccug gauauacugc caacggcaac     2160

auccagauga augcaccacg gaagucagug gggcgaaacg aggaggaacg caaaugggga     2220

uuuaguagag ugagcucggg uggcuccuuc ucugucuuag ggguucccgc uggaccgcau     2280

ccugaugugu uuccacccug caagauuauc gaccuggagg ccgugaaggu agaagaggaa     2340

cuaacacuca gcuggaccgc gccuggcgag gauuucgacc agggucaggc cacaucauac     2400

gagauaagga ugaguaaauc ccugcaaaau auucaggaug acuuuaacaa ugcuauccuu     2460

gucaacacuu cuaagcggaa uccccagcaa gcagggauuc gcgaaaucuu caccuuuagc     2520

ccacagauau ccacgaacgg cccugagcac cagcccaaug gagaaaccca cgagucacau     2580

agaaucuaug uggccauuag ggcuauggau cguaacagcu ugcagagugc cguuucuaau     2640

aucgcacaag cgccacuguu cauuccgccu aacuccgacc ccgugccagc ccgggauuac     2700

cucauccuga aaggcgucuu aacagcuaug gggcugauag gaauuaucug ccuuaucauu     2760

gugguuacuc accauaccuu gagccgaaag aaaagagccg acaagaagga aaauggcaca     2820

aaacuccugu ga                                                         2832


<210>  1082
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CLCA2__Homo_sapiens__AAD40367

<400>  1082
augacccaga gaagcaucgc cggccccauc ugcaaccuga aguucgugac ccugcuggug       60

gcccugagca gcgagcugcc cuuccugggc gccggcgugc agcugcagga caacggcuac      120

aacggccugc ugaucgccau caacccccag gugcccgaga accagaaccu gaucagcaac      180

aucaaggaga ugaucaccga ggccagcuuc uaccuguuca acgccaccaa gagaagagug      240

uucuucagaa acaucaagau ccugaucccc gccaccugga aggccaacaa caacagcaag      300

aucaagcagg agagcuacga gaaggccaac gugaucguga ccgacuggua cggcgcccac      360

ggcgacgacc ccuacacccu gcaguacaga ggcugcggca aggagggcaa guacauccac      420

uucaccccca acuuccugcu gaacgacaac cugaccgccg gcuacggcag cagaggcaga      480

guguucgugc acgagugggc ccaccugaga uggggcgugu ucgacgagua caacaacgac      540

aagcccuucu acaucaacgg ccagaaccag aucaagguga ccagaugcag cagcgacauc      600

accggcaucu ucgugugcga gaagggcccc ugcccccagg agaacugcau caucagcaag      660

cuguucaagg agggcugcac cuucaucuac aacagcaccc agaacgccac cgccagcauc      720

auguucaugc agagccugag cagcguggug gaguucugca acgccagcac ccacaaccag      780

gaggccccca accugcagaa ccagaugugc agccugagaa gcgccuggga cgugaucacc      840

gacagcgccg acuuccacca cagcuucccc augaacggca ccgagcugcc cccccccccc      900

accuucagcc uggugcaggc cggcgacaag guggugugcc uggugcugga cgugagcagc      960

aagauggccg aggccgacag acugcugcag cugcagcagg ccgccgaguu cuaccugaug     1020

cagaucgugg agauccacac cuucgugggc aucgccagcu ucgacagcaa gggcgagauc     1080

agagcccagc ugcaccagau caacagcaac gacgacagaa agcugcuggu gagcuaccug     1140

cccaccaccg ugagcgccaa gaccgacauc agcaucugca gcggccugaa gaagggcuuc     1200

gagguggugg agaagcugaa cggcaaggcc uacggcagcg ugaugauccu ggugaccagc     1260

ggcgacgaca agcugcuggg caacugccug cccaccgugc ugagcagcgg cagcaccauc     1320

cacagcaucg cccugggcag cagcgccgcc cccaaccugg aggagcugag cagacugacc     1380

ggcggccuga aguucuucgu gcccgacauc agcaacagca acagcaugau cgacgccuuc     1440

agcagaauca gcagcggcac cggcgacauc uuccagcagc acauccagcu ggagagcacc     1500

ggcgagaacg ugaagcccca ccaccagcug aagaacaccg ugaccgugga caacaccgug     1560

ggcaacgaca ccauguuccu ggugaccugg caggccagcg gcccccccga gaucauccug     1620

uucgaccccg acggcagaaa guacuacacc aacaacuuca ucaccaaccu gaccuucaga     1680

accgccagcc uguggauccc cggcaccgcc aagcccggcc acuggaccua cacccugaac     1740

aacacccacc acagccugca ggcccugaag gugaccguga ccagcagagc cagcaacagc     1800

gccgugcccc ccgccaccgu ggaggccuuc guggagagag acagccugca cuucccccac     1860

cccgugauga ucuacgccaa cgugaagcag ggcuucuacc ccauccugaa cgccaccgug     1920

accgccaccg uggagcccga gaccggcgac cccgugaccc ugagacugcu ggacgacggc     1980

gccggcgccg acgugaucaa gaacgacggc aucuacagca gauacuucuu cagcuucgcc     2040

gccaacggca gauacagccu gaaggugcac gugaaccaca gccccagcau cagcaccccc     2100

gcccacagca uccccggcag ccacgccaug uacgugcccg gcuacaccgc caacggcaac     2160

auccagauga acgcccccag aaagagcgug ggcagaaacg aggaggagag aaaguggggc     2220

uucagcagag ugagcagcgg cggcagcuuc agcgugcugg gcgugcccgc cggcccccac     2280

cccgacgugu ucccccccug caagaucauc gaccuggagg ccgugaaggu ggaggaggag     2340

cugacccuga gcuggaccgc ccccggcgag gacuucgacc agggccaggc caccagcuac     2400

gagaucagaa ugagcaagag ccugcagaac auccaggacg acuucaacaa cgccauccug     2460

gugaacacca gcaagagaaa cccccagcag gccggcauca gagagaucuu caccuucagc     2520

ccccagauca gcaccaacgg ccccgagcac cagcccaacg gcgagaccca cgagagccac     2580

agaaucuacg uggccaucag agccauggac agaaacagcc ugcagagcgc cgugagcaac     2640

aucgcccagg ccccccuguu cauccccccc aacagcgacc ccgugcccgc cagagacuac     2700

cugauccuga agggcgugcu gaccgccaug ggccugaucg gcaucaucug ccugaucauc     2760

guggugaccc accacacccu gagcagaaag aagagagccg acaagaagga gaacggcacc     2820

aagcugcugu ga                                                         2832


<210>  1083
<211>  2832
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CLCA2__Homo_sapiens__AAD40367

<400>  1083
augacccaga gaagcaucgc cggccccauu ugcaaccuga aguucgugac acuccugguc       60

gcucuuuccu cugagcugcc uuuucucggg gccggaguuc aacugcagga caauggcuac      120

aacgggcuuc ugaucgcgau uaauccccag gugcccgaaa accagaaucu caucagcaac      180

auuaaagaga ugaucacgga agcuagcuuc uaucuguuua augccaccaa gcggcgcgug      240

uucuuuagaa acaucaaaau ucugaucccu gccacaugga aggcuaauaa caauucuaaa      300

auuaagcaag agagcuacga aaaggccaac gucaucguga ccgauuggua uggagcucac      360

ggcgacgauc ccuacacacu ccaguaucgg ggguguggaa aagagggcaa guacauucau      420

uucaccccua auuuucugcu uaacgacaau cugacagccg gcuauggguc ccgcggaaga      480

guuuucgugc acgagugggc gcaucuccgg uggggcgucu uugaugaaua caacaacgac      540

aaacccuucu acaucaaugg gcagaaccag auuaagguga cccgcugcuc uagcgauauc      600

acgggaaucu uuguuuguga gaaaggcccu ugcccgcaag aaaauuguau uaucuccaag      660

cuguucaagg aggggugcac cuuuauuuau aacagcacac agaaugccac cgcuucuauc      720

auguucaugc agucccuuag cucugugguc gaguucugua acgccuccac acacaaucag      780

gaagcuccca accugcaaaa ucagaugugc agccucagau cugccuggga cgugauuacc      840

gauuccgcgg acuuucauca cagcuucccu augaacggaa cggagcugcc cccucccccg      900

acauuuuccc uggugcaggc cggcgauaaa gucguuuguc ucgugcugga cgugucuagc      960

aagauggcug aagccgaucg gcuucugcaa cuccagcagg cugccgaguu cuaccugaug     1020

cagaucgucg aaauccacac cuuugugggc auugccuccu ucgacagcaa aggggagauc     1080

cgcgcucaac uucaucagau uaauucuaac gacgauagaa agcugcucgu uuccuaucug     1140

ccuacaaccg ugagcgcgaa aaccgacauc ucuauuugca gcggacugaa gaaaggcuuu     1200

gaggucgugg aaaagcucaa ugggaaggcc uacggauccg uuaugauccu ggugacaucu     1260

ggcgaugaca aacuucuggg gaacugucuc cccacggucc ugagcuccgg aagcaccauc     1320

cacucuauug cucuuggcuc cagcgccgcc ccuaaucugg aggaacucuc ucggcugaca     1380

ggcgggcuga aguucuuugu gcccgauauc uccaacagca acuccaugau ugacgcuuuc     1440

ucucgcauca gcuccggaac cggcgauauu uuucagcagc auauccaacu cgagucuaca     1500

ggggaaaaug ucaaacccca ccaccagcug aagaacaccg ugacgguuga caauacagug     1560

ggaaacgaua ccauguuccu ugucaccugg caggccagcg gcccuccgga gauuauccug     1620

uuugaccccg augggagaaa auauuacaca aauaacuuca ucaccaaucu cacauuccgg     1680

acggcguccc uguggauucc uggcaccgcu aagcccggac auuggacaua uacccugaac     1740

aauacacacc auagccuuca ggcccucaag gugaccguua cgucucgcgc cuccaacagc     1800

gcugugccuc ccgccaccgu cgaggcuuuu guggaaagag acucucugca cuucccgcau     1860

ccugugauga ucuacgccaa uguuaaacaa ggcuuuuacc ccauucugaa cgcgacaguc     1920

accgccacag uggagccuga aaccggggac cccgugacgc uccggcugcu ugaugacgga     1980

gcuggcgccg augucaucaa gaaugacggg auuuauucca gauacuucuu uagcuucgcu     2040

gccaacggac gcuauucucu gaaagugcac guuaaucaca gcccuuccau cagcacaccc     2100

gcgcauucua ucccgggcuc ccacgccaug uacgugccug gguauaccgc uaacggcaac     2160

auucagauga augccccgcg gaaguccguc ggaagaaacg aggaggaacg caaauggggc     2220

uuuucccggg ugucuagcgg gggauccuuc ucuguucucg gcgugcccgc ugggccucau     2280

ccggaugucu uucccccuug caagaucauu gaccuggagg ccgugaaggu ugaagaggaa     2340

cugacacuua gcuggaccgc ccccggagag gauuucgacc agggccaggc uaccuccuac     2400

gagaucagaa ugucuaaaag ccuccaaaau auucaggaug acuuuaacaa ugcgauccug     2460

gugaacacau ccaagcgcaa uccucagcaa gccgggaucc gggaaauuuu cacguuuagc     2520

ccccagaucu cuaccaacgg cccugagcac cagcccaaug gagaaacaca cgagucccau     2580

agaauuuaug ucgcuauccg cgccauggau cggaacagcc ugcagucugc cguguccaau     2640

auugcucaag ccccucucuu caucccgccc aacagcgacc cugugcccgc gagagauuac     2700

cugauccuua aaggcguccu gaccgcuaug gggcucauug gaaucauuug ccugaucauu     2760

guugugacac accauacccu gucucgcaag aaacgggccg acaagaagga aaauggcacg     2820

aaacuucucu ga                                                         2832


<210>  1084
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CML28__Homo_sapiens__Q9NQT4

<400>  1084

Met Glu Glu Glu Thr His Thr Asp Ala Lys Ile Arg Ala Glu Asn Gly 
1               5                   10                  15      


Thr Gly Ser Ser Pro Arg Gly Pro Gly Cys Ser Leu Arg His Phe Ala 
            20                  25                  30          


Cys Glu Gln Asn Leu Leu Ser Arg Pro Asp Gly Ser Ala Ser Phe Leu 
        35                  40                  45              


Gln Gly Asp Thr Ser Val Leu Ala Gly Val Tyr Gly Pro Ala Glu Val 
    50                  55                  60                  


Lys Val Ser Lys Glu Ile Phe Asn Lys Ala Thr Leu Glu Val Ile Leu 
65                  70                  75                  80  


Arg Pro Lys Ile Gly Leu Pro Gly Val Ala Glu Lys Ser Arg Glu Arg 
                85                  90                  95      


Leu Ile Arg Asn Thr Cys Glu Ala Val Val Leu Gly Thr Leu His Pro 
            100                 105                 110         


Arg Thr Ser Ile Thr Val Val Leu Gln Val Val Ser Asp Ala Gly Ser 
        115                 120                 125             


Leu Leu Ala Cys Cys Leu Asn Ala Ala Cys Met Ala Leu Val Asp Ala 
    130                 135                 140                 


Gly Val Pro Met Arg Ala Leu Phe Cys Gly Val Ala Cys Ala Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Thr Leu Val Leu Asp Pro Thr Ser Lys Gln Glu Lys Glu 
                165                 170                 175     


Ala Arg Ala Val Leu Thr Phe Ala Leu Asp Ser Val Glu Arg Lys Leu 
            180                 185                 190         


Leu Met Ser Ser Thr Lys Gly Leu Tyr Ser Asp Thr Glu Leu Gln Gln 
        195                 200                 205             


Cys Leu Ala Ala Ala Gln Ala Ala Ser Gln His Val Phe Arg Phe Tyr 
    210                 215                 220                 


Arg Glu Ser Leu Gln Arg Arg Tyr Ser Lys Ser 
225                 230                 235 


<210>  1085
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CML28__Homo_sapiens__AAF82135

<400>  1085
auggaggagg agacgcauac ugacgccaaa auccgugcug aaaauggaac aggguccagc       60

ccucgggguc cuggcugcag ccuccggcac uuugccugcg aacagaaccu gcugucgcgg      120

ccagauggcu cugcuuccuu ccugcaaggu gacaccucug uccuggcggg uguguacggg      180

ccggccgagg ugaaggucag caaagagauu uucaacaagg ccacacucga agugauccug      240

aggccgaaga uugggcugcc ugguguugca gagaagagcc gggagcggcu gaucaggaac      300

acgugcgagg cgguggugcu gggcacguug cacccccgca ccuccaucac cguggugcug      360

cagguuguca gcgaugccgg cucucuccug gccuguuguc ugaaugccgc cugcauggca      420

uugguggaug caggugugcc caugcgggcu cucuucugug gggucgccug cgcccuggac      480

ucugauggga cccucgugcu ggauccuaca uccaagcaag aaaaggaggc ccgggcaguc      540

cugaccuuug cccuggacag cguggaacgg aagcugcuga uguccagcac caaggggcuc      600

uacucagaca cugagcucca gcagugccug gcugcggccc aggccgcuuc gcaacacguc      660

uuccguuucu accgggaauc gcugcagagg cguuacucca agagcuga                   708


<210>  1086
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CML28__Homo_sapiens__AAF82135

<400>  1086
auggaggagg agacccacac cgacgccaag auccgcgccg agaacggcac ggggagcagc       60

ccccggggcc cggggugcag ccugcgccac uucgcgugcg agcagaaccu ccugucccgg      120

cccgacggca gcgccuccuu ccugcagggg gacaccagcg ugcucgccgg cgucuacggc      180

cccgccgagg ugaagguguc caaggagauc uucaacaagg ccacccugga ggucauccug      240

cgccccaaga ucgggcuccc gggcguggcg gagaaguccc gggagcgccu gauccggaac      300

acgugcgagg ccgugguccu ggggacccuc cacccccgca ccuccaucac cguggugcug      360

caggucguga gcgacgccgg cucccugcuc gccugcugcc ugaacgcggc cugcauggcc      420

cugguggacg ccgggguccc caugcgggcc cucuucugcg gcguggcgug cgcccuggac      480

agcgacggca cccuggugcu cgaccccacg uccaagcagg agaaggaggc ccgcgccguc      540

cugaccuucg cccuggacag cguggagcgg aagcuccuga uguccagcac caaggggcug      600

uacuccgaca ccgagcucca gcagugccug gcggccgccc aggccgccag ccagcacgug      660

uuccgcuucu accgggaguc ccugcagcgc cgguacagca agagcuga                   708


<210>  1087
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CML28__Homo_sapiens__AAF82135

<400>  1087
auggaggagg agacccacac cgacgccaag auccgcgccg agaacggcac cggcuccucc       60

ccccgcggcc ccggcugcuc ccuccgccac uucgccugcg agcagaaccu ccucucccgc      120

cccgacggcu ccgccuccuu ccuccagggc gacaccuccg uccucgccgg cgucuacggc      180

cccgccgagg ucaaggucuc caaggagauc uucaacaagg ccacccucga ggucauccuc      240

cgccccaaga ucggccuccc cggcgucgcc gagaaguccc gcgagcgccu cauccgcaac      300

accugcgagg ccgucguccu cggcacccuc cacccccgca ccuccaucac cgucguccuc      360

caggucgucu ccgacgccgg cucccuccuc gccugcugcc ucaacgccgc cugcauggcc      420

cucgucgacg ccggcguccc caugcgcgcc cucuucugcg gcgucgccug cgcccucgac      480

uccgacggca cccucguccu cgaccccacc uccaagcagg agaaggaggc ccgcgccguc      540

cucaccuucg cccucgacuc cgucgagcgc aagcuccuca uguccuccac caagggccuc      600

uacuccgaca ccgagcucca gcagugccuc gccgccgccc aggccgccuc ccagcacguc      660

uuccgcuucu accgcgaguc ccuccagcgc cgcuacucca aguccuga                   708


<210>  1088
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CML28__Homo_sapiens__AAF82135

<400>  1088
auggaggaag agacccacac agacgccaag aucagagcug aaaacggcac ugggagcucc       60

cccaggggac cugguugcuc ucugcggcau uucgcaugug agcagaaucu ccuuucacgc      120

ccagauggca gugccagcuu ucugcaaggg gacacguccg uguuggcggg agucuacggc      180

ccggcugaag uuaaaguguc uaaggagauu uucaacaaag ccaccuuaga gguaauacug      240

cgacccaaga ucggucuacc ugggguggca gaaaaaucgc gugagagacu cauuaggaau      300

acaugcgaag ccgucgugcu gggaacucuu cacccacgga ccucaaucac aguugugcug      360

caggucguga gcgaugcugg caguuugcuc gcauguugcc ugaacgccgc uuguauggcc      420

cugguagacg cgggcguucc caugcgcgca cucuuuugcg ggguggccug ugcuuuagau      480

uccgacggaa cccugguccu ugauccuacu ucuaagcagg agaaggaggc cagagcagug      540

uugacauucg cucuggacag cguggaaagg aaacuacuca uguccucaac caagggucug      600

uauagugaua cggagcuuca gcaaugccug gccgcggccc aggcagcuag ccagcauguc      660

uuucgguucu accgcgaauc uuugcagcga agauauucca aaucauga                   708


<210>  1089
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CML28__Homo_sapiens__AAF82135

<400>  1089
auggaggagg agacccacac cgacgccaag aucagagccg agaacggcac cggcagcagc       60

cccagaggcc ccggcugcag ccugagacac uucgccugcg agcagaaccu gcugagcaga      120

cccgacggca gcgccagcuu ccugcagggc gacaccagcg ugcuggccgg cguguacggc      180

cccgccgagg ugaaggugag caaggagauc uucaacaagg ccacccugga ggugauccug      240

agacccaaga ucggccugcc cggcguggcc gagaagagca gagagagacu gaucagaaac      300

accugcgagg ccguggugcu gggcacccug caccccagaa ccagcaucac cguggugcug      360

caggugguga gcgacgccgg cagccugcug gccugcugcc ugaacgccgc cugcauggcc      420

cugguggacg ccggcgugcc caugagagcc cuguucugcg gcguggccug cgcccuggac      480

agcgacggca cccuggugcu ggaccccacc agcaagcagg agaaggaggc cagagccgug      540

cugaccuucg cccuggacag cguggagaga aagcugcuga ugagcagcac caagggccug      600

uacagcgaca ccgagcugca gcagugccug gccgccgccc aggccgccag ccagcacgug      660

uucagauucu acagagagag ccugcagaga agauacagca agagcuga                   708


<210>  1090
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CML28__Homo_sapiens__AAF82135

<400>  1090
auggaggaag agacccacac agacgccaag aucagagcug aaaacggcac ggggagcucu       60

ccccggggac cuggcugcuc ccugcgccau uucgccugug agcagaaucu ccugagcaga      120

ccggaugggu ccgcgucuuu ucuucaagga gacaccagcg ugcuggcugg cgucuacggg      180

cccgccgaag uuaaaguguc caaggagauu uucaacaaag ccacacucga ggugauccug      240

cggccuaaga uuggacuucc cggcgucgcu gaaaaaucuc gcgagagacu gauccggaau      300

accugcgaag ccgugguucu cggcacacug cacccucgca ccagcauuac agugguccuc      360

caggugguuu ccgaugcugg gagccugcug gccuguugcc uuaacgcggc cuguauggcu      420

cugguggacg ccggaguccc caugagagcu cucuuuugcg gcguggccug ugcgcuggau      480

ucugacggga cccuugugcu ggauccuacg uccaagcagg agaaggaggc ccgggcuguc      540

cucaccuucg cccuggacag cguugaacgc aaacugcuca ugucuuccac aaagggacug      600

uauagcgaua ccgagcuuca gcaaugccug gcugccgccc aggcugcguc ucagcaugug      660

uuuagauucu accgggaauc ccuccagcgc agauauagca aauccuga                   708


<210>  1091
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CML66__Homo_sapiens__Q96RS6

<400>  1091

Met Glu Val Ala Ala Asn Cys Ser Leu Arg Val Lys Arg Pro Leu Leu 
1               5                   10                  15      


Asp Pro Arg Phe Glu Gly Tyr Lys Leu Ser Leu Glu Pro Leu Pro Cys 
            20                  25                  30          


Tyr Gln Leu Glu Leu Asp Ala Ala Val Ala Glu Val Lys Leu Arg Asp 
        35                  40                  45              


Asp Gln Tyr Thr Leu Glu His Met His Ala Phe Gly Met Tyr Asn Tyr 
    50                  55                  60                  


Leu His Cys Asp Ser Trp Tyr Gln Asp Ser Val Tyr Tyr Ile Asp Thr 
65                  70                  75                  80  


Leu Gly Arg Ile Met Asn Leu Thr Val Met Leu Asp Thr Ala Leu Gly 
                85                  90                  95      


Lys Pro Arg Glu Val Phe Arg Leu Pro Thr Asp Leu Thr Ala Cys Asp 
            100                 105                 110         


Asn Arg Leu Cys Ala Ser Ile His Phe Ser Ser Ser Thr Trp Val Thr 
        115                 120                 125             


Leu Ser Asp Gly Thr Gly Arg Leu Tyr Val Ile Gly Thr Gly Glu Arg 
    130                 135                 140                 


Gly Asn Ser Ala Ser Glu Lys Trp Glu Ile Met Phe Asn Glu Glu Leu 
145                 150                 155                 160 


Gly Asp Pro Phe Ile Ile Ile His Ser Ile Ser Leu Leu Asn Ala Glu 
                165                 170                 175     


Glu His Ser Ile Ala Thr Leu Leu Leu Arg Ile Glu Lys Glu Glu Leu 
            180                 185                 190         


Asp Met Lys Gly Ser Gly Phe Tyr Val Ser Leu Glu Trp Val Thr Ile 
        195                 200                 205             


Ser Lys Lys Asn Gln Asp Asn Lys Lys Tyr Glu Ile Ile Lys Arg Asp 
    210                 215                 220                 


Ile Leu Arg Gly Lys Ser Val Pro His Tyr Ala Ala Ile Glu Pro Asp 
225                 230                 235                 240 


Gly Asn Gly Leu Met Ile Val Ser Tyr Lys Ser Leu Thr Phe Val Gln 
                245                 250                 255     


Ala Gly Gln Asp Leu Glu Glu Asn Met Asp Glu Asp Ile Ser Glu Lys 
            260                 265                 270         


Ile Lys Glu Pro Leu Tyr Tyr Trp Gln Gln Thr Glu Asp Asp Leu Thr 
        275                 280                 285             


Val Thr Ile Arg Leu Pro Glu Asp Ser Thr Lys Glu Asp Ile Gln Ile 
    290                 295                 300                 


Gln Phe Leu Pro Asp His Ile Asn Ile Val Leu Lys Asp His Gln Phe 
305                 310                 315                 320 


Leu Glu Gly Lys Leu Tyr Ser Ser Ile Asp His Glu Ser Ser Thr Trp 
                325                 330                 335     


Ile Ile Lys Glu Ser Asn Ser Leu Glu Ile Ser Leu Ile Lys Lys Asn 
            340                 345                 350         


Glu Gly Leu Thr Trp Pro Glu Leu Val Ile Gly Asp Lys Gln Gly Glu 
        355                 360                 365             


Leu Ile Arg Asp Ser Ala Gln Cys Ala Ala Ile Ala Glu Arg Leu Met 
    370                 375                 380                 


His Leu Thr Ser Glu Glu Leu Asn Pro Asn Pro Asp Lys Glu Lys Pro 
385                 390                 395                 400 


Pro Cys Asn Ala Gln Glu Leu Glu Glu Cys Asp Ile Phe Phe Glu Glu 
                405                 410                 415     


Ser Ser Ser Leu Cys Arg Phe Asp Gly Asn Thr Leu Lys Thr Thr His 
            420                 425                 430         


Val Val Asn Leu Gly Ser Asn Gln Tyr Leu Phe Ser Val Ile Val Asp 
        435                 440                 445             


Pro Lys Glu Met Pro Cys Phe Cys Leu Arg His Asp Val Asp Ala Leu 
    450                 455                 460                 


Leu Trp Gln Pro His Ser Ser Lys Gln Asp Asp Met Trp Glu His Ile 
465                 470                 475                 480 


Ala Thr Phe Asn Ala Leu Gly Tyr Val Gln Ala Ser Lys Arg Asp Lys 
                485                 490                 495     


Lys Phe Phe Ala Cys Ala Pro Asn Tyr Ser Tyr Ala Ala Leu Cys Glu 
            500                 505                 510         


Cys Leu Arg Arg Val Phe Ile Tyr Arg Gln Pro Ala Pro Met Ser Thr 
        515                 520                 525             


Val Leu Tyr Asn Arg Lys Glu Gly Arg Gln Val Gly Gln Val Ala Lys 
    530                 535                 540                 


Gln Gln Val Ala Ser Leu Glu Thr Asn Asp Pro Ile Leu Gly Phe Gln 
545                 550                 555                 560 


Ala Thr Asn Glu Arg Leu Phe Val Leu Thr Thr Lys Asn Leu Phe Leu 
                565                 570                 575     


Ile Lys Val Asn Thr Glu Asn 
            580             


<210>  1092
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CML66__Homo_sapiens__CCDS6312.1

<400>  1092
auggaggugg cggcuaauug cucccuacgg gugaagagac cucuguugga uccccgcuuc       60

gaggguuaca agcucucucu ugagccgcug ccuuguuacc agcuggagcu ugacgcagcu      120

guggcagagg uaaaacuucg agaugaucaa uauacacugg aacacaugca ugcuuuugga      180

auguauaauu accugcacug ugauucaugg uaucaagaca gugucuacua uauugauacc      240

cuuggaagaa uuaugaauuu aacaguaaug cuggacacug ccuuaggaaa accacgagag      300

guguuucgac uuccuacaga uuugacagca ugugacaacc gucuuugugc aucuauccau      360

uucucaucuu cuaccugggu uaccuuguca gauggaacug gaagauugua ugucauugga      420

acaggugaac guggaaauag cgcuucugaa aaaugggaga uuauguuuaa ugaagaacuu      480

ggggauccuu uuauuauaau ucacaguauc ucacugcuaa augcugaaga acauucuaua      540

gcuacccuac uucuucgaau agagaaagag gaauuggaua ugaaaggaag ugguuucuau      600

guuucucugg agugggucac uaucaguaag aaaaaucaag auaauaaaaa auaugaaauu      660

auuaagcgug auauucuccg uggaaaguca gugccacauu augcugcuau ugagccugau      720

ggaaaugguc uaaugauugu auccuacaag ucuuuaacau uuguucaggc uggucaagau      780

cuugaagaaa auauggauga agacauauca gagaaaauca aagaaccucu guauuacugg      840

caacagacug aagaugauuu gacaguaacc auacggcuuc cagaagacag uacuaaggag      900

gacauucaaa uacaguuuuu gccugaucac aucaacauug uacugaagga ucaccaguuu      960

uuagaaggaa aacucuauuc aucuauugau caugaaagca guacauggau aauuaaagag     1020

aguaauagcu uggagauuuc cuugauuaag aagaaugaag gacugaccug gccagagcua     1080

guaauuggag auaaacaagg ggaacuuaua agagauucag cccagugugc ugcaauagcu     1140

gaacguuuga ugcauuugac cucugaagaa cugaauccaa auccagauaa agaaaaacca     1200

ccuugcaaug cucaagaguu agaagaaugu gauauuuucu uugaagagag cuccaguuua     1260

ugcagauuug auggcaauac auuaaaaacu acucaugugg ugaaucuugg aagcaaccag     1320

uaccuuuucu cugucauagu ggauccuaaa gaaaugcccu gcuucuguuu gcgccaugau     1380

guugaugccc uacucuggca accacacucc agcaaacaag augauaugug ggagcacauc     1440

gcaacuuuca augcuuuagg cuauguccaa gcaucaaaga gagacaaaaa auuuuuugcc     1500

ugugcuccaa auuacucgua ugcagcccuu ugugagugcc uucgucgagu auucaucuau     1560

cgucagccug cucccauguc cacuguacuu uacaacagaa aggaaggcag gcaaguagga     1620

cagguugcua agcagcaagu agcaagccua gaaaccaaug auccuauuuu aggauuucag     1680

gcaacaaaug agagauuauu uguucuuacu accaaaaacc ucuuuuuaau aaaaguaaau     1740

acagagaauu aa                                                         1752


<210>  1093
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CML66__Homo_sapiens__CCDS6312.1

<400>  1093
auggaggugg ccgccaacug cagccugcgc gucaagcggc cccuccugga cccgcgcuuc       60

gagggcuaca agcugucccu cgagccccug cccugcuacc agcuggagcu cgacgcggcc      120

guggccgagg ugaagcugcg ggacgaccag uacacccugg agcacaugca cgccuucggg      180

auguacaacu accuccacug cgacagcugg uaccaggacu ccgucuacua caucgacacc      240

cugggccgca ucaugaaccu gacggugaug cucgacaccg cccuggggaa gccccgggag      300

guguuccgcc ugccgaccga ccucaccgcg ugcgacaacc ggcugugcgc cagcauccac      360

uucuccagcu ccacgugggu cacccugagc gacggcaccg ggcgccucua cgugaucggc      420

accggcgagc gggggaacuc cgccagcgag aagugggaga ucauguucaa cgaggagcug      480

ggcgaccccu ucaucaucau ccacuccauc agccugcuca acgccgagga gcacuccauc      540

gcgacgcugc ugcuccgcau cgagaaggag gagcuggaca ugaaggggag cggcuucuac      600

gugucccugg agugggucac caucagcaag aagaaccagg acaacaagaa guacgagauc      660

aucaagcggg acauccuccg cgggaagucc gugccccacu acgccgccau cgagcccgac      720

ggcaacggcc ugaugaucgu gagcuacaag ucccugaccu ucguccaggc cgggcaggac      780

cucgaggaga acauggacga ggacaucagc gagaagauca aggagccgcu guacuacugg      840

cagcagaccg aggacgaccu gacggugacc auccggcucc ccgaggacag caccaaggag      900

gacauccaga uccaguuccu gcccgaccac aucaacaucg ugcugaagga ccaccaguuc      960

cucgagggca agcuguacuc cagcaucgac cacgagucca gcaccuggau caucaaggag     1020

uccaacagcc uggagaucuc ccucaucaag aagaacgagg ggcugacgug gcccgagcug     1080

gucaucggcg acaagcaggg cgagcucauc cgcgacagcg cccagugcgc ggccaucgcc     1140

gagcggcuga ugcaccugac cuccgaggag cucaacccga accccgacaa ggagaagccg     1200

cccugcaacg cccaggagcu ggaggagugc gacaucuucu ucgaggagag cuccagccug     1260

ugccgcuucg acgggaacac ccucaagacc acgcacgugg ugaaccuggg cuccaaccag     1320

uaccuguuca gcgucaucgu ggaccccaag gagaugcccu gcuucugccu gcggcacgac     1380

guggacgccc uccuguggca gccccacucc agcaagcagg acgacaugug ggagcacauc     1440

gcgaccuuca acgcccuggg guacguccag gccuccaagc gcgacaagaa guucuucgcc     1500

ugcgccccca acuacagcua cgcggcccuc ugcgagugcc ugcggcgcgu guucaucuac     1560

cggcagccgg cccccauguc caccgugcug uacaaccgca aggagggccg ccaggucggc     1620

cagguggcca agcagcaggu cgccagccuc gagaccaacg accccauccu gggguuccag     1680

gcgacgaacg agcggcuguu cgugcucacc accaagaacc uguuccugau caaggugaac     1740

accgagaacu ga                                                         1752


<210>  1094
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CML66__Homo_sapiens__CCDS6312.1

<400>  1094
auggaggucg ccgccaacug cucccuccgc gucaagcgcc cccuccucga cccccgcuuc       60

gagggcuaca agcucucccu cgagccccuc cccugcuacc agcucgagcu cgacgccgcc      120

gucgccgagg ucaagcuccg cgacgaccag uacacccucg agcacaugca cgccuucggc      180

auguacaacu accuccacug cgacuccugg uaccaggacu ccgucuacua caucgacacc      240

cucggccgca ucaugaaccu caccgucaug cucgacaccg cccucggcaa gccccgcgag      300

gucuuccgcc uccccaccga ccucaccgcc ugcgacaacc gccucugcgc cuccauccac      360

uucuccuccu ccaccugggu cacccucucc gacggcaccg gccgccucua cgucaucggc      420

accggcgagc gcggcaacuc cgccuccgag aagugggaga ucauguucaa cgaggagcuc      480

ggcgaccccu ucaucaucau ccacuccauc ucccuccuca acgccgagga gcacuccauc      540

gccacccucc uccuccgcau cgagaaggag gagcucgaca ugaagggcuc cggcuucuac      600

gucucccucg agugggucac caucuccaag aagaaccagg acaacaagaa guacgagauc      660

aucaagcgcg acauccuccg cggcaagucc gucccccacu acgccgccau cgagcccgac      720

ggcaacggcc ucaugaucgu cuccuacaag ucccucaccu ucguccaggc cggccaggac      780

cucgaggaga acauggacga ggacaucucc gagaagauca aggagccccu cuacuacugg      840

cagcagaccg aggacgaccu caccgucacc auccgccucc ccgaggacuc caccaaggag      900

gacauccaga uccaguuccu ccccgaccac aucaacaucg uccucaagga ccaccaguuc      960

cucgagggca agcucuacuc cuccaucgac cacgaguccu ccaccuggau caucaaggag     1020

uccaacuccc ucgagaucuc ccucaucaag aagaacgagg gccucaccug gcccgagcuc     1080

gucaucggcg acaagcaggg cgagcucauc cgcgacuccg cccagugcgc cgccaucgcc     1140

gagcgccuca ugcaccucac cuccgaggag cucaacccca accccgacaa ggagaagccc     1200

cccugcaacg cccaggagcu cgaggagugc gacaucuucu ucgaggaguc cuccucccuc     1260

ugccgcuucg acggcaacac ccucaagacc acccacgucg ucaaccucgg cuccaaccag     1320

uaccucuucu ccgucaucgu cgaccccaag gagaugcccu gcuucugccu ccgccacgac     1380

gucgacgccc uccucuggca gccccacucc uccaagcagg acgacaugug ggagcacauc     1440

gccaccuuca acgcccucgg cuacguccag gccuccaagc gcgacaagaa guucuucgcc     1500

ugcgccccca acuacuccua cgccgcccuc ugcgagugcc uccgccgcgu cuucaucuac     1560

cgccagcccg cccccauguc caccguccuc uacaaccgca aggagggccg ccaggucggc     1620

caggucgcca agcagcaggu cgccucccuc gagaccaacg accccauccu cggcuuccag     1680

gccaccaacg agcgccucuu cguccucacc accaagaacc ucuuccucau caaggucaac     1740

accgagaacu ga                                                         1752


<210>  1095
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CML66__Homo_sapiens__CCDS6312.1

<400>  1095
auggaggugg ccgcuaacug cagccugaga gucaagaggc cccuccuuga cccucgguuc       60

gaaggcuaca aacuguccuu ggagccauua ccguguuauc agcuggaacu agaugcagcc      120

guugcggagg ugaagcuccg cgacgaucaa uacacccugg aacacaugca ugcuuuuggg      180

auguauaauu accuucacug cgacucuugg uaucaggauu caguauacua uaucgacaca      240

cugggacgaa uuaugaacuu gacugugaug cucgauacgg cccuggguaa accccgugag      300

gucuucagac ugccuaccga ccucacagca ugugauaaua gguuaugcgc caguauacau      360

uuuagcuccu cuacuugggu gacccugucg gacggcacag ggcggcuuua cguuaucgga      420

accggcgagc gcgguaacuc agcuagcgaa aagugggaga uuauguucaa ugaagaguug      480

ggggauccau uuaucauuau ccacaguaua ucccugcuaa acgcagagga acauucuauc      540

gccacucucc ugcuuagaau ugagaaagaa gaacuggaca ugaagggaag cggcuucuac      600

guguccuugg aaugggucac aaucucaaag aaaaaucagg auaacaagaa auaugagauu      660

aucaagaggg acauacuccg gggcaaaagu gugccccacu acgcugccau ugagccugac      720

gggaauggac ugaugaucgu aagcuauaag ucuuuaaccu uuguucaggc gggucaagau      780

cuggaagaga acauggacga agauauuucc gagaagauca aagaaccacu cuacuauugg      840

cagcagacgg aggacgaucu uacugugacc auccgccugc ccgaggacuc aacaaaggaa      900

gauauucaga uacaauucuu gccugaccac aucaauauug uccuaaaaga ucaucaguuu      960

cuggagggca agcucuacag caguaucgac cacgaaucuu ccacuuggau aauuaaagag     1020

agcaacucgc uggaaaucuc ucuuaucaag aaaaaugagg ggcugaccug gccagaguug     1080

gugauuggag auaagcaggg cgaacucauc cgagacuccg cacagugugc cgcuauugcc     1140

gagagacuga ugcauuuaac aucagaggag cugaacccga aucccgacaa ggagaaaccu     1200

ccaugcaacg cacaagaacu agaggaaugu gauauauucu uugaggaaag uagcucccuc     1260

ugcagguucg acgguaacac ccugaagacg acucacgugg ucaaucuugg gucuaaccag     1320

uauuuguuua gcguuaucgu ggaucccaaa gagaugccuu guuucugccu gcggcacgac     1380

guagaugcuc uccuguggca gccacauuca aguaagcaag acgauaugug ggagcacauu     1440

gccacauuca augcgcuugg auacgugcag gccuccaaac gugacaagaa guuuuucgca     1500

ugugcuccca acuacagcua ugccgcucug ugcgaaugcu ugcgcagagu cuuuaucuac     1560

aggcagccgg ccccuauguc uaccgugcuc uauaaucgga aagagggccg acagguuggc     1620

caaguggcaa agcagcaggu cgccucacug gaaacuaacg aucccaucuu aggguuccag     1680

gcuacaaaug agcgccuguu ugugcuaacc acgaaaaacc ucuuccugau uaagguaaau     1740

accgaaaacu ga                                                         1752


<210>  1096
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CML66__Homo_sapiens__CCDS6312.1

<400>  1096
auggaggugg ccgccaacug cagccugaga gugaagagac cccugcugga ccccagauuc       60

gagggcuaca agcugagccu ggagccccug cccugcuacc agcuggagcu ggacgccgcc      120

guggccgagg ugaagcugag agacgaccag uacacccugg agcacaugca cgccuucggc      180

auguacaacu accugcacug cgacagcugg uaccaggaca gcguguacua caucgacacc      240

cugggcagaa ucaugaaccu gaccgugaug cuggacaccg cccugggcaa gcccagagag      300

guguucagac ugcccaccga ccugaccgcc ugcgacaaca gacugugcgc cagcauccac      360

uucagcagca gcaccugggu gacccugagc gacggcaccg gcagacugua cgugaucggc      420

accggcgaga gaggcaacag cgccagcgag aagugggaga ucauguucaa cgaggagcug      480

ggcgaccccu ucaucaucau ccacagcauc agccugcuga acgccgagga gcacagcauc      540

gccacccugc ugcugagaau cgagaaggag gagcuggaca ugaagggcag cggcuucuac      600

gugagccugg agugggugac caucagcaag aagaaccagg acaacaagaa guacgagauc      660

aucaagagag acauccugag aggcaagagc gugccccacu acgccgccau cgagcccgac      720

ggcaacggcc ugaugaucgu gagcuacaag agccugaccu ucgugcaggc cggccaggac      780

cuggaggaga acauggacga ggacaucagc gagaagauca aggagccccu guacuacugg      840

cagcagaccg aggacgaccu gaccgugacc aucagacugc ccgaggacag caccaaggag      900

gacauccaga uccaguuccu gcccgaccac aucaacaucg ugcugaagga ccaccaguuc      960

cuggagggca agcuguacag cagcaucgac cacgagagca gcaccuggau caucaaggag     1020

agcaacagcc uggagaucag ccugaucaag aagaacgagg gccugaccug gcccgagcug     1080

gugaucggcg acaagcaggg cgagcugauc agagacagcg cccagugcgc cgccaucgcc     1140

gagagacuga ugcaccugac cagcgaggag cugaacccca accccgacaa ggagaagccc     1200

cccugcaacg cccaggagcu ggaggagugc gacaucuucu ucgaggagag cagcagccug     1260

ugcagauucg acggcaacac ccugaagacc acccacgugg ugaaccuggg cagcaaccag     1320

uaccuguuca gcgugaucgu ggaccccaag gagaugcccu gcuucugccu gagacacgac     1380

guggacgccc ugcuguggca gccccacagc agcaagcagg acgacaugug ggagcacauc     1440

gccaccuuca acgcccuggg cuacgugcag gccagcaaga gagacaagaa guucuucgcc     1500

ugcgccccca acuacagcua cgccgcccug ugcgagugcc ugagaagagu guucaucuac     1560

agacagcccg cccccaugag caccgugcug uacaacagaa aggagggcag acaggugggc     1620

cagguggcca agcagcaggu ggccagccug gagaccaacg accccauccu gggcuuccag     1680

gccaccaacg agagacuguu cgugcugacc accaagaacc uguuccugau caaggugaac     1740

accgagaacu ga                                                         1752


<210>  1097
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CML66__Homo_sapiens__CCDS6312.1

<400>  1097
auggaggugg ccgcuaacug cagccugaga gucaagcggc cccuccugga cccucgcuuc       60

gaaggcuaca aacuuucccu ggagccgcuc cccuguuauc agcuggaacu ugaugccgcg      120

guugcugagg ugaagcugag agacgaucag uacacccucg aacacaugca ugccuuuggg      180

auguauaauu accugcacug cgacucuugg uaucaggaua gcguguacua uaucgacaca      240

cugggacgga uuaugaaccu cacggucaug cuggauaccg cccuuggcaa accucgcgag      300

guguucagac ugcccacaga ccucaccgcu ugugauaauc ggcugugcgc cuccauccau      360

uuuucuagcu ccacaugggu uacccuuucu gacgggacag gacgccugua cgugauuggc      420

accggggaga gaggaaacag cgcuuccgaa aagugggaga ucauguucaa ugaagaacuc      480

ggcgauccuu uuauuaucau ccacagcauu ucucugcuga acgccgagga acauuccauc      540

gcgacgcucc ugcuucggau ugagaaagag gagcuggaca ugaagggcag cggguucuac      600

gucucucucg aaugggugac caucuccaag aaaaaucagg auaacaagaa auaugagauu      660

aucaagcgcg acauucugag aggaaaaagc guuccccacu acgccgcuau cgagccugac      720

ggcaaugggc uuaugaucgu gucuuauaag ucccugacau uuguccaggc cggacaagau      780

cucgaagaga acauggacga agauauuagc gagaagauca aagaaccgcu guacuauugg      840

cagcagaccg aggacgaucu gacagugacc auucggcucc ccgaggacuc cacgaaggaa      900

gauauccaga uucaauuccu gccugaccac aucaauaucg ugcuuaaaga ucaucaguuu      960

cuggagggca agcucuacuc uagcauugac cacgaaucca gcacauggau cauuaaagag     1020

ucuaacuccc uggaaaucag ccuuauuaag aaaaaugagg ggcugaccug gcccgagcuc     1080

gucaucggag auaagcaggg cgaacugauc cgcgacucug cucagugugc cgcgauugcc     1140

gagagacuga ugcaucucac aagcgaggaa cugaacccua aucccgacaa ggagaaaccg     1200

ccuugcaacg cucaagaacu ugaggaaugu gauaucuucu uugaggaauc cucuagccug     1260

ugccgguucg acggcaacac ccucaagacc acacacguug ugaaucuggg guccaaccag     1320

uaucuguuua gcgugauugu cgaucccaaa gagaugccuu guuucugccu ucgccacgac     1380

guggaugccc uccuguggca gccccauucu uccaagcaag acgauaugug ggagcacauc     1440

gcuacguuca augcccuggg auacguucag gccagcaaaa gagacaagaa guuuuucgcu     1500

ugugcgccca acuacucuua ugccgcucuc ugcgaaugcc ugcggagagu guuuauuuac     1560

cgccagccug ccccgauguc caccguccuu uauaaucgga aagagggcag acaggugggg     1620

caaguugcca agcaacaggu ggcuagccug gaaacaaacg aucccauccu cggauuccag     1680

gccaccaaug agcgccuguu uguccugaca accaaaaacc uuuuccucau uaaggugaau     1740

acggaaaacu ga                                                         1752


<210>  1098
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  COA-1/m__Homo_sapiens__Q5T124

<400>  1098

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu 
        275                 280                 285             


Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu 
    290                 295                 300                 


Gly Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val 
305                 310                 315                 320 


Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg 
                325                 330                 335     


Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly 
            340                 345                 350         


Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile 
        355                 360                 365             


Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg 
385                 390                 395                 400 


Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro 
                405                 410                 415     


Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val 
            420                 425                 430         


Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu 
        435                 440                 445             


Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys 
    450                 455                 460                 


Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys 
465                 470                 475                 480 


Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
                485                 490                 495     


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys 
            500                 505                 510         


Pro Gly Pro Ser Pro Ser Pro Gln 
        515                 520 


<210>  1099
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1099
augagcucac cuuuggccuc ccuuagcaag acccgaaaag ugccccugcc cucggagccu       60

augaauccug ggaggcgagg aauccgcauc uauggagaug aagaugaggu ggacauguug      120

agugaugggu guggcucaga agaaaagauc ucagucccuu ccugcuaugg cggcauaggu      180

gccccuguga gucggcaagu cccugcaucc caugacucgg agcugauggc cuucaugacg      240

aggaaguugu gggaccugga gcagcaggug aaggcccaga cugaugagau acuguccaag      300

gaucagaaga uagcggcccu agaggaccug gugcagaccc uccggccaca cccagccgag      360

gcaacccugc agcggcagga ggaacuggag acgaugugug ugcagcugca gcggcagguc      420

agggagaugg agcgguuccu cagugacuau ggccugcagu gggugggcga gcccauggac      480

caggaggacu cagagagcaa gacagucuca gagcauggcg agagggacug gaugacagcc      540

aagaaguucu ggaagccagg ggacucauug gcgcccccug agguggacuu ugacaggcug      600

cuggccagcc ugcaggaucu uagugagcug gugguagagg gugacaccca agugacacca      660

gugcccggcg gggcacggcu gcguacccuc gagcccaucc cgcugaagcu cuaccggaau      720

ggcaucauga uguucgacgg gcccuuccag cccuucuacg aucccuccac acagcgcugc      780

cuccgagaca uauuggaugg cuucuuuccc ucagagcucc agcgacugua ccccaauggg      840

guccccuuua aggugaguga cuugcgcaau caggucuacc uggaggaugg acuggacccc      900

uucccaggcg agggccgugu ggugggcagg cagcugaugc acaaggccuu ggacagggug      960

gaggagcacc caggcuccag gaugacugcu gagaaauuuc ugaacaggcu ccccaaguuu     1020

gugauccggc aaggcgaggu gauugacauc cggggcccca ucagggacac cuugcagaac     1080

ugcugcccau ugccugcccg gauccaggag auuguggugg agacgcccac cuuggccgcu     1140

gagcgagaga ggagccagga gucacccaac acgccggcac ccccgcucuc caugcugcgc     1200

aucaagucug agaaugggga acaggccuuc cuacugauga ugcagccuga caacaccauu     1260

ggggacgugc gagcucugcu agcgcaggcc agggucaugg augccucugc cuuugagauc     1320

uucagcacau ucccgcccac ccucuaccag gacgauacac ucacgcugca ggcugcaggc     1380

cuugugccca aagcagcacu gcugcugcgg gcacgccgag ccccgaaguc cagccugaaa     1440

uucaguccug gucccugucc cggucccggu cccggcccca gucccggucc cggucccggc     1500

cccagucccg gucccggucc cggccccagu cccuguccug gacccagucc cagcccccaa     1560

uaa                                                                   1563


<210>  1100
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1100
augagcagcc cccuggccuc ccucuccaag acccgcaagg ugccgcugcc cagcgagccc       60

augaaccccg gccggcgcgg gauccggauc uacggcgacg aggacgaggu cgacaugcug      120

uccgacgggu gcggcagcga ggagaagauc uccgugccga gcugcuacgg gggcaucggc      180

gcccccgugu cccgccaggu ccccgcgagc cacgacuccg agcucauggc cuucaugacc      240

cggaagcugu gggaccugga gcagcagguc aaggcccaga cggacgagau ccucagcaag      300

gaccagaaga ucgccgcccu ggaggaccug gugcagaccc uccgccccca cccggcggag      360

gccacccugc agcggcagga ggagcuggag accaugugcg ugcagcucca gcgccaggug      420

cgggagaugg agcgcuuccu guccgacuac gggcugcagu gggugggcga gcccauggac      480

caggaggaca gcgaguccaa gacggucagc gagcacgggg agcgggacug gaugaccgcc      540

aagaaguucu ggaagcccgg cgacucccuc gcgcccccgg agguggacuu cgaccgccug      600

cuggccagcc uccaggaccu guccgagcug guggucgagg gggacaccca ggugaccccc      660

gugcccggcg gcgcccggcu ccgcacgcug gagcccaucc cgcugaagcu cuaccggaac      720

gggaucauga uguucgacgg ccccuuccag cccuucuacg accccagcac ccagcgcugc      780

cugcgggaca uccuggacgg guucuucccg agcgagcucc agcgccugua ccccaacggc      840

guccccuuca agguguccga ccugcggaac cagguguacc ucgaggacgg ccuggacccc      900

uucccggggg agggccgcgu cguggggcgg cagcugaugc acaaggcccu cgaccgcgug      960

gaggagcacc ccggcagccg caugaccgcc gagaaguucc ugaaccggcu gcccaaguuc     1020

gucauccgcc agggggaggu gaucgacauc cggggcccca uccgcgacac ccuccagaac     1080

ugcugcccgc ugcccgcccg gauccaggag aucguggucg agacgcccac ccuggcggcc     1140

gagcgcgagc ggucccagga gagcccgaac acccccgccc cgccccucuc caugcugcgc     1200

aucaagagcg agaacggcga gcaggccuuc cugcucauga ugcagcccga caacaccauc     1260

ggggacgugc gggcccugcu ggcgcaggcc cgcgucaugg acgccuccgc cuucgagauc     1320

uucagcacgu ucccgcccac ccucuaccag gacgacaccc ugacccugca ggccgcgggc     1380

cucgugccca aggccgcccu gcugcugcgg gcccgccggg cccccaaguc cagccucaag     1440

uucucccccg ggcccugccc cggcccgggg cccggcccca gccccggccc ggggcccggc     1500

cccucccccg ggccgggccc cgggcccagc cccugcccgg gccccucccc cagcccgcag     1560

uga                                                                   1563


<210>  1101
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1101
auguccuccc cccucgccuc ccucuccaag acccgcaagg ucccccuccc cuccgagccc       60

augaaccccg gccgccgcgg cauccgcauc uacggcgacg aggacgaggu cgacaugcuc      120

uccgacggcu gcggcuccga ggagaagauc uccguccccu ccugcuacgg cggcaucggc      180

gcccccgucu cccgccaggu ccccgccucc cacgacuccg agcucauggc cuucaugacc      240

cgcaagcucu gggaccucga gcagcagguc aaggcccaga ccgacgagau ccucuccaag      300

gaccagaaga ucgccgcccu cgaggaccuc guccagaccc uccgccccca ccccgccgag      360

gccacccucc agcgccagga ggagcucgag accaugugcg uccagcucca gcgccagguc      420

cgcgagaugg agcgcuuccu cuccgacuac ggccuccagu gggucggcga gcccauggac      480

caggaggacu ccgaguccaa gaccgucucc gagcacggcg agcgcgacug gaugaccgcc      540

aagaaguucu ggaagcccgg cgacucccuc gccccccccg aggucgacuu cgaccgccuc      600

cucgccuccc uccaggaccu cuccgagcuc gucgucgagg gcgacaccca ggucaccccc      660

guccccggcg gcgcccgccu ccgcacccuc gagcccaucc cccucaagcu cuaccgcaac      720

ggcaucauga uguucgacgg ccccuuccag cccuucuacg accccuccac ccagcgcugc      780

cuccgcgaca uccucgacgg cuucuucccc uccgagcucc agcgccucua ccccaacggc      840

guccccuuca aggucuccga ccuccgcaac caggucuacc ucgaggacgg ccucgacccc      900

uuccccggcg agggccgcgu cgucggccgc cagcucaugc acaaggcccu cgaccgcguc      960

gaggagcacc ccggcucccg caugaccgcc gagaaguucc ucaaccgccu ccccaaguuc     1020

gucauccgcc agggcgaggu caucgacauc cgcggcccca uccgcgacac ccuccagaac     1080

ugcugccccc uccccgcccg cauccaggag aucgucgucg agacccccac ccucgccgcc     1140

gagcgcgagc gcucccagga gucccccaac acccccgccc ccccccucuc caugcuccgc     1200

aucaaguccg agaacggcga gcaggccuuc cuccucauga ugcagcccga caacaccauc     1260

ggcgacgucc gcgcccuccu cgcccaggcc cgcgucaugg acgccuccgc cuucgagauc     1320

uucuccaccu ucccccccac ccucuaccag gacgacaccc ucacccucca ggccgccggc     1380

cucgucccca aggccgcccu ccuccuccgc gcccgccgcg cccccaaguc cucccucaag     1440

uucucccccg gccccugccc cggccccggc cccggccccu cccccggccc cggccccggc     1500

cccucccccg gccccggccc cggccccucc cccugccccg gccccucccc cuccccccag     1560

uga                                                                   1563


<210>  1102
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1102
augagcuccc cucuggccuc ucucucaaag accagaaaag ugccucuucc aagugagccg       60

augaaccccg gcaggcgggg gauccgcauu uacggagacg aagaugaggu cgacaugcug      120

agcgaugguu gcggcuccga agagaagaua ucuguuccuu cguguuaugg gggaaucggc      180

gcuccagugu cacgacaggu acccgcaagc cacgacagug aauugauggc cuucaugaca      240

cguaaauuau gggaucugga gcaacaggug aaggcgcaga cugacgagau ucuauccaaa      300

gaucagaaga ucgcugcccu cgaagaccug guccaaacgc uuagaccuca uccagcagag      360

gccacccugc agaggcagga agaguuggag acaaugugcg ugcagcucca acggcagguu      420

cgcgaaaugg agagauuucu gucugauuac ggucugcagu ggguggggga acccauggac      480

caggaggaua gcgaauccaa gacugucuca gagcacggag agagggacug gaugaccgcu      540

aaaaaguucu ggaaaccugg cgauagucuc gcaccaccgg aaguggacuu ugaccgguua      600

cuggccagcc uucaagauuu gucugagcug guaguugaag gcgacacaca ggugaccccc      660

gucccugggg gagcucgccu acgaacucuc gagccaauuc cccugaaacu uuauagaaau      720

gguaucauga uguucgaugg cccuuuucag ccauucuacg accccuccac acaaaggugu      780

cugcgggaua uauuggacgg guuuuucccg ucagaacucc agcgucugua uccuaacgga      840

gugcccuuua aggugagcga uuuacgcaau caggucuacc uggaggacgg ccucgaucca      900

uucccuggug aggggagagu ugugggaagg cagcuuaugc auaaggcccu ggaccgggua      960

gaggaacacc ccggcagucg aaugaccgcg gaaaaguuuu ugaaccgccu accaaaauuc     1020

gugaucagac aaggcgaggu cauugauauc agggggccca uucgggacac gcugcagaau     1080

ugcuguccuc ucccagcacg cauccaggaa auagugguug agacuccgac ccuggccgcu     1140

gagagagaaa ggucucagga gucccccaac acacccgccc caccccuuag caugcugcgu     1200

auuaagucgg aaaauggaga gcaagcauuu uugcucauga ugcagccuga caacacuauc     1260

ggugaugugc gggcucuguu agcccaggcg cgagucaugg acgccucugc auucgagauu     1320

uucuccaccu uuccacccac acuguaucag gaugacaccc uaacgcucca agcugccggc     1380

cuggugccga aagcugcccu uuugcugaga gcaaggcgcg ccccuaaguc aagucucaaa     1440

uucagcccag ggcccugccc uggacccggc ccagguccuu cccccgggcc aggcccggga     1500

ccuucucccg gcccagggcc cggaccuagc ccaugucccg guccuucacc gaguccacag     1560

uga                                                                   1563


<210>  1103
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1103
augagcagcc cccuggccag ccugagcaag accagaaagg ugccccugcc cagcgagccc       60

augaaccccg gcagaagagg caucagaauc uacggcgacg aggacgaggu ggacaugcug      120

agcgacggcu gcggcagcga ggagaagauc agcgugccca gcugcuacgg cggcaucggc      180

gcccccguga gcagacaggu gcccgccagc cacgacagcg agcugauggc cuucaugacc      240

agaaagcugu gggaccugga gcagcaggug aaggcccaga ccgacgagau ccugagcaag      300

gaccagaaga ucgccgcccu ggaggaccug gugcagaccc ugagacccca ccccgccgag      360

gccacccugc agagacagga ggagcuggag accaugugcg ugcagcugca gagacaggug      420

agagagaugg agagauuccu gagcgacuac ggccugcagu gggugggcga gcccauggac      480

caggaggaca gcgagagcaa gaccgugagc gagcacggcg agagagacug gaugaccgcc      540

aagaaguucu ggaagcccgg cgacagccug gccccccccg agguggacuu cgacagacug      600

cuggccagcc ugcaggaccu gagcgagcug gugguggagg gcgacaccca ggugaccccc      660

gugcccggcg gcgccagacu gagaacccug gagcccaucc cccugaagcu guacagaaac      720

ggcaucauga uguucgacgg ccccuuccag cccuucuacg accccagcac ccagagaugc      780

cugagagaca uccuggacgg cuucuucccc agcgagcugc agagacugua ccccaacggc      840

gugcccuuca aggugagcga ccugagaaac cagguguacc uggaggacgg ccuggacccc      900

uuccccggcg agggcagagu ggugggcaga cagcugaugc acaaggcccu ggacagagug      960

gaggagcacc ccggcagcag aaugaccgcc gagaaguucc ugaacagacu gcccaaguuc     1020

gugaucagac agggcgaggu gaucgacauc agaggcccca ucagagacac ccugcagaac     1080

ugcugccccc ugcccgccag aauccaggag aucguggugg agacccccac ccuggccgcc     1140

gagagagaga gaagccagga gagccccaac acccccgccc ccccccugag caugcugaga     1200

aucaagagcg agaacggcga gcaggccuuc cugcugauga ugcagcccga caacaccauc     1260

ggcgacguga gagcccugcu ggcccaggcc agagugaugg acgccagcgc cuucgagauc     1320

uucagcaccu ucccccccac ccuguaccag gacgacaccc ugacccugca ggccgccggc     1380

cuggugccca aggccgcccu gcugcugaga gccagaagag cccccaagag cagccugaag     1440

uucagccccg gccccugccc cggccccggc cccggcccca gccccggccc cggccccggc     1500

cccagccccg gccccggccc cggccccagc cccugccccg gccccagccc cagcccccag     1560

uga                                                                   1563


<210>  1104
<211>  1563
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       COA-1/m__Homo_sapiens__CCDS41288.1

<400>  1104
augagcucuc cccuggccuc ccucagcaag accagaaaag ugccucugcc guccgagccc       60

augaacccug gccggcgcgg gaucagaauu uacggagacg aagaugaggu cgacaugcuu      120

ucugauggcu gcgggagcga agagaagauc uccguucccu cuuguuaugg aggcauuggg      180

gcuccuguga gccgccaggu gcccgccucc cacgacagcg aacugauggc guucaugaca      240

cggaaacucu gggaucugga gcaacagguc aaggcucaga cggacgagau ccuuucuaaa      300

gaucagaaga uugccgcccu ggaagaccuc gugcaaaccc ugagaccuca uccggcugag      360

gccacacugc agcggcagga ggaacucgag accaugugcg uucagcugca acgccaggug      420

agagaaaugg agcgguuucu uuccgauuac ggacugcagu gggucggcga acccauggac      480

caggaggaua gcgaaucuaa gacagugucc gagcacggcg agcgcgacug gaugaccgcu      540

aaaaaguucu ggaaaccugg ggauagccuc gcucccccug aaguugacuu ugacagacug      600

cuugcgucuc ugcaagaucu cuccgagcug guggucgaag gagacacaca ggugaccccc      660

gugccgggcg gggcccggcu gcgcacgcuc gagccuaucc cccugaaacu uuauagaaau      720

ggaaucauga uguucgaugg cccuuuucag cccuucuacg accccagcac ccaacggugu      780

cugcgcgaua uucucgacgg guuuuucccu uccgaacugc agagacuuua uccgaacgga      840

guccccuuua agguuucuga ucugcggaau cagguguacc ucgaggacgg ccuggauccu      900

uuccccggcg aggggagagu ggucggacgc cagcugaugc auaaggcucu cgaccgggug      960

gaggaacacc cuggcagcag aaugacagcc gaaaaguuuc ugaaccgccu ucccaaauuc     1020

guuauccggc aaggggaggu gauugauauc agaggaccga uucgcgacac ccugcagaau     1080

ugcuguccuc uccccgcucg gauccaggaa auugucgugg agacaccuac ccuggccgcg     1140

gagagagaac gcucccagga gagccccaac acgccugcuc ccccgcuuuc uaugcugcgg     1200

aucaaguccg aaaauggcga gcaagccuuu cuccugauga ugcagccuga caacacaauc     1260

ggggauguua gagcccugcu cgcccaggcc cgcgugaugg acgccagcgc uuucgagauu     1320

uucucuaccu uuccgcccac acuguaucag gaugacaccc uuacccugca agcggccgga     1380

cucgucccua aagcugcccu gcugcuucgg gccagacggg cucccaagag cucccucaaa     1440

uucucucccg gcccuugccc cggcccuggg cccggaccua gccccggccc ggggccugga     1500

cccuccccug gccccgggcc gggcccuagc cccuguccug gacccucucc cuccccucag     1560

uga                                                                   1563


<210>  1105
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  coactosin-like_protein__Homo_sapiens__Q14019

<400>  1105

Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg Ala Ala Tyr Asn Leu 
1               5                   10                  15      


Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val Thr Phe Lys Tyr Asp 
            20                  25                  30          


Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala Glu Tyr Gln His Phe 
        35                  40                  45              


Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe Ala Phe Val Arg Phe 
    50                  55                  60                  


Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys Phe Ala Leu Ile Thr 
65                  70                  75                  80  


Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg Ala Lys Thr Gly Thr 
                85                  90                  95      


Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn Phe Ala Lys Glu Phe 
            100                 105                 110         


Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp Phe Ile Lys Ser Glu 
        115                 120                 125             


Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala Gln Thr Glu 
    130                 135                 140         


<210>  1106
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1106
auggccacca agaucgacaa agaggcuugc cgggcggcgu acaaccuggu gcgcgacgac       60

ggcucggccg ucaucugggu gacuuuuaaa uaugacggcu ccaccaucgu ccccggcgag      120

cagggagcgg aguaccagca cuucauccag cagugcacag augacguccg guuguuugcc      180

uucgugcgcu ucaccaccgg ggaugccaug agcaagaggu ccaaguuugc ccucaucacg      240

uggaucggug agaacgucag cgggcugcag cgcgccaaaa ccgggacgga caagacccug      300

gugaaggagg ucguacagaa uuucgcuaag gaguuuguga ucagugaucg gaaggagcug      360

gaggaagauu ucaucaagag cgagcugaag aaggcggggg gagccaauua cgacgcccag      420

acggaguaa                                                              429


<210>  1107
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1107
auggccacca agaucgacaa ggaggccugc cgcgcggccu acaaccuggu gcgggacgac       60

ggcagcgccg ucaucugggu gaccuucaag uacgacgggu ccacgaucgu gcccggcgag      120

cagggggccg aguaccagca cuucauccag cagugcaccg acgacguccg ccucuucgcc      180

uucgugcggu ucaccaccgg cgacgcgaug agcaagcgcu ccaaguucgc ccugaucacg      240

uggaucgggg agaacgugag cggccugcag cgggccaaga ccggcaccga caagacccuc      300

gucaaggagg uggugcagaa cuucgccaag gaguucguca ucuccgaccg caaggagcug      360

gaggaggacu ucaucaagag cgagcugaag aaggccgggg gcgcgaacua cgacgcccag      420

acggaguga                                                              429


<210>  1108
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1108
auggccacca agaucgacaa ggaggccugc cgcgccgccu acaaccucgu ccgcgacgac       60

ggcuccgccg ucaucugggu caccuucaag uacgacggcu ccaccaucgu ccccggcgag      120

cagggcgccg aguaccagca cuucauccag cagugcaccg acgacguccg ccucuucgcc      180

uucguccgcu ucaccaccgg cgacgccaug uccaagcgcu ccaaguucgc ccucaucacc      240

uggaucggcg agaacgucuc cggccuccag cgcgccaaga ccggcaccga caagacccuc      300

gucaaggagg ucguccagaa cuucgccaag gaguucguca ucuccgaccg caaggagcuc      360

gaggaggacu ucaucaaguc cgagcucaag aaggccggcg gcgccaacua cgacgcccag      420

accgaguga                                                              429


<210>  1109
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1109
auggccacca agaucgacaa agaggcuugc agagcagccu acaaccuggu gagggaugac       60

ggcagcgcgg ucauuugggu uacauucaag uaugaugggu ccacuauagu gcccggagaa      120

cagggugcug aguaccaaca cuuuauccag caguguacgg acgauguacg ccucuucgcc      180

uuugugcggu ucaccacagg cgacgcaaug ucuaaacgau caaaguuugc ccuuauuacu      240

uggaucgggg aaaaugucag uggacugcag cgugcuaaaa ccggcacaga uaagaccuug      300

gugaaggagg uugugcaaaa cuucgcaaaa gaauuuguca uuagcgacag aaaggaguua      360

gaggaagauu ucaucaaauc cgagcugaag aaagccggug gggcuaauua ugacgcccag      420

acugaauga                                                              429


<210>  1110
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1110
auggccacca agaucgacaa ggaggccugc agagccgccu acaaccuggu gagagacgac       60

ggcagcgccg ugaucugggu gaccuucaag uacgacggca gcaccaucgu gcccggcgag      120

cagggcgccg aguaccagca cuucauccag cagugcaccg acgacgugag acuguucgcc      180

uucgugagau ucaccaccgg cgacgccaug agcaagagaa gcaaguucgc ccugaucacc      240

uggaucggcg agaacgugag cggccugcag agagccaaga ccggcaccga caagacccug      300

gugaaggagg uggugcagaa cuucgccaag gaguucguga ucagcgacag aaaggagcug      360

gaggaggacu ucaucaagag cgagcugaag aaggccggcg gcgccaacua cgacgcccag      420

accgaguga                                                              429


<210>  1111
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       coactosin-like_protein__Homo_sapiens__AAA88022

<400>  1111
auggccacca agaucgacaa agaggcuugc agagccgcgu acaaccuggu gcgggaugac       60

ggcagcgcug ucauuugggu uacauucaag uaugaugggu ccacgaucgu gcccggagaa      120

cagggcgccg aguaccaaca cuuuauucag caguguaccg acgaugugcg ccucuucgcc      180

uuugucagau ucacaaccgg ggacgcuaug ucuaaacgga gcaaguuugc ccugaucaca      240

uggauuggag aaaauguguc cggccuucag cgcgcuaaaa ccgggacaga uaagacccug      300

guuaaggagg ugguccaaaa cuucgccaaa gaauuuguga ucucugacag aaaggagcuc      360

gaggaagauu ucaucaaaag cgagcugaag aaagcgggag gcgccaauua ugacgcucag      420

acggaauga                                                              429


<210>  1112
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  collagen_XXIII__Homo_sapiens__L8EAS4

<400>  1112

Met Ala Thr Arg Asp Pro Trp Val Trp Met Ala Ser Pro Asp Phe Gln 
1               5                   10                  15      


Ala Arg Lys Gly Lys Arg Val His Gln Glu Thr Leu Ala Pro Gly Glu 
            20                  25                  30          


Thr Lys Asp Lys Met Glu Leu Leu Gly Leu Arg Gly Pro Leu Asp Leu 
        35                  40                  45              


Leu Gly Pro Gly Ala Leu Leu Ala Thr Leu Gly Lys Met Ala Pro Gly 
    50                  55                  60                  


Glu His Lys Ala Gln Arg Ala Pro Lys Glu Ser Pro Asp Lys Thr Ala 
65                  70                  75                  80  


Arg Trp Ala Gln Arg Asp Pro Gln Gly Pro Arg Val Ser Leu Glu Tyr 
                85                  90                  95      


Leu Glu Arg Arg Ala Thr Met Gly His Gln Ala Ser Leu Asp His Gln 
            100                 105                 110         


Gly Pro Arg Ala Ser Gln Gly Ala Trp Gly Leu Gly Glu Arg Thr Val 
        115                 120                 125             


Trp Thr Val Pro Gln Asp Arg Arg Gly Ser Leu Ala Thr Glu Ala Arg 
    130                 135                 140                 


Met Glu Leu Gln Gly Pro Gly Val Pro Gln Ala Ser Arg Ala Ser Arg 
145                 150                 155                 160 


Glu Thr Gln Trp 
                


<210>  1113
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1113
auggcuaccc gggaccccug gguuuggaug gcaagcccgg acuuccaggc ccgaaagggg       60

aaaagggugc accaggagac uuuggccccc ggggagacca aggacaagau ggagcugcug      120

ggccuccggg gcccccugga ccuccugggg cccggggccc uccuggcgac acugggaaag      180

auggccccag gggagcacaa ggcccagcgg gccccaaagg agagcccgga caagacggcg      240

agaugggccc aaagggaccc ccagggccca agggugagcc uggaguaccu ggaaagaagg      300

gcgacgaugg gacaccaagc cagccuggac caccagggcc caagggcgag ccagggagca      360

uggggccucg gggagagaac gguguggacg gugccccagg accgaagggg gagccuggcc      420

accgaggcac ggauggagcu gcagggcccc ggggugcccc aggccucaag ggcgagcagg      480

gagacacagu gguga                                                       495


<210>  1114
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1114
auggccaccc gcgaccccug gguguggaug gccagcccgg acuuccaggc gcggaagggc       60

aagcgcgucc accaggagac ccuggccccc ggggagacga aggacaagau ggagcuccug      120

ggccugcggg ggccccucga ccugcugggc cccggggccc uccuggccac ccugggcaag      180

auggccccgg gcgagcacaa ggcgcagcgc gcccccaagg agucccccga caagaccgcc      240

cggugggccc agcgcgaccc ccaggggccg cgggugagcc ucgaguaccu ggagcgccgg      300

gcgaccaugg gccaccaggc cucccuggac caccaggggc cccgcgccag ccagggcgcc      360

ugggggcucg gcgagcggac gguguggacc gucccccagg accgccgggg cucccuggcc      420

accgaggcgc gcauggagcu gcaggggccc ggcgugccgc aggccagccg ggccucccgc      480

gagacccagu gguga                                                       495


<210>  1115
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1115
auggccaccc gcgaccccug ggucuggaug gccucccccg acuuccaggc ccgcaagggc       60

aagcgcgucc accaggagac ccucgccccc ggcgagacca aggacaagau ggagcuccuc      120

ggccuccgcg gcccccucga ccuccucggc cccggcgccc uccucgccac ccucggcaag      180

auggcccccg gcgagcacaa ggcccagcgc gcccccaagg agucccccga caagaccgcc      240

cgcugggccc agcgcgaccc ccagggcccc cgcgucuccc ucgaguaccu cgagcgccgc      300

gccaccaugg gccaccaggc cucccucgac caccagggcc cccgcgccuc ccagggcgcc      360

uggggccucg gcgagcgcac cgucuggacc gucccccagg accgccgcgg cucccucgcc      420

accgaggccc gcauggagcu ccagggcccc ggcguccccc aggccucccg cgccucccgc      480

gagacccagu gguga                                                       495


<210>  1116
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1116
auggccacca gagaccccug gguguggaug gcuagcccug auuuccaggc aaggaagggc       60

aaacgggucc accaagagac acuggcccca ggggaaacua aggacaaaau ggagcuccuu      120

ggacugcgcg guccguugga uuuacugggc cccggggcgc uacucgcuac gcugggaaag      180

auggccccug gcgaacauaa agcacagcga gccccaaagg agucccccga caagaccgcu      240

cguugggcac agagagaucc ucagggucca aggguuucuc uugaauaccu ggagcggcgc      300

gccacaaugg ggcaccaggc uucauuggac caucaaggac ccagagccag ucagggcgcg      360

uggggccucg gggagaggac uguguggacc guaccucagg aucggcgcgg aagccuggca      420

acagaagccc gaauggagcu gcaaggucca ggcgugccgc aggcuuccag agccucuagg      480

gaaacccagu gguga                                                       495


<210>  1117
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1117
auggccacca gagaccccug gguguggaug gccagccccg acuuccaggc cagaaagggc       60

aagagagugc accaggagac ccuggccccc ggcgagacca aggacaagau ggagcugcug      120

ggccugagag gcccccugga ccugcugggc cccggcgccc ugcuggccac ccugggcaag      180

auggcccccg gcgagcacaa ggcccagaga gcccccaagg agagccccga caagaccgcc      240

agaugggccc agagagaccc ccagggcccc agagugagcc uggaguaccu ggagagaaga      300

gccaccaugg gccaccaggc cagccuggac caccagggcc ccagagccag ccagggcgcc      360

uggggccugg gcgagagaac cguguggacc gugccccagg acagaagagg cagccuggcc      420

accgaggcca gaauggagcu gcagggcccc ggcgugcccc aggccagcag agccagcaga      480

gagacccagu gguga                                                       495


<210>  1118
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       collagen_XXIII__Homo_sapiens__CCQ43891

<400>  1118
auggccacca gagaccccug gguguggaug gcuagcccug auuuccaggc ccggaagggc       60

aaacgcgucc accaagagac acuggcgccg ggggaaacga aggacaaaau ggagcuccug      120

ggacuuagag gcccccugga ucuccugggg ccuggagccc uucuggcuac ccucggcaag      180

auggcccccg gggaacauaa agcucagcgg gccccuaagg agucccccga caagacagcu      240

cgcugggccc agagagaucc ucagggaccg cggguuucuc uggaauaccu ggagcgcaga      300

gcgaccaugg gccaccaagc cagccucgac caucagggcc cccgggcuuc ccagggggcc      360

uggggacugg gcgagcgcac aguguggacc gugccucagg auagacgggg gucucuugcu      420

acagaagccc gcauggagcu gcaaggaccc ggcgucccuc aggcgagcag agccucccgg      480

gaaacccagu gguga                                                       495


<210>  1119
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  collagen_XXIII__Homo_sapiens__Q86Y22

<400>  1119

Met Gly Pro Gly Glu Arg Ala Gly Gly Gly Gly Asp Ala Gly Lys Gly 
1               5                   10                  15      


Asn Ala Ala Gly Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Gly 
            20                  25                  30          


Ser Arg Ala Val Ser Ala Leu Cys Leu Leu Leu Ser Val Gly Ser Ala 
        35                  40                  45              


Ala Ala Cys Leu Leu Leu Gly Val Gln Ala Ala Ala Leu Gln Gly Arg 
    50                  55                  60                  


Val Ala Ala Leu Glu Glu Glu Arg Glu Leu Leu Arg Arg Ala Gly Pro 
65                  70                  75                  80  


Pro Gly Ala Leu Asp Ala Trp Ala Glu Pro His Leu Glu Arg Leu Leu 
                85                  90                  95      


Arg Glu Lys Leu Asp Gly Leu Ala Lys Ile Arg Thr Ala Arg Glu Ala 
            100                 105                 110         


Pro Ser Glu Cys Val Cys Pro Pro Gly Pro Pro Gly Arg Arg Gly Lys 
        115                 120                 125             


Pro Gly Arg Arg Gly Asp Pro Gly Pro Pro Gly Gln Ser Gly Arg Asp 
    130                 135                 140                 


Gly Tyr Pro Gly Pro Leu Gly Leu Asp Gly Lys Pro Gly Leu Pro Gly 
145                 150                 155                 160 


Pro Lys Gly Glu Lys Gly Ala Pro Gly Asp Phe Gly Pro Arg Gly Asp 
                165                 170                 175     


Gln Gly Gln Asp Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Ala Arg Gly Pro Pro Gly Asp Thr Gly Lys Asp Gly Pro Arg Gly 
        195                 200                 205             


Ala Gln Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Gln Asp Gly Glu 
    210                 215                 220                 


Met Gly Pro Lys Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Val Pro 
225                 230                 235                 240 


Gly Lys Lys Gly Asp Asp Gly Thr Pro Ser Gln Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Lys Gly Glu Pro Gly Ser Met Gly Pro Arg Gly Glu Asn Gly Val 
            260                 265                 270         


Asp Gly Ala Pro Gly Pro Lys Gly Glu Pro Gly His Arg Gly Thr Asp 
        275                 280                 285             


Gly Ala Ala Gly Pro Arg Gly Ala Pro Gly Leu Lys Gly Glu Gln Gly 
    290                 295                 300                 


Asp Thr Val Val Ile Asp Tyr Asp Gly Arg Ile Leu Asp Ala Leu Lys 
305                 310                 315                 320 


Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly 
                325                 330                 335     


Ala Lys Gly Glu Leu Gly Leu Pro Gly Ala Pro Gly Ile Asp Gly Glu 
            340                 345                 350         


Lys Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Glu Pro Gly Pro Ala 
        355                 360                 365             


Gly Leu Lys Gly Glu Ala Gly Glu Met Gly Leu Ser Gly Leu Pro Gly 
    370                 375                 380                 


Ala Asp Gly Leu Lys Gly Glu Lys Gly Glu Ser Ala Ser Asp Ser Leu 
385                 390                 395                 400 


Gln Glu Ser Leu Ala Gln Leu Ile Val Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Pro Gly Pro Pro Gly Pro Met Gly Leu Gln Gly Ile Gln Gly Pro Lys 
            420                 425                 430         


Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly Ala Ser Gly Glu Arg Gly 
        435                 440                 445             


Pro Ser Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Leu Ile Gly Leu 
    450                 455                 460                 


Pro Gly Thr Lys Gly Glu Lys Gly Arg Pro Gly Glu Pro Gly Leu Asp 
465                 470                 475                 480 


Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly Asp Arg Ser Glu Arg Gly 
                485                 490                 495     


Glu Lys Gly Glu Arg Gly Val Pro Gly Arg Lys Gly Val Lys Gly Gln 
            500                 505                 510         


Lys Gly Glu Pro Gly Pro Pro Gly Leu Asp Gln Pro Cys Pro Val Gly 
        515                 520                 525             


Pro Asp Gly Leu Pro Val Pro Gly Cys Trp His Lys 
    530                 535                 540 


<210>  1120
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  collagen_XXIII__Homo_sapiens__AAO18361

<400>  1120
augggcccag gcgagcgcgc cgguggcggc ggcgacgcgg ggaagggcaa ugcggcgggc       60

ggcggcggcg gagggcgcuc ggcgacgacg gccggguccc gggcggugag cgcgcugugc      120

cugcugcucu ccgugggcuc ggcggcugcc ugccugcugc ugggugucca ggcggccgcg      180

cugcagggcc ggguggcggc gcucgaggag gagcgggagc ugcugcggcg cgcggggccg      240

ccaggcgccc uggacgccug ggccgagccg caccuggagc gccugcugcg ggagaaguug      300

gacggacuag cgaagauccg gacugcucgg gaagcuccau ccgaaugugu cugcccccca      360

gggcccccug gacggcgcgg caagccuggg agaagaggcg acccuggucc uccagggcaa      420

ucaggacgag auggcuaccc gggaccccug gguuuggaug gcaagcccgg acuuccaggc      480

ccgaaagggg aaaagggugc accaggagac uuuggccccc ggggagacca aggacaagau      540

ggagcugcug ggccuccggg gcccccugga ccuccugggg cccggggccc uccuggcgac      600

acugggaaag auggccccag gggagcacaa ggcccagcgg gccccaaagg agagcccgga      660

caagacggcg agaugggccc aaagggaccc ccagggccca agggugagcc uggaguaccu      720

ggaaagaagg gcgacgaugg gacaccaagc cagccuggac caccagggcc caagggcgag      780

ccagggagca uggggccucg gggagagaac gguguggacg gugccccagg accgaagggg      840

gagccuggcc accgaggcac ggauggagcu gcagggcccc ggggugcccc aggccucaag      900

ggcgagcagg gagacacagu ggugaucgac uaugauggca ggaucuugga ugcccucaag      960

gggccucccg gaccacaggg gcccccaggg ccaccaggga ucccuggagc caagggcgag     1020

cuuggauugc ccggugcccc aggaaucgau ggagagaagg gccccaaagg acagaaagga     1080

gacccaggag agccugggcc agcaggacuc aaaggggaag caggcgagau gggcuugucc     1140

ggccucccgg gcgcugacgg ccucaagggg gagaaggggg agucggcguc ugacagccua     1200

caggagagcc uggcucagcu cauaguggag ccagggcccc cuggcccccc uggcccccca     1260

ggcccgaugg gccuccaggg aauccagggu cccaagggcu uggauggagc aaagggagag     1320

aagggugcgu cgggugagag aggccccagc ggccugccug ggccaguugg cccaccgggc     1380

cuuauugggc ugccaggaac caaaggagag aagggcagac ccggggagcc aggacuagau     1440

gguuucccug gaccccgagg agagaaaggu gaucggagcg agcguggaga gaagggagaa     1500

cgaggggucc ccggccggaa aggagugaag ggccagaagg gcgagccggg accaccaggc     1560

cuggaccagc cgugucccgu gggccccgac gggcugccug ugccuggcug cuggcauaag     1620

uga                                                                   1623


<210>  1121
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       collagen_XXIII__Homo_sapiens__AAO18361

<400>  1121
augggccccg gggagcgcgc cggcgggggc ggggacgccg gcaagggcaa cgcggccggg       60

ggcgggggcg ggggccggag cgccaccacc gccggcuccc gcgccgugag cgcgcugugc      120

cuccugcugu ccgucgggag cgccgccgcc ugccuccugc ugggcgugca ggcggccgcc      180

cuccaggggc ggguggccgc ccuggaggag gagcgcgagc ugcuccggcg cgcgggcccg      240

cccggcgccc uggacgccug ggccgagccc caccuggagc ggcuccugcg cgagaagcug      300

gacgggcucg ccaagauccg gacggcgcgc gaggcccccu ccgagugcgu cugcccgccc      360

ggcccgcccg ggcggcgcgg caagcccggg cggcgcggcg accccggccc gcccgggcag      420

agcggccggg acggguaccc cggcccccug gggcuggacg gcaagcccgg ccuccccggg      480

ccgaagggcg agaagggggc ccccggcgac uucgggcccc gcggcgacca gggccaggac      540

ggggccgccg ggcccccggg cccgcccggc ccgcccggcg cgcgggggcc gcccggcgac      600

accgggaagg acggcccccg cggggcccag ggccccgccg gccccaaggg ggagcccggc      660

caggacgggg agaugggccc caaggggccg cccggcccca agggcgagcc cggggugccc      720

ggcaagaagg gggacgacgg cacccccucc cagcccgggc cgcccggccc caagggcgag      780

cccgggagca ugggcccgcg cggggagaac ggcguggacg gggcccccgg ccccaagggc      840

gagcccgggc accggggcac cgacggggcc gcgggcccgc ggggcgcccc cgggcugaag      900

ggcgagcagg gggacacggu cgugaucgac uacgacggcc gcauccugga cgcccucaag      960

gggccgcccg gcccccaggg cccgcccggg ccgcccggca uccccggggc caagggcgag     1020

cuggggcugc ccggcgcgcc cggcaucgac ggggagaagg gccccaaggg gcagaagggc     1080

gaccccgggg agcccggccc ggccggccuc aagggggagg ccggcgagau ggggcugucc     1140

ggccugcccg gcgccgacgg gcucaagggc gagaaggggg agagcgccuc cgacagccug     1200

caggaguccc uggcgcagcu caucguggag cccgggcccc cgggcccgcc cggcccgccc     1260

ggccccaugg ggcugcaggg cauccagggg cccaagggcc uggacggggc caagggcgag     1320

aagggcgcca gcggggagcg cggccccucc gggcuccccg gccccgucgg gccgcccggc     1380

cugaucggcc ugcccgggac caagggcgag aaggggcggc ccggcgagcc cgggcucgac     1440

ggcuuccccg gcccgcgcgg ggagaagggc gaccggagcg agcgcgggga gaagggcgag     1500

cggggcgugc ccgggcgcaa gggcgugaag gggcagaagg gcgagcccgg gcccccgggc     1560

cuggaccagc ccugccccgu cggcccggac gggcugcccg ugcccggcug cuggcacaag     1620

uga                                                                   1623


<210>  1122
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       collagen_XXIII__Homo_sapiens__AAO18361

<400>  1122
augggccccg gcgagcgcgc cggcggcggc ggcgacgccg gcaagggcaa cgccgccggc       60

ggcggcggcg gcggccgcuc cgccaccacc gccggcuccc gcgccgucuc cgcccucugc      120

cuccuccucu ccgucggcuc cgccgccgcc ugccuccucc ucggcgucca ggccgccgcc      180

cuccagggcc gcgucgccgc ccucgaggag gagcgcgagc uccuccgccg cgccggcccc      240

cccggcgccc ucgacgccug ggccgagccc caccucgagc gccuccuccg cgagaagcuc      300

gacggccucg ccaagauccg caccgcccgc gaggcccccu ccgagugcgu cugccccccc      360

ggcccccccg gccgccgcgg caagcccggc cgccgcggcg accccggccc ccccggccag      420

uccggccgcg acggcuaccc cggcccccuc ggccucgacg gcaagcccgg ccuccccggc      480

cccaagggcg agaagggcgc ccccggcgac uucggccccc gcggcgacca gggccaggac      540

ggcgccgccg gcccccccgg cccccccggc ccccccggcg cccgcggccc ccccggcgac      600

accggcaagg acggcccccg cggcgcccag ggccccgccg gccccaaggg cgagcccggc      660

caggacggcg agaugggccc caagggcccc cccggcccca agggcgagcc cggcgucccc      720

ggcaagaagg gcgacgacgg cacccccucc cagcccggcc cccccggccc caagggcgag      780

cccggcucca ugggcccccg cggcgagaac ggcgucgacg gcgcccccgg ccccaagggc      840

gagcccggcc accgcggcac cgacggcgcc gccggccccc gcggcgcccc cggccucaag      900

ggcgagcagg gcgacaccgu cgucaucgac uacgacggcc gcauccucga cgcccucaag      960

ggcccccccg gcccccaggg cccccccggc ccccccggca uccccggcgc caagggcgag     1020

cucggccucc ccggcgcccc cggcaucgac ggcgagaagg gccccaaggg ccagaagggc     1080

gaccccggcg agcccggccc cgccggccuc aagggcgagg ccggcgagau gggccucucc     1140

ggccuccccg gcgccgacgg ccucaagggc gagaagggcg aguccgccuc cgacucccuc     1200

caggaguccc ucgcccagcu caucgucgag cccggccccc ccggcccccc cggccccccc     1260

ggccccaugg gccuccaggg cauccagggc cccaagggcc ucgacggcgc caagggcgag     1320

aagggcgccu ccggcgagcg cggccccucc ggccuccccg gccccgucgg cccccccggc     1380

cucaucggcc uccccggcac caagggcgag aagggccgcc ccggcgagcc cggccucgac     1440

ggcuuccccg gcccccgcgg cgagaagggc gaccgcuccg agcgcggcga gaagggcgag     1500

cgcggcgucc ccggccgcaa gggcgucaag ggccagaagg gcgagcccgg cccccccggc     1560

cucgaccagc ccugccccgu cggccccgac ggccuccccg uccccggcug cuggcacaag     1620

uga                                                                   1623


<210>  1123
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       collagen_XXIII__Homo_sapiens__AAO18361

<400>  1123
augggccccg gggagagagc cggagguggc ggggacgcug gaaagggcaa cgcagccggu       60

gggggaggcg gcgggaggag cgcgaccaca gcuggauccc gggccguguc ugcacugugc      120

cuccuucugu cagucgguag ugccgcugca uguuuguuac ugggcguuca ggccgcugcc      180

cuacaagggc gcguggcggc acucgaagag gaacgagagc ugcuucguag agccggaccu      240

ccaggcgcuc uggaugccug ggcagaaccg cacuuggaga ggcuccugcg ggagaaacug      300

gacggucucg cuaagauccg cacugccaga gaagcgccca gcgagugcgu auguccucca      360

gggcccccug gaaggcgggg caaaccaggc cgccgagggg aucccggacc uccaggucag      420

uccggcagag acggguaccc gggacccuua ggccuggaug guaagccugg gcuuccaggc      480

cccaaaggag aaaagggcgc cccuggggac uucggaccaa ggggugauca gggccaggac      540

ggggcagcug gacccccggg cccucccggu ccaccugggg cccggggacc cccaggcgau      600

acgggcaagg acgggccccg uggagcucaa gguccugccg gcccaaaagg ggagccggga      660

caggauggcg agaugggucc caaggggccu ccaggcccca aaggagaacc uggcgugcca      720

gggaagaaag gagacgaugg cacccccucu cagccggguc cuccagggcc caagggagag      780

ccuggcucga uggguccccg cggcgaaaau ggggucgacg gagcaccagg cccuaagggg      840

gagcccggac auagaggcac agacggugcc gcugggccaa ggggagcgcc gggcuugaaa      900

ggugaacagg gcgauacugu gguuauugac uaugaugggc ggauacugga cgcacuaaag      960

ggaccucccg gcccacaagg gcccccugga ccacccggca ucccuggugc caaaggggag     1020

cucggacugc cgggcgcucc agguauugau ggcgagaagg ggcccaaagg acagaagggc     1080

gacccugggg aaccaggacc cgccggccuu aaaggugagg caggggaaau gggacuguca     1140

ggcuugccug gcgccgaugg gcucaaggga gagaagggug aaagcgcuag ugacucccug     1200

caggagucuu uagcccagcu gaucguggag ccggggcccc caggcccucc cggaccaccu     1260

ggccccaugg gucuccaagg gauucaggga ccaaaaggcc uugauggcgc aaagggggaa     1320

aaaggagcga gcggugagcg aggcccgucc gggcugccug gacccgucgg cccacccggu     1380

uugaucgggc uaccuggaac caagggcgaa aaaggccgcc caggggagcc cggacuggac     1440

gguuuuccug gcccgagagg ggaaaaggga gauaggucag agcggggcga gaagggugaa     1500

cgcggggugc caggaagaaa aggcguaaag ggccagaaag gggagcccgg accucccggu     1560

cucgaccaac caugcccugu uggccccgac gggcugccag ugccuggaug uuggcacaag     1620

uga                                                                   1623


<210>  1124
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       collagen_XXIII__Homo_sapiens__AAO18361

<400>  1124
augggccccg gcgagagagc cggcggcggc ggcgacgccg gcaagggcaa cgccgccggc       60

ggcggcggcg gcggcagaag cgccaccacc gccggcagca gagccgugag cgcccugugc      120

cugcugcuga gcgugggcag cgccgccgcc ugccugcugc ugggcgugca ggccgccgcc      180

cugcagggca gaguggccgc ccuggaggag gagagagagc ugcugagaag agccggcccc      240

cccggcgccc uggacgccug ggccgagccc caccuggaga gacugcugag agagaagcug      300

gacggccugg ccaagaucag aaccgccaga gaggccccca gcgagugcgu gugccccccc      360

ggcccccccg gcagaagagg caagcccggc agaagaggcg accccggccc ccccggccag      420

agcggcagag acggcuaccc cggcccccug ggccuggacg gcaagcccgg ccugcccggc      480

cccaagggcg agaagggcgc ccccggcgac uucggcccca gaggcgacca gggccaggac      540

ggcgccgccg gcccccccgg cccccccggc ccccccggcg ccagaggccc ccccggcgac      600

accggcaagg acggccccag aggcgcccag ggccccgccg gccccaaggg cgagcccggc      660

caggacggcg agaugggccc caagggcccc cccggcccca agggcgagcc cggcgugccc      720

ggcaagaagg gcgacgacgg cacccccagc cagcccggcc cccccggccc caagggcgag      780

cccggcagca ugggccccag aggcgagaac ggcguggacg gcgcccccgg ccccaagggc      840

gagcccggcc acagaggcac cgacggcgcc gccggcccca gaggcgcccc cggccugaag      900

ggcgagcagg gcgacaccgu ggugaucgac uacgacggca gaauccugga cgcccugaag      960

ggcccccccg gcccccaggg cccccccggc ccccccggca uccccggcgc caagggcgag     1020

cugggccugc ccggcgcccc cggcaucgac ggcgagaagg gccccaaggg ccagaagggc     1080

gaccccggcg agcccggccc cgccggccug aagggcgagg ccggcgagau gggccugagc     1140

ggccugcccg gcgccgacgg ccugaagggc gagaagggcg agagcgccag cgacagccug     1200

caggagagcc uggcccagcu gaucguggag cccggccccc ccggcccccc cggccccccc     1260

ggccccaugg gccugcaggg cauccagggc cccaagggcc uggacggcgc caagggcgag     1320

aagggcgcca gcggcgagag aggccccagc ggccugcccg gccccguggg cccccccggc     1380

cugaucggcc ugcccggcac caagggcgag aagggcagac ccggcgagcc cggccuggac     1440

ggcuuccccg gccccagagg cgagaagggc gacagaagcg agagaggcga gaagggcgag     1500

agaggcgugc ccggcagaaa gggcgugaag ggccagaagg gcgagcccgg cccccccggc     1560

cuggaccagc ccugccccgu gggccccgac ggccugcccg ugcccggcug cuggcacaag     1620

uga                                                                   1623


<210>  1125
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       collagen_XXIII__Homo_sapiens__AAO18361

<400>  1125
augggccccg gggagagagc cggaggcggg ggagacgcug gcaaggggaa cgccgcggga       60

ggcggcgggg gaggccggag cgcuaccaca gccggguccc gcgccguguc ugcucugugc      120

cuccugcuua gcgucggauc cgccgcugcc ugucugcucc ugggcguuca ggcggccgcc      180

cuucaaggga gaguggcugc ucuggaagag gaacgggagc uccugcgcag agccggaccu      240

ccgggcgcgc uggaugccug ggcugaaccc caccucgagc ggcugcuucg cgagaaacug      300

gacggccucg ccaagaucag aacggcucgg gaagccccuu cugagugcgu gugucccccu      360

gggcccccug gacgcagagg caaaccgggg cggcgcggag aucccggccc ucccgggcag      420

agcggaagag acggcuaccc uggcccccug gggcuugaug gaaagccggg ccugccuggg      480

cccaaaggag aaaagggcgc cccuggggac uucggccccc ggggagauca gggccaggac      540

ggggcugcgg gacccccugg cccgcccggg ccucccggag cccgcggccc ucccggggau      600

accggcaagg acggaccgag aggcgcucaa gggccugccg gacccaaagg cgagccuggg      660

caggauggag agaugggccc caaggggccu cccggcccga aaggagaacc uggcgucccc      720

gggaagaaag gagacgaugg cacacccucc cagccugggc cgcccggacc uaagggcgag      780

cccgggucua ugggcccucg gggagaaaau ggcguggacg gggcccccgg accuaagggc      840

gagcccgggc auagaggaac cgacggcgcu gccggcccgc gcggggcgcc uggacucaaa      900

ggcgaacagg gggauacagu ugugauugac uaugauggac ggauccugga cgcucugaag      960

gggcccccug gcccccaagg accgccuggg cccccuggca uucccggcgc caaaggagag     1020

cucggccugc ccggggcccc uggaaucgau ggcgagaagg ggccgaaagg acagaagggc     1080

gaccccggcg aaccugggcc cgcuggacuu aaaggcgagg ccggggaaau gggacugagc     1140

ggccucccug gggcugaugg acugaagggc gagaagggcg aauccgccag cgacucucuu     1200

caggaguccc uggcgcagcu cauugucgag cccgggccuc cgggaccccc ugggcccccu     1260

ggccccaugg gacugcaagg cauccagggg ccgaaaggac uggauggcgc caagggcgaa     1320

aaaggggcua gcggagagag aggcccuucu gggcuccccg gacccguggg cccucccggg     1380

cugaucggac uuccuggcac caagggcgaa aaagggcgcc cgggagagcc cggccuggac     1440

ggguuuccug gaccccgggg cgaaaagggg gauagauccg agcgcggaga gaagggcgaa     1500

cggggcguuc cugggagaaa aggagugaag ggccagaaag gggagcccgg accgccuggc     1560

cucgaccaac ccugcccugu cgggcccgac ggccugccug ugcccggaug uuggcacaag     1620

uga                                                                   1623


<210>  1126
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  COX-2__Homo_sapiens__Q6ZYK7

<400>  1126

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Ala Leu His Ala Ser Val Phe Gln 
145                 150                 155                 160 


Asp Arg Ser 
            


<210>  1127
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  COX-2__Homo_sapiens__CAG25548

<400>  1127
augcucgccc gcgcccugcu gcugugcgcg guccuggcgc ucagccauac agcaaauccu       60

ugcuguuccc acccauguca aaaccgaggu guauguauga gugugggauu ugaccaguau      120

aagugcgauu guacccggac aggauucuau ggagaaaacu gcucaacacc ggaauuuuug      180

acaagaauaa aauuauuucu gaaacccacu ccaaacacag ugcacuacau acuuacccac      240

uucaagggau uuuggaacgu ugugaauaac auucccuucc uucgaaaugc aauuaugagu      300

uauguguuga cauccagauc acauuugauu gacaguccac caacuuacaa ugcugacuau      360

ggcuacaaaa gcugggaagc cuucucuaac cucuccuauu auacuagagc ccuuccuccu      420

gugccugaug auugcccgac ucccuugggu gucaaagcac uucacgcauc aguuuuucaa      480

gacagaucau aa                                                          492


<210>  1128
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       COX-2__Homo_sapiens__CAG25548

<400>  1128
augcuggccc gcgcccuccu gcugugcgcg gugcucgccc ugagccacac cgccaacccc       60

ugcugcuccc accccugcca gaaccggggc gucugcauga gcgugggguu cgaccaguac      120

aagugcgacu gcacccgcac cggcuucuac ggggagaacu gcuccacccc cgaguuccug      180

acccggauca agcuguuccu caagcccacc cccaacacgg ugcacuacau ccugacccac      240

uucaagggcu ucuggaacgu cgugaacaac aucccguucc uccgcaacgc caucaugagc      300

uacgugcuga ccucccggag ccaccugauc gacuccccgc ccaccuacaa cgccgacuac      360

ggguacaaga gcugggaggc guucuccaac cucagcuacu acacgcgcgc ccugccgccc      420

guccccgacg acugccccac gccccugggc gugaaggccc uccacgccuc cguguuccag      480

gaccggagcu ga                                                          492


<210>  1129
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       COX-2__Homo_sapiens__CAG25548

<400>  1129
augcucgccc gcgcccuccu ccucugcgcc guccucgccc ucucccacac cgccaacccc       60

ugcugcuccc accccugcca gaaccgcggc gucugcaugu ccgucggcuu cgaccaguac      120

aagugcgacu gcacccgcac cggcuucuac ggcgagaacu gcuccacccc cgaguuccuc      180

acccgcauca agcucuuccu caagcccacc cccaacaccg uccacuacau ccucacccac      240

uucaagggcu ucuggaacgu cgucaacaac auccccuucc uccgcaacgc caucaugucc      300

uacguccuca ccucccgcuc ccaccucauc gacucccccc ccaccuacaa cgccgacuac      360

ggcuacaagu ccugggaggc cuucuccaac cucuccuacu acacccgcgc ccuccccccc      420

guccccgacg acugccccac cccccucggc gucaaggccc uccacgccuc cgucuuccag      480

gaccgcuccu ga                                                          492


<210>  1130
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       COX-2__Homo_sapiens__CAG25548

<400>  1130
augcuggcca gagcucuccu ucugugcgca guguuggccu uaagccacac cgcgaacccc       60

uguugcuccc auccuuguca gaauaggggc gucugcaugu cuguuggguu cgaccaauac      120

aagugugauu gcacacggac uggauuuuau ggugagaacu guucaacgcc agaguuccug      180

acccgcauca aacuauuucu caagccgaca cccaauacug ugcacuacau ucugacccau      240

uucaaaggcu uuuggaacgu agugaauaac auaccuuucc uucgaaaugc uaucaugagu      300

uauguccuga caagccguuc ccacuugauu gacucuccac ccaccuacaa cgccgauuau      360

ggguacaagu cgugggaagc auuuucaaau cucagcuauu acacuagagc ccugccucca      420

gugcccgacg auugcccuac accacuggga guuaaagcuc uccaugcaag uguguuccag      480

gacagguccu ga                                                          492


<210>  1131
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       COX-2__Homo_sapiens__CAG25548

<400>  1131
augcuggcca gagcccugcu gcugugcgcc gugcuggccc ugagccacac cgccaacccc       60

ugcugcagcc accccugcca gaacagaggc gugugcauga gcgugggcuu cgaccaguac      120

aagugcgacu gcaccagaac cggcuucuac ggcgagaacu gcagcacccc cgaguuccug      180

accagaauca agcuguuccu gaagcccacc cccaacaccg ugcacuacau ccugacccac      240

uucaagggcu ucuggaacgu ggugaacaac auccccuucc ugagaaacgc caucaugagc      300

uacgugcuga ccagcagaag ccaccugauc gacagccccc ccaccuacaa cgccgacuac      360

ggcuacaaga gcugggaggc cuucagcaac cugagcuacu acaccagagc ccugcccccc      420

gugcccgacg acugccccac cccccugggc gugaaggccc ugcacgccag cguguuccag      480

gacagaagcu ga                                                          492


<210>  1132
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       COX-2__Homo_sapiens__CAG25548

<400>  1132
augcuggcca gagcucuccu gcuuugcgcc gugcuggcgc ucagccacac cgcuaacccc       60

uguugcuccc auccuuguca gaaucggggc gucugcaugu cuguuggguu cgaccaauac      120

aagugugauu gcacccgcac gggauuuuau ggcgagaacu guagcacccc ggaauuucug      180

acaagaauca aacuuuuccu gaagcccacc ccuaauacag ugcacuacau ucucacccau      240

uucaaagggu uuuggaacgu ggucaauaac auccccuucc ugcggaaugc cauuaugucc      300

uaugugcuga caucucgcag ccaccucauc gacuccccuc ccaccuacaa cgccgauuau      360

ggauacaagu cuugggaggc uuuuagcaau cuguccuauu acacgagagc ccuuccuccg      420

guucccgacg auugcccuac accccugggc gugaaagcuc uccaugccag cgucuuccag      480

gaccggucuu ga                                                          492


<210>  1133
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CP1B1__Homo_sapiens__Q16678

<400>  1133

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  1134
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CP1B1__Homo_sapiens__AAC50809

<400>  1134
augggcacca gccucagccc gaacgacccu uggccgcuaa acccgcuguc cauccagcag       60

accacgcucc ugcuacuccu gucggugcug gccacugugc augugggcca gcggcugcug      120

aggcaacgga ggcggcagcu ccgguccgcg cccccgggcc cguuugcgug gccacugauc      180

ggaaacgcgg cggcgguggg ccaggcggcu caccucucgu ucgcucgccu ggcgcggcgc      240

uacggcgacg uuuuccagau ccgccugggc agcugcccca uaguggugcu gaauggcgag      300

cgcgccaucc accaggcccu ggugcagcag ggcucggccu ucgccgaccg gccggccuuc      360

gccuccuucc gugugguguc cggcggccgc agcauggcuu ucggccacua cucggagcac      420

uggaaggugc agcggcgcgc agcccacagc augaugcgca acuucuucac gcgccagccg      480

cgcagccgcc aaguccucga gggccacgug cugagcgagg cgcgcgagcu gguggcgcug      540

cuggugcgcg gcagcgcgga cggcgccuuc cucgacccga ggccgcugac cgucguggcc      600

guggccaacg ucaugagugc cguguguuuc ggcugccgcu acagccacga cgaccccgag      660

uuccgugagc ugcucagcca caacgaagag uucgggcgca cggugggcgc gggcagccug      720

guggacguga ugcccuggcu gcaguacuuc cccaacccgg ugcgcaccgu uuuccgcgaa      780

uucgagcagc ucaaccgcaa cuucagcaac uucauccugg acaaguucuu gaggcacugc      840

gaaagccuuc ggcccggggc cgccccccgc gacaugaugg acgccuuuau ccucucugcg      900

gaaaagaagg cggccgggga cucgcacggu gguggcgcgc ggcuggauuu ggagaacgua      960

ccggccacua ucacugacau cuucggcgcc agccaggaca cccuguccac cgcgcugcag     1020

uggcugcucc uccucuucac cagguauccu gaugugcaga cucgagugca ggcagaauug     1080

gaucaggucg uggggaggga ccgucugccu uguaugggug accagcccaa ccugcccuau     1140

guccuggccu uccuuuauga agccaugcgc uucuccagcu uugugccugu cacuauuccu     1200

caugccacca cugccaacac cucugucuug ggcuaccaca uucccaagga cacugugguu     1260

uuugucaacc aguggucugu gaaucaugac ccacugaagu ggccuaaccc ggagaacuuu     1320

gauccagcuc gauucuugga caaggacggc cucaucaaca aggaccugac cagcagagug     1380

augauuuuuu cagugggcaa aaggcggugc auuggcgaag aacuuucuaa gaugcagcuu     1440

uuucucuuca ucuccauccu ggcucaccag ugcgauuuca gggccaaccc aaaugagccu     1500

gcgaaaauga auuucaguua uggucuaacc auuaaaccca agucauuuaa agucaauguc     1560

acucucagag aguccaugga gcuccuugau agugcugucc aaaauuuaca agccaaggaa     1620

acuugccaau aa                                                         1632


<210>  1135
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CP1B1__Homo_sapiens__AAC50809

<400>  1135
augggcacca gccugucccc caacgacccg uggccccuca acccccugag cauccagcag       60

accacgcugc uccugcugcu cuccgugcug gccaccgucc acguggggca gcgccugcuc      120

cggcagcgcc ggcgccagcu gcggagcgcg cccccgggcc ccuucgccug gccccugauc      180

gggaacgccg ccgccguggg ccaggccgcg caccucuccu ucgcccgccu ggcccggcgc      240

uacggggacg ucuuccagau ccggcugggc agcugcccca ucguggugcu caacggcgag      300

cgcgccaucc accaggcgcu gguccagcag ggguccgccu ucgccgaccg gccggccuuc      360

gccagcuucc gcgugguguc cggcgggcgg agcauggcgu ucggccacua cuccgagcac      420

uggaaggucc agcgccgggc cgcccacagc augaugcgca acuucuucac ccggcagccc      480

cgcucccgcc aggugcugga ggggcacgug cucagcgagg cccgggagcu ggucgcccug      540

cucgugcggg gcuccgcgga cggcgccuuc cuggaccccc gcccccugac cguggucgcc      600

guggccaacg ugaugagcgc cgucugcuuc gggugccgcu acucccacga cgacccggag      660

uuccgggagc uccugagcca caacgaggag uucggccgca cggugggggc gggcucccug      720

guggacguca ugcccuggcu ccaguacuuc cccaaccccg ugcggaccgu guuccgcgag      780

uucgagcagc ugaaccggaa cuucagcaac uucauccugg acaaguuccu ccgccacugc      840

gagagccugc ggccgggcgc cgcgccccgc gacaugaugg acgccuucau ccuguccgcc      900

gagaagaagg ccgccgggga cagccacggc gggggcgccc ggcucgaccu ggagaacguc      960

cccgccacca ucaccgacau cuucggggcg ucccaggaca cgcugagcac cgcccuccag     1020

uggcugcugc uccuguucac ccgcuacccc gacgugcaga cccgggucca ggccgagcug     1080

gaccaggugg ugggccgcga ccggcucccg ugcaugggcg accagcccaa ccugcccuac     1140

guccuggccu uccucuacga ggccaugcgc uucuccagcu ucgugcccgu gacgaucccg     1200

cacgcgacca ccgccaacac cuccguccug ggguaccaca uccccaagga cacgguggug     1260

uucgucaacc aguggagcgu gaaccacgac ccccugaagu ggcccaaccc ggagaacuuc     1320

gaccccgccc gguuccucga caaggacggc cugaucaaca aggaccugac cucccgcgug     1380

augaucuuca gcgucgggaa gcggcgcugc aucggcgagg agcuguccaa gaugcagcug     1440

uuccucuuca ucagcauccu ggcccaccag ugcgacuucc gggccaaccc caacgagccg     1500

gcgaagauga acuucuccua cgggcucacc aucaagccca agagcuucaa ggugaacgug     1560

acccugcgcg aguccaugga gcugcucgac agcgccgucc agaaccugca ggccaaggag     1620

acgugccagu ga                                                         1632


<210>  1136
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CP1B1__Homo_sapiens__AAC50809

<400>  1136
augggcaccu cccucucccc caacgacccc uggccccuca acccccucuc cauccagcag       60

accacccucc uccuccuccu cuccguccuc gccaccgucc acgucggcca gcgccuccuc      120

cgccagcgcc gccgccagcu ccgcuccgcc ccccccggcc ccuucgccug gccccucauc      180

ggcaacgccg ccgccgucgg ccaggccgcc caccucuccu ucgcccgccu cgcccgccgc      240

uacggcgacg ucuuccagau ccgccucggc uccugcccca ucgucguccu caacggcgag      300

cgcgccaucc accaggcccu cguccagcag ggcuccgccu ucgccgaccg ccccgccuuc      360

gccuccuucc gcgucgucuc cggcggccgc uccauggccu ucggccacua cuccgagcac      420

uggaaggucc agcgccgcgc cgcccacucc augaugcgca acuucuucac ccgccagccc      480

cgcucccgcc agguccucga gggccacguc cucuccgagg cccgcgagcu cgucgcccuc      540

cucguccgcg gcuccgccga cggcgccuuc cucgaccccc gcccccucac cgucgucgcc      600

gucgccaacg ucauguccgc cgucugcuuc ggcugccgcu acucccacga cgaccccgag      660

uuccgcgagc uccucuccca caacgaggag uucggccgca ccgucggcgc cggcucccuc      720

gucgacguca ugcccuggcu ccaguacuuc cccaaccccg uccgcaccgu cuuccgcgag      780

uucgagcagc ucaaccgcaa cuucuccaac uucauccucg acaaguuccu ccgccacugc      840

gagucccucc gccccggcgc cgccccccgc gacaugaugg acgccuucau ccucuccgcc      900

gagaagaagg ccgccggcga cucccacggc ggcggcgccc gccucgaccu cgagaacguc      960

cccgccacca ucaccgacau cuucggcgcc ucccaggaca cccucuccac cgcccuccag     1020

uggcuccucc uccucuucac ccgcuacccc gacguccaga cccgcgucca ggccgagcuc     1080

gaccaggucg ucggccgcga ccgccucccc ugcaugggcg accagcccaa ccuccccuac     1140

guccucgccu uccucuacga ggccaugcgc uucuccuccu ucguccccgu caccaucccc     1200

cacgccacca ccgccaacac cuccguccuc ggcuaccaca uccccaagga caccgucguc     1260

uucgucaacc agugguccgu caaccacgac ccccucaagu ggcccaaccc cgagaacuuc     1320

gaccccgccc gcuuccucga caaggacggc cucaucaaca aggaccucac cucccgcguc     1380

augaucuucu ccgucggcaa gcgccgcugc aucggcgagg agcucuccaa gaugcagcuc     1440

uuccucuuca ucuccauccu cgcccaccag ugcgacuucc gcgccaaccc caacgagccc     1500

gccaagauga acuucuccua cggccucacc aucaagccca aguccuucaa ggucaacguc     1560

acccuccgcg aguccaugga gcuccucgac uccgccgucc agaaccucca ggccaaggag     1620

accugccagu ga                                                         1632


<210>  1137
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CP1B1__Homo_sapiens__AAC50809

<400>  1137
augggcacca gccugucccc caacgacccu uggccacuca auccgcuuuc uauccagcaa       60

acaacucugu uguuacugcu aucagugcuc gccacggucc acguugggca gagacugcuu      120

aggcagcggc gccgacagcu gcguagugcu cccccuggac cauucgcaug gcccuugauu      180

gguaacgccg cggcuguggg ccaagccgca caucucagcu uugccagacu ggcuaggcgg      240

uacggggaug uauuccagau acgccuggga uccugcccua ucgugguccu caauggcgag      300

agagcaauuc accaggccuu agugcagcaa gguucugcuu uugccgacag gccagcguuc      360

gcaucguuuc ggguuguguc agggggacgc agcauggccu ucggccauua uagugaacac      420

uggaaggucc agagacgagc ugcccauucc augaugagga acuuuuucac ccggcagccc      480

cguucucgcc aggugcugga gggccacgua cuuagcgaag caagagaguu gguugcucug      540

cuagugaggg gguccgccga uggagcguuu cucgacccuc ggccacugac agucguggcc      600

guggcaaaug ucaugucagc uguuuguuuc gguugccgau acagucacga ugacccggaa      660

uuucgcgagc uucugagcca uaacgaggag uucggcagaa cugugggggc cggaucuuug      720

guagauguga ugcccuggcu ccaauauuuu ccuaauccag ucaggaccgu guuccgggag      780

uucgaacagc ugaaccgcaa uuuuuccaac uucaucuuag acaaauuucu gagacacugu      840

gagucacuca ggcccggcgc ugccccucgu gauaugaugg acgcauucau ucuuagcgcc      900

gagaagaaag cugcggguga uagucauggg ggaggcgcac ggcuggacuu ggaaaauguu      960

ccagccacaa ucaccgauau auuuggcgcu ucucaggaca cucuauccac agcccugcaa     1020

uggcuccugc uucuguucac ccgauacccc gacgugcaga cgagagucca ggcagaguug     1080

gaucaggugg uagggaggga ccgccucccg ugcaugggag aucaaccuaa ccugcccuau     1140

guuuuagccu uucuguacga agcuaugcgg uucagcucgu uugugccagu cacuaucccu     1200

cacgccacca cagcaaauac uucugugcua gguuaucaca uucccaagga caccgucgug     1260

uucguuaacc agugguccgu gaaucaugau ccacucaaau ggcccaaccc ugagaacuuu     1320

gacccagcga gauuccugga uaaggacggc cuuaucaaua aggauuugac aucaagggua     1380

augauuuuua gugucgggaa acgccgaugu aucggagaag aacugagcaa gaugcaacuc     1440

uuccuguuca uauccauucu ugcucaccag ugcgacuuuc gggccaaccc gaaugagccc     1500

gcaaaaauga acuucucuua cggccugacc aucaagccua agagcuuuaa agugaauguu     1560

acguugcgug aaucaaugga gcuccuggau agugccgugc agaacuuaca ggcuaaggaa     1620

acuugucagu ga                                                         1632


<210>  1138
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CP1B1__Homo_sapiens__AAC50809

<400>  1138
augggcacca gccugagccc caacgacccc uggccccuga acccccugag cauccagcag       60

accacccugc ugcugcugcu gagcgugcug gccaccgugc acgugggcca gagacugcug      120

agacagagaa gaagacagcu gagaagcgcc ccccccggcc ccuucgccug gccccugauc      180

ggcaacgccg ccgccguggg ccaggccgcc caccugagcu ucgccagacu ggccagaaga      240

uacggcgacg uguuccagau cagacugggc agcugcccca ucguggugcu gaacggcgag      300

agagccaucc accaggcccu ggugcagcag ggcagcgccu ucgccgacag acccgccuuc      360

gccagcuuca gaguggugag cggcggcaga agcauggccu ucggccacua cagcgagcac      420

uggaaggugc agagaagagc cgcccacagc augaugagaa acuucuucac cagacagccc      480

agaagcagac aggugcugga gggccacgug cugagcgagg ccagagagcu gguggcccug      540

cuggugagag gcagcgccga cggcgccuuc cuggacccca gaccccugac cgugguggcc      600

guggccaacg ugaugagcgc cgugugcuuc ggcugcagau acagccacga cgaccccgag      660

uucagagagc ugcugagcca caacgaggag uucggcagaa ccgugggcgc cggcagccug      720

guggacguga ugcccuggcu gcaguacuuc cccaaccccg ugagaaccgu guucagagag      780

uucgagcagc ugaacagaaa cuucagcaac uucauccugg acaaguuccu gagacacugc      840

gagagccuga gacccggcgc cgcccccaga gacaugaugg acgccuucau ccugagcgcc      900

gagaagaagg ccgccggcga cagccacggc ggcggcgcca gacuggaccu ggagaacgug      960

cccgccacca ucaccgacau cuucggcgcc agccaggaca cccugagcac cgcccugcag     1020

uggcugcugc ugcuguucac cagauacccc gacgugcaga ccagagugca ggccgagcug     1080

gaccaggugg ugggcagaga cagacugccc ugcaugggcg accagcccaa ccugcccuac     1140

gugcuggccu uccuguacga ggccaugaga uucagcagcu ucgugcccgu gaccaucccc     1200

cacgccacca ccgccaacac cagcgugcug ggcuaccaca uccccaagga caccguggug     1260

uucgugaacc aguggagcgu gaaccacgac ccccugaagu ggcccaaccc cgagaacuuc     1320

gaccccgcca gauuccugga caaggacggc cugaucaaca aggaccugac cagcagagug     1380

augaucuuca gcgugggcaa gagaagaugc aucggcgagg agcugagcaa gaugcagcug     1440

uuccuguuca ucagcauccu ggcccaccag ugcgacuuca gagccaaccc caacgagccc     1500

gccaagauga acuucagcua cggccugacc aucaagccca agagcuucaa ggugaacgug     1560

acccugagag agagcaugga gcugcuggac agcgccgugc agaaccugca ggccaaggag     1620

accugccagu ga                                                         1632


<210>  1139
<211>  1632
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CP1B1__Homo_sapiens__AAC50809

<400>  1139
augggcacca gccugucccc caacgacccu uggccgcuca auccccuguc uauccagcaa       60

acaacgcuuc ugcuccugcu uagcgugcug gccaccgucc acguugggca gagacuccug      120

cggcagcgca gacggcagcu gcgcuccgcu ccucccggac cuuucgccug gccccucauu      180

ggcaacgcgg cugccguggg gcaagccgcu caucugucuu uugccagacu ugcucggcgc      240

uacggagaug uguuccagau cagacugggc agcugcccua uugucgugcu caauggggag      300

cgggccaucc accaggcgcu gguucagcaa ggauccgccu uugcugaccg cccggccuuc      360

gcuucuuuua gaguggucag cggcggccgg uccauggccu ucgggcauua uagcgaacac      420

uggaaggugc agcgcagagc ggcccauucu augaugcgga acuuuuucac acgccagccc      480

agaucccggc agguucuuga gggacacgug cugagcgaag cuagagagcu cgucgcccug      540

cuggugcgcg gcucugcuga uggggccuuu cucgacccuc ggccccugac cguggucgcc      600

guugcuaaug ugauguccgc gguguguuuc ggaugcagau acagccacga ugacccugaa      660

uuucgcgagc uucugucuca uaacgaggag uucggccgga cagucggggc cggaucccuc      720

guggauguua ugcccuggcu gcaauauuuu ccgaauccug ugagaaccgu cuuccgcgag      780

uucgaacagc uuaaccggaa uuuuagcaac uucauucugg acaaauuucu cagacacugu      840

gagucccugc gccccggcgc ugccccucgg gauaugaugg acgccuucau ccugucugcu      900

gagaagaaag ccgcgggcga uagccauggg ggaggcgcua gacucgaccu ggaaaaugug      960

cccgccacaa ucaccgauau uuuuggggcc ucccaggaca cgcuuagcac cgcucugcaa     1020

uggcuccugc uucuguucac acgcuacccc gacguucaga cccgggugca ggccgagcuc     1080

gaucaggucg ugggaagaga ccggcugccu ugcaugggcg aucaaccgaa ccugcccuau     1140

guccucgcuu uucuguacga agccaugcgc uucucuuccu uugugccugu uacaaucccc     1200

cacgcgacca cggccaauac aagcgugcuu ggguaucaca uuccuaagga caccgucgug     1260

uucguuaacc aguggucugu gaaucaugau ccccugaaau ggccgaaccc ugagaacuuu     1320

gaccccgcua gauuccucga uaaggacgga cugaucaaua aggaucugac aagccggguc     1380

augauuuuua gcgugggcaa aagacgcugu aucggcgaag aacuuucuaa gaugcaacuc     1440

uuccuguuca uuagcauccu ggcccaccag ugcgacuuuc gggcuaaccc uaaugagccc     1500

gccaaaauga acuucuccua cgggcucacc aucaagccua aauccuuuaa ggugaauguu     1560

acccugagag aaucuaugga gcuucuggau uccgcggucc agaaccucca ggccaaggaa     1620

acaugucagu ga                                                         1632


<210>  1140
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CSAG2__Homo_sapiens__Q9Y5P2-2

<400>  1140

Met Trp Met Gly Leu Ile Gln Leu Val Glu Gly Val Lys Arg Lys Asp 
1               5                   10                  15      


Gln Gly Phe Leu Glu Lys Glu Phe Tyr His Lys Thr Asn Ile Lys Met 
            20                  25                  30          


Arg Cys Glu Phe Leu Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Arg Asp Gln Val Asp Trp Ser Arg Leu Leu Arg Asp Ala Gly 
    50                  55                  60                  


Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn 
65                  70                  75                  80  


Asn His Pro Pro Thr Pro Lys Arg Phe Pro Arg Gln Pro Gly Arg Glu 
                85                  90                  95      


Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro 
            100                 105                 110 


<210>  1141
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CSAG2__Homo_sapiens__NM_001129828

<400>  1141
auguggaugg gccucaucca auuaguugaa gguguuaaga gaaaagacca agguuuccug       60

gaaaaggaau ucuaccacaa gacuaacaua aaaaugcgcu gugaguuucu agccugcugg      120

ccugccuuca cuguccuggg ggaggcuugg agagaccagg uggacuggag uagacuguug      180

agagacgcug gucuggugaa gauguccagg aaaccacgag ccuccagccc auuguccaac      240

aaccacccac caacaccaaa gagguuccca agacaacccg gaagggaaaa gggacccauc      300

aaggaaguuc caggaacaaa aggcucuccc uaa                                   333


<210>  1142
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CSAG2__Homo_sapiens__NM_001129828

<400>  1142
auguggaugg gccugaucca gcucguggag ggggucaagc gcaaggacca gggcuuccug       60

gagaaggagu ucuaccacaa gaccaacauc aagaugcggu gcgaguuccu ggccugcugg      120

cccgccuuca ccgugcucgg ggaggcgugg cgcgaccagg uggacuggag ccggcugcug      180

cgcgacgccg gccucgucaa gaugucccgg aagccgcgcg ccagcagccc ccuguccaac      240

aaccacccgc ccacgcccaa gcgguucccc cgccagcccg ggcgggagaa gggccccauc      300

aaggaggugc cgggcaccaa gggguccccc uga                                   333


<210>  1143
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CSAG2__Homo_sapiens__NM_001129828

<400>  1143
auguggaugg gccucaucca gcucgucgag ggcgucaagc gcaaggacca gggcuuccuc       60

gagaaggagu ucuaccacaa gaccaacauc aagaugcgcu gcgaguuccu cgccugcugg      120

cccgccuuca ccguccucgg cgaggccugg cgcgaccagg ucgacugguc ccgccuccuc      180

cgcgacgccg gccucgucaa gaugucccgc aagccccgcg ccuccucccc ccucuccaac      240

aaccaccccc ccacccccaa gcgcuucccc cgccagcccg gccgcgagaa gggccccauc      300

aaggaggucc ccggcaccaa gggcuccccc uga                                   333


<210>  1144
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CSAG2__Homo_sapiens__NM_001129828

<400>  1144
auguggaugg gccugaucca gcucguggag ggggucaaga gaaaagacca aggauuccuu       60

gaaaaggagu uuuaccacaa aaccaacauu aagaugaggu gcgaguuccu ggccuguugg      120

cccgcuuuua caguuuuggg ugaagcaugg cgggaucagg uggacuggag ccgcuuacug      180

cgagaugccg gccuaguaaa aaugucccgu aagccuagag cgucuucacc acucaguaau      240

aaccauccgc ccacuccuaa gagguuccca cggcagcccg ggcgcgaaaa aggaccuaua      300

aaggaggugc caggcacgaa agguagcccc uga                                   333


<210>  1145
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CSAG2__Homo_sapiens__NM_001129828

<400>  1145
auguggaugg gccugaucca gcugguggag ggcgugaaga gaaaggacca gggcuuccug       60

gagaaggagu ucuaccacaa gaccaacauc aagaugagau gcgaguuccu ggccugcugg      120

cccgccuuca ccgugcuggg cgaggccugg agagaccagg uggacuggag cagacugcug      180

agagacgccg gccuggugaa gaugagcaga aagcccagag ccagcagccc ccugagcaac      240

aaccaccccc ccacccccaa gagauucccc agacagcccg gcagagagaa gggccccauc      300

aaggaggugc ccggcaccaa gggcagcccc uga                                   333


<210>  1146
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CSAG2__Homo_sapiens__NM_001129828

<400>  1146
auguggaugg gccugaucca gcucguggag ggggucaaga gaaaagacca aggauuccug       60

gaaaaggagu uuuaccacaa aaccaacauu aagaugcggu gcgaguuccu ugccuguugg      120

cccgcuuuua caguucuggg cgaagccugg cgcgaucagg uggacuggag cagacuccug      180

cgggaugcgg ggcuugugaa aaugucccgc aagccuagag cuucuagccc gcuguccaau      240

aaccaucccc cuacgcccaa gcgguucccu cgccagcccg gaagagaaaa aggcccuauc      300

aaggaggucc cggggaccaa aggaucuccc uga                                   333


<210>  1147
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CSAG2__Homo_sapiens__Q9Y5P2

<400>  1147

Met Trp Met Gly Leu Ile Gln Leu Val Glu Gly Val Lys Arg Lys Asp 
1               5                   10                  15      


Gln Gly Phe Leu Glu Lys Glu Phe Tyr His Lys Thr Asn Ile Lys Met 
            20                  25                  30          


Arg Cys Glu Phe Leu Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Arg Asp Gln Val Asp Trp Ser Arg Leu Leu Arg Asp Ala Gly 
    50                  55                  60                  


Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn 
65                  70                  75                  80  


Asn His Pro Pro Thr Pro Lys Arg Arg Gly Ser Gly Arg His Pro Leu 
                85                  90                  95      


Asn Pro Gly Pro Glu Ala Leu Ser Lys Phe Pro Arg Gln Pro Gly Arg 
            100                 105                 110         


Glu Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro 
        115                 120                 125         


<210>  1148
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CSAG2__Homo_sapiens__NM_001129826

<400>  1148
auguggaugg gccucaucca auuaguugaa gguguuaaga gaaaagacca agguuuccug       60

gaaaaggaau ucuaccacaa gacuaacaua aaaaugcgcu gugaguuucu agccugcugg      120

ccugccuuca cuguccuggg ggaggcuugg agagaccagg uggacuggag uagacuguug      180

agagacgcug gucuggugaa gauguccagg aaaccacgag ccuccagccc auuguccaac      240

aaccacccac caacaccaaa gaggcgagga aguggaaggc auccucucaa cccuggccca      300

gaagcccuau caaaguuccc aagacaaccc ggaagggaaa agggacccau caaggaaguu      360

ccaggaacaa aaggcucucc cuaa                                             384


<210>  1149
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CSAG2__Homo_sapiens__NM_001129826

<400>  1149
auguggaugg gccugaucca gcucguggag ggggucaagc gcaaggacca gggcuuccug       60

gagaaggagu ucuaccacaa gaccaacauc aagaugcggu gcgaguuccu ggccugcugg      120

cccgccuuca ccgugcucgg ggaggcgugg cgcgaccagg uggacuggag ccggcugcug      180

cgcgacgccg gccucgucaa gaugucccgg aagccgcgcg ccagcagccc ccuguccaac      240

aaccacccgc ccacgcccaa gcggcgcggg uccggccggc acccccugaa ccccggcccc      300

gaggcccuca gcaaguuccc gcgccagccc gggcgggaga agggccccau caaggaggug      360

cccgggacca agggcucccc guga                                             384


<210>  1150
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CSAG2__Homo_sapiens__NM_001129826

<400>  1150
auguggaugg gccucaucca gcucgucgag ggcgucaagc gcaaggacca gggcuuccuc       60

gagaaggagu ucuaccacaa gaccaacauc aagaugcgcu gcgaguuccu cgccugcugg      120

cccgccuuca ccguccucgg cgaggccugg cgcgaccagg ucgacugguc ccgccuccuc      180

cgcgacgccg gccucgucaa gaugucccgc aagccccgcg ccuccucccc ccucuccaac      240

aaccaccccc ccacccccaa gcgccgcggc uccggccgcc acccccucaa ccccggcccc      300

gaggcccucu ccaaguuccc ccgccagccc ggccgcgaga agggccccau caaggagguc      360

cccggcacca agggcucccc cuga                                             384


<210>  1151
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CSAG2__Homo_sapiens__NM_001129826

<400>  1151
auguggaugg gccugaucca gcucguggag ggggucaaga gaaaagacca aggauuccuu       60

gaaaaggagu uuuaccacaa aaccaacauu aagaugaggu gcgaguuccu ggccuguugg      120

cccgcuuuua caguuuuggg ugaagcaugg cgggaucagg uggacuggag ccgcuuacug      180

cgagaugccg gccuaguaaa aaugucccgu aagccuagag cgucuucacc acucaguaau      240

aaccauccgc ccacuccuaa gaggcggggg agcggacgcc acccacugaa ucccggcccu      300

gaagcucuuu ccaaauuccc aagacagccc gguagggaga aggggccuau aaaagaggug      360

ccaggaacga agggcucucc guga                                             384


<210>  1152
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CSAG2__Homo_sapiens__NM_001129826

<400>  1152
auguggaugg gccugaucca gcugguggag ggcgugaaga gaaaggacca gggcuuccug       60

gagaaggagu ucuaccacaa gaccaacauc aagaugagau gcgaguuccu ggccugcugg      120

cccgccuuca ccgugcuggg cgaggccugg agagaccagg uggacuggag cagacugcug      180

agagacgccg gccuggugaa gaugagcaga aagcccagag ccagcagccc ccugagcaac      240

aaccaccccc ccacccccaa gagaagaggc agcggcagac acccccugaa ccccggcccc      300

gaggcccuga gcaaguuccc cagacagccc ggcagagaga agggccccau caaggaggug      360

cccggcacca agggcagccc cuga                                             384


<210>  1153
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CSAG2__Homo_sapiens__NM_001129826

<400>  1153
auguggaugg gccugaucca gcucguggag ggggucaaga gaaaagacca aggauuccug       60

gaaaaggagu uuuaccacaa aaccaacauu aagaugcggu gcgaguuccu ugccuguugg      120

cccgcuuuua caguucuggg cgaagccugg cgcgaucagg uggacuggag cagacuccug      180

cgggaugcgg ggcuugugaa aaugucccgc aagccuagag cuucuagccc gcuguccaau      240

aaccaucccc cuacgcccaa gcggcgcgga ucuggcagac acccucucaa ucccgggccu      300

gaagcccuga gcaaauuccc gcggcagccc ggacgcgaga agggcccuau caaagagguc      360

cccggcacca aggggucccc uuga                                             384


<210>  1154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT45A1__Homo_sapiens__Q5HYN5

<400>  1154

Met Thr Asp Lys Thr Glu Lys Val Ala Val Asp Pro Glu Thr Val Phe 
1               5                   10                  15      


Lys Arg Pro Arg Glu Cys Asp Ser Pro Ser Tyr Gln Lys Arg Gln Arg 
            20                  25                  30          


Met Ala Leu Leu Ala Arg Lys Gln Gly Ala Gly Asp Ser Leu Ile Ala 
        35                  40                  45              


Gly Ser Ala Met Ser Lys Ala Lys Lys Leu Met Thr Gly His Ala Ile 
    50                  55                  60                  


Pro Pro Ser Gln Leu Asp Ser Gln Ile Asp Asp Phe Thr Gly Phe Ser 
65                  70                  75                  80  


Lys Asp Arg Met Met Gln Lys Pro Gly Ser Asn Ala Pro Val Gly Gly 
                85                  90                  95      


Asn Val Thr Ser Ser Phe Ser Gly Asp Asp Leu Glu Cys Arg Glu Thr 
            100                 105                 110         


Ala Ser Ser Pro Lys Ser Gln Arg Glu Ile Asn Ala Asp Ile Lys Arg 
        115                 120                 125             


Lys Leu Val Lys Glu Leu Arg Cys Val Gly Gln Lys Tyr Glu Lys Ile 
    130                 135                 140                 


Phe Glu Met Leu Glu Gly Val Gln Gly Pro Thr Ala Val Arg Lys Arg 
145                 150                 155                 160 


Phe Phe Glu Ser Ile Ile Lys Glu Ala Ala Arg Cys Met Arg Arg Asp 
                165                 170                 175     


Phe Val Lys His Leu Lys Lys Lys Leu Lys Arg Met Ile 
            180                 185                 


<210>  1155
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CT45A1__Homo_sapiens__AAI40914

<400>  1155
augaccgaua aaacagagaa gguggcugua gauccugaaa cuguguuuaa acgucccagg       60

gaaugugaca guccuucgua ucagaaaagg cagaggaugg cccuguuggc aaggaaacaa      120

ggagcaggag acagccuuau ugcaggcucu gccaugucca aagcaaagaa gcuuaugaca      180

ggacaugcua uuccacccag ccaauuggau ucucagauug augacuucac ugguuucagc      240

aaagauagga ugaugcagaa accugguagc aaugcaccug ugggaggaaa cguuaccagc      300

aguuucucug gagaugaccu agaaugcaga gaaacagccu ccucucccaa aagccaacga      360

gaaauuaaug cugauauaaa acguaaauua gugaaggaac uccgaugcgu uggacaaaaa      420

uaugaaaaaa ucuucgaaau gcuugaagga gugcaaggac cuacugcagu caggaagcga      480

uuuuuugaau ccaucaucaa ggaagcagca agauguauga gacgagacuu uguuaagcac      540

cuuaagaaga aacugaaacg uaugauuuga                                       570


<210>  1156
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CT45A1__Homo_sapiens__AAI40914

<400>  1156
augaccgaca agaccgagaa gguggccguc gaccccgaga cgguguucaa gcgcccgcgg       60

gagugcgaca gccccuccua ccagaagcgc cagcggaugg cccugcucgc gcgcaagcag      120

ggcgccgggg acagccugau cgccggcucc gccaugagca aggccaagaa gcugaugacc      180

gggcacgcga ucccgcccuc ccagcucgac agccagaucg acgacuucac cggcuucucc      240

aaggaccgga ugaugcagaa gcccgggagc aacgcccccg ugggcggcaa cgucaccucc      300

agcuucuccg gggacgaccu ggagugccgc gagacggcca gcucccccaa gagccagcgg      360

gagaucaacg ccgacaucaa gcgcaagcug gugaaggagc uccggugcgu gggccagaag      420

uacgagaaga ucuucgagau gcuggagggg guccagggcc ccaccgcggu gcgcaagcgg      480

uucuucgagu ccaucaucaa ggaggccgcc cgcugcaugc ggcgcgacuu cgugaagcac      540

cugaagaaga agcucaagcg gaugaucuga                                       570


<210>  1157
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CT45A1__Homo_sapiens__AAI40914

<400>  1157
augaccgaca agaccgagaa ggucgccguc gaccccgaga ccgucuucaa gcgcccccgc       60

gagugcgacu cccccuccua ccagaagcgc cagcgcaugg cccuccucgc ccgcaagcag      120

ggcgccggcg acucccucau cgccggcucc gccaugucca aggccaagaa gcucaugacc      180

ggccacgcca ucccccccuc ccagcucgac ucccagaucg acgacuucac cggcuucucc      240

aaggaccgca ugaugcagaa gcccggcucc aacgcccccg ucggcggcaa cgucaccucc      300

uccuucuccg gcgacgaccu cgagugccgc gagaccgccu ccucccccaa gucccagcgc      360

gagaucaacg ccgacaucaa gcgcaagcuc gucaaggagc uccgcugcgu cggccagaag      420

uacgagaaga ucuucgagau gcucgagggc guccagggcc ccaccgccgu ccgcaagcgc      480

uucuucgagu ccaucaucaa ggaggccgcc cgcugcaugc gccgcgacuu cgucaagcac      540

cucaagaaga agcucaagcg caugaucuga                                       570


<210>  1158
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CT45A1__Homo_sapiens__AAI40914

<400>  1158
augaccgaca agacagagaa aguggccguc gaucccgaaa cuguuuucaa gagaccuagg       60

gagugcgaca gcccauccua ccagaaacgg caacgcaugg cucugcucgc acgaaagcag      120

ggcgccgggg auucucuuau cgcgggauca gcuaugagua aagccaagaa gcugaugacg      180

ggucacgcaa uuccgcccag ccaguuggac ucccagauag augacuuuac cggcuucucu      240

aaagaucgua ugaugcaaaa gccugggucg aacgccccag ugggaggcaa uguaacaagc      300

ucauuuagug gugacgauuu agaauguaga gagacugcuu ccucucccaa aagccagagg      360

gaaaucaacg cagacauuaa gcggaaacug gugaaggagc uacgcugcgu cgggcagaag      420

uaugagaaaa ucuucgaaau gcucgaggga gugcagggcc cuaccgccgu uagaaagagg      480

uuuuucgaau ccauuaucaa agaggcugcc cgguguaugc gccgagauuu ugugaagcau      540

cugaaaaaga aacuuaagag aaugauauga                                       570


<210>  1159
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CT45A1__Homo_sapiens__AAI40914

<400>  1159
augaccgaca agaccgagaa gguggccgug gaccccgaga ccguguucaa gagacccaga       60

gagugcgaca gccccagcua ccagaagaga cagagaaugg cccugcuggc cagaaagcag      120

ggcgccggcg acagccugau cgccggcagc gccaugagca aggccaagaa gcugaugacc      180

ggccacgcca ucccccccag ccagcuggac agccagaucg acgacuucac cggcuucagc      240

aaggacagaa ugaugcagaa gcccggcagc aacgcccccg ugggcggcaa cgugaccagc      300

agcuucagcg gcgacgaccu ggagugcaga gagaccgcca gcagccccaa gagccagaga      360

gagaucaacg ccgacaucaa gagaaagcug gugaaggagc ugagaugcgu gggccagaag      420

uacgagaaga ucuucgagau gcuggagggc gugcagggcc ccaccgccgu gagaaagaga      480

uucuucgaga gcaucaucaa ggaggccgcc agaugcauga gaagagacuu cgugaagcac      540

cugaagaaga agcugaagag aaugaucuga                                       570


<210>  1160
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CT45A1__Homo_sapiens__AAI40914

<400>  1160
augaccgaca agacagagaa aguggccguc gaucccgaaa cgguuuucaa gagaccucgg       60

gagugcgaca gcccguccua ccagaaacgc caaagaaugg cucugcucgc ccggaagcag      120

ggcgcggggg auucucugau cgcuggaagc gccaugucca aagccaagaa acuuaugacc      180

ggccacgcua uucccccuuc ucagcuggac agccagaucg augacuuuac aggguucucc      240

aaggaucgca ugaugcaaaa gcccggaucu aacgccccug ugggcgggaa ugugaccagc      300

uccuuuagcg gagacgaucu cgaauguaga gagacagcuu cuucccccaa aagccagcgg      360

gaaauuaacg ccgacaucaa gcgcaaacug gucaaggagc uuagaugcgu gggccagaag      420

uaugagaaaa uuuucgaaau gcuggagggc guucaggggc cuaccgcggu gcggaagcgc      480

uuuuucgaau cuaucaucaa agaggccgcu agauguaugc ggcgcgauuu ugucaagcau      540

cucaaaaaga aacugaagag aaugauuuga                                       570


<210>  1161
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT55__Homo_sapiens__Q8WUE5

<400>  1161

Met Leu Arg Leu Leu Arg Leu Ala Leu Ala Phe Tyr Gly Arg Thr Ala 
1               5                   10                  15      


Asp Pro Ala Glu Arg Gln Gly Pro Gln Gln Gln Gly Leu Pro Gln Gly 
            20                  25                  30          


Asp Thr Gln Leu Thr Thr Val Gln Gly Val Val Thr Ser Phe Cys Gly 
        35                  40                  45              


Asp Tyr Gly Met Ile Asp Glu Ser Ile Tyr Phe Ser Ser Asp Val Val 
    50                  55                  60                  


Thr Gly Asn Val Pro Leu Lys Val Gly Gln Lys Val Asn Val Val Val 
65                  70                  75                  80  


Glu Glu Asp Lys Pro His Tyr Gly Leu Arg Ala Ile Lys Val Asp Val 
                85                  90                  95      


Val Pro Arg His Leu Tyr Gly Ala Gly Pro Ser Asp Ser Gly Thr Arg 
            100                 105                 110         


Val Leu Ile Gly Cys Val Thr Ser Ile Asn Glu Asp Asn Ile Tyr Ile 
        115                 120                 125             


Ser Asn Ser Ile Tyr Phe Ser Ile Ala Ile Val Ser Glu Asp Phe Val 
    130                 135                 140                 


Pro Tyr Lys Gly Asp Leu Leu Glu Val Glu Tyr Ser Thr Glu Pro Gly 
145                 150                 155                 160 


Ile Ser Asn Ile Lys Ala Thr Ser Val Lys Pro Ile Arg Cys Ile His 
                165                 170                 175     


Thr Glu Glu Val Cys Ile Thr Ser Val His Gly Arg Asn Gly Val Ile 
            180                 185                 190         


Asp Tyr Thr Ile Phe Phe Thr Leu Asp Ser Val Lys Leu Pro Asp Gly 
        195                 200                 205             


Tyr Val Pro Gln Val Asp Asp Ile Val Asn Val Val Met Val Glu Ser 
    210                 215                 220                 


Ile Gln Phe Cys Phe Ile Trp Arg Ala Ile Ser Ile Thr Pro Val His 
225                 230                 235                 240 


Lys Ser Ser Ser Gly Phe Gln Asp Asp Gly Gly Leu Gly Arg Pro Lys 
                245                 250                 255     


Arg Glu Arg Arg Ser Gln Ser Ile 
            260                 


<210>  1162
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CT55__Homo_sapiens__AAH20662

<400>  1162
augcucaggc uucugagacu ugcuuuggcc uucuacggga ggacggccga cccugcagag       60

cgacagggcc cacagcagca gggccuccca caaggugaca cccaguugac aacugugcag      120

ggaguuguca caaguuucug uggugauuau ggcaugauug augagucgau cuacuucagu      180

agugauguug ugacuggcaa cgugccucua aaaguuggac aaaaaguuaa ugugguugug      240

gaagaagaua aaccacauua uggauugaga gcaaucaagg uggauguugu gccucgccau      300

cuuuauggug cuggacccuc agacucagga accagaguuu uaauuggaug uguuacuucu      360

auaaaugaag auaauauuua uauuaguaac agcauuuauu uuuccauagc cauuguuucu      420

gaagauuuug ugccuuauaa gggugacuug uuagaaguug aauauuccac ugagccaggc      480

aucucaaaca ucaaggcaac uucugugaag cccauccguu guauucauac ggaagagguc      540

ugcauuacua gcguacaugg aagaaauggg gugauagauu auacuauuuu uuucaccuug      600

gauucuguga aacuuccuga uggauacgua ccucaaguag augauaucgu caaugugguc      660

augguggaga gcauucaguu cugcuuuauu uggagagcga uuucuaucac cccagugcau      720

aaauccagca gcggauucca ggaugacgga ggccugggac ggcccaaaag ggaacgucgg      780

agccaaagca uuuaa                                                       795


<210>  1163
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CT55__Homo_sapiens__AAH20662

<400>  1163
augcugcgcc uccugcggcu ggcccucgcc uucuacggcc gcaccgcgga ccccgccgag       60

cggcaggggc cgcagcagca gggccugccc cagggggaca cccagcugac gaccgugcag      120

ggcgucguga ccagcuucug cggggacuac ggcaugaucg acgaguccau cuacuucagc      180

uccgacgugg ucaccggcaa cgugccccuc aagguggggc agaaggucaa cguggugguc      240

gaggaggaca agccccacua cggccugcgc gccaucaagg uggacguggu cccgcggcac      300

cuguacgggg ccggccccag cgacuccggg acgcgcgugc ucaucggcug cgugaccagc      360

aucaacgagg acaacaucua caucuccaac agcaucuacu ucuccaucgc caucgucagc      420

gaggacuucg ugcccuacaa gggcgaccug cuggaggugg aguacuccac cgagcccggg      480

aucagcaaca ucaaggcgac cuccgucaag ccgauccggu gcauccacac ggaggaggug      540

ugcaucacca gcgugcacgg ccgcaacggg gucaucgacu acaccaucuu cuucacccuc      600

gacuccguga agcugcccga cggcuacgug ccccaggucg acgacaucgu gaacgucgug      660

augguggaga gcauccaguu cugcuucauc uggcgggcca ucuccaucac gcccguccac      720

aagagcucca gcggcuucca ggacgacggg ggccuggggc gcccgaagcg ggagcgccgg      780

agccagucca ucuga                                                       795


<210>  1164
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CT55__Homo_sapiens__AAH20662

<400>  1164
augcuccgcc uccuccgccu cgcccucgcc uucuacggcc gcaccgccga ccccgccgag       60

cgccagggcc cccagcagca gggccucccc cagggcgaca cccagcucac caccguccag      120

ggcgucguca ccuccuucug cggcgacuac ggcaugaucg acgaguccau cuacuucucc      180

uccgacgucg ucaccggcaa cgucccccuc aaggucggcc agaaggucaa cgucgucguc      240

gaggaggaca agccccacua cggccuccgc gccaucaagg ucgacgucgu cccccgccac      300

cucuacggcg ccggccccuc cgacuccggc acccgcgucc ucaucggcug cgucaccucc      360

aucaacgagg acaacaucua caucuccaac uccaucuacu ucuccaucgc caucgucucc      420

gaggacuucg uccccuacaa gggcgaccuc cucgaggucg aguacuccac cgagcccggc      480

aucuccaaca ucaaggccac cuccgucaag cccauccgcu gcauccacac cgaggagguc      540

ugcaucaccu ccguccacgg ccgcaacggc gucaucgacu acaccaucuu cuucacccuc      600

gacuccguca agcuccccga cggcuacguc ccccaggucg acgacaucgu caacgucguc      660

auggucgagu ccauccaguu cugcuucauc uggcgcgcca ucuccaucac ccccguccac      720

aaguccuccu ccggcuucca ggacgacggc ggccucggcc gccccaagcg cgagcgccgc      780

ucccagucca ucuga                                                       795


<210>  1165
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CT55__Homo_sapiens__AAH20662

<400>  1165
augcugagac uccuuaggcu ggccuuggcu uucuacggcc ggaccgcaga ccccgccgag       60

cgccaggggc cucaacagca gggauuacca cagggugaua cacaacugac uacggugcag      120

ggcgucguua ccagcuuuug cggggacuau ggaaugaucg augaauccau uuacuucucu      180

ucagacgugg uaacaggcaa cgugccgcua aaggucgguc agaaagugaa uguugugguc      240

gaggaagaua agccccacua ugggcuccga gcgauaaaag uggacguagu uccucgucau      300

cuguacggag cuggcccaag ugauagcggc acuagagugc uuaucgggug ugucaccucc      360

auuaacgagg acaauaucua uauuucuaac ucgaucuacu uuucaauagc caucgugagc      420

gaagauuucg ugcccuauaa gggagaccug uuggaggucg aguacaguac agaaccuggu      480

auuuccaaua ucaaagcaac cucuguuaag ccaauuaggu gcauccacac ugaggaagug      540

uguauaacaa gcguacaugg ccggaacggg gugauugauu acaccaucuu uuucacgcuc      600

gacuccguca agcugcccga uggauaugug ccucagguug acgacauugu gaaugucgug      660

augguagagu caauccaauu uugcuucauc uggcgcgcca uuaguauaac uccaguucac      720

aaaucuagcu ccggcuuuca ggaugacggu gggcugggaa gaccgaagag ggagcggcgc      780

ucacagagca ucuga                                                       795


<210>  1166
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CT55__Homo_sapiens__AAH20662

<400>  1166
augcugagac ugcugagacu ggcccuggcc uucuacggca gaaccgccga ccccgccgag       60

agacagggcc cccagcagca gggccugccc cagggcgaca cccagcugac caccgugcag      120

ggcgugguga ccagcuucug cggcgacuac ggcaugaucg acgagagcau cuacuucagc      180

agcgacgugg ugaccggcaa cgugccccug aaggugggcc agaaggugaa cgugguggug      240

gaggaggaca agccccacua cggccugaga gccaucaagg uggacguggu gcccagacac      300

cuguacggcg ccggccccag cgacagcggc accagagugc ugaucggcug cgugaccagc      360

aucaacgagg acaacaucua caucagcaac agcaucuacu ucagcaucgc caucgugagc      420

gaggacuucg ugcccuacaa gggcgaccug cuggaggugg aguacagcac cgagcccggc      480

aucagcaaca ucaaggccac cagcgugaag cccaucagau gcauccacac cgaggaggug      540

ugcaucacca gcgugcacgg cagaaacggc gugaucgacu acaccaucuu cuucacccug      600

gacagcguga agcugcccga cggcuacgug ccccaggugg acgacaucgu gaacguggug      660

augguggaga gcauccaguu cugcuucauc uggagagcca ucagcaucac ccccgugcac      720

aagagcagca gcggcuucca ggacgacggc ggccugggca gacccaagag agagagaaga      780

agccagagca ucuga                                                       795


<210>  1167
<211>  795
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CT55__Homo_sapiens__AAH20662

<400>  1167
augcugagac uccugcggcu ugcccuggcu uucuacggcc gcaccgccga ccccgcggag       60

agacaggggc cucaacagca gggacucccg cagggcgaua cacaacugac gaccgugcag      120

ggggucguua ccagcuuuug cggagacuau ggcaugaucg augaauccau uuacuucucu      180

agcgacgugg ugacagggaa cgucccccuu aaggugggac agaaaguuaa uguggucgug      240

gaggaagaua agccucacua uggccugcgg gcuaucaaag uugacguggu cccccgccau      300

cucuacggcg ccgggccuuc cgauucugga acaagagugc ugauuggcug ugugaccagc      360

aucaacgagg acaauauuua uaucuccaac ucuaucuacu uuagcauugc caucgucucc      420

gaagauuucg uucccuauaa gggggaccug cucgaggugg aguacagcac agaaccugga      480

auuucuaaua ucaaagcuac cuccgugaag ccgauucggu gcauccacac ggaggaaguc      540

uguauuacca gcgugcaugg ccgcaacggg guuaucgauu acacaaucuu uuucacccug      600

gacucuguga aacuucccga uggauauguc ccucaggugg acgacauugu uaaugugguc      660

augguggagu ccauccaauu uugcuucauu uggagagcca ucagcauuac acccguccac      720

aagucuucca gcggcuuuca ggaugacggc gggcugggac ggccuaagcg cgagagacgg      780

ucccagucua ucuga                                                       795


<210>  1168
<211>  947
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CT-_9/BRD6__Homo_sapiens__Q58F21

<400>  1168

Met Ser Leu Pro Ser Arg Gln Thr Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Thr Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Thr Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Thr Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Thr Ala Ala Gln Val Thr 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Ala Thr Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Thr Phe Thr Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Thr Val Lys Val Thr Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Thr His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Thr Asp Ile Thr Glu Thr Thr Gly Arg Glu 
385                 390                 395                 400 


Asn Thr Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu Lys Val 
    450                 455                 460                 


Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln Gln Phe 
                485                 490                 495     


Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met Asn Tyr 
            500                 505                 510         


Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro Gly Asp 
        515                 520                 525             


Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu 
    530                 535                 540                 


Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys 
545                 550                 555                 560 


Ala Ser Thr Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys Leu Arg 
                565                 570                 575     


Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser Lys Glu 
            580                 585                 590         


Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu Leu Asp 
        595                 600                 605             


Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Thr Lys Ser Asp Lys 
    610                 615                 620                 


Thr Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser Glu Ser 
625                 630                 635                 640 


Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser Ser Asp 
                645                 650                 655     


Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe Pro Lys 
            660                 665                 670         


Phe Thr Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn Val Lys 
        675                 680                 685             


Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg Thr Gly Val Thr 
    690                 695                 700                 


Gln Ile Gly Tyr Cys Val Gln Asp Thr Thr Ser Ala Asn Thr Thr Leu 
705                 710                 715                 720 


Val His Gln Thr Thr Pro Ser His Val Met Pro Pro Asn His His Gln 
                725                 730                 735     


Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Thr Val Lys Asn 
            740                 745                 750         


Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu Gln Leu 
        755                 760                 765             


Ser Asn Gly Ile Thr Val Met His Pro Ser Gly Asp Ser Asp Thr Thr 
    770                 775                 780                 


Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile Lys Ile 
785                 790                 795                 800 


Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys Pro Ser 
                805                 810                 815     


Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg Lys Ala 
            820                 825                 830         


Ala Ile Glu Lys Glu Val Lys Ala Arg Thr Gln Glu Leu Ile Arg Lys 
        835                 840                 845             


His Leu Glu Gln Asn Thr Lys Glu Leu Lys Ala Ser Gln Glu Asn Gln 
    850                 855                 860                 


Arg Asp Leu Gly Asn Gly Leu Thr Val Glu Ser Phe Ser Asn Lys Ile 
865                 870                 875                 880 


Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln Ser Ser 
                885                 890                 895     


Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg Asp Leu 
            900                 905                 910         


Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Val Gly 
        915                 920                 925             


Thr Ile Asp Met Thr Leu Gln Ser Asp Ile Met Thr Met Phe Glu Asn 
    930                 935                 940                 


Asn Phe Asp 
945         


<210>  1169
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1169
augucucugc caagucgaca aacagcuauu auuguuaacc cuccuccacc agaauauaua       60

aauacuaaga aaaaugggcg auugacaaau caacuucagu aucuacaaaa aguuguccua      120

aaggauuuau ggaagcauag uuuuucaugg cccuuucaac guccugugga ugcugugaaa      180

cuacaguugc cugauuauua uaccauuaua aaaaacccaa uggauuuaaa uacaauuaag      240

aagcgcuugg agaauaaaua uuaugcgaag gcuucagaau guauagaaga cuucaauaca      300

auguucucaa auuguuauuu auauaacaag ccuggagaug acauuguucu uauggcacaa      360

gcucuagaga agcuguuuau gcagaaauua ucucagaugc cacaagaaga gcaaguugug      420

gguguuaagg aaagaaucaa gaaaggcacu caacagaaua uagcuguuuc uucugcuaaa      480

gaaaaaucau cacccagcgc aacagaaaaa guauuuaagc agcaagaaau uccuucugua      540

uuuccuaaga caucuauuuc ucccuugaac gugguacagg gagcuucagu caacuccagu      600

ucacaaacug cggcccaagu uacaaaaggu gugaagagga aagcagauac aacaacuccu      660

gcaacuucag caguuaaagc aaguagugaa uuuucuccaa cauucacaga aaaaucagug      720

gcacugccac cuauaaaaga aaauaugcca aagaauguuu ugccagauuc ucagcaacaa      780

uauaauguug ugaagacugu uaaaguaacu gaacaauuaa ggcacuguag ugagauucuu      840

aaagaaaugc uugcaaagaa acauuuuuca uaugcauggc ccuuuuauaa uccuguugac      900

guuaaugcuu ugggacucca uaacuacuau gacguuguca aaaauccgau ggaucuugga      960

acuauuaagg agaaaaugga uaaccaagaa uauaaggaug cauacaaauu ugcggcagau     1020

guuagauuaa uguucaugaa uugcuacaag uacaauccuc cagaucacga aguugugaca     1080

auggcaagaa ugcuucagga uguuuucgaa acgcauuuuu caaagauccc gauugaaccu     1140

guugagagua ugccuuuaug uuacaucaaa acagauauca cagaaaccac ugguagagag     1200

aacacuaaug aagccuccuc ugaagggaac ucuucugaug auucugaaga ugagcgaguu     1260

aagcgucuug caaagcuuca ggagcagcuu aaagcuguac aucaacagcu ccagguuuug     1320

ucccaaguac cuuuccguaa gcuaaauaaa aagaaagaga agucuaaaaa ggaaaagaaa     1380

aaagaaaagg uuaauaacag caaugaaaau ccaagaaaaa ugugugagca aaugaggcua     1440

aaggaaaagu ccaagagaaa ucagccaaag aaaaggaaac aacaguucau uggucuaaaa     1500

ucugaagaug aagauaaugc uaaaccuaug aacuaugaug agaaaaggca guuaagucug     1560

aauauaaaca aacucccugg agauaaacuu gggcgaguag uucacauaau acaaucaaga     1620

gagccuucuc ugagcaauuc caauccugau gagauagaga uagacuuuga aacacugaaa     1680

gcaucaacac uaagagaauu agaaaaauau guuucggcau gucuaagaaa gagaccauua     1740

aaaccuccug cuaagaaaau aaugaugucc aaagaagaac uucacucaca gaaaaaacag     1800

gaauuggaaa agcgguuacu ggauguuaau aaucaguuaa auucuagaaa acgucaaaca     1860

aaaucugaua aaacgcaacc auccaaagcu guugaaaaug uuucccgacu gagugagagc     1920

agcagcagca gcagcagcuc aucagagucu gaaaguagca gcagugacuu aagcucuuca     1980

gacagcagug auucugaauc agaaauguuc ccuaaguuua cagaaguaaa accaaaugau     2040

ucuccuucua aagagaaugu aaagaaaaug aagaaugaau gcauaccgcc ugaaggaaga     2100

acaggcguca cacagauagg auauugugug caagacacaa ccucugccaa uacuacccuu     2160

guucaucaga ccacaccuuc acauguaaug ccaccaaauc accaccaauu agcauuuaau     2220

uaucaagaau uagaacauuu acagacugug aaaaacauuu caccuuuaca aauucugccu     2280

cccucaggug auucugaaca gcucucaaau ggcauaacug ugaugcaucc aucuggugau     2340

agugacacaa cgauguuaga aucugaaugu caagcuccug uacagaagga uauaaagauu     2400

aagaaugcag auucauggaa aaguuuaggc aaaccaguga aaccaucagg uguaaugaaa     2460

uccucagaug agcucuucaa ccaauuuaga aaagcagcca uagaaaagga aguaaaagcu     2520

cggacacagg aacucauacg gaagcauuug gaacaaaaua caaaggaacu aaaagcaucu     2580

caagaaaauc agagggaucu ugggaaugga uugacuguag aaucuuuuuc aaauaaaaua     2640

caaaacaagu gcucuggaga agagcagaaa gaacaucagc agucaucaga agcucaagau     2700

aaauccaaac ucuggcuucu caaagaccgu gauuuagcaa ggcagaaaga acaagagagg     2760

aggaggagag aagcaauggu ggguaccauu gauaugaccc uucaaaguga cauuaugaca     2820

auguuugaaa acaacuuuga uuaa                                            2844


<210>  1170
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1170
augagccugc ccucccgcca gaccgccauc aucgugaacc cgcccccccc cgaguacauc       60

aacaccaaga agaacggccg gcucacgaac cagcugcagu accugcagaa ggucgugcuc      120

aaggaccugu ggaagcacag cuucuccugg ccguuccagc gccccgugga cgccgucaag      180

cugcagcucc ccgacuacua caccaucauc aagaacccca uggaccugaa caccaucaag      240

aagcggcugg agaacaagua cuacgcgaag gccagcgagu gcaucgagga cuucaacacc      300

auguucucca acugcuaccu cuacaacaag ccgggggacg acaucgugcu gauggcccag      360

gcccuggaga agcucuucau gcagaagcug agccagaugc cccaggagga gcaggugguc      420

ggcgugaagg agcgcaucaa gaaggggacg cagcagaaca ucgccguguc cagcgcgaag      480

gagaagucca gccccuccgc caccgagaag gucuucaagc agcaggagau ccccagcgug      540

uucccgaaga ccuccaucag cccccugaac gugguccagg gcgccuccgu gaacagcucc      600

agccagaccg ccgcgcaggu gacgaagggg gucaagcgga aggccgacac caccaccccc      660

gccacguccg ccgugaaggc cagcagcgag uucuccccca ccuucaccga gaagagcgug      720

gcgcucccgc ccaucaagga gaacaugccc aagaacgucc ugcccgacuc ccagcagcag      780

uacaacgugg ugaagaccgu caaggugacg gagcagcugc gccacugcag cgagauccuc      840

aaggagaugc uggccaagaa gcacuucucc uacgccuggc cguucuacaa ccccguggac      900

gucaacgccc ugggccucca caacuacuac gacgugguca agaaccccau ggaccugggc      960

accaucaagg agaagaugga caaccaggag uacaaggacg ccuacaaguu cgcggccgac     1020

gugcggcuga uguucaugaa cugcuacaag uacaaccccc cggaccacga gguggucacc     1080

auggcccgca ugcuccagga cguguucgag acccacuuca gcaagauccc caucgagccc     1140

guggagucca ugccccugug cuacaucaag acggacauca ccgagaccac cgggcgggag     1200

aacacgaacg aggccagcuc cgagggcaac agcuccgacg acagcgagga cgagcgcguc     1260

aagcggcugg ccaagcucca ggagcagcug aaggcggugc accagcagcu gcaggugcuc     1320

ucccaggucc cguuccgcaa gcugaacaag aagaaggaga agagcaagaa ggagaagaag     1380

aaggagaagg ugaacaacuc caacgagaac ccccggaaga ugugcgagca gaugcgccug     1440

aaggagaaga gcaagcggaa ccagcccaag aagcgcaagc agcaguucau cgggcucaag     1500

uccgaggacg aggacaacgc caagccgaug aacuacgacg agaagcggca gcugagccug     1560

aacaucaaca agcuccccgg cgacaagcug gggcgcgugg uccacaucau ccagucccgg     1620

gagcccagcc ugagcaacuc caaccccgac gagaucgaga ucgacuucga gacccucaag     1680

gccagcaccc ugcgcgagcu ggagaaguac guguccgccu gccuccggaa gcgcccgcug     1740

aagccccccg ccaagaagau caugaugagc aaggaggagc ugcacuccca gaagaagcag     1800

gagcucgaga agcgccugcu ggacgugaac aaccagcuca acagccggaa gcgccagacc     1860

aaguccgaca agacgcagcc cagcaaggcg gucgagaacg ugucccggcu gagcgagucc     1920

agcuccagcu ccagcuccag cagcgagucc gagagcucca gcuccgaccu gagcuccagc     1980

gacuccagcg acuccgagag cgagauguuc ccgaaguuca ccgaggugaa gcccaacgac     2040

ucccccagca aggagaacgu caagaagaug aagaacgagu gcaucccccc ggagggccgc     2100

accggcguga cccagaucgg guacugcgug caggacacga ccuccgccaa caccacccug     2160

guccaccaga cgacccccag ccacgugaug ccccccaacc accaccagcu cgccuucaac     2220

uaccaggagc uggagcaccu gcagaccgug aagaacaucu ccccgcucca gauccugccc     2280

cccagcggcg acuccgagca gcugagcaac gggaucaccg ucaugcaccc cagcggcgac     2340

uccgacacca cgaugcucga gagcgagugc caggccccgg ugcagaagga caucaagauc     2400

aagaacgcgg acuccuggaa gagccugggc aagcccguga agcccuccgg ggucaugaag     2460

agcuccgacg agcuguucaa ccaguuccgg aaggccgcca ucgagaagga ggugaaggcc     2520

cgcacccagg agcucauccg gaagcaccug gagcagaaca ccaaggagcu gaaggccagc     2580

caggagaacc agcgcgaccu cggcaacggg cugaccgugg aguccuucag caacaagauc     2640

cagaacaagu gcuccggcga ggagcagaag gagcaccagc agagcuccga ggcgcaggac     2700

aagagcaagc uguggcuccu gaaggaccgg gaccuggccc gccagaagga gcaggagcgg     2760

cgccggcgcg aggccauggu cgggacgauc gacaugaccc uccaguccga caucaugacc     2820

auguucgaga acaacuucga cuga                                            2844


<210>  1171
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1171
augucccucc ccucccgcca gaccgccauc aucgucaacc cccccccccc cgaguacauc       60

aacaccaaga agaacggccg ccucaccaac cagcuccagu accuccagaa ggucguccuc      120

aaggaccucu ggaagcacuc cuucuccugg cccuuccagc gccccgucga cgccgucaag      180

cuccagcucc ccgacuacua caccaucauc aagaacccca uggaccucaa caccaucaag      240

aagcgccucg agaacaagua cuacgccaag gccuccgagu gcaucgagga cuucaacacc      300

auguucucca acugcuaccu cuacaacaag cccggcgacg acaucguccu cauggcccag      360

gcccucgaga agcucuucau gcagaagcuc ucccagaugc cccaggagga gcaggucguc      420

ggcgucaagg agcgcaucaa gaagggcacc cagcagaaca ucgccgucuc cuccgccaag      480

gagaaguccu cccccuccgc caccgagaag gucuucaagc agcaggagau ccccuccguc      540

uuccccaaga ccuccaucuc cccccucaac gucguccagg gcgccuccgu caacuccucc      600

ucccagaccg ccgcccaggu caccaagggc gucaagcgca aggccgacac caccaccccc      660

gccaccuccg ccgucaaggc cuccuccgag uucuccccca ccuucaccga gaaguccguc      720

gcccuccccc ccaucaagga gaacaugccc aagaacgucc uccccgacuc ccagcagcag      780

uacaacgucg ucaagaccgu caaggucacc gagcagcucc gccacugcuc cgagauccuc      840

aaggagaugc ucgccaagaa gcacuucucc uacgccuggc ccuucuacaa ccccgucgac      900

gucaacgccc ucggccucca caacuacuac gacgucguca agaaccccau ggaccucggc      960

accaucaagg agaagaugga caaccaggag uacaaggacg ccuacaaguu cgccgccgac     1020

guccgccuca uguucaugaa cugcuacaag uacaaccccc ccgaccacga ggucgucacc     1080

auggcccgca ugcuccagga cgucuucgag acccacuucu ccaagauccc caucgagccc     1140

gucgagucca ugccccucug cuacaucaag accgacauca ccgagaccac cggccgcgag     1200

aacaccaacg aggccuccuc cgagggcaac uccuccgacg acuccgagga cgagcgcguc     1260

aagcgccucg ccaagcucca ggagcagcuc aaggccgucc accagcagcu ccagguccuc     1320

ucccaggucc ccuuccgcaa gcucaacaag aagaaggaga aguccaagaa ggagaagaag     1380

aaggagaagg ucaacaacuc caacgagaac ccccgcaaga ugugcgagca gaugcgccuc     1440

aaggagaagu ccaagcgcaa ccagcccaag aagcgcaagc agcaguucau cggccucaag     1500

uccgaggacg aggacaacgc caagcccaug aacuacgacg agaagcgcca gcucucccuc     1560

aacaucaaca agcuccccgg cgacaagcuc ggccgcgucg uccacaucau ccagucccgc     1620

gagcccuccc ucuccaacuc caaccccgac gagaucgaga ucgacuucga gacccucaag     1680

gccuccaccc uccgcgagcu cgagaaguac gucuccgccu gccuccgcaa gcgcccccuc     1740

aagccccccg ccaagaagau caugaugucc aaggaggagc uccacuccca gaagaagcag     1800

gagcucgaga agcgccuccu cgacgucaac aaccagcuca acucccgcaa gcgccagacc     1860

aaguccgaca agacccagcc cuccaaggcc gucgagaacg ucucccgccu cuccgagucc     1920

uccuccuccu ccuccuccuc cuccgagucc gaguccuccu ccuccgaccu cuccuccucc     1980

gacuccuccg acuccgaguc cgagauguuc cccaaguuca ccgaggucaa gcccaacgac     2040

ucccccucca aggagaacgu caagaagaug aagaacgagu gcaucccccc cgagggccgc     2100

accggcguca cccagaucgg cuacugcguc caggacacca ccuccgccaa caccacccuc     2160

guccaccaga ccacccccuc ccacgucaug ccccccaacc accaccagcu cgccuucaac     2220

uaccaggagc ucgagcaccu ccagaccguc aagaacaucu ccccccucca gauccucccc     2280

cccuccggcg acuccgagca gcucuccaac ggcaucaccg ucaugcaccc cuccggcgac     2340

uccgacacca ccaugcucga guccgagugc caggcccccg uccagaagga caucaagauc     2400

aagaacgccg acuccuggaa gucccucggc aagcccguca agcccuccgg cgucaugaag     2460

uccuccgacg agcucuucaa ccaguuccgc aaggccgcca ucgagaagga ggucaaggcc     2520

cgcacccagg agcucauccg caagcaccuc gagcagaaca ccaaggagcu caaggccucc     2580

caggagaacc agcgcgaccu cggcaacggc cucaccgucg aguccuucuc caacaagauc     2640

cagaacaagu gcuccggcga ggagcagaag gagcaccagc aguccuccga ggcccaggac     2700

aaguccaagc ucuggcuccu caaggaccgc gaccucgccc gccagaagga gcaggagcgc     2760

cgccgccgcg aggccauggu cggcaccauc gacaugaccc uccaguccga caucaugacc     2820

auguucgaga acaacuucga cuga                                            2844


<210>  1172
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1172
augagccugc ccuccagaca gaccgccauc auugugaacc cuccaccgcc cgaguacaua       60

aauacaaaga aaaacggcag gcucacuaau caacuucagu aucugcagaa ggucguuuug      120

aaagacuuau ggaagcacuc uuucucaugg ccuuuucagc ggccagugga ugcuguaaaa      180

cugcaacuac ccgacuacua uacgaucauu aagaacccua uggaucucaa uaccaucaag      240

aaacgccugg aaaacaagua cuaugcaaaa gccagugagu gcauugaaga cuucaauaca      300

auguuuagca acuguuaccu uuauaauaag ccaggggaug acaucgugcu gauggcgcag      360

gcuuuggaga aacucuucau gcagaagcug ucccagaugc cccaagaaga acaggucgug      420

ggaguuaagg agcgaaucaa aaaggguacu cagcagaaca uagccguguc uucggcaaaa      480

gaaaagucaa gcccuagugc caccgagaaa gucuuuaagc aacaggaaau uccauccgug      540

uucccgaaaa caucuaucag cccccugaau guaguucagg gcgcuuccgu gaacucaagu      600

agccaaaccg cagcccaggu cacuaagggg gugaagcgua aagcugauac aaccacgccu      660

gccacuucug cggugaaggc auccucagag uuuagcccaa ccuucacaga gaaaaguguc      720

gcccucccac cuauuaagga aaauaugccc aaaaacguuu uacccgacuc ucagcagcaa      780

uacaaugugg uaaagacugu gaaggucacc gagcagcuga gacauugcuc cgaaauccuu      840

aaagagaugu uggcuaagaa acacuuuagc uacgccuggc cguucuauaa cccuguggau      900

guuaacgcac ugggacuaca uaauuacuau gacgugguca agaaccccau ggaucucggc      960

acaauaaaag aaaagaugga caaucaggag uacaaggaug cuuauaaauu ugccgcggac     1020

gugaggcuga uguucaugaa cuguuacaag uauaauccac cugaccacga gguaguuacc     1080

auggcccgga ugcuucagga uguguuugaa acgcauuucu cgaaaauucc caucgagcca     1140

gucgaaucua ugccccugug cuacauuaag acugacauca cagagaccac uggucgcgaa     1200

aacacaaaug aggcauccuc agaggggaac aguagcgaug acuccgaaga ugagagagug     1260

aaaagguugg cuaagcucca agaacagcug aaggccgucc accagcaguu acaagugcug     1320

ucucagguuc cuuuccggaa acucaauaag aaaaaggaga aaagcaagaa agaaaagaag     1380

aaagagaagg ugaacaauuc aaacgagaau ccacgcaaaa ugugugaaca gaugcgacuu     1440

aaggagaaaa guaagagaaa ccagccgaag aaaaggaagc aacaguuuau cggacugaaa     1500

uccgaagacg aggauaaugc uaagcccaug aacuacgacg agaaacggca guugagccua     1560

aacauuaaua agcugccugg cgauaagcuc ggccguguag uccacauaau ccaaucucgc     1620

gaaccaucac ugaguaacag caaucccgac gagauugaaa ucgauuucga gacccuuaaa     1680

gccuccacgc ugagagaauu ggagaaguau gugucugcau gccucaggaa acggccucug     1740

aagccacccg ccaaaaagau aaugaugucg aaggaggaau uacauagcca gaaaaagcag     1800

gagcuggaaa aacgacuacu cgacguuaac aaucagcuga acucccgcaa gagacaaacc     1860

aaaucagaca agacacagcc gaguaaagcu guggagaaug ucucuaggcu uagcgaaucc     1920

ucaagcagcu ccaguucuuc uuccgaguca gagaguagcu cguccgauuu gucuagcuca     1980

gacaguuccg auucugaaag cgagauguuu ccuaaguuca cugaagugaa gccaaacgac     2040

ucccccucaa aagagaaugu aaagaaaaug aagaacgaau guauuccucc cgaggggcgg     2100

accggaguga cacagaucgg uuacugcguu caggauacua ccagcgcgaa uacaacccug     2160

guccaccaaa cuacgccaag ucaugugaug ccucccaacc accaccagcu cgcauuuaau     2220

uaucaggagc uggaacaucu ucagacagug aaaaacaucu cuccacugca aauuuugccg     2280

ccuuccggcg acagcgagca gcucucgaau gggaucaccg ucaugcaccc cucaggagau     2340

ucugacacua ccaugcugga aagugagugu caggccccag uucaaaagga uauuaagauc     2400

aaaaacgcug acuccuggaa gucuuuaggc aaacccguga agccuagcgg ugugaugaaa     2460

agcuccgaug agcuguucaa ccaguuucgc aaggccgcaa uagaaaagga gguaaaagcc     2520

agaacacagg aacuaauuag gaagcaucuc gagcagaaua ccaaagaacu gaaggcuuca     2580

caagagaacc agcgugaccu ugggaaugga uugacugucg agaguuucag caacaaaauc     2640

cagaauaagu gcucuggcga ggagcagaag gaacaccaac aguccucaga ggcccaggau     2700

aaaaguaagc uguggcuccu gaaagaccgg gacuuagcac gacagaagga acaagagaga     2760

aggcgccggg aggcgauggu gggcacaauc gauaugacgc ugcagagcga cauuaugacc     2820

auguuugaaa acaauuucga uuga                                            2844


<210>  1173
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1173
augagccugc ccagcagaca gaccgccauc aucgugaacc cccccccccc cgaguacauc       60

aacaccaaga agaacggcag acugaccaac cagcugcagu accugcagaa gguggugcug      120

aaggaccugu ggaagcacag cuucagcugg cccuuccaga gacccgugga cgccgugaag      180

cugcagcugc ccgacuacua caccaucauc aagaacccca uggaccugaa caccaucaag      240

aagagacugg agaacaagua cuacgccaag gccagcgagu gcaucgagga cuucaacacc      300

auguucagca acugcuaccu guacaacaag cccggcgacg acaucgugcu gauggcccag      360

gcccuggaga agcuguucau gcagaagcug agccagaugc cccaggagga gcagguggug      420

ggcgugaagg agagaaucaa gaagggcacc cagcagaaca ucgccgugag cagcgccaag      480

gagaagagca gccccagcgc caccgagaag guguucaagc agcaggagau ccccagcgug      540

uuccccaaga ccagcaucag cccccugaac guggugcagg gcgccagcgu gaacagcagc      600

agccagaccg ccgcccaggu gaccaagggc gugaagagaa aggccgacac caccaccccc      660

gccaccagcg ccgugaaggc cagcagcgag uucagcccca ccuucaccga gaagagcgug      720

gcccugcccc ccaucaagga gaacaugccc aagaacgugc ugcccgacag ccagcagcag      780

uacaacgugg ugaagaccgu gaaggugacc gagcagcuga gacacugcag cgagauccug      840

aaggagaugc uggccaagaa gcacuucagc uacgccuggc ccuucuacaa ccccguggac      900

gugaacgccc ugggccugca caacuacuac gacgugguga agaaccccau ggaccugggc      960

accaucaagg agaagaugga caaccaggag uacaaggacg ccuacaaguu cgccgccgac     1020

gugagacuga uguucaugaa cugcuacaag uacaaccccc ccgaccacga gguggugacc     1080

auggccagaa ugcugcagga cguguucgag acccacuuca gcaagauccc caucgagccc     1140

guggagagca ugccccugug cuacaucaag accgacauca ccgagaccac cggcagagag     1200

aacaccaacg aggccagcag cgagggcaac agcagcgacg acagcgagga cgagagagug     1260

aagagacugg ccaagcugca ggagcagcug aaggccgugc accagcagcu gcaggugcug     1320

agccaggugc ccuucagaaa gcugaacaag aagaaggaga agagcaagaa ggagaagaag     1380

aaggagaagg ugaacaacag caacgagaac cccagaaaga ugugcgagca gaugagacug     1440

aaggagaaga gcaagagaaa ccagcccaag aagagaaagc agcaguucau cggccugaag     1500

agcgaggacg aggacaacgc caagcccaug aacuacgacg agaagagaca gcugagccug     1560

aacaucaaca agcugcccgg cgacaagcug ggcagagugg ugcacaucau ccagagcaga     1620

gagcccagcc ugagcaacag caaccccgac gagaucgaga ucgacuucga gacccugaag     1680

gccagcaccc ugagagagcu ggagaaguac gugagcgccu gccugagaaa gagaccccug     1740

aagccccccg ccaagaagau caugaugagc aaggaggagc ugcacagcca gaagaagcag     1800

gagcuggaga agagacugcu ggacgugaac aaccagcuga acagcagaaa gagacagacc     1860

aagagcgaca agacccagcc cagcaaggcc guggagaacg ugagcagacu gagcgagagc     1920

agcagcagca gcagcagcag cagcgagagc gagagcagca gcagcgaccu gagcagcagc     1980

gacagcagcg acagcgagag cgagauguuc cccaaguuca ccgaggugaa gcccaacgac     2040

agccccagca aggagaacgu gaagaagaug aagaacgagu gcaucccccc cgagggcaga     2100

accggcguga cccagaucgg cuacugcgug caggacacca ccagcgccaa caccacccug     2160

gugcaccaga ccacccccag ccacgugaug ccccccaacc accaccagcu ggccuucaac     2220

uaccaggagc uggagcaccu gcagaccgug aagaacauca gcccccugca gauccugccc     2280

cccagcggcg acagcgagca gcugagcaac ggcaucaccg ugaugcaccc cagcggcgac     2340

agcgacacca ccaugcugga gagcgagugc caggcccccg ugcagaagga caucaagauc     2400

aagaacgccg acagcuggaa gagccugggc aagcccguga agcccagcgg cgugaugaag     2460

agcagcgacg agcuguucaa ccaguucaga aaggccgcca ucgagaagga ggugaaggcc     2520

agaacccagg agcugaucag aaagcaccug gagcagaaca ccaaggagcu gaaggccagc     2580

caggagaacc agagagaccu gggcaacggc cugaccgugg agagcuucag caacaagauc     2640

cagaacaagu gcagcggcga ggagcagaag gagcaccagc agagcagcga ggcccaggac     2700

aagagcaagc uguggcugcu gaaggacaga gaccuggcca gacagaagga gcaggagaga     2760

agaagaagag aggccauggu gggcaccauc gacaugaccc ugcagagcga caucaugacc     2820

auguucgaga acaacuucga cuga                                            2844


<210>  1174
<211>  2844
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CT-_9/BRD6__Homo_sapiens__CCDS735.1

<400>  1174
augagccugc ccuccagaca gaccgccauc auugugaacc cuccgccccc ugaguacauc       60

aauacaaaga aaaacggccg gcucacgaau caacugcagu aucuucagaa ggucguucug      120

aaagaccucu ggaagcacuc uuucagcugg cccuuucagc gcccugugga ugcugugaaa      180

cugcaacuuc ccgacuacua uaccauuauc aagaacccua uggaucugaa uacaauuaag      240

aaaagacucg aaaacaagua cuaugccaaa gcguccgagu gcaucgaaga cuucaauacc      300

auguuuucua acuguuaccu guauaauaag ccgggggaug acaucguccu gauggcucag      360

gcccucgaga aacuguucau gcagaagcuc agccagaugc cccaagaaga acaggugguu      420

ggagugaagg agcggauuaa aaagggcaca cagcagaaca ucgccgucuc cucugcuaaa      480

gaaaagagcu ccccuagcgc caccgagaaa guguuuaagc aacaggaaau ucccucuguu      540

uucccuaaaa cauccaucag cccccugaau gugguccagg gggcuucugu gaacuccagc      600

ucucaaaccg ccgcccaggu gacgaaggga gucaagcgca aagcggauac cacaaccccg      660

gcuacauccg ccguuaaggc uagcuccgag uuuucuccua ccuucacgga gaaaagcgug      720

gcccuucccc cuauuaagga aaauaugccc aaaaacgugc ugcccgacuc ccagcagcaa      780

uacaaugucg ugaagacagu uaaggugacc gagcagcuua gacauugcag cgaaauccug      840

aaagagaugc ucgcgaagaa acacuuuucu uacgccuggc cuuucuauaa cccggucgau      900

gugaacgcuc ugggccugca uaauuacuau gacguuguga agaaccccau ggaucucggg      960

acaauuaaag aaaagaugga caaucaggag uacaaggaug ccuauaaauu ugcugccgac     1020

guccggcuga uguucaugaa cuguuacaag uauaauccuc ccgaccacga gguggucacc     1080

auggcccgca ugcuucagga uguguuugaa acccauuucu ccaaaauccc uaucgagccc     1140

guugaaagca ugccgcugug cuacauuaag acagacauca cggagaccac aggaagagaa     1200

aacaccaaug aggcuucuag cgagggcaac uccucugaug acagcgaaga ugagcgggug     1260

aaacgccucg cgaagcugca agaacagcuu aaggccgucc accagcagcu gcaagugcuc     1320

ucccagguuc cuuucagaaa acugaauaag aaaaaggaga aaagcaagaa agaaaagaag     1380

aaagagaagg ugaacaauuc uaacgagaau ccccggaaaa ugugugaaca gaugcgccug     1440

aaggagaaau ccaagagaaa ccagccuaag aaacggaagc aacaguuuau uggccucaaa     1500

agcgaagacg aggauaaugc uaagcccaug aacuacgacg agaaacgcca gcugucucuu     1560

aacaucaaua agcugccugg ggauaagcuc ggaagagucg ugcacauuau ccaaucccgg     1620

gaacccagcc uguccaacuc uaauccggac gagaucgaaa uugauuucga gacacuuaaa     1680

gccagcaccc ugagagaacu cgagaaguau guguccgccu gccugcgcaa acggccucug     1740

aagccucccg cuaaaaagau caugaugucu aaggaggaac uccauagcca gaaaaagcag     1800

gagcuggaaa agagacuucu ggacguuaac aaucagcuca acucccgcaa gcggcaaacg     1860

aaaagcgaca agacacagcc cucuaaagcc gucgagaaug uguccagacu gagcgaaucu     1920

uccagcucua gcuccucuag cuccgagagc gaguccucua gcuccgaucu gucuagcucc     1980

gacucuagcg auuccgaaag cgagauguuu ccgaaguuca ccgaagugaa gcccaacgac     2040

ucuccuucca aagagaaugu caagaaaaug aagaacgaau guauuccccc ugagggccgc     2100

accgggguga cacagaucgg auacugcguu caggauacca caagcgcgaa uacgacccuu     2160

gugcaccaaa caacccccuc ucaugucaug ccucccaacc accaccagcu cgcuuuuaau     2220

uaucaggagc uggaacaucu gcagacagug aaaaacauuu ccccgcucca aauccugccu     2280

cccagcggcg acucugagca gcuuuccaau gggaucaccg uuaugcaccc uagcggagau     2340

uccgacacga ccaugcugga aagcgagugu caggcccccg ugcaaaagga uauuaagauc     2400

aaaaacgccg acucuuggaa aagccucggc aaaccgguca agccuuccgg cgugaugaaa     2460

ucuagcgaug agcuguucaa ccaguuucgg aaggcugcca uugaaaagga gguuaaagcu     2520

agaacacagg aacugauccg caagcaucuu gagcagaaua ccaaagaacu caaggccucc     2580

caagagaacc agcgggaccu ggggaaugga cugacagugg agucuuucag caacaaaauu     2640

cagaauaagu gcuccggcga ggagcagaag gaacaccaac agucuagcga ggcgcaggau     2700

aaauccaagc ucuggcugcu uaaagacaga gaccuggccc gccagaagga acaagagcgg     2760

agacggcgcg aggcuauggu cgggaccauc gauaugacgc uccagagcga cauuaugaca     2820

auguuugaaa acaauuucga uuga                                            2844


<210>  1175
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CTAG2_Isoform_LAGE-1A__Homo_sapiens__O75638-2

<400>  1175

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Glu Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Ala Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  1176
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1176
augcaggccg aaggccgggg cacagggggu ucgacgggcg augcugaugg cccaggaggc       60

ccuggcauuc cugauggccc agggggcaau gcuggcggcc caggagaggc gggugccacg      120

ggcggcagag guccccgggg cgcaggggca gcaagggccu cggggccgag aggaggcgcc      180

ccgcgggguc cgcauggcgg ugccgcuucu gcgcaggaug gaaggugccc cugcggggcc      240

aggaggccgg acagccgccu gcuugaguug cacaucacga ugccuuucuc gucgcccaug      300

gaagcggagc ugguccgcag gauccugucc cgggaugccg caccgcuccc ccgaccaggg      360

gcgguucuga aggacuucac cguguccggc aaccuacugu uuauccgacu gacugcugca      420

gaccaccgcc aacugcagcu cuccaucagc uccugucucc agcagcuuuc ccuguugaug      480

uggaucacgc agugcuuucu gcccguguuu uuggcucagg cucccucagg gcagaggcgc      540

uaa                                                                    543


<210>  1177
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1177
augcaggccg agggccgcgg gaccggcggg agcaccggcg acgccgacgg gcccggcggc       60

ccggggaucc ccgacggccc cgggggcaac gccgggggcc ccggcgaggc cggggccacg      120

ggcgggcggg gcccgcgcgg cgccggggcc gcgcgggccu ccggcccccg cgggggcgcg      180

ccccgggggc cccacggcgg cgccgcgagc gcccaggacg ggcgcugccc gugcggcgcc      240

cggcgccccg acucccggcu gcucgagcug cacaucacca ugcccuucag cucccccaug      300

gaggccgagc uggugcgccg gauccucagc cgcgacgccg cgccgcugcc ccggcccggg      360

gccguccuga aggacuucac cguguccggc aaccuccugu ucauccgccu gaccgccgcc      420

gaccaccggc agcuccagcu gagcaucucc agcugccugc agcagcucuc ccugcugaug      480

uggaucacgc agugcuuccu ccccguguuc cuggcccagg cgccgagcgg gcagcgccgg      540

uga                                                                    543


<210>  1178
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1178
augcaggccg agggccgcgg caccggcggc uccaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggccgcg gcccccgcgg cgccggcgcc gcccgcgccu ccggcccccg cggcggcgcc      180

ccccgcggcc cccacggcgg cgccgccucc gcccaggacg gccgcugccc cugcggcgcc      240

cgccgccccg acucccgccu ccucgagcuc cacaucacca ugcccuucuc cucccccaug      300

gaggccgagc ucguccgccg cauccucucc cgcgacgccg ccccccuccc ccgccccggc      360

gccguccuca aggacuucac cgucuccggc aaccuccucu ucauccgccu caccgccgcc      420

gaccaccgcc agcuccagcu cuccaucucc uccugccucc agcagcucuc ccuccucaug      480

uggaucaccc agugcuuccu ccccgucuuc cucgcccagg cccccuccgg ccagcgccgc      540

uga                                                                    543


<210>  1179
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1179
augcaggccg agggcagagg gaccggaggu agcacaggcg acgcugaugg gcccggaggc       60

ccugguaucc cagacgggcc gggaggcaac gcaggcgggc ccggagaagc cggugcgacu      120

ggcgggaggg gaccucgggg cgcuggugcc gcacgcgccu ccgggccacg aggaggcgcu      180

ccccguggcc cucacggggg agcagccucu gcucaagaug guagaugccc auguggcgcc      240

aggcggcccg acucacgccu gcucgagcuu cauauuacga ugccuuucag uagcccaaug      300

gaagcggagc uggugagaag gauauugucc cgggaugcag ccccguuacc ccgcccuggg      360

gcuguccuga aggacuuuac cguuucugga aaucuacucu ucauccgacu gacagccgca      420

gaucacagac agcuucagcu gucgauuuca agcugcuugc agcaacucag ucugcugaug      480

uggaucacuc aguguuuucu cccaguguuc uuagcucagg cccccuccgg ccagaggcgg      540

uga                                                                    543


<210>  1180
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1180
augcaggccg agggcagagg caccggcggc agcaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggcagag gccccagagg cgccggcgcc gccagagcca gcggccccag aggcggcgcc      180

cccagaggcc cccacggcgg cgccgccagc gcccaggacg gcagaugccc cugcggcgcc      240

agaagacccg acagcagacu gcuggagcug cacaucacca ugcccuucag cagccccaug      300

gaggccgagc uggugagaag aauccugagc agagacgccg ccccccugcc cagacccggc      360

gccgugcuga aggacuucac cgugagcggc aaccugcugu ucaucagacu gaccgccgcc      420

gaccacagac agcugcagcu gagcaucagc agcugccugc agcagcugag ccugcugaug      480

uggaucaccc agugcuuccu gcccguguuc cuggcccagg cccccagcgg ccagagaaga      540

uga                                                                    543


<210>  1181
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CTAG2_Isoform_LAGE-1A__Homo_sapiens__CCDS35455.1

<400>  1181
augcaggccg agggcagagg gaccggaggc agcacagggg acgcugaugg acccggcggg       60

ccuggaaucc cggacggccc cggcgggaac gccggaggcc cuggggaagc gggagcuacg      120

ggcgggcggg gaccccgcgg cgccggcgcc gcuagagccu ccgggccucg gggaggcgcu      180

ccccgcgggc cucacggagg cgccgcgucu gcccaagaug ggagaugccc guguggagcu      240

cggcgccccg acagcagacu gcucgagcug cauauuacca ugccuuucuc cucucccaug      300

gaagccgagc uugugcggcg cauccugagc agagaugcug ccccucuccc ccggccgggc      360

gcgguccuga aggacuuuac aguuuccggc aaucuucugu ucauucgccu caccgccgcu      420

gaucacagac agcugcagcu gucuaucagc uccugccucc agcaacugag ccuucugaug      480

uggauuacac aguguuuucu cccuguguuc cuggcccagg cucccucugg gcagcggcgc      540

uga                                                                    543


<210>  1182
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CTAG2_Isoform_LAGE-1B__Homo_sapiens__O75638

<400>  1182

Met Gln Ala Glu Gly Gln Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Gln Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Met Ser Val Arg Asp Gln Asp Arg Glu Gly 
    130                 135                 140                 


Ala Gly Arg Met Arg Val Val Gly Trp Gly Leu Gly Ser Ala Ser Pro 
145                 150                 155                 160 


Glu Gly Gln Lys Ala Arg Asp Leu Arg Thr Pro Lys His Lys Val Ser 
                165                 170                 175     


Glu Gln Arg Pro Gly Thr Pro Gly Pro Pro Pro Pro Glu Gly Ala Gln 
            180                 185                 190         


Gly Asp Gly Cys Arg Gly Val Ala Phe Asn Val Met Phe Ser Ala Pro 
        195                 200                 205             


His Ile 
    210 


<210>  1183
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1183
augcaggccg aaggccaggg cacagggggu ucgacgggcg augcugaugg cccaggaggc       60

ccuggcauuc cugauggccc agggggcaau gcuggcggcc caggagaggc gggugccacg      120

ggcggcagag guccccgggg cgcaggggca gcaagggccu cggggccgag aggaggcgcc      180

ccgcgggguc cgcauggcgg ugccgcuucu gcgcaggaug gaaggugccc cugcggggcc      240

aggaggccgg acagccgccu gcuucaguug cacaucacga ugccuuucuc gucgcccaug      300

gaagcggagc ugguccgcag gauccugucc cgggaugccg caccucuccc ccgaccaggg      360

gcgguucuga aggacuucac cguguccggc aaccuacugu uuaugucagu ucgggaccag      420

gacagggaag gcgcugggcg gaugagggug guggguuggg ggcugggauc cgccuccccg      480

gaggggcaga aagcuagaga ucucagaaca cccaaacaca aggucucaga acagagaccu      540

gguacaccag gcccgccgcc acccgaggga gcccagggag augggugcag aggugucgcc      600

uuuaauguga uguucucugc cccucacauu uag                                   633


<210>  1184
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1184
augcaggccg agggccaggg gaccggcggg agcaccggcg acgccgacgg gcccggcggc       60

cccgggaucc ccgacggccc cgggggcaac gccgggggcc ccggcgaggc cggggccacg      120

ggcgggcgcg gcccgcgggg cgccggggcc gcccgcgccu ccggcccccg cgggggcgcg      180

ccccgggggc cccacggcgg cgccgcgagc gcccaggacg ggcggugccc gugcggcgcc      240

cgccggcccg acucccgccu gcuccagcug cacaucacca ugcccuucag cucccccaug      300

gaggccgagc uggugcggcg cauccucagc cgggacgccg cgccgcugcc ccgccccggg      360

gccguccuga aggacuucac cguguccggc aaccuccugu ucaugagcgu gcgggaccag      420

gaccgcgagg gggccggccg gaugcgcguc gugggcuggg ggcugggcuc cgccagcccc      480

gaggggcaga aggcccggga ccuccgcacc ccgaagcaca agguguccga gcagcggccc      540

ggcacgcccg ggcccccgcc gcccgagggc gcgcagggcg acgggugccg cggcgucgcc      600

uucaacguga uguucagcgc gccccacauc uga                                   633


<210>  1185
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1185
augcaggccg agggccaggg caccggcggc uccaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggccgcg gcccccgcgg cgccggcgcc gcccgcgccu ccggcccccg cggcggcgcc      180

ccccgcggcc cccacggcgg cgccgccucc gcccaggacg gccgcugccc cugcggcgcc      240

cgccgccccg acucccgccu ccuccagcuc cacaucacca ugcccuucuc cucccccaug      300

gaggccgagc ucguccgccg cauccucucc cgcgacgccg ccccccuccc ccgccccggc      360

gccguccuca aggacuucac cgucuccggc aaccuccucu ucauguccgu ccgcgaccag      420

gaccgcgagg gcgccggccg caugcgcguc gucggcuggg gccucggcuc cgccuccccc      480

gagggccaga aggcccgcga ccuccgcacc cccaagcaca aggucuccga gcagcgcccc      540

ggcacccccg gccccccccc ccccgagggc gcccagggcg acggcugccg cggcgucgcc      600

uucaacguca uguucuccgc cccccacauc uga                                   633


<210>  1186
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1186
augcaggccg agggccaagg gaccggaggu agcacaggcg acgcugaugg gcccggaggc       60

ccugguaucc cagacgggcc gggaggcaac gcaggcgggc ccggagaagc cggugcgacu      120

ggcgggagag gaccuagggg cgcuggugcc gcacgggccu ccgggccacg cggaggcgcu      180

ccccgaggcc cucacggggg agcagccucu gcucaggaug gucguugccc auguggcgcc      240

agaaggcccg acucacggcu gcuccagcuu cauauuacga ugccuuucag uagcccaaug      300

gaggcggaac uggugcgcag aauauugucc agggaugcag ccccguuacc ccggccuggg      360

gcuguccuga aggacuuuac cguuucugga aaucuacucu ucaugucggu gcgcgaucag      420

gaccgagagg gcgccgguag aaugagggua gugggguggg gccugggauc agcaagccca      480

gaaggccaaa aagcucggga ucuucguaca cccaagcaca aagucaguga gcagcgcccu      540

gggacuccag gacccccgcc ucccgagggu gcccagggcg acgggugcag aggaguggcg      600

uuuaacguua uguucuccgc cccacauauc uga                                   633


<210>  1187
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1187
augcaggccg agggccaggg caccggcggc agcaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggcagag gccccagagg cgccggcgcc gccagagcca gcggccccag aggcggcgcc      180

cccagaggcc cccacggcgg cgccgccagc gcccaggacg gcagaugccc cugcggcgcc      240

agaagacccg acagcagacu gcugcagcug cacaucacca ugcccuucag cagccccaug      300

gaggccgagc uggugagaag aauccugagc agagacgccg ccccccugcc cagacccggc      360

gccgugcuga aggacuucac cgugagcggc aaccugcugu ucaugagcgu gagagaccag      420

gacagagagg gcgccggcag aaugagagug gugggcuggg gccugggcag cgccagcccc      480

gagggccaga aggccagaga ccugagaacc cccaagcaca aggugagcga gcagagaccc      540

ggcacccccg gccccccccc ccccgagggc gcccagggcg acggcugcag aggcguggcc      600

uucaacguga uguucagcgc cccccacauc uga                                   633


<210>  1188
<211>  633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CTAG2_Isoform_LAGE-1B__Homo_sapiens__CAA10196

<400>  1188
augcaggccg agggccaagg gaccggaggc agcacagggg acgcugaugg acccggcggg       60

ccuggaaucc cggacggccc cggcgggaac gccggaggcc cuggggaagc gggagcuacg      120

ggcgggagag gaccccgggg cgccggcgcc gcucgcgccu ccgggccuag aggaggcgcu      180

ccccgggggc cucacggagg cgccgcgucu gcccaggaug ggcgcugccc guguggagcu      240

agacggcccg acagccgccu gcuccagcug cauauuacca ugccuuucuc cucucccaug      300

gaggccgaac uugugagacg gauccugagc cgcgaugcug ccccucuccc cagaccgggc      360

gcgguccuga aggacuuuac aguuuccggc aaucuucugu ucaugucugu gcgggaucag      420

gaccgcgagg gggccggaag aaugcgggug gucggcuggg ggcucggaag cgcuuccccu      480

gaaggccaaa aagcccgcga ucugagaacc cccaagcaca aagugagcga gcagcggccu      540

gggacacccg gacccccucc gcccgagggc gcucagggcg acgggugcag aggaguugcc      600

uuuaacguga uguucucugc cccucauauu uga                                   633


<210>  1189
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CTCFL__Homo_sapiens__Q8NI51

<400>  1189

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr 
625                 630                 635                 640 


Thr Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Thr Met Asp Lys 
            660             


<210>  1190
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CTCFL__Homo_sapiens__CCDS13459.1

<400>  1190
auggcagcca cugagaucuc uguccuuucu gagcaauuca ccaagaucaa agaacucgag       60

uugaugccgg aaaaaggccu gaaggaggag gaaaaagacg gagugugcag agagaaagac      120

caucggagcc cuagugaguu ggaggccgag cguaccucug gggccuucca ggacagcguc      180

cuggaggaag aaguggagcu ggugcuggcc cccucggagg agagcgagaa guacauccug      240

acccugcaga cggugcacuu cacuucugaa gcuguggagu ugcaggauau gagcuugcug      300

agcauacagc agcaagaagg ggugcaggug guggugcaac agccuggccc uggguugcug      360

uggcuugagg aagggccccg gcagagccug cagcagugug uggccauuag uauccagcaa      420

gagcuguacu ccccgcaaga gauggaggug uugcaguucc acgcucuaga ggagaaugug      480

augguggcca gugaagacag uaaguuagcg gugagccugg cugaaacuac uggacugauc      540

aagcucgagg aagagcagga gaagaaccag uuauuggcug aaagaacaaa ggagcagcuc      600

uuuuuugugg aaacaauguc aggagaugaa agaagugacg aaauuguucu cacaguuuca      660

aauucaaaug uggaagaaca agaggaucaa ccuacagcug gucaagcaga ugcugaaaag      720

gccaaaucua caaaaaauca aagaaagaca aagggagcaa aaggaaccuu ccacugugau      780

gucugcaugu ucaccucuuc uagaauguca aguuuuaauc gucauaugaa aacucacacc      840

agugagaagc cucaccugug ucaccucugc cugaaaaccu uccguacggu cacucugcug      900

cggaaccaug uuaacaccca cacaggaacc aggcccuaca aguguaacga cugcaacaug      960

gcauuuguca ccaguggaga acucguccga cacaggcgcu auaaacauac ucaugagaaa     1020

cccuuuaaau guuccaugug caaguaugcc aguguggagg caaguaaauu gaagcgccau     1080

guccgauccc acacugggga gcgccccuuu caguguugcc agugcagcua ugccagcaga     1140

gauaccuaca agcugaaacg ccacaugaga acgcacucag gugagaagcc uuacgaaugc     1200

cacaucugcc acacccgcuu cacccagagc gggaccauga aaauacauau ucugcagaaa     1260

cacggcgaaa auguccccaa auaccagugu ccccauugug ccaccaucau ugcacggaaa     1320

agcgaccuac gugugcauau gcgcaacuug caugcuuaca gcgcugcaga gcugaaaugc     1380

cgcuacuguu cugcugucuu ccaugaacgc uaugcccuca uucagcacca gaaaacucau     1440

aagaaugaga agagguucaa gugcaaacac ugcaguuaug ccugcaagca ggaacgucau     1500

augaccgcuc acauucguac ccacacugga gagaaaccau ucaccugccu uucuugcaau     1560

aaauguuucc gacagaagca acuucuaaac gcucacuuca ggaaauacca cgaugcaaau     1620

uucaucccga cuguuuacaa augcuccaag uguggcaaag gcuuuucccg cuggauuaac     1680

cugcacagac auucggagaa guguggauca ggggaagcaa agucggcugc uucaggaaag     1740

ggaagaagaa caagaaagag gaagcagacc auccugaagg aagccacaaa gggucagaag     1800

gaagcugcga agggauggaa ggaagccgcg aacggagacg aagcugcugc ugaggaggcu     1860

uccaccacga agggagaaca guucccagga gagauguuuc cugucgccug cagagaaacc     1920

acagccagag ucaaagagga aguggaugaa ggcgugaccu gugaaaugcu ccucaacacg     1980

auggauaagu ga                                                         1992


<210>  1191
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CTCFL__Homo_sapiens__CCDS13459.1

<400>  1191
auggccgcca ccgagaucag cgugcugucc gagcaguuca ccaagaucaa ggagcucgag       60

cugaugcccg agaagggccu gaaggaggag gagaaggacg gggucugccg cgagaaggac      120

caccggagcc cguccgagcu cgaggcggag cgcacgagcg gcgccuucca ggacuccgug      180

cuggaggagg agguggagcu gguccucgcc cccagcgagg aguccgagaa guacauccug      240

acccugcaga ccgugcacuu caccagcgag gccguggagc uccaggacau gucccugcug      300

agcauccagc agcaggaggg gguccaggug gugguccagc agcccggccc cgggcuccug      360

uggcuggagg agggcccgcg gcagucccuc cagcagugcg uggccaucag cauccagcag      420

gagcuguaca gcccccagga gauggaggug cugcaguucc acgcgcucga ggagaacguc      480

augguggccu ccgaggacuc caagcuggcc gugagccugg ccgagacgac cggccucauc      540

aagcuggagg aggagcagga gaagaaccag cugcucgcgg agcgcaccaa ggagcagcug      600

uucuucgucg agaccauguc cggggacgag cggagcgacg agaucgugcu gacggugucc      660

aacagcaacg ucgaggagca ggaggaccag cccaccgccg gccaggccga cgccgagaag      720

gccaagagca ccaagaacca gcgcaagacc aagggggcga agggcacguu ccacugcgac      780

gugugcaugu ucaccuccag ccggaugucc agcuucaacc gccacaugaa gacccacacc      840

uccgagaagc cccaccucug ccaccugugc cugaagacgu uccggaccgu gacccuccug      900

cgcaaccacg ucaacaccca cacggggacc cggccguaca agugcaacga cugcaacaug      960

gccuucguga ccagcggcga gcuggugcgc caccggcgcu acaagcacac ccacgagaag     1020

cccuucaagu gcuccaugug caaguacgcc agcgucgagg ccuccaagcu caagcggcac     1080

gugcgcagcc acacgggcga gcggcccuuc cagugcugcc agugcuccua cgccagccgc     1140

gacaccuaca agcugaagcg gcacaugcgc acccacuccg gggagaagcc cuacgagugc     1200

cacaucugcc acacccgguu cacgcagagc ggcaccauga agauccacau ccugcagaag     1260

cacggggaga acgucccgaa guaccagugc ccccacugcg cgaccaucau cgcccgcaag     1320

uccgaccucc gcgugcacau gcggaaccug cacgccuaca gcgccgccga gcugaagugc     1380

cgcuacugcu ccgcgguguu ccacgagcgg uacgcccuca uccagcacca gaagacccac     1440

aagaacgaga agcgcuucaa gugcaagcac ugcagcuacg ccugcaagca ggagcggcac     1500

augacggccc acauccgcac ccacaccggc gagaagcccu ucacgugccu guccugcaac     1560

aagugcuucc ggcagaagca gcugcucaac gcccacuucc gcaaguacca cgacgcgaac     1620

uucaucccca ccgucuacaa gugcagcaag ugcggcaagg gguucagccg guggaucaac     1680

cugcaccgcc acuccgagaa gugcggcagc ggggaggcca aguccgccgc cagcggcaag     1740

gggcggcgca cccggaagcg caagcagacc auccugaagg aggcgaccaa gggccagaag     1800

gaggccgcca agggcuggaa ggaggccgcc aacggggacg aggcggccgc cgaggaggcc     1860

uccaccacga agggcgagca guucccgggg gagauguucc ccguggccug ccgggagacc     1920

accgcgcgcg ugaaggagga ggucgacgag ggcgugaccu gcgagaugcu ccugaacacg     1980

auggacaagu ga                                                         1992


<210>  1192
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CTCFL__Homo_sapiens__CCDS13459.1

<400>  1192
auggccgcca ccgagaucuc cguccucucc gagcaguuca ccaagaucaa ggagcucgag       60

cucaugcccg agaagggccu caaggaggag gagaaggacg gcgucugccg cgagaaggac      120

caccgcuccc ccuccgagcu cgaggccgag cgcaccuccg gcgccuucca ggacuccguc      180

cucgaggagg aggucgagcu cguccucgcc cccuccgagg aguccgagaa guacauccuc      240

acccuccaga ccguccacuu caccuccgag gccgucgagc uccaggacau gucccuccuc      300

uccauccagc agcaggaggg cguccagguc gucguccagc agcccggccc cggccuccuc      360

uggcucgagg agggcccccg ccagucccuc cagcagugcg ucgccaucuc cauccagcag      420

gagcucuacu ccccccagga gauggagguc cuccaguucc acgcccucga ggagaacguc      480

auggucgccu ccgaggacuc caagcucgcc gucucccucg ccgagaccac cggccucauc      540

aagcucgagg aggagcagga gaagaaccag cuccucgccg agcgcaccaa ggagcagcuc      600

uucuucgucg agaccauguc cggcgacgag cgcuccgacg agaucguccu caccgucucc      660

aacuccaacg ucgaggagca ggaggaccag cccaccgccg gccaggccga cgccgagaag      720

gccaagucca ccaagaacca gcgcaagacc aagggcgcca agggcaccuu ccacugcgac      780

gucugcaugu ucaccuccuc ccgcaugucc uccuucaacc gccacaugaa gacccacacc      840

uccgagaagc cccaccucug ccaccucugc cucaagaccu uccgcaccgu cacccuccuc      900

cgcaaccacg ucaacaccca caccggcacc cgccccuaca agugcaacga cugcaacaug      960

gccuucguca ccuccggcga gcucguccgc caccgccgcu acaagcacac ccacgagaag     1020

cccuucaagu gcuccaugug caaguacgcc uccgucgagg ccuccaagcu caagcgccac     1080

guccgcuccc acaccggcga gcgccccuuc cagugcugcc agugcuccua cgccucccgc     1140

gacaccuaca agcucaagcg ccacaugcgc acccacuccg gcgagaagcc cuacgagugc     1200

cacaucugcc acacccgcuu cacccagucc ggcaccauga agauccacau ccuccagaag     1260

cacggcgaga acguccccaa guaccagugc ccccacugcg ccaccaucau cgcccgcaag     1320

uccgaccucc gcguccacau gcgcaaccuc cacgccuacu ccgccgccga gcucaagugc     1380

cgcuacugcu ccgccgucuu ccacgagcgc uacgcccuca uccagcacca gaagacccac     1440

aagaacgaga agcgcuucaa gugcaagcac ugcuccuacg ccugcaagca ggagcgccac     1500

augaccgccc acauccgcac ccacaccggc gagaagcccu ucaccugccu cuccugcaac     1560

aagugcuucc gccagaagca gcuccucaac gcccacuucc gcaaguacca cgacgccaac     1620

uucaucccca ccgucuacaa gugcuccaag ugcggcaagg gcuucucccg cuggaucaac     1680

cuccaccgcc acuccgagaa gugcggcucc ggcgaggcca aguccgccgc cuccggcaag     1740

ggccgccgca cccgcaagcg caagcagacc auccucaagg aggccaccaa gggccagaag     1800

gaggccgcca agggcuggaa ggaggccgcc aacggcgacg aggccgccgc cgaggaggcc     1860

uccaccacca agggcgagca guuccccggc gagauguucc ccgucgccug ccgcgagacc     1920

accgcccgcg ucaaggagga ggucgacgag ggcgucaccu gcgagaugcu ccucaacacc     1980

auggacaagu ga                                                         1992


<210>  1193
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CTCFL__Homo_sapiens__CCDS13459.1

<400>  1193
auggccgcua ccgagaucag cgugcugucc gaacaguuca caaagauuaa agagcucgaa       60

cuuaugcccg agaagggccu gaaagaagag gagaaggacg gggucugcag agaaaaagau      120

cacaggucuc cuucagaguu ggaagcagag cggacgagug gagccuuuca agacagcguu      180

uuagaggaag agguggaacu gguacuagcg ccauccgagg aaucugagaa guacauacuc      240

acucugcaga ccgugcauuu cacaucggag gcugucgaac uucaggauau gucacuguug      300

agcauccagc aacaggaggg ugugcagguu gugguccagc aaccgggccc cgggcuccug      360

uggcuggaag agggaccucg ccagagucuc cagcagugug uggccauuuc cauccaacag      420

gaauuauauu cuccacagga gauggaggua cugcaauuuc acgcacuuga agagaacguu      480

augguggcca gcgaagacuc caaguuggcu gucucacugg cagagacuac cggccuaauu      540

aaacucgaag aggagcagga aaagaaucag cugcuugccg agcgaacaaa agaacagcug      600

uucuuugugg agaccaugag uggugaugag cguagcgacg aaaucguguu gacugucucu      660

aacuccaaug uugaggaaca agaggaucag cccacagcug ggcaggccga cgcggaaaag      720

gcaaaaucaa ccaagaacca gagaaagacg aaaggagcca agggcacuuu ccauugcgau      780

guguguaugu uuaccagcag uaggaugucu uccuucaauc ggcacaugaa aacacauacu      840

agcgagaagc cucaccucug ccaccugugu uuaaaaaccu uucgcacagu aacccugcuc      900

agaaaccaug ugaauacgca cacuggcaca aggccauaca agugcaacga cuguaauaug      960

gcuuucguca ccucggggga gcuugugcgg caucgccgau auaaacacac ucacgaaaag     1020

cccuuuaagu gcucuaugug uaaauacgcc uccguugagg caucaaagcu gaaaagacau     1080

gugaggaguc acacaggaga acggccuuuc caaugcuguc agugcagcua ugcuucccgu     1140

gauaccuaca aguugaaacg ccauaugaga acgcacucug gugagaagcc auaugaaugc     1200

cauauauguc acaccagguu uacacagagc ggcacuauga agauccacau ucuacagaaa     1260

cauggggaga acgucccgaa guaccaaugc ccccacugug ccaccaucau ugcgcggaaa     1320

ucagaccugc gagugcauau gcgcaaucuc cacgccuaca gugcagcuga gcugaagugc     1380

agauauuguu ccgccguauu ccacgaaagg uacgcucuua uccagcauca gaaaacacac     1440

aagaacgaga agcgguucaa augcaagcau uguagcuaug ccugcaaaca ggaacgccac     1500

augacugcac auauaagaac ccacacagga gagaagccuu uuaccugucu gucuugcaau     1560

aaauguuuca ggcaaaagca guugcucaac gcccacuuuc guaaguacca ugaugcuaau     1620

uucauuccaa cuguuuauaa augcucaaag ugcggcaaag guuuuagucg guggaucaac     1680

cugcaccgac auagcgaaaa gugugggucc ggagaggcga aaucugcagc cucgggcaag     1740

ggcagaagga cgcgcaaacg gaagcagaca auuuuaaagg aggcuaccaa agggcaaaag     1800

gaagccgcaa aaggauggaa ggaggccgcu aacggugacg aagccgcagc ggaggaggcu     1860

agcacuacca aaggcgaaca guuccccggg gagauguuuc cuguggccug cagagaaaca     1920

accgcaaggg ucaaggagga aguggacgag ggagucacuu gugagaugcu gcuaaauaca     1980

auggauaagu ga                                                         1992


<210>  1194
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CTCFL__Homo_sapiens__CCDS13459.1

<400>  1194
auggccgcca ccgagaucag cgugcugagc gagcaguuca ccaagaucaa ggagcuggag       60

cugaugcccg agaagggccu gaaggaggag gagaaggacg gcgugugcag agagaaggac      120

cacagaagcc ccagcgagcu ggaggccgag agaaccagcg gcgccuucca ggacagcgug      180

cuggaggagg agguggagcu ggugcuggcc cccagcgagg agagcgagaa guacauccug      240

acccugcaga ccgugcacuu caccagcgag gccguggagc ugcaggacau gagccugcug      300

agcauccagc agcaggaggg cgugcaggug guggugcagc agcccggccc cggccugcug      360

uggcuggagg agggccccag acagagccug cagcagugcg uggccaucag cauccagcag      420

gagcuguaca gcccccagga gauggaggug cugcaguucc acgcccugga ggagaacgug      480

augguggcca gcgaggacag caagcuggcc gugagccugg ccgagaccac cggccugauc      540

aagcuggagg aggagcagga gaagaaccag cugcuggccg agagaaccaa ggagcagcug      600

uucuucgugg agaccaugag cggcgacgag agaagcgacg agaucgugcu gaccgugagc      660

aacagcaacg uggaggagca ggaggaccag cccaccgccg gccaggccga cgccgagaag      720

gccaagagca ccaagaacca gagaaagacc aagggcgcca agggcaccuu ccacugcgac      780

gugugcaugu ucaccagcag cagaaugagc agcuucaaca gacacaugaa gacccacacc      840

agcgagaagc cccaccugug ccaccugugc cugaagaccu ucagaaccgu gacccugcug      900

agaaaccacg ugaacaccca caccggcacc agacccuaca agugcaacga cugcaacaug      960

gccuucguga ccagcggcga gcuggugaga cacagaagau acaagcacac ccacgagaag     1020

cccuucaagu gcagcaugug caaguacgcc agcguggagg ccagcaagcu gaagagacac     1080

gugagaagcc acaccggcga gagacccuuc cagugcugcc agugcagcua cgccagcaga     1140

gacaccuaca agcugaagag acacaugaga acccacagcg gcgagaagcc cuacgagugc     1200

cacaucugcc acaccagauu cacccagagc ggcaccauga agauccacau ccugcagaag     1260

cacggcgaga acgugcccaa guaccagugc ccccacugcg ccaccaucau cgccagaaag     1320

agcgaccuga gagugcacau gagaaaccug cacgccuaca gcgccgccga gcugaagugc     1380

agauacugca gcgccguguu ccacgagaga uacgcccuga uccagcacca gaagacccac     1440

aagaacgaga agagauucaa gugcaagcac ugcagcuacg ccugcaagca ggagagacac     1500

augaccgccc acaucagaac ccacaccggc gagaagcccu ucaccugccu gagcugcaac     1560

aagugcuuca gacagaagca gcugcugaac gcccacuuca gaaaguacca cgacgccaac     1620

uucaucccca ccguguacaa gugcagcaag ugcggcaagg gcuucagcag auggaucaac     1680

cugcacagac acagcgagaa gugcggcagc ggcgaggcca agagcgccgc cagcggcaag     1740

ggcagaagaa ccagaaagag aaagcagacc auccugaagg aggccaccaa gggccagaag     1800

gaggccgcca agggcuggaa ggaggccgcc aacggcgacg aggccgccgc cgaggaggcc     1860

agcaccacca agggcgagca guuccccggc gagauguucc ccguggccug cagagagacc     1920

accgccagag ugaaggagga gguggacgag ggcgugaccu gcgagaugcu gcugaacacc     1980

auggacaagu ga                                                         1992


<210>  1195
<211>  1992
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CTCFL__Homo_sapiens__CCDS13459.1

<400>  1195
auggccgcua ccgagaucag cgugcugucc gaacaguuca caaagauuaa agagcucgaa       60

cugaugcccg agaagggccu uaaagaagag gagaaggacg gggucugcag agaaaaagau      120

caccggucuc cuagcgagcu ggaagccgag cgcacguccg gagcguuuca agacucuguu      180

cucgaggaag agguggaacu ggugcuugcu ccgagcgagg aauccgagaa guacauccug      240

acccuccaga caguccauuu caccucugag gccguggaac ugcaggauau gagccugcuc      300

uccauucagc aacaggaggg cguucaggug gucgugcagc aacccgggcc uggacugcuu      360

uggcuggaag agggccccag acagagccuc cagcagugug uugccaucuc uauucaacag      420

gaacuguauu ccccucagga gauggaggug cuucaauuuc acgcucugga agagaacguc      480

augguggcca gcgaagacuc uaagcucgcu gugucccugg ccgagacaac cgggcugauc      540

aaacucgaag aggagcagga aaagaaucag cugcuugcgg agcggacaaa agaacagcug      600

uucuuugucg agaccaugag cggagaugag cgcucugacg aaaucguucu cacggugucc      660

aacagcaaug uggaggaaca agaggaucag cccaccgccg gccaggcuga cgccgaaaag      720

gcuaaaucca caaagaacca gagaaagacc aaaggcgcca aggggacauu ccauugcgau      780

gucuguaugu uuaccucuag ccggaugucc agcuucaauc gccacaugaa aacgcauaca      840

ucugagaagc cucaccugug ccaccuuugu cugaaaaccu uuagaacagu gacccuccug      900

cggaaccaug uuaauaccca cacaggaacg cgcccguaca agugcaacga cuguaauaug      960

gcguucguga ccuccggcga gcuggucaga caucggcgcu auaaacacac acacgaaaag     1020

cccuuuaagu gcagcaugug uaaauacgcc ucuguggagg cuagcaagcu caaaagacau     1080

guucgguccc acaccgggga acgcccuuuc caaugcuguc agugcucuua ugccagcaga     1140

gauacauaca agcugaaacg gcauaugaga acccacuccg gagagaagcc cuaugaaugc     1200

cauauuuguc acacgcgcuu uacacagagc ggcaccauga agauccacau ucuucagaaa     1260

cauggggaga acgugccuaa guaccaaugc ccccacugug cuaccaucau ugcccggaaa     1320

ucugaccuga gaguccauau gcgcaaucuc cacgccuacu ccgcugcgga gcugaagugc     1380

cgguauugua gcgccguguu ccacgaaaga uacgcucuua uccagcauca gaaaacacac     1440

aagaacgaga agcgcuucaa augcaagcau uguucuuaug ccugcaaaca ggaacggcac     1500

augaccgccc auauuagaac acacacggga gagaagccgu uuaccugucu guccugcaau     1560

aaauguuucc gccaaaagca gcuccugaac gcucacuuuc ggaaguacca ugaugccaau     1620

uucaucccua cagucuauaa augcagcaag ugcggcaaag gcuuuuccag auggaucaac     1680

cugcaccgcc auucugaaaa gugugggagc ggagaggcga aauccgcugc cucuggcaag     1740

gggcggagaa cccggaaacg caagcagaca auucucaagg aggccaccaa aggacaaaag     1800

gaagcugcca aaggcuggaa ggaggcugcc aacggggacg aagcggccgc ugaggaggcc     1860

agcacgacca aaggagaaca guuccccggc gagauguuuc cuguggcuug cagagaaaca     1920

accgcccggg uuaaggagga aguggacgag ggcgucacau gugagaugcu gcuuaauacc     1980

auggauaagu ga                                                         1992


<210>  1196
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cten__Homo_sapiens__Q8IZW8

<400>  1196

Met Ser Gln Val Met Ser Ser Pro Leu Leu Ala Gly Gly His Ala Val 
1               5                   10                  15      


Ser Leu Ala Pro Cys Asp Glu Pro Arg Arg Thr Leu His Pro Ala Pro 
            20                  25                  30          


Ser Pro Ser Leu Pro Pro Gln Cys Ser Tyr Tyr Thr Thr Glu Gly Trp 
        35                  40                  45              


Gly Ala Gln Ala Leu Met Ala Pro Val Pro Cys Met Gly Pro Pro Gly 
    50                  55                  60                  


Arg Leu Gln Gln Ala Pro Gln Val Glu Ala Lys Ala Thr Cys Phe Leu 
65                  70                  75                  80  


Pro Ser Pro Gly Glu Lys Ala Leu Gly Thr Pro Glu Asp Leu Asp Ser 
                85                  90                  95      


Tyr Ile Asp Phe Ser Leu Glu Ser Leu Asn Gln Met Ile Leu Glu Leu 
            100                 105                 110         


Asp Pro Thr Phe Gln Leu Leu Pro Pro Gly Thr Gly Gly Ser Gln Ala 
        115                 120                 125             


Glu Leu Ala Gln Ser Thr Met Ser Met Arg Lys Lys Glu Glu Ser Glu 
    130                 135                 140                 


Ala Leu Asp Ile Lys Tyr Ile Glu Val Thr Ser Ala Arg Ser Arg Cys 
145                 150                 155                 160 


His Asp Gly Pro Gln His Cys Ser Ser Pro Ser Val Thr Pro Pro Phe 
                165                 170                 175     


Gly Ser Leu Arg Ser Gly Gly Leu Leu Leu Ser Arg Asp Val Pro Arg 
            180                 185                 190         


Glu Thr Arg Ser Ser Ser Glu Ser Leu Ile Phe Ser Gly Asn Gln Gly 
        195                 200                 205             


Arg Gly His Gln Arg Pro Leu Pro Pro Ser Glu Gly Leu Ser Pro Arg 
    210                 215                 220                 


Pro Pro Asn Ser Pro Ser Ile Ser Ile Pro Cys Met Gly Ser Lys Ala 
225                 230                 235                 240 


Ser Ser Pro His Gly Leu Gly Ser Pro Leu Val Ala Ser Pro Arg Leu 
                245                 250                 255     


Glu Lys Arg Leu Gly Gly Leu Ala Pro Gln Arg Gly Ser Arg Ile Ser 
            260                 265                 270         


Val Leu Ser Ala Ser Pro Val Ser Asp Val Ser Tyr Met Phe Gly Ser 
        275                 280                 285             


Ser Gln Ser Leu Leu His Ser Ser Asn Ser Ser His Gln Ser Ser Ser 
    290                 295                 300                 


Arg Ser Leu Glu Ser Pro Ala Asn Ser Ser Ser Ser Leu His Ser Leu 
305                 310                 315                 320 


Gly Ser Val Ser Leu Cys Thr Arg Pro Ser Asp Phe Gln Ala Pro Arg 
                325                 330                 335     


Asn Pro Thr Leu Thr Met Gly Gln Pro Arg Thr Pro His Ser Pro Pro 
            340                 345                 350         


Leu Ala Lys Glu His Ala Ser Ser Cys Pro Pro Ser Ile Thr Asn Ser 
        355                 360                 365             


Met Val Asp Ile Pro Ile Val Leu Ile Asn Gly Cys Pro Glu Pro Gly 
    370                 375                 380                 


Ser Ser Pro Pro Gln Arg Thr Pro Gly His Gln Asn Ser Val Gln Pro 
385                 390                 395                 400 


Gly Ala Ala Ser Pro Ser Asn Pro Cys Pro Ala Thr Arg Ser Asn Ser 
                405                 410                 415     


Gln Thr Leu Ser Asp Ala Pro Phe Thr Thr Cys Pro Glu Gly Pro Ala 
            420                 425                 430         


Arg Asp Met Gln Pro Thr Met Lys Phe Val Met Asp Thr Ser Lys Tyr 
        435                 440                 445             


Trp Phe Lys Pro Asn Ile Thr Arg Glu Gln Ala Ile Glu Leu Leu Arg 
    450                 455                 460                 


Lys Glu Glu Pro Gly Ala Phe Val Ile Arg Asp Ser Ser Ser Tyr Arg 
465                 470                 475                 480 


Gly Ser Phe Gly Leu Ala Leu Lys Val Gln Glu Val Pro Ala Ser Ala 
                485                 490                 495     


Gln Ser Arg Pro Gly Glu Asp Ser Asn Asp Leu Ile Arg His Phe Leu 
            500                 505                 510         


Ile Glu Ser Ser Ala Lys Gly Val His Leu Lys Gly Ala Asp Glu Glu 
        515                 520                 525             


Pro Tyr Phe Gly Ser Leu Ser Ala Phe Val Cys Gln His Ser Ile Met 
    530                 535                 540                 


Ala Leu Ala Leu Pro Cys Lys Leu Thr Ile Pro Gln Arg Glu Leu Gly 
545                 550                 555                 560 


Gly Ala Asp Gly Ala Ser Asp Ser Thr Asp Ser Pro Ala Ser Cys Gln 
                565                 570                 575     


Lys Lys Ser Ala Gly Cys His Thr Leu Tyr Leu Ser Ser Val Ser Val 
            580                 585                 590         


Glu Thr Leu Thr Gly Ala Leu Ala Val Gln Lys Ala Ile Ser Thr Thr 
        595                 600                 605             


Phe Glu Arg Asp Ile Leu Pro Thr Pro Thr Val Val His Phe Lys Val 
    610                 615                 620                 


Thr Glu Gln Gly Ile Thr Leu Thr Asp Val Gln Arg Lys Val Phe Phe 
625                 630                 635                 640 


Arg Arg His Tyr Pro Leu Thr Thr Leu Arg Phe Cys Gly Met Asp Pro 
                645                 650                 655     


Glu Gln Arg Lys Trp Gln Lys Tyr Cys Lys Pro Ser Trp Ile Phe Gly 
            660                 665                 670         


Phe Val Ala Lys Ser Gln Thr Glu Pro Gln Glu Asn Val Cys His Leu 
        675                 680                 685             


Phe Ala Glu Tyr Asp Met Val Gln Pro Ala Ser Gln Val Ile Gly Leu 
    690                 695                 700                 


Val Thr Ala Leu Leu Gln Asp Ala Glu Arg Met 
705                 710                 715 


<210>  1197
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cten__Homo_sapiens__CCDS11368.1

<400>  1197
augucccagg ugauguccag cccacugcug gcaggaggcc augcugucag cuuggcgccu       60

ugugaugagc ccaggaggac ccugcaccca gcacccagcc ccagccugcc accccagugu      120

ucuuacuaca ccacggaagg cuggggagcc caggcccuga uggcccccgu gcccugcaug      180

gggcccccug gccgacucca gcaagcccca cagguggagg ccaaagccac cugcuuccug      240

ccguccccug gugagaaggc cuuggggacc ccagaggacc uugacuccua cauugacuuc      300

ucacuggaga gccucaauca gaugauccug gaacuggacc ccaccuucca gcugcuuccc      360

ccagggacug ggggcuccca ggcugagcug gcccagagca ccaugucaau gagaaagaag      420

gaggaaucug aagccuugga cauaaaguac aucgagguga ccuccgccag aucaaggugc      480

cacgauggcc cccagcacug cuccagcccc ucugucaccc cgcccuucgg cucccuucgc      540

agugguggcc uccuccuuuc cagagacguc ccccgagaga cacgaagcag cagugagagc      600

cucaucuucu cugggaacca gggcaggggg caccagcgcc cucugccccc cucagagggu      660

cucuccccuc gacccccaaa uucccccagc aucucaaucc cuugcauggg gagcaaggcc      720

ucgagccccc augguuuggg cuccccgcug guggcuucuc caagacugga gaagcggcug      780

ggaggccugg ccccacagcg gggcagcagg aucucugugc ugucagccag cccagugucu      840

gaugucagcu auauguuugg aagcagccag ucccuccugc acuccagcaa cuccagccau      900

cagucaucuu ccagauccuu ggaaagucca gccaacucuu ccuccagccu ccacagccuu      960

ggcucagugu cccuguguac aagacccagu gacuuccagg cucccagaaa ccccacccua     1020

accaugggcc aacccagaac accccacucu ccaccacugg ccaaagaaca ugccagcagc     1080

ugccccccau ccaucaccaa cuccauggug gacauaccca uugugcugau caacggcugc     1140

ccagaaccag ggucuucucc accccagcgg accccaggac accagaacuc cguucaaccu     1200

ggagcugcuu cucccagcaa ccccugucca gccaccagga gcaacagcca gacccuguca     1260

gaugcccccu uuaccacaug cccagagggu cccgccaggg acaugcagcc caccaugaag     1320

uucgugaugg acacaucuaa auacugguuu aagccaaaca ucacccgaga gcaagcaauc     1380

gagcugcuga ggaaggagga gccaggggcu uuugucauaa gggacagcuc uucauaccga     1440

ggcuccuucg gccuggcccu gaaggugcag gagguucccg cgucugcuca gagucgacca     1500

ggugaggaca gcaaugaccu cauccgacac uuccucaucg agucgucugc caaaggagug     1560

caucucaaag gagcagauga ggagcccuac uuugggagcc ucucugccuu cgugugccag     1620

cauuccauca uggcccuggc ccugcccugc aaacucacca ucccacagag agaacuggga     1680

ggugcagaug gggccucgga cucuacagac agcccagccu ccugccagaa gaaaucugcg     1740

ggcugccaca cccuguaccu gagcucagug agcguggaga cccugacugg agcccuggcc     1800

gugcagaaag ccaucuccac caccuuugag agggacaucc uccccacgcc caccgugguc     1860

cacuucaaag ucacagagca gggcaucacu cugacugaug uccagaggaa gguguuuuuc     1920

cggcgccauu acccacucac cacccuccgc uucuguggua uggacccuga gcaacggaag     1980

uggcagaagu acugcaaacc cuccuggauc uuuggguuug uggccaagag ccagacagag     2040

ccucaggaga acguaugcca ccucuuugcg gaguaugaca ugguccagcc agccucgcag     2100

gucaucggcc uggugacugc ucugcugcag gacgcagaaa ggauguag                  2148


<210>  1198
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cten__Homo_sapiens__CCDS11368.1

<400>  1198
augagccagg ugauguccag cccccugcuc gccggcgggc acgccgucuc ccuggcgccg       60

ugcgacgagc cccgccggac ccugcacccc gcccccagcc cgucccuccc cccccagugc      120

agcuacuaca ccacggaggg cuggggggcc caggcccuga uggcccccgu gccgugcaug      180

ggcccccccg ggcgccugca gcaggcgccc cagguggagg ccaaggccac cugcuuccuc      240

ccgucccccg gcgagaaggc ccugggcacc cccgaggacc uggacagcua caucgacuuc      300

ucccucgaga gccugaacca gaugauccug gagcucgacc ccaccuucca gcugcugccg      360

cccgggacgg gcggguccca ggcggagcuc gcccagagca ccauguccau gcggaagaag      420

gaggagagcg aggcccugga caucaaguac aucgagguca ccuccgcccg cagccggugc      480

cacgacggcc cccagcacug cuccagcccc uccgugaccc cgcccuucgg gagccugcgc      540

agcggcggcc uccugcuguc ccgggacgug ccccgcgaga cgcggagcuc cagcgagucc      600

cucaucuuca gcgggaacca gggccgcggg caccagcggc cccugccgcc cuccgagggc      660

cugagccccc gccccccgaa cucccccagc aucuccaucc ccugcauggg cagcaaggcc      720

uccagcccgc acgggcucgg cuccccccug gucgcgagcc cccggcugga gaagcgccuc      780

gggggccugg ccccccagcg ggggucccgc aucagcgugc uguccgccag cccggugagc      840

gacgucuccu acauguucgg cagcucccag agccuccugc acuccagcaa cuccagccac      900

caguccagcu cccggagccu ggaguccccc gccaacagcu ccagcucccu ccacagccug      960

ggcagcgugu cccugugcac ccgccccagc gacuuccagg ccccccggaa cccgacccuc     1020

accauggggc agccccgcac gccccacucc cccccgcugg cgaaggagca cgccagcucc     1080

ugccccccca gcaucaccaa cuccauggug gacaucccca ucguccugau caacggcugc     1140

ccggagcccg ggagcucccc cccccagcgg accccgggcc accagaacag cgugcagccc     1200

ggggccgccu cccccagcaa ccccugcccg gccacccgcu ccaacagcca gacgcucucc     1260

gacgcgcccu ucaccaccug ccccgagggc ccggcccgcg acaugcagcc caccaugaag     1320

uucgugaugg acacgagcaa guacugguuc aagcccaaca ucacccggga gcaggccauc     1380

gagcugcugc gcaaggagga gcccggcgcc uucgucaucc gggacuccag cuccuaccgc     1440

gggagcuucg gccucgcccu gaaggugcag gaggugccgg cgagcgccca gucccggccc     1500

ggggaggaca gcaacgaccu gauccgccac uuccucaucg aguccagcgc caagggcguc     1560

caccugaagg gggccgacga ggagcccuac uucggcuccc ugagcgcguu cgugugccag     1620

cacuccauca uggcccucgc ccugcccugc aagcugacca ucccgcagcg ggagcugggc     1680

ggggccgacg gcgccagcga cuccaccgac agccccgcgu ccugccagaa gaagagcgcc     1740

gggugccaca cgcucuaccu guccagcgug uccgucgaga cccugaccgg cgcccucgcc     1800

gugcagaagg ccaucagcac cacguucgag cgcgacaucc ugcccacccc caccgugguc     1860

cacuucaagg ugaccgagca gggcaucacg cugaccgacg uccagcggaa gguguucuuc     1920

cgccggcacu acccgcucac cacccugcgc uucugcggga uggaccccga gcagcggaag     1980

uggcagaagu acugcaagcc cuccuggauc uucggcuucg uggcgaagag ccagacggag     2040

ccccaggaga acgucugcca ccuguucgcc gaguacgaca uggugcagcc ggccucccag     2100

gugaucgggc ucgucaccgc ccugcugcag gacgccgagc gcauguga                  2148


<210>  1199
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cten__Homo_sapiens__CCDS11368.1

<400>  1199
augucccagg ucauguccuc cccccuccuc gccggcggcc acgccgucuc ccucgccccc       60

ugcgacgagc cccgccgcac ccuccacccc gcccccuccc ccucccuccc cccccagugc      120

uccuacuaca ccaccgaggg cuggggcgcc caggcccuca uggcccccgu ccccugcaug      180

ggcccccccg gccgccucca gcaggccccc caggucgagg ccaaggccac cugcuuccuc      240

cccucccccg gcgagaaggc ccucggcacc cccgaggacc ucgacuccua caucgacuuc      300

ucccucgagu cccucaacca gaugauccuc gagcucgacc ccaccuucca gcuccucccc      360

cccggcaccg gcggcuccca ggccgagcuc gcccagucca ccauguccau gcgcaagaag      420

gaggaguccg aggcccucga caucaaguac aucgagguca ccuccgcccg cucccgcugc      480

cacgacggcc cccagcacug cuccuccccc uccgucaccc cccccuucgg cucccuccgc      540

uccggcggcc uccuccucuc ccgcgacguc ccccgcgaga cccgcuccuc cuccgagucc      600

cucaucuucu ccggcaacca gggccgcggc caccagcgcc cccucccccc cuccgagggc      660

cucucccccc gcccccccaa cucccccucc aucuccaucc ccugcauggg cuccaaggcc      720

uccucccccc acggccucgg cuccccccuc gucgccuccc cccgccucga gaagcgccuc      780

ggcggccucg ccccccagcg cggcucccgc aucuccgucc ucuccgccuc ccccgucucc      840

gacgucuccu acauguucgg cuccucccag ucccuccucc acuccuccaa cuccucccac      900

caguccuccu cccgcucccu cgaguccccc gccaacuccu ccuccucccu ccacucccuc      960

ggcuccgucu cccucugcac ccgccccucc gacuuccagg ccccccgcaa ccccacccuc     1020

accaugggcc agccccgcac cccccacucc cccccccucg ccaaggagca cgccuccucc     1080

ugcccccccu ccaucaccaa cuccaugguc gacaucccca ucguccucau caacggcugc     1140

cccgagcccg gcuccucccc cccccagcgc acccccggcc accagaacuc cguccagccc     1200

ggcgccgccu cccccuccaa ccccugcccc gccacccgcu ccaacuccca gacccucucc     1260

gacgcccccu ucaccaccug ccccgagggc cccgcccgcg acaugcagcc caccaugaag     1320

uucgucaugg acaccuccaa guacugguuc aagcccaaca ucacccgcga gcaggccauc     1380

gagcuccucc gcaaggagga gcccggcgcc uucgucaucc gcgacuccuc cuccuaccgc     1440

ggcuccuucg gccucgcccu caagguccag gagguccccg ccuccgccca gucccgcccc     1500

ggcgaggacu ccaacgaccu cauccgccac uuccucaucg aguccuccgc caagggcguc     1560

caccucaagg gcgccgacga ggagcccuac uucggcuccc ucuccgccuu cgucugccag     1620

cacuccauca uggcccucgc ccuccccugc aagcucacca ucccccagcg cgagcucggc     1680

ggcgccgacg gcgccuccga cuccaccgac ucccccgccu ccugccagaa gaaguccgcc     1740

ggcugccaca cccucuaccu cuccuccguc uccgucgaga cccucaccgg cgcccucgcc     1800

guccagaagg ccaucuccac caccuucgag cgcgacaucc uccccacccc caccgucguc     1860

cacuucaagg ucaccgagca gggcaucacc cucaccgacg uccagcgcaa ggucuucuuc     1920

cgccgccacu acccccucac cacccuccgc uucugcggca uggaccccga gcagcgcaag     1980

uggcagaagu acugcaagcc cuccuggauc uucggcuucg ucgccaaguc ccagaccgag     2040

ccccaggaga acgucugcca ccucuucgcc gaguacgaca ugguccagcc cgccucccag     2100

gucaucggcc ucgucaccgc ccuccuccag gacgccgagc gcauguga                  2148


<210>  1200
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cten__Homo_sapiens__CCDS11368.1

<400>  1200
augagccagg ugauguccuc uccccugcuc gccggcgggc acgcugucuc acuugcaccu       60

ugcgacgagc caagaaggac ccugcauccg gcccccaguc cuagcuugcc accccaaugu      120

uccuacuaua caacugaagg auggggugcg caggcuuuaa uggccccugu uccaugcaug      180

gggcccccug gccggcugca gcaggcacca caaguggagg ccaaggcuac guguuuccua      240

ccgucucccg gagaaaaagc acucggcacc ccugaggauc uggacucgua caucgauuuu      300

ucacuugaaa gccugaacca gaugauuuug gagcucgacc caacauucca gcugcugccc      360

ccugguacug ggggaaguca ggccgagcuc gcucaaucca ccaugucuau gcgcaagaaa      420

gaagagagcg aagccuuaga uauaaaguau aucgagguaa cauccgcgcg aucacguugc      480

cacgacggcc cacagcauug uaguagcccc ucugugaccc cgccuuuugg cucccugaga      540

ucagggggac uuuugcugag cagggauguc ccccgggaga cucgcaguuc uuccgaaagc      600

cuaauuuucu cggguaauca gggcagaggg caccagaggc cacucccucc cucugaggga      660

cuguccccac ggcccccuaa cucaccaagu aucagcauuc cgugcauggg cuccaaagca      720

ucuagccccc auggucuugg gucaccucug guggccaguc cacgcuugga aaagcgacuc      780

ggaggccugg cuccccaaag aggcuccagg aucagcguuu uaucugccuc accugugagu      840

gacgucagcu acauguuugg guccucucag ucgcugcucc acagcuccaa uucaagucac      900

cagucuagcu cccggucacu ugagagccca gcaaacucuu ccaguagccu gcauucuuug      960

ggauccgugu cacuauguac acgucccagu gauuuccaag cuccgcgcaa uccuacccug     1020

acgauggguc agccaagaac uccccacagc ccuccccucg ccaaggaaca ugcgucgucc     1080

ugcccaccuu cuauaaccaa cagcauggua gacaucccca uuguucugau caauggcugu     1140

ccagagccgg ggucaagucc uccccagagg acaccaggac accagaacuc cgugcaaccc     1200

ggcgccgcau cuccuagcaa uccaugcccc gcuacucggu ccaacucaca gacccuuagc     1260

gaugccccuu uuacaaccug uccggagggu ccagcucgag acaugcagcc cacgaugaaa     1320

uucgucaugg auacaaguaa guauugguuu aaaccuaaua uuacucgcga acaggccauc     1380

gagcuguuga gaaaggaaga accaggggca uucgugauaa gggacucuuc cagcuaccgg     1440

ggcucguuug gacucgcccu gaaagugcaa gaaguccccg cuucagcgca gucucgcccu     1500

ggcgaggaca guaacgauuu aauuagacac uuccugaucg aguccagcgc aaaggggguu     1560

caucuaaagg gagccgacga ggagccguau uuugguucuc ucagcgcuuu cgugugccag     1620

cacuccauua uggcccuggc acuucccugc aaauugacca ucccacagag ggaacugggc     1680

ggggccgaug gagcuucaga caguacugau agcccugccu cuugucaaaa gaaauccgca     1740

ggcugccaua cacucuaccu gucaagugua agcguggaga cccuuacggg ugcgcuggcu     1800

guccagaagg ccaucuccac cacauucgaa cgugacauuu ugcccacucc aaccgugguu     1860

cacuuuaaag ugacagagca ggggauaacu cucaccgaug uccagcggaa gguguucuuu     1920

cgaagacauu acccucugac aaccuuaagg uucuguggca uggaccccga gcaacgcaaa     1980

uggcagaagu auugcaagcc aucuuggauc uuuggauucg uagcaaaauc gcagacugaa     2040

ccgcaagaga auguuuguca ccuguuugcc gaauacgaua uggugcagcc ugcuagccag     2100

gucauuggcc uagugacggc ccuccugcag gacgcagagc ggauguga                  2148


<210>  1201
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cten__Homo_sapiens__CCDS11368.1

<400>  1201
augagccagg ugaugagcag cccccugcug gccggcggcc acgccgugag ccuggccccc       60

ugcgacgagc ccagaagaac ccugcacccc gcccccagcc ccagccugcc cccccagugc      120

agcuacuaca ccaccgaggg cuggggcgcc caggcccuga uggcccccgu gcccugcaug      180

ggcccccccg gcagacugca gcaggccccc cagguggagg ccaaggccac cugcuuccug      240

cccagccccg gcgagaaggc ccugggcacc cccgaggacc uggacagcua caucgacuuc      300

agccuggaga gccugaacca gaugauccug gagcuggacc ccaccuucca gcugcugccc      360

cccggcaccg gcggcagcca ggccgagcug gcccagagca ccaugagcau gagaaagaag      420

gaggagagcg aggcccugga caucaaguac aucgagguga ccagcgccag aagcagaugc      480

cacgacggcc cccagcacug cagcagcccc agcgugaccc cccccuucgg cagccugaga      540

agcggcggcc ugcugcugag cagagacgug cccagagaga ccagaagcag cagcgagagc      600

cugaucuuca gcggcaacca gggcagaggc caccagagac cccugccccc cagcgagggc      660

cugagcccca gaccccccaa cagccccagc aucagcaucc ccugcauggg cagcaaggcc      720

agcagccccc acggccuggg cagcccccug guggccagcc ccagacugga gaagagacug      780

ggcggccugg ccccccagag aggcagcaga aucagcgugc ugagcgccag ccccgugagc      840

gacgugagcu acauguucgg cagcagccag agccugcugc acagcagcaa cagcagccac      900

cagagcagca gcagaagccu ggagagcccc gccaacagca gcagcagccu gcacagccug      960

ggcagcguga gccugugcac cagacccagc gacuuccagg cccccagaaa ccccacccug     1020

accaugggcc agcccagaac cccccacagc cccccccugg ccaaggagca cgccagcagc     1080

ugccccccca gcaucaccaa cagcauggug gacaucccca ucgugcugau caacggcugc     1140

cccgagcccg gcagcagccc cccccagaga acccccggcc accagaacag cgugcagccc     1200

ggcgccgcca gccccagcaa ccccugcccc gccaccagaa gcaacagcca gacccugagc     1260

gacgcccccu ucaccaccug ccccgagggc cccgccagag acaugcagcc caccaugaag     1320

uucgugaugg acaccagcaa guacugguuc aagcccaaca ucaccagaga gcaggccauc     1380

gagcugcuga gaaaggagga gcccggcgcc uucgugauca gagacagcag cagcuacaga     1440

ggcagcuucg gccuggcccu gaaggugcag gaggugcccg ccagcgccca gagcagaccc     1500

ggcgaggaca gcaacgaccu gaucagacac uuccugaucg agagcagcgc caagggcgug     1560

caccugaagg gcgccgacga ggagcccuac uucggcagcc ugagcgccuu cgugugccag     1620

cacagcauca uggcccuggc ccugcccugc aagcugacca ucccccagag agagcugggc     1680

ggcgccgacg gcgccagcga cagcaccgac agccccgcca gcugccagaa gaagagcgcc     1740

ggcugccaca cccuguaccu gagcagcgug agcguggaga cccugaccgg cgcccuggcc     1800

gugcagaagg ccaucagcac caccuucgag agagacaucc ugcccacccc caccguggug     1860

cacuucaagg ugaccgagca gggcaucacc cugaccgacg ugcagagaaa gguguucuuc     1920

agaagacacu acccccugac cacccugaga uucugcggca uggaccccga gcagagaaag     1980

uggcagaagu acugcaagcc cagcuggauc uucggcuucg uggccaagag ccagaccgag     2040

ccccaggaga acgugugcca ccuguucgcc gaguacgaca uggugcagcc cgccagccag     2100

gugaucggcc uggugaccgc ccugcugcag gacgccgaga gaauguga                  2148


<210>  1202
<211>  2148
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cten__Homo_sapiens__CCDS11368.1

<400>  1202
augagccagg ugauguccuc uccccugcuc gccggcgggc acgcugucag ccuggccccu       60

ugcgacgagc cgagacggac ccuucauccc gcgccuuccc ccucucugcc uccccaaugu      120

agcuacuaua caacggaagg auggggcgcu caggcccuca uggccccugu uccgugcaug      180

gggcccccug gacgccugca gcaggcuccc caaguggagg ccaaggcuac cuguuuccuu      240

ccuucccccg gcgaaaaagc ccuggggaca ccggaggauc ucgacucuua caucgauuuu      300

agccuggaau cccugaacca gaugauucuc gagcuggacc cuaccuucca gcuucugccc      360

ccuggaacag gcggcagcca ggcggagcuc gcccaaucua ccauguccau gagaaagaaa      420

gaagagagcg aagcucugga uaucaaguau auugagguga caucugcccg gucccgcugc      480

cacgacgggc cccagcauug uagcucuccc uccgucaccc cuccguuugg aagccuuaga      540

uccggcgggc ugcuccuguc ucgggaugug ccccgcgaga cgagaagcuc cagcgaaucu      600

cugaucuucu ccggaaauca gggccggggg caccagcgcc cucuuccccc uagcgaggga      660

cugucuccca gaccgccuaa cagccccucc auuucuaucc cuugcauggg cagcaaggcu      720

uccagccccc auggccuugg gucuccucug guugccagcc cccggcucga aaaacgccug      780

ggaggccuug cgccgcaaag agggucccgg aucucugugc uguccgccag cccugucucc      840

gacgugucuu acauguuugg aagcucccag ucucuccugc acagcuccaa uagcucucac      900

caguccagcu cucgcucccu ggagagcccc gcuaacucua gcuccagccu ccauucucug      960

ggcuccguua gccuuuguac cagacccucc gauuuccaag ccccucggaa uccgacacug     1020

accauggggc agcccagaac accucacucu cccccucucg cuaaggaaca ugccagcucc     1080

ugucccccuu cuauuaccaa cagcauggug gacaucccca uuguccugau caauggaugc     1140

ccggagccug gcuccucucc cccucagcgc acgcccggcc accagaacag cgugcaaccg     1200

ggggccgcuu ccccuagcaa ucccugcccu gcgacacggu cuaacuccca gacccuuagc     1260

gaugcccccu uuacaaccug ucccgaggga ccugcuagag acaugcagcc gaccaugaaa     1320

uucgugaugg auacaucuaa guauugguuu aaacccaaua uuacgcgcga acaggccauc     1380

gagcugcucc ggaaggaaga accuggcgcc uucgucauua gagacuccag cucuuaccgc     1440

ggguccuuug gacuggcucu gaaaguucaa gaagugcccg ccagcgcgca gucccggccu     1500

ggcgaggaca gcaacgaucu caucagacac uuccugaucg agucuagcgc uaagggggug     1560

caucuuaagg gcgccgacga ggagcccuau uuuggauccc ugucugccuu cgucugccag     1620

cacagcauua uggcucucgc ccugccuugc aaacugacca ucccgcagcg cgaacuuggc     1680

ggggcugaug gagccuccga cucuacagau agccccgcgu ccugucaaaa gaaaucugcc     1740

ggcugccaua cccucuaccu gagcuccgug agcguugaga cacugaccgg ggcucucgcc     1800

gugcagaagg cuauuucuac gacauucgaa cgggacaucc ugccuacccc caccgucgug     1860

cacuuuaaag uuacagagca gggaauuacc cuuacagaug ugcagagaaa ggucuucuuu     1920

cgccggcauu acccucugac gacccucaga uucuguggca uggaccccga gcaacggaaa     1980

uggcagaagu auugcaagcc guccuggauc uuuggguucg uggccaaaag ccagacagaa     2040

ccucaagaga augucuguca ccuguuugcg gaauacgaua uggugcagcc cgccucucag     2100

guuaucggcc uggugaccgc ucuccuccag gacgccgagc gcauguga                  2148


<210>  1203
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cyclin_B1__Homo_sapiens__P14635

<400>  1203

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210>  1204
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cyclin_B1__Homo_sapiens__AAH06510

<400>  1204
auggcgcucc gagucaccag gaacucgaaa auuaaugcug aaaauaaggc gaagaucaac       60

auggcaggcg caaagcgcgu uccuacggcc ccugcugcaa ccuccaagcc cggacugagg      120

ccaagaacag cucuugggga cauugguaac aaagucagug aacaacugca ggccaaaaug      180

ccuaugaaga aggaagcaaa accuucagcu acuggaaaag ucauugauaa aaaacuacca      240

aaaccucuug aaaagguacc uaugcuggug ccagugccag ugucugagcc agugccagag      300

ccagaaccug agccagaacc ugagccuguu aaagaagaaa aacuuucgcc ugagccuauu      360

uugguugaua cugccucucc aagcccaaug gaaacaucug gaugugcccc ugcagaagaa      420

gaccuguguc aggcuuucuc ugauguaauu cuugcaguaa augaugugga ugcagaagau      480

ggagcugauc caaaccuuug uagugaauau gugaaagaua uuuaugcuua ucugagacaa      540

cuugaggaag agcaagcagu cagaccaaaa uaccuacugg gucgggaagu cacuggaaac      600

augagagcca uccuaauuga cuggcuagua cagguucaaa ugaaauucag guuguugcag      660

gagaccaugu acaugacugu cuccauuauu gaucgguuca ugcagaauaa uugugugccc      720

aagaagaugc ugcagcuggu uggugucacu gccauguuua uugcaagcaa auaugaagaa      780

auguacccuc cagaaauugg ugacuuugcu uuugugacug acaacacuua uacuaagcac      840

caaaucagac agauggaaau gaagauucua agagcuuuaa acuuuggucu gggucggccu      900

cuaccuuugc acuuccuucg gagagcaucu aagauuggag agguugaugu cgagcaacau      960

acuuuggcca aauaccugau ggaacuaacu auguuggacu augacauggu gcacuuuccu     1020

ccuucucaaa uugcagcagg agcuuuuugc uuagcacuga aaauucugga uaauggugaa     1080

uggacaccaa cucuacaaca uuaccuguca uauacugaag aaucucuucu uccaguuaug     1140

cagcaccugg cuaagaaugu agucauggua aaucaaggac uuacaaagca caugacuguc     1200

aagaacaagu augccacauc gaagcaugcu aagaucagca cucuaccaca gcugaauucu     1260

gcacuaguuc aagauuuagc caaggcugug gcaaaggugu aa                        1302


<210>  1205
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cyclin_B1__Homo_sapiens__AAH06510

<400>  1205
auggcccugc gcgugacccg gaacagcaag aucaacgccg agaacaaggc gaagaucaac       60

auggccggcg ccaagcgcgu ccccaccgcc ccggccgcga cguccaagcc cgggcuccgg      120

ccccgcaccg cccugggcga caucgggaac aaggugagcg agcagcugca ggccaagaug      180

cccaugaaga aggaggccaa gccguccgcg accggcaagg ugaucgacaa gaagcucccc      240

aagccccugg agaagguccc caugcuggug ccggugcccg ucagcgagcc cgugcccgag      300

ccggagcccg agcccgagcc cgagccggug aaggaggaga agcucucccc cgagcccauc      360

cuggucgaca ccgccagccc cuccccgaug gagacgagcg ggugcgcccc cgccgaggag      420

gaccugugcc aggccuucuc cgacgugauc cucgcgguga acgacgucga cgccgaggac      480

ggcgccgacc ccaaccugug cagcgaguac gugaaggaca ucuacgccua ccugcggcag      540

cucgaggagg agcaggccgu gcgccccaag uaccugcugg gccgggaggu caccgggaac      600

augcgcgcga uccucaucga cuggcugguc caggugcaga ugaaguuccg gcugcuccag      660

gagaccaugu acaugaccgu guccaucauc gaccgcuuca ugcagaacaa cugcgugccg      720

aagaagaugc ugcagcuggu gggcgucacg gccauguuca ucgccagcaa guacgaggag      780

auguacccgc ccgagaucgg ggacuucgcc uucgugaccg acaacaccua caccaagcac      840

cagauccggc agauggagau gaagauccuc cgcgcccuga acuucggccu ggggcggccc      900

cucccccugc acuuccugcg ccgggcgucc aagaucggcg agguggacgu cgagcagcac      960

acgcucgcca aguaccugau ggagcugacc augcucgacu acgacauggu gcacuucccg     1020

cccagccaga ucgccgccgg cgccuucugc cuggcgcuga agauccucga caacggggag     1080

uggaccccca cccugcagca cuaccugucc uacacggagg agagccuccu gcccgucaug     1140

cagcaccugg ccaagaacgu ggugaugguc aaccagggcc ucaccaagca caugaccgug     1200

aagaacaagu acgccaccuc caagcacgcc aagaucagca cgcugcccca gcugaacucc     1260

gcgcucgugc aggaccuggc caaggccguc gccaaggugu ga                        1302


<210>  1206
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cyclin_B1__Homo_sapiens__AAH06510

<400>  1206
auggcccucc gcgucacccg caacuccaag aucaacgccg agaacaaggc caagaucaac       60

auggccggcg ccaagcgcgu ccccaccgcc cccgccgcca ccuccaagcc cggccuccgc      120

ccccgcaccg cccucggcga caucggcaac aaggucuccg agcagcucca ggccaagaug      180

cccaugaaga aggaggccaa gcccuccgcc accggcaagg ucaucgacaa gaagcucccc      240

aagccccucg agaagguccc caugcucguc cccguccccg ucuccgagcc cguccccgag      300

cccgagcccg agcccgagcc cgagcccguc aaggaggaga agcucucccc cgagcccauc      360

cucgucgaca ccgccucccc cucccccaug gagaccuccg gcugcgcccc cgccgaggag      420

gaccucugcc aggccuucuc cgacgucauc cucgccguca acgacgucga cgccgaggac      480

ggcgccgacc ccaaccucug cuccgaguac gucaaggaca ucuacgccua ccuccgccag      540

cucgaggagg agcaggccgu ccgccccaag uaccuccucg gccgcgaggu caccggcaac      600

augcgcgcca uccucaucga cuggcucguc cagguccaga ugaaguuccg ccuccuccag      660

gagaccaugu acaugaccgu cuccaucauc gaccgcuuca ugcagaacaa cugcgucccc      720

aagaagaugc uccagcucgu cggcgucacc gccauguuca ucgccuccaa guacgaggag      780

auguaccccc ccgagaucgg cgacuucgcc uucgucaccg acaacaccua caccaagcac      840

cagauccgcc agauggagau gaagauccuc cgcgcccuca acuucggccu cggccgcccc      900

cucccccucc acuuccuccg ccgcgccucc aagaucggcg aggucgacgu cgagcagcac      960

acccucgcca aguaccucau ggagcucacc augcucgacu acgacauggu ccacuucccc     1020

cccucccaga ucgccgccgg cgccuucugc cucgcccuca agauccucga caacggcgag     1080

uggaccccca cccuccagca cuaccucucc uacaccgagg agucccuccu ccccgucaug     1140

cagcaccucg ccaagaacgu cgucaugguc aaccagggcc ucaccaagca caugaccguc     1200

aagaacaagu acgccaccuc caagcacgcc aagaucucca cccuccccca gcucaacucc     1260

gcccucgucc aggaccucgc caaggccguc gccaaggucu ga                        1302


<210>  1207
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cyclin_B1__Homo_sapiens__AAH06510

<400>  1207
auggcccuga gagugaccag gaacagcaag aucaaugcug agaacaaagc aaagauuaau       60

auggccggcg cgaaacgggu ccccacagcu ccugccgcaa cuuccaagcc agggcuccgc      120

ccgcgaacgg cccuuggaga cauagguaac aaaguuucug aacagcugca agcuaagaug      180

cccaugaaga aagaggcaaa gccuucagcc accggcaaag ugaucgauaa gaaauugcca      240

aagcccuuag aaaagguacc uaugcuggug ccaguccccg ugagugagcc uguuccagaa      300

ccggagcccg agccugaacc agagcccgug aaagaagaga agcuaagccc ugagccaauu      360

cucgucgaca cagcuucccc cucuccgaug gaaacuucgg ggugcgcccc ugcggaggaa      420

gaucuguguc aggcauucuc agacgugauc cuugccguaa augauguuga cgcugaggau      480

ggagccgacc ccaaccugug cagcgaauac gugaaagaua uuuaugcaua cuugcgucag      540

cucgaggagg aacaggcugu cagaccaaag uaucugcugg gcagggaggu gaccgguaau      600

augcgggcca uccucauaga cugguuagug caaguccaga ugaaauuucg ccugcuucag      660

gaaacaaugu acaugaccgu uaguaucauu gauagauuca ugcagaacaa uugugugccu      720

aagaaaaugu ugcaacuggu aggggugacu gcgauguuua ucgccuccaa guaugaggaa      780

auguaucccc cagagauugg agacuucgca uuugucacag auaacaccua cacgaagcac      840

cagaucaggc agauggagau gaaaauacua cgggcucuca auuucggccu gggccgcccc      900

cuuccucugc acuuuuugag acgagccucu aagauugggg aaguggacgu ugagcagcau      960

acucucgcua aauaccugau ggaauuaacc augcuggacu acgauauggu gcauuuccca     1020

ccgagccaaa ucgccgcagg agccuuuugc cucgcucuua agauucugga caacggugag     1080

uggacaccca cuuugcagca cuaucuaucc uacaccgaag agucacugcu cccugucaug     1140

cagcaucugg cgaaaaaugu gguaaugguu aaccaaggcc uuacaaagca caugaccgug     1200

aagaauaaau augcaacgag uaagcacgcc aaaaucagca cucugccaca guugaacucu     1260

gcucucgucc aggaucuggc caaggcagug gccaaagucu ga                        1302


<210>  1208
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cyclin_B1__Homo_sapiens__AAH06510

<400>  1208
auggcccuga gagugaccag aaacagcaag aucaacgccg agaacaaggc caagaucaac       60

auggccggcg ccaagagagu gcccaccgcc cccgccgcca ccagcaagcc cggccugaga      120

cccagaaccg cccugggcga caucggcaac aaggugagcg agcagcugca ggccaagaug      180

cccaugaaga aggaggccaa gcccagcgcc accggcaagg ugaucgacaa gaagcugccc      240

aagccccugg agaaggugcc caugcuggug cccgugcccg ugagcgagcc cgugcccgag      300

cccgagcccg agcccgagcc cgagcccgug aaggaggaga agcugagccc cgagcccauc      360

cugguggaca ccgccagccc cagccccaug gagaccagcg gcugcgcccc cgccgaggag      420

gaccugugcc aggccuucag cgacgugauc cuggccguga acgacgugga cgccgaggac      480

ggcgccgacc ccaaccugug cagcgaguac gugaaggaca ucuacgccua ccugagacag      540

cuggaggagg agcaggccgu gagacccaag uaccugcugg gcagagaggu gaccggcaac      600

augagagcca uccugaucga cuggcuggug caggugcaga ugaaguucag acugcugcag      660

gagaccaugu acaugaccgu gagcaucauc gacagauuca ugcagaacaa cugcgugccc      720

aagaagaugc ugcagcuggu gggcgugacc gccauguuca ucgccagcaa guacgaggag      780

auguaccccc ccgagaucgg cgacuucgcc uucgugaccg acaacaccua caccaagcac      840

cagaucagac agauggagau gaagauccug agagcccuga acuucggccu gggcagaccc      900

cugccccugc acuuccugag aagagccagc aagaucggcg agguggacgu ggagcagcac      960

acccuggcca aguaccugau ggagcugacc augcuggacu acgacauggu gcacuucccc     1020

cccagccaga ucgccgccgg cgccuucugc cuggcccuga agauccugga caacggcgag     1080

uggaccccca cccugcagca cuaccugagc uacaccgagg agagccugcu gcccgugaug     1140

cagcaccugg ccaagaacgu ggugauggug aaccagggcc ugaccaagca caugaccgug     1200

aagaacaagu acgccaccag caagcacgcc aagaucagca cccugcccca gcugaacagc     1260

gcccuggugc aggaccuggc caaggccgug gccaaggugu ga                        1302


<210>  1209
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cyclin_B1__Homo_sapiens__AAH06510

<400>  1209
auggcccuga gagugacccg gaacagcaag aucaaugcug agaacaaagc caagauuaau       60

auggcgggcg cuaaacgcgu ccccacagcc ccugccgcua cguccaagcc ggggcucaga      120

ccccggaccg cccugggaga caucggcaac aaaguuucug aacagcuuca agcuaagaug      180

ccuaugaaga aagaggccaa gcccagcgcg acagggaaag ugauugauaa gaaacugccu      240

aagccccucg aaaaggugcc uaugcugguc ccggugcccg uuuccgagcc ugugcccgaa      300

ccugagcccg agccggaacc ugagcccguc aaagaagaga aacuuucucc ugagcccauc      360

cugguggaca ccgccagccc cuccccuaug gaaacaucug gaugcgcucc ggccgaggaa      420

gaucucuguc aggcuuucag cgacguuauu cuggccguga augaugucga cgcggaggau      480

ggcgccgacc ccaaccugug cuccgaauac gugaaggaua ucuaugcuua ccuccgccag      540

cuggaggagg aacaggccgu gagaccuaag uaucuucugg ggcgggaggu caccggaaau      600

augcgcgcua uccucauuga cuggcugguu caagugcaga ugaaauuuag acuucugcag      660

gaaacaaugu acaugaccgu gagcaucauu gaucgguuca ugcagaacaa uugugucccc      720

aagaaaaugc uccaacuggu gggcguuacg gccauguuua ucgccucuaa guaugaggaa      780

auguacccuc ccgagauugg cgacuucgcu uuugugaccg auaacacaua uaccaagcac      840

cagauccgcc agauggagau gaaaauucug agagcgcuca auuucgggcu gggacggccg      900

cuuccucugc auuuucuccg cagagccucc aagaucggcg aagucgacgu ggagcagcac      960

acacuggcua aauaccuuau ggaacugacc augcucgacu acgauauggu ucauuuuccc     1020

ccuagccaaa ucgccgccgg ggcuuucugc cuggcccuga agauucucga caacggagag     1080

uggacgccca cacugcagca cuaucuuucu uacaccgaag agucccugcu cccugugaug     1140

cagcaucugg cgaaaaaugu cgugaugguc aaccaaggcc uuacaaagca caugaccgug     1200

aagaauaaau augcuaccag caagcacgcc aaaaucucua cacugcccca gcucaacucc     1260

gcccugguuc aggaucuggc uaaggccgug gcuaaagucu ga                        1302


<210>  1210
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cyclin_D1__Homo_sapiens__P24385

<400>  1210

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  1211
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cyclin_D1__Homo_sapiens__AAA58392

<400>  1211
auggaacacc agcuccugug cugcgaagug gaaaccaucc gccgcgcgua ccccgaugcc       60

aaccuccuca acgaccgggu gcugcgggcc augcugaagg cggaggagac cugcgcgccc      120

ucgguguccu acuucaaaug ugugcagaag gagguccugc cguccaugcg gaagaucguc      180

gccaccugga ugcuggaggu cugcgaggaa cagaagugcg aggaggaggu cuucccgcug      240

gccaugaacu accuggaccg cuuccugucg cuggagcccg ugaaaaagag ccgccugcag      300

cugcuggggg ccacuugcau guucguggcc ucuaagauga aggagaccau cccccugacg      360

gccgagaagc ugugcaucua caccgacaac uccauccggc ccgaggagcu gcugcaaaug      420

gagcugcucc uggugaacaa gcucaagugg aaccuggccg caaugacccc gcacgauuuc      480

auugaacacu uccucuccaa aaugccagag gcggaggaga acaaacagau cauccgcaaa      540

cacgcgcaga ccuucguugc ccucugugcc acagauguga aguucauuuc caauccgccc      600

uccauggugg cagcggggag cgugguggcc gcagugcaag gccugaaccu gaggagcccc      660

aacaacuucc uguccuacua ccgccucaca cgcuuccucu ccagagugau caagugugac      720

ccggacugcc uccgggccug ccaggagcag aucgaagccc ugcuggaguc aagccugcgc      780

caggcccagc agaacaugga ccccaaggcc gccgaggagg aggaagagga ggaggaggag      840

guggaccugg cuugcacacc caccgacgug cgggacgugg acaucuga                   888


<210>  1212
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cyclin_D1__Homo_sapiens__AAA58392

<400>  1212
auggagcacc agcugcucug cugcgaggug gagaccaucc gccgggccua ccccgacgcc       60

aaccugcuga acgaccgcgu ccuccgggcg augcugaagg ccgaggagac cugcgccccg      120

agcguguccu acuucaagug cgugcagaag gagguccugc ccagcaugcg caagaucgug      180

gccacgugga ugcucgaggu gugcgaggag cagaagugcg aggaggaggu cuucccccug      240

gccaugaacu accuggaccg guuccucucc cuggagcccg ugaagaaguc ccgccugcag      300

cuccugggcg cgaccugcau guucguggcc agcaagauga aggagaccau cccgcugacc      360

gccgagaagc ucugcaucua cacggacaac agcauccggc ccgaggagcu gcugcagaug      420

gagcuccugc uggucaacaa gcucaagugg aaccuggccg cgaugacgcc ccacgacuuc      480

aucgagcacu uccuguccaa gaugcccgag gccgaggaga acaagcagau cauccgcaag      540

cacgcccaga ccuucguggc ccucugcgcc accgacguga aguucaucag caacccgccc      600

uccauggucg cggccgggag cgugguggcc gccguccagg gccugaaccu gcgguccccc      660

aacaacuucc ucagcuacua ccgccugacc cgguuccugu cccgcgugau caagugcgac      720

cccgacugcc uccgggccug ccaggagcag aucgaggcgc ugcuggagag cucccuccgc      780

caggcccagc agaacaugga cccgaaggcc gccgaggagg aggaggagga ggaggaggag      840

guggaccugg ccugcacccc caccgacguc cgggacgugg acaucuga                   888


<210>  1213
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cyclin_D1__Homo_sapiens__AAA58392

<400>  1213
auggagcacc agcuccucug cugcgagguc gagaccaucc gccgcgccua ccccgacgcc       60

aaccuccuca acgaccgcgu ccuccgcgcc augcucaagg ccgaggagac cugcgccccc      120

uccgucuccu acuucaagug cguccagaag gagguccucc ccuccaugcg caagaucguc      180

gccaccugga ugcucgaggu cugcgaggag cagaagugcg aggaggaggu cuucccccuc      240

gccaugaacu accucgaccg cuuccucucc cucgagcccg ucaagaaguc ccgccuccag      300

cuccucggcg ccaccugcau guucgucgcc uccaagauga aggagaccau cccccucacc      360

gccgagaagc ucugcaucua caccgacaac uccauccgcc ccgaggagcu ccuccagaug      420

gagcuccucc ucgucaacaa gcucaagugg aaccucgccg ccaugacccc ccacgacuuc      480

aucgagcacu uccucuccaa gaugcccgag gccgaggaga acaagcagau cauccgcaag      540

cacgcccaga ccuucgucgc ccucugcgcc accgacguca aguucaucuc caaccccccc      600

uccauggucg ccgccggcuc cgucgucgcc gccguccagg gccucaaccu ccgcuccccc      660

aacaacuucc ucuccuacua ccgccucacc cgcuuccucu cccgcgucau caagugcgac      720

cccgacugcc uccgcgccug ccaggagcag aucgaggccc uccucgaguc cucccuccgc      780

caggcccagc agaacaugga ccccaaggcc gccgaggagg aggaggagga ggaggaggag      840

gucgaccucg ccugcacccc caccgacguc cgcgacgucg acaucuga                   888


<210>  1214
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cyclin_D1__Homo_sapiens__AAA58392

<400>  1214
auggagcacc agcugcucug cugugaagug gagaccauca gaagggccua ccccgacgcu       60

aaccuucuga augaucgggu cuugcgcgca auguuaaagg ccgaagagac augcgcgccu      120

agcguuuccu auuucaaaug ugugcaaaag gaaguacugc caucuaugcg aaaaauugug      180

gcuacuugga ugcuagaggu cugcgaggaa cagaagugug aggaagaggu guuuccgcuc      240

gccaugaacu accuggaccg uuuccuuuca cuggagcccg uuaaaaagag uagauugcag      300

cuccugggcg caacgugcau guuuguggcc agcaagauga aagaaaccau accucugaca      360

gcugagaagc ucuguaucua uacugauaau uccauuaggc cagaagaguu acugcagaug      420

gaacuuuugc uggucaacaa acuaaagugg aaucucgcag ccaugacacc ccaugacuuc      480

aucgagcacu uucugucuaa aaugccugag gcugaagaga acaagcaaau uauccggaag      540

caugcccaga ccuucguggc gcuuugcgca accgauguaa aauuuauauc gaauccaccc      600

ucaaugguug ccgcugggag cguggucgcc gcagugcagg gacugaacuu gcgcaguccu      660

aauaacuucc ucuccuacua uagacugacu agguuuuuau cucgggugau caagugugac      720

ccagauugcc ugcgcgcuug ucaggaacaa auugaggccc uccuugaaag cucccugcga      780

caggcgcagc agaauaugga cccgaaagcc gcagaggagg aagaggaaga ggaagaggag      840

gucgauuugg cuugcacacc caccgacguu agagaugugg acaucuga                   888


<210>  1215
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cyclin_D1__Homo_sapiens__AAA58392

<400>  1215
auggagcacc agcugcugug cugcgaggug gagaccauca gaagagccua ccccgacgcc       60

aaccugcuga acgacagagu gcugagagcc augcugaagg ccgaggagac cugcgccccc      120

agcgugagcu acuucaagug cgugcagaag gaggugcugc ccagcaugag aaagaucgug      180

gccaccugga ugcuggaggu gugcgaggag cagaagugcg aggaggaggu guucccccug      240

gccaugaacu accuggacag auuccugagc cuggagcccg ugaagaagag cagacugcag      300

cugcugggcg ccaccugcau guucguggcc agcaagauga aggagaccau cccccugacc      360

gccgagaagc ugugcaucua caccgacaac agcaucagac ccgaggagcu gcugcagaug      420

gagcugcugc uggugaacaa gcugaagugg aaccuggccg ccaugacccc ccacgacuuc      480

aucgagcacu uccugagcaa gaugcccgag gccgaggaga acaagcagau caucagaaag      540

cacgcccaga ccuucguggc ccugugcgcc accgacguga aguucaucag caaccccccc      600

agcauggugg ccgccggcag cgugguggcc gccgugcagg gccugaaccu gagaagcccc      660

aacaacuucc ugagcuacua cagacugacc agauuccuga gcagagugau caagugcgac      720

cccgacugcc ugagagccug ccaggagcag aucgaggccc ugcuggagag cagccugaga      780

caggcccagc agaacaugga ccccaaggcc gccgaggagg aggaggagga ggaggaggag      840

guggaccugg ccugcacccc caccgacgug agagacgugg acaucuga                   888


<210>  1216
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cyclin_D1__Homo_sapiens__AAA58392

<400>  1216
auggagcacc agcugcucug cugugaagug gagaccauca gacgggccua ccccgacgcu       60

aaccugcuua augaucgcgu ccugagagcc augcucaagg cggaagagac augcgcuccu      120

agcguuuccu auuucaaaug ugugcaaaag gaagugcugc cgucuaugcg gaaaauuguc      180

gccacgugga ugcuugaggu gugcgaggaa cagaagugug aggaagaggu uuuuccccug      240

gccaugaacu accucgaccg cuuccugagc cuggagccug ugaaaaaguc cagacuccag      300

cugcuuggcg cuaccugcau guuugucgcc ucuaagauga aagaaacaau cccccugacc      360

gcugagaagc ucuguauuua uacagauaau agcauccggc cugaggaacu gcuucagaug      420

gaacugcucc uggugaacaa acugaagugg aaucucgccg cgaugacacc ccaugacuuc      480

auugagcacu uucuguccaa aaugccugag gccgaagaga acaagcaaau cauccgcaag      540

caugcucaga ccuucguugc ccuuugcgcu accgauguga aauuuauuuc uaauccgccc      600

agcauggucg ccgcgggguc cgugguggcc gcuguccagg gacugaaccu cagaagcccu      660

aauaacuucc ugucuuacua ucggcuuacg cgcuuucugu ccagaguuau caagugugac      720

cccgauugcc uccgggccug ucaggaacaa auugaggcuc ugcuggaaag cucucuccgc      780

caggcccagc agaauaugga cccuaaagcc gcugaggagg aagaggaaga ggaagaggag      840

guggaucugg cgugcacccc cacagacgug agagaugucg acaucuga                   888


<210>  1217
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cyp-B__Homo_sapiens__P23284

<400>  1217

Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala 
            20                  25                  30          


Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe 
        35                  40                  45              


Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu 
    50                  55                  60                  


Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala 
65                  70                  75                  80  


Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val 
                85                  90                  95      


Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly 
            100                 105                 110         


Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe 
        115                 120                 125             


Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly 
    130                 135                 140                 


Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala 
145                 150                 155                 160 


Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Leu Glu Gly Met 
                165                 170                 175     


Glu Val Val Arg Lys Val Glu Ser Thr Lys Thr Asp Ser Arg Asp Lys 
            180                 185                 190         


Pro Leu Lys Asp Val Ile Ile Ala Asp Cys Gly Lys Ile Glu Val Glu 
        195                 200                 205             


Lys Pro Phe Ala Ile Ala Lys Glu 
    210                 215     


<210>  1218
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  cyp-B__Homo_sapiens__AAA36601

<400>  1218
augcugcgcc ucuccgaacg caacaugaag gugcuccuug ccgccgcccu caucgcgggg       60

uccgucuucu uccugcugcu gccgggaccu ucugcggccg augagaagaa gaaggggccc      120

aaagucaccg ucaaggugua uuuugaccua cgaauuggag augaagaugu aggccgggug      180

aucuuugguc ucuucggaaa gacuguucca aaaacagugg auaauuuugu ggccuuagcu      240

acaggagaga aaggauuugg cuacaaaaac agcaaauucc aucguguaau caaggacuuc      300

augauccagg gcggagacuu caccagggga gauggcacag gaggaaagag caucuacggu      360

gagcgcuucc ccgaugagaa cuucaaacug aagcacuacg ggccuggcug ggugagcaug      420

gccaacgcag gcaaagacac caacggcucc caguucuuca ucacgacagu caagacagcc      480

uggcuagaug gcaagcaugu gguguuuggc aaaguucuag agggcaugga gguggugcgg      540

aagguggaga gcaccaagac agacagccgg gauaaacccc ugaaggaugu gaucaucgca      600

gacugcggca agaucgaggu ggagaagccc uuugccaucg ccaaggagua g               651


<210>  1219
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       cyp-B__Homo_sapiens__AAA36601

<400>  1219
augcugcgcc ucagcgagcg gaacaugaag gugcugcugg ccgccgcgcu caucgccggc       60

uccgucuucu uccugcugcu ccccgggccg agcgccgccg acgagaagaa gaagggcccc      120

aaggugaccg ugaaggucua cuucgaccug cgcaucgggg acgaggacgu gggccgggug      180

aucuucgggc uguucggcaa gaccgucccc aagacggugg acaacuucgu ggcccucgcg      240

accggcgaga agggguucgg cuacaagaac uccaaguucc accgcgucau caaggacuuc      300

augauccagg gcggggacuu cacccgcggg gacggcaccg gcggcaagag caucuacggg      360

gagcgguucc ccgacgagaa cuucaagcug aagcacuacg ggccgggcug gguguccaug      420

gccaacgccg gcaaggacac gaacgggagc caguucuuca ucaccaccgu gaagaccgcc      480

uggcuggacg gcaagcacgu cguguucggg aaggugcucg agggcaugga ggucgugcgg      540

aagguggagu ccacgaagac cgacagccgc gacaagcccc ugaaggacgu caucaucgcg      600

gacugcggga agaucgaggu ggagaagccc uucgccaucg ccaaggagug a               651


<210>  1220
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       cyp-B__Homo_sapiens__AAA36601

<400>  1220
augcuccgcc ucuccgagcg caacaugaag guccuccucg ccgccgcccu caucgccggc       60

uccgucuucu uccuccuccu ccccggcccc uccgccgccg acgagaagaa gaagggcccc      120

aaggucaccg ucaaggucua cuucgaccuc cgcaucggcg acgaggacgu cggccgcguc      180

aucuucggcc ucuucggcaa gaccgucccc aagaccgucg acaacuucgu cgcccucgcc      240

accggcgaga agggcuucgg cuacaagaac uccaaguucc accgcgucau caaggacuuc      300

augauccagg gcggcgacuu cacccgcggc gacggcaccg gcggcaaguc caucuacggc      360

gagcgcuucc ccgacgagaa cuucaagcuc aagcacuacg gccccggcug ggucuccaug      420

gccaacgccg gcaaggacac caacggcucc caguucuuca ucaccaccgu caagaccgcc      480

uggcucgacg gcaagcacgu cgucuucggc aagguccucg agggcaugga ggucguccgc      540

aaggucgagu ccaccaagac cgacucccgc gacaagcccc ucaaggacgu caucaucgcc      600

gacugcggca agaucgaggu cgagaagccc uucgccaucg ccaaggagug a               651


<210>  1221
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       cyp-B__Homo_sapiens__AAA36601

<400>  1221
augcugagac ucagcgagag gaacaugaag gugcuucugg ccgcugcauu gaucgccggc       60

uccgucuucu uuuuacugcu acccgggccu ucugcggcug acgagaaaaa gaaaggacca      120

aagguuaccg ugaaaguaua cuucgaucuc cggauuggug acgaagaugu gggccgcguc      180

auauuugggc uguucggaaa gacagugccg aagacuguug acaauuuugu ggcccuugca      240

acgggcgaaa aagguuucgg guauaagaac ucaaaauuuc accgagucau caaggauuuc      300

augauucagg gaggcgacuu uacccguggc gaugggacag gagguaaaag uaucuacggc      360

gagagauucc ccgacgaaaa uuuuaagcug aagcauuaug ggccuggaug ggugagcaug      420

gccaacgcug gcaaagauac uaaugguucc caauucuuua uuaccacagu aaagaccgca      480

ugguuggacg ggaaacacgu uguguucgga aagguccucg agggcaugga gguggugagg      540

aaagucgaau cuacuaagac agauucgcgg gacaaaccac ugaaggaugu uaucauagcc      600

gacugcggca agaucgaggu ggaaaaaccc uucgcuauug ccaaggagug a               651


<210>  1222
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       cyp-B__Homo_sapiens__AAA36601

<400>  1222
augcugagac ugagcgagag aaacaugaag gugcugcugg ccgccgcccu gaucgccggc       60

agcguguucu uccugcugcu gcccggcccc agcgccgccg acgagaagaa gaagggcccc      120

aaggugaccg ugaaggugua cuucgaccug agaaucggcg acgaggacgu gggcagagug      180

aucuucggcc uguucggcaa gaccgugccc aagaccgugg acaacuucgu ggcccuggcc      240

accggcgaga agggcuucgg cuacaagaac agcaaguucc acagagugau caaggacuuc      300

augauccagg gcggcgacuu caccagaggc gacggcaccg gcggcaagag caucuacggc      360

gagagauucc ccgacgagaa cuucaagcug aagcacuacg gccccggcug ggugagcaug      420

gccaacgccg gcaaggacac caacggcagc caguucuuca ucaccaccgu gaagaccgcc      480

uggcuggacg gcaagcacgu gguguucggc aaggugcugg agggcaugga gguggugaga      540

aagguggaga gcaccaagac cgacagcaga gacaagcccc ugaaggacgu gaucaucgcc      600

gacugcggca agaucgaggu ggagaagccc uucgccaucg ccaaggagug a               651


<210>  1223
<211>  651
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       cyp-B__Homo_sapiens__AAA36601

<400>  1223
augcugagac ucagcgagcg gaacaugaag gugcugcuug ccgcugcccu gaucgcgggc       60

uccgucuucu uucuccugcu ucccgggccu ucugcugccg acgagaaaaa gaaaggaccg      120

aagguuaccg ugaaagugua cuucgaucug cgcauuggcg acgaagaugu cgggagagug      180

aucuuuggac ucuucggcaa gacaguuccc aagacggugg acaauuuugu cgcccuggcu      240

accggggaaa aaggauucgg cuauaagaac agcaaauuuc accgggugau uaaggauuuc      300

augauccagg gcggggacuu uacacgcgga gauggcaccg ggggaaaauc cauuuacggc      360

gagagauucc cugacgaaaa uuuuaagcug aagcauuaug ggcccggaug gguuucuaug      420

gccaacgcug gcaaagauac aaauggcagc caauucuuua ucaccacagu gaagaccgcc      480

uggcucgacg ggaaacacgu cguguucgga aaggugcugg agggcaugga ggucguucgg      540

aaaguggaau ccacgaagac cgauucucgc gacaaaccuc uuaaggaugu gaucauugcg      600

gacugcggga agaucgaggu cgaaaaaccc uucgccauug cuaaggagug a               651


<210>  1224
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DAM-10__Homo_sapiens__P43366

<400>  1224

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Lys Ala Arg Glu Glu Thr Gln Gly Leu Lys Val Ala His Ala Thr Ala 
            20                  25                  30          


Ala Glu Lys Glu Glu Cys Pro Ser Ser Ser Pro Val Leu Gly Asp Thr 
        35                  40                  45              


Pro Thr Ser Ser Pro Ala Ala Gly Ile Pro Gln Lys Pro Gln Gly Ala 
    50                  55                  60                  


Pro Pro Thr Thr Thr Ala Ala Ala Ala Val Ser Cys Thr Glu Ser Asp 
65                  70                  75                  80  


Glu Gly Ala Lys Cys Gln Gly Glu Glu Asn Ala Ser Phe Ser Gln Ala 
                85                  90                  95      


Thr Thr Ser Thr Glu Ser Ser Val Lys Asp Pro Val Ala Trp Glu Ala 
            100                 105                 110         


Gly Met Leu Met His Phe Ile Leu Arg Lys Tyr Lys Met Arg Glu Pro 
        115                 120                 125             


Ile Met Lys Ala Asp Met Leu Lys Val Val Asp Glu Lys Tyr Lys Asp 
    130                 135                 140                 


His Phe Thr Glu Ile Leu Asn Gly Ala Ser Arg Arg Leu Glu Leu Val 
145                 150                 155                 160 


Phe Gly Leu Asp Leu Lys Glu Asp Asn Pro Ser Gly His Thr Tyr Thr 
                165                 170                 175     


Leu Val Ser Lys Leu Asn Leu Thr Asn Asp Gly Asn Leu Ser Asn Asp 
            180                 185                 190         


Trp Asp Phe Pro Arg Asn Gly Leu Leu Met Pro Leu Leu Gly Val Ile 
        195                 200                 205             


Phe Leu Lys Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp Lys Phe Met 
    210                 215                 220                 


Asn Val Leu Gly Ala Tyr Asp Gly Glu Glu His Leu Ile Tyr Gly Glu 
225                 230                 235                 240 


Pro Arg Lys Phe Ile Thr Gln Asp Leu Val Gln Glu Lys Tyr Leu Lys 
                245                 250                 255     


Tyr Glu Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln Phe Leu Trp 
            260                 265                 270         


Gly Pro Arg Ala Tyr Ala Glu Thr Thr Lys Met Lys Val Leu Glu Phe 
        275                 280                 285             


Leu Ala Lys Met Asn Gly Ala Thr Pro Arg Asp Phe Pro Ser His Tyr 
    290                 295                 300                 


Glu Glu Ala Leu Arg Asp Glu Glu Glu Arg Ala Gln Val Arg Ser Ser 
305                 310                 315                 320 


Val Arg Ala Arg Arg Arg Thr Thr Ala Thr Thr Phe Arg Ala Arg Ser 
                325                 330                 335     


Arg Ala Pro Phe Ser Arg Ser Ser His Pro Met 
            340                 345         


<210>  1225
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DAM-10__Homo_sapiens__AAD10634

<400>  1225
augccucggg gucagaagag uaagcuccgu gcucgugaga aacgccgcaa ggcgcgagag       60

gagacccagg gucucaaggu ugcucacgcc acugcagcag agaaagagga gugccccucc      120

uccucuccug uuuuagggga uacucccaca agcuccccug cugcuggcau uccccagaag      180

ccucagggag cuccacccac caccacugcu gcugcagcug ugucauguac cgaaucugac      240

gaaggugcca aaugccaagg ugaggaaaau gcaaguuucu cccaggccac aacauccacu      300

gagagcucag ucaaagaucc uguagccugg gaggcaggaa ugcugaugca cuucauucua      360

cguaaguaua aaaugagaga gcccauuaug aaggcagaua ugcugaaggu uguugaugaa      420

aaguacaagg aucacuucac ugagauccuc aauggagccu cucgccgcuu ggagcucguc      480

uuuggccuug auuugaagga agacaacccu aguggccaca ccuacacccu cgucaguaag      540

cuaaaccuca ccaaugaugg aaaccugagc aaugauuggg acuuucccag gaaugggcuu      600

cugaugccuc uccugggugu gaucuucuua aagggcaacu cugccaccga ggaagagauc      660

uggaaauuca ugaauguguu gggagccuau gauggagagg agcacuuaau cuauggggaa      720

ccccguaagu ucaucaccca agaucuggug caggaaaaau aucugaagua cgagcaggug      780

cccaacagug aucccccacg cuaucaauuc cuaugggguc cgagagccua ugcugaaacc      840

accaagauga aaguccucga guuuuuggcc aagaugaaug gugccacucc ccgugacuuc      900

ccaucccauu augaagaggc uuugagagau gaggaagaga gagcccaagu ccgauccagu      960

guuagagcca ggcgucgcac uacugccacg acuuuuagag cgcguucuag agccccauuc     1020

agcagguccu cccaccccau guga                                            1044


<210>  1226
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DAM-10__Homo_sapiens__AAD10634

<400>  1226
augccccgcg gccagaaguc caagcugcgg gcccgcgaga agcggcgcaa ggcccgggag       60

gagacccagg ggcucaaggu ggcgcacgcc accgccgccg agaaggagga gugcccgagc      120

agcucccccg uccugggcga cacgcccacc agcucccccg ccgcggggau cccgcagaag      180

ccccagggcg ccccgcccac caccacggcc gccgcggccg ugagcugcac cgaguccgac      240

gagggggcca agugccaggg cgaggagaac gccagcuucu cccaggccac caccagcacg      300

gaguccagcg ugaaggaccc cgucgcgugg gaggccggca ugcugaugca cuucauccuc      360

cgcaaguaca agaugcggga gcccaucaug aaggccgaca ugcugaaggu gguggacgag      420

aaguacaagg accacuucac cgagauccug aacggggccu cccgccggcu cgagcugguc      480

uucggccugg accucaagga ggacaacccc agcgggcaca ccuacacccu gguguccaag      540

cugaaccuca cgaacgacgg caaccugagc aacgacuggg acuucccccg caacgggcug      600

cucaugccgc ugcugggcgu gaucuuccuc aagggcaacu ccgccaccga ggaggagauc      660

uggaaguuca ugaacguccu gggggcguac gacggcgagg agcaccugau cuacggggag      720

ccccggaagu ucaucaccca ggaccucgug caggagaagu accugaagua cgagcagguc      780

cccaacagcg acccgccccg cuaccaguuc cuguggggcc cccgggccua cgccgagacc      840

acgaagauga aggugcucga guuccuggcc aagaugaacg gcgccacgcc ccgcgacuuc      900

cccucccacu acgaggaggc gcugcgggac gaggaggagc gcgcccaggu gcggagcagc      960

gugcgcgccc ggcgccggac caccgccacc accuuccgcg cccgcucccg ggcgccguuc     1020

agccgcucca gccaccccau guga                                            1044


<210>  1227
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DAM-10__Homo_sapiens__AAD10634

<400>  1227
augccccgcg gccagaaguc caagcuccgc gcccgcgaga agcgccgcaa ggcccgcgag       60

gagacccagg gccucaaggu cgcccacgcc accgccgccg agaaggagga gugccccucc      120

uccucccccg uccucggcga cacccccacc uccucccccg ccgccggcau cccccagaag      180

ccccagggcg ccccccccac caccaccgcc gccgccgccg ucuccugcac cgaguccgac      240

gagggcgcca agugccaggg cgaggagaac gccuccuucu cccaggccac caccuccacc      300

gaguccuccg ucaaggaccc cgucgccugg gaggccggca ugcucaugca cuucauccuc      360

cgcaaguaca agaugcgcga gcccaucaug aaggccgaca ugcucaaggu cgucgacgag      420

aaguacaagg accacuucac cgagauccuc aacggcgccu cccgccgccu cgagcucguc      480

uucggccucg accucaagga ggacaacccc uccggccaca ccuacacccu cgucuccaag      540

cucaaccuca ccaacgacgg caaccucucc aacgacuggg acuucccccg caacggccuc      600

cucaugcccc uccucggcgu caucuuccuc aagggcaacu ccgccaccga ggaggagauc      660

uggaaguuca ugaacguccu cggcgccuac gacggcgagg agcaccucau cuacggcgag      720

ccccgcaagu ucaucaccca ggaccucguc caggagaagu accucaagua cgagcagguc      780

cccaacuccg accccccccg cuaccaguuc cucuggggcc cccgcgccua cgccgagacc      840

accaagauga agguccucga guuccucgcc aagaugaacg gcgccacccc ccgcgacuuc      900

cccucccacu acgaggaggc ccuccgcgac gaggaggagc gcgcccaggu ccgcuccucc      960

guccgcgccc gccgccgcac caccgccacc accuuccgcg cccgcucccg cgcccccuuc     1020

ucccgcuccu cccaccccau guga                                            1044


<210>  1228
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DAM-10__Homo_sapiens__AAD10634

<400>  1228
augcccagag gccaaaagag caaacugagg gcccgggaga agcgccgaaa agcucgugaa       60

gagacccagg ggcucaaggu ggcacacgcc acagcggcug aaaaagagga augcccuucc      120

ucuucaccag uccuuggaga cacuccgacg aguagccccg ccgcagguau cccucagaag      180

ccacagggcg cucccccuac cacaacugcc gcagccgcug uuuccuguac cgagucugau      240

gagggggcca agugccaggg agaagagaac gcgucguucu cacaagcaac aaccagcacu      300

gaaaguuccg ugaaagaccc aguagccugg gaggcuggca ugcugaugca uuuuauuuug      360

agaaaguaca aaaugaggga gcccauaaug aaggccgaua uguuaaaagu ggucgacgaa      420

aaguauaagg aucacuucac agagauccug aauggugcau cucggcgccu agaacucgug      480

uuugggcugg accuuaaaga ggauaacccu agcggacaua ccuacacgcu gguuuccaag      540

uugaaucuca cuaacgacgg caaucuguca aacgauuggg acuucccaag aaauggccug      600

cucaugccgu uacugggggu gauuuuucuu aaaggaaaca gugcuaccga agaggagauc      660

uggaaguuca ugaaugucuu gggugccuau gauggcgagg aacaccugau uuacggggaa      720

cccaggaaau uuaucacaca ggaccuagug caggagaagu aucucaaaua cgaacaggua      780

ccuaacagcg auccaccccg guaucaauuc cuguggggac cucgcgcgua cgccgagacu      840

accaagauga agguucuuga guuucuggca aaaaugaaug gcgcuacacc acgagacuuc      900

cccucucauu acgaagaggc cuugagagac gaagaggaaa gggcucaggu gcgguccuca      960

guccgugccc gcagaaggac cacggcaacu acauuucggg cccgaagccg cgcuccguuc     1020

aguagaucuu cccacccuau guga                                            1044


<210>  1229
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DAM-10__Homo_sapiens__AAD10634

<400>  1229
augcccagag gccagaagag caagcugaga gccagagaga agagaagaaa ggccagagag       60

gagacccagg gccugaaggu ggcccacgcc accgccgccg agaaggagga gugccccagc      120

agcagccccg ugcugggcga cacccccacc agcagccccg ccgccggcau cccccagaag      180

ccccagggcg ccccccccac caccaccgcc gccgccgccg ugagcugcac cgagagcgac      240

gagggcgcca agugccaggg cgaggagaac gccagcuuca gccaggccac caccagcacc      300

gagagcagcg ugaaggaccc cguggccugg gaggccggca ugcugaugca cuucauccug      360

agaaaguaca agaugagaga gcccaucaug aaggccgaca ugcugaaggu gguggacgag      420

aaguacaagg accacuucac cgagauccug aacggcgcca gcagaagacu ggagcuggug      480

uucggccugg accugaagga ggacaacccc agcggccaca ccuacacccu ggugagcaag      540

cugaaccuga ccaacgacgg caaccugagc aacgacuggg acuuccccag aaacggccug      600

cugaugcccc ugcugggcgu gaucuuccug aagggcaaca gcgccaccga ggaggagauc      660

uggaaguuca ugaacgugcu gggcgccuac gacggcgagg agcaccugau cuacggcgag      720

cccagaaagu ucaucaccca ggaccuggug caggagaagu accugaagua cgagcaggug      780

cccaacagcg acccccccag auaccaguuc cuguggggcc ccagagccua cgccgagacc      840

accaagauga aggugcugga guuccuggcc aagaugaacg gcgccacccc cagagacuuc      900

cccagccacu acgaggaggc ccugagagac gaggaggaga gagcccaggu gagaagcagc      960

gugagagcca gaagaagaac caccgccacc accuucagag ccagaagcag agcccccuuc     1020

agcagaagca gccaccccau guga                                            1044


<210>  1230
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DAM-10__Homo_sapiens__AAD10634

<400>  1230
augcccagag gccaaaagag caaacugcgg gcccgcgaga agagacggaa agcucgcgaa       60

gagacccagg ggcucaaggu ggcccacgcg acagcugccg aaaaagagga augcccuucc      120

ucuagcccgg uccugggaga cacgcccacc uccucuccug ccgcuggcau cccccagaag      180

ccucaggggg cucccccuac aaccacagcc gccgcggccg uuagcuguac cgaguccgau      240

gagggagcua agugccaggg cgaagagaac gccucuuuca gccaagcuac aaccuccacg      300

gaaagcucug ugaaagaccc gguggccugg gaggcgggga ugcuuaugca uuuuauucug      360

agaaaguaca aaaugcggga gcccaucaug aaggccgaua ugcucaaagu cguggacgaa      420

aaguauaagg aucacuucac cgagauucug aauggagcuu cccgcagacu ugaacugguu      480

uuuggccucg accugaaaga ggauaacccu agcggccaua cauacacccu ggugucuaag      540

cucaaucuga caaacgacgg gaaucuuucc aacgauuggg acuucccccg gaauggacug      600

cucaugccuc ugcuuggcgu caucuuucug aaagggaaca gcgccaccga agaggagauu      660

uggaaguuca ugaaugugcu cggagcuuau gauggcgagg aacaccugau cuacggggaa      720

ccccgcaaau uuaucacgca ggaccugguu caggagaagu aucucaaaua cgaacaggug      780

ccgaacucug auccucccag auaucaauuc cuguggggac cucgggccua cgccgagaca      840

accaagauga agguccuuga guuucuggcu aaaaugaaug gcgcgacacc ccgcgacuuc      900

cccucccauu acgaagaggc ccucagagac gaagaggaac gggcucaggu gcgcagcucc      960

gugagagccc ggagacgcac caccgccaca acguuucggg cuagaucucg cgccccuuuc     1020

agccggucca gccacccgau guga                                            1044


<210>  1231
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DEP1A__Homo_sapiens__Q5TB30

<400>  1231

Met Glu Ser Gln Gly Val Pro Pro Gly Pro Tyr Arg Ala Thr Lys Leu 
1               5                   10                  15      


Trp Asn Glu Val Thr Thr Ser Phe Arg Ala Gly Met Pro Leu Arg Lys 
            20                  25                  30          


His Arg Gln His Phe Lys Lys Tyr Gly Asn Cys Phe Thr Ala Gly Glu 
        35                  40                  45              


Ala Val Asp Trp Leu Tyr Asp Leu Leu Arg Asn Asn Ser Asn Phe Gly 
    50                  55                  60                  


Pro Glu Val Thr Arg Gln Gln Thr Ile Gln Leu Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Lys Asn His Val Ile Glu Asp Ile Lys Gly Arg Trp Gly Ser Glu Asn 
                85                  90                  95      


Val Asp Asp Asn Asn Gln Leu Phe Arg Phe Pro Ala Thr Ser Pro Leu 
            100                 105                 110         


Lys Thr Leu Pro Arg Arg Tyr Pro Glu Leu Arg Lys Asn Asn Ile Glu 
        115                 120                 125             


Asn Phe Ser Lys Asp Lys Asp Ser Ile Phe Lys Leu Arg Asn Leu Ser 
    130                 135                 140                 


Arg Arg Thr Pro Lys Arg His Gly Leu His Leu Ser Gln Glu Asn Gly 
145                 150                 155                 160 


Glu Lys Ile Lys His Glu Ile Ile Asn Glu Asp Gln Glu Asn Ala Ile 
                165                 170                 175     


Asp Asn Arg Glu Leu Ser Gln Glu Asp Val Glu Glu Val Trp Arg Tyr 
            180                 185                 190         


Val Ile Leu Ile Tyr Leu Gln Thr Ile Leu Gly Val Pro Ser Leu Glu 
        195                 200                 205             


Glu Val Ile Asn Pro Lys Gln Val Ile Pro Gln Tyr Ile Met Tyr Asn 
    210                 215                 220                 


Met Ala Asn Thr Ser Lys Arg Gly Val Val Ile Leu Gln Asn Lys Ser 
225                 230                 235                 240 


Asp Asp Leu Pro His Trp Val Leu Ser Ala Met Lys Cys Leu Ala Asn 
                245                 250                 255     


Trp Pro Arg Ser Asn Asp Met Asn Asn Pro Thr Tyr Val Gly Phe Glu 
            260                 265                 270         


Arg Asp Val Phe Arg Thr Ile Ala Asp Tyr Phe Leu Asp Leu Pro Glu 
        275                 280                 285             


Pro Leu Leu Thr Phe Glu Tyr Tyr Glu Leu Phe Val Asn Ile Leu Val 
    290                 295                 300                 


Val Cys Gly Tyr Ile Thr Val Ser Asp Arg Ser Ser Gly Ile His Lys 
305                 310                 315                 320 


Ile Gln Asp Asp Pro Gln Ser Ser Lys Phe Leu His Leu Asn Asn Leu 
                325                 330                 335     


Asn Ser Phe Lys Ser Thr Glu Cys Leu Leu Leu Ser Leu Leu His Arg 
            340                 345                 350         


Glu Lys Asn Lys Glu Glu Ser Asp Ser Thr Glu Arg Leu Gln Ile Ser 
        355                 360                 365             


Asn Pro Gly Phe Gln Glu Arg Cys Ala Lys Lys Met Gln Leu Val Asn 
    370                 375                 380                 


Leu Arg Asn Arg Arg Val Ser Ala Asn Asp Ile Met Gly Gly Ser Cys 
385                 390                 395                 400 


His Asn Leu Ile Gly Leu Ser Asn Met His Asp Leu Ser Ser Asn Ser 
                405                 410                 415     


Lys Pro Arg Cys Cys Ser Leu Glu Gly Ile Val Asp Val Pro Gly Asn 
            420                 425                 430         


Ser Ser Lys Glu Ala Ser Ser Val Phe His Gln Ser Phe Pro Asn Ile 
        435                 440                 445             


Glu Gly Gln Asn Asn Lys Leu Phe Leu Glu Ser Lys Pro Lys Gln Glu 
    450                 455                 460                 


Phe Leu Leu Asn Leu His Ser Glu Glu Asn Ile Gln Lys Pro Phe Ser 
465                 470                 475                 480 


Ala Gly Phe Lys Arg Thr Ser Thr Leu Thr Val Gln Asp Gln Glu Glu 
                485                 490                 495     


Leu Cys Asn Gly Lys Cys Lys Ser Lys Gln Leu Cys Arg Ser Gln Ser 
            500                 505                 510         


Leu Leu Leu Arg Ser Ser Thr Arg Arg Asn Ser Tyr Ile Asn Thr Pro 
        515                 520                 525             


Val Ala Glu Ile Ile Met Lys Pro Asn Val Gly Gln Gly Ser Thr Ser 
    530                 535                 540                 


Val Gln Thr Ala Met Glu Ser Glu Leu Gly Glu Ser Ser Ala Thr Ile 
545                 550                 555                 560 


Asn Lys Arg Leu Cys Lys Ser Thr Ile Glu Leu Ser Glu Asn Ser Leu 
                565                 570                 575     


Leu Pro Ala Ser Ser Met Leu Thr Gly Thr Gln Ser Leu Leu Gln Pro 
            580                 585                 590         


His Leu Glu Arg Val Ala Ile Asp Ala Leu Gln Leu Cys Cys Leu Leu 
        595                 600                 605             


Leu Pro Pro Pro Asn Arg Arg Lys Leu Gln Leu Leu Met Arg Met Ile 
    610                 615                 620                 


Ser Arg Met Ser Gln Asn Val Asp Met Pro Lys Leu His Asp Ala Met 
625                 630                 635                 640 


Gly Thr Arg Ser Leu Met Ile His Thr Phe Ser Arg Cys Val Leu Cys 
                645                 650                 655     


Cys Ala Glu Glu Val Asp Leu Asp Glu Leu Leu Ala Gly Arg Leu Val 
            660                 665                 670         


Ser Phe Leu Met Asp His His Gln Glu Ile Leu Gln Val Pro Ser Tyr 
        675                 680                 685             


Leu Gln Thr Ala Val Glu Lys His Leu Asp Tyr Leu Lys Lys Gly His 
    690                 695                 700                 


Ile Glu Asn Pro Gly Asp Gly Leu Phe Ala Pro Leu Pro Thr Tyr Ser 
705                 710                 715                 720 


Tyr Cys Lys Gln Ile Ser Ala Gln Glu Phe Asp Glu Gln Lys Val Ser 
                725                 730                 735     


Thr Ser Gln Ala Ala Ile Ala Glu Leu Leu Glu Asn Ile Ile Lys Asn 
            740                 745                 750         


Arg Ser Leu Pro Leu Lys Glu Lys Arg Lys Lys Leu Lys Gln Phe Gln 
        755                 760                 765             


Lys Glu Tyr Pro Leu Ile Tyr Gln Lys Arg Phe Pro Thr Thr Glu Ser 
    770                 775                 780                 


Glu Ala Ala Leu Phe Gly Asp Lys Pro Thr Ile Lys Gln Pro Met Leu 
785                 790                 795                 800 


Ile Leu Arg Lys Pro Lys Phe Arg Ser Leu Arg 
                805                 810     


<210>  1232
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DEP1A__Homo_sapiens__BAF91373

<400>  1232
auggagaguc agggugugcc ucccgggccu uaucgggcca ccaagcugug gaaugaaguu       60

accacaucuu uucgagcagg aaugccucua agaaaacaca gacaacacuu uaaaaaauau      120

ggcaauuguu ucacagcagg agaagcagug gauuggcuuu augaccuauu aagaaauaau      180

agcaauuuug guccugaagu uacaaggcaa cagacuaucc aacuguugag gaaauuucuu      240

aagaaucaug uaauugaaga uaucaaaggg agguggggau cagaaaaugu ugaugauaac      300

aaccagcucu ucagauuucc ugcaacuucg ccacuuaaaa cucuaccacg aagguaucca      360

gaauugagaa aaaacaacau agagaacuuu uccaaagaua aagauagcau uuuuaaauua      420

cgaaacuuau cucguagaac uccuaaaagg cauggauuac auuuaucuca ggaaaauggc      480

gagaaaauaa agcaugaaau aaucaaugaa gaucaagaaa augcaauuga uaauagagaa      540

cuaagccagg aagauguuga agaaguuugg agauauguua uucugaucua ccugcaaacc      600

auuuuaggug ugccaucccu agaagaaguc auaaauccaa aacaaguaau uccccaauau      660

auaauguaca acauggccaa uacaaguaaa cguggaguag uuauacuaca aaacaaauca      720

gaugaccucc cucacugggu auuaucugcc augaagugcc uagcaaauug gccaagaagc      780

aaugauauga auaauccaac uuauguugga uuugaacgag auguauucag aacaaucgca      840

gauuauuuuc uagaucuccc ugaaccucua cuuacuuuug aauauuacga auuauuugua      900

aacauuuugg uuguuugugg cuacaucaca guuucagaua gauccagugg gauacauaaa      960

auucaagaug auccacaguc uucaaaauuc cuucacuuaa acaauuugaa uuccuucaaa     1020

ucaacugagu gccuucuucu cagucugcuu cauagagaaa aaaacaaaga agaaucagau     1080

ucuacugaga gacuacagau aagcaaucca ggauuucaag aaagaugugc uaagaaaaug     1140

cagcuaguua auuuaagaaa cagaagagug agugcuaaug acauaauggg aggaaguugu     1200

cauaauuuaa uaggguuaag uaauaugcau gaucuauccu cuaacagcaa accaaggugc     1260

uguucuuugg aaggaauugu agaugugcca gggaauucaa guaaagaggc auccaguguc     1320

uuucaucaau cuuuuccgaa cauagaagga caaaauaaua aacuguuuuu agagucuaag     1380

cccaaacagg aauuccuguu gaaucuucau ucagaggaaa auauucaaaa gccauucagu     1440

gcugguuuua agagaaccuc uacuuugacu guucaagacc aagaggaguu guguaauggg     1500

aaaugcaagu caaaacagcu uuguaggucu cagaguuugc uuuuaagaag uaguacaaga     1560

aggaauaguu auaucaauac accaguggcu gaaauuauca ugaaaccaaa uguuggacaa     1620

ggcagcacaa gugugcaaac agcuauggaa agugaacucg gagagucuag ugccacaauc     1680

aauaaaagac ucugcaaaag uacaauagaa cuuucagaaa auucuuuacu uccagcuucu     1740

ucuauguuga cuggcacaca aagcuugcug caaccucauu uagagagggu ugccaucgau     1800

gcucuacagu uauguuguuu guuacuuccc ccaccaaauc guagaaagcu ucaacuuuua     1860

augcguauga uuucccgaau gagucaaaau guugauaugc ccaaacuuca ugaugcaaug     1920

gguacgaggu cacugaugau acauaccuuu ucucgaugug uguuaugcug ugcugaagaa     1980

guggaucuug augagcuucu ugcuggaaga uuaguuucuu ucuuaaugga ucaucaucag     2040

gaaauucuuc aaguacccuc uuacuuacag acugcagugg aaaaacaucu ugacuacuua     2100

aaaaagggac auauugaaaa uccuggagau ggacuauuug cuccuuugcc aacuuacuca     2160

uacuguaagc agauuagugc ucaggaguuu gaugagcaaa aaguuucuac cucucaagcu     2220

gcaauugcag aacuuuuaga aaauauuauu aaaaacagga guuuaccucu aaaggagaaa     2280

agaaaaaaac uaaaacaguu ucagaaggaa uauccuuuga uauaucagaa aagauuucca     2340

accacggaga gugaagcagc acuuuuuggu gacaaaccua caaucaagca accaaugcug     2400

auuuuaagaa aaccaaaguu ccguagucua agauaa                               2436


<210>  1233
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DEP1A__Homo_sapiens__BAF91373

<400>  1233
auggagagcc agggcgugcc cccggggccc uaccgcgcca ccaagcugug gaacgagguc       60

accacguccu uccgggccgg caugccccuc cgcaagcacc ggcagcacuu caagaaguac      120

gggaacugcu ucaccgcggg cgaggccgug gacuggcugu acgaccugcu ccgcaacaac      180

agcaacuucg ggcccgaggu gacccggcag cagaccaucc agcugcugcg caaguuccuc      240

aagaaccacg ucaucgagga caucaagggc cgguggggcu ccgagaacgu ggacgacaac      300

aaccagcugu uccgcuuccc ggccacgagc ccccugaaga cccucccccg gcgcuacccc      360

gagcugcgga agaacaacau cgagaacuuc uccaaggaca aggacagcau cuucaagcug      420

cgcaaccucu cccggcgcac cccgaagcgg cacgggcugc accugagcca ggagaacggc      480

gagaagauca agcacgagau caucaacgag gaccaggaga acgccaucga caaccgcgag      540

cucucccagg aggacgugga ggaggucugg cgguacguga uccugaucua ccugcagacc      600

auccucgggg ugcccagccu ggaggagguc aucaacccca agcaggucau cccccaguac      660

aucauguaca acauggccaa cacguccaag cgcggcgugg ugauccugca gaacaagagc      720

gacgaccucc cgcacugggu gcuguccgcg augaagugcc uggccaacug gccccggagc      780

aacgacauga acaaccccac cuacgugggg uucgagcgcg acgucuuccg gaccaucgcc      840

gacuacuucc ucgaccugcc cgagccgcug cucaccuucg aguacuacga gcuguucgug      900

aacauccugg uggucugcgg cuacaucacg guguccgacc gcagcuccgg cauccacaag      960

auccaggacg acccccagag cuccaaguuc cuccaccuga acaaccugaa cagcuucaag     1020

agcaccgagu gccuccugcu gucccuccug caccgcgaga agaacaagga ggagagcgac     1080

uccaccgagc ggcugcagau cagcaacccc ggguuccagg agcgcugcgc caagaagaug     1140

cagcucguga accugcggaa ccgccggguc uccgcgaacg acaucauggg cgggagcugc     1200

cacaaccuga ucggccucuc caacaugcac gaccugagcu ccaacagcaa gccccgcugc     1260

ugcucccugg agggcaucgu ggacgugccg gggaacagcu ccaaggaggc cagcuccguc     1320

uuccaccaga gcuuccccaa caucgagggc cagaacaaca agcuguuccu ggaguccaag     1380

cccaagcagg aguuccugcu caaccugcac agcgaggaga acauccagaa gcccuucucc     1440

gccggguuca agcggaccag cacgcugacc gugcaggacc aggaggagcu gugcaacggc     1500

aagugcaaga gcaagcagcu cugccgcucc cagagccugc ugcuccgguc cagcacccgc     1560

cggaacuccu acaucaacac cccggucgcc gagaucauca ugaagcccaa cguggggcag     1620

ggcagcacgu ccgugcagac cgccauggag agcgagcugg gcgaguccag cgcgaccauc     1680

aacaagcgcc ugugcaaguc caccaucgag cucagcgaga acucccugcu gcccgccagc     1740

uccaugcuca cggggaccca gagccugcug cagccccacc ucgagcgggu cgccaucgac     1800

gcccugcagc ugugcugccu ccugcugccg ccgcccaacc gccggaagcu ccagcugcug     1860

augcgcauga ucucccggau gagccagaac guggacaugc ccaagcucca cgacgccaug     1920

ggcacccgca gccugaugau ccacaccuuc ucccggugcg ugcugugcug cgcggaggag     1980

gucgaccucg acgagcugcu ggccgggcgc cucgugagcu uccugaugga ccaccaccag     2040

gagauccucc aggugcccuc cuaccuccag acggccgucg agaagcaccu ggacuaccug     2100

aagaagggcc acaucgagaa ccccggggac ggccucuucg cgccccugcc gaccuacagc     2160

uacugcaagc agaucuccgc ccaggaguuc gacgagcaga aggugagcac cucccaggcc     2220

gccaucgccg agcugcucga gaacaucauc aagaaccgca gccugccccu gaaggagaag     2280

cggaagaagc ucaagcaguu ccagaaggag uacccccuga ucuaccagaa gcgcuucccc     2340

accacggagu ccgaggccgc ccuguucggc gacaagccga ccaucaagca gcccaugcuc     2400

auccugcgga agcccaaguu ccgcagccug cgguga                               2436


<210>  1234
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DEP1A__Homo_sapiens__BAF91373

<400>  1234
auggaguccc agggcguccc ccccggcccc uaccgcgcca ccaagcucug gaacgagguc       60

accaccuccu uccgcgccgg caugccccuc cgcaagcacc gccagcacuu caagaaguac      120

ggcaacugcu ucaccgccgg cgaggccguc gacuggcucu acgaccuccu ccgcaacaac      180

uccaacuucg gccccgaggu cacccgccag cagaccaucc agcuccuccg caaguuccuc      240

aagaaccacg ucaucgagga caucaagggc cgcuggggcu ccgagaacgu cgacgacaac      300

aaccagcucu uccgcuuccc cgccaccucc ccccucaaga cccucccccg ccgcuacccc      360

gagcuccgca agaacaacau cgagaacuuc uccaaggaca aggacuccau cuucaagcuc      420

cgcaaccucu cccgccgcac ccccaagcgc cacggccucc accucuccca ggagaacggc      480

gagaagauca agcacgagau caucaacgag gaccaggaga acgccaucga caaccgcgag      540

cucucccagg aggacgucga ggaggucugg cgcuacguca uccucaucua ccuccagacc      600

auccucggcg uccccucccu cgaggagguc aucaacccca agcaggucau cccccaguac      660

aucauguaca acauggccaa caccuccaag cgcggcgucg ucauccucca gaacaagucc      720

gacgaccucc cccacugggu ccucuccgcc augaagugcc ucgccaacug gccccgcucc      780

aacgacauga acaaccccac cuacgucggc uucgagcgcg acgucuuccg caccaucgcc      840

gacuacuucc ucgaccuccc cgagccccuc cucaccuucg aguacuacga gcucuucguc      900

aacauccucg ucgucugcgg cuacaucacc gucuccgacc gcuccuccgg cauccacaag      960

auccaggacg acccccaguc cuccaaguuc cuccaccuca acaaccucaa cuccuucaag     1020

uccaccgagu gccuccuccu cucccuccuc caccgcgaga agaacaagga ggaguccgac     1080

uccaccgagc gccuccagau cuccaacccc ggcuuccagg agcgcugcgc caagaagaug     1140

cagcucguca accuccgcaa ccgccgcguc uccgccaacg acaucauggg cggcuccugc     1200

cacaaccuca ucggccucuc caacaugcac gaccucuccu ccaacuccaa gccccgcugc     1260

ugcucccucg agggcaucgu cgacgucccc ggcaacuccu ccaaggaggc cuccuccguc     1320

uuccaccagu ccuuccccaa caucgagggc cagaacaaca agcucuuccu cgaguccaag     1380

cccaagcagg aguuccuccu caaccuccac uccgaggaga acauccagaa gcccuucucc     1440

gccggcuuca agcgcaccuc cacccucacc guccaggacc aggaggagcu cugcaacggc     1500

aagugcaagu ccaagcagcu cugccgcucc cagucccucc uccuccgcuc cuccacccgc     1560

cgcaacuccu acaucaacac ccccgucgcc gagaucauca ugaagcccaa cgucggccag     1620

ggcuccaccu ccguccagac cgccauggag uccgagcucg gcgaguccuc cgccaccauc     1680

aacaagcgcc ucugcaaguc caccaucgag cucuccgaga acucccuccu ccccgccucc     1740

uccaugcuca ccggcaccca gucccuccuc cagccccacc ucgagcgcgu cgccaucgac     1800

gcccuccagc ucugcugccu ccuccucccc ccccccaacc gccgcaagcu ccagcuccuc     1860

augcgcauga ucucccgcau gucccagaac gucgacaugc ccaagcucca cgacgccaug     1920

ggcacccgcu cccucaugau ccacaccuuc ucccgcugcg uccucugcug cgccgaggag     1980

gucgaccucg acgagcuccu cgccggccgc cucgucuccu uccucaugga ccaccaccag     2040

gagauccucc agguccccuc cuaccuccag accgccgucg agaagcaccu cgacuaccuc     2100

aagaagggcc acaucgagaa ccccggcgac ggccucuucg ccccccuccc caccuacucc     2160

uacugcaagc agaucuccgc ccaggaguuc gacgagcaga aggucuccac cucccaggcc     2220

gccaucgccg agcuccucga gaacaucauc aagaaccgcu cccucccccu caaggagaag     2280

cgcaagaagc ucaagcaguu ccagaaggag uacccccuca ucuaccagaa gcgcuucccc     2340

accaccgagu ccgaggccgc ccucuucggc gacaagccca ccaucaagca gcccaugcuc     2400

auccuccgca agcccaaguu ccgcucccuc cgcuga                               2436


<210>  1235
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DEP1A__Homo_sapiens__BAF91373

<400>  1235
auggagagcc agggcgugcc cccugggcca uacagagcca ccaagcugug gaacgaaguc       60

acaacuuccu ucagggcugg aaugccgcuc cggaaacacc gccaacauuu uaagaaauau      120

gguaauugcu ucacggcagg cgaggccguu gacuggcuuu acgaucuguu gcgaaacaau      180

ucuaacuuug ggcccgaagu gacccgucag cagacaaucc aguuacugag aaaguuccug      240

aaaaaucacg uaauugagga cauaaaggga agguggggcu cagaaaacgu ggaugacaau      300

aaccaacucu uucgguuccc ugcgaccagu ccacugaaga cucuuccccg cagauauccu      360

gagcugagga aaaauaacau cgagaauuuu agcaaggaua aagacuccau uuucaaguug      420

cggaaccucu cucgccgaac accaaaaaga cauggucugc accugucgca ggaaaauggg      480

gagaagauca agcaugaaau uaucaacgag gaucaggaga augcuauaga caacagggaa      540

cucucacagg aggaugucga agaggugugg cgguacguua ucuuaauuua ucugcaaacc      600

auccuuggag ugcccagcuu ggaagagguc auuaacccua aacaggugau cccacaguac      660

auaauguaua auauggccaa cacaaguaag cguggcguag uuauucugca gaauaaaucc      720

gacgaucuac cgcacugggu gcucucugca augaaguguc uggccaacug gccccgcagc      780

aaugacauga acaauccuac uuacgucggc uuugagagag auguguucag gaccaucgcu      840

gacuacuuuc uugaccugcc agaacccuug cucacguucg aguauuacga acuguuugug      900

aacauuuuag ucguuugcgg guauaucacu guguccgauc ggucaagugg aauccacaaa      960

auucaagacg auccucagag cucuaaguuc cugcaucuca auaaccuuaa uuccuucaaa     1020

ucaaccgagu gucuguugcu aagccugcuc caccgagaaa agaacaagga ggagagugac     1080

ucuacagaac gccugcagau auccaaucca gguuuucaag agagaugcgc caaaaagaug     1140

cagcuuguaa accugaggaa ucggcgcgug agcgcaaacg auaucauggg cgggucgugu     1200

cauaacuuga uuggacucuc uaauaugcac gaccuguccu caaacaguaa acccagaugc     1260

uguagcuuag aaggcaucgu cgaugugccg gguaauuccu cuaaggaggc uagcucaguu     1320

uuccaccaga guuuuccuaa cauagaaggg cagaauaaca aacuguuccu agaguccaag     1380

cccaagcaag aguuucuccu gaaucuucau agcgaagaga acauucagaa accauucucu     1440

gccggauuua agaggacuuc aaccuugaca gugcaggacc aggaggaacu gugcaauggc     1500

aaauguaaga guaaacaacu cugccguagc cagucccugc uucugcgguc uucgacccga     1560

agaaacagcu acaucaauac gccugucgcg gagaucauua ugaagcccaa cgugggccag     1620

ggguccacuu caguacagac agcaauggaa agugaguugg gagaaucuag cgccaccauc     1680

aauaagaggc ucuguaaauc cacuauugag cugucagaaa acagcuuacu gccagcuucu     1740

uccaugcuaa cagguaccca aagucuccug cagccccacc uugagcgcgu ugccauagau     1800

gcauugcagc ugugcugccu ccuguuaccu ccaccgaauc ggagaaagcu gcagcuuuug     1860

augaggauga ucagccgcau gucucaaaac guggacaugc ccaaacucca ugaugcuaug     1920

ggcacgcgau cccugaugau ucacaccuuc ucacggugug uccuaugcug ugccgaggaa     1980

guggaccugg acgagcuccu ggcggggcgu cuugucagcu uuuugaugga ucaucaccag     2040

gaaauccuac aggugccuag uuauuuacaa acagccguug agaagcaccu cgacuaccug     2100

aaaaagggac auaucgaaaa cccaggcgau ggucuuuucg caccccugcc uacuuauucg     2160

uacugcaagc agauuuccgc ucaggaguuu gacgagcaga aagugucuac cagccaagcc     2220

gcuauagccg aauugcucga gaauaucauu aagaacagau cacugccacu aaaagaaaag     2280

aggaaaaagc ugaaacaguu ccagaaggag uacccccuca ucuaucagaa gcgcuuuccg     2340

acaacugaaa gugaggcagc ccuguucggg gauaaaccua ccauuaagca accaaugcuu     2400

aucuugcgga aacccaaguu cagaucccug agguga                               2436


<210>  1236
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DEP1A__Homo_sapiens__BAF91373

<400>  1236
auggagagcc agggcgugcc ccccggcccc uacagagcca ccaagcugug gaacgaggug       60

accaccagcu ucagagccgg caugccccug agaaagcaca gacagcacuu caagaaguac      120

ggcaacugcu ucaccgccgg cgaggccgug gacuggcugu acgaccugcu gagaaacaac      180

agcaacuucg gccccgaggu gaccagacag cagaccaucc agcugcugag aaaguuccug      240

aagaaccacg ugaucgagga caucaagggc agauggggca gcgagaacgu ggacgacaac      300

aaccagcugu ucagauuccc cgccaccagc ccccugaaga cccugcccag aagauacccc      360

gagcugagaa agaacaacau cgagaacuuc agcaaggaca aggacagcau cuucaagcug      420

agaaaccuga gcagaagaac ccccaagaga cacggccugc accugagcca ggagaacggc      480

gagaagauca agcacgagau caucaacgag gaccaggaga acgccaucga caacagagag      540

cugagccagg aggacgugga ggaggugugg agauacguga uccugaucua ccugcagacc      600

auccugggcg ugcccagccu ggaggaggug aucaacccca agcaggugau cccccaguac      660

aucauguaca acauggccaa caccagcaag agaggcgugg ugauccugca gaacaagagc      720

gacgaccugc cccacugggu gcugagcgcc augaagugcc uggccaacug gcccagaagc      780

aacgacauga acaaccccac cuacgugggc uucgagagag acguguucag aaccaucgcc      840

gacuacuucc uggaccugcc cgagccccug cugaccuucg aguacuacga gcuguucgug      900

aacauccugg uggugugcgg cuacaucacc gugagcgaca gaagcagcgg cauccacaag      960

auccaggacg acccccagag cagcaaguuc cugcaccuga acaaccugaa cagcuucaag     1020

agcaccgagu gccugcugcu gagccugcug cacagagaga agaacaagga ggagagcgac     1080

agcaccgaga gacugcagau cagcaacccc ggcuuccagg agagaugcgc caagaagaug     1140

cagcugguga accugagaaa cagaagagug agcgccaacg acaucauggg cggcagcugc     1200

cacaaccuga ucggccugag caacaugcac gaccugagca gcaacagcaa gcccagaugc     1260

ugcagccugg agggcaucgu ggacgugccc ggcaacagca gcaaggaggc cagcagcgug     1320

uuccaccaga gcuuccccaa caucgagggc cagaacaaca agcuguuccu ggagagcaag     1380

cccaagcagg aguuccugcu gaaccugcac agcgaggaga acauccagaa gcccuucagc     1440

gccggcuuca agagaaccag cacccugacc gugcaggacc aggaggagcu gugcaacggc     1500

aagugcaaga gcaagcagcu gugcagaagc cagagccugc ugcugagaag cagcaccaga     1560

agaaacagcu acaucaacac ccccguggcc gagaucauca ugaagcccaa cgugggccag     1620

ggcagcacca gcgugcagac cgccauggag agcgagcugg gcgagagcag cgccaccauc     1680

aacaagagac ugugcaagag caccaucgag cugagcgaga acagccugcu gcccgccagc     1740

agcaugcuga ccggcaccca gagccugcug cagccccacc uggagagagu ggccaucgac     1800

gcccugcagc ugugcugccu gcugcugccc ccccccaaca gaagaaagcu gcagcugcug     1860

augagaauga ucagcagaau gagccagaac guggacaugc ccaagcugca cgacgccaug     1920

ggcaccagaa gccugaugau ccacaccuuc agcagaugcg ugcugugcug cgccgaggag     1980

guggaccugg acgagcugcu ggccggcaga cuggugagcu uccugaugga ccaccaccag     2040

gagauccugc aggugcccag cuaccugcag accgccgugg agaagcaccu ggacuaccug     2100

aagaagggcc acaucgagaa ccccggcgac ggccuguucg ccccccugcc caccuacagc     2160

uacugcaagc agaucagcgc ccaggaguuc gacgagcaga aggugagcac cagccaggcc     2220

gccaucgccg agcugcugga gaacaucauc aagaacagaa gccugccccu gaaggagaag     2280

agaaagaagc ugaagcaguu ccagaaggag uacccccuga ucuaccagaa gagauucccc     2340

accaccgaga gcgaggccgc ccuguucggc gacaagccca ccaucaagca gcccaugcug     2400

auccugagaa agcccaaguu cagaagccug agauga                               2436


<210>  1237
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DEP1A__Homo_sapiens__BAF91373

<400>  1237
auggagagcc agggcgugcc cccugggccg uacagagcca ccaagcugug gaacgaaguc       60

acaacguccu uccgggcugg aaugccccuc cgcaaacaca gacaacauuu uaagaaauau      120

ggcaauugcu ucaccgccgg ggaggcgguu gacuggcugu acgaucuucu gcggaacaau      180

ucuaacuuug gaccugaagu gacacgccag cagaccaucc agcuccugag aaaguuccuu      240

aaaaaucacg ugauugagga caucaagggc cgguggggga gcgaaaacgu cgaugacaau      300

aaccaacugu uucgcuuccc cgcuacaucc ccucucaaga cccugcccag acgguauccu      360

gagcugcgca aaaauaacau ugagaauuuu ucuaaggaua aagacagcau cuucaagcuc      420

agaaaccugu cccggcgcac accgaaaaga cauggacuuc accugucuca ggaaaauggc      480

gagaagauua agcaugaaau caucaacgag gaucaggaga augccauuga caaccgggaa      540

cucagccagg aggaugugga agagguuugg cgcuacguga uccugauuua ucuucaaacc      600

auccugggcg uccccucccu cgaagaggug auuaacccua aacagguuau cccccaguac      660

auuauguaua auauggccaa cacgagcaag agaggggugg ucauccugca gaauaaaucu      720

gacgaucugc cucacugggu gcucuccgcu augaaguguc uggccaacug gccccggagc      780

aaugacauga acaauccgac cuacguggga uuugagagag augucuuccg cacaaucgcu      840

gacuacuuuc uugaccugcc ugaaccccuc cugaccuucg aguauuacga acuuuuuguu      900

aacauucugg uggugugcgg cuauaucaca gucucugauc gguccagcgg gauucacaaa      960

auccaagacg auccucaguc uuccaaguuc cuccaucuga auaaccugaa uagcuucaaa     1020

uccaccgagu gucuccugcu uucucugcuc cacagagaaa agaacaagga ggagagcgac     1080

uccacggaac gccugcagau uagcaauccc ggauuucaag agcggugcgc caaaaagaug     1140

cagcuuguga accugagaaa ucgccggguu ucugcgaacg auaucauggg cggguccugu     1200

cauaaccuca ucggacugag caauaugcac gaccugucua gcaacuccaa acccagaugc     1260

uguucucucg aaggcauugu ggaugucccu ggcaauagcu ccaaggaggc cagcucugug     1320

uuccaccagu ccuuuccgaa caucgaaggg cagaauaaca aacuguuccu ugagagcaag     1380

cccaagcaag aguuucugcu caaucugcau ucugaagaga acauucagaa accuuucucc     1440

gcuggauuua agcgcacaag cacccugaca guucaggacc aggaggaacu uugcaauggc     1500

aaauguaagu ccaaacaacu cugccggucu cagagccugc ugcucagauc cucuacccgc     1560

cggaacagcu acaucaauac ccccguggcc gagauuauca ugaagccuaa cgucgggcag     1620

ggauccacaa gcgugcagac ggcuauggaa ucugagcugg gcgaauccag cgccaccauc     1680

aauaagagac uuuguaaauc uacaauugag cuguccgaaa acagccuccu gcccgcgucu     1740

agcaugcuga ccgggacaca aucccuucuc cagccgcacc uggagcgggu cgccaucgau     1800

gcucugcagc ucugcugccu gcuucugccu cccccuaauc gcagaaagcu ccagcugcug     1860

augcggauga uuagcagaau gucucaaaac guggacaugc ccaaacuuca ugaugccaug     1920

ggaacccgcu cccucaugau ccacacguuc agccggugug uucugugcug ugcugaggaa     1980

guggaccugg acgagcuccu ggccggcaga cuugucuccu uucugaugga ucaucaccag     2040

gaaauucucc aggugccuuc uuaucugcaa acagccguug agaagcaccu ggacuaccuu     2100

aaaaagggcc auaucgaaaa ccccggggau ggacucuucg cuccgcugcc uaccuauagc     2160

uacugcaagc agauuuccgc gcaggaguuu gacgagcaga aagugucuac cagccaagcc     2220

gcuaucgccg aacugcucga gaauaucauu aagaaccgcu cccugccccu uaaagaaaag     2280

cggaaaaagc ugaaacaguu ccagaaggag uacccccuca ucuaucagaa gagauuuccu     2340

acaaccgaau cugaggccgc ucuguucggc gauaaaccga caauuaagca acccaugcug     2400

auccuucgca aaccuaaguu cagaagccug cgguga                               2436


<210>  1238
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_16__P03129

<400>  1238

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  1239
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_16__AAA46940

<400>  1239
augcauggag auacaccuac auugcaugaa uauauguuag auuugcaacc agagacaacu       60

gaucucuacu guuaugagca auuaaaugac agcucagagg aggaggauga aauagauggu      120

ccagcuggac aagcagaacc ggacagagcc cauuacaaua uuguaaccuu uuguugcaag      180

ugugacucua cgcuucgguu gugcguacaa agcacacacg uagacauucg uacuuuggaa      240

gaccuguuaa ugggcacacu aggaauugug ugccccaucu guucucagaa accauaa         297


<210>  1240
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_16__AAA46940

<400>  1240
augcacggcg acacccccac ccugcacgag uacaugcucg accugcagcc ggagacgacc       60

gaccuguacu gcuacgagca gcucaacgac agcuccgagg aggaggacga gaucgacggg      120

cccgccggcc aggccgagcc cgaccgcgcg cacuacaaca ucgugaccuu cugcugcaag      180

ugcgacagca cccugcggcu gugcguccag uccacgcacg uggacauccg cacccucgag      240

gaccugcuga uggggacccu cggcaucgug ugccccaucu gcagccagaa gccguga         297


<210>  1241
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_16__AAA46940

<400>  1241
augcacggcg acacccccac ccuccacgag uacaugcucg accuccagcc cgagaccacc       60

gaccucuacu gcuacgagca gcucaacgac uccuccgagg aggaggacga gaucgacggc      120

cccgccggcc aggccgagcc cgaccgcgcc cacuacaaca ucgucaccuu cugcugcaag      180

ugcgacucca cccuccgccu cugcguccag uccacccacg ucgacauccg cacccucgag      240

gaccuccuca ugggcacccu cggcaucguc ugccccaucu gcucccagaa gcccuga         297


<210>  1242
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_16__AAA46940

<400>  1242
augcacggcg acacccccac acugcaugag uacaugcucg aucuucagcc ugaaacuacg       60

gaccuguauu gcuacgagca auugaacgau agcuccgaag aggaagacga gaucgauggg      120

ccagccggac aggcugagcc ggacagagca cacuauaaua uugugaccuu cuguugcaag      180

ugugauucua cauuaaggcu gugcguccag ucaacucaug uugacauacg gacccuagaa      240

gaucuccuga uggguacacu uggcaucgug ugucccauuu gcagucagaa accuuga         297


<210>  1243
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_16__AAA46940

<400>  1243
augcacggcg acacccccac ccugcacgag uacaugcugg accugcagcc cgagaccacc       60

gaccuguacu gcuacgagca gcugaacgac agcagcgagg aggaggacga gaucgacggc      120

cccgccggcc aggccgagcc cgacagagcc cacuacaaca ucgugaccuu cugcugcaag      180

ugcgacagca cccugagacu gugcgugcag agcacccacg uggacaucag aacccuggag      240

gaccugcuga ugggcacccu gggcaucgug ugccccaucu gcagccagaa gcccuga         297


<210>  1244
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_16__AAA46940

<400>  1244
augcacggcg acacccccac acugcaugag uacaugcucg aucugcagcc ugaaacgacc       60

gaccuuuauu gcuacgagca acugaacgau agcuccgaag aggaagacga gaucgauggg      120

ccggccggac aggcugagcc cgacagagcc cacuauaaua uugugacauu cuguugcaag      180

ugugauucua cccuccggcu gugcguccag agcacacaug uugacauccg cacccuugaa      240

gaucugcuca ugggcacacu ggggauugug uguccuaucu gcucccagaa acccuga         297


<210>  1245
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_18__P06788

<400>  1245

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  1246
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_18__AAA46947

<400>  1246
augcauggac cuaaggcaac auugcaagac auuguauugc auuuagagcc ccaaaaugaa       60

auuccgguug accuucuaug ucacgagcaa uuaagcgacu cagaggaaga aaacgaugaa      120

auagauggag uuaaucauca acauuuacca gcccgacgag cugaaccaca acgucacaca      180

auguugugua uguguuguaa gugugaagcc agaauuaagc uaguaguaga aagcucagca      240

gacgaccuuc gagcauucca gcagcuguuu cugaacaccc uguccuuugu guguccgugg      300

ugugcauccc agcaguaa                                                    318


<210>  1247
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_18__AAA46947

<400>  1247
augcacggcc ccaaggccac ccugcaggac aucgugcucc accuggagcc gcagaacgag       60

auccccgucg accugcucug ccacgagcag cugagcgacu ccgaggagga gaacgacgag      120

aucgacgggg ugaaccacca gcaccucccc gcccgccggg cggagcccca gcgccacacc      180

augcucugca ugugcugcaa gugcgaggcc cggaucaagc ugguggucga gagcuccgcc      240

gacgaccugc gcgccuucca gcagcuguuc cugaacacgc ugagcuucgu gugcccgugg      300

ugcgccuccc agcaguga                                                    318


<210>  1248
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_18__AAA46947

<400>  1248
augcacggcc ccaaggccac ccuccaggac aucguccucc accucgagcc ccagaacgag       60

auccccgucg accuccucug ccacgagcag cucuccgacu ccgaggagga gaacgacgag      120

aucgacggcg ucaaccacca gcaccucccc gcccgccgcg ccgagcccca gcgccacacc      180

augcucugca ugugcugcaa gugcgaggcc cgcaucaagc ucgucgucga guccuccgcc      240

gacgaccucc gcgccuucca gcagcucuuc cucaacaccc ucuccuucgu cugccccugg      300

ugcgccuccc agcaguga                                                    318


<210>  1249
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_18__AAA46947

<400>  1249
augcacggcc ccaaggccac ccugcaggac aucgugcucc aucuugagcc ucaaaacgaa       60

auuccagucg aucuguugug ccacgagcag uuaagcgacu ccgaagagga aaaugaugag      120

auagacgggg uuaaccauca gcaucugccg gcuagaaggg cagagcccca gcggcacaca      180

augcuaugua ugugcuguaa augcgaagcc cgcaucaagc ucgugguaga gucuucagcg      240

gaugaccugc gagcuuucca acagcuuuuu cugaauacuu ugaguuucgu guguccuugg      300

ugcgccagcc agcaguga                                                    318


<210>  1250
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_18__AAA46947

<400>  1250
augcacggcc ccaaggccac ccugcaggac aucgugcugc accuggagcc ccagaacgag       60

auccccgugg accugcugug ccacgagcag cugagcgaca gcgaggagga gaacgacgag      120

aucgacggcg ugaaccacca gcaccugccc gccagaagag ccgagcccca gagacacacc      180

augcugugca ugugcugcaa gugcgaggcc agaaucaagc ugguggugga gagcagcgcc      240

gacgaccuga gagccuucca gcagcuguuc cugaacaccc ugagcuucgu gugccccugg      300

ugcgccagcc agcaguga                                                    318


<210>  1251
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_18__AAA46947

<400>  1251
augcacggcc ccaaggccac ccugcaggac aucgugcucc aucuggagcc ucaaaacgaa       60

auuccggucg aucuucugug ccacgagcag cucagcgacu ccgaagagga aaaugaugag      120

aucgacgggg uuaaccauca gcaucugccc gcuagacggg ccgagccuca gcgccacaca      180

augcuuugua ugugcuguaa augcgaagcg agaauuaagc ugguggugga gucuagcgcu      240

gaugaccucc gggccuucca acagcuguuu cugaauacgc ucuccuucgu cugucccugg      300

ugcgccucuc agcaguga                                                    318


<210>  1252
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_31__P17387

<400>  1252

Met Arg Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Ala Thr Asp Leu His Cys Tyr Glu Gln Leu Pro Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Lys Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
65                  70                  75                  80  


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
                85                  90                  95      


Arg Leu 
        


<210>  1253
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_31__AAA46951

<400>  1253
augcguggag aaacaccuac guugcaagac uauguguuag auuugcaacc ugaggcaacu       60

gaccuccacu guuaugagca auuacccgac agcucagaug aggaggaugu cauagacagu      120

ccagcuggac aagcagaacc ggacacaucc aauuacaaua ucguuaccuu uuguugucag      180

uguaagucua cacuucguuu guguguacag agcacacaag uagauauucg cauauugcaa      240

gagcuguuaa ugggcucauu uggaaucgug ugccccaacu guucuacuag acuguaa         297


<210>  1254
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_31__AAA46951

<400>  1254
augcgcggcg agacccccac ccugcaggac uacgugcucg accugcagcc ggaggccacg       60

gaccugcacu gcuacgagca gcuccccgac agcuccgacg aggaggacgu caucgacagc      120

cccgccgggc aggcggagcc cgacaccucc aacuacaaca ucgugaccuu cugcugccag      180

ugcaagagca cccugcggcu gugcgugcag uccacgcagg ucgacauccg cauccuccag      240

gagcugcuga ugggcagcuu cgggaucgug ugcccgaacu gcuccacccg gcucuga         297


<210>  1255
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_31__AAA46951

<400>  1255
augcgcggcg agacccccac ccuccaggac uacguccucg accuccagcc cgaggccacc       60

gaccuccacu gcuacgagca gcuccccgac uccuccgacg aggaggacgu caucgacucc      120

cccgccggcc aggccgagcc cgacaccucc aacuacaaca ucgucaccuu cugcugccag      180

ugcaagucca cccuccgccu cugcguccag uccacccagg ucgacauccg cauccuccag      240

gagcuccuca ugggcuccuu cggcaucguc ugccccaacu gcuccacccg ccucuga         297


<210>  1256
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_31__AAA46951

<400>  1256
augagaggcg agacccccac acugcaggac uacgugcucg aucuucaacc ugaagccacu       60

gaccugcacu gcuaugagca guugccagau agcuccgacg aagaggaugu caucgacucu      120

ccggcugggc aggcagaacc cgauacguca aacuacaaua uuguuaccuu cuguugccag      180

uguaagagua cauuaaggcu gugcgugcaa agcacucagg uagacauacg gauccuacag      240

gagcuccuga ugggauccuu ugguauugug uguccuaacu gcucuacccg ccuuuga         297


<210>  1257
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_31__AAA46951

<400>  1257
augagaggcg agacccccac ccugcaggac uacgugcugg accugcagcc cgaggccacc       60

gaccugcacu gcuacgagca gcugcccgac agcagcgacg aggaggacgu gaucgacagc      120

cccgccggcc aggccgagcc cgacaccagc aacuacaaca ucgugaccuu cugcugccag      180

ugcaagagca cccugagacu gugcgugcag agcacccagg uggacaucag aauccugcag      240

gagcugcuga ugggcagcuu cggcaucgug ugccccaacu gcagcaccag acuguga         297


<210>  1258
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_31__AAA46951

<400>  1258
augagaggcg agacccccac acugcaggac uacgugcucg aucugcaacc ugaagccacg       60

gaccuucacu gcuaugagca gcugccggau agcuccgacg aagaggaugu caucgacucu      120

cccgcugggc aggccgaacc ugauaccagc aacuacaaua uuguuacauu cuguugccag      180

uguaagucca cccuccggcu gugcgugcaa ucuacacagg uggacauccg cauucuucag      240

gagcugcuca ugggcagcuu uggaaucguc ugucccaacu gcuccaccag acuguga         297


<210>  1259
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_33__P06429

<400>  1259

Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Val Leu Asp Leu Tyr 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala 
        35                  40                  45              


Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr 
    50                  55                  60                  


Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln 
65                  70                  75                  80  


Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Thr Cys Ala Gln 
                85                  90                  95      


Gln 
    


<210>  1260
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_33__AAA46959

<400>  1260
augagaggac acaagccaac guuaaaggaa uauguuuuag auuuauaucc ugaaccaacu       60

gaccuauacu gcuaugagca auuaagugac agcucagaug aggaugaagg cuuggaccgg      120

ccagauggac aagcacaacc agccacagcu gauuacuaca uuguaaccug uugucacacu      180

uguaacacca caguucguuu augugucaac aguacagcaa gugaccuacg aaccauacag      240

caacuacuua ugggcacagu gaauauugug ugcccuaccu gugcacaaca auaa            294


<210>  1261
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_33__AAA46959

<400>  1261
augcgcggcc acaagcccac ccugaaggag uacgugcucg accuguaccc ggagcccacc       60

gaccuguacu gcuacgagca gcucagcgac uccagcgacg aggacgaggg gcuggaccgg      120

cccgacggcc aggcccagcc cgccacggcg gacuacuaca ucgugaccug cugccacacg      180

ugcaacacca ccguccgccu gugcgugaac uccaccgcca gcgaccuccg gaccauccag      240

cagcugcuga uggggaccgu caacaucgug ugcccgacgu gcgcccagca guga            294


<210>  1262
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_33__AAA46959

<400>  1262
augcgcggcc acaagcccac ccucaaggag uacguccucg accucuaccc cgagcccacc       60

gaccucuacu gcuacgagca gcucuccgac uccuccgacg aggacgaggg ccucgaccgc      120

cccgacggcc aggcccagcc cgccaccgcc gacuacuaca ucgucaccug cugccacacc      180

ugcaacacca ccguccgccu cugcgucaac uccaccgccu ccgaccuccg caccauccag      240

cagcuccuca ugggcaccgu caacaucguc ugccccaccu gcgcccagca guga            294


<210>  1263
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_33__AAA46959

<400>  1263
augagaggcc acaagcccac ccugaaagag uacgugcucg accuuuaucc ugaaccaaca       60

gaucuguacu gcuaugagca guugagcgac uccucugaug aagacgaggg guuagauagg      120

ccggacggac aagcccagcc cgcuacugca gauuacuaua ucgucacgug uugccauacc      180

uguaacacaa cuguucggcu gugcguaaau ucaaccgcca gugaccuacg cacaauucag      240

cagcuccuga uggguaccgu gaacauagug uguccuacuu gcgcgcaaca guga            294


<210>  1264
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_33__AAA46959

<400>  1264
augagaggcc acaagcccac ccugaaggag uacgugcugg accuguaccc cgagcccacc       60

gaccuguacu gcuacgagca gcugagcgac agcagcgacg aggacgaggg ccuggacaga      120

cccgacggcc aggcccagcc cgccaccgcc gacuacuaca ucgugaccug cugccacacc      180

ugcaacacca ccgugagacu gugcgugaac agcaccgcca gcgaccugag aaccauccag      240

cagcugcuga ugggcaccgu gaacaucgug ugccccaccu gcgcccagca guga            294


<210>  1265
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_33__AAA46959

<400>  1265
augagaggcc acaagcccac ccugaaagag uacgugcucg accuguaucc ugaaccgaca       60

gaucuuuacu gcuaugagca gcugagcgac uccucugaug aagacgaggg gcucgaucgg      120

cccgacggac aagcccagcc ugcuacggcc gauuacuaua ucgucaccug uugccauaca      180

uguaacacca caguucgccu gugcgugaau agcaccgcgu ccgaccuuag aacaauucag      240

cagcugcuca ugggcaccgu gaacaucguc ugucccacgu gcgcucaaca guga            294


<210>  1266
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_35__P27230

<400>  1266

Met His Gly Glu Ile Thr Thr Leu Gln Asp Tyr Val Leu Asp Leu Glu 
1               5                   10                  15      


Pro Glu Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Cys Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Glu Asp Thr Ile Asp Gly Pro Ala Gly Gln Ala Lys Pro 
        35                  40                  45              


Asp Thr Ser Asn Tyr Asn Ile Val Thr Ser Cys Cys Lys Cys Glu Ala 
    50                  55                  60                  


Thr Leu Arg Leu Cys Val Gln Ser Thr His Ile Asp Ile Arg Lys Leu 
65                  70                  75                  80  


Glu Asp Leu Leu Met Gly Thr Phe Gly Ile Val Cys Pro Gly Cys Ser 
                85                  90                  95      


Gln Arg Ala 
            


<210>  1267
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_35__AAA46967

<400>  1267
augcauggag aaauaacuac auugcaagac uauguuuuag auuuggaacc cgaggcaacu       60

gaccuauacu guuaugagca auugugugac agcucagagg aggaggaaga uacuauugac      120

gguccagcug gacaagcaaa accagacacc uccaauuaua auauuguaac guccuguugu      180

aaaugugagg cgacacuacg ucugugugua cagagcacac acauugacau acguaaauug      240

gaagauuuau uaaugggcac auuuggaaua gugugccccg gcuguucaca gagagcauaa      300


<210>  1268
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_35__AAA46967

<400>  1268
augcacggcg agaucaccac ccugcaggac uacgugcucg accuggagcc cgaggccacg       60

gaccuguacu gcuacgagca gcucugcgac agcuccgagg aggaggagga caccaucgac      120

gggccggccg gccaggcgaa gcccgacacc agcaacuaca acaucgucac cuccugcugc      180

aagugcgagg ccacgcugcg ccugugcgug cagagcaccc acaucgacau ccggaagcuc      240

gaggaccugc ugauggggac cuucggcauc gugugccccg ggugcuccca gcgcgccuga      300


<210>  1269
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_35__AAA46967

<400>  1269
augcacggcg agaucaccac ccuccaggac uacguccucg accucgagcc cgaggccacc       60

gaccucuacu gcuacgagca gcucugcgac uccuccgagg aggaggagga caccaucgac      120

ggccccgccg gccaggccaa gcccgacacc uccaacuaca acaucgucac cuccugcugc      180

aagugcgagg ccacccuccg ccucugcguc caguccaccc acaucgacau ccgcaagcuc      240

gaggaccucc ucaugggcac cuucggcauc gucugccccg gcugcuccca gcgcgccuga      300


<210>  1270
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_35__AAA46967

<400>  1270
augcacggcg agaucaccac acugcaggac uacgugcucg aucuugaacc cgaggccacu       60

gaccuguauu gcuacgaaca auugugugau agcuccgagg aagaggagga cacgauugau      120

gggccugcug gacaggcaaa gccagacacc ucuaacuaua auauagucac aucaugcugu      180

aaaugcgaag ccacuuuaag acuguguguu cagaguaccc auaucgauau uaggaagcua      240

gaggaccucc ugauggguac auucggcauc gugugcccgg gguguagcca gcgggcguga      300


<210>  1271
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_35__AAA46967

<400>  1271
augcacggcg agaucaccac ccugcaggac uacgugcugg accuggagcc cgaggccacc       60

gaccuguacu gcuacgagca gcugugcgac agcagcgagg aggaggagga caccaucgac      120

ggccccgccg gccaggccaa gcccgacacc agcaacuaca acaucgugac cagcugcugc      180

aagugcgagg ccacccugag acugugcgug cagagcaccc acaucgacau cagaaagcug      240

gaggaccugc ugaugggcac cuucggcauc gugugccccg gcugcagcca gagagccuga      300


<210>  1272
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_35__AAA46967

<400>  1272
augcacggcg agaucaccac acugcaggac uacgugcucg aucuggaacc cgaggccacg       60

gaccuuuauu gcuacgaaca acugugugau agcuccgagg aagaggagga caccauugau      120

gggccugcug gacaggccaa gccggacaca ucuaacuaua auaucgucac cagcugcugu      180

aagugcgaag cgacacucag acuguguguu caguccaccc auauugauau ccggaaacuu      240

gaggaccugc ucaugggcac auucgggauu gugugccccg gauguucuca gcgcgcuuga      300


<210>  1273
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_39__P24837

<400>  1273

Met Arg Gly Pro Lys Pro Thr Leu Gln Glu Ile Val Leu Asp Leu Cys 
1               5                   10                  15      


Pro Tyr Asn Glu Ile Gln Pro Val Asp Leu Val Cys His Glu Gln Leu 
            20                  25                  30          


Gly Glu Ser Glu Asp Glu Ile Asp Glu Pro Asp His Ala Val Asn His 
        35                  40                  45              


Gln His Gln Leu Leu Ala Arg Arg Asp Glu Pro Gln Arg His Thr Ile 
    50                  55                  60                  


Gln Cys Ser Cys Cys Lys Cys Asn Asn Thr Leu Gln Leu Val Val Glu 
65                  70                  75                  80  


Ala Ser Arg Asp Thr Leu Arg Gln Leu Gln Gln Leu Phe Met Asp Ser 
                85                  90                  95      


Leu Gly Phe Val Cys Pro Trp Cys Ala Thr Ala Asn Gln 
            100                 105                 


<210>  1274
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_39__AAA47051

<400>  1274
augcguggac caaagcccac cuugcaggaa auuguauuag auuuaugucc uuacaaugaa       60

auacagccgg uugaccuugu augucacgag caauuaggag agucagagga ugaaauagau      120

gaacccgacc augcaguuaa ucaccaacau caacuacuag ccagacggga ugaaccacag      180

cgucacacaa uacaguguuc guguuguaag uguaacaaca cacugcagcu gguaguagaa      240

gccucacggg auacucugcg acaacuacag cagcuguuua uggacucacu aggauuugug      300

uguccguggu gugcaacugc aaaccaguaa                                       330


<210>  1275
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_39__AAA47051

<400>  1275
augcgcggcc ccaagccgac ccugcaggag aucgugcucg accugugccc cuacaacgag       60

auccagcccg ucgaccuggu gugccacgag cagcucgggg agagcgagga cgagaucgac      120

gagcccgacc acgccgugaa ccaccagcac cagcugcugg cccggcgcga cgagccgcag      180

cggcacacca uccagugcuc cugcugcaag ugcaacaaca cgcuccagcu ggucguggag      240

gcgagccgcg acacccugcg gcagcuccag cagcuguuca uggacucccu gggcuucgug      300

ugccccuggu gcgccaccgc caaccaguga                                       330


<210>  1276
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_39__AAA47051

<400>  1276
augcgcggcc ccaagcccac ccuccaggag aucguccucg accucugccc cuacaacgag       60

auccagcccg ucgaccucgu cugccacgag cagcucggcg aguccgagga cgagaucgac      120

gagcccgacc acgccgucaa ccaccagcac cagcuccucg cccgccgcga cgagccccag      180

cgccacacca uccagugcuc cugcugcaag ugcaacaaca cccuccagcu cgucgucgag      240

gccucccgcg acacccuccg ccagcuccag cagcucuuca uggacucccu cggcuucguc      300

ugccccuggu gcgccaccgc caaccaguga                                       330


<210>  1277
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_39__AAA47051

<400>  1277
augagaggcc ccaagccuac ccugcaggag aucgugcucg accuuugccc auacaacgaa       60

auucaaccgg ucgaucuggu uugucacgag caguuggggg aaagcgagga cgaaauagau      120

gagcccgacc augccgugaa ucaccagcau caguuacugg cuaggcggga ugagccucaa      180

cgccacacaa uccagugcuc cuguugcaaa uguaacaaua cucuacagcu cguaguggaa      240

gcaucucgag acacgcugcg ucagcuucaa cagcuguuca uggauucauu gggauuuguc      300

ugcccauggu gugccaccgc gaaccaguga                                       330


<210>  1278
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_39__AAA47051

<400>  1278
augagaggcc ccaagcccac ccugcaggag aucgugcugg accugugccc cuacaacgag       60

auccagcccg uggaccuggu gugccacgag cagcugggcg agagcgagga cgagaucgac      120

gagcccgacc acgccgugaa ccaccagcac cagcugcugg ccagaagaga cgagccccag      180

agacacacca uccagugcag cugcugcaag ugcaacaaca cccugcagcu ggugguggag      240

gccagcagag acacccugag acagcugcag cagcuguuca uggacagccu gggcuucgug      300

ugccccuggu gcgccaccgc caaccaguga                                       330


<210>  1279
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_39__AAA47051

<400>  1279
augagaggcc ccaagccuac ccugcaggag aucgugcucg accugugccc guacaacgaa       60

auucaacccg ucgaucuugu uugucacgag cagcuggggg aaagcgagga cgaaaucgau      120

gagccugacc augccgugaa ucaccagcau cagcuccugg cucggcgcga ugagccccaa      180

agacacacaa uucagugcuc cuguugcaaa uguaacaaua cgcuucagcu gguggucgaa      240

gccucucggg acacccuccg ccagcugcaa cagcuguuca uggauagccu cggauuugug      300

ugcccuuggu gugcgacagc uaaccaguga                                       330


<210>  1280
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_45__P21736

<400>  1280

Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu 
            20                  25                  30          


Ser Glu Ser Glu Glu Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala 
        35                  40                  45              


Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys 
    50                  55                  60                  


Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser 
65                  70                  75                  80  


Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser 
                85                  90                  95      


Phe Val Cys Pro Trp Cys Ala Thr Asn Gln 
            100                 105     


<210>  1281
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_45__CAA52574

<400>  1281
augcauggac cccgggaaac acugcaagaa auuguauugc auuuggaacc ucagaaugaa       60

uuagauccug uugaccuguu guguuacgag caauuaagcg agucagagga ggaaaacgau      120

gaagcagaug gaguuaguca ugcacaacua ccagcccgac gagccgaacc acagcgucac      180

aaaauuuugu guguauguug uaagugugac ggcagaauug agcuuacagu agagagcucg      240

gcagaggacc uuagaacacu acagcagcug uuuuugagca ccuuguccuu uguguguccg      300

uggugugcaa cuaaccaaua a                                                321


<210>  1282
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_45__CAA52574

<400>  1282
augcacggcc cccgcgagac ccugcaggag aucgugcucc accuggagcc gcagaacgag       60

cuggaccccg ucgaccuccu gugcuacgag cagcugagcg aguccgagga ggagaacgac      120

gaggccgacg gggugagcca cgcccagcuc cccgcgcggc gcgccgagcc ccagcggcac      180

aagauccugu gcgugugcug caagugcgac ggccgcaucg agcugaccgu cgaguccagc      240

gccgaggacc uccggacgcu gcagcagcug uuccucucca cccugagcuu cgugugcccg      300

uggugcgcca ccaaccagug a                                                321


<210>  1283
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_45__CAA52574

<400>  1283
augcacggcc cccgcgagac ccuccaggag aucguccucc accucgagcc ccagaacgag       60

cucgaccccg ucgaccuccu cugcuacgag cagcucuccg aguccgagga ggagaacgac      120

gaggccgacg gcgucuccca cgcccagcuc cccgcccgcc gcgccgagcc ccagcgccac      180

aagauccucu gcgucugcug caagugcgac ggccgcaucg agcucaccgu cgaguccucc      240

gccgaggacc uccgcacccu ccagcagcuc uuccucucca cccucuccuu cgucugcccc      300

uggugcgcca ccaaccagug a                                                321


<210>  1284
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_45__CAA52574

<400>  1284
augcacggcc ccagagagac ccugcaggaa aucgugcucc aucuugagcc ucaaaacgaa       60

cuggacccag ucgauuuguu augcuacgag cagcugagcg aauccgagga ggaaaaugac      120

gaggccgaug ggguuucuca cgcucagcua ccggcaaggc gggccgaacc ccagcgccau      180

aagauucucu gugugugcug uaaaugcgac ggacgaauag agcugacagu agagucaagu      240

gcggaagauc uucguacucu gcaacaguug uuccucagca cgcuguccuu uguguguccu      300

uggugcgcua ccaaccagug a                                                321


<210>  1285
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_45__CAA52574

<400>  1285
augcacggcc ccagagagac ccugcaggag aucgugcugc accuggagcc ccagaacgag       60

cuggaccccg uggaccugcu gugcuacgag cagcugagcg agagcgagga ggagaacgac      120

gaggccgacg gcgugagcca cgcccagcug cccgccagaa gagccgagcc ccagagacac      180

aagauccugu gcgugugcug caagugcgac ggcagaaucg agcugaccgu ggagagcagc      240

gccgaggacc ugagaacccu gcagcagcug uuccugagca cccugagcuu cgugugcccc      300

uggugcgcca ccaaccagug a                                                321


<210>  1286
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_45__CAA52574

<400>  1286
augcacggcc ccagagagac ccugcaggaa aucgugcucc aucuggagcc ucagaacgaa       60

cuugacccgg ucgaucugcu cugcuacgag cagcugagcg aauccgagga ggaaaaugac      120

gaggccgaug ggguuucuca cgcucagcuu cccgcccggc gcgcggaacc ucagagacau      180

aagauucugu gugugugcug uaaaugcgac ggacggaucg agcucacagu ggagagcucc      240

gcugaagauc ugcgcacgcu gcaacaacuc uuccugucua cccuuagcuu ugucuguccc      300

uggugcgcca caaaccagug a                                                321


<210>  1287
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_51__P26558

<400>  1287

Met Arg Gly Asn Val Pro Gln Leu Lys Asp Val Val Leu His Leu Thr 
1               5                   10                  15      


Pro Gln Thr Glu Ile Asp Leu Gln Cys Tyr Glu Gln Phe Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Val Asp Asn Met Arg Asp Gln Leu Pro Glu Arg 
        35                  40                  45              


Arg Ala Gly Gln Ala Thr Cys Tyr Arg Ile Glu Ala Pro Cys Cys Arg 
    50                  55                  60                  


Cys Ser Ser Val Val Gln Leu Ala Val Glu Ser Ser Gly Asp Thr Leu 
65                  70                  75                  80  


Arg Val Val Gln Gln Met Leu Met Gly Glu Leu Ser Leu Val Cys Pro 
                85                  90                  95      


Cys Cys Ala Asn Asn 
            100     


<210>  1288
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_51__M62877.1

<400>  1288
augcguggua auguaccaca auuaaaagau guaguauugc auuuaacacc acagacugaa       60

auugacuugc aaugcuacga gcaauuugac agcucagagg aggaggauga aguagauaau      120

augcgugacc agcuaccaga aagacgggcu ggacaggcua cguguuacag aauugaagcu      180

ccguguugca gguguucaag uguaguacaa cuggcagugg aaagcagugg agacacccuu      240

cgcguuguac agcagauguu aaugggcgaa cuaagccugg uuugcccgug uugugcgaac      300

aacuag                                                                 306


<210>  1289
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_51__M62877.1

<400>  1289
augcgcggca acgugcccca gcugaaggac gucgugcucc accugacccc gcagaccgag       60

aucgaccugc agugcuacga gcaguucgac agcuccgagg aggaggacga gguggacaac      120

augcgggacc agcuccccga gcgccgggcc gggcaggcca cgugcuaccg caucgaggcg      180

cccugcugcc ggugcagcuc cgucgugcag cuggccgugg agagcuccgg cgacacccug      240

cgcgucgugc agcagaugcu caugggggag cugagccugg ugugccccug cugcgccaac      300

aacuga                                                                 306


<210>  1290
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_51__M62877.1

<400>  1290
augcgcggca acguccccca gcucaaggac gucguccucc accucacccc ccagaccgag       60

aucgaccucc agugcuacga gcaguucgac uccuccgagg aggaggacga ggucgacaac      120

augcgcgacc agcuccccga gcgccgcgcc ggccaggcca ccugcuaccg caucgaggcc      180

cccugcugcc gcugcuccuc cgucguccag cucgccgucg aguccuccgg cgacacccuc      240

cgcgucgucc agcagaugcu caugggcgag cucucccucg ucugccccug cugcgccaac      300

aacuga                                                                 306


<210>  1291
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_51__M62877.1

<400>  1291
augagaggca acgugcccca gcugaaggac gucguucucc accuuacccc ucaaacagag       60

aucgaucugc agugcuacga acaguucgac agcuccgagg aagaggauga aguggacaau      120

augagggauc aguugccaga gcggcgcgcc gggcaagcua cuuguuaucg aauugaggca      180

ccgugcuguc guuguucuuc aguagugcag uuagccgucg aaaguagcgg agacacgcug      240

agagugguuc agcagaugcu aaugggugag cucucccugg ugugccccug cugugcgaac      300

aauuga                                                                 306


<210>  1292
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_51__M62877.1

<400>  1292
augagaggca acgugcccca gcugaaggac guggugcugc accugacccc ccagaccgag       60

aucgaccugc agugcuacga gcaguucgac agcagcgagg aggaggacga gguggacaac      120

augagagacc agcugcccga gagaagagcc ggccaggcca ccugcuacag aaucgaggcc      180

cccugcugca gaugcagcag cguggugcag cuggccgugg agagcagcgg cgacacccug      240

agaguggugc agcagaugcu gaugggcgag cugagccugg ugugccccug cugcgccaac      300

aacuga                                                                 306


<210>  1293
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_51__M62877.1

<400>  1293
augagaggca acgugcccca gcugaaggac gucguucucc accugacccc ucaaacagag       60

aucgaucuuc agugcuacga acaguucgac agcuccgagg aagaggauga aguggacaau      120

augcgggauc agcugccgga gcgcagagcc gggcaagcua cguguuaucg gauugaggcc      180

cccugcuguc gcugcucuag cgugguccag cucgcggugg aauccucugg agacacccug      240

agaguugugc agcagaugcu uaugggcgag cugagccucg ucuguccuug cugugcuaac      300

aauuga                                                                 306


<210>  1294
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_52__P36831

<400>  1294

Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly Gln Ala Glu 
        35                  40                  45              


Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp 
    50                  55                  60                  


Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Gln Gln Met Leu Leu Gly Thr Leu Gln Val Val Cys Pro Gly Cys 
                85                  90                  95      


Ala Arg Leu 
            


<210>  1295
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_52__CAA52586

<400>  1295
augcguggag acaaagcaac uauaaaagau uauauauuag aucugcaacc ugaaacaacu       60

gaccuacacu gcuaugagca auuaggugac agcucagaug aggaggauac agauggugug      120

gaccggccag auggacaagc agaacaagcc acaagcaauu acuacauugu gacauauugu      180

cacaguugug auagcacacu acggcuaugc auucauagca cugcgacgga ccuucguacu      240

cuacagcaaa ugcuguuggg cacauuacaa guugugugcc ccggcugugc acggcuauaa      300


<210>  1296
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_52__CAA52586

<400>  1296
augcgcggcg acaaggccac caucaaggac uacauccugg accuccagcc cgagaccacg       60

gaccugcacu gcuacgagca gcugggggac agcuccgacg aggaggacac cgacggcgug      120

gaccggccgg acgggcaggc cgagcaggcg accagcaacu acuacaucgu caccuacugc      180

cacuccugcg acagcacgcu ccgccugugc auccacucca ccgccaccga ccugcggacc      240

cuccagcaga ugcugcuggg cacgcuccag guggugugcc ccgggugcgc ccgccuguga      300


<210>  1297
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_52__CAA52586

<400>  1297
augcgcggcg acaaggccac caucaaggac uacauccucg accuccagcc cgagaccacc       60

gaccuccacu gcuacgagca gcucggcgac uccuccgacg aggaggacac cgacggcguc      120

gaccgccccg acggccaggc cgagcaggcc accuccaacu acuacaucgu caccuacugc      180

cacuccugcg acuccacccu ccgccucugc auccacucca ccgccaccga ccuccgcacc      240

cuccagcaga ugcuccucgg cacccuccag gucgucugcc ccggcugcgc ccgccucuga      300


<210>  1298
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_52__CAA52586

<400>  1298
augagaggcg acaaggccac caucaaagau uacauucugg accuccagcc cgagacaacu       60

gaucuucacu gcuaugaaca acugggggac agcuccgaug aggaagacac ggauggagug      120

gacaggccug auggucaggc ugagcaggca accucuaacu acuauauagu cacauacugu      180

cauucaugcg acaguacuuu gcgguuaugu auccacagca ccgccacaga ucugcgcacc      240

cuacagcaaa ugcuccuggg cacucuucag guugugugcc cagggugugc gcgacuguga      300


<210>  1299
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_52__CAA52586

<400>  1299
augagaggcg acaaggccac caucaaggac uacauccugg accugcagcc cgagaccacc       60

gaccugcacu gcuacgagca gcugggcgac agcagcgacg aggaggacac cgacggcgug      120

gacagacccg acggccaggc cgagcaggcc accagcaacu acuacaucgu gaccuacugc      180

cacagcugcg acagcacccu gagacugugc auccacagca ccgccaccga ccugagaacc      240

cugcagcaga ugcugcuggg cacccugcag guggugugcc ccggcugcgc cagacuguga      300


<210>  1300
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_52__CAA52586

<400>  1300
augagaggcg acaaggccac caucaaagau uacauucugg accuccagcc cgagacaacg       60

gaucugcacu gcuaugaaca acuuggggac agcuccgaug aggaagacac cgauggagug      120

gaccggccug auggccaggc ugagcaggcc acaucuaacu acuauaucgu caccuacugu      180

cauagcugcg acuccacacu gcgccucugu auucacucua ccgcgacaga ucugagaacc      240

cuucagcaaa ugcugcucgg gacgcugcag guugugugcc cgggaugugc ucggcuguga      300


<210>  1301
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_56__P36833

<400>  1301

Met His Gly Lys Val Pro Thr Leu Gln Asp Val Val Leu Glu Leu Thr 
1               5                   10                  15      


Pro Gln Thr Glu Ile Asp Leu Gln Cys Asn Glu Gln Leu Asp Ser Ser 
            20                  25                  30          


Glu Asp Glu Asp Glu Asp Glu Val Asp His Leu Gln Glu Arg Pro Gln 
        35                  40                  45              


Gln Ala Arg Gln Ala Lys Gln His Thr Cys Tyr Leu Ile His Val Pro 
    50                  55                  60                  


Cys Cys Glu Cys Lys Phe Val Val Gln Leu Asp Ile Gln Ser Thr Lys 
65                  70                  75                  80  


Glu Asp Leu Arg Val Val Gln Gln Leu Leu Met Gly Ala Leu Thr Val 
                85                  90                  95      


Thr Cys Pro Leu Cys Ala Ser Ser Asn 
            100                 105 


<210>  1302
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_56__CAA52597

<400>  1302
augcauggua aaguaccaac gcugcaagac guuguauuag aacuaacacc ucaaacagaa       60

auugaccuac agugcaauga gcaauuggac agcucagagg augaggauga ggaugaagua      120

gaccauuugc aggagcggcc acagcaagcu agacaagcua aacaacauac guguuaccua      180

auacacguac cuuguuguga guguaaguuu guggugcagu uggacauuca gaguaccaaa      240

gaggaccugc guguuguaca acagcugcuu augggugcgu uaacaguaac gugcccacuc      300

ugcgcaucaa guaacuaa                                                    318


<210>  1303
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_56__CAA52597

<400>  1303
augcacggca aggugcccac ccugcaggac gucgugcucg agcugacccc gcagacggag       60

aucgaccugc agugcaacga gcagcucgac agcuccgagg acgaggacga ggacgaggug      120

gaccaccucc aggagcgccc ccagcaggcc cggcaggcca agcagcacac gugcuaccug      180

auccacgucc ccugcugcga gugcaaguuc guggugcagc uggacaucca gagcaccaag      240

gaggaccugc gcgucgugca gcagcugcuc augggggcgc ugaccgugac cugcccccug      300

ugcgccucca gcaacuga                                                    318


<210>  1304
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_56__CAA52597

<400>  1304
augcacggca agguccccac ccuccaggac gucguccucg agcucacccc ccagaccgag       60

aucgaccucc agugcaacga gcagcucgac uccuccgagg acgaggacga ggacgagguc      120

gaccaccucc aggagcgccc ccagcaggcc cgccaggcca agcagcacac cugcuaccuc      180

auccacgucc ccugcugcga gugcaaguuc gucguccagc ucgacaucca guccaccaag      240

gaggaccucc gcgucgucca gcagcuccuc augggcgccc ucaccgucac cugcccccuc      300

ugcgccuccu ccaacuga                                                    318


<210>  1305
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_56__CAA52597

<400>  1305
augcacggca aggugcccac ccugcaggac gucguucucg agcuuacacc ucaaacugaa       60

aucgaucugc agugcaacga gcaguuggac agcuccgaag augaggacga agaugaggug      120

gaccauuuac aggagagacc acaacaggcc aggcaggcua aacagcacac guguuaccug      180

auucauguac cgugcuguga augcaaguuc gugguccaac uagauauaca gucuaccaaa      240

gaggaccucc gggugguuca gcagcugcuu augggggcac ugacagugac uugucccuug      300

ugcgccucaa guaauuga                                                    318


<210>  1306
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_56__CAA52597

<400>  1306
augcacggca aggugcccac ccugcaggac guggugcugg agcugacccc ccagaccgag       60

aucgaccugc agugcaacga gcagcuggac agcagcgagg acgaggacga ggacgaggug      120

gaccaccugc aggagagacc ccagcaggcc agacaggcca agcagcacac cugcuaccug      180

auccacgugc ccugcugcga gugcaaguuc guggugcagc uggacaucca gagcaccaag      240

gaggaccuga gaguggugca gcagcugcug augggcgccc ugaccgugac cugcccccug      300

ugcgccagca gcaacuga                                                    318


<210>  1307
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_56__CAA52597

<400>  1307
augcacggca aggugcccac ccugcaggac gucguucucg agcugacacc ucaaacggaa       60

aucgaucuuc agugcaacga gcagcuggac agcuccgaag augaggacga agaugaggug      120

gaccaucucc aggagagacc gcaacaggcc cggcaggcua aacagcacac cuguuaccug      180

auucaugugc ccugcuguga augcaaguuc gucgugcaac uugauaucca gucuacaaaa      240

gaggaccugc gcguugugca gcagcuccug augggggccc ugaccgucac auguccucuc      300

ugcgcgagcu ccaauuga                                                    318


<210>  1308
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_58__Q9QCZ1

<400>  1308

Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Ile Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro 
        35                  40                  45              


Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr 
    50                  55                  60                  


Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu 
65                  70                  75                  80  


Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala 
                85                  90                  95      


Gln Gln 
        


<210>  1309
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_58__AAF13691

<400>  1309
augagaggaa acaacccaac gcuaagagaa uauauuuuag auuuacaucc ugaaccaacu       60

gaccuauucu gcuaugagca auuaugugac agcucagacg aggaugaaau aggcuuggac      120

aggccagaug gacaagcaca accggccaca gcuaauuacu acauuguaac guguuguuac      180

acuugugaca ccacgguucg uuuguguauc aacaguacaa caaccgacgu acgaacccua      240

cagcagcugc uuaugggcac auguaccauu gugugcccua gcugugcaca gcaauaa         297


<210>  1310
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_58__AAF13691

<400>  1310
augcgcggca acaaccccac ccugcgggag uacauccucg accugcaccc ggagcccacc       60

gaccuguucu gcuacgagca gcucugcgac agcuccgacg aggacgagau cgggcuggac      120

cgccccgacg gccaggccca gcccgccacg gcgaacuacu acaucgugac cugcugcuac      180

acgugcgaca ccaccguccg gcugugcauc aacagcacca ccaccgacgu gcgcacgcuc      240

cagcagcugc ugauggggac cugcaccauc gugugcccgu ccugcgccca gcaguga         297


<210>  1311
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_58__AAF13691

<400>  1311
augcgcggca acaaccccac ccuccgcgag uacauccucg accuccaccc cgagcccacc       60

gaccucuucu gcuacgagca gcucugcgac uccuccgacg aggacgagau cggccucgac      120

cgccccgacg gccaggccca gcccgccacc gccaacuacu acaucgucac cugcugcuac      180

accugcgaca ccaccguccg ccucugcauc aacuccacca ccaccgacgu ccgcacccuc      240

cagcagcucc ucaugggcac cugcaccauc gucugccccu ccugcgccca gcaguga         297


<210>  1312
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_58__AAF13691

<400>  1312
augagaggca acaaucccac ccugagggag uacauccucg accuucaccc ugaaccaaca       60

gaucuguucu gcuacgagca guugugugac agcuccgaug aagacgagau uggguuagau      120

cggccggacg gacaagccca gcccgcuacu gcaaacuacu auauagugac gugcuguuau      180

accugcgaua caacuguccg ccuguguauc aauucuacca caaccgacgu ucgaacucua      240

cagcagcucc ugauggguac augcaccauu guguguccuu caugcgccca acaguga         297


<210>  1313
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_58__AAF13691

<400>  1313
augagaggca acaaccccac ccugagagag uacauccugg accugcaccc cgagcccacc       60

gaccuguucu gcuacgagca gcugugcgac agcagcgacg aggacgagau cggccuggac      120

agacccgacg gccaggccca gcccgccacc gccaacuacu acaucgugac cugcugcuac      180

accugcgaca ccaccgugag acugugcauc aacagcacca ccaccgacgu gagaacccug      240

cagcagcugc ugaugggcac cugcaccauc gugugcccca gcugcgccca gcaguga         297


<210>  1314
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_58__AAF13691

<400>  1314
augagaggca acaaucccac ccugcgggag uacauccucg accugcaccc ugaaccgaca       60

gaucuuuucu gcuaugagca gcugugugac agcuccgaug aagacgagau uggccucgau      120

cgccccgacg gacaagccca gccugcuacg gccaacuacu auaucgugac cugcuguuac      180

acaugcgaua ccacagucag acuguguauu aauucuacca caaccgacgu ucggacgcuu      240

cagcagcugc ucauggggac cugcacaauc guguguccca gcugcgcgca acaguga         297


<210>  1315
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_59__Q81965

<400>  1315

Met His Gly Pro Lys Ala Thr Leu Cys Asp Ile Val Leu Asp Leu Glu 
1               5                   10                  15      


Pro Gln Asn Tyr Glu Glu Val Asp Leu Val Cys Tyr Glu Gln Leu Pro 
            20                  25                  30          


Asp Ser Asp Ser Glu Asn Glu Lys Asp Glu Pro Asp Gly Val Asn His 
        35                  40                  45              


Pro Leu Leu Leu Ala Arg Arg Ala Glu Pro Gln Arg His Asn Ile Val 
    50                  55                  60                  


Cys Val Cys Cys Lys Cys Asn Asn Gln Leu Gln Leu Val Val Glu Thr 
65                  70                  75                  80  


Ser Gln Asp Gly Leu Arg Ala Leu Gln Gln Leu Phe Met Asp Thr Leu 
                85                  90                  95      


Ser Phe Val Cys Pro Leu Cys Ala Ala Asn Gln 
            100                 105         


<210>  1316
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_59__ACL12335

<400>  1316
augcauggac caaaagcaac acuuugugac auuguuuuag auuuggaacc acaaaauuau       60

gaggaaguug accuugugug cuacgagcaa uuaccugacu ccgacuccga gaaugaaaaa      120

gaugaaccag auggaguuaa ucauccuuug cuacuagcua gacgagcuga accacagcgu      180

cacaacauug ugugugugug uuguaagugu aauaaucaac uucagcuagu aguagaaacc      240

ucgcaagacg gauugcgagc cuuacagcag cuguuuaugg acacacuauc cuuugugugu      300

ccuuugugug cagcaaacca guaa                                             324


<210>  1317
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_59__ACL12335

<400>  1317
augcacggcc ccaaggccac ccugugcgac aucgugcucg accuggagcc gcagaacuac       60

gaggaggucg accuggugug cuacgagcag cuccccgaca gcgacuccga gaacgagaag      120

gacgagcccg acggggugaa ccacccccug cugcucgccc gccgggcgga gccgcagcgc      180

cacaacaucg ucugcgugug cugcaagugc aacaaccagc ugcagcuggu ggucgagacc      240

agccaggacg gccuccgggc ccugcagcag cuguucaugg acacgcucuc cuucgugugc      300

ccccugugcg ccgccaacca guga                                             324


<210>  1318
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_59__ACL12335

<400>  1318
augcacggcc ccaaggccac ccucugcgac aucguccucg accucgagcc ccagaacuac       60

gaggaggucg accucgucug cuacgagcag cuccccgacu ccgacuccga gaacgagaag      120

gacgagcccg acggcgucaa ccacccccuc cuccucgccc gccgcgccga gccccagcgc      180

cacaacaucg ucugcgucug cugcaagugc aacaaccagc uccagcucgu cgucgagacc      240

ucccaggacg gccuccgcgc ccuccagcag cucuucaugg acacccucuc cuucgucugc      300

ccccucugcg ccgccaacca guga                                             324


<210>  1319
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_59__ACL12335

<400>  1319
augcacggcc ccaaggccac ccugugcgac aucgugcucg aucuugagcc ucagaacuac       60

gaagaggucg accugguuug uuaugaacaa uugccagaua gcgacuccga gaaugaaaaa      120

gaugagccgg acggggugaa ccaucccuua cugcuagcua gaagggcaga gccucagcgg      180

cacaauauug uaugcgugug uugcaagugu aacaaucagc uccagcuggu cguggaaaca      240

ucucaagaug gacuucgcgc ccugcagcag uuguucaugg acacucucuc auuuguuugc      300

ccacugugug cggcuaacca guga                                             324


<210>  1320
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_59__ACL12335

<400>  1320
augcacggcc ccaaggccac ccugugcgac aucgugcugg accuggagcc ccagaacuac       60

gaggaggugg accuggugug cuacgagcag cugcccgaca gcgacagcga gaacgagaag      120

gacgagcccg acggcgugaa ccacccccug cugcuggcca gaagagccga gccccagaga      180

cacaacaucg ugugcgugug cugcaagugc aacaaccagc ugcagcuggu gguggagacc      240

agccaggacg gccugagagc ccugcagcag cuguucaugg acacccugag cuucgugugc      300

ccccugugcg ccgccaacca guga                                             324


<210>  1321
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_59__ACL12335

<400>  1321
augcacggcc ccaaggccac ccugugcgac aucgugcucg aucuggagcc ucagaacuac       60

gaagaggucg accuuguuug uuaugaacag cugccggaua gcgacuccga gaaugaaaaa      120

gaugagcccg acggggugaa ccauccucuc cugcuugcua gacgggccga gccccagcgc      180

cacaauauug ugugcgucug uugcaagugu aacaaucagc ugcagcucgu gguugaaaca      240

ucucaagaug gacugagagc gcugcagcaa cucuucaugg acacgcugag cuuugugugc      300

ccucuuugug cugccaacca guga                                             324


<210>  1322
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_66__Q80956

<400>  1322

Met His Gly Lys Val Pro Thr Leu Gln Glu Val Ile Leu Glu Leu Ala 
1               5                   10                  15      


Pro Gln Thr Glu Ile Asp Leu Gln Cys Asn Glu Gln Leu Asp Ser Ser 
            20                  25                  30          


Glu Asp Glu Asp Glu Asp Glu Ile Asp His Leu Leu Glu Arg Pro Gln 
        35                  40                  45              


Gln Ala Arg Gln Ala Glu Gln His Lys Cys Tyr Leu Ile His Val Pro 
    50                  55                  60                  


Cys Cys Lys Cys Glu Leu Val Val Gln Leu Asp Ile Gln Ser Thr Lys 
65                  70                  75                  80  


Glu Glu Leu Arg Val Val Gln Gln Leu Leu Met Gly Ala Leu Thr Val 
                85                  90                  95      


Thr Cys Pro Leu Cys Ala Ser Ser Lys 
            100                 105 


<210>  1323
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  E7__Human_papillomavirus_type_66__AAA79500

<400>  1323
augcauggua aaguaccaac guugcaagag guuauauuag aacuugcacc gcaaacggaa       60

auugaccuac aaugcaauga gcaauuggac agcucagagg augaggauga ggaugaaaua      120

gaccauuugc uggagcggcc acagcaagcu agacaagcug aacaacauaa guguuaccua      180

auucacguac cuuguuguaa gugugaguug guggugcagu uggacauuca gaguaccaaa      240

gaggagcuac gugugguaca acagcugcuu augggugcgu uaacaguaac gugcccacuc      300

ugcgcaucau cuaaauaa                                                    318


<210>  1324
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       E7__Human_papillomavirus_type_66__AAA79500

<400>  1324
augcacggca agguccccac ccugcaggag gucauccucg agcuggcccc gcagaccgag       60

aucgaccugc agugcaacga gcagcucgac agcuccgagg acgaggacga ggacgagauc      120

gaccaccucc uggagcgccc ccagcaggcc cggcaggcgg agcagcacaa gugcuaccug      180

auccacgugc ccugcugcaa gugcgagcug gugguccagc uggacaucca gagcacgaag      240

gaggagcucc gcguggugca gcagcugcug augggggccc ucaccgugac cugcccccug      300

ugcgccucca gcaaguga                                                    318


<210>  1325
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       E7__Human_papillomavirus_type_66__AAA79500

<400>  1325
augcacggca agguccccac ccuccaggag gucauccucg agcucgcccc ccagaccgag       60

aucgaccucc agugcaacga gcagcucgac uccuccgagg acgaggacga ggacgagauc      120

gaccaccucc ucgagcgccc ccagcaggcc cgccaggccg agcagcacaa gugcuaccuc      180

auccacgucc ccugcugcaa gugcgagcuc gucguccagc ucgacaucca guccaccaag      240

gaggagcucc gcgucgucca gcagcuccuc augggcgccc ucaccgucac cugcccccuc      300

ugcgccuccu ccaaguga                                                    318


<210>  1326
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       E7__Human_papillomavirus_type_66__AAA79500

<400>  1326
augcacggca aggugcccac ccugcaggag gucauccucg aacuugcccc ucaaacagag       60

auugaccugc agugcaacga acaguuggau agcuccgagg acgaagauga ggacgagaua      120

gaucauuuac uggaaagacc acagcaagcu aggcaggcag agcagcacaa auguuaccua      180

auccauguuc cgugcuguaa gugcgaacuc gugguacagc uggacauuca aucuacuaaa      240

gaggagcuuc ggguggucca gcagcuguug augggggccc ucacggugac cuguccccug      300

ugcgcgucaa guaaguga                                                    318


<210>  1327
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       E7__Human_papillomavirus_type_66__AAA79500

<400>  1327
augcacggca aggugcccac ccugcaggag gugauccugg agcuggcccc ccagaccgag       60

aucgaccugc agugcaacga gcagcuggac agcagcgagg acgaggacga ggacgagauc      120

gaccaccugc uggagagacc ccagcaggcc agacaggccg agcagcacaa gugcuaccug      180

auccacgugc ccugcugcaa gugcgagcug guggugcagc uggacaucca gagcaccaag      240

gaggagcuga gaguggugca gcagcugcug augggcgccc ugaccgugac cugcccccug      300

ugcgccagca gcaaguga                                                    318


<210>  1328
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       E7__Human_papillomavirus_type_66__AAA79500

<400>  1328
augcacggca aggugcccac ccugcaggag gucauccucg aacuggcccc ucaaacagag       60

auugaccuuc agugcaacga acagcuggau agcuccgagg acgaagauga ggacgagauc      120

gaucaucucc uggaaagacc gcagcaagcu cggcaggccg agcagcacaa auguuaccuu      180

auucauguuc ccugcuguaa gugcgaacug guggugcagc ucgacaucca aucuacgaaa      240

gaggagcugc gcgucgugca gcagcugcuc augggggcgc ugaccguuac auguccucuu      300

ugcgcuagcu ccaaguga                                                    318


<210>  1329
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EF1A2__Homo_sapiens__Q05639

<400>  1329

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Thr Lys Tyr Tyr Ile Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Ala Tyr Ser Glu Lys Arg Tyr Asp Glu Ile Val Lys Glu Val Ser Ala 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Ala Thr Val Pro Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro Ser Pro Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Glu Arg Lys Glu Gly Asn Ala Ser 
    210                 215                 220                 


Gly Val Ser Leu Leu Glu Ala Leu Asp Thr Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Ile Leu 
            260                 265                 270         


Arg Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Ile Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Ile 
305                 310                 315                 320 


Arg Arg Gly Asn Val Cys Gly Asp Ser Lys Ser Asp Pro Pro Gln Glu 
                325                 330                 335     


Ala Ala Gln Phe Thr Ser Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ser Pro Val Ile Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Asn Pro Lys Ser Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Glu Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Gln Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Asn Val Glu Lys Lys Ser Gly Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Gly Lys 
    450                 455                 460             


<210>  1330
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EF1A2__Homo_sapiens__AAF80488

<400>  1330
augggcaagg agaagaccca caucaacauc guggucaucg gccacgugga cuccggaaag       60

uccaccacca cgggccaccu caucuacaaa ugcggaggua uugacaaaag gaccauugag      120

aaguucgaga aggaggcggc ugagaugggg aagggauccu ucaaguaugc cugggugcug      180

gacaagcuga aggcggagcg ugagcgcggc aucaccaucg acaucucccu cuggaaguuc      240

gagaccacca aguacuacau caccaucauc gaugcccccg gccaccgcga cuucaucaag      300

aacaugauca cggguacauc ccaggcggac ugcgcagugc ugaucguggc ggcgggcgug      360

ggcgaguucg aggcgggcau cuccaagaau gggcagacgc gggagcaugc ccugcuggcc      420

uacacgcugg gugugaagca gcucaucgug ggcgugaaca aaauggacuc cacagagccg      480

gccuacagcg agaagcgcua cgacgagauc gucaaggaag ucagcgccua caucaagaag      540

aucggcuaca acccggccac cgugcccuuu gugcccaucu ccggcuggca cggcgacaac      600

augcuggagc ccucccccaa caugccgugg uucaagggcu ggaaggugga gcguaaggag      660

ggcaacgcaa gcggcguguc ccugcuggag gcccuggaca ccauccugcc ccccacgcgc      720

cccacggaca agccccugcg ccugccgcug caggacgugu acaagauugg cggcauuggc      780

acggugcccg ugggccgggu ggagaccggc auccugcggc cgggcauggu ggugaccuuu      840

gcgccaguga acaucaccac ugaggugaag ucaguggaga ugcaccacga ggcucugagc      900

gaagcucugc ccggcgacaa cgucggcuuc aaugugaaga acgugucggu gaaggacauc      960

cggcggggca acgugugugg ggacagcaag ucugacccgc cgcaggaggc ugcucaguuc     1020

accucccagg ucaucauccu gaaccacccg gggcagauua gcgccggcua cuccccgguc     1080

aucgacugcc acacagccca caucgccugc aaguuugcgg agcugaagga gaagauugac     1140

cggcgcucug gcaagaagcu ggaggacaac cccaaguccc ugaagucugg agacgcggcc     1200

aucguggaga uggugccggg aaagcccaug uguguggaga gcuucuccca guacccgccu     1260

cucggccgcu ucgccgugcg cgacaugagg cagacggugg ccguaggcgu caucaagaac     1320

guggaaaaga agagcggcgg cgccggcaag gucaccaagu cggcgcagaa ggcgcagaag     1380

gcgggcaagu ga                                                         1392


<210>  1331
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EF1A2__Homo_sapiens__AAF80488

<400>  1331
augggcaagg agaagacgca caucaacauc guggucaucg ggcacgugga cagcggcaag       60

uccaccacga ccgggcaccu gaucuacaag ugcggcggga ucgacaagcg caccaucgag      120

aaguucgaga aggaggccgc cgagaugggc aagggcagcu ucaaguacgc gugggugcuc      180

gacaagcuga aggccgagcg ggagcgcggg aucaccaucg acaucucccu guggaaguuc      240

gagacgacca aguacuacau caccaucauc gacgcccccg gccaccggga cuucaucaag      300

aacaugauca ccgggacgag ccaggccgac ugcgccgucc ucaucguggc ggccggcgug      360

ggggaguucg aggccggcau cuccaagaac ggccagaccc gcgagcacgc ccugcuggcg      420

uacacccucg gggucaagca gcugaucgug ggcgugaaca agauggacag caccgagccg      480

gccuacuccg agaagcggua cgacgagauc gucaaggagg ugagcgccua caucaagaag      540

aucggguaca accccgccac ggugcccuuc guccccaucu ccggcuggca cggcgacaac      600

augcuggagc cgagccccaa caugcccugg uucaaggggu ggaaggugga gcgcaaggag      660

ggcaacgccu ccggggugag ccuccuggag gcgcuggaca ccauccugcc cccgacccgg      720

cccaccgaca agccccugcg ccugccccuc caggacgucu acaagaucgg cgggaucggc      780

acggugccgg ugggccgggu cgagaccggg auccugcgcc ccggcauggu ggugaccuuc      840

gcccccguca acaucaccac ggaggugaag uccguggaga ugcaccacga ggcccugagc      900

gaggcccucc ccggggacaa cgucggcuuc aacgugaaga acgucuccgu gaaggacauc      960

cggcgcggga acgugugcgg cgacagcaag uccgacccgc cccaggaggc cgcgcaguuc     1020

accagccagg ucaucauccu gaaccacccc ggccagaucu ccgccgggua cagccccgug     1080

aucgacugcc acaccgccca caucgccugc aaguucgccg agcugaagga gaagaucgac     1140

cggcgcagcg gcaagaagcu cgaggacaac ccgaaguccc ucaagagcgg ggacgcggcc     1200

aucguggaga ugguccccgg caagcccaug ugcguggagu ccuucagcca guacccgccc     1260

cuggggcggu ucgccgugcg cgacaugcgg cagaccgucg ccgugggcgu gaucaagaac     1320

gucgagaaga aguccggcgg ggccggcaag gugaccaaga gcgcgcagaa ggcccagaag     1380

gccgggaagu ga                                                         1392


<210>  1332
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EF1A2__Homo_sapiens__AAF80488

<400>  1332
augggcaagg agaagaccca caucaacauc gucgucaucg gccacgucga cuccggcaag       60

uccaccacca ccggccaccu caucuacaag ugcggcggca ucgacaagcg caccaucgag      120

aaguucgaga aggaggccgc cgagaugggc aagggcuccu ucaaguacgc cuggguccuc      180

gacaagcuca aggccgagcg cgagcgcggc aucaccaucg acaucucccu cuggaaguuc      240

gagaccacca aguacuacau caccaucauc gacgcccccg gccaccgcga cuucaucaag      300

aacaugauca ccggcaccuc ccaggccgac ugcgccgucc ucaucgucgc cgccggcguc      360

ggcgaguucg aggccggcau cuccaagaac ggccagaccc gcgagcacgc ccuccucgcc      420

uacacccucg gcgucaagca gcucaucguc ggcgucaaca agauggacuc caccgagccc      480

gccuacuccg agaagcgcua cgacgagauc gucaaggagg ucuccgccua caucaagaag      540

aucggcuaca accccgccac cguccccuuc guccccaucu ccggcuggca cggcgacaac      600

augcucgagc ccucccccaa caugcccugg uucaagggcu ggaaggucga gcgcaaggag      660

ggcaacgccu ccggcgucuc ccuccucgag gcccucgaca ccauccuccc ccccacccgc      720

cccaccgaca agccccuccg ccucccccuc caggacgucu acaagaucgg cggcaucggc      780

accguccccg ucggccgcgu cgagaccggc auccuccgcc ccggcauggu cgucaccuuc      840

gcccccguca acaucaccac cgaggucaag uccgucgaga ugcaccacga ggcccucucc      900

gaggcccucc ccggcgacaa cgucggcuuc aacgucaaga acgucuccgu caaggacauc      960

cgccgcggca acgucugcgg cgacuccaag uccgaccccc cccaggaggc cgcccaguuc     1020

accucccagg ucaucauccu caaccacccc ggccagaucu ccgccggcua cucccccguc     1080

aucgacugcc acaccgccca caucgccugc aaguucgccg agcucaagga gaagaucgac     1140

cgccgcuccg gcaagaagcu cgaggacaac cccaaguccc ucaaguccgg cgacgccgcc     1200

aucgucgaga ugguccccgg caagcccaug ugcgucgagu ccuucuccca guaccccccc     1260

cucggccgcu ucgccguccg cgacaugcgc cagaccgucg ccgucggcgu caucaagaac     1320

gucgagaaga aguccggcgg cgccggcaag gucaccaagu ccgcccagaa ggcccagaag     1380

gccggcaagu ga                                                         1392


<210>  1333
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EF1A2__Homo_sapiens__AAF80488

<400>  1333
augggcaagg agaaaaccca caucaacauu guggucauag ggcauguuga cagcggaaag       60

uccacaacua cgggucaccu gaucuacaaa ugcggcggga uugauaagag aaccaucgaa      120

aaauucgaga aggaagccgc ugagauggga aagggcucuu uuaaauaugc augggugcuc      180

gacaaacuua aagccgaaag ggagcggggu auuacaaucg auauaucacu guggaaguuc      240

gagacuacca aauacuauau cacaauuauc gacgcgcccg ggcaucgcga uuuuauuaag      300

aauaugauca ccggaacaag ucaggcugac ugugccguau ugauaguggc agccggcguc      360

ggcgaguucg aagcugggau uagcaagaac ggacaaacuc gagaacacgc auuacuggcc      420

uacacccuag gugugaaaca gcucaucguu ggcgugaaua agauggauuc cacggagccu      480

gcuuauucug agaaacguua cgacgaaauu gucaaggagg ugucggccua uaucaaaaag      540

aucggguaca acccagcgac uguaccguuu guucccauuu caggauggca uggcgauaau      600

augcuggaac cuagcccaaa caugcccugg uucaaagguu ggaaggugga gagaaaggaa      660

gggaaugcaa guggagucuc ccuucuggag gccuuggaca ccauacuccc uccaacaagg      720

cccacugaua aaccucugcg gcugccacuc caggacgugu acaagaucgg cggcauuggg      780

accgugccgg ucggacgcgu ugagacaggu aucuuaagac ccggcauggu gguaaccuuu      840

gcuccuguga acauaacgac ugaagucaaa ucuguggaga ugcaccacga agcccugagc      900

gaggcacuuc caggggauaa uguuggauuc aacgugaaga augucuccgu gaaagacauu      960

aggcggggca acguaugcgg ugacucaaag agugaucccc cucaggaagc ugcccaauuu     1020

acaagccagg uuaucaucuu gaaucaucca gggcagauuu cugcgggcua uucccccgug     1080

aucgacuguc acaccgccca uauugcaugc aaguucgcug agcugaaaga gaagauagau     1140

cgccgaucag gaaagaagcu agaagacaac ccgaaaagcc ucaagagugg cgaugccgcu     1200

aucgucgaga uggugccugg gaagcccaug ugugucgaau cuuuuuccca guacccaccu     1260

cugggaagau ucgccgugag ggacaugcgg caaacuguug cagugggugu aauuaaaaau     1320

gucgagaaga aaagcggcgg ggccggaaag gugacaaaau cggcucagaa ggcgcagaag     1380

gcaggcaaau ga                                                         1392


<210>  1334
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EF1A2__Homo_sapiens__AAF80488

<400>  1334
augggcaagg agaagaccca caucaacauc guggugaucg gccacgugga cagcggcaag       60

agcaccacca ccggccaccu gaucuacaag ugcggcggca ucgacaagag aaccaucgag      120

aaguucgaga aggaggccgc cgagaugggc aagggcagcu ucaaguacgc cugggugcug      180

gacaagcuga aggccgagag agagagaggc aucaccaucg acaucagccu guggaaguuc      240

gagaccacca aguacuacau caccaucauc gacgcccccg gccacagaga cuucaucaag      300

aacaugauca ccggcaccag ccaggccgac ugcgccgugc ugaucguggc cgccggcgug      360

ggcgaguucg aggccggcau cagcaagaac ggccagacca gagagcacgc ccugcuggcc      420

uacacccugg gcgugaagca gcugaucgug ggcgugaaca agauggacag caccgagccc      480

gccuacagcg agaagagaua cgacgagauc gugaaggagg ugagcgccua caucaagaag      540

aucggcuaca accccgccac cgugcccuuc gugcccauca gcggcuggca cggcgacaac      600

augcuggagc ccagccccaa caugcccugg uucaagggcu ggaaggugga gagaaaggag      660

ggcaacgcca gcggcgugag ccugcuggag gcccuggaca ccauccugcc ccccaccaga      720

cccaccgaca agccccugag acugccccug caggacgugu acaagaucgg cggcaucggc      780

accgugcccg ugggcagagu ggagaccggc auccugagac ccggcauggu ggugaccuuc      840

gcccccguga acaucaccac cgaggugaag agcguggaga ugcaccacga ggcccugagc      900

gaggcccugc ccggcgacaa cgugggcuuc aacgugaaga acgugagcgu gaaggacauc      960

agaagaggca acgugugcgg cgacagcaag agcgaccccc cccaggaggc cgcccaguuc     1020

accagccagg ugaucauccu gaaccacccc ggccagauca gcgccggcua cagccccgug     1080

aucgacugcc acaccgccca caucgccugc aaguucgccg agcugaagga gaagaucgac     1140

agaagaagcg gcaagaagcu ggaggacaac cccaagagcc ugaagagcgg cgacgccgcc     1200

aucguggaga uggugcccgg caagcccaug ugcguggaga gcuucagcca guaccccccc     1260

cugggcagau ucgccgugag agacaugaga cagaccgugg ccgugggcgu gaucaagaac     1320

guggagaaga agagcggcgg cgccggcaag gugaccaaga gcgcccagaa ggcccagaag     1380

gccggcaagu ga                                                         1392


<210>  1335
<211>  1392
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EF1A2__Homo_sapiens__AAF80488

<400>  1335
augggcaagg agaaaaccca caucaacauu guggucaucg ggcauguuga cagcggaaag       60

uccacaacga ccggccaccu gauuuacaaa ugcgggggaa ucgauaagag aacaauugaa      120

aaauucgaga aggaagccgc ugagaugggc aaggggucuu uuaaauaugc cugggugcuc      180

gacaagcuga aagcggaacg ggagcgcgga aucaccaucg auauuagccu uuggaaguuc      240

gagacaacca aauacuauau cacaauuauc gacgcucccg gccauagaga uuuuauuaag      300

aauaugauca ccggcacguc ccaggccgac ugugccgugc ugauugucgc ugccggggug      360

ggagaguucg aagcuggcau cucuaagaac gggcaaaccc gggaacacgc ccuccuggcg      420

uacacacuug gaguuaaaca gcugaucgug ggcgucaaua agauggauag caccgagccu      480

gccuauuccg agaaacgcua cgacgaaauu gugaaggagg uuucugcuua uaucaaaaag      540

auuggguaca acccggccac agugcccuuu gucccuauca gcggauggca uggcgauaau      600

augcucgaac ccuccccuaa caugcccugg uucaaaggcu ggaaggugga gagaaaggaa      660

gggaaugcua gcggaguguc ucugcuggag gcccucgaca ccauucugcc uccgacgcgg      720

cccacagaua aaccucuucg ccugccccuc caggacgucu acaagaucgg cgggaucgga      780

accguuccug ugggcagagu ggagacaggg auucugcggc ccggaauggu cgugaccuuu      840

gcgccgguua acaucaccac agaagugaaa uccgucgaga ugcaccacga agcccuuagc      900

gaggcucugc cuggcgauaa ugugggcuuc aacguuaaga augugucugu caaagacauu      960

cgcagaggga acgugugcgg agacuccaag agcgaucccc cucaggaagc cgcucaauuu     1020

acgucucagg ucaucauucu caaucauccc ggccagaucu ccgccgggua uagccccgug     1080

aucgacuguc acaccgccca uauugcuugc aaguucgcgg agcugaaaga gaagaucgau     1140

cggcgcuccg gcaaaaagcu ggaagacaac ccuaaaucuc ucaagagcgg agaugccgcu     1200

auuguugaga uggugccggg gaagcccaug ugugucgaau ccuuuagcca guacccuccc     1260

cugggcagau ucgccgugcg ggacaugcgc caaacaguug ccgugggagu caucaaaaau     1320

guggagaaga aaucuggcgg ggcuggaaag gugaccaaau ccgcccagaa ggcgcagaag     1380

gcuggcaaau ga                                                         1392


<210>  1336
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EFTUD2/m__Homo_sapiens__Q15029

<400>  1336

Met Asp Thr Asp Leu Tyr Asp Glu Phe Gly Asn Tyr Ile Gly Pro Glu 
1               5                   10                  15      


Leu Asp Ser Asp Glu Asp Asp Asp Glu Leu Gly Arg Glu Thr Lys Asp 
            20                  25                  30          


Leu Asp Glu Met Asp Asp Asp Asp Asp Asp Asp Asp Val Gly Asp His 
        35                  40                  45              


Asp Asp Asp His Pro Gly Met Glu Val Val Leu His Glu Asp Lys Lys 
    50                  55                  60                  


Tyr Tyr Pro Thr Ala Glu Glu Val Tyr Gly Pro Glu Val Glu Thr Ile 
65                  70                  75                  80  


Val Gln Glu Glu Asp Thr Gln Pro Leu Thr Glu Pro Ile Ile Lys Pro 
                85                  90                  95      


Val Lys Thr Lys Lys Phe Thr Leu Met Glu Gln Thr Leu Pro Val Thr 
            100                 105                 110         


Val Tyr Glu Met Asp Phe Leu Ala Asp Leu Met Asp Asn Ser Glu Leu 
        115                 120                 125             


Ile Arg Asn Val Thr Leu Cys Gly His Leu His His Gly Lys Thr Cys 
    130                 135                 140                 


Phe Val Asp Cys Leu Ile Glu Gln Thr His Pro Glu Ile Arg Lys Arg 
145                 150                 155                 160 


Tyr Asp Gln Asp Leu Cys Tyr Thr Asp Ile Leu Phe Thr Glu Gln Glu 
                165                 170                 175     


Arg Gly Val Gly Ile Lys Ser Thr Pro Val Thr Val Val Leu Pro Asp 
            180                 185                 190         


Thr Lys Gly Lys Ser Tyr Leu Phe Asn Ile Met Asp Thr Pro Gly His 
        195                 200                 205             


Val Asn Phe Ser Asp Glu Val Thr Ala Gly Leu Arg Ile Ser Asp Gly 
    210                 215                 220                 


Val Val Leu Phe Ile Asp Ala Ala Glu Gly Val Met Leu Asn Thr Glu 
225                 230                 235                 240 


Arg Leu Ile Lys His Ala Val Gln Glu Arg Leu Ala Val Thr Val Cys 
                245                 250                 255     


Ile Asn Lys Ile Asp Arg Leu Ile Leu Glu Leu Lys Leu Pro Pro Thr 
            260                 265                 270         


Asp Ala Tyr Tyr Lys Leu Arg His Ile Val Asp Glu Val Asn Gly Leu 
        275                 280                 285             


Ile Ser Met Tyr Ser Thr Asp Glu Asn Leu Ile Leu Ser Pro Leu Leu 
    290                 295                 300                 


Gly Asn Val Cys Phe Ser Ser Ser Gln Tyr Ser Ile Cys Phe Thr Leu 
305                 310                 315                 320 


Gly Ser Phe Ala Lys Ile Tyr Ala Asp Thr Phe Gly Asp Ile Asn Tyr 
                325                 330                 335     


Gln Glu Phe Ala Lys Arg Leu Trp Gly Asp Ile Tyr Phe Asn Pro Lys 
            340                 345                 350         


Thr Arg Lys Phe Thr Lys Lys Ala Pro Thr Ser Ser Ser Gln Arg Ser 
        355                 360                 365             


Phe Val Glu Phe Ile Leu Glu Pro Leu Tyr Lys Ile Leu Ala Gln Val 
    370                 375                 380                 


Val Gly Asp Val Asp Thr Ser Leu Pro Arg Thr Leu Asp Glu Leu Gly 
385                 390                 395                 400 


Ile His Leu Thr Lys Glu Glu Leu Lys Leu Asn Ile Arg Pro Leu Leu 
                405                 410                 415     


Arg Leu Val Cys Lys Lys Phe Phe Gly Glu Phe Thr Gly Phe Val Asp 
            420                 425                 430         


Met Cys Val Gln His Ile Pro Ser Pro Lys Val Gly Ala Lys Pro Lys 
        435                 440                 445             


Ile Glu His Thr Tyr Thr Gly Gly Val Asp Ser Asp Leu Gly Glu Ala 
    450                 455                 460                 


Met Ser Asp Cys Asp Pro Asp Gly Pro Leu Met Cys His Thr Thr Lys 
465                 470                 475                 480 


Met Tyr Ser Thr Asp Asp Gly Val Gln Phe His Ala Phe Gly Arg Val 
                485                 490                 495     


Leu Ser Gly Thr Ile His Ala Gly Gln Pro Val Lys Val Leu Gly Glu 
            500                 505                 510         


Asn Tyr Thr Leu Glu Asp Glu Glu Asp Ser Gln Ile Cys Thr Val Gly 
        515                 520                 525             


Arg Leu Trp Ile Ser Val Ala Arg Tyr His Ile Glu Val Asn Arg Val 
    530                 535                 540                 


Pro Ala Gly Asn Trp Val Leu Ile Glu Gly Val Asp Gln Pro Ile Val 
545                 550                 555                 560 


Lys Thr Ala Thr Ile Thr Glu Pro Arg Gly Asn Glu Glu Ala Gln Ile 
                565                 570                 575     


Phe Arg Pro Leu Lys Phe Asn Thr Thr Ser Val Ile Lys Ile Ala Val 
            580                 585                 590         


Glu Pro Val Asn Pro Ser Glu Leu Pro Lys Met Leu Asp Gly Leu Arg 
        595                 600                 605             


Lys Val Asn Lys Ser Tyr Pro Ser Leu Thr Thr Lys Val Glu Glu Ser 
    610                 615                 620                 


Gly Glu His Val Ile Leu Gly Thr Gly Glu Leu Tyr Leu Asp Cys Val 
625                 630                 635                 640 


Met His Asp Leu Arg Lys Met Tyr Ser Glu Ile Asp Ile Lys Val Ala 
                645                 650                 655     


Asp Pro Val Val Thr Phe Cys Glu Thr Val Val Glu Thr Ser Ser Leu 
            660                 665                 670         


Lys Cys Phe Ala Glu Thr Pro Asn Lys Lys Asn Lys Ile Thr Met Ile 
        675                 680                 685             


Ala Glu Pro Leu Glu Lys Gly Leu Ala Glu Asp Ile Glu Asn Glu Val 
    690                 695                 700                 


Val Gln Ile Thr Trp Asn Arg Lys Lys Leu Gly Glu Phe Phe Gln Thr 
705                 710                 715                 720 


Lys Tyr Asp Trp Asp Leu Leu Ala Ala Arg Ser Ile Trp Ala Phe Gly 
                725                 730                 735     


Pro Asp Ala Thr Gly Pro Asn Ile Leu Val Asp Asp Thr Leu Pro Ser 
            740                 745                 750         


Glu Val Asp Lys Ala Leu Leu Gly Ser Val Lys Asp Ser Ile Val Gln 
        755                 760                 765             


Gly Phe Gln Trp Gly Thr Arg Glu Gly Pro Leu Cys Asp Glu Leu Ile 
    770                 775                 780                 


Arg Asn Val Lys Phe Lys Ile Leu Asp Ala Val Val Ala Gln Glu Pro 
785                 790                 795                 800 


Leu His Arg Gly Gly Gly Gln Ile Ile Pro Thr Ala Arg Arg Val Val 
                805                 810                 815     


Tyr Ser Ala Phe Leu Met Ala Thr Pro Arg Leu Met Glu Pro Tyr Tyr 
            820                 825                 830         


Phe Val Glu Val Gln Ala Pro Ala Asp Cys Val Ser Ala Val Tyr Thr 
        835                 840                 845             


Val Leu Ala Arg Arg Arg Gly His Val Thr Gln Asp Ala Pro Ile Pro 
    850                 855                 860                 


Gly Ser Pro Leu Tyr Thr Ile Lys Ala Phe Ile Pro Ala Ile Asp Ser 
865                 870                 875                 880 


Phe Gly Phe Glu Thr Asp Leu Arg Thr His Thr Gln Gly Gln Ala Phe 
                885                 890                 895     


Ser Leu Ser Val Phe His His Trp Gln Ile Val Pro Gly Asp Pro Leu 
            900                 905                 910         


Asp Lys Ser Ile Val Ile Arg Pro Leu Glu Pro Gln Pro Ala Pro His 
        915                 920                 925             


Leu Ala Arg Glu Phe Met Ile Lys Thr Arg Arg Arg Lys Gly Leu Ser 
    930                 935                 940                 


Glu Asp Val Ser Ile Ser Lys Phe Phe Asp Asp Pro Met Leu Leu Glu 
945                 950                 955                 960 


Leu Ala Lys Gln Asp Val Val Leu Asn Tyr Pro Met 
                965                 970         


<210>  1337
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EFTUD2/m__Homo_sapiens__EAW51573

<400>  1337
auggauaccg acuuauauga ugaguuuggg aauuauauug gaccagagcu ugauucugau       60

gaagaugaug augaauuggg uagagagacc aaagaucuug augagaugga ugaugaugac      120

gacgacgaug acguaggaga ucaugacgau gaccacccug ggauggaggu ggugcugcau      180

gaggacaaga aguacuaccc aacagccgag gagguguaug guccugaggu ggagaccaua      240

guucaagagg aagacacuca gccucucaca gaacccauua uuaagccagu gaaaaccaag      300

aaauucacuc ugauggagca gacauuaccu guuacggugu augagaugga uuucuuggcg      360

gaucugaugg auaacucaga gcucaucaga aaugugaccc uuuguggaca ucuccaccau      420

ggcaagacau guuuugugga uuguuuaauu gaacagacuc acccggaaau cagaaagcgc      480

uaugaccaag aucugugcua uacugacauc cucuucacag agcaagagag agguguaggc      540

aucaaaagca cuccugugac aguggucuug ccagacacca aaggaaaauc uuaucucuuc      600

aauaucaugg acacuccagg acaugugaau uucucugaug aggucacagc uggcuugcgc      660

aucucagaug gagugguccu uuucauugau gcugcugagg gggugaugcu gaacacagag      720

cggcugauca agcaugcggu gcaggagagg cuggcaguca cugugugcau caacaagauu      780

gaccggcuga uccuggagcu gaagcugccu ccaacugaug cuuauuacaa gcugcgccac      840

auuguggaug aggucaaugg auuaauaagc auguauucca cugaugagaa ccugauccuu      900

uccccacucc uggguaacgu cugcuucucc agcucccagu acagcaucug cuucacgcug      960

ggcuccuuug ccaagaucua ugccgacacc uuuggugaca uuaauuacca agaauuugcu     1020

aaaagacucu ggggugacau cuacuucaac ccuaagacgc gaaaguucac caaaaaggcc     1080

ccaacuagca gcucccagag aaguuucgug gaguuuaucu uggagccucu uuauaagauc     1140

cucgcccagg uuguagguga cguggacacc agccucccac ggacccuaga cgagcuuggc     1200

auccaccuga cgaaggagga gcugaagcug aacauccgcc ccuugcucag gcuggucugc     1260

aaaaaguucu uuggcgaguu cacaggcuuu guggacaugu gugugcagca uaucccuucu     1320

ccaaaggugg gcgccaagcc caagauugag cacaccuaca ccgguggugu ggacuccgac     1380

cucggcgagg cuaugaguga cugugacccu gauggccccc ugaugugcca cacuacuaag     1440

auguacagca cagaugaugg aguccaguuu cacgccuuug gccgggugcu gaguggcacc     1500

auucaugcug ggcagccugu gaagguacug ggggagaacu acacccugga ggaugaggaa     1560

gacucccaga uaugcaccgu gggccgccuu uggaucucug uggccaggua ccacaucgag     1620

gugaaccgug uuccugcugg caacuggguu cugauugaag guguugauca accaauugug     1680

aagacagcaa ccauaaccga accccgaggc aaugaggagg cucagauuuu ccgacccuug     1740

aaguucaaua ccacaucugu uaucaagauu gcuguggagc cagucaaccc cucagagcug     1800

cccaagaugc uugauggccu gcgcaagguc aacaagagcu auccaucccu caccaccaag     1860

guggaggagu cuggcgagca ugugauccug ggcacugggg agcucuaccu ggacugugug     1920

augcaugauu ugcggaagau guacucagag auagacauca agguggcuga cccaguuguc     1980

acguuuugug agacgguggu ggaaacaucc ucccucaagu gcuuugcuga aacgccuaau     2040

aagaagaaca agaucaccau gauugcugag ccucuugaga agggccuggc agaggacaua     2100

gagaaugagg ugguccagau uacguggaac aggaagaagc ugggagaguu cuuccagacc     2160

aaguacgauu gggaucugcu ggcugcccgu uccaucuggg cuuuuggccc ugaugcgacu     2220

ggccccaaca uucuggugga ugauacucug cccucugagg uggacaaggc ucuucuuggu     2280

ucagugaagg acagcaucgu ucaagguuuc caguggggaa ccagggaggg cccccucugu     2340

gaugaauuga uucggaaugu caaguuuaag auccuggaug cggugguugc ccaggagccc     2400

cugcaccggg gcgggggcca gaucaucccc acagccagga gagucgucua cucugccuuc     2460

cucauggcua cuccucgucu gauggagccu uacuacuuug uagaggucca ggccccugca     2520

gauugcgucu cugcaguuua uaccguccug gccaggcgca gggggcacgu gacucaggau     2580

gcacccaucc caggcucccc ucuguacacc aucaaagcuu uuaucccggc caucgacucu     2640

uuuggcuuug agacugaucu ccggacucac acccagggac aagccuuuuc ucugucuguc     2700

uuccaccacu ggcagauugu gccuggugau ccccuggaca agagcauugu cauccgcccc     2760

uuggagccac agccagcucc ucaccuggcc cgggaauuca ugaucaaaac ccgccguagg     2820

aagggccuca gugaagaugu gagcaucagc aaauucuucg augauccuau guugcuggaa     2880

cuugccaaac aggauguugu gcucaauuac cccauguga                            2919


<210>  1338
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EFTUD2/m__Homo_sapiens__EAW51573

<400>  1338
auggacaccg accuguacga cgaguucggc aacuacaucg ggcccgagcu cgacagcgac       60

gaggacgacg acgagcuggg ccgcgagacc aaggaccugg acgagaugga cgacgacgac      120

gacgacgacg acguggggga ccacgacgac gaccacccgg gcauggaggu cgugcuccac      180

gaggacaaga aguacuaccc cacggccgag gagguguacg ggcccgaggu cgagaccauc      240

gugcaggagg aggacaccca gccccugacc gagccgauca ucaagcccgu gaagacgaag      300

aaguucaccc ugauggagca gacccucccc gucaccgugu acgagaugga cuuccuggcc      360

gaccugaugg acaacuccga gcucauccgg aacgugacgc ugugcggcca ccuccaccac      420

ggcaagaccu gcuucgucga cugccucauc gagcagaccc accccgagau ccgcaagcgg      480

uacgaccagg accugugcua caccgacauc cuguucacgg agcaggagcg cggggugggc      540

aucaagagca ccccggugac cgucgugcuc cccgacacca aggggaaguc cuaccuguuc      600

aacaucaugg acacgcccgg ccacgugaac uucagcgacg aggucaccgc ggggcugcgg      660

aucuccgacg gcguggugcu guucaucgac gccgccgagg gcgucaugcu gaacaccgag      720

cgccugauca agcacgccgu gcaggagcgg cucgccguga ccgucugcau caacaagauc      780

gaccgccuga uccuggagcu caagcugccc ccgacggacg cguacuacaa gcugcggcac      840

aucguggacg aggugaacgg gcucaucagc auguacucca ccgacgagaa ccugauccug      900

agcccccucc ugggcaacgu cugcuucucc agcucccagu acagcaucug cuucacccug      960

ggguccuucg ccaagaucua cgccgacacc uucggcgaca ucaacuacca ggaguucgcc     1020

aagcgccucu ggggcgacau cuacuucaac cccaagacgc ggaaguucac caagaaggcg     1080

cccaccagcu ccagccagcg cuccuucgug gaguucaucc uggagccgcu guacaagauc     1140

cucgcccagg ucguggggga cguggacacc agccugcccc ggacgcugga cgagcucggc     1200

auccaccuga ccaaggagga gcugaagcuc aacauccgcc cccugcugcg gcucgucugc     1260

aagaaguucu ucggggaguu caccggcuuc guggacaugu gcgugcagca cauccccucc     1320

ccgaaggucg gggccaagcc caagaucgag cacaccuaca cgggcggcgu ggacagcgac     1380

cugggggagg ccaugagcga cugcgacccc gacggccccc ugaugugcca caccaccaag     1440

auguacucca ccgacgacgg ggugcaguuc cacgccuucg gccgcguccu cagcgggacg     1500

auccacgcgg gccagccggu gaaggugcug ggcgagaacu acacccugga ggacgaggag     1560

gacucccaga ucugcaccgu cgggcggcug uggaucagcg uggcccgcua ccacaucgag     1620

gugaaccggg uccccgccgg caacugggug cucaucgagg ggguggacca gcccaucguc     1680

aagaccgcca ccaucacgga gccccgcggc aacgaggagg cccagaucuu ccggccgcug     1740

aaguucaaca ccaccuccgu gaucaagauc gcgguggagc ccgucaaccc cagcgagcug     1800

ccgaagaugc ucgacgggcu gcgcaaggug aacaaguccu accccagccu gaccacgaag     1860

guggaggagu ccggcgagca cgucauccuc ggcaccgggg agcuguaccu ggacugcgug     1920

augcacgacc uccgcaagau guacagcgag aucgacauca agguggccga ccccgucgug     1980

accuucugcg agaccguggu cgagacgucc agccugaagu gcuucgccga gacccccaac     2040

aagaagaaca agaucaccau gaucgccgag ccgcuggaga agggccucgc cgaggacauc     2100

gagaacgagg uggugcagau caccuggaac cggaagaagc ugggggaguu cuuccagacg     2160

aaguacgacu gggaccugcu cgcggcccgc uccaucuggg ccuucggccc cgacgccacc     2220

ggccccaaca uccuggucga cgacacccug cccagcgagg uggacaaggc ccuccugggg     2280

uccgugaagg acagcaucgu ccagggcuuc caguggggga cccgggaggg cccgcugugc     2340

gacgagcuca uccgcaacgu gaaguucaag auccuggacg cgguggucgc ccaggagccc     2400

cugcaccgcg ggggcggcca gaucaucccc acggcccggc ggguggugua cuccgccuuc     2460

cucauggcga cgccccgccu gauggagccg uacuacuucg ucgaggugca ggcccccgcc     2520

gacugcguga gcgccgucua caccgugcug gcccggcgcc gggggcacgu gacccaggac     2580

gcgcccaucc ccggcucccc gcucuacacc aucaaggccu ucauccccgc caucgacagc     2640

uucggguucg agaccgaccu gcgcacccac acccagggcc aggccuucag ccuguccguc     2700

uuccaccacu ggcagaucgu gcccggggac ccccucgaca agagcaucgu gauccggccg     2760

cuggagcccc agcccgcgcc ccaccuggcc cgcgaguuca ugaucaagac gcggcgccgg     2820

aagggccucu ccgaggacgu cagcaucucc aaguucuucg acgacccgau gcugcuggag     2880

cucgccaagc aggacguggu ccugaacuac cccauguga                            2919


<210>  1339
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EFTUD2/m__Homo_sapiens__EAW51573

<400>  1339
auggacaccg accucuacga cgaguucggc aacuacaucg gccccgagcu cgacuccgac       60

gaggacgacg acgagcucgg ccgcgagacc aaggaccucg acgagaugga cgacgacgac      120

gacgacgacg acgucggcga ccacgacgac gaccaccccg gcauggaggu cguccuccac      180

gaggacaaga aguacuaccc caccgccgag gaggucuacg gccccgaggu cgagaccauc      240

guccaggagg aggacaccca gccccucacc gagcccauca ucaagcccgu caagaccaag      300

aaguucaccc ucauggagca gacccucccc gucaccgucu acgagaugga cuuccucgcc      360

gaccucaugg acaacuccga gcucauccgc aacgucaccc ucugcggcca ccuccaccac      420

ggcaagaccu gcuucgucga cugccucauc gagcagaccc accccgagau ccgcaagcgc      480

uacgaccagg accucugcua caccgacauc cucuucaccg agcaggagcg cggcgucggc      540

aucaagucca cccccgucac cgucguccuc cccgacacca agggcaaguc cuaccucuuc      600

aacaucaugg acacccccgg ccacgucaac uucuccgacg aggucaccgc cggccuccgc      660

aucuccgacg gcgucguccu cuucaucgac gccgccgagg gcgucaugcu caacaccgag      720

cgccucauca agcacgccgu ccaggagcgc cucgccguca ccgucugcau caacaagauc      780

gaccgccuca uccucgagcu caagcucccc cccaccgacg ccuacuacaa gcuccgccac      840

aucgucgacg aggucaacgg ccucaucucc auguacucca ccgacgagaa ccucauccuc      900

uccccccucc ucggcaacgu cugcuucucc uccucccagu acuccaucug cuucacccuc      960

ggcuccuucg ccaagaucua cgccgacacc uucggcgaca ucaacuacca ggaguucgcc     1020

aagcgccucu ggggcgacau cuacuucaac cccaagaccc gcaaguucac caagaaggcc     1080

cccaccuccu ccucccagcg cuccuucguc gaguucaucc ucgagccccu cuacaagauc     1140

cucgcccagg ucgucggcga cgucgacacc ucccuccccc gcacccucga cgagcucggc     1200

auccaccuca ccaaggagga gcucaagcuc aacauccgcc cccuccuccg ccucgucugc     1260

aagaaguucu ucggcgaguu caccggcuuc gucgacaugu gcguccagca cauccccucc     1320

cccaaggucg gcgccaagcc caagaucgag cacaccuaca ccggcggcgu cgacuccgac     1380

cucggcgagg ccauguccga cugcgacccc gacggccccc ucaugugcca caccaccaag     1440

auguacucca ccgacgacgg cguccaguuc cacgccuucg gccgcguccu cuccggcacc     1500

auccacgccg gccagcccgu caagguccuc ggcgagaacu acacccucga ggacgaggag     1560

gacucccaga ucugcaccgu cggccgccuc uggaucuccg ucgcccgcua ccacaucgag     1620

gucaaccgcg uccccgccgg caacuggguc cucaucgagg gcgucgacca gcccaucguc     1680

aagaccgcca ccaucaccga gccccgcggc aacgaggagg cccagaucuu ccgcccccuc     1740

aaguucaaca ccaccuccgu caucaagauc gccgucgagc ccgucaaccc cuccgagcuc     1800

cccaagaugc ucgacggccu ccgcaagguc aacaaguccu accccucccu caccaccaag     1860

gucgaggagu ccggcgagca cgucauccuc ggcaccggcg agcucuaccu cgacugcguc     1920

augcacgacc uccgcaagau guacuccgag aucgacauca aggucgccga ccccgucguc     1980

accuucugcg agaccgucgu cgagaccucc ucccucaagu gcuucgccga gacccccaac     2040

aagaagaaca agaucaccau gaucgccgag ccccucgaga agggccucgc cgaggacauc     2100

gagaacgagg ucguccagau caccuggaac cgcaagaagc ucggcgaguu cuuccagacc     2160

aaguacgacu gggaccuccu cgccgcccgc uccaucuggg ccuucggccc cgacgccacc     2220

ggccccaaca uccucgucga cgacacccuc cccuccgagg ucgacaaggc ccuccucggc     2280

uccgucaagg acuccaucgu ccagggcuuc caguggggca cccgcgaggg cccccucugc     2340

gacgagcuca uccgcaacgu caaguucaag auccucgacg ccgucgucgc ccaggagccc     2400

cuccaccgcg gcggcggcca gaucaucccc accgcccgcc gcgucgucua cuccgccuuc     2460

cucauggcca ccccccgccu cauggagccc uacuacuucg ucgaggucca ggcccccgcc     2520

gacugcgucu ccgccgucua caccguccuc gcccgccgcc gcggccacgu cacccaggac     2580

gcccccaucc ccggcucccc ccucuacacc aucaaggccu ucauccccgc caucgacucc     2640

uucggcuucg agaccgaccu ccgcacccac acccagggcc aggccuucuc ccucuccguc     2700

uuccaccacu ggcagaucgu ccccggcgac ccccucgaca aguccaucgu cauccgcccc     2760

cucgagcccc agcccgcccc ccaccucgcc cgcgaguuca ugaucaagac ccgccgccgc     2820

aagggccucu ccgaggacgu cuccaucucc aaguucuucg acgaccccau gcuccucgag     2880

cucgccaagc aggacgucgu ccucaacuac cccauguga                            2919


<210>  1340
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EFTUD2/m__Homo_sapiens__EAW51573

<400>  1340
auggacaccg aucuguacga cgaguucggc aacuauaucg ggcccgaacu cgauagcgac       60

gaggaugacg augaacuugg aagagagaca aaggaccugg augaaaugga cgaugacgau      120

gacgacgaug acguggguga ucacgacgau gaccauccug gcauggaggu cguuuugcac      180

gaggauaaaa aguacuaucc aacugccgaa gagguguacg ggccggaagu agagacgauu      240

gugcaggagg aagacaccca acccuuaaca gagccuauaa ucaaaccagu caagacuaaa      300

aaguuuaccc ugauggaaca gacacuaccc gugaccguuu augagaugga uuuccucgcu      360

gaccugaugg auaauuccga acuuauuagg aacgugacuc ugugcggaca uuugcaccau      420

ggcaagacau guuuugucga cugccucauc gagcagaccc acccugagau ucggaaacgc      480

uacgaccagg aucuguguua uacggacauc cuguucacug aacaagagcg aggugugggg      540

auaaagucua ccccaguaac aguugugcuc cccgauacua aaggaaaguc auacuuauuu      600

aauaucaugg acaccccugg ccacgucaac uucagugaug aagugacagc aggccugcgu      660

auuagcgacg gggugguccu uuuuaucgau gccgcggagg gaguuauguu gaauaccgaa      720

agacugauua aacaugcugu gcaggagagg cuagccguaa cggugugcau caacaagaua      780

gaccggcuca uucuggagcu uaagcugcca ccgacugaug cauacuauaa auugcgccac      840

aucgucgacg aagugaaugg ucucauuucc auguacucua cagaugagaa ccugaucuua      900

ucgccccugc ucggcaaugu uuguuucuca agcagucagu auuccaucug cuuuacccuu      960

gggucuuucg ccaagauuua cgcugacacu uuuggagaua uaaacuauca ggaguucgca     1020

aaaagacugu ggggcgacau cuacuuuaau ccuaagacaa ggaaauucac caagaaagcc     1080

ccaacgagcu ccucacaacg gaguuucgug gaauuuauuu uggaaccccu auauaagauc     1140

cuggcucagg ucguggguga cguagauacc agccucccuc gcacacugga cgagcuuggg     1200

auacaucuga cuaaggagga auugaaacuc aacauucgac cacuguuaag acugguuugu     1260

aagaaauucu uuggagaguu caccggcuuu guggauaugu gcguccagca cauccccucu     1320

ccgaaggugg gcgccaaacc uaagaucgaa cacacauaca cugggggagu cgacuccgau     1380

cuaggugagg cgaugucaga cugugauccc gacggcccac ucaugugcca uaccacaaag     1440

auguacagca ccgaugacgg ggugcaguuc cacgcauuug gaaggguucu gaguggcacu     1500

auucaugccg gucaaccugu gaaaguacuu ggggagaauu auacguugga agaugaggaa     1560

gacucucaga ucuguacagu cggccggcug uggauuuccg uggcucguua ccacauagag     1620

guuaaccgcg ugcccgccgg aaauuggguc cucaucgaag gcguggauca gccaauugua     1680

aagaccgcaa cuaucaccga gcccagaggg aacgaggaag cucaaaucuu caggccucug     1740

aaauuuaaca caaccagcgu gauuaagaua gccguugagc cagucaaucc gucggaacuu     1800

cccaaaaugc uggacggauu gcggaaggug aacaagucuu auccuucccu cacuacaaaa     1860

guggaggaau caggugagca ugucauccug ggcacggggg aguuauaccu ggacugcguu     1920

augcacgauc uacgaaagau guauagugaa auugacauca aaguggcgga uccaguggua     1980

accuucugcg agacugucgu ggaaacaagc ucccucaagu guuuugccga gacccccaau     2040

aaaaagaaca agauuacaau gaucgcagaa ccucuggaga aaggacuugc ugaggacaua     2100

gaaaaugagg uugugcagau cacuuggaac cgcaagaaau ugggcgaguu cuuucagacc     2160

aaguacgauu gggaccugcu cgccgcuaga ucuauuuggg ccuucggucc agaugcaacg     2220

gggcccaaua uccuggucga cgauaccuua ccgagcgaag uggacaaagc ccugcuuggc     2280

ucaguuaagg auaguauugu gcagggauuc caauggggca caagggaggg gccuuugugc     2340

gacgaacuca uccggaacgu aaaauuuaag auacuggacg cugucguggc gcaggagcca     2400

cuacaccgcg gagguggcca gauuaucccc acugcaagaa ggguggucua uuccgccuuc     2460

cugauggcua ccccucgucu cauggaaccc uacuacuuug uugaggugca ggccccagca     2520

gauuguguaa gcgccgugua uacaguccug gcucggcgaa gagggcaugu gacucaagac     2580

gccccuauuc ccggaucucc acuuuacacc aucaaggcau ucauaccggc gaucgauuca     2640

uuuggcuucg aaacggacuu gaggacacac acccaggguc aggcuuuuag ucugagcguu     2700

uuccaucacu ggcagauugu gccuggggau cccuuagaca aauccaucgu cauucgccca     2760

cucgagcccc aaccugcccc acaccuggca cgggaguuua ugaucaagac uagaaggcgc     2820

aaaggccuuu cugaagaugu gucgauaagc aaguucuuug acgaucccau gcuguuggag     2880

cucgccaaac aggacguugu gcugaauuau ccuauguga                            2919


<210>  1341
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EFTUD2/m__Homo_sapiens__EAW51573

<400>  1341
auggacaccg accuguacga cgaguucggc aacuacaucg gccccgagcu ggacagcgac       60

gaggacgacg acgagcuggg cagagagacc aaggaccugg acgagaugga cgacgacgac      120

gacgacgacg acgugggcga ccacgacgac gaccaccccg gcauggaggu ggugcugcac      180

gaggacaaga aguacuaccc caccgccgag gagguguacg gccccgaggu ggagaccauc      240

gugcaggagg aggacaccca gccccugacc gagcccauca ucaagcccgu gaagaccaag      300

aaguucaccc ugauggagca gacccugccc gugaccgugu acgagaugga cuuccuggcc      360

gaccugaugg acaacagcga gcugaucaga aacgugaccc ugugcggcca ccugcaccac      420

ggcaagaccu gcuucgugga cugccugauc gagcagaccc accccgagau cagaaagaga      480

uacgaccagg accugugcua caccgacauc cuguucaccg agcaggagag aggcgugggc      540

aucaagagca cccccgugac cguggugcug cccgacacca agggcaagag cuaccuguuc      600

aacaucaugg acacccccgg ccacgugaac uucagcgacg aggugaccgc cggccugaga      660

aucagcgacg gcguggugcu guucaucgac gccgccgagg gcgugaugcu gaacaccgag      720

agacugauca agcacgccgu gcaggagaga cuggccguga ccgugugcau caacaagauc      780

gacagacuga uccuggagcu gaagcugccc cccaccgacg ccuacuacaa gcugagacac      840

aucguggacg aggugaacgg ccugaucagc auguacagca ccgacgagaa ccugauccug      900

agcccccugc ugggcaacgu gugcuucagc agcagccagu acagcaucug cuucacccug      960

ggcagcuucg ccaagaucua cgccgacacc uucggcgaca ucaacuacca ggaguucgcc     1020

aagagacugu ggggcgacau cuacuucaac cccaagacca gaaaguucac caagaaggcc     1080

cccaccagca gcagccagag aagcuucgug gaguucaucc uggagccccu guacaagauc     1140

cuggcccagg uggugggcga cguggacacc agccugccca gaacccugga cgagcugggc     1200

auccaccuga ccaaggagga gcugaagcug aacaucagac cccugcugag acuggugugc     1260

aagaaguucu ucggcgaguu caccggcuuc guggacaugu gcgugcagca cauccccagc     1320

cccaaggugg gcgccaagcc caagaucgag cacaccuaca ccggcggcgu ggacagcgac     1380

cugggcgagg ccaugagcga cugcgacccc gacggccccc ugaugugcca caccaccaag     1440

auguacagca ccgacgacgg cgugcaguuc cacgccuucg gcagagugcu gagcggcacc     1500

auccacgccg gccagcccgu gaaggugcug ggcgagaacu acacccugga ggacgaggag     1560

gacagccaga ucugcaccgu gggcagacug uggaucagcg uggccagaua ccacaucgag     1620

gugaacagag ugcccgccgg caacugggug cugaucgagg gcguggacca gcccaucgug     1680

aagaccgcca ccaucaccga gcccagaggc aacgaggagg cccagaucuu cagaccccug     1740

aaguucaaca ccaccagcgu gaucaagauc gccguggagc ccgugaaccc cagcgagcug     1800

cccaagaugc uggacggccu gagaaaggug aacaagagcu accccagccu gaccaccaag     1860

guggaggaga gcggcgagca cgugauccug ggcaccggcg agcuguaccu ggacugcgug     1920

augcacgacc ugagaaagau guacagcgag aucgacauca agguggccga ccccguggug     1980

accuucugcg agaccguggu ggagaccagc agccugaagu gcuucgccga gacccccaac     2040

aagaagaaca agaucaccau gaucgccgag ccccuggaga agggccuggc cgaggacauc     2100

gagaacgagg uggugcagau caccuggaac agaaagaagc ugggcgaguu cuuccagacc     2160

aaguacgacu gggaccugcu ggccgccaga agcaucuggg ccuucggccc cgacgccacc     2220

ggccccaaca uccuggugga cgacacccug cccagcgagg uggacaaggc ccugcugggc     2280

agcgugaagg acagcaucgu gcagggcuuc caguggggca ccagagaggg cccccugugc     2340

gacgagcuga ucagaaacgu gaaguucaag auccuggacg ccgugguggc ccaggagccc     2400

cugcacagag gcggcggcca gaucaucccc accgccagaa gaguggugua cagcgccuuc     2460

cugauggcca cccccagacu gauggagccc uacuacuucg uggaggugca ggcccccgcc     2520

gacugcguga gcgccgugua caccgugcug gccagaagaa gaggccacgu gacccaggac     2580

gcccccaucc ccggcagccc ccuguacacc aucaaggccu ucauccccgc caucgacagc     2640

uucggcuucg agaccgaccu gagaacccac acccagggcc aggccuucag ccugagcgug     2700

uuccaccacu ggcagaucgu gcccggcgac ccccuggaca agagcaucgu gaucagaccc     2760

cuggagcccc agcccgcccc ccaccuggcc agagaguuca ugaucaagac cagaagaaga     2820

aagggccuga gcgaggacgu gagcaucagc aaguucuucg acgaccccau gcugcuggag     2880

cuggccaagc aggacguggu gcugaacuac cccauguga                            2919


<210>  1342
<211>  2919
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EFTUD2/m__Homo_sapiens__EAW51573

<400>  1342
auggacaccg aucuguacga cgaguucggc aacuauaucg ggcccgaacu cgauagcgac       60

gaggaugacg augaacuggg aagagagaca aaggaccuug augaaaugga cgaugacgau      120

gacgacgaug acgugggcga ucacgacgau gaccauccug ggauggaggu cguucugcac      180

gaggauaaaa aguacuaucc gacggccgaa gagguguacg gacccgaagu ggagaccauu      240

guccaggagg aagacacaca accucucacc gagcccauca uuaaaccugu gaagaccaaa      300

aaguuuaccc ugauggaaca gacacuuccc guuaccgugu augagaugga uuuccuggcu      360

gaccucaugg auaauuccga acugauccgg aacgucacgc ugugcggcca ucuccaccau      420

gggaagaccu guuuugugga cugccugauu gagcagacac acccugagau ccgcaaaaga      480

uacgaccagg aucuuuguua uaccgacauc cuguucacag aacaagagcg gggaguuggc      540

auuaagucua ccccggugac ggucgugcuc cccgauacaa aaggcaagag cuaccuguuu      600

aauaucaugg acaccccugg gcacgugaac uucuccgaug aagucacagc cggacuucgc      660

auuucugacg gcguugugcu guuuaucgau gcggcugagg gggugaugcu caauaccgaa      720

agacugauua aacaugccgu ccaggagcgg cuggccguga ccguuugcau caacaagauu      780

gaccgccuca uccuggagcu uaagcugccc ccuacagaug cuuacuauaa acucagacac      840

aucguggacg aagucaaugg acugauuagc auguacucca cggaugagaa ccuuauccug      900

ucuccccucc ugggcaaugu guguuucagc uccagccagu auucuauuug cuuuacccug      960

ggguccuucg ccaagaucua cgcugacaca uuuggagaua uuaacuauca ggaguucgcc     1020

aaacggcucu ggggcgacau cuacuuuaau ccgaagaccc gcaaauucac aaagaaagcg     1080

ccuaccagca gcucccaaag aucuuucguu gaauuuaucc uggaaccccu uuauaagauu     1140

cuggcccagg uggucggcga cguggauacg ucucucccuc ggacacugga cgagcuuggg     1200

auccaucuga ccaaggagga acucaaacug aacauucgcc cccugcucag acuggucugu     1260

aagaaauucu uuggagaguu caccggcuuu guggauaugu gcguucagca cauccccucc     1320

ccuaaggugg gggcuaaacc gaagauugaa cacacauaca ccggaggcgu cgacagcgau     1380

cuuggggagg ccauguccga cugugauccc gacggaccuc ugaugugcca uacaacgaag     1440

auguacucua ccgaugacgg cgugcaguuc cacgcuuuug gccggguucu cagcgggaca     1500

auccaugccg gacaacccgu gaaaguccug ggcgagaauu auacccugga agaugaggaa     1560

gacucccaga ucuguacagu ggggcgccuu uggauuagcg uggcgagaua ccacaucgag     1620

guuaaccggg ucccugccgg aaauugggug cucauugaag gcguggauca gcccaucguc     1680

aagaccgcua cgauuaccga gccgagaggg aacgaggaag cccaaaucuu ccgcccucug     1740

aaauuuaaca caaccucugu gauuaagauc gcuguugagc ccgugaaucc uuccgaacug     1800

cccaaaaugc ucgacggccu gcggaagguc aacaagagcu auccuucucu uacaaccaaa     1860

guggaggaaa gcggagagca uguuauccug ggcacggggg agcucuaccu ggacugcgug     1920

augcacgauc ugagaaagau guauuccgaa auugacauca aagucgccga ucccgugguu     1980

acauucugcg agaccguggu cgaaacaucu agccuuaagu guuuugccga gaccccgaau     2040

aaaaagaaca agauuaccau gaucgcugaa ccucucgaga aaggacuggc ggaggacauu     2100

gaaaaugagg uggugcagau cacauggaac cgcaagaaac ugggcgaguu cuuucagacg     2160

aaguacgauu gggaccuccu ggccgcucgg uccaucuggg ccuucgggcc cgaugccacc     2220

ggacccaaua uucuugucga cgauacacug ccuagcgaag uugacaaagc ucuccugggc     2280

ucugugaagg auuccaucgu gcagggguuc caauggggca ccagagaggg accgcugugc     2340

gacgaacuua uucgcaacgu caaauuuaag auccucgacg ccgugguugc gcaggagccc     2400

cugcaccggg gcgggggaca gauuaucccu acagcuagac gcguggucua uagcgccuuc     2460

cugauggcca caccccggcu cauggaaccu uacuacuuug uggagguuca ggcucccgcc     2520

gauugugugu cugcugucua uacggugcug gccagacgcc ggggccaugu uacacaagac     2580

gcgccuaucc ccgggucccc gcuuuacacc auuaaggccu ucaucccugc uauugauagc     2640

uuuggauucg aaaccgaccu gagaacacac acccagggcc aggccuuuuc ccucucugug     2700

uuccaucacu ggcagaucgu ccccggggau ccucuggaca aaagcauugu gauccggccc     2760

cuggagccgc aaccugcucc ccaccuugcc cgcgaguuua ugaucaagac aagacggaga     2820

aaaggccucu ccgaagaugu gucuauuagc aaguucuuug acgauccuau gcugcuggag     2880

cucgcgaaac aggacgucgu ucugaauuau cccauguga                            2919


<210>  1343
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__A0A0B4J1Y5

<400>  1343

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Ser Tyr Ile Val Ser His Phe Pro Arg Ser Phe Tyr Lys Met Ser Val 
                645                 650                 655     


His 
    


<210>  1344
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__EAW50963

<400>  1344
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaguu ugccaaggca cgaguaacaa gcucacgcag      120

uugggcacuu uugaagauca uuuucucagc cuccagagga uguucaauaa cugugaggug      180

guccuuggga auuuggaaau uaccuaugug cagaggaauu augaucuuuc cuucuuaaag      240

accauccagg agguggcugg uuauguccuc auugcccuca acacagugga gcgaauuccu      300

uuggaaaacc ugcagaucau cagaggaaau auguacuacg aaaauuccua ugccuuagca      360

gucuuaucua acuaugaugc aaauaaaacc ggacugaagg agcugcccau gagaaauuua      420

caggaaaucc ugcauggcgc cgugcgguuc agcaacaacc cugcccugug caacguggag      480

agcauccagu ggcgggacau agucagcagu gacuuucuca gcaacauguc gauggacuuc      540

cagaaccacc ugggcagcug ccaaaagugu gauccaagcu gucccaaugg gagcugcugg      600

ggugcaggag aggagaacug ccagaaacug accaaaauca ucugugccca gcagugcucc      660

gggcgcugcc guggcaaguc ccccagugac ugcugccaca accagugugc ugcaggcugc      720

acaggccccc gggagagcga cugccugguc ugccgcaaau uccgagacga agccacgugc      780

aaggacaccu gccccccacu caugcucuac aaccccacca cguaccagau ggaugugaac      840

cccgagggca aauacagcuu uggugccacc ugcgugaaga aguguccccg uaauuaugug      900

gugacagauc acggcucgug cguccgagcc uguggggccg acagcuauga gauggaggaa      960

gacggcgucc gcaaguguaa gaagugcgaa gggccuugcc gcaaagugug uaacggaaua     1020

gguauuggug aauuuaaaga cucacucucc auaaaugcua cgaauauuaa acacuucaaa     1080

aacugcaccu ccaucagugg cgaucuccac auccugccgg uggcauuuag gggugacucc     1140

uucacacaua cuccuccucu ggauccacag gaacuggaua uucugaaaac cguaaaggaa     1200

aucacagggu uuuugcugau ucaggcuugg ccugaaaaca ggacggaccu ccaugccuuu     1260

gagaaccuag aaaucauacg cggcaggacc aagcaacaug gucaguuuuc ucuugcaguc     1320

gucagccuga acauaacauc cuugggauua cgcucccuca aggagauaag ugauggagau     1380

gugauaauuu caggaaacaa aaauuugugc uaugcaaaua caauaaacug gaaaaaacug     1440

uuugggaccu ccggucagaa aaccaaaauu auaagcaaca gaggugaaaa cagcugcaag     1500

gccacaggcc aggucugcca ugccuugugc ucccccgagg gcugcugggg cccggagccc     1560

agggacugcg ucucuugccg gaaugucagc cgaggcaggg aaugcgugga caagugcaac     1620

cuucuggagg gugagccaag ggaguuugug gagaacucug agugcauaca gugccaccca     1680

gagugccugc cucaggccau gaacaucacc ugcacaggac ggggaccaga caacuguauc     1740

cagugugccc acuacauuga cggcccccac ugcgucaaga ccugcccggc aggagucaug     1800

ggagaaaaca acacccuggu cuggaaguac gcagacgccg gccaugugug ccaccugugc     1860

cauccaaacu gcaccuacgg augcacuggg ccaggucuug aaggcugucc aacgaaugga     1920

agcuacauag ugucucacuu uccaagauca uucuacaaga ugucagugca c              1971


<210>  1345
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__EAW50963

<400>  1345
augcgcccca gcggcaccgc cggggccgcg cugcucgccc ugcuggccgc ccucugcccg       60

gccucccggg cgcuggagga gaagaaggug ugccagggca ccagcaacaa gcugacgcag      120

cucgggaccu ucgaggacca cuuccugucc cugcagcgca uguucaacaa cugcgagguc      180

gugcucggca accuggagau caccuacgug cagcggaacu acgaccugag cuuccucaag      240

accauccagg aggucgccgg guacgugcug aucgcccuga acacggugga gcgcaucccc      300

cucgagaacc ugcagaucau ccggggcaac auguacuacg agaacuccua cgcccuggcg      360

guccucagca acuacgacgc caacaagacc ggccugaagg agcugcccau gcgcaaccuc      420

caggagaucc ugcacggggc cgugcgguuc uccaacaacc ccgcccugug caacguggag      480

agcauccagu ggcgcgacau cgucuccagc gacuuccucu ccaacaugag cauggacuuc      540

cagaaccacc ugggcuccug ccagaagugc gacccgagcu gccccaacgg guccugcugg      600

ggcgccgggg aggagaacug ccagaagcug accaagauca ucugcgcgca gcagugcagc      660

ggccggugcc gcggcaaguc ccccagcgac ugcugccaca accagugcgc cgccgggugc      720

accggccccc gggaguccga cugccucgug ugccgcaagu uccgggacga ggccacgugc      780

aaggacacgu gcccgccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggga aguacagcuu cggcgcgacc ugcgucaaga agugcccgcg caacuacgug      900

gugaccgacc acggcagcug cguccgggcc ugcggggccg acuccuacga gauggaggag      960

gacggcgugc gcaagugcaa gaagugcgag gggcccugcc ggaaggugug caacggcauc     1020

gggaucggcg aguucaagga cagccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucuccgg cgaccugcac auccugcccg ucgccuuccg cggggacagc     1140

uucacgcaca cgcccccgcu cgacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccuccugau ccaggccugg cccgagaacc ggaccgaccu gcacgcguuc     1260

gagaaccucg agaucauccg cgggcggacc aagcagcacg gccaguucuc ccuggccgug     1320

gucagccuga acaucaccuc ccucgggcug cgcagccuga aggagaucuc cgacggcgac     1380

gugaucauca gcggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcug     1440

uucgggacgu ccggccagaa gaccaagauc aucagcaacc gcggggagaa cuccugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg ggugcugggg cccggagccc     1560

cgggacugcg ucuccugccg caacgugagc cggggccgcg agugcgucga caagugcaac     1620

cuccuggagg gggagccccg ggaguucgug gagaacuccg agugcaucca gugccacccc     1680

gagugccugc cgcaggcgau gaacaucacg ugcaccggcc gcgggcccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgucaug     1800

ggggagaaca acacccuggu guggaaguac gccgacgcgg gccacgugug ccaccucugc     1860

cacccgaacu gcaccuacgg gugcacgggc cccgggcugg agggcugccc caccaacggc     1920

agcuacaucg ucagccacuu cccgcggucc uucuacaaga ugagcgugca c              1971


<210>  1346
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__EAW50963

<400>  1346
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagguc ugccagggca ccuccaacaa gcucacccag      120

cucggcaccu ucgaggacca cuuccucucc cuccagcgca uguucaacaa cugcgagguc      180

guccucggca accucgagau caccuacguc cagcgcaacu acgaccucuc cuuccucaag      240

accauccagg aggucgccgg cuacguccuc aucgcccuca acaccgucga gcgcaucccc      300

cucgagaacc uccagaucau ccgcggcaac auguacuacg agaacuccua cgcccucgcc      360

guccucucca acuacgacgc caacaagacc ggccucaagg agcuccccau gcgcaaccuc      420

caggagaucc uccacggcgc cguccgcuuc uccaacaacc ccgcccucug caacgucgag      480

uccauccagu ggcgcgacau cgucuccucc gacuuccucu ccaacauguc cauggacuuc      540

cagaaccacc ucggcuccug ccagaagugc gaccccuccu gccccaacgg cuccugcugg      600

ggcgccggcg aggagaacug ccagaagcuc accaagauca ucugcgccca gcagugcucc      660

ggccgcugcc gcggcaaguc ccccuccgac ugcugccaca accagugcgc cgccggcugc      720

accggccccc gcgaguccga cugccucguc ugccgcaagu uccgcgacga ggccaccugc      780

aaggacaccu gccccccccu caugcucuac aaccccacca ccuaccagau ggacgucaac      840

cccgagggca aguacuccuu cggcgccacc ugcgucaaga agugcccccg caacuacguc      900

gucaccgacc acggcuccug cguccgcgcc ugcggcgccg acuccuacga gauggaggag      960

gacggcgucc gcaagugcaa gaagugcgag ggccccugcc gcaaggucug caacggcauc     1020

ggcaucggcg aguucaagga cucccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcaccu ccaucuccgg cgaccuccac auccuccccg ucgccuuccg cggcgacucc     1140

uucacccaca cccccccccu cgacccccag gagcucgaca uccucaagac cgucaaggag     1200

aucaccggcu uccuccucau ccaggccugg cccgagaacc gcaccgaccu ccacgccuuc     1260

gagaaccucg agaucauccg cggccgcacc aagcagcacg gccaguucuc ccucgccguc     1320

gucucccuca acaucaccuc ccucggccuc cgcucccuca aggagaucuc cgacggcgac     1380

gucaucaucu ccggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcuc     1440

uucggcaccu ccggccagaa gaccaagauc aucuccaacc gcggcgagaa cuccugcaag     1500

gccaccggcc aggucugcca cgcccucugc ucccccgagg gcugcugggg ccccgagccc     1560

cgcgacugcg ucuccugccg caacgucucc cgcggccgcg agugcgucga caagugcaac     1620

cuccucgagg gcgagccccg cgaguucguc gagaacuccg agugcaucca gugccacccc     1680

gagugccucc cccaggccau gaacaucacc ugcaccggcc gcggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgucaaga ccugccccgc cggcgucaug     1800

ggcgagaaca acacccucgu cuggaaguac gccgacgccg gccacgucug ccaccucugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccucg agggcugccc caccaacggc     1920

uccuacaucg ucucccacuu cccccgcucc uucuacaaga uguccgucca c              1971


<210>  1347
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__EAW50963

<400>  1347
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagug ugucagggaa caucuaacaa gcugacucaa      120

cuagguacgu ucgaggacca cuuucucuca cugcagcgga uguucaauaa cugcgaaguc      180

guucuuggca aucuggagau caccuacgug cagcgcaacu augauuugag uuuucucaaa      240

acaauucagg aaguagccgg guacgugcug auagcucuga auacugucga gcgaauccca      300

cucgagaacu uacaaauuau ccguggaaau auguauuacg aaaacagcua ugcacuggcc      360

gugcuuucca auuacgacgc uaacaagacc ggcuugaaag agcugccgau gagaaaucua      420

caggaaauuc uccauggugc cguuagguuc ucuaacaauc ccgcgcugug uaacguggag      480

ucgauccagu ggcgggauau agucucaagc gacuuucuua guaauauguc cauggauuuc      540

cagaaccacc uggggucuug ccaaaagugu gacccuagcu gcccaaacgg auccuguugg      600

ggcgcaggcg aggaaaauug ccagaaguug acaaaaauca uuugugccca gcagugcuca      660

gggcgcugua gaggaaagag ucccagcgau ugcugccaua accaaugugc ugccgguugc      720

accggcccua gggagucuga cugucucgug ugccggaaau uucgcgauga agcaacuugu      780

aaggacacau gcccaccccu gauguuauau aauccuacca cguaccagau ggauguaaac      840

ccagagggga aauacuccuu cggagcuacu uguguuaaga agugcccgcg aaauuaugug      900

gucaccgacc acggcucaug ugugagagcc ugcggugcgg auagcuacga aauggaggag      960

gacgggguga ggaaauguaa gaaaugcgaa ggacccugcc ggaaggucug uaacggcauc     1020

ggcauugggg aguuuaaaga cagucugucu aucaaugcca caaacauaaa gcauuucaaa     1080

aauugcacuu ccauuagcgg agaucuccac auccuuccug uugcauuucg uggugacucg     1140

uucacccaca caccaccccu ggauccucag gaauuggaca uucuaaagac cgugaaggag     1200

aucacgggcu uucugcucau ccaggcuugg ccagaaaacc gcacugaucu gcaugccuuc     1260

gagaaucuug agauuauaag agggaggaca aaacaacacg gacaguucuc ucuggcugua     1320

guguccuuga acaucaccuc acucggccug cggaguuuaa aggaaauuag cgacggugau     1380

gucaucauau ccgggaauaa aaaccugugu uaugccaaua cuauuaacug gaagaaacua     1440

uuuggcacau cuggacagaa gaccaagauc aucagcaacc gaggcgaaaa uucaugcaaa     1500

gcaacggggc aaguguguca ugcccucugc agucccgaag gauguugggg uccggagccu     1560

cgcgacugcg uuuccuguag aaacgugagc aggggccggg aaugcgucga uaaguguaau     1620

cugcuugagg gggagccccg cgaguucgug gagaacucug aaugcauuca gugccaccca     1680

gaguguuugc cucaggcuau gaauauuacc ugcacaggaa gaggccccga caacuguauc     1740

cagugcgcgc acuacauaga ugguccacau uguguaaaaa cuugccccgc agggguuaug     1800

ggcgagaaua acacccuggu guggaaguau gccgacgcug gacacgucug ucaucucugc     1860

cacccuaauu guacauacgg cugcacuggg ccaggacugg aagguugucc gaccaacggc     1920

ucauauaucg ugagucauuu ucccaggagc uucuacaaaa uguccgucca c              1971


<210>  1348
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__EAW50963

<400>  1348
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cugggcaccu ucgaggacca cuuccugagc cugcagagaa uguucaacaa cugcgaggug      180

gugcugggca accuggagau caccuacgug cagagaaacu acgaccugag cuuccugaag      240

accauccagg agguggccgg cuacgugcug aucgcccuga acaccgugga gagaaucccc      300

cuggagaacc ugcagaucau cagaggcaac auguacuacg agaacagcua cgcccuggcc      360

gugcugagca acuacgacgc caacaagacc ggccugaagg agcugcccau gagaaaccug      420

caggagaucc ugcacggcgc cgugagauuc agcaacaacc ccgcccugug caacguggag      480

agcauccagu ggagagacau cgugagcagc gacuuccuga gcaacaugag cauggacuuc      540

cagaaccacc ugggcagcug ccagaagugc gaccccagcu gccccaacgg cagcugcugg      600

ggcgccggcg aggagaacug ccagaagcug accaagauca ucugcgccca gcagugcagc      660

ggcagaugca gaggcaagag ccccagcgac ugcugccaca accagugcgc cgccggcugc      720

accggcccca gagagagcga cugccuggug ugcagaaagu ucagagacga ggccaccugc      780

aaggacaccu gccccccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggca aguacagcuu cggcgccacc ugcgugaaga agugccccag aaacuacgug      900

gugaccgacc acggcagcug cgugagagcc ugcggcgccg acagcuacga gauggaggag      960

gacggcguga gaaagugcaa gaagugcgag ggccccugca gaaaggugug caacggcauc     1020

ggcaucggcg aguucaagga cagccugagc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucagcgg cgaccugcac auccugcccg uggccuucag aggcgacagc     1140

uucacccaca cccccccccu ggacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccugcugau ccaggccugg cccgagaaca gaaccgaccu gcacgccuuc     1260

gagaaccugg agaucaucag aggcagaacc aagcagcacg gccaguucag ccuggccgug     1320

gugagccuga acaucaccag ccugggccug agaagccuga aggagaucag cgacggcgac     1380

gugaucauca gcggcaacaa gaaccugugc uacgccaaca ccaucaacug gaagaagcug     1440

uucggcacca gcggccagaa gaccaagauc aucagcaaca gaggcgagaa cagcugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg gcugcugggg ccccgagccc     1560

agagacugcg ugagcugcag aaacgugagc agaggcagag agugcgugga caagugcaac     1620

cugcuggagg gcgagcccag agaguucgug gagaacagcg agugcaucca gugccacccc     1680

gagugccugc cccaggccau gaacaucacc ugcaccggca gaggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgugaug     1800

ggcgagaaca acacccuggu guggaaguac gccgacgccg gccacgugug ccaccugugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccugg agggcugccc caccaacggc     1920

agcuacaucg ugagccacuu ccccagaagc uucuacaaga ugagcgugca c              1971


<210>  1349
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__EAW50963

<400>  1349
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagug ugucagggaa caucuaacaa gcugacgcaa      120

cuuggcaccu ucgaggacca cuuucugagc cuccagcgca uguucaauaa cugcgaaguc      180

guucugggga aucuggagau cacauacgug cagagaaacu augaucucuc cuuucugaaa      240

accauucagg aaguggccgg auacguccuu aucgcucuga auacagugga gcggauuccg      300

cucgagaacc ugcaaaucau ucgcggcaau auguauuacg aaaacucuua ugcccuugcg      360

guucugagca auuacgacgc caacaagacc gggcucaaag agcugcccau gagaaaucug      420

caggaaaucc uccauggagc ugugcgguuc uccaacaauc cugcccugug uaacgucgag      480

ucuauccagu ggcgcgauau ugugagcucc gacuuucuua gcaauauguc uauggauuuc      540

cagaaccacc ugggcuccug ccaaaagugu gaccccagcu gcccuaacgg cucuuguugg      600

ggagcugggg aggaaaauug ccagaagcuc acaaaaauca uuugugccca gcagugcucc      660

ggcagauguc ggggaaagag ccccucugau ugcugccaua accaaugugc ggccgggugc      720

accggcccuc gcgaguccga cugucugguu ugcagaaaau uucgggauga agcuacgugu      780

aaggauaccu gcccgccccu uaugcuguau aauccuacaa ccuaccagau ggacgugaac      840

cccgagggga aauacagcuu cggagccaca ugugucaaga agugcccucg caauuaugug      900

gugaccgacc acggcuccug ugucagagcu ugcggcgccg auucuuacga aauggaggag      960

gacgggguuc ggaaauguaa gaaaugcgaa ggacccugcc gcaaggugug uaacggcauc     1020

gggauuggag aguuuaaaga cagccucucc aucaaugcca cgaacauuaa gcauuucaaa     1080

aauugcacaa gcaucucugg cgaucugcac auccugccgg uggcuuuuag aggggacucc     1140

uucacccaca caccuccccu cgauccucag gaacuggaca uucuuaagac cgucaaggag     1200

aucaccggau uucugcucau ucaagcgugg cccgaaaacc ggacagaucu gcaugccuuc     1260

gagaaucuug agaucauuag aggccgcacg aaacagcacg gccaguucag ccuggcugug     1320

guuucucuca acaucaccag ccuggggcug cggucccuca aggaaaucuc ugacggagau     1380

gugauuauca gcggcaauaa aaaccugugu uaugccaaua caauuaacug gaagaaacuu     1440

uuugggaccu ccggacagaa gacaaagauc auuagcaaca gaggcgaaaa uucuugcaaa     1500

gccaccgggc aagucuguca ugcucugugc ucccccgaag gcuguugggg accugagccg     1560

cgcgacugcg ugagcugucg gaacguuucu agaggccgcg aaugcgugga uaaguguaau     1620

cuccuggagg gggagccccg ggaguucguc gagaacuccg aaugcaucca gugccacccu     1680

gagugucugc cccaggccau gaauaucacg ugcacaggaa gaggcccuga caacuguauu     1740

cagugcgcgc acuacaucga ugggccccau ugugugaaaa ccugcccggc uggagucaug     1800

ggcgagaaua acacccuugu guggaaguau gccgacgccg ggcacguuug ucaucucugc     1860

cacccuaauu guacauacgg cugcaccgga cccggccugg aagggugucc uacaaacgga     1920

agcuauauug ugucccauuu uccccgcucu uucuacaaaa ugagcgucca c              1971


<210>  1350
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__E7BSV0

<400>  1350

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp 
        995                 1000                1005            


Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe 
    1010                1015                1020                


Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala 
1025                1030                1035                1040


Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln 
                1045                1050                1055    


Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp 
            1060                1065                1070        


Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro 
        1075                1080                1085            


Val Pro Gly Glu Trp Leu Val Trp Lys Gln Ser Cys Ser Ser Thr Ser 
    1090                1095                1100                


Ser Thr His Ser Ala Ala Ala Ser Leu Gln Cys Pro Ser Gln Val Leu 
1105                1110                1115                1120


Pro Pro Ala Ser Pro Glu Gly Glu Thr Val Ala Asp Leu Gln Thr Gln 
                1125                1130                1135    






<210>  1351
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__ADL28125

<400>  1351
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaguu ugccaaggca cgaguaacaa gcucacgcag      120

uugggcacuu uugaagauca uuuucucagc cuccagagga uguucaauaa cugugaggug      180

guccuuggga auuuggaaau uaccuaugug cagaggaauu augaucuuuc cuucuuaaag      240

accauccagg agguggcugg uuauguccuc auugcccuca acacagugga gcgaauuccu      300

uuggaaaacc ugcagaucau cagaggaaau auguacuacg aaaauuccua ugccuuagca      360

gucuuaucua acuaugaugc aaauaaaacc ggacugaagg agcugcccau gagaaauuua      420

caggaaaucc ugcauggcgc cgugcgguuc agcaacaacc cugcccugug caacguggag      480

agcauccagu ggcgggacau agucagcagu gacuuucuca gcaacauguc gauggacuuc      540

cagaaccacc ugggcagcug ccaaaagugu gauccaagcu gucccaaugg gagcugcugg      600

ggugcaggag aggagaacug ccagaaacug accaaaauca ucugugccca gcagugcucc      660

gggcgcugcc guggcaaguc ccccagugac ugcugccaca accagugugc ugcaggcugc      720

acaggccccc gggagagcga cugccugguc ugccgcaaau uccgagacga agccacgugc      780

aaggacaccu gccccccacu caugcucuac aaccccacca cguaccagau ggaugugaac      840

cccgagggca aauacagcuu uggugccacc ugcgugaaga aguguccccg uaauuaugug      900

gugacagauc acggcucgug cguccgagcc uguggggccg acagcuauga gauggaggaa      960

gacggcgucc gcaaguguaa gaagugcgaa gggccuugcc gcaaagugug uaacggaaua     1020

gguauuggug aauuuaaaga cucacucucc auaaaugcua cgaauauuaa acacuucaaa     1080

aacugcaccu ccaucagugg cgaucuccac auccugccgg uggcauuuag gggugacucc     1140

uucacacaua cuccuccucu ggauccacag gaacuggaua uucugaaaac cguaaaggaa     1200

aucacagggu uuuugcugau ucaggcuugg ccugaaaaca ggacggaccu ccaugccuuu     1260

gagaaccuag aaaucauacg cggcaggacc aagcaacaug gucaguuuuc ucuugcaguc     1320

gucagccuga acauaacauc cuugggauua cgcucccuca aggagauaag ugauggagau     1380

gugauaauuu caggaaacaa aaauuugugc uaugcaaaua caauaaacug gaaaaaacug     1440

uuugggaccu ccggucagaa aaccaaaauu auaagcaaca gaggugaaaa cagcugcaag     1500

gccacaggcc aggucugcca ugccuugugc ucccccgagg gcugcugggg cccggagccc     1560

agggacugcg ucucuugccg gaaugucagc cgaggcaggg aaugcgugga caagugcaac     1620

cuucuggagg gugagccaag ggaguuugug gagaacucug agugcauaca gugccaccca     1680

gagugccugc cucaggccau gaacaucacc ugcacaggac ggggaccaga caacuguauc     1740

cagugugccc acuacauuga cggcccccac ugcgucaaga ccugcccggc aggagucaug     1800

ggagaaaaca acacccuggu cuggaaguac gcagacgccg gccaugugug ccaccugugc     1860

cauccaaacu gcaccuacgg augcacuggg ccaggucuug aaggcugucc aacgaauggg     1920

ccuaagaucc cguccaucgc cacugggaug gugggggccc uccucuugcu gcugguggug     1980

gcccugggga ucggccucuu caugcgaagg cgccacaucg uucggaagcg cacgcugcgg     2040

aggcugcugc aggagaggga gcuuguggag ccucuuacac ccaguggaga agcucccaac     2100

caagcucucu ugaggaucuu gaaggaaacu gaauucaaaa agaucaaagu gcugggcucc     2160

ggugcguucg gcacggugua uaagggacuc uggaucccag aaggugagaa aguuaaaauu     2220

cccgucgcua ucaaggaauu aagagaagca acaucuccga aagccaacaa ggaaauccuc     2280

gaugaagccu acgugauggc cagcguggac aacccccacg ugugccgccu gcugggcauc     2340

ugccucaccu ccaccgugca gcucaucacg cagcucaugc ccuucggcug ccuccuggac     2400

uauguccggg aacacaaaga caauauuggc ucccaguacc ugcucaacug gugugugcag     2460

aucgcaaagg gcaugaacua cuuggaggac cgucgcuugg ugcaccgcga ccuggcagcc     2520

aggaacguac uggugaaaac accgcagcau gucaagauca cagauuuugg gcuggccaaa     2580

cugcugggug cggaagagaa agaauaccau gcagaaggag gcaaagugcc uaucaagugg     2640

auggcauugg aaucaauuuu acacagaauc uauacccacc agagugaugu cuggagcuac     2700

ggggugaccg uuugggaguu gaugaccuuu ggauccaagc cauaugacgg aaucccugcc     2760

agcgagaucu ccuccauccu ggagaaagga gaacgccucc cucagccacc cauauguacc     2820

aucgaugucu acaugaucau ggucaagugc uggaugauag acgcagauag ucgcccaaag     2880

uuccgugagu ugaucaucga auucuccaaa auggcccgag acccccagcg cuaccuuguc     2940

auucaggggg augaaagaau gcauuugcca aguccuacag acuccaacuu cuaccgugcc     3000

cugauggaug aagaagacau ggacgacgug guggaugccg acgaguaccu caucccacag     3060

cagggcuucu ucagcagccc cuccacguca cggacucccc uccugagcuc ucugagugca     3120

accagcaaca auuccaccgu ggcuugcauu gauagaaaug ggcugcaaag cugucccauc     3180

aaggaagaca gcuucuugca gcgauacagc ucagacccca caggcgccuu gacugaggac     3240

agcauagacg acaccuuccu cccagugccu ggugaguggc uugucuggaa acaguccugc     3300

uccucaaccu ccucgaccca cucagcagca gccagucucc aguguccaag ccaggugcuc     3360

ccuccagcau cuccagaggg ggaaacagug gcagauuugc agacacagug a              3411


<210>  1352
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__ADL28125

<400>  1352
augcgcccca gcggcaccgc cggggccgcg cugcucgccc ugcuggccgc ccucugcccg       60

gccucccggg cgcuggagga gaagaaggug ugccagggca ccagcaacaa gcugacgcag      120

cucgggaccu ucgaggacca cuuccugucc cugcagcgca uguucaacaa cugcgagguc      180

gugcucggca accuggagau caccuacgug cagcggaacu acgaccugag cuuccucaag      240

accauccagg aggucgccgg guacgugcug aucgcccuga acacggugga gcgcaucccc      300

cucgagaacc ugcagaucau ccggggcaac auguacuacg agaacuccua cgcccuggcg      360

guccucagca acuacgacgc caacaagacc ggccugaagg agcugcccau gcgcaaccuc      420

caggagaucc ugcacggggc cgugcgguuc uccaacaacc ccgcccugug caacguggag      480

agcauccagu ggcgcgacau cgucuccagc gacuuccucu ccaacaugag cauggacuuc      540

cagaaccacc ugggcuccug ccagaagugc gacccgagcu gccccaacgg guccugcugg      600

ggcgccgggg aggagaacug ccagaagcug accaagauca ucugcgcgca gcagugcagc      660

ggccggugcc gcggcaaguc ccccagcgac ugcugccaca accagugcgc cgccgggugc      720

accggccccc gggaguccga cugccucgug ugccgcaagu uccgggacga ggccacgugc      780

aaggacacgu gcccgccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggga aguacagcuu cggcgcgacc ugcgucaaga agugcccgcg caacuacgug      900

gugaccgacc acggcagcug cguccgggcc ugcggggccg acuccuacga gauggaggag      960

gacggcgugc gcaagugcaa gaagugcgag gggcccugcc ggaaggugug caacggcauc     1020

gggaucggcg aguucaagga cagccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucuccgg cgaccugcac auccugcccg ucgccuuccg cggggacagc     1140

uucacgcaca cgcccccgcu cgacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccuccugau ccaggccugg cccgagaacc ggaccgaccu gcacgcguuc     1260

gagaaccucg agaucauccg cgggcggacc aagcagcacg gccaguucuc ccuggccgug     1320

gucagccuga acaucaccuc ccucgggcug cgcagccuga aggagaucuc cgacggcgac     1380

gugaucauca gcggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcug     1440

uucgggacgu ccggccagaa gaccaagauc aucagcaacc gcggggagaa cuccugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg ggugcugggg cccggagccc     1560

cgggacugcg ucuccugccg caacgugagc cggggccgcg agugcgucga caagugcaac     1620

cuccuggagg gggagccccg ggaguucgug gagaacuccg agugcaucca gugccacccc     1680

gagugccugc cgcaggcgau gaacaucacg ugcaccggcc gcgggcccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgucaug     1800

ggggagaaca acacccuggu guggaaguac gccgacgcgg gccacgugug ccaccucugc     1860

cacccgaacu gcaccuacgg gugcacgggc cccgggcugg agggcugccc caccaacggc     1920

ccgaagaucc ccagcaucgc caccgggaug gucggcgccc ugcuccugcu gcucguggug     1980

gcccugggga ucggccuguu caugcggcgc cggcacaucg uccgcaagcg gacccuccgc     2040

cggcugcugc aggagcgcga gcucguggag ccccugacgc ccagcgggga ggccccgaac     2100

caggcgcugc uccggauccu gaaggagacc gaguucaaga agaucaaggu gcugggcucc     2160

ggcgccuucg ggaccgucua caagggccuc uggauccccg agggggagaa ggugaagauc     2220

cccguggcca ucaaggagcu gcgcgaggcc accagcccca aggccaacaa ggagauccug     2280

gacgaggcgu acgucauggc cuccguggac aacccgcacg ugugccggcu ccugggcauc     2340

ugccugacca gcacggucca gcucaucacc cagcugaugc ccuucgggug ccugcucgac     2400

uacgugcgcg agcacaagga caacaucggc ucccaguacc ugcugaacug gugcgugcag     2460

aucgccaagg gcaugaacua ccucgaggac cggcgccugg uccaccgcga ccuggccgcc     2520

cggaacgugc ucgugaagac gccccagcac gucaagauca ccgacuucgg gcuggcgaag     2580

cugcucggcg ccgaggagaa ggaguaccac gccgagggcg ggaaggugcc caucaagugg     2640

auggcccugg agagcauccu gcaccgcauc uacacccacc aguccgacgu guggagcuac     2700

ggggucaccg ugugggagcu caugaccuuc ggcuccaagc cguacgacgg cauccccgcg     2760

agcgagaucu ccagcauccu ggagaagggg gagcggcugc cccagccccc gaucugcacc     2820

aucgacgugu acaugaucau ggucaagugc uggaugaucg acgccgacuc ccgccccaag     2880

uuccgggagc ucaucaucga guucagcaag auggcccgcg acccccagcg guaccuggug     2940

auccagggcg acgagcgcau gcaccucccc uccccgacgg acagcaacuu cuaccgggcc     3000

cugauggacg aggaggacau ggacgacgug gucgacgccg acgaguaccu gaucccccag     3060

cagggguucu ucuccagccc cagcaccucc cgcacgcccc ugcucagcuc ccugagcgcg     3120

accuccaaca acagcaccgu ggccugcauc gaccggaacg gccugcaguc cugcccgauc     3180

aaggaggaca gcuuccucca gcgcuacucc agcgacccca ccggcgcccu gaccgaggac     3240

uccaucgacg acaccuuccu gcccgugccg ggggaguggc ucgucuggaa gcagagcugc     3300

uccagcacgu ccagcaccca cuccgccgcc gcgagccugc agugccccuc ccaggugcug     3360

ccgcccgcca gccccgaggg cgagaccgug gccgaccucc agacccagug a              3411


<210>  1353
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__ADL28125

<400>  1353
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagguc ugccagggca ccuccaacaa gcucacccag      120

cucggcaccu ucgaggacca cuuccucucc cuccagcgca uguucaacaa cugcgagguc      180

guccucggca accucgagau caccuacguc cagcgcaacu acgaccucuc cuuccucaag      240

accauccagg aggucgccgg cuacguccuc aucgcccuca acaccgucga gcgcaucccc      300

cucgagaacc uccagaucau ccgcggcaac auguacuacg agaacuccua cgcccucgcc      360

guccucucca acuacgacgc caacaagacc ggccucaagg agcuccccau gcgcaaccuc      420

caggagaucc uccacggcgc cguccgcuuc uccaacaacc ccgcccucug caacgucgag      480

uccauccagu ggcgcgacau cgucuccucc gacuuccucu ccaacauguc cauggacuuc      540

cagaaccacc ucggcuccug ccagaagugc gaccccuccu gccccaacgg cuccugcugg      600

ggcgccggcg aggagaacug ccagaagcuc accaagauca ucugcgccca gcagugcucc      660

ggccgcugcc gcggcaaguc ccccuccgac ugcugccaca accagugcgc cgccggcugc      720

accggccccc gcgaguccga cugccucguc ugccgcaagu uccgcgacga ggccaccugc      780

aaggacaccu gccccccccu caugcucuac aaccccacca ccuaccagau ggacgucaac      840

cccgagggca aguacuccuu cggcgccacc ugcgucaaga agugcccccg caacuacguc      900

gucaccgacc acggcuccug cguccgcgcc ugcggcgccg acuccuacga gauggaggag      960

gacggcgucc gcaagugcaa gaagugcgag ggccccugcc gcaaggucug caacggcauc     1020

ggcaucggcg aguucaagga cucccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcaccu ccaucuccgg cgaccuccac auccuccccg ucgccuuccg cggcgacucc     1140

uucacccaca cccccccccu cgacccccag gagcucgaca uccucaagac cgucaaggag     1200

aucaccggcu uccuccucau ccaggccugg cccgagaacc gcaccgaccu ccacgccuuc     1260

gagaaccucg agaucauccg cggccgcacc aagcagcacg gccaguucuc ccucgccguc     1320

gucucccuca acaucaccuc ccucggccuc cgcucccuca aggagaucuc cgacggcgac     1380

gucaucaucu ccggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcuc     1440

uucggcaccu ccggccagaa gaccaagauc aucuccaacc gcggcgagaa cuccugcaag     1500

gccaccggcc aggucugcca cgcccucugc ucccccgagg gcugcugggg ccccgagccc     1560

cgcgacugcg ucuccugccg caacgucucc cgcggccgcg agugcgucga caagugcaac     1620

cuccucgagg gcgagccccg cgaguucguc gagaacuccg agugcaucca gugccacccc     1680

gagugccucc cccaggccau gaacaucacc ugcaccggcc gcggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgucaaga ccugccccgc cggcgucaug     1800

ggcgagaaca acacccucgu cuggaaguac gccgacgccg gccacgucug ccaccucugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccucg agggcugccc caccaacggc     1920

cccaagaucc ccuccaucgc caccggcaug gucggcgccc uccuccuccu ccucgucguc     1980

gcccucggca ucggccucuu caugcgccgc cgccacaucg uccgcaagcg cacccuccgc     2040

cgccuccucc aggagcgcga gcucgucgag ccccucaccc ccuccggcga ggcccccaac     2100

caggcccucc uccgcauccu caaggagacc gaguucaaga agaucaaggu ccucggcucc     2160

ggcgccuucg gcaccgucua caagggccuc uggauccccg agggcgagaa ggucaagauc     2220

cccgucgcca ucaaggagcu ccgcgaggcc accuccccca aggccaacaa ggagauccuc     2280

gacgaggccu acgucauggc cuccgucgac aacccccacg ucugccgccu ccucggcauc     2340

ugccucaccu ccaccgucca gcucaucacc cagcucaugc ccuucggcug ccuccucgac     2400

uacguccgcg agcacaagga caacaucggc ucccaguacc uccucaacug gugcguccag     2460

aucgccaagg gcaugaacua ccucgaggac cgccgccucg uccaccgcga ccucgccgcc     2520

cgcaacgucc ucgucaagac cccccagcac gucaagauca ccgacuucgg ccucgccaag     2580

cuccucggcg ccgaggagaa ggaguaccac gccgagggcg gcaagguccc caucaagugg     2640

auggcccucg aguccauccu ccaccgcauc uacacccacc aguccgacgu cugguccuac     2700

ggcgucaccg ucugggagcu caugaccuuc ggcuccaagc ccuacgacgg cauccccgcc     2760

uccgagaucu ccuccauccu cgagaagggc gagcgccucc cccagccccc caucugcacc     2820

aucgacgucu acaugaucau ggucaagugc uggaugaucg acgccgacuc ccgccccaag     2880

uuccgcgagc ucaucaucga guucuccaag auggcccgcg acccccagcg cuaccucguc     2940

auccagggcg acgagcgcau gcaccucccc ucccccaccg acuccaacuu cuaccgcgcc     3000

cucauggacg aggaggacau ggacgacguc gucgacgccg acgaguaccu caucccccag     3060

cagggcuucu ucuccucccc cuccaccucc cgcacccccc uccucuccuc ccucuccgcc     3120

accuccaaca acuccaccgu cgccugcauc gaccgcaacg gccuccaguc cugccccauc     3180

aaggaggacu ccuuccucca gcgcuacucc uccgacccca ccggcgcccu caccgaggac     3240

uccaucgacg acaccuuccu ccccgucccc ggcgaguggc ucgucuggaa gcaguccugc     3300

uccuccaccu ccuccaccca cuccgccgcc gccucccucc agugccccuc ccagguccuc     3360

ccccccgccu cccccgaggg cgagaccguc gccgaccucc agacccagug a              3411


<210>  1354
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__ADL28125

<400>  1354
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagug ugucagggaa caucuaacaa gcugacucaa      120

cuagguacgu ucgaggacca cuuucucuca cugcagcgga uguucaauaa cugcgaaguc      180

guucuuggca aucuggagau caccuacgug cagcgcaacu augauuugag uuuucucaaa      240

acaauucagg aaguagccgg guacgugcug auagcucuga auacugucga gcgaauccca      300

cucgagaacu uacaaauuau ccguggaaau auguauuacg aaaacagcua ugcacuggcc      360

gugcuuucca auuacgacgc uaacaagacc ggcuugaaag agcugccgau gagaaaucua      420

caggaaauuc uccauggugc cguuagguuc ucuaacaauc ccgcgcugug uaacguggag      480

ucgauccagu ggcgggauau agucucaagc gacuuucuua guaauauguc cauggauuuc      540

cagaaccacc uggggucuug ccaaaagugu gacccuagcu gcccaaacgg auccuguugg      600

ggcgcaggcg aggaaaauug ccagaaguug acaaaaauca uuugugccca gcagugcuca      660

gggcgcugua gaggaaagag ucccagcgau ugcugccaua accaaugugc ugccgguugc      720

accggcccua gggagucuga cugucucgug ugccggaaau uucgcgauga agcaacuugu      780

aaggacacau gcccaccccu gauguuauau aauccuacca cguaccagau ggauguaaac      840

ccagagggga aauacuccuu cggagcuacu uguguuaaga agugcccgcg aaauuaugug      900

gucaccgacc acggcucaug ugugagagcc ugcggugcgg auagcuacga aauggaggag      960

gacgggguga ggaaauguaa gaaaugcgaa ggacccugcc ggaaggucug uaacggcauc     1020

ggcauugggg aguuuaaaga cagucugucu aucaaugcca caaacauaaa gcauuucaaa     1080

aauugcacuu ccauuagcgg agaucuccac auccuuccug uugcauuucg uggugacucg     1140

uucacccaca caccaccccu ggauccucag gaauuggaca uucuaaagac cgugaaggag     1200

aucacgggcu uucugcucau ccaggcuugg ccagaaaacc gcacugaucu gcaugccuuc     1260

gagaaucuug agauuauaag agggaggaca aaacaacacg gacaguucuc ucuggcugua     1320

guguccuuga acaucaccuc acucggccug cggaguuuaa aggaaauuag cgacggugau     1380

gucaucauau ccgggaauaa aaaccugugu uaugccaaua cuauuaacug gaagaaacua     1440

uuuggcacau cuggacagaa gaccaagauc aucagcaacc gaggcgaaaa uucaugcaaa     1500

gcaacggggc aaguguguca ugcccucugc agucccgaag gauguugggg uccggagccu     1560

cgcgacugcg uuuccuguag aaacgugagc aggggccggg aaugcgucga uaaguguaau     1620

cugcuugagg gggagccccg cgaguucgug gagaacucug aaugcauuca gugccaccca     1680

gaguguuugc cucaggcuau gaauauuacc ugcacaggaa gaggccccga caacuguauu     1740

cagugcgcgc acuacauaga ugguccacau uguguaaaaa cuugccccgc agggguuaug     1800

ggcgagaaua acacccuggu guggaaguau gccgacgcug gacacgucug ucaucucugc     1860

cacccuaauu guacauacgg cugcacuggg ccaggacugg aagguugucc gaccaacggc     1920

cccaaaaucc cuucaauugc cacagggaug gugggagcac uucuguugcu ccuggucgug     1980

gccuuaggca ucggucuguu uaugaggcgu cggcauaucg uucgaaagag aacccuaagg     2040

cgccuccugc aagagcggga acuuguggag ccauugacuc ccagugggga agcuccuaau     2100

caggcccugc ucagaauccu gaaggagacg gaguucaaaa agauaaaagu auuaggcagc     2160

ggagcauuug gcacagucua uaaggggcug uggaucccag aaggagagaa agugaagauu     2220

cccguugcga ucaaggaacu uagggaggcu accuccccga aagccaacaa ggaaauuuug     2280

gacgaggcau acgugauggc cucugucgau aauccucacg ugugccgccu ccugggcauc     2340

ugccuaacuu cgaccguaca gcugauaaca cagcucaugc cauucgguug ucugcuugac     2400

uacgugcgag agcacaaaga uaacaucggg agccaauauu ugcugaauug gugcguucag     2460

auugcuaagg gaaugaacua cuuagaagac cggcgucucg uccauagaga ucuggccgca     2520

aggaacgugc uugugaaaac uccccagcac gucaagauca ccgacuuugg ccuggcuaaa     2580

uugcucggug ccgaggaaaa ggaguaucau gcggaaggcg ggaagguucc uauuaaaugg     2640

auggcccugg aguccauccu acaccgcaua uacacacacc agucagaugu guggaguuau     2700

ggagugacgg uaugggagcu gaugaccuuc ggcucuaagc ccuacgacgg gauuccagcu     2760

agcgaaaucu ccucaauucu cgagaaagga gaacggcugc cucaaccccc aaucuguacu     2820

auagaugucu auaugaucau ggugaagugc uggaugauug acgcagauag cagaccgaaa     2880

uuuagggagc uuaucauuga guucucuaag auggcccgag acccucagcg cuacuugguu     2940

auccagggcg augaacggau gcaucugccc uccccaacag acaguaauuu uuacagagcu     3000

uuaauggacg aggaagauau ggacgaugug gucgacgccg augaguaucu cauaccccaa     3060

caggguuucu uuagcucucc uuccaccuca aggacaccac ugcuuaguag ccugucggca     3120

acuuccaaca auucuaccgu ggcguguauu gaccguaacg ggcuacagag cugccccauc     3180

aaggaagauu cauuccucca gcgcuacagu uccgacccua cgggagcccu gaccgaggau     3240

ucuaucgacg auacauucuu gccgguucca ggcgaguggc ugguguggaa acaaagcugu     3300

uccucaacua gcaguaccca cucugcugcc gcauccuuac agugccccag ccagguacuc     3360

ccuccagcuu cgcccgaagg ugagacaguc gccgaccugc agacucaaug a              3411


<210>  1355
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__ADL28125

<400>  1355
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cugggcaccu ucgaggacca cuuccugagc cugcagagaa uguucaacaa cugcgaggug      180

gugcugggca accuggagau caccuacgug cagagaaacu acgaccugag cuuccugaag      240

accauccagg agguggccgg cuacgugcug aucgcccuga acaccgugga gagaaucccc      300

cuggagaacc ugcagaucau cagaggcaac auguacuacg agaacagcua cgcccuggcc      360

gugcugagca acuacgacgc caacaagacc ggccugaagg agcugcccau gagaaaccug      420

caggagaucc ugcacggcgc cgugagauuc agcaacaacc ccgcccugug caacguggag      480

agcauccagu ggagagacau cgugagcagc gacuuccuga gcaacaugag cauggacuuc      540

cagaaccacc ugggcagcug ccagaagugc gaccccagcu gccccaacgg cagcugcugg      600

ggcgccggcg aggagaacug ccagaagcug accaagauca ucugcgccca gcagugcagc      660

ggcagaugca gaggcaagag ccccagcgac ugcugccaca accagugcgc cgccggcugc      720

accggcccca gagagagcga cugccuggug ugcagaaagu ucagagacga ggccaccugc      780

aaggacaccu gccccccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggca aguacagcuu cggcgccacc ugcgugaaga agugccccag aaacuacgug      900

gugaccgacc acggcagcug cgugagagcc ugcggcgccg acagcuacga gauggaggag      960

gacggcguga gaaagugcaa gaagugcgag ggccccugca gaaaggugug caacggcauc     1020

ggcaucggcg aguucaagga cagccugagc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucagcgg cgaccugcac auccugcccg uggccuucag aggcgacagc     1140

uucacccaca cccccccccu ggacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccugcugau ccaggccugg cccgagaaca gaaccgaccu gcacgccuuc     1260

gagaaccugg agaucaucag aggcagaacc aagcagcacg gccaguucag ccuggccgug     1320

gugagccuga acaucaccag ccugggccug agaagccuga aggagaucag cgacggcgac     1380

gugaucauca gcggcaacaa gaaccugugc uacgccaaca ccaucaacug gaagaagcug     1440

uucggcacca gcggccagaa gaccaagauc aucagcaaca gaggcgagaa cagcugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg gcugcugggg ccccgagccc     1560

agagacugcg ugagcugcag aaacgugagc agaggcagag agugcgugga caagugcaac     1620

cugcuggagg gcgagcccag agaguucgug gagaacagcg agugcaucca gugccacccc     1680

gagugccugc cccaggccau gaacaucacc ugcaccggca gaggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgugaug     1800

ggcgagaaca acacccuggu guggaaguac gccgacgccg gccacgugug ccaccugugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccugg agggcugccc caccaacggc     1920

cccaagaucc ccagcaucgc caccggcaug gugggcgccc ugcugcugcu gcugguggug     1980

gcccugggca ucggccuguu caugagaaga agacacaucg ugagaaagag aacccugaga     2040

agacugcugc aggagagaga gcugguggag ccccugaccc ccagcggcga ggcccccaac     2100

caggcccugc ugagaauccu gaaggagacc gaguucaaga agaucaaggu gcugggcagc     2160

ggcgccuucg gcaccgugua caagggccug uggauccccg agggcgagaa ggugaagauc     2220

cccguggcca ucaaggagcu gagagaggcc accagcccca aggccaacaa ggagauccug     2280

gacgaggccu acgugauggc cagcguggac aacccccacg ugugcagacu gcugggcauc     2340

ugccugacca gcaccgugca gcugaucacc cagcugaugc ccuucggcug ccugcuggac     2400

uacgugagag agcacaagga caacaucggc agccaguacc ugcugaacug gugcgugcag     2460

aucgccaagg gcaugaacua ccuggaggac agaagacugg ugcacagaga ccuggccgcc     2520

agaaacgugc uggugaagac cccccagcac gugaagauca ccgacuucgg ccuggccaag     2580

cugcugggcg ccgaggagaa ggaguaccac gccgagggcg gcaaggugcc caucaagugg     2640

auggcccugg agagcauccu gcacagaauc uacacccacc agagcgacgu guggagcuac     2700

ggcgugaccg ugugggagcu gaugaccuuc ggcagcaagc ccuacgacgg cauccccgcc     2760

agcgagauca gcagcauccu ggagaagggc gagagacugc cccagccccc caucugcacc     2820

aucgacgugu acaugaucau ggugaagugc uggaugaucg acgccgacag cagacccaag     2880

uucagagagc ugaucaucga guucagcaag auggccagag acccccagag auaccuggug     2940

auccagggcg acgagagaau gcaccugccc agccccaccg acagcaacuu cuacagagcc     3000

cugauggacg aggaggacau ggacgacgug guggacgccg acgaguaccu gaucccccag     3060

cagggcuucu ucagcagccc cagcaccagc agaacccccc ugcugagcag ccugagcgcc     3120

accagcaaca acagcaccgu ggccugcauc gacagaaacg gccugcagag cugccccauc     3180

aaggaggaca gcuuccugca gagauacagc agcgacccca ccggcgcccu gaccgaggac     3240

agcaucgacg acaccuuccu gcccgugccc ggcgaguggc ugguguggaa gcagagcugc     3300

agcagcacca gcagcaccca cagcgccgcc gccagccugc agugccccag ccaggugcug     3360

ccccccgcca gccccgaggg cgagaccgug gccgaccugc agacccagug a              3411


<210>  1356
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__ADL28125

<400>  1356
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagug ugucagggaa caucuaacaa gcugacgcaa      120

cuuggcaccu ucgaggacca cuuucugagc cuccagcgca uguucaauaa cugcgaaguc      180

guucugggga aucuggagau cacauacgug cagagaaacu augaucucuc cuuucugaaa      240

accauucagg aaguggccgg auacguccuu aucgcucuga auacagugga gcggauuccg      300

cucgagaacc ugcaaaucau ucgcggcaau auguauuacg aaaacucuua ugcccuugcg      360

guucugagca auuacgacgc caacaagacc gggcucaaag agcugcccau gagaaaucug      420

caggaaaucc uccauggagc ugugcgguuc uccaacaauc cugcccugug uaacgucgag      480

ucuauccagu ggcgcgauau ugugagcucc gacuuucuua gcaauauguc uauggauuuc      540

cagaaccacc ugggcuccug ccaaaagugu gaccccagcu gcccuaacgg cucuuguugg      600

ggagcugggg aggaaaauug ccagaagcuc acaaaaauca uuugugccca gcagugcucc      660

ggcagauguc ggggaaagag ccccucugau ugcugccaua accaaugugc ggccgggugc      720

accggcccuc gcgaguccga cugucugguu ugcagaaaau uucgggauga agcuacgugu      780

aaggauaccu gcccgccccu uaugcuguau aauccuacaa ccuaccagau ggacgugaac      840

cccgagggga aauacagcuu cggagccaca ugugucaaga agugcccucg caauuaugug      900

gugaccgacc acggcuccug ugucagagcu ugcggcgccg auucuuacga aauggaggag      960

gacgggguuc ggaaauguaa gaaaugcgaa ggacccugcc gcaaggugug uaacggcauc     1020

gggauuggag aguuuaaaga cagccucucc aucaaugcca cgaacauuaa gcauuucaaa     1080

aauugcacaa gcaucucugg cgaucugcac auccugccgg uggcuuuuag aggggacucc     1140

uucacccaca caccuccccu cgauccucag gaacuggaca uucuuaagac cgucaaggag     1200

aucaccggau uucugcucau ucaagcgugg cccgaaaacc ggacagaucu gcaugccuuc     1260

gagaaucuug agaucauuag aggccgcacg aaacagcacg gccaguucag ccuggcugug     1320

guuucucuca acaucaccag ccuggggcug cggucccuca aggaaaucuc ugacggagau     1380

gugauuauca gcggcaauaa aaaccugugu uaugccaaua caauuaacug gaagaaacuu     1440

uuugggaccu ccggacagaa gacaaagauc auuagcaaca gaggcgaaaa uucuugcaaa     1500

gccaccgggc aagucuguca ugcucugugc ucccccgaag gcuguugggg accugagccg     1560

cgcgacugcg ugagcugucg gaacguuucu agaggccgcg aaugcgugga uaaguguaau     1620

cuccuggagg gggagccccg ggaguucguc gagaacuccg aaugcaucca gugccacccu     1680

gagugucugc cccaggccau gaauaucacg ugcacaggaa gaggcccuga caacuguauu     1740

cagugcgcgc acuacaucga ugggccccau ugugugaaaa ccugcccggc uggagucaug     1800

ggcgagaaua acacccuugu guggaaguau gccgacgccg ggcacguuug ucaucucugc     1860

cacccuaauu guacauacgg cugcaccgga cccggccugg aagggugucc uacaaacgga     1920

cccaaaauuc cuagcaucgc uacgggcaug gugggggccc ugcuccugcu ucuggucgug     1980

gcucucggaa uuggccuguu uaugcgccgg agacauaucg uucgcaagcg gacccugaga     2040

cggcuucucc aagagcgcga acugguggag ccccugacac cguccgggga agccccuaau     2100

caggcgcucc ugcggauucu uaaggagacc gaguucaaaa agaucaaagu ccugggcucu     2160

ggagccuuug gcacagugua uaaggggcuc uggauccccg aaggagagaa agugaagauu     2220

cccguugcua ucaaggaacu gagagaggcc accagcccua aagcuaacaa ggaaauucug     2280

gacgaggccu acgucauggc guccguggau aauccgcacg ugugcagacu ucucggcauc     2340

ugccugacgu cuaccgucca gcugauuaca cagcucaugc ccuucgggug ucugcuugac     2400

uacgugcgcg agcacaaaga uaacaucgga agccaauauc ugcucaauug gugcguucag     2460

aucgccaagg gcaugaacua ccuggaagac cggagacugg ugcaucgcga ucuugcugcc     2520

agaaacgucc ucgugaaaac cccucagcac guuaagauua cagacuuugg gcuggcuaaa     2580

cugcucggcg ccgaggaaaa ggaguaucau gccgaaggag gcaaggugcc caucaaaugg     2640

auggcucugg aguccauucu ucaccggauc uacacccacc agagcgaugu cuggucuuau     2700

ggggugacgg uuugggagcu gaugacauuc ggauccaagc cuuacgacgg cauucccgcg     2760

agcgaaaucu cuuccauccu cgagaaaggg gaacgccugc cucaaccccc gauuuguacc     2820

aucgaugugu auaugauuau ggucaagugc uggaugaucg acgccgauag cagaccuaaa     2880

uuucgggagc ugauuaucga guucucuaag auggcucgcg acccccagag auaccuugug     2940

auccagggag augaacggau gcaucugccu agccccacag acuccaauuu uuaccgcgcc     3000

cucauggacg aggaagauau ggacgaugug gucgacgccg augaguaucu gauuccgcaa     3060

cagggcuucu uuagcucucc uuccaccagc agaacacccc uccuguccuc ucuuagcgcu     3120

accuccaaca auucuacggu ugccuguauc gaccggaacg gccugcagag cugcccuauu     3180

aaggaagauu ccuuccucca gcgcuacucu agcgacccca ccggggcgcu gacagaggau     3240

uccaucgacg auaccuuccu gcccgugccu ggagaguggc uuguguggaa acaaagcugu     3300

ucuuccacaa gcucuaccca cuccgcugcc gccagccugc agugcccguc ucagguccug     3360

cccccugcuu cccccgaagg cgagacggug gccgaccucc agacacaaug a              3411


<210>  1357
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__L0R6G1

<400>  1357

Met Cys Ala Thr Cys Ala Ile Gln Thr Ala Pro Thr Gly Pro Asn Lys 
1               5                   10                  15      


Ser Ser Leu Ser Asp Phe Ser Leu Pro Leu Lys Leu His Phe Leu Ser 
            20                  25                  30          


Thr Ile Ser Ile Ser Pro Phe Ala Ser Asn Lys Val Leu Thr Leu Phe 
        35                  40                  45              


Ile 
    


<210>  1358
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__CCO13722

<400>  1358
augugugcca ccugugccau ccaaacugca ccuacggguc cuaauaaauc uucacugucu       60

gacuuuaguc ucccacuaaa acugcauuuc cuuucuacaa uuucaauuuc ucccuuugcu      120

ucaaauaaag uccugacacu auucauuuga                                       150


<210>  1359
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__CCO13722

<400>  1359
augugcgcga ccugcgccau ccagaccgcc cccacgggcc cgaacaagag cucccugagc       60

gacuucuccc ucccccugaa gcugcacuuc cucagcacca ucuccaucag ccccuucgcc      120

uccaacaagg ugcugacccu guucaucuga                                       150


<210>  1360
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__CCO13722

<400>  1360
augugcgcca ccugcgccau ccagaccgcc cccaccggcc ccaacaaguc cucccucucc       60

gacuucuccc ucccccucaa gcuccacuuc cucuccacca ucuccaucuc ccccuucgcc      120

uccaacaagg uccucacccu cuucaucuga                                       150


<210>  1361
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__CCO13722

<400>  1361
augugcgcca ccugugcuau ccagacagca cccacuggcc cuaacaagag cucccugucu       60

gacuucucac ucccacuuaa acugcacuuu uugaguacga uuagcauauc cccguucgcc      120

ucuaauaagg uguuaacccu guuuaucuga                                       150


<210>  1362
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__CCO13722

<400>  1362
augugcgcca ccugcgccau ccagaccgcc cccaccggcc ccaacaagag cagccugagc       60

gacuucagcc ugccccugaa gcugcacuuc cugagcacca ucagcaucag ccccuucgcc      120

agcaacaagg ugcugacccu guucaucuga                                       150


<210>  1363
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__CCO13722

<400>  1363
augugcgcca ccugugcuau ccagacagcc cccacgggcc cuaacaagag cucccugucu       60

gacuucagcc ucccgcugaa acuucacuuu cuguccacca uuucuaucag ccccuucgcg      120

uccaauaagg ugcucacacu guuuauuuga                                       150


<210>  1364
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__P00533-2

<400>  1364

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  1365
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__CCDS47587.1

<400>  1365
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaguu ugccaaggca cgaguaacaa gcucacgcag      120

uugggcacuu uugaagauca uuuucucagc cuccagagga uguucaauaa cugugaggug      180

guccuuggga auuuggaaau uaccuaugug cagaggaauu augaucuuuc cuucuuaaag      240

accauccagg agguggcugg uuauguccuc auugcccuca acacagugga gcgaauuccu      300

uuggaaaacc ugcagaucau cagaggaaau auguacuacg aaaauuccua ugccuuagca      360

gucuuaucua acuaugaugc aaauaaaacc ggacugaagg agcugcccau gagaaauuua      420

caggaaaucc ugcauggcgc cgugcgguuc agcaacaacc cugcccugug caacguggag      480

agcauccagu ggcgggacau agucagcagu gacuuucuca gcaacauguc gauggacuuc      540

cagaaccacc ugggcagcug ccaaaagugu gauccaagcu gucccaaugg gagcugcugg      600

ggugcaggag aggagaacug ccagaaacug accaaaauca ucugugccca gcagugcucc      660

gggcgcugcc guggcaaguc ccccagugac ugcugccaca accagugugc ugcaggcugc      720

acaggccccc gggagagcga cugccugguc ugccgcaaau uccgagacga agccacgugc      780

aaggacaccu gccccccacu caugcucuac aaccccacca cguaccagau ggaugugaac      840

cccgagggca aauacagcuu uggugccacc ugcgugaaga aguguccccg uaauuaugug      900

gugacagauc acggcucgug cguccgagcc uguggggccg acagcuauga gauggaggaa      960

gacggcgucc gcaaguguaa gaagugcgaa gggccuugcc gcaaagugug uaacggaaua     1020

gguauuggug aauuuaaaga cucacucucc auaaaugcua cgaauauuaa acacuucaaa     1080

aacugcaccu ccaucagugg cgaucuccac auccugccgg uggcauuuag gggugacucc     1140

uucacacaua cuccuccucu ggauccacag gaacuggaua uucugaaaac cguaaaggaa     1200

aucacagguu ugagcuga                                                   1218


<210>  1366
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__CCDS47587.1

<400>  1366
augcgcccca gcggcaccgc cggggccgcg cugcucgccc ugcuggccgc ccucugcccg       60

gccucccggg cgcuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cucgggaccu ucgaggacca cuuccugucc cugcagcgca uguucaacaa cugcgagguc      180

gugcucggca accuggagau caccuacgug cagcggaacu acgaccugag cuuccucaag      240

accauccagg aggucgccgg guacgugcug aucgcccuga acacggugga gcgcaucccc      300

cucgagaacc ugcagaucau ccggggcaac auguacuacg agaacuccua cgcccuggcg      360

guccucagca acuacgacgc caacaagacc ggccugaagg agcugcccau gcgcaaccuc      420

caggagaucc ugcacggggc cgugcgguuc uccaacaacc ccgcccugug caacguggag      480

agcauccagu ggcgcgacau cgucuccagc gacuuccucu ccaacaugag cauggacuuc      540

cagaaccacc ugggcuccug ccagaagugc gacccgagcu gccccaacgg guccugcugg      600

ggcgccgggg aggagaacug ccagaagcug accaagauca ucugcgcgca gcagugcagc      660

ggccggugcc gcggcaaguc ccccagcgac ugcugccaca accagugcgc cgccgggugc      720

accggccccc gggaguccga cugccucgug ugccgcaagu uccgggacga ggccacgugc      780

aaggacacgu gcccgccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggga aguacagcuu cggcgcgacc ugcgucaaga agugcccgcg caacuacgug      900

gugaccgacc acggcagcug cguccgggcc ugcggggccg acuccuacga gauggaggag      960

gacggcgugc gcaagugcaa gaagugcgag gggcccugcc ggaaggugug caacggcauc     1020

gggaucggcg aguucaagga cagccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucuccgg cgaccugcac auccugcccg ucgccuuccg cggggacagc     1140

uucacgcaca cgcccccgcu cgacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcc ucuccuga                                                   1218


<210>  1367
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__CCDS47587.1

<400>  1367
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagguc ugccagggca ccuccaacaa gcucacccag      120

cucggcaccu ucgaggacca cuuccucucc cuccagcgca uguucaacaa cugcgagguc      180

guccucggca accucgagau caccuacguc cagcgcaacu acgaccucuc cuuccucaag      240

accauccagg aggucgccgg cuacguccuc aucgcccuca acaccgucga gcgcaucccc      300

cucgagaacc uccagaucau ccgcggcaac auguacuacg agaacuccua cgcccucgcc      360

guccucucca acuacgacgc caacaagacc ggccucaagg agcuccccau gcgcaaccuc      420

caggagaucc uccacggcgc cguccgcuuc uccaacaacc ccgcccucug caacgucgag      480

uccauccagu ggcgcgacau cgucuccucc gacuuccucu ccaacauguc cauggacuuc      540

cagaaccacc ucggcuccug ccagaagugc gaccccuccu gccccaacgg cuccugcugg      600

ggcgccggcg aggagaacug ccagaagcuc accaagauca ucugcgccca gcagugcucc      660

ggccgcugcc gcggcaaguc ccccuccgac ugcugccaca accagugcgc cgccggcugc      720

accggccccc gcgaguccga cugccucguc ugccgcaagu uccgcgacga ggccaccugc      780

aaggacaccu gccccccccu caugcucuac aaccccacca ccuaccagau ggacgucaac      840

cccgagggca aguacuccuu cggcgccacc ugcgucaaga agugcccccg caacuacguc      900

gucaccgacc acggcuccug cguccgcgcc ugcggcgccg acuccuacga gauggaggag      960

gacggcgucc gcaagugcaa gaagugcgag ggccccugcc gcaaggucug caacggcauc     1020

ggcaucggcg aguucaagga cucccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcaccu ccaucuccgg cgaccuccac auccuccccg ucgccuuccg cggcgacucc     1140

uucacccaca cccccccccu cgacccccag gagcucgaca uccucaagac cgucaaggag     1200

aucaccggcc ucuccuga                                                   1218


<210>  1368
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__CCDS47587.1

<400>  1368
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagug ugucagggaa caucuaacaa gcugacucaa      120

cuagguacgu ucgaggacca cuuucucuca cugcagcgga uguucaauaa cugcgaaguc      180

guucuuggca aucuggagau caccuacgug cagcgcaacu augauuugag uuuucucaaa      240

acaauucagg aaguagccgg guacgugcug auagcucuga auacugucga gcgaauccca      300

cucgagaacu uacaaauuau ccguggaaau auguauuacg aaaacagcua ugcacuggcc      360

gugcuuucca auuacgacgc uaacaagacc ggcuugaaag agcugccgau gagaaaucua      420

caggaaauuc uccauggugc cguuagguuc ucuaacaauc ccgcgcugug uaacguggag      480

ucgauccagu ggcgggauau agucucaagc gacuuucuua guaauauguc cauggauuuc      540

cagaaccacc uggggucuug ccaaaagugu gacccuagcu gcccaaacgg auccuguugg      600

ggcgcaggcg aggaaaauug ccagaaguug acaaaaauca uuugugccca gcagugcuca      660

gggcgcugua gaggaaagag ucccagcgau ugcugccaua accaaugugc ugccgguugc      720

accggcccua gggagucuga cugucucgug ugccggaaau uucgcgauga agcaacuugu      780

aaggacacau gcccaccccu gauguuauau aauccuacca cguaccagau ggauguaaac      840

ccagagggga aauacuccuu cggagcuacu uguguuaaga agugcccgcg aaauuaugug      900

gucaccgacc acggcucaug ugugagagcc ugcggugcgg auagcuacga aauggaggag      960

gacgggguga ggaaauguaa gaaaugcgaa ggacccugcc ggaaggucug uaacggcauc     1020

ggcauugggg aguuuaaaga cagucugucu aucaaugcca caaacauaaa gcauuucaaa     1080

aauugcacuu ccauuagcgg agaucuccac auccuuccug uugcauuucg uggugacucg     1140

uucacccaca caccaccccu ggauccucag gaauuggaca uucuaaagac cgugaaggag     1200

aucacgggcc ugucuuga                                                   1218


<210>  1369
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__CCDS47587.1

<400>  1369
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cugggcaccu ucgaggacca cuuccugagc cugcagagaa uguucaacaa cugcgaggug      180

gugcugggca accuggagau caccuacgug cagagaaacu acgaccugag cuuccugaag      240

accauccagg agguggccgg cuacgugcug aucgcccuga acaccgugga gagaaucccc      300

cuggagaacc ugcagaucau cagaggcaac auguacuacg agaacagcua cgcccuggcc      360

gugcugagca acuacgacgc caacaagacc ggccugaagg agcugcccau gagaaaccug      420

caggagaucc ugcacggcgc cgugagauuc agcaacaacc ccgcccugug caacguggag      480

agcauccagu ggagagacau cgugagcagc gacuuccuga gcaacaugag cauggacuuc      540

cagaaccacc ugggcagcug ccagaagugc gaccccagcu gccccaacgg cagcugcugg      600

ggcgccggcg aggagaacug ccagaagcug accaagauca ucugcgccca gcagugcagc      660

ggcagaugca gaggcaagag ccccagcgac ugcugccaca accagugcgc cgccggcugc      720

accggcccca gagagagcga cugccuggug ugcagaaagu ucagagacga ggccaccugc      780

aaggacaccu gccccccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggca aguacagcuu cggcgccacc ugcgugaaga agugccccag aaacuacgug      900

gugaccgacc acggcagcug cgugagagcc ugcggcgccg acagcuacga gauggaggag      960

gacggcguga gaaagugcaa gaagugcgag ggccccugca gaaaggugug caacggcauc     1020

ggcaucggcg aguucaagga cagccugagc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucagcgg cgaccugcac auccugcccg uggccuucag aggcgacagc     1140

uucacccaca cccccccccu ggacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcc ugagcuga                                                   1218


<210>  1370
<211>  1218
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__CCDS47587.1

<400>  1370
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagug ugucagggaa caucuaacaa gcugacgcaa      120

cuuggcaccu ucgaggacca cuuucugagc cuccagcgca uguucaauaa cugcgaaguc      180

guucugggga aucuggagau cacauacgug cagagaaacu augaucucuc cuuucugaaa      240

accauucagg aaguggccgg auacguccuu aucgcucuga auacagugga gcggauuccg      300

cucgagaacc ugcaaaucau ucgcggcaau auguauuacg aaaacucuua ugcccuugcg      360

guucugagca auuacgacgc caacaagacc gggcucaaag agcugcccau gagaaaucug      420

caggaaaucc uccauggagc ugugcgguuc uccaacaauc cugcccugug uaacgucgag      480

ucuauccagu ggcgcgauau ugugagcucc gacuuucuua gcaauauguc uauggauuuc      540

cagaaccacc ugggcuccug ccaaaagugu gaccccagcu gcccuaacgg cucuuguugg      600

ggagcugggg aggaaaauug ccagaagcuc acaaaaauca uuugugccca gcagugcucc      660

ggcagauguc ggggaaagag ccccucugau ugcugccaua accaaugugc ggccgggugc      720

accggcccuc gcgaguccga cugucugguu ugcagaaaau uucgggauga agcuacgugu      780

aaggauaccu gcccgccccu uaugcuguau aauccuacaa ccuaccagau ggacgugaac      840

cccgagggga aauacagcuu cggagccaca ugugucaaga agugcccucg caauuaugug      900

gugaccgacc acggcuccug ugucagagcu ugcggcgccg auucuuacga aauggaggag      960

gacgggguuc ggaaauguaa gaaaugcgaa ggacccugcc gcaaggugug uaacggcauc     1020

gggauuggag aguuuaaaga cagccucucc aucaaugcca cgaacauuaa gcauuucaaa     1080

aauugcacaa gcaucucugg cgaucugcac auccugccgg uggcuuuuag aggggacucc     1140

uucacccaca caccuccccu cgauccucag gaacuggaca uucuuaagac cgucaaggag     1200

aucaccggac ugagcuga                                                   1218


<210>  1371
<211>  1210
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__P00533

<400>  1371

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp 
        995                 1000                1005            


Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe 
    1010                1015                1020                


Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala 
1025                1030                1035                1040


Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln 
                1045                1050                1055    


Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp 
            1060                1065                1070        


Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro 
        1075                1080                1085            


Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser 
    1090                1095                1100                


Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser 
1105                1110                1115                1120


Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro 
                1125                1130                1135    


Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp 
            1140                1145                1150        


Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp 
        1155                1160                1165            


Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn 
    1170                1175                1180                


Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val 
1185                1190                1195                1200


Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
                1205                1210


<210>  1372
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__AAG35789

<400>  1372
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaguu ugccaaggca cgaguaacaa gcucacgcag      120

uugggcacuu uugaagauca uuuucucagc cuccagagga uguucaauaa cugugaggug      180

guccuuggga auuuggaaau uaccuaugug cagaggaauu augaucuuuc cuucuuaaag      240

accauccagg agguggcugg uuauguccuc auugcccuca acacagugga gcgaauuccu      300

uuggaaaacc ugcagaucau cagaggaaau auguacuacg aaaauuccua ugccuuagca      360

gucuuaucua acuaugaugc aaauaaaacc ggacugaagg agcugcccau gagaaauuua      420

caggaaaucc ugcauggcgc cgugcgguuc agcaacaacc cugcccugug caacguggag      480

agcauccagu ggcgggacau agucagcagu gacuuucuca gcaacauguc gauggacuuc      540

cagaaccacc ugggcagcug ccaaaagugu gauccaagcu gucccaaugg gagcugcugg      600

ggugcaggag aggagaacug ccagaaacug accaaaauca ucugugccca gcagugcucc      660

gggcgcugcc guggcaaguc ccccagugac ugcugccaca accagugugc ugcaggcugc      720

acaggccccc gggagagcga cugccugguc ugccgcaaau uccgagacga agccacgugc      780

aaggacaccu gccccccacu caugcucuac aaccccacca cguaccagau ggaugugaac      840

cccgagggca aauacagcuu uggugccacc ugcgugaaga aguguccccg uaauuaugug      900

gugacagauc acggcucgug cguccgagcc uguggggccg acagcuauga gauggaggaa      960

gacggcgucc gcaaguguaa gaagugcgaa gggccuugcc gcaaagugug uaacggaaua     1020

gguauuggug aauuuaaaga cucacucucc auaaaugcua cgaauauuaa acacuucaaa     1080

aacugcaccu ccaucagugg cgaucuccac auccugccgg uggcauuuag gggugacucc     1140

uucacacaua cuccuccucu ggauccacag gaacuggaua uucugaaaac cguaaaggaa     1200

aucacagggu uuuugcugau ucaggcuugg ccugaaaaca ggacggaccu ccaugccuuu     1260

gagaaccuag aaaucauacg cggcaggacc aagcaacaug gucaguuuuc ucuugcaguc     1320

gucagccuga acauaacauc cuugggauua cgcucccuca aggagauaag ugauggagau     1380

gugauaauuu caggaaacaa aaauuugugc uaugcaaaua caauaaacug gaaaaaacug     1440

uuugggaccu ccggucagaa aaccaaaauu auaagcaaca gaggugaaaa cagcugcaag     1500

gccacaggcc aggucugcca ugccuugugc ucccccgagg gcugcugggg cccggagccc     1560

agggacugcg ucucuugccg gaaugucagc cgaggcaggg aaugcgugga caagugcaac     1620

cuucuggagg gugagccaag ggaguuugug gagaacucug agugcauaca gugccaccca     1680

gagugccugc cucaggccau gaacaucacc ugcacaggac ggggaccaga caacuguauc     1740

cagugugccc acuacauuga cggcccccac ugcgucaaga ccugcccggc aggagucaug     1800

ggagaaaaca acacccuggu cuggaaguac gcagacgccg gccaugugug ccaccugugc     1860

cauccaaacu gcaccuacgg augcacuggg ccaggucuug aaggcugucc aacgaauggg     1920

ccuaagaucc cguccaucgc cacugggaug gugggggccc uccucuugcu gcugguggug     1980

gcccugggga ucggccucuu caugcgaagg cgccacaucg uucggaagcg cacgcugcgg     2040

aggcugcugc aggagaggga gcuuguggag ccucuuacac ccaguggaga agcucccaac     2100

caagcucucu ugaggaucuu gaaggaaacu gaauucaaaa agaucaaagu gcugggcucc     2160

ggugcguucg gcacggugua uaagggacuc uggaucccag aaggugagaa aguuaaaauu     2220

cccgucgcua ucaaggaauu aagagaagca acaucuccga aagccaacaa ggaaauccuc     2280

gaugaagccu acgugauggc cagcguggac aacccccacg ugugccgccu gcugggcauc     2340

ugccucaccu ccaccgugca gcucaucacg cagcucaugc ccuucggcug ccuccuggac     2400

uauguccggg aacacaaaga caauauuggc ucccaguacc ugcucaacug gugugugcag     2460

aucgcaaagg gcaugaacua cuuggaggac cgucgcuugg ugcaccgcga ccuggcagcc     2520

aggaacguac uggugaaaac accgcagcau gucaagauca cagauuuugg gcuggccaaa     2580

cugcugggug cggaagagaa agaauaccau gcagaaggag gcaaagugcc uaucaagugg     2640

auggcauugg aaucaauuuu acacagaauc uauacccacc agagugaugu cuggagcuac     2700

ggggugaccg uuugggaguu gaugaccuuu ggauccaagc cauaugacgg aaucccugcc     2760

agcgagaucu ccuccauccu ggagaaagga gaacgccucc cucagccacc cauauguacc     2820

aucgaugucu acaugaucau ggucaagugc uggaugauag acgcagauag ucgcccaaag     2880

uuccgugagu ugaucaucga auucuccaaa auggcccgag acccccagcg cuaccuuguc     2940

auucaggggg augaaagaau gcauuugcca aguccuacag acuccaacuu cuaccgugcc     3000

cugauggaug aagaagacau ggacgacgug guggaugccg acgaguaccu caucccacag     3060

cagggcuucu ucagcagccc cuccacguca cggacucccc uccugagcuc ucugagugca     3120

accagcaaca auuccaccgu ggcuugcauu gauagaaaug ggcugcaaag cugucccauc     3180

aaggaagaca gcuucuugca gcgauacagc ucagacccca caggcgccuu gacugaggac     3240

agcauagacg acaccuuccu cccagugccu gaauacauaa accaguccgu ucccaaaagg     3300

cccgcuggcu cugugcagaa uccugucuau cacaaucagc cucugaaccc cgcgcccagc     3360

agagacccac acuaccagga cccccacagc acugcagugg gcaaccccga guaucucaac     3420

acuguccagc ccaccugugu caacagcaca uucgacagcc cugcccacug ggcccagaaa     3480

ggcagccacc aaauuagccu ggacaacccu gacuaccagc aggacuucuu ucccaaggaa     3540

gccaagccaa auggcaucuu uaagggcucc acagcugaaa augcagaaua ccuaaggguc     3600

gcgccacaaa gcagugaauu uauuggagca uga                                  3633


<210>  1373
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__AAG35789

<400>  1373
augcgcccca gcggcaccgc cggggccgcc cugcucgccc ugcuggccgc ccucugcccg       60

gccucccggg cgcuggagga gaagaaggug ugccagggca ccagcaacaa gcugacgcag      120

cucgggaccu ucgaggacca cuuccugucc cugcagcgca uguucaacaa cugcgagguc      180

gugcucggca accuggagau caccuacgug cagcggaacu acgaccugag cuuccucaag      240

accauccagg aggucgccgg guacgugcug aucgcccuga acacggugga gcgcaucccc      300

cucgagaacc ugcagaucau ccggggcaac auguacuacg agaacuccua cgcccuggcg      360

guccucagca acuacgacgc caacaagacc ggccugaagg agcugcccau gcgcaaccuc      420

caggagaucc ugcacggggc cgugcgguuc uccaacaacc ccgcccugug caacguggag      480

agcauccagu ggcgcgacau cgucuccagc gacuuccucu ccaacaugag cauggacuuc      540

cagaaccacc ugggcuccug ccagaagugc gacccgagcu gccccaacgg guccugcugg      600

ggcgccgggg aggagaacug ccagaagcug accaagauca ucugcgcgca gcagugcagc      660

ggccggugcc gcggcaaguc ccccagcgac ugcugccaca accagugcgc cgccgggugc      720

accggccccc gggaguccga cugccucgug ugccgcaagu uccgggacga ggccacgugc      780

aaggacacgu gcccgccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggga aguacagcuu cggcgcgacc ugcgucaaga agugcccgcg caacuacgug      900

gugaccgacc acggcagcug cguccgggcc ugcggggccg acuccuacga gauggaggag      960

gacggcgugc gcaagugcaa gaagugcgag gggcccugcc ggaaggugug caacggcauc     1020

gggaucggcg aguucaagga cagccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucuccgg cgaccugcac auccugcccg ucgccuuccg cggggacagc     1140

uucacgcaca cgcccccgcu cgacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccuccugau ccaggccugg cccgagaacc ggaccgaccu gcacgcguuc     1260

gagaaccucg agaucauccg cgggcggacc aagcagcacg gccaguucuc ccuggccgug     1320

gucagccuga acaucaccuc ccucgggcug cgcagccuga aggagaucuc cgacggcgac     1380

gugaucauca gcggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcug     1440

uucgggacgu ccggccagaa gaccaagauc aucagcaacc gcggggagaa cuccugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg ggugcugggg cccggagccc     1560

cgggacugcg ucuccugccg caacgugagc cggggccgcg agugcgucga caagugcaac     1620

cuccuggagg gggagccccg ggaguucgug gagaacuccg agugcaucca gugccacccc     1680

gagugccugc cgcaggcgau gaacaucacg ugcaccggcc gcgggcccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgucaug     1800

ggggagaaca acacccuggu guggaaguac gccgacgcgg gccacgugug ccaccucugc     1860

cacccgaacu gcaccuacgg gugcacgggc cccgggcugg agggcugccc caccaacggc     1920

ccgaagaucc ccagcaucgc caccgggaug gucggcgccc ugcuccugcu gcucguggug     1980

gcccugggga ucggccuguu caugcggcgc cggcacaucg uccgcaagcg gacccuccgc     2040

cggcugcugc aggagcgcga gcucguggag ccccugacgc ccagcgggga ggccccgaac     2100

caggcgcugc uccggauccu gaaggagacc gaguucaaga agaucaaggu gcugggcucc     2160

ggcgccuucg ggaccgucua caagggccuc uggauccccg agggggagaa ggugaagauc     2220

cccguggcca ucaaggagcu gcgcgaggcc accagcccca aggccaacaa ggagauccug     2280

gacgaggcgu acgucauggc cuccguggac aacccgcacg ugugccggcu ccugggcauc     2340

ugccugacca gcacggucca gcucaucacc cagcugaugc ccuucgggug ccugcucgac     2400

uacgugcgcg agcacaagga caacaucggc ucccaguacc ugcugaacug gugcgugcag     2460

aucgccaagg gcaugaacua ccucgaggac cggcgccugg uccaccgcga ccuggccgcc     2520

cggaacgugc ucgugaagac gccccagcac gucaagauca ccgacuucgg gcuggcgaag     2580

cugcucggcg ccgaggagaa ggaguaccac gccgagggcg ggaaggugcc caucaagugg     2640

auggcccugg agagcauccu gcaccgcauc uacacccacc aguccgacgu guggagcuac     2700

ggggucaccg ugugggagcu caugaccuuc ggcuccaagc cguacgacgg cauccccgcg     2760

agcgagaucu ccagcauccu ggagaagggg gagcggcugc cccagccccc gaucugcacc     2820

aucgacgugu acaugaucau ggucaagugc uggaugaucg acgccgacuc ccgccccaag     2880

uuccgggagc ucaucaucga guucagcaag auggcccgcg acccccagcg guaccuggug     2940

auccagggcg acgagcgcau gcaccucccc uccccgacgg acagcaacuu cuaccgggcc     3000

cugauggacg aggaggacau ggacgacgug gucgacgccg acgaguaccu gaucccccag     3060

cagggguucu ucuccagccc cagcaccucc cgcacgcccc ugcucagcuc ccugagcgcg     3120

accuccaaca acagcaccgu ggccugcauc gaccggaacg gccugcaguc cugcccgauc     3180

aaggaggaca gcuuccucca gcgcuacucc agcgacccca ccggcgcccu gaccgaggac     3240

uccaucgacg acaccuuccu gcccgugccg gaguacauca accagagcgu ccccaagcgg     3300

cccgccgggu ccgugcagaa ccccguguac cacaaccagc cgcucaaccc cgcccccagc     3360

cgcgaccccc acuaccagga cccgcacucc acggcggucg gcaaccccga guaccugaac     3420

accgugcagc cgaccugcgu gaacagcacc uucgacuccc ccgcccacug ggcccagaag     3480

gggagccacc agaucucccu ggacaacccc gacuaccagc aggacuucuu ccccaaggag     3540

gccaagccca acggcaucuu caaggggagc acggccgaga acgcggagua ccuccggguc     3600

gcgccccaga gcuccgaguu caucggcgcc uga                                  3633


<210>  1374
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__AAG35789

<400>  1374
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagguc ugccagggca ccuccaacaa gcucacccag      120

cucggcaccu ucgaggacca cuuccucucc cuccagcgca uguucaacaa cugcgagguc      180

guccucggca accucgagau caccuacguc cagcgcaacu acgaccucuc cuuccucaag      240

accauccagg aggucgccgg cuacguccuc aucgcccuca acaccgucga gcgcaucccc      300

cucgagaacc uccagaucau ccgcggcaac auguacuacg agaacuccua cgcccucgcc      360

guccucucca acuacgacgc caacaagacc ggccucaagg agcuccccau gcgcaaccuc      420

caggagaucc uccacggcgc cguccgcuuc uccaacaacc ccgcccucug caacgucgag      480

uccauccagu ggcgcgacau cgucuccucc gacuuccucu ccaacauguc cauggacuuc      540

cagaaccacc ucggcuccug ccagaagugc gaccccuccu gccccaacgg cuccugcugg      600

ggcgccggcg aggagaacug ccagaagcuc accaagauca ucugcgccca gcagugcucc      660

ggccgcugcc gcggcaaguc ccccuccgac ugcugccaca accagugcgc cgccggcugc      720

accggccccc gcgaguccga cugccucguc ugccgcaagu uccgcgacga ggccaccugc      780

aaggacaccu gccccccccu caugcucuac aaccccacca ccuaccagau ggacgucaac      840

cccgagggca aguacuccuu cggcgccacc ugcgucaaga agugcccccg caacuacguc      900

gucaccgacc acggcuccug cguccgcgcc ugcggcgccg acuccuacga gauggaggag      960

gacggcgucc gcaagugcaa gaagugcgag ggccccugcc gcaaggucug caacggcauc     1020

ggcaucggcg aguucaagga cucccucucc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcaccu ccaucuccgg cgaccuccac auccuccccg ucgccuuccg cggcgacucc     1140

uucacccaca cccccccccu cgacccccag gagcucgaca uccucaagac cgucaaggag     1200

aucaccggcu uccuccucau ccaggccugg cccgagaacc gcaccgaccu ccacgccuuc     1260

gagaaccucg agaucauccg cggccgcacc aagcagcacg gccaguucuc ccucgccguc     1320

gucucccuca acaucaccuc ccucggccuc cgcucccuca aggagaucuc cgacggcgac     1380

gucaucaucu ccggcaacaa gaaccucugc uacgccaaca ccaucaacug gaagaagcuc     1440

uucggcaccu ccggccagaa gaccaagauc aucuccaacc gcggcgagaa cuccugcaag     1500

gccaccggcc aggucugcca cgcccucugc ucccccgagg gcugcugggg ccccgagccc     1560

cgcgacugcg ucuccugccg caacgucucc cgcggccgcg agugcgucga caagugcaac     1620

cuccucgagg gcgagccccg cgaguucguc gagaacuccg agugcaucca gugccacccc     1680

gagugccucc cccaggccau gaacaucacc ugcaccggcc gcggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgucaaga ccugccccgc cggcgucaug     1800

ggcgagaaca acacccucgu cuggaaguac gccgacgccg gccacgucug ccaccucugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccucg agggcugccc caccaacggc     1920

cccaagaucc ccuccaucgc caccggcaug gucggcgccc uccuccuccu ccucgucguc     1980

gcccucggca ucggccucuu caugcgccgc cgccacaucg uccgcaagcg cacccuccgc     2040

cgccuccucc aggagcgcga gcucgucgag ccccucaccc ccuccggcga ggcccccaac     2100

caggcccucc uccgcauccu caaggagacc gaguucaaga agaucaaggu ccucggcucc     2160

ggcgccuucg gcaccgucua caagggccuc uggauccccg agggcgagaa ggucaagauc     2220

cccgucgcca ucaaggagcu ccgcgaggcc accuccccca aggccaacaa ggagauccuc     2280

gacgaggccu acgucauggc cuccgucgac aacccccacg ucugccgccu ccucggcauc     2340

ugccucaccu ccaccgucca gcucaucacc cagcucaugc ccuucggcug ccuccucgac     2400

uacguccgcg agcacaagga caacaucggc ucccaguacc uccucaacug gugcguccag     2460

aucgccaagg gcaugaacua ccucgaggac cgccgccucg uccaccgcga ccucgccgcc     2520

cgcaacgucc ucgucaagac cccccagcac gucaagauca ccgacuucgg ccucgccaag     2580

cuccucggcg ccgaggagaa ggaguaccac gccgagggcg gcaagguccc caucaagugg     2640

auggcccucg aguccauccu ccaccgcauc uacacccacc aguccgacgu cugguccuac     2700

ggcgucaccg ucugggagcu caugaccuuc ggcuccaagc ccuacgacgg cauccccgcc     2760

uccgagaucu ccuccauccu cgagaagggc gagcgccucc cccagccccc caucugcacc     2820

aucgacgucu acaugaucau ggucaagugc uggaugaucg acgccgacuc ccgccccaag     2880

uuccgcgagc ucaucaucga guucuccaag auggcccgcg acccccagcg cuaccucguc     2940

auccagggcg acgagcgcau gcaccucccc ucccccaccg acuccaacuu cuaccgcgcc     3000

cucauggacg aggaggacau ggacgacguc gucgacgccg acgaguaccu caucccccag     3060

cagggcuucu ucuccucccc cuccaccucc cgcacccccc uccucuccuc ccucuccgcc     3120

accuccaaca acuccaccgu cgccugcauc gaccgcaacg gccuccaguc cugccccauc     3180

aaggaggacu ccuuccucca gcgcuacucc uccgacccca ccggcgcccu caccgaggac     3240

uccaucgacg acaccuuccu ccccgucccc gaguacauca accaguccgu ccccaagcgc     3300

cccgccggcu ccguccagaa ccccgucuac cacaaccagc cccucaaccc cgcccccucc     3360

cgcgaccccc acuaccagga cccccacucc accgccgucg gcaaccccga guaccucaac     3420

accguccagc ccaccugcgu caacuccacc uucgacuccc ccgcccacug ggcccagaag     3480

ggcucccacc agaucucccu cgacaacccc gacuaccagc aggacuucuu ccccaaggag     3540

gccaagccca acggcaucuu caagggcucc accgccgaga acgccgagua ccuccgcguc     3600

gccccccagu ccuccgaguu caucggcgcc uga                                  3633


<210>  1375
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__AAG35789

<400>  1375
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagug ugucagggaa caucuaacaa gcugacucaa      120

cuagguacgu ucgaggacca cuuucucuca cugcagcgga uguucaauaa cugcgaaguc      180

guucuuggca aucuggagau caccuacgug cagcgcaacu augauuugag uuuucucaaa      240

acaauucagg aaguagccgg guacgugcug auagcucuga auacugucga gcgaauccca      300

cucgagaacu uacaaauuau ccguggaaau auguauuacg aaaacagcua ugcacuggcc      360

gugcuuucca auuacgacgc uaacaagacc ggcuugaaag agcugccgau gagaaaucua      420

caggaaauuc uccauggugc cguuagguuc ucuaacaauc ccgcgcugug uaacguggag      480

ucgauccagu ggcgggauau agucucaagc gacuuucuua guaauauguc cauggauuuc      540

cagaaccacc uggggucuug ccaaaagugu gacccuagcu gcccaaacgg auccuguugg      600

ggcgcaggcg aggaaaauug ccagaaguug acaaaaauca uuugugccca gcagugcuca      660

gggcgcugua gaggaaagag ucccagcgau ugcugccaua accaaugugc ugccgguugc      720

accggcccua gggagucuga cugucucgug ugccggaaau uucgcgauga agcaacuugu      780

aaggacacau gcccaccccu gauguuauau aauccuacca cguaccagau ggauguaaac      840

ccagagggga aauacuccuu cggagcuacu uguguuaaga agugcccgcg aaauuaugug      900

gucaccgacc acggcucaug ugugagagcc ugcggugcgg auagcuacga aauggaggag      960

gacgggguga ggaaauguaa gaaaugcgaa ggacccugcc ggaaggucug uaacggcauc     1020

ggcauugggg aguuuaaaga cagucugucu aucaaugcca caaacauaaa gcauuucaaa     1080

aauugcacuu ccauuagcgg agaucuccac auccuuccug uugcauuucg uggugacucg     1140

uucacccaca caccaccccu ggauccucag gaauuggaca uucuaaagac cgugaaggag     1200

aucacgggcu uucugcucau ccaggcuugg ccagaaaacc gcacugaucu gcaugccuuc     1260

gagaaucuug agauuauaag agggaggaca aaacaacacg gacaguucuc ucuggcugua     1320

guguccuuga acaucaccuc acucggccug cggaguuuaa aggaaauuag cgacggugau     1380

gucaucauau ccgggaauaa aaaccugugu uaugccaaua cuauuaacug gaagaaacua     1440

uuuggcacau cuggacagaa gaccaagauc aucagcaacc gaggcgaaaa uucaugcaaa     1500

gcaacggggc aaguguguca ugcccucugc agucccgaag gauguugggg uccggagccu     1560

cgcgacugcg uuuccuguag aaacgugagc aggggccggg aaugcgucga uaaguguaau     1620

cugcuugagg gggagccccg cgaguucgug gagaacucug aaugcauuca gugccaccca     1680

gaguguuugc cucaggcuau gaauauuacc ugcacaggaa gaggccccga caacuguauu     1740

cagugcgcgc acuacauaga ugguccacau uguguaaaaa cuugccccgc agggguuaug     1800

ggcgagaaua acacccuggu guggaaguau gccgacgcug gacacgucug ucaucucugc     1860

cacccuaauu guacauacgg cugcacuggg ccaggacugg aagguugucc gaccaacggc     1920

cccaaaaucc cuucaauugc cacagggaug gugggagcac uucuguugcu ccuggucgug     1980

gccuuaggca ucggucuguu uaugaggcgu cggcauaucg uucgaaagag aacccuaagg     2040

cgccuccugc aagagcggga acuuguggag ccauugacuc ccagugggga agcuccuaau     2100

caggcccugc ucagaauccu gaaggagacg gaguucaaaa agauaaaagu auuaggcagc     2160

ggagcauuug gcacagucua uaaggggcug uggaucccag aaggagagaa agugaagauu     2220

cccguugcga ucaaggaacu uagggaggcu accuccccga aagccaacaa ggaaauuuug     2280

gacgaggcau acgugauggc cucugucgau aauccucacg ugugccgccu ccugggcauc     2340

ugccuaacuu cgaccguaca gcugauaaca cagcucaugc cauucgguug ucugcuugac     2400

uacgugcgag agcacaaaga uaacaucggg agccaauauu ugcugaauug gugcguucag     2460

auugcuaagg gaaugaacua cuuagaagac cggcgucucg uccauagaga ucuggccgca     2520

aggaacgugc uugugaaaac uccccagcac gucaagauca ccgacuuugg ccuggcuaaa     2580

uugcucggug ccgaggaaaa ggaguaucau gcggaaggcg ggaagguucc uauuaaaugg     2640

auggcccugg aguccauccu acaccgcaua uacacacacc agucagaugu guggaguuau     2700

ggagugacgg uaugggagcu gaugaccuuc ggcucuaagc ccuacgacgg gauuccagcu     2760

agcgaaaucu ccucaauucu cgagaaagga gaacggcugc cucaaccccc aaucuguacu     2820

auagaugucu auaugaucau ggugaagugc uggaugauug acgcagauag cagaccgaaa     2880

uuuagggagc uuaucauuga guucucuaag auggcccgag acccucagcg cuacuugguu     2940

auccagggcg augaacggau gcaucugccc uccccaacag acaguaauuu uuacagagcu     3000

uuaauggacg aggaagauau ggacgaugug gucgacgccg augaguaucu cauaccccaa     3060

caggguuucu uuagcucucc uuccaccuca aggacaccac ugcuuaguag ccugucggca     3120

acuuccaaca auucuaccgu ggcguguauu gaccguaacg ggcuacagag cugccccauc     3180

aaggaagauu cauuccucca gcgcuacagu uccgacccua cgggagcccu gaccgaggau     3240

ucuaucgacg auacauucuu gccgguucca gaguauauua aucaaagcgu gcccaaacgg     3300

ccugcuggcu ccguacagaa cccagucuac cacaaucagc cccugaaccc ugccccguca     3360

agagaccccc auuaucagga uccacacagc acugcagugg guaauccuga auacuuaaac     3420

accgugcaac ccacaugugu caauaguacu uuugacucuc cagcucauug ggcccagaag     3480

ggcucccacc agaucagccu cgacaacccu gauuaucagc aagacuucuu ucccaaagag     3540

gcaaagccaa augggauuuu caaaggaucg accgccgaaa acgcugagua ccugaggguu     3600

gcgccgcagu caucugaauu uauaggcgcc uga                                  3633


<210>  1376
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__AAG35789

<400>  1376
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cugggcaccu ucgaggacca cuuccugagc cugcagagaa uguucaacaa cugcgaggug      180

gugcugggca accuggagau caccuacgug cagagaaacu acgaccugag cuuccugaag      240

accauccagg agguggccgg cuacgugcug aucgcccuga acaccgugga gagaaucccc      300

cuggagaacc ugcagaucau cagaggcaac auguacuacg agaacagcua cgcccuggcc      360

gugcugagca acuacgacgc caacaagacc ggccugaagg agcugcccau gagaaaccug      420

caggagaucc ugcacggcgc cgugagauuc agcaacaacc ccgcccugug caacguggag      480

agcauccagu ggagagacau cgugagcagc gacuuccuga gcaacaugag cauggacuuc      540

cagaaccacc ugggcagcug ccagaagugc gaccccagcu gccccaacgg cagcugcugg      600

ggcgccggcg aggagaacug ccagaagcug accaagauca ucugcgccca gcagugcagc      660

ggcagaugca gaggcaagag ccccagcgac ugcugccaca accagugcgc cgccggcugc      720

accggcccca gagagagcga cugccuggug ugcagaaagu ucagagacga ggccaccugc      780

aaggacaccu gccccccccu gaugcuguac aaccccacca ccuaccagau ggacgugaac      840

cccgagggca aguacagcuu cggcgccacc ugcgugaaga agugccccag aaacuacgug      900

gugaccgacc acggcagcug cgugagagcc ugcggcgccg acagcuacga gauggaggag      960

gacggcguga gaaagugcaa gaagugcgag ggccccugca gaaaggugug caacggcauc     1020

ggcaucggcg aguucaagga cagccugagc aucaacgcca ccaacaucaa gcacuucaag     1080

aacugcacca gcaucagcgg cgaccugcac auccugcccg uggccuucag aggcgacagc     1140

uucacccaca cccccccccu ggacccccag gagcuggaca uccugaagac cgugaaggag     1200

aucaccggcu uccugcugau ccaggccugg cccgagaaca gaaccgaccu gcacgccuuc     1260

gagaaccugg agaucaucag aggcagaacc aagcagcacg gccaguucag ccuggccgug     1320

gugagccuga acaucaccag ccugggccug agaagccuga aggagaucag cgacggcgac     1380

gugaucauca gcggcaacaa gaaccugugc uacgccaaca ccaucaacug gaagaagcug     1440

uucggcacca gcggccagaa gaccaagauc aucagcaaca gaggcgagaa cagcugcaag     1500

gccaccggcc aggugugcca cgcccugugc agccccgagg gcugcugggg ccccgagccc     1560

agagacugcg ugagcugcag aaacgugagc agaggcagag agugcgugga caagugcaac     1620

cugcuggagg gcgagcccag agaguucgug gagaacagcg agugcaucca gugccacccc     1680

gagugccugc cccaggccau gaacaucacc ugcaccggca gaggccccga caacugcauc     1740

cagugcgccc acuacaucga cggcccccac ugcgugaaga ccugccccgc cggcgugaug     1800

ggcgagaaca acacccuggu guggaaguac gccgacgccg gccacgugug ccaccugugc     1860

caccccaacu gcaccuacgg cugcaccggc cccggccugg agggcugccc caccaacggc     1920

cccaagaucc ccagcaucgc caccggcaug gugggcgccc ugcugcugcu gcugguggug     1980

gcccugggca ucggccuguu caugagaaga agacacaucg ugagaaagag aacccugaga     2040

agacugcugc aggagagaga gcugguggag ccccugaccc ccagcggcga ggcccccaac     2100

caggcccugc ugagaauccu gaaggagacc gaguucaaga agaucaaggu gcugggcagc     2160

ggcgccuucg gcaccgugua caagggccug uggauccccg agggcgagaa ggugaagauc     2220

cccguggcca ucaaggagcu gagagaggcc accagcccca aggccaacaa ggagauccug     2280

gacgaggccu acgugauggc cagcguggac aacccccacg ugugcagacu gcugggcauc     2340

ugccugacca gcaccgugca gcugaucacc cagcugaugc ccuucggcug ccugcuggac     2400

uacgugagag agcacaagga caacaucggc agccaguacc ugcugaacug gugcgugcag     2460

aucgccaagg gcaugaacua ccuggaggac agaagacugg ugcacagaga ccuggccgcc     2520

agaaacgugc uggugaagac cccccagcac gugaagauca ccgacuucgg ccuggccaag     2580

cugcugggcg ccgaggagaa ggaguaccac gccgagggcg gcaaggugcc caucaagugg     2640

auggcccugg agagcauccu gcacagaauc uacacccacc agagcgacgu guggagcuac     2700

ggcgugaccg ugugggagcu gaugaccuuc ggcagcaagc ccuacgacgg cauccccgcc     2760

agcgagauca gcagcauccu ggagaagggc gagagacugc cccagccccc caucugcacc     2820

aucgacgugu acaugaucau ggugaagugc uggaugaucg acgccgacag cagacccaag     2880

uucagagagc ugaucaucga guucagcaag auggccagag acccccagag auaccuggug     2940

auccagggcg acgagagaau gcaccugccc agccccaccg acagcaacuu cuacagagcc     3000

cugauggacg aggaggacau ggacgacgug guggacgccg acgaguaccu gaucccccag     3060

cagggcuucu ucagcagccc cagcaccagc agaacccccc ugcugagcag ccugagcgcc     3120

accagcaaca acagcaccgu ggccugcauc gacagaaacg gccugcagag cugccccauc     3180

aaggaggaca gcuuccugca gagauacagc agcgacccca ccggcgcccu gaccgaggac     3240

agcaucgacg acaccuuccu gcccgugccc gaguacauca accagagcgu gcccaagaga     3300

cccgccggca gcgugcagaa ccccguguac cacaaccagc cccugaaccc cgcccccagc     3360

agagaccccc acuaccagga cccccacagc accgccgugg gcaaccccga guaccugaac     3420

accgugcagc ccaccugcgu gaacagcacc uucgacagcc ccgcccacug ggcccagaag     3480

ggcagccacc agaucagccu ggacaacccc gacuaccagc aggacuucuu ccccaaggag     3540

gccaagccca acggcaucuu caagggcagc accgccgaga acgccgagua ccugagagug     3600

gccccccaga gcagcgaguu caucggcgcc uga                                  3633


<210>  1377
<211>  3633
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__AAG35789

<400>  1377
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagug ugucagggaa caucuaacaa gcugacgcaa      120

cuuggcaccu ucgaggacca cuuucugagc cuccagcgca uguucaauaa cugcgaaguc      180

guucugggga aucuggagau cacauacgug cagagaaacu augaucucuc cuuucugaaa      240

accauucagg aaguggccgg auacguccuu aucgcucuga auacagugga gcggauuccg      300

cucgagaacc ugcaaaucau ucgcggcaau auguauuacg aaaacucuua ugcccuugcg      360

guucugagca auuacgacgc caacaagacc gggcucaaag agcugcccau gagaaaucug      420

caggaaaucc uccauggagc ugugcgguuc uccaacaauc cugcccugug uaacgucgag      480

ucuauccagu ggcgcgauau ugugagcucc gacuuucuua gcaauauguc uauggauuuc      540

cagaaccacc ugggcuccug ccaaaagugu gaccccagcu gcccuaacgg cucuuguugg      600

ggagcugggg aggaaaauug ccagaagcuc acaaaaauca uuugugccca gcagugcucc      660

ggcagauguc ggggaaagag ccccucugau ugcugccaua accaaugugc ggccgggugc      720

accggcccuc gcgaguccga cugucugguu ugcagaaaau uucgggauga agcuacgugu      780

aaggauaccu gcccgccccu uaugcuguau aauccuacaa ccuaccagau ggacgugaac      840

cccgagggga aauacagcuu cggagccaca ugugucaaga agugcccucg caauuaugug      900

gugaccgacc acggcuccug ugucagagcu ugcggcgccg auucuuacga aauggaggag      960

gacgggguuc ggaaauguaa gaaaugcgaa ggacccugcc gcaaggugug uaacggcauc     1020

gggauuggag aguuuaaaga cagccucucc aucaaugcca cgaacauuaa gcauuucaaa     1080

aauugcacaa gcaucucugg cgaucugcac auccugccgg uggcuuuuag aggggacucc     1140

uucacccaca caccuccccu cgauccucag gaacuggaca uucuuaagac cgucaaggag     1200

aucaccggau uucugcucau ucaagcgugg cccgaaaacc ggacagaucu gcaugccuuc     1260

gagaaucuug agaucauuag aggccgcacg aaacagcacg gccaguucag ccuggcugug     1320

guuucucuca acaucaccag ccuggggcug cggucccuca aggaaaucuc ugacggagau     1380

gugauuauca gcggcaauaa aaaccugugu uaugccaaua caauuaacug gaagaaacuu     1440

uuugggaccu ccggacagaa gacaaagauc auuagcaaca gaggcgaaaa uucuugcaaa     1500

gccaccgggc aagucuguca ugcucugugc ucccccgaag gcuguugggg accugagccg     1560

cgcgacugcg ugagcugucg gaacguuucu agaggccgcg aaugcgugga uaaguguaau     1620

cuccuggagg gggagccccg ggaguucguc gagaacuccg aaugcaucca gugccacccu     1680

gagugucugc cccaggccau gaauaucacg ugcacaggaa gaggcccuga caacuguauu     1740

cagugcgcgc acuacaucga ugggccccau ugugugaaaa ccugcccggc uggagucaug     1800

ggcgagaaua acacccuugu guggaaguau gccgacgccg ggcacguuug ucaucucugc     1860

cacccuaauu guacauacgg cugcaccgga cccggccugg aagggugucc uacaaacgga     1920

cccaaaauuc cuagcaucgc uacgggcaug gugggggccc ugcuccugcu ucuggucgug     1980

gcucucggaa uuggccuguu uaugcgccgg agacauaucg uucgcaagcg gacccugaga     2040

cggcuucucc aagagcgcga acugguggag ccccugacac cguccgggga agccccuaau     2100

caggcgcucc ugcggauucu uaaggagacc gaguucaaaa agaucaaagu ccugggcucu     2160

ggagccuuug gcacagugua uaaggggcuc uggauccccg aaggagagaa agugaagauu     2220

cccguugcua ucaaggaacu gagagaggcc accagcccua aagcuaacaa ggaaauucug     2280

gacgaggccu acgucauggc guccguggau aauccgcacg ugugcagacu ucucggcauc     2340

ugccugacgu cuaccgucca gcugauuaca cagcucaugc ccuucgggug ucugcuugac     2400

uacgugcgcg agcacaaaga uaacaucgga agccaauauc ugcucaauug gugcguucag     2460

aucgccaagg gcaugaacua ccuggaagac cggagacugg ugcaucgcga ucuugcugcc     2520

agaaacgucc ucgugaaaac cccucagcac guuaagauua cagacuuugg gcuggcuaaa     2580

cugcucggcg ccgaggaaaa ggaguaucau gccgaaggag gcaaggugcc caucaaaugg     2640

auggcucugg aguccauucu ucaccggauc uacacccacc agagcgaugu cuggucuuau     2700

ggggugacgg uuugggagcu gaugacauuc ggauccaagc cuuacgacgg cauucccgcg     2760

agcgaaaucu cuuccauccu cgagaaaggg gaacgccugc cucaaccccc gauuuguacc     2820

aucgaugugu auaugauuau ggucaagugc uggaugaucg acgccgauag cagaccuaaa     2880

uuucgggagc ugauuaucga guucucuaag auggcucgcg acccccagag auaccuugug     2940

auccagggag augaacggau gcaucugccu agccccacag acuccaauuu uuaccgcgcc     3000

cucauggacg aggaagauau ggacgaugug gucgacgccg augaguaucu gauuccgcaa     3060

cagggcuucu uuagcucucc uuccaccagc agaacacccc uccuguccuc ucuuagcgcu     3120

accuccaaca auucuacggu ugccuguauc gaccggaacg gccugcagag cugcccuauu     3180

aaggaagauu ccuuccucca gcgcuacucu agcgacccca ccggggcgcu gacagaggau     3240

uccaucgacg auaccuuccu gcccgugccu gaguauauua aucaaagcgu gccgaaaaga     3300

cccgcuggau cuguccagaa cccuguguac cacaaucagc cccuuaaccc ugcccccucc     3360

cgggacccuc auuaucagga uccgcacagc acagccguug gcaaucccga auaccugaac     3420

accgugcaac cuacgugugu caauucuaca uuugacuccc ccgcucauug ggcccagaag     3480

gggagccacc agaucucucu cgacaacccu gauuaucagc aagacuucuu ucccaaagag     3540

gcgaagccga auggaauuuu caaaggcucc accgcugaaa acgccgagua ccugagagug     3600

gccccucaga gcuccgaauu uaucggggcu uga                                  3633


<210>  1378
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__Q147T7

<400>  1378

Met Ala Ala Glu Asp Val Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg 
1               5                   10                  15      


Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala 
            20                  25                  30          


Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe 
        35                  40                  45              


Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr 
    50                  55                  60                  


Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser 
65                  70                  75                  80  


Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr 
                85                  90                  95      


Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met 
            100                 105                 110         


Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg 
        115                 120                 125             


Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser 
    130                 135                 140                 


Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser 
145                 150                 155                 160 


Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr 
                165                 170                 175     


His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val 
            180                 185                 190         


Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg 
        195                 200                 205             


Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr 
    210                 215                 220                 


Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr 
225                 230                 235                 240 


Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile 
                245                 250                 255     


Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys 
            260                 265                 270         


Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg 
        275                 280                 285             


Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys 
    290                 295                 300                 


Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys 
305                 310                 315                 320 


Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu 
                325                 330                 335     


Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys 
            340                 345                 350         


His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg 
        355                 360                 365             


Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His 
    370                 375                 380                 


Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu 
385                 390                 395                 400 


Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro 
                405                 410                 415     


Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr 
            420                 425                 430         


Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu 
        435                 440                 445             


Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Pro Leu His Gly Arg 
    450                 455                 460                 






<210>  1379
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__AAI18666

<400>  1379
auggcagcug aagacguuau caucugugcc cagcagugcu ccgggcgcug ccguggcaag       60

ucccccagug acugcugcca caaccagugu gcugcaggcu gcacaggccc ccgggagagc      120

gacugccugg ucugccgcaa auuccgagac gaagccacgu gcaaggacac cugcccccca      180

cucaugcucu acaaccccac cacguaccag auggauguga accccgaggg caaauacagc      240

uuuggugcca ccugcgugaa gaaguguccc cguaauuaug uggugacaga ucacggcucg      300

ugcguccgag ccuguggggc cgacagcuau gagauggagg aagacggcgu ccgcaagugu      360

aagaagugcg aagggccuug ccgcaaagug uguaacggaa uagguauugg ugaauuuaaa      420

gacucacucu ccauaaaugc uacgaauauu aaacacuuca aaaacugcac cuccaucagu      480

ggcgaucucc acauccugcc gguggcauuu aggggugacu ccuucacaca uacuccuccu      540

cuggauccac aggaacugga uauucugaaa accguaaagg aaaucacagg guuuuugcug      600

auucaggcuu ggccugaaaa caggacggac cuccaugccu uugagaaccu agaaaucaua      660

cgcggcagga ccaagcaaca uggucaguuu ucucuugcag ucgucagccu gaacauaaca      720

uccuugggau uacgcucccu caaggagaua agugauggag augugauaau uucaggaaac      780

aaaaauuugu gcuaugcaaa uacaauaaac uggaaaaaac uguuugggac cuccggucag      840

aaaaccaaaa uuauaagcaa cagaggugaa aacagcugca aggccacagg ccaggucugc      900

caugccuugu gcucccccga gggcugcugg ggcccggagc ccagggacug cgucucuugc      960

cggaauguca gccgaggcag ggaaugcgug gacaagugca accuucugga gggugagcca     1020

agggaguuug uggagaacuc ugagugcaua cagugccacc cagagugccu gccucaggcc     1080

augaacauca ccugcacagg acggggacca gacaacugua uccagugugc ccacuacauu     1140

gacggccccc acugcgucaa gaccugcccg gcaggaguca ugggagaaaa caacacccug     1200

gucuggaagu acgcagacgc uggccaugug ugccaccugu gccauccaaa cugcaccuac     1260

ggaugcacag ggccaggucu ugaaggcugu ccaacgaaug ggccuaagau cccguccauc     1320

gccacuggga uggugggggc ccuccucuug cugcuggugg uggcccuggg gaucgggccu     1380

cuucauggaa gauag                                                      1395


<210>  1380
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__AAI18666

<400>  1380
auggccgccg aggacgugau caucugcgcg cagcagugca gcggccgcug ccgggggaag       60

ucccccagcg acugcugcca caaccagugc gccgccggcu gcaccgggcc gcgcgagucc      120

gacugccugg ucugccggaa guuccgcgac gaggcgaccu gcaaggacac gugcccgccc      180

cucaugcugu acaaccccac caccuaccag auggacguga accccgaggg caaguacagc      240

uucggggcga ccugcgugaa gaagugcccc cggaacuacg ucgugacgga ccacggcucc      300

ugcgugcgcg ccugcggcgc cgacagcuac gagauggagg aggacggggu ccggaagugc      360

aagaagugcg agggccccug ccgcaaggug ugcaacggga ucggcaucgg ggaguucaag      420

gacucccuga gcaucaacgc caccaacauc aagcacuuca agaacugcac cuccaucagc      480

ggcgaccucc acauccugcc cguggccuuc cggggcgacu ccuucaccca cacgccgccc      540

cuggaccccc aggagcucga cauccugaag accgucaagg agaucaccgg guuccugcuc      600

auccaggccu ggcccgagaa ccgcaccgac cugcacgccu ucgagaaccu ggagaucauc      660

cggggccgca cgaagcagca cgggcaguuc agccucgccg uggugucccu gaacaucacc      720

agccugggcc uccggucccu gaaggagauc agcgacggcg acgucaucau cuccgggaac      780

aagaaccugu gcuacgccaa caccaucaac uggaagaagc uguucggcac cagcgggcag      840

aagacgaaga ucaucuccaa ccgcggcgag aacagcugca aggccaccgg ccaggugugc      900

cacgcgcucu gcagcccgga ggggugcugg ggccccgagc cccgggacug cguguccugc      960

cgcaacguca gccgggggcg cgagugcgug gacaagugca accugcucga gggcgagccc     1020

cgggaguucg uggagaacuc cgagugcauc cagugccacc cggagugccu gccccaggcc     1080

augaacauca cgugcaccgg gcgcggcccc gacaacugca uccagugcgc ccacuacauc     1140

gacgggcccc acugcgucaa gaccugcccg gccggcguga ugggcgagaa caacacccug     1200

guguggaagu acgccgacgc ggggcacguc ugccaccucu gccaccccaa cugcaccuac     1260

ggcugcaccg ggcccggccu ggaggggugc cccacgaacg gcccgaagau ccccagcauc     1320

gccaccggca uggugggggc ccugcuccug cugcucgugg ucgcccuggg caucgggccc     1380

cugcacggcc gguga                                                      1395


<210>  1381
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__AAI18666

<400>  1381
auggccgccg aggacgucau caucugcgcc cagcagugcu ccggccgcug ccgcggcaag       60

ucccccuccg acugcugcca caaccagugc gccgccggcu gcaccggccc ccgcgagucc      120

gacugccucg ucugccgcaa guuccgcgac gaggccaccu gcaaggacac cugccccccc      180

cucaugcucu acaaccccac caccuaccag auggacguca accccgaggg caaguacucc      240

uucggcgcca ccugcgucaa gaagugcccc cgcaacuacg ucgucaccga ccacggcucc      300

ugcguccgcg ccugcggcgc cgacuccuac gagauggagg aggacggcgu ccgcaagugc      360

aagaagugcg agggccccug ccgcaagguc ugcaacggca ucggcaucgg cgaguucaag      420

gacucccucu ccaucaacgc caccaacauc aagcacuuca agaacugcac cuccaucucc      480

ggcgaccucc acauccuccc cgucgccuuc cgcggcgacu ccuucaccca cacccccccc      540

cucgaccccc aggagcucga cauccucaag accgucaagg agaucaccgg cuuccuccuc      600

auccaggccu ggcccgagaa ccgcaccgac cuccacgccu ucgagaaccu cgagaucauc      660

cgcggccgca ccaagcagca cggccaguuc ucccucgccg ucgucucccu caacaucacc      720

ucccucggcc uccgcucccu caaggagauc uccgacggcg acgucaucau cuccggcaac      780

aagaaccucu gcuacgccaa caccaucaac uggaagaagc ucuucggcac cuccggccag      840

aagaccaaga ucaucuccaa ccgcggcgag aacuccugca aggccaccgg ccaggucugc      900

cacgcccucu gcucccccga gggcugcugg ggccccgagc cccgcgacug cgucuccugc      960

cgcaacgucu cccgcggccg cgagugcguc gacaagugca accuccucga gggcgagccc     1020

cgcgaguucg ucgagaacuc cgagugcauc cagugccacc ccgagugccu cccccaggcc     1080

augaacauca ccugcaccgg ccgcggcccc gacaacugca uccagugcgc ccacuacauc     1140

gacggccccc acugcgucaa gaccugcccc gccggcguca ugggcgagaa caacacccuc     1200

gucuggaagu acgccgacgc cggccacguc ugccaccucu gccaccccaa cugcaccuac     1260

ggcugcaccg gccccggccu cgagggcugc cccaccaacg gccccaagau ccccuccauc     1320

gccaccggca uggucggcgc ccuccuccuc cuccucgucg ucgcccucgg caucggcccc     1380

cuccacggcc gcuga                                                      1395


<210>  1382
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__AAI18666

<400>  1382
auggccgcug aggacgugau cauuugcgca cagcaaugua gcggcagaug cagggggaag       60

ucccccucug auuguugcca caaccagugu gccgcgggau gcaccggucc ucgggaauca      120

gacugucugg ucugccgcaa auuccgagau gaggcuacau guaaggacac uugcccaccg      180

cucaugcuuu acaaucccac gaccuaucag auggauguua acccugaagg caaauacagu      240

uuuggggcca caugugugaa gaaaugccca cguaauuaug uagugacuga ccauggaagc      300

ugcgucagag cauguggcgc cgauuccuac gagauggaag aggacggugu gaggaagugc      360

aagaaaugug aggggcccug ccggaagguu uguaacggaa uaggcaucgg cgaguucaaa      420

gauucucugu cgauuaaugc uaccaacauc aagcacuuua aaaauugcac aucaauuagc      480

ggggacuugc auaucuuacc uguggcauuc cgcggagaua guuuuaccca cacuccaccc      540

cuggacccuc aggaacuaga uauacucaag acagucaagg aaaucaccgg uuuccugcuu      600

auucaagccu ggccagagaa cagaacggac cugcaugcuu uugagaauuu ggaaaucauu      660

aggggccgga cuaaacagca cgggcaguuc ucccucgccg ugguaucucu gaacaucacc      720

agccugggac uccgcuccuu aaaggagaua ucagacggcg auguuauuau cagugguaau      780

aaaaaccugu guuaugcgaa uacaauuaac uggaagaaac uuuuugggac uagcggacag      840

aagaccaaaa ucaucucuaa ucgaggcgaa aacuccugca aggcaacagg ccaagugugu      900

cacgccuugu gcucaccgga gggguguugg ggacccgaac cuagagacug cgucagcugc      960

aggaacguga gucggggucg ugagugugug gauaagugca aucugcuaga gggcgaacca     1020

cgcgaguucg ucgaaaacuc ugaguguauu cagugccauc ccgaaugucu cccucaggcu     1080

augaauauaa ccugcacggg gagaggacca gacaacugua uccagugcgc ccacuacauu     1140

gauggccccc auuguguuaa aacuugcccg gcugguguga ugggggagaa uaacacacug     1200

guauggaagu augcagacgc cggccacgug ugucaccuuu gccauccuaa uugcaccuac     1260

ggauguacug gccccgggcu ggagggaugc ccaacaaacg guccuaaaau ccccuccaua     1320

gcgaccggca uggucggggc cuugcuccug uuacuggugg uugcacucgg aauuggccca     1380

cuucacggua gguga                                                      1395


<210>  1383
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__AAI18666

<400>  1383
auggccgccg aggacgugau caucugcgcc cagcagugca gcggcagaug cagaggcaag       60

agccccagcg acugcugcca caaccagugc gccgccggcu gcaccggccc cagagagagc      120

gacugccugg ugugcagaaa guucagagac gaggccaccu gcaaggacac cugccccccc      180

cugaugcugu acaaccccac caccuaccag auggacguga accccgaggg caaguacagc      240

uucggcgcca ccugcgugaa gaagugcccc agaaacuacg uggugaccga ccacggcagc      300

ugcgugagag ccugcggcgc cgacagcuac gagauggagg aggacggcgu gagaaagugc      360

aagaagugcg agggccccug cagaaaggug ugcaacggca ucggcaucgg cgaguucaag      420

gacagccuga gcaucaacgc caccaacauc aagcacuuca agaacugcac cagcaucagc      480

ggcgaccugc acauccugcc cguggccuuc agaggcgaca gcuucaccca cacccccccc      540

cuggaccccc aggagcugga cauccugaag accgugaagg agaucaccgg cuuccugcug      600

auccaggccu ggcccgagaa cagaaccgac cugcacgccu ucgagaaccu ggagaucauc      660

agaggcagaa ccaagcagca cggccaguuc agccuggccg uggugagccu gaacaucacc      720

agccugggcc ugagaagccu gaaggagauc agcgacggcg acgugaucau cagcggcaac      780

aagaaccugu gcuacgccaa caccaucaac uggaagaagc uguucggcac cagcggccag      840

aagaccaaga ucaucagcaa cagaggcgag aacagcugca aggccaccgg ccaggugugc      900

cacgcccugu gcagccccga gggcugcugg ggccccgagc ccagagacug cgugagcugc      960

agaaacguga gcagaggcag agagugcgug gacaagugca accugcugga gggcgagccc     1020

agagaguucg uggagaacag cgagugcauc cagugccacc ccgagugccu gccccaggcc     1080

augaacauca ccugcaccgg cagaggcccc gacaacugca uccagugcgc ccacuacauc     1140

gacggccccc acugcgugaa gaccugcccc gccggcguga ugggcgagaa caacacccug     1200

guguggaagu acgccgacgc cggccacgug ugccaccugu gccaccccaa cugcaccuac     1260

ggcugcaccg gccccggccu ggagggcugc cccaccaacg gccccaagau ccccagcauc     1320

gccaccggca uggugggcgc ccugcugcug cugcuggugg uggcccuggg caucggcccc     1380

cugcacggca gauga                                                      1395


<210>  1384
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__AAI18666

<400>  1384
auggccgcug aggacgugau cauuugcgcc cagcaaugua gcggcagaug ccgggggaag       60

ucccccucug auuguugcca caaccagugu gcggcuggau gcaccggccc ucgcgaaagc      120

gacugucugg ucugcagaaa auuccgggau gaggccacau guaaggacac gugcccgccc      180

cucaugcugu acaauccuac cacauaucag auggauguua accccgaagg gaaauacucc      240

uuuggagcca ccugugugaa gaaaugcccu cgcaauuaug uggucacaga ccauggcucu      300

ugcgugagag cuuguggggc cgauagcuac gagauggaag aggacggagu ucggaagugc      360

aagaaaugug agggccccug ccgcaaggug uguaacggca ucgggauugg agaguucaaa      420

gauucccuuu cuaucaaugc uaccaacauu aagcacuuua aaaauugcac aagcaucucc      480

ggcgaccugc auauccuccc ugucgccuuc agaggggaua gcuuuaccca cacgccgccc      540

cuggacccuc aggaacuuga uauucugaag accgugaagg aaaucacagg auuccuccug      600

auucaagcgu ggcccgagaa ccggaccgac cugcaugccu uugagaaucu cgaaaucauu      660

cgcggcagaa caaaacagca cgggcaguuc ucucuggcug uugugucccu uaacaucacc      720

agccugggac uccggucucu gaaggagauu uccgacggcg augucaucau cagcggcaau      780

aaaaaccuuu guuaugccaa uacgauuaac uggaagaaac uguuugggac aucuggacag      840

aagaccaaaa ucauuuccaa ucgcggcgaa aacagcugca aggcuacagg gcaagugugu      900

cacgcccucu gcuccccuga gggauguugg ggccccgaac cgagagacug cgugucuugc      960

cggaacguca gccgcgggag agaguguguu gauaagugca aucugcugga gggagaaccu     1020

cgggaguucg uggaaaacuc cgaguguauc cagugccauc ccgaaugucu cccucaggcg     1080

augaauauua ccugcaccgg cagaggcccc gacaacugua uccagugcgc ccacuacauc     1140

gaugggcccc auugugugaa aacaugcccu gcuggaguca ugggcgagaa uaacacgcug     1200

guguggaagu augccgacgc ugggcacguu ugucaccuuu gccauccgaa uugcaccuac     1260

ggauguacag gccccgggcu ggagggcugc ccuaccaacg gacccaaaau uccuagcauc     1320

gccacaggca uggugggggc ccuccugcuu cugcucgucg uggcucuggg aauuggcccc     1380

cugcacgggc gcuga                                                      1395


<210>  1385
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__Q504U8

<400>  1385

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn 
        995                 1000                1005            


Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr 
    1010                1015                1020                


Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr 
1025                1030                1035                1040


Phe Leu Pro Val Pro Gly Glu Trp Leu Val Trp Lys Gln Ser Cys Ser 
                1045                1050                1055    


Ser Thr Ser Ser Thr His Ser Ala Ala Ala Ser Leu Gln Cys Pro Ser 
            1060                1065                1070        


Gln Val Leu Pro Pro Ala Ser Pro Glu Gly Glu Thr Val Ala Asp Leu 
        1075                1080                1085            


Gln Thr Gln 
    1090    


<210>  1386
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__AAH94761

<400>  1386
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaguu ugccaaggca cgaguaacaa gcucacgcag      120

uugggcacuu uugaagauca uuuucucagc cuccagagga uguucaauaa cugugaggug      180

guccuuggga auuuggaaau uaccuaugug cagaggaauu augaucuuuc cuucuuaaag      240

accauccagg agguggcugg uuauguccuc auugcccuca acacagugga gcgaauuccu      300

uuggaaaacc ugcagaucau cagaggaaau auguacuacg aaaauuccua ugccuuagca      360

gucuuaucua acuaugaugc aaauaaaacc ggacugaagg agcugcccau gagaaauuua      420

cagggacaaa agugugaucc aagcuguccc aaugggagcu gcuggggugc aggagaggag      480

aacugccaga aacugaccaa aaucaucugu gcccagcagu gcuccgggcg cugccguggc      540

aaguccccca gugacugcug ccacaaccag ugugcugcag gcugcacagg cccccgggag      600

agcgacugcc uggucugccg caaauuccga gacgaagcca cgugcaagga caccugcccc      660

ccacucaugc ucuacaaccc caccacguac cagauggaug ugaaccccga gggcaaauac      720

agcuuuggug ccaccugcgu gaagaagugu ccccguaauu auguggugac agaucacggc      780

ucgugcgucc gagccugugg ggccgacagc uaugagaugg aggaagacgg cguccgcaag      840

uguaagaagu gcgaagggcc uugccgcaaa guguguaacg gaauagguau uggugaauuu      900

aaagacucac ucuccauaaa ugcuacgaau auuaaacacu ucaaaaacug caccuccauc      960

aguggcgauc uccacauccu gccgguggca uuuaggggug acuccuucac acauacuccu     1020

ccucuggauc cacaggaacu ggauauucug aaaaccguaa aggaaaucac aggguuuuug     1080

cugauucagg cuuggccuga aaacaggacg gaccuccaug ccuuugagaa ccuagaaauc     1140

auacgcggca ggaccaagca acauggucag uuuucucuug cagucgucag ccugaacaua     1200

acauccuugg gauuacgcuc ccucaaggag auaagugaug gagaugugau aauuucagga     1260

aacaaaaauu ugugcuaugc aaauacaaua aacuggaaaa aacuguuugg gaccuccggu     1320

cagaaaacca aaauuauaag caacagaggu gaaaacagcu gcaaggccac aggccagguc     1380

ugccaugccu ugugcucccc cgagggcugc uggggcccgg agcccaggga cugcgucucu     1440

ugccggaaug ucagccgagg cagggaaugc guggacaagu gcaaccuucu ggagggugag     1500

ccaagggagu uuguggagaa cucugagugc auacagugcc acccagagug ccugccucag     1560

gccaugaaca ucaccugcac aggacgggga ccagacaacu guauccagug ugcccacuac     1620

auugacggcc cccacugcgu caagaccugc ccggcaggag ucaugggaga aaacaacacc     1680

cuggucugga aguacgcaga cgccggccau gugugccacc ugugccaucc aaacugcacc     1740

uacggaugca cugggccagg ucuugaaggc uguccaacga augggccuaa gaucccgucc     1800

aucgccacug ggaugguggg ggcccuccuc uugcugcugg ugguggcccu ggggaucggc     1860

cucuucaugc gaaggcgcca caucguucgg aagcgcacgc ugcggaggcu gcugcaggag     1920

agggagcuug uggagccucu uacacccagu ggagaagcuc ccaaccaagc ucucuugagg     1980

aucuugaagg aaacugaauu caaaaagauc aaagugcugg gcuccggugc guucggcacg     2040

guguauaagg gacucuggau cccagaaggu gagaaaguua aaauucccgu cgcuaucaag     2100

gaauuaagag aagcaacauc uccgaaagcc aacaaggaaa uccucgauga agccuacgug     2160

auggccagcg uggacaaccc ccacgugugc cgccugcugg gcaucugccu caccuccacc     2220

gugcagcuca ucacgcagcu caugcccuuc ggcugccucc uggacuaugu ccgggaacac     2280

aaagacaaua uuggcuccca guaccugcuc aacuggugug ugcagaucgc aaagggcaug     2340

aacuacuugg aggaccgucg cuuggugcac cgcgaccugg cagccaggaa cguacuggug     2400

aaaacaccgc agcaugucaa gaucacagau uuugggcugg ccaaacugcu gggugcggaa     2460

gagaaagaau accaugcaga aggaggcaaa gugccuauca aguggauggc auuggaauca     2520

auuuuacaca gaaucuauac ccaccagagu gaugucugga gcuacggggu gaccguuugg     2580

gaguugauga ccuuuggauc caagccauau gacggaaucc cugccagcga gaucuccucc     2640

auccuggaga aaggagaacg ccucccucag ccacccauau guaccaucga ugucuacaug     2700

aucaugguca agugcuggau gauagacgca gauagucgcc caaaguuccg ugaguugauc     2760

aucgaauucu ccaaaauggc ccgagacccc cagcgcuacc uugucauuca gggggaugaa     2820

agaaugcauu ugccaagucc uacagacucc aacuucuacc gugcccugau ggaugaagaa     2880

gacauggacg acguggugga ugccgacgag uaccucaucc cacagcaggg cuucuucagc     2940

agccccucca cgucacggac uccccuccug agcucucuga gugcaaccag caacaauucc     3000

accguggcuu gcauugauag aaaugggcug caaagcuguc ccaucaagga agacagcuuc     3060

uugcagcgau acagcucaga ccccacaggc gccuugacug aggacagcau agacgacacc     3120

uuccucccag ugccugguga guggcuuguc uggaaacagu ccugcuccuc aaccuccucg     3180

acccacucag cagcagccag ucuccagugu ccaagccagg ugcucccucc agcaucucca     3240

gagggggaaa caguggcaga uuugcagaca caguga                               3276


<210>  1387
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__AAH94761

<400>  1387
augcgcccca gcggcaccgc cggggccgcg cugcucgccc ugcuggccgc ccucugcccc       60

gccucccggg cgcuggagga gaagaaggug ugccagggca ccagcaacaa gcugacgcag      120

cucgggaccu ucgaggacca cuuccugucc cugcagcgca uguucaacaa cugcgagguc      180

gugcucggca accuggagau caccuacgug cagcggaacu acgaccugag cuuccucaag      240

accauccagg aggucgccgg guacgugcug aucgcccuga acacggugga gcgcaucccc      300

cucgagaacc ugcagaucau ccggggcaac auguacuacg agaacuccua cgcccuggcg      360

guccucagca acuacgacgc caacaagacc ggccugaagg agcugcccau gcgcaaccuc      420

caggggcaga agugcgaccc cuccugcccg aacggcagcu gcuggggcgc cggggaggag      480

aacugccaga agcugaccaa gaucaucugc gcccagcagu gcuccgggcg gugccgcggc      540

aagagccccu ccgacugcug ccacaaccag ugcgccgcgg gcugcaccgg gccccgggag      600

agcgacugcc uggugugccg caaguuccgg gacgaggcca cgugcaagga cacgugcccg      660

ccccucaugc uguacaaccc caccaccuac cagauggacg ugaaccccga gggcaaguac      720

uccuucgggg cgaccugcgu caagaagugc ccccgcaacu acguggugac cgaccacggc      780

agcugcgucc gggccugcgg cgccgacucc uacgagaugg aggaggacgg ggugcgcaag      840

ugcaagaagu gcgagggccc gugccggaag gugugcaacg ggaucggcau cggggaguuc      900

aaggacagcc uguccaucaa cgccaccaac aucaagcacu ucaagaacug caccagcauc      960

uccggcgacc uccacauccu gcccgucgcc uuccgcggcg acagcuucac gcacaccccg     1020

ccccuggacc cccaggagcu cgacauccug aagaccguga aggagaucac cggguuccug     1080

cucauccagg ccuggcccga gaaccggacg gaccugcacg ccuucgagaa ccuggagauc     1140

auccgcggcc ggaccaagca gcacgggcag uucagccucg ccguggucuc ccugaacauc     1200

accagccugg gccuccgcuc ccugaaggag aucagcgacg gggacgugau caucuccggc     1260

aacaagaacc ugugcuacgc gaacaccauc aacuggaaga agcuguucgg cacgagcggg     1320

cagaagacca agaucaucuc caaccggggc gagaacagcu gcaaggccac cggccaggug     1380

ugccacgccc ugugcucccc cgaggggugc ugggggcccg agccgcgcga cugcgucagc     1440

ugccgcaacg ugucccgggg ccgcgagugc guggacaagu gcaaccugcu cgagggcgag     1500

ccccgggagu ucgucgagaa cagcgagugc auccagugcc accccgagug ccugccccag     1560

gccaugaaca ucacgugcac cgggcgcggc ccggacaacu gcauccagug cgcccacuac     1620

aucgacgggc cccacugcgu gaagaccugc cccgcgggcg ucaugggcga gaacaacacc     1680

cuggugugga aguacgccga cgccgggcac gugugccacc ucugccaccc caacugcacc     1740

uacggcugca cggggccggg ccuggagggg ugccccacca acggccccaa gaucccgucc     1800

aucgccaccg gcauggucgg ggcgcugcug cuccugcugg ugguggcccu cggcaucggg     1860

cuguucaugc ggcgccggca caucguccgc aagcggaccc ugcgccggcu ccugcaggag     1920

cgcgagcugg uggagccccu cacgcccagc ggcgaggccc ccaaccaggc ccugcugcgg     1980

auccucaagg agaccgaguu caagaagauc aaggugcugg gguccggcgc cuucggcacc     2040

gucuacaagg ggcuguggau cccggagggc gagaagguga agauccccgu ggcgaucaag     2100

gagcuccgcg aggccaccag ccccaaggcc aacaaggaga uccuggacga ggccuacguc     2160

auggccuccg uggacaaccc ccacgugugc cggcugcucg ggaucugccu gaccagcacg     2220

guccagcuga ucacccagcu caugccguuc ggcugccugc uggacuacgu gcgcgagcac     2280

aaggacaaca ucggguccca guaccuccug aacuggugcg ugcagaucgc gaagggcaug     2340

aacuaccugg aggaccggcg ccucguccac cgggaccugg ccgcccgcaa cgugcuggug     2400

aagacgcccc agcacgucaa gaucaccgac uucggccucg ccaagcugcu gggggccgag     2460

gagaaggagu accacgcgga gggcgggaag gugcccauca aguggauggc ccucgagagc     2520

auccugcacc gcaucuacac ccaccagagc gacguguggu ccuacggcgu caccgugugg     2580

gagcugauga ccuucgggag caagcccuac gacggcaucc cggccuccga gaucagcucc     2640

auccucgaga agggcgagcg gcugccccag ccgcccaucu gcaccaucga cguguacaug     2700

aucaugguca agugcuggau gaucgacgcc gacagccgcc ccaaguuccg ggagcugauc     2760

aucgaguucu ccaagauggc gcgcgacccc cagcgguacc ucgugaucca gggggacgag     2820

cgcaugcacc uccccagccc cacggacucc aacuucuacc gggcccugau ggacgaggag     2880

gacauggacg acguggucga cgccgacgag uaccucaucc cgcagcaggg cuucuucagc     2940

ucccccagca ccucccgcac gccccugcug agcucccuca gcgccaccuc caacaacagc     3000

accguggccu gcaucgaccg gaacgggcug cagagcugcc ccaucaagga ggacuccuuc     3060

cugcagcgcu acagcuccga cccgaccggc gcgcucaccg aggacagcau cgacgacacc     3120

uuccugcccg ugcccggcga guggcugguc uggaagcagu ccugcagcuc cacgagcucc     3180

acccacagcg ccgccgccuc ccuccagugc ccgagccagg ugcugccgcc cgccuccccc     3240

gagggggaga ccguggcgga ccugcagacc caguga                               3276


<210>  1388
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__AAH94761

<400>  1388
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagguc ugccagggca ccuccaacaa gcucacccag      120

cucggcaccu ucgaggacca cuuccucucc cuccagcgca uguucaacaa cugcgagguc      180

guccucggca accucgagau caccuacguc cagcgcaacu acgaccucuc cuuccucaag      240

accauccagg aggucgccgg cuacguccuc aucgcccuca acaccgucga gcgcaucccc      300

cucgagaacc uccagaucau ccgcggcaac auguacuacg agaacuccua cgcccucgcc      360

guccucucca acuacgacgc caacaagacc ggccucaagg agcuccccau gcgcaaccuc      420

cagggccaga agugcgaccc cuccugcccc aacggcuccu gcuggggcgc cggcgaggag      480

aacugccaga agcucaccaa gaucaucugc gcccagcagu gcuccggccg cugccgcggc      540

aagucccccu ccgacugcug ccacaaccag ugcgccgccg gcugcaccgg cccccgcgag      600

uccgacugcc ucgucugccg caaguuccgc gacgaggcca ccugcaagga caccugcccc      660

ccccucaugc ucuacaaccc caccaccuac cagauggacg ucaaccccga gggcaaguac      720

uccuucggcg ccaccugcgu caagaagugc ccccgcaacu acgucgucac cgaccacggc      780

uccugcgucc gcgccugcgg cgccgacucc uacgagaugg aggaggacgg cguccgcaag      840

ugcaagaagu gcgagggccc cugccgcaag gucugcaacg gcaucggcau cggcgaguuc      900

aaggacuccc ucuccaucaa cgccaccaac aucaagcacu ucaagaacug caccuccauc      960

uccggcgacc uccacauccu ccccgucgcc uuccgcggcg acuccuucac ccacaccccc     1020

ccccucgacc cccaggagcu cgacauccuc aagaccguca aggagaucac cggcuuccuc     1080

cucauccagg ccuggcccga gaaccgcacc gaccuccacg ccuucgagaa ccucgagauc     1140

auccgcggcc gcaccaagca gcacggccag uucucccucg ccgucgucuc ccucaacauc     1200

accucccucg gccuccgcuc ccucaaggag aucuccgacg gcgacgucau caucuccggc     1260

aacaagaacc ucugcuacgc caacaccauc aacuggaaga agcucuucgg caccuccggc     1320

cagaagacca agaucaucuc caaccgcggc gagaacuccu gcaaggccac cggccagguc     1380

ugccacgccc ucugcucccc cgagggcugc uggggccccg agccccgcga cugcgucucc     1440

ugccgcaacg ucucccgcgg ccgcgagugc gucgacaagu gcaaccuccu cgagggcgag     1500

ccccgcgagu ucgucgagaa cuccgagugc auccagugcc accccgagug ccucccccag     1560

gccaugaaca ucaccugcac cggccgcggc cccgacaacu gcauccagug cgcccacuac     1620

aucgacggcc cccacugcgu caagaccugc cccgccggcg ucaugggcga gaacaacacc     1680

cucgucugga aguacgccga cgccggccac gucugccacc ucugccaccc caacugcacc     1740

uacggcugca ccggccccgg ccucgagggc ugccccacca acggccccaa gauccccucc     1800

aucgccaccg gcauggucgg cgcccuccuc cuccuccucg ucgucgcccu cggcaucggc     1860

cucuucaugc gccgccgcca caucguccgc aagcgcaccc uccgccgccu ccuccaggag     1920

cgcgagcucg ucgagccccu cacccccucc ggcgaggccc ccaaccaggc ccuccuccgc     1980

auccucaagg agaccgaguu caagaagauc aagguccucg gcuccggcgc cuucggcacc     2040

gucuacaagg gccucuggau ccccgagggc gagaagguca agauccccgu cgccaucaag     2100

gagcuccgcg aggccaccuc ccccaaggcc aacaaggaga uccucgacga ggccuacguc     2160

auggccuccg ucgacaaccc ccacgucugc cgccuccucg gcaucugccu caccuccacc     2220

guccagcuca ucacccagcu caugcccuuc ggcugccucc ucgacuacgu ccgcgagcac     2280

aaggacaaca ucggcuccca guaccuccuc aacuggugcg uccagaucgc caagggcaug     2340

aacuaccucg aggaccgccg ccucguccac cgcgaccucg ccgcccgcaa cguccucguc     2400

aagacccccc agcacgucaa gaucaccgac uucggccucg ccaagcuccu cggcgccgag     2460

gagaaggagu accacgccga gggcggcaag guccccauca aguggauggc ccucgagucc     2520

auccuccacc gcaucuacac ccaccagucc gacgucuggu ccuacggcgu caccgucugg     2580

gagcucauga ccuucggcuc caagcccuac gacggcaucc ccgccuccga gaucuccucc     2640

auccucgaga agggcgagcg ccucccccag ccccccaucu gcaccaucga cgucuacaug     2700

aucaugguca agugcuggau gaucgacgcc gacucccgcc ccaaguuccg cgagcucauc     2760

aucgaguucu ccaagauggc ccgcgacccc cagcgcuacc ucgucaucca gggcgacgag     2820

cgcaugcacc uccccucccc caccgacucc aacuucuacc gcgcccucau ggacgaggag     2880

gacauggacg acgucgucga cgccgacgag uaccucaucc cccagcaggg cuucuucucc     2940

ucccccucca ccucccgcac cccccuccuc uccucccucu ccgccaccuc caacaacucc     3000

accgucgccu gcaucgaccg caacggccuc caguccugcc ccaucaagga ggacuccuuc     3060

cuccagcgcu acuccuccga ccccaccggc gcccucaccg aggacuccau cgacgacacc     3120

uuccuccccg uccccggcga guggcucguc uggaagcagu ccugcuccuc caccuccucc     3180

acccacuccg ccgccgccuc ccuccagugc cccucccagg uccucccccc cgccuccccc     3240

gagggcgaga ccgucgccga ccuccagacc caguga                               3276


<210>  1389
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__AAH94761

<400>  1389
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagug ugucagggaa caucuaacaa gcugacucaa      120

cuagguacgu ucgaggacca cuuucucuca cugcagcgga uguucaauaa cugcgaaguc      180

guucuuggca aucuggagau caccuacgug cagcgcaacu augauuugag uuuucucaaa      240

acaauucagg aaguagccgg guacgugcug auagcucuga auacugucga gcgaauccca      300

cucgagaacu uacaaauuau ccguggaaau auguauuacg aaaacagcua ugcacuggcc      360

gugcuuucca auuacgacgc uaacaagacc ggcuugaaag agcugccgau gagaaaucua      420

cagggucaga agugugaucc cucuugcccu aacgggucgu guuggggagc cggcgaagag      480

aauugccaga agcucacaaa aauuaucugu gcgcaacagu gcucagggag gugucggggc      540

aagagcccaa gugacugcug ucauaaccag ugcgcagccg gaugcaccgg uccccgcgag      600

uccgauuguc ugguuugcag aaaauucagg gacgaagcua cuuguaagga uacaugcccu      660

ccacuuaugc uguauaaucc caccacguac cagauggacg ugaacccuga gggcaaauac      720

ucuuuugggg ccacuugugu caagaagugc ccacggaacu augugguaac cgaucacgga      780

agcuguguuc gcgcaugcgg cgcugacucc uacgaaaugg aggaagaugg ugugcgaaaa      840

uguaagaaau gcgaggggcc guguagaaag gucugcaaug gaauaggcau cggcgaguuc      900

aaagacucau ugaguauuaa cgccacaaau aucaagcauu uuaaaaacug cacuagcauu      960

ucuggggauc uccacauccu gcccguggcg uucaggggag acuccuuuac ccauacaccu     1020

ccauuagacc cccaagaacu ggauauacuc aagaccguga aggagauuac ggguuuccuu     1080

cugauccagg ccuggccuga aaaucggacu gacuugcacg cauuugagaa ccuagaaauu     1140

auccguggcc gcacaaaaca gcacgggcaa uucucacugg cugucguuag ccucaauauc     1200

accagucugg gacuuagauc ucugaaggag auuuccgaug gcgacgugau aaucagcggu     1260

aacaaaaauu uguguuaugc caacacuauu aauuggaaga aacucuuugg gacaucgggc     1320

cagaagacca agaucauauc uaacagggga gaaaauuccu gcaaagcuac gggccaggua     1380

ugucaugccc ugugcucacc agaggggugu uggggacccg agccgcggga uugcgugagu     1440

ugucgaaacg ucagccgcgg uagagaaugc guggacaagu guaauuuacu ggagggcgaa     1500

ccuagggagu ucguugagaa cuccgaaugc auucaguguc accccgagug ccuaccacaa     1560

gcaaugaaca uuaccugcac agggcgggga ccugauaauu guauccagug cgcccauuac     1620

aucgacggcc cccacugugu gaaaacuugc ccagcuggug ucauggggga aaacaauacc     1680

cucgugugga aguaugcgga ugcaggccac guaugucauc ugugccaccc caacuguaca     1740

uacggaugca cuggcccugg gcuugaggga uguccaacca augguccgaa aauccccucu     1800

auugccacag gcaugguugg ggcuuugcug cuccugcuug uggucgcccu gggaauaggc     1860

uuguucaugc gcagaaggca uaucgugcgu aagcggaccc uccgaagacu guuacaggag     1920

agggaacugg ucgagccucu aacuccaagc ggugaagcac ccaaccaggc ccuccugcgc     1980

auucuuaagg agacggaauu uaaaaagauc aaaguguugg ggucaggcgc uuucggaaca     2040

guuuauaagg gccuguggau cccugagggg gagaaaguga agauuccagu agccauaaag     2100

gaacuccggg aggcaaccag ucccaaagcg aauaaggaaa uccuggacga ggcuuacguc     2160

auggccuccg uggauaaccc gcacguuugc agauuacugg gaauuugucu uacuagcacc     2220

gugcaauuga ucacacagcu caugccuuuu ggcugccugc uagacuacgu cagggaacau     2280

aaagacaaua uugguucuca guaucugcuc aacuggugcg ugcagaucgc aaaggggaug     2340

aauuaccugg aggaucgccg acuuguacac cgggacuugg ccgcucguaa cgugcugguu     2400

aaaaccccac aacacgucaa gauaacugau uucggauuag ccaaacuccu gggcgcagag     2460

gaaaaggagu aucaugcuga agguggcaag gugcccauca aauggauggc ccuugaguca     2520

auucugcaca gaaucuacac acaucagagu gacgugugga gcuauggggu cacgguuugg     2580

gaauugauga ccuuuggauc caagccuuac gauggcauuc ccgcgucuga gaucucgagc     2640

auacucgaga aaggggaaag gcugccacag ccucccauuu guacuaucga cguguauaug     2700

auuaugguga agugcuggau gaucgaugcc gacucccgcc caaaauuccg ggagcuaaua     2760

aucgaauuuu caaagauggc uagagauccg cagagguacc ugguaauuca aggagacgag     2820

cgaaugcacc ucccuagucc cacagauucu aauuucuacc gcgcacugau ggacgaggaa     2880

gauauggacg acgucgugga ugccgacgag uaucuuaucc cacagcaggg cuuuuucagc     2940

ucccccucaa ccagccggac accuuugcug ucuuccuuaa gugcuacuag caacaauucu     3000

accguugccu guauugauag aaacggucuc caauccugcc caaucaagga agacucauuu     3060

cugcagaggu acaguagcga ucccacgggg gcacuuaccg aggacucgau agaugacaca     3120

uuccugccug ugccgggaga auggcuaguc uggaaacagu ccuguucuag cacuucaagu     3180

acccacuccg cggccgcuuc ucuccagugc ccaagccaag ugcugccccc ugccucccca     3240

gagggcgaga caguugcaga uuugcagacu caguga                               3276


<210>  1390
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__AAH94761

<400>  1390
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaaggug ugccagggca ccagcaacaa gcugacccag      120

cugggcaccu ucgaggacca cuuccugagc cugcagagaa uguucaacaa cugcgaggug      180

gugcugggca accuggagau caccuacgug cagagaaacu acgaccugag cuuccugaag      240

accauccagg agguggccgg cuacgugcug aucgcccuga acaccgugga gagaaucccc      300

cuggagaacc ugcagaucau cagaggcaac auguacuacg agaacagcua cgcccuggcc      360

gugcugagca acuacgacgc caacaagacc ggccugaagg agcugcccau gagaaaccug      420

cagggccaga agugcgaccc cagcugcccc aacggcagcu gcuggggcgc cggcgaggag      480

aacugccaga agcugaccaa gaucaucugc gcccagcagu gcagcggcag augcagaggc      540

aagagcccca gcgacugcug ccacaaccag ugcgccgccg gcugcaccgg ccccagagag      600

agcgacugcc uggugugcag aaaguucaga gacgaggcca ccugcaagga caccugcccc      660

ccccugaugc uguacaaccc caccaccuac cagauggacg ugaaccccga gggcaaguac      720

agcuucggcg ccaccugcgu gaagaagugc cccagaaacu acguggugac cgaccacggc      780

agcugcguga gagccugcgg cgccgacagc uacgagaugg aggaggacgg cgugagaaag      840

ugcaagaagu gcgagggccc cugcagaaag gugugcaacg gcaucggcau cggcgaguuc      900

aaggacagcc ugagcaucaa cgccaccaac aucaagcacu ucaagaacug caccagcauc      960

agcggcgacc ugcacauccu gcccguggcc uucagaggcg acagcuucac ccacaccccc     1020

ccccuggacc cccaggagcu ggacauccug aagaccguga aggagaucac cggcuuccug     1080

cugauccagg ccuggcccga gaacagaacc gaccugcacg ccuucgagaa ccuggagauc     1140

aucagaggca gaaccaagca gcacggccag uucagccugg ccguggugag ccugaacauc     1200

accagccugg gccugagaag ccugaaggag aucagcgacg gcgacgugau caucagcggc     1260

aacaagaacc ugugcuacgc caacaccauc aacuggaaga agcuguucgg caccagcggc     1320

cagaagacca agaucaucag caacagaggc gagaacagcu gcaaggccac cggccaggug     1380

ugccacgccc ugugcagccc cgagggcugc uggggccccg agcccagaga cugcgugagc     1440

ugcagaaacg ugagcagagg cagagagugc guggacaagu gcaaccugcu ggagggcgag     1500

cccagagagu ucguggagaa cagcgagugc auccagugcc accccgagug ccugccccag     1560

gccaugaaca ucaccugcac cggcagaggc cccgacaacu gcauccagug cgcccacuac     1620

aucgacggcc cccacugcgu gaagaccugc cccgccggcg ugaugggcga gaacaacacc     1680

cuggugugga aguacgccga cgccggccac gugugccacc ugugccaccc caacugcacc     1740

uacggcugca ccggccccgg ccuggagggc ugccccacca acggccccaa gauccccagc     1800

aucgccaccg gcaugguggg cgcccugcug cugcugcugg ugguggcccu gggcaucggc     1860

cuguucauga gaagaagaca caucgugaga aagagaaccc ugagaagacu gcugcaggag     1920

agagagcugg uggagccccu gacccccagc ggcgaggccc ccaaccaggc ccugcugaga     1980

auccugaagg agaccgaguu caagaagauc aaggugcugg gcagcggcgc cuucggcacc     2040

guguacaagg gccuguggau ccccgagggc gagaagguga agauccccgu ggccaucaag     2100

gagcugagag aggccaccag ccccaaggcc aacaaggaga uccuggacga ggccuacgug     2160

auggccagcg uggacaaccc ccacgugugc agacugcugg gcaucugccu gaccagcacc     2220

gugcagcuga ucacccagcu gaugcccuuc ggcugccugc uggacuacgu gagagagcac     2280

aaggacaaca ucggcagcca guaccugcug aacuggugcg ugcagaucgc caagggcaug     2340

aacuaccugg aggacagaag acuggugcac agagaccugg ccgccagaaa cgugcuggug     2400

aagacccccc agcacgugaa gaucaccgac uucggccugg ccaagcugcu gggcgccgag     2460

gagaaggagu accacgccga gggcggcaag gugcccauca aguggauggc ccuggagagc     2520

auccugcaca gaaucuacac ccaccagagc gacgugugga gcuacggcgu gaccgugugg     2580

gagcugauga ccuucggcag caagcccuac gacggcaucc ccgccagcga gaucagcagc     2640

auccuggaga agggcgagag acugccccag ccccccaucu gcaccaucga cguguacaug     2700

aucaugguga agugcuggau gaucgacgcc gacagcagac ccaaguucag agagcugauc     2760

aucgaguuca gcaagauggc cagagacccc cagagauacc uggugaucca gggcgacgag     2820

agaaugcacc ugcccagccc caccgacagc aacuucuaca gagcccugau ggacgaggag     2880

gacauggacg acguggugga cgccgacgag uaccugaucc cccagcaggg cuucuucagc     2940

agccccagca ccagcagaac cccccugcug agcagccuga gcgccaccag caacaacagc     3000

accguggccu gcaucgacag aaacggccug cagagcugcc ccaucaagga ggacagcuuc     3060

cugcagagau acagcagcga ccccaccggc gcccugaccg aggacagcau cgacgacacc     3120

uuccugcccg ugcccggcga guggcuggug uggaagcaga gcugcagcag caccagcagc     3180

acccacagcg ccgccgccag ccugcagugc cccagccagg ugcugccccc cgccagcccc     3240

gagggcgaga ccguggccga ccugcagacc caguga                               3276


<210>  1391
<211>  3276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__AAH94761

<400>  1391
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagug ugucagggaa caucuaacaa gcugacgcaa      120

cuuggcaccu ucgaggacca cuuucugagc cuccagcgca uguucaauaa cugcgaaguc      180

guucugggga aucuggagau cacauacgug cagagaaacu augaucucuc cuuucugaaa      240

accauucagg aaguggccgg auacguccuu aucgcucuga auacagugga gcggauuccg      300

cucgagaacc ugcaaaucau ucgcggcaau auguauuacg aaaacucuua ugcccuugcg      360

guucugagca auuacgacgc caacaagacc gggcucaaag agcugcccau gagaaaucug      420

cagggacaga agugugaucc uuccugcccc aacggcucuu guuggggcgc uggggaagag      480

aauugccaga agcucacaaa aaucaucugu gcccaacagu gcagcggacg gugucgcggc      540

aaguccccua gcgacugcug ucauaaccag ugcgcugccg ggugcaccgg acccagagag      600

ucugauuguc uggugugccg gaaauuccgc gacgaagcga cguguaagga uaccugcccu      660

ccgcuuaugc uguauaaucc cacaaccuac cagauggacg ucaacccuga gggcaaauac      720

uccuuugggg ccacaugugu gaagaagugc cccagaaacu auguugugac cgaucacgga      780

agcugugucc gggcuugcgg cgccgacucu uacgaaaugg aggaagaugg cgugcgcaaa      840

uguaagaaau gcgaggggcc uuguagaaag gugugcaaug gaauuggcau cggggaguuc      900

aaagacuccc ucagcauuaa cgcuacgaau aucaagcauu uuaaaaacug cacaucuauu      960

uccggagauc ugcacauccu ucccgucgcc uuccggggcg acagcuuuac ccauacaccg     1020

ccucuggacc cccaagaacu cgauauucug aagaccguua aggagaucac cggguuccug     1080

cucauccagg ccuggccuga aaaucgcaca gaccugcacg cuuuugagaa ccuugaaauu     1140

aucagaggac ggacgaaaca gcacggccaa uucucccugg cggugguguc ucucaauauu     1200

accagccugg gccuuagauc ccugaaggag aucagcgaug gggacgucau uaucucugga     1260

aacaaaaauc ucuguuaugc caacacaauc aauuggaaga aacuguuugg caccuccggg     1320

cagaagacaa agauuaucag caaccgcgga gaaaauucuu gcaaagcuac cggccaggug     1380

ugucaugccc ugugcagccc cgaggggugu uggggccccg agccucggga uugcguuucc     1440

uguagaaacg ugucucgcgg acgggaaugc gucgacaagu guaaucuccu ggagggcgaa     1500

ccgagagagu ucguggagaa cagcgaaugc auucaguguc accccgagug ccuuccucaa     1560

gccaugaaca ucacgugcac agggcgcgga cccgauaauu guauucagug cgcucauuac     1620

aucgacggcc cucacugugu uaaaaccugc cccgccgggg ugaugggaga aaacaauacc     1680

cuggucugga aguaugcgga ugcuggccac gugugucauc ucugccaccc gaacuguaca     1740

uacgggugca ccggcccugg acuggagggc ugucccacaa augggccuaa aauccccucc     1800

auugccacgg gaauggucgg cgcccugcuu cuccugcugg ugguugcucu cgggaucgga     1860

cuguucaugc ggagacgcca uauugugcgg aagagaaccc uucgccggcu gcuccaggag     1920

agagaacugg ucgagccucu gacacccagc ggcgaagccc cgaaccaggc ccuucuccgg     1980

auccugaagg agaccgaauu uaaaaagauu aaagugcugg ggucuggcgc uuucggaaca     2040

guuuauaagg gccucuggau cccugagggg gagaaaguga agauucccgu cgcgaucaag     2100

gaacugcgcg aggccaccuc ccccaaagcu aauaaggaaa uccuugacga ggccuacgug     2160

auggcuagcg uggauaaccc ucacguuugc agacugcucg gaauuugucu gacgucuacc     2220

guccaacuga ucacacagcu uaugccguuu ggcugccucc uggacuacgu gcgggaacau     2280

aaagacaaua uuggguccca guaucugcuc aacuggugcg ugcagaucgc caagggaaug     2340

aauuaccugg aggauagacg ccuuguccac cgggaccugg cggccagaaa cgugcucguu     2400

aaaacacccc aacacgugaa gauuaccgau uucggccugg cuaaacugcu uggggccgag     2460

gaaaaggagu aucaugcuga aggcggaaag gucccuauca aauggauggc ccucgagagc     2520

auccugcacc gcauuuacac ccaucagucc gacguguggu cuuauggcgu uacggugugg     2580

gaacugauga cauuugggag caagcccuac gauggaaucc cugccuccga gauuucuagc     2640

auccucgaga aaggcgaaag acugccccag ccucccauuu guaccaucga cgucuauaug     2700

aucaugguga agugcuggau gauugaugcu gacucccggc cgaaauuccg cgagcuuauc     2760

auugaauuua gcaagauggc gagagauccu cagcgguacc ugguuaucca aggggacgag     2820

cgcaugcacc uccccucucc uacagauucc aauuucuaca gagcccugau ggacgaggaa     2880

gauauggacg acguggucga ugcugacgag uaucugauuc cccagcaggg auuuuucagc     2940

ucuccgucca ccagccggac cccucuucug ucuagccucu ccgccacaag caacaauucu     3000

acgguggccu guaucgaucg caacggccug caauccugcc ccaucaagga agacagcuuu     3060

cuccagagau acuccucuga uccuaccggc gcucugacag aggacagcau ugaugacacc     3120

uuccuucccg ugcccgggga auggcugguc uggaaacagu ccuguucuag cacauccucu     3180

acccacagcg ccgcggcuuc ccuccagugc ccuagccaag uucugccgcc cgccucuccu     3240

gagggagaga cgguggccga ucugcagaca caguga                               3276


<210>  1392
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__Q8NDU8

<400>  1392

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Lys Gly 
            20                  25                  30          


Val Ser Arg Arg Leu Pro Arg Arg Pro Arg Ile Ala Pro Arg Thr Pro 
        35                  40                  45              


Gln Pro Ala Gln Pro Arg Thr Gly Ala Pro Ala Arg Ala Arg Ala Pro 
    50                  55                  60                  


Ala Arg Pro Phe Leu Phe Pro 
65                  70      


<210>  1393
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGFR__Homo_sapiens__CAA34902

<400>  1393
augcgacccu ccgggacggc cggggcagcg cuccuggcgc ugcuggcugc gcucugcccg       60

gcgagucggg cucuggagga aaagaaaggu aagggcgugu cucgccggcu cccgcgccgc      120

ccccggaucg cgccccggac cccgcagccc gcccaaccgc gcaccggcgc accggcucgc      180

gcccgcgccc ccgcccgucc uuuccuguuu ccuuga                                216


<210>  1394
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGFR__Homo_sapiens__CAA34902

<400>  1394
augcgcccca gcggcaccgc cggggccgcg cugcucgccc ugcuggccgc ccucugcccg       60

gccucccggg cgcuggagga gaagaagggc aaggggguga gccgccggcu gccccgccgg      120

ccccgcaucg cgccccggac cccgcagccc gcccagcccc gcacgggcgc ccccgcccgg      180

gcccgcgccc cggcccggcc cuuccucuuc cccuga                                216


<210>  1395
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGFR__Homo_sapiens__CAA34902

<400>  1395
augcgccccu ccggcaccgc cggcgccgcc cuccucgccc uccucgccgc ccucugcccc       60

gccucccgcg cccucgagga gaagaagggc aagggcgucu cccgccgccu cccccgccgc      120

ccccgcaucg ccccccgcac cccccagccc gcccagcccc gcaccggcgc ccccgcccgc      180

gcccgcgccc ccgcccgccc cuuccucuuc cccuga                                216


<210>  1396
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGFR__Homo_sapiens__CAA34902

<400>  1396
augagaccca gcggcaccgc cggggcugca cugcucgccc uucuggcggc uuugugcccu       60

gccuccaggg cauuagagga aaagaaagga aagggugugu cucggcgccu gccacgacgu      120

ccgagaaucg cccccaggac accucagcca gcucaacccc ggacuggcgc cccugcacgc      180

gcuagagccc cagcgaggcc cuuccuauuu ccuuga                                216


<210>  1397
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGFR__Homo_sapiens__CAA34902

<400>  1397
augagaccca gcggcaccgc cggcgccgcc cugcuggccc ugcuggccgc ccugugcccc       60

gccagcagag cccuggagga gaagaagggc aagggcguga gcagaagacu gcccagaaga      120

cccagaaucg cccccagaac cccccagccc gcccagccca gaaccggcgc ccccgccaga      180

gccagagccc ccgccagacc cuuccuguuc cccuga                                216


<210>  1398
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGFR__Homo_sapiens__CAA34902

<400>  1398
augagaccca gcggcaccgc cggggcugcc cugcucgcgc ugcuugcugc ccugugcccu       60

gccucccggg cucucgagga aaagaaagga aagggcgugu cucgcagacu gccgcggcgc      120

cccagaaucg ccccucggac accccagccu gcucaacccc gcacgggggc cccugcgaga      180

gcccgggcuc cggcccgccc cuuccuuuuu ccuuga                                216


<210>  1399
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EGLN3__Homo_sapiens__Q9H6Z9

<400>  1399

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


<210>  1400
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EGLN3__Homo_sapiens__AAH10992

<400>  1400
augccccugg gacacaucau gaggcuggac cuggagaaaa uugcccugga guacaucgug       60

cccugucugc acgagguggg cuucugcuac cuggacaacu uccugggcga gguggugggc      120

gacugcgucc uggagcgcgu caagcagcug cacugcaccg gggcccugcg ggacggccag      180

cuggcggggc cgcgcgccgg cgucuccaag cgacaccugc ggggcgacca gaucacgugg      240

aucgggggca acgaggaggg cugcgaggcc aucagcuucc uccugucccu caucgacagg      300

cugguccucu acugcgggag ccggcugggc aaauacuacg ucaaggagag gucuaaggca      360

augguggcuu gcuauccggg aaauggaaca gguuauguuc gccacgugga caaccccaac      420

ggugaugguc gcugcaucac cugcaucuac uaucugaaca agaauuggga ugccaagcua      480

caugguggga uccugcggau auuuccagag gggaaaucau ucauagcaga uguggagccc      540

auuuuugaca gacuccuguu cuucugguca gaucguagga acccacacga agugcagccc      600

ucuuacgcaa ccagauaugc uaugacuguc ugguacuuug augcugaaga aagggcagaa      660

gccaaaaaga aauucaggaa uuuaacuagg aaaacugaau cugcccucac ugaagacuga      720


<210>  1401
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EGLN3__Homo_sapiens__AAH10992

<400>  1401
augccccugg gccacaucau gcgccucgac cuggagaaga ucgcccugga guacaucgug       60

ccgugccucc acgaggucgg guucugcuac cuggacaacu uccugggcga gguggugggg      120

gacugcgucc ucgagcgggu gaagcagcug cacugcaccg gcgcccugcg cgacgggcag      180

cucgcgggcc cccgggccgg cgugagcaag cgccaccucc gcggggacca gaucaccugg      240

aucggcggga acgaggaggg cugcgaggcc aucuccuucc ugcucagccu gaucgaccgg      300

cugguccucu acugcggguc ccggcugggc aaguacuacg ugaaggagcg cagcaaggcc      360

augguggccu gcuaccccgg caacgggacg ggcuacgucc ggcacgugga caaccccaac      420

ggggacggcc gcugcaucac gugcaucuac uaccugaaca agaacuggga cgcgaagcuc      480

cacggcggga uccugcggau cuucccggag ggcaaguccu ucaucgccga cguggagccc      540

aucuucgacc gccugcuguu cuucuggagc gaccggcgca acccccacga gguccagccc      600

uccuacgcca cccgguacgc caugaccgug ugguacuucg acgcggagga gcgcgccgag      660

gccaagaaga aguuccggaa ccugacccgc aagaccgaga gcgcccugac cgaggacuga      720


<210>  1402
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EGLN3__Homo_sapiens__AAH10992

<400>  1402
augccccucg gccacaucau gcgccucgac cucgagaaga ucgcccucga guacaucguc       60

cccugccucc acgaggucgg cuucugcuac cucgacaacu uccucggcga ggucgucggc      120

gacugcgucc ucgagcgcgu caagcagcuc cacugcaccg gcgcccuccg cgacggccag      180

cucgccggcc cccgcgccgg cgucuccaag cgccaccucc gcggcgacca gaucaccugg      240

aucggcggca acgaggaggg cugcgaggcc aucuccuucc uccucucccu caucgaccgc      300

cucguccucu acugcggcuc ccgccucggc aaguacuacg ucaaggagcg cuccaaggcc      360

auggucgccu gcuaccccgg caacggcacc ggcuacgucc gccacgucga caaccccaac      420

ggcgacggcc gcugcaucac cugcaucuac uaccucaaca agaacuggga cgccaagcuc      480

cacggcggca uccuccgcau cuuccccgag ggcaaguccu ucaucgccga cgucgagccc      540

aucuucgacc gccuccucuu cuucuggucc gaccgccgca acccccacga gguccagccc      600

uccuacgcca cccgcuacgc caugaccguc ugguacuucg acgccgagga gcgcgccgag      660

gccaagaaga aguuccgcaa ccucacccgc aagaccgagu ccgcccucac cgaggacuga      720


<210>  1403
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EGLN3__Homo_sapiens__AAH10992

<400>  1403
augccccugg gccacaucau gagacucgac cuugagaaga uugcccugga auacauagug       60

ccuugcuugc augaggucgg guucuguuau uuagauaacu uucugggaga aguugugggu      120

gacugcguac uagagagggu gaaacagcuc cacuguaccg gcgcucugcg ggaugggcaa      180

cuugcaggac cacgcgccgg cgucagcaag cgacaucugc guggugacca gaucacaugg      240

auugggggaa augaagaggg cugcgaggcg aucuccuucu ugcucucucu gauugauaga      300

cuggugcucu acuguggcuc aagguuaggg aaauauuacg uuaaggaacg gaguaaagcu      360

augguggccu gcuauccggg aaacgguacu ggcuacgucc gccacgugga caaucccaac      420

ggggauggaa gauguaucac gugcauauau uaccugaaua agaacuggga cgcaaaacuu      480

cauggcggua ucuugaggau uuuuccugag gggaaguccu ucaucgccga uguagaacca      540

auuuuugacc ggcugcuauu cuuuuggagc gaucgccgaa auccccacga gguucagccu      600

ucuuacgcua ccagauaugc aaugacagug ugguacuucg acgccgagga aagggcugag      660

gccaagaaaa aguuucggaa ccucacucgu aaaaccgaau cggcgcugac agaggauuga      720


<210>  1404
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EGLN3__Homo_sapiens__AAH10992

<400>  1404
augccccugg gccacaucau gagacuggac cuggagaaga ucgcccugga guacaucgug       60

cccugccugc acgagguggg cuucugcuac cuggacaacu uccugggcga gguggugggc      120

gacugcgugc uggagagagu gaagcagcug cacugcaccg gcgcccugag agacggccag      180

cuggccggcc ccagagccgg cgugagcaag agacaccuga gaggcgacca gaucaccugg      240

aucggcggca acgaggaggg cugcgaggcc aucagcuucc ugcugagccu gaucgacaga      300

cuggugcugu acugcggcag cagacugggc aaguacuacg ugaaggagag aagcaaggcc      360

augguggccu gcuaccccgg caacggcacc ggcuacguga gacacgugga caaccccaac      420

ggcgacggca gaugcaucac cugcaucuac uaccugaaca agaacuggga cgccaagcug      480

cacggcggca uccugagaau cuuccccgag ggcaagagcu ucaucgccga cguggagccc      540

aucuucgaca gacugcuguu cuucuggagc gacagaagaa acccccacga ggugcagccc      600

agcuacgcca ccagauacgc caugaccgug ugguacuucg acgccgagga gagagccgag      660

gccaagaaga aguucagaaa ccugaccaga aagaccgaga gcgcccugac cgaggacuga      720


<210>  1405
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EGLN3__Homo_sapiens__AAH10992

<400>  1405
augccccugg gccacaucau gagacucgac cuggagaaga uugcccuuga auacaucgug       60

ccuugccugc augaggucgg guucuguuau cucgauaacu uucugggaga aguugugggc      120

gacugcgugc uugagcgggu caaacagcug cacuguaccg gggcucuccg cgauggacaa      180

cuggccggcc cgagagcggg ggugagcaag cggcaucugc gcggagacca gauuacaugg      240

aucggcggca augaagaggg gugcgaggcu auuuccuucc uccugucucu uaucgauaga      300

cugguucucu acuguggaag ccggcugggc aaauauuacg ugaaggaacg cuccaaagcc      360

auggucgccu gcuaucccgg gaacggaacg ggcuacguga gacacguuga caauccuaac      420

ggggauggac gguguauuac cugcaucuau uaccuuaaua agaacuggga cgcuaagcug      480

cauggcggca uccuccgcau uuuucccgag gggaaaucuu ucaucgccga uguggaaccu      540

auuuuugaca gacugcuguu cuuuuggagc gaucggcgca auccccacga gguccagccu      600

uccuacgcua caagauaugc caugaccgug ugguacuucg acgcggagga acgggccgag      660

gcuaagaaaa aguuucgcaa ccucacaaga aaaaccgaau cugcccugac agaggauuga      720


<210>  1406
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ELF2/m__Homo_sapiens__B7Z720

<400>  1406

Met Ala Thr Ser Leu His Glu Gly Pro Thr Asn Gln Leu Asp Leu Leu 
1               5                   10                  15      


Ile Arg Ala Val Glu Ala Ser Val His Ser Ser Asn Ala His Cys Thr 
            20                  25                  30          


Asp Lys Thr Ile Glu Ala Ala Glu Ala Leu Leu His Met Glu Ser Pro 
        35                  40                  45              


Thr Cys Leu Arg Asp Ser Arg Ser Pro Glu Phe Ile His Ala Ala Met 
    50                  55                  60                  


Arg Pro Asp Val Ile Thr Glu Thr Val Val Glu Val Ser Thr Glu Glu 
65                  70                  75                  80  


Ser Glu Pro Met Asp Thr Ser Pro Ile Pro Thr Ser Pro Asp Ser His 
                85                  90                  95      


Glu Pro Met Lys Lys Lys Lys Val Gly Arg Lys Pro Lys Thr Gln Gln 
            100                 105                 110         


Ser Pro Ile Ser Asn Gly Ser Pro Glu Leu Gly Ile Lys Lys Lys Pro 
        115                 120                 125             


Arg Glu Gly Lys Gly Asn Thr Thr Tyr Leu Trp Glu Phe Leu Leu Asp 
    130                 135                 140                 


Leu Leu Gln Asp Lys Asn Thr Cys Pro Arg Tyr Ile Lys Trp Thr Gln 
145                 150                 155                 160 


Arg Glu Lys Gly Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Lys 
                165                 170                 175     


Leu Trp Gly Lys His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met 
            180                 185                 190         


Gly Arg Ala Leu Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val 
        195                 200                 205             


Glu Gly Gln Arg Leu Val Tyr Gln Phe Lys Asp Met Pro Lys Asn Ile 
    210                 215                 220                 


Val Val Ile Asp Asp Asp Lys Ser Glu Thr Cys Asn Glu Asp Leu Ala 
225                 230                 235                 240 


Gly Thr Thr Asp Glu Lys Ser Leu Glu Arg Val Ser Leu Ser Ala Glu 
                245                 250                 255     


Ser Leu Leu Lys Ala Ala Ser Ser Val Arg Ser Gly Lys Asn Ser Ser 
            260                 265                 270         


Pro Ile Asn Cys Ser Arg Ala Glu Lys Gly Val Ala Arg Val Val Asn 
        275                 280                 285             


Ile Thr Ser Pro Gly His Asp Ala Ser Ser Arg Ser Pro Thr Thr Thr 
    290                 295                 300                 


Ala Ser Val Ser Ala Thr Ala Ala Pro Arg Thr Val Arg Val Ala Met 
305                 310                 315                 320 


Gln Val Pro Val Val Met Thr Ser Leu Gly Gln Lys Ile Ser Thr Val 
                325                 330                 335     


Ala Val Gln Ser Val Asn Ala Gly Ala Pro Leu Ile Thr Ser Thr Ser 
            340                 345                 350         


Pro Thr Thr Ala Thr Ser Pro Lys Val Val Ile Gln Thr Ile Pro Thr 
        355                 360                 365             


Val Met Pro Ala Ser Thr Glu Asn Gly Asp Lys Ile Thr Met Gln Pro 
    370                 375                 380                 


Ala Lys Ile Ile Thr Ile Pro Ala Thr Gln Leu Ala Gln Cys Gln Leu 
385                 390                 395                 400 


Gln Thr Lys Ser Asn Leu Thr Gly Ser Gly Ser Ile Asn Ile Val Gly 
                405                 410                 415     


Thr Pro Leu Ala Val Arg Ala Leu Thr Pro Val Ser Ile Ala His Gly 
            420                 425                 430         


Thr Pro Val Met Arg Leu Ser Met Pro Thr Gln Gln Ala Ser Gly Gln 
        435                 440                 445             


Thr Pro Pro Arg Val Ile Ser Ala Val Ile Lys Gly Pro Glu Val Lys 
    450                 455                 460                 


Ser Glu Ala Val Ala Lys Lys Gln Glu His Asp Val Lys Thr Leu Gln 
465                 470                 475                 480 


Leu Val Glu Glu Lys Pro Ala Asp Gly Asn Lys Thr Val Thr His Val 
                485                 490                 495     


Val Val Val Ser Ala Pro Ser Ala Ile Ala Leu Pro Val Thr Met Lys 
            500                 505                 510         


Thr Glu Gly Leu Val Thr Cys Glu Lys 
        515                 520     


<210>  1407
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ELF2/m__Homo_sapiens__BAH13456

<400>  1407
auggcgacgu cucugcauga gggacccacg aaccagcugg aucugcucau ccgggccgug       60

gaagcaucag uucacagcag uaaugcacac uguacagaua agacaauuga agcugcugaa      120

gcccugcuuc auauggaauc uccuaccugc uugagggauu caagaagucc ugaauucauc      180

caugcugcua ugaggccaga ugucauuaca gaaacuguag uggagguguc aacugaagag      240

ucugaaccca uggauaccuc uccuauucca acaucaccag auagccauga accaaugaaa      300

aagaaaaaag uuggccguaa accaaagacc cagcaaucac caauuuccaa ugggucuccu      360

gaguuaggua uaaagaagaa accaagagaa ggaaaaggaa acacaaccua uuugugggag      420

uuucuuuuag aucuacuuca agauaaaaau acuuguccca gguauauuaa auggacucag      480

agagaaaaag gcauauucaa gcugguggau ucaaaggcug ucucuaagcu uuggggaaag      540

cauaagaaca aaccagacau gaacuaugaa accaugggac gagcuuugag auacuacuac      600

caaaggggaa uucuugcaaa gguugaagga cagaggcuug uauaucaguu caaggauaug      660

ccgaaaaaca uaguggucau agaugaugac aaaagugaaa ccuguaauga agauuuagca      720

ggaacuacug augaaaaauc auuagaacga gugucacugu cugcagaaag ucuccugaaa      780

gcagcauccu cuguucgcag uggaaaaaau ucauccccua uaaacugcuc cagagcagag      840

aaggguguag cuagaguugu gaauaucacu uccccugggc acgaugcuuc auccaggucu      900

ccuacuacca cugcaucugu gucagcaaca gcagcuccaa ggacaguucg uguggcaaug      960

cagguaccug uuguaaugac aucauugggu cagaaaauuu caacuguggc aguucaguca     1020

guuaaugcag gugcaccauu aauaaccagc acuaguccaa caacagcgac cucuccaaag     1080

guagucauuc agacaauccc uacugugaug ccagcuucua cugaaaaugg agacaaaauc     1140

accaugcagc cugccaaaau uauuaccauc ccagcuacac agcuugcaca gugucaacug     1200

cagacaaagu caaaucugac uggaucagga agcauuaaca uuguuggaac cccauuggcu     1260

gugagagcac uuaccccugu uucaauagcc caugguacac cuguaaugag acuaucaaug     1320

ccuacucagc aggcaucugg ccagacuccu ccucgaguua ucagugcagu cauaaagggg     1380

ccagagguua aaucggaagc aguggcaaaa aagcaagaac augaugugaa aacuuugcag     1440

cuaguagaag aaaaaccagc agauggaaau aagacaguga cccacguagu gguugucagu     1500

gcgccuucag cuauugcccu uccuguaacu augaaaacag aaggacuagu gacaugugag     1560

aaauaa                                                                1566


<210>  1408
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ELF2/m__Homo_sapiens__BAH13456

<400>  1408
auggccacca gccugcacga gggccccacc aaccagcucg accugcugau ccgcgccgug       60

gaggcguccg uccacagcuc caacgcccac ugcacggaca agaccaucga ggccgccgag      120

gcccuccugc acauggagag cccgaccugc cugcgggacu cccgcagccc cgaguucauc      180

cacgcggcca ugcggcccga cgugaucacc gagacggugg ucgagguguc caccgaggag      240

agcgagccca uggacaccuc cccgaucccc accagccccg acucccacga gcccaugaag      300

aagaagaagg uggggcgcaa gccgaagacg cagcagagcc ccaucuccaa cggcagcccc      360

gagcucggga ucaagaagaa gccccgggag ggcaagggga acaccaccua ccugugggag      420

uuccugcucg accugcugca ggacaagaac acgugcccgc gcuacaucaa guggacgcag      480

cgggagaagg gcaucuucaa gcucgucgac uccaaggccg ugagcaagcu guggggcaag      540

cacaagaaca agcccgacau gaacuacgag accauggggc gcgcccugcg guacuacuac      600

cagcgcggca uccucgcgaa gguggagggg cagcggcugg ucuaccaguu caaggacaug      660

cccaagaaca ucguggugau cgacgacgac aaguccgaga ccugcaacga ggaccuggcc      720

ggcaccacgg acgagaaguc ccucgagcgc gucagccuga gcgccgagag ccugcucaag      780

gccgccucca gcgugcgguc cgggaagaac agcuccccca ucaacugcag ccgcgcggag      840

aagggcgugg cccgggucgu gaacaucacc uccccgggcc acgacgccag cucccgcagc      900

cccaccacca cggccuccgu gagcgccacc gcggcgcccc ggaccguccg cguggccaug      960

cagguccccg uggugaugac cucccugggg cagaagauca gcacgguggc cguccagucc     1020

gugaacgccg gcgccccgcu gaucaccagc accuccccca ccacggccac cagccccaag     1080

gucgugaucc agaccauccc caccgugaug ccggccucca cggagaacgg ggacaagauc     1140

accaugcagc ccgccaagau caucaccauc cccgccaccc agcucgcgca gugccagcug     1200

cagaccaaga gcaaccugac cggcagcggc uccaucaaca ucgucgggac gccccucgcc     1260

gugcgggccc ugaccccggu gagcaucgcc cacggcaccc ccgucaugcg ccuguccaug     1320

cccacccagc aggcgagcgg gcagaccccg ccccggguga ucuccgccgu gaucaagggc     1380

cccgagguca agagcgaggc cguggccaag aagcaggagc acgacgugaa gacccuccag     1440

cuggucgagg agaagcccgc cgacgggaac aagaccguga cgcacguggu cguggugucc     1500

gcgccgagcg ccaucgcccu gcccgucacc augaagaccg agggccucgu gaccugcgag     1560

aaguga                                                                1566


<210>  1409
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ELF2/m__Homo_sapiens__BAH13456

<400>  1409
auggccaccu cccuccacga gggccccacc aaccagcucg accuccucau ccgcgccguc       60

gaggccuccg uccacuccuc caacgcccac ugcaccgaca agaccaucga ggccgccgag      120

gcccuccucc acauggaguc ccccaccugc cuccgcgacu cccgcucccc cgaguucauc      180

cacgccgcca ugcgccccga cgucaucacc gagaccgucg ucgaggucuc caccgaggag      240

uccgagccca uggacaccuc ccccaucccc accucccccg acucccacga gcccaugaag      300

aagaagaagg ucggccgcaa gcccaagacc cagcaguccc ccaucuccaa cggcuccccc      360

gagcucggca ucaagaagaa gccccgcgag ggcaagggca acaccaccua ccucugggag      420

uuccuccucg accuccucca ggacaagaac accugccccc gcuacaucaa guggacccag      480

cgcgagaagg gcaucuucaa gcucgucgac uccaaggccg ucuccaagcu cuggggcaag      540

cacaagaaca agcccgacau gaacuacgag accaugggcc gcgcccuccg cuacuacuac      600

cagcgcggca uccucgccaa ggucgagggc cagcgccucg ucuaccaguu caaggacaug      660

cccaagaaca ucgucgucau cgacgacgac aaguccgaga ccugcaacga ggaccucgcc      720

ggcaccaccg acgagaaguc ccucgagcgc gucucccucu ccgccgaguc ccuccucaag      780

gccgccuccu ccguccgcuc cggcaagaac uccuccccca ucaacugcuc ccgcgccgag      840

aagggcgucg cccgcgucgu caacaucacc ucccccggcc acgacgccuc cucccgcucc      900

cccaccacca ccgccuccgu cuccgccacc gccgcccccc gcaccguccg cgucgccaug      960

cagguccccg ucgucaugac cucccucggc cagaagaucu ccaccgucgc cguccagucc     1020

gucaacgccg gcgccccccu caucaccucc accuccccca ccaccgccac cucccccaag     1080

gucgucaucc agaccauccc caccgucaug cccgccucca ccgagaacgg cgacaagauc     1140

accaugcagc ccgccaagau caucaccauc cccgccaccc agcucgccca gugccagcuc     1200

cagaccaagu ccaaccucac cggcuccggc uccaucaaca ucgucggcac cccccucgcc     1260

guccgcgccc ucacccccgu cuccaucgcc cacggcaccc ccgucaugcg ccucuccaug     1320

cccacccagc aggccuccgg ccagaccccc ccccgcguca ucuccgccgu caucaagggc     1380

cccgagguca aguccgaggc cgucgccaag aagcaggagc acgacgucaa gacccuccag     1440

cucgucgagg agaagcccgc cgacggcaac aagaccguca cccacgucgu cgucgucucc     1500

gcccccuccg ccaucgcccu ccccgucacc augaagaccg agggccucgu caccugcgag     1560

aaguga                                                                1566


<210>  1410
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ELF2/m__Homo_sapiens__BAH13456

<400>  1410
auggccacca gccugcacga gggccccaca aaccagcucg accuucugau cagagcugug       60

gaagcauccg uccauucuuc aaaugcccac ugcacugaua agacgauuga ggcggcugaa      120

gccuuguuac auauggagag uccuaccugu cugagggaca gccggucccc agaguucaua      180

cacgcagcca ugcgcccgga uguuaucaca gaaacugugg uagagguguc uaccgaagag      240

ucggaaccca uggacacauc accuauucca accagccccg auagucauga gccuaugaaa      300

aagaaaaagg ucgggcgaaa accaaagacu caacaguccc ccaucucuaa cggaagcccu      360

gagcuaggua uuaagaaaaa gccacgugaa ggcaaaggga auacaaccua ccucugggag      420

uuucugcuug accuguugca ggauaagaac acgugcccga gauauaucaa auggacucag      480

agggaaaagg gaauauucaa gcucguggac uccaaagcug uuucaaagcu guggggcaaa      540

cacaagaaua aacccgauau gaacuacgag accauggguc gggcacugcg cuauuacuau      600

caaagaggga uccucgccaa gguggaagga cagagguuag ucuaccaguu uaaagacaug      660

ccuaagaaua uugugguaau cgaugacgau aagagugaga cauguaacga ggaccuggcu      720

ggcacuaccg acgagaaaag ccuugaacgg guuucuuugu ccgccgaauc acugcuaaag      780

gcggcaagca gugugcgcuc uggcaaaaau uccagcccaa uuaacugcuc gcgagccgag      840

aagggggucg cuagaguggu gaauaucaca ucucccggac acgaugccuc cucaaggagu      900

ccuaccacga cugcaagcgu cuccgcuaca gccgcgccac ggaccguucg uguggccaug      960

cagguacccg uggucaugac uucucucggu cagaaaauaa gcacaguggc aguucaauca     1020

gugaacgcug gcgccccgcu gauuaccagu acguccccua ccacagcuac uagccccaag     1080

gucgugaucc agaccauucc aacaguaaug ccugccucua cugaaaaugg ggacaagauc     1140

accaugcagc ccgcaaaaau cauuacaaua ccagccaccc aacuugcuca gugucagcug     1200

caaacuaagu caaacuugac gggaaguggc agcaucaaua uuguugguac accccucgcg     1260

gugcgcgcac ugaccccugu cuccaucgcc caugggacuc cagugaugag auuaucuaug     1320

ccgacccagc aggcuucggg acagacaccc ccuaggguca uaagcgccgu gauuaaaggc     1380

ccagagguua aguccgaggc aguggccaaa aagcaagaac acgauguaaa gacccugcag     1440

cucgucgagg aaaaacccgc ugacggcaac aagacuguga cacauguugu ggucguguca     1500

gccccuagug caaucgcgcu uccaguaacg augaaaaccg aggggcuggu gacuugcgaa     1560

aaguga                                                                1566


<210>  1411
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ELF2/m__Homo_sapiens__BAH13456

<400>  1411
auggccacca gccugcacga gggccccacc aaccagcugg accugcugau cagagccgug       60

gaggccagcg ugcacagcag caacgcccac ugcaccgaca agaccaucga ggccgccgag      120

gcccugcugc acauggagag ccccaccugc cugagagaca gcagaagccc cgaguucauc      180

cacgccgcca ugagacccga cgugaucacc gagaccgugg uggaggugag caccgaggag      240

agcgagccca uggacaccag ccccaucccc accagccccg acagccacga gcccaugaag      300

aagaagaagg ugggcagaaa gcccaagacc cagcagagcc ccaucagcaa cggcagcccc      360

gagcugggca ucaagaagaa gcccagagag ggcaagggca acaccaccua ccugugggag      420

uuccugcugg accugcugca ggacaagaac accugcccca gauacaucaa guggacccag      480

agagagaagg gcaucuucaa gcugguggac agcaaggccg ugagcaagcu guggggcaag      540

cacaagaaca agcccgacau gaacuacgag accaugggca gagcccugag auacuacuac      600

cagagaggca uccuggccaa gguggagggc cagagacugg uguaccaguu caaggacaug      660

cccaagaaca ucguggugau cgacgacgac aagagcgaga ccugcaacga ggaccuggcc      720

ggcaccaccg acgagaagag ccuggagaga gugagccuga gcgccgagag ccugcugaag      780

gccgccagca gcgugagaag cggcaagaac agcagcccca ucaacugcag cagagccgag      840

aagggcgugg ccagaguggu gaacaucacc agccccggcc acgacgccag cagcagaagc      900

cccaccacca ccgccagcgu gagcgccacc gccgccccca gaaccgugag aguggccaug      960

caggugcccg uggugaugac cagccugggc cagaagauca gcaccguggc cgugcagagc     1020

gugaacgccg gcgccccccu gaucaccagc accagcccca ccaccgccac cagccccaag     1080

guggugaucc agaccauccc caccgugaug cccgccagca ccgagaacgg cgacaagauc     1140

accaugcagc ccgccaagau caucaccauc cccgccaccc agcuggccca gugccagcug     1200

cagaccaaga gcaaccugac cggcagcggc agcaucaaca ucgugggcac cccccuggcc     1260

gugagagccc ugacccccgu gagcaucgcc cacggcaccc ccgugaugag acugagcaug     1320

cccacccagc aggccagcgg ccagaccccc cccagaguga ucagcgccgu gaucaagggc     1380

cccgagguga agagcgaggc cguggccaag aagcaggagc acgacgugaa gacccugcag     1440

cugguggagg agaagcccgc cgacggcaac aagaccguga cccacguggu gguggugagc     1500

gcccccagcg ccaucgcccu gcccgugacc augaagaccg agggccuggu gaccugcgag     1560

aaguga                                                                1566


<210>  1412
<211>  1566
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ELF2/m__Homo_sapiens__BAH13456

<400>  1412
auggccacca gccugcacga gggccccaca aaccagcucg accugcuuau cagagcugug       60

gaagccuccg uccauucuag caaugcgcac ugcacggaua agaccauuga ggcugccgaa      120

gcccugcucc auauggaguc cccuacaugu cugcgggacu cucgcagccc ggaguucauc      180

cacgcugcca ugagacccga uguuauuacc gaaacagugg uggaggucuc caccgaagag      240

ucugaaccua uggacacaag ccccaucccu accucccccg auagccauga gccuaugaaa      300

aagaaaaagg uggggcggaa accgaagacg caacagucuc ccauuuccaa cggaagcccu      360

gagcuuggca ucaagaaaaa gccccgcgaa gggaaaggaa auaccacaua ccugugggag      420

uuucuccugg accugcucca ggauaagaau accugcccua gauauaucaa auggacacag      480

cgggaaaagg gcauuuucaa gcugguugac ucuaaagcug uguccaaacu uugggggaaa      540

cacaagaaca aacccgauau gaacuacgag accaugggac gcgcccugag auauuacuau      600

caacggggca uccucgcgaa ggucgaaggc cagcgccugg uguaccaguu uaaagacaug      660

ccgaagaaua uuguugugau cgaugacgau aagagcgaga cguguaacga ggaccuugcc      720

gggacaaccg acgaaaaauc ucuggagaga gucucccuca gcgcugaauc ccugcugaag      780

gccgcuucua gcgugcgguc cggaaagaau agcucuccua uuaacugcuc ccgcgccgag      840

aagggcgugg cgagagucgu uaauaucaca agccccgggc acgaugccuc uagccggucc      900

ccuaccacca cagcuucugu gagcgccacg gcugcucccc gcaccgugag agucgccaug      960

caagugcccg uugugaugac aucccucgga cagaaaauua gcaccgucgc cgugcagucu     1020

guuaacgcgg gcgccccucu gaucacaucc accagcccga cgacagcuac cucucccaag     1080

guggucaucc agaccauucc uacagugaug cccgccucca ccgaaaaugg ggacaagauc     1140

acaaugcagc cugccaaaau uaucacgauu cccgcuaccc aacuugccca gugucagcug     1200

caaacaaaga gcaaccucac cggauccggc ucuaucaaua ucgucggcac accgcuggcg     1260

gugcgggcuc uuaccccugu uagcauugcc caugggacgc ccgugaugag acuguccaug     1320

ccuacccagc aggccucugg acagacaccc ccucgcguca ucagcgcugu gauuaaaggc     1380

cccgagguua aguccgaggc cguggcuaaa aagcaagaac acgaugucaa gacccuccag     1440

cugguggagg aaaaaccggc cgacgggaac aagacaguga cccauguugu cguggugagc     1500

gcgccuucug ccaucgcucu gcccgucacg augaaaacag agggacucgu gaccugcgaa     1560

aaguga                                                                1566


<210>  1413
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EMMPRIN__Homo_sapiens__Q54A51

<400>  1413

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210>  1414
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EMMPRIN__Homo_sapiens__BAC67168

<400>  1414
auggcggcug cgcuguucgu gcugcuggga uucgcgcugc ugggcaccca cggagccucc       60

ggggcugccg gcacagucuu cacuaccgua gaagaccuug gcuccaagau acuccucacc      120

ugcuccuuga augacagcgc cacagagguc acagggcacc gcuggcugaa ggggggcgug      180

gugcugaagg aggacgcgcu gcccggccag aaaacggagu ucaaggugga cuccgacgac      240

caguggggag aguacuccug cgucuuccuc cccgagccca ugggcacggc caacauccag      300

cuccacgggc cucccagagu gaaggcugug aagucgucag aacacaucaa cgagggggag      360

acggccaugc uggucugcaa gucagagucc gugccaccug ucacugacug ggccugguac      420

aagaucacug acucugagga caaggcccuc augaacggcu ccgagagcag guucuucgug      480

aguuccucgc agggccgguc agagcuacac auugagaacc ugaacaugga ggccgacccc      540

ggccaguacc ggugcaacgg caccagcucc aagggcuccg accaggccau caucacgcuc      600

cgcgugcgca gccaccuggc cgcccucugg cccuuccugg gcaucguggc ugaggugcug      660

gugcugguca ccaucaucuu caucuacgag aagcgccgga agcccgagga cguccuggau      720

gaugacgacg ccggcucugc accccugaag agcagcgggc agcaccagaa ugacaaaggc      780

aagaacgucc gccagaggaa cucuuccuga                                       810


<210>  1415
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EMMPRIN__Homo_sapiens__BAC67168

<400>  1415
auggccgccg cccuguucgu gcuccugggc uucgcccugc ucgggaccca cggcgccagc       60

ggggccgccg gcaccgucuu cacgaccgug gaggaccugg gguccaagau ccugcugacc      120

ugcagccuca acgacuccgc gaccgaggug acgggccacc gcuggcugaa gggcgggguc      180

gugcucaagg aggacgcccu gcccggccag aagaccgagu ucaaggugga cagcgacgac      240

caguggggcg aguacuccug cgucuuccug ccggagccca uggggaccgc caacauccag      300

cuccacgggc cgccccgggu gaaggccguc aagagcuccg agcacaucaa cgagggcgag      360

accgcgaugc uggugugcaa gagcgagucc gugccgcccg ugacggacug ggccugguac      420

aagaucaccg acagcgagga caaggcccug augaacggcu ccgagagccg cuucuucguc      480

uccagcuccc aggggcggag cgagcuccac aucgagaacc ugaacaugga ggccgacccc      540

ggccaguacc gcugcaacgg gaccuccagc aagggcuccg accaggccau caucacccug      600

cgggugcgca gccaccucgc ggcccugugg cccuuccugg gcaucguggc cgagguccuc      660

gugcugguga cgaucaucuu caucuacgag aagcggcgca agcccgagga cguccuggac      720

gacgacgacg ccgggagcgc gccccucaag uccagcggcc agcaccagaa cgacaagggg      780

aagaacgugc ggcagcgcaa cuccagcuga                                       810


<210>  1416
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EMMPRIN__Homo_sapiens__BAC67168

<400>  1416
auggccgccg cccucuucgu ccuccucggc uucgcccucc ucggcaccca cggcgccucc       60

ggcgccgccg gcaccgucuu caccaccguc gaggaccucg gcuccaagau ccuccucacc      120

ugcucccuca acgacuccgc caccgagguc accggccacc gcuggcucaa gggcggcguc      180

guccucaagg aggacgcccu ccccggccag aagaccgagu ucaaggucga cuccgacgac      240

caguggggcg aguacuccug cgucuuccuc cccgagccca ugggcaccgc caacauccag      300

cuccacggcc ccccccgcgu caaggccguc aaguccuccg agcacaucaa cgagggcgag      360

accgccaugc ucgucugcaa guccgagucc gucccccccg ucaccgacug ggccugguac      420

aagaucaccg acuccgagga caaggcccuc augaacggcu ccgagucccg cuucuucguc      480

uccuccuccc agggccgcuc cgagcuccac aucgagaacc ucaacaugga ggccgacccc      540

ggccaguacc gcugcaacgg caccuccucc aagggcuccg accaggccau caucacccuc      600

cgcguccgcu cccaccucgc cgcccucugg cccuuccucg gcaucgucgc cgagguccuc      660

guccucguca ccaucaucuu caucuacgag aagcgccgca agcccgagga cguccucgac      720

gacgacgacg ccggcuccgc cccccucaag uccuccggcc agcaccagaa cgacaagggc      780

aagaacgucc gccagcgcaa cuccuccuga                                       810


<210>  1417
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EMMPRIN__Homo_sapiens__BAC67168

<400>  1417
auggccgcug cacuguucgu gcuccuugga uuugcccugu uggggaccca cggagcgagc       60

ggugcugccg gcacagucuu cacuacgguu gaggacuuag gguccaagau ccugcuaacc      120

ugcucucuca acgauucagc aacagaagug acuggacaua gauggcugaa aggcggugua      180

gugcuuaagg aggacgcccu gcccgggcag aaaaccgaau uuaaggucga uagugacgau      240

caauggggag aguacagcug uguguucuug ccugaaccaa ugggcacagc uaauauucag      300

cuccacggcc cgcccagggu uaaagcagug aaguccucug agcauauaaa cgagggggaa      360

accgccaugc uggucugcaa gucggaguca gugccuccag uaacugacug ggcuugguau      420

aaaaucacag auagcgaaga caaggcccug augaauggaa gugagucccg guuuuucguu      480

ucuagcuccc agggucgcuc agagcuccac auugaaaacu uaaauaugga ggcggauccc      540

ggccaguacc gauguaacgg gaccaguagc aaaggaucug accaagcaau cauuacgcug      600

cgugugagau cccaucuugc cgcuuugugg ccuuuucugg gcaucgucgc cgaagugcua      660

gugcucguca cuauaaucuu cauuuaugag aagaggcgga aaccagaaga uguucuggac      720

gaugacgacg cagguucagc uccccuuaag agcagugggc agcaccagaa ugauaagggc      780

aaaaacgugc gccagagaaa uucuuccuga                                       810


<210>  1418
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EMMPRIN__Homo_sapiens__BAC67168

<400>  1418
auggccgccg cccuguucgu gcugcugggc uucgcccugc ugggcaccca cggcgccagc       60

ggcgccgccg gcaccguguu caccaccgug gaggaccugg gcagcaagau ccugcugacc      120

ugcagccuga acgacagcgc caccgaggug accggccaca gauggcugaa gggcggcgug      180

gugcugaagg aggacgcccu gcccggccag aagaccgagu ucaaggugga cagcgacgac      240

caguggggcg aguacagcug cguguuccug cccgagccca ugggcaccgc caacauccag      300

cugcacggcc cccccagagu gaaggccgug aagagcagcg agcacaucaa cgagggcgag      360

accgccaugc uggugugcaa gagcgagagc gugccccccg ugaccgacug ggccugguac      420

aagaucaccg acagcgagga caaggcccug augaacggca gcgagagcag auucuucgug      480

agcagcagcc agggcagaag cgagcugcac aucgagaacc ugaacaugga ggccgacccc      540

ggccaguaca gaugcaacgg caccagcagc aagggcagcg accaggccau caucacccug      600

agagugagaa gccaccuggc cgcccugugg cccuuccugg gcaucguggc cgaggugcug      660

gugcugguga ccaucaucuu caucuacgag aagagaagaa agcccgagga cgugcuggac      720

gacgacgacg ccggcagcgc cccccugaag agcagcggcc agcaccagaa cgacaagggc      780

aagaacguga gacagagaaa cagcagcuga                                       810


<210>  1419
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EMMPRIN__Homo_sapiens__BAC67168

<400>  1419
auggccgccg cccuguucgu gcuccuggga uuugcgcuuc uggggaccca cggagcuagc       60

ggcgccgccg ggacagucuu cacgaccguu gaggaccucg gauccaagau ccugcuuaca      120

ugcucucuga acgauagcgc uaccgaagug acaggccauc gguggcucaa agggggagug      180

guccugaagg aggacgcccu gcccggccag aaaaccgaau uuaaggugga uuccgacgau      240

caauggggcg aguacucuug uguuuuccuc ccugaaccga uggggacagc uaauauucag      300

cugcacggac ccccucgggu gaaagccguc aagagcuccg agcauaucaa cgagggcgaa      360

accgcgaugc uugugugcaa gucugagagc guucccccug ugacggacug ggccugguau      420

aaaauuaccg auuccgaaga caaggcucug augaauggga gcgagucucg cuuuuucguc      480

uccagcucuc agggaagauc cgagcuccac aucgaaaacc ugaauaugga ggccgauccc      540

ggccaguacc gguguaacgg gacaagcucu aaaggauccg accaagcuau uaucacccuu      600

cgcgugagaa gccaucuggc cgcgcucugg ccuuuucugg gcaucguggc cgaaguccug      660

guucucguga caauuaucuu cauuuaugag aagcggcgca aaccggaaga ugugcuggac      720

gaugacgacg cuggcuccgc uccccuuaag ucuagcgggc agcaccagaa ugauaagggc      780

aaaaacguca gacagagaaa uuccagcuga                                       810


<210>  1420
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EpCam__Homo_sapiens__P16422

<400>  1420

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  1421
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EpCam__Homo_sapiens__AAA35723

<400>  1421
auggcgcccc cgcagguccu cgcguucggg cuucugcuug ccgcggcgac ggcgacuuuu       60

gccgcagcuc aggaagaaug ugucugugaa aacuacaagc uggccguaaa cugcuuugug      120

aauaauaauc gucaaugcca guguacuuca guuggugcac aaaauacugu cauuugcuca      180

aagcuggcug ccaaauguuu ggugaugaag gcagaaauga auggcucaaa acuugggaga      240

agagcaaaac cugaaggggc ccuccagaac aaugaugggc uuuaugaucc ugacugcgau      300

gagagcgggc ucuuuaaggc caagcagugc aacggcaccu ccaugugcug gugugugaac      360

acugcugggg ucagaagaac agacaaggac acugaaauaa ccugcucuga gcgagugaga      420

accuacugga ucaucauuga acuaaaacac aaagcaagag aaaaaccuua ugauaguaaa      480

aguuugcgga cugcacuuca gaaggagauc acaacgcguu aucaacugga uccaaaauuu      540

aucacgagua uuuuguauga gaauaauguu aucacuauug aucugguuca aaauucuucu      600

caaaaaacuc agaaugaugu ggacauagcu gauguggcuu auuauuuuga aaaagauguu      660

aaaggugaau ccuuguuuca uucuaagaaa auggaccuga caguaaaugg ggaacaacug      720

gaucuggauc cuggucaaac uuuaauuuau uauguugaug aaaaagcacc ugaauucuca      780

augcaggguc uaaaagcugg uguuauugcu guuauugugg uuguggugau agcaguuguu      840

gcuggaauug uugugcuggu uauuuccaga aagaagagaa uggcaaagua ugagaaggcu      900

gagauaaagg agauggguga gaugcauagg gaacucaaug cauaa                      945


<210>  1422
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EpCam__Homo_sapiens__AAA35723

<400>  1422
auggccccgc cccaggugcu ggccuucggc cuccugcugg cggccgccac cgccaccuuc       60

gccgcggccc aggaggagug cgucugcgag aacuacaagc ucgccgugaa cugcuucgug      120

aacaacaacc gccagugcca gugcacgagc gucggggccc agaacaccgu gaucugcucc      180

aagcuggcgg ccaagugccu ggugaugaag gccgagauga acggcagcaa gcucgggcgg      240

cgcgccaagc ccgagggcgc ccugcagaac aacgacgggc uguacgaccc cgacugcgac      300

gaguccggcc ucuucaaggc gaagcagugc aacggcacca gcaugugcug gugcgucaac      360

accgccgggg ugcggcgcac ggacaaggac accgagauca cgugcuccga gcgggugcgc      420

accuacugga ucaucaucga gcugaagcac aaggcccggg agaagcccua cgacagcaag      480

ucccugcgca ccgcccucca gaaggagauc accacccggu accagcugga cccgaaguuc      540

aucaccagca uccuguacga gaacaacguc aucacgaucg accucgugca gaacuccagc      600

cagaagaccc agaacgacgu ggacaucgcc gacgucgcgu acuacuucga gaaggacgug      660

aagggcgagu cccuguucca cagcaagaag auggaccuga ccgugaacgg ggagcagcuc      720

gaccuggacc ccggccagac ccugaucuac uacgucgacg agaaggcccc cgaguucucc      780

augcaggggc ucaaggccgg cgugaucgcc gugaucgucg ugguggucau cgccguggug      840

gcgggcaucg ucgugcuggu caucagccgc aagaagcgga uggccaagua cgagaaggcc      900

gagaucaagg agauggggga gaugcaccgc gagcugaacg ccuga                      945


<210>  1423
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EpCam__Homo_sapiens__AAA35723

<400>  1423
auggcccccc cccagguccu cgccuucggc cuccuccucg ccgccgccac cgccaccuuc       60

gccgccgccc aggaggagug cgucugcgag aacuacaagc ucgccgucaa cugcuucguc      120

aacaacaacc gccagugcca gugcaccucc gucggcgccc agaacaccgu caucugcucc      180

aagcucgccg ccaagugccu cgucaugaag gccgagauga acggcuccaa gcucggccgc      240

cgcgccaagc ccgagggcgc ccuccagaac aacgacggcc ucuacgaccc cgacugcgac      300

gaguccggcc ucuucaaggc caagcagugc aacggcaccu ccaugugcug gugcgucaac      360

accgccggcg uccgccgcac cgacaaggac accgagauca ccugcuccga gcgcguccgc      420

accuacugga ucaucaucga gcucaagcac aaggcccgcg agaagcccua cgacuccaag      480

ucccuccgca ccgcccucca gaaggagauc accacccgcu accagcucga ccccaaguuc      540

aucaccucca uccucuacga gaacaacguc aucaccaucg accucgucca gaacuccucc      600

cagaagaccc agaacgacgu cgacaucgcc gacgucgccu acuacuucga gaaggacguc      660

aagggcgagu cccucuucca cuccaagaag auggaccuca ccgucaacgg cgagcagcuc      720

gaccucgacc ccggccagac ccucaucuac uacgucgacg agaaggcccc cgaguucucc      780

augcagggcc ucaaggccgg cgucaucgcc gucaucgucg ucgucgucau cgccgucguc      840

gccggcaucg ucguccucgu caucucccgc aagaagcgca uggccaagua cgagaaggcc      900

gagaucaagg agaugggcga gaugcaccgc gagcucaacg ccuga                      945


<210>  1424
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EpCam__Homo_sapiens__AAA35723

<400>  1424
auggcucccc cucaggugcu ggccuucggc cuccuucugg cagccgcgac cgcuacauuu       60

gccgcagccc aagaggaaug cgucugugag aacuacaagu uggcuguuaa uugcuucgug      120

aacaauaaca gacaguguca gugcacuagc guaggggcac agaauacggu gaucuguucc      180

aaauuagccg cuaagugccu ggucaugaaa gccgaaauga acggaucuaa gcuagguagg      240

cgggcgaaac cagagggcgc acuccaaaau aacgacgggc uguaugaucc ggacugugau      300

gaaucaggac uuuuuaaggc caagcagugc aauggcacca guauguguug gugcgugaac      360

acagcuggug uucgccgaac ugacaaagau accgagauua cauguagcga gcgugugaga      420

accuacugga uaaucauuga acugaagcac aaagccaggg agaagcccua ugacuccaaa      480

ucuuugcgga cugcacucca gaaggaaauc acaacccgcu accagcugga uccuaaguuc      540

auuacgucga uccuguauga gaauaacguc auaacuaucg accucgugca aaauucaagc      600

cagaaaaccc agaacgaugu agacauugcu gauguugccu acuauuuuga gaaggacgug      660

aaaggggaaa guuuauucca uuccaagaaa auggaucuga cagucaaugg agagcagcuu      720

gacuuggacc caggccaaac ucugaucuac uacguggaug aaaaggcgcc cgaguuuucu      780

augcagggcc uaaaagccgg ggugauugca gucaucguug ugguagugau agcugucgug      840

gccggaauug uugugcucgu caucagcaga aagaagagga uggcuaaaua ugaaaaggcc      900

gagauuaaag agauggguga aaugcaccgg gagcugaacg cauga                      945


<210>  1425
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EpCam__Homo_sapiens__AAA35723

<400>  1425
auggcccccc cccaggugcu ggccuucggc cugcugcugg ccgccgccac cgccaccuuc       60

gccgccgccc aggaggagug cgugugcgag aacuacaagc uggccgugaa cugcuucgug      120

aacaacaaca gacagugcca gugcaccagc gugggcgccc agaacaccgu gaucugcagc      180

aagcuggccg ccaagugccu ggugaugaag gccgagauga acggcagcaa gcugggcaga      240

agagccaagc ccgagggcgc ccugcagaac aacgacggcc uguacgaccc cgacugcgac      300

gagagcggcc uguucaaggc caagcagugc aacggcacca gcaugugcug gugcgugaac      360

accgccggcg ugagaagaac cgacaaggac accgagauca ccugcagcga gagagugaga      420

accuacugga ucaucaucga gcugaagcac aaggccagag agaagcccua cgacagcaag      480

agccugagaa ccgcccugca gaaggagauc accaccagau accagcugga ccccaaguuc      540

aucaccagca uccuguacga gaacaacgug aucaccaucg accuggugca gaacagcagc      600

cagaagaccc agaacgacgu ggacaucgcc gacguggccu acuacuucga gaaggacgug      660

aagggcgaga gccuguucca cagcaagaag auggaccuga ccgugaacgg cgagcagcug      720

gaccuggacc ccggccagac ccugaucuac uacguggacg agaaggcccc cgaguucagc      780

augcagggcc ugaaggccgg cgugaucgcc gugaucgugg ugguggugau cgccguggug      840

gccggcaucg uggugcuggu gaucagcaga aagaagagaa uggccaagua cgagaaggcc      900

gagaucaagg agaugggcga gaugcacaga gagcugaacg ccuga                      945


<210>  1426
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EpCam__Homo_sapiens__AAA35723

<400>  1426
auggcucccc cucaggugcu ggccuucggc cuccugcuug ccgcggcuac cgccacauuu       60

gccgcugccc aagaggaaug cgucugugag aacuacaagc uggcuguuaa uugcuucgug      120

aacaauaaca gacaguguca gugcacgagc gugggggccc agaauaccgu caucuguucc      180

aaacucgcgg ccaagugccu ggugaugaaa gcugaaauga acggaucuaa acuuggccgg      240

cgcgccaagc cggagggggc ucugcaaaau aacgacggac ucuaugaucc cgacugugau      300

gaaagcggcc uguuuaaggc caagcagugc aaugggacau ccauguguug gugcguuaac      360

accgcgggag ugagacggac agacaaagau accgagauua cauguucuga gcgcgucaga      420

accuacugga ucauuaucga acugaagcac aaagcccggg agaagccuua ugacagcaaa      480

ucccuccgca cggcucugca gaaggaaauu accacaagau accagcuuga ucccaaguuc      540

aucaccucua uccuguauga gaauaacgug auuacaaucg accucguuca aaauagcucc      600

cagaaaaccc agaacgaugu ggacauugcc gaugucgcuu acuauuuuga gaaggacgug      660

aaaggcgaaa gccuguucca uucuaagaaa auggaucuua cggugaaugg cgagcagcug      720

gaccucgacc cugggcaaac acugaucuac uacgucgaug aaaaggcccc cgaguuuucc      780

augcagggac ugaaagccgg cguuauugcu gugaucgugg ucgugguuau ugcggugguc      840

gccgggaucg ugguucucgu gaucagccgg aagaagcgca uggcuaaaua ugaaaaggcc      900

gagauuaaag agaugggaga aaugcacaga gagcugaacg ccuga                      945


<210>  1427
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EphA2__Homo_sapiens__P29317

<400>  1427

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     






<210>  1428
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EphA2__Homo_sapiens__CCDS169.1

<400>  1428
auggagcucc aggcagcccg cgccugcuuc gcccugcugu ggggcugugc gcuggccgcg       60

gccgcggcgg cgcagggcaa ggaaguggua cugcuggacu uugcugcagc uggaggggag      120

cucggcuggc ucacacaccc guauggcaaa gggugggacc ugaugcagaa caucaugaau      180

gacaugccga ucuacaugua cuccgugugc aacgugaugu cuggcgacca ggacaacugg      240

cuccgcacca acugggugua ccgaggagag gcugagcgua ucuucauuga gcucaaguuu      300

acuguacgug acugcaacag cuucccuggu ggcgccagcu ccugcaagga gacuuucaac      360

cucuacuaug ccgagucgga ccuggacuac ggcaccaacu uccagaagcg ccuguucacc      420

aagauugaca ccauugcgcc cgaugagauc accgucagca gcgacuucga ggcacgccac      480

gugaagcuga acguggagga gcgcuccgug gggccgcuca cccgcaaagg cuucuaccug      540

gccuuccagg auaucggugc cuguguggcg cugcucuccg uccgugucua cuacaagaag      600

ugccccgagc ugcugcaggg ccuggcccac uucccugaga ccaucgccgg cucugaugca      660

ccuucccugg ccacuguggc cggcaccugu guggaccaug ccguggugcc accggggggu      720

gaagagcccc guaugcacug ugcaguggau ggcgaguggc uggugcccau ugggcagugc      780

cugugccagg caggcuacga gaagguggag gaugccugcc aggccugcuc gccuggauuu      840

uuuaaguuug aggcaucuga gagccccugc uuggagugcc cugagcacac gcugccaucc      900

ccugagggug ccaccuccug cgagugugag gaaggcuucu uccgggcacc ucaggaccca      960

gcgucgaugc cuugcacacg accccccucc gccccacacu accucacagc cgugggcaug     1020

ggugccaagg uggagcugcg cuggacgccc ccucaggaca gcgggggccg cgaggacauu     1080

gucuacagcg ucaccugcga acagugcugg cccgagucug gggaaugcgg gccgugugag     1140

gccagugugc gcuacucgga gccuccucac ggacugaccc gcaccagugu gacagugagc     1200

gaccuggagc cccacaugaa cuacaccuuc accguggagg cccgcaaugg cgucucaggc     1260

cugguaacca gccgcagcuu ccguacugcc agugucagca ucaaccagac agagcccccc     1320

aaggugaggc uggagggccg cagcaccacc ucgcuuagcg ucuccuggag cauccccccg     1380

ccgcagcaga gccgagugug gaaguacgag gucacuuacc gcaagaaggg agacuccaac     1440

agcuacaaug ugcgccgcac cgaggguuuc uccgugaccc uggacgaccu ggccccagac     1500

accaccuacc ugguccaggu gcaggcacug acgcaggagg gccagggggc cggcagcaag     1560

gugcacgaau uccagacgcu guccccggag ggaucuggca acuuggcggu gauuggcggc     1620

guggcugucg gugugguccu gcuucuggug cuggcaggag uuggcuucuu uauccaccgc     1680

aggaggaaga accagcgugc ccgccagucc ccggaggacg uuuacuucuc caagucagaa     1740

caacugaagc cccugaagac auacguggac ccccacacau augaggaccc caaccaggcu     1800

guguugaagu ucacuaccga gauccaucca uccuguguca cucggcagaa ggugaucgga     1860

gcaggagagu uuggggaggu guacaagggc augcugaaga cauccucggg gaagaaggag     1920

gugccggugg ccaucaagac gcugaaagcc ggcuacacag agaagcagcg aguggacuuc     1980

cucggcgagg ccggcaucau gggccaguuc agccaccaca acaucauccg ccuagagggc     2040

gucaucucca aauacaagcc caugaugauc aucacugagu acauggagaa uggggcccug     2100

gacaaguucc uucgggagaa ggauggcgag uucagcgugc ugcagcuggu gggcaugcug     2160

cggggcaucg cagcuggcau gaaguaccug gccaacauga acuaugugca ccgugaccug     2220

gcugcccgca acauccucgu caacagcaac cuggucugca aggugucuga cuuuggccug     2280

ucccgcgugc uggaggacga ccccgaggcc accuacacca ccaguggcgg caagaucccc     2340

auccgcugga ccgccccgga ggccauuucc uaccggaagu ucaccucugc cagcgacgug     2400

uggagcuuug gcauugucau gugggaggug augaccuaug gcgagcggcc cuacugggag     2460

uuguccaacc acgaggugau gaaagccauc aaugauggcu uccggcuccc cacacccaug     2520

gacugccccu ccgccaucua ccagcucaug augcagugcu ggcagcagga gcgugcccgc     2580

cgccccaagu ucgcugacau cgucagcauc cuggacaagc ucauucgugc cccugacucc     2640

cucaagaccc uggcugacuu ugacccccgc gugucuaucc ggcuccccag cacgagcggc     2700

ucggaggggg ugcccuuccg cacggugucc gaguggcugg aguccaucaa gaugcagcag     2760

uauacggagc acuucauggc ggccggcuac acugccaucg agaagguggu gcagaugacc     2820

aacgacgaca ucaagaggau uggggugcgg cugcccggcc accagaagcg caucgccuac     2880

agccugcugg gacucaagga ccaggugaac acugugggga uccccaucug a              2931


<210>  1429
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EphA2__Homo_sapiens__CCDS169.1

<400>  1429
auggagcugc aggccgcccg cgcgugcuuc gcccuccugu ggggcugcgc ccuggccgcc       60

gcggccgccg cccaggggaa ggaggugguc cuccuggacu ucgcggccgc cggcggggag      120

cugggcuggc ucacccaccc cuacgggaag ggcugggacc ugaugcagaa caucaugaac      180

gacaugccga ucuacaugua cagcgugugc aacgugaugu ccggcgacca ggacaacugg      240

cugcggacca acugggucua ccgcggggag gccgagcgga ucuucaucga gcucaaguuc      300

acggugcgcg acugcaacag cuuccccggc ggggccucca gcugcaagga gaccuucaac      360

cuguacuacg cggaguccga ccuggacuac ggcaccaacu uccagaagcg ccucuucacc      420

aagaucgaca cgaucgcccc cgacgagauc accgugagcu ccgacuucga ggcccgccac      480

gucaagcuga acguggagga gcggagcgug gggccccuga cccgcaaggg cuucuaccuc      540

gccuuccagg acaucggcgc cugcgucgcg cugcuguccg ugcgggugua cuacaagaag      600

ugcccggagc uccugcaggg gcuggcccac uuccccgaga ccaucgccgg cagcgacgcc      660

cccucccucg ccacggucgc ggggaccugc guggaccacg ccguggugcc cccgggcggc      720

gaggagcccc gcaugcacug cgccguggac ggggaguggc uggugcccau cggccagugc      780

cugugccagg ccggguacga gaaggucgag gacgccugcc aggcgugcag ccccggcuuc      840

uucaaguucg aggccuccga gagcccgugc cucgagugcc ccgagcacac ccugcccucc      900

cccgaggggg ccaccagcug cgagugcgag gagggcuucu uccgggcccc gcaggacccc      960

gcguccaugc ccugcacgcg gcccccgagc gcgccccacu accugaccgc cgugggcaug     1020

ggggccaagg uggagcuccg guggaccccg ccccaggacu ccggcgggcg cgaggacauc     1080

gucuacagcg ugaccugcga gcagugcugg cccgagagcg gcgagugcgg gcccugcgag     1140

gccuccgugc gguacagcga gccgccccac ggccugacgc gcaccuccgu caccgugagc     1200

gaccuggagc cccacaugaa cuacaccuuc acggucgagg cccggaacgg cguguccggg     1260

cucgugacca gccgcuccuu ccggaccgcc agcgucucca ucaaccagac cgagccgccc     1320

aaggugcgcc uggagggccg gagcacgacc ucccugagcg uguccuggag caucccgccg     1380

ccccagcagu cccgcgucug gaaguacgag gugaccuacc gcaagaaggg ggacagcaac     1440

uccuacaacg ugcggcgcac cgagggcuuc agcgucacgc ucgacgaccu ggcccccgac     1500

accaccuacc ugguccaggu gcaggcccuc acccaggagg ggcagggcgc cggcuccaag     1560

guccacgagu uccagacgcu gagccccgag gggagcggca accuggcggu gaucgggggc     1620

guggccgucg gcguggugcu ccugcugguc cucgccgggg ugggcuucuu cauccaccgg     1680

cgccggaaga accagcgcgc ccggcagucc cccgaggacg uguacuucag caaguccgag     1740

cagcugaagc cccugaagac cuacgucgac ccccacaccu acgaggaccc caaccaggcc     1800

gugcucaagu ucaccacgga gauccacccc agcugcguga cccgccagaa ggucaucggg     1860

gcgggcgagu ucggggaggu guacaagggc augcugaaga ccuccagcgg caagaaggag     1920

gugcccgucg ccaucaagac ccugaaggcc ggguacaccg agaagcagcg gguggacuuc     1980

cucggcgagg ccgggaucau gggccaguuc ucccaccaca acaucauccg ccuggagggg     2040

gugaucagca aguacaagcc caugaugauc aucacggagu acauggagaa cggcgcgcug     2100

gacaaguucc ugcgggagaa ggacggcgag uucuccgucc uccagcuggu ggggaugcug     2160

cgcggcaucg ccgccgggau gaaguaccuc gccaacauga acuacgugca ccgggaccug     2220

gccgcgcgca acauccuggu caacagcaac cucgugugca agguguccga cuucggccug     2280

agccgggucc uggaggacga cccggaggcc accuacacca ccuccggggg caagaucccc     2340

auccgcugga cggcccccga ggccaucagc uaccggaagu ucaccuccgc cagcgacgug     2400

ugguccuucg gcaucgugau gugggagguc augaccuacg gggagcgccc cuacugggag     2460

cucagcaacc acgaggugau gaaggcgauc aacgacggcu uccggcugcc gacccccaug     2520

gacugcccca gcgccaucua ccagcugaug augcagugcu ggcagcagga gcgcgcccgc     2580

cggcccaagu ucgccgacau cguguccauc cucgacaagc ugauccgcgc cccggacagc     2640

cugaagacgc ucgcggacuu cgacccccgg gucuccaucc gccugcccag caccuccggg     2700

agcgagggcg ugcccuuccg gaccgugucc gaguggcugg agagcaucaa gaugcagcag     2760

uacaccgagc acuucauggc cgccggguac acggccaucg agaaggucgu gcagaugacc     2820

aacgacgaca ucaagcgcau cggcgugcgg cucccgggcc accagaagcg caucgcguac     2880

ucccugcugg ggcucaagga ccaggucaac accgugggca uccccaucug a              2931


<210>  1430
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EphA2__Homo_sapiens__CCDS169.1

<400>  1430
auggagcucc aggccgcccg cgccugcuuc gcccuccucu ggggcugcgc ccucgccgcc       60

gccgccgccg cccagggcaa ggaggucguc cuccucgacu ucgccgccgc cggcggcgag      120

cucggcuggc ucacccaccc cuacggcaag ggcugggacc ucaugcagaa caucaugaac      180

gacaugccca ucuacaugua cuccgucugc aacgucaugu ccggcgacca ggacaacugg      240

cuccgcacca acugggucua ccgcggcgag gccgagcgca ucuucaucga gcucaaguuc      300

accguccgcg acugcaacuc cuuccccggc ggcgccuccu ccugcaagga gaccuucaac      360

cucuacuacg ccgaguccga ccucgacuac ggcaccaacu uccagaagcg ccucuucacc      420

aagaucgaca ccaucgcccc cgacgagauc accgucuccu ccgacuucga ggcccgccac      480

gucaagcuca acgucgagga gcgcuccguc ggcccccuca cccgcaaggg cuucuaccuc      540

gccuuccagg acaucggcgc cugcgucgcc cuccucuccg uccgcgucua cuacaagaag      600

ugccccgagc uccuccaggg ccucgcccac uuccccgaga ccaucgccgg cuccgacgcc      660

cccucccucg ccaccgucgc cggcaccugc gucgaccacg ccgucguccc ccccggcggc      720

gaggagcccc gcaugcacug cgccgucgac ggcgaguggc ucguccccau cggccagugc      780

cucugccagg ccggcuacga gaaggucgag gacgccugcc aggccugcuc ccccggcuuc      840

uucaaguucg aggccuccga gucccccugc cucgagugcc ccgagcacac ccuccccucc      900

cccgagggcg ccaccuccug cgagugcgag gagggcuucu uccgcgcccc ccaggacccc      960

gccuccaugc ccugcacccg cccccccucc gccccccacu accucaccgc cgucggcaug     1020

ggcgccaagg ucgagcuccg cuggaccccc ccccaggacu ccggcggccg cgaggacauc     1080

gucuacuccg ucaccugcga gcagugcugg cccgaguccg gcgagugcgg ccccugcgag     1140

gccuccgucc gcuacuccga gcccccccac ggccucaccc gcaccuccgu caccgucucc     1200

gaccucgagc cccacaugaa cuacaccuuc accgucgagg cccgcaacgg cgucuccggc     1260

cucgucaccu cccgcuccuu ccgcaccgcc uccgucucca ucaaccagac cgagcccccc     1320

aagguccgcc ucgagggccg cuccaccacc ucccucuccg ucuccugguc cauccccccc     1380

ccccagcagu cccgcgucug gaaguacgag gucaccuacc gcaagaaggg cgacuccaac     1440

uccuacaacg uccgccgcac cgagggcuuc uccgucaccc ucgacgaccu cgcccccgac     1500

accaccuacc ucguccaggu ccaggcccuc acccaggagg gccagggcgc cggcuccaag     1560

guccacgagu uccagacccu cucccccgag ggcuccggca accucgccgu caucggcggc     1620

gucgccgucg gcgucguccu ccuccucguc cucgccggcg ucggcuucuu cauccaccgc     1680

cgccgcaaga accagcgcgc ccgccagucc cccgaggacg ucuacuucuc caaguccgag     1740

cagcucaagc cccucaagac cuacgucgac ccccacaccu acgaggaccc caaccaggcc     1800

guccucaagu ucaccaccga gauccacccc uccugcguca cccgccagaa ggucaucggc     1860

gccggcgagu ucggcgaggu cuacaagggc augcucaaga ccuccuccgg caagaaggag     1920

guccccgucg ccaucaagac ccucaaggcc ggcuacaccg agaagcagcg cgucgacuuc     1980

cucggcgagg ccggcaucau gggccaguuc ucccaccaca acaucauccg ccucgagggc     2040

gucaucucca aguacaagcc caugaugauc aucaccgagu acauggagaa cggcgcccuc     2100

gacaaguucc uccgcgagaa ggacggcgag uucuccgucc uccagcucgu cggcaugcuc     2160

cgcggcaucg ccgccggcau gaaguaccuc gccaacauga acuacgucca ccgcgaccuc     2220

gccgcccgca acauccucgu caacuccaac cucgucugca aggucuccga cuucggccuc     2280

ucccgcgucc ucgaggacga ccccgaggcc accuacacca ccuccggcgg caagaucccc     2340

auccgcugga ccgcccccga ggccaucucc uaccgcaagu ucaccuccgc cuccgacguc     2400

ugguccuucg gcaucgucau gugggagguc augaccuacg gcgagcgccc cuacugggag     2460

cucuccaacc acgaggucau gaaggccauc aacgacggcu uccgccuccc cacccccaug     2520

gacugccccu ccgccaucua ccagcucaug augcagugcu ggcagcagga gcgcgcccgc     2580

cgccccaagu ucgccgacau cgucuccauc cucgacaagc ucauccgcgc ccccgacucc     2640

cucaagaccc ucgccgacuu cgacccccgc gucuccaucc gccuccccuc caccuccggc     2700

uccgagggcg uccccuuccg caccgucucc gaguggcucg aguccaucaa gaugcagcag     2760

uacaccgagc acuucauggc cgccggcuac accgccaucg agaaggucgu ccagaugacc     2820

aacgacgaca ucaagcgcau cggcguccgc cuccccggcc accagaagcg caucgccuac     2880

ucccuccucg gccucaagga ccaggucaac accgucggca uccccaucug a              2931


<210>  1431
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EphA2__Homo_sapiens__CCDS169.1

<400>  1431
auggagcugc aggccgcuag agcaugcuuc gcccuccuuu ggggcugugc gcuggcugcc       60

gcagccgcug cacaagggaa ggaagugguc uuguuagacu uugccgcugc cggaggugag      120

cugggcuggc uaacccaccc cuacgggaaa ggaugggauc ucaugcagaa caucaugaau      180

gacaugccua uuuauaugua cagcguuugc aacgugaugu ccggcgauca ggacaauugg      240

cugaggacaa acuggguaua ucggggugaa gcggagcgca uauucaucga acuuaaguuu      300

acugugcgag auuguaauuc uuucccaggg ggagcaucaa guugcaaaga gacguuuaac      360

cuguacuaug ccgagagcga cuuggauuac ggcaccaauu uccagaagcg ucucuuuaca      420

aaaauugaca cuaucgcucc ggaugaaauu accgucuccu cugacuucga ggccagacau      480

gugaagcuga acguugaaga gaggucggug ggcccccuga cacggaaggg guuuuaucuc      540

gcauuccaag auaucggagc uugugucgcc uuacugucag ugcgcguaua cuacaaaaag      600

ugcccugagc uuuugcaggg ucuggcgcac uuuccagaaa ccauagccgg cagcgacgca      660

cccagucuag cuacuguugc cgggacaugu guggaucaug cugucgugcc uccaggaggc      720

gaggaaccca gaaugcacug cgccguggac ggugaguggc ucgucccuau cgggcagugu      780

cugugccagg caggauauga aaaaguugag gacgccuguc aagccugcuc cccaggcuuc      840

uuuaaguucg aggcgucuga aagcccgugc cuugaguguc ccgaacauac ccugccuucc      900

ccagagggcg caacgucaug cgaaugugag gagggguucu uuagggcucc ccaggauccu      960

gcuaguaugc caugcacucg gcccccgagc gccccucacu acuugaccgc agugggaaug     1020

ggugccaaag uagaacuccg cuggacaccc ccacaggacu cuggcgggcg agaggauauu     1080

guguauuccg ucacuuguga acagugcugg ccugagucag gagaaugugg ccccugcgag     1140

gcuagcguga gauacaguga gccaccccac ggucugacca ggacaucugu uaccgugucc     1200

gacuuagaac cucauaugaa uuauacguuc acugucgagg cccggaacgg ggugagcggc     1260

cugguaacau cgcguucuuu ucgcaccgca uccguuucaa ucaaucaaac ugaaccaccg     1320

aaggugagac ucgagggaag gaguacaacc agccuuuccg ucucuuggag cauucccccu     1380

ccacagcagu cacgggugug gaaguacgag gucacguauc gcaaaaaggg cgauaguaac     1440

uccuacaaug ugcgaagaac cgaaggguuc agcguuacac uggacgauuu ggcgcccgac     1500

acuaccuacc uagugcaagu acaggcucug acacaggagg gacagggugc cggcucuaaa     1560

guccacgaau uucaaacucu cucaccugag gggaguggaa accuggcagu gaucggcggu     1620

guugccgugg gggucgugcu ucuguuggua cucgcuggcg ugggauucuu uauacauagg     1680

cggcgcaaga aucagagagc caggcagagc ccagaagaug uuuauuucuc caaaucugag     1740

cagcugaagc ccuuaaaaac cuacgucgac ccgcacacau augaggaucc uaaccaagca     1800

gugcugaagu uuaccacuga aauucaccca ucguguguga cgcgucagaa ggucaucggc     1860

gcuggggagu ucggagaagu uuacaaaggu augcuaaaga caagcuccgg caaaaaggag     1920

gugcccgugg ccauuaaaac ccucaaggcg ggguauacug aaaagcagcg gguagacuuu     1980

cugggagagg ccggcaucau gggucaguuc ucacaucaca acaucauucg acuugagggg     2040

gucauaagua aauacaagcc uaugaugauc auuaccgaau auauggagaa uggcgcuuug     2100

gacaaauuuc ugagagaaaa ggauggagag uucucugugc uccaacuggu uggcaugcuu     2160

agggggaucg cagccggaau gaaauaccug gcuaacauga auuacgugca ucgcgacuug     2220

gccgcacgga acauacucgu caauagcaac cuggugugca agguuuccga uuucggcuua     2280

ucaagagugc uggaagacga ucccgaggcg acauauacca cuagcggugg gaagauucca     2340

aucaggugga cagccccuga ggcuaucucu uaccgcaaau uuacguccgc cagugacgua     2400

uggagcuucg gaauugucau gugggaagug augaccuaug gcgagcgacc cuacugggaa     2460

cuaucuaauc acgaggugau gaaggcaauc aacgaugguu uucggcuccc aacuccgaug     2520

gacuguccuu ccgcuauuua ucagcugaug augcagugcu ggcagcaaga gcgugccaga     2580

aggcccaaau ucgcagauau agucucaauc cuugacaagu ugauucgcgc cccagauagu     2640

cugaaaacac ucgcugacuu ugauccccgg guuagcauca gacugccuuc gaccuccggc     2700

ucugaagggg ugccauucag gacaguaagc gagugguuag aaucaaucaa gaugcagcag     2760

uacacugagc auuuuauggc ggccggauau accgcaauug aaaagguggu ccaaaugacg     2820

aaugacgaca uaaaacgaau cggcgugcgc cugcccgggc accagaagcg gauugcuuac     2880

agucuuuugg gacucaaaga ucagguuaac accgugggca ucccuauuug a              2931


<210>  1432
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EphA2__Homo_sapiens__CCDS169.1

<400>  1432
auggagcugc aggccgccag agccugcuuc gcccugcugu ggggcugcgc ccuggccgcc       60

gccgccgccg cccagggcaa ggagguggug cugcuggacu ucgccgccgc cggcggcgag      120

cugggcuggc ugacccaccc cuacggcaag ggcugggacc ugaugcagaa caucaugaac      180

gacaugccca ucuacaugua cagcgugugc aacgugauga gcggcgacca ggacaacugg      240

cugagaacca acugggugua cagaggcgag gccgagagaa ucuucaucga gcugaaguuc      300

accgugagag acugcaacag cuuccccggc ggcgccagca gcugcaagga gaccuucaac      360

cuguacuacg ccgagagcga ccuggacuac ggcaccaacu uccagaagag acuguucacc      420

aagaucgaca ccaucgcccc cgacgagauc accgugagca gcgacuucga ggccagacac      480

gugaagcuga acguggagga gagaagcgug ggcccccuga ccagaaaggg cuucuaccug      540

gccuuccagg acaucggcgc cugcguggcc cugcugagcg ugagagugua cuacaagaag      600

ugccccgagc ugcugcaggg ccuggcccac uuccccgaga ccaucgccgg cagcgacgcc      660

cccagccugg ccaccguggc cggcaccugc guggaccacg ccguggugcc ccccggcggc      720

gaggagccca gaaugcacug cgccguggac ggcgaguggc uggugcccau cggccagugc      780

cugugccagg ccggcuacga gaagguggag gacgccugcc aggccugcag ccccggcuuc      840

uucaaguucg aggccagcga gagccccugc cuggagugcc ccgagcacac ccugcccagc      900

cccgagggcg ccaccagcug cgagugcgag gagggcuucu ucagagcccc ccaggacccc      960

gccagcaugc ccugcaccag accccccagc gccccccacu accugaccgc cgugggcaug     1020

ggcgccaagg uggagcugag auggaccccc ccccaggaca gcggcggcag agaggacauc     1080

guguacagcg ugaccugcga gcagugcugg cccgagagcg gcgagugcgg ccccugcgag     1140

gccagcguga gauacagcga gcccccccac ggccugacca gaaccagcgu gaccgugagc     1200

gaccuggagc cccacaugaa cuacaccuuc accguggagg ccagaaacgg cgugagcggc     1260

cuggugacca gcagaagcuu cagaaccgcc agcgugagca ucaaccagac cgagcccccc     1320

aaggugagac uggagggcag aagcaccacc agccugagcg ugagcuggag cauccccccc     1380

ccccagcaga gcagagugug gaaguacgag gugaccuaca gaaagaaggg cgacagcaac     1440

agcuacaacg ugagaagaac cgagggcuuc agcgugaccc uggacgaccu ggcccccgac     1500

accaccuacc uggugcaggu gcaggcccug acccaggagg gccagggcgc cggcagcaag     1560

gugcacgagu uccagacccu gagccccgag ggcagcggca accuggccgu gaucggcggc     1620

guggccgugg gcguggugcu gcugcuggug cuggccggcg ugggcuucuu cauccacaga     1680

agaagaaaga accagagagc cagacagagc cccgaggacg uguacuucag caagagcgag     1740

cagcugaagc cccugaagac cuacguggac ccccacaccu acgaggaccc caaccaggcc     1800

gugcugaagu ucaccaccga gauccacccc agcugcguga ccagacagaa ggugaucggc     1860

gccggcgagu ucggcgaggu guacaagggc augcugaaga ccagcagcgg caagaaggag     1920

gugcccgugg ccaucaagac ccugaaggcc ggcuacaccg agaagcagag aguggacuuc     1980

cugggcgagg ccggcaucau gggccaguuc agccaccaca acaucaucag acuggagggc     2040

gugaucagca aguacaagcc caugaugauc aucaccgagu acauggagaa cggcgcccug     2100

gacaaguucc ugagagagaa ggacggcgag uucagcgugc ugcagcuggu gggcaugcug     2160

agaggcaucg ccgccggcau gaaguaccug gccaacauga acuacgugca cagagaccug     2220

gccgccagaa acauccuggu gaacagcaac cuggugugca aggugagcga cuucggccug     2280

agcagagugc uggaggacga ccccgaggcc accuacacca ccagcggcgg caagaucccc     2340

aucagaugga ccgcccccga ggccaucagc uacagaaagu ucaccagcgc cagcgacgug     2400

uggagcuucg gcaucgugau gugggaggug augaccuacg gcgagagacc cuacugggag     2460

cugagcaacc acgaggugau gaaggccauc aacgacggcu ucagacugcc cacccccaug     2520

gacugcccca gcgccaucua ccagcugaug augcagugcu ggcagcagga gagagccaga     2580

agacccaagu ucgccgacau cgugagcauc cuggacaagc ugaucagagc ccccgacagc     2640

cugaagaccc uggccgacuu cgaccccaga gugagcauca gacugcccag caccagcggc     2700

agcgagggcg ugcccuucag aaccgugagc gaguggcugg agagcaucaa gaugcagcag     2760

uacaccgagc acuucauggc cgccggcuac accgccaucg agaagguggu gcagaugacc     2820

aacgacgaca ucaagagaau cggcgugaga cugcccggcc accagaagag aaucgccuac     2880

agccugcugg gccugaagga ccaggugaac accgugggca uccccaucug a              2931


<210>  1433
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EphA2__Homo_sapiens__CCDS169.1

<400>  1433
auggagcugc aggccgcuag agccugcuuc gcgcuccugu ggggcugugc ucuugccgcc       60

gcugccgcug cccaagggaa ggaagugguc cugcucgacu uugcggccgc uggaggcgag      120

cugggguggc uuacccaccc cuacggaaaa ggcugggauc ugaugcagaa caucaugaau      180

gacaugccua uuuauaugua cagcguuugc aacgugaugu ccggggauca ggacaauugg      240

cuccggacaa acugggugua ucgcggagaa gccgagagaa ucuucauuga acugaaguuu      300

acgguccggg auuguaauuc uuucccgggc ggcgcuagcu ccugcaaaga gaccuuuaac      360

cuguacuaug ccgagucuga ccucgauuac gggacaaauu uccagaagcg ccuguuuacc      420

aaaaucgaca caauugcgcc cgaugaaauc accgugagcu ccgacuucga ggccagacau      480

guuaaacuua acguggaaga gagaucuguc ggaccucuga cacgcaaggg cuuuuaucuc      540

gcuuuccaag auaucggggc cuguguggcu cugcuuagcg uuagagugua cuacaaaaag      600

ugccccgagc ugcuccaggg acuggcccac uuuccugaaa ccauugccgg cuccgacgcu      660

cccagccugg cgacggucgc cgggaccugu guggaucaug cugugguccc uccgggaggc      720

gaggaacccc ggaugcacug cgccguugac ggcgaguggc ucgugccuau cgggcagugu      780

cugugccagg ccggauauga aaaaguggag gacgcuuguc aagccugcuc ucccggcuuc      840

uuuaaguucg aggcguccga aagcccuugc cuugaguguc ccgaacauac acugccgucu      900

ccugaggggg cuaccuccug cgaaugugag gagggauucu uucgcgcucc ccaggauccu      960

gccagcaugc ccugcacaag acccccuucu gccccgcacu accucaccgc cgucggcaug     1020

ggggcuaaag uggaacugcg guggacgccc ccucaggacu ccggaggccg cgaggauauu     1080

guuuauagcg ugacauguga acagugcugg cccgaguccg gcgaaugugg gccuugcgag     1140

gccucuguca gauacagcga gcccccgcac ggacuuaccc ggacauccgu gaccguuagc     1200

gaccuggaac cucauaugaa uuauaccuuc acaguggagg cgcgcaacgg cgucucuggg     1260

cucgugacgu cccggagcuu ucggaccgcc ucugucagca ucaaucaaac agaacccccu     1320

aaggugagac uggagggacg cuccaccaca ucucugagcg uuuccuggag cauucccccu     1380

ccccagcagu cucgggugug gaaguacgag gucaccuaua gaaagaaggg cgauuccaac     1440

agcuacaaug ugcgccggac ggaaggguuc ucuguuacac ucgacgaucu ggcuccggac     1500

accaccuacc uugugcaagu ccaggcccug acacaggagg gccagggagc uggcuccaaa     1560

gugcacgaau uucaaacccu cagcccugag ggguccggaa accuggccgu gaucggcggg     1620

guugcggucg gaguggugcu ucugcucguc cuggccggcg ugggguucuu uauucauaga     1680

cgccggaaga aucagagagc ucgccagucu cccgaagaug uuuauuucag caaauccgag     1740

cagcugaagc cccucaaaac auacguggac ccucacacgu augaggaucc gaaccaagcc     1800

guccugaagu uuaccacaga aauccacccc ucuuguguga cccggcagaa gguuaucggc     1860

gcuggagagu ucggcgaagu guacaaaggg augcuuaaga caagcuccgg caaaaaggag     1920

gucccugugg ccauuaaaac ccugaaggcc ggauauacgg aaaagcagag aguugacuuu     1980

cucggggagg cuggaaucau gggccaguuc agccaucaca acauuauccg ccuggagggg     2040

gugauuucua aauacaagcc caugaugauc aucaccgaau auauggagaa uggcgcgcug     2100

gacaaauuuc uucgggaaaa ggauggagag uucuccgucc uccaacuggu gggcaugcug     2160

agagggauug ccgcuggaau gaaauaccuc gccaacauga auuacgugca ucgggaccug     2220

gccgcucgca acauccuugu caauagcaac cugguuugca aggugucuga uuucggccuc     2280

uccagagugc uggaagacga uccugaggcc acauauacca caagcggggg aaagauuccc     2340

auccggugga ccgcgccuga ggcuauuucu uacagaaaau uuacgagcgc cuccgacguc     2400

uggagcuucg gcaucgugau gugggaaguu augacauaug gggagcgccc cuacugggaa     2460

cugucuaauc acgaggugau gaaggccauc aacgauggcu uucggcuucc gaccccuaug     2520

gacugucccu ccgcuauuua ucagcucaug augcagugcu ggcagcaaga gagagcccgc     2580

agaccuaaau ucgcggauau cgucagcauu cuggacaagc ugauccgggc ucccgauucc     2640

cucaaaacac uggccgacuu ugauccgcgc gugucuauua gacuuccuag caccuccgga     2700

ucugaaggcg uucccuuccg gaccgugagc gaguggcugg aauccaucaa gaugcagcag     2760

uacacagagc auuuuauggc cgcuggguau acggccauug aaaaggucgu gcaaaugacc     2820

aaugacgaca ucaaacgcau cggaguuaga cucccuggcc accagaagcg gauugcuuac     2880

ucucugcugg ggcuuaaaga ucaggugaac acagucggaa uccccauuug a              2931


<210>  1434
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EphA3__Homo_sapiens__P29320

<400>  1434

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  1435
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EphA3__Homo_sapiens__AAG43576

<400>  1435
auggauuguc agcucuccau ccuccuccuu cucagcugcu cuguucucga cagcuucggg       60

gaacugauuc cgcagccuuc caaugaaguc aaucuacugg auucaaaaac aauucaaggg      120

gagcugggcu ggaucucuua uccaucacau gggugggaag agaucagugg uguggaugaa      180

cauuacacac ccaucaggac uuaccaggug ugcaauguca uggaccacag ucaaaacaau      240

uggcugagaa caaacugggu ccccaggaac ucagcucaga agauuuaugu ggagcucaag      300

uucacucuac gagacugcaa uagcauucca uugguuuuag gaacuugcaa ggagacauuc      360

aaccuguacu acauggaguc ugaugaugau caugggguga aauuucgaga gcaucaguuu      420

acaaagauug acaccauugc agcugaugaa aguuucacuc aaauggaucu uggggaccgu      480

auucugaagc ucaacacuga gauuagagaa guagguccug ucaacaagaa gggauuuuau      540

uuggcauuuc aagauguugg ugcuuguguu gccuuggugu cugugagagu auacuucaaa      600

aagugcccau uuacagugaa gaaucuggcu auguuuccag acacgguacc cauggacucc      660

cagucccugg uggagguuag agggucuugu gucaacaauu cuaaggagga agauccucca      720

aggauguacu gcaguacaga aggcgaaugg cuuguaccca uuggcaagug uuccugcaau      780

gcuggcuaug aagaaagagg uuuuaugugc caagcuuguc gaccagguuu cuacaaggca      840

uuggauggua auaugaagug ugcuaagugc ccgccucaca guucuacuca ggaagauggu      900

ucaaugaacu gcagguguga gaauaauuac uuccgggcag acaaagaccc uccauccaug      960

gcuuguaccc gaccuccauc uucaccaaga aauguuaucu cuaauauaaa cgagaccuca     1020

guuauccugg acuggaguug gccccuggac acaggaggcc ggaaagaugu uaccuucaac     1080

aucauaugua aaaaaugugg guggaauaua aaacagugug agccaugcag cccaaauguc     1140

cgcuuccucc cucgacaguu uggacucacc aacaccacgg ugacagugac agaccuucug     1200

gcacauacua acuacaccuu ugagauugau gccguuaaug gggugucaga gcugagcucc     1260

ccaccaagac aguuugcugc ggucagcauc acaacuaauc aggcugcucc aucaccuguc     1320

cugacgauua agaaagaucg gaccuccaga aauagcaucu cuuuguccug gcaagaaccu     1380

gaacauccua augggaucau auuggacuac gaggucaaau acuaugaaaa gcaggaacaa     1440

gaaacaaguu auaccauucu gagggcaaga ggcacaaaug uuaccaucag uagccucaag     1500

ccugacacua uauacguauu ccaaauccga gcccgaacag ccgcuggaua ugggacgaac     1560

agccgcaagu uugaguuuga aacuagucca gacucuuucu ccaucucugg ugaaaguagc     1620

caagugguca ugaucgccau uucagcggca guagcaauua uucuccucac uguugucauc     1680

uauguuuuga uugggagguu cuguggcuau aagucaaaac auggggcaga ugaaaaaaga     1740

cuucauuuug gcaaugggca uuuaaaacuu ccaggucuca ggacuuaugu ugacccacau     1800

acauaugaag acccuaccca agcuguucau gaguuugcca aggaauugga ugccaccaac     1860

auauccauug auaaaguugu uggagcaggu gaauuuggag aggugugcag uggucgcuua     1920

aaacuuccuu caaaaaaaga gauuucagug gccauuaaga cccugaaagu uggcuacaca     1980

gaaaagcaga ggagagacuu ccugggagaa gcaagcauua ugggacaguu ugaccacccc     2040

aauaucauuc gacuggaagg aguuguuacc aaaaguaagc caguuaugau ugucacagaa     2100

uacauggaga augguuccuu ggauaguuuc cuacguaaac acgaugccca guuuacuguc     2160

auucagcuag uggggaugcu ucgagggaua gcaucuggca ugaaguaccu gucagacaug     2220

ggcuauguuc accgagaccu cgcugcucgg aacaucuuga ucaacaguaa cuuggugugu     2280

aagguuucug auuucggacu uucgcguguc cuggaggaug acccagaagc ugcuuauaca     2340

acaagaggag ggaagauccc aaucaggugg acaucaccag aagcuauagc cuaccgcaag     2400

uucacgucag ccagcgaugu auggaguuau gggauuguuc ucugggaggu gaugucuuau     2460

ggagagagac cauacuggga gauguccaau caggauguaa uuaaagcugu agaugagggc     2520

uaucgacugc caccccccau ggacugccca gcugccuugu aucagcugau gcuggacugc     2580

uggcagaaag acaggaacaa cagacccaag uuugagcaga uuguuaguau ucuggacaag     2640

cuuauccgga aucccggcag ccugaagauc aucaccagug cagccgcaag gccaucaaac     2700

cuucuucugg accaaagcaa uguggauauc acuaccuucc gcacaacagg ugacuggcuu     2760

aauggugucu ggacagcaca cugcaaggaa aucuucacgg guguggagua caguucuugu     2820

gacacaauag ccaagauuuc cacagaugac augaaaaagg uuggugucac cgugguuggg     2880

ccacagaaga agaucaucag uagcauuaaa gcucuagaaa cgcaaucaaa gaauggccca     2940

guucccgugu aa                                                         2952


<210>  1436
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EphA3__Homo_sapiens__AAG43576

<400>  1436
auggacugcc agcugagcau ccuccugcug cucuccugca gcgugcugga cuccuucggc       60

gagcugaucc cccagccgag caacgagguc aaccuccugg acuccaagac cauccagggg      120

gagcugggcu ggaucagcua ccccucccac gggugggagg agaucagcgg cguggacgag      180

cacuacaccc ccauccgcac guaccaggug ugcaacguca uggaccacuc ccagaacaac      240

uggcuccgga ccaacugggu gccccgcaac agcgcccaga agaucuacgu ggagcugaag      300

uucacccugc gggacugcaa cuccaucccg cucguccugg ggaccugcaa ggagacguuc      360

aaccuguacu acauggagag cgacgacgac cacggcguga aguuccgcga gcaccaguuc      420

accaagaucg acaccaucgc cgcggacgag uccuucaccc agauggaccu cggcgaccgg      480

auccugaagc ugaacacgga gauccgcgag guggggcccg ucaacaagaa gggcuucuac      540

cucgccuucc aggacguggg ggccugcgug gcccugguca gcgugcgggu guacuucaag      600

aagugccccu ucaccgucaa gaaccuggcc auguuccccg acaccgugcc gauggacucc      660

cagagccucg uggagguccg cggcuccugc gugaacaaca gcaaggagga ggacccgccc      720

cggauguacu gcuccaccga gggggagugg cuggugccca ucggcaagug cagcugcaac      780

gcgggcuacg aggagcgcgg guucaugugc caggccugcc ggcccggcuu cuacaaggcc      840

cuggacggga acaugaagug cgccaagugc ccgccccaca gcuccacgca ggaggacggc      900

agcaugaacu gccgcugcga gaacaacuac uuccgggcgg acaaggaccc gcccuccaug      960

gccugcaccc gcccgcccag cagcccccgg aacgucaucu ccaacaucaa cgagaccucc     1020

gugauccucg acuggagcug gccccuggac accggcgggc gcaaggacgu gacguucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcuc ccccaacguc     1140

cgguuccugc cccgccaguu cgggcucacc aacaccaccg ugacggucac cgaccugcug     1200

gcccacacca acuacaccuu cgagaucgac gccgugaacg gcgugagcga gcucuccagc     1260

ccgccccggc aguucgccgc ggucuccauc acgaccaacc aggccgcccc cagccccgug     1320

cugaccauca agaaggaccg caccucccgg aacagcaucu cccugagcug gcaggagccc     1380

gagcacccca acgggaucau ccucgacuac gaggugaagu acuacgagaa gcaggagcag     1440

gagacguccu acaccauccu gcgcgcccgc ggcaccaacg ucaccaucag cagccugaag     1500

cccgacacga ucuacguguu ccagauccgg gcccgcaccg cggccggcua cgggaccaac     1560

ucccggaagu ucgaguucga gaccagcccg gacuccuuca gcaucuccgg cgagagcucc     1620

caggugguca ugaucgccau cagcgccgcc guggcgauca uccuccugac gguggucauc     1680

uacgugcuga ucgggcgcuu cugcggcuac aaguccaagc acggggccga cgagaagcgg     1740

cuccacuucg gcaacggcca ccugaagcug cccgggcucc gcaccuacgu ggacccccac     1800

accuacgagg accccaccca ggccguccac gaguucgcca aggagcugga cgccaccaac     1860

aucagcaucg acaagguggu gggcgcgggg gaguucggcg aggucugcuc cgggcggcug     1920

aagcucccga gcaagaagga gaucuccgug gccaucaaga cgcugaaggu gggcuacacc     1980

gagaagcagc gccgggacuu ccugggcgag gccagcauca uggggcaguu cgaccacccc     2040

aacaucaucc gccucgaggg cgucgugacc aaguccaagc ccgugaugau cgucaccgag     2100

uacauggaga acgggagccu ggacuccuuc cugcggaagc acgacgccca guucacggug     2160

auccagcugg ugggcaugcu ccgcggcauc gcgagcggga ugaaguaccu gagcgacaug     2220

ggcuacgucc accgggaccu ggccgcccgc aacauccuca ucaacuccaa ccuggugugc     2280

aaggugagcg acuucgggcu gucccggguc cucgaggacg accccgaggc cgccuacacc     2340

acccgcggcg ggaagauccc gauccggugg accagccccg aggcgaucgc cuaccgcaag     2400

uucacguccg ccagcgacgu gugguccuac ggcaucgugc ugugggaggu caugagcuac     2460

ggcgagcggc ccuacuggga gauguccaac caggacguga ucaaggccgu ggacgagggg     2520

uaccgccugc ccccgcccau ggacugcccc gccgcgcucu accagcugau gcuggacugc     2580

uggcagaagg accgcaacaa ccggcccaag uucgagcaga ucgucagcau ccucgacaag     2640

cugauccgca acccgggcuc ccugaagauc aucaccagcg ccgccgcccg gcccuccaac     2700

cuccugcugg accagagcaa cguggacauc accaccuucc gcacgaccgg ggacuggcuc     2760

aacggcgugu ggaccgccca cugcaaggag aucuucaccg gggucgagua cuccagcugc     2820

gacacgaucg cgaagaucuc caccgacgac augaagaagg ugggcgugac cgucgugggc     2880

ccccagaaga agaucaucag cuccaucaag gcccuggaga cccagagcaa gaacgggccc     2940

gugccggucu ga                                                         2952


<210>  1437
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EphA3__Homo_sapiens__AAG43576

<400>  1437
auggacugcc agcucuccau ccuccuccuc cucuccugcu ccguccucga cuccuucggc       60

gagcucaucc cccagcccuc caacgagguc aaccuccucg acuccaagac cauccagggc      120

gagcucggcu ggaucuccua ccccucccac ggcugggagg agaucuccgg cgucgacgag      180

cacuacaccc ccauccgcac cuaccagguc ugcaacguca uggaccacuc ccagaacaac      240

uggcuccgca ccaacugggu cccccgcaac uccgcccaga agaucuacgu cgagcucaag      300

uucacccucc gcgacugcaa cuccaucccc cucguccucg gcaccugcaa ggagaccuuc      360

aaccucuacu acauggaguc cgacgacgac cacggcguca aguuccgcga gcaccaguuc      420

accaagaucg acaccaucgc cgccgacgag uccuucaccc agauggaccu cggcgaccgc      480

auccucaagc ucaacaccga gauccgcgag gucggccccg ucaacaagaa gggcuucuac      540

cucgccuucc aggacgucgg cgccugcguc gcccucgucu ccguccgcgu cuacuucaag      600

aagugccccu ucaccgucaa gaaccucgcc auguuccccg acaccguccc cauggacucc      660

cagucccucg ucgagguccg cggcuccugc gucaacaacu ccaaggagga ggaccccccc      720

cgcauguacu gcuccaccga gggcgagugg cucgucccca ucggcaagug cuccugcaac      780

gccggcuacg aggagcgcgg cuucaugugc caggccugcc gccccggcuu cuacaaggcc      840

cucgacggca acaugaagug cgccaagugc cccccccacu ccuccaccca ggaggacggc      900

uccaugaacu gccgcugcga gaacaacuac uuccgcgccg acaaggaccc ccccuccaug      960

gccugcaccc gcccccccuc cuccccccgc aacgucaucu ccaacaucaa cgagaccucc     1020

gucauccucg acugguccug gccccucgac accggcggcc gcaaggacgu caccuucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcuc ccccaacguc     1140

cgcuuccucc cccgccaguu cggccucacc aacaccaccg ucaccgucac cgaccuccuc     1200

gcccacacca acuacaccuu cgagaucgac gccgucaacg gcgucuccga gcucuccucc     1260

cccccccgcc aguucgccgc cgucuccauc accaccaacc aggccgcccc cucccccguc     1320

cucaccauca agaaggaccg caccucccgc aacuccaucu cccucuccug gcaggagccc     1380

gagcacccca acggcaucau ccucgacuac gaggucaagu acuacgagaa gcaggagcag     1440

gagaccuccu acaccauccu ccgcgcccgc ggcaccaacg ucaccaucuc cucccucaag     1500

cccgacacca ucuacgucuu ccagauccgc gcccgcaccg ccgccggcua cggcaccaac     1560

ucccgcaagu ucgaguucga gaccuccccc gacuccuucu ccaucuccgg cgaguccucc     1620

caggucguca ugaucgccau cuccgccgcc gucgccauca uccuccucac cgucgucauc     1680

uacguccuca ucggccgcuu cugcggcuac aaguccaagc acggcgccga cgagaagcgc     1740

cuccacuucg gcaacggcca ccucaagcuc cccggccucc gcaccuacgu cgacccccac     1800

accuacgagg accccaccca ggccguccac gaguucgcca aggagcucga cgccaccaac     1860

aucuccaucg acaaggucgu cggcgccggc gaguucggcg aggucugcuc cggccgccuc     1920

aagcuccccu ccaagaagga gaucuccguc gccaucaaga cccucaaggu cggcuacacc     1980

gagaagcagc gccgcgacuu ccucggcgag gccuccauca ugggccaguu cgaccacccc     2040

aacaucaucc gccucgaggg cgucgucacc aaguccaagc ccgucaugau cgucaccgag     2100

uacauggaga acggcucccu cgacuccuuc cuccgcaagc acgacgccca guucaccguc     2160

auccagcucg ucggcaugcu ccgcggcauc gccuccggca ugaaguaccu cuccgacaug     2220

ggcuacgucc accgcgaccu cgccgcccgc aacauccuca ucaacuccaa ccucgucugc     2280

aaggucuccg acuucggccu cucccgcguc cucgaggacg accccgaggc cgccuacacc     2340

acccgcggcg gcaagauccc cauccgcugg accucccccg aggccaucgc cuaccgcaag     2400

uucaccuccg ccuccgacgu cugguccuac ggcaucgucc ucugggaggu cauguccuac     2460

ggcgagcgcc ccuacuggga gauguccaac caggacguca ucaaggccgu cgacgagggc     2520

uaccgccucc ccccccccau ggacugcccc gccgcccucu accagcucau gcucgacugc     2580

uggcagaagg accgcaacaa ccgccccaag uucgagcaga ucgucuccau ccucgacaag     2640

cucauccgca accccggcuc ccucaagauc aucaccuccg ccgccgcccg ccccuccaac     2700

cuccuccucg accaguccaa cgucgacauc accaccuucc gcaccaccgg cgacuggcuc     2760

aacggcgucu ggaccgccca cugcaaggag aucuucaccg gcgucgagua cuccuccugc     2820

gacaccaucg ccaagaucuc caccgacgac augaagaagg ucggcgucac cgucgucggc     2880

ccccagaaga agaucaucuc cuccaucaag gcccucgaga cccaguccaa gaacggcccc     2940

guccccgucu ga                                                         2952


<210>  1438
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EphA3__Homo_sapiens__AAG43576

<400>  1438
auggacugcc agcugagcau ccuccuucug uuguccuguu cuguguuaga uucauucggc       60

gagcugauuc cccaaccuag uaacgaaguc aaucuacucg acagcaagac cauacagggg      120

gagcugggau ggaucuccua cccaucucac gguugggaag agauuucggg cguugaugaa      180

cauuauacac cgaucagaac uuaccaggug ugcaacguaa uggaccacuc acagaauaac      240

uggcuuagga cgaauugggu gccccggaac agcgcccaga aaauuuaugu cgagcugaag      300

uuuaccuugc gcgauuguaa uaguaucccu cucgugcugg ggacaugcaa agagacuuuc      360

aaccuguacu auauggaauc cgacgaugac cauggaguua aguuucgaga gcaccaauuc      420

accaaaauag auacaaucgc ugcagacgaa ucuuuuaccc agauggaucu cggcgaccgu      480

auuuuaaagc ugaauacuga gaucagagag guggguccag ucaacaagaa aggguucuac      540

cuugccuuuc aggauguggg agcgugugua gcuuugguua gcgugagggu cuauuucaag      600

aaaugccccu uuacagugaa gaaucuggcc auguucccug acaccgugcc aauggacucc      660

caaagucuag ucgaaguucg gggcucaugu gugaacaaua gcaaagagga agaucccccu      720

cgcauguacu gcucuacgga gggcgaaugg cucguaccaa uugggaagug uuccugcaac      780

gcaggauacg aggagagagg uuuuaugugu caggccugca ggccgggcuu cuauaaggcu      840

cuggacggga auaugaaaug cgcaaagugu cccccucauu caagcacuca ggaagaugga      900

aguaugaacu gccgguguga gaacaauuac uuucgcgccg acaaagaucc acccucuaug      960

gcuugcaccc gaccuccauc cagccccaga aacgugaucu cgaauauaaa cgaaacaucu     1020

gucauucuug acugguccug gccgcuggau acuggcggua ggaaggacgu gaccuucaau     1080

aucauuugua aaaagugcgg guggaacauc aaacagugug agccuugcuc acccaauguu     1140

cgguucuugc cacgucaauu uggacucaca aacaccacgg ugacugucac agaucuguua     1200

gcccacacca auuauacuuu cgaaaucgac gcggugaacg gcguaaguga gcugagcucc     1260

ccuccccgcc aguuugcagc cguuucuauu acaaccaauc aggcugcccc aagccccgug     1320

cucacgauaa agaaggauag aaccucaagg aacaguaucu cccuuagcug gcaagagccu     1380

gaacacccaa auggcauuau ccuggacuac gaggucaaau auuacgaaaa gcaggagcag     1440

gaaacaucuu auacuauauu gcgggcacga gggaccaacg ugacaauuuc aagucuaaaa     1500

ccggacacua ucuacgucuu ccagauccgc gcuagaaccg ccgcgggaua cgguacaaau     1560

agcaggaagu uugaguucga gaccuccccc gauucuuuuu cgauuagcgg cgaauccuca     1620

caagugguua ugaucgccau uagugcagcu guggccauaa uccugcucac uguagucauu     1680

uaugugcuga ucgggcgguu cuguggauac aaaucuaagc auggcgcuga cgagaagcgc     1740

cuucacuuug guaacgggca ucugaaauug ccuggccuca gaacguaugu ugauccacac     1800

acauacgaag accccaccca ggccgugcac gaguucgcaa aggagcugga ugccacuaac     1860

aucagcauug acaaagucgu gggagcuggc gaauuugggg agguaugcuc cggaagguua     1920

aagcugccua gcaaaaagga aauaucagug gcgaucaaga cccuaaaagu ugguuauaca     1980

gagaagcagc gucgggauuu ccucggcgaa gcaucuauua uggggcaguu ugaccaucca     2040

aauaucauuc gacuggaggg agucgugacc aaauccaagc ccgugaugau cgucacugag     2100

uacauggaaa acggcagucu ugauagcuuc uugagaaaac acgacgccca auucacaguu     2160

auacagcugg uggguaugcu cagggggauc gcuucuggca ugaaguaucu guccgauaug     2220

ggauacgugc aucgcgaccu ugccgcacgg aauauucuga ucaacucaaa uuugguaugu     2280

aaggucagug auuuuggccu cagcagagug cuggaggacg acccggaagc cgcuuacacg     2340

acccgcgggg gaaaaauucc uaucaggugg acuucgccag aggccauagc auaucgaaag     2400

uucacauccg cgucugaugu uuggagcuac gguauugugu uaugggaagu caugucauau     2460

ggcgagcggc ccuacuggga gaugaguaac caggacguga ucaaagcugu ugaugaaggg     2520

uaucgucugc cucccccaau ggacugcccu gccgcacuau accagcucau gcuggauugc     2580

uggcaaaagg acagaaauaa caggcccaaa uuugagcaga uuguguccau ccuugauaag     2640

uugauacgca auccaggauc ucugaaaauc auuaccagcg ccgcugcccg gccguccaac     2700

cuccuguuag accagucaaa uguagauauc acaacuuuca gaaccacggg cgacuggcug     2760

aacggugucu ggaccgcaca cuguaaggaa auuuuuacag ggguggagua uagcaguugc     2820

gauacuaucg cuaagauauc uaccgacgau augaaaaagg ugggcgucac aguuguggga     2880

ccucagaaaa agauuaucuc cagcaucaaa gcccuugaaa cucaaucgaa gaauggcccc     2940

guaccagugu ga                                                         2952


<210>  1439
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EphA3__Homo_sapiens__AAG43576

<400>  1439
auggacugcc agcugagcau ccugcugcug cugagcugca gcgugcugga cagcuucggc       60

gagcugaucc cccagcccag caacgaggug aaccugcugg acagcaagac cauccagggc      120

gagcugggcu ggaucagcua ccccagccac ggcugggagg agaucagcgg cguggacgag      180

cacuacaccc ccaucagaac cuaccaggug ugcaacguga uggaccacag ccagaacaac      240

uggcugagaa ccaacugggu gcccagaaac agcgcccaga agaucuacgu ggagcugaag      300

uucacccuga gagacugcaa cagcaucccc cuggugcugg gcaccugcaa ggagaccuuc      360

aaccuguacu acauggagag cgacgacgac cacggcguga aguucagaga gcaccaguuc      420

accaagaucg acaccaucgc cgccgacgag agcuucaccc agauggaccu gggcgacaga      480

auccugaagc ugaacaccga gaucagagag gugggccccg ugaacaagaa gggcuucuac      540

cuggccuucc aggacguggg cgccugcgug gcccugguga gcgugagagu guacuucaag      600

aagugccccu ucaccgugaa gaaccuggcc auguuccccg acaccgugcc cauggacagc      660

cagagccugg uggaggugag aggcagcugc gugaacaaca gcaaggagga ggaccccccc      720

agaauguacu gcagcaccga gggcgagugg cuggugccca ucggcaagug cagcugcaac      780

gccggcuacg aggagagagg cuucaugugc caggccugca gacccggcuu cuacaaggcc      840

cuggacggca acaugaagug cgccaagugc cccccccaca gcagcaccca ggaggacggc      900

agcaugaacu gcagaugcga gaacaacuac uucagagccg acaaggaccc ccccagcaug      960

gccugcacca gaccccccag cagccccaga aacgugauca gcaacaucaa cgagaccagc     1020

gugauccugg acuggagcug gccccuggac accggcggca gaaaggacgu gaccuucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcag ccccaacgug     1140

agauuccugc ccagacaguu cggccugacc aacaccaccg ugaccgugac cgaccugcug     1200

gcccacacca acuacaccuu cgagaucgac gccgugaacg gcgugagcga gcugagcagc     1260

ccccccagac aguucgccgc cgugagcauc accaccaacc aggccgcccc cagccccgug     1320

cugaccauca agaaggacag aaccagcaga aacagcauca gccugagcug gcaggagccc     1380

gagcacccca acggcaucau ccuggacuac gaggugaagu acuacgagaa gcaggagcag     1440

gagaccagcu acaccauccu gagagccaga ggcaccaacg ugaccaucag cagccugaag     1500

cccgacacca ucuacguguu ccagaucaga gccagaaccg ccgccggcua cggcaccaac     1560

agcagaaagu ucgaguucga gaccagcccc gacagcuuca gcaucagcgg cgagagcagc     1620

caggugguga ugaucgccau cagcgccgcc guggccauca uccugcugac cguggugauc     1680

uacgugcuga ucggcagauu cugcggcuac aagagcaagc acggcgccga cgagaagaga     1740

cugcacuucg gcaacggcca ccugaagcug cccggccuga gaaccuacgu ggacccccac     1800

accuacgagg accccaccca ggccgugcac gaguucgcca aggagcugga cgccaccaac     1860

aucagcaucg acaagguggu gggcgccggc gaguucggcg aggugugcag cggcagacug     1920

aagcugccca gcaagaagga gaucagcgug gccaucaaga cccugaaggu gggcuacacc     1980

gagaagcaga gaagagacuu ccugggcgag gccagcauca ugggccaguu cgaccacccc     2040

aacaucauca gacuggaggg cguggugacc aagagcaagc ccgugaugau cgugaccgag     2100

uacauggaga acggcagccu ggacagcuuc cugagaaagc acgacgccca guucaccgug     2160

auccagcugg ugggcaugcu gagaggcauc gccagcggca ugaaguaccu gagcgacaug     2220

ggcuacgugc acagagaccu ggccgccaga aacauccuga ucaacagcaa ccuggugugc     2280

aaggugagcg acuucggccu gagcagagug cuggaggacg accccgaggc cgccuacacc     2340

accagaggcg gcaagauccc caucagaugg accagccccg aggccaucgc cuacagaaag     2400

uucaccagcg ccagcgacgu guggagcuac ggcaucgugc ugugggaggu gaugagcuac     2460

ggcgagagac ccuacuggga gaugagcaac caggacguga ucaaggccgu ggacgagggc     2520

uacagacugc ccccccccau ggacugcccc gccgcccugu accagcugau gcuggacugc     2580

uggcagaagg acagaaacaa cagacccaag uucgagcaga ucgugagcau ccuggacaag     2640

cugaucagaa accccggcag ccugaagauc aucaccagcg ccgccgccag acccagcaac     2700

cugcugcugg accagagcaa cguggacauc accaccuuca gaaccaccgg cgacuggcug     2760

aacggcgugu ggaccgccca cugcaaggag aucuucaccg gcguggagua cagcagcugc     2820

gacaccaucg ccaagaucag caccgacgac augaagaagg ugggcgugac cguggugggc     2880

ccccagaaga agaucaucag cagcaucaag gcccuggaga cccagagcaa gaacggcccc     2940

gugcccgugu ga                                                         2952


<210>  1440
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EphA3__Homo_sapiens__AAG43576

<400>  1440
auggacugcc agcugagcau ccuccugcuu cuguccuguu cugugcucga uagcuucggc       60

gagcugauuc cccaaccuuc caacgaaguc aaucuucugg acucuaagac cauccagggg      120

gagcucggau ggauuagcua cccgucccac ggcugggaag agaucucugg gguugaugaa      180

cauuauacac ccauuagaac guaccaggug ugcaacguga uggaccacag ccagaauaac      240

uggcugcgga ccaauugggu cccucgcaac uccgcccaaa agaucuaugu ggagcugaag      300

uuuacacuca gagauuguaa uagcaucccc cugguucuug gaaccugcaa agagacauuc      360

aaccuguacu auauggaauc ugacgaugac cauggcguga aguuucggga gcaccaguuc      420

accaaaauug auacaaucgc ugccgacgaa uccuuuaccc agauggaucu cggggaccgc      480

auucugaaac uuaauacgga gaucagagag gucggaccug ugaacaagaa aggcuucuac      540

cuggcguuuc aggauguugg cgcuugugug gcccucguca gcgugcgggu guauuucaag      600

aaaugccccu uuaccgucaa gaaucuggcc auguucccug acacaguucc gauggacucu      660

caaucccugg uggaagugcg cgggagcugu gucaacaauu cuaaagagga agaucccccu      720

agaauguacu gcuccaccga gggagaaugg cucgugccca uuggcaagug uagcugcaac      780

gcuggguacg aggagcgggg auuuaugugu caggccugcc gcccuggcuu cuauaaggcu      840

cuggacggga auaugaaaug cgccaagugu cccccgcauu ccucuacaca ggaagaugga      900

agcaugaacu gcagauguga gaacaauuac uuucgggcgg acaaagaucc ucccuccaug      960

gccugcaccc gcccucccag cucucccaga aacguuaucu ccaauauuaa cgaaacgagc     1020

gugauccuug acuggucuug gccucuggau acaggcggcc ggaaggacgu caccuucaau     1080

aucauuugua aaaagugcgg guggaacauc aaacagugug agccgugcag ccccaaugug     1140

cgcuuccucc cuagacaauu uggacugaca aacaccaccg uuacagugac ggaucuucug     1200

gcucacacca auuauacauu cgaaauugac gccgucaacg gcguguccga gcucucuucu     1260

cccccucggc aguuugcugc cgucuccauc accacaaauc aggcggcccc cagcccggug     1320

cugaccauua agaaggauag aacgucucgc aacuccauca gccugucuug gcaagagccu     1380

gaacacccca augggaucau ucucgacuac gagguuaaau auuacgaaaa gcaggagcag     1440

gaaacauccu auaccauccu gcgggcuaga ggaaccaacg ugacaauuag cucccuuaaa     1500

ccugacacca ucuacgucuu ccagauucgc gcccggacag cugccggcua cgggaccaau     1560

ucuagaaagu uugaguucga gacgagcccc gauuccuuuu cuaucagcgg agaauccagc     1620

caagugguua ugaucgccau uucugcugcg guggccauca uucugcucac agucgugauc     1680

uaugugcuga uuggccgcuu cuguggcuac aaauccaagc auggggcuga cgagaagcgg     1740

cuucacuuug gaaacggcca ucugaaacuc ccugggcuga gaaccuaugu ugauccccac     1800

acauacgaag acccgaccca ggccguccac gaguucgcca aggagcugga ugcuacgaac     1860

aucagcauug acaaaguggu gggagccggc gaauuugggg aggucugcuc uggccgccuc     1920

aagcugccuu ccaaaaagga aaucagcgug gcgaucaaga cccuuaaagu uggauauaca     1980

gagaagcagc ggagagauuu ccugggcgaa gcuagcauua uggggcaguu ugaccauccc     2040

aauaucauuc gccucgaggg aguggucacc aaaagcaagc ccgugaugau cguuacagag     2100

uacauggaaa acggcucccu ggauagcuuc cugcggaaac acgacgccca auucaccgug     2160

auucagcuug ucgggaugcu cagaggaauc gccucuggca ugaaguaucu guccgauaug     2220

ggguacgugc aucgggaccu ggcugcccgc aauauccuca uuaacagcaa ucugguuugu     2280

aagguguccg auuuuggccu uucuagaguc cuggaggacg acccugaagc ugccuacacg     2340

acacggggag gcaaaauccc gauuagaugg accagccccg aggcgaucgc cuaucgcaag     2400

uucacauccg cuucugaugu guggagcuac gggauugugc ucugggaagu cauguccuau     2460

ggagagcggc cuuacuggga gaugucuaac caggacguua ucaaagccgu ggaugaaggc     2520

uauagacugc ccccucccau ggacugcccu gcugcccugu accagcuuau gcucgauugc     2580

uggcaaaagg accgcaauaa cagacccaaa uuugagcaga ucgugagcau ucuggauaag     2640

cugauccgga auccgggguc ccucaaaauu aucaccagcg cggccgcucg cccuucuaac     2700

cugcuucugg accaguccaa ugucgauauu accacauuca gaacgaccgg agacuggcuc     2760

aacggcgugu ggacagccca cuguaaggaa aucuuuaccg ggguugagua uagcucuugc     2820

gauacaaucg cuaagauuuc caccgacgau augaaaaagg ugggcgucac ggugguugga     2880

ccccagaaaa agaucauuag cucuaucaaa gcccuggaaa cacaauccaa gaauggcccu     2940

gugcccgucu ga                                                         2952


<210>  1441
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EphA3__Homo_sapiens__Q6P4R6

<400>  1441

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Thr 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  1442
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EphA3__Homo_sapiens__AAH63282

<400>  1442
auggauuguc agcucuccau ccuccuccuu cucagcugcu cuguucucga cagcuucggg       60

gaacugauuc cgcagccuuc caaugaaguc aaucuacugg auucaaaaac aauucaaggg      120

gagcugggcu ggaucucuua uccaucacau gggugggaag agaucagugg uguggaugaa      180

cauuacacac ccaucaggac uuaccaggug ugcaauguca uggaccacag ucaaaacaau      240

uggcugagaa caaacugggu ccccaggaac ucagcucaga agauuuaugu ggagcucaag      300

uucacucuac gagacugcaa uagcauucca uugguuuuag gaacuugcaa ggagacauuc      360

aaccuguacu acauggaguc ugaugaugau caugggguga aauuucgaga gcaucaguuu      420

acaaagauug acaccauugc agcugaugaa aguuucacuc aaauggaucu uggggaccgu      480

auucugaagc ucaacacuga gauuagagaa guagguccug ucaacaagaa gggauuuuau      540

uuggcauuuc aagauguugg ugcuuguguu gccuuggugu cugugagagu auacuucaaa      600

aagugcccau uuacagugaa gaaucuggcu auguuuccag acacgguacc cauggacucc      660

cagucccugg uggagguuag agggucuugu gucaacaauu cuaaggagga agauccucca      720

aggauguacu gcaguacaga aggcgaaugg cuuguaccca uuggcaagug uuccugcaau      780

gcuggcuaug aagaaagagg uuuuaugugc caagcuuguc gaccagguuu cuacaaggca      840

uuggauggua auaugaagug ugcuaagugc ccgccucaca guucuacuca ggaagauggu      900

ucaaugaacu gcagguguga gaauaauuac uuccgggcag acaaagaccc uccauccaug      960

gcuuguaccc gaccuccauc uucaccaaga aauguuaucu cuaauauaaa cgagaccuca     1020

guuauccugg acuggaguug gccccuggac acaggaggcc ggaaagaugu uaccuucaac     1080

aucauaugua aaaaaugugg guggaauaua aaacagugug agccaugcag cccaaauguc     1140

cgcuuccucc cucgacaguu uggacucacc aacaccacgg ugacagugac agaccuucug     1200

gcacauacua acuacaccuu ugagauugau gccguuaaug gggugucaga gcugagcucc     1260

ccaccaagac aguuugcugc ggucagcauc acaacuaauc aggcugcucc aucaccuguc     1320

cugacgauua agaaagaucg gaccuccaga aauagcaucu cuuuguccug gcaagaaccu     1380

gaacauccua augggaucau auuggacuac gaggucaaau acuaugaaaa gcaggaacaa     1440

gaaacaaguu auaccauucu gagggcaaga ggcacaaaug uuaccaucag uagccucaag     1500

ccugacacua uauacguauu ccaaauccga gcccgaacag ccgcuggaua ugggacgaac     1560

agccgcaagu uugaguuuga aacuagucca gacucuuucu ccaucucugg ugaaaguagc     1620

caagugguca ugaucgccau uucagcggca guagcaauua uucuccucac uguugucauc     1680

uauguuuuga uugggagguu cuguggcuau aagucaaaac auggggcaga ugaaaaaaga     1740

cuucauuuug gcaaugggca uuuaaaacuu ccaggucuca ggacuuaugu ugacccacau     1800

acauaugaag acccuaccca aacuguucau gaguuugcca aggaauugga ugccaccaac     1860

auauccauug auaaaguugu uggagcaggu gaauuuggag aggugugcag uggucgcuua     1920

aaacuuccuu caaaaaaaga gauuucagug gccauuaaga cccugaaagu uggcuacaca     1980

gaaaagcaga ggagagacuu ccugggagaa gcaagcauua ugggacaguu ugaccacccc     2040

aauaucauuc gacuggaagg aguuguuacc aaaaguaagc caguuaugau ugucacagaa     2100

uacauggaga augguuccuu ggauaguuuc cuacguaaac acgaugccca guuuacuguc     2160

auucagcuag uggggaugcu ucgagggaua gcaucuggca ugaaguaccu gucagacaug     2220

ggcuauguuc accgagaccu cgcugcucgg aacaucuuga ucaacaguaa cuuggugugu     2280

aagguuucug auuucggacu uucgcguguc cuggaggaug acccagaagc ugcuuauaca     2340

acaagaggag ggaagauccc aaucaggugg acaucaccag aagcuauagc cuaccgcaag     2400

uucacgucag ccagcgaugu auggaguuau gggauuguuc ucugggaggu gaugucuuau     2460

ggagagagac cauacuggga gauguccaau caggauguaa uuaaagcugu agaugagggc     2520

uaucgacugc caccccccau ggacugccca gcugccuugu aucagcugau gcuggacugc     2580

uggcagaaag acaggaacaa cagacccaag uuugagcaga uuguuaguau ucuggacaag     2640

cuuauccgga aucccggcag ccugaagauc aucaccagug cagccgcaag gccaucaaac     2700

cuucuucugg accaaagcaa uguggauauc acuaccuucc gcacaacagg ugacuggcuu     2760

aauggugucu ggacagcaca cugcaaggaa aucuucacgg guguggagua caguucuugu     2820

gacacaauag ccaagauuuc cacagaugac augaaaaagg uuggugucac cgugguuggg     2880

ccacagaaga agaucaucag uagcauuaaa gcucuagaaa cgcaaucaaa gaauggccca     2940

guucccgugu aa                                                         2952


<210>  1443
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EphA3__Homo_sapiens__AAH63282

<400>  1443
auggacugcc agcugagcau ccuccugcug cucuccugca gcgugcugga cuccuucggc       60

gagcugaucc cccagccgag caacgagguc aaccuccugg acuccaagac cauccagggg      120

gagcugggcu ggaucagcua ccccucccac gggugggagg agaucagcgg cguggacgag      180

cacuacaccc ccauccgcac guaccaggug ugcaacguca uggaccacuc ccagaacaac      240

uggcuccgga ccaacugggu gccccgcaac agcgcccaga agaucuacgu ggagcugaag      300

uucacccugc gggacugcaa cuccaucccg cucguccugg ggaccugcaa ggagacguuc      360

aaccuguacu acauggagag cgacgacgac cacggcguga aguuccgcga gcaccaguuc      420

accaagaucg acaccaucgc cgcggacgag uccuucaccc agauggaccu cggcgaccgg      480

auccugaagc ugaacacgga gauccgcgag guggggcccg ucaacaagaa gggcuucuac      540

cucgccuucc aggacguggg ggccugcgug gcccugguca gcgugcgggu guacuucaag      600

aagugccccu ucaccgucaa gaaccuggcc auguuccccg acaccgugcc gauggacucc      660

cagagccucg uggagguccg cggcuccugc gugaacaaca gcaaggagga ggacccgccc      720

cggauguacu gcuccaccga gggggagugg cuggugccca ucggcaagug cagcugcaac      780

gcgggcuacg aggagcgcgg guucaugugc caggccugcc ggcccggcuu cuacaaggcc      840

cuggacggga acaugaagug cgccaagugc ccgccccaca gcuccacgca ggaggacggc      900

agcaugaacu gccgcugcga gaacaacuac uuccgggcgg acaaggaccc gcccuccaug      960

gccugcaccc gcccgcccag cagcccccgg aacgucaucu ccaacaucaa cgagaccucc     1020

gugauccucg acuggagcug gccccuggac accggcgggc gcaaggacgu gacguucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcuc ccccaacguc     1140

cgguuccugc cccgccaguu cgggcucacc aacaccaccg ugacggucac cgaccugcug     1200

gcccacacca acuacaccuu cgagaucgac gccgugaacg gcgugagcga gcucuccagc     1260

ccgccccggc aguucgccgc ggucuccauc acgaccaacc aggccgcccc cagccccgug     1320

cugaccauca agaaggaccg caccucccgg aacagcaucu cccugagcug gcaggagccc     1380

gagcacccca acgggaucau ccucgacuac gaggugaagu acuacgagaa gcaggagcag     1440

gagacguccu acaccauccu gcgcgcccgc ggcaccaacg ucaccaucag cagccugaag     1500

cccgacacga ucuacguguu ccagauccgg gcccgcaccg cggccggcua cgggaccaac     1560

ucccggaagu ucgaguucga gaccagcccg gacuccuuca gcaucuccgg cgagagcucc     1620

caggugguca ugaucgccau cagcgccgcc guggcgauca uccuccugac gguggucauc     1680

uacgugcuga ucgggcgcuu cugcggcuac aaguccaagc acggggccga cgagaagcgg     1740

cuccacuucg gcaacggcca ccugaagcug cccgggcucc gcaccuacgu ggacccccac     1800

accuacgagg accccaccca gaccguccac gaguucgcca aggagcugga cgccacgaac     1860

aucagcaucg acaagguggu gggcgccggg gaguucggcg aggucugcuc cgggcggcug     1920

aagcucccga gcaagaagga gaucuccgug gcgaucaaga cccugaaggu gggcuacacc     1980

gagaagcagc gccgggacuu ccugggcgag gccagcauca uggggcaguu cgaccacccc     2040

aacaucaucc gccucgaggg cgucgugacc aaguccaagc ccgugaugau cgucacggag     2100

uacauggaga acgggagccu ggacuccuuc cugcggaagc acgacgccca guucaccgug     2160

auccagcugg ugggcaugcu ccgcggcauc gccagcggga ugaaguaccu gagcgacaug     2220

ggcuacgucc accgggaccu ggcggcccgc aacauccuca ucaacuccaa ccuggugugc     2280

aaggugagcg acuucgggcu gucccggguc cucgaggacg accccgaggc cgccuacacc     2340

acccgcggcg ggaagauccc gauccggugg acgagccccg aggccaucgc guaccgcaag     2400

uucaccuccg ccagcgacgu gugguccuac ggcaucgugc ugugggaggu caugagcuac     2460

ggcgagcggc ccuacuggga gauguccaac caggacguga ucaaggccgu ggacgagggg     2520

uaccgccugc ccccgcccau ggacugcccc gccgcccucu accagcugau gcuggacugc     2580

uggcagaagg accgcaacaa ccggcccaag uucgagcaga ucgucagcau ccucgacaag     2640

cugauccgca acccgggcuc ccugaagauc aucaccagcg cggccgcccg gcccuccaac     2700

cuccugcugg accagagcaa cguggacauc accacguucc gcaccaccgg ggacuggcuc     2760

aacggcgugu ggaccgccca cugcaaggag aucuucacgg gggucgagua cuccagcugc     2820

gacaccaucg ccaagaucuc caccgacgac augaagaagg ugggcgugac cgucgugggc     2880

ccccagaaga agaucaucag cuccaucaag gcgcuggaga cgcagagcaa gaacgggccc     2940

gugccggucu ga                                                         2952


<210>  1444
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EphA3__Homo_sapiens__AAH63282

<400>  1444
auggacugcc agcucuccau ccuccuccuc cucuccugcu ccguccucga cuccuucggc       60

gagcucaucc cccagcccuc caacgagguc aaccuccucg acuccaagac cauccagggc      120

gagcucggcu ggaucuccua ccccucccac ggcugggagg agaucuccgg cgucgacgag      180

cacuacaccc ccauccgcac cuaccagguc ugcaacguca uggaccacuc ccagaacaac      240

uggcuccgca ccaacugggu cccccgcaac uccgcccaga agaucuacgu cgagcucaag      300

uucacccucc gcgacugcaa cuccaucccc cucguccucg gcaccugcaa ggagaccuuc      360

aaccucuacu acauggaguc cgacgacgac cacggcguca aguuccgcga gcaccaguuc      420

accaagaucg acaccaucgc cgccgacgag uccuucaccc agauggaccu cggcgaccgc      480

auccucaagc ucaacaccga gauccgcgag gucggccccg ucaacaagaa gggcuucuac      540

cucgccuucc aggacgucgg cgccugcguc gcccucgucu ccguccgcgu cuacuucaag      600

aagugccccu ucaccgucaa gaaccucgcc auguuccccg acaccguccc cauggacucc      660

cagucccucg ucgagguccg cggcuccugc gucaacaacu ccaaggagga ggaccccccc      720

cgcauguacu gcuccaccga gggcgagugg cucgucccca ucggcaagug cuccugcaac      780

gccggcuacg aggagcgcgg cuucaugugc caggccugcc gccccggcuu cuacaaggcc      840

cucgacggca acaugaagug cgccaagugc cccccccacu ccuccaccca ggaggacggc      900

uccaugaacu gccgcugcga gaacaacuac uuccgcgccg acaaggaccc ccccuccaug      960

gccugcaccc gcccccccuc cuccccccgc aacgucaucu ccaacaucaa cgagaccucc     1020

gucauccucg acugguccug gccccucgac accggcggcc gcaaggacgu caccuucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcuc ccccaacguc     1140

cgcuuccucc cccgccaguu cggccucacc aacaccaccg ucaccgucac cgaccuccuc     1200

gcccacacca acuacaccuu cgagaucgac gccgucaacg gcgucuccga gcucuccucc     1260

cccccccgcc aguucgccgc cgucuccauc accaccaacc aggccgcccc cucccccguc     1320

cucaccauca agaaggaccg caccucccgc aacuccaucu cccucuccug gcaggagccc     1380

gagcacccca acggcaucau ccucgacuac gaggucaagu acuacgagaa gcaggagcag     1440

gagaccuccu acaccauccu ccgcgcccgc ggcaccaacg ucaccaucuc cucccucaag     1500

cccgacacca ucuacgucuu ccagauccgc gcccgcaccg ccgccggcua cggcaccaac     1560

ucccgcaagu ucgaguucga gaccuccccc gacuccuucu ccaucuccgg cgaguccucc     1620

caggucguca ugaucgccau cuccgccgcc gucgccauca uccuccucac cgucgucauc     1680

uacguccuca ucggccgcuu cugcggcuac aaguccaagc acggcgccga cgagaagcgc     1740

cuccacuucg gcaacggcca ccucaagcuc cccggccucc gcaccuacgu cgacccccac     1800

accuacgagg accccaccca gaccguccac gaguucgcca aggagcucga cgccaccaac     1860

aucuccaucg acaaggucgu cggcgccggc gaguucggcg aggucugcuc cggccgccuc     1920

aagcuccccu ccaagaagga gaucuccguc gccaucaaga cccucaaggu cggcuacacc     1980

gagaagcagc gccgcgacuu ccucggcgag gccuccauca ugggccaguu cgaccacccc     2040

aacaucaucc gccucgaggg cgucgucacc aaguccaagc ccgucaugau cgucaccgag     2100

uacauggaga acggcucccu cgacuccuuc cuccgcaagc acgacgccca guucaccguc     2160

auccagcucg ucggcaugcu ccgcggcauc gccuccggca ugaaguaccu cuccgacaug     2220

ggcuacgucc accgcgaccu cgccgcccgc aacauccuca ucaacuccaa ccucgucugc     2280

aaggucuccg acuucggccu cucccgcguc cucgaggacg accccgaggc cgccuacacc     2340

acccgcggcg gcaagauccc cauccgcugg accucccccg aggccaucgc cuaccgcaag     2400

uucaccuccg ccuccgacgu cugguccuac ggcaucgucc ucugggaggu cauguccuac     2460

ggcgagcgcc ccuacuggga gauguccaac caggacguca ucaaggccgu cgacgagggc     2520

uaccgccucc ccccccccau ggacugcccc gccgcccucu accagcucau gcucgacugc     2580

uggcagaagg accgcaacaa ccgccccaag uucgagcaga ucgucuccau ccucgacaag     2640

cucauccgca accccggcuc ccucaagauc aucaccuccg ccgccgcccg ccccuccaac     2700

cuccuccucg accaguccaa cgucgacauc accaccuucc gcaccaccgg cgacuggcuc     2760

aacggcgucu ggaccgccca cugcaaggag aucuucaccg gcgucgagua cuccuccugc     2820

gacaccaucg ccaagaucuc caccgacgac augaagaagg ucggcgucac cgucgucggc     2880

ccccagaaga agaucaucuc cuccaucaag gcccucgaga cccaguccaa gaacggcccc     2940

guccccgucu ga                                                         2952


<210>  1445
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EphA3__Homo_sapiens__AAH63282

<400>  1445
auggacugcc agcugagcau ccuccuucug uuguccuguu cuguguuaga uucauucggc       60

gagcugauuc cccaaccuag uaacgaaguc aaucuacucg acagcaagac cauacagggg      120

gagcugggau ggaucuccua cccaucucac gguugggaag agauuucggg cguugaugaa      180

cauuauacac cgaucagaac uuaccaggug ugcaacguaa uggaccacuc acagaauaac      240

uggcuuagga cgaauugggu gccccggaac agcgcccaga aaauuuaugu cgagcugaag      300

uuuaccuugc gcgauuguaa uaguaucccu cucgugcugg ggacaugcaa agagacuuuc      360

aaccuguacu auauggaauc cgacgaugac cauggaguua aguuucgaga gcaccaauuc      420

accaaaauag auacaaucgc ugcagacgaa ucuuuuaccc agauggaucu cggcgaccgu      480

auuuuaaagc ugaauacuga gaucagagag guggguccag ucaacaagaa aggguucuac      540

cuugccuuuc aggauguggg agcgugugua gcuuugguua gcgugagggu cuauuucaag      600

aaaugccccu uuacagugaa gaaucuggcc auguucccug acaccgugcc aauggacucc      660

caaagucuag ucgaaguucg gggcucaugu gugaacaaua gcaaagagga agaucccccu      720

cgcauguacu gcucuacgga gggcgaaugg cucguaccaa uugggaagug uuccugcaac      780

gcaggauacg aggagagagg uuuuaugugu caggccugca ggccgggcuu cuauaaggcu      840

cuggacggga auaugaaaug cgcaaagugu cccccucauu caagcacuca ggaagaugga      900

aguaugaacu gccgguguga gaacaauuac uuucgcgccg acaaagaucc acccucuaug      960

gcuugcaccc gaccuccauc cagccccaga aacgugaucu cgaauauaaa cgaaacaucu     1020

gucauucuug acugguccug gccgcuggau acuggcggua ggaaggacgu gaccuucaau     1080

aucauuugua aaaagugcgg guggaacauc aaacagugug agccuugcuc acccaauguu     1140

cgguucuugc cacgucaauu uggacucaca aacaccacgg ugacugucac agaucuguua     1200

gcccacacca auuauacuuu cgaaaucgac gcggugaacg gcguaaguga gcugagcucc     1260

ccuccccgcc aguuugcagc cguuucuauu acaaccaauc aggcugcccc aagccccgug     1320

cucacgauaa agaaggauag aaccucaagg aacaguaucu cccuuagcug gcaagagccu     1380

gaacacccaa auggcauuau ccuggacuac gaggucaaau auuacgaaaa gcaggagcag     1440

gaaacaucuu auacuauauu gcgggcacga gggaccaacg ugacaauuuc aagucuaaaa     1500

ccggacacua ucuacgucuu ccagauccgc gcuagaaccg ccgcgggaua cgguacaaau     1560

agcaggaagu uugaguucga gaccuccccc gauucuuuuu cgauuagcgg cgaauccuca     1620

caagugguua ugaucgccau uagugcagcu guggccauaa uccugcucac uguagucauu     1680

uaugugcuga ucgggcgguu cuguggauac aaaucuaagc auggcgcuga cgagaagcgc     1740

cuucacuuug guaacgggca ucugaaauug ccuggccuca gaacguaugu ugauccacac     1800

acauacgaag accccaccca gacugugcac gaguucgcca aggagcugga ugcaaccaac     1860

aucagcauug acaaagucgu gggagccggc gaauuugggg agguaugcuc cggaagguua     1920

aagcugccua gcaaaaagga aauaucagug gcuaucaaga cacuaaaagu ugguuauacc     1980

gagaagcagc gucgggauuu ccucggcgaa gcgucuauua uggggcaguu ugaccaucca     2040

aauaucauuc gacuggaggg agucgugacu aaauccaagc ccgugaugau cgucacagag     2100

uacauggaaa acggcagucu ugauagcuuc uugagaaaac acgacgcaca auucacgguu     2160

auacagcugg uggguaugcu cagggggauc gccucuggca ugaaguaucu guccgauaug     2220

ggauacgugc aucgcgaccu ugcugcccgg aauauucuga ucaacucaaa uuugguaugu     2280

aaggucagug auuuuggccu cagcagagug cuggaggacg acccggaagc agccuacacc     2340

acucgcgggg gaaaaauucc uaucaggugg acaucgccag aggcuauagc cuaucgaaag     2400

uucaccuccg caucugaugu uuggagcuac gguauugugu uaugggaagu caugucauau     2460

ggcgagcggc ccuacuggga gaugaguaac caggacguga ucaaagcggu ugaugaaggg     2520

uaucgucugc cucccccaau ggacugcccu gcugcccuau accagcucau gcuggauugc     2580

uggcaaaagg acagaaauaa caggcccaaa uuugagcaga uuguguccau ccuugauaag     2640

uugauacgca auccaggauc ucugaaaauc auuacaagcg cagccgcucg gccguccaac     2700

cuccuguuag accagucaaa uguagauauc acuaccuuca gaacgaccgg cgacuggcug     2760

aacggugucu ggacagccca cuguaaggaa auuuuuacug ggguggagua uagcaguugc     2820

gauaccaucg caaagauauc uacagacgau augaaaaagg ugggcgucac uguuguggga     2880

ccucagaaaa agauuaucuc cagcaucaaa gcucuugaaa cccaaucgaa gaauggcccc     2940

guaccagugu ga                                                         2952


<210>  1446
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EphA3__Homo_sapiens__AAH63282

<400>  1446
auggacugcc agcugagcau ccugcugcug cugagcugca gcgugcugga cagcuucggc       60

gagcugaucc cccagcccag caacgaggug aaccugcugg acagcaagac cauccagggc      120

gagcugggcu ggaucagcua ccccagccac ggcugggagg agaucagcgg cguggacgag      180

cacuacaccc ccaucagaac cuaccaggug ugcaacguga uggaccacag ccagaacaac      240

uggcugagaa ccaacugggu gcccagaaac agcgcccaga agaucuacgu ggagcugaag      300

uucacccuga gagacugcaa cagcaucccc cuggugcugg gcaccugcaa ggagaccuuc      360

aaccuguacu acauggagag cgacgacgac cacggcguga aguucagaga gcaccaguuc      420

accaagaucg acaccaucgc cgccgacgag agcuucaccc agauggaccu gggcgacaga      480

auccugaagc ugaacaccga gaucagagag gugggccccg ugaacaagaa gggcuucuac      540

cuggccuucc aggacguggg cgccugcgug gcccugguga gcgugagagu guacuucaag      600

aagugccccu ucaccgugaa gaaccuggcc auguuccccg acaccgugcc cauggacagc      660

cagagccugg uggaggugag aggcagcugc gugaacaaca gcaaggagga ggaccccccc      720

agaauguacu gcagcaccga gggcgagugg cuggugccca ucggcaagug cagcugcaac      780

gccggcuacg aggagagagg cuucaugugc caggccugca gacccggcuu cuacaaggcc      840

cuggacggca acaugaagug cgccaagugc cccccccaca gcagcaccca ggaggacggc      900

agcaugaacu gcagaugcga gaacaacuac uucagagccg acaaggaccc ccccagcaug      960

gccugcacca gaccccccag cagccccaga aacgugauca gcaacaucaa cgagaccagc     1020

gugauccugg acuggagcug gccccuggac accggcggca gaaaggacgu gaccuucaac     1080

aucaucugca agaagugcgg cuggaacauc aagcagugcg agcccugcag ccccaacgug     1140

agauuccugc ccagacaguu cggccugacc aacaccaccg ugaccgugac cgaccugcug     1200

gcccacacca acuacaccuu cgagaucgac gccgugaacg gcgugagcga gcugagcagc     1260

ccccccagac aguucgccgc cgugagcauc accaccaacc aggccgcccc cagccccgug     1320

cugaccauca agaaggacag aaccagcaga aacagcauca gccugagcug gcaggagccc     1380

gagcacccca acggcaucau ccuggacuac gaggugaagu acuacgagaa gcaggagcag     1440

gagaccagcu acaccauccu gagagccaga ggcaccaacg ugaccaucag cagccugaag     1500

cccgacacca ucuacguguu ccagaucaga gccagaaccg ccgccggcua cggcaccaac     1560

agcagaaagu ucgaguucga gaccagcccc gacagcuuca gcaucagcgg cgagagcagc     1620

caggugguga ugaucgccau cagcgccgcc guggccauca uccugcugac cguggugauc     1680

uacgugcuga ucggcagauu cugcggcuac aagagcaagc acggcgccga cgagaagaga     1740

cugcacuucg gcaacggcca ccugaagcug cccggccuga gaaccuacgu ggacccccac     1800

accuacgagg accccaccca gaccgugcac gaguucgcca aggagcugga cgccaccaac     1860

aucagcaucg acaagguggu gggcgccggc gaguucggcg aggugugcag cggcagacug     1920

aagcugccca gcaagaagga gaucagcgug gccaucaaga cccugaaggu gggcuacacc     1980

gagaagcaga gaagagacuu ccugggcgag gccagcauca ugggccaguu cgaccacccc     2040

aacaucauca gacuggaggg cguggugacc aagagcaagc ccgugaugau cgugaccgag     2100

uacauggaga acggcagccu ggacagcuuc cugagaaagc acgacgccca guucaccgug     2160

auccagcugg ugggcaugcu gagaggcauc gccagcggca ugaaguaccu gagcgacaug     2220

ggcuacgugc acagagaccu ggccgccaga aacauccuga ucaacagcaa ccuggugugc     2280

aaggugagcg acuucggccu gagcagagug cuggaggacg accccgaggc cgccuacacc     2340

accagaggcg gcaagauccc caucagaugg accagccccg aggccaucgc cuacagaaag     2400

uucaccagcg ccagcgacgu guggagcuac ggcaucgugc ugugggaggu gaugagcuac     2460

ggcgagagac ccuacuggga gaugagcaac caggacguga ucaaggccgu ggacgagggc     2520

uacagacugc ccccccccau ggacugcccc gccgcccugu accagcugau gcuggacugc     2580

uggcagaagg acagaaacaa cagacccaag uucgagcaga ucgugagcau ccuggacaag     2640

cugaucagaa accccggcag ccugaagauc aucaccagcg ccgccgccag acccagcaac     2700

cugcugcugg accagagcaa cguggacauc accaccuuca gaaccaccgg cgacuggcug     2760

aacggcgugu ggaccgccca cugcaaggag aucuucaccg gcguggagua cagcagcugc     2820

gacaccaucg ccaagaucag caccgacgac augaagaagg ugggcgugac cguggugggc     2880

ccccagaaga agaucaucag cagcaucaag gcccuggaga cccagagcaa gaacggcccc     2940

gugcccgugu ga                                                         2952


<210>  1447
<211>  2952
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EphA3__Homo_sapiens__AAH63282

<400>  1447
auggacugcc agcugagcau ccuccugcuu cuguccuguu cugugcucga uagcuucggc       60

gagcugauuc cccaaccuuc caacgaaguc aaucuucugg acucuaagac cauccagggg      120

gagcucggau ggauuagcua cccgucccac ggcugggaag agaucucugg gguugaugaa      180

cauuauacac ccauuagaac guaccaggug ugcaacguga uggaccacag ccagaauaac      240

uggcugcgga ccaauugggu cccucgcaac uccgcccaaa agaucuaugu ggagcugaag      300

uuuacacuca gagauuguaa uagcaucccc cugguucuug gaaccugcaa agagacauuc      360

aaccuguacu auauggaauc ugacgaugac cauggcguga aguuucggga gcaccaguuc      420

accaaaauug auacaaucgc ugccgacgaa uccuuuaccc agauggaucu cggggaccgc      480

auucugaaac uuaauacgga gaucagagag gucggaccug ugaacaagaa aggcuucuac      540

cuggcguuuc aggauguugg cgcuugugug gcccucguca gcgugcgggu guauuucaag      600

aaaugccccu uuaccgucaa gaaucuggcc auguucccug acacaguucc gauggacucu      660

caaucccugg uggaagugcg cgggagcugu gucaacaauu cuaaagagga agaucccccu      720

agaauguacu gcuccaccga gggagaaugg cucgugccca uuggcaagug uagcugcaac      780

gcuggguacg aggagcgggg auuuaugugu caggccugcc gcccuggcuu cuauaaggcu      840

cuggacggga auaugaaaug cgccaagugu cccccgcauu ccucuacaca ggaagaugga      900

agcaugaacu gcagauguga gaacaauuac uuucgggcgg acaaagaucc ucccuccaug      960

gccugcaccc gcccucccag cucucccaga aacguuaucu ccaauauuaa cgaaacgagc     1020

gugauccuug acuggucuug gccucuggau acaggcggcc ggaaggacgu caccuucaau     1080

aucauuugua aaaagugcgg guggaacauc aaacagugug agccgugcag ccccaaugug     1140

cgcuuccucc cuagacaauu uggacugaca aacaccaccg uuacagugac ggaucuucug     1200

gcucacacca auuauacauu cgaaauugac gccgucaacg gcguguccga gcucucuucu     1260

cccccucggc aguuugcugc cgucuccauc accacaaauc aggcggcccc cagcccggug     1320

cugaccauua agaaggauag aacgucucgc aacuccauca gccugucuug gcaagagccu     1380

gaacacccca augggaucau ucucgacuac gagguuaaau auuacgaaaa gcaggagcag     1440

gaaacauccu auaccauccu gcgggcuaga ggaaccaacg ugacaauuag cucccuuaaa     1500

ccugacacca ucuacgucuu ccagauucgc gcccggacag cugccggcua cgggacgaau     1560

agcagaaagu uugaguucga gaccagcccc gauuccuuuu cuaucagcgg agaauccagc     1620

caagugguua ugaucgccau uucugcugcg guggccauca uucugcucac agucgugauc     1680

uaugugcuga uuggccgcuu cuguggcuac aaauccaagc auggggcuga cgagaagcgg     1740

cuucacuuug gaaacggcca ucugaaacuc ccugggcuga gaaccuaugu ugauccccac     1800

acauacgaag acccgaccca gacgguccac gaguucgcca aggagcugga ugccaccaac     1860

aucagcauug acaaaguggu gggagcuggc gaauuugggg aggucugcuc uggccgccuc     1920

aagcugccuu ccaaaaagga aaucagcgug gccaucaaga cacuuaaagu uggauauacc     1980

gagaagcagc ggagagauuu ccugggcgaa gcgucuauua uggggcaguu ugaccauccc     2040

aauaucauuc gccucgaggg aguggucaca aaaagcaagc ccgugaugau cguuaccgag     2100

uacauggaaa acggcucccu ggauagcuuc cugcggaaac acgacgcuca auucacggug     2160

auucagcuug ucgggaugcu cagaggaauc gccucuggca ugaaguaucu guccgauaug     2220

ggguacgugc aucgggaccu ggccgcucgc aauauccuca uuaacagcaa ucugguuugu     2280

aagguguccg auuuuggccu uucuagaguc cuggaggacg acccugaagc cgcuuacaca     2340

acccggggag gcaaaauccc gauuagaugg acaagccccg aggccaucgc guaucgcaag     2400

uucaccuccg ccucugaugu guggagcuac gggauugugc ucugggaagu cauguccuau     2460

ggagagcggc cuuacuggga gaugucuaac caggacguua ucaaagcugu ggaugaaggc     2520

uauagacugc ccccucccau ggacugcccu gccgcucugu accagcuuau gcucgauugc     2580

uggcaaaagg accgcaauaa cagacccaaa uuugagcaga ucgugagcau ucuggauaag     2640

cugauccgga auccgggguc ccucaaaauu aucaccagcg ccgcggcccg cccuucuaac     2700

cugcuucugg accaguccaa ugucgauauu acaacguuca gaaccacagg agacuggcuc     2760

aacggcgugu ggaccgcuca cuguaaggaa aucuuuacag ggguugagua uagcucuugc     2820

gauaccaucg ccaagauuuc cacggacgau augaaaaagg ugggcgucac agugguugga     2880

ccccagaaaa agaucauuag cucuaucaaa gcucuggaaa cccaauccaa gaauggcccu     2940

gugcccgucu ga                                                         2952


<210>  1448
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ErbB3__Homo_sapiens__B3KWG5

<400>  1448

Met Pro Met Ser Thr Ile Leu Pro Val Thr Ser Pro Cys Leu Pro Ala 
1               5                   10                  15      


Thr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            20                  25                  30          


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        35                  40                  45              


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    50                  55                  60                  


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                85                  90                  95      


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            100                 105                 110         


His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu 
        115                 120                 125             


Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr 
    130                 135                 140                 


Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg 
145                 150                 155                 160 


Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro 
                165                 170                 175     


Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser 
            180                 185                 190         


Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro 
        195                 200                 205             


Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser 
    210                 215                 220                 


Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg 
225                 230                 235                 240 


Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg 
                245                 250                 255     


His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu 
            260                 265                 270         


Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly 
        275                 280                 285             


Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser 
    290                 295                 300                 


Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met 
305                 310                 315                 320 


Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser 
                325                 330                 335     


Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser 
            340                 345                 350         


Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile 
        355                 360                 365             


Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn 
    370                 375                 380                 


Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly 
385                 390                 395                 400 


Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln 
                405                 410                 415     


Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr 
            420                 425                 430         


Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr 
        435                 440                 445             


Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr 
    450                 455                 460         


<210>  1449
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ErbB3__Homo_sapiens__BAG54127

<400>  1449
augcccaugu cuacuauuuu gccagugacu aguccauguc uuccugcaac aggugugaca       60

guuugggagu ugaugaccuu cggggcagag cccuaugcag ggcuacgauu ggcugaagua      120

ccagaccugc uagagaaggg ggagcgguug gcacagcccc agaucugcac aauugauguc      180

uacaugguga uggucaagug uuggaugauu gaugagaaca uucgcccaac cuuuaaagaa      240

cuagccaaug aguucaccag gauggcccga gacccaccac gguaucuggu cauaaagaga      300

gagagugggc cuggaauagc cccugggcca gagccccaug gucugacaaa caagaagcua      360

gaggaaguag agcuggagcc agaacuagac cuagaccuag acuuggaagc agaggaggac      420

aaccuggcaa ccaccacacu gggcuccgcc cucagccuac caguuggaac acuuaaucgg      480

ccacguggga gccagagccu uuuaagucca ucaucuggau acaugcccau gaaccagggu      540

aaucuugggg agucuugcca ggagucugca guuucuggga gcagugaacg gugcccccgu      600

ccagucucuc uacacccaau gccacgggga ugccuggcau cagagucauc agaggggcau      660

guaacaggcu cugaggcuga gcuccaggag aaagugucaa uguguagaag ccggagcagg      720

agccggagcc cacggccacg cggagauagc gccuaccauu cccagcgcca cagucugcug      780

acuccuguua ccccacucuc cccacccggg uuagaggaag aggaugucaa cgguuauguc      840

augccagaua cacaccucaa agguacuccc uccucccggg aaggcacccu uucuucagug      900

ggucucaguu cuguccuggg uacugaagaa gaagaugaag augaggagua ugaauacaug      960

aaccggagga gaaggcacag uccaccucau cccccuaggc caaguucccu ugaggagcug     1020

gguuaugagu acauggaugu ggggucagac cucagugccu cucugggcag cacacagagu     1080

ugcccacucc acccuguacc caucaugccc acugcaggca caacuccaga ugaagacuau     1140

gaauauauga aucggcaacg agauggaggu gguccugggg gugauuaugc agccaugggg     1200

gccugcccag caucugagca aggguaugaa gagaugagag cuuuucaggg gccuggacau     1260

caggcccccc auguccauua ugcccgccua aaaacucuac guagcuuaga ggcuacagac     1320

ucugccuuug auaacccuga uuacuggcau agcaggcuuu uccccaaggc uaaugcccag     1380

agaacguaa                                                             1389


<210>  1450
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ErbB3__Homo_sapiens__BAG54127

<400>  1450
augcccauga gcaccauccu gccggugacc ucccccugcc uccccgccac gggcgucacc       60

gugugggagc ugaugaccuu cggggccgag cccuacgcgg gccugcgccu cgccgaggug      120

ccggaccugc uggagaaggg ggagcggcuc gcccagcccc agaucugcac caucgacguc      180

uacaugguga uggugaagug cuggaugauc gacgagaaca uccgccccac guucaaggag      240

cuggccaacg aguucacccg gauggcccgc gacccgcccc gguaccuggu caucaagcgc      300

gagagcggcc ccgggaucgc gcccggcccc gagccgcacg gccucaccaa caagaagcug      360

gaggaggugg agcuggagcc cgagcucgac cuggaccugg accucgaggc cgaggaggac      420

aaccuggcca ccacgacccu gggguccgcc cucagccugc ccgugggcac ccugaaccgg      480

ccccgcgggu cccagagccu ccuguccccg agcuccggcu acaugcccau gaaccagggg      540

aaccugggcg agagcugcca ggaguccgcg gucagcggcu ccagcgagcg gugcccccgc      600

cccguguccc uccacccgau gccccggggg ugccuggcca gcgaguccag cgagggccac      660

gugaccgggu ccgaggccga gcugcaggag aaggucagca ugugccgcag ccggucccgc      720

agccggagcc cccgcccccg gggcgacucc gccuaccacu cccagcgcca cagccuccug      780

acgccgguga cgccccuguc cccgcccggc cucgaggagg aggacgugaa cggguacguc      840

augcccgaca cccaccugaa gggcaccccc agcucccggg aggggacccu gagcuccgug      900

ggccucagcu ccgugcuggg gaccgaggag gaggacgagg acgaggagua cgaguacaug      960

aaccgccggc gccgccacag cccgccccac ccgccccggc ccuccagccu ggaggagcuc     1020

ggcuacgagu acauggacgu cggcuccgac cugagcgccu cccuggggag cacccagagc     1080

ugcccccucc accccgugcc caucaugccc accgcgggca cgaccccgga cgaggacuac     1140

gaguacauga accgccagcg ggacgggggc gggcccggcg gcgacuacgc cgccaugggg     1200

gccugccccg ccuccgagca gggcuacgag gagaugcgcg cguuccaggg gcccggccac     1260

caggccccgc acgugcacua cgcccggcug aagacccugc gcagccucga ggccaccgac     1320

uccgccuucg acaaccccga cuacuggcac agccggcugu uccccaaggc gaacgcccag     1380

cgcacguga                                                             1389


<210>  1451
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ErbB3__Homo_sapiens__BAG54127

<400>  1451
augcccaugu ccaccauccu ccccgucacc ucccccugcc uccccgccac cggcgucacc       60

gucugggagc ucaugaccuu cggcgccgag cccuacgccg gccuccgccu cgccgagguc      120

cccgaccucc ucgagaaggg cgagcgccuc gcccagcccc agaucugcac caucgacguc      180

uacaugguca uggucaagug cuggaugauc gacgagaaca uccgccccac cuucaaggag      240

cucgccaacg aguucacccg cauggcccgc gacccccccc gcuaccucgu caucaagcgc      300

gaguccggcc ccggcaucgc ccccggcccc gagccccacg gccucaccaa caagaagcuc      360

gaggaggucg agcucgagcc cgagcucgac cucgaccucg accucgaggc cgaggaggac      420

aaccucgcca ccaccacccu cggcuccgcc cucucccucc ccgucggcac ccucaaccgc      480

ccccgcggcu cccagucccu ccucuccccc uccuccggcu acaugcccau gaaccagggc      540

aaccucggcg aguccugcca ggaguccgcc gucuccggcu ccuccgagcg cugcccccgc      600

cccgucuccc uccaccccau gccccgcggc ugccucgccu ccgaguccuc cgagggccac      660

gucaccggcu ccgaggccga gcuccaggag aaggucucca ugugccgcuc ccgcucccgc      720

ucccgcuccc cccgcccccg cggcgacucc gccuaccacu cccagcgcca cucccuccuc      780

acccccguca ccccccucuc cccccccggc cucgaggagg aggacgucaa cggcuacguc      840

augcccgaca cccaccucaa gggcaccccc uccucccgcg agggcacccu cuccuccguc      900

ggccucuccu ccguccucgg caccgaggag gaggacgagg acgaggagua cgaguacaug      960

aaccgccgcc gccgccacuc ccccccccac cccccccgcc ccuccucccu cgaggagcuc     1020

ggcuacgagu acauggacgu cggcuccgac cucuccgccu cccucggcuc cacccagucc     1080

ugcccccucc accccguccc caucaugccc accgccggca ccacccccga cgaggacuac     1140

gaguacauga accgccagcg cgacggcggc ggccccggcg gcgacuacgc cgccaugggc     1200

gccugccccg ccuccgagca gggcuacgag gagaugcgcg ccuuccaggg ccccggccac     1260

caggcccccc acguccacua cgcccgccuc aagacccucc gcucccucga ggccaccgac     1320

uccgccuucg acaaccccga cuacuggcac ucccgccucu uccccaaggc caacgcccag     1380

cgcaccuga                                                             1389


<210>  1452
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ErbB3__Homo_sapiens__BAG54127

<400>  1452
augcccauga gcaccauccu gccugugaca uccccaugcc ucccggccac uggcgucacg       60

guuugggagc uuaugaccuu cggggcugaa cccuacgcag gacugagauu ggccgaggug      120

ccugacuuac uggaaaaggg ugagaggcua gcgcagccac aaauuuguac aauagaugua      180

uauaugguga uggucaaaug cuggaugauc gacgaaaaca uucggcccac uuuuaaggag      240

cucgcuaaug aguucacccg cauggcccga gauccuccac guuaccuggu gaucaaaaga      300

gaaucuggcc ccgggauugc accuggacca gagccgcacg gccuuacaaa caagaaacug      360

gaagagguug aguuggaacc cgagcucgac cuggaucugg accucgaagc cgaggaagau      420

aauuuagcua ccacuacacu ggguucagca cuuaguuugc cuguggggac ccugaacagg      480

ccacggggaa gccagucccu acucucuccc ucgucaggcu auaugccuau gaaucagggc      540

aaccuggggg agagcuguca ggagagugcc gucuccggau cuagcgaacg cugcccaaga      600

cccguguccc uucauccgau gccuaggggu ugucuggcuu cagagaguag cgaaggccac      660

guaacggggu cugaggccga auugcaagag aagguuucca ugugccgguc acgcagccga      720

aguagaucuc ccaggccacg gggagacucc gcguaccaua gccagcguca cucgcuccug      780

acuccuguga cccccuuauc uccacccggc cuggaggaag aggaugucaa ugguuaugug      840

augccugaca cacaucucaa ggggacucca uccucacgcg aaggaacccu uaguagcgug      900

ggccuguccu cugucuuggg cacagaggaa gaggaugagg acgaagagua cgaauauaug      960

aacagaaggc ggcgacacag cccgccccac ccuccacgcc ccucaagucu agaggagcug     1020

ggguacgaau acauggaugu uggauccgac cucagcgcau cucuggguuc aacccagagu     1080

uguccucuuc auccagugcc caucaugccg acggccggca cuacaccuga cgaggauuau     1140

gaauacauga auagacagag ggacggggga ggcccaggug gggauuaugc ugccaugggc     1200

gcaugccccg cuagcgagca aggauacgaa gagaugcggg ccuuucaggg cccugggcac     1260

caggcgcccc auguacacua ugcccgccug aaaaccuuga gaucccucga ggcaacugac     1320

ucugcuuucg auaacccaga cuacuggcac ucgaggcugu uuccuaaggc caaugcucag     1380

cguacauga                                                             1389


<210>  1453
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ErbB3__Homo_sapiens__BAG54127

<400>  1453
augcccauga gcaccauccu gcccgugacc agccccugcc ugcccgccac cggcgugacc       60

gugugggagc ugaugaccuu cggcgccgag cccuacgccg gccugagacu ggccgaggug      120

cccgaccugc uggagaaggg cgagagacug gcccagcccc agaucugcac caucgacgug      180

uacaugguga uggugaagug cuggaugauc gacgagaaca ucagacccac cuucaaggag      240

cuggccaacg aguucaccag aauggccaga gaccccccca gauaccuggu gaucaagaga      300

gagagcggcc ccggcaucgc ccccggcccc gagccccacg gccugaccaa caagaagcug      360

gaggaggugg agcuggagcc cgagcuggac cuggaccugg accuggaggc cgaggaggac      420

aaccuggcca ccaccacccu gggcagcgcc cugagccugc ccgugggcac ccugaacaga      480

cccagaggca gccagagccu gcugagcccc agcagcggcu acaugcccau gaaccagggc      540

aaccugggcg agagcugcca ggagagcgcc gugagcggca gcagcgagag augccccaga      600

cccgugagcc ugcaccccau gcccagaggc ugccuggcca gcgagagcag cgagggccac      660

gugaccggca gcgaggccga gcugcaggag aaggugagca ugugcagaag cagaagcaga      720

agcagaagcc ccagacccag aggcgacagc gccuaccaca gccagagaca cagccugcug      780

acccccguga ccccccugag cccccccggc cuggaggagg aggacgugaa cggcuacgug      840

augcccgaca cccaccugaa gggcaccccc agcagcagag agggcacccu gagcagcgug      900

ggccugagca gcgugcuggg caccgaggag gaggacgagg acgaggagua cgaguacaug      960

aacagaagaa gaagacacag ccccccccac ccccccagac ccagcagccu ggaggagcug     1020

ggcuacgagu acauggacgu gggcagcgac cugagcgcca gccugggcag cacccagagc     1080

ugcccccugc accccgugcc caucaugccc accgccggca ccacccccga cgaggacuac     1140

gaguacauga acagacagag agacggcggc ggccccggcg gcgacuacgc cgccaugggc     1200

gccugccccg ccagcgagca gggcuacgag gagaugagag ccuuccaggg ccccggccac     1260

caggcccccc acgugcacua cgccagacug aagacccuga gaagccugga ggccaccgac     1320

agcgccuucg acaaccccga cuacuggcac agcagacugu uccccaaggc caacgcccag     1380

agaaccuga                                                             1389


<210>  1454
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ErbB3__Homo_sapiens__BAG54127

<400>  1454
augcccauga gcaccauccu gccugugaca uccccgugcc uccccgccac gggcgucacc       60

guuugggagc ugaugacauu cggggcugaa ccuuacgccg gacuuagacu ggcggaggug      120

cccgaccucc uggaaaaggg cgagcggcuu gcucagccuc aaauuuguac caucgaugug      180

uauaugguca uggugaaaug cuggaugauu gacgaaaaca uccgccccac auuuaaggag      240

cuggccaaug aguucaccag aauggcccgg gauccuccgc gcuaccucgu uauuaaaaga      300

gaaucugggc ccggaaucgc uccuggcccc gagccucacg ggcugacaaa caagaaacug      360

gaagaggugg agcucgaacc cgagcuggac cuugaucugg accucgaagc cgaggaagau      420

aaucuggcua ccacgacccu uggaagcgcc cugucccucc cggucggcac acugaaccgg      480

ccucgcggcu cucagagccu gcucuccccc ucuagcgggu auaugccuau gaaucaggga      540

aaccugggcg aguccuguca ggagagcgcg gugucugggu ccagcgaaag augcccccgg      600

cccguuucuc uucauccuau gccgcgcgga ugucuggccu ccgagagcuc ugaaggccac      660

gugaccgggu ccgaggcuga acuccaagag aaggucagca ugugcagauc ccggucucgc      720

agcagauccc cucggccccg cggagacagc gccuaccauu cucagagaca cucccugcuu      780

acacccguga ccccucuguc ucccccgggc cucgaggaag aggaugugaa uggcuauguc      840

augccugaca cgcaucugaa ggggacaccc agcagccggg aaggaacccu guccucuguu      900

ggccucagcu ccgugcuggg gacagaggaa gaggaugagg acgaagagua cgaauauaug      960

aacagacgcc ggagacacag cccuccccac ccuccccgcc cgucuucccu ugaggagcug     1020

ggauacgaau acauggaugu gggcagcgac cucucugcuu cccuggggag cacccagucc     1080

uguccucuuc aucccguccc caucaugccu accgccggaa caacgccgga cgaggauuau     1140

gaauacauga aucggcagag agacggcggc gggcccggag gcgauuaugc ggccaugggg     1200

gcuugcccug ccucugagca aggauacgaa gagaugcgcg cuuuucaggg ccccgggcac     1260

caggccccuc augugcacua ugcccggcug aaaacccuca gaagccugga ggcuacagac     1320

uccgcguucg auaaccccga cuacuggcac ucucgccugu uuccuaaggc caaugcucag     1380

cggaccuga                                                             1389


<210>  1455
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ErbB3__Homo_sapiens__B4DGQ7

<400>  1455

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Gln Cys Ile Trp Met Pro Ser Leu Pro Ser Leu Ala Pro Val 
            900                 905                 910         


Ser Asn Leu Pro Phe Glu Thr Pro Ser 
        915                 920     


<210>  1456
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ErbB3__Homo_sapiens__BAG57868

<400>  1456
augagggcga acgacgcucu gcaggugcug ggcuugcuuu ucagccuggc ccggggcucc       60

gaggugggca acucucaggc aguguguccu gggacucuga auggccugag ugugaccggc      120

gaugcugaga accaauacca gacacuguac aagcucuacg agagguguga gguggugaug      180

gggaaccuug agauugugcu cacgggacac aaugccgacc ucuccuuccu gcaguggauu      240

cgagaaguga caggcuaugu ccucguggcc augaaugaau ucucuacucu accauugccc      300

aaccuccgcg uggugcgagg gacccagguc uacgauggga aguuugccau cuucgucaug      360

uugaacuaua acaccaacuc cagccacgcu cugcgccagc uccgcuugac ucagcucacc      420

gagauucugu cagggggugu uuauauugag aagaacgaua agcuuuguca cauggacaca      480

auugacugga gggacaucgu gagggaccga gaugcugaga uaguggugaa ggacaauggc      540

agaagcuguc cccccuguca ugagguuugc aaggggcgau gcuggggucc uggaucagaa      600

gacugccaga cauugaccaa gaccaucugu gcuccucagu guaaugguca cugcuuuggg      660

cccaacccca accagugcug ccaugaugag ugugccgggg gcugcucagg cccucaggac      720

acagacugcu uugccugccg gcacuucaau gacaguggag ccuguguacc ucgcugucca      780

cagccucuug ucuacaacaa gcuaacuuuc cagcuggaac ccaaucccca caccaaguau      840

caguauggag gaguuugugu agccagcugu ccccauaacu uuguggugga ucaaacaucc      900

ugugucaggg ccuguccucc ugacaagaug gaaguagaua aaaaugggcu caagaugugu      960

gagccuugug ggggacuaug ucccaaagcc ugugagggaa caggcucugg gagccgcuuc     1020

cagacugugg acucgagcaa cauugaugga uuugugaacu gcaccaagau ccugggcaac     1080

cuggacuuuc ugaucaccgg ccucaaugga gaccccuggc acaagauccc ugcccuggac     1140

ccagagaagc ucaaugucuu ccggacagua cgggagauca cagguuaccu gaacauccag     1200

uccuggccgc cccacaugca caacuucagu guuuuuucca auuugacaac cauuggaggc     1260

agaagccucu acaaccgggg cuucucauug uugaucauga agaacuugaa ugucacaucu     1320

cugggcuucc gaucccugaa ggaaauuagu gcugggcgua ucuauauaag ugccaauagg     1380

cagcucugcu accaccacuc uuugaacugg accaaggugc uucgggggcc uacggaagag     1440

cgacuagaca ucaagcauaa ucggccgcgc agagacugcg uggcagaggg caaagugugu     1500

gacccacugu gcuccucugg gggaugcugg ggcccaggcc cuggucagug cuuguccugu     1560

cgaaauuaua gccgaggagg ugucugugug acccacugca acuuucugaa uggggagccu     1620

cgagaauuug cccaugaggc cgaaugcuuc uccugccacc cggaaugcca acccauggag     1680

ggcacugcca caugcaaugg cucgggcucu gauacuugug cucaaugugc ccauuuucga     1740

gaugggcccc acugugugag cagcugcccc cauggagucc uaggugccaa gggcccaauc     1800

uacaaguacc cagauguuca gaaugaaugu cggcccugcc augagaacug cacccagggg     1860

uguaaaggac cagagcuuca agacuguuua ggacaaacac uggugcugau cggcaaaacc     1920

caucugacaa uggcuuugac agugauagca ggauugguag ugauuuucau gaugcugggc     1980

ggcacuuuuc ucuacuggcg ugggcgccgg auucagaaua aaagggcuau gaggcgauac     2040

uuggaacggg gugagagcau agagccucug gaccccagug agaaggcuaa caaagucuug     2100

gccagaaucu ucaaagagac agagcuaagg aagcuuaaag ugcuuggcuc gggugucuuu     2160

ggaacugugc acaaaggagu guggaucccu gagggugaau caaucaagau uccagucugc     2220

auuaaaguca uugaggacaa gaguggacgg cagaguuuuc aagcugugac agaucauaug     2280

cuggccauug gcagccugga ccaugcccac auuguaaggc ugcugggacu augcccaggg     2340

ucaucucugc agcuugucac ucaauauuug ccucuggguu cucugcugga ucaugugaga     2400

caacaccggg gggcacuggg gccacagcug cugcucaacu ggggaguaca aauugccaag     2460

ggaauguacu accuugagga acaugguaug gugcauagaa accuggcugc ccgaaacgug     2520

cuacucaagu cacccaguca gguucaggug gcagauuuug guguggcuga ccugcugccu     2580

ccugaugaua agcagcugcu auacagugag gccaagacuc caauuaagug gauggcccuu     2640

gagaguaucc acuuugggaa auacacacac cagagugaug ucuggagcua uggucagugc     2700

aucuggaugc ccucucuacc aucacuggcc ccaguuucaa auuuaccuuu ugagaccccc     2760

ucuuag                                                                2766


<210>  1457
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ErbB3__Homo_sapiens__BAG57868

<400>  1457
augcgcgcca acgacgcccu ccaggugcug ggccugcugu ucagccucgc gcgggggucc       60

gaggucggca acagccaggc cgugugcccc gggacccuga acggccuguc cgugaccggg      120

gacgccgaga accaguacca gacgcucuac aagcuguacg agcgcugcga ggucgugaug      180

ggcaaccugg agaucgugcu caccggccac aacgccgacc ugagcuuccu gcaguggauc      240

cgggagguca ccggguacgu gcucguggcc augaacgagu ucuccacccu gccgcugccc      300

aaccuccgcg ucgugcgggg cacccaggug uacgacggga aguucgcgau cuucgucaug      360

cugaacuaca acaccaacag cucccacgcc cugcgccagc uccggcugac ccagcugacc      420

gagauccuca gcggcggggu guacaucgag aagaacgaca agcugugcca cauggacacg      480

aucgacuggc gcgacaucgu gcgggaccgc gacgccgaga ucgucgugaa ggacaacggc      540

cgguccugcc cgcccugcca cgaggugugc aagggccgcu gcugggggcc cggcagcgag      600

gacugccaga cccugaccaa gaccaucugc gcgccccagu gcaacgggca cugcuucggc      660

cccaacccca accagugcug ccacgacgag ugcgccggcg ggugcuccgg cccgcaggac      720

acggacugcu ucgccugccg gcacuucaac gacagcgggg ccugcguccc ccgcugcccc      780

cagccccucg uguacaacaa gcugaccuuc cagcuggagc cgaaccccca caccaaguac      840

caguacggcg gggugugcgu cgccuccugc ccccacaacu ucguggugga ccagaccagc      900

ugcguccggg ccugcccgcc cgacaagaug gagguggaca agaacggccu caagaugugc      960

gagcccugcg gcgggcugug ccccaaggcg ugcgagggca cgggguccgg cagccgcuuc     1020

cagaccgucg acuccagcaa caucgacggg uucgugaacu gcaccaagau ccugggcaac     1080

cucgacuucc ugaucaccgg ccugaacggg gaccccuggc acaagauccc ggcccucgac     1140

cccgagaagc ugaacguguu ccggacgguc cgcgagauca ccggcuaccu gaacauccag     1200

uccuggccgc cccacaugca caacuucagc guguucagca accucaccac caucgggggc     1260

cggucccugu acaaccgcgg guucagccug cucaucauga agaaccugaa cgugacgucc     1320

cugggcuucc ggagccucaa ggagaucucc gccggccgca ucuacaucag cgccaaccgc     1380

cagcugugcu accaccacuc ccugaacugg accaaggucc uccgggggcc caccgaggag     1440

cgccuggaca ucaagcacaa ccggccccgc cgggacugcg uggccgaggg caaggugugc     1500

gacccccugu gcagcuccgg gggcugcugg ggccccgggc cgggccagug ccucagcugc     1560

cgcaacuacu cccgcggggg cgucugcgug acccacugca acuuccugaa cggggagccc     1620

cgggaguucg cgcacgaggc cgagugcuuc agcugccacc ccgagugcca gccgauggag     1680

ggcacggcga ccugcaacgg cuccgggagc gacacgugcg cccagugcgc ccacuuccgg     1740

gacggccccc acugcguguc cagcugcccc cacggggucc ugggcgccaa ggggcccauc     1800

uacaaguacc cggacgugca gaacgagugc cgccccugcc acgagaacug cacccagggc     1860

ugcaagggcc ccgagcugca ggacugccuc gggcagacgc uggugcugau cggcaagacc     1920

caccucacca uggcccugac cgucaucgcc gggcuggugg ugaucuucau gaugcucggc     1980

gggacguucc uguacuggcg gggccgccgg auccagaaca agcgcgccau gcggcgcuac     2040

cuggagcggg gcgaguccau cgagccccuc gacccgagcg agaaggccaa caagguccug     2100

gcgcgcaucu ucaaggagac cgagcugcgg aagcucaagg ugcugggguc cggcguguuc     2160

gggaccgucc acaagggcgu guggaucccc gagggggaga gcaucaagau ccccgugugc     2220

aucaagguca ucgaggacaa gagcggccgc caguccuucc aggccgugac cgaccacaug     2280

cuggccaucg gcagccucga ccacgcccac aucgugcgcc ugcuggggcu cugccccggc     2340

uccagccugc agcuggucac ccaguaccuc ccgcuggggu cccugcucga ccacgugcgg     2400

cagcaccgcg gcgcgcuggg cccccagcug cuccugaacu ggggcgugca gaucgccaag     2460

gggauguacu accuggagga gcacgggaug guccaccgga accucgccgc ccgcaacgug     2520

cugcucaaga gccccuccca ggugcagguc gccgacuucg gcguggcgga ccugcugccc     2580

ccggacgaca agcagcugcu cuacagcgag gccaagacgc ccaucaagug gauggcccug     2640

gaguccaucc acuucgggaa guacacccac cagagcgacg ugugguccua cggccagugc     2700

aucuggaugc ccagccugcc cucccucgcc ccggucagca accugcccuu cgagaccccc     2760

uccuga                                                                2766


<210>  1458
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ErbB3__Homo_sapiens__BAG57868

<400>  1458
augcgcgcca acgacgcccu ccagguccuc ggccuccucu ucucccucgc ccgcggcucc       60

gaggucggca acucccaggc cgucugcccc ggcacccuca acggccucuc cgucaccggc      120

gacgccgaga accaguacca gacccucuac aagcucuacg agcgcugcga ggucgucaug      180

ggcaaccucg agaucguccu caccggccac aacgccgacc ucuccuuccu ccaguggauc      240

cgcgagguca ccggcuacgu ccucgucgcc augaacgagu ucuccacccu cccccucccc      300

aaccuccgcg ucguccgcgg cacccagguc uacgacggca aguucgccau cuucgucaug      360

cucaacuaca acaccaacuc cucccacgcc cuccgccagc uccgccucac ccagcucacc      420

gagauccucu ccggcggcgu cuacaucgag aagaacgaca agcucugcca cauggacacc      480

aucgacuggc gcgacaucgu ccgcgaccgc gacgccgaga ucgucgucaa ggacaacggc      540

cgcuccugcc cccccugcca cgaggucugc aagggccgcu gcuggggccc cggcuccgag      600

gacugccaga cccucaccaa gaccaucugc gccccccagu gcaacggcca cugcuucggc      660

cccaacccca accagugcug ccacgacgag ugcgccggcg gcugcuccgg cccccaggac      720

accgacugcu ucgccugccg ccacuucaac gacuccggcg ccugcguccc ccgcugcccc      780

cagccccucg ucuacaacaa gcucaccuuc cagcucgagc ccaaccccca caccaaguac      840

caguacggcg gcgucugcgu cgccuccugc ccccacaacu ucgucgucga ccagaccucc      900

ugcguccgcg ccugcccccc cgacaagaug gaggucgaca agaacggccu caagaugugc      960

gagcccugcg gcggccucug ccccaaggcc ugcgagggca ccggcuccgg cucccgcuuc     1020

cagaccgucg acuccuccaa caucgacggc uucgucaacu gcaccaagau ccucggcaac     1080

cucgacuucc ucaucaccgg ccucaacggc gaccccuggc acaagauccc cgcccucgac     1140

cccgagaagc ucaacgucuu ccgcaccguc cgcgagauca ccggcuaccu caacauccag     1200

uccuggcccc cccacaugca caacuucucc gucuucucca accucaccac caucggcggc     1260

cgcucccucu acaaccgcgg cuucucccuc cucaucauga agaaccucaa cgucaccucc     1320

cucggcuucc gcucccucaa ggagaucucc gccggccgca ucuacaucuc cgccaaccgc     1380

cagcucugcu accaccacuc ccucaacugg accaaggucc uccgcggccc caccgaggag     1440

cgccucgaca ucaagcacaa ccgcccccgc cgcgacugcg ucgccgaggg caaggucugc     1500

gacccccucu gcuccuccgg cggcugcugg ggccccggcc ccggccagug ccucuccugc     1560

cgcaacuacu cccgcggcgg cgucugcguc acccacugca acuuccucaa cggcgagccc     1620

cgcgaguucg cccacgaggc cgagugcuuc uccugccacc ccgagugcca gcccauggag     1680

ggcaccgcca ccugcaacgg cuccggcucc gacaccugcg cccagugcgc ccacuuccgc     1740

gacggccccc acugcgucuc cuccugcccc cacggcgucc ucggcgccaa gggccccauc     1800

uacaaguacc ccgacgucca gaacgagugc cgccccugcc acgagaacug cacccagggc     1860

ugcaagggcc ccgagcucca ggacugccuc ggccagaccc ucguccucau cggcaagacc     1920

caccucacca uggcccucac cgucaucgcc ggccucgucg ucaucuucau gaugcucggc     1980

ggcaccuucc ucuacuggcg cggccgccgc auccagaaca agcgcgccau gcgccgcuac     2040

cucgagcgcg gcgaguccau cgagccccuc gaccccuccg agaaggccaa caagguccuc     2100

gcccgcaucu ucaaggagac cgagcuccgc aagcucaagg uccucggcuc cggcgucuuc     2160

ggcaccgucc acaagggcgu cuggaucccc gagggcgagu ccaucaagau ccccgucugc     2220

aucaagguca ucgaggacaa guccggccgc caguccuucc aggccgucac cgaccacaug     2280

cucgccaucg gcucccucga ccacgcccac aucguccgcc uccucggccu cugccccggc     2340

uccucccucc agcucgucac ccaguaccuc ccccucggcu cccuccucga ccacguccgc     2400

cagcaccgcg gcgcccucgg cccccagcuc cuccucaacu ggggcgucca gaucgccaag     2460

ggcauguacu accucgagga gcacggcaug guccaccgca accucgccgc ccgcaacguc     2520

cuccucaagu cccccuccca gguccagguc gccgacuucg gcgucgccga ccuccucccc     2580

cccgacgaca agcagcuccu cuacuccgag gccaagaccc ccaucaagug gauggcccuc     2640

gaguccaucc acuucggcaa guacacccac caguccgacg ucugguccua cggccagugc     2700

aucuggaugc ccucccuccc cucccucgcc cccgucucca accuccccuu cgagaccccc     2760

uccuga                                                                2766


<210>  1459
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ErbB3__Homo_sapiens__BAG57868

<400>  1459
augagagcca acgacgcucu ccaggugcug ggccuucugu ucagcuuggc aagggggucc       60

gaggucggaa auucucaagc cguuugcccc gguaccuuaa acggccuguc agugacaggg      120

gaugcggaaa aucaguacca gacucuauau aagcucuacg agcgguguga aguagugaug      180

ggaaaccugg agaucguccu uacgggccac aaugcugacc ugucguuuuu gcaguggauu      240

cgcgaaguga ccgguuaugu ucucguggcc augaacgagu ucagcacacu gccucugcca      300

aaucuccgag ucgugcgugg gacucaagua uacgauggaa aauuugcaau auucguuaug      360

uuaaacuaua auaccaacuc cucucaugcc cugagacagc uuagguugac acagcugacc      420

gagauccuau cgggcggcgu guacauugaa aagaaugaca aacucugcca cauggauacu      480

aucgacuggc gggauauugu ccgcgacaga gaugcugaga ucguggugaa ggacaacggg      540

aggucauguc cgcccugcca ugaagucugu aaaggacggu gcuggggucc uggcagcgag      600

gauugucaga cacugaccaa gacgauaugc gcaccacaau guaaugggca cugcuuugga      660

cccaacccua aucaguguug ccaugacgag ugcgccggcg guuguagugg gccacaggau      720

acugacugcu ucgcuugucg ccacuuuaac gacuccggag ccugcguucc ccgauguccu      780

cagccacuug uguauaacaa gcugaccuuc caauuggaac cgaaucccca cacaaaauac      840

caguacggcg gcguaugcgu ggcgucuugu ccucauaacu uugucgugga ucagacuagc      900

ugcguuagag cauguccacc cgacaagaug gagguggaua aaaaugggcu caagaugugc      960

gaaccuugug gaggucugug cccaaaagcc ugcgagggca ccggguccgg aucaagguuc     1020

caaacagucg acaguagcaa caucgauggc uuugugaauu guaccaagau uuuagguaac     1080

cuggacuucc ucaucacggg gcuuaauggc gaucccuggc acaagauucc ggcucuggac     1140

ccugaaaaau ugaacguauu ucggacuguu cgugagauca caggauaucu aaauauacag     1200

ucuuggcccc cacauaugca caacuucucc guguucucaa aucugaccac uauuggcggg     1260

cgcagccucu acaacagagg auuuagucug cuuaucauga agaaucugaa cgucacaucu     1320

uuggguuuca ggucccucaa agagauuagc gccggccgga ucuauaucuc ggcaaaucga     1380

cagcugugcu accaccauuc uuuaaacugg accaaggugc ugcgcgggcc uacggaagag     1440

agacuagaua uuaaacacaa caggccccgg cgcgacugug ucgcugaagg aaaggugugc     1500

gauccacucu guuccucagg cgguugcugg gggcccggcc cuggacagug ucugaguugc     1560

agaaauuaua gcaggggcgg gguuugugug acccauugca acuuucuuaa uggagagcca     1620

cgugaguucg cccacgaggc ggaguguuuu uccugccauc cggaaugcca acccauggag     1680

gguacagcca cuuguaacgg cucugggagc gauaccugcg cacagugugc ucacuuccgg     1740

gacggaccuc acugcguauc aaguugucca cauggcgucu ugggugccaa agggcccaua     1800

uacaaguauc cugacgugca gaaugaaugc cgaccauguc acgagaacug cacacagggc     1860

uguaagggac ccgaacugca agacugccuc ggccagacuc ugguucuuau cgggaaaacc     1920

caucugacaa uggcuuugac cgugauugcc ggacucgucg ugaucuuuau gaugcugggc     1980

gguacuuucu uauacuggag agggaggcgc auacagaaua agcgggcaau gagaagguac     2040

cuggagcgcg gagaguccau ugaaccgcua gauccuagcg agaaagccaa caagguacuc     2100

gcucgaaucu uuaaagaaac ggagcugcgg aaacuuaagg uguugggcuc ugguguuuuc     2160

ggcacagucc acaagggggu guggauccca gagggagaau caauuaagau ccccgugugu     2220

auuaaaguca uagaggacaa gaguggccgu cagagcuuuc aagcgguuac cgaucacaug     2280

cuggcaaucg ggucccucga ccaugcccac auugugagac uguuaggacu gugcccuggc     2340

ucuagucuuc aguuggugac ucaguaucuc ccccugggua gccuacugga ucauguaagg     2400

cagcaccgcg gggcucucgg accacaacug cuuuugaauu ggggcgucca gaucgccaaa     2460

gguauguacu aucuggaaga acauggcaug gugcaccgga acuuagcagc cagaaauguu     2520

cuccugaagu ccccuucaca ggugcaaguc gcugacuucg ggguggccga ucuucugccc     2580

ccagacgaua agcaguugcu cuacagugaa gcaaaaaccc cgaucaagug gauggcgcug     2640

gagucuauuc acuuuggaaa auauacacau cagagcgacg uuugguccua cggccagugc     2700

auauggaugc cuucacuacc cagccuggcu ccagugucua accuccccuu cgagaccccu     2760

uccuga                                                                2766


<210>  1460
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ErbB3__Homo_sapiens__BAG57868

<400>  1460
augagagcca acgacgcccu gcaggugcug ggccugcugu ucagccuggc cagaggcagc       60

gaggugggca acagccaggc cgugugcccc ggcacccuga acggccugag cgugaccggc      120

gacgccgaga accaguacca gacccuguac aagcuguacg agagaugcga gguggugaug      180

ggcaaccugg agaucgugcu gaccggccac aacgccgacc ugagcuuccu gcaguggauc      240

agagagguga ccggcuacgu gcugguggcc augaacgagu ucagcacccu gccccugccc      300

aaccugagag uggugagagg cacccaggug uacgacggca aguucgccau cuucgugaug      360

cugaacuaca acaccaacag cagccacgcc cugagacagc ugagacugac ccagcugacc      420

gagauccuga gcggcggcgu guacaucgag aagaacgaca agcugugcca cauggacacc      480

aucgacugga gagacaucgu gagagacaga gacgccgaga ucguggugaa ggacaacggc      540

agaagcugcc cccccugcca cgaggugugc aagggcagau gcuggggccc cggcagcgag      600

gacugccaga cccugaccaa gaccaucugc gccccccagu gcaacggcca cugcuucggc      660

cccaacccca accagugcug ccacgacgag ugcgccggcg gcugcagcgg cccccaggac      720

accgacugcu ucgccugcag acacuucaac gacagcggcg ccugcgugcc cagaugcccc      780

cagccccugg uguacaacaa gcugaccuuc cagcuggagc ccaaccccca caccaaguac      840

caguacggcg gcgugugcgu ggccagcugc ccccacaacu ucguggugga ccagaccagc      900

ugcgugagag ccugcccccc cgacaagaug gagguggaca agaacggccu gaagaugugc      960

gagcccugcg gcggccugug ccccaaggcc ugcgagggca ccggcagcgg cagcagauuc     1020

cagaccgugg acagcagcaa caucgacggc uucgugaacu gcaccaagau ccugggcaac     1080

cuggacuucc ugaucaccgg ccugaacggc gaccccuggc acaagauccc cgcccuggac     1140

cccgagaagc ugaacguguu cagaaccgug agagagauca ccggcuaccu gaacauccag     1200

agcuggcccc cccacaugca caacuucagc guguucagca accugaccac caucggcggc     1260

agaagccugu acaacagagg cuucagccug cugaucauga agaaccugaa cgugaccagc     1320

cugggcuuca gaagccugaa ggagaucagc gccggcagaa ucuacaucag cgccaacaga     1380

cagcugugcu accaccacag ccugaacugg accaaggugc ugagaggccc caccgaggag     1440

agacuggaca ucaagcacaa cagacccaga agagacugcg uggccgaggg caaggugugc     1500

gacccccugu gcagcagcgg cggcugcugg ggccccggcc ccggccagug ccugagcugc     1560

agaaacuaca gcagaggcgg cgugugcgug acccacugca acuuccugaa cggcgagccc     1620

agagaguucg cccacgaggc cgagugcuuc agcugccacc ccgagugcca gcccauggag     1680

ggcaccgcca ccugcaacgg cagcggcagc gacaccugcg cccagugcgc ccacuucaga     1740

gacggccccc acugcgugag cagcugcccc cacggcgugc ugggcgccaa gggccccauc     1800

uacaaguacc ccgacgugca gaacgagugc agacccugcc acgagaacug cacccagggc     1860

ugcaagggcc ccgagcugca ggacugccug ggccagaccc uggugcugau cggcaagacc     1920

caccugacca uggcccugac cgugaucgcc ggccuggugg ugaucuucau gaugcugggc     1980

ggcaccuucc uguacuggag aggcagaaga auccagaaca agagagccau gagaagauac     2040

cuggagagag gcgagagcau cgagccccug gaccccagcg agaaggccaa caaggugcug     2100

gccagaaucu ucaaggagac cgagcugaga aagcugaagg ugcugggcag cggcguguuc     2160

ggcaccgugc acaagggcgu guggaucccc gagggcgaga gcaucaagau ccccgugugc     2220

aucaagguga ucgaggacaa gagcggcaga cagagcuucc aggccgugac cgaccacaug     2280

cuggccaucg gcagccugga ccacgcccac aucgugagac ugcugggccu gugccccggc     2340

agcagccugc agcuggugac ccaguaccug ccccugggca gccugcugga ccacgugaga     2400

cagcacagag gcgcccuggg cccccagcug cugcugaacu ggggcgugca gaucgccaag     2460

ggcauguacu accuggagga gcacggcaug gugcacagaa accuggccgc cagaaacgug     2520

cugcugaaga gccccagcca ggugcaggug gccgacuucg gcguggccga ccugcugccc     2580

cccgacgaca agcagcugcu guacagcgag gccaagaccc ccaucaagug gauggcccug     2640

gagagcaucc acuucggcaa guacacccac cagagcgacg uguggagcua cggccagugc     2700

aucuggaugc ccagccugcc cagccuggcc cccgugagca accugcccuu cgagaccccc     2760

agcuga                                                                2766


<210>  1461
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ErbB3__Homo_sapiens__BAG57868

<400>  1461
augagagcca acgacgcucu ccaggugcug ggccugcuuu ucagccuggc ccgggggucc       60

gaggucggaa auucucaagc gguuugcccc ggcacccuca acgggcugag cgugacagga      120

gaugcugaaa aucaguacca gacgcuuuau aagcuguacg agcgcuguga aguggucaug      180

ggcaaccucg agaucgugcu gaccgggcac aaugccgacc uguccuuucu ccaguggauu      240

agagaaguua caggauaugu gcuggucgcc augaacgagu ucucuacccu uccucugccg      300

aaucuccggg ugguucgcgg cacacaagug uacgauggca aauuugcuau cuucgucaug      360

cugaacuaua auaccaacag cucccaugcc cuuagacagc ugcggcucac acagcugacc      420

gagauucugu cugggggagu guacaucgaa aagaaugaca aacucugcca cauggauacg      480

auugacuggc gcgauaucgu gagagaccgg gaugcugaga ucgucguuaa ggacaacggc      540

cgcagcuguc ccccuugcca ugaagugugu aaagggagau gcuggggacc cggcuccgag      600

gauugucaga cccugacaaa gaccauuugc gccccucaau guaaugggca cugcuuugga      660

cccaacccua aucaguguug ccaugacgag ugcgcgggcg gcuguagcgg gccgcaggau      720

acagacugcu ucgccugucg gcacuuuaac gacucuggag cuugcgugcc ccgcuguccu      780

cagccccuug ucuauaacaa gcugaccuuc caacucgaac cuaaucccca cacgaaauac      840

caguacggcg gggugugcgu ugccuccugu ccgcauaacu uuguggucga ucagacaagc      900

ugcgugagag cuuguccucc cgacaagaug gagguugaua aaaauggacu gaagaugugc      960

gaaccuugug gcgggcuuug ccccaaagcc ugcgagggaa ccggcucugg cucccgguuc     1020

caaacagugg acagcucuaa caucgauggg uuugucaauu guaccaagau ucugggaaac     1080

cucgacuucc ugaucaccgg ccugaauggg gaucccuggc acaagauucc ugcgcucgac     1140

ccggaaaaac ugaacguguu ucgcacaguc agagagauca cgggauaucu uaauauucag     1200

uccuggcccc cucauaugca caacuucagc guguucucca aucugaccac aaucggcggg     1260

cggucucucu acaacagagg cuuuagccug cuuaucauga agaaucugaa cguuaccucc     1320

cucggauucc gcagccugaa agagauuucu gccggccgga ucuauauuuc cgcuaauaga     1380

cagcugugcu accaccauag ccucaacugg acaaaggugc ugcgcgggcc caccgaagaa     1440

cggcuugaua ucaaacacaa cagaccucgc cgggacugug ucgccgaagg aaaggugugc     1500

gauccccugu guucuagcgg cgggugcugg ggaccgggcc cugggcagug ucucuccugc     1560

agaaauuauu cucgcggcgg aguuugugug acgcauugca acuuucugaa uggcgagccc     1620

cgggaguucg cucacgaggc cgaguguuuu agcugccauc cugaaugcca acccauggag     1680

gggacagcca ccuguaacgg auccggcagc gauaccugcg cucagugugc gcacuucaga     1740

gacgggccuc acugcgucuc uuccuguccc cauggagugc ugggcgccaa agggccgauu     1800

uacaaguauc cugacgugca gaaugaaugc cgccccuguc acgagaacug cacacagggc     1860

uguaagggac ccgaacuuca agacugccuc ggccagaccc ugguucugau cgggaaaaca     1920

caucucacga uggcucugac cgucaucgcc ggacuugugg ugauuuuuau gaugcugggc     1980

gggacauucc ucuacuggcg gggaagacgg auccagaaua agcgcgccau gagacgguac     2040

cuggagagag gcgagagcau ugaaccucug gauccgucug agaaagcuaa caagguccuu     2100

gcccgcaucu uuaaagaaac cgagcuccgg aagcugaagg ugcugggguc cggcguuuuc     2160

ggaacagugc acaaaggcgu cuggauuccc gagggggaaa gcaucaagau cccugugugu     2220

auuaaaguua ucgaggacaa guccggaaga cagucuuuuc aagcggugac cgaucacaug     2280

cucgcuauug gcagccugga ccaugcccac aucguccgcc uucuggggcu cugccccgga     2340

uccucucugc agcuggugac gcaguaucuu ccucucggca gccugcugga ucauguuaga     2400

cagcaccggg gcgcccucgg gccccaacug cuucugaauu ggggagugca gauugcuaaa     2460

ggcauguacu aucucgagga acaugggaug guccaccgca accuggccgc uagaaaugug     2520

cugcuuaagu ccccuagcca ggugcaaguc gccgacuucg gaguugcgga ucuccugccc     2580

ccggacgaua agcagcugcu cuacucugaa gccaaaaccc cuaucaagug gauggcucug     2640

gaguccauuc acuuuggcaa auauacacau cagagcgacg uguggucuua cgggcagugc     2700

aucuggaugc ccucccuucc uagccuggcc cccgugucua accucccguu cgagaccccu     2760

agcuga                                                                2766


<210>  1462
<211>  1308
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ERBB4__Homo_sapiens__Q15303

<400>  1462

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu 
        995                 1000                1005            


Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val 
    1010                1015                1020                


Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg 
1025                1030                1035                1040


Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr 
                1045                1050                1055    


Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala 
            1060                1065                1070        


Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile 
        1075                1080                1085            


Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp 
    1090                1095                1100                


Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln 
1105                1110                1115                1120


Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala 
                1125                1130                1135    


Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr 
            1140                1145                1150        


Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu 
        1155                1160                1165            


Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp 
    1170                1175                1180                


Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp 
1185                1190                1195                1200


Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu 
                1205                1210                1215    


Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys 
            1220                1225                1230        


Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro 
        1235                1240                1245            


Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr 
    1250                1255                1260                


Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu 
1265                1270                1275                1280


Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu 
                1285                1290                1295    


Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val 
            1300                1305            


<210>  1463
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ERBB4__Homo_sapiens__AAB59446

<400>  1463
augaagccgg cgacaggacu uugggucugg gugagccuuc ucguggcggc ggggaccguc       60

cagcccagcg auucucaguc agugugugca ggaacggaga auaaacugag cucucucucu      120

gaccuggaac agcaguaccg agccuugcgc aaguacuaug aaaacuguga gguugucaug      180

ggcaaccugg agauaaccag cauugagcac aaccgggacc ucuccuuccu gcggucuguu      240

cgagaaguca caggcuacgu guuaguggcu cuuaaucagu uucguuaccu gccucuggag      300

aauuuacgca uuauucgugg gacaaaacuu uaugaggauc gauaugccuu ggcaauauuu      360

uuaaacuaca gaaaagaugg aaacuuugga cuucaagaac uuggauuaaa gaacuugaca      420

gaaauccuaa augguggagu cuauguagac cagaacaaau uccuuuguua ugcagacacc      480

auucauuggc aagauauugu ucggaaccca uggccuucca acuugacucu ugugucaaca      540

aaugguaguu caggaugugg acguugccau aaguccugua cuggccguug cuggggaccc      600

acagaaaauc auugccagac uuugacaagg acggugugug cagaacaaug ugacggcaga      660

ugcuacggac cuuacgucag ugacugcugc caucgagaau gugcuggagg cugcucagga      720

ccuaaggaca cagacugcuu ugccugcaug aauuucaaug acaguggagc auguguuacu      780

cagugucccc aaaccuuugu cuacaaucca accaccuuuc aacuggagca caauuucaau      840

gcaaaguaca cauauggagc auucuguguc aagaaauguc cacauaacuu ugugguagau      900

uccaguucuu gugugcgugc cugcccuagu uccaagaugg aaguagaaga aaaugggauu      960

aaaaugugua aaccuugcac ugacauuugc ccaaaagcuu gugauggcau uggcacagga     1020

ucauugaugu cagcucagac uguggauucc aguaacauug acaaauucau aaacuguacc     1080

aagaucaaug ggaauuugau cuuucuaguc acugguauuc auggggaccc uuacaaugca     1140

auugaagcca uagacccaga gaaacugaac gucuuucgga cagucagaga gauaacaggu     1200

uuccugaaca uacagucaug gccaccaaac augacugacu ucaguguuuu uucuaaccug     1260

gugaccauug guggaagagu acucuauagu ggccuguccu ugcuuauccu caagcaacag     1320

ggcaucaccu cucuacaguu ccagucccug aaggaaauca gcgcaggaaa caucuauauu     1380

acugacaaca gcaaccugug uuauuaucau accauuaacu ggacaacacu cuucagcaca     1440

aucaaccaga gaauaguaau ccgggacaac agaaaagcug aaaauuguac ugcugaagga     1500

auggugugca accaucugug uuccagugau ggcuguuggg gaccugggcc agaccaaugu     1560

cugucguguc gccgcuucag uagaggaagg aucugcauag agucuuguaa ccucuaugau     1620

ggugaauuuc gggaguuuga gaauggcucc aucugugugg agugugaccc ccagugugag     1680

aagauggaag auggccuccu cacaugccau ggaccggguc cugacaacug uacaaagugc     1740

ucucauuuua aagauggccc aaacugugug gaaaaauguc cagauggcuu acagggggca     1800

aacaguuuca uuuucaagua ugcugaucca gaucgggagu gccacccaug ccauccaaac     1860

ugcacccaag gguguaacgg ucccacuagu caugacugca uuuacuaccc auggacgggc     1920

cauuccacuu uaccacaaca ugcuagaacu ccccugauug cagcuggagu aauugguggg     1980

cucuucauuc uggucauugu gggucugaca uuugcuguuu auguuagaag gaagagcauc     2040

aaaaagaaaa gagccuugag aagauucuug gaaacagagu ugguggaacc auuaacuccc     2100

aguggcacag cacccaauca agcucaacuu cguauuuuga aagaaacuga gcugaagagg     2160

guaaaagucc uuggcucagg ugcuuuugga acgguuuaua aagguauuug gguaccugaa     2220

ggagaaacug ugaagauucc uguggcuauu aagauucuua augagacaac uggucccaag     2280

gcaaaugugg aguucaugga ugaagcucug aucauggcaa guauggauca uccacaccua     2340

guccgguugc ugggugugug ucugagccca accauccagc ugguuacuca acuuaugccc     2400

cauggcugcc uguuggagua uguccacgag cacaaggaua acauuggauc acaacugcug     2460

cuuaacuggu guguccagau agcuaaggga augauguacc uggaagaaag acgacucguu     2520

caucgggauu uggcagcccg uaaugucuua gugaaaucuc caaaccaugu gaaaaucaca     2580

gauuuugggc uagccagacu cuuggaagga gaugaaaaag aguacaaugc ugauggagga     2640

aagaugccaa uuaaauggau ggcucuggag uguauacauu acaggaaauu cacccaucag     2700

agugacguuu ggagcuaugg aguuacuaua ugggaacuga ugaccuuugg aggaaaaccc     2760

uaugauggaa uuccaacgcg agaaaucccu gauuuauuag agaaaggaga acguuugccu     2820

cagccuccca ucugcacuau ugacguuuac auggucaugg ucaaauguug gaugauugau     2880

gcugacagua gaccuaaauu uaaggaacug gcugcugagu uuucaaggau ggcucgagac     2940

ccucaaagau accuaguuau ucagggugau gaucguauga agcuucccag uccaaaugac     3000

agcaaguucu uucagaaucu cuuggaugaa gaggauuugg aagauaugau ggaugcugag     3060

gaguacuugg ucccucaggc uuucaacauc ccaccuccca ucuauacuuc cagagcaaga     3120

auugacucga auaggaguga aauuggacac agcccuccuc cugccuacac ccccauguca     3180

ggaaaccagu uuguauaccg agauggaggu uuugcugcug aacaaggagu gucugugccc     3240

uacagagccc caacuagcac aauuccagaa gcuccugugg cacagggugc uacugcugag     3300

auuuuugaug acuccugcug uaauggcacc cuacgcaagc caguggcacc ccauguccaa     3360

gaggacagua gcacccagag guacagugcu gaccccaccg uguuugcccc agaacggagc     3420

ccacgaggag agcuggauga ggaagguuac augacuccua ugcgagacaa acccaaacaa     3480

gaauaccuga auccagugga ggagaacccu uuuguuucuc ggagaaaaaa uggagaccuu     3540

caagcauugg auaaucccga auaucacaau gcauccaaug guccacccaa ggccgaggau     3600

gaguauguga augagccacu guaccucaac accuuugcca acaccuuggg aaaagcugag     3660

uaccugaaga acaacauacu gucaaugcca gagaaggcca agaaagcguu ugacaacccu     3720

gacuacugga accacagccu gccaccucgg agcacccuuc agcacccaga cuaccugcag     3780

gaguacagca caaaauauuu uuauaaacag aaugggcgga uccggccuau uguggcagag     3840

aauccugaau accucucuga guucucccug aagccaggca cugugcugcc gccuccaccu     3900

uacagacacc ggaauacugu gguguaa                                         3927


<210>  1464
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ERBB4__Homo_sapiens__AAB59446

<400>  1464
augaagcccg ccaccggccu gugggugugg gucagccucc ugguggccgc ggggaccgug       60

cagcccuccg acagccaguc cgucugcgcc ggcacggaga acaagcugag cucccucagc      120

gaccuggagc agcaguaccg cgcccugcgg aaguacuacg agaacugcga gguggugaug      180

gggaaccucg agaucaccuc caucgagcac aaccgcgacc ugagcuuccu gcgguccguc      240

cgcgagguga ccggcuacgu gcucgucgcc cugaaccagu uccgguaccu gccccucgag      300

aaccugcgca ucauccgggg gaccaagcug uacgaggacc gcuacgcccu cgcgaucuuc      360

cugaacuacc ggaaggacgg caacuucggc cugcaggagc ucgggcugaa gaaccugacg      420

gagauccuca acggcggggu guacguggac cagaacaagu uccugugcua cgccgacacc      480

auccacuggc aggacaucgu ccgcaacccc uggcccagca accugacccu cguguccacc      540

aacggcagcu ccgggugcgg ccggugccac aagagcugca cgggccgcug cugggggccg      600

accgagaacc acugccagac ccugacccgg acggugugcg ccgagcagug cgacggccgc      660

ugcuacgggc ccuacgucuc cgacugcugc caccgggagu gcgccggcgg cugcagcggg      720

cccaaggaca ccgacugcuu cgcgugcaug aacuucaacg acuccggcgc cugcgugacc      780

cagugccccc agaccuucgu guacaacccg acgaccuucc agcuggagca caacuucaac      840

gccaaguaca ccuacggggc cuucugcguc aagaagugcc cccacaacuu cgugguggac      900

agcuccagcu gcguccgcgc cugccccagc uccaagaugg agguggagga gaacggcauc      960

aagaugugca agcccugcac cgacaucugc ccgaaggcgu gcgacgggau cggcacgggc     1020

agccucaugu ccgcccagac cguggacagc uccaacaucg acaaguucau caacugcacc     1080

aagaucaacg ggaaccugau cuuccugguc accggcaucc acggggaccc cuacaacgcc     1140

aucgaggcca ucgaccccga gaagcucaac guguuccgga cgguccgcga gaucaccggc     1200

uuccugaaca uccagagcug gcccccgaac augaccgacu ucuccguguu cagcaaccug     1260

gugaccaucg ggggccgggu ccucuacucc ggccugagcc ugcucauccu gaagcagcag     1320

gggaucacgu cccugcaguu ccagagccuc aaggagaucu ccgccggcaa caucuacauc     1380

accgacaaca gcaaccugug cuacuaccac accaucaacu ggaccacgcu guucuccacc     1440

aucaaccagc gcaucgugau ccgggacaac cgcaaggcgg agaacugcac cgccgagggg     1500

auggugugca accaccucug cagcuccgac ggcugcuggg ggcccggccc cgaccagugc     1560

cugagcugcc gccgguucuc ccgcggccgg aucugcaucg agagcugcaa ccuguacgac     1620

ggggaguucc gcgaguucga gaacggcagc aucugcgucg agugcgaccc ccagugcgag     1680

aagauggagg acgggcuccu gaccugccac ggcccgggcc ccgacaacug cacgaagugc     1740

ucccacuuca aggacgggcc caacugcgug gagaagugcc ccgacggccu gcagggggcc     1800

aacagcuuca ucuucaagua cgccgacccg gaccgggagu gccaccccug ccaccccaac     1860

ugcacccagg gcugcaacgg gcccaccucc cacgacugca ucuacuaccc guggaccggc     1920

cacagcaccc ucccccagca cgcccgcacg ccccugaucg cggccggcgu gaucgggggc     1980

cuguucaucc uggucaucgu ggggcucacc uucgccgugu acguccggcg caaguccauc     2040

aagaagaagc gggcccugcg ccgguuccug gagaccgagc ucguggagcc gcugaccccc     2100

agcggcacgg cccccaacca ggcgcagcug cgcauccuca aggagaccga gcugaagcgg     2160

gugaaggucc ugggguccgg cgccuucggc accguguaca aggggaucug ggugcccgag     2220

ggcgagaccg ucaagauccc gguggccauc aagauccuca acgagacgac cgggcccaag     2280

gccaacgugg aguucaugga cgaggcgcug aucauggcca gcauggacca cccccaccug     2340

guccgccucc ugggcgugug ccuguccccc accauccagc ucgugaccca gcugaugccg     2400

cacgggugcc ugcucgagua cguccacgag cacaaggaca acaucggcag ccagcugcug     2460

cucaacuggu gcgugcagau cgccaagggc augauguacc uggaggagcg gcgccuggug     2520

caccgggacc ucgccgcccg caacguccug gugaaguccc ccaaccacgu gaagaucacg     2580

gacuucgggc uggcgcggcu ccuggagggc gacgagaagg aguacaacgc cgacgggggc     2640

aagaugccca ucaaguggau ggcccuggag ugcauccacu accgcaaguu cacccaccag     2700

agcgacgucu gguccuacgg ggugaccauc ugggagcuca ugaccuucgg cggcaagccc     2760

uacgacggga ucccgacgcg cgagaucccc gaccugcugg agaagggcga gcggcucccc     2820

cagcccccga ucugcaccau cgacguguac auggucaugg ugaagugcug gaugaucgac     2880

gccgacagcc gccccaaguu caaggagcug gccgcggagu ucucccggau ggcccgcgac     2940

ccccagcggu accuggugau ccagggggac gaccgcauga agcuccccag cccgaacgac     3000

uccaaguucu uccagaaccu gcuggacgag gaggaccucg aggacaugau ggacgccgag     3060

gaguaccugg ucccccaggc cuucaacauc ccgcccccga ucuacaccag ccgggcccgc     3120

aucgacagca accgguccga gaucggccac agcccgccgc ccgcguacac ccccaugucc     3180

ggcaaccagu ucguguaccg cgacgggggc uucgccgccg agcagggggu gagcgucccc     3240

uaccgggccc ccacguccac cauccccgag gcgcccgugg cccagggcgc caccgccgag     3300

aucuucgacg acagcugcug caacgggacc cugcgcaagc ccguggcgcc ccacguccag     3360

gaggacucca gcacgcagcg guacuccgcc gaccccaccg uguucgcccc cgagcgcagc     3420

ccccggggcg agcucgacga ggagggcuac augaccccca ugcgcgacaa gccgaagcag     3480

gaguaccuga accccgugga ggagaacccc uucgucuccc ggcgcaagaa cggggaccug     3540

caggcccucg acaaccccga guaccacaac gccagcaacg gcccgcccaa ggccgaggac     3600

gaguacguga acgagccccu guaccugaac accuucgcga acacgcucgg gaaggccgag     3660

uaccugaaga acaacauccu guccaugccc gagaaggcca agaaggccuu cgacaacccg     3720

gacuacugga accacagccu cccgccccgg uccacccugc agcaccccga cuaccugcag     3780

gaguacagca ccaaguacuu cuacaagcag aacggccgca uccggcccau cguggccgag     3840

aaccccgagu accucuccga guucagccug aagcccggga ccguccugcc cccgccgccc     3900

uaccgccacc gcaacacggu gguguga                                         3927


<210>  1465
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ERBB4__Homo_sapiens__AAB59446

<400>  1465
augaagcccg ccaccggccu cugggucugg gucucccucc ucgucgccgc cggcaccguc       60

cagcccuccg acucccaguc cgucugcgcc ggcaccgaga acaagcucuc cucccucucc      120

gaccucgagc agcaguaccg cgcccuccgc aaguacuacg agaacugcga ggucgucaug      180

ggcaaccucg agaucaccuc caucgagcac aaccgcgacc ucuccuuccu ccgcuccguc      240

cgcgagguca ccggcuacgu ccucgucgcc cucaaccagu uccgcuaccu cccccucgag      300

aaccuccgca ucauccgcgg caccaagcuc uacgaggacc gcuacgcccu cgccaucuuc      360

cucaacuacc gcaaggacgg caacuucggc cuccaggagc ucggccucaa gaaccucacc      420

gagauccuca acggcggcgu cuacgucgac cagaacaagu uccucugcua cgccgacacc      480

auccacuggc aggacaucgu ccgcaacccc uggcccucca accucacccu cgucuccacc      540

aacggcuccu ccggcugcgg ccgcugccac aaguccugca ccggccgcug cuggggcccc      600

accgagaacc acugccagac ccucacccgc accgucugcg ccgagcagug cgacggccgc      660

ugcuacggcc ccuacgucuc cgacugcugc caccgcgagu gcgccggcgg cugcuccggc      720

cccaaggaca ccgacugcuu cgccugcaug aacuucaacg acuccggcgc cugcgucacc      780

cagugccccc agaccuucgu cuacaacccc accaccuucc agcucgagca caacuucaac      840

gccaaguaca ccuacggcgc cuucugcguc aagaagugcc cccacaacuu cgucgucgac      900

uccuccuccu gcguccgcgc cugccccucc uccaagaugg aggucgagga gaacggcauc      960

aagaugugca agcccugcac cgacaucugc cccaaggccu gcgacggcau cggcaccggc     1020

ucccucaugu ccgcccagac cgucgacucc uccaacaucg acaaguucau caacugcacc     1080

aagaucaacg gcaaccucau cuuccucguc accggcaucc acggcgaccc cuacaacgcc     1140

aucgaggcca ucgaccccga gaagcucaac gucuuccgca ccguccgcga gaucaccggc     1200

uuccucaaca uccaguccug gccccccaac augaccgacu ucuccgucuu cuccaaccuc     1260

gucaccaucg gcggccgcgu ccucuacucc ggccucuccc uccucauccu caagcagcag     1320

ggcaucaccu cccuccaguu ccagucccuc aaggagaucu ccgccggcaa caucuacauc     1380

accgacaacu ccaaccucug cuacuaccac accaucaacu ggaccacccu cuucuccacc     1440

aucaaccagc gcaucgucau ccgcgacaac cgcaaggccg agaacugcac cgccgagggc     1500

auggucugca accaccucug cuccuccgac ggcugcuggg gccccggccc cgaccagugc     1560

cucuccugcc gccgcuucuc ccgcggccgc aucugcaucg aguccugcaa ccucuacgac     1620

ggcgaguucc gcgaguucga gaacggcucc aucugcgucg agugcgaccc ccagugcgag     1680

aagauggagg acggccuccu caccugccac ggccccggcc ccgacaacug caccaagugc     1740

ucccacuuca aggacggccc caacugcguc gagaagugcc ccgacggccu ccagggcgcc     1800

aacuccuuca ucuucaagua cgccgacccc gaccgcgagu gccaccccug ccaccccaac     1860

ugcacccagg gcugcaacgg ccccaccucc cacgacugca ucuacuaccc cuggaccggc     1920

cacuccaccc ucccccagca cgcccgcacc ccccucaucg ccgccggcgu caucggcggc     1980

cucuucaucc ucgucaucgu cggccucacc uucgccgucu acguccgccg caaguccauc     2040

aagaagaagc gcgcccuccg ccgcuuccuc gagaccgagc ucgucgagcc ccucaccccc     2100

uccggcaccg cccccaacca ggcccagcuc cgcauccuca aggagaccga gcucaagcgc     2160

gucaaggucc ucggcuccgg cgccuucggc accgucuaca agggcaucug gguccccgag     2220

ggcgagaccg ucaagauccc cgucgccauc aagauccuca acgagaccac cggccccaag     2280

gccaacgucg aguucaugga cgaggcccuc aucauggccu ccauggacca cccccaccuc     2340

guccgccucc ucggcgucug ccucuccccc accauccagc ucgucaccca gcucaugccc     2400

cacggcugcc uccucgagua cguccacgag cacaaggaca acaucggcuc ccagcuccuc     2460

cucaacuggu gcguccagau cgccaagggc augauguacc ucgaggagcg ccgccucguc     2520

caccgcgacc ucgccgcccg caacguccuc gucaaguccc ccaaccacgu caagaucacc     2580

gacuucggcc ucgcccgccu ccucgagggc gacgagaagg aguacaacgc cgacggcggc     2640

aagaugccca ucaaguggau ggcccucgag ugcauccacu accgcaaguu cacccaccag     2700

uccgacgucu gguccuacgg cgucaccauc ugggagcuca ugaccuucgg cggcaagccc     2760

uacgacggca uccccacccg cgagaucccc gaccuccucg agaagggcga gcgccucccc     2820

cagcccccca ucugcaccau cgacgucuac auggucaugg ucaagugcug gaugaucgac     2880

gccgacuccc gccccaaguu caaggagcuc gccgccgagu ucucccgcau ggcccgcgac     2940

ccccagcgcu accucgucau ccagggcgac gaccgcauga agcuccccuc ccccaacgac     3000

uccaaguucu uccagaaccu ccucgacgag gaggaccucg aggacaugau ggacgccgag     3060

gaguaccucg ucccccaggc cuucaacauc ccccccccca ucuacaccuc ccgcgcccgc     3120

aucgacucca accgcuccga gaucggccac uccccccccc ccgccuacac ccccaugucc     3180

ggcaaccagu ucgucuaccg cgacggcggc uucgccgccg agcagggcgu cuccgucccc     3240

uaccgcgccc ccaccuccac cauccccgag gcccccgucg cccagggcgc caccgccgag     3300

aucuucgacg acuccugcug caacggcacc cuccgcaagc ccgucgcccc ccacguccag     3360

gaggacuccu ccacccagcg cuacuccgcc gaccccaccg ucuucgcccc cgagcgcucc     3420

ccccgcggcg agcucgacga ggagggcuac augaccccca ugcgcgacaa gcccaagcag     3480

gaguaccuca accccgucga ggagaacccc uucgucuccc gccgcaagaa cggcgaccuc     3540

caggcccucg acaaccccga guaccacaac gccuccaacg gcccccccaa ggccgaggac     3600

gaguacguca acgagccccu cuaccucaac accuucgcca acacccucgg caaggccgag     3660

uaccucaaga acaacauccu cuccaugccc gagaaggcca agaaggccuu cgacaacccc     3720

gacuacugga accacucccu ccccccccgc uccacccucc agcaccccga cuaccuccag     3780

gaguacucca ccaaguacuu cuacaagcag aacggccgca uccgccccau cgucgccgag     3840

aaccccgagu accucuccga guucucccuc aagcccggca ccguccuccc cccccccccc     3900

uaccgccacc gcaacaccgu cgucuga                                         3927


<210>  1466
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ERBB4__Homo_sapiens__AAB59446

<400>  1466
augaagcccg ccaccggccu gugggugugg gucagccucc uuguugcugc agggacagug       60

cagccuuccg acucucaauc aguaugcgcc ggaacugaaa acaaacugag uagcuugucc      120

gauuuagaac agcaguacag agcgcugagg aaguauuacg agaauuguga aguggucaug      180

gguaaccuag agaucacguc uauugaacac aaucgggacc ucucguuccu gcgcucagug      240

cgagagguua ccggcuaugu gcuugucgcu cugaaccagu uucguuacuu gccacucgag      300

aaucugagaa uaaucagggg gacaaaacug uaugaagauc gguacgcccu cgcaauuuuc      360

uuaaacuauc gcaaggacgg aaauuuuggc cugcaagagc uugguuugaa aaaccugacu      420

gaaauccuaa augggggagu guacguagau cagaacaagu uccucugcua cgccgacacc      480

auucauuggc aggauaucgu uagaaauccg uggcccagca accugacacu ugugaguacc      540

aauggcuccu cuggcugugg gaggugccac aagagcugua cuggacggug cugggguccu      600

acagagaacc auugucagac ccugacgcgc acugucugcg cugagcaaug ugacggccga      660

ugcuaugggc cauacguguc cgauuguugc cacagagaau gcgcaggagg cuguucaggu      720

cccaaagaca ccgauugcuu ugccuguaug aauuucaacg acaguggggc uugcgugaca      780

caguguccuc agacuuuugu cuauaaccca accacauucc aguuggagca uaauuuuaac      840

gccaaguaca ccuauggagc guucugcguu aaaaaguguc cccacaauuu ugugguagau      900

ucuagcuccu gcgugagggc auguccuuca agcaaaaugg aagucgagga aaacggcaua      960

aagaugugca agccauguac ggacaucugc ccgaaagccu gcgacggcau ugggacugga     1020

agucucaugu cugcucaaac aguggauucc agcaauaucg acaaguucau uaacuguacc     1080

aaaaucaaug guaaccugau auuuuuaguu acuggcauuc acggggaucc cuacaaugcc     1140

aucgaggcaa uugacccuga gaagcugaac guguuccgga caguccguga aaucaccgga     1200

uuccucaaua uccagucgug gccacccaac augacggauu uuucuguguu cuccaaucuu     1260

guaaccauug gcggucgcgu ucuguauuca ggguugaguc uacugauacu caaacagcaa     1320

ggcaucacaa gccugcaguu ucagucccuu aaggagauuu cugcuggaaa caucuacaua     1380

acugacaaua gcaaccugug cuacuaucau accauuaacu ggacaacuuu guucucaacc     1440

aucaaucaga gaaucgugau uagggauaac cggaaagccg aaaauuguac agcggagggc     1500

auggucugca accaccucug uaguuccgac gggugcuggg gaccuggucc agaucaaugu     1560

cugagcugcc gacgcuuuuc uagaggcagg aucuguauug aaucaugcaa uuuauacgac     1620

ggggaguucc gggaguuuga aaacggaagu auaugugugg agugcgaucc ccagugcgaa     1680

aagauggagg acggccugcu aaccugucau gguccggggc cugacaauug cacuaagugu     1740

agccacuuca aagauggccc caacugcguc gaaaaguguc cagacggacu ccagggcgcc     1800

aauuccuuua ucuucaaaua ugcagauccu gaccgcgagu gccaccccug ucauccaaac     1860

ugcacgcagg gguguaaugg acccacaucu cacgauugca uuuacuaucc uuggaccggu     1920

cauucgacuc ugccacaaca cgcuagaacc ccgcuuaucg ccgcuggcgu gaucggggga     1980

uuguuuauuc ugguuauagu gggccucaca uucgccguau acgucaggcg uaagagcauc     2040

aaaaagaagc gggcacugcg aagauuucuu gagaccgaac ugguggagcc cuugacuccu     2100

uccgguacag ccccaaacca ggcucagcuc aggauucuga aagaaacgga guuaaagcgc     2160

guuaaagugc uggggucagg cgcguucgga accgucuaua agggcaucug ggugcccgag     2220

ggggaaacug uaaaaauucc uguggcaauc aagauacuaa augagacaac cggaccaaag     2280

gccaacguug aguucaugga cgaagcucuc aucauggcca guauggauca uccccaccug     2340

guccggcuuu ugggcgugug ucugucuccg acaauucagc ucgugacuca acugaugccu     2400

cacgguugcu uacuggaaua cguccaugag cacaaagaca auaucgggag ccagcuuuug     2460

cucaacuggu gcguucagau ugcaaaggga augauguacc uggaggaaag aaggcuagug     2520

caucgcgauc uggccgcucg aaacgugcuc guaaaauccc caaaucacgu caagaucacc     2580

gacuuuggcc uggcccggcu uuuggagggu gaugaaaaag aguauaacgc agacggcggg     2640

aagaugccca uaaaguggau ggcgcuggaa uguauucacu accguaaauu cacgcaucag     2700

ucagaugugu ggagcuaugg aguuaccauc ugggaguuaa ugacauuugg cgggaagccu     2760

uacgacggca uucccacuag agagauccca gaccuccugg aaaaaggaga gaggcuuccu     2820

caacccccaa uaugcaccau cgauguguau auggucaugg ugaaguguug gaugauugac     2880

gcugauucuc gcccgaaauu caaggaacug gccgcagagu uuucccggau ggccagagac     2940

ccucagaggu acuugguuau ccagggugau gaccgaauga aacuccccag uccaaaugau     3000

agcaaguucu uucaaaaccu gcuagacgaa gaggaucugg aggacaugau ggaugcugaa     3060

gaguaucucg ugccccaggc cuucaauauu ccuccaccca ucuacacauc ucgcgcacgg     3120

auagacucca acagaucaga aauugggcac aguccuccgc cagcuuacac ucccaugagc     3180

ggaaaucagu uuguauauag ggauggcggu uucgccgcgg agcagggcgu cucggugccu     3240

uaccgugccc caaccuccac gauccccgag gcuccugugg cacaaggggc cacagcugaa     3300

aucuuugacg acucuugcug uaacggaacc cugcgcaagc cggucgcacc ccauguucag     3360

gaggauagcu caacucagcg guauagugcc gacccaacag uguucgcgcc ugaaagaucc     3420

cccaggggcg agcuugauga agagggguac augaccccaa ugcgagacaa accuaagcag     3480

gaguauuuga aucccguaga agagaaccca uuugugucuc ggcgcaaaaa uggagaucug     3540

caagccuuag acaacccgga auaccacaau gcuagcaacg gcccucccaa ggccgaggau     3600

gaauauguca augagccacu cuaccugaac acuuucgcaa acacccuugg uaaagcugag     3660

uaccugaaga auaacauucu auccaugccc gaaaaggcca aaaaggcauu cgacaauccu     3720

gauuauugga accauucacu cccacccaga agcacacugc agcacccuga cuacuugcag     3780

gaguauagua cgaaauacuu uuauaagcag aaugggagga uccggccgau uguggccgaa     3840

aacccagagu accugucuga guucuccuua aaacccggaa ccguucuccc ucccccaccu     3900

uaucgacaca gaaauacugu ggucuga                                         3927


<210>  1467
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ERBB4__Homo_sapiens__AAB59446

<400>  1467
augaagcccg ccaccggccu gugggugugg gugagccugc ugguggccgc cggcaccgug       60

cagcccagcg acagccagag cgugugcgcc ggcaccgaga acaagcugag cagccugagc      120

gaccuggagc agcaguacag agcccugaga aaguacuacg agaacugcga gguggugaug      180

ggcaaccugg agaucaccag caucgagcac aacagagacc ugagcuuccu gagaagcgug      240

agagagguga ccggcuacgu gcugguggcc cugaaccagu ucagauaccu gccccuggag      300

aaccugagaa ucaucagagg caccaagcug uacgaggaca gauacgcccu ggccaucuuc      360

cugaacuaca gaaaggacgg caacuucggc cugcaggagc ugggccugaa gaaccugacc      420

gagauccuga acggcggcgu guacguggac cagaacaagu uccugugcua cgccgacacc      480

auccacuggc aggacaucgu gagaaacccc uggcccagca accugacccu ggugagcacc      540

aacggcagca gcggcugcgg cagaugccac aagagcugca ccggcagaug cuggggcccc      600

accgagaacc acugccagac ccugaccaga accgugugcg ccgagcagug cgacggcaga      660

ugcuacggcc ccuacgugag cgacugcugc cacagagagu gcgccggcgg cugcagcggc      720

cccaaggaca ccgacugcuu cgccugcaug aacuucaacg acagcggcgc cugcgugacc      780

cagugccccc agaccuucgu guacaacccc accaccuucc agcuggagca caacuucaac      840

gccaaguaca ccuacggcgc cuucugcgug aagaagugcc cccacaacuu cgugguggac      900

agcagcagcu gcgugagagc cugccccagc agcaagaugg agguggagga gaacggcauc      960

aagaugugca agcccugcac cgacaucugc cccaaggccu gcgacggcau cggcaccggc     1020

agccugauga gcgcccagac cguggacagc agcaacaucg acaaguucau caacugcacc     1080

aagaucaacg gcaaccugau cuuccuggug accggcaucc acggcgaccc cuacaacgcc     1140

aucgaggcca ucgaccccga gaagcugaac guguucagaa ccgugagaga gaucaccggc     1200

uuccugaaca uccagagcug gccccccaac augaccgacu ucagcguguu cagcaaccug     1260

gugaccaucg gcggcagagu gcuguacagc ggccugagcc ugcugauccu gaagcagcag     1320

ggcaucacca gccugcaguu ccagagccug aaggagauca gcgccggcaa caucuacauc     1380

accgacaaca gcaaccugug cuacuaccac accaucaacu ggaccacccu guucagcacc     1440

aucaaccaga gaaucgugau cagagacaac agaaaggccg agaacugcac cgccgagggc     1500

auggugugca accaccugug cagcagcgac ggcugcuggg gccccggccc cgaccagugc     1560

cugagcugca gaagauucag cagaggcaga aucugcaucg agagcugcaa ccuguacgac     1620

ggcgaguuca gagaguucga gaacggcagc aucugcgugg agugcgaccc ccagugcgag     1680

aagauggagg acggccugcu gaccugccac ggccccggcc ccgacaacug caccaagugc     1740

agccacuuca aggacggccc caacugcgug gagaagugcc ccgacggccu gcagggcgcc     1800

aacagcuuca ucuucaagua cgccgacccc gacagagagu gccaccccug ccaccccaac     1860

ugcacccagg gcugcaacgg ccccaccagc cacgacugca ucuacuaccc cuggaccggc     1920

cacagcaccc ugccccagca cgccagaacc ccccugaucg ccgccggcgu gaucggcggc     1980

cuguucaucc uggugaucgu gggccugacc uucgccgugu acgugagaag aaagagcauc     2040

aagaagaaga gagcccugag aagauuccug gagaccgagc ugguggagcc ccugaccccc     2100

agcggcaccg cccccaacca ggcccagcug agaauccuga aggagaccga gcugaagaga     2160

gugaaggugc ugggcagcgg cgccuucggc accguguaca agggcaucug ggugcccgag     2220

ggcgagaccg ugaagauccc cguggccauc aagauccuga acgagaccac cggccccaag     2280

gccaacgugg aguucaugga cgaggcccug aucauggcca gcauggacca cccccaccug     2340

gugagacugc ugggcgugug ccugagcccc accauccagc uggugaccca gcugaugccc     2400

cacggcugcc ugcuggagua cgugcacgag cacaaggaca acaucggcag ccagcugcug     2460

cugaacuggu gcgugcagau cgccaagggc augauguacc uggaggagag aagacuggug     2520

cacagagacc uggccgccag aaacgugcug gugaagagcc ccaaccacgu gaagaucacc     2580

gacuucggcc uggccagacu gcuggagggc gacgagaagg aguacaacgc cgacggcggc     2640

aagaugccca ucaaguggau ggcccuggag ugcauccacu acagaaaguu cacccaccag     2700

agcgacgugu ggagcuacgg cgugaccauc ugggagcuga ugaccuucgg cggcaagccc     2760

uacgacggca uccccaccag agagaucccc gaccugcugg agaagggcga gagacugccc     2820

cagcccccca ucugcaccau cgacguguac auggugaugg ugaagugcug gaugaucgac     2880

gccgacagca gacccaaguu caaggagcug gccgccgagu ucagcagaau ggccagagac     2940

ccccagagau accuggugau ccagggcgac gacagaauga agcugcccag ccccaacgac     3000

agcaaguucu uccagaaccu gcuggacgag gaggaccugg aggacaugau ggacgccgag     3060

gaguaccugg ugccccaggc cuucaacauc ccccccccca ucuacaccag cagagccaga     3120

aucgacagca acagaagcga gaucggccac agcccccccc ccgccuacac ccccaugagc     3180

ggcaaccagu ucguguacag agacggcggc uucgccgccg agcagggcgu gagcgugccc     3240

uacagagccc ccaccagcac cauccccgag gcccccgugg cccagggcgc caccgccgag     3300

aucuucgacg acagcugcug caacggcacc cugagaaagc ccguggcccc ccacgugcag     3360

gaggacagca gcacccagag auacagcgcc gaccccaccg uguucgcccc cgagagaagc     3420

cccagaggcg agcuggacga ggagggcuac augaccccca ugagagacaa gcccaagcag     3480

gaguaccuga accccgugga ggagaacccc uucgugagca gaagaaagaa cggcgaccug     3540

caggcccugg acaaccccga guaccacaac gccagcaacg gcccccccaa ggccgaggac     3600

gaguacguga acgagccccu guaccugaac accuucgcca acacccuggg caaggccgag     3660

uaccugaaga acaacauccu gagcaugccc gagaaggcca agaaggccuu cgacaacccc     3720

gacuacugga accacagccu gccccccaga agcacccugc agcaccccga cuaccugcag     3780

gaguacagca ccaaguacuu cuacaagcag aacggcagaa ucagacccau cguggccgag     3840

aaccccgagu accugagcga guucagccug aagcccggca ccgugcugcc cccccccccc     3900

uacagacaca gaaacaccgu gguguga                                         3927


<210>  1468
<211>  3927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ERBB4__Homo_sapiens__AAB59446

<400>  1468
augaagcccg ccaccggccu gugggugugg gucagccucc ugguugcugc cgggacagug       60

cagccuuccg acucucaaag cgugugcgcg ggaacggaaa acaaacuuuc cucucugagc      120

gaucucgaac agcaguacag agcucugcgg aaguauuacg agaauuguga agucgugaug      180

ggcaaccuug agaucaccuc cauugaacac aaucgcgacc ugucuuuccu cagaagcguu      240

cgggagguga caggguaugu ccugguggcc cugaaccagu uucgcuaccu cccgcuggag      300

aaucuuagaa ucauucgggg aaccaaacug uaugaagauc gcuacgcccu cgcuaucuuc      360

cugaacuaua gaaaggacgg caauuuuggg cuucaagagc ugggacucaa aaaccugaca      420

gaaauucuga auggcggcgu uuacguggau cagaacaagu uccucugcua cgccgacacc      480

auccauuggc aggauaucgu ccggaauccc uggccuucca accugacacu ugugagcacc      540

aaugggucuu ccggaugugg ccgcugccac aagagcugua cggggagaug cuggggaccc      600

accgagaacc auugucagac acugacccgg acagugugcg cugagcaaug ugacggccgc      660

ugcuaugggc cuuacgucuc ugauuguugc cacagagaau gcgccggagg cuguuccggc      720

cccaaagaca ccgauugcuu ugcguguaug aauuucaacg acagcggggc cugcguuacg      780

caguguccuc agacauuugu guauaacccg accacauucc agcucgagca uaauuuuaac      840

gcuaaguaca ccuauggagc cuucugcgug aaaaaguguc cccacaauuu ugucguggau      900

ucuuccagcu gcguucgggc uuguccuucc ucuaaaaugg aaguggagga aaacggcauu      960

aagaugugca agcccuguac cgacaucugc ccuaaagccu gcgacgggau uggaacaggc     1020

agccugaugu ccgcgcaaac ggucgauagc ucuaauaucg acaaguucau uaacuguacc     1080

aaaaucaaug ggaaccuuau uuuucuggug acaggaaucc acggcgaucc cuacaaugcc     1140

aucgaggcua uugacccgga gaagcucaac guuuuccgca ccgugagaga aaucacaggc     1200

uuccugaaua uucaguccug gccucccaac augaccgauu uuagcgucuu cucuaaucug     1260

gugacgaucg ggggacgggu ccucuauagc ggccuguccc uucugauucu caaacagcaa     1320

gggaucacau cucugcaguu ucagagccuu aaggagaucu ccgccggaaa cauuuacauc     1380

accgacaaua gcaaccugug cuacuaucau accauuaacu ggacaacccu cuucucuaca     1440

aucaaucaga gaauugugau ccgcgauaac cggaaagcug aaaauuguac ggccgagggc     1500

augguuugca accaccugug uuccagcgac gggugcuggg gcccuggacc cgaucaaugu     1560

cugucuugca gacgcuuuuc ccggggcaga aucuguauug aaagcugcaa ucucuacgac     1620

ggggaguucc gcgaguuuga aaacggaucc aucugugugg agugcgaucc ccagugcgaa     1680

aagauggagg acggccugcu uaccugucau gggccuggac cggacaauug cacaaagugu     1740

ucucacuuca aagauggccc caacugcguc gaaaaguguc cugacgggcu gcagggcgcc     1800

aauagcuuua uuuucaaaua ugcugauccc gaccgggagu gccacccuug ucaucccaac     1860

ugcacccagg gauguaaugg cccgacaucc cacgauugca ucuacuaucc uuggaccggg     1920

cauucuacgc ucccccaaca cgcgagaacc ccucugauug ccgcuggagu gaucggcggg     1980

cuguuuauuc uuguuaucgu gggacucaca uucgccgucu acgugcgcag aaagagcauc     2040

aaaaagaaga gagcccugcg ccgguuucug gagaccgaac ucguggagcc ccugacaccu     2100

uccggcaccg cucccaacca ggcccagcuu cggauucuga aagaaacgga gcucaagcgg     2160

guuaaagucc uggggagcgg cgcguucgga acaguguaua agggcaucug ggugccggag     2220

ggggaaaccg ucaaaauucc uguggcuauc aagauucuga augagacaac cggacccaag     2280

gccaacguug aguucaugga cgaagcccuu aucauggcuu cuauggauca uccccaccuc     2340

gugcgccugc ugggcgucug ucucuccccu accauccagc uggugacaca acuuaugccg     2400

cacgggugcc ugcucgaaua cguucaugag cacaaagaca auauuggaag ccagcugcug     2460

cuuaacuggu gcgugcagau cgccaagggc augauguacc ucgaggaaag acggcugguc     2520

cauagagauc uggcugcccg caacgugcuc guuaaaucuc ccaaucacgu gaagauuacg     2580

gacuuugggc uggcgcggcu ucuggagggc gaugaaaaag aguauaacgc cgacggaggc     2640

aagaugccua ucaaguggau ggcucucgaa uguauucacu acagaaaauu cacccaucag     2700

uccgaugucu ggagcuaugg ggugacaauc ugggagcuga ugaccuuugg aggcaagccc     2760

uacgacggga ucccuacacg cgagauuccc gaccugcuug aaaaaggaga gagacucccu     2820

caacccccga ucugcaccau ugauguguau auggucaugg uuaaguguug gaugaucgac     2880

gccgauucuc ggccuaaauu caaggaacug gcugccgagu uuagccgcau ggcgagagac     2940

ccccagcggu accuggugau ucagggcgau gaccgcauga aacucccuuc ccccaaugau     3000

agcaaguucu uucaaaaccu gcuugacgaa gaggaucugg aggacaugau ggaugccgaa     3060

gaguaucucg ugccgcaggc uuucaauauc ccucccccua ucuacacguc uagagcccgg     3120

auugacucca accgcagcga aaucggccac uccccuccgc ccgcuuacac acccaugucu     3180

gggaaucagu uugucuauag agauggaggc uucgccgccg agcagggggu gagcguuccc     3240

uaccgggcuc cuaccuccac cauucccgag gcgccugugg cccaaggagc uacagccgaa     3300

aucuuugacg acucuugcug uaacggcacc cugcgcaagc ccgucgcccc ucaugugcag     3360

gaggauagcu ccacacagag auauucugcu gacccgacgg uuuucgcccc cgaacggagc     3420

ccuagagggg agcuggauga agagggauac augaccccca ugcgcgacaa accuaagcag     3480

gaguaucuua aucccgugga agagaacccg uuugucuccc ggcgcaaaaa uggcgaucug     3540

caagcgcucg acaacccuga auaccacaau gcuagcaacg gcccucccaa ggccgaggau     3600

gaauauguga augagccccu guaccucaac acauucgcca acacccuggg gaaagcugag     3660

uaccuuaaga auaacauucu gucuaugccc gaaaaggcca aaaaggcguu cgacaauccu     3720

gauuauugga accauucccu cccgcccaga agcacacugc agcacccuga cuaccugcag     3780

gaguauucua ccaaauacuu uuauaagcag aauggacgga ucagacccau uguugcugaa     3840

aacccugagu accuuuccga guucagccug aaacccggca cggugcuccc gccucccccu     3900

uaucgccacc ggaauaccgu cguguga                                         3927


<210>  1469
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ERG__Homo_sapiens__P11308

<400>  1469

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn 
225                 230                 235                 240 


Thr Ser Val Tyr Pro Glu Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp 
                245                 250                 255     


Leu Pro Tyr Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly His 
            260                 265                 270         


Pro Thr Pro Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val Pro 
        275                 280                 285             


Lys Thr Glu Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly 
    290                 295                 300                 


Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu 
305                 310                 315                 320 


Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys 
                325                 330                 335     


Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp 
            340                 345                 350         


Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn 
        355                 360                 365             


Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile 
    370                 375                 380                 


Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His 
385                 390                 395                 400 


Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu Tyr 
                405                 410                 415     


Lys Tyr Pro Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His Pro 
            420                 425                 430         


Gln Lys Met Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val Thr 
        435                 440                 445             


Ser Ser Ser Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr 
    450                 455                 460                 


Gly Gly Ile Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro Ser 
465                 470                 475                 480 


His Leu Gly Thr Tyr Tyr 
                485     


<210>  1470
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ERG__Homo_sapiens__CCDS46648.1

<400>  1470
augauucaga cugucccgga cccagcagcu cauaucaagg aagccuuauc aguugugagu       60

gaggaccagu cguuguuuga gugugccuac ggaacgccac accuggcuaa gacagagaug      120

accgcguccu ccuccagcga cuauggacag acuuccaaga ugagcccacg cgucccucag      180

caggauuggc ugucucaacc cccagccagg gucaccauca aaauggaaug uaacccuagc      240

caggugaaug gcucaaggaa cucuccugau gaaugcagug uggccaaagg cgggaagaug      300

gugggcagcc cagacaccgu ugggaugaac uacggcagcu acauggagga gaagcacaug      360

ccacccccaa acaugaccac gaacgagcgc agaguuaucg ugccagcaga uccuacgcua      420

uggaguacag accaugugcg gcaguggcug gagugggcgg ugaaagaaua uggccuucca      480

gacgucaaca ucuuguuauu ccagaacauc gaugggaagg aacugugcaa gaugaccaag      540

gacgacuucc agaggcucac ccccagcuac aacgccgaca uccuucucuc acaucuccac      600

uaccucagag agacuccucu uccacauuug acuucagaug auguugauaa agccuuacaa      660

aacucuccac gguuaaugca ugcuagaaac acagggggug cagcuuuuau uuucccaaau      720

acuucaguau auccugaagc uacgcaaaga auuacaacua ggccagauuu accauaugag      780

ccccccagga gaucagccug gaccggucac ggccacccca cgccccaguc gaaagcugcu      840

caaccaucuc cuuccacagu gcccaaaacu gaagaccagc guccucaguu agauccuuau      900

cagauucuug gaccaacaag uagccgccuu gcaaauccag gcaguggcca gauccagcuu      960

uggcaguucc uccuggagcu ccugucggac agcuccaacu ccagcugcau caccugggaa     1020

ggcaccaacg gggaguucaa gaugacggau cccgacgagg uggcccggcg cuggggagag     1080

cggaagagca aacccaacau gaacuacgau aagcucagcc gcgcccuccg uuacuacuau     1140

gacaagaaca ucaugaccaa gguccauggg aagcgcuacg ccuacaaguu cgacuuccac     1200

gggaucgccc aggcccucca gccccacccc ccggagucau cucuguacaa guaccccuca     1260

gaccucccgu acaugggcuc cuaucacgcc cacccacaga agaugaacuu uguggcgccc     1320

cacccuccag cccuccccgu gacaucuucc aguuuuuuug cugccccaaa cccauacugg     1380

aauucaccaa cuggggguau auaccccaac acuaggcucc ccaccagcca uaugccuucu     1440

caucugggca cuuacuacua a                                               1461


<210>  1471
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ERG__Homo_sapiens__CCDS46648.1

<400>  1471
augauccaga ccgugcccga cccggccgcc cacaucaagg aggcgcugag cgucgugucc       60

gaggaccaga gccucuucga gugcgccuac ggcacgcccc accuggccaa gaccgagaug      120

accgccucca gcuccagcga cuacgggcag accuccaaga ugagcccccg cgugccccag      180

caggacuggc ugucccagcc gcccgcccgg gucaccauca agauggagug caaccccagc      240

caggugaacg gcucccgcaa cagccccgac gagugcuccg uggcgaaggg cgggaagaug      300

gucgggagcc cggacacggu gggcaugaac uacggcuccu acauggagga gaagcacaug      360

cccccgccca acaugaccac caacgagcgg cgcgugaucg uccccgccga ccccacccuc      420

uggagcacgg accacgugcg gcaguggcug gagugggccg ugaaggagua cgggcugccc      480

gacgucaaca uccuccuguu ccagaacauc gacggcaagg agcugugcaa gaugaccaag      540

gacgacuucc agcgccucac ccccuccuac aacgccgaca uccugcugag ccaccuccac      600

uaccugcggg agaccccgcu gccccaccuc acguccgacg acguggacaa ggcgcugcag      660

aacagccccc gccugaugca cgcccggaac accgggggcg ccgccuucau cuuccccaac      720

accagcgugu acccggaggc cacccagcgc aucacgaccc ggcccgaccu ccccuacgag      780

cccccgcgcc gguccgcgug gaccgggcac ggccacccca cgccccagag caaggccgcc      840

cagcccuccc cgagcaccgu ccccaagacc gaggaccagc gcccccagcu ggacccguac      900

cagauccugg gccccaccuc cagccggcuc gccaaccccg gguccggcca gauccagcug      960

uggcaguucc ugcucgagcu gcugagcgac uccagcaacu ccagcugcau caccugggag     1020

gggacgaacg gcgaguucaa gaugaccgac cccgacgagg uggcccgccg guggggcgag     1080

cgcaagucca agccgaacau gaacuacgac aagcucagcc gggcgcugcg cuacuacuac     1140

gacaagaaca ucaugaccaa ggugcacggg aagcgguacg ccuacaaguu cgacuuccac     1200

ggcaucgccc aggcccugca gccccacccg cccgagucca gccucuacaa guaccccucc     1260

gaccugcccu acauggggag cuaccacgcc cacccccaga agaugaacuu cgucgcgccc     1320

cacccgcccg cccugcccgu gaccuccagc agcuucuucg ccgcccccaa cccguacugg     1380

aacuccccca cgggcgggau cuaccccaac acccgccucc ccaccagcca caugccgucc     1440

caccugggca ccuacuacug a                                               1461


<210>  1472
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ERG__Homo_sapiens__CCDS46648.1

<400>  1472
augauccaga ccguccccga ccccgccgcc cacaucaagg aggcccucuc cgucgucucc       60

gaggaccagu cccucuucga gugcgccuac ggcacccccc accucgccaa gaccgagaug      120

accgccuccu ccuccuccga cuacggccag accuccaaga uguccccccg cgucccccag      180

caggacuggc ucucccagcc ccccgcccgc gucaccauca agauggagug caaccccucc      240

caggucaacg gcucccgcaa cucccccgac gagugcuccg ucgccaaggg cggcaagaug      300

gucggcuccc ccgacaccgu cggcaugaac uacggcuccu acauggagga gaagcacaug      360

ccccccccca acaugaccac caacgagcgc cgcgucaucg uccccgccga ccccacccuc      420

ugguccaccg accacguccg ccaguggcuc gagugggccg ucaaggagua cggccucccc      480

gacgucaaca uccuccucuu ccagaacauc gacggcaagg agcucugcaa gaugaccaag      540

gacgacuucc agcgccucac ccccuccuac aacgccgaca uccuccucuc ccaccuccac      600

uaccuccgcg agaccccccu cccccaccuc accuccgacg acgucgacaa ggcccuccag      660

aacucccccc gccucaugca cgcccgcaac accggcggcg ccgccuucau cuuccccaac      720

accuccgucu accccgaggc cacccagcgc aucaccaccc gccccgaccu ccccuacgag      780

cccccccgcc gcuccgccug gaccggccac ggccacccca ccccccaguc caaggccgcc      840

cagcccuccc ccuccaccgu ccccaagacc gaggaccagc gcccccagcu cgaccccuac      900

cagauccucg gccccaccuc cucccgccuc gccaaccccg gcuccggcca gauccagcuc      960

uggcaguucc uccucgagcu ccucuccgac uccuccaacu ccuccugcau caccugggag     1020

ggcaccaacg gcgaguucaa gaugaccgac cccgacgagg ucgcccgccg cuggggcgag     1080

cgcaagucca agcccaacau gaacuacgac aagcucuccc gcgcccuccg cuacuacuac     1140

gacaagaaca ucaugaccaa gguccacggc aagcgcuacg ccuacaaguu cgacuuccac     1200

ggcaucgccc aggcccucca gccccacccc cccgaguccu cccucuacaa guaccccucc     1260

gaccuccccu acaugggcuc cuaccacgcc cacccccaga agaugaacuu cgucgccccc     1320

cacccccccg cccuccccgu caccuccucc uccuucuucg ccgcccccaa ccccuacugg     1380

aacuccccca ccggcggcau cuaccccaac acccgccucc ccaccuccca caugcccucc     1440

caccucggca ccuacuacug a                                               1461


<210>  1473
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ERG__Homo_sapiens__CCDS46648.1

<400>  1473
augauccaga ccgugcccga cccugccgcu cacauuaagg aggcacugag cgucguuucc       60

gaagaucaau cucucuucga gugcgccuac ggcacaccac aucuugcgaa aacugaaaug      120

acggcuucaa guagcuccga cuaugggcag accucuaaga ugucgccgag agugccccag      180

caggauuggc ugucacaacc uccagccagg guaacaauaa aaauggagug uaaccccagc      240

caggugaaug gaagucggaa cuccccugac gaaugcucug ucgcaaaggg uggcaaaaug      300

guggggagcc cagauacugu uggaaugaau uacggcuccu auauggagga gaagcacaug      360

cccccuccaa acaugaccac aaaugaacgc cgagugaucg ucccggccga ccccaccuug      420

uggucaacug aucaugugcg ucagugguua gagugggcug uaaaggaaua cggucugccu      480

gacguuaaca uucuacucuu ucagaauauc gaugggaaag agcuguguaa gaugacaaaa      540

gacgauuucc aaagacuuac cccaaguuau aacgcagaca uucuguugag ccaccuccau      600

uaccugaggg agacgccccu gccucaccuc acuucugaug acguggacaa ggccuuacaa      660

aauuccccac ggcugaugca cgcucgcaac accggaggcg ccgcguuuau cuuccccaau      720

acaucagucu auccggaagc aacucagaga auaaccacaa ggccugaucu ucccuacgag      780

ccaccucggc gcagcgccug gaccggccau gggcacccca cgccacagag uaaagcugcc      840

cagcccucuc cuuccacugu gccaaagaca gaagaccagc gaccgcaguu ggaucccuac      900

caaauccugg gaccuaccag cucgagacua gcaaacccag guucuggcca gauucagcuc      960

uggcaguuuc ugcuugagcu guuguccgac ucaaguaaua gcuccugcau cacuugggaa     1020

gggacaaacg gagaguucaa gaugaccgau cccgacgagg uggcuaggcg guggggcgaa     1080

cguaaaucua agccuaauau gaacuaugau aaacucagcc gcgcccugag auacuauuac     1140

gacaagaaca uuaugacgaa aguccauggu aagagguaug cguacaaauu ugauuuccac     1200

gggaucgccc aagcauuaca gccacauccc ccggagucaa gucuguauaa guacccuucc     1260

gaccucccau acaugggaag cuaucacgcu cacccccaga agaugaauuu uguugccccu     1320

caucccccag cccuuccugu gaccucuuca aguuucuuug cugcacccaa cccauacugg     1380

aauagcccga caggcggcau auauccuaac acucggcugc ccaccuccca caugccaucu     1440

cauuugggga cauacuauug a                                               1461


<210>  1474
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ERG__Homo_sapiens__CCDS46648.1

<400>  1474
augauccaga ccgugcccga ccccgccgcc cacaucaagg aggcccugag cguggugagc       60

gaggaccaga gccuguucga gugcgccuac ggcacccccc accuggccaa gaccgagaug      120

accgccagca gcagcagcga cuacggccag accagcaaga ugagccccag agugccccag      180

caggacuggc ugagccagcc ccccgccaga gugaccauca agauggagug caaccccagc      240

caggugaacg gcagcagaaa cagccccgac gagugcagcg uggccaaggg cggcaagaug      300

gugggcagcc ccgacaccgu gggcaugaac uacggcagcu acauggagga gaagcacaug      360

ccccccccca acaugaccac caacgagaga agagugaucg ugcccgccga ccccacccug      420

uggagcaccg accacgugag acaguggcug gagugggccg ugaaggagua cggccugccc      480

gacgugaaca uccugcuguu ccagaacauc gacggcaagg agcugugcaa gaugaccaag      540

gacgacuucc agagacugac ccccagcuac aacgccgaca uccugcugag ccaccugcac      600

uaccugagag agaccccccu gccccaccug accagcgacg acguggacaa ggcccugcag      660

aacagcccca gacugaugca cgccagaaac accggcggcg ccgccuucau cuuccccaac      720

accagcgugu accccgaggc cacccagaga aucaccacca gacccgaccu gcccuacgag      780

ccccccagaa gaagcgccug gaccggccac ggccacccca ccccccagag caaggccgcc      840

cagcccagcc ccagcaccgu gcccaagacc gaggaccaga gaccccagcu ggaccccuac      900

cagauccugg gccccaccag cagcagacug gccaaccccg gcagcggcca gauccagcug      960

uggcaguucc ugcuggagcu gcugagcgac agcagcaaca gcagcugcau caccugggag     1020

ggcaccaacg gcgaguucaa gaugaccgac cccgacgagg uggccagaag auggggcgag     1080

agaaagagca agcccaacau gaacuacgac aagcugagca gagcccugag auacuacuac     1140

gacaagaaca ucaugaccaa ggugcacggc aagagauacg ccuacaaguu cgacuuccac     1200

ggcaucgccc aggcccugca gccccacccc cccgagagca gccuguacaa guaccccagc     1260

gaccugcccu acaugggcag cuaccacgcc cacccccaga agaugaacuu cguggccccc     1320

cacccccccg cccugcccgu gaccagcagc agcuucuucg ccgcccccaa ccccuacugg     1380

aacagcccca ccggcggcau cuaccccaac accagacugc ccaccagcca caugcccagc     1440

caccugggca ccuacuacug a                                               1461


<210>  1475
<211>  1461
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ERG__Homo_sapiens__CCDS46648.1

<400>  1475
augauccaga ccgugcccga cccugccgcu cacauuaagg aggcccugag cgucguuucc       60

gaagaucaau cucucuucga gugcgcguac ggcacaccgc aucuggcuaa aacggaaaug      120

accgccagcu ccucuagcga cuaugggcag acauccaaga ugucucccag agugccucag      180

caggauuggc uuagccaacc cccugcccgg gugaccauca aaauggagug uaaccccucc      240

caggucaaug gaagccgcaa cucuccugac gaaugcuccg uggcuaaggg cgggaaaaug      300

guuggaagcc cggauacagu gggcaugaau uacgggucuu auauggagga gaagcacaug      360

cccccuccca acaugaccac aaaugaaaga cgggucauug ugccugccga ccccacccug      420

ugguccacgg aucauguucg ccaguggcuc gagugggcug ugaaggaaua cggacugccg      480

gacgucaaca uccuucuguu ucagaauauu gauggcaaag agcucuguaa gaugaccaaa      540

gacgauuucc aaagacugac accuagcuau aacgccgaca uccugcucuc ucaucugcac      600

uaccuucggg agacaccccu gccucaccuc accuccgaug acguggacaa ggcgcugcag      660

aauagccccc gccuuaugca cgccagaaac accggcgggg cugccuuuau cuuccccaau      720

acguccgugu auccugaagc uacacagcgg auuaccacac gcccggaucu gcccuacgag      780

ccucccagac ggucugccug gaccggacau ggccacccua caccccagag caaagcggcc      840

caaccguccc cuagcaccgu ccccaagacg gaagaccagc gcccucagcu cgaucccuac      900

caaauccugg ggccuaccuc uuccagacug gcuaaccccg gaagcggcca gauucagcuc      960

uggcaguuuc ugcuugagcu gcucucugac agcuccaauu cuagcugcau cacaugggaa     1020

gggaccaacg gagaguucaa gaugacagau ccggacgagg uugcccggcg cuggggcgaa     1080

agaaaaucca agccuaauau gaacuaugau aaacugagcc gggcucuuag auacuauuac     1140

gacaagaaca uuaugaccaa agugcauggc aagcgcuaug ccuacaaauu ugauuuccac     1200

gggaucgccc aagcucugca gccccauccc ccugagucuu cccucuauaa guacccgagc     1260

gaccugcccu acaugggauc uuaucacgcg cacccucaga agaugaauuu uguggcuccc     1320

cauccucccg cccugccugu cacguccagc uccuucuuug ccgcccccaa cccguacugg     1380

aacucuccua caggcgggau uuaucccaau acccggcucc cuaccagcca caugcccucc     1440

caucugggaa cauacuauug a                                               1461


<210>  1476
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ETV6__Homo_sapiens__P41212

<400>  1476

Met Ser Glu Thr Pro Ala Gln Cys Ser Ile Lys Gln Glu Arg Ile Ser 
1               5                   10                  15      


Tyr Thr Pro Pro Glu Ser Pro Val Pro Ser Tyr Ala Ser Ser Thr Pro 
            20                  25                  30          


Leu His Val Pro Val Pro Arg Ala Leu Arg Met Glu Glu Asp Ser Ile 
        35                  40                  45              


Arg Leu Pro Ala His Leu Arg Leu Gln Pro Ile Tyr Trp Ser Arg Asp 
    50                  55                  60                  


Asp Val Ala Gln Trp Leu Lys Trp Ala Glu Asn Glu Phe Ser Leu Arg 
65                  70                  75                  80  


Pro Ile Asp Ser Asn Thr Phe Glu Met Asn Gly Lys Ala Leu Leu Leu 
                85                  90                  95      


Leu Thr Lys Glu Asp Phe Arg Tyr Arg Ser Pro His Ser Gly Asp Val 
            100                 105                 110         


Leu Tyr Glu Leu Leu Gln His Ile Leu Lys Gln Arg Lys Pro Arg Ile 
        115                 120                 125             


Leu Phe Ser Pro Phe Phe His Pro Gly Asn Ser Ile His Thr Gln Pro 
    130                 135                 140                 


Glu Val Ile Leu His Gln Asn His Glu Glu Asp Asn Cys Val Gln Arg 
145                 150                 155                 160 


Thr Pro Arg Pro Ser Val Asp Asn Val His His Asn Pro Pro Thr Ile 
                165                 170                 175     


Glu Leu Leu His Arg Ser Arg Ser Pro Ile Thr Thr Asn His Arg Pro 
            180                 185                 190         


Ser Pro Asp Pro Glu Gln Arg Pro Leu Arg Ser Pro Leu Asp Asn Met 
        195                 200                 205             


Ile Arg Arg Leu Ser Pro Ala Glu Arg Ala Gln Gly Pro Arg Pro His 
    210                 215                 220                 


Gln Glu Asn Asn His Gln Glu Ser Tyr Pro Leu Ser Val Ser Pro Met 
225                 230                 235                 240 


Glu Asn Asn His Cys Pro Ala Ser Ser Glu Ser His Pro Lys Pro Ser 
                245                 250                 255     


Ser Pro Arg Gln Glu Ser Thr Arg Val Ile Gln Leu Met Pro Ser Pro 
            260                 265                 270         


Ile Met His Pro Leu Ile Leu Asn Pro Arg His Ser Val Asp Phe Lys 
        275                 280                 285             


Gln Ser Arg Leu Ser Glu Asp Gly Leu His Arg Glu Gly Lys Pro Ile 
    290                 295                 300                 


Asn Leu Ser His Arg Glu Asp Leu Ala Tyr Met Asn His Ile Met Val 
305                 310                 315                 320 


Ser Val Ser Pro Pro Glu Glu His Ala Met Pro Ile Gly Arg Ile Ala 
                325                 330                 335     


Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Ser Asp Ser 
            340                 345                 350         


Arg Tyr Glu Asn Phe Ile Arg Trp Glu Asp Lys Glu Ser Lys Ile Phe 
        355                 360                 365             


Arg Ile Val Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys 
    370                 375                 380                 


Asn Arg Thr Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His 
385                 390                 395                 400 


Tyr Tyr Lys Leu Asn Ile Ile Arg Lys Glu Pro Gly Gln Arg Leu Leu 
                405                 410                 415     


Phe Arg Phe Met Lys Thr Pro Asp Glu Ile Met Ser Gly Arg Thr Asp 
            420                 425                 430         


Arg Leu Glu His Leu Glu Ser Gln Glu Leu Asp Glu Gln Ile Tyr Gln 
        435                 440                 445             


Glu Asp Glu Cys 
    450         


<210>  1477
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ETV6__Homo_sapiens__AAA19786

<400>  1477
augucugaga cuccugcuca guguagcauu aagcaggaac gaauuucaua uacaccucca       60

gagagcccag ugccgaguua cgcuuccucg acgccacuuc auguuccagu gccucgagcg      120

cucaggaugg aggaagacuc gauccgccug ccugcgcacc ugcgcuugca gccaauuuac      180

uggagcaggg augacguagc ccaguggcuc aagugggcug aaaaugaguu uucuuuaagg      240

ccaauugaca gcaacacguu ugaaaugaau ggcaaagcuc uccugcugcu gaccaaagag      300

gacuuucgcu aucgaucucc ucauucaggu gaugugcucu augaacuccu ucagcauauu      360

cugaagcaga ggaaaccucg gauucuuuuu ucaccauucu uccacccugg aaacucuaua      420

cacacacagc cggaggucau acugcaucag aaccaugaag aagauaacug uguccagagg      480

acccccaggc cauccgugga uaaugugcac cauaacccuc ccaccauuga acuguugcac      540

cgcuccaggu caccuaucac gacaaaucac cggccuucuc cugaccccga gcagcggccc      600

cuccgguccc cccuggacaa caugauccgc cgccucuccc cggcugagag agcucaggga      660

cccaggccgc accaggagaa caaccaccag gaguccuacc cucugucagu gucucccaug      720

gagaauaauc acugcccagc guccuccgag ucccacccga agccauccag cccccggcag      780

gagagcacac gcgugaucca gcugaugccc agccccauca ugcacccucu gauccugaac      840

ccccggcacu ccguggauuu caaacagucc aggcucuccg aggacgggcu gcauagggaa      900

gggaagccca ucaaccucuc ucaucgggaa gaccuggcuu acaugaacca caucaugguc      960

ucugucuccc cgccugaaga gcacgccaug cccauuggga gaauagcaga cuguagacug     1020

cuuugggauu acgucuauca guugcuuucu gacagccggu acgaaaacuu cauccgaugg     1080

gaggacaaag aauccaaaau auuccggaua guggauccca acggacuggc ucgacugugg     1140

ggaaaccaua agaacagaac aaacaugacc uaugagaaaa uguccagagc ccugcgccac     1200

uacuacaaac uaaacauuau caggaaggag ccaggacaaa ggcuuuuguu cagguuuaug     1260

aaaaccccag augaaaucau gaguggccga acagaccguc uggagcaccu agagucccag     1320

gagcuggaug aacaaauaua ccaagaagau gaaugcuga                            1359


<210>  1478
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ETV6__Homo_sapiens__AAA19786

<400>  1478
augagcgaga cccccgccca gugcuccauc aagcaggagc gcaucagcua caccccgccc       60

gagucccccg ugcccagcua cgccuccagc acgccgcugc acguccccgu gccccgggcg      120

cuccgcaugg aggaggacuc cauccggcug cccgcccacc uccgccugca gccgaucuac      180

uggagccggg acgacguggc ccaguggcug aagugggccg agaacgaguu cucccugcgc      240

cccaucgaca gcaacaccuu cgagaugaac ggcaaggccc uccugcugcu caccaaggag      300

gacuuccggu accgcagccc ccacuccggg gacguccugu acgagcugcu ccagcacauc      360

cugaagcagc ggaagccccg cauccuguuc uccccguucu uccaccccgg caacagcauc      420

cacacccagc ccgaggugau ccuccaccag aaccacgagg aggacaacug cgugcagcgg      480

acgccccgcc cguccgucga caacgugcac cacaacccgc ccaccaucga gcugcugcac      540

cggagccgcu cccccaucac caccaaccac cggcccagcc ccgaccccga gcagcgcccc      600

cuccgguccc cgcuggacaa caugauccgc cggcugagcc ccgcggagcg cgcccagggg      660

ccccggcccc accaggagaa caaccaccag gagagcuacc cgcucuccgu gagccccaug      720

gagaacaacc acugccccgc cuccagcgag ucccacccga agcccagcag cccccgccag      780

gaguccacgc gcgucaucca gcugaugccc uccccgauca ugcacccccu gauccucaac      840

ccccggcaca gcguggacuu caagcagucc cgccugagcg aggacggccu gcaccgggag      900

gggaagccca ucaaccucuc ccaccgcgag gaccuggccu acaugaacca caucauggug      960

agcgucuccc cgcccgagga gcacgcgaug cccaucggcc ggaucgccga cugccgccug     1020

cucugggacu acguguacca gcugcugagc gacucccggu acgagaacuu cauccgcugg     1080

gaggacaagg agagcaagau cuuccggauc guggacccca acggccucgc ccgccugugg     1140

gggaaccaca agaaccggac caacaugacc uacgagaaga ugucccgcgc ccugcggcac     1200

uacuacaagc ucaacaucau ccgcaaggag ccgggccagc ggcugcuguu ccgcuucaug     1260

aagacccccg acgagaucau gagcgggcgg acggaccgcc ucgagcaccu ggagagccag     1320

gagcuggacg agcagaucua ccaggaggac gagugcuga                            1359


<210>  1479
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ETV6__Homo_sapiens__AAA19786

<400>  1479
auguccgaga cccccgccca gugcuccauc aagcaggagc gcaucuccua cacccccccc       60

gagucccccg uccccuccua cgccuccucc accccccucc acguccccgu cccccgcgcc      120

cuccgcaugg aggaggacuc cauccgccuc cccgcccacc uccgccucca gcccaucuac      180

uggucccgcg acgacgucgc ccaguggcuc aagugggccg agaacgaguu cucccuccgc      240

cccaucgacu ccaacaccuu cgagaugaac ggcaaggccc uccuccuccu caccaaggag      300

gacuuccgcu accgcucccc ccacuccggc gacguccucu acgagcuccu ccagcacauc      360

cucaagcagc gcaagccccg cauccucuuc ucccccuucu uccaccccgg caacuccauc      420

cacacccagc ccgaggucau ccuccaccag aaccacgagg aggacaacug cguccagcgc      480

accccccgcc ccuccgucga caacguccac cacaaccccc ccaccaucga gcuccuccac      540

cgcucccgcu cccccaucac caccaaccac cgccccuccc ccgaccccga gcagcgcccc      600

cuccgcuccc cccucgacaa caugauccgc cgccucuccc ccgccgagcg cgcccagggc      660

ccccgccccc accaggagaa caaccaccag gaguccuacc cccucuccgu cucccccaug      720

gagaacaacc acugccccgc cuccuccgag ucccacccca agcccuccuc cccccgccag      780

gaguccaccc gcgucaucca gcucaugccc ucccccauca ugcacccccu cauccucaac      840

ccccgccacu ccgucgacuu caagcagucc cgccucuccg aggacggccu ccaccgcgag      900

ggcaagccca ucaaccucuc ccaccgcgag gaccucgccu acaugaacca caucaugguc      960

uccgucuccc cccccgagga gcacgccaug cccaucggcc gcaucgccga cugccgccuc     1020

cucugggacu acgucuacca gcuccucucc gacucccgcu acgagaacuu cauccgcugg     1080

gaggacaagg aguccaagau cuuccgcauc gucgacccca acggccucgc ccgccucugg     1140

ggcaaccaca agaaccgcac caacaugacc uacgagaaga ugucccgcgc ccuccgccac     1200

uacuacaagc ucaacaucau ccgcaaggag cccggccagc gccuccucuu ccgcuucaug     1260

aagacccccg acgagaucau guccggccgc accgaccgcc ucgagcaccu cgagucccag     1320

gagcucgacg agcagaucua ccaggaggac gagugcuga                            1359


<210>  1480
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ETV6__Homo_sapiens__AAA19786

<400>  1480
augagcgaga cccccgccca gugcuccauc aagcaagaaa gaauuucuua cacaccucca       60

gagucaccgg ugcccaguua ugcuagcucc acuccucugc acgucccagu ucccagggca      120

cuccggaugg aagaggacuc uauacgccuu ccugcccauc ugcgauugca gccaaucuac      180

uggucgcgug augacguggc gcagugguua aaaugggcug aaaacgaguu cucacugaga      240

cccauugaua gcaauacguu ugagaugaac ggcaaggccc uacuccugcu uaccaaagaa      300

gacuucaggu aucggagucc ucacuccggg gauguacugu acgaguugcu ccagcauauc      360

cugaagcaac gcaaaccaag gauucuguuu ucuccguucu uucaccccgg aaauagcauc      420

cauacacagc cugaagugau acuccaccag aaccacgagg aggacaauug uguccagaga      480

acuccacggc ccuccgugga uaacguucau cacaauccuc caaccaucga auuacugcau      540

cgcucacgaa gucccauuac aaccaaccac agaccgagcc cugaccccga gcaaaggcca      600

cuucggucuc cuuuggauaa uaugauccgu cgccuguccc ccgcagaaag agcccagggu      660

ccaaggcccc accaggagaa caaucaucag gaaucauauc cucuaagcgu gaguccaaug      720

gagaacaauc acugcccggc uucuuccgag agccauccca agccuucguc uccacggcaa      780

gaauccacuc gagucauuca gcucaugccc ucaccuauca ugcacccacu gauacuuaac      840

ccccgccaua guguggacuu caagcagagc agacuguccg aggauggcuu gcacagggaa      900

gggaaaccga uuaaucucuc ucaccgggag gaccuggcau acaugaacca uaucauggua      960

agcguuucac cuccagaaga acacgccaug cccauuggac gcaucgcuga uuguagauua     1020

cugugggacu auguguacca acuccuuagu gacuccaggu acgagaacuu uauccguugg     1080

gaagauaagg agagcaaaau uuuccggaua gucgacccua auggccuggc ccgauugugg     1140

gguaaccaua agaauagaac aaacaugacc uaugagaaaa ugucuagggc gcuacgccac     1200

uacuauaagc ugaauaucau ucggaaggag cccgggcaga gacuccuguu uagguucaug     1260

aaaacgccag augaaaucau gucaggacgc acugaccgac uugagcaccu ggagagucag     1320

gaauuggaug agcagauaua ccaagaagac gagugcuga                            1359


<210>  1481
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ETV6__Homo_sapiens__AAA19786

<400>  1481
augagcgaga cccccgccca gugcagcauc aagcaggaga gaaucagcua cacccccccc       60

gagagccccg ugcccagcua cgccagcagc accccccugc acgugcccgu gcccagagcc      120

cugagaaugg aggaggacag caucagacug cccgcccacc ugagacugca gcccaucuac      180

uggagcagag acgacguggc ccaguggcug aagugggccg agaacgaguu cagccugaga      240

cccaucgaca gcaacaccuu cgagaugaac ggcaaggccc ugcugcugcu gaccaaggag      300

gacuucagau acagaagccc ccacagcggc gacgugcugu acgagcugcu gcagcacauc      360

cugaagcaga gaaagcccag aauccuguuc agccccuucu uccaccccgg caacagcauc      420

cacacccagc ccgaggugau ccugcaccag aaccacgagg aggacaacug cgugcagaga      480

acccccagac ccagcgugga caacgugcac cacaaccccc ccaccaucga gcugcugcac      540

agaagcagaa gccccaucac caccaaccac agacccagcc ccgaccccga gcagagaccc      600

cugagaagcc cccuggacaa caugaucaga agacugagcc ccgccgagag agcccagggc      660

cccagacccc accaggagaa caaccaccag gagagcuacc cccugagcgu gagccccaug      720

gagaacaacc acugccccgc cagcagcgag agccacccca agcccagcag ccccagacag      780

gagagcacca gagugaucca gcugaugccc agccccauca ugcacccccu gauccugaac      840

cccagacaca gcguggacuu caagcagagc agacugagcg aggacggccu gcacagagag      900

ggcaagccca ucaaccugag ccacagagag gaccuggccu acaugaacca caucauggug      960

agcgugagcc cccccgagga gcacgccaug cccaucggca gaaucgccga cugcagacug     1020

cugugggacu acguguacca gcugcugagc gacagcagau acgagaacuu caucagaugg     1080

gaggacaagg agagcaagau cuucagaauc guggacccca acggccuggc cagacugugg     1140

ggcaaccaca agaacagaac caacaugacc uacgagaaga ugagcagagc ccugagacac     1200

uacuacaagc ugaacaucau cagaaaggag cccggccaga gacugcuguu cagauucaug     1260

aagacccccg acgagaucau gagcggcaga accgacagac uggagcaccu ggagagccag     1320

gagcuggacg agcagaucua ccaggaggac gagugcuga                            1359


<210>  1482
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ETV6__Homo_sapiens__AAA19786

<400>  1482
augagcgaga cccccgccca gugcuccauc aagcaagaaa gaauuucuua cacaccuccg       60

gagagccccg ugccuuccua ugcuucuagc acgccccugc acgucccugu uccccgggcc      120

cuccgcaugg aagaggacuc caucagacug ccugcgcauc uucggcugca gccgauuuac      180

uggucucgcg augacguggc ucaguggcuc aaaugggccg aaaacgaguu cagccugaga      240

cccaucgauu ccaauaccuu ugagaugaac ggcaaggccc uucugcuccu gacaaaagaa      300

gacuuccggu aucgcagccc ucacucuggg gaugugcugu acgagcuccu gcagcauauu      360

cuuaagcaaa gaaaaccccg gauccuguuu uccccuuucu uucaccccgg aaauagcauc      420

cauacccagc cggaagucau ucuccaccag aaccacgagg aggacaauug ugugcagcgc      480

acaccuagac ccucuguuga uaacgugcau cacaauccuc ccaccaucga acugcuucau      540

cggucccgca gccccauuac aaccaaccac agaccuucuc cggaccccga gcaacggccu      600

cugcgcagcc cccucgauaa uaugaucaga cggcuguccc cugcugaaag agcccagggc      660

ccccgcccgc accaggagaa caaucaucag gaauccuauc cucugucugu cagccccaug      720

gagaacaauc acugcccugc uuccagcgag ucucauccca agccuuccag cccccggcaa      780

gaaucuacga gagugauuca gcucaugccg agcccuauca ugcacccccu gauucuuaac      840

ccccgccauu ccguugacuu caagcagucu cggcugagcg aggaugggcu ccacagagaa      900

ggaaaaccua ucaaucuguc ccaccgcgag gaccuugccu acaugaacca uaucauggug      960

agcgucucuc cgcccgaaga acacgcgaug ccuauuggcc ggaucgccga uuguagacug     1020

cucugggacu auguguacca acugcugucc gacagccgcu acgagaacuu uauucggugg     1080

gaagauaagg agucuaaaau cuucagaauu guggacccca augggcucgc ucgccugugg     1140

ggaaaccaua agaaucggac caacaugaca uaugagaaaa uguccagagc ccuucggcac     1200

uacuauaagc ugaauaucau ccgcaaggag ccuggccaga gacuccuguu ucgguucaug     1260

aaaacccccg augaaauuau gagcggcaga acagaccgcc uugagcaccu ggagucccag     1320

gaacucgaug agcagaucua ccaagaagac gagugcuga                            1359


<210>  1483
<211>  656
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EWS__Homo_sapiens__Q01844

<400>  1483

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro 
            260                 265                 270         


Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro 
        275                 280                 285             


Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg 
    290                 295                 300                 


Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly 
305                 310                 315                 320 


Arg Gly Gly Met Gly Ser Ala Gly Glu Arg Gly Gly Phe Asn Lys Pro 
                325                 330                 335     


Gly Gly Pro Met Asp Glu Gly Pro Asp Leu Asp Leu Gly Pro Pro Val 
            340                 345                 350         


Asp Pro Asp Glu Asp Ser Asp Asn Ser Ala Ile Tyr Val Gln Gly Leu 
        355                 360                 365             


Asn Asp Ser Val Thr Leu Asp Asp Leu Ala Asp Phe Phe Lys Gln Cys 
    370                 375                 380                 


Gly Val Val Lys Met Asn Lys Arg Thr Gly Gln Pro Met Ile His Ile 
385                 390                 395                 400 


Tyr Leu Asp Lys Glu Thr Gly Lys Pro Lys Gly Asp Ala Thr Val Ser 
                405                 410                 415     


Tyr Glu Asp Pro Pro Thr Ala Lys Ala Ala Val Glu Trp Phe Asp Gly 
            420                 425                 430         


Lys Asp Phe Gln Gly Ser Lys Leu Lys Val Ser Leu Ala Arg Lys Lys 
        435                 440                 445             


Pro Pro Met Asn Ser Met Arg Gly Gly Leu Pro Pro Arg Glu Gly Arg 
    450                 455                 460                 


Gly Met Pro Pro Pro Leu Arg Gly Gly Pro Gly Gly Pro Gly Gly Pro 
465                 470                 475                 480 


Gly Gly Pro Met Gly Arg Met Gly Gly Arg Gly Gly Asp Arg Gly Gly 
                485                 490                 495     


Phe Pro Pro Arg Gly Pro Arg Gly Ser Arg Gly Asn Pro Ser Gly Gly 
            500                 505                 510         


Gly Asn Val Gln His Arg Ala Gly Asp Trp Gln Cys Pro Asn Pro Gly 
        515                 520                 525             


Cys Gly Asn Gln Asn Phe Ala Trp Arg Thr Glu Cys Asn Gln Cys Lys 
    530                 535                 540                 


Ala Pro Lys Pro Glu Gly Phe Leu Pro Pro Pro Phe Pro Pro Pro Gly 
545                 550                 555                 560 


Gly Asp Arg Gly Arg Gly Gly Pro Gly Gly Met Arg Gly Gly Arg Gly 
                565                 570                 575     


Gly Leu Met Asp Arg Gly Gly Pro Gly Gly Met Phe Arg Gly Gly Arg 
            580                 585                 590         


Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Met Asp Arg Gly 
        595                 600                 605             


Gly Phe Gly Gly Gly Arg Arg Gly Gly Pro Gly Gly Pro Pro Gly Pro 
    610                 615                 620                 


Leu Met Glu Gln Met Gly Gly Arg Arg Gly Gly Arg Gly Gly Pro Gly 
625                 630                 635                 640 


Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg Pro Tyr 
                645                 650                 655     






<210>  1484
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EWS__Homo_sapiens__AAH04817

<400>  1484
auggcgucca cggauuacag uaccuauagc caagcugcag cgcagcaggg cuacagugcu       60

uacaccgccc agcccacuca aggauaugca cagaccaccc aggcauaugg gcaacaaagc      120

uauggaaccu auggacagcc cacugauguc agcuauaccc aggcucagac cacugcaacc      180

uaugggcaga ccgccuaugc aacuucuuau ggacagccuc ccacugguua uacuacucca      240

acugcccccc aggcauacag ccagccuguc cagggguaug gcacuggugc uuaugauacc      300

accacugcua cagucaccac cacccaggcc uccuaugcag cucagucugc auauggcacu      360

cagccugcuu auccagccua ugggcagcag ccagcagcca cugcaccuac aagaccgcag      420

gauggaaaca agcccacuga gacuagucaa ccucaaucua gcacaggggg uuacaaccag      480

cccagccuag gauauggaca gaguaacuac aguuaucccc agguaccugg gagcuacccc      540

augcagccag ucacugcacc uccauccuac ccuccuacca gcuauuccuc uacacagccg      600

acuaguuaug aucagagcag uuacucucag cagaacaccu augggcaacc gagcagcuau      660

ggacagcaga guagcuaugg ucaacaaagc agcuaugggc agcagccucc cacuaguuac      720

ccaccccaaa cuggauccua cagccaagcu ccaagucaau auagccaaca gagcagcagc      780

uacgggcagc agaguucauu ccgacaggac caccccagua gcaugggugu uuaugggcag      840

gagucuggag gauuuuccgg accaggagag aaccggagca ugaguggccc ugauaaccgg      900

ggcaggggaa gagggggauu ugaucgugga ggcaugagca gaggugggcg gggaggagga      960

cgcgguggaa ugggcagcgc uggagagcga gguggcuuca auaagccugg uggacccaug     1020

gaugaaggac cagaucuuga ucuaggccca ccuguagauc cagaugaaga cucugacaac     1080

agugcaauuu auguacaagg auuaaaugac agugugacuc uagaugaucu ggcagacuuc     1140

uuuaagcagu gugggguugu uaagaugaac aagagaacug ggcaacccau gauccacauc     1200

uaccuggaca aggaaacagg aaagcccaaa ggcgaugcca caguguccua ugaagaccca     1260

cccacugcca aggcugccgu ggaaugguuu gaugggaaag auuuucaagg gagcaaacuu     1320

aaagucuccc uugcucggaa gaagccucca augaacagua ugcggggugg ucugccaccc     1380

cgugagggca gaggcaugcc accaccacuc cguggagguc caggaggccc aggagguccu     1440

gggggaccca ugggucgcau gggaggccgu ggaggagaua gaggaggcuu cccuccaaga     1500

ggaccccggg guucccgagg gaaccccucu ggaggaggaa acguccagca ccgagcugga     1560

gacuggcagu gucccaaucc ggguugugga aaccagaacu ucgccuggag aacagagugc     1620

aaccagugua aggccccaaa gccugaaggc uuccucccgc cacccuuucc gcccccgggu     1680

ggugaucgug gcagaggugg cccugguggc augcggggag gaagaggugg ccucauggau     1740

cguggugguc ccgguggaau guucagaggu ggccguggug gagacagagg uggcuuccgu     1800

gguggccggg gcauggaccg agguggcuuu gguggaggaa gacgaggugg cccugggggg     1860

cccccuggac cuuugaugga acagauggga ggaagaagag gaggacgugg aggaccugga     1920

aaaauggaua aaggcgagca ccgucaggag cgcagagauc ggcccuacua g              1971


<210>  1485
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EWS__Homo_sapiens__AAH04817

<400>  1485
auggccagca ccgacuacuc caccuacagc caggccgcgg cccagcaggg cuacuccgcc       60

uacacggccc agcccaccca gggguacgcc cagaccaccc aggcguacgg ccagcagagc      120

uacgggacgu acggccagcc gaccgacgug uccuacaccc aggcccagac cacggccacc      180

uacgggcaga ccgccuacgc gaccagcuac ggccagcccc ccacgggcua caccaccccc      240

accgccccgc aggccuacuc ccagcccguc cagggguacg gcacgggggc cuacgacacc      300

accaccgcca cggugaccac cacccaggcg agcuacgccg cccaguccgc cuacggcacg      360

cagcccgccu accccgcgua cgggcagcag ccggccgcca ccgcccccac ccgcccccag      420

gacggcaaca agcccaccga gacgagccag ccgcagucca gcaccggcgg guacaaccag      480

cccucccugg gcuacgggca gagcaacuac uccuaccccc aggugcccgg cagcuacccg      540

augcagcccg ucaccgcccc ccccuccuac ccgcccacca gcuacuccag cacgcagccc      600

accagcuacg accaguccag cuacucccag cagaacaccu acggccagcc cagcuccuac      660

gggcagcaga gcuccuacgg ccagcagagc uccuacgggc agcagccgcc caccagcuac      720

cccccccaga cgggcuccua cagccaggcg ccgucccagu acagccagca guccagcucc      780

uacgggcagc agagcuccuu ccggcaggac caccccagca gcaugggcgu guacggccag      840

gaguccgggg gcuucagcgg gcccggcgag aaccgcucca ugagcgggcc ggacaaccgg      900

ggccgcggcc gggggggcuu cgaccgcggg ggcauguccc gggggggccg cggcgggggc      960

cgggggggca ugggcagcgc cggggagcgc ggcggguuca acaagcccgg cgggcccaug     1020

gacgagggcc ccgaccucga ccugggcccg cccguggacc ccgacgagga cuccgacaac     1080

agcgccaucu acguccaggg gcugaacgac uccgugaccc ucgacgaccu ggccgacuuc     1140

uucaagcagu gcggcguggu caagaugaac aagcggaccg ggcagcccau gauccacauc     1200

uaccuggaca aggagaccgg caagccgaag ggggacgcca ccgugagcua cgaggacccc     1260

cccacggcga aggccgccgu ggagugguuc gacggcaagg acuuccaggg cuccaagcuc     1320

aaggucagcc uggcccgcaa gaagcccccg augaacucca ugcggggggg ccugcccccc     1380

cgcgaggggc ggggcaugcc cccgccccuc cgcgggggcc ccggcgggcc cggcgggccg     1440

ggcgggccca ugggccggau gggcgggcgc ggcggggacc ggggcggcuu ccccccccgc     1500

gggccgcggg gcagccgcgg gaaccccucc ggcgggggca acgugcagca ccgcgcgggc     1560

gacuggcagu gccccaaccc ggggugcggc aaccagaacu ucgccuggcg gaccgagugc     1620

aaccagugca aggcccccaa gcccgagggg uuccugcccc cgcccuuccc ccccccgggc     1680

ggggaccgcg gccggggcgg gcccggcggg augcgcggcg ggcggggcgg ccugauggac     1740

cgcgggggcc ccgggggcau guuccggggc gggcgcggcg gggaccgggg cggguuccgc     1800

ggcggccggg ggauggaccg cggcggguuc ggcgggggcc ggcgcggcgg gcccggcggg     1860

ccgcccggcc cccucaugga gcagaugggg ggccggcgcg gcgggcgggg cgggcccggc     1920

aagauggaca agggggagca ccgccaggag cggcgcgacc gcccguacug a              1971


<210>  1486
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EWS__Homo_sapiens__AAH04817

<400>  1486
auggccucca ccgacuacuc caccuacucc caggccgccg cccagcaggg cuacuccgcc       60

uacaccgccc agcccaccca gggcuacgcc cagaccaccc aggccuacgg ccagcagucc      120

uacggcaccu acggccagcc caccgacguc uccuacaccc aggcccagac caccgccacc      180

uacggccaga ccgccuacgc caccuccuac ggccagcccc ccaccggcua caccaccccc      240

accgcccccc aggccuacuc ccagcccguc cagggcuacg gcaccggcgc cuacgacacc      300

accaccgcca ccgucaccac cacccaggcc uccuacgccg cccaguccgc cuacggcacc      360

cagcccgccu accccgccua cggccagcag cccgccgcca ccgcccccac ccgcccccag      420

gacggcaaca agcccaccga gaccucccag ccccaguccu ccaccggcgg cuacaaccag      480

cccucccucg gcuacggcca guccaacuac uccuaccccc agguccccgg cuccuacccc      540

augcagcccg ucaccgcccc ccccuccuac ccccccaccu ccuacuccuc cacccagccc      600

accuccuacg accaguccuc cuacucccag cagaacaccu acggccagcc cuccuccuac      660

ggccagcagu ccuccuacgg ccagcagucc uccuacggcc agcagccccc caccuccuac      720

cccccccaga ccggcuccua cucccaggcc cccucccagu acucccagca guccuccucc      780

uacggccagc aguccuccuu ccgccaggac caccccuccu ccaugggcgu cuacggccag      840

gaguccggcg gcuucuccgg ccccggcgag aaccgcucca uguccggccc cgacaaccgc      900

ggccgcggcc gcggcggcuu cgaccgcggc ggcauguccc gcggcggccg cggcggcggc      960

cgcggcggca ugggcuccgc cggcgagcgc ggcggcuuca acaagcccgg cggccccaug     1020

gacgagggcc ccgaccucga ccucggcccc cccgucgacc ccgacgagga cuccgacaac     1080

uccgccaucu acguccaggg ccucaacgac uccgucaccc ucgacgaccu cgccgacuuc     1140

uucaagcagu gcggcgucgu caagaugaac aagcgcaccg gccagcccau gauccacauc     1200

uaccucgaca aggagaccgg caagcccaag ggcgacgcca ccgucuccua cgaggacccc     1260

cccaccgcca aggccgccgu cgagugguuc gacggcaagg acuuccaggg cuccaagcuc     1320

aaggucuccc ucgcccgcaa gaagcccccc augaacucca ugcgcggcgg ccuccccccc     1380

cgcgagggcc gcggcaugcc ccccccccuc cgcggcggcc ccggcggccc cggcggcccc     1440

ggcggcccca ugggccgcau gggcggccgc ggcggcgacc gcggcggcuu ccccccccgc     1500

ggcccccgcg gcucccgcgg caaccccucc ggcggcggca acguccagca ccgcgccggc     1560

gacuggcagu gccccaaccc cggcugcggc aaccagaacu ucgccuggcg caccgagugc     1620

aaccagugca aggcccccaa gcccgagggc uuccuccccc cccccuuccc cccccccggc     1680

ggcgaccgcg gccgcggcgg ccccggcggc augcgcggcg gccgcggcgg ccucauggac     1740

cgcggcggcc ccggcggcau guuccgcggc ggccgcggcg gcgaccgcgg cggcuuccgc     1800

ggcggccgcg gcauggaccg cggcggcuuc ggcggcggcc gccgcggcgg ccccggcggc     1860

ccccccggcc cccucaugga gcagaugggc ggccgccgcg gcggccgcgg cggccccggc     1920

aagauggaca agggcgagca ccgccaggag cgccgcgacc gccccuacug a              1971


<210>  1487
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EWS__Homo_sapiens__AAH04817

<400>  1487
auggccagca ccgacuacuc cacauauucu caggcugcag cccaacaggg cuacucagcg       60

uauacugcuc agcccacgca gggguacgcc caaaccacac aggcauaugg acagcagagu      120

uacgguacuu auggccaacc uaccgaugug agcuacacac aggcccagac cacugcuaca      180

uacgggcaga ccgcauaugc cacguccuac ggacaaccac cgacuggcua uaccacaccc      240

acugcuccuc aggccuacuc ucagccaguc caagguuaug ggaccggagc guacgacaca      300

accacggcaa cuguuacaac cacucaggcc ucguaugcug cccagucagc auacggcaca      360

cagcccgcuu acccugccua uggccaacag ccagcggcca ccgcacccac gagaccucag      420

gaugggaaca agccaaccga gacaagccag ccgcaaaguu ccacuggagg uuacaaucag      480

cccucucugg gcuaugggca gagcaacuac uccuauccuc aggugccagg aucauacccc      540

augcaaccug uaaccgcucc acccaguuau ccgccuacaa gcuacucuuc cacucagccc      600

accucauacg accagagcag uuauucucag caaaauacau acggccagcc auccagcuau      660

ggucagcaau cgucuuacgg gcagcagucc ucauauggac agcaaccucc caccaguuac      720

ccaccccaga cuggcagcua uucccaggcc ccuucucagu acagccaaca gucaaguucc      780

uacggccagc agagcucuuu caggcaagau cacccaucaa guaugggggu guauggacag      840

gaaagcggug gcuuuuccgg gccgggagag aaccggucua ugucgggccc cgacaaucgc      900

ggucgagggc guggcggauu cgauagaggc gggaugagca ggggaggucg gggcggggga      960

cgcggcggua ugggguccgc uggcgaaaga ggaggcuuua acaaaccugg gggaccaaug     1020

gacgaggguc ccgaucucga ccuuggcccu ccagucgauc ccgacgaaga uucagacaau     1080

agugccaucu acgugcaggg gcugaacgac ucuguuacgu uggaugacuu agcagauuuc     1140

uuuaagcaau gcggaguggu caaaaugaau aagaggacag gccagccgau gauucauaua     1200

uaucuggaca aagagaccgg uaagccuaag ggggaugcca cugugagcua cgaggaccca     1260

cccaccgcua aagcggcagu agaaugguuc gauggcaagg acuuucaggg auccaaacua     1320

aagguuucac ucgcccggaa aaagccuccc augaacagca ugcgcggcgg gcugccaccu     1380

cgagagggaa gaggcaugcc cccaccgcuu aggggugggc cuggaggccc cgguggccca     1440

gggggaccca ugggccggau gggagggcgu ggcggugauc gcgggggauu cccuccaaga     1500

ggccccaggg guucucgggg caauccuucc gggggaggca acgugcagca ccgagcuggg     1560

gacuggcaau guccgaaucc aggaugcggc aaccagaauu uugccuggcg cacagaaugu     1620

aaccagugca aggcacccaa accugagggu uuccugccac ccccuuuucc gcccccaggg     1680

ggagauagag gcaggggugg cccuggggga augcggggcg ggcgcggagg cuugauggac     1740

agaggugggc ccggaggcau guucaggggc gggcguggag gugaccgggg cggguuucga     1800

ggaggcagag guauggaucg cgggggauuc ggcggcggga ggcggggagg uccaggcggg     1860

ccucccggac cacucaugga gcagaugggc gguagacgcg ggggaagggg cggcccgggg     1920

aagauggaca aaggagaaca ucgacaagag cggcgugaua gaccuuauug a              1971


<210>  1488
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EWS__Homo_sapiens__AAH04817

<400>  1488
auggccagca ccgacuacag caccuacagc caggccgccg cccagcaggg cuacagcgcc       60

uacaccgccc agcccaccca gggcuacgcc cagaccaccc aggccuacgg ccagcagagc      120

uacggcaccu acggccagcc caccgacgug agcuacaccc aggcccagac caccgccacc      180

uacggccaga ccgccuacgc caccagcuac ggccagcccc ccaccggcua caccaccccc      240

accgcccccc aggccuacag ccagcccgug cagggcuacg gcaccggcgc cuacgacacc      300

accaccgcca ccgugaccac cacccaggcc agcuacgccg cccagagcgc cuacggcacc      360

cagcccgccu accccgccua cggccagcag cccgccgcca ccgcccccac cagaccccag      420

gacggcaaca agcccaccga gaccagccag ccccagagca gcaccggcgg cuacaaccag      480

cccagccugg gcuacggcca gagcaacuac agcuaccccc aggugcccgg cagcuacccc      540

augcagcccg ugaccgcccc ccccagcuac ccccccacca gcuacagcag cacccagccc      600

accagcuacg accagagcag cuacagccag cagaacaccu acggccagcc cagcagcuac      660

ggccagcaga gcagcuacgg ccagcagagc agcuacggcc agcagccccc caccagcuac      720

cccccccaga ccggcagcua cagccaggcc cccagccagu acagccagca gagcagcagc      780

uacggccagc agagcagcuu cagacaggac caccccagca gcaugggcgu guacggccag      840

gagagcggcg gcuucagcgg ccccggcgag aacagaagca ugagcggccc cgacaacaga      900

ggcagaggca gaggcggcuu cgacagaggc ggcaugagca gaggcggcag aggcggcggc      960

agaggcggca ugggcagcgc cggcgagaga ggcggcuuca acaagcccgg cggccccaug     1020

gacgagggcc ccgaccugga ccugggcccc cccguggacc ccgacgagga cagcgacaac     1080

agcgccaucu acgugcaggg ccugaacgac agcgugaccc uggacgaccu ggccgacuuc     1140

uucaagcagu gcggcguggu gaagaugaac aagagaaccg gccagcccau gauccacauc     1200

uaccuggaca aggagaccgg caagcccaag ggcgacgcca ccgugagcua cgaggacccc     1260

cccaccgcca aggccgccgu ggagugguuc gacggcaagg acuuccaggg cagcaagcug     1320

aaggugagcc uggccagaaa gaagcccccc augaacagca ugagaggcgg ccugcccccc     1380

agagagggca gaggcaugcc ccccccccug agaggcggcc ccggcggccc cggcggcccc     1440

ggcggcccca ugggcagaau gggcggcaga ggcggcgaca gaggcggcuu cccccccaga     1500

ggccccagag gcagcagagg caaccccagc ggcggcggca acgugcagca cagagccggc     1560

gacuggcagu gccccaaccc cggcugcggc aaccagaacu ucgccuggag aaccgagugc     1620

aaccagugca aggcccccaa gcccgagggc uuccugcccc cccccuuccc cccccccggc     1680

ggcgacagag gcagaggcgg ccccggcggc augagaggcg gcagaggcgg ccugauggac     1740

agaggcggcc ccggcggcau guucagaggc ggcagaggcg gcgacagagg cggcuucaga     1800

ggcggcagag gcauggacag aggcggcuuc ggcggcggca gaagaggcgg ccccggcggc     1860

ccccccggcc cccugaugga gcagaugggc ggcagaagag gcggcagagg cggccccggc     1920

aagauggaca agggcgagca cagacaggag agaagagaca gacccuacug a              1971


<210>  1489
<211>  1971
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EWS__Homo_sapiens__AAH04817

<400>  1489
auggccagca ccgacuacuc cacauauucu caggcugccg cgcaacaggg cuacagcgcu       60

uauacggccc agcccaccca gggguacgcc caaacaaccc aggcuuaugg acagcagucc      120

uacggcacau augggcaacc uaccgaugug ucuuacacac aggcccagac cacggcuacc      180

uacggacaga cagccuaugc gaccagcuac ggccaaccgc ccacagggua uaccacgccu      240

acagcucccc aggccuacuc ccagccuguc caaggauaug gcaccggcgc cuacgacaca      300

accaccgcua caguuacgac cacacaggcc ucuuaugcgg cccagagcgc uuacgggacc      360

cagcccgccu acccugcuua uggacaacag ccggccgcca cagcucccac cagaccucag      420

gauggcaaca agcccacgga gacaucccag ccucaaagcu cuaccggggg auacaaucag      480

cccucccugg gcuaugggca gagcaacuac ucuuaucccc aggugccugg auccuacccc      540

augcaaccug ugaccgcgcc gcccagcuau ccuccgacau cuuacuccag cacccagccc      600

acauccuacg accagucuag cuauucccag caaaauacgu acggccagcc uagcucuuau      660

ggccagcaau ccagcuacgg gcagcagucu agcuauggac agcaaccccc uaccuccuau      720

cccccgcaga caggcucuua cagccaggcc ccuucccagu acagccaaca gucuuccagc      780

uacgggcagc agucuuccuu ccggcaagau caccccagcu ccaugggagu cuauggccag      840

gaaucugggg gauuuagcgg cccuggcgag aaccgcucca ugucugggcc cgacaauaga      900

ggacggggcc gcgggggauu cgauagaggc gggaugagcc ggggcggacg cggcggggga      960

agaggcggga ugggauccgc uggcgaaaga gggggcuuua acaaaccugg aggccccaug     1020

gacgaggggc cggaucucga ccugggaccu cccguggauc ccgacgaaga uagcgacaau     1080

ucugccaucu acguucaggg ccuuaacgac uccgugaccc uggaugaccu cgccgauuuc     1140

uuuaagcaau gcggggucgu gaaaaugaau aagcgcacag gacagccuau gauucauauc     1200

uaucuggaca aagagaccgg caagccgaag ggggaugcua cgguuagcua cgaggauccc     1260

ccuaccgcca aagcggcugu ggaaugguuc gacggcaagg acuuucaggg aucuaaacuu     1320

aaggucuccc uggcccggaa aaagcccccu augaacagca ugcggggcgg gcugcccccu     1380

cgcgagggaa gaggcaugcc cccgccucuc cgcgggggac ccggcgggcc uggcggaccc     1440

ggcgggccga ugggacggau gggcgggaga ggaggcgauc ggggcggguu cccucccaga     1500

ggaccucgcg gcucucgggg gaaucccagc ggaggcggga acgugcagca cagagccgga     1560

gacuggcaau gucccaaucc uggcugcggc aaccagaauu uugcuuggcg cacagaaugu     1620

aaccagugca aggccccgaa acccgagggg uuccugccuc ccccuuuucc cccuccggga     1680

ggcgaucggg ggagaggagg ccccggggga augcgcggcg gcagaggggg acucauggac     1740

cggggcgggc cuggaggcau guuccgcggg ggacggggcg gcgacagagg gggauuucgc     1800

ggcgggcggg gaauggauag aggcggguuc ggaggcggcc ggcgcggggg acccggcggg     1860

ccucccggac cgcugaugga gcagaugggc gggagacggg gaggcagagg cgggccugga     1920

aagauggaca aaggcgaaca ucgccaagag cggagagauc gccccuauug a              1971


<210>  1490
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__F2YMM1

<400>  1490

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly 
                85                  90                  95      


Asp Glu Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys 
            100                 105                 110         


Asn Tyr Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn 
        115                 120                 125             


Asp Glu Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp 
    130                 135                 140                 


Asp Asp Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys 
145                 150                 155                 160 


Gln Lys Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro 
                165                 170                 175     


Arg Lys Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe 
            180                 185                 190         


Pro Asp Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu 
        195                 200                 205             


Thr Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn 
    210                 215                 220                 


Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His 
225                 230                 235                 240 


Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe 
                245                 250                 255     


Leu His Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr 
            260                 265                 270         


Glu Thr Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His 
        275                 280                 285             


Leu Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile 
    290                 295                 300                 


Lys Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro 
305                 310                 315                 320 


Asn Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser 
                325                 330                 335     


Lys Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu 
            340                 345                 350         


Asn Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser 
        355                 360                 365             


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn 
    370                 375                 380                 


Ile Glu Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met 
385                 390                 395                 400 


Phe Arg Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala 
                405                 410                 415     


Arg Leu Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val 
            420                 425                 430         


Lys Glu Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr 
        435                 440                 445             


Pro Pro Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys 
    450                 455                 460                 


Arg Lys Ile Gln Leu Lys Lys Gly Gln Asn Arg Phe Pro Gly Cys Arg 
465                 470                 475                 480 


Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val 
                485                 490                 495     


Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp His 
            500                 505                 510         


Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly 
        515                 520                 525             


Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp Gly 
    530                 535                 540                 


Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr 
545                 550                 555                 560 


Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys Val 
                565                 570                 575     


Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe 
            580                 585                 590         


Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn His 
        595                 600                 605             


Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly Asp 
    610                 615                 620                 


His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu 
625                 630                 635                 640 


Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val 
                645                 650                 655     


Gly Ile Glu Arg Glu Met Glu Ile Pro 
            660                 665 


<210>  1491
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__AEA07595

<400>  1491
augggccaga cugggaagaa aucugagaag ggaccaguuu guuggcggaa gcguguaaaa       60

ucagaguaca ugcgacugag acagcucaag agguucagac gagcugauga aguaaagagu      120

auguuuaguu ccaaucguca gaaaauuuug gaaagaacgg aaaucuuaaa ccaagaaugg      180

aaacagcgaa ggauacagcc ugugcacauc cugacuucug ugagcucauu gcgcgggacu      240

agggaggugg aagaugaaac uguuuuacau aacauuccuu auaugggaga ugaaguuuua      300

gaucaggaug guacuuucau ugaagaacua auaaaaaauu augaugggaa aguacacggg      360

gauagagaau guggguuuau aaaugaugaa auuuuugugg aguuggugaa ugcccuuggu      420

caauauaaug augaugacga ugaugaugau ggagacgauc cugaagaaag agaagaaaag      480

cagaaagauc uggaggauca ccgagaugau aaagaaagcc gcccaccucg gaaauuuccu      540

ucugauaaaa uuuuugaagc cauuuccuca auguuuccag auaagggcac agcagaagaa      600

cuaaaggaaa aauauaaaga acucaccgaa cagcagcucc caggcgcacu uccuccugaa      660

uguaccccca acauagaugg accaaaugcu aaaucuguuc agagagagca aagcuuacac      720

uccuuucaua cgcuuuucug uaggcgaugu uuuaaauaug acugcuuccu acauccuuuu      780

caugcaacac ccaacacuua uaagcggaag aacacagaaa cagcucuaga caacaaaccu      840

uguggaccac aguguuacca gcauuuggag ggagcaaagg aguuugcugc ugcucucacc      900

gcugagcgga uaaagacccc accaaaacgu ccaggaggcc gcagaagagg acggcuuccc      960

aauaacagua gcaggcccag cacccccacc auuaaugugc uggaaucaaa ggauacagac     1020

agugauaggg aagcagggac ugaaacgggg ggagagaaca augauaaaga agaagaagag     1080

aagaaagaug aaacuucgag cuccucugaa gcaaauucuc ggugucaaac accaauaaag     1140

augaagccaa auauugaacc uccugagaau guggagugga guggugcuga agccucaaug     1200

uuuagagucc ucauuggcac uuacuaugac aauuucugug ccauugcuag guuaauuggg     1260

accaaaacau guagacaggu guaugaguuu agagucaaag aaucuagcau cauagcucca     1320

gcucccgcug aggaugugga uacuccucca aggaaaaaga agaggaaaca ccgguugugg     1380

gcugcacacu gcagaaagau acagcugaaa aagggucaaa accgcuuucc gggaugccgc     1440

ugcaaagcac agugcaacac caagcagugc ccgugcuacc uggcuguccg agagugugac     1500

ccugaccucu gucuuacuug uggagccgcu gaccauuggg acaguaaaaa uguguccugc     1560

aagaacugca guauucagcg gggcuccaaa aagcaucuau ugcuggcacc aucugacgug     1620

gcaggcuggg ggauuuuuau caaagauccu gugcagaaaa augaauucau cucagaauac     1680

uguggagaga uuauuucuca agaugaagcu gacagaagag ggaaagugua ugauaaauac     1740

augugcagcu uucuguucaa cuugaacaau gauuuugugg uggaugcaac ccgcaagggu     1800

aacaaaauuc guuuugcaaa ucauucggua aauccaaacu gcuaugcaaa aguuaugaug     1860

guuaacggug aucacaggau agguauuuuu gccaagagag ccauccagac uggcgaagag     1920

cuguuuuuug auuacagaua cagccaggcu gaugcccuga aguaugucgg caucgaaaga     1980

gaaauggaaa ucccuuga                                                   1998


<210>  1492
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EZH2__Homo_sapiens__AEA07595

<400>  1492
augggccaga ccgggaagaa guccgagaag ggccccgugu gcuggcgcaa gcgggucaag       60

agcgaguaca ugcgccugcg gcagcucaag cgcuuccggc gcgccgacga ggucaagagc      120

auguucucca gcaaccggca gaagauccug gagcgcaccg agauccugaa ccaggagugg      180

aagcagcggc gcauccagcc ggugcacauc cucacguccg ugagcucccu gcgggggacc      240

cgcgaggugg aggacgagac cgugcugcac aacauccccu acaugggcga cgagguccuc      300

gaccaggacg ggaccuucau cgaggagcug aucaagaacu acgacggcaa ggugcacggc      360

gaccgggagu gcggguucau caacgacgag aucuucgugg agcuggucaa cgcccucggc      420

caguacaacg acgacgacga cgacgacgac ggggacgacc ccgaggagcg cgaggagaag      480

cagaaggacc uggaggacca ccgggacgac aaggagagcc ggcccccgcg caaguucccc      540

uccgacaaga ucuucgaggc gaucagcucc auguuccccg acaagggcac ggccgaggag      600

cugaaggaga aguacaagga gcucaccgag cagcagcugc ccggggcccu gccgcccgag      660

ugcaccccca acaucgacgg ccccaacgcc aagagcgugc agcgcgagca gucccuccac      720

agcuuccaca cccuguucug ccggcgcugc uucaaguacg acugcuuccu gcacccguuc      780

cacgccacgc ccaacaccua caagcggaag aacaccgaga ccgcgcucga caacaagccc      840

ugcggccccc agugcuacca gcaccuggag ggggccaagg aguucgccgc cgcgcugacg      900

gccgagcgca ucaagacccc gcccaagcgc cccggcgggc ggcgccgggg ccgccucccc      960

aacaacucca gccggccguc cacccccacc aucaacgugc uggagagcaa ggacacggac     1020

uccgaccgcg aggccggcac cgagaccggg ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccagcag cuccagcgag gccaacuccc ggugccagac gcccaucaag     1140

augaagccca acaucgagcc gcccgagaac gucgagugga gcggggccga ggcguccaug     1200

uuccgcgugc ugaucggcac cuacuacgac aacuucugcg ccaucgcccg gcucaucggg     1260

accaagaccu gccgccaggu guacgaguuc cgggucaagg agagcuccau caucgccccc     1320

gcccccgcgg aggacgugga cacgccgccc cgcaagaaga agcggaagca ccgccugugg     1380

gccgcccacu gccggaagau ccagcugaag aagggccaga accgcuuccc cggcugccgg     1440

ugcaaggccc agugcaacac caagcagugc ccgugcuacc ucgccgugcg cgagugcgac     1500

cccgaccugu gccugaccug cggggcggcc gaccacuggg acagcaagaa cgucuccugc     1560

aagaacugca gcauccagcg gggcuccaag aagcaccucc ugcuggcccc cagcgacgug     1620

gccggguggg gcaucuucau caaggacccc gugcagaaga acgaguucau cuccgaguac     1680

ugcggggaga ucaucagcca ggacgaggcc gaccgccgcg gcaaggucua cgacaaguac     1740

augugcuccu uccucuucaa ccugaacaac gacuucgugg uggacgcgac ccggaagggc     1800

aacaagaucc gcuucgccaa ccacagcguc aacccgaacu gcuacgccaa ggugaugaug     1860

gucaacgggg accaccggau cggcaucuuc gccaagcgcg cgauccagac gggggaggag     1920

cuguucuucg acuaccggua cucccaggcc gacgcccuca aguacguggg caucgagcgc     1980

gagauggaga uccccuga                                                   1998


<210>  1493
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EZH2__Homo_sapiens__AEA07595

<400>  1493
augggccaga ccggcaagaa guccgagaag ggccccgucu gcuggcgcaa gcgcgucaag       60

uccgaguaca ugcgccuccg ccagcucaag cgcuuccgcc gcgccgacga ggucaagucc      120

auguucuccu ccaaccgcca gaagauccuc gagcgcaccg agauccucaa ccaggagugg      180

aagcagcgcc gcauccagcc cguccacauc cucaccuccg ucuccucccu ccgcggcacc      240

cgcgaggucg aggacgagac cguccuccac aacauccccu acaugggcga cgagguccuc      300

gaccaggacg gcaccuucau cgaggagcuc aucaagaacu acgacggcaa gguccacggc      360

gaccgcgagu gcggcuucau caacgacgag aucuucgucg agcucgucaa cgcccucggc      420

caguacaacg acgacgacga cgacgacgac ggcgacgacc ccgaggagcg cgaggagaag      480

cagaaggacc ucgaggacca ccgcgacgac aaggaguccc gccccccccg caaguucccc      540

uccgacaaga ucuucgaggc caucuccucc auguuccccg acaagggcac cgccgaggag      600

cucaaggaga aguacaagga gcucaccgag cagcagcucc ccggcgcccu cccccccgag      660

ugcaccccca acaucgacgg ccccaacgcc aaguccgucc agcgcgagca gucccuccac      720

uccuuccaca cccucuucug ccgccgcugc uucaaguacg acugcuuccu ccaccccuuc      780

cacgccaccc ccaacaccua caagcgcaag aacaccgaga ccgcccucga caacaagccc      840

ugcggccccc agugcuacca gcaccucgag ggcgccaagg aguucgccgc cgcccucacc      900

gccgagcgca ucaagacccc ccccaagcgc cccggcggcc gccgccgcgg ccgccucccc      960

aacaacuccu cccgccccuc cacccccacc aucaacgucc ucgaguccaa ggacaccgac     1020

uccgaccgcg aggccggcac cgagaccggc ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccuccuc cuccuccgag gccaacuccc gcugccagac ccccaucaag     1140

augaagccca acaucgagcc ccccgagaac gucgaguggu ccggcgccga ggccuccaug     1200

uuccgcgucc ucaucggcac cuacuacgac aacuucugcg ccaucgcccg ccucaucggc     1260

accaagaccu gccgccaggu cuacgaguuc cgcgucaagg aguccuccau caucgccccc     1320

gcccccgccg aggacgucga cacccccccc cgcaagaaga agcgcaagca ccgccucugg     1380

gccgcccacu gccgcaagau ccagcucaag aagggccaga accgcuuccc cggcugccgc     1440

ugcaaggccc agugcaacac caagcagugc cccugcuacc ucgccguccg cgagugcgac     1500

cccgaccucu gccucaccug cggcgccgcc gaccacuggg acuccaagaa cgucuccugc     1560

aagaacugcu ccauccagcg cggcuccaag aagcaccucc uccucgcccc cuccgacguc     1620

gccggcuggg gcaucuucau caaggacccc guccagaaga acgaguucau cuccgaguac     1680

ugcggcgaga ucaucuccca ggacgaggcc gaccgccgcg gcaaggucua cgacaaguac     1740

augugcuccu uccucuucaa ccucaacaac gacuucgucg ucgacgccac ccgcaagggc     1800

aacaagaucc gcuucgccaa ccacuccguc aaccccaacu gcuacgccaa ggucaugaug     1860

gucaacggcg accaccgcau cggcaucuuc gccaagcgcg ccauccagac cggcgaggag     1920

cucuucuucg acuaccgcua cucccaggcc gacgcccuca aguacgucgg caucgagcgc     1980

gagauggaga uccccuga                                                   1998


<210>  1494
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EZH2__Homo_sapiens__AEA07595

<400>  1494
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa aagggucaag       60

uccgaauaca ugcggcugcg ccaacucaaa cgauuccgua gagccgacga gguuaagucu      120

auguuuucaa guaacaggca gaagauccuu gaacggacag agauucugaa ucaggaaugg      180

aaacagcgca gaauacaacc ugugcacauc uugacuagcg uauccucuuu aagggguacg      240

cgggaggugg aggaugaaac cguccugcau aacauuccau auaugggcga cgaggugcua      300

gaucaggacg ggacauucau cgaagaacuc auuaagaauu acgauggaaa aguucacggc      360

gaccgcgagu gugguuuuau caacgaugaa auauucgugg agcuggucaa ugcucuuggg      420

caguauaacg acgaugacga ugacgaugac ggagacgauc cggaggagcg agaagagaag      480

cagaaagacc uggaggauca uagagacgau aaggaaucga ggcccccucg gaaguuucca      540

ucagacaaaa ucuucgaggc aauuagcagu auguuucccg auaagggcac ugccgaagag      600

uugaaagaaa aguacaaaga gcucaccgag caacagcugc cuggcgcgcu gccacccgaa      660

ugcacaccua auaucgacgg gccaaacgcu aaguccgugc agcgugagca gucucuccac      720

agcuuccaua ccuuauuuug ucgcagaugc uucaaauaug auuguuuucu gcacccguuc      780

cacgccacuc ccaauacaua caagaggaag aacaccgaaa cggcacuuga caauaaaccu      840

ugcggaccac aauguuauca gcauuuggag ggugccaagg aauuugcugc agcccugacu      900

gcugagcgga uuaaaacacc cccuaagcga ccaggcgggc gcagaagggg acggcuaccc      960

aacaauuccu cacgcccgag uaccccuacu aucaacguac ucgagagcaa agauaccgac     1020

ucugacagag aagccggcac agagaccggu ggggaaaaua acgauaagga ggaggaagag     1080

aagaaagacg aaacguccuc aagcagugag gcgaacucua ggugccagac ucccauaaag     1140

augaaaccaa auauugaacc ucccgagaac guugaguggu ccggagcaga agccagcaug     1200

uuccgugugc ugaucggcac auacuacgau aauuucugug cuauugcccg gcuuaucggc     1260

accaagacuu gccgacaagu cuaugaguuu agagugaaag aaucgucuau cauugcacca     1320

gcucccgccg aggacgugga uacaccucca aggaagaaga aacgcaagca ccggcugugg     1380

gcggcccauu guagaaaaau acaguugaag aaagggcaga acagguuccc gggaugccgc     1440

ugcaaggcac aguguaauac caagcaaugc cccuguuacc ucgcuguccg agaaugcgac     1500

ccugaucugu guuuaacgug cggugccgcu gaccacuggg auuccaaaaa cguuucaugu     1560

aagaauugca guauccagcg gggcagcaaa aagcaucugc uccuugcccc auccgacgug     1620

gcaggguggg gaauuuuuau caaagauccc guacagaaga acgaguucau aucugaguau     1680

uguggcgaaa uuaucagcca ggacgaggcc gaucguagag guaaagugua cgacaaguau     1740

augugcucau uucuguucaa uuugaacaau gacuuugucg uggaugcuac caggaagggg     1800

aacaaaaucc gcuucgcgaa ucacaguguu aacccuaauu guuacgcaaa ggugaugaug     1860

gucaacggcg accaccggau uggaaucuuu gccaaaagag cuauucaaac aggcgaggaa     1920

cuauucuuug auuauaggua cucccaggcc gacgcacuga aguacguggg gauagaacga     1980

gagauggaga ucccauga                                                   1998


<210>  1495
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EZH2__Homo_sapiens__AEA07595

<400>  1495
augggccaga ccggcaagaa gagcgagaag ggccccgugu gcuggagaaa gagagugaag       60

agcgaguaca ugagacugag acagcugaag agauucagaa gagccgacga ggugaagagc      120

auguucagca gcaacagaca gaagauccug gagagaaccg agauccugaa ccaggagugg      180

aagcagagaa gaauccagcc cgugcacauc cugaccagcg ugagcagccu gagaggcacc      240

agagaggugg aggacgagac cgugcugcac aacauccccu acaugggcga cgaggugcug      300

gaccaggacg gcaccuucau cgaggagcug aucaagaacu acgacggcaa ggugcacggc      360

gacagagagu gcggcuucau caacgacgag aucuucgugg agcuggugaa cgcccugggc      420

caguacaacg acgacgacga cgacgacgac ggcgacgacc ccgaggagag agaggagaag      480

cagaaggacc uggaggacca cagagacgac aaggagagca gaccccccag aaaguucccc      540

agcgacaaga ucuucgaggc caucagcagc auguuccccg acaagggcac cgccgaggag      600

cugaaggaga aguacaagga gcugaccgag cagcagcugc ccggcgcccu gccccccgag      660

ugcaccccca acaucgacgg ccccaacgcc aagagcgugc agagagagca gagccugcac      720

agcuuccaca cccuguucug cagaagaugc uucaaguacg acugcuuccu gcaccccuuc      780

cacgccaccc ccaacaccua caagagaaag aacaccgaga ccgcccugga caacaagccc      840

ugcggccccc agugcuacca gcaccuggag ggcgccaagg aguucgccgc cgcccugacc      900

gccgagagaa ucaagacccc ccccaagaga cccggcggca gaagaagagg cagacugccc      960

aacaacagca gcagacccag cacccccacc aucaacgugc uggagagcaa ggacaccgac     1020

agcgacagag aggccggcac cgagaccggc ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccagcag cagcagcgag gccaacagca gaugccagac ccccaucaag     1140

augaagccca acaucgagcc ccccgagaac guggagugga gcggcgccga ggccagcaug     1200

uucagagugc ugaucggcac cuacuacgac aacuucugcg ccaucgccag acugaucggc     1260

accaagaccu gcagacaggu guacgaguuc agagugaagg agagcagcau caucgccccc     1320

gcccccgccg aggacgugga cacccccccc agaaagaaga agagaaagca cagacugugg     1380

gccgcccacu gcagaaagau ccagcugaag aagggccaga acagauuccc cggcugcaga     1440

ugcaaggccc agugcaacac caagcagugc cccugcuacc uggccgugag agagugcgac     1500

cccgaccugu gccugaccug cggcgccgcc gaccacuggg acagcaagaa cgugagcugc     1560

aagaacugca gcauccagag aggcagcaag aagcaccugc ugcuggcccc cagcgacgug     1620

gccggcuggg gcaucuucau caaggacccc gugcagaaga acgaguucau cagcgaguac     1680

ugcggcgaga ucaucagcca ggacgaggcc gacagaagag gcaaggugua cgacaaguac     1740

augugcagcu uccuguucaa ccugaacaac gacuucgugg uggacgccac cagaaagggc     1800

aacaagauca gauucgccaa ccacagcgug aaccccaacu gcuacgccaa ggugaugaug     1860

gugaacggcg accacagaau cggcaucuuc gccaagagag ccauccagac cggcgaggag     1920

cuguucuucg acuacagaua cagccaggcc gacgcccuga aguacguggg caucgagaga     1980

gagauggaga uccccuga                                                   1998


<210>  1496
<211>  1998
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EZH2__Homo_sapiens__AEA07595

<400>  1496
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa acgggucaag       60

uccgaauaca ugcgccugag acaacucaaa cgguuccgca gagccgacga gguuaagucu      120

auguuuagcu ccaaccggca gaagauccug gaacgcacag agauucuuaa ucaggaaugg      180

aaacagagac ggauccaacc ugugcacauu cugacgucug ugagcucccu ccgcggcacc      240

agagaggucg aggaugaaac agugcugcau aacaucccgu auauggggga cgagguucuu      300

gaucaggacg gaaccuucau ugaagaacug aucaagaauu acgauggcaa agugcacggg      360

gaccgggagu guggauuuau caacgaugaa auuuucgucg agcucgugaa ugcucugggc      420

caguauaacg acgaugacga ugacgaugac ggcgacgauc ccgaagaacg cgaagagaag      480

cagaaagacc uggaggauca uagagacgau aaggaaucuc ggccuccccg caaguuuccu      540

agcgacaaaa ucuucgaggc cauuuccagc auguuucccg auaaggggac agcggaggag      600

cucaaagaaa aguacaaaga gcugaccgag caacagcuuc cuggagcucu gccgcccgaa      660

ugcacaccua auaucgacgg ccccaacgcc aagucuguuc agagagagca gucccuccac      720

agcuuccaua cccuguuuug ucggagaugc uucaaauaug auuguuuucu ucacccuuuc      780

cacgccacgc ccaauaccua caagcgcaag aacacagaaa ccgcucugga caauaaaccg      840

ugcgggccuc aauguuauca gcaucucgag ggagccaagg aauuugcugc cgcgcugaca      900

gccgagcgga uuaaaacgcc cccuaagaga cccggcgggc gccggagagg acgccugccc      960

aacaauucuu cccggccuag caccccgaca aucaacgugc ucgagucuaa agauaccgac     1020

uccgacagag aagcuggcac agagaccggc ggggaaaaua acgauaagga ggaggaagag     1080

aagaaagacg aaaccagcuc cucuagcgag gccaacuccc gcugccagac acccauuaag     1140

augaaaccua auaucgaacc cccugagaac gucgagugga gcggagcuga agccucuaug     1200

uuccgggugc ugaucggcac guacuacgau aauuucugug cgauugccag acuuaucggg     1260

accaagacau gccgccaagu guaugaguuu cgggucaaag aauccagcau uaucgcuccc     1320

gccccggcug aggacguuga uaccccuccc agaaagaaga aacggaagca ccgccugugg     1380

gccgcccauu guagaaaaau ucagcucaag aaaggacaga accgguuccc uggcugcaga     1440

ugcaaggcuc aguguaauac aaagcaaugc cccuguuacc uggcggugcg cgaaugcgac     1500

ccugaucuuu gucugaccug cggggccgcu gaccacuggg auucuaaaaa cgugagcugu     1560

aagaauugcu ccauccagcg gggaucuaaa aagcaccucc ugcuggcccc cagcgacguc     1620

gccggcuggg gcaucuuuau uaaagauccg gugcagaaga acgaguucau cuccgaguau     1680

uguggggaaa uuaucagcca ggacgaggcu gauagacgcg gaaaaguuua cgacaaguau     1740

augugcucuu uucucuucaa ucugaacaau gacuuugugg ucgaugccac gagaaagggc     1800

aacaaaauuc gguucgcgaa ucauuccgug aacccuaauu guuacgcuaa gguuaugaug     1860

gugaacgggg accaccgcau cggaaucuuu gccaaaagag ccauucaaac aggcgaggag     1920

cuuuucuuug auuaucggua cagccaggcu gacgcccuga aguacgucgg gaucgaacgc     1980

gagauggaga uucccuga                                                   1998


<210>  1497
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__G3XAL2

<400>  1497

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Pro Leu Leu Pro Arg Asn 
                325                 330                 


<210>  1498
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__EAW80068

<400>  1498
augggccaga cugggaagaa aucugagaag ggaccaguuu guuggcggaa gcguguaaaa       60

ucagaguaca ugcgacugag acagcucaag agguucagac gagcugauga aguaaagagu      120

auguuuaguu ccaaucguca gaaaauuuug gaaagaacgg aaaucuuaaa ccaagaaugg      180

aaacagcgaa ggauacagcc ugugcacauc cugacuucug ugagcucauu gcgcgggacu      240

agggaguguu cggugaccag ugacuuggau uuuccaacac aagucauccc auuaaagacu      300

cugaaugcag uugcuucagu acccauaaug uauucuuggu cuccccuaca gcagaauuuu      360

augguggaag augaaacugu uuuacauaac auuccuuaua ugggagauga aguuuuagau      420

caggauggua cuuucauuga agaacuaaua aaaaauuaug augggaaagu acacggggau      480

agagaaugug gguuuauaaa ugaugaaauu uuuguggagu uggugaaugc ccuuggucaa      540

uauaaugaug augacgauga ugaugaugga gacgauccug aagaaagaga agaaaagcag      600

aaagaucugg aggaucaccg agaugauaaa gaaagccgcc caccucggaa auuuccuucu      660

gauaaaauuu uugaagccau uuccucaaug uuuccagaua agggcacagc agaagaacua      720

aaggaaaaau auaaagaacu caccgaacag cagcucccag gcgcacuucc uccugaaugu      780

acccccaaca uagauggacc aaaugcuaaa ucuguucaga gagagcaaag cuuacacucc      840

uuucauacgc uuuucuguag gcgauguuuu aaauaugacu gcuuccuaca uccuuuucau      900

gcaacaccca acacuuauaa gcggaagaac acagaaacag cucuagacaa caaaccuugu      960

ggaccacagu guuaccagca uuugccacuc cuaccuagga acuaa                     1005


<210>  1499
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EZH2__Homo_sapiens__EAW80068

<400>  1499
augggccaga ccgggaagaa guccgagaag ggccccgugu gcuggcgcaa gcgggucaag       60

agcgaguaca ugcgccugcg gcagcucaag cgcuuccggc gcgccgacga ggucaagagc      120

auguucucca gcaaccggca gaagauccug gagcgcaccg agauccugaa ccaggagugg      180

aagcagcggc gcauccagcc ggugcacauc cucacguccg ugagcucccu gcgggggacc      240

cgcgagugca gcgugaccuc cgaccuggac uuccccaccc aggugauccc ccucaagacg      300

cugaacgccg ucgcgagcgu gcccaucaug uacuccugga gcccgcugca gcagaacuuc      360

augguggagg acgagaccgu ccuccacaac auccccuaca ugggcgacga ggugcuggac      420

caggacggga ccuucaucga ggagcugauc aagaacuacg acggcaaggu gcacggcgac      480

cgggagugcg gguucaucaa cgacgagauc uucgucgagc ucgugaacgc ccugggccag      540

uacaacgacg acgacgacga cgacgacggg gacgaccccg aggagcgcga ggagaagcag      600

aaggaccugg aggaccaccg ggacgacaag gagucccggc ccccgcgcaa guuccccagc      660

gacaagaucu ucgaggccau cuccagcaug uuccccgaca agggcaccgc cgaggagcuc      720

aaggagaagu acaaggagcu gacggagcag cagcugcccg gggcccuccc gcccgagugc      780

acccccaaca ucgacggccc caacgcgaag uccgugcagc gcgagcagag ccugcacucc      840

uuccacaccc uguucugccg gcgcugcuuc aaguacgacu gcuuccucca cccguuccac      900

gccaccccca acacguacaa gcggaagaac accgagaccg cccuggacaa caagcccugc      960

ggcccccagu gcuaccagca ccucccgcug cugccccgca acuga                     1005


<210>  1500
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EZH2__Homo_sapiens__EAW80068

<400>  1500
augggccaga ccggcaagaa guccgagaag ggccccgucu gcuggcgcaa gcgcgucaag       60

uccgaguaca ugcgccuccg ccagcucaag cgcuuccgcc gcgccgacga ggucaagucc      120

auguucuccu ccaaccgcca gaagauccuc gagcgcaccg agauccucaa ccaggagugg      180

aagcagcgcc gcauccagcc cguccacauc cucaccuccg ucuccucccu ccgcggcacc      240

cgcgagugcu ccgucaccuc cgaccucgac uuccccaccc aggucauccc ccucaagacc      300

cucaacgccg ucgccuccgu ccccaucaug uacuccuggu ccccccucca gcagaacuuc      360

auggucgagg acgagaccgu ccuccacaac auccccuaca ugggcgacga gguccucgac      420

caggacggca ccuucaucga ggagcucauc aagaacuacg acggcaaggu ccacggcgac      480

cgcgagugcg gcuucaucaa cgacgagauc uucgucgagc ucgucaacgc ccucggccag      540

uacaacgacg acgacgacga cgacgacggc gacgaccccg aggagcgcga ggagaagcag      600

aaggaccucg aggaccaccg cgacgacaag gagucccgcc ccccccgcaa guuccccucc      660

gacaagaucu ucgaggccau cuccuccaug uuccccgaca agggcaccgc cgaggagcuc      720

aaggagaagu acaaggagcu caccgagcag cagcuccccg gcgcccuccc ccccgagugc      780

acccccaaca ucgacggccc caacgccaag uccguccagc gcgagcaguc ccuccacucc      840

uuccacaccc ucuucugccg ccgcugcuuc aaguacgacu gcuuccucca ccccuuccac      900

gccaccccca acaccuacaa gcgcaagaac accgagaccg cccucgacaa caagcccugc      960

ggcccccagu gcuaccagca ccucccccuc cucccccgca acuga                     1005


<210>  1501
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EZH2__Homo_sapiens__EAW80068

<400>  1501
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa aagggucaag       60

uccgaauaca ugcggcugcg ccaacucaaa cgauuccgua gagccgacga gguuaagucu      120

auguuuucaa guaacaggca gaagauccuu gaacggacag agauucugaa ucaggaaugg      180

aaacagcgca gaauacaacc ugugcacauc uugacuagcg uauccucuuu aagggguacg      240

cgggaguguu cggugaccuc agaucuggac uucccaacac aggucauucc gcuaaagacu      300

cucaacgcug uggcaagcgu ucccaucaug uauaguuggu ccccucugca gcagaauuuu      360

augguggagg augaaaccgu ccuucauaac auuccauaca ugggcgacga ggugcuggau      420

caagacggga cauucaucga agaguugauc aaaaauuaug auggaaaggu acacggcgac      480

cgcgagugcg guuuuauaaa cgaugaaauu uucguugagc ucgugaaugc ccuggggcag      540

uacaacgacg augacgauga cgacgaugga gacgaucccg aagaacgaga agagaaacag      600

aaggaccugg aggaucauag agacgauaag gaaucuaggc cuccacggaa auuucccagc      660

gacaagaucu ucgaggcgau uuccucaaug uuuccugaua aaggcaccgc ugaggagcuc      720

aaggaaaaau auaaggaguu aacugagcag caacugccag gcgcccuucc gcccgaaugu      780

acaccuaaua ucgacgggcc aaacgcaaaa aguguccagc gugagcagag cuugcacucu      840

uuccauaccc uguuuugccg cagauguuuc aaguacgauu gcuuucuaca ccccuuccac      900

gccacgccua auacuuauaa gaggaaaaac accgaaacag cucucgacaa uaagccaugu      960

ggaccccaau gcuaccagca ucugccgcuu cugccucgga acuga                     1005


<210>  1502
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EZH2__Homo_sapiens__EAW80068

<400>  1502
augggccaga ccggcaagaa gagcgagaag ggccccgugu gcuggagaaa gagagugaag       60

agcgaguaca ugagacugag acagcugaag agauucagaa gagccgacga ggugaagagc      120

auguucagca gcaacagaca gaagauccug gagagaaccg agauccugaa ccaggagugg      180

aagcagagaa gaauccagcc cgugcacauc cugaccagcg ugagcagccu gagaggcacc      240

agagagugca gcgugaccag cgaccuggac uuccccaccc aggugauccc ccugaagacc      300

cugaacgccg uggccagcgu gcccaucaug uacagcugga gcccccugca gcagaacuuc      360

augguggagg acgagaccgu gcugcacaac auccccuaca ugggcgacga ggugcuggac      420

caggacggca ccuucaucga ggagcugauc aagaacuacg acggcaaggu gcacggcgac      480

agagagugcg gcuucaucaa cgacgagauc uucguggagc uggugaacgc ccugggccag      540

uacaacgacg acgacgacga cgacgacggc gacgaccccg aggagagaga ggagaagcag      600

aaggaccugg aggaccacag agacgacaag gagagcagac cccccagaaa guuccccagc      660

gacaagaucu ucgaggccau cagcagcaug uuccccgaca agggcaccgc cgaggagcug      720

aaggagaagu acaaggagcu gaccgagcag cagcugcccg gcgcccugcc ccccgagugc      780

acccccaaca ucgacggccc caacgccaag agcgugcaga gagagcagag ccugcacagc      840

uuccacaccc uguucugcag aagaugcuuc aaguacgacu gcuuccugca ccccuuccac      900

gccaccccca acaccuacaa gagaaagaac accgagaccg cccuggacaa caagcccugc      960

ggcccccagu gcuaccagca ccugccccug cugcccagaa acuga                     1005


<210>  1503
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EZH2__Homo_sapiens__EAW80068

<400>  1503
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa acgggucaag       60

uccgaauaca ugcgccugag acaacucaaa cgguuccgca gagccgacga gguuaagucu      120

auguuuagcu ccaaccggca gaagauccug gaacgcacag agauucuuaa ucaggaaugg      180

aaacagagac ggauccaacc ugugcacauu cugacgucug ugagcucccu ccgcggcacc      240

agagaguguu cugucacaag cgaucuggac uucccgaccc aggugauccc ccuuaagaca      300

cugaacgcug uugccuccgu gccuauuaug uauagcuggu cuccccucca gcagaauuuu      360

auggucgagg augaaaccgu gcugcauaac aucccuuaca ugggggacga gguucuggau      420

caagacggaa cauucaucga agaacucauu aaaaauuaug auggcaaggu gcacggggac      480

cgggagugcg gauuuaucaa cgaugaaauu uucgucgagc uggugaaugc gcuuggccag      540

uacaacgacg augacgauga cgacgauggc gacgaucccg aggagcgcga agagaaacag      600

aaggaccugg aggaucauag agacgauaag gaaucccggc cuccgcgcaa auuucccagc      660

gacaagaucu ucgaggcuau uucuuccaug uuuccugaua aagggaccgc cgaggaacuc      720

aaggaaaaau auaaggagcu gacggagcag caacuucccg gagcccugcc ucccgaaugu      780

accccgaaua ucgacggccc uaacgcuaaa agcgugcaga gagagcaguc ucuccacucc      840

uuccauacac uguuuugccg gagauguuuc aaguacgauu gcuuucugca ccccuuccac      900

gccaccccua auacauauaa gcgcaaaaac accgaaacgg cucucgacaa uaagcccugu      960

gggccccaau gcuaccagca ucugccucuu cugccgcgga acuga                     1005


<210>  1504
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__L0R855

<400>  1504

Met Pro Leu Val Asn Ile Met Met Met Thr Met Met Met Met Glu Thr 
1               5                   10                  15      


Ile Leu Lys Lys Glu Lys Lys Ser Arg Lys Ile Trp Arg Ile Thr Glu 
            20                  25                  30          


Met Ile Lys Lys Ala Ala His Leu Gly Asn Phe Leu Leu Ile Lys Phe 
        35                  40                  45              


Leu Lys Pro Phe Pro Gln Cys Phe Gln Ile Arg Ala Gln Gln Lys Asn 
    50                  55                  60                  






<210>  1505
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__CCO13726

<400>  1505
augcccuugg ucaauauaau gaugaugacg augaugauga uggagacgau ccugaagaaa       60

gagaagaaaa gcagaaagau cuggaggauc accgagauga uaaagaaagc cgcccaccuc      120

ggaaauuucc uucugauaaa auuuuugaag ccauuuccuc aauguuucca gauaagggca      180

cagcagaaga acuaa                                                       195


<210>  1506
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EZH2__Homo_sapiens__CCO13726

<400>  1506
augccccugg ugaacaucau gaugaugacc augaugauga uggagaccau ccucaagaag       60

gagaagaaga gccgcaagau cuggcggauc acggagauga ucaagaaggc cgcccaccug      120

ggcaacuucc ugcucaucaa guuccugaag ccguuccccc agugcuucca gauccgcgcg      180

cagcagaaga acuga                                                       195


<210>  1507
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EZH2__Homo_sapiens__CCO13726

<400>  1507
augccccucg ucaacaucau gaugaugacc augaugauga uggagaccau ccucaagaag       60

gagaagaagu cccgcaagau cuggcgcauc accgagauga ucaagaaggc cgcccaccuc      120

ggcaacuucc uccucaucaa guuccucaag cccuuccccc agugcuucca gauccgcgcc      180

cagcagaaga acuga                                                       195


<210>  1508
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EZH2__Homo_sapiens__CCO13726

<400>  1508
augccccugg ugaacaucau gaugaugacc augaugauga uggagacaau ucucaagaaa       60

gaaaagaaaa gcagaaagau auggaggauc acugagauga uuaaaaaggc cgcucaccuu      120

ggcaauuucc uguugaucaa guuuuuaaaa ccuuucccac agugcuuuca aauucgggca      180

cagcagaaga acuga                                                       195


<210>  1509
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EZH2__Homo_sapiens__CCO13726

<400>  1509
augccccugg ugaacaucau gaugaugacc augaugauga uggagaccau ccugaagaag       60

gagaagaaga gcagaaagau cuggagaauc accgagauga ucaagaaggc cgcccaccug      120

ggcaacuucc ugcugaucaa guuccugaag cccuuccccc agugcuucca gaucagagcc      180

cagcagaaga acuga                                                       195


<210>  1510
<211>  195
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EZH2__Homo_sapiens__CCO13726

<400>  1510
augccccugg ugaacaucau gaugaugacc augaugauga uggagacaau ucucaagaaa       60

gaaaagaaaa gcagaaagau cuggcggauu acggagauga ucaaaaaggc cgcucaccug      120

ggcaauuucc uucugauuaa guuucucaaa ccuuucccgc agugcuuuca aauccgcgcc      180

cagcagaaga acuga                                                       195


<210>  1511
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__Q15910

<400>  1511

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  1512
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__AAC51520

<400>  1512
augggccaga cugggaagaa aucugagaag ggaccaguuu guuggcggaa gcguguaaaa       60

ucagaguaca ugcgacugag acagcucaag agguucagac gagcugauga aguaaagagu      120

auguuuaguu ccaaucguca gaaaauuuug gaaagaacgg aaaucuuaaa ccaagaaugg      180

aaacagcgaa ggauacagcc ugugcacauc cugacuucug ugagcucauu gcgcgggacu      240

agggaguguu cggugaccag ugacuuggau uuuccaacac aagucauccc auuaaagacu      300

cugaaugcag uugcuucagu acccauaaug uauucuuggu cuccccuaca gcagaauuuu      360

augguggaag augaaacugu uuuacauaac auuccuuaua ugggagauga aguuuuagau      420

caggauggua cuuucauuga agaacuaaua aaaaauuaug augggaaagu acacggggau      480

agagaaugug gguuuauaaa ugaugaaauu uuuguggagu uggugaaugc ccuuggucaa      540

uauaaugaug augacgauga ugaugaugga gacgauccug aagaaagaga agaaaagcag      600

aaagaucugg aggaucaccg agaugauaaa gaaagccgcc caccucggaa auuuccuucu      660

gauaaaauuu uugaagccau uuccucaaug uuuccagaua agggcacagc agaagaacua      720

aaggaaaaau auaaagaacu caccgaacag cagcucccag gcgcacuucc uccugaaugu      780

acccccaaca uagauggacc aaaugcuaaa ucuguucaga gagagcaaag cuuacacucc      840

uuucauacgc uuuucuguag gcgauguuuu aaauaugacu gcuuccuaca uccuuuucau      900

gcaacaccca acacuuauaa gcggaagaac acagaaacag cucuagacaa caaaccuugu      960

ggaccacagu guuaccagca uuuggaggga gcaaaggagu uugcugcugc ucucaccgcu     1020

gagcggauaa agaccccacc aaaacgucca ggaggccgca gaagaggacg gcuucccaau     1080

aacaguagca ggcccagcac ccccaccauu aaugugcugg aaucaaagga uacagacagu     1140

gauagggaag cagggacuga aacgggggga gagaacaaug auaaagaaga agaagagaag     1200

aaagaugaaa cuucgagcuc cucugaagca aauucucggu gucaaacacc aauaaagaug     1260

aagccaaaua uugaaccucc ugagaaugug gaguggagug gugcugaagc cucaauguuu     1320

agaguccuca uuggcacuua cuaugacaau uucugugcca uugcuagguu aauugggacc     1380

aaaacaugua gacaggugua ugaguuuaga gucaaagaau cuagcaucau agcuccagcu     1440

cccgcugagg auguggauac uccuccaagg aaaaagaaga ggaaacaccg guugugggcu     1500

gcacacugca gaaagauaca gcugaaaaag gacggcuccu cuaaccaugu uuacaacuau     1560

caacccugug aucauccacg gcagccuugu gacaguucgu gcccuugugu gauagcacaa     1620

aauuuuugug aaaaguuuug ucaauguagu ucagaguguc aaaaccgcuu uccgggaugc     1680

cgcugcaaag cacagugcaa caccaagcag ugcccgugcu accuggcugu ccgagagugu     1740

gacccugacc ucugucuuac uuguggagcc gcugaccauu gggacaguaa aaaugugucc     1800

ugcaagaacu gcaguauuca gcggggcucc aaaaagcauc uauugcuggc accaucugac     1860

guggcaggcu gggggauuuu uaucaaagau ccugugcaga aaaaugaauu caucucagaa     1920

uacuguggag agauuauuuc ucaagaugaa gcugacagaa gagggaaagu guaugauaaa     1980

uacaugugca gcuuucuguu caacuugaac aaugauuuug ugguggaugc aacccgcaag     2040

gguaacaaaa uucguuuugc aaaucauucg guaaauccaa acugcuaugc aaaaguuaug     2100

augguuaacg gugaucacag gauagguauu uuugccaaga gagccaucca gacuggcgaa     2160

gagcuguuuu uugauuacag auacagccag gcugaugccc ugaaguaugu cggcaucgaa     2220

agagaaaugg aaaucccuug a                                               2241


<210>  1513
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EZH2__Homo_sapiens__AAC51520

<400>  1513
augggccaga ccgggaagaa guccgagaag ggccccgugu gcuggcgcaa gcgggucaag       60

agcgaguaca ugcgccugcg gcagcucaag cgcuuccggc gcgccgacga ggucaagagc      120

auguucucca gcaaccggca gaagauccug gagcgcaccg agauccugaa ccaggagugg      180

aagcagcggc gcauccagcc ggugcacauc cucacguccg ugagcucccu gcgggggacc      240

cgcgagugca gcgugaccuc cgaccuggac uuccccaccc aggugauccc ccucaagacg      300

cugaacgccg ucgcgagcgu gcccaucaug uacuccugga gcccgcugca gcagaacuuc      360

augguggagg acgagaccgu ccuccacaac auccccuaca ugggcgacga ggugcuggac      420

caggacggga ccuucaucga ggagcugauc aagaacuacg acggcaaggu gcacggcgac      480

cgggagugcg gguucaucaa cgacgagauc uucgucgagc ucgugaacgc ccugggccag      540

uacaacgacg acgacgacga cgacgacggg gacgaccccg aggagcgcga ggagaagcag      600

aaggaccugg aggaccaccg ggacgacaag gagucccggc ccccgcgcaa guuccccagc      660

gacaagaucu ucgaggccau cuccagcaug uuccccgaca agggcaccgc cgaggagcuc      720

aaggagaagu acaaggagcu gacggagcag cagcugcccg gggcccuccc gcccgagugc      780

acccccaaca ucgacggccc caacgcgaag uccgugcagc gcgagcagag ccugcacucc      840

uuccacaccc uguucugccg gcgcugcuuc aaguacgacu gcuuccucca cccguuccac      900

gccaccccca acacguacaa gcggaagaac accgagaccg cccuggacaa caagcccugc      960

ggcccccagu gcuaccagca ccuggagggg gccaaggagu ucgcggccgc ccucaccgcc     1020

gagcgcauca agacgccgcc caagcgcccc ggcgggcggc gccggggccg ccugcccaac     1080

aacagcagcc ggccguccac ccccaccauc aacguccugg agagcaagga caccgacucc     1140

gaccgcgagg ccggcacgga gaccgggggc gagaacaacg acaaggagga ggaggagaag     1200

aaggacgaga ccagcuccag cuccgaggcg aacagccggu gccagacccc caucaagaug     1260

aagcccaaca ucgagccgcc cgagaacgug gagugguccg gggccgaggc cagcauguuc     1320

cgcgugcuca ucggcacgua cuacgacaac uucugcgcca ucgcccggcu gaucgggacc     1380

aagaccugcc gccaggucua cgaguuccgg gugaaggagu ccagcaucau cgcgcccgcc     1440

ccggccgagg acguggacac cccgccccgc aagaagaagc ggaagcaccg ccugugggcc     1500

gcccacugcc ggaagaucca gcucaagaag gacggcucca gcaaccacgu cuacaacuac     1560

cagcccugcg accacccccg ccagcccugc gacuccagcu gccccugcgu gaucgcgcag     1620

aacuucugcg agaaguucug ccagugcucc agcgagugcc agaaccgguu ccccggcugc     1680

cgcugcaagg cccagugcaa cacgaagcag ugcccgugcu accuggccgu gcgggagugc     1740

gaccccgacc ugugccugac cugcggggcc gccgaccacu gggacuccaa gaacgucagc     1800

ugcaagaacu gcagcaucca gcgcggcucc aagaagcacc uccugcucgc gcccagcgac     1860

guggccgggu ggggcaucuu caucaaggac cccguccaga agaacgaguu caucuccgag     1920

uacugcgggg agaucaucag ccaggacgag gccgaccgcc ggggcaaggu guacgacaag     1980

uacaugugcu ccuuccuguu caaccugaac aacgacuucg uggucgacgc cacccgcaag     2040

ggcaacaaga uccgguucgc gaaccacagc gugaacccga acugcuacgc caaggugaug     2100

auggucaacg gggaccaccg caucggcauc uucgccaagc gggccaucca gaccggggag     2160

gagcuguucu ucgacuaccg cuacucccag gccgacgcgc ucaaguacgu gggcaucgag     2220

cgggagaugg agauccccug a                                               2241


<210>  1514
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EZH2__Homo_sapiens__AAC51520

<400>  1514
augggccaga ccggcaagaa guccgagaag ggccccgucu gcuggcgcaa gcgcgucaag       60

uccgaguaca ugcgccuccg ccagcucaag cgcuuccgcc gcgccgacga ggucaagucc      120

auguucuccu ccaaccgcca gaagauccuc gagcgcaccg agauccucaa ccaggagugg      180

aagcagcgcc gcauccagcc cguccacauc cucaccuccg ucuccucccu ccgcggcacc      240

cgcgagugcu ccgucaccuc cgaccucgac uuccccaccc aggucauccc ccucaagacc      300

cucaacgccg ucgccuccgu ccccaucaug uacuccuggu ccccccucca gcagaacuuc      360

auggucgagg acgagaccgu ccuccacaac auccccuaca ugggcgacga gguccucgac      420

caggacggca ccuucaucga ggagcucauc aagaacuacg acggcaaggu ccacggcgac      480

cgcgagugcg gcuucaucaa cgacgagauc uucgucgagc ucgucaacgc ccucggccag      540

uacaacgacg acgacgacga cgacgacggc gacgaccccg aggagcgcga ggagaagcag      600

aaggaccucg aggaccaccg cgacgacaag gagucccgcc ccccccgcaa guuccccucc      660

gacaagaucu ucgaggccau cuccuccaug uuccccgaca agggcaccgc cgaggagcuc      720

aaggagaagu acaaggagcu caccgagcag cagcuccccg gcgcccuccc ccccgagugc      780

acccccaaca ucgacggccc caacgccaag uccguccagc gcgagcaguc ccuccacucc      840

uuccacaccc ucuucugccg ccgcugcuuc aaguacgacu gcuuccucca ccccuuccac      900

gccaccccca acaccuacaa gcgcaagaac accgagaccg cccucgacaa caagcccugc      960

ggcccccagu gcuaccagca ccucgagggc gccaaggagu ucgccgccgc ccucaccgcc     1020

gagcgcauca agaccccccc caagcgcccc ggcggccgcc gccgcggccg ccuccccaac     1080

aacuccuccc gccccuccac ccccaccauc aacguccucg aguccaagga caccgacucc     1140

gaccgcgagg ccggcaccga gaccggcggc gagaacaacg acaaggagga ggaggagaag     1200

aaggacgaga ccuccuccuc cuccgaggcc aacucccgcu gccagacccc caucaagaug     1260

aagcccaaca ucgagccccc cgagaacguc gagugguccg gcgccgaggc cuccauguuc     1320

cgcguccuca ucggcaccua cuacgacaac uucugcgcca ucgcccgccu caucggcacc     1380

aagaccugcc gccaggucua cgaguuccgc gucaaggagu ccuccaucau cgcccccgcc     1440

cccgccgagg acgucgacac ccccccccgc aagaagaagc gcaagcaccg ccucugggcc     1500

gcccacugcc gcaagaucca gcucaagaag gacggcuccu ccaaccacgu cuacaacuac     1560

cagcccugcg accacccccg ccagcccugc gacuccuccu gccccugcgu caucgcccag     1620

aacuucugcg agaaguucug ccagugcucc uccgagugcc agaaccgcuu ccccggcugc     1680

cgcugcaagg cccagugcaa caccaagcag ugccccugcu accucgccgu ccgcgagugc     1740

gaccccgacc ucugccucac cugcggcgcc gccgaccacu gggacuccaa gaacgucucc     1800

ugcaagaacu gcuccaucca gcgcggcucc aagaagcacc uccuccucgc ccccuccgac     1860

gucgccggcu ggggcaucuu caucaaggac cccguccaga agaacgaguu caucuccgag     1920

uacugcggcg agaucaucuc ccaggacgag gccgaccgcc gcggcaaggu cuacgacaag     1980

uacaugugcu ccuuccucuu caaccucaac aacgacuucg ucgucgacgc cacccgcaag     2040

ggcaacaaga uccgcuucgc caaccacucc gucaacccca acugcuacgc caaggucaug     2100

auggucaacg gcgaccaccg caucggcauc uucgccaagc gcgccaucca gaccggcgag     2160

gagcucuucu ucgacuaccg cuacucccag gccgacgccc ucaaguacgu cggcaucgag     2220

cgcgagaugg agauccccug a                                               2241


<210>  1515
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EZH2__Homo_sapiens__AAC51520

<400>  1515
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa aagggucaag       60

uccgaauaca ugcggcugcg ccaacucaaa cgauuccgua gagccgacga gguuaagucu      120

auguuuucaa guaacaggca gaagauccuu gaacggacag agauucugaa ucaggaaugg      180

aaacagcgca gaauacaacc ugugcacauc uugacuagcg uauccucuuu aagggguacg      240

cgggaguguu cggugaccuc agaucuggac uucccaacac aggucauucc gcuaaagacu      300

cucaacgcug uggcaagcgu ucccaucaug uauaguuggu ccccucugca gcagaauuuu      360

augguggagg augaaaccgu ccuucauaac auuccauaca ugggcgacga ggugcuggau      420

caagacggga cauucaucga agaguugauc aaaaauuaug auggaaaggu acacggcgac      480

cgcgagugcg guuuuauaaa cgaugaaauu uucguugagc ucgugaaugc ccuggggcag      540

uacaacgacg augacgauga cgacgaugga gacgaucccg aagaacgaga agagaaacag      600

aaggaccugg aggaucauag agacgauaag gaaucuaggc cuccacggaa auuucccagc      660

gacaagaucu ucgaggcgau uuccucaaug uuuccugaua aaggcaccgc ugaagaacuc      720

aaggaaaaau auaaggaguu aacugagcag caacugccag gcgcccuucc gcccgaaugu      780

acaccuaaua ucgacgggcc aaacgcaaaa aguguccagc gugagcagag cuugcacucu      840

uuccauaccc uguuuugccg cagauguuuc aaguacgauu gcuuucuaca ccccuuccac      900

gccacgccua auacuuauaa gaggaaaaac accgaaacag cucucgacaa uaagccaugu      960

ggaccccaau gcuaccagca ucuggagggu gcaaaagagu ucgccgcugc ccuuacugcg     1020

gagcggauaa agaccccgcc uaaacgaccc ggcgggcgca gaaggggacg gcugccaaac     1080

aauuccucac gcccuagcac acccaccauu aacguguugg agaguaagga cacggauucu     1140

gacagagaag caggcacuga gacagguggg gaaaacaaug auaaggagga ggaagagaaa     1200

aaggacgaaa ccuccagcuc gucugaggcc aacuccaggu gucagacucc aaucaaaaug     1260

aagcccaaua uugaaccucc agagaacgug gaguggucag gagcugaagc caguauguuu     1320

cguguccuca ucggcacaua cuaugauaau uucugcgcaa ucgcucggcu gauuggcacc     1380

aaaacguguc gacagguuua cgaguuuaga gugaaggaaa gcuccauaau cgccccggcg     1440

cccgccgagg acguagauac cccuccaagg aagaaaaagc gcaaacaccg guuaugggca     1500

gcucauugca gaaagauuca acugaaaaag gacgggucua gcaaccacgu guauaauuac     1560

cagcccugcg aucacccuag gcagccaugu gacucaaguu gccccugugu caucgcccag     1620

aacuucugcg aaaaguuuug ucaaugcucc agcgaguguc agaaucgcuu cccgggaugc     1680

cgauguaaag cucagugcaa cacaaagcag uguccuugcu aucucgccgu gcgggagugc     1740

gauccagacc uuugucugac uugcggugca gccgaucauu gggacucuaa aaauguuuca     1800

uguaagaacu gcaguauaca acguggcagc aaaaagcacu ugcuacuggc ucccuccgac     1860

guggcggggu ggggaauuuu uaucaaagau ccuguccaga agaaugaguu caucucugag     1920

uacuguggcg aaauuaucuc gcaggacgag gcagauagaa gggguaaggu guaugacaaa     1980

uacaugugca gcuuucucuu caaccugaau aacgauuuug uaguugacgc cacccgcaag     2040

gggaacaaaa uucgguucgc uaaucauucc gugaacccca auuguuacgc caaggucaug     2100

auggugaacg gcgaucacag aauaggaauc uuugcaaaaa gggccauuca gacaggcgag     2160

gaacuuuucu ucgacuaucg auacucacaa gcugaugccc ugaaguaugu cgggaucgag     2220

cgcgaaaugg agaucccaug a                                               2241


<210>  1516
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EZH2__Homo_sapiens__AAC51520

<400>  1516
augggccaga ccggcaagaa gagcgagaag ggccccgugu gcuggagaaa gagagugaag       60

agcgaguaca ugagacugag acagcugaag agauucagaa gagccgacga ggugaagagc      120

auguucagca gcaacagaca gaagauccug gagagaaccg agauccugaa ccaggagugg      180

aagcagagaa gaauccagcc cgugcacauc cugaccagcg ugagcagccu gagaggcacc      240

agagagugca gcgugaccag cgaccuggac uuccccaccc aggugauccc ccugaagacc      300

cugaacgccg uggccagcgu gcccaucaug uacagcugga gcccccugca gcagaacuuc      360

augguggagg acgagaccgu gcugcacaac auccccuaca ugggcgacga ggugcuggac      420

caggacggca ccuucaucga ggagcugauc aagaacuacg acggcaaggu gcacggcgac      480

agagagugcg gcuucaucaa cgacgagauc uucguggagc uggugaacgc ccugggccag      540

uacaacgacg acgacgacga cgacgacggc gacgaccccg aggagagaga ggagaagcag      600

aaggaccugg aggaccacag agacgacaag gagagcagac cccccagaaa guuccccagc      660

gacaagaucu ucgaggccau cagcagcaug uuccccgaca agggcaccgc cgaggagcug      720

aaggagaagu acaaggagcu gaccgagcag cagcugcccg gcgcccugcc ccccgagugc      780

acccccaaca ucgacggccc caacgccaag agcgugcaga gagagcagag ccugcacagc      840

uuccacaccc uguucugcag aagaugcuuc aaguacgacu gcuuccugca ccccuuccac      900

gccaccccca acaccuacaa gagaaagaac accgagaccg cccuggacaa caagcccugc      960

ggcccccagu gcuaccagca ccuggagggc gccaaggagu ucgccgccgc ccugaccgcc     1020

gagagaauca agaccccccc caagagaccc ggcggcagaa gaagaggcag acugcccaac     1080

aacagcagca gacccagcac ccccaccauc aacgugcugg agagcaagga caccgacagc     1140

gacagagagg ccggcaccga gaccggcggc gagaacaacg acaaggagga ggaggagaag     1200

aaggacgaga ccagcagcag cagcgaggcc aacagcagau gccagacccc caucaagaug     1260

aagcccaaca ucgagccccc cgagaacgug gaguggagcg gcgccgaggc cagcauguuc     1320

agagugcuga ucggcaccua cuacgacaac uucugcgcca ucgccagacu gaucggcacc     1380

aagaccugca gacaggugua cgaguucaga gugaaggaga gcagcaucau cgcccccgcc     1440

cccgccgagg acguggacac cccccccaga aagaagaaga gaaagcacag acugugggcc     1500

gcccacugca gaaagaucca gcugaagaag gacggcagca gcaaccacgu guacaacuac     1560

cagcccugcg accaccccag acagcccugc gacagcagcu gccccugcgu gaucgcccag     1620

aacuucugcg agaaguucug ccagugcagc agcgagugcc agaacagauu ccccggcugc     1680

agaugcaagg cccagugcaa caccaagcag ugccccugcu accuggccgu gagagagugc     1740

gaccccgacc ugugccugac cugcggcgcc gccgaccacu gggacagcaa gaacgugagc     1800

ugcaagaacu gcagcaucca gagaggcagc aagaagcacc ugcugcuggc ccccagcgac     1860

guggccggcu ggggcaucuu caucaaggac cccgugcaga agaacgaguu caucagcgag     1920

uacugcggcg agaucaucag ccaggacgag gccgacagaa gaggcaaggu guacgacaag     1980

uacaugugca gcuuccuguu caaccugaac aacgacuucg ugguggacgc caccagaaag     2040

ggcaacaaga ucagauucgc caaccacagc gugaacccca acugcuacgc caaggugaug     2100

auggugaacg gcgaccacag aaucggcauc uucgccaaga gagccaucca gaccggcgag     2160

gagcuguucu ucgacuacag auacagccag gccgacgccc ugaaguacgu gggcaucgag     2220

agagagaugg agauccccug a                                               2241


<210>  1517
<211>  2241
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EZH2__Homo_sapiens__AAC51520

<400>  1517
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa acgggucaag       60

uccgaauaca ugcgccugag acaacucaaa cgguuccgca gagccgacga gguuaagucu      120

auguuuagcu ccaaccggca gaagauccug gaacgcacag agauucuuaa ucaggaaugg      180

aaacagagac ggauccaacc ugugcacauu cugacgucug ugagcucccu ccgcggcacc      240

agagaguguu cugucacaag cgaucuggac uucccgaccc aggugauccc ccuuaagaca      300

cugaacgcug uugccuccgu gccuauuaug uauagcuggu cuccccucca gcagaauuuu      360

auggucgagg augaaaccgu gcugcauaac aucccuuaca ugggggacga gguucuggau      420

caagacggaa cauucaucga agaacucauu aaaaauuaug auggcaaggu gcacggggac      480

cgggagugcg gauuuaucaa cgaugaaauu uucgucgagc uggugaaugc gcuuggccag      540

uacaacgacg augacgauga cgacgauggc gacgaucccg aagaacgcga agagaaacag      600

aaggaccugg aggaucauag agacgauaag gaaucccggc cuccgcgcaa auuucccagc      660

gacaagaucu ucgaggcuau uucuuccaug uuuccugaua aagggaccgc cgaagaacuc      720

aaggaaaaau auaaggagcu gacggagcag caacuucccg gagcccugcc ucccgaaugu      780

accccgaaua ucgacggccc uaacgcuaaa agcgugcaga gagagcaguc ucuccacucc      840

uuccauacac uguuuugccg gagauguuuc aaguacgauu gcuuucugca ccccuuccac      900

gccaccccua auacauauaa gcgcaaaaac accgaaacgg cucucgacaa uaagcccugu      960

gggccccaau gcuaccagca ucuggaggga gccaaagagu ucgcggccgc ucuuacagcc     1020

gagcggauua agaccccucc gaaaagaccc ggcgggcgcc ggagaggacg ccugccuaac     1080

aauagcuccc ggcccucuac accuaccauc aacguccucg agagcaagga caccgauucc     1140

gacagagaag cuggcacaga gacgggcggg gaaaacaaug auaaggagga ggaagagaaa     1200

aaggacgaaa ccucuagcuc cagcgaggcc aacucucgcu gucagacacc caucaaaaug     1260

aagccgaaua uugaaccucc cgagaacguu gaguggagcg gagcggaagc cuccauguuu     1320

cgggugcuga ucggcaccua cuaugauaau uucugcgcua uugccagacu uaucgggaca     1380

aaaaccuguc gccaggugua cgaguuucgg gucaaggaau cuagcauuau cgcuccugcc     1440

cccgccgagg acguggauac gccucccaga aagaaaaagc ggaaacaccg ccugugggcu     1500

gcgcauugca gaaagaucca acucaaaaag gacggaucca gcaaccacgu uuauaauuac     1560

cagccgugcg aucacccucg gcagcccugu gacucuuccu gccccugugu gauugcccag     1620

aacuucugcg aaaaguuuug ucaaugcagc ucugaguguc agaauagauu cccuggcugc     1680

cgcuguaaag cucagugcaa cacaaagcag uguccgugcu aucuggccgu ccgggagugc     1740

gaucccgacc ugugucugac cugcggggcc gcugaucauu gggacuccaa aaaugugagc     1800

uguaagaacu gcuccaucca aagaggaucu aaaaagcauc uccuucuggc cccuagcgac     1860

guugcgggcu ggggcauuuu uaucaaagau cccgugcaga agaaugaguu cauuuccgag     1920

uacugugggg aaaucaucuc ucaggacgag gcugaucgca gaggaaaggu cuaugacaaa     1980

uacaugugca gcuuucucuu caaccugaau aacgauuuug uggucgacgc cacccggaag     2040

ggcaacaaaa uucgcuucgc caaucacucc gugaacccua auuguuacgc uaagguuaug     2100

auggugaacg gggaucacag aaucggaauu uuugccaaac gggcuaucca gacaggcgag     2160

gagcuuuucu ucgacuaucg cuacagccaa gccgaugcgc ugaaguaugu cgggauugag     2220

agagaaaugg agauccccug a                                               2241


<210>  1518
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__S4S3R8

<400>  1518

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly 
                85                  90                  95      


Asp Glu Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys 
            100                 105                 110         


Asn Tyr Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn 
        115                 120                 125             


Asp Glu Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp 
    130                 135                 140                 


Asp Asp Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys 
145                 150                 155                 160 


Gln Lys Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro 
                165                 170                 175     


Arg Lys Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe 
            180                 185                 190         


Pro Asp Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu 
        195                 200                 205             


Thr Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn 
    210                 215                 220                 


Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His 
225                 230                 235                 240 


Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe 
                245                 250                 255     


Leu His Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr 
            260                 265                 270         


Glu Thr Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His 
        275                 280                 285             


Leu Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile 
    290                 295                 300                 


Lys Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro 
305                 310                 315                 320 


Asn Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser 
                325                 330                 335     


Lys Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu 
            340                 345                 350         


Asn Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser 
        355                 360                 365             


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn 
    370                 375                 380                 


Ile Glu Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met 
385                 390                 395                 400 


Phe Arg Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala 
                405                 410                 415     


Arg Leu Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val 
            420                 425                 430         


Lys Glu Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr 
        435                 440                 445             


Pro Pro Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys 
    450                 455                 460                 


Arg Lys Ile Gln Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn 
465                 470                 475                 480 


Tyr Gln Pro Cys Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro 
                485                 490                 495     


Cys Val Ile Ala Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser 
            500                 505                 510         


Glu Cys Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn 
        515                 520                 525             


Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp 
    530                 535                 540                 


Leu Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val 
545                 550                 555                 560 


Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu 
                565                 570                 575     


Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro 
            580                 585                 590         


Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser 
        595                 600                 605             


Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys 
    610                 615                 620                 


Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg 
625                 630                 635                 640 


Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys 
                645                 650                 655     


Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe 
            660                 665                 670         


Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg 
        675                 680                 685             


Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met 
    690                 695                 700                 


Glu Ile Pro 
705         


<210>  1519
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EZH2__Homo_sapiens__AEN79481

<400>  1519
augggccaga cugggaagaa aucugagaag ggaccaguuu guuggcggaa gcguguaaaa       60

ucagaguaca ugcgacugag acagcucaag agguucagac gagcugauga aguaaagagu      120

auguuuaguu ccaaucguca gaaaauuuug gaaagaacgg aaaucuuaaa ccaagaaugg      180

aaacagcgaa ggauacagcc ugugcacauc cugacuucug ugagcucauu gcgcgggacu      240

agggaggugg aagaugaaac uguuuuacau aacauuccuu auaugggaga ugaaguuuua      300

gaucaggaug guacuuucau ugaagaacua auaaaaaauu augaugggaa aguacacggg      360

gauagagaau guggguuuau aaaugaugaa auuuuugugg aguuggugaa ugcccuuggu      420

caauauaaug augaugacga ugaugaugau ggagacgauc cugaagaaag agaagaaaag      480

cagaaagauc uggaggauca ccgagaugau aaagaaagcc gcccaccucg gaaauuuccu      540

ucugauaaaa uuuuugaagc cauuuccuca auguuuccag auaagggcac agcagaagaa      600

cuaaaggaaa aauauaaaga acucaccgaa cagcagcucc caggcgcacu uccuccugaa      660

uguaccccca acauagaugg accaaaugcu aaaucuguuc agagagagca aagcuuacac      720

uccuuucaua cgcuuuucug uaggcgaugu uuuaaauaug acugcuuccu acauccuuuu      780

caugcaacac ccaacacuua uaagcggaag aacacagaaa cagcucuaga caacaaaccu      840

uguggaccac aguguuacca gcauuuggag ggagcaaagg aguuugcugc ugcucucacc      900

gcugagcgga uaaagacccc accaaaacgu ccaggaggcc gcagaagagg acggcuuccc      960

aauaacagua gcaggcccag cacccccacc auuaaugugc uggaaucaaa ggauacagac     1020

agugauaggg aagcagggac ugaaacgggg ggagagaaca augauaaaga agaagaagag     1080

aagaaagaug aaacuucgag cuccucugaa gcaaauucuc ggugucaaac accaauaaag     1140

augaagccaa auauugaacc uccugagaau guggagugga guggugcuga agccucaaug     1200

uuuagagucc ucauuggcac uuacuaugac aauuucugug ccauugcuag guuaauuggg     1260

accaaaacau guagacaggu guaugaguuu agagucaaag aaucuagcau cauagcucca     1320

gcucccgcug aggaugugga uacuccucca aggaaaaaga agaggaaaca ccgguugugg     1380

gcugcacacu gcagaaagau acagcugaaa aaggacggcu ccucuaacca uguuuacaac     1440

uaucaacccu gugaucaucc acggcagccu ugugacaguu cgugcccuug ugugauagca     1500

caaaauuuuu gugaaaaguu uugucaaugu aguucagagu gucaaaaccg cuuuccggga     1560

ugccgcugca aagcacagug caacaccaag cagugcccgu gcuaccuggc uguccgagag     1620

ugugacccug accucugucu uacuugugga gccgcugacc auugggacag uaaaaaugug     1680

uccugcaaga acugcaguau ucagcggggc uccaaaaagc aucuauugcu ggcaccaucu     1740

gacguggcag gcugggggau uuuuaucaaa gauccugugc agaaaaauga auucaucuca     1800

gaauacugug gagagauuau uucucaagau gaagcugaca gaagagggaa aguguaugau     1860

aaauacaugu gcagcuuucu guucaacuug aacaaugauu uuguggugga ugcaacccgc     1920

aaggguaaca aaauucguuu ugcaaaucau ucgguaaauc caaacugcua ugcaaaaguu     1980

augaugguua acggugauca caggauaggu auuuuugcca agagagccau ccagacuggc     2040

gaagagcugu uuuuugauua cagauacagc caggcugaug cccugaagua ugucggcauc     2100

gaaagagaaa uggaaauccc uuga                                            2124


<210>  1520
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EZH2__Homo_sapiens__AEN79481

<400>  1520
augggccaga ccgggaagaa guccgagaag ggccccgugu gcuggcgcaa gcgggucaag       60

agcgaguaca ugcgccugcg gcagcucaag cgcuuccggc gcgccgacga ggucaagagc      120

auguucucca gcaaccggca gaagauccug gagcgcaccg agauccugaa ccaggagugg      180

aagcagcggc gcauccagcc ggugcacauc cucacguccg ugagcucccu gcgggggacc      240

cgcgaggugg aggacgagac cgugcugcac aacauccccu acaugggcga cgagguccuc      300

gaccaggacg ggaccuucau cgaggagcug aucaagaacu acgacggcaa ggugcacggc      360

gaccgggagu gcggguucau caacgacgag aucuucgugg agcuggucaa cgcccucggc      420

caguacaacg acgacgacga cgacgacgac ggggacgacc ccgaggagcg cgaggagaag      480

cagaaggacc uggaggacca ccgggacgac aaggagagcc ggcccccgcg caaguucccc      540

uccgacaaga ucuucgaggc gaucagcucc auguuccccg acaagggcac ggccgaggag      600

cugaaggaga aguacaagga gcucaccgag cagcagcugc ccggggcccu gccgcccgag      660

ugcaccccca acaucgacgg ccccaacgcc aagagcgugc agcgcgagca gucccuccac      720

agcuuccaca cccuguucug ccggcgcugc uucaaguacg acugcuuccu gcacccguuc      780

cacgccacgc ccaacaccua caagcggaag aacaccgaga ccgcgcucga caacaagccc      840

ugcggccccc agugcuacca gcaccuggag ggggccaagg aguucgccgc cgcgcugacg      900

gccgagcgca ucaagacccc gcccaagcgc cccggcgggc ggcgccgggg ccgccucccc      960

aacaacucca gccggccguc cacccccacc aucaacgugc uggagagcaa ggacacggac     1020

uccgaccgcg aggccggcac cgagaccggg ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccagcag cuccagcgag gccaacuccc ggugccagac gcccaucaag     1140

augaagccca acaucgagcc gcccgagaac gucgagugga gcggggccga ggcguccaug     1200

uuccgcgugc ugaucggcac cuacuacgac aacuucugcg ccaucgcccg gcucaucggg     1260

accaagaccu gccgccaggu guacgaguuc cgggucaagg agagcuccau caucgccccc     1320

gcccccgcgg aggacgugga cacgccgccc cgcaagaaga agcggaagca ccgccugugg     1380

gccgcccacu gccggaagau ccagcugaag aaggacggca gcuccaacca cguguacaac     1440

uaccagcccu gcgaccaccc gcgccagccc ugcgacagcu ccugccccug cgucaucgcc     1500

cagaacuucu gcgagaaguu cugccagugc agcuccgagu gccagaaccg guuccccggc     1560

ugccgcugca aggcccagug caacaccaag cagugcccgu gcuaccucgc ggugcgggag     1620

ugcgaccccg accugugccu gaccugcggg gccgccgacc acugggacag caagaacgug     1680

uccugcaaga acugcagcau ccagcgcggc uccaagaagc accuccugcu ggcccccagc     1740

gacgucgccg gguggggcau cuucaucaag gaccccgugc agaagaacga guucaucucc     1800

gaguacugcg gggagaucau cagccaggac gaggcggacc gccggggcaa gguguacgac     1860

aaguacaugu gcagcuuccu cuucaaccug aacaacgacu ucgucgugga cgccacccgc     1920

aagggcaaca agauccgguu cgccaaccac uccgucaacc cgaacugcua cgccaaggug     1980

augaugguga acggggacca ccgcaucggc aucuucgcga agcgggccau ccagacgggg     2040

gaggagcugu ucuucgacua ccgcuacagc caggccgacg cccucaagua cgucggcauc     2100

gagcgggaga uggagauccc cuga                                            2124


<210>  1521
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EZH2__Homo_sapiens__AEN79481

<400>  1521
augggccaga ccggcaagaa guccgagaag ggccccgucu gcuggcgcaa gcgcgucaag       60

uccgaguaca ugcgccuccg ccagcucaag cgcuuccgcc gcgccgacga ggucaagucc      120

auguucuccu ccaaccgcca gaagauccuc gagcgcaccg agauccucaa ccaggagugg      180

aagcagcgcc gcauccagcc cguccacauc cucaccuccg ucuccucccu ccgcggcacc      240

cgcgaggucg aggacgagac cguccuccac aacauccccu acaugggcga cgagguccuc      300

gaccaggacg gcaccuucau cgaggagcuc aucaagaacu acgacggcaa gguccacggc      360

gaccgcgagu gcggcuucau caacgacgag aucuucgucg agcucgucaa cgcccucggc      420

caguacaacg acgacgacga cgacgacgac ggcgacgacc ccgaggagcg cgaggagaag      480

cagaaggacc ucgaggacca ccgcgacgac aaggaguccc gccccccccg caaguucccc      540

uccgacaaga ucuucgaggc caucuccucc auguuccccg acaagggcac cgccgaggag      600

cucaaggaga aguacaagga gcucaccgag cagcagcucc ccggcgcccu cccccccgag      660

ugcaccccca acaucgacgg ccccaacgcc aaguccgucc agcgcgagca gucccuccac      720

uccuuccaca cccucuucug ccgccgcugc uucaaguacg acugcuuccu ccaccccuuc      780

cacgccaccc ccaacaccua caagcgcaag aacaccgaga ccgcccucga caacaagccc      840

ugcggccccc agugcuacca gcaccucgag ggcgccaagg aguucgccgc cgcccucacc      900

gccgagcgca ucaagacccc ccccaagcgc cccggcggcc gccgccgcgg ccgccucccc      960

aacaacuccu cccgccccuc cacccccacc aucaacgucc ucgaguccaa ggacaccgac     1020

uccgaccgcg aggccggcac cgagaccggc ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccuccuc cuccuccgag gccaacuccc gcugccagac ccccaucaag     1140

augaagccca acaucgagcc ccccgagaac gucgaguggu ccggcgccga ggccuccaug     1200

uuccgcgucc ucaucggcac cuacuacgac aacuucugcg ccaucgcccg ccucaucggc     1260

accaagaccu gccgccaggu cuacgaguuc cgcgucaagg aguccuccau caucgccccc     1320

gcccccgccg aggacgucga cacccccccc cgcaagaaga agcgcaagca ccgccucugg     1380

gccgcccacu gccgcaagau ccagcucaag aaggacggcu ccuccaacca cgucuacaac     1440

uaccagcccu gcgaccaccc ccgccagccc ugcgacuccu ccugccccug cgucaucgcc     1500

cagaacuucu gcgagaaguu cugccagugc uccuccgagu gccagaaccg cuuccccggc     1560

ugccgcugca aggcccagug caacaccaag cagugccccu gcuaccucgc cguccgcgag     1620

ugcgaccccg accucugccu caccugcggc gccgccgacc acugggacuc caagaacguc     1680

uccugcaaga acugcuccau ccagcgcggc uccaagaagc accuccuccu cgcccccucc     1740

gacgucgccg gcuggggcau cuucaucaag gaccccgucc agaagaacga guucaucucc     1800

gaguacugcg gcgagaucau cucccaggac gaggccgacc gccgcggcaa ggucuacgac     1860

aaguacaugu gcuccuuccu cuucaaccuc aacaacgacu ucgucgucga cgccacccgc     1920

aagggcaaca agauccgcuu cgccaaccac uccgucaacc ccaacugcua cgccaagguc     1980

augaugguca acggcgacca ccgcaucggc aucuucgcca agcgcgccau ccagaccggc     2040

gaggagcucu ucuucgacua ccgcuacucc caggccgacg cccucaagua cgucggcauc     2100

gagcgcgaga uggagauccc cuga                                            2124


<210>  1522
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EZH2__Homo_sapiens__AEN79481

<400>  1522
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa aagggucaag       60

uccgaauaca ugcggcugcg ccaacucaaa cgauuccgua gagccgacga gguuaagucu      120

auguuuucaa guaacaggca gaagauccuu gaacggacag agauucugaa ucaggaaugg      180

aaacagcgca gaauacaacc ugugcacauc uugacuagcg uauccucuuu aagggguacg      240

cgggaggugg aggaugaaac cguccugcau aacauuccau auaugggcga cgaggugcua      300

gaucaggacg ggacauucau cgaagaacuc auuaagaauu acgauggaaa aguucacggc      360

gaccgcgagu gugguuuuau caacgaugaa auauucgugg agcuggucaa ugcucuuggg      420

caguauaacg acgaugacga ugacgaugac ggagacgauc cggaagaacg agaagagaag      480

cagaaagacc uggaggauca uagagacgau aaggaaucga ggcccccucg gaaguuucca      540

ucagacaaaa ucuucgaggc aauuagcagu auguuucccg auaagggcac ugccgaagag      600

uugaaagaaa aguacaaaga gcucaccgag caacagcugc cuggcgcgcu gccacccgaa      660

ugcacaccua auaucgacgg gccaaacgcu aaguccgugc agcgugagca gucucuccac      720

agcuuccaua ccuuauuuug ucgcagaugc uucaaauaug auuguuuucu gcacccguuc      780

cacgccacuc ccaauacaua caagaggaag aacaccgaaa cggcacuuga caauaaaccu      840

ugcggaccac aauguuauca gcauuuggag ggugccaagg aauuugcugc agcccugacu      900

gcugagcgga uuaaaacacc cccuaagcga ccaggcgggc gcagaagggg acggcuaccc      960

aacaauuccu cacgcccgag uaccccuacu aucaacguac ucgagagcaa agauaccgac     1020

ucugacagag aagccggcac agagaccggu ggggaaaaua acgauaagga ggaggaagag     1080

aagaaagacg aaacguccuc aagcagugag gcgaacucua ggugccagac ucccauaaag     1140

augaaaccaa auauugaacc ucccgagaac guugaguggu ccggagcaga agccagcaug     1200

uuccgugugc ugaucggcac auacuacgau aauuucugug cuauugcccg gcuuaucggc     1260

accaagacuu gccgacaagu cuaugaguuu agagugaaag aaucgucuau cauugcacca     1320

gcucccgccg aggacgugga uacaccucca aggaagaaga aacgcaagca ccggcugugg     1380

gcggcccauu guagaaaaau acaguugaag aaagacgggu ccucaaacca cgucuacaau     1440

uaucagccgu gcgaucaccc caggcagccu ugcgacagua gcuguccaug cguuaucgca     1500

caaaacuucu gugaaaaguu uugccagugu uccucugagu gccagaaucg cuuccccgga     1560

ugucgaugca aggcucagug uaacaccaaa caaugcccuu guuaccucgc cgugcgggag     1620

ugcgauccag accugugcuu aacguguggu gcugccgauc auugggacag caagaaugua     1680

ucaugcaaaa acuguaguau ucagcguggc uccaagaaac aucugcuccu ugcacccagc     1740

gauguggccg gguggggaau cuuuauaaag gacccggucc agaaaaauga guucauuucu     1800

gaguauugcg gcgaaaucau cucacaggac gaggcugaua gaagggguaa gguguacgac     1860

aaguauaugu guaguuuucu guucaacuug aauaacgauu uuguugugga cgcgacccgc     1920

aaagggaaua agauucgguu cgcaaaccac agcgucaacc cuaauugcua cgccaaagug     1980

augaugguaa acggcgauca cagaaucgga auuuuugcua agagggccau acaaacaggc     2040

gaggagcuau ucuuugacua ccgauauucc caggcagaug cccugaaaua cguugggauc     2100

gagcgcgaaa uggagauucc auga                                            2124


<210>  1523
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EZH2__Homo_sapiens__AEN79481

<400>  1523
augggccaga ccggcaagaa gagcgagaag ggccccgugu gcuggagaaa gagagugaag       60

agcgaguaca ugagacugag acagcugaag agauucagaa gagccgacga ggugaagagc      120

auguucagca gcaacagaca gaagauccug gagagaaccg agauccugaa ccaggagugg      180

aagcagagaa gaauccagcc cgugcacauc cugaccagcg ugagcagccu gagaggcacc      240

agagaggugg aggacgagac cgugcugcac aacauccccu acaugggcga cgaggugcug      300

gaccaggacg gcaccuucau cgaggagcug aucaagaacu acgacggcaa ggugcacggc      360

gacagagagu gcggcuucau caacgacgag aucuucgugg agcuggugaa cgcccugggc      420

caguacaacg acgacgacga cgacgacgac ggcgacgacc ccgaggagag agaggagaag      480

cagaaggacc uggaggacca cagagacgac aaggagagca gaccccccag aaaguucccc      540

agcgacaaga ucuucgaggc caucagcagc auguuccccg acaagggcac cgccgaggag      600

cugaaggaga aguacaagga gcugaccgag cagcagcugc ccggcgcccu gccccccgag      660

ugcaccccca acaucgacgg ccccaacgcc aagagcgugc agagagagca gagccugcac      720

agcuuccaca cccuguucug cagaagaugc uucaaguacg acugcuuccu gcaccccuuc      780

cacgccaccc ccaacaccua caagagaaag aacaccgaga ccgcccugga caacaagccc      840

ugcggccccc agugcuacca gcaccuggag ggcgccaagg aguucgccgc cgcccugacc      900

gccgagagaa ucaagacccc ccccaagaga cccggcggca gaagaagagg cagacugccc      960

aacaacagca gcagacccag cacccccacc aucaacgugc uggagagcaa ggacaccgac     1020

agcgacagag aggccggcac cgagaccggc ggcgagaaca acgacaagga ggaggaggag     1080

aagaaggacg agaccagcag cagcagcgag gccaacagca gaugccagac ccccaucaag     1140

augaagccca acaucgagcc ccccgagaac guggagugga gcggcgccga ggccagcaug     1200

uucagagugc ugaucggcac cuacuacgac aacuucugcg ccaucgccag acugaucggc     1260

accaagaccu gcagacaggu guacgaguuc agagugaagg agagcagcau caucgccccc     1320

gcccccgccg aggacgugga cacccccccc agaaagaaga agagaaagca cagacugugg     1380

gccgcccacu gcagaaagau ccagcugaag aaggacggca gcagcaacca cguguacaac     1440

uaccagcccu gcgaccaccc cagacagccc ugcgacagca gcugccccug cgugaucgcc     1500

cagaacuucu gcgagaaguu cugccagugc agcagcgagu gccagaacag auuccccggc     1560

ugcagaugca aggcccagug caacaccaag cagugccccu gcuaccuggc cgugagagag     1620

ugcgaccccg accugugccu gaccugcggc gccgccgacc acugggacag caagaacgug     1680

agcugcaaga acugcagcau ccagagaggc agcaagaagc accugcugcu ggcccccagc     1740

gacguggccg gcuggggcau cuucaucaag gaccccgugc agaagaacga guucaucagc     1800

gaguacugcg gcgagaucau cagccaggac gaggccgaca gaagaggcaa gguguacgac     1860

aaguacaugu gcagcuuccu guucaaccug aacaacgacu ucguggugga cgccaccaga     1920

aagggcaaca agaucagauu cgccaaccac agcgugaacc ccaacugcua cgccaaggug     1980

augaugguga acggcgacca cagaaucggc aucuucgcca agagagccau ccagaccggc     2040

gaggagcugu ucuucgacua cagauacagc caggccgacg cccugaagua cgugggcauc     2100

gagagagaga uggagauccc cuga                                            2124


<210>  1524
<211>  2124
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EZH2__Homo_sapiens__AEN79481

<400>  1524
augggccaga ccgggaagaa aagcgagaag ggacccgugu gcuggagaaa acgggucaag       60

uccgaauaca ugcgccugag acaacucaaa cgguuccgca gagccgacga gguuaagucu      120

auguuuagcu ccaaccggca gaagauccug gaacgcacag agauucuuaa ucaggaaugg      180

aaacagagac ggauccaacc ugugcacauu cugacgucug ugagcucccu ccgcggcacc      240

agagaggucg aggaugaaac agugcugcau aacaucccgu auauggggga cgagguucuu      300

gaucaggacg gaaccuucau ugaagaacug aucaagaauu acgauggcaa agugcacggg      360

gaccgggagu guggauuuau caacgaugaa auuuucgucg agcucgugaa ugcucugggc      420

caguauaacg acgaugacga ugacgaugac ggcgacgauc ccgaagaacg cgaagagaag      480

cagaaagacc uggaggauca uagagacgau aaggaaucuc ggccuccccg caaguuuccu      540

agcgacaaaa ucuucgaggc cauuuccagc auguuucccg auaaggggac agcggaggag      600

cucaaagaaa aguacaaaga gcugaccgag caacagcuuc cuggagcucu gccgcccgaa      660

ugcacaccua auaucgacgg ccccaacgcc aagucuguuc agagagagca gucccuccac      720

agcuuccaua cccuguuuug ucggagaugc uucaaauaug auuguuuucu ucacccuuuc      780

cacgccacgc ccaauaccua caagcgcaag aacacagaaa ccgcucugga caauaaaccg      840

ugcgggccuc aauguuauca gcaucucgag ggagccaagg aauuugcugc cgcgcugaca      900

gccgagcgga uuaaaacgcc cccuaagaga cccggcgggc gccggagagg acgccugccc      960

aacaauucuu cccggccuag caccccgaca aucaacgugc ucgagucuaa agauaccgac     1020

uccgacagag aagcuggcac agagaccggc ggggaaaaua acgauaagga ggaggaagag     1080

aagaaagacg aaaccagcuc cucuagcgag gccaacuccc gcugccagac acccauuaag     1140

augaaaccua auaucgaacc cccugagaac gucgagugga gcggagcuga agccucuaug     1200

uuccgggugc ugaucggcac guacuacgau aauuucugug cgauugccag acuuaucggg     1260

accaagacau gccgccaagu guaugaguuu cgggucaaag aauccagcau uaucgcuccc     1320

gccccggcug aggacguuga uaccccuccc agaaagaaga aacggaagca ccgccugugg     1380

gccgcccauu guagaaaaau ucagcucaag aaagacggau cuagcaacca cguguacaau     1440

uaucagccuu gcgaucaccc ccggcagccu ugcgacuccu cuugucccug cgugaucgcu     1500

caaaacuucu gugaaaaguu uugccagugu agcuccgagu gccagaauag auucccgggc     1560

ugucgcugca aggcgcagug uaacacaaaa caaugcccuu guuaccuggc cguccgggag     1620

ugcgaucccg accuuugccu gaccuguggg gcugccgauc auugggacag caagaaugug     1680

ucuugcaaaa acuguuccau ccagagagga agcaagaaac accuccugcu ggcccccucu     1740

gauguugcug gcuggggcau uuuuaucaag gacccugugc agaaaaauga guucauuucc     1800

gaguauugcg gggaaaucau uagccaggac gaggccgauc gcagaggaaa ggucuacgac     1860

aaguauaugu guuccuuucu cuucaaccug aauaacgauu uugugguuga cgcgacgcgg     1920

aaaggcaaua agauccgcuu cgcuaaccau ucugugaacc cgaauugcua cgccaaaguc     1980

augaugguga acggggauca cagaaucgga auuuuugcca agcgggcuau ccaaacaggc     2040

gaggaacuuu ucuuugacua ccgcuauagc caggccgaug cucugaaaua cgucgggauu     2100

gagagagaaa uggagauccc cuga                                            2124


<210>  1525
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FABP7__Homo_sapiens__O15540

<400>  1525

Met Val Glu Ala Phe Cys Ala Thr Trp Lys Leu Thr Asn Ser Gln Asn 
1               5                   10                  15      


Phe Asp Glu Tyr Met Lys Ala Leu Gly Val Gly Phe Ala Thr Arg Gln 
            20                  25                  30          


Val Gly Asn Val Thr Lys Pro Thr Val Ile Ile Ser Gln Glu Gly Asp 
        35                  40                  45              


Lys Val Val Ile Arg Thr Leu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Gln Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Asn 
65                  70                  75                  80  


Cys Lys Ser Val Val Ser Leu Asp Gly Asp Lys Leu Val His Ile Gln 
                85                  90                  95      


Lys Trp Asp Gly Lys Glu Thr Asn Phe Val Arg Glu Ile Lys Asp Gly 
            100                 105                 110         


Lys Met Val Met Thr Leu Thr Phe Gly Asp Val Val Ala Val Arg His 
        115                 120                 125             


Tyr Glu Lys Ala 
    130         


<210>  1526
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FABP7__Homo_sapiens__AAB87141

<400>  1526
augguggagg cuuucugugc uaccuggaag cugaccaaca gucagaacuu ugaugaguac       60

augaaggcuc uaggcguggg cuuugccacu aggcaggugg gaaaugugac caaaccaacg      120

guaauuauca gucaagaagg agacaaagug gucaucagga cucucagcac auucaagaac      180

acggagauua guuuccagcu gggagaagag uuugaugaaa ccacugcaga ugauagaaac      240

uguaagucug uuguuagccu ggauggagac aaacuuguuc acauacagaa augggauggc      300

aaagaaacaa auuuuguaag agaaauuaag gauggcaaaa ugguuaugac ccuuacuuuu      360

ggugaugugg uugcuguucg ccacuaugag aaggcauaa                             399


<210>  1527
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FABP7__Homo_sapiens__AAB87141

<400>  1527
augguggagg ccuucugcgc caccuggaag cugaccaaca gccagaacuu cgacgaguac       60

augaaggcgc ucggcgucgg guucgccacg cgccaggugg gcaacgugac caagcccacc      120

gucaucaucu cccaggaggg ggacaaggug gugauccgga cccugagcac guucaagaac      180

accgagaucu ccuuccagcu gggcgaggag uucgacgaga ccaccgccga cgaccgcaac      240

ugcaagagcg ucgugucccu cgacggggac aagcuggugc acauccagaa gugggacggc      300

aaggagacga acuucguccg ggagaucaag gacggcaaga uggugaugac ccugaccuuc      360

ggggacgugg ucgccgugcg ccacuacgag aaggccuga                             399


<210>  1528
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FABP7__Homo_sapiens__AAB87141

<400>  1528
auggucgagg ccuucugcgc caccuggaag cucaccaacu cccagaacuu cgacgaguac       60

augaaggccc ucggcgucgg cuucgccacc cgccaggucg gcaacgucac caagcccacc      120

gucaucaucu cccaggaggg cgacaagguc gucauccgca cccucuccac cuucaagaac      180

accgagaucu ccuuccagcu cggcgaggag uucgacgaga ccaccgccga cgaccgcaac      240

ugcaaguccg ucgucucccu cgacggcgac aagcucgucc acauccagaa gugggacggc      300

aaggagacca acuucguccg cgagaucaag gacggcaaga uggucaugac ccucaccuuc      360

ggcgacgucg ucgccguccg ccacuacgag aaggccuga                             399


<210>  1529
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FABP7__Homo_sapiens__AAB87141

<400>  1529
augguggagg ccuucugcgc uaccuggaag cugacaaaca gccagaauuu ugacgaauac       60

augaaagcac ucggcgucgg guucgccacu agacaaguug gaaacgugac gaagcccacc      120

guaaucauuu cccaggaggg ugauaaagug gucauaagga cacuuucuac uuuuaagaau      180

accgaaaucu cauuccagcu gggcgaggaa uuugacgaga caaccgcgga ugaccggaac      240

uguaaaagug ugguuagcuu ggauggggac aaguuagugc acauucagaa gugggaugga      300

aaagagacua auuucguccg cgaaaucaag gacggcaaaa uggugaugac acugaccuuu      360

ggugauguag uugcugugcg acauuaugag aaggccuga                             399


<210>  1530
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FABP7__Homo_sapiens__AAB87141

<400>  1530
augguggagg ccuucugcgc caccuggaag cugaccaaca gccagaacuu cgacgaguac       60

augaaggccc ugggcguggg cuucgccacc agacaggugg gcaacgugac caagcccacc      120

gugaucauca gccaggaggg cgacaaggug gugaucagaa cccugagcac cuucaagaac      180

accgagauca gcuuccagcu gggcgaggag uucgacgaga ccaccgccga cgacagaaac      240

ugcaagagcg uggugagccu ggacggcgac aagcuggugc acauccagaa gugggacggc      300

aaggagacca acuucgugag agagaucaag gacggcaaga uggugaugac ccugaccuuc      360

ggcgacgugg uggccgugag acacuacgag aaggccuga                             399


<210>  1531
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FABP7__Homo_sapiens__AAB87141

<400>  1531
augguggagg ccuucugcgc uaccuggaag cugacaaaca gccagaauuu ugacgaauac       60

augaaagccc ucggcgucgg guucgcgacg agacaaguug gaaacgugac caagcccaca      120

gugaucauuu cccaggaggg cgauaaaguc gugauccgga cccugucuac auuuaagaau      180

accgaaauua gcuuccagcu uggggaggaa uuugacgaga caaccgcuga ugaccgcaac      240

uguaaauccg uugugucucu ggauggagac aagcucgucc acauccagaa gugggauggc      300

aaagagacga auuucgugag agaaauuaag gacgggaaaa ugguuaugac ccugacauuu      360

ggagaugugg ucgccgugcg gcauuaugag aaggccuga                             399


<210>  1532
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FCGR3A_Version_1__Homo_sapiens__P08637

<400>  1532

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  1533
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1533
auguggcagc ugcuccuccc aacugcucug cuacuucuag uuucagcugg caugcggacu       60

gaagaucucc caaaggcugu gguguuccug gagccucaau gguacagggu gcucgagaag      120

gacaguguga cucugaagug ccagggagcc uacuccccug aggacaauuc cacacagugg      180

uuucacaaug agagccucau cucaagccag gccucgagcu acuucauuga cgcugccaca      240

gucgacgaca guggagagua caggugccag acaaaccucu ccacccucag ugacccggug      300

cagcuagaag uccauaucgg cuggcuguug cuccaggccc cucggugggu guucaaggag      360

gaagacccua uucaccugag gugucacagc uggaagaaca cugcucugca uaaggucaca      420

uauuuacaga auggcaaagg caggaaguau uuucaucaua auucugacuu cuacauucca      480

aaagccacac ucaaagacag cggcuccuac uucugcaggg ggcuuuuugg gaguaaaaau      540

gugucuucag agacugugaa caucaccauc acucaagguu uggcaguguc aaccaucuca      600

ucauucuuuc caccugggua ccaagucucu uucugcuugg ugaugguacu ccuuuuugca      660

guggacacag gacuauauuu cucugugaag acaaacauuc gaagcucaac aagagacugg      720

aaggaccaua aauuuaaaug gagaaaggac ccucaagaca aauga                      765


<210>  1534
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1534
auguggcagc ugcuccugcc caccgcccug cuccugcugg ugagcgccgg caugcgcacc       60

gaggaccucc cgaaggcggu cguguuccug gagccccagu gguaccgggu gcuggagaag      120

gacuccguca cgcucaagug ccagggggcc uacagccccg aggacaacuc cacccagugg      180

uuccacaacg agagccugau cuccagccag gccuccagcu acuucaucga cgccgccacc      240

guggacgacu ccggcgagua ccgcugccag accaaccuga gcacgcucuc cgaccccgug      300

cagcuggagg uccacaucgg guggcugcuc cugcaggcgc cgcggugggu guucaaggag      360

gaggacccca uccaccuccg cugccacagc uggaagaaca ccgcccugca caaggugacc      420

uaccugcaga acggcaaggg gcggaaguac uuccaccaca acuccgacuu cuacaucccc      480

aaggccaccc ugaaggacag cggcuccuac uucugccgcg gccucuucgg gagcaagaac      540

gucuccagcg agacggugaa caucaccauc acccagggcc uggccguguc caccaucagc      600

agcuucuucc cgcccgggua ccaggucucc uucugccugg ugauggugcu ccuguucgcg      660

gucgacacgg gccuguacuu cagcgugaag accaacaucc gguccagcac ccgcgacugg      720

aaggaccaca aguucaagug gcggaaggac ccccaggaca aguga                      765


<210>  1535
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1535
auguggcagc uccuccuccc caccgcccuc cuccuccucg ucuccgccgg caugcgcacc       60

gaggaccucc ccaaggccgu cgucuuccuc gagccccagu gguaccgcgu ccucgagaag      120

gacuccguca cccucaagug ccagggcgcc uacucccccg aggacaacuc cacccagugg      180

uuccacaacg agucccucau cuccucccag gccuccuccu acuucaucga cgccgccacc      240

gucgacgacu ccggcgagua ccgcugccag accaaccucu ccacccucuc cgaccccguc      300

cagcucgagg uccacaucgg cuggcuccuc cuccaggccc cccgcugggu cuucaaggag      360

gaggacccca uccaccuccg cugccacucc uggaagaaca ccgcccucca caaggucacc      420

uaccuccaga acggcaaggg ccgcaaguac uuccaccaca acuccgacuu cuacaucccc      480

aaggccaccc ucaaggacuc cggcuccuac uucugccgcg gccucuucgg cuccaagaac      540

gucuccuccg agaccgucaa caucaccauc acccagggcc ucgccgucuc caccaucucc      600

uccuucuucc cccccggcua ccaggucucc uucugccucg ucaugguccu ccucuucgcc      660

gucgacaccg gccucuacuu cuccgucaag accaacaucc gcuccuccac ccgcgacugg      720

aaggaccaca aguucaagug gcgcaaggac ccccaggaca aguga                      765


<210>  1536
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1536
auguggcagc ugcuccuucc caccgcccug uuguuacugg ugagcgcugg caugagaaca       60

gaggaccuac cuaaggcagu cguuuuccuc gaaccacaau gguacagggu gcuggagaaa      120

gauuccguaa cucuuaagug ccagggggcc uauucuccgg aagacaacuc aacgcagugg      180

uuucacaaug agagucugau cagcucccag gcgucuucgu acuucauuga ugcugccacc      240

guggacgauu caggagaaua ucggugucaa acaaacuuga gcacucucag ugaccccguc      300

cagcuggagg ugcauauagg uuggcugcuc uuacaggcac cucgcugggu uuuuaaagag      360

gaagauccaa uccaucugcg augccacucc uggaagaaua ccgcccuuca caaagugaca      420

uacuugcaga acggcaaggg gcguaaguau uuccaucaca auucugacuu uuacauuccc      480

aaagcuaccc ugaaggauag cggauccuau uucuguagag gccuauuugg uaguaaaaac      540

gucucaagcg agacugugaa uaucacaauu acccaagggc ucgcaguauc uacgaucucc      600

ucauucuuuc cuccaggaua ccagguuagc uucugccugg ugaugguccu ucuguuugcc      660

guggacacug gcuuguacuu cagugugaag accaacauaa ggucuuccac acgggauugg      720

aaagaccaca aguuuaagug gcgcaaagau ccccaggaca aguga                      765


<210>  1537
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1537
auguggcagc ugcugcugcc caccgcccug cugcugcugg ugagcgccgg caugagaacc       60

gaggaccugc ccaaggccgu gguguuccug gagccccagu gguacagagu gcuggagaag      120

gacagcguga cccugaagug ccagggcgcc uacagccccg aggacaacag cacccagugg      180

uuccacaacg agagccugau cagcagccag gccagcagcu acuucaucga cgccgccacc      240

guggacgaca gcggcgagua cagaugccag accaaccuga gcacccugag cgaccccgug      300

cagcuggagg ugcacaucgg cuggcugcug cugcaggccc ccagaugggu guucaaggag      360

gaggacccca uccaccugag augccacagc uggaagaaca ccgcccugca caaggugacc      420

uaccugcaga acggcaaggg cagaaaguac uuccaccaca acagcgacuu cuacaucccc      480

aaggccaccc ugaaggacag cggcagcuac uucugcagag gccuguucgg cagcaagaac      540

gugagcagcg agaccgugaa caucaccauc acccagggcc uggccgugag caccaucagc      600

agcuucuucc cccccggcua ccaggugagc uucugccugg ugauggugcu gcuguucgcc      660

guggacaccg gccuguacuu cagcgugaag accaacauca gaagcagcac cagagacugg      720

aaggaccaca aguucaagug gagaaaggac ccccaggaca aguga                      765


<210>  1538
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FCGR3A_Version_1__Homo_sapiens__CAA36870

<400>  1538
auguggcagc ugcuccugcc caccgcccuu cugcuccugg ugagcgcugg caugagaaca       60

gaggaccuuc cuaaggccgu cguuuuccug gaaccgcaau gguaccgggu gcucgagaaa      120

gauuccguga cgcugaagug ccagggggcg uauucucccg aagacaacag cacccagugg      180

uuucacaaug agucccugau cucuagccag gcuuccucuu acuucauuga ugccgccaca      240

gucgacgaua gcggagaaua ucgcugucaa accaaccucu ccacacugag cgacccugug      300

cagcuugagg uucauaucgg cuggcugcuc cugcaggcuc ccagaugggu guuuaaagag      360

gaagauccua uucaccuucg gugccauucu uggaagaaua ccgcccugca caaagucaca      420

uaccuccaga acgggaaggg acgcaaguau uuccaucaca auuccgacuu uuacaucccc      480

aaagcuaccc ugaaggauag cggcucuuau uucuguagag ggcuguuugg auccaaaaac      540

gugagcucug agacgguuaa uauuaccauc acacaaggcc ucgccguguc caccaucagc      600

uccuucuuuc cuccgggcua ccaggucucu uucugccugg ugauggugcu ucuguuugcg      660

gucgacacag ggcucuacuu cagcguuaag accaacauuc gguccagcac gcgcgauugg      720

aaagaccaca aguuuaagug gagaaaagau ccccaggaca aguga                      765


<210>  1539
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1539

Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys Leu Val 
1               5                   10                  15      


Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys Pro Leu 
            20                  25                  30          


Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu 
        35                  40                  45              


Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val 
    50                  55                  60                  


Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr 
65                  70                  75                  80  


Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp 
                85                  90                  95      


Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile 
            100                 105                 110         


Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn 
        115                 120                 125             


Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp 
    130                 135                 140                 


Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile 
145                 150                 155                 160 


His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr 
                165                 170                 175     


Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp 
            180                 185                 190         


Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys 
        195                 200                 205             


Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile 
    210                 215                 220                 


Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
225                 230                 235                 240 


Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala 
                245                 250                 255     


Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser 
            260                 265                 270         


Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln 
        275                 280                 285             


Asp Lys 
    290 


<210>  1540
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1540
auggguggag gggcugggga aaggcuguuu acuuccuccu gucuagucgg uuuggucccu       60

uuagggcucc ggauaucuuu ggugacuugu ccacuccagu guggcaucau guggcagcug      120

cuccucccaa cugcucugcu acuucuaguu ucagcuggca ugcggacuga agaucuccca      180

aaggcugugg uguuccugga gccucaaugg uacagggugc ucgagaagga cagugugacu      240

cugaagugcc agggagccua cuccccugag gacaauucca cacagugguu ucacaaugag      300

agccucaucu caagccaggc cucgagcuac uucauugacg cugccacagu cgacgacagu      360

ggagaguaca ggugccagac aaaccucucc acccucagug acccggugca gcuagaaguc      420

cauaucggcu ggcuguugcu ccaggccccu cggugggugu ucaaggagga agacccuauu      480

caccugaggu gucacagcug gaagaacacu gcucugcaua aggucacaua uuuacagaau      540

ggcaaaggca ggaaguauuu ucaucauaau ucugacuucu acauuccaaa agccacacuc      600

aaagacagcg gcuccuacuu cugcaggggg cuuuuuggga guaaaaaugu gucuucagag      660

acugugaaca ucaccaucac ucaagguuug gcagugucaa ccaucucauc auucuuucca      720

ccuggguacc aagucucuuu cugcuuggug augguacucc uuuuugcagu ggacacagga      780

cuauauuucu cugugaagac aaacauucga agcucaacaa gagacuggaa ggaccauaaa      840

uuuaaaugga gaaaggaccc ucaagacaaa uga                                   873


<210>  1541
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1541
augggcgggg gcgccgggga gcgccuguuc accagcuccu gccucguggg ccuggucccc       60

cuggggcucc ggaucagccu ggugaccugc ccccugcagu gcggcaucau guggcagcuc      120

cugcugccca cggcccuccu gcugcucgug uccgcgggca ugcgcaccga ggaccugccc      180

aaggccgucg uguuccugga gccccagugg uaccgggugc ucgagaagga cagcgucacc      240

cugaagugcc agggggccua cuccccggag gacaacagca cccagugguu ccacaacgag      300

ucccugauca gcucccaggc cagcuccuac uucaucgacg ccgcgacggu ggacgacagc      360

ggcgaguacc gcugccagac caaccucucc acccugagcg accccgugca gcuggagguc      420

cacaucgggu ggcuccugcu gcaggcgccc cggugggugu ucaaggagga ggaccccauc      480

caccuccgcu gccacuccug gaagaacacc gcccugcaca aggugacgua ccugcagaac      540

ggcaaggggc ggaaguacuu ccaccacaac agcgacuucu acaucccgaa ggccacccuc      600

aaggacuccg gcagcuacuu cugccgcggc cuguucgggu ccaagaacgu cagcagcgag      660

accgugaaca ucaccaucac gcagggccug gccgugucca ccaucagcuc cuucuucccg      720

cccggguacc aggucagcuu cugccucgug auggugcugc uguucgccgu cgacaccggc      780

cucuacuucu ccgugaagac caacauccgg agcuccacgc gcgacuggaa ggaccacaag      840

uucaaguggc ggaaggaccc ccaggacaag uga                                   873


<210>  1542
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1542
augggcggcg gcgccggcga gcgccucuuc accuccuccu gccucgucgg ccucgucccc       60

cucggccucc gcaucucccu cgucaccugc ccccuccagu gcggcaucau guggcagcuc      120

cuccucccca ccgcccuccu ccuccucguc uccgccggca ugcgcaccga ggaccucccc      180

aaggccgucg ucuuccucga gccccagugg uaccgcgucc ucgagaagga cuccgucacc      240

cucaagugcc agggcgccua cucccccgag gacaacucca cccagugguu ccacaacgag      300

ucccucaucu ccucccaggc cuccuccuac uucaucgacg ccgccaccgu cgacgacucc      360

ggcgaguacc gcugccagac caaccucucc acccucuccg accccgucca gcucgagguc      420

cacaucggcu ggcuccuccu ccaggccccc cgcugggucu ucaaggagga ggaccccauc      480

caccuccgcu gccacuccug gaagaacacc gcccuccaca aggucaccua ccuccagaac      540

ggcaagggcc gcaaguacuu ccaccacaac uccgacuucu acauccccaa ggccacccuc      600

aaggacuccg gcuccuacuu cugccgcggc cucuucggcu ccaagaacgu cuccuccgag      660

accgucaaca ucaccaucac ccagggccuc gccgucucca ccaucuccuc cuucuucccc      720

cccggcuacc aggucuccuu cugccucguc augguccucc ucuucgccgu cgacaccggc      780

cucuacuucu ccgucaagac caacauccgc uccuccaccc gcgacuggaa ggaccacaag      840

uucaaguggc gcaaggaccc ccaggacaag uga                                   873


<210>  1543
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1543
augggcgggg gagccgguga gagacuguuc accagcuccu gccucguggg ccuugucccc       60

cugggguuga ggaucucuuu aguuacaugu ccucugcagu gcggaauuau guggcaacua      120

cuccugccaa cugcccuucu guugcucgug ucagcaggca ugcggacgga agaccugccg      180

aaggccguag uguuucugga gccccagugg uaccgcgucc ucgaaaaaga uagugugacc      240

uuaaaguguc agggugcgua uagcccugag gacaacucca cacagugguu ccacaaugaa      300

ucucugauau cgucacaagc uagcaguuac uuuaucgaug ccgcaacugu ugacgauucc      360

ggggaguauc gaugccagac caaccuuucu acauugagcg acccagugca gcuggagguc      420

cauauuggau ggcuacuccu gcaggcuccc cguugggugu ucaaagaaga ggauccuauc      480

caccuuagau gucauuccug gaagaauacc gcucugcaca aaguaacuua cuugcaaaac      540

ggcaagggca ggaaguauuu ucaucacaau ucagacuucu acauuccaaa agcaacacuc      600

aaggauagug ggagcuauuu uugccgggga cuguucgguu cuaaaaacgu uuccucagaa      660

accgugaaua ucacgauaac ucagggcuua gccgucagca ccaucaguuc uuucuuuccc      720

ccuggguacc agguguccuu uugucuggug augguccucc uuuucgcugu ugacacagga      780

cuguacuuua gcgugaagac uaacauucgc ucgucuacca gagauuggaa agaccacaag      840

uucaagugga ggaaagaucc acaggacaag uga                                   873


<210>  1544
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1544
augggcggcg gcgccggcga gagacuguuc accagcagcu gccugguggg ccuggugccc       60

cugggccuga gaaucagccu ggugaccugc ccccugcagu gcggcaucau guggcagcug      120

cugcugccca ccgcccugcu gcugcuggug agcgccggca ugagaaccga ggaccugccc      180

aaggccgugg uguuccugga gccccagugg uacagagugc uggagaagga cagcgugacc      240

cugaagugcc agggcgccua cagccccgag gacaacagca cccagugguu ccacaacgag      300

agccugauca gcagccaggc cagcagcuac uucaucgacg ccgccaccgu ggacgacagc      360

ggcgaguaca gaugccagac caaccugagc acccugagcg accccgugca gcuggaggug      420

cacaucggcu ggcugcugcu gcaggccccc agaugggugu ucaaggagga ggaccccauc      480

caccugagau gccacagcug gaagaacacc gcccugcaca aggugaccua ccugcagaac      540

ggcaagggca gaaaguacuu ccaccacaac agcgacuucu acauccccaa ggccacccug      600

aaggacagcg gcagcuacuu cugcagaggc cuguucggca gcaagaacgu gagcagcgag      660

accgugaaca ucaccaucac ccagggccug gccgugagca ccaucagcag cuucuucccc      720

cccggcuacc aggugagcuu cugccuggug auggugcugc uguucgccgu ggacaccggc      780

cuguacuuca gcgugaagac caacaucaga agcagcacca gagacuggaa ggaccacaag      840

uucaagugga gaaaggaccc ccaggacaag uga                                   873


<210>  1545
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FCGR3A_Version_2__Homo_sapiens__CCDS1232.1

<400>  1545
augggcgggg gagccggcga gagacuguuc accagcuccu gccucguggg gcuggucccc       60

cuuggacugc ggaucucucu cguuacaugu ccucugcagu gcggcauuau guggcaacuu      120

cugcucccga cggcucugcu gcuccuggug agcgccggga ugcgcaccga agaccuuccc      180

aaggcggugg ucuuucugga gccucagugg uacagagugc ucgaaaaaga uuccguuaca      240

cugaaguguc agggagcuua uucucccgag gacaacagca cccagugguu ccacaaugaa      300

ucccuuaucu cuagccaagc cuccagcuac uuuauugaug ccgcuacagu ggacgauucu      360

ggcgaguauc ggugccagac caaccugucc acacucagcg acccugucca gcuggaggug      420

cauaucggcu ggcugcuccu gcaggcuccc cgcuggguuu ucaaagaaga ggauccuauu      480

caccuuagau gucauucuug gaagaauacc gcccugcaca aagugacgua ccuccaaaac      540

gggaagggac ggaaguauuu ucaucacaau uccgacuucu acaucccgaa agccacccug      600

aaggauagcg gcucuuauuu uugccgcggg cuuuucggau ccaaaaacgu cagcuccgaa      660

acagugaaua ucaccauuac acagggccug gcggugucua ccaucagcuc cuuuuucccu      720

cccggguacc aggucagcuu uugucucguu auggugcugc uguucgccgu ggacacggga      780

cucuacuuuu cugucaagac aaacauuaga uccagcaccc gggauuggaa agaccacaag      840

uucaaguggc gcaaagaucc ccaggacaag uga                                   873


<210>  1546
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FGF5__Homo_sapiens__P12034

<400>  1546

Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Val Leu Glu Ile Phe Ala Val Ser Gln 
        115                 120                 125             


Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met 
    130                 135                 140                 


Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys 
145                 150                 155                 160 


Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser 
                165                 170                 175     


Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu 
            180                 185                 190         


Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro 
        195                 200                 205             


Gln His Ile Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln 
    210                 215                 220                 


Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro 
225                 230                 235                 240 


Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala Pro Arg Lys Asn Thr 
                245                 250                 255     


Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265             


<210>  1547
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FGF5__Homo_sapiens__AAH74858

<400>  1547
augagcuugu ccuuccuccu ccuccucuuc uucagccacc ugauccucag cgccugggcu       60

cacggggaga agcgucucgc ccccaaaggg caacccggac ccgcugccac ugauaggaac      120

ccuagaggcu ccagcagcag acagagcagc aguagcgcua ugucuuccuc uucugccucc      180

uccucccccg cagcuucucu gggcagccaa ggaaguggcu uggagcagag caguuuccag      240

uggagccccu cggggcgccg gaccggcagc cucuacugca gagugggcau cgguuuccau      300

cugcagaucu acccggaugg caaagucaau ggaucccacg aagccaauau guuaaguguu      360

uuggaaauau uugcuguguc ucaggggauu guaggaauac gaggaguuuu cagcaacaaa      420

uuuuuagcga ugucaaaaaa aggaaaacuc caugcaagug ccaaguucac agaugacugc      480

aaguucaggg agcguuuuca agaaaauagc uauaauaccu augccucagc aauacauaga      540

acugaaaaaa cagggcggga gugguaugug gcccugaaua aaagaggaaa agccaaacga      600

gggugcagcc cccggguuaa accccagcau aucucuaccc auuuucugcc aagauucaag      660

cagucggagc agccagaacu uucuuucacg guuacuguuc cugaaaagaa aaagccaccu      720

agcccuauca agccaaagau uccccuuucu gcaccucgga aaaauaccaa cucagugaaa      780

uacagacuca aguuucgcuu uggauaa                                          807


<210>  1548
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FGF5__Homo_sapiens__AAH74858

<400>  1548
augagccugu ccuuccuccu gcugcuguuc uucagccacc ugauccuguc cgccugggcc       60

cacggcgaga agcgccucgc gcccaagggg cagccgggcc ccgccgccac cgaccggaac      120

ccccgcggga gcuccagccg gcaguccagc uccagcgcca uguccagcuc cagcgccucc      180

agcucccccg cggccagccu gggcucccag gggagcggcc uggagcagag cuccuuccag      240

uggagcccgu ccggccgccg gaccgggagc cucuacugcc gcgugggcau cggguuccac      300

cuccagaucu accccgacgg caaggucaac gggucccacg aggccaacau gcugagcgug      360

cucgagaucu ucgccguguc ccagggcauc gucggcaucc gcgggguguu cagcaacaag      420

uuccuggcga uguccaagaa gggcaagcug cacgccagcg ccaaguucac ggacgacugc      480

aaguuccggg agcgguucca ggagaacucc uacaacaccu acgccagcgc cauccaccgc      540

accgagaaga ccgggcggga gugguacgug gcgcucaaca agcgcggcaa ggccaagcgg      600

ggcugcagcc cccgcgucaa gccccagcac aucuccacgc acuuccugcc gcgguucaag      660

caguccgagc agcccgagcu gagcuucacc gugaccgugc ccgagaagaa gaagcccccg      720

ucccccauca agcccaagau cccccucagc gccccgcgca agaacaccaa cuccgucaag      780

uaccggcuga aguuccgcuu cggguga                                          807


<210>  1549
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FGF5__Homo_sapiens__AAH74858

<400>  1549
augucccucu ccuuccuccu ccuccucuuc uucucccacc ucauccucuc cgccugggcc       60

cacggcgaga agcgccucgc ccccaagggc cagcccggcc ccgccgccac cgaccgcaac      120

ccccgcggcu ccuccucccg ccaguccucc uccuccgcca uguccuccuc cuccgccucc      180

uccucccccg ccgccucccu cggcucccag ggcuccggcc ucgagcaguc cuccuuccag      240

uggucccccu ccggccgccg caccggcucc cucuacugcc gcgucggcau cggcuuccac      300

cuccagaucu accccgacgg caaggucaac ggcucccacg aggccaacau gcucuccguc      360

cucgagaucu ucgccgucuc ccagggcauc gucggcaucc gcggcgucuu cuccaacaag      420

uuccucgcca uguccaagaa gggcaagcuc cacgccuccg ccaaguucac cgacgacugc      480

aaguuccgcg agcgcuucca ggagaacucc uacaacaccu acgccuccgc cauccaccgc      540

accgagaaga ccggccgcga gugguacguc gcccucaaca agcgcggcaa ggccaagcgc      600

ggcugcuccc cccgcgucaa gccccagcac aucuccaccc acuuccuccc ccgcuucaag      660

caguccgagc agcccgagcu cuccuucacc gucaccgucc ccgagaagaa gaagcccccc      720

ucccccauca agcccaagau cccccucucc gccccccgca agaacaccaa cuccgucaag      780

uaccgccuca aguuccgcuu cggcuga                                          807


<210>  1550
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FGF5__Homo_sapiens__AAH74858

<400>  1550
augagccugu ccuuccuccu ucuguuguuu uucucucacu uaauccuguc agccugggcu       60

cauggcgaaa agagacuagc acccaaaggg cagccuggac cagccgcgac cgacaggaac      120

ccgcggggua guagcucccg ccaaucuucg ucaagcgcua ugaguuccuc uagcgccucc      180

ucaagucccg cagccagccu cggcucucag ggguccggac uggaacagag cucauuucag      240

uggaguccuu cuggccgacg uacagguucc cuuuacugca gaguggggau uggauuccau      300

cugcaaauau auccagaugg caaggucaau ggcagccacg aggcuaacau guugucgguu      360

cucgaaaucu uugcaguguc ucaggggauu guaggaauca gggguguguu cuccaauaaa      420

uuucuggcca ugucaaagaa aggcaagcug cacgcuagug ccaaguucac ugacgauugu      480

aaauuucggg agcgcuucca ggaaaacagc uacaauacgu augcguccgc aauucauaga      540

accgagaaga cagggaggga gugguacguc gcccucaaca aacggggaaa ggcuaaacgc      600

ggcugcucuc cccgagugaa gccucagcac aucagcacuc acuuuuuacc aagauucaag      660

caaucagaac agcccgagcu gaguuuuacc guuacagugc cugagaaaaa gaaaccaccg      720

ucccccauaa agccuaaaau cccacuuagc gcccccagga agaauaccaa cucugucaaa      780

uaucgguuga aguuccguuu cgguuga                                          807


<210>  1551
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FGF5__Homo_sapiens__AAH74858

<400>  1551
augagccuga gcuuccugcu gcugcuguuc uucagccacc ugauccugag cgccugggcc       60

cacggcgaga agagacuggc ccccaagggc cagcccggcc ccgccgccac cgacagaaac      120

cccagaggca gcagcagcag acagagcagc agcagcgcca ugagcagcag cagcgccagc      180

agcagccccg ccgccagccu gggcagccag ggcagcggcc uggagcagag cagcuuccag      240

uggagcccca gcggcagaag aaccggcagc cuguacugca gagugggcau cggcuuccac      300

cugcagaucu accccgacgg caaggugaac ggcagccacg aggccaacau gcugagcgug      360

cuggagaucu ucgccgugag ccagggcauc gugggcauca gaggcguguu cagcaacaag      420

uuccuggcca ugagcaagaa gggcaagcug cacgccagcg ccaaguucac cgacgacugc      480

aaguucagag agagauucca ggagaacagc uacaacaccu acgccagcgc cauccacaga      540

accgagaaga ccggcagaga gugguacgug gcccugaaca agagaggcaa ggccaagaga      600

ggcugcagcc ccagagugaa gccccagcac aucagcaccc acuuccugcc cagauucaag      660

cagagcgagc agcccgagcu gagcuucacc gugaccgugc ccgagaagaa gaagcccccc      720

agccccauca agcccaagau cccccugagc gcccccagaa agaacaccaa cagcgugaag      780

uacagacuga aguucagauu cggcuga                                          807


<210>  1552
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FGF5__Homo_sapiens__AAH74858

<400>  1552
augagccugu ccuuccuccu gcuucuguuu uucucucacc ucauccugag cgccugggcc       60

cauggcgaaa agagacuugc ccccaaaggg cagccuggac cggcggcuac cgaccggaac      120

ccccgcggcu ccucuagcag acaauccucu agcuccgcca uguccucuuc cagcgccucu      180

uccagcccug cugccucucu ggggucccag ggaagcggcc ucgaacaguc cucuuuucag      240

uggagccccu ccgggcggcg cacaggaagc cuguacugca gagugggcau uggcuuccau      300

cugcaaaucu auccugaugg gaaggucaau ggaucucacg aggcuaacau gcucuccguu      360

cuggaaauuu uugccgugag ccagggcauc guggggauuc ggggagucuu cucuaauaaa      420

uuucuugcga ugagcaagaa aggcaagcug cacgccuccg cuaaguucac ggacgauugu      480

aaauuucgcg agagauucca ggaaaacucu uacaauaccu augccagcgc uauccaucgg      540

acagagaaga ccgggcgcga gugguacgug gcccucaaca aaagaggaaa ggcgaaacgg      600

ggcugcagcc cccgcguuaa gccucagcac aucagcacac acuuucugcc gagauucaag      660

caaucugaac agcccgagcu uuccuuuacc gugacagucc cugagaaaaa gaaacccccu      720

agccccauua agccgaaaau cccucugucu gcuccccgga agaauaccaa cuccgugaaa      780

uaucgccuca aguucagauu cggcuga                                          807


<210>  1553
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FGF5__Homo_sapiens__Q60518

<400>  1553

Met Ser Thr Arg Cys Gly Glu Ala Gly Arg Ala Arg Gly Thr Gln Pro 
1               5                   10                  15      


His Arg Gly Tyr Arg Ala Gln Asn Gln Pro Tyr Lys Met His Leu Gly 
            20                  25                  30          


Pro Pro Arg Leu Glu Glu 
        35              


<210>  1554
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FGF5__Homo_sapiens__AAB06462

<400>  1554
auguccaccc ggugcggcga ggcgggcaga gccagaggca cgcagccgca caggggcuac       60

agagcccaga aucagcccua caagaugcac uuaggacccc cgcggcugga agaauga         117


<210>  1555
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FGF5__Homo_sapiens__AAB06462

<400>  1555
augagcaccc gcugcggcga ggccgggcgg gcccgcggca cccagcccca ccggggguac       60

cgcgcgcaga accagcccua caagaugcac cugggcccgc cccggcucga ggaguga         117


<210>  1556
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FGF5__Homo_sapiens__AAB06462

<400>  1556
auguccaccc gcugcggcga ggccggccgc gcccgcggca cccagcccca ccgcggcuac       60

cgcgcccaga accagcccua caagaugcac cucggccccc cccgccucga ggaguga         117


<210>  1557
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FGF5__Homo_sapiens__AAB06462

<400>  1557
augagcacca gaugcggcga ggccgggagg gcucggggaa cacagcccca ccgcgguuac       60

cgagcacaaa accagccuua uaagaugcau cugggcccac cgcgucucga agaguga         117


<210>  1558
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FGF5__Homo_sapiens__AAB06462

<400>  1558
augagcacca gaugcggcga ggccggcaga gccagaggca cccagcccca cagaggcuac       60

agagcccaga accagcccua caagaugcac cugggccccc ccagacugga ggaguga         117


<210>  1559
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FGF5__Homo_sapiens__AAB06462

<400>  1559
augagcacca gaugcggcga ggccgggcgg gcucgcggaa cacagcccca cagaggcuac       60

cgggcccaaa accagccuua uaagaugcau cuggggccgc cccgccucga agaguga         117


<210>  1560
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FGFR2__Homo_sapiens__P21802

<400>  1560

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  1561
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FGFR2__Homo_sapiens__AAA59470

<400>  1561
auggucagcu ggggucguuu caucugccug gucgugguca ccauggcaac cuugucccug       60

gcccggcccu ccuucaguuu aguugaggau accacauuag agccagaaga gccaccaacc      120

aaauaccaaa ucucucaacc agaaguguac guggcugcgc caggggaguc gcuagaggug      180

cgcugccugu ugaaagaugc cgccgugauc aguuggacua aggauggggu gcacuugggg      240

cccaacaaua ggacagugcu uauuggggag uacuugcaga uaaagggcgc cacgccuaga      300

gacuccggcc ucuaugcuug uacugccagu aggacuguag acagugaaac uugguacuuc      360

auggugaaug ucacagaugc caucucaucc ggagaugaug aggaugacac cgauggugcg      420

gaagauuuug ucagugagaa caguaacaac aagagagcac cauacuggac caacacagaa      480

aagauggaaa agcggcucca ugcugugccu gcggccaaca cugucaaguu ucgcugccca      540

gccgggggga acccaaugcc aaccaugcgg uggcugaaaa acgggaagga guuuaagcag      600

gagcaucgca uuggaggcua caagguacga aaccagcacu ggagccucau uauggaaagu      660

guggucccau cugacaaggg aaauuauacc uguguggugg agaaugaaua cggguccauc      720

aaucacacgu accaccugga uguuguggag cgaucgccuc accggcccau ccuccaagcc      780

ggacugccgg caaaugccuc cacagugguc ggaggagacg uagaguuugu cugcaagguu      840

uacagugaug cccagcccca cauccagugg aucaagcacg uggaaaagaa cggcaguaaa      900

uacgggcccg acgggcugcc cuaccucaag guucucaagg ccgccggugu uaacaccacg      960

gacaaagaga uugagguucu cuauauucgg aauguaacuu uugaggacgc uggggaauau     1020

acgugcuugg cggguaauuc uauugggaua uccuuucacu cugcaugguu gacaguucug     1080

ccagcgccug gaagagaaaa ggagauuaca gcuuccccag acuaccugga gauagccauu     1140

uacugcauag gggucuucuu aaucgccugu auggugguaa cagucauccu gugccgaaug     1200

aagaacacga ccaagaagcc agacuucagc agccagccgg cugugcacaa gcugaccaaa     1260

cguauccccc ugcggagaca gguaacaguu ucggcugagu ccagcuccuc caugaacucc     1320

aacaccccgc uggugaggau aacaacacgc cucucuucaa cggcagacac ccccaugcug     1380

gcaggggucu ccgaguauga acuuccagag gacccaaaau gggaguuucc aagagauaag     1440

cugacacugg gcaagccccu gggagaaggu ugcuuugggc aaguggucau ggcggaagca     1500

gugggaauug acaaagacaa gcccaaggag gcggucaccg uggccgugaa gauguugaaa     1560

gaugaugcca cagagaaaga ccuuucugau cuggugucag agauggagau gaugaagaug     1620

auugggaaac acaagaauau cauaaaucuu cuuggagccu gcacacagga ugggccucuc     1680

uaugucauag uugaguaugc cucuaaaggc aaccuccgag aauaccuccg agcccggagg     1740

ccacccggga uggaguacuc cuaugacauu aaccguguuc cugaggagca gaugaccuuc     1800

aaggacuugg ugucaugcac cuaccagcug gccagaggca uggaguacuu ggcuucccaa     1860

aaauguauuc aucgagauuu agcagccaga aauguuuugg uaacagaaaa caaugugaug     1920

aaaauagcag acuuuggacu cgccagagau aucaacaaua uagacuauua caaaaagacc     1980

accaaugggc ggcuuccagu caaguggaug gcuccagaag cccuguuuga uagaguauac     2040

acucaucaga gugaugucug guccuucggg guguuaaugu gggagaucuu cacuuuaggg     2100

ggcucgcccu acccagggau ucccguggag gaacuuuuua agcugcugaa ggaaggacac     2160

agaauggaua agccagccaa cugcaccaac gaacuguaca ugaugaugag ggacuguugg     2220

caugcagugc ccucccagag accaacguuc aagcaguugg uagaagacuu ggaucgaauu     2280

cucacucuca caaccaauga ggaauacuug gaccucagcc aaccucucga acaguauuca     2340

ccuaguuacc cugacacaag aaguucuugu ucuucaggag augauucugu uuuuucucca     2400

gaccccaugc cuuacgaacc augccuuccu caguauccac acauaaacgg caguguuaaa     2460

acauga                                                                2466


<210>  1562
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FGFR2__Homo_sapiens__AAA59470

<400>  1562
auggugagcu ggggccgcuu caucugccug gucgugguga ccauggccac ccucucccug       60

gcccggccca gcuucucccu ggucgaggac acgacccucg agccggagga gccgcccacc      120

aaguaccaga ucagccagcc cgagguguac guggcggccc ccggggaguc ccuggagguc      180

cgcugccugc ucaaggacgc cgccgugauc agcuggacca aggacggcgu gcaccugggg      240

cccaacaacc ggacgguccu gaucggcgag uaccuccaga ucaagggggc cacgccccgc      300

gacuccggcc uguacgcgug caccgccagc cggaccgugg acuccgagac cugguacuuc      360

auggugaacg ucaccgacgc caucagcucc ggcgacgacg aggacgacac cgacggggcc      420

gaggacuucg ugagcgagaa cuccaacaac aagcgcgcgc ccuacuggac caacacggag      480

aagauggaga agcggcugca cgccgugccg gccgccaaca ccgucaaguu ccgcugcccc      540

gccggcggga accccaugcc caccaugcgg uggcucaaga acggcaagga guucaagcag      600

gagcaccgca ucgggggcua caaggugcgg aaccagcacu ggagccugau cauggagucc      660

guggucccga gcgacaaggg caacuacacg ugcguggugg agaacgagua cggguccauc      720

aaccacaccu accaccugga cgucguggag cgcagccccc accggcccau ccuccaggcg      780

ggccugcccg ccaacgccuc caccgugguc gggggcgacg uggaguucgu cugcaaggug      840

uacagcgacg cccagccgca cauccagugg aucaagcacg uggagaagaa cggcagcaag      900

uacgggcccg acggccugcc cuaccucaag guccugaagg ccgcgggggu gaacaccacc      960

gacaaggaga ucgaggugcu guacauccgc aacgucacgu ucgaggacgc cggcgaguac     1020

acgugccucg ccgggaacuc caucggcauc agcuuccacu ccgccuggcu gaccgugcug     1080

cccgccccgg gccgggagaa ggagaucacc gcgagccccg acuaccucga gaucgccauc     1140

uacugcaucg ggguguuccu gaucgccugc auggucguga ccgugauccu gugccgcaug     1200

aagaacacca ccaagaagcc cgacuucucc agccagcccg ccguccacaa gcucaccaag     1260

cggaucccgc ugcgccgcca ggugacggug uccgccgaga gcuccagcuc caugaacagc     1320

aacacgcccc ugguccggau caccacccgg cucuccagca ccgcggacac ccccaugcug     1380

gccggcgugu ccgaguacga gcugcccgag gacccgaagu gggaguuccc ccgcgacaag     1440

cucacccugg ggaagccccu gggcgagggg ugcuucggcc agguggucau ggccgaggcc     1500

gugggcaucg acaaggacaa gccgaaggag gcggugaccg ucgccgugaa gaugcucaag     1560

gacgacgcca cggagaagga ccugagcgac cugguguccg agauggagau gaugaagaug     1620

aucgggaagc acaagaacau caucaaccuc cugggcgccu gcacccagga cgggccccug     1680

uacgucaucg uggaguacgc cagcaagggc aaccuccgcg aguaccugcg ggcgcgccgg     1740

ccgcccggga uggaguacuc cuacgacauc aaccgcgugc ccgaggagca gaugaccuuc     1800

aaggaccugg ucagcugcac cuaccagcuc gcccggggca uggaguaccu ggccagccag     1860

aagugcaucc accgcgaccu ggccgcccgg aacgugcucg ugaccgagaa caacgucaug     1920

aagaucgcgg acuucggccu ggcccgcgac aucaacaaca ucgacuacua caagaagacg     1980

accaacgggc ggcugcccgu gaaguggaug gcccccgagg cccuguucga ccgcguguac     2040

acccaccagu ccgacgucug gagcuucggc gugcucaugu gggagaucuu cacccucggg     2100

ggcucccccu acccgggcau ccccguggag gagcuguuca agcugcugaa ggaggggcac     2160

cggauggaca agcccgccaa cugcacgaac gagcuguaca ugaugaugcg cgacugcugg     2220

cacgcggucc ccagccagcg gccgaccuuc aagcagcucg uggaggaccu ggaccgcauc     2280

cugacccuca ccacgaacga ggaguaccug gaccuguccc agccccucga gcaguacagc     2340

cccuccuacc ccgacacccg gagcuccugc agcuccggcg acgacagcgu guucuccccg     2400

gaccccaugc ccuacgagcc cugccugccg caguaccccc acaucaacgg gagcgucaag     2460

accuga                                                                2466


<210>  1563
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FGFR2__Homo_sapiens__AAA59470

<400>  1563
auggucuccu ggggccgcuu caucugccuc gucgucguca ccauggccac ccucucccuc       60

gcccgccccu ccuucucccu cgucgaggac accacccucg agcccgagga gccccccacc      120

aaguaccaga ucucccagcc cgaggucuac gucgccgccc ccggcgaguc ccucgagguc      180

cgcugccucc ucaaggacgc cgccgucauc uccuggacca aggacggcgu ccaccucggc      240

cccaacaacc gcaccguccu caucggcgag uaccuccaga ucaagggcgc caccccccgc      300

gacuccggcc ucuacgccug caccgccucc cgcaccgucg acuccgagac cugguacuuc      360

auggucaacg ucaccgacgc caucuccucc ggcgacgacg aggacgacac cgacggcgcc      420

gaggacuucg ucuccgagaa cuccaacaac aagcgcgccc ccuacuggac caacaccgag      480

aagauggaga agcgccucca cgccgucccc gccgccaaca ccgucaaguu ccgcugcccc      540

gccggcggca accccaugcc caccaugcgc uggcucaaga acggcaagga guucaagcag      600

gagcaccgca ucggcggcua caagguccgc aaccagcacu ggucccucau cauggagucc      660

gucguccccu ccgacaaggg caacuacacc ugcgucgucg agaacgagua cggcuccauc      720

aaccacaccu accaccucga cgucgucgag cgcucccccc accgccccau ccuccaggcc      780

ggccuccccg ccaacgccuc caccgucguc ggcggcgacg ucgaguucgu cugcaagguc      840

uacuccgacg cccagcccca cauccagugg aucaagcacg ucgagaagaa cggcuccaag      900

uacggccccg acggccuccc cuaccucaag guccucaagg ccgccggcgu caacaccacc      960

gacaaggaga ucgagguccu cuacauccgc aacgucaccu ucgaggacgc cggcgaguac     1020

accugccucg ccggcaacuc caucggcauc uccuuccacu ccgccuggcu caccguccuc     1080

cccgcccccg gccgcgagaa ggagaucacc gccucccccg acuaccucga gaucgccauc     1140

uacugcaucg gcgucuuccu caucgccugc auggucguca ccgucauccu cugccgcaug     1200

aagaacacca ccaagaagcc cgacuucucc ucccagcccg ccguccacaa gcucaccaag     1260

cgcauccccc uccgccgcca ggucaccguc uccgccgagu ccuccuccuc caugaacucc     1320

aacacccccc ucguccgcau caccacccgc cucuccucca ccgccgacac ccccaugcuc     1380

gccggcgucu ccgaguacga gcuccccgag gaccccaagu gggaguuccc ccgcgacaag     1440

cucacccucg gcaagccccu cggcgagggc ugcuucggcc aggucgucau ggccgaggcc     1500

gucggcaucg acaaggacaa gcccaaggag gccgucaccg ucgccgucaa gaugcucaag     1560

gacgacgcca ccgagaagga ccucuccgac cucgucuccg agauggagau gaugaagaug     1620

aucggcaagc acaagaacau caucaaccuc cucggcgccu gcacccagga cggcccccuc     1680

uacgucaucg ucgaguacgc cuccaagggc aaccuccgcg aguaccuccg cgcccgccgc     1740

ccccccggca uggaguacuc cuacgacauc aaccgcgucc ccgaggagca gaugaccuuc     1800

aaggaccucg ucuccugcac cuaccagcuc gcccgcggca uggaguaccu cgccucccag     1860

aagugcaucc accgcgaccu cgccgcccgc aacguccucg ucaccgagaa caacgucaug     1920

aagaucgccg acuucggccu cgcccgcgac aucaacaaca ucgacuacua caagaagacc     1980

accaacggcc gccuccccgu caaguggaug gcccccgagg cccucuucga ccgcgucuac     2040

acccaccagu ccgacgucug guccuucggc guccucaugu gggagaucuu cacccucggc     2100

ggcucccccu accccggcau ccccgucgag gagcucuuca agcuccucaa ggagggccac     2160

cgcauggaca agcccgccaa cugcaccaac gagcucuaca ugaugaugcg cgacugcugg     2220

cacgccgucc ccucccagcg ccccaccuuc aagcagcucg ucgaggaccu cgaccgcauc     2280

cucacccuca ccaccaacga ggaguaccuc gaccucuccc agccccucga gcaguacucc     2340

cccuccuacc ccgacacccg cuccuccugc uccuccggcg acgacuccgu cuucuccccc     2400

gaccccaugc ccuacgagcc cugccucccc caguaccccc acaucaacgg cuccgucaag     2460

accuga                                                                2466


<210>  1564
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FGFR2__Homo_sapiens__AAA59470

<400>  1564
auggugagcu ggggcagauu caucugccug gucguuguga ccauggccac acucucccuu       60

gcuaggcccu cuuuuucacu gguagaggac acuacguugg aaccugagga accaccgacc      120

aaguaccaga uuagucaacc cgagguguau gucgcagccc cuggggaauc cuuagaggug      180

cggugucugc uaaaagaugc ggcuguuaua uccuggacaa aggacggagu gcaccucggu      240

ccaaacaauc gcacuguccu gaucggcgag uaccuucaga uuaaaggggc cacaccccga      300

gauucuggac uguaugcaug caccgccucg cguaccgugg acucagaaac uugguacuuc      360

augguaaacg uuacagaugc uaucagcagu ggcgacgaug aggacgauac cgacggugca      420

gaagauuuug uguccgaaaa uucuaacaau aagagagccc cuuauuggac gaacacugag      480

aaaauggaaa agagguugca ugcuguccca gccgcgaaua ccgugaaguu ccgguguccc      540

gcagggggaa acccuaugcc aacaaugcgc uggcucaaaa auggcaagga guuuaaacag      600

gaacacagaa uuggcgggua caaggugagg aaccagcauu ggagccugau cauggagucc      660

gucguuccgu cagacaaagg aaauuauacu ugcgugguag aaaacgagua cgguaguaua      720

aaucacaccu accaucugga uguggucgag cggagccccc accgcccuau ccuccaagcc      780

ggcuuaccag cuaacgccuc uacagugguu gggggagacg uggaguucgu cuguaaggug      840

uauuccgacg cacagcccca cauucagugg aucaagcaug uagagaaaaa uggcucaaag      900

uacgguccug augggcugcc auaucuuaaa guuuugaagg cugccggagu gaacaccacg      960

gacaaagaaa uugagguccu guacauccga aacgugacuu uugaagaugc gggcgaguau     1020

acaugccuag ccggcaauag cauagggauu aguuuccacu cugcauggcu caccguccug     1080

cccgcuccgg gaagagagaa ggaaaucacu gccuccccug acuaccuuga gauugcuauc     1140

uauuguaucg guguguuucu gauugccugc augguuguga caguaauauu guguaggaug     1200

aaaaacacca cgaagaagcc cgauuucagc ucgcagccag caguccauaa acucaccaag     1260

cggaucccuc ugcgucgcca agugacaguu ucugccgaau ccucaaguag caugaauagc     1320

aacacucccu uagugagaau uaccacaagg cugucuagca cugcugacac cccaaugcuc     1380

gcgggcgucu cagaguacga acuucccgag gauccuaaau gggaguuucc acgggacaag     1440

cugacauugg ggaaaccgcu aggagaaggc ugcuucgguc aggugguaau ggcagaggcc     1500

guggggaucg auaaggacaa gcccaaagaa gcuguuaccg ucgccgugaa gaugcugaaa     1560

gaugacgcaa cugagaagga ccucagugau cugguguccg agauggaaau gaugaaaaug     1620

auaggcaagc acaagaauau uaucaaccuu cugggagccu guacgcagga cggcccuuug     1680

uacgucaucg uugaguaugc uagcaaaggg aaucuccgag aauaccugcg cgccagaagg     1740

ccacccggaa uggaguauuc uuacgauauu aaccgggugc cugaggaaca gaugacauuu     1800

aaggacuuag ugucaugcac cuaucaacug gcacgcggua uggaguaccu agcgagucag     1860

aaaugcaucc acagagaucu cgcugccagg aauguacugg ucacugaaaa caaugugaug     1920

aagauugcag acuucggccu ugcccgugau auaaacaaua ucgacuauua caaaaagacc     1980

acaaacgggc gguugccagu uaaguggaug gcucccgagg cccuguucga ucgaguguac     2040

acccaucaga gcgacgucug guccuuugga gugcucaugu gggaaauuuu cacucugggc     2100

gguucuccgu auccugggau cccaguugag gaacuuuuua aacuguugaa ggagggccac     2160

agaauggaua aacccgcaaa uuguacaaac gagcucuaca ugaugaugag ggacugcugg     2220

caugcugugc cuucgcaacg ccccacguuc aagcagcugg uagaagauuu agaccggauc     2280

cugacccuaa cuacaaacga ggaauaucuc gaccugagcc agccacuuga gcaguacucc     2340

ccuucauauc ccgauaccag aaguucuugu agcuccggag acgauucagu cuuuagccca     2400

gacccgaugc cuuacgaacc cugcuugcca caauaucccc acauuaaugg cucugugaaa     2460

acauga                                                                2466


<210>  1565
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FGFR2__Homo_sapiens__AAA59470

<400>  1565
auggugagcu ggggcagauu caucugccug guggugguga ccauggccac ccugagccug       60

gccagaccca gcuucagccu gguggaggac accacccugg agcccgagga gccccccacc      120

aaguaccaga ucagccagcc cgagguguac guggccgccc ccggcgagag ccuggaggug      180

agaugccugc ugaaggacgc cgccgugauc agcuggacca aggacggcgu gcaccugggc      240

cccaacaaca gaaccgugcu gaucggcgag uaccugcaga ucaagggcgc cacccccaga      300

gacagcggcc uguacgccug caccgccagc agaaccgugg acagcgagac cugguacuuc      360

auggugaacg ugaccgacgc caucagcagc ggcgacgacg aggacgacac cgacggcgcc      420

gaggacuucg ugagcgagaa cagcaacaac aagagagccc ccuacuggac caacaccgag      480

aagauggaga agagacugca cgccgugccc gccgccaaca ccgugaaguu cagaugcccc      540

gccggcggca accccaugcc caccaugaga uggcugaaga acggcaagga guucaagcag      600

gagcacagaa ucggcggcua caaggugaga aaccagcacu ggagccugau cauggagagc      660

guggugccca gcgacaaggg caacuacacc ugcguggugg agaacgagua cggcagcauc      720

aaccacaccu accaccugga cgugguggag agaagccccc acagacccau ccugcaggcc      780

ggccugcccg ccaacgccag caccguggug ggcggcgacg uggaguucgu gugcaaggug      840

uacagcgacg cccagcccca cauccagugg aucaagcacg uggagaagaa cggcagcaag      900

uacggccccg acggccugcc cuaccugaag gugcugaagg ccgccggcgu gaacaccacc      960

gacaaggaga ucgaggugcu guacaucaga aacgugaccu ucgaggacgc cggcgaguac     1020

accugccugg ccggcaacag caucggcauc agcuuccaca gcgccuggcu gaccgugcug     1080

cccgcccccg gcagagagaa ggagaucacc gccagccccg acuaccugga gaucgccauc     1140

uacugcaucg gcguguuccu gaucgccugc auggugguga ccgugauccu gugcagaaug     1200

aagaacacca ccaagaagcc cgacuucagc agccagcccg ccgugcacaa gcugaccaag     1260

agaauccccc ugagaagaca ggugaccgug agcgccgaga gcagcagcag caugaacagc     1320

aacacccccc uggugagaau caccaccaga cugagcagca ccgccgacac ccccaugcug     1380

gccggcguga gcgaguacga gcugcccgag gaccccaagu gggaguuccc cagagacaag     1440

cugacccugg gcaagccccu gggcgagggc ugcuucggcc agguggugau ggccgaggcc     1500

gugggcaucg acaaggacaa gcccaaggag gccgugaccg uggccgugaa gaugcugaag     1560

gacgacgcca ccgagaagga ccugagcgac cuggugagcg agauggagau gaugaagaug     1620

aucggcaagc acaagaacau caucaaccug cugggcgccu gcacccagga cggcccccug     1680

uacgugaucg uggaguacgc cagcaagggc aaccugagag aguaccugag agccagaaga     1740

ccccccggca uggaguacag cuacgacauc aacagagugc ccgaggagca gaugaccuuc     1800

aaggaccugg ugagcugcac cuaccagcug gccagaggca uggaguaccu ggccagccag     1860

aagugcaucc acagagaccu ggccgccaga aacgugcugg ugaccgagaa caacgugaug     1920

aagaucgccg acuucggccu ggccagagac aucaacaaca ucgacuacua caagaagacc     1980

accaacggca gacugcccgu gaaguggaug gcccccgagg cccuguucga cagaguguac     2040

acccaccaga gcgacgugug gagcuucggc gugcugaugu gggagaucuu cacccugggc     2100

ggcagccccu accccggcau ccccguggag gagcuguuca agcugcugaa ggagggccac     2160

agaauggaca agcccgccaa cugcaccaac gagcuguaca ugaugaugag agacugcugg     2220

cacgccgugc ccagccagag acccaccuuc aagcagcugg uggaggaccu ggacagaauc     2280

cugacccuga ccaccaacga ggaguaccug gaccugagcc agccccugga gcaguacagc     2340

cccagcuacc ccgacaccag aagcagcugc agcagcggcg acgacagcgu guucagcccc     2400

gaccccaugc ccuacgagcc cugccugccc caguaccccc acaucaacgg cagcgugaag     2460

accuga                                                                2466


<210>  1566
<211>  2466
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FGFR2__Homo_sapiens__AAA59470

<400>  1566
auggugagcu ggggcagauu caucugccug gucguuguga ccauggccac acucucccug       60

gcucggcccu cuuuuagccu uguggaggac acgacccugg aaccugagga accgcccaca      120

aaguaccaga uuucccaacc ugaggucuau guggccgcgc ccggggaauc ucucgagguu      180

cgcugucugc uuaaagaugc ugccgugauc agcuggacca aggacggagu ccaccugggc      240

ccuaacaaua gaacagugcu cauuggggag uaccugcaga ucaaaggagc cacaccccgg      300

gauuccggcc uguaugcuug caccgccucu cgcaccguug acagcgaaac gugguacuuc      360

auggugaacg ucaccgaugc uauuuccagc ggggacgaug aggacgauac agacggagcc      420

gaagauuuug ugucugaaaa uuccaacaau aagagagcgc cuuauuggac caacacagag      480

aaaauggaaa agcggcucca ugccgugccg gcugccaaua ccgucaaguu ccgcuguccc      540

gcuggcggca acccuaugcc cacgaugaga uggcugaaaa augggaagga guuuaaacag      600

gaacaccgga ucggaggcua caagguucgc aaccagcauu ggagccuuau cauggagucu      660

guggugccuu ccgacaaagg gaauuauaca ugcgucgugg aaaacgagua cggaagcauu      720

aaucacaccu accaucugga uguuguggag agaucucccc accggccgau ccuccaagcc      780

ggccugccug cgaacgccuc cacagucguu gggggagacg uggaguucgu guguaagguc      840

uauagcgacg cucagcccca cauucagugg aucaagcaug uggagaaaaa uggcuccaag      900

uacggcccug augggcuucc cuaucugaaa guccucaagg ccgcuggagu gaacaccacc      960

gacaaagaaa uugagguucu guacauccgc aacgugacau uugaagaugc cggcgaguau     1020

acgugccugg ccggaaauuc uauuggaauc agcuuccacu ccgcuuggcu caccguccug     1080

cccgcgccug gcagagagaa ggaaaucaca gccagcccgg acuaccuuga gauugcuauc     1140

uauuguauug ggguguuucu gaucgccugc augguuguga ccgucauucu cugucggaug     1200

aaaaacacaa ccaagaagcc cgauuucucu ucccagccug ccgugcauaa acugacgaag     1260

cgcauccccc uuagacggca agugacaguu agcgcugaau cuagcuccuc uaugaauagc     1320

aacaccccuc uggucagaau caccacacgc cucuccagca ccgccgacac acccaugcug     1380

gcgggagugu cugaguacga acugccggag gauccuaaau gggaguuucc ccgggacaag     1440

cucacgcugg gcaaaccucu uggcgaaggg ugcuucggac agguggucau ggcugaggcc     1500

gugggcauug auaaggacaa gcccaaagaa gccguuaccg uggcugucaa gaugcugaaa     1560

gaugacgcca cagagaagga ccucuccgau cuggugagcg agauggaaau gaugaaaaug     1620

aucgggaagc acaagaauau uaucaaccuu cugggagcuu guacccagga cggcccucuc     1680

uacguuauug uggaguaugc cucuaaaggg aaucugagag aauaccugcg cgcgcggaga     1740

cccccgggca uggaguauuc cuacgauauc aaccgcgucc cugaggaaca gaugacauuu     1800

aaggaccucg ugagcugcac cuaucaacug gcccggggaa uggaguaccu ugcuucccag     1860

aaaugcaucc acagagaucu ggccgcucgc aauguucucg ugacggaaaa caaugucaug     1920

aagauugccg acuucggccu ggcgcgggau aucaacaaua uugacuauua caaaaagacc     1980

acaaacggga gacugcccgu gaaguggaug gcccccgagg cucuuuucga ucgcguguac     2040

acccaucagu cugacgucug gagcuuugga guucucaugu gggaaaucuu cacacugggc     2100

ggguccccuu auccggggau ucccguggag gaacuguuua aacuccugaa ggagggccac     2160

cggauggaua aaccugccaa uuguaccaac gagcuuuaca ugaugaugag agacugcugg     2220

caugcugugc ccucucaacg gccuacguuc aagcagcugg ucgaagaucu cgaccgcauc     2280

cugacacuga ccacaaacga ggaauaucuu gaccucagcc agccccugga gcaguacucc     2340

ccuagcuauc ccgauaccag aucuuccugu agcucugggg acgauuccgu guuuagcccg     2400

gacccuaugc ccuacgaacc uugccugccc caauauccgc acauuaaugg cucuguuaaa     2460

accuga                                                                2466


<210>  1567
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A0A024R5I6

<400>  1567

Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr 
            20                  25                  30          


Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg 
        35                  40                  45              


Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly 
    50                  55                  60                  


Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu 
                85                  90                  95      


Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly 
            100                 105                 110         


Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser 
        115                 120                 125             


Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu 
    130                 135                 140                 


Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val 
145                 150                 155                 160 


Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu 
                165                 170                 175     


Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu 
            180                 185                 190         


Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu 
        195                 200                 205             


Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro 
    210                 215                 220                 


Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys 
225                 230                 235                 240 


Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr 
                245                 250                 255     


Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro 
            260                 265                 270         


Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln 
        275                 280                 285             


Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala 
    290                 295                 300                 


Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg 
305                 310                 315                 320 


Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu 
                325                 330                 335     


Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile 
            340                 345                 350         


Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val 
        355                 360                 365             


Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro 
    370                 375                 380                 


Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu 
385                 390                 395                 400 


Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala 
                405                 410                 415     


Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val 
            420                 425                 430         


Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile 
        435                 440                 445             


Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu 
    450                 455                 460                 


Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala 
465                 470                 475                 480 


Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His 
                485                 490                 495     


Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His 
            500                 505                 510         


Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala 
        515                 520                 525             


Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala 
    530                 535                 540                 


Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr 
545                 550                 555                 560 


Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro 
                565                 570                 575     


Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly 
            580                 585                 590         


Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser 
        595                 600                 605             


His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly 
    610                 615                 620                 


Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val 
625                 630                 635 


<210>  1568
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAW74574

<400>  1568
auggccccgc cgcuccugcu gcugcugcug gccaguggag cggccgccug cccgcugccc       60

ugcgucugcc agaaccuguc cgagucgcuc agcacccucu gugcccaccg aggccugcug      120

uuugugccgc ccaacgugga ccggcgcaca guggagcugc ggcuggcuga caacuucauc      180

caggcccugg ggcccccuga cuuccgcaac augacgggac ugguggaccu gacacugucu      240

cgcaaugcca ucacccgcau uggggcccgc gccuuugggg accucgagag ccugcguucc      300

cuccaccuug acggcaacag gcugguggag cugggcaccg ggagccuccg gggccccguc      360

aaucugcagc accucauccu cagcggcaac cagcugggcc gcaucgcgcc gggagccuuc      420

gacgacuucc uagagagccu ggaggaccug gaccuguccu acaacaaccu ccggcaggug      480

cccugggccg gcaucggcgc caugccugcc cugcacaccc ucaaccugga ccauaaccuu      540

auugacgcac ugcccccagg cgccuucgcc cagcucgguc agcucucccg ccuggaccuc      600

accuccaacc gccuggccac gcuggcuccg gacccgcuuu ucucucgugg gcgugaugca      660

gaggccucuc ccgccccccu ggugcugagc uuuagcggga acccccugca cugcaacugu      720

gagcugcugu ggcugcggcg gcuggcgcgg ccggacgacc uggaaacgug cgccuccccg      780

cccggccugg ccggccgcua cuucugggca gugcccgagg gcgaguucuc cugugagccg      840

ccccucauug cccgccacac gcagcgccuc ugggugcugg aaggccagcg ggccacgcug      900

cggugccggg cccuggguga ccccgcgccu accaugcacu gggucggucc ugacgaccgg      960

uugguuggca acuccucccg agcccgggcu uuccccaacg ggaccuuaga gauuggggug     1020

accggcgcug gggacgcugg gggcuacacc ugcaucgcca ccaacccugc uggugaggcc     1080

acagcccgag uagaacugcg ggugcuggcc uugccccaug gugggaacag cagugccgag     1140

gggggccgcc ccgggcccuc ggacaucgcc gccuccgcuc gcacugcugc cgagggugag     1200

gggacgcugg agucugagcc agccgugcag gugacggagg ugaccgccac cucagggcug     1260

gugagcuggg gucccgggcg gccagccgac ccagugugga uguuccaaau ccaguacaac     1320

agcagcgaag augagacccu caucuaccgg auugucccag ccuccagcca ccacuuccug     1380

cugaagcacc ucguccccgg cgcugacuau gaccucugcc ugcuggccuu gucaccggcc     1440

gcugggcccu cugaccucac ggccaccagg cugcugggcu gugcccauuu cuccacgcug     1500

ccggccucgc cccugugcca cgcccugcag gcccacgugc ugggcgggac ccugaccgug     1560

gccguggggg gugugcuggu ggcugccuua cuggucuuca cuguggccuu gcugguucgg     1620

ggccgggggg ccggaaaugg ccgccucccc cucaagcuca gccacgucca gucccagacc     1680

aauggaggcc ccagccccac acccaaggcc cacccgccgc ggagcccccc gccccggccg     1740

cagcgcagcu gcucucugga ccugggagau gccgggugcu acgguuaugc caggcgccug     1800

ggaggagcuu gggcccgacg gagccacucu gugcaugggg ggcugcucgg ggcagggugc     1860

cgggggguag gaggcagcgc cgagcggcug gaagagagug ugguguga                  1908


<210>  1569
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAW74574

<400>  1569
auggccccgc cccugcuccu gcugcuccug gccagcggcg cggccgccug cccccugccc       60

ugcgugugcc agaaccucuc cgagagccug uccacccugu gcgcccaccg cgggcuccug      120

uucgugcccc cgaacgucga ccggcgcacc guggagcugc ggcucgccga caacuucauc      180

caggcgcugg gcccgcccga cuuccgcaac augacggggc uggucgaccu cacccugagc      240

cggaacgcca ucacccgcau cggcgcccgg gccuucgggg accuggaguc ccuccgcagc      300

cugcaccugg acggcaaccg gcucguggag cugggcaccg ggucccugcg cggccccgug      360

aaccuccagc accugauccu gagcgggaac cagcucggcc ggaucgcgcc cggggccuuc      420

gacgacuucc uggagucccu ggaggaccuc gaccugagcu acaacaaccu gcgccagguc      480

cccugggccg gcaucggcgc caugcccgcc cuccacacgc ugaaccugga ccacaaccuc      540

aucgacgcgc ugcccccggg ggccuucgcc cagcugggcc agcucucccg gcuggaccug      600

accagcaacc gccucgccac ccuggccccc gacccccugu ucucccgggg gcgcgacgcg      660

gaggccagcc ccgccccgcu cgugcugucc uucagcggca acccccugca cugcaacugc      720

gagcuccugu ggcugcggcg ccuggcccgg cccgacgacc ucgagaccug cgccuccccg      780

cccggccugg cggggcgcua cuucugggcc gugcccgagg gcgaguucag cugcgagccg      840

ccccugaucg cccggcacac gcagcgccuc uggguccugg aggggcagcg cgccacccug      900

cggugccgcg cccucggcga ccccgcgccc accaugcacu ggguggggcc cgacgaccgg      960

cuggugggca acuccagccg cgcccgggcc uuccccaacg gcacccugga gaucgggguc     1020

acgggcgccg gggacgcggg cggguacacg ugcaucgcca ccaaccccgc cggcgaggcc     1080

accgcccgcg uggagcuccg ggugcuggcg cugccccacg gcgggaacag cuccgccgag     1140

ggcgggcgcc ccggcccgag cgacaucgcc gccuccgccc ggaccgcggc cgagggggag     1200

ggcacccucg agagcgagcc cgccguccag gugaccgagg ugaccgccac guccggccug     1260

gucagcuggg ggcccggccg ccccgccgac ccggugugga uguuccagau ccaguacaac     1320

uccagcgagg acgagacccu gaucuaccgg aucgugcccg cguccagcca ccacuuccuc     1380

cugaagcacc ugguccccgg ggccgacuac gaccucugcc ugcuggcccu cucccccgcc     1440

gcgggcccga gcgaccugac cgccacccgc cugcucggcu gcgcccacuu cuccacgcug     1500

cccgccagcc cccugugcca cgcccuccag gcgcacgugc ucgggggcac ccugaccgug     1560

gccgucgggg gcgugcuggu cgccgcccug cugguguuca ccguggcccu ccugguccgg     1620

gggcgcggcg cgggcaacgg gcggcugccc cucaagcugu cccacgugca gagccagacg     1680

aacggcgggc cgucccccac ccccaaggcc cacccgcccc gcagcccgcc gccccggccc     1740

cagcgcuccu gcagccugga ccucggcgac gccgggugcu acggcuacgc ccggcgccug     1800

ggcggggccu gggcgcgccg gagccacucc gugcacggcg ggcugcucgg cgccgggugc     1860

cgcggcgucg gcgggagcgc cgagcggcug gaggaguccg ugguguga                  1908


<210>  1570
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAW74574

<400>  1570
auggcccccc cccuccuccu ccuccuccuc gccuccggcg ccgccgccug cccccucccc       60

ugcgucugcc agaaccucuc cgagucccuc uccacccucu gcgcccaccg cggccuccuc      120

uucguccccc ccaacgucga ccgccgcacc gucgagcucc gccucgccga caacuucauc      180

caggcccucg gcccccccga cuuccgcaac augaccggcc ucgucgaccu cacccucucc      240

cgcaacgcca ucacccgcau cggcgcccgc gccuucggcg accucgaguc ccuccgcucc      300

cuccaccucg acggcaaccg ccucgucgag cucggcaccg gcucccuccg cggccccguc      360

aaccuccagc accucauccu cuccggcaac cagcucggcc gcaucgcccc cggcgccuuc      420

gacgacuucc ucgagucccu cgaggaccuc gaccucuccu acaacaaccu ccgccagguc      480

cccugggccg gcaucggcgc caugcccgcc cuccacaccc ucaaccucga ccacaaccuc      540

aucgacgccc ucccccccgg cgccuucgcc cagcucggcc agcucucccg ccucgaccuc      600

accuccaacc gccucgccac ccucgccccc gacccccucu ucucccgcgg ccgcgacgcc      660

gaggccuccc ccgccccccu cguccucucc uucuccggca acccccucca cugcaacugc      720

gagcuccucu ggcuccgccg ccucgcccgc cccgacgacc ucgagaccug cgccuccccc      780

cccggccucg ccggccgcua cuucugggcc guccccgagg gcgaguucuc cugcgagccc      840

ccccucaucg cccgccacac ccagcgccuc uggguccucg agggccagcg cgccacccuc      900

cgcugccgcg cccucggcga ccccgccccc accaugcacu gggucggccc cgacgaccgc      960

cucgucggca acuccucccg cgcccgcgcc uuccccaacg gcacccucga gaucggcguc     1020

accggcgccg gcgacgccgg cggcuacacc ugcaucgcca ccaaccccgc cggcgaggcc     1080

accgcccgcg ucgagcuccg cguccucgcc cucccccacg gcggcaacuc cuccgccgag     1140

ggcggccgcc ccggccccuc cgacaucgcc gccuccgccc gcaccgccgc cgagggcgag     1200

ggcacccucg aguccgagcc cgccguccag gucaccgagg ucaccgccac cuccggccuc     1260

gucuccuggg gccccggccg ccccgccgac cccgucugga uguuccagau ccaguacaac     1320

uccuccgagg acgagacccu caucuaccgc aucguccccg ccuccuccca ccacuuccuc     1380

cucaagcacc ucguccccgg cgccgacuac gaccucugcc uccucgcccu cucccccgcc     1440

gccggccccu ccgaccucac cgccacccgc cuccucggcu gcgcccacuu cuccacccuc     1500

cccgccuccc cccucugcca cgcccuccag gcccacgucc ucggcggcac ccucaccguc     1560

gccgucggcg gcguccucgu cgccgcccuc cucgucuuca ccgucgcccu ccucguccgc     1620

ggccgcggcg ccggcaacgg ccgccucccc cucaagcucu cccacgucca gucccagacc     1680

aacggcggcc ccucccccac ccccaaggcc cacccccccc gcuccccccc cccccgcccc     1740

cagcgcuccu gcucccucga ccucggcgac gccggcugcu acggcuacgc ccgccgccuc     1800

ggcggcgccu gggcccgccg cucccacucc guccacggcg gccuccucgg cgccggcugc     1860

cgcggcgucg gcggcuccgc cgagcgccuc gaggaguccg ucgucuga                  1908


<210>  1571
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAW74574

<400>  1571
auggcacccc cucugcuccu ucuguuguua gcuagcggcg cagccgcgug cccacugccg       60

ugugugugcc agaaccuauc cgagucucuc ucaacccugu gugcucacag agggcuucug      120

uucguucccc cuaaugucga caggcggaca guggaauugc gccucgccga uaacuuuauc      180

caagcacugg gaccacccga cuuccgaaau augacugguc ugguagaucu cacguuaagu      240

cguaacgcca uuaccagaau aggcgcuagg gcauuugggg accuggagag ccuucggucc      300

uugcaucugg auggaaaucg ccuaguggaa cucggcacag guucucugag agggccuguc      360

aaccuucagc accugaucuu gucgggaaau cagcucggca ggauugcccc aggcgcuuuc      420

gacgauuuuc uggagucauu agaagaccug gaucucagcu acaacaaucu ucgccaggug      480

cccugggccg ggaucggagc gaugccugca cugcauacuu ugaaccuaga ccacaaucug      540

auugaugccc ucccaccggg ugcuuucgcc caacugggcc agcuuagucg gcuggacuug      600

accuccaacc gacucgcaac acuggcuccc gauccuuuau uuucuagagg gagggacgcc      660

gaggcgagcc cagcaccccu gguucuaucc uucucaggaa auccucucca uugcaacugu      720

gagcugcuuu gguugcggcg ucuggcccgc ccagacgauc ucgaaaccug cgcuaguccc      780

ccgggccugg ccgguagaua uuuuugggcu gugccugagg gggaguucag cugugaaccc      840

ccacuuaucg ccaggcacac ucagcggcug ugggucuugg agggacagcg agcaacacuc      900

cgcugcagag cccugggcga cccugcuccc accaugcacu gggugggccc agaugacagg      960

uuaguaggaa auucuucccg ggcgcgcgca uuucccaacg ggacgcugga aauagguguu     1020

acuggcgccg gggaugcugg aggcuacacc uguaucgcca caaacccugc cggugaggcc     1080

acugcuagag uggaacuaag gguccucgcc cugccacaug ggggcaauuc aagcgcagag     1140

ggaggccguc cggggcccag ugacauugcg gcuucugccc ggaccgcagc cgaaggagag     1200

gguacacuug aguccgaacc ugcugugcaa gugaccgagg ucacggccac uagcggcuug     1260

guuucguggg ggccaggacg acccgcagau ccugugugga uguuccagau ccaguauaac     1320

ucuuccgaag acgagacacu gauuuacaga aucguaccag cuucaaguca ccauuuucuc     1380

cugaagcacu uagugcccgg cgccgauuau gaccugugcc uuuuggcgcu cagcccggcc     1440

gcugguccuu ccgaucugac cgcaacuagg cuacuggggu gugcccacuu cucuacacuc     1500

ccagcuagcc cccugugcca ugcccuucag gcacacgucu ugggcggaac ccugacggug     1560

gcgguuggcg ggguguuagu cgccgcucuc cugguguuca ccguagcccu ucugguucgc     1620

ggacggggug caggcaaugg gagauugccu cucaaacugu cacaugugca aagucagaca     1680

aacggaggcc ccuccccaac uccuaaggcu caucccccaa ggagcccgcc uccccgccca     1740

cagcgaucuu gcucacuaga ccugggugac gccggguguu acggcuaugc acggcgucuc     1800

ggaggcgccu gggcuagaag gagucacagc guccacgggg gacugcuugg cgcggguugc     1860

cgcggggugg gaggcuccgc cgaacgguug gaggagucug ucguguga                  1908


<210>  1572
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAW74574

<400>  1572
auggcccccc cccugcugcu gcugcugcug gccagcggcg ccgccgccug cccccugccc       60

ugcgugugcc agaaccugag cgagagccug agcacccugu gcgcccacag aggccugcug      120

uucgugcccc ccaacgugga cagaagaacc guggagcuga gacuggccga caacuucauc      180

caggcccugg gcccccccga cuucagaaac augaccggcc ugguggaccu gacccugagc      240

agaaacgcca ucaccagaau cggcgccaga gccuucggcg accuggagag ccugagaagc      300

cugcaccugg acggcaacag acugguggag cugggcaccg gcagccugag aggccccgug      360

aaccugcagc accugauccu gagcggcaac cagcugggca gaaucgcccc cggcgccuuc      420

gacgacuucc uggagagccu ggaggaccug gaccugagcu acaacaaccu gagacaggug      480

cccugggccg gcaucggcgc caugcccgcc cugcacaccc ugaaccugga ccacaaccug      540

aucgacgccc ugccccccgg cgccuucgcc cagcugggcc agcugagcag acuggaccug      600

accagcaaca gacuggccac ccuggccccc gacccccugu ucagcagagg cagagacgcc      660

gaggccagcc ccgccccccu ggugcugagc uucagcggca acccccugca cugcaacugc      720

gagcugcugu ggcugagaag acuggccaga cccgacgacc uggagaccug cgccagcccc      780

cccggccugg ccggcagaua cuucugggcc gugcccgagg gcgaguucag cugcgagccc      840

ccccugaucg ccagacacac ccagagacug ugggugcugg agggccagag agccacccug      900

agaugcagag cccugggcga ccccgccccc accaugcacu gggugggccc cgacgacaga      960

cuggugggca acagcagcag agccagagcc uuccccaacg gcacccugga gaucggcgug     1020

accggcgccg gcgacgccgg cggcuacacc ugcaucgcca ccaaccccgc cggcgaggcc     1080

accgccagag uggagcugag agugcuggcc cugccccacg gcggcaacag cagcgccgag     1140

ggcggcagac ccggccccag cgacaucgcc gccagcgcca gaaccgccgc cgagggcgag     1200

ggcacccugg agagcgagcc cgccgugcag gugaccgagg ugaccgccac cagcggccug     1260

gugagcuggg gccccggcag acccgccgac cccgugugga uguuccagau ccaguacaac     1320

agcagcgagg acgagacccu gaucuacaga aucgugcccg ccagcagcca ccacuuccug     1380

cugaagcacc uggugcccgg cgccgacuac gaccugugcc ugcuggcccu gagccccgcc     1440

gccggcccca gcgaccugac cgccaccaga cugcugggcu gcgcccacuu cagcacccug     1500

cccgccagcc cccugugcca cgcccugcag gcccacgugc ugggcggcac ccugaccgug     1560

gccgugggcg gcgugcuggu ggccgcccug cugguguuca ccguggcccu gcuggugaga     1620

ggcagaggcg ccggcaacgg cagacugccc cugaagcuga gccacgugca gagccagacc     1680

aacggcggcc ccagccccac ccccaaggcc caccccccca gaagcccccc ccccagaccc     1740

cagagaagcu gcagccugga ccugggcgac gccggcugcu acggcuacgc cagaagacug     1800

ggcggcgccu gggccagaag aagccacagc gugcacggcg gccugcuggg cgccggcugc     1860

agaggcgugg gcggcagcgc cgagagacug gaggagagcg ugguguga                  1908


<210>  1573
<211>  1908
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAW74574

<400>  1573
auggcucccc cucugcuccu gcuucugcuc gccagcggcg ccgcggcuug cccgcugccc       60

ugugugugcc agaaccuuuc cgagucucug agcacccucu gugcccacag agggcugcug      120

uucgucccuc ccaauguuga ccggcgcaca guggaacuca gacuggccga uaacuuuauc      180

caagcucuug gaccucccga cuuccggaau augacgggcc ugguggaucu cacccugucc      240

cgcaacgcca uuacaagaau cggggcucgg gccuuuggag accuugaguc ucugcgcagc      300

cuccaucugg auggcaauag acuggucgaa cucgggaccg gaucccugcg gggcccugug      360

aaccuucagc accugauucu cucuggcaau cagcuggggc gcaucgcgcc gggagccuuc      420

gacgauuuuc uugagagccu ggaagaccuc gaucuguccu acaacaaucu gagacagguu      480

cccugggcug gcauuggggc caugccugcu cuccauacac ugaaccuuga ccacaaucug      540

aucgaugccc ugcccccugg agcguucgcc caacucggcc agcuuagccg gcuggaccuc      600

accucuaacc gccuggcuac acuggccccc gauccgcucu uuuccagagg gcgggacgcu      660

gaggccagcc cugcuccccu ggugcuuucu uucuccggaa auccucugca uugcaacugu      720

gagcuccugu ggcugcgcag acuugcccgg cccgacgauc ucgaaaccug cgcgucuccc      780

ccuggccugg ccggcagaua uuuuugggcu gucccggagg gggaguucag cugugaaccc      840

ccucugaucg cccgccacac gcagcggcuc ugggugcugg agggacagag agccacccuu      900

cgcugccggg cucugggcga ccccgccccu acaaugcacu ggguugggcc cgaugacaga      960

cucgugggaa auuccagccg cgcgcgggcu uuuccgaacg gcacccugga aauugggguc     1020

acaggagccg gcgaugccgg cggguacacc uguaucgcua cgaacccugc cggagaggcu     1080

acagccagag uggaacugcg cgugcuugcg cucccccaug gcgggaacuc cucugccgag     1140

ggaggccggc cugggcccag cgacauugcu gccuccgcua gaaccgccgc ggaaggcgag     1200

ggaacacugg agagcgaacc ugccguccaa guuaccgagg ugaccgcuac aucuggccug     1260

guguccuggg ggcccggacg cccggccgau ccugucugga uguuccagau ccaguauaau     1320

agcucugaag acgagacgcu cauuuaccgg aucgugcccg cuagcuccca ccauuuucug     1380

cuuaagcacc ugguucccgg cgccgauuau gaccucugcc ugcuggcccu uucuccugcu     1440

gcggggccga gcgaucucac cgccacaaga cugcugggau gugcucacuu cuccacccuc     1500

cccgccagcc cucugugcca ugcccuucag gcucacgugc ugggcgggac acucaccguc     1560

gccgugggcg gaguucuggu ggcggcucug cuugucuuca cgguggcccu ccugguccgg     1620

ggccgcgggg ccggaaaugg cagacugccc cucaaacugu cucaugugca aucccagaca     1680

aacgggggac cuagccccac cccuaaggcu caucccccgc ggucuccucc cccuagaccc     1740

cagcgcuccu gcagccuuga ccugggcgac gccggguguu acggcuaugc gcggagacuc     1800

ggaggcgcuu gggcccgcag aucccacucu guucacgggg gacugcuggg cgccgggugc     1860

cggggagugg gcgggagcgc ugaacgccuu gaggaguccg ucguguga                  1908


<210>  1574
<211>  1098
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A0A024RB01

<400>  1574

Met Pro Pro Arg Gln Pro Pro Arg Gln Ala Gly Gly Gly Leu Ser Arg 
1               5                   10                  15      


Glu Phe Gly Lys Leu Leu Pro Ala Leu Ser His Ser Pro Leu Gly Gly 
            20                  25                  30          


Leu Gly Ser Gly Ser Gly Ser Val Ala Pro Gly Gln Gly Arg Ala Gly 
        35                  40                  45              


Ala Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu 
    50                  55                  60                  


Arg Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu 
                85                  90                  95      


Ala Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser 
            100                 105                 110         


Val Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly 
        115                 120                 125             


Ala Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala 
    130                 135                 140                 


Val Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile 
145                 150                 155                 160 


Glu Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser 
                165                 170                 175     


Ser Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly 
            180                 185                 190         


Ala Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu 
        195                 200                 205             


Tyr Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr 
    210                 215                 220                 


Cys Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro 
225                 230                 235                 240 


Cys Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly 
                245                 250                 255     


Gly Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly 
            260                 265                 270         


Pro Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu 
        275                 280                 285             


Gln Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln 
    290                 295                 300                 


Gly Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr 
305                 310                 315                 320 


Leu Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu 
                325                 330                 335     


Asp Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val 
            340                 345                 350         


Thr Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly 
        355                 360                 365             


Glu Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val 
    370                 375                 380                 


Asn Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met 
385                 390                 395                 400 


Asp Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val 
                405                 410                 415     


Tyr Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu 
            420                 425                 430         


Thr Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu 
        435                 440                 445             


Gly Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro 
    450                 455                 460                 


Phe Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly 
465                 470                 475                 480 


Pro Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp 
                485                 490                 495     


Ala Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly 
            500                 505                 510         


Arg Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe 
        515                 520                 525             


Gly Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala 
    530                 535                 540                 


Ser Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg 
545                 550                 555                 560 


Ser Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe 
                565                 570                 575     


Cys Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr 
            580                 585                 590         


Val Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg 
        595                 600                 605             


Ala Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu 
    610                 615                 620                 


Ile Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu 
625                 630                 635                 640 


Arg Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala 
                645                 650                 655     


Leu Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu 
            660                 665                 670         


Arg Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala 
        675                 680                 685             


Gln Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu 
    690                 695                 700                 


Gln Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys 
705                 710                 715                 720 


Asn Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly 
                725                 730                 735     


Ala Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr 
            740                 745                 750         


Ser Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp 
        755                 760                 765             


Tyr Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn 
    770                 775                 780                 


Pro Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val 
785                 790                 795                 800 


Pro His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile 
                805                 810                 815     


Leu Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg 
            820                 825                 830         


Leu Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys 
        835                 840                 845             


Pro Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln 
    850                 855                 860                 


Pro Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu 
865                 870                 875                 880 


Leu Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu 
                885                 890                 895     


Ser Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg 
            900                 905                 910         


Val Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly 
        915                 920                 925             


Leu Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu 
    930                 935                 940                 


Ala Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys 
945                 950                 955                 960 


Pro Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His 
                965                 970                 975     


Gln Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys 
            980                 985                 990         


Thr Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala 
        995                 1000                1005            


Val Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu 
    1010                1015                1020                


Pro Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala 
1025                1030                1035                1040


Glu Gly Ser Tyr Gly Val Pro Leu Trp Ile Ile Ile Leu Ala Ile Leu 
                1045                1050                1055    


Phe Gly Leu Leu Leu Leu Gly Leu Leu Ile Tyr Ile Leu Tyr Lys Leu 
            1060                1065                1070        


Gly Phe Phe Lys Arg Ser Leu Pro Tyr Gly Thr Ala Met Glu Lys Ala 
        1075                1080                1085            


Gln Leu Lys Pro Pro Ala Thr Ser Asp Ala 
    1090                1095            


<210>  1575
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAW96782

<400>  1575
augccccccc gccagccccc ucggcaggcg gggggagggc ucagccggga guuuggcaaa       60

cuccuccccg cguugaguca uucgccucug ggagguuuag gaagcggcuc cgggucggug      120

gccccaggac agggaagagc gggcgcuaug gggagccgga cgccagaguc cccucuccac      180

gccgugcagc ugcgcugggg cccccggcgc cgacccccgc ugcugccgcu gcuguugcug      240

cugcugccgc cgccacccag ggucgggggc uucaacuuag acgcggaggc cccagcagua      300

cucucggggc ccccgggcuc cuucuucgga uucucagugg aguuuuaccg gccgggaaca      360

gacgggguca gugugcuggu gggagcaccc aaggcuaaua ccagccagcc aggagugcug      420

caggguggug cugucuaccu cuguccuugg ggugccagcc ccacacagug cacccccauu      480

gaauuugaca gcaaaggcuc ucggcuccug gaguccucac uguccagcuc agagggagag      540

gagccugugg aguacaaguc cuugcagugg uucggggcaa caguucgagc ccauggcucc      600

uccaucuugg caugcgcucc acuguacagc uggcgcacag agaaggagcc acugagcgac      660

cccgugggca ccugcuaccu cuccacagau aacuucaccc gaauucugga guaugcaccc      720

ugccgcucag auuucagcug ggcagcagga caggguuacu gccaaggagg cuucagugcc      780

gaguucacca agacuggccg ugugguuuua gguggaccag gaagcuauuu cuggcaaggc      840

cagauccugu cugccacuca ggagcagauu gcagaaucuu auuaccccga guaccugauc      900

aaccugguuc aggggcagcu gcagacucgc caggccaguu ccaucuauga ugacagcuac      960

cuaggauacu cuguggcugu uggugaauuc aguggugaug acacagaaga cuuuguugcu     1020

ggugugccca aagggaaccu cacuuacggc uaugucacca uccuuaaugg cucagacauu     1080

cgaucccucu acaacuucuc aggggaacag auggccuccu acuuuggcua ugcaguggcc     1140

gccacagacg ucaaugggga cgggcuggau gacuugcugg ugggggcacc ccugcucaug     1200

gaucggaccc cugacgggcg gccucaggag gugggcaggg ucuacgucua ccugcagcac     1260

ccagccggca uagagcccac gcccacccuu acccucacug gccaugauga guuuggccga     1320

uuuggcagcu ccuugacccc ccugggggac cuggaccagg auggcuacaa ugauguggcc     1380

aucggggcuc ccuuuggugg ggagacccag cagggaguag uguuuguauu uccugggggc     1440

ccaggagggc ugggcucuaa gccuucccag guucugcagc cccugugggc agccagccac     1500

accccagacu ucuuuggcuc ugcccuucga ggaggccgag accuggaugg caauggauau     1560

ccugaucuga uugugggguc cuuuggugug gacaaggcug ugguauacag gggccgcccc     1620

aucguguccg cuagugccuc ccucaccauc uuccccgcca uguucaaccc agaggagcgg     1680

agcugcagcu uagaggggaa cccuguggcc ugcaucaacc uuagcuucug ccucaaugcu     1740

ucuggaaaac acguugcuga cuccauuggu uucacagugg aacuucagcu ggacuggcag     1800

aagcagaagg gagggguacg gcgggcacug uuccuggccu ccaggcaggc aacccugacc     1860

cagacccugc ucauccagaa uggggcucga gaggauugca gagagaugaa gaucuaccuc     1920

aggaacgagu cagaauuucg agacaaacuc ucgccgauuc acaucgcucu caacuucucc     1980

uuggaccccc aagccccagu ggacagccac ggccucaggc cagcccuaca uuaucagagc     2040

aagagccgga uagaggacaa ggcucagauc uugcuggacu guggagaaga caacaucugu     2100

gugccugacc ugcagcugga aguguuuggg gagcagaacc auguguaccu gggugacaag     2160

aaugcccuga accucacuuu ccaugcccag aaugugggug aggguggcgc cuaugaggcu     2220

gagcuucggg ucaccgcccc uccagaggcu gaguacucag gacucgucag acacccaggg     2280

aacuucucca gccugagcug ugacuacuuu gccgugaacc agagccgccu gcuggugugu     2340

gaccugggca accccaugaa ggcaggagcc agucuguggg guggccuucg guuuacaguc     2400

ccucaucucc gggacacuaa gaaaaccauc caguuugacu uccagauccu cagcaagaau     2460

cucaacaacu cgcaaagcga cgugguuucc uuucggcucu ccguggaggc ucaggcccag     2520

gucacccuga acggugucuc caagccugag gcagugcuau ucccaguaag cgacuggcau     2580

ccccgagacc agccucagaa ggaggaggac cugggaccug cuguccacca ugucuaugag     2640

cucaucaacc aaggccccag cuccauuagc cagggugugc uggaacucag cuguccccag     2700

gcucuggaag gucagcagcu ccuauaugug accagaguua cgggacucaa cugcaccacc     2760

aaucacccca uuaacccaaa gggccuggag uuggaucccg aggguucccu gcaccaccag     2820

caaaaacggg aagcuccaag ccgcagcucu gcuuccucgg gaccucagau ccugaaaugc     2880

ccggaggcug aguguuucag gcugcgcugu gagcucgggc cccugcacca acaagagagc     2940

caaagucugc aguugcauuu ccgagucugg gccaagacuu ucuugcagcg ggagcaccag     3000

ccauuuagcc ugcaguguga ggcuguguac aaagcccuga agaugcccua ccgaauccug     3060

ccucggcagc ugccccaaaa agagcgucag guggccacag cugugcaaug gaccaaggca     3120

gaaggcagcu auggcguccc acuguggauc aucauccuag ccauccuguu uggccuccug     3180

cuccuagguc uacucaucua cauccucuac aagcuuggau ucuucaaacg cucccuccca     3240

uauggcaccg ccauggaaaa agcucagcuc aagccuccag ccaccucuga ugccuga        3297


<210>  1576
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAW96782

<400>  1576
augcccccgc gccagccccc ccggcaggcc ggcgggggcc ugagccgcga guucgggaag       60

cuccugcccg cccuguccca cagcccgcuc ggcgggcugg gcuccggcag cggguccgug      120

gcgcccggcc aggggcgggc cggcgccaug gggagccgca cccccgaguc cccccugcac      180

gccguccagc uccggugggg cccgcgccgg cgcccccccc ugcugccccu ccugcugcuc      240

cugcugccgc cccccccccg ggugggcggg uucaaccucg acgccgaggc gccggccgug      300

cugagcggcc cccccggguc cuucuucggc uucagcgucg aguucuaccg ccccggcacc      360

gacggggugu ccgugcuggu cggcgccccg aaggccaaca cgagccagcc cggggugcuc      420

cagggcgggg cgguguaccu gugccccugg ggcgccuccc ccacccagug caccccgauc      480

gaguucgaca gcaagggcuc ccggcugcuc gagagcuccc ugagcuccag cgagggggag      540

gagcccgucg aguacaagag ccugcagugg uucggcgcca ccgugcgcgc ccacgggucc      600

agcauccucg ccugcgcgcc ccuguacucc uggcggacgg agaaggagcc ccugagcgac      660

ccggugggca ccugcuaccu cuccaccgac aacuucaccc gcauccugga guacgccccc      720

ugccggagcg acuucuccug ggccgccggg cagggcuacu gccagggcgg guucagcgcc      780

gaguucacga agaccggccg cgucgugcug gggggccccg gguccuacuu cuggcagggc      840

cagauccuca gcgcgaccca ggagcagauc gccgaguccu acuacccgga guaccugauc      900

aaccuggugc agggccagcu ccagacccgg caggccagcu ccaucuacga cgacagcuac      960

cugggguacu ccgucgccgu gggcgaguuc agcggggacg acacggagga cuucguggcc     1020

ggcgucccca agggcaaccu gaccuacggg uacgugacca uccucaacgg cuccgacauc     1080

cgcagccugu acaacuucuc cggggagcag auggcgagcu acuucggcua cgccguggcc     1140

gccaccgacg ucaacgggga cggccuggac gaccuccugg ugggcgcccc ccugcucaug     1200

gaccggacgc ccgacgggcg cccgcaggag gugggccggg ucuacgugua ccugcagcac     1260

cccgcgggga ucgagcccac ccccacccug acccucacgg gccacgacga guucgggcgc     1320

uucggcagcu cccugacccc gcugggcgac cucgaccagg acggguacaa cgacgucgcc     1380

aucggcgccc ccuucggggg cgagacccag cagggggugg uguucgucuu ccccggcggc     1440

cccgggggcc uggggagcaa gccgucccag gugcugcagc cccugugggc cgcgagccac     1500

acccccgacu ucuucggcuc cgcccuccgc gggggccggg accuggacgg caacggguac     1560

cccgaccuga ucgugggcag cuucgggguc gacaaggccg ugguguaccg cggccggccg     1620

aucgucuccg ccagcgccuc ccucacgauc uuccccgcga uguucaaccc cgaggagcgc     1680

agcugcuccc uggagggcaa ccccguggcc ugcaucaacc ugagcuucug ccucaacgcc     1740

uccgggaagc acguggccga cagcaucggc uucaccgucg agcugcagcu ggacuggcag     1800

aagcagaagg ggggcgugcg gcgcgcccuc uuccuggcgu cccggcaggc cacccugacc     1860

cagacgcucc ugauccagaa cggggcccgc gaggacugcc gggagaugaa gaucuaccug     1920

cgcaacgaga gcgaguuccg ggacaagcuc uccccgaucc acaucgcccu gaacuucagc     1980

cuggaccccc aggcccccgu ggacagccac ggccuccgcc ccgcgcugca cuaccagucc     2040

aagagccgga ucgaggacaa ggcccagauc cugcucgacu gcggcgagga caacaucugc     2100

gucccggacc ugcagcugga gguguucggg gagcagaacc acguguaccu cggcgacaag     2160

aacgcccuga accugaccuu ccacgcccag aacgucgggg agggcggggc guacgaggcc     2220

gagcuccgcg ugaccgcccc ccccgaggcc gaguacuccg gccuggugcg gcacccgggc     2280

aacuucagcu cccugagcug cgacuacuuc gccgucaacc agucccgccu ccuggugugc     2340

gaccugggga accccaugaa ggcgggcgcc agccucuggg ggggccugcg guucaccgug     2400

ccccaccugc gcgacacgaa gaagaccauc caguucgacu uccagauccu cuccaagaac     2460

cugaacaaca gccaguccga cgucgugagc uuccggcugu ccguggaggc ccaggcccag     2520

gucacccuca acggggugag caagcccgag gccgugcugu ucccggucuc cgacuggcac     2580

ccccgcgacc agccccagaa ggaggaggac cugggccccg cggugcacca cguguacgag     2640

cucaucaacc agggcccgag cuccaucagc cagggggucc uggagcuguc cugcccccag     2700

gcccucgagg gccagcagcu gcuguacgug acccgcguga cggggcucaa cugcaccacc     2760

aaccacccca ucaaccccaa gggccuggag cuggacccgg agggcagccu ccaccaccag     2820

cagaagcggg aggcccccag ccgcuccagc gccuccagcg ggccccagau ccugaagugc     2880

cccgaggccg agugcuuccg gcugcgcugc gagcucggcc cgcugcacca gcaggagucc     2940

cagagccugc agcuccacuu ccgggucugg gcgaagaccu uccugcagcg cgagcaccag     3000

cccuucuccc ugcagugcga ggccguguac aaggcccuca agaugcccua ccggauccug     3060

ccccgccagc ugccgcagaa ggagcggcag guggccaccg cgguccagug gacgaaggcc     3120

gaggggagcu acggcgugcc ccucuggauc aucauccugg ccauccuguu cgggcuccug     3180

cugcucggcc ugcugaucua cauccucuac aagcugggcu ucuucaagcg cucccugccc     3240

uacgggaccg ccauggagaa ggcccagcuc aagcccccgg cgaccagcga cgccuga        3297


<210>  1577
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAW96782

<400>  1577
augccccccc gccagccccc ccgccaggcc ggcggcggcc ucucccgcga guucggcaag       60

cuccuccccg cccucuccca cuccccccuc ggcggccucg gcuccggcuc cggcuccguc      120

gcccccggcc agggccgcgc cggcgccaug ggcucccgca cccccgaguc cccccuccac      180

gccguccagc uccgcugggg cccccgccgc cgcccccccc uccucccccu ccuccuccuc      240

cuccuccccc cccccccccg cgucggcggc uucaaccucg acgccgaggc ccccgccguc      300

cucuccggcc cccccggcuc cuucuucggc uucuccgucg aguucuaccg ccccggcacc      360

gacggcgucu ccguccucgu cggcgccccc aaggccaaca ccucccagcc cggcguccuc      420

cagggcggcg ccgucuaccu cugccccugg ggcgccuccc ccacccagug cacccccauc      480

gaguucgacu ccaagggcuc ccgccuccuc gaguccuccc ucuccuccuc cgagggcgag      540

gagcccgucg aguacaaguc ccuccagugg uucggcgcca ccguccgcgc ccacggcucc      600

uccauccucg ccugcgcccc ccucuacucc uggcgcaccg agaaggagcc ccucuccgac      660

cccgucggca ccugcuaccu cuccaccgac aacuucaccc gcauccucga guacgccccc      720

ugccgcuccg acuucuccug ggccgccggc cagggcuacu gccagggcgg cuucuccgcc      780

gaguucacca agaccggccg cgucguccuc ggcggccccg gcuccuacuu cuggcagggc      840

cagauccucu ccgccaccca ggagcagauc gccgaguccu acuaccccga guaccucauc      900

aaccucgucc agggccagcu ccagacccgc caggccuccu ccaucuacga cgacuccuac      960

cucggcuacu ccgucgccgu cggcgaguuc uccggcgacg acaccgagga cuucgucgcc     1020

ggcgucccca agggcaaccu caccuacggc uacgucacca uccucaacgg cuccgacauc     1080

cgcucccucu acaacuucuc cggcgagcag auggccuccu acuucggcua cgccgucgcc     1140

gccaccgacg ucaacggcga cggccucgac gaccuccucg ucggcgcccc ccuccucaug     1200

gaccgcaccc ccgacggccg cccccaggag gucggccgcg ucuacgucua ccuccagcac     1260

cccgccggca ucgagcccac ccccacccuc acccucaccg gccacgacga guucggccgc     1320

uucggcuccu cccucacccc ccucggcgac cucgaccagg acggcuacaa cgacgucgcc     1380

aucggcgccc ccuucggcgg cgagacccag cagggcgucg ucuucgucuu ccccggcggc     1440

cccggcggcc ucggcuccaa gcccucccag guccuccagc cccucugggc cgccucccac     1500

acccccgacu ucuucggcuc cgcccuccgc ggcggccgcg accucgacgg caacggcuac     1560

cccgaccuca ucgucggcuc cuucggcguc gacaaggccg ucgucuaccg cggccgcccc     1620

aucgucuccg ccuccgccuc ccucaccauc uuccccgcca uguucaaccc cgaggagcgc     1680

uccugcuccc ucgagggcaa ccccgucgcc ugcaucaacc ucuccuucug ccucaacgcc     1740

uccggcaagc acgucgccga cuccaucggc uucaccgucg agcuccagcu cgacuggcag     1800

aagcagaagg gcggcguccg ccgcgcccuc uuccucgccu cccgccaggc cacccucacc     1860

cagacccucc ucauccagaa cggcgcccgc gaggacugcc gcgagaugaa gaucuaccuc     1920

cgcaacgagu ccgaguuccg cgacaagcuc ucccccaucc acaucgcccu caacuucucc     1980

cucgaccccc aggcccccgu cgacucccac ggccuccgcc ccgcccucca cuaccagucc     2040

aagucccgca ucgaggacaa ggcccagauc cuccucgacu gcggcgagga caacaucugc     2100

guccccgacc uccagcucga ggucuucggc gagcagaacc acgucuaccu cggcgacaag     2160

aacgcccuca accucaccuu ccacgcccag aacgucggcg agggcggcgc cuacgaggcc     2220

gagcuccgcg ucaccgcccc ccccgaggcc gaguacuccg gccucguccg ccaccccggc     2280

aacuucuccu cccucuccug cgacuacuuc gccgucaacc agucccgccu ccucgucugc     2340

gaccucggca accccaugaa ggccggcgcc ucccucuggg gcggccuccg cuucaccguc     2400

ccccaccucc gcgacaccaa gaagaccauc caguucgacu uccagauccu cuccaagaac     2460

cucaacaacu cccaguccga cgucgucucc uuccgccucu ccgucgaggc ccaggcccag     2520

gucacccuca acggcgucuc caagcccgag gccguccucu uccccgucuc cgacuggcac     2580

ccccgcgacc agccccagaa ggaggaggac cucggccccg ccguccacca cgucuacgag     2640

cucaucaacc agggccccuc cuccaucucc cagggcgucc ucgagcucuc cugcccccag     2700

gcccucgagg gccagcagcu ccucuacguc acccgcguca ccggccucaa cugcaccacc     2760

aaccacccca ucaaccccaa gggccucgag cucgaccccg agggcucccu ccaccaccag     2820

cagaagcgcg aggcccccuc ccgcuccucc gccuccuccg gcccccagau ccucaagugc     2880

cccgaggccg agugcuuccg ccuccgcugc gagcucggcc cccuccacca gcaggagucc     2940

cagucccucc agcuccacuu ccgcgucugg gccaagaccu uccuccagcg cgagcaccag     3000

cccuucuccc uccagugcga ggccgucuac aaggcccuca agaugcccua ccgcauccuc     3060

ccccgccagc ucccccagaa ggagcgccag gucgccaccg ccguccagug gaccaaggcc     3120

gagggcuccu acggcguccc ccucuggauc aucauccucg ccauccucuu cggccuccuc     3180

cuccucggcc uccucaucua cauccucuac aagcucggcu ucuucaagcg cucccucccc     3240

uacggcaccg ccauggagaa ggcccagcuc aagccccccg ccaccuccga cgccuga        3297


<210>  1578
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAW96782

<400>  1578
augcccccua gacagccacc gaggcaagcc ggcgggggac ugagccggga guucgguaag       60

cuccuucccg cucuguccca cucuccuuug ggcggguuag gaucaggcag ugguagcgug      120

gcaccagggc agggacgcgc cggcgcgaug ggcucccgaa cccccgaauc uccucugcau      180

gcuguccagc uacguugggg gccaagaagg cggcccccuc uccugccacu ucuguugcuc      240

cugcugccgc ccccuccacg cguuggaggu uuuaaccucg acgccgaggc acccgccgug      300

uuaucgggcc cuccaggguc auucuuugga uucagcguag aauuuuacag acccggcaca      360

gaugguguga guguccuggu gggggcuccg aaagcaaaua cuucccagcc uggaguucuu      420

caaggcggcg ccguguauuu gugccccugg ggagcuucuc caacgcagug uaccccuauc      480

gaguucgaca gcaagggguc caggcugcua gaaucaaguc ucucuagcuc cgagggugag      540

gaacccgucg aguacaaauc acugcagugg uuuggcgcca cagugcgggc gcacgggagc      600

aguauucuug caugcgcccc acuguauucu uggcgcacug aaaaggagcc cuuguccgau      660

ccuguaggaa ccuguuaccu cagcacagac aacuucaccc gaauacugga guaugcucca      720

ugcagaucgg auuuuucuug ggccgcaggc caggguuacu gucaaggggg cuucuccgcu      780

gaauuuacua aaacaggaag gguuguguua ggcgggccgg gaucauauuu cuggcagggu      840

cagauccuga gugccaccca ggagcaaauu gcggaaagcu acuaccccga guaucucauc      900

aaucuugucc agggccagcu gcaaacgcgg caggccuccu cuauuuacga cgauagcuau      960

uugggguacu caguggcagu gggagaauuu aguggcgacg auacugagga cuucgucgcu     1020

gguguuccua aggggaaccu aaccuauggc uacgugacaa uccugaaugg auccgauaua     1080

cguagccucu auaacuucuc uggcgagcag auggccucau acuuugggua cgcuguagcc     1140

gcaacugacg ugaauggaga uggucuggac gaccuucugg ucggcgcccc auugcucaug     1200

gaucgcaccc ccgacgggag accucaggaa gugggaaggg uuuaugugua ccugcaacau     1260

ccagcuggca ucgagcccac accgaccuua acgcugacug gucacgauga guucgggcgg     1320

uuuggcagua gccuaacacc ucucggagac cuggaucagg acggcuauaa cgaugucgcg     1380

auuggggcac cauucggagg cgagacccag cagggugugg uauuuguuuu ccccggggga     1440

ccuggcgguc uuggcuccaa gcccucucaa guguugcagc cacugugggc cgcuucgcau     1500

acuccugacu uuuucgggag cgcccuccga ggaggccgcg aucuggacgg gaauggauac     1560

cccgaucuua ucgucggcuc cuuuggugug gacaaagcag ucguguauag agggaggcca     1620

auuguuucag ccagugcuuc ucugacaauc uucccggcca uguuuaaccc ugaagaacgg     1680

agcugcuccu uggagggaaa ucccguggca uguauaaacc ucucauucug ccugaaugcg     1740

agcggcaagc acguagcuga cucuauuggu uuuaccgucg aauuacagcu ggauuggcag     1800

aaacaaaagg gcggggugcg cagagcccua uuccucgcau ccaggcaggc cacgcugacc     1860

cagacacuuu ugauccagaa cggagcucgu gaggacuguc gggaaaugaa aauuuaccug     1920

cgaaaugaga gugaguucag agauaagcuc agcccaaucc acaucgcccu gaacuuuucu     1980

uuagaccccc aagcaccugu ugauucccau ggccugaggc cagcccuuca cuaucaguca     2040

aagagucgca uugaagacaa agcucagaua uugcucgauu gcggggagga caacaucugu     2100

gugcccgauc ugcaacuaga agucuucgga gagcagaauc auguguaccu gggcgacaag     2160

aacgcgcuca aucugacuuu ucacgcccag aacguaggug aagggggagc uuacgaggca     2220

gagcuucggg ugaccgcccc uccggaagcu gaguauagcg gcuugguuag acacccaggu     2280

aauuucucgu cccugucuug cgauuacuuu gccgucaacc agagcagguu acucgugugc     2340

gaccugggca aucccaugaa agcaggggcg ucacuuuggg gaggccugcg cuucacagug     2400

ccucauuugc gagauacuaa gaaaaccauu caauuugacu uccagauccu caguaagaac     2460

cugaauaacu cccagucuga cgucguuagc uuucggcuau ccguggaagc ccaggcucaa     2520

gugacacuga augggguauc aaaaccagag gccguccucu uccccgugag cgauuggcac     2580

ccucgugacc agccgcagaa ggaagaggau cugggacccg caguucauca cguguaugag     2640

cuuauaaacc agggcccaag uucuauuucc caaggugucu uggaacugag cuguccucag     2700

gcuuuagagg ggcagcaacu ccuguacgug accagaguua cuggacuuaa uugcacgaca     2760

aaccauccca ucaauccaaa gggccuggaa cuagacccug agggcucgcu ccaccaccag     2820

cagaaaaggg aagcccccuc acgcucuagu gcauccagcg ggccacagau ccugaagugu     2880

ccggaggccg agugcuuucg guugagaugu gaacugggac cuuuacauca acaggagucu     2940

cagagccucc agcugcacuu cagggugugg gcuaaaaccu uucuucaacg agaacaucag     3000

cccuucuccc ugcagugcga ggcgguauau aaggccuuga aaaugccaua ccgcauucuc     3060

ccccggcagc ugccucaaaa ggaaagacag gucgcaacug cugugcagug gaccaaggcc     3120

gaggguucau auggcgugcc acuauggauc auuauacugg ccauccuuuu cgggcuccug     3180

uugcugggau uacucauuua cauccuguac aaacuuggcu uuuucaagag gagucugccc     3240

uaugguacag cuauggagaa agcacaguug aagccuccgg ccaccagcga ugcguga        3297


<210>  1579
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAW96782

<400>  1579
augcccccca gacagccccc cagacaggcc ggcggcggcc ugagcagaga guucggcaag       60

cugcugcccg cccugagcca cagcccccug ggcggccugg gcagcggcag cggcagcgug      120

gcccccggcc agggcagagc cggcgccaug ggcagcagaa cccccgagag cccccugcac      180

gccgugcagc ugagaugggg ccccagaaga agaccccccc ugcugccccu gcugcugcug      240

cugcugcccc ccccccccag agugggcggc uucaaccugg acgccgaggc ccccgccgug      300

cugagcggcc cccccggcag cuucuucggc uucagcgugg aguucuacag acccggcacc      360

gacggcguga gcgugcuggu gggcgccccc aaggccaaca ccagccagcc cggcgugcug      420

cagggcggcg ccguguaccu gugccccugg ggcgccagcc ccacccagug cacccccauc      480

gaguucgaca gcaagggcag cagacugcug gagagcagcc ugagcagcag cgagggcgag      540

gagcccgugg aguacaagag ccugcagugg uucggcgcca ccgugagagc ccacggcagc      600

agcauccugg ccugcgcccc ccuguacagc uggagaaccg agaaggagcc ccugagcgac      660

cccgugggca ccugcuaccu gagcaccgac aacuucacca gaauccugga guacgccccc      720

ugcagaagcg acuucagcug ggccgccggc cagggcuacu gccagggcgg cuucagcgcc      780

gaguucacca agaccggcag aguggugcug ggcggccccg gcagcuacuu cuggcagggc      840

cagauccuga gcgccaccca ggagcagauc gccgagagcu acuaccccga guaccugauc      900

aaccuggugc agggccagcu gcagaccaga caggccagca gcaucuacga cgacagcuac      960

cugggcuaca gcguggccgu gggcgaguuc agcggcgacg acaccgagga cuucguggcc     1020

ggcgugccca agggcaaccu gaccuacggc uacgugacca uccugaacgg cagcgacauc     1080

agaagccugu acaacuucag cggcgagcag auggccagcu acuucggcua cgccguggcc     1140

gccaccgacg ugaacggcga cggccuggac gaccugcugg ugggcgcccc ccugcugaug     1200

gacagaaccc ccgacggcag accccaggag gugggcagag uguacgugua ccugcagcac     1260

cccgccggca ucgagcccac ccccacccug acccugaccg gccacgacga guucggcaga     1320

uucggcagca gccugacccc ccugggcgac cuggaccagg acggcuacaa cgacguggcc     1380

aucggcgccc ccuucggcgg cgagacccag cagggcgugg uguucguguu ccccggcggc     1440

cccggcggcc ugggcagcaa gcccagccag gugcugcagc cccugugggc cgccagccac     1500

acccccgacu ucuucggcag cgcccugaga ggcggcagag accuggacgg caacggcuac     1560

cccgaccuga ucgugggcag cuucggcgug gacaaggccg ugguguacag aggcagaccc     1620

aucgugagcg ccagcgccag ccugaccauc uuccccgcca uguucaaccc cgaggagaga     1680

agcugcagcc uggagggcaa ccccguggcc ugcaucaacc ugagcuucug ccugaacgcc     1740

agcggcaagc acguggccga cagcaucggc uucaccgugg agcugcagcu ggacuggcag     1800

aagcagaagg gcggcgugag aagagcccug uuccuggcca gcagacaggc cacccugacc     1860

cagacccugc ugauccagaa cggcgccaga gaggacugca gagagaugaa gaucuaccug     1920

agaaacgaga gcgaguucag agacaagcug agccccaucc acaucgcccu gaacuucagc     1980

cuggaccccc aggcccccgu ggacagccac ggccugagac ccgcccugca cuaccagagc     2040

aagagcagaa ucgaggacaa ggcccagauc cugcuggacu gcggcgagga caacaucugc     2100

gugcccgacc ugcagcugga gguguucggc gagcagaacc acguguaccu gggcgacaag     2160

aacgcccuga accugaccuu ccacgcccag aacgugggcg agggcggcgc cuacgaggcc     2220

gagcugagag ugaccgcccc ccccgaggcc gaguacagcg gccuggugag acaccccggc     2280

aacuucagca gccugagcug cgacuacuuc gccgugaacc agagcagacu gcuggugugc     2340

gaccugggca accccaugaa ggccggcgcc agccuguggg gcggccugag auucaccgug     2400

ccccaccuga gagacaccaa gaagaccauc caguucgacu uccagauccu gagcaagaac     2460

cugaacaaca gccagagcga cguggugagc uucagacuga gcguggaggc ccaggcccag     2520

gugacccuga acggcgugag caagcccgag gccgugcugu uccccgugag cgacuggcac     2580

cccagagacc agccccagaa ggaggaggac cugggccccg ccgugcacca cguguacgag     2640

cugaucaacc agggccccag cagcaucagc cagggcgugc uggagcugag cugcccccag     2700

gcccuggagg gccagcagcu gcuguacgug accagaguga ccggccugaa cugcaccacc     2760

aaccacccca ucaaccccaa gggccuggag cuggaccccg agggcagccu gcaccaccag     2820

cagaagagag aggcccccag cagaagcagc gccagcagcg gcccccagau ccugaagugc     2880

cccgaggccg agugcuucag acugagaugc gagcugggcc cccugcacca gcaggagagc     2940

cagagccugc agcugcacuu cagagugugg gccaagaccu uccugcagag agagcaccag     3000

cccuucagcc ugcagugcga ggccguguac aaggcccuga agaugcccua cagaauccug     3060

cccagacagc ugccccagaa ggagagacag guggccaccg ccgugcagug gaccaaggcc     3120

gagggcagcu acggcgugcc ccuguggauc aucauccugg ccauccuguu cggccugcug     3180

cugcugggcc ugcugaucua cauccuguac aagcugggcu ucuucaagag aagccugccc     3240

uacggcaccg ccauggagaa ggcccagcug aagccccccg ccaccagcga cgccuga        3297


<210>  1580
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAW96782

<400>  1580
augcccccua gacagccgcc ccggcaagcc ggcgggggac ugagccgcga guucggcaag       60

cuccugccug cucuuuccca cucuccccuc gggggacucg gcagcggguc cggaucugug      120

gccccuggcc agggcagagc gggggcuaug ggaagccgga cccccgaauc cccucugcau      180

gccguccagc uucgcugggg cccgagacgg agacccccuc ugcucccccu gcugcuccug      240

cuucugccuc ccccgccucg cguuggggga uuuaaccucg acgccgaggc ucccgccgug      300

cugucuggcc cucccgggag cuucuuugga uucuccgugg aauuuuaccg gcccggcaca      360

gauggcguca gcgugcuugu uggggcuccu aaagccaaua cgucucagcc gggagugcug      420

caaggcgggg cggucuaucu cugccccugg ggagccuccc cuacccagug uacacccauc      480

gaguucgaca gcaagggcuc ucgccugcug gaauccagcc ucucuuccag cgagggggag      540

gaaccugugg aguacaaauc ccugcagugg uuuggagcua ccguuagagc ccacggcucu      600

agcauucuug cuugcgcgcc ccuguauucc uggcggacag aaaaggagcc gcucagcgau      660

ccugugggca ccuguuaccu gucuacagac aacuucaccc gcauccuuga guaugccccc      720

ugcagauccg auuuuagcug ggccgcuggg cagggauacu gucaaggcgg guucucugcc      780

gaauuuacga aaaccggacg ggucgugcug ggcgggccug gcagcuauuu cuggcaggga      840

cagauucucu ccgcuacaca ggagcaaauc gccgaaucuu acuaccccga guaucugauu      900

aaucuggugc agggccagcu ccaaacccgc caggccagcu ccaucuacga cgauagcuau      960

cugggguacu cugucgcugu uggagaauuu uccggcgacg auacagagga cuucguggcg     1020

ggggugccua agggaaaccu uaccuauggc uacgucacga uccugaaugg gagcgauauu     1080

agaucucucu auaacuucuc cggcgagcag auggccagcu acuuuggaua cgcuguggcc     1140

gccacagacg uuaauggcga ugggcuggac gaccuucugg ugggagcucc ccuccugaug     1200

gaucggaccc cggacggcag accucaggaa gucgggcgcg uguauguuua ccugcaacau     1260

cccgccggaa ucgagcccac accuacccuc acccugacag gccacgauga guucgggcgg     1320

uuuggcuccu cucuuacgcc gcugggagac cucgaucagg acggcuauaa cgauguggcg     1380

auuggggcuc ccuucggagg cgaaacccag cagggggucg uguuugucuu cccuggaggc     1440

cccgggggcc ugggaagcaa gccuucccaa gugcugcagc cccuuugggc cgccucucau     1500

acaccugacu uuuucggcag cgcucucaga gggggacgcg aucuggacgg caauggguac     1560

cccgaucuga ucguuggauc cuuuggcgug gacaaagccg ucguguaucg gggcagaccg     1620

auuguuagcg cuucugccuc ccucaccauc uucccugcga uguuuaaccc cgaggaacgc     1680

agcugcucuc uggaggggaa uccuguggcc uguauuaacc uuuccuucug ccugaaugcu     1740

agcggaaagc acgucgccga cucuaucggc uuuacagugg aacuccagcu ggauuggcag     1800

aaacaaaaag ggggagugcg gagagcucug uuccuugcca gccgccaggc gacccucacg     1860

cagacacugc ugauccagaa cggcgcccgg gaggacugua gagaaaugaa gauuuaccuc     1920

cgcaaugagu ccgaguuccg ggauaagcug agccccaucc acauugcucu uaacuuuucu     1980

cuggacccgc aagccccugu ugauucccau gggcucagac ccgcucugca cuaucagagc     2040

aagucccgga ucgaagacaa agcccagauu cugcuugauu gcggagagga caacaucugu     2100

gucccugauc uccaacugga aguguucggc gagcagaauc auguguaccu gggcgacaag     2160

aacgcccuca aucugaccuu ucacgcucag aacgucgggg aaggaggcgc guacgaggcc     2220

gagcuucgcg ugaccgcucc ucccgaagcc gaguauucug ggcugguuag acaccccgga     2280

aauuucagcu cccucucuug cgauuacuuu gccgugaacc agagccggcu gcuggucugc     2340

gaccuuggca auccgaugaa agcuggggcc ucccucuggg gaggccugag auucacagug     2400

ccccaucugc gcgauaccaa gaaaacaauc caauuugacu uccagauucu cucuaagaac     2460

cugaauaaca gccaguccga cguugugagc uuucggcuuu cugucgaagc gcaggcucaa     2520

gugacgcuga auggcguuuc caaaccugag gccgugcugu uccccgucag cgauuggcac     2580

ccuagagacc agccccagaa ggaagaggau cuggggccug ccgugcauca cguguaugag     2640

cugaucaacc agggaccguc uuccauuagc caaggcgucc uugaacuguc uuguccccag     2700

gcucucgagg ggcagcaacu gcucuacguu acccgcguga caggacugaa uugcaccaca     2760

aaccauccua ucaaucccaa gggccuugaa cuggacccug aggggucccu ccaccaccag     2820

cagaaaagag aagcccccag ccgguccagc gcgucuagcg gaccgcagau ucugaagugu     2880

ccugaggcug agugcuuucg ccugagaugu gaacuuggcc cccugcauca acaggagucc     2940

cagucucucc agcugcacuu ccgggugugg gccaaaaccu uucuccaacg cgaacaucag     3000

cccuucagcc ugcagugcga ggccgucuau aaggcucuua aaaugccuua cagaauccug     3060

ccccggcagc ucccucaaaa ggaacgccag guggccacgg cuguucagug gaccaaggcc     3120

gagggcuccu auggggugcc gcuguggauc auuauccugg cgauucuuuu cggacugcuc     3180

cugcucggcc ugcuuaucua cauucuguac aaacuggggu uuuucaagag aucucucccc     3240

uauggaacag ccauggagaa agcucagcug aagccucccg ccaccagcga ugcuuga        3297


<210>  1581
<211>  1198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A0A024RDT9

<400>  1581

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser 
1               5                   10                  15      


Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln 
            20                  25                  30          


Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg 
        35                  40                  45              


Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro 
    50                  55                  60                  


Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly 
65                  70                  75                  80  


Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val 
                85                  90                  95      


Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His 
            100                 105                 110         


Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met 
        115                 120                 125             


Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly 
    130                 135                 140                 


Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr 
145                 150                 155                 160 


Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp 
                165                 170                 175     


Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp 
            180                 185                 190         


Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro 
        195                 200                 205             


Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly 
    210                 215                 220                 


Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser Gly 
225                 230                 235                 240 


Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys Asp 
                245                 250                 255     


Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys Pro 
            260                 265                 270         


Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser Pro 
        275                 280                 285             


Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro Glu 
    290                 295                 300                 


Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly Lys 
305                 310                 315                 320 


Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn Asp 
                325                 330                 335     


Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr Asn 
            340                 345                 350         


Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu Ser 
        355                 360                 365             


Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr Lys 
    370                 375                 380                 


Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser Lys 
385                 390                 395                 400 


Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly Glu 
                405                 410                 415     


Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr Lys 
            420                 425                 430         


Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn Asp 
        435                 440                 445             


Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser Gly 
    450                 455                 460                 


Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly Ile 
465                 470                 475                 480 


Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser Asp 
                485                 490                 495     


Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly Tyr 
            500                 505                 510         


Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val Lys 
        515                 520                 525             


Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr Asn 
    530                 535                 540                 


Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr Cys 
545                 550                 555                 560 


Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys Ile 
                565                 570                 575     


His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn Gly 
            580                 585                 590         


Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser Asn 
        595                 600                 605             


Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His Leu 
    610                 615                 620                 


Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr Cys 
625                 630                 635                 640 


Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val Gln 
                645                 650                 655     


Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln Gly 
            660                 665                 670         


Arg Pro Lys Ala Lys Glu Ile Gln Leu Arg Trp Gly Pro Pro Leu Val 
        675                 680                 685             


Asp Gly Gly Ser Pro Ile Ser Cys Tyr Ser Val Glu Met Ser Pro Ile 
    690                 695                 700                 


Glu Lys Asp Glu Pro Arg Glu Val Tyr Gln Gly Ser Glu Val Glu Cys 
705                 710                 715                 720 


Thr Val Ser Ser Leu Leu Pro Gly Lys Thr Tyr Ser Phe Arg Leu Arg 
                725                 730                 735     


Ala Ala Asn Lys Met Gly Phe Gly Pro Phe Ser Glu Lys Cys Asp Ile 
            740                 745                 750         


Thr Thr Ala Pro Gly Pro Pro Asp Gln Cys Lys Pro Pro Gln Val Thr 
        755                 760                 765             


Cys Arg Ser Ala Thr Cys Ala Gln Val Asn Trp Glu Val Pro Leu Ser 
    770                 775                 780                 


Asn Gly Thr Asp Val Thr Glu Tyr Arg Leu Glu Trp Gly Gly Val Glu 
785                 790                 795                 800 


Gly Ser Met Gln Ile Cys Tyr Cys Gly Pro Gly Leu Ser Tyr Glu Ile 
                805                 810                 815     


Lys Gly Leu Ser Pro Ala Thr Thr Tyr Tyr Cys Arg Val Gln Ala Leu 
            820                 825                 830         


Ser Val Val Gly Ala Gly Pro Phe Ser Glu Val Val Ala Cys Val Thr 
        835                 840                 845             


Pro Pro Ser Val Pro Gly Ile Val Thr Cys Leu Gln Glu Ile Ser Asp 
    850                 855                 860                 


Asp Glu Ile Glu Asn Pro His Tyr Ser Pro Ser Thr Cys Leu Ala Ile 
865                 870                 875                 880 


Ser Trp Glu Lys Pro Cys Asp His Gly Ser Glu Ile Leu Ala Tyr Ser 
                885                 890                 895     


Ile Asp Phe Gly Asp Lys Gln Ser Leu Thr Val Gly Lys Val Thr Ser 
            900                 905                 910         


Tyr Ile Ile Asn Asn Leu Gln Pro Asp Thr Thr Tyr Arg Ile Arg Ile 
        915                 920                 925             


Gln Ala Leu Asn Ser Leu Gly Ala Gly Pro Phe Ser His Met Ile Lys 
    930                 935                 940                 


Leu Lys Thr Lys Pro Leu Pro Pro Asp Pro Pro Arg Leu Glu Cys Val 
945                 950                 955                 960 


Ala Phe Ser His Gln Asn Leu Lys Leu Lys Trp Gly Glu Gly Thr Pro 
                965                 970                 975     


Lys Thr Leu Ser Thr Asp Ser Ile Gln Tyr His Leu Gln Met Glu Asp 
            980                 985                 990         


Lys Asn Gly Arg Phe Val Ser Leu Tyr Arg Gly Pro Cys His Thr Tyr 
        995                 1000                1005            


Lys Val Gln Arg Leu Asn Glu Ser Thr Ser Tyr Lys Phe Cys Ile Gln 
    1010                1015                1020                


Ala Cys Asn Glu Ala Gly Glu Gly Pro Leu Ser Gln Glu Tyr Ile Phe 
1025                1030                1035                1040


Thr Thr Pro Lys Ser Val Pro Ala Ala Leu Lys Ala Pro Lys Ile Glu 
                1045                1050                1055    


Lys Val Asn Asp His Ile Cys Glu Ile Thr Trp Glu Cys Leu Gln Pro 
            1060                1065                1070        


Met Lys Gly Asp Pro Val Ile Tyr Ser Leu Gln Val Met Leu Gly Lys 
        1075                1080                1085            


Asp Ser Glu Phe Lys Gln Ile Tyr Lys Gly Pro Asp Ser Ser Phe Arg 
    1090                1095                1100                


Tyr Ser Ser Leu Gln Leu Asn Cys Glu Tyr Arg Phe Arg Val Cys Ala 
1105                1110                1115                1120


Ile Arg Gln Cys Gln Asp Ser Leu Gly His Gln Asp Leu Val Gly Pro 
                1125                1130                1135    


Tyr Ser Thr Thr Val Leu Phe Ile Ser Gln Arg Thr Glu Pro Pro Ala 
            1140                1145                1150        


Ser Thr Asn Arg Asp Thr Val Glu Ser Thr Arg Thr Arg Arg Ala Leu 
        1155                1160                1165            


Ser Asp Glu Gln Cys Ala Ala Val Ile Leu Val Leu Phe Ala Phe Phe 
    1170                1175                1180                


Ser Ile Leu Ile Ala Phe Ile Ile Gln Tyr Phe Val Ile Lys 
1185                1190                1195            


<210>  1582
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAX08808

<400>  1582
auggcagaac auccaccacu acuggauaca acucagaucu uaaguaguga uauuucucuu       60

uugucugccc cuauuguaag ugcagaugga acacaacagg uuauucuggu acaaguuaac      120

ccaggagaag cauuuacaau aagaagagaa gauggacagu uucagugcau uacagguccu      180

gcucagguuc caaugauguc cccaaauggu ucugugccuc cuaucuaugu gccuccugga      240

uaugccccac agguuauuga agacaauggu guucgaagag uugucguggu cccucaggca      300

ccagaguuuc acccugguag ucacacaguu cuccaccguu cuccacaucc uccucuaccu      360

gguuucauuc cugucccaac uaugaugccg ccuccaccac gucauaugua cucacccgug      420

acuggagcug gagacaugac aacacaguau augccacagu aucagucuuc acaagucuau      480

ggagauguag augcucacuc uacacaugga agguccaacu uuagagauga acgaucuagu      540

aaaacauaug aacguuugca gaaaaaauug aaggaucgcc aaggaacaca gaaagauaaa      600

augagcaguc caccaucauc accccagaaa ugcccuucuc ccauuaauga acauaaugga      660

cuuauaaaag gacaaauugc uggugguaua aacacaggau cagcaaaaau caagucuggg      720

aaggggaaag gugguacaca aguugauaca gaaauugaag aaaaagauga agaaacuaaa      780

gcauuugaag cacuucuuuc caacauuguc aaaccagugg ccuccgacau ccaggcaagg      840

acaguaguac uuaccugguc accaccuucc agccucauua auggugaaac agaugaaagu      900

aguguaccag agcucuaugg uuaugaaguu cugaucucaa guacuggaaa agaugggaaa      960

uacaaaagug uauauguagg agaagaaaca aauaucacuu uaaaugaucu caagccagcc     1020

auggauuacc augcaaaagu ccaggcagaa uauaauucua uaaagggaac uccuucagag     1080

gcugaaaucu uuaccaccuu gagcugugaa ccugauauac cuaauccacc aaggauagcc     1140

aaucggacca aaaauucacu cacuuugcaa uggaaggcac cuagugacaa ugguucuaaa     1200

auccaaaacu uuguauuaga augggaugaa ggaaaaggaa auggagaauu uugucagugu     1260

uacaugggcu cacagaaaca auuuaaaauu acuaaacuuu caccagcaau gggcuguaaa     1320

uucagacuau cggccagaaa ugacuauggu acaagugguu uuagugaaga agucuuauau     1380

uacaccucag gcugugcucc uucuaugcca gcaaguccug uauuaaccaa ggcuggaauu     1440

acuugguuau ccuuacaaug gaguaagccc ucaggaacac caucagauga aggaauuucu     1500

uacauuuuag agauggagga agaaacuuca ggauaugguu uuaagccuaa auaugaugga     1560

gaagaucuug cuuacacagu gaaaaaucuc agacguagua cuaaguauaa auuuaagguu     1620

auugcuuaca acucagaagg uaaaaguaau ccaagugaag uaguagaauu uacuacuugc     1680

ccugauaaac caggcauacc uguaaagccu ucagugaaag gaaagauaca uucacacagu     1740

uuuaaaauaa ccugggaucc accaaaagac aauggcggag caaccaucaa uaaauaugua     1800

guggagaugg cagaagguuc uaacggaaac aaaugggaaa ugauauacag uggugcuacc     1860

agggaacauc uuugugaucg acugaaucca ggcuguuucu aucguuuacg aguuuacugc     1920

aucagugaug gaggacagag ugcggucucu gaaucuuuac uugugcagac uccagcugug     1980

ccuccuggcc caugccuccc ucccagauua caggguagac ccaaagcaaa agaaauacag     2040

uuacgauggg gacccccucu gguugauggu ggaucaccca uuuccuguua caguguggaa     2100

augucuccua uagaaaaaga ugaaccuaga gaaguuuacc aagguucuga aguagaaugu     2160

acagugagca gccuucuucc uggaaagaca uacagcuuca gacuacgugc agcuaacaaa     2220

augggguuug gaccauuuuc agaaaaaugu gauauuacua cagccccugg gccaccagau     2280

cagugcaagc ccccucaagu gacauguaga ucugcaacuu gugcacaagu gaauugggag     2340

guuccuuuga guaauggaac agaugucacu gaauaucgac uggagugggg aggaguugaa     2400

ggaaguaugc agauauguua cugugggccu ggucucaguu augaaauaaa aggacuuuca     2460

ccagcaacua ccuauuauug caggguccag gcucugagug uugugggugc aggcccuuuc     2520

agugaaguag uagccugugu gacuccacca ucaguuccug gcauugugac cugucuucaa     2580

gaaauaagcg augaugagau agaaaauccc cauuauucac cuucuacaug ccuugcaaua     2640

agcugggaaa agccuuguga ucaugguucg gaaauccuug ccuacagcau agacuuugga     2700

gauaaacaau cccuaacagu gggaaagguu acaagcuaua uuaucaacaa uuugcaacca     2760

gauacaacau acagaauacg aauucaagcc uugaauagcc uuggagcugg uccuuucagc     2820

cauaugauaa aauuaaaaac uaagccucuc ccuccugauc caccucgucu ggaauguguu     2880

gccuuuagcc accagaaccu uaagcugaaa uggggagaag gaacuccaaa gacauuguca     2940

accgauucua uucaguacca ccuucagaug gaggauaaga auggacgguu uguaucccua     3000

uacagaggac caugucauac auacaaagua caaagacuua augagucaac auccuauaaa     3060

uucuguauuc aagcuuguaa ugaagcuggg gaaggucccc ucucccaaga auauauuuuc     3120

acuacuccaa aaucuguccc agcugccuug aaagccccca aaauagagaa aguaaaugau     3180

cacauuugug aaauuacaug ggaguguuua cagccaauga aaggugaucc aguuauuuac     3240

agucuucaag uuauguuggg aaaagauuca gaauucaaac agauuuacaa gggucccgac     3300

ucuuccuucc gguauuccag ccuucagcug aacugugaau aucgcuuccg uguaugugcc     3360

auucgccagu gccaagacuc ucugggacac caggaccucg uaggucccua cagcaccaca     3420

gugcucuuca ucucucagag gacugaacca ccagccagca ccaacagaga cacuguggaa     3480

agcacaagga cccgacgggc acugagugac gagcagugug cugccgucau ccuugugcug     3540

uuugcuuucu uuuccauuuu gauugccuuu aucauucagu acuuuguaau caaguga        3597


<210>  1583
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAX08808

<400>  1583
auggccgagc acccgccccu gcucgacacc acccagaucc ugagcuccga caucagccug       60

cucuccgccc ccaucgugag cgcggacggc acgcagcagg ucauccuggu ccaggugaac      120

cccggggagg ccuucaccau ccgccgggag gacggccagu uccagugcau caccgggccc      180

gcccaggucc ccaugauguc ccccaacggc agcgugccgc ccaucuacgu gccgcccggg      240

uacgcgcccc aggucaucga ggacaacggc gugcgccggg uggucguggu gccccaggcc      300

cccgaguucc accccggcuc ccacaccguc cugcaccgca gcccccaccc gccccucccc      360

ggguucaucc ccgugcccac gaugaugccg cccccgcccc ggcacaugua cucccccgug      420

accggcgccg gggacaugac cacccaguac augccccagu accagagcuc ccaggucuac      480

ggcgacgugg acgcccacag cacgcacggg cgcuccaacu uccgggacga gcgcagcucc      540

aagaccuacg agcggcugca gaagaagcug aaggaccgcc agggcaccca gaaggacaag      600

augagcuccc cgcccagcag cccccagaag ugccccuccc ccaucaacga gcacaacggc      660

cucaucaagg ggcagaucgc cggcgggauc aacaccggca gcgccaagau caaguccggc      720

aaggggaagg gcgggaccca gguggacacg gagaucgagg agaaggacga ggagaccaag      780

gcguucgagg cccugcugag caacaucguc aagccggugg ccuccgacau ccaggcccgg      840

accguggucc ucacguggag cccgcccucc agccugauca acggcgagac cgacgagucc      900

agcgugcccg agcuguacgg guacgaggug cucaucucca gcaccggcaa ggacggcaag      960

uacaaguccg ucuacguggg ggaggagacc aacaucacgc ugaacgaccu gaagcccgcc     1020

auggacuacc acgcgaaggu ccaggccgag uacaacagca ucaagggcac ccccuccgag     1080

gccgagaucu ucaccacccu cagcugcgag cccgacaucc ccaacccgcc ccgcaucgcc     1140

aaccggacga agaacucccu gacccugcag uggaaggccc ccagcgacaa cggguccaag     1200

auccagaacu ucgugcucga gugggacgag ggcaagggga acggcgaguu cugccagugc     1260

uacaugggca gccagaagca guucaagauc accaagcugu cccccgcgau ggggugcaag     1320

uuccgccuga gcgcccggaa cgacuacggc accagcgggu ucuccgagga ggugcucuac     1380

uacacgagcg gcugcgcccc guccaugccc gccagccccg uccugaccaa ggccgggauc     1440

accuggcugu cccuccagug gagcaagccc uccggcaccc cgagcgacga gggcaucucc     1500

uacauccugg agauggagga ggagacgagc ggguacggcu ucaagcccaa guacgacggg     1560

gaggaccugg cguacaccgu gaagaaccuc cgccggucca ccaaguacaa guucaaggug     1620

aucgccuaca acagcgaggg caaguccaac cccagcgagg ucguggaguu caccacgugc     1680

cccgacaagc cgggcauccc cgugaagccc uccgucaagg ggaagaucca cagccacucc     1740

uucaagauca ccugggaccc gcccaaggac aacggcgggg ccaccaucaa caaguacgug     1800

guggagaugg ccgagggcag caacgggaac aagugggaga ugaucuacag cggcgccacc     1860

cgcgagcacc ugugcgaccg gcugaacccc ggcugcuucu accgccuccg ggucuacugc     1920

aucuccgacg ggggccagag cgcggugucc gagagccugc uggugcagac ccccgccguc     1980

ccgcccgggc ccugccugcc cccgcgccuc cagggccgcc ccaaggccaa ggagauccag     2040

cugcgguggg ggccgccccu cguggacggc ggcuccccca ucagcugcua cuccguggag     2100

augagcccca ucgagaagga cgagccccgc gaggucuacc agggguccga gguggagugc     2160

acggugagcu cccugcugcc cggcaagacc uacagcuucc ggcuccgcgc cgcgaacaag     2220

augggguucg gcccguucuc cgagaagugc gacaucacca ccgcccccgg gccgcccgac     2280

cagugcaagc cgccccaggu cacgugccgg agcgcgaccu gcgcccaggu gaacugggag     2340

gugccccugu ccaacggcac cgacgucacc gaguaccgcc uggagugggg cgggguggag     2400

ggcagcaugc agaucugcua cugcgggccc ggccucuccu acgagaucaa ggggcugagc     2460

cccgccacga ccuacuacug ccgggugcag gcccuguccg ucgugggcgc cggccccuuc     2520

agcgaggugg ucgccugcgu gaccccgccc agcgugcccg ggaucgugac cugccuccag     2580

gagaucuccg acgacgagau cgagaacccc cacuacagcc ccuccacgug ccuggccauc     2640

agcugggaga agcccugcga ccacggcucc gagauccugg ccuacagcau cgacuucggg     2700

gacaagcagu cccugaccgu gggcaaggug accagcuaca ucaucaacaa ccuccagccg     2760

gacaccacgu accgcauccg gauccaggcg cugaacuccc ugggcgccgg gcccuucagc     2820

cacaugauca agcucaagac caagccccug ccgcccgacc cgccccgccu ggagugcguc     2880

gccuucuccc accagaaccu caagcugaag uggggcgagg ggacccccaa gacccugagc     2940

acggacucca uccaguacca ccuccagaug gaggacaaga acggccgguu cgugagccug     3000

uaccgcgggc ccugccacac cuacaaggug cagcggcuga acgaguccac cagcuacaag     3060

uucugcaucc aggccugcaa cgaggccggc gagggccccc ucucccagga guacaucuuc     3120

accacgccca agagcguccc ggcggcccug aaggccccca agaucgagaa ggugaacgac     3180

cacaucugcg agaucaccug ggagugccug cagcccauga agggggaccc cgugaucuac     3240

ucccuccagg ucaugcuggg caaggacagc gaguucaagc agaucuacaa ggggccggac     3300

agcuccuucc gcuacagcuc ccugcagcuc aacugcgagu accgguuccg cgugugcgcc     3360

auccggcagu gccaggacag ccugggccac caggaccugg uggggcccua cuccaccacc     3420

guccucuuca ucagccagcg cacggagccg cccgcgucca ccaaccggga caccguggag     3480

agcacccgca cgcgccgggc ccuguccgac gagcagugcg ccgccgugau ccugguccuc     3540

uucgccuucu ucagcauccu gaucgcguuc aucauccagu acuucgugau caaguga        3597


<210>  1584
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAX08808

<400>  1584
auggccgagc accccccccu ccucgacacc acccagaucc ucuccuccga caucucccuc       60

cucuccgccc ccaucgucuc cgccgacggc acccagcagg ucauccucgu ccaggucaac      120

cccggcgagg ccuucaccau ccgccgcgag gacggccagu uccagugcau caccggcccc      180

gcccaggucc ccaugauguc ccccaacggc uccguccccc ccaucuacgu cccccccggc      240

uacgcccccc aggucaucga ggacaacggc guccgccgcg ucgucgucgu cccccaggcc      300

cccgaguucc accccggcuc ccacaccguc cuccaccgcu ccccccaccc cccccucccc      360

ggcuucaucc ccguccccac caugaugccc cccccccccc gccacaugua cucccccguc      420

accggcgccg gcgacaugac cacccaguac augccccagu accaguccuc ccaggucuac      480

ggcgacgucg acgcccacuc cacccacggc cgcuccaacu uccgcgacga gcgcuccucc      540

aagaccuacg agcgccucca gaagaagcuc aaggaccgcc agggcaccca gaaggacaag      600

auguccuccc cccccuccuc cccccagaag ugccccuccc ccaucaacga gcacaacggc      660

cucaucaagg gccagaucgc cggcggcauc aacaccggcu ccgccaagau caaguccggc      720

aagggcaagg gcggcaccca ggucgacacc gagaucgagg agaaggacga ggagaccaag      780

gccuucgagg cccuccucuc caacaucguc aagcccgucg ccuccgacau ccaggcccgc      840

accgucgucc ucaccugguc cccccccucc ucccucauca acggcgagac cgacgagucc      900

uccguccccg agcucuacgg cuacgagguc cucaucuccu ccaccggcaa ggacggcaag      960

uacaaguccg ucuacgucgg cgaggagacc aacaucaccc ucaacgaccu caagcccgcc     1020

auggacuacc acgccaaggu ccaggccgag uacaacucca ucaagggcac ccccuccgag     1080

gccgagaucu ucaccacccu cuccugcgag cccgacaucc ccaacccccc ccgcaucgcc     1140

aaccgcacca agaacucccu cacccuccag uggaaggccc ccuccgacaa cggcuccaag     1200

auccagaacu ucguccucga gugggacgag ggcaagggca acggcgaguu cugccagugc     1260

uacaugggcu cccagaagca guucaagauc accaagcucu cccccgccau gggcugcaag     1320

uuccgccucu ccgcccgcaa cgacuacggc accuccggcu ucuccgagga gguccucuac     1380

uacaccuccg gcugcgcccc cuccaugccc gccucccccg uccucaccaa ggccggcauc     1440

accuggcucu cccuccagug guccaagccc uccggcaccc ccuccgacga gggcaucucc     1500

uacauccucg agauggagga ggagaccucc ggcuacggcu ucaagcccaa guacgacggc     1560

gaggaccucg ccuacaccgu caagaaccuc cgccgcucca ccaaguacaa guucaagguc     1620

aucgccuaca acuccgaggg caaguccaac cccuccgagg ucgucgaguu caccaccugc     1680

cccgacaagc ccggcauccc cgucaagccc uccgucaagg gcaagaucca cucccacucc     1740

uucaagauca ccugggaccc ccccaaggac aacggcggcg ccaccaucaa caaguacguc     1800

gucgagaugg ccgagggcuc caacggcaac aagugggaga ugaucuacuc cggcgccacc     1860

cgcgagcacc ucugcgaccg ccucaacccc ggcugcuucu accgccuccg cgucuacugc     1920

aucuccgacg gcggccaguc cgccgucucc gagucccucc ucguccagac ccccgccguc     1980

ccccccggcc ccugccuccc cccccgccuc cagggccgcc ccaaggccaa ggagauccag     2040

cuccgcuggg gccccccccu cgucgacggc ggcuccccca ucuccugcua cuccgucgag     2100

auguccccca ucgagaagga cgagccccgc gaggucuacc agggcuccga ggucgagugc     2160

accgucuccu cccuccuccc cggcaagacc uacuccuucc gccuccgcgc cgccaacaag     2220

augggcuucg gccccuucuc cgagaagugc gacaucacca ccgcccccgg cccccccgac     2280

cagugcaagc ccccccaggu caccugccgc uccgccaccu gcgcccaggu caacugggag     2340

gucccccucu ccaacggcac cgacgucacc gaguaccgcc ucgagugggg cggcgucgag     2400

ggcuccaugc agaucugcua cugcggcccc ggccucuccu acgagaucaa gggccucucc     2460

cccgccacca ccuacuacug ccgcguccag gcccucuccg ucgucggcgc cggccccuuc     2520

uccgaggucg ucgccugcgu cacccccccc uccguccccg gcaucgucac cugccuccag     2580

gagaucuccg acgacgagau cgagaacccc cacuacuccc ccuccaccug ccucgccauc     2640

uccugggaga agcccugcga ccacggcucc gagauccucg ccuacuccau cgacuucggc     2700

gacaagcagu cccucaccgu cggcaagguc accuccuaca ucaucaacaa ccuccagccc     2760

gacaccaccu accgcauccg cauccaggcc cucaacuccc ucggcgccgg ccccuucucc     2820

cacaugauca agcucaagac caagccccuc ccccccgacc ccccccgccu cgagugcguc     2880

gccuucuccc accagaaccu caagcucaag uggggcgagg gcacccccaa gacccucucc     2940

accgacucca uccaguacca ccuccagaug gaggacaaga acggccgcuu cgucucccuc     3000

uaccgcggcc ccugccacac cuacaagguc cagcgccuca acgaguccac cuccuacaag     3060

uucugcaucc aggccugcaa cgaggccggc gagggccccc ucucccagga guacaucuuc     3120

accaccccca aguccguccc cgccgcccuc aaggccccca agaucgagaa ggucaacgac     3180

cacaucugcg agaucaccug ggagugccuc cagcccauga agggcgaccc cgucaucuac     3240

ucccuccagg ucaugcucgg caaggacucc gaguucaagc agaucuacaa gggccccgac     3300

uccuccuucc gcuacuccuc ccuccagcuc aacugcgagu accgcuuccg cgucugcgcc     3360

auccgccagu gccaggacuc ccucggccac caggaccucg ucggccccua cuccaccacc     3420

guccucuuca ucucccagcg caccgagccc cccgccucca ccaaccgcga caccgucgag     3480

uccacccgca cccgccgcgc ccucuccgac gagcagugcg ccgccgucau ccucguccuc     3540

uucgccuucu ucuccauccu caucgccuuc aucauccagu acuucgucau caaguga        3597


<210>  1585
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAX08808

<400>  1585
auggccgagc aucccccucu gcucgacacc acacagaucc uuagcuccga uauuucucug       60

uugucagcuc caauagugag ugcagacggc acucaacagg ucaucuuagu ucaggugaac      120

ccgggggaag ccuucacgau uagaagggag gauggacagu uucaaugcau caccgguccc      180

gcgcagguac cuaugaugag cccaaauggc uccgugcccc cuauuuacgu cccacccggg      240

uaugcuccuc aggugaucga agacaacgga guucggcgcg uggucguggu accacaggcc      300

ccggaguucc accccggcuc ucacacaguu cugcaucgau cgccucaccc accccuaccu      360

gguuuuauac cagugcccac uaugaugccg ccucccccac gucauaugua cucaccuguc      420

accggggcag gagauaugac aacccaauau augccccagu accagagcag ucagguguau      480

ggcgacgugg augcccacuc cacucacggc agaucuaauu ucagggacga acggagcucc      540

aagacauacg agcgccucca aaagaagcug aaagauagac aggggaccca gaaggacaaa      600

augucaaguc cacccagcuc uccucaaaag uguccauccc cgaucaacga gcauaaugga      660

cuuauuaagg gucagaucgc uggcgggauu aacacgggau cagcaaaaau caagagcggc      720

aaagguaaag ggggaacuca ggucgauacc gaaauagagg aaaaagacga ggagacaaag      780

gccuuugaag cucuguugag uaauauuguu aagcccgugg ccucugauau ccaggcgagg      840

acuguagugc ucaccugguc cccuccaagc ucgcugauua acggcgagac agacgaaucu      900

uccguccccg agcuguaugg cuacgaagug cucaucucaa guaccgggaa agacggaaag      960

uacaaaagcg uuuauguggg ugaggagacg aauaucacuu uaaacgaucu gaagccugca     1020

auggacuacc acgccaaagu ccaagcugaa uauaauucca uuaagggcac accaucugag     1080

gccgaaauau ucaccacucu uagcugcgag cccgauaucc cgaacccucc acggauugca     1140

aaucgcacca aaaacucauu gacccugcag uggaaggcuc ccagugacaa uggguccaag     1200

auccagaacu uugugcuaga augggaugag ggaaaaggca acggugaguu cugucagugc     1260

uacaugggga gccaaaagca guuuaaaaua acgaagcucu cuccugccau gggcuguaaa     1320

uuccgacugu cagcgagaaa ugacuaugga accaguggcu uuagcgaaga gguacuuuac     1380

uauacauccg ggugcgcccc cucuaugcca gcaucgccug uucugacuaa ggcuggaauu     1440

accugguuga gccuccagug guccaagccc ucagguacac caagugauga aggcaucucu     1500

uacauccugg agauggaaga ggagacuagc ggguacggau ucaaaccgaa guaugacggc     1560

gaagauuuag ccuacaccgu gaaaaaccug aggcggucca caaaguauaa auuuaagguc     1620

auugcuuaca auucagaggg uaagagcaac ccuucugaag uggucgaguu caccacuugu     1680

cccgacaaac cagggauccc cgugaagccu uccguuaaag gcaagauuca uagucacagc     1740

uucaaaauaa cgugggaucc acccaaggac aauggaggcg ccacaaucaa caaguaugug     1800

guagagaugg cagaaggguc uaauggaaac aaaugggaga ugauuuacuc cggugccacc     1860

cgugaacacc ucugcgaccg ccuuaauccu ggcuguuuuu auagacugag ggucuacugc     1920

aucucagaug ggggacagag ugcugugagc gagucguugc uaguucaaac uccggcggug     1980

ccacccggcc cuugucugcc accccggcuc cagggucgac cuaaggcaaa agaaauccag     2040

cugcgcuggg ggccgccccu ugucgacggc ggauccccaa uuucuugcua cagcguggag     2100

augucaccua uagagaagga ugaacccaga gagguauauc agggcaguga aguggagugc     2160

accguuuccu cucuguugcc agggaaaaca uacagcuuca ggcuccgggc cgcuaacaag     2220

augggauuug gcccuuucuc cgaaaaaugu gacaucacca cugcccccgg uccaccggau     2280

caaugcaagc cuccccaggu cacaugucgc ucagcaacgu gcgcccaggu gaauugggag     2340

gugccacuga gcaacgggac cgacgucacu gaguauagau uagaaugggg aggcguugag     2400

gguaguaugc aaauuuguua cugcggcccc gggcugucuu augaaaucaa gggacuaucc     2460

ccugcuacaa ccuacuauug uagggugcag gcccucagcg ugguaggcgc agggccauuu     2520

ucggaggucg uggcgugcgu uacacccccu ucagugccgg gaauugucac uugucugcag     2580

gaaaucucug augacgagau agagaaucca cauuacaguc ccuccacaug ccuugcuauc     2640

agcugggaaa aaccuuguga ucacggcucu gagauuuugg ccuacagcau cgacuucggu     2700

gauaagcagu cccugacggu ggggaaaguu accucauaua uuaucaacaa ucuccaaccc     2760

gacacaacuu accguauacg gauucaggca cugaacaguc uuggagccgg cccauuuagc     2820

cauaugauca agcugaaaac caagccuuug cccccagauc cuccgcgacu cgaaugcgug     2880

gcuuucucuc accagaaccu gaaguuaaaa uggggugagg gcacacccaa gacucugucc     2940

accgacucaa uucaguauca ucuacaaaug gaggacaaaa augggagauu uguaagucuc     3000

uacaggggac caugccacac guauaagguc cagcgccuga acgaaagcac auccuacaaa     3060

uucuguaucc aggccugcaa ugaggcaggc gaagggccuc uuucucagga guauauauuu     3120

accacuccca agucggugcc agcugccuug aaggcgccua aaaucgaaaa ggugaacgau     3180

cacauuugug agaucacaug ggagugccug caacccauga aaggagaccc ggucauuuac     3240

agccuccagg uuaugcuggg caaggauuca gaguucaaac agaucuacaa ggguccagac     3300

uccaguuuuc gguauucuag cuuacaacug aauugugaau acagauucag ggugugcgcc     3360

auacgccagu gucaggauuc ccuugggcau caggacuugg uaggaccuua uucaaccacu     3420

guccucuuca uuucucaacg aaccgaaccc ccagcuagca caaaccggga uacgguggag     3480

aguacccgua cuagaagggc acuguccgac gaacagugcg ccgcugugau ccuaguucug     3540

uuugccuucu uuagcauccu cauugcauuc aucauucagu acuuugugau aaaguga        3597


<210>  1586
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAX08808

<400>  1586
auggccgagc accccccccu gcuggacacc acccagaucc ugagcagcga caucagccug       60

cugagcgccc ccaucgugag cgccgacggc acccagcagg ugauccuggu gcaggugaac      120

cccggcgagg ccuucaccau cagaagagag gacggccagu uccagugcau caccggcccc      180

gcccaggugc ccaugaugag ccccaacggc agcgugcccc ccaucuacgu gccccccggc      240

uacgcccccc aggugaucga ggacaacggc gugagaagag uggugguggu gccccaggcc      300

cccgaguucc accccggcag ccacaccgug cugcacagaa gcccccaccc cccccugccc      360

ggcuucaucc ccgugcccac caugaugccc ccccccccca gacacaugua cagccccgug      420

accggcgccg gcgacaugac cacccaguac augccccagu accagagcag ccagguguac      480

ggcgacgugg acgcccacag cacccacggc agaagcaacu ucagagacga gagaagcagc      540

aagaccuacg agagacugca gaagaagcug aaggacagac agggcaccca gaaggacaag      600

augagcagcc cccccagcag cccccagaag ugccccagcc ccaucaacga gcacaacggc      660

cugaucaagg gccagaucgc cggcggcauc aacaccggca gcgccaagau caagagcggc      720

aagggcaagg gcggcaccca gguggacacc gagaucgagg agaaggacga ggagaccaag      780

gccuucgagg cccugcugag caacaucgug aagcccgugg ccagcgacau ccaggccaga      840

accguggugc ugaccuggag cccccccagc agccugauca acggcgagac cgacgagagc      900

agcgugcccg agcuguacgg cuacgaggug cugaucagca gcaccggcaa ggacggcaag      960

uacaagagcg uguacguggg cgaggagacc aacaucaccc ugaacgaccu gaagcccgcc     1020

auggacuacc acgccaaggu gcaggccgag uacaacagca ucaagggcac ccccagcgag     1080

gccgagaucu ucaccacccu gagcugcgag cccgacaucc ccaacccccc cagaaucgcc     1140

aacagaacca agaacagccu gacccugcag uggaaggccc ccagcgacaa cggcagcaag     1200

auccagaacu ucgugcugga gugggacgag ggcaagggca acggcgaguu cugccagugc     1260

uacaugggca gccagaagca guucaagauc accaagcuga gccccgccau gggcugcaag     1320

uucagacuga gcgccagaaa cgacuacggc accagcggcu ucagcgagga ggugcuguac     1380

uacaccagcg gcugcgcccc cagcaugccc gccagccccg ugcugaccaa ggccggcauc     1440

accuggcuga gccugcagug gagcaagccc agcggcaccc ccagcgacga gggcaucagc     1500

uacauccugg agauggagga ggagaccagc ggcuacggcu ucaagcccaa guacgacggc     1560

gaggaccugg ccuacaccgu gaagaaccug agaagaagca ccaaguacaa guucaaggug     1620

aucgccuaca acagcgaggg caagagcaac cccagcgagg ugguggaguu caccaccugc     1680

cccgacaagc ccggcauccc cgugaagccc agcgugaagg gcaagaucca cagccacagc     1740

uucaagauca ccugggaccc ccccaaggac aacggcggcg ccaccaucaa caaguacgug     1800

guggagaugg ccgagggcag caacggcaac aagugggaga ugaucuacag cggcgccacc     1860

agagagcacc ugugcgacag acugaacccc ggcugcuucu acagacugag aguguacugc     1920

aucagcgacg gcggccagag cgccgugagc gagagccugc uggugcagac ccccgccgug     1980

ccccccggcc ccugccugcc ccccagacug cagggcagac ccaaggccaa ggagauccag     2040

cugagauggg gccccccccu gguggacggc ggcagcccca ucagcugcua cagcguggag     2100

augagcccca ucgagaagga cgagcccaga gagguguacc agggcagcga gguggagugc     2160

accgugagca gccugcugcc cggcaagacc uacagcuuca gacugagagc cgccaacaag     2220

augggcuucg gccccuucag cgagaagugc gacaucacca ccgcccccgg cccccccgac     2280

cagugcaagc ccccccaggu gaccugcaga agcgccaccu gcgcccaggu gaacugggag     2340

gugccccuga gcaacggcac cgacgugacc gaguacagac uggagugggg cggcguggag     2400

ggcagcaugc agaucugcua cugcggcccc ggccugagcu acgagaucaa gggccugagc     2460

cccgccacca ccuacuacug cagagugcag gcccugagcg uggugggcgc cggccccuuc     2520

agcgaggugg uggccugcgu gacccccccc agcgugcccg gcaucgugac cugccugcag     2580

gagaucagcg acgacgagau cgagaacccc cacuacagcc ccagcaccug ccuggccauc     2640

agcugggaga agcccugcga ccacggcagc gagauccugg ccuacagcau cgacuucggc     2700

gacaagcaga gccugaccgu gggcaaggug accagcuaca ucaucaacaa ccugcagccc     2760

gacaccaccu acagaaucag aauccaggcc cugaacagcc ugggcgccgg ccccuucagc     2820

cacaugauca agcugaagac caagccccug ccccccgacc cccccagacu ggagugcgug     2880

gccuucagcc accagaaccu gaagcugaag uggggcgagg gcacccccaa gacccugagc     2940

accgacagca uccaguacca ccugcagaug gaggacaaga acggcagauu cgugagccug     3000

uacagaggcc ccugccacac cuacaaggug cagagacuga acgagagcac cagcuacaag     3060

uucugcaucc aggccugcaa cgaggccggc gagggccccc ugagccagga guacaucuuc     3120

accaccccca agagcgugcc cgccgcccug aaggccccca agaucgagaa ggugaacgac     3180

cacaucugcg agaucaccug ggagugccug cagcccauga agggcgaccc cgugaucuac     3240

agccugcagg ugaugcuggg caaggacagc gaguucaagc agaucuacaa gggccccgac     3300

agcagcuuca gauacagcag ccugcagcug aacugcgagu acagauucag agugugcgcc     3360

aucagacagu gccaggacag ccugggccac caggaccugg ugggccccua cagcaccacc     3420

gugcuguuca ucagccagag aaccgagccc cccgccagca ccaacagaga caccguggag     3480

agcaccagaa ccagaagagc ccugagcgac gagcagugcg ccgccgugau ccuggugcug     3540

uucgccuucu ucagcauccu gaucgccuuc aucauccagu acuucgugau caaguga        3597


<210>  1587
<211>  3597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAX08808

<400>  1587
auggccgagc aucccccucu gcucgacacc acacagaucc ugagcuccga uauuucucuu       60

cugagcgcuc cgaucguguc cgccgacggc acgcaacagg ucauucucgu ucaggugaac      120

cccggggaag cguucaccau cagacgggag gauggacagu uucaaugcau uacaggcccu      180

gcucaggugc ccaugauguc uccuaauggg agcgugcccc cuaucuacgu cccgcccgga      240

uaugccccuc agguuaucga agacaacggc gugcgcagag ucgugguugu gccccaggcc      300

ccugaguucc accccggguc ccacaccguc cugcaucggu cuccgcaccc uccccuuccu      360

ggauuuauuc ccgugcccac aaugaugccu ccgcccccuc gccauaugua cagccccgug      420

accggcgcug gcgauaugac aacccaauau augccucagu accaguccag ccaggucuau      480

ggggacguug augcccacuc uacgcacgga agauccaauu uccgggacga acgcagcucu      540

aagaccuacg agagacugca aaagaagcuc aaagaucggc agggcacaca gaaggacaaa      600

auguccucuc ccccgagcuc cccucaaaag ugucccagcc cuaucaacga gcauaauggg      660

cugauuaagg gacagaucgc uggcgggauu aacaccggau ccgccaaaau caagucuggc      720

aaaggcaaag ggggaacaca gguggauacc gaaauugagg aaaaagacga ggagacgaag      780

gcguuugaag cccugcucag caauaucgug aagcccgucg cuuccgauau ccaggcccgc      840

acagugguuc ugaccuggag cccucccucu ucccuuauua acggcgagac agacgaaagc      900

ucugugccgg agcuguaugg guacgaaguc cucaucagcu ccaccggaaa agacggcaag      960

uacaaaucug uguauguugg ggaggagacc aauauuacac ugaacgaucu uaagccugcu     1020

auggacuacc acgccaaagu gcaagcggaa uauaauagca ucaagggaac gcccuccgag     1080

gccgaaauuu ucaccacacu gagcugcgag cccgauaucc cuaacccgcc cagaaucgcu     1140

aaucggacca aaaacucucu cacacugcag uggaaggccc cuuccgacaa uggcagcaag     1200

auucagaacu uuguccugga augggaugag ggcaaaggga acggagaguu cugucagugc     1260

uacaugggcu cucaaaagca guuuaaaauc accaagcucu cccccgcuau gggguguaaa     1320

uuccgccuga gcgccagaaa ugacuaugga acguccggcu uuucugaaga ggugcuuuac     1380

uauacaagcg ggugcgcccc uuccaugccc gcuucuccug uccugaccaa ggcgggcauu     1440

accuggcuca gccugcagug guccaagccc agcggaacac cgucugauga aggcaucucc     1500

uacauucuug agauggaaga ggagaccagc ggguacggau ucaaaccuaa guaugacggc     1560

gaagaucugg ccuacacagu gaaaaaccuc cggcgcucua cgaaguauaa auuuaagguu     1620

aucgcuuaca auuccgaggg aaagagcaac cccucugaag uggucgaguu caccacaugu     1680

ccugacaaac ccgggauccc ggugaagccu agcguuaaag gcaagauuca uucccacagc     1740

uucaaaauca ccugggaucc cccuaaggac aaugggggcg ccacaauuaa caaguaugug     1800

gucgagaugg ccgaaggauc uaauggcaac aaaugggaga ugaucuacuc cggggcuacc     1860

agagaacacc ugugcgaccg gcugaauccc ggauguuuuu auagacuccg cguguacugc     1920

auuagcgaug gcgggcaguc cgccgugucu gagagccugc uuguucaaac gcccgcgguc     1980

ccuccgggac ccugucugcc uccccggcuc cagggcagac cuaaggcuaa agaaauccag     2040

cugcgcuggg ggcccccucu uguggacggc ggauccccga uuucuugcua cagcguggag     2100

auguccccca ucgagaagga ugaaccucgg gaggucuauc agggcucuga aguggagugc     2160

accguuagcu cccugcuccc cgggaaaaca uacagcuuca gacugcgcgc cgccaacaag     2220

augggauuug gcccuuucuc ugaaaaaugu gacaucacca cagcucccgg gccgccugau     2280

caaugcaagc cuccccaggu gaccugucgg uccgccacgu gcgcucaggu caauugggag     2340

gugccccuga gcaacggaac agacguuacc gaguauagac ucgaaugggg cgggguggag     2400

ggcucuaugc aaauuuguua cugcggaccc ggccuguccu augaaaucaa ggggcuuagc     2460

ccugccacaa ccuacuauug ucgcguccag gcgcugucug ugguuggagc cggcccguuu     2520

uccgaggugg ucgcuugcgu gacacccccu agcgugcccg ggauugucac cugucuccag     2580

gaaaucuccg augacgagau ugagaauccu cauuacagcc ccucuacgug ccuggccauc     2640

agcugggaaa aaccguguga ucacggaucc gagauccugg cuuacucuau ugacuucggc     2700

gauaagcaga gccuuaccgu uggcaaagug acauccuaua ucauuaacaa ucuccaaccu     2760

gacaccacau accggauccg cauucaggcc cugaacucuc ugggggcggg acccuuuagc     2820

cauaugauca agcucaaaac caagccucug cccccugauc ccccgagacu ugaaugcgug     2880

gccuucuccc accagaaccu gaagcucaaa uggggcgagg ggacgccuaa gacacugucu     2940

accgacagca uccaguauca ucugcaaaug gaggacaaaa auggacgguu ugucucccuu     3000

uacagaggcc ccugccacac cuauaaggug cagcggcuca acgaaagcac aucuuacaaa     3060

uucuguauuc aggcuugcaa ugaggccggg gaaggacccc ugucccagga guauaucuuu     3120

accacaccua agagcguucc ggcugcccug aaggccccca aaauugaaaa ggugaacgau     3180

cacaucugug agauuacgug ggagugccuc caaccuauga aaggcgaccc cgucaucuac     3240

ucucuucagg ugaugcuggg caaggauucc gaguucaaac agaucuacaa ggggccugac     3300

agcuccuuuc gcuauucuag ccugcaacuc aauugugaau acagauuccg gguuugcgcu     3360

auuagacagu gucaggauuc ccugggacau caggaccugg ugggccccua uagcaccaca     3420

guccuuuuca ucucucaacg caccgaaccu ccggcgucca caaaccggga uaccguggag     3480

agcacgagaa cccgcagagc ccucucugac gaacagugcg cugccguuau ucuggugcug     3540

uuugccuucu uuagcauccu cauugcuuuc aucauucagu acuuugucau caaguga        3597


<210>  1588
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A0A024RDV5

<400>  1588

Met Ser Gly Pro Ala Gln Val Pro Met Met Ser Pro Asn Gly Ser Val 
1               5                   10                  15      


Pro Pro Ile Tyr Val Pro Pro Gly Tyr Ala Pro Gln Val Ile Glu Asp 
            20                  25                  30          


Asn Gly Val Arg Arg Val Val Val Val Pro Gln Ala Pro Glu Phe His 
        35                  40                  45              


Pro Gly Ser His Thr Val Leu His Arg Ser Pro His Pro Pro Leu Pro 
    50                  55                  60                  


Gly Phe Ile Pro Val Pro Thr Met Met Pro Pro Pro Pro Arg His Met 
65                  70                  75                  80  


Tyr Ser Pro Val Thr Gly Ala Gly Asp Met Thr Thr Gln Tyr Met Pro 
                85                  90                  95      


Gln Tyr Gln Ser Ser Gln Val Tyr Gly Asp Val Asp Ala His Ser Thr 
            100                 105                 110         


His Gly Arg Ser Asn Phe Arg Asp Glu Arg Ser Ser Lys Thr Tyr Glu 
        115                 120                 125             


Arg Leu Gln Lys Lys Leu Lys Asp Arg Gln Gly Thr Gln Lys Asp Lys 
    130                 135                 140                 


Met Ser Ser Pro Pro Ser Ser Pro Gln Lys Cys Pro Ser Pro Ile Asn 
145                 150                 155                 160 


Glu His Asn Gly Leu Ile Lys Gly Gln Ile Ala Gly Gly Ile Asn Thr 
                165                 170                 175     


Gly Ser Ala Lys Ile Lys Ser Gly Lys Gly Lys Gly Gly Thr Gln Val 
            180                 185                 190         


Asp Thr Glu Ile Glu Glu Lys Asp Glu Glu Thr Lys Ala Phe Glu Ala 
        195                 200                 205             


Leu Leu Ser Asn Ile Val Lys Pro Val Ala Ser Asp Ile Gln Ala Arg 
    210                 215                 220                 


Thr Val Val Leu Thr Trp Ser Pro Pro Ser Ser Leu Ile Asn Gly Glu 
225                 230                 235                 240 


Thr Asp Glu Ser Ser Val Pro Glu Leu Tyr Gly Tyr Glu Val Leu Ile 
                245                 250                 255     


Ser Ser Thr Gly Lys Asp Gly Lys Tyr Lys Ser Val Tyr Val Gly Glu 
            260                 265                 270         


Glu Thr Asn Ile Thr Leu Asn Asp Leu Lys Pro Ala Met Asp Tyr His 
        275                 280                 285             


Ala Lys Val Gln Ala Glu Tyr Asn Ser Ile Lys Gly Thr Pro Ser Glu 
    290                 295                 300                 


Ala Glu Ile Phe Thr Thr Leu Ser Cys Glu Pro Asp Ile Pro Asn Pro 
305                 310                 315                 320 


Pro Arg Ile Ala Asn Arg Thr Lys Asn Ser Leu Thr Leu Gln Trp Lys 
                325                 330                 335     


Ala Pro Ser Asp Asn Gly Ser Lys Ile Gln Asn Phe Val Leu Glu Trp 
            340                 345                 350         


Asp Glu Gly Lys Gly Asn Gly Glu Phe Cys Gln Cys Tyr Met Gly Ser 
        355                 360                 365             


Gln Lys Gln Phe Lys Ile Thr Lys Leu Ser Pro Ala Met Gly Cys Lys 
    370                 375                 380                 


Phe Arg Leu Ser Ala Arg Asn Asp Tyr Gly Thr Ser Gly Phe Ser Glu 
385                 390                 395                 400 


Glu Val Leu Tyr Tyr Thr Ser Gly Cys Ala Pro Ser Met Pro Ala Ser 
                405                 410                 415     


Pro Val Leu Thr Lys Ala Gly Ile Thr Trp Leu Ser Leu Gln Trp Ser 
            420                 425                 430         


Lys Pro Ser Gly Thr Pro Ser Asp Glu Gly Ile Ser Tyr Ile Leu Glu 
        435                 440                 445             


Met Glu Glu Glu Thr Ser Gly Tyr Gly Phe Lys Pro Lys Tyr Asp Gly 
    450                 455                 460                 


Glu Asp Leu Ala Tyr Thr Val Lys Asn Leu Arg Arg Ser Thr Lys Tyr 
465                 470                 475                 480 


Lys Phe Lys Val Ile Ala Tyr Asn Ser Glu Gly Lys Ser Asn Pro Ser 
                485                 490                 495     


Glu Val Val Glu Phe Thr Thr Cys Pro Asp Lys Pro Gly Ile Pro Val 
            500                 505                 510         


Lys Pro Ser Val Lys Gly Lys Ile His Ser His Ser Phe Lys Ile Thr 
        515                 520                 525             


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ala Thr Ile Asn Lys Tyr Val 
    530                 535                 540                 


Val Glu Met Ala Glu Gly Ser Asn Gly Asn Lys Trp Glu Met Ile Tyr 
545                 550                 555                 560 


Ser Gly Ala Thr Arg Glu His Leu Cys Asp Arg Leu Asn Pro Gly Cys 
                565                 570                 575     


Phe Tyr Arg Leu Arg Val Tyr Cys Ile Ser Asp Gly Gly Gln Ser Ala 
            580                 585                 590         


Val Ser Glu Ser Leu Leu Val Gln Thr Pro Ala Val Pro Pro Gly Pro 
        595                 600                 605             


Cys Leu Pro Pro Arg Leu Gln Gly Arg Pro Lys Ala Lys Glu Ile Gln 
    610                 615                 620                 


Leu Arg Trp Gly Pro Pro Leu Val Asp Gly Gly Ser Pro Ile Ser Cys 
625                 630                 635                 640 


Tyr Ser Val Glu Met Ser Pro Ile Glu Lys Asp Glu Pro Arg Glu Val 
                645                 650                 655     


Tyr Gln Gly Ser Glu Val Glu Cys Thr Val Ser Ser Leu Leu Pro Gly 
            660                 665                 670         


Lys Thr Tyr Ser Phe Arg Leu Arg Ala Ala Asn Lys Met Gly Phe Gly 
        675                 680                 685             


Pro Phe Ser Glu Lys Cys Asp Ile Thr Thr Ala Pro Gly Pro Pro Asp 
    690                 695                 700                 


Gln Cys Lys Pro Pro Gln Val Thr Cys Arg Ser Ala Thr Cys Ala Gln 
705                 710                 715                 720 


Val Asn Trp Glu Val Pro Leu Ser Asn Gly Thr Asp Val Thr Glu Tyr 
                725                 730                 735     


Arg Leu Glu Trp Gly Gly Val Glu Gly Ser Met Gln Ile Cys Tyr Cys 
            740                 745                 750         


Gly Pro Gly Leu Ser Tyr Glu Ile Lys Gly Leu Ser Pro Ala Thr Thr 
        755                 760                 765             


Tyr Tyr Cys Arg Val Gln Ala Leu Ser Val Val Gly Ala Gly Pro Phe 
    770                 775                 780                 


Ser Glu Val Val Ala Cys Val Thr Pro Pro Ser Val Pro Gly Ile Val 
785                 790                 795                 800 


Thr Cys Leu Gln Glu Ile Ser Asp Asp Glu Ile Glu Asn Pro His Tyr 
                805                 810                 815     


Ser Pro Ser Thr Cys Leu Ala Ile Ser Trp Glu Lys Pro Cys Asp His 
            820                 825                 830         


Gly Ser Glu Ile Leu Ala Tyr Ser Ile Asp Phe Gly Asp Lys Gln Ser 
        835                 840                 845             


Leu Thr Val Gly Lys Val Thr Ser Tyr Ile Ile Asn Asn Leu Gln Pro 
    850                 855                 860                 


Asp Thr Thr Tyr Arg Ile Arg Ile Gln Ala Leu Asn Ser Leu Gly Ala 
865                 870                 875                 880 


Gly Pro Phe Ser His Met Ile Lys Leu Lys Thr Lys Pro Leu Pro Pro 
                885                 890                 895     


Asp Pro Pro Arg Leu Glu Cys Val Ala Phe Ser His Gln Asn Leu Lys 
            900                 905                 910         


Leu Lys Trp Gly Glu Gly Thr Pro Lys Thr Leu Ser Thr Asp Ser Ile 
        915                 920                 925             


Gln Tyr His Leu Gln Met Glu Asp Lys Asn Gly Arg Phe Val Ser Leu 
    930                 935                 940                 


Tyr Arg Gly Pro Cys His Thr Tyr Lys Val Gln Arg Leu Asn Glu Ser 
945                 950                 955                 960 


Thr Ser Tyr Lys Phe Cys Ile Gln Ala Cys Asn Glu Ala Gly Glu Gly 
                965                 970                 975     


Pro Leu Ser Gln Glu Tyr Ile Phe Thr Thr Pro Lys Ser Val Pro Ala 
            980                 985                 990         


Ala Leu Lys Ala Pro Lys Ile Glu Lys Val Asn Asp His Ile Cys Glu 
        995                 1000                1005            


Ile Thr Trp Glu Cys Leu Gln Pro Met Lys Gly Asp Pro Val Ile Tyr 
    1010                1015                1020                


Ser Leu Gln Val Met Leu Gly Lys Asp Ser Glu Phe Lys Gln Ile Tyr 
1025                1030                1035                1040


Lys Gly Pro Asp Ser Ser Phe Arg Tyr Ser Ser Leu Gln Leu Asn Cys 
                1045                1050                1055    


Glu Tyr Arg Phe Arg Val Cys Ala Ile Arg Gln Cys Gln Asp Ser Leu 
            1060                1065                1070        


Gly His Gln Asp Leu Val Gly Pro Tyr Ser Thr Thr Val Leu Phe Ile 
        1075                1080                1085            


Ser Gln Arg Thr Glu Pro Pro Ala Ser Thr Asn Arg Asp Thr Val Glu 
    1090                1095                1100                


Ser Thr Arg Thr Arg Arg Ala Leu Ser Asp Glu Gln Cys Ala Ala Val 
1105                1110                1115                1120


Ile Leu Val Leu Phe Ala Phe Phe Ser Ile Leu Ile Ala Phe Ile Ile 
                1125                1130                1135    


Gln Tyr Phe Val Ile Lys 
            1140        


<210>  1589
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAX08809

<400>  1589
augagugguc cugcucaggu uccaaugaug uccccaaaug guucugugcc uccuaucuau       60

gugccuccug gauaugcccc acagguuauu gaagacaaug guguucgaag aguugucgug      120

gucccucagg caccagaguu ucacccuggu agucacacag uucuccaccg uucuccacau      180

ccuccucuac cugguuucau uccuguccca acuaugaugc cgccuccacc acgucauaug      240

uacucacccg ugacuggagc uggagacaug acaacacagu auaugccaca guaucagucu      300

ucacaagucu auggagaugu agaugcucac ucuacacaug gaagguccaa cuuuagagau      360

gaacgaucua guaaaacaua ugaacguuug cagaaaaaau ugaaggaucg ccaaggaaca      420

cagaaagaua aaaugagcag uccaccauca ucaccccaga aaugcccuuc ucccauuaau      480

gaacauaaug gacuuauaaa aggacaaauu gcugguggua uaaacacagg aucagcaaaa      540

aucaagucug ggaaggggaa aggugguaca caaguugaua cagaaauuga agaaaaagau      600

gaagaaacua aagcauuuga agcacuucuu uccaacauug ucaaaccagu ggccuccgac      660

auccaggcaa ggacaguagu acuuaccugg ucaccaccuu ccagccucau uaauggugaa      720

acagaugaaa guaguguacc agagcucuau gguuaugaag uucugaucuc aaguacugga      780

aaagauggga aauacaaaag uguauaugua ggagaagaaa caaauaucac uuuaaaugau      840

cucaagccag ccauggauua ccaugcaaaa guccaggcag aauauaauuc uauaaaggga      900

acuccuucag aggcugaaau cuuuaccacc uugagcugug aaccugauau accuaaucca      960

ccaaggauag ccaaucggac caaaaauuca cucacuuugc aauggaaggc accuagugac     1020

aaugguucua aaauccaaaa cuuuguauua gaaugggaug aaggaaaagg aaauggagaa     1080

uuuugucagu guuacauggg cucacagaaa caauuuaaaa uuacuaaacu uucaccagca     1140

augggcugua aauucagacu aucggccaga aaugacuaug guacaagugg uuuuagugaa     1200

gaagucuuau auuacaccuc aggcugugcu ccuucuaugc cagcaagucc uguauuaacc     1260

aaggcuggaa uuacuugguu auccuuacaa uggaguaagc ccucaggaac accaucagau     1320

gaaggaauuu cuuacauuuu agagauggag gaagaaacuu caggauaugg uuuuaagccu     1380

aaauaugaug gagaagaucu ugcuuacaca gugaaaaauc ucagacguag uacuaaguau     1440

aaauuuaagg uuauugcuua caacucagaa gguaaaagua auccaaguga aguaguagaa     1500

uuuacuacuu gcccugauaa accaggcaua ccuguaaagc cuucagugaa aggaaagaua     1560

cauucacaca guuuuaaaau aaccugggau ccaccaaaag acaauggcgg agcaaccauc     1620

aauaaauaug uaguggagau ggcagaaggu ucuaacggaa acaaauggga aaugauauac     1680

aguggugcua ccagggaaca ucuuugugau cgacugaauc caggcuguuu cuaucguuua     1740

cgaguuuacu gcaucaguga uggaggacag agugcggucu cugaaucuuu acuugugcag     1800

acuccagcug ugccuccugg cccaugccuc ccucccagau uacaggguag acccaaagca     1860

aaagaaauac aguuacgaug gggacccccu cugguugaug guggaucacc cauuuccugu     1920

uacagugugg aaaugucucc uauagaaaaa gaugaaccua gagaaguuua ccaagguucu     1980

gaaguagaau guacagugag cagccuucuu ccuggaaaga cauacagcuu cagacuacgu     2040

gcagcuaaca aaaugggguu uggaccauuu ucagaaaaau gugauauuac uacagccccu     2100

gggccaccag aucagugcaa gcccccucaa gugacaugua gaucugcaac uugugcacaa     2160

gugaauuggg agguuccuuu gaguaaugga acagauguca cugaauaucg acuggagugg     2220

ggaggaguug aaggaaguau gcagauaugu uacugugggc cuggucucag uuaugaaaua     2280

aaaggacuuu caccagcaac uaccuauuau ugcagggucc aggcucugag uguugugggu     2340

gcaggcccuu ucagugaagu aguagccugu gugacuccac caucaguucc uggcauugug     2400

accugucuuc aagaaauaag cgaugaugag auagaaaauc cccauuauuc accuucuaca     2460

ugccuugcaa uaagcuggga aaagccuugu gaucaugguu cggaaauccu ugccuacagc     2520

auagacuuug gagauaaaca aucccuaaca gugggaaagg uuacaagcua uauuaucaac     2580

aauuugcaac cagauacaac auacagaaua cgaauucaag ccuugaauag ccuuggagcu     2640

gguccuuuca gccauaugau aaaauuaaaa acuaagccuc ucccuccuga uccaccucgu     2700

cuggaaugug uugccuuuag ccaccagaac cuuaagcuga aauggggaga aggaacucca     2760

aagacauugu caaccgauuc uauucaguac caccuucaga uggaggauaa gaauggacgg     2820

uuuguauccc uauacagagg accaugucau acauacaaag uacaaagacu uaaugaguca     2880

acauccuaua aauucuguau ucaagcuugu aaugaagcug gggaaggucc ccucucccaa     2940

gaauauauuu ucacuacucc aaaaucuguc ccagcugccu ugaaagcccc caaaauagag     3000

aaaguaaaug aucacauuug ugaaauuaca ugggaguguu uacagccaau gaaaggugau     3060

ccaguuauuu acagucuuca aguuauguug ggaaaagauu cagaauucaa acagauuuac     3120

aagggucccg acucuuccuu ccgguauucc agccuucagc ugaacuguga auaucgcuuc     3180

cguguaugug ccauucgcca gugccaagac ucucugggac accaggaccu cguagguccc     3240

uacagcacca cagugcucuu caucucucag aggacugaac caccagccag caccaacaga     3300

gacacugugg aaagcacaag gacccgacgg gcacugagug acgagcagug ugcugccguc     3360

auccuugugc uguuugcuuu cuuuuccauu uugauugccu uuaucauuca guacuuugua     3420

aucaaguga                                                             3429


<210>  1590
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAX08809

<400>  1590
augagcggcc ccgcccaggu gcccaugaug ucccccaacg ggagcguccc gcccaucuac       60

gugccgcccg gcuacgcgcc ccaggugauc gaggacaacg ggguccgccg gguggugguc      120

gugccccagg cccccgaguu ccaccccggc ucccacaccg ugcugcaccg cagcccccac      180

ccgccccucc ccggguucau ccccgucccc accaugaugc cgcccccgcc ccggcacaug      240

uacucccccg ugacgggcgc cggcgacaug accacccagu acaugcccca guaccagagc      300

ucccaggugu acggggacgu cgacgcccac agcacccacg gccgcuccaa cuuccgggac      360

gagcgcagcu ccaagacgua cgagcggcug cagaagaagc ugaaggaccg ccaggggacc      420

cagaaggaca agaugagcuc cccgcccagc agcccccaga agugccccuc ccccaucaac      480

gagcacaacg gccucaucaa ggggcagauc gccggcggca ucaacaccgg guccgccaag      540

aucaagagcg gcaaggggaa gggcggcacc cagguggaca cggagaucga ggagaaggac      600

gaggagacca aggcguucga ggcccugcug uccaacaucg ugaagcccgu cgccagcgac      660

auccaggccc ggaccguggu gcucaccugg agcccgcccu ccagccugau caacggggag      720

acggacgagu ccagcguccc cgagcuguac ggcuacgagg ugcucaucuc cagcaccggg      780

aaggacggca aguacaaguc cguguacguc ggggaggaga ccaacaucac ccugaacgac      840

cugaagccgg cgauggacua ccacgccaag gugcaggccg aguacaacag caucaagggc      900

acgcccuccg aggccgagau cuucaccacc cucagcugcg agcccgacau ccccaacccg      960

ccccgcaucg ccaaccggac caagaacucc cugacgcugc aguggaaggc gcccagcgac     1020

aacggcucca agauccagaa cuucgugcuc gagugggacg aggggaaggg caacggggag     1080

uucugccagu gcuacauggg cagccagaag caguucaaga ucaccaagcu gucccccgcc     1140

auggggugca aguuccgccu gagcgcccgg aacgacuacg gcaccuccgg cuucagcgag     1200

gagguccucu acuacaccuc cgggugcgcc ccgagcaugc ccgccagccc cgugcugacg     1260

aaggcgggca ucaccuggcu gucccuccag uggagcaagc ccuccgggac cccgagcgac     1320

gagggcaucu ccuacauccu ggagauggag gaggagacca gcggguacgg cuucaagccc     1380

aaguacgacg gcgaggaccu ggccuacacg gucaagaacc uccgccgguc caccaaguac     1440

aaguucaagg ugaucgccua caacagcgag gggaagucca accccagcga gguggucgag     1500

uucacgaccu gccccgacaa gccgggcauc cccgugaagc ccuccgugaa ggggaagauc     1560

cacagccacu ccuucaagau caccugggac ccgcccaagg acaacggcgg cgccaccauc     1620

aacaaguacg ucguggagau ggccgagggg agcaacggca acaaguggga gaugaucuac     1680

uccggggcga cccgcgagca ccugugcgac cggcugaacc ccggcugcuu cuaccgccuc     1740

cggguguacu gcaucagcga cgggggccag uccgccguca gcgagagccu gcuggugcag     1800

acccccgccg ugcccccggg ccccugccug cccccgcgcc uccaggggcg gcccaaggcc     1860

aaggagaucc agcugcgcug gggcccgccc cucgucgacg ggggcucccc caucagcugc     1920

uacuccgugg agaugagccc caucgagaag gacgagcccc gcgaggugua ccaggggucc     1980

gaggucgagu gcacggugag cucccugcug cccggcaaga ccuacagcuu ccggcuccgc     2040

gccgcgaaca agaugggcuu cgggccguuc uccgagaagu gcgacaucac caccgccccc     2100

ggcccgcccg accagugcaa gccgccccag gugaccugcc ggagcgccac gugcgcccag     2160

gucaacuggg aggugccccu guccaacggg accgacguga ccgaguaccg ccuggagugg     2220

ggcggggucg agggcagcau gcagaucugc uacugcggcc ccgggcucuc cuacgagauc     2280

aagggccuga gccccgcgac cacguacuac ugccgggugc aggcccuguc cguggucggg     2340

gccggccccu ucagcgaggu gguggccugc gucaccccgc ccuccgugcc cgggaucgug     2400

accugccucc aggagaucag cgacgacgag aucgagaacc cccacuacuc ccccuccacg     2460

ugccuggcca ucagcuggga gaagcccugc gaccacggca gcgagauccu ggcguacagc     2520

aucgacuucg gcgacaagca gucccucacc gucgggaagg ugaccagcua caucaucaac     2580

aaccugcagc cggacaccac cuaccgcauc cggauccagg cccugaacuc ccucggcgcc     2640

gggcccuuca gccacaugau caagcugaag acgaagcccc ugcccccgga cccgccccgc     2700

cuggagugcg uggccuucuc ccaccagaac cucaagcuga aguggggcga gggcaccccc     2760

aagacccuga gcaccgacuc cauccaguac caccuccaga uggaggacaa gaacgggcgg     2820

uucgucagcc uguaccgcgg ccccugccac acguacaagg ugcagcggcu gaacgagucc     2880

accagcuaca aguucugcau ccaggccugc aacgaggcgg gggagggccc ccucucccag     2940

gaguacaucu ucaccacccc caagagcgug ccggccgccc ugaaggcccc caagaucgag     3000

aaggucaacg accacaucug cgagaucacg ugggagugcc ugcagcccau gaagggggac     3060

cccgugaucu acucccucca ggugaugcug ggcaaggaca gcgaguucaa gcagaucuac     3120

aagggcccgg acuccagcuu ccgcuacucc agccugcagc ucaacugcga guaccgguuc     3180

cgcgucugcg ccauccggca gugccaggac agccuggggc accaggaccu ggugggcccc     3240

uacuccacca ccguccucuu caucagccag cgcaccgagc cgcccgcguc cacgaaccgg     3300

gacaccgugg agagcacccg cacccggcgc gcccuguccg acgagcagug cgccgccgug     3360

auccuggucc ucuucgcguu cuucagcauc cugaucgccu ucaucaucca guacuucgug     3420

aucaaguga                                                             3429


<210>  1591
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAX08809

<400>  1591
auguccggcc ccgcccaggu ccccaugaug ucccccaacg gcuccguccc ccccaucuac       60

gucccccccg gcuacgcccc ccaggucauc gaggacaacg gcguccgccg cgucgucguc      120

gucccccagg cccccgaguu ccaccccggc ucccacaccg uccuccaccg cuccccccac      180

cccccccucc ccggcuucau ccccgucccc accaugaugc cccccccccc ccgccacaug      240

uacucccccg ucaccggcgc cggcgacaug accacccagu acaugcccca guaccagucc      300

ucccaggucu acggcgacgu cgacgcccac uccacccacg gccgcuccaa cuuccgcgac      360

gagcgcuccu ccaagaccua cgagcgccuc cagaagaagc ucaaggaccg ccagggcacc      420

cagaaggaca agauguccuc cccccccucc uccccccaga agugccccuc ccccaucaac      480

gagcacaacg gccucaucaa gggccagauc gccggcggca ucaacaccgg cuccgccaag      540

aucaaguccg gcaagggcaa gggcggcacc caggucgaca ccgagaucga ggagaaggac      600

gaggagacca aggccuucga ggcccuccuc uccaacaucg ucaagcccgu cgccuccgac      660

auccaggccc gcaccgucgu ccucaccugg uccccccccu ccucccucau caacggcgag      720

accgacgagu ccuccguccc cgagcucuac ggcuacgagg uccucaucuc cuccaccggc      780

aaggacggca aguacaaguc cgucuacguc ggcgaggaga ccaacaucac ccucaacgac      840

cucaagcccg ccauggacua ccacgccaag guccaggccg aguacaacuc caucaagggc      900

acccccuccg aggccgagau cuucaccacc cucuccugcg agcccgacau ccccaacccc      960

ccccgcaucg ccaaccgcac caagaacucc cucacccucc aguggaaggc ccccuccgac     1020

aacggcucca agauccagaa cuucguccuc gagugggacg agggcaaggg caacggcgag     1080

uucugccagu gcuacauggg cucccagaag caguucaaga ucaccaagcu cucccccgcc     1140

augggcugca aguuccgccu cuccgcccgc aacgacuacg gcaccuccgg cuucuccgag     1200

gagguccucu acuacaccuc cggcugcgcc cccuccaugc ccgccucccc cguccucacc     1260

aaggccggca ucaccuggcu cucccuccag ugguccaagc ccuccggcac ccccuccgac     1320

gagggcaucu ccuacauccu cgagauggag gaggagaccu ccggcuacgg cuucaagccc     1380

aaguacgacg gcgaggaccu cgccuacacc gucaagaacc uccgccgcuc caccaaguac     1440

aaguucaagg ucaucgccua caacuccgag ggcaagucca accccuccga ggucgucgag     1500

uucaccaccu gccccgacaa gcccggcauc cccgucaagc ccuccgucaa gggcaagauc     1560

cacucccacu ccuucaagau caccugggac ccccccaagg acaacggcgg cgccaccauc     1620

aacaaguacg ucgucgagau ggccgagggc uccaacggca acaaguggga gaugaucuac     1680

uccggcgcca cccgcgagca ccucugcgac cgccucaacc ccggcugcuu cuaccgccuc     1740

cgcgucuacu gcaucuccga cggcggccag uccgccgucu ccgagucccu ccucguccag     1800

acccccgccg ucccccccgg ccccugccuc cccccccgcc uccagggccg ccccaaggcc     1860

aaggagaucc agcuccgcug gggccccccc cucgucgacg gcggcucccc caucuccugc     1920

uacuccgucg agaugucccc caucgagaag gacgagcccc gcgaggucua ccagggcucc     1980

gaggucgagu gcaccgucuc cucccuccuc cccggcaaga ccuacuccuu ccgccuccgc     2040

gccgccaaca agaugggcuu cggccccuuc uccgagaagu gcgacaucac caccgccccc     2100

ggcccccccg accagugcaa gcccccccag gucaccugcc gcuccgccac cugcgcccag     2160

gucaacuggg aggucccccu cuccaacggc accgacguca ccgaguaccg ccucgagugg     2220

ggcggcgucg agggcuccau gcagaucugc uacugcggcc ccggccucuc cuacgagauc     2280

aagggccucu cccccgccac caccuacuac ugccgcgucc aggcccucuc cgucgucggc     2340

gccggccccu ucuccgaggu cgucgccugc gucacccccc ccuccguccc cggcaucguc     2400

accugccucc aggagaucuc cgacgacgag aucgagaacc cccacuacuc ccccuccacc     2460

ugccucgcca ucuccuggga gaagcccugc gaccacggcu ccgagauccu cgccuacucc     2520

aucgacuucg gcgacaagca gucccucacc gucggcaagg ucaccuccua caucaucaac     2580

aaccuccagc ccgacaccac cuaccgcauc cgcauccagg cccucaacuc ccucggcgcc     2640

ggccccuucu cccacaugau caagcucaag accaagcccc ucccccccga ccccccccgc     2700

cucgagugcg ucgccuucuc ccaccagaac cucaagcuca aguggggcga gggcaccccc     2760

aagacccucu ccaccgacuc cauccaguac caccuccaga uggaggacaa gaacggccgc     2820

uucgucuccc ucuaccgcgg ccccugccac accuacaagg uccagcgccu caacgagucc     2880

accuccuaca aguucugcau ccaggccugc aacgaggccg gcgagggccc ccucucccag     2940

gaguacaucu ucaccacccc caaguccguc cccgccgccc ucaaggcccc caagaucgag     3000

aaggucaacg accacaucug cgagaucacc ugggagugcc uccagcccau gaagggcgac     3060

cccgucaucu acucccucca ggucaugcuc ggcaaggacu ccgaguucaa gcagaucuac     3120

aagggccccg acuccuccuu ccgcuacucc ucccuccagc ucaacugcga guaccgcuuc     3180

cgcgucugcg ccauccgcca gugccaggac ucccucggcc accaggaccu cgucggcccc     3240

uacuccacca ccguccucuu caucucccag cgcaccgagc cccccgccuc caccaaccgc     3300

gacaccgucg aguccacccg cacccgccgc gcccucuccg acgagcagug cgccgccguc     3360

auccucgucc ucuucgccuu cuucuccauc cucaucgccu ucaucaucca guacuucguc     3420

aucaaguga                                                             3429


<210>  1592
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAX08809

<400>  1592
augagcggcc ccgcccaggu gccuaugaug uccccaaacg ggucuguccc gcccaucuac       60

guuccuccag gauaugcucc ccaagugauu gaggacaaug guguaagaag gguggucgug      120

guuccucagg caccagaguu ccaccccggc ucacauaccg ugcugcaccg gaguccucau      180

ccaccgcucc ccggguuuau accuguccca acaaugaugc ccccuccacc ccgccacaug      240

uacagcccgg ugacuggagc cggcgauaug acgacccagu auaugccuca guaccaaucc      300

ucucagguau auggugacgu ugaugcgcau ucgacacacg ggcgaucaaa cuuccgugac      360

gaaagaagca guaagacuua cgaaaggcuu cagaaaaagc ugaaagaucg gcagggaacc      420

caaaaggaca aaauguccuc ucccccaagc uccccucaga agugccccuc accaaucaau      480

gagcacaacg gcuugauuaa gggccagauc gcugggggaa uuaauacagg uagugccaaa      540

aucaagagcg gcaaagggaa gggaggcacc cagguggaua cugaaauaga ggagaaagac      600

gaagagacaa aggcauuuga agccuuacug ucuaacaucg ucaagcccgu ggcuuccgau      660

auucaagcac gcaccguggu ccuaacgugg ucaccuccaa gcagucucau caauggugag      720

acugacgagu cuuccguucc ggaacuguau ggguacgagg ugcuuauuag cucgaccgga      780

aaagauggca aguacaaauc uguauaugug ggcgaagaga caaacaucac ucugaaugac      840

uugaagcccg ccauggauua ccaugcuaaa guccaggccg aauauaacuc cauaaagggg      900

accccuucag aggcggagau uuucacaacc cucaguugug aaccagacau ccccaauccu      960

ccaagaauug caaacaggac gaaaaauagc cugacucugc aguggaaggc ccccuccgac     1020

aacggaucua agauccaaaa uuuugugcuc gagugggaug aagguaaagg caacggggag     1080

uucugccagu guuacauggg aagccagaag caguuuaaaa ucacaaaguu aucaccggcu     1140

augggcugca aauuccggcu gagugcccgc aacgacuaug guaccuccgg guuuagcgaa     1200

gagguucuuu acuauacuuc uggcugugca ccuucaaugc cagcuagucc cguguugaca     1260

aaggccggaa uuaccuggcu gagccuacaa ugguccaagc cuucuggcac gcccucggau     1320

gaggggauaa gcuacauccu cgaaauggag gaagagaccu ccggauacgg uuucaaacca     1380

aaguaugacg gcgaagaucu ggcguacaca gucaaaaauc uucgaagauc aacuaaguau     1440

aaauuuaagg ugauugccua caacagugag gggaagucua auccuagcga gguaguugag     1500

uucaccacau gccccgacaa accaggaauc ccggugaagc cuuccgucaa aggcaagaua     1560

cacucacaua gcuuuaaaau uacuugggau cccccaaagg acaacggugg ggcaaccauc     1620

aauaaguaug uggucgaaau ggcugaaggc ucuaacggaa auaaauggga gaugaucuac     1680

uccggcgcca caagggagca ccugugugau cgguugaacc ccgggugcuu cuaucgucuc     1740

cgcguguacu guauuaguga cggaggucag agcgcuguuu cugaaucccu guuagugcag     1800

accccugccg uaccacccgg cccuugccug ccgccaagac uccaggggag gcccaaggca     1860

aaagagaucc aacuucggug gggaccucca cuggucgaug gcgguucacc cauuaguugu     1920

uacagcgugg aaaugucgcc uauagagaag gacgaaccgc gagagguuua ucaggggucc     1980

gagguggaau gcacugucuc uagcuugcua cccggcaaaa cguacucauu ccgccugaga     2040

gccgcuaaua agaugggauu uggcccauuc agugagaaau gcgacaucac aaccgcgccu     2100

gggcccccag aucaguguaa gccuccccag gugacuugca gguccgcaac cugugcccaa     2160

guaaacuggg aagugccacu cucuaaugga acagacguua ccgaguaucg gcuggaaugg     2220

ggcggugucg aggggagcau gcagauuugc uacuguggac cgggccuuuc cuaugagauc     2280

aagggucuga gcccugcuac uacauacuau ugccgcgugc aggccuuguc aguggucggc     2340

gcagggcccu uuagugaagu uguggccugu gugacgccac ccucuguacc uggaaucgug     2400

accugccucc aggagauuuc cgaugacgaa auagagaacc cacacuacag ccccucgacu     2460

ugucuggcua ucucauggga aaaaccuugc gaucauggcu cugagauuuu agccuacagu     2520

aucgacuucg gggauaagca aucccugaca gucggaaaag uuaccagcua uauuaucaau     2580

aaccuacagc cggacacaac uuacagaaua aggauccagg cacucaauuc ucugggcgcg     2640

gguccauuua gccacaugau uaagcugaaa accaagcccu ugccucccga uccaccucgu     2700

cuggagugug uggcuuucuc ccaucaaaac cucaagcuga aauggggaga agggacgccc     2760

aagacccuuu caacagacag uauccaguau caccuucaga uggaggauaa aaacggccgg     2820

uuugucagcu uguaccgagg uccaugccau acuuauaagg ugcagagacu caaugaaucu     2880

accuccuaca aauucugcau ucaagccugu aacgaggcag gcgaggggcc ucugucacag     2940

gaauauaucu uuacaacucc gaagaguguu cccgccgcuu uaaaggcccc aaaaauagag     3000

aaggugaaug accacauuug cgaaaucacc ugggaguguc ugcagccuau gaaaggagau     3060

cccguaauuu acagccuaca ggucaugcuc ggcaaggacu ccgaguucaa acaaaucuac     3120

aaggggccag acucuucguu uagguauagc ucacugcagc uuaacugcga auaccgcuuc     3180

cgggugugug caauaagaca gugccaggau uccuugggac accaagaccu ggugggcccu     3240

uauaguacga caguccucuu uaucucucag aggaccgagc ccccggcuag cacuaaucgc     3300

gauacaguug aauccacccg aacucggcgu gcccugucag acgagcagug ugcggccgug     3360

auuuuaguac uguucgcuuu cuuuucuauc cuuauugcau ucaucauaca auacuuugug     3420

auuaaguga                                                             3429


<210>  1593
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAX08809

<400>  1593
augagcggcc ccgcccaggu gcccaugaug agccccaacg gcagcgugcc ccccaucuac       60

gugccccccg gcuacgcccc ccaggugauc gaggacaacg gcgugagaag agugguggug      120

gugccccagg cccccgaguu ccaccccggc agccacaccg ugcugcacag aagcccccac      180

cccccccugc ccggcuucau ccccgugccc accaugaugc cccccccccc cagacacaug      240

uacagccccg ugaccggcgc cggcgacaug accacccagu acaugcccca guaccagagc      300

agccaggugu acggcgacgu ggacgcccac agcacccacg gcagaagcaa cuucagagac      360

gagagaagca gcaagaccua cgagagacug cagaagaagc ugaaggacag acagggcacc      420

cagaaggaca agaugagcag cccccccagc agcccccaga agugccccag ccccaucaac      480

gagcacaacg gccugaucaa gggccagauc gccggcggca ucaacaccgg cagcgccaag      540

aucaagagcg gcaagggcaa gggcggcacc cagguggaca ccgagaucga ggagaaggac      600

gaggagacca aggccuucga ggcccugcug agcaacaucg ugaagcccgu ggccagcgac      660

auccaggcca gaaccguggu gcugaccugg agccccccca gcagccugau caacggcgag      720

accgacgaga gcagcgugcc cgagcuguac ggcuacgagg ugcugaucag cagcaccggc      780

aaggacggca aguacaagag cguguacgug ggcgaggaga ccaacaucac ccugaacgac      840

cugaagcccg ccauggacua ccacgccaag gugcaggccg aguacaacag caucaagggc      900

acccccagcg aggccgagau cuucaccacc cugagcugcg agcccgacau ccccaacccc      960

cccagaaucg ccaacagaac caagaacagc cugacccugc aguggaaggc ccccagcgac     1020

aacggcagca agauccagaa cuucgugcug gagugggacg agggcaaggg caacggcgag     1080

uucugccagu gcuacauggg cagccagaag caguucaaga ucaccaagcu gagccccgcc     1140

augggcugca aguucagacu gagcgccaga aacgacuacg gcaccagcgg cuucagcgag     1200

gaggugcugu acuacaccag cggcugcgcc cccagcaugc ccgccagccc cgugcugacc     1260

aaggccggca ucaccuggcu gagccugcag uggagcaagc ccagcggcac ccccagcgac     1320

gagggcauca gcuacauccu ggagauggag gaggagacca gcggcuacgg cuucaagccc     1380

aaguacgacg gcgaggaccu ggccuacacc gugaagaacc ugagaagaag caccaaguac     1440

aaguucaagg ugaucgccua caacagcgag ggcaagagca accccagcga ggugguggag     1500

uucaccaccu gccccgacaa gcccggcauc cccgugaagc ccagcgugaa gggcaagauc     1560

cacagccaca gcuucaagau caccugggac ccccccaagg acaacggcgg cgccaccauc     1620

aacaaguacg ugguggagau ggccgagggc agcaacggca acaaguggga gaugaucuac     1680

agcggcgcca ccagagagca ccugugcgac agacugaacc ccggcugcuu cuacagacug     1740

agaguguacu gcaucagcga cggcggccag agcgccguga gcgagagccu gcuggugcag     1800

acccccgccg ugccccccgg ccccugccug ccccccagac ugcagggcag acccaaggcc     1860

aaggagaucc agcugagaug gggccccccc cugguggacg gcggcagccc caucagcugc     1920

uacagcgugg agaugagccc caucgagaag gacgagccca gagaggugua ccagggcagc     1980

gagguggagu gcaccgugag cagccugcug cccggcaaga ccuacagcuu cagacugaga     2040

gccgccaaca agaugggcuu cggccccuuc agcgagaagu gcgacaucac caccgccccc     2100

ggcccccccg accagugcaa gcccccccag gugaccugca gaagcgccac cugcgcccag     2160

gugaacuggg aggugccccu gagcaacggc accgacguga ccgaguacag acuggagugg     2220

ggcggcgugg agggcagcau gcagaucugc uacugcggcc ccggccugag cuacgagauc     2280

aagggccuga gccccgccac caccuacuac ugcagagugc aggcccugag cguggugggc     2340

gccggccccu ucagcgaggu gguggccugc gugacccccc ccagcgugcc cggcaucgug     2400

accugccugc aggagaucag cgacgacgag aucgagaacc cccacuacag ccccagcacc     2460

ugccuggcca ucagcuggga gaagcccugc gaccacggca gcgagauccu ggccuacagc     2520

aucgacuucg gcgacaagca gagccugacc gugggcaagg ugaccagcua caucaucaac     2580

aaccugcagc ccgacaccac cuacagaauc agaauccagg cccugaacag ccugggcgcc     2640

ggccccuuca gccacaugau caagcugaag accaagcccc ugccccccga cccccccaga     2700

cuggagugcg uggccuucag ccaccagaac cugaagcuga aguggggcga gggcaccccc     2760

aagacccuga gcaccgacag cauccaguac caccugcaga uggaggacaa gaacggcaga     2820

uucgugagcc uguacagagg ccccugccac accuacaagg ugcagagacu gaacgagagc     2880

accagcuaca aguucugcau ccaggccugc aacgaggccg gcgagggccc ccugagccag     2940

gaguacaucu ucaccacccc caagagcgug cccgccgccc ugaaggcccc caagaucgag     3000

aaggugaacg accacaucug cgagaucacc ugggagugcc ugcagcccau gaagggcgac     3060

cccgugaucu acagccugca ggugaugcug ggcaaggaca gcgaguucaa gcagaucuac     3120

aagggccccg acagcagcuu cagauacagc agccugcagc ugaacugcga guacagauuc     3180

agagugugcg ccaucagaca gugccaggac agccugggcc accaggaccu ggugggcccc     3240

uacagcacca ccgugcuguu caucagccag agaaccgagc cccccgccag caccaacaga     3300

gacaccgugg agagcaccag aaccagaaga gcccugagcg acgagcagug cgccgccgug     3360

auccuggugc uguucgccuu cuucagcauc cugaucgccu ucaucaucca guacuucgug     3420

aucaaguga                                                             3429


<210>  1594
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAX08809

<400>  1594
augagcggcc ccgcccaggu gccuaugaug uccccgaacg ggucugugcc cccuaucuac       60

guucccccug gauaugcucc ccaagugauu gaggacaaug gcgugagacg ggucgugguu      120

gugccucagg ccccggaguu ccaccccggg agccauaccg uccugcaccg cuccccucau      180

cccccucucc ccggauuuau cccggugccu acaaugaugc ccccuccucc cagacacaug      240

uacucucccg uuacgggcgc gggggauaug accacacagu auaugccgca guaccaaagc      300

ucccaggugu auggagacgu cgaugcucau ucuacccacg gccggagcaa cuuccgcgac      360

gaaagaucca gcaagacaua cgaacggcug cagaaaaagc ucaaagaucg ccagggcacc      420

caaaaggaca aaaugucuuc cccucccagc ucuccccaga agugcccuuc ccccauuaau      480

gagcacaacg ggcugaucaa gggacagauu gccggcggga ucaauacagg aagcgccaaa      540

aucaagucug gcaaagggaa gggaggcacc cagguggaua cggaaauuga ggagaaagac      600

gaagagacca aggcuuuuga agcccuccug uccaacaucg ugaagccggu cgcuagcgau      660

auucaagcca gaacaguugu gcuuaccugg uccccucccu cuagccugau caauggcgag      720

acagacgagu ccagcgugcc ugaacucuau ggguacgagg uccugauuuc uuccaccgga      780

aaagauggca aguacaaaag cguguauguu ggggaagaga cgaacaucac acugaaugac      840

cucaagcccg cgauggauua ccaugccaaa gugcaggcug aauauaacuc uauuaaggga      900

accccuagcg aggccgagau cuucacaacc cuguccugug aacccgacau cccgaauccu      960

ccccggauug cuaaccgcac caaaaauucu cuuacacugc aguggaaggc ccccagcgac     1020

aacggcucca agauccaaaa uuuuguccuc gagugggaug aagggaaagg aaacggcgag     1080

uucugccagu guuacauggg cagccagaag caguuuaaaa uuacgaagcu gucuccugcg     1140

auggggugca aauucagacu uuccgcccgg aacgacuaug gaaccagcgg cuuuucugaa     1200

gaggugcugu acuauacauc cgggugugcu ccgagcaugc ccgccucccc uguucucacc     1260

aaggcuggaa ucacauggcu gucucugcaa uggagcaagc ccuccggcac cccuucugau     1320

gaggggauua gcuacauccu cgaaauggag gaagagacgu ccggcuacgg auucaaaccc     1380

aaguaugacg gcgaagaucu ggccuacaca gugaaaaauc uucgcagaag caccaaguau     1440

aaauuuaagg ucaucgccua caacucugag gggaagucca auccuagcga gguggucgag     1500

uucaccacau gccccgacaa accgggcauu ccugugaagc ccucuguuaa aggaaagauc     1560

cacucccaua gcuuuaaaau uaccugggau ccucccaagg acaacggggg agcuacaauc     1620

aauaaguaug uggucgaaau ggcggaaggc ucuaacggga auaaauggga gaugauuuac     1680

agcggcgcca cgcgggagca ccugugugau cgccucaacc cgggaugcuu cuauagacug     1740

cggguguacu guaucuccga cggcgggcag agcgcuguuu cugaaucccu ucuggugcag     1800

accccugccg ugcccccugg acccugccuu cccccuagac ugcagggccg cccgaaggcc     1860

aaagagaucc aacugcggug ggggcccccu cucgucgaug gaggcagccc cauuuccugu     1920

uacucugugg aaaugagccc uaucgagaag gacgaaccca gagagguuua ucaggggucc     1980

gaggucgaau gcacaguguc uagccugcuu ccuggcaaaa ccuacuccuu ccgccugcgg     2040

gcugccaaua agaugggauu uggcccguuc ucugagaaau gcgacauuac aaccgcgccc     2100

gggccucccg aucaguguaa gccuccccag gugacgugca gaagcgcuac cugugcccaa     2160

gucaacuggg aagugccgcu cuccaaugga acagacguua ccgaguaucg ccuggaaugg     2220

ggcggggugg agggaagcau gcagaucugc uacuguggcc cugggcuuuc uuaugagauu     2280

aagggccugu cccccgccac aaccuacuau ugccgggucc aggcucucag cgugguugga     2340

gccggccccu uuucugaagu ggucgcuugu gugacgccuc ccuccguucc ugggaucgug     2400

acaugccugc aggagauuag cgaugacgaa aucgagaacc cgcacuacuc ucccuccacc     2460

ugucuggcca ucagcuggga aaaaccuugc gaucauggau ccgagauucu cgcguacagc     2520

aucgacuucg gcgauaagca aucucugaca gucgggaaag ugaccagcua uauuaucaau     2580

aaccuucagc ccgacaccac auaccgcauu agaauccagg cccucaauuc ccugggagcu     2640

ggcccuuuuu cucacaugau caagcugaaa acgaagcccc ugccgccuga ucccccucgg     2700

cuugagugug uggccuucag ccaucaaaac cucaagcuga aauggggcga agggaccccc     2760

aagacacugu ccaccgacuc uauucaguau caccuccaga uggaggauaa aaacggaaga     2820

uuugucagcc uguaccgcgg cccuugccau acauauaagg uucagcggcu uaaugaaucc     2880

accucuuaca aauucugcau ccaggcuugu aacgaggccg gggagggacc ccugagccaa     2940

gaauauauuu uuacgacacc gaaguccgug ccugcggccc ucaaggcucc caaaaucgag     3000

aaggugaaug accacauuug cgaaaucacc ugggaguguc ugcagcccau gaaaggcgau     3060

ccugucaucu acagccuuca ggugaugcug gggaaggacu cugaguucaa acaaauuuac     3120

aagggaccgg acuccagcuu uagauauucu ucccuccagc ugaacugcga auaccgguuc     3180

cgcguuugug ccaucagaca gugccaggau agccugggcc accaagaccu cgugggcccc     3240

uauuccacca caguccuguu uauuucucag cggaccgagc cucccgcuag cacaaauaga     3300

gauacggugg aauccacccg cacacggaga gcccuuagcg acgagcagug ugccgcuguu     3360

auccuggucc ucuucgcguu cuuuucuauu cugaucgccu ucaucauuca auacuuuguc     3420

aucaaguga                                                             3429


<210>  1595
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A6NH44

<400>  1595

Met Pro Pro Ser Lys Pro His Pro Pro Val Val Gly Lys Val Thr His 
1               5                   10                  15      


His Ser Ile Glu Leu Tyr Trp Asp Leu Glu Lys Lys Ala Lys Arg Gln 
            20                  25                  30          


Gly Pro Gln Glu Gln Trp Phe Arg Phe Ser Ile Glu Glu Glu Asp Pro 
        35                  40                  45              


Lys Met His Thr Tyr Gly Ile Ile Tyr Thr Gly Tyr Ala Thr Lys His 
    50                  55                  60                  


Val Val Glu Gly Leu Glu Pro Arg Thr Leu Tyr Arg Phe Arg Leu Lys 
65                  70                  75                  80  


Val Thr Ser Pro Ser Gly Glu Cys Glu Tyr Ser Pro Leu Val Ser Val 
                85                  90                  95      


Ser Thr Thr Arg Glu Pro Ile Ser Ser Glu His Leu His Arg Ala Val 
            100                 105                 110         


Ser Val Asn Asp Glu Asp Leu Leu Val Arg Ile Leu Gln Gly Gly Arg 
        115                 120                 125             


Val Lys Val Asp Val Pro Asn Lys Phe Gly Phe Thr Ala Leu Met Val 
    130                 135                 140                 


Ala Ala Gln Lys Gly Tyr Thr Arg Leu Val Lys Ile Leu Val Ser Asn 
145                 150                 155                 160 


Gly Thr Asp Val Asn Leu Lys Asn Gly Ser Gly Lys Asp Ser Leu Met 
                165                 170                 175     


Leu Ala Cys Tyr Ala Gly His Leu Asp Val Val Lys Tyr Leu Arg Arg 
            180                 185                 190         


His Gly Ala Ser Trp Gln Ala Arg Asp Leu Gly Gly Cys Thr Ala Leu 
        195                 200                 205             


His Trp Ala Ala Asp Gly Gly His Cys Ser Val Ile Glu Trp Met Ile 
    210                 215                 220                 


Lys Asp Gly Cys Glu Val Asp Val Val Asp Thr Gly Ser Gly Trp Thr 
225                 230                 235                 240 


Pro Leu Met Arg Val Ser Ala Val Ser Gly Asn Gln Arg Val Ala Ser 
                245                 250                 255     


Leu Leu Ile Asp Ala Gly Ala Asn Val Asn Val Lys Asp Arg Asn Gly 
            260                 265                 270         


Lys Thr Pro Leu Met Val Ala Val Leu Asn Asn His Glu Glu Leu Val 
        275                 280                 285             


Gln Leu Leu Leu Asp Lys Gly Ala Asp Ala Ser Val Lys Asn Glu Phe 
    290                 295                 300                 


Gly Lys Gly Val Leu Glu Met Ala Arg Val Phe Asp Arg Gln Ser Val 
305                 310                 315                 320 


Val Ser Leu Leu Glu Glu Arg Lys Lys Lys Gln Arg Pro Lys Lys Ser 
                325                 330                 335     


Cys Val Cys 
            


<210>  1596
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAW49214

<400>  1596
augccacccu caaagccuca uccaccuguc gugggcaaag ugacucauca cagcauugaa       60

uuauacuggg aucuggaaaa gaaagccaaa cgccaaggac cucaagagca gugguucagg      120

uucucgauug aagaagaaga ccccaaaaug cacacuuaug guaucauuua uacgggauau      180

gcaacgaagc auguuguuga aggucuggaa ccaaggacgc uguacagauu ucgccugaag      240

gucaccagcc ccucugggga gugugaguac agcccacucg ucucaguguc uacaaccaga      300

gagcccauaa guagugagca cuugcaccgg gcugucagug ugaaugauga agauuugcug      360

guccgaauac uucaaggagg ccguguuaag guugauguuc ccaauaaguu uggcuuuacc      420

gcucugaugg uugcugccca gaaaggauac accaggcuug ugaaaauccu aguuucuaau      480

ggcacagacg ugaaucugaa gaauggaagu ggcaaggaca gucuaaugcu ggcgugcuau      540

gcgggacacc uagauguugu gaaauaucuc cgaagacaug gcgcuucuug gcaggcuaga      600

gaccugggag gcuguacagc ucugcacugg gcugcagaug gaggccacug cagugugauu      660

gaguggauga uaaaggaugg cugugaggua gacgucgugg acacugguuc aggauggacc      720

ccacucauga gagucucugc ggugucggga aaucagaggg uggccucucu ucuaauugau      780

gcuggggcca augugaaugu gaaggacaga aauggaaaga cgccccuuau gguggcugug      840

uuaaauaauc augaagaguu aguucaguua cuucuugaca aaggggcaga ugcaagugua      900

aaaaaugagu ucggcaaagg uguccuagaa auggccagag uuuuugacag acagagugua      960

gucuccuuau uagaagaaag gaaaaaaaag cagaggccaa agaagucuug ugucugcuga     1020


<210>  1597
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAW49214

<400>  1597
augcccccga gcaagcccca cccgcccgug gucggcaagg ugacccacca cagcaucgag       60

cuguacuggg accucgagaa gaaggccaag cgccaggggc cccaggagca gugguuccgg      120

uucagcaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua cacgggguac      180

gccaccaagc acguggucga gggccuggag ccccgcaccc uguaccgguu ccgccucaag      240

gugaccuccc ccagcgggga gugcgaguac uccccgcugg ugagcgucuc cacgacccgg      300

gagcccauca gcuccgagca ccuccaccgc gcggugagcg ugaacgacga ggaccugcug      360

guccggaucc ugcagggcgg ccgcgugaag guggacgucc ccaacaaguu cggguucacc      420

gcccucaugg uggccgccca gaagggcuac acccggcugg ugaagauccu ggucuccaac      480

gggacggacg ugaaccucaa gaacggcagc gggaaggacu cccugaugcu ggccugcuac      540

gcgggccacc ucgacguggu caaguaccug cgccggcacg gcgccagcug gcaggcccgc      600

gaccucgggg gcugcaccgc ccugcacugg gcggccgacg ggggccacug cuccgugauc      660

gaguggauga ucaaggacgg cugcgaggug gacgucgugg acaccgggag cggcuggacg      720

ccccugaugc ggguguccgc cgucagcggg aaccagcgcg uggccucccu gcucaucgac      780

gccggcgcga acgucaacgu gaaggaccgg aacgggaaga ccccgcugau gguggccguc      840

cugaacaacc acgaggagcu cgugcagcug cugcucgaca agggcgccga cgccagcgug      900

aagaacgagu ucggcaaggg gguccuggag auggcccgcg uguucgaccg gcagagcgug      960

gucucccugc ucgaggagcg caagaagaag cagcggccca agaaguccug cgugugcuga     1020


<210>  1598
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAW49214

<400>  1598
augccccccu ccaagcccca cccccccguc gucggcaagg ucacccacca cuccaucgag       60

cucuacuggg accucgagaa gaaggccaag cgccagggcc cccaggagca gugguuccgc      120

uucuccaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua caccggcuac      180

gccaccaagc acgucgucga gggccucgag ccccgcaccc ucuaccgcuu ccgccucaag      240

gucaccuccc ccuccggcga gugcgaguac uccccccucg ucuccgucuc caccacccgc      300

gagcccaucu ccuccgagca ccuccaccgc gccgucuccg ucaacgacga ggaccuccuc      360

guccgcaucc uccagggcgg ccgcgucaag gucgacgucc ccaacaaguu cggcuucacc      420

gcccucaugg ucgccgccca gaagggcuac acccgccucg ucaagauccu cgucuccaac      480

ggcaccgacg ucaaccucaa gaacggcucc ggcaaggacu cccucaugcu cgccugcuac      540

gccggccacc ucgacgucgu caaguaccuc cgccgccacg gcgccuccug gcaggcccgc      600

gaccucggcg gcugcaccgc ccuccacugg gccgccgacg gcggccacug cuccgucauc      660

gaguggauga ucaaggacgg cugcgagguc gacgucgucg acaccggcuc cggcuggacc      720

ccccucaugc gcgucuccgc cgucuccggc aaccagcgcg ucgccucccu ccucaucgac      780

gccggcgcca acgucaacgu caaggaccgc aacggcaaga ccccccucau ggucgccguc      840

cucaacaacc acgaggagcu cguccagcuc cuccucgaca agggcgccga cgccuccguc      900

aagaacgagu ucggcaaggg cguccucgag auggcccgcg ucuucgaccg ccaguccguc      960

gucucccucc ucgaggagcg caagaagaag cagcgcccca agaaguccug cgucugcuga     1020


<210>  1599
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAW49214

<400>  1599
augcccccua gcaagccaca cccgcccgug gucggcaaag uuacccauca cuccaucgag       60

cuguacuggg accucgaaaa gaaagccaag agacaggggc cucaagagca gugguucagg      120

uuuucuauug aagaggaaga uccaaaaaug cauacauaug gaauaaucua cacugguuau      180

gcuacgaagc acgugguaga gggccuugag ccccggaccc uguaccgcuu ccgauugaag      240

gugacaucac cuagugggga augcgaguau agcccauuag ucuccguguc uacuacccgu      300

gaacccauuu cgucagagca ucugcacaga gcaguuagcg ugaacgacga ggaucuacuc      360

gucaggaucc ugcagggagg ccgggugaaa guagacguuc cuaauaaguu ugguuucaca      420

gcccuuaugg uggcggcuca gaaaggguac acccgccugg ucaagauuuu ggugaguaac      480

ggaacugaug ugaaucucaa aaacggcucc ggcaaggacu cucugaugcu ggccuguuau      540

gcagggcacc ucgaugucgu uaaguacuua agaaggcaug gagccagcug gcaagcucgg      600

gaccugggug gcugcacagc acuucacugg gccgcugaug ggggacauug uuccgugauc      660

gaauggauga uaaaagacgg cugcgaggua gauguggucg acaccgguuc aggguggacg      720

ccauugaugc gcgugagugc cguuagcgga aaucagcgag uggcgucucu gcuaaucgau      780

gcaggcgcca acgucaaugu gaaggacaga aacggcaaaa cuccgcucau gguagcuguu      840

cugaauaacc acgaggaacu ugugcagcug uugcucgaca agggggccga ugcauccguc      900

aaaaaugaau uuggaaaggg ugugcuggag auggcuaggg ucuucgaccg gcagucagug      960

guuagcuuac uggaggaacg uaaaaagaag caacgcccca aaaagaguug ugugugcuga     1020


<210>  1600
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAW49214

<400>  1600
augcccccca gcaagcccca cccccccgug gugggcaagg ugacccacca cagcaucgag       60

cuguacuggg accuggagaa gaaggccaag agacagggcc cccaggagca gugguucaga      120

uucagcaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua caccggcuac      180

gccaccaagc acguggugga gggccuggag cccagaaccc uguacagauu cagacugaag      240

gugaccagcc ccagcggcga gugcgaguac agcccccugg ugagcgugag caccaccaga      300

gagcccauca gcagcgagca ccugcacaga gccgugagcg ugaacgacga ggaccugcug      360

gugagaaucc ugcagggcgg cagagugaag guggacgugc ccaacaaguu cggcuucacc      420

gcccugaugg uggccgccca gaagggcuac accagacugg ugaagauccu ggugagcaac      480

ggcaccgacg ugaaccugaa gaacggcagc ggcaaggaca gccugaugcu ggccugcuac      540

gccggccacc uggacguggu gaaguaccug agaagacacg gcgccagcug gcaggccaga      600

gaccugggcg gcugcaccgc ccugcacugg gccgccgacg gcggccacug cagcgugauc      660

gaguggauga ucaaggacgg cugcgaggug gacguggugg acaccggcag cggcuggacc      720

ccccugauga gagugagcgc cgugagcggc aaccagagag uggccagccu gcugaucgac      780

gccggcgcca acgugaacgu gaaggacaga aacggcaaga ccccccugau gguggccgug      840

cugaacaacc acgaggagcu ggugcagcug cugcuggaca agggcgccga cgccagcgug      900

aagaacgagu ucggcaaggg cgugcuggag auggccagag uguucgacag acagagcgug      960

gugagccugc uggaggagag aaagaagaag cagagaccca agaagagcug cgugugcuga     1020


<210>  1601
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAW49214

<400>  1601
augcccccua gcaagccgca ucccccugug gucggcaaag uuacccacca cuccaucgag       60

cuguacuggg accucgaaaa gaaagccaag agacaggggc cccaagagca gugguuccgg      120

uuuucuauug aagaggaaga uccuaaaaug cauacauaug gaaucauuua cacgggcuau      180

gcuaccaagc acguggugga ggggcuggag ccccgcacac uuuacagauu ccggcugaag      240

gucaccagcc cuuccggaga augcgaguau ucuccgcucg ugagcguuuc cacaacccgc      300

gaacccaucu cuagcgagca ucugcacaga gccguguccg ucaacgacga ggaucuucug      360

gugcggauuc uccagggcgg gcgcguuaaa guggacgucc cuaauaaguu uggauucaca      420

gcgcugaugg uggcugccca gaaaggcuac accagacugg ugaagauccu cgucagcaac      480

ggcacggaug uuaaucugaa aaacgggucu ggaaaggacu cccuuaugcu ggccuguuau      540

gcuggccacc ucgauguggu gaaguaccug cggcgccaug gggccagcug gcaagcuaga      600

gaccuuggag gcugcaccgc ccugcacugg gcggccgaug ggggacauug uucugucauc      660

gaauggauga uuaaagacgg cugcgaggug gauguugugg acacaggcuc cggguggaca      720

ccccucaugc gggucagcgc ugugucugga aaucagcgcg uugccucccu gcugaucgau      780

gcuggcgcca acgugaaugu caaggacaga aacgggaaaa ccccucucau gguggcgguc      840

cugaauaacc acgaggaacu ugugcagcug cuccuggaca agggagccga ugcuagcguu      900

aaaaaugaau uuggcaaggg ggugcuugag auggcccggg ucuucgaccg ccaguccgug      960

guuucucugc ucgaggaacg gaaaaagaag caaagaccca aaaagagcug ugugugcuga     1020


<210>  1602
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__A8K6A5

<400>  1602

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Ala Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Ser Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Gly Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Glu Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp Ile Ile Ile Leu Ala Ile Leu Phe 
        995                 1000                1005            


Gly Leu Leu Leu Leu Gly Leu Leu Ile Tyr Ile Leu Tyr Lys Leu Gly 
    1010                1015                1020                


Phe Phe Lys Arg Ser Leu Pro Tyr Gly Thr Ala Met Glu Lys Ala Gln 
1025                1030                1035                1040


Leu Lys Pro Pro Ala Thr Ser Asp Ala 
                1045                


<210>  1603
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAF84259

<400>  1603
auggggagcc ggacgccaga guccccucuc cacgccgugc agcugcgcug gggcccccgg       60

cgccgacccc cgcugcugcc gcugcuguug cugcugcugc cgccgccacc cagggucggg      120

ggcuucaacu uagacgcgga ggccccagca guacucucgg ggcccccggg cuccuucuuc      180

ggauucucag uggaguuuua ccggccggga acagacgggg ucagugugcu ggugggagca      240

cccaaggcua auaccagcca gccaggagug cugcagggug gugcugucua ccucuguccu      300

uggggugcca gccccacuca gugcaccccc auugaauuug acagcaaagg cucucggcuc      360

cuggaguccu cacuguccag cucagaggga gaggagccug uggaguacaa guccuugcag      420

ugguucgggg caacaguucg agcccauggc uccuccaucu uggcaugcgc uccacuguac      480

agcuggcgca cagagaagga gccacugagc gaccccgugg gcaccugcua ccucuccaca      540

gauaacuuca cccgaauucu ggaguaugca cccugccgcu cagauuucag cugggcagca      600

ggacaggguu acugccaagg aggcuucagu gccgaguuca ccaagacugg ccgugugguu      660

uuagguggac caggaagcua uuucuggcaa ggccagaucc ugucugccac ucaggagcag      720

auugcagaau cuuauuaccc cgaguaccug aucaaccugg uucaggggca gcugcagacu      780

cgccaggcca guuccaucua ugaugacagc uaccuaggau acucuguggc uguuggugaa      840

uucaguggug augacacaga agacuuuguu gcuggugugc ccaaagggaa ccucacuuac      900

ggcuauguca ccauccuuaa uggcucagac auucgauccc ucuacaacuu cucaggggaa      960

cagauggccu ccuacuuugc cuaugcagug gccgccacag acgucaaugg ggacgggcug     1020

gaugacuugc uggugggggc accccugcuc auggaucgga ccccugacgg gcggccucag     1080

gaggugggca gggucuacgu cuaccugcag cacccagccg gcauagaguc cacgcccacc     1140

cuuacccuca cuggccauga ugaguuuggc cgauuuggca gcuccuugac cccccugggg     1200

gaccuggacc aggauggcua caaugaugug gccaucgggg cucccuuugg uggggagacc     1260

cagcagggag uaguguuugu auuuccuggg ggcccaggag ggcugggcuc uaagccuucc     1320

cagguucugc agccccugug ggcagccagc cacaccccag acuucuuugg cucugcccuu     1380

cgaggaggcc gagaccugga uggcaaugga uauccugauc ugauuguggg guccuuuggu     1440

guggacaagg cugugguaua caggggccgc cccaucgugu ccgcuagugc cucccucacc     1500

aucuuccccg ccauguucaa cccagaggag cggagcugca gcuuagaggg gaacccugug     1560

gccugcauca accuuagcuu cugccucaau gcuucuggaa aacacguugc ugacuccauu     1620

gguuucacag uggaacuuca gcuggacugg cagaagcaga agggaggggu acggcgggca     1680

cuguuccugg ccuccaggca ggcaacccug acccagaccc ugcucaucca gaauggggcu     1740

cgagaggauu gcagagagau gaagaucuac cucaggaacg agucagaauu ucgagacaaa     1800

cucucgccga uucacaucgc ucucaacuuc uccuuggacc cccaagcccc aguggacagc     1860

cacggccuca ggccagcccu acauuaucag agcaagagcc ggauagagga caaggcucag     1920

aucuugcugg gcuguggaga agacaacauc ugugugccug accugcagcu ggaaguguuu     1980

ggggagcaga accaugugua ccugggugac aagaaugccc ugaaccucac uuuccaugcc     2040

cagaaugugg gugagggugg cgccuaugag gcugagcuuc gggucaccgc cccuccagag     2100

gcugaguacu caggacucgu cagacaccca gggaacuucu ccagccugag cugugacuac     2160

uuugccguga accagagccg ccugcuggug ugugaccugg gcaaccccau gaaggcagga     2220

gccagucugu gggguggccu ucgguuuaca gucccucauc uccgggacac uaagaaaacc     2280

auccaguuug acuuccagau ccucagcaag aaucucaaca acucgcaaag cgacgugguu     2340

uccuuucggc ucuccgugga ggcucaggcc caggucaccc ugaacggugu cuccaagccu     2400

gaggcagugc uauucccagu aagcgacugg cauccccgag accagccuca ggaggaggag     2460

gaccugggac cugcugucca ccaugucuau gagcucauca accaaggccc cagcuccauu     2520

agccagggug ugcuggaacu cagcuguccc caggcucugg aaggucagca gcuccuauau     2580

gugaccagag uuacgggacu caacugcacc accaaucacc ccauuaaccc aaagggccug     2640

gaguuggauc ccgaggguuc ccugcaccac cagcaaaaac gggaagcucc aagccgcagc     2700

ucugcuuccu cgggaccuca gauccugaaa ugcccggagg cugaguguuu caggcugcgc     2760

ugugagcucg ggccccugca ccaacaagag agccaaaguc ugcaguugca uuuccgaguc     2820

ugggccaaga cuuucuugca gcgggagcac cagccauuua gccugcagug ugaggcugug     2880

uacaaagccc ugaagaugcc cuaccgaauc cugccucggc agcugcccca aaaagagcgu     2940

cagguggcca cagcugugca auggaccaag gcagaaggca gcuauggcgu cccacugugg     3000

aucaucaucc uagccauccu guuuggccuc cugcuccuag gucuacucau cuacauccuc     3060

uacaagcuug gauucuucaa acgcucccuc ccauauggca ccgccaugga aaaagcucag     3120

cucaagccuc cagccaccuc ugaugccuga                                      3150


<210>  1604
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAF84259

<400>  1604
augggcagcc gcacccccga guccccgcug cacgccgugc agcuccggug ggggccccgc       60

cggcgccccc cccugcugcc gcuccugcug cuccugcugc cccccccccc gcgggucggc      120

ggguucaacc ucgacgccga ggcgcccgcc gugcugagcg gcccccccgg guccuucuuc      180

ggcuucagcg uggaguucua ccgcccgggc accgacgggg ucuccgugcu ggugggcgcc      240

cccaaggcca acacgagcca gcccgggguc cuccagggcg gggccgugua ccugugcccc      300

uggggcgcgu ccccgaccca gugcaccccc aucgaguucg acagcaaggg cucccggcug      360

cucgagagcu cccugagcuc cagcgagggg gaggagcccg uggaguacaa gucccugcag      420

ugguucggcg ccaccguccg cgcccacggg agcuccaucc ucgccugcgc gccccuguac      480

agcuggcgga cggagaagga gccgcugucc gaccccgugg gcaccugcua ccucagcacc      540

gacaacuuca cccgcauccu ggaguacgcc cccugccgga gcgacuucuc cugggccgcc      600

ggccaggggu acugccaggg cggguucagc gccgaguuca cgaagaccgg ccgcgugguc      660

cuggggggcc ccggcuccua cuucuggcag gggcagaucc ucagcgcgac ccaggagcag      720

aucgccgagu ccuacuaccc ggaguaccug aucaaccugg ugcagggcca gcuccagacc      780

cggcaggcca gcuccaucua cgacgacagc uaccuggggu acuccguggc cgucggcgag      840

uucagcgggg acgacacgga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggguacguca ccauccucaa cggcuccgac auccgcagcc uguacaacuu cuccggggag      960

cagauggcga gcuacuucgc cuacgccgug gccgccaccg acgugaacgg cgacgggcug     1020

gacgaccucc uggucggcgc gccccugcuc auggaccgga cgcccgacgg ccgcccgcag     1080

gagguggggc ggguguacgu cuaccugcag caccccgccg gcaucgaguc cacccccacc     1140

cugacccuca cggggcacga cgaguucggc cgcuucggca gcucccugac cccgcugggg     1200

gaccucgacc aggacggcua caacgacgug gccaucgggg cccccuucgg cggggagacc     1260

cagcagggcg ucguguucgu guuccccggc gggcccggcg ggcugggcag caagccgucc     1320

cagguccugc agccccucug ggccgcgagc cacacccccg acuucuucgg gagcgcccug     1380

cggggcggcc gcgaccugga cgggaacggc uaccccgacc ucaucguggg guccuucggc     1440

guggacaagg ccgucgugua ccgggggcgc ccgaucguga gcgccuccgc gagccugacg     1500

aucuuccccg ccauguucaa ccccgaggag cgcuccugca gccuggaggg caaccccguc     1560

gccugcauca accuguccuu cugccucaac gccagcggca agcacguggc cgacuccauc     1620

ggguucaccg uggagcugca gcuggacugg cagaagcaga agggcggggu ccggcgcgcg     1680

cucuuccugg ccagccggca ggccacccug acccagacgc uccugaucca gaacggcgcc     1740

cgcgaggacu gccgggagau gaagaucuac cugcgcaacg aguccgaguu ccgggacaag     1800

cucagcccga uccacaucgc ccugaacuuc ucccuggacc cccaggcgcc cguggacagc     1860

cacgggcucc gccccgcccu gcacuaccag uccaagagcc ggaucgagga caaggcccag     1920

auccugcucg gcugcggcga ggacaacauc ugcgugccgg accugcagcu ggaggucuuc     1980

ggggagcaga accacgugua ccucggcgac aagaacgccc ugaaccugac cuuccacgcc     2040

cagaacgugg gggagggcgg cgcguacgag gccgagcucc gcgucaccgc cccccccgag     2100

gccgaguacu ccgggcuggu gcggcacccc ggcaacuuca gcagccuguc cugcgacuac     2160

uucgcgguga accagagccg ccuccugguc ugcgaccugg ggaacccgau gaaggccggc     2220

gccucccucu gggggggccu gcgguucacc gugccccacc ugcgcgacac gaagaagacc     2280

auccaguucg acuuccagau ccucagcaag aaccugaaca acucccagag cgacgugguc     2340

uccuuccggc ugagcgugga ggcccaggcc caggugaccc ucaacggcgu cuccaagccc     2400

gaggcggugc uguuccccgu gagcgacugg cacccgcgcg accagcccca ggaggaggag     2460

gaccuggggc ccgccgucca ccacguguac gagcucauca accagggccc guccagcauc     2520

ucccaggggg ugcuggagcu gagcugcccc caggcccucg agggccagca gcugcuguac     2580

gucacccggg ugacggggcu caacugcacc accaaccacc ccaucaaccc caagggccug     2640

gagcuggacc cggagggcuc ccuccaccac cagcagaagc gcgaggcccc cagccggucc     2700

agcgccucca gcgggcccca gauccugaag ugccccgagg cggagugcuu ccgccugcgc     2760

ugcgagcucg gcccgcugca ccagcaggag agccaguccc ugcagcucca cuuccgggug     2820

ugggccaaga ccuuccugca gcgcgagcac cagcccuuca gccugcagug cgaggccguc     2880

uacaaggccc ucaagaugcc cuaccggauc cugccccgcc agcugccgca gaaggagcgg     2940

cagguggcca ccgcggugca guggacgaag gccgaggggu ccuacggcgu cccccucugg     3000

aucaucaucc uggccauccu guucgggcuc cugcugcucg gccugcugau cuacauccuc     3060

uacaagcugg gcuucuucaa gcgcagccug cccuacggga ccgccaugga gaaggcgcag     3120

cucaagcccc cggccaccuc cgacgccuga                                      3150


<210>  1605
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAF84259

<400>  1605
augggcuccc gcacccccga guccccccuc cacgccgucc agcuccgcug gggcccccgc       60

cgccgccccc cccuccuccc ccuccuccuc cuccuccucc cccccccccc ccgcgucggc      120

ggcuucaacc ucgacgccga ggcccccgcc guccucuccg gcccccccgg cuccuucuuc      180

ggcuucuccg ucgaguucua ccgccccggc accgacggcg ucuccguccu cgucggcgcc      240

cccaaggcca acaccuccca gcccggcguc cuccagggcg gcgccgucua ccucugcccc      300

uggggcgccu cccccaccca gugcaccccc aucgaguucg acuccaaggg cucccgccuc      360

cucgaguccu cccucuccuc cuccgagggc gaggagcccg ucgaguacaa gucccuccag      420

ugguucggcg ccaccguccg cgcccacggc uccuccaucc ucgccugcgc cccccucuac      480

uccuggcgca ccgagaagga gccccucucc gaccccgucg gcaccugcua ccucuccacc      540

gacaacuuca cccgcauccu cgaguacgcc cccugccgcu ccgacuucuc cugggccgcc      600

ggccagggcu acugccaggg cggcuucucc gccgaguuca ccaagaccgg ccgcgucguc      660

cucggcggcc ccggcuccua cuucuggcag ggccagaucc ucuccgccac ccaggagcag      720

aucgccgagu ccuacuaccc cgaguaccuc aucaaccucg uccagggcca gcuccagacc      780

cgccaggccu ccuccaucua cgacgacucc uaccucggcu acuccgucgc cgucggcgag      840

uucuccggcg acgacaccga ggacuucguc gccggcgucc ccaagggcaa ccucaccuac      900

ggcuacguca ccauccucaa cggcuccgac auccgcuccc ucuacaacuu cuccggcgag      960

cagauggccu ccuacuucgc cuacgccguc gccgccaccg acgucaacgg cgacggccuc     1020

gacgaccucc ucgucggcgc cccccuccuc auggaccgca cccccgacgg ccgcccccag     1080

gaggucggcc gcgucuacgu cuaccuccag caccccgccg gcaucgaguc cacccccacc     1140

cucacccuca ccggccacga cgaguucggc cgcuucggcu ccucccucac cccccucggc     1200

gaccucgacc aggacggcua caacgacguc gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ucgucuucgu cuuccccggc ggccccggcg gccucggcuc caagcccucc     1320

cagguccucc agccccucug ggccgccucc cacacccccg acuucuucgg cuccgcccuc     1380

cgcggcggcc gcgaccucga cggcaacggc uaccccgacc ucaucgucgg cuccuucggc     1440

gucgacaagg ccgucgucua ccgcggccgc cccaucgucu ccgccuccgc cucccucacc     1500

aucuuccccg ccauguucaa ccccgaggag cgcuccugcu cccucgaggg caaccccguc     1560

gccugcauca accucuccuu cugccucaac gccuccggca agcacgucgc cgacuccauc     1620

ggcuucaccg ucgagcucca gcucgacugg cagaagcaga agggcggcgu ccgccgcgcc     1680

cucuuccucg ccucccgcca ggccacccuc acccagaccc uccucaucca gaacggcgcc     1740

cgcgaggacu gccgcgagau gaagaucuac cuccgcaacg aguccgaguu ccgcgacaag     1800

cucuccccca uccacaucgc ccucaacuuc ucccucgacc cccaggcccc cgucgacucc     1860

cacggccucc gccccgcccu ccacuaccag uccaaguccc gcaucgagga caaggcccag     1920

auccuccucg gcugcggcga ggacaacauc ugcguccccg accuccagcu cgaggucuuc     1980

ggcgagcaga accacgucua ccucggcgac aagaacgccc ucaaccucac cuuccacgcc     2040

cagaacgucg gcgagggcgg cgccuacgag gccgagcucc gcgucaccgc cccccccgag     2100

gccgaguacu ccggccucgu ccgccacccc ggcaacuucu ccucccucuc cugcgacuac     2160

uucgccguca accagucccg ccuccucguc ugcgaccucg gcaaccccau gaaggccggc     2220

gccucccucu ggggcggccu ccgcuucacc gucccccacc uccgcgacac caagaagacc     2280

auccaguucg acuuccagau ccucuccaag aaccucaaca acucccaguc cgacgucguc     2340

uccuuccgcc ucuccgucga ggcccaggcc caggucaccc ucaacggcgu cuccaagccc     2400

gaggccgucc ucuuccccgu cuccgacugg cacccccgcg accagcccca ggaggaggag     2460

gaccucggcc ccgccgucca ccacgucuac gagcucauca accagggccc cuccuccauc     2520

ucccagggcg uccucgagcu cuccugcccc caggcccucg agggccagca gcuccucuac     2580

gucacccgcg ucaccggccu caacugcacc accaaccacc ccaucaaccc caagggccuc     2640

gagcucgacc ccgagggcuc ccuccaccac cagcagaagc gcgaggcccc cucccgcucc     2700

uccgccuccu ccggccccca gauccucaag ugccccgagg ccgagugcuu ccgccuccgc     2760

ugcgagcucg gcccccucca ccagcaggag ucccaguccc uccagcucca cuuccgcguc     2820

ugggccaaga ccuuccucca gcgcgagcac cagcccuucu cccuccagug cgaggccguc     2880

uacaaggccc ucaagaugcc cuaccgcauc cucccccgcc agcuccccca gaaggagcgc     2940

caggucgcca ccgccgucca guggaccaag gccgagggcu ccuacggcgu cccccucugg     3000

aucaucaucc ucgccauccu cuucggccuc cuccuccucg gccuccucau cuacauccuc     3060

uacaagcucg gcuucuucaa gcgcucccuc cccuacggca ccgccaugga gaaggcccag     3120

cucaagcccc ccgccaccuc cgacgccuga                                      3150


<210>  1606
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAF84259

<400>  1606
augggcagca gaacccccga guccccucug cacgccgugc agcucaggug ggggccacgg       60

cgccgaccgc cccuucugcc uuuguuacug cuacuccugc cacccccucc acgugucgga      120

gguuucaacc uugacgcuga agcacccgcc guucugucug gcccuccagg gucauuuuuc      180

ggauuuagug uggaguucua cagaccgggc acagauggug uaagcguguu ggucggggcg      240

cccaaggcua auacuuccca accuggagug cuccagggcg gcgccguuua ucugugccca      300

uggggagcau cucccacgca guguaccccu aucgaauuug acucgaaagg aucaaggcug      360

cucgagagca guuuauccuc uagcgaaggu gaggagccag uggaauacaa gucccugcag      420

ugguucggcg ccacaguccg ggcucauggg ucaaguauuc uugcaugcgc ccccuuguau      480

agcuggcgca cugagaaaga accgcugucu gauccugugg gaaccuguua ccuauccaca      540

gacaacuuua ccagaauacu cgaguaugcu cccugcaggu cagauuucag cugggccgcg      600

ggccaagguu acugucaagg gggauuuagu gcagaguuca cuaagacagg ccggguaguu      660

cugggcgggc caggaucuua uuuuuggcag ggucagaucc uuuccgccac ccaggaacag      720

auugcugaga gcuacuaccc ugaauaucug aucaauuugg ugcagggcca gcuccaaacg      780

cgccaggccu cgucuauuua cgacgauucc uaucuggggu acucagucgc agugggagag      840

uucaguggcg acgauacuga agacuuugug gcuggugucc ccaaagggaa cuuaaccuau      900

ggcuacguua caauccugaa uggaagcgau auacgauccc ucuauaacuu cucuggcgag      960

cagauggcca gcuacuucgc guacgccgug gcagcuacug acguaaaugg ggauggacuu     1020

gacgaccugu uggugggugc cccacuacug auggauagaa cccccgacgg caggccucaa     1080

gaggucgggc ggguguaugu uuaccuccag cacccagcug gaaucgaauc aacaccgacc     1140

cugacgcuua cuggccauga ugaguuuggu cguuucggga guucccugac acccuugggc     1200

gaccucgauc aggacggaua uaacgaugug gccauuggcg caccuuuugg gggagaaacc     1260

cagcaaggug ucguguucgu auuuccaggc gggcccggag gccuggguag caagccuucu     1320

cagguuuuac agccacugug ggccgcuuca cacacucccg acuucuuugg gagugcgcua     1380

cgcggcggaa gagaucucga cggcaauggg uacccggauc ugaucguggg gagcuucggc     1440

gucgacaagg caguggucua uaggggucgg ccuauugugu ccgccucugc uucgcuuaca     1500

aucuuuccag ccauguucaa ccccgaggaa cgaagcugcu ccuuggaggg gaauccuguu     1560

gcauguauaa accugucauu uugccucaau gccaguggaa aacauguggc ugacucuauu     1620

ggcuucaccg uagagcugca gcuugauugg caaaagcaga aagguggcgu ccgcagagcc     1680

cuguuuuugg caagcaggca ggcgacgcuc acccagacac uguuaaucca aaacggggcu     1740

cgggaagacu gucgcgagau gaagauuuac cugagaaaug aauccgaguu cagggauaaa     1800

cuaucaccca uccacaucgc ccucaacuuc agccuggacc cacaggcacc uguggauucu     1860

cacggacuuc gucccgccuu gcauuaucag uccaagaguc ggauugaaga caaggcucag     1920

auacugcucg gcugcgggga ggauaacauc uguguuccag accugcaauu agagguguuu     1980

ggagaacaga aucacgucua ccugggcgau aaaaacgccc uuaauuugac uuuccaugca     2040

cagaacgugg gugaaggggg agcuuacgag gccgagcucc gaguaaccgc gccgccugag     2100

gccgaauaua gcggccuggu gagacacccc gguaauuuuu cuucccuauc augcgacuac     2160

uucgcuguua accaaaguag gcugcucguc ugcgaucugg gcaauccaau gaaggcaggg     2220

gccagccuuu ggggaggcuu gcgcuuuaca gugccccacu ugcgggacac uaaaaagacc     2280

auucaguucg auuuucagau cuuaucgaaa aaccucaaua acucccaguc ugacgugguc     2340

agcuucagac ugucaguuga ggcucaagcc caggugacac uuaauggggu gaguaagccu     2400

gaagcaguac uguuuccagu cuccgacugg caucccaggg aucagccuca ggaggaagag     2460

gacuugggac cggcggugca ccauguuuau gagcucauaa accaaggccc aucuagcauu     2520

ucccagggug ugcuggaacu aucauguccc caggcccugg aggggcagca acuccuguac     2580

gucacccgcg ugacuggacu uaauugcacg acaaaccacc cuaucaaucc aaaaggcuug     2640

gaacuggauc ccgaggguag cuuacaucac cagcagaagc gagaagcucc uagucggucu     2700

uccgccagcu cgggcccgca aauccucaag ugucccgagg cagagugcuu ccgucugaga     2760

ugugaacuug ggccacugca ccagcaggag ucacagucuc uacaacucca uuuuaggguu     2820

ugggcuaaaa ccuuccugca gcgcgaacac cagccuuuua guuugcagug cgaggccgug     2880

uauaaggcac ugaaaaugcc cuaccggauu uuaccaagac aacucccuca gaaggaaagg     2940

cagguagcca cugcugucca guggaccaaa gcggagggau ccuauggcgu gccccugugg     3000

aucauuauac uugccauccu guucggguug cuccugcuag gacugcuuau uuacauccuc     3060

uacaagcugg gcuucuuuaa gcgaagccug ccauauggua cagcaaugga gaaagcucaa     3120

cugaagccgc cugccaccuc ugacgccuga                                      3150


<210>  1607
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAF84259

<400>  1607
augggcagca gaacccccga gagcccccug cacgccgugc agcugagaug gggccccaga       60

agaagacccc cccugcugcc ccugcugcug cugcugcugc cccccccccc cagagugggc      120

ggcuucaacc uggacgccga ggcccccgcc gugcugagcg gcccccccgg cagcuucuuc      180

ggcuucagcg uggaguucua cagacccggc accgacggcg ugagcgugcu ggugggcgcc      240

cccaaggcca acaccagcca gcccggcgug cugcagggcg gcgccgugua ccugugcccc      300

uggggcgcca gccccaccca gugcaccccc aucgaguucg acagcaaggg cagcagacug      360

cuggagagca gccugagcag cagcgagggc gaggagcccg uggaguacaa gagccugcag      420

ugguucggcg ccaccgugag agcccacggc agcagcaucc uggccugcgc cccccuguac      480

agcuggagaa ccgagaagga gccccugagc gaccccgugg gcaccugcua ccugagcacc      540

gacaacuuca ccagaauccu ggaguacgcc cccugcagaa gcgacuucag cugggccgcc      600

ggccagggcu acugccaggg cggcuucagc gccgaguuca ccaagaccgg cagaguggug      660

cugggcggcc ccggcagcua cuucuggcag ggccagaucc ugagcgccac ccaggagcag      720

aucgccgaga gcuacuaccc cgaguaccug aucaaccugg ugcagggcca gcugcagacc      780

agacaggcca gcagcaucua cgacgacagc uaccugggcu acagcguggc cgugggcgag      840

uucagcggcg acgacaccga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggcuacguga ccauccugaa cggcagcgac aucagaagcc uguacaacuu cagcggcgag      960

cagauggcca gcuacuucgc cuacgccgug gccgccaccg acgugaacgg cgacggccug     1020

gacgaccugc uggugggcgc cccccugcug auggacagaa cccccgacgg cagaccccag     1080

gaggugggca gaguguacgu guaccugcag caccccgccg gcaucgagag cacccccacc     1140

cugacccuga ccggccacga cgaguucggc agauucggca gcagccugac cccccugggc     1200

gaccuggacc aggacggcua caacgacgug gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ugguguucgu guuccccggc ggccccggcg gccugggcag caagcccagc     1320

caggugcugc agccccugug ggccgccagc cacacccccg acuucuucgg cagcgcccug     1380

agaggcggca gagaccugga cggcaacggc uaccccgacc ugaucguggg cagcuucggc     1440

guggacaagg ccguggugua cagaggcaga cccaucguga gcgccagcgc cagccugacc     1500

aucuuccccg ccauguucaa ccccgaggag agaagcugca gccuggaggg caaccccgug     1560

gccugcauca accugagcuu cugccugaac gccagcggca agcacguggc cgacagcauc     1620

ggcuucaccg uggagcugca gcuggacugg cagaagcaga agggcggcgu gagaagagcc     1680

cuguuccugg ccagcagaca ggccacccug acccagaccc ugcugaucca gaacggcgcc     1740

agagaggacu gcagagagau gaagaucuac cugagaaacg agagcgaguu cagagacaag     1800

cugagcccca uccacaucgc ccugaacuuc agccuggacc cccaggcccc cguggacagc     1860

cacggccuga gacccgcccu gcacuaccag agcaagagca gaaucgagga caaggcccag     1920

auccugcugg gcugcggcga ggacaacauc ugcgugcccg accugcagcu ggagguguuc     1980

ggcgagcaga accacgugua ccugggcgac aagaacgccc ugaaccugac cuuccacgcc     2040

cagaacgugg gcgagggcgg cgccuacgag gccgagcuga gagugaccgc cccccccgag     2100

gccgaguaca gcggccuggu gagacacccc ggcaacuuca gcagccugag cugcgacuac     2160

uucgccguga accagagcag acugcuggug ugcgaccugg gcaaccccau gaaggccggc     2220

gccagccugu ggggcggccu gagauucacc gugccccacc ugagagacac caagaagacc     2280

auccaguucg acuuccagau ccugagcaag aaccugaaca acagccagag cgacguggug     2340

agcuucagac ugagcgugga ggcccaggcc caggugaccc ugaacggcgu gagcaagccc     2400

gaggccgugc uguuccccgu gagcgacugg caccccagag accagcccca ggaggaggag     2460

gaccugggcc ccgccgugca ccacguguac gagcugauca accagggccc cagcagcauc     2520

agccagggcg ugcuggagcu gagcugcccc caggcccugg agggccagca gcugcuguac     2580

gugaccagag ugaccggccu gaacugcacc accaaccacc ccaucaaccc caagggccug     2640

gagcuggacc ccgagggcag ccugcaccac cagcagaaga gagaggcccc cagcagaagc     2700

agcgccagca gcggccccca gauccugaag ugccccgagg ccgagugcuu cagacugaga     2760

ugcgagcugg gcccccugca ccagcaggag agccagagcc ugcagcugca cuucagagug     2820

ugggccaaga ccuuccugca gagagagcac cagcccuuca gccugcagug cgaggccgug     2880

uacaaggccc ugaagaugcc cuacagaauc cugcccagac agcugcccca gaaggagaga     2940

cagguggcca ccgccgugca guggaccaag gccgagggca gcuacggcgu gccccugugg     3000

aucaucaucc uggccauccu guucggccug cugcugcugg gccugcugau cuacauccug     3060

uacaagcugg gcuucuucaa gagaagccug cccuacggca ccgccaugga gaaggcccag     3120

cugaagcccc ccgccaccag cgacgccuga                                      3150


<210>  1608
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAF84259

<400>  1608
augggcagca gaacccccga guccccucug cacgccgugc agcuccggug ggggccgcgc       60

agacggcccc cucugcuucc ccugcuccug cuucugcucc cucccccucc gcgcgucgga      120

ggcuucaacc uggacgcuga agcccccgcg guucugucug ggccucccgg gagcuuuuuc      180

ggcuuuuccg uggaguucua cagaccuggg acagauggag ugucuguccu cgugggcgcu      240

cccaaggcca auacgagcca accgggcguu cugcagggag gagccgugua ucuuugcccu      300

uggggcgcuu cccccaccca guguacaccu aucgaauuug acucuaaagg gagccggcug      360

cucgagucca gccugucuuc cagcgaagga gaggagcccg ucgaauacaa gucucuucag      420

ugguucggcg ccaccgugcg cgcucauggg uccagcauuc uggccugcgc gccccucuau      480

ucuuggagaa cagagaaaga accucugucc gauccgguug gaaccuguua ccugagcaca      540

gacaacuuua cccggauccu cgaguaugcc cccugccgcu ccgauuucuc uugggcugcc      600

ggccaaggcu acugucaagg gggauuuagc gcugaguuca cgaagaccgg cagagugguc      660

cuugggggac cuggcuccua uuuuuggcag gggcagauuc ugagcgccac acaggaacag      720

aucgcggagu cuuacuaccc cgaauaucug auuaaucucg ugcagggaca gcugcaaacc      780

cggcaggccu ccagcaucua cgacgauucu uaucuuggcu acagcguggc ugucggcgag      840

uucuccgggg acgauacaga agacuuuguu gccggagugc cuaaaggcaa ccugaccuau      900

ggguacguga cgauccucaa uggaucugau auucgcagcc uguauaacuu cuccggcgag      960

cagauggcua gcuacuucgc cuacgccguc gcugcgacag acgugaaugg ggauggccug     1020

gacgaccucc ugguuggagc cccgcuucug auggauagaa ccccggacgg ccggccucaa     1080

gagguggggc gcgucuaugu guaccuccag caccccgcug gaaucgaauc uacaccuacc     1140

cugacccuua caggccauga ugaguuuggg agauucggau ccagccugac gccccucggc     1200

gaccuggauc aggacgggua uaacgauguu gccauuggcg ccccuuuugg aggcgaaacc     1260

cagcaagggg uggucuucgu guuucccgga ggccccgggg gacugggcuc uaagccuucc     1320

cagguccucc agccccugug ggcugccagc cacacacccg acuucuuugg guccgcgcuu     1380

cggggcggaa gagaucugga cggcaauggg uacccugauc ucaucguggg aucuuucggc     1440

guugacaagg cuguggucua ucgcgggcgg ccgauuguga gcgccuccgc cucucugacc     1500

aucuuucccg cuauguucaa cccugaggaa agaagcugcu cccuggaggg aaaucccguu     1560

gccuguauua accuuagcuu uugccucaau gcuucuggca aacauguggc cgacuccauc     1620

ggguucacag ucgagcugca gcuggauugg caaaagcaga aaggcggagu gcgccgggcg     1680

cucuuucugg ccagcagaca ggcuacccuu acgcagacac ugcucaucca aaacggcgcc     1740

cgcgaagacu gucgggagau gaagauuuac cugagaaaug aaucugaguu ccgcgauaaa     1800

cuguccccua uccacauugc ucuuaacuuc agccucgacc cccaggcccc uguggauucu     1860

cacgggcugc ggcccgcgcu gcauuaucag agcaagucca gaaucgaaga caaggcccag     1920

auucuccugg gaugcggcga ggauaacauc uguguuccgg accuucaacu ggaggucuuu     1980

ggggaacaga aucacgugua ccucggagau aaaaacgcuc ugaaucugac cuuccaugcc     2040

cagaacgugg gcgagggcgg ggcuuacgaa gccgagcuuc gcgucaccgc cccucccgag     2100

gcugaauaua gcggacucgu gcggcacccu ggcaauuuuu cuucccugag cugcgacuac     2160

uucgcgguua accaauccag acugcucgug ugcgaucugg ggaaucccau gaaggccgga     2220

gcuucucuuu ggggcgggcu gcgguuuaca gucccgcacc uccgcgacac caaaaagaca     2280

auccaguucg auuuucagau ucugagcaaa aaccugaaua acucccaguc ugacgugguu     2340

agcuucagac uuuccgugga ggcccaagcc caggucacgc ucaauggagu gucuaagccu     2400

gaagcuguuc uguuucccgu gagcgacugg cauccucggg aucagcccca ggaggaagag     2460

gaccugggcc ccgccgucca ccauguguau gagcucauca accaaggccc uuccagcauu     2520

ucucaggggg ugcuggaacu uuccuguccg caggcgcugg agggacagca acuccuguac     2580

gucaccagag uuacaggccu gaauugcacc acaaaccacc ccaucaaucc uaaagggcuu     2640

gaacuggauc ccgagggaag ccuccaucac cagcagaagc gcgaagcucc uucucggucc     2700

agcgccucuu ccggccccca aauucugaag uguccugagg ccgagugcuu cagacuccgc     2760

ugugaacugg ggccgcuuca ccagcaggag agccaguccc ugcaacucca uuuuagagug     2820

ugggcuaaaa ccuuccugca gcgggaacac cagcccuuua gccugcagug cgaggccgug     2880

uauaaggcgc uuaaaaugcc uuaccgcauc cugcccagac aacucccuca gaaggaacgg     2940

caggucgcua cggccgugca guggaccaaa gccgagggau cuuauggcgu uccccugugg     3000

aucauuaucc ucgcuauucu guucggccuu cugcuccugg ggcugcuuau cuacauucug     3060

uacaagcucg gauucuuuaa gcgcagccug ccguauggca cagccaugga gaaagcucaa     3120

cucaagccuc ccgccaccuc cgacgcguga                                      3150


<210>  1609
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B2R627

<400>  1609

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Gly Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Leu Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp Ile Ile Ile Leu Ala Ile Leu Phe 
        995                 1000                1005            


Gly Leu Leu Leu Leu Gly Leu Leu Ile Tyr Ile Leu Tyr Lys Leu Gly 
    1010                1015                1020                


Phe Phe Lys Arg Ser Leu Pro Tyr Gly Thr Ala Met Glu Lys Ala Gln 
1025                1030                1035                1040


Leu Lys Pro Pro Ala Thr Ser Asp Ala 
                1045                


<210>  1610
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG35324

<400>  1610
auggggagcc ggacgccaga guccccucuc cacgccgugc agcugcgcug gggcccccgg       60

cgccgacccc cgcugcugcc gcugcuguug cugcugcugc cgccgccacc cagggucggg      120

ggcuucaacu uagacgcgga ggccccagca guacucucgg ggcccccggg cuccuucuuc      180

ggauucucag uggaguuuua ccggccggga acagacgggg ucagugugcu ggugggagca      240

cccaaggcua auaccagcca gccaggagug cugcagggug gugcugucua ccucuguccu      300

uggggugcca gccccacaca gugcaccccc auugaauuug acagcaaagg cucucggcuc      360

cuggaguccu cacuguccag cucagaggga gaggagccug uggaguacaa guccuugcag      420

ugguucgggg caacaguucg agcccauggc uccuccaucu uggcaugcgc uccacuguac      480

agcuggcgca cagagaagga gccacugagc gaccccgugg gcaccugcua ccucuccaca      540

gauaacuuca cccgaauucu ggaguaugca cccugccgcu cagauuucag cugggcagca      600

ggacaggguu acugccaagg aggcuucagu gccgaguuca ccaagacugg ccgugugguu      660

uuagguggac caggaagcua uuucuggcaa ggccagaucc ugucugccac ucaggagcag      720

auugcagaau cuuauuaccc cgaguaccug aucaaccugg uucaggggca gcugcagacu      780

cgccaggcca guuccaucua ugaugacagc uaccuaggau acucuguggc uguuggugaa      840

uucaguggug augacacaga agacuuuguu gcuggugugc ccaaagggaa ccucacuuac      900

ggcuauguca ccauccuuaa uggcucagac auucgauccc ucuacaacuu cucaggggaa      960

cagauggccu ccuacuuugg cuaugcagug gccgccacag acgucaaugg ggacgggcug     1020

gaugacuugc uggugggggc accccugcuc auggaucgga ccccugacgg gcggccucag     1080

ggggugggca gggucuacgu cuaccugcag cacccagccg gcauagagcc cacgcccacc     1140

cuuacccuca cuggccauga ugaguuuggc cgauuuggca gcuccuugac cccccugggg     1200

gaccuggacc aggauggcua caaugaugug gccaucgggg cucccuuugg uggggagacc     1260

cagcagggag uaguguuugu auuuccuggg ggcccaggag ggcugggcuc uaagcuuucc     1320

cagguucugc agccccugug ggcagccagc cacaccccag acuucuuugg cucugcccuu     1380

cgaggaggcc gagaccugga uggcaaugga uauccugauc ugauuguggg guccuuuggu     1440

guggacaagg cugugguaua caggggccgc cccaucgugu ccgcuagugc cucccucacc     1500

aucuuccccg ccauguucaa cccagaggag cggagcugca gcuuagaggg gaacccugug     1560

gccugcauca accuuagcuu cugccucaau gcuucuggaa aacacguugc ugacuccauu     1620

gguuucacag uggaacuuca gcuggacugg cagaagcaga agggaggggu acggcgggca     1680

cuguuccugg ccuccaggca ggcaacccug acccagaccc ugcucaucca gaauggggcu     1740

cgagaggauu gcagagagau gaagaucuac cucaggaacg agucagaauu ucgagacaaa     1800

cucucgccga uucacaucgc ucucaacuuc uccuuggacc cccaagcccc aguggacagc     1860

cacggccuca ggccagcccu acauuaucag agcaagagcc ggauagagga caaggcucag     1920

aucuugcugg acuguggaga agacaacauc ugugugccug accugcagcu ggaaguguuu     1980

ggggagcaga accaugugua ccugggugac aagaaugccc ugaaccucac uuuccaugcc     2040

cagaaugugg gugagggugg cgccuaugag gcugagcuuc gggucaccgc cccuccagag     2100

gcugaguacu caggacucgu cagacaccca gggaacuucu ccagccugag cugugacuac     2160

uuugccguga accagagccg ccugcuggug ugugaccugg gcaaccccau gaaggcagga     2220

gccagucugu gggguggccu ucgguuuaca gucccucauc uccgggacac uaagaaaacc     2280

auccaguuug acuuccagau ccucagcaag aaucucaaca acucgcaaag cgacgugguu     2340

uccuuucggc ucuccgugga ggcucaggcc caggucaccc ugaacggugu cuccaagccu     2400

gaggcagugc uauucccagu aagcgacugg cauccccgag accagccuca gaaggaggag     2460

gaccugggac cugcugucca ccaugucuau gagcucauca accaaggccc cagcuccauu     2520

agccagggug ugcuggaacu cagcuguccc caggcucugg aaggucagca gcuccuauau     2580

gugaccagag uuacgggacu caacugcacc accaaucacc ccauuaaccc aaagggccug     2640

gaguuggauc ccgaggguuc ccugcaccac cagcaaaaac gggaagcucc aagccgcagc     2700

ucugcuuccu cgggaccuca gauccugaaa ugcccggagg cugaguguuu caggcugcgc     2760

ugugagcucg ggccccugca ccaacaagag agccaaaguc ugcaguugca uuuccgaguc     2820

ugggccaaga cuuucuugca gcgggagcac cagccauuua gccugcagug ugaggcugug     2880

uacaaagccc ugaagaugcc cuaccgaauc cugccucggc agcugcccca aaaagagcgu     2940

cagguggcca cagcugugca auggaccaag gcagaaggca gcuauggcgu cccacugugg     3000

aucaucaucc uagccauccu guuuggccuc cugcuccuag gucuacucau cuacauccuc     3060

uacaagcuug gauucuucaa acgcucccuc ccauauggca ccgccaugga aaaagcucag     3120

cucaagccuc cagccaccuc ugaugccuga                                      3150


<210>  1611
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG35324

<400>  1611
augggcagcc gcacccccga guccccgcug cacgccgugc agcuccggug ggggccccgc       60

cggcgcccgc cccugcugcc ccuccugcug cuccugcugc ccccgccgcc ccgggucggc      120

ggguucaacc ucgacgccga ggcgcccgcc gugcugagcg gcccgcccgg guccuucuuc      180

ggcuucagcg uggaguucua ccgccccggc accgacgggg ucuccgugcu ggugggcgcc      240

cccaaggcca acacgagcca gcccgggguc cuccagggcg gggccgugua ccugugcccc      300

uggggcgcgu cccccaccca gugcaccccc aucgaguucg acagcaaggg cucccggcug      360

cucgagagcu cccugagcuc cagcgagggg gaggagcccg uggaguacaa gucccugcag      420

ugguucggcg ccaccguccg cgcccacggg agcuccaucc ucgccugcgc gccccuguac      480

agcuggcgga cggagaagga gccgcugucc gaccccgugg ggaccugcua ccucagcacc      540

gacaacuuca cccgcauccu ggaguacgcc cccugccgga gcgacuucuc cugggccgcc      600

ggccagggcu acugccaggg cggguucagc gccgaguuca cgaagaccgg ccgcgugguc      660

cucgggggcc ccggcuccua cuucuggcag gggcagaucc ugagcgcgac ccaggagcag      720

aucgccgagu ccuacuaccc ggaguaccug aucaaccugg ugcagggcca gcuccagacc      780

cggcaggcca gcuccaucua cgacgacagc uaccuggggu acuccguggc cgucggcgag      840

uucagcgggg acgacacgga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggguacguca ccauccucaa cggcuccgac auccgcagcc uguacaacuu cuccggggag      960

cagauggcga gcuacuucgg cuacgccgug gccgccaccg acgugaacgg ggacggccug     1020

gacgaccucc uggucggcgc gccccugcuc auggaccgga cgcccgacgg gcgcccgcag     1080

ggcguggggc ggguguacgu cuaccugcag caccccgccg gcaucgagcc caccccgacc     1140

cugacccuca cgggccacga cgaguucggg cgcuucggcu ccagccugac gccccugggg     1200

gaccucgacc aggacggcua caacgacgug gccaucgggg cccccuucgg cggcgagacc     1260

cagcaggggg ucguguucgu guuccccggc gggccgggcg ggcugggcuc caagcugagc     1320

cagguccucc agccccugug ggccgccucc cacacccccg acuucuucgg cagcgcgcug     1380

cgcgggggcc gggaccucga cgggaacggc uaccccgacc ugaucguggg gagcuucggc     1440

guggacaagg ccgucgugua ccggggccgc ccgaucgugu ccgccagcgc cucccugacc     1500

aucuuccccg cgauguucaa ccccgaggag cgcagcugcu cccuggaggg gaaccccguc     1560

gccugcauca accucagcuu cugccugaac gccuccggca agcacguggc cgacagcauc     1620

ggguucaccg uggagcugca gcucgacugg cagaagcaga agggcggggu ccggcgcgcc     1680

cuguuccugg cgucccggca ggccacccuc acccagacgc ugcugaucca gaacggcgcc     1740

cgcgaggacu gccgggagau gaagaucuac cuccgcaacg agagcgaguu ccgggacaag     1800

cuguccccga uccacaucgc ccugaacuuc agccucgacc cccaggcccc cguggacucc     1860

cacggccugc gccccgcgcu gcacuaccag agcaaguccc ggaucgagga caaggcccag     1920

auccuccugg acugcgggga ggacaacauc ugcgugccgg accugcagcu cgaggucuuc     1980

ggcgagcaga accacgugua ccugggggac aagaacgccc ugaaccucac cuuccacgcc     2040

cagaacgugg gcgagggcgg ggccuacgag gcggagcugc gcgucaccgc cccgcccgag     2100

gccgaguaca gcggccuggu gcggcacccc gggaacuucu ccagccucag cugcgacuac     2160

uucgccguga accagucccg ccugcugguc ugcgaccucg gcaaccccau gaaggcgggg     2220

gccagccugu ggggcggccu gcgguucacc gugccccacc uccgcgacac gaagaagacc     2280

auccaguucg acuuccagau ccuguccaag aaccugaaca acagccaguc cgacgugguc     2340

agcuuccggc ucuccgugga ggcccaggcc caggugaccc ugaacggggu cagcaagccc     2400

gaggccgugc uguuccccgu guccgacugg cacccgcgcg accagcccca gaaggaggag     2460

gaccucggcc ccgcggucca ccacguguac gagcugauca accaggggcc gagcuccauc     2520

agccagggcg ugcuggagcu cuccugcccc caggcccugg aggggcagca gcugcucuac     2580

gucacccggg ugacgggccu gaacugcacc accaaccacc ccaucaaccc caagggccug     2640

gagcucgacc cggaggggag ccugcaccac cagcagaagc gcgaggcccc cucccggagc     2700

uccgccagcu ccggccccca gauccugaag ugccccgagg ccgagugcuu ccgccuccgc     2760

ugcgagcugg ggccgcugca ccagcaggag agccagagcc uccagcugca cuuccgggug     2820

ugggcgaaga ccuuccugca gcgcgagcac cagcccuucu cccuccagug cgaggccguc     2880

uacaaggccc ugaagaugcc cuaccggauc cugccccgcc agcucccgca gaaggagcgc     2940

cagguggcca ccgccgugca guggacgaag gcggagggca gcuacggggu cccccugugg     3000

aucaucaucc uggccauccu cuucggccug cugcuccugg gccugcucau cuacauccug     3060

uacaagcugg gguucuucaa gcggucccuc cccuacggca ccgccaugga gaaggcccag     3120

cugaagcccc cggcgaccag cgacgccuga                                      3150


<210>  1612
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG35324

<400>  1612
augggcuccc gcacccccga guccccccuc cacgccgucc agcuccgcug gggcccccgc       60

cgccgccccc cccuccuccc ccuccuccuc cuccuccucc cccccccccc ccgcgucggc      120

ggcuucaacc ucgacgccga ggcccccgcc guccucuccg gcccccccgg cuccuucuuc      180

ggcuucuccg ucgaguucua ccgccccggc accgacggcg ucuccguccu cgucggcgcc      240

cccaaggcca acaccuccca gcccggcguc cuccagggcg gcgccgucua ccucugcccc      300

uggggcgccu cccccaccca gugcaccccc aucgaguucg acuccaaggg cucccgccuc      360

cucgaguccu cccucuccuc cuccgagggc gaggagcccg ucgaguacaa gucccuccag      420

ugguucggcg ccaccguccg cgcccacggc uccuccaucc ucgccugcgc cccccucuac      480

uccuggcgca ccgagaagga gccccucucc gaccccgucg gcaccugcua ccucuccacc      540

gacaacuuca cccgcauccu cgaguacgcc cccugccgcu ccgacuucuc cugggccgcc      600

ggccagggcu acugccaggg cggcuucucc gccgaguuca ccaagaccgg ccgcgucguc      660

cucggcggcc ccggcuccua cuucuggcag ggccagaucc ucuccgccac ccaggagcag      720

aucgccgagu ccuacuaccc cgaguaccuc aucaaccucg uccagggcca gcuccagacc      780

cgccaggccu ccuccaucua cgacgacucc uaccucggcu acuccgucgc cgucggcgag      840

uucuccggcg acgacaccga ggacuucguc gccggcgucc ccaagggcaa ccucaccuac      900

ggcuacguca ccauccucaa cggcuccgac auccgcuccc ucuacaacuu cuccggcgag      960

cagauggccu ccuacuucgg cuacgccguc gccgccaccg acgucaacgg cgacggccuc     1020

gacgaccucc ucgucggcgc cccccuccuc auggaccgca cccccgacgg ccgcccccag     1080

ggcgucggcc gcgucuacgu cuaccuccag caccccgccg gcaucgagcc cacccccacc     1140

cucacccuca ccggccacga cgaguucggc cgcuucggcu ccucccucac cccccucggc     1200

gaccucgacc aggacggcua caacgacguc gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ucgucuucgu cuuccccggc ggccccggcg gccucggcuc caagcucucc     1320

cagguccucc agccccucug ggccgccucc cacacccccg acuucuucgg cuccgcccuc     1380

cgcggcggcc gcgaccucga cggcaacggc uaccccgacc ucaucgucgg cuccuucggc     1440

gucgacaagg ccgucgucua ccgcggccgc cccaucgucu ccgccuccgc cucccucacc     1500

aucuuccccg ccauguucaa ccccgaggag cgcuccugcu cccucgaggg caaccccguc     1560

gccugcauca accucuccuu cugccucaac gccuccggca agcacgucgc cgacuccauc     1620

ggcuucaccg ucgagcucca gcucgacugg cagaagcaga agggcggcgu ccgccgcgcc     1680

cucuuccucg ccucccgcca ggccacccuc acccagaccc uccucaucca gaacggcgcc     1740

cgcgaggacu gccgcgagau gaagaucuac cuccgcaacg aguccgaguu ccgcgacaag     1800

cucuccccca uccacaucgc ccucaacuuc ucccucgacc cccaggcccc cgucgacucc     1860

cacggccucc gccccgcccu ccacuaccag uccaaguccc gcaucgagga caaggcccag     1920

auccuccucg acugcggcga ggacaacauc ugcguccccg accuccagcu cgaggucuuc     1980

ggcgagcaga accacgucua ccucggcgac aagaacgccc ucaaccucac cuuccacgcc     2040

cagaacgucg gcgagggcgg cgccuacgag gccgagcucc gcgucaccgc cccccccgag     2100

gccgaguacu ccggccucgu ccgccacccc ggcaacuucu ccucccucuc cugcgacuac     2160

uucgccguca accagucccg ccuccucguc ugcgaccucg gcaaccccau gaaggccggc     2220

gccucccucu ggggcggccu ccgcuucacc gucccccacc uccgcgacac caagaagacc     2280

auccaguucg acuuccagau ccucuccaag aaccucaaca acucccaguc cgacgucguc     2340

uccuuccgcc ucuccgucga ggcccaggcc caggucaccc ucaacggcgu cuccaagccc     2400

gaggccgucc ucuuccccgu cuccgacugg cacccccgcg accagcccca gaaggaggag     2460

gaccucggcc ccgccgucca ccacgucuac gagcucauca accagggccc cuccuccauc     2520

ucccagggcg uccucgagcu cuccugcccc caggcccucg agggccagca gcuccucuac     2580

gucacccgcg ucaccggccu caacugcacc accaaccacc ccaucaaccc caagggccuc     2640

gagcucgacc ccgagggcuc ccuccaccac cagcagaagc gcgaggcccc cucccgcucc     2700

uccgccuccu ccggccccca gauccucaag ugccccgagg ccgagugcuu ccgccuccgc     2760

ugcgagcucg gcccccucca ccagcaggag ucccaguccc uccagcucca cuuccgcguc     2820

ugggccaaga ccuuccucca gcgcgagcac cagcccuucu cccuccagug cgaggccguc     2880

uacaaggccc ucaagaugcc cuaccgcauc cucccccgcc agcuccccca gaaggagcgc     2940

caggucgcca ccgccgucca guggaccaag gccgagggcu ccuacggcgu cccccucugg     3000

aucaucaucc ucgccauccu cuucggccuc cuccuccucg gccuccucau cuacauccuc     3060

uacaagcucg gcuucuucaa gcgcucccuc cccuacggca ccgccaugga gaaggcccag     3120

cucaagcccc ccgccaccuc cgacgccuga                                      3150


<210>  1613
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG35324

<400>  1613
augggcagca gaacccccga guccccucug cacgccgugc agcucaggug ggggccacgg       60

cgccgaccgc cccuucugcc uuuguuacug cuacuccugc cacccccucc acgugucgga      120

gguuucaacc uugacgcuga agcacccgcc guucugucug gcccuccagg gucauuuuuc      180

ggauuuagug uggaguucua cagaccgggc acagauggug uaagcguguu ggucggggcg      240

cccaaggcua auacuuccca accuggagug cuccagggcg gcgccguuua ucugugccca      300

uggggagcau cucccacgca guguaccccu aucgaauuug acucgaaagg gucaaggcug      360

cucgagagca guuuauccuc uagcgaaggu gaggagccag uggaauacaa gucccugcag      420

ugguucggcg ccacaguccg ggcucauggg ucaaguauuc uugcaugcgc ccccuuguau      480

agcuggcgca cugagaaaga accgcugucu gauccugugg gaaccuguua ccuauccaca      540

gacaacuuua ccagaauacu cgaguaugcu cccugcaggu cagauuucag cugggccgcg      600

ggccaagguu acugucaagg gggauuuagu gcagaguuca cuaagacagg ccggguaguu      660

cugggcgggc caggaucuua uuuuuggcag ggucagaucc uuuccgccac ccaggaacag      720

auugcugaga gcuacuaccc ugaauaucug aucaauuugg ugcagggcca gcuccaaacg      780

cgccaggccu cgucuauuua cgacgauucc uaucuggggu acucagucgc agugggagag      840

uucaguggcg acgauacuga agacuuugug gcuggugucc ccaaagggaa cuuaaccuau      900

ggcuacguua caauccugaa uggaagcgau auacgauccc ucuauaacuu cucuggcgag      960

cagauggcca gcuacuucgg guacgcggug gccgcaacug acguaaaugg agauggucuu     1020

gacgaccugu uggugggcgc uccacuacug auggauagaa cccccgacgg gaggccucaa     1080

ggagucggcc ggguguaugu uuaccuccag cacccagccg guaucgagcc gacacccacc     1140

cugacgcuua cugggcauga ugaauuuggc cguuucggau caagucugac accuuugggc     1200

gaccucgauc aggacgggua uaacgaugug gcuauuggag ccccauuugg uggcgagacc     1260

cagcaagggg ucguguucgu auuucccgga ggcccuggug ggcugggcuc caaguuaagc     1320

cagguucugc agccacuaug ggcagccucu cacacucccg acuucuuugg aucagcucuc     1380

cgcggcggga gagaucugga cggaaauggc uacccggauc uuaucguggg uaguuucggg     1440

gucgacaagg cgguggucua uaggggacgg ccuauuguga gcgcauccgc cucuuugaca     1500

aucuuuccag cuauguucaa ccccgaagaa cgaucgugca gccuggaagg caauccuguu     1560

gccuguauaa accucuccuu uugccugaau gcaucaggua aacauguggc cgacaguauu     1620

ggcuucaccg uagagcuuca gcuggauugg caaaagcaga aagggggagu ccgcagagcu     1680

uuguuucucg ccucuaggca ggcaacgcug acccagacau uacugaucca aaacggcgcg     1740

cgggaggacu gucgcgaaau gaagauuuac cuaagaaaug agagcgaguu cagggauaaa     1800

cucuccccca uccacaucgc ucugaacuuc ucacuugacc cacaggcccc uguggauagc     1860

cacggguugc gucccgcacu gcauuaucag ucuaaguccc ggauugagga caaggcccag     1920

auacuccugg auugcggaga agacaacauc uguguuccag auuuacaacu ggagguguuu     1980

ggcgagcaga aucacgucua ccuuggugac aaaaacgcuu ugaaucucac uuuccaugcc     2040

cagaacgugg gggaaggagg cgcauacgag gcugaacugc gaguaaccgc cccgccugag     2100

gcggaguaua guggucuagu gagacacccc ggcaauuuua gcucucuguc cugcgauuac     2160

uucgccguua accaaucaag gcuccugguc ugcgaccuug ggaauccaau gaaggcugga     2220

gcaaguuugu ggggcgggcu gcgcuuuaca gugccccacu uacgggauac uaaaaagacc     2280

auucaguucg acuuucagau ccucagcaaa aaccugaaua acucgcaguc cgacgugguc     2340

ucuuucagac uuagcguuga agcccaagcu caggugacac ugaauggagu gucaaagccu     2400

gaggccguau uguuuccagu cagugauugg caucccaggg accagccuca gaaagaagag     2460

gaucucggcc cggcagugca ccauguuuau gaacugauaa accaaggucc auccucuauu     2520

agccaggggg ugcuagagcu guccuguccc caggcgcucg agggacagca acugcuuuac     2580

gucacccgcg ugacuggcuu gaauugcacg acaaaccacc cuaucaaucc aaagggucug     2640

gaauuagacc ccgagggcuc acuccaucac cagcagaagc gagaagcccc uagccggagu     2700

ucugcuucca gcgggccgca aauccugaaa ugucccgagg ccgaaugcuu ccgucuuaga     2760

ugugagcugg gaccacuaca ccagcaggag ucgcagucac uccaacugca uuuuaggguu     2820

ugggcaaaga ccuucuugca gcgcgaacac cagccuuuuu cucugcagug cgaggcugug     2880

uauaaagccu uaaagaugcc cuaccggauu cucccaagac aacugccuca gaaagaaagg     2940

cagguagcaa cugccgucca guggaccaag gcugagggca guuauggggu gccccuuugg     3000

aucauuauac uggcgaucuu guucggacuc cugcuacugg gccuucucau uuacauccug     3060

uacaaguugg guuucuuuaa acgaucccug ccauauggga cagccaugga aaaggcacaa     3120

uuaaaaccgc cugcuaccag cgaugccuga                                      3150


<210>  1614
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG35324

<400>  1614
augggcagca gaacccccga gagcccccug cacgccgugc agcugagaug gggccccaga       60

agaagacccc cccugcugcc ccugcugcug cugcugcugc cccccccccc cagagugggc      120

ggcuucaacc uggacgccga ggcccccgcc gugcugagcg gcccccccgg cagcuucuuc      180

ggcuucagcg uggaguucua cagacccggc accgacggcg ugagcgugcu ggugggcgcc      240

cccaaggcca acaccagcca gcccggcgug cugcagggcg gcgccgugua ccugugcccc      300

uggggcgcca gccccaccca gugcaccccc aucgaguucg acagcaaggg cagcagacug      360

cuggagagca gccugagcag cagcgagggc gaggagcccg uggaguacaa gagccugcag      420

ugguucggcg ccaccgugag agcccacggc agcagcaucc uggccugcgc cccccuguac      480

agcuggagaa ccgagaagga gccccugagc gaccccgugg gcaccugcua ccugagcacc      540

gacaacuuca ccagaauccu ggaguacgcc cccugcagaa gcgacuucag cugggccgcc      600

ggccagggcu acugccaggg cggcuucagc gccgaguuca ccaagaccgg cagaguggug      660

cugggcggcc ccggcagcua cuucuggcag ggccagaucc ugagcgccac ccaggagcag      720

aucgccgaga gcuacuaccc cgaguaccug aucaaccugg ugcagggcca gcugcagacc      780

agacaggcca gcagcaucua cgacgacagc uaccugggcu acagcguggc cgugggcgag      840

uucagcggcg acgacaccga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggcuacguga ccauccugaa cggcagcgac aucagaagcc uguacaacuu cagcggcgag      960

cagauggcca gcuacuucgg cuacgccgug gccgccaccg acgugaacgg cgacggccug     1020

gacgaccugc uggugggcgc cccccugcug auggacagaa cccccgacgg cagaccccag     1080

ggcgugggca gaguguacgu guaccugcag caccccgccg gcaucgagcc cacccccacc     1140

cugacccuga ccggccacga cgaguucggc agauucggca gcagccugac cccccugggc     1200

gaccuggacc aggacggcua caacgacgug gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ugguguucgu guuccccggc ggccccggcg gccugggcag caagcugagc     1320

caggugcugc agccccugug ggccgccagc cacacccccg acuucuucgg cagcgcccug     1380

agaggcggca gagaccugga cggcaacggc uaccccgacc ugaucguggg cagcuucggc     1440

guggacaagg ccguggugua cagaggcaga cccaucguga gcgccagcgc cagccugacc     1500

aucuuccccg ccauguucaa ccccgaggag agaagcugca gccuggaggg caaccccgug     1560

gccugcauca accugagcuu cugccugaac gccagcggca agcacguggc cgacagcauc     1620

ggcuucaccg uggagcugca gcuggacugg cagaagcaga agggcggcgu gagaagagcc     1680

cuguuccugg ccagcagaca ggccacccug acccagaccc ugcugaucca gaacggcgcc     1740

agagaggacu gcagagagau gaagaucuac cugagaaacg agagcgaguu cagagacaag     1800

cugagcccca uccacaucgc ccugaacuuc agccuggacc cccaggcccc cguggacagc     1860

cacggccuga gacccgcccu gcacuaccag agcaagagca gaaucgagga caaggcccag     1920

auccugcugg acugcggcga ggacaacauc ugcgugcccg accugcagcu ggagguguuc     1980

ggcgagcaga accacgugua ccugggcgac aagaacgccc ugaaccugac cuuccacgcc     2040

cagaacgugg gcgagggcgg cgccuacgag gccgagcuga gagugaccgc cccccccgag     2100

gccgaguaca gcggccuggu gagacacccc ggcaacuuca gcagccugag cugcgacuac     2160

uucgccguga accagagcag acugcuggug ugcgaccugg gcaaccccau gaaggccggc     2220

gccagccugu ggggcggccu gagauucacc gugccccacc ugagagacac caagaagacc     2280

auccaguucg acuuccagau ccugagcaag aaccugaaca acagccagag cgacguggug     2340

agcuucagac ugagcgugga ggcccaggcc caggugaccc ugaacggcgu gagcaagccc     2400

gaggccgugc uguuccccgu gagcgacugg caccccagag accagcccca gaaggaggag     2460

gaccugggcc ccgccgugca ccacguguac gagcugauca accagggccc cagcagcauc     2520

agccagggcg ugcuggagcu gagcugcccc caggcccugg agggccagca gcugcuguac     2580

gugaccagag ugaccggccu gaacugcacc accaaccacc ccaucaaccc caagggccug     2640

gagcuggacc ccgagggcag ccugcaccac cagcagaaga gagaggcccc cagcagaagc     2700

agcgccagca gcggccccca gauccugaag ugccccgagg ccgagugcuu cagacugaga     2760

ugcgagcugg gcccccugca ccagcaggag agccagagcc ugcagcugca cuucagagug     2820

ugggccaaga ccuuccugca gagagagcac cagcccuuca gccugcagug cgaggccgug     2880

uacaaggccc ugaagaugcc cuacagaauc cugcccagac agcugcccca gaaggagaga     2940

cagguggcca ccgccgugca guggaccaag gccgagggca gcuacggcgu gccccugugg     3000

aucaucaucc uggccauccu guucggccug cugcugcugg gccugcugau cuacauccug     3060

uacaagcugg gcuucuucaa gagaagccug cccuacggca ccgccaugga gaaggcccag     3120

cugaagcccc ccgccaccag cgacgccuga                                      3150


<210>  1615
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG35324

<400>  1615
augggcagca gaacccccga guccccucug cacgccgugc agcuccggug ggggccgcgc       60

agacggcccc cucugcuucc ccugcuccug cuucugcucc cucccccucc gcgcgucgga      120

ggcuucaacc uggacgcuga agcccccgcg guucugucug ggccucccgg gagcuuuuuc      180

ggcuuuuccg uggaguucua cagaccuggg acagauggag ugucuguccu cgugggcgcu      240

cccaaggcca auacgagcca accgggcguu cugcaagggg gagccgugua ucuuugcccu      300

uggggcgcuu cccccaccca guguacaccu aucgaauuug acucuaaagg gagccggcug      360

cucgagucca gccugucuuc cagcgaagga gaggagcccg ucgaauacaa gucucuucag      420

ugguucggcg ccaccgugcg cgcucauggg uccagcauuc uggccugcgc gccccucuau      480

ucuuggagaa cagagaaaga accucugucc gauccgguug gaaccuguua ccugagcaca      540

gacaacuuua cccggauccu cgaguaugcc cccugccgcu ccgauuucuc uugggcugcc      600

ggccagggcu acugucaagg gggauuuagc gcugaguuca cgaagaccgg cagagugguc      660

cuugggggac cuggcuccua uuuuuggcag gggcagauuc ugagcgccac acaggaacag      720

aucgcggagu cuuacuaccc cgaauaucug auuaaucucg ugcagggaca gcugcaaacc      780

cggcaggccu ccagcaucua cgacgauucu uaucuuggcu acagcguggc ugucggcgag      840

uucuccgggg acgauacaga agacuuuguu gccggagugc cuaaaggcaa ccugaccuau      900

ggguacguga cgauccucaa uggaucugau auucgcagcc uguauaacuu cuccggcgag      960

cagauggcua gcuacuucgg guacgccguc gccgcuacag acgugaaugg cgauggacug     1020

gacgaccucc ugguuggcgc gccccuucug auggauagaa ccccggacgg gcggccucaa     1080

ggagugggcc gcgucuaugu guaccuccag caccccgccg ggaucgagcc uacacccacc     1140

cugacccuua caggacauga ugaauuuggc agauucgggu cuucccugac gccucucggc     1200

gaccuggauc aggacggaua uaacgauguu gcuauuggcg cccccuuugg gggagagacc     1260

cagcaaggcg uggucuucgu guuuccuggg ggaccgggcg ggcugggcag caagcucucu     1320

cagguccugc agccccuuug ggccgcuucc cacacacccg acuucuuugg aagcgcccug     1380

cggggcggga gagaucucga cggaaauggc uacccugauc ugaucguggg guccuucgga     1440

guugacaagg cgguggucua ucgcggccgg ccgauugugu cugcuagcgc cucccugacc     1500

aucuuucccg ccauguucaa cccugaagag agaucuugca gccuugaagg gaaucccguu     1560

gcuuguauua accucuccuu uugccugaau gccagcggca aacauguggc ugacucuauc     1620

ggauucacag ucgagcugca gcucgauugg caaaagcaga aaggcggggu gcgccgggcc     1680

cuguuucuug cguccagaca ggccacccug acgcagacac uccugaucca aaacggagcu     1740

cgcgaggacu gucgggaaau gaagauuuac cugagaaaug agagcgaguu ccgcgauaaa     1800

cuuucuccua uccacauugc ccucaacuuc ucccuggacc cccaggcucc uguggauagc     1860

cacggccugc ggcccgcccu ccauuaucag ucuaagagca gaaucgaaga caaggcgcag     1920

auucugcuug auugcgggga agacaacauc uguguuccgg aucugcaacu cgaggucuuu     1980

ggagagcaga aucacgugua ccugggcgac aaaaacgccc ugaaucuuac cuuccaugcu     2040

cagaacgugg gcgaaggggg agccuacgag gcugaacucc gcgucaccgc cccucccgag     2100

gccgaguauu ccggccuggu gcggcacccu gggaauuuua gcucucuguc cugcgauuac     2160

uucgcuguua accaaagcag acuccuggug ugcgaccuug gaaaucccau gaaggcgggc     2220

gccucccugu ggggaggacu ccgguuuaca gucccgcauc ugcgcgauac caaaaagaca     2280

auccaguucg acuuucagau ucugucuaaa aaccuuaaua acagccaguc cgacgugguu     2340

ucuuucagac ucagcgugga agcucaagcc caggucacgc ugaauggcgu guccaagccu     2400

gaggccguuc uguuucccgu gucugauugg cacccucggg accagcccca gaaagaagag     2460

gaucucggcc ccgcugucca ccauguguau gaacugauca accaagggcc uagcuccauu     2520

agccagggag ugcuugagcu gucuuguccg caggcccucg agggccagca acugcuguac     2580

gucaccagag uuacagggcu uaauugcacc acaaaccacc ccaucaaucc uaagggacug     2640

gaacucgacc ccgagggcuc ccugcaucac cagcagaagc gcgaagcgcc uagccggucu     2700

uccgcuagcu cugggcccca aauucucaaa uguccugagg ccgaaugcuu cagacugcgc     2760

ugugagcuug gaccgcugca ccagcaggag ucccagagcc uccaacugca uuuuagagug     2820

ugggccaaga ccuuccugca gcgggaacac cagcccuuuu cccuucagug cgaggcugug     2880

uauaaagccc ugaagaugcc uuaccgcauc cuccccagac aacugccuca gaaagaacgg     2940

caggucgcga cggcugugca guggaccaag gccgagggca gcuauggcgu uccccucugg     3000

aucauuaucc uggccauucu uuucgggcug cuccugcugg gacuucugau cuacauucuc     3060

uacaagcugg gcuucuuuaa acgcucucuc ccguauggga cagcuaugga aaaggcccaa     3120

cugaaaccuc ccgcuaccag cgaugccuga                                      3150


<210>  1616
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B3KXM5

<400>  1616

Met Leu Ser Leu Arg Gln Arg Met Met His Ala Arg Phe Arg Asn Pro 
1               5                   10                  15      


Leu Ser Arg Gln Pro Ala Arg Pro Ser Tyr Arg Gln Gly Tyr Asn Gly 
            20                  25                  30          


Arg Pro Asn Val Glu Gly Lys Val Leu Pro Gly Ser Asn Gly Lys Pro 
        35                  40                  45              


Asn Gly Gln Arg Ile Ile Asn Gly Pro Gln Gly Thr Lys Trp Val Val 
    50                  55                  60                  


Asp Leu Asp Arg Gly Leu Val Leu Asn Ala Glu Gly Arg Tyr Leu Gln 
65                  70                  75                  80  


Asp Ser His Gly Asn Pro Leu Arg Ile Lys Leu Gly Gly Asp Gly Arg 
                85                  90                  95      


Thr Ile Val Asp Leu Glu Gly Thr Pro Val Val Ser Pro Asp Gly Leu 
            100                 105                 110         


Pro Leu Phe Gly Gln Gly Arg His Gly Thr Pro Leu Ala Asn Ala Gln 
        115                 120                 125             


Asp Lys Pro Ile Leu Ser Leu Gly Gly Lys Pro Leu Val Gly Leu Glu 
    130                 135                 140                 


Val Ile Lys Lys Thr Thr His Pro Pro Thr Thr Thr Met Gln Pro Thr 
145                 150                 155                 160 


Thr Thr Thr Thr Pro Leu Pro Thr Thr Thr Thr Pro Arg Pro Thr Thr 
                165                 170                 175     


Ala Thr Thr Arg Arg Thr Thr Thr Arg Arg Pro Thr Thr Thr Val Arg 
            180                 185                 190         


Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Pro Lys Pro Thr Thr Pro 
        195                 200                 205             


Ile Pro Thr Cys Pro Pro Gly Thr Leu Glu Arg His Asp Asp Asp Gly 
    210                 215                 220                 


Asn Leu Ile Met Ser Ser Asn Gly Ile Pro Glu Cys Tyr Ala Glu Glu 
225                 230                 235                 240 


Asp Glu Phe Ser Gly Leu Glu Thr Asp Thr Ala Val Pro Thr Glu Glu 
                245                 250                 255     


Ala Tyr Val Ile Tyr Asp Glu Asp Tyr Glu Phe Glu Thr Ser Arg Pro 
            260                 265                 270         


Pro Thr Thr Thr Glu Pro Ser Thr Thr Ala Thr Thr Pro Arg Val Ile 
        275                 280                 285             


Pro Glu Glu Gly Ala Ile Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu 
    290                 295                 300                 


Ala Gly Arg Lys Arg Phe Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys 
305                 310                 315                 320 


Asp Pro Ser Ala Pro Cys Ser Leu Thr Asp Ala Leu Asp His Phe Gln 
                325                 330                 335     


Val Asp Ser Leu Asp Glu Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp 
            340                 345                 350         


Leu Pro Pro Gln His Ala Pro Arg Asn Ile Thr Val Val Ala Val Glu 
        355                 360                 365             


Gly Cys His Ser Phe Val Ile Val Asp Trp Asp Lys Ala Thr Pro Gly 
    370                 375                 380                 


Asp Val Val Thr Gly Tyr Leu Val Tyr Ser Ala Ser Tyr Glu Asp Phe 
385                 390                 395                 400 


Ile Arg Asn Lys Trp Ser Thr Gln Ala Ser Ser Val Thr His Leu Pro 
                405                 410                 415     


Ile Glu Asn Leu Lys Pro Asn Thr Arg Tyr Tyr Phe Lys Val Gln Ala 
            420                 425                 430         


Gln Asn Pro His Gly Tyr Gly Pro Ile Ser Pro Ser Val Ser Phe Val 
        435                 440                 445             


Thr Glu Ser Asp Asn Pro Leu Leu Val Val Arg Pro Pro Gly Gly Glu 
    450                 455                 460                 


Pro Ile 
465     


<210>  1617
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG54537

<400>  1617
augcuguccu ugcgccagag gaugaugcau gccagauucc guaacccucu cucccgacag       60

ccugccagac ccucuuacag acaagguuau aauggcagac caaauguaga agggaaaguc      120

cuuccuggua guaauggaaa accgaaugga cagagaauua ucaauggccc ucaaggaaca      180

aaguggguug uggaccuuga ucguggguua guauugaaug cagaaggaag guaccuccaa      240

gauucacaug gaaauccucu ucggauuaaa cuaggaggag auggucgaac cauuguagau      300

cuggaaggga cccccguggu gaguccugac ggccucccac ucuuugggca ggggcgacau      360

ggcacaccuc uggccaaugc ccaagauaag ccaauuuuga gucuuggagg aaagccgcug      420

gugggcuugg aggucaucaa aaaaaccacc caucccccua ccacuaccau gcagcccacc      480

acuacuacga cgccccugcc uaccacuaca accccgaggc ccaccacugc caccacccgc      540

cgcacgacca ccaggcgucc aacaaccaca guccgaacca cuacgcggac aaccaccacc      600

accaccccca aacccaccac ucccaucccc accugucccc cugggaccuu ggaacggcac      660

gacgaugaug gcaaccugau aaugagcucc aaugggaucc cagagugcua cgcugaagaa      720

gaugaguucu caggcuugga gacugacacu gcaguaccua cggaagaggc cuacguuaua      780

uaugaugaag auuaugaauu ugagacguca aggccaccaa ccaccacuga gccuucgacc      840

acugcuacca caccgagggu gaucccagag gaaggcgcca ucaguuccuu uccugaagaa      900

gaauuugauc uggcuggaag gaaacgauuu guugcuccuu acgugacgua ccuaaauaaa      960

gacccaucag ccccgugcuc ucugacugau gcacuggauc acuuccaagu ggacagccug     1020

gaugaaauca uccccaauga ccugaagaag agugaccugc cuccccagca ugcuccccgc     1080

aacaucaccg ugguggccgu ggaagguugc cacucauuug ucauugugga cugggacaaa     1140

gccaccccag gagauguggu cacagguuac uugguuuaca gugcauccua ugaagacuuc     1200

aucaggaaca agugguccac ucaagcuuca ucaguaacuc acuugcccau ugagaaccua     1260

aagcccaaca cgagguauua uuuuaaagug caagcacaaa auccucaugg cuacggaccu     1320

aucagcccuu cggucucauu ugucaccgaa ucagauaauc cucugcuugu ugugaggccc     1380

ccaggcggug agccuaucua g                                               1401


<210>  1618
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG54537

<400>  1618
augcugagcc uccgccagcg gaugaugcac gcccgcuucc ggaacccccu gucccgccag       60

ccggcccggc ccagcuaccg ccagggcuac aacgggcggc ccaacgugga gggcaagguc      120

cugcccgggu ccaacggcaa gccgaacggg cagcgcauca ucaacggccc ccagggcacc      180

aagugggugg uggaccucga ccgggggcug guccugaacg cggagggccg cuaccuccag      240

gacagccacg ggaacccccu gcggaucaag cugggcgggg acggccgcac caucguggac      300

cucgagggca cgcccguggu cuccccggac gggcugcccc uguucggcca ggggcggcac      360

ggcacgcccc ucgccaacgc ccaggacaag cccauccuga gccugggcgg gaagccgcuc      420

gugggccugg aggugaucaa gaagaccacc cacccgccca ccaccaccau gcagcccacc      480

acgaccacca cgccccugcc caccaccacc acgccccgcc ccaccaccgc caccacccgg      540

cgcacgacca cccggcgccc gaccacgacc guccggacca ccacgcgcac caccaccacg      600

accaccccca agcccaccac gcccaucccg accugcccgc ccgggacccu cgagcggcac      660

gacgacgacg gcaaccugau cauguccagc aacgggaucc ccgagugcua cgccgaggag      720

gacgaguucu ccggccugga gaccgacacc gcggugccca cggaggaggc cuacgugauc      780

uacgacgagg acuacgaguu cgagaccagc cgcccgccca ccaccacgga gcccuccacc      840

accgccacca cgccccgcgu cauccccgag gagggcgcca ucagcuccuu ccccgaggag      900

gaguucgacc ucgcggggcg gaagcgcuuc guggccccgu acgugaccua ccugaacaag      960

gaccccagcg cccccugcuc ccugaccgac gcccucgacc acuuccaggu cgacagccug     1020

gacgagauca uccccaacga ccugaagaag uccgaccucc cgccccagca cgcgccccgg     1080

aacaucaccg ugguggccgu cgagggcugc cacagcuucg ugaucgugga cugggacaag     1140

gccacgcccg gggacgucgu gaccggcuac cugguguacu ccgccagcua cgaggacuuc     1200

auccgcaaca aguggagcac ccaggccucc agcgucaccc accucccgau cgagaaccug     1260

aagcccaaca cgcgguacua cuucaaggug caggcccaga acccccacgg guacggcccc     1320

aucuccccga gcgucuccuu cgugaccgag agcgacaacc cccugcuggu gguccgcccg     1380

cccggcgggg agcccaucug a                                               1401


<210>  1619
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG54537

<400>  1619
augcucuccc uccgccagcg caugaugcac gcccgcuucc gcaacccccu cucccgccag       60

cccgcccgcc ccuccuaccg ccagggcuac aacggccgcc ccaacgucga gggcaagguc      120

cuccccggcu ccaacggcaa gcccaacggc cagcgcauca ucaacggccc ccagggcacc      180

aagugggucg ucgaccucga ccgcggccuc guccucaacg ccgagggccg cuaccuccag      240

gacucccacg gcaacccccu ccgcaucaag cucggcggcg acggccgcac caucgucgac      300

cucgagggca cccccgucgu cucccccgac ggccuccccc ucuucggcca gggccgccac      360

ggcacccccc ucgccaacgc ccaggacaag cccauccucu cccucggcgg caagccccuc      420

gucggccucg aggucaucaa gaagaccacc caccccccca ccaccaccau gcagcccacc      480

accaccacca ccccccuccc caccaccacc accccccgcc ccaccaccgc caccacccgc      540

cgcaccacca cccgccgccc caccaccacc guccgcacca ccacccgcac caccaccacc      600

accaccccca agcccaccac ccccaucccc accugccccc ccggcacccu cgagcgccac      660

gacgacgacg gcaaccucau cauguccucc aacggcaucc ccgagugcua cgccgaggag      720

gacgaguucu ccggccucga gaccgacacc gccgucccca ccgaggaggc cuacgucauc      780

uacgacgagg acuacgaguu cgagaccucc cgccccccca ccaccaccga gcccuccacc      840

accgccacca ccccccgcgu cauccccgag gagggcgcca ucuccuccuu ccccgaggag      900

gaguucgacc ucgccggccg caagcgcuuc gucgcccccu acgucaccua ccucaacaag      960

gaccccuccg cccccugcuc ccucaccgac gcccucgacc acuuccaggu cgacucccuc     1020

gacgagauca uccccaacga ccucaagaag uccgaccucc ccccccagca cgccccccgc     1080

aacaucaccg ucgucgccgu cgagggcugc cacuccuucg ucaucgucga cugggacaag     1140

gccacccccg gcgacgucgu caccggcuac cucgucuacu ccgccuccua cgaggacuuc     1200

auccgcaaca agugguccac ccaggccucc uccgucaccc accuccccau cgagaaccuc     1260

aagcccaaca cccgcuacua cuucaagguc caggcccaga acccccacgg cuacggcccc     1320

aucucccccu ccgucuccuu cgucaccgag uccgacaacc cccuccucgu cguccgcccc     1380

cccggcggcg agcccaucug a                                               1401


<210>  1620
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG54537

<400>  1620
augcugagcc ucagacagag gaugaugcac gcccgguucc gcaacccccu uucccgacaa       60

ccugcucguc caucuuacag acagggcuau aaugggaggc cgaacgugga gggaaagguc      120

cugcccgguu caaauggcaa accuaacggg cagcggauca uuaauggacc acagggcacc      180

aaguggguug uggacuugga ucgcgguuua guacugaacg cagaagggag auaccuacaa      240

gacagucaug gaaauccccu caggauaaaa cugggcggcg augggcggac aaucguggac      300

cuugagggaa cuccugucgu gagcccagau ggucugcccu uguuuggcca ggggcgccac      360

ggaacgccuc ucgccaacgc gcaggacaag ccaauucugu cccugggcgg uaaaccgcuc      420

guuggguuag aagugaucaa gaagaccaca caucccccua cuaccacaau gcagccaacc      480

acuacaacca cgccccugcc uacuaccaca acuccacgac ccaccacagc uaccacgaga      540

aggacuacaa cccggcgucc gacuacaacc guccgcacga ccacaagaac uaccacaacu      600

accacaccua aacccaccac uccaauuccu acgugucccc caggaacacu ugagaggcac      660

gaugacgaug gcaauuugau caugucuucg aacggcauac ccgaaugcua ugccgaggag      720

gacgaguucu cagggcugga aaccgauacu gcagugccua ccgaagaggc cuacguaauc      780

uaugacgagg auuacgaauu ugagacaagc cggccaccga ccacuacaga acccaguacg      840

accgcuacua caccucgagu uauuccagag gaaggagcaa ucuccucuuu ccccgaggag      900

gaauuugacc uagccggucg caagagauuc guggcuccuu augucaccua ccucaauaaa      960

gacccaagcg cccccugcuc ccugacagau gcgcuugacc auuuucaagu ggauucacug     1020

gacgagauua ucccgaacga uuugaagaaa agugaccucc cuccacagca cgcacccagg     1080

aauauaacug uggucgccgu ugaaggcugu cacagcuucg ugauuguaga uugggacaag     1140

gcuaccccug gggauguggu cacgggauac cugguguauu cugccuccua cgaggacuuu     1200

auccggaaca aguggucaac ccaggcaagc aguguuacac auuuacccau ugaaaaucug     1260

aaaccaaaca cucgcuauua cuucaaggug caggcucaaa acccucacgg cuaugguccc     1320

aucucuccau ccgucagcuu ugugaccgag ucggauaauc cgcuccuugu aguuagaccu     1380

cccgggggcg agccaaucug a                                               1401


<210>  1621
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG54537

<400>  1621
augcugagcc ugagacagag aaugaugcac gccagauuca gaaacccccu gagcagacag       60

cccgccagac ccagcuacag acagggcuac aacggcagac ccaacgugga gggcaaggug      120

cugcccggca gcaacggcaa gcccaacggc cagagaauca ucaacggccc ccagggcacc      180

aagugggugg uggaccugga cagaggccug gugcugaacg ccgagggcag auaccugcag      240

gacagccacg gcaacccccu gagaaucaag cugggcggcg acggcagaac caucguggac      300

cuggagggca cccccguggu gagccccgac ggccugcccc uguucggcca gggcagacac      360

ggcacccccc uggccaacgc ccaggacaag cccauccuga gccugggcgg caagccccug      420

gugggccugg aggugaucaa gaagaccacc caccccccca ccaccaccau gcagcccacc      480

accaccacca ccccccugcc caccaccacc acccccagac ccaccaccgc caccaccaga      540

agaaccacca ccagaagacc caccaccacc gugagaacca ccaccagaac caccaccacc      600

accaccccca agcccaccac ccccaucccc accugccccc ccggcacccu ggagagacac      660

gacgacgacg gcaaccugau caugagcagc aacggcaucc ccgagugcua cgccgaggag      720

gacgaguuca gcggccugga gaccgacacc gccgugccca ccgaggaggc cuacgugauc      780

uacgacgagg acuacgaguu cgagaccagc agacccccca ccaccaccga gcccagcacc      840

accgccacca cccccagagu gauccccgag gagggcgcca ucagcagcuu ccccgaggag      900

gaguucgacc uggccggcag aaagagauuc guggcccccu acgugaccua ccugaacaag      960

gaccccagcg cccccugcag ccugaccgac gcccuggacc acuuccaggu ggacagccug     1020

gacgagauca uccccaacga ccugaagaag agcgaccugc ccccccagca cgcccccaga     1080

aacaucaccg ugguggccgu ggagggcugc cacagcuucg ugaucgugga cugggacaag     1140

gccacccccg gcgacguggu gaccggcuac cugguguaca gcgccagcua cgaggacuuc     1200

aucagaaaca aguggagcac ccaggccagc agcgugaccc accugcccau cgagaaccug     1260

aagcccaaca ccagauacua cuucaaggug caggcccaga acccccacgg cuacggcccc     1320

aucagcccca gcgugagcuu cgugaccgag agcgacaacc cccugcuggu ggugagaccc     1380

cccggcggcg agcccaucug a                                               1401


<210>  1622
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG54537

<400>  1622
augcugagcc ucagacagcg gaugaugcac gcccgcuuca gaaacccccu gucccggcaa       60

ccugcucgcc cgucuuacag acagggcuau aaugggcggc ccaacgugga gggaaagguc      120

cuuccuggca gcaaugggaa acccaacgga cagcgcauca uuaauggccc ucaggggacc      180

aaguggguug uggaccugga uagaggacuc gugcugaacg ccgaaggccg guaccuucaa      240

gacucccaug gcaauccccu gcgcaucaaa cucgggggag auggcagaac aauugucgac      300

cuggagggga cgccuguggu uucuccggau ggacugcccc ucuuuggcca ggggcggcac      360

ggaaccccuc uggcgaacgc ucaggacaag cccauccuua gccugggcgg caaaccucuc      420

guggggcugg aagucauuaa gaagacaacc caucccccga caaccacaau gcagccuacc      480

acgaccacaa caccccuucc uaccaccacg acaccccgcc ccaccacagc caccaccaga      540

cggacaacga cccgcagacc uacaaccaca gugcggacca cgacaagaac caccacaacc      600

acaacgccga aacccaccac accuaucccc acaugcccuc ccggaacccu ggagcgccac      660

gaugacgaug gcaaucucau cauguccucu aacgggauuc cggaauguua ugccgaggag      720

gacgaguuca gcggacugga aaccgauacg gcuguuccua ccgaagaggc cuacgugauc      780

uaugacgagg auuacgaauu ugagacaucc cggcccccua ccacaaccga acccagcacg      840

acagcuacca caccuagagu cauucccgag gaaggcgcca ucucuuccuu cccggaggag      900

gaauuugacc uggcggggcg caagcgguuc guggccccuu augugaccua ccucaauaaa      960

gaccccagcg cucccugcuc ucugaccgau gcccuugacc auuuucaagu cgauucccug     1020

gacgagauua ucccuaacga ucucaagaaa agcgaccugc cgccccagca cgcuccuaga     1080

aauauuacag uuguggccgu ggaaggaugu cacucuuucg ucaucgugga uugggacaag     1140

gcgacgcccg gcgauguugu gaccggcuac cuugucuauu ccgccagcua cgaggacuuu     1200

auccgcaaca agugguccac acaggcuucu agcgugaccc aucugccuau ugaaaaucuc     1260

aaacccaaca cacgguauua cuucaagguu caggcccaaa acccucacgg guauggaccc     1320

aucuccccga gcgugucuuu ugucaccgag uccgauaauc cucugcuggu ggucagaccc     1380

ccuggcgggg agcccauuug a                                               1401


<210>  1623
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DIC5

<400>  1623

Met Glu Glu Gln Arg Asn Glu Glu Ile Gln Ser Phe Ile Tyr Ser Leu 
1               5                   10                  15      


Lys Gln Met Leu Leu Asn Val Glu Ala Asn Ser Ala Lys Val Gln Glu 
            20                  25                  30          


Asp Leu Glu Ala Glu Phe Gln Ser Leu Phe Ser Leu Leu Glu Glu Leu 
        35                  40                  45              


Lys Glu Gly Met Leu Met Lys Ile Lys Gln Asp Arg Ala Ser Arg Thr 
    50                  55                  60                  


Tyr Glu Leu Gln Asn Gln Leu Ala Ala Cys Thr Arg Ala Leu Glu Ser 
65                  70                  75                  80  


Ser Glu Glu Leu Leu Glu Thr Ala Asn Gln Thr Leu Gln Ala Met Asp 
                85                  90                  95      


Ser Glu Asp Phe Pro Gln Ala Ala Lys Gln Ile Lys Asp Gly Val Thr 
            100                 105                 110         


Met Ala Pro Ala Phe Arg Leu Ser Leu Lys Ala Lys Val Ser Asp Asn 
        115                 120                 125             


Met Ser His Leu Met Val Asp Phe Ala Gln Glu Arg Gln Met Leu Gln 
    130                 135                 140                 


Ala Leu Lys Phe Leu Pro Gly Glu Arg Gly Thr His 
145                 150                 155     


<210>  1624
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG58437

<400>  1624
auggaagaac agaggaauga agaaauucag agcuuuaucu acucccugaa acagaugcug       60

cugaacgugg aggcgaacuc ggcgaaggug caggaggacc ucgaagcaga guuccagucc      120

cucuucuccc uccuggagga gcugaaagaa ggcaugcuua ugaagauaaa acaggaccgu      180

gccagccgca ccuacgagcu gcagaaccag cuggcugccu gcacgcgggc ccuggagagc      240

uccgaggagc uucuggagac agccaaccag acucugcagg ccauggacag cgaggacuuu      300

ccucaggcug ccaagcaaau caaagaugga gugaccaugg ccccugccuu ccggcuauca      360

uugaaagcga aggucaguga caacaugagu caccucaugg uggacuucgc gcaagagcgg      420

cagaugcuac aggcacucaa guuccugccu ggugagaggg gcacgcacua g               471


<210>  1625
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG58437

<400>  1625
auggaggagc agcgcaacga ggagauccag agcuucaucu acucccugaa gcagaugcuc       60

cugaacgugg aggccaacag cgccaagguc caggaggacc uggaggcgga guuccagucc      120

cucuucagcc ugcuggagga gcucaaggag ggcaugcuga ugaagaucaa gcaggaccgg      180

gccucccgca ccuacgagcu gcagaaccag cucgccgccu gcacccgggc ccuggagagc      240

uccgaggagc ugcucgagac ggcgaaccag acccugcagg ccauggacag cgaggacuuc      300

ccccaggccg ccaagcagau caaggacggg gugaccaugg cgccggccuu ccgccugucc      360

cucaaggcca aggugagcga caacaugucc caccugaugg ucgacuucgc ccaggagcgg      420

cagaugcugc aggcccucaa guuccugccc ggcgagcgcg ggacccacug a               471


<210>  1626
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG58437

<400>  1626
auggaggagc agcgcaacga ggagauccag uccuucaucu acucccucaa gcagaugcuc       60

cucaacgucg aggccaacuc cgccaagguc caggaggacc ucgaggccga guuccagucc      120

cucuucuccc uccucgagga gcucaaggag ggcaugcuca ugaagaucaa gcaggaccgc      180

gccucccgca ccuacgagcu ccagaaccag cucgccgccu gcacccgcgc ccucgagucc      240

uccgaggagc uccucgagac cgccaaccag acccuccagg ccauggacuc cgaggacuuc      300

ccccaggccg ccaagcagau caaggacggc gucaccaugg cccccgccuu ccgccucucc      360

cucaaggcca aggucuccga caacaugucc caccucaugg ucgacuucgc ccaggagcgc      420

cagaugcucc aggcccucaa guuccucccc ggcgagcgcg gcacccacug a               471


<210>  1627
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG58437

<400>  1627
auggaggaac agagaaacga ggaaauccag agcuucauuu acucccugaa gcaaaugcuc       60

cuuaaugugg aggccaacuc ugcuaaaguc caggaagacc uggaggcaga guuucaguca      120

uuguucaguu uacuggagga acuaaaggaa ggcaugcuca ugaaaauaaa gcaagauagg      180

gccagccgga ccuaugagcu gcagaaucag cuugcggcuu gcacacgcgc ccuggagucc      240

ucugaagagu ugcucgaaac ugcaaaccag acgcugcaag ccauggacuc ggaggauuuu      300

ccccaggcug caaaacagau caaggacggg guuaccaugg ccccugcuuu ccgacuguca      360

cucaaggcca aagugagcga uaauaugagu cacuuaaugg uagacuuugc gcaggaacgu      420

caaaugcugc aggcacuuaa guucuugcca ggagagagag guacacauug a               471


<210>  1628
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG58437

<400>  1628
auggaggagc agagaaacga ggagauccag agcuucaucu acagccugaa gcagaugcug       60

cugaacgugg aggccaacag cgccaaggug caggaggacc uggaggccga guuccagagc      120

cuguucagcc ugcuggagga gcugaaggag ggcaugcuga ugaagaucaa gcaggacaga      180

gccagcagaa ccuacgagcu gcagaaccag cuggccgccu gcaccagagc ccuggagagc      240

agcgaggagc ugcuggagac cgccaaccag acccugcagg ccauggacag cgaggacuuc      300

ccccaggccg ccaagcagau caaggacggc gugaccaugg cccccgccuu cagacugagc      360

cugaaggcca aggugagcga caacaugagc caccugaugg uggacuucgc ccaggagaga      420

cagaugcugc aggcccugaa guuccugccc ggcgagagag gcacccacug a               471


<210>  1629
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG58437

<400>  1629
auggaggaac agagaaacga ggaaauccag agcuucauuu acucccugaa gcaaaugcuc       60

cugaaugugg aggccaacuc ugcuaaaguc caggaagacc uugaggccga guuucagagc      120

cuguucuccc uccuggaaga acuuaaggaa ggcaugcuga ugaaaaucaa gcaagaucgg      180

gcgucucgca ccuaugagcu ccagaaucag cuggcugccu gcacaagagc ccuggagagc      240

uccgaggagc uccuggaaac ggcuaaccag acccuucaag ccauggacuc ugaggauuuu      300

ccccaggcug ccaaacagau uaaggacggg guuacaaugg cgccugccuu ccggcugagc      360

cucaaggcua aaguguccga uaauaugagc caccugaugg uggacuuugc ccaggaacgc      420

caaaugcuuc aggcucugaa guuccucccg ggagagagag gcacccauug a               471


<210>  1630
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DN21

<400>  1630

Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr 
1               5                   10                  15      


Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly 
            20                  25                  30          


Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp 
        35                  40                  45              


Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu 
    50                  55                  60                  


Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr 
65                  70                  75                  80  


Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys 
                85                  90                  95      


Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn 
            100                 105                 110         


Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp 
        115                 120                 125             


Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met 
    130                 135                 140                 


Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser 
145                 150                 155                 160 


Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val 
                165                 170                 175     


Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln 
            180                 185                 190         


Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys 
        195                 200                 205             


Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val 
    210                 215                 220                 


Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr 
225                 230                 235                 240 


Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro 
                245                 250                 255     


Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln 
            260                 265                 270         


Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro 
        275                 280                 285             


Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser 
    290                 295                 300                 


Arg Glu 
305     


<210>  1631
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAH14721

<400>  1631
augaucuuug aggaacaugg uuuuaggcgg accacaccgc ccacaacggc cacccccaua       60

aggcauaggc caagaccaua cccgccgaau guaggacaag aagcucucuc ucagacaacc      120

aucucauggg ccccauucca ggacacuucu gaguacauca uuucauguca uccuguuggc      180

acugaugaag aacccuuaca guucaggguu ccuggaacuu cuaccagugc cacucugaca      240

ggccucacca gaggugccac cuacaacauc auaguggagg cacugaaaga ccagcagagg      300

cauaagguuc gggaagaggu uguuaccgug ggcaacucug ucaacgaagg cuugaaccaa      360

ccuacggaug acucgugcuu ugaccccuac acaguuuccc auuaugccgu uggagaugag      420

ugggaacgaa ugucugaauc aggcuuuaaa cuguugugcc agugcuuagg cuuuggaagu      480

ggucauuuca gaugugauuc aucuagaugg ugccaugaca auggugugaa cuacaagauu      540

ggagagaagu gggaccguca gggagaaaau ggccagauga ugagcugcac augucuuggg      600

aacggaaaag gagaauucaa gugugacccu caugaggcaa cguguuauga ugaugggaag      660

acauaccacg uaggagaaca guggcagaag gaauaucucg gugccauuug cuccugcaca      720

ugcuuuggag gccagcgggg cuggcgcugu gacaacugcc gcagaccugg gggugaaccc      780

agucccgaag gcacuacugg ccaguccuac aaccaguauu cucagagaua ccaucagaga      840

acaaacacua auguuaauug cccaauugag ugcuucaugc cuuuagaugu acaggcugac      900

agagaagauu cccgagagua a                                                921


<210>  1632
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAH14721

<400>  1632
augaucuucg aggagcacgg cuuccgccgg accacgcccc cgaccaccgc cacccccauc       60

cgccaccggc cccgccccua cccgcccaac guggggcagg aggcccugag ccagaccacg      120

aucuccuggg cgcccuucca ggacaccagc gaguacauca ucuccugcca ccccgucggc      180

accgacgagg agccgcucca guuccgggug cccgggacca gcacguccgc cacccugacc      240

ggccugaccc gcggggccac guacaacauc aucguggagg cccucaagga ccagcagcgg      300

cacaaggucc gcgaggaggu ggugaccguc ggcaacagcg ugaacgaggg ccugaaccag      360

cccaccgacg acuccugcuu cgaccccuac accgugagcc acuacgccgu cggggacgag      420

ugggagcgga uguccgagag cggcuucaag cugcucugcc agugccuggg guucggcucc      480

gggcacuucc gcugcgacag cucccggugg ugccacgaca acggcgugaa cuacaagauc      540

ggcgagaagu gggaccgcca gggggagaac ggccagauga ugagcugcac gugccugggg      600

aacggcaagg gcgaguucaa gugcgacccg cacgaggcga ccugcuacga cgacgggaag      660

accuaccacg ugggcgagca guggcagaag gaguaccucg gggccaucug cuccugcacg      720

ugcuucggcg ggcagcgggg cuggcgcugc gacaacugcc ggcgccccgg cggggagccc      780

agccccgagg gcaccaccgg gcaguccuac aaccaguaca gccagcggua ccaccagcgc      840

accaacacca acgucaacug cccgaucgag ugcuucaugc cccuggacgu gcaggccgac      900

cgggaggacu cccgcgagug a                                                921


<210>  1633
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAH14721

<400>  1633
augaucuucg aggagcacgg cuuccgccgc accacccccc ccaccaccgc cacccccauc       60

cgccaccgcc cccgccccua cccccccaac gucggccagg aggcccucuc ccagaccacc      120

aucuccuggg cccccuucca ggacaccucc gaguacauca ucuccugcca ccccgucggc      180

accgacgagg agccccucca guuccgcguc cccggcaccu ccaccuccgc cacccucacc      240

ggccucaccc gcggcgccac cuacaacauc aucgucgagg cccucaagga ccagcagcgc      300

cacaaggucc gcgaggaggu cgucaccguc ggcaacuccg ucaacgaggg ccucaaccag      360

cccaccgacg acuccugcuu cgaccccuac accgucuccc acuacgccgu cggcgacgag      420

ugggagcgca uguccgaguc cggcuucaag cuccucugcc agugccucgg cuucggcucc      480

ggccacuucc gcugcgacuc cucccgcugg ugccacgaca acggcgucaa cuacaagauc      540

ggcgagaagu gggaccgcca gggcgagaac ggccagauga uguccugcac cugccucggc      600

aacggcaagg gcgaguucaa gugcgacccc cacgaggcca ccugcuacga cgacggcaag      660

accuaccacg ucggcgagca guggcagaag gaguaccucg gcgccaucug cuccugcacc      720

ugcuucggcg gccagcgcgg cuggcgcugc gacaacugcc gccgccccgg cggcgagccc      780

ucccccgagg gcaccaccgg ccaguccuac aaccaguacu cccagcgcua ccaccagcgc      840

accaacacca acgucaacug ccccaucgag ugcuucaugc cccucgacgu ccaggccgac      900

cgcgaggacu cccgcgagug a                                                921


<210>  1634
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAH14721

<400>  1634
augaucuucg aggaacacgg cuuuagaagg accacacccc cuacuacggc caccccaauu       60

cggcaucgcc cgcgacccua cccuccaaac guggggcagg aggcucugag ccaaacaacu      120

auauccuggg cacccuucca ggacaccucu gaauauauca uuucaugcca cccugucgga      180

acagaugagg aaccacucca guuucguguu cccgguacca guacuagcgc cacacuuacc      240

ggccugacga gaggggcgac uuacaauauc auuguggagg cuuugaagga ccagcaaagg      300

cauaaaguac gggaggaagu ggucaccgug ggaaacuccg uuaaugaggg cuuaaaccag      360

ccuacagaug acucuuguuu cgauccauau acugugucgc acuacgccgu cggugacgaa      420

ugggagcgca ugucagagag cggguuuaag cugcuaugcc agugucucgg auucggcagu      480

ggccauuuua gaugcgauuc cucuaggugg ugucacgaca auggggugaa cuauaaaauc      540

ggagaaaagu gggaucggca gggugagaau ggccaaauga ugagcugcac cugucugggg      600

aacggaaaag gcgaguucaa gugcgacccg cacgaagcaa cauguuacga ugacgguaag      660

accuaucaug uaggggaaca guggcagaaa gaguaccuug gagccauaug cuccuguacg      720

ugcuuuggcg gccagcgcgg guggcgaugc gauaauugua gaaggcccgg aggugagccu      780

ucaccagaag gcacuacagg gcaaaguuac aaccaguaua gccagcggua ccaccaacgu      840

accaauacua acguuaauug ccccaucgag uguuucaugc cucuggacgu gcaggcugac      900

cgcgaagauu cuagagagug a                                                921


<210>  1635
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAH14721

<400>  1635
augaucuucg aggagcacgg cuucagaaga accacccccc ccaccaccgc cacccccauc       60

agacacagac ccagacccua cccccccaac gugggccagg aggcccugag ccagaccacc      120

aucagcuggg cccccuucca ggacaccagc gaguacauca ucagcugcca ccccgugggc      180

accgacgagg agccccugca guucagagug cccggcacca gcaccagcgc cacccugacc      240

ggccugacca gaggcgccac cuacaacauc aucguggagg cccugaagga ccagcagaga      300

cacaagguga gagaggaggu ggugaccgug ggcaacagcg ugaacgaggg ccugaaccag      360

cccaccgacg acagcugcuu cgaccccuac accgugagcc acuacgccgu gggcgacgag      420

ugggagagaa ugagcgagag cggcuucaag cugcugugcc agugccuggg cuucggcagc      480

ggccacuuca gaugcgacag cagcagaugg ugccacgaca acggcgugaa cuacaagauc      540

ggcgagaagu gggacagaca gggcgagaac ggccagauga ugagcugcac cugccugggc      600

aacggcaagg gcgaguucaa gugcgacccc cacgaggcca ccugcuacga cgacggcaag      660

accuaccacg ugggcgagca guggcagaag gaguaccugg gcgccaucug cagcugcacc      720

ugcuucggcg gccagagagg cuggagaugc gacaacugca gaagacccgg cggcgagccc      780

agccccgagg gcaccaccgg ccagagcuac aaccaguaca gccagagaua ccaccagaga      840

accaacacca acgugaacug ccccaucgag ugcuucaugc cccuggacgu gcaggccgac      900

agagaggaca gcagagagug a                                                921


<210>  1636
<211>  921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAH14721

<400>  1636
augaucuucg aggaacacgg cuuuagacgg accacacccc cuacgaccgc cacaccgauu       60

cgccauagac cccggccuua ucccccuaac guggggcagg aggcucugag ccaaaccaca      120

aucuccuggg cccccuucca ggacaccucu gaauacauua ucagcugcca cccugucgga      180

acagaugagg aaccgcucca guuucgcguu cccggcaccu ccacgucugc gacccugaca      240

gggcuuacca gaggagcuac auacaauauu aucguggagg cccugaagga ccagcaacgg      300

cauaaagugc gcgaggaagu cgugaccguu ggcaacagcg ugaaugaggg gcucaaccag      360

ccuacggaug acuccuguuu cgaucccuau acagucucuc acuacgccgu gggagacgaa      420

ugggagagaa ugagcgaguc cggcuuuaag cugcuuugcc agugucuggg cuucgggagc      480

ggacauuuuc ggugcgauuc uucccgcugg ugucacgaca auggcguuaa cuauaaaauc      540

ggggaaaagu gggauagaca gggagagaau ggccaaauga ugagcugcac cugucucggg      600

aacggaaaag gcgaguucaa gugcgacccu cacgaagcua cauguuacga ugacggcaag      660

accuaucaug ugggggaaca guggcagaaa gaguaccugg gagccauuug cucuuguacc      720

ugcuuuggcg ggcagcgggg auggcgcugc gauaauugua gacggcccgg cggggagccg      780

uccccugaag gaacaacggg ccaaagcuac aaccaguauu cucagcgcua ccaccaaaga      840

accaauacaa acgucaauug ccccaucgag uguuucaugc cucuggacgu gcaggcugac      900

cgggaagauu ccagagagug a                                                921


<210>  1637
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DS98

<400>  1637

Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys 
1               5                   10                  15      


Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn 
            20                  25                  30          


Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn 
        35                  40                  45              


Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr 
    50                  55                  60                  


Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu 
65                  70                  75                  80  


Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala 
                85                  90                  95      


Asp Leu Arg Asn Leu Arg Ser Leu His Leu Asn Ser Asn Arg Leu Thr 
            100                 105                 110         


Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu 
        115                 120                 125             


Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp 
    130                 135                 140                 


Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu 
145                 150                 155                 160 


Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu 
                165                 170                 175     


Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser 
            180                 185                 190         


His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln 
        195                 200                 205             


Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr 
    210                 215                 220                 


Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn 
225                 230                 235                 240 


Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg 
                245                 250                 255     


Glu Tyr Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg 
            260                 265                 270         


Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu 
        275                 280                 285             


Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala 
    290                 295                 300                 


Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp 
305                 310                 315                 320 


Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val 
                325                 330                 335     


Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr 
            340                 345                 350         


Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln 
        355                 360                 365             


Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr 
    370                 375                 380                 


Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser 
385                 390                 395                 400 


Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Asp Gly Ile Thr Ser 
                405                 410                 415     


Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln 
            420                 425                 430         


Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr 
        435                 440                 445             


Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe 
    450                 455                 460                 


Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln 
465                 470                 475                 480 


His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala 
                485                 490                 495     


Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln 
            500                 505                 510         


Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp 
        515                 520                 525             


Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ala Thr 
    530                 535                 540                 


Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser 
545                 550                 555                 560 


Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln 
                565                 570                 575     


Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn 
            580                 585                 590         


Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu 
        595                 600                 605             


Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr 
    610                 615                 620                 


Asn Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile 
625                 630                 635                 


<210>  1638
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG61560

<400>  1638
auggaaaaaa uucuuuuuua ucuguuucuc auuggcauag cagugaaagc ucagaucugu       60

ccaaagcguu gugucuguca gauuuugucu ccuaaucuug caacccuuug ugccaagaaa      120

gggcuuuuau uuguuccacc aaacauugac agaagaacug uggaacugcg guuggcagac      180

aauuuuguua caaauauuaa aaggaaagau uuugccaaua ugaccagcuu gguggaccug      240

acucuaucca ggaauacaau aaguuuuauu acaccucaug cuuucgcuga ccuacgaaau      300

uugaggucuu ugcauuugaa uagcaacaga uugacuaaaa uuacaaauga uauguucagu      360

ggucuuucca aucuucauca uuugauacug aacaacaauc agcugacuuu aauuuccucu      420

acagcguuug augaugucuu cgcccuugag gagcuggauc uguccuauaa uaaucuagaa      480

accauuccuu gggaugcugu ugagaagaug guuagcuugc auacccuuag uuuggaucac      540

aauaugauug auaacauucc uaaggggacc uucucccauu ugcacaagau gacucgguua      600

gaugugacau caaauaaauu gcagaagcua ccaccugacc cucucuuuca gcgagcucag      660

guacuagcaa ccucaggaau cauaagccca ucuacuuuug cauuaaguuu ugguggaaac      720

cccuugcauu gcaauuguga auuguugugg uugaggcguc uguccagaga auaugacuua      780

gagaccugug cuucuccucc acuuuuaacu ggccgcuacu uuuggucaau uccugaagaa      840

gaguuuuugu gugagccucc ucucauuacu cgucauacac augagaugag aguccuggag      900

ggacaaaggg caacacugag gugcaaagcc aggggagacc cugagccugc aauucacugg      960

auuucuccug aagggaagcu uauuucaaau gcaacaagau cucuggugua ugauaacgga     1020

acacuugaca uucuuaucac aacuguaaag gauacaggug cuuuuaccug cauugcuucc     1080

aauccugcug gggaagcaac acaaauagug gaucuucaua uaauuaagcu cccucacuua     1140

cuaaauagua caaaccauau ccaugagccu gauccugguu cuucagauau cucaacuucu     1200

accaagucag guucuaauac aagcaguagu aaugauggca ucacuucccu cacugccaca     1260

agagucgugg guugcaucca guuuacuacg gaacaggauu augugcguug ccauuucaug     1320

cagucccagu uuuugggagg caccaugauu auuauuauug guggaaucau uguagcaucu     1380

gugcugguau ucaucauuau ucugaugauc cgguauaagg uuugcaacaa uaaugggcaa     1440

cacaagguca ccaagguuag caauguuuau ucccaaacua acggggcuca aauacaaggc     1500

uguaguguaa cgcugcccca guccgugucc aaacaagcug ugggacacga agagaaugcc     1560

caguguugua aagcuaccag ugacaaugug auucaaucuu cagaaacuug uucgagucag     1620

gacuccgcua ccacuaccuc ugcuuugccu ccuuccugga cuucaagcac uucugugucc     1680

caaaagcaga aaagaaagac uggcacaaag ccaaguacag aaccacagaa ugaagccguc     1740

acaaauguug aaucccaaaa cacuaacagg aacaacucaa cugccuugca guuagcuagc     1800

cguccucccg auucugucac agaggggccc acgucuaaaa gagcacauau aaagccaaau     1860

gcuuugcuga cuaauguuga ccagauuguc caggaaacac agaggcugga guuaaucuga     1920


<210>  1639
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG61560

<400>  1639
auggagaaga uccuguucua ccucuuccug aucggcaucg ccgugaaggc ccagaucugc       60

cccaagcgcu gcgucugcca gauccugagc ccgaaccucg cgacccugug cgccaagaag      120

gggcuccugu ucgugccgcc caacaucgac cggcgcaccg uggagcugcg gcuggccgac      180

aacuucguca cgaacaucaa gcgcaaggac uucgccaaca ugaccucccu cguggaccug      240

acccugagcc ggaacaccau cuccuucauc acgccccacg ccuucgcgga ccuccgcaac      300

cugcggagcc ugcaccucaa cuccaaccgc cugaccaaga ucaccaacga cauguucagc      360

ggccugucca accuccacca ccugauccug aacaacaacc agcucacccu gaucagcucc      420

acggccuucg acgacguguu cgcccuggag gagcucgacc ugagcuacaa caaccuggag      480

accauccccu gggacgccgu cgagaagaug gugucccucc acacccugag ccuggaccac      540

aacaugaucg acaacauccc caaggggacc uucucccacc uccacaagau gacgcggcug      600

gacgugacca gcaacaagcu gcagaagcuc ccgcccgacc cccuguucca gcgcgcgcag      660

guccuggcca ccuccggcau caucagcccc uccaccuucg cccucagcuu cgggggcaac      720

ccccugcacu gcaacugcga gcugcucugg cugcggcgcc ugucccggga guacgaccuc      780

gagacgugcg ccagcccgcc ccugcugacc ggccgcuacu ucuggagcau ccccgaggag      840

gaguuccucu gcgagccgcc ccugaucacc cggcacaccc acgagaugcg cgugcuggag      900

gggcagcggg ccacgcuccg cugcaaggcg cggggcgacc ccgagcccgc cauccacugg      960

aucucccccg aggggaagcu gaucagcaac gccacccgcu cccuggugua cgacaacggc     1020

acccuggaca uccucaucac cacggucaag gacaccgggg ccuucacgug caucgccagc     1080

aaccccgcgg gcgaggccac ccagaucgug gaccugcaca ucaucaagcu gccgcaccuc     1140

cugaacucca ccaaccacau ccacgagccc gaccccggca gcuccgacau cagcaccucc     1200

accaagagcg gguccaacac cagcuccagc aacgacggca ucacgucccu gaccgccacc     1260

cggguggucg ggugcaucca guucaccacg gagcaggacu acgugcgcug ccacuucaug     1320

cagagccagu uccucggcgg caccaugauc aucaucaucg ggggcaucau cguggccucc     1380

guccuggugu ucaucaucau ccugaugauc cgcuacaagg ugugcaacaa caacgggcag     1440

cacaagguca ccaaggugag caacguguac ucccagacca acggcgccca gauccagggg     1500

ugcagcguca cccuccccca gagcgugucc aagcaggcgg ucggccacga ggagaacgcc     1560

cagugcugca aggccacgag cgacaacgug auccagucca gcgagaccug cuccagccag     1620

gacuccgcca ccaccacgag cgcccugccg cccuccugga ccagcuccac cagcgugucc     1680

cagaagcaga agcggaagac cggcacgaag cccagcaccg agccccagaa cgaggcgguc     1740

accaacgugg agucccagaa caccaaccgc aacaacagca cggcccugca gcucgccucc     1800

cggccgcccg acagcgugac cgaggggccc accagcaagc gcgcccacau caagccgaac     1860

gcgcugcuga ccaacgucga ccagaucgug caggagacgc agcggcucga gcugaucuga     1920


<210>  1640
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG61560

<400>  1640
auggagaaga uccucuucua ccucuuccuc aucggcaucg ccgucaaggc ccagaucugc       60

cccaagcgcu gcgucugcca gauccucucc cccaaccucg ccacccucug cgccaagaag      120

ggccuccucu ucgucccccc caacaucgac cgccgcaccg ucgagcuccg ccucgccgac      180

aacuucguca ccaacaucaa gcgcaaggac uucgccaaca ugaccucccu cgucgaccuc      240

acccucuccc gcaacaccau cuccuucauc accccccacg ccuucgccga ccuccgcaac      300

cuccgcuccc uccaccucaa cuccaaccgc cucaccaaga ucaccaacga cauguucucc      360

ggccucucca accuccacca ccucauccuc aacaacaacc agcucacccu caucuccucc      420

accgccuucg acgacgucuu cgcccucgag gagcucgacc ucuccuacaa caaccucgag      480

accauccccu gggacgccgu cgagaagaug gucucccucc acacccucuc ccucgaccac      540

aacaugaucg acaacauccc caagggcacc uucucccacc uccacaagau gacccgccuc      600

gacgucaccu ccaacaagcu ccagaagcuc ccccccgacc cccucuucca gcgcgcccag      660

guccucgcca ccuccggcau caucuccccc uccaccuucg cccucuccuu cggcggcaac      720

ccccuccacu gcaacugcga gcuccucugg cuccgccgcc ucucccgcga guacgaccuc      780

gagaccugcg ccuccccccc ccuccucacc ggccgcuacu ucugguccau ccccgaggag      840

gaguuccucu gcgagccccc ccucaucacc cgccacaccc acgagaugcg cguccucgag      900

ggccagcgcg ccacccuccg cugcaaggcc cgcggcgacc ccgagcccgc cauccacugg      960

aucucccccg agggcaagcu caucuccaac gccacccgcu cccucgucua cgacaacggc     1020

acccucgaca uccucaucac caccgucaag gacaccggcg ccuucaccug caucgccucc     1080

aaccccgccg gcgaggccac ccagaucguc gaccuccaca ucaucaagcu cccccaccuc     1140

cucaacucca ccaaccacau ccacgagccc gaccccggcu ccuccgacau cuccaccucc     1200

accaaguccg gcuccaacac cuccuccucc aacgacggca ucaccucccu caccgccacc     1260

cgcgucgucg gcugcaucca guucaccacc gagcaggacu acguccgcug ccacuucaug     1320

cagucccagu uccucggcgg caccaugauc aucaucaucg gcggcaucau cgucgccucc     1380

guccucgucu ucaucaucau ccucaugauc cgcuacaagg ucugcaacaa caacggccag     1440

cacaagguca ccaaggucuc caacgucuac ucccagacca acggcgccca gauccagggc     1500

ugcuccguca cccuccccca guccgucucc aagcaggccg ucggccacga ggagaacgcc     1560

cagugcugca aggccaccuc cgacaacguc auccaguccu ccgagaccug cuccucccag     1620

gacuccgcca ccaccaccuc cgcccucccc cccuccugga ccuccuccac cuccgucucc     1680

cagaagcaga agcgcaagac cggcaccaag cccuccaccg agccccagaa cgaggccguc     1740

accaacgucg agucccagaa caccaaccgc aacaacucca ccgcccucca gcucgccucc     1800

cgcccccccg acuccgucac cgagggcccc accuccaagc gcgcccacau caagcccaac     1860

gcccuccuca ccaacgucga ccagaucguc caggagaccc agcgccucga gcucaucuga     1920


<210>  1641
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG61560

<400>  1641
auggagaaga uccuguucua ccucuuucuu auuggcauag ccgugaaagc ucagaucugc       60

cccaagagau gugucugcca aauucugagc ccuaacuugg caaccuuaug ugccaaaaag      120

gggcugcuau ucguuccacc gaauaucgac aggcggacag uggaacuccg ccuggcggau      180

aacuuuguaa cuaauauuaa acgaaaggac uucgcuaaca ugacgucccu uguggaucug      240

accuugucuc guaauacaau cucauuuaua acuccccacg ccuucgcaga ccucagaaac      300

cugaggaguc ugcaucucaa uagcaaccgg uuaaccaaga ucacaaauga uauguuuucc      360

ggacugucua accuucacca uuugauucug aauaacaauc agcuaacccu caucucguca      420

acugccuucg acgaugucuu ugcucuggag gaacuugacc ugagcuauaa caauuuggag      480

acaauuccuu gggaugcagu ggaaaagaug guuagucucc acacccuguc cuuagaccau      540

aacaugaucg auaacauacc aaaggguacg uucucucacc uucacaaaau gacucgccuc      600

gacgugacca gcaauaagcu gcagaaacug cccccugauc cauuguuuca gagagcccaa      660

guccuagcua cauccggcau uaucucaccc aguacuuucg cccugagcuu ugggggaaac      720

ccucuccauu gcaauuguga gcugcuuugg cugaggcggu ugucucgcga guacgaccuc      780

gaaaccugcg cguccccacc gcuguuaaca ggccgauauu ucuggucaau ucccgaggaa      840

gaguuccugu gugagccucc acuaaucacc agacacacgc augaaaugag ggugcucgag      900

ggucagcggg caacucugcg uugcaaggcc cgcggggacc ccgaaccugc uauccacugg      960

auuagcccag agggaaaacu uauaaguaac gccacaagau cuuugguaua cgauaauggc     1020

acccuggaca uccucauuac uacaguuaaa gauaccggcg cauuuacgug uaucgcuucc     1080

aaccccgccg gggaagcgac ccagauagug gaccugcaca uuaucaaacu uccgcaucug     1140

uugaauagca caaaccacau ccaugagccu gaucccggau cgucugacau uuccacuuca     1200

accaagagug guagcaauac auccucuagc aacgauggca ucacuucacu caccgccaca     1260

agggucgugg ggugcauuca guucaccacu gagcaagacu augugcggug ucacuuuaug     1320

cagagucagu uccugggagg cacgaugaua aucauuaucg gugggaucau ugucgcaucc     1380

guuuuagugu uuauaaucau ucugaugauc cgauacaagg uaugcaauaa caauggacag     1440

cauaaaguga caaaggucag caacguguau ucucaaacca auggcgcuca gauucagggc     1500

ugcucaguua cucuaccaca aagugugagc aaacaggccg ucgggcacga agagaacgcu     1560

caguguugca aggccaccuc cgauaacgug auccagucuu cggaaacaug uagcucccaa     1620

gacucagcaa ccacuacaag ugcccucccu cccucuugga cgagcuccac cucaguaagc     1680

cagaagcaga aacgcaagac uggaacaaaa ccaucuaccg agccccagaa ugaagcuguu     1740

acaaacgugg agucccaaaa uacuaacaga aauaacagua ccgcgcugca gcuugcaagc     1800

aggccuccag auucugucac ggaggguccg accuccaagc gggcccacau aaaacccaau     1860

gcuuugcuga caaacgugga ccagaucguc caggaaacuc aacgccucga gcugauuuga     1920


<210>  1642
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG61560

<400>  1642
auggagaaga uccuguucua ccuguuccug aucggcaucg ccgugaaggc ccagaucugc       60

cccaagagau gcgugugcca gauccugagc cccaaccugg ccacccugug cgccaagaag      120

ggccugcugu ucgugccccc caacaucgac agaagaaccg uggagcugag acuggccgac      180

aacuucguga ccaacaucaa gagaaaggac uucgccaaca ugaccagccu gguggaccug      240

acccugagca gaaacaccau cagcuucauc accccccacg ccuucgccga ccugagaaac      300

cugagaagcc ugcaccugaa cagcaacaga cugaccaaga ucaccaacga cauguucagc      360

ggccugagca accugcacca ccugauccug aacaacaacc agcugacccu gaucagcagc      420

accgccuucg acgacguguu cgcccuggag gagcuggacc ugagcuacaa caaccuggag      480

accauccccu gggacgccgu ggagaagaug gugagccugc acacccugag ccuggaccac      540

aacaugaucg acaacauccc caagggcacc uucagccacc ugcacaagau gaccagacug      600

gacgugacca gcaacaagcu gcagaagcug ccccccgacc cccuguucca gagagcccag      660

gugcuggcca ccagcggcau caucagcccc agcaccuucg cccugagcuu cggcggcaac      720

ccccugcacu gcaacugcga gcugcugugg cugagaagac ugagcagaga guacgaccug      780

gagaccugcg ccagcccccc ccugcugacc ggcagauacu ucuggagcau ccccgaggag      840

gaguuccugu gcgagccccc ccugaucacc agacacaccc acgagaugag agugcuggag      900

ggccagagag ccacccugag augcaaggcc agaggcgacc ccgagcccgc cauccacugg      960

aucagccccg agggcaagcu gaucagcaac gccaccagaa gccuggugua cgacaacggc     1020

acccuggaca uccugaucac caccgugaag gacaccggcg ccuucaccug caucgccagc     1080

aaccccgccg gcgaggccac ccagaucgug gaccugcaca ucaucaagcu gccccaccug     1140

cugaacagca ccaaccacau ccacgagccc gaccccggca gcagcgacau cagcaccagc     1200

accaagagcg gcagcaacac cagcagcagc aacgacggca ucaccagccu gaccgccacc     1260

agaguggugg gcugcaucca guucaccacc gagcaggacu acgugagaug ccacuucaug     1320

cagagccagu uccugggcgg caccaugauc aucaucaucg gcggcaucau cguggccagc     1380

gugcuggugu ucaucaucau ccugaugauc agauacaagg ugugcaacaa caacggccag     1440

cacaagguga ccaaggugag caacguguac agccagacca acggcgccca gauccagggc     1500

ugcagcguga cccugcccca gagcgugagc aagcaggccg ugggccacga ggagaacgcc     1560

cagugcugca aggccaccag cgacaacgug auccagagca gcgagaccug cagcagccag     1620

gacagcgcca ccaccaccag cgcccugccc cccagcugga ccagcagcac cagcgugagc     1680

cagaagcaga agagaaagac cggcaccaag cccagcaccg agccccagaa cgaggccgug     1740

accaacgugg agagccagaa caccaacaga aacaacagca ccgcccugca gcuggccagc     1800

agaccccccg acagcgugac cgagggcccc accagcaaga gagcccacau caagcccaac     1860

gcccugcuga ccaacgugga ccagaucgug caggagaccc agagacugga gcugaucuga     1920


<210>  1643
<211>  1920
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG61560

<400>  1643
auggagaaga uccuguucua ccucuuucug auuggcaucg ccgugaaagc ucagauuugc       60

cccaagagau gugucugcca aauccuuagc ccuaaccugg ccacccucug ugcgaaaaag      120

gggcugcuuu ucguuccgcc caauauugac cggcgcacag uggaacugag acucgcugau      180

aacuuuguga cgaauaucaa acggaaggac uucgccaaca ugaccucccu ggucgaucug      240

acacucucuc gcaauaccau cagcuuuauu acaccucacg ccuucgcuga ccugagaaac      300

cuucgguccc ugcaucucaa uucuaaccgc cugaccaaga ucacaaauga uauguuuagc      360

ggacuuucca accugcacca ucucauucug aauaacaauc agcugacccu caucucuagc      420

acggccuucg acgauguguu ugcucuggag gaacuugacc uguccuauaa caaucucgag      480

accauucccu gggaugccgu ugagaaaaug gugagccugc acacacuuuc ucuggaccau      540

aacaugaucg auaacauucc uaagggcacc uucucccacc uccacaaaau gacaagacug      600

gacgucacca gcaauaagcu gcagaaacug cccccugauc cgcuguuuca gcgggcgcaa      660

gugcuugcca cgucugggau caucuccccc agcacauucg cucugucuuu uggaggcaac      720

ccucuccauu gcaauuguga acugcuuugg cugcgcagac ucucccggga guacgaccug      780

gaaaccugcg ccagcccucc ccugcucaca gggcgcuauu ucugguccau ucccgaggaa      840

gaguuccugu gugagccgcc ucuuaucacc agacacaccc augaaaugcg gguucuggag      900

ggacagcgcg cuacacucag augcaaggcc cggggcgacc ccgaaccugc gauucacugg      960

aucucucccg agggcaagcu gauuagcaac gccacgagau cccuggugua cgauaauggg     1020

acccuugaca uccucaucac aaccgucaaa gauacaggag cuuuuaccug uauugccagc     1080

aaccccgcug gcgaagccac gcagaucgug gaccugcaca uuaucaagcu gccucaucuc     1140

cucaauucua caaaccacau ucaugagccg gaucccgggu ccagcgacau cucuaccagc     1200

accaaauccg gaucuaauac aagcuccagc aacgauggca ucaccucucu uacagccacg     1260

cgcguggucg ggugcauuca guucaccaca gagcaagacu auguucggug ucacuuuaug     1320

cagucccagu uccugggagg caccaugauc auuaucauug gcgggaucau uguggcuagc     1380

gugcucgucu uuaucaucau ucugaugauc agauacaagg ugugcaauaa caauggacag     1440

cauaaaguua caaagguguc uaacgucuau ucccaaacca auggcgcgca gauucagggg     1500

ugcagcguga cgcugccuca auccguuucu aaacaggccg ugggacacga agagaacgcu     1560

caguguugca aggccaccag cgauaacguc auccaguccu cugaaacaug uagcucccaa     1620

gacagcgcca ccacaaccuc ugcccuuccc ccuuccugga cgagcucuac auccgugagc     1680

cagaagcaga aacgcaagac cggcacaaaa cccucuaccg agccgcagaa ugaagcuguc     1740

accaacgugg agagccaaaa uacaaaccgg aauaacucca cggcgcucca gcuggcuagc     1800

agaccucccg auucuguuac cgaggggccu acauccaagc gcgcccacau uaaacccaau     1860

gcccugcuca ccaacgugga ccagaucguc caggaaacac aacggcugga gcuuaucuga     1920


<210>  1644
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DTH2

<400>  1644

Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr 
1               5                   10                  15      


Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly 
            20                  25                  30          


Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr His 
        35                  40                  45              


Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln 
    50                  55                  60                  


Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr 
65                  70                  75                  80  


Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro 
                85                  90                  95      


Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly 
            100                 105                 110         


Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp 
        115                 120                 125             


Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn Ser 
    130                 135                 140                 


Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro 
145                 150                 155                 160 


Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser 
                165                 170                 175     


Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly 
            180                 185                 190         


His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn 
        195                 200                 205             


Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met 
    210                 215                 220                 


Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp 
225                 230                 235                 240 


Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly 
                245                 250                 255     


Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys 
            260                 265                 270         


Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly 
        275                 280                 285             


Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr 
    290                 295                 300                 


Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile 
305                 310                 315                 320 


Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser Arg 
                325                 330                 335     


Glu 
    


<210>  1645
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG61984

<400>  1645
augaucuuug aggaacaugg uuuuaggcgg accacaccgc ccacaacggc cacccccaua       60

aggcauaggc caagaccaua cccgccgaau guaggugagg aaauccaaau uggucacauc      120

cccagggaag auguagacua ucaccuguac ccacacgguc cgggacucaa uccaaaugcc      180

ucuacaggac aagaagcucu cucucagaca accaucucau gggccccauu ccaggacacu      240

ucugaguaca ucauuucaug ucauccuguu ggcacugaug aagaacccuu acaguucagg      300

guuccuggaa cuucuaccag ugccacucug acaggccuca ccagaggugc caccuacaac      360

aucauagugg aggcacugaa agaccagcag aggcauaagg uucgggaaga gguuguuacc      420

gugggcaacu cugucaacga aggcuugaac caaccuacgg augacucgug cuuugacccc      480

uacacaguuu cccauuaugc cguuggagau gagugggaac gaaugucuga aucaggcuuu      540

aaacuguugu gccagugcuu aggcuuugga aguggucauu ucagauguga uucaucuaga      600

uggugccaug acaauggugu gaacuacaag auuggagaga agugggaccg ucagggagaa      660

aauggccaga ugaugagcug cacaugucuu gggaacggaa aaggagaauu caagugugac      720

ccucaugagg caacguguua ugaugauggg aagacauacc acguaggaga acaguggcag      780

aaggaauauc ucggugccau uugcuccugc acaugcuuug gaggccagcg gggcuggcgc      840

ugugacaacu gccgcagacc ugggggugaa cccagucccg aaggcacuac uggccagucc      900

uacaaccagu auucucagag auaccaucag agaacaaaca cuaauguuaa uugcccaauu      960

gagugcuuca ugccuuuaga uguacaggcu gacagagaag auucccgaga guaa           1014


<210>  1646
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG61984

<400>  1646
augaucuucg aggagcacgg cuuccgccgg accacgcccc cgaccaccgc cacccccauc       60

cgccaccggc cccgccccua cccgcccaac gugggggagg agauccagau cggccacauc      120

ccccgggagg acgucgacua ccaccuguac ccccacgggc cgggccucaa ccccaacgcc      180

agcaccgggc aggaggcccu gucccagacg accaucagcu gggcccccuu ccaggacacc      240

uccgaguaca ucaucagcug ccaccccgug ggcaccgacg aggagccgcu gcaguuccgc      300

gugcccggca cguccaccag cgccacccuc accgggcuga cgcggggcgc caccuacaac      360

aucaucgucg aggcccugaa ggaccagcag cgccacaagg ugcgggagga gguggucacc      420

guggggaacu ccgugaacga gggccucaac cagcccaccg acgacagcug cuucgacccc      480

uacacggucu cccacuacgc ggugggggac gagugggagc gcaugagcga guccggcuuc      540

aagcugcugu gccagugccu cggcuucggg agcggccacu uccggugcga cuccagccgc      600

uggugccacg acaacggggu gaacuacaag aucggcgaga agugggaccg gcagggcgag      660

aacgggcaga ugauguccug cacgugccug ggcaacggga agggcgaguu caagugcgac      720

ccgcacgagg cgaccugcua cgacgacggg aagaccuacc acgucggcga gcaguggcag      780

aaggaguacc ugggcgccau cugcagcugc acgugcuucg ggggccagcg cggguggcgg      840

ugcgacaacu gccgccggcc cggcggggag cccucccccg agggcaccac cggccagagc      900

uacaaccagu acucccagcg cuaccaccag cggaccaaca ccaacgugaa cugcccgauc      960

gagugcuuca ugccccucga cgugcaggcc gaccgcgagg acagccggga guga           1014


<210>  1647
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG61984

<400>  1647
augaucuucg aggagcacgg cuuccgccgc accacccccc ccaccaccgc cacccccauc       60

cgccaccgcc cccgccccua cccccccaac gucggcgagg agauccagau cggccacauc      120

ccccgcgagg acgucgacua ccaccucuac ccccacggcc ccggccucaa ccccaacgcc      180

uccaccggcc aggaggcccu cucccagacc accaucuccu gggcccccuu ccaggacacc      240

uccgaguaca ucaucuccug ccaccccguc ggcaccgacg aggagccccu ccaguuccgc      300

guccccggca ccuccaccuc cgccacccuc accggccuca cccgcggcgc caccuacaac      360

aucaucgucg aggcccucaa ggaccagcag cgccacaagg uccgcgagga ggucgucacc      420

gucggcaacu ccgucaacga gggccucaac cagcccaccg acgacuccug cuucgacccc      480

uacaccgucu cccacuacgc cgucggcgac gagugggagc gcauguccga guccggcuuc      540

aagcuccucu gccagugccu cggcuucggc uccggccacu uccgcugcga cuccucccgc      600

uggugccacg acaacggcgu caacuacaag aucggcgaga agugggaccg ccagggcgag      660

aacggccaga ugauguccug caccugccuc ggcaacggca agggcgaguu caagugcgac      720

ccccacgagg ccaccugcua cgacgacggc aagaccuacc acgucggcga gcaguggcag      780

aaggaguacc ucggcgccau cugcuccugc accugcuucg gcggccagcg cggcuggcgc      840

ugcgacaacu gccgccgccc cggcggcgag cccucccccg agggcaccac cggccagucc      900

uacaaccagu acucccagcg cuaccaccag cgcaccaaca ccaacgucaa cugccccauc      960

gagugcuuca ugccccucga cguccaggcc gaccgcgagg acucccgcga guga           1014


<210>  1648
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG61984

<400>  1648
augaucuucg aggaacacgg cuuuagaagg accacacccc cuacuacggc caccccaauu       60

cggcaucgcc cgcgacccua cccuccaaac gugggggagg aaauacagau cggacacauu      120

ccccgugagg acgucgauua ucaucuguac ccucacgguc caggccucaa ucccaacgcu      180

agcacagggc aagaagcacu uucccagacu accaucucuu gggccccuuu ccaggacaca      240

ucagaguaua uuaucaguug ccauccaguu ggaaccgaug aggaaccgcu gcaguuuaga      300

gugcccggca cuagcacauc cgcgaccuug acggguuuaa cuaggggagc uaccuacaau      360

auaaucguag aggcccugaa ggaccaacag cggcacaaag ugcgcgaaga ggucgugaca      420

guugggaacu cugugaauga gggccuaaac cagccuacug augacucgug uuucgaucca      480

uauaccgucu cacacuacgc agugggcgac gaaugggaga gaaugagcga aaguggguuu      540

aagcuccugu gccagugucu uggauucggu uccggccauu uuaggugcga uucuagccgg      600

uggugucacg acaauggggu aaacuauaaa auuggagaga agugggaucg ccaaggcgaa      660

aauggucaga ugauguccug cacaugucug gggaacggaa aaggcgaguu caagugcgac      720

ccccaugagg ccaccuguua cgaugacggc aagacguacc acguugggga acaguggcag      780

aaagaguauu ugggagcuau cugcucaugu acuugcuuug guggccaacg aggguggaga      840

ugcgacaauu guaggcggcc uggaggcgaa ccaagucccg aggguacaac cgggcagagc      900

uacaaccagu auucucaacg uuaccaccag cgcacuaaua caaacgugaa uugcccgauu      960

gaauguuuca ugccucucga uguccaggca gacagagagg auuccaggga guga           1014


<210>  1649
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG61984

<400>  1649
augaucuucg aggagcacgg cuucagaaga accacccccc ccaccaccgc cacccccauc       60

agacacagac ccagacccua cccccccaac gugggcgagg agauccagau cggccacauc      120

cccagagagg acguggacua ccaccuguac ccccacggcc ccggccugaa ccccaacgcc      180

agcaccggcc aggaggcccu gagccagacc accaucagcu gggcccccuu ccaggacacc      240

agcgaguaca ucaucagcug ccaccccgug ggcaccgacg aggagccccu gcaguucaga      300

gugcccggca ccagcaccag cgccacccug accggccuga ccagaggcgc caccuacaac      360

aucaucgugg aggcccugaa ggaccagcag agacacaagg ugagagagga gguggugacc      420

gugggcaaca gcgugaacga gggccugaac cagcccaccg acgacagcug cuucgacccc      480

uacaccguga gccacuacgc cgugggcgac gagugggaga gaaugagcga gagcggcuuc      540

aagcugcugu gccagugccu gggcuucggc agcggccacu ucagaugcga cagcagcaga      600

uggugccacg acaacggcgu gaacuacaag aucggcgaga agugggacag acagggcgag      660

aacggccaga ugaugagcug caccugccug ggcaacggca agggcgaguu caagugcgac      720

ccccacgagg ccaccugcua cgacgacggc aagaccuacc acgugggcga gcaguggcag      780

aaggaguacc ugggcgccau cugcagcugc accugcuucg gcggccagag aggcuggaga      840

ugcgacaacu gcagaagacc cggcggcgag cccagccccg agggcaccac cggccagagc      900

uacaaccagu acagccagag auaccaccag agaaccaaca ccaacgugaa cugccccauc      960

gagugcuuca ugccccugga cgugcaggcc gacagagagg acagcagaga guga           1014


<210>  1650
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG61984

<400>  1650
augaucuucg aggaacacgg cuuuagacgg accacacccc cuacgaccgc cacaccgauu       60

cgccauagac cccggccuua ucccccuaac gugggggagg aaauccagau uggacacauc      120

ccccgcgagg acgucgauua ccaucuguac ccucacggcc cggggcucaa ucccaacgcu      180

agcaccggac aagaagcccu gucccagaca accauuucuu gggcgccuuu ccaggacaca      240

agcgaguaua ucaucuccug ccaucccguu ggcaccgaug aggaaccucu ucaguuuaga      300

gugcccggga cgucuaccag cgcuacacug accggacuca cacggggcgc caccuacaau      360

auuaucgugg aggcccugaa ggaccaacag cgccacaaag ucagagaaga ggugguuacg      420

gugggcaacu ccgucaauga ggggcuuaac cagccgacag augacucuug uuucgauccu      480

uauaccguga gccacuacgc uguuggagac gaaugggagc ggauguccga aagcggcuuu      540

aagcugcucu gccagugucu gggguucgga ucuggccauu uucgcugcga uuccagcaga      600

uggugucacg acaauggggu gaacuauaaa auuggagaga agugggaucg gcaaggcgaa      660

aauggccaga ugaugucuug cacaugucug gggaacggaa aaggcgaguu caagugcgac      720

ccccaugagg ccaccuguua cgaugacggg aagaccuacc acgucggaga acaguggcag      780

aaagaguauc ucggcgcuau cugcuccugu acaugcuuug ggggacaacg cggcuggaga      840

ugcgacaauu gucggcgccc uggcggggaa cccagccccg agggaacgac cggccagucu      900

uacaaccagu auucccaaag auaccaccag cggacaaaua ccaacgugaa uugcccuauu      960

gaauguuuca ugccgcugga ugugcaggcc gacagagagg auagccgcga guga           1014


<210>  1651
<211>  1014
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DTK1

<400>  1651

Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr Asn Phe 
1               5                   10                  15      


Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala Glu Leu 
            20                  25                  30          


Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu Leu Pro 
        35                  40                  45              


Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln His Glu 
    50                  55                  60                  


Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser Pro Thr 
65                  70                  75                  80  


Gly Ile Asp Phe Ser Asp Ile Thr Gly Asn Ser Phe Thr Val His Trp 
                85                  90                  95      


Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His His Pro 
            100                 105                 110         


Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His Ser Arg 
        115                 120                 125             


Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr Val Val 
    130                 135                 140                 


Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu Ile Gly 
145                 150                 155                 160 


Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala 
                165                 170                 175     


Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
            180                 185                 190         


Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro 
        195                 200                 205             


Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
    210                 215                 220                 


Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr 
225                 230                 235                 240 


Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr 
                245                 250                 255     


Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp Val Gln 
            260                 265                 270         


Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro Val Thr 
        275                 280                 285             


Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro Thr Lys 
    290                 295                 300                 


Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu Gly Leu 
305                 310                 315                 320 


Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn Pro Ser 
                325                 330                 335     


Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Thr Ile Pro Ala 
            340                 345                 350         


Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala 
        355                 360                 365             


Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val 
    370                 375                 380                 


Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro 
385                 390                 395                 400 


Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr 
                405                 410                 415     


Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala 
            420                 425                 430         


Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala 
        435                 440                 445             


Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr 
    450                 455                 460                 


Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn 
465                 470                 475                 480 


Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr 
                485                 490                 495     


Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr 
            500                 505                 510         


Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser 
        515                 520                 525             


Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro 
    530                 535                 540                 


Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly 
545                 550                 555                 560 


Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val 
                565                 570                 575     


Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu 
            580                 585                 590         


Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln 
        595                 600                 605             


Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln 
    610                 615                 620                 


Leu Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp 
625                 630                 635                 640 


Val Pro Ser Thr Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr 
                645                 650                 655     


Asp Thr Gly Asn Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro 
            660                 665                 670         


Ser Val Gly Gln Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr 
        675                 680                 685             


Thr Pro Pro Thr Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr 
    690                 695                 700                 


Pro Pro Asn Val Gly Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu 
705                 710                 715                 720 


Asp Val Asp Tyr His Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn 
                725                 730                 735     


Ala Ser Thr Gly Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala 
            740                 745                 750         


Pro Phe Gln Asp Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly 
        755                 760                 765             


Thr Asp Glu Glu Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser 
    770                 775                 780                 


Ala Thr Leu Thr Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val 
785                 790                 795                 800 


Glu Ala Leu Lys Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val 
                805                 810                 815     


Thr Val Gly Asn Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp 
            820                 825                 830         


Ser Cys Phe Asp Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu 
        835                 840                 845             


Trp Glu Arg Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu 
    850                 855                 860                 


Gly Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His 
865                 870                 875                 880 


Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly 
                885                 890                 895     


Glu Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly 
            900                 905                 910         


Glu Phe Lys Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys 
        915                 920                 925             


Thr Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile 
    930                 935                 940                 


Cys Ser Cys Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn 
945                 950                 955                 960 


Cys Arg Arg Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln 
                965                 970                 975     


Ser Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn 
            980                 985                 990         


Val Asn Cys Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp 
        995                 1000                1005            


Arg Glu Asp Ser Arg Glu 
    1010                


<210>  1652
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG62013

<400>  1652
augcguguca ccugggcucc acccccaucc auugauuuaa ccaacuuccu ggugcguuac       60

ucaccuguga aaaaugagga agauguugca gaguugucaa uuucuccuuc agacaaugca      120

guggucuuaa caaaucuccu gccugguaca gaauauguag ugagugucuc cagugucuac      180

gaacaacaug agagcacacc ucuuagagga agacagaaaa caggucuuga uuccccaacu      240

ggcauugacu uuucugauau uacuggcaac ucuuuuacug ugcacuggau ugcuccucga      300

gccaccauca cuggcuacag gauccgccau caucccgagc acuucagugg gagaccucga      360

gaagaucggg ugccccacuc ucggaauucc aucacccuca ccaaccucac uccaggcaca      420

gaguaugugg ucagcaucgu ugcucuuaau ggcagagagg aaagucccuu auugauuggc      480

caacaaucaa caguuucuga uguuccgagg gaccuggaag uuguugcugc gacccccacc      540

agccuacuga ucagcuggga ugcuccugcu gucacaguga gauauuacag gaucacuuac      600

ggagaaacag gaggaaauag cccuguccag gaguucacug ugccugggag caagucuaca      660

gcuaccauca gcggccuuaa accuggaguu gauuauacca ucacugugua ugcugucacu      720

ggccguggag acagccccgc aagcagcaag ccaauuucca uuaauuaccg aacagaaauu      780

gacaaaccau cccagaugca agugaccgau guucaggaca acagcauuag ugucaagugg      840

cugccuucaa guuccccugu uacugguuac agaguaacca ccacucccaa aaauggacca      900

ggaccaacaa aaacuaaaac ugcaggucca gaucaaacag aaaugacuau ugaaggcuug      960

cagcccacag uggaguaugu gguuaguguc uaugcucaga auccaagcgg agagagucag     1020

ccucugguuc agacugcagu aaccacuauu ccugcaccaa cugaccugaa guucacucag     1080

gucacaccca caagccugag cgcccagugg acaccaccca auguucagcu cacuggauau     1140

cgagugcggg ugacccccaa ggagaagacc ggaccaauga aagaaaucaa ccuugcuccu     1200

gacagcucau ccgugguugu aucaggacuu augguggcca ccaaauauga agugaguguc     1260

uaugcucuua aggacacuuu gacaagcaga ccagcucagg guguugucac cacucuggag     1320

aaugucagcc caccaagaag ggcucgugug acagaugcua cugagaccac caucaccauu     1380

agcuggagaa ccaagacuga gacgaucacu ggcuuccaag uugaugccgu uccagccaau     1440

ggccagacuc caauccagag aaccaucaag ccagauguca gaagcuacac caucacaggu     1500

uuacaaccag gcacugacua caagaucuac cuguacaccu ugaaugacaa ugcucggagc     1560

uccccugugg ucaucgacgc cuccacugcc auugaugcac cauccaaccu gcguuuccug     1620

gccaccacac ccaauuccuu gcugguauca uggcagccgc cacgugccag gauuaccggc     1680

uacaucauca aguaugagaa gccugggucu ccucccagag aagugguccc ucggccccgc     1740

ccugguguca cagaggcuac uauuacuggc cuggaaccgg gaaccgaaua uacaauuuau     1800

gucauugccc ugaagaauaa ucagaagagc gagccccuga uuggaaggaa aaagacagac     1860

gagcuucccc aacugguaac ccuuccacac cccaaucuuc auggaccaga gaucuuggau     1920

guuccuucca caguucaaaa gaccccuuuc gucacccacc cuggguauga cacuggaaau     1980

gguauucagc uuccuggcac uucuggucag caacccagug uugggcaaca aaugaucuuu     2040

gaggaacaug guuuuaggcg gaccacaccg cccacaacgg ccacccccau aaggcauagg     2100

ccaaggccau acccgccgaa uguaggugag gaaauccaaa uuggucacau ccccagggaa     2160

gauguagacu aucaccugua cccacacggu ccgggacuca auccaaaugc cucuacagga     2220

caagaagcuc ucucucagac aaccaucuca ugggccccau uccaggacac uucugaguac     2280

aucauuucau gucauccugu uggcacugau gaagaacccu uacaguucag gguuccugga     2340

acuucuacca gugccacucu gacaggccuc accagaggug ccaccuacaa caucauagug     2400

gaggcacuga aagaccagca gaggcauaag guucgggaag agguuguuac cgugggcaac     2460

ucugucaacg aaggcuugaa ccaaccuacg gaugacucgu gcuuugaccc cuacacaguu     2520

ucccauuaug ccguuggaga ugagugggaa cgaaugucug aaucaggcuu uaaacuguug     2580

ugccagugcu uaggcuuugg aaguggccau uucagaugug auucaucuag auggugccau     2640

gacaauggug ugaacuacaa gauuggagag aagugggacc gucagggaga aaauggccag     2700

augaugagcu gcacaugucu ugggaacgga aaaggagaau ucaaguguga cccucaugag     2760

gcaacguguu acgaugaugg gaagacauac cacguaggag aacaguggca gaaggaauau     2820

cucggugcca uuugcuccug cacaugcuuu ggaggccagc ggggcuggcg cugugacaac     2880

ugccgcagac cuggggguga acccaguccc gaaggcacua cuggccaguc cuacaaccag     2940

uauucucaga gauaccauca gagaacaaac acuaauguua auugcccaau ugagugcuuc     3000

augccuuuag auguacaggc ugacagagaa gauucccgag aguaa                     3045


<210>  1653
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG62013

<400>  1653
augcgcguga ccugggcccc cccgcccagc aucgaccuga ccaacuuccu cguccgguac       60

ucccccguga agaacgagga ggacguggcc gagcugagca ucucccccag cgacaacgcg      120

gucgugcuga cgaaccuccu gccgggcacc gaguacgugg ucuccgugag cuccguguac      180

gagcagcacg agagcacccc ccugcgcggg cggcagaaga ccggccucga cucccccacg      240

gggaucgacu ucagcgacau caccggcaac uccuucaccg uccacuggau cgccccccgc      300

gccaccauca cgggguaccg gauccgccac cacccggagc acuucagcgg ccggccccgc      360

gaggaccggg ugccccacuc ccgcaacagc aucacccuga ccaaccugac ccccggcacg      420

gaguacgugg ucuccaucgu ggcccucaac gggcgggagg agagcccgcu gcugaucggc      480

cagcagucca ccgugagcga cgucccccgc gaccucgagg ugguggccgc gacccccacc      540

ucccugcuga ucagcuggga cgcccccgcc gucacggugc gguacuaccg caucaccuac      600

ggggagaccg gcgggaacag cccggugcag gaguucaccg uccccggcuc caagagcacg      660

gccaccaucu ccggccucaa gcccggggug gacuacacca ucaccgugua cgcggucacg      720

ggccgggggg acagccccgc cuccagcaag ccgaucucca ucaacuaccg caccgagauc      780

gacaagccca gccagaugca ggugaccgac guccaggaca acuccaucag cgugaagugg      840

cugcccucca gcucccccgu gaccggcuac cgggucacga ccaccccgaa gaacggcccc      900

gggcccacca agacgaagac cgccggcccc gaccagaccg agaugaccau cgaggggcug      960

cagccgacgg uggaguacgu ggucagcgug uacgcccaga accccuccgg cgagagccag     1020

ccccucgugc agaccgccgu caccaccauc ccggcgccca ccgaccugaa guucacgcag     1080

gugaccccca ccucccugag cgcccagugg acccccccga acgugcagcu cacgggguac     1140

cgcguccggg ugacccccaa ggagaagacc ggccccauga aggagaucaa ccuggccccc     1200

gacuccagca gcguggucgu guccggccug augguggcca ccaaguacga ggucagcgug     1260

uacgcccuca aggacacgcu gaccucccgc ccggcgcagg ggguggucac cacccuggag     1320

aacgugagcc ccccccggcg cgcccgcgug acggacgcca ccgagaccac caucacgauc     1380

uccuggcgga ccaagaccga gaccaucacg ggcuuccagg ucgacgccgu gcccgccaac     1440

gggcagaccc cgauccagcg caccaucaag cccgacgugc ggagcuacac caucacgggc     1500

cuccagcccg ggaccgacua caagaucuac cuguacaccc ugaacgacaa cgcgcgcucc     1560

agccccgucg ugaucgacgc cuccaccgcc aucgacgccc cgagcaaccu ccgguuccug     1620

gccacgaccc ccaacucccu gcucgugagc uggcagcccc cccgcgcgcg gaucaccggc     1680

uacaucauca aguacgagaa gccgggcucc cccccccgcg aggucgugcc ccggccgcgc     1740

cccgggguga ccgaggccac gaucaccggc cuggagcccg ggaccgagua caccaucuac     1800

gucaucgccc ugaagaacaa ccagaagagc gagccgcuca ucggccggaa gaagacggac     1860

gagcugcccc agcuggugac ccucccccac cccaaccugc acgggccgga gauccuggac     1920

gugcccucca ccguccagaa gacccccuuc gugacccacc ccggcuacga cacgggcaac     1980

gggauccagc ucccgggcac cagcgggcag cagcccuccg ugggccagca gaugaucuuc     2040

gaggagcacg gcuuccgccg gaccaccccc cccacgaccg ccaccccgau ccgccaccgg     2100

ccccgccccu accccccgaa cgucggggag gagauccaga ucggccacau cccccgggag     2160

gacguggacu accaccugua cccccacggg cccggccuga acccgaacgc gagcaccggg     2220

caggaggccc ucagccagac gaccaucucc ugggcccccu uccaggacac cagcgaguac     2280

aucaucuccu gccaccccgu gggcaccgac gaggagcccc ugcaguuccg cgucccgggc     2340

acgagcaccu ccgccacccu gaccgggcuc acgcggggcg ccaccuacaa caucaucgug     2400

gaggcgcuga aggaccagca gcgccacaag gugcgcgagg aggucgugac cguggggaac     2460

agcgucaacg agggccugaa ccagcccacc gacgacuccu gcuucgaccc cuacacggug     2520

agccacuacg ccguggggga cgagugggag cggauguccg agagcggcuu caagcugcuc     2580

ugccagugcc ugggcuucgg guccggccac uuccgcugcg acagcucccg guggugccac     2640

gacaacgggg ucaacuacaa gaucggcgag aagugggacc gccaggggga gaacggccag     2700

augaugagcu gcaccugccu gggcaacggg aagggcgagu ucaagugcga cccccacgag     2760

gccaccugcu acgacgacgg gaagaccuac cacgugggcg agcaguggca gaaggaguac     2820

cucggggcca ucugcuccug cacgugcuuc ggcggccagc ggggguggcg cugcgacaac     2880

ugccggcgcc cgggcgggga gcccagcccc gagggcacca ccggccaguc cuacaaccag     2940

uacagccagc gguaccacca gcgcaccaac acgaacguca acugcccgau cgagugcuuc     3000

augccccugg acgugcaggc cgaccgggag gacucccgcg aguga                     3045


<210>  1654
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG62013

<400>  1654
augcgcguca ccugggcccc cccccccucc aucgaccuca ccaacuuccu cguccgcuac       60

ucccccguca agaacgagga ggacgucgcc gagcucucca ucucccccuc cgacaacgcc      120

gucguccuca ccaaccuccu ccccggcacc gaguacgucg ucuccgucuc cuccgucuac      180

gagcagcacg aguccacccc ccuccgcggc cgccagaaga ccggccucga cucccccacc      240

ggcaucgacu ucuccgacau caccggcaac uccuucaccg uccacuggau cgccccccgc      300

gccaccauca ccggcuaccg cauccgccac caccccgagc acuucuccgg ccgcccccgc      360

gaggaccgcg ucccccacuc ccgcaacucc aucacccuca ccaaccucac ccccggcacc      420

gaguacgucg ucuccaucgu cgcccucaac ggccgcgagg aguccccccu ccucaucggc      480

cagcagucca ccgucuccga cgucccccgc gaccucgagg ucgucgccgc cacccccacc      540

ucccuccuca ucuccuggga cgcccccgcc gucaccgucc gcuacuaccg caucaccuac      600

ggcgagaccg gcggcaacuc ccccguccag gaguucaccg uccccggcuc caaguccacc      660

gccaccaucu ccggccucaa gcccggcguc gacuacacca ucaccgucua cgccgucacc      720

ggccgcggcg acucccccgc cuccuccaag cccaucucca ucaacuaccg caccgagauc      780

gacaagcccu cccagaugca ggucaccgac guccaggaca acuccaucuc cgucaagugg      840

cuccccuccu ccucccccgu caccggcuac cgcgucacca ccacccccaa gaacggcccc      900

ggccccacca agaccaagac cgccggcccc gaccagaccg agaugaccau cgagggccuc      960

cagcccaccg ucgaguacgu cgucuccguc uacgcccaga accccuccgg cgagucccag     1020

ccccucgucc agaccgccgu caccaccauc cccgccccca ccgaccucaa guucacccag     1080

gucaccccca ccucccucuc cgcccagugg acccccccca acguccagcu caccggcuac     1140

cgcguccgcg ucacccccaa ggagaagacc ggccccauga aggagaucaa ccucgccccc     1200

gacuccuccu ccgucgucgu cuccggccuc auggucgcca ccaaguacga ggucuccguc     1260

uacgcccuca aggacacccu caccucccgc cccgcccagg gcgucgucac cacccucgag     1320

aacgucuccc ccccccgccg cgcccgcguc accgacgcca ccgagaccac caucaccauc     1380

uccuggcgca ccaagaccga gaccaucacc ggcuuccagg ucgacgccgu ccccgccaac     1440

ggccagaccc ccauccagcg caccaucaag cccgacgucc gcuccuacac caucaccggc     1500

cuccagcccg gcaccgacua caagaucuac cucuacaccc ucaacgacaa cgcccgcucc     1560

ucccccgucg ucaucgacgc cuccaccgcc aucgacgccc ccuccaaccu ccgcuuccuc     1620

gccaccaccc ccaacucccu ccucgucucc uggcagcccc cccgcgcccg caucaccggc     1680

uacaucauca aguacgagaa gcccggcucc cccccccgcg aggucguccc ccgcccccgc     1740

cccggcguca ccgaggccac caucaccggc cucgagcccg gcaccgagua caccaucuac     1800

gucaucgccc ucaagaacaa ccagaagucc gagccccuca ucggccgcaa gaagaccgac     1860

gagcuccccc agcucgucac ccucccccac cccaaccucc acggccccga gauccucgac     1920

guccccucca ccguccagaa gacccccuuc gucacccacc ccggcuacga caccggcaac     1980

ggcauccagc uccccggcac cuccggccag cagcccuccg ucggccagca gaugaucuuc     2040

gaggagcacg gcuuccgccg caccaccccc cccaccaccg ccacccccau ccgccaccgc     2100

ccccgccccu acccccccaa cgucggcgag gagauccaga ucggccacau cccccgcgag     2160

gacgucgacu accaccucua cccccacggc cccggccuca accccaacgc cuccaccggc     2220

caggaggccc ucucccagac caccaucucc ugggcccccu uccaggacac cuccgaguac     2280

aucaucuccu gccaccccgu cggcaccgac gaggagcccc uccaguuccg cguccccggc     2340

accuccaccu ccgccacccu caccggccuc acccgcggcg ccaccuacaa caucaucguc     2400

gaggcccuca aggaccagca gcgccacaag guccgcgagg aggucgucac cgucggcaac     2460

uccgucaacg agggccucaa ccagcccacc gacgacuccu gcuucgaccc cuacaccguc     2520

ucccacuacg ccgucggcga cgagugggag cgcauguccg aguccggcuu caagcuccuc     2580

ugccagugcc ucggcuucgg cuccggccac uuccgcugcg acuccucccg cuggugccac     2640

gacaacggcg ucaacuacaa gaucggcgag aagugggacc gccagggcga gaacggccag     2700

augauguccu gcaccugccu cggcaacggc aagggcgagu ucaagugcga cccccacgag     2760

gccaccugcu acgacgacgg caagaccuac cacgucggcg agcaguggca gaaggaguac     2820

cucggcgcca ucugcuccug caccugcuuc ggcggccagc gcggcuggcg cugcgacaac     2880

ugccgccgcc ccggcggcga gcccuccccc gagggcacca ccggccaguc cuacaaccag     2940

uacucccagc gcuaccacca gcgcaccaac accaacguca acugccccau cgagugcuuc     3000

augccccucg acguccaggc cgaccgcgag gacucccgcg aguga                     3045


<210>  1655
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG62013

<400>  1655
augagaguga ccugggcccc gccuccaagc aucgaccuga caaacuuccu cgucagguac       60

uccccgguua agaaugagga agauguggcu gagcuuucua uuucacccag ugacaacgca      120

guagugcuga cuaauuuguu accuggcacg gaauaugucg ugagcguuuc cucuguguac      180

gagcagcacg aaucgacccc acugcggggg cgccagaaaa caggacuaga uucacccacu      240

gguauagacu uuagcgauau caccggcaac aguuucacag uccauuggau ugccccucga      300

gcgaccauca cuggguaucg uauuagacac cauccagagc acuuuuccgg aaggccccgg      360

gaggaccgcg ugccucauuc uagaaauagc aucacacuca ccaaccugac gccaggcacu      420

gaauacguag uuuccauagu ggcucuuaau gguagggagg aaucaccgcu guugaucggg      480

cagcagagua ccgucagcga ugugccccgg gaccucgagg uggucgccgc aacaccuacu      540

ucucugcuga uuuccuggga ugccccagcu guuaccgugc gcuauuaccg aaucacauau      600

ggagagaccg gcggcaacuc acccguacag gaguucacgg ugccugggag caagaguacu      660

gcaacaauuu cuggacucaa accagguguc gacuacacca ucacugugua cgccguuaca      720

ggcagagggg auucccccgc uagcucgaag ccgauaucua uuaauuauag gaccgaaauc      780

gacaaaccuu cccaaaugca agugacggau guccaggaca acucaauuag ugugaagugg      840

uuacccagcu ccucuccagu aaccggauac cggguuacaa cuaccccuaa gaauggcccc      900

gguccaacaa aaacuaagac cgccgggccc gaccagacag aaaugaccau cgagggacug      960

caaccuacug uggaauaugu cgugagcguc uacgcgcaga acccaucagg cgagagucag     1020

ccgcuugugc agacggcagu uacaaccauc cccgccccua cugauuugaa auuuacccaa     1080

gugacaccaa ccucccugag cgcucagugg acucccccua auguacagcu aacaggcuau     1140

cguguccgcg ugacgccaaa ggagaaaacc gggcccauga aggaaauuaa ccucgccccg     1200

gacucuucaa guguuguggu cagcggacug augguggcaa cuaaguacga gguauccgug     1260

uaugcucuua aagauacacu gaccucuaga ccugcccaag guguugucac aacuuuggaa     1320

aaugugucgc cacccaggcg ggcgcgagug accgacgcca cggagaccac aauaacuauc     1380

agcuggcgca ccaagacaga aacuauuacc ggcuuccagg ucgaugcagu uccugcuaac     1440

gggcagacgc ccauccagag aacaauaaaa ccagacguga gguccuacac cauuacugga     1500

cuccaaccug gcacagauua caagaucuau cuguacaccu uaaacgacaa ugcccgguca     1560

agucccgugg uaaucgaugc uucuacugcc auugacgcac caagcaaccu gcgcuuucuc     1620

gccaccacac ccaauucccu ucuggucuca uggcagccuc ccagagcuag gaucacgggu     1680

uauauuauaa aauacgagaa gccagggucu cccccucgug aggugguucc acggccccga     1740

ccuggcguga ccgaagcgac uaucacagga uuggagccgg gcaccgaaua uacaauuuac     1800

gucaucgcac uaaagaacaa ucagaaaagc gagccacuga ucgggagaaa gaaaacugau     1860

gaacuccccc agcuggugac ccuuccucac ccaaaccugc acggacccga gauuuuggac     1920

guuccuucca cggugcaaaa gacaccguuc guaacccauc ccgguuauga cacuggcaau     1980

gggauacagc ucccaggaac caguggccag cagccuagcg ucggucaaca gaugaucuuu     2040

gaggaacacg gguucaggcg cacaacuccc ccaaccacag ccacgccuau ucggcauaga     2100

cccaggccau acccgccuaa cgugggcgag gaaauccaga uuggacacau cccccgcgag     2160

gauguggacu accaccugua uccacauggc cccggguuaa auccuaacgc uucuaccgga     2220

caggaggccc ugucccaaac uacaauauca ugggcaccau uucaggauac cagugaauac     2280

aucauuagcu gccaccccgu cgguacugac gaggaaccuc uacaguuccg aguuccgggc     2340

acaucgaccu ccgccacgcu cacugggcug acccggggag cuacauauaa uaucauugug     2400

gaggcccuua aagaucaaca gcgucauaag guaagagaag agguggucac cgugggcaac     2460

ucuguuaaug aggguuugaa ccagccaacu gacgauagcu guuuugaccc cuacacagug     2520

ucacacuaug cagucgggga ugaaugggag aggaugagug aauccggcuu caaacugcuc     2580

ugccaguguc ugggauucgg cucugggcau uuucgcugcg acagcucccg guggugucac     2640

gauaauggag ugaacuacaa gaucggcgag aagugggaca gacaagguga aaacgggcag     2700

augaugucau gcaccugucu uggaaauggc aaaggugagu ucaagugcga uccucacgag     2760

gcgacauguu augacgacgg caaaacuuac cauguugggg aacaguggca gaaggaguac     2820

cugggagcua uaugcagcug uaccugcuuu ggcgggcaaa ggggauggcg augcgauaac     2880

ugucgccggc ccggcgguga accaaguccu gaggggacga caggacaguc uuauaaucag     2940

uacucccaga gauaucacca aaggaccaac acuaauguga acugccccau ugaauguuuc     3000

augccauugg acguccaggc cgaucgugag gacagccgcg aguga                     3045


<210>  1656
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG62013

<400>  1656
augagaguga ccugggcccc cccccccagc aucgaccuga ccaacuuccu ggugagauac       60

agccccguga agaacgagga ggacguggcc gagcugagca ucagccccag cgacaacgcc      120

guggugcuga ccaaccugcu gcccggcacc gaguacgugg ugagcgugag cagcguguac      180

gagcagcacg agagcacccc ccugagaggc agacagaaga ccggccugga cagccccacc      240

ggcaucgacu ucagcgacau caccggcaac agcuucaccg ugcacuggau cgcccccaga      300

gccaccauca ccggcuacag aaucagacac caccccgagc acuucagcgg cagacccaga      360

gaggacagag ugccccacag cagaaacagc aucacccuga ccaaccugac ccccggcacc      420

gaguacgugg ugagcaucgu ggcccugaac ggcagagagg agagcccccu gcugaucggc      480

cagcagagca ccgugagcga cgugcccaga gaccuggagg ugguggccgc cacccccacc      540

agccugcuga ucagcuggga cgcccccgcc gugaccguga gauacuacag aaucaccuac      600

ggcgagaccg gcggcaacag ccccgugcag gaguucaccg ugcccggcag caagagcacc      660

gccaccauca gcggccugaa gcccggcgug gacuacacca ucaccgugua cgccgugacc      720

ggcagaggcg acagccccgc cagcagcaag cccaucagca ucaacuacag aaccgagauc      780

gacaagccca gccagaugca ggugaccgac gugcaggaca acagcaucag cgugaagugg      840

cugcccagca gcagccccgu gaccggcuac agagugacca ccacccccaa gaacggcccc      900

ggccccacca agaccaagac cgccggcccc gaccagaccg agaugaccau cgagggccug      960

cagcccaccg uggaguacgu ggugagcgug uacgcccaga accccagcgg cgagagccag     1020

ccccuggugc agaccgccgu gaccaccauc cccgccccca ccgaccugaa guucacccag     1080

gugaccccca ccagccugag cgcccagugg acccccccca acgugcagcu gaccggcuac     1140

agagugagag ugacccccaa ggagaagacc ggccccauga aggagaucaa ccuggccccc     1200

gacagcagca gcgugguggu gagcggccug augguggcca ccaaguacga ggugagcgug     1260

uacgcccuga aggacacccu gaccagcaga cccgcccagg gcguggugac cacccuggag     1320

aacgugagcc cccccagaag agccagagug accgacgcca ccgagaccac caucaccauc     1380

agcuggagaa ccaagaccga gaccaucacc ggcuuccagg uggacgccgu gcccgccaac     1440

ggccagaccc ccauccagag aaccaucaag cccgacguga gaagcuacac caucaccggc     1500

cugcagcccg gcaccgacua caagaucuac cuguacaccc ugaacgacaa cgccagaagc     1560

agccccgugg ugaucgacgc cagcaccgcc aucgacgccc ccagcaaccu gagauuccug     1620

gccaccaccc ccaacagccu gcuggugagc uggcagcccc ccagagccag aaucaccggc     1680

uacaucauca aguacgagaa gcccggcagc ccccccagag agguggugcc cagacccaga     1740

cccggcguga ccgaggccac caucaccggc cuggagcccg gcaccgagua caccaucuac     1800

gugaucgccc ugaagaacaa ccagaagagc gagccccuga ucggcagaaa gaagaccgac     1860

gagcugcccc agcuggugac ccugccccac cccaaccugc acggccccga gauccuggac     1920

gugcccagca ccgugcagaa gacccccuuc gugacccacc ccggcuacga caccggcaac     1980

ggcauccagc ugcccggcac cagcggccag cagcccagcg ugggccagca gaugaucuuc     2040

gaggagcacg gcuucagaag aaccaccccc cccaccaccg ccacccccau cagacacaga     2100

cccagacccu acccccccaa cgugggcgag gagauccaga ucggccacau ccccagagag     2160

gacguggacu accaccugua cccccacggc cccggccuga accccaacgc cagcaccggc     2220

caggaggccc ugagccagac caccaucagc ugggcccccu uccaggacac cagcgaguac     2280

aucaucagcu gccaccccgu gggcaccgac gaggagcccc ugcaguucag agugcccggc     2340

accagcacca gcgccacccu gaccggccug accagaggcg ccaccuacaa caucaucgug     2400

gaggcccuga aggaccagca gagacacaag gugagagagg agguggugac cgugggcaac     2460

agcgugaacg agggccugaa ccagcccacc gacgacagcu gcuucgaccc cuacaccgug     2520

agccacuacg ccgugggcga cgagugggag agaaugagcg agagcggcuu caagcugcug     2580

ugccagugcc ugggcuucgg cagcggccac uucagaugcg acagcagcag auggugccac     2640

gacaacggcg ugaacuacaa gaucggcgag aagugggaca gacagggcga gaacggccag     2700

augaugagcu gcaccugccu gggcaacggc aagggcgagu ucaagugcga cccccacgag     2760

gccaccugcu acgacgacgg caagaccuac cacgugggcg agcaguggca gaaggaguac     2820

cugggcgcca ucugcagcug caccugcuuc ggcggccaga gaggcuggag augcgacaac     2880

ugcagaagac ccggcggcga gcccagcccc gagggcacca ccggccagag cuacaaccag     2940

uacagccaga gauaccacca gagaaccaac accaacguga acugccccau cgagugcuuc     3000

augccccugg acgugcaggc cgacagagag gacagcagag aguga                     3045


<210>  1657
<211>  3045
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG62013

<400>  1657
augagaguga ccugggcucc cccuccgagc aucgaccuga caaacuuccu cguccgguac       60

ucccccguua agaaugagga agauguggcc gagcugucua uuagcccuuc cgacaacgcc      120

gugguccuua cgaaucugcu ccccggcacc gaauaugugg uuucugugag cuccgucuac      180

gagcagcacg aaucuacacc ucugcgcggg agacagaaaa ccggacuuga uagccccaca      240

ggcaucgacu uuuccgauau uaccgggaac agcuucacag ugcauuggau cgcgccucgg      300

gcuaccauua cgggauaucg caucagacac cauccggagc acuuuucugg ccggccccgc      360

gaggacagag uuccucauuc ccggaauagc aucacccuga caaaccucac ccccgggaca      420

gaauacgugg ucucuauugu ggcccugaau ggacgcgagg aauccccucu gcucaucggc      480

caacagagca ccgugucuga uguccccaga gaccuggagg uuguggccgc uacgccgaca      540

ucccuucuga uuagcuggga ugccccugcu gugaccgucc gguauuaccg caucacauau      600

ggcgagaccg ggggaaacuc ccccgugcag gaguucaccg uuccuggcuc uaagagcaca      660

gccacgauuu ccgggcucaa acccggagug gacuacacca ucacagucua cgcggugacc      720

ggcagagggg auagccccgc cucuuccaag ccuauuagca ucaauuaucg gacagaaauc      780

gacaaaccgu cucaaaugca gguuaccgau gugcaggaca acagcauuuc cgucaagugg      840

cugcccucua gcuccccugu gacgggauac cgcgucacaa ccacccccaa gaauggcccu      900

ggccccacaa aaaccaagac agcugggccg gaccagacgg aaaugaccau cgagggacuu      960

caaccuacag uggaauaugu ugugagcguc uacgcccaga accccucugg cgagucccag     1020

ccucuggugc agaccgcugu uacaaccauu cccgccccua cggaucucaa auuuacccaa     1080

gugacaccca ccagccuguc ugcgcagugg acaccgccua auguccagcu gaccggguau     1140

agagugcggg ugacgcccaa ggagaaaaca ggacccauga aggaaaucaa ccucgccccu     1200

gacuccagcu ccguugucgu gucuggccug augguggcua ccaaguacga ggucagcgug     1260

uaugcccuua aagauacacu gaccuccaga ccggcucaag ggguugugac cacacucgaa     1320

aaugucucuc ccccucgccg ggccagagug acggacgcca ccgagacaac cauuacaauc     1380

agcuggcgca ccaagacgga aacaaucacc ggauuccagg uugaugcugu gcccgcgaac     1440

ggccagaccc cuauucagcg gacaaucaaa cccgacguca gauccuacac cauuacaggc     1500

cugcaaccug ggacggauua caagaucuau cuuuacaccc ugaacgacaa ugcccgcagc     1560

ucucccgugg uuauugaugc uuccacagcc aucgacgccc cgagcaaccu ccgguuucug     1620

gcuaccacac cuaauucucu gcucgugucc uggcagcccc cuagagcccg caucaccgga     1680

uauauuauca aauacgagaa gcccggcagc ccgccucggg aggucgugcc cagaccucgc     1740

cccgggguga cggaagcgac cauuacagga cuggagcccg gcaccgaaua uacaaucuac     1800

gucauugcuc uuaaaaacaa ucagaagucu gagccucuga ucgggcggaa gaaaaccgau     1860

gaacucccgc agcugguuac acuuccccac ccuaaccugc acggccccga gauucucgac     1920

gugccuagca ccgugcaaaa gacgcccuuc gucacacauc cuggauauga caccggcaau     1980

gggauccagc ugccgggaac cuccggccag cagcccagcg uggggcaaca gaugaucuuu     2040

gaggaacacg gauucagacg gacaaccccu cccacgacag ccaccccuau ucgccauaga     2100

ccccggccgu acccucccaa cguuggcgag gaaauccaga uugggcacau ccccagagag     2160

gauguggacu accaccugua uccucauggc cccggacuca auccuaacgc cucuacaggc     2220

caggaggcuc ugucccaaac cacaauuagc ugggccccgu uucaggauac cuccgaauac     2280

aucaucucuu gccaccccgu cgggacggac gaggaaccuc uucaguuccg cgugcccgga     2340

accagcacau ccgcuacccu gacaggccuc accagagggg ccacguauaa uauuaucguu     2400

gaggcgcuga aagaucaaca gcggcauaag gugcgcgaag aggucgugac aguuggaaac     2460

ucugugaaug agggccugaa ccagccuacc gacgauagcu guuuugaccc cuacacaguc     2520

ucccacuaug ccguggggga ugaaugggag agaaugucug aaagcggcuu caaacuucuc     2580

ugccaguguc ugggauucgg cuccgggcau uuucggugcg acagcucucg cuggugucac     2640

gauaauggag ugaacuacaa gauuggcgag aagugggaca gacaagggga aaacggacag     2700

augauguccu gcaccugucu gggcaauggg aaaggcgagu ucaagugcga uccgcacgag     2760

gcuaccuguu augacgacgg aaaaacauac caugucggcg aacaguggca gaaggaguac     2820

cucggggcca ucugcagcug uacgugcuuu ggaggccaac ggggguggcg cugcgauaac     2880

uguagacggc cuggaggcga acccucuccu gagggcacca cagggcaguc cuauaaucag     2940

uacagccagc gcuaucacca aagaaccaac acaaauguua acugccccau ugaauguuuc     3000

augccucugg acgugcaggc ugaucgggag gacucucgcg aguga                     3045


<210>  1658
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B4DU16

<400>  1658

Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr Asn Phe 
1               5                   10                  15      


Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala Glu Leu 
            20                  25                  30          


Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu Leu Pro 
        35                  40                  45              


Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln His Glu 
    50                  55                  60                  


Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser Pro Thr 
65                  70                  75                  80  


Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val His Trp 
                85                  90                  95      


Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His His Pro 
            100                 105                 110         


Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His Ser Arg 
        115                 120                 125             


Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr Val Val 
    130                 135                 140                 


Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu Ile Gly 
145                 150                 155                 160 


Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala 
                165                 170                 175     


Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr 
            180                 185                 190         


Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro 
        195                 200                 205             


Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
    210                 215                 220                 


Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr 
225                 230                 235                 240 


Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr 
                245                 250                 255     


Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp Val Gln 
            260                 265                 270         


Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro Val Thr 
        275                 280                 285             


Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro Thr Lys 
    290                 295                 300                 


Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu Gly Leu 
305                 310                 315                 320 


His Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn Pro Ser 
                325                 330                 335     


Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Thr Ile Pro Ala 
            340                 345                 350         


Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala 
        355                 360                 365             


Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val 
    370                 375                 380                 


Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro 
385                 390                 395                 400 


Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr 
                405                 410                 415     


Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala 
            420                 425                 430         


Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala 
        435                 440                 445             


Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr 
    450                 455                 460                 


Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn 
465                 470                 475                 480 


Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr 
                485                 490                 495     


Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr 
            500                 505                 510         


Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser 
        515                 520                 525             


Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro 
    530                 535                 540                 


Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly 
545                 550                 555                 560 


Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val 
                565                 570                 575     


Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu 
            580                 585                 590         


Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln 
        595                 600                 605             


Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Gly Gln Glu Ala Leu 
    610                 615                 620                 


Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr 
625                 630                 635                 640 


Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Phe 
                645                 650                 655     


Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg 
            660                 665                 670         


Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp Gln Gln Arg 
        675                 680                 685             


His Lys Val Arg Glu Glu Val Ile Thr Val Gly Asn Ser Val Asn Glu 
    690                 695                 700                 


Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr Thr Val 
705                 710                 715                 720 


Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser Glu Ser Gly 
                725                 730                 735     


Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly His Phe Arg 
            740                 745                 750         


Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn Tyr Lys Ile 
        755                 760                 765             


Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met Ser Cys 
    770                 775                 780                 


Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro His Glu 
785                 790                 795                 800 


Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu Gln Trp 
                805                 810                 815     


Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly 
            820                 825                 830         


Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro 
        835                 840                 845             


Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg 
    850                 855                 860                 


Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu Cys Phe 
865                 870                 875                 880 


Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser Arg Glu 
                885                 890                 


<210>  1659
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAG62178

<400>  1659
augcguguca ccugggcucc acccccaucc auugauuuaa ccaacuuccu ggugcguuac       60

ucaccuguga aaaaugagga agauguugca gaguugucaa uuucuccuuc agacaaugca      120

guggucuuaa caaaucuccu gccugguaca gaauauguag ugagugucuc cagugucuac      180

gaacaacaug agagcacacc ucuuagagga agacagaaaa caggucuuga uuccccaacu      240

ggcauugacu uuucugauau uacugccaac ucuuuuacug ugcacuggau ugcuccucga      300

gccaccauca cuggcuacag gauccgccau caucccgagc acuucagugg gagaccucga      360

gaagaucggg ugccccacuc ucggaauucc aucacccuca ccaaccucac uccaggcaca      420

gaguaugugg ucagcaucgu ugcucuuaau ggcagagagg aaagucccuu auugauuggc      480

caacaaucaa caguuucuga uguuccgagg gaccuggaag uuguugcugc gacccccacc      540

agccuacuga ucagcuggga ugcuccugcu gucacaguga gauauuacag gaucacuuac      600

ggagaaacag gaggaaauag cccuguccag gaguucacug ugccugggag caagucuaca      660

gcuaccauca gcggccuuaa accuggaguu gauuauacca ucacugugua ugcugucacu      720

ggccguggag acagccccgc aagcagcaag ccaauuucca uuaauuaccg aacagaaauu      780

gacaaaccau cccagaugca agugaccgau guucaggaca acagcauuag ugucaagugg      840

cugccuucaa guuccccugu uacugguuac agaguaacca ccacucccaa aaauggacca      900

ggaccaacaa aaacuaaaac ugcaggucca gaucaaacag aaaugacuau ugaaggcuug      960

caucccacag uggaguaugu gguuaguguc uaugcucaga auccaagcgg agagagucag     1020

ccucugguuc agacugcagu aaccacuauu ccugcaccaa cugaccugaa guucacucag     1080

gucacaccca caagccugag cgcccagugg acaccaccca auguucagcu cacuggauau     1140

cgagugcggg ugacccccaa ggagaagacc ggaccaauga aagaaaucaa ccuugcuccu     1200

gacagcucau ccgugguugu aucaggacuu augguggcca ccaaauauga agugaguguc     1260

uaugcucuua aggacacuuu gacaagcaga ccagcucagg guguugucac cacucuggag     1320

aaugucagcc caccaagaag ggcucgugug acagaugcua cugagaccac caucaccauu     1380

agcuggagaa ccaagacuga gacgaucacu ggcuuccaag uugaugccgu uccagccaau     1440

ggccagacuc caauccagag aaccaucaag ccagauguua gaagcuacac caucacaggu     1500

uuacaaccag gcacugacua caagaucuac cuguacaccu ugaaugacaa ugcucggagc     1560

uccccugugg ucaucgacgc cuccacugcc auugaugcac cauccaaccu gcguuuccug     1620

gccaccacac ccaauuccuu gcugguauca uggcagccgc cacgugccag gauuaccggc     1680

uacaucauca aguaugagaa gccugggucu ccucccagag aagugguccc ucggccccgc     1740

ccugguguca cagaggcuac uauuacuggc cuggaaccgg gaaccgaaua uacaauuuau     1800

gucauugccc ugaagaauaa ucagaagagc gagccccuga uuggaaggaa aaagacagga     1860

caagaagcuc ucucucagac aaccaucuca ugggccccau uccaggacac uucugaguac     1920

aucauuucau gucauccugu uggcacugau gaagaacccu uacaguucag gguuccugga     1980

acuucuacca gugccacucu gacaggccuc accagaggug ccaccuacaa caucauagug     2040

gaggcacuga aagaccagca gaggcauaag guucgggaag agguuauuac cgugggcaac     2100

ucugucaacg aaggcuugaa ccaaccuacg gaugacucgu gcuuugaccc cuacacaguu     2160

ucccauuaug ccguuggaga ugagugggaa cgaaugucug aaucaggcuu uaaacuguug     2220

ugccagugcu uaggcuuugg aaguggucau uucagaugug auucaucuag auggugccau     2280

gacaauggug ugaacuacaa gauuggagag aagugggacc gucagggaga aaauggccag     2340

augaugagcu gcacaugucu ugggaacgga aaaggagaau ucaaguguga cccucaugag     2400

gcaacguguu acgaugaugg gaagacauac cacguaggag aacaguggca gaaggaauau     2460

cucggugcca uuugcuccug cacaugcuuu ggaggccagc ggggcuggcg cugugacaac     2520

ugccgcagac cuggggguga acccaguccc gaaggcacua cuggccaguc cuacaaccag     2580

uauucucaga gauaccauca gagaacaaac acuaauguua auugcccaau ugagugcuuc     2640

augccuuuag auguacaggc ugacagagaa gauucccgag aguaa                     2685


<210>  1660
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAG62178

<400>  1660
augcgcguga ccugggcgcc cccgcccagc aucgaccuga ccaacuuccu cguccgguac       60

ucccccguga agaacgagga ggacguggcc gagcugagca ucucccccag cgacaacgcc      120

gucgugcuga cgaaccuccu gccgggcacc gaguacgugg ucuccgugag cuccguguac      180

gagcagcacg agagcacgcc ccugcgcggg cggcagaaga ccggccucga cucccccacc      240

gggaucgacu ucagcgacau caccgccaac uccuucaccg uccacuggau cgcgccccgc      300

gccaccauca cgggcuaccg gauccgccac cacccggagc acuucagcgg gcggccccgc      360

gaggaccggg ugccccacuc ccgcaacagc aucacccuga ccaaccugac ccccggcacg      420

gaguacgugg ucuccaucgu ggcccucaac ggccgggagg agagcccgcu gcugaucggg      480

cagcagucca ccgugagcga cgucccccgc gaccucgagg ugguggccgc cacccccacc      540

ucccugcuga ucagcuggga cgcccccgcc gucacggugc gguacuaccg caucaccuac      600

ggcgagaccg ggggcaacag cccggugcag gaguucaccg uccccggguc caagagcacg      660

gcgaccaucu ccggccucaa gcccggcgug gacuacacca ucaccgugua cgccgucacg      720

gggcggggcg acagccccgc cuccagcaag ccgaucucca ucaacuaccg caccgagauc      780

gacaagccca gccagaugca ggucaccgac guccaggaca acuccaucag cgugaagugg      840

cugcccucca gcucccccgu gaccggguac cgggucacga ccaccccgaa gaacggcccc      900

ggccccacca agacgaagac cgccgggccc gaccagaccg agaugaccau cgagggccug      960

cacccgacgg uggaguacgu ggugagcgug uacgcccaga accccuccgg ggagagccag     1020

ccccucgugc agaccgccgu caccaccauc ccggccccca ccgaccugaa guucacccag     1080

gugaccccca ccucccugag cgcccagugg acgcccccga acgugcagcu caccggcuac     1140

cgcguccggg ugacccccaa ggagaagacc gggcccauga aggagaucaa ccuggccccc     1200

gacuccagca gcguggucgu guccggccug augguggcca ccaaguacga ggucagcgug     1260

uacgcgcuca aggacacgcu gaccucccgc ccggcccagg gcguggucac cacccuggag     1320

aacgugagcc cgccccggcg cgcccgcgug acggacgcca ccgagaccac caucacgauc     1380

uccuggcgga ccaagaccga gaccaucacg ggguuccagg ucgacgccgu gcccgcgaac     1440

ggccagaccc cgauccagcg caccaucaag cccgacgugc ggagcuacac caucacgggg     1500

cuccagcccg gcaccgacua caagaucuac cuguacaccc ugaacgacaa cgcccgcucc     1560

agccccgucg ugaucgacgc cuccaccgcc aucgacgccc cgagcaaccu ccgguuccug     1620

gcgacgaccc ccaacucccu gcucgugagc uggcagccgc cccgcgcccg gaucaccggg     1680

uacaucauca aguacgagaa gcccggcucc ccgccccgcg aggucgugcc ccggccccgc     1740

cccggcguga ccgaggccac gaucaccggg cuggagcccg gcaccgagua caccaucuac     1800

gucaucgccc ugaagaacaa ccagaagucc gagccgcuca ucgggcggaa gaagacgggc     1860

caggaggcgc ugagccagac caccaucagc ugggcccccu uccaggacac cuccgaguac     1920

aucaucagcu gccaccccgu ggggaccgac gaggagcccc ugcaguuccg cgugccgggc     1980

acgagcaccu ccgccacccu caccggccug acgcgcgggg ccaccuacaa caucaucguc     2040

gaggcccuga aggaccagca gcggcacaag gugcgggagg aggugaucac cgucggcaac     2100

agcgugaacg aggggcucaa ccagcccacc gacgacuccu gcuucgaccc cuacacggug     2160

agccacuacg cggucggcga cgagugggag cgcauguccg agagcggcuu caagcugcug     2220

ugccagugcc ucggguucgg cuccgggcac uuccggugcg acagcucccg cuggugccac     2280

gacaacggcg ugaacuacaa gaucggggag aagugggacc ggcagggcga gaacggccag     2340

augaugagcu gcacgugccu ggggaacggc aagggggagu ucaagugcga cccccacgag     2400

gcgaccugcu acgacgacgg caagaccuac cacguggggg agcaguggca gaaggaguac     2460

cugggcgcca ucugcuccug cacgugcuuc ggcgggcagc gcggcuggcg cugcgacaac     2520

ugccggcgcc ccgggggcga gcccagcccc gaggggacca ccggccaguc cuacaaccag     2580

uacagccagc gguaccacca gcgcaccaac acgaacguca acugccccau cgagugcuuc     2640

augccgcucg acgugcaggc cgaccgggag gacucccgcg aguga                     2685


<210>  1661
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAG62178

<400>  1661
augcgcguca ccugggcccc cccccccucc aucgaccuca ccaacuuccu cguccgcuac       60

ucccccguca agaacgagga ggacgucgcc gagcucucca ucucccccuc cgacaacgcc      120

gucguccuca ccaaccuccu ccccggcacc gaguacgucg ucuccgucuc cuccgucuac      180

gagcagcacg aguccacccc ccuccgcggc cgccagaaga ccggccucga cucccccacc      240

ggcaucgacu ucuccgacau caccgccaac uccuucaccg uccacuggau cgccccccgc      300

gccaccauca ccggcuaccg cauccgccac caccccgagc acuucuccgg ccgcccccgc      360

gaggaccgcg ucccccacuc ccgcaacucc aucacccuca ccaaccucac ccccggcacc      420

gaguacgucg ucuccaucgu cgcccucaac ggccgcgagg aguccccccu ccucaucggc      480

cagcagucca ccgucuccga cgucccccgc gaccucgagg ucgucgccgc cacccccacc      540

ucccuccuca ucuccuggga cgcccccgcc gucaccgucc gcuacuaccg caucaccuac      600

ggcgagaccg gcggcaacuc ccccguccag gaguucaccg uccccggcuc caaguccacc      660

gccaccaucu ccggccucaa gcccggcguc gacuacacca ucaccgucua cgccgucacc      720

ggccgcggcg acucccccgc cuccuccaag cccaucucca ucaacuaccg caccgagauc      780

gacaagcccu cccagaugca ggucaccgac guccaggaca acuccaucuc cgucaagugg      840

cuccccuccu ccucccccgu caccggcuac cgcgucacca ccacccccaa gaacggcccc      900

ggccccacca agaccaagac cgccggcccc gaccagaccg agaugaccau cgagggccuc      960

caccccaccg ucgaguacgu cgucuccguc uacgcccaga accccuccgg cgagucccag     1020

ccccucgucc agaccgccgu caccaccauc cccgccccca ccgaccucaa guucacccag     1080

gucaccccca ccucccucuc cgcccagugg acccccccca acguccagcu caccggcuac     1140

cgcguccgcg ucacccccaa ggagaagacc ggccccauga aggagaucaa ccucgccccc     1200

gacuccuccu ccgucgucgu cuccggccuc auggucgcca ccaaguacga ggucuccguc     1260

uacgcccuca aggacacccu caccucccgc cccgcccagg gcgucgucac cacccucgag     1320

aacgucuccc ccccccgccg cgcccgcguc accgacgcca ccgagaccac caucaccauc     1380

uccuggcgca ccaagaccga gaccaucacc ggcuuccagg ucgacgccgu ccccgccaac     1440

ggccagaccc ccauccagcg caccaucaag cccgacgucc gcuccuacac caucaccggc     1500

cuccagcccg gcaccgacua caagaucuac cucuacaccc ucaacgacaa cgcccgcucc     1560

ucccccgucg ucaucgacgc cuccaccgcc aucgacgccc ccuccaaccu ccgcuuccuc     1620

gccaccaccc ccaacucccu ccucgucucc uggcagcccc cccgcgcccg caucaccggc     1680

uacaucauca aguacgagaa gcccggcucc cccccccgcg aggucguccc ccgcccccgc     1740

cccggcguca ccgaggccac caucaccggc cucgagcccg gcaccgagua caccaucuac     1800

gucaucgccc ucaagaacaa ccagaagucc gagccccuca ucggccgcaa gaagaccggc     1860

caggaggccc ucucccagac caccaucucc ugggcccccu uccaggacac cuccgaguac     1920

aucaucuccu gccaccccgu cggcaccgac gaggagcccc uccaguuccg cguccccggc     1980

accuccaccu ccgccacccu caccggccuc acccgcggcg ccaccuacaa caucaucguc     2040

gaggcccuca aggaccagca gcgccacaag guccgcgagg aggucaucac cgucggcaac     2100

uccgucaacg agggccucaa ccagcccacc gacgacuccu gcuucgaccc cuacaccguc     2160

ucccacuacg ccgucggcga cgagugggag cgcauguccg aguccggcuu caagcuccuc     2220

ugccagugcc ucggcuucgg cuccggccac uuccgcugcg acuccucccg cuggugccac     2280

gacaacggcg ucaacuacaa gaucggcgag aagugggacc gccagggcga gaacggccag     2340

augauguccu gcaccugccu cggcaacggc aagggcgagu ucaagugcga cccccacgag     2400

gccaccugcu acgacgacgg caagaccuac cacgucggcg agcaguggca gaaggaguac     2460

cucggcgcca ucugcuccug caccugcuuc ggcggccagc gcggcuggcg cugcgacaac     2520

ugccgccgcc ccggcggcga gcccuccccc gagggcacca ccggccaguc cuacaaccag     2580

uacucccagc gcuaccacca gcgcaccaac accaacguca acugccccau cgagugcuuc     2640

augccccucg acguccaggc cgaccgcgag gacucccgcg aguga                     2685


<210>  1662
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAG62178

<400>  1662
augagaguga ccugggcccc gccuccaagc aucgaccuga caaacuuccu cgucagguac       60

uccccgguua agaaugagga agauguggcu gagcuuucua uuucacccag ugacaacgca      120

guagugcuga cuaauuuguu accuggcacg gaauaugucg ugagcguuuc cucuguguac      180

gagcagcacg aaucgacccc acugcggggg cgccagaaaa caggacuaga uucacccacu      240

gguauagacu uuagcgauau caccgccaac aguuucacag uccauuggau ugcgccucga      300

gcuaccauca cuggcuaucg uauuagacac cauccagagc acuuuuccgg gaggccccgg      360

gaggaccgcg ugccucauuc uagaaauagc aucacacuca ccaaccugac gccaggaacu      420

gaauacguag uuuccauagu ggcccuuaau ggcagggagg aaucaccgcu guugaucggu      480

cagcagagua ccgucagcga ugugccccgg gaccucgagg uggucgcagc cacaccuacu      540

ucucugcuga uuuccuggga ugcuccagca guuaccgugc gcuauuaccg aaucacauau      600

ggggagaccg gaggcaacuc acccguacag gaguucacgg ugccuggcag caagaguacu      660

gccacaauuu cugggcucaa accaggaguc gacuacacca ucacugugua cgcuguuaca      720

gguagaggcg auucccccgc cagcucgaag ccgauaucua uuaauuauag gaccgaaauc      780

gacaaaccuu cccaaaugca agugacggau guccaggaca acucaauuag ugugaagugg      840

uuacccagcu ccucuccagu aaccggguac cggguuacaa cuaccccuaa gaauggaccc      900

ggcccaacaa aaacuaagac cgcggguccc gaccagacag aaaugaccau cgaggggcug      960

cacccuacug uggaauaugu cgugagcguc uacgcacaaa acccaucagg agagagucag     1020

ccgcuugugc agacggccgu uacaaccauc cccgcuccua cugauuugaa auuuacccag     1080

gugacaccaa ccucccugag cgcccaaugg acucccccua auguacagcu aacaggcuau     1140

cguguccgcg ugacgccaaa ggagaaaacc ggccccauga aggaaauuaa ccucgcaccg     1200

gacucuucaa guguuguggu cagcgggcug augguggcua cuaaguacga gguauccgug     1260

uaugcccuua aagauacacu gaccucuaga ccugcgcagg gaguugucac aacuuuggaa     1320

aaugugucgc cacccaggcg ggcccgagug accgacgcaa cggagaccac aauaacuauc     1380

agcuggcgca ccaagacaga aacuauuacc gguuuccaag ucgaugcugu uccugccaac     1440

ggccagacgc ccauccagag aacaauaaaa ccagacguga gguccuacac cauuacuggg     1500

cuccagccug gaacagauua caagaucuau cuguacaccu uaaacgacaa ugcucgguca     1560

agucccgugg uaaucgaugc cucuacugca auugacgccc caagcaaccu gcgcuuucuc     1620

gcuaccacac ccaauucccu ucuggucuca uggcaaccuc ccagagcgag gaucacgggc     1680

uauauuauaa aauacgagaa gccagguucu cccccucgug aggugguucc acggccccga     1740

ccugggguga ccgaagcaac uaucacaggc uuggagccgg gaaccgaaua uacaauuuac     1800

gucaucgccc uaaagaacaa ucagaaaagc gagccacuga ucggcagaaa gaaaacuggg     1860

caggaagcuc ucucccagac cacgauuagu ugggcccccu uccaagauac aagcgaguau     1920

auaaucucuu gccacccugu gggaaccgac gaggaaccac ugcaguuuag gguucccggu     1980

acuuccaccu cagcaacacu uacuggccug acccgcgggg ccacauacaa cauuaucgug     2040

gaggcuuuga aggaccagca gcggcauaaa guaagagaag aggucauuac ggugggaaau     2100

agugugaacg agggccucaa ucaaccuacc gaugacagcu guuucgaucc guacacuguc     2160

ucgcacuaug ccguugguga cgaaugggag aggauguccg aaucuggguu uaagcuguua     2220

ugccaguguc ugggcuucgg aagcggccau uuucgcugcg auucaagucg auggugucac     2280

gacaacgggg ugaauuacaa aaucggagag aagugggauc ggcaggguga aaacggccag     2340

augauguccu gcacaugucu agggaaugga aagggcgagu ucaaaugcga cccccacgag     2400

gcaaccuguu augaugacgg uaagacuuac cauguagggg aacaauggca gaaagaguau     2460

cucggcgcga uaugcucuug uacaugcuuc ggaggccagc guggguggag augcgauaac     2520

uguaggcgcc caggaggcga accuagcccc gaggguacca cggggcaauc cuacaaucag     2580

uauucacagc gguaccacca gagaacuaac accaacguga auugcccaau cgaauguuuu     2640

augccucugg acguccaagc ugauagggag gacagccgag aguga                     2685


<210>  1663
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAG62178

<400>  1663
augagaguga ccugggcccc cccccccagc aucgaccuga ccaacuuccu ggugagauac       60

agccccguga agaacgagga ggacguggcc gagcugagca ucagccccag cgacaacgcc      120

guggugcuga ccaaccugcu gcccggcacc gaguacgugg ugagcgugag cagcguguac      180

gagcagcacg agagcacccc ccugagaggc agacagaaga ccggccugga cagccccacc      240

ggcaucgacu ucagcgacau caccgccaac agcuucaccg ugcacuggau cgcccccaga      300

gccaccauca ccggcuacag aaucagacac caccccgagc acuucagcgg cagacccaga      360

gaggacagag ugccccacag cagaaacagc aucacccuga ccaaccugac ccccggcacc      420

gaguacgugg ugagcaucgu ggcccugaac ggcagagagg agagcccccu gcugaucggc      480

cagcagagca ccgugagcga cgugcccaga gaccuggagg ugguggccgc cacccccacc      540

agccugcuga ucagcuggga cgcccccgcc gugaccguga gauacuacag aaucaccuac      600

ggcgagaccg gcggcaacag ccccgugcag gaguucaccg ugcccggcag caagagcacc      660

gccaccauca gcggccugaa gcccggcgug gacuacacca ucaccgugua cgccgugacc      720

ggcagaggcg acagccccgc cagcagcaag cccaucagca ucaacuacag aaccgagauc      780

gacaagccca gccagaugca ggugaccgac gugcaggaca acagcaucag cgugaagugg      840

cugcccagca gcagccccgu gaccggcuac agagugacca ccacccccaa gaacggcccc      900

ggccccacca agaccaagac cgccggcccc gaccagaccg agaugaccau cgagggccug      960

caccccaccg uggaguacgu ggugagcgug uacgcccaga accccagcgg cgagagccag     1020

ccccuggugc agaccgccgu gaccaccauc cccgccccca ccgaccugaa guucacccag     1080

gugaccccca ccagccugag cgcccagugg acccccccca acgugcagcu gaccggcuac     1140

agagugagag ugacccccaa ggagaagacc ggccccauga aggagaucaa ccuggccccc     1200

gacagcagca gcgugguggu gagcggccug augguggcca ccaaguacga ggugagcgug     1260

uacgcccuga aggacacccu gaccagcaga cccgcccagg gcguggugac cacccuggag     1320

aacgugagcc cccccagaag agccagagug accgacgcca ccgagaccac caucaccauc     1380

agcuggagaa ccaagaccga gaccaucacc ggcuuccagg uggacgccgu gcccgccaac     1440

ggccagaccc ccauccagag aaccaucaag cccgacguga gaagcuacac caucaccggc     1500

cugcagcccg gcaccgacua caagaucuac cuguacaccc ugaacgacaa cgccagaagc     1560

agccccgugg ugaucgacgc cagcaccgcc aucgacgccc ccagcaaccu gagauuccug     1620

gccaccaccc ccaacagccu gcuggugagc uggcagcccc ccagagccag aaucaccggc     1680

uacaucauca aguacgagaa gcccggcagc ccccccagag agguggugcc cagacccaga     1740

cccggcguga ccgaggccac caucaccggc cuggagcccg gcaccgagua caccaucuac     1800

gugaucgccc ugaagaacaa ccagaagagc gagccccuga ucggcagaaa gaagaccggc     1860

caggaggccc ugagccagac caccaucagc ugggcccccu uccaggacac cagcgaguac     1920

aucaucagcu gccaccccgu gggcaccgac gaggagcccc ugcaguucag agugcccggc     1980

accagcacca gcgccacccu gaccggccug accagaggcg ccaccuacaa caucaucgug     2040

gaggcccuga aggaccagca gagacacaag gugagagagg aggugaucac cgugggcaac     2100

agcgugaacg agggccugaa ccagcccacc gacgacagcu gcuucgaccc cuacaccgug     2160

agccacuacg ccgugggcga cgagugggag agaaugagcg agagcggcuu caagcugcug     2220

ugccagugcc ugggcuucgg cagcggccac uucagaugcg acagcagcag auggugccac     2280

gacaacggcg ugaacuacaa gaucggcgag aagugggaca gacagggcga gaacggccag     2340

augaugagcu gcaccugccu gggcaacggc aagggcgagu ucaagugcga cccccacgag     2400

gccaccugcu acgacgacgg caagaccuac cacgugggcg agcaguggca gaaggaguac     2460

cugggcgcca ucugcagcug caccugcuuc ggcggccaga gaggcuggag augcgacaac     2520

ugcagaagac ccggcggcga gcccagcccc gagggcacca ccggccagag cuacaaccag     2580

uacagccaga gauaccacca gagaaccaac accaacguga acugccccau cgagugcuuc     2640

augccccugg acgugcaggc cgacagagag gacagcagag aguga                     2685


<210>  1664
<211>  2685
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAG62178

<400>  1664
augagaguga ccugggcucc cccuccgagc aucgaccuga caaacuuccu cguccgguac       60

ucccccguua agaaugagga agauguggcc gagcugucua uuagcccuuc cgacaacgcc      120

gugguccuua cgaaucugcu ccccggcacc gaauaugugg uuucugugag cuccgucuac      180

gagcagcacg aaucuacacc ucugcgcggg agacagaaaa ccggacuuga uagccccaca      240

ggcaucgacu uuuccgauau uaccgcgaac agcuucacag ugcauuggau cgcuccucgg      300

gccaccauua cgggguaucg caucagacac cauccggagc acuuuucugg acggccccgc      360

gaggacagag uuccucauuc ccggaauagc aucacccuga caaaccucac ccccggcaca      420

gaauacgugg ucucuauugu ggcccugaau gggcgcgagg aauccccucu gcucaucgga      480

caacagagca ccgugucuga uguccccaga gaccuggagg uuguggcugc cacgccgaca      540

ucccuucuga uuagcuggga ugcuccugcc gugaccgucc gguauuaccg caucacauau      600

ggcgagaccg gcgggaacuc ccccgugcag gaguucaccg uuccuggauc uaagagcaca      660

gcgacgauuu ccggccucaa acccggggug gacuacacca ucacagucua cgccgugacc      720

ggaagaggcg auagccccgc uucuuccaag ccuauuagca ucaauuaucg gacagaaauc      780

gacaaaccgu cucaaaugca gguuaccgau gugcaggaca acagcauuuc cgucaagugg      840

cugcccucua gcuccccugu gacgggguac cgcgucacaa ccacccccaa gaauggaccu      900

ggccccacaa aaaccaagac agccggcccg gaccagacgg aaaugaccau cgaggggcuu      960

cacccuacag uggaauaugu ugugagcguc uacgcucaaa accccucugg agagucccag     1020

ccucuggugc agaccgccgu uacaaccauu cccgcgccua cggaucucaa auuuacccag     1080

gugacaccca ccagccuguc ugcccaaugg acaccgccua auguccagcu gaccggcuau     1140

agagugcggg ugacgcccaa ggagaaaaca gggcccauga aggaaaucaa ccucgcuccu     1200

gacuccagcu ccguugucgu gucuggacug augguggcca ccaaguacga ggucagcgug     1260

uaugcucuua aagauacacu gaccuccaga ccggcccagg gcguugugac cacacucgaa     1320

aaugucucuc ccccucgccg ggccagagug acggacgcua ccgagacaac cauuacaauc     1380

agcuggcgca ccaagacgga aacaaucacc ggguuccaag uugaugcggu gcccgccaac     1440

ggacagaccc cuauucagcg gacaaucaaa cccgacguca gauccuacac cauuacaggc     1500

cugcagccug gcacggauua caagaucuau cuuuacaccc ugaacgacaa ugcucgcagc     1560

ucucccgugg uuauugaugc cuccacagcc aucgacgcuc cgagcaaccu ccgguuucug     1620

gccaccacac cuaauucucu gcucgugucc uggcaacccc cuagagcgcg caucaccggg     1680

uauauuauca aauacgagaa gcccggaagc ccgccucggg aggucgugcc cagaccucgc     1740

cccggcguga cggaagcuac cauuacaggg cuggagcccg gaaccgaaua uacaaucuac     1800

gucauugccc uuaaaaacaa ucagaagucu gagccucuga ucggccggaa gaaaaccggg     1860

caggaagccc ucagccagac aaccauuucc ugggcuccgu uccaagauac gagcgaguau     1920

aucaucucuu gccaccccgu uggcacagac gaggaaccuc ugcaguuuag agugcccgga     1980

accuccacca gcgccacacu uaccggccug acgcgcgggg cuacauacaa cauuaucgug     2040

gaggcccuca aggaccagca gcggcauaaa gucagagaag aggugauuac cguuggaaau     2100

uccgugaacg agggccugaa ucaaccuaca gaugacucuu guuucgaucc cuacaccguc     2160

agccacuaug cgguggggga cgaaugggag cggauguccg aaucuggauu uaagcugcuc     2220

ugccaguguc ugggcuucgg gagcggccau uuuagaugcg auuccucucg cuggugucac     2280

gacaacggag uuaauuacaa aaucggcgag aagugggauc ggcaggggga aaacggacag     2340

augaugagcu gcacaugucu uggcaauggg aagggagagu ucaaaugcga cccucacgag     2400

gccaccuguu augaugacgg caagacguac cauguggggg aacaauggca gaaagaguau     2460

cugggcgcua uuugcuccug uaccugcuuc ggaggccaga gaggguggcg cugcgauaac     2520

uguagacggc cgggaggcga acccagcccu gaggggacaa ccggacaauc uuacaaucag     2580

uauucccagc gcuaccacca gagaacaaac accaacguca auugccccau cgaauguuuu     2640

augccucucg acgugcaagc cgaucgggag gacagccgcg aguga                     2685


<210>  1665
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B7Z3W5

<400>  1665

Met Ala Ser Ala Phe Arg Leu Ser Leu Lys Pro Lys Val Ser Asp Asn 
1               5                   10                  15      


Met Thr His Leu Met Val Asp Phe Ser Gln Glu Arg Gln Met Leu Gln 
            20                  25                  30          


Thr Leu Lys Phe Leu Pro Val Pro Lys Ala Pro Glu Ile Asp Pro Val 
        35                  40                  45              


Glu Cys Leu Val Ala Asp Asn Ser Val Thr Val Ala Trp Arg Met Pro 
    50                  55                  60                  


Glu Glu Asp Asn Lys Ile Asp His Phe Ile Leu Glu His Arg Lys Thr 
65                  70                  75                  80  


Asn Phe Asp Gly Leu Pro Arg Val Lys Asp Glu Arg Cys Trp Glu Ile 
                85                  90                  95      


Ile Asp Asn Ile Lys Gly Thr Glu Tyr Thr Leu Ser Gly Leu Lys Phe 
            100                 105                 110         


Asp Ser Lys Tyr Met Asn Phe Arg Val Arg Ala Cys Asn Lys Ala Val 
        115                 120                 125             


Ala Gly Glu Tyr Ser Asp Pro Val Thr Leu Glu Thr Lys Ala Leu Asn 
    130                 135                 140                 


Phe Asn Leu Asp Asn Ser Ser Ser His Leu Asn Leu Lys Val Glu Asp 
145                 150                 155                 160 


Thr Cys Val Glu Trp Asp Pro Thr Gly Gly Lys Gly Gln Glu Ser Lys 
                165                 170                 175     


Ile Lys Gly Lys Glu Asn Lys Gly Ser Val His Val Thr Ser Leu Lys 
            180                 185                 190         


Lys His Thr Ser Gly Thr Pro Ser Pro Lys Arg Thr Ser Val Gly Ser 
        195                 200                 205             


Arg Pro Pro Ala Val Arg Gly Ser Arg Asp Arg Phe Thr Gly Glu Ser 
    210                 215                 220                 


Tyr Thr Val Leu Gly Asp Thr Ala Ile Glu Ser Gly Gln His Tyr Trp 
225                 230                 235                 240 


Glu Val Lys Ala Gln Lys Asp Cys Lys Ser Tyr Ser Val Gly Val Ala 
                245                 250                 255     


Tyr Lys Thr Leu Gly Lys Phe Asp Gln Leu Gly Lys Thr Asn Thr Ser 
            260                 265                 270         


Trp Cys Ile His Val Asn Asn Trp Leu Gln Asn Thr Phe Ala Ala Lys 
        275                 280                 285             


His Asn Asn Lys Val Lys Ala Leu Asp Val Thr Val Pro Glu Lys Ile 
    290                 295                 300                 


Gly Val Phe Cys Asp Phe Asp Gly Gly Gln Leu Ser Phe Tyr Asp Ala 
305                 310                 315                 320 


Asn Ser Lys Gln Leu Leu Tyr Ser Phe Lys Thr Lys Phe Thr Gln Pro 
                325                 330                 335     


Val Leu Pro Gly Phe Met Val Trp Cys Gly Gly Leu Ser Leu Ser Thr 
            340                 345                 350         


Gly Met Gln Val Pro Ser Ala Val Arg Thr Leu Gln Lys Ser Glu Asn 
        355                 360                 365             


Gly Met Thr Gly Ser Ala Ser Ser Leu Asn Asn Val Val Thr Gln 
    370                 375                 380             


<210>  1666
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAH12351

<400>  1666
auggcuucag ccuuucgccu uucuuugaaa ccaaagguca gugacaacau gacucauuua       60

augguggauu ucucacagga aagacagaug cugcaaacuu ugaaguuuuu gccagucccc      120

aaagcuccag agauagaucc aguagagugu uugguggcag auaacucugu aacaguggcu      180

uggagaaugc cagaagaaga uaauaagauu gaccauuuua uacuggaaca uaggaagacu      240

aauuuugaug gacuuccacg uguaaaggau gagcgaugcu gggagauaau ugauaauauu      300

aaggguacug aauauacacu aucaggcuua aaauuugauu caaaguauau gaauuucaga      360

gugcgagcuu guaacaaggc uguggcugga gaguauucug auccagugac ucuagagacc      420

aaagcacuua acuucaauuu ggauaacucc ucaucccauu ugaaccugaa aguugaagau      480

acauguguag agugggaucc uacuggagga aaaggucaag aaaguaaaau uaaaggaaaa      540

gagaacaagg gcagugucca uguuacuuca cugaagaaac auacaagugg uacaccaucc      600

ccaaaacgaa caucuguagg cuccaggcca ccagcaguaa gaggcaguag agaucguuuu      660

acuggagaau cauacacagu gcugggagac acugcuauug aaaguggaca acauuauugg      720

gaggucaagg cccagaagga uuguaaaucc uacagugugg gaguagcaua caaaacguug      780

gggaaauuug accaauuggg aaagacaaac acuaguuggu guauccaugu caacaacugg      840

cuacaaaaca cauuugcagc aaagcauaau aauaaaguca aagcuuugga uguuacuguu      900

ccugaaaaaa uagguguauu uugugauuuu gauggggguc aacuuucauu cuaugaugca      960

aauucuaaac aguugcuaua uuccuuuaag acaaaauuua cucagccagu acuaccuggu     1020

uucaugguau gguguggugg acuuucuuug aguacuggga ugcagguucc aagugcugug     1080

agaacacuuc agaaaaguga aaauggaaug acugguucag cuagcagccu gaacaauguu     1140

guuacucaau ag                                                         1152


<210>  1667
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAH12351

<400>  1667
auggccagcg ccuuccgccu gucccucaag cccaagguga gcgacaacau gacccaccug       60

auggucgacu ucucccagga gcggcagaug cugcagaccc ucaaguuccu gccggugccc      120

aaggcgcccg agaucgaccc cguggagugc cuggucgccg acaacagcgu gacgguggcc      180

uggcgcaugc cggaggagga caacaagauc gaccacuuca uccucgagca ccggaagacc      240

aacuucgacg gccugccccg cgucaaggac gagcggugcu gggagaucau cgacaacauc      300

aaggggaccg aguacacccu guccggccuc aaguucgaca gcaaguacau gaacuuccgc      360

gugcgggccu gcaacaaggc cguggcgggg gaguacuccg accccgucac gcuggagacc      420

aaggcccuga acuucaaccu cgacaacagc uccagccacc ugaaccugaa gguggaggac      480

acgugcgugg agugggaccc caccggcggg aagggccagg aguccaagau caagggcaag      540

gagaacaagg ggagcgucca cgugaccucc cucaagaagc acaccagcgg caccccgucc      600

cccaagcgca ccagcguggg gucccggccg cccgccgucc gcggcagccg ggaccgcuuc      660

acgggggagu ccuacaccgu gcugggcgac accgccaucg agagcggcca gcacuacugg      720

gaggugaagg cgcagaagga cugcaagagc uacuccgucg ggguggccua caagacccug      780

ggcaaguucg accagcucgg gaagacgaac accagcuggu gcauccacgu gaacaacugg      840

cugcagaaca ccuucgccgc caagcacaac aacaagguca aggcccugga cgugaccgug      900

cccgagaaga ucggcgucuu cugcgacuuc gacggcgggc agcucuccuu cuacgacgcg      960

aacagcaagc agcugcugua cuccuucaag acgaaguuca cccagcccgu gcuccccggc     1020

uucauggucu ggugcggggg ccugagccug uccaccggga ugcagguccc cagcgccgug     1080

cggacccucc agaaguccga gaacggcaug acgggcagcg ccuccagccu gaacaacgug     1140

gugacccagu ga                                                         1152


<210>  1668
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAH12351

<400>  1668
auggccuccg ccuuccgccu cucccucaag cccaaggucu ccgacaacau gacccaccuc       60

auggucgacu ucucccagga gcgccagaug cuccagaccc ucaaguuccu ccccgucccc      120

aaggcccccg agaucgaccc cgucgagugc cucgucgccg acaacuccgu caccgucgcc      180

uggcgcaugc ccgaggagga caacaagauc gaccacuuca uccucgagca ccgcaagacc      240

aacuucgacg gccucccccg cgucaaggac gagcgcugcu gggagaucau cgacaacauc      300

aagggcaccg aguacacccu cuccggccuc aaguucgacu ccaaguacau gaacuuccgc      360

guccgcgccu gcaacaaggc cgucgccggc gaguacuccg accccgucac ccucgagacc      420

aaggcccuca acuucaaccu cgacaacucc uccucccacc ucaaccucaa ggucgaggac      480

accugcgucg agugggaccc caccggcggc aagggccagg aguccaagau caagggcaag      540

gagaacaagg gcuccgucca cgucaccucc cucaagaagc acaccuccgg cacccccucc      600

cccaagcgca ccuccgucgg cucccgcccc cccgccgucc gcggcucccg cgaccgcuuc      660

accggcgagu ccuacaccgu ccucggcgac accgccaucg aguccggcca gcacuacugg      720

gaggucaagg cccagaagga cugcaagucc uacuccgucg gcgucgccua caagacccuc      780

ggcaaguucg accagcucgg caagaccaac accuccuggu gcauccacgu caacaacugg      840

cuccagaaca ccuucgccgc caagcacaac aacaagguca aggcccucga cgucaccguc      900

cccgagaaga ucggcgucuu cugcgacuuc gacggcggcc agcucuccuu cuacgacgcc      960

aacuccaagc agcuccucua cuccuucaag accaaguuca cccagcccgu ccuccccggc     1020

uucauggucu ggugcggcgg ccucucccuc uccaccggca ugcagguccc cuccgccguc     1080

cgcacccucc agaaguccga gaacggcaug accggcuccg ccuccucccu caacaacguc     1140

gucacccagu ga                                                         1152


<210>  1669
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAH12351

<400>  1669
auggccagcg cuuucagacu gucccucaag cccaaagugu cugacaacau gacccaccuu       60

auggucgauu uuucacagga gaggcaaaug cugcagacau ugaaguucuu accuguucca      120

aaagcaccgg aaaucgaccc cguggagugc cugguagccg auaauagugu gacugucgcg      180

uggcggaugc cugaagagga caacaagauu gaucauuuua uacuagaaca ccgcaaaacg      240

aauuucgacg gccucccacg agugaaggau gagcguuguu gggagaucau ugacaacauc      300

aaggggaccg aauacacacu gagcggacuu aaauuugauu ccaaguauau gaauuucaga      360

guuagggcuu gcaacaaagc cguggccggu gaguacucug accccgucac ucuggaaacc      420

aaggcauuga auuuuaaccu cgauaauucg ucaagccauc ugaaccugaa aguggaggac      480

acauguguag agugggaucc uaccggcggg aagggacagg aaaguaagau uaaaggcaag      540

gagaauaaag guuccguuca cgugacuucu cucaagaaac auacaagcgg gaccccaucc      600

cccaagcgga cgucagucgg aagucgcccu ccagcuguga gaggcagcag ggaccgguuc      660

acuggcgaau cuuauaccgu guuaggggac acagcaaucg aguccggaca gcacuacugg      720

gaagucaaag cccaaaagga uugcaaguca uauagcguug guguggcuua caaaacucug      780

ggcaaguuug accagcuugg gaaaaccaac acaaguuggu guauacacgu aaauaacugg      840

uugcagaaua ccuucgccgc gaagcauaac aacaaaguga aggcacugga ugucacggug      900

ccggagaaga ucggaguguu uugcgacuuc gauggcgguc agcuaucuuu uuaugacgcc      960

aauuccaaac aacuccugua cagcuucaag acuaaauuca cacagcccgu gcuuccuggg     1020

uuuauggucu gguguggagg ccugucguug ucuaccggca ugcagguucc auccgcugua     1080

cgcacucucc agaagucaga gaacgggaug acaggaagug ccagcucccu gaauaacguu     1140

gugacccaau ga                                                         1152


<210>  1670
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAH12351

<400>  1670
auggccagcg ccuucagacu gagccugaag cccaagguga gcgacaacau gacccaccug       60

augguggacu ucagccagga gagacagaug cugcagaccc ugaaguuccu gcccgugccc      120

aaggcccccg agaucgaccc cguggagugc cugguggccg acaacagcgu gaccguggcc      180

uggagaaugc ccgaggagga caacaagauc gaccacuuca uccuggagca cagaaagacc      240

aacuucgacg gccugcccag agugaaggac gagagaugcu gggagaucau cgacaacauc      300

aagggcaccg aguacacccu gagcggccug aaguucgaca gcaaguacau gaacuucaga      360

gugagagccu gcaacaaggc cguggccggc gaguacagcg accccgugac ccuggagacc      420

aaggcccuga acuucaaccu ggacaacagc agcagccacc ugaaccugaa gguggaggac      480

accugcgugg agugggaccc caccggcggc aagggccagg agagcaagau caagggcaag      540

gagaacaagg gcagcgugca cgugaccagc cugaagaagc acaccagcgg cacccccagc      600

cccaagagaa ccagcguggg cagcagaccc cccgccguga gaggcagcag agacagauuc      660

accggcgaga gcuacaccgu gcugggcgac accgccaucg agagcggcca gcacuacugg      720

gaggugaagg cccagaagga cugcaagagc uacagcgugg gcguggccua caagacccug      780

ggcaaguucg accagcuggg caagaccaac accagcuggu gcauccacgu gaacaacugg      840

cugcagaaca ccuucgccgc caagcacaac aacaagguga aggcccugga cgugaccgug      900

cccgagaaga ucggcguguu cugcgacuuc gacggcggcc agcugagcuu cuacgacgcc      960

aacagcaagc agcugcugua cagcuucaag accaaguuca cccagcccgu gcugcccggc     1020

uucauggugu ggugcggcgg ccugagccug agcaccggca ugcaggugcc cagcgccgug     1080

agaacccugc agaagagcga gaacggcaug accggcagcg ccagcagccu gaacaacgug     1140

gugacccagu ga                                                         1152


<210>  1671
<211>  1152
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAH12351

<400>  1671
auggccagcg cuuucagacu gucccucaag cccaaagugu cugacaacau gacccaccug       60

auggucgauu uuagccagga gcggcaaaug cuucagacac ugaaguuccu cccuguuccg      120

aaagcccccg aaaucgaccc uguggagugc cugguggcgg auaauuccgu cacgguggcu      180

uggcgcaugc ccgaagagga caacaagauu gaucauuuua uccuugaaca cagaaaaacc      240

aauuucgacg gccugccucg gguuaaggau gagcgcuguu gggagauuau cgacaacauu      300

aaggggacag aauacacccu cucuggacug aaauuugaua gcaaguauau gaauuucaga      360

gugcgggccu gcaacaaagc cgucgcuggc gaguacuccg accccgugac acuggaaacc      420

aaggcccuca auuuuaaccu ggauaauucu agcucccauc uuaaccugaa aguugaggac      480

acaugugugg agugggaucc uaccggggga aagggccagg aaagcaagau caaagggaag      540

gagaauaaag gaucugucca cgugacgucc cucaagaaac auaccagcgg cacaccgucu      600

cccaagcgca ccuccguggg cagcagaccu cccgcugucc gggggucucg cgacagauuc      660

acaggagaau ccuauaccgu ucugggcgac acggccaucg agagcgggca gcacuacugg      720

gaagugaaag cgcaaaagga uugcaagucc uauucugugg gagucgccua caaaacacuu      780

ggcaaguuug accagcuggg gaaaaccaac acaagcuggu guauucacgu gaauaacugg      840

cuccagaaua ccuucgcugc caagcauaac aacaaaguua aggcucugga ugugaccguc      900

ccugagaaga ucggaguguu uugcgacuuc gauggcggcc agcuguccuu uuaugacgcc      960

aauagcaaac aacuccugua cucuuucaag acaaaauuca cgcagcccgu ucuuccgggg     1020

uuuauggugu gguguggagg ccugucccuc agcaccggga ugcagguccc uucugcggug     1080

cggacacugc aaaagagcga gaacggaaug accggcuccg ccucuagccu uaauaacguc     1140

gugacacagu ga                                                         1152


<210>  1672
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__B7Z939

<400>  1672

Met Pro Pro Ser Lys Pro His Pro Pro Val Val Gly Lys Val Thr His 
1               5                   10                  15      


His Ser Ile Glu Leu Tyr Trp Asp Leu Glu Lys Lys Ala Lys Arg Gln 
            20                  25                  30          


Gly Pro Gln Glu Gln Trp Phe Arg Phe Ser Ile Glu Glu Glu Asp Pro 
        35                  40                  45              


Lys Met His Thr Tyr Gly Ile Ile Tyr Thr Gly Tyr Ala Thr Lys His 
    50                  55                  60                  


Val Val Glu Gly Leu Glu Pro Arg Thr Leu Tyr Arg Phe Arg Leu Lys 
65                  70                  75                  80  


Val Thr Ser Pro Ser Gly Glu Cys Glu Tyr Ser Pro Leu Val Ser Val 
                85                  90                  95      


Ser Thr Thr Ser Glu Tyr Ser Asp Arg Pro His Ser Pro Leu Ser Arg 
            100                 105                 110         


Ser Met Glu Met Thr Ser Asn Leu Glu Lys Ile Phe Cys Leu Ser Phe 
        115                 120                 125             


Gly Leu Thr Arg Ser Arg Asn Asp Thr Ile Phe Lys His Cys Asn Asn 
    130                 135                 140                 


Ile Cys 
145     


<210>  1673
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__BAH14175

<400>  1673
augccacccu caaagccuca uccaccuguc gugggcaaag ugacucauca cagcauugaa       60

uuauacuggg aucuggaaaa gaaagccaaa cgccaaggac cucaagagca gugguucagg      120

uucucgauug aagaagaaga ccccaaaaug cacacuuaug guaucauuua uacgggauau      180

gcaacgaagc auguuguuga aggucuggaa ccaaggacgc uguacagauu ucgccugaag      240

gucaccagcc ccucugggga gugugaguac agcccacucg ucucaguguc uacaaccagu      300

gaguauucag accguccaca cucaccucuc ucuagaucaa uggagaugac aagcaauuua      360

gaaaaaauau ucugccucuc guuuggccuu accagaagca gaaaugauac aauuuuuaaa      420

cacugcaaua auauuugcua g                                                441


<210>  1674
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__BAH14175

<400>  1674
augcccccga gcaagcccca cccgcccgug gucggcaagg ugacccacca cuccaucgag       60

cuguacuggg accucgagaa gaaggccaag cgccaggggc cccaggagca gugguuccgg      120

uucagcaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua cacgggguac      180

gccaccaagc acguggucga gggccuggag ccccgcaccc uguaccgguu ccgccucaag      240

gugaccuccc ccagcgggga gugcgaguac uccccgcugg ugagcgucuc cacgaccagc      300

gaguacuccg accggcccca cagcccccug ucccgcagca uggagaugac cuccaaccuc      360

gagaagaucu ucugccugag cuucggccug acccgguccc gcaacgacac gaucuucaag      420

cacugcaaca acaucugcug a                                                441


<210>  1675
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__BAH14175

<400>  1675
augccccccu ccaagcccca cccccccguc gucggcaagg ucacccacca cuccaucgag       60

cucuacuggg accucgagaa gaaggccaag cgccagggcc cccaggagca gugguuccgc      120

uucuccaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua caccggcuac      180

gccaccaagc acgucgucga gggccucgag ccccgcaccc ucuaccgcuu ccgccucaag      240

gucaccuccc ccuccggcga gugcgaguac uccccccucg ucuccgucuc caccaccucc      300

gaguacuccg accgccccca cuccccccuc ucccgcucca uggagaugac cuccaaccuc      360

gagaagaucu ucugccucuc cuucggccuc acccgcuccc gcaacgacac caucuucaag      420

cacugcaaca acaucugcug a                                                441


<210>  1676
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__BAH14175

<400>  1676
augcccccua gcaagccaca cccgcccgug gucggcaaag uuacccauca cuccaucgag       60

cuguacuggg accucgaaaa gaaagccaag agacaggggc cucaagagca gugguucagg      120

uuuucuauug aagaggaaga uccaaaaaug cauacauaug gaauaaucua cacugguuau      180

gcuacgaagc acgugguaga gggccuugag ccccggaccc uguaccgcuu ccgauugaag      240

gugacaucac cuagugggga augcgaguau agcccauuag ucuccguguc uacuaccucg      300

gaauacucag accgucccca uagcccucug aguagaucca uggagaugac aucuaaccua      360

gagaaaaucu uuugucucag cuucggacug accagguccc ggaaugauac uauuuuuaag      420

cacugcaaca auauuuguug a                                                441


<210>  1677
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__BAH14175

<400>  1677
augcccccca gcaagcccca cccccccgug gugggcaagg ugacccacca cagcaucgag       60

cuguacuggg accuggagaa gaaggccaag agacagggcc cccaggagca gugguucaga      120

uucagcaucg aggaggagga ccccaagaug cacaccuacg gcaucaucua caccggcuac      180

gccaccaagc acguggugga gggccuggag cccagaaccc uguacagauu cagacugaag      240

gugaccagcc ccagcggcga gugcgaguac agcccccugg ugagcgugag caccaccagc      300

gaguacagcg acagacccca cagcccccug agcagaagca uggagaugac cagcaaccug      360

gagaagaucu ucugccugag cuucggccug accagaagca gaaacgacac caucuucaag      420

cacugcaaca acaucugcug a                                                441


<210>  1678
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__BAH14175

<400>  1678
augcccccua gcaagccgca ucccccugug gucggcaaag uuacccacca cuccaucgag       60

cuguacuggg accucgaaaa gaaagccaag agacaggggc cccaagagca gugguuccgg      120

uuuucuauug aagaggaaga uccuaaaaug cauacauaug gaaucauuua cacgggcuau      180

gcuaccaagc acguggugga ggggcuggag ccccgcacac uuuacagauu ccggcugaag      240

gucaccagcc cuuccggaga augcgaguau ucuccgcucg ugagcguuuc cacaaccucu      300

gaauacagcg accgccccca uuccccucug agcagaucua uggagaugac auccaaccuu      360

gagaaaaucu uuugucugag cuucggccuc acccggucuc gcaaugauac gauuuuuaag      420

cacugcaaca auaucuguug a                                                441


<210>  1679
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__G5E9X3

<400>  1679

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser 
1               5                   10                  15      


Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln 
            20                  25                  30          


Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg 
        35                  40                  45              


Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro 
    50                  55                  60                  


Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly 
65                  70                  75                  80  


Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val 
                85                  90                  95      


Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His 
            100                 105                 110         


Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met 
        115                 120                 125             


Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly 
    130                 135                 140                 


Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr 
145                 150                 155                 160 


Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp 
                165                 170                 175     


Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp 
            180                 185                 190         


Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro 
        195                 200                 205             


Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly 
    210                 215                 220                 


Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser Gly 
225                 230                 235                 240 


Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys Asp 
                245                 250                 255     


Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys Pro 
            260                 265                 270         


Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser Pro 
        275                 280                 285             


Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro Glu 
    290                 295                 300                 


Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly Lys 
305                 310                 315                 320 


Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn Asp 
                325                 330                 335     


Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr Asn 
            340                 345                 350         


Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu Ser 
        355                 360                 365             


Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr Lys 
    370                 375                 380                 


Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser Lys 
385                 390                 395                 400 


Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly Glu 
                405                 410                 415     


Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr Lys 
            420                 425                 430         


Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn Asp 
        435                 440                 445             


Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser Gly 
    450                 455                 460                 


Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly Ile 
465                 470                 475                 480 


Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser Asp 
                485                 490                 495     


Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly Tyr 
            500                 505                 510         


Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val Lys 
        515                 520                 525             


Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr Asn 
    530                 535                 540                 


Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr Cys 
545                 550                 555                 560 


Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys Ile 
                565                 570                 575     


His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn Gly 
            580                 585                 590         


Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser Asn 
        595                 600                 605             


Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His Leu 
    610                 615                 620                 


Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr Cys 
625                 630                 635                 640 


Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val Gln 
                645                 650                 655     


Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln Gly 
            660                 665                 670         


Arg Pro Lys Ala Lys Glu Ile Gln Thr Pro Ser Gly 
        675                 680                 


<210>  1680
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__EAX08810

<400>  1680
auggcagaac auccaccacu acuggauaca acucagaucu uaaguaguga uauuucucuu       60

uugucugccc cuauuguaag ugcagaugga acacaacagg uuauucuggu acaaguuaac      120

ccaggagaag cauuuacaau aagaagagaa gauggacagu uucagugcau uacagguccu      180

gcucagguuc caaugauguc cccaaauggu ucugugccuc cuaucuaugu gccuccugga      240

uaugccccac agguuauuga agacaauggu guucgaagag uugucguggu cccucaggca      300

ccagaguuuc acccugguag ucacacaguu cuccaccguu cuccacaucc uccucuaccu      360

gguuucauuc cugucccaac uaugaugccg ccuccaccac gucauaugua cucacccgug      420

acuggagcug gagacaugac aacacaguau augccacagu aucagucuuc acaagucuau      480

ggagauguag augcucacuc uacacaugga agguccaacu uuagagauga acgaucuagu      540

aaaacauaug aacguuugca gaaaaaauug aaggaucgcc aaggaacaca gaaagauaaa      600

augagcaguc caccaucauc accccagaaa ugcccuucuc ccauuaauga acauaaugga      660

cuuauaaaag gacaaauugc uggugguaua aacacaggau cagcaaaaau caagucuggg      720

aaggggaaag gugguacaca aguugauaca gaaauugaag aaaaagauga agaaacuaaa      780

gcauuugaag cacuucuuuc caacauuguc aaaccagugg ccuccgacau ccaggcaagg      840

acaguaguac uuaccugguc accaccuucc agccucauua auggugaaac agaugaaagu      900

aguguaccag agcucuaugg uuaugaaguu cugaucucaa guacuggaaa agaugggaaa      960

uacaaaagug uauauguagg agaagaaaca aauaucacuu uaaaugaucu caagccagcc     1020

auggauuacc augcaaaagu ccaggcagaa uauaauucua uaaagggaac uccuucagag     1080

gcugaaaucu uuaccaccuu gagcugugaa ccugauauac cuaauccacc aaggauagcc     1140

aaucggacca aaaauucacu cacuuugcaa uggaaggcac cuagugacaa ugguucuaaa     1200

auccaaaacu uuguauuaga augggaugaa ggaaaaggaa auggagaauu uugucagugu     1260

uacaugggcu cacagaaaca auuuaaaauu acuaaacuuu caccagcaau gggcuguaaa     1320

uucagacuau cggccagaaa ugacuauggu acaagugguu uuagugaaga agucuuauau     1380

uacaccucag gcugugcucc uucuaugcca gcaaguccug uauuaaccaa ggcuggaauu     1440

acuugguuau ccuuacaaug gaguaagccc ucaggaacac caucagauga aggaauuucu     1500

uacauuuuag agauggagga agaaacuuca ggauaugguu uuaagccuaa auaugaugga     1560

gaagaucuug cuuacacagu gaaaaaucuc agacguagua cuaaguauaa auuuaagguu     1620

auugcuuaca acucagaagg uaaaaguaau ccaagugaag uaguagaauu uacuacuugc     1680

ccugauaaac caggcauacc uguaaagccu ucagugaaag gaaagauaca uucacacagu     1740

uuuaaaauaa ccugggaucc accaaaagac aauggcggag caaccaucaa uaaauaugua     1800

guggagaugg cagaagguuc uaacggaaac aaaugggaaa ugauauacag uggugcuacc     1860

agggaacauc uuugugaucg acugaaucca ggcuguuucu aucguuuacg aguuuacugc     1920

aucagugaug gaggacagag ugcggucucu gaaucuuuac uugugcagac uccagcugug     1980

ccuccuggcc caugccuccc ucccagauua caggguagac ccaaagcaaa agaaauacag     2040

acccccucug guuga                                                      2055


<210>  1681
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__EAX08810

<400>  1681
auggccgagc acccgccccu gcucgacacc acccagaucc ugagcuccga caucagccug       60

cucuccgccc ccaucgugag cgcggacggc acgcagcagg ucauccuggu ccaggugaac      120

cccggggagg ccuucaccau ccgccgggag gacggccagu uccagugcau caccgggccc      180

gcccaggugc cgaugauguc ccccaacggc agcgugccgc ccaucuacgu gccgcccggg      240

uacgcgcccc aggucaucga ggacaacggc gugcgccggg uggucguggu gccccaggcc      300

cccgaguucc accccggcuc ccacaccguc cugcaccgca gcccccaccc gccccucccc      360

ggguucaucc ccgugcccac gaugaugccg cccccgcccc ggcacaugua cucccccgug      420

accggcgccg gggacaugac cacccaguac augccccagu accagagcuc ccaggucuac      480

ggcgacgugg acgcccacag cacgcacggg cgcuccaacu uccgggacga gcgcagcucc      540

aagaccuacg agcggcugca gaagaagcug aaggaccgcc agggcaccca gaaggacaag      600

augagcuccc cgcccagcag cccccagaag ugccccuccc ccaucaacga gcacaacggc      660

cucaucaagg ggcagaucgc cggcgggauc aacaccggca gcgccaagau caaguccggc      720

aaggggaagg gcgggaccca gguggacacg gagaucgagg agaaggacga ggagaccaag      780

gcguucgagg cccugcugag caacaucguc aagccggugg ccuccgacau ccaggcccgg      840

accguggucc ucacguggag cccgcccucc agccugauca acggcgagac cgacgagucc      900

agcgugcccg agcuguacgg guacgaggug cucaucucca gcaccggcaa ggacggcaag      960

uacaaguccg ucuacguggg ggaggagacc aacaucacgc ugaacgaccu gaagcccgcc     1020

auggacuacc acgcgaaggu ccaggccgag uacaacagca ucaagggcac ccccuccgag     1080

gccgagaucu ucaccacccu cagcugcgag cccgacaucc ccaacccgcc ccgcaucgcc     1140

aaccggacga agaacucccu gacccugcag uggaaggccc ccagcgacaa cggguccaag     1200

auccagaacu ucgugcucga gugggacgag ggcaagggga acggcgaguu cugccagugc     1260

uacaugggca gccagaagca guucaagauc accaagcugu cccccgcgau ggggugcaag     1320

uuccgccuga gcgcccggaa cgacuacggc accagcgggu ucuccgagga ggugcucuac     1380

uacacgagcg gcugcgcccc guccaugccc gccagccccg uccugaccaa ggccgggauc     1440

accuggcugu cccuccagug gagcaagccc uccggcaccc cgagcgacga gggcaucucc     1500

uacauccugg agauggagga ggagacgagc ggguacggcu ucaagcccaa guacgacggg     1560

gaggaccugg cguacaccgu gaagaaccuc cgccggucca ccaaguacaa guucaaggug     1620

aucgccuaca acagcgaggg caaguccaac cccagcgagg ucguggaguu caccacgugc     1680

cccgacaagc cgggcauccc cgugaagccc uccgucaagg ggaagaucca cagccacucc     1740

uucaagauca ccugggaccc gcccaaggac aacggcgggg ccaccaucaa caaguacgug     1800

guggagaugg ccgagggcag caacgggaac aagugggaga ugaucuacag cggcgccacc     1860

cgcgagcacc ugugcgaccg gcugaacccc ggcugcuucu accgccuccg ggucuacugc     1920

aucuccgacg ggggccagag cgcggugucc gagagccugc uggugcagac ccccgccguc     1980

ccgcccgggc ccugccugcc cccgcgccuc cagggccgcc ccaaggccaa ggagauccag     2040

acgcccuccg gguga                                                      2055


<210>  1682
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__EAX08810

<400>  1682
auggccgagc accccccccu ccucgacacc acccagaucc ucuccuccga caucucccuc       60

cucuccgccc ccaucgucuc cgccgacggc acccagcagg ucauccucgu ccaggucaac      120

cccggcgagg ccuucaccau ccgccgcgag gacggccagu uccagugcau caccggcccc      180

gcccaggucc ccaugauguc ccccaacggc uccguccccc ccaucuacgu cccccccggc      240

uacgcccccc aggucaucga ggacaacggc guccgccgcg ucgucgucgu cccccaggcc      300

cccgaguucc accccggcuc ccacaccguc cuccaccgcu ccccccaccc cccccucccc      360

ggcuucaucc ccguccccac caugaugccc cccccccccc gccacaugua cucccccguc      420

accggcgccg gcgacaugac cacccaguac augccccagu accaguccuc ccaggucuac      480

ggcgacgucg acgcccacuc cacccacggc cgcuccaacu uccgcgacga gcgcuccucc      540

aagaccuacg agcgccucca gaagaagcuc aaggaccgcc agggcaccca gaaggacaag      600

auguccuccc cccccuccuc cccccagaag ugccccuccc ccaucaacga gcacaacggc      660

cucaucaagg gccagaucgc cggcggcauc aacaccggcu ccgccaagau caaguccggc      720

aagggcaagg gcggcaccca ggucgacacc gagaucgagg agaaggacga ggagaccaag      780

gccuucgagg cccuccucuc caacaucguc aagcccgucg ccuccgacau ccaggcccgc      840

accgucgucc ucaccugguc cccccccucc ucccucauca acggcgagac cgacgagucc      900

uccguccccg agcucuacgg cuacgagguc cucaucuccu ccaccggcaa ggacggcaag      960

uacaaguccg ucuacgucgg cgaggagacc aacaucaccc ucaacgaccu caagcccgcc     1020

auggacuacc acgccaaggu ccaggccgag uacaacucca ucaagggcac ccccuccgag     1080

gccgagaucu ucaccacccu cuccugcgag cccgacaucc ccaacccccc ccgcaucgcc     1140

aaccgcacca agaacucccu cacccuccag uggaaggccc ccuccgacaa cggcuccaag     1200

auccagaacu ucguccucga gugggacgag ggcaagggca acggcgaguu cugccagugc     1260

uacaugggcu cccagaagca guucaagauc accaagcucu cccccgccau gggcugcaag     1320

uuccgccucu ccgcccgcaa cgacuacggc accuccggcu ucuccgagga gguccucuac     1380

uacaccuccg gcugcgcccc cuccaugccc gccucccccg uccucaccaa ggccggcauc     1440

accuggcucu cccuccagug guccaagccc uccggcaccc ccuccgacga gggcaucucc     1500

uacauccucg agauggagga ggagaccucc ggcuacggcu ucaagcccaa guacgacggc     1560

gaggaccucg ccuacaccgu caagaaccuc cgccgcucca ccaaguacaa guucaagguc     1620

aucgccuaca acuccgaggg caaguccaac cccuccgagg ucgucgaguu caccaccugc     1680

cccgacaagc ccggcauccc cgucaagccc uccgucaagg gcaagaucca cucccacucc     1740

uucaagauca ccugggaccc ccccaaggac aacggcggcg ccaccaucaa caaguacguc     1800

gucgagaugg ccgagggcuc caacggcaac aagugggaga ugaucuacuc cggcgccacc     1860

cgcgagcacc ucugcgaccg ccucaacccc ggcugcuucu accgccuccg cgucuacugc     1920

aucuccgacg gcggccaguc cgccgucucc gagucccucc ucguccagac ccccgccguc     1980

ccccccggcc ccugccuccc cccccgccuc cagggccgcc ccaaggccaa ggagauccag     2040

acccccuccg gcuga                                                      2055


<210>  1683
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__EAX08810

<400>  1683
auggccgagc aucccccucu gcucgacacc acacagaucc uuagcuccga uauuucucug       60

uugucagcuc caauagugag ugcagacggc acucaacagg ucaucuuagu ucaggugaac      120

ccgggggaag ccuucacgau uagaagggag gauggacagu uucaaugcau caccgguccc      180

gcgcagguac cuaugaugag cccaaauggc uccgugcccc cuauuuacgu cccacccggg      240

uaugcuccuc aggugaucga agacaacgga guucggcgcg uggucguggu accacaggcc      300

ccggaguucc accccggcuc ucacacaguu cugcaucgau cgccucaccc accccuaccu      360

gguuuuauac cagugcccac uaugaugccg ccucccccac gucauaugua cucaccuguc      420

accggggcag gagauaugac aacccaauau augccccagu accagagcag ucagguguau      480

ggcgacgugg augcccacuc cacucacggc agaucuaauu ucagggacga acggagcucc      540

aagacauacg agcgccucca aaagaagcug aaagauagac aggggaccca gaaggacaaa      600

augucaaguc cacccagcuc uccucaaaag uguccauccc cgaucaacga gcauaaugga      660

cuuauuaagg gucagaucgc uggcgggauu aacacgggau cagcaaaaau caagagcggc      720

aaagguaaag ggggaacuca ggucgauacc gaaauagagg aaaaagacga ggagacaaag      780

gccuuugaag cucuguugag uaauauuguu aagcccgugg ccucugauau ccaggcgagg      840

acuguagugc ucaccugguc cccuccaagc ucgcugauua acggcgagac agacgaaucu      900

uccguccccg agcuguaugg cuacgaagug cucaucucaa guaccgggaa agacggaaag      960

uacaaaagcg uuuauguggg ugaggagacg aauaucacuu uaaacgaucu gaagccugca     1020

auggacuacc acgccaaagu ccaagcugaa uauaauucca uuaagggcac accaucugag     1080

gccgaaauau ucaccacucu uagcugcgag cccgauaucc cgaacccucc acggauugca     1140

aaucgcacca aaaacucauu gacacugcag uggaaggcuc ccagugacaa uggguccaag     1200

auccagaacu uugugcuaga augggaugag ggaaaaggca acggugaguu cugucagugc     1260

uacaugggga gccaaaagca guuuaaaaua acgaagcucu cuccugccau gggcuguaaa     1320

uuccgacugu cagcgagaaa ugacuaugga accaguggcu uuagcgaaga gguacuuuac     1380

uauacauccg ggugcgcccc cucuaugcca gcaucgccug uucugacuaa ggcuggaauu     1440

accugguuga gccuccagug guccaagccc ucagguacac caagugauga aggcaucucu     1500

uacauccugg agauggaaga ggagacuagc ggguacggau ucaaaccgaa guaugacggc     1560

gaagauuuag ccuacaccgu gaaaaaccug aggcggucca caaaguauaa auuuaagguc     1620

auugcuuaca auucagaggg uaagagcaac ccuucugaag uggucgaguu caccacuugu     1680

cccgacaaac cagggauccc cgugaagccu uccguuaaag gcaagauuca uagucacagc     1740

uucaaaauaa cgugggaucc acccaaggac aauggaggcg ccacaaucaa caaguaugug     1800

guagagaugg cagaaggguc uaauggaaac aaaugggaga ugauuuacuc cggugccacc     1860

cgugaacacc ucugcgaccg ccuuaauccu ggcuguuuuu auagacugag ggucuacugc     1920

aucucagaug ggggacagag ugcugugagc gagucguugc uaguucaaac uccggcggug     1980

ccacccggcc cuugucugcc accccggcuc cagggucgac cuaaggcaaa agaaauccag     2040

accccguccg gguga                                                      2055


<210>  1684
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__EAX08810

<400>  1684
auggccgagc accccccccu gcuggacacc acccagaucc ugagcagcga caucagccug       60

cugagcgccc ccaucgugag cgccgacggc acccagcagg ugauccuggu gcaggugaac      120

cccggcgagg ccuucaccau cagaagagag gacggccagu uccagugcau caccggcccc      180

gcccaggugc ccaugaugag ccccaacggc agcgugcccc ccaucuacgu gccccccggc      240

uacgcccccc aggugaucga ggacaacggc gugagaagag uggugguggu gccccaggcc      300

cccgaguucc accccggcag ccacaccgug cugcacagaa gcccccaccc cccccugccc      360

ggcuucaucc ccgugcccac caugaugccc ccccccccca gacacaugua cagccccgug      420

accggcgccg gcgacaugac cacccaguac augccccagu accagagcag ccagguguac      480

ggcgacgugg acgcccacag cacccacggc agaagcaacu ucagagacga gagaagcagc      540

aagaccuacg agagacugca gaagaagcug aaggacagac agggcaccca gaaggacaag      600

augagcagcc cccccagcag cccccagaag ugccccagcc ccaucaacga gcacaacggc      660

cugaucaagg gccagaucgc cggcggcauc aacaccggca gcgccaagau caagagcggc      720

aagggcaagg gcggcaccca gguggacacc gagaucgagg agaaggacga ggagaccaag      780

gccuucgagg cccugcugag caacaucgug aagcccgugg ccagcgacau ccaggccaga      840

accguggugc ugaccuggag cccccccagc agccugauca acggcgagac cgacgagagc      900

agcgugcccg agcuguacgg cuacgaggug cugaucagca gcaccggcaa ggacggcaag      960

uacaagagcg uguacguggg cgaggagacc aacaucaccc ugaacgaccu gaagcccgcc     1020

auggacuacc acgccaaggu gcaggccgag uacaacagca ucaagggcac ccccagcgag     1080

gccgagaucu ucaccacccu gagcugcgag cccgacaucc ccaacccccc cagaaucgcc     1140

aacagaacca agaacagccu gacccugcag uggaaggccc ccagcgacaa cggcagcaag     1200

auccagaacu ucgugcugga gugggacgag ggcaagggca acggcgaguu cugccagugc     1260

uacaugggca gccagaagca guucaagauc accaagcuga gccccgccau gggcugcaag     1320

uucagacuga gcgccagaaa cgacuacggc accagcggcu ucagcgagga ggugcuguac     1380

uacaccagcg gcugcgcccc cagcaugccc gccagccccg ugcugaccaa ggccggcauc     1440

accuggcuga gccugcagug gagcaagccc agcggcaccc ccagcgacga gggcaucagc     1500

uacauccugg agauggagga ggagaccagc ggcuacggcu ucaagcccaa guacgacggc     1560

gaggaccugg ccuacaccgu gaagaaccug agaagaagca ccaaguacaa guucaaggug     1620

aucgccuaca acagcgaggg caagagcaac cccagcgagg ugguggaguu caccaccugc     1680

cccgacaagc ccggcauccc cgugaagccc agcgugaagg gcaagaucca cagccacagc     1740

uucaagauca ccugggaccc ccccaaggac aacggcggcg ccaccaucaa caaguacgug     1800

guggagaugg ccgagggcag caacggcaac aagugggaga ugaucuacag cggcgccacc     1860

agagagcacc ugugcgacag acugaacccc ggcugcuucu acagacugag aguguacugc     1920

aucagcgacg gcggccagag cgccgugagc gagagccugc uggugcagac ccccgccgug     1980

ccccccggcc ccugccugcc ccccagacug cagggcagac ccaaggccaa ggagauccag     2040

acccccagcg gcuga                                                      2055


<210>  1685
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__EAX08810

<400>  1685
auggccgagc aucccccucu gcucgacacc acacagaucc ugagcuccga uauuucucuu       60

cugagcgcuc cgaucguguc cgccgacggc acgcaacagg ucauucucgu ucaggugaac      120

cccggggaag cguucaccau cagacgggag gauggacagu uucaaugcau uacaggcccu      180

gcucaggugc ccaugauguc uccuaauggg agcgugcccc cuaucuacgu cccgcccgga      240

uaugccccuc agguuaucga agacaacggc gugcgcagag ucgugguugu gccccaggcc      300

ccugaguucc accccggguc ccacaccguc cugcaucggu cuccgcaccc uccccuuccu      360

ggauuuauuc ccgugcccac aaugaugccu ccgcccccuc gccauaugua cagccccgug      420

accggcgcug gcgauaugac aacccaauau augccucagu accaguccag ccaggucuau      480

ggggacguug augcccacuc uacgcacgga agauccaauu uccgggacga acgcagcucu      540

aagaccuacg agagacugca aaagaagcuc aaagaucggc agggcacaca gaaggacaaa      600

auguccucuc ccccgagcuc cccucaaaag ugucccagcc cuaucaacga gcauaauggg      660

cugauuaagg gacagaucgc uggcgggauu aacaccggau ccgccaaaau caagucuggc      720

aaaggcaaag ggggaacaca gguggauacc gaaauugagg aaaaagacga ggagacgaag      780

gcguuugaag cccugcucag caauaucgug aagcccgucg cuuccgauau ccaggcccgc      840

acagugguuc ugaccuggag cccucccucu ucccuuauua acggcgagac agacgaaagc      900

ucugugccgg agcuguaugg guacgaaguc cucaucagcu ccaccggaaa agacggcaag      960

uacaaaucug uguauguugg ggaggagacc aauauuacac ugaacgaucu uaagccugcu     1020

auggacuacc acgccaaagu gcaagcggaa uauaauagca ucaagggaac gcccuccgag     1080

gccgaaauuu ucaccacacu gagcugcgag cccgauaucc cuaacccgcc cagaaucgcu     1140

aaucggacca aaaacucucu cacacugcag uggaaggccc cuuccgacaa uggcagcaag     1200

auucagaacu uuguccugga augggaugag ggcaaaggga acggagaguu cugucagugc     1260

uacaugggcu cucaaaagca guuuaaaauc accaagcucu cccccgcuau gggguguaaa     1320

uuccgccuga gcgccagaaa ugacuaugga acguccggcu uuucugaaga ggugcuuuac     1380

uauacaagcg ggugcgcccc uuccaugccc gcuucuccug uccugaccaa ggcgggcauu     1440

accuggcuca gccugcagug guccaagccc agcggaacac cgucugauga aggcaucucc     1500

uacauucuug agauggaaga ggagaccagc ggguacggau ucaaaccuaa guaugacggc     1560

gaagaucugg ccuacacagu gaaaaaccuc cggcgcucua cgaaguauaa auuuaagguu     1620

aucgcuuaca auuccgaggg aaagagcaac cccucugaag uggucgaguu caccacaugu     1680

ccugacaaac ccgggauccc ggugaagccu agcguuaaag gcaagauuca uucccacagc     1740

uucaaaauca ccugggaucc cccuaaggac aaugggggcg ccacaauuaa caaguaugug     1800

gucgagaugg ccgaaggauc uaauggcaac aaaugggaga ugaucuacuc cggggcuacc     1860

agagaacacc ugugcgaccg gcugaauccc ggauguuuuu auagacuccg cguguacugc     1920

auuagcgaug gcgggcaguc cgccgugucu gagagccugc uuguucaaac gcccgcgguc     1980

ccuccgggac ccugucugcc uccccggcuc cagggcagac cuaaggcuaa agaaauccag     2040

acccccuccg gguga                                                      2055


<210>  1686
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__Q9H382

<400>  1686

Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly 
1               5                   10                  15      


Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly 
            20                  25                  30          


Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly 
        35                  40                  45              


Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys 
    50                  55                  60                  


Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His 
65                  70                  75                  80  


Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys 
                85                  90                  95      


Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg 
            100                 105                 110         


Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn 
        115                 120                 125             


Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys 
    130                 135                 140                 


Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp 
145                 150                 155                 160 


Ser Arg Glu 
            


<210>  1687
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  fibronectin__Homo_sapiens__AAG35520

<400>  1687
augucugaau caggcuuuaa acuguugugc cagugcuuag gcuuuggaag uggucauuuc       60

agaugugauu caucuagaug gugccaugac aaugguguga acuacaagau uggagagaag      120

ugggaccguc agggagaaaa uggccagaug augagcugca caugucuugg gaacggaaaa      180

ggagaauuca agugugaccc ucaugaggca acguguuaug augaugggaa gacauaccac      240

guaggagaac aguggcagaa ggaauaucuc ggugccauuu gcuccugcac augcuuugga      300

ggccagcggg gcuggcgcug ugacaacugc cgcagaccug ggggugaacc cagucccgaa      360

ggcacuacug gccaguccua caaccaguau ucucagagau accaucagag aacaaacacu      420

aauguuaauu gcccaauuga gugcuucaug ccuuuagaug uacaggcuga cagagaagau      480

ucccgagagu aa                                                          492


<210>  1688
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       fibronectin__Homo_sapiens__AAG35520

<400>  1688
augagcgagu ccggcuucaa gcugcucugc cagugccugg gguucggcag cgggcacuuc       60

cgcugcgacu ccagccggug gugccacgac aacggcguga acuacaagau cggggagaag      120

ugggaccgcc agggcgagaa cggccagaug auguccugca cgugccuggg gaacggcaag      180

ggggaguuca agugcgaccc ccacgaggcg accugcuacg acgacggcaa gaccuaccac      240

gucggggagc aguggcagaa ggaguaccuc ggcgccaucu gcagcugcac gugcuucggc      300

gggcagcggg gcuggcgcug cgacaacugc cggcgccccg ggggcgagcc gucccccgag      360

ggcaccaccg ggcagagcua caaccaguac ucccagcggu accaccagcg caccaacacc      420

aacgugaacu gccccaucga gugcuucaug ccgcuggacg ugcaggccga ccgggaggac      480

agccgcgagu ga                                                          492


<210>  1689
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       fibronectin__Homo_sapiens__AAG35520

<400>  1689
auguccgagu ccggcuucaa gcuccucugc cagugccucg gcuucggcuc cggccacuuc       60

cgcugcgacu ccucccgcug gugccacgac aacggcguca acuacaagau cggcgagaag      120

ugggaccgcc agggcgagaa cggccagaug auguccugca ccugccucgg caacggcaag      180

ggcgaguuca agugcgaccc ccacgaggcc accugcuacg acgacggcaa gaccuaccac      240

gucggcgagc aguggcagaa ggaguaccuc ggcgccaucu gcuccugcac cugcuucggc      300

ggccagcgcg gcuggcgcug cgacaacugc cgccgccccg gcggcgagcc cucccccgag      360

ggcaccaccg gccaguccua caaccaguac ucccagcgcu accaccagcg caccaacacc      420

aacgucaacu gccccaucga gugcuucaug ccccucgacg uccaggccga ccgcgaggac      480

ucccgcgagu ga                                                          492


<210>  1690
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       fibronectin__Homo_sapiens__AAG35520

<400>  1690
augagcgagu ccggcuucaa gcugcucugc cagugucuug gguuuggauc uggucacuuc       60

agaugcgacu caaguaggug gugucaugau aacggcguga auuacaaaau cggggaaaag      120

ugggaccggc aaggagagaa cggccagaug augagcugca ccugucuggg uaaugggaaa      180

ggagaauuua agugcgaucc ccacgaggcc acauguuaug acgauggcaa aacuuaccau      240

gucggcgaac aguggcagaa ggaguauuug ggggcuauuu gcuccuguac gugcuucgga      300

ggucaacgcg gcuggcgaug ugacaacugc cguagaccug ggggagagcc aucuccggaa      360

ggcaccacag gucagucgua caaucaguau ucacagaggu accaccaacg gacuaacacc      420

aauguuaacu gccccauaga guguuuuaug ccuuuagaug ugcaggcaga ccgcgaagau      480

agcagagagu ga                                                          492


<210>  1691
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       fibronectin__Homo_sapiens__AAG35520

<400>  1691
augagcgaga gcggcuucaa gcugcugugc cagugccugg gcuucggcag cggccacuuc       60

agaugcgaca gcagcagaug gugccacgac aacggcguga acuacaagau cggcgagaag      120

ugggacagac agggcgagaa cggccagaug augagcugca ccugccuggg caacggcaag      180

ggcgaguuca agugcgaccc ccacgaggcc accugcuacg acgacggcaa gaccuaccac      240

gugggcgagc aguggcagaa ggaguaccug ggcgccaucu gcagcugcac cugcuucggc      300

ggccagagag gcuggagaug cgacaacugc agaagacccg gcggcgagcc cagccccgag      360

ggcaccaccg gccagagcua caaccaguac agccagagau accaccagag aaccaacacc      420

aacgugaacu gccccaucga gugcuucaug ccccuggacg ugcaggccga cagagaggac      480

agcagagagu ga                                                          492


<210>  1692
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       fibronectin__Homo_sapiens__AAG35520

<400>  1692
augagcgagu ccggcuucaa gcugcucugc cagugucugg gguuuggauc uggccacuuc       60

agaugcgaca gcucccggug gugucaugau aacgggguga auuacaaaau cggagaaaag      120

ugggaccgcc aaggcgagaa cgggcagaug augucuugca ccugucuugg aaauggcaaa      180

ggcgaauuua agugcgaucc ccacgaggcc acauguuaug acgaugggaa aacguaccau      240

gucggagaac aguggcagaa ggaguaucug ggcgcuauuu gcagcuguac cugcuucggg      300

ggacaaagag gcuggcggug ugacaacugc cgcagaccug ggggagagcc gucccccgaa      360

ggcacaaccg gccagucuua caaucaguau agccagcggu accaccaacg cacaaacacc      420

aauguuaacu gcccuaucga guguuuuaug ccccucgaug ugcaggccga cagagaagau      480

ucccgggagu ga                                                          492


<210>  1693
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FOS__Homo_sapiens__P01100

<400>  1693

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  1694
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FOS__Homo_sapiens__AAA52471

<400>  1694
augauguucu cgggcuucaa cgcagacuac gaggcgucau ccucccgcug cagcagcgcg       60

uccccggccg gggauagccu cucuuacuac cacucacccg cagacuccuu cuccagcaug      120

ggcucgccug ucaacgcgca ggacuucugc acggaccugg ccgucuccag ugccaacuuc      180

auucccacgg ucacugccau cucgaccagu ccggaccugc aguggcuggu gcagcccgcc      240

cucgucuccu cuguggcccc aucgcagacc agagccccuc acccuuucgg aguccccgcc      300

cccuccgcug gggcuuacuc cagggcuggc guugugaaga ccaugacagg aggccgagcg      360

cagagcauug gcaggagggg caagguggaa caguuaucuc cagaagaaga agagaaaagg      420

agaauccgaa gggaaaggaa uaagauggcu gcagccaaau gccgcaaccg gaggagggag      480

cugacugaua cacuccaagc ggagacagac caacuagaag augagaaguc ugcuuugcag      540

accgagauug ccaaccugcu gaaggagaag gaaaaacuag aguucauccu ggcagcucac      600

cgaccugccu gcaagauccc ugaugaccug ggcuucccag aagagauguc uguggcuucc      660

cuugaucuga cugggggccu gccagagguu gccaccccgg agucugagga ggccuucacc      720

cugccucucc ucaaugaccc ugagcccaag cccucagugg aaccugucaa gagcaucagc      780

agcauggagc ugaagaccga gcccuuugau gacuuccugu ucccagcauc auccaggccc      840

aguggcucug agacagcccg cuccgugcca gacauggacc uaucuggguc cuucuaugca      900

gcagacuggg agccucugca caguggcucc cuggggaugg ggcccauggc cacagagcug      960

gagccccugu gcacuccggu ggucaccugu acucccagcu gcacugcuua cacgucuucc     1020

uucgucuuca ccuaccccga ggcugacucc uuccccagcu gugcagcugc ccaccgcaag     1080

ggcagcagca gcaaugagcc uuccucugac ucgcucagcu cacccacgcu gcuggcccug     1140

uga                                                                   1143


<210>  1695
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FOS__Homo_sapiens__AAA52471

<400>  1695
augauguuca gcggcuucaa cgccgacuac gaggccucca gcucccgcug cagcuccgcg       60

agccccgccg gggacucccu gagcuacuac cacuccccgg ccgacagcuu cuccagcaug      120

ggcucccccg ugaacgccca ggacuucugc accgaccucg ccgucagcuc cgcgaacuuc      180

auccccaccg ugacggccau cagcaccucc cccgaccugc aguggcuggu gcagccggcc      240

cucgucagcu ccguggcccc cagccagacc cgggcgcccc accccuucgg ggugccggcc      300

cccagcgccg gcgccuacuc ccgcgccggg gucgugaaga ccaugacggg cggccgggcg      360

cagagcaucg ggcgccgggg caagguggag cagcuguccc ccgaggagga ggagaagcgc      420

cggauccgcc gggagcgcaa caagauggcc gccgccaagu gccggaaccg ccggcgcgag      480

cugaccgaca cccuccaggc cgagaccgac cagcuggagg acgagaaguc cgcgcugcag      540

acggagaucg ccaaccuccu gaaggagaag gagaagcugg aguucauccu cgccgcccac      600

cggcccgccu gcaagauccc ggacgaccug ggguuccccg aggagaugag cgucgcgagc      660

cuggaccuca ccggcgggcu gcccgaggug gccacccccg aguccgagga ggccuucacc      720

cugccgcucc ugaacgaccc cgagcccaag cccagcgugg agccggucaa guccaucagc      780

uccauggagc ugaagacgga gcccuucgac gacuuccucu uccccgccag cucccgcccc      840

agcggcuccg agaccgcccg gagcgugccg gacauggacc uguccggcag cuucuacgcg      900

gccgacuggg agccccugca cuccgggagc cucggcaugg ggcccauggc caccgagcug      960

gagccccugu gcaccccggu ggucacgugc acccccagcu gcaccgccua caccuccagc     1020

uucguguuca cguaccccga ggcggacucc uucccgagcu gcgccgccgc ccaccgcaag     1080

ggcuccagcu ccaacgagcc cagcuccgac agccucucca gccccacccu gcuggcccuc     1140

uga                                                                   1143


<210>  1696
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FOS__Homo_sapiens__AAA52471

<400>  1696
augauguucu ccggcuucaa cgccgacuac gaggccuccu ccucccgcug cuccuccgcc       60

ucccccgccg gcgacucccu cuccuacuac cacucccccg ccgacuccuu cuccuccaug      120

ggcucccccg ucaacgccca ggacuucugc accgaccucg ccgucuccuc cgccaacuuc      180

auccccaccg ucaccgccau cuccaccucc cccgaccucc aguggcucgu ccagcccgcc      240

cucgucuccu ccgucgcccc cucccagacc cgcgcccccc accccuucgg cguccccgcc      300

cccuccgccg gcgccuacuc ccgcgccggc gucgucaaga ccaugaccgg cggccgcgcc      360

caguccaucg gccgccgcgg caaggucgag cagcucuccc ccgaggagga ggagaagcgc      420

cgcauccgcc gcgagcgcaa caagauggcc gccgccaagu gccgcaaccg ccgccgcgag      480

cucaccgaca cccuccaggc cgagaccgac cagcucgagg acgagaaguc cgcccuccag      540

accgagaucg ccaaccuccu caaggagaag gagaagcucg aguucauccu cgccgcccac      600

cgccccgccu gcaagauccc cgacgaccuc ggcuuccccg aggagauguc cgucgccucc      660

cucgaccuca ccggcggccu ccccgagguc gccacccccg aguccgagga ggccuucacc      720

cucccccucc ucaacgaccc cgagcccaag cccuccgucg agcccgucaa guccaucucc      780

uccauggagc ucaagaccga gcccuucgac gacuuccucu uccccgccuc cucccgcccc      840

uccggcuccg agaccgcccg cuccgucccc gacauggacc ucuccggcuc cuucuacgcc      900

gccgacuggg agccccucca cuccggcucc cucggcaugg gccccauggc caccgagcuc      960

gagccccucu gcacccccgu cgucaccugc acccccuccu gcaccgccua caccuccucc     1020

uucgucuuca ccuaccccga ggccgacucc uuccccuccu gcgccgccgc ccaccgcaag     1080

ggcuccuccu ccaacgagcc cuccuccgac ucccucuccu cccccacccu ccucgcccuc     1140

uga                                                                   1143


<210>  1697
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FOS__Homo_sapiens__AAA52471

<400>  1697
augauguuca gcggcuuuaa cgccgacuac gaggcuuccu cuucaagaug caguagcgca       60

ucccccgccg gggauucucu gucguauuac cacagcccug cggacagcuu caguuccaug      120

ggaucuccag ugaaugcuca ggauuuuugu accgaccucg ccgucagcuc cgcaaacuuc      180

aucccgacag uuacugccau uucaacgagu cccgaucuuc aauggcuggu gcagccugcu      240

uugguaagcu cuguggcacc aucccagacc agggcucccc auccuuuugg ugucccagcc      300

cccucagccg gcgcguauag ccgggcaggg gugguuaaga caaugacugg aggccgcgcc      360

cagaguauag gucgacgugg gaaaguggaa caauuaucuc cugaggaaga ggaaaagaga      420

aggauccggc gcgagagaaa uaaaauggcu gccgcaaagu gcaggaaccg gcgccgagag      480

cugaccgaca cacuacaggc ugaaaccgau cagcucgagg acgaaaaauc cgcccugcag      540

acugagauug cgaaucuucu gaaggagaag gaaaaauugg aguucauccu cgccgcacac      600

agaccagcuu guaagauucc ggaugaccug ggauuucccg aagagaugag cgucgccucg      660

cuggaucuca caggcggcuu accugaagug gcuaccccag agucugagga agccuucacg      720

cugccccuuu ugaacgaccc ugagccaaaa cccuccguag aaccgguuaa gucaaucagu      780

agcauggagc ugaaaacuga accuuuugau gacuuccuau uucccgcauc cucuaggcca      840

agcgggucag agaccgcccg gagugugccu gacauggauc ucuccggauc auucuacgcu      900

gcggacuggg agccccugca uucugguuca cuuggcaugg ggccaauggc aacagaacug      960

gagcccuugu gcacuccugu cgugaccugu acaccaaguu gcaccgccua uacgagcucc     1020

uuuguguuca cuuacccgga agcugauucu uuccccucgu gugccgcagc ccaccguaag     1080

ggaagcuccu caaaugagcc uaguucugac agccucuccu caccaacacu guuagcucug     1140

uga                                                                   1143


<210>  1698
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FOS__Homo_sapiens__AAA52471

<400>  1698
augauguuca gcggcuucaa cgccgacuac gaggccagca gcagcagaug cagcagcgcc       60

agccccgccg gcgacagccu gagcuacuac cacagccccg ccgacagcuu cagcagcaug      120

ggcagccccg ugaacgccca ggacuucugc accgaccugg ccgugagcag cgccaacuuc      180

auccccaccg ugaccgccau cagcaccagc cccgaccugc aguggcuggu gcagcccgcc      240

cuggugagca gcguggcccc cagccagacc agagcccccc accccuucgg cgugcccgcc      300

cccagcgccg gcgccuacag cagagccggc guggugaaga ccaugaccgg cggcagagcc      360

cagagcaucg gcagaagagg caagguggag cagcugagcc ccgaggagga ggagaagaga      420

agaaucagaa gagagagaaa caagauggcc gccgccaagu gcagaaacag aagaagagag      480

cugaccgaca cccugcaggc cgagaccgac cagcuggagg acgagaagag cgcccugcag      540

accgagaucg ccaaccugcu gaaggagaag gagaagcugg aguucauccu ggccgcccac      600

agacccgccu gcaagauccc cgacgaccug ggcuuccccg aggagaugag cguggccagc      660

cuggaccuga ccggcggccu gcccgaggug gccacccccg agagcgagga ggccuucacc      720

cugccccugc ugaacgaccc cgagcccaag cccagcgugg agcccgugaa gagcaucagc      780

agcauggagc ugaagaccga gcccuucgac gacuuccugu uccccgccag cagcagaccc      840

agcggcagcg agaccgccag aagcgugccc gacauggacc ugagcggcag cuucuacgcc      900

gccgacuggg agccccugca cagcggcagc cugggcaugg gccccauggc caccgagcug      960

gagccccugu gcacccccgu ggugaccugc acccccagcu gcaccgccua caccagcagc     1020

uucguguuca ccuaccccga ggccgacagc uuccccagcu gcgccgccgc ccacagaaag     1080

ggcagcagca gcaacgagcc cagcagcgac agccugagca gccccacccu gcuggcccug     1140

uga                                                                   1143


<210>  1699
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FOS__Homo_sapiens__AAA52471

<400>  1699
augauguuca gcggcuuuaa cgccgacuac gaggcuuccu cuagcagaug cuccucugcc       60

agccccgcgg gggauucccu gucuuauuac cacagcccug cugacuccuu cagcucuaug      120

ggauccccgg ugaaugccca ggauuuuugu accgaccucg ccgucagcuc ugcuaacuuc      180

auccccacag uuacggccau uuccaccagc ccugaucugc aauggcuugu gcagcccgcu      240

cuggugucuu ccgucgcccc uagccagaca cgggcgcccc auccuuuugg cgugccggcc      300

cccuccgcug gggccuauuc ucgcgcugga guugugaaga ccaugacagg cgggagagcc      360

cagagcaucg gacggcgcgg caaagucgaa caacucuccc cugaggaaga ggaaaagaga      420

cggauucgca gagagcggaa uaaaauggcg gccgcuaagu gccgcaacag acggcgcgag      480

cugaccgaca cacuucaggc cgaaaccgau cagcuggagg acgagaaaag cgcucuccag      540

acggaaaucg ccaaucugcu gaaggagaag gaaaaacucg aguucauucu ggccgcucac      600

agacccgcgu guaagauccc ugaugaccuu ggcuuucccg aagagauguc uguggccucc      660

cuggaucuca ccgggggacu gccggaaguu gcuacaccug agagcgagga agccuucacc      720

cuuccccugc ucaacgaccc ugagcccaaa cccucugugg aaccugucaa gagcaucucc      780

ucuauggagc ugaaaacaga accguuugau gacuuccugu uucccgccag cucccggccu      840

agcggcucug agaccgcucg cuccgugccc gacauggauc ucagcggguc uuucuacgcc      900

gcggacuggg agccucugca uuccggaagc cuuggcaugg ggcccauggc uacggaacug      960

gagccgcucu gcacaccugu ggucaccugu acacccuccu gcaccgccua uaccucuagc     1020

uuuguuuuca cauacccuga agccgauucc uuccccucuu gugcugccgc ucacagaaag     1080

ggaagcucca gcaaugagcc uucuuccgac agccugucuu cccccacgcu ucuggcccuc     1140

uga                                                                   1143


<210>  1700
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FOXP3__Homo_sapiens__Q9BZS1

<400>  1700

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  1701
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FOXP3__Homo_sapiens__AAG53607

<400>  1701
augcccaacc ccaggccugg caagcccucg gccccuuccu uggcccuugg cccaucccca       60

ggagccucgc ccagcuggag ggcugcaccc aaagccucag accugcuggg ggcccggggc      120

ccagggggaa ccuuccaggg ccgagaucuu cgaggcgggg cccaugccuc cucuucuucc      180

uugaacccca ugccaccauc gcagcugcag cugcccacac ugccccuagu caugguggca      240

cccuccgggg cacggcuggg ccccuugccc cacuuacagg cacuccucca ggacaggcca      300

cauuucaugc accagcucuc aacgguggau gcccacgccc ggaccccugu gcugcaggug      360

cacccccugg agagcccagc caugaucagc cucacaccac ccaccaccgc cacugggguc      420

uucucccuca aggcccggcc uggccuccca ccugggauca acguggccag ccuggaaugg      480

guguccaggg agccggcacu gcucugcacc uucccaaauc ccagugcacc caggaaggac      540

agcacccuuu cggcugugcc ccagagcucc uacccacugc uggcaaaugg ugucugcaag      600

uggcccggau gugagaaggu cuucgaagag ccagaggacu uccucaagca cugccaggcg      660

gaccaucuuc uggaugagaa gggcagggca caaugucucc uccagagaga gaugguacag      720

ucucuggagc agcagcuggu gcuggagaag gagaagcuga gugccaugca ggcccaccug      780

gcugggaaaa uggcacugac caaggcuuca ucuguggcau cauccgacaa gggcuccugc      840

ugcaucguag cugcuggcag ccaaggcccu gucgucccag ccuggucugg cccccgggag      900

gccccugaca gccuguuugc uguccggagg caccuguggg guagccaugg aaacagcaca      960

uucccagagu uccuccacaa cauggacuac uucaaguucc acaacaugcg acccccuuuc     1020

accuacgcca cgcucauccg cugggccauc cuggaggcuc cagagaagca gcggacacuc     1080

aaugagaucu accacugguu cacacgcaug uuugccuucu ucagaaacca uccugccacc     1140

uggaagaacg ccauccgcca caaccugagu cugcacaagu gcuuugugcg gguggagagc     1200

gagaaggggg cuguguggac cguggaugag cuggaguucc gcaagaaacg gagccagagg     1260

cccagcaggu guuccaaccc uacaccuggc cccuga                               1296


<210>  1702
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FOXP3__Homo_sapiens__AAG53607

<400>  1702
augcccaacc cgcgccccgg caagcccagc gcccccuccc uggcccucgg gccgagcccc       60

ggcgcguccc ccagcuggcg ggccgccccc aaggccuccg accugcuggg ggcccgcggc      120

cccgggggca ccuuccaggg ccgggaccuc cgcgggggcg cgcacgccag cuccagcucc      180

cugaacccca ugccgcccag ccagcugcag cucccgaccc ugccccuggu gauggucgcc      240

cccuccgggg cccggcucgg cccccugccg caccuccagg cgcugcugca ggaccgcccc      300

cacuucaugc accagcugag cacgguggac gcccacgccc ggacccccgu gcuccagguc      360

cacccccugg aguccccggc caugaucagc cugaccccgc ccaccacggc caccggggug      420

uucucccuca aggcgcgccc cggccugccg cccggcauca acguggccag ccuggagugg      480

gucucccggg agcccgcccu ccugugcacc uuccccaacc ccagcgcgcc ccgcaaggac      540

uccacccuga gcgccgugcc ccagagcucc uacccgcucc uggccaacgg ggugugcaag      600

uggcccggcu gcgagaaggu cuucgaggag cccgaggacu uccugaagca cugccaggcc      660

gaccaccucc uggacgagaa ggggcgggcc cagugccugc uccagcgcga gauggugcag      720

agccuggagc agcagcuggu gcucgagaag gagaagcugu ccgccaugca ggcccaccug      780

gcgggcaaga uggcccucac gaaggccagc uccgucgcca gcuccgacaa gggcagcugc      840

ugcaucgugg ccgcgggguc ccagggcccc guggucccgg ccuggagcgg gccccgggag      900

gcccccgacu cccuguucgc cgugcgccgg caccuguggg gcagccacgg gaacuccacc      960

uuccccgagu uccuccacaa cauggacuac uucaaguucc acaacaugcg cccgcccuuc     1020

accuacgcga cccugauccg gugggccauc cuggaggccc ccgagaagca gcgcacgcuc     1080

aacgagaucu accacugguu cacccggaug uucgccuucu uccgcaacca ccccgccacc     1140

uggaagaacg cgauccggca caaccugagc cugcacaagu gcuucgugcg cgucgagucc     1200

gagaagggcg ccguguggac cguggacgag cucgaguucc gcaagaagcg gagccagcgc     1260

ccgucccggu gcagcaaccc cacgcccggc cccuga                               1296


<210>  1703
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FOXP3__Homo_sapiens__AAG53607

<400>  1703
augcccaacc cccgccccgg caagcccucc gcccccuccc ucgcccucgg ccccuccccc       60

ggcgccuccc ccuccuggcg cgccgccccc aaggccuccg accuccucgg cgcccgcggc      120

cccggcggca ccuuccaggg ccgcgaccuc cgcggcggcg cccacgccuc cuccuccucc      180

cucaacccca ugccccccuc ccagcuccag cuccccaccc ucccccucgu cauggucgcc      240

cccuccggcg cccgccucgg cccccucccc caccuccagg cccuccucca ggaccgcccc      300

cacuucaugc accagcucuc caccgucgac gcccacgccc gcacccccgu ccuccagguc      360

cacccccucg agucccccgc caugaucucc cucacccccc ccaccaccgc caccggcguc      420

uucucccuca aggcccgccc cggccucccc cccggcauca acgucgccuc ccucgagugg      480

gucucccgcg agcccgcccu ccucugcacc uuccccaacc ccuccgcccc ccgcaaggac      540

uccacccucu ccgccguccc ccaguccucc uacccccucc ucgccaacgg cgucugcaag      600

uggcccggcu gcgagaaggu cuucgaggag cccgaggacu uccucaagca cugccaggcc      660

gaccaccucc ucgacgagaa gggccgcgcc cagugccucc uccagcgcga gaugguccag      720

ucccucgagc agcagcucgu ccucgagaag gagaagcucu ccgccaugca ggcccaccuc      780

gccggcaaga uggcccucac caaggccucc uccgucgccu ccuccgacaa gggcuccugc      840

ugcaucgucg ccgccggcuc ccagggcccc gucguccccg ccugguccgg cccccgcgag      900

gcccccgacu cccucuucgc cguccgccgc caccucuggg gcucccacgg caacuccacc      960

uuccccgagu uccuccacaa cauggacuac uucaaguucc acaacaugcg cccccccuuc     1020

accuacgcca cccucauccg cugggccauc cucgaggccc ccgagaagca gcgcacccuc     1080

aacgagaucu accacugguu cacccgcaug uucgccuucu uccgcaacca ccccgccacc     1140

uggaagaacg ccauccgcca caaccucucc cuccacaagu gcuucguccg cgucgagucc     1200

gagaagggcg ccgucuggac cgucgacgag cucgaguucc gcaagaagcg cucccagcgc     1260

cccucccgcu gcuccaaccc cacccccggc cccuga                               1296


<210>  1704
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FOXP3__Homo_sapiens__AAG53607

<400>  1704
augcccaacc cuagaccagg caagccgagc gcccccuccc uggcucucgg gccuucucca       60

ggagcaucac ccaguuggag ggccgcgccu aaagcuagcg accuucuggg ugcccggggc      120

ccagggggaa ccuuccaggg ccgcgauuug cgaggugggg cacacgccuc cucuucguca      180

uuaaauccca ugccuccaag ccaacugcag cuaccgacac ucccccuggu gauggucgcu      240

ccuaguggag cacgucuugg cccacugccc cauuugcagg cccuccugca ggacagaccu      300

cacuuuaugc aucaacuguc cacuguugau gcucacgcca ggacgccagu gcuccaggua      360

caucccuuag aaucuccggc gaugaucagc cugaccccuc ccacaacugc aaccggcgug      420

uucucccuua aggcccggcc aggguugccu cccggaauua acgucgcuuc acuggaaugg      480

gugagucgcg agccagcccu acucugcaca uuucccaauc cuagcgcacc aagaaaagac      540

ucuacccugu ccgcuguucc gcagucaagc uacccccuuc uggccaacgg uguguguaag      600

uggccuggcu gcgaaaaagu cuucgaggaa ccagaggauu ucuugaagca cugucaggcg      660

gaccaccucc uggaugagaa ggggagggcc caaugcuuac ugcagcggga aauggugcag      720

agucucgagc agcaacuugu acuggaaaaa gagaaguugu cugcaaugca ggcucaucua      780

gccggaaaaa uggcucugac uaaggccucc agcguugcau cgucugacaa aggcuccugu      840

ugcauagugg ccgcugguuc acaggggccc gucgugccug cguggagugg accacgcgag      900

gcacccgaua gccucuucgc cgugcgaaga caccuguggg gcucccaugg caauucuaca      960

uuuccggaau uucuucacaa cauggacuau uuuaaguucc acaauaugag gccuccauuu     1020

accuacgcua cgcugauccg gugggccauu uuggaggcac ccgaaaagca acguacucuc     1080

aacgagaucu aucauugguu cacccgcaug uuugccuucu ucagaaauca cccugcuaca     1140

uggaaaaacg ccauuaggca uaaucugagc uuacacaagu guuuuguccg gguugaauca     1200

gagaaagggg caguguggac uguagaugag cuggaguucc gaaagaaacg cagucagaga     1260

cccuccaggu gcagcaaccc aaccccugga cccuga                               1296


<210>  1705
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FOXP3__Homo_sapiens__AAG53607

<400>  1705
augcccaacc ccagacccgg caagcccagc gcccccagcc uggcccuggg ccccagcccc       60

ggcgccagcc ccagcuggag agccgccccc aaggccagcg accugcuggg cgccagaggc      120

cccggcggca ccuuccaggg cagagaccug agaggcggcg cccacgccag cagcagcagc      180

cugaacccca ugccccccag ccagcugcag cugcccaccc ugccccuggu gaugguggcc      240

cccagcggcg ccagacuggg cccccugccc caccugcagg cccugcugca ggacagaccc      300

cacuucaugc accagcugag caccguggac gcccacgcca gaacccccgu gcugcaggug      360

cacccccugg agagccccgc caugaucagc cugacccccc ccaccaccgc caccggcgug      420

uucagccuga aggccagacc cggccugccc cccggcauca acguggccag ccuggagugg      480

gugagcagag agcccgcccu gcugugcacc uuccccaacc ccagcgcccc cagaaaggac      540

agcacccuga gcgccgugcc ccagagcagc uacccccugc uggccaacgg cgugugcaag      600

uggcccggcu gcgagaaggu guucgaggag cccgaggacu uccugaagca cugccaggcc      660

gaccaccugc uggacgagaa gggcagagcc cagugccugc ugcagagaga gauggugcag      720

agccuggagc agcagcuggu gcuggagaag gagaagcuga gcgccaugca ggcccaccug      780

gccggcaaga uggcccugac caaggccagc agcguggcca gcagcgacaa gggcagcugc      840

ugcaucgugg ccgccggcag ccagggcccc guggugcccg ccuggagcgg ccccagagag      900

gcccccgaca gccuguucgc cgugagaaga caccuguggg gcagccacgg caacagcacc      960

uuccccgagu uccugcacaa cauggacuac uucaaguucc acaacaugag accccccuuc     1020

accuacgcca cccugaucag augggccauc cuggaggccc ccgagaagca gagaacccug     1080

aacgagaucu accacugguu caccagaaug uucgccuucu ucagaaacca ccccgccacc     1140

uggaagaacg ccaucagaca caaccugagc cugcacaagu gcuucgugag aguggagagc     1200

gagaagggcg ccguguggac cguggacgag cuggaguuca gaaagaagag aagccagaga     1260

cccagcagau gcagcaaccc cacccccggc cccuga                               1296


<210>  1706
<211>  1296
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FOXP3__Homo_sapiens__AAG53607

<400>  1706
augcccaacc cuagaccggg caagcccagc gccccuuccc uggcucucgg gcccucuccu       60

ggagccagcc ccuccuggcg ggcggcuccu aaagccucug accugcuugg cgcccgcggg      120

ccgggaggca ccuuccaggg gagagaucug cggggaggcg cucacgccag cuccucuagc      180

cucaauccca ugccucccuc ccaacugcag cuuccuacac ugccccucgu gauggucgcu      240

ccgagcggcg cccgccuggg gccucugccc caucuccagg cgcugcuuca ggacagaccu      300

cacuuuaugc aucaacuguc uacgguugau gcccacgcuc ggacccccgu gcuccaggug      360

cauccccugg aauccccugc caugaucagc cuuacaccgc ccaccacagc uaccggaguc      420

uucucucuga aggcccgccc uggccugccc ccugggauua acguggcguc ccuggaaugg      480

guuagcagag agcccgcccu gcucugcaca uuuccgaauc cuucugcucc ccggaaagac      540

uccacccuga gcgccgugcc ucaguccucu uacccccuuc uggcuaacgg agucuguaag      600

uggccuggcu gcgaaaaagu guucgaggaa cccgaggauu uucucaagca cugucaggcc      660

gaccaccucc uugaugagaa ggggcgcgcc caaugccugc uccagagaga aaugguucag      720

agccuggagc agcaacuggu gcucgaaaaa gagaagcugu ccgcuaugca ggcgcaucuu      780

gccggaaaaa uggcucugac gaaggccagc ucugucgccu ccagcgacaa aggcucuugu      840

ugcaucgugg cugccggcag ccaggggccg guggucccug cgugguccgg accccgggag      900

gcucccgauu cucucuucgc cguucgcaga caccuguggg gcagccaugg aaauuccacc      960

uuuccugagu uccuucacaa cauggacuau uuuaaguucc acaauaugcg gccgcccuuu     1020

acauacgcca cccugauucg cugggcuauc cucgaagccc cugaaaagca aagaacacug     1080

aacgagauuu aucauugguu cacccggaug uuugcuuucu ucagaaauca ccccgccacg     1140

uggaaaaacg cgauccgcca uaaucugagc cuccacaagu guuuugugcg gguggaaucu     1200

gagaaagggg ccgucuggac aguggaugag cuggaguuca gaaagaaacg cucccagcgg     1260

ccuagcagau gcucuaaccc caccccuggc cccuga                               1296


<210>  1707
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FUT1__Homo_sapiens__P19526

<400>  1707

Met Trp Leu Arg Ser His Arg Gln Leu Cys Leu Ala Phe Leu Leu Val 
1               5                   10                  15      


Cys Val Leu Ser Val Ile Phe Phe Leu His Ile His Gln Asp Ser Phe 
            20                  25                  30          


Pro His Gly Leu Gly Leu Ser Ile Leu Cys Pro Asp Arg Arg Leu Val 
        35                  40                  45              


Thr Pro Pro Val Ala Ile Phe Cys Leu Pro Gly Thr Ala Met Gly Pro 
    50                  55                  60                  


Asn Ala Ser Ser Ser Cys Pro Gln His Pro Ala Ser Leu Ser Gly Thr 
65                  70                  75                  80  


Trp Thr Val Tyr Pro Asn Gly Arg Phe Gly Asn Gln Met Gly Gln Tyr 
                85                  90                  95      


Ala Thr Leu Leu Ala Leu Ala Gln Leu Asn Gly Arg Arg Ala Phe Ile 
            100                 105                 110         


Leu Pro Ala Met His Ala Ala Leu Ala Pro Val Phe Arg Ile Thr Leu 
        115                 120                 125             


Pro Val Leu Ala Pro Glu Val Asp Ser Arg Thr Pro Trp Arg Glu Leu 
    130                 135                 140                 


Gln Leu His Asp Trp Met Ser Glu Glu Tyr Ala Asp Leu Arg Asp Pro 
145                 150                 155                 160 


Phe Leu Lys Leu Ser Gly Phe Pro Cys Ser Trp Thr Phe Phe His His 
                165                 170                 175     


Leu Arg Glu Gln Ile Arg Arg Glu Phe Thr Leu His Asp His Leu Arg 
            180                 185                 190         


Glu Glu Ala Gln Ser Val Leu Gly Gln Leu Arg Leu Gly Arg Thr Gly 
        195                 200                 205             


Asp Arg Pro Arg Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr 
    210                 215                 220                 


Leu Gln Val Met Pro Gln Arg Trp Lys Gly Val Val Gly Asp Ser Ala 
225                 230                 235                 240 


Tyr Leu Arg Gln Ala Met Asp Trp Phe Arg Ala Arg His Glu Ala Pro 
                245                 250                 255     


Val Phe Val Val Thr Ser Asn Gly Met Glu Trp Cys Lys Glu Asn Ile 
            260                 265                 270         


Asp Thr Ser Gln Gly Asp Val Thr Phe Ala Gly Asp Gly Gln Glu Ala 
        275                 280                 285             


Thr Pro Trp Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile 
    290                 295                 300                 


Met Thr Ile Gly Thr Phe Gly Phe Trp Ala Ala Tyr Leu Ala Gly Gly 
305                 310                 315                 320 


Asp Thr Val Tyr Leu Ala Asn Phe Thr Leu Pro Asp Ser Glu Phe Leu 
                325                 330                 335     


Lys Ile Phe Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Val Gly Ile 
            340                 345                 350         


Asn Ala Asp Leu Ser Pro Leu Trp Thr Leu Ala Lys Pro 
        355                 360                 365 


<210>  1708
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FUT1__Homo_sapiens__AAA52639

<400>  1708
auguggcucc ggagccaucg ucagcucugc cuggccuucc ugcuagucug uguccucucu       60

guaaucuucu uccuccauau ccaucaagac agcuuuccac auggccuagg ccugucgauc      120

cuguguccag accgccgccu ggugacaccc ccaguggcca ucuucugccu gccggguacu      180

gcgaugggcc ccaacgccuc cucuuccugu ccccagcacc cugcuucccu cuccggcacc      240

uggacugucu accccaaugg ccgguuuggu aaucagaugg gacaguaugc cacgcugcug      300

gcucuggccc agcucaacgg ccgccgggcc uuuauccugc cugccaugca ugccgcccug      360

gccccgguau uccgcaucac ccugcccgug cuggccccag aaguggacag ccgcacgccg      420

uggcgggagc ugcagcuuca cgacuggaug ucggaggagu acgcggacuu gagagauccu      480

uuccugaagc ucucuggcuu ccccugcucu uggacuuucu uccaccaucu ccgggaacag      540

auccgcagag aguucacccu gcacgaccac cuucgggaag aggcgcagag ugugcugggu      600

cagcuccgcc ugggccgcac aggggaccgc ccgcgcaccu uugucggcgu ccacgugcgc      660

cguggggacu aucugcaggu uaugccucag cgcuggaagg gugugguggg cgacagcgcc      720

uaccuccggc aggccaugga cugguuccgg gcacggcacg aagcccccgu uuucgugguc      780

accagcaacg gcauggagug guguaaagaa aacaucgaca ccucccaggg cgaugugacg      840

uuugcuggcg auggacagga ggcuacaccg uggaaagacu uugcccugcu cacacagugc      900

aaccacacca uuaugaccau uggcaccuuc ggcuucuggg cugccuaccu ggcuggcgga      960

gacacugucu accuggccaa cuucacccug ccagacucug aguuccugaa gaucuuuaag     1020

ccggaggcgg ccuuccugcc cgagugggug ggcauuaaug cagacuuguc uccacucugg     1080

acauuggcua agccuuga                                                   1098


<210>  1709
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FUT1__Homo_sapiens__AAA52639

<400>  1709
auguggcugc gcagccaccg gcagcucugc cuggccuucc ugcucgugug cguccugucc       60

gugaucuucu uccugcacau ccaccaggac agcuuccccc acggccucgg gcuguccauc      120

cugugcccgg accgccggcu cgugaccccg cccgucgcca ucuucugccu gcccggcacc      180

gcgauggggc ccaacgccag cuccagcugc ccccagcacc ccgccucccu gagcggcacg      240

uggaccgugu accccaacgg gcgcuucggc aaccagaugg gccaguacgc cacccuccug      300

gcccuggcgc agcucaacgg gcggcgcgcc uucauccugc cggccaugca cgccgcgcug      360

gcccccgugu uccggaucac ccuccccguc cuggcccccg agguggacuc ccgcacgccg      420

uggcgggagc ugcagcucca cgacuggaug agcgaggagu acgccgaccu gcgcgacccc      480

uuccugaagc ucuccggcuu ccccugcagc uggaccuucu uccaccaccu ccgggagcag      540

auccgccggg aguucacccu gcacgaccac cuccgcgagg aggcccaguc cgugcugggg      600

cagcugcggc ugggccgcac cggggaccgg ccccgcacgu ucgucggcgu gcacgugcgg      660

cgcggcgacu accugcaggu caugccgcag cgguggaagg gggugguggg cgacagcgcg      720

uaccugcgcc aggccaugga cugguuccgc gcccggcacg aggcccccgu cuucguggug      780

accuccaacg ggauggagug gugcaaggag aacaucgaca ccagccaggg cgacgucacc      840

uucgccggcg acgggcagga ggcgacgccc uggaaggacu ucgcccuccu gacccagugc      900

aaccacacca ucaugaccau cggcacguuc ggguucuggg ccgccuaccu ggccggcggg      960

gacaccgugu accucgcgaa cuucacccug cccgacuccg aguuccugaa gaucuucaag     1020

ccggaggccg ccuuccuccc cgagugggug ggcaucaacg ccgaccugag cccccugugg     1080

acccucgcca agcccuga                                                   1098


<210>  1710
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FUT1__Homo_sapiens__AAA52639

<400>  1710
auguggcucc gcucccaccg ccagcucugc cucgccuucc uccucgucug cguccucucc       60

gucaucuucu uccuccacau ccaccaggac uccuuccccc acggccucgg ccucuccauc      120

cucugccccg accgccgccu cgucaccccc cccgucgcca ucuucugccu ccccggcacc      180

gccaugggcc ccaacgccuc cuccuccugc ccccagcacc ccgccucccu cuccggcacc      240

uggaccgucu accccaacgg ccgcuucggc aaccagaugg gccaguacgc cacccuccuc      300

gcccucgccc agcucaacgg ccgccgcgcc uucauccucc ccgccaugca cgccgcccuc      360

gcccccgucu uccgcaucac ccuccccguc cucgcccccg aggucgacuc ccgcaccccc      420

uggcgcgagc uccagcucca cgacuggaug uccgaggagu acgccgaccu ccgcgacccc      480

uuccucaagc ucuccggcuu ccccugcucc uggaccuucu uccaccaccu ccgcgagcag      540

auccgccgcg aguucacccu ccacgaccac cuccgcgagg aggcccaguc cguccucggc      600

cagcuccgcc ucggccgcac cggcgaccgc ccccgcaccu ucgucggcgu ccacguccgc      660

cgcggcgacu accuccaggu caugccccag cgcuggaagg gcgucgucgg cgacuccgcc      720

uaccuccgcc aggccaugga cugguuccgc gcccgccacg aggcccccgu cuucgucguc      780

accuccaacg gcauggagug gugcaaggag aacaucgaca ccucccaggg cgacgucacc      840

uucgccggcg acggccagga ggccaccccc uggaaggacu ucgcccuccu cacccagugc      900

aaccacacca ucaugaccau cggcaccuuc ggcuucuggg ccgccuaccu cgccggcggc      960

gacaccgucu accucgccaa cuucacccuc cccgacuccg aguuccucaa gaucuucaag     1020

cccgaggccg ccuuccuccc cgaguggguc ggcaucaacg ccgaccucuc cccccucugg     1080

acccucgcca agcccuga                                                   1098


<210>  1711
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FUT1__Homo_sapiens__AAA52639

<400>  1711
auguggcuga gaagccacag gcagcucugc cuugccuucc uguuggugug ugucuuaucc       60

guuaucuuuu uccugcauau ucaccaagac ucuuuucccc auggccuagg gcucucaaua      120

cugugcccug aucggcgccu ugugacccca ccgguagcua ucuucugucu gcccggaaca      180

gcaauggguc cuaacgccag uagcuccugc ccacagcacc ccgcgucuuu gucgggcacu      240

uggacggugu acccuaaugg gcgauuugga aaccagaugg gccaguaugc uacccuccug      300

gcccuggcac aacucaaugg ucguagagcc uucauuuuac cagcuaugca ugcagcccug      360

gcucccgucu uuaggaucac acuuccugug uuggccccag agguugacuc acggacuccg      420

uggcgcgaac ugcagcuaca cgauuggaug agcgaggaau acgcggaccu cagagauccc      480

uuccugaaac uuaguggguu uccuuguucc uggaccuucu uucaccaucu gagggagcag      540

auucggcgcg aguucacauu gcacgaccau cuccgagaag aggcacaguc ugugcuggga      600

caauuaagac ugggcaggac cggcgaucgg ccacguacuu uugucggggu gcacguacgc      660

agaggagacu aucuccaggu uaugccccag agguggaagg guguggucgg cgauagcgcc      720

uaccuucggc aggcuaugga cugguuccga gcccgccacg aagcaccugu guucgugguc      780

acauccaacg ggauggagug gugcaaggaa aauaucgaua ccucacaagg agacguuacg      840

uuugcuggcg auggucagga ggccacucca uggaaagacu ucgcgcuguu gacccagugu      900

aaccauacaa uaaugacuau cgggaccuuu ggauucuggg ccgcauaucu agcuggcggc      960

gacacagugu accuggccaa uuuuacccuc cccgauagug aguuccugaa gauuuuuaaa     1020

ccggaagcug ccuuccuucc ugagugggua gggaucaacg cagaccugag ccccuugugg     1080

acgcucgcca agccauga                                                   1098


<210>  1712
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FUT1__Homo_sapiens__AAA52639

<400>  1712
auguggcuga gaagccacag acagcugugc cuggccuucc ugcuggugug cgugcugagc       60

gugaucuucu uccugcacau ccaccaggac agcuuccccc acggccuggg ccugagcauc      120

cugugccccg acagaagacu ggugaccccc cccguggcca ucuucugccu gcccggcacc      180

gccaugggcc ccaacgccag cagcagcugc ccccagcacc ccgccagccu gagcggcacc      240

uggaccgugu accccaacgg cagauucggc aaccagaugg gccaguacgc cacccugcug      300

gcccuggccc agcugaacgg cagaagagcc uucauccugc ccgccaugca cgccgcccug      360

gcccccgugu ucagaaucac ccugcccgug cuggcccccg agguggacag cagaaccccc      420

uggagagagc ugcagcugca cgacuggaug agcgaggagu acgccgaccu gagagacccc      480

uuccugaagc ugagcggcuu ccccugcagc uggaccuucu uccaccaccu gagagagcag      540

aucagaagag aguucacccu gcacgaccac cugagagagg aggcccagag cgugcugggc      600

cagcugagac ugggcagaac cggcgacaga cccagaaccu ucgugggcgu gcacgugaga      660

agaggcgacu accugcaggu gaugccccag agauggaagg gcgugguggg cgacagcgcc      720

uaccugagac aggccaugga cugguucaga gccagacacg aggcccccgu guucguggug      780

accagcaacg gcauggagug gugcaaggag aacaucgaca ccagccaggg cgacgugacc      840

uucgccggcg acggccagga ggccaccccc uggaaggacu ucgcccugcu gacccagugc      900

aaccacacca ucaugaccau cggcaccuuc ggcuucuggg ccgccuaccu ggccggcggc      960

gacaccgugu accuggccaa cuucacccug cccgacagcg aguuccugaa gaucuucaag     1020

cccgaggccg ccuuccugcc cgagugggug ggcaucaacg ccgaccugag cccccugugg     1080

acccuggcca agcccuga                                                   1098


<210>  1713
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FUT1__Homo_sapiens__AAA52639

<400>  1713
auguggcuga gaagccaccg gcagcucugc cuggccuucc uucuggugug uguccucucc       60

guuaucuuuu uccugcauau ucaccaagac ucuuuucccc auggccuugg gcugagcauc      120

cucugcccug aucgcagacu ggugaccccg cccguggcua uuuucugucu gccuggaaca      180

gccaugggcc ccaacgcguc cucuagcugc ccucagcacc ccgcuucccu cucugggacg      240

uggaccgucu acccuaaugg acgguuuggc aaccagaugg ggcaguaugc cacacugcuu      300

gcccuggcuc aacucaaugg acgcagagcc uucauccugc cggcuaugca ugccgcgcuu      360

gcccccgugu uucggauuac ccugccuguu cucgcucccg agguggacag ccgcacaccu      420

uggagagaac ugcagcugca cgauuggaug uccgaggaau acgccgaccu ccgggauccc      480

uuccugaaac uuagcggcuu uccguguucu uggaccuucu uucaccaucu gcgcgagcag      540

aucagacggg aguucacacu ccacgaccau cugcgcgaag aggcucaguc cguccuuggc      600

caacugagac ucgggcggac cggagaucgc ccuagaacgu uugugggcgu ucacgugcgg      660

agaggggacu aucugcaggu caugccccag cgcuggaagg gagugguggg cgauagcgcc      720

uaccugcggc aggcgaugga cugguucaga gcccgccacg aagcuccugu cuucguugug      780

accucuaacg ggauggagug gugcaaggaa aauaucgaua caucccaagg agacgugacc      840

uuugccggcg auggccagga ggcuacaccc uggaaagacu ucgcccuccu gacccagugu      900

aaccauacga uuaugacaau cgggaccuuu ggauucuggg ccgcuuaucu ugcgggcggg      960

gacacagucu accuggccaa uuuuacccuc cccgauagcg aguuccugaa gauuuuuaaa     1020

ccugaagcug ccuuccuucc ggagugggug ggaaucaacg ccgaccuguc uccccucugg     1080

acccuggcua agccuuga                                                   1098


<210>  1714
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  G250__Homo_sapiens__Q16790

<400>  1714

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  1715
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  G250__Homo_sapiens__EAW58359

<400>  1715
auggcucccc ugugccccag ccccuggcuc ccucuguuga ucccggcccc ugcuccaggc       60

cucacugugc aacugcugcu gucacugcug cuucuggugc cuguccaucc ccagagguug      120

ccccggaugc aggaggauuc ccccuuggga ggaggcucuu cuggggaaga ugacccacug      180

ggcgaggagg aucugcccag ugaagaggau ucacccagag aggaggaucc acccggagag      240

gaggaucuac cuggagagga ggaucuaccu ggagaggagg aucuaccuga aguuaagccu      300

aaaucagaag aagagggcuc ccugaaguua gaggaucuac cuacuguuga ggcuccugga      360

gauccucaag aaccccagaa uaaugcccac agggacaaag aaggggauga ccagagucau      420

uggcgcuaug gaggcgaccc gcccuggccc cggguguccc cagccugcgc gggccgcuuc      480

caguccccgg uggauauccg cccccagcuc gccgccuucu gcccggcccu gcgcccccug      540

gaacuccugg gcuuccagcu cccgccgcuc ccagaacugc gccugcgcaa caauggccac      600

agugugcaac ugacccugcc uccugggcua gagauggcuc ugggucccgg gcgggaguac      660

cgggcucugc agcugcaucu gcacuggggg gcugcagguc guccgggcuc ggagcacacu      720

guggaaggcc accguuuccc ugccgagauc cacgugguuc accucagcac cgccuuugcc      780

agaguugacg aggccuuggg gcgcccggga ggccuggccg uguuggccgc cuuucuggag      840

gagggcccgg aagaaaacag ugccuaugag caguugcugu cucgcuugga agaaaucgcu      900

gaggaaggcu cagagacuca ggucccagga cuggacauau cugcacuccu gcccucugac      960

uucagccgcu acuuccaaua ugaggggucu cugacuacac cgcccugugc ccaggguguc     1020

aucuggacug uguuuaacca gacagugaug cugagugcua agcagcucca cacccucucu     1080

gacacccugu ggggaccugg ugacucucgg cuacagcuga acuuccgagc gacgcagccu     1140

uugaaugggc gagugauuga ggccuccuuc ccugcuggag uggacagcag uccucgggcu     1200

gcugagccag uccagcugaa uuccugccug gcugcuggug acauccuagc ccugguuuuu     1260

ggccuccuuu uugcugucac cagcgucgcg uuccuugugc agaugagaag gcagcacaga     1320

aggggaacca aagggggugu gagcuaccgc ccagcagagg uagccgagac uggagccuag     1380


<210>  1716
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       G250__Homo_sapiens__EAW58359

<400>  1716
auggcgcccc ugugcccgag ccccuggcuc ccccugcuga uccccgcccc ggcccccggc       60

cucaccgugc agcugcugcu cucccugcug cuccuggucc ccgugcaccc ccagcgccug      120

ccgcggaugc aggaggacag cccccucggg ggcgggucca gcggcgagga cgacccccug      180

ggggaggagg accugcccuc cgaggaggac agcccgcgcg aggaggaccc gcccggcgag      240

gaggaccucc ccggcgagga ggaccugccc ggggaggagg accugcccga ggugaagccc      300

aaguccgagg aggagggcag ccucaagcug gaggaccugc ccaccgucga ggccccgggg      360

gacccccagg agccccagaa caacgcccac cgggacaagg agggcgacga ccagucccac      420

uggcgcuacg ggggcgaccc gcccuggccc cgggugagcc ccgccugcgc cggccgcuuc      480

cagucccccg uggacauccg gccgcagcuc gcggccuucu gccccgcccu gcgcccccug      540

gagcuccugg gguuccagcu gccgccccuc cccgagcugc ggcugcgcaa caacggccac      600

agcguccagc ucacgcugcc cccggggcug gagauggccc ucggccccgg ccgggaguac      660

cgcgcgcugc agcugcaccu ccacuggggc gccgccgggc ggcccggguc cgagcacacc      720

guggagggcc accgcuuccc cgccgagauc cacguggucc accugagcac cgccuucgcg      780

cggguggacg aggcccuggg gcgcccgggc ggccucgccg ugcuggccgc cuuccuggag      840

gaggggcccg aggagaacuc cgcguacgag cagcuccuga gccggcugga ggagaucgcc      900

gaggagggcu ccgagaccca gguccccggg cucgacauca gcgcccugcu gcccuccgac      960

uucagccgcu acuuccagua cgagggcagc cucacgaccc cgcccugcgc ccagggggug     1020

aucuggaccg uguucaacca gaccgucaug cuguccgcca agcagcugca cacgcugagc     1080

gacacccucu ggggccccgg cgacucccgg cugcagcuga acuuccgcgc gacccagccc     1140

cucaacgggc gggugaucga ggccagcuuc ccggccggcg uggacuccag cccccgcgcc     1200

gccgagcccg uccagcugaa cuccugccug gcggccgggg acauccucgc ccugguguuc     1260

ggccuccugu ucgccgugac cagcgucgcg uuccuggugc agaugcgccg gcagcaccgc     1320

cgggggacga agggcggcgu guccuaccgc cccgccgagg ucgccgagac cggggccuga     1380


<210>  1717
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       G250__Homo_sapiens__EAW58359

<400>  1717
auggcccccc ucugccccuc ccccuggcuc ccccuccuca uccccgcccc cgcccccggc       60

cucaccgucc agcuccuccu cucccuccuc cuccucgucc ccguccaccc ccagcgccuc      120

ccccgcaugc aggaggacuc cccccucggc ggcggcuccu ccggcgagga cgacccccuc      180

ggcgaggagg accuccccuc cgaggaggac uccccccgcg aggaggaccc ccccggcgag      240

gaggaccucc ccggcgagga ggaccucccc ggcgaggagg accuccccga ggucaagccc      300

aaguccgagg aggagggcuc ccucaagcuc gaggaccucc ccaccgucga ggcccccggc      360

gacccccagg agccccagaa caacgcccac cgcgacaagg agggcgacga ccagucccac      420

uggcgcuacg gcggcgaccc ccccuggccc cgcgucuccc ccgccugcgc cggccgcuuc      480

cagucccccg ucgacauccg cccccagcuc gccgccuucu gccccgcccu ccgcccccuc      540

gagcuccucg gcuuccagcu ccccccccuc cccgagcucc gccuccgcaa caacggccac      600

uccguccagc ucacccuccc ccccggccuc gagauggccc ucggccccgg ccgcgaguac      660

cgcgcccucc agcuccaccu ccacuggggc gccgccggcc gccccggcuc cgagcacacc      720

gucgagggcc accgcuuccc cgccgagauc cacgucgucc accucuccac cgccuucgcc      780

cgcgucgacg aggcccucgg ccgccccggc ggccucgccg uccucgccgc cuuccucgag      840

gagggccccg aggagaacuc cgccuacgag cagcuccucu cccgccucga ggagaucgcc      900

gaggagggcu ccgagaccca gguccccggc cucgacaucu ccgcccuccu ccccuccgac      960

uucucccgcu acuuccagua cgagggcucc cucaccaccc cccccugcgc ccagggcguc     1020

aucuggaccg ucuucaacca gaccgucaug cucuccgcca agcagcucca cacccucucc     1080

gacacccucu ggggccccgg cgacucccgc cuccagcuca acuuccgcgc cacccagccc     1140

cucaacggcc gcgucaucga ggccuccuuc cccgccggcg ucgacuccuc cccccgcgcc     1200

gccgagcccg uccagcucaa cuccugccuc gccgccggcg acauccucgc ccucgucuuc     1260

ggccuccucu ucgccgucac cuccgucgcc uuccucgucc agaugcgccg ccagcaccgc     1320

cgcggcacca agggcggcgu cuccuaccgc cccgccgagg ucgccgagac cggcgccuga     1380


<210>  1718
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       G250__Homo_sapiens__EAW58359

<400>  1718
auggcucccc ugugcccuag cccauggcuc ccgcuucuga uccccgcucc ugcaccaggc       60

uugaccgugc aguuacugcu aucccuccug cuucuggucc ccguucaccc ucaaagauug      120

ccaaggaugc aggaggacuc uccccucggg ggagguucaa guggcgaaga ugacccucug      180

ggggaggaag aucugccaag cgaggaagac uccccgcggg aggaggaucc cccuggagaa      240

gaggaccucc caggcgaaga ggauuuaccc ggugaggaag accugccuga ggugaagcca      300

aaaucugaag aggaaggguc gcuuaaguug gaggaucugc ccacaguaga ggccccggga      360

gacccucagg aaccccagaa caaugcgcau cgcgauaaag agggcgacga ucaaucacac      420

uggcgauacg gcggggaccc accuuggccc cgugugagcc cagcuugugc cggaagauuc      480

cagagucccg ucgacauuag gccucagcua gcagccuuuu gcccagcucu ccggccgcug      540

gaacuucugg guuuccaguu gcccccucuc ccagagcugc gcuuaagaaa caauggccau      600

uccgugcaac ugacuuugcc cccugggcuu gaaauggcac ugggaccagg cagggaguau      660

cgggccuugc agcuacaucu gcacuggggu gcugccgggc gccccggauc ugagcacacg      720

guugaaggcc accgauuucc ggcggagaua cauguggucc accucagcac cgcauucgcc      780

agaguggaug aagcucuggg caggccuggg ggacuugccg uacuggcagc uuuucucgag      840

gaagguccag aggagaacuc cgccuacgaa cagcuccugu cacgguuaga ggaaaucgcg      900

gaggagggca gugaaacaca gguucccggg cuggacauua gcgcccuacu cccuucugau      960

uucucccguu auuuucaaua cgagggauca cugacuacac ccccaugugc acagggcgug     1020

aucuggaccg ucuucaauca gaccgugaug cuuagcgcua agcaauugca uacucugagu     1080

gacacacucu gggguccugg ggauucucgc cugcagcuua acuuuagagc cacccagccc     1140

cugaauggca gggugauuga agccuccuuc ccagccggag ucgacagcuc gccgcgggca     1200

gccgagccug uucaguugaa cucuugccuc gcugcgggcg auauccuggc auuaguguuu     1260

gggcugcuau ucgccguaac guccguggcu uuucucgucc aaaugcgacg ccagcacaga     1320

aggggaacua aagguggcgu gucauaucgg cccgccgaag uugcagagac cggggccuga     1380


<210>  1719
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       G250__Homo_sapiens__EAW58359

<400>  1719
auggcccccc ugugccccag ccccuggcug ccccugcuga uccccgcccc cgcccccggc       60

cugaccgugc agcugcugcu gagccugcug cugcuggugc ccgugcaccc ccagagacug      120

cccagaaugc aggaggacag cccccugggc ggcggcagca gcggcgagga cgacccccug      180

ggcgaggagg accugcccag cgaggaggac agccccagag aggaggaccc ccccggcgag      240

gaggaccugc ccggcgagga ggaccugccc ggcgaggagg accugcccga ggugaagccc      300

aagagcgagg aggagggcag ccugaagcug gaggaccugc ccaccgugga ggcccccggc      360

gacccccagg agccccagaa caacgcccac agagacaagg agggcgacga ccagagccac      420

uggagauacg gcggcgaccc ccccuggccc agagugagcc ccgccugcgc cggcagauuc      480

cagagccccg uggacaucag accccagcug gccgccuucu gccccgcccu gagaccccug      540

gagcugcugg gcuuccagcu gcccccccug cccgagcuga gacugagaaa caacggccac      600

agcgugcagc ugacccugcc ccccggccug gagauggccc ugggccccgg cagagaguac      660

agagcccugc agcugcaccu gcacuggggc gccgccggca gacccggcag cgagcacacc      720

guggagggcc acagauuccc cgccgagauc cacguggugc accugagcac cgccuucgcc      780

agaguggacg aggcccuggg cagacccggc ggccuggccg ugcuggccgc cuuccuggag      840

gagggccccg aggagaacag cgccuacgag cagcugcuga gcagacugga ggagaucgcc      900

gaggagggca gcgagaccca ggugcccggc cuggacauca gcgcccugcu gcccagcgac      960

uucagcagau acuuccagua cgagggcagc cugaccaccc cccccugcgc ccagggcgug     1020

aucuggaccg uguucaacca gaccgugaug cugagcgcca agcagcugca cacccugagc     1080

gacacccugu ggggccccgg cgacagcaga cugcagcuga acuucagagc cacccagccc     1140

cugaacggca gagugaucga ggccagcuuc cccgccggcg uggacagcag ccccagagcc     1200

gccgagcccg ugcagcugaa cagcugccug gccgccggcg acauccuggc ccugguguuc     1260

ggccugcugu ucgccgugac cagcguggcc uuccuggugc agaugagaag acagcacaga     1320

agaggcacca agggcggcgu gagcuacaga cccgccgagg uggccgagac cggcgccuga     1380


<210>  1720
<211>  1380
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       G250__Homo_sapiens__EAW58359

<400>  1720
auggcucccc ugugcccuag cccguggcuc ccccugcuua ucccugcccc cgccccuggc       60

cugaccgugc agcuccugcu uucccugcuc cugcuggucc ccguucaccc ucaaagacuc      120

ccgcggaugc aggaggacuc uccccucggg ggaggcagcu ccggggaaga ugacccucuu      180

ggagaggaag aucugcccuc ugaggaagac agcccucgcg aggaggaucc cccgggcgaa      240

gaggaccucc cuggggaaga ggaucugccc ggagaggaag accuuccuga ggugaagccc      300

aaauccgaag aggaaggcuc ucugaagcuc gaggaucugc ccacagugga ggcgccuggc      360

gacccgcagg aaccccagaa caaugcucau agagauaaag agggggacga ucaaagccac      420

uggcgguacg gaggcgaccc ucccuggccu cgcgucuccc ccgccugugc cgggagauuc      480

cagagcccgg uggacauucg gccucagcug gcugccuuuu gccccgcucu ccgcccucug      540

gaacuucugg gauuccagcu gcccccucug cccgagcuua gacugcggaa caauggccau      600

ucuguucaac ucacgcugcc gccugggcug gaaauggccc ucggacccgg ccgcgaguau      660

agagcgcugc agcuucaucu gcacuggggc gccgcugggc ggcccggauc cgagcacacc      720

guggaaggcc accgcuuucc ugccgagauc caugucgugc accucagcac agcuuucgcc      780

agaguugaug aagcgcuggg gcggccggga ggccuugccg ugcuggcugc cuuucucgag      840

gaagggcccg aggagaacuc ugcuuacgaa cagcugcugu cccgccucga ggaaauugcc      900

gaggagggaa gcgaaaccca ggucccuggc cuggacaucu cugcccuucu gcccuccgau      960

uucagcagau auuuucaaua cgagggcucc cucacaaccc cucccugugc ucagggggug     1020

auuuggacag uguucaauca gaccgucaug cugucugcga agcaacugca uacgcuuagc     1080

gacacccucu ggggaccugg cgauucccgg cugcagcuga acuuuagagc cacacagccc     1140

cucaaugggc gcguuaucga agcuagcuuc ccggccggag uggacucuuc cccucgggcc     1200

gcugagcccg ugcagcugaa cagcugccuu gccgcgggcg auauccuggc ucucgucuuu     1260

gggcugcugu ucgccgugac cucuguugcc uuucuugugc aaaugagacg ccagcaccgg     1320

agaggcacaa aaggaggcgu cagcuaucgc ccugcugaag uggccgagac cggggcuuga     1380


<210>  1721
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-1__Homo_sapiens__AAA82744

<400>  1721

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly His 
65                  70                  75                  80  


Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Glu Met Arg 
            100                 105                 110         


Ser His Tyr Val Ala Gln Thr Gly Ile Leu Trp Leu Leu Met Asn Asn 
        115                 120                 125             


Cys Phe Leu Asn Leu Ser Pro Arg Lys Pro 
    130                 135             


<210>  1722
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-1__Homo_sapiens__U19142.1

<400>  1722
augaguuggc gaggaagauc gaccuaucgg ccuagaccaa gacgcuacgu agagccuccu       60

gaaaugauug ggccuaugcg gcccgagcag uucagugaug aaguggaacc agcaacaccu      120

gaagaagggg aaccagcaac ucaacgucag gauccugcag cugcucagga gggagaggau      180

gagggagcau cugcagguca agggccgaag ccugaagcug auagccagga acagggucac      240

ccacagacug ggugugagug ugaagauggu ccugaugggc aggagaugga cccgccaaau      300

ccagaggagg ugaaaacgcc ugaagaagag augaggucuc acuauguugc ccagacuggg      360

auucucuggc uuuuaaugaa caauugcuuc uuaaaucuuu ccccacggaa accuuga         417


<210>  1723
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-1__Homo_sapiens__U19142.1

<400>  1723
augagcuggc gcggccgguc caccuaccgc ccccggccgc gccgguacgu ggagccgccc       60

gagaugaucg ggcccaugcg ccccgagcag uucagcgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac gcagcggcag gacccggcgg ccgcccagga gggggaggac      180

gagggcgccu ccgccgggca gggccccaag cccgaggcgg acagccagga gcagggccac      240

ccccagaccg ggugcgagug cgaggacggc ccggacgggc aggagaugga cccgcccaac      300

cccgaggagg ugaagacccc cgaggaggag augcgcuccc acuacguggc ccagaccggc      360

auccuguggc uccugaugaa caacugcuuc cugaaccuca gcccccggaa gcccuga         417


<210>  1724
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-1__Homo_sapiens__U19142.1

<400>  1724
auguccuggc gcggccgcuc caccuaccgc ccccgccccc gccgcuacgu cgagcccccc       60

gagaugaucg gccccaugcg ccccgagcag uucuccgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac ccagcgccag gaccccgccg ccgcccagga gggcgaggac      180

gagggcgccu ccgccggcca gggccccaag cccgaggccg acucccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ucaagacccc cgaggaggag augcgcuccc acuacgucgc ccagaccggc      360

auccucuggc uccucaugaa caacugcuuc cucaaccucu ccccccgcaa gcccuga         417


<210>  1725
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-1__Homo_sapiens__U19142.1

<400>  1725
augagcugga gaggcagguc caccuaccgg ccccgcccuc gacguuaugu ggagccaccg       60

gaaaugaucg ggcccaugag accugagcag uucucugacg aagucgagcc agccacaccc      120

gaagagggag agccugcuac ucaaaggcag gacccagcag ccgcgcagga aggugaggac      180

gaaggcgcuu cagccgggca gggacccaag ccugaggcag auagucaaga gcagggccac      240

ccacagacgg guugcgaaug ugaggacggg ccggauggac aggaaaugga ucccccuaac      300

ccagaggaag uuaaaacccc cgaggaggaa augcggagcc auuacguggc ccaaacaggc      360

auucuguggc uccuuaugaa uaacugcuuu cugaauuugu ccccucgcaa gccauga         417


<210>  1726
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-1__Homo_sapiens__U19142.1

<400>  1726
augagcugga gaggcagaag caccuacaga cccagaccca gaagauacgu ggagcccccc       60

gagaugaucg gccccaugag acccgagcag uucagcgacg agguggagcc cgccaccccc      120

gaggagggcg agcccgccac ccagagacag gaccccgccg ccgcccagga gggcgaggac      180

gagggcgcca gcgccggcca gggccccaag cccgaggccg acagccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ugaagacccc cgaggaggag augagaagcc acuacguggc ccagaccggc      360

auccuguggc ugcugaugaa caacugcuuc cugaaccuga gccccagaaa gcccuga         417


<210>  1727
<211>  417
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-1__Homo_sapiens__U19142.1

<400>  1727
augagcugga gaggccgguc caccuaccgc cccagaccuc ggcgcuaugu ggagccgccc       60

gaaaugaucg ggccuaugag acccgagcag uucucugacg aagucgagcc ugccacaccc      120

gaagagggag agccugcuac gcaacggcag gacccggccg cggcucagga aggcgaggac      180

gaaggggcca gcgccggaca gggccccaag ccugaggcug auucccaaga gcaggggcac      240

ccccagaccg gaugcgaaug ugaggacggc ccugauggcc aggaaaugga ucccccgaac      300

ccugaggaag uuaaaacacc cgaggaggaa augcgcucuc auuacguggc ccaaaccggg      360

auucuguggc uccugaugaa uaacugcuuu cuuaaucuga gcccuagaaa gcccuga         417


<210>  1728
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-2__Homo_sapiens__Q6NT46

<400>  1728

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Gln Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala His Ser Gln Glu Gln Gly His 
65                  70                  75                  80  


Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu Lys 
            100                 105                 110         


Gln Ser Gln Cys 
        115     


<210>  1729
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-2__Homo_sapiens__AAH69397

<400>  1729
augaguuggc gaggaagauc gaccuaucgg ccuagaccaa gacgcuacgu agagccuccu       60

gaaaugauug ggccuaugcg gcccgagcag uucagugaug aaguggaacc agcaacaccu      120

gaagaagggg aaccagcaac ucaacgucag gauccugcag cugcucagga gggacaggau      180

gagggagcau cugcagguca agggccgaag ccugaagcuc auagccagga acagggucac      240

ccacagacug ggugugagug ugaagauggu ccugaugggc aggagaugga cccgccaaau      300

ccagaggagg ugaaaacgcc ugaagaaggu gaaaagcaau cacaguguua a               351


<210>  1730
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-2__Homo_sapiens__AAH69397

<400>  1730
augagcuggc gcggccgguc caccuaccgc ccccggccgc gccgguacgu ggagccgccc       60

gagaugaucg ggcccaugcg ccccgagcag uucagcgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac gcagcggcag gacccggcgg ccgcccagga ggggcaggac      180

gagggcgccu ccgccgggca gggccccaag cccgaggcgc acagccagga gcagggccac      240

ccccagaccg ggugcgagug cgaggacggc ccggacgggc aggagaugga cccgcccaac      300

cccgaggagg ugaagacccc cgaggagggc gagaagcagu cccagugcug a               351


<210>  1731
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-2__Homo_sapiens__AAH69397

<400>  1731
auguccuggc gcggccgcuc caccuaccgc ccccgccccc gccgcuacgu cgagcccccc       60

gagaugaucg gccccaugcg ccccgagcag uucuccgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac ccagcgccag gaccccgccg ccgcccagga gggccaggac      180

gagggcgccu ccgccggcca gggccccaag cccgaggccc acucccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ucaagacccc cgaggagggc gagaagcagu cccagugcug a               351


<210>  1732
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-2__Homo_sapiens__AAH69397

<400>  1732
augagcugga gaggcagguc caccuaccgg ccccgcccuc gacguuaugu ggagccaccg       60

gaaaugaucg ggcccaugag accugagcag uucucugacg aagucgagcc agccacaccc      120

gaagagggag agccugcuac ucaaaggcag gauccagcag ccgcgcagga aggucaggac      180

gagggcgcuu cagccgggca aggacccaag ccugaagcac acagucagga gcagggccau      240

ccacagacgg guugcgagug ugaagauggg ccggacggac aagagaugga ucccccuaac      300

ccagaagagg uuaaaacccc cgaagagggc gagaagcaga gccagugcug a               351


<210>  1733
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-2__Homo_sapiens__AAH69397

<400>  1733
augagcugga gaggcagaag caccuacaga cccagaccca gaagauacgu ggagcccccc       60

gagaugaucg gccccaugag acccgagcag uucagcgacg agguggagcc cgccaccccc      120

gaggagggcg agcccgccac ccagagacag gaccccgccg ccgcccagga gggccaggac      180

gagggcgcca gcgccggcca gggccccaag cccgaggccc acagccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ugaagacccc cgaggagggc gagaagcaga gccagugcug a               351


<210>  1734
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-2__Homo_sapiens__AAH69397

<400>  1734
augagcugga gaggccgguc caccuaccgc cccagaccuc ggcgcuaugu ggagccgccc       60

gaaaugaucg ggccuaugag acccgagcag uucucugacg aagucgagcc ugccacaccc      120

gaagagggag agccugcuac gcaacggcag gauccggccg cggcucagga aggccaggac      180

gagggggcca gcgccggaca aggccccaag ccugaagcuc acucccagga gcaggggcau      240

ccccagaccg gaugcgagug ugaagauggc ccugacggcc aagagaugga ucccccgaac      300

ccugaagagg uuaaaacacc cgaagagggg gagaagcagu cucagugcug a               351


<210>  1735
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-3__Homo_sapiens__Q13067

<400>  1735

Met Asn Leu Ser Arg Gly Lys Ser Thr Tyr Tyr Trp Pro Arg Pro Arg 
1               5                   10                  15      


Arg Tyr Val Gln Pro Pro Glu Val Ile Gly Pro Met Arg Pro Glu Gln 
            20                  25                  30          


Phe Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala 
        35                  40                  45              


Thr Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly 
    50                  55                  60                  


Ala Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln 
65                  70                  75                  80  


Gly His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln 
                85                  90                  95      


Glu Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly 
            100                 105                 110         


Glu Lys Gln Ser Gln Cys 
        115             


<210>  1736
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-3__Homo_sapiens__AAA82746

<400>  1736
augaaucuca guagaggaaa aucgaccuau uauuggccua gaccaaggcg cuauguacag       60

ccuccugaag ugauugggcc uaugcggccc gagcaguuca gugaugaagu ggaaccagca      120

acaccugaag aaggggaacc agcaacucaa cgucaggauc cugcagcugc ucaggaggga      180

gaggaugagg gagcaucugc aggucaaggg ccgaagccug aagcugauag ccaggaacag      240

ggucacccac agacugggug ugagugugaa gaugguccug augggcagga gauggacccg      300

ccaaauccag aggaggugaa aacgccugaa gaaggugaaa agcaaucaca guguuaa         357


<210>  1737
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-3__Homo_sapiens__AAA82746

<400>  1737
augaaccuga gccgcggcaa guccaccuac uacuggcccc ggccgcgccg guacgugcag       60

ccgcccgagg ucaucgggcc caugcgcccc gagcaguuca gcgacgaggu ggagcccgcc      120

acccccgagg agggcgagcc cgccacgcag cggcaggacc cggcggccgc ccaggagggg      180

gaggacgagg gcgccuccgc cgggcagggc cccaagcccg aggcggacag ccaggagcag      240

ggccaccccc agaccgggug cgagugcgag gacggcccgg acgggcagga gauggacccg      300

cccaaccccg aggaggugaa gacccccgag gagggcgaga agcaguccca gugcuga         357


<210>  1738
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-3__Homo_sapiens__AAA82746

<400>  1738
augaaccucu cccgcggcaa guccaccuac uacuggcccc gcccccgccg cuacguccag       60

ccccccgagg ucaucggccc caugcgcccc gagcaguucu ccgacgaggu cgagcccgcc      120

acccccgagg agggcgagcc cgccacccag cgccaggacc ccgccgccgc ccaggagggc      180

gaggacgagg gcgccuccgc cggccagggc cccaagcccg aggccgacuc ccaggagcag      240

ggccaccccc agaccggcug cgagugcgag gacggccccg acggccagga gauggacccc      300

cccaaccccg aggaggucaa gacccccgag gagggcgaga agcaguccca gugcuga         357


<210>  1739
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-3__Homo_sapiens__AAA82746

<400>  1739
augaaccuga gcagaggcaa guccaccuac uauuggccca ggccucggcg cuacgugcag       60

ccaccggagg ucaucgggcc caugcgaccu gaacaauucu cugacgaggu ugaaccagcc      120

acacccgagg aaggagagcc ugcuacucag cgucaggacc cagcagccgc gcaggagggu      180

gaagacgagg gcgcuucagc cgggcaagga cccaaaccug aagcagauag ucaggagcag      240

ggccacccac agacggguug cgagugugaa gacgggccgg auggacaaga gauggauccc      300

ccuaauccag aagaggugaa gacccccgaa gagggcgaga aacagagcca gugcuga         357


<210>  1740
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-3__Homo_sapiens__AAA82746

<400>  1740
augaaccuga gcagaggcaa gagcaccuac uacuggccca gacccagaag auacgugcag       60

ccccccgagg ugaucggccc caugagaccc gagcaguuca gcgacgaggu ggagcccgcc      120

acccccgagg agggcgagcc cgccacccag agacaggacc ccgccgccgc ccaggagggc      180

gaggacgagg gcgccagcgc cggccagggc cccaagcccg aggccgacag ccaggagcag      240

ggccaccccc agaccggcug cgagugcgag gacggccccg acggccagga gauggacccc      300

cccaaccccg aggaggugaa gacccccgag gagggcgaga agcagagcca gugcuga         357


<210>  1741
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-3__Homo_sapiens__AAA82746

<400>  1741
augaaccuga gcagaggcaa guccaccuac uauuggcccc ggccucgcag auacgugcag       60

ccgcccgagg ucaucgggcc uaugcggccc gaacaauucu cugacgaggu ugaaccugcc      120

acacccgagg aaggagagcc ugcuacgcag cgccaggacc cggccgcggc ucaggagggc      180

gaagacgagg gggccagcgc cggacaaggc cccaaaccug aagcugauuc ccaggagcag      240

gggcaccccc agaccggaug cgagugugaa gacggcccug auggccaaga gauggauccc      300

ccgaauccug aagaggugaa gacacccgaa gagggggaga aacagucuca gugcuga         357


<210>  1742
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-4__Homo_sapiens__Q13068

<400>  1742

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Gly Gln Ser Gln Cys 
        115         


<210>  1743
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-4__Homo_sapiens__AAH69470

<400>  1743
augaguuggc gaggaagauc gaccuauuau uggccuagac caaggcgcua uguacagccu       60

ccugaaauga uugggccuau gcggcccgag caguucagug augaagugga accagcaaca      120

ccugaagaag gggaaccagc aacucaacgu caggauccug cagcugcuca ggagggagag      180

gaugagggag caucugcagg ucaagggccg aagccugaag cugauagcca ggaacagggu      240

cacccacaga cuggguguga gugugaagau gguccugaug ggcaggagau ggacccgcca      300

aauccagagg aggugaaaac gccugaagaa ggugaagggc aaucacagug uuaa            354


<210>  1744
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-4__Homo_sapiens__AAH69470

<400>  1744
augagcuggc gcggccgguc caccuacuac uggccccgcc cgcggcgcua cgugcagccg       60

cccgagauga ucgggcccau gcggcccgag caguucagcg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacgcagcgc caggacccgg cggccgccca ggagggggag      180

gacgagggcg ccuccgccgg gcagggcccc aagcccgagg cggacagcca ggagcagggc      240

cacccccaga ccgggugcga gugcgaggac ggcccggacg ggcaggagau ggacccgccc      300

aaccccgagg aggugaagac ccccgaggag ggcgaggggc agucccagug cuga            354


<210>  1745
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-4__Homo_sapiens__AAH69470

<400>  1745
auguccuggc gcggccgcuc caccuacuac uggccccgcc cccgccgcua cguccagccc       60

cccgagauga ucggccccau gcgccccgag caguucuccg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagcgc caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccuccgccgg ccagggcccc aagcccgagg ccgacuccca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggucaagac ccccgaggag ggcgagggcc agucccagug cuga            354


<210>  1746
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-4__Homo_sapiens__AAH69470

<400>  1746
augagcugga gaggcagguc caccuacuau uggccccggc cucgccgaua cgugcagcca       60

ccggagauga ucgggcccau gcguccugaa caauucucug acgaggucga accagccaca      120

cccgaggaag gagagccugc uacucagaga caggacccag cagccgcgca ggagggugaa      180

gacgagggcg cuucagccgg gcaaggaccc aagccugaag cagauaguca ggagcagggc      240

cacccacaga cggguugcga gugugaagac gggccggaug gacaagagau ggaucccccu      300

aacccagaag agguuaaaac ccccgaagag ggcgagggcc agagccagug cuga            354


<210>  1747
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-4__Homo_sapiens__AAH69470

<400>  1747
augagcugga gaggcagaag caccuacuac uggcccagac ccagaagaua cgugcagccc       60

cccgagauga ucggccccau gagacccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagaga caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccagcgccgg ccagggcccc aagcccgagg ccgacagcca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagggcc agagccagug cuga            354


<210>  1748
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-4__Homo_sapiens__AAH69470

<400>  1748
augagcugga gaggccgguc caccuacuau uggccccgcc cuagacggua cgugcagccg       60

cccgagauga ucgggccuau gcgccccgaa caauucucug acgaggucga accugccaca      120

cccgaggaag gagagccugc uacgcagaga caggacccgg ccgcggcuca ggagggcgaa      180

gacgaggggg ccagcgccgg acaaggcccc aagccugaag cugauuccca ggagcagggg      240

cacccccaga ccggaugcga gugugaagac ggcccugaug gccaagagau ggaucccccg      300

aacccugaag agguuaaaac acccgaagag ggggagggac agucucagug cuga            354


<210>  1749
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-5__Homo_sapiens__Q13069

<400>  1749

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Val Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Lys Gln Ser Gln Cys 
        115         


<210>  1750
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-5__Homo_sapiens__AAA82748

<400>  1750
augaguuggc gaggaagauc gaccuauuau uggccuagac caaggcgcua uguacagccu       60

ccugaaguga uugggccuau gcggcccgag caguucagug augaagugga accagcaaca      120

ccugaagaag gggaaccagc aacucaacgu caggauccug cagcugcuca ggagggagag      180

gaugagggag caucugcagg ucaagggccg aagccugaag cugauagcca ggaacagggu      240

cacccacaga cuggguguga gugugaagau gguccugaug ggcaggagau ggacccgcca      300

aauccagagg aggugaaaac gccugaagaa ggugaaaagc aaucacagug uuaa            354


<210>  1751
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-5__Homo_sapiens__AAA82748

<400>  1751
augagcuggc gcggccgguc caccuacuac uggccccgcc cgcggcgcua cgugcagccg       60

cccgagguca ucgggcccau gcggcccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacgcagcgc caggacccgg cggccgccca ggagggggag      180

gacgagggcg ccuccgccgg gcagggcccc aagcccgagg cggacagcca ggagcagggc      240

cacccccaga ccgggugcga gugcgaggac ggcccggacg ggcaggagau ggacccgccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1752
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-5__Homo_sapiens__AAA82748

<400>  1752
auguccuggc gcggccgcuc caccuacuac uggccccgcc cccgccgcua cguccagccc       60

cccgagguca ucggccccau gcgccccgag caguucuccg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagcgc caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccuccgccgg ccagggcccc aagcccgagg ccgacuccca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggucaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1753
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-5__Homo_sapiens__AAA82748

<400>  1753
augagcugga gaggcagguc caccuacuau uggccccggc cucgccgaua cgugcagcca       60

ccggagguca ucgggcccau gcguccugaa caauucucug acgagguuga accagccaca      120

cccgaggaag gagagccugc uacucagaga caggacccag cagccgcgca ggagggugaa      180

gacgagggcg cuucagccgg gcaaggaccc aagccugaag cagauaguca ggagcagggc      240

cacccacaga cggguugcga gugugaagac gggccggaug gacaagagau ggaucccccu      300

aacccagaag aggugaaaac ccccgaagag ggcgagaagc agagccagug cuga            354


<210>  1754
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-5__Homo_sapiens__AAA82748

<400>  1754
augagcugga gaggcagaag caccuacuac uggcccagac ccagaagaua cgugcagccc       60

cccgagguga ucggccccau gagacccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagaga caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccagcgccgg ccagggcccc aagcccgagg ccgacagcca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagaagc agagccagug cuga            354


<210>  1755
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-5__Homo_sapiens__AAA82748

<400>  1755
augagcugga gaggccgguc caccuacuau uggccccgcc cuagacggua cgugcagccg       60

cccgagguca ucgggccuau gcgccccgaa caauucucug acgagguuga accugccaca      120

cccgaggaag gagagccugc uacgcagaga caggacccgg ccgcggcuca ggagggcgaa      180

gacgaggggg ccagcgccgg acaaggcccc aagccugaag cugauuccca ggagcagggg      240

cacccccaga ccggaugcga gugugaagac ggcccugaug gccaagagau ggaucccccg      300

aacccugaag aggugaaaac acccgaagag ggggagaagc agucucagug cuga            354


<210>  1756
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-6__Homo_sapiens__Q13070

<400>  1756

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Val Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Val Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Lys Gln Ser Gln Cys 
        115         


<210>  1757
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-6__Homo_sapiens__AAA82749

<400>  1757
augaguuggc gaggaagauc gaccuauuau uggccuagac caaggcgcua uguacagccu       60

ccugaaguga uugggccuau gcggcccgag caguucagug augaagugga accagcaaca      120

ccugaagaag gggaaccagc aacucaacgu caggauccug cagcugcuca ggagggagag      180

gaugagggag caucugcagg ucaagggccg aagccugaag cugauagcca ggaacagggu      240

cacccacaga cuggguguga gugugaagau gguccugaug ggcaggaggu ggacccgcca      300

aauccagagg aggugaaaac gccugaagaa ggugaaaagc aaucacagug uuaa            354


<210>  1758
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-6__Homo_sapiens__AAA82749

<400>  1758
augagcuggc gcggccgguc caccuacuac uggccccgcc cgcggcgcua cgugcagccg       60

cccgagguca ucgggcccau gcggcccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacgcagcgc caggacccgg cggccgccca ggagggggag      180

gacgagggcg ccuccgccgg gcagggcccc aagcccgagg cggacagcca ggagcagggc      240

cacccccaga ccgggugcga gugcgaggac ggcccggacg ggcaggaggu ggacccgccc      300

aaccccgagg aggucaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1759
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-6__Homo_sapiens__AAA82749

<400>  1759
auguccuggc gcggccgcuc caccuacuac uggccccgcc cccgccgcua cguccagccc       60

cccgagguca ucggccccau gcgccccgag caguucuccg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagcgc caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccuccgccgg ccagggcccc aagcccgagg ccgacuccca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggaggu cgaccccccc      300

aaccccgagg aggucaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1760
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-6__Homo_sapiens__AAA82749

<400>  1760
augagcugga gaggcagguc caccuacuau uggccccggc cucgccgaua cgugcagcca       60

ccggagguca ucgggcccau gcguccugaa caauucucug acgagguuga accagccaca      120

cccgaggaag gagagccugc uacucagaga caggacccag cagccgcgca ggagggugaa      180

gacgagggcg cuucagccgg gcaaggaccc aagccugaag cagauaguca ggagcagggc      240

cacccacaga cggguugcga gugugaagac gggccggaug gacaagaggu ggaucccccu      300

aacccagaag agguaaaaac ccccgaagag ggcgagaagc agagccagug cuga            354


<210>  1761
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-6__Homo_sapiens__AAA82749

<400>  1761
augagcugga gaggcagaag caccuacuac uggcccagac ccagaagaua cgugcagccc       60

cccgagguga ucggccccau gagacccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagaga caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccagcgccgg ccagggcccc aagcccgagg ccgacagcca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggaggu ggaccccccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagaagc agagccagug cuga            354


<210>  1762
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-6__Homo_sapiens__AAA82749

<400>  1762
augagcugga gaggccgguc caccuacuau uggccccgcc cuagacggua cgugcagccg       60

cccgagguca ucgggccuau gcgccccgaa caauucucug acgagguuga accugccaca      120

cccgaggaag gagagccugc uacgcagaga caggacccgg ccgcggcuca ggagggcgaa      180

gacgaggggg ccagcgccgg acaaggcccc aagccugaag cugauuccca ggagcagggg      240

cacccccaga ccggaugcga gugugaagac ggcccugaug gccaagaggu ggaucccccg      300

aacccugaag aggugaaaac acccgaagag ggggagaagc agucucagug cuga            354


<210>  1763
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE7b__Homo_sapiens__O76087

<400>  1763

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala His Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Lys Gln Ser Gln Cys 
        115         


<210>  1764
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE7b__Homo_sapiens__AAC25989

<400>  1764
augaguuggc gaggaagauc gaccuauuau uggccuagac caaggcgcua uguacagccu       60

ccugaaauga uugggccuau gcggcccgag caguucagug augaagugga accagcaaca      120

ccugaagaag gggaaccagc aacucaacgu caggauccug cagcugcuca ggagggagag      180

gaugagggag caucugcagg ucaagggccg aagccugaag cucauagcca ggaacagggu      240

cacccacaga cuggguguga gugugaagau gguccugaug ggcaggagau ggacccgcca      300

aauccagagg aggugaaaac gccugaagaa ggugaaaagc aaucacagug uuaa            354


<210>  1765
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE7b__Homo_sapiens__AAC25989

<400>  1765
augagcuggc gcggccgguc caccuacuac uggccccgcc cgcggcgcua cgugcagccg       60

cccgagauga ucgggcccau gcggcccgag caguucagcg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacgcagcgc caggacccgg cggccgccca ggagggggag      180

gacgagggcg ccuccgccgg gcagggcccc aagcccgagg cgcacagcca ggagcagggc      240

cacccccaga ccgggugcga gugcgaggac ggcccggacg ggcaggagau ggacccgccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1766
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE7b__Homo_sapiens__AAC25989

<400>  1766
auguccuggc gcggccgcuc caccuacuac uggccccgcc cccgccgcua cguccagccc       60

cccgagauga ucggccccau gcgccccgag caguucuccg acgaggucga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagcgc caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccuccgccgg ccagggcccc aagcccgagg cccacuccca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggucaagac ccccgaggag ggcgagaagc agucccagug cuga            354


<210>  1767
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE7b__Homo_sapiens__AAC25989

<400>  1767
augagcugga gaggcagguc caccuacuau uggccccggc cucgccgaua cgugcagcca       60

ccggagauga ucgggcccau gcguccugaa caauucucug acgaggucga accagccaca      120

cccgaggaag gagagccugc uacucagaga caggauccag cagccgcgca ggagggugaa      180

gacgagggcg cuucagccgg gcaaggaccc aagccugaag cacacaguca ggagcagggc      240

cauccacaga cggguugcga gugugaagau gggccggacg gacaagagau ggaucccccu      300

aacccagaag agguuaaaac ccccgaagag ggcgagaagc agagccagug cuga            354


<210>  1768
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE7b__Homo_sapiens__AAC25989

<400>  1768
augagcugga gaggcagaag caccuacuac uggcccagac ccagaagaua cgugcagccc       60

cccgagauga ucggccccau gagacccgag caguucagcg acgaggugga gcccgccacc      120

cccgaggagg gcgagcccgc cacccagaga caggaccccg ccgccgccca ggagggcgag      180

gacgagggcg ccagcgccgg ccagggcccc aagcccgagg cccacagcca ggagcagggc      240

cacccccaga ccggcugcga gugcgaggac ggccccgacg gccaggagau ggaccccccc      300

aaccccgagg aggugaagac ccccgaggag ggcgagaagc agagccagug cuga            354


<210>  1769
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE7b__Homo_sapiens__AAC25989

<400>  1769
augagcugga gaggccgguc caccuacuau uggccccgcc cuagacggua cgugcagccg       60

cccgagauga ucgggccuau gcgccccgaa caauucucug acgaggucga accugccaca      120

cccgaggaag gagagccugc uacgcagaga caggauccgg ccgcggcuca ggagggcgaa      180

gacgaggggg ccagcgccgg acaaggcccc aagccugaag cucacuccca ggagcagggg      240

cauccccaga ccggaugcga gugugaagau ggcccugacg gccaagagau ggaucccccg      300

aacccugaag agguuaaaac acccgaagag ggggagaagc agucucagug cuga            354


<210>  1770
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GAGE-8_(GAGE-2D)__Homo_sapiens__Q9UEU5

<400>  1770

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly His 
65                  70                  75                  80  


Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu Lys 
            100                 105                 110         


Gln Ser Gln Cys 
        115     


<210>  1771
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1771
augaguuggc gaggaagauc gaccuaucgg ccuagaccaa gacgcuacgu agagccuccu       60

gaaaugauug ggccuaugcg gcccgagcag uucagugaug aaguggaacc agcaacaccu      120

gaagaagggg aaccagcaac ucaacgucag gauccugcag cugcucagga gggagaggau      180

gagggagcau cugcagguca agggccgaag ccugaagcug auagccagga acagggucac      240

ccacagacug ggugugagug ugaagauggu ccugaugggc aggagaugga cccgccaaau      300

ccagaggagg ugaaaacgcc ugaagaaggu gaaaagcaau cacaguguua a               351


<210>  1772
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1772
augagcuggc gcggccgguc caccuaccgc ccccggccgc gccgguacgu ggagccgccc       60

gagaugaucg ggcccaugcg ccccgagcag uucagcgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac gcagcggcag gacccggcgg ccgcccagga gggggaggac      180

gagggcgccu ccgccgggca gggccccaag cccgaggcgg acagccagga gcagggccac      240

ccccagaccg ggugcgagug cgaggacggc ccggacgggc aggagaugga cccgcccaac      300

cccgaggagg ugaagacccc cgaggagggc gagaagcagu cccagugcug a               351


<210>  1773
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1773
auguccuggc gcggccgcuc caccuaccgc ccccgccccc gccgcuacgu cgagcccccc       60

gagaugaucg gccccaugcg ccccgagcag uucuccgacg aggucgagcc cgccaccccc      120

gaggagggcg agcccgccac ccagcgccag gaccccgccg ccgcccagga gggcgaggac      180

gagggcgccu ccgccggcca gggccccaag cccgaggccg acucccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ucaagacccc cgaggagggc gagaagcagu cccagugcug a               351


<210>  1774
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1774
augagcugga gaggcagguc caccuaccgg ccccgcccuc gacguuaugu ggagccaccg       60

gaaaugaucg ggcccaugag accugagcag uucucugacg aagucgagcc agccacaccc      120

gaagagggag agccugcuac ucaaaggcag gacccagcag ccgcgcagga aggugaggac      180

gaaggcgcuu cagccgggca gggacccaag ccugaggcag auagucaaga gcagggccac      240

ccacagacgg guugcgaaug ugaggacggg ccggauggac aggaaaugga ucccccuaac      300

ccagaggaag uuaaaacccc cgaggagggc gaaaagcaaa gccagugcug a               351


<210>  1775
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1775
augagcugga gaggcagaag caccuacaga cccagaccca gaagauacgu ggagcccccc       60

gagaugaucg gccccaugag acccgagcag uucagcgacg agguggagcc cgccaccccc      120

gaggagggcg agcccgccac ccagagacag gaccccgccg ccgcccagga gggcgaggac      180

gagggcgcca gcgccggcca gggccccaag cccgaggccg acagccagga gcagggccac      240

ccccagaccg gcugcgagug cgaggacggc cccgacggcc aggagaugga cccccccaac      300

cccgaggagg ugaagacccc cgaggagggc gagaagcaga gccagugcug a               351


<210>  1776
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GAGE-8_(GAGE-2D)__Homo_sapiens__AAC33676

<400>  1776
augagcugga gaggccgguc caccuaccgc cccagaccuc ggcgcuaugu ggagccgccc       60

gaaaugaucg ggccuaugag acccgagcag uucucugacg aagucgagcc ugccacaccc      120

gaagagggag agccugcuac gcaacggcag gacccggccg cggcucagga aggcgaggac      180

gaaggggcca gcgccggaca gggccccaag ccugaggcug auucccaaga gcaggggcac      240

ccccagaccg gaugcgaaug ugaggacggc ccugauggcc aggaaaugga ucccccgaac      300

ccugaggaag uuaaaacacc cgaggagggg gaaaagcaau cucagugcug a               351


<210>  1777
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GASR__Homo_sapiens__P32239

<400>  1777

Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Thr Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Thr Arg Glu Leu Glu Leu Ala Ile Arg Ile Thr Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Thr Val Thr Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Thr Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Thr Phe Ile Phe Gly Thr Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Thr Leu Ser 
    130                 135                 140                 


Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 
145                 150                 155                 160 


Gln Ala Arg Val Trp Gln Thr Arg Ser His Ala Ala Arg Val Ile Val 
                165                 170                 175     


Ala Thr Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr 
            180                 185                 190         


Thr Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg 
        195                 200                 205             


Trp Pro Ser Ala Arg Val Arg Gln Thr Trp Ser Val Leu Leu Leu Leu 
    210                 215                 220                 


Leu Leu Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 
225                 230                 235                 240 


Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala 
            260                 265                 270         


Val His Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly Ala Val Gly Glu 
        275                 280                 285             


Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu 
    290                 295                 300                 


Glu Leu Thr Ala Leu Thr Ala Pro Gly Pro Gly Ser Gly Ser Arg Pro 
305                 310                 315                 320 


Thr Gln Ala Lys Leu Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu 
                325                 330                 335     


Val Ile Val Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 
            340                 345                 350         


Asn Thr Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 
        355                 360                 365             


Gly Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys 
    370                 375                 380                 


Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala 
385                 390                 395                 400 


Cys Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg 
                405                 410                 415     


Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Thr Pro Ser Ile Ala Ser 
            420                 425                 430         


Leu Ser Arg Leu Ser Tyr Thr Thr Ile Ser Thr Leu Gly Pro Gly 
        435                 440                 445         


<210>  1778
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GASR__Homo_sapiens__AAA35657

<400>  1778
auggagcugc uaaagcugaa ccggagcgug cagggaaccg gacccgggcc gggggcuucc       60

cugugccgcc cgggggcgcc ucuccucaac agcagcagug ugggcaaccu cagcugcgag      120

cccccucgca uucgcggagc cgggacacga gaauuggagc uggccauuag aaucacucuu      180

uacgcaguga ucuuccugau gagcguugga ggaaauaugc ucaucaucgu gguccuggga      240

cugagccgcc gccugaggac ugucaccaau gccuuccucc ucucacuggc agucagcgac      300

cuccugcugg cuguggcuug caugcccuuc acccuccugc ccaaucucau gggcacauuc      360

aucuuuggca ccgucaucug caaggcgguu uccuaccuca uggggguguc ugugagugug      420

uccacgcuaa gccucguggc caucgcacug gagcgguaca gcgccaucug ccgaccacug      480

caggcacgag uguggcagac gcgcucccac gcggcucgcg ugauuguagc cacguggcug      540

cuguccggac uacucauggu gcccuacccc guguacacug ucgugcaacc aguggggccu      600

cgugugcugc agugcgugca ucgcuggccc agugcgcggg uccgccagac cugguccgua      660

cugcugcuuc ugcucuuguu cuucaucccg ggugugguua uggccguggc cuacgggcuu      720

aucucucgcg agcucuacuu agggcuucgc uuugacggcg acagugacag cgacagccaa      780

agcagggucc gaaaccaagg cgggcugcca ggggcuguuc accagaacgg gcguugccgg      840

ccugagacug gcgcgguugg cgaagacagc gauggcugcu acgugcaacu uccacguucc      900

cggccugccc uggagcugac ggcgcugacg gcuccugggc cgggauccgg cucccggccc      960

acccaggcca agcugcuggc uaagaagcgc guggugcgaa uguugcuggu gaucguugug     1020

cuuuuuuuuc uguguugguu gccaguuuau agugccaaca cguggcgcgc cuuugauggc     1080

ccgggugcac accgagcacu cucgggugcu ccuaucuccu ucauucacuu gcugagcuac     1140

gccucggccu gugucaaccc ccuggucuac ugcuucaugc accgucgcuu ucgccaggcc     1200

ugccuggaaa cuugcgcucg cugcugcccc cggccuccac gagcucgccc cagggcucuu     1260

cccgaugagg acccucccac ucccuccauu gcuucgcugu ccaggcuuag cuacaccacc     1320

aucagcacac ugggcccugg cuga                                            1344


<210>  1779
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GASR__Homo_sapiens__AAA35657

<400>  1779
auggagcugc ucaagcugaa ccgcagcgug cagggcaccg ggcccggccc gggggccucc       60

cugugccggc ccggcgcgcc ccuccugaac agcuccagcg ucgggaaccu guccugcgag      120

cccccgcgca uccggggcgc cggcacccgc gagcucgagc uggccauccg gaucacgcug      180

uacgccguga ucuuccucau gagcgucggg ggcaacaugc ugaucaucgu ggugcugggg      240

cucucccgcc ggcugcgcac cgugaccaac gccuuccugc ucagccuggc cgucuccgac      300

cugcuccugg cgguggccug caugcccuuc acccugcucc ccaaccugau gggcacguuc      360

aucuucggga ccgugaucug caaggccguc agcuaccuga ugggcguguc cgugagcguc      420

uccacccuca gccugguggc caucgcgcug gagcgguacu ccgccaucug ccgcccccuc      480

caggcccggg uguggcagac ccgcagccac gccgcccggg ucaucguggc gacguggcug      540

cuguccggcc uccugauggu gccguacccc gucuacaccg uggugcagcc cgucgggccc      600

cgcgugcugc agugcgugca ccgguggccg agcgcccgcg uccggcagac cugguccgug      660

cuccugcugc uccugcuguu cuucaucccc ggcgucguga uggccguggc cuacgggcuc      720

aucagccgcg agcuguaccu gggccuccgg uucgacggcg acagcgacuc cgacagccag      780

ucccgcgucc ggaaccaggg cgggcugccc ggggccgugc accagaacgg ccgcugccgc      840

cccgagaccg gggcgguggg cgaggacagc gacggcugcu acguccagcu gccgcggucc      900

cgccccgccc ucgagcugac ggcccugacc gcccccgggc ccggcagcgg gucccggccg      960

acccaggcca agcuccuggc gaagaagcgc guggugcgga ugcugcuggu caucguggug     1020

cuguucuucc ugugcuggcu gcccgucuac agcgccaaca ccuggcgcgc cuucgacggc     1080

cccggggccc accgggcccu cuccggcgcg cccaucagcu ucauccaccu ccuguccuac     1140

gccagcgccu gcgugaaccc gcucguguac ugcuucaugc accgccgguu ccgccaggcc     1200

ugccuggaga cgugcgcgcg gugcugcccc cgcccgcccc gggcccgccc ccgggcccug     1260

cccgacgagg acccgcccac ccccuccauc gccagccucu cccgccugag cuacaccacc     1320

aucuccacgc ugggccccgg guga                                            1344


<210>  1780
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GASR__Homo_sapiens__AAA35657

<400>  1780
auggagcucc ucaagcucaa ccgcuccguc cagggcaccg gccccggccc cggcgccucc       60

cucugccgcc ccggcgcccc ccuccucaac uccuccuccg ucggcaaccu cuccugcgag      120

cccccccgca uccgcggcgc cggcacccgc gagcucgagc ucgccauccg caucacccuc      180

uacgccguca ucuuccucau guccgucggc ggcaacaugc ucaucaucgu cguccucggc      240

cucucccgcc gccuccgcac cgucaccaac gccuuccucc ucucccucgc cgucuccgac      300

cuccuccucg ccgucgccug caugcccuuc acccuccucc ccaaccucau gggcaccuuc      360

aucuucggca ccgucaucug caaggccguc uccuaccuca ugggcgucuc cgucuccguc      420

uccacccucu cccucgucgc caucgcccuc gagcgcuacu ccgccaucug ccgcccccuc      480

caggcccgcg ucuggcagac ccgcucccac gccgcccgcg ucaucgucgc caccuggcuc      540

cucuccggcc uccucauggu ccccuacccc gucuacaccg ucguccagcc cgucggcccc      600

cgcguccucc agugcgucca ccgcuggccc uccgcccgcg uccgccagac cugguccguc      660

cuccuccucc uccuccucuu cuucaucccc ggcgucguca uggccgucgc cuacggccuc      720

aucucccgcg agcucuaccu cggccuccgc uucgacggcg acuccgacuc cgacucccag      780

ucccgcgucc gcaaccaggg cggccucccc ggcgccgucc accagaacgg ccgcugccgc      840

cccgagaccg gcgccgucgg cgaggacucc gacggcugcu acguccagcu cccccgcucc      900

cgccccgccc ucgagcucac cgcccucacc gcccccggcc ccggcuccgg cucccgcccc      960

acccaggcca agcuccucgc caagaagcgc gucguccgca ugcuccucgu caucgucguc     1020

cucuucuucc ucugcuggcu ccccgucuac uccgccaaca ccuggcgcgc cuucgacggc     1080

cccggcgccc accgcgcccu cuccggcgcc cccaucuccu ucauccaccu ccucuccuac     1140

gccuccgccu gcgucaaccc ccucgucuac ugcuucaugc accgccgcuu ccgccaggcc     1200

ugccucgaga ccugcgcccg cugcugcccc cgcccccccc gcgcccgccc ccgcgcccuc     1260

cccgacgagg acccccccac ccccuccauc gccucccucu cccgccucuc cuacaccacc     1320

aucuccaccc ucggccccgg cuga                                            1344


<210>  1781
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GASR__Homo_sapiens__AAA35657

<400>  1781
auggagcugc ucaaacuuaa cagaagcgug cagggcaccg ggcccggacc uggugccucc       60

cugugcaggc caggcgcucc guuguuaaau ucuucaagug ucgggaaccu gagcugugaa      120

cccccucgga uccgcggagc aggcacacga gagcuagaac ucgccauucg uauaacucug      180

uacgcgguua ucuuccuuau guccgugggu gggaauaugc ugauuaucgu aguguuggga      240

cucucuagaa ggcugcggac ggucaccaac gcuuuucugc ucucguuagc cgugucagac      300

cugcuuuugg caguugccug caugccauuc acacugcuac ccaaucucau gggcacuuuu      360

auuuucggca ccgugaucug uaaggcuguc agcuaucuga ugggggugag uguauccguu      420

ucuacacuua gccugguggc aauagccuug gagcgcuacu ccgcuaucug cagaccucuc      480

caagccaggg ucuggcagac ccggucacac gcggcacgcg ugauuguggc cacuuggcug      540

uuaaguggac ugcucauggu cccauauccc guuuacacag ugguacagcc ugugggucca      600

cgaguccuuc agugugugca uagauggccg agcgcuaggg uucggcaaac cuggucugug      660

cuguugcuac ugcuccuguu uuucaucccc ggcgucguga uggccguagc auaugggcuu      720

auuucccgug aacuguacuu gggacuccgc uuugauggcg acucagauag cgacagucag      780

ucuagaguua ggaaccaggg ugggcugccu ggagcugugc accagaaugg ccggugccga      840

ccagagacgg gcgccgucgg ggaggauucc gacggauguu augugcaauu accccgcagc      900

agaccugcgc uggaacuaac ugcccucacc gcaccagguc ccggcucggg gucuaggccg      960

acacaggcua agcugcuugc caaaaagcgg gucgugcgca uguugcuggu uaucguggua     1020

cucuucuuuc ugugcuggcu uccugucuac uccgcuaaca cuuggagagc cuucgaugga     1080

cccggcgcac auagggcccu gucaggugcu ccaauaaguu uuauucacuu gcucagcuac     1140

gcguccgcau gugugaaucc ucugguuuau ugcuucaugc aucgucgguu ucgacaggcc     1200

uguuuagaga ccugcgcuag augcuguccc aggccacccc gcgcccggcc uagagcacug     1260

ccagacgaag auccgcccac accuucuauc gccagccuau caaggcucag uuacaccacg     1320

auuuccacuc uggggccagg cuga                                            1344


<210>  1782
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GASR__Homo_sapiens__AAA35657

<400>  1782
auggagcugc ugaagcugaa cagaagcgug cagggcaccg gccccggccc cggcgccagc       60

cugugcagac ccggcgcccc ccugcugaac agcagcagcg ugggcaaccu gagcugcgag      120

ccccccagaa ucagaggcgc cggcaccaga gagcuggagc uggccaucag aaucacccug      180

uacgccguga ucuuccugau gagcgugggc ggcaacaugc ugaucaucgu ggugcugggc      240

cugagcagaa gacugagaac cgugaccaac gccuuccugc ugagccuggc cgugagcgac      300

cugcugcugg ccguggccug caugcccuuc acccugcugc ccaaccugau gggcaccuuc      360

aucuucggca ccgugaucug caaggccgug agcuaccuga ugggcgugag cgugagcgug      420

agcacccuga gccugguggc caucgcccug gagagauaca gcgccaucug cagaccccug      480

caggccagag uguggcagac cagaagccac gccgccagag ugaucguggc caccuggcug      540

cugagcggcc ugcugauggu gcccuacccc guguacaccg uggugcagcc cgugggcccc      600

agagugcugc agugcgugca cagauggccc agcgccagag ugagacagac cuggagcgug      660

cugcugcugc ugcugcuguu cuucaucccc ggcgugguga uggccguggc cuacggccug      720

aucagcagag agcuguaccu gggccugaga uucgacggcg acagcgacag cgacagccag      780

agcagaguga gaaaccaggg cggccugccc ggcgccgugc accagaacgg cagaugcaga      840

cccgagaccg gcgccguggg cgaggacagc gacggcugcu acgugcagcu gcccagaagc      900

agacccgccc uggagcugac cgcccugacc gcccccggcc ccggcagcgg cagcagaccc      960

acccaggcca agcugcuggc caagaagaga guggugagaa ugcugcuggu gaucguggug     1020

cuguucuucc ugugcuggcu gcccguguac agcgccaaca ccuggagagc cuucgacggc     1080

cccggcgccc acagagcccu gagcggcgcc cccaucagcu ucauccaccu gcugagcuac     1140

gccagcgccu gcgugaaccc ccugguguac ugcuucaugc acagaagauu cagacaggcc     1200

ugccuggaga ccugcgccag augcugcccc agacccccca gagccagacc cagagcccug     1260

cccgacgagg acccccccac ccccagcauc gccagccuga gcagacugag cuacaccacc     1320

aucagcaccc ugggccccgg cuga                                            1344


<210>  1783
<211>  1344
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GASR__Homo_sapiens__AAA35657

<400>  1783
auggagcugc ucaagcugaa cagaagcgug cagggcaccg ggcccggacc uggcgccucc       60

cuuugccggc cgggggcucc ccugcucaau ucuagcuccg ucggaaaccu gucuugugaa      120

ccuccccgca ucagaggcgc cgggacacgg gagcuugaac uggcgauucg caucacgcuc      180

uacgcuguua uuuuccugau gagcguggga ggcaauaugc ugaucauugu gguccucggc      240

cuguccagac ggcuucgcac cgugacaaac gccuuucugc ucucucuggc cguuagcgac      300

cuucugcucg cuguggccug caugccuuuc acccugcugc ccaaucucau ggggacauuu      360

aucuucggaa ccgucaucug uaaagcugug uccuaucuga ugggcguuag cgugucuguc      420

uccacacuua gccugguggc cauugcgcuc gagagauacu cugccaucug ccggccucug      480

caagcucgcg uguggcagac cagaucccac gccgcucggg ucauuguugc cacguggcuu      540

cugagcgggc uccugauggu gccguauccc guguacaccg ucgugcagcc uguuggaccc      600

cgcgugcugc agugugucca uagauggccu ucugcgcggg ugcgccaaac augguccguu      660

cuccugcuuc ugcuccuguu uuucaucccc ggcgugguca uggccguggc uuaugggcuu      720

auuagcagag aacuguaccu cggacugcgg uuugauggcg acuccgauuc ugacagccag      780

uccagagucc gcaaccaggg cgggcugccg ggagccgugc accagaaugg ccggugcaga      840

ccugagaccg gggcuguugg agaggauagc gacggcuguu augugcaacu cccccgcucu      900

cggccugccc uggaacuuac agcccugacc gcucccgggc ccggauccgg cagcagaccu      960

acgcaggcga agcuccuggc caaaaagcgc gucgugcgga ugcugcuugu uaucgugguc     1020

cucuucuuuc ugugcuggcu gccgguguac ucugcuaaca cauggagagc cuucgauggc     1080

cccggggccc aucgcgcucu cagcggagcc ccuauuuccu uuauccaucu gcuuucuuac     1140

gcgagcgcuu gugugaaucc ccugguuuau ugcuucaugc accggagauu ucgccaggcc     1200

ugucucgaga ccugcgcccg gugcuguccu agacccccgc gggcucgccc uagagcccug     1260

cccgacgaag auccucccac accuuccauc gcuagccugu cucggcuuuc cuacaccacc     1320

auuagcacac ucggccccgg guga                                            1344


<210>  1784
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GnT-V__Homo_sapiens__Q09328

<400>  1784

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg 
                85                  90                  95      


Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr 
            100                 105                 110         


Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala 
        115                 120                 125             


Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys 
    130                 135                 140                 


Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile 
145                 150                 155                 160 


Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr 
                165                 170                 175     


Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val 
            180                 185                 190         


Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu 
        195                 200                 205             


Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile 
    210                 215                 220                 


Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu 
225                 230                 235                 240 


Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val 
            260                 265                 270         


His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr 
        275                 280                 285             


Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu 
    290                 295                 300                 


Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser 
305                 310                 315                 320 


Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser 
                325                 330                 335     


Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp 
            340                 345                 350         


Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val 
        355                 360                 365             


His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro 
    370                 375                 380                 


Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro 
385                 390                 395                 400 


Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro 
                405                 410                 415     


His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu 
            420                 425                 430         


Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln 
        435                 440                 445             


Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile 
    450                 455                 460                 


Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr 
465                 470                 475                 480 


Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile 
                485                 490                 495     


Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe 
            500                 505                 510         


Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
        515                 520                 525             


Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser 
    530                 535                 540                 


Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu 
545                 550                 555                 560 


Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val 
                565                 570                 575     


Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys 
            580                 585                 590         


Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr 
        595                 600                 605             


Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp 
    610                 615                 620                 


Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val 
625                 630                 635                 640 


Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser 
                645                 650                 655     


Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys 
            660                 665                 670         


Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys 
        675                 680                 685             


Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe 
    690                 695                 700                 


Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His 
705                 710                 715                 720 


Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu 
                725                 730                 735     


Cys Lys Asp Cys Leu 
            740     


<210>  1785
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GnT-V__Homo_sapiens__AAD22449

<400>  1785
auggcucucu ucacuccgug gaaguugucc ucucagaagc ugggcuuuuu ccuggugacu       60

uuuggcuuca uuugggguau gaugcuucug cacuuuacca uccagcagcg aacucagccu      120

gaaagcagcu ccaugcugcg cgagcagauc cuggaccuca gcaaaaggua caucaaggca      180

cuggcagaag aaaacaggaa ugugguggau gggccauacg cuggagucau gacagcuuau      240

gaucugaaga aaacccuugc uguguuauua gauaacauuu ugcagcgcau uggcaaguug      300

gagucgaagg uggacaaucu uguugucaau ggcaccggaa caaacucaac caacuccacu      360

acagcuguuc ccagcuuggu ugcacuugag aaaauuaaug uggcagauau cauuaacgga      420

gcucaagaaa aauguguauu gccuccuaug gacggcuacc cucacuguga gggaaagauc      480

aaguggauga aagacaugug gcguucagau cccugcuacg cagacuaugg aguggaugga      540

uccaccugcu cuuuuuuuau uuaccucagu gagguugaaa auuggugucc ucauuuaccu      600

uggagagcaa aaaaucccua cgaagaagcu gaucauaauu cauuggcgga aauucguaca      660

gauuuuaaua uucucuacag uaugaugaaa aagcaugaag aauuccggug gaugagacua      720

cggauccggc gaauggcuga cgcauggauc caagcaauca agucccuggc agaaaagcag      780

aaccuugaaa agagaaagcg gaagaaaguc cucguucacc ugggacuccu gaccaaggaa      840

ucuggauuua agauugcaga gacagcuuuc agugguggcc cucuugguga auuaguucaa      900

uggagugauu uaauuacauc ucuguacuua cugggccaug acauuaggau uucagcuuca      960

cuggcugagc ucaaggaaau caugaagaag guuguaggaa accgaucugg cugcccaacu     1020

guaggagaca gaauuguuga gcucauuuac auugauauug uaggacuugc ucaauucaag     1080

aaaacucuug gaccauccug gguucauuac cagugcaugc uccgagugcu ggauuccuuu     1140

ggaacagaac cugaguucaa ucacgcaaau uaugcccaau cgaaaggcca caagaccccu     1200

uggggaaaau ggaaucugaa cccucagcag uuuuauacca uguucccuca uaccccagac     1260

aacagcuuuc ugggguuugu gguugagcag caccugaacu ccagugauau ccaccacauu     1320

aaugaaauca aaaggcagaa ccagucccuu guguauggca aaguggauag cuucuggaag     1380

aauaagaaga ucuacuugga cauuauucac acauacaugg aagugcaugc aacuguuuau     1440

ggcuccagca caaagaauau ucccaguuac gugaaaaacc augguauccu caguggacgg     1500

gaccugcagu uccuucuucg agaaaccaag uuguuuguug gacuuggguu cccuuacgag     1560

ggcccagcuc cccuggaagc uaucgcaaau ggaugugcuu uucugaaucc caaguucaac     1620

ccacccaaaa gcagcaaaaa cacagacuuc uucauuggca agccaacacu gagagagcuc     1680

acaucccagc auccuuacgc ugaaguuuuc aucgggcggc cacaugugug gacuguugac     1740

cucaacaauc aggaggaagu agaggaugca gugaaagcca ucuuaaacca gaagauugag     1800

ccauacaugc cauaugaauu uacgugcgag gggaugcuac agagaaucaa ugcuuucauu     1860

gaaaaacagg acuucugcca ugggcaagug auguggccac cccucagcgc ccuacagguc     1920

aagcuugcug agcccgggca guccugcaag caggugugcc aggagagcca gcucaucugc     1980

gagccuucuu ucuuccagca ccucaacaag gacaaggaca ugcugaagua caaggugacc     2040

ugccaaagcu cagagcuggc caaggacauc cuggugcccu ccuuugaccc uaagaauaag     2100

cacugugugu uucaagguga ccuccugcuc uucagcugug caggcgccca ccccaggcac     2160

cagagggucu gccccugccg ggacuucauc aagggccagg uggcucucug caaagacugc     2220

cuauag                                                                2226


<210>  1786
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GnT-V__Homo_sapiens__AAD22449

<400>  1786
auggcccugu ucacccccug gaagcucagc ucccagaagc ugggguucuu ccuggugacc       60

uucggguuca ucuggggcau gaugcuccug cacuucacga uccagcagcg cacccagccg      120

gagagcucca gcaugcugcg ggagcagauc cucgaccugu ccaagcgcua caucaaggcc      180

cuggcggagg agaaccggaa cgucguggac gggcccuacg ccggcgugau gaccgccuac      240

gaccucaaga agacccuggc cguccugcuc gacaacaucc ugcagcgcau cgggaagcug      300

gagagcaagg uggacaaccu cguggucaac ggcacgggca ccaacuccac caacagcacc      360

acggccgugc ccucccuggu ggcgcuggag aagaucaacg ucgccgacau caucaacggg      420

gcccaggaga agugcgugcu gcccccgaug gacggcuacc cccacugcga ggggaagauc      480

aaguggauga aggacaugug gcggagcgac cccugcuacg ccgacuacgg cguggacggg      540

uccacgugca gcuucuucau cuaccugucc gaggucgaga acuggugccc ccaccucccg      600

uggcgcgcga agaaccccua cgaggaggcc gaccacaaca gccucgccga gauccggacc      660

gacuucaaca uccuguacuc caugaugaag aagcacgagg aguuccgcug gaugcggcug      720

cgcauccggc gcauggccga cgccuggauc caggcgauca agagccucgc cgagaagcag      780

aaccuggaga agcggaagcg caagaaggug cuggugcacc ucggccugcu gaccaaggag      840

uccggcuuca agaucgccga gaccgccuuc agcgggggcc cccucgggga gcugguccag      900

ugguccgacc ugaucaccag ccucuaccug cugggccacg acauccggau cagcgccucc      960

cucgcggagc ugaaggagau caugaagaag guggugggca accgcagcgg gugccccacc     1020

gucggcgacc ggaucgugga gcugaucuac aucgacaucg uggggcucgc ccaguucaag     1080

aagacccugg gcccguccug gguccacuac cagugcaugc ugcgcgugcu cgacagcuuc     1140

gggacggagc ccgaguucaa ccacgccaac uacgcccagu ccaagggcca caagaccccc     1200

uggggcaagu ggaaccugaa cccccagcag uucuacacca uguucccgca cacccccgac     1260

aacagcuucc ugggguucgu ggucgagcag caccucaacu ccagcgacau ccaccacauc     1320

aacgagauca agcggcagaa ccagucccug guguacggca aggucgacag cuucuggaag     1380

aacaagaaga ucuaccugga caucauccac acguacaugg aggugcacgc caccguguac     1440

ggguccagca ccaagaacau ccccuccuac gucaagaacc acggcauccu cagcgggcgc     1500

gaccugcagu uccugcugcg ggagaccaag cuguucgugg gccugggcuu ccccuacgag     1560

gggccggcgc cccuggaggc caucgccaac ggcugcgccu uccucaaccc caaguucaac     1620

ccgcccaagu ccagcaagaa cacggacuuc uucaucggga agcccacccu gcgcgagcug     1680

accucccagc accccuacgc cgagguguuc aucggccgcc cccacgucug gaccguggac     1740

cucaacaacc aggaggaggu ggaggacgcg gucaaggcca uccugaacca gaagaucgag     1800

ccguacaugc ccuacgaguu cacgugcgag gggaugcugc agcggaucaa cgccuucauc     1860

gagaagcagg acuucugcca cggccaggug auguggcccc cgcucagcgc ccuccaggug     1920

aagcuggcgg agcccggcca guccugcaag caggucugcc aggagagcca gcucaucugc     1980

gagcccagcu ucuuccagca ccugaacaag gacaaggaca ugcugaagua caaggugacc     2040

ugccagucca gcgagcucgc caaggacauc cuggugcccu ccuucgaccc gaagaacaag     2100

cacugcgucu uccaggggga ccugcuccug uucagcugcg ccggcgccca cccccgccac     2160

cagcgggugu gccccugccg cgacuucauc aagggccagg uggcccugug caaggacugc     2220

cucuga                                                                2226


<210>  1787
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GnT-V__Homo_sapiens__AAD22449

<400>  1787
auggcccucu ucacccccug gaagcucucc ucccagaagc ucggcuucuu ccucgucacc       60

uucggcuuca ucuggggcau gaugcuccuc cacuucacca uccagcagcg cacccagccc      120

gaguccuccu ccaugcuccg cgagcagauc cucgaccucu ccaagcgcua caucaaggcc      180

cucgccgagg agaaccgcaa cgucgucgac ggccccuacg ccggcgucau gaccgccuac      240

gaccucaaga agacccucgc cguccuccuc gacaacaucc uccagcgcau cggcaagcuc      300

gaguccaagg ucgacaaccu cgucgucaac ggcaccggca ccaacuccac caacuccacc      360

accgccgucc ccucccucgu cgcccucgag aagaucaacg ucgccgacau caucaacggc      420

gcccaggaga agugcguccu cccccccaug gacggcuacc cccacugcga gggcaagauc      480

aaguggauga aggacaugug gcgcuccgac cccugcuacg ccgacuacgg cgucgacggc      540

uccaccugcu ccuucuucau cuaccucucc gaggucgaga acuggugccc ccaccucccc      600

uggcgcgcca agaaccccua cgaggaggcc gaccacaacu cccucgccga gauccgcacc      660

gacuucaaca uccucuacuc caugaugaag aagcacgagg aguuccgcug gaugcgccuc      720

cgcauccgcc gcauggccga cgccuggauc caggccauca agucccucgc cgagaagcag      780

aaccucgaga agcgcaagcg caagaagguc cucguccacc ucggccuccu caccaaggag      840

uccggcuuca agaucgccga gaccgccuuc uccggcggcc cccucggcga gcucguccag      900

ugguccgacc ucaucaccuc ccucuaccuc cucggccacg acauccgcau cuccgccucc      960

cucgccgagc ucaaggagau caugaagaag gucgucggca accgcuccgg cugccccacc     1020

gucggcgacc gcaucgucga gcucaucuac aucgacaucg ucggccucgc ccaguucaag     1080

aagacccucg gccccuccug gguccacuac cagugcaugc uccgcguccu cgacuccuuc     1140

ggcaccgagc ccgaguucaa ccacgccaac uacgcccagu ccaagggcca caagaccccc     1200

uggggcaagu ggaaccucaa cccccagcag uucuacacca uguuccccca cacccccgac     1260

aacuccuucc ucggcuucgu cgucgagcag caccucaacu ccuccgacau ccaccacauc     1320

aacgagauca agcgccagaa ccagucccuc gucuacggca aggucgacuc cuucuggaag     1380

aacaagaaga ucuaccucga caucauccac accuacaugg agguccacgc caccgucuac     1440

ggcuccucca ccaagaacau ccccuccuac gucaagaacc acggcauccu cuccggccgc     1500

gaccuccagu uccuccuccg cgagaccaag cucuucgucg gccucggcuu ccccuacgag     1560

ggccccgccc cccucgaggc caucgccaac ggcugcgccu uccucaaccc caaguucaac     1620

ccccccaagu ccuccaagaa caccgacuuc uucaucggca agcccacccu ccgcgagcuc     1680

accucccagc accccuacgc cgaggucuuc aucggccgcc cccacgucug gaccgucgac     1740

cucaacaacc aggaggaggu cgaggacgcc gucaaggcca uccucaacca gaagaucgag     1800

cccuacaugc ccuacgaguu caccugcgag ggcaugcucc agcgcaucaa cgccuucauc     1860

gagaagcagg acuucugcca cggccagguc auguggcccc cccucuccgc ccuccagguc     1920

aagcucgccg agcccggcca guccugcaag caggucugcc aggaguccca gcucaucugc     1980

gagcccuccu ucuuccagca ccucaacaag gacaaggaca ugcucaagua caaggucacc     2040

ugccaguccu ccgagcucgc caaggacauc cucguccccu ccuucgaccc caagaacaag     2100

cacugcgucu uccagggcga ccuccuccuc uucuccugcg ccggcgccca cccccgccac     2160

cagcgcgucu gccccugccg cgacuucauc aagggccagg ucgcccucug caaggacugc     2220

cucuga                                                                2226


<210>  1788
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GnT-V__Homo_sapiens__AAD22449

<400>  1788
auggcccugu ucacccccug gaagcucagc ucccagaaac uuggcuuuuu ccuggugaca       60

uuuggguuca ucuggggaau gauguuguua cacuuuacua uucaacagag aacgcagccu      120

gagucuucaa guaugcugag ggaacagaua cuagaccuca gcaagcggua caucaaagcu      180

cuggcagagg aaaaccgcaa ugucguugau gguccauaug ccggcgugau gaccgcguac      240

gaccuuaaga aaacacuggc uguauugcuc gauaacauuc ugcaacgaau cgggaagcug      300

gaguccaagg uggacaaucu cgucgugaac ggaacuggca ccaauucuac aaacucgacc      360

acugccguuc cgucauuagu ggcacuggaa aagauuaaug ucgccgauau cauaaacggu      420

gcucaggaga agugcgugcu ucccccuaug gacggguauc cacauuguga gggaaaaauc      480

aaguggauga aagauaugug gcguagcgac cccugcuacg cagauuaugg cguagacggc      540

aguacauguu ccuucuuuau uuacuugucu gaaguugaga auuggugccc ucaucugcca      600

uggagagcca agaaccccua ugaagaggcu gaucacaaua gccuagccga gaucaggacc      660

gacuucaaca uucucuacuc caugaugaag aaacacgaag aguuucggug gaugcgccug      720

agaaucaggc ggauggcgga ugcauggaua caggccauua agucacuugc ugaaaaacag      780

aaucuggaga agcgcaaacg aaagaaagug uugguccauc ucgggcuguu aacgaaggaa      840

aguggauuca agaucgccga gacugcauuu agcgguggcc cucuggggga gcucgugcaa      900

uggucugacc uuauuaccuc ccuguacuug cuaggacacg acaucagaau cucagcuagc      960

cuggccgaac ucaaagagau uaugaagaaa guggucggca acaggagugg uuguccaaca     1020

guuggggauc ggauagugga acugaucuau auugacaucg uaggacuugc gcaguucaag     1080

aaaacucugg gcccgucuug ggugcacuac cagugcaugu ugcguguccu cgauuccuuu     1140

ggcaccgagc ccgaguucaa ucaugccaac uaugcacaga gcaaggggca caagacaccu     1200

uggggaaaau ggaaccugaa uccacaacag uucuacacca uguuucccca uacgccugac     1260

aacucguucu uagguuuugu gguugaacag caccuuaauu cuuccgauau acaccauauu     1320

aacgagauca agcgccaaaa ucagagucua guguauggca aagucgacag uuucuggaag     1380

aacaaaaaga ucuaccucga uauuauccac acuuauaugg aagugcaugc uacaguauac     1440

gggagcucca ccaagaauau uccaucuuac guuaaaaacc acggaauacu gagcggcaga     1500

gaccuucagu uuuugcugag ggagacuaaa cucuucgugg gucugggguu ucccuaugaa     1560

ggcccggccc cucuugaggc uaucgccaau ggaugugcau uccugaaccc caaauuuaau     1620

ccaccuaagu caaguaaaaa cacagauuuc uuuauuggca agcccaccuu gcgggaacuc     1680

acgucccagc auccauacgc cgaggucuuc aucgggcgac cccacgugug gaccgucgac     1740

cugaauaacc aagaggaagu ggaggaugcu guuaaggcga ucuuaaauca gaaaauugaa     1800

ccuuauaugc cauacgaguu uacaugcgag ggaaugcugc agcgcauaaa cgcauucauc     1860

gaaaagcagg acuucuguca cggucaagug auguggccgc cccuaagcgc ccuccaggua     1920

aaacuggcug agccuggcca gucuugcaag caggucuguc aagaaucaca gcuuauuugc     1980

gagccaucau uuuuccagca uuugaacaaa gacaaggaua ugcugaaaua uaaggugacu     2040

ugccagagcu ccgaacucgc caaggacauc cugguucccu cuuuugaucc uaaaaauaag     2100

cacugugugu uccaagggga cuuacugcug uuuucgugcg caggagccca uccaagacac     2160

cagagggucu gucccugccg ggauuucauu aaaggccagg uggcuuugug uaaggacugc     2220

cucuga                                                                2226


<210>  1789
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GnT-V__Homo_sapiens__AAD22449

<400>  1789
auggcccugu ucacccccug gaagcugagc agccagaagc ugggcuucuu ccuggugacc       60

uucggcuuca ucuggggcau gaugcugcug cacuucacca uccagcagag aacccagccc      120

gagagcagca gcaugcugag agagcagauc cuggaccuga gcaagagaua caucaaggcc      180

cuggccgagg agaacagaaa cgugguggac ggccccuacg ccggcgugau gaccgccuac      240

gaccugaaga agacccuggc cgugcugcug gacaacaucc ugcagagaau cggcaagcug      300

gagagcaagg uggacaaccu gguggugaac ggcaccggca ccaacagcac caacagcacc      360

accgccgugc ccagccuggu ggcccuggag aagaucaacg uggccgacau caucaacggc      420

gcccaggaga agugcgugcu gccccccaug gacggcuacc cccacugcga gggcaagauc      480

aaguggauga aggacaugug gagaagcgac cccugcuacg ccgacuacgg cguggacggc      540

agcaccugca gcuucuucau cuaccugagc gagguggaga acuggugccc ccaccugccc      600

uggagagcca agaaccccua cgaggaggcc gaccacaaca gccuggccga gaucagaacc      660

gacuucaaca uccuguacag caugaugaag aagcacgagg aguucagaug gaugagacug      720

agaaucagaa gaauggccga cgccuggauc caggccauca agagccuggc cgagaagcag      780

aaccuggaga agagaaagag aaagaaggug cuggugcacc ugggccugcu gaccaaggag      840

agcggcuuca agaucgccga gaccgccuuc agcggcggcc cccugggcga gcuggugcag      900

uggagcgacc ugaucaccag ccuguaccug cugggccacg acaucagaau cagcgccagc      960

cuggccgagc ugaaggagau caugaagaag guggugggca acagaagcgg cugccccacc     1020

gugggcgaca gaaucgugga gcugaucuac aucgacaucg ugggccuggc ccaguucaag     1080

aagacccugg gccccagcug ggugcacuac cagugcaugc ugagagugcu ggacagcuuc     1140

ggcaccgagc ccgaguucaa ccacgccaac uacgcccaga gcaagggcca caagaccccc     1200

uggggcaagu ggaaccugaa cccccagcag uucuacacca uguuccccca cacccccgac     1260

aacagcuucc ugggcuucgu gguggagcag caccugaaca gcagcgacau ccaccacauc     1320

aacgagauca agagacagaa ccagagccug guguacggca agguggacag cuucuggaag     1380

aacaagaaga ucuaccugga caucauccac accuacaugg aggugcacgc caccguguac     1440

ggcagcagca ccaagaacau ccccagcuac gugaagaacc acggcauccu gagcggcaga     1500

gaccugcagu uccugcugag agagaccaag cuguucgugg gccugggcuu ccccuacgag     1560

ggccccgccc cccuggaggc caucgccaac ggcugcgccu uccugaaccc caaguucaac     1620

ccccccaaga gcagcaagaa caccgacuuc uucaucggca agcccacccu gagagagcug     1680

accagccagc accccuacgc cgagguguuc aucggcagac cccacgugug gaccguggac     1740

cugaacaacc aggaggaggu ggaggacgcc gugaaggcca uccugaacca gaagaucgag     1800

cccuacaugc ccuacgaguu caccugcgag ggcaugcugc agagaaucaa cgccuucauc     1860

gagaagcagg acuucugcca cggccaggug auguggcccc cccugagcgc ccugcaggug     1920

aagcuggccg agcccggcca gagcugcaag caggugugcc aggagagcca gcugaucugc     1980

gagcccagcu ucuuccagca ccugaacaag gacaaggaca ugcugaagua caaggugacc     2040

ugccagagca gcgagcuggc caaggacauc cuggugccca gcuucgaccc caagaacaag     2100

cacugcgugu uccagggcga ccugcugcug uucagcugcg ccggcgccca ccccagacac     2160

cagagagugu gccccugcag agacuucauc aagggccagg uggcccugug caaggacugc     2220

cuguga                                                                2226


<210>  1790
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GnT-V__Homo_sapiens__AAD22449

<400>  1790
auggcccugu ucacccccug gaagcucagc ucccagaaac ugggcuuuuu ccuugugaca       60

uuuggguuca ucuggggaau gaugcugcuc cacuuuacga uucaacagag aacccagccu      120

gagucuagcu ccaugcugcg ggaacagauc cuugaccugu cuaagcgcua cauuaaagcu      180

cucgccgagg aaaacagaaa ugucguugau ggcccguaug cgggggugau gacagcuuac      240

gaccugaaga aaacccuggc cgugcuccug gauaacaucc uucaacggau uggaaagcug      300

gagagcaagg ucgacaaucu cgugguuaac ggcacaggga ccaauuccac aaacucuacc      360

acggccgugc ccagccuggu cgcucuugaa aagaucaaug uggccgauau cauuaacgga      420

gcucaggaga agugcguucu gccucccaug gacggcuauc cucauuguga gggcaaaauc      480

aaguggauga aagauaugug gcgcuccgac cccugcuacg ccgauuaugg gguggacgga      540

agcaccuguu cuuucuuuau uuaccucucc gaagucgaga auuggugccc ucaccucccg      600

uggagagcga agaaccccua ugaagaggcc gaucauaaua gccuggcuga gauccggaca      660

gacuucaaca uucucuacuc uaugaugaag aaacacgaag aguuucgcug gaugagacug      720

cggauccgca gaauggccga ugcuuggauu caggccauca agucccuugc ggaaaaacag      780

aaucuggaga agcggaaacg caagaaagug cucgugcauc ugggccuucu gaccaaggaa      840

agcggguuca agaucgccga gacagcuuuu ucuggaggcc cucucgggga gcugguccaa      900

ugguccgacc ugauuaccag ccucuaccug cuuggacacg acaucagaau uuccgccucu      960

cuggcugaac ucaaagagau caugaagaaa guugugggca accggagcgg cugucccacg     1020

gugggggauc gcauugucga acugaucuau aucgacauug ugggacuugc ccaguucaag     1080

aaaacacugg gcccuuccug gguucacuac cagugcaugc ucagagugcu ggauagcuuu     1140

gggaccgagc ccgaguucaa ucaugccaac uaugcucagu cuaagggaca caagacaccg     1200

uggggcaaau ggaaccugaa uccucaacag uucuacacca uguuucccca uaccccugac     1260

aacuccuucc ucggguuugu cguggaacag caccugaaua gcucugauau ccaccauauu     1320

aacgagauca agcggcaaaa ucagagccuu guuuauggaa aaguggacuc cuucuggaag     1380

aacaaaaaga uuuaccugga uaucauccac acauauaugg aaguccaugc gacgguguac     1440

ggcucuagca ccaagaauau ucccuccuac gucaaaaacc acggcauccu cagcgggaga     1500

gaccugcagu uucugcuucg cgagacaaag cuguucgugg gacugggcuu ucccuaugaa     1560

gggccugccc cgcuggaggc uauugccaau ggaugugccu uccucaaccc caaauuuaau     1620

ccucccaagu cuuccaaaaa caccgauuuc uuuaucggca agccuacacu gcgggaacuu     1680

accagccagc aucccuacgc ugagguuuuc auugggagac cgcacgugug gacggucgac     1740

cugaauaacc aagaggaagu ggaggaugcc guuaaggcga uccucaauca gaaaauugaa     1800

ccuuauaugc ccuacgaguu uacaugcgag ggcaugcugc agcgcaucaa cgcuuucauc     1860

gaaaagcagg acuucuguca cggacaagug auguggccuc cccugucugc ccuucagguc     1920

aaacucgccg agccuggcca guccugcaaa cagguguguc aagaaagcca gcugauuugc     1980

gagcccuccu uuuuccagca ucugaacaaa gacaaggaua ugcucaaaua uaaggugacc     2040

ugccagucua gcgaacuggc uaaggacauc cuuguuccgu ccuuugaucc uaaaaauaag     2100

cacugugucu uccaagggga ccugcuccug uuuucuugcg ccggagcuca uccccggcac     2160

cagagagugu gucccugccg cgauuucauu aaaggccagg uggcccugug uaaggacugc     2220

cuuuga                                                                2226


<210>  1791
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__I6QTG3

<400>  1791

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  1792
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__EAX11770

<400>  1792
auggccggga ccgugcgcac cgcgugcuug gugguggcga ugcugcucag cuuggacuuc       60

ccgggacagg cgcagccccc gccgccgccg ccggacgcca ccugucacca aguccgcucc      120

uucuuccaga gacugcagcc cggacucaag ugggugccag aaacucccgu gccaggauca      180

gauuugcaag uaugucuccc uaagggccca acaugcugcu caagaaagau ggaagaaaaa      240

uaccaacuaa cagcacgauu gaacauggaa cagcugcuuc agucugcaag uauggagcuc      300

aaguucuuaa uuauucagaa ugcugcgguu uuccaagagg ccuuugaaau uguuguucgc      360

caugccaaga acuacaccaa ugccauguuc aagaacaacu acccaagccu gacuccacaa      420

gcuuuugagu uuguggguga auuuuucaca gaugugucuc ucuacaucuu ggguucugac      480

aucaauguag augacauggu caaugaauug uuugacagcc uguuuccagu caucuauacc      540

cagcuaauga acccaggccu gccugauuca gccuuggaca ucaaugagug ccuccgagga      600

gcaagacgug accugaaagu auuugggaau uuccccaagc uuauuaugac ccagguuucc      660

aagucacugc aagucacuag gaucuuccuu caggcucuga aucuuggaau ugaagugauc      720

aacacaacug aucaccugaa guucaguaag gacuguggcc gaaugcucac cagaaugugg      780

uacugcucuu acugccaggg acugaugaug guuaaacccu guggcgguua cugcaaugug      840

gucaugcaag gcuguauggc agguguggug gagauugaca aguacuggag agaauacauu      900

cugucccuug aagaacuugu gaauggcaug uacagaaucu augacaugga gaacguacug      960

cuuggucucu uuucaacaau ccaugauucu auccaguaug uccagaagaa ugcaggaaag     1020

cugaccacca cuauuggcaa guuaugugcc cauucucaac aacgccaaua uagaucugcu     1080

uauuauccug aagaucucuu uauugacaag aaaguauuaa aaguugcuca uguagaacau     1140

gaagaaaccu uauccagccg aagaagggaa cuaauucaga aguugaaguc uuucaucagc     1200

uucuauagug cuuugccugg cuacaucugc agccauagcc cuguggcgga aaacgacacc     1260

cuuugcugga auggacaaga acucguggag agauacagcc aaaaggcagc aaggaaugga     1320

augaaaaacc aguucaaucu ccaugagcug aaaaugaagg gcccugagcc aguggucagu     1380

caaauuauug acaaacugaa gcacauuaac cagcuccuga gaaccauguc uaugcccaaa     1440

gguagaguuc uggauaaaaa ccuggaugag gaaggguuug aaaguggaga cugcggugau     1500

gaugaagaug agugcauugg aggcucuggu gauggaauga uaaaagugaa gaaucagcuc     1560

cgcuuccuug cagaacuggc cuaugaucug gauguggaug augcgccugg aaacagucag     1620

caggcaacuc cgaaggacaa cgagauaagc accuuucaca accucgggaa cguucauucc     1680

ccgcugaagc uucucaccag cauggccauc ucgguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1793
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPC3__Homo_sapiens__EAX11770

<400>  1793
auggccggca ccgugcgcac cgccugccug gucguggcga ugcuccugag ccuggacuuc       60

cccgggcagg cccagccgcc cccgccgccg cccgacgcca cgugccacca ggugcggucc      120

uucuuccagc gccuccagcc cggccugaag uggguccccg agacccccgu gcccgggagc      180

gaccuccagg ugugccugcc caagggcccg accugcugcu cccggaagau ggaggagaag      240

uaccagcuga ccgcccgccu gaacauggag cagcuccugc agagcgccuc cauggagcug      300

aaguuccuca ucauccagaa cgcggccguc uuccaggagg ccuucgagau cguggugcgg      360

cacgccaaga acuacacgaa cgcgauguuc aagaacaacu accccagccu gacgccccag      420

gccuucgagu ucgucgggga guucuucacc gacguguccc uguacauccu cggcagcgac      480

aucaacgugg acgacauggu caacgagcug uucgacuccc uguuccccgu gaucuacacc      540

cagcucauga accccggccu gccggacagc gcccuggaca ucaacgagug ccuccgcggg      600

gcccggcgcg accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggucucc      660

aagagccucc aggugacccg gaucuuccug caggcccuga accucgggau cgaggugauc      720

aacaccaccg accaccugaa guucuccaag gacugcggcc gcaugcugac gcggaugugg      780

uacugcagcu acugccaggg gcucaugaug gucaagcccu gcggcggcua cugcaacgug      840

gugaugcagg ggugcauggc gggcgucgug gagaucgaca aguacuggcg cgaguacauc      900

cugucccugg aggagcucgu gaacgggaug uaccggaucu acgacaugga gaacguccug      960

cugggccucu ucagcaccau ccacgacucc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca cgaucgggaa gcugugcgcc cacagccagc agcgccagua ccgguccgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuga agguggccca cguggagcac     1140

gaggagaccc ugagcagccg ccggcgcgag cucauccaga agcugaaguc cuucaucagc     1200

uucuacuccg cgcugcccgg cuacaucugc agccacuccc ccgucgccga gaacgacacc     1260

cucugcugga acgggcagga gcugguggag cgguacagcc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu gcacgagcuc aagaugaagg ggcccgagcc cguggucucc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcugc ggaccaugag caugccgaag     1440

ggccgcgugc ucgacaagaa ccuggacgag gagggcuucg aguccgggga cugcggcgac     1500

gacgaggacg agugcaucgg gggcagcggg gacggcauga ucaaggugaa gaaccagcug     1560

cgcuuccucg ccgagcuggc guacgaccug gacgucgacg acgcccccgg caacucccag     1620

caggccacgc ccaaggacaa cgagaucagc accuuccaca accucgggaa cgugcacagc     1680

ccccugaagc ugcucaccuc cauggccauc uccguggucu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1794
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPC3__Homo_sapiens__EAX11770

<400>  1794
auggccggca ccguccgcac cgccugccuc gucgucgcca ugcuccucuc ccucgacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca gguccgcucc      120

uucuuccagc gccuccagcc cggccucaag uggguccccg agacccccgu ccccggcucc      180

gaccuccagg ucugccuccc caagggcccc accugcugcu cccgcaagau ggaggagaag      240

uaccagcuca ccgcccgccu caacauggag cagcuccucc aguccgccuc cauggagcuc      300

aaguuccuca ucauccagaa cgccgccguc uuccaggagg ccuucgagau cgucguccgc      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccucccu caccccccag      420

gccuucgagu ucgucggcga guucuucacc gacgucuccc ucuacauccu cggcuccgac      480

aucaacgucg acgacauggu caacgagcuc uucgacuccc ucuuccccgu caucuacacc      540

cagcucauga accccggccu ccccgacucc gcccucgaca ucaacgagug ccuccgcggc      600

gcccgccgcg accucaaggu cuucggcaac uuccccaagc ucaucaugac ccaggucucc      660

aagucccucc aggucacccg caucuuccuc caggcccuca accucggcau cgaggucauc      720

aacaccaccg accaccucaa guucuccaag gacugcggcc gcaugcucac ccgcaugugg      780

uacugcuccu acugccaggg ccucaugaug gucaagcccu gcggcggcua cugcaacguc      840

gucaugcagg gcugcauggc cggcgucguc gagaucgaca aguacuggcg cgaguacauc      900

cucucccucg aggagcucgu caacggcaug uaccgcaucu acgacaugga gaacguccuc      960

cucggccucu ucuccaccau ccacgacucc auccaguacg uccagaagaa cgccggcaag     1020

cucaccacca ccaucggcaa gcucugcgcc cacucccagc agcgccagua ccgcuccgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuca aggucgccca cgucgagcac     1140

gaggagaccc ucuccucccg ccgccgcgag cucauccaga agcucaaguc cuucaucucc     1200

uucuacuccg cccuccccgg cuacaucugc ucccacuccc ccgucgccga gaacgacacc     1260

cucugcugga acggccagga gcucgucgag cgcuacuccc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu ccacgagcuc aagaugaagg gccccgagcc cgucgucucc     1380

cagaucaucg acaagcucaa gcacaucaac cagcuccucc gcaccauguc caugcccaag     1440

ggccgcgucc ucgacaagaa ccucgacgag gagggcuucg aguccggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcuccggc gacggcauga ucaaggucaa gaaccagcuc     1560

cgcuuccucg ccgagcucgc cuacgaccuc gacgucgacg acgcccccgg caacucccag     1620

caggccaccc ccaaggacaa cgagaucucc accuuccaca accucggcaa cguccacucc     1680

ccccucaagc uccucaccuc cauggccauc uccgucgucu gcuucuucuu ccucguccac     1740

uga                                                                   1743


<210>  1795
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPC3__Homo_sapiens__EAX11770

<400>  1795
auggccggca ccgugagaac agcuugccug gucguugcaa ugcuccuuag ccuggacuuc       60

cccgggcagg cccaaccucc accgcccccu ccagaugcga cuugucacca ggugaggucc      120

uuuuuccagc gguugcagcc cggauuaaag uggguaccug agacgccagu gcccgguucu      180

gaccugcaag ucugccuacc uaaaggccca accuguugcu cacgcaagau ggaagagaaa      240

uaccagcuca cagcucgacu gaacauggaa cagcuucugc agagugccag cauggaguug      300

aaguuucuca ucauucaaaa ugcagccgug uuccaggaag cauuugagau aguugugcgu      360

caugcuaaaa acuauacuaa ugccauguuc aagaacaauu acccgucccu gacaccccag      420

gcuuuugagu ucgucgggga auuuuucacc gaugugucuc uguauauccu cggaucggac      480

auuaacguag augacauggu uaaugaguua uuugauucac uguucccugu gaucuacacc      540

cagcuuauga acccaggcuu gcccgacagc gcccuggaua uuaaugaaug ucuaagaggu      600

gcgaggcggg accucaaggu cuuugggaac uucccuaaac ugaucaugac ucaagugagu      660

aagucccuuc aggugacacg cauauuccug caggcauuga aucucggaau cgaggucauu      720

aacaccacgg aucaccugaa auuuucuaag gacugcggca gaauguuaac uaggaugugg      780

uauuguagcu acugccaagg ccugaugaug guuaaaccau gugggggaua uugcaaugug      840

guaaugcagg guuguauggc cggcgugguc gagaucgaua aguacuggcg ggaauacauu      900

cucucccuug aggaacuggu gaacgggaug uaucgcaucu acgacaugga gaauguuuug      960

cuaggacugu ucucaaccau acaugacagu auucaguaug ugcagaagaa cgcuggcaaa     1020

cucacaacua ccaucgguaa gcugugcgcc cacagccaac agcgacagua cagaucugca     1080

uauuaccccg aagaucuuuu uauugacaaa aagguccuga aaguggcuca uguagagcac     1140

gaggaaacau uguccucaag gcggcgugag cucauccaga agcugaaaag uuucaucagc     1200

uuuuauucug ccuuaccggg guacauuugc ucccacagcc cuguugcgga aaacgauacc     1260

cuguguugga auggacaaga gcuaguggaa cgcuacucgc agaaggccgc aagaaacggc     1320

augaagaauc aguucaaccu ccaugagcug aaaaugaagg gccccgagcc agucgugucu     1380

cagauaaucg acaaacuuaa gcacauuaau caauugcuga ggacgauguc caugccuaaa     1440

gggcgggucc ucgauaagaa ccuggacgaa gagggauuug aaucagguga uugcggcgac     1500

gaugaggacg aauguaucgg gggaaguggc gaugguauga uaaaggugaa aaaucagcuu     1560

cgauuccugg cugaguuggc cuaugaccuc gacguugaug acgcucccgg gaacagccag     1620

caggccacuc caaaggauaa ugagauuucc acauuucaua accugggcaa ugugcacucu     1680

cccuuaaaac ugcuaaccag cauggcaauc ucaguagucu gcuucuuuuu ccucgugcac     1740

uga                                                                   1743


<210>  1796
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPC3__Homo_sapiens__EAX11770

<400>  1796
auggccggca ccgugagaac cgccugccug gugguggcca ugcugcugag ccuggacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca ggugagaagc      120

uucuuccaga gacugcagcc cggccugaag ugggugcccg agacccccgu gcccggcagc      180

gaccugcagg ugugccugcc caagggcccc accugcugca gcagaaagau ggaggagaag      240

uaccagcuga ccgccagacu gaacauggag cagcugcugc agagcgccag cauggagcug      300

aaguuccuga ucauccagaa cgccgccgug uuccaggagg ccuucgagau cguggugaga      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccagccu gaccccccag      420

gccuucgagu ucgugggcga guucuucacc gacgugagcc uguacauccu gggcagcgac      480

aucaacgugg acgacauggu gaacgagcug uucgacagcc uguuccccgu gaucuacacc      540

cagcugauga accccggccu gcccgacagc gcccuggaca ucaacgagug ccugagaggc      600

gccagaagag accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggugagc      660

aagagccugc aggugaccag aaucuuccug caggcccuga accugggcau cgaggugauc      720

aacaccaccg accaccugaa guucagcaag gacugcggca gaaugcugac cagaaugugg      780

uacugcagcu acugccaggg ccugaugaug gugaagcccu gcggcggcua cugcaacgug      840

gugaugcagg gcugcauggc cggcguggug gagaucgaca aguacuggag agaguacauc      900

cugagccugg aggagcuggu gaacggcaug uacagaaucu acgacaugga gaacgugcug      960

cugggccugu ucagcaccau ccacgacagc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca ccaucggcaa gcugugcgcc cacagccagc agagacagua cagaagcgcc     1080

uacuaccccg aggaccuguu caucgacaag aaggugcuga agguggccca cguggagcac     1140

gaggagaccc ugagcagcag aagaagagag cugauccaga agcugaagag cuucaucagc     1200

uucuacagcg cccugcccgg cuacaucugc agccacagcc ccguggccga gaacgacacc     1260

cugugcugga acggccagga gcugguggag agauacagcc agaaggccgc cagaaacggc     1320

augaagaacc aguucaaccu gcacgagcug aagaugaagg gccccgagcc cguggugagc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcuga gaaccaugag caugcccaag     1440

ggcagagugc uggacaagaa ccuggacgag gagggcuucg agagcggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcagcggc gacggcauga ucaaggugaa gaaccagcug     1560

agauuccugg ccgagcuggc cuacgaccug gacguggacg acgcccccgg caacagccag     1620

caggccaccc ccaaggacaa cgagaucagc accuuccaca accugggcaa cgugcacagc     1680

ccccugaagc ugcugaccag cauggccauc agcguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1797
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPC3__Homo_sapiens__EAX11770

<400>  1797
auggccggca ccgugagaac agcuugccug gucguugcca ugcuccugag ccuugacuuc       60

cccgggcagg cgcaaccucc gcccccuccc ccugaugcua cgugucacca ggugcggucc      120

uuuuuccagc gccugcagcc cggacucaag ugggugccug agaccccggu ccccggcucu      180

gaccugcaag ugugccuucc uaaagggccc acauguugca gcagaaagau ggaagagaaa      240

uaccagcuga ccgcccggcu caacauggaa cagcugcugc aguccgccuc uauggagcuc      300

aaguuucuga ucauucaaaa ugcugccguu uuccaggagg cuuuugaaau cgugguccgc      360

caugccaaaa acuauacaaa ugcgauguuc aagaacaauu acccuagccu uacaccccag      420

gccuuugagu ucgugggaga auuuuucacc gauguuuccc uguauauucu cggcucugac      480

aucaacgugg augacauggu caaugagcug uuugauagcc uuuucccggu gauuuacacc      540

cagcugauga acccugggcu ccccgacucc gcucuggaua ucaaugaaug ucugagagga      600

gcccggcgcg accucaaggu guuuggcaac uucccuaaac ugaucaugac gcaagucagc      660

aagucucuuc agguuaccag aauuuuccug caggcucuca aucugggcau cgaggugauu      720

aacacaaccg aucaccuuaa auuuuccaag gacugcgggc ggaugcugac acgcaugugg      780

uauuguagcu acugccaagg acucaugaug gugaaacccu guggcgggua uugcaauguc      840

gugaugcagg gauguauggc cggcguugug gagaucgaua aguacuggag agaauacauu      900

cugucucugg aggaacucgu caacgggaug uaucggaucu acgacaugga gaaugugcug      960

cuuggacugu ucuccaccau ucaugacagc auccaguaug uucagaagaa cgcgggcaaa     1020

cucacgacaa ccaucggcaa gcugugcgcc cacucucaac agcgccagua cagauccgcu     1080

uauuaccccg aagaucuuuu uauugacaaa aaggugcuga aagucgccca uguggagcac     1140

gaggaaacac ucagcucccg gcgcagagag cugauccaga agcugaaauc uuucauuagc     1200

uuuuauuccg cucucccugg guacaucugc agccacucuc cggucgccga aaacgauacc     1260

cuguguugga auggacaaga gcuuguggaa cgguacuccc agaaggccgc uagaaacggc     1320

augaagaauc aguucaaccu gcaugagcuc aaaaugaagg ggcccgagcc uguugugagc     1380

cagauuaucg acaaacugaa gcacaucaau caacugcuuc gcaccauguc uaugcccaaa     1440

ggacgggucc ucgauaagaa ccuggacgaa gagggcuuug aaagcgggga uugcggagac     1500

gaugaggacg aauguauugg cggcuccggg gauggaauga ucaaggugaa aaaucagcug     1560

agauuccucg cggagcuggc cuaugaccuu gacguugaug acgcuccugg caacucucag     1620

caggccacac ccaaggauaa ugagauuagc acguuucaua accuggggaa ugugcacucc     1680

ccgcucaaac ugcugaccag cauggccauc ucugucgugu gcuucuuuuu ccuugugcac     1740

uga                                                                   1743


<210>  1798
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__P51654

<400>  1798

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  1799
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__AAA93471

<400>  1799
auggccggga ccgugcgcac cgcgugcuug gugguggcga ugcugcucag cuuggacuuc       60

ccgggacagg cgcagccccc gccgccgccg ccggacgcca ccugucacca aguccgcucc      120

uucuuccaga gacugcagcc cggacucaag ugggugccag aaacucccgu gccaggauca      180

gauuugcaag uaugucuccc uaagggccca acaugcugcu caagaaagau ggaagaaaaa      240

uaccaacuaa cagcucgauu gaacauggaa cagcugcuuc agucugcaag uauggagcuc      300

aaguucuuaa uuauucagaa ugcugcgguu uuccaagagg ccuuugaaau uguuguucgc      360

caugccaaga acuacaccaa ugccauguuc aagaacaacu acccaagccu gacuccacaa      420

gcuuuugagu uuguggguga auuuuucaca gaugugucuc ucuacaucuu ggguucugac      480

aucaauguag augacauggu caaugaauug uuugacagcc uguuuccagu caucuauacc      540

cagcuaauga acccaggccu gccugauuca gccuuggaca ucaaugagug ccuccgagga      600

gcaagacgug accugaaagu auuugggaau uuccccaagc uuauuaugac ccagguuucc      660

aagucacugc aagucacuag gaucuuccuu caggcucuga aucuuggaau ugaagugauc      720

aacacaacug aucaccugaa guucaguaag gacuguggcc gaaugcucac cagaaugugg      780

uacugcucuu acugccaggg acugaugaug guuaaacccu guggcgguua cugcaaugug      840

gucaugcaag gcuguauggc agguguggug gagauugaca aguacuggag agaauacauu      900

cugucccuug aagaacuugu gaauggcaug uacagaaucu augacaugga gaacguacug      960

cuuggucucu uuucaacaau ccaugauucu auccaguaug uccagaagaa ugcaggaaag     1020

cugaccacca cuauuggcaa guuaugugcc cauucucaac aacgccaaua uagaucugcu     1080

uauuauccug aagaucucuu uauugacaag aaaguauuaa aaguugcuca uguagaacau     1140

gaagaaaccu uauccagccg aagaagggaa cuaauucaga aguugaaguc uuucaucagc     1200

uucuauagug cuuugccugg cuacaucugc agccauagcc cuguggcgga aaacgacacc     1260

cuuugcugga auggacaaga acucguggag agauacagcc aaaaggcagc aaggaaugga     1320

augaaaaacc aguucaaucu ccaugagcug aaaaugaagg gcccugagcc aguggucagu     1380

caaauuauug acaaacugaa gcacauuaac cagcuccuga gaaccauguc uaugcccaaa     1440

gguagaguuc uggauaaaaa ccuggaugag gaaggguuug aaaguggaga cugcggugau     1500

gaugaagaug agugcauugg agggucuggu gauggaauga uaaaagugaa gaaucagcuc     1560

cgcuuccuug cagaacuggc cuaugaucug gauguggaug augcgccugg aaacagucag     1620

caggcaacuc cgaaggacaa cgagauaagc accuuucaca accucgggaa cguucauucc     1680

ccgcugaagc uucucaccag cauggccauc ucgguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1800
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPC3__Homo_sapiens__AAA93471

<400>  1800
auggccggca ccgugcgcac cgccugccug gucguggcga ugcuccugag ccuggacuuc       60

cccgggcagg cccagccgcc cccgccgccg cccgacgcca cgugccacca ggugcggucc      120

uucuuccagc gccuccagcc cggccugaag uggguccccg agacccccgu gcccgggagc      180

gaccuccagg ugugccugcc caagggcccg accugcugcu cccggaagau ggaggagaag      240

uaccagcuga ccgcccgccu gaacauggag cagcuccugc agagcgccuc cauggagcug      300

aaguuccuca ucauccagaa cgcggccguc uuccaggagg ccuucgagau cguggugcgg      360

cacgccaaga acuacacgaa cgcgauguuc aagaacaacu accccagccu gacgccccag      420

gccuucgagu ucgucgggga guucuucacc gacguguccc uguacauccu cggcagcgac      480

aucaacgugg acgacauggu caacgagcug uucgacuccc uguuccccgu gaucuacacc      540

cagcucauga accccggccu gccggacagc gcccuggaca ucaacgagug ccuccgcggg      600

gcccggcgcg accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggucucc      660

aagagccucc aggugacccg gaucuuccug caggcccuga accucgggau cgaggugauc      720

aacaccaccg accaccugaa guucuccaag gacugcggcc gcaugcugac gcggaugugg      780

uacugcagcu acugccaggg gcucaugaug gucaagcccu gcggcggcua cugcaacgug      840

gugaugcagg ggugcauggc gggcgucgug gagaucgaca aguacuggcg cgaguacauc      900

cugucccugg aggagcucgu gaacgggaug uaccggaucu acgacaugga gaacguccug      960

cugggccucu ucagcaccau ccacgacucc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca cgaucgggaa gcugugcgcc cacagccagc agcgccagua ccgguccgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuga agguggccca cguggagcac     1140

gaggagaccc ugagcagccg ccggcgcgag cucauccaga agcugaaguc cuucaucagc     1200

uucuacuccg cgcugcccgg cuacaucugc agccacuccc ccgucgccga gaacgacacc     1260

cucugcugga acgggcagga gcugguggag cgguacagcc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu gcacgagcuc aagaugaagg ggcccgagcc cguggucucc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcugc ggaccaugag caugccgaag     1440

ggccgcgugc ucgacaagaa ccuggacgag gagggcuucg aguccgggga cugcggcgac     1500

gacgaggacg agugcaucgg gggcagcggg gacggcauga ucaaggugaa gaaccagcug     1560

cgcuuccucg ccgagcuggc guacgaccug gacgucgacg acgcccccgg caacucccag     1620

caggccacgc ccaaggacaa cgagaucagc accuuccaca accucgggaa cgugcacagc     1680

ccccugaagc ugcucaccuc cauggccauc uccguggucu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1801
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPC3__Homo_sapiens__AAA93471

<400>  1801
auggccggca ccguccgcac cgccugccuc gucgucgcca ugcuccucuc ccucgacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca gguccgcucc      120

uucuuccagc gccuccagcc cggccucaag uggguccccg agacccccgu ccccggcucc      180

gaccuccagg ucugccuccc caagggcccc accugcugcu cccgcaagau ggaggagaag      240

uaccagcuca ccgcccgccu caacauggag cagcuccucc aguccgccuc cauggagcuc      300

aaguuccuca ucauccagaa cgccgccguc uuccaggagg ccuucgagau cgucguccgc      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccucccu caccccccag      420

gccuucgagu ucgucggcga guucuucacc gacgucuccc ucuacauccu cggcuccgac      480

aucaacgucg acgacauggu caacgagcuc uucgacuccc ucuuccccgu caucuacacc      540

cagcucauga accccggccu ccccgacucc gcccucgaca ucaacgagug ccuccgcggc      600

gcccgccgcg accucaaggu cuucggcaac uuccccaagc ucaucaugac ccaggucucc      660

aagucccucc aggucacccg caucuuccuc caggcccuca accucggcau cgaggucauc      720

aacaccaccg accaccucaa guucuccaag gacugcggcc gcaugcucac ccgcaugugg      780

uacugcuccu acugccaggg ccucaugaug gucaagcccu gcggcggcua cugcaacguc      840

gucaugcagg gcugcauggc cggcgucguc gagaucgaca aguacuggcg cgaguacauc      900

cucucccucg aggagcucgu caacggcaug uaccgcaucu acgacaugga gaacguccuc      960

cucggccucu ucuccaccau ccacgacucc auccaguacg uccagaagaa cgccggcaag     1020

cucaccacca ccaucggcaa gcucugcgcc cacucccagc agcgccagua ccgcuccgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuca aggucgccca cgucgagcac     1140

gaggagaccc ucuccucccg ccgccgcgag cucauccaga agcucaaguc cuucaucucc     1200

uucuacuccg cccuccccgg cuacaucugc ucccacuccc ccgucgccga gaacgacacc     1260

cucugcugga acggccagga gcucgucgag cgcuacuccc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu ccacgagcuc aagaugaagg gccccgagcc cgucgucucc     1380

cagaucaucg acaagcucaa gcacaucaac cagcuccucc gcaccauguc caugcccaag     1440

ggccgcgucc ucgacaagaa ccucgacgag gagggcuucg aguccggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcuccggc gacggcauga ucaaggucaa gaaccagcuc     1560

cgcuuccucg ccgagcucgc cuacgaccuc gacgucgacg acgcccccgg caacucccag     1620

caggccaccc ccaaggacaa cgagaucucc accuuccaca accucggcaa cguccacucc     1680

ccccucaagc uccucaccuc cauggccauc uccgucgucu gcuucuucuu ccucguccac     1740

uga                                                                   1743


<210>  1802
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPC3__Homo_sapiens__AAA93471

<400>  1802
auggccggca ccgugagaac agcuugccug gucguugcaa ugcuccuuag ccuggacuuc       60

cccgggcagg cccaaccucc accgcccccu ccagaugcga cuugucacca ggugaggucc      120

uuuuuccagc gguugcagcc cggauuaaag uggguaccug agacgccagu gcccgguucu      180

gaccugcaag ucugccuacc uaaaggccca accuguugcu cacgcaagau ggaagagaaa      240

uaccagcuca cagcucgacu gaacauggaa cagcuucugc agagugccag cauggaguug      300

aaguuucuca ucauucaaaa ugcagccgug uuccaggaag cauuugagau aguugugcgu      360

caugcuaaaa acuauacuaa ugccauguuc aagaacaauu acccgucccu gacaccccag      420

gcuuuugagu ucgucgggga auuuuucacc gaugugucuc uguauauccu cggaucggac      480

auuaacguag augacauggu uaaugaguua uuugauucac uguucccugu gaucuacacc      540

cagcuuauga acccaggcuu gcccgacagc gcccuggaua uuaaugaaug ucuaagaggu      600

gcgaggcggg accucaaggu cuuugggaac uucccuaaac ugaucaugac ucaagugagu      660

aagucccuuc aggugacacg cauauuccug caggcauuga aucucggaau cgaggucauu      720

aacaccacgg aucaccugaa auuuucuaag gacugcggca gaauguuaac uaggaugugg      780

uauuguagcu acugccaagg ccugaugaug guuaaaccau gugggggaua uugcaaugug      840

guaaugcagg guuguauggc cggcgugguc gagaucgaua aguacuggcg ggaauacauu      900

cucucccuug aggaacuggu gaacgggaug uaucgcaucu acgacaugga gaauguuuug      960

cuaggacugu ucucaaccau acaugacagu auucaguaug ugcagaagaa cgcuggcaaa     1020

cucacaacua ccaucgguaa gcugugcgcc cacagccaac agcgacagua cagaucugca     1080

uauuaccccg aagaucuuuu uauugacaaa aagguccuga aaguggcuca uguagagcac     1140

gaggaaacau uguccucaag gcggcgugag cucauccaga agcugaaaag uuucaucagc     1200

uuuuauucug ccuuaccggg guacauuugc ucccacagcc cuguugcgga aaacgauacc     1260

cuguguugga auggacaaga gcuaguggaa cgcuacucgc agaaggccgc aagaaacggc     1320

augaagaauc aguucaaccu ccaugagcug aaaaugaagg gccccgagcc agucgugucu     1380

cagauaaucg acaaacuuaa gcacauuaau caauugcuga ggacgauguc caugccuaaa     1440

gggcgggucc ucgauaagaa ccuggacgaa gagggauuug aaucagguga uugcggcgac     1500

gaugaggacg aauguaucgg gggaaguggc gaugguauga uaaaggugaa aaaucagcuu     1560

cgauuccugg cugaguuggc cuaugaccuc gacguugaug acgcucccgg gaacagccag     1620

caggccacuc caaaggauaa ugagauuucc acauuucaua accugggcaa ugugcacucu     1680

cccuuaaaac ugcuaaccag cauggcaauc ucaguagucu gcuucuuuuu ccucgugcac     1740

uga                                                                   1743


<210>  1803
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPC3__Homo_sapiens__AAA93471

<400>  1803
auggccggca ccgugagaac cgccugccug gugguggcca ugcugcugag ccuggacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca ggugagaagc      120

uucuuccaga gacugcagcc cggccugaag ugggugcccg agacccccgu gcccggcagc      180

gaccugcagg ugugccugcc caagggcccc accugcugca gcagaaagau ggaggagaag      240

uaccagcuga ccgccagacu gaacauggag cagcugcugc agagcgccag cauggagcug      300

aaguuccuga ucauccagaa cgccgccgug uuccaggagg ccuucgagau cguggugaga      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccagccu gaccccccag      420

gccuucgagu ucgugggcga guucuucacc gacgugagcc uguacauccu gggcagcgac      480

aucaacgugg acgacauggu gaacgagcug uucgacagcc uguuccccgu gaucuacacc      540

cagcugauga accccggccu gcccgacagc gcccuggaca ucaacgagug ccugagaggc      600

gccagaagag accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggugagc      660

aagagccugc aggugaccag aaucuuccug caggcccuga accugggcau cgaggugauc      720

aacaccaccg accaccugaa guucagcaag gacugcggca gaaugcugac cagaaugugg      780

uacugcagcu acugccaggg ccugaugaug gugaagcccu gcggcggcua cugcaacgug      840

gugaugcagg gcugcauggc cggcguggug gagaucgaca aguacuggag agaguacauc      900

cugagccugg aggagcuggu gaacggcaug uacagaaucu acgacaugga gaacgugcug      960

cugggccugu ucagcaccau ccacgacagc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca ccaucggcaa gcugugcgcc cacagccagc agagacagua cagaagcgcc     1080

uacuaccccg aggaccuguu caucgacaag aaggugcuga agguggccca cguggagcac     1140

gaggagaccc ugagcagcag aagaagagag cugauccaga agcugaagag cuucaucagc     1200

uucuacagcg cccugcccgg cuacaucugc agccacagcc ccguggccga gaacgacacc     1260

cugugcugga acggccagga gcugguggag agauacagcc agaaggccgc cagaaacggc     1320

augaagaacc aguucaaccu gcacgagcug aagaugaagg gccccgagcc cguggugagc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcuga gaaccaugag caugcccaag     1440

ggcagagugc uggacaagaa ccuggacgag gagggcuucg agagcggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcagcggc gacggcauga ucaaggugaa gaaccagcug     1560

agauuccugg ccgagcuggc cuacgaccug gacguggacg acgcccccgg caacagccag     1620

caggccaccc ccaaggacaa cgagaucagc accuuccaca accugggcaa cgugcacagc     1680

ccccugaagc ugcugaccag cauggccauc agcguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1804
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPC3__Homo_sapiens__AAA93471

<400>  1804
auggccggca ccgugagaac agcuugccug gucguugcca ugcuccugag ccuugacuuc       60

cccgggcagg cgcaaccucc gcccccuccc ccugaugcua cgugucacca ggugcggucc      120

uuuuuccagc gccugcagcc cggacucaag ugggugccug agaccccggu ccccggcucu      180

gaccugcaag ugugccuucc uaaagggccc acauguugca gcagaaagau ggaagagaaa      240

uaccagcuga ccgcccggcu caacauggaa cagcugcugc aguccgccuc uauggagcuc      300

aaguuucuga ucauucaaaa ugcugccguu uuccaggagg cuuuugaaau cgugguccgc      360

caugccaaaa acuauacaaa ugcgauguuc aagaacaauu acccuagccu uacaccccag      420

gccuuugagu ucgugggaga auuuuucacc gauguuuccc uguauauucu cggcucugac      480

aucaacgugg augacauggu caaugagcug uuugauagcc uuuucccggu gauuuacacc      540

cagcugauga acccugggcu ccccgacucc gcucuggaua ucaaugaaug ucugagagga      600

gcccggcgcg accucaaggu guuuggcaac uucccuaaac ugaucaugac gcaagucagc      660

aagucucuuc agguuaccag aauuuuccug caggcucuca aucugggcau cgaggugauu      720

aacacaaccg aucaccuuaa auuuuccaag gacugcgggc ggaugcugac acgcaugugg      780

uauuguagcu acugccaagg acucaugaug gugaaacccu guggcgggua uugcaauguc      840

gugaugcagg gauguauggc cggcguugug gagaucgaua aguacuggag agaauacauu      900

cugucucugg aggaacucgu caacgggaug uaucggaucu acgacaugga gaaugugcug      960

cuuggacugu ucuccaccau ucaugacagc auccaguaug uucagaagaa cgcgggcaaa     1020

cucacgacaa ccaucggcaa gcugugcgcc cacucucaac agcgccagua cagauccgcu     1080

uauuaccccg aagaucuuuu uauugacaaa aaggugcuga aagucgccca uguggagcac     1140

gaggaaacac ucagcucccg gcgcagagag cugauccaga agcugaaauc uuucauuagc     1200

uuuuauuccg cucucccugg guacaucugc agccacucuc cggucgccga aaacgauacc     1260

cuguguugga auggacaaga gcuuguggaa cgguacuccc agaaggccgc uagaaacggc     1320

augaagaauc aguucaaccu gcaugagcuc aaaaugaagg ggcccgagcc uguugugagc     1380

cagauuaucg acaaacugaa gcacaucaau caacugcuuc gcaccauguc uaugcccaaa     1440

ggacgggucc ucgauaagaa ccuggacgaa gagggcuuug aaagcgggga uugcggagac     1500

gaugaggacg aauguauugg cggcuccggg gauggaauga ucaaggugaa aaaucagcug     1560

agauuccucg cggagcuggc cuaugaccuu gacguugaug acgcuccugg caacucucag     1620

caggccacac ccaaggauaa ugagauuagc acguuucaua accuggggaa ugugcacucc     1680

ccgcucaaac ugcugaccag cauggccauc ucugucgugu gcuucuuuuu ccuugugcac     1740

uga                                                                   1743


<210>  1805
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__Q8IYG2

<400>  1805

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Phe Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  1806
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPC3__Homo_sapiens__AAH35972

<400>  1806
auggccggga ccgugcgcac cgcgugcuug gugguggcga ugcugcucag cuuggacuuc       60

ccgggacagg cgcagccccc gccgccgccg ccggacgcca ccugucacca aguccgcucc      120

uucuuccaga gacugcagcc cggacucaag ugggugccag aaacucccgu gccaggauca      180

gauuugcaag uaugucuccc uaagggccca acaugcugcu caagaaagau ggaagaaaaa      240

uaccaacuaa cagcacgauu gaacauggaa cagcugcuuc agucugcaag uauggagcuc      300

aaguucuuaa uuauucagaa ugcugcgguu uuccaagagg ccuuugaaau uguuguucgc      360

caugccaaga acuacaccaa ugccauguuc aagaacaacu acccaagccu gacuccacaa      420

gcuuuugagu uuguggguga auuuuucaca gaugugucuc ucuacaucuu ggguucugac      480

aucaauguag augacauggu caaugaauug uuugacagcc uguuuccagu caucuauacc      540

cagcuaauga acccaggccu gccugauuca gccuuggaca ucaaugagug ccuccgagga      600

gcaagacgug accugaaagu auuugggaau uuccccaagc uuauuaugac ccagguuucc      660

aagucacugc aagucacuag gaucuuccuu caggcucuga aucuuggaau ugaagugauc      720

aacacaacug aucaccugaa guucaguaag gacuguggcc gaaugcucac cagaaugugg      780

uacugcucuu acugccaggg acugaugaug guuaaacccu guggcgguua cugcaaugug      840

gucaugcaag gcuguauggc agguguggug gagauugaca aguacuggag agaauacauu      900

cugucccuug aagaacuugu gaauggcaug uacagaaucu augacaugga gaacguacug      960

cuuggucucu uuucaacaau ccaugauucu auccaguaug uccagaagaa ugcaggaaag     1020

cugaccacca cuauuggcaa guuaugugcc cauucucaac aacgccaaua uagauuugcu     1080

uauuauccug aagaucucuu uauugacaag aaaguauuaa aaguugcuca uguagaacau     1140

gaagaaaccu uauccagccg aagaagggaa cuaauucaga aguugaaguc uuucaucagc     1200

uucuauagug cuuugccugg cuacaucugc agccauagcc cuguggcgga aaacgacacc     1260

cuuugcugga auggacaaga acucguggag agauacagcc aaaaggcagc aaggaaugga     1320

augaaaaacc aguucaaucu ccaugagcug aaaaugaagg gcccugagcc aguggucagu     1380

caaauuauug acaaacugaa gcacauuaac cagcuccuga gaaccauguc uaugcccaaa     1440

gguagaguuc uggauaaaaa ccuggaugag gaaggguuug aaaguggaga cugcggugau     1500

gaugaagaug agugcauugg aggcucuggu gauggaauga uaaaagugaa gaaucagcuc     1560

cgcuuccuug cagaacuggc cuaugaucug gauguggaug augcgccugg aaacagucag     1620

caggcaacuc cgaaggacaa cgagauaagc accuuucaca accucgggaa cguucauucc     1680

ccgcugaagc uucucaccag cauggccauc ucgguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1807
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPC3__Homo_sapiens__AAH35972

<400>  1807
auggccggca ccgugcgcac cgccugccug gucguggcga ugcuccugag ccuggacuuc       60

cccgggcagg cccagccgcc cccgccgccg cccgacgcca cgugccacca ggugcggucc      120

uucuuccagc gccuccagcc cggccugaag uggguccccg agacccccgu gcccgggagc      180

gaccuccagg ugugccugcc caagggcccg accugcugcu cccggaagau ggaggagaag      240

uaccagcuga ccgcccgccu gaacauggag cagcuccugc agagcgccuc cauggagcug      300

aaguuccuca ucauccagaa cgcggccguc uuccaggagg ccuucgagau cguggugcgg      360

cacgccaaga acuacacgaa cgcgauguuc aagaacaacu accccagccu gacgccccag      420

gccuucgagu ucgucgggga guucuucacc gacguguccc uguacauccu cggcagcgac      480

aucaacgugg acgacauggu caacgagcug uucgacuccc uguuccccgu gaucuacacc      540

cagcucauga accccggccu gccggacagc gcccuggaca ucaacgagug ccuccgcggg      600

gcccggcgcg accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggucucc      660

aagagccucc aggugacccg gaucuuccug caggcccuga accucgggau cgaggugauc      720

aacaccaccg accaccugaa guucuccaag gacugcggcc gcaugcugac gcggaugugg      780

uacugcagcu acugccaggg gcucaugaug gucaagcccu gcggcggcua cugcaacgug      840

gugaugcagg ggugcauggc gggcgucgug gagaucgaca aguacuggcg cgaguacauc      900

cugucccugg aggagcucgu gaacgggaug uaccggaucu acgacaugga gaacguccug      960

cugggccucu ucagcaccau ccacgacucc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca cgaucgggaa gcugugcgcc cacagccagc agcgccagua ccgguucgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuga agguggccca cguggagcac     1140

gaggagaccc uguccagccg ccggcgcgag cucauccaga agcucaagag cuucaucucc     1200

uucuacagcg cgcugcccgg cuacaucugc ucccacagcc ccgucgccga gaacgacacc     1260

cugugcugga acgggcagga gcugguggag cgguacuccc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu gcacgagcuc aagaugaagg ggcccgagcc cguggucagc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcugc ggaccauguc caugccgaag     1440

ggccgcgugc ucgacaagaa ccuggacgag gagggcuucg agagcgggga cugcggcgac     1500

gacgaggacg agugcaucgg gggcuccggg gacggcauga ucaaggugaa gaaccagcug     1560

cgcuuccucg ccgagcuggc guacgaccug gacgucgacg acgcccccgg caacagccag     1620

caggccacgc ccaaggacaa cgagaucucc accuuccaca accucgggaa cgugcacagc     1680

ccccugaagc ugcucaccuc cauggccauc agcguggucu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1808
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPC3__Homo_sapiens__AAH35972

<400>  1808
auggccggca ccguccgcac cgccugccuc gucgucgcca ugcuccucuc ccucgacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca gguccgcucc      120

uucuuccagc gccuccagcc cggccucaag uggguccccg agacccccgu ccccggcucc      180

gaccuccagg ucugccuccc caagggcccc accugcugcu cccgcaagau ggaggagaag      240

uaccagcuca ccgcccgccu caacauggag cagcuccucc aguccgccuc cauggagcuc      300

aaguuccuca ucauccagaa cgccgccguc uuccaggagg ccuucgagau cgucguccgc      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccucccu caccccccag      420

gccuucgagu ucgucggcga guucuucacc gacgucuccc ucuacauccu cggcuccgac      480

aucaacgucg acgacauggu caacgagcuc uucgacuccc ucuuccccgu caucuacacc      540

cagcucauga accccggccu ccccgacucc gcccucgaca ucaacgagug ccuccgcggc      600

gcccgccgcg accucaaggu cuucggcaac uuccccaagc ucaucaugac ccaggucucc      660

aagucccucc aggucacccg caucuuccuc caggcccuca accucggcau cgaggucauc      720

aacaccaccg accaccucaa guucuccaag gacugcggcc gcaugcucac ccgcaugugg      780

uacugcuccu acugccaggg ccucaugaug gucaagcccu gcggcggcua cugcaacguc      840

gucaugcagg gcugcauggc cggcgucguc gagaucgaca aguacuggcg cgaguacauc      900

cucucccucg aggagcucgu caacggcaug uaccgcaucu acgacaugga gaacguccuc      960

cucggccucu ucuccaccau ccacgacucc auccaguacg uccagaagaa cgccggcaag     1020

cucaccacca ccaucggcaa gcucugcgcc cacucccagc agcgccagua ccgcuucgcc     1080

uacuaccccg aggaccucuu caucgacaag aagguccuca aggucgccca cgucgagcac     1140

gaggagaccc ucuccucccg ccgccgcgag cucauccaga agcucaaguc cuucaucucc     1200

uucuacuccg cccuccccgg cuacaucugc ucccacuccc ccgucgccga gaacgacacc     1260

cucugcugga acggccagga gcucgucgag cgcuacuccc agaaggccgc ccgcaacggc     1320

augaagaacc aguucaaccu ccacgagcuc aagaugaagg gccccgagcc cgucgucucc     1380

cagaucaucg acaagcucaa gcacaucaac cagcuccucc gcaccauguc caugcccaag     1440

ggccgcgucc ucgacaagaa ccucgacgag gagggcuucg aguccggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcuccggc gacggcauga ucaaggucaa gaaccagcuc     1560

cgcuuccucg ccgagcucgc cuacgaccuc gacgucgacg acgcccccgg caacucccag     1620

caggccaccc ccaaggacaa cgagaucucc accuuccaca accucggcaa cguccacucc     1680

ccccucaagc uccucaccuc cauggccauc uccgucgucu gcuucuucuu ccucguccac     1740

uga                                                                   1743


<210>  1809
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPC3__Homo_sapiens__AAH35972

<400>  1809
auggccggca ccgugagaac agcuugccug gucguugcaa ugcuccuuag ccuggacuuc       60

cccgggcagg cccaaccucc accgcccccu ccagaugcga cuugucacca ggugaggucc      120

uuuuuccagc gguugcagcc cggauuaaag uggguaccug agacgccagu gcccgguucu      180

gaccugcaag ucugccuacc uaaaggccca accuguugcu cacgcaagau ggaagagaaa      240

uaccagcuca cagcucgacu gaacauggaa cagcuucugc agagugccag cauggaguug      300

aaguuucuca ucauucaaaa ugcagccgug uuccaggaag cauuugagau aguugugcgu      360

caugcuaaaa acuauacuaa ugccauguuc aagaacaauu acccgucccu gacaccccag      420

gcuuuugagu ucgucgggga auuuuucacc gaugugucuc uguauauccu cggaucggac      480

auuaacguag augacauggu uaaugaguua uuugauucac uguucccugu gaucuacacc      540

cagcuuauga acccaggcuu gcccgacagc gcccuggaua uuaaugaaug ucuaagaggu      600

gcgaggcggg accucaaggu cuuugggaac uucccuaaac ugaucaugac ucaagugagu      660

aagucccuuc aggugacacg cauauuccug caggcauuga aucucggaau cgaggucauu      720

aacaccacgg aucaccugaa auuuucuaag gacugcggca gaauguuaac uaggaugugg      780

uauuguagcu acugccaagg ccugaugaug guuaaaccau gugggggaua uugcaaugug      840

guaaugcagg guuguauggc cggcgugguc gagaucgaua aguacuggcg ggaauacauu      900

cucucccuug aggaacuggu gaacgggaug uaucgcaucu acgacaugga gaauguuuug      960

cuaggacugu ucucaaccau acaugacagu auucaguaug ugcagaagaa cgcuggcaaa     1020

cucacaacua ccaucgguaa gcugugcgcc cacagccaac agcgacagua cagauuugca     1080

uauuaccccg aagaucuuuu cauugacaaa aagguccuga aaguggcuca uguagagcac     1140

gaggaaacau ugucuuccag gcggcgugag cucauccaga agcugaaauc auuuaucagc     1200

uucuauagug ccuuaccggg guacauuugc ucucacuccc cuguugcgga aaacgauacc     1260

cuguguugga auggacaaga gcuaguggaa cgcuacagcc agaaggccgc aagaaacggc     1320

augaagaauc aguuuaaccu ccaugagcug aaaaugaagg gccccgagcc agucgugucg     1380

cagauaaucg acaaacuuaa gcacauuaau caauugcuga ggacgauguc uaugccuaaa     1440

gggcgggucc ucgauaagaa ccuggacgaa gagggauucg aauccgguga uugcggcgac     1500

gaugaggacg aauguaucgg gggaucaggc gaugguauga uaaaggugaa aaaucagcuu     1560

cgauuucugg cugaguuggc cuaugaccuc gacguugaug acgcucccgg gaacagucag     1620

caggccacuc caaaggauaa ugagauuagc acauuccaua accugggcaa ugugcacucc     1680

cccuuaaaac ugcuaaccuc uauggcaauc agcguagucu gcuuuuucuu ucucgugcac     1740

uga                                                                   1743


<210>  1810
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPC3__Homo_sapiens__AAH35972

<400>  1810
auggccggca ccgugagaac cgccugccug gugguggcca ugcugcugag ccuggacuuc       60

cccggccagg cccagccccc cccccccccc cccgacgcca ccugccacca ggugagaagc      120

uucuuccaga gacugcagcc cggccugaag ugggugcccg agacccccgu gcccggcagc      180

gaccugcagg ugugccugcc caagggcccc accugcugca gcagaaagau ggaggagaag      240

uaccagcuga ccgccagacu gaacauggag cagcugcugc agagcgccag cauggagcug      300

aaguuccuga ucauccagaa cgccgccgug uuccaggagg ccuucgagau cguggugaga      360

cacgccaaga acuacaccaa cgccauguuc aagaacaacu accccagccu gaccccccag      420

gccuucgagu ucgugggcga guucuucacc gacgugagcc uguacauccu gggcagcgac      480

aucaacgugg acgacauggu gaacgagcug uucgacagcc uguuccccgu gaucuacacc      540

cagcugauga accccggccu gcccgacagc gcccuggaca ucaacgagug ccugagaggc      600

gccagaagag accugaaggu guucggcaac uuccccaagc ugaucaugac ccaggugagc      660

aagagccugc aggugaccag aaucuuccug caggcccuga accugggcau cgaggugauc      720

aacaccaccg accaccugaa guucagcaag gacugcggca gaaugcugac cagaaugugg      780

uacugcagcu acugccaggg ccugaugaug gugaagcccu gcggcggcua cugcaacgug      840

gugaugcagg gcugcauggc cggcguggug gagaucgaca aguacuggag agaguacauc      900

cugagccugg aggagcuggu gaacggcaug uacagaaucu acgacaugga gaacgugcug      960

cugggccugu ucagcaccau ccacgacagc auccaguacg ugcagaagaa cgccggcaag     1020

cugaccacca ccaucggcaa gcugugcgcc cacagccagc agagacagua cagauucgcc     1080

uacuaccccg aggaccuguu caucgacaag aaggugcuga agguggccca cguggagcac     1140

gaggagaccc ugagcagcag aagaagagag cugauccaga agcugaagag cuucaucagc     1200

uucuacagcg cccugcccgg cuacaucugc agccacagcc ccguggccga gaacgacacc     1260

cugugcugga acggccagga gcugguggag agauacagcc agaaggccgc cagaaacggc     1320

augaagaacc aguucaaccu gcacgagcug aagaugaagg gccccgagcc cguggugagc     1380

cagaucaucg acaagcugaa gcacaucaac cagcugcuga gaaccaugag caugcccaag     1440

ggcagagugc uggacaagaa ccuggacgag gagggcuucg agagcggcga cugcggcgac     1500

gacgaggacg agugcaucgg cggcagcggc gacggcauga ucaaggugaa gaaccagcug     1560

agauuccugg ccgagcuggc cuacgaccug gacguggacg acgcccccgg caacagccag     1620

caggccaccc ccaaggacaa cgagaucagc accuuccaca accugggcaa cgugcacagc     1680

ccccugaagc ugcugaccag cauggccauc agcguggugu gcuucuucuu ccuggugcac     1740

uga                                                                   1743


<210>  1811
<211>  1743
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPC3__Homo_sapiens__AAH35972

<400>  1811
auggccggca ccgugagaac agcuugccug gucguugcca ugcuccugag ccuugacuuc       60

cccgggcagg cgcaaccucc gcccccuccc ccugaugcua cgugucacca ggugcggucc      120

uuuuuccagc gccugcagcc cggacucaag ugggugccug agaccccggu ccccggcucu      180

gaccugcaag ugugccuucc uaaagggccc acauguugca gcagaaagau ggaagagaaa      240

uaccagcuga ccgcccggcu caacauggaa cagcugcugc aguccgccuc uauggagcuc      300

aaguuucuga ucauucaaaa ugcugccguu uuccaggagg cuuuugaaau cgugguccgc      360

caugccaaaa acuauacaaa ugcgauguuc aagaacaauu acccuagccu uacaccccag      420

gccuuugagu ucgugggaga auuuuucacc gauguuuccc uguauauucu cggcucugac      480

aucaacgugg augacauggu caaugagcug uuugauagcc uuuucccggu gauuuacacc      540

cagcugauga acccugggcu ccccgacucc gcucuggaua ucaaugaaug ucugagagga      600

gcccggcgcg accucaaggu guuuggcaac uucccuaaac ugaucaugac gcaagucagc      660

aagucucuuc agguuaccag aauuuuccug caggcucuca aucugggcau cgaggugauu      720

aacacaaccg aucaccuuaa auuuuccaag gacugcgggc ggaugcugac acgcaugugg      780

uauuguagcu acugccaagg acucaugaug gugaaacccu guggcgggua uugcaauguc      840

gugaugcagg gauguauggc cggcguugug gagaucgaua aguacuggag agaauacauu      900

cugucucugg aggaacucgu caacgggaug uaucggaucu acgacaugga gaaugugcug      960

cuuggacugu ucuccaccau ucaugacagc auccaguaug uucagaagaa cgcgggcaaa     1020

cucacgacaa ccaucggcaa gcugugcgcc cacucucaac agcgccagua cagauuugcu     1080

uauuaccccg aagaucuuuu cauugacaaa aaggugcuga aagucgccca uguggagcac     1140

gaggaaacac ucuccagccg gcgcagagag cugauccaga agcugaaauc cuuuauuucu     1200

uucuauagcg cucucccugg guacaucugc ucccacagcc cggucgccga aaacgauacc     1260

cuguguugga auggacaaga gcuuguggaa cgguacucuc agaaggccgc uagaaacggc     1320

augaagaauc aguuuaaccu gcaugagcuc aaaaugaagg ggcccgagcc uguugugucc     1380

cagauuaucg acaaacugaa gcacaucaau caacugcuuc gcaccaugag caugcccaaa     1440

ggacgggucc ucgauaagaa ccuggacgaa gagggcuucg aaucugggga uugcggagac     1500

gaugaggacg aauguauugg cggcagcggg gauggaauga ucaaggugaa aaaucagcug     1560

agauuucucg cggagcuggc cuaugaccuu gacguugaug acgcuccugg caacucccag     1620

caggccacac ccaaggauaa ugagauuucu acguuccaua accuggggaa ugugcacagc     1680

ccgcucaaac ugcugaccuc cauggccauc agcgucgugu gcuuuuucuu ucuugugcac     1740

uga                                                                   1743


<210>  1812
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__A0A024RA55

<400>  1812

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Gly Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile 
            340                 345                 350         


Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr 
        355                 360                 365             


Ile Thr Ile Val Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr 
    370                 375                 380                 


Asp Val Leu Met Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe 
385                 390                 395                 400 


Val Val Thr Cys Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile 
                405                 410                 415     


Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val 
            420                 425                 430         


Asp Val Asp Glu Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly 
        435                 440                 445             


Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu 
    450                 455                 460                 


Ala Leu Thr Ser Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser 
465                 470                 475                 480 


Pro Leu Arg Met Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala 
                485                 490                 495     


Ile Phe Val Thr Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu 
            500                 505                 510         


Tyr Asn Pro Ile Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly 
        515                 520                 525             


Leu Ser Val Phe Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn 
    530                 535                 540                 


Gln Glu Lys Asp Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
545                 550                 555                 560 






<210>  1813
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__EAW93784

<400>  1813
auggaauguc ucuacuauuu ccugggauuu cugcuccugg cugcaagauu gccacuugau       60

gccgccaaac gauuucauga ugugcugggc aaugaaagac cuucugcuua caugagggag      120

cacaaucaau uaaauggcug gucuucugau gaaaaugacu ggaaugaaaa acucuaccca      180

guguggaagc ggggagacau gagguggaaa aacuccugga agggaggccg ugugcaggcg      240

guccugacca gugacucacc agcccucgug ggcucaaaua uaacauuugc ggugaaccug      300

auauucccua gaugccaaaa ggaagaugcc aauggcaaca uagucuauga gaagaacugc      360

agaaaugagg cugguuuauc ugcugauccg uauguuuaca acuggacagc auggucagag      420

gacagugacg gggaaaaugg caccggccaa agccaucaua acgucuuccc ugaugggaaa      480

ccuuuuccuc accaccccgg auggagaaga uggaauuuca ucuacgucuu ccacacacuu      540

ggucaguauu uccagaaauu gggacgaugu ucagugagag uuucugugaa cacagccaau      600

gugacacuug ggccucaacu cauggaagug acugucuaca gaagacaugg acgggcauau      660

guucccaucg cacaagugaa agauguguac gugguaacag aucagauucc uguguuugug      720

acuauguucc agaagaacga ucgaaauuca uccgacgaaa ccuuccucaa agaucucccc      780

auuauguuug auguccugau ucaugauccu agccacuucc ucaauuauuc uaccauuaac      840

uacaagugga gcuucgggga uaauacuggc cuguuuguuu ccaccaauca uacugugaau      900

cacacguaug ugcucaaugg aaccuucagc cuuaaccuca cugugaaagc ugcagcacca      960

ggaccuuguc cgccaccgcc accaccaccc agaccuucaa aacccacccc uucuuuagga     1020

ccugcuggug acaacccccu ggagcugagu aggauuccug augaaaacug ccagauuaac     1080

agauauggcc acuuucaagc caccaucaca auuguagagg gaaucuuaga gguuaacauc     1140

auccagauga cagacguccu gaugccggug ccauggccug aaagcucccu aauagacuuu     1200

gucgugaccu gccaagggag cauucccacg gaggucugua ccaucauuuc ugaccccacc     1260

ugcgagauca cccagaacac agucugcagc ccuguggaug uggaugagau gugucugcug     1320

acugugagac gaaccuucaa ugggucuggg acguacugug ugaaccucac ccugggggau     1380

gacacaagcc uggcucucac gagcacccug auuucuguuc cugacagaga cccagccucg     1440

ccuuuaagga uggcaaacag ugcccugauc uccguuggcu gcuuggccau auuugucacu     1500

gugaucuccc ucuuggugua caaaaaacac aaggaauaca acccaauaga aaauaguccu     1560

gggaaugugg ucagaagcaa aggccugagu gucuuucuca accgugcaaa agccguguuc     1620

uucccgggaa accaggaaaa ggauccgcua cucaaaaacc aagaauuuaa aggaguuucu     1680

uaa                                                                   1683


<210>  1814
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPNMB/m__Homo_sapiens__EAW93784

<400>  1814
auggagugcc uguacuacuu ccucggcuuc cugcugcucg ccgcccgccu gccccuggac       60

gcggccaagc gguuccacga cgugcucggg aacgagcgcc cgagcgccua caugcgggag      120

cacaaccagc ugaacggcug guccagcgac gagaacgacu ggaacgagaa gcuguacccc      180

gucuggaagc gcggggacau gcgguggaag aacuccugga agggcgggcg cgugcaggcc      240

gugcucacca gcgacucccc cgcccugguc ggcagcaaca ucaccuucgc ggugaaccug      300

aucuuccccc ggugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

cgcaacgagg ccgggcucuc cgccgacccg uacgucuaca acuggacggc guggagcgag      420

gacuccgacg gcgagaacgg gaccggccag agccaccaca acguguuccc cgacgggaag      480

cccuuccccc accacccggg cuggcggcgc uggaacuuca ucuacguguu ccacacccug      540

ggccaguacu uccagaagcu ggggcggugc uccguccgcg ugagcgugaa caccgccaac      600

gucacgcucg gcccccagcu gauggaggug accguguacc ggcgccacgg gcgggccuac      660

guccccaucg cccaggugaa ggacguguac gucgugaccg accagauccc cguguucguc      720

accauguucc agaagaacga ccgcaacucc agcgacgaga cguuccugaa ggaccucccg      780

aucauguucg acgugcugau ccacgacccc ucccacuucc ugaacuacag caccaucaac      840

uacaaguggu ccuucggcga caacaccggc cucuucguga gcaccaacca cacggucaac      900

cacaccuacg ugcugaacgg gaccuucucc cugaaccuca ccgucaaggc cgcggccccc      960

ggccccugcc cgcccccgcc gcccccgccc cggcccagca agcccacgcc cagccugggg     1020

cccgccggcg acaacccccu ggagcucucc cgcauccccg acgagaacug ccagaucaac     1080

cgguacgggc acuuccaggc caccaucacc aucguggagg gcauccugga ggugaacauc     1140

auccagauga ccgacguccu gaugcccgug cccuggccgg agagcucccu caucgacuuc     1200

guggucacgu gccagggcag cauccccacc gaggugugca ccaucaucuc cgacccgacc     1260

ugcgagauca cgcagaacac cgugugcagc cccgucgacg uggacgagau gugccugcug     1320

accgugcgcc ggaccuucaa cggguccggc acguacugcg ucaaccucac ccugggggac     1380

gacaccagcc uggcccucac cuccacgcug aucagcgugc ccgaccgcga ccccgcgagc     1440

ccccugcgca uggccaacuc cgcccucauc uccgugggcu gccuggccau cuucgucacc     1500

gugaucagcc ugcucgugua caagaagcac aaggaguaca accccaucga gaacuccccg     1560

gggaacgucg ugcggagcaa gggccugucc guguuccuga accgcgccaa ggcggucuuc     1620

uuccccggca accaggagaa ggacccccuc cugaagaacc aggaguucaa gggggugagc     1680

uga                                                                   1683


<210>  1815
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPNMB/m__Homo_sapiens__EAW93784

<400>  1815
auggagugcc ucuacuacuu ccucggcuuc cuccuccucg ccgcccgccu cccccucgac       60

gccgccaagc gcuuccacga cguccucggc aacgagcgcc ccuccgccua caugcgcgag      120

cacaaccagc ucaacggcug guccuccgac gagaacgacu ggaacgagaa gcucuacccc      180

gucuggaagc gcggcgacau gcgcuggaag aacuccugga agggcggccg cguccaggcc      240

guccucaccu ccgacucccc cgcccucguc ggcuccaaca ucaccuucgc cgucaaccuc      300

aucuuccccc gcugccagaa ggaggacgcc aacggcaaca ucgucuacga gaagaacugc      360

cgcaacgagg ccggccucuc cgccgacccc uacgucuaca acuggaccgc cugguccgag      420

gacuccgacg gcgagaacgg caccggccag ucccaccaca acgucuuccc cgacggcaag      480

cccuuccccc accaccccgg cuggcgccgc uggaacuuca ucuacgucuu ccacacccuc      540

ggccaguacu uccagaagcu cggccgcugc uccguccgcg ucuccgucaa caccgccaac      600

gucacccucg gcccccagcu cauggagguc accgucuacc gccgccacgg ccgcgccuac      660

guccccaucg cccaggucaa ggacgucuac gucgucaccg accagauccc cgucuucguc      720

accauguucc agaagaacga ccgcaacucc uccgacgaga ccuuccucaa ggaccucccc      780

aucauguucg acguccucau ccacgacccc ucccacuucc ucaacuacuc caccaucaac      840

uacaaguggu ccuucggcga caacaccggc cucuucgucu ccaccaacca caccgucaac      900

cacaccuacg uccucaacgg caccuucucc cucaaccuca ccgucaaggc cgccgccccc      960

ggccccugcc cccccccccc cccccccccc cgccccucca agcccacccc cucccucggc     1020

cccgccggcg acaacccccu cgagcucucc cgcauccccg acgagaacug ccagaucaac     1080

cgcuacggcc acuuccaggc caccaucacc aucgucgagg gcauccucga ggucaacauc     1140

auccagauga ccgacguccu caugcccguc cccuggcccg aguccucccu caucgacuuc     1200

gucgucaccu gccagggcuc cauccccacc gaggucugca ccaucaucuc cgaccccacc     1260

ugcgagauca cccagaacac cgucugcucc cccgucgacg ucgacgagau gugccuccuc     1320

accguccgcc gcaccuucaa cggcuccggc accuacugcg ucaaccucac ccucggcgac     1380

gacaccuccc ucgcccucac cuccacccuc aucuccgucc ccgaccgcga ccccgccucc     1440

ccccuccgca uggccaacuc cgcccucauc uccgucggcu gccucgccau cuucgucacc     1500

gucaucuccc uccucgucua caagaagcac aaggaguaca accccaucga gaacuccccc     1560

ggcaacgucg uccgcuccaa gggccucucc gucuuccuca accgcgccaa ggccgucuuc     1620

uuccccggca accaggagaa ggacccccuc cucaagaacc aggaguucaa gggcgucucc     1680

uga                                                                   1683


<210>  1816
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPNMB/m__Homo_sapiens__EAW93784

<400>  1816
auggagugcc uauacuauuu ccucggcuuu cuucuguugg ccgcuagauu accccuggac       60

gcagccaaga gguuccacga ugugcuaggg aacgaacggc cuagcgcgua caugcgcgag      120

cauaaucagc ucaacggaug guccucugac gaaaaugauu ggaacgagaa acuguaucca      180

gucuggaagc gaggugacau gcguuggaaa aauucaugga agggcgggag aguucaagcu      240

gugcuuacca gugauagccc ggcccuggua ggauccaaca ucacauuugc agugaauuug      300

auuuucccca ggugucagaa agaagacgcc aacggcaaua uagucuacga gaagaacugc      360

cggaaugagg cuggucucuc ugcagauccu uauguguaca acuggacugc cuggucggaa      420

gacucagaug gggagaaugg aacgggccag agccaccaua acguuuuucc agacggcaag      480

cccuucccuc accauccagg guggcgcaga uggaauuuua ucuauguguu ccacacccug      540

ggacaguacu uucaaaaacu ggguaggugu aguguccggg uguccguaaa cacagcuaac      600

guuacucucg gcccccaguu aauggaagug accgucuacc gccgacacgg gagagccuau      660

gugccuauug cgcaagugaa ggaugucuac guugugacag accagauccc aguauucgug      720

accauguuuc agaaaaauga uaggaacucu agcgacgaga cuuuccugaa ggaccuuccg      780

auuauguuug augucuugau ccaugacccc ucccacuucc ugaauuauuc aacaauaaac      840

uacaaaugga guuucggaga uaauaccggc cuauuuguga gcacgaacca uacuguuaau      900

cacaccuaug ugcucaacgg uacauucucu cugaaucuua cugucaaggc agccgcuccu      960

gggccauguc ccccuccacc cccgccuccc cggccaucca agccuacccc cucacuggga     1020

ccagccggcg acaaccccuu ggagcucagc cguaucccug augaaaauug ccagauuaac     1080

cgcuacggcc acuuucaggc aacaaucacc auuguggagg ggauccugga aguaaauaua     1140

auucagauga cggacguuuu aaugccagug ccguggcccg agaguucucu gaucgauuuc     1200

gucgugacuu gccaaggauc cauuccuaca gaagucugua ccaucaucag cgacccaacu     1260

ugcgagauua cacagaacac cguguguucg cccguugaug uggacgagau gugccuccuu     1320

acgguaagaa ggaccuuuaa ugguucuggc acauauugug ucaaccugac uuugggggau     1380

gacaccuccc uagcucugac aucaacucuc auaagugugc cugaccggga uccagccagc     1440

ccccugcgaa uggcgaacuc cgcccuuauc ucuguuggau gccuggcaau uuucgugacc     1500

gucaucagcu ugcucgugua caaaaagcau aaagaauaca auccgauaga gaacucaccu     1560

ggcaauguag ugcgcaguaa gggucugucc gucuuuuuaa acagagcuaa agccguuuuc     1620

uuuccaggga aucaggaaaa ggacccccug cugaaaaacc aagaguucaa gggcgugagc     1680

uga                                                                   1683


<210>  1817
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPNMB/m__Homo_sapiens__EAW93784

<400>  1817
auggagugcc uguacuacuu ccugggcuuc cugcugcugg ccgccagacu gccccuggac       60

gccgccaaga gauuccacga cgugcugggc aacgagagac ccagcgccua caugagagag      120

cacaaccagc ugaacggcug gagcagcgac gagaacgacu ggaacgagaa gcuguacccc      180

guguggaaga gaggcgacau gagauggaag aacagcugga agggcggcag agugcaggcc      240

gugcugacca gcgacagccc cgcccuggug ggcagcaaca ucaccuucgc cgugaaccug      300

aucuucccca gaugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

agaaacgagg ccggccugag cgccgacccc uacguguaca acuggaccgc cuggagcgag      420

gacagcgacg gcgagaacgg caccggccag agccaccaca acguguuccc cgacggcaag      480

cccuuccccc accaccccgg cuggagaaga uggaacuuca ucuacguguu ccacacccug      540

ggccaguacu uccagaagcu gggcagaugc agcgugagag ugagcgugaa caccgccaac      600

gugacccugg gcccccagcu gauggaggug accguguaca gaagacacgg cagagccuac      660

gugcccaucg cccaggugaa ggacguguac guggugaccg accagauccc cguguucgug      720

accauguucc agaagaacga cagaaacagc agcgacgaga ccuuccugaa ggaccugccc      780

aucauguucg acgugcugau ccacgacccc agccacuucc ugaacuacag caccaucaac      840

uacaagugga gcuucggcga caacaccggc cuguucguga gcaccaacca caccgugaac      900

cacaccuacg ugcugaacgg caccuucagc cugaaccuga ccgugaaggc cgccgccccc      960

ggccccugcc cccccccccc cccccccccc agacccagca agcccacccc cagccugggc     1020

cccgccggcg acaacccccu ggagcugagc agaauccccg acgagaacug ccagaucaac     1080

agauacggcc acuuccaggc caccaucacc aucguggagg gcauccugga ggugaacauc     1140

auccagauga ccgacgugcu gaugcccgug cccuggcccg agagcagccu gaucgacuuc     1200

guggugaccu gccagggcag cauccccacc gaggugugca ccaucaucag cgaccccacc     1260

ugcgagauca cccagaacac cgugugcagc cccguggacg uggacgagau gugccugcug     1320

accgugagaa gaaccuucaa cggcagcggc accuacugcg ugaaccugac ccugggcgac     1380

gacaccagcc uggcccugac cagcacccug aucagcgugc ccgacagaga ccccgccagc     1440

ccccugagaa uggccaacag cgcccugauc agcgugggcu gccuggccau cuucgugacc     1500

gugaucagcc ugcuggugua caagaagcac aaggaguaca accccaucga gaacagcccc     1560

ggcaacgugg ugagaagcaa gggccugagc guguuccuga acagagccaa ggccguguuc     1620

uuccccggca accaggagaa ggacccccug cugaagaacc aggaguucaa gggcgugagc     1680

uga                                                                   1683


<210>  1818
<211>  1683
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPNMB/m__Homo_sapiens__EAW93784

<400>  1818
auggagugcc uguacuauuu ccucggcuuu cugcuucugg ccgcuagacu cccccuggac       60

gccgcgaagc gguuccacga ugugcuuggg aacgaacgcc cuagcgcuua caugagagag      120

cauaaucagc ugaacggaug guccucugac gaaaaugauu ggaacgagaa acucuauccg      180

gucuggaagc ggggcgacau gcgcuggaaa aauagcugga aagggggaag aguucaagcc      240

gugcugaccu ccgauucucc cgcccuggug ggcagcaaca ucacauuugc ugucaaucuc      300

auuuucccuc ggugucagaa agaagacgcc aacgggaaua ucguguacga gaagaacugc      360

cgcaaugagg cuggacuguc cgccgauccc uauguuuaca acuggacggc guggucugaa      420

gacagcgaug gcgagaaugg caccgggcag ucccaccaua acguguuucc ugacggaaag      480

cccuucccuc accauccggg cuggagacgg uggaauuuua uuuaugucuu ccacacacuu      540

gggcaguacu uucaaaaacu gggacgcugu agcgugagag uuucugugaa caccgccaac      600

gucacacucg gcccccagcu gauggaagug accguguacc ggcgccacgg gagagcuuau      660

gucccuaucg cccagguuaa ggauguguac guggucacag accagauucc cguguucguu      720

accauguuuc aaaagaauga ucggaacucc agcgacgaga cguuccuuaa ggaccugccu      780

aucauguuug augugcucau ccaugacccc ucucacuucc ugaauuauuc caccauuaac      840

uacaaaugga gcuucggaga uaauacaggc cuguuugucu cuaccaacca uacagugaau      900

cacaccuaug uucucaacgg cacguucucc cugaaucuua cagugaaggc ugccgcgccg      960

gggccuuguc ccccuccccc ucccccgccc cgcccuagca agcccacccc uucccuggga     1020

cccgccggcg acaacccgcu cgagcugucu agaaucccug augaaaauug ccagauuaac     1080

cgguacgggc acuuucaggc uacaaucacc auugucgagg gaauccuuga agugaauauu     1140

auccagauga ccgacguccu gaugcccgug ccuuggcccg agagcucccu caucgauuuc     1200

guugugacau gccaaggcag cauuccuacg gaagucugua ccaucauuuc ugaccccaca     1260

ugcgagauca cccagaacac aguguguucc ccgguugaug uggacgagau gugccugcug     1320

accgucagac gcacguuuaa ugggagcgga acauauugug ugaaccucac ccugggcgau     1380

gacaccucuc uugcccugac aagcacccuc auuuccgugc cugaccggga ucccgcuucu     1440

ccccugagaa uggccaacag cgcccuuauc uccguuggcu gccuggcuau cuucgucaca     1500

gugauuagcc uccuggugua caaaaagcau aaagaauaca auccuaucga gaacucuccg     1560

gggaaugucg ugcgcuccaa gggacugagc guuuuucuca accgggcgaa agccguguuc     1620

uuucccggca aucaggaaaa ggacccucug cuuaaaaacc aagaguucaa gggggucucu     1680

uga                                                                   1683


<210>  1819
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__Q14956

<400>  1819

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  1820
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__AAH32783

<400>  1820
auggaauguc ucuacuauuu ccugggauuu cugcuccugg cugcaagauu gccacuugau       60

gccgccaaac gauuucauga ugugcugggc aaugaaagac cuucugcuua caugagggag      120

cacaaucaau uaaauggcug gucuucugau gaaaaugacu ggaaugaaaa acucuaccca      180

guguggaagc ggggagacau gagguggaaa aacuccugga agggaggccg ugugcaggcg      240

guccugacca gugacucacc agcccucgug ggcucaaaua uaacauuugc ggugaaccug      300

auauucccua gaugccaaaa ggaagaugcc aauggcaaca uagucuauga gaagaacugc      360

agaaaugagg cugguuuauc ugcugauccg uauguuuaca acuggacagc auggucagag      420

gacagugacg gggaaaaugg caccggccaa agccaucaua acgucuuccc ugaugggaaa      480

ccuuuuccuc accaccccgg auggagaaga uggaauuuca ucuacgucuu ccacacacuu      540

ggucaguauu uccagaaauu gggacgaugu ucagugagag uuucugugaa cacagccaau      600

gugacacuug ggccucaacu cauggaagug acugucuaca gaagacaugg acgggcauau      660

guucccaucg cacaagugaa agauguguac gugguaacag aucagauucc uguguuugug      720

acuauguucc agaagaacga ucgaaauuca uccgacgaaa ccuuccucaa agaucucccc      780

auuauguuug auguccugau ucaugauccu agccacuucc ucaauuauuc uaccauuaac      840

uacaagugga gcuucgggga uaauacuggc cuguuuguuu ccaccaauca uacugugaau      900

cacacguaug ugcucaaugg aaccuucagc cuuaaccuca cugugaaagc ugcagcacca      960

ggaccuuguc cgccaccgcc accaccaccc agaccuucaa aacccacccc uucuuuagca     1020

acuacucuaa aaucuuauga uucaaacacc ccaggaccug cuggugacaa cccccuggag     1080

cugaguagga uuccugauga aaacugccag auuaacagau auggccacuu ucaagccacc     1140

aucacaauug uagagggaau cuuagagguu aacaucaucc agaugacaga cguccugaug     1200

ccggugccau ggccugaaag cucccuaaua gacuuugucg ugaccugcca agggagcauu     1260

cccacggagg ucuguaccau cauuucugac cccaccugcg agaucaccca gaacacaguc     1320

ugcagcccug uggaugugga ugagaugugu cugcugacug ugagacgaac cuucaauggg     1380

ucugggacgu acugugugaa ccucacccug ggggaugaca caagccuggc ucucacgagc     1440

acccugauuu cuguuccuga cagagaccca gccucgccuu uaaggauggc aaacagcgcc     1500

cugaucuccg uuggcugcuu ggccauauuu gucacuguga ucucccucuu gguguacaaa     1560

aaacacaagg aauacaaccc aauagaaaau aguccuggga auguggucag aagcaaaggc     1620

cugagugucu uucucaaccg ugcaaaagcc guguucuucc cgggaaacca ggaaaaggau     1680

ccgcuacuca aaaaccaaga auuuaaagga guuucuuaa                            1719


<210>  1821
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPNMB/m__Homo_sapiens__AAH32783

<400>  1821
auggagugcc uguacuacuu ccucggcuuc cugcugcucg ccgcccgccu gccccuggac       60

gcggccaagc gguuccacga cgugcucggg aacgagcgcc cgagcgccua caugcgggag      120

cacaaccagc ugaacggcug guccagcgac gagaacgacu ggaacgagaa gcuguacccc      180

gucuggaagc gcggggacau gcgguggaag aacuccugga agggcgggcg cgugcaggcc      240

gugcucacca gcgacucccc cgcccugguc ggcagcaaca ucaccuucgc ggugaaccug      300

aucuuccccc ggugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

cgcaacgagg ccgggcucuc cgccgacccg uacgucuaca acuggacggc guggagcgag      420

gacuccgacg gcgagaacgg gaccggccag agccaccaca acguguuccc cgacgggaag      480

cccuuccccc accacccggg cuggcggcgc uggaacuuca ucuacguguu ccacacccug      540

ggccaguacu uccagaagcu ggggcggugc uccguccgcg ugagcgugaa caccgccaac      600

gucacgcucg gcccccagcu gauggaggug accguguacc ggcgccacgg gcgggccuac      660

guccccaucg cccaggugaa ggacguguac gucgugaccg accagauccc cguguucguc      720

accauguucc agaagaacga ccgcaacucc agcgacgaga cguuccugaa ggaccucccg      780

aucauguucg acgugcugau ccacgacccc ucccacuucc ugaacuacag caccaucaac      840

uacaaguggu ccuucggcga caacaccggc cucuucguga gcaccaacca cacggucaac      900

cacaccuacg ugcugaacgg gaccuucucc cugaaccuca ccgucaaggc cgcggccccc      960

ggccccugcc cgcccccgcc gcccccgccc cggcccagca agcccacgcc cagccuggcc     1020

accacccuga aguccuacga cagcaacacc cccgggcccg ccggcgacaa cccccucgag     1080

cugucccgca uccccgacga gaacugccag aucaaccggu acgggcacuu ccaggccacg     1140

aucaccaucg uggagggcau ccuggaggug aacaucaucc agaugaccga cguccucaug     1200

cccgugccgu ggcccgagag cucccugauc gacuucgugg ugaccugcca gggcagcauc     1260

cccacggagg ucugcaccau caucuccgac ccgaccugcg agaucaccca gaacacggug     1320

ugcagccccg ucgacgugga cgagaugugc cugcucaccg ugcgccggac cuucaacggg     1380

uccggcaccu acugcgucaa ccugacgcug ggggacgaca ccagccucgc gcugaccucc     1440

acccugauca gcgugcccga ccgcgacccc gccagccccc uccgcauggc caacuccgcc     1500

cugaucuccg ugggcugccu ggccaucuuc gucacgguga ucagccuccu gguguacaag     1560

aagcacaagg aguacaaccc gaucgagaac ucccccggga acgucgugcg gagcaagggc     1620

cuguccgugu uccucaaccg cgcgaaggcc gucuucuucc ccggcaacca ggagaaggac     1680

ccccugcuga agaaccagga guucaagggg gugagcuga                            1719


<210>  1822
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPNMB/m__Homo_sapiens__AAH32783

<400>  1822
auggagugcc ucuacuacuu ccucggcuuc cuccuccucg ccgcccgccu cccccucgac       60

gccgccaagc gcuuccacga cguccucggc aacgagcgcc ccuccgccua caugcgcgag      120

cacaaccagc ucaacggcug guccuccgac gagaacgacu ggaacgagaa gcucuacccc      180

gucuggaagc gcggcgacau gcgcuggaag aacuccugga agggcggccg cguccaggcc      240

guccucaccu ccgacucccc cgcccucguc ggcuccaaca ucaccuucgc cgucaaccuc      300

aucuuccccc gcugccagaa ggaggacgcc aacggcaaca ucgucuacga gaagaacugc      360

cgcaacgagg ccggccucuc cgccgacccc uacgucuaca acuggaccgc cugguccgag      420

gacuccgacg gcgagaacgg caccggccag ucccaccaca acgucuuccc cgacggcaag      480

cccuuccccc accaccccgg cuggcgccgc uggaacuuca ucuacgucuu ccacacccuc      540

ggccaguacu uccagaagcu cggccgcugc uccguccgcg ucuccgucaa caccgccaac      600

gucacccucg gcccccagcu cauggagguc accgucuacc gccgccacgg ccgcgccuac      660

guccccaucg cccaggucaa ggacgucuac gucgucaccg accagauccc cgucuucguc      720

accauguucc agaagaacga ccgcaacucc uccgacgaga ccuuccucaa ggaccucccc      780

aucauguucg acguccucau ccacgacccc ucccacuucc ucaacuacuc caccaucaac      840

uacaaguggu ccuucggcga caacaccggc cucuucgucu ccaccaacca caccgucaac      900

cacaccuacg uccucaacgg caccuucucc cucaaccuca ccgucaaggc cgccgccccc      960

ggccccugcc cccccccccc cccccccccc cgccccucca agcccacccc cucccucgcc     1020

accacccuca aguccuacga cuccaacacc cccggccccg ccggcgacaa cccccucgag     1080

cucucccgca uccccgacga gaacugccag aucaaccgcu acggccacuu ccaggccacc     1140

aucaccaucg ucgagggcau ccucgagguc aacaucaucc agaugaccga cguccucaug     1200

cccguccccu ggcccgaguc cucccucauc gacuucgucg ucaccugcca gggcuccauc     1260

cccaccgagg ucugcaccau caucuccgac cccaccugcg agaucaccca gaacaccguc     1320

ugcucccccg ucgacgucga cgagaugugc cuccucaccg uccgccgcac cuucaacggc     1380

uccggcaccu acugcgucaa ccucacccuc ggcgacgaca ccucccucgc ccucaccucc     1440

acccucaucu ccguccccga ccgcgacccc gccucccccc uccgcauggc caacuccgcc     1500

cucaucuccg ucggcugccu cgccaucuuc gucaccguca ucucccuccu cgucuacaag     1560

aagcacaagg aguacaaccc caucgagaac ucccccggca acgucguccg cuccaagggc     1620

cucuccgucu uccucaaccg cgccaaggcc gucuucuucc ccggcaacca ggagaaggac     1680

ccccuccuca agaaccagga guucaagggc gucuccuga                            1719


<210>  1823
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPNMB/m__Homo_sapiens__AAH32783

<400>  1823
auggagugcc uguacuauuu ccucggcuuu cuucuguugg ccgcuagauu accccuggac       60

gcagccaaga gguuccacga ugugcuaggg aacgaacggc cuagcgcgua caugcgcgag      120

cauaaucagc ucaacggaug guccucugac gaaaaugauu ggaacgagaa acuguaucca      180

gucuggaagc gaggugacau gcguuggaaa aauucaugga agggcgggag aguucaagcu      240

gugcuuacca gugauagccc ggcccuggua ggauccaaca ucacauuugc agugaauuug      300

auuuucccca ggugucagaa agaagacgcc aacggcaaua uagucuacga gaagaacugc      360

cggaaugagg cuggucucuc ugcagauccu uauguguaca acuggacugc cuggucggaa      420

gacucagaug gggagaaugg aacgggccag agccaccaua acguuuuucc agacggcaag      480

cccuucccuc accauccagg guggcgcaga uggaauuuua ucuauguguu ccacacccug      540

ggacaguacu uucaaaaacu ggguaggugu aguguccggg uguccguaaa cacagcuaac      600

guuacucucg gcccccaguu aauggaagug accgucuacc gccgacacgg gagagccuau      660

gugccuauug cgcaagugaa ggaugucuac guugugacag accagauccc aguauucgug      720

accauguuuc agaaaaauga uaggaacucu agcgacgaga cuuuccugaa ggaccuuccg      780

auuauguuug augucuugau ccaugacccc ucccacuucc ugaauuauuc aacaauaaac      840

uacaaaugga guuucggaga uaauaccggc cuauuuguga gcacgaacca uacuguuaau      900

cacaccuaug ugcucaacgg uacauucucu cugaaucuua cugucaaggc agccgcuccu      960

gggccauguc ccccuccacc cccgccuccc cggccaucca agccuacccc cucacuggcc     1020

acaaccuuga aaagcuacga caguaacacg ccaggacccg caggcgauaa uccucucgag     1080

cugucucgua ucccagacga aaacugccag auuaaucgcu auggccacuu ucaggcuacu     1140

aucacaauug uggaggggau cuuagaagua aacauaauuc agaugaccga uguucugaug     1200

ccggugcccu ggccugaguc cagccucauc gacuucgucg ugacuugcca aggaucgauu     1260

ccaacagaag ucuguaccau caucucugau cccacgugcg agauuaccca gaauacagug     1320

uguuccccug uugacgugga ugagaugugc cuucugacug uaagaaggac cuuuaacggu     1380

ucaggcacau acugugucaa cuugacucua ggggacgaca ccagucuggc ccucacaagc     1440

acccugauau ccgugccaga ucgggacccc gcgucuccgc uucgaauggc caauagcgca     1500

cugaucucag uuggaugcuu ggcuauuuuc gugacuguca ucagucuccu gguguacaag     1560

aaacauaagg aauauaaccc uauagaaaau uccccaggca acguagugcg cagcaaaggu     1620

uuaucuguuu uucugaauag agccaaggcu gucuucuuuc ccgggaacca ggagaaagau     1680

ccucuacuca agaaucaaga guucaagggc gugucauga                            1719


<210>  1824
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPNMB/m__Homo_sapiens__AAH32783

<400>  1824
auggagugcc uguacuacuu ccugggcuuc cugcugcugg ccgccagacu gccccuggac       60

gccgccaaga gauuccacga cgugcugggc aacgagagac ccagcgccua caugagagag      120

cacaaccagc ugaacggcug gagcagcgac gagaacgacu ggaacgagaa gcuguacccc      180

guguggaaga gaggcgacau gagauggaag aacagcugga agggcggcag agugcaggcc      240

gugcugacca gcgacagccc cgcccuggug ggcagcaaca ucaccuucgc cgugaaccug      300

aucuucccca gaugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

agaaacgagg ccggccugag cgccgacccc uacguguaca acuggaccgc cuggagcgag      420

gacagcgacg gcgagaacgg caccggccag agccaccaca acguguuccc cgacggcaag      480

cccuuccccc accaccccgg cuggagaaga uggaacuuca ucuacguguu ccacacccug      540

ggccaguacu uccagaagcu gggcagaugc agcgugagag ugagcgugaa caccgccaac      600

gugacccugg gcccccagcu gauggaggug accguguaca gaagacacgg cagagccuac      660

gugcccaucg cccaggugaa ggacguguac guggugaccg accagauccc cguguucgug      720

accauguucc agaagaacga cagaaacagc agcgacgaga ccuuccugaa ggaccugccc      780

aucauguucg acgugcugau ccacgacccc agccacuucc ugaacuacag caccaucaac      840

uacaagugga gcuucggcga caacaccggc cuguucguga gcaccaacca caccgugaac      900

cacaccuacg ugcugaacgg caccuucagc cugaaccuga ccgugaaggc cgccgccccc      960

ggccccugcc cccccccccc cccccccccc agacccagca agcccacccc cagccuggcc     1020

accacccuga agagcuacga cagcaacacc cccggccccg ccggcgacaa cccccuggag     1080

cugagcagaa uccccgacga gaacugccag aucaacagau acggccacuu ccaggccacc     1140

aucaccaucg uggagggcau ccuggaggug aacaucaucc agaugaccga cgugcugaug     1200

cccgugcccu ggcccgagag cagccugauc gacuucgugg ugaccugcca gggcagcauc     1260

cccaccgagg ugugcaccau caucagcgac cccaccugcg agaucaccca gaacaccgug     1320

ugcagccccg uggacgugga cgagaugugc cugcugaccg ugagaagaac cuucaacggc     1380

agcggcaccu acugcgugaa ccugacccug ggcgacgaca ccagccuggc ccugaccagc     1440

acccugauca gcgugcccga cagagacccc gccagccccc ugagaauggc caacagcgcc     1500

cugaucagcg ugggcugccu ggccaucuuc gugaccguga ucagccugcu gguguacaag     1560

aagcacaagg aguacaaccc caucgagaac agccccggca acguggugag aagcaagggc     1620

cugagcgugu uccugaacag agccaaggcc guguucuucc ccggcaacca ggagaaggac     1680

ccccugcuga agaaccagga guucaagggc gugagcuga                            1719


<210>  1825
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPNMB/m__Homo_sapiens__AAH32783

<400>  1825
auggagugcc uguacuauuu ccucggcuuu cugcuucugg ccgcuagacu cccccuggac       60

gccgcgaagc gguuccacga ugugcuuggg aacgaacgcc cuagcgcuua caugagagag      120

cauaaucagc ugaacggaug guccucugac gaaaaugauu ggaacgagaa acucuauccg      180

gucuggaagc ggggcgacau gcgcuggaaa aauagcugga aagggggaag aguucaagcc      240

gugcugaccu ccgauucucc cgcccuggug ggcagcaaca ucacauuugc ugucaaucuc      300

auuuucccuc ggugucagaa agaagacgcc aacgggaaua ucguguacga gaagaacugc      360

cgcaaugagg cuggacuguc cgccgauccc uauguuuaca acuggacggc guggucugaa      420

gacagcgaug gcgagaaugg caccgggcag ucccaccaua acguguuucc ugacggaaag      480

cccuucccuc accauccggg cuggagacgg uggaauuuua uuuaugucuu ccacacacuu      540

gggcaguacu uucaaaaacu gggacgcugu agcgugagag uuucugugaa caccgccaac      600

gucacacucg gcccccagcu gauggaagug accguguacc ggcgccacgg gagagcuuau      660

gucccuaucg cccagguuaa ggauguguac guggucacag accagauucc cguguucguu      720

accauguuuc aaaagaauga ucggaacucc agcgacgaga cguuccuuaa ggaccugccu      780

aucauguuug augugcucau ccaugacccc ucucacuucc ugaauuauuc caccauuaac      840

uacaaaugga gcuucggaga uaauacaggc cuguuugucu cuaccaacca uacagugaau      900

cacaccuaug uucucaacgg cacguucucc cugaaucuua cagugaaggc ugccgcgccg      960

gggccuuguc ccccuccccc ucccccgccc cgcccuagca agcccacccc uucccuggcc     1020

acaacccuca aaucuuacga cagcaacacc cccggaccgg cuggcgauaa uccucuggag     1080

cuuuccagaa uccccgacga aaacugccag auuaaucggu augggcacuu ucaggccaca     1140

aucacgauug ucgagggaau ccuggaagug aacauuaucc agaugaccga uguccucaug     1200

ccugugcccu ggccugagag cucucugauc gacuucguug ugacaugcca aggcuccauu     1260

cccaccgaag ucuguacaau cauuagcgau ccgaccugcg agaucacgca gaauacagug     1320

uguucuccug uugacgugga ugagaugugc cugcucaccg ucagacgcac cuuuaacggg     1380

agcggaacau acugugugaa ccugacccuu ggcgacgaca caucccuggc ucucacgucu     1440

acccugauua gcgugcccga ucgggacccc gccuccccuc uuagaauggc caauagcgcu     1500

cugaucucug uuggcugccu cgcgaucuuc gucacaguga uuucccugcu gguguacaag     1560

aaacauaagg aauauaaccc gaucgagaau agccccggga acgucgugcg cucuaaagga     1620

cucuccguuu uucugaaucg ggccaaggcu guguucuuuc cuggcaacca ggaaaaagau     1680

ccccuucuga agaaucaaga guucaagggg gucagcuga                            1719


<210>  1826
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__Q8IXJ5

<400>  1826

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Asp Trp Leu Leu Gln Thr Pro Lys Leu Leu Leu Tyr 
            180                 185                 190         


Leu Ser Leu Lys Phe Gln Pro Ser Leu Phe Leu Leu Tyr Asn 
        195                 200                 205     


<210>  1827
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__CAD43718

<400>  1827
auggaauguc ucuacuauuu ccugggauuu cugcuccugg cugcaagauu gccacuugau       60

gccgccaaac gauuucauga ugugcugggc aaugaaagac cuucugcuua caugagggag      120

cacaaucaau uaaauggcug gucuucugau gaaaaugacu ggaaugaaaa acucuaccca      180

guguggaagc ggggagacau gagguggaaa aacuccugga agggaggccg ugugcaggcg      240

guccugacca gugacucacc agcccucgug ggcucaaaua uaacauuugc ggugaaccug      300

auauucccua gaugccaaaa ggaagaugcc aauggcaaca uagucuauga gaagaacugc      360

agaaaugagg cugguuuauc ugcugauccg uauguuuaca acuggacagc auggucagag      420

gacagugacg gggaaaaugg caccggccaa agccaucaua acgucuuccc ugaugggaaa      480

ccuuuuccuc accaccccgg auggagaaga uggaauuuca ucuacgucuu ccacacacuu      540

gauuggcuuu uacaaacccc uaagcuucuu cuuuaccuuu ccuuaaaauu ucaaccuucu      600

cuuuucuuac ucuauaauug a                                                621


<210>  1828
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPNMB/m__Homo_sapiens__CAD43718

<400>  1828
auggagugcc uguacuacuu ccucggcuuc cugcugcucg ccgcccgccu gccccuggac       60

gcggccaagc gguuccacga cgugcucggg aacgagcgcc cgagcgccua caugcgggag      120

cacaaccagc ugaacggcug guccagcgac gagaacgacu ggaacgagaa gcuguacccc      180

gucuggaagc gcggggacau gcgguggaag aacuccugga agggcgggcg cgugcaggcc      240

gugcucacca gcgacucccc cgcccugguc ggcagcaaca ucaccuucgc ggugaaccug      300

aucuuccccc ggugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

cgcaacgagg ccgggcucuc cgccgacccg uacgucuaca acuggacggc guggagcgag      420

gacuccgacg gcgagaacgg gaccggccag agccaccaca acguguuccc cgacgggaag      480

cccuuccccc accacccggg cuggcggcgc uggaacuuca ucuacguguu ccacacccug      540

gacuggcugc uccagacccc caagcugcug cucuaccugu cccugaaguu ccagcccagc      600

cucuuccugc uguacaacug a                                                621


<210>  1829
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPNMB/m__Homo_sapiens__CAD43718

<400>  1829
auggagugcc ucuacuacuu ccucggcuuc cuccuccucg ccgcccgccu cccccucgac       60

gccgccaagc gcuuccacga cguccucggc aacgagcgcc ccuccgccua caugcgcgag      120

cacaaccagc ucaacggcug guccuccgac gagaacgacu ggaacgagaa gcucuacccc      180

gucuggaagc gcggcgacau gcgcuggaag aacuccugga agggcggccg cguccaggcc      240

guccucaccu ccgacucccc cgcccucguc ggcuccaaca ucaccuucgc cgucaaccuc      300

aucuuccccc gcugccagaa ggaggacgcc aacggcaaca ucgucuacga gaagaacugc      360

cgcaacgagg ccggccucuc cgccgacccc uacgucuaca acuggaccgc cugguccgag      420

gacuccgacg gcgagaacgg caccggccag ucccaccaca acgucuuccc cgacggcaag      480

cccuuccccc accaccccgg cuggcgccgc uggaacuuca ucuacgucuu ccacacccuc      540

gacuggcucc uccagacccc caagcuccuc cucuaccucu cccucaaguu ccagcccucc      600

cucuuccucc ucuacaacug a                                                621


<210>  1830
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPNMB/m__Homo_sapiens__CAD43718

<400>  1830
auggagugcc uguacuauuu ccucggcuuu cuucuguugg ccgcuagauu accccuggac       60

gcagccaaga gguuccacga ugugcuaggg aacgaacggc cuagcgcgua caugcgcgag      120

cauaaucagc ucaacggaug guccucugac gaaaaugauu ggaacgagaa acuguaucca      180

gucuggaagc gaggugacau gcguuggaaa aauucaugga agggcgggag aguucaagcu      240

gugcuuacca gugauagccc ggcccuggua ggauccaaca ucacauuugc agugaauuug      300

auuuucccca ggugucagaa agaagacgcc aacggcaaua uagucuacga gaagaacugc      360

cggaaugagg cuggucucuc ugcagauccu uauguguaca acuggacugc cuggucggaa      420

gacucagaug gggagaaugg aacgggccag agccaccaua acguuuuucc agacggcaag      480

cccuucccuc accauccagg guggcgcaga uggaauuuua ucuauguguu ccacacccug      540

gauuggcugc uccagacacc caaauuacug cuuuacuuga gucugaaguu ucaaccuucc      600

cuauuccucc uguacaacug a                                                621


<210>  1831
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPNMB/m__Homo_sapiens__CAD43718

<400>  1831
auggagugcc uguacuacuu ccugggcuuc cugcugcugg ccgccagacu gccccuggac       60

gccgccaaga gauuccacga cgugcugggc aacgagagac ccagcgccua caugagagag      120

cacaaccagc ugaacggcug gagcagcgac gagaacgacu ggaacgagaa gcuguacccc      180

guguggaaga gaggcgacau gagauggaag aacagcugga agggcggcag agugcaggcc      240

gugcugacca gcgacagccc cgcccuggug ggcagcaaca ucaccuucgc cgugaaccug      300

aucuucccca gaugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

agaaacgagg ccggccugag cgccgacccc uacguguaca acuggaccgc cuggagcgag      420

gacagcgacg gcgagaacgg caccggccag agccaccaca acguguuccc cgacggcaag      480

cccuuccccc accaccccgg cuggagaaga uggaacuuca ucuacguguu ccacacccug      540

gacuggcugc ugcagacccc caagcugcug cuguaccuga gccugaaguu ccagcccagc      600

cuguuccugc uguacaacug a                                                621


<210>  1832
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPNMB/m__Homo_sapiens__CAD43718

<400>  1832
auggagugcc uguacuauuu ccucggcuuu cugcuucugg ccgcuagacu cccccuggac       60

gccgcgaagc gguuccacga ugugcuuggg aacgaacgcc cuagcgcuua caugagagag      120

cauaaucagc ugaacggaug guccucugac gaaaaugauu ggaacgagaa acucuauccg      180

gucuggaagc ggggcgacau gcgcuggaaa aauagcugga aagggggaag aguucaagcc      240

gugcugaccu ccgauucucc cgcccuggug ggcagcaaca ucacauuugc ugucaaucuc      300

auuuucccuc ggugucagaa ggaagacgcc aacgggaaua ucguguacga gaagaacugc      360

cgcaaugagg cuggacuguc cgccgauccc uauguuuaca acuggacggc guggucugaa      420

gacagcgaug gcgagaaugg caccgggcag ucccaccaua acguguuucc ugacggaaag      480

cccuucccuc accauccggg cuggagacgg uggaauuuua uuuaugucuu ccacacacuu      540

gauuggcugc uccagacccc caaacugcuu cuguaccuca gccugaaguu ucaaccuucu      600

cuguuccucc uguacaacug a                                                621


<210>  1833
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__Q96F58

<400>  1833

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Trp Leu Leu Gln Thr Pro Lys Leu Leu Leu Tyr 
            180                 185                 190         


Leu Ser Leu Lys Phe Gln Pro Ser Leu Phe Leu Leu Tyr Asn 
        195                 200                 205     


<210>  1834
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GPNMB/m__Homo_sapiens__AAH11595

<400>  1834
auggaauguc ucuacuauuu ccugggauuu cugcuccugg cugcaagauu gccacuugau       60

gccgccaaac gauuucauga ugugcugggc aaugaaagac cuucugcuua caugagggag      120

cacaaucaau uaaauggcug gucuucugau gaaaaugacu ggaaugaaaa acucuaccca      180

guguggaagc ggggagacau gagguggaaa aacuccugga agggaggccg ugugcaggcg      240

guccugacca gugacucacc agcccucgug ggcucaaaua uaacauuugc ggugaaccug      300

auauucccua gaugccaaaa ggaagaugcc aauggcaaca uagucuauga gaagaacugc      360

agaaaugagg cugguuuauc ugcugaucca uauguuuaca acuggacagc auggucagag      420

gacagugacg gggaaaaugg caccggccaa agccaucaua acgucuuccc ugaugggaaa      480

ccuuuuccuc accaccccgg auggagaaga uggaauuuca ucuacgucuu ccacacacuu      540

gguuggcuuu uacaaacccc uaagcuucuu cuuuaccuuu ccuuaaaauu ucaaccuucu      600

cuuuucuuac ucuauaauug a                                                621


<210>  1835
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GPNMB/m__Homo_sapiens__AAH11595

<400>  1835
auggagugcc uguacuacuu ccucggcuuc cugcugcucg ccgcccgccu gccccuggac       60

gcggccaagc gguuccacga cgugcucggg aacgagcgcc cgagcgccua caugcgggag      120

cacaaccagc ugaacggcug guccagcgac gagaacgacu ggaacgagaa gcuguacccc      180

gucuggaagc gcggggacau gcgguggaag aacuccugga agggcgggcg cgugcaggcc      240

gugcucacca gcgacucccc cgcccugguc ggcagcaaca ucaccuucgc ggugaaccug      300

aucuuccccc ggugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

cgcaacgagg ccgggcucuc cgccgacccg uacgucuaca acuggacggc guggagcgag      420

gacuccgacg gcgagaacgg gaccggccag agccaccaca acguguuccc cgacgggaag      480

cccuuccccc accacccggg cuggcggcgc uggaacuuca ucuacguguu ccacacccug      540

ggcuggcugc uccagacccc caagcugcug cucuaccugu cccugaaguu ccagcccagc      600

cucuuccugc uguacaacug a                                                621


<210>  1836
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GPNMB/m__Homo_sapiens__AAH11595

<400>  1836
auggagugcc ucuacuacuu ccucggcuuc cuccuccucg ccgcccgccu cccccucgac       60

gccgccaagc gcuuccacga cguccucggc aacgagcgcc ccuccgccua caugcgcgag      120

cacaaccagc ucaacggcug guccuccgac gagaacgacu ggaacgagaa gcucuacccc      180

gucuggaagc gcggcgacau gcgcuggaag aacuccugga agggcggccg cguccaggcc      240

guccucaccu ccgacucccc cgcccucguc ggcuccaaca ucaccuucgc cgucaaccuc      300

aucuuccccc gcugccagaa ggaggacgcc aacggcaaca ucgucuacga gaagaacugc      360

cgcaacgagg ccggccucuc cgccgacccc uacgucuaca acuggaccgc cugguccgag      420

gacuccgacg gcgagaacgg caccggccag ucccaccaca acgucuuccc cgacggcaag      480

cccuuccccc accaccccgg cuggcgccgc uggaacuuca ucuacgucuu ccacacccuc      540

ggcuggcucc uccagacccc caagcuccuc cucuaccucu cccucaaguu ccagcccucc      600

cucuuccucc ucuacaacug a                                                621


<210>  1837
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GPNMB/m__Homo_sapiens__AAH11595

<400>  1837
auggagugcc uguacuauuu ccucggcuuu cuucuguugg ccgcuagauu accccuggac       60

gcagccaaga gguuccacga ugugcuaggg aacgaacggc cuagcgcgua caugcgcgag      120

cauaaucagc ucaacggaug guccucugac gaaaaugauu ggaacgagaa acuguaucca      180

gucuggaagc gaggugacau gcguuggaaa aauucaugga agggcgggag aguucaagcu      240

gugcuuacca gugauagccc ggcccuggua ggauccaaca ucacauuugc agugaauuug      300

auuuucccca ggugucagaa agaagacgcc aacggcaaua uagucuacga gaagaacugc      360

cggaaugagg cuggucucuc ugcagauccu uauguguaca acuggacugc cuggucggaa      420

gacucagaug gggagaaugg aacgggccag agccaccaua acguuuuucc agacggcaag      480

cccuucccuc accauccagg guggcgcaga uggaauuuua ucuauguguu ccacacccug      540

ggauggcugc uccagacacc caaauuacug cuuuacuuga gucugaaguu ucaaccuucc      600

cuauuccucc uguacaacug a                                                621


<210>  1838
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GPNMB/m__Homo_sapiens__AAH11595

<400>  1838
auggagugcc uguacuacuu ccugggcuuc cugcugcugg ccgccagacu gccccuggac       60

gccgccaaga gauuccacga cgugcugggc aacgagagac ccagcgccua caugagagag      120

cacaaccagc ugaacggcug gagcagcgac gagaacgacu ggaacgagaa gcuguacccc      180

guguggaaga gaggcgacau gagauggaag aacagcugga agggcggcag agugcaggcc      240

gugcugacca gcgacagccc cgcccuggug ggcagcaaca ucaccuucgc cgugaaccug      300

aucuucccca gaugccagaa ggaggacgcc aacggcaaca ucguguacga gaagaacugc      360

agaaacgagg ccggccugag cgccgacccc uacguguaca acuggaccgc cuggagcgag      420

gacagcgacg gcgagaacgg caccggccag agccaccaca acguguuccc cgacggcaag      480

cccuuccccc accaccccgg cuggagaaga uggaacuuca ucuacguguu ccacacccug      540

ggcuggcugc ugcagacccc caagcugcug cuguaccuga gccugaaguu ccagcccagc      600

cuguuccugc uguacaacug a                                                621


<210>  1839
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GPNMB/m__Homo_sapiens__AAH11595

<400>  1839
auggagugcc uguacuauuu ccucggcuuu cugcuucugg ccgcuagacu cccccuggac       60

gccgcgaagc gguuccacga ugugcuuggg aacgaacgcc cuagcgcuua caugagagag      120

cauaaucagc ugaacggaug guccucugac gaaaaugauu ggaacgagaa acucuauccg      180

gucuggaagc ggggcgacau gcgcuggaaa aauagcugga aagggggaag aguucaagcc      240

gugcugaccu ccgauucucc cgcccuggug ggcagcaaca ucacauuugc ugucaaucuc      300

auuuucccuc ggugucagaa ggaagacgcc aacgggaaua ucguguacga gaagaacugc      360

cgcaaugagg cuggacuguc cgccgauccc uauguuuaca acuggacggc guggucugaa      420

gacagcgaug gcgagaaugg caccgggcag ucccaccaua acguguuucc ugacggaaag      480

cccuucccuc accauccggg cuggagacgg uggaauuuua uuuaugucuu ccacacacuu      540

ggguggcugc uccagacccc caaacugcuu cuguaccuca gccugaaguu ucaaccuucu      600

cuguuccucc uguacaacug a                                                621


<210>  1840
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GRM3__Homo_sapiens__Q14832

<400>  1840

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  1841
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GRM3__Homo_sapiens__CCDS5600.1

<400>  1841
augaagaugu ugacaagacu gcaaguucuu accuuagcuu uguuuucaaa gggauuuuua       60

cucucuuuag gggaccauaa cuuucuaagg agagagauua aaauagaagg ugaccuuguu      120

uuagggggcc uguuuccuau uaacgaaaaa ggcacuggaa cugaagaaug ugggcgaauc      180

aaugaagacc gagggauuca acgccuggaa gccauguugu uugcuauuga ugaaaucaac      240

aaagaugauu acuugcuacc aggagugaag uuggguguuc acauuuugga uacauguuca      300

agggauaccu augcauugga gcaaucacug gaguuuguca gggcaucuuu gacaaaagug      360

gaugaagcug aguauaugug uccugaugga uccuaugcca uucaagaaaa caucccacuu      420

cucauugcag gggucauugg uggcucuuau agcaguguuu ccauacaggu ggcaaaccug      480

cugcggcucu uccagauccc ucagaucagc uacgcaucca ccagcgccaa acucagugau      540

aagucgcgcu augauuacuu ugccaggacc gugccccccg acuucuacca ggccaaagcc      600

auggcugaga ucuugcgcuu cuucaacugg accuacgugu ccacaguagc cuccgagggu      660

gauuacgggg agacagggau cgaggccuuc gagcaggaag cccgccugcg caacaucugc      720

aucgcuacgg cggagaaggu gggccgcucc aacauccgca aguccuacga cagcgugauc      780

cgagaacugu ugcagaagcc caacgcgcgc gucguggucc ucuucaugcg cagcgacgac      840

ucgcgggagc ucauugcagc cgccagccgc gccaaugccu ccuucaccug gguggccagc      900

gacggcuggg gcgcgcagga gagcaucauc aagggcagcg agcauguggc cuacggcgcc      960

aucacccugg agcuggccuc ccagccuguc cgccaguucg accgcuacuu ccagagccuc     1020

aaccccuaca acaaccaccg caaccccugg uuccgggacu ucugggagca aaaguuucag     1080

ugcagccucc agaacaaacg caaccacagg cgcgucugcg acaagcaccu ggccaucgac     1140

agcagcaacu acgagcaaga guccaagauc auguuugugg ugaacgcggu guaugccaug     1200

gcccacgcuu ugcacaaaau gcagcgcacc cucuguccca acacuaccaa gcuuugugau     1260

gcuaugaaga uccuggaugg gaagaaguug uacaaggauu acuugcugaa aaucaacuuc     1320

acggcuccau ucaacccaaa uaaagaugca gauagcauag ucaaguuuga cacuuuugga     1380

gauggaaugg ggcgauacaa cguguucaau uuccaaaaug uagguggaaa guauuccuac     1440

uugaaaguug gucacugggc agaaaccuua ucgcuagaug ucaacucuau ccacuggucc     1500

cggaacucag uccccacuuc ccagugcagc gaccccugug cccccaauga aaugaagaau     1560

augcaaccag gggaugucug cugcuggauu ugcauccccu gugaacccua cgaauaccug     1620

gcugaugagu uuaccuguau ggauuguggg ucuggacagu ggcccacugc agaccuaacu     1680

ggaugcuaug accuuccuga ggacuacauc aggugggaag acgccugggc cauuggccca     1740

gucaccauug ccugucuggg uuuuaugugu acaugcaugg uuguaacugu uuuuaucaag     1800

cacaacaaca cacccuuggu caaagcaucg ggccgagaac ucugcuacau cuuauuguuu     1860

gggguuggcc ugucauacug caugacauuc uucuucauug ccaagccauc accagucauc     1920

ugugcauugc gccgacucgg gcuggggagu uccuucgcua ucuguuacuc agcccugcug     1980

accaagacaa acugcauugc ccgcaucuuc gaugggguca agaauggcgc ucagaggcca     2040

aaauucauca gccccaguuc ucagguuuuc aucugccugg gucugauccu ggugcaaauu     2100

gugauggugu cuguguggcu cauccuggag gccccaggca ccaggaggua uacccuugca     2160

gagaagcggg aaacagucau ccuaaaaugc aaugucaaag auuccagcau guugaucucu     2220

cuuaccuacg augugauccu ggugaucuua ugcacugugu acgccuucaa aacgcggaag     2280

ugcccagaaa auuucaacga agcuaaguuc auagguuuua ccauguacac cacgugcauc     2340

aucugguugg ccuuccuccc uauauuuuau gugacaucaa gugacuacag agugcagacg     2400

acaaccaugu gcaucucugu cagccugagu ggcuuugugg ucuugggcug uuuguuugca     2460

cccaagguuc acaucauccu guuucaaccc cagaagaaug uugucacaca cagacugcac     2520

cucaacaggu ucagugucag uggaacuggg accacauacu cucaguccuc ugcaagcacg     2580

uaugugccaa cggugugcaa ugggcgggaa guccucgacu ccaccaccuc aucucuguga     2640


<210>  1842
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GRM3__Homo_sapiens__CCDS5600.1

<400>  1842
augaagaugc ugacccgccu ccaggugcug acccuggccc ucuucagcaa gggcuuccug       60

cugucccucg gggaccacaa cuuccugcgg cgcgagauca agaucgaggg cgaccugguc      120

cucgggggcc uguuccccau caacgagaag gggacgggca ccgaggagug cggccggauc      180

aacgaggacc gcgggaucca gcggcuggag gccaugcugu ucgcgaucga cgagaucaac      240

aaggacgacu accuccugcc gggcgugaag cucggggugc acauccugga cacgugcagc      300

cgcgacaccu acgcccugga gcagucccuc gaguucgucc gggccagccu gaccaaggug      360

gacgaggccg aguacaugug ccccgacggc uccuacgcca uccaggagaa caucccccug      420

cucaucgcgg gggugaucgg cggcagcuac uccagcgucu ccauccaggu ggccaaccug      480

cugcgccucu uccagauccc ccagaucagc uacgccucca ccagcgccaa gcuguccgac      540

aagagccggu acgacuacuu cgcgcgcacc gugccgcccg acuucuacca ggccaaggcc      600

auggccgaga uccugcgguu cuucaacugg accuacgucu ccacgguggc cagcgagggg      660

gacuacggcg agaccgggau cgaggcguuc gagcaggagg cccgccuccg gaacaucugc      720

aucgccaccg ccgagaaggu gggccgcucc aacauccgca agagcuacga cuccgucauc      780

cgggagcugc ugcagaagcc caacgcccgg gugguggucc ucuucaugcg cagcgacgac      840

agccgggagc ugaucgcggc cgccucccgc gccaacgcca gcuucaccug gguggcgucc      900

gacggcuggg gcgcccagga gagcaucauc aagggguccg agcacguggc cuacggggcc      960

aucacgcugg agcucgccag ccagcccguc cggcaguucg accgcuacuu ccagucccug     1020

aacccguaca acaaccaccg caaccccugg uuccgggacu ucugggagca gaaguuccag     1080

ugcagccugc agaacaagcg caaccaccgg cgcgugugcg acaagcaccu cgcgaucgac     1140

uccagcaacu acgagcagga guccaagauc auguucgugg ucaacgccgu guacgccaug     1200

gcccacgcgc ugcacaagau gcagcggacc cugugcccca acaccaccaa gcucugcgac     1260

gccaugaaga uccuggacgg caagaagcug uacaaggacu accuccugaa gaucaacuuc     1320

acggcccccu ucaacccgaa caaggacgcc gacagcaucg ugaaguucga caccuucggg     1380

gacggcaugg gccgcuacaa cgucuucaac uuccagaacg ucgggggcaa guacuccuac     1440

cugaaggugg ggcacugggc cgagacccuc agccuggacg ugaacuccau ccacuggagc     1500

cggaacuccg ugcccaccag ccagugcucc gaccccugcg cgcccaacga gaugaagaac     1560

augcagccgg gcgacgucug cugcuggauc ugcauccccu gcgagcccua cgaguaccug     1620

gccgacgagu ucacgugcau ggacugcggg agcggccagu ggcccaccgc cgaccucacc     1680

ggcugcuacg accugccgga ggacuacauc cgcugggagg acgccugggc caucgggccc     1740

gugaccaucg cgugccuggg cuucaugugc acgugcaugg uggucaccgu guucaucaag     1800

cacaacaaca cgccccuggu gaaggccagc gggcgggagc ucugcuacau ccugcuguuc     1860

ggcgucgggc ucuccuacug caugaccuuc uucuucaucg ccaagcccag cccggugauc     1920

ugcgcccugc gccggcuggg ccucggcucc agcuucgcca ucugcuacuc cgcgcugcug     1980

accaagacca acugcaucgc ccgcaucuuc gacgggguga agaacggcgc ccagcggccc     2040

aaguucauca gccccuccag ccaggucuuc aucugccucg ggcugauccu ggugcagauc     2100

gugauggucu ccguguggcu cauccuggag gcccccggca cccgccggua cacccuggcg     2160

gagaagcgcg agacggugau ccucaagugc aacgucaagg acagcuccau gcugaucagc     2220

cugaccuacg acgugauccu cgugauccug ugcaccgucu acgccuucaa gacccggaag     2280

ugcccggaga acuucaacga ggccaaguuc aucggcuuca cgauguacac gaccugcauc     2340

aucuggcugg ccuuccuccc caucuucuac gugaccucca gcgacuaccg cgugcagacc     2400

accaccaugu gcaucuccgu cagccugucc ggguucgugg ugcugggcug ccucuucgcc     2460

cccaaggucc acaucauccu guuccagccg cagaagaacg uggugaccca ccggcugcac     2520

cucaaccgcu ucagcgucag cgggaccggc acgaccuacu cccagagcuc cgcgagcacc     2580

uacgugccca ccgugugcaa cgggcgcgag guccuggacu ccacgaccag cucccuguga     2640


<210>  1843
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GRM3__Homo_sapiens__CCDS5600.1

<400>  1843
augaagaugc ucacccgccu ccagguccuc acccucgccc ucuucuccaa gggcuuccuc       60

cucucccucg gcgaccacaa cuuccuccgc cgcgagauca agaucgaggg cgaccucguc      120

cucggcggcc ucuuccccau caacgagaag ggcaccggca ccgaggagug cggccgcauc      180

aacgaggacc gcggcaucca gcgccucgag gccaugcucu ucgccaucga cgagaucaac      240

aaggacgacu accuccuccc cggcgucaag cucggcgucc acauccucga caccugcucc      300

cgcgacaccu acgcccucga gcagucccuc gaguucgucc gcgccucccu caccaagguc      360

gacgaggccg aguacaugug ccccgacggc uccuacgcca uccaggagaa caucccccuc      420

cucaucgccg gcgucaucgg cggcuccuac uccuccgucu ccauccaggu cgccaaccuc      480

cuccgccucu uccagauccc ccagaucucc uacgccucca ccuccgccaa gcucuccgac      540

aagucccgcu acgacuacuu cgcccgcacc gucccccccg acuucuacca ggccaaggcc      600

auggccgaga uccuccgcuu cuucaacugg accuacgucu ccaccgucgc cuccgagggc      660

gacuacggcg agaccggcau cgaggccuuc gagcaggagg cccgccuccg caacaucugc      720

aucgccaccg ccgagaaggu cggccgcucc aacauccgca aguccuacga cuccgucauc      780

cgcgagcucc uccagaagcc caacgcccgc gucgucgucc ucuucaugcg cuccgacgac      840

ucccgcgagc ucaucgccgc cgccucccgc gccaacgccu ccuucaccug ggucgccucc      900

gacggcuggg gcgcccagga guccaucauc aagggcuccg agcacgucgc cuacggcgcc      960

aucacccucg agcucgccuc ccagcccguc cgccaguucg accgcuacuu ccagucccuc     1020

aaccccuaca acaaccaccg caaccccugg uuccgcgacu ucugggagca gaaguuccag     1080

ugcucccucc agaacaagcg caaccaccgc cgcgucugcg acaagcaccu cgccaucgac     1140

uccuccaacu acgagcagga guccaagauc auguucgucg ucaacgccgu cuacgccaug     1200

gcccacgccc uccacaagau gcagcgcacc cucugcccca acaccaccaa gcucugcgac     1260

gccaugaaga uccucgacgg caagaagcuc uacaaggacu accuccucaa gaucaacuuc     1320

accgcccccu ucaaccccaa caaggacgcc gacuccaucg ucaaguucga caccuucggc     1380

gacggcaugg gccgcuacaa cgucuucaac uuccagaacg ucggcggcaa guacuccuac     1440

cucaaggucg gccacugggc cgagacccuc ucccucgacg ucaacuccau ccacuggucc     1500

cgcaacuccg uccccaccuc ccagugcucc gaccccugcg cccccaacga gaugaagaac     1560

augcagcccg gcgacgucug cugcuggauc ugcauccccu gcgagcccua cgaguaccuc     1620

gccgacgagu ucaccugcau ggacugcggc uccggccagu ggcccaccgc cgaccucacc     1680

ggcugcuacg accuccccga ggacuacauc cgcugggagg acgccugggc caucggcccc     1740

gucaccaucg ccugccucgg cuucaugugc accugcaugg ucgucaccgu cuucaucaag     1800

cacaacaaca ccccccucgu caaggccucc ggccgcgagc ucugcuacau ccuccucuuc     1860

ggcgucggcc ucuccuacug caugaccuuc uucuucaucg ccaagcccuc ccccgucauc     1920

ugcgcccucc gccgccucgg ccucggcucc uccuucgcca ucugcuacuc cgcccuccuc     1980

accaagacca acugcaucgc ccgcaucuuc gacggcguca agaacggcgc ccagcgcccc     2040

aaguucaucu cccccuccuc ccaggucuuc aucugccucg gccucauccu cguccagauc     2100

gucauggucu ccgucuggcu cauccucgag gcccccggca cccgccgcua cacccucgcc     2160

gagaagcgcg agaccgucau ccucaagugc aacgucaagg acuccuccau gcucaucucc     2220

cucaccuacg acgucauccu cgucauccuc ugcaccgucu acgccuucaa gacccgcaag     2280

ugccccgaga acuucaacga ggccaaguuc aucggcuuca ccauguacac caccugcauc     2340

aucuggcucg ccuuccuccc caucuucuac gucaccuccu ccgacuaccg cguccagacc     2400

accaccaugu gcaucuccgu cucccucucc ggcuucgucg uccucggcug ccucuucgcc     2460

cccaaggucc acaucauccu cuuccagccc cagaagaacg ucgucaccca ccgccuccac     2520

cucaaccgcu ucuccgucuc cggcaccggc accaccuacu cccaguccuc cgccuccacc     2580

uacgucccca ccgucugcaa cggccgcgag guccucgacu ccaccaccuc cucccucuga     2640


<210>  1844
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GRM3__Homo_sapiens__CCDS5600.1

<400>  1844
augaagaugc ugaccagacu ccaggugcuu acacuggccu uguucagcaa aggcuuuuua       60

cugucccuag gggaccacaa cuuccucagg cgggagauca agauugaagg agaucugguc      120

cuugguggcc uguuucccau aaaugagaaa gggacuggaa cggaagagug cggccgcauc      180

aacgaagacc gagguauuca acguuuggag gcuaugcugu ucgcaaucga ugagauuaau      240

aaggacgauu accuccugcc ugggguuaaa cucggagugc auaucuuaga caccuguucu      300

agagauacau augcccugga acagucacuu gaguuuguaa gggcgaguuu gacuaaggug      360

gacgaagcug aguacaugug cccagauggc agcuaugcca uacaggagaa caucccgcug      420

cuaauugcag gcgucaucgg gggauccuac ucuucggugu caauucaggu ugccaaucuc      480

cugcggcuuu uccaaauccc ccagauaagc uaugcuagua ccuccgcaaa gcugucugac      540

aaaagccgcu acgauuauuu ugccagaaca gugccuccag acuucuacca ggcuaaggcc      600

auggcggaaa uuuugagguu uuucaacugg accuacgucu ccacuguggc aucagagggu      660

gauuauggcg aaacagggau cgaggccuuu gaacaggagg cucggcuccg caauauuugu      720

aucgccaccg cagagaaagu aggacgaagu aacaucagaa agagcuacga cucuguuauu      780

agggaacugu uacaaaaacc caaugcucgg guggucgugc uguucaugcg uuccgacgau      840

ucacgcgagc ucauagccgc ggccagcaga gcaaacgcua guuuuacgug gguggccucu      900

gacggcuggg gugcucagga auccaucauu aaggggagcg agcacgucgc cuauggagca      960

aucacucuug aacuggccuc gcagccuguu aggcaguucg aucgguacuu ccaaucuuug     1020

aauccauaua acaaucaucg aaaccccugg uuucgcgacu ucugggagca gaaguuucag     1080

ugcucccuac aaaauaaaag aaaccacagg cgggugugug auaagcaucu ggcuauagac     1140

ucaaguaacu acgagcagga aagcaaaauu auguucguag ugaaugcggu cuaugcaaug     1200

gcccacgcuc uccacaagau gcagcgcacc cugugcccua acacaacuaa acuuugugau     1260

gccaugaaga uccuggacgg caaaaaguug uacaaggauu accuccugaa aaucaauuuu     1320

accgcaccau ucaacccgaa uaaggacgcc gauuccauug ugaaauuuga cacauucggc     1380

gacgggaugg gaagauauaa cguuuuuaau uuccagaacg uggguggcaa guacucuuau     1440

uuaaaagucg ggcauugggc ugagacccug agccuagaug uaaauucaau ccacuggagu     1500

aggaacuccg ugcccacgag ccaaugcucu gacccuugug ccccaaauga aaugaagaac     1560

augcagcccg gagauguuug cuguuggauu ugcauaccuu gcgagccaua cgaauaucuc     1620

gcagacgagu uuacuuguau ggauugcggc ucaggucagu ggcccacagc ggaccugacc     1680

ggguguuacg aucuuccgga ggacuauauc cguugggaag augcuugggc cauuggcccu     1740

gugacuaucg caugcuuggg auucaugugu acaugcaugg ucgugaccgu cuuuaucaag     1800

cauaauaaca cgccccuggu gaaagccagu ggccgggagc ucuguuacau ucugcuuuuc     1860

gggguuggac ugagcuacug caugaccuuc uuuuucauag cuaagccauc cccugugauc     1920

ugugccuugc gaagacucgg ucuggggucu ucguuugcaa uuugcuauag cgcuuuacug     1980

acaaaaacua auuguaucgc caggauuuuc gacggcguaa agaacggagc gcagcgcccc     2040

aaauuuaucu ccccaucaag ucaagucuuc auaugccuag gccucauccu ggugcagauu     2100

guuauggugu cugucuggcu uaucuuggaa gcccccggua cccggagaua cacacuggcu     2160

gagaagaggg agacugugau ucucaagugc aacguaaaag auagcuccau gcugaucuca     2220

uuaaccuaug acgugauacu gguuauucuu uguacagucu acgcauuuaa gacccgcaaa     2280

ugcccugaaa auuucaacga ggccaaguuu aucggguuca cuauguauac gacauguauu     2340

aucugguugg cuuuucuccc aauauucuac gugaccagcu cugauuaucg agugcagacu     2400

accacaaugu gcaucuccgu cagucugagc ggcuuuguug ugcuaggaug ucuguucgcc     2460

ccgaaagugc acauuauccu cuuccagccc caaaagaaug uagucaccca ccggcugcau     2520

cuuaaccguu uuucuguguc cggcacuggg acaacguacu cacagaguag cgcaucgacc     2580

uacguuccua cugugugcaa uggaagagaa gucuuggacu ccacaaccuc uagccuguga     2640


<210>  1845
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GRM3__Homo_sapiens__CCDS5600.1

<400>  1845
augaagaugc ugaccagacu gcaggugcug acccuggccc uguucagcaa gggcuuccug       60

cugagccugg gcgaccacaa cuuccugaga agagagauca agaucgaggg cgaccuggug      120

cugggcggcc uguuccccau caacgagaag ggcaccggca ccgaggagug cggcagaauc      180

aacgaggaca gaggcaucca gagacuggag gccaugcugu ucgccaucga cgagaucaac      240

aaggacgacu accugcugcc cggcgugaag cugggcgugc acauccugga caccugcagc      300

agagacaccu acgcccugga gcagagccug gaguucguga gagccagccu gaccaaggug      360

gacgaggccg aguacaugug ccccgacggc agcuacgcca uccaggagaa caucccccug      420

cugaucgccg gcgugaucgg cggcagcuac agcagcguga gcauccaggu ggccaaccug      480

cugagacugu uccagauccc ccagaucagc uacgccagca ccagcgccaa gcugagcgac      540

aagagcagau acgacuacuu cgccagaacc gugccccccg acuucuacca ggccaaggcc      600

auggccgaga uccugagauu cuucaacugg accuacguga gcaccguggc cagcgagggc      660

gacuacggcg agaccggcau cgaggccuuc gagcaggagg ccagacugag aaacaucugc      720

aucgccaccg ccgagaaggu gggcagaagc aacaucagaa agagcuacga cagcgugauc      780

agagagcugc ugcagaagcc caacgccaga gugguggugc uguucaugag aagcgacgac      840

agcagagagc ugaucgccgc cgccagcaga gccaacgcca gcuucaccug gguggccagc      900

gacggcuggg gcgcccagga gagcaucauc aagggcagcg agcacguggc cuacggcgcc      960

aucacccugg agcuggccag ccagcccgug agacaguucg acagauacuu ccagagccug     1020

aaccccuaca acaaccacag aaaccccugg uucagagacu ucugggagca gaaguuccag     1080

ugcagccugc agaacaagag aaaccacaga agagugugcg acaagcaccu ggccaucgac     1140

agcagcaacu acgagcagga gagcaagauc auguucgugg ugaacgccgu guacgccaug     1200

gcccacgccc ugcacaagau gcagagaacc cugugcccca acaccaccaa gcugugcgac     1260

gccaugaaga uccuggacgg caagaagcug uacaaggacu accugcugaa gaucaacuuc     1320

accgcccccu ucaaccccaa caaggacgcc gacagcaucg ugaaguucga caccuucggc     1380

gacggcaugg gcagauacaa cguguucaac uuccagaacg ugggcggcaa guacagcuac     1440

cugaaggugg gccacugggc cgagacccug agccuggacg ugaacagcau ccacuggagc     1500

agaaacagcg ugcccaccag ccagugcagc gaccccugcg cccccaacga gaugaagaac     1560

augcagcccg gcgacgugug cugcuggauc ugcauccccu gcgagcccua cgaguaccug     1620

gccgacgagu ucaccugcau ggacugcggc agcggccagu ggcccaccgc cgaccugacc     1680

ggcugcuacg accugcccga ggacuacauc agaugggagg acgccugggc caucggcccc     1740

gugaccaucg ccugccuggg cuucaugugc accugcaugg uggugaccgu guucaucaag     1800

cacaacaaca ccccccuggu gaaggccagc ggcagagagc ugugcuacau ccugcuguuc     1860

ggcgugggcc ugagcuacug caugaccuuc uucuucaucg ccaagcccag ccccgugauc     1920

ugcgcccuga gaagacuggg ccugggcagc agcuucgcca ucugcuacag cgcccugcug     1980

accaagacca acugcaucgc cagaaucuuc gacggcguga agaacggcgc ccagagaccc     2040

aaguucauca gccccagcag ccagguguuc aucugccugg gccugauccu ggugcagauc     2100

gugaugguga gcguguggcu gauccuggag gcccccggca ccagaagaua cacccuggcc     2160

gagaagagag agaccgugau ccugaagugc aacgugaagg acagcagcau gcugaucagc     2220

cugaccuacg acgugauccu ggugauccug ugcaccgugu acgccuucaa gaccagaaag     2280

ugccccgaga acuucaacga ggccaaguuc aucggcuuca ccauguacac caccugcauc     2340

aucuggcugg ccuuccugcc caucuucuac gugaccagca gcgacuacag agugcagacc     2400

accaccaugu gcaucagcgu gagccugagc ggcuucgugg ugcugggcug ccuguucgcc     2460

cccaaggugc acaucauccu guuccagccc cagaagaacg uggugaccca cagacugcac     2520

cugaacagau ucagcgugag cggcaccggc accaccuaca gccagagcag cgccagcacc     2580

uacgugccca ccgugugcaa cggcagagag gugcuggaca gcaccaccag cagccuguga     2640


<210>  1846
<211>  2640
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GRM3__Homo_sapiens__CCDS5600.1

<400>  1846
augaagaugc ugaccagacu ccaggugcug acacuugccc uguucagcaa aggcuuucuc       60

cugucccuug gggaccacaa cuuccugcgg cgcgagauca agauugaagg agaucucguc      120

cugggcgggc uguuucccau caaugagaaa ggaacgggca ccgaagagug cgggagaauu      180

aacgaagacc ggggaaucca acgccucgag gcuaugcugu ucgccauuga ugagaucaau      240

aaggacgauu accuucugcc uggcguuaaa cucggcgugc auauccugga cacauguucu      300

agagauaccu augcgcuuga acagagccug gaguuugugc gggcuucccu cacaaagguc      360

gacgaagccg aguacaugug cccggauggg ucuuaugcca uucaggagaa caucccccug      420

cugauugcug gagugaucgg cgggagcuac uccucuguua gcauucaggu ggccaaucuc      480

cugcgccuuu uccaaauccc ucagauuucc uaugcuagca ccucugccaa gcuguccgac      540

aaaagcagau acgauuauuu ugcgcggaca gugcccccug acuucuacca ggccaaggcu      600

auggccgaaa uccuccgcuu uuucaacugg accuacgucu cuacgguugc uuccgaggga      660

gauuauggcg aaaccgggau cgaggccuuu gaacaggagg cgagacugcg gaauauuugu      720

aucgccacag cugagaaagu gggacgcagc aacauuagaa agucuuacga cuccgucauc      780

cgggaacuuc ugcaaaaacc caaugcccgc gugguggucc ucuucaugag aagcgacgau      840

ucccgggagc ugauugcugc cgccucuaga gcuaacgcga gcuuuaccug gguugccucc      900

gacggcuggg gcgcucagga aagcaucauc aaggggucug agcacguggc cuauggagcc      960

auuacacugg aacucgcuuc ccagccugug cgccaguucg aucgguacuu ccaaagccug     1020

aauccguaua acaaucauag aaaccccugg uuucgcgacu ucugggagca gaaguuucag     1080

ugcucucuuc aaaauaaacg gaaccacaga cgcgucugug auaagcaucu ggccaucgac     1140

agcuccaacu acgagcagga aucuaaaauu auguucgugg uuaaugcggu guaugcuaug     1200

gcccacgccc uccacaagau gcagcggacc cugugcccua acacgacaaa acuuugugau     1260

gcuaugaaga uccuggacgg caaaaagcuc uacaaggauu accugcugaa aauuaauuuu     1320

accgcccccu ucaacccuaa uaaggacgcu gauagcaucg ucaaauuuga cacauucggg     1380

gacggaaugg gcagauauaa cguguuuaau uuccagaacg uugggggaaa guacuccuau     1440

cucaaagugg gccauugggc cgagacccug agccuugaug ucaauucuau ccacuggucc     1500

cgcaacagcg ugcccaccuc ucaaugcucc gacccgugug cgccuaauga aaugaagaac     1560

augcagcccg gcgaugucug cuguuggauu ugcaucccuu gcgagcccua cgaauaucug     1620

gccgacgagu uuacauguau ggauugcggg agcggacagu ggcccacggc ugaccucacc     1680

ggcuguuacg aucugccuga ggacuauauu cggugggaag augccugggc uaucgggccg     1740

gugacaauug ccugccuggg auucaugugu accugcaugg uugugacagu cuuuaucaag     1800

cauaauaaca cgccccuugu gaaagcgucc ggcagagagc ucuguuacau ucugcuguuc     1860

gggguuggcc ucucuuacug caugaccuuc uuuuucaucg ccaagccuag ccccgugauc     1920

ugugcucugc gccggcuugg acugggcucc ucuuuugcca uuugcuauag cgcucuccug     1980

acaaaaacca auuguaucgc cagaauuuuc gacgggguca agaacggagc ccagcggccu     2040

aaauuuaucu cccccagcuc ucaaguguuc auuugccugg gccuuauccu cgugcagauc     2100

guuauggucu ccguguggcu gauucuggaa gcuccgggga cccgcagaua cacacucgcg     2160

gagaagcggg agaccgugau ccugaagugc aacgucaaag auagcucuau gcuuauuucc     2220

cugacauaug acgugauccu cguuauucug uguacggugu acgccuuuaa gaccagaaaa     2280

ugcccugaaa auuucaacga ggcuaaguuu aucggauuca caauguauac cacauguauc     2340

auuuggcugg ccuuucuucc caucuucuac gucaccagcu cugauuaucg cgugcagacg     2400

accacaaugu gcauuagcgu uucccucagc ggcuuugugg uccuggggug ucuguucgcc     2460

ccuaaagugc acaucauucu cuuccagccc caaaagaaug uugugaccca ccggcugcau     2520

cuuaacagau uuucugucuc cggcacagga accacguaca gccaguccuc ugcuagcaca     2580

uacgugccua ccgugugcaa uggccgcgaa guccuggacu ccacaaccuc uagccucuga     2640


<210>  1847
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAGE__Homo_sapiens__Q9NXZ2

<400>  1847

Met Ser His His Gly Gly Ala Pro Lys Ala Ser Thr Trp Val Val Ala 
1               5                   10                  15      


Ser Arg Arg Ser Ser Thr Val Ser Arg Ala Pro Glu Arg Arg Pro Ala 
            20                  25                  30          


Glu Glu Leu Asn Arg Thr Gly Pro Glu Gly Tyr Ser Val Gly Arg Gly 
        35                  40                  45              


Gly Arg Trp Arg Gly Thr Ser Arg Pro Pro Glu Ala Val Ala Ala Gly 
    50                  55                  60                  


His Glu Glu Leu Pro Leu Cys Phe Ala Leu Lys Ser His Phe Val Gly 
65                  70                  75                  80  


Ala Val Ile Gly Arg Gly Gly Ser Lys Ile Lys Asn Ile Gln Ser Thr 
                85                  90                  95      


Thr Asn Thr Thr Ile Gln Ile Ile Gln Glu Gln Pro Glu Ser Leu Val 
            100                 105                 110         


Lys Ile Phe Gly Ser Lys Ala Met Gln Thr Lys Ala Lys Ala Val Ile 
        115                 120                 125             


Asp Asn Phe Val Lys Lys Leu Glu Glu Asn Tyr Asn Ser Glu Cys Gly 
    130                 135                 140                 


Ile Asp Thr Ala Phe Gln Pro Ser Val Gly Lys Asp Gly Ser Thr Asp 
145                 150                 155                 160 


Asn Asn Val Val Ala Gly Asp Arg Pro Leu Ile Asp Trp Asp Gln Ile 
                165                 170                 175     


Arg Glu Glu Gly Leu Lys Trp Gln Lys Thr Lys Trp Ala Asp Leu Pro 
            180                 185                 190         


Pro Ile Lys Lys Asn Phe Tyr Lys Glu Ser Thr Ala Thr Ser Ala Met 
        195                 200                 205             


Ser Lys Val Glu Ala Asp Ser Trp Arg Lys Glu Asn Phe Asn Ile Thr 
    210                 215                 220                 


Trp Asp Asp Leu Lys Asp Gly Glu Lys Arg Pro Ile Pro Asn Pro Thr 
225                 230                 235                 240 


Cys Thr Phe Asp Asp Ala Phe Gln Cys Tyr Pro Glu Val Met Glu Asn 
                245                 250                 255     


Ile Lys Lys Ala Gly Phe Gln Lys Pro Thr Pro Ile Gln Ser Gln Ala 
            260                 265                 270         


Trp Pro Ile Val Leu Gln Gly Ile Asp Leu Ile Gly Val Ala Gln Thr 
        275                 280                 285             


Gly Thr Gly Lys Thr Leu Cys Tyr Leu Met Pro Gly Phe Ile His Leu 
    290                 295                 300                 


Val Leu Gln Pro Ser Leu Lys Gly Gln Arg Asn Arg Pro Gly Met Leu 
305                 310                 315                 320 


Val Leu Thr Pro Thr Arg Glu Leu Ala Leu Gln Val Glu Gly Glu Cys 
                325                 330                 335     


Cys Lys Tyr Ser Tyr Lys Gly Leu Arg Ser Val Cys Val Tyr Gly Gly 
            340                 345                 350         


Gly Asn Arg Asp Glu Gln Ile Glu Glu Leu Lys Lys Gly Val Asp Ile 
        355                 360                 365             


Ile Ile Ala Thr Pro Gly Arg Leu Asn Asp Leu Gln Met Ser Asn Phe 
    370                 375                 380                 


Val Asn Leu Lys Asn Ile Thr Tyr Leu Val Leu Asp Glu Ala Asp Lys 
385                 390                 395                 400 


Met Leu Asp Met Gly Phe Glu Pro Gln Ile Met Lys Ile Leu Leu Asp 
                405                 410                 415     


Val Arg Pro Asp Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro His 
            420                 425                 430         


Ser Val His Arg Leu Ala Gln Ser Tyr Leu Lys Glu Pro Met Ile Val 
        435                 440                 445             


Tyr Val Gly Thr Leu Asp Leu Val Ala Val Ser Ser Val Lys Gln Asn 
    450                 455                 460                 


Ile Ile Val Thr Thr Glu Glu Glu Lys Trp Ser His Met Gln Thr Phe 
465                 470                 475                 480 


Leu Gln Ser Met Ser Ser Thr Asp Lys Val Ile Val Phe Val Ser Arg 
                485                 490                 495     


Lys Ala Val Ala Asp His Leu Ser Ser Asp Leu Ile Leu Gly Asn Ile 
            500                 505                 510         


Ser Val Glu Ser Leu His Gly Asp Arg Glu Gln Arg Asp Arg Glu Lys 
        515                 520                 525             


Ala Leu Glu Asn Phe Lys Thr Gly Lys Val Arg Ile Leu Ile Ala Thr 
    530                 535                 540                 


Asp Leu Ala Ser Arg Gly Leu Asp Val His Asp Val Thr His Val Tyr 
545                 550                 555                 560 


Asn Phe Asp Phe Pro Arg Asn Ile Glu Glu Tyr Val His Arg Ile Gly 
                565                 570                 575     


Arg Thr Gly Arg Ala Gly Arg Thr Gly Val Ser Ile Thr Thr Leu Thr 
            580                 585                 590         


Arg Asn Asp Trp Arg Val Ala Ser Glu Leu Ile Asn Ile Leu Glu Arg 
        595                 600                 605             


Ala Asn Gln Ser Ile Pro Glu Glu Leu Val Ser Met Ala Glu Arg Phe 
    610                 615                 620                 


Lys Ala His Gln Gln Lys Arg Glu Met Glu Arg Lys Met Glu Arg Pro 
625                 630                 635                 640 


Gln Gly Arg Pro Lys Lys Phe His 
                645             


<210>  1848
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HAGE__Homo_sapiens__CCDS4977.1

<400>  1848
augucccacc acggaggagc ucccaaggcc ucuacguggg ucguugcuag ucggcgaagc       60

ucgacagugu cccgagcgcc agagaggagg ccggcggagg aguugaaucg aacagguccu      120

gagggauaua gugucggcag agguggucgc uggagaggca ccucuaggcc cccggaggcc      180

guggccgcug gucacgagga acugccgcug uguuuugcuu ugaagagcca cuuuguuggc      240

gcgguaaucg gucguggugg gucaaaaaua aagaauauac aaaguacaac aaacaccaca      300

auccaaauaa uacaagaaca accagaauca uuagucaaaa uuuuuggcag caaggcaaug      360

caaacgaaag caaaagcagu gauagacaau uuuguuaaaa agcuagaaga aaauuacaau      420

ucagaaugcg gaauugauac ugcauuccaa ccuucuguug gaaaagaugg aagcacagau      480

aacaauguug uugcaggaga ucggccauug auagauuggg aucaaauuag agaggaaggu      540

uugaaauggc aaaaaacaaa gugggcagau uuaccaccaa uuaagaaaaa cuuuuauaaa      600

gaguccacug ccacaagugc caugucaaaa guagaagcag auaguuggag gaaagaaaau      660

uuuaauauaa cgugggauga cuugaaggau ggggagaaac gaccuauccc caauccuacc      720

ugcacauuug augacgccuu ucaauguuau ccugagguua uggaaaacau uaaaaaggca      780

gguuuucaaa agccaacacc uauucaguca caggcauggc ccauuguguu gcaaggaaua      840

gaucuuauag gaguagccca gacuggaaca ggaaagacau uguguuauuu aaugccugga      900

uuuauucauc ugguccuuca acccagccuu aaaggucaaa ggaauagacc cggcauguua      960

guucuaacuc ccacucggga auuagcacuu caaguagaag gagaauguug caaauauuca     1020

uauaaagggc uucggagugu uuguguauau ggugguggaa auagagauga acaaauagaa     1080

gagcuuaaaa aagguguaga uaucauaauu gcaacucccg gaagauugaa ugaucugcaa     1140

augaguaacu ucgucaaucu gaagaauaua accuacuugg uuuuagauga agcagacaag     1200

auguuggaca ugggauuuga accccagaua augaagauuu uguuagaugu gcgcccagau     1260

aggcagacag uuaugaccag ugcuacaugg ccucauucag uucaucgccu cgcacaaucu     1320

uauuugaaag aaccaaugau ugucuauguu gguacauugg aucuaguugc uguaaguuca     1380

gugaagcaaa auauaauugu aaccaccgag gaagagaaau ggagucacau gcaaacuuuu     1440

cuacagagua ugucauccac agacaaaguc auugucuucg uuucucgaaa agcuguugcg     1500

gaucacuuau caagugaccu aauacuugga aauauaucag uagagucucu gcauggagau     1560

agagaacaga gagaucggga gaaagcauua gagaacuuua aaacaggcaa agugagaaua     1620

cuaauugcaa cugaucuagc cucuagagga cuugaugucc augacguuac acaugucuau     1680

aauuuugacu uuccacggaa uauugaagaa uacguacacc gaauagggcg cacgggaaga     1740

gcagggagga cugguguuuc cauuacaacu uugacuagaa augauuggag gguugccucu     1800

gaauugauua auauucugga aagagcaaau cagaguauuc cagaggagcu uguaucaaug     1860

gcugagaggu uuaaggcaca ucaacagaaa agggaaaugg aaagaaaaau ggaaagaccu     1920

caaggaaggc ccaagaaguu ucauuaa                                         1947


<210>  1849
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HAGE__Homo_sapiens__CCDS4977.1

<400>  1849
augagccacc acggcggggc ccccaaggcc uccaccuggg uggucgcgag ccgccggucc       60

agcaccgugu cccgcgcccc ggagcggcgc cccgccgagg agcugaaccg gacgggcccc      120

gagggguaca gcgugggccg cgggggccgg uggcgcggca ccucccggcc cccggaggcc      180

gucgccgcgg ggcacgagga gcucccccug ugcuucgccc ucaagagcca cuucgugggc      240

gccgugaucg ggcgcggcgg guccaagauc aagaacaucc agagcaccac caacacgacc      300

auccagauca uccaggagca gcccgagucc cuggucaaga ucuucggcag caaggccaug      360

cagaccaagg cgaaggccgu gaucgacaac uucgugaaga agcuggagga gaacuacaac      420

uccgagugcg gcaucgacac cgccuuccag cccagcgucg ggaaggacgg cuccacggac      480

aacaacgugg uggccgggga ccggccgcug aucgacuggg accagauccg cgaggagggc      540

cucaaguggc agaagaccaa gugggccgac cugccgccca ucaagaagaa cuucuacaag      600

gagagcaccg cgaccuccgc caugagcaag gucgaggccg acuccuggcg gaaggagaac      660

uucaacauca cgugggacga ccugaaggac ggcgagaagc gccccauccc caacccgacc      720

ugcaccuucg acgacgccuu ccagugcuac cccgagguga uggagaacau caagaaggcc      780

ggguuccaga agcccacccc cauccagagc caggcguggc ccaucgugcu ccagggcauc      840

gaccugaucg gggucgccca gacgggcacc gggaagaccc ugugcuaccu caugcccggc      900

uucauccacc uggugcugca gcccagccuc aagggccagc ggaaccgccc ggggaugcug      960

gugcugaccc ccacgcggga gcucgcccug caggucgagg gcgagugcug caaguacucc     1020

uacaaggggc ugcgcagcgu gugcguguac ggcgggggca accgggacga gcagaucgag     1080

gagcucaaga agggcgucga caucaucauc gccacccccg ggcgccugaa cgaccugcag     1140

auguccaacu ucgugaaccu caagaacauc accuaccugg ugcuggacga ggccgacaag     1200

augcucgaca ugggcuucga gccccagauc augaagaucc ugcuggacgu ccggccggac     1260

cgccagaccg ugaugacgag cgcgaccugg ccccacuccg uccaccgccu cgcccagagc     1320

uaccugaagg agcccaugau cguguacgug gggacccugg accucgucgc cguguccagc     1380

gugaagcaga acaucaucgu caccacggag gaggagaagu ggucccacau gcagaccuuc     1440

cugcagagca uguccagcac cgacaaggug aucguguucg ucucccggaa ggccguggcc     1500

gaccaccuga gcuccgaccu cauccugggc aacaucagcg uggagucccu gcacggggac     1560

cgcgagcagc gggaccgcga gaaggcgcuc gagaacuuca agaccggcaa gguccggauc     1620

cugaucgcca cggaccuggc cagccgcggc cucgacgugc acgacgugac ccacgucuac     1680

aacuucgacu ucccccggaa caucgaggag uacgugcacc gcaucgggcg gaccggccgc     1740

gccgggcgga ccggcguguc caucacgacc cugacccgca acgacuggcg ggucgcgagc     1800

gagcugauca acauccucga gcgcgccaac cagagcaucc cggaggagcu gguguccaug     1860

gccgagcggu ucaaggccca ccagcagaag cgcgagaugg agcggaagau ggagcgcccc     1920

cagggccggc ccaagaaguu ccacuga                                         1947


<210>  1850
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HAGE__Homo_sapiens__CCDS4977.1

<400>  1850
augucccacc acggcggcgc ccccaaggcc uccaccuggg ucgucgccuc ccgccgcucc       60

uccaccgucu cccgcgcccc cgagcgccgc cccgccgagg agcucaaccg caccggcccc      120

gagggcuacu ccgucggccg cggcggccgc uggcgcggca ccucccgccc ccccgaggcc      180

gucgccgccg gccacgagga gcucccccuc ugcuucgccc ucaaguccca cuucgucggc      240

gccgucaucg gccgcggcgg cuccaagauc aagaacaucc aguccaccac caacaccacc      300

auccagauca uccaggagca gcccgagucc cucgucaaga ucuucggcuc caaggccaug      360

cagaccaagg ccaaggccgu caucgacaac uucgucaaga agcucgagga gaacuacaac      420

uccgagugcg gcaucgacac cgccuuccag cccuccgucg gcaaggacgg cuccaccgac      480

aacaacgucg ucgccggcga ccgcccccuc aucgacuggg accagauccg cgaggagggc      540

cucaaguggc agaagaccaa gugggccgac cuccccccca ucaagaagaa cuucuacaag      600

gaguccaccg ccaccuccgc cauguccaag gucgaggccg acuccuggcg caaggagaac      660

uucaacauca ccugggacga ccucaaggac ggcgagaagc gccccauccc caaccccacc      720

ugcaccuucg acgacgccuu ccagugcuac cccgagguca uggagaacau caagaaggcc      780

ggcuuccaga agcccacccc cauccagucc caggccuggc ccaucguccu ccagggcauc      840

gaccucaucg gcgucgccca gaccggcacc ggcaagaccc ucugcuaccu caugcccggc      900

uucauccacc ucguccucca gcccucccuc aagggccagc gcaaccgccc cggcaugcuc      960

guccucaccc ccacccgcga gcucgcccuc caggucgagg gcgagugcug caaguacucc     1020

uacaagggcc uccgcuccgu cugcgucuac ggcggcggca accgcgacga gcagaucgag     1080

gagcucaaga agggcgucga caucaucauc gccacccccg gccgccucaa cgaccuccag     1140

auguccaacu ucgucaaccu caagaacauc accuaccucg uccucgacga ggccgacaag     1200

augcucgaca ugggcuucga gccccagauc augaagaucc uccucgacgu ccgccccgac     1260

cgccagaccg ucaugaccuc cgccaccugg ccccacuccg uccaccgccu cgcccagucc     1320

uaccucaagg agcccaugau cgucuacguc ggcacccucg accucgucgc cgucuccucc     1380

gucaagcaga acaucaucgu caccaccgag gaggagaagu ggucccacau gcagaccuuc     1440

cuccagucca uguccuccac cgacaagguc aucgucuucg ucucccgcaa ggccgucgcc     1500

gaccaccucu ccuccgaccu cauccucggc aacaucuccg ucgagucccu ccacggcgac     1560

cgcgagcagc gcgaccgcga gaaggcccuc gagaacuuca agaccggcaa gguccgcauc     1620

cucaucgcca ccgaccucgc cucccgcggc cucgacgucc acgacgucac ccacgucuac     1680

aacuucgacu ucccccgcaa caucgaggag uacguccacc gcaucggccg caccggccgc     1740

gccggccgca ccggcgucuc caucaccacc cucacccgca acgacuggcg cgucgccucc     1800

gagcucauca acauccucga gcgcgccaac caguccaucc ccgaggagcu cgucuccaug     1860

gccgagcgcu ucaaggccca ccagcagaag cgcgagaugg agcgcaagau ggagcgcccc     1920

cagggccgcc ccaagaaguu ccacuga                                         1947


<210>  1851
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HAGE__Homo_sapiens__CCDS4977.1

<400>  1851
augagccacc auggcggggc ccccaaggcu uccaccuggg uggucgcauc uagaagguca       60

aguacaguua gccgggcccc ugagcgccga ccagcggaag aacugaaccg uacuggaccg      120

gaagguuacu ccgugggcag agggggaagg uggcggggca cgucuaggcc cccugaggcu      180

guagccgcag gucacgagga gcucccacuu ugcuucgccc ugaaaucgca uuuugugggg      240

gcugucaucg gaagaggcgg cucaaagauu aaaaauauac agagcaccac aaacacuacc      300

auccaaauua uccaggagca gcccgaaagu uuggugaaga uuuucggguc caaagcaaug      360

cagacaaagg ccaaggcugu uaucgacaau uuugugaaaa aguuagagga aaacuauaau      420

ucugagugug gaauagauac cgccuuccaa ccuagcgucg guaaagacgg cuccacugau      480

aacaaugugg uagcggggga caggccacug aucgauuggg accagauucg ggaggaagga      540

cuaaaguggc agaaaacaaa gugggcagau cucccuccca ucaagaaaaa cuuuuacaag      600

gagucaaccg ccacgagugc uaugagcaaa guugaagccg acucuuggcg caaggagaau      660

uucaacauua cuugggauga ccugaaagau ggcgaaaagc gaccaauccc gaauccuacc      720

ugcacauuug acgaugcauu ccaguguuau cccgagguga uggagaacau uaaaaaggcu      780

gguuuucaaa agccaacucc cauacagucc caggccuggc cuaucguccu ucaggggauu      840

gaccugaucg gaguggcgca aaccggcaca ggcaaaaccu ugugcuaccu caugccaggg      900

uucauccacc uggugcugca gcccucacuc aagggacaga gaaauaggcc ggguauguua      960

guccugacgc cuacucggga acuugccuug caaguugagg gcgaauguug caaauauagc     1020

uacaaggggc ugcguagugu guguguauau ggaggcggua accgcgacga gcagauugaa     1080

gaguugaaaa agggggugga uauaaucauu gcaacacccg gcagacucaa ugaccugcag     1140

augucuaacu uugucaaccu uaagaauauc accuaccugg uguuggauga ggcugacaaa     1200

augcucgaua ugggauucga accacagaua augaagauuc uguuagacgu uaggccugau     1260

cggcaaacug ugaugacauc cgccaccugg ccccauagcg uccaccgacu ggcucagucg     1320

uaccucaaag agccaaugau cguguaugua ggcacgcuug accugguugc cgugucuucc     1380

gucaagcaga acaucauugu gaccacagaa gaggaaaaau ggucacacau gcagacuuuu     1440

cuacaaagua ugagcuccac cgauaagguc aucguguucg uuucucgcaa ggcaguggcc     1500

gaccaucuaa gcucagaucu gauucucggg aauauaagug uagagucccu gcacggagac     1560

agagagcaga gggaccggga aaaagcucuu gagaacuuca agacagguaa aguccgcauc     1620

cugauugcga cugauuuggc aagcagaggc cucgacgugc augauguuac ccacguguac     1680

aauuuugacu uccccaggaa caucgaagag uauguccacc guaucgggcg gacaggacga     1740

gccggcagaa ccgguguguc uauuacuacg cugacaagga augauuggcg cguagcuuca     1800

gaguuaauaa acauccugga acgggccaau cagaguauuc cugaggagcu agugagcaug     1860

gcagaaagau uuaaggccca ucagcaaaaa cgcgaaaugg agcgcaagau ggagcgacca     1920

caggggcggc cgaagaaauu ccacuga                                         1947


<210>  1852
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HAGE__Homo_sapiens__CCDS4977.1

<400>  1852
augagccacc acggcggcgc ccccaaggcc agcaccuggg ugguggccag cagaagaagc       60

agcaccguga gcagagcccc cgagagaaga cccgccgagg agcugaacag aaccggcccc      120

gagggcuaca gcgugggcag aggcggcaga uggagaggca ccagcagacc ccccgaggcc      180

guggccgccg gccacgagga gcugccccug ugcuucgccc ugaagagcca cuucgugggc      240

gccgugaucg gcagaggcgg cagcaagauc aagaacaucc agagcaccac caacaccacc      300

auccagauca uccaggagca gcccgagagc cuggugaaga ucuucggcag caaggccaug      360

cagaccaagg ccaaggccgu gaucgacaac uucgugaaga agcuggagga gaacuacaac      420

agcgagugcg gcaucgacac cgccuuccag cccagcgugg gcaaggacgg cagcaccgac      480

aacaacgugg uggccggcga cagaccccug aucgacuggg accagaucag agaggagggc      540

cugaaguggc agaagaccaa gugggccgac cugcccccca ucaagaagaa cuucuacaag      600

gagagcaccg ccaccagcgc caugagcaag guggaggccg acagcuggag aaaggagaac      660

uucaacauca ccugggacga ccugaaggac ggcgagaaga gacccauccc caaccccacc      720

ugcaccuucg acgacgccuu ccagugcuac cccgagguga uggagaacau caagaaggcc      780

ggcuuccaga agcccacccc cauccagagc caggccuggc ccaucgugcu gcagggcauc      840

gaccugaucg gcguggccca gaccggcacc ggcaagaccc ugugcuaccu gaugcccggc      900

uucauccacc uggugcugca gcccagccug aagggccaga gaaacagacc cggcaugcug      960

gugcugaccc ccaccagaga gcuggcccug cagguggagg gcgagugcug caaguacagc     1020

uacaagggcc ugagaagcgu gugcguguac ggcggcggca acagagacga gcagaucgag     1080

gagcugaaga agggcgugga caucaucauc gccacccccg gcagacugaa cgaccugcag     1140

augagcaacu ucgugaaccu gaagaacauc accuaccugg ugcuggacga ggccgacaag     1200

augcuggaca ugggcuucga gccccagauc augaagaucc ugcuggacgu gagacccgac     1260

agacagaccg ugaugaccag cgccaccugg ccccacagcg ugcacagacu ggcccagagc     1320

uaccugaagg agcccaugau cguguacgug ggcacccugg accugguggc cgugagcagc     1380

gugaagcaga acaucaucgu gaccaccgag gaggagaagu ggagccacau gcagaccuuc     1440

cugcagagca ugagcagcac cgacaaggug aucguguucg ugagcagaaa ggccguggcc     1500

gaccaccuga gcagcgaccu gauccugggc aacaucagcg uggagagccu gcacggcgac     1560

agagagcaga gagacagaga gaaggcccug gagaacuuca agaccggcaa ggugagaauc     1620

cugaucgcca ccgaccuggc cagcagaggc cuggacgugc acgacgugac ccacguguac     1680

aacuucgacu uccccagaaa caucgaggag uacgugcaca gaaucggcag aaccggcaga     1740

gccggcagaa ccggcgugag caucaccacc cugaccagaa acgacuggag aguggccagc     1800

gagcugauca acauccugga gagagccaac cagagcaucc ccgaggagcu ggugagcaug     1860

gccgagagau ucaaggccca ccagcagaag agagagaugg agagaaagau ggagagaccc     1920

cagggcagac ccaagaaguu ccacuga                                         1947


<210>  1853
<211>  1947
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HAGE__Homo_sapiens__CCDS4977.1

<400>  1853
augagccacc auggcggggc ccccaaggcu uccaccuggg uggucgccuc uagacggagc       60

uccacaguuu cucgcgcgcc ugagagacgg ccggcugaag aacugaaccg cacgggaccc      120

gaaggcuaca gcguggggag aggaggccgg uggcgcggga ccuccagacc ucccgaggcc      180

guggccgcug gacacgagga gcucccucug ugcuucgccc uuaaaucuca uuuugucggc      240

gcugugaucg gccgcggggg aagcaagauu aaaaauaucc aguccacaac caacacaacc      300

auucaaauca uucaggagca gcccgaaagc cugguuaaga ucuucggcuc uaaagccaug      360

cagacaaagg cgaaggccgu gaucgacaau uuugucaaaa agcucgagga aaacuauaau      420

uccgagugug ggauugauac cgcuuuccaa ccuagcgugg gaaaagacgg cucuacggau      480

aacaauguug uggccgggga ccggccgcug aucgauuggg accagauuag agaggaagga      540

cuuaaguggc agaaaaccaa gugggcugau cugcccccua ucaagaaaaa cuuuuacaag      600

gaguccacag ccaccagcgc gaugucuaaa gucgaagccg acuccuggcg gaaggagaau      660

uucaacauua caugggauga ccucaaagau ggcgaaaagc gccccauccc uaauccgacc      720

ugcacguuug acgaugcuuu ccaguguuau cccgagguga uggagaacau uaaaaaggcc      780

ggcuuucaaa agccuacacc cauccagagc caggcuuggc cuaucgugcu gcaggggauu      840

gaccugaucg gagucgccca aaccggcaca gggaaaaccc ucugcuaccu gaugcccgga      900

uucauucacc uuguucugca gcccucccuc aagggccaga gaaaucggcc ugggaugcug      960

gugcuuaccc cgacacgcga acuggcccuc caaguggagg gagaauguug caaauauucu     1020

uacaagggcc ugagaagcgu cuguguguau ggcgggggaa accgggacga gcagaucgag     1080

gaacugaaaa agggcguuga uauuaucauc gcuacgcccg ggagacucaa ugaccugcag     1140

auguccaacu uugugaaccu uaagaauauu accuaccugg uccucgauga ggcggacaaa     1200

augcuggaua ugggauucga accucagauc augaagauuc uucuggacgu gcgccccgau     1260

cggcaaacag uuaugaccag cgccacaugg ccucauucug ugcacagacu cgcucagucc     1320

uaccugaaag agcccaugau cgucuaugug ggcacccugg accucgucgc cgugagcucu     1380

guuaagcaga acauuaucgu gacgacagaa gaggaaaaau ggagccacau gcagaccuuu     1440

cugcaaucca ugucuagcac cgauaagguc aucguguucg uuucccgcaa ggccguggcu     1500

gaccaucuua gcucugaucu gauucucggg aauaucuccg ucgagagccu gcacggcgac     1560

cgggagcaga gagaccgcga aaaagcccuu gagaacuuca agacaggaaa agugcggauu     1620

cugaucgcga ccgaucucgc uucuagaggc cuggacgugc augauguuac acacgucuac     1680

aauuuugacu ucccgcgcaa cauugaagag uaugugcacc ggaucgggag aacgggacgc     1740

gccggccgga ccgggguguc cauuacaacc cugacaagaa augauuggcg ggucgccagc     1800

gagcucauca acauccugga acgcgcuaau caguccauuc cugaggaacu ugugucuaug     1860

gccgagagau uuaaggcuca ucagcaaaaa cgggaaaugg agagaaagau ggagcgcccc     1920

cagggacggc cuaagaaauu ccacuga                                         1947


<210>  1854
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hepsin__Homo_sapiens__B2ZDQ2

<400>  1854

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln 
        


<210>  1855
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  hepsin__Homo_sapiens__ACD02430

<400>  1855
auggcgcaga aggagggugg ccggacugug ccaugcugcu ccagacccaa gguggcagcu       60

cucacugcgg ggacccugcu acuucugaca gccaucgggg cggcauccug ggccauugug      120

gcuguucucc ucaggaguga ccaggagccg cuguacccag ugcaggucag cucugcggac      180

gcucggcuca uggucuuuga caagacggaa gggacguggc ggcugcugug cuccucgcgc      240

uccaacgcca ggguagccgg acucagcugc gaggagaugg gcuuccucag ggcacugacc      300

cacuccgagc uggacgugcg aacggcgggc gccaauggca cgucgggcuu cuucugugug      360

gacgagggga ggcugcccca cacccagagg cugcuggagg ucaucuccgu gugugauugc      420

cccagaggcc guuucuuggc cgccaucugc caagacugug gccgcaggaa gcugcccgug      480

gaccgcaucg ugggaggccg ggacaccagc uugggccggu ggccguggca agucagccuu      540

cgcuaugaug gagcacaccu cuguggggga ucccugcucu ccggggacug ggugcugaca      600

gccgcccacu gcuucccgga gcggaaccgg guccuguccc gauggcgagu guuugccggu      660

gccguggccc aggccucucc ccacggucug cagcuggggg ugcaggcugu ggucuaccac      720

gggggcuauc uucccuuucg ggaccccaac agcgaggaga acagcaacga uauugcccug      780

guccaccucu ccaguccccu gccccucaca gaauacaucc agccugugug ccucccagcu      840

gccggccagg cccuggugga uggcaagauc uguaccguga cgggcugggg caacacgcag      900

uacuauggcc aacaggccgg gguacuccag gaggcucgag uccccauaau cagcaaugau      960

gucugcaaug gcgcugacuu cuauggaaac cagaucaagc ccaagauguu cugugcuggc     1020

uaccccgagg guggcauuga ugccugccag ggcgacagcg guggucccuu ugugugugag     1080

gacagcaucu cucggacgcc acguuggcgg cuguguggca uugugaguug gggcacuggc     1140

ugugcccugg cccagaagcc aggcgucuac accaaaguca gugacuuccg ggaguggauc     1200

uuccaguga                                                             1209


<210>  1856
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       hepsin__Homo_sapiens__ACD02430

<400>  1856
auggcccaga aggagggcgg gcgcaccgug cccugcugca gccggccgaa ggucgccgcg       60

cugaccgccg gcacgcuccu gcugcucacc gccaucgggg ccgccuccug ggcgaucgug      120

gccgugcugc ugcgcagcga ccaggagccc cucuaccccg uccagguguc cagcgccgac      180

gcccggcuga ugguguucga caagaccgag ggcaccuggc gccugcucug cuccagccgg      240

uccaacgcgc gcgucgccgg gcugagcugc gaggagaugg gcuuccugcg ggcccucacg      300

cacuccgagc uggacgugcg caccgccggc gccaacggga ccagcggcuu cuucugcgug      360

gacgaggggc ggcugcccca cacccagcgc cuccuggagg ucaucuccgu gugcgacugc      420

ccgcggggcc gcuuccuggc ggccaucugc caggacugcg ggcggcgcaa gcuccccgug      480

gaccggaucg ucggcggccg cgacacgagc cuggggcggu ggcccuggca ggucucccug      540

cgcuacgacg gcgcccaccu cugcgggggc agccugcugu ccggcgacug ggugcucacc      600

gccgcccacu gcuuccccga gcggaaccgc gugcugagcc gguggcgcgu guucgcgggg      660

gccguggccc aggccucccc gcacggccug cagcucgggg uccaggccgu gguguaccac      720

ggcggguacc ugcccuuccg cgaccccaac agcgaggaga acuccaacga caucgcgcug      780

guccaccuca gcagcccccu gccgcugacc gaguacaucc agcccgugug ccuccccgcc      840

gccggccagg cccuggugga cggcaagauc ugcaccguca cggggugggg caacacccag      900

uacuacgggc agcaggccgg cgugcugcag gaggcgcggg uccccaucau cuccaacgac      960

gugugcaacg gggccgacuu cuacggcaac cagaucaagc cgaagauguu cugcgccggc     1020

uaccccgagg gcgggaucga cgccugccag ggggacagcg gcgggcccuu cgugugcgag     1080

gacuccauca gccgcacgcc ccgguggcgc cucugcggca ucgucuccug gggcaccggg     1140

ugcgcgcugg cccagaagcc gggcguguac accaagguga gcgacuuccg ggaguggauc     1200

uuccaguga                                                             1209


<210>  1857
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       hepsin__Homo_sapiens__ACD02430

<400>  1857
auggcccaga aggagggcgg ccgcaccguc cccugcugcu cccgccccaa ggucgccgcc       60

cucaccgccg gcacccuccu ccuccucacc gccaucggcg ccgccuccug ggccaucguc      120

gccguccucc uccgcuccga ccaggagccc cucuaccccg uccaggucuc cuccgccgac      180

gcccgccuca uggucuucga caagaccgag ggcaccuggc gccuccucug cuccucccgc      240

uccaacgccc gcgucgccgg ccucuccugc gaggagaugg gcuuccuccg cgcccucacc      300

cacuccgagc ucgacguccg caccgccggc gccaacggca ccuccggcuu cuucugcguc      360

gacgagggcc gccuccccca cacccagcgc cuccucgagg ucaucuccgu cugcgacugc      420

ccccgcggcc gcuuccucgc cgccaucugc caggacugcg gccgccgcaa gcuccccguc      480

gaccgcaucg ucggcggccg cgacaccucc cucggccgcu ggcccuggca ggucucccuc      540

cgcuacgacg gcgcccaccu cugcggcggc ucccuccucu ccggcgacug gguccucacc      600

gccgcccacu gcuuccccga gcgcaaccgc guccucuccc gcuggcgcgu cuucgccggc      660

gccgucgccc aggccucccc ccacggccuc cagcucggcg uccaggccgu cgucuaccac      720

ggcggcuacc uccccuuccg cgaccccaac uccgaggaga acuccaacga caucgcccuc      780

guccaccucu ccuccccccu cccccucacc gaguacaucc agcccgucug ccuccccgcc      840

gccggccagg cccucgucga cggcaagauc ugcaccguca ccggcugggg caacacccag      900

uacuacggcc agcaggccgg cguccuccag gaggcccgcg uccccaucau cuccaacgac      960

gucugcaacg gcgccgacuu cuacggcaac cagaucaagc ccaagauguu cugcgccggc     1020

uaccccgagg gcggcaucga cgccugccag ggcgacuccg gcggccccuu cgucugcgag     1080

gacuccaucu cccgcacccc ccgcuggcgc cucugcggca ucgucuccug gggcaccggc     1140

ugcgcccucg cccagaagcc cggcgucuac accaaggucu ccgacuuccg cgaguggauc     1200

uuccaguga                                                             1209


<210>  1858
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       hepsin__Homo_sapiens__ACD02430

<400>  1858
auggcccaga aggagggcgg gagaaccgug cccugcugua gcaggccuaa agucgcugca       60

cugacagccg gaacucuccu ucuguugacg gcgaucggug cugccuccug ggcaauuguu      120

gccguguuac ugcggucuga ccaagaacca cuauacccgg uacagguguc aagugcugau      180

gcacgccuca uggucuucga caagaccgag ggcacauggc gacugcuuug cagcucccgu      240

ucuaacgcca gaguggcugg gcugucgugu gaagagaugg gauuuuugag ggcccucacu      300

cacucagaac uggauguucg gaccgcgggc gcaaauggua caagcggguu cuuuugcgug      360

gacgagggac gccugcccca uacccagaga cucuuagagg ucauaagugu gugugauugc      420

ccuaggggcc gguuccuggc cgcuaucugu caggacugcg gccgccgaaa acuuccagua      480

gauagaauug uugggggaag ggacacuucc uugggucggu ggcccuggca agugucucug      540

cguuaugaug gcgcccaccu auguggggga agccuccugu ccggcgacug gguccuuaca      600

gcagcucauu gcuuuccuga acgcaacaga gugcugucaa gguggcgggu guucgccggu      660

gcggucgccc aggcaagucc acacggguug cagcucggag uucaggcugu gguauaccau      720

ggcggcuauc ugcccuuucg agauccuaau agcgaggaaa acucuaauga caucgccuua      780

gugcaccugu ccucaccacu cccgcuuacc gaguacauuc aacccgucug ucugccugcu      840

gccgggcagg cauuggugga uggaaagauc ugcacgguua cugguugggg caacacccag      900

uauuacgggc agcaagccgg agugcuacag gaggcucgcg ucccaauaau cagcaaugac      960

gugugcaacg gcgcggacuu cuaugguaau cagauuaaac ccaagauguu uugugcaggg     1020

uacccugaag gcggaaucga ugccugccaa ggcgacagug ggggaccauu cguaugugag     1080

gauucuauuu ccagaacacc cagguggcgg cugugcggua ucguuagcug gggcacuggg     1140

ugugcucucg cccagaagcc gggaguguac accaaagucu cggacuuucg cgaauggaua     1200

uuccaguga                                                             1209


<210>  1859
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       hepsin__Homo_sapiens__ACD02430

<400>  1859
auggcccaga aggagggcgg cagaaccgug cccugcugca gcagacccaa gguggccgcc       60

cugaccgccg gcacccugcu gcugcugacc gccaucggcg ccgccagcug ggccaucgug      120

gccgugcugc ugagaagcga ccaggagccc cuguaccccg ugcaggugag cagcgccgac      180

gccagacuga ugguguucga caagaccgag ggcaccugga gacugcugug cagcagcaga      240

agcaacgcca gaguggccgg ccugagcugc gaggagaugg gcuuccugag agcccugacc      300

cacagcgagc uggacgugag aaccgccggc gccaacggca ccagcggcuu cuucugcgug      360

gacgagggca gacugcccca cacccagaga cugcuggagg ugaucagcgu gugcgacugc      420

cccagaggca gauuccuggc cgccaucugc caggacugcg gcagaagaaa gcugcccgug      480

gacagaaucg ugggcggcag agacaccagc cugggcagau ggcccuggca ggugagccug      540

agauacgacg gcgcccaccu gugcggcggc agccugcuga gcggcgacug ggugcugacc      600

gccgcccacu gcuuccccga gagaaacaga gugcugagca gauggagagu guucgccggc      660

gccguggccc aggccagccc ccacggccug cagcugggcg ugcaggccgu gguguaccac      720

ggcggcuacc ugcccuucag agaccccaac agcgaggaga acagcaacga caucgcccug      780

gugcaccuga gcagcccccu gccccugacc gaguacaucc agcccgugug ccugcccgcc      840

gccggccagg cccuggugga cggcaagauc ugcaccguga ccggcugggg caacacccag      900

uacuacggcc agcaggccgg cgugcugcag gaggccagag ugcccaucau cagcaacgac      960

gugugcaacg gcgccgacuu cuacggcaac cagaucaagc ccaagauguu cugcgccggc     1020

uaccccgagg gcggcaucga cgccugccag ggcgacagcg gcggccccuu cgugugcgag     1080

gacagcauca gcagaacccc cagauggaga cugugcggca ucgugagcug gggcaccggc     1140

ugcgcccugg cccagaagcc cggcguguac accaagguga gcgacuucag agaguggauc     1200

uuccaguga                                                             1209


<210>  1860
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       hepsin__Homo_sapiens__ACD02430

<400>  1860
auggcccaga aggagggcgg gagaaccgug cccugcugua gccggccuaa agucgcugcc       60

cugacagcgg gaacgcuccu gcuucugacc gcuaucggcg ccgccuccug ggcuauuguu      120

gccgugcucc ugcgcucuga ccaagaaccg cuuuaccccg ugcaggucag cuccgcugau      180

gccagacuga ugguguucga caagacagag gggaccuggc ggcuccugug cucuagccgc      240

uccaacgcga gaguugccgg acugucuugu gaagagaugg gcuuucuccg ggcucugaca      300

cacagcgaac uugaugugcg caccgccggg gcuaauggaa cauccggcuu cuuuugcguc      360

gacgagggca gacugccuca uacccagcgg cuccuggagg ugaucagcgu uugugauugc      420

ccccgcggga gauuccuugc cgcgauuugu caggacugcg gacggcgcaa acugccugug      480

gauagaaucg ucggcgggcg ggacacgucu cucggacgcu ggcccuggca agugucccug      540

agauaugaug gcgcccaccu guguggggga agccuccugu cuggcgacug ggugcuuacc      600

gcugcccauu gcuuuccuga acggaacaga guccuguccc gcuggcgggu uuucgcuggc      660

gccguggccc aggcuagccc gcacgggcuc cagcugggag ugcaggcggu cguguaccau      720

ggcggguauc uucccuuuag agauccuaau ucugaggaaa acuccaauga cauugcccug      780

guucaccuca gcucuccccu gccucugaca gaguacaucc aacccgugug ucucccggcu      840

gccggacagg cccuggucga uggcaagauc ugcaccguga cagggugggg aaacacccag      900

uauuacggcc agcaagcugg cguucuucag gaggcccgcg ugccuauuau cuccaaugac      960

gucugcaacg gggcggacuu cuauggaaau cagauuaaac ccaagauguu uugugcuggc     1020

uacccugaag ggggaaucga ugccugccaa ggcgacagcg ggggccccuu cgugugugag     1080

gauuccauua gccggacgcc cagauggcgc cugugcggaa ucgucucuug gggcacaggg     1140

ugugcccucg cucagaagcc uggaguguac accaaaguuu ccgacuuucg ggaauggauu     1200

uuccaguga                                                             1209


<210>  1861
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hepsin__Homo_sapiens__P05981

<400>  1861

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210>  1862
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  hepsin__Homo_sapiens__AAA36013

<400>  1862
auggcgcaga aggagggugg ccggacugug ccaugcugcu ccagacccaa gguggcagcu       60

cucacugcgg ggacccugcu acuucugaca gccaucgggg cggcauccug ggccauugug      120

gcuguucucc ucaggaguga ccaggagccg cuguacccag ugcaggucag cucugcggac      180

gcucggcuca uggucuuuga caagacggaa gggacguggc ggcugcugug cuccucgcgc      240

uccaacgcca ggguagccgg acucagcugc gaggagaugg gcuuccucag ggcacugacc      300

cacuccgagc uggacgugcg aacggcgggc gccaauggca cgucgggcuu cuucugugug      360

gacgagggga ggcugcccca cacccagagg cugcuggagg ucaucuccgu gugugauugc      420

cccagaggcc guuucuuggc cgccaucugc caagacugug gccgcaggaa gcugcccgug      480

gaccgcaucg ugggaggccg ggacaccagc uugggccggu ggccguggca agucagccuu      540

cgcuaugaug gagcacaccu cuguggggga ucccugcucu ccggggacug ggugcugaca      600

gccgcccacu gcuucccgga gcggaaccgg guccuguccc gauggcgagu guuugccggu      660

gccguggccc aggccucucc ccacggucug cagcuggggg ugcaggcugu ggucuaccac      720

gggggcuauc uucccuuucg ggaccccaac agcgaggaga acagcaacga uauugcccug      780

guccaccucu ccaguccccu gccccucaca gaauacaucc agccugugug ccucccagcu      840

gccggccagg cccuggugga uggcaagauc uguaccguga cgggcugggg caacacgcag      900

uacuauggcc aacaggccgg gguacuccag gaggcucgag uccccauaau cagcaaugau      960

gucugcaaug gcgcugacuu cuauggaaac cagaucaagc ccaagauguu cugugcuggc     1020

uaccccgagg guggcauuga ugccugccag ggcgacagcg guggucccuu ugugugugag     1080

gacagcaucu cucggacgcc acguuggcgg cuguguggca uugugaguug gggcacuggc     1140

ugugcccugg cccagaagcc aggcgucuac accaaaguca gugacuuccg ggaguggauc     1200

uuccaggcca uaaagacuca cuccgaagcc agcggcaugg ugacccagcu cuga           1254


<210>  1863
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       hepsin__Homo_sapiens__AAA36013

<400>  1863
auggcccaga aggagggcgg gcgcaccgug cccugcugca gccggccgaa ggucgccgcg       60

cugaccgccg gcacgcuccu gcugcucacc gccaucgggg ccgccuccug ggcgaucgug      120

gccgugcugc ugcgcagcga ccaggagccc cucuaccccg uccagguguc cagcgccgac      180

gcccggcuga ugguguucga caagaccgag ggcaccuggc gccugcucug cuccagccgg      240

uccaacgcgc gcgucgccgg gcugagcugc gaggagaugg gcuuccugcg ggcccucacg      300

cacuccgagc uggacgugcg caccgccggc gccaacggga ccagcggcuu cuucugcgug      360

gacgaggggc ggcugcccca cacccagcgc cuccuggagg ucaucuccgu gugcgacugc      420

ccgcggggcc gcuuccuggc ggccaucugc caggacugcg ggcggcgcaa gcuccccgug      480

gaccggaucg ucggcggccg cgacacgagc cuggggcggu ggcccuggca ggucucccug      540

cgcuacgacg gcgcccaccu cugcgggggc agccugcugu ccggcgacug ggugcucacc      600

gccgcccacu gcuuccccga gcggaaccgc gugcugagcc gguggcgcgu guucgcgggg      660

gccguggccc aggccucccc gcacggccug cagcucgggg uccaggccgu gguguaccac      720

ggcggguacc ugcccuuccg cgaccccaac agcgaggaga acuccaacga caucgcgcug      780

guccaccuca gcagcccccu gccgcugacc gaguacaucc agcccgugug ccuccccgcc      840

gccggccagg cccuggugga cggcaagauc ugcaccguca cggggugggg caacacccag      900

uacuacgggc agcaggccgg cgugcugcag gaggcgcggg uccccaucau cuccaacgac      960

gugugcaacg gggccgacuu cuacggcaac cagaucaagc cgaagauguu cugcgccggc     1020

uaccccgagg gcgggaucga cgccugccag ggggacagcg gcgggcccuu cgugugcgag     1080

gacuccauca gccgcacgcc ccgguggcgc cucugcggca ucgucuccug gggcaccggg     1140

ugcgcgcugg cccagaagcc gggcguguac accaagguga gcgacuuccg ggaguggauc     1200

uuccaggcca ucaagaccca cuccgaggcc agcgggaugg ucacccagcu guga           1254


<210>  1864
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       hepsin__Homo_sapiens__AAA36013

<400>  1864
auggcccaga aggagggcgg ccgcaccguc cccugcugcu cccgccccaa ggucgccgcc       60

cucaccgccg gcacccuccu ccuccucacc gccaucggcg ccgccuccug ggccaucguc      120

gccguccucc uccgcuccga ccaggagccc cucuaccccg uccaggucuc cuccgccgac      180

gcccgccuca uggucuucga caagaccgag ggcaccuggc gccuccucug cuccucccgc      240

uccaacgccc gcgucgccgg ccucuccugc gaggagaugg gcuuccuccg cgcccucacc      300

cacuccgagc ucgacguccg caccgccggc gccaacggca ccuccggcuu cuucugcguc      360

gacgagggcc gccuccccca cacccagcgc cuccucgagg ucaucuccgu cugcgacugc      420

ccccgcggcc gcuuccucgc cgccaucugc caggacugcg gccgccgcaa gcuccccguc      480

gaccgcaucg ucggcggccg cgacaccucc cucggccgcu ggcccuggca ggucucccuc      540

cgcuacgacg gcgcccaccu cugcggcggc ucccuccucu ccggcgacug gguccucacc      600

gccgcccacu gcuuccccga gcgcaaccgc guccucuccc gcuggcgcgu cuucgccggc      660

gccgucgccc aggccucccc ccacggccuc cagcucggcg uccaggccgu cgucuaccac      720

ggcggcuacc uccccuuccg cgaccccaac uccgaggaga acuccaacga caucgcccuc      780

guccaccucu ccuccccccu cccccucacc gaguacaucc agcccgucug ccuccccgcc      840

gccggccagg cccucgucga cggcaagauc ugcaccguca ccggcugggg caacacccag      900

uacuacggcc agcaggccgg cguccuccag gaggcccgcg uccccaucau cuccaacgac      960

gucugcaacg gcgccgacuu cuacggcaac cagaucaagc ccaagauguu cugcgccggc     1020

uaccccgagg gcggcaucga cgccugccag ggcgacuccg gcggccccuu cgucugcgag     1080

gacuccaucu cccgcacccc ccgcuggcgc cucugcggca ucgucuccug gggcaccggc     1140

ugcgcccucg cccagaagcc cggcgucuac accaaggucu ccgacuuccg cgaguggauc     1200

uuccaggcca ucaagaccca cuccgaggcc uccggcaugg ucacccagcu cuga           1254


<210>  1865
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       hepsin__Homo_sapiens__AAA36013

<400>  1865
auggcccaga aggagggcgg gagaaccgug cccugcugua gcaggccuaa agucgcugca       60

cugacagccg gaacucuccu ucuguugacg gcgaucggug cugccuccug ggcaauuguu      120

gccguguuac ugcggucuga ccaagaacca cuauacccgg uacagguguc aagugcugau      180

gcacgccuca uggucuucga caagaccgag ggcacauggc gacugcuuug cagcucccgu      240

ucuaacgcca gaguggcugg gcugucgugu gaagagaugg gauuuuugag ggcccucacu      300

cacucagaac uggauguucg gaccgcgggc gcaaauggua caagcggguu cuuuugcgug      360

gacgagggac gccugcccca uacccagaga cucuuagagg ucauaagugu gugugauugc      420

ccuaggggcc gguuccuggc cgcuaucugu caggacugcg gccgccgaaa acuuccagua      480

gauagaauug uugggggaag ggacacuucc uugggucggu ggcccuggca agugucucug      540

cguuaugaug gcgcccaccu auguggggga agccuccugu ccggcgacug gguccuuaca      600

gcagcucauu gcuuuccuga acgcaacaga gugcugucaa gguggcgggu guucgccggu      660

gcggucgccc aggcaagucc acacggguug cagcucggag uucaggcugu gguauaccau      720

ggcggcuauc ugcccuuucg agauccuaau agcgaggaaa acucuaauga caucgccuua      780

gugcaccugu ccucaccacu cccgcuuacc gaguacauuc aacccgucug ucugccugcu      840

gccgggcagg cauuggugga uggaaagauc ugcacgguua cugguugggg caacacccag      900

uauuacgggc agcaagccgg agugcuacag gaggcucgcg ucccaauaau cagcaaugac      960

gugugcaacg gcgcggacuu cuaugguaau cagauuaaac ccaagauguu uugugcaggg     1020

uacccugaag gcggaaucga ugccugccaa ggcgacagug ggggaccauu cguaugugag     1080

gauucuauuu ccagaacacc cagguggcgg cugugcggua ucguuagcug gggcacuggg     1140

ugugcucucg cccagaagcc gggaguguac accaaagucu cggacuuucg cgaauggaua     1200

uuccaggcaa uuaagacaca cucugaggcc uccggcaugg ugacccagcu guga           1254


<210>  1866
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       hepsin__Homo_sapiens__AAA36013

<400>  1866
auggcccaga aggagggcgg cagaaccgug cccugcugca gcagacccaa gguggccgcc       60

cugaccgccg gcacccugcu gcugcugacc gccaucggcg ccgccagcug ggccaucgug      120

gccgugcugc ugagaagcga ccaggagccc cuguaccccg ugcaggugag cagcgccgac      180

gccagacuga ugguguucga caagaccgag ggcaccugga gacugcugug cagcagcaga      240

agcaacgcca gaguggccgg ccugagcugc gaggagaugg gcuuccugag agcccugacc      300

cacagcgagc uggacgugag aaccgccggc gccaacggca ccagcggcuu cuucugcgug      360

gacgagggca gacugcccca cacccagaga cugcuggagg ugaucagcgu gugcgacugc      420

cccagaggca gauuccuggc cgccaucugc caggacugcg gcagaagaaa gcugcccgug      480

gacagaaucg ugggcggcag agacaccagc cugggcagau ggcccuggca ggugagccug      540

agauacgacg gcgcccaccu gugcggcggc agccugcuga gcggcgacug ggugcugacc      600

gccgcccacu gcuuccccga gagaaacaga gugcugagca gauggagagu guucgccggc      660

gccguggccc aggccagccc ccacggccug cagcugggcg ugcaggccgu gguguaccac      720

ggcggcuacc ugcccuucag agaccccaac agcgaggaga acagcaacga caucgcccug      780

gugcaccuga gcagcccccu gccccugacc gaguacaucc agcccgugug ccugcccgcc      840

gccggccagg cccuggugga cggcaagauc ugcaccguga ccggcugggg caacacccag      900

uacuacggcc agcaggccgg cgugcugcag gaggccagag ugcccaucau cagcaacgac      960

gugugcaacg gcgccgacuu cuacggcaac cagaucaagc ccaagauguu cugcgccggc     1020

uaccccgagg gcggcaucga cgccugccag ggcgacagcg gcggccccuu cgugugcgag     1080

gacagcauca gcagaacccc cagauggaga cugugcggca ucgugagcug gggcaccggc     1140

ugcgcccugg cccagaagcc cggcguguac accaagguga gcgacuucag agaguggauc     1200

uuccaggcca ucaagaccca cagcgaggcc agcggcaugg ugacccagcu guga           1254


<210>  1867
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       hepsin__Homo_sapiens__AAA36013

<400>  1867
auggcccaga aggagggcgg gagaaccgug cccugcugua gccggccuaa agucgcugcc       60

cugacagcgg gaacgcuccu gcuucugacc gcuaucggcg ccgccuccug ggcuauuguu      120

gccgugcucc ugcgcucuga ccaagaaccg cuuuaccccg ugcaggucag cuccgcugau      180

gccagacuga ugguguucga caagacagag gggaccuggc ggcuccugug cucuagccgc      240

uccaacgcga gaguugccgg acugucuugu gaagagaugg gcuuucuccg ggcucugaca      300

cacagcgaac uugaugugcg caccgccggg gcuaauggaa cauccggcuu cuuuugcguc      360

gacgagggca gacugccuca uacccagcgg cuccuggagg ugaucagcgu uugugauugc      420

ccccgcggga gauuccuugc cgcgauuugu caggacugcg gacggcgcaa acugccugug      480

gauagaaucg ucggcgggcg ggacacgucu cucggacgcu ggcccuggca agugucccug      540

agauaugaug gcgcccaccu guguggggga agccuccugu cuggcgacug ggugcuuacc      600

gcugcccauu gcuuuccuga acggaacaga guccuguccc gcuggcgggu uuucgcuggc      660

gccguggccc aggcuagccc gcacgggcuc cagcugggag ugcaggcggu cguguaccau      720

ggcggguauc uucccuuuag agauccuaau ucugaggaaa acuccaauga cauugcccug      780

guucaccuca gcucuccccu gccucugaca gaguacaucc aacccgugug ucucccggcu      840

gccggacagg cccuggucga uggcaagauc ugcaccguga cagggugggg aaacacccag      900

uauuacggcc agcaagcugg cguucuucag gaggcccgcg ugccuauuau cuccaaugac      960

gucugcaacg gggcggacuu cuauggaaau cagauuaaac ccaagauguu uugugcuggc     1020

uacccugaag ggggaaucga ugccugccaa ggcgacagcg ggggccccuu cgugugugag     1080

gauuccauua gccggacgcc cagauggcgc cugugcggaa ucgucucuug gggcacaggg     1140

ugugcccucg cucagaagcc uggaguguac accaaaguuu ccgacuuucg ggaauggauu     1200

uuccaggcca ucaagacaca cagcgaggcu ucuggcaugg ugacccagcu guga           1254


<210>  1868
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__B4DTR1

<400>  1868

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Asp Asn Tyr Leu Ser Thr Asp Val 
            20                  25                  30          


Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala 
        35                  40                  45              


Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg 
    50                  55                  60                  


Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val 
65                  70                  75                  80  


Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly 
                85                  90                  95      


Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn 
            100                 105                 110         


Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu 
        115                 120                 125             


Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro 
    130                 135                 140                 


Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu 
145                 150                 155                 160 


His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp 
                165                 170                 175     


Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile 
            180                 185                 190         


His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln 
        195                 200                 205             


Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro 
    210                 215                 220                 


Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala 
225                 230                 235                 240 


Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser 
                245                 250                 255     


Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln 
            260                 265                 270         


Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His 
        275                 280                 285             


Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu 
    290                 295                 300                 


Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys 
305                 310                 315                 320 


Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro 
                325                 330                 335     


Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile 
            340                 345                 350         


Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala 
        355                 360                 365             


Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly 
    370                 375                 380                 


Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys 
385                 390                 395                 400 


Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln 
                405                 410                 415     


Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn 
            420                 425                 430         


Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys 
        435                 440                 445             


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile 
    450                 455                 460                 


Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg 
465                 470                 475                 480 


Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
                485                 490                 495     


Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile 
            500                 505                 510         


Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly 
        515                 520                 525             


Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser Gln 
    530                 535                 540                 


Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr Leu 
545                 550                 555                 560 


Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                565                 570                 575     


Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala Arg 
            580                 585                 590         


Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys Val 
        595                 600                 605             


Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr 
    610                 615                 620                 


His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met 
625                 630                 635                 640 


Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile Pro 
                645                 650                 655     


Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr 
            660                 665                 670         


Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser Glu 
        675                 680                 685             


Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met Ala 
    690                 695                 700                 


Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly Pro 
705                 710                 715                 720 


Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp Asp 
                725                 730                 735     


Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln Gln 
            740                 745                 750         


Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met Val His 
        755                 760                 765             


His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp Leu Thr 
    770                 775                 780                 


Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro Leu Ala 
785                 790                 795                 800 


Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu Gly Met 
                805                 810                 815     


Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro Ser Pro 
            820                 825                 830         


Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser Glu Thr 
        835                 840                 845             


Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr Val 
    850                 855                 860                 


Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly Pro 
865                 870                 875                 880 


Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys Thr 
                885                 890                 895     


Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe Gly 
            900                 905                 910         


Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala Ala 
        915                 920                 925             


Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp Asn Leu 
    930                 935                 940                 


Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro Ser Thr 
945                 950                 955                 960 


Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly Leu Asp 
                965                 970                 975     


Val Pro Val 
            


<210>  1869
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__BAG62073

<400>  1869
auggagcugg cggccuugug ccgcuggggg cuccuccucg cccucuugcc ccccggagcc       60

gcgagcaccc aagacaacua ccuuucuacg gacgugggau ccugcacccu cgucugcccc      120

cugcacaacc aagaggugac agcagaggau ggaacacagc ggugugagaa gugcagcaag      180

cccugugccc gagugugcua uggucugggc auggagcacu ugcgagaggu gagggcaguu      240

accagugcca auauccagga guuugcuggc ugcaagaaga ucuuugggag ccuggcauuu      300

cugccggaga gcuuugaugg ggacccagcc uccaacacug ccccgcucca gccagagcag      360

cuccaagugu uugagacucu ggaagagauc acagguuacc uauacaucuc agcauggccg      420

gacagccugc cugaccucag cgucuuccag aaccugcaag uaauccgggg acgaauucug      480

cacaauggcg ccuacucgcu gacccugcaa gggcugggca ucagcuggcu ggggcugcgc      540

ucacugaggg aacugggcag uggacuggcc cucauccacc auaacaccca ccucugcuuc      600

gugcacacgg ugcccuggga ccagcucuuu cggaacccgc accaagcucu gcuccacacu      660

gccaaccggc cagaggacga gugugugggc gagggccugg ccugccacca gcugugcgcc      720

cgagggcacu gcuggggucc agggcccacc caguguguca acugcagcca guuccuucgg      780

ggccaggagu gcguggagga augccgagua cugcaggggc uccccaggga guaugugaau      840

gccaggcacu guuugccgug ccacccugag ugucagcccc agaauggcuc agugaccugu      900

uuuggaccgg aggcugacca guguguggcc ugugcccacu auaaggaccc ucccuucugc      960

guggcccgcu gccccagcgg ugugaaaccu gaccucuccu acaugcccau cuggaaguuu     1020

ccagaugagg agggcgcaug ccagccuugc cccaucaacu gcacccacuc cuguguggac     1080

cuggaugaca agggcugccc cgccgagcag agagccagcc cucugacguc caucaucucu     1140

gcggugguug gcauucugcu ggucgugguc uugggggugg ucuuugggau ccucaucaag     1200

cgacggcagc agaagauccg gaaguacacg augcggagac ugcugcagga aacggagcug     1260

guggagccgc ugacaccuag cggagcgaug cccaaccagg cgcagaugcg gauccugaaa     1320

gagacggagc ugaggaaggu gaaggugcuu ggaucuggcg cuuuuggcac agucuacaag     1380

ggcaucugga ucccugaugg ggagaaugug aaaauuccag uggccaucaa aguguugagg     1440

gaaaacacau cccccaaagc caacaaagaa aucuuagacg aagcauacgu gauggcuggu     1500

gugggcuccc cauaugucuc ccgccuucug ggcaucugcc ugacauccac ggugcagcug     1560

gugacacagc uuaugcccua uggcugccuc uuagaccaug uccgggaaaa ccgcggacgc     1620

cugggcuccc aggaccugcu gaacuggugu augcagauug ccaaggggau gagcuaccug     1680

gaggaugugc ggcucguaca cagggacuug gccgcucgga acgugcuggu caagaguccc     1740

aaccauguca aaauuacaga cuucgggcug gcucggcugc uggacauuga cgagacagag     1800

uaccaugcag augggggcaa ggugcccauc aaguggaugg cgcuggaguc cauucuccgc     1860

cggcgguuca cccaccagag ugaugugugg aguuauggug ugacugugug ggagcugaug     1920

acuuuugggg ccaaaccuua cgaugggauc ccagcccggg agaucccuga ccugcuggaa     1980

aagggggagc ggcugcccca gccccccauc ugcaccauug augucuacau gaucaugguc     2040

aaauguugga ugauugacuc ugaaugucgg ccaagauucc gggaguuggu gucugaauuc     2100

ucccgcaugg ccagggaccc ccagcgcuuu guggucaucc agaaugagga cuugggccca     2160

gccagucccu uggacagcac cuucuaccgc ucacugcugg aggacgauga caugggggac     2220

cugguggaug cugaggagua ucugguaccc cagcagggcu ucuucugucc agacccugcc     2280

ccgggcgcug ggggcauggu ccaccacagg caccgcagcu caucuaccag gaguggcggu     2340

ggggaccuga cacuagggcu ggagcccucu gaagaggagg cccccagguc uccacuggca     2400

cccuccgaag gggcuggcuc cgauguauuu gauggugacc ugggaauggg ggcagccaag     2460

gggcugcaaa gccuccccac acaugacccc agcccucuac agcgguacag ugaggacccc     2520

acaguacccc ugcccucuga gacugauggc uacguugccc cccugaccug cagcccccag     2580

ccugaauaug ugaaccagcc agauguucgg ccccagcccc cuucgccccg agagggcccu     2640

cugccugcug cccgaccugc uggugccacu cuggaaaggc ccaagacucu cuccccaggg     2700

aagaaugggg ucgucaaaga cguuuuugcc uuugggggug ccguggagaa ccccgaguac     2760

uugacacccc agggaggagc ugccccucag ccccacccuc cuccugccuu cagcccagcc     2820

uucgacaacc ucuauuacug ggaccaggac ccaccagagc ggggggcucc acccagcacc     2880

uucaaaggga caccuacggc agagaaccca gaguaccugg gucuggacgu gccaguguga     2940


<210>  1870
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Her2/neu__Homo_sapiens__BAG62073

<400>  1870
auggagcugg ccgcccucug ccgcuggggc cugcugcucg cgcugcugcc cccgggggcc       60

gccagcaccc aggacaacua ccucuccacc gacgugggca gcugcacgcu ggucugcccc      120

cugcacaacc aggaggugac cgccgaggac gggacccagc ggugcgagaa gugcuccaag      180

cccugcgccc gcgugugcua cggccucggg auggagcacc uccgggaggu ccgcgcggug      240

accagcgcca acauccagga guucgccggc ugcaagaaga ucuucggcuc ccuggccuuc      300

cugcccgaga gcuucgacgg ggacccggcg uccaacacgg cgccccugca gcccgagcag      360

cuccaggugu ucgagacccu ggaggagauc accggcuacc uguacaucag cgccuggccc      420

gacucccugc cggaccucag cgucuuccag aaccuccagg ugauccgggg gcgcauccug      480

cacaacggcg ccuacucccu gacccugcag gggcugggca ucagcuggcu cggccugcgg      540

ucccugcgcg agcucgggag cggccuggcc cugauccacc acaacacgca ccucugcuuc      600

gugcacaccg uccccuggga ccagcuguuc cggaaccccc accaggcccu gcuccacacc      660

gccaaccgcc ccgaggacga gugcgugggg gagggccugg ccugccacca gcugugcgcc      720

cggggccacu gcugggggcc gggccccacc cagugcguga acugcuccca guuccuccgc      780

gggcaggagu gcgucgagga gugccgggug cugcagggcc ugccccgcga guacgugaac      840

gcccggcacu gccuccccug ccacccggag ugccagcccc agaacgggag cgucacgugc      900

uucggccccg aggcggacca gugcguggcc ugcgcccacu acaaggaccc gcccuucugc      960

guggcccgcu gccccuccgg cgucaagccc gaccugagcu acaugcccau cuggaaguuc     1020

cccgacgagg agggggccug ccagcccugc cccaucaacu gcacccacuc cugcguggac     1080

cuggacgaca agggcugccc cgcggagcag cgggccagcc cgcucaccag caucaucucc     1140

gccguggucg ggauccugcu gguggugguc cucggcgugg ucuucgggau ccugaucaag     1200

cgccggcagc agaagauccg caaguacacc augcggcgcc ugcuccagga gacggagcug     1260

guggagcccc ugacccccag cggcgccaug ccgaaccagg cccagaugcg cauccugaag     1320

gagaccgagc uccggaaggu gaagguccug ggcuccgggg cguucggcac cguguacaag     1380

gggaucugga uccccgacgg cgagaacgug aagauccccg ucgccaucaa ggugcugcgc     1440

gagaacacga gccccaaggc caacaaggag auccucgacg aggccuacgu gauggcgggg     1500

gucggcuccc cguacgugag ccggcugcug ggcaucugcc ucaccuccac cgugcagcug     1560

gucacccagc ugaugcccua cgggugccuc cuggaccacg ugcgcgagaa ccggggccgc     1620

cuggggagcc aggaccuccu gaacuggugc augcagaucg ccaagggcau guccuaccug     1680

gaggacgugc ggcucgucca ccgcgaccug gccgcccgga acgugcuggu caagagcccc     1740

aaccacguga agaucacgga cuucggccuc gcccgccugc uggacaucga cgagaccgag     1800

uaccacgcgg acgggggcaa ggugcccauc aaguggaugg cccucgaguc cauccugcgg     1860

cgccgguuca cccaccagag cgacgugugg uccuacgggg ucaccgugug ggagcugaug     1920

acguucggcg ccaagccgua cgacgggauc cccgcccgcg agauccccga ccuccuggag     1980

aagggcgagc ggcugcccca gccgcccauc ugcaccaucg acguguacau gaucaugguc     2040

aagugcugga ugaucgacag cgagugccgc ccccgguucc gcgagcucgu guccgaguuc     2100

agccggaugg cccgcgaccc ccagcgcuuc guggucaucc agaacgagga ccugggcccg     2160

gcgagccccc uggacuccac cuucuaccgg ucccuccugg aggacgacga caugggggac     2220

cugguggacg ccgaggagua ccucgugccc cagcagggcu ucuucugccc cgacccggcc     2280

cccggggccg gcgggauggu ccaccaccgc caccggagca gcuccacccg cagcggcggc     2340

ggggaccuga cgcugggccu cgagcccucc gaggaggagg cgccccggag cccgcuggcc     2400

cccuccgagg gggccggcag cgacguguuc gacggggacc ugggcauggg cgccgccaag     2460

gggcuccagu cccugcccac ccacgacccg agcccccugc agcgcuacuc cgaggacccc     2520

accgugcccc ucccgagcga gaccgacggc uacgucgcgc cccugacgug cuccccgcag     2580

cccgaguacg ugaaccagcc cgacgugcgg ccccagccgc ccagcccccg cgaggggccc     2640

cugcccgccg cccggcccgc cggcgccacc cucgagcgcc cgaagacccu gucccccggg     2700

aagaacggcg ucgugaagga cguguucgcg uucggcgggg ccgucgagaa ccccgaguac     2760

cugacgcccc agggcggggc cgccccgcag ccccacccgc cgcccgccuu cagccccgcg     2820

uucgacaacc ucuacuacug ggaccaggac ccgcccgagc ggggcgcccc gcccuccacc     2880

uucaagggca cccccaccgc cgagaacccc gaguaccugg ggcuggacgu gcccguguga     2940


<210>  1871
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Her2/neu__Homo_sapiens__BAG62073

<400>  1871
auggagcucg ccgcccucug ccgcuggggc cuccuccucg cccuccuccc ccccggcgcc       60

gccuccaccc aggacaacua ccucuccacc gacgucggcu ccugcacccu cgucugcccc      120

cuccacaacc aggaggucac cgccgaggac ggcacccagc gcugcgagaa gugcuccaag      180

cccugcgccc gcgucugcua cggccucggc auggagcacc uccgcgaggu ccgcgccguc      240

accuccgcca acauccagga guucgccggc ugcaagaaga ucuucggcuc ccucgccuuc      300

cuccccgagu ccuucgacgg cgaccccgcc uccaacaccg ccccccucca gcccgagcag      360

cuccaggucu ucgagacccu cgaggagauc accggcuacc ucuacaucuc cgccuggccc      420

gacucccucc ccgaccucuc cgucuuccag aaccuccagg ucauccgcgg ccgcauccuc      480

cacaacggcg ccuacucccu cacccuccag ggccucggca ucuccuggcu cggccuccgc      540

ucccuccgcg agcucggcuc cggccucgcc cucauccacc acaacaccca ccucugcuuc      600

guccacaccg uccccuggga ccagcucuuc cgcaaccccc accaggcccu ccuccacacc      660

gccaaccgcc ccgaggacga gugcgucggc gagggccucg ccugccacca gcucugcgcc      720

cgcggccacu gcuggggccc cggccccacc cagugcguca acugcuccca guuccuccgc      780

ggccaggagu gcgucgagga gugccgcguc cuccagggcc ucccccgcga guacgucaac      840

gcccgccacu gccuccccug ccaccccgag ugccagcccc agaacggcuc cgucaccugc      900

uucggccccg aggccgacca gugcgucgcc ugcgcccacu acaaggaccc ccccuucugc      960

gucgcccgcu gccccuccgg cgucaagccc gaccucuccu acaugcccau cuggaaguuc     1020

cccgacgagg agggcgccug ccagcccugc cccaucaacu gcacccacuc cugcgucgac     1080

cucgacgaca agggcugccc cgccgagcag cgcgccuccc cccucaccuc caucaucucc     1140

gccgucgucg gcauccuccu cgucgucguc cucggcgucg ucuucggcau ccucaucaag     1200

cgccgccagc agaagauccg caaguacacc augcgccgcc uccuccagga gaccgagcuc     1260

gucgagcccc ucacccccuc cggcgccaug cccaaccagg cccagaugcg cauccucaag     1320

gagaccgagc uccgcaaggu caagguccuc ggcuccggcg ccuucggcac cgucuacaag     1380

ggcaucugga uccccgacgg cgagaacguc aagauccccg ucgccaucaa gguccuccgc     1440

gagaacaccu cccccaaggc caacaaggag auccucgacg aggccuacgu cauggccggc     1500

gucggcuccc ccuacgucuc ccgccuccuc ggcaucugcc ucaccuccac cguccagcuc     1560

gucacccagc ucaugcccua cggcugccuc cucgaccacg uccgcgagaa ccgcggccgc     1620

cucggcuccc aggaccuccu caacuggugc augcagaucg ccaagggcau guccuaccuc     1680

gaggacgucc gccucgucca ccgcgaccuc gccgcccgca acguccucgu caaguccccc     1740

aaccacguca agaucaccga cuucggccuc gcccgccucc ucgacaucga cgagaccgag     1800

uaccacgccg acggcggcaa gguccccauc aaguggaugg cccucgaguc cauccuccgc     1860

cgccgcuuca cccaccaguc cgacgucugg uccuacggcg ucaccgucug ggagcucaug     1920

accuucggcg ccaagcccua cgacggcauc cccgcccgcg agauccccga ccuccucgag     1980

aagggcgagc gccuccccca gccccccauc ugcaccaucg acgucuacau gaucaugguc     2040

aagugcugga ugaucgacuc cgagugccgc ccccgcuucc gcgagcucgu cuccgaguuc     2100

ucccgcaugg cccgcgaccc ccagcgcuuc gucgucaucc agaacgagga ccucggcccc     2160

gccucccccc ucgacuccac cuucuaccgc ucccuccucg aggacgacga caugggcgac     2220

cucgucgacg ccgaggagua ccucgucccc cagcagggcu ucuucugccc cgaccccgcc     2280

cccggcgccg gcggcauggu ccaccaccgc caccgcuccu ccuccacccg cuccggcggc     2340

ggcgaccuca cccucggccu cgagcccucc gaggaggagg ccccccgcuc cccccucgcc     2400

cccuccgagg gcgccggcuc cgacgucuuc gacggcgacc ucggcauggg cgccgccaag     2460

ggccuccagu cccuccccac ccacgacccc uccccccucc agcgcuacuc cgaggacccc     2520

accguccccc uccccuccga gaccgacggc uacgucgccc cccucaccug cuccccccag     2580

cccgaguacg ucaaccagcc cgacguccgc ccccagcccc ccuccccccg cgagggcccc     2640

cuccccgccg cccgccccgc cggcgccacc cucgagcgcc ccaagacccu cucccccggc     2700

aagaacggcg ucgucaagga cgucuucgcc uucggcggcg ccgucgagaa ccccgaguac     2760

cucacccccc agggcggcgc cgccccccag ccccaccccc cccccgccuu cucccccgcc     2820

uucgacaacc ucuacuacug ggaccaggac ccccccgagc gcggcgcccc ccccuccacc     2880

uucaagggca cccccaccgc cgagaacccc gaguaccucg gccucgacgu ccccgucuga     2940


<210>  1872
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Her2/neu__Homo_sapiens__BAG62073

<400>  1872
auggagcugg ccgcucucug cagauggggc cuucuguugg cauuacugcc cccuggggcc       60

gcgagcaccc aggacaacua ccuauccaca gaugugggau cuuguacucu cgucugccca      120

cugcacaauc aagaaguuac ggcugaggac gguacccaga ggugugaaaa gugcucaaaa      180

ccgugugccc gggugugcua uggccuuggg auggagcauc ugcgcgaagu acgagcagug      240

acaagugcca acauccagga guucgcugga uguaagaaaa uuuuuggcag cuuggcauuc      300

cuccccgagu ccuuugaugg ugacccugcc ucuaauacug cuccacugca gcccgaacaa      360

cugcaggucu ucgagacccu cgaagagaua acaggguacu uauauaucuc ggccuggccu      420

gauucacugc cagaccuuag cguguuucag aacuugcagg uuauucgugg aagaauccug      480

cacaauggcg cguacagucu aacccuccaa ggccugggga uuuccuggcu uggacugagg      540

ucuuugcggg agcucgguag cggccuggca uuaauccauc acaacacuca ucugugcuuc      600

gugcacacag uccccuggga ucagcucuuu cgcaauccuc accaggcccu ucugcauacc      660

gcuaacagac cagaagacga gugugugggg gaaggauugg ccugccacca gcuaugugca      720

aggggccauu gcuggggucc ggggcccacg caaugcguaa auuguuccca guuccugcgg      780

ggacaggagu gcguugaaga gugucgcgug cuccaaggcc ugccucgaga guaugucaac      840

gcuagacacu gccuuccaug ucaccccgaa ugccagccuc agaauggcuc agugacuugu      900

uuugggccag aggccgauca gugcguggcg ugugcccauu acaaggaucc cccguucugc      960

gucgcaaggu guccuagugg aguuaaaccc gaccugagcu auaugccaau auggaaguuu     1020

ccugacgaag agggugcuug ccaacccugc ccaaucaacu guacccacuc uugcguggau     1080

uuggacgaca agggcugucc cgccgaacag cgggcuuccc cucucacauc aauuaucagc     1140

gccguagugg ggauucuguu agucgugguu cugggagugg ucuucggcau ccuaauaaaa     1200

cgucgccagc agaagauuag aaaauacacu augaggcggc uccugcaaga gaccgagcuu     1260

guggaaccau ugacaccgag uggugcaaug cccaaucagg cccagaugcg aauccugaag     1320

gagaccgaac uccgcaaagu aaagguucug gggucuggcg cuuuuggaac gguguacaag     1380

ggcauuugga ucccugaugg ggagaacguc aaaaucccag uggcgauuaa gguccuuaga     1440

gaaaauacuu cccccaaagc aaacaaggag auacuggacg aggccuaugu gauggcugga     1500

guugguagcc cuuacguguc gagguugcuc ggcaucugcc ugacaucuac cguacaguua     1560

gucacucaac ugaugccaua ugggugucua cucgaucaug ugcgggaaaa ccgcggaaga     1620

cugggcuccc aggaccuuuu gaauuggugc augcagauug ccaaagguau gucauaccug     1680

gaggauguua ggcucgugca ccgugaccug gcagcccgga acgucuuagu gaagaguccc     1740

aaucauguaa aaaucacaga uuucgggcug gcucgacuuu uggacauaga ugaaaccgag     1800

uaucacgccg acggcggaaa ggugccgauu aaguggaugg cacucgagag cauccugaga     1860

aggcgcuuca cgcaccaguc cgauguuugg ucuuacggcg ucaccgugug ggaacuaaug     1920

acauuugggg cgaaaccuua ugacggaauc ccagcucggg agauucccga ccugcucgaa     1980

aagggugaga gacugccuca acccccaauc uguacuauug auguguacau gauaaugguc     2040

aaaugcugga ugaucgacag cgaauguagg ccucgcuucc gagagcuugu uucagaguuu     2100

agucggaugg cccgugaucc ccagagauuc guggugauuc agaacgaaga cuugggccca     2160

gcauccccgc uggauagcac cuuuuacagg ucuuuacucg aggacgauga caugggggau     2220

cugguagacg ccgaagagua ucuugucccu caacagggau ucuuuugccc cgauccagcu     2280

cccggcgccg gugggauggu gcaucaccgc caucggucaa guagcacaag auccggcgga     2340

ggcgaccuga cuuuggggcu cgaaccuucu gaggaggaag caccaagguc gccccuggcu     2400

ccuagcgagg gagccggcuc cgauguuuuc gacggugacc uagggauggg agcggccaag     2460

ggccugcagu cacucccgac ccacgaucca aguccccugc agcgauacuc ugaagacccu     2520

acagugccac uucccagcga gaccgauggu uaugucgcuc cuuugacuug uuccccgcaa     2580

cccgaauacg ugaaucagcc agacguucgc ccucagcccc caucaccucg ggagggcccc     2640

cugccagcag ccagaccggc uggggccacg uuagagaggc cuaaaacacu cagccccgga     2700

aagaacggcg ugguaaagga ugucuuugca uucgggggag cgguggaaaa uccagaguau     2760

cugacucccc agggcggugc cgcuccucaa ccacacccuc ccccggccuu uucuccagca     2820

uucgacaacc uuuacuauug ggaucaggau cccccugaac guggggcucc cccauccacc     2880

uuuaaaggaa ccccuacagc cgagaauccc gaguaccugg gccuagacgu gccagucuga     2940


<210>  1873
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Her2/neu__Homo_sapiens__BAG62073

<400>  1873
auggagcugg ccgcccugug cagauggggc cugcugcugg cccugcugcc ccccggcgcc       60

gccagcaccc aggacaacua ccugagcacc gacgugggca gcugcacccu ggugugcccc      120

cugcacaacc aggaggugac cgccgaggac ggcacccaga gaugcgagaa gugcagcaag      180

cccugcgcca gagugugcua cggccugggc auggagcacc ugagagaggu gagagccgug      240

accagcgcca acauccagga guucgccggc ugcaagaaga ucuucggcag ccuggccuuc      300

cugcccgaga gcuucgacgg cgaccccgcc agcaacaccg ccccccugca gcccgagcag      360

cugcaggugu ucgagacccu ggaggagauc accggcuacc uguacaucag cgccuggccc      420

gacagccugc ccgaccugag cguguuccag aaccugcagg ugaucagagg cagaauccug      480

cacaacggcg ccuacagccu gacccugcag ggccugggca ucagcuggcu gggccugaga      540

agccugagag agcugggcag cggccuggcc cugauccacc acaacaccca ccugugcuuc      600

gugcacaccg ugcccuggga ccagcuguuc agaaaccccc accaggcccu gcugcacacc      660

gccaacagac ccgaggacga gugcgugggc gagggccugg ccugccacca gcugugcgcc      720

agaggccacu gcuggggccc cggccccacc cagugcguga acugcagcca guuccugaga      780

ggccaggagu gcguggagga gugcagagug cugcagggcc ugcccagaga guacgugaac      840

gccagacacu gccugcccug ccaccccgag ugccagcccc agaacggcag cgugaccugc      900

uucggccccg aggccgacca gugcguggcc ugcgcccacu acaaggaccc ccccuucugc      960

guggccagau gccccagcgg cgugaagccc gaccugagcu acaugcccau cuggaaguuc     1020

cccgacgagg agggcgccug ccagcccugc cccaucaacu gcacccacag cugcguggac     1080

cuggacgaca agggcugccc cgccgagcag agagccagcc cccugaccag caucaucagc     1140

gccguggugg gcauccugcu ggugguggug cugggcgugg uguucggcau ccugaucaag     1200

agaagacagc agaagaucag aaaguacacc augagaagac ugcugcagga gaccgagcug     1260

guggagcccc ugacccccag cggcgccaug cccaaccagg cccagaugag aauccugaag     1320

gagaccgagc ugagaaaggu gaaggugcug ggcagcggcg ccuucggcac cguguacaag     1380

ggcaucugga uccccgacgg cgagaacgug aagauccccg uggccaucaa ggugcugaga     1440

gagaacacca gccccaaggc caacaaggag auccuggacg aggccuacgu gauggccggc     1500

gugggcagcc ccuacgugag cagacugcug ggcaucugcc ugaccagcac cgugcagcug     1560

gugacccagc ugaugcccua cggcugccug cuggaccacg ugagagagaa cagaggcaga     1620

cugggcagcc aggaccugcu gaacuggugc augcagaucg ccaagggcau gagcuaccug     1680

gaggacguga gacuggugca cagagaccug gccgccagaa acgugcuggu gaagagcccc     1740

aaccacguga agaucaccga cuucggccug gccagacugc uggacaucga cgagaccgag     1800

uaccacgccg acggcggcaa ggugcccauc aaguggaugg cccuggagag cauccugaga     1860

agaagauuca cccaccagag cgacgugugg agcuacggcg ugaccgugug ggagcugaug     1920

accuucggcg ccaagcccua cgacggcauc cccgccagag agauccccga ccugcuggag     1980

aagggcgaga gacugcccca gccccccauc ugcaccaucg acguguacau gaucauggug     2040

aagugcugga ugaucgacag cgagugcaga cccagauuca gagagcuggu gagcgaguuc     2100

agcagaaugg ccagagaccc ccagagauuc guggugaucc agaacgagga ccugggcccc     2160

gccagccccc uggacagcac cuucuacaga agccugcugg aggacgacga caugggcgac     2220

cugguggacg ccgaggagua ccuggugccc cagcagggcu ucuucugccc cgaccccgcc     2280

cccggcgccg gcggcauggu gcaccacaga cacagaagca gcagcaccag aagcggcggc     2340

ggcgaccuga cccugggccu ggagcccagc gaggaggagg cccccagaag cccccuggcc     2400

cccagcgagg gcgccggcag cgacguguuc gacggcgacc ugggcauggg cgccgccaag     2460

ggccugcaga gccugcccac ccacgacccc agcccccugc agagauacag cgaggacccc     2520

accgugcccc ugcccagcga gaccgacggc uacguggccc cccugaccug cagcccccag     2580

cccgaguacg ugaaccagcc cgacgugaga ccccagcccc ccagccccag agagggcccc     2640

cugcccgccg ccagacccgc cggcgccacc cuggagagac ccaagacccu gagccccggc     2700

aagaacggcg uggugaagga cguguucgcc uucggcggcg ccguggagaa ccccgaguac     2760

cugacccccc agggcggcgc cgccccccag ccccaccccc cccccgccuu cagccccgcc     2820

uucgacaacc uguacuacug ggaccaggac ccccccgaga gaggcgcccc ccccagcacc     2880

uucaagggca cccccaccgc cgagaacccc gaguaccugg gccuggacgu gcccguguga     2940


<210>  1874
<211>  2940
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Her2/neu__Homo_sapiens__BAG62073

<400>  1874
auggagcugg ccgcucucug cagauggggc cugcuucugg cccuccugcc cccuggggcg       60

gcuagcaccc aggacaacua ccuuuccaca gaugugggau cuuguacgcu ggucugcccg      120

cuccacaauc aagaaguuac cgccgaggac ggcacacagc ggugugaaaa gugcagcaaa      180

cccugugccc gcgugugcua ugggcuggga auggagcacc ugagagaagu gcgggcuguc      240

accuccgcca acauccagga guucgcuggc uguaagaaaa uuuuuggguc ucucgccuuc      300

cugccugaga gcuuugaugg agaccccgcg uccaauacag ccccucuuca gcccgaacaa      360

cuccaggugu ucgagacccu ggaagagauc acaggcuacc uguauauuuc ugcuuggccu      420

gauagccuuc cggaccuguc cguuuuucag aaccuccagg ugauccgcgg ccggauucug      480

cacaaugggg ccuacagccu gacccuccaa ggacugggca ucucuuggcu ugggcugcgg      540

ucccuccgcg agcugggaag cggccuugcu cugauccauc acaacacgca ucucugcuuc      600

guccacaccg ugcccuggga ucagcuguuu agaaauccuc accaggcccu gcuccauaca      660

gcgaaccggc ccgaagacga guguguuggg gaaggacugg ccugccacca gcuuugugcu      720

cgcggccauu gcuggggccc ugggcccacc caaugcguga auuguucuca guuccugaga      780

ggacaggagu gcgucgaaga gugucgggug cuccaaggcc ugccgcgcga guaugugaac      840

gccagacacu gccuuccuug ucaccccgaa ugccagccuc agaauggguc cgucacaugu      900

uuuggacccg aggcugauca gugcguugcc ugugcccauu acaaggaucc cccuuucugc      960

guggcucggu guccgagcgg cgugaaaccc gaccugucuu auaugccuau uuggaaguuu     1020

cccgacgaag agggggcgug ccaaccuugc cccaucaacu guacccacuc cugcgucgau     1080

cucgacgaca agggaugucc ggccgaacag cgcgcuagcc cucugacguc cauuaucucu     1140

gccgugguug gcauucugcu cguggucgug cugggcguug uguucgggau ccuuauuaaa     1200

agacggcagc agaagaucag aaaauacaca augcgccggc ugcuccaaga gaccgagcug     1260

gucgaacccc ugacaccuag cggagccaug cccaaucagg cucagaugag aauccuuaag     1320

gagaccgaac uccgcaaagu gaagguccug ggcuccgggg ccuuuggaac cguguacaag     1380

ggcauuugga ucccugaugg ggagaacguu aaaauucccg uggcgaucaa gguccugcgg     1440

gaaaauacaa gcccgaaagc uaacaaggag auucucgacg aggccuaugu gauggccggc     1500

guuggaucuc cuuacguguc cagacugcuu ggcaucugcc ugacgagcac cguccagcuc     1560

gugacacaac ugaugcccua ugggugucug cuugaucaug ugcgcgaaaa ccggggaaga     1620

cucggcucuc aggaccugcu gaauuggugc augcagaucg cuaaagggau gagcuaccuc     1680

gaggauguuc gccuggucca ccgggaccuu gccgcuagaa acgugcuggu gaaguccccc     1740

aaucauguca aaauuaccga uuucggacuc gcccgccugc uggacaucga ugaaacagag     1800

uaucacgcgg acggcgggaa ggugccuauu aaguggaugg cccuugaguc uauccuccgg     1860

agacgguuca cccaccagag cgauguuugg uccuacggcg ugacggucug ggaacugaug     1920

acauuuggag cuaaaccgua ugacggcauu cccgcccgcg agaucccuga ccugcucgaa     1980

aagggggaga gacugcccca accucccauc uguaccauug auguguacau gaucaugguu     2040

aaaugcugga ugauugacag cgaaugucgg ccuagauucc gcgagcuugu gucugaguuu     2100

ucccggaugg cuagagaucc ccagcgcuuc gucgugaucc agaacgaaga ccugggaccg     2160

gccagcccuc ucgauucuac cuuuuacaga ucccugcugg aggacgauga caugggcgau     2220

cuuguugacg cggaagagua ucucgugccc caacaggggu ucuuuugccc ugaucccgcc     2280

ccgggagcug gcgggauggu ccaucaccgg caucgcagcu ccucuacaag aagcggcgga     2340

ggcgaccuga cccuggggcu cgaaccuucc gaggaggaag cccccagauc uccucuggcu     2400

cccagcgagg gagccggcuc cgauguguuc gacggggacc uuggaauggg cgccgcuaag     2460

gggcugcaga gccuccccac acacgauccu ucuccgcugc agcgcuacuc cgaagacccc     2520

acggugccuc ugcccagcga gaccgauggc uaugucgcgc cucuuacaug uucuccccaa     2580

ccugaauacg uuaaucagcc ggacgugaga ccccagccuc ccuccccucg ggagggaccc     2640

cugccggccg cucgcccugc cggcgccacc cucgagagac ccaaaacacu gagccccggg     2700

aagaacggag uggucaagga uguguuugcu uucggcgggg ccguugaaaa uccugaguau     2760

cucacgcccc agggaggcgc ggcuccucaa ccgcaucccc cucccgccuu uucuccugcc     2820

uucgacaacc uguacuauug ggaucaggau cccccggaac ggggcgcucc ucccagcacc     2880

uuuaaaggga ccccuacagc cgagaauccc gaguaccuug gacuggacgu gccugucuga     2940


<210>  1875
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__L8E8G2

<400>  1875

Met Met Arg Met Lys Thr Phe Val Met Ile His Phe His Leu Met Asn 
1               5                   10                  15      


Gly Gly Lys Ala Lys Leu Tyr Ser Arg Pro His Ala Lys Leu Leu Pro 
            20                  25                  30          


Glu Gln Arg Val Thr Asp Lys Thr Gly Ala Pro Val Glu Trp Pro Gly 
        35                  40                  45              


Gln Thr Gln Cys Ser Thr Glu Thr Gln Thr Leu Ala Ala Met Pro Ala 
    50                  55                  60                  


Gln Ala Val Met Arg Val Thr Cys Thr Val Val Asp Met His Lys Ser 
65                  70                  75                  80  


Glu Cys Ala Pro Ala Gln Thr 
                85          


<210>  1876
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__CCQ43016

<400>  1876
augaugagga ugaaaaccuu ugugaugauc cacuuccacu uaaugaaugg uggcaaagca       60

aagcuauauu caagaccaca ugcaaagcua cucccugagc aaagagucac agauaaaacg      120

ggggcaccag uagaauggcc aggacaaacg cagugcagca cagagacuca gacccuggca      180

gccaugccug cgcaggcagu gaugagagug acauguacug uuguggacau gcacaaaagu      240

gagugugcac cggcacagac auga                                             264


<210>  1877
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Her2/neu__Homo_sapiens__CCQ43016

<400>  1877
augaugcgca ugaagaccuu cgugaugauc cacuuccacc ugaugaacgg cgggaaggcc       60

aagcucuaca gccggcccca cgccaagcug cugccggagc agcgcgucac cgacaagacg      120

ggcgcgcccg uggaguggcc cgggcagacc cagugcucca ccgagaccca gacgcucgcc      180

gccaugcccg cccaggccgu gaugcgggug accugcaccg ucguggacau gcacaagagc      240

gagugcgcgc cggcccagac cuga                                             264


<210>  1878
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Her2/neu__Homo_sapiens__CCQ43016

<400>  1878
augaugcgca ugaagaccuu cgucaugauc cacuuccacc ucaugaacgg cggcaaggcc       60

aagcucuacu cccgccccca cgccaagcuc cuccccgagc agcgcgucac cgacaagacc      120

ggcgcccccg ucgaguggcc cggccagacc cagugcucca ccgagaccca gacccucgcc      180

gccaugcccg cccaggccgu caugcgcguc accugcaccg ucgucgacau gcacaagucc      240

gagugcgccc ccgcccagac cuga                                             264


<210>  1879
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Her2/neu__Homo_sapiens__CCQ43016

<400>  1879
augaugagaa ugaagaccuu cgugaugauc cacuuucauc ugaugaacgg cgggaaagcc       60

aagcucuaca gcaggcccca cgcuaaacuu cugccugagc agcgggucac agacaagacu      120

ggagcaccag uugaauggcc gggucaaacg cagugcucca ccgagacaca gacuuuggcc      180

gcgaugcccg cucaggccgu gaugcgcgua accuguacag uggucgauau gcauaaaucu      240

gaaugcgccc cugcacaaac cuga                                             264


<210>  1880
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Her2/neu__Homo_sapiens__CCQ43016

<400>  1880
augaugagaa ugaagaccuu cgugaugauc cacuuccacc ugaugaacgg cggcaaggcc       60

aagcuguaca gcagacccca cgccaagcug cugcccgagc agagagugac cgacaagacc      120

ggcgcccccg uggaguggcc cggccagacc cagugcagca ccgagaccca gacccuggcc      180

gccaugcccg cccaggccgu gaugagagug accugcaccg ugguggacau gcacaagagc      240

gagugcgccc ccgcccagac cuga                                             264


<210>  1881
<211>  264
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Her2/neu__Homo_sapiens__CCQ43016

<400>  1881
augaugagaa ugaagaccuu cgugaugauc cacuuucauc ugaugaacgg cgggaaagcc       60

aagcucuaca gccggcccca cgcuaaacug cuuccugagc agcgcgucac agacaagacg      120

ggagccccgg uugaauggcc cggccaaacc cagugcucca cagagaccca gacacuggcg      180

gcuaugccug cccaggccgu gaugagagug accuguacag ucguggauau gcauaaaucu      240

gaaugcgcuc ccgcccaaac cuga                                             264


<210>  1882
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__P04626

<400>  1882

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu 
        995                 1000                1005            


Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu 
    1010                1015                1020                


Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly 
1025                1030                1035                1040


Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly 
                1045                1050                1055    


Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg 
            1060                1065                1070        


Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly 
        1075                1080                1085            


Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His 
    1090                1095                1100                


Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu 
1105                1110                1115                1120


Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln 
                1125                1130                1135    


Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro 
            1140                1145                1150        


Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu 
        1155                1160                1165            


Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val 
    1170                1175                1180                


Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln 
1185                1190                1195                1200


Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala 
                1205                1210                1215    


Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala 
            1220                1225                1230        


Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr 
        1235                1240                1245            


Leu Gly Leu Asp Val Pro Val 
    1250                1255


<210>  1883
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__AAI67147

<400>  1883
auggagcugg cggccuugug ccgcuggggg cuccuccucg cccucuugcc ccccggagcc       60

gcgagcaccc aagugugcac cggcacagac augaagcugc ggcucccugc cagucccgag      120

acccaccugg acaugcuccg ccaccucuac cagggcugcc agguggugca gggaaaccug      180

gaacucaccu accugcccac caaugccagc cuguccuucc ugcaggauau ccaggaggug      240

cagggcuacg ugcucaucgc ucacaaccaa gugaggcagg ucccacugca gaggcugcgg      300

auugugcgag gcacccagcu cuuugaggac aacuaugccc uggccgugcu agacaaugga      360

gacccgcuga acaauaccac cccugucaca ggggccuccc caggaggccu gcgggagcug      420

cagcuucgaa gccucacaga gaucuugaaa ggaggggucu ugauccagcg gaacccccag      480

cucugcuacc aggacacgau uuuguggaag gacaucuucc acaagaacaa ccagcuggcu      540

cucacacuga uagacaccaa ccgcucucgg gccugccacc ccuguucucc gauguguaag      600

ggcucccgcu gcuggggaga gaguucugag gauugucaga gccugacgcg cacugucugu      660

gccgguggcu gugcccgcug caaggggcca cugcccacug acugcugcca ugagcagugu      720

gcugccggcu gcacgggccc caagcacucu gacugccugg ccugccucca cuucaaccac      780

aguggcaucu gugagcugca cugcccagcc cuggucaccu acaacacaga cacguuugag      840

uccaugccca aucccgaggg ccgguauaca uucggcgcca gcugugugac ugccuguccc      900

uacaacuacc uuucuacgga cgugggaucc ugcacccucg ucugcccccu gcacaaccaa      960

gaggugacag cagaggaugg aacacagcgg ugugagaagu gcagcaagcc cugugcccga     1020

gugugcuaug gucugggcau ggagcacuug cgagagguga gggcaguuac cagugccaau     1080

auccaggagu uugcuggcug caagaagauc uuugggagcc uggcauuucu gccggagagc     1140

uuugaugggg acccagccuc caacacugcc ccgcuccagc cagagcagcu ccaaguguuu     1200

gagacucugg aagagaucac agguuaccua uacaucucag cauggccgga cagccugccu     1260

gaccucagcg ucuuccagaa ccugcaagua auccggggac gaauucugca caauggcgcc     1320

uacucgcuga cccugcaagg gcugggcauc agcuggcugg ggcugcgcuc acugagggaa     1380

cugggcagug gacuggcccu cauccaccau aacacccacc ucugcuucgu gcacacggug     1440

cccugggacc agcucuuucg gaacccgcac caagcucugc uccacacugc caaccggcca     1500

gaggacgagu gugugggcga gggccuggcc ugccaccagc ugugcgcccg agggcacugc     1560

ugggguccag ggcccaccca gugugucaac ugcagccagu uccuucgggg ccaggagugc     1620

guggaggaau gccgaguacu gcaggggcuc cccagggagu augugaaugc caggcacugu     1680

uugccgugcc acccugagug ucagccccag aauggcucag ugaccuguuu uggaccggag     1740

gcugaccagu guguggccug ugcccacuau aaggacccuc ccuucugcgu ggcccgcugc     1800

cccagcggug ugaaaccuga ccucuccuac augcccaucu ggaaguuucc agaugaggag     1860

ggcgcaugcc agccuugccc caucaacugc acccacuccu guguggaccu ggaugacaag     1920

ggcugccccg ccgagcagag agccagcccu cugacgucca ucaucucugc ggugguuggc     1980

auucugcugg ucguggucuu gggggugguc uuugggaucc ucaucaagcg acggcagcag     2040

aagauccgga aguacacgau gcggagacug cugcaggaaa cggagcuggu ggagccgcug     2100

acaccuagcg gagcgaugcc caaccaggcg cagaugcgga uccugaaaga gacggagcug     2160

aggaagguga aggugcuugg aucuggcgcu uuuggcacag ucuacaaggg caucuggauc     2220

ccugaugggg agaaugugaa aauuccagug gccaucaaag uguugaggga aaacacaucc     2280

cccaaagcca acaaagaaau cuuagacgaa gcauacguga uggcuggugu gggcucccca     2340

uaugucuccc gccuucuggg caucugccug acauccacgg ugcagcuggu gacacagcuu     2400

augcccuaug gcugccucuu agaccauguc cgggaaaacc gcggacgccu gggcucccag     2460

gaccugcuga acugguguau gcagauugcc aaggggauga gcuaccugga ggaugugcgg     2520

cucguacaca gggacuuggc cgcucggaac gugcugguca agagucccaa ccaugucaaa     2580

auuacagacu ucgggcuggc ucggcugcug gacauugacg agacagagua ccaugcagau     2640

gggggcaagg ugcccaucaa guggauggcg cuggagucca uucuccgccg gcgguucacc     2700

caccagagug auguguggag uuauggugug acuguguggg agcugaugac uuuuggggcc     2760

aaaccuuacg augggauccc agcccgggag aucccugacc ugcuggaaaa gggggagcgg     2820

cugccccagc cccccaucug caccauugau gucuacauga ucauggucaa auguuggaug     2880

auugacucug aaugucggcc aagauuccgg gaguuggugu cugaauucuc ccgcauggcc     2940

agggaccccc agcgcuuugu ggucauccag aaugaggacu ugggcccagc cagucccuug     3000

gacagcaccu ucuaccgcuc acugcuggag gacgaugaca ugggggaccu gguggaugcu     3060

gaggaguauc ugguacccca gcagggcuuc uucuguccag acccugcccc gggcgcuggg     3120

ggcauggucc accacaggca ccgcagcuca ucuaccagga guggcggugg ggaccugaca     3180

cuagggcugg agcccucuga agaggaggcc cccaggucuc cacuggcacc cuccgaaggg     3240

gcuggcuccg auguauuuga uggugaccug ggaauggggg cagccaaggg gcugcaaagc     3300

cuccccacac augaccccag cccucuacag cgguacagug aggaccccac aguaccccug     3360

cccucugaga cugauggcua cguugccccc cugaccugca gcccccagcc ugaauaugug     3420

aaccagccag auguucggcc ccagcccccu ucgccccgag agggcccucu gccugcugcc     3480

cgaccugcug gugccacucu ggaaaggccc aagacucucu ccccagggaa gaaugggguc     3540

gucaaagacg uuuuugccuu ugggggugcc guggagaacc ccgaguacuu gacaccccag     3600

ggaggagcug ccccucagcc ccacccuccu ccugccuuca gcccagccuu cgacaaccuc     3660

uauuacuggg accaggaccc accagagcgg ggggcuccac ccagcaccuu caaagggaca     3720

ccuacggcag agaacccaga guaccugggu cuggacgugc caguguga                  3768


<210>  1884
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Her2/neu__Homo_sapiens__AAI67147

<400>  1884
auggagcugg ccgcccucug ccgcuggggc cugcugcucg cgcugcugcc cccgggggcc       60

gccagcaccc aggugugcac cggcacggac augaagcucc ggcugcccgc cucccccgag      120

acccaccugg acaugcuccg ccaccuguac caggggugcc aggucgugca gggcaaccug      180

gagcucaccu accugcccac caacgccagc cuguccuucc uccaggacau ccaggaggug      240

cagggguacg uccugaucgc gcacaaccag gugcgccagg ugccgcugca gcggcuccgg      300

aucguccgcg gcacgcagcu guucgaggac aacuacgccc uggccgugcu cgacaacggc      360

gacccccuga acaacaccac ccccgugacc ggggccagcc ccggcgggcu gcgggagcuc      420

cagcugcgcu cccugacgga gauccucaag ggcggggucc ugauccagcg gaacccgcag      480

cugugcuacc aggacaccau ccucuggaag gacaucuucc acaagaacaa ccagcuggcg      540

cugacccuca ucgacaccaa ccgcagccgg gccugccacc ccugcucccc caugugcaag      600

ggcagccgcu gcuggggcga guccagcgag gacugccagu cccugacgcg gaccgugugc      660

gccgggggcu gcgcccgcug caaggggccc cugccgaccg acugcugcca cgagcagugc      720

gccgcgggcu gcaccggccc caagcacagc gacugccucg ccugccugca cuucaaccac      780

uccgggaucu gcgagcugca cugccccgcc cucgugacgu acaacaccga caccuucgag      840

agcaugccca acccggaggg ccgguacacc uucggggccu ccugcgucac ggccugcccc      900

uacaacuacc ugagcaccga cgugggcucc ugcacccugg ugugcccccu ccacaaccag      960

gaggucaccg cggaggacgg gacgcagcgc ugcgagaagu gcagcaagcc cugcgcccgg     1020

gugugcuacg gccugggcau ggagcaccuc cgcgaggugc gggccgucac cuccgccaac     1080

auccaggagu ucgccgggug caagaagauc uucggcagcc uggcguuccu gccggagagc     1140

uucgacgggg accccgccuc caacaccgcg ccccugcagc ccgagcagcu ccagguguuc     1200

gagacccugg aggagaucac gggcuaccug uacaucagcg ccuggccgga cucccugccc     1260

gaccucagcg uguuccagaa ccugcagguc auccgcgggc ggauccugca caacggcgcc     1320

uacucccuca cccugcaggg ccuggggauc agcuggcucg gccugcgcuc ccugcgcgag     1380

cucgggagcg gccuggcccu gauccaccac aacacccacc ucugcuucgu gcacaccgug     1440

cccugggacc agcuguuccg gaacccccac caggcccugc uccacacggc caaccgcccc     1500

gaggacgagu gcgucgggga gggccuggcc ugccaccagc ugugcgcgcg gggccacugc     1560

ugggggcccg gccccaccca gugcgugaac ugcucccagu uccuccgcgg gcaggagugc     1620

gucgaggagu gccgggugcu gcagggccug ccgcgcgagu acgugaacgc ccggcacugc     1680

cuccccugcc accccgagug ccagccccag aacggcagcg ugaccugcuu cgggccggag     1740

gccgaccagu gcguggccug cgcccacuac aaggacccgc ccuucugcgu ggcgcgcugc     1800

cccuccggcg ucaagcccga ccugagcuac augcccaucu ggaaguuccc cgacgaggag     1860

ggggccugcc agcccugccc gaucaacugc acccacuccu gcguggaccu ggacgacaag     1920

ggcugccccg ccgagcagcg ggccagcccc cucacgucca ucaucagcgc cguggucggg     1980

auccugcugg uggugguccu cggcguggug uucggcaucc ugaucaagcg ccggcagcag     2040

aagauccgca aguacaccau gcggcgccug cuccaggaga ccgagcuggu cgagccccug     2100

accccguccg gggcgaugcc caaccaggcc cagaugcgga uccucaagga gaccgagcug     2160

cgcaagguga aggugcuggg cagcggggcc uucggcacgg ucuacaaggg gaucuggauc     2220

cccgacggcg agaacgugaa gauccccgug gccaucaagg uccuccggga gaacaccucc     2280

ccgaaggcca acaaggagau ccuggacgag gcguacguga uggccggcgu ggggagcccc     2340

uacgucagcc gccugcucgg caucugccug accuccaccg ugcagcuggu gacgcagcuc     2400

augcccuacg ggugccugcu ggaccacguc cgggagaacc gcggccgccu cgggagccag     2460

gaccugcuga acuggugcau gcagaucgcc aagggcaugu ccuaccucga ggacgugcgg     2520

cuggugcacc gcgaccuggc cgcgcggaac guccucguca agagccccaa ccacgugaag     2580

aucaccgacu ucggccuggc ccgccugcuc gacaucgacg agaccgagua ccacgccgac     2640

gggggcaagg ucccgaucaa guggauggcc cuggagucca uccugcggcg ccgguucacc     2700

caccagagcg acgugugguc cuacggggug acggucuggg agcucaugac cuucggcgcc     2760

aagcccuacg acgggauccc cgcgcgcgag aucccggacc ugcuggagaa gggcgagcgg     2820

cucccccagc cgcccaucug caccaucgac guguacauga ucauggugaa gugcuggaug     2880

aucgacagcg agugccgccc ccgguuccgc gagcuggucu ccgaguucag ccggauggcc     2940

cgcgaccccc agcgguucgu ggugauccag aacgaggacc ugggccccgc cagcccccuc     3000

gacuccaccu ucuaccgcuc ccugcuggag gacgacgaca ugggggaccu cgucgacgcc     3060

gaggaguacc uggugccgca gcagggcuuc uucugccccg accccgcccc cggggcgggc     3120

ggcauggugc accaccggca ccgcagcucc agcacgcggu ccgggggcgg ggaccugacc     3180

cucggccugg agccgagcga ggaggaggcg ccccgcagcc cccuggcccc cuccgagggg     3240

gccggcagcg acgucuucga cggcgaccuc gggaugggcg ccgccaaggg gcugcagucc     3300

cugccgaccc acgaccccag cccccuccag cgguacuccg aggaccccac cgugccgcug     3360

cccagcgaga cggacggcua cguggcgccc cugaccugcu ccccgcagcc cgaguacguc     3420

aaccagcccg acgugcgccc ccagcccccg agcccccgcg aggggccccu cccggccgcc     3480

cggcccgccg gcgccacccu ggagcgcccc aagacccugu cccccggcaa gaacggggug     3540

gucaaggacg uguucgccuu cggcggggcc gucgagaacc cggaguaccu cacgccccag     3600

ggcggggccg cgccccagcc ccacccgccg cccgccuuca gccccgccuu cgacaaccug     3660

uacuacuggg accaggaccc gcccgagcgg ggcgccccgc ccuccaccuu caagggcacc     3720

cccaccgccg agaaccccga guaccugggg cucgacgugc ccguguga                  3768


<210>  1885
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Her2/neu__Homo_sapiens__AAI67147

<400>  1885
auggagcucg ccgcccucug ccgcuggggc cuccuccucg cccuccuccc ccccggcgcc       60

gccuccaccc aggucugcac cggcaccgac augaagcucc gccuccccgc cucccccgag      120

acccaccucg acaugcuccg ccaccucuac cagggcugcc aggucgucca gggcaaccuc      180

gagcucaccu accuccccac caacgccucc cucuccuucc uccaggacau ccaggagguc      240

cagggcuacg uccucaucgc ccacaaccag guccgccagg ucccccucca gcgccuccgc      300

aucguccgcg gcacccagcu cuucgaggac aacuacgccc ucgccguccu cgacaacggc      360

gacccccuca acaacaccac ccccgucacc ggcgccuccc ccggcggccu ccgcgagcuc      420

cagcuccgcu cccucaccga gauccucaag ggcggcgucc ucauccagcg caacccccag      480

cucugcuacc aggacaccau ccucuggaag gacaucuucc acaagaacaa ccagcucgcc      540

cucacccuca ucgacaccaa ccgcucccgc gccugccacc ccugcucccc caugugcaag      600

ggcucccgcu gcuggggcga guccuccgag gacugccagu cccucacccg caccgucugc      660

gccggcggcu gcgcccgcug caagggcccc cuccccaccg acugcugcca cgagcagugc      720

gccgccggcu gcaccggccc caagcacucc gacugccucg ccugccucca cuucaaccac      780

uccggcaucu gcgagcucca cugccccgcc cucgucaccu acaacaccga caccuucgag      840

uccaugccca accccgaggg ccgcuacacc uucggcgccu ccugcgucac cgccugcccc      900

uacaacuacc ucuccaccga cgucggcucc ugcacccucg ucugcccccu ccacaaccag      960

gaggucaccg ccgaggacgg cacccagcgc ugcgagaagu gcuccaagcc cugcgcccgc     1020

gucugcuacg gccucggcau ggagcaccuc cgcgaggucc gcgccgucac cuccgccaac     1080

auccaggagu ucgccggcug caagaagauc uucggcuccc ucgccuuccu ccccgagucc     1140

uucgacggcg accccgccuc caacaccgcc ccccuccagc ccgagcagcu ccaggucuuc     1200

gagacccucg aggagaucac cggcuaccuc uacaucuccg ccuggcccga cucccucccc     1260

gaccucuccg ucuuccagaa ccuccagguc auccgcggcc gcauccucca caacggcgcc     1320

uacucccuca cccuccaggg ccucggcauc uccuggcucg gccuccgcuc ccuccgcgag     1380

cucggcuccg gccucgcccu cauccaccac aacacccacc ucugcuucgu ccacaccguc     1440

cccugggacc agcucuuccg caacccccac caggcccucc uccacaccgc caaccgcccc     1500

gaggacgagu gcgucggcga gggccucgcc ugccaccagc ucugcgcccg cggccacugc     1560

uggggccccg gccccaccca gugcgucaac ugcucccagu uccuccgcgg ccaggagugc     1620

gucgaggagu gccgcguccu ccagggccuc ccccgcgagu acgucaacgc ccgccacugc     1680

cuccccugcc accccgagug ccagccccag aacggcuccg ucaccugcuu cggccccgag     1740

gccgaccagu gcgucgccug cgcccacuac aaggaccccc ccuucugcgu cgcccgcugc     1800

cccuccggcg ucaagcccga ccucuccuac augcccaucu ggaaguuccc cgacgaggag     1860

ggcgccugcc agcccugccc caucaacugc acccacuccu gcgucgaccu cgacgacaag     1920

ggcugccccg ccgagcagcg cgccuccccc cucaccucca ucaucuccgc cgucgucggc     1980

auccuccucg ucgucguccu cggcgucguc uucggcaucc ucaucaagcg ccgccagcag     2040

aagauccgca aguacaccau gcgccgccuc cuccaggaga ccgagcucgu cgagccccuc     2100

acccccuccg gcgccaugcc caaccaggcc cagaugcgca uccucaagga gaccgagcuc     2160

cgcaagguca agguccucgg cuccggcgcc uucggcaccg ucuacaaggg caucuggauc     2220

cccgacggcg agaacgucaa gauccccguc gccaucaagg uccuccgcga gaacaccucc     2280

cccaaggcca acaaggagau ccucgacgag gccuacguca uggccggcgu cggcuccccc     2340

uacgucuccc gccuccucgg caucugccuc accuccaccg uccagcucgu cacccagcuc     2400

augcccuacg gcugccuccu cgaccacguc cgcgagaacc gcggccgccu cggcucccag     2460

gaccuccuca acuggugcau gcagaucgcc aagggcaugu ccuaccucga ggacguccgc     2520

cucguccacc gcgaccucgc cgcccgcaac guccucguca agucccccaa ccacgucaag     2580

aucaccgacu ucggccucgc ccgccuccuc gacaucgacg agaccgagua ccacgccgac     2640

ggcggcaagg uccccaucaa guggauggcc cucgagucca uccuccgccg ccgcuucacc     2700

caccaguccg acgucugguc cuacggcguc accgucuggg agcucaugac cuucggcgcc     2760

aagcccuacg acggcauccc cgcccgcgag auccccgacc uccucgagaa gggcgagcgc     2820

cucccccagc cccccaucug caccaucgac gucuacauga ucauggucaa gugcuggaug     2880

aucgacuccg agugccgccc ccgcuuccgc gagcucgucu ccgaguucuc ccgcauggcc     2940

cgcgaccccc agcgcuucgu cgucauccag aacgaggacc ucggccccgc cuccccccuc     3000

gacuccaccu ucuaccgcuc ccuccucgag gacgacgaca ugggcgaccu cgucgacgcc     3060

gaggaguacc ucguccccca gcagggcuuc uucugccccg accccgcccc cggcgccggc     3120

ggcauggucc accaccgcca ccgcuccucc uccacccgcu ccggcggcgg cgaccucacc     3180

cucggccucg agcccuccga ggaggaggcc ccccgcuccc cccucgcccc cuccgagggc     3240

gccggcuccg acgucuucga cggcgaccuc ggcaugggcg ccgccaaggg ccuccagucc     3300

cuccccaccc acgaccccuc cccccuccag cgcuacuccg aggaccccac cgucccccuc     3360

cccuccgaga ccgacggcua cgucgccccc cucaccugcu ccccccagcc cgaguacguc     3420

aaccagcccg acguccgccc ccagcccccc uccccccgcg agggcccccu ccccgccgcc     3480

cgccccgccg gcgccacccu cgagcgcccc aagacccucu cccccggcaa gaacggcguc     3540

gucaaggacg ucuucgccuu cggcggcgcc gucgagaacc ccgaguaccu caccccccag     3600

ggcggcgccg ccccccagcc ccaccccccc cccgccuucu cccccgccuu cgacaaccuc     3660

uacuacuggg accaggaccc ccccgagcgc ggcgcccccc ccuccaccuu caagggcacc     3720

cccaccgccg agaaccccga guaccucggc cucgacgucc ccgucuga                  3768


<210>  1886
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Her2/neu__Homo_sapiens__AAI67147

<400>  1886
auggagcugg ccgcucucug cagauggggc cuucuguugg cauuacugcc cccuggggcc       60

gcgagcaccc agguguguac aggaacugac augaagcuaa ggcucccagc uuccccggaa      120

acgcaccugg auaugcuucg gcaucuguac caagguugcc aggucguuca gggcaacuug      180

gagcucaccu aucugcccac aaaugccucu cugucauucc uccaggacau ccaagaagug      240

cagggguacg uauuaauugc acacaaccag gugcgccagg ucccucugca acgacuucgu      300

auagugagag gaacucaguu guuugaggau aauuaugccc uggcuguucu agacaacggc      360

gauccacuca auaacaccac acccgugacc ggugcaaguc cugggggacu gagggaacuu      420

cagcugcgga gcuugacuga gauccucaaa ggcggcgucc ugauucagcg caauccacaa      480

uuauguuacc aggacacaau ccuguggaag gauauuuucc auaaaaacaa ucagcucgcc      540

cuuacccuga ucgacacgaa cagauccagg gcuugccacc ccuguucucc uaugugcaag      600

gggucgcggu guuggggaga gucaagcgaa gauugccaaa guuugacucg caccgugugu      660

gccgguggcu gcgcgcgaug uaaagggcca cuaccgacag acugcugcca ugagcagugu      720

gcagccggau gcacuggccc caagcacucc gauugucugg cuugccucca cuuuaaucau      780

ucugguauau gugaacugca cugcccugcc cuuguaaccu auaacacaga caccuucgag      840

agcaugccaa aucccgaggg gagauacacg uuuggagcau ccuguguuac ugcuugcccu      900

uauaacuacc ugucaacaga ugugggcagu uguaccuugg ucugcccacu ccauaaucag      960

gaagugacug ccgaggacgg cacacagagg ugugaaaagu gcagcaaacc cugcgcgcgg     1020

guguguuacg ggcugggaau ggagcacuua cgugaagucc gcgccguuac cucugcaaac     1080

auccaagagu ucgcugguug caagaaaauu uuuggcuccc uggccuuccu accggaguca     1140

uuugacgggg auccugcuag caacacggca ccccuccagc cagaacagcu ucagguguuc     1200

gagacccugg aagagaucac aggauauuug uacauuagug ccuggccuga cucucugccc     1260

gaucucuccg uauuucaaaa ucuucaggug aucagaggca ggauacugca caacggugcc     1320

uauagccuga cuuugcaggg gcucggcauu ucguggcugg gauuacgguc ucugcgagaa     1380

cuaggcuccg ggcucgcucu gauccaucac aauacccauc uuuguuucgu ccacacagug     1440

ccaugggacc aguuguuucg caacccccau caagcgcugc uccacacugc aaauagaccu     1500

gaggaugagu gcguuggaga aggucuggcc ugucaccagu uaugcgcuag gggccauugu     1560

ugggggccag gaccgaccca gugcgugaac uguucacagu uccugcgggg ccaagagugc     1620

gucgaagagu gucgcgugcu ucaggguuug cccagagaau acguaaaugc caggcacugc     1680

cucccuugcc auccagagug ucagccccaa aacgggagug uuacaugcuu cggcccugag     1740

gcagaccagu guguggccug cgcucacuau aaggauccac ccuuuugugu cgcccguugc     1800

ccgagcggag ugaaaccuga ccuguccuac augccaauuu ggaaguuccc cgaugaagag     1860

ggcgcauguc agccuugccc caucaauugu acccacucuu gcgucgaccu agaugacaag     1920

ggguguccag cggaacagcg ggcuagcccu cugacuucaa ucauuagugc cgugguugga     1980

auacuccugg ugguaguccu uggugugguu uuuggcaucu ugauuaaacg aagacaacag     2040

aagaucagga aauauacgau gcgccggcug uuacaggaga cagagcucgu ggaaccccug     2100

accccauccg gggcaaugcc gaaccaggcc caaaugagaa uacuuaagga gacugaacug     2160

aggaaaguca agguguuggg aagcggcgcu uucgguaccg uauacaaagg gauuuggauc     2220

ccugacggcg agaaugugaa gauccccguu gccauuaagg uccuccgcga aaacacaucu     2280

ccaaaagcaa auaaggagau ccuggaugag gcuuacguga uggccggagu gggcucaccc     2340

uaugucaguc gacuacuggg gauuugccuc accagcacug uucagcuggu gacacagcuu     2400

augccuuacg gaugcuugcu ggaccaugug cgggaaaacc guggcagauu agguucccag     2460

gaucuccuga auugguguau gcaaauagcg aaagggaugu cuuaucuuga ggacguaagg     2520

cugguccacc gcgaucuagc cgcucggaac gugcucguua agucgccaaa ccaugugaaa     2580

aucacggacu uuggacuggc aagauugcug gauauugacg aaaccgagua ccacgccgau     2640

ggcgguaagg uccccaucaa guggauggcu uuagaaagca uccucaggcg acgcuucacu     2700

caucaguccg acgugugguc auauggcguu acaguguggg agcugaugac cuuuggggcc     2760

aaaccuuacg auggcauucc ggcacgggag auaccagacc uucuggaaaa gggagagaga     2820

uugccccagc cuccaaucug cacaauugau guauauauga ucauggucaa auguuggaug     2880

auugacagug aaugcaggcc ccguuuccgc gagcucgugu cugaauuuag ccggauggcg     2940

agagacccuc aaagguucgu ggucauccag aaugaggauc uggggccggc cucuccccua     3000

gacucaacuu uuuaccgaag ccugcuugag gaugacgaua ugggagaccu cguugaugcu     3060

gaagaguacc uggugccaca gcagggcuuc uuuuguccug accccgcccc aggugcaggg     3120

ggaaugguac accaccggca ucgcuccucc aguaccagaa gcggcggugg cgauuugacg     3180

cugggguuag aaccuucuga ggaggaagcu cccagguccc cacucgcccc gucagaggga     3240

gcaggcagug acguguucga uggggaccug ggaaugggcg ccgcuaaggg ucuucaaagc     3300

cugccuaccc acgaucccuc gccauugcag cgguauuccg aagaccccac agucccucuc     3360

ccaucugaga cugacgggua cguggcgccc cugaccugca gcccucagcc ggaauauguu     3420

aaccagccag augugcgacc ccaaccuccc ucaccaagag agggaccucu acccgccgca     3480

cgcccagcug gcgccacacu ggagaggccu aaaacucuua guccggguaa gaauggcguc     3540

gugaaggacg uuuucgccuu ugggggagcu guggaaaacc ccgaguaccu caccccacag     3600

ggcggggcag ccccucagcc ccauccaccu cccgcguucu ccccggcuuu ugauaaucug     3660

uauuacuggg accaggaucc accugaacgu ggagcacccc caucuacguu caaaggcaca     3720

cccaccgccg agaacccuga auauuugggu uuagacgucc cgguauga                  3768


<210>  1887
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Her2/neu__Homo_sapiens__AAI67147

<400>  1887
auggagcugg ccgcccugug cagauggggc cugcugcugg cccugcugcc ccccggcgcc       60

gccagcaccc aggugugcac cggcaccgac augaagcuga gacugcccgc cagccccgag      120

acccaccugg acaugcugag acaccuguac cagggcugcc agguggugca gggcaaccug      180

gagcugaccu accugcccac caacgccagc cugagcuucc ugcaggacau ccaggaggug      240

cagggcuacg ugcugaucgc ccacaaccag gugagacagg ugccccugca gagacugaga      300

aucgugagag gcacccagcu guucgaggac aacuacgccc uggccgugcu ggacaacggc      360

gacccccuga acaacaccac ccccgugacc ggcgccagcc ccggcggccu gagagagcug      420

cagcugagaa gccugaccga gauccugaag ggcggcgugc ugauccagag aaacccccag      480

cugugcuacc aggacaccau ccuguggaag gacaucuucc acaagaacaa ccagcuggcc      540

cugacccuga ucgacaccaa cagaagcaga gccugccacc ccugcagccc caugugcaag      600

ggcagcagau gcuggggcga gagcagcgag gacugccaga gccugaccag aaccgugugc      660

gccggcggcu gcgccagaug caagggcccc cugcccaccg acugcugcca cgagcagugc      720

gccgccggcu gcaccggccc caagcacagc gacugccugg ccugccugca cuucaaccac      780

agcggcaucu gcgagcugca cugccccgcc cuggugaccu acaacaccga caccuucgag      840

agcaugccca accccgaggg cagauacacc uucggcgcca gcugcgugac cgccugcccc      900

uacaacuacc ugagcaccga cgugggcagc ugcacccugg ugugcccccu gcacaaccag      960

gaggugaccg ccgaggacgg cacccagaga ugcgagaagu gcagcaagcc cugcgccaga     1020

gugugcuacg gccugggcau ggagcaccug agagagguga gagccgugac cagcgccaac     1080

auccaggagu ucgccggcug caagaagauc uucggcagcc uggccuuccu gcccgagagc     1140

uucgacggcg accccgccag caacaccgcc ccccugcagc ccgagcagcu gcagguguuc     1200

gagacccugg aggagaucac cggcuaccug uacaucagcg ccuggcccga cagccugccc     1260

gaccugagcg uguuccagaa ccugcaggug aucagaggca gaauccugca caacggcgcc     1320

uacagccuga cccugcaggg ccugggcauc agcuggcugg gccugagaag ccugagagag     1380

cugggcagcg gccuggcccu gauccaccac aacacccacc ugugcuucgu gcacaccgug     1440

cccugggacc agcuguucag aaacccccac caggcccugc ugcacaccgc caacagaccc     1500

gaggacgagu gcgugggcga gggccuggcc ugccaccagc ugugcgccag aggccacugc     1560

uggggccccg gccccaccca gugcgugaac ugcagccagu uccugagagg ccaggagugc     1620

guggaggagu gcagagugcu gcagggccug cccagagagu acgugaacgc cagacacugc     1680

cugcccugcc accccgagug ccagccccag aacggcagcg ugaccugcuu cggccccgag     1740

gccgaccagu gcguggccug cgcccacuac aaggaccccc ccuucugcgu ggccagaugc     1800

cccagcggcg ugaagcccga ccugagcuac augcccaucu ggaaguuccc cgacgaggag     1860

ggcgccugcc agcccugccc caucaacugc acccacagcu gcguggaccu ggacgacaag     1920

ggcugccccg ccgagcagag agccagcccc cugaccagca ucaucagcgc cguggugggc     1980

auccugcugg ugguggugcu gggcguggug uucggcaucc ugaucaagag aagacagcag     2040

aagaucagaa aguacaccau gagaagacug cugcaggaga ccgagcuggu ggagccccug     2100

acccccagcg gcgccaugcc caaccaggcc cagaugagaa uccugaagga gaccgagcug     2160

agaaagguga aggugcuggg cagcggcgcc uucggcaccg uguacaaggg caucuggauc     2220

cccgacggcg agaacgugaa gauccccgug gccaucaagg ugcugagaga gaacaccagc     2280

cccaaggcca acaaggagau ccuggacgag gccuacguga uggccggcgu gggcagcccc     2340

uacgugagca gacugcuggg caucugccug accagcaccg ugcagcuggu gacccagcug     2400

augcccuacg gcugccugcu ggaccacgug agagagaaca gaggcagacu gggcagccag     2460

gaccugcuga acuggugcau gcagaucgcc aagggcauga gcuaccugga ggacgugaga     2520

cuggugcaca gagaccuggc cgccagaaac gugcugguga agagccccaa ccacgugaag     2580

aucaccgacu ucggccuggc cagacugcug gacaucgacg agaccgagua ccacgccgac     2640

ggcggcaagg ugcccaucaa guggauggcc cuggagagca uccugagaag aagauucacc     2700

caccagagcg acguguggag cuacggcgug accguguggg agcugaugac cuucggcgcc     2760

aagcccuacg acggcauccc cgccagagag auccccgacc ugcuggagaa gggcgagaga     2820

cugccccagc cccccaucug caccaucgac guguacauga ucauggugaa gugcuggaug     2880

aucgacagcg agugcagacc cagauucaga gagcugguga gcgaguucag cagaauggcc     2940

agagaccccc agagauucgu ggugauccag aacgaggacc ugggccccgc cagcccccug     3000

gacagcaccu ucuacagaag ccugcuggag gacgacgaca ugggcgaccu gguggacgcc     3060

gaggaguacc uggugcccca gcagggcuuc uucugccccg accccgcccc cggcgccggc     3120

ggcauggugc accacagaca cagaagcagc agcaccagaa gcggcggcgg cgaccugacc     3180

cugggccugg agcccagcga ggaggaggcc cccagaagcc cccuggcccc cagcgagggc     3240

gccggcagcg acguguucga cggcgaccug ggcaugggcg ccgccaaggg ccugcagagc     3300

cugcccaccc acgaccccag cccccugcag agauacagcg aggaccccac cgugccccug     3360

cccagcgaga ccgacggcua cguggccccc cugaccugca gcccccagcc cgaguacgug     3420

aaccagcccg acgugagacc ccagcccccc agccccagag agggcccccu gcccgccgcc     3480

agacccgccg gcgccacccu ggagagaccc aagacccuga gccccggcaa gaacggcgug     3540

gugaaggacg uguucgccuu cggcggcgcc guggagaacc ccgaguaccu gaccccccag     3600

ggcggcgccg ccccccagcc ccaccccccc cccgccuuca gccccgccuu cgacaaccug     3660

uacuacuggg accaggaccc ccccgagaga ggcgcccccc ccagcaccuu caagggcacc     3720

cccaccgccg agaaccccga guaccugggc cuggacgugc ccguguga                  3768


<210>  1888
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Her2/neu__Homo_sapiens__AAI67147

<400>  1888
auggagcugg ccgcucucug ccgguggggc cugcuucugg cccuccugcc cccuggggcg       60

gcuagcaccc agguguguac aggaacggac augaagcugc ggcuuccggc cucccccgaa      120

acccaccucg auaugcugcg ccaucuguac caaggcugcc aggucguuca ggggaaccuc      180

gagcugacau aucuuccuac caaugccucu cugagcuucc uccaggacau ccaagaagug      240

cagggauacg ugcugauugc ucacaaccag gucagacagg ugccccuuca acggcugcgc      300

aucguuagag gcacacagcu cuuugaggau aauuaugccc uggcugugcu ggacaacggg      360

gauccucuca auaacaccac acccgucacc ggagccuccc cuggcggccu gcgggaacuu      420

cagcugcgcu cucucacgga gauucugaaa gggggagugc uuauccagag aaauccgcaa      480

cuguguuacc aggacaccau ucucuggaag gauaucuucc auaaaaacaa ucagcuggcg      540

cugacacuca ucgacaccaa ccggagccgc gccugccacc ccuguucccc uaugugcaag      600

ggcucuagau guuggggaga gagcuccgaa gauugccaaa gccugacacg gaccguuugu      660

gcugggggcu gcgcccgcug uaaagggccc cuuccuacgg acugcugcca ugagcagugu      720

gcugccggau gcacaggccc caagcacucu gauugucugg cgugccucca cuuuaaucau      780

uccggcauuu gugaacugca cugcccggcc cuugugaccu auaacacaga caccuucgag      840

agcaugccua aucccgaggg gagauacacc uuuggagcuu cuugugucac agccugcccu      900

uauaacuacc uguccacgga ugugggcagc uguacccucg ugugcccccu gcauaaucag      960

gaagucacag cugaggacgg gacccagcgg ugugaaaagu gcucuaaacc cugcgcccgc     1020

guuuguuacg gacugggcau ggagcaccuc agagaagugc gggccgugac auccgcuaac     1080

auccaagagu ucgcggggug caagaaaauu uuuggaagcc uggccuuccu uccugagucc     1140

uuugacggcg auccggcuuc uaacaccgcu ccccugcagc cugaacagcu ccaggucuuc     1200

gagacgcugg aagagaucac aggcuaucug uacauuagcg ccuggcccga cucccuuccu     1260

gaucucagcg uguuucaaaa ucugcagguu aucagagggc gcauucugca caacggagcc     1320

uauucucuca cccugcaggg ccuugggauc uccuggcugg gacuccggag ccugagagaa     1380

cugggcucug ggcuugcccu cauccaucac aauacccauc uguguuucgu gcacacaguc     1440

cccugggacc agcuguuucg caacccgcau caagcgcucc ugcacaccgc uaaucggccu     1500

gaggaugagu gcgugggcga aggacuugcc ugucaccagc ugugcgccag aggccauugu     1560

ugggggcccg gaccuacaca gugcguuaac uguagccagu uccuccgcgg ccaagagugc     1620

guggaagagu gucggguccu gcaggggcug cccagagaau acgugaaugc ucgccacugc     1680

cuuccuugcc aucccgagug ucagccgcaa aacggauccg ucacgugcuu cggcccugag     1740

gccgaccagu guguggcuug cgcccacuau aaggauccuc ccuuuugugu ugcgcggugc     1800

cccucugggg ugaaaccgga ccucagcuac augcccauuu ggaaguuccc ugaugaagag     1860

ggcgccuguc agcccugccc uaucaauugu acccacuccu gcgucgaccu ggaugacaag     1920

ggaugucccg cugaacagag agccagcccu cugacaucua uuaucuccgc ugugguuggc     1980

auucuccugg uggucgugcu uggggugguu uuuggaaucc ugaucaaacg ccggcaacag     2040

aagauuagaa aauauaccau gcggcgccuc cugcaggaga cagagcuggu cgaaccccuu     2100

accccgagcg gcgccaugcc uaaccaggcg caaaugagaa uccucaagga gacggaacug     2160

cggaaaguga aggugcuggg gucuggagcc uucggcaccg ucuacaaagg gauuuggauc     2220

cccgacggcg agaaugugaa gauuccuguu gcuaucaagg ugcucagaga aaacacaucc     2280

cccaaagcca auaaggagau ccuggaugag gcuuacguca uggccggagu gggcagcccg     2340

uauguuuccc gccuucuggg gauuugccuc accucuacag ugcagcuggu cacccagcug     2400

augccuuacg gaugccuucu ggaccaugug cgggaaaaca gaggccgccu cgggagccag     2460

gaucugcuca auugguguau gcaaaucgcc aaaggaaugu ccuaucugga ggacguuaga     2520

cuugugcacc gggaucuggc ugcgcgcaac guccucguga agucucccaa ccaugugaaa     2580

auuacggacu uuggccuggc cagacugcuu gauaucgacg aaacagagua ccacgcugau     2640

gggggcaagg ucccuauuaa guggauggcc cuggaaagca uccuccggcg cagauucacc     2700

caucaguccg acguuuggag cuauggagug acaguguggg agcugaugac cuuuggcgcc     2760

aaacccuacg augggauucc cgcucgggag aucccugacc uccuggaaaa gggagagcgc     2820

cuuccgcagc ccccuaucug caccauugau gucuauauga ucauggugaa auguuggaug     2880

auugacucug aaugcagacc ccgguuccgc gagcugguuu ccgaauuuag cagaauggcc     2940

cgggacccuc aaagauucgu ggucauccag aaugaggauc ucggccccgc gucuccucug     3000

gacuccacau uuuaccgcag ccugcuugag gaugacgaua ugggggaccu gguggaugcu     3060

gaagaguacc ucguuccgca gcagggauuc uuuugucccg acccugcccc cggcgccggc     3120

gggauggugc accaccggca uagaucuagc uccacgcgca gcggaggcgg ggaucugacc     3180

cucggacugg aaccuucuga ggaggaagcu ccccgguccc cgcuugcccc uagcgagggc     3240

gcgggguccg acgucuucga uggagaccug ggcaugggcg cugccaaggg gcugcaaucu     3300

cuccccacac acgaucccag cccucugcag agauauuccg aagaccccac cgugccucuu     3360

ccgucugaga cagacggaua cguugcuccc cugaccugca gcccucagcc cgaauaugug     3420

aaccagccug auguccgccc ccaaccgccu ucuccccggg agggcccucu ccccgccgcc     3480

agaccugcug gggccacgcu ggagcgcccc aaaacacucu ccccgggaaa gaauggcgug     3540

gugaaggacg ucuucgcguu ugggggagcc guugaaaacc cugaguaccu gacaccccag     3600

ggcggcgcug cuccccagcc ucauccgccc ccugccuuca gccccgccuu ugauaaucuu     3660

uauuacuggg accaggaucc ucccgaaaga ggggccccuc cguccaccuu caaaggaacc     3720

cccaccgcug agaacccuga auaucugggc cuggacgugc ccguguga                  3768


<210>  1889
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__Q9UK79

<400>  1889

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Gly Thr His Ser Leu Pro Pro Arg Pro Ala Ala Val 
            340                 345                 350         


Pro Val Pro Leu Arg Met Gln Pro Gly Pro Ala His Pro Val Leu Ser 
        355                 360                 365             


Phe Leu Arg Pro Ser Trp Asp Leu Val Ser Ala Phe Tyr Ser Leu Pro 
    370                 375                 380                 


Leu Ala Pro Leu Ser Pro Thr Ser Val Pro Ile Ser Pro Val Ser Val 
385                 390                 395                 400 


Gly Arg Gly Pro Asp Pro Asp Ala His Val Ala Val Asp Leu Ser Arg 
                405                 410                 415     


Tyr Glu Gly 
            


<210>  1890
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Her2/neu__Homo_sapiens__AAD56009

<400>  1890
auggagcugg cggccuugug ccgcuggggg cuccuccucg cccucuugcc ccccggagcc       60

gcgagcaccc aagugugcac cggcacagac augaagcugc ggcucccugc cagucccgag      120

acccaccugg acaugcuccg ccaccucuac cagggaugcc agguggugca gggaaaccug      180

gaacucaccu accugcccac caaugccagc cuguccuucc ugcaggauau ccaggaggug      240

cagggcuacg ugcucaucgc ucacaaccaa gugaggcagg ucccacugca gaggcugcgg      300

auugugcgag gcacccagcu cuuugaggac aacuaugccc uggccgugcu agacaaugga      360

gacccgcuga acaauaccac cccugucaca ggggccuccc caggaggccu gcgggagcug      420

cagcuucgaa gccucacaga gaucuugaaa ggaggggucu ugauccagcg gaacccccag      480

cucugcuacc aggacacgau uuuguggaag gacaucuucc acaagaacaa ccagcuggcu      540

cucacacuga uagacaccaa ccgcucucgg gccugccacc ccugcucucc gauguguaag      600

ggcucccgcu gcuggggaga gaguucugag gauugucaga gccugacgcg cacugucugu      660

gccgguggcu gugcccgcug caaggggcca cugcccacug acugcugcca ugagcagugu      720

gcugccggcu gcacgggccc caagcacucu gacugccugg ccugccucca cuucaaccac      780

aguggcaucu gugagcugca cugcccagcc cuggucaccu acaacacaga cacguuugag      840

uccaugccca aucccgaggg ccgguauaca uucggcgcca gcugugucac ugccuguccc      900

uacaacuacc uuucuacgga cgugggaucc ugcacccucg ucugcccccu gcacaaccaa      960

gaggugacag cagaggaugg aacacagcgg ugugagaagu gcagcaagcc cugugcccga     1020

gguacccacu cacugccccc gaggccagcu gcaguuccug ucccucugcg caugcagccu     1080

ggcccagccc acccuguccu auccuuccuc agacccucuu gggaccuagu cucugccuuc     1140

uacucucuac cccuggcccc ccucagcccu acaagugucc cuauaucccc ugucagugug     1200

gggaggggcc cggacccuga ugcucaugug gcuguugacc ugucccggua ugaaggcuga     1260


<210>  1891
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Her2/neu__Homo_sapiens__AAD56009

<400>  1891
auggagcugg ccgcccucug ccgcuggggc cugcugcucg cccugcugcc cccgggggcc       60

gccagcaccc aggugugcac cggcacggac augaagcucc ggcugcccgc cucccccgag      120

acccaccugg acaugcuccg ccaccuguac caggggugcc aggucgugca gggcaaccug      180

gagcucaccu accugcccac caacgccagc cuguccuucc uccaggacau ccaggaggug      240

cagggguacg uccugaucgc gcacaaccag gugcgccagg ugccgcugca gcggcuccgg      300

aucguccgcg gcacgcagcu guucgaggac aacuacgccc uggccgugcu cgacaacggc      360

gacccccuga acaacaccac ccccgugacc ggggccagcc ccggcgggcu gcgggagcuc      420

cagcugcgcu cccugacgga gauccucaag ggcggggucc ugauccagcg gaacccgcag      480

cugugcuacc aggacaccau ccucuggaag gacaucuucc acaagaacaa ccagcuggcg      540

cugacccuca ucgacaccaa ccgcagccgg gccugccacc ccugcucccc caugugcaag      600

ggcagccgcu gcuggggcga guccagcgag gacugccagu cccugacgcg gaccgugugc      660

gccgggggcu gcgcccgcug caaggggccc cugccgaccg acugcugcca cgagcagugc      720

gccgcgggcu gcaccggccc caagcacagc gacugccucg ccugccugca cuucaaccac      780

uccgggaucu gcgagcugca cugccccgcc cucgugacgu acaacaccga caccuucgag      840

agcaugccca acccggaggg ccgguacacc uucggggccu ccugcgucac ggccugcccc      900

uacaacuacc ugagcaccga cgugggcucc ugcacccugg ugugcccccu ccacaaccag      960

gaggucaccg cggaggacgg gacgcagcgc ugcgagaagu gcagcaagcc cugcgcccgg     1020

ggcacccacu cccugccgcc ccgccccgcc gccgugcccg ugccgcugcg gaugcagccc     1080

ggccccgccc accccguccu cagcuuccug cgcccgagcu gggaccuggu guccgcguuc     1140

uacagccucc cccuggcgcc ccuguccccg accagcgugc ccaucucccc cgucagcgug     1200

gggcggggcc ccgacccgga cgcccacgug gccgucgacc ugucccgcua cgagggguga     1260


<210>  1892
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Her2/neu__Homo_sapiens__AAD56009

<400>  1892
auggagcucg ccgcccucug ccgcuggggc cuccuccucg cccuccuccc ccccggcgcc       60

gccuccaccc aggucugcac cggcaccgac augaagcucc gccuccccgc cucccccgag      120

acccaccucg acaugcuccg ccaccucuac cagggcugcc aggucgucca gggcaaccuc      180

gagcucaccu accuccccac caacgccucc cucuccuucc uccaggacau ccaggagguc      240

cagggcuacg uccucaucgc ccacaaccag guccgccagg ucccccucca gcgccuccgc      300

aucguccgcg gcacccagcu cuucgaggac aacuacgccc ucgccguccu cgacaacggc      360

gacccccuca acaacaccac ccccgucacc ggcgccuccc ccggcggccu ccgcgagcuc      420

cagcuccgcu cccucaccga gauccucaag ggcggcgucc ucauccagcg caacccccag      480

cucugcuacc aggacaccau ccucuggaag gacaucuucc acaagaacaa ccagcucgcc      540

cucacccuca ucgacaccaa ccgcucccgc gccugccacc ccugcucccc caugugcaag      600

ggcucccgcu gcuggggcga guccuccgag gacugccagu cccucacccg caccgucugc      660

gccggcggcu gcgcccgcug caagggcccc cuccccaccg acugcugcca cgagcagugc      720

gccgccggcu gcaccggccc caagcacucc gacugccucg ccugccucca cuucaaccac      780

uccggcaucu gcgagcucca cugccccgcc cucgucaccu acaacaccga caccuucgag      840

uccaugccca accccgaggg ccgcuacacc uucggcgccu ccugcgucac cgccugcccc      900

uacaacuacc ucuccaccga cgucggcucc ugcacccucg ucugcccccu ccacaaccag      960

gaggucaccg ccgaggacgg cacccagcgc ugcgagaagu gcuccaagcc cugcgcccgc     1020

ggcacccacu cccucccccc ccgccccgcc gccguccccg ucccccuccg caugcagccc     1080

ggccccgccc accccguccu cuccuuccuc cgccccuccu gggaccucgu cuccgccuuc     1140

uacucccucc cccucgcccc ccucuccccc accuccgucc ccaucucccc cgucuccguc     1200

ggccgcggcc ccgaccccga cgcccacguc gccgucgacc ucucccgcua cgagggcuga     1260


<210>  1893
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Her2/neu__Homo_sapiens__AAD56009

<400>  1893
auggagcugg ccgcucucug cagauggggc cuucuguugg cauuacugcc cccuggggcc       60

gcgagcaccc agguguguac aggaacugac augaagcuaa ggcucccagc uuccccggaa      120

acgcaccugg auaugcuucg gcaucuguac caagguugcc aggucguuca gggcaacuug      180

gagcucaccu aucugcccac aaaugccucu cugucauucc uccaggacau ccaagaagug      240

cagggguacg uauuaauugc acacaaccag gugcgccagg ucccucugca acgacuucgu      300

auagugagag gaacucaguu guuugaggau aauuaugccc uggcuguucu agacaacggc      360

gauccacuca auaacaccac acccgugacc ggugcaaguc cugggggacu gagggaacuu      420

cagcugcgga gcuugacuga gauccucaaa ggcggcgucc ugauucagcg caauccacaa      480

uuauguuacc aggacacaau ccuguggaag gauauuuucc auaaaaacaa ucagcucgcc      540

cuuacccuga ucgacacgaa cagauccagg gcuugccacc ccuguucucc uaugugcaag      600

gggucgcggu guuggggaga gucaagcgaa gauugccaaa guuugacucg caccgugugu      660

gccgguggcu gcgcgcgaug uaaagggcca cuaccgacag acugcugcca ugagcagugu      720

gcagccggau gcacuggccc caagcacucc gauugucugg cuugccucca cuuuaaucau      780

ucugguauau gugaacugca cugcccugcc cuuguaaccu auaacacaga caccuucgag      840

agcaugccaa aucccgaggg gagauacacg uuuggagcau ccuguguuac ugcuugcccu      900

uauaacuacc ugucaacaga ugugggcagu uguaccuugg ucugcccacu ccauaaucag      960

gaagugacug ccgaggacgg cacacagagg ugugaaaagu gcagcaaacc cugcgcgcgg     1020

gggacccacu cucugccgcc ucgucccgcc gcagugccag ucccuuuacg caugcaaccc     1080

ggaccagcuc accccguucu guccuuccua agaccuucau gggaccucgu gagcgccuuu     1140

uacagucugc cacuugcucc guugucuccc acguccguac cuaucagccc agugucgguc     1200

gguaggggcc ccgauccuga cgcccaugug gcaguugauc ugucucggua ugagggguga     1260


<210>  1894
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Her2/neu__Homo_sapiens__AAD56009

<400>  1894
auggagcugg ccgcccugug cagauggggc cugcugcugg cccugcugcc ccccggcgcc       60

gccagcaccc aggugugcac cggcaccgac augaagcuga gacugcccgc cagccccgag      120

acccaccugg acaugcugag acaccuguac cagggcugcc agguggugca gggcaaccug      180

gagcugaccu accugcccac caacgccagc cugagcuucc ugcaggacau ccaggaggug      240

cagggcuacg ugcugaucgc ccacaaccag gugagacagg ugccccugca gagacugaga      300

aucgugagag gcacccagcu guucgaggac aacuacgccc uggccgugcu ggacaacggc      360

gacccccuga acaacaccac ccccgugacc ggcgccagcc ccggcggccu gagagagcug      420

cagcugagaa gccugaccga gauccugaag ggcggcgugc ugauccagag aaacccccag      480

cugugcuacc aggacaccau ccuguggaag gacaucuucc acaagaacaa ccagcuggcc      540

cugacccuga ucgacaccaa cagaagcaga gccugccacc ccugcagccc caugugcaag      600

ggcagcagau gcuggggcga gagcagcgag gacugccaga gccugaccag aaccgugugc      660

gccggcggcu gcgccagaug caagggcccc cugcccaccg acugcugcca cgagcagugc      720

gccgccggcu gcaccggccc caagcacagc gacugccugg ccugccugca cuucaaccac      780

agcggcaucu gcgagcugca cugccccgcc cuggugaccu acaacaccga caccuucgag      840

agcaugccca accccgaggg cagauacacc uucggcgcca gcugcgugac cgccugcccc      900

uacaacuacc ugagcaccga cgugggcagc ugcacccugg ugugcccccu gcacaaccag      960

gaggugaccg ccgaggacgg cacccagaga ugcgagaagu gcagcaagcc cugcgccaga     1020

ggcacccaca gccugccccc cagacccgcc gccgugcccg ugccccugag aaugcagccc     1080

ggccccgccc accccgugcu gagcuuccug agacccagcu gggaccuggu gagcgccuuc     1140

uacagccugc cccuggcccc ccugagcccc accagcgugc ccaucagccc cgugagcgug     1200

ggcagaggcc ccgaccccga cgcccacgug gccguggacc ugagcagaua cgagggcuga     1260


<210>  1895
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Her2/neu__Homo_sapiens__AAD56009

<400>  1895
auggagcugg ccgcucucug cagauggggc cugcuucugg cccuccugcc cccuggggcg       60

gcuagcaccc agguguguac aggaacggac augaagcugc ggcuuccggc cucccccgaa      120

acccaccucg auaugcugcg ccaucuguac caaggcugcc aggucguuca ggggaaccuc      180

gagcugacau aucuuccuac caaugccucu cugagcuucc uccaggacau ccaagaagug      240

cagggauacg ugcugauugc ucacaaccag gucagacagg ugccccuuca acggcugcgc      300

aucguuagag gcacacagcu cuuugaggau aauuaugccc uggcugugcu ggacaacggg      360

gauccucuca auaacaccac acccgucacc ggagccuccc cuggcggccu gcgggaacuu      420

cagcugcgcu cucucacgga gauucugaaa gggggagugc uuauccagag aaauccgcaa      480

cuguguuacc aggacaccau ucucuggaag gauaucuucc auaaaaacaa ucagcuggcg      540

cugacacuca ucgacaccaa ccggagccgc gccugccacc ccuguucccc uaugugcaag      600

ggcucuagau guuggggaga gagcuccgaa gauugccaaa gccugacacg gaccguuugu      660

gcugggggcu gcgcccgcug uaaagggccc cuuccuacgg acugcugcca ugagcagugu      720

gcugccggau gcacaggccc caagcacucu gauugucugg cgugccucca cuuuaaucau      780

uccggcauuu gugaacugca cugcccggcc cuugugaccu auaacacaga caccuucgag      840

agcaugccua aucccgaggg gagauacacc uuuggagcuu cuugugucac agccugcccu      900

uauaacuacc uguccacgga ugugggcagc uguacccucg ugugcccccu gcauaaucag      960

gaagucacag cugaggacgg gacccagcgg ugugaaaagu gcucuaaacc cugcgcccgc     1020

ggaacacacu cccugccucc gagacccgcc gcuguuccug ugccccuccg gaugcaaccu     1080

ggccccgcgc acccggugcu gagcuuccuu agaccuuccu gggaccuggu cucugccuuu     1140

uacagccucc cccuggcucc ucuguccccc accagcgugc cuaucucucc cguuuccgug     1200

gggcgcggac cggauccuga cgcccauguc gccguggauc uuagccggua ugagggcuga     1260


<210>  1896
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A2/m__Homo_sapiens__Q95387

<400>  1896

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Thr Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  1897
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A2/m__Homo_sapiens__U70863.1

<400>  1897
ggcucucacu ccaugaggua uuucuucaca uccguguccc ggcccggccg cggggagccc       60

cgcuucaucg cagugggcua cguggacgac acgcaguucg ugcgguucga cagcgacgcc      120

gcgagccaga ggauggagcc gcgggcgccg uggauagagc aggagggucc ggaguauugg      180

gacggggaga cacggaaagu gaaggcccac ucacagacuc accgagugga ccuggggacc      240

cugcgcggcu acuacaacca gagcgaggcc gguucucaca ccguccagag gauguauggc      300

ugcgacgugg ggucggacug gcgcuuccuc cgcggguacc accaguacgc cuacgacggc      360

aaggauuaca ucgcccugaa agaggaccug cgcucuugga ccgcggcgga cauggcagcu      420

cagaccacca agcacaagug ggagacggcc cauguggcgg agcaguugag agccuaccug      480

gagggcacgu gcguggagug gcuccgcaga uaccuggaga acgggaagga gacgcugcag      540

cgcacg                                                                 546


<210>  1898
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HLA-A2/m__Homo_sapiens__U70863.1

<400>  1898
ggcagccacu ccaugcgcua cuucuucacc agcguguccc ggcccgggcg cggcgagccg       60

cgguucaucg ccgucgggua cguggacgac acccaguucg ugcgcuucga cagcgacgcc      120

gcgucccagc ggauggagcc ccgcgccccc uggaucgagc aggagggccc cgaguacugg      180

gacggggaga cgcggaaggu caaggcccac agccagaccc accgcgugga ccugggcacc      240

cuccggggcu acuacaacca guccgaggcc gggagccaca ccgugcagcg cauguacggc      300

ugcgacgucg gguccgacug gcgguuccug cgcggcuacc accaguacgc cuacgacggg      360

aaggacuaca ucgcgcugaa ggaggaccuc cggagcugga cggccgccga cauggccgcg      420

cagaccacca agcacaagug ggagaccgcc cacguggccg agcagcugcg cgccuaccug      480

gagggcacgu gcguggagug gcuccggcgc uaccuggaga acggcaagga gacccugcag      540

cggacc                                                                 546


<210>  1899
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HLA-A2/m__Homo_sapiens__U70863.1

<400>  1899
ggcucccacu ccaugcgcua cuucuucacc uccgucuccc gccccggccg cggcgagccc       60

cgcuucaucg ccgucggcua cgucgacgac acccaguucg uccgcuucga cuccgacgcc      120

gccucccagc gcauggagcc ccgcgccccc uggaucgagc aggagggccc cgaguacugg      180

gacggcgaga cccgcaaggu caaggcccac ucccagaccc accgcgucga ccucggcacc      240

cuccgcggcu acuacaacca guccgaggcc ggcucccaca ccguccagcg cauguacggc      300

ugcgacgucg gcuccgacug gcgcuuccuc cgcggcuacc accaguacgc cuacgacggc      360

aaggacuaca ucgcccucaa ggaggaccuc cgcuccugga ccgccgccga cauggccgcc      420

cagaccacca agcacaagug ggagaccgcc cacgucgccg agcagcuccg cgccuaccuc      480

gagggcaccu gcgucgagug gcuccgccgc uaccucgaga acggcaagga gacccuccag      540

cgcacc                                                                 546


<210>  1900
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HLA-A2/m__Homo_sapiens__U70863.1

<400>  1900
ggcagccacu ccaugagaua cuucuuuacc ucugugucaa ggcccgggcg gggagagccu       60

cgcuucaucg ccgucgguua uguugacgau acacaguuug ugcgauucga cagugaugcu      120

gcaagccaac guauggaacc aagagccccg uggauugagc aggaaggccc cgaguacugg      180

gacggggaaa cuaggaaggu aaaagcgcau ucccagacgc accgggugga ucugggaacc      240

cuccgcggcu auuacaacca gucugaggcu gguucgcaua caguccaaag aauguauggg      300

ugcgacgugg gaucagauug gagguuucuu cggggcuacc accaguaugc cuacgacggc      360

aaggauuaca uagcacugaa agaggacuug cgcagcugga cugccgcuga uauggcagcc      420

cagaccacaa agcauaaaug ggaaaccgcu cacguugccg agcaguuacg agcguaucug      480

gaagggacuu guguggagug gcuaagaagg uaccucgaga auggaaagga aacacugcaa      540

cggacc                                                                 546


<210>  1901
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HLA-A2/m__Homo_sapiens__U70863.1

<400>  1901
ggcagccaca gcaugagaua cuucuucacc agcgugagca gacccggcag aggcgagccc       60

agauucaucg ccgugggcua cguggacgac acccaguucg ugagauucga cagcgacgcc      120

gccagccaga gaauggagcc cagagccccc uggaucgagc aggagggccc cgaguacugg      180

gacggcgaga ccagaaaggu gaaggcccac agccagaccc acagagugga ccugggcacc      240

cugagaggcu acuacaacca gagcgaggcc ggcagccaca ccgugcagag aauguacggc      300

ugcgacgugg gcagcgacug gagauuccug agaggcuacc accaguacgc cuacgacggc      360

aaggacuaca ucgcccugaa ggaggaccug agaagcugga ccgccgccga cauggccgcc      420

cagaccacca agcacaagug ggagaccgcc cacguggccg agcagcugag agccuaccug      480

gagggcaccu gcguggagug gcugagaaga uaccuggaga acggcaagga gacccugcag      540

agaacc                                                                 546


<210>  1902
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HLA-A2/m__Homo_sapiens__U70863.1

<400>  1902
ggcagccacu ccaugagaua cuucuuuacc ucugugagcc ggcccgggcg cggagagccu       60

agauucaucg ccgucggcua uguugacgau acacaguuug ugcgguucga cuccgaugcu      120

gccucucaac gcauggaacc gagagcgccc uggauugagc aggaagggcc ugaguacugg      180

gacggagaaa cgcggaaggu gaaagcucau agccagaccc accgcgucga ucugggcaca      240

cucagagggu auuacaacca guccgaggcc ggaucucaua ccgugcaacg gauguauggc      300

ugcgacguug gcagcgauug gcgcuuucug agaggguacc accaguaugc cuacgacgga      360

aaggauuaca ucgcucuuaa agaggaccug cgguccugga cagccgcuga uauggccgcg      420

cagaccacaa agcauaaaug ggaaaccgcc cacguggcug agcagcuccg cgccuaucug      480

gaaggcacgu gugucgagug gcuuagacgg uaccuggaga augggaagga aacccuccaa      540

cgcaca                                                                 546


<210>  1903
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA-A2/m__Homo_sapiens__Q9MYF8

<400>  1903

Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg 
    50                  55                  60                  


Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys His 
    130                 135                 140                 


Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Thr 
            180     


<210>  1904
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1904
ucucacucca ugagguauuu cuucacaucc gugucccggc ccggccgcgg ggagccccgc       60

uucaucgcag ugggcuacgu ggacgacacg caguucgugc gguucgacag cgacgccgcg      120

agccagagga uggagccgcg ggcgccgugg auagagcagg aggguccgga guauugggac      180

ggggagacac ggaaagugaa ggcccacuca cagacucacc gaguggaccu ggggacccug      240

cgcggcuacu acaaccagag cgaggccggu ucucacaccg uccagaggau guauggcugc      300

gacguggggu cggacuggcg cuuccuccgc ggguaccacc aguacgccua cgacggcaag      360

gauuacaucg cccugaaaga agaccugcgc ucuuggaccg cggcggacau ggcagcucag      420

accaccaagc acaaguggga ggcggcccau guggcggagc aguugagagc cuaccuggag      480

ggcacgugcg uggaguggcu ccgcagauac cuggagaacg ggaaggagac gcugcagcgc      540

acg                                                                    543


<210>  1905
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1905
agccacucca ugcgcuacuu cuucaccagc gugucccggc ccggccgcgg ggagccgcgg       60

uucaucgccg ucggcuacgu ggacgacacc caguucgugc gcuucgacag cgacgccgcg      120

ucccagcgga uggagccccg cgcccccugg aucgagcagg aggggcccga guacugggac      180

ggcgagacgc ggaaggucaa ggcccacagc cagacccacc gcguggaccu ggggacccuc      240

cggggcuacu acaaccaguc cgaggccggc agccacaccg ugcagcgcau guacgggugc      300

gacgucggcu ccgacuggcg guuccugcgc ggguaccacc aguacgccua cgacggcaag      360

gacuacaucg cgcugaagga ggaccuccgg agcuggacgg ccgccgacau ggccgcgcag      420

accaccaagc acaaguggga ggccgcccac guggccgagc agcugcgcgc cuaccuggag      480

gggaccugcg uggaguggcu ccggcgcuac cuggagaacg gcaaggagac gcugcagcgg      540

acc                                                                    543


<210>  1906
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1906
ucccacucca ugcgcuacuu cuucaccucc gucucccgcc ccggccgcgg cgagccccgc       60

uucaucgccg ucggcuacgu cgacgacacc caguucgucc gcuucgacuc cgacgccgcc      120

ucccagcgca uggagccccg cgcccccugg aucgagcagg agggccccga guacugggac      180

ggcgagaccc gcaaggucaa ggcccacucc cagacccacc gcgucgaccu cggcacccuc      240

cgcggcuacu acaaccaguc cgaggccggc ucccacaccg uccagcgcau guacggcugc      300

gacgucggcu ccgacuggcg cuuccuccgc ggcuaccacc aguacgccua cgacggcaag      360

gacuacaucg cccucaagga ggaccuccgc uccuggaccg ccgccgacau ggccgcccag      420

accaccaagc acaaguggga ggccgcccac gucgccgagc agcuccgcgc cuaccucgag      480

ggcaccugcg ucgaguggcu ccgccgcuac cucgagaacg gcaaggagac ccuccagcgc      540

acc                                                                    543


<210>  1907
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1907
agccacucca ugagauacuu cuuuaccucu gugucaaggc ccggccgcgg ggagccucgg       60

uucaucgccg ucggauaugu ugacgauaca caguuugugc gauucgacag ugaugcugca      120

agccaacgua uggaaccaag agccccgugg auugagcagg aaggucccga guacugggac      180

ggcgaaacua ggaagguaaa agcgcauucc cagacgcacc ggguggaucu ggggacccuc      240

cgcggauauu acaaccaguc ugaggcuggc ucgcauacag uccaaagaau guaugguugc      300

gacguggggu cagauuggag guuucuucgg ggauaccacc aguaugccua cgacggcaag      360

gauuacauag cacugaaaga ggacuugcgc agcuggacug ccgcugauau ggcagcccag      420

accacaaagc auaaauggga agcugcccac guugcggagc aguuacgagc auaucuggaa      480

ggcaccugug uggaguggcu aagaagguac cucgagaaug ggaaggaaac ucugcaacgg      540

aca                                                                    543


<210>  1908
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1908
agccacagca ugagauacuu cuucaccagc gugagcagac ccggcagagg cgagcccaga       60

uucaucgccg ugggcuacgu ggacgacacc caguucguga gauucgacag cgacgccgcc      120

agccagagaa uggagcccag agcccccugg aucgagcagg agggccccga guacugggac      180

ggcgagacca gaaaggugaa ggcccacagc cagacccaca gaguggaccu gggcacccug      240

agaggcuacu acaaccagag cgaggccggc agccacaccg ugcagagaau guacggcugc      300

gacgugggca gcgacuggag auuccugaga ggcuaccacc aguacgccua cgacggcaag      360

gacuacaucg cccugaagga ggaccugaga agcuggaccg ccgccgacau ggccgcccag      420

accaccaagc acaaguggga ggccgcccac guggccgagc agcugagagc cuaccuggag      480

ggcaccugcg uggaguggcu gagaagauac cuggagaacg gcaaggagac ccugcagaga      540

acc                                                                    543


<210>  1909
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HLA-A2/m__Homo_sapiens__AH009136.2

<400>  1909
agccacucca ugagauacuu cuuuaccucu gugagccggc ccggccgcgg ggagccuaga       60

uucaucgccg ucggauaugu ugacgauaca caguuugugc gguucgacuc cgaugcugcc      120

ucucaacgca uggaaccgag agcgcccugg auugagcagg aaggcccuga guacugggac      180

ggggaaacgc ggaaggugaa agcucauagc cagacccacc gcgucgaucu gggaacacuc      240

agaggcuauu acaaccaguc cgaggccggg ucucauaccg ugcaacggau guauggaugc      300

gacguuggca gcgauuggcg cuuucugaga ggcuaccacc aguaugccua cgacgggaag      360

gauuacaucg cucuuaaaga ggaccugcgg uccuggacag ccgcugauau ggccgcgcag      420

accacaaagc auaaauggga agccgcucac guggccgagc agcuccgcgc uuaucuggaa      480

ggaaccugug ucgaguggcu uagacgguac cuggagaaug gcaaggaaac gcuccaacgc      540

acc                                                                    543


<210>  1910
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  homeobox_NKX3.1__Homo_sapiens__Q99801

<400>  1910

Met Leu Arg Val Pro Glu Pro Arg Pro Gly Glu Ala Lys Ala Glu Gly 
1               5                   10                  15      


Ala Ala Pro Pro Thr Pro Ser Lys Pro Leu Thr Ser Phe Leu Ile Gln 
            20                  25                  30          


Asp Ile Leu Arg Asp Gly Ala Gln Arg Gln Gly Gly Arg Thr Ser Ser 
        35                  40                  45              


Gln Arg Gln Arg Asp Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gly 
    50                  55                  60                  


Gly Arg Ser Arg Ala Gly Ala Gln Asn Asp Gln Leu Ser Thr Gly Pro 
65                  70                  75                  80  


Arg Ala Ala Pro Glu Glu Ala Glu Thr Leu Ala Glu Thr Glu Pro Glu 
                85                  90                  95      


Arg His Leu Gly Ser Tyr Leu Leu Asp Ser Glu Asn Thr Ser Gly Ala 
            100                 105                 110         


Leu Pro Arg Leu Pro Gln Thr Pro Lys Gln Pro Gln Lys Arg Ser Arg 
        115                 120                 125             


Ala Ala Phe Ser His Thr Gln Val Ile Glu Leu Glu Arg Lys Phe Ser 
    130                 135                 140                 


His Gln Lys Tyr Leu Ser Ala Pro Glu Arg Ala His Leu Ala Lys Asn 
145                 150                 155                 160 


Leu Lys Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg 
                165                 170                 175     


Tyr Lys Thr Lys Arg Lys Gln Leu Ser Ser Glu Leu Gly Asp Leu Glu 
            180                 185                 190         


Lys His Ser Ser Leu Pro Ala Leu Lys Glu Glu Ala Phe Ser Arg Ala 
        195                 200                 205             


Ser Leu Val Ser Val Tyr Asn Ser Tyr Pro Tyr Tyr Pro Tyr Leu Tyr 
    210                 215                 220                 


Cys Val Gly Ser Trp Ser Pro Ala Phe Trp 
225                 230                 


<210>  1911
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1911
augcucaggg uuccggagcc gcggcccggg gaggcgaaag cggagggggc cgcgccgccg       60

accccgucca agccgcucac guccuuccuc auccaggaca uccugcggga cggcgcgcag      120

cggcaaggcg gccgcacgag cagccagaga cagcgcgacc cggagccgga gccagagcca      180

gagccagagg gaggacgcag ccgcgccggg gcgcagaacg accagcugag caccgggccc      240

cgcgccgcgc cggaggaggc cgagacgcug gcagagaccg agccagaaag gcacuugggg      300

ucuuaucugu uggacucuga aaacacuuca ggcgcccuuc caaggcuucc ccaaaccccu      360

aagcagccgc agaagcgcuc ccgagcugcc uucucccaca cucaggugau cgaguuggag      420

aggaaguuca gccaucagaa guaccuguca gccccugaac gggcccaccu ggccaagaac      480

cucaagcuca cggagaccca agugaagaua ugguuccaga acagacgcua uaagacuaag      540

cgaaagcagc ucuccucgga gcugggagac uuggagaagc acuccucuuu gccggcccug      600

aaagaggagg ccuucucccg ggccucccug gucuccgugu auaacagcua uccuuacuac      660

ccauaccugu acugcguggg cagcuggagc ccagcuuuuu gguaa                      705


<210>  1912
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1912
augcugcgcg ugcccgagcc gcggcccggc gaggccaagg ccgagggggc ggccccgccc       60

acccccagca agccccucac cuccuuccug auccaggaca uccugcgcga cggcgcccag      120

cggcagggcg ggcgcacgag cucccagcgg cagcgcgacc ccgagcccga gccggagccc      180

gagcccgagg gcgggcggag ccgcgccggc gcccagaacg accagcucuc caccgggccc      240

cgggcggccc cggaggaggc cgagacccug gccgagaccg agcccgagcg ccaccugggc      300

agcuaccucc uggacuccga gaacacgagc ggggcgcugc cccggcuccc ccagaccccg      360

aagcagcccc agaagcgcuc ccgggccgcc uucagccaca cccaggucau cgagcuggag      420

cgcaaguucu cccaccagaa guaccugagc gcccccgagc gggcccaccu cgcgaagaac      480

cugaagcuga ccgagaccca ggugaagauc ugguuccaga accgccggua caagacgaag      540

cgcaagcagc ucuccagcga gcugggcgac cuggagaagc acuccagccu ccccgcccug      600

aaggaggagg ccuucucccg ggccagccug guguccgucu acaacagcua cccguacuac      660

cccuaccucu acugcguggg gagcuggucc cccgccuucu gguga                      705


<210>  1913
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1913
augcuccgcg uccccgagcc ccgccccggc gaggccaagg ccgagggcgc cgcccccccc       60

acccccucca agccccucac cuccuuccuc auccaggaca uccuccgcga cggcgcccag      120

cgccagggcg gccgcaccuc cucccagcgc cagcgcgacc ccgagcccga gcccgagccc      180

gagcccgagg gcggccgcuc ccgcgccggc gcccagaacg accagcucuc caccggcccc      240

cgcgccgccc ccgaggaggc cgagacccuc gccgagaccg agcccgagcg ccaccucggc      300

uccuaccucc ucgacuccga gaacaccucc ggcgcccucc cccgccuccc ccagaccccc      360

aagcagcccc agaagcgcuc ccgcgccgcc uucucccaca cccaggucau cgagcucgag      420

cgcaaguucu cccaccagaa guaccucucc gcccccgagc gcgcccaccu cgccaagaac      480

cucaagcuca ccgagaccca ggucaagauc ugguuccaga accgccgcua caagaccaag      540

cgcaagcagc ucuccuccga gcucggcgac cucgagaagc acuccucccu ccccgcccuc      600

aaggaggagg ccuucucccg cgccucccuc gucuccgucu acaacuccua ccccuacuac      660

cccuaccucu acugcgucgg cuccuggucc cccgccuucu gguga                      705


<210>  1914
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1914
augcugagag ugcccgagcc uaggccaggc gaagccaagg cugagggggc agccccgccc       60

accccuagca aaccacucac auccuuccuu auccaggaca uucugcggga uggagcgcaa      120

cgccagggug gccgaacuuc uucacagcgu cagagagacc ccgaaccuga gccagaaccc      180

gagccugaag ggggaaggag ucgggcuggc gcccaaaacg aucaguugag cacgggucca      240

cgcgcagccc cggaggaggc ugaaaccuua gcagagacag agcccgaaag acaccugggg      300

uccuaccuac ucgacucuga gaauacuucg ggagcccugc cuaggcuucc acagaccccc      360

aagcagccuc aaaaacgguc acgcgcugcc uuuagccaua cacaggucau agaacuggag      420

cgaaaguuca gucaccagaa auauuugucc gcgccagaaa gagcacaucu cgccaagaac      480

cugaagcuga ccgagacuca gguuaaaauc ugguuucaaa auaggcggua caagacaaaa      540

cguaagcagc ucucuagcga guuaggcgau cuggaaaaac acuccucacu ucccgcuuug      600

aaggaggaag ccuucagucg cgcaagccug gugucuguau auaacuccua cccguauuac      660

ccuuaucuau acugcguggg cucauggagc cccgcuuuuu gguga                      705


<210>  1915
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1915
augcugagag ugcccgagcc cagacccggc gaggccaagg ccgagggcgc cgcccccccc       60

acccccagca agccccugac cagcuuccug auccaggaca uccugagaga cggcgcccag      120

agacagggcg gcagaaccag cagccagaga cagagagacc ccgagcccga gcccgagccc      180

gagcccgagg gcggcagaag cagagccggc gcccagaacg accagcugag caccggcccc      240

agagccgccc ccgaggaggc cgagacccug gccgagaccg agcccgagag acaccugggc      300

agcuaccugc uggacagcga gaacaccagc ggcgcccugc ccagacugcc ccagaccccc      360

aagcagcccc agaagagaag cagagccgcc uucagccaca cccaggugau cgagcuggag      420

agaaaguuca gccaccagaa guaccugagc gcccccgaga gagcccaccu ggccaagaac      480

cugaagcuga ccgagaccca ggugaagauc ugguuccaga acagaagaua caagaccaag      540

agaaagcagc ugagcagcga gcugggcgac cuggagaagc acagcagccu gcccgcccug      600

aaggaggagg ccuucagcag agccagccug gugagcgugu acaacagcua ccccuacuac      660

cccuaccugu acugcguggg cagcuggagc cccgccuucu gguga                      705


<210>  1916
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       homeobox_NKX3.1__Homo_sapiens__AAG09781

<400>  1916
augcugagag ugcccgagcc ucggccgggc gaagccaagg cugagggggc cgcgcccccu       60

acccccagca aaccucucac auccuuccug auccaggaca uucuucgcga uggagcucaa      120

agacagggcg ggcggacguc uagccagcgc cagagagacc ccgaaccuga gccggaaccc      180

gagccugagg gaggccgguc ccgcgccggg gcccaaaacg aucagcuguc uaccggaccc      240

agagcugccc cugaagaggc ugaaacacuc gccgagaccg agcccgaacg gcaccugggc      300

agcuaccuuc uggacuccga gaauacaucu ggcgcgcucc cgcgccugcc ucagaccccc      360

aagcagccuc agaaaagaag ccgggccgcu uuuucccaua cacaagucau cgaacuggag      420

cgcaaguuca gccaccagaa auaucucucu gcccccgaaa gagcucaucu ggccaagaac      480

cuuaagcuga ccgagacgca gguuaaaauu ugguuucaaa aucggcgcua caagaccaaa      540

agaaagcagc ucuccagcga gcugggggau cuugaaaaac acucuucccu gcccgcgcuc      600

aaggaggaag ccuucagccg ggcuucucug guguccgugu auaacagcua cccuuauuac      660

ccguaucugu acugcgucgg auccuggucu cccgccuuuu gguga                      705


<210>  1917
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HOM-TES-85__Homo_sapiens__B2RBQ6

<400>  1917

Met Ala Ser Phe Arg Lys Leu Thr Leu Ser Glu Lys Val Pro Pro Asn 
1               5                   10                  15      


His Pro Ser Arg Lys Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp 
            20                  25                  30          


Ile Ile Ile Tyr Lys Glu Leu Glu Gly Thr Asn Ala Glu Glu Glu Lys 
        35                  40                  45              


Asn Lys Arg Gln Asn His Ser Lys Lys Glu Ser Pro Ser Arg Gln Gln 
    50                  55                  60                  


Ser Lys Ala His Arg His Arg His Arg Arg Asp Tyr Ser Arg Cys Arg 
65                  70                  75                  80  


Ser Asn Ser Glu Glu Gly Asn His Asp Lys Lys Pro Ser Gln Lys Pro 
                85                  90                  95      


Ser Gly Phe Lys Ser Gly Gln His Pro Leu Asn Gly Gln Pro Leu Ile 
            100                 105                 110         


Glu Gln Glu Lys Cys Ser Asp Asn Tyr Glu Ala Gln Ala Glu Lys Asn 
        115                 120                 125             


Gln Gly Gln Ser Glu Gly Asn Gln His Gln Ser Glu Gly Asn Pro Asp 
    130                 135                 140                 


Lys Ser Glu Glu Ser Gln Gly Gln Pro Glu Glu Asn His His Ser Glu 
145                 150                 155                 160 


Arg Ser Arg Asn His Leu Glu Arg Ser Leu Ser Gln Ser Asp Arg Ser 
                165                 170                 175     


Gln Gly Gln Leu Lys Arg His His Pro Gln Tyr Glu Arg Ser His Gly 
            180                 185                 190         


Gln Tyr Lys Arg Ser His Gly Gln Ser Glu Arg Ser His Gly His Ser 
        195                 200                 205             


Glu Arg Ser His Gly His Ser Glu Arg Ser His Gly His Ser Glu Arg 
    210                 215                 220                 


Ser His Gly His Ser Lys Arg Ser Arg Ser Gln Gly Asp Leu Val Asp 
225                 230                 235                 240 


Thr Gln Ser Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln 
                245                 250                 255     


Lys Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln Arg Asp 
            260                 265                 270         


Leu Ile Val Thr Gln Arg Asp Leu Val Ala Thr Glu Arg Asp Leu Ile 
        275                 280                 285             


Asn Gln Ser Gly Arg Ser His Gly Gln Ser Glu Arg His Gln Arg Tyr 
    290                 295                 300                 


Ser Thr Gly Lys Asn Thr Ile Thr Thr 
305                 310             


<210>  1918
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HOM-TES-85__Homo_sapiens__BAG37303

<400>  1918
auggcuucgu uucggaagcu aacgcuuucu gaaaaagugc cgccaaauca ucccagucgg       60

aaaaagguua acuuccuaga uaugucucua gacgacauua uaaucuauaa agaguuagaa      120

gggacaaaug cugaagaaga aaagaauaaa agacagaacc auaguaaaaa ggaaucgccu      180

ucaagacagc aaucaaaagc ucauagacau cgccaucgga gagacuacuc aagaugcaga      240

agcaacucug aggaaggaaa ucaugauaaa aaaccauccc aaaaaccuuc uggauucaag      300

ucuggacaac acccuuuaaa ugggcagccu uuaauugagc aggagaagug cagugacaau      360

uaugaggccc aagcagagaa gaaucaaggc cagucagagg ggaaccagca ucaaucagaa      420

ggaaauccgg acaaaucaga agaaucccag ggccaaccag aagaaaauca ucauucugag      480

cgaucccgaa accacuuaga gagaucucuu ucucagucag acagaucuca agggcagcua      540

aagagacauc auccccaaua ugagagaucu cauggccaau acaagagauc ucauggucag      600

ucugagagau cucauggcca cucagagaga ucucaugguc acucagagag aucucauggu      660

cacucagaga gaucucaugg ucacucaaag agaucucgua gccagggaga ucuuguggac      720

acucagagug aucucauagc cacucagaga gaucucauag ccacucagaa agaucucaua      780

gccacucaga gagaucucau agccacucag agagaucuca uagucacuca gagagaucuc      840

guggccacug agagagaucu cauaaaucag ucagggagau cucauggcca aucagaaaga      900

caucagagau acucaacagg uaaaaauaca auaacuacuu aa                         942


<210>  1919
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HOM-TES-85__Homo_sapiens__BAG37303

<400>  1919
auggccagcu uccgcaagcu gacccucucc gagaaggugc ccccgaacca ccccagccgg       60

aagaagguca acuuccugga caugucccug gacgacauca ucaucuacaa ggagcucgag      120

ggcaccaacg ccgaggagga gaagaacaag cgccagaacc acagcaagaa ggaguccccc      180

agccggcagc aguccaaggc gcaccgccac cggcaccgcc gggacuacag ccgcugccgg      240

uccaacagcg aggaggggaa ccacgacaag aagcccuccc agaagccgag cggcuucaag      300

uccgggcagc acccccugaa cggccagccc cugaucgagc aggagaagug cagcgacaac      360

uacgaggccc aggccgagaa gaaccagggg caguccgagg gcaaccagca ccagagcgag      420

ggcaaccccg acaaguccga ggagagccag gggcagccgg aggagaacca ccacuccgag      480

cgcagccgga accaccucga gcgcagccug ucccagagcg accgguccca gggccagcug      540

aagcgccacc acccccagua cgagcggagc cacgggcagu acaagcgcuc ccacggccag      600

agcgagcggu cccacgggca cagcgagcgc ucccacggcc acagcgagcg gucccacggc      660

cacagcgagc gcucccacgg gcacagcaag cggucccgca gccagggcga ccucguggac      720

acgcaguccg accugaucgc cacccagcgc gaccugaucg ccacccagaa ggaccucauc      780

gcgacccagc gggaccugau cgccacgcag cgcgaccuga ucgugaccca gcgggaccuc      840

gucgccaccg agcgcgaccu gaucaaccag agcgggcggu cccacggcca gagcgagcgc      900

caccagcggu acagcaccgg caagaacacg aucaccaccu ga                         942


<210>  1920
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HOM-TES-85__Homo_sapiens__BAG37303

<400>  1920
auggccuccu uccgcaagcu cacccucucc gagaaggucc cccccaacca ccccucccgc       60

aagaagguca acuuccucga caugucccuc gacgacauca ucaucuacaa ggagcucgag      120

ggcaccaacg ccgaggagga gaagaacaag cgccagaacc acuccaagaa ggaguccccc      180

ucccgccagc aguccaaggc ccaccgccac cgccaccgcc gcgacuacuc ccgcugccgc      240

uccaacuccg aggagggcaa ccacgacaag aagcccuccc agaagcccuc cggcuucaag      300

uccggccagc acccccucaa cggccagccc cucaucgagc aggagaagug cuccgacaac      360

uacgaggccc aggccgagaa gaaccagggc caguccgagg gcaaccagca ccaguccgag      420

ggcaaccccg acaaguccga ggagucccag ggccagcccg aggagaacca ccacuccgag      480

cgcucccgca accaccucga gcgcucccuc ucccaguccg accgcuccca gggccagcuc      540

aagcgccacc acccccagua cgagcgcucc cacggccagu acaagcgcuc ccacggccag      600

uccgagcgcu cccacggcca cuccgagcgc ucccacggcc acuccgagcg cucccacggc      660

cacuccgagc gcucccacgg ccacuccaag cgcucccgcu cccagggcga ccucgucgac      720

acccaguccg accucaucgc cacccagcgc gaccucaucg ccacccagaa ggaccucauc      780

gccacccagc gcgaccucau cgccacccag cgcgaccuca ucgucaccca gcgcgaccuc      840

gucgccaccg agcgcgaccu caucaaccag uccggccgcu cccacggcca guccgagcgc      900

caccagcgcu acuccaccgg caagaacacc aucaccaccu ga                         942


<210>  1921
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HOM-TES-85__Homo_sapiens__BAG37303

<400>  1921
auggccagcu ucagaaagcu gacccucucc gagaaagugc ccccuaacca cccaucuagg       60

aagaaaguca auuuucuuga caugucacug gaugacauca uuauauacaa ggaauuggag      120

ggcacaaacg cugaagagga gaaaaauaag cggcagaacc auaguaagaa agaaagcccg      180

ucccgccaac agucuaaggc acaccgacau cgucacagaa gggauuauuc gcggugccgc      240

ucaaauagcg aggaagggaa ccaugacaaa aagcccaguc agaaaccuuc cggauucaag      300

ucuggucagc acccauuaaa uggccaaccc cugaucgagc aggaaaagug uagcgauaac      360

uacgaggccc aggcggagaa aaaucagggg caauccgaag gaaaccagca ccagucagag      420

ggcaauccug acaagaguga agagagccag ggucaaccag aagagaacca ucacucugag      480

agauccagga aucaucuaga acggucacuc agccagagug aucgcucuca ggggcaacug      540

aaacgacacc acccccagua ugagagaucc cauggacagu acaagaggag ccacggccag      600

ucggaacggu cucauggcca cuccgagcgu ucacaugggc acagugaacg cagccacgga      660

cauuccgaga gaucucacgg ucauagcaaa aggucacgga gucaaggcga ccuuguugau      720

acucaguccg accugauugc uacgcagcga gauuugaucg ccacccagaa ggaccucauu      780

gcaacacaac gcgaucugau cgccacucag agagaccuga uagugaccca gagggaccuc      840

guagcuacag agcgggauuu aaucaaccag agcgggcgcu cucacggaca aucagaaaga      900

caccagaggu auaguaccgg caaaaauacu auuacaaccu ga                         942


<210>  1922
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HOM-TES-85__Homo_sapiens__BAG37303

<400>  1922
auggccagcu ucagaaagcu gacccugagc gagaaggugc cccccaacca ccccagcaga       60

aagaagguga acuuccugga caugagccug gacgacauca ucaucuacaa ggagcuggag      120

ggcaccaacg ccgaggagga gaagaacaag agacagaacc acagcaagaa ggagagcccc      180

agcagacagc agagcaaggc ccacagacac agacacagaa gagacuacag cagaugcaga      240

agcaacagcg aggagggcaa ccacgacaag aagcccagcc agaagcccag cggcuucaag      300

agcggccagc acccccugaa cggccagccc cugaucgagc aggagaagug cagcgacaac      360

uacgaggccc aggccgagaa gaaccagggc cagagcgagg gcaaccagca ccagagcgag      420

ggcaaccccg acaagagcga ggagagccag ggccagcccg aggagaacca ccacagcgag      480

agaagcagaa accaccugga gagaagccug agccagagcg acagaagcca gggccagcug      540

aagagacacc acccccagua cgagagaagc cacggccagu acaagagaag ccacggccag      600

agcgagagaa gccacggcca cagcgagaga agccacggcc acagcgagag aagccacggc      660

cacagcgaga gaagccacgg ccacagcaag agaagcagaa gccagggcga ccugguggac      720

acccagagcg accugaucgc cacccagaga gaccugaucg ccacccagaa ggaccugauc      780

gccacccaga gagaccugau cgccacccag agagaccuga ucgugaccca gagagaccug      840

guggccaccg agagagaccu gaucaaccag agcggcagaa gccacggcca gagcgagaga      900

caccagagau acagcaccgg caagaacacc aucaccaccu ga                         942


<210>  1923
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HOM-TES-85__Homo_sapiens__BAG37303

<400>  1923
auggccagcu ucagaaagcu gacccucucc gagaaagugc ccccuaacca cccgucucgg       60

aagaaaguca auuuucugga caugagccuu gaugacauca uuaucuacaa ggaacuggag      120

ggcacaaacg cugaagagga gaaaaauaag cgccagaacc auuccaagaa agaaucuccc      180

agcagacaac aguccaaggc ccaccggcau cgccacagac gggauuauuc ucgcugcaga      240

agcaauuccg aggaagggaa ccaugacaaa aagccuagcc agaaacccuc uggauucaag      300

uccggccagc acccucucaa ugggcaaccc cugauugagc aggaaaagug uagcgauaac      360

uacgaggcgc aggcugagaa aaaucaggga caaucugaag gcaaccagca ccaguccgag      420

gggaauccug acaagagcga agagucucag ggacaaccgg aagagaacca ucacuccgag      480

cggagccgca aucaucuuga aagaucccug ucucagagcg aucgguccca gggccaacuc      540

aaacgccacc acccccagua ugagagaagc cauggccagu acaagcgguc ucacgggcag      600

uccgaacgca gccauggaca cucugagaga agccauggcc acuccgaacg gucucacggg      660

cauagcgaga gaucccacgg acauagcaaa cgcucucggu cccaaggcga ccugguugau      720

acgcagagcg accugaucgc cacccagaga gaucucauug ccacacagaa ggaccugauc      780

gcuacccaac gcgaucuuau cgccacacag cgggaccuga uugugaccca gagagaccuc      840

guggcuacag agcgcgaucu gaucaaccag ucugggcggu cccacggaca aagcgaaaga      900

caccagcgcu auuccaccgg caaaaauacg auuaccacau ga                         942


<210>  1924
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HOM-TES-85__Homo_sapiens__Q9P127

<400>  1924

Met Ala Ser Phe Arg Lys Leu Thr Leu Ser Glu Lys Val Pro Pro Asn 
1               5                   10                  15      


His Pro Ser Arg Lys Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp 
            20                  25                  30          


Ile Ile Ile Tyr Lys Glu Leu Glu Gly Thr Asn Ala Glu Glu Glu Lys 
        35                  40                  45              


Asn Lys Arg Gln Asn His Ser Lys Lys Glu Ser Pro Ser Arg Gln Gln 
    50                  55                  60                  


Ser Lys Ala His Arg His Arg His Arg Arg Gly Tyr Ser Arg Cys Arg 
65                  70                  75                  80  


Ser Asn Ser Glu Glu Gly Asn His Asp Lys Lys Pro Ser Gln Lys Pro 
                85                  90                  95      


Ser Gly Phe Lys Ser Gly Gln His Pro Leu Asn Gly Gln Pro Leu Ile 
            100                 105                 110         


Glu Gln Glu Lys Cys Ser Asp Asn Tyr Glu Ala Gln Ala Glu Lys Asn 
        115                 120                 125             


Gln Gly Gln Ser Glu Gly Asn Gln His Gln Ser Glu Gly Asn Pro Asp 
    130                 135                 140                 


Lys Ser Glu Glu Ser Gln Gly Gln Pro Glu Glu Asn His His Ser Glu 
145                 150                 155                 160 


Arg Ser Arg Asn His Leu Glu Arg Ser Leu Ser Gln Ser Asp Arg Ser 
                165                 170                 175     


Gln Gly Gln Leu Lys Arg His His Pro Gln Tyr Glu Arg Ser His Gly 
            180                 185                 190         


Gln Tyr Lys Arg Ser His Gly Gln Ser Glu Arg Ser His Gly His Ser 
        195                 200                 205             


Glu Arg Ser His Gly His Ser Glu Arg Ser His Gly His Ser Glu Arg 
    210                 215                 220                 


Ser His Gly His Ser Lys Arg Ser Arg Ser Gln Gly Asp Leu Val Asp 
225                 230                 235                 240 


Thr Gln Ser Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln 
                245                 250                 255     


Lys Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln Arg Asp 
            260                 265                 270         


Leu Ile Val Thr Gln Arg Asp Leu Val Ala Thr Glu Arg Asp Leu Ile 
        275                 280                 285             


Asn Gln Ser Gly Arg Ser His Gly Gln Ser Glu Arg His Gln Arg Tyr 
    290                 295                 300                 


Ser Thr Gly Lys Asn Thr Ile Thr Thr 
305                 310             


<210>  1925
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HOM-TES-85__Homo_sapiens__AAI28135

<400>  1925
auggcuucgu uucggaagcu aacgcuuucu gaaaaagugc cgccaaauca ucccagucgg       60

aaaaagguua acuuccuaga uaugucucua gacgacauua uaaucuauaa agaguuagaa      120

gggacaaaug cugaagaaga aaagaauaaa agacagaacc auaguaaaaa ggaaucgccu      180

ucaagacagc aaucaaaagc ucauagacau cgccaucgga gaggcuacuc aagaugcaga      240

agcaacucug aggaaggaaa ucaugauaaa aaaccauccc aaaaaccuuc uggauucaag      300

ucuggacaac acccuuuaaa ugggcagccu uuaauugagc aggagaagug cagugacaau      360

uaugaggccc aagcagagaa gaaucaaggc cagucagagg ggaaccagca ucaaucagaa      420

ggaaauccgg acaaaucaga agaaucccag ggccaaccag aagaaaauca ucauucugag      480

cgaucccgaa accacuuaga gagaucucuu ucucagucag acagaucuca agggcagcua      540

aagagacauc auccccaaua ugagagaucu cauggccaau acaagagauc ucauggucaa      600

ucugagagau cucauggcca cucagagaga ucucaugguc acucagagag aucucauggu      660

cacucagaga gaucucaugg ucacucaaag agaucucgua gccagggaga ucuuguggac      720

acucagagug aucucauagc cacucagaga gaucucauag ccacucagaa agaucucaua      780

gccacucaga gagaucucau agccacucag agagaucuca uagucacuca gagagaucuc      840

guggccacug agagagaucu cauaaaucag ucagggagau cucauggcca aucagaaaga      900

caucagagau acucaacagg uaaaaauaca auaacuacuu aa                         942


<210>  1926
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HOM-TES-85__Homo_sapiens__AAI28135

<400>  1926
auggccagcu uccgcaagcu gacccucucc gagaaggugc ccccgaacca ccccagccgg       60

aagaagguca acuuccugga caugucccug gacgacauca ucaucuacaa ggagcucgag      120

ggcaccaacg ccgaggagga gaagaacaag cgccagaacc acagcaagaa ggaguccccc      180

agccggcagc aguccaaggc gcaccgccac cggcaccgcc ggggguacag ccgcugccgg      240

uccaacagcg aggagggcaa ccacgacaag aagcccuccc agaagccgag cggguucaag      300

uccggccagc acccccugaa cgggcagccc cugaucgagc aggagaagug cagcgacaac      360

uacgaggccc aggccgagaa gaaccagggc caguccgagg gcaaccagca ccagagcgag      420

gggaaccccg acaaguccga ggagagccag ggccagccgg aggagaacca ccacuccgag      480

cgcagccgga accaccucga gcgcagccug ucccagagcg accgguccca ggggcagcug      540

aagcgccacc acccccagua cgagcggagc cacggccagu acaagcgcuc ccacgggcag      600

agcgagcggu cccacggcca cagcgagcgc ucccacggcc acagcgagcg gucccacggg      660

cacagcgagc gcucccacgg ccacagcaag cggucccgca gccaggggga ccucguggac      720

acgcaguccg accugaucgc cacccagcgc gaccugaucg ccacccagaa ggaccucauc      780

gcgacccagc gggaccugau cgccacgcag cgcgaccuga ucgugaccca gcgggaccuc      840

gucgccaccg agcgcgaccu gaucaaccag agcggccggu cccacggcca gagcgagcgc      900

caccagcggu acagcaccgg gaagaacacg aucaccaccu ga                         942


<210>  1927
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HOM-TES-85__Homo_sapiens__AAI28135

<400>  1927
auggccuccu uccgcaagcu cacccucucc gagaaggucc cccccaacca ccccucccgc       60

aagaagguca acuuccucga caugucccuc gacgacauca ucaucuacaa ggagcucgag      120

ggcaccaacg ccgaggagga gaagaacaag cgccagaacc acuccaagaa ggaguccccc      180

ucccgccagc aguccaaggc ccaccgccac cgccaccgcc gcggcuacuc ccgcugccgc      240

uccaacuccg aggagggcaa ccacgacaag aagcccuccc agaagcccuc cggcuucaag      300

uccggccagc acccccucaa cggccagccc cucaucgagc aggagaagug cuccgacaac      360

uacgaggccc aggccgagaa gaaccagggc caguccgagg gcaaccagca ccaguccgag      420

ggcaaccccg acaaguccga ggagucccag ggccagcccg aggagaacca ccacuccgag      480

cgcucccgca accaccucga gcgcucccuc ucccaguccg accgcuccca gggccagcuc      540

aagcgccacc acccccagua cgagcgcucc cacggccagu acaagcgcuc ccacggccag      600

uccgagcgcu cccacggcca cuccgagcgc ucccacggcc acuccgagcg cucccacggc      660

cacuccgagc gcucccacgg ccacuccaag cgcucccgcu cccagggcga ccucgucgac      720

acccaguccg accucaucgc cacccagcgc gaccucaucg ccacccagaa ggaccucauc      780

gccacccagc gcgaccucau cgccacccag cgcgaccuca ucgucaccca gcgcgaccuc      840

gucgccaccg agcgcgaccu caucaaccag uccggccgcu cccacggcca guccgagcgc      900

caccagcgcu acuccaccgg caagaacacc aucaccaccu ga                         942


<210>  1928
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HOM-TES-85__Homo_sapiens__AAI28135

<400>  1928
auggccagcu ucagaaagcu gacccucucc gagaaagugc ccccuaacca cccaucuagg       60

aagaaaguca auuuucuuga caugucacug gaugacauca uuauauacaa ggaauuggag      120

ggcacaaacg cugaagagga gaaaaauaag cggcagaacc auaguaagaa agaaagcccg      180

ucccgccaac agucuaaggc acaccgacau cgucacagaa ggggguauuc gcggugccgc      240

ucaaauagcg aggaaggaaa ccaugauaaa aagcccaguc agaaaccuuc cgguuucaag      300

ucuggccagc acccauuaaa ugggcaaccc cugaucgagc aggaaaagug uagcgacaac      360

uacgaggccc aggcggagaa aaaucaggga caauccgaag gcaaccagca ccagucagag      420

gguaauccug auaagaguga agagagccag gggcaaccag aagagaacca ucacucugag      480

agauccagga aucaucuaga acggucacuc agccagagug accgcucuca gggacaacug      540

aaacgacacc acccccagua ugagagaucc cauggccagu acaagaggag ccacggccag      600

ucggaacggu cucaugggca cuccgagcgu ucacauggac acagugaacg cagccacggu      660

cauuccgaga gaucucacgg ccauagcaaa aggucacgga gucaagggga ucuuguugac      720

acucaguccg aucugauugc uacgcagcga gacuugaucg ccacccagaa ggaucucauu      780

gcaacacaac gcgaccugau cgccacucag agagaucuga uagugaccca gagggaccuc      840

guagcuacag agcgggacuu aaucaaccag agcggacgcu cucacggcca aucagaaaga      900

caccagaggu auaguaccgg uaaaaauacu auuacaaccu ga                         942


<210>  1929
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HOM-TES-85__Homo_sapiens__AAI28135

<400>  1929
auggccagcu ucagaaagcu gacccugagc gagaaggugc cccccaacca ccccagcaga       60

aagaagguga acuuccugga caugagccug gacgacauca ucaucuacaa ggagcuggag      120

ggcaccaacg ccgaggagga gaagaacaag agacagaacc acagcaagaa ggagagcccc      180

agcagacagc agagcaaggc ccacagacac agacacagaa gaggcuacag cagaugcaga      240

agcaacagcg aggagggcaa ccacgacaag aagcccagcc agaagcccag cggcuucaag      300

agcggccagc acccccugaa cggccagccc cugaucgagc aggagaagug cagcgacaac      360

uacgaggccc aggccgagaa gaaccagggc cagagcgagg gcaaccagca ccagagcgag      420

ggcaaccccg acaagagcga ggagagccag ggccagcccg aggagaacca ccacagcgag      480

agaagcagaa accaccugga gagaagccug agccagagcg acagaagcca gggccagcug      540

aagagacacc acccccagua cgagagaagc cacggccagu acaagagaag ccacggccag      600

agcgagagaa gccacggcca cagcgagaga agccacggcc acagcgagag aagccacggc      660

cacagcgaga gaagccacgg ccacagcaag agaagcagaa gccagggcga ccugguggac      720

acccagagcg accugaucgc cacccagaga gaccugaucg ccacccagaa ggaccugauc      780

gccacccaga gagaccugau cgccacccag agagaccuga ucgugaccca gagagaccug      840

guggccaccg agagagaccu gaucaaccag agcggcagaa gccacggcca gagcgagaga      900

caccagagau acagcaccgg caagaacacc aucaccaccu ga                         942


<210>  1930
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HOM-TES-85__Homo_sapiens__AAI28135

<400>  1930
auggccagcu ucagaaagcu gacccucucc gagaaagugc ccccuaacca cccgucucgg       60

aagaaaguca auuuucugga caugagccuu gaugacauca uuaucuacaa ggaacuggag      120

ggcacaaacg cugaagagga gaaaaauaag cgccagaacc auuccaagaa agaaucuccc      180

agcagacaac aguccaaggc ccaccggcau cgccacagac ggggguauuc ucgcugcaga      240

agcaauuccg aggaaggaaa ccaugauaaa aagccuagcc agaaacccuc uggcuucaag      300

uccgggcagc acccucucaa uggacaaccc cugauugagc aggaaaagug uagcgacaac      360

uacgaggcgc aggcugagaa aaaucagggc caaucugaag ggaaccagca ccaguccgag      420

ggaaauccug auaagagcga agagucucag ggccaaccgg aagagaacca ucacuccgag      480

cggagccgca aucaucuuga aagaucccug ucucagagcg accgguccca gggccaacuc      540

aaacgccacc acccccagua ugagagaagc caugggcagu acaagcgguc ucacggacag      600

uccgaacgca gccauggcca cucugagaga agccaugggc acuccgaacg gucucacgga      660

cauagcgaga gaucccacgg ccauagcaaa cgcucucggu cccaagggga ucugguugac      720

acgcagagcg aucugaucgc cacccagaga gaccucauug ccacacagaa ggaucugauc      780

gcuacccaac gcgaccuuau cgccacacag cgggaucuga uugugaccca gagagaccuc      840

guggcuacag agcgcgaccu gaucaaccag ucuggacggu cccacggcca aagcgaaaga      900

caccagcgcu auuccaccgg caaaaauacg auuaccacau ga                         942


<210>  1931
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HPG1__Homo_sapiens__12543784

<400>  1931

Met Ile Lys Lys Asn Leu Lys Lys Leu Gly Ile Glu Glu Thr Tyr Leu 
1               5                   10                  15      


Asn Ile Ile Lys Ala Ile Tyr Asp Arg Pro Thr Ala Ser Ile Gln Lys 
            20                  25                  30          


Thr Glu Asn Leu Ser Thr Lys Thr Gly Thr Ser Gln Glu Tyr His Leu 
        35                  40                  45              


Ser Pro Leu Trp Phe Tyr Ile Val Leu Glu Ile Leu Ala Ser Thr Ile 
    50                  55                  60                  


Arg Gln Glu Lys Asn Leu Lys Asp Ile His Thr Glu Lys Glu Glu Val 
65                  70                  75                  80  


Lys Leu Ser Leu Phe Ala Asp Ala Met Ile Leu Tyr Leu Lys Lys Pro 
                85                  90                  95      


Asn Asp Ser Thr Arg Lys Leu Leu Glu Leu Ile Lys Lys Ile His Ser 
            100                 105                 110         


Ser Cys Arg Ile Lys Ile Asn Ile His Phe Ala Phe Cys Ser Gln 
        115                 120                 125         


<210>  1932
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HPG1__Homo_sapiens__12543784

<400>  1932
augauaaaaa aaaaucuuaa aaaacugggu auagaagaaa cauaccuuaa cauaauaaaa       60

gccauauaug acagacccac agcuaguaua caaaaaacug aaaaccuuuc cacuaaaacu      120

ggaacaagcc aagaauacca ccugucacca cugugguucu acauaguacu ggaaauccua      180

gcuagcacaa ucagacaaga gaaaaauuua aaggacaucc acacugaaaa agaagaaguc      240

aaauuauccu uguuugcuga ugcuaugauc uuauauuuga aaaaaccuaa ugacuccaca      300

agaaaauuau uagaacugau aaaaaaaauu cauucaaguu gcaggauaaa aaucaauaua      360

cauuuugcau uuuguucaca auga                                             384


<210>  1933
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HPG1__Homo_sapiens__12543784

<400>  1933
augaucaaga agaaccugaa gaagcucggc aucgaggaga ccuaccugaa caucaucaag       60

gccaucuacg accgccccac cgccagcauc cagaagacgg agaaccuguc caccaagacc      120

gggaccagcc aggaguacca ccucuccccg cugugguucu acaucgugcu ggagauccuc      180

gcgagcacga uccggcagga gaagaaccug aaggacaucc acaccgagaa ggaggagguc      240

aagcuguccc ucuucgccga cgccaugauc cuguaccuga agaagcccaa cgacagcacc      300

cgcaagcucc uggagcugau caagaagauc cacuccagcu gccggaucaa gaucaacauc      360

cacuucgccu ucugcuccca guga                                             384


<210>  1934
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HPG1__Homo_sapiens__12543784

<400>  1934
augaucaaga agaaccucaa gaagcucggc aucgaggaga ccuaccucaa caucaucaag       60

gccaucuacg accgccccac cgccuccauc cagaagaccg agaaccucuc caccaagacc      120

ggcaccuccc aggaguacca ccucuccccc cucugguucu acaucguccu cgagauccuc      180

gccuccacca uccgccagga gaagaaccuc aaggacaucc acaccgagaa ggaggagguc      240

aagcucuccc ucuucgccga cgccaugauc cucuaccuca agaagcccaa cgacuccacc      300

cgcaagcucc ucgagcucau caagaagauc cacuccuccu gccgcaucaa gaucaacauc      360

cacuucgccu ucugcuccca guga                                             384


<210>  1935
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HPG1__Homo_sapiens__12543784

<400>  1935
augaucaaga aaaaccugaa gaaacucggc auugaggaaa ccuaccuuaa uauaaucaag       60

gccauuuaug acagacccac agcuagcauc cagaaaacug agaaccuguc cacgaagacc      120

gggacaucuc aagaauacca cuugucaccu uuaugguucu auauugugcu ggagauccua      180

gcaaguacua uaaggcagga aaagaaucuc aaagauaucc auaccgagaa ggaggaaguc      240

aaacugagcc uuuuugccga cgcgaugauu cuguacuuga agaaaccaaa cgauuccaca      300

cggaagcucc uggagcugau caagaaaauu cacucuucgu gccgcaucaa gauaaauauu      360

cauuucgcuu uuuguucaca guga                                             384


<210>  1936
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HPG1__Homo_sapiens__12543784

<400>  1936
augaucaaga agaaccugaa gaagcugggc aucgaggaga ccuaccugaa caucaucaag       60

gccaucuacg acagacccac cgccagcauc cagaagaccg agaaccugag caccaagacc      120

ggcaccagcc aggaguacca ccugagcccc cugugguucu acaucgugcu ggagauccug      180

gccagcacca ucagacagga gaagaaccug aaggacaucc acaccgagaa ggaggaggug      240

aagcugagcc uguucgccga cgccaugauc cuguaccuga agaagcccaa cgacagcacc      300

agaaagcugc uggagcugau caagaagauc cacagcagcu gcagaaucaa gaucaacauc      360

cacuucgccu ucugcagcca guga                                             384


<210>  1937
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HPG1__Homo_sapiens__12543784

<400>  1937
augaucaaga aaaaccugaa gaaacucggc auugaggaaa ccuaccugaa uaucauuaag       60

gccaucuaug acagacccac agcuagcauu cagaaaacgg agaaccuuuc caccaagaca      120

gggaccucuc aagaauacca ccugagcccu cucugguucu auaucgugcu ggagauccuu      180

gccuccacaa uucggcagga aaagaaucug aaagauaucc auaccgagaa ggaggaaguc      240

aaacucucuc uguuugcgga cgcuaugauu cuguaccuca agaaaccgaa cgauagcaca      300

cgcaagcugc uugagcugau caagaaaauu cacuccucuu gcagaaucaa gauuaauauc      360

cauuucgccu uuuguagcca guga                                             384


<210>  1938
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HS71A__Homo_sapiens__P0DMV8

<400>  1938

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  1939
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HS71A__Homo_sapiens__AAA63226

<400>  1939
auggccaaag ccgcggcgau cggcaucgac cugggcacca ccuacuccug cgugggggug       60

uuccaacacg gcaaggugga gaucaucgcc aacgaccagg gcaaccgcac cacccccagc      120

uacguggccu ucacggacac cgagcggcuc aucggggaug cggccaagaa ccagguggcg      180

cugaacccgc agaacaccgu guuugacgcg aagcgccuga uuggccgcaa guucggcgac      240

ccgguggugc agucggacau gaagcacugg ccuuuccagg ugaucaacga cggagacaag      300

cccaaggugc aggugagcua caagggggag accaaggcau ucuaccccga ggagaucucg      360

uccauggugc ugaccaagau gaaggagauc gccgaggcgu accugggcua cccggugacc      420

aacgcgguga ucaccgugcc ggccuacuuc aacgacucgc agcgccaggc caccaaggau      480

gcggguguga ucgcggggcu caacgugcug cggaucauca acgagcccac ggccgccgcc      540

aucgccuacg gccuggacag aacgggcaag ggggagcgca acgugcucau cuuugaccug      600

ggcgggggca ccuucgacgu guccauccug acgaucgacg acggcaucuu cgaggugaag      660

gccacggccg gggacaccca ccuggguggg gaggacuuug acaacaggcu ggugaaccac      720

uucguggagg aguucaagag aaaacacaag aaggacauca gccagaacaa gcgagccgug      780

aggcggcugc gcaccgccug cgagagggcc aagaggaccc ugucguccag cacccaggcc      840

agccuggaga ucgacucccu guuugagggc aucgacuucu acacguccau caccagggcg      900

agguucgagg agcugugcuc cgaccuguuc cgaagcaccc uggagcccgu ggagaaggcu      960

cugcgcgacg ccaagcugga caaggcccag auucacgacc ugguccuggu cgggggcucc     1020

acccgcaucc ccaaggugca gaagcugcug caggacuucu ucaacgggcg cgaccugaac     1080

aagagcauca accccgacga ggcuguggcc uacggggcgg cggugcaggc ggccauccug     1140

augggggaca aguccgagaa cgugcaggac cugcugcugc uggacguggc uccccugucg     1200

cuggggcugg agacggccgg aggcgugaug acugcccuga ucaagcgcaa cuccaccauc     1260

cccaccaagc agacgcagau cuucaccacc uacuccgaca accaacccgg ggugcugauc     1320

cagguguacg agggcgagag ggccaugacg aaagacaaca aucuguuggg gcgcuucgag     1380

cugagcggca ucccuccggc ccccaggggc gugccccaga ucgaggugac cuucgacauc     1440

gaugccaacg gcauccugaa cgucacggcc acggacaaga gcaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggccgccug agcaaggagg agaucgagcg cauggugcag     1560

gaggcggaga aguacaaagc ggaggacgag gugcagcgcg agaggguguc agccaagaac     1620

gcccuggagu ccuacgccuu caacaugaag agcgccgugg aggaugaggg gcucaagggc     1680

aagaucagcg aggccgacaa gaagaaggug cuggacaagu gucaagaggu caucucgugg     1740

cuggacgcca acaccuuggc cgagaaggac gaguuugagc acaagaggaa ggagcuggag     1800

caggugugua accccaucau cagcggacug uaccagggug ccgguggucc cgggccuggg     1860

ggcuucgggg cucagggucc caagggaggg ucugggucag gccccaccau ugaggaggua     1920

gauuag                                                                1926


<210>  1940
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HS71A__Homo_sapiens__AAA63226

<400>  1940
auggccaagg ccgcggccau cggcaucgac cuggggacca ccuacagcug cgugggcgug       60

uuccagcacg ggaaggugga gaucaucgcc aacgaccagg gcaaccgcac gacccccucc      120

uacguggccu ucaccgacac cgagcggcuc aucggggacg ccgcgaagaa ccaggucgcc      180

cugaacccgc agaacacggu guucgacgcc aagcgccuga ucggccggaa guucggcgac      240

cccguggucc agagcgacau gaagcacugg cccuuccagg ugaucaacga cggggacaag      300

cccaaggugc aggucuccua caagggcgag accaaggccu ucuacccgga ggagaucagc      360

uccauggugc ucaccaagau gaaggagauc gcggaggccu accuggggua ccccgugacc      420

aacgccguca ucacggugcc cgccuacuuc aacgacagcc agcgccaggc caccaaggac      480

gcgggcguga ucgccgggcu gaacguccuc cggaucauca acgagcccac cgccgccgcc      540

aucgcguacg gccuggaccg caccggcaag ggggagcgga acgugcugau cuucgaccuc      600

ggcgggggca cguucgacgu guccauccug accaucgacg acggcaucuu cgaggucaag      660

gccaccgccg gggacaccca ccugggcggg gaggacuucg acaaccgccu cgugaaccac      720

uucguggagg aguucaagcg gaagcacaag aaggacauca gccagaacaa gcgcgccguc      780

cggcgccugc ggacggccug cgagcgcgcg aagcggaccc uguccagcuc cacccaggcc      840

agccucgaga ucgacucccu guucgagggc aucgacuucu acaccagcau cacgcgcgcc      900

cgguucgagg agcugugcuc cgaccucuuc cgcagcaccc uggagccggu ggagaaggcc      960

cugcgggacg ccaagcucga caaggcgcag auccacgacc uggugcuggu cgggggcucc     1020

acccgcaucc ccaaggugca gaagcuccug caggacuucu ucaacggccg ggaccugaac     1080

aagagcauca accccgacga ggccgucgcc uacggggccg cggugcaggc cgccauccuc     1140

augggcgaca aguccgagaa cgugcaggac cugcugcucc uggacgucgc gccccugagc     1200

cucgggcugg agaccgccgg cggggugaug acggcccuga ucaagcgcaa cagcaccauc     1260

ccgaccaagc agacccagau cuucacgacc uacuccgaca accagcccgg cgugcucauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accugcuggg gcgguucgag     1380

cucagcggca ucccgcccgc gccccgcggg gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgucacggcc accgacaagu ccaccgggaa ggccaacaag     1500

aucaccauca cgaacgacaa gggccggcug agcaaggagg agaucgagcg cauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag gugcagcggg agcgcgucuc cgccaagaac     1620

gcccucgaga gcuacgcguu caacaugaag uccgccgugg aggacgaggg ccugaagggg     1680

aagaucagcg aggccgacaa gaagaaggug cuggacaagu gccaggaggu caucuccugg     1740

cucgacgcca acacccuggc ggagaaggac gaguucgagc acaagcggaa ggagcuggag     1800

caggucugca accccaucau cagcggccuc uaccaggggg ccggcggccc cgggccgggc     1860

ggguucggcg cccaggggcc caagggcggc uccgggagcg gccccaccau cgaggaggug     1920

gacuga                                                                1926


<210>  1941
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HS71A__Homo_sapiens__AAA63226

<400>  1941
auggccaagg ccgccgccau cggcaucgac cucggcacca ccuacuccug cgucggcguc       60

uuccagcacg gcaaggucga gaucaucgcc aacgaccagg gcaaccgcac cacccccucc      120

uacgucgccu ucaccgacac cgagcgccuc aucggcgacg ccgccaagaa ccaggucgcc      180

cucaaccccc agaacaccgu cuucgacgcc aagcgccuca ucggccgcaa guucggcgac      240

cccgucgucc aguccgacau gaagcacugg cccuuccagg ucaucaacga cggcgacaag      300

cccaaggucc aggucuccua caagggcgag accaaggccu ucuaccccga ggagaucucc      360

uccauggucc ucaccaagau gaaggagauc gccgaggccu accucggcua ccccgucacc      420

aacgccguca ucaccguccc cgccuacuuc aacgacuccc agcgccaggc caccaaggac      480

gccggcguca ucgccggccu caacguccuc cgcaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccucgaccg caccggcaag ggcgagcgca acguccucau cuucgaccuc      600

ggcggcggca ccuucgacgu cuccauccuc accaucgacg acggcaucuu cgaggucaag      660

gccaccgccg gcgacaccca ccucggcggc gaggacuucg acaaccgccu cgucaaccac      720

uucgucgagg aguucaagcg caagcacaag aaggacaucu cccagaacaa gcgcgccguc      780

cgccgccucc gcaccgccug cgagcgcgcc aagcgcaccc ucuccuccuc cacccaggcc      840

ucccucgaga ucgacucccu cuucgagggc aucgacuucu acaccuccau cacccgcgcc      900

cgcuucgagg agcucugcuc cgaccucuuc cgcuccaccc ucgagcccgu cgagaaggcc      960

cuccgcgacg ccaagcucga caaggcccag auccacgacc ucguccucgu cggcggcucc     1020

acccgcaucc ccaaggucca gaagcuccuc caggacuucu ucaacggccg cgaccucaac     1080

aaguccauca accccgacga ggccgucgcc uacggcgccg ccguccaggc cgccauccuc     1140

augggcgaca aguccgagaa cguccaggac cuccuccucc ucgacgucgc cccccucucc     1200

cucggccucg agaccgccgg cggcgucaug accgcccuca ucaagcgcaa cuccaccauc     1260

cccaccaagc agacccagau cuucaccacc uacuccgaca accagcccgg cguccucauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accuccucgg ccgcuucgag     1380

cucuccggca ucccccccgc cccccgcggc gucccccaga ucgaggucac cuucgacauc     1440

gacgccaacg gcauccucaa cgucaccgcc accgacaagu ccaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggccgccuc uccaaggagg agaucgagcg caugguccag     1560

gaggccgaga aguacaaggc cgaggacgag guccagcgcg agcgcgucuc cgccaagaac     1620

gcccucgagu ccuacgccuu caacaugaag uccgccgucg aggacgaggg ccucaagggc     1680

aagaucuccg aggccgacaa gaagaagguc cucgacaagu gccaggaggu caucuccugg     1740

cucgacgcca acacccucgc cgagaaggac gaguucgagc acaagcgcaa ggagcucgag     1800

caggucugca accccaucau cuccggccuc uaccagggcg ccggcggccc cggccccggc     1860

ggcuucggcg cccagggccc caagggcggc uccggcuccg gccccaccau cgaggagguc     1920

gacuga                                                                1926


<210>  1942
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HS71A__Homo_sapiens__AAA63226

<400>  1942
auggccaagg cugcagccau cggcauugac cuggggacca cauacagcug cgugggaguc       60

uuccagcacg guaaaguuga gauaaucgcg aacgaucaag gcaauagaac uacgcccucc      120

uauguggcuu uuaccgacac agaaaggcuc auuggggaug ccgcaaagaa ccagguagcc      180

cuuaauccuc agaacacugu guucgacgcu aaacggcuga ucggacgcaa guuuggcgau      240

ccagucgugc agucugacau gaaacauugg ccguuccaag uuauuaauga uggugacaag      300

cccaaggugc aggucucaua caaaggggag accaaggcau uuuauccuga agagaucagu      360

agcauggugu ugacaaaaau gaaggaaaua gccgaggcuu acuuaggaua uccaguaacc      420

aacgccguua ucacugugcc cgcguacuuc aaugauuccc agcgacaggc aacaaaagac      480

gccggcguca uugcuggccu gaacgugcua cguaucauua augagccuac cgccgcagcu      540

aucgccuaug ggcucgauag aacgggaaag ggugaaagga acgugcugau auuugaccuu      600

ggcgggggaa cuuucgaugu cucuauucug accaucgacg acggcauuuu ugagguuaag      660

gcgacagccg gugauacuca ccuuggggga gaagacuucg auaaucggcu cgugaaccau      720

uuuguagagg aguucaaacg caagcacaaa aaggacaucu cgcaaaauaa aagagcagug      780

aggcggcugc gcaccgcuug ugaacgagcc aagagaacac ugucaagcag uacccaggcu      840

ucccucgaga ucgauucuuu auuugaaggc auugacuucu acacgagcau aacuagggcc      900

cgguucgagg aacugugcuc cgaucuuuuu cguucaacau uggagccagu cgagaaagca      960

cugcgcgacg ccaagcuaga uaaggcucag auccaugacc ucgugcuggu uggcgggagu     1020

acccggauuc ccaaagugca gaaguugcug caagauuucu uuaacggaag ggacuugaau     1080

aaaagcauca acccugacga agcggucgca uacggugccg cugugcaggc cgcaauacuc     1140

augggcgaua agucugagaa cguacaggac cuguuacugc ucgauguugc cccacuuucc     1200

cugggguugg aaacugcugg aggcgugaug acagcccuaa uuaaaagaaa uucaaccauc     1260

ccgacgaagc aaacccagau cuucacaacu uauagcgaca accagcccgg uguccugauu     1320

cagguguacg agggggaacg agcaaugacc aaggauaaua accuccuggg ccgcuuugag     1380

cuuaguggaa ucccuccagc gcccagaggc gucccucaaa uugaggugac auucgacaua     1440

gaugcuaaug ggauccugaa cguuacugcc accgacaaau cuacaggaaa ggcaaauaaa     1500

auuaccauca cuaacgauaa ggguagguug uccaaagaag agaucgaacg gauggugcag     1560

gaggccgaaa aguauaaggc ugaggacgag guacagcgcg aaagagucag cgccaaaaau     1620

gcacucgagu cguacgcuuu uaacaugaag ucugccgugg aagaugaggg ccugaaaggg     1680

aagauuuccg aggcggacaa aaagaagguu uuagauaaau gucaggaagu gauaucaugg     1740

cuggacgcca auacgcuagc ugagaaggac gaguucgaac acaaaaggaa ggaacucgag     1800

caagucugca acccaaucau uaguggacug uaucagggcg ccggugggcc cggcccggga     1860

ggcuuugggg cacagggacc uaaagguggc agcggguccg gacccacaau cgaggaagug     1920

gauuga                                                                1926


<210>  1943
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HS71A__Homo_sapiens__AAA63226

<400>  1943
auggccaagg ccgccgccau cggcaucgac cugggcacca ccuacagcug cgugggcgug       60

uuccagcacg gcaaggugga gaucaucgcc aacgaccagg gcaacagaac cacccccagc      120

uacguggccu ucaccgacac cgagagacug aucggcgacg ccgccaagaa ccagguggcc      180

cugaaccccc agaacaccgu guucgacgcc aagagacuga ucggcagaaa guucggcgac      240

cccguggugc agagcgacau gaagcacugg cccuuccagg ugaucaacga cggcgacaag      300

cccaaggugc aggugagcua caagggcgag accaaggccu ucuaccccga ggagaucagc      360

agcauggugc ugaccaagau gaaggagauc gccgaggccu accugggcua ccccgugacc      420

aacgccguga ucaccgugcc cgccuacuuc aacgacagcc agagacaggc caccaaggac      480

gccggcguga ucgccggccu gaacgugcug agaaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccuggacag aaccggcaag ggcgagagaa acgugcugau cuucgaccug      600

ggcggcggca ccuucgacgu gagcauccug accaucgacg acggcaucuu cgaggugaag      660

gccaccgccg gcgacaccca ccugggcggc gaggacuucg acaacagacu ggugaaccac      720

uucguggagg aguucaagag aaagcacaag aaggacauca gccagaacaa gagagccgug      780

agaagacuga gaaccgccug cgagagagcc aagagaaccc ugagcagcag cacccaggcc      840

agccuggaga ucgacagccu guucgagggc aucgacuucu acaccagcau caccagagcc      900

agauucgagg agcugugcag cgaccuguuc agaagcaccc uggagcccgu ggagaaggcc      960

cugagagacg ccaagcugga caaggcccag auccacgacc uggugcuggu gggcggcagc     1020

accagaaucc ccaaggugca gaagcugcug caggacuucu ucaacggcag agaccugaac     1080

aagagcauca accccgacga ggccguggcc uacggcgccg ccgugcaggc cgccauccug     1140

augggcgaca agagcgagaa cgugcaggac cugcugcugc uggacguggc cccccugagc     1200

cugggccugg agaccgccgg cggcgugaug accgcccuga ucaagagaaa cagcaccauc     1260

cccaccaagc agacccagau cuucaccacc uacagcgaca accagcccgg cgugcugauc     1320

cagguguacg agggcgagag agccaugacc aaggacaaca accugcuggg cagauucgag     1380

cugagcggca ucccccccgc ccccagaggc gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgugaccgcc accgacaaga gcaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggcagacug agcaaggagg agaucgagag aauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag gugcagagag agagagugag cgccaagaac     1620

gcccuggaga gcuacgccuu caacaugaag agcgccgugg aggacgaggg ccugaagggc     1680

aagaucagcg aggccgacaa gaagaaggug cuggacaagu gccaggaggu gaucagcugg     1740

cuggacgcca acacccuggc cgagaaggac gaguucgagc acaagagaaa ggagcuggag     1800

caggugugca accccaucau cagcggccug uaccagggcg ccggcggccc cggccccggc     1860

ggcuucggcg cccagggccc caagggcggc agcggcagcg gccccaccau cgaggaggug     1920

gacuga                                                                1926


<210>  1944
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HS71A__Homo_sapiens__AAA63226

<400>  1944
auggccaagg cugccgcgau cggcauugac cuggggacca cauacagcug cgugggaguc       60

uuccagcacg gcaaaguuga gaucauugcu aacgaucaag ggaauagaac gacccccucc      120

uauguggccu uuacagacac cgaacggcuc aucggagaug ccgcuaagaa ccagguggcc      180

cugaauccuc agaacacagu cuucgacgcu aaacgccuua uuggcagaaa guuuggggau      240

ccggugguuc agucugacau gaaacauugg cccuuccaag ugaucaauga uggagacaag      300

ccuaaggucc aggugagcua caaaggcgag accaaggccu uuuaucccga agagaucucc      360

ucuaugguuc ugacaaaaau gaaggaaauu gcggaggccu accucggcua uccugugacc      420

aacgcuguca ucacggugcc cgccuacuuc aaugauagcc agcggcaggc uaccaaagac      480

gccgggguga uugcgggacu gaacguccuu cgcaucauua augagccuac agccgcugcc      540

aucgcuuaug gccuggauag aaccgggaag ggagaacgga acguucucau uuuugaccug      600

ggcgggggaa cauucgaugu guccauccug accaucgacg acggcauuuu ugaggugaag      660

gccacggccg gcgauacaca ccucggggga gaagacuucg auaaucgccu ggucaaccau      720

uuuguggagg aguucaaaag aaagcacaaa aaggacaucu cucaaaauaa acgggcuguu      780

cgcagacuuc ggaccgcgug ugaacgcgcc aagagaacac ugagcuccag cacccaggcu      840

ucucucgaga uugauucccu guuugaaggc aucgacuucu acaccagcau uacacgggcc      900

cgcuucgagg aacuuugcuc ugaucuguuu agauccacgc ucgagccggu ggagaaagcc      960

cugcgggacg cuaagcugga uaaggcccag auccaugacc ucguccuggu ugggggaagc     1020

accagaaucc ccaaagugca gaaacuucug caagauuucu uuaacggccg cgaccucaau     1080

aagucuauua acccugacga agcgguggcu uacggggccg ccguccaggc ugccauccug     1140

augggagaua aguccgagaa cgugcaggac cuucugcucc uggaugucgc uccccugagc     1200

cucggccugg aaacagccgg cggggugaug accgcgcuua uuaaacggaa uagcacaauc     1260

ccuaccaagc aaacgcagau uuucacaacc uauucugaca accagcccgg aguucugauc     1320

cagguguacg agggcgaaag agccaugacc aaggauaaua accuccuggg gcgcuuugag     1380

cuuagcggaa ucccgccugc uccccggggc gucccucaaa uugaggugac auucgacauc     1440

gaugccaaug ggauucugaa cguuaccgcu acagacaaau ccacgggcaa ggccaauaaa     1500

aucaccauua caaacgauaa gggaagacuc agcaaagaag agaucgaacg cauggugcag     1560

gaggcggaaa aguauaaggc cgaggacgag guccagcggg aaagaguguc ugcuaaaaau     1620

gcccuggagu ccuacgcuuu uaacaugaag uccgccgugg aagaugaggg ccugaaaggg     1680

aagauuucug aggccgacaa aaagaagguu cucgauaaau gucaggaagu caucagcugg     1740

cuggacgcua auacccuugc ggagaaggac gaguucgaac acaaacgcaa ggaacuggag     1800

caagugugca accccaucau uuccggacuc uaucagggcg ccgggggacc cggcccuggg     1860

ggcuuuggag cucagggccc gaaaggggga ucuggcagcg ggcccacaau cgaggaagug     1920

gauuga                                                                1926


<210>  1945
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HS71B__Homo_sapiens__P0DMV9

<400>  1945

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  1946
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HS71B__Homo_sapiens__AAA63227

<400>  1946
auggccaaag ccgcggcgau cggcaucgac cugggcacca ccuacuccug cgugggggug       60

uuccaacacg gcaaggugga gaucaucgcc aacgaccagg gcaaccgcac cacccccagc      120

uacguggccu ucacggacac cgagcggcuc aucggggaug cggccaagaa ccagguggcg      180

cugaacccgc agaacaccgu guuugacgcg aagcgccuga ucggccgcaa guucggcgac      240

ccgguggugc agucggacau gaagcacugg ccuuuccagg ugaucaacga cggagacaag      300

cccaaggugc aggugagcua caagggggag accaaggcau ucuaccccga ggagaucucg      360

uccauggugc ugaccaagau gaaggagauc gccgaggcgu accugggcua cccggugacc      420

aacgcgguga ucaccgugcc ggccuacuuc aacgacucgc agcgccaggc caccaaggau      480

gcggguguga ucgcggggcu caacgugcug cggaucauca acgagcccac ggccgccgcc      540

aucgccuacg gccuggacag aacgggcaag ggggagcgca acguccugau cuuugaccug      600

ggcgggggca ccuucgacgu guccauccug acgaucgacg acggcaucuu cgaggugaag      660

gccacggccg gggacaccca ccuggguggg gaggacuuug acaacaggcu ggugaaccac      720

uucguggagg aguucaagag aaaacacaag aaggacauca gccagaacaa gcgagccgug      780

aggcggcugc gcaccgccug cgagagggcc aagaggaccc ugucguccag cacccaggcc      840

agccuggaga ucgacucccu guuugagggc aucgacuucu acacguccau caccagggcg      900

agguucgagg agcugugcuc cgaccuguuc cgaagcaccc uggagcccgu ggagaaggcu      960

cugcgcgacg ccaagcugga caaggcccag auucacgacc ugguccuggu cgggggcucc     1020

acccgcaucc ccaaggugca gaagcugcug caagacuucu ucaacgggcg cgaccugaac     1080

aagagcauca accccgacga ggcuguggcc uacggggcgg cggugcaggc ggccauccug     1140

augggggaca aguccgagaa cgugcaggac cugcugcugc uggacguggc uccccugucg     1200

cuggggcugg agacggccgg aggcgugaug acugcccuga ucaagcgcaa cuccaccauc     1260

cccaccaagc agacgcagau cuucaccacc uacuccgaca accaacccgg ggugcugauc     1320

cagguguacg agggcgagag ggccaugacg aaagacaaca aucuguuggg gcgcuucgag     1380

cugagcggca ucccuccggc ccccaggggc gugccccaga ucgaggugac cuucgacauc     1440

gaugccaacg gcauccugaa cgucacggcc acggacaaga gcaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggccgccug agcaaggagg agaucgagcg cauggugcag     1560

gaggcggaga aguacaaagc ggaggacgag gugcagcgcg agaggguguc agccaagaac     1620

gcccuggagu ccuacgccuu caacaugaag agcgccgugg aggaugaggg gcucaagggc     1680

aagaucagcg aggccgacaa gaagaagguu cuggacaagu gucaagaggu caucucgugg     1740

cuggacgcca acaccuuggc cgagaaggac gaguuugagc acaagaggaa ggagcuggag     1800

caggugugua accccaucau cagcggacug uaccagggug ccgguggucc cgggccuggc     1860

ggcuucgggg cucagggucc caagggaggg ucugggucag gcccuaccau ugaggaggug     1920

gauuag                                                                1926


<210>  1947
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HS71B__Homo_sapiens__AAA63227

<400>  1947
auggccaagg ccgcggccau cggcaucgac cuggggacca ccuacagcug cgugggcgug       60

uuccagcacg ggaaggugga gaucaucgcc aacgaccagg gcaaccgcac gacccccucc      120

uacguggccu ucaccgacac cgagcggcuc aucggggacg ccgcgaagaa ccaggucgcc      180

cugaacccgc agaacacggu guucgacgcc aagcgccuga ucggccggaa guucggcgac      240

cccguggucc agagcgacau gaagcacugg cccuuccagg ugaucaacga cggggacaag      300

cccaaggugc aggucuccua caagggcgag accaaggccu ucuacccgga ggagaucagc      360

uccauggugc ucaccaagau gaaggagauc gcggaggccu accuggggua ccccgugacc      420

aacgccguca ucacggugcc cgccuacuuc aacgacagcc agcgccaggc caccaaggac      480

gcgggcguga ucgccgggcu gaacguccuc cggaucauca acgagcccac cgccgccgcc      540

aucgcguacg gccuggaccg caccggcaag ggggagcgga acgugcugau cuucgaccuc      600

ggcgggggca cguucgacgu guccauccug accaucgacg acggcaucuu cgaggucaag      660

gccaccgccg gggacaccca ccugggcggg gaggacuucg acaaccgccu cgugaaccac      720

uucguggagg aguucaagcg gaagcacaag aaggacauca gccagaacaa gcgcgccguc      780

cggcgccugc ggacggccug cgagcgcgcg aagcggaccc uguccagcuc cacccaggcc      840

agccucgaga ucgacucccu guucgagggc aucgacuucu acaccagcau cacgcgcgcc      900

cgguucgagg agcugugcuc cgaccucuuc cgcagcaccc uggagccggu ggagaaggcc      960

cugcgggacg ccaagcucga caaggcgcag auccacgacc uggugcuggu cgggggcucc     1020

acccgcaucc ccaaggugca gaagcuccug caggacuucu ucaacggccg ggaccugaac     1080

aagagcauca accccgacga ggccgucgcc uacggggccg cggugcaggc cgccauccuc     1140

augggcgaca aguccgagaa cgugcaggac cugcugcucc uggacgucgc gccccugagc     1200

cucgggcugg agaccgccgg cggggugaug acggcccuga ucaagcgcaa cagcaccauc     1260

ccgaccaagc agacccagau cuucacgacc uacuccgaca accagcccgg cgugcucauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accugcuggg gcgguucgag     1380

cucagcggca ucccgcccgc gccccgcggg gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgucacggcc accgacaagu ccaccgggaa ggccaacaag     1500

aucaccauca cgaacgacaa gggccggcug agcaaggagg agaucgagcg cauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag gugcagcggg agcgcgucuc cgccaagaac     1620

gcccucgaga gcuacgcguu caacaugaag uccgccgugg aggacgaggg ccugaagggg     1680

aagaucagcg aggccgacaa gaagaaggug cuggacaagu gccaggaggu caucuccugg     1740

cucgacgcca acacccuggc ggagaaggac gaguucgagc acaagcggaa ggagcuggag     1800

caggucugca accccaucau cagcggccuc uaccaggggg ccggcggccc cgggccgggc     1860

ggguucggcg cccaggggcc caagggcggc uccgggagcg gccccaccau cgaggaggug     1920

gacuga                                                                1926


<210>  1948
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HS71B__Homo_sapiens__AAA63227

<400>  1948
auggccaagg ccgccgccau cggcaucgac cucggcacca ccuacuccug cgucggcguc       60

uuccagcacg gcaaggucga gaucaucgcc aacgaccagg gcaaccgcac cacccccucc      120

uacgucgccu ucaccgacac cgagcgccuc aucggcgacg ccgccaagaa ccaggucgcc      180

cucaaccccc agaacaccgu cuucgacgcc aagcgccuca ucggccgcaa guucggcgac      240

cccgucgucc aguccgacau gaagcacugg cccuuccagg ucaucaacga cggcgacaag      300

cccaaggucc aggucuccua caagggcgag accaaggccu ucuaccccga ggagaucucc      360

uccauggucc ucaccaagau gaaggagauc gccgaggccu accucggcua ccccgucacc      420

aacgccguca ucaccguccc cgccuacuuc aacgacuccc agcgccaggc caccaaggac      480

gccggcguca ucgccggccu caacguccuc cgcaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccucgaccg caccggcaag ggcgagcgca acguccucau cuucgaccuc      600

ggcggcggca ccuucgacgu cuccauccuc accaucgacg acggcaucuu cgaggucaag      660

gccaccgccg gcgacaccca ccucggcggc gaggacuucg acaaccgccu cgucaaccac      720

uucgucgagg aguucaagcg caagcacaag aaggacaucu cccagaacaa gcgcgccguc      780

cgccgccucc gcaccgccug cgagcgcgcc aagcgcaccc ucuccuccuc cacccaggcc      840

ucccucgaga ucgacucccu cuucgagggc aucgacuucu acaccuccau cacccgcgcc      900

cgcuucgagg agcucugcuc cgaccucuuc cgcuccaccc ucgagcccgu cgagaaggcc      960

cuccgcgacg ccaagcucga caaggcccag auccacgacc ucguccucgu cggcggcucc     1020

acccgcaucc ccaaggucca gaagcuccuc caggacuucu ucaacggccg cgaccucaac     1080

aaguccauca accccgacga ggccgucgcc uacggcgccg ccguccaggc cgccauccuc     1140

augggcgaca aguccgagaa cguccaggac cuccuccucc ucgacgucgc cccccucucc     1200

cucggccucg agaccgccgg cggcgucaug accgcccuca ucaagcgcaa cuccaccauc     1260

cccaccaagc agacccagau cuucaccacc uacuccgaca accagcccgg cguccucauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accuccucgg ccgcuucgag     1380

cucuccggca ucccccccgc cccccgcggc gucccccaga ucgaggucac cuucgacauc     1440

gacgccaacg gcauccucaa cgucaccgcc accgacaagu ccaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggccgccuc uccaaggagg agaucgagcg caugguccag     1560

gaggccgaga aguacaaggc cgaggacgag guccagcgcg agcgcgucuc cgccaagaac     1620

gcccucgagu ccuacgccuu caacaugaag uccgccgucg aggacgaggg ccucaagggc     1680

aagaucuccg aggccgacaa gaagaagguc cucgacaagu gccaggaggu caucuccugg     1740

cucgacgcca acacccucgc cgagaaggac gaguucgagc acaagcgcaa ggagcucgag     1800

caggucugca accccaucau cuccggccuc uaccagggcg ccggcggccc cggccccggc     1860

ggcuucggcg cccagggccc caagggcggc uccggcuccg gccccaccau cgaggagguc     1920

gacuga                                                                1926


<210>  1949
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HS71B__Homo_sapiens__AAA63227

<400>  1949
auggccaagg cugcagccau cggcauugac cuggggacca cauacagcug cgugggaguc       60

uuccagcacg guaaaguuga gauaaucgcg aacgaucaag gcaauagaac uacgcccucc      120

uauguggcuu uuaccgacac agaaaggcuc auuggggaug ccgcaaagaa ccagguagcc      180

cuuaauccuc agaacacugu guucgacgcu aaacggcuga ucggacgcaa guuuggcgau      240

ccagucgugc agucugacau gaaacauugg ccguuccaag uuauuaauga uggugacaag      300

cccaaggugc aggucucaua caaaggggag accaaggcau uuuauccuga agagaucagu      360

agcauggugu ugacaaaaau gaaggaaaua gccgaggcuu acuuaggaua uccaguaacc      420

aacgccguua ucacugugcc cgcguacuuc aaugauuccc agcgacaggc aacaaaagac      480

gccggcguca uugcuggccu gaacgugcua cguaucauua augagccuac cgccgcagcu      540

aucgccuaug ggcucgauag aacgggaaag ggugaaagga acgugcugau auuugaccuu      600

ggcgggggaa cuuucgaugu cucuauucug accaucgacg acggcauuuu ugagguuaag      660

gcgacagccg gugauacuca ccuuggggga gaagacuucg auaaucggcu cgugaaccau      720

uuuguagagg aguucaaacg caagcacaaa aaggacaucu cgcaaaauaa aagagcagug      780

aggcggcugc gcaccgcuug ugaacgagcc aagagaacac ugucaagcag uacccaggcu      840

ucccucgaga ucgauucuuu auuugaaggc auugacuucu acacgagcau aacuagggcc      900

cgguucgagg aacugugcuc cgaucuuuuu cguucaacau uggagccagu cgagaaagca      960

cugcgcgacg ccaagcuaga uaaggcucag auccaugacc ucgugcuggu uggcgggagu     1020

acccggauuc ccaaagugca gaaguugcug caagauuucu uuaacggaag ggacuugaau     1080

aaaagcauca acccugacga agcggucgca uacggugccg cugugcaggc cgcaauacuc     1140

augggcgaua agucugagaa cguacaggac cuguuacugc ucgauguugc cccacuuucc     1200

cugggguugg aaacugcugg aggcgugaug acagcccuaa uuaaaagaaa uucaaccauc     1260

ccgacgaagc aaacccagau cuucacaacu uauagcgaca accagcccgg uguccugauu     1320

cagguguacg agggggaacg agcaaugacc aaggauaaua accuccuggg ccgcuuugag     1380

cuuaguggaa ucccuccagc gcccagaggc gucccucaaa uugaggugac auucgacaua     1440

gaugcuaaug ggauccugaa cguuacugcc accgacaaau cuacaggaaa ggcaaauaaa     1500

auuaccauca cuaacgauaa ggguagguug uccaaagaag agaucgaacg gauggugcag     1560

gaggccgaaa aguauaaggc ugaggacgag guacagcgcg aaagagucag cgccaaaaau     1620

gcacucgagu cguacgcuuu uaacaugaag ucugccgugg aagaugaggg ccugaaaggg     1680

aagauuuccg aggcggacaa aaagaagguu uuagauaaau gucaggaagu gauaucaugg     1740

cuggacgcca auacgcuagc ugagaaggac gaguucgaac acaaaaggaa ggaacucgag     1800

caagucugca acccaaucau uaguggacug uaucagggcg ccggugggcc cggcccggga     1860

ggcuuugggg cacagggacc uaaagguggc agcggguccg gacccacaau cgaggaagug     1920

gauuga                                                                1926


<210>  1950
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HS71B__Homo_sapiens__AAA63227

<400>  1950
auggccaagg ccgccgccau cggcaucgac cugggcacca ccuacagcug cgugggcgug       60

uuccagcacg gcaaggugga gaucaucgcc aacgaccagg gcaacagaac cacccccagc      120

uacguggccu ucaccgacac cgagagacug aucggcgacg ccgccaagaa ccagguggcc      180

cugaaccccc agaacaccgu guucgacgcc aagagacuga ucggcagaaa guucggcgac      240

cccguggugc agagcgacau gaagcacugg cccuuccagg ugaucaacga cggcgacaag      300

cccaaggugc aggugagcua caagggcgag accaaggccu ucuaccccga ggagaucagc      360

agcauggugc ugaccaagau gaaggagauc gccgaggccu accugggcua ccccgugacc      420

aacgccguga ucaccgugcc cgccuacuuc aacgacagcc agagacaggc caccaaggac      480

gccggcguga ucgccggccu gaacgugcug agaaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccuggacag aaccggcaag ggcgagagaa acgugcugau cuucgaccug      600

ggcggcggca ccuucgacgu gagcauccug accaucgacg acggcaucuu cgaggugaag      660

gccaccgccg gcgacaccca ccugggcggc gaggacuucg acaacagacu ggugaaccac      720

uucguggagg aguucaagag aaagcacaag aaggacauca gccagaacaa gagagccgug      780

agaagacuga gaaccgccug cgagagagcc aagagaaccc ugagcagcag cacccaggcc      840

agccuggaga ucgacagccu guucgagggc aucgacuucu acaccagcau caccagagcc      900

agauucgagg agcugugcag cgaccuguuc agaagcaccc uggagcccgu ggagaaggcc      960

cugagagacg ccaagcugga caaggcccag auccacgacc uggugcuggu gggcggcagc     1020

accagaaucc ccaaggugca gaagcugcug caggacuucu ucaacggcag agaccugaac     1080

aagagcauca accccgacga ggccguggcc uacggcgccg ccgugcaggc cgccauccug     1140

augggcgaca agagcgagaa cgugcaggac cugcugcugc uggacguggc cccccugagc     1200

cugggccugg agaccgccgg cggcgugaug accgcccuga ucaagagaaa cagcaccauc     1260

cccaccaagc agacccagau cuucaccacc uacagcgaca accagcccgg cgugcugauc     1320

cagguguacg agggcgagag agccaugacc aaggacaaca accugcuggg cagauucgag     1380

cugagcggca ucccccccgc ccccagaggc gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgugaccgcc accgacaaga gcaccggcaa ggccaacaag     1500

aucaccauca ccaacgacaa gggcagacug agcaaggagg agaucgagag aauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag gugcagagag agagagugag cgccaagaac     1620

gcccuggaga gcuacgccuu caacaugaag agcgccgugg aggacgaggg ccugaagggc     1680

aagaucagcg aggccgacaa gaagaaggug cuggacaagu gccaggaggu gaucagcugg     1740

cuggacgcca acacccuggc cgagaaggac gaguucgagc acaagagaaa ggagcuggag     1800

caggugugca accccaucau cagcggccug uaccagggcg ccggcggccc cggccccggc     1860

ggcuucggcg cccagggccc caagggcggc agcggcagcg gccccaccau cgaggaggug     1920

gacuga                                                                1926


<210>  1951
<211>  1926
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HS71B__Homo_sapiens__AAA63227

<400>  1951
auggccaagg cugccgcgau cggcauugac cuggggacca cauacagcug cgugggaguc       60

uuccagcacg gcaaaguuga gaucauugcu aacgaucaag ggaauagaac gacccccucc      120

uauguggccu uuacagacac cgaacggcuc aucggagaug ccgcuaagaa ccagguggcc      180

cugaauccuc agaacacagu cuucgacgcu aaacgccuua uuggcagaaa guuuggggau      240

ccggugguuc agucugacau gaaacauugg cccuuccaag ugaucaauga uggagacaag      300

ccuaaggucc aggugagcua caaaggcgag accaaggccu uuuaucccga agagaucucc      360

ucuaugguuc ugacaaaaau gaaggaaauu gcggaggccu accucggcua uccugugacc      420

aacgcuguca ucacggugcc cgccuacuuc aaugauagcc agcggcaggc uaccaaagac      480

gccgggguga uugcgggacu gaacguccuu cgcaucauua augagccuac agccgcugcc      540

aucgcuuaug gccuggauag aaccgggaag ggagaacgga acguucucau uuuugaccug      600

ggcgggggaa cauucgaugu guccauccug accaucgacg acggcauuuu ugaggugaag      660

gccacggccg gcgauacaca ccucggggga gaagacuucg auaaucgccu ggucaaccau      720

uuuguggagg aguucaaaag aaagcacaaa aaggacaucu cucaaaauaa acgggcuguu      780

cgcagacuuc ggaccgcgug ugaacgcgcc aagagaacac ugagcuccag cacccaggcu      840

ucucucgaga uugauucccu guuugaaggc aucgacuucu acaccagcau uacacgggcc      900

cgcuucgagg aacuuugcuc ugaucuguuu agauccacgc ucgagccggu ggagaaagcc      960

cugcgggacg cuaagcugga uaaggcccag auccaugacc ucguccuggu ugggggaagc     1020

accagaaucc ccaaagugca gaaacuucug caagauuucu uuaacggccg cgaccucaau     1080

aagucuauua acccugacga agcgguggcu uacggggccg ccguccaggc ugccauccug     1140

augggagaua aguccgagaa cgugcaggac cuucugcucc uggaugucgc uccccugagc     1200

cucggccugg aaacagccgg cggggugaug accgcgcuua uuaaacggaa uagcacaauc     1260

ccuaccaagc aaacgcagau uuucacaacc uauucugaca accagcccgg aguucugauc     1320

cagguguacg agggcgaaag agccaugacc aaggauaaua accuccuggg gcgcuuugag     1380

cuuagcggaa ucccgccugc uccccggggc gucccucaaa uugaggugac auucgacauc     1440

gaugccaaug ggauucugaa cguuaccgcu acagacaaau ccacgggcaa ggccaauaaa     1500

aucaccauua caaacgauaa gggaagacuc agcaaagaag agaucgaacg cauggugcag     1560

gaggcggaaa aguauaaggc cgaggacgag guccagcggg aaagaguguc ugcuaaaaau     1620

gcccuggagu ccuacgcuuu uaacaugaag uccgccgugg aagaugaggg ccugaaaggg     1680

aagauuucug aggccgacaa aaagaagguu cucgauaaau gucaggaagu caucagcugg     1740

cuggacgcua auacccuugc ggagaaggac gaguucgaac acaaacgcaa ggaacuggag     1800

caagugugca accccaucau uuccggacuc uaucagggcg ccgggggacc cggcccuggg     1860

ggcuuuggag cucagggccc gaaaggggga ucuggcagcg ggcccacaau cgaggaagug     1920

gauuga                                                                1926


<210>  1952
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HST-2__Homo_sapiens__P10767

<400>  1952

Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             






<210>  1953
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HST-2__Homo_sapiens__AAI21098

<400>  1953
auggcccugg gacagaaacu guucaucacu augucccggg gagcaggacg ucugcagggc       60

acgcuguggg cucucgucuu ccuaggcauc cuagugggca ugguggugcc cucgccugca      120

ggcacccgug ccaacaacac gcugcuggac ucgaggggcu ggggcacccu gcuguccagg      180

ucucgcgcgg ggcuagcugg agagauugcc ggggugaacu gggaaagugg cuauuuggug      240

gggaucaagc ggcagcggag gcucuacugc aacgugggca ucggcuuuca ccuccaggug      300

cuccccgacg gccggaucag cggaacccac gaggagaacc ccuacagccu gcuggaaauu      360

uccaccgugg agcgaggcgu ggugagucuc uuuggaguga gaagugcccu cuucgucgcc      420

augaacagua aaggaagauu guacgcaacg cccagcuucc aagaagaaug caaguucaga      480

gaaacccucc ugcccaacaa uuacaaugcc uacgagucag acuuguacca agggaccuac      540

auugcccuga gcaaauacgg acggguaaag cggggcagca aggugucccc gaucaugacu      600

gucacucauu uccuucccag gaucuaa                                          627


<210>  1954
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HST-2__Homo_sapiens__AAI21098

<400>  1954
auggcccugg gccagaagcu guucaucacc augagccgcg gggccggccg gcugcagggg       60

acccuguggg cgcucguguu ccugggcauc cuggucggga ugguggugcc cuccccggcc      120

ggcacgcgcg ccaacaacac ccuccuggac agccggggcu gggggacccu gcucucccgc      180

agccgggccg gccuggccgg ggagaucgcg ggcgucaacu gggaguccgg guaccuggug      240

ggcaucaagc gccagcggcg ccucuacugc aacgugggca ucggguucca ccuccagguc      300

cugcccgacg gccggaucag cgggacccac gaggagaacc ccuacucccu ccuggagauc      360

agcacggugg agcgcggcgu ggucucccug uucggcgugc ggagcgcccu cuucguggcc      420

augaacucca aggggcgccu guacgccacc cccagcuucc aggaggagug caaguuccgg      480

gagacccugc ucccgaacaa cuacaacgcg uacgaguccg accuguacca gggcaccuac      540

aucgcccuga gcaaguacgg gcgcgucaag cggggcucca aggugagccc caucaugacg      600

gugacccacu uccucccccg caucuga                                          627


<210>  1955
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HST-2__Homo_sapiens__AAI21098

<400>  1955
auggcccucg gccagaagcu cuucaucacc augucccgcg gcgccggccg ccuccagggc       60

acccucuggg cccucgucuu ccucggcauc cucgucggca uggucguccc cucccccgcc      120

ggcacccgcg ccaacaacac ccuccucgac ucccgcggcu ggggcacccu ccucucccgc      180

ucccgcgccg gccucgccgg cgagaucgcc ggcgucaacu gggaguccgg cuaccucguc      240

ggcaucaagc gccagcgccg ccucuacugc aacgucggca ucggcuucca ccuccagguc      300

cuccccgacg gccgcaucuc cggcacccac gaggagaacc ccuacucccu ccucgagauc      360

uccaccgucg agcgcggcgu cgucucccuc uucggcgucc gcuccgcccu cuucgucgcc      420

augaacucca agggccgccu cuacgccacc cccuccuucc aggaggagug caaguuccgc      480

gagacccucc uccccaacaa cuacaacgcc uacgaguccg accucuacca gggcaccuac      540

aucgcccucu ccaaguacgg ccgcgucaag cgcggcucca aggucucccc caucaugacc      600

gucacccacu uccucccccg caucuga                                          627


<210>  1956
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HST-2__Homo_sapiens__AAI21098

<400>  1956
auggcccugg gccagaagcu guucaucacc augagcagag gggcuggaag gcuucaaggu       60

acacuguggg cauugguguu uuuaggcauu cuggucggga ugguugugcc cuccccugcc      120

ggaacucggg cgaacaauac gcuacucgac ucucgcggcu gggguacccu gcuuucacga      180

agucgugcug ggcuggccgg agagauagca ggcguaaacu gggaaagcgg cuacuuggug      240

gggaucaaaa gacagaggcg gcucuauugc aaugucggaa uugguuucca ccuccaggug      300

cugccagaug gccgcaucuc cgggacacau gaggaaaacc cguacucucu cuuagagauu      360

ucgacuguug aaagaggagu ggucucacug uuuggcguga ggagcgcccu uuucguagcu      420

augaauagua agggucgguu guaugcaacc cccuccuuuc aggaggagug uaaauuccgc      480

gaaacacugc uaccuaacaa uuacaacgcc uaugagucug accucuacca agggaccuau      540

aucgcucuga gcaaguacgg acgaguuaaa agaggcucca aggugucacc aauaaugacu      600

gucacacacu uucuucccag gaucuga                                          627


<210>  1957
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HST-2__Homo_sapiens__AAI21098

<400>  1957
auggcccugg gccagaagcu guucaucacc augagcagag gcgccggcag acugcagggc       60

acccuguggg cccugguguu ccugggcauc cuggugggca ugguggugcc cagccccgcc      120

ggcaccagag ccaacaacac ccugcuggac agcagaggcu ggggcacccu gcugagcaga      180

agcagagccg gccuggccgg cgagaucgcc ggcgugaacu gggagagcgg cuaccuggug      240

ggcaucaaga gacagagaag acuguacugc aacgugggca ucggcuucca ccugcaggug      300

cugcccgacg gcagaaucag cggcacccac gaggagaacc ccuacagccu gcuggagauc      360

agcaccgugg agagaggcgu ggugagccug uucggcguga gaagcgcccu guucguggcc      420

augaacagca agggcagacu guacgccacc cccagcuucc aggaggagug caaguucaga      480

gagacccugc ugcccaacaa cuacaacgcc uacgagagcg accuguacca gggcaccuac      540

aucgcccuga gcaaguacgg cagagugaag agaggcagca aggugagccc caucaugacc      600

gugacccacu uccugcccag aaucuga                                          627


<210>  1958
<211>  627
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HST-2__Homo_sapiens__AAI21098

<400>  1958
auggcccugg gccagaaacu cuucaucacc augagcagag gggcuggacg gcugcaaggc       60

acacuuuggg cccugguguu ucucgggauu cuggucggaa ugguugugcc cuccccugcg      120

ggcacgcgcg cuaacaauac ccuucuggac ucuagagggu ggggaacacu ccugagccgg      180

ucccgcgccg gccuggccgg cgagaucgcu ggggugaacu gggaaucugg auaccucguc      240

ggcauuaaga gacagcggcg ccuguauugc aaugugggga ucggauucca ccuucagguu      300

cugccggaug gcagaauuag cgggacccau gaggaaaacc ccuacucccu ccuggagauc      360

ucuacagugg aacggggagu cgugagccuu uuuggcguuc gcuccgcccu guucguggcu      420

augaauagca agggcagacu cuaugccacc ccuucuuuuc aggaggagug uaaauuccgg      480

gaaacacugc ugcccaacaa uuacaacgcg uaugaguccg accucuacca agggaccuau      540

aucgcccuga gcaaguacgg acgcgucaaa agaggcucua aggugucccc uauuaugacg      600

gugacccacu uucuuccccg gaucuga                                          627


<210>  1959
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hTERT__Homo_sapiens__O94807

<400>  1959

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ile Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Ser Pro Gly Cys Gln Gly Leu Pro Ala Gly Cys Pro Ala Cys Pro Ser 
    370                 375                 380                 


Ala Thr Gly Lys Cys Gly Pro Cys Phe Trp Ser Cys Leu Gly Thr Thr 
385                 390                 395                 400 


Arg Ser Ala Pro Thr Gly Cys Ser Ser Arg Arg Thr Ala Arg Cys Glu 
                405                 410                 415     


Leu Arg Ser Pro Gln Gln Pro Val Ser Val Pro Gly Arg Ser Pro Arg 
            420                 425                 430         


Ala Leu Trp Arg Pro Pro Arg Arg Arg Thr Gln Thr Pro Val Ala Trp 
        435                 440                 445             


Cys Ser Cys Ser Ala Ser Thr Ala Pro Leu Ala Gly Val Arg Leu Arg 
    450                 455                 460                 


Ala Gly Leu Pro Ala Pro Ala Gly Ala Pro Arg Pro Leu Gly Leu Gln 
465                 470                 475                 480 


Ala Gln Arg Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu 
                485                 490                 495     


Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser 
            500                 505                 510         


Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro 
        515                 520             


<210>  1960
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  hTERT__Homo_sapiens__BAA74724

<400>  1960
augccgcgcg cuccccgcug ccgagccgug cgcucccugc ugcgcagcca cuaccgcgag       60

gugcugccgc uggccacguu cgugcggcgc cuggggcccc agggcuggcg gcuggugcag      120

cgcggggacc cggcggcuuu ccgcgcgcug guggcccagu gccuggugug cgugcccugg      180

gacgcacggc cgccccccgc cgcccccucc uuccgccagg uguccugccu gaaggagcug      240

guggcccgag ugcugcagag gcugugcgag cgcggcgcga agaacgugcu ggccuucggc      300

uucgcgcugc uggacggggc ccgcgggggc ccccccgagg ccuucaccac cagcgugcgc      360

agcuaccugc ccaacacggu gaccgacgca cugcggggga gcggggcgug ggggcugcug      420

uugcgccgcg ugggcgacga cgugcugguu caccugcugg cacgcugcgc gcucuuugug      480

cugguggcuc ccagcugcgc cuaccaggug ugcgggccgc cgcuguacca gcucggcgcu      540

gccacucagg cccggccccc gccacacgcu aguggacccc gaaggcgucu gggaugcgaa      600

cgggccugga accauagcgu cagggaggcc gggguccccc ugggccugcc agccccgggu      660

gcgaggaggc gcgggggcag ugccagccga agucugccgu ugcccaagag gcccaggcgu      720

ggcgcugccc cugagccgga gcggacgccc guugggcagg gguccugggc ccacccgggc      780

aggacgcgug gaccgaguga ccgugguuuc uguguggugu caccugccag acccgccgaa      840

gaagccaccu cuuuggaggg ugcgcucucu ggcacgcgcc acucccaccc auccgugggc      900

cgccagcacc acgcgggccc cccauccaca ucgcggccac cacgucccug ggacacgccu      960

ugucccccgg uguacgccga gaccaagcac uuccucuacu ccucaggcga caaggagcag     1020

cugcggcccu ccuuccuacu cagcucucug aggcccaucc ugacuggcgc ucggaggcuc     1080

guggagacca ucuuucuggg uuccagcccu ggaugccagg gacuccccgc agguugcccc     1140

gccugcccca gcgcuacugg caaaugcggc cccuguuucu ggagcugcuu gggaaccacg     1200

cgcagugccc cuacggggug cuccucaaga cgcacugccc gcugcgagcu gcggucaccc     1260

cagcagccgg ugucugugcc cgggagaagc cccagggcuc uguggcggcc cccgaggagg     1320

aggacacaga cccccgucgc cuggugcagc ugcuccgcca gcacagcacc ccuggcaggu     1380

guacggcuuc gugcgggccu gccugcgccg gcuggugccc ccaggccucu ggggcuccag     1440

gcacaacgac gccgcuuccu caggaacacc aagaaguuca ucucccuggg gaagcaugcc     1500

aagcucucgc ugcaggagcu gacguggaag augagcgugc gggacugcgc uuggcugcgc     1560

aggagccca                                                             1569


<210>  1961
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       hTERT__Homo_sapiens__BAA74724

<400>  1961
augccccgcg ccccgcggug ccgcgccgug cggagccugc uccgcuccca cuaccgggag       60

guccugcccc uggcgaccuu cgugcgccgg cucggccccc agggguggcg ccuggugcag      120

cggggcgacc ccgccgccuu ccgcgcccug gucgcccagu gccucgugug cgugccgugg      180

gacgcgcggc ccccgcccgc cgcccccagc uuccgccagg ucuccugccu gaaggagcug      240

guggcccggg ugcuccagcg ccugugcgag cgcggggcga agaacguccu ggccuucggc      300

uucgcccucc uggacggggc ccggggcggc ccgcccgagg ccuucaccac gagcgugcgg      360

uccuaccugc ccaacaccgu gaccgacgcg cuccgcggga gcggcgccug ggggcugcug      420

cuccggcgcg ucggcgacga cgugcuggug caccuccucg cccggugcgc ccuguucguc      480

cugguggccc ccuccugcgc guaccaggug ugcgggccgc cccucuacca gcugggcgcc      540

gccacccagg cccgcccgcc gccccacgcc agcggccccc gccggcgccu ggggugcgag      600

cgggcgugga accacuccgu ccgcgaggcc ggcgugcccc uggggcugcc cgcccccggc      660

gcccggcgcc ggggcgggag cgccucccgc agccugcccc uccccaagcg gccccgccgg      720

ggcgcggccc ccgagcccga gcgcacgccc guggggcagg gcuccugggc ccacccgggg      780

cggacccgcg gccccagcga ccggggcuuc ugcgucgugu cccccgcccg cccggcggag      840

gaggccacca gccuggaggg ggcccugucc ggcacccggc acagccaccc cuccgugggg      900

cgccagcacc acgccggccc gcccagcacg agccggccgc cccgccccug ggacaccccc      960

ugcccgcccg ucuacgccga gaccaagcac uuccucuacu ccagcgggga caaggagcag     1020

cugcgccccu ccuuccugcu cagcucccug cggcccaucc ugaccggcgc gcgccggcuc     1080

guggagacga ucuuccuggg cagcuccccc gggugccagg gccugcccgc cgggugcccc     1140

gccugcccca gcgccaccgg caagugcggg ccgugcuucu gguccugccu cggcaccacc     1200

cgcagcgccc ccacgggcug cuccagccgg cgcaccgcgc ggugcgagcu gcgcagcccc     1260

cagcagcccg ucuccgugcc ggggcggagc ccccgcgccc uguggcggcc gccccgccgg     1320

cgcacccaga cccccguggc cuggugcucc ugcuccgcca gcacggcgcc ccucgccggc     1380

guccggcugc gcgccgggcu gcccgccccg gccggcgcgc cccggccccu cggccugcag     1440

gcccagcgcc ggcgcuuccu gcggaacacc aagaaguuca ucucccuggg gaagcacgcc     1500

aagcucagcc ugcaggagcu gaccuggaag augagcgugc gcgacugcgc cuggcuccgc     1560

cgguccccc                                                             1569


<210>  1962
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       hTERT__Homo_sapiens__BAA74724

<400>  1962
augccccgcg ccccccgcug ccgcgccguc cgcucccucc uccgcuccca cuaccgcgag       60

guccuccccc ucgccaccuu cguccgccgc cucggccccc agggcuggcg ccucguccag      120

cgcggcgacc ccgccgccuu ccgcgcccuc gucgcccagu gccucgucug cguccccugg      180

gacgcccgcc ccccccccgc cgcccccucc uuccgccagg ucuccugccu caaggagcuc      240

gucgcccgcg uccuccagcg ccucugcgag cgcggcgcca agaacguccu cgccuucggc      300

uucgcccucc ucgacggcgc ccgcggcggc ccccccgagg ccuucaccac cuccguccgc      360

uccuaccucc ccaacaccgu caccgacgcc cuccgcggcu ccggcgccug gggccuccuc      420

cuccgccgcg ucggcgacga cguccucguc caccuccucg cccgcugcgc ccucuucguc      480

cucgucgccc ccuccugcgc cuaccagguc ugcggccccc cccucuacca gcucggcgcc      540

gccacccagg cccgcccccc cccccacgcc uccggccccc gccgccgccu cggcugcgag      600

cgcgccugga accacuccgu ccgcgaggcc ggcguccccc ucggccuccc cgcccccggc      660

gcccgccgcc gcggcggcuc cgccucccgc ucccuccccc uccccaagcg cccccgccgc      720

ggcgccgccc ccgagcccga gcgcaccccc gucggccagg gcuccugggc ccaccccggc      780

cgcacccgcg gccccuccga ccgcggcuuc ugcgucgucu cccccgcccg ccccgccgag      840

gaggccaccu cccucgaggg cgcccucucc ggcacccgcc acucccaccc cuccgucggc      900

cgccagcacc acgccggccc ccccuccacc ucccgccccc cccgccccug ggacaccccc      960

ugcccccccg ucuacgccga gaccaagcac uuccucuacu ccuccggcga caaggagcag     1020

cuccgccccu ccuuccuccu cuccucccuc cgccccaucc ucaccggcgc ccgccgccuc     1080

gucgagacca ucuuccucgg cuccuccccc ggcugccagg gccuccccgc cggcugcccc     1140

gccugccccu ccgccaccgg caagugcggc cccugcuucu gguccugccu cggcaccacc     1200

cgcuccgccc ccaccggcug cuccucccgc cgcaccgccc gcugcgagcu ccgcuccccc     1260

cagcagcccg ucuccguccc cggccgcucc ccccgcgccc ucuggcgccc cccccgccgc     1320

cgcacccaga cccccgucgc cuggugcucc ugcuccgccu ccaccgcccc ccucgccggc     1380

guccgccucc gcgccggccu ccccgccccc gccggcgccc cccgcccccu cggccuccag     1440

gcccagcgcc gccgcuuccu ccgcaacacc aagaaguuca ucucccucgg caagcacgcc     1500

aagcucuccc uccaggagcu caccuggaag auguccgucc gcgacugcgc cuggcuccgc     1560

cgcuccccc                                                             1569


<210>  1963
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       hTERT__Homo_sapiens__BAA74724

<400>  1963
augcccagag ccccuaggug ccgggcugug cgcagccugc uccgauccca cuaccgugag       60

guccuuccac uggcaaccuu cguuagaagg uugggcccgc agggguggcg guuagugcaa      120

cgcggagacc ccgccgcguu uagagcucug guagcccagu gucuagugug cgucccuugg      180

gaugcaaggc cacccccugc cgcuccaucu uuccgccagg ugucaugucu caaggaacug      240

guugcacggg ugcuucagcg acugugcgag agaggugcca aaaacgucuu ggcuuuuggc      300

uucgcccucc uggacggggc gaggggaggu cccccugaag cauuuacaac gagugugcgg      360

agcuaucugc caaauacugu aaccgaugcc cuccguggcu ccggggcuug gggauuacug      420

cuucgcagag uuggcgacga uguguugguc caucugcuag ccaggugugc acucuucgug      480

cugguggcuc cgucuugcgc cuaccaaguc ugugggcccc cucuuuauca gcugggcgcg      540

gccacacagg cacggccacc cccucacgcu ucgggaccac gacgcagauu ggguugcgag      600

agggccugga accauucagu ucgggaagcu ggcgugcccc ucgggcugcc ggccccugga      660

gcacgcagaa ggggcgguag cgccagucgu uccuuacccc ugccaaagcg gccucgaaga      720

ggggcugcgc ccgagccaga gaggacuccc guaggacagg gcucuugggc acacccuggc      780

cgcacccggg ggccaagcga cagaggauuu uguguggucu ccccggccag gcccgcugaa      840

gaggccacau cacucgaagg ugcacuuagu ggcacccgcc auagccaccc uucugugggg      900

cgacaacacc augccggacc acccuccacu ucacggccuc cacgucccug ggauacaccg      960

ugcccuccag uuuacgcuga gaccaaacac uuccuguaua gcaguggcga caaggagcag     1020

uugagacccu cuuuucuacu guccagccuc aggccuaucc ugacgggugc ccgccggcuu     1080

guggaaacua uuuuccuggg gucgucuccc ggcugucagg gauugccagc aggcugcccu     1140

gcgugccccu ccgcuaccgg gaaaugugga ccaugcuuuu ggucaugucu cgguacaacu     1200

agaagugccc cgaccggcug cagcuccagg cgaacagcac gcugugagcu gcggucuccu     1260

cagcaacccg ucagcgugcc agggagauca cccagggccu uauggcgucc uccacgccgg     1320

agaacccaga cgcccguagc uuggugcagu uguuccgcca gcacugcacc ucuggcugga     1380

guuaggcuac gagccggccu cccggcgcca gccggugcuc cccggccucu ggggcuucag     1440

gcacaacgca gaagguucuu gcggaauaca aagaaguuua uaucucuggg caaacaugcc     1500

aagcucucac ugcaggaacu uaccuggaaa augagugugc gagauugcgc uuggcugaga     1560

cgcagccca                                                             1569


<210>  1964
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       hTERT__Homo_sapiens__BAA74724

<400>  1964
augcccagag cccccagaug cagagccgug agaagccugc ugagaagcca cuacagagag       60

gugcugcccc uggccaccuu cgugagaaga cugggccccc agggcuggag acuggugcag      120

agaggcgacc ccgccgccuu cagagcccug guggcccagu gccuggugug cgugcccugg      180

gacgccagac ccccccccgc cgcccccagc uucagacagg ugagcugccu gaaggagcug      240

guggccagag ugcugcagag acugugcgag agaggcgcca agaacgugcu ggccuucggc      300

uucgcccugc uggacggcgc cagaggcggc ccccccgagg ccuucaccac cagcgugaga      360

agcuaccugc ccaacaccgu gaccgacgcc cugagaggca gcggcgccug gggccugcug      420

cugagaagag ugggcgacga cgugcuggug caccugcugg ccagaugcgc ccuguucgug      480

cugguggccc ccagcugcgc cuaccaggug ugcggccccc cccuguacca gcugggcgcc      540

gccacccagg ccagaccccc cccccacgcc agcggcccca gaagaagacu gggcugcgag      600

agagccugga accacagcgu gagagaggcc ggcgugcccc ugggccugcc cgcccccggc      660

gccagaagaa gaggcggcag cgccagcaga agccugcccc ugcccaagag acccagaaga      720

ggcgccgccc ccgagcccga gagaaccccc gugggccagg gcagcugggc ccaccccggc      780

agaaccagag gccccagcga cagaggcuuc ugcgugguga gccccgccag acccgccgag      840

gaggccacca gccuggaggg cgcccugagc ggcaccagac acagccaccc cagcgugggc      900

agacagcacc acgccggccc ccccagcacc agcagacccc ccagacccug ggacaccccc      960

ugcccccccg uguacgccga gaccaagcac uuccuguaca gcagcggcga caaggagcag     1020

cugagaccca gcuuccugcu gagcagccug agacccaucc ugaccggcgc cagaagacug     1080

guggagacca ucuuccuggg cagcagcccc ggcugccagg gccugcccgc cggcugcccc     1140

gccugcccca gcgccaccgg caagugcggc cccugcuucu ggagcugccu gggcaccacc     1200

agaagcgccc ccaccggcug cagcagcaga agaaccgcca gaugcgagcu gagaagcccc     1260

cagcagcccg ugagcgugcc cggcagaagc cccagagccc uguggagacc ccccagaaga     1320

agaacccaga cccccguggc cuggugcagc ugcagcgcca gcaccgcccc ccuggccggc     1380

gugagacuga gagccggccu gcccgccccc gccggcgccc ccagaccccu gggccugcag     1440

gcccagagaa gaagauuccu gagaaacacc aagaaguuca ucagccuggg caagcacgcc     1500

aagcugagcc ugcaggagcu gaccuggaag augagcguga gagacugcgc cuggcugaga     1560

agaagcccc                                                             1569


<210>  1965
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       hTERT__Homo_sapiens__BAA74724

<400>  1965
augcccagag ccccucggug ccgcgcugug agaagccugc uccgguccca cuaccgcgag       60

guccugccgc uugccaccuu cguuagacgg cugggccccc agggguggcg ccucgugcaa      120

agaggagacc cugcggcuuu ucgggcccug guggcccagu gucuugucug cgugcccugg      180

gaugcucgcc cucccccugc cgcuccgucu uucagacagg uuagcugucu gaaggaacuc      240

guggcccggg uccugcagcg ccugugcgag agaggcgcga aaaacgugcu cgccuuuggg      300

uucgcucugc uugacggagc ccggggcggg cccccugaag ccuuuacaac guccguucgc      360

ucuuaucugc ccaauaccgu gacagaugcc cucagaggaa gcggcgcgug gggccugcuu      420

cugcggagag ucggggacga ugugcucgug caucugcugg cccgcugugc ucucuucguc      480

cugguugccc cuuccugcgc uuaccaagug uguggacccc cgcuuuauca gcugggcgcc      540

gccacccagg cucggccucc cccucacgcg ucugggccca gacgccggcu cggaugcgag      600

agagccugga accauagcgu gcgcgaagcu ggcguccccc uggggcuucc ugccccggga      660

gcccggagac gcggcggcuc cgcuagccgg ucucugcccc ucccuaagag accccgccgg      720

ggcgccgcgc cugagcccga gagaacaccg gugggacagg gcuccugggc ucacccuggg      780

cggacccgcg gacccagcga cagaggcuuu uguguugugu cuccugcccg gcccgccgaa      840

gaggcuacau cccuggaagg ggcccugagc ggaaccagac auucucaccc uuccgucggc      900

cgccaacacc augcugggcc cccgagcacg ucccggccuc ccagacccug ggauaccccu      960

ugcccgcccg uguacgccga gacaaaacac uuccucuauu cuagcgggga caaggagcag     1020

cugcgcccuu ccuuucuucu gagcucucuc agacccaucc ugaccggagc gcggcgccuu     1080

guugaaacaa uuuuccuggg cuccagcccu gggugucagg gacuccccgc cggcugcccu     1140

gcuugccccu cugccaccgg gaaauguggc ccgugcuuuu ggagcugucu gggaacgaca     1200

agauccgcuc cuaccggcug cucuagccgg cgcacagcca gaugugagcu gcggagcccc     1260

cagcaaccug uguccguccc cgggcgcucu ccgagagcgc ucuggcggcc uccccgcaga     1320

cggacccaga ccccuguggc cuggugcucc uguagcgcuu cuacagcucc ccuggcugga     1380

gucagacuuc gcgccggccu gcccgccccu gcuggggcgc cgcggccccu cggacugcag     1440

gcccaaagac gccgguuccu gagaaauacg aagaaguuua ucucccuugg caaacaugcu     1500

aagcucagcc ugcaggaacu gaccuggaaa auguccgugc gcgauugcgc cuggcuccgg     1560

agaucuccu                                                             1569


<210>  1966
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  iCE__Homo_sapiens__O00748

<400>  1966

Met Arg Leu His Arg Leu Arg Ala Arg Leu Ser Ala Val Ala Cys Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Arg Gly Gln Gly Gln Asp Ser Ala Ser Pro 
            20                  25                  30          


Ile Arg Thr Thr His Thr Gly Gln Val Leu Gly Ser Leu Val His Val 
        35                  40                  45              


Lys Gly Ala Asn Ala Gly Val Gln Thr Phe Leu Gly Ile Pro Phe Ala 
    50                  55                  60                  


Lys Pro Pro Leu Gly Pro Leu Arg Phe Ala Pro Pro Glu Pro Pro Glu 
65                  70                  75                  80  


Ser Trp Ser Gly Val Arg Asp Gly Thr Thr His Pro Ala Met Cys Leu 
                85                  90                  95      


Gln Asp Leu Thr Ala Val Glu Ser Glu Phe Leu Ser Gln Phe Asn Met 
            100                 105                 110         


Thr Phe Pro Ser Asp Ser Met Ser Glu Asp Cys Leu Tyr Leu Ser Ile 
        115                 120                 125             


Tyr Thr Pro Ala His Ser His Glu Gly Ser Asn Leu Pro Val Met Val 
    130                 135                 140                 


Trp Ile His Gly Gly Ala Leu Val Phe Gly Met Ala Ser Leu Tyr Asp 
145                 150                 155                 160 


Gly Ser Met Leu Ala Ala Leu Glu Asn Val Val Val Val Ile Ile Gln 
                165                 170                 175     


Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Lys His Ala 
            180                 185                 190         


Thr Gly Asn Trp Gly Tyr Leu Asp Gln Val Ala Ala Leu Arg Trp Val 
        195                 200                 205             


Gln Gln Asn Ile Ala His Phe Gly Gly Asn Pro Asp Arg Val Thr Ile 
    210                 215                 220                 


Phe Gly Glu Ser Ala Gly Gly Thr Ser Val Ser Ser Leu Val Val Ser 
225                 230                 235                 240 


Pro Ile Ser Gln Gly Leu Phe His Gly Ala Ile Met Glu Ser Gly Val 
                245                 250                 255     


Ala Leu Leu Pro Gly Leu Ile Ala Ser Ser Ala Asp Val Ile Ser Thr 
            260                 265                 270         


Val Val Ala Asn Leu Ser Ala Cys Asp Gln Val Asp Ser Glu Ala Leu 
        275                 280                 285             


Val Gly Cys Leu Arg Gly Lys Ser Lys Glu Glu Ile Leu Ala Ile Asn 
    290                 295                 300                 


Lys Pro Phe Lys Met Ile Pro Gly Val Val Asp Gly Val Phe Leu Pro 
305                 310                 315                 320 


Arg His Pro Gln Glu Leu Leu Ala Ser Ala Asp Phe Gln Pro Val Pro 
                325                 330                 335     


Ser Ile Val Gly Val Asn Asn Asn Glu Phe Gly Trp Leu Ile Pro Lys 
            340                 345                 350         


Val Met Arg Ile Tyr Asp Thr Gln Lys Glu Met Asp Arg Glu Ala Ser 
        355                 360                 365             


Gln Ala Ala Leu Gln Lys Met Leu Thr Leu Leu Met Leu Pro Pro Thr 
    370                 375                 380                 


Phe Gly Asp Leu Leu Arg Glu Glu Tyr Ile Gly Asp Asn Gly Asp Pro 
385                 390                 395                 400 


Gln Thr Leu Gln Ala Gln Phe Gln Glu Met Met Ala Asp Ser Met Phe 
                405                 410                 415     


Val Ile Pro Ala Leu Gln Val Ala His Phe Gln Cys Ser Arg Ala Pro 
            420                 425                 430         


Val Tyr Phe Tyr Glu Phe Gln His Gln Pro Ser Trp Leu Lys Asn Ile 
        435                 440                 445             


Arg Pro Pro His Met Lys Ala Asp His Gly Asp Glu Leu Pro Phe Val 
    450                 455                 460                 


Phe Arg Ser Phe Phe Gly Gly Asn Tyr Ile Lys Phe Thr Glu Glu Glu 
465                 470                 475                 480 


Glu Gln Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Asn Phe Ala Arg 
                485                 490                 495     


Asn Gly Asn Pro Asn Gly Glu Gly Leu Pro His Trp Pro Leu Phe Asp 
            500                 505                 510         


Gln Glu Glu Gln Tyr Leu Gln Leu Asn Leu Gln Pro Ala Val Gly Arg 
        515                 520                 525             


Ala Leu Lys Ala His Arg Leu Gln Phe Trp Lys Lys Ala Leu Pro Gln 
    530                 535                 540                 


Lys Ile Gln Glu Leu Glu Glu Pro Glu Glu Arg His Thr Glu Leu 
545                 550                 555                 


<210>  1967
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  iCE__Homo_sapiens__BAA23606

<400>  1967
augcggcugc acagacuucg ugcgcggcug agcgcggugg ccugugggcu ucugcugcuu       60

cuuguccggg gccagggcca ggacucagcc agucccaucc ggaccacaca cacggggcag      120

gugcugggga gucuugucca ugugaagggc gccaaugccg ggguccaaac cuuccuggga      180

auuccauuug ccaagccacc ucuagguccg cugcgauuug cacccccuga gcccccugaa      240

ucuuggagug gugugaggga uggaaccacc cauccggcca ugugucuaca ggaccucacc      300

gcaguggagu cagaguuucu uagccaguuc aacaugaccu ucccuuccga cuccaugucu      360

gaggacugcc uguaccucag caucuacacg ccggcccaua gccaugaagg cucuaaccug      420

ccggugaugg uguggaucca cgguggugcg cuuguuuuug gcauggcuuc cuuguaugau      480

gguuccaugc uggcugccuu ggagaacgug guggugguca ucauccagua ccgccugggu      540

guccugggcu ucuucagcac uggagacaag cacgcaaccg gcaacugggg cuaccuggac      600

caaguggcug cacuacgcug gguccagcag aauaucgccc acuuuggagg caacccugac      660

cgugucacca uuuuuggcga gucugcgggu ggcacgagug ugucuucgcu uguugugucc      720

cccauauccc aaggacucuu ccacggagcc aucauggaga guggcguggc ccuccugccc      780

ggccucauug ccagcucagc ugaugucauc uccacggugg uggccaaccu gucugccugu      840

gaccaaguug acucugaggc ccuggugggc ugccugcggg gcaagaguaa agaggagauu      900

cuugcaauua acaagccuuu caagaugauc cccggagugg uggauggggu cuuccugccc      960

aggcaccccc aggagcugcu ggccucugcc gacuuucagc cugucccuag cauuguuggu     1020

gucaacaaca augaauucgg cuggcucauc cccaagguca ugaggaucua ugauacccag     1080

aaggaaaugg acagagaggc cucccaggcu gcucugcaga aaauguuaac gcugcugaug     1140

uugccuccua cauuugguga ccugcugagg gaggaguaca uuggggacaa uggggauccc     1200

cagacccucc aagcgcaguu ccaggagaug auggcggacu ccauguuugu gaucccugca     1260

cuccaaguag cacauuuuca guguucccgg gccccugugu acuucuacga guuccagcau     1320

cagcccagcu ggcucaagaa caucaggcca ccgcacauga aggcagacca uggugaugag     1380

cuuccuuuug uuuucagaag uuucuuuggg ggcaacuaca uuaaauucac ugaggaagag     1440

gagcagcuaa gcaggaagau gaugaaguac ugggccaacu uugcgagaaa ugggaacccg     1500

aauggcgagg gucugccaca cuggccgcug uucgaccagg aggagcaaua ccugcagcug     1560

aaccuacagc cugcgguggg ccgggcucug aaggcccaca ggcuccaguu cuggaagaag     1620

gcgcugcccc aaaagaucca ggagcucgag gagccugaag agagacacac agagcuguag     1680


<210>  1968
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       iCE__Homo_sapiens__BAA23606

<400>  1968
augcgccugc accggcuccg cgcccggcug agcgccgugg cgugcggccu gcuccugcug       60

cucguccgcg ggcagggcca ggacuccgcc agccccaucc ggaccaccca cacgggccag      120

gugcuggggu cccuggugca cgucaagggg gccaacgccg gcgugcagac cuuccucggc      180

aucccguucg ccaagccgcc ccuggggccc cugcgcuucg cgccgcccga gccgcccgag      240

agcugguccg gcgugcggga cgggaccacc caccccgcca ugugccucca ggaccugacg      300

gccgucgaga gcgaguuccu gucccaguuc aacaugaccu uccccagcga cuccaugagc      360

gaggacugcc ucuaccuguc caucuacacc cccgcccaca gccacgaggg cuccaaccug      420

cccgugaugg uguggaucca cgggggcgcg cucgucuucg gcauggccag ccuguacgac      480

ggguccaugc uggccgcccu cgagaacgug guggucguga ucauccagua ccgccugggc      540

gugcuggggu ucuucagcac cggcgacaag cacgccacgg gcaacugggg guaccucgac      600

caggucgcgg cccugcggug ggugcagcag aacaucgccc acuucggcgg gaaccccgac      660

cgcgugacca ucuucggcga guccgccggg ggcaccagcg ucuccagccu gguggugagc      720

cccaucuccc agggccucuu ccacggggcc aucauggaga gcggcgucgc gcugcugccc      780

gggcucaucg ccuccagcgc cgacgugauc uccaccgugg ucgccaaccu gagcgccugc      840

gaccaggugg acuccgaggc gcuggucggc ugccuccggg gcaagagcaa ggaggagauc      900

cuggccauca acaagcccuu caagaugauc ccgggggugg uggacggcgu cuuccugccc      960

cgccaccccc aggagcuccu ggccuccgcc gacuuccagc ccgugccgag caucgugggg     1020

gucaacaaca acgaguucgg cuggcugauc cccaagguga ugcggaucua cgacacgcag     1080

aaggagaugg accgcgaggc cucccaggcg gcccuccaga agaugcugac ccugcucaug     1140

cugccgccca ccuucgggga ccugcuccgg gaggaguaca ucggcgacaa cggggacccc     1200

cagacccugc aggcccaguu ccaggagaug auggccgaca gcauguucgu gauccccgcg     1260

cugcaggucg cccacuucca gugcucccgc gcccccgugu acuucuacga guuccagcac     1320

cagcccagcu ggcucaagaa cauccggccg ccccacauga aggccgacca cggcgacgag     1380

cugcccuucg uguuccgcuc cuucuucggc gggaacuaca ucaaguucac ggaggaggag     1440

gagcagcuga gccggaagau gaugaaguac ugggccaacu ucgcgcgcaa cggcaacccg     1500

aacggggagg gccugcccca cuggccccuc uucgaccagg aggagcagua ccugcagcug     1560

aaccuccagc ccgccgucgg ccgggcccug aaggcccacc gccugcaguu cuggaagaag     1620

gcccucccgc agaagaucca ggagcuggag gagcccgagg agcgccacac cgagcuguga     1680


<210>  1969
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       iCE__Homo_sapiens__BAA23606

<400>  1969
augcgccucc accgccuccg cgcccgccuc uccgccgucg ccugcggccu ccuccuccuc       60

cucguccgcg gccagggcca ggacuccgcc ucccccaucc gcaccaccca caccggccag      120

guccucggcu cccucgucca cgucaagggc gccaacgccg gcguccagac cuuccucggc      180

auccccuucg ccaagccccc ccucggcccc cuccgcuucg ccccccccga gccccccgag      240

uccugguccg gcguccgcga cggcaccacc caccccgcca ugugccucca ggaccucacc      300

gccgucgagu ccgaguuccu cucccaguuc aacaugaccu uccccuccga cuccaugucc      360

gaggacugcc ucuaccucuc caucuacacc cccgcccacu cccacgaggg cuccaaccuc      420

cccgucaugg ucuggaucca cggcggcgcc cucgucuucg gcauggccuc ccucuacgac      480

ggcuccaugc ucgccgcccu cgagaacguc gucgucguca ucauccagua ccgccucggc      540

guccucggcu ucuucuccac cggcgacaag cacgccaccg gcaacugggg cuaccucgac      600

caggucgccg cccuccgcug gguccagcag aacaucgccc acuucggcgg caaccccgac      660

cgcgucacca ucuucggcga guccgccggc ggcaccuccg ucuccucccu cgucgucucc      720

cccaucuccc agggccucuu ccacggcgcc aucauggagu ccggcgucgc ccuccucccc      780

ggccucaucg ccuccuccgc cgacgucauc uccaccgucg ucgccaaccu cuccgccugc      840

gaccaggucg acuccgaggc ccucgucggc ugccuccgcg gcaaguccaa ggaggagauc      900

cucgccauca acaagcccuu caagaugauc cccggcgucg ucgacggcgu cuuccucccc      960

cgccaccccc aggagcuccu cgccuccgcc gacuuccagc ccguccccuc caucgucggc     1020

gucaacaaca acgaguucgg cuggcucauc cccaagguca ugcgcaucua cgacacccag     1080

aaggagaugg accgcgaggc cucccaggcc gcccuccaga agaugcucac ccuccucaug     1140

cuccccccca ccuucggcga ccuccuccgc gaggaguaca ucggcgacaa cggcgacccc     1200

cagacccucc aggcccaguu ccaggagaug auggccgacu ccauguucgu cauccccgcc     1260

cuccaggucg cccacuucca gugcucccgc gcccccgucu acuucuacga guuccagcac     1320

cagcccuccu ggcucaagaa cauccgcccc ccccacauga aggccgacca cggcgacgag     1380

cuccccuucg ucuuccgcuc cuucuucggc ggcaacuaca ucaaguucac cgaggaggag     1440

gagcagcucu cccgcaagau gaugaaguac ugggccaacu ucgcccgcaa cggcaacccc     1500

aacggcgagg gccuccccca cuggccccuc uucgaccagg aggagcagua ccuccagcuc     1560

aaccuccagc ccgccgucgg ccgcgcccuc aaggcccacc gccuccaguu cuggaagaag     1620

gcccuccccc agaagaucca ggagcucgag gagcccgagg agcgccacac cgagcucuga     1680


<210>  1970
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       iCE__Homo_sapiens__BAA23606

<400>  1970
augagacugc acaggcuccg ggcccgccuu agcgcugugg caugcggccu guuguuacug       60

cuaguccgag ggcagggaca agacuccgcc ucucccaucc guaccacaca uacuggucag      120

guucucggcu cacuggugca cguaaagggg gcgaacgcug gagugcagac guuccuuggc      180

auuccuuuug ccaaaccacc gcuggguccc uugagauucg caccuccaga gcccccugaa      240

aguuggagcg gggucaggga uggaaccaca cauccagcca ugugucucca ggaccugacu      300

gcuguggagu ccgaauuucu gucucaauuc aauaugaccu uucccucgga uucaaugagc      360

gaggacugcc ucuacuuaag uauauauacc ccugcacacu cccaugaagg cucuaaccug      420

ccaguuaugg uguggaucca cggcggggcc cuugucuucg gaauggcuag cuuguacgau      480

gguuccaugc uggccgcgcu agagaaugug guaguuguga uuauccagua ucggcucggc      540

guccuggggu uuuucucaac aggagacaag cacgcaacug gcaacugggg uuaccuugau      600

cagguggccg cucugcgcug ggugcagcaa aauauugccc auuuuggggg aaacccggac      660

agagucacaa ucuucggcga gagugcaggc gggaccagcg uuucuuccuu ggugguauca      720

cccauaagcc agggacucuu ucacggugcu aucauggaaa guggcguggc ccuguuaccu      780

gggcugauug cgucuuccgc cgaugucauc agcacggugg uugcaaaucu cucggcuugu      840

gaccaggugg auucugaggc ccuugucgga ugccugaggg gcaaauccaa ggaagagauu      900

uuggcuauca acaaaccauu caagaugaua cccggugugg uagacggggu uuuucuaccu      960

cggcauccac aggagcugcu cgccucagca gauuuccaac ccgugccgag uauugucggc     1020

gugaauaaca augaguucgg auggcugauc ccuaagguca ugcgcauuua ugacacucag     1080

aaagagaugg accgagaagc cagccaggcu gcgcuucaaa agaugcugac cuugcucaug     1140

cugcccccaa cauuuggcga uuuacugaga gaggaauaca ucggggacaa cggagauccu     1200

cagacucuac aggcacaguu ccaagagaug auggccgacu ccauguuugu gauccccgcu     1260

cuccagguug cccacuucca guguucuagg gcaccagugu auuuuuacga guuccagcac     1320

caacccagcu ggcugaaaaa uauucggccu ccacauauga aggccgauca cggugacgaa     1380

cuuccguuug uauuccguuc auuuuucggc gggaacuaca uaaaauuuac cgaggaagag     1440

gaacaguuga gucgcaagau gaugaaguau ugggcuaauu ucgccagaaa cggaaacccc     1500

aauggcgagg gucugccuca uuggccacuc uuugaucagg aggaacagua ccugcaacuu     1560

aaccugcagc ccgcagucgg gagggcguug aaagcucacc ggcuccaguu cuggaagaaa     1620

gcccugccuc agaagaucca agaguuagaa gaaccagagg aacgacauac agagcuguga     1680


<210>  1971
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       iCE__Homo_sapiens__BAA23606

<400>  1971
augagacugc acagacugag agccagacug agcgccgugg ccugcggccu gcugcugcug       60

cuggugagag gccagggcca ggacagcgcc agccccauca gaaccaccca caccggccag      120

gugcugggca gccuggugca cgugaagggc gccaacgccg gcgugcagac cuuccugggc      180

auccccuucg ccaagccccc ccugggcccc cugagauucg ccccccccga gccccccgag      240

agcuggagcg gcgugagaga cggcaccacc caccccgcca ugugccugca ggaccugacc      300

gccguggaga gcgaguuccu gagccaguuc aacaugaccu uccccagcga cagcaugagc      360

gaggacugcc uguaccugag caucuacacc cccgcccaca gccacgaggg cagcaaccug      420

cccgugaugg uguggaucca cggcggcgcc cugguguucg gcauggccag ccuguacgac      480

ggcagcaugc uggccgcccu ggagaacgug guggugguga ucauccagua cagacugggc      540

gugcugggcu ucuucagcac cggcgacaag cacgccaccg gcaacugggg cuaccuggac      600

cagguggccg cccugagaug ggugcagcag aacaucgccc acuucggcgg caaccccgac      660

agagugacca ucuucggcga gagcgccggc ggcaccagcg ugagcagccu gguggugagc      720

cccaucagcc agggccuguu ccacggcgcc aucauggaga gcggcguggc ccugcugccc      780

ggccugaucg ccagcagcgc cgacgugauc agcaccgugg uggccaaccu gagcgccugc      840

gaccaggugg acagcgaggc ccuggugggc ugccugagag gcaagagcaa ggaggagauc      900

cuggccauca acaagcccuu caagaugauc cccggcgugg uggacggcgu guuccugccc      960

agacaccccc aggagcugcu ggccagcgcc gacuuccagc ccgugcccag caucgugggc     1020

gugaacaaca acgaguucgg cuggcugauc cccaagguga ugagaaucua cgacacccag     1080

aaggagaugg acagagaggc cagccaggcc gcccugcaga agaugcugac ccugcugaug     1140

cugcccccca ccuucggcga ccugcugaga gaggaguaca ucggcgacaa cggcgacccc     1200

cagacccugc aggcccaguu ccaggagaug auggccgaca gcauguucgu gauccccgcc     1260

cugcaggugg cccacuucca gugcagcaga gcccccgugu acuucuacga guuccagcac     1320

cagcccagcu ggcugaagaa caucagaccc ccccacauga aggccgacca cggcgacgag     1380

cugcccuucg uguucagaag cuucuucggc ggcaacuaca ucaaguucac cgaggaggag     1440

gagcagcuga gcagaaagau gaugaaguac ugggccaacu ucgccagaaa cggcaacccc     1500

aacggcgagg gccugcccca cuggccccug uucgaccagg aggagcagua ccugcagcug     1560

aaccugcagc ccgccguggg cagagcccug aaggcccaca gacugcaguu cuggaagaag     1620

gcccugcccc agaagaucca ggagcuggag gagcccgagg agagacacac cgagcuguga     1680


<210>  1972
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       iCE__Homo_sapiens__BAA23606

<400>  1972
augagacugc accggcuccg cgccagacug agcgcugugg ccugcggccu ucugcuccug       60

cuuguccggg ggcagggaca agacuccgcg ucucccaucc gcaccacaca uacgggccag      120

guucugggga gccucgugca cgugaaggga gcuaacgccg gcguccagac cuuccugggg      180

auuccuuuug ccaaaccgcc ccugggaccu cucagauucg cucccccuga gcccccugaa      240

uccuggucug gcgugcggga uggcacaacc cauccggcca ugugucugca ggaccuuaca      300

gcuguugaga gcgaauuucu gucccaauuc aauaugaccu uucccucuga uagcaugucc      360

gaggacugcc ucuaccugag caucuauacc ccugcccacu cucaugaagg guccaaccuu      420

cccgugaugg ucuggauuca cggaggcgcg cugguguucg ggauggccag ccucuacgau      480

ggaucuaugc uggcugcccu ggagaauguu guggucguga ucauucagua ucgccucggc      540

gugcuggggu uuuucuccac aggagacaag cacgcuacgg gcaacugggg cuaccuugau      600

caggucgccg cgcugagaug gguucagcaa aauaucgccc auuuuggggg aaacccugac      660

cgggugacca ucuucggcga gagcgcuggg ggaacaucug uguccagccu cgucgugucc      720

cccauuucuc agggccuguu ucacggggcc aucauggaaa gcggaguugc ccuucugccg      780

ggccucauug cuuccagcgc cgaugugauc ucuaccgucg uggcuaaucu guccgcgugu      840

gaccagguug auagcgaggc ccuggugggc ugccuccgcg ggaaaucuaa ggaagagauu      900

cuggcuauca acaaaccuuu caagaugauu cccggagucg uggacggcgu cuuucuuccu      960

agacaucccc aggagcugcu cgccagcgcc gauuuccaac ccgugccuuc caucguuggg     1020

gugaauaaca augaauuugg auggcugauc ccgaagguca ugcggauuua ugacacacag     1080

aaagagaugg accgcgaggc uucucaggcc gcgcuucaaa agaugcugac ccuccugaug     1140

cugcccccua cguuuggcga ucuccugaga gaggaauaca ucggggacaa cggcgauccc     1200

cagacacuuc aggcucaguu ccaagagaug auggccgaca gcauguuugu gauuccugcc     1260

cugcagguug cucacuucca guguucccgg gcccccgugu auuuuuacga guuccagcac     1320

caaccgagcu ggcucaaaaa uauccgcccu ccccauauga aggcugauca cggagacgaa     1380

cugccuuuug ucuucagauc uuucuucggc gggaacuaca uuaaauuuac cgaggaagag     1440

gaacagcugu cccggaagau gaugaaguau ugggccaauu ucgcgagaaa cggaaacccc     1500

aauggcgagg ggcuuccuca uuggccccuc uuugaucagg aggaacagua ccugcaacug     1560

aaccuccagc cggccguggg acgcgcucug aaagcccacc ggcuucaguu cuggaagaaa     1620

gcucugccuc agaagaucca agagcucgaa gaacccgaag agagacauac agagcuguga     1680


<210>  1973
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IF2B3__Homo_sapiens__O00425

<400>  1973

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  1974
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IF2B3__Homo_sapiens__AAH65269

<400>  1974
augaacaaac uguauaucgg aaaccucagc gagaacgccg cccccucgga ccuagaaagu       60

aucuucaagg acgccaagau cccggugucg ggacccuucc uggugaagac uggcuacgcg      120

uucguggacu gcccggacga gagcugggcc cucaaggcca ucgaggcgcu uucagguaaa      180

auagaacugc acgggaaacc cauagaaguu gagcacucgg ucccaaaaag gcaaaggauu      240

cggaaacuuc agauacgaaa uaucccgccu cauuuacagu gggaggugcu ggauaguuua      300

cuaguccagu auggaguggu ggagagcugu gagcaaguga acacugacuc ggaaacugca      360

guuguaaaug uaaccuauuc caguaaggac caagcuagac aagcacuaga caaacugaau      420

ggauuucagu uagagaauuu caccuugaaa guagccuaua ucccugauga aauggccgcc      480

cagcaaaacc ccuugcagca gccccgaggu cgccgggggc uugggcagag gggcuccuca      540

aggcaggggu cuccaggauc cguauccaag cagaaaccau gugauuugcc ucugcgccug      600

cugguuccca cccaauuugu uggagccauc auaggaaaag aaggugccac cauucggaac      660

aucaccaaac agacccaguc uaaaaucgau guccaccgua aagaaaaugc gggggcugcu      720

gagaagucga uuacuauccu cucuacuccu gaaggcaccu cugcggcuug uaagucuauu      780

cuggagauua ugcauaagga agcucaagau auaaaauuca cagaagagau ccccuugaag      840

auuuuagcuc auaauaacuu uguuggacgu cuuauuggua aagaaggaag aaaucuuaaa      900

aaaauugagc aagacacaga cacuaaaauc acgauaucuc cauugcagga auugacgcug      960

uauaauccag aacgcacuau uacaguuaaa ggcaauguug agacaugugc caaagcugag     1020

gaggagauca ugaagaaaau cagggagucu uaugaaaaug auauugcuuc uaugaaucuu     1080

caagcacauu uaauuccugg auuaaaucug aacgccuugg gucuguuccc acccacuuca     1140

gggaugccac cucccaccuc agggcccccu ucagccauga cuccucccua cccgcaguuu     1200

gagcaaucag aaacggagac uguucaucug uuuaucccag cucuaucagu cggugccauc     1260

aucggcaagc agggccagca caucaagcag cuuucucgcu uugcuggagc uucaauuaag     1320

auugcuccag cagaagcacc agaugcuaaa gugaggaugg ugauuaucac uggaccacca     1380

gaggcucagu ucaaggcuca gggaagaauu uauggaaaaa uuaaagaaga aaacuuuguu     1440

aguccuaaag aagaggugaa acuugaagcu cauaucagag ugccauccuu ugcugcuggc     1500

agaguuauug gaaaaggagg caaaacggug aaugaacuuc agaauuuguc aagugcagaa     1560

guuguugucc cucgugacca gacaccugau gagaaugacc aagugguugu caaaauaacu     1620

ggucacuucu augcuugcca gguugcccag agaaaaauuc aggaaauucu gacucaggua     1680

aagcagcacc aacaacagaa ggcucugcaa aguggaccac cucagucaag acggaaguaa     1740


<210>  1975
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IF2B3__Homo_sapiens__AAH65269

<400>  1975
augaacaagc uguacaucgg caaccucagc gagaacgccg cccccuccga ccuggagagc       60

aucuucaagg acgcgaagau cccggugucc gggcccuucc uggucaagac cggcuacgcc      120

uucguggacu gccccgacga gagcugggcc cucaaggcca ucgaggcccu guccgggaag      180

aucgagcugc acggcaagcc caucgaggug gagcacagcg ucccgaagcg ccagcggauc      240

cgcaagcucc agauccggaa caucccgccc caccuccagu gggaggugcu ggacucccug      300

cuggugcagu acggggucgu ggagagcugc gagcagguca acaccgacuc cgagacggcg      360

guggugaacg ugaccuacag cuccaaggac caggcccgcc aggcccugga caagcucaac      420

ggcuuccagc uggagaacuu cacccugaag gucgccuaca uccccgacga gauggcggcc      480

cagcagaacc cccuccagca gccccggggc cgccgggggc ugggccagcg cgggagcucc      540

cggcagggca gccccggguc cgugagcaag cagaagcccu gcgaccugcc gcuccgccug      600

cuggugccca cccaguucgu cggcgccauc aucggcaagg agggggccac gauccggaac      660

aucaccaagc agacccaguc caagaucgac gugcaccgca aggagaacgc cggcgcggcc      720

gagaagucca ucaccauccu cagcacgccc gaggggacca gcgccgccug caagagcauc      780

cuggagauca ugcacaagga ggcccaggac aucaaguuca ccgaggagau cccccugaag      840

auccucgcgc acaacaacuu cgugggccgg cugaucggca aggaggggcg caaccugaag      900

aagaucgagc aggacaccga cacgaagauc accaucuccc cgcuccagga gcugacccug      960

uacaaccccg agcggaccau cacggucaag ggcaacgugg agaccugcgc caaggccgag     1020

gaggagauca ugaagaagau ccgcgagagc uacgagaacg acaucgccuc caugaaccuc     1080

caggcccacc ugauccccgg gcugaaccuc aacgcgcugg gccuguuccc gcccaccagc     1140

gggaugcccc cgcccaccuc cggcccgccc agcgccauga cgccgcccua cccccaguuc     1200

gagcaguccg agaccgagac cgugcaccuc uucauccccg cccugagcgu cggcgccauc     1260

aucgggaagc agggccagca caucaagcag cugucccggu ucgccggggc gagcaucaag     1320

aucgcccccg ccgaggcccc cgacgcgaag gugcgcaugg ugaucaucac cggcccgccc     1380

gaggcccagu ucaaggccca ggggcggauc uacggcaaga ucaaggagga gaacuucguc     1440

ucccccaagg aggaggugaa gcucgaggcc cacauccgcg uccccagcuu cgccgcgggc     1500

cgggugaucg ggaagggcgg gaagacggug aacgagcugc agaaccuguc cagcgccgag     1560

gucguggugc cccgcgacca gacccccgac gagaacgacc aggucguggu gaagaucacc     1620

ggccacuucu acgccugcca ggucgcccag cgcaagaucc aggagauccu cacccaggug     1680

aagcagcacc agcagcagaa ggcccugcag uccgggcccc cgcagagccg gcgcaaguga     1740


<210>  1976
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IF2B3__Homo_sapiens__AAH65269

<400>  1976
augaacaagc ucuacaucgg caaccucucc gagaacgccg cccccuccga ccucgagucc       60

aucuucaagg acgccaagau ccccgucucc ggccccuucc ucgucaagac cggcuacgcc      120

uucgucgacu gccccgacga guccugggcc cucaaggcca ucgaggcccu cuccggcaag      180

aucgagcucc acggcaagcc caucgagguc gagcacuccg uccccaagcg ccagcgcauc      240

cgcaagcucc agauccgcaa cauccccccc caccuccagu gggagguccu cgacucccuc      300

cucguccagu acggcgucgu cgaguccugc gagcagguca acaccgacuc cgagaccgcc      360

gucgucaacg ucaccuacuc cuccaaggac caggcccgcc aggcccucga caagcucaac      420

ggcuuccagc ucgagaacuu cacccucaag gucgccuaca uccccgacga gauggccgcc      480

cagcagaacc cccuccagca gccccgcggc cgccgcggcc ucggccagcg cggcuccucc      540

cgccagggcu cccccggcuc cgucuccaag cagaagcccu gcgaccuccc ccuccgccuc      600

cucgucccca cccaguucgu cggcgccauc aucggcaagg agggcgccac cauccgcaac      660

aucaccaagc agacccaguc caagaucgac guccaccgca aggagaacgc cggcgccgcc      720

gagaagucca ucaccauccu cuccaccccc gagggcaccu ccgccgccug caaguccauc      780

cucgagauca ugcacaagga ggcccaggac aucaaguuca ccgaggagau cccccucaag      840

auccucgccc acaacaacuu cgucggccgc cucaucggca aggagggccg caaccucaag      900

aagaucgagc aggacaccga caccaagauc accaucuccc cccuccagga gcucacccuc      960

uacaaccccg agcgcaccau caccgucaag ggcaacgucg agaccugcgc caaggccgag     1020

gaggagauca ugaagaagau ccgcgagucc uacgagaacg acaucgccuc caugaaccuc     1080

caggcccacc ucauccccgg ccucaaccuc aacgcccucg gccucuuccc ccccaccucc     1140

ggcaugcccc cccccaccuc cggccccccc uccgccauga ccccccccua cccccaguuc     1200

gagcaguccg agaccgagac cguccaccuc uucauccccg cccucuccgu cggcgccauc     1260

aucggcaagc agggccagca caucaagcag cucucccgcu ucgccggcgc cuccaucaag     1320

aucgcccccg ccgaggcccc cgacgccaag guccgcaugg ucaucaucac cggccccccc     1380

gaggcccagu ucaaggccca gggccgcauc uacggcaaga ucaaggagga gaacuucguc     1440

ucccccaagg aggaggucaa gcucgaggcc cacauccgcg uccccuccuu cgccgccggc     1500

cgcgucaucg gcaagggcgg caagaccguc aacgagcucc agaaccucuc cuccgccgag     1560

gucgucgucc cccgcgacca gacccccgac gagaacgacc aggucgucgu caagaucacc     1620

ggccacuucu acgccugcca ggucgcccag cgcaagaucc aggagauccu cacccagguc     1680

aagcagcacc agcagcagaa ggcccuccag uccggccccc cccagucccg ccgcaaguga     1740


<210>  1977
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IF2B3__Homo_sapiens__AAH65269

<400>  1977
augaacaagc uguacaucgg caaucucagc gagaacgccg cucccuccga ccuugaaucu       60

auuuucaaag augcaaagau accuguguca gggccauuuc uggucaaaac cggauaugcc      120

uucguugacu gcccggauga gaguugggcg uugaaggcua ucgaagccuu aagcgguaaa      180

auugagcugc acggcaagcc caucgaagug gagcauuccg uaccuaagag acagaggauu      240

cggaaacuac aaauccgcaa uauaccaccc caccuccagu gggaggugcu ggacucucuu      300

cugguccagu acgggguggu ugaaucgugu gaacagguga acacagauuc agagacugca      360

gucgugaaug uaacguauag caguaaggac caagcccgac aggcuuugga uaaacucaac      420

ggauuucagc uggagaauuu cacccugaag guugcauaca ucccugacga gauggccgcu      480

cagcaaaacc cacuccagca gccccguggc agaagggguu uagggcagcg gggauccucu      540

cgccaaggca gcccuggcuc cgugucaaaa cagaagccau gcgaucugcc gcuuagauug      600

cuggucccca cacaguuugu gggggccauu aucggaaagg aaggugcgac uauuaggaau      660

aucaccaaac aaacacagag uaagauagac gugcaucgga aagagaacgc aggcgccgcu      720

gaaaagagca uuaccauccu aucuacuccu gaggggacau ccgccgcaug uaaaucaauu      780

cucgaaauca ugcacaagga ggcucaggau aucaaauuca ccgaggaaau uccacugaag      840

auacuugccc auaauaacuu ugucggacgc cugaucggca aggagggucg aaauuugaaa      900

aagauugaac aggacacgga uacuaaaauc accauaagcc cccuccaaga gcugacauua      960

uauaacccug aaagaacuau uaccguuaag gggaaugugg agacaugcgc gaaagccgag     1020

gaagagauca ugaagaagau cagggaaagu uacgagaacg acauugcauc uaugaaccug     1080

caggcucacc ucaucccagg acuuaaucug aacgccuugg gccuauuucc cccgaccucc     1140

ggcaugccuc ccccaacgag cgggccuccc ucggcuauga cuccacccua uccucaguuc     1200

gaacagucug agacagagac cguacaccug uucauuccag cccucuccgu gggagcaaua     1260

aucgguaaac aaggccagca uauuaagcag cugucacggu uugccggggc uaguaucaaa     1320

aucgcgccgg cagaagcccc cgacgcuaag guccguaugg ugauuauaac uggaccucca     1380

gaggcccagu ucaaagcaca aggccgcauc uacgguaaga uuaaggaaga gaauuuuguu     1440

agccccaaag aggaagugaa acuugaggcc cacaucagag ucccuuccuu cgcugccggg     1500

agggugauug gcaagggagg caagacagua aacgaacugc agaauuuguc uagcgcagag     1560

guuguggucc cacgggauca gacccccgac gaaaacgauc agguggucgu gaaaaucacg     1620

gggcauuucu acgcguguca aguugcucag cgaaagauac aggagauccu cacccaagug     1680

aagcagcacc agcagcaaaa agcccugcag ucaggaccgc cucagagucg cagaaaguga     1740


<210>  1978
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IF2B3__Homo_sapiens__AAH65269

<400>  1978
augaacaagc uguacaucgg caaccugagc gagaacgccg cccccagcga ccuggagagc       60

aucuucaagg acgccaagau ccccgugagc ggccccuucc uggugaagac cggcuacgcc      120

uucguggacu gccccgacga gagcugggcc cugaaggcca ucgaggcccu gagcggcaag      180

aucgagcugc acggcaagcc caucgaggug gagcacagcg ugcccaagag acagagaauc      240

agaaagcugc agaucagaaa cauccccccc caccugcagu gggaggugcu ggacagccug      300

cuggugcagu acggcguggu ggagagcugc gagcagguga acaccgacag cgagaccgcc      360

guggugaacg ugaccuacag cagcaaggac caggccagac aggcccugga caagcugaac      420

ggcuuccagc uggagaacuu cacccugaag guggccuaca uccccgacga gauggccgcc      480

cagcagaacc cccugcagca gcccagaggc agaagaggcc ugggccagag aggcagcagc      540

agacagggca gccccggcag cgugagcaag cagaagcccu gcgaccugcc ccugagacug      600

cuggugccca cccaguucgu gggcgccauc aucggcaagg agggcgccac caucagaaac      660

aucaccaagc agacccagag caagaucgac gugcacagaa aggagaacgc cggcgccgcc      720

gagaagagca ucaccauccu gagcaccccc gagggcacca gcgccgccug caagagcauc      780

cuggagauca ugcacaagga ggcccaggac aucaaguuca ccgaggagau cccccugaag      840

auccuggccc acaacaacuu cgugggcaga cugaucggca aggagggcag aaaccugaag      900

aagaucgagc aggacaccga caccaagauc accaucagcc cccugcagga gcugacccug      960

uacaaccccg agagaaccau caccgugaag ggcaacgugg agaccugcgc caaggccgag     1020

gaggagauca ugaagaagau cagagagagc uacgagaacg acaucgccag caugaaccug     1080

caggcccacc ugauccccgg ccugaaccug aacgcccugg gccuguuccc ccccaccagc     1140

ggcaugcccc cccccaccag cggccccccc agcgccauga ccccccccua cccccaguuc     1200

gagcagagcg agaccgagac cgugcaccug uucauccccg cccugagcgu gggcgccauc     1260

aucggcaagc agggccagca caucaagcag cugagcagau ucgccggcgc cagcaucaag     1320

aucgcccccg ccgaggcccc cgacgccaag gugagaaugg ugaucaucac cggccccccc     1380

gaggcccagu ucaaggccca gggcagaauc uacggcaaga ucaaggagga gaacuucgug     1440

agccccaagg aggaggugaa gcuggaggcc cacaucagag ugcccagcuu cgccgccggc     1500

agagugaucg gcaagggcgg caagaccgug aacgagcugc agaaccugag cagcgccgag     1560

gugguggugc ccagagacca gacccccgac gagaacgacc aggugguggu gaagaucacc     1620

ggccacuucu acgccugcca gguggcccag agaaagaucc aggagauccu gacccaggug     1680

aagcagcacc agcagcagaa ggcccugcag agcggccccc cccagagcag aagaaaguga     1740


<210>  1979
<211>  1740
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IF2B3__Homo_sapiens__AAH65269

<400>  1979
augaacaagc uguacaucgg caaucucagc gagaacgccg cucccuccga ccuggaaucu       60

auuuucaaag augccaagau cccugugagc gggccguuuc uugucaaaac cggauaugcg      120

uucguugacu gccccgauga guccugggcu cugaaggcca uugaagcccu cucuggcaaa      180

aucgagcugc acgggaagcc uauugaagug gagcauagcg ugcccaagag acagcggauc      240

cgcaaacuuc aaaucagaaa uauuccuccc caccuucagu gggagguccu cgacucccug      300

cuggugcagu acggaguugu ggaaucuugu gagcagguca acacagauag cgaaacggcu      360

gugguuaaug ugaccuauuc cagcaaggac caagcccggc aggcucucga uaaacugaac      420

ggcuuucagc uugagaauuu cacacugaag gucgccuaca ucccugacga gauggcggcc      480

cagcaaaacc cgcuccagca gccccgcggg agacggggac ugggccagcg cgggucuucc      540

agacaaggca gcccuggauc uguguccaaa cagaagcccu gcgaucuucc ucugcggcuc      600

cuggugccca cccaguuugu cggcgcuauu aucgggaagg aaggagccac aauucgcaau      660

aucaccaaac aaacacagag caagauugac guucauagaa aagagaacgc uggcgccgcg      720

gaaaagucua ucaccauccu guccacgccg gaggggacca gcgccgcuug uaaauccauu      780

cucgaaauca ugcacaagga ggcccaggau auuaaauuca cagaggaaau cccucugaag      840

auucuugcuc auaauaacuu ugugggacgg cugaucggca aggagggccg caaucucaaa      900

aagaucgaac aggacaccga uacaaaaauu accaucucuc cccugcaaga gcuuacgcug      960

uauaacccug aaagaacaau uaccgugaag gggaaugucg agacaugcgc caaagccgag     1020

gaagagauca ugaagaagau ucgggaaagc uacgagaacg acaucgcuuc caugaaccuc     1080

caggcgcacc ugauccccgg acugaaucuc aacgcccugg gccuuuuucc cccuaccagc     1140

gggaugccgc ccccuaccuc uggacccccu uccgcuauga cacccccgua uccucaguuc     1200

gaacagagcg agacggagac cgugcaccug uucauucccg cccucucugu uggcgccauc     1260

auugggaaac aaggacagca uaucaagcag cugagccgcu uugcuggcgc cuccauuaaa     1320

aucgcgccug cugaagcccc cgacgccaag gugagaaugg ucauuaucac aggcccuccc     1380

gaggcucagu ucaaagccca agggcggauc uacggaaaga uuaaggaaga gaauuuugug     1440

ucuccgaaag aggaaguuaa gcuggaggcu cacaucagag ugccuagcuu cgccgcgggc     1500

cgcgucauug ggaaaggagg caagaccgug aacgaacugc agaaucucuc cagcgccgag     1560

gucgugguuc cccgggauca gacacccgac gaaaacgauc agguggucgu gaaaaucacc     1620

gggcauuucu acgcuuguca aguugcccag agaaagauuc aggagauccu gacgcaagug     1680

aagcagcacc agcagcaaaa agcucugcag ucuggcccuc cgcagucccg ccggaaguga     1740


<210>  1980
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-13Ra2__Homo_sapiens__Q14627

<400>  1980

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  1981
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-13Ra2__Homo_sapiens__AAB17170

<400>  1981
auggcuuucg uuugcuuggc uaucggaugc uuauauaccu uucugauaag cacaacauuu       60

ggcuguacuu caucuucaga caccgagaua aaaguuaacc cuccucagga uuuugagaua      120

guggaucccg gauacuuagg uuaucucuau uugcaauggc aacccccacu gucucuggau      180

cauuuuaagg aaugcacagu ggaauaugaa cuaaaauacc gaaacauugg uagugaaaca      240

uggaagacca ucauuacuaa gaaucuacau uacaaagaug gguuugaucu uaacaagggc      300

auugaagcga agauacacac gcuuuuacca uggcaaugca caaauggauc agaaguucaa      360

aguuccuggg cagaaacuac uuauuggaua ucaccacaag gaauuccaga aacuaaaguu      420

caggauaugg auugcguaua uuacaauugg caauauuuac ucuguucuug gaaaccuggc      480

auagguguac uucuugauac caauuacaac uuguuuuacu gguaugaggg cuuggaucau      540

gcauuacagu guguugauua caucaaggcu gauggacaaa auauaggaug cagauuuccc      600

uauuuggagg caucagacua uaaagauuuc uauauuugug uuaauggauc aucagagaac      660

aagccuauca gauccaguua uuucacuuuu cagcuucaaa auauaguuaa accuuugccg      720

ccagucuauc uuacuuuuac ucgggagagu ucaugugaaa uuaagcugaa auggagcaua      780

ccuuugggac cuauuccagc aagguguuuu gauuaugaaa uugagaucag agaagaugau      840

acuaccuugg ugacugcuac aguugaaaau gaaacauaca ccuugaaaac aacaaaugaa      900

acccgacaau uaugcuuugu aguaagaagc aaagugaaua uuuauugcuc agaugacgga      960

auuuggagug aguggaguga uaaacaaugc ugggaaggug aagaccuauc gaagaaaacu     1020

uugcuacguu ucuggcuacc auuugguuuc aucuuaauau uaguuauauu uguaaccggu     1080

cugcuuuugc guaagccaaa caccuaccca aaaaugauuc cagaauuuuu cugugauaca     1140

uga                                                                   1143


<210>  1982
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-13Ra2__Homo_sapiens__AAB17170

<400>  1982
auggccuucg ugugccuggc caucggcugc cucuacaccu uccugaucag caccacguuc       60

gggugcaccu ccagcuccga caccgagauc aaggucaacc cgccccagga cuucgagauc      120

guggaccccg gcuaccuggg guaccucuac cugcaguggc agccgccccu gagccucgac      180

cacuucaagg agugcaccgu ggaguacgag cugaaguacc gcaacaucgg cuccgagacg      240

uggaagacca ucaucaccaa gaaccugcac uacaaggacg gguucgaccu caacaagggc      300

aucgaggcga agauccacac ccugcugccc uggcagugca cgaacggcag cgagguccag      360

uccagcuggg ccgagaccac cuacuggauc agcccccagg ggauccccga gaccaaggug      420

caggacaugg acugcgugua cuacaacugg caguaccucc ugugcuccug gaagcccggc      480

aucggggucc ugcucgacac gaacuacaac cuguucuacu gguacgaggg ccuggaccac      540

gcccuccagu gcguggacua caucaaggcc gacgggcaga acaucggcug ccgguucccg      600

uaccuggagg ccuccgacua caaggacuuc uacaucugcg ugaacggcag cuccgagaac      660

aagcccaucc gcagcuccua cuucaccuuc cagcugcaga acaucgucaa gccccugccc      720

ccgguguacc ucaccuucac ccgggagagc uccugcgaga ucaagcugaa guggagcauc      780

ccccucgggc ccauccccgc gcgcugcuuc gacuacgaga ucgagauccg ggaggacgac      840

acgacccugg ugaccgccac cgucgagaac gagacguaca cccugaagac caccaacgag      900

acgcgccagc ucugcuucgu ggugcggucc aaggucaaca ucuacugcag cgacgacggc      960

aucuggagcg agugguccga caagcagugc ugggaggggg aggaccugag caagaagacc     1020

cugcuccgcu ucuggcugcc guucggcuuc auccugaucc ucgugaucuu cgugaccggc     1080

cugcugcucc ggaagcccaa caccuacccc aagaugaucc ccgaguucuu cugcgacacg     1140

uga                                                                   1143


<210>  1983
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-13Ra2__Homo_sapiens__AAB17170

<400>  1983
auggccuucg ucugccucgc caucggcugc cucuacaccu uccucaucuc caccaccuuc       60

ggcugcaccu ccuccuccga caccgagauc aaggucaacc ccccccagga cuucgagauc      120

gucgaccccg gcuaccucgg cuaccucuac cuccaguggc agcccccccu cucccucgac      180

cacuucaagg agugcaccgu cgaguacgag cucaaguacc gcaacaucgg cuccgagacc      240

uggaagacca ucaucaccaa gaaccuccac uacaaggacg gcuucgaccu caacaagggc      300

aucgaggcca agauccacac ccuccucccc uggcagugca ccaacggcuc cgagguccag      360

uccuccuggg ccgagaccac cuacuggauc uccccccagg gcauccccga gaccaagguc      420

caggacaugg acugcgucua cuacaacugg caguaccucc ucugcuccug gaagcccggc      480

aucggcgucc uccucgacac caacuacaac cucuucuacu gguacgaggg ccucgaccac      540

gcccuccagu gcgucgacua caucaaggcc gacggccaga acaucggcug ccgcuucccc      600

uaccucgagg ccuccgacua caaggacuuc uacaucugcg ucaacggcuc cuccgagaac      660

aagcccaucc gcuccuccua cuucaccuuc cagcuccaga acaucgucaa gccccucccc      720

cccgucuacc ucaccuucac ccgcgagucc uccugcgaga ucaagcucaa gugguccauc      780

ccccucggcc ccauccccgc ccgcugcuuc gacuacgaga ucgagauccg cgaggacgac      840

accacccucg ucaccgccac cgucgagaac gagaccuaca cccucaagac caccaacgag      900

acccgccagc ucugcuucgu cguccgcucc aaggucaaca ucuacugcuc cgacgacggc      960

aucugguccg agugguccga caagcagugc ugggagggcg aggaccucuc caagaagacc     1020

cuccuccgcu ucuggcuccc cuucggcuuc auccucaucc ucgucaucuu cgucaccggc     1080

cuccuccucc gcaagcccaa caccuacccc aagaugaucc ccgaguucuu cugcgacacc     1140

uga                                                                   1143


<210>  1984
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-13Ra2__Homo_sapiens__AAB17170

<400>  1984
auggccuucg ugugccuggc uaucggcugu cucuacaccu uucuuauuag cacaacuuuc       60

gggugcacgu ccucuucaga caccgagaua aaggucaauc ccccucagga uuuugaaauc      120

guugacccag gauaucuggg uuacuuguau uuacaauggc agccgccccu gagucuagau      180

cacuucaaag aguguacagu ggaauacgag cucaaguaua gaaacauugg cagcgaaacu      240

uggaaaacca ucauuacaaa gaaccugcau uacaaagacg gguuugaucu uaauaaggga      300

aucgaggcaa agauacacac ccuguugccu uggcagugca cuaacggcuc cgagguacag      360

ucuucguggg ccgaaacaac cuauuggauc ucaccacaag guauucccga gacgaaagug      420

caggacaugg auugugucua cuacaauugg caguaucucc ugugcagcug gaagccuggg      480

aucggagugc ugcucgacac uaacuacaau uuauucuauu gguacgaagg ccuggaucau      540

gcgcuucagu guguugacua uauuaaagcu gauggccaaa acaucgggug cagguuucca      600

uacuuggagg ccagugacua uaaggauuuc uacauaugug ugaauggauc cucugagaac      660

aaacccauuc ggagcuccua cuuuaccuuc cagcugcaga auaucgucaa gccucuacca      720

ccgguguauc ucacauuuac ucgcgaauca aguugcgaga uuaagcugaa auggagcauc      780

ccccuugguc cuaucccagc acgauguuuc gacuacgaaa uugagauacg ugaagacgau      840

accacacugg uaaccgccac gguugagaac gagacuuaua cauugaagac cacuaaugaa      900

acaagacagc ucugcuuugu ggucaggucu aaagugaaca ucuacugcuc cgacgauggc      960

auuuggucag aguggagcga caagcaaugu ugggaagggg aggaucugag uaaaaagacc     1020

uuacugcggu ucuggcuccc cuucggauuu auccuuauac uggugauuuu cgucacgggc     1080

uugcuacugc gcaaaccuaa uaccuaucca aagaugaucc ccgaauuuuu cugcgacaca     1140

uga                                                                   1143


<210>  1985
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-13Ra2__Homo_sapiens__AAB17170

<400>  1985
auggccuucg ugugccuggc caucggcugc cuguacaccu uccugaucag caccaccuuc       60

ggcugcacca gcagcagcga caccgagauc aaggugaacc ccccccagga cuucgagauc      120

guggaccccg gcuaccuggg cuaccuguac cugcaguggc agcccccccu gagccuggac      180

cacuucaagg agugcaccgu ggaguacgag cugaaguaca gaaacaucgg cagcgagacc      240

uggaagacca ucaucaccaa gaaccugcac uacaaggacg gcuucgaccu gaacaagggc      300

aucgaggcca agauccacac ccugcugccc uggcagugca ccaacggcag cgaggugcag      360

agcagcuggg ccgagaccac cuacuggauc agcccccagg gcauccccga gaccaaggug      420

caggacaugg acugcgugua cuacaacugg caguaccugc ugugcagcug gaagcccggc      480

aucggcgugc ugcuggacac caacuacaac cuguucuacu gguacgaggg ccuggaccac      540

gcccugcagu gcguggacua caucaaggcc gacggccaga acaucggcug cagauucccc      600

uaccuggagg ccagcgacua caaggacuuc uacaucugcg ugaacggcag cagcgagaac      660

aagcccauca gaagcagcua cuucaccuuc cagcugcaga acaucgugaa gccccugccc      720

cccguguacc ugaccuucac cagagagagc agcugcgaga ucaagcugaa guggagcauc      780

ccccugggcc ccauccccgc cagaugcuuc gacuacgaga ucgagaucag agaggacgac      840

accacccugg ugaccgccac cguggagaac gagaccuaca cccugaagac caccaacgag      900

accagacagc ugugcuucgu ggugagaagc aaggugaaca ucuacugcag cgacgacggc      960

aucuggagcg aguggagcga caagcagugc ugggagggcg aggaccugag caagaagacc     1020

cugcugagau ucuggcugcc cuucggcuuc auccugaucc uggugaucuu cgugaccggc     1080

cugcugcuga gaaagcccaa caccuacccc aagaugaucc ccgaguucuu cugcgacacc     1140

uga                                                                   1143


<210>  1986
<211>  1143
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-13Ra2__Homo_sapiens__AAB17170

<400>  1986
auggccuucg ugugccuggc uaucggcugu cucuacaccu uucugauuag cacaacguuc       60

gggugcaccu ccucuagcga cacagagauc aaggucaauc ccccucagga uuuugaaauu      120

guugacccgg gauaucuugg cuaccuguau cuccaauggc agcccccucu gucccuugau      180

cacuucaaag aguguaccgu ggaauacgag cugaaguaua gaaacaucgg gucugaaaca      240

uggaaaacca uuaucacaaa gaaccuccau uacaaagacg gauuugaucu gaauaagggc      300

aucgaggcca agauucacac ccugcucccc uggcagugca cgaacgggag cgaggugcag      360

uccucuuggg cggaaaccac auauuggauc agcccucaag gcauucccga gaccaaaguc      420

caggacaugg auugugugua cuacaauugg caguaucugc uuugcuccug gaagccugga      480

aucggcguuc ugcucgacac aaacuacaau cuguucuauu gguacgaagg gcuugaucau      540

gcucugcagu guguggacua uauuaaagcc gauggacaaa acaucggcug ccgguuuccg      600

uaccucgagg ccagcgacua uaaggauuuc uacauuugug ucaauggguc uuccgagaac      660

aaacccaucc gcagcucuua cuuuaccuuc cagcugcaga auaucgugaa gccucugccc      720

ccuguuuauc ucacguuuac aagagaaucc agcugcgaga uuaagcugaa auggucuauc      780

ccccuuggac cgauuccugc ucgguguuuc gacuacgaaa ucgagauucg cgaagacgau      840

accacacugg ugaccgccac cgucgagaac gagacauaua cgcucaagac cacaaaugaa      900

accagacagc ugugcuuugu ggugcggucc aaagucaaca ucuacugcag cgacgauggc      960

aucugguccg aguggucuga caagcaaugu ugggaagggg aggaucuuag caaaaagaca     1020

cugcuccgcu ucuggcugcc cuucggauuu auucugaucc ucguuauuuu cgugaccggc     1080

cugcuucuga gaaaaccuaa uacguauccc aagaugaucc ccgaauuuuu cugcgacaca     1140

uga                                                                   1143


<210>  1987
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL2-RA__Homo_sapiens__P01589

<400>  1987

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         






<210>  1988
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL2-RA__Homo_sapiens__AAA67527

<400>  1988
auggauucau accugcugau guggggacug cucacguuca ucauggugcc uggcugccag       60

gcagagcucu gugacgauga cccgccagag aucccacacg ccacauucaa agccauggcc      120

uacaaggaag gaaccauguu gaacugugaa ugcaagagag guuuccgcag aauaaaaagc      180

gggucacucu auaugcucug uacaggaaac ucuagccacu cguccuggga caaccaaugu      240

caaugcacaa gcucugccac ucggaacaca acgaaacaag ugacaccuca accugaagaa      300

cagaaagaaa ggaaaaccac agaaaugcaa aguccaaugc agccagugga ccaagcgagc      360

cuuccagguc acugcaggga accuccacca ugggaaaaug aagccacaga gagaauuuau      420

cauuucgugg uggggcagau gguuuauuau cagugcgucc agggauacag ggcucuacac      480

agagguccug cugagagcgu cugcaaaaug acccacggga agacaaggug gacccagccc      540

cagcucauau gcacagguga aauggagacc agucaguuuc caggugaaga gaagccucag      600

gcaagccccg aaggccgucc ugagagugag acuuccugcc ucgucacaac aacagauuuu      660

caaauacaga cagaaauggc ugcaaccaug gagacgucca uauuuacaac agaguaccag      720

guagcagugg ccggcugugu uuuccugcug aucagcgucc uccuccugag ugggcucacc      780

uggcagcgga gacagaggaa gaguagaaga acaaucuag                             819


<210>  1989
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL2-RA__Homo_sapiens__AAA67527

<400>  1989
auggacagcu accugcucau guggggccug cugaccuuca ucauggugcc cgggugccag       60

gccgagcucu gcgacgacga cccgcccgag aucccccacg ccaccuucaa ggcgauggcc      120

uacaaggagg gcacgaugcu gaacugcgag ugcaagcgcg gguuccggcg caucaagucc      180

ggcagccugu acaugcucug caccgggaac uccagccacu ccagcuggga caaccagugc      240

cagugcaccu ccagcgccac ccggaacacg accaagcagg ucacgcccca gccggaggag      300

cagaaggagc gcaagaccac cgagaugcag ucccccaugc agcccgugga ccaggccagc      360

cugcccggcc acugccggga gccgccgccc ugggagaacg aggccaccga gcgcaucuac      420

cacuucgugg ucggccagau gguguacuac cagugcgugc agggguaccg ggcgcugcac      480

cgcggccccg ccgaguccgu cugcaagaug acccacggga agacccggug gacgcagccc      540

cagcucaucu gcaccggcga gauggagacc agccaguucc ccggggagga gaagccccag      600

gccucccccg agggccgccc ggagagcgag accuccugcc uggugacgac caccgacuuc      660

cagauccaga ccgagauggc cgcgacgaug gagaccagca ucuucaccac cgaguaccag      720

guggccgucg ccggcugcgu guuccugcuc aucuccgugc ugcugcucag cgggcugacg      780

uggcagcggc gccagcggaa gucccgccgg accaucuga                             819


<210>  1990
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL2-RA__Homo_sapiens__AAA67527

<400>  1990
auggacuccu accuccucau guggggccuc cucaccuuca ucaugguccc cggcugccag       60

gccgagcucu gcgacgacga cccccccgag aucccccacg ccaccuucaa ggccauggcc      120

uacaaggagg gcaccaugcu caacugcgag ugcaagcgcg gcuuccgccg caucaagucc      180

ggcucccucu acaugcucug caccggcaac uccucccacu ccuccuggga caaccagugc      240

cagugcaccu ccuccgccac ccgcaacacc accaagcagg ucacccccca gcccgaggag      300

cagaaggagc gcaagaccac cgagaugcag ucccccaugc agcccgucga ccaggccucc      360

cuccccggcc acugccgcga gccccccccc ugggagaacg aggccaccga gcgcaucuac      420

cacuucgucg ucggccagau ggucuacuac cagugcgucc agggcuaccg cgcccuccac      480

cgcggccccg ccgaguccgu cugcaagaug acccacggca agacccgcug gacccagccc      540

cagcucaucu gcaccggcga gauggagacc ucccaguucc ccggcgagga gaagccccag      600

gccucccccg agggccgccc cgaguccgag accuccugcc ucgucaccac caccgacuuc      660

cagauccaga ccgagauggc cgccaccaug gagaccucca ucuucaccac cgaguaccag      720

gucgccgucg ccggcugcgu cuuccuccuc aucuccgucc uccuccucuc cggccucacc      780

uggcagcgcc gccagcgcaa gucccgccgc accaucuga                             819


<210>  1991
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL2-RA__Homo_sapiens__AAA67527

<400>  1991
auggacagcu accugcucau guggggccuu cugaccuuca ucauggugcc cgggugccag       60

gccgaguugu gugaugacga uccuccagaa auuccgcacg cuacauuuaa ggcaauggcc      120

uauaaagagg gaacuauguu aaacugcgaa uguaagagag guuucaggcg gauaaaaucc      180

ggcucucugu acaugcuaug cacgggaaau ucaagucaua gcuccuggga caaccaaugu      240

cagugcaccu cuucggcgac acgcaauacu accaagcagg ucacacccca gccugaggaa      300

caaaaagagc gaaagaccac ugagaugcag ucaccaaugc agcccguuga ucaggcuagc      360

cucccugggc acugucguga accacccccu ugggagaacg aagccacaga gagaaucuau      420

cauuuugugg uaggccaaau gguguacuau cagugcgucc aggguuacag ggcacugcac      480

cgggggccag ccgagagugu guguaagaug acccauggaa aaacgcgcug gacucagccg      540

caacuuauuu gcaccggcga aauggagaca ucccaguucc ccggcgaaga gaagccucag      600

gcuucuccag aagggagacc cgagagcgag acuuccuguc ugguuaccac aaccgacuuu      660

caaauccaga cggaaauggc agccacuaug gagacaucaa uuuucaccac ugaauaucag      720

guggcugucg ccggaugcgu guuuuugcuc aucaguguac ugcugcucag cgguuuaaca      780

uggcagaggc ggcaacgcaa aucucgaaga accauauga                             819


<210>  1992
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL2-RA__Homo_sapiens__AAA67527

<400>  1992
auggacagcu accugcugau guggggccug cugaccuuca ucauggugcc cggcugccag       60

gccgagcugu gcgacgacga cccccccgag aucccccacg ccaccuucaa ggccauggcc      120

uacaaggagg gcaccaugcu gaacugcgag ugcaagagag gcuucagaag aaucaagagc      180

ggcagccugu acaugcugug caccggcaac agcagccaca gcagcuggga caaccagugc      240

cagugcacca gcagcgccac cagaaacacc accaagcagg ugacccccca gcccgaggag      300

cagaaggaga gaaagaccac cgagaugcag agccccaugc agcccgugga ccaggccagc      360

cugcccggcc acugcagaga gccccccccc ugggagaacg aggccaccga gagaaucuac      420

cacuucgugg ugggccagau gguguacuac cagugcgugc agggcuacag agcccugcac      480

agaggccccg ccgagagcgu gugcaagaug acccacggca agaccagaug gacccagccc      540

cagcugaucu gcaccggcga gauggagacc agccaguucc ccggcgagga gaagccccag      600

gccagccccg agggcagacc cgagagcgag accagcugcc uggugaccac caccgacuuc      660

cagauccaga ccgagauggc cgccaccaug gagaccagca ucuucaccac cgaguaccag      720

guggccgugg ccggcugcgu guuccugcug aucagcgugc ugcugcugag cggccugacc      780

uggcagagaa gacagagaaa gagcagaaga accaucuga                             819


<210>  1993
<211>  819
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL2-RA__Homo_sapiens__AAA67527

<400>  1993
auggacagcu accugcucau guggggccug cuuaccuuca ucauggugcc cgggugccag       60

gccgagcugu gugaugacga uccuccggaa auuccccacg cuacauuuaa ggccauggcg      120

uauaaagagg gaacgaugcu caacugcgaa uguaagagag gcuuccggcg caucaaaucc      180

gggucucugu acaugcuuug caccggaaau agcucccauu cuagcuggga caaccaaugu      240

cagugcacau ccucugcuac cagaaauaca accaagcagg ucacaccuca gcccgaggaa      300

caaaaagagc ggaagaccac ggagaugcag agcccuaugc agcccguuga ucaggccucc      360

cugccuggcc acugucgcga accgcccccu ugggagaacg aagccaccga gagaauuuau      420

cauuuugugg uggggcaaau ggucuacuau cagugcgugc agggauaccg ggcucuccac      480

cgcggccccg ccgagagcgu uuguaagaug acacauggca aaaccagaug gacacagccu      540

caacugaucu gcaccgggga aauggagacg ucucaguucc ccggagaaga gaagccgcag      600

gcuuccccug aaggccggcc cgagagcgag acaucuuguc uggugaccac aaccgacuuu      660

caaauucaga ccgaaauggc cgcgacaaug gagacgucca ucuucaccac agaauaucag      720

gucgccgugg cugggugcgu uuuucuccug aucagcgugc uucugcucuc uggacugacc      780

uggcagcgca gacaacggaa aucccgcaga acaauuuga                             819


<210>  1994
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL2-RB__Homo_sapiens__P14784

<400>  1994

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  1995
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL2-RB__Homo_sapiens__AAA59143

<400>  1995
auggcggccc cugcucuguc cuggcgucug ccccuccuca uccuccuccu gccccuggcu       60

accucuuggg caucugcagc ggugaauggc acuucccagu ucacaugcuu cuacaacucg      120

agagccaaca ucuccugugu cuggagccaa gauggggcuc ugcaggacac uuccugccaa      180

guccaugccu ggccggacag acggcggugg aaccaaaccu gugagcugcu ccccgugagu      240

caagcauccu gggccugcaa ccugauccuc ggagccccag auucucagaa acugaccaca      300

guugacaucg ucacccugag ggugcugugc cgugaggggg ugcgauggag ggugauggcc      360

auccaggacu ucaagcccuu ugagaaccuu cgccugaugg cccccaucuc ccuccaaguu      420

guccacgugg agacccacag augcaacaua agcugggaaa ucucccaagc cucccacuac      480

uuugaaagac accuggaguu cgaggcccgg acgcuguccc caggccacac cugggaggag      540

gccccccugc ugacucucaa gcagaagcag gaauggaucu gccuggagac gcucacccca      600

gacacccagu augaguuuca ggugcggguc aagccucugc aaggcgaguu cacgaccugg      660

agccccugga gccagccccu ggccuucagg acaaagccug cagcccuugg gaaggacacc      720

auuccguggc ucggccaccu ccucgugggc cucagcgggg cuuuuggcuu caucaucuua      780

guguacuugc ugaucaacug caggaacacc gggccauggc ugaagaaggu ccugaagugu      840

aacaccccag accccucgaa guucuuuucc cagcugagcu cagagcaugg aggagacguc      900

cagaaguggc ucucuucgcc cuuccccuca ucguccuuca gcccuggcgg ccuggcaccu      960

gagaucucgc cacuagaagu gcuggagagg gacaagguga cgcagcugcu ccugcagcag     1020

gacaaggugc cugagcccgc auccuuaagc agcaaccacu cgcugaccag cugcuucacc     1080

aaccaggguu acuucuucuu ccaccucccg gaugccuugg agauagaggc cugccaggug     1140

uacuuuacuu acgaccccua cucagaggaa gacccugaug aggguguggc cggggcaccc     1200

acagggucuu ccccccaacc ccugcagccu cugucagggg aggacgacgc cuacugcacc     1260

uuccccucca gggaugaccu gcugcucuuc ucccccaguc uccucggugg ccccagcccc     1320

ccaagcacug ccccuggggg caguggggcc ggugaagaga ggaugccccc uucuuugcaa     1380

gaaagagucc ccagagacug ggacccccag ccccuggggc cucccacccc aggaguccca     1440

gaccuggugg auuuucagcc acccccugag cuggugcugc gagaggcugg ggaggagguc     1500

ccugacgcug gccccaggga gggagucagu uuccccuggu ccaggccucc ugggcagggg     1560

gaguucaggg cccuuaaugc ucgccugccc cugaacacug augccuacuu gucccuccaa     1620

gaacuccagg gucaggaccc aacucacuug guguag                               1656


<210>  1996
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL2-RB__Homo_sapiens__AAA59143

<400>  1996
auggccgccc ccgcgcugag cuggcgccuc ccgcugcuga uccuccugcu gccccucgcc       60

accuccuggg ccagcgccgc cgugaacggc accucccagu ucacgugcuu cuacaacagc      120

cgggcgaaca ucuccugcgu cuggagccag gacggggccc ugcaggacac cuccugccag      180

gugcacgccu ggcccgaccg ccggcgcugg aaccagaccu gcgagcugcu ccccgugagc      240

caggccuccu gggcgugcaa ccugauccug ggcgccccgg acagccagaa gcucaccacg      300

gucgacaucg ugacccugcg ggugcugugc cgcgaggggg uccgguggcg cgugauggcc      360

auccaggacu ucaagcccuu cgagaaccuc cggcugaugg cccccaucuc ccuccaggug      420

guccacgugg agacccaccg cugcaacauc agcugggaga ucucccaggc cagccacuac      480

uucgagcggc accuggaguu cgaggcgcgc acccuguccc ccggccacac gugggaggag      540

gccccgcugc ucacccugaa gcagaagcag gaguggaucu gccuggagac ccucaccccc      600

gacacgcagu acgaguucca ggugcggguc aagccccugc agggggaguu caccaccugg      660

agccccuggu cccagccgcu ggccuuccgc accaagcccg ccgcccucgg caaggacacg      720

auccccuggc ugggccaccu ccuggugggg cugagcggcg cguucggguu caucauccug      780

guguaccucc ugaucaacug ccggaacacc ggccccuggc ugaagaaggu ccucaagugc      840

aacaccccgg accccuccaa guucuucagc cagcugagcu ccgagcacgg gggcgacgug      900

cagaaguggc ugagcucccc cuuccccagc uccagcuucu ccccgggcgg gcucgccccc      960

gagaucagcc cccuggaggu gcuggagcgc gacaagguca cccagcuccu gcugcagcag     1020

gacaaggugc ccgagccggc cucccucagc uccaaccaca gccugacguc cugcuucacc     1080

aaccagggcu acuucuucuu ccaccucccc gacgcccugg agaucgaggc cugccaggug     1140

uacuucaccu acgaccccua cagcgaggag gaccccgacg agggggucgc gggcgccccg     1200

accggcucca gcccccagcc ccugcagccg cuguccgggg aggacgacgc cuacugcacg     1260

uuccccagcc gggacgaccu gcuccuguuc ucccccagcc ugcucggcgg gcccagcccg     1320

cccuccaccg cccccggcgg gagcggcgcc ggcgaggagc gcaugccccc gucccugcag     1380

gagcgggugc cccgcgacug ggacccccag ccccuggggc cgcccacccc cggcgugccc     1440

gaccucgucg acuuccagcc gccgcccgag cuggugcugc gggaggcggg ggaggagguc     1500

cccgacgccg gcccccgcga gggggugagc uuccccuggu cccgcccgcc cggccagggc     1560

gaguuccggg cccucaacgc ccgccugccc cugaacaccg acgcguaccu cagccugcag     1620

gagcugcagg ggcaggaccc cacgcaccuc guguga                               1656


<210>  1997
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL2-RB__Homo_sapiens__AAA59143

<400>  1997
auggccgccc ccgcccucuc cuggcgccuc ccccuccuca uccuccuccu cccccucgcc       60

accuccuggg ccuccgccgc cgucaacggc accucccagu ucaccugcuu cuacaacucc      120

cgcgccaaca ucuccugcgu cuggucccag gacggcgccc uccaggacac cuccugccag      180

guccacgccu ggcccgaccg ccgccgcugg aaccagaccu gcgagcuccu ccccgucucc      240

caggccuccu gggccugcaa ccucauccuc ggcgcccccg acucccagaa gcucaccacc      300

gucgacaucg ucacccuccg cguccucugc cgcgagggcg uccgcuggcg cgucauggcc      360

auccaggacu ucaagcccuu cgagaaccuc cgccucaugg cccccaucuc ccuccagguc      420

guccacgucg agacccaccg cugcaacauc uccugggaga ucucccaggc cucccacuac      480

uucgagcgcc accucgaguu cgaggcccgc acccucuccc ccggccacac cugggaggag      540

gccccccucc ucacccucaa gcagaagcag gaguggaucu gccucgagac ccucaccccc      600

gacacccagu acgaguucca gguccgcguc aagccccucc agggcgaguu caccaccugg      660

ucccccuggu cccagccccu cgccuuccgc accaagcccg ccgcccucgg caaggacacc      720

auccccuggc ucggccaccu ccucgucggc cucuccggcg ccuucggcuu caucauccuc      780

gucuaccucc ucaucaacug ccgcaacacc ggccccuggc ucaagaaggu ccucaagugc      840

aacacccccg accccuccaa guucuucucc cagcucuccu ccgagcacgg cggcgacguc      900

cagaaguggc ucuccucccc cuuccccucc uccuccuucu cccccggcgg ccucgccccc      960

gagaucuccc cccucgaggu ccucgagcgc gacaagguca cccagcuccu ccuccagcag     1020

gacaaggucc ccgagcccgc cucccucucc uccaaccacu cccucaccuc cugcuucacc     1080

aaccagggcu acuucuucuu ccaccucccc gacgcccucg agaucgaggc cugccagguc     1140

uacuucaccu acgaccccua cuccgaggag gaccccgacg agggcgucgc cggcgccccc     1200

accggcuccu ccccccagcc ccuccagccc cucuccggcg aggacgacgc cuacugcacc     1260

uuccccuccc gcgacgaccu ccuccucuuc ucccccuccc uccucggcgg ccccuccccc     1320

cccuccaccg cccccggcgg cuccggcgcc ggcgaggagc gcaugccccc cucccuccag     1380

gagcgcgucc cccgcgacug ggacccccag ccccucggcc cccccacccc cggcgucccc     1440

gaccucgucg acuuccagcc cccccccgag cucguccucc gcgaggccgg cgaggagguc     1500

cccgacgccg gcccccgcga gggcgucucc uuccccuggu cccgcccccc cggccagggc     1560

gaguuccgcg cccucaacgc ccgccucccc cucaacaccg acgccuaccu cucccuccag     1620

gagcuccagg gccaggaccc cacccaccuc gucuga                               1656


<210>  1998
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL2-RB__Homo_sapiens__AAA59143

<400>  1998
auggccgcuc ccgcacugag cuggagacuc ccucuucuga ucuuguuacu gccacuagcc       60

accuccuggg cgucugcugc cgugaacggc acaucacagu ucacuugcuu uuacaauagu      120

agggcaaaca uuagcugugu cuggucccaa gacggggccc uccaggauac gucuugccag      180

guucacgcuu ggccggaccg gcgccgaugg aaucagaccu gugagcugcu ucccgugucg      240

caagcaucau gggccugcaa ccugauauug ggagcuccug auagccagaa gcucacaacu      300

guagacaucg ugacccugcg uguccugugu agagaaggug ugagguggcg gguuauggcc      360

auucaggauu ucaaaccauu ugagaaucuc cgcuuaaugg cgcccaucag ucuucaggug      420

guccaugugg aaacacacag augcaacauu uccugggaga ucucucaagc aagccauuau      480

uucgaaaggc accuggaguu ugaggcccgg accuuguccc cuggccauac uugggaagag      540

gcuccacugc uaacacucaa gcagaaacag gaauggauau gucuggagac ccuuacgccc      600

gacacucagu acgaguucca aguacgcguu aagccucugc agggggaauu uaccacaugg      660

ucaccaugga gucagccguu ggccuuccga acuaaacccg cagcucucgg aaaggauacc      720

aucccuuggc ugggccacuu acuggugggu cucagcgggg ccuuuggauu cauuauccuu      780

gucuaucugu ugauuaauug cagaaacaca ggcccauggc uaaagaaagu gcugaagugu      840

aauacccccg acccuucuaa auuuuucucc caacucucaa gcgagcacgg cggggaugug      900

cagaaguggc ugaguucucc auuucccucc agcucguucu cuccgggagg ucuugcgccu      960

gaaaucucac cccuggaggu cuuggaaagg gacaaaguua cgcagcuccu guuacagcaa     1020

gauaaggugc cagagccugc cucccugagu agcaaccauu cccuaacuuc uugcuucaca     1080

aaucagggcu acuuuuucuu ucaccucccc gacgcacugg agauagaggc uugucaggua     1140

uauuucaccu acgauccaua uagcgaagaa gaccccgacg aggggguggc cggagcuccu     1200

acuggcucaa guccacagcc gcuucaaccc uuguccggug aagaugacgc cuacugcaca     1260

uuuccuagcc gggaugaccu gcuccuguuc ucuccaucac uucugggagg gcccaguccu     1320

ccaagcaccg cacccggcgg cuccggggcc ggagaggagc guaugccgcc uucuuugcag     1380

gaacgcgucc caagagauug ggacccccag ccucucgguc ccccaacgcc uggcgugccc     1440

gaucugguug acuuucagcc accgccugag uuagugcuga gggaagcugg ggaggaaguc     1500

cccgaugcgg gaccacggga gggcgugucg uuccccugga gccgaccucc aggucaaggg     1560

gaguuucgcg cacuaaacgc cagacucccc cugaauaccg acgcuuaccu uuccuugcag     1620

gaacugcagg gccaggaucc uacacaucuc guauga                               1656


<210>  1999
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL2-RB__Homo_sapiens__AAA59143

<400>  1999
auggccgccc ccgcccugag cuggagacug ccccugcuga uccugcugcu gccccuggcc       60

accagcuggg ccagcgccgc cgugaacggc accagccagu ucaccugcuu cuacaacagc      120

agagccaaca ucagcugcgu guggagccag gacggcgccc ugcaggacac cagcugccag      180

gugcacgccu ggcccgacag aagaagaugg aaccagaccu gcgagcugcu gcccgugagc      240

caggccagcu gggccugcaa ccugauccug ggcgcccccg acagccagaa gcugaccacc      300

guggacaucg ugacccugag agugcugugc agagagggcg ugagauggag agugauggcc      360

auccaggacu ucaagcccuu cgagaaccug agacugaugg cccccaucag ccugcaggug      420

gugcacgugg agacccacag augcaacauc agcugggaga ucagccaggc cagccacuac      480

uucgagagac accuggaguu cgaggccaga acccugagcc ccggccacac cugggaggag      540

gccccccugc ugacccugaa gcagaagcag gaguggaucu gccuggagac ccugaccccc      600

gacacccagu acgaguucca ggugagagug aagccccugc agggcgaguu caccaccugg      660

agccccugga gccagccccu ggccuucaga accaagcccg ccgcccuggg caaggacacc      720

auccccuggc ugggccaccu gcuggugggc cugagcggcg ccuucggcuu caucauccug      780

guguaccugc ugaucaacug cagaaacacc ggccccuggc ugaagaaggu gcugaagugc      840

aacacccccg accccagcaa guucuucagc cagcugagca gcgagcacgg cggcgacgug      900

cagaaguggc ugagcagccc cuuccccagc agcagcuuca gccccggcgg ccuggccccc      960

gagaucagcc cccuggaggu gcuggagaga gacaagguga cccagcugcu gcugcagcag     1020

gacaaggugc ccgagcccgc cagccugagc agcaaccaca gccugaccag cugcuucacc     1080

aaccagggcu acuucuucuu ccaccugccc gacgcccugg agaucgaggc cugccaggug     1140

uacuucaccu acgaccccua cagcgaggag gaccccgacg agggcguggc cggcgccccc     1200

accggcagca gcccccagcc ccugcagccc cugagcggcg aggacgacgc cuacugcacc     1260

uuccccagca gagacgaccu gcugcuguuc agccccagcc ugcugggcgg ccccagcccc     1320

cccagcaccg cccccggcgg cagcggcgcc ggcgaggaga gaaugccccc cagccugcag     1380

gagagagugc ccagagacug ggacccccag ccccugggcc cccccacccc cggcgugccc     1440

gaccuggugg acuuccagcc cccccccgag cuggugcuga gagaggccgg cgaggaggug     1500

cccgacgccg gccccagaga gggcgugagc uuccccugga gcagaccccc cggccagggc     1560

gaguucagag cccugaacgc cagacugccc cugaacaccg acgccuaccu gagccugcag     1620

gagcugcagg gccaggaccc cacccaccug guguga                               1656


<210>  2000
<211>  1656
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL2-RB__Homo_sapiens__AAA59143

<400>  2000
auggccgcuc ccgcccugag cuggagacuc ccucugcuua uccugcuccu gccgcuugcg       60

accuccuggg cuucugccgc cgugaacggc acaagccagu ucacgugcuu uuacaauucc      120

cgggcuaaca uuucuugugu cuggagccaa gacggggccc ugcaggauac cuccugccag      180

guucacgcuu ggcccgaccg cagacggugg aaucagacau gugagcuccu gccugugucu      240

caagccagcu gggcgugcaa ccugauccuc ggagcccccg auucccagaa gcugaccaca      300

guggacauug ucacccuucg cgugcugugu agagaaggcg uucgguggcg cgugauggcu      360

auccaggauu ucaaaccuuu ugagaaucuc agacugaugg cccccauuag ccuucagguc      420

gugcauguug aaacacaccg gugcaacauc ucuugggaga ucucccaagc uagccauuau      480

uucgaacgcc accuggaguu ugaggccaga acccucucuc cugggcauac gugggaagag      540

gcgccgcugc ugacccucaa gcagaaacag gaauggauuu gucuggagac acuuaccccc      600

gacacacagu acgaguucca agugcggguc aagccucugc agggagaauu uaccacgugg      660

ucccccugga gccagccucu cgccuuccgc acaaaacccg cugcccuggg caaggauacc      720

aucccguggc uugggcaucu gcucguggga cugucuggcg cuuuuggcuu cauuauccug      780

guguaucucc ugauuaauug cagaaacaca gggccuuggc uuaagaaagu ccugaagugu      840

aauacccccg acccuuccaa auuuuucagc caacucuccu cugagcacgg aggcgauguu      900

cagaaguggc ugagcucccc cuuucccucc ucuuccuuca gcccuggggg acuugccccg      960

gaaaucucuc cccuggaggu gcucgaacgg gacaaaguga cccagcugcu gcuccagcaa     1020

gauaaggucc cugagcccgc cagccugucc ucuaaccaca gccuuacauc cugcuucacg     1080

aaucagggcu acuuuuucuu ucaucugccu gacgcucucg agauugaagc gugucaggug     1140

uauuucaccu acgaucccua uagcgaggaa gacccggacg aggggguugc cggagcuccu     1200

acaggcucua gcccccagcc ucugcaaccc cugagcggcg aagaugacgc cuacugcacc     1260

uuuccuucuc gcgaugaccu ucuccuguuc ucccccagcc ugcucggggg accguccccu     1320

cccucuacag cccccggcgg gagcggagcu ggcgaggaga gaaugccucc gucccugcag     1380

gaacgggugc ccagagauug ggacccucag ccccuugggc cucccacccc uggagucccc     1440

gaucuggugg acuuucagcc gccucccgag cucguucugc gcgaagccgg cgaggaagug     1500

ccugaugcgg gcccccggga gggggucucu uucccgugga gcagaccucc cggacaaggc     1560

gaguuucgcg cucugaacgc ccggcuuccu cucaauacgg acgccuaccu gucccugcag     1620

gaacuccagg ggcaggaucc cacacaccug guguga                               1656


<210>  2001
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL2-RG__Homo_sapiens__P31785

<400>  2001

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  2002
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL2-RG__Homo_sapiens__AAA59145

<400>  2002
auguugaagc caucauuacc auucacaucc cucuuauucc ugcagcugcc ccugcuggga       60

guggggcuga acacgacaau ucugacgccc aaugggaaug aagacaccac agcugauuuc      120

uuccugacca cuaugcccac ugacucccuc aguguuucca cucuaccccu cccagagguu      180

caguguuuug uguucaaugu cgaguacaug aauugcacuu ggaacagcag cucugagccc      240

cagccuacca accucacucu gcauuauugg uacaagaacu cggauaauga uaaaguccag      300

aagugcagcc acuaucuauu cucugaagaa aucacuucug gcugucaguu gcaaaaaaag      360

gagauccacc ucuaccaaac auuuguuguu cagcuccagg acccacggga acccaggaga      420

caggccacac agaugcuaaa acugcagaau cuggugaucc ccugggcucc agagaaccua      480

acacuucaca aacugaguga aucccagcua gaacugaacu ggaacaacag auucuugaac      540

cacuguuugg agcacuuggu gcaguaccgg acugacuggg accacagcug gacugaacaa      600

ucaguggauu auagacauaa guucuccuug ccuagugugg augggcagaa acgcuacacg      660

uuucguguuc ggagccgcuu uaacccacuc uguggaagug cucagcauug gagugaaugg      720

agccacccaa uccacugggg gagcaauacu ucaaaagaga auccuuuccu guuugcauug      780

gaagccgugg uuaucucugu uggcuccaug ggauugauua ucagccuucu cuguguguau      840

uucuggcugg aacggacgau gccccgaauu cccacccuga agaaccuaga ggaucuuguu      900

acugaauacc acgggaacuu uucggccugg aguggugugu cuaagggacu ggcugagagu      960

cugcagccag acuacaguga acgacucugc cucgucagug agauuccccc aaaaggaggg     1020

gcccuugggg aggggccugg ggccucccca ugcaaccagc auagccccua cugggccccc     1080

ccauguuaca cccuaaagcc ugaaaccuga                                      1110


<210>  2003
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL2-RG__Homo_sapiens__AAA59145

<400>  2003
augcugaagc ccagccuccc guucaccucc cugcuguucc uccagcugcc ccugcucggc       60

guggggcuga acaccacgau ccugaccccc aacggcaacg aggacaccac cgccgacuuc      120

uuccucacga ccaugcccac cgacagccug uccgucagca cccugccgcu ccccgaggug      180

cagugcuucg uguucaacgu cgaguacaug aacugcacgu ggaacuccag cuccgagccc      240

cagcccacca accugacccu gcacuacugg uacaagaaca gcgacaacga caaggugcag      300

aagugcuccc acuaccucuu cagcgaggag aucaccuccg ggugccagcu gcagaagaag      360

gagauccacc uguaccagac guucgugguc cagcuccagg acccgcgcga gccccggcgc      420

caggccaccc agaugcugaa gcugcagaac cucgugaucc ccugggcgcc cgagaaccug      480

acccugcaca agcucagcga gucccagcug gagcugaacu ggaacaaccg guuccucaac      540

cacugccugg agcaccuggu gcaguaccgc accgacuggg accacagcug gacggagcag      600

uccgucgacu accggcacaa guucagccuc ccguccgugg acggccagaa gcgcuacacc      660

uuccgggugc gcagccgguu caacccccug ugcggguccg cccagcacug gagcgagugg      720

agccacccca uccacugggg cuccaacacc agcaaggaga accccuuccu guucgcccuc      780

gaggccgucg ugaucuccgu gggcagcaug gggcugauca ucucccugcu cugcgucuac      840

uucuggcugg agcgcaccau gccgcggauc cccacgcuga agaaccucga ggaccuggug      900

accgaguacc acggcaacuu cagcgccugg uccgggguga gcaagggccu ggcggagucc      960

cuccagcccg acuacagcga gcgccugugc cuggucuccg agaucccgcc caagggcggg     1020

gcccucggcg aggggcccgg cgccagcccc ugcaaccagc acucccccua cugggccccg     1080

cccugcuaca cccugaagcc cgagaccuga                                      1110


<210>  2004
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL2-RG__Homo_sapiens__AAA59145

<400>  2004
augcucaagc ccucccuccc cuucaccucc cuccucuucc uccagcuccc ccuccucggc       60

gucggccuca acaccaccau ccucaccccc aacggcaacg aggacaccac cgccgacuuc      120

uuccucacca ccaugcccac cgacucccuc uccgucucca cccucccccu ccccgagguc      180

cagugcuucg ucuucaacgu cgaguacaug aacugcaccu ggaacuccuc cuccgagccc      240

cagcccacca accucacccu ccacuacugg uacaagaacu ccgacaacga caagguccag      300

aagugcuccc acuaccucuu cuccgaggag aucaccuccg gcugccagcu ccagaagaag      360

gagauccacc ucuaccagac cuucgucguc cagcuccagg acccccgcga gccccgccgc      420

caggccaccc agaugcucaa gcuccagaac cucgucaucc ccugggcccc cgagaaccuc      480

acccuccaca agcucuccga gucccagcuc gagcucaacu ggaacaaccg cuuccucaac      540

cacugccucg agcaccucgu ccaguaccgc accgacuggg accacuccug gaccgagcag      600

uccgucgacu accgccacaa guucucccuc cccuccgucg acggccagaa gcgcuacacc      660

uuccgcgucc gcucccgcuu caacccccuc ugcggcuccg cccagcacug guccgagugg      720

ucccacccca uccacugggg cuccaacacc uccaaggaga accccuuccu cuucgcccuc      780

gaggccgucg ucaucuccgu cggcuccaug ggccucauca ucucccuccu cugcgucuac      840

uucuggcucg agcgcaccau gccccgcauc cccacccuca agaaccucga ggaccucguc      900

accgaguacc acggcaacuu cuccgccugg uccggcgucu ccaagggccu cgccgagucc      960

cuccagcccg acuacuccga gcgccucugc cucgucuccg agaucccccc caagggcggc     1020

gcccucggcg agggccccgg cgccuccccc ugcaaccagc acucccccua cugggccccc     1080

cccugcuaca cccucaagcc cgagaccuga                                      1110


<210>  2005
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL2-RG__Homo_sapiens__AAA59145

<400>  2005
augcugaagc ccagccuccc uuucaccucc cuucuguuuu ugcaguuacc acugcuaggc       60

guggggcuca acacaacuau ccugacgccg aauggaaacg aggacaccac agccgauuuc      120

uuucuuacua ccaugcccac agacucucug ucagucagua ccuugccucu cccagaaguu      180

caaugcuucg uguuuaaugu agaguacaug aacuguacuu ggaauagcuc cucugaaccc      240

cagccuacaa accugacccu gcacuauugg uacaaaaauu cggauaacga caaggugcag      300

aaaugcucac auuaucucuu cagcgaggaa aucacgagug guugucaguu acaaaagaaa      360

gagauacacc uguaccagac uuuugucgug cagcuucagg auccaagaga gcccaggcgg      420

caagcuaccc agauguugaa gcugcagaau cuaguuaucc cuugggcacc agaaaaccuc      480

acacugcaua aacuuuccga gucucagcug gaauugaauu ggaacaaucg cuuccucaac      540

cacugccugg agcauuuagu gcaauaucga acugacuggg aucacagcug gaccgagcag      600

uccgucgacu accgucacaa guuuucacug ccgagugugg auggccagaa gagauauaca      660

uucaggguac ggagccgcuu uaauccccuc ugugggucug cccaacauug guccgaaugg      720

ucacacccua uucauugggg aagcaacacc aguaaagaga acccauuccu uuuugcgcug      780

gaagcuguug ugaucucugu cggcuccaug gguuugauua ucagccuacu gugcguguac      840

uucuggcucg agagaacgau gcccaggaua ccuacucuga agaaucuuga agaccuggug      900

acagaguacc acgggaacuu cucggccugg ucuggagucu ccaaaggcuu ggcagaguca      960

cuccagccag auuauaguga acggcugugu uuaguuagcg agauuccccc gaagggcggg     1020

gcccugggag aagguccugg cgcuuccccc ugcaaucagc acucuccaua cugggcaccu     1080

cccuguuaua cccuaaagcc agagacuuga                                      1110


<210>  2006
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL2-RG__Homo_sapiens__AAA59145

<400>  2006
augcugaagc ccagccugcc cuucaccagc cugcuguucc ugcagcugcc ccugcugggc       60

gugggccuga acaccaccau ccugaccccc aacggcaacg aggacaccac cgccgacuuc      120

uuccugacca ccaugcccac cgacagccug agcgugagca cccugccccu gcccgaggug      180

cagugcuucg uguucaacgu ggaguacaug aacugcaccu ggaacagcag cagcgagccc      240

cagcccacca accugacccu gcacuacugg uacaagaaca gcgacaacga caaggugcag      300

aagugcagcc acuaccuguu cagcgaggag aucaccagcg gcugccagcu gcagaagaag      360

gagauccacc uguaccagac cuucguggug cagcugcagg accccagaga gcccagaaga      420

caggccaccc agaugcugaa gcugcagaac cuggugaucc ccugggcccc cgagaaccug      480

acccugcaca agcugagcga gagccagcug gagcugaacu ggaacaacag auuccugaac      540

cacugccugg agcaccuggu gcaguacaga accgacuggg accacagcug gaccgagcag      600

agcguggacu acagacacaa guucagccug cccagcgugg acggccagaa gagauacacc      660

uucagaguga gaagcagauu caacccccug ugcggcagcg cccagcacug gagcgagugg      720

agccacccca uccacugggg cagcaacacc agcaaggaga accccuuccu guucgcccug      780

gaggccgugg ugaucagcgu gggcagcaug ggccugauca ucagccugcu gugcguguac      840

uucuggcugg agagaaccau gcccagaauc cccacccuga agaaccugga ggaccuggug      900

accgaguacc acggcaacuu cagcgccugg agcggcguga gcaagggccu ggccgagagc      960

cugcagcccg acuacagcga gagacugugc cuggugagcg agaucccccc caagggcggc     1020

gcccugggcg agggccccgg cgccagcccc ugcaaccagc acagccccua cugggccccc     1080

cccugcuaca cccugaagcc cgagaccuga                                      1110


<210>  2007
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL2-RG__Homo_sapiens__AAA59145

<400>  2007
augcugaagc ccagccuccc uuucaccucc cugcuuuuuc ugcagcuccc gcugcuuggc       60

guggggcuga acacaacgau ccucaccccc aauggaaacg aggacacaac cgccgauuuc      120

uuucugacaa ccaugccuac agacucucug agcgucucca cccucccccu gccugaaguu      180

caaugcuucg uguuuaaugu ggaguacaug aacuguacgu ggaacucuag cuccgaaccc      240

cagccuacca aucuuacacu gcacuauugg uacaaaaauu cugauaacga caagguccag      300

aaaugcagcc auuaucucuu cuccgaggaa aucaccagcg gcugucagcu gcaaaagaaa      360

gagauccacc uuuaccagac auuugugguu cagcugcagg auccgagaga gccccggcgc      420

caagccaccc agaugcucaa gcugcagaau cuggugauuc cuugggcccc cgaaaaccuc      480

acgcugcaua aacuuucuga gucccagcug gaacucaauu ggaacaauag auuccugaac      540

cacugccuug agcaucuggu ccaauaucgg acagacuggg aucacagcug gaccgagcag      600

ucuguggacu accgccacaa guuuucccuc ccuagcguug augggcagaa gagauauaca      660

uuccgggugc gcucuagauu uaauccccug uguggauccg cgcaacauug gagcgaaugg      720

ucccacccga uccauugggg cucuaacacc agcaaagaga acccuuuccu guuugcucuc      780

gaagccgucg ugauuuccgu ggggagcaug ggacugauca ucucucuucu gugcgucuac      840

uucuggcucg agcggaccau gccccgcauu ccuacacuga agaaucuuga agaccugguu      900

acggaguacc acggcaacuu cuccgccugg agcggcgugu cuaaagggcu cgcugagagc      960

cugcagcccg auuauuccga aagacugugu cucgugucug agauuccccc uaagggaggc     1020

gcccuggggg aaggaccggg cgcuagcccc ugcaaucagc acuccccuua cugggcuccc     1080

ccuuguuaua cccuuaagcc cgagacauga                                      1110


<210>  2008
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IMP3__Homo_sapiens__Q9NV31

<400>  2008

Met Val Arg Lys Leu Lys Phe His Glu Gln Lys Leu Leu Lys Gln Val 
1               5                   10                  15      


Asp Phe Leu Asn Trp Glu Val Thr Asp His Asn Leu His Glu Leu Arg 
            20                  25                  30          


Val Leu Arg Arg Tyr Arg Leu Gln Arg Arg Glu Asp Tyr Thr Arg Tyr 
        35                  40                  45              


Asn Gln Leu Ser Arg Ala Val Arg Glu Leu Ala Arg Arg Leu Arg Asp 
    50                  55                  60                  


Leu Pro Glu Arg Asp Gln Phe Arg Val Arg Ala Ser Ala Ala Leu Leu 
65                  70                  75                  80  


Asp Lys Leu Tyr Ala Leu Gly Leu Val Pro Thr Arg Gly Ser Leu Glu 
                85                  90                  95      


Leu Cys Asp Phe Val Thr Ala Ser Ser Phe Cys Arg Arg Arg Leu Pro 
            100                 105                 110         


Thr Val Leu Leu Lys Leu Arg Met Ala Gln His Leu Gln Ala Ala Val 
        115                 120                 125             


Ala Phe Val Glu Gln Gly His Val Arg Val Gly Pro Asp Val Val Thr 
    130                 135                 140                 


Asp Pro Ala Phe Leu Val Thr Arg Ser Met Glu Asp Phe Val Thr Trp 
145                 150                 155                 160 


Val Asp Ser Ser Lys Ile Lys Arg His Val Leu Glu Tyr Asn Glu Glu 
                165                 170                 175     


Arg Asp Asp Phe Asp Leu Glu Ala 
            180                 


<210>  2009
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IMP3__Homo_sapiens__AAH06487

<400>  2009
auggugcgga agcuuaaguu ccacgagcag aagcugcuga agcaggugga cuuccugaac       60

ugggagguca ccgaccacaa ccugcacgag cugcgcgugc ugcggcguua ccggcugcag      120

cggcgggagg acuacacgcg cuacaaccag cugagccgug ccgugcguga gcuggcgcgg      180

cgccugcgcg accugcccga acgcgaccag uuccgcgugc gcgcuucggc cgcgcugcug      240

gacaagcugu augcucucgg cuuggugccc acgcgcgguu cgcuggagcu cugcgacuuc      300

gucacggccu cguccuucug ccgccgccgc cuccccaccg ugcuccucaa gcugcgcaug      360

gcgcagcacc uucaggcugc aguggccuuu guggagcaag ggcacguacg cgugggcccu      420

gacgugguua ccgaccccgc cuuccuuguc acgcgcagca uggaggacuu ugucacuugg      480

guggacucgu ccaagaucaa gcggcacgug cuagaguaca augaggagcg cgaugacuuc      540

gaucuggaag ccuag                                                       555


<210>  2010
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IMP3__Homo_sapiens__AAH06487

<400>  2010
auggugcgca agcugaaguu ccacgagcag aagcuccuga agcaggucga cuuccugaac       60

ugggagguga ccgaccacaa ccuccacgag cugcgggugc ugcgccggua ccgccuccag      120

cggcgcgagg acuacacccg guacaaccag cugagccgcg ccguccggga gcuggcccgc      180

cggcuccgcg accugcccga gcgggaccag uuccgcgugc gggcguccgc cgcccugcuc      240

gacaagcugu acgcccuggg ccucgugccg acgcgcggga gccuggagcu gugcgacuuc      300

gucaccgccu ccagcuucug ccggcgccgg cuccccaccg ugcugcugaa gcuccgcaug      360

gcgcagcacc uccaggccgc cguggccuuc gucgagcagg gccacgugcg gguggggccc      420

gacgucguga ccgaccccgc guuccuggug acgcgcucca uggaggacuu cgucaccugg      480

guggacagcu ccaagaucaa gcgccacgug cuggaguaca acgaggagcg ggacgacuuc      540

gaccuggagg ccuga                                                       555


<210>  2011
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IMP3__Homo_sapiens__AAH06487

<400>  2011
augguccgca agcucaaguu ccacgagcag aagcuccuca agcaggucga cuuccucaac       60

ugggagguca ccgaccacaa ccuccacgag cuccgcgucc uccgccgcua ccgccuccag      120

cgccgcgagg acuacacccg cuacaaccag cucucccgcg ccguccgcga gcucgcccgc      180

cgccuccgcg accuccccga gcgcgaccag uuccgcgucc gcgccuccgc cgcccuccuc      240

gacaagcucu acgcccucgg ccucgucccc acccgcggcu cccucgagcu cugcgacuuc      300

gucaccgccu ccuccuucug ccgccgccgc cuccccaccg uccuccucaa gcuccgcaug      360

gcccagcacc uccaggccgc cgucgccuuc gucgagcagg gccacguccg cgucggcccc      420

gacgucguca ccgaccccgc cuuccucguc acccgcucca uggaggacuu cgucaccugg      480

gucgacuccu ccaagaucaa gcgccacguc cucgaguaca acgaggagcg cgacgacuuc      540

gaccucgagg ccuga                                                       555


<210>  2012
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IMP3__Homo_sapiens__AAH06487

<400>  2012
auggugagaa agcugaaauu ccacgagcag aagcuccuua aacaagucga cuuucugaac       60

ugggaaguua ccgaucauaa uuugcacgag uuaagggugc ugcggcgcua ccgacuacag      120

cguagagaag acuauacaag guacaaccag cucagccggg ccguacgcga gcuggcuaga      180

aggcuucggg aucugcccga acgcgaccag uuccgaguga gagcauccgc cgcguugcuc      240

gauaagcugu augcucuggg ccucgucccu acuagggggu cuuuagagcu gugcgacuuu      300

gugacggccu caaguuucug ucggcgucgc cuuccaaccg uuuugcugaa acuaagaaug      360

gcacaacauc uccaggccgc uguggcauuu gucgagcagg gacacgugag gguagguccg      420

gauguuguga cagaccccgc cuuccugguc acucggagca uggaagauuu ugugaccugg      480

guggacuccu cuaagaucaa gcgacauguc cuugaguaca augaggaacg cgaugacuuc      540

gaucuggagg cuuga                                                       555


<210>  2013
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IMP3__Homo_sapiens__AAH06487

<400>  2013
auggugagaa agcugaaguu ccacgagcag aagcugcuga agcaggugga cuuccugaac       60

ugggagguga ccgaccacaa ccugcacgag cugagagugc ugagaagaua cagacugcag      120

agaagagagg acuacaccag auacaaccag cugagcagag ccgugagaga gcuggccaga      180

agacugagag accugcccga gagagaccag uucagaguga gagccagcgc cgcccugcug      240

gacaagcugu acgcccuggg ccuggugccc accagaggca gccuggagcu gugcgacuuc      300

gugaccgcca gcagcuucug cagaagaaga cugcccaccg ugcugcugaa gcugagaaug      360

gcccagcacc ugcaggccgc cguggccuuc guggagcagg gccacgugag agugggcccc      420

gacgugguga ccgaccccgc cuuccuggug accagaagca uggaggacuu cgugaccugg      480

guggacagca gcaagaucaa gagacacgug cuggaguaca acgaggagag agacgacuuc      540

gaccuggagg ccuga                                                       555


<210>  2014
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IMP3__Homo_sapiens__AAH06487

<400>  2014
auggugagaa agcugaaauu ccacgagcag aagcuccuga aacaagucga cuuucuuaac       60

ugggaaguua ccgaucauaa ucugcacgag cuccgggugc ugcgcagaua ccggcuucag      120

cgcagagaag acuauacacg guacaaccag cugagccgcg ccgugagaga gcucgcucgg      180

cgccugagag aucugcccga acgggaccag uuccgcguca gagccuccgc ggcucuccug      240

gauaaacuuu augcccuggg ccucgugccu acgcgggggu cucuggagcu uugcgacuuu      300

guuaccgcca gcuccuucug ucgcagacgg cugccgacag ugcuccugaa gcugagaaug      360

gcucaacauc uccaggccgc ugucgccuuu guggagcagg gacacguucg cgugggcccc      420

gaugucguga ccgacccugc guuccuggug acacggucua uggaagauuu ugucaccugg      480

guugacagcu ccaagaucaa gagacaugug cuugaguaca augaggaacg cgaugacuuc      540

gaucuggagg ccuga                                                       555


<210>  2015
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ITA5__Homo_sapiens__P08648

<400>  2015

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp Ile Ile Ile Leu Ala Ile Leu Phe 
        995                 1000                1005            


Gly Leu Leu Leu Leu Gly Leu Leu Ile Tyr Ile Leu Tyr Lys Leu Gly 
    1010                1015                1020                


Phe Phe Lys Arg Ser Leu Pro Tyr Gly Thr Ala Met Glu Lys Ala Gln 
1025                1030                1035                1040


Leu Lys Pro Pro Ala Thr Ser Asp Ala 
                1045                


<210>  2016
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ITA5__Homo_sapiens__AAH08786

<400>  2016
auggggagcc ggacgccaga guccccucuc cacgccgugc agcugcgcug gggcccccgg       60

cgccgacccc cgcugcugcc gcugcuguug cugcugcugc cgccgccacc cagggucggg      120

ggcuucaacu uagacgcgga ggccccagca guacucucgg ggcccccggg cuccuucuuc      180

ggauucucag uggaguuuua ccggccggga acagacgggg ucagugugcu ggugggagca      240

cccaaggcua auaccagcca gccaggagug cugcagggug gugcugucua ccucuguccu      300

uggggugcca gccccacaca gugcaccccc auugaauuug acagcaaagg cucucggcuc      360

cuggaguccu cacuguccag cucagaggga gaggagccug uggaguacaa guccuugcag      420

ugguucgggg caacaguucg agcccauggc uccuccaucu uggcaugcgc uccacuguac      480

agcuggcgca cagagaagga gccacugagc gaccccgugg gcaccugcua ccucuccaca      540

gauaacuuca cccgaauucu ggaguaugca cccugccgcu cagauuucag cugggcagca      600

ggacaggguu acugccaagg aggcuucagu gccgaguuca ccaagacugg ccgugugguu      660

uuagguggac caggaagcua uuucuggcaa ggccagaucc ugucugccac ucaggagcag      720

auugcagaau cuuauuaccc cgaguaccug aucaaccugg uucaggggca gcugcagacu      780

cgccaggcca guuccaucua ugaugacagc uaccuaggau acucuguggc uguuggugaa      840

uucaguggug augacacaga agacuuuguu gcuggugugc ccaaagggaa ccucacuuac      900

ggcuauguca ccauccuuaa uggcucagac auucgauccc ucuacaacuu cucaggggaa      960

cagauggccu ccuacuuugg cuaugcagug gccgccacag acgucaaugg ggacgggcug     1020

gaugacuugc uggugggggc accccugcuc auggaucgga ccccugacgg gcggccucag     1080

gaggugggca gggucuacgu cuaccugcag cacccagccg gcauagagcc cacgcccacc     1140

cuuacccuca cuggccauga ugaguuuggc cgauuuggca gcuccuugac cccccugggg     1200

gaccuggacc aggauggcua caaugaugug gccaucgggg cucccuuugg uggggagacc     1260

cagcagggag uaguguuugu auuuccuggg ggcccaggag ggcugggcuc uaagccuucc     1320

cagguucugc agccccugug ggcagccagc cacaccccag acuucuuugg cucugcccuu     1380

cgaggaggcc gagaccugga uggcaaugga uauccugauc ugauuguggg guccuuuggu     1440

guggacaagg cugugguaua caggggccgc cccaucgugu ccgcuagugc cucccucacc     1500

aucuuccccg ccauguucaa cccagaggag cggagcugca gcuuagaggg gaacccugug     1560

gccugcauca accuuagcuu cugccucaau gcuucuggaa aacacguugc ugacuccauu     1620

gguuucacag uggaacuuca gcuggacugg cagaagcaga agggaggggu acggcgggca     1680

cuguuccugg ccuccaggca ggcaacccug acccagaccc ugcucaucca gaauggggcu     1740

cgagaggauu gcagagagau gaagaucuac cucaggaacg agucagaauu ucgagacaaa     1800

cucucgccga uucacaucgc ucucaacuuc uccuuggacc cccaagcccc aguggacagc     1860

cacggccuca ggccagcccu acauuaucag agcaagagcc ggauagagga caaggcucag     1920

aucuugcugg acuguggaga agacaacauc ugugugccug accugcagcu ggaaguguuu     1980

ggggagcaga accaugugua ccugggugac aagaaugccc ugaaccucac uuuccaugcc     2040

cagaaugugg gugagggugg cgccuaugag gcugagcuuc gggucaccgc cccuccagag     2100

gcugaguacu caggacucgu cagacaccca gggaacuucu ccagccugag cugugacuac     2160

uuugccguga accagagccg ccugcuggug ugugaccugg gcaaccccau gaaggcagga     2220

gccagucugu gggguggccu ucgguuuaca gucccucauc uccgggacac uaagaaaacc     2280

auccaguuug acuuccagau ccucagcaag aaucucaaca acucgcaaag cgacgugguu     2340

uccuuucggc ucuccgugga ggcucaggcc caggucaccc ugaacggugu cuccaagccu     2400

gaggcagugc uauucccagu aagcgacugg cauccccgag accagccuca gaaggaggag     2460

gaccugggac cugcugucca ccaugucuau gagcucauca accaaggccc cagcuccauu     2520

agccagggug ugcuggaacu cagcuguccc caggcucugg aaggucagca gcuccuauau     2580

gugaccagag uuacgggacu caacugcacc accaaucacc ccauuaaccc aaagggccug     2640

gaguuggauc ccgaggguuc ccugcaccac cagcaaaaac gggaagcucc aagccgcagc     2700

ucugcuuccu cgggaccuca gauccugaaa ugcccggagg cugaguguuu caggcugcgc     2760

ugugagcucg ggccccugca ccaacaagag agccaaaguc ugcaguugca uuuccgaguc     2820

ugggccaaga cuuucuugca gcgggagcac cagccauuua gccugcagug ugaggcugug     2880

uacaaagccc ugaagaugcc cuaccgaauc cugccucggc agcugcccca aaaagagcgu     2940

cagguggcca cagcugugca auggaccaag gcagaaggca gcuauggcgu cccacugugg     3000

aucaucaucc uagccauccu guuuggccuc cugcuccuag gucuacucau cuacauccuc     3060

uacaagcuug gauucuucaa acgcucccuc ccauauggca ccgccaugga aaaagcucag     3120

cucaagccuc cagccaccuc ugaugccuga                                      3150


<210>  2017
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ITA5__Homo_sapiens__AAH08786

<400>  2017
augggcagcc gcacccccga guccccgcug cacgccgugc agcuccggug ggggccccgc       60

cggcgccccc cccugcugcc gcuccugcug cuccugcugc cccccccccc gcgggucggc      120

ggguucaacc ucgacgccga ggcgcccgcc gugcugagcg gcccccccgg guccuucuuc      180

ggcuucagcg uggaguucua ccgcccgggc accgacgggg ucuccgugcu ggugggcgcc      240

cccaaggcca acacgagcca gcccgggguc cuccagggcg gggccgugua ccugugcccc      300

uggggcgcgu ccccgaccca gugcaccccc aucgaguucg acagcaaggg cucccggcug      360

cucgagagcu cccugagcuc cagcgagggg gaggagcccg uggaguacaa gucccugcag      420

ugguucggcg ccaccguccg cgcccacggg agcuccaucc ucgccugcgc gccccuguac      480

agcuggcgga cggagaagga gccgcugucc gaccccgugg gcaccugcua ccucagcacc      540

gacaacuuca cccgcauccu ggaguacgcc cccugccgga gcgacuucuc cugggccgcc      600

ggccaggggu acugccaggg cggguucagc gccgaguuca cgaagaccgg ccgcgugguc      660

cuggggggcc ccggcuccua cuucuggcag gggcagaucc ucagcgcgac ccaggagcag      720

aucgccgagu ccuacuaccc ggaguaccug aucaaccugg ugcagggcca gcuccagacc      780

cggcaggcca gcuccaucua cgacgacagc uaccuggggu acuccguggc cgucggcgag      840

uucagcgggg acgacacgga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggguacguca ccauccucaa cggcuccgac auccgcagcc uguacaacuu cuccggggag      960

cagauggcga gcuacuucgg cuacgccgug gccgccaccg acgugaacgg ggacggccug     1020

gacgaccucc uggucggcgc cccccugcuc auggaccgga cgcccgacgg gcgcccgcag     1080

gaggugggcc ggguguacgu cuaccugcag caccccgcgg ggaucgagcc caccccgacc     1140

cugacccuca cgggccacga cgaguucggc cgcuucgggu ccagccugac cccccugggc     1200

gaccucgacc aggacgggua caacgacgug gccaucggcg cccccuucgg gggcgagacc     1260

cagcagggcg ucguguucgu guuccccggg ggcccggggg gccugggguc caagcccagc     1320

cagguccugc agccccucug ggccgccucc cacacccccg acuucuucgg cagcgcgcug     1380

cggggcgggc gcgaccugga cggcaacggg uacccggacc ucaucguggg cagcuucggg     1440

guggacaagg ccgucgugua ccggggccgc cccaucgugu ccgccagcgc cucccugacg     1500

aucuuccccg cgauguucaa ccccgaggag cgcagcugcu cccuggaggg caacccgguc     1560

gccugcauca accugagcuu cugccucaac gccuccggga agcacguggc cgacagcauc     1620

ggcuucaccg uggagcugca gcuggacugg cagaagcaga aggggggcgu ccggcgcgcc     1680

cucuuccugg cgucccggca ggccacccug acccagacgc uccugaucca gaacggggcc     1740

cgcgaggacu gccgggagau gaagaucuac cugcgcaacg agagcgaguu ccgggacaag     1800

cucuccccca uccacaucgc ccugaacuuc agccuggacc cccaggcccc cguggacucc     1860

cacggccucc gcccggcgcu gcacuaccag agcaaguccc ggaucgagga caaggcccag     1920

auccugcucg acugcggcga ggacaacauc ugcgugcccg accugcagcu ggaggucuuc     1980

ggggagcaga accacgugua ccucggcgac aagaacgccc ugaaccugac cuuccacgcc     2040

cagaacgugg gggagggcgg cgccuacgag gcggagcucc gcgucaccgc cccccccgag     2100

gccgaguaca gcgggcuggu gcggcacccg ggcaacuucu ccagccugag cugcgacuac     2160

uucgccguga accagucccg ccuccugguc ugcgaccugg ggaaccccau gaaggcgggc     2220

gccagccucu gggggggccu gcgguucacc gugccccacc ugcgcgacac gaagaagacc     2280

auccaguucg acuuccagau ccucuccaag aaccugaaca acagccaguc cgacgugguc     2340

agcuuccggc uguccgugga ggcccaggcc caggugaccc ucaacggcgu cagcaagccc     2400

gaggccgugc uguucccggu guccgacugg cacccccgcg accagcccca gaaggaggag     2460

gaccuggggc cggcggucca ccacguguac gagcucauca accagggccc cagcuccauc     2520

agccaggggg ugcuggagcu guccugcccc caggcccucg agggccagca gcugcuguac     2580

gucacccggg ugacggggcu caacugcacc accaaccacc ccaucaaccc gaagggccug     2640

gagcuggacc ccgagggcag ccuccaccac cagcagaagc gcgaggcccc cucccggagc     2700

uccgccagcu ccgggcccca gauccugaag ugcccggagg ccgagugcuu ccgccugcgc     2760

ugcgagcucg gcccccugca ccagcaggag agccagagcc ugcagcucca cuuccgggug     2820

ugggcgaaga ccuuccugca gcgcgagcac cagcccuucu cccugcagug cgaggccguc     2880

uacaaggccc ucaagaugcc cuaccggauc cugccgcgcc agcugcccca gaaggagcgg     2940

cagguggcca ccgccgugca guggacgaag gcggagggga gcuacggcgu cccccucugg     3000

aucaucaucc uggccauccu guucgggcuc cugcugcucg gccugcugau cuacauccuc     3060

uacaagcugg gcuucuucaa gcgcucccug cccuacggga ccgccaugga gaaggcccag     3120

cucaagccgc ccgcgaccag cgacgccuga                                      3150


<210>  2018
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ITA5__Homo_sapiens__AAH08786

<400>  2018
augggcuccc gcacccccga guccccccuc cacgccgucc agcuccgcug gggcccccgc       60

cgccgccccc cccuccuccc ccuccuccuc cuccuccucc cccccccccc ccgcgucggc      120

ggcuucaacc ucgacgccga ggcccccgcc guccucuccg gcccccccgg cuccuucuuc      180

ggcuucuccg ucgaguucua ccgccccggc accgacggcg ucuccguccu cgucggcgcc      240

cccaaggcca acaccuccca gcccggcguc cuccagggcg gcgccgucua ccucugcccc      300

uggggcgccu cccccaccca gugcaccccc aucgaguucg acuccaaggg cucccgccuc      360

cucgaguccu cccucuccuc cuccgagggc gaggagcccg ucgaguacaa gucccuccag      420

ugguucggcg ccaccguccg cgcccacggc uccuccaucc ucgccugcgc cccccucuac      480

uccuggcgca ccgagaagga gccccucucc gaccccgucg gcaccugcua ccucuccacc      540

gacaacuuca cccgcauccu cgaguacgcc cccugccgcu ccgacuucuc cugggccgcc      600

ggccagggcu acugccaggg cggcuucucc gccgaguuca ccaagaccgg ccgcgucguc      660

cucggcggcc ccggcuccua cuucuggcag ggccagaucc ucuccgccac ccaggagcag      720

aucgccgagu ccuacuaccc cgaguaccuc aucaaccucg uccagggcca gcuccagacc      780

cgccaggccu ccuccaucua cgacgacucc uaccucggcu acuccgucgc cgucggcgag      840

uucuccggcg acgacaccga ggacuucguc gccggcgucc ccaagggcaa ccucaccuac      900

ggcuacguca ccauccucaa cggcuccgac auccgcuccc ucuacaacuu cuccggcgag      960

cagauggccu ccuacuucgg cuacgccguc gccgccaccg acgucaacgg cgacggccuc     1020

gacgaccucc ucgucggcgc cccccuccuc auggaccgca cccccgacgg ccgcccccag     1080

gaggucggcc gcgucuacgu cuaccuccag caccccgccg gcaucgagcc cacccccacc     1140

cucacccuca ccggccacga cgaguucggc cgcuucggcu ccucccucac cccccucggc     1200

gaccucgacc aggacggcua caacgacguc gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ucgucuucgu cuuccccggc ggccccggcg gccucggcuc caagcccucc     1320

cagguccucc agccccucug ggccgccucc cacacccccg acuucuucgg cuccgcccuc     1380

cgcggcggcc gcgaccucga cggcaacggc uaccccgacc ucaucgucgg cuccuucggc     1440

gucgacaagg ccgucgucua ccgcggccgc cccaucgucu ccgccuccgc cucccucacc     1500

aucuuccccg ccauguucaa ccccgaggag cgcuccugcu cccucgaggg caaccccguc     1560

gccugcauca accucuccuu cugccucaac gccuccggca agcacgucgc cgacuccauc     1620

ggcuucaccg ucgagcucca gcucgacugg cagaagcaga agggcggcgu ccgccgcgcc     1680

cucuuccucg ccucccgcca ggccacccuc acccagaccc uccucaucca gaacggcgcc     1740

cgcgaggacu gccgcgagau gaagaucuac cuccgcaacg aguccgaguu ccgcgacaag     1800

cucuccccca uccacaucgc ccucaacuuc ucccucgacc cccaggcccc cgucgacucc     1860

cacggccucc gccccgcccu ccacuaccag uccaaguccc gcaucgagga caaggcccag     1920

auccuccucg acugcggcga ggacaacauc ugcguccccg accuccagcu cgaggucuuc     1980

ggcgagcaga accacgucua ccucggcgac aagaacgccc ucaaccucac cuuccacgcc     2040

cagaacgucg gcgagggcgg cgccuacgag gccgagcucc gcgucaccgc cccccccgag     2100

gccgaguacu ccggccucgu ccgccacccc ggcaacuucu ccucccucuc cugcgacuac     2160

uucgccguca accagucccg ccuccucguc ugcgaccucg gcaaccccau gaaggccggc     2220

gccucccucu ggggcggccu ccgcuucacc gucccccacc uccgcgacac caagaagacc     2280

auccaguucg acuuccagau ccucuccaag aaccucaaca acucccaguc cgacgucguc     2340

uccuuccgcc ucuccgucga ggcccaggcc caggucaccc ucaacggcgu cuccaagccc     2400

gaggccgucc ucuuccccgu cuccgacugg cacccccgcg accagcccca gaaggaggag     2460

gaccucggcc ccgccgucca ccacgucuac gagcucauca accagggccc cuccuccauc     2520

ucccagggcg uccucgagcu cuccugcccc caggcccucg agggccagca gcuccucuac     2580

gucacccgcg ucaccggccu caacugcacc accaaccacc ccaucaaccc caagggccuc     2640

gagcucgacc ccgagggcuc ccuccaccac cagcagaagc gcgaggcccc cucccgcucc     2700

uccgccuccu ccggccccca gauccucaag ugccccgagg ccgagugcuu ccgccuccgc     2760

ugcgagcucg gcccccucca ccagcaggag ucccaguccc uccagcucca cuuccgcguc     2820

ugggccaaga ccuuccucca gcgcgagcac cagcccuucu cccuccagug cgaggccguc     2880

uacaaggccc ucaagaugcc cuaccgcauc cucccccgcc agcuccccca gaaggagcgc     2940

caggucgcca ccgccgucca guggaccaag gccgagggcu ccuacggcgu cccccucugg     3000

aucaucaucc ucgccauccu cuucggccuc cuccuccucg gccuccucau cuacauccuc     3060

uacaagcucg gcuucuucaa gcgcucccuc cccuacggca ccgccaugga gaaggcccag     3120

cucaagcccc ccgccaccuc cgacgccuga                                      3150


<210>  2019
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ITA5__Homo_sapiens__AAH08786

<400>  2019
augggcagca gaacccccga guccccucug cacgccgugc agcucaggug ggggccacgg       60

cgccgaccgc cccuucugcc uuuguuacug cuacuccugc cacccccucc acgugucgga      120

gguuucaacc uugacgcuga agcacccgcc guucugucug gcccuccagg gucauuuuuc      180

ggauuuagug uggaguucua cagaccgggc acagauggug uaagcguguu ggucggggcg      240

cccaaggcua auacuuccca accuggagug cuccagggcg gcgccguuua ucugugccca      300

uggggagcau cucccacgca guguaccccu aucgaauuug acucgaaagg gucaaggcug      360

cucgagagca guuuauccuc uagcgaaggu gaggagccag uggaauacaa gucccugcag      420

ugguucggcg ccacaguccg ggcucauggg ucaaguauuc uugcaugcgc ccccuuguau      480

agcuggcgca cugagaaaga accgcugucu gauccugugg gaaccuguua ccuauccaca      540

gacaacuuua ccagaauacu cgaguaugcu cccugcaggu cagauuucag cugggccgcg      600

ggccaagguu acugucaagg gggauuuagu gcagaguuca cuaagacagg ccggguaguu      660

cugggcgggc caggaucuua uuuuuggcag ggucagaucc uuuccgccac ccaggaacag      720

auugcugaga gcuacuaccc ugaauaucug aucaauuugg ugcagggcca gcuccaaacg      780

cgccaggccu cgucuauuua cgacgauucc uaucuggggu acucagucgc agugggagag      840

uucaguggcg acgauacuga agacuuugug gcuggugucc ccaaagggaa cuuaaccuau      900

ggcuacguua caauccugaa uggaagcgau auacgauccc ucuauaacuu cucuggcgag      960

cagauggcca gcuacuucgg guacgcggug gccgcaacug acguaaaugg agauggucuu     1020

gacgaccugu uggugggcgc uccacuacug auggauagaa cccccgacgg gaggccucaa     1080

gaggucggac ggguguaugu uuaccuccag cacccagccg gcaucgaacc gacacccacc     1140

cugacgcuua cuggucauga ugaguuuggg cguuucggcu caagucugac accuuuggga     1200

gaccucgauc aggacggcua uaacgaugug gcuauugggg ccccauuugg aggugaaacc     1260

cagcaaggcg ucguguucgu auuucccggg ggaccuggcg gucugggguc caagccaagc     1320

cagguuuuac agccccugug ggcagccucu cacacuccgg acuucuuugg cucagcucua     1380

cgcggaggca gagaucucga cgggaaugga uacccugauc ugaucguggg caguuucggu     1440

gucgacaagg cgguggucua uagggggcgg ccaauuguga gcgcauccgc cucucuuaca     1500

aucuuucccg cuauguucaa cccugaggaa cgaucgugca gcuuggaggg aaaucccguu     1560

gccuguauaa accuguccuu uugccucaau gcaucaggca aacauguggc cgacaguauu     1620

gguuucaccg uagagcugca gcuugauugg caaaagcaga aaggcggggu ccgcagagcu     1680

cuguuuuugg ccucuaggca ggcaacgcuc acccagacac uguuaaucca aaacggagcg     1740

cgggaagacu gucgcgagau gaagauuuac cugagaaaug aaagcgaguu cagggauaaa     1800

cuauccccaa uccacaucgc ucucaacuuc ucacuggacc cucaggcccc cguggauagc     1860

cacggccuuc guccagcauu gcauuaucag ucuaaguccc ggauugaaga caaggcccag     1920

auacugcucg auugcgggga ggacaacauc uguguuccgg aucugcaauu agagguguuu     1980

ggagaacaga aucacgucua ccugggcgac aaaaacgcuc uuaauuugac uuuccaugcc     2040

cagaacgugg gugaaggggg agcauacgag gcugagcucc gaguaaccgc cccucccgag     2100

gcggaauaua guggccuggu gagacaccca gguaauuuua gcucucuauc cugcgauuac     2160

uucgccguua accaaucaag gcugcucguc ugcgaccugg gcaaucccau gaaggcuggg     2220

gcaagucuuu ggggaggcuu gcgcuuuaca gugccucauc ugcgggauac uaaaaagacc     2280

auucaguucg acuuucagau cuuaagcaaa aaccucaaua acucgcaguc cgacgugguc     2340

ucuuucagac ugagcguuga ggcccaagcu caggugacac uuaauggggu gucaaagcca     2400

gaagccguac uguuucccgu cagugauugg cacccuaggg accagccgca gaaagaggaa     2460

gauuugggac cagcagugca ccauguuuau gagcucauaa accaaggccc cuccucuauu     2520

agccagggug ugcuggagcu auccuguccu caggcgcugg aagggcagca acuccuguac     2580

gucacccgcg ugacuggacu uaauugcacg acaaaccacc caaucaaucc caagggcuug     2640

gagcuggacc cugaagguuc auuacaucac cagcagaagc gagaggcccc gagccggagu     2700

ucugcuucca gcggccccca aauccucaaa uguccagaag ccgagugcuu ccgucugaga     2760

ugugagcuug ggccucugca ccagcaggaa ucgcagucac uacaacucca uuuuaggguu     2820

ugggcaaaga ccuuccugca gcgcgagcac cagcccuuuu cuuugcagug cgaagcugug     2880

uauaaagccc ugaagaugcc auaccggauu uuaccuagac aacuccccca gaaagagagg     2940

cagguagcaa cugccgucca guggaccaag gcugaaggaa guuauggcgu gccacugugg     3000

aucauuauac uugcgauccu guucggguug cuccugcuag gacugcuuau uuacauccuc     3060

uacaagcugg gcuucuuuaa acgauccuug ccguauggua cagccaugga gaaggcacaa     3120

cugaaaccuc ccgcuaccag cgaugccuga                                      3150


<210>  2020
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ITA5__Homo_sapiens__AAH08786

<400>  2020
augggcagca gaacccccga gagcccccug cacgccgugc agcugagaug gggccccaga       60

agaagacccc cccugcugcc ccugcugcug cugcugcugc cccccccccc cagagugggc      120

ggcuucaacc uggacgccga ggcccccgcc gugcugagcg gcccccccgg cagcuucuuc      180

ggcuucagcg uggaguucua cagacccggc accgacggcg ugagcgugcu ggugggcgcc      240

cccaaggcca acaccagcca gcccggcgug cugcagggcg gcgccgugua ccugugcccc      300

uggggcgcca gccccaccca gugcaccccc aucgaguucg acagcaaggg cagcagacug      360

cuggagagca gccugagcag cagcgagggc gaggagcccg uggaguacaa gagccugcag      420

ugguucggcg ccaccgugag agcccacggc agcagcaucc uggccugcgc cccccuguac      480

agcuggagaa ccgagaagga gccccugagc gaccccgugg gcaccugcua ccugagcacc      540

gacaacuuca ccagaauccu ggaguacgcc cccugcagaa gcgacuucag cugggccgcc      600

ggccagggcu acugccaggg cggcuucagc gccgaguuca ccaagaccgg cagaguggug      660

cugggcggcc ccggcagcua cuucuggcag ggccagaucc ugagcgccac ccaggagcag      720

aucgccgaga gcuacuaccc cgaguaccug aucaaccugg ugcagggcca gcugcagacc      780

agacaggcca gcagcaucua cgacgacagc uaccugggcu acagcguggc cgugggcgag      840

uucagcggcg acgacaccga ggacuucgug gccggcgugc ccaagggcaa ccugaccuac      900

ggcuacguga ccauccugaa cggcagcgac aucagaagcc uguacaacuu cagcggcgag      960

cagauggcca gcuacuucgg cuacgccgug gccgccaccg acgugaacgg cgacggccug     1020

gacgaccugc uggugggcgc cccccugcug auggacagaa cccccgacgg cagaccccag     1080

gaggugggca gaguguacgu guaccugcag caccccgccg gcaucgagcc cacccccacc     1140

cugacccuga ccggccacga cgaguucggc agauucggca gcagccugac cccccugggc     1200

gaccuggacc aggacggcua caacgacgug gccaucggcg cccccuucgg cggcgagacc     1260

cagcagggcg ugguguucgu guuccccggc ggccccggcg gccugggcag caagcccagc     1320

caggugcugc agccccugug ggccgccagc cacacccccg acuucuucgg cagcgcccug     1380

agaggcggca gagaccugga cggcaacggc uaccccgacc ugaucguggg cagcuucggc     1440

guggacaagg ccguggugua cagaggcaga cccaucguga gcgccagcgc cagccugacc     1500

aucuuccccg ccauguucaa ccccgaggag agaagcugca gccuggaggg caaccccgug     1560

gccugcauca accugagcuu cugccugaac gccagcggca agcacguggc cgacagcauc     1620

ggcuucaccg uggagcugca gcuggacugg cagaagcaga agggcggcgu gagaagagcc     1680

cuguuccugg ccagcagaca ggccacccug acccagaccc ugcugaucca gaacggcgcc     1740

agagaggacu gcagagagau gaagaucuac cugagaaacg agagcgaguu cagagacaag     1800

cugagcccca uccacaucgc ccugaacuuc agccuggacc cccaggcccc cguggacagc     1860

cacggccuga gacccgcccu gcacuaccag agcaagagca gaaucgagga caaggcccag     1920

auccugcugg acugcggcga ggacaacauc ugcgugcccg accugcagcu ggagguguuc     1980

ggcgagcaga accacgugua ccugggcgac aagaacgccc ugaaccugac cuuccacgcc     2040

cagaacgugg gcgagggcgg cgccuacgag gccgagcuga gagugaccgc cccccccgag     2100

gccgaguaca gcggccuggu gagacacccc ggcaacuuca gcagccugag cugcgacuac     2160

uucgccguga accagagcag acugcuggug ugcgaccugg gcaaccccau gaaggccggc     2220

gccagccugu ggggcggccu gagauucacc gugccccacc ugagagacac caagaagacc     2280

auccaguucg acuuccagau ccugagcaag aaccugaaca acagccagag cgacguggug     2340

agcuucagac ugagcgugga ggcccaggcc caggugaccc ugaacggcgu gagcaagccc     2400

gaggccgugc uguuccccgu gagcgacugg caccccagag accagcccca gaaggaggag     2460

gaccugggcc ccgccgugca ccacguguac gagcugauca accagggccc cagcagcauc     2520

agccagggcg ugcuggagcu gagcugcccc caggcccugg agggccagca gcugcuguac     2580

gugaccagag ugaccggccu gaacugcacc accaaccacc ccaucaaccc caagggccug     2640

gagcuggacc ccgagggcag ccugcaccac cagcagaaga gagaggcccc cagcagaagc     2700

agcgccagca gcggccccca gauccugaag ugccccgagg ccgagugcuu cagacugaga     2760

ugcgagcugg gcccccugca ccagcaggag agccagagcc ugcagcugca cuucagagug     2820

ugggccaaga ccuuccugca gagagagcac cagcccuuca gccugcagug cgaggccgug     2880

uacaaggccc ugaagaugcc cuacagaauc cugcccagac agcugcccca gaaggagaga     2940

cagguggcca ccgccgugca guggaccaag gccgagggca gcuacggcgu gccccugugg     3000

aucaucaucc uggccauccu guucggccug cugcugcugg gccugcugau cuacauccug     3060

uacaagcugg gcuucuucaa gagaagccug cccuacggca ccgccaugga gaaggcccag     3120

cugaagcccc ccgccaccag cgacgccuga                                      3150


<210>  2021
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ITA5__Homo_sapiens__AAH08786

<400>  2021
augggcagca gaacccccga gucuccccug cacgccgugc agcuccggug ggggccgcgc       60

agacggcccc cucugcuucc ccugcuccug cuucugcucc cucccccucc gcgcgucgga      120

ggcuucaacc uggacgcuga agcccccgcg guucuguccg ggccucccgg cagcuuuuuc      180

ggcuuuuccg uggaguucua cagaccuggg acagauggag ugucuguccu cgugggcgcu      240

cccaaggcca auacgagcca accgggcguu cugcaagggg gagccgugua ucuuugcccu      300

uggggcgcuu cccccaccca guguacaccu aucgaauuug acucuaaagg gagccggcug      360

cucgagucca gccugucuuc cagcgaagga gaggagcccg ucgaauacaa gucucuucag      420

ugguucggcg ccaccgugcg cgcucauggg uccagcauuc uggccugcgc gccccucuau      480

ucuuggagaa cagagaaaga accucugucc gauccgguug gaaccuguua ccugagcaca      540

gacaacuuua cccggauccu cgaguaugcc cccugccgcu ccgauuucuc uugggcugcc      600

ggccagggcu acugucaagg gggauuuagc gcugaguuca cgaagaccgg cagagugguc      660

cuugggggac cuggcuccua uuuuuggcag gggcagauuc ugagcgccac acaggaacag      720

aucgcggagu cuuacuaccc cgaauaucug auuaaucucg ugcagggaca gcugcaaacc      780

cggcaggccu ccagcaucua cgacgauucu uaucuuggcu acagcguggc ugucggcgag      840

uucuccgggg acgauacaga agacuuuguu gccggagugc cuaaaggcaa ccugaccuau      900

ggguacguga cgauccucaa uggaucugau auucgcagcc uguauaacuu cuccggcgag      960

cagauggcua gcuacuucgg guacgccguc gccgcuacag acgugaaugg cgauggacug     1020

gacgaccucc ugguuggcgc gccccuucug auggauagaa ccccggacgg gcggccucaa     1080

gaggugggac gcgucuaugu guaccuccag caccccgccg gcaucgaacc uacacccacc     1140

cugacccuua cagggcauga ugaguuugga agauucggau cuucccugac gccucucggg     1200

gaccuggauc aggacggcua uaacgauguu gcuauuggag cccccuuugg cggggaaacc     1260

cagcaaggag uggucuucgu guuuccgggc gggccuggag gccuggggag caagcccucu     1320

cagguccucc agccccugug ggccgcuucc cacacaccug acuucuuugg cagcgcccuu     1380

cggggaggca gagaucugga cgggaaugga uacccggauc ucaucguggg cuccuucggg     1440

guugacaagg cgguggucua ucgcggacgg cccauugugu cugcuagcgc cucccugacc     1500

aucuuuccug ccauguucaa ccccgaggaa agaucuugca gccuggaggg caauccuguu     1560

gcuuguauua accuuuccuu uugccucaau gccagcggga aacauguggc ugacucuauc     1620

ggcuucacag ucgagcugca gcuggauugg caaaagcaga aaggaggcgu gcgccgggcc     1680

cucuuucugg cguccagaca ggccacccuu acgcagacac ugcucaucca aaacggggcu     1740

cgcgaagacu gucgggagau gaagauuuac cugagaaaug aaagcgaguu ccgcgauaaa     1800

cugucuccca uccacauugc ccuuaacuuc ucccucgacc cucaggcucc cguggauagc     1860

cacggacugc ggccggcccu gcauuaucag ucuaagagca gaaucgaaga caaggcgcag     1920

auucuccugg auugcggcga ggacaacauc uguguuccug aucuucaacu ggaggucuuu     1980

ggggaacaga aucacgugua ccucggagac aaaaacgccc ugaaucugac cuuccaugcu     2040

cagaacgugg gcgagggcgg ggccuacgaa gcugagcuuc gcgucaccgc ucccccugag     2100

gccgaauauu ccggacucgu gcggcacccc ggcaauuuua gcucucuguc cugcgauuac     2160

uucgccguua accaaagcag acugcucgug ugcgaccugg ggaauccgau gaaggcggga     2220

gccucccuuu ggggcgggcu gcgguuuaca gucccucacc uccgcgauac caaaaagaca     2280

auccaguucg acuuucagau ucugucuaaa aaccugaaua acagccaguc cgacgugguu     2340

ucuuucagac uuagcgugga ggcucaagcc caggucacgc ucaauggagu guccaagccc     2400

gaagccguuc uguuuccugu gucugauugg cauccccggg accagcccca gaaagaggaa     2460

gaucugggcc cugcugucca ccauguguau gagcucauca accaaggccc gagcuccauu     2520

agccaggggg ugcuggagcu uucuuguccc caggcccugg aaggacagca acuccuguac     2580

gucaccagag uuacaggccu gaauugcacc acaaaccacc cuaucaaucc caaggggcuu     2640

gagcuggacc cugaaggauc ccuccaucac cagcagaagc gcgaggcgcc cagccggucu     2700

uccgcuagcu cuggcccuca aauucugaaa uguccggaag ccgagugcuu cagacuccgc     2760

ugugagcugg ggccccuuca ccagcaggaa ucccagagcc ugcaacucca uuuuagagug     2820

ugggccaaga ccuuccugca gcgggagcac cagccuuuuu cccugcagug cgaagcugug     2880

uauaaagccc uuaagaugcc cuaccgcauc cugccuagac aacuccccca gaaagagcgg     2940

caggucgcga cggcugugca guggaccaag gccgaaggaa gcuauggcgu uccgcugugg     3000

aucauuaucc ucgccauucu guucggccuu cugcuccugg ggcugcuuau cuacauucug     3060

uacaagcucg gauucuuuaa acgcucucug ccuuauggca cagcuaugga gaaggcccaa     3120

cucaaaccuc ccgcuaccag cgaugccuga                                      3150


<210>  2022
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ITB1__Homo_sapiens__P05556

<400>  2022

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  2023
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ITB1__Homo_sapiens__AAH20057

<400>  2023
augaauuuac aaccaauuuu cuggauugga cugaucaguu caguuugcug uguguuugcu       60

caaacagaug aaaauagaug uuuaaaagca aaugccaaau cauguggaga auguauacaa      120

gcagggccaa auugugggug gugcacaaau ucaacauuuu uacaggaagg aaugccuacu      180

ucugcacgau gugaugauuu agaagccuua aaaaagaagg guugcccucc agaugacaua      240

gaaaauccca gaggcuccaa agauauaaag aaaaauaaaa auguaaccaa ccguagcaaa      300

ggaacagcag agaagcucaa gccagaggau auuacucaga uccaaccaca gcaguugguu      360

uugcgauuaa gaucagggga gccacagaca uuuacauuaa aauucaagag agcugaagac      420

uaucccauug accucuacua ccuuauggac cugucuuacu caaugaaaga cgauuuggag      480

aauguaaaaa gucuuggaac agaucugaug aaugaaauga ggaggauuac uucggacuuc      540

agaauuggau uuggcucauu uguggaaaag acugugaugc cuuacauuag cacaacacca      600

gcuaagcuca ggaacccuug cacaagugaa cagaacugca ccagcccauu uagcuacaaa      660

aaugugcuca gucuuacuaa uaaaggagaa guauuuaaug aacuuguugg aaaacagcgc      720

auaucuggaa auuuggauuc uccagaaggu gguuucgaug ccaucaugca aguugcaguu      780

uguggaucac ugauuggcug gaggaauguu acacggcugc ugguguuuuc cacagaugcc      840

ggguuucacu uugcuggaga ugggaaacuu gguggcauug uuuuaccaaa ugauggacaa      900

ugucaccugg aaaauaauau guacacaaug agccauuauu augauuaucc uucuauugcu      960

caccuugucc agaaacugag ugaaaauaau auucagacaa uuuuugcagu uacugaagaa     1020

uuucagccug uuuacaagga gcugaaaaac uugaucccua agucagcagu aggaacauua     1080

ucugcaaauu cuagcaaugu aauucaguug aucauugaug cauacaauuc ccuuuccuca     1140

gaagucauuu uggaaaacgg caaauuguca gaaggaguaa caauaaguua caaaucuuac     1200

ugcaagaacg gggugaaugg aacaggggaa aauggaagaa aauguuccaa uauuuccauu     1260

ggagaugagg uucaauuuga aauuagcaua acuucaaaua aguguccaaa aaaggauucu     1320

gacagcuuua aaauuaggcc ucugggcuuu acggaggaag uagagguuau ucuucaguac     1380

aucugugaau gugaaugcca aagcgaaggc aucccugaaa gucccaagug ucaugaagga     1440

aaugggacau uugagugugg cgcgugcagg ugcaaugaag ggcguguugg uagacauugu     1500

gaaugcagca cagaugaagu uaacagugaa gacauggaug cuuacugcag gaaagaaaac     1560

aguucagaaa ucugcaguaa caauggagag ugcgucugcg gacagugugu uuguaggaag     1620

agggauaaua caaaugaaau uuauucuggc aaauucugcg agugugauaa uuucaacugu     1680

gauagaucca auggcuuaau uuguggagga aaugguguuu gcaagugucg ugugugugag     1740

ugcaacccca acuacacugg cagugcaugu gacuguucuu uggauacuag uacuugugaa     1800

gccagcaacg gacagaucug caauggccgg ggcaucugug aguguggugu cuguaagugu     1860

acagauccga aguuucaagg gcaaacgugu gagauguguc agaccugccu uggugucugu     1920

gcugagcaua aagaaugugu ucagugcaga gccuucaaua aaggagaaaa gaaagacaca     1980

ugcacacagg aauguuccua uuuuaacauu accaagguag aaagucggga caaauuaccc     2040

cagccggucc aaccugaucc ugugucccau uguaaggaga aggauguuga cgacuguugg     2100

uucuauuuua cguauucagu gaaugggaac aacgagguca ugguucaugu uguggagaau     2160

ccagaguguc ccacuggucc agacaucauu ccaauuguag cugguguggu ugcuggaauu     2220

guucuuauug gccuugcauu acugcugaua uggaagcuuu uaaugauaau ucaugacaga     2280

agggaguuug cuaaauuuga aaaggagaaa augaaugcca aaugggacac gggugaaaau     2340

ccuauuuaua agagugccgu aacaacugug gucaauccga aguaugaggg aaaauga        2397


<210>  2024
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ITB1__Homo_sapiens__AAH20057

<400>  2024
augaaccugc agcccaucuu cuggaucggc cucaucagcu ccgugugcug cgucuucgcc       60

cagaccgacg agaaccgcug ccugaaggcc aacgccaaga gcugcgggga gugcauccag      120

gcgggcccga acugcgggug gugcaccaac uccacguucc ugcaggaggg caugcccacc      180

agcgcccggu gcgacgaccu cgaggcccug aagaagaagg ggugcccgcc cgacgacauc      240

gagaaccccc gcggcuccaa ggacaucaag aagaacaaga acgugaccaa ccggagcaag      300

ggcaccgccg agaagcugaa gcccgaggac aucacgcaga uccagcccca gcagcucgug      360

cugcgccugc gguccgggga gccccagacc uucacccuca aguucaagcg cgcggaggac      420

uacccgaucg accuguacua ccugauggac cucagcuacu ccaugaagga cgaccuggag      480

aacgucaaga gccugggcac cgaccucaug aacgagaugc ggcgcaucac guccgacuuc      540

cggaucgggu ucggcagcuu cguggagaag accgugaugc ccuacaucuc caccaccccc      600

gccaagcugc gcaaccccug cacgagcgag cagaacugca ccuccccguu cagcuacaag      660

aacguccugu cccucaccaa caagggggag guguucaacg agcugguggg caagcagcgg      720

aucagcggca accuggacuc ccccgagggc ggguucgacg ccaucaugca ggucgccgug      780

ugcgggagcc ucaucggcug gcgcaacgug acccggcugc uggucuucag cacggacgcg      840

ggcuuccacu ucgccgggga cggcaagcuc gggggcaucg ugcugcccaa cgacgggcag      900

ugccaccugg agaacaacau guacaccaug ucccacuacu acgacuaccc cagcaucgcc      960

caccucgugc agaagcuguc cgagaacaac auccagacca ucuucgccgu caccgaggag     1020

uuccagccgg uguacaagga gcugaagaac cucaucccca agagcgccgu gggcacgcug     1080

uccgcgaaca gcuccaacgu cauccagcug aucaucgacg ccuacaacag ccucuccagc     1140

gaggugaucc uggagaacgg caagcugucc gaggggguga ccaucagcua caaguccuac     1200

ugcaagaacg gcgucaacgg gaccggcgag aacgggcgca agugcagcaa caucuccauc     1260

ggcgacgagg ugcaguucga gaucagcauc accuccaaca agugccccaa gaaggacagc     1320

gacuccuuca agauccggcc ccucggcuuc acggaggagg uggaggucau ccugcaguac     1380

aucugcgagu gcgagugcca gagcgagggg aucccggaga gccccaagug ccacgagggc     1440

aacgggaccu ucgagugcgg cgccugccgc ugcaacgagg ggcggguggg ccgccacugc     1500

gagugcucca ccgacgaggu caacagcgag gacauggacg ccuacugccg gaaggagaac     1560

uccagcgaga ucugcuccaa caacggcgag ugcgugugcg ggcagugcgu gugccgcaag     1620

cgggacaaca ccaacgagau cuacagcggc aaguucugcg agugcgacaa cuucaacugc     1680

gaccgcucca acgggcugau cugcggcggc aacggggucu gcaagugccg cgugugcgag     1740

ugcaacccca acuacacggg cagcgccugc gacugcuccc ucgacaccag cacgugcgag     1800

gcguccaacg ggcagaucug caacggccgg gggaucugcg agugcggcgu gugcaagugc     1860

accgacccca aguuccaggg ccagaccugc gagaugugcc agaccugccu gggggucugc     1920

gccgagcaca aggagugcgu gcagugccgc gccuucaaca agggcgagaa gaaggacacg     1980

ugcacccagg agugcagcua cuucaacauc accaaggugg agucccggga caagcugccg     2040

cagcccgucc agcccgaccc cgugagccac ugcaaggaga aggacgugga cgacugcugg     2100

uucuacuuca ccuacuccgu caacgggaac aacgagguga uggugcacgu cguggagaac     2160

ccggagugcc ccaccggccc cgacaucauc ccgaucgugg ccggggucgu ggccggcauc     2220

gugcucaucg gccuggcgcu gcuccugauc uggaagcugc ucaugaucau ccacgaccgc     2280

cgggaguucg ccaaguucga gaaggagaag augaacgcca agugggacac cggggagaac     2340

cccaucuaca agagcgccgu caccacggug gugaacccca aguacgaggg caaguga        2397


<210>  2025
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ITB1__Homo_sapiens__AAH20057

<400>  2025
augaaccucc agcccaucuu cuggaucggc cucaucuccu ccgucugcug cgucuucgcc       60

cagaccgacg agaaccgcug ccucaaggcc aacgccaagu ccugcggcga gugcauccag      120

gccggcccca acugcggcug gugcaccaac uccaccuucc uccaggaggg caugcccacc      180

uccgcccgcu gcgacgaccu cgaggcccuc aagaagaagg gcugcccccc cgacgacauc      240

gagaaccccc gcggcuccaa ggacaucaag aagaacaaga acgucaccaa ccgcuccaag      300

ggcaccgccg agaagcucaa gcccgaggac aucacccaga uccagcccca gcagcucguc      360

cuccgccucc gcuccggcga gccccagacc uucacccuca aguucaagcg cgccgaggac      420

uaccccaucg accucuacua ccucauggac cucuccuacu ccaugaagga cgaccucgag      480

aacgucaagu cccucggcac cgaccucaug aacgagaugc gccgcaucac cuccgacuuc      540

cgcaucggcu ucggcuccuu cgucgagaag accgucaugc ccuacaucuc caccaccccc      600

gccaagcucc gcaaccccug caccuccgag cagaacugca ccucccccuu cuccuacaag      660

aacguccucu cccucaccaa caagggcgag gucuucaacg agcucgucgg caagcagcgc      720

aucuccggca accucgacuc ccccgagggc ggcuucgacg ccaucaugca ggucgccguc      780

ugcggcuccc ucaucggcug gcgcaacguc acccgccucc ucgucuucuc caccgacgcc      840

ggcuuccacu ucgccggcga cggcaagcuc ggcggcaucg uccuccccaa cgacggccag      900

ugccaccucg agaacaacau guacaccaug ucccacuacu acgacuaccc cuccaucgcc      960

caccucgucc agaagcucuc cgagaacaac auccagacca ucuucgccgu caccgaggag     1020

uuccagcccg ucuacaagga gcucaagaac cucaucccca aguccgccgu cggcacccuc     1080

uccgccaacu ccuccaacgu cauccagcuc aucaucgacg ccuacaacuc ccucuccucc     1140

gaggucaucc ucgagaacgg caagcucucc gagggcguca ccaucuccua caaguccuac     1200

ugcaagaacg gcgucaacgg caccggcgag aacggccgca agugcuccaa caucuccauc     1260

ggcgacgagg uccaguucga gaucuccauc accuccaaca agugccccaa gaaggacucc     1320

gacuccuuca agauccgccc ccucggcuuc accgaggagg ucgaggucau ccuccaguac     1380

aucugcgagu gcgagugcca guccgagggc auccccgagu cccccaagug ccacgagggc     1440

aacggcaccu ucgagugcgg cgccugccgc ugcaacgagg gccgcgucgg ccgccacugc     1500

gagugcucca ccgacgaggu caacuccgag gacauggacg ccuacugccg caaggagaac     1560

uccuccgaga ucugcuccaa caacggcgag ugcgucugcg gccagugcgu cugccgcaag     1620

cgcgacaaca ccaacgagau cuacuccggc aaguucugcg agugcgacaa cuucaacugc     1680

gaccgcucca acggccucau cugcggcggc aacggcgucu gcaagugccg cgucugcgag     1740

ugcaacccca acuacaccgg cuccgccugc gacugcuccc ucgacaccuc caccugcgag     1800

gccuccaacg gccagaucug caacggccgc ggcaucugcg agugcggcgu cugcaagugc     1860

accgacccca aguuccaggg ccagaccugc gagaugugcc agaccugccu cggcgucugc     1920

gccgagcaca aggagugcgu ccagugccgc gccuucaaca agggcgagaa gaaggacacc     1980

ugcacccagg agugcuccua cuucaacauc accaaggucg agucccgcga caagcucccc     2040

cagcccgucc agcccgaccc cgucucccac ugcaaggaga aggacgucga cgacugcugg     2100

uucuacuuca ccuacuccgu caacggcaac aacgagguca ugguccacgu cgucgagaac     2160

cccgagugcc ccaccggccc cgacaucauc cccaucgucg ccggcgucgu cgccggcauc     2220

guccucaucg gccucgcccu ccuccucauc uggaagcucc ucaugaucau ccacgaccgc     2280

cgcgaguucg ccaaguucga gaaggagaag augaacgcca agugggacac cggcgagaac     2340

cccaucuaca aguccgccgu caccaccguc gucaacccca aguacgaggg caaguga        2397


<210>  2026
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ITB1__Homo_sapiens__AAH20057

<400>  2026
augaaccugc agcccaucuu cuggauuggc cucauaagcu ccgugugcug ugucuuugcc       60

caaaccgacg agaauagaug ccuuaaggcu aacgcaaaau cuugugggga augcauccag      120

gccggaccua auugugguug gugcacaaac ucaacuuucc ugcaggaggg caugccaacg      180

agugcgaggu gugaugacuu ggaggcuuua aagaaaaagg ggugcccgcc cgaugacauu      240

gaaaauccuc ggggaagcaa agauaucaag aagaacaaaa auguuaccaa ccgcuccaag      300

ggcacagccg aaaaacugaa gccagaggac auuacucaga uccaacccca gcagcuagug      360

cuccgacugc guucugguga gccucagacc uuuacacuua aauucaagag agcagaagau      420

uacccaauag accuguauua cuugauggau cucucguauu caaugaagga cgaucuggag      480

aauguaaaaa gccuggggac cgaccucaug aacgaaauga ggcggaucac aagugauuuu      540

cgcauuggau ucggcuccuu uguggagaag acugucaugc ccuacaucuc uaccacgccu      600

gccaaauuaa gaaauccaug uacuagcgag caaaacugca ccuccccguu cucauauaag      660

aaugugcuga gucuuacaaa caaaggcgaa guuuuuaaug aguugguggg gaagcagagg      720

auuagcggaa accuggacuc ucccgaaggu ggcuucgacg cuaucaugca ggucgcagug      780

uguggguccc uaauaggaug gcggaacgua acucgccucc ugguuuuuag caccgaugcc      840

ggcuuccacu uugcugguga cgggaaacuu ggaggcauug ugcugccuaa ugauggccag      900

ugccauuugg agaacaauau guacacaaug agccacuauu acgacuaccc aaguaucgcc      960

caucucgucc aaaagcuguc ugaaaacaau auucagacca ucuucgcggu gacggaggag     1020

uuccagcccg uguauaagga acugaaaaac uuaaucccua aguccgcagu cgggacucuc     1080

agcgccaauu cgucuaacgu uauucaacuu auaaucgaug cuuacaauuc ccugucaagu     1140

gaggugauuu uggaaaacgg aaaacuaagc gaggguguaa caaucuccua uaagucuuac     1200

ugcaaaaaug gcgugaacgg gaccggagaa aauggccgaa aguguagcaa cauaucaauu     1260

ggugacgagg uccaguuuga gaucaguauc acuuccaaua agugccccaa aaaggauagc     1320

gacucuuuca aaauuagacc acugggguuu acagaagagg uggaaguuau ccuccaguau     1380

auuugugagu gcgaauguca gucagagggc auaccggaga guccuaagug ccacgaagga     1440

aacggcaccu ucgagugugg ggccuguagg ugcaacgaag gacggguggg ucgucauugc     1500

gaguguagca cggaugaggu caauuccgaa gacauggaug cauacugccg caaagagaac     1560

ucuucggaaa ucugcagcaa uaacggcgag ugugugugcg ggcaaugugu augcagaaag     1620

agggacaaua ccaacgaaau uuauuccgga aaguuuugug agugcgacaa uuucaacugu     1680

gaucggucaa auggccugau cugcgguggg aacggcguuu guaaaugccg agugugugag     1740

ugcaauccca acuacacagg aagugcuugc gacuguucuc uugauacuuc aaccugcgaa     1800

gccuccaaug gccagaucug uaacgggcgc ggaauuugcg aguguggugu cugcaagugu     1860

acagacccaa aauuucaggg ccagacuugc gaaauguguc aaaccugccu gggggugugu     1920

gcggagcaca aggaaugcgu ccagugcaga gccuucaaua aaggagagaa gaaggauaca     1980

uguacccagg agugcucaua cuuuaacaua acuaaagugg aaagcaggga caaguugccu     2040

cagcccguuc aaccagaucc cgugucucac uguaaagaga aggacguaga ugacugcugg     2100

uucuauuuua cguacuccgu caacggcaau aacgaaguga ugguucaugu ggucgagaau     2160

ccugaauguc caacaggucc ggauaucauu cccaucgugg cagggguagu ggcuggcauu     2220

guucucaucg gacuggccuu acugcuaaua uggaaacucc ugaugaucau ucacgaccgg     2280

cgcgaguucg cuaaguuuga gaaagaaaag augaacgcca agugggauac cggcgagaau     2340

ccuaucuaua aaagugcagu cacuaccgug gugaacccaa aguacgaagg gaaauga        2397


<210>  2027
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ITB1__Homo_sapiens__AAH20057

<400>  2027
augaaccugc agcccaucuu cuggaucggc cugaucagca gcgugugcug cguguucgcc       60

cagaccgacg agaacagaug ccugaaggcc aacgccaaga gcugcggcga gugcauccag      120

gccggcccca acugcggcug gugcaccaac agcaccuucc ugcaggaggg caugcccacc      180

agcgccagau gcgacgaccu ggaggcccug aagaagaagg gcugcccccc cgacgacauc      240

gagaacccca gaggcagcaa ggacaucaag aagaacaaga acgugaccaa cagaagcaag      300

ggcaccgccg agaagcugaa gcccgaggac aucacccaga uccagcccca gcagcuggug      360

cugagacuga gaagcggcga gccccagacc uucacccuga aguucaagag agccgaggac      420

uaccccaucg accuguacua ccugauggac cugagcuaca gcaugaagga cgaccuggag      480

aacgugaaga gccugggcac cgaccugaug aacgagauga gaagaaucac cagcgacuuc      540

agaaucggcu ucggcagcuu cguggagaag accgugaugc ccuacaucag caccaccccc      600

gccaagcuga gaaaccccug caccagcgag cagaacugca ccagccccuu cagcuacaag      660

aacgugcuga gccugaccaa caagggcgag guguucaacg agcugguggg caagcagaga      720

aucagcggca accuggacag ccccgagggc ggcuucgacg ccaucaugca gguggccgug      780

ugcggcagcc ugaucggcug gagaaacgug accagacugc ugguguucag caccgacgcc      840

ggcuuccacu ucgccggcga cggcaagcug ggcggcaucg ugcugcccaa cgacggccag      900

ugccaccugg agaacaacau guacaccaug agccacuacu acgacuaccc cagcaucgcc      960

caccuggugc agaagcugag cgagaacaac auccagacca ucuucgccgu gaccgaggag     1020

uuccagcccg uguacaagga gcugaagaac cugaucccca agagcgccgu gggcacccug     1080

agcgccaaca gcagcaacgu gauccagcug aucaucgacg ccuacaacag ccugagcagc     1140

gaggugaucc uggagaacgg caagcugagc gagggcguga ccaucagcua caagagcuac     1200

ugcaagaacg gcgugaacgg caccggcgag aacggcagaa agugcagcaa caucagcauc     1260

ggcgacgagg ugcaguucga gaucagcauc accagcaaca agugccccaa gaaggacagc     1320

gacagcuuca agaucagacc ccugggcuuc accgaggagg uggaggugau ccugcaguac     1380

aucugcgagu gcgagugcca gagcgagggc auccccgaga gccccaagug ccacgagggc     1440

aacggcaccu ucgagugcgg cgccugcaga ugcaacgagg gcagaguggg cagacacugc     1500

gagugcagca ccgacgaggu gaacagcgag gacauggacg ccuacugcag aaaggagaac     1560

agcagcgaga ucugcagcaa caacggcgag ugcgugugcg gccagugcgu gugcagaaag     1620

agagacaaca ccaacgagau cuacagcggc aaguucugcg agugcgacaa cuucaacugc     1680

gacagaagca acggccugau cugcggcggc aacggcgugu gcaagugcag agugugcgag     1740

ugcaacccca acuacaccgg cagcgccugc gacugcagcc uggacaccag caccugcgag     1800

gccagcaacg gccagaucug caacggcaga ggcaucugcg agugcggcgu gugcaagugc     1860

accgacccca aguuccaggg ccagaccugc gagaugugcc agaccugccu gggcgugugc     1920

gccgagcaca aggagugcgu gcagugcaga gccuucaaca agggcgagaa gaaggacacc     1980

ugcacccagg agugcagcua cuucaacauc accaaggugg agagcagaga caagcugccc     2040

cagcccgugc agcccgaccc cgugagccac ugcaaggaga aggacgugga cgacugcugg     2100

uucuacuuca ccuacagcgu gaacggcaac aacgagguga uggugcacgu gguggagaac     2160

cccgagugcc ccaccggccc cgacaucauc cccaucgugg ccggcguggu ggccggcauc     2220

gugcugaucg gccuggcccu gcugcugauc uggaagcugc ugaugaucau ccacgacaga     2280

agagaguucg ccaaguucga gaaggagaag augaacgcca agugggacac cggcgagaac     2340

cccaucuaca agagcgccgu gaccaccgug gugaacccca aguacgaggg caaguga        2397


<210>  2028
<211>  2397
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ITB1__Homo_sapiens__AAH20057

<400>  2028
augaaccugc agcccaucuu cuggauuggc cucaucagcu ccgugugcug ugucuuugcc       60

caaaccgacg agaauagaug ccugaaggcu aacgccaaau cuugugggga augcauucag      120

gcgggaccua auuguggcug gugcacaaac agcacguucc uucaggaggg gaugccgacc      180

uccgcucggu gugaugaccu ggaagcccuc aagaaaaagg gauguccccc ugaugacauc      240

gagaaucccc gcggcucuaa agauauuaag aagaacaaaa auguuacaaa cagaagcaag      300

gggaccgccg aaaaacugaa gccugaggac aucacacaga uccaacccca gcagcuugug      360

cugcggcucc gcuccggaga gccucagacc uuuacacuga aauucaagag agcugaagau      420

uacccgauug accuguauua ccucauggau cugucuuaua gcaugaagga cgaucuugag      480

aaugugaaau cccugggcac cgaccucaug aacgaaaugc ggcgcaucac gagcgauuuu      540

agaauuggcu ucgggucuuu ugucgagaag accgugaugc ccuacaucuc cacaaccccu      600

gccaaacugc ggaaucccug cacaagcgag caaaacugca ccucuccuuu cuccuauaag      660

aauguucuua gccugacgaa caaaggagaa guguuuaaug agcucgucgg caagcagcgc      720

auuucuggga accuggacuc ccccgaagga ggcuucgacg cuaucaugca aguggccguu      780

ugugggagcc ugauuggaug gagaaacgug acacggcucc uggucuuuuc caccgaugcg      840

ggcuuccacu uugccggcga cgggaaacuu ggaggcaucg ugcugccgaa ugaugggcag      900

ugccaucucg agaacaauau guacacaaug ucucacuauu acgacuaccc uagcaucgcu      960

caucuggugc agaaacuuuc cgaaaacaau auucagacca ucuucgccgu caccgaggag     1020

uuccagcccg uuuauaagga acugaagaac cucauuccua agagcgcugu gggaacacug     1080

ucugccaauu ccagcaacgu gauccaacug auuaucgaug cguacaauuc ucucagcucc     1140

gaggucaucc uggaaaacgg caaacuuucu gaggggguga cgauuagcua uaaguccuac     1200

ugcaaaaaug gaguuaacgg caccggcgaa aaugggcgca aguguagcaa caucucuauu     1260

ggagacgagg ugcaguuuga gaucuccauu acaagcaaua agugccccaa aaaggauucu     1320

gacuccuuca aaaucagacc ccugggcuuu accgaagagg ucgaagugau ccuccaguau     1380

auuugugagu gcgaauguca gagcgagggg aucccugagu ccccgaagug ccacgaagga     1440

aacggcacau ucgagugugg ggccugccgg uguaacgaag gccgcguugg aagacauugc     1500

gaguguucua ccgaugaggu gaauagcgaa gacauggaug cuuacugccg gaaagagaac     1560

uccucugaaa uuugcagcaa uaacggcgag ugugucugcg ggcaaugugu gugcagaaag     1620

cgcgacaaua cgaacgaaau cuauuccgga aaguuuugug agugcgacaa uuucaacugu     1680

gaucggagca auggccugau uugcggggga aacggcgucu guaaaugcag agugugugag     1740

ugcaauccca acuacacagg gucugccugc gacuguuccc uugauaccuc uaccugcgaa     1800

gcuagcaaug gccagaucug uaacggacgc ggcauuugcg aguguggggu uugcaagugu     1860

acagacccua aauuucaggg acagaccugc gaaauguguc aaacaugccu gggcgugugu     1920

gccgagcaca aggaaugcgu ccagugccgg gccuucaaua aaggggagaa gaaggauacg     1980

uguacccagg agugcuccua cuuuaacauc acaaaagugg aaagcagaga caagcucccc     2040

cagccuguuc aacccgaucc ggugucucac uguaaagaga aggacgucga ugacugcugg     2100

uucuauuuua ccuacagcgu gaacggaaau aacgaaguga ugguucaugu cguggagaau     2160

ccugaauguc ccacaggccc ugauaucauu cccaucgugg cuggggucgu ggcgggcauu     2220

guucugaucg gacuggcccu ccugcuuauu uggaaacugc ucaugaucau ccacgaccgc     2280

cgggaguucg cuaaguuuga gaaagaaaag augaacgcca agugggauac cggcgagaau     2340

ccuauuuaua aauccgccgu gacgaccguc gugaacccca aguacgaagg gaaauga        2397


<210>  2029
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ITB6__Homo_sapiens__P18564

<400>  2029

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  2030
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ITB6__Homo_sapiens__AAA36122

<400>  2030
auggggauug aacugcuuug ccuguucuuu cuauuucuag gaaggaauga ucacguacaa       60

gguggcugug cccugggagg ugcagaaacc ugugaagacu gccugcuuau uggaccucag      120

ugugccuggu gugcucagga gaauuuuacu cauccaucug gaguuggcga aaggugugau      180

accccagcaa accuuuuagc uaaaggaugu caauuaaacu ucaucgaaaa cccugucucc      240

caaguagaaa uacuuaaaaa uaagccucuc aguguaggca gacagaaaaa uaguucugac      300

auuguucaga uugcgccuca aagcuugauc cuuaaguuga gaccaggugg ugcgcagacu      360

cugcaggugc auguccgcca gacugaggac uacccggugg auuuguauua ccucauggac      420

cucuccgccu ccauggauga cgaccucaac acaauaaagg agcugggcuc ccggcuuucc      480

aaagagaugu cuaaauuaac cagcaacuuu agacugggcu ucggaucuuu uguggaaaaa      540

ccuguauccc cuuucgugaa aacaacacca gaagaaauug ccaacccuug caguaguauu      600

ccauacuucu guuuaccuac auuuggauuc aagcacauuu ugccauugac aaaugaugcu      660

gaaagauuca augaaauugu gaagaaucag aaaauuucug cuaauauuga cacacccgaa      720

gguggauuug augcaauuau gcaagcugcu guguguaagg aaaaaauugg cuggcggaau      780

gacucccucc accuccuggu cuuugugagu gaugcugauu cucauuuugg aauggacagc      840

aaacuagcag gcaucgucau uccuaaugac gggcucuguc acuuggacag caagaaugaa      900

uacuccaugu caacugucuu ggaauaucca acaauuggac aacucauuga uaaacuggua      960

caaaacaacg uguuauugau cuucgcugua acccaagaac aaguucauuu auaugagaau     1020

uacgcaaaac uuauuccugg agcuacagua ggucuacuuc agaaggacuc cggaaacauu     1080

cuccagcuga ucaucucagc uuaugaagaa cugcggucug agguggaacu ggaaguauua     1140

ggagacacug aaggacucaa cuugucauuu acagccaucu guaacaacgg uacccucuuc     1200

caacaccaaa agaaaugcuc ucacaugaaa gugggagaca cagcuuccuu cagcgugacu     1260

gugaauaucc cacacugcga gagaagaagc aggcacauua ucauaaagcc uguggggcug     1320

ggggaugccc uggaauuacu ugucagccca gaaugcaacu gcgacuguca gaaagaagug     1380

gaagugaaca gcuccaaaug ucaccacggg aacggcucuu uccagugugg ggugugugcc     1440

ugccacccug gccacauggg gccucgcugu gaguguggcg aggacaugcu gagcacagau     1500

uccugcaagg aggccccaga ucaucccucc ugcagcggaa ggggugacug cuacuguggg     1560

caguguaucu gccacuuguc ucccuaugga aacauuuaug ggccuuauug ccagugugac     1620

aauuucuccu gcgugagaca caaagggcug cucugcggag guaacggcga cugugacugu     1680

ggugaaugug ugugcaggag cggcuggacu ggcgaguacu gcaacugcac caccagcacg     1740

gacuccugcg ucucugaaga uggagugcuc ugcagcgggc gcggggacug uguuuguggc     1800

aaguguguuu gcacaaaccc uggagccuca ggaccaaccu gugaacgaug uccuaccugu     1860

ggugaccccu guaacucuaa acggagcugc auugagugcc accugucagc agcuggccaa     1920

gcccgagaag aaugugugga caagugcaaa cuagcuggug cgaccaucag ugaagaagaa     1980

gauuucucaa aggaugguuc uguuuccugc ucucugcaag gagaaaauga augucuuauu     2040

acauuccuaa uaacuacaga uaaugagggg aaaaccauca uucacagcau caaugaaaaa     2100

gauuguccga agccuccaaa cauucccaug aucauguuag ggguuucccu ggcuauucuu     2160

cucaucgggg uuguccuacu gugcaucugg aagcuacugg ugucauuuca ugaucguaaa     2220

gaaguugcca aauuugaagc agaacgauca aaagccaagu ggcaaacggg aaccaaucca     2280

cucuacagag gauccacaag uacuuuuaaa aauguaacuu auaaacacag ggaaaaacaa     2340

aagguagacc uuuccacaga uugcuag                                         2367


<210>  2031
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ITB6__Homo_sapiens__AAA36122

<400>  2031
augggcaucg agcugcucug ccuguucuuc cuguuccucg ggcgcaacga ccacgugcag       60

ggcgggugcg cccugggcgg ggccgagacc ugcgaggacu gccugcucau cggcccccag      120

ugcgcguggu gcgcccagga gaacuucacc cacccgagcg gcgucgggga gcggugcgac      180

acgcccgcca accugcuggc caagggcugc cagcucaacu ucaucgagaa ccccgugucc      240

cagguggaga uccugaagaa caagccccug agcgucgggc gccagaagaa cuccagcgac      300

aucgugcaga ucgccccgca gucccucauc cugaagcugc ggcccggcgg ggcgcagacc      360

cuccaggugc acguccgcca gaccgaggac uaccccgugg accuguacua ccugauggac      420

cucagcgccu ccauggacga cgaccugaac accaucaagg agcugggcag ccggcucucc      480

aaggagauga gcaagcugac guccaacuuc cgccugggcu ucgggagcuu cguggagaag      540

cccgucuccc cguucgugaa gaccaccccc gaggagaucg ccaaccccug cagcuccauc      600

cccuacuucu gccucccgac cuucggcuuc aagcacaucc ugccccugac gaacgacgcc      660

gagcgguuca acgagaucgu gaagaaccag aagaucagcg cgaacaucga cacccccgag      720

ggcggguucg acgccaucau gcaggccgcc gucugcaagg agaagaucgg cuggcgcaac      780

gacucccucc accuccuggu guucgugagc gacgccgacu cccacuucgg gauggacagc      840

aagcuggcgg gcaucgucau ccccaacgac gggcugugcc accuggacag caagaacgag      900

uacuccauga gcaccgugcu cgaguacccg accaucggcc agcugaucga caagcuggug      960

cagaacaacg uccuccugau cuucgccgug acgcaggagc agguccaccu guacgagaac     1020

uacgccaagc ucauccccgg ggccaccgug ggccugcugc agaaggacuc cggcaacauc     1080

cuccagcuga ucaucagcgc cuacgaggag cugcgguccg agguggagcu cgaggugcug     1140

ggggacaccg agggccugaa ccucagcuuc accgcgaucu gcaacaacgg gacgcuguuc     1200

cagcaccaga agaagugcuc ccacaugaag gucggcgaca ccgccagcuu cuccgugacc     1260

gucaacaucc cccacugcga gcgccggagc cgccacauca ucaucaagcc cguggggcug     1320

ggcgacgccc uggagcuccu gguguccccg gagugcaacu gcgacugcca gaaggagguc     1380

gaggugaaca gcuccaagug ccaccacggc aacgggagcu uccagugcgg cgugugcgcc     1440

ugccaccccg ggcacauggg cccccggugc gagugcgggg aggacaugcu guccaccgac     1500

agcugcaagg aggcccccga ccacccgucc ugcagcggcc gcggcgacug cuacugcggg     1560

cagugcaucu gccaccucuc ccccuacggc aacaucuacg ggcccuacug ccagugcgac     1620

aacuucagcu gcguccggca caagggccug cugugcggcg ggaacggcga cugcgacugc     1680

ggggagugcg ugugccgcag cggcuggacg ggggaguacu gcaacugcac caccuccacc     1740

gacagcugcg uguccgagga cggcguccuc ugcagcggcc gcggggacug cgugugcggc     1800

aagugcgugu gcacgaaccc cggggcgucc ggcccgaccu gcgagcggug cccgaccugc     1860

ggggaccccu gcaacagcaa gcgguccugc aucgagugcc accugagcgc cgccggccag     1920

gcccgcgagg agugcgucga caagugcaag cuggccggcg cgaccaucuc cgaggaggag     1980

gacuucagca aggacggguc cgugagcugc ucccuccagg gcgagaacga gugccugauc     2040

acguuccuga ucaccaccga caacgagggg aagaccauca uccacagcau caacgagaag     2100

gacugcccca agccgcccaa cauccccaug aucaugcucg gcgugucccu ggccauccug     2160

cucaucgggg ucgugcugcu gugcaucugg aagcuccugg ugagcuucca cgaccggaag     2220

gaggucgcca aguucgaggc cgagcgcucc aaggcgaagu ggcagacggg caccaacccc     2280

cuguaccgcg gcagcaccag caccuucaag aacgugacgu acaagcaccg ggagaagcag     2340

aagguggacc ucuccaccga cugcuga                                         2367


<210>  2032
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ITB6__Homo_sapiens__AAA36122

<400>  2032
augggcaucg agcuccucug ccucuucuuc cucuuccucg gccgcaacga ccacguccag       60

ggcggcugcg cccucggcgg cgccgagacc ugcgaggacu gccuccucau cggcccccag      120

ugcgccuggu gcgcccagga gaacuucacc caccccuccg gcgucggcga gcgcugcgac      180

acccccgcca accuccucgc caagggcugc cagcucaacu ucaucgagaa ccccgucucc      240

caggucgaga uccucaagaa caagccccuc uccgucggcc gccagaagaa cuccuccgac      300

aucguccaga ucgcccccca gucccucauc cucaagcucc gccccggcgg cgcccagacc      360

cuccaggucc acguccgcca gaccgaggac uaccccgucg accucuacua ccucauggac      420

cucuccgccu ccauggacga cgaccucaac accaucaagg agcucggcuc ccgccucucc      480

aaggagaugu ccaagcucac cuccaacuuc cgccucggcu ucggcuccuu cgucgagaag      540

cccgucuccc ccuucgucaa gaccaccccc gaggagaucg ccaaccccug cuccuccauc      600

cccuacuucu gccuccccac cuucggcuuc aagcacaucc ucccccucac caacgacgcc      660

gagcgcuuca acgagaucgu caagaaccag aagaucuccg ccaacaucga cacccccgag      720

ggcggcuucg acgccaucau gcaggccgcc gucugcaagg agaagaucgg cuggcgcaac      780

gacucccucc accuccucgu cuucgucucc gacgccgacu cccacuucgg cauggacucc      840

aagcucgccg gcaucgucau ccccaacgac ggccucugcc accucgacuc caagaacgag      900

uacuccaugu ccaccguccu cgaguacccc accaucggcc agcucaucga caagcucguc      960

cagaacaacg uccuccucau cuucgccguc acccaggagc agguccaccu cuacgagaac     1020

uacgccaagc ucauccccgg cgccaccguc ggccuccucc agaaggacuc cggcaacauc     1080

cuccagcuca ucaucuccgc cuacgaggag cuccgcuccg aggucgagcu cgagguccuc     1140

ggcgacaccg agggccucaa ccucuccuuc accgccaucu gcaacaacgg cacccucuuc     1200

cagcaccaga agaagugcuc ccacaugaag gucggcgaca ccgccuccuu cuccgucacc     1260

gucaacaucc cccacugcga gcgccgcucc cgccacauca ucaucaagcc cgucggccuc     1320

ggcgacgccc ucgagcuccu cgucuccccc gagugcaacu gcgacugcca gaaggagguc     1380

gaggucaacu ccuccaagug ccaccacggc aacggcuccu uccagugcgg cgucugcgcc     1440

ugccaccccg gccacauggg cccccgcugc gagugcggcg aggacaugcu cuccaccgac     1500

uccugcaagg aggcccccga ccaccccucc ugcuccggcc gcggcgacug cuacugcggc     1560

cagugcaucu gccaccucuc ccccuacggc aacaucuacg gccccuacug ccagugcgac     1620

aacuucuccu gcguccgcca caagggccuc cucugcggcg gcaacggcga cugcgacugc     1680

ggcgagugcg ucugccgcuc cggcuggacc ggcgaguacu gcaacugcac caccuccacc     1740

gacuccugcg ucuccgagga cggcguccuc ugcuccggcc gcggcgacug cgucugcggc     1800

aagugcgucu gcaccaaccc cggcgccucc ggccccaccu gcgagcgcug ccccaccugc     1860

ggcgaccccu gcaacuccaa gcgcuccugc aucgagugcc accucuccgc cgccggccag     1920

gcccgcgagg agugcgucga caagugcaag cucgccggcg ccaccaucuc cgaggaggag     1980

gacuucucca aggacggcuc cgucuccugc ucccuccagg gcgagaacga gugccucauc     2040

accuuccuca ucaccaccga caacgagggc aagaccauca uccacuccau caacgagaag     2100

gacugcccca agccccccaa cauccccaug aucaugcucg gcgucucccu cgccauccuc     2160

cucaucggcg ucguccuccu cugcaucugg aagcuccucg ucuccuucca cgaccgcaag     2220

gaggucgcca aguucgaggc cgagcgcucc aaggccaagu ggcagaccgg caccaacccc     2280

cucuaccgcg gcuccaccuc caccuucaag aacgucaccu acaagcaccg cgagaagcag     2340

aaggucgacc ucuccaccga cugcuga                                         2367


<210>  2033
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ITB6__Homo_sapiens__AAA36122

<400>  2033
augggcaucg agcugcucug ccuuuucuuu cuguucuugg ggagaaacga ccacgugcag       60

ggagguugug ccuuaggcgg ggcugaaacc ugcgaggauu gucugcuaau uggaccccaa      120

ugcgcauggu gugcccagga aaauuuuaca cauccuagcg gcgucgguga gaggugcgac      180

acuccagcga accuccuggc uaaggggugu cagcuuaauu ucauagaaaa cccgguuucc      240

cagguggaga uccugaaaaa uaagcccuug ucuguaggac ggcagaaaaa cucaagugau      300

auugugcaaa ucgccccuca gagccucauu cugaagcugc gcccaggcgg cgcacagacg      360

cuccaagucc acgugcgaca gaccgaggac uaccccguug auuuauauua ccugauggac      420

cuuuccgccu cuauggauga cgauuugaau acaaucaaag aacugggguc gcgucuauca      480

aaggagauga gcaagcucac uuccaacuuu agacugggau ucgguuccuu uguggaaaaa      540

ccugucucuc cauucgugaa gaccacaccc gaggagauag cuaauccuug cagcuccauc      600

ccauauuuuu gucuuccgac cuucggcuuu aaacauauuc ugcccuugac uaacgacgca      660

gaaagguuca augagaucgu aaagaaccag aaaauuucag ccaauaucga uacaccugaa      720

gggggauuug acgcuauaau gcaggccgcg guuugcaagg agaagauugg cuggcggaac      780

gauagucucc accuguuagu guucgucagc gacgcagacu cucauuucgg uauggauucc      840

aaacuggccg ggaucgugau uccaaaugac ggacucuguc accuugauuc aaagaacgaa      900

uacagcauga guaccgugcu ggaguauccc acgaucggcc aauugaucga caagcuaguc      960

cagaacaaug uucugcucau uuuugcugug acucaggagc aaguacaccu guacgaaaac     1020

uaugccaaac uuauaccugg cgcaaccgug gggcuguugc agaaagauuc uggaaauauc     1080

cuccagcuga uuaucuccgc uuacgaggaa uuacgcagcg aggucgaacu ggaggugcua     1140

ggugacacag agggccucaa ccugucguuc acugccauau gcaauaacgg gacccuuuuu     1200

cagcaucaaa agaaaugcuc ucacaugaag guuggagaua cagcguccuu cucagugacc     1260

gucaauauuc cacauuguga aagaaggagu cggcacauca ucauuaagcc cgugggcuug     1320

ggugacgccc uggagcuccu gguaagcccg gaaugcaacu gugauugcca gaaagagguu     1380

gaagugaaua guucuaagug ucaccauggg aacggcagcu uucagugcgg agucugugca     1440

ugccacccug gccauauggg gccccgcugu gagugcggag aggacaugcu uucaacggau     1500

aguuguaaag aagcuccaga ccacccuucc ugcagcgguc gaggcgacug cuacuguggg     1560

cagugcaucu gucaucuguc ucccuaugga aauauuuacg gcccauauug ccaaugugau     1620

aacuucucau gcgugagaca caaggguuug cucugugggg gcaauggaga cugcgauugu     1680

ggcgagugcg ucuguaggag uggguggacu ggagaauacu gcaacugcac aaccagcacu     1740

gacuccugug ugucugagga ugguguucug ugcucgggcc guggggacug ugugugcgga     1800

aaauguguau gcacaaaucc cggcgccagc gguccuaccu gugagcggug cccaacgugu     1860

ggggauccgu gcaacuccaa gcgcucaugu auagaaugcc acuuaagugc ugccggccag     1920

gcaagagagg aaugcgucga caaguguaaa cuggccggag cuaccaucuc ugaggaagag     1980

gauuuuagca aggacggcuc cgugucaugc agccuacagg gggagaacga augucucauu     2040

acauuccuga ucacuaccga uaaugaggga aaaacaauca uucauucuau aaacgaaaag     2100

gacugcccca aaccuccaaa uauccccaug auuaugcuug gcguuuccuu ggcgauccug     2160

cucauuggug ugguccuguu auguaucugg aagcugcuug ugaguuuuca cgauaggaag     2220

gagguagcaa aauucgaagc cgagcggagc aaggcuaaau ggcagacugg gaccaacccu     2280

uuguaucgag gaucuacauc caccuuuaag aaugugacuu acaaacaucg cgagaagcaa     2340

aagguugacc ucucaacgga cugcuga                                         2367


<210>  2034
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ITB6__Homo_sapiens__AAA36122

<400>  2034
augggcaucg agcugcugug ccuguucuuc cuguuccugg gcagaaacga ccacgugcag       60

ggcggcugcg cccugggcgg cgccgagacc ugcgaggacu gccugcugau cggcccccag      120

ugcgccuggu gcgcccagga gaacuucacc caccccagcg gcgugggcga gagaugcgac      180

acccccgcca accugcuggc caagggcugc cagcugaacu ucaucgagaa ccccgugagc      240

cagguggaga uccugaagaa caagccccug agcgugggca gacagaagaa cagcagcgac      300

aucgugcaga ucgcccccca gagccugauc cugaagcuga gacccggcgg cgcccagacc      360

cugcaggugc acgugagaca gaccgaggac uaccccgugg accuguacua ccugauggac      420

cugagcgcca gcauggacga cgaccugaac accaucaagg agcugggcag cagacugagc      480

aaggagauga gcaagcugac cagcaacuuc agacugggcu ucggcagcuu cguggagaag      540

cccgugagcc ccuucgugaa gaccaccccc gaggagaucg ccaaccccug cagcagcauc      600

cccuacuucu gccugcccac cuucggcuuc aagcacaucc ugccccugac caacgacgcc      660

gagagauuca acgagaucgu gaagaaccag aagaucagcg ccaacaucga cacccccgag      720

ggcggcuucg acgccaucau gcaggccgcc gugugcaagg agaagaucgg cuggagaaac      780

gacagccugc accugcuggu guucgugagc gacgccgaca gccacuucgg cauggacagc      840

aagcuggccg gcaucgugau ccccaacgac ggccugugcc accuggacag caagaacgag      900

uacagcauga gcaccgugcu ggaguacccc accaucggcc agcugaucga caagcuggug      960

cagaacaacg ugcugcugau cuucgccgug acccaggagc aggugcaccu guacgagaac     1020

uacgccaagc ugauccccgg cgccaccgug ggccugcugc agaaggacag cggcaacauc     1080

cugcagcuga ucaucagcgc cuacgaggag cugagaagcg agguggagcu ggaggugcug     1140

ggcgacaccg agggccugaa ccugagcuuc accgccaucu gcaacaacgg cacccuguuc     1200

cagcaccaga agaagugcag ccacaugaag gugggcgaca ccgccagcuu cagcgugacc     1260

gugaacaucc cccacugcga gagaagaagc agacacauca ucaucaagcc cgugggccug     1320

ggcgacgccc uggagcugcu ggugagcccc gagugcaacu gcgacugcca gaaggaggug     1380

gaggugaaca gcagcaagug ccaccacggc aacggcagcu uccagugcgg cgugugcgcc     1440

ugccaccccg gccacauggg ccccagaugc gagugcggcg aggacaugcu gagcaccgac     1500

agcugcaagg aggcccccga ccaccccagc ugcagcggca gaggcgacug cuacugcggc     1560

cagugcaucu gccaccugag ccccuacggc aacaucuacg gccccuacug ccagugcgac     1620

aacuucagcu gcgugagaca caagggccug cugugcggcg gcaacggcga cugcgacugc     1680

ggcgagugcg ugugcagaag cggcuggacc ggcgaguacu gcaacugcac caccagcacc     1740

gacagcugcg ugagcgagga cggcgugcug ugcagcggca gaggcgacug cgugugcggc     1800

aagugcgugu gcaccaaccc cggcgccagc ggccccaccu gcgagagaug ccccaccugc     1860

ggcgaccccu gcaacagcaa gagaagcugc aucgagugcc accugagcgc cgccggccag     1920

gccagagagg agugcgugga caagugcaag cuggccggcg ccaccaucag cgaggaggag     1980

gacuucagca aggacggcag cgugagcugc agccugcagg gcgagaacga gugccugauc     2040

accuuccuga ucaccaccga caacgagggc aagaccauca uccacagcau caacgagaag     2100

gacugcccca agccccccaa cauccccaug aucaugcugg gcgugagccu ggccauccug     2160

cugaucggcg uggugcugcu gugcaucugg aagcugcugg ugagcuucca cgacagaaag     2220

gagguggcca aguucgaggc cgagagaagc aaggccaagu ggcagaccgg caccaacccc     2280

cuguacagag gcagcaccag caccuucaag aacgugaccu acaagcacag agagaagcag     2340

aagguggacc ugagcaccga cugcuga                                         2367


<210>  2035
<211>  2367
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ITB6__Homo_sapiens__AAA36122

<400>  2035
augggcaucg agcugcucug ccuguucuuu cuuuuccugg ggagaaacga ccacgugcag       60

ggaggcugug cccucggggg agcugaaacc ugcgaggauu gucugcuuau uggcccccaa      120

ugcgccuggu gugcgcagga aaauuuuaca cauccuagcg gggucggaga gcggugcgac      180

acgccggcua accugcucgc caagggcugu cagcugaauu ucaucgaaaa ccccguuucc      240

cagguggaga uucugaaaaa uaagccucuc ucugugggcc gccaaaagaa cagcuccgau      300

aucguccaga uugcucccca gucucugauc cuuaagcuga gaccuggggg agcccagacc      360

cuccaagugc acguucggca gacagaggac uaccccgugg aucuguauua ccuuauggac      420

cugagcgccu ccauggauga cgaucucaau accaucaaag aacugggcuc ucgccugagc      480

aaggagaugu ccaagcucac aagcaacuuu agacuggggu ucggaucuuu ugucgaaaaa      540

ccuguguccc cguucguuaa gaccacaccc gaggagauug cuaauccuug cagcucuauc      600

cccuauuuuu gucuuccuac cuucggcuuu aaacauauuc ugccccucac gaacgacgcc      660

gaacgguuca augagaucgu gaagaaccag aaaauuuccg cgaauaucga uaccccggaa      720

gggggauuug acgccauuau gcaggcugcc gucugcaagg agaagaucgg cuggcgcaac      780

gauagccugc accuucuggu guucgugucu gacgcugacu cccauuucgg cauggauagc      840

aaacucgccg ggaucgucau uccuaaugac ggacuguguc accuggauuc caagaacgaa      900

uacucuauga gcacaguucu cgaguauccc accaucggcc aacugauuga caaacuugug      960

cagaacaaug ugcugcucau cuuugcgguc acacaggagc aagugcaccu guacgaaaac     1020

uaugccaaac uuauuccugg ggcuaccguu ggacugcucc agaaagauuc cggcaauauc     1080

cugcagcuga ucauuagcgc cuacgaggaa cucagaucug agguggaacu ggagguccuu     1140

ggggacacgg agggacugaa ccucuccuuc acagcuaucu gcaauaacgg cacccuguuu     1200

cagcaucaaa agaaaugcag ccacaugaag gugggcgaua cagccucuuu cagcguuacc     1260

gugaauauuc cccauuguga acggcgcucc agacacauca uuaucaagcc cgucgggcug     1320

ggagacgccc uugagcuccu ggugucuccu gaaugcaacu gugauugcca gaaagagguc     1380

gaagugaaua gcuccaagug ucaccauggc aacgggagcu uucagugcgg aguuugugcu     1440

ugccacccgg gccauauggg gccccggugu gagugcggcg aggacaugcu gucuaccgau     1500

uccuguaaag aagcgccuga ccaccccagc ugcucuggac gcggcgacug cuacuguggg     1560

cagugcaucu gucaucucuc cccuuaugga aauauuuacg gccccuauug ccaaugugau     1620

aacuucagcu gcgugagaca caaggggcug cuuuguggag gcaaugggga cugcgauugu     1680

ggcgagugcg ucugucgguc cggauggaca ggcgaauacu gcaacugcac gaccucuaca     1740

gacagcugug uguccgagga ugggguucug ugcucuggac gcggcgacug ugugugcggg     1800

aaaugugucu gcaccaaucc gggagccagc ggcccuacau gugagagaug ccccaccugu     1860

ggggauccuu gcaacuccaa gcggagcugu aucgaaugcc accucucugc ugccggccag     1920

gccagagagg aaugcgugga caaguguaaa cuggcuggag ccacgauuuc cgaggaagag     1980

gauuuuagca aggacggcuc uguguccugc agccugcagg gggagaacga augucuuauc     2040

acauuccuca uuaccaccga uaaugaggga aaaacaauca uucauucuau caacgaaaag     2100

gacugcccca aaccucccaa uaucccgaug auuaugcugg gcguuagccu ggcgauccuc     2160

cugauugggg ucgugcuucu guguaucugg aagcuccugg uguccuuuca cgaucgcaag     2220

gaggucgcua aauucgaagc cgagcggagc aaggccaaau ggcagaccgg aacaaacccu     2280

cuguauagag gcucuacguc caccuuuaag aaugugacau acaaacaucg cgagaagcaa     2340

aagguugacc uuagcaccga cugcuga                                         2367


<210>  2036
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__A0A024R4J4

<400>  2036

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Pro Glu Pro Cys Ala Leu Pro Glu Lys Pro 
225                 230                 235                 240 


Ala Val Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Ala Ala Asn Pro 
            260     


<210>  2037
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__EAW71937

<400>  2037
augugggacc ugguucucuc caucgccuug ucuguggggu gcacuggugc cgugccccuc       60

auccagucuc ggauuguggg aggcugggag ugugagaagc auucccaacc cuggcaggug      120

gcuguguaca gucauggaug ggcacacugu gggggugucc uggugcaccc ccagugggug      180

cucacagcug cccauugccu aaagaagaau agccaggucu ggcugggucg gcacaaccug      240

uuugagccug aagacacagg ccagaggguc ccugucagcc acagcuuccc acacccgcuc      300

uacaauauga gccuucugaa gcaucaaagc cuuagaccag augaagacuc cagccaugac      360

cucaugcugc uccgccuguc agagccugcc aagaucacag auguugugaa gguccugggc      420

cugcccaccc aggagccagc acuggggacc accugcuacg ccucaggcug gggcagcauc      480

gaaccagagg aguucuugcg ccccaggagu cuucagugug ugagccucca ucuccugucc      540

aaugacaugu gugcuagagc uuacucugag aaggugacag aguucauguu gugugcuggg      600

cucuggacag gugguaaaga cacuuguggg ggugauucug gggguccacu ugucuguaau      660

ggugugcuuc aagguaucac aucauggggc ccugagccau gugcccugcc ugaaaagccu      720

gcuguguaca ccaagguggu gcauuaccgg aaguggauca aggacaccau cgcagccaac      780

cccuga                                                                 786


<210>  2038
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__EAW71937

<400>  2038
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc cgugccccug       60

auccagagcc gcaucguggg cgggugggag ugcgagaagc acucccagcc guggcagguc      120

gcgguguaca gccacggcug ggcccacugc gggggcgugc ucguccaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac ucccaggugu ggcucggccg gcacaaccug      240

uucgagcccg aggacacggg gcagcgcguc cccgugagcc acuccuuccc gcacccccug      300

uacaacauga gccuccugaa gcaccagucc cugcggcccg acgaggacag cucccacgac      360

cucaugcugc ugcgccucag cgagcccgcc aagaucaccg acguggucaa ggugcugggc      420

cugccgaccc aggagcccgc gcucgggacc acgugcuacg ccuccggcug ggggagcauc      480

gagcccgagg aguuccugcg gccccgcucc cugcagugcg ugagccucca ccuccugucc      540

aacgacaugu gcgcccgggc cuacagcgag aaggucaccg aguucaugcu gugcgcgggc      600

cuguggaccg gcgggaagga cacgugcggc ggggacuccg gcggcccgcu ggugugcaac      660

ggggugcucc agggcaucac cagcuggggg cccgagcccu gcgcccugcc cgagaagccg      720

gccgucuaca ccaagguggu gcacuaccgc aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2039
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__EAW71937

<400>  2039
augugggacc ucguccucuc caucgcccuc uccgucggcu gcaccggcgc cgucccccuc       60

auccaguccc gcaucgucgg cggcugggag ugcgagaagc acucccagcc cuggcagguc      120

gccgucuacu cccacggcug ggcccacugc ggcggcgucc ucguccaccc ccaguggguc      180

cucaccgccg cccacugccu caagaagaac ucccaggucu ggcucggccg ccacaaccuc      240

uucgagcccg aggacaccgg ccagcgcguc cccgucuccc acuccuuccc ccacccccuc      300

uacaacaugu cccuccucaa gcaccagucc cuccgccccg acgaggacuc cucccacgac      360

cucaugcucc uccgccucuc cgagcccgcc aagaucaccg acgucgucaa gguccucggc      420

cuccccaccc aggagcccgc ccucggcacc accugcuacg ccuccggcug gggcuccauc      480

gagcccgagg aguuccuccg cccccgcucc cuccagugcg ucucccucca ccuccucucc      540

aacgacaugu gcgcccgcgc cuacuccgag aaggucaccg aguucaugcu cugcgccggc      600

cucuggaccg gcggcaagga caccugcggc ggcgacuccg gcggcccccu cgucugcaac      660

ggcguccucc agggcaucac cuccuggggc cccgagcccu gcgcccuccc cgagaagccc      720

gccgucuaca ccaaggucgu ccacuaccgc aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2040
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__EAW71937

<400>  2040
augugggacc uggugcucag caucgcccuu uccgucggcu gcaccggggc uguuccccug       60

auucagucua gaauaguggg agguugggag ugugaaaagc acucacaacc uuggcaggua      120

gcaguguaca gucauggcug ggcccacugc gggggagucu uggugcaucc acaguggguu      180

uuaacagcgg cucacugucu gaaaaagaac agccaggugu ggcuaggcag gcauaaucuc      240

uucgagccgg aagauacugg ucaacggguc cccguguccc acucuuuucc ucacccacug      300

uauaacaugu cgcuucugaa acaucaguca uugcgccccg acgaggauag cagucacgac      360

cucaugcugc ugcgacucuc cgaaccugcc aagaucacgg auguaguuaa aguguuaggg      420

cugccaaccc aggagcccgc acuuggaaca acuugcuacg ccucuggcug gggcagcauu      480

gagccugaag aguucuugcg uccaagaucc cugcagugug ucucacuaca ucuccugagu      540

aaugacaugu gcgcuagggc auauagcgaa aaggugaccg aguuuaugcu uugugccggg      600

cuguggacag gagguaagga uaccugcggc ggggacucug gaggcccguu gguguguaac      660

gguguccucc aagggaucac uuccugggga cccgagccuu gcgcucugcc agaaaaaccc      720

gccguuuaca caaagguggu acacuaucgg aaauggauua aggauaccau cgcggcaaau      780

ccuuga                                                                 786


<210>  2041
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__EAW71937

<400>  2041
augugggacc uggugcugag caucgcccug agcgugggcu gcaccggcgc cgugccccug       60

auccagagca gaaucguggg cggcugggag ugcgagaagc acagccagcc cuggcaggug      120

gccguguaca gccacggcug ggcccacugc ggcggcgugc uggugcaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac agccaggugu ggcugggcag acacaaccug      240

uucgagcccg aggacaccgg ccagagagug cccgugagcc acagcuuccc ccacccccug      300

uacaacauga gccugcugaa gcaccagagc cugagacccg acgaggacag cagccacgac      360

cugaugcugc ugagacugag cgagcccgcc aagaucaccg acguggugaa ggugcugggc      420

cugcccaccc aggagcccgc ccugggcacc accugcuacg ccagcggcug gggcagcauc      480

gagcccgagg aguuccugag acccagaagc cugcagugcg ugagccugca ccugcugagc      540

aacgacaugu gcgccagagc cuacagcgag aaggugaccg aguucaugcu gugcgccggc      600

cuguggaccg gcggcaagga caccugcggc ggcgacagcg gcggcccccu ggugugcaac      660

ggcgugcugc agggcaucac cagcuggggc cccgagcccu gcgcccugcc cgagaagccc      720

gccguguaca ccaagguggu gcacuacaga aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2042
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__EAW71937

<400>  2042
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc uguuccccuu       60

auucagucua gaaucguggg aggcugggag ugugaaaagc acagccaacc uuggcaagug      120

gccgucuacu cccaugggug ggcgcacugc ggaggcgugc ugguucaucc gcagugggug      180

cucacagcug cccacugucu gaaaaagaac ucucaggucu ggcuugggcg gcauaaucug      240

uucgagcccg aagauacggg acagcgcgug ccuguuagcc acuccuuucc ccacccucuc      300

uauaacaugu cucugcugaa acaucagagc cucagacccg acgaggauuc cagccacgac      360

cugaugcuuc ugcggcucuc ugaaccugcc aagauuaccg auguggucaa agugcugggc      420

cuuccgacac aggagcccgc ucugggcacc acaugcuacg ccuccgggug gggaagcauc      480

gagccugaag aguuccuccg ccccagaucu cugcagugug ugucccugca ucuccugagc      540

aaugacaugu gcgcucgggc cuauucugaa aaggucaccg aguuuaugcu uugugcgggc      600

cuguggacag ggggaaagga uaccugcggc ggggacuccg gaggcccucu cguuuguaac      660

ggcgugcugc aagggauuac gagcugggga cccgagccgu gcgcccuucc ugaaaaaccc      720

gcuguguaca ccaaggucgu gcacuaucgc aaauggauca aggauacaau cgccgcuaau      780

ccuuga                                                                 786


<210>  2043
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__A0A024R4N3

<400>  2043

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Val Ser His Pro Tyr Ser Gln His Leu Glu Gly Lys Gly 
    210                 215                 220             


<210>  2044
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__EAW71938

<400>  2044
augugggacc ugguucucuc caucgccuug ucuguggggu gcacuggugc cgugccccuc       60

auccagucuc ggauuguggg aggcugggag ugugagaagc auucccaacc cuggcaggug      120

gcuguguaca gucauggaug ggcacacugu gggggugucc uggugcaccc ccagugggug      180

cucacagcug cccauugccu aaagaagaau agccaggucu ggcugggucg gcacaaccug      240

uuugagccug aagacacagg ccagaggguc ccugucagcc acagcuuccc acacccgcuc      300

uacaauauga gccuucugaa gcaucaaagc cuuagaccag augaagacuc cagccaugac      360

cucaugcugc uccgccuguc agagccugcc aagaucacag auguugugaa gguccugggc      420

cugcccaccc aggagccagc acuggggacc accugcuacg ccucaggcug gggcagcauc      480

gaaccagagg aguucuugcg ccccaggagu cuucagugug ugagccucca ucuccugucc      540

aaugacaugu gugcuagagc uuacucugag aaggugacag aguucauguu gugugcuggg      600

cucuggacag gugguaaaga cacuuguggg gugagucauc ccuacuccca acaucuggag      660

gggaaagggu ga                                                          672


<210>  2045
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__EAW71938

<400>  2045
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc cgugccccug       60

auccagagcc gcaucguggg cgggugggag ugcgagaagc acucccagcc guggcagguc      120

gcgguguaca gccacggcug ggcccacugc gggggcgugc ucguccaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac ucccaggugu ggcucggccg gcacaaccug      240

uucgagcccg aggacaccgg gcagcgcguc cccgugagcc acuccuuccc gcacccccug      300

uacaacauga gccuccugaa gcaccagucc cugcggcccg acgaggacag cucccacgac      360

cucaugcugc ugcgccucag cgagcccgcc aagaucaccg acguggucaa ggugcugggc      420

cugccgaccc aggagcccgc gcucgggacc acgugcuacg ccuccggcug ggggagcauc      480

gagcccgagg aguuccugcg gccccgcucc cugcagugcg ugagccucca ccuccugucc      540

aacgacaugu gcgcccgggc cuacagcgag aaggucaccg aguucaugcu gugcgcgggc      600

cuguggaccg gcgggaagga cacgugcggc gugucccacc cguacagcca gcaccuggag      660

gggaagggcu ga                                                          672


<210>  2046
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__EAW71938

<400>  2046
augugggacc ucguccucuc caucgcccuc uccgucggcu gcaccggcgc cgucccccuc       60

auccaguccc gcaucgucgg cggcugggag ugcgagaagc acucccagcc cuggcagguc      120

gccgucuacu cccacggcug ggcccacugc ggcggcgucc ucguccaccc ccaguggguc      180

cucaccgccg cccacugccu caagaagaac ucccaggucu ggcucggccg ccacaaccuc      240

uucgagcccg aggacaccgg ccagcgcguc cccgucuccc acuccuuccc ccacccccuc      300

uacaacaugu cccuccucaa gcaccagucc cuccgccccg acgaggacuc cucccacgac      360

cucaugcucc uccgccucuc cgagcccgcc aagaucaccg acgucgucaa gguccucggc      420

cuccccaccc aggagcccgc ccucggcacc accugcuacg ccuccggcug gggcuccauc      480

gagcccgagg aguuccuccg cccccgcucc cuccagugcg ucucccucca ccuccucucc      540

aacgacaugu gcgcccgcgc cuacuccgag aaggucaccg aguucaugcu cugcgccggc      600

cucuggaccg gcggcaagga caccugcggc gucucccacc ccuacuccca gcaccucgag      660

ggcaagggcu ga                                                          672


<210>  2047
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__EAW71938

<400>  2047
augugggacc uggugcucag caucgcccuu uccgucggcu gcaccggggc uguuccccug       60

auucagucua gaauaguggg agguugggag ugugaaaagc acucacaacc uuggcaggua      120

gcaguguaca gucauggcug ggcccacugc gggggagucu uggugcaucc acaguggguu      180

uuaacagcgg cucacugucu gaaaaagaac agccaggugu ggcuaggcag gcauaaucuc      240

uucgagccgg aagauacugg ucaacggguc cccguguccc acucuuuucc ucacccacug      300

uauaacaugu cgcuucugaa acaucaguca uugcgccccg acgaggauag cagucacgac      360

cucaugcugc ugcgacucuc cgaaccugcc aagaucacgg auguaguuaa aguguuaggg      420

cugccaaccc aggagcccgc acuuggaaca acuugcuacg ccucuggcug gggcagcauu      480

gagccugaag aguucuugcg uccaagaucc cugcagugug ucucacuaca ucuccugagu      540

aaugacaugu gcgcuagggc auauagcgaa aaggugaccg aguuuaugcu uugugccggg      600

cuguggacag gagguaagga uaccugcggc gugucucacc cguacuccca acacuuggag      660

gggaaaggau ga                                                          672


<210>  2048
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__EAW71938

<400>  2048
augugggacc uggugcugag caucgcccug agcgugggcu gcaccggcgc cgugccccug       60

auccagagca gaaucguggg cggcugggag ugcgagaagc acagccagcc cuggcaggug      120

gccguguaca gccacggcug ggcccacugc ggcggcgugc uggugcaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac agccaggugu ggcugggcag acacaaccug      240

uucgagcccg aggacaccgg ccagagagug cccgugagcc acagcuuccc ccacccccug      300

uacaacauga gccugcugaa gcaccagagc cugagacccg acgaggacag cagccacgac      360

cugaugcugc ugagacugag cgagcccgcc aagaucaccg acguggugaa ggugcugggc      420

cugcccaccc aggagcccgc ccugggcacc accugcuacg ccagcggcug gggcagcauc      480

gagcccgagg aguuccugag acccagaagc cugcagugcg ugagccugca ccugcugagc      540

aacgacaugu gcgccagagc cuacagcgag aaggugaccg aguucaugcu gugcgccggc      600

cuguggaccg gcggcaagga caccugcggc gugagccacc ccuacagcca gcaccuggag      660

ggcaagggcu ga                                                          672


<210>  2049
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__EAW71938

<400>  2049
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc uguuccccuu       60

auucagucua gaaucguggg aggcugggag ugugaaaagc acagccaacc uuggcaagug      120

gccgucuacu cccaugggug ggcgcacugc ggaggcgugc ugguucaucc gcagugggug      180

cucacagcug cccacugucu gaaaaagaac ucucaggucu ggcuugggcg gcauaaucug      240

uucgagcccg aagauacggg acagcgcgug ccuguuagcc acuccuuucc ccacccucuc      300

uauaacaugu cucugcugaa acaucagagc cucagacccg acgaggauuc cagccacgac      360

cugaugcuuc ugcggcucuc ugaaccugcc aagauuaccg auguggucaa agugcugggc      420

cuuccgacac aggagcccgc ucugggcacc acaugcuacg ccuccgggug gggaagcauc      480

gagccugaag aguuccuccg ccccagaucu cugcagugug ugucccugca ucuccugagc      540

aaugacaugu gcgcucgggc cuauucugaa aaggucaccg aguuuaugcu uugugcgggc      600

cuguggacag ggggaaagga uaccugcggc guuucccacc cuuacagcca acaccucgag      660

gggaaaggau ga                                                          672


<210>  2050
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__B0AZU9

<400>  2050

Met Ser Leu Leu Lys His Gln Ser Leu Arg Pro Asp Glu Asp Ser Ser 
1               5                   10                  15      


His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Lys Ile Thr Asp 
            20                  25                  30          


Val Val Lys Val Leu Gly Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr 
        35                  40                  45              


Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu 
    50                  55                  60          


<210>  2051
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__BAF98781

<400>  2051
augagccuuc ugaagcauca aagccuuaga ccagaugaag acuccagcca ugaccucaug       60

cugcuucgcc ugucagagcc ugccaagauc acagauguug ugaagguccu gggccugccc      120

acccaggagc cagcacuggg gaccaccugc uacgccucag gcuggggcag caucgaacca      180

gaggaguga                                                              189


<210>  2052
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__BAF98781

<400>  2052
augagccugc ucaagcacca gucccugcgc cccgacgagg acagcuccca cgaccugaug       60

cuccugcggc ugagcgagcc ggccaagauc accgacgugg ucaaggugcu cggccugccc      120

acccaggagc ccgcccuggg gacgaccugc uacgcguccg gcugggggag caucgagccc      180

gaggaguga                                                              189


<210>  2053
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__BAF98781

<400>  2053
augucccucc ucaagcacca gucccuccgc cccgacgagg acuccuccca cgaccucaug       60

cuccuccgcc ucuccgagcc cgccaagauc accgacgucg ucaagguccu cggccucccc      120

acccaggagc ccgcccucgg caccaccugc uacgccuccg gcuggggcuc caucgagccc      180

gaggaguga                                                              189


<210>  2054
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__BAF98781

<400>  2054
augagccugc ucaagcacca gucccuuaga cccgacgagg auucuucaca ugaccugaug       60

uuguuaaggc ugagugaacc ugccaaaauc accgaugugg ucaagguucu aggccuccca      120

acacaagagc cggcucuggg gacuacgugc uacgcaagcg gaugggguuc cauugaaccc      180

gaggaauga                                                              189


<210>  2055
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__BAF98781

<400>  2055
augagccugc ugaagcacca gagccugaga cccgacgagg acagcagcca cgaccugaug       60

cugcugagac ugagcgagcc cgccaagauc accgacgugg ugaaggugcu gggccugccc      120

acccaggagc ccgcccuggg caccaccugc uacgccagcg gcuggggcag caucgagccc      180

gaggaguga                                                              189


<210>  2056
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__BAF98781

<400>  2056
augagccugc ucaagcacca gucccugaga cccgacgagg auucuagcca ugaccuuaug       60

cugcuccggc uguccgaacc ugccaaaauc accgaugugg ucaagguucu uggccugccg      120

acacaagagc ccgcucucgg gacgaccugc uacgccucug gauggggcag cauugaaccu      180

gaggaauga                                                              189


<210>  2057
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__B4DU77

<400>  2057

Met Gly Thr Leu Trp Gly Cys Pro Gly Ala Pro Pro Val Gly Ala His 
1               5                   10                  15      


Ser Cys Pro Leu Pro Lys Glu Val Ser Arg Thr Leu Gly Ser Gly Glu 
            20                  25                  30          


Gly Met Ala Val Ser His Arg Asn Asn Ser Gly Met Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Leu Arg Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu Phe 
    50                  55                  60                  


Glu Pro Glu Asp Thr Gly Arg Arg Val Pro Val Ser His Ser Phe Pro 
65                  70                  75                  80  


His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg Pro 
                85                  90                  95      


Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro 
            100                 105                 110         


Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln Glu 
        115                 120                 125             


Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu 
    130                 135                 140                 


Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu His 
145                 150                 155                 160 


Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val Thr 
                165                 170                 175     


Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr Cys 
            180                 185                 190         


Gly Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly 
        195                 200                 205             


Ile Thr Ser Trp Gly Pro Glu Pro Cys Ala Leu Pro Glu Lys Pro Ala 
    210                 215                 220                 


Val Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr Ile 
225                 230                 235                 240 


Ala Ala Asn Pro 
                


<210>  2058
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__BAG62239

<400>  2058
augggcacac ugugggggug uccuggugca cccccagugg gugcucacag cugcccauug       60

ccuaaagaag uaaguaggac ccugggaucu ggggagggaa uggcuguguc ccacaggaau      120

aacagcggga ugcuuccccc agggucacuu cucaggaaua gccaggucug gcugggucgg      180

cacaaccugu uugagccuga agacacaggc cggagggucc cugucagcca cagcuuccca      240

cacccgcucu acaauaugag ccuucugaag caucaaagcc uuagaccaga ugaagacucc      300

agccaugacc ucaugcugcu ccgccuguca gagccugcca agaucacaga uguugugaag      360

guccugggcc ugcccaccca ggagccagca cuggggacca ccugcuacgc cucaggcugg      420

ggcagcaucg aaccagagga guucuugcgc cccaggaguc uucagugugu gagccuccau      480

cuccugucca augacaugug ugcuagagcu uacucugaga aggugacaga guucauguug      540

ugugcugggc ucuggacagg ugguaaagac acuugugggg gugauucugg ggguccacuu      600

gucuguaaug gugugcuuca agguaucaca ucauggggcc cugagccaug ugcccugccu      660

gaaaagccug cuguguacac caagguggug cauuaccgga aguggaucaa ggacaccauc      720

gcagccaacc ccuga                                                       735


<210>  2059
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__BAG62239

<400>  2059
augggcaccc ugugggggug ccccggcgcc ccgcccgugg gggcccacag cugcccccuc       60

cccaaggagg ucucccgcac ccugggcagc ggggagggca uggcgguguc ccaccggaac      120

aacagcggca ugcugccgcc cgggucccuc cugcgcaaca gccaggugug gcugggccgg      180

cacaaccucu ucgagcccga ggacacgggg cgccgggucc ccguguccca cagcuucccg      240

cacccccugu acaacauguc ccugcucaag caccagagcc ugcgccccga cgaggacucc      300

agccacgacc ugaugcuccu gcggcugucc gagcccgcca agaucaccga cguggucaag      360

gugcucggcc ugccgaccca ggagcccgcc cuggggacca cgugcuacgc cagcggcugg      420

ggcuccaucg agcccgagga guuccuccgc ccccggagcc ugcagugcgu gucccugcac      480

cuccugagca acgacaugug cgcccgcgcg uacuccgaga aggucaccga guucaugcug      540

ugcgccgggc ucuggaccgg cgggaaggac acgugcggcg gcgacagcgg gggcccgcug      600

gugugcaacg gggugcugca gggcaucacc agcugggggc ccgagcccug cgcccucccc      660

gagaagccgg ccgucuacac caagguggug cacuaccgga aguggaucaa ggacaccauc      720

gcggccaacc ccuga                                                       735


<210>  2060
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__BAG62239

<400>  2060
augggcaccc ucuggggcug ccccggcgcc ccccccgucg gcgcccacuc cugcccccuc       60

cccaaggagg ucucccgcac ccucggcucc ggcgagggca uggccgucuc ccaccgcaac      120

aacuccggca ugcucccccc cggcucccuc cuccgcaacu cccaggucug gcucggccgc      180

cacaaccucu ucgagcccga ggacaccggc cgccgcgucc ccgucuccca cuccuucccc      240

cacccccucu acaacauguc ccuccucaag caccaguccc uccgccccga cgaggacucc      300

ucccacgacc ucaugcuccu ccgccucucc gagcccgcca agaucaccga cgucgucaag      360

guccucggcc uccccaccca ggagcccgcc cucggcacca ccugcuacgc cuccggcugg      420

ggcuccaucg agcccgagga guuccuccgc ccccgcuccc uccagugcgu cucccuccac      480

cuccucucca acgacaugug cgcccgcgcc uacuccgaga aggucaccga guucaugcuc      540

ugcgccggcc ucuggaccgg cggcaaggac accugcggcg gcgacuccgg cggcccccuc      600

gucugcaacg gcguccucca gggcaucacc uccuggggcc ccgagcccug cgcccucccc      660

gagaagcccg ccgucuacac caaggucguc cacuaccgca aguggaucaa ggacaccauc      720

gccgccaacc ccuga                                                       735


<210>  2061
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__BAG62239

<400>  2061
augggcaccc ugugggggug ccccggagcc ccuccagugg gugcucacag cuguccgcuc       60

cccaaggagg ucuccagaac acuuggcucu ggggaaggaa uggcaguuuc acauaggaac      120

aauaguggca ugcugccucc agguagcuug uuacggaacu cccaggugug gcuggggcgc      180

cacaaucuau ucgagcccga agacacugga cgacguguac cugugucuca uucguuucca      240

cacccccucu acaacauguc acugcuuaaa caucaaagcc ugagaccuga ugaggacagu      300

ucccacgauu ugaugcuccu gaggcugucu gaaccagcca agaucacgga cgucgugaaa      360

guucucggcu uaccgaccca ggagcccgcg cugggcacaa cuugcuaugc uagcgggugg      420

ggauccauug agccugaaga guuccuucgg ccacgcucau ugcagugugu gagucugcac      480

cuacucagca augauaugug cgccagagca uacucugaaa aggucaccga guuuaugcug      540

ugugccgguc uuuggacagg cgggaaagau accugcggag gcgacuccgg ugggccccug      600

guguguaacg gaguauugca gggcauaacu ucauggggcc cugagccaug cgcucucccc      660

gaaaagccgg caguuuauac aaaggugguc cauuacagga aauggaucaa ggacaccauu      720

gccgcuaauc cuuga                                                       735


<210>  2062
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__BAG62239

<400>  2062
augggcaccc uguggggcug ccccggcgcc ccccccgugg gcgcccacag cugcccccug       60

cccaaggagg ugagcagaac ccugggcagc ggcgagggca uggccgugag ccacagaaac      120

aacagcggca ugcugccccc cggcagccug cugagaaaca gccaggugug gcugggcaga      180

cacaaccugu ucgagcccga ggacaccggc agaagagugc ccgugagcca cagcuucccc      240

cacccccugu acaacaugag ccugcugaag caccagagcc ugagacccga cgaggacagc      300

agccacgacc ugaugcugcu gagacugagc gagcccgcca agaucaccga cguggugaag      360

gugcugggcc ugcccaccca ggagcccgcc cugggcacca ccugcuacgc cagcggcugg      420

ggcagcaucg agcccgagga guuccugaga cccagaagcc ugcagugcgu gagccugcac      480

cugcugagca acgacaugug cgccagagcc uacagcgaga aggugaccga guucaugcug      540

ugcgccggcc uguggaccgg cggcaaggac accugcggcg gcgacagcgg cggcccccug      600

gugugcaacg gcgugcugca gggcaucacc agcuggggcc ccgagcccug cgcccugccc      660

gagaagcccg ccguguacac caagguggug cacuacagaa aguggaucaa ggacaccauc      720

gccgccaacc ccuga                                                       735


<210>  2063
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__BAG62239

<400>  2063
augggcaccc ugugggggug ccccggagcc ccuccggugg gcgcucacag cuguccccuc       60

ccuaaggagg ucuccagaac acuggggucu ggagaaggca uggccguuag ccaucggaac      120

aauuccggga ugcuuccccc uggaucucug cuccgcaaca gccaggugug gcugggcaga      180

cacaaucuuu ucgagcccga agacacgggc cggcgcgugc cugucuccca uucuuuuccg      240

cacccccugu acaacaugag ccuccugaaa caucaauccc ugagaccuga ugaggacagc      300

ucucacgauc ucaugcugcu ucggcugucc gaacccgcga agaucaccga cgugguuaaa      360

gugcucgggc ugccuacaca ggagcccgcu cuuggaacca caugcuaugc cagcggcugg      420

gggucuauug agccggaaga guuccugcgc ccuagauccc uccagugugu cagccugcau      480

cugcucucua augauaugug cgcccgggcu uacuccgaaa aggugaccga guuuaugcug      540

ugugccggac uuuggacagg cgggaaagau accugcggag gcgacagcgg cgggccccug      600

guuuguaacg gagugcucca gggcaucacg uccugggggc cugagcccug cgcucugccc      660

gaaaagccug ccgucuauac caagguggug cacuaccgca aauggauuaa ggacacaauc      720

gcggccaauc cguga                                                       735


<210>  2064
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__P20151

<400>  2064

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Pro Glu Pro Cys Ala Leu Pro Glu Lys Pro 
225                 230                 235                 240 


Ala Val Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Ala Ala Asn Pro 
            260     


<210>  2065
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__AAA74454

<400>  2065
augugggacc ugguucucuc caucgccuug ucuguggggu gcacuggugc cgugccccuc       60

auccagucuc ggauuguggg aggcugggag ugugagaagc auucccaacc cuggcaggug      120

gcuguguaca gucauggaug ggcacacugu gggggugucc uggugcaccc ccagugggug      180

cucacagcug cccauugccu aaagaagaau agccaggucu ggcugggucg gcacaaccug      240

uuugagccug aagacacagg ccagaggguc ccugucagcc acagcuuccc acacccgcuc      300

uacaauauga gccuucugaa gcaucaaagc cuuagaccag augaagacuc cagccaugac      360

cucaugcugc uccgccuguc agagccugcc aagaucacag auguugugaa gguccugggc      420

cugcccaccc aggagccagc acuggggacc accugcuacg ccucaggcug gggcagcauc      480

gaaccagagg aguucuugcg ccccaggagu cuucagugug ugagccucca ucuccugucc      540

aaugacaugu gugcuagagc uuacucugag aaggugacag aguucauguu gugugcuggg      600

cucuggacag gugguaaaga cacuuguggg ggugauucug gggguccacu ugucuguaau      660

ggggugcuuc aagguaucac aucauggggc ccugagccau gugcccugcc ugaaaagccu      720

gcuguguaca ccaagguggu gcauuaccgg aaguggauca aggacaccau cgcagccaac      780

cccuga                                                                 786


<210>  2066
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__AAA74454

<400>  2066
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc cgugccccug       60

auccagagcc gcaucguggg cgggugggag ugcgagaagc acucccagcc guggcagguc      120

gcgguguaca gccacggcug ggcccacugc gggggcgugc ucguccaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac ucccaggugu ggcucggccg gcacaaccug      240

uucgagcccg aggacacggg gcagcgcguc cccgugagcc acuccuuccc gcacccccug      300

uacaacauga gccuccugaa gcaccagucc cugcggcccg acgaggacag cucccacgac      360

cucaugcugc ugcgccucag cgagcccgcc aagaucaccg acguggucaa ggugcugggc      420

cugccgaccc aggagcccgc gcucgggacc acgugcuacg ccuccggcug ggggagcauc      480

gagcccgagg aguuccugcg gccccgcucc cugcagugcg ugagccucca ccuccugucc      540

aacgacaugu gcgcccgggc cuacagcgag aaggucaccg aguucaugcu gugcgcgggc      600

cuguggaccg gcgggaagga cacgugcggc ggggacuccg gcggcccgcu ggugugcaac      660

ggggugcucc agggcaucac cagcuggggg cccgagcccu gcgcccugcc cgagaagccg      720

gccgucuaca ccaagguggu gcacuaccgc aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2067
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__AAA74454

<400>  2067
augugggacc ucguccucuc caucgcccuc uccgucggcu gcaccggcgc cgucccccuc       60

auccaguccc gcaucgucgg cggcugggag ugcgagaagc acucccagcc cuggcagguc      120

gccgucuacu cccacggcug ggcccacugc ggcggcgucc ucguccaccc ccaguggguc      180

cucaccgccg cccacugccu caagaagaac ucccaggucu ggcucggccg ccacaaccuc      240

uucgagcccg aggacaccgg ccagcgcguc cccgucuccc acuccuuccc ccacccccuc      300

uacaacaugu cccuccucaa gcaccagucc cuccgccccg acgaggacuc cucccacgac      360

cucaugcucc uccgccucuc cgagcccgcc aagaucaccg acgucgucaa gguccucggc      420

cuccccaccc aggagcccgc ccucggcacc accugcuacg ccuccggcug gggcuccauc      480

gagcccgagg aguuccuccg cccccgcucc cuccagugcg ucucccucca ccuccucucc      540

aacgacaugu gcgcccgcgc cuacuccgag aaggucaccg aguucaugcu cugcgccggc      600

cucuggaccg gcggcaagga caccugcggc ggcgacuccg gcggcccccu cgucugcaac      660

ggcguccucc agggcaucac cuccuggggc cccgagcccu gcgcccuccc cgagaagccc      720

gccgucuaca ccaaggucgu ccacuaccgc aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2068
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__AAA74454

<400>  2068
augugggacc uggugcucag caucgcccuu uccgucggcu gcaccggggc uguuccccug       60

auucagucua gaauaguggg agguugggag ugugaaaagc acucacaacc uuggcaggua      120

gcaguguaca gucauggcug ggcccacugc gggggagucu uggugcaucc acaguggguu      180

uuaacagcgg cucacugucu gaaaaagaac agccaggugu ggcuaggcag gcauaaucuc      240

uucgagccgg aagauacugg ucaacggguc cccguguccc acucuuuucc ucacccacug      300

uauaacaugu cgcuucugaa acaucaguca uugcgccccg acgaggauag cagucacgac      360

cucaugcugc ugcgacucuc cgaaccugcc aagaucacgg auguaguuaa aguguuaggg      420

cugccaaccc aggagcccgc acuuggaaca acuugcuacg ccucuggcug gggcagcauu      480

gagccugaag aguucuugcg uccaagaucc cugcagugug ucucacuaca ucuccugagu      540

aaugacaugu gcgcuagggc auauagcgaa aaggugaccg aguuuaugcu uugugccggg      600

cuguggacag gagguaagga uaccugcggc ggggacucug gaggcccguu gguguguaac      660

gguguccucc aagggaucac uuccugggga cccgagccuu gcgcucugcc agaaaaaccc      720

gccguuuaca caaagguggu acacuaucgg aaauggauua aggauaccau cgcggcaaau      780

ccuuga                                                                 786


<210>  2069
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__AAA74454

<400>  2069
augugggacc uggugcugag caucgcccug agcgugggcu gcaccggcgc cgugccccug       60

auccagagca gaaucguggg cggcugggag ugcgagaagc acagccagcc cuggcaggug      120

gccguguaca gccacggcug ggcccacugc ggcggcgugc uggugcaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac agccaggugu ggcugggcag acacaaccug      240

uucgagcccg aggacaccgg ccagagagug cccgugagcc acagcuuccc ccacccccug      300

uacaacauga gccugcugaa gcaccagagc cugagacccg acgaggacag cagccacgac      360

cugaugcugc ugagacugag cgagcccgcc aagaucaccg acguggugaa ggugcugggc      420

cugcccaccc aggagcccgc ccugggcacc accugcuacg ccagcggcug gggcagcauc      480

gagcccgagg aguuccugag acccagaagc cugcagugcg ugagccugca ccugcugagc      540

aacgacaugu gcgccagagc cuacagcgag aaggugaccg aguucaugcu gugcgccggc      600

cuguggaccg gcggcaagga caccugcggc ggcgacagcg gcggcccccu ggugugcaac      660

ggcgugcugc agggcaucac cagcuggggc cccgagcccu gcgcccugcc cgagaagccc      720

gccguguaca ccaagguggu gcacuacaga aaguggauca aggacaccau cgccgccaac      780

cccuga                                                                 786


<210>  2070
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__AAA74454

<400>  2070
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc uguuccccuu       60

auucagucua gaaucguggg aggcugggag ugugaaaagc acagccaacc uuggcaagug      120

gccgucuacu cccaugggug ggcgcacugc ggaggcgugc ugguucaucc gcagugggug      180

cucacagcug cccacugucu gaaaaagaac ucucaggucu ggcuugggcg gcauaaucug      240

uucgagcccg aagauacggg acagcgcgug ccuguuagcc acuccuuucc ccacccucuc      300

uauaacaugu cucugcugaa acaucagagc cucagacccg acgaggauuc cagccacgac      360

cugaugcuuc ugcggcucuc ugaaccugcc aagauuaccg auguggucaa agugcugggc      420

cuuccgacac aggagcccgc ucugggcacc acaugcuacg ccuccgggug gggaagcauc      480

gagccugaag aguuccuccg ccccagaucu cugcagugug ugucccugca ucuccugagc      540

aaugacaugu gcgcucgggc cuauucugaa aaggucaccg aguuuaugcu uugugcgggc      600

cuguggacag ggggaaagga uaccugcggc ggggacuccg gaggcccucu cguuuguaac      660

ggcgugcugc aagggauuac gagcugggga cccgagccgu gcgcccuucc ugaaaaaccc      720

gcuguguaca ccaaggucgu gcacuaucgc aaauggauca aggauacaau cgccgcuaau      780

ccuuga                                                                 786


<210>  2071
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__Q6T774

<400>  2071

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ile Ala Arg Ser Gly Trp Val Gly Thr Thr Cys Leu Ser Leu Lys Thr 
            20                  25                  30          


Gln Ala Arg Gly Ser Leu Ser Ala Thr Ala Ser His Thr Arg Ser Thr 
        35                  40                  45              


Ile 
    


<210>  2072
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__AAR10469

<400>  2072
augugggacc ugguucucuc caucgccuug ucuguggggu gcacuggaau agccaggucu       60

ggcugggucg gcacaaccug uuugagccug aagacacagg ccagaggguc ccugucagcc      120

acagcuuccc acacccgcuc uacaauauga                                       150


<210>  2073
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__AAR10469

<400>  2073
augugggacc uggugcucag caucgcccug uccgucggcu gcaccgggau cgcccgcagc       60

ggcugggugg ggaccacgug ccugucccuc aagacccagg cgcggggcag ccuguccgcc      120

accgccagcc acacccgcuc cacgaucuga                                       150


<210>  2074
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__AAR10469

<400>  2074
augugggacc ucguccucuc caucgcccuc uccgucggcu gcaccggcau cgcccgcucc       60

ggcugggucg gcaccaccug ccucucccuc aagacccagg cccgcggcuc ccucuccgcc      120

accgccuccc acacccgcuc caccaucuga                                       150


<210>  2075
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__AAR10469

<400>  2075
augugggacc uggugcucag caucgcccuu uccgucggcu gcaccgggau ugcuagaucu       60

ggauggguug guacaacuug ucugucauug aagacgcagg caaggggcag uuuaagcgcc      120

accgcguccc acacacgguc uacuauauga                                       150


<210>  2076
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__AAR10469

<400>  2076
augugggacc uggugcugag caucgcccug agcgugggcu gcaccggcau cgccagaagc       60

ggcugggugg gcaccaccug ccugagccug aagacccagg ccagaggcag ccugagcgcc      120

accgccagcc acaccagaag caccaucuga                                       150


<210>  2077
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__AAR10469

<400>  2077
augugggacc uggugcucag caucgcccug uccgucggcu gcaccgggau ugcuagaucu       60

ggauggguug gcacaacgug ucuuagccug aagacccagg cccggggguc ccucucugcg      120

acagcuagcc acacccgcuc cacaaucuga                                       150


<210>  2078
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__Q6T775

<400>  2078

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Cys Thr Pro Gly Pro Asp Gly Val Ala Gly Ser Pro 
                165                 170                 175     


Asp Ala Trp Val 
            180 


<210>  2079
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-2__Homo_sapiens__AAR10468

<400>  2079
augugggacc ugguucucuc caucgccuug ucuguggggu gcacuggugc cgugccccuc       60

auccagucuc ggauuguggg aggcugggag ugugagaagc auucccaacc cuggcaggug      120

gcuguguaca gucauggaug ggcacacugu gggggugucc uggugcaccc ccagugggug      180

cucacagcug cccauugccu aaagaagaau agccaggucu ggcugggucg gcacaaccug      240

uuugagccug aagacacagg ccagaggguc ccugucagcc acagcuuccc acacccgcuc      300

uacaauauga gccuucugaa gcaucaaagc cuuagaccag augaagacuc cagccaugac      360

cucaugcugc uccgccuguc agagccugcc aagaucacag auguugugaa gguccugggc      420

cugcccaccc aggagccagc acuggggacc accugcuacg ccucaggcug gggcagcauc      480

gaaccagagg aguguacgcc ugggccagau gguguagcug ggagcccaga ugccuggguc      540

uga                                                                    543


<210>  2080
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-2__Homo_sapiens__AAR10468

<400>  2080
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc cgugccccug       60

auccagagcc gcaucguggg cgggugggag ugcgagaagc acucccagcc guggcagguc      120

gcgguguaca gccacggcug ggcccacugc gggggcgugc ucguccaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac ucccaggugu ggcucggccg gcacaaccug      240

uucgagcccg aggacacggg gcagcgcguc cccgugagcc acuccuuccc gcacccccug      300

uacaacauga gccuccugaa gcaccagucc cugcggcccg acgaggacag cucccacgac      360

cucaugcugc ugcgccucag cgagcccgcc aagaucaccg acguggucaa ggugcugggc      420

cugccgaccc aggagcccgc gcucgggacc acgugcuacg ccuccggcug ggggagcauc      480

gagcccgagg agugcacccc cggcccggac ggcguggccg ggucccccga cgccuggguc      540

uga                                                                    543


<210>  2081
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-2__Homo_sapiens__AAR10468

<400>  2081
augugggacc ucguccucuc caucgcccuc uccgucggcu gcaccggcgc cgucccccuc       60

auccaguccc gcaucgucgg cggcugggag ugcgagaagc acucccagcc cuggcagguc      120

gccgucuacu cccacggcug ggcccacugc ggcggcgucc ucguccaccc ccaguggguc      180

cucaccgccg cccacugccu caagaagaac ucccaggucu ggcucggccg ccacaaccuc      240

uucgagcccg aggacaccgg ccagcgcguc cccgucuccc acuccuuccc ccacccccuc      300

uacaacaugu cccuccucaa gcaccagucc cuccgccccg acgaggacuc cucccacgac      360

cucaugcucc uccgccucuc cgagcccgcc aagaucaccg acgucgucaa gguccucggc      420

cuccccaccc aggagcccgc ccucggcacc accugcuacg ccuccggcug gggcuccauc      480

gagcccgagg agugcacccc cggccccgac ggcgucgccg gcucccccga cgccuggguc      540

uga                                                                    543


<210>  2082
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-2__Homo_sapiens__AAR10468

<400>  2082
augugggacc uggugcucag caucgcccuu uccgucggcu gcaccggggc uguuccccug       60

auucagucua gaauaguggg agguugggag ugugaaaagc acucacaacc uuggcaggua      120

gcaguguaca gucauggcug ggcccacugc gggggagucu uggugcaucc acaguggguu      180

uuaacagcgg cucacugucu gaaaaagaac agccaggugu ggcuaggcag gcauaaucuc      240

uucgagccgg aagauacugg ucaacggguc cccguguccc acucuuuucc ucacccacug      300

uauaacaugu cgcuucugaa acaucaguca uugcgccccg acgaggauag cagucacgac      360

cucaugcugc ugcgacucuc cgaaccugcc aagaucacgg auguaguuaa aguguuaggg      420

cugccaaccc aggagcccgc acuuggaaca acuugcuacg ccucuggcug gggcagcauu      480

gagccugaag aguguacccc agggccggac ggagucgcug guucccccga ugcaugggug      540

uga                                                                    543


<210>  2083
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-2__Homo_sapiens__AAR10468

<400>  2083
augugggacc uggugcugag caucgcccug agcgugggcu gcaccggcgc cgugccccug       60

auccagagca gaaucguggg cggcugggag ugcgagaagc acagccagcc cuggcaggug      120

gccguguaca gccacggcug ggcccacugc ggcggcgugc uggugcaccc ccagugggug      180

cugaccgccg cccacugccu gaagaagaac agccaggugu ggcugggcag acacaaccug      240

uucgagcccg aggacaccgg ccagagagug cccgugagcc acagcuuccc ccacccccug      300

uacaacauga gccugcugaa gcaccagagc cugagacccg acgaggacag cagccacgac      360

cugaugcugc ugagacugag cgagcccgcc aagaucaccg acguggugaa ggugcugggc      420

cugcccaccc aggagcccgc ccugggcacc accugcuacg ccagcggcug gggcagcauc      480

gagcccgagg agugcacccc cggccccgac ggcguggccg gcagccccga cgccugggug      540

uga                                                                    543


<210>  2084
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-2__Homo_sapiens__AAR10468

<400>  2084
augugggacc uggugcucag caucgcccug uccgucggcu gcaccggggc uguuccccuu       60

auucagucua gaaucguggg aggcugggag ugugaaaagc acagccaacc uuggcaagug      120

gccgucuacu cccaugggug ggcgcacugc ggaggcgugc ugguucaucc gcagugggug      180

cucacagcug cccacugucu gaaaaagaac ucucaggucu ggcuugggcg gcauaaucug      240

uucgagcccg aagauacggg acagcgcgug ccuguuagcc acuccuuucc ccacccucuc      300

uauaacaugu cucugcugaa acaucagagc cucagacccg acgaggauuc cagccacgac      360

cugaugcuuc ugcggcucuc ugaaccugcc aagauuaccg auguggucaa agugcugggc      420

cuuccgacac aggagcccgc ucugggcacc acaugcuacg ccuccgggug gggaagcauc      480

gagccugaag aguguacccc cggcccugac gggguggcug gaucucccga ugccuggguc      540

uga                                                                    543


<210>  2085
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__A0A0C4DFQ5

<400>  2085

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Arg 
145                 150                 155                 160 


Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser Glu Glu 
                165                 170                 175     


Val Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys 
            180                 185                 190         


Ala Gly Gly Gly Gln Asp Gln Lys Asp Ser Cys Asn Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Ile Cys Asn Gly Tyr Leu Gln Gly Leu Val Ser Phe Gly 
    210                 215                 220                 


Lys Ala Pro Cys Gly Gln Val Gly Val Pro Gly Val Tyr Thr Asn Leu 
225                 230                 235                 240 


Cys Lys Phe Thr Glu Trp Ile Glu Lys Thr Val Gln Ala Ser 
                245                 250                 


<210>  2086
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__EAW71943

<400>  2086
auggccacag caggaaaucc cuggggcugg uuccuggggu accucauccu uggugucgca       60

ggaucgcucg ucucugguag cugcagccaa aucauaaacg gcgaggacug cagcccgcac      120

ucgcagcccu ggcaggcggc acuggucaug gaaaacgaau uguucugcuc gggcguccug      180

gugcauccgc agugggugcu gucagccgca cacuguuucc agaacuccua caccaucggg      240

cugggccugc acagucuuga ggccgaccaa gagccaggga gccagauggu ggaggccagc      300

cucuccguac ggcacccaga guacaacaga cccuugcucg cuaacgaccu caugcucauc      360

aaguuggacg aauccguguc cgagucugac accauccgga gcaucagcau ugcuucgcag      420

ugcccuaccg cggggaacuc uugccucguu ucuggcuggg gucugcuggc gaacggcaga      480

augccuaccg ugcugcagug cgugaacgug ucgguggugu cugaggaggu cugcaguaag      540

cucuaugacc cgcuguacca ccccagcaug uucugcgccg gcggagggca agaccagaag      600

gacuccugca acggugacuc uggggggccc cugaucugca acggguacuu gcagggccuu      660

gugucuuucg gaaaagcccc guguggccaa guuggcgugc caggugucua caccaaccuc      720

ugcaaauuca cugaguggau agagaaaacc guccaggcca guuaa                      765


<210>  2087
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-4__Homo_sapiens__EAW71943

<400>  2087
auggccaccg ccggcaaccc cugggggugg uuccugggcu accucauccu ggggguggcg       60

ggcagccugg ucuccgggag cugcucccag aucaucaacg gcgaggacug cagcccgcac      120

ucccagcccu ggcaggccgc ccucgugaug gagaacgagc uguucugcag cggcgugcug      180

guccaccccc agugggugcu cuccgccgcc cacugcuucc agaacagcua caccaucggg      240

cugggccugc acucccucga ggcggaccag gagcccggga gccagauggu ggaggccucc      300

cugagcgucc gccacccgga guacaaccgg ccccugcucg ccaacgaccu gaugcugauc      360

aagcucgacg aguccgugag cgaguccgac acgauccgca gcaucuccau cgccagccag      420

ugccccaccg cgggcaacuc cugccuggug agcggguggg gccugcucgc caacggccgg      480

augcccaccg uccugcagug cgugaacgug agcgucgugu ccgaggaggu gugcagcaag      540

cuguacgacc cgcucuacca ccccuccaug uucugcgccg ggggcgggca ggaccagaag      600

gacagcugca acggcgacuc cggcgggccc cugaucugca acggcuaccu gcaggggcuc      660

gucagcuucg gcaaggcccc cugcggccag gugggggugc cgggcgucua caccaaccug      720

ugcaaguuca cggaguggau cgagaagacc gugcaggccu ccuga                      765


<210>  2088
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-4__Homo_sapiens__EAW71943

<400>  2088
auggccaccg ccggcaaccc cuggggcugg uuccucggcu accucauccu cggcgucgcc       60

ggcucccucg ucuccggcuc cugcucccag aucaucaacg gcgaggacug cuccccccac      120

ucccagcccu ggcaggccgc ccucgucaug gagaacgagc ucuucugcuc cggcguccuc      180

guccaccccc aguggguccu cuccgccgcc cacugcuucc agaacuccua caccaucggc      240

cucggccucc acucccucga ggccgaccag gagcccggcu cccagauggu cgaggccucc      300

cucuccgucc gccaccccga guacaaccgc ccccuccucg ccaacgaccu caugcucauc      360

aagcucgacg aguccgucuc cgaguccgac accauccgcu ccaucuccau cgccucccag      420

ugccccaccg ccggcaacuc cugccucguc uccggcuggg gccuccucgc caacggccgc      480

augcccaccg uccuccagug cgucaacguc uccgucgucu ccgaggaggu cugcuccaag      540

cucuacgacc cccucuacca ccccuccaug uucugcgccg gcggcggcca ggaccagaag      600

gacuccugca acggcgacuc cggcggcccc cucaucugca acggcuaccu ccagggccuc      660

gucuccuucg gcaaggcccc cugcggccag gucggcgucc ccggcgucua caccaaccuc      720

ugcaaguuca ccgaguggau cgagaagacc guccaggccu ccuga                      765


<210>  2089
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-4__Homo_sapiens__EAW71943

<400>  2089
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu ugguguggca       60

ggcagccugg ucuccggguc uugcucacag auuauaaaug gagaggacug uaguccucac      120

agccaaccau ggcaggccgc guugguuaug gaaaacgagu uauuuugcuc cggcgugcug      180

guacauccgc agugggugcu aucugcugcc cacuguuucc aaaauucgua uacaaucggu      240

cucgggcugc auucacuuga agcagaucag gagcccggaa gccagauggu cgaagccagu      300

cuguccguga gacacccuga guacaacagg ccauugcucg cuaaugaccu gaugcugauu      360

aagcucgaug agucuguuag cgaauccgac acuauccggu caauuaguau cgcaagccag      420

ugccccacgg ccggcaacuc uuguuuagug uccggcuggg ggcugcuugc uaauggacgc      480

augccuaccg ucuugcagug cgugaacgua ucaguuguga gcgaggaagu cuguaguaaa      540

cuguaugauc cacuauacca ucccucuaug uuuugcgccg guggcgggca agaccagaag      600

gauuccugua auggagacag cggcgguccu cucauaugca acggguaucu gcagggacuu      660

gugucguucg gcaaagcgcc auguggccag gugggggucc cgggaguuua cacaaaucug      720

ugcaaguuua cugaguggau cgagaaaacc gugcaagcau cuuga                      765


<210>  2090
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-4__Homo_sapiens__EAW71943

<400>  2090
auggccaccg ccggcaaccc cuggggcugg uuccugggcu accugauccu gggcguggcc       60

ggcagccugg ugagcggcag cugcagccag aucaucaacg gcgaggacug cagcccccac      120

agccagcccu ggcaggccgc ccuggugaug gagaacgagc uguucugcag cggcgugcug      180

gugcaccccc agugggugcu gagcgccgcc cacugcuucc agaacagcua caccaucggc      240

cugggccugc acagccugga ggccgaccag gagcccggca gccagauggu ggaggccagc      300

cugagcguga gacaccccga guacaacaga ccccugcugg ccaacgaccu gaugcugauc      360

aagcuggacg agagcgugag cgagagcgac accaucagaa gcaucagcau cgccagccag      420

ugccccaccg ccggcaacag cugccuggug agcggcuggg gccugcuggc caacggcaga      480

augcccaccg ugcugcagug cgugaacgug agcgugguga gcgaggaggu gugcagcaag      540

cuguacgacc cccuguacca ccccagcaug uucugcgccg gcggcggcca ggaccagaag      600

gacagcugca acggcgacag cggcggcccc cugaucugca acggcuaccu gcagggccug      660

gugagcuucg gcaaggcccc cugcggccag gugggcgugc ccggcgugua caccaaccug      720

ugcaaguuca ccgaguggau cgagaagacc gugcaggcca gcuga                      765


<210>  2091
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-4__Homo_sapiens__EAW71943

<400>  2091
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu gggcguggcc       60

gggagccuug ucuccggauc uugcagccag auuaucaaug gcgaggacug uuccccucac      120

ucucaaccgu ggcaggcggc ucugguuaug gaaaacgagc ucuuuugcag cggggugcug      180

gugcaucccc aguggguccu uuccgccgcc cacuguuucc aaaauucuua uacaauugga      240

cugggccucc auagccugga agcugaucag gagccuggcu cccagauggu ggaagccagc      300

cugucuguua gacaccccga guacaaccgg ccucuccugg cuaaugaccu uaugcugauc      360

aagcucgaug aguccgugag cgaaucugac acgauucgcu ccaucagcau cgccucucag      420

ugccccaccg cggggaacuc cugucugguc agcggauggg gccuucuggc caaugggaga      480

augccuacag ugcuccagug cguuaacgug uccgucgugu cugaggaagu guguagcaaa      540

cuguaugauc cgcuguacca ucccuccaug uuuugcgcug gaggcgggca agaccagaag      600

gauagcugua auggagacuc uggcggcccu cucauuugca acggguaucu gcagggacuu      660

gucuccuucg gcaaagcccc cugugggcag guuggagugc cuggcgugua caccaaucug      720

ugcaaguuua cagaguggau cgagaaaacc guccaagcua gcuga                      765


<210>  2092
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__Q5BQA0

<400>  2092

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Lys 
65                  70                  75  


<210>  2093
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__AAX30051

<400>  2093
auggccacag caggaaaucc cuggggcugg uuccuggggu accucauccu uggugucgca       60

ggaucgcucg ucucugguag cugcagccaa aucauaaacg gcgaggacug cagcccgcac      120

ucgcagcccu ggcaggcggc acuggucaug gaaaacgaau uguucugcuc gggcguccug      180

gugcauccgc agugggugcu gucagccgca cacuguuucc agaaguga                   228


<210>  2094
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-4__Homo_sapiens__AAX30051

<400>  2094
auggccaccg ccggcaaccc cugggggugg uuccugggcu accucauccu ggggguggcg       60

ggcagccugg ucuccgggag cugcucccag aucaucaacg gcgaggacug cagcccgcac      120

ucccagcccu ggcaggccgc ccucgugaug gagaacgagc uguucugcag cggcgugcug      180

guccaccccc agugggugcu cuccgccgcc cacugcuucc agaaguga                   228


<210>  2095
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-4__Homo_sapiens__AAX30051

<400>  2095
auggccaccg ccggcaaccc cuggggcugg uuccucggcu accucauccu cggcgucgcc       60

ggcucccucg ucuccggcuc cugcucccag aucaucaacg gcgaggacug cuccccccac      120

ucccagcccu ggcaggccgc ccucgucaug gagaacgagc ucuucugcuc cggcguccuc      180

guccaccccc aguggguccu cuccgccgcc cacugcuucc agaaguga                   228


<210>  2096
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-4__Homo_sapiens__AAX30051

<400>  2096
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu ugguguggca       60

ggcagccugg ucuccggguc uugcucacag auuauaaaug gagaggacug uaguccucac      120

agccaaccau ggcaggccgc guugguuaug gaaaacgagu uauuuugcuc cggcgugcug      180

guacauccgc agugggugcu aucugcugcc cacuguuucc agaaguga                   228


<210>  2097
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-4__Homo_sapiens__AAX30051

<400>  2097
auggccaccg ccggcaaccc cuggggcugg uuccugggcu accugauccu gggcguggcc       60

ggcagccugg ugagcggcag cugcagccag aucaucaacg gcgaggacug cagcccccac      120

agccagcccu ggcaggccgc ccuggugaug gagaacgagc uguucugcag cggcgugcug      180

gugcaccccc agugggugcu gagcgccgcc cacugcuucc agaaguga                   228


<210>  2098
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-4__Homo_sapiens__AAX30051

<400>  2098
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu gggcguggcc       60

gggagccuug ucuccggauc uugcagccag auuaucaaug gcgaggacug uuccccucac      120

ucucaaccgu ggcaggcggc ucugguuaug gaaaacgagc ucuuuugcag cggggugcug      180

gugcaucccc aguggguccu uuccgccgcc cacuguuucc agaaguga                   228


<210>  2099
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__Q96PT0

<400>  2099

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Glu 
145                 150                 155                 160 


Leu Thr Gly Val Cys Leu Pro Ser Ser Arg Arg Ser Ser Ala Gln Ser 
                165                 170                 175     


Arg Gly Leu Thr Gln Ser Ser Ala Ser Gln Ala Glu Cys Leu Pro Cys 
            180                 185                 190         


Cys Ser Ala 
        195 


<210>  2100
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__AAL14782

<400>  2100
auggccacag caggaaaucc cuggggcugg uuccuggggu accucauccu uggugucgca       60

ggaucucucg ucucugguag cugcagccaa aucauaaacg gcgaggacug cagcccgcac      120

ucgcagcccu ggcaggcggc acuggucaug gaaaacgaau uguucugcuc gggcguccug      180

gugcauccgc agugggugcu gucagccgca cacuguuucc agaacuccua caccaucggg      240

cugggccugc acagucuuga ggccgaccaa gagccaggga gccagauggu ggaggccagc      300

cucuccguac ggcacccaga guacaacaga cccuugcucg cuaacgaccu caugcucauc      360

aaguuggacg aauccguguc cgagucugac accauccgga gcaucagcau ugcuucgcag      420

ugcccuaccg cggggaacuc uugccucguu ucuggcuggg gucugcuggc gaacggugag      480

cucacgggug ugugucugcc cucuucaagg agguccucug cccagucgcg ggggcugacc      540

cagagcucug cgucccaggc agaaugccua ccgugcugca gugcguga                   588


<210>  2101
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-4__Homo_sapiens__AAL14782

<400>  2101
auggccaccg ccggcaaccc cugggggugg uuccugggcu accucauccu ggggguggcg       60

ggcagccugg ucuccgggag cugcucccag aucaucaacg gcgaggacug cagcccgcac      120

ucccagcccu ggcaggccgc ccucgugaug gagaacgagc uguucugcag cggcgugcug      180

guccaccccc agugggugcu cuccgccgcc cacugcuucc agaacagcua caccaucggg      240

cugggccugc acucccucga ggcggaccag gagcccggga gccagauggu ggaggccucc      300

cugagcgucc gccacccgga guacaaccgg ccccugcucg ccaacgaccu gaugcugauc      360

aagcucgacg aguccgugag cgaguccgac acgauccgca gcaucuccau cgccagccag      420

ugccccaccg cgggcaacuc cugccuggug agcggguggg gccugcucgc caacggcgag      480

cugaccgggg ucugccugcc cagcucccgg cgcagcuccg cccagagccg gggccucacc      540

caguccagcg ccucccaggc cgagugccug ccgugcugca gcgcguga                   588


<210>  2102
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-4__Homo_sapiens__AAL14782

<400>  2102
auggccaccg ccggcaaccc cuggggcugg uuccucggcu accucauccu cggcgucgcc       60

ggcucccucg ucuccggcuc cugcucccag aucaucaacg gcgaggacug cuccccccac      120

ucccagcccu ggcaggccgc ccucgucaug gagaacgagc ucuucugcuc cggcguccuc      180

guccaccccc aguggguccu cuccgccgcc cacugcuucc agaacuccua caccaucggc      240

cucggccucc acucccucga ggccgaccag gagcccggcu cccagauggu cgaggccucc      300

cucuccgucc gccaccccga guacaaccgc ccccuccucg ccaacgaccu caugcucauc      360

aagcucgacg aguccgucuc cgaguccgac accauccgcu ccaucuccau cgccucccag      420

ugccccaccg ccggcaacuc cugccucguc uccggcuggg gccuccucgc caacggcgag      480

cucaccggcg ucugccuccc cuccucccgc cgcuccuccg cccagucccg cggccucacc      540

caguccuccg ccucccaggc cgagugccuc cccugcugcu ccgccuga                   588


<210>  2103
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-4__Homo_sapiens__AAL14782

<400>  2103
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu ugguguggca       60

ggcagccugg ucuccggguc uugcucacag auuauaaaug gagaggacug uaguccucac      120

agccaaccau ggcaggccgc guugguuaug gaaaacgagu uauuuugcuc cggcgugcug      180

guacauccgc agugggugcu aucugcugcc cacuguuucc aaaauucgua uacaaucggu      240

cucgggcugc auucacuuga agcagaucag gagcccggaa gccagauggu cgaagccagu      300

cuguccguga gacacccuga guacaacagg ccauugcucg cuaaugaccu gaugcugauu      360

aagcucgaug agucuguuag cgaauccgac acuauccggu caauuaguau cgcaagccag      420

ugccccacgg ccggcaacuc uuguuuagug uccggcuggg ggcugcuugc uaauggagag      480

uugaccggug ucugccugcc uucaagccgc cgaaguucug cccagucccg uggccuaaca      540

caaagcucgg cgucucaggc agaaugucuc ccaugcuguu ccgccuga                   588


<210>  2104
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-4__Homo_sapiens__AAL14782

<400>  2104
auggccaccg ccggcaaccc cuggggcugg uuccugggcu accugauccu gggcguggcc       60

ggcagccugg ugagcggcag cugcagccag aucaucaacg gcgaggacug cagcccccac      120

agccagcccu ggcaggccgc ccuggugaug gagaacgagc uguucugcag cggcgugcug      180

gugcaccccc agugggugcu gagcgccgcc cacugcuucc agaacagcua caccaucggc      240

cugggccugc acagccugga ggccgaccag gagcccggca gccagauggu ggaggccagc      300

cugagcguga gacaccccga guacaacaga ccccugcugg ccaacgaccu gaugcugauc      360

aagcuggacg agagcgugag cgagagcgac accaucagaa gcaucagcau cgccagccag      420

ugccccaccg ccggcaacag cugccuggug agcggcuggg gccugcuggc caacggcgag      480

cugaccggcg ugugccugcc cagcagcaga agaagcagcg cccagagcag aggccugacc      540

cagagcagcg ccagccaggc cgagugccug cccugcugca gcgccuga                   588


<210>  2105
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-4__Homo_sapiens__AAL14782

<400>  2105
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu gggcguggcc       60

gggagccuug ucuccggauc uugcagccag auuaucaaug gcgaggacug uuccccucac      120

ucucaaccgu ggcaggcggc ucugguuaug gaaaacgagc ucuuuugcag cggggugcug      180

gugcaucccc aguggguccu uuccgccgcc cacuguuucc aaaauucuua uacaauugga      240

cugggccucc auagccugga agcugaucag gagccuggcu cccagauggu ggaagccagc      300

cugucuguua gacaccccga guacaaccgg ccucuccugg cuaaugaccu uaugcugauc      360

aagcucgaug aguccgugag cgaaucugac acgauucgcu ccaucagcau cgccucucag      420

ugccccaccg cggggaacuc cugucugguc agcggauggg gccuucuggc caauggggag      480

cucacaggag ugugccugcc uuccucuaga cggagcuccg cucagagccg cggccugacc      540

caaucuuccg ccagccaggc ugaaugucuc ccgugcuguu cugccuga                   588


<210>  2106
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__Q96PT1

<400>  2106

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly 
145                 150                 155                 


<210>  2107
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__AAL14781

<400>  2107
auggccacag caggaaaucc cuggggcugg uuccuggggu accucauccu uggugucgca       60

ggaucucucg ucucugguag cugcagccaa aucauaaacg gcgaggacug cagcccgcac      120

ucgcagcccu ggcaggcggc acuggucaug gaaaacgaau uguucugcuc gggcguccug      180

gugcauccgc agugggugcu gucagccgca cacuguuucc agaacuccua caccaucggg      240

cugggccugc acagucuuga ggccgaccaa gagccaggga gccagauggu ggaggccagc      300

cucuccguac ggcacccaga guacaacaga cccuugcucg cuaacgaccu caugcucauc      360

aaguuggacg aauccguguc cgagucugac accauccgga gcaucagcau ugcuucgcag      420

ugcccuaccg cggggaacuc uugccucguu ucuggcuggg gucugcuggc gaacggguga      480


<210>  2108
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-4__Homo_sapiens__AAL14781

<400>  2108
auggccaccg ccggcaaccc cugggggugg uuccugggcu accucauccu ggggguggcg       60

ggcagccugg ucuccgggag cugcucccag aucaucaacg gcgaggacug cagcccgcac      120

ucccagcccu ggcaggccgc ccucgugaug gagaacgagc uguucugcag cggcgugcug      180

guccaccccc agugggugcu cuccgccgcc cacugcuucc agaacagcua caccaucggg      240

cugggccugc acucccucga ggcggaccag gagcccggga gccagauggu ggaggccucc      300

cugagcgucc gccacccgga guacaaccgg ccccugcucg ccaacgaccu gaugcugauc      360

aagcucgacg aguccgugag cgaguccgac acgauccgca gcaucuccau cgccagccag      420

ugccccaccg cgggcaacuc cugccuggug agcggguggg gccugcucgc caacggcuga      480


<210>  2109
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-4__Homo_sapiens__AAL14781

<400>  2109
auggccaccg ccggcaaccc cuggggcugg uuccucggcu accucauccu cggcgucgcc       60

ggcucccucg ucuccggcuc cugcucccag aucaucaacg gcgaggacug cuccccccac      120

ucccagcccu ggcaggccgc ccucgucaug gagaacgagc ucuucugcuc cggcguccuc      180

guccaccccc aguggguccu cuccgccgcc cacugcuucc agaacuccua caccaucggc      240

cucggccucc acucccucga ggccgaccag gagcccggcu cccagauggu cgaggccucc      300

cucuccgucc gccaccccga guacaaccgc ccccuccucg ccaacgaccu caugcucauc      360

aagcucgacg aguccgucuc cgaguccgac accauccgcu ccaucuccau cgccucccag      420

ugccccaccg ccggcaacuc cugccucguc uccggcuggg gccuccucgc caacggcuga      480


<210>  2110
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-4__Homo_sapiens__AAL14781

<400>  2110
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu ugguguggca       60

ggcagccugg ucuccggguc uugcucacag auuauaaaug gagaggacug uaguccucac      120

agccaaccau ggcaggccgc guugguuaug gaaaacgagu uauuuugcuc cggcgugcug      180

guacauccgc agugggugcu aucugcugcc cacuguuucc aaaauucgua uacaaucggu      240

cucgggcugc auucacuuga agcagaucag gagcccggaa gccagauggu cgaagccagu      300

cuguccguga gacacccuga guacaacagg ccauugcucg cuaaugaccu gaugcugauu      360

aagcucgaug agucuguuag cgaauccgac acuauccggu caauuaguau cgcaagccag      420

ugccccacgg ccggcaacuc uuguuuagug uccggcuggg ggcugcuugc uaauggauga      480


<210>  2111
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-4__Homo_sapiens__AAL14781

<400>  2111
auggccaccg ccggcaaccc cuggggcugg uuccugggcu accugauccu gggcguggcc       60

ggcagccugg ugagcggcag cugcagccag aucaucaacg gcgaggacug cagcccccac      120

agccagcccu ggcaggccgc ccuggugaug gagaacgagc uguucugcag cggcgugcug      180

gugcaccccc agugggugcu gagcgccgcc cacugcuucc agaacagcua caccaucggc      240

cugggccugc acagccugga ggccgaccag gagcccggca gccagauggu ggaggccagc      300

cugagcguga gacaccccga guacaacaga ccccugcugg ccaacgaccu gaugcugauc      360

aagcuggacg agagcgugag cgagagcgac accaucagaa gcaucagcau cgccagccag      420

ugccccaccg ccggcaacag cugccuggug agcggcuggg gccugcuggc caacggcuga      480


<210>  2112
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-4__Homo_sapiens__AAL14781

<400>  2112
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu gggcguggcc       60

gggagccuug ucuccggauc uugcagccag auuaucaaug gcgaggacug uuccccucac      120

ucucaaccgu ggcaggcggc ucugguuaug gaaaacgagc ucuuuugcag cggggugcug      180

gugcaucccc aguggguccu uuccgccgcc cacuguuucc aaaauucuua uacaauugga      240

cugggccucc auagccugga agcugaucag gagccuggcu cccagauggu ggaagccagc      300

cugucuguua gacaccccga guacaaccgg ccucuccugg cuaaugaccu uaugcugauc      360

aagcucgaug aguccgugag cgaaucugac acgauucgcu ccaucagcau cgccucucag      420

ugccccaccg cggggaacuc cugucugguc agcggauggg gccuucuggc caauggguga      480


<210>  2113
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__Q9Y5K2

<400>  2113

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Arg 
145                 150                 155                 160 


Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser Glu Glu 
                165                 170                 175     


Val Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys 
            180                 185                 190         


Ala Gly Gly Gly His Asp Gln Lys Asp Ser Cys Asn Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Ile Cys Asn Gly Tyr Leu Gln Gly Leu Val Ser Phe Gly 
    210                 215                 220                 


Lys Ala Pro Cys Gly Gln Val Gly Val Pro Gly Val Tyr Thr Asn Leu 
225                 230                 235                 240 


Cys Lys Phe Thr Glu Trp Ile Glu Lys Thr Val Gln Ala Ser 
                245                 250                 


<210>  2114
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  kallikrein-4__Homo_sapiens__AAD21580

<400>  2114
auggccacag caggaaaucc cuggggcugg uuccuggggu accucauccu uggugucgca       60

ggaucgcucg ucucugguag cugcagccaa aucauaaacg gcgaggacug cagcccgcac      120

ucgcagcccu ggcaggcggc acuggucaug gaaaacgaau uguucugcuc gggcguccug      180

gugcauccgc agugggugcu gucagccgca cacuguuucc agaacuccua caccaucggg      240

cugggccugc acagucuuga ggccgaccaa gagccaggga gccagauggu ggaggccagc      300

cucuccguac ggcacccaga guacaacaga cccuugcucg cuaacgaccu caugcucauc      360

aaguuggacg aauccguguc cgagucugac accauccgga gcaucagcau ugcuucgcag      420

ugcccuaccg cggggaacuc uugccucguu ucuggcuggg gucugcuggc gaacggcaga      480

augccuaccg ugcugcagug cgugaacgug ucgguggugu cugaggaggu cugcaguaag      540

cucuaugacc cgcuguacca ccccagcaug uucugcgccg gcggagggca cgaccagaag      600

gacuccugca acggugacuc uggggggccc cugaucugca acggguacuu gcagggccuu      660

gugucuuucg gaaaagcccc guguggccaa guuggcgugc caggugucua caccaaccuc      720

ugcaaauuca cugaguggau agagaaaacc guccaggcca guuaa                      765


<210>  2115
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       kallikrein-4__Homo_sapiens__AAD21580

<400>  2115
auggccaccg ccggcaaccc cugggggugg uuccugggcu accucauccu ggggguggcg       60

ggcagccugg ucuccgggag cugcucccag aucaucaacg gcgaggacug cagcccgcac      120

ucccagcccu ggcaggccgc ccucgugaug gagaacgagc uguucugcag cggcgugcug      180

guccaccccc agugggugcu cuccgccgcc cacugcuucc agaacagcua caccaucggg      240

cugggccugc acucccucga ggcggaccag gagcccggga gccagauggu ggaggccucc      300

cugagcgucc gccacccgga guacaaccgg ccccugcucg ccaacgaccu gaugcugauc      360

aagcucgacg aguccgugag cgaguccgac acgauccgca gcaucuccau cgccagccag      420

ugccccaccg cgggcaacuc cugccuggug agcggguggg gccugcucgc caacggccgg      480

augcccaccg uccugcagug cgugaacgug agcgucgugu ccgaggaggu gugcagcaag      540

cuguacgacc cgcucuacca ccccuccaug uucugcgccg ggggcgggca cgaccagaag      600

gacagcugca acggcgacuc cggcgggccc cugaucugca acggcuaccu gcaggggcuc      660

gucagcuucg gcaaggcccc cugcggccag gugggggugc cgggcgucua caccaaccug      720

ugcaaguuca cggaguggau cgagaagacc gugcaggccu ccuga                      765


<210>  2116
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       kallikrein-4__Homo_sapiens__AAD21580

<400>  2116
auggccaccg ccggcaaccc cuggggcugg uuccucggcu accucauccu cggcgucgcc       60

ggcucccucg ucuccggcuc cugcucccag aucaucaacg gcgaggacug cuccccccac      120

ucccagcccu ggcaggccgc ccucgucaug gagaacgagc ucuucugcuc cggcguccuc      180

guccaccccc aguggguccu cuccgccgcc cacugcuucc agaacuccua caccaucggc      240

cucggccucc acucccucga ggccgaccag gagcccggcu cccagauggu cgaggccucc      300

cucuccgucc gccaccccga guacaaccgc ccccuccucg ccaacgaccu caugcucauc      360

aagcucgacg aguccgucuc cgaguccgac accauccgcu ccaucuccau cgccucccag      420

ugccccaccg ccggcaacuc cugccucguc uccggcuggg gccuccucgc caacggccgc      480

augcccaccg uccuccagug cgucaacguc uccgucgucu ccgaggaggu cugcuccaag      540

cucuacgacc cccucuacca ccccuccaug uucugcgccg gcggcggcca cgaccagaag      600

gacuccugca acggcgacuc cggcggcccc cucaucugca acggcuaccu ccagggccuc      660

gucuccuucg gcaaggcccc cugcggccag gucggcgucc ccggcgucua caccaaccuc      720

ugcaaguuca ccgaguggau cgagaagacc guccaggccu ccuga                      765


<210>  2117
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       kallikrein-4__Homo_sapiens__AAD21580

<400>  2117
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu ugguguggca       60

ggcagccugg ucuccggguc uugcucacag auuauaaaug gagaggacug uaguccucac      120

agccaaccau ggcaggccgc guugguuaug gaaaacgagu uauuuugcuc cggcgugcug      180

guacauccgc agugggugcu aucugcugcc cacuguuucc aaaauucgua uacaaucggu      240

cucgggcugc auucacuuga agcagaucag gagcccggaa gccagauggu cgaagccagu      300

cuguccguga gacacccuga guacaacagg ccauugcucg cuaaugaccu gaugcugauu      360

aagcucgaug agucuguuag cgaauccgac acuauccggu caauuaguau cgcaagccag      420

ugccccacgg ccggcaacuc uuguuuagug uccggcuggg ggcugcuugc uaauggacgc      480

augccuaccg ucuugcagug cgugaacgua ucaguuguga gcgaggaagu cuguaguaaa      540

cuguaugauc cacuauacca ucccucuaug uuuugcgccg guggcgggca cgaccaaaag      600

gauuccugua auggagacag cggcgguccu cucauaugca acggguaucu gcagggacuu      660

gugucguucg gcaaagcgcc auguggccag gugggggucc cgggaguuua cacaaaucug      720

ugcaaguuua cugaguggau cgagaaaacc gugcaggcau cuuga                      765


<210>  2118
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       kallikrein-4__Homo_sapiens__AAD21580

<400>  2118
auggccaccg ccggcaaccc cuggggcugg uuccugggcu accugauccu gggcguggcc       60

ggcagccugg ugagcggcag cugcagccag aucaucaacg gcgaggacug cagcccccac      120

agccagcccu ggcaggccgc ccuggugaug gagaacgagc uguucugcag cggcgugcug      180

gugcaccccc agugggugcu gagcgccgcc cacugcuucc agaacagcua caccaucggc      240

cugggccugc acagccugga ggccgaccag gagcccggca gccagauggu ggaggccagc      300

cugagcguga gacaccccga guacaacaga ccccugcugg ccaacgaccu gaugcugauc      360

aagcuggacg agagcgugag cgagagcgac accaucagaa gcaucagcau cgccagccag      420

ugccccaccg ccggcaacag cugccuggug agcggcuggg gccugcuggc caacggcaga      480

augcccaccg ugcugcagug cgugaacgug agcgugguga gcgaggaggu gugcagcaag      540

cuguacgacc cccuguacca ccccagcaug uucugcgccg gcggcggcca cgaccagaag      600

gacagcugca acggcgacag cggcggcccc cugaucugca acggcuaccu gcagggccug      660

gugagcuucg gcaaggcccc cugcggccag gugggcgugc ccggcgugua caccaaccug      720

ugcaaguuca ccgaguggau cgagaagacc gugcaggcca gcuga                      765


<210>  2119
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       kallikrein-4__Homo_sapiens__AAD21580

<400>  2119
auggccaccg cuggcaaccc cugggggugg uuccugggau accucauccu gggcguggcc       60

gggagccuug ucuccggauc uugcagccag auuaucaaug gcgaggacug uuccccucac      120

ucucaaccgu ggcaggcggc ucugguuaug gaaaacgagc ucuuuugcag cggggugcug      180

gugcaucccc aguggguccu uuccgccgcc cacuguuucc aaaauucuua uacaauugga      240

cugggccucc auagccugga agcugaucag gagccuggcu cccagauggu ggaagccagc      300

cugucuguua gacaccccga guacaaccgg ccucuccugg cuaaugaccu uaugcugauc      360

aagcucgaug aguccgugag cgaaucugac acgauucgcu ccaucagcau cgccucucag      420

ugccccaccg cggggaacuc cugucugguc agcggauggg gccuucuggc caaugggaga      480

augccuacag ugcuccagug cguuaacgug uccgucgugu cugaggaagu guguagcaaa      540

cuguaugauc cgcuguacca ucccuccaug uuuugcgcug gaggcgggca cgaccaaaag      600

gauagcugua auggagacuc uggcggcccu cucauuugca acggguaucu gcagggacuu      660

gucuccuucg gcaaagcccc cugugggcag guuggagugc cuggcgugua caccaaucug      720

ugcaaguuua cagaguggau cgagaaaacc guccaggcua gcuga                      765


<210>  2120
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KI20A__Homo_sapiens__O95235

<400>  2120

Met Ser Gln Gly Ile Leu Ser Pro Pro Ala Gly Leu Leu Ser Asp Asp 
1               5                   10                  15      


Asp Val Val Val Ser Pro Met Phe Glu Ser Thr Ala Ala Asp Leu Gly 
            20                  25                  30          


Ser Val Val Arg Lys Asn Leu Leu Ser Asp Cys Ser Val Val Ser Thr 
        35                  40                  45              


Ser Leu Glu Asp Lys Gln Gln Val Pro Ser Glu Asp Ser Met Glu Lys 
    50                  55                  60                  


Val Lys Val Tyr Leu Arg Val Arg Pro Leu Leu Pro Ser Glu Leu Glu 
65                  70                  75                  80  


Arg Gln Glu Asp Gln Gly Cys Val Arg Ile Glu Asn Val Glu Thr Leu 
                85                  90                  95      


Val Leu Gln Ala Pro Lys Asp Ser Phe Ala Leu Lys Ser Asn Glu Arg 
            100                 105                 110         


Gly Ile Gly Gln Ala Thr His Arg Phe Thr Phe Ser Gln Ile Phe Gly 
        115                 120                 125             


Pro Glu Val Gly Gln Ala Ser Phe Phe Asn Leu Thr Val Lys Glu Met 
    130                 135                 140                 


Val Lys Asp Val Leu Lys Gly Gln Asn Trp Leu Ile Tyr Thr Tyr Gly 
145                 150                 155                 160 


Val Thr Asn Ser Gly Lys Thr His Thr Ile Gln Gly Thr Ile Lys Asp 
                165                 170                 175     


Gly Gly Ile Leu Pro Arg Ser Leu Ala Leu Ile Phe Asn Ser Leu Gln 
            180                 185                 190         


Gly Gln Leu His Pro Thr Pro Asp Leu Lys Pro Leu Leu Ser Asn Glu 
        195                 200                 205             


Val Ile Trp Leu Asp Ser Lys Gln Ile Arg Gln Glu Glu Met Lys Lys 
    210                 215                 220                 


Leu Ser Leu Leu Asn Gly Gly Leu Gln Glu Glu Glu Leu Ser Thr Ser 
225                 230                 235                 240 


Leu Lys Arg Ser Val Tyr Ile Glu Ser Arg Ile Gly Thr Ser Thr Ser 
                245                 250                 255     


Phe Asp Ser Gly Ile Ala Gly Leu Ser Ser Ile Ser Gln Cys Thr Ser 
            260                 265                 270         


Ser Ser Gln Leu Asp Glu Thr Ser His Arg Trp Ala Gln Pro Asp Thr 
        275                 280                 285             


Ala Pro Leu Pro Val Pro Ala Asn Ile Arg Phe Ser Ile Trp Ile Ser 
    290                 295                 300                 


Phe Phe Glu Ile Tyr Asn Glu Leu Leu Tyr Asp Leu Leu Glu Pro Pro 
305                 310                 315                 320 


Ser Gln Gln Arg Lys Arg Gln Thr Leu Arg Leu Cys Glu Asp Gln Asn 
                325                 330                 335     


Gly Asn Pro Tyr Val Lys Asp Leu Asn Trp Ile His Val Gln Asp Ala 
            340                 345                 350         


Glu Glu Ala Trp Lys Leu Leu Lys Val Gly Arg Lys Asn Gln Ser Phe 
        355                 360                 365             


Ala Ser Thr His Leu Asn Gln Asn Ser Ser Arg Ser His Ser Ile Phe 
    370                 375                 380                 


Ser Ile Arg Ile Leu His Leu Gln Gly Glu Gly Asp Ile Val Pro Lys 
385                 390                 395                 400 


Ile Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser Glu Arg Cys Lys 
                405                 410                 415     


Asp Gln Lys Ser Gly Glu Arg Leu Lys Glu Ala Gly Asn Ile Asn Thr 
            420                 425                 430         


Ser Leu His Thr Leu Gly Arg Cys Ile Ala Ala Leu Arg Gln Asn Gln 
        435                 440                 445             


Gln Asn Arg Ser Lys Gln Asn Leu Val Pro Phe Arg Asp Ser Lys Leu 
    450                 455                 460                 


Thr Arg Val Phe Gln Gly Phe Phe Thr Gly Arg Gly Arg Ser Cys Met 
465                 470                 475                 480 


Ile Val Asn Val Asn Pro Cys Ala Ser Thr Tyr Asp Glu Thr Leu His 
                485                 490                 495     


Val Ala Lys Phe Ser Ala Ile Ala Ser Gln Leu Val His Ala Pro Pro 
            500                 505                 510         


Met Gln Leu Gly Phe Pro Ser Leu His Ser Phe Ile Lys Glu His Ser 
        515                 520                 525             


Leu Gln Val Ser Pro Ser Leu Glu Lys Gly Ala Lys Ala Asp Thr Gly 
    530                 535                 540                 


Leu Asp Asp Asp Ile Glu Asn Glu Ala Asp Ile Ser Met Tyr Gly Lys 
545                 550                 555                 560 


Glu Glu Leu Leu Gln Val Val Glu Ala Met Lys Thr Leu Leu Leu Lys 
                565                 570                 575     


Glu Arg Gln Glu Lys Leu Gln Leu Glu Met His Leu Arg Asp Glu Ile 
            580                 585                 590         


Cys Asn Glu Met Val Glu Gln Met Gln Gln Arg Glu Gln Trp Cys Ser 
        595                 600                 605             


Glu His Leu Asp Thr Gln Lys Glu Leu Leu Glu Glu Met Tyr Glu Glu 
    610                 615                 620                 


Lys Leu Asn Ile Leu Lys Glu Ser Leu Thr Ser Phe Tyr Gln Glu Glu 
625                 630                 635                 640 


Ile Gln Glu Arg Asp Glu Lys Ile Glu Glu Leu Glu Ala Leu Leu Gln 
                645                 650                 655     


Glu Ala Arg Gln Gln Ser Val Ala His Gln Gln Ser Gly Ser Glu Leu 
            660                 665                 670         


Ala Leu Arg Arg Ser Gln Arg Leu Ala Ala Ser Ala Ser Thr Gln Gln 
        675                 680                 685             


Leu Gln Glu Val Lys Ala Lys Leu Gln Gln Cys Lys Ala Glu Leu Asn 
    690                 695                 700                 


Ser Thr Thr Glu Glu Leu His Lys Tyr Gln Lys Met Leu Glu Pro Pro 
705                 710                 715                 720 


Pro Ser Ala Lys Pro Phe Thr Ile Asp Val Asp Lys Lys Leu Glu Glu 
                725                 730                 735     


Gly Gln Lys Asn Ile Arg Leu Leu Arg Thr Glu Leu Gln Lys Leu Gly 
            740                 745                 750         


Glu Ser Leu Gln Ser Ala Glu Arg Ala Cys Cys His Ser Thr Gly Ala 
        755                 760                 765             


Gly Lys Leu Arg Gln Ala Leu Thr Thr Cys Asp Asp Ile Leu Ile Lys 
    770                 775                 780                 


Gln Asp Gln Thr Leu Ala Glu Leu Gln Asn Asn Met Val Leu Val Lys 
785                 790                 795                 800 


Leu Asp Leu Arg Lys Lys Ala Ala Cys Ile Ala Glu Gln Tyr His Thr 
                805                 810                 815     


Val Leu Lys Leu Gln Gly Gln Val Ser Ala Lys Lys Arg Leu Gly Thr 
            820                 825                 830         


Asn Gln Glu Asn Gln Gln Pro Asn Gln Gln Pro Pro Gly Lys Lys Pro 
        835                 840                 845             


Phe Leu Arg Asn Leu Leu Pro Arg Thr Pro Thr Cys Gln Ser Ser Thr 
    850                 855                 860                 


Asp Cys Ser Pro Tyr Ala Arg Ile Leu Arg Ser Arg Arg Ser Pro Leu 
865                 870                 875                 880 


Leu Lys Ser Gly Pro Phe Gly Lys Lys Tyr 
                885                 890 


<210>  2121
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KI20A__Homo_sapiens__AAC83230

<400>  2121
augucgcaag ggauccuuuc uccgccagcg ggcuugcugu ccgaugacga ugucguaguu       60

ucucccaugu uugaguccac agcugcagau uuggggucug ugguacgcaa gaaccugcua      120

ucagacugcu cugucgucuc uaccucccua gaggacaagc agcagguucc aucugaggac      180

aguauggaga aggugaaagu auacuugagg guuaggcccu uguuaccuuc agaguuggaa      240

cgacaggaag aucaggguug uguccguauu gagaaugugg agacccuugu ucuacaagca      300

cccaaggacu cguuugcccu gaagagcaau gaacggggaa uuggccaagc cacacacagg      360

uucaccuuuu cccagaucuu ugggccagaa gugggacagg cauccuucuu caaccuaacu      420

gugaaggaga ugguaaagga uguacucaaa gggcagaacu ggcucaucua uacauaugga      480

gucacuaacu cagggaaaac ccacacgauu caagguacca ucaaggaugg agggauucuc      540

ccccgguccc uggcgcugau cuucaauagc cuccaaggcc aacuucaucc aacaccugau      600

cugaagcccu ugcucuccaa ugagguaauc uggcuagaca gcaagcagau ccgacaggag      660

gaaaugaaga agcugucccu gcuaaaugga ggccuccaag aggaggagcu guccacuucc      720

uugaagagga gugucuacau cgaaagucgg auagguacca gcaccagcuu cgacaguggc      780

auugcugggc ucucuucuau cagucagugu accagcagua gccagcugga ugaaacaagu      840

caucgauggg cacagccaga cacugcccca cuaccugucc cggcaaacau ucgcuucucc      900

aucuggaucu cauucuuuga gaucuacaac gaacugcuuu augaccuauu agaaccgccu      960

agccaacagc gcaagaggca gacuuugcgg cuaugcgagg aucaaaaugg caaucccuau     1020

gugaaagauc ucaacuggau ucaugugcaa gaugcugagg aggccuggaa gcuccuaaaa     1080

gugggucgua agaaccagag cuuugccagc acccaccuca accagaacuc cagccgcagu     1140

cacagcaucu ucucaaucag gauccuacac cuucaggggg aaggagauau aguccccaag     1200

aucagcgagc ugucacucug ugaucuggcu ggcucagagc gcugcaaaga ucagaagagu     1260

ggugaacggu ugaaggaagc aggaaacauu aacaccucuc uacacacccu gggccgcugu     1320

auugcugccc uucgucaaaa ccagcagaac cggucaaagc agaaccuggu ucccuuccgu     1380

gacagcaagu ugacucgagu guuccaaggu uucuucacag gccgaggccg uuccugcaug     1440

auugucaaug ugaaucccug ugcaucuacc uaugaugaaa cucuucaugu ggccaaguuc     1500

ucagccauug cuagccagcu ugugcaugcc ccaccuaugc aacugggauu cccaucccug     1560

cacucguuca ucaaggaaca uagucuucag guauccccca gcuuagagaa aggggcuaag     1620

gcagacacag gccuugauga ugauauugaa aaugaagcug acaucuccau guauggcaaa     1680

gaggagcucc uacaaguugu ggaagccaug aagacacugc uuuugaagga acgacaggaa     1740

aagcuacagc uggagaugca ucuccgagau gaaauuugca augagauggu agaacagaug     1800

caacagcggg aacaguggug cagugaacau uuggacaccc aaaaggaacu auuggaggaa     1860

auguaugaag aaaaacuaaa uauccucaag gagucacuga caaguuuuua ccaagaagag     1920

auucaggagc gggaugaaaa gauugaagag cuagaagcuc ucuugcagga agccagacaa     1980

cagucagugg cccaucagca aucagggucu gaauuggccc uacggcgguc acaaagguug     2040

gcagcuucug ccuccaccca gcagcuucag gagguuaaag cuaaauuaca gcagugcaaa     2100

gcagagcuaa acucuaccac ugaagaguug cauaaguauc agaaaauguu agaaccacca     2160

cccucagcca agcccuucac cauugaugug gacaagaagu uagaagaggg ccagaagaau     2220

auaaggcugu ugcggacaga gcuucagaaa cuuggugagu cucuccaauc agcagagaga     2280

gcuuguugcc acagcacugg ggcaggaaaa cuucgucaag ccuugaccac uugugaugac     2340

aucuuaauca aacaggacca gacucuggcu gaacugcaga acaacauggu gcuagugaaa     2400

cuggaccuuc ggaagaaggc agcauguauu gcugagcagu aucauacugu guugaaacuc     2460

caaggccagg uuucugccaa aaagcgccuu gguaccaacc aggaaaauca gcaaccaaac     2520

caacaaccac cagggaagaa accauuccuu cgaaauuuac uuccccgaac accaaccugc     2580

caaagcucaa cagacugcag cccuuaugcc cggauccuac gcucacggcg uuccccuuua     2640

cucaaaucug ggccuuuugg caaaaaguac uaa                                  2673


<210>  2122
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KI20A__Homo_sapiens__AAC83230

<400>  2122
augagccagg gcauccuguc cccgcccgcc gggcuccuga gcgacgacga cguggucgug       60

ucccccaugu ucgagagcac cgccgcggac cugggcuccg ugguccgcaa gaaccuccug      120

agcgacugcu ccguggugag caccucccug gaggacaagc agcagguccc cagcgaggac      180

uccauggaga aggugaaggu guaccuccgg guccgccccc ugcugccgag cgagcucgag      240

cggcaggagg accaggggug cgugcgcauc gagaacgugg agacgcuggu ccugcaggcc      300

cccaaggacu ccuucgcccu caagagcaac gagcggggca ucgggcaggc cacccaccgc      360

uucaccuucu cccagaucuu cggccccgag gugggccagg ccagcuucuu caaccugacc      420

gugaaggaga uggucaagga cgugcugaag gggcagaacu ggcucaucua cacguacggc      480

gugaccaacu ccgggaagac ccacaccauc cagggcacga ucaaggacgg gggcauccug      540

ccccggagcc uggcgcucau cuucaacucc cugcagggcc agcugcaccc gacccccgac      600

cucaagcccc ugcugagcaa cgaggucauc uggcucgaca gcaagcagau ccgccaggag      660

gagaugaaga agcugucccu gcucaacggg ggccugcagg aggaggagcu gagcaccucc      720

cucaagcgga gcguguacau cgagucccgc aucgggacca gcacguccuu cgacagcggc      780

aucgccggcc uguccagcau cucccagugc accagcucca gccagcugga cgagaccucc      840

caccgguggg cccagcccga caccgccccg cuccccgugc ccgcgaacau ccgcuucagc      900

aucuggaucu ccuucuucga gaucuacaac gagcugcugu acgaccuccu ggagcccccg      960

agccagcagc ggaagcgcca gacgcugcgg cucugcgagg accagaacgg gaaccccuac     1020

gucaaggacc ugaacuggau ccacgugcag gacgccgagg aggccuggaa gcugcucaag     1080

gugggccgca agaaccaguc cuucgccagc acccaccuga accagaacag cucccggagc     1140

cacuccaucu ucagcauccg cauccugcac cuccaggggg agggcgacau cguccccaag     1200

aucuccgagc ugagccugug cgaccucgcc ggguccgagc ggugcaagga ccagaagucc     1260

ggcgagcgcc ugaaggaggc gggcaacauc aacaccuccc ugcacacccu ggggcggugc     1320

aucgccgccc uccgccagaa ccagcagaac cgcagcaagc agaaccuggu gcccuuccgg     1380

gacuccaagc ugacgcgcgu cuuccagggc uucuucaccg ggcggggccg cagcugcaug     1440

aucgugaacg ugaacccgug cgccuccacc uacgacgaga cccuccacgu cgccaaguuc     1500

agcgcgaucg ccucccagcu ggugcacgcc ccgcccaugc agcugggguu ccccagccuc     1560

cacuccuuca ucaaggagca cagccuccag gugagccccu cccuggagaa gggcgccaag     1620

gccgacacgg gccuggacga cgacaucgag aacgaggcgg acaucagcau guacgggaag     1680

gaggagcugc ugcaggucgu ggaggccaug aagacccucc ugcugaagga gcggcaggag     1740

aagcuccagc uggagaugca ccuccgcgac gagaucugca acgagauggu ggagcagaug     1800

cagcagcggg agcaguggug cuccgagcac cuggacaccc agaaggagcu gcuggaggag     1860

auguacgagg agaagcucaa cauccugaag gagagccuga ccuccuucua ccaggaggag     1920

auccaggagc gcgacgagaa gaucgaggag cucgaggccc ugcugcagga ggcccggcag     1980

cagagcgucg cccaccagca guccggcagc gagcucgcgc ugcgccgguc ccagcgccug     2040

gccgccagcg ccuccacgca gcagcuccag gaggugaagg cgaagcugca gcagugcaag     2100

gccgagcuga acagcaccac cgaggagcuc cacaaguacc agaagaugcu ggagcccccg     2160

cccuccgcca agcccuucac caucgacgug gacaagaagc uggaggaggg gcagaagaac     2220

auccggcucc ugcgcacgga gcugcagaag cucggcgaga gccugcaguc cgccgagcgg     2280

gccugcugcc acagcaccgg ggcgggcaag cugcgccagg cccucacgac cugcgacgac     2340

auccugauca agcaggacca gacccuggcc gagcuccaga acaacauggu ccuggugaag     2400

cuggaccucc ggaagaaggc cgccugcauc gcggagcagu accacaccgu gcugaagcug     2460

cagggccagg ucuccgccaa gaagcgccuc gggaccaacc aggagaacca gcagcccaac     2520

cagcagcccc cgggcaagaa gcccuuccug cggaaccugc ucccccgcac cccgaccugc     2580

cagagcucca cggacugcag ccccuacgcc cgcauccugc ggagccgccg gagcccccug     2640

cucaagagcg ggcccuucgg caagaaguac uga                                  2673


<210>  2123
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KI20A__Homo_sapiens__AAC83230

<400>  2123
augucccagg gcauccucuc cccccccgcc ggccuccucu ccgacgacga cgucgucguc       60

ucccccaugu ucgaguccac cgccgccgac cucggcuccg ucguccgcaa gaaccuccuc      120

uccgacugcu ccgucgucuc caccucccuc gaggacaagc agcagguccc cuccgaggac      180

uccauggaga aggucaaggu cuaccuccgc guccgccccc uccuccccuc cgagcucgag      240

cgccaggagg accagggcug cguccgcauc gagaacgucg agacccucgu ccuccaggcc      300

cccaaggacu ccuucgcccu caaguccaac gagcgcggca ucggccaggc cacccaccgc      360

uucaccuucu cccagaucuu cggccccgag gucggccagg ccuccuucuu caaccucacc      420

gucaaggaga uggucaagga cguccucaag ggccagaacu ggcucaucua caccuacggc      480

gucaccaacu ccggcaagac ccacaccauc cagggcacca ucaaggacgg cggcauccuc      540

ccccgcuccc ucgcccucau cuucaacucc cuccagggcc agcuccaccc cacccccgac      600

cucaagcccc uccucuccaa cgaggucauc uggcucgacu ccaagcagau ccgccaggag      660

gagaugaaga agcucucccu ccucaacggc ggccuccagg aggaggagcu cuccaccucc      720

cucaagcgcu ccgucuacau cgagucccgc aucggcaccu ccaccuccuu cgacuccggc      780

aucgccggcc ucuccuccau cucccagugc accuccuccu cccagcucga cgagaccucc      840

caccgcuggg cccagcccga caccgccccc cuccccgucc ccgccaacau ccgcuucucc      900

aucuggaucu ccuucuucga gaucuacaac gagcuccucu acgaccuccu cgagcccccc      960

ucccagcagc gcaagcgcca gacccuccgc cucugcgagg accagaacgg caaccccuac     1020

gucaaggacc ucaacuggau ccacguccag gacgccgagg aggccuggaa gcuccucaag     1080

gucggccgca agaaccaguc cuucgccucc acccaccuca accagaacuc cucccgcucc     1140

cacuccaucu ucuccauccg cauccuccac cuccagggcg agggcgacau cguccccaag     1200

aucuccgagc ucucccucug cgaccucgcc ggcuccgagc gcugcaagga ccagaagucc     1260

ggcgagcgcc ucaaggaggc cggcaacauc aacaccuccc uccacacccu cggccgcugc     1320

aucgccgccc uccgccagaa ccagcagaac cgcuccaagc agaaccucgu ccccuuccgc     1380

gacuccaagc ucacccgcgu cuuccagggc uucuucaccg gccgcggccg cuccugcaug     1440

aucgucaacg ucaaccccug cgccuccacc uacgacgaga cccuccacgu cgccaaguuc     1500

uccgccaucg ccucccagcu cguccacgcc ccccccaugc agcucggcuu ccccucccuc     1560

cacuccuuca ucaaggagca cucccuccag gucucccccu cccucgagaa gggcgccaag     1620

gccgacaccg gccucgacga cgacaucgag aacgaggccg acaucuccau guacggcaag     1680

gaggagcucc uccaggucgu cgaggccaug aagacccucc uccucaagga gcgccaggag     1740

aagcuccagc ucgagaugca ccuccgcgac gagaucugca acgagauggu cgagcagaug     1800

cagcagcgcg agcaguggug cuccgagcac cucgacaccc agaaggagcu ccucgaggag     1860

auguacgagg agaagcucaa cauccucaag gagucccuca ccuccuucua ccaggaggag     1920

auccaggagc gcgacgagaa gaucgaggag cucgaggccc uccuccagga ggcccgccag     1980

caguccgucg cccaccagca guccggcucc gagcucgccc uccgccgcuc ccagcgccuc     2040

gccgccuccg ccuccaccca gcagcuccag gaggucaagg ccaagcucca gcagugcaag     2100

gccgagcuca acuccaccac cgaggagcuc cacaaguacc agaagaugcu cgagcccccc     2160

cccuccgcca agcccuucac caucgacguc gacaagaagc ucgaggaggg ccagaagaac     2220

auccgccucc uccgcaccga gcuccagaag cucggcgagu cccuccaguc cgccgagcgc     2280

gccugcugcc acuccaccgg cgccggcaag cuccgccagg cccucaccac cugcgacgac     2340

auccucauca agcaggacca gacccucgcc gagcuccaga acaacauggu ccucgucaag     2400

cucgaccucc gcaagaaggc cgccugcauc gccgagcagu accacaccgu ccucaagcuc     2460

cagggccagg ucuccgccaa gaagcgccuc ggcaccaacc aggagaacca gcagcccaac     2520

cagcagcccc ccggcaagaa gcccuuccuc cgcaaccucc ucccccgcac ccccaccugc     2580

caguccucca ccgacugcuc ccccuacgcc cgcauccucc gcucccgccg cuccccccuc     2640

cucaaguccg gccccuucgg caagaaguac uga                                  2673


<210>  2124
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KI20A__Homo_sapiens__AAC83230

<400>  2124
augagccagg gcauccuguc ucccccugcc gggcuccuuu ccgacgauga cguggucguu       60

ucaccaaugu ucgagaguac cgcugcagau cugggaagcg ugguaagaaa gaacuuguua      120

uccgacugcu cuguggucuc gacaucacug gaagauaaac aacaggugcc gagcgaggac      180

aguauggaaa agguuaaagu guaccuaagg guccggcccc uccugccuuc cgagcuugaa      240

cgccaggagg aucaggguug ugugcgaauu gagaauguag aaacucuggu uuugcaagcc      300

ccaaaggacu cuuuugcgcu caaaagcaac gagcguggca uagggcaggc uacgcacaga      360

uucaccuuuu cccagaucuu cggacccgaa gugggccagg ccucauuuuu caaucugaca      420

gucaaggaga uggugaagga ugugcugaaa ggucaaaacu ggcucauuua uacuuacggg      480

gucaccaaua guggaaagac acauaccauc cagggcacua uuaaagacgg cgggaucuua      540

ccuaggagcc uggcacuuau auuuaacucu uugcagggac agcugcaccc aacacccgau      600

cuaaagccuc uccuguccaa ugagguuauc uggcuugacu caaaacaaau ucggcaggaa      660

gagaugaaga agcugagcuu gcucaacggu ggccugcagg aagaggaauu aaguaccucu      720

cugaaacgcu ccguguauau cgagagcaga auugggacgu cgacuucuuu cgauuccgga      780

aucgccggcc ucucaaguau aagccaaugc accuccucua gccagcuuga cgagacauca      840

cauagguggg cucagccaga cacugcaccg cugcccguac cugccaauau ucgguuuagu      900

aucuggauuu ccuucuuuga aaucuacaac gaguugcuau augaucugcu cgaaccaccc      960

agccagcaac gcaagcgaca gacccugaga cuuugugagg accagaaugg uaacccuuac     1020

gugaaagauc ugaauuggau ccacguccag gacgcugaag aggccuggaa guugcucaaa     1080

guggggagga agaaccaauc uuucgcguca acacaucuga aucagaacag uagccggucc     1140

cacucuauau uuucgauucg uaucuuacau cugcagggag agggcgauau uguuccaaaa     1200

aucagcgaac uaucccucug cgaccuggca ggcucagagc gcuguaagga ucagaagagu     1260

ggggaaagac uuaaagaggc cggaaacaua aauaccucuu ugcacacgcu ggguaggugc     1320

auugcugccc uccggcaaaa ccagcagaau cgaagcaagc agaaccuggu gcccuuccgc     1380

gacuccaaac uuacuagagu cuuccaaggc uuuuucacag ggaggggacg gucauguaug     1440

aucgugaaug uaaacccgug cgcaagcacc uaugaugaaa cucugcacgu ugcuaaguuu     1500

ucugccaucg cgucccaguu ggugcaugcc ccucccaugc agcucggcuu cccaagucug     1560

cacagcuuua uuaaagagca cucuuuacaa gucuccccuu cacuggagaa gggugcaaag     1620

gcugacacag ggcuagauga cgacaucgaa aaugaggccg auauuaguau guacggcaaa     1680

gaagaacucc uucagguggu cgaggcuaug aagacccugu ugcugaaaga acgccaggag     1740

aagcuccagc uggaaaugca uuuaagagac gagauaugua acgaaauggu ggagcaaaug     1800

cagcagaggg agcaguggug cagcgaacac cuggauacgc aaaaagagcu uuuggaagag     1860

auguacgaag agaagcucaa uauccugaag gagucgcuaa ccuccuucua ucaggaagag     1920

auucaggaac gugacgagaa aaucgaggag cuggaggccc uccugcagga agcacggcaa     1980

cagucuguug cccaucagca aagcggauca gagcuugcuu ugcgaagaag ucagaggcug     2040

gcggcauccg ccucuacaca gcaguuacaa gaagugaagg cuaaacucca gcaguguaag     2100

gccgagcuga acagcacuac cgaggaacuu cacaaauacc agaagaugcu ggagccccca     2160

cccuccgcaa agccuuuuac aaucgaugua gacaaaaagu uggaagaggg ccagaaaaau     2220

auucgccucc ugcggacuga acuacaaaag cugggggagu cacuccagag cgccgagaga     2280

gcuugcugcc auaguaccgg agccgguaaa cugaggcagg cacuuacaac cugugaugac     2340

auauugauca agcaagauca gacucuggcg gaauuacaga acaauauggu ccucgugaaa     2400

cuggaccuuc gcaagaaggc ugccugcauu gcagagcagu aucacacggu ucugaaacua     2460

caaggccagg ugucugccaa gaaacgacuc gggacaaacc aggaaaauca acagccaaac     2520

cagcagccgc ccggaaagaa accuuuccug cggaacuugc ugccacguac ccccacuugu     2580

caauccagca ccgauugcuc gccuuacgcu agaaucuuaa ggucacgccg gucuccacuc     2640

cugaagagug gccccuuugg uaagaaauau uga                                  2673


<210>  2125
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KI20A__Homo_sapiens__AAC83230

<400>  2125
augagccagg gcauccugag cccccccgcc ggccugcuga gcgacgacga cgugguggug       60

agccccaugu ucgagagcac cgccgccgac cugggcagcg uggugagaaa gaaccugcug      120

agcgacugca gcguggugag caccagccug gaggacaagc agcaggugcc cagcgaggac      180

agcauggaga aggugaaggu guaccugaga gugagacccc ugcugcccag cgagcuggag      240

agacaggagg accagggcug cgugagaauc gagaacgugg agacccuggu gcugcaggcc      300

cccaaggaca gcuucgcccu gaagagcaac gagagaggca ucggccaggc cacccacaga      360

uucaccuuca gccagaucuu cggccccgag gugggccagg ccagcuucuu caaccugacc      420

gugaaggaga uggugaagga cgugcugaag ggccagaacu ggcugaucua caccuacggc      480

gugaccaaca gcggcaagac ccacaccauc cagggcacca ucaaggacgg cggcauccug      540

cccagaagcc uggcccugau cuucaacagc cugcagggcc agcugcaccc cacccccgac      600

cugaagcccc ugcugagcaa cgaggugauc uggcuggaca gcaagcagau cagacaggag      660

gagaugaaga agcugagccu gcugaacggc ggccugcagg aggaggagcu gagcaccagc      720

cugaagagaa gcguguacau cgagagcaga aucggcacca gcaccagcuu cgacagcggc      780

aucgccggcc ugagcagcau cagccagugc accagcagca gccagcugga cgagaccagc      840

cacagauggg cccagcccga caccgccccc cugcccgugc ccgccaacau cagauucagc      900

aucuggauca gcuucuucga gaucuacaac gagcugcugu acgaccugcu ggagcccccc      960

agccagcaga gaaagagaca gacccugaga cugugcgagg accagaacgg caaccccuac     1020

gugaaggacc ugaacuggau ccacgugcag gacgccgagg aggccuggaa gcugcugaag     1080

gugggcagaa agaaccagag cuucgccagc acccaccuga accagaacag cagcagaagc     1140

cacagcaucu ucagcaucag aauccugcac cugcagggcg agggcgacau cgugcccaag     1200

aucagcgagc ugagccugug cgaccuggcc ggcagcgaga gaugcaagga ccagaagagc     1260

ggcgagagac ugaaggaggc cggcaacauc aacaccagcc ugcacacccu gggcagaugc     1320

aucgccgccc ugagacagaa ccagcagaac agaagcaagc agaaccuggu gcccuucaga     1380

gacagcaagc ugaccagagu guuccagggc uucuucaccg gcagaggcag aagcugcaug     1440

aucgugaacg ugaaccccug cgccagcacc uacgacgaga cccugcacgu ggccaaguuc     1500

agcgccaucg ccagccagcu ggugcacgcc ccccccaugc agcugggcuu ccccagccug     1560

cacagcuuca ucaaggagca cagccugcag gugagcccca gccuggagaa gggcgccaag     1620

gccgacaccg gccuggacga cgacaucgag aacgaggccg acaucagcau guacggcaag     1680

gaggagcugc ugcagguggu ggaggccaug aagacccugc ugcugaagga gagacaggag     1740

aagcugcagc uggagaugca ccugagagac gagaucugca acgagauggu ggagcagaug     1800

cagcagagag agcaguggug cagcgagcac cuggacaccc agaaggagcu gcuggaggag     1860

auguacgagg agaagcugaa cauccugaag gagagccuga ccagcuucua ccaggaggag     1920

auccaggaga gagacgagaa gaucgaggag cuggaggccc ugcugcagga ggccagacag     1980

cagagcgugg cccaccagca gagcggcagc gagcuggccc ugagaagaag ccagagacug     2040

gccgccagcg ccagcaccca gcagcugcag gaggugaagg ccaagcugca gcagugcaag     2100

gccgagcuga acagcaccac cgaggagcug cacaaguacc agaagaugcu ggagcccccc     2160

cccagcgcca agcccuucac caucgacgug gacaagaagc uggaggaggg ccagaagaac     2220

aucagacugc ugagaaccga gcugcagaag cugggcgaga gccugcagag cgccgagaga     2280

gccugcugcc acagcaccgg cgccggcaag cugagacagg cccugaccac cugcgacgac     2340

auccugauca agcaggacca gacccuggcc gagcugcaga acaacauggu gcuggugaag     2400

cuggaccuga gaaagaaggc cgccugcauc gccgagcagu accacaccgu gcugaagcug     2460

cagggccagg ugagcgccaa gaagagacug ggcaccaacc aggagaacca gcagcccaac     2520

cagcagcccc ccggcaagaa gcccuuccug agaaaccugc ugcccagaac ccccaccugc     2580

cagagcagca ccgacugcag ccccuacgcc agaauccuga gaagcagaag aagcccccug     2640

cugaagagcg gccccuucgg caagaaguac uga                                  2673


<210>  2126
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KI20A__Homo_sapiens__AAC83230

<400>  2126
augagccagg gcauccuguc cccucccgcc gggcugcugu cugacgauga cguggucguu       60

agcccgaugu ucgaguccac cgcugccgau cuuggaucug uggugagaaa gaaccugcuc      120

agcgacugcu ccgucguguc uacaagccug gaagauaaac aacagguucc cuccgaggac      180

agcauggaaa aggugaaagu cuaccuucgg gugcgcccuc ugcuccccuc ugagcuggaa      240

agacaggagg aucagggcug uguucggauu gagaaugugg aaacgcuggu ccuccaagcg      300

ccuaaggacu ccuuugcucu gaaaagcaac gagcgcggga ucggacaggc cacccacaga      360

uucacauuuu cucagauuuu cggccccgaa guggggcagg ccuccuuuuu caaucuuacc      420

gugaaggaga uggucaagga uguucugaaa ggacaaaacu ggcucaucua uacauacggc      480

gugaccaaua gcggcaagac acauaccauu caggggacga ucaaagacgg aggcauccug      540

ccucggucuc uugcucugau uuuuaacucc cuccaggggc agcugcaccc gacccccgau      600

cugaagccuc uccugagcaa ugaggugauc uggcuugacu ccaaacaaau ucgccaggaa      660

gagaugaaga agcugucucu ccugaacgga ggccuucagg aagaggaacu gagcacaucc      720

cucaaaagaa gcgucuauau cgagucucgg auugggaccu ccacauccuu cgauucugga      780

aucgccggcc ugagcuccau uucucaaugc accagcucca gccagcugga cgagacgucu      840

caucgcuggg cucagcccga cacagccccu cuccccgugc cggcgaauau cagauuuucc      900

aucuggauua gcuucuuuga aaucuacaac gagcugcuuu augaucugcu cgaaccuccc      960

ucucagcaac ggaagcgcca gacccugaga cuuugugagg accagaaugg caacccuuac     1020

guuaaagauc ugaauuggau ucacgugcag gacgccgaag aggcuuggaa gcuccugaaa     1080

gucgggcgga agaaccaauc cuucgccagc acacaucuga aucagaacuc cucucgcagc     1140

cacuccaucu uuucuauuag aauccuccau cugcagggag agggcgauau cgugcccaaa     1200

auuagcgaac uuucccugug cgaccucgcu gggagcgagc gguguaagga ucagaagucu     1260

ggagaaagac ugaaagaggc cggcaacauc aauaccuccc ugcacacccu ugggcgcugc     1320

auugcggccc uccggcaaaa ccagcagaau agaagcaagc agaaccuggu ucccuuccgc     1380

gacucuaaac ugacacgggu guuccaagga uuuuucacgg gcagaggccg cuccuguaug     1440

aucgucaaug ugaacccuug cgcuagcacc uaugaugaaa cacuccacgu cgccaaguuu     1500

ucugcuauug ccagccagcu ggugcaugcc ccgcccaugc agcuuggguu cccuucccug     1560

cacagcuuua ucaaagagca cucucuccaa guuuccccca gccuggagaa gggagcuaag     1620

gcggacaccg gccuggauga cgacaucgaa aaugaggccg auauuuccau guacgggaaa     1680

gaagaacuuc uccagguggu cgaggcuaug aagacacugc ugcucaaaga acggcaggag     1740

aagcugcagc uugaaaugca ucugagagac gagaucugua acgaaauggu ggagcaaaug     1800

cagcagcgcg agcaguggug cucugaacac cucgauaccc aaaaagagcu gcuggaagag     1860

auguacgaag agaaacuuaa uauucucaag gagagccuga cguccuucua ucaggaagag     1920

auccaggaac gggacgagaa aauugaggag cuggaggccc uccugcagga agccagacaa     1980

cagucuguug cucaucagca aagcggaucc gagcuugccc ugcgccgguc ucagagacuc     2040

gcggcuagcg ccuccacaca gcagcugcaa gaagugaagg ccaaacugca gcaguguaag     2100

gcugagcuua acagcaccac cgaggaacuc cacaaauacc agaagaugcu ggagccuccc     2160

ccgucugcca agccuuuuac aaucgauguc gacaaaaagc uggaagaggg ccaaaagaau     2220

auucggcucc ugcgcaccga acuucagaag cugggggagu cccuccagag cgcugagaga     2280

gccugcugcc auucuacagg cgcgggaaaa cugcggcagg cccugacgac cugugaugac     2340

auccuuauca agcaagauca gacacuggcu gaacuccaga acaauauggu gcuggugaaa     2400

cucgaccuga gaaagaaggc cgcuugcauu gccgagcagu aucacaccgu ucuuaaacug     2460

caaggccagg ucuccgcgaa gaaacgccuc gggacaaacc aggaaaauca acagcccaac     2520

cagcagccuc ccggaaagaa accuuuccug cggaaccugc uucccagaac cccgacgugu     2580

caaagcucua ccgauugcuc cccuuacgcc cgcauccuga gaagccggcg cagcccccuc     2640

cucaagagcg gccccuuugg gaagaaauau uga                                  2673


<210>  2127
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KIAA0205__Homo_sapiens__Q92604

<400>  2127

Met Ala Ile Thr Leu Glu Glu Ala Pro Trp Leu Gly Trp Leu Leu Val 
1               5                   10                  15      


Lys Ala Leu Met Arg Phe Ala Phe Met Val Val Asn Asn Leu Val Ala 
            20                  25                  30          


Ile Pro Ser Tyr Ile Cys Tyr Val Ile Ile Leu Gln Pro Leu Arg Val 
        35                  40                  45              


Leu Asp Ser Lys Arg Phe Trp Tyr Ile Glu Gly Ile Met Tyr Lys Trp 
    50                  55                  60                  


Leu Leu Gly Met Val Ala Ser Trp Gly Trp Tyr Ala Gly Tyr Thr Val 
65                  70                  75                  80  


Met Glu Trp Gly Glu Asp Ile Lys Ala Val Ser Lys Asp Glu Ala Val 
                85                  90                  95      


Met Leu Val Asn His Gln Ala Thr Gly Asp Val Cys Thr Leu Met Met 
            100                 105                 110         


Cys Leu Gln Asp Lys Gly Leu Val Val Ala Gln Met Met Trp Leu Met 
        115                 120                 125             


Asp His Ile Phe Lys Tyr Thr Asn Phe Gly Ile Val Ser Leu Val His 
    130                 135                 140                 


Gly Asp Phe Phe Ile Arg Gln Gly Arg Ser Tyr Arg Asp Gln Gln Leu 
145                 150                 155                 160 


Leu Leu Leu Lys Lys His Leu Glu Asn Asn Tyr Arg Ser Arg Asp Arg 
                165                 170                 175     


Lys Trp Ile Val Leu Phe Pro Glu Gly Gly Phe Leu Arg Lys Arg Arg 
            180                 185                 190         


Glu Thr Ser Gln Ala Phe Ala Lys Lys Asn Asn Leu Pro Phe Leu Thr 
        195                 200                 205             


Asn Val Thr Leu Pro Arg Ser Gly Ala Thr Lys Ile Ile Leu Asn Ala 
    210                 215                 220                 


Leu Val Ala Gln Gln Lys Asn Gly Ser Pro Ala Gly Gly Asp Ala Lys 
225                 230                 235                 240 


Glu Leu Asp Ser Lys Ser Lys Gly Leu Gln Trp Ile Ile Asp Thr Thr 
                245                 250                 255     


Ile Ala Tyr Pro Lys Ala Glu Pro Ile Asp Ile Gln Thr Trp Ile Leu 
            260                 265                 270         


Gly Tyr Arg Lys Pro Thr Val Thr His Val His Tyr Arg Ile Phe Pro 
        275                 280                 285             


Ile Lys Asp Val Pro Leu Glu Thr Asp Asp Leu Thr Thr Trp Leu Tyr 
    290                 295                 300                 


Gln Arg Phe Val Glu Lys Glu Asp Leu Leu Ser His Phe Tyr Glu Thr 
305                 310                 315                 320 


Gly Ala Phe Pro Pro Ser Lys Gly His Lys Glu Ala Val Ser Arg Glu 
                325                 330                 335     


Met Thr Leu Ser Asn Leu Trp Ile Phe Leu Ile Gln Ser Phe Ala Phe 
            340                 345                 350         


Leu Ser Gly Tyr Met Trp Tyr Asn Ile Ile Gln Tyr Phe Tyr His Cys 
        355                 360                 365             


Leu Phe 
    370 


<210>  2128
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KIAA0205__Homo_sapiens__AAH34621

<400>  2128
auggcuauaa cuuuggaaga agcuccgugg cugggcuggc ucuuggugaa agcacugaug       60

agguuugccu ucauggucgu caacaaccug guugcuauuc cauccuacau cugcuaugua      120

auuauacuuc agccccuucg agugcuggac aguaagcggu ucugguauau cgaaggaauc      180

auguauaaau ggcuuuuagg aaugguagcu uccuggggau gguaugcugg auauacagug      240

auggaauggg gagaagauau uaaagcaguu ucaaaagaug aagcagugau guuggugaau      300

caucaggcaa caggagaugu gugcacacug augaugugcc uccaggacaa aggacugguu      360

guugcucaga ugaugugguu gauggaucau auuuuuaagu acacaaacuu uggaauuguu      420

ucucuaguuc auggagacuu cuuuauaaga cagggaagau cuuaucguga ccaacagcug      480

cugcuucuca agaagcacuu agaaaauaau uacaggagca gagaucgaaa auggauuguu      540

uuguuuccag aagggggcuu ccucaggaag aggcgagaaa caagucaggc auuugccaag      600

aaaaauaacu ugccauuucu uacaaauguu acucugccaa ggucuggggc aacaaaaauu      660

auuuugaaug cacuuguagc acaacagaaa aauggaaguc cagcaggagg agaugcuaaa      720

gaauuagaca gcaaaucaaa aggccuccag uggauaauag auacaacgau agcuuauccc      780

aaagcugaac cuauagauau ucaaaccugg auccuuggau acaggaaacc aacagucaca      840

cauguacauu acaggaucuu uccaauuaaa gauguacccc uggagacuga ugaccuuacc      900

acuuggcucu aucagcgguu uguugaaaaa gaagaccucu uaucacauuu uuaugaaaca      960

ggagcuuuuc caccuuccaa gggccauaag gaagcuguuu ccagggagau gacccucagc     1020

aacuugugga uauuucucau acagucuuuu gcauuuuugu caggcuauau gugguacaac     1080

aucauucagu auuuuuacca uugccuguuu uag                                  1113


<210>  2129
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KIAA0205__Homo_sapiens__AAH34621

<400>  2129
auggccauca cccuggagga ggcccccugg cucggcuggc ugcuggugaa ggcgcucaug       60

cgcuucgccu ucauggucgu gaacaaccug guggccaucc cgagcuacau cugcuacguc      120

aucauccugc agccccuccg ggugcuggac uccaagcgcu ucugguacau cgaggggauc      180

auguacaagu ggcugcucgg caugguggcc agcugggggu gguacgccgg cuacaccguc      240

auggaguggg gcgaggacau caaggcggug uccaaggacg aggccgugau gcuggucaac      300

caccaggcca cgggggacgu gugcacccug augaugugcc uccaggacaa gggccuggug      360

gucgcccaga ugauguggcu gauggaccac aucuucaagu acaccaacuu cgggaucgug      420

agccucgugc acggcgacuu cuucauccgg caggggcgcu ccuaccggga ccagcagcug      480

cugcuccuga agaagcaccu ggagaacaac uaccgcagcc gggaccgcaa guggaucguc      540

cucuuccccg agggcggguu ccugcggaag cgccgggaga ccucccaggc guucgccaag      600

aagaacaacc ugcccuuccu cacgaacgug acccugccgc gcagcggcgc caccaagauc      660

auccugaacg cccucguggc ccagcagaag aacggcuccc ccgccggggg cgacgcgaag      720

gagcuggaca gcaaguccaa ggggcugcag uggaucaucg acaccacgau cgccuacccc      780

aaggccgagc ccaucgacau ccagaccugg auccucggcu accggaagcc gaccgucacc      840

cacgugcacu accgcaucuu ccccaucaag gacgugcccc uggagacgga cgaccugacc      900

accuggcucu accagcgguu cgucgagaag gaggaccugc ugagccacuu cuacgagacc      960

ggcgccuucc cgcccuccaa ggggcacaag gaggcgguga gccgcgagau gacgcucucc     1020

aaccugugga ucuuccugau ccagagcuuc gccuuccucu ccggcuacau gugguacaac     1080

aucauccagu acuucuacca cugccuguuc uga                                  1113


<210>  2130
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KIAA0205__Homo_sapiens__AAH34621

<400>  2130
auggccauca cccucgagga ggcccccugg cucggcuggc uccucgucaa ggcccucaug       60

cgcuucgccu ucauggucgu caacaaccuc gucgccaucc ccuccuacau cugcuacguc      120

aucauccucc agccccuccg cguccucgac uccaagcgcu ucugguacau cgagggcauc      180

auguacaagu ggcuccucgg cauggucgcc uccuggggcu gguacgccgg cuacaccguc      240

auggaguggg gcgaggacau caaggccguc uccaaggacg aggccgucau gcucgucaac      300

caccaggcca ccggcgacgu cugcacccuc augaugugcc uccaggacaa gggccucguc      360

gucgcccaga ugauguggcu cauggaccac aucuucaagu acaccaacuu cggcaucguc      420

ucccucgucc acggcgacuu cuucauccgc cagggccgcu ccuaccgcga ccagcagcuc      480

cuccuccuca agaagcaccu cgagaacaac uaccgcuccc gcgaccgcaa guggaucguc      540

cucuuccccg agggcggcuu ccuccgcaag cgccgcgaga ccucccaggc cuucgccaag      600

aagaacaacc uccccuuccu caccaacguc acccuccccc gcuccggcgc caccaagauc      660

auccucaacg cccucgucgc ccagcagaag aacggcuccc ccgccggcgg cgacgccaag      720

gagcucgacu ccaaguccaa gggccuccag uggaucaucg acaccaccau cgccuacccc      780

aaggccgagc ccaucgacau ccagaccugg auccucggcu accgcaagcc caccgucacc      840

cacguccacu accgcaucuu ccccaucaag gacguccccc ucgagaccga cgaccucacc      900

accuggcucu accagcgcuu cgucgagaag gaggaccucc ucucccacuu cuacgagacc      960

ggcgccuucc cccccuccaa gggccacaag gaggccgucu cccgcgagau gacccucucc     1020

aaccucugga ucuuccucau ccaguccuuc gccuuccucu ccggcuacau gugguacaac     1080

aucauccagu acuucuacca cugccucuuc uga                                  1113


<210>  2131
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KIAA0205__Homo_sapiens__AAH34621

<400>  2131
auggccauca cccuggagga agcucccugg cucggcuggc uucuggugaa ggcauugaug       60

agauucgccu uuauggucgu uaacaauuua guggcgauuc cuagcuacau augcuaugua      120

aucauucugc agccacuaag ggugcucgac uccaaacggu ucugguacau cgaggggauu      180

auguauaagu ggcugcuugg aauggucgcu ucuugggguu gguacgccgg cuauacagug      240

auggaauggg gagaggauau caaagcaguu ucaaaggacg aagccgugau gcuggucaac      300

caccaagcua cuggggaugu guguacguug augaugugcc uccaggacaa aggccuggua      360

guugcacaga ugauguggcu gauggaucau auauuuaagu acaccaauuu cgguaucgug      420

agucucgucc acggggacuu uuucauucgc cagggacgaa gcuaucguga ucaacaguua      480

cugcuuuuga agaaacaucu ggagaacaau uacagaucca gggaccggaa guggaucgug      540

cuauuuccgg agggcggcuu ccuccgcaaa agaagggaaa caucucaggc cuuugcuaag      600

aaaaacaauc ugcccuuccu uacuaacgug acccugccuc ggucgggggc cacaaagauu      660

aucuugaaug cgcucgucgc acagcaaaag aacggaucac cagccggugg cgaugcuaaa      720

gagcuggaca gcaagaguaa aggguuacag uggauaauug auaccacuau cgccuacccc      780

aaggcagaac cuauugacau ccagacaugg auccugggau aucgcaaacc aaccguuacg      840

cacgugcauu accgaauuuu ucccauaaag gauguaccuc ucgagacuga cgaccuuacc      900

acauggcugu aucagagauu cguggagaaa gaagauuugc uaucccacuu uuacgagacu      960

ggcgcuuucc caccgucuaa gggucacaag gaagccguca gcagggagau gacccugucc     1020

aaucucugga ucuuccugau ucaaucauuu gcguuccuua guggguauau gugguacaac     1080

aucauacagu auuuuuacca uugucuguuc uga                                  1113


<210>  2132
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KIAA0205__Homo_sapiens__AAH34621

<400>  2132
auggccauca cccuggagga ggcccccugg cugggcuggc ugcuggugaa ggcccugaug       60

agauucgccu ucaugguggu gaacaaccug guggccaucc ccagcuacau cugcuacgug      120

aucauccugc agccccugag agugcuggac agcaagagau ucugguacau cgagggcauc      180

auguacaagu ggcugcuggg caugguggcc agcuggggcu gguacgccgg cuacaccgug      240

auggaguggg gcgaggacau caaggccgug agcaaggacg aggccgugau gcuggugaac      300

caccaggcca ccggcgacgu gugcacccug augaugugcc ugcaggacaa gggccuggug      360

guggcccaga ugauguggcu gauggaccac aucuucaagu acaccaacuu cggcaucgug      420

agccuggugc acggcgacuu cuucaucaga cagggcagaa gcuacagaga ccagcagcug      480

cugcugcuga agaagcaccu ggagaacaac uacagaagca gagacagaaa guggaucgug      540

cuguuccccg agggcggcuu ccugagaaag agaagagaga ccagccaggc cuucgccaag      600

aagaacaacc ugcccuuccu gaccaacgug acccugccca gaagcggcgc caccaagauc      660

auccugaacg cccugguggc ccagcagaag aacggcagcc ccgccggcgg cgacgccaag      720

gagcuggaca gcaagagcaa gggccugcag uggaucaucg acaccaccau cgccuacccc      780

aaggccgagc ccaucgacau ccagaccugg auccugggcu acagaaagcc caccgugacc      840

cacgugcacu acagaaucuu ccccaucaag gacgugcccc uggagaccga cgaccugacc      900

accuggcugu accagagauu cguggagaag gaggaccugc ugagccacuu cuacgagacc      960

ggcgccuucc cccccagcaa gggccacaag gaggccguga gcagagagau gacccugagc     1020

aaccugugga ucuuccugau ccagagcuuc gccuuccuga gcggcuacau gugguacaac     1080

aucauccagu acuucuacca cugccuguuc uga                                  1113


<210>  2133
<211>  1113
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KIAA0205__Homo_sapiens__AAH34621

<400>  2133
auggccauca cccuggagga agcucccugg cucggcuggc ugcuugugaa ggcccugaug       60

agauucgcgu uuauggucgu uaacaaucuc guggcuauuc cuagcuacau cugcuaugug      120

auuauccugc agccgcuucg gguccuggac uccaaacgcu ucugguacau ugaggggauc      180

auguauaagu ggcuccuggg aaugguggcc ucuuggggcu gguacgccgg guauacaguu      240

auggaauggg gagaggauau caaagcugug agcaaggacg aagccgucau gcuggugaac      300

caccaagcua cgggcgaugu uuguacccuc augaugugcc ugcaggacaa agggcuugug      360

gucgcccaga ugauguggcu gauggaucau auuuuuaagu acacaaauuu cggaaucgug      420

ucccucgugc acggcgacuu uuucauuaga cagggccggu cuuaucgcga ucaacagcug      480

cuucugcuca agaaacaucu ggagaacaau uacagaagcc gggaccgcaa guggaucguc      540

cuguuucccg aagggggauu ccucagaaaa cggcgcgaga ccucccaggc guuugccaag      600

aaaaacaauc ugccuuuccu uacaaacguu acccugccca gaucuggcgc uacaaagauu      660

auccucaaug cccugguggc ucagcaaaag aacgggagcc cugccggagg cgaugcgaaa      720

gagcuugacu ccaagagcaa agggcugcag uggauuaucg auaccacgau cgccuacccc      780

aaggcugaac cuauugacau ccagaccugg auucucggau aucggaaacc gacagugacc      840

cacguccauu accgcaucuu ucccauuaag gaugugccuc uggagacaga cgaccugacc      900

acguggcucu aucagagauu cguugagaaa gaagaucugc uuucucacuu uuacgagaca      960

ggcgccuuuc ccccuuccaa gggccacaag gaagcuguga gccgggagau gacccugucu     1020

aaucucugga ucuuccugau ccaauccuuc gccuuccuua gcggguauau gugguacaac     1080

auuauccagu auuuuuacca uugucuguuc uga                                  1113


<210>  2134
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KIF2C__Homo_sapiens__Q99661

<400>  2134

Met Ala Met Asp Ser Ser Leu Gln Ala Arg Leu Phe Pro Gly Leu Ala 
1               5                   10                  15      


Ile Lys Ile Gln Arg Ser Asn Gly Leu Ile His Ser Ala Asn Val Arg 
            20                  25                  30          


Thr Val Asn Leu Glu Lys Ser Cys Val Ser Val Glu Trp Ala Glu Gly 
        35                  40                  45              


Gly Ala Thr Lys Gly Lys Glu Ile Asp Phe Asp Asp Val Ala Ala Ile 
    50                  55                  60                  


Asn Pro Glu Leu Leu Gln Leu Leu Pro Leu His Pro Lys Asp Asn Leu 
65                  70                  75                  80  


Pro Leu Gln Glu Asn Val Thr Ile Gln Lys Gln Lys Arg Arg Ser Val 
                85                  90                  95      


Asn Ser Lys Ile Pro Ala Pro Lys Glu Ser Leu Arg Ser Arg Ser Thr 
            100                 105                 110         


Arg Met Ser Thr Val Ser Glu Leu Arg Ile Thr Ala Gln Glu Asn Asp 
        115                 120                 125             


Met Glu Val Glu Leu Pro Ala Ala Ala Asn Ser Arg Lys Gln Phe Ser 
    130                 135                 140                 


Val Pro Pro Ala Pro Thr Arg Pro Ser Cys Pro Ala Val Ala Glu Ile 
145                 150                 155                 160 


Pro Leu Arg Met Val Ser Glu Glu Met Glu Glu Gln Val His Ser Ile 
                165                 170                 175     


Arg Gly Ser Ser Ser Ala Asn Pro Val Asn Ser Val Arg Arg Lys Ser 
            180                 185                 190         


Cys Leu Val Lys Glu Val Glu Lys Met Lys Asn Lys Arg Glu Glu Lys 
        195                 200                 205             


Lys Ala Gln Asn Ser Glu Met Arg Met Lys Arg Ala Gln Glu Tyr Asp 
    210                 215                 220                 


Ser Ser Phe Pro Asn Trp Glu Phe Ala Arg Met Ile Lys Glu Phe Arg 
225                 230                 235                 240 


Ala Thr Leu Glu Cys His Pro Leu Thr Met Thr Asp Pro Ile Glu Glu 
                245                 250                 255     


His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Gln Glu 
            260                 265                 270         


Leu Ala Lys Lys Glu Ile Asp Val Ile Ser Ile Pro Ser Lys Cys Leu 
        275                 280                 285             


Leu Leu Val His Glu Pro Lys Leu Lys Val Asp Leu Thr Lys Tyr Leu 
    290                 295                 300                 


Glu Asn Gln Ala Phe Cys Phe Asp Phe Ala Phe Asp Glu Thr Ala Ser 
305                 310                 315                 320 


Asn Glu Val Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Gln Thr Ile 
                325                 330                 335     


Phe Glu Gly Gly Lys Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser 
            340                 345                 350         


Gly Lys Thr His Thr Met Gly Gly Asp Leu Ser Gly Lys Ala Gln Asn 
        355                 360                 365             


Ala Ser Lys Gly Ile Tyr Ala Met Ala Ser Arg Asp Val Phe Leu Leu 
    370                 375                 380                 


Lys Asn Gln Pro Cys Tyr Arg Lys Leu Gly Leu Glu Val Tyr Val Thr 
385                 390                 395                 400 


Phe Phe Glu Ile Tyr Asn Gly Lys Leu Phe Asp Leu Leu Asn Lys Lys 
                405                 410                 415     


Ala Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val 
            420                 425                 430         


Gly Leu Gln Glu His Leu Val Asn Ser Ala Asp Asp Val Ile Lys Met 
        435                 440                 445             


Ile Asp Met Gly Ser Ala Cys Arg Thr Ser Gly Gln Thr Phe Ala Asn 
    450                 455                 460                 


Ser Asn Ser Ser Arg Ser His Ala Cys Phe Gln Ile Ile Leu Arg Ala 
465                 470                 475                 480 


Lys Gly Arg Met His Gly Lys Phe Ser Leu Val Asp Leu Ala Gly Asn 
                485                 490                 495     


Glu Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Met Glu 
            500                 505                 510         


Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg 
        515                 520                 525             


Ala Leu Gly Gln Asn Lys Ala His Thr Pro Phe Arg Glu Ser Lys Leu 
    530                 535                 540                 


Thr Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys 
545                 550                 555                 560 


Met Ile Ala Thr Ile Ser Pro Gly Ile Ser Ser Cys Glu Tyr Thr Leu 
                565                 570                 575     


Asn Thr Leu Arg Tyr Ala Asp Arg Val Lys Glu Leu Ser Pro His Ser 
            580                 585                 590         


Gly Pro Ser Gly Glu Gln Leu Ile Gln Met Glu Thr Glu Glu Met Glu 
        595                 600                 605             


Ala Cys Ser Asn Gly Ala Leu Ile Pro Gly Asn Leu Ser Lys Glu Glu 
    610                 615                 620                 


Glu Glu Leu Ser Ser Gln Met Ser Ser Phe Asn Glu Ala Met Thr Gln 
625                 630                 635                 640 


Ile Arg Glu Leu Glu Glu Lys Ala Met Glu Glu Leu Lys Glu Ile Ile 
                645                 650                 655     


Gln Gln Gly Pro Asp Trp Leu Glu Leu Ser Glu Met Thr Glu Gln Pro 
            660                 665                 670         


Asp Tyr Asp Leu Glu Thr Phe Val Asn Lys Ala Glu Ser Ala Leu Ala 
        675                 680                 685             


Gln Gln Ala Lys His Phe Ser Ala Leu Arg Asp Val Ile Lys Ala Leu 
    690                 695                 700                 


Arg Leu Ala Met Gln Leu Glu Glu Gln Ala Ser Arg Gln Ile Ser Ser 
705                 710                 715                 720 


Lys Lys Arg Pro Gln 
                725 


<210>  2135
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KIF2C__Homo_sapiens__AAH14924

<400>  2135
auggccaugg acucgucgcu ucaggcccgc cuguuucccg gucucgcuau caagauccaa       60

cgcaguaaug guuuaauuca cagugccaau guaaggacug ugaacuugga gaaauccugu      120

guuucagugg aaugggcaga aggaggugcc acaaagggca aagagauuga uuuugaugau      180

guggcugcaa uaaacccaga acucuuacag cuucuucccu uacauccgaa ggacaaucug      240

cccuugcagg aaaauguaac aauccagaaa caaaaacgga gauccgucaa cuccaaaauu      300

ccugcuccaa aagaaagucu ucgaagccgc uccacucgca uguccacugu cucagagcuu      360

cgcaucacgg cucaggagaa ugacauggag guggagcugc cugcagcugc aaacucccgc      420

aagcaguuuu caguuccucc ugcccccacu aggccuuccu gcccugcagu ggcugaaaua      480

ccauugagga uggucagcga ggagauggaa gagcaagucc auuccauccg aggcagcucu      540

ucugcaaacc cugugaacuc aguucggagg aaaucauguc uugugaagga aguggaaaaa      600

augaagaaca agcgagaaga gaagaaggcc cagaacucug aaaugagaau gaagagagcu      660

caggaguaug acaguaguuu uccaaacugg gaauuugccc gaaugauuaa agaauuucgg      720

gcuacuuugg aaugucaucc acuuacuaug acugauccua ucgaagagca cagaauaugu      780

gucuguguua ggaaacgccc acugaauaag caagaauugg ccaagaaaga aauugaugug      840

auuuccauuc cuagcaagug ucuccucuug guacaugaac ccaaguugaa aguggacuua      900

acaaaguauc uggagaacca agcauucugc uuugacuuug cauuugauga aacagcuucg      960

aaugaaguug ucuacagguu cacagcaagg ccacugguac agacaaucuu ugaaggugga     1020

aaagcaacuu guuuugcaua uggccagaca ggaaguggca agacacauac uaugggcgga     1080

gaccucucug ggaaagccca gaaugcaucc aaagggaucu augccauggc cucccgggac     1140

gucuuccucc ugaagaauca acccugcuac cggaaguugg gccuggaagu cuaugugaca     1200

uucuucgaga ucuacaaugg gaagcuguuu gaccugcuca acaagaaggc caagcugcgc     1260

gugcuggagg acggcaagca acaggugcaa gugguggggc ugcaggagca ucugguuaac     1320

ucugcugaug augucaucaa gaugaucgac augggcagcg ccugcagaac cucugggcag     1380

acauuugcca acuccaauuc cucccgcucc cacgcgugcu uccaaauuau ucuucgagcu     1440

aaagggagaa ugcauggcaa guucucuuug guagaucugg cagggaauga gcgaggcgcg     1500

gacacuucca gugcugaccg gcagacccgc auggagggcg cagaaaucaa caagagucuc     1560

uuagcccuga aggagugcau cagggcccug ggacagaaca aggcucacac cccguuccgu     1620

gagagcaagc ugacacaggu gcugagggac uccuucauug gggagaacuc uaggacuugc     1680

augauugcca cgaucucacc aggcauaagc uccugugaau auacuuuaaa cacccugaga     1740

uaugcagaca gggucaagga gcugagcccc cacagugggc ccaguggaga gcaguugauu     1800

caaauggaaa cagaagagau ggaagccugc ucuaacgggg cgcugauucc aggcaauuua     1860

uccaaggaag aggaggaacu gucuucccag auguccagcu uuaacgaagc caugacucag     1920

aucagggagc uggaggagaa ggcuauggaa gagcucaagg agaucauaca gcaaggacca     1980

gacuggcuug agcucucuga gaugaccgag cagccagacu augaccugga gaccuuugug     2040

aacaaagcgg aaucugcucu ggcccagcaa gccaagcauu ucucagcccu gcgagauguc     2100

aucaaggccu ugcgccuggc caugcagcug gaagagcagg cuagcagaca aauaagcagc     2160

aagaaacggc cccaguga                                                   2178


<210>  2136
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KIF2C__Homo_sapiens__AAH14924

<400>  2136
auggccaugg acagcucccu gcaggcccgc cucuuccccg gccuggcgau caagauccag       60

cggagcaacg ggcugaucca cuccgccaac gugcgcaccg ucaaccucga gaaguccugc      120

gugagcgugg agugggccga gggcggggcc accaagggca aggagaucga cuucgacgac      180

gucgccgcga ucaacccgga gcugcugcag cuccugcccc ugcaccccaa ggacaaccuc      240

ccccugcagg agaacgugac gauccagaag cagaagcggc gcagcgugaa cuccaagauc      300

ccggccccca aggagagccu gcggucccgc agcacccgga uguccaccgu cagcgagcuc      360

cgcaucaccg cccaggagaa cgacauggag guggagcugc ccgccgcggc caacucccgg      420

aagcaguuca gcgugccccc ggcccccacg cgccccuccu gccccgccgu cgccgagauc      480

ccgcugcgga uggugagcga ggagauggag gagcaggucc acuccauccg cgggagcucc      540

agcgcgaacc ccgugaacag cgugcggcgc aaguccugcc ucgugaagga ggucgagaag      600

augaagaaca agcgggagga gaagaaggcc cagaacagcg agaugcgcau gaagcgggcc      660

caggaguacg acuccagcuu ccccaacugg gaguucgccc gcaugaucaa ggaguuccgg      720

gccacccugg agugccaccc ccugaccaug accgacccga ucgaggagca ccgcaucugc      780

gugugcgugc ggaagcgccc ccucaacaag caggagcugg cgaagaagga gaucgacguc      840

aucuccaucc ccagcaagug ccugcuccug gugcacgagc ccaagcugaa gguggaccuc      900

acgaaguacc uggagaacca ggccuucugc uucgacuucg ccuucgacga gaccgccucc      960

aacgaggucg uguaccgcuu caccgcccgg ccgcuggugc agaccaucuu cgagggcggc     1020

aaggcgacgu gcuucgccua cgggcagacc ggcagcggga agacccacac caugggcggg     1080

gaccucuccg gcaaggccca gaacgccagc aagggcaucu acgccauggc gucccgcgac     1140

gucuuccugc ugaagaacca gcccugcuac cggaagcucg ggcuggaggu guacgucacg     1200

uucuucgaga ucuacaacgg caagcuguuc gaccuccuga acaagaaggc caagcugcgc     1260

gugcucgagg acgggaagca gcagguccag guggugggcc ugcaggagca ccuggugaac     1320

agcgccgacg acgucaucaa gaugaucgac augggcuccg ccugccggac cagcgggcag     1380

accuucgcga acuccaacag cucccgcagc cacgccugcu uccagaucau ccuccgggcc     1440

aagggccgca ugcacgggaa guucucccug guggaccugg ccggcaacga gcgcggggcc     1500

gacaccagca gcgcggaccg gcagacgcgg auggagggcg ccgagaucaa caagucccuc     1560

cuggcccuga aggagugcau ccgcgcccuc ggccagaaca aggcccacac ccccuuccgg     1620

gagagcaagc ugacccaggu gcugcgcgac uccuucaucg gggagaacag ccggaccugc     1680

augaucgcga cgaucucccc cggcaucagc uccugcgagu acacccucaa cacccugcgc     1740

uacgccgacc gggucaagga gcugagcccg cacuccgggc ccagcggcga gcagcugauc     1800

cagauggaga ccgaggagau ggaggccugc uccaacgggg cccucauccc cggcaaccug     1860

agcaaggagg aggaggagcu guccagccag auguccagcu ucaacgaggc caugacgcag     1920

auccgcgagc ucgaggagaa ggcgauggag gagcugaagg agaucaucca gcagggcccc     1980

gacuggcugg agcucuccga gaugaccgag cagccggacu acgaccugga gaccuucgug     2040

aacaaggccg agagcgcccu ggcccagcag gcgaagcacu ucagcgcccu ccgggacgug     2100

aucaaggccc ugcgccuggc caugcagcuc gaggagcagg ccucccgcca gaucagcucc     2160

aagaagcggc cccaguga                                                   2178


<210>  2137
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KIF2C__Homo_sapiens__AAH14924

<400>  2137
auggccaugg acuccucccu ccaggcccgc cucuuccccg gccucgccau caagauccag       60

cgcuccaacg gccucaucca cuccgccaac guccgcaccg ucaaccucga gaaguccugc      120

gucuccgucg agugggccga gggcggcgcc accaagggca aggagaucga cuucgacgac      180

gucgccgcca ucaaccccga gcuccuccag cuccuccccc uccaccccaa ggacaaccuc      240

ccccuccagg agaacgucac cauccagaag cagaagcgcc gcuccgucaa cuccaagauc      300

cccgccccca aggagucccu ccgcucccgc uccacccgca uguccaccgu cuccgagcuc      360

cgcaucaccg cccaggagaa cgacauggag gucgagcucc ccgccgccgc caacucccgc      420

aagcaguucu ccgucccccc cgcccccacc cgccccuccu gccccgccgu cgccgagauc      480

ccccuccgca uggucuccga ggagauggag gagcaggucc acuccauccg cggcuccucc      540

uccgccaacc ccgucaacuc cguccgccgc aaguccugcc ucgucaagga ggucgagaag      600

augaagaaca agcgcgagga gaagaaggcc cagaacuccg agaugcgcau gaagcgcgcc      660

caggaguacg acuccuccuu ccccaacugg gaguucgccc gcaugaucaa ggaguuccgc      720

gccacccucg agugccaccc ccucaccaug accgacccca ucgaggagca ccgcaucugc      780

gucugcgucc gcaagcgccc ccucaacaag caggagcucg ccaagaagga gaucgacguc      840

aucuccaucc ccuccaagug ccuccuccuc guccacgagc ccaagcucaa ggucgaccuc      900

accaaguacc ucgagaacca ggccuucugc uucgacuucg ccuucgacga gaccgccucc      960

aacgaggucg ucuaccgcuu caccgcccgc ccccucgucc agaccaucuu cgagggcggc     1020

aaggccaccu gcuucgccua cggccagacc ggcuccggca agacccacac caugggcggc     1080

gaccucuccg gcaaggccca gaacgccucc aagggcaucu acgccauggc cucccgcgac     1140

gucuuccucc ucaagaacca gcccugcuac cgcaagcucg gccucgaggu cuacgucacc     1200

uucuucgaga ucuacaacgg caagcucuuc gaccuccuca acaagaaggc caagcuccgc     1260

guccucgagg acggcaagca gcagguccag gucgucggcc uccaggagca ccucgucaac     1320

uccgccgacg acgucaucaa gaugaucgac augggcuccg ccugccgcac cuccggccag     1380

accuucgcca acuccaacuc cucccgcucc cacgccugcu uccagaucau ccuccgcgcc     1440

aagggccgca ugcacggcaa guucucccuc gucgaccucg ccggcaacga gcgcggcgcc     1500

gacaccuccu ccgccgaccg ccagacccgc auggagggcg ccgagaucaa caagucccuc     1560

cucgcccuca aggagugcau ccgcgcccuc ggccagaaca aggcccacac ccccuuccgc     1620

gaguccaagc ucacccaggu ccuccgcgac uccuucaucg gcgagaacuc ccgcaccugc     1680

augaucgcca ccaucucccc cggcaucucc uccugcgagu acacccucaa cacccuccgc     1740

uacgccgacc gcgucaagga gcucuccccc cacuccggcc ccuccggcga gcagcucauc     1800

cagauggaga ccgaggagau ggaggccugc uccaacggcg cccucauccc cggcaaccuc     1860

uccaaggagg aggaggagcu cuccucccag auguccuccu ucaacgaggc caugacccag     1920

auccgcgagc ucgaggagaa ggccauggag gagcucaagg agaucaucca gcagggcccc     1980

gacuggcucg agcucuccga gaugaccgag cagcccgacu acgaccucga gaccuucguc     2040

aacaaggccg aguccgcccu cgcccagcag gccaagcacu ucuccgcccu ccgcgacguc     2100

aucaaggccc uccgccucgc caugcagcuc gaggagcagg ccucccgcca gaucuccucc     2160

aagaagcgcc cccaguga                                                   2178


<210>  2138
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KIF2C__Homo_sapiens__AAH14924

<400>  2138
auggccaugg acagcucccu gcaggcuaga cucuuccccg gccuugcaau caagauucaa       60

aggucuaacg ggcugauaca cucagccaau gugcggaccg ucaacuugga gaaaaguugc      120

guuagcgugg aaugggcgga gggaggugcu acaaagggca aagaaaucga uuuugacgau      180

guagccgcaa uuaauccuga guuacugcag cuacucccac ugcauccgaa ggacaaccuu      240

ccccugcagg aaaaugugac uauccagaaa caaaagcgcc gauccgucaa cucuaagauu      300

ccugccccaa aagagucguu gcguucaaga agcacgagga ugaguaccgu guccgagcuc      360

cggaucacag cucaggaaaa ugauauggag guugaacugc ccgcagccgc uaacucucgc      420

aagcaguuca gcgugccucc agcccccacu agaccuuccu guccagcggu cgcagagaua      480

ccgcugagga uggugucaga ggaaauggag gaacagguac acaguauccg ggggucuagc      540

uccgccaauc ccguuaacuc agugcgccga aaaagcugcc ucgucaagga gguggagaaa      600

augaagaaua agagagagga gaaaaaggcu caaaacagug aaaugaggau gaaacgggcc      660

caggaguacg acucuuccuu uccuaauugg gaguucgcac guaugauuaa ggaguuucgc      720

gcuaccuuag aaugucaucc acugacaaug accgauccca ucgaggagca cagaauuugc      780

guguguguca ggaaacggcc ucuuaacaag caggaauugg ccaaaaagga gaucgacguu      840

auaagcauuc caucgaagug ccugcuacuc gugcaugaac ccaaacugaa gguagaucuu      900

acuaaauauc uggagaauca ggcguucugu uuugacuucg ccuuugauga aacagcaucu      960

aacgaggugg ucuaccgauu caccgcucgc ccguuggugc aaacgaucuu ugagggaggc     1020

aaggccacuu gcuucgcuua uggucagacc ggguccggaa aaacacacac uaugggcggc     1080

gaccucucag ggaaggccca gaacgcaagu aagggaauuu acgccauggc uagcagagau     1140

guuuuucugc ugaaaaauca accuuguuau aggaaguuag gucucgaagu guacgucacc     1200

uucuucgaga ucuauaacgg caaacuuuuu gaccuguuga auaagaaagc gaagcuacgg     1260

gugcuggaag acgggaagca gcagguacag guugugggac uccaagagca ccuggucaac     1320

uccgcagaug acgugaucaa aaugauugau augggcucug ccugccgcac aagcggucag     1380

accuucgcua auucaaacag uuccagaagc caugccuguu uucagauaau ccuuagggca     1440

aaggggcgua ugcacggaaa auucucucug gucgacuugg ccggcaauga gcggggcgcu     1500

gauacgucaa gugccgaccg acagacuaga auggaagggg cagagauuaa caagagccuc     1560

cuggcguuaa aagaaugcau cagggcucug ggacaaaaua aggcccauac acccuuucgc     1620

gaguccaagc uaacccaggu gcuccgggau ucuuucauag gugaaaacuc gagaacuugc     1680

augauugcaa caaucagccc aggcaucucc ucaugugagu acacccugaa uacgcuuagg     1740

uacgccgacc gcguuaaaga guugaguccu cacucugggc ccagcggaga acagcugauu     1800

cagauggaga ccgaagagau ggaggcuugc uccaacggcg cccucauccc agguaaucug     1860

ucaaaggaag aggaagaacu uagcucucaa auguccaguu uuaacgaagc aaugacacag     1920

auucgagagc uggaagagaa agcuauggag gaauugaagg agauaaucca gcaggggccc     1980

gauuggcucg aacugagcga gaugacugag caaccugacu augauuuaga aaccuucgug     2040

aauaaagccg agucugcgcu ggcccagcag gcuaagcacu uuuccgcacu acgggacgua     2100

auuaaagccc uccgucuggc uaugcaacuu gaagaacagg ccucaagaca gaucaguagc     2160

aagaagaggc cacaguga                                                   2178


<210>  2139
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KIF2C__Homo_sapiens__AAH14924

<400>  2139
auggccaugg acagcagccu gcaggccaga cuguuccccg gccuggccau caagauccag       60

agaagcaacg gccugaucca cagcgccaac gugagaaccg ugaaccugga gaagagcugc      120

gugagcgugg agugggccga gggcggcgcc accaagggca aggagaucga cuucgacgac      180

guggccgcca ucaaccccga gcugcugcag cugcugcccc ugcaccccaa ggacaaccug      240

ccccugcagg agaacgugac cauccagaag cagaagagaa gaagcgugaa cagcaagauc      300

cccgccccca aggagagccu gagaagcaga agcaccagaa ugagcaccgu gagcgagcug      360

agaaucaccg cccaggagaa cgacauggag guggagcugc ccgccgccgc caacagcaga      420

aagcaguuca gcgugccccc cgcccccacc agacccagcu gccccgccgu ggccgagauc      480

ccccugagaa uggugagcga ggagauggag gagcaggugc acagcaucag aggcagcagc      540

agcgccaacc ccgugaacag cgugagaaga aagagcugcc uggugaagga gguggagaag      600

augaagaaca agagagagga gaagaaggcc cagaacagcg agaugagaau gaagagagcc      660

caggaguacg acagcagcuu ccccaacugg gaguucgcca gaaugaucaa ggaguucaga      720

gccacccugg agugccaccc ccugaccaug accgacccca ucgaggagca cagaaucugc      780

gugugcguga gaaagagacc ccugaacaag caggagcugg ccaagaagga gaucgacgug      840

aucagcaucc ccagcaagug ccugcugcug gugcacgagc ccaagcugaa gguggaccug      900

accaaguacc uggagaacca ggccuucugc uucgacuucg ccuucgacga gaccgccagc      960

aacgaggugg uguacagauu caccgccaga ccccuggugc agaccaucuu cgagggcggc     1020

aaggccaccu gcuucgccua cggccagacc ggcagcggca agacccacac caugggcggc     1080

gaccugagcg gcaaggccca gaacgccagc aagggcaucu acgccauggc cagcagagac     1140

guguuccugc ugaagaacca gcccugcuac agaaagcugg gccuggaggu guacgugacc     1200

uucuucgaga ucuacaacgg caagcuguuc gaccugcuga acaagaaggc caagcugaga     1260

gugcuggagg acggcaagca gcaggugcag guggugggcc ugcaggagca ccuggugaac     1320

agcgccgacg acgugaucaa gaugaucgac augggcagcg ccugcagaac cagcggccag     1380

accuucgcca acagcaacag cagcagaagc cacgccugcu uccagaucau ccugagagcc     1440

aagggcagaa ugcacggcaa guucagccug guggaccugg ccggcaacga gagaggcgcc     1500

gacaccagca gcgccgacag acagaccaga auggagggcg ccgagaucaa caagagccug     1560

cuggcccuga aggagugcau cagagcccug ggccagaaca aggcccacac ccccuucaga     1620

gagagcaagc ugacccaggu gcugagagac agcuucaucg gcgagaacag cagaaccugc     1680

augaucgcca ccaucagccc cggcaucagc agcugcgagu acacccugaa cacccugaga     1740

uacgccgaca gagugaagga gcugagcccc cacagcggcc ccagcggcga gcagcugauc     1800

cagauggaga ccgaggagau ggaggccugc agcaacggcg cccugauccc cggcaaccug     1860

agcaaggagg aggaggagcu gagcagccag augagcagcu ucaacgaggc caugacccag     1920

aucagagagc uggaggagaa ggccauggag gagcugaagg agaucaucca gcagggcccc     1980

gacuggcugg agcugagcga gaugaccgag cagcccgacu acgaccugga gaccuucgug     2040

aacaaggccg agagcgcccu ggcccagcag gccaagcacu ucagcgcccu gagagacgug     2100

aucaaggccc ugagacuggc caugcagcug gaggagcagg ccagcagaca gaucagcagc     2160

aagaagagac cccaguga                                                   2178


<210>  2140
<211>  2178
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KIF2C__Homo_sapiens__AAH14924

<400>  2140
auggccaugg acagcucccu gcaggcuaga cucuuccccg gccuggccau caagauucaa       60

cggucuaacg ggcuuaucca cagcgcgaau gugcgcaccg ucaaccugga gaaauccugc      120

guuucugugg aaugggcuga gggaggcgcc acaaagggga aagaaauuga uuuugacgau      180

guggccgcua ucaauccuga gcuccugcag cuucugccgc uccaucccaa ggacaaccug      240

ccucugcagg aaaaugucac gauucagaaa caaaagagac ggagcgugaa cuccaagauc      300

cccgccccua aagagucucu ccgcagcaga uccacccgga ugagcacagu uucugagcug      360

cgcaucaccg cucaggaaaa ugauauggag guggaacuuc ccgccgcggc caacuccaga      420

aagcaguuca gcgucccucc ggcucccaca cggccuucuu gucccgccgu ggcugagauu      480

ccucugcgca ugguuuccga ggaaauggag gaacaggugc acagcaucag aggaucuucc      540

agcgccaauc ccgucaacuc cgugcggcgc aaaucuugcc ucgugaagga ggucgaaaag      600

augaagaaua agagagagga gaaaaaggcg caaaacagcg aaaugcggau gaaacgcgcc      660

caggaguacg acuccagcuu uccgaauugg gaguucgcua gaaugauuaa ggaguuucgg      720

gccacccugg aaugucaucc ucuuacaaug accgauccca ucgaggagca cagaauuugc      780

guuugugugc gcaaacggcc ucugaacaag caggaacucg cuaaaaagga gaucgacgug      840

auuucuaucc ccuccaagug ccugcugcuc guccaugaac ccaaacugaa gguggaucuu      900

acgaaauauc uggagaauca ggccuucugu uuugacuucg ccuuugauga aaccgcuagc      960

aacgagguug uguacagauu cacagcgcgc ccucucgucc aaaccaucuu ugagggcggg     1020

aaggccacau gcuucgcuua uggacagacc ggcucuggca aaacgcacac aaugggaggg     1080

gaccugagcg gcaaggccca gaacgccucc aaggggauuu acgcuauggc cucucgggau     1140

guguuucuuc ugaaaaauca accguguuau agaaagcucg gacuggaagu uuacgugacc     1200

uucuucgaga ucuauaacgg caaacuguuu gaccuccuga auaagaaagc gaaacuucgc     1260

guccuggaag acgggaagca acaggugcag gucgugggac uccaggagca ccugguuaac     1320

agcgcugaug acgugauuaa aaugaucgau augggcuccg ccugccggac aagcggccag     1380

accuucgcca auucuaacuc cagcagaucu caugcuuguu uucagauuau ccuucgcgcc     1440

aaggggcgga ugcacggaaa auucucccug gucgaccucg cuggcaauga gagaggggcc     1500

gauaccagcu ccgcggaccg ccagacacgg auggaaggag ccgagaucaa caagucucug     1560

cuggcucuca aagaaugcau uagagcccug ggccaaaaua aggcucauac gcccuuucgg     1620

gagagcaaac uuacccaggu gcugcgcgau uccuucaucg gggaaaacuc uagaacaugc     1680

augauugcca ccaucagccc uggaauuucc agcugugagu acacacucaa uacccugcgg     1740

uacgcggaca gaguuaagga gcugucuccc cacuccggcc cuagcggcga acagcuuauc     1800

cagauggaga cggaagagau ggaagccugc ucuaacgggg cucucauccc cggaaaucug     1860

uccaaggagg aggaagaacu gagcucucaa augagcuccu uuaacgaagc caugacacag     1920

auucgcgagc ucgaagagaa agcuauggag gaacugaagg agaucauuca gcagggcccg     1980

gauuggcuug aacugagcga gaugaccgag caaccugacu augaucucga aaccuucgug     2040

aauaaagccg agucugcccu ggcucagcag gcgaagcacu uuuccgcccu gcgggacguc     2100

aucaaagcuc uuagacucgc caugcaacug gaggaacagg ccagccgcca gauuuccucu     2160

aagaagagac cccaguga                                                   2178


<210>  2141
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KK-LC-1__Homo_sapiens__Q5H943

<400>  2141

Met Asn Phe Tyr Leu Leu Leu Ala Ser Ser Ile Leu Cys Ala Leu Ile 
1               5                   10                  15      


Val Phe Trp Lys Tyr Arg Arg Phe Gln Arg Asn Thr Gly Glu Met Ser 
            20                  25                  30          


Ser Asn Ser Thr Ala Leu Ala Leu Val Arg Pro Ser Ser Ser Gly Leu 
        35                  40                  45              


Ile Asn Ser Asn Thr Asp Asn Asn Leu Ala Val Tyr Asp Leu Ser Arg 
    50                  55                  60                  


Asp Ile Leu Asn Asn Phe Pro His Ser Ile Ala Arg Gln Lys Arg Ile 
65                  70                  75                  80  


Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu Glu His 
                85                  90                  95      


Thr Leu Leu Ser Lys Gly Phe Arg Gly Ala Ser Pro His Arg Lys Ser 
            100                 105                 110         


Thr 
    


<210>  2142
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KK-LC-1__Homo_sapiens__AAH62223

<400>  2142
augaacuucu auuuacuccu agcgagcagc auucugugug ccuugauugu cuucuggaaa       60

uaucgccgcu uucagagaaa cacuggcgaa augucaucaa auucaacugc ucuugcacua      120

gugagacccu cuucuucugg guuaauuaac agcaauacag acaacaaucu ugcagucuac      180

gaccucucuc gggauauuuu aaauaauuuc ccacacucaa uagccaggca gaagcgaaua      240

uugguaaacc ucaguauggu ggaaaacaag cugguugaac uggaacauac ucuacuuagc      300

aaggguuuca gaggugcauc accucaccgg aaauccaccu aa                         342


<210>  2143
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KK-LC-1__Homo_sapiens__AAH62223

<400>  2143
augaacuucu accugcuccu ggccagcucc auccugugcg cccucaucgu guucuggaag       60

uaccgccggu uccagcgcaa caccggcgag augagcucca acagcaccgc gcuggcccug      120

guccggcccu ccagcuccgg gcucaucaac agcaacacgg acaacaaccu ggccguguac      180

gaccuguccc gcgacauccu caacaacuuc ccgcacagca ucgcccggca gaagcgcauc      240

cuggugaacc uguccauggu cgagaacaag cucguggagc uggagcacac ccugcucagc      300

aagggcuucc gcggggccag cccccaccgg aaguccaccu ga                         342


<210>  2144
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KK-LC-1__Homo_sapiens__AAH62223

<400>  2144
augaacuucu accuccuccu cgccuccucc auccucugcg cccucaucgu cuucuggaag       60

uaccgccgcu uccagcgcaa caccggcgag auguccucca acuccaccgc ccucgcccuc      120

guccgccccu ccuccuccgg ccucaucaac uccaacaccg acaacaaccu cgccgucuac      180

gaccucuccc gcgacauccu caacaacuuc ccccacucca ucgcccgcca gaagcgcauc      240

cucgucaacc ucuccauggu cgagaacaag cucgucgagc ucgagcacac ccuccucucc      300

aagggcuucc gcggcgccuc cccccaccgc aaguccaccu ga                         342


<210>  2145
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KK-LC-1__Homo_sapiens__AAH62223

<400>  2145
augaacuucu accugcuccu ugccagcucc auccugugcg cuuugauugu guuuuggaag       60

uauagaaggu uccagcggaa uaccggcgag augucuucaa acaguacagc auuagcccug      120

guccgcccca gcuccucugg gcuaauaaau ucgaacacug acaauaaccu cgcgguuuac      180

gaucugucac gagacauccu uaauaacuuu ccucacagca uugcucguca aaaacggauc      240

cuggugaauu ugaguauggu agaaaacaag cucguggagc uggaacauac gcugcucucc      300

aaaggauuca ggggugccuc uccacacaga aagagcaccu ga                         342


<210>  2146
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KK-LC-1__Homo_sapiens__AAH62223

<400>  2146
augaacuucu accugcugcu ggccagcagc auccugugcg cccugaucgu guucuggaag       60

uacagaagau uccagagaaa caccggcgag augagcagca acagcaccgc ccuggcccug      120

gugagaccca gcagcagcgg ccugaucaac agcaacaccg acaacaaccu ggccguguac      180

gaccugagca gagacauccu gaacaacuuc ccccacagca ucgccagaca gaagagaauc      240

cuggugaacc ugagcauggu ggagaacaag cugguggagc uggagcacac ccugcugagc      300

aagggcuuca gaggcgccag cccccacaga aagagcaccu ga                         342


<210>  2147
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KK-LC-1__Homo_sapiens__AAH62223

<400>  2147
augaacuucu accugcuccu ggccagcucc auccuuugcg cucugauugu guuuuggaag       60

uauagacggu uccagcgcaa uaccggcgag augucuagca acuccacagc ccucgcgcug      120

gucagacccu cuagcuccgg gcuuaucaau ucuaacacgg acaauaaccu ggcuguuuac      180

gaucucagcc gggacauucu gaauaacuuu ccucacucca ucgcccgcca aaaacggauu      240

cuggugaauc ucagcauggu ggaaaacaag cuggucgagc uugaacauac ccugcucucu      300

aaaggauuca gaggcgccuc cccgcaccgc aagagcacau ga                         342


<210>  2148
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LDLR__Homo_sapiens__P01130

<400>  2148

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  2149
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LDLR__Homo_sapiens__AAA56833

<400>  2149
auggggcccu ggggcuggaa auugcgcugg accgucgccu ugcuccucgc cgcggcgggg       60

acugcagugg gcgacagaug ugaaagaaac gaguuccagu gccaagacgg gaaaugcauc      120

uccuacaagu gggucugcga uggcagcgcu gagugccagg auggcucuga ugagucccag      180

gagacgugcu ugucugucac cugcaaaucc ggggacuuca gcuguggggg ccgugucaac      240

cgcugcauuc cucaguucug gaggugcgau ggccaagugg acugcgacaa cggcucagac      300

gagcaaggcu guccccccaa gacgugcucc caggacgagu uucgcugcca cgaugggaag      360

ugcaucucuc ggcaguucgu cugugacuca gaccgggacu gcuuggacgg cucagacgag      420

gccuccugcc cggugcucac cugugguccc gccagcuucc agugcaacag cuccaccugc      480

aucccccagc ugugggccug cgacaacgac cccgacugcg aagauggcuc ggaugagugg      540

ccgcagcgcu guaggggucu uuacguguuc caaggggaca guagccccug cucggccuuc      600

gaguuccacu gccuaagugg cgagugcauc cacuccagcu ggcgcuguga ugguggcccc      660

gacugcaagg acaaaucuga cgaggaaaac ugcgcugugg ccaccugucg cccugacgaa      720

uuccagugcu cugauggaaa cugcauccau ggcagccggc agugugaccg ggaauaugac      780

ugcaaggaca ugagcgauga aguuggcugc guuaauguga cacucugcga gggacccaac      840

aaguucaagu gucacagcgg cgaaugcauc acccuggaca aagucugcaa cauggcuaga      900

gacugccggg acuggucaga ugaacccauc aaagagugcg ggaccaacga augcuuggac      960

aacaacggcg gcuguuccca cgucugcaau gaccuuaaga ucggcuacga gugccugugc     1020

cccgacggcu uccagcuggu ggcccagcga agaugcgaag auaucgauga gugucaggau     1080

cccgacaccu gcagccagcu cugcgugaac cuggagggug gcuacaagug ccagugugag     1140

gaaggcuucc agcuggaccc ccacacgaag gccugcaagg cugugggcuc caucgccuac     1200

cucuucuuca ccaaccggca cgaggucagg aagaugacgc uggaccggag cgaguacacc     1260

agccucaucc ccaaccugag gaacgugguc gcucuggaca cggagguggc cagcaauaga     1320

aucuacuggu cugaccuguc ccagagaaug aucugcagca cccagcuuga cagagcccac     1380

ggcgucucuu ccuaugacac cgucaucagc agggacaucc aggcccccga cgggcuggcu     1440

guggacugga uccacagcaa caucuacugg accgacucug uccugggcac ugucucuguu     1500

gcggauacca agggcgugaa gaggaaaacg uuauucaggg agaacggcuc caagccaagg     1560

gccaucgugg uggauccugu ucauggcuuc auguacugga cugacugggg aacucccgcc     1620

aagaucaaga aagggggccu gaauggugug gacaucuacu cgcuggugac ugaaaacauu     1680

caguggccca auggcaucac ccuagaucuc cucaguggcc gccucuacug gguugacucc     1740

aaacuucacu ccaucucaag caucgauguc aaugggggca accggaagac caucuuggag     1800

gaugaaaaga ggcuggccca ccccuucucc uuggccgucu uugaggacaa aguauuuugg     1860

acagauauca ucaacgaagc cauuuucagu gccaaccgcc ucacagguuc cgaugucaac     1920

uuguuggcug aaaaccuacu guccccagag gauauggucc ucuuccacaa ccucacccag     1980

ccaagaggag ugaacuggug ugagaggacc acccugagca auggcggcug ccaguaucug     2040

ugccucccug ccccgcagau caacccccac ucgcccaagu uuaccugcgc cugcccggac     2100

ggcaugcugc uggccaggga caugaggagc ugccucacag aggcugaggc ugcaguggcc     2160

acccaggaga cauccaccgu caggcuaaag gucagcucca cagccguaag gacacagcac     2220

acaaccaccc ggccuguucc cgacaccucc cggcugccug gggccacccc ugggcucacc     2280

acgguggaga uagugacaau gucucaccaa gcucugggcg acguugcugg cagaggaaau     2340

gagaagaagc ccaguagcgu gagggcucug uccauugucc uccccaucgu gcuccucguc     2400

uuccuuugcc ugggggucuu ccuucuaugg aagaacuggc ggcuuaagaa caucaacagc     2460

aucaacuuug acaaccccgu cuaucagaag accacagagg augaggucca cauuugccac     2520

aaccaggacg gcuacagcua ccccucgaga cagaugguca gucuggagga ugacguggcg     2580

uga                                                                   2583


<210>  2150
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LDLR__Homo_sapiens__AAA56833

<400>  2150
augggccccu ggggguggaa gcugcgcugg accguggccc uccugcuggc cgcggccggc       60

accgccgucg gggaccggug cgagcgcaac gaguuccagu gccaggacgg caagugcauc      120

agcuacaagu gggugugcga cggguccgcc gagugccagg acggcagcga cgagucccag      180

gagacgugcc ucagcgugac cugcaagucc ggcgacuuca gcugcggggg ccgggucaac      240

cgcugcaucc cgcaguucug gcggugcgac ggccaggugg acugcgacaa cggguccgac      300

gagcaggggu gcccgcccaa gaccugcagc caggacgagu uccgcugcca cgacggcaag      360

ugcaucuccc ggcaguucgu gugcgacagc gaccgcgacu gccuggacgg cuccgacgag      420

gccagcugcc ccguccugac cugcgggccc gcguccuucc agugcaacag cuccacgugc      480

aucccccagc ucugggccug cgacaacgac cccgacugcg aggacggcag cgacgagugg      540

ccccagcggu gccgcgggcu guacguguuc cagggcgacu ccagcccgug cuccgccuuc      600

gaguuccacu gccugagcgg cgagugcauc cacagcuccu ggcggugcga cgggggcccc      660

gacugcaagg acaagagcga cgaggagaac ugcgccgugg cgaccugccg ccccgacgag      720

uuccagugcu ccgacgggaa cugcauccac ggcagccggc agugcgaccg cgaguacgac      780

ugcaaggaca uguccgacga ggucgggugc gugaacguga cccucugcga gggccccaac      840

aaguucaagu gccacagcgg cgagugcauc acccuggaca aggucugcaa cauggcccgg      900

gacugccgcg acugguccga cgagccgauc aaggagugcg ggacgaacga gugccuggac      960

aacaacggcg ggugcagcca cgugugcaac gaccucaaga ucggcuacga gugccugugc     1020

cccgacgggu uccagcuggu ggcccagcgg cgcugcgagg acaucgacga gugccaggac     1080

cccgacacgu gcucccagcu cugcgucaac cuggagggcg gcuacaagug ccagugcgag     1140

gagggguucc agcuggaccc ccacaccaag gccugcaagg ccgugggcag caucgcguac     1200

cucuucuuca ccaaccggca cgaggugcgc aagaugacgc uggaccgguc cgaguacacc     1260

agccugaucc cgaaccuccg caacgucgug gcccuggaca ccgagguggc cuccaaccgc     1320

aucuacugga gcgaccuguc ccagcggaug aucugcagca cccagcucga ccgcgcccac     1380

ggggucucca gcuacgacac ggugaucucc cgggacaucc aggcccccga cggccuggcg     1440

guggacugga uccacagcaa caucuacugg accgacagcg uccuggggac cguguccguc     1500

gccgacacca agggcgugaa gcgcaagacc cucuuccggg agaacggcag caagccccgc     1560

gccaucgugg ucgaccccgu gcacggguuc auguacugga ccgacugggg caccccggcc     1620

aagaucaaga agggcgggcu gaacggcgug gacaucuacu cccuggucac cgagaacauc     1680

caguggccca acgggaucac gcucgaccug cugagcggcc ggcucuacug gguggacucc     1740

aagcugcaca gcaucuccag caucgacgug aacgggggca accgcaagac cauccuggag     1800

gacgagaagc ggcucgccca ccccuucucc cuggcggucu ucgaggacaa gguguucugg     1860

accgacauca ucaacgaggc caucuucagc gccaaccgcc ugaccggguc cgacgugaac     1920

cuccuggccg agaaccugcu cagccccgag gacauggucc uguuccacaa ccugacgcag     1980

ccgcggggcg ugaacuggug cgagcgcacc acccucucca acggcgggug ccaguaccug     2040

ugccugcccg cgccccagau caacccccac agcccgaagu ucacgugcgc cugccccgac     2100

ggcaugcucc uggcccggga caugcgcucc ugccugaccg aggccgaggc cgcgguggcc     2160

acccaggaga ccagcaccgu ccggcugaag guguccagca cggccgugcg cacccagcac     2220

accaccaccc ggcccguccc ggacacgagc cgccuccccg gggccacccc cggccugacc     2280

accguggaga ucgugacgau gucccaccag gcccuggggg acgucgcggg ccggggcaac     2340

gagaagaagc ccagcuccgu gcgcgcccuc agcaucgugc ugccgaucgu ccugcucgug     2400

uuccugugcc uggggguguu ccuccugugg aagaacuggc gccugaagaa caucaacucc     2460

aucaacuucg acaaccccgu cuaccagaag accaccgagg acgaggugca caucugccac     2520

aaccaggacg gcuacagcua ccccucccgg cagaugguga gccucgagga cgacgucgcc     2580

uga                                                                   2583


<210>  2151
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LDLR__Homo_sapiens__AAA56833

<400>  2151
augggccccu ggggcuggaa gcuccgcugg accgucgccc uccuccucgc cgccgccggc       60

accgccgucg gcgaccgcug cgagcgcaac gaguuccagu gccaggacgg caagugcauc      120

uccuacaagu gggucugcga cggcuccgcc gagugccagg acggcuccga cgagucccag      180

gagaccugcc ucuccgucac cugcaagucc ggcgacuucu ccugcggcgg ccgcgucaac      240

cgcugcaucc cccaguucug gcgcugcgac ggccaggucg acugcgacaa cggcuccgac      300

gagcagggcu gcccccccaa gaccugcucc caggacgagu uccgcugcca cgacggcaag      360

ugcaucuccc gccaguucgu cugcgacucc gaccgcgacu gccucgacgg cuccgacgag      420

gccuccugcc ccguccucac cugcggcccc gccuccuucc agugcaacuc cuccaccugc      480

aucccccagc ucugggccug cgacaacgac cccgacugcg aggacggcuc cgacgagugg      540

ccccagcgcu gccgcggccu cuacgucuuc cagggcgacu ccucccccug cuccgccuuc      600

gaguuccacu gccucuccgg cgagugcauc cacuccuccu ggcgcugcga cggcggcccc      660

gacugcaagg acaaguccga cgaggagaac ugcgccgucg ccaccugccg ccccgacgag      720

uuccagugcu ccgacggcaa cugcauccac ggcucccgcc agugcgaccg cgaguacgac      780

ugcaaggaca uguccgacga ggucggcugc gucaacguca cccucugcga gggccccaac      840

aaguucaagu gccacuccgg cgagugcauc acccucgaca aggucugcaa cauggcccgc      900

gacugccgcg acugguccga cgagcccauc aaggagugcg gcaccaacga gugccucgac      960

aacaacggcg gcugcuccca cgucugcaac gaccucaaga ucggcuacga gugccucugc     1020

cccgacggcu uccagcucgu cgcccagcgc cgcugcgagg acaucgacga gugccaggac     1080

cccgacaccu gcucccagcu cugcgucaac cucgagggcg gcuacaagug ccagugcgag     1140

gagggcuucc agcucgaccc ccacaccaag gccugcaagg ccgucggcuc caucgccuac     1200

cucuucuuca ccaaccgcca cgagguccgc aagaugaccc ucgaccgcuc cgaguacacc     1260

ucccucaucc ccaaccuccg caacgucguc gcccucgaca ccgaggucgc cuccaaccgc     1320

aucuacuggu ccgaccucuc ccagcgcaug aucugcucca cccagcucga ccgcgcccac     1380

ggcgucuccu ccuacgacac cgucaucucc cgcgacaucc aggcccccga cggccucgcc     1440

gucgacugga uccacuccaa caucuacugg accgacuccg uccucggcac cgucuccguc     1500

gccgacacca agggcgucaa gcgcaagacc cucuuccgcg agaacggcuc caagccccgc     1560

gccaucgucg ucgaccccgu ccacggcuuc auguacugga ccgacugggg cacccccgcc     1620

aagaucaaga agggcggccu caacggcguc gacaucuacu cccucgucac cgagaacauc     1680

caguggccca acggcaucac ccucgaccuc cucuccggcc gccucuacug ggucgacucc     1740

aagcuccacu ccaucuccuc caucgacguc aacggcggca accgcaagac cauccucgag     1800

gacgagaagc gccucgccca ccccuucucc cucgccgucu ucgaggacaa ggucuucugg     1860

accgacauca ucaacgaggc caucuucucc gccaaccgcc ucaccggcuc cgacgucaac     1920

cuccucgccg agaaccuccu cucccccgag gacauggucc ucuuccacaa ccucacccag     1980

ccccgcggcg ucaacuggug cgagcgcacc acccucucca acggcggcug ccaguaccuc     2040

ugccuccccg ccccccagau caacccccac ucccccaagu ucaccugcgc cugccccgac     2100

ggcaugcucc ucgcccgcga caugcgcucc ugccucaccg aggccgaggc cgccgucgcc     2160

acccaggaga ccuccaccgu ccgccucaag gucuccucca ccgccguccg cacccagcac     2220

accaccaccc gccccguccc cgacaccucc cgccuccccg gcgccacccc cggccucacc     2280

accgucgaga ucgucaccau gucccaccag gcccucggcg acgucgccgg ccgcggcaac     2340

gagaagaagc ccuccuccgu ccgcgcccuc uccaucgucc uccccaucgu ccuccucguc     2400

uuccucugcc ucggcgucuu ccuccucugg aagaacuggc gccucaagaa caucaacucc     2460

aucaacuucg acaaccccgu cuaccagaag accaccgagg acgaggucca caucugccac     2520

aaccaggacg gcuacuccua ccccucccgc cagauggucu cccucgagga cgacgucgcc     2580

uga                                                                   2583


<210>  2152
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LDLR__Homo_sapiens__AAA56833

<400>  2152
augggccccu ggggguggaa gcugagaugg accguggccc uccuucuggc ugcagccgga       60

acagcggucg gugacaggug cgagcggaac gaauuucagu gucaagaugg caaaugcauc      120

agcuacaagu ggguuuguga cggguccgcu gagugccagg auggaucuga cgaaucacag      180

gagacuuguu ugagugugac gugcaaaagc ggcgauuuuu ccuguggugg gcgcguaaau      240

cgaugcauuc cucaguucug gcguugugac ggacaagugg auugcgacaa cggcucugau      300

gaacagggcu guccaccgaa gaccugcucg caggacgagu uuagaugcca cgaugggaaa      360

uguauaucaa ggcaguucgu cugcgacagc gaucgggacu guuuagacgg aagugaugag      420

gccuccugcc ccgugcugac augugguccu gcaucuuuuc aaugcaauag cuccacuugu      480

aucccacagc uaugggccug cgacaacgau cccgacugug aagauggcuc agacgagugg      540

ccucagcgcu gcagagggcu cuauguuuuc cagggagaua guagcccaug uucugcuuuu      600

gaguuccauu gccuguccgg cgaaugcauu cacucaagcu ggagguguga cggugggccc      660

gauugcaagg acaagaguga ugaggaaaau ugugcagugg cuaccugccg gccugacgag      720

uuucaauguu cugacggaaa cugcauccau ggcucccgcc agugugaucg agaauacgac      780

ugcaaagaua ugagcgacga ggucggcugu gugaauguaa cacuuugcga agggccaaac      840

aaguucaaau gucacucggg agagugcauu acccuggaua agguuugcaa uauggccaga      900

gacuguaggg auuggucuga cgagccgauc aaagaaugcg guacuaacga guguuuggau      960

aauaacggcg ggugcuccca uguguguaau gaccucaaga uaggauauga augccugugu     1020

cccgauggcu uucagcuggu cgcccaacgg cguugcgagg acaucgauga augucaggac     1080

ccugacacau gcucacagcu cugugugaac uuagagggug gguacaagug ccagugcgag     1140

gaaggcuucc aacuggaucc acacaccaaa gcguguaagg cagugggaag uauugccuau     1200

cuuuucuuca cgaaucgcca cgaggucaga aaaaugacuu uggacaggag cgaauacacc     1260

ucccugaucc ccaaccuacg gaacguugug gcucucgaua cagagguagc cucuaaucga     1320

auuuauugga gcgaccuguc acagcgcaug aucugcagua cucagcuuga uagagcacau     1380

ggcgugucca gcuacgacac cgucauaucu agggauauuc aggcuccuga cgggcuggcc     1440

guggauugga uccacucaaa cauuuacugg acagacagug uuuugggaac cgugagcguc     1500

gcggauacga agggugugaa acggaagacu cucuuccgcg aaaauggcuc caaaccaaga     1560

gccaucguag uugaccccgu gcauggguuu auguauugga cagauugggg aaccccggca     1620

aagaucaaga aaggcggucu gaacgggguc gacauuuacu cuuuagugac ugagaauaua     1680

caauggccua acggcaucac acuggaccuc cuuucgggaa ggcuguauug ggucgauagc     1740

aaguugcacu ccauuucaag uaucgacgug aauggcggga accguaaaac cauacuagag     1800

gaugaaaagc ggcuggcuca ccccuucucu cucgccguuu uugaggacaa aguguucugg     1860

acggauauua ucaaugaagc uaucuuuagc gccaaccgac ugaccggauc cgacguaaau     1920

cuucuggcag agaacuugcu cucaccagag gauauggucc uguuccauaa uuuaacacag     1980

ccuagaggug ugaacuggug ugaaaggacu acccugagca auggcgggug ccaguaccua     2040

ugucuccccg ccccacagau uaacccccac ucuccuaagu uuacaugcgc uuguccagac     2100

ggaaugcugc uugcgcgcga uaugcggucc ugcuugacug aggcagaagc cgcuguugcc     2160

acccaagaga caaguaccgu gagacugaag gucagcucua cugcagugag gacgcagcau     2220

acaaccacuc gcccgguacc cgacaccucc cgacucccug gcgccacacc aggucugacc     2280

acuguggaaa ucguuacaau gucacaccag gcucuugggg augucgccgg ccggggaaac     2340

gagaaaaagc ccaguagcgu gcgugcacug ucgauugugu ugccuauagu ccuccugguu     2400

uucuuauguc ugggcguguu ucuacucugg aaaaauugga gacugaagaa caucaauucc     2460

auuaacuucg acaauccagu guaucagaaa acgaccgagg acgaaguaca uaucugccac     2520

aaccaagaug gguacucuua ucccagcagg cagauggucu cacuugagga cgauguggcg     2580

uga                                                                   2583


<210>  2153
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LDLR__Homo_sapiens__AAA56833

<400>  2153
augggccccu ggggcuggaa gcugagaugg accguggccc ugcugcuggc cgccgccggc       60

accgccgugg gcgacagaug cgagagaaac gaguuccagu gccaggacgg caagugcauc      120

agcuacaagu gggugugcga cggcagcgcc gagugccagg acggcagcga cgagagccag      180

gagaccugcc ugagcgugac cugcaagagc ggcgacuuca gcugcggcgg cagagugaac      240

agaugcaucc cccaguucug gagaugcgac ggccaggugg acugcgacaa cggcagcgac      300

gagcagggcu gcccccccaa gaccugcagc caggacgagu ucagaugcca cgacggcaag      360

ugcaucagca gacaguucgu gugcgacagc gacagagacu gccuggacgg cagcgacgag      420

gccagcugcc ccgugcugac cugcggcccc gccagcuucc agugcaacag cagcaccugc      480

aucccccagc ugugggccug cgacaacgac cccgacugcg aggacggcag cgacgagugg      540

ccccagagau gcagaggccu guacguguuc cagggcgaca gcagccccug cagcgccuuc      600

gaguuccacu gccugagcgg cgagugcauc cacagcagcu ggagaugcga cggcggcccc      660

gacugcaagg acaagagcga cgaggagaac ugcgccgugg ccaccugcag acccgacgag      720

uuccagugca gcgacggcaa cugcauccac ggcagcagac agugcgacag agaguacgac      780

ugcaaggaca ugagcgacga ggugggcugc gugaacguga cccugugcga gggccccaac      840

aaguucaagu gccacagcgg cgagugcauc acccuggaca aggugugcaa cauggccaga      900

gacugcagag acuggagcga cgagcccauc aaggagugcg gcaccaacga gugccuggac      960

aacaacggcg gcugcagcca cgugugcaac gaccugaaga ucggcuacga gugccugugc     1020

cccgacggcu uccagcuggu ggcccagaga agaugcgagg acaucgacga gugccaggac     1080

cccgacaccu gcagccagcu gugcgugaac cuggagggcg gcuacaagug ccagugcgag     1140

gagggcuucc agcuggaccc ccacaccaag gccugcaagg ccgugggcag caucgccuac     1200

cuguucuuca ccaacagaca cgaggugaga aagaugaccc uggacagaag cgaguacacc     1260

agccugaucc ccaaccugag aaacguggug gcccuggaca ccgagguggc cagcaacaga     1320

aucuacugga gcgaccugag ccagagaaug aucugcagca cccagcugga cagagcccac     1380

ggcgugagca gcuacgacac cgugaucagc agagacaucc aggcccccga cggccuggcc     1440

guggacugga uccacagcaa caucuacugg accgacagcg ugcugggcac cgugagcgug     1500

gccgacacca agggcgugaa gagaaagacc cuguucagag agaacggcag caagcccaga     1560

gccaucgugg uggaccccgu gcacggcuuc auguacugga ccgacugggg cacccccgcc     1620

aagaucaaga agggcggccu gaacggcgug gacaucuaca gccuggugac cgagaacauc     1680

caguggccca acggcaucac ccuggaccug cugagcggca gacuguacug gguggacagc     1740

aagcugcaca gcaucagcag caucgacgug aacggcggca acagaaagac cauccuggag     1800

gacgagaaga gacuggccca ccccuucagc cuggccgugu ucgaggacaa gguguucugg     1860

accgacauca ucaacgaggc caucuucagc gccaacagac ugaccggcag cgacgugaac     1920

cugcuggccg agaaccugcu gagccccgag gacauggugc uguuccacaa ccugacccag     1980

cccagaggcg ugaacuggug cgagagaacc acccugagca acggcggcug ccaguaccug     2040

ugccugcccg ccccccagau caacccccac agccccaagu ucaccugcgc cugccccgac     2100

ggcaugcugc uggccagaga caugagaagc ugccugaccg aggccgaggc cgccguggcc     2160

acccaggaga ccagcaccgu gagacugaag gugagcagca ccgccgugag aacccagcac     2220

accaccacca gacccgugcc cgacaccagc agacugcccg gcgccacccc cggccugacc     2280

accguggaga ucgugaccau gagccaccag gcccugggcg acguggccgg cagaggcaac     2340

gagaagaagc ccagcagcgu gagagcccug agcaucgugc ugcccaucgu gcugcuggug     2400

uuccugugcc ugggcguguu ccugcugugg aagaacugga gacugaagaa caucaacagc     2460

aucaacuucg acaaccccgu guaccagaag accaccgagg acgaggugca caucugccac     2520

aaccaggacg gcuacagcua ccccagcaga cagaugguga gccuggagga cgacguggcc     2580

uga                                                                   2583


<210>  2154
<211>  2583
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LDLR__Homo_sapiens__AAA56833

<400>  2154
augggccccu ggggguggaa gcugagaugg accguggccc uccugcuugc ugccgcggga       60

acagcugucg gcgaccggug cgagcgcaac gaguuccagu gucaagaugg gaaaugcauc      120

agcuacaagu ggguuuguga cggauccgcc gaaugccagg auggcucuga cgaaagccag      180

gagacguguc uguccgugac cugcaaaucu ggggauuuua gcuguggagg cagagugaau      240

cggugcauuc cucaguucug gcgcugugac ggccaagucg auugcgacaa cggguccgau      300

gaacagggau guccgcccaa gacaugcucu caggacgagu uuagaugcca cgauggcaaa      360

uguaucagcc ggcaguucgu gugcgacucc gaucgcgacu gucucgacgg gagcgaugag      420

gccucuugcc cuguucugac cuguggaccc gcuuccuuuc aaugcaauag cucuacaugu      480

auuccucagc uuugggccug cgacaacgau cccgacugug aagauggcuc cgacgagugg      540

ccucagagau gccgggggcu guauguguuc cagggagaua gcucuccgug uuccgcuuuu      600

gaguuccauu gccucagcgg cgaaugcauc cacuccucuu ggcgcuguga cggcgggccc      660

gauugcaagg acaagagcga ugaggaaaau ugugccgucg cgaccugcag accugacgag      720

uuucaauguu ccgacggaaa cugcauucau ggcagccggc agugugaucg cgaauacgac      780

ugcaaagaua ugucugacga gguggggugu guuaauguga cacugugcga aggacccaac      840

aaguucaaau gucacuccgg cgagugcauc acccuggaua aggucugcaa uauggccaga      900

gacugucggg auuggagcga cgagccuauc aaagaaugcg ggacgaacga gugucucgau      960

aauaacggag gcugcucuca uguguguaau gaccugaaga uuggcuauga augccuuugu     1020

cccgaugggu uucagcuggu ggcucaacgc agaugcgagg acaucgauga augucaggac     1080

ccggauaccu gcagccagcu cugugucaac cuggagggag gcuacaagug ccagugcgag     1140

gaaggguucc aacuugaccc ucacacaaaa gccuguaagg cuguuggauc cauugccuau     1200

cuguuuuuca ccaaucggca cgaggugaga aaaaugacac ucgaccgcuc ugaauacacc     1260

agccugaucc ccaaccugcg gaacgugguc gcgcucgaua cggagguggc cuccaauaga     1320

auuuauugga gcgaccuguc ucagcgcaug aucugcucca cacagcuuga ucgggcucau     1380

ggcguuagcu cuuacgacac cgugauuucc agagauaucc aggccccuga cgggcuggcu     1440

gucgauugga uccacagcaa cauuuacugg acagacuccg ugcucggcac cguuucugug     1500

gccgauacca agggagucaa acgcaagaca cuguuccggg aaaauggcag caaacccaga     1560

gccaucgugg ucgaccccgu gcauggguuu auguauugga cggauugggg aaccccugcu     1620

aagauuaaga aaggcgggcu uaacggaguu gacaucuacu cccuggugac agagaauauu     1680

caauggccga acggcaucac ccucgaccug cugucugggc gccucuauug ggucgauagc     1740

aagcugcacu ccaucagcuc uauugacgug aauggcggaa accggaaaac aauccuugag     1800

gaugaaaaga gacuggcgca ccccuucucc cucgccguuu uugaggacaa aguguucugg     1860

accgauauua ucaaugaagc uauuuuuagc gccaaccgcc ugacgggcuc ugacgucaau     1920

cuucuggccg agaaccuccu guccccugag gauauggugc uguuccauaa ucucacacag     1980

cccagagggg ugaacuggug ugaacggacc acccugagca auggaggcug ccaguaccuu     2040

ugucugccug cuccccagau caacccgcac ucuccuaagu uuacaugcgc cugucccgac     2100

gggaugcucc uggcgcggga uaugcgcagc ugccugaccg aggcugaagc cgccguugcu     2160

acacaagaga cguccaccgu cagacuuaag gugagcucua cagccgugcg gacccagcau     2220

acaaccacga gaccuguccc cgacaccucc cgccucccug gagcuacacc cggccugacc     2280

acaguggaaa ucguuaccau gagccaccag gcccuggggg auguggcggg ccggggaaac     2340

gagaaaaagc cguccucugu cagagcccuc agcauugugc ugccuaucgu ucuucuggug     2400

uuccucuguc ugggcgucuu ucugcuuugg aaaaauuggc gccucaagaa cauuaauucc     2460

aucaacuucg acaaucccgu guaucagaaa acgacagagg acgaaguuca uauuugccac     2520

aaccaagaug gguacucuua ucccagcaga cagauggugu cccuggagga cgaugucgcu     2580

uga                                                                   2583


<210>  2155
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LGMN__Homo_sapiens__Q99538

<400>  2155

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  2156
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LGMN__Homo_sapiens__CAA70989

<400>  2156
augguuugga aaguagcugu auuccucagu guggcccugg gcauuggugc cguuccuaua       60

gaugauccug aagauggagg caagcacugg guggugaucg uggcagguuc aaauggcugg      120

uauaauuaua ggcaccaggc agacgcgugc caugccuacc agaucauuca ccgcaauggg      180

auuccugacg aacagaucgu ugugaugaug uacgaugaca uugcuuacuc ugaagacaau      240

cccacuccag gaauugugau caacaggccc aauggcacag augucuauca gggagucccg      300

aaggacuaca cuggagagga uguuacccca caaaauuucc uugcuguguu gagaggcgau      360

gcagaagcag ugaagggcau aggauccggc aaaguccuga agaguggccc ccaggaucac      420

guguucauuu acuucacuga ccauggaucu acuggaauac ugguuuuucc caaugaagau      480

cuucauguaa aggaccugaa ugagaccauc cauuacaugu acaaacacaa aauguaccga      540

aagauggugu ucuacauuga agccugugag ucugggucca ugaugaacca ccugccggau      600

aacaucaaug uuuaugcaac uacugcugcc aaccccagag agucguccua cgccuguuac      660

uaugaugaga agagguccac guaccugggg gacugguaca gcgucaacug gauggaagac      720

ucggacgugg aagaucugac uaaagagacc cugcacaagc aguaccaccu gguaaaaucg      780

cacaccaaca ccagccacgu caugcaguau ggaaacaaaa caaucuccac caugaaagug      840

augcaguuuc aggguaugaa acgcaaagcc aguucucccg ucccccuacc uccagucaca      900

caccuugacc ucacccccag cccugaugug ccucucacca ucaugaaaag gaaacugaug      960

aacaccaaug aucuggagga guccaggcag cucacggagg agauccagcg gcaucuggau     1020

gccaggcacc ucauugagaa gucagugcgu aagaucgucu ccuugcuggc agcguccgag     1080

gcugaggugg agcagcuccu guccgagaga gccccgcuca cggggcacag cugcuaccca     1140

gaggcccugc ugcacuuccg gacccacugc uucaacuggc acucccccac guacgaguau     1200

gcguugagac auuuguacgu gcuggucaac cuuugugaga agccguaucc acuucacagg     1260

auaaaauugu ccauggacca cgugugccuu ggucacuacu ga                        1302


<210>  2157
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LGMN__Homo_sapiens__CAA70989

<400>  2157
auggugugga aggucgccgu guuccugagc guggcccucg gcaucggggc gguccccauc       60

gacgacccgg aggacggcgg gaagcacugg guggugaucg ucgccggcuc caacgggugg      120

uacaacuacc gccaccaggc cgacgccugc cacgccuacc agaucaucca ccggaacggc      180

auccccgacg agcagaucgu ggugaugaug uacgacgaca ucgcguacag cgaggacaac      240

cccacccccg gcaucgucau caaccgcccg aacgggaccg acguguacca gggcgugccc      300

aaggacuaca cgggggagga cgucacgccc cagaacuucc uggccgugcu gcggggcgac      360

gccgaggccg ugaaggggau cggcuccggc aagguccuca agagcgggcc ccaggaccac      420

guguucaucu acuucaccga ccacggcucc accgggaucc ugguguuccc gaacgaggac      480

cugcacguca aggaccucaa cgagaccauc cacuacaugu acaagcacaa gauguaccgc      540

aagauggugu ucuacaucga ggcgugcgag agcggcucca ugaugaacca ccuccccgac      600

aacaucaacg uguacgccac caccgccgcc aacccccggg agagcuccua cgccugcuac      660

uacgacgaga agcgcagcac cuaccugggc gacugguacu ccgucaacug gauggaggac      720

agcgacgugg aggaccugac gaaggagacc cugcacaagc aguaccaccu ggugaagucc      780

cacaccaaca ccagccacgu caugcaguac gggaacaaga cgaucuccac caugaaggug      840

augcaguucc agggcaugaa gcggaaggcg agcucccccg ucccgcuccc gcccgugacc      900

caccuggacc ugacccccag ccccgacgug ccccucacga ucaugaagcg caagcugaug      960

aacaccaacg accuggagga gucccggcag cucaccgagg agauccagcg ccaccuggac     1020

gcccggcacc ugaucgagaa guccguccgc aagaucguga gccuccuggc cgccagcgag     1080

gccgaggugg agcagcugcu cagcgagcgg gcgccccuga ccgggcacuc cugcuacccc     1140

gaggcccugc uccacuuccg cacgcacugc uucaacuggc acagcccgac cuacgaguac     1200

gcccugcggc accuguacgu ccucgugaac cugugcgaga agcccuaccc ccugcaccgc     1260

aucaagcucu ccauggacca cgugugccug ggccacuacu ga                        1302


<210>  2158
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LGMN__Homo_sapiens__CAA70989

<400>  2158
auggucugga aggucgccgu cuuccucucc gucgcccucg gcaucggcgc cguccccauc       60

gacgaccccg aggacggcgg caagcacugg gucgucaucg ucgccggcuc caacggcugg      120

uacaacuacc gccaccaggc cgacgccugc cacgccuacc agaucaucca ccgcaacggc      180

auccccgacg agcagaucgu cgucaugaug uacgacgaca ucgccuacuc cgaggacaac      240

cccacccccg gcaucgucau caaccgcccc aacggcaccg acgucuacca gggcgucccc      300

aaggacuaca ccggcgagga cgucaccccc cagaacuucc ucgccguccu ccgcggcgac      360

gccgaggccg ucaagggcau cggcuccggc aagguccuca aguccggccc ccaggaccac      420

gucuucaucu acuucaccga ccacggcucc accggcaucc ucgucuuccc caacgaggac      480

cuccacguca aggaccucaa cgagaccauc cacuacaugu acaagcacaa gauguaccgc      540

aagauggucu ucuacaucga ggccugcgag uccggcucca ugaugaacca ccuccccgac      600

aacaucaacg ucuacgccac caccgccgcc aacccccgcg aguccuccua cgccugcuac      660

uacgacgaga agcgcuccac cuaccucggc gacugguacu ccgucaacug gauggaggac      720

uccgacgucg aggaccucac caaggagacc cuccacaagc aguaccaccu cgucaagucc      780

cacaccaaca ccucccacgu caugcaguac ggcaacaaga ccaucuccac caugaagguc      840

augcaguucc agggcaugaa gcgcaaggcc uccucccccg ucccccuccc ccccgucacc      900

caccucgacc ucacccccuc ccccgacguc ccccucacca ucaugaagcg caagcucaug      960

aacaccaacg accucgagga gucccgccag cucaccgagg agauccagcg ccaccucgac     1020

gcccgccacc ucaucgagaa guccguccgc aagaucgucu cccuccucgc cgccuccgag     1080

gccgaggucg agcagcuccu cuccgagcgc gccccccuca ccggccacuc cugcuacccc     1140

gaggcccucc uccacuuccg cacccacugc uucaacuggc acucccccac cuacgaguac     1200

gcccuccgcc accucuacgu ccucgucaac cucugcgaga agcccuaccc ccuccaccgc     1260

aucaagcucu ccauggacca cgucugccuc ggccacuacu ga                        1302


<210>  2159
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LGMN__Homo_sapiens__CAA70989

<400>  2159
auggugugga aggucgccgu uuuccugagc guggcucucg gcaucggggc aguacccauu       60

gacgauccug aggacggagg uaaacacugg guggucauag uggccggcuc caacgggugg      120

uacaauuaua gacaucaggc ggaugcuugc cacgccuacc aaaucauuca uaggaacgga      180

aucccagacg aacagauugu ugugaugaug uaugaugaca ucgcauacuc ugaggauaau      240

ccgacccccg gcauagucau caaccggccu aaugguacag acguguauca ggggguacca      300

aaggauuaca cuggagaaga cguuacgccc cagaacuuuc uugccgugcu gcgcggcgau      360

gcugaggcag ucaaaggcau ugggucagga aagguguuga aaaguggucc ucaagaccac      420

guguucaucu auuuuaccga ucauggcagc acagggauuu uagucuuccc aaaugaagac      480

cugcacguua aggaccuaaa cgagacuauc cacuacaugu acaagcauaa aauguaucga      540

aagauggugu uuuacauaga ggccugugaa uccggaucua ugaugaauca ccuccccgau      600

aacauuaaug uauaugcuac cacagccgcg aacccucgug agucgucaua cgcaugcuau      660

uacgacgaga aaagaagcac cuaucugggc gauugguaca gugugaauug gauggaagac      720

uccgaugucg aggaccuuac uaaggaaaca cugcauaaac aguaccacuu ggugaagucu      780

cacaccaaca cgagccaugu uaugcaguau gguaauaaga cuaucuccac caugaaagug      840

augcaguucc aagggaugaa gaggaaagcc ucaaguccag ucccgcugcc cccugugaca      900

caccucgauc ugacuccaag ccccgacgua ccucucacca uuaugaagcg gaaauuaaug      960

aacacaaacg aucuggagga aucucgccag cuuaccgagg aaauccagag acauuuggac     1020

gcuaggcacc ugaucgagaa guccguucgg aaaauugugu cacuacucgc cgcaagcgag     1080

gcugaagucg agcagcugcu uagugaacgc gccccacuga cgggacauuc uuguuacccc     1140

gaggcguugc uccacuuucg aacucacugc uucaauuggc auuccccgac auaugaauac     1200

gcccugagac acuuauaugu gcuggucaac cucugugaga agccuuaccc ccuucauagg     1260

auaaagcuga gcauggauca cgugugcuug ggccacuauu ga                        1302


<210>  2160
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LGMN__Homo_sapiens__CAA70989

<400>  2160
auggugugga agguggccgu guuccugagc guggcccugg gcaucggcgc cgugcccauc       60

gacgaccccg aggacggcgg caagcacugg guggugaucg uggccggcag caacggcugg      120

uacaacuaca gacaccaggc cgacgccugc cacgccuacc agaucaucca cagaaacggc      180

auccccgacg agcagaucgu ggugaugaug uacgacgaca ucgccuacag cgaggacaac      240

cccacccccg gcaucgugau caacagaccc aacggcaccg acguguacca gggcgugccc      300

aaggacuaca ccggcgagga cgugaccccc cagaacuucc uggccgugcu gagaggcgac      360

gccgaggccg ugaagggcau cggcagcggc aaggugcuga agagcggccc ccaggaccac      420

guguucaucu acuucaccga ccacggcagc accggcaucc ugguguuccc caacgaggac      480

cugcacguga aggaccugaa cgagaccauc cacuacaugu acaagcacaa gauguacaga      540

aagauggugu ucuacaucga ggccugcgag agcggcagca ugaugaacca ccugcccgac      600

aacaucaacg uguacgccac caccgccgcc aaccccagag agagcagcua cgccugcuac      660

uacgacgaga agagaagcac cuaccugggc gacugguaca gcgugaacug gauggaggac      720

agcgacgugg aggaccugac caaggagacc cugcacaagc aguaccaccu ggugaagagc      780

cacaccaaca ccagccacgu gaugcaguac ggcaacaaga ccaucagcac caugaaggug      840

augcaguucc agggcaugaa gagaaaggcc agcagccccg ugccccugcc ccccgugacc      900

caccuggacc ugacccccag ccccgacgug ccccugacca ucaugaagag aaagcugaug      960

aacaccaacg accuggagga gagcagacag cugaccgagg agauccagag acaccuggac     1020

gccagacacc ugaucgagaa gagcgugaga aagaucguga gccugcuggc cgccagcgag     1080

gccgaggugg agcagcugcu gagcgagaga gccccccuga ccggccacag cugcuacccc     1140

gaggcccugc ugcacuucag aacccacugc uucaacuggc acagccccac cuacgaguac     1200

gcccugagac accuguacgu gcuggugaac cugugcgaga agcccuaccc ccugcacaga     1260

aucaagcuga gcauggacca cgugugccug ggccacuacu ga                        1302


<210>  2161
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LGMN__Homo_sapiens__CAA70989

<400>  2161
auggugugga aggucgccgu uuuccugagc guggcucucg gcaucggggc cgugcccauu       60

gacgauccug aggacggagg caaacacugg gucgugaucg uugcgggguc caacggaugg      120

uacaauuaua gacaucaggc ugaugccugc cacgccuacc aaauuaucca ucggaacggc      180

auuccggacg aacagaucgu ggucaugaug uaugaugaca ucgcuuacuc ugaggauaau      240

cccaccccug ggauugugau caaccgcccc aauggaacag acguuuauca gggcgugccu      300

aaggauuaca cgggcgaaga cgucacaccc cagaacuuuc uggccgugcu uagaggggau      360

gcugaggccg ugaaaggaau uggcagcggg aagguccuga aauccggacc ucaagaccac      420

guuuucaucu auuuuaccga ucauggcucu accgggauuc ucguguuccc gaaugaagac      480

cugcacguga aggaccuuaa cgagacaauc cacuacaugu acaagcauaa aauguaucgg      540

aagauggucu uuuacauuga ggcgugugaa agcggaucca ugaugaauca ucugcccgau      600

aacaucaaug uguaugccac cacagcugcc aacccucgcg agucuagcua cgcuugcuau      660

uacgacgaga aaagauccac cuaucucggc gauugguaca gcguuaauug gauggaggac      720

ucugaugugg aggaccugac gaaggaaacc cugcacaaac aguaccaccu cgucaagucc      780

cacacaaaca ccagccaugu gaugcaguau ggcaauaaga caaucucuac caugaaaguu      840

augcaguucc aagggaugaa gcggaaagcc uccagccccg ugccucugcc cccggucacg      900

caccuugauc ugacaccuuc ucccgacgug ccucucacca uuaugaagcg caaacugaug      960

aacacaaacg aucuugagga auccagacag cugaccgagg aaauccagcg gcaucucgac     1020

gcgcgccacc ugauugaaaa gagcgucaga aaaaucgugu cccugcucgc cgcuucugag     1080

gccgaaguug agcagcugcu uagcgaacgg gcuccccuga ccggacauuc cuguuacccc     1140

gaggcccucc ugcacuuucg cacacacugc uucaauuggc auagcccuac guaugaauac     1200

gcccuuagac accuguaugu gcucgucaac cugugugaga agccguaccc ccugcaucgg     1260

auuaagcucu cuauggauca cgugugccug ggccacuauu ga                        1302


<210>  2162
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LIRB2__Homo_sapiens__Q8N423

<400>  2162

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210>  2163
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LIRB2__Homo_sapiens__AAL36991

<400>  2163
augaccccca ucgucacagu ccugaucugu cucgggcuga gucugggccc caggacccac       60

gugcagacag ggaccauucc caagcccacc cugugggcug agccagacuc ugugaucacc      120

caggggaguc ccgucacccu caguugucag gggagccuug aagcccagga guaccgucua      180

uauagggaga aaaaaucagc aucuuggauu acacggauac gaccagagcu ugugaagaac      240

ggccaguucc acaucccauc caucaccugg gaacacacag ggcgauaugg cugucaguau      300

uacagccgcg cucggugguc ugagcucagu gacccccugg ugcuggugau gacaggagcc      360

uacccaaaac ccacccucuc agcccagccc agcccugugg ugaccucagg aggaagggug      420

acccuccagu gugagucaca gguggcauuu ggcggcuuca uucuguguaa ggaaggagaa      480

gaagaacacc cacaaugccu gaacucccag ccccaugccc gugggucguc ccgcgccauc      540

uucuccgugg gccccgugag cccgaaucgc agguggucgc acaggugcua ugguuaugac      600

uugaacucuc ccuaugugug gucuucaccc agugaucucc uggagcuccu ggucccaggu      660

guuucuaaga agccaucacu cucagugcag ccggguccug ucguggcccc uggggaaagc      720

cugacccucc agugugucuc ugaugucggc uaugacagau uuguucugua caaggagggg      780

gaacgugacc uucgccagcu cccuggccgg cagccccagg cugggcucuc ccaggccaac      840

uucacccugg gcccugugag ccgcuccuac gggggccagu acagaugcua cggugcacac      900

aaccucuccu cugagugcuc ggcccccagc gacccccugg acauccugau cacaggacag      960

auccguggca cacccuucau cucagugcag ccaggcccca caguggccuc aggagagaac     1020

gugacccugc ugugucaguc auggcggcag uuccacacuu uccuucugac caaggcggga     1080

gcagcugaug ccccacuccg ucuaagauca auacacgaau auccuaagua ccaggcugaa     1140

uuccccauga guccugugac cucagcccac gcggggaccu acaggugcua cggcucacuc     1200

aacuccgacc ccuaccugcu gucucacccc agugagcccc uggagcucgu ggucucagga     1260

cccuccaugg guuccagccc cccacccacc ggucccaucu ccacaccugc aggcccugag     1320

gaccagcccc ucacccccac ugggucggau ccccaaagug gucugggaag gcaccugggg     1380

guugugaucg gcaucuuggu ggccgucguc cuacugcucc uccuccuccu ccuccucuuc     1440

cucauccucc gacaucgacg ucagggcaaa cacuggacau cgacccagag aaaggcugau     1500

uuccaacauc cugcaggggc uguggggcca gagcccacag acagaggccu gcaguggagg     1560

uccagcccag cugccgacgc ccaggaagaa aaccucuaug cugccgugaa ggacacacag     1620

ccugaagaug ggguggagau ggacacucgg gcugcugcau cugaagcccc ccaggaugug     1680

accuacgccc agcugcacag cuugacccuc agacggaagg caacugagcc uccuccaucc     1740

caggaaaggg aaccuccagc ugagcccagc aucuacgcca cccuggccau ccacuag        1797


<210>  2164
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LIRB2__Homo_sapiens__AAL36991

<400>  2164
augaccccca ucgugaccgu ccugaucugc cucggccuga gccuggggcc gcgcacgcac       60

gugcagaccg gcaccauccc caagcccacc cucugggccg agcccgacuc cgugaucacg      120

caggggagcc cggucacccu guccugccag ggcagccugg aggcccagga guaccggcuc      180

uaccgcgaga agaaguccgc gagcuggauc acccggaucc gccccgagcu ggugaagaac      240

gggcaguucc acauccccuc caucaccugg gagcacacgg gccgguacgg cugccaguac      300

uacagccgcg cccggugguc cgagcugagc gacccccucg ugcuggucau gaccggggcc      360

uacccgaagc ccacccuguc cgcccagccc agccccgugg ugaccuccgg cgggcgcguc      420

acgcuccagu gcgagagcca gguggccuuc ggcggguuca uccugugcaa ggagggcgag      480

gaggagcacc cgcagugccu gaacucccag ccccacgcgc ggggcagcuc ccgcgccauc      540

uucagcgugg ggcccgucuc ccccaaccgg cgcuggagcc accggugcua cggcuacgac      600

cucaacagcc cguacgugug guccagcccc uccgaccugc uggagcuccu ggugcccggg      660

gucagcaaga agcccucccu gagcgugcag ccgggccccg uggucgcccc cggcgagucc      720

cucacccugc agugcgugag cgacgugggg uacgaccgcu ucguccugua caaggagggc      780

gagcgggacc uccgccagcu gcccgggcgg cagccgcagg ccggccuguc ccaggcgaac      840

uucacccucg ggcccgugag ccgcuccuac ggcggccagu accggugcua cggggcccac      900

aaccugagcu ccgagugcag cgcccccucc gacccccugg acauccucau caccggccag      960

auccgcggga cgccguucau cagcgugcag cccggcccca ccgucgccuc cggggagaac     1020

gugacccugc ugugccagag cuggcggcag uuccacaccu uccuccugac gaaggccggc     1080

gcggccgacg ccccgcugcg ccuccgcucc auccacgagu accccaagua ccaggccgag     1140

uuccccauga gccccgucac cagcgcccac gcgggcaccu accggugcua cgggucccug     1200

aacagcgacc cguaccugcu cucccacccc agcgagcccc uggagcuggu gguguccggc     1260

cccagcaugg gguccagccc gccgcccacc ggccccaucu ccacgcccgc cgggcccgag     1320

gaccagcccc ucacccccac cggcagcgac ccgcaguccg gccuggggcg ccaccugggc     1380

gucgugaucg ggauccucgu ggccgucgug cugcugcucc ugcugcugcu ccugcuguuc     1440

cucauccugc ggcaccgccg gcagggcaag cacuggacca gcacgcagcg caaggccgac     1500

uuccagcacc ccgccggcgc gguggggccc gagcccaccg accggggccu gcaguggcgc     1560

uccagcccgg ccgccgacgc ccaggaggag aaccucuacg ccgcggucaa ggacacccag     1620

cccgaggacg ggguggagau ggacacccgg gccgccgccu ccgaggcgcc ccaggacgug     1680

acguacgccc agcugcacag ccugacccuc cgccggaagg ccaccgagcc cccgcccucc     1740

caggagcgcg agcccccggc cgagcccagc aucuacgcca cccuggcgau ccacuga        1797


<210>  2165
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LIRB2__Homo_sapiens__AAL36991

<400>  2165
augaccccca ucgucaccgu ccucaucugc cucggccucu cccucggccc ccgcacccac       60

guccagaccg gcaccauccc caagcccacc cucugggccg agcccgacuc cgucaucacc      120

cagggcuccc ccgucacccu cuccugccag ggcucccucg aggcccagga guaccgccuc      180

uaccgcgaga agaaguccgc cuccuggauc acccgcaucc gccccgagcu cgucaagaac      240

ggccaguucc acauccccuc caucaccugg gagcacaccg gccgcuacgg cugccaguac      300

uacucccgcg cccgcugguc cgagcucucc gacccccucg uccucgucau gaccggcgcc      360

uaccccaagc ccacccucuc cgcccagccc ucccccgucg ucaccuccgg cggccgcguc      420

acccuccagu gcgaguccca ggucgccuuc ggcggcuuca uccucugcaa ggagggcgag      480

gaggagcacc cccagugccu caacucccag ccccacgccc gcggcuccuc ccgcgccauc      540

uucuccgucg gccccgucuc ccccaaccgc cgcugguccc accgcugcua cggcuacgac      600

cucaacuccc ccuacgucug guccuccccc uccgaccucc ucgagcuccu cguccccggc      660

gucuccaaga agcccucccu cuccguccag cccggccccg ucgucgcccc cggcgagucc      720

cucacccucc agugcgucuc cgacgucggc uacgaccgcu ucguccucua caaggagggc      780

gagcgcgacc uccgccagcu ccccggccgc cagccccagg ccggccucuc ccaggccaac      840

uucacccucg gccccgucuc ccgcuccuac ggcggccagu accgcugcua cggcgcccac      900

aaccucuccu ccgagugcuc cgcccccucc gacccccucg acauccucau caccggccag      960

auccgcggca cccccuucau cuccguccag cccggcccca ccgucgccuc cggcgagaac     1020

gucacccucc ucugccaguc cuggcgccag uuccacaccu uccuccucac caaggccggc     1080

gccgccgacg ccccccuccg ccuccgcucc auccacgagu accccaagua ccaggccgag     1140

uuccccaugu cccccgucac cuccgcccac gccggcaccu accgcugcua cggcucccuc     1200

aacuccgacc ccuaccuccu cucccacccc uccgagcccc ucgagcucgu cgucuccggc     1260

cccuccaugg gcuccucccc cccccccacc ggccccaucu ccacccccgc cggccccgag     1320

gaccagcccc ucacccccac cggcuccgac ccccaguccg gccucggccg ccaccucggc     1380

gucgucaucg gcauccucgu cgccgucguc cuccuccucc uccuccuccu ccuccucuuc     1440

cucauccucc gccaccgccg ccagggcaag cacuggaccu ccacccagcg caaggccgac     1500

uuccagcacc ccgccggcgc cgucggcccc gagcccaccg accgcggccu ccaguggcgc     1560

uccucccccg ccgccgacgc ccaggaggag aaccucuacg ccgccgucaa ggacacccag     1620

cccgaggacg gcgucgagau ggacacccgc gccgccgccu ccgaggcccc ccaggacguc     1680

accuacgccc agcuccacuc ccucacccuc cgccgcaagg ccaccgagcc cccccccucc     1740

caggagcgcg agccccccgc cgagcccucc aucuacgcca cccucgccau ccacuga        1797


<210>  2166
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LIRB2__Homo_sapiens__AAL36991

<400>  2166
augaccccca ucgugacagu ccugauuugc cucggccuua gccuggggcc uagaacucac       60

guucagacgg gaaccauacc aaagccgaca uugugggccg agcccgacuc cgugaucacu      120

caagguucuc cuguaaccuu aucaugucag ggcagucugg aagcucagga guacaggcua      180

uaucgggaga aaaagagcgc auccuggauu acacgcaucc gaccagagcu cgugaaaaac      240

gggcaguucc auauucccuc uaucaccugg gaacacacug gacguuacgg cugccaauau      300

uacucgagag ccaggugguc agagcugagc gauccucuug uccuggugau gacaggugcg      360

uauccaaagc ccaccuugag ugcucagccu uccccaguug ugacgucugg gggacggguc      420

acucuccagu gugagagcca gguggccuuu ggcggcuuca uacugugcaa agaaggggag      480

gaagaacauc cgcaaugucu gaacucccag ccccacgcac gcggaucaag uagagccauc      540

uuuagcguag guccuguuuc uccaaauagg cggugguccc aucgcugcua cggcuaugac      600

cucaauucac ccuacgugug gagcaguccu ucugauuuac uggagcuuuu ggucccaggg      660

guguccaaga agcccagccu gucggugcag ccgggaccug ucguugcucc cggcgaaucu      720

cuaacccucc aguguguguc cgacguaggu uacgaucgau ucgugcugua uaaagagggg      780

gaaagagacc uuaggcaacu gccaggacgg cagccucagg caggcuuguc acaagccaac      840

uuuacacucg gccccgucag ucguagcuac gggggacagu aucgcugcua cggugcucac      900

aaucuguccu cugaguguag cgccccauca gaucccuuag acauucugau cacuggccag      960

auuagaggga ccccuuucau cagugugcag ccaggaccga caguugcguc cggcgaaaac     1020

gugacccucc uuugccaaag cuggaggcag uuucacacgu uccuguugac uaaggccggu     1080

gccgcugaug caccccuacg gcugcgaucu auacaugagu auccuaaaua ccaggcagag     1140

uuuccaaugu cacccgucac aagugcucac gccgggaccu aucgcuguua cggcagccuc     1200

aauuccgacc cuuaccugcu uucucaucca ucggaacccc uggaguuggu gguaagcgga     1260

ccguccaugg gcucaagucc uccacccacu gggccuauuu cuacacccgc gggaccagaa     1320

gaucagccuc ucacccccac ggguagcgac ccacaauccg gccuggggag acacuuagga     1380

guugugaucg gcauucuggu cgccgugguc cuacuccugc uuuugcugcu ccugcuuuuc     1440

cugaucuuga ggcaccggcg ccaggguaag cauuggaccu caacacagag aaaagcagau     1500

uuucagcacc cggcuggggc cgugggcccu gagcccacug acaggggacu ccaauggcgu     1560

agcucuccag cugccgacgc acaggaagag aaccuguaug ccgcuguuaa ggauacccag     1620

cccgaggacg gcguggaaau ggauacacgg gcggcagccu ccgaggcucc ucaggacgua     1680

acuuacgccc aauuacauag ucugacccua cgaagaaagg caacagaacc acccccuagc     1740

caggagaggg aaccgccagc cgagcccucu aucuaugcua cccucgccau ucacuga        1797


<210>  2167
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LIRB2__Homo_sapiens__AAL36991

<400>  2167
augaccccca ucgugaccgu gcugaucugc cugggccuga gccugggccc cagaacccac       60

gugcagaccg gcaccauccc caagcccacc cugugggccg agcccgacag cgugaucacc      120

cagggcagcc ccgugacccu gagcugccag ggcagccugg aggcccagga guacagacug      180

uacagagaga agaagagcgc cagcuggauc accagaauca gacccgagcu ggugaagaac      240

ggccaguucc acauccccag caucaccugg gagcacaccg gcagauacgg cugccaguac      300

uacagcagag ccagauggag cgagcugagc gacccccugg ugcuggugau gaccggcgcc      360

uaccccaagc ccacccugag cgcccagccc agccccgugg ugaccagcgg cggcagagug      420

acccugcagu gcgagagcca gguggccuuc ggcggcuuca uccugugcaa ggagggcgag      480

gaggagcacc cccagugccu gaacagccag ccccacgcca gaggcagcag cagagccauc      540

uucagcgugg gccccgugag ccccaacaga agauggagcc acagaugcua cggcuacgac      600

cugaacagcc ccuacgugug gagcagcccc agcgaccugc uggagcugcu ggugcccggc      660

gugagcaaga agcccagccu gagcgugcag cccggccccg ugguggcccc cggcgagagc      720

cugacccugc agugcgugag cgacgugggc uacgacagau ucgugcugua caaggagggc      780

gagagagacc ugagacagcu gcccggcaga cagccccagg ccggccugag ccaggccaac      840

uucacccugg gccccgugag cagaagcuac ggcggccagu acagaugcua cggcgcccac      900

aaccugagca gcgagugcag cgcccccagc gacccccugg acauccugau caccggccag      960

aucagaggca cccccuucau cagcgugcag cccggcccca ccguggccag cggcgagaac     1020

gugacccugc ugugccagag cuggagacag uuccacaccu uccugcugac caaggccggc     1080

gccgccgacg ccccccugag acugagaagc auccacgagu accccaagua ccaggccgag     1140

uuccccauga gccccgugac cagcgcccac gccggcaccu acagaugcua cggcagccug     1200

aacagcgacc ccuaccugcu gagccacccc agcgagcccc uggagcuggu ggugagcggc     1260

cccagcaugg gcagcagccc cccccccacc ggccccauca gcacccccgc cggccccgag     1320

gaccagcccc ugacccccac cggcagcgac ccccagagcg gccugggcag acaccugggc     1380

guggugaucg gcauccuggu ggccguggug cugcugcugc ugcugcugcu gcugcuguuc     1440

cugauccuga gacacagaag acagggcaag cacuggacca gcacccagag aaaggccgac     1500

uuccagcacc ccgccggcgc cgugggcccc gagcccaccg acagaggccu gcaguggaga     1560

agcagccccg ccgccgacgc ccaggaggag aaccuguacg ccgccgugaa ggacacccag     1620

cccgaggacg gcguggagau ggacaccaga gccgccgcca gcgaggcccc ccaggacgug     1680

accuacgccc agcugcacag ccugacccug agaagaaagg ccaccgagcc cccccccagc     1740

caggagagag agccccccgc cgagcccagc aucuacgcca cccuggccau ccacuga        1797


<210>  2168
<211>  1797
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LIRB2__Homo_sapiens__AAL36991

<400>  2168
augaccccca ucgugacagu ccugauuugc cucggccuga gccuugggcc uagaacgcac       60

guucagaccg gaacaauccc gaagcccacc cugugggccg agccugacuc cgugauuaca      120

caaggcucuc ccgugacccu cagcugucag gggucccugg aagcucagga guaccggcuu      180

uaucgcgaga aaaagucugc cagcuggauc acacggauua gaccugagcu ggucaaaaac      240

ggacaguucc auauccccuc caucaccugg gaacacacgg gccgcuacgg gugccaauau      300

uacucuagag cgcgguggag cgagcucucc gauccucugg ugcugguuau gaccggagcu      360

uauccgaagc ccacacucag cgcccagccu ucucccgugg ucaccuccgg cggccgcgug      420

acacugcagu gugagagcca gguugccuuu gggggauuca uucuuugcaa agaaggcgag      480

gaagaacauc cucaaugucu gaacucucag ccccacgcua gaggguccag ccgggccauc      540

uuuucugugg gaccggucuc cccuaaucgc agauggagcc aucggugcua cggcuaugac      600

cucaauuccc ccuacgugug gucuagcccu uccgaucugc uugagcugcu cgugcccggg      660

gucagcaaga agcccucucu guccguucag ccuggaccgg ugguggcucc cggcgaaagc      720

cugacccucc agugugucuc ugacgugggc uacgaucgcu ucguucugua uaaagagggg      780

gaaagagacc uucggcaacu gccuggacgc cagccccagg ccggccucag ccaagcgaac      840

uuuacgcugg ggccuguguc cagaucuuac ggaggccagu aucggugcua cggggcccac      900

aaucuuagcu ccgaguguag cgcucccucu gauccgcugg acauucucau cacaggacag      960

auuagaggca ccccuuucau cuccguccag cccggcccua caguggccag cggggaaaac     1020

guuacccugc ugugccaauc uuggcgccag uuucacaccu uccuccugac aaaggcugga     1080

gccgcggaug cuccccuucg gcugagaucc auucaugagu auccuaaaua ccaggccgag     1140

uuucccauga gcccggugac guccgcccac gcuggcaccu aucgcuguua cgggucucuc     1200

aauagcgacc cuuaccugcu uucccauccc ucugaacccc uggagcucgu cgugagcgga     1260

ccuuccaugg gcagcucucc gcccccuaca gggcccaucu ccaccccugc cggccccgaa     1320

gaucagccuc ugacacccac cggaagcgac ccgcaaucug gccuggggcg gcaccucgga     1380

gucgugaucg gcauucuggu ugccgugguc cuucugcucc ugcugcuucu ccugcuguuc     1440

cucauccuga gacaccgccg gcaggggaag cauuggacgu ccacacagag aaaagcugau     1500

uuucagcacc cugcgggagc cgugggcccc gagccuaccg accgcgggcu ucaauggcgg     1560

agcucucccg cugccgacgc ccaggaagag aaccuguaug cugccguuaa ggauacccag     1620

ccggaggacg gcguggaaau ggauacaaga gcggcugcca gcgaggcccc ucaggacguc     1680

accuacgcuc aacuccauuc ccugacacug cgccggaagg ccacggaacc cccucccagc     1740

caggagagag aacccccugc ugagccgucu auuuaugcca cccuugcgau ccacuga        1797


<210>  2169
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LY6K__Homo_sapiens__Q17RY6

<400>  2169

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Lys Ile Phe Pro Arg Phe Phe Met 
65                  70                  75                  80  


Val Ala Lys Gln Cys Ser Ala Gly Cys Ala Ala Met Glu Arg Pro Lys 
                85                  90                  95      


Pro Glu Glu Lys Arg Phe Leu Leu Glu Glu Pro Met Pro Phe Phe Tyr 
            100                 105                 110         


Leu Lys Cys Cys Lys Ile Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
        115                 120                 125             


Asn Ser Ser Val Phe Lys Glu Tyr Ala Gly Ser Met Gly Glu Ser Cys 
    130                 135                 140                 


Gly Gly Leu Trp Leu Ala Ile Leu Leu Leu Leu Ala Ser Ile Ala Ala 
145                 150                 155                 160 


Gly Leu Ser Leu Ser 
                165 


<210>  2170
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LY6K__Homo_sapiens__CCDS6385.2

<400>  2170
auggcgcugc ucgccuugcu gcuggucgug gcccuaccgc ggguguggac agacgccaac       60

cugacugcga gacaacgaga uccagaggac ucccagcgaa cggacgaggg ugacaauaga      120

gugugguguc auguuuguga gagagaaaac acuuucgagu gccagaaccc aaggaggugc      180

aaauggacag agccauacug cguuauagcg gccgugaaaa uauuuccacg uuuuuucaug      240

guugcgaagc agugcuccgc ugguugugca gcgauggaga gacccaagcc agaggagaag      300

cgguuucucc uggaagagcc caugcccuuc uuuuaccuca aguguuguaa aauucgcuac      360

ugcaauuuag aggggccacc uaucaacuca ucaguguuca aagaauaugc ugggagcaug      420

ggugagagcu guggugggcu guggcuggcc auccuccugc ugcuggccuc cauugcagcc      480

ggccucagcc ugucuuga                                                    498


<210>  2171
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LY6K__Homo_sapiens__CCDS6385.2

<400>  2171
auggcccugc ucgcccugcu gcucgugguc gcgcugcccc gcguguggac cgacgccaac       60

cugaccgccc ggcagcgcga cccggaggac agccagcgga cggacgaggg cgacaaccgc      120

guguggugcc acgucugcga gcgggagaac accuucgagu gccagaaccc ccgccggugc      180

aaguggaccg agcccuacug cgugaucgcc gccgugaaga ucuucccccg cuucuucaug      240

gucgcgaagc agugcuccgc cgggugcgcc gccauggagc ggccgaagcc cgaggagaag      300

cgcuuccucc uggaggagcc caugcccuuc uucuaccuga agugcugcaa gauccgguac      360

ugcaaccucg agggcccgcc caucaacagc uccguguuca aggaguacgc ggggagcaug      420

ggcgaguccu gcgggggccu guggcuggcc auccuccugc ugcucgccag caucgccgcc      480

ggccuguccc ugagcuga                                                    498


<210>  2172
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LY6K__Homo_sapiens__CCDS6385.2

<400>  2172
auggcccucc ucgcccuccu ccucgucguc gcccuccccc gcgucuggac cgacgccaac       60

cucaccgccc gccagcgcga ccccgaggac ucccagcgca ccgacgaggg cgacaaccgc      120

gucuggugcc acgucugcga gcgcgagaac accuucgagu gccagaaccc ccgccgcugc      180

aaguggaccg agcccuacug cgucaucgcc gccgucaaga ucuucccccg cuucuucaug      240

gucgccaagc agugcuccgc cggcugcgcc gccauggagc gccccaagcc cgaggagaag      300

cgcuuccucc ucgaggagcc caugcccuuc uucuaccuca agugcugcaa gauccgcuac      360

ugcaaccucg agggcccccc caucaacucc uccgucuuca aggaguacgc cggcuccaug      420

ggcgaguccu gcggcggccu cuggcucgcc auccuccucc uccucgccuc caucgccgcc      480

ggccucuccc ucuccuga                                                    498


<210>  2173
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LY6K__Homo_sapiens__CCDS6385.2

<400>  2173
auggcccugc ucgcacuucu guuggugguc gcuuuaccca gaguuuggac cgacgccaac       60

cugacagcga ggcagcggga uccugaggac agccaacgca cugaugaagg cgacaaucga      120

guguggugcc acguauguga gcgugaaaac acguucgagu gccagaaucc aagaaggugu      180

aaguggaccg aaccguacug cgugaucgcu gccgucaaaa uuuuuccccg guucuuuaug      240

guggcaaagc aguguuccgc cgggugcgcu gcaauggagc gcccuaaacc agaggaaaag      300

agauuccuac ucgaggaacc caugccauuu uucuaucuga aauguugcaa gauaagguac      360

uguaaccuug agggaccucc caucaauucu ucaguuuuua aggaguaugc cgguaguaug      420

ggcgaaagcu gcgggggacu gugguuggcu auucuccugc ugcucgccuc caucgcggca      480

ggcuuaucuc ugucguga                                                    498


<210>  2174
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LY6K__Homo_sapiens__CCDS6385.2

<400>  2174
auggcccugc uggcccugcu gcugguggug gcccugccca gaguguggac cgacgccaac       60

cugaccgcca gacagagaga ccccgaggac agccagagaa ccgacgaggg cgacaacaga      120

guguggugcc acgugugcga gagagagaac accuucgagu gccagaaccc cagaagaugc      180

aaguggaccg agcccuacug cgugaucgcc gccgugaaga ucuuccccag auucuucaug      240

guggccaagc agugcagcgc cggcugcgcc gccauggaga gacccaagcc cgaggagaag      300

agauuccugc uggaggagcc caugcccuuc uucuaccuga agugcugcaa gaucagauac      360

ugcaaccugg agggcccccc caucaacagc agcguguuca aggaguacgc cggcagcaug      420

ggcgagagcu gcggcggccu guggcuggcc auccugcugc ugcuggccag caucgccgcc      480

ggccugagcc ugagcuga                                                    498


<210>  2175
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LY6K__Homo_sapiens__CCDS6385.2

<400>  2175
auggcccugc ucgcucugcu ucuggugguc gcccucccca gaguuuggac cgacgcgaac       60

cugacagcuc ggcagcgcga uccugaggac agccaaagaa cggaugaagg cgacaaucgg      120

guguggugcc acguguguga gcgcgaaaac accuucgagu gccagaaucc gagacggugu      180

aaguggacag aacccuacug cgucaucgcc gccgugaaaa uuuuuccucg cuucuuuaug      240

guugcuaagc aguguuccgc cgggugcgcu gccauggaga gacccaaacc ugaggaaaag      300

cgguuccuuc uggaggaacc caugccguuu uucuaucuca aauguugcaa gauccgcuac      360

uguaaccugg agggaccucc cauuaauucu agcguguuua aggaguaugc gggcuccaug      420

ggggaaucuu gcggaggccu guggcucgcc auccugcuuc ugcucgcuag cauugccgcu      480

gggcuguccc uuucuuga                                                    498


<210>  2176
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGA5__Homo_sapiens__P43359

<400>  2176

Met Ser Leu Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Asp Thr Gln Glu Glu Ala Leu Gly Leu Val Gly Val Gln Ala Ala Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Val Ser Ser Ser Ser Pro Leu Val Pro Gly 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Gly Ser Pro Gly Pro Leu Lys Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ala Ile Pro Thr Ala Ile Asp Phe Thr Leu Trp 
65                  70                  75                  80  


Arg Gln Ser Ile Lys Gly Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Ser Pro Asp Pro Glu Ser Val Phe Arg Ala Ala Leu Ser Lys Lys 
            100                 105                 110         


Val Ala Asp Leu Ile His Phe Leu Leu Leu Lys Tyr 
        115                 120                 


<210>  2177
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGA5__Homo_sapiens__AAA68873

<400>  2177
augucucuug agcagaagag ucagcacugc aagccugagg aaggccuuga cacccaagaa       60

gaggcccugg gccugguggg ugugcaggcu gccacuacug aggagcagga ggcugugucc      120

uccuccucuc cucugguccc aggcacccug ggggaggugc cugcugcugg gucaccaggu      180

ccucucaaga guccucaggg agccuccgcc auccccacug ccaucgauuu cacucuaugg      240

aggcaaucca uuaagggcuc cagcaaccaa gaagaggagg ggccaagcac cuccccugac      300

ccagagucug uguuccgagc agcacucagu aagaaggugg cugacuugau ucauuuucug      360

cuccucaagu auuaa                                                       375


<210>  2178
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGA5__Homo_sapiens__AAA68873

<400>  2178
augagccugg agcagaaguc ccagcacugc aagcccgagg agggccucga cacccaggag       60

gaggcccugg ggcugguggg cguccaggcc gcgaccacgg aggagcagga ggccgugagc      120

uccagcuccc cgcucgugcc cgggacccug ggcgaggucc ccgccgccgg gagccccggc      180

ccgcugaagu ccccgcaggg cgccagcgcg auccccaccg ccaucgacuu cacccucugg      240

cgccagucca ucaaggggag cuccaaccag gaggaggagg gccccagcac gucccccgac      300

cccgagagcg uguuccgggc cgcccugucc aagaaggugg cggaccugau ccacuuccuc      360

cugcugaagu acuga                                                       375


<210>  2179
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGA5__Homo_sapiens__AAA68873

<400>  2179
augucccucg agcagaaguc ccagcacugc aagcccgagg agggccucga cacccaggag       60

gaggcccucg gccucgucgg cguccaggcc gccaccaccg aggagcagga ggccgucucc      120

uccuccuccc cccucguccc cggcacccuc ggcgaggucc ccgccgccgg cucccccggc      180

ccccucaagu ccccccaggg cgccuccgcc auccccaccg ccaucgacuu cacccucugg      240

cgccagucca ucaagggcuc cuccaaccag gaggaggagg gccccuccac cucccccgac      300

cccgaguccg ucuuccgcgc cgcccucucc aagaaggucg ccgaccucau ccacuuccuc      360

cuccucaagu acuga                                                       375


<210>  2180
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGA5__Homo_sapiens__AAA68873

<400>  2180
augagccugg agcagaaguc ccaacacugc aaacccgaag agggccucga cacccaggaa       60

gaggcccuug ggcugguggg aguccaggcu gcaacaacug aggaacagga ggccguuucu      120

ucaaguagcc cuuuggugcc agguacguua ggcgaaguac cggcggcugg gucccccgga      180

ccucugaagu cuccacaagg cgccucggca auccccaccg ccauugauuu cacacuaugg      240

agacagucaa uaaaagguag caguaaccag gaggaagagg ggccuuccac uucuccagac      300

cccgagagcg uguuuagggc ugcacucucc aagaaagucg ccgaucugau ccauuuccuu      360

cuguugaagu acuga                                                       375


<210>  2181
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGA5__Homo_sapiens__AAA68873

<400>  2181
augagccugg agcagaagag ccagcacugc aagcccgagg agggccugga cacccaggag       60

gaggcccugg gccugguggg cgugcaggcc gccaccaccg aggagcagga ggccgugagc      120

agcagcagcc cccuggugcc cggcacccug ggcgaggugc ccgccgccgg cagccccggc      180

ccccugaaga gcccccaggg cgccagcgcc auccccaccg ccaucgacuu cacccugugg      240

agacagagca ucaagggcag cagcaaccag gaggaggagg gccccagcac cagccccgac      300

cccgagagcg uguucagagc cgcccugagc aagaaggugg ccgaccugau ccacuuccug      360

cugcugaagu acuga                                                       375


<210>  2182
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGA5__Homo_sapiens__AAA68873

<400>  2182
augagccugg agcagaaguc ccaacacugc aaacccgaag agggccucga cacccaggaa       60

gaggcccugg ggcuuguggg aguccaggcu gccacaacgg aggaacagga ggcgguuucu      120

agcuccucuc cucuggugcc gggcacccuc ggggaagugc ccgcugccgg aagcccuggc      180

ccccugaagu ccccucaagg ggccucugcu auccccacag ccauugauuu cacccuuugg      240

agacagagca ucaaaggauc cagcaaccag gaggaagagg gcccuucuac auccccggac      300

cccgagagcg ucuuucgggc ugcccugucu aagaaagugg cggaucucau ucauuuccug      360

cugcucaagu acuga                                                       375


<210>  2183
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGA8__Homo_sapiens__P43361

<400>  2183

Met Leu Leu Gly Gln Lys Ser Gln Arg Tyr Lys Ala Glu Glu Gly Leu 
1               5                   10                  15      


Gln Ala Gln Gly Glu Ala Pro Gly Leu Met Asp Val Gln Ile Pro Thr 
            20                  25                  30          


Ala Glu Glu Gln Lys Ala Ala Ser Ser Ser Ser Thr Leu Ile Met Gly 
        35                  40                  45              


Thr Leu Glu Glu Val Thr Asp Ser Gly Ser Pro Ser Pro Pro Gln Ser 
    50                  55                  60                  


Pro Glu Gly Ala Ser Ser Ser Leu Thr Val Thr Asp Ser Thr Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Asp Glu Gly Ser Ser Ser Asn Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Ser Pro Asp Pro Ala His Leu Glu Ser Leu Phe Arg Glu Ala Leu 
            100                 105                 110         


Asp Glu Lys Val Ala Glu Leu Val Arg Phe Leu Leu Arg Lys Tyr Gln 
        115                 120                 125             


Ile Lys Glu Pro Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys 
    130                 135                 140                 


Asn Tyr Lys Asn His Phe Pro Asp Ile Phe Ser Lys Ala Ser Glu Cys 
145                 150                 155                 160 


Met Gln Val Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Gly 
                165                 170                 175     


His Ser Tyr Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu 
            180                 185                 190         


Leu Gly Asp Asp Gln Ser Thr Pro Lys Thr Gly Leu Leu Ile Ile Val 
        195                 200                 205             


Leu Gly Met Ile Leu Met Glu Gly Ser Arg Ala Pro Glu Glu Ala Ile 
    210                 215                 220                 


Trp Glu Ala Leu Ser Val Met Gly Leu Tyr Asp Gly Arg Glu His Ser 
225                 230                 235                 240 


Val Tyr Trp Lys Leu Arg Lys Leu Leu Thr Gln Glu Trp Val Gln Glu 
                245                 250                 255     


Asn Tyr Leu Glu Tyr Arg Gln Ala Pro Gly Ser Asp Pro Val Arg Tyr 
            260                 265                 270         


Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys 
        275                 280                 285             


Val Leu Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ser Tyr 
    290                 295                 300                 


Pro Ser Leu His Glu Glu Ala Leu Gly Glu Glu Lys Gly Val 
305                 310                 315             


<210>  2184
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGA8__Homo_sapiens__AAH02455

<400>  2184
augcuucuug ggcagaagag ucagcgcuac aaggcugagg aaggccuuca ggcccaagga       60

gaggcaccag ggcuuaugga ugugcagauu cccacagcug aggagcagaa ggcugcaucc      120

uccuccucua cucugaucau gggaacccuu gaggagguga cugauucugg gucaccaagu      180

ccuccccaga guccugaggg ugccuccucu ucccugacug ucaccgacag cacucugugg      240

agccaauccg augaggguuc cagcagcaau gaagaggagg ggccaagcac cuccccggac      300

ccagcucacc uggagucccu guuccgggaa gcacuugaug agaaaguggc ugaguuaguu      360

cguuuccugc uccgcaaaua ucaaauuaag gagccgguca caaaggcaga aaugcuugag      420

agugucauca aaaauuacaa gaaccacuuu ccugauaucu ucagcaaagc cucugagugc      480

augcagguga ucuuuggcau ugaugugaag gaaguggacc cugccggcca cuccuacauc      540

cuugucaccu gccugggccu cuccuaugau ggccugcugg gugaugauca gaguacgccc      600

aagaccggcc uccugauaau cguccugggc augaucuuaa uggagggcag ccgcgccccg      660

gaggaggcaa ucugggaagc guugagugug auggggcugu augaugggag ggagcacagu      720

gucuauugga agcucaggaa gcugcucacc caagaguggg ugcaggagaa cuaccuggag      780

uaccgccagg cgcccggcag ugauccugug cgcuacgagu uccugugggg uccaagggcc      840

cuugcugaaa ccagcuaugu gaaaguccug gagcaugugg ucagggucaa ugcaagaguu      900

cgcauuuccu acccaucccu gcaugaagag gcuuugggag aggagaaagg aguuuga         957


<210>  2185
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGA8__Homo_sapiens__AAH02455

<400>  2185
augcugcucg gccagaaguc ccagcgcuac aaggccgagg aggggcugca ggcccagggc       60

gaggcgcccg ggcugaugga cgugcagauc ccgaccgccg aggagcagaa ggccgccagc      120

agcuccagca cccucaucau gggcacgcug gaggagguca ccgacuccgg gagccccucc      180

ccgccccaga gccccgaggg cgccuccagc ucccugaccg ugaccgacag cacgcucugg      240

ucccagagcg acgagggcuc cagcuccaac gaggaggagg ggcccagcac cucccccgac      300

cccgcgcacc uggagagccu guuccgggag gcccucgacg agaagguggc cgagcugguc      360

cgcuuccugc uccggaagua ccagaucaag gagccgguga ccaaggccga gaugcuggag      420

agcgugauca agaacuacaa gaaccacuuc cccgacaucu ucuccaaggc gagcgagugc      480

augcagguca ucuucggcau cgacgugaag gagguggacc ccgccgggca cuccuacauc      540

cuggugaccu gccucggccu gagcuacgac gggcugcucg gcgacgacca guccacgccc      600

aagaccggcc ugcugaucau cguccucggg augauccuga uggagggcag ccgcgccccg      660

gaggaggcca ucugggaggc ccuguccgug auggggcucu acgacggccg ggagcacagc      720

gucuacugga agcugcgcaa gcugcucacc caggaguggg ugcaggagaa cuaccuggag      780

uaccggcagg cgcccggcuc cgaccccgug cgcuacgagu uccugugggg gccccgggcc      840

cucgccgaga ccagcuacgu caaggugcug gagcacgugg uccgcgugaa cgcccgggug      900

cgcaucuccu acccgagccu gcacgaggag gcccucggcg aggagaaggg ggucuga         957


<210>  2186
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGA8__Homo_sapiens__AAH02455

<400>  2186
augcuccucg gccagaaguc ccagcgcuac aaggccgagg agggccucca ggcccagggc       60

gaggcccccg gccucaugga cguccagauc cccaccgccg aggagcagaa ggccgccucc      120

uccuccucca cccucaucau gggcacccuc gaggagguca ccgacuccgg cucccccucc      180

cccccccagu cccccgaggg cgccuccucc ucccucaccg ucaccgacuc cacccucugg      240

ucccaguccg acgagggcuc cuccuccaac gaggaggagg gccccuccac cucccccgac      300

cccgcccacc ucgagucccu cuuccgcgag gcccucgacg agaaggucgc cgagcucguc      360

cgcuuccucc uccgcaagua ccagaucaag gagcccguca ccaaggccga gaugcucgag      420

uccgucauca agaacuacaa gaaccacuuc cccgacaucu ucuccaaggc cuccgagugc      480

augcagguca ucuucggcau cgacgucaag gaggucgacc ccgccggcca cuccuacauc      540

cucgucaccu gccucggccu cuccuacgac ggccuccucg gcgacgacca guccaccccc      600

aagaccggcc uccucaucau cguccucggc augauccuca uggagggcuc ccgcgccccc      660

gaggaggcca ucugggaggc ccucuccguc augggccucu acgacggccg cgagcacucc      720

gucuacugga agcuccgcaa gcuccucacc caggaguggg uccaggagaa cuaccucgag      780

uaccgccagg cccccggcuc cgaccccguc cgcuacgagu uccucugggg cccccgcgcc      840

cucgccgaga ccuccuacgu caagguccuc gagcacgucg uccgcgucaa cgcccgcguc      900

cgcaucuccu accccucccu ccacgaggag gcccucggcg aggagaaggg cgucuga         957


<210>  2187
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGA8__Homo_sapiens__AAH02455

<400>  2187
augcugcucg gccaaaagag ccagagauac aaagccgagg aagggcuuca ggcucaggga       60

gaggcacccg gucugaugga cgugcagauc ccuaccgccg aggaacaaaa ggcggcuucc      120

ucuucaagua cauugauuau gggcacuuua gaagagguca cggauagcgg guccccaucu      180

ccgccccagu cgccugaggg agccucaagc agucugaccg uuacagacuc cacucuaugg      240

ucucagagcg augaaggcuc cucaaguaac gaggaagagg guccaagcac cucucccgac      300

ccugcacacc ucgagucccu guucagggaa gcccuugaug agaaaguggc ugaacuggua      360

cgguuuuugc uccgcaagua ucagauaaaa gagccaguga caaaggcaga aaugcuggag      420

ucagucauca agaauuacaa aaaccauuuc cccgacauuu uuagcaaggc cagugagugc      480

augcaaguga ucuucgggau ugauguuaaa gaaguggacc cugcuggaca cucuuauauc      540

cuggucaccu gucucggcuu auccuacgau ggccugcuug gggacgauca gagcacucca      600

aagacaggau ugcugauaau cgugcuaggu augauucuca uggagggcuc gcgagccccg      660

gaagaggcga ucugggaagc acugucugua auggggcuuu augacggacg ugagcauucc      720

guuuacugga aacugagaaa guugcucacc caggaguggg ugcaggaaaa uuaucuggag      780

uacaggcaag cccccggcuc agauccuguc cgguacgaau uuuuaugggg uccacgcgcu      840

cuggccgaga cgaguuaugu gaaggugcuc gaacacgucg uuagagugaa cgcaagggua      900

cggauuagcu accccucccu ucaugaggag gcucuggggg aagagaaagg aguguga         957


<210>  2188
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGA8__Homo_sapiens__AAH02455

<400>  2188
augcugcugg gccagaagag ccagagauac aaggccgagg agggccugca ggcccagggc       60

gaggcccccg gccugaugga cgugcagauc cccaccgccg aggagcagaa ggccgccagc      120

agcagcagca cccugaucau gggcacccug gaggagguga ccgacagcgg cagccccagc      180

cccccccaga gccccgaggg cgccagcagc agccugaccg ugaccgacag cacccugugg      240

agccagagcg acgagggcag cagcagcaac gaggaggagg gccccagcac cagccccgac      300

cccgcccacc uggagagccu guucagagag gcccuggacg agaagguggc cgagcuggug      360

agauuccugc ugagaaagua ccagaucaag gagcccguga ccaaggccga gaugcuggag      420

agcgugauca agaacuacaa gaaccacuuc cccgacaucu ucagcaaggc cagcgagugc      480

augcagguga ucuucggcau cgacgugaag gagguggacc ccgccggcca cagcuacauc      540

cuggugaccu gccugggccu gagcuacgac ggccugcugg gcgacgacca gagcaccccc      600

aagaccggcc ugcugaucau cgugcugggc augauccuga uggagggcag cagagccccc      660

gaggaggcca ucugggaggc ccugagcgug augggccugu acgacggcag agagcacagc      720

guguacugga agcugagaaa gcugcugacc caggaguggg ugcaggagaa cuaccuggag      780

uacagacagg cccccggcag cgaccccgug agauacgagu uccugugggg ccccagagcc      840

cuggccgaga ccagcuacgu gaaggugcug gagcacgugg ugagagugaa cgccagagug      900

agaaucagcu accccagccu gcacgaggag gcccugggcg aggagaaggg cguguga         957


<210>  2189
<211>  957
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGA8__Homo_sapiens__AAH02455

<400>  2189
augcugcucg gccaaaagag ccagagauac aaagccgagg aagggcugca ggcucaggga       60

gaggcccccg gccuuaugga cgugcagauc ccuaccgcgg aggaacaaaa ggcugccucc      120

ucuagcucca cacugauuau ggggacgcuc gaagagguca ccgauucugg aagcccgucu      180

cccccucagu cccccgaggg cgccagcucc agccugacag uuaccgacuc uacacuuugg      240

ucccagagcg augaaggguc uuccagcaac gaggaagagg gaccuucuac cucccccgac      300

ccugcucacc uggagagccu cuuccgggaa gcccuggaug agaaaguggc ugaacuggug      360

cgcuuucucc ugagaaagua ucagaucaaa gagccgguca caaaggccga aaugcuugag      420

uccgugauua agaauuacaa aaaccauuuc cccgacaucu uuucuaaggc gagcgagugc      480

augcaaguua uuuucggcau cgaugugaaa gaagucgacc cugccggcca cuccuauauc      540

cuggugaccu gucucgggcu gagcuacgau ggacuucugg gcgacgauca gucuacgccc      600

aagaccgggc uccugauuau cguucuggga augauucuca uggagggcuc ccgggcuccu      660

gaagaggcca ucugggaagc ucugagcgug auggggcuuu augacggacg cgagcauucu      720

gucuacugga aacugagaaa gcuccugaca caggaguggg ugcaggaaaa uuaucuugag      780

uaccggcaag cccccggcag cgauccggug cgcuacgaau uucugugggg cccuagagcg      840

cucgccgaga ccuccuaugu caagguucug gaacacgugg ugcgggucaa cgcucgcgug      900

agaauuucuu accccagccu gcaugaggag gcccucgggg aagagaaagg aguuuga         957


<210>  2190
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGAB__Homo_sapiens__P43364

<400>  2190

Met Glu Thr Gln Phe Arg Arg Gly Gly Leu Gly Cys Ser Pro Ala Ser 
1               5                   10                  15      


Ile Lys Arg Lys Lys Lys Arg Glu Asp Ser Gly Asp Phe Gly Leu Gln 
            20                  25                  30          


Val Ser Thr Met Phe Ser Glu Asp Asp Phe Gln Ser Thr Glu Arg Ala 
        35                  40                  45              


Pro Tyr Gly Pro Gln Leu Gln Trp Ser Gln Asp Leu Pro Arg Val Gln 
    50                  55                  60                  


Val Phe Arg Glu Gln Ala Asn Leu Glu Asp Arg Ser Pro Arg Arg Thr 
65                  70                  75                  80  


Gln Arg Ile Thr Gly Gly Glu Gln Val Leu Trp Gly Pro Ile Thr Gln 
                85                  90                  95      


Ile Phe Pro Thr Val Arg Pro Ala Asp Leu Thr Arg Val Ile Met Pro 
            100                 105                 110         


Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu Gln Ala 
        115                 120                 125             


Gln Glu Glu Asp Leu Gly Leu Val Gly Ala Gln Ala Leu Gln Ala Glu 
    130                 135                 140                 


Glu Gln Glu Ala Ala Phe Phe Ser Ser Thr Leu Asn Val Gly Thr Leu 
145                 150                 155                 160 


Glu Glu Leu Pro Ala Ala Glu Ser Pro Ser Pro Pro Gln Ser Pro Gln 
                165                 170                 175     


Glu Glu Ser Phe Ser Pro Thr Ala Met Asp Ala Ile Phe Gly Ser Leu 
            180                 185                 190         


Ser Asp Glu Gly Ser Gly Ser Gln Glu Lys Glu Gly Pro Ser Thr Ser 
        195                 200                 205             


Pro Asp Leu Ile Asp Pro Glu Ser Phe Ser Gln Asp Ile Leu His Asp 
    210                 215                 220                 


Lys Ile Ile Asp Leu Val His Leu Leu Leu Arg Lys Tyr Arg Val Lys 
225                 230                 235                 240 


Gly Leu Ile Thr Lys Ala Glu Met Leu Gly Ser Val Ile Lys Asn Tyr 
                245                 250                 255     


Glu Asp Tyr Phe Pro Glu Ile Phe Arg Glu Ala Ser Val Cys Met Gln 
            260                 265                 270         


Leu Leu Phe Gly Ile Asp Val Lys Glu Val Asp Pro Thr Ser His Ser 
        275                 280                 285             


Tyr Val Leu Val Thr Ser Leu Asn Leu Ser Tyr Asp Gly Ile Gln Cys 
    290                 295                 300                 


Asn Glu Gln Ser Met Pro Lys Ser Gly Leu Leu Ile Ile Val Leu Gly 
305                 310                 315                 320 


Val Ile Phe Met Glu Gly Asn Cys Ile Pro Glu Glu Val Met Trp Glu 
                325                 330                 335     


Val Leu Ser Ile Met Gly Val Tyr Ala Gly Arg Glu His Phe Leu Phe 
            340                 345                 350         


Gly Glu Pro Lys Arg Leu Leu Thr Gln Asn Trp Val Gln Glu Lys Tyr 
        355                 360                 365             


Leu Val Tyr Arg Gln Val Pro Gly Thr Asp Pro Ala Cys Tyr Glu Phe 
    370                 375                 380                 


Leu Trp Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val Leu 
385                 390                 395                 400 


Glu Tyr Ile Ala Asn Ala Asn Gly Arg Asp Pro Thr Ser Tyr Pro Ser 
                405                 410                 415     


Leu Tyr Glu Asp Ala Leu Arg Glu Glu Gly Glu Gly Val 
            420                 425                 


<210>  2191
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGAB__Homo_sapiens__AAH04479

<400>  2191
auggagacuc aguuccgcag agggggucug gggugcagcc cugccagcau caagaggaag       60

aagaagaggg aggacucagg agacuuugga cuccagguga gcacuauguu cucagaggac      120

gacuuccagu caacagaaag agccccauau gguccacaac uacagugguc ccaggaucug      180

ccaagagucc agguuuuuag agaacaggcc aaccuggagg acaggagucc caggagaacc      240

cagaggauca cuggaggaga acaagugcug uggggcccca ucacccagau auuucccaca      300

guucggccug cugaccuaac cagagucauc augccucuug agcaaagaag ucagcacugc      360

aagccugagg aaggccuuca ggcccaagaa gaagaccugg gccugguggg ugcacaggcu      420

cuccaagcug aggagcagga ggcugccuuc uucuccucua cucugaaugu gggcacucua      480

gaggaguugc cugcugcuga gucaccaagu ccuccccaga guccucagga agaguccuuc      540

ucucccacug ccauggaugc caucuuuggg agccuaucug augagggcuc uggcagccaa      600

gaaaaggagg ggccaaguac cucgccugac cugauagacc cugaguccuu uucccaagau      660

auacuacaug acaagauaau ugauuugguu cauuuauugc uccgcaagua ucgagucaag      720

gggcugauca caaaggcaga aaugcugggg agugucauca aaaauuauga ggacuacuuu      780

ccugagauau uuagggaagc cucuguaugc augcaacugc ucuuuggcau ugaugugaag      840

gaaguggacc ccacuagcca cuccuauguc cuugucaccu cccucaaccu cucuuaugau      900

ggcauacagu guaaugagca gagcaugccc aagucuggcc uccugauaau aguccugggu      960

guaaucuuca uggaggggaa cugcaucccu gaagagguua ugugggaagu ccugagcauu     1020

augggggugu augcuggaag ggagcacuuc cucuuugggg agcccaagag gcuccuuacc     1080

caaaauuggg ugcaggaaaa guaccuggug uaccggcagg ugcccggcac ugauccugca     1140

ugcuaugagu uccugugggg uccaagggcc cacgcugaga ccagcaagau gaaaguucuu     1200

gaguacauag ccaaugccaa ugggagggau cccacuucuu acccaucccu guaugaagau     1260

gcuuugagag aggagggaga gggagucuga                                      1290


<210>  2192
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGAB__Homo_sapiens__AAH04479

<400>  2192
auggagaccc aguuccgccg gggcgggcug ggcugcagcc ccgccuccau caagcgcaag       60

aagaagcggg aggacagcgg ggacuucggc cuccaggugu ccaccauguu cagcgaggac      120

gacuuccagu ccacggagcg cgccccguac gggccccagc ugcaguggag ccaggaccug      180

ccccgggucc agguguuccg cgagcaggcg aaccucgagg accggagccc ccgccggacc      240

cagcgcauca ccggcggcga gcagguccug ugggggccga ucacccagau cuuccccacg      300

gugcggcccg ccgaccugac ccgcgugauc augccccucg agcagcgguc ccagcacugc      360

aagccggagg agggccugca ggcccaggag gaggaccugg ggcucguggg cgcccaggcc      420

cugcaggcgg aggagcagga ggccgccuuc uucuccagca cccugaacgu cgggacccuc      480

gaggagcugc ccgccgcgga gucccccagc ccgccgcaga gcccccagga ggaguccuuc      540

ucccccacgg ccauggacgc caucuucggc agccuguccg acgagggcag cgggucccag      600

gagaaggagg gccccagcac cagcccggac cucaucgacc ccgaguccuu cagccaggac      660

auccugcacg acaagaucau cgaccuggug caccuccugc ugcgcaagua ccgggugaag      720

gggcucauca ccaaggccga gaugcugggc uccgucauca agaacuacga ggacuacuuc      780

cccgagaucu uccgcgaggc cagcgugugc augcagcucc uguucggcau cgacgugaag      840

gaggucgacc ccaccuccca cagcuacgug cuggugacgu cccugaaccu cagcuacgac      900

gggauccagu gcaacgagca guccaugccc aagagcggcc ugcugaucau cguccucggg      960

gugaucuuca uggagggcaa cugcaucccc gaggagguga ugugggaggu ccuguccauc     1020

augggggugu acgcgggccg ggagcacuuc cuguucggcg agcccaagcg ccuccugacc     1080

cagaacuggg ugcaggagaa guaccugguc uaccgccagg ugcccgggac cgacccggcc     1140

ugcuacgagu uccucugggg cccccgggcc cacgccgaga ccagcaagau gaaggugcug     1200

gaguacaucg ccaacgcgaa cgggcgggac cccacguccu accccagccu guacgaggac     1260

gcccuccgcg aggagggcga gggggucuga                                      1290


<210>  2193
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGAB__Homo_sapiens__AAH04479

<400>  2193
auggagaccc aguuccgccg cggcggccuc ggcugcuccc ccgccuccau caagcgcaag       60

aagaagcgcg aggacuccgg cgacuucggc cuccaggucu ccaccauguu cuccgaggac      120

gacuuccagu ccaccgagcg cgcccccuac ggcccccagc uccagugguc ccaggaccuc      180

ccccgcgucc aggucuuccg cgagcaggcc aaccucgagg accgcucccc ccgccgcacc      240

cagcgcauca ccggcggcga gcagguccuc uggggcccca ucacccagau cuuccccacc      300

guccgccccg ccgaccucac ccgcgucauc augccccucg agcagcgcuc ccagcacugc      360

aagcccgagg agggccucca ggcccaggag gaggaccucg gccucgucgg cgcccaggcc      420

cuccaggccg aggagcagga ggccgccuuc uucuccucca cccucaacgu cggcacccuc      480

gaggagcucc ccgccgccga gucccccucc cccccccagu ccccccagga ggaguccuuc      540

ucccccaccg ccauggacgc caucuucggc ucccucuccg acgagggcuc cggcucccag      600

gagaaggagg gccccuccac cucccccgac cucaucgacc ccgaguccuu cucccaggac      660

auccuccacg acaagaucau cgaccucguc caccuccucc uccgcaagua ccgcgucaag      720

ggccucauca ccaaggccga gaugcucggc uccgucauca agaacuacga ggacuacuuc      780

cccgagaucu uccgcgaggc cuccgucugc augcagcucc ucuucggcau cgacgucaag      840

gaggucgacc ccaccuccca cuccuacguc cucgucaccu cccucaaccu cuccuacgac      900

ggcauccagu gcaacgagca guccaugccc aaguccggcc uccucaucau cguccucggc      960

gucaucuuca uggagggcaa cugcaucccc gaggagguca ugugggaggu ccucuccauc     1020

augggcgucu acgccggccg cgagcacuuc cucuucggcg agcccaagcg ccuccucacc     1080

cagaacuggg uccaggagaa guaccucguc uaccgccagg uccccggcac cgaccccgcc     1140

ugcuacgagu uccucugggg cccccgcgcc cacgccgaga ccuccaagau gaagguccuc     1200

gaguacaucg ccaacgccaa cggccgcgac cccaccuccu accccucccu cuacgaggac     1260

gcccuccgcg aggagggcga gggcgucuga                                      1290


<210>  2194
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGAB__Homo_sapiens__AAH04479

<400>  2194
auggagaccc aguucagaag gggcgggcug ggaugcagcc ccgccuccau caagcggaaa       60

aagaaacgcg aagacucugg ugauuuuggc cuccaagugu caacaauguu cagugaggac      120

gauuuucaga gcacugaacg agcuccuuac gggccacagc uucagugguc ccaagaccug      180

ccgcgugucc agguuuucag agagcaggca aacuuggaag auaggucucc ccggcgcacg      240

cagagaauua ccggaggcga gcaaguguua ugggguccua uaacacagau cuuuccaacu      300

guaaggcccg ccgaccugac ccgggugauu augccucuag agcagcgcuc gcagcacugu      360

aagccagaag aggggcucca agcgcaggaa gaggaucugg gacuugucgg cgcucaggcc      420

cugcaagcag aggaacagga ggccgcuuuc uuuucaagca cauugaaugu gggcacccuc      480

gaggaacugc ccgcagccga aaguccuucc ccaccgcagu cuccccagga ggagagcuuc      540

uccccuacug cuauggacgc caucuuuggg ucacugagug augaaggaag cgguucucaa      600

gagaaagaag gcccauccac aucacccgac cucauugauc cugagagcuu cagucaggac      660

aucuuacaug auaagauaau cgaccugguu caccuuuugc ugcgaaagua uagagugaaa      720

gggcuaauua ccaaggcgga aaugcucgga ucugucauca aaaacuacga ggacuauuuu      780

ccagagauuu ucagggaagc auccgugugc augcagcugc uuuuuggcau cgauguaaag      840

gagguugacc ccacgagcca uucguacgug cuggucacuu cuuugaaucu cuccuaugau      900

gguauacagu guaacgaaca aucaaugccg aaaagugggc uguuaauuau cgugcuggga      960

gugauuuuca uggagggcaa uugcaucccu gaagagguca ugugggaggu ucucagcauc     1020

augggcgugu acgccgggcg ggaacacuuc cuuuuuggag agcccaagcg ucuguugacc     1080

cagaacuggg uacaggaaaa guaucuagug uaccgccagg ucccagguac agacccugcu     1140

uguuacgagu uccugugggg ccccagagcc caugcagaga cuuccaaaau gaaggugcuc     1200

gaauauauug cuaaugccaa cgggagggau ccaaccucuu accccagccu guaugaggac     1260

gcgcuucggg aagagggaga aggcguuuga                                      1290


<210>  2195
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGAB__Homo_sapiens__AAH04479

<400>  2195
auggagaccc aguucagaag aggcggccug ggcugcagcc ccgccagcau caagagaaag       60

aagaagagag aggacagcgg cgacuucggc cugcagguga gcaccauguu cagcgaggac      120

gacuuccaga gcaccgagag agcccccuac ggcccccagc ugcaguggag ccaggaccug      180

cccagagugc agguguucag agagcaggcc aaccuggagg acagaagccc cagaagaacc      240

cagagaauca ccggcggcga gcaggugcug uggggcccca ucacccagau cuuccccacc      300

gugagacccg ccgaccugac cagagugauc augccccugg agcagagaag ccagcacugc      360

aagcccgagg agggccugca ggcccaggag gaggaccugg gccugguggg cgcccaggcc      420

cugcaggccg aggagcagga ggccgccuuc uucagcagca cccugaacgu gggcacccug      480

gaggagcugc ccgccgccga gagccccagc cccccccaga gcccccagga ggagagcuuc      540

agccccaccg ccauggacgc caucuucggc agccugagcg acgagggcag cggcagccag      600

gagaaggagg gccccagcac cagccccgac cugaucgacc ccgagagcuu cagccaggac      660

auccugcacg acaagaucau cgaccuggug caccugcugc ugagaaagua cagagugaag      720

ggccugauca ccaaggccga gaugcugggc agcgugauca agaacuacga ggacuacuuc      780

cccgagaucu ucagagaggc cagcgugugc augcagcugc uguucggcau cgacgugaag      840

gagguggacc ccaccagcca cagcuacgug cuggugacca gccugaaccu gagcuacgac      900

ggcauccagu gcaacgagca gagcaugccc aagagcggcc ugcugaucau cgugcugggc      960

gugaucuuca uggagggcaa cugcaucccc gaggagguga ugugggaggu gcugagcauc     1020

augggcgugu acgccggcag agagcacuuc cuguucggcg agcccaagag acugcugacc     1080

cagaacuggg ugcaggagaa guaccuggug uacagacagg ugcccggcac cgaccccgcc     1140

ugcuacgagu uccugugggg ccccagagcc cacgccgaga ccagcaagau gaaggugcug     1200

gaguacaucg ccaacgccaa cggcagagac cccaccagcu accccagccu guacgaggac     1260

gcccugagag aggagggcga gggcguguga                                      1290


<210>  2196
<211>  1290
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGAB__Homo_sapiens__AAH04479

<400>  2196
auggagaccc aguucagacg gggcgggcug ggaugcagcc ccgccuccau caagcgcaaa       60

aagaaaagag aagacucugg cgauuuuggg cuccaaguga gcacaauguu cuccgaggac      120

gauuuucagu cuacggaacg ggcuccuuac ggaccgcagc ugcaguggag ccaagaccuu      180

ccccgcgucc agguuuucag agagcaggcc aaccuggaag aucggucccc ucgcagaacc      240

cagcggauua caggcgggga gcaagugcuc uggggaccca ucacccagau uuuuccuaca      300

gugcgccccg cggaccugac cagagucauc augccucuug agcagcgguc ucagcacugu      360

aagccggaag agggccugca agcucaggaa gaggaucucg gccugguggg ggcccaggcc      420

cugcaagcug aggaacagga ggccgcuuuc uuuagcucca cacucaaugu uggaacccug      480

gaggaacuuc ccgccgcgga aagcccuucu cccccucaga gcccccagga ggaguccuuc      540

ucuccgacgg ccauggacgc uauuuuuggc ucccugagcg augaaggguc uggaucccaa      600

gagaaagaag gcccuagcac cucccccgac cucaucgauc cugagucuuu cagccaggac      660

auccugcaug auaagauuau cgaccuugug caucugcucc ugcgcaagua uagagucaaa      720

gggcugauua caaaggccga aaugcucgga uccgugauca aaaacuacga ggacuauuuu      780

cccgagauuu uccgggaagc uagcguuugc augcagcugc uuuuuggcau cgaugugaag      840

gaggucgacc ccaccucuca cuccuacgug cuggugacaa gccucaaucu gucuuaugau      900

ggcauucagu guaacgaaca aagcaugccu aaauccgggc uucugaucau cguccucgga      960

guuauuuuca uggagggcaa uugcaucccg gaagagguga ugugggaggu gcugucuauu     1020

augggggucu acgccggacg cgaacacuuc cuguuuggcg agcccaagag acuccugacc     1080

cagaacuggg ugcaggaaaa guaucuuguu uacagacagg ugccugggac ggaccccgcg     1140

uguuacgagu uccugugggg accucgggcc caugcugaga caagcaaaau gaagguccuc     1200

gaauauaucg ccaaugcuaa cggccgcgau cccaccuccu acccgagccu guaugaggac     1260

gcccuucggg aagagggcga agggguguga                                      1290


<210>  2197
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A10__Homo_sapiens__A0A024RC14

<400>  2197

Met Pro Arg Ala Pro Lys Arg Gln Arg Cys Met Pro Glu Glu Asp Leu 
1               5                   10                  15      


Gln Ser Gln Ser Glu Thr Gln Gly Leu Glu Gly Ala Gln Ala Pro Leu 
            20                  25                  30          


Ala Val Glu Glu Asp Ala Ser Ser Ser Thr Ser Thr Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys Tyr 
    50                  55                  60                  


Pro Leu Ile Pro Ser Thr Pro Glu Glu Val Ser Ala Asp Asp Glu Thr 
65                  70                  75                  80  


Pro Asn Pro Pro Gln Ser Ala Gln Ile Ala Cys Ser Ser Pro Ser Val 
                85                  90                  95      


Val Ala Ser Leu Pro Leu Asp Gln Ser Asp Glu Gly Ser Ser Ser Gln 
            100                 105                 110         


Lys Glu Glu Ser Pro Ser Thr Leu Gln Val Leu Pro Asp Ser Glu Ser 
        115                 120                 125             


Leu Pro Arg Ser Glu Ile Asp Glu Lys Val Thr Asp Leu Val Gln Phe 
    130                 135                 140                 


Leu Leu Phe Lys Tyr Gln Met Lys Glu Pro Ile Thr Lys Ala Glu Ile 
145                 150                 155                 160 


Leu Glu Ser Val Ile Lys Asn Tyr Glu Asp His Phe Pro Leu Leu Phe 
                165                 170                 175     


Ser Glu Ala Ser Glu Cys Met Leu Leu Val Phe Gly Ile Asp Val Lys 
            180                 185                 190         


Glu Val Asp Pro Thr Gly His Ser Phe Val Leu Val Thr Ser Leu Gly 
        195                 200                 205             


Leu Thr Tyr Asp Gly Met Leu Ser Asp Val Gln Ser Met Pro Lys Thr 
    210                 215                 220                 


Gly Ile Leu Ile Leu Ile Leu Ser Ile Ile Phe Ile Glu Gly Tyr Cys 
225                 230                 235                 240 


Thr Pro Glu Glu Val Ile Trp Glu Ala Leu Asn Met Met Gly Leu Tyr 
                245                 250                 255     


Asp Gly Met Glu His Leu Ile Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
            260                 265                 270         


Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu Tyr Arg Gln Val Pro Gly 
        275                 280                 285             


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala His Ala 
    290                 295                 300                 


Glu Ile Arg Lys Met Ser Leu Leu Lys Phe Leu Ala Lys Val Asn Gly 
305                 310                 315                 320 


Ser Asp Pro Arg Ser Phe Pro Leu Trp Tyr Glu Glu Ala Leu Lys Asp 
                325                 330                 335     


Glu Glu Glu Arg Ala Gln Asp Arg Ile Ala Thr Thr Asp Asp Thr Thr 
            340                 345                 350         


Ala Met Ala Ser Ala Ser Ser Ser Ala Thr Gly Ser Phe Ser Tyr Pro 
        355                 360                 365             


Glu 
    


<210>  2198
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A10__Homo_sapiens__EAW99421

<400>  2198
augccucgag cuccaaagcg ucagcgcugc augccugaag aagaucuuca aucccaaagu       60

gagacacagg gccucgaggg ugcacaggcu ccccuggcug uggaggagga ugcuucauca      120

uccacuucca ccagcuccuc uuuuccaucc ucuuuucccu ccuccuccuc uuccuccucc      180

uccuccugcu auccucuaau accaagcacc ccagaggagg uuucugcuga ugaugagaca      240

ccaaauccuc cccagagugc ucagauagcc ugcuccuccc ccucggucgu ugcuucccuu      300

ccauuagauc aaucugauga gggcuccagc agccaaaagg aggagagucc aagcacccua      360

cagguccugc cagacaguga gucuuuaccc agaagugaga uagaugaaaa ggugacugau      420

uuggugcagu uucugcucuu caaguaucaa augaaggagc cgaucacaaa ggcagaaaua      480

cuggagagug ucauaaaaaa uuaugaagac cacuucccuu uguuguuuag ugaagccucc      540

gagugcaugc ugcuggucuu uggcauugau guaaaggaag uggaucccac uggccacucc      600

uuuguccuug ucaccucccu gggccucacc uaugauggga ugcugaguga uguccagagc      660

augcccaaga cuggcauucu cauacuuauc cuaagcauaa ucuucauaga gggcuacugc      720

accccugagg aggucaucug ggaagcacug aauaugaugg ggcuguauga ugggauggag      780

caccucauuu auggggagcc caggaagcug cucacccaag auugggugca ggaaaacuac      840

cuggaguacc ggcaggugcc uggcagugau ccugcacggu augaguuucu guggggucca      900

agggcucaug cugaaauuag gaagaugagu cuccugaaau uuuuggccaa gguaaauggg      960

agugauccaa gauccuuccc acugugguau gaggaggcuu ugaaagauga ggaagagaga     1020

gcccaggaca gaauugccac cacagaugau acuacugcca uggccagugc aaguucuagc     1080

gcuacaggua gcuucuccua cccugaauaa                                      1110


<210>  2199
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A10__Homo_sapiens__EAW99421

<400>  2199
augccccgcg ccccgaagcg gcagcgcugc augcccgagg aggaccugca gagccagucc       60

gagacccagg gccucgaggg ggcccaggcg ccccuggccg uggaggagga cgccagcucc      120

agcaccucca cgagcuccag cuuccccucc agcuucccgu ccagcuccag cuccagcucc      180

agcuccugcu acccccugau ccccagcacc cccgaggagg ucagcgccga cgacgagacc      240

ccgaacccgc cccaguccgc ccagaucgcg ugcagcuccc ccagcguggu ggccucccuc      300

ccccuggacc agagcgacga gggcuccagc ucccagaagg aggagagccc cuccacccug      360

cagguccucc ccgacagcga gucccugccc cggagcgaga ucgacgagaa ggugacggac      420

cuggugcagu uccuccuguu caaguaccag augaaggagc cgaucaccaa ggccgagauc      480

cuggaguccg ucaucaagaa cuacgaggac cacuuccccc uccuguucag cgaggccucc      540

gagugcaugc ugcucguguu cgggaucgac gugaaggagg ucgaccccac cggccacagc      600

uucgugcugg ugaccucccu ggggcucacg uacgacggca ugcugagcga cguccagagc      660

augcccaaga ccggcauccu gauccucauc cuguccauca ucuucaucga gggguacugc      720

accccggagg aggugaucug ggaggcgcug aacaugaugg gccucuacga cgggauggag      780

caccugaucu acggcgagcc ccgcaagcug cucacccagg acugggugca ggagaacuac      840

cuggaguacc ggcagguccc cgggagcgac cccgcccgcu acgaguuccu guggggcccg      900

cgggcccacg ccgagauccg caagaugucc cuccugaagu uccuggccaa ggugaacggc      960

agcgaccccc gguccuuccc ccucugguac gaggaggcgc ugaaggacga ggaggagcgc     1020

gcccaggacc ggaucgccac gaccgacgac accaccgcca uggccagcgc guccagcucc     1080

gccacgggga gcuucuccua ccccgaguga                                      1110


<210>  2200
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A10__Homo_sapiens__EAW99421

<400>  2200
augccccgcg cccccaagcg ccagcgcugc augcccgagg aggaccucca gucccagucc       60

gagacccagg gccucgaggg cgcccaggcc ccccucgccg ucgaggagga cgccuccucc      120

uccaccucca ccuccuccuc cuuccccucc uccuuccccu ccuccuccuc cuccuccucc      180

uccuccugcu acccccucau ccccuccacc cccgaggagg ucuccgccga cgacgagacc      240

cccaaccccc cccaguccgc ccagaucgcc ugcuccuccc ccuccgucgu cgccucccuc      300

ccccucgacc aguccgacga gggcuccucc ucccagaagg aggagucccc cuccacccuc      360

cagguccucc ccgacuccga gucccucccc cgcuccgaga ucgacgagaa ggucaccgac      420

cucguccagu uccuccucuu caaguaccag augaaggagc ccaucaccaa ggccgagauc      480

cucgaguccg ucaucaagaa cuacgaggac cacuuccccc uccucuucuc cgaggccucc      540

gagugcaugc uccucgucuu cggcaucgac gucaaggagg ucgaccccac cggccacucc      600

uucguccucg ucaccucccu cggccucacc uacgacggca ugcucuccga cguccagucc      660

augcccaaga ccggcauccu cauccucauc cucuccauca ucuucaucga gggcuacugc      720

acccccgagg aggucaucug ggaggcccuc aacaugaugg gccucuacga cggcauggag      780

caccucaucu acggcgagcc ccgcaagcuc cucacccagg acugggucca ggagaacuac      840

cucgaguacc gccagguccc cggcuccgac cccgcccgcu acgaguuccu cuggggcccc      900

cgcgcccacg ccgagauccg caagaugucc cuccucaagu uccucgccaa ggucaacggc      960

uccgaccccc gcuccuuccc ccucugguac gaggaggccc ucaaggacga ggaggagcgc     1020

gcccaggacc gcaucgccac caccgacgac accaccgcca uggccuccgc cuccuccucc     1080

gccaccggcu ccuucuccua ccccgaguga                                      1110


<210>  2201
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A10__Homo_sapiens__EAW99421

<400>  2201
augcccagag ccccuaagag gcagcggugc augccagagg aagaccugca aagccagucc       60

gagacccagg gccucgaagg ggcucaggca ccgcuugccg uggaggaaga ugcgucuuca      120

aguacaagca cuuccucuuc guuccccagc ucauuuccua guuccucuag cuccucaagu      180

agcucuuguu acccacugau ccccuccacg ccugaggagg ucucagcuga cgaugaaacc      240

ccaaaucccc cucaaagcgc ccagauugca ugcaguucuc cauccguugu ggccagcuug      300

ccguuagacc agucggauga gggaucuucc ucacagaaag aagagagucc cagcacacug      360

caaguacuac cugacuccga gucucuccca cgcagcgaaa uagaugagaa ggugacugac      420

cugguccagu uccuucuguu uaaauaucag augaaggaac ccaucaccaa agcugagauu      480

uuggaaucag ugaucaagaa cuacgaggau cacuucccuc uccuguuuag ugaggcaucc      540

gaauguaugc ugcucguuuu cgguauugac gugaaggagg ucgauccaac aggccauagc      600

uuuguguuag uaaccucucu ggggcuuacu uaugacggaa uguugucaga uguucagagu      660

augcccaaaa caggcauccu gauacuaauc cucagcauua ucuucauuga agguuacugc      720

accccggagg aagugaucug ggaggcccug aacaugaugg ggcuuuauga cggaauggag      780

caccugauau acggcgaacc ucgaaaguug cucacgcaag acugggucca ggagaauuau      840

cuggaauacc gucaggugcc cggcuccgau ccagcuagau acgaguuuuu augggggccu      900

agggcccaug cggaaauucg gaaaaugucu cugcucaagu uccuugcaaa agugaacgga      960

ucggaccccc gcagcuuucc acugugguau gaggaggccu ugaaggauga agaggaaaga     1020

gcucaagaca ggaucgccac uaccgaugac acaacugcaa uggcuuccgc cucaaguucu     1080

gcgaccggua gcuucuccua ccccgaguga                                      1110


<210>  2202
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A10__Homo_sapiens__EAW99421

<400>  2202
augcccagag cccccaagag acagagaugc augcccgagg aggaccugca gagccagagc       60

gagacccagg gccuggaggg cgcccaggcc ccccuggccg uggaggagga cgccagcagc      120

agcaccagca ccagcagcag cuuccccagc agcuucccca gcagcagcag cagcagcagc      180

agcagcugcu acccccugau ccccagcacc cccgaggagg ugagcgccga cgacgagacc      240

cccaaccccc cccagagcgc ccagaucgcc ugcagcagcc ccagcguggu ggccagccug      300

ccccuggacc agagcgacga gggcagcagc agccagaagg aggagagccc cagcacccug      360

caggugcugc ccgacagcga gagccugccc agaagcgaga ucgacgagaa ggugaccgac      420

cuggugcagu uccugcuguu caaguaccag augaaggagc ccaucaccaa ggccgagauc      480

cuggagagcg ugaucaagaa cuacgaggac cacuuccccc ugcuguucag cgaggccagc      540

gagugcaugc ugcugguguu cggcaucgac gugaaggagg uggaccccac cggccacagc      600

uucgugcugg ugaccagccu gggccugacc uacgacggca ugcugagcga cgugcagagc      660

augcccaaga ccggcauccu gauccugauc cugagcauca ucuucaucga gggcuacugc      720

acccccgagg aggugaucug ggaggcccug aacaugaugg gccuguacga cggcauggag      780

caccugaucu acggcgagcc cagaaagcug cugacccagg acugggugca ggagaacuac      840

cuggaguaca gacaggugcc cggcagcgac cccgccagau acgaguuccu guggggcccc      900

agagcccacg ccgagaucag aaagaugagc cugcugaagu uccuggccaa ggugaacggc      960

agcgacccca gaagcuuccc ccugugguac gaggaggccc ugaaggacga ggaggagaga     1020

gcccaggaca gaaucgccac caccgacgac accaccgcca uggccagcgc cagcagcagc     1080

gccaccggca gcuucagcua ccccgaguga                                      1110


<210>  2203
<211>  1110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A10__Homo_sapiens__EAW99421

<400>  2203
augcccagag ccccuaagcg gcagcgcugc augccggagg aagaccugca aagccagucc       60

gagacccagg gacucgaagg ggcucaggcg ccccuggccg uggaggaaga ugcuucuagc      120

uccacaucua cgagcuccuc uuucccuagc uccuuuccca gcagcuccuc uucuuccucc      180

ucuuccuguu acccucuuau ccccagcacc ccugaggagg ucuccgccga cgaugaaaca      240

ccgaaucccc cucaaucugc ccagauugcu ugcagcuccc ccagcguugu ggccucucug      300

ccucucgacc aguccgauga gggaagcucu agccagaaag aagagucccc cucuacccug      360

caagugcuuc cggacagcga gucccugccu agaagcgaaa ucgaugagaa ggucacagac      420

cucgugcagu uccugcuguu uaaauaucag augaaggaac ccauuaccaa agcugagauc      480

cucgaaucug uuauuaagaa cuacgaggau cacuucccuc ugcuuuuuag cgaggccagc      540

gaauguaugc ugcucguguu cggcaucgac gucaaggagg uggaucccac agggcauucu      600

uuuguucugg ugaccucccu uggacugacg uaugacggca ugcucagcga uguccagucc      660

augcccaaaa ccgggauccu gauucugauc cucucuauua ucuucauuga aggauacugc      720

acaccugagg aagugaucug ggaggcgcug aacaugaugg gccuuuauga cggcauggag      780

caccugauuu acggggaacc gcggaagcuc cugacccaag acugggugca ggagaauuau      840

cuugaauacc gccagguccc cggaagcgau ccugccagau acgaguuucu guggggcccc      900

cgggcucaug ccgaaauccg caaaaugucc cuccugaagu uccuggcuaa aguuaacggg      960

ucugacccuc ggagcuuucc ccucugguau gaggaggccc ugaaggauga agaggaaaga     1020

gcgcaagacc gcaucgccac aaccgaugac acgacagcua uggccuccgc uucuagcucc     1080

gccaccggca gcuucucuua cccggaguga                                      1110


<210>  2204
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A12__Homo_sapiens__P43365

<400>  2204

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Gln Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Arg Glu Val Pro Ala Ala Glu Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Thr Leu Pro Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Asp Glu Gly Ser Ser Asn Glu Glu Gln Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Thr Ser Phe Gln Val Ala Leu Ser Arg Lys 
            100                 105                 110         


Met Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg Asn Phe Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Arg Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Val Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Ala Ser Asp Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Thr Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Leu Leu Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Ala Phe Arg Glu Gly Glu Glu 
305                 310                 


<210>  2205
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A12__Homo_sapiens__AAH03408

<400>  2205
augccacuug agcagaggag ucagcacugc aagccugagg aaggccuuga ggcccaagga       60

gaggcccugg gcuugguggg ugcgcaggcu ccugcuacug aggagcagga gacugccucc      120

uccuccucua cucuagugga agucacccug cgggaggugc cugcugccga gucaccaagu      180

ccuccccaca guccucaggg agccuccacc cuccccacua ccaucaacua uacucucugg      240

agucaauccg augagggcuc cagcaacgaa gaacaggaag ggccaagcac cuuuccugac      300

cuggagacga gcuuccaagu agcacucagu aggaagaugg cugaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccauuc acaaaggcag aaaugcuggg gagugucauc      420

agaaauuucc aggacuucuu uccugugauc uucagcaaag ccuccgagua cuugcagcug      480

gucuuuggca ucgagguggu ggaagugguc cgcaucggcc acuuguacau ccuugucacc      540

ugccugggcc ucuccuacga uggccugcug ggcgacaauc agaucgugcc caagacaggc      600

cuccugauaa ucguccuggc cauaaucgca aaagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugagugu guuggaggca ucugauggga gggaggacag ugucuuugcg      720

caucccagga agcugcucac ccaagauuug gugcaggaaa acuaccugga guaccggcag      780

guccccggca gugauccugc augcuacgag uuccuguggg guccaagggc ccucguugaa      840

accagcuaug ugaaaguccu gcaccauuug cuaaagauca guggaggacc ucacauuucc      900

uacccacccc ugcaugaaug ggcuuuuaga gagggggaag aguga                      945


<210>  2206
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A12__Homo_sapiens__AAH03408

<400>  2206
augccccugg agcagcgcag ccagcacugc aagccggagg agggccucga ggcccagggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagga gaccgccucc      120

agcuccagca cgcucgucga ggugacccug cgggaggugc ccgccgcgga gucccccagc      180

ccgccccaca gcccccaggg cgccuccacc cugcccacca cgaucaacua cacccucugg      240

ucccagagcg acgagggguc cagcaacgag gagcaggagg gcccguccac cuuccccgac      300

cuggagacca gcuuccaggu cgcccugucc cgcaagaugg ccgagcucgu gcacuuccug      360

cugcucaagu accgggcgcg cgagcccuuc acgaaggccg agaugcuggg cagcgugauc      420

cggaacuucc aggacuucuu ccccgucauc uucuccaagg ccagcgagua ccugcagcuc      480

guguucggga ucgagguggu cgagguggug cgcaucggcc accuguacau ccuggugacc      540

ugccucgggc uguccuacga cggccugcuc ggggacaacc agaucguccc gaagaccggc      600

cugcugauca ucgugcucgc caucaucgcc aaggagggcg acugcgcgcc cgaggagaag      660

aucugggagg agcugagcgu ccuggaggcc agcgacgggc gggaggacuc cguguucgcc      720

cacccccgca agcuccugac ccaggaccug gugcaggaga acuaccucga guaccggcag      780

guccccggca gcgacccggc cugcuacgag uuccuguggg ggccccgcgc ccugguggag      840

acguccuacg ugaagguccu ccaccaccuc cugaagauca gcggcggccc ccacaucucc      900

uacccgcccc ugcacgagug ggcguuccgg gagggggagg aguga                      945


<210>  2207
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A12__Homo_sapiens__AAH03408

<400>  2207
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccagggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagga gaccgccucc      120

uccuccucca cccucgucga ggucacccuc cgcgaggucc ccgccgccga gucccccucc      180

cccccccacu ccccccaggg cgccuccacc cuccccacca ccaucaacua cacccucugg      240

ucccaguccg acgagggcuc cuccaacgag gagcaggagg gccccuccac cuuccccgac      300

cucgagaccu ccuuccaggu cgcccucucc cgcaagaugg ccgagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccuuc accaaggccg agaugcucgg cuccgucauc      420

cgcaacuucc aggacuucuu ccccgucauc uucuccaagg ccuccgagua ccuccagcuc      480

gucuucggca ucgaggucgu cgaggucguc cgcaucggcc accucuacau ccucgucacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc agaucguccc caagaccggc      600

cuccucauca ucguccucgc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccgu ccucgaggcc uccgacggcc gcgaggacuc cgucuucgcc      720

cacccccgca agcuccucac ccaggaccuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucgucgag      840

accuccuacg ucaagguccu ccaccaccuc cucaagaucu ccggcggccc ccacaucucc      900

uacccccccc uccacgagug ggccuuccgc gagggcgagg aguga                      945


<210>  2208
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A12__Homo_sapiens__AAH03408

<400>  2208
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccagggg       60

gaggcucuug gacugguggg ugcacaggcc ccagcgaccg aagaacagga gacagcuucc      120

ucuucaagua cuuuggucga aguuacguua agggaggugc cggccgcaga aagccccucc      180

ccuccacauu cuccccaagg cgccucgacc cugccuacaa cuaucaacua cacccuaugg      240

ucacagagcg acgaggggag uuccaaugag gaacaggagg gaccaucuac auuccccgau      300

cucgaaacca gcuuucaggu agcucugucc cggaaaaugg cagagcuugu gcacuuccug      360

uugcucaagu accgcgcccg agaaccuuuu acuaaagcug agaugcuggg cucagucauu      420

cguaacuucc aagacuuuuu cccagugaua uuuaguaagg ccagcgagua ccugcagcuc      480

guuuucggua ucgaaguggu cgagguggua agaauugggc auuuauauau ccugguuaca      540

ugucuuggau ugucuuacga uggccugcua ggcgacaauc agauugugcc gaaaaccggg      600

cuccugauca uaguccuugc gaucauugca aaggaaggag auugcgcccc cgaggaaaag      660

aucugggagg agcuguccgu guuggaggcu ucagacggua gggaggauag cguguuugcc      720

cacccucgga aacuccugac gcaggacuua guccaagaaa acuaucugga guaccgccag      780

guuccaggca gugaucccgc auguuaugag uuccucuggg ggccuagagc ucuuguggaa      840

acuucuuacg uaaaggugcu gcaucacuug cuaaaaauuu ccggaggccc acacaucagc      900

uaucccccgc ugcaugagug ggccuuuagg gaaggugagg aauga                      945


<210>  2209
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A12__Homo_sapiens__AAH03408

<400>  2209
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggcccagggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagga gaccgccagc      120

agcagcagca cccuggugga ggugacccug agagaggugc ccgccgccga gagccccagc      180

cccccccaca gcccccaggg cgccagcacc cugcccacca ccaucaacua cacccugugg      240

agccagagcg acgagggcag cagcaacgag gagcaggagg gccccagcac cuuccccgac      300

cuggagacca gcuuccaggu ggcccugagc agaaagaugg ccgagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccuuc accaaggccg agaugcuggg cagcgugauc      420

agaaacuucc aggacuucuu ccccgugauc uucagcaagg ccagcgagua ccugcagcug      480

guguucggca ucgagguggu ggagguggug agaaucggcc accuguacau ccuggugacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc agaucgugcc caagaccggc      600

cugcugauca ucgugcuggc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu gcuggaggcc agcgacggca gagaggacag cguguucgcc      720

caccccagaa agcugcugac ccaggaccug gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugguggag      840

accagcuacg ugaaggugcu gcaccaccug cugaagauca gcggcggccc ccacaucagc      900

uacccccccc ugcacgagug ggccuucaga gagggcgagg aguga                      945


<210>  2210
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A12__Homo_sapiens__AAH03408

<400>  2210
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccagggg       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aagaacagga gacagccucc      120

ucuagcucca cgcuggucga aguuacccuc cgggaggugc ccgccgcuga aucuccuagc      180

ccuccccauu cuccccaagg ggccuccaca cugccuacca caaucaacua cacccuuugg      240

agccaguccg acgagggaag cucuaaugag gaacaggagg gcccguccac auuccccgau      300

cuggaaacca gcuuucaggu ggcucucucu cgcaaaaugg ccgagcuggu ccacuuccug      360

cuccugaagu acagagcgcg ggaaccuuuu acgaaagccg agaugcuugg guccgugauu      420

cgcaacuucc aagacuuuuu ccccguuauc uuuagcaagg cuucugagua ccugcagcuc      480

guguucggaa uugaagucgu ggagguugug agaaucggcc aucuguauau ucuugucacc      540

ugucugggcc ucuccuacga ugggcugcug ggagacaauc agaucgugcc uaaaacaggc      600

cuccugauca uugugcuugc caucauugcu aaggaagggg auugcgcccc cgaggaaaag      660

aucugggagg agcugagcgu ccucgaagcg uccgacggac gggaggauuc uguuuuugcc      720

cacccgcgca aacugcuuac ccaggaccug gugcaagaaa acuaucucga guacagacag      780

gugccuggca gcgaucccgc uuguuaugag uuccuguggg ggccucgggc ccuggucgag      840

acauccuacg ugaagguucu ccaucaucug cuuaaaauua gcggaggccc ccacaucucu      900

uaucccccuc ugcacgagug ggcuuuucgc gaaggcgagg aauga                      945


<210>  2211
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A1__Homo_sapiens__P43355

<400>  2211

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  2212
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A1__Homo_sapiens__AAA03229

<400>  2212
augucucuug agcagaggag ucugcacugc aagccugagg aagcccuuga ggcccaacaa       60

gaggcccugg gccuggugug ugugcaggcu gccaccuccu ccuccucucc ucugguccug      120

ggcacccugg aggaggugcc cacugcuggg ucaacagauc cuccccagag uccucaggga      180

gccuccgccu uucccacuac caucaacuuc acucgacaga ggcaacccag ugaggguucc      240

agcagccgug aagaggaggg gccaagcacc ucuuguaucc uggaguccuu guuccgagca      300

guaaucacua agaagguggc ugauuugguu gguuuucugc uccucaaaua ucgagccagg      360

gagccaguca caaaggcaga aaugcuggag agugucauca aaaauuacaa gcacuguuuu      420

ccugagaucu ucggcaaagc cucugagucc uugcagcugg ucuuuggcau ugacgugaag      480

gaagcagacc ccaccggcca cuccuauguc cuugucaccu gccuaggucu cuccuaugau      540

ggccugcugg gugauaauca gaucaugccc aagacaggcu uccugauaau uguccugguc      600

augauugcaa uggagggcgg ccaugcuccu gaggaggaaa ucugggagga gcugagugug      660

auggaggugu augaugggag ggagcacagu gccuaugggg agcccaggaa gcugcucacc      720

caagauuugg ugcaggaaaa guaccuggag uaccggcagg ugccggacag ugaucccgca      780

cgcuaugagu uccugugggg uccaagggcc cucgcugaaa ccagcuaugu gaaaguccuu      840

gaguauguga ucaaggucag ugcaagaguu cgcuuuuucu ucccaucccu gcgugaagca      900

gcuuugagag aggaggaaga gggagucuga                                       930


<210>  2213
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A1__Homo_sapiens__AAA03229

<400>  2213
augagccugg agcagcgcuc ccuccacugc aagcccgagg aggcccugga ggcccagcag       60

gaggcgcugg gccucgugug cguccaggcc gccaccagcu ccagcucccc gcuggugcug      120

gggacccucg aggaggugcc cacggccggc agcaccgacc cgccccaguc cccgcagggg      180

gccagcgcgu uccccaccac caucaacuuc acgcggcagc gccagcccuc cgagggcagc      240

uccagccggg aggaggaggg gcccuccacc agcugcaucc uggagucccu guuccgcgcc      300

gucaucacca agaagguggc cgaccucgug ggcuuccugc ugcucaagua ccgggcccgc      360

gagcccguca ccaaggcgga gaugcuggag agcgugauca agaacuacaa gcacugcuuc      420

cccgagaucu ucggcaaggc cuccgagagc cugcagcucg uguucgggau cgacgucaag      480

gaggccgacc ccacgggcca cuccuacgug cuggugaccu gccuggggcu cagcuacgac      540

ggccugcugg gggacaacca gaucaugccc aagaccggcu uccucaucau cguccuggug      600

augaucgcca uggagggcgg gcacgccccg gaggaggaga ucugggagga gcugagcgug      660

auggaggucu acgacggccg ggagcacucc gcguacgggg agccccgcaa gcuccugacc      720

caggaccugg ugcaggagaa guaccucgag uaccgccagg ugcccgacag cgaccccgcc      780

cgguacgagu uccugugggg cccgcgggcc cuggccgaga cguccuacgu caaggugcuc      840

gaguacguga ucaaggucag cgcccgcgug cgguucuucu uccccucccu gcgcgaggcg      900

gcccugcggg aggaggagga gggcguguga                                       930


<210>  2214
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A1__Homo_sapiens__AAA03229

<400>  2214
augucccucg agcagcgcuc ccuccacugc aagcccgagg aggcccucga ggcccagcag       60

gaggcccucg gccucgucug cguccaggcc gccaccuccu ccuccucccc ccucguccuc      120

ggcacccucg aggagguccc caccgccggc uccaccgacc ccccccaguc cccccagggc      180

gccuccgccu uccccaccac caucaacuuc acccgccagc gccagcccuc cgagggcucc      240

uccucccgcg aggaggaggg ccccuccacc uccugcaucc ucgagucccu cuuccgcgcc      300

gucaucacca agaaggucgc cgaccucguc ggcuuccucc uccucaagua ccgcgcccgc      360

gagcccguca ccaaggccga gaugcucgag uccgucauca agaacuacaa gcacugcuuc      420

cccgagaucu ucggcaaggc cuccgagucc cuccagcucg ucuucggcau cgacgucaag      480

gaggccgacc ccaccggcca cuccuacguc cucgucaccu gccucggccu cuccuacgac      540

ggccuccucg gcgacaacca gaucaugccc aagaccggcu uccucaucau cguccucguc      600

augaucgcca uggagggcgg ccacgccccc gaggaggaga ucugggagga gcucuccguc      660

auggaggucu acgacggccg cgagcacucc gccuacggcg agccccgcaa gcuccucacc      720

caggaccucg uccaggagaa guaccucgag uaccgccagg uccccgacuc cgaccccgcc      780

cgcuacgagu uccucugggg cccccgcgcc cucgccgaga ccuccuacgu caagguccuc      840

gaguacguca ucaaggucuc cgcccgcguc cgcuucuucu uccccucccu ccgcgaggcc      900

gcccuccgcg aggaggagga gggcgucuga                                       930


<210>  2215
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A1__Homo_sapiens__AAA03229

<400>  2215
augagccugg agcagagauc ccuccacugc aagcccgaag aggcccuuga agcucaacag       60

gaggcacugg gcuuggugug uguccaggcc gcgaccucuu caaguagccc uuuaguucug      120

gggacacuag aagaggugcc aacugcugga uccacggacc cgccccaguc uccucaaggu      180

gccucggcau ucccaaccac aaucaacuuu acuaggcagc ggcagcccuc agagggcagc      240

aguucccgcg aagaggaagg gccuucuacc agcugcauuc ucgagucccu guuccgagcc      300

guaauaacca aaaagguggc ugaucuuguc ggauuucugu ugcucaaaua ccgugcaaga      360

gagccaguga caaaggccga aaugcuggag ucaguuauca aaaauuauaa gcauuguuuc      420

cccgaaauuu uuggcaaggc uagugagagc cugcagcucg uguucgguau cgacgucaaa      480

gaagccgauc cuacugggca cucuuacgug uuaguaacau gccugggacu uuccuaugac      540

ggcuugcugg gcgauaacca aauuaugcca aagaccgggu uucuaaucau aguucucgug      600

augaucgcga uggagggagg ucaugcaccg gaggaagaga uuugggaaga acugucaguc      660

auggaagugu acgacggcag ggagcacagc gccuaugggg agccccggaa acuucugacg      720

caggauuugg ugcaggaaaa guaccucgag uaucgccagg ucccugacag ugauccagcu      780

agauacgagu uccugugggg acccagggcc uuagcagaga cuucuuacgu uaaagugcug      840

gaauauguaa ucaagguguc cgcucggguc cgcuuuuucu uuccuagccu ccgagaggcc      900

gcgcuuagag aggaagagga aggcguguga                                       930


<210>  2216
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A1__Homo_sapiens__AAA03229

<400>  2216
augagccugg agcagagaag ccugcacugc aagcccgagg aggcccugga ggcccagcag       60

gaggcccugg gccuggugug cgugcaggcc gccaccagca gcagcagccc ccuggugcug      120

ggcacccugg aggaggugcc caccgccggc agcaccgacc ccccccagag cccccagggc      180

gccagcgccu uccccaccac caucaacuuc accagacaga gacagcccag cgagggcagc      240

agcagcagag aggaggaggg ccccagcacc agcugcaucc uggagagccu guucagagcc      300

gugaucacca agaagguggc cgaccuggug ggcuuccugc ugcugaagua cagagccaga      360

gagcccguga ccaaggccga gaugcuggag agcgugauca agaacuacaa gcacugcuuc      420

cccgagaucu ucggcaaggc cagcgagagc cugcagcugg uguucggcau cgacgugaag      480

gaggccgacc ccaccggcca cagcuacgug cuggugaccu gccugggccu gagcuacgac      540

ggccugcugg gcgacaacca gaucaugccc aagaccggcu uccugaucau cgugcuggug      600

augaucgcca uggagggcgg ccacgccccc gaggaggaga ucugggagga gcugagcgug      660

auggaggugu acgacggcag agagcacagc gccuacggcg agcccagaaa gcugcugacc      720

caggaccugg ugcaggagaa guaccuggag uacagacagg ugcccgacag cgaccccgcc      780

agauacgagu uccugugggg ccccagagcc cuggccgaga ccagcuacgu gaaggugcug      840

gaguacguga ucaaggugag cgccagagug agauucuucu uccccagccu gagagaggcc      900

gcccugagag aggaggagga gggcguguga                                       930


<210>  2217
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A1__Homo_sapiens__AAA03229

<400>  2217
augagccugg agcagagauc ccuccacugc aagcccgaag aggcccugga agcucaacag       60

gaggcccuug gccuggugug uguccaggcg gcuaccucua gcuccucucc ucucguucug      120

gggacacuug aagaggugcc gacggccgga agcaccgauc ccccucaguc uccccaaggc      180

gccuccgcuu ucccuacaac caucaacuuu acacggcagc gccagcccag cgaggggucc      240

agcucuagag aagaggaagg accuuccacc agcugcauuc uggagucucu cuuccgggcc      300

gugaucacca aaaaggucgc ugaccuggug ggcuuucugc uccugaaaua ccgcgccaga      360

gagccgguua caaaggcgga aaugcuugag uccgugauua aaaauuauaa gcauuguuuc      420

cccgaaaucu uugggaaggc cagcgagucu cugcagcucg ucuucggaau ugacgugaaa      480

gaagcugauc cuacgggcca cuccuacguu cuggugaccu gccuuggccu gagcuaugac      540

gggcuccugg gagauaacca aaucaugccc aagacaggcu uucugaucau uguccucgug      600

augaucgcca uggaaggggg acaugcuccu gaggaagaga uuugggagga gcuguccgug      660

auggaagucu acgacggccg ggagcacucu gccuaugggg agccccgcaa acuucugacc      720

caggaucucg uucaggaaaa guaccuggag uauagacagg ugccggacag cgauccugcg      780

cgguacgagu uccuuugggg accccgcgcc cuggcugaaa cauccuacgu gaaaguccuc      840

gaauauguga ucaagguuag cgccagagug cgguuuuucu uuccuucucu gcgcgaggcu      900

gcccugagag aggaagagga aggcgucuga                                       930


<210>  2218
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A2__Homo_sapiens__P43356

<400>  2218

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Gln Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Asp Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Phe Ser Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Arg Gln Ser Asp Glu Gly Ser Ser Asn Gln Glu Glu Glu Gly Pro Arg 
                85                  90                  95      


Met Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Ile Ser Arg Lys 
            100                 105                 110         


Met Val Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Glu Ser Val Leu Arg Asn Cys Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Pro Ile Ser His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Val Met Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Ile Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Met Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Met Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Thr Leu Lys Ile Gly Gly Glu Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Arg Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  2219
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A2__Homo_sapiens__AAA17729

<400>  2219
augccucuug agcagaggag ucagcacugc aagccugaag aaggccuuga ggcccgagga       60

gaggcccugg gccugguggg ugcgcaggcu ccugcuacug aggagcagca gaccgcuucu      120

uccucuucua cucuagugga aguuacccug ggggaggugc cugcugccga cucaccgagu      180

ccuccccaca guccucaggg agccuccagc uucucgacua ccaucaacua cacucuuugg      240

agacaauccg augagggcuc cagcaaccaa gaagaggagg ggccaagaau guuucccgac      300

cuggaguccg aguuccaagc agcaaucagu aggaagaugg uugaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccgguc acaaaggcag aaaugcugga gaguguccuc      420

agaaauugcc aggacuucuu ucccgugauc uucagcaaag ccuccgagua cuugcagcug      480

gucuuuggca ucgagguggu ggaagugguc cccaucagcc acuuguacau ccuugucacc      540

ugccugggcc ucuccuacga uggccugcug ggcgacaauc aggucaugcc caagacaggc      600

cuccugauaa ucguccuggc cauaaucgca auagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugaguau guuggaggug uuugagggga gggaggacag ugucuucgca      720

caucccagga agcugcucau gcaagaucug gugcaggaaa acuaccugga guaccggcag      780

gugcccggca gugauccugc augcuacgag uuccuguggg guccaagggc ccucauugaa      840

accagcuaug ugaaaguccu gcaccauaca cuaaagaucg guggagaacc ucacauuucc      900

uacccacccc ugcaugaacg ggcuuugaga gagggagaag aguga                      945


<210>  2220
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A2__Homo_sapiens__AAA17729

<400>  2220
augccccugg agcagcgcag ccagcacugc aagccggagg agggccucga ggcccgcggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagca gaccgccucc      120

agcuccagca cgcucgucga ggugacccug ggcgaggugc ccgccgcgga cucccccagc      180

ccgccccaca gcccccaggg ggccuccucc uucagcacca ccaucaacua cacgcugugg      240

cggcaguccg acgagggcag cuccaaccag gaggaggagg gcccccggau guucccggac      300

cucgagagcg aguuccaggc cgccaucucc cgcaagaugg ucgagcuggu gcacuuccug      360

cuccugaagu accgggcgcg cgagcccgug accaaggccg agaugcugga gagcguccuc      420

cggaacugcc aggacuucuu ccccgugauc uucuccaagg ccagcgagua ccugcagcug      480

guguucggga ucgaggucgu ggaggugguc cccaucuccc accucuacau ccuggugacc      540

ugccugggcc ucagcuacga cgggcugcug ggcgacaacc aggugaugcc gaagaccggg      600

cuccugauca ucguccuggc caucaucgcc aucgagggcg acugcgcgcc cgaggagaag      660

aucugggagg agcucagcau gcuggaggug uucgagggcc gcgaggacuc cguguucgcc      720

cacccccgga agcugcucau gcaggaccug guccaggaga acuaccugga guaccgccag      780

gugcccggga gcgacccggc cugcuacgag uuccucuggg gcccccgggc ccugaucgag      840

acguccuacg ugaagguccu gcaccacacc cucaagaucg ggggcgagcc ccacaucagc      900

uacccgcccc ugcacgagcg cgcccugcgg gagggcgagg aguga                      945


<210>  2221
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A2__Homo_sapiens__AAA17729

<400>  2221
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccgcggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagca gaccgccucc      120

uccuccucca cccucgucga ggucacccuc ggcgaggucc ccgccgccga cucccccucc      180

cccccccacu ccccccaggg cgccuccucc uucuccacca ccaucaacua cacccucugg      240

cgccaguccg acgagggcuc cuccaaccag gaggaggagg gcccccgcau guuccccgac      300

cucgaguccg aguuccaggc cgccaucucc cgcaagaugg ucgagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccguc accaaggccg agaugcucga guccguccuc      420

cgcaacugcc aggacuucuu ccccgucauc uucuccaagg ccuccgagua ccuccagcuc      480

gucuucggca ucgaggucgu cgaggucguc cccaucuccc accucuacau ccucgucacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc aggucaugcc caagaccggc      600

cuccucauca ucguccucgc caucaucgcc aucgagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccau gcucgagguc uucgagggcc gcgaggacuc cgucuucgcc      720

cacccccgca agcuccucau gcaggaccuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucaucgag      840

accuccuacg ucaagguccu ccaccacacc cucaagaucg gcggcgagcc ccacaucucc      900

uacccccccc uccacgagcg cgcccuccgc gagggcgagg aguga                      945


<210>  2222
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A2__Homo_sapiens__AAA17729

<400>  2222
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agccagggga       60

gaggcucuug ggcugguggg ugcacaggcc ccagcgaccg aggaacagca gacagcuucc      120

ucuucaagua cuuuggucga gguuacguua ggcgaagugc cggccgcaga cagccccucc      180

ccuccacauu cuccccaagg ggccucguca uucagcacca caaucaacua cacucugugg      240

cggcagagug augagggauc cucuaaucag gaagaggagg gcccucgcau guuuccagac      300

cuagaaagcg aguuccaggc ugcaauuucc cgaaaaaugg uagaacucgu gcacuuucug      360

cuucugaagu accgugccag agagcccguc accaaagcug aaauguugga gucagugcuc      420

aggaacuguc aagauuucuu uccuguuaua uucaguaagg ccagcgagua ccugcagcug      480

guguuuggua ucgaagucgu ggagguaguu ccaauuucuc aucucuauau cuuagugaca      540

ugccuggggc uuuccuacga cggauugcug ggcgauaauc aggucaugcc gaaaaccggc      600

cuacucauua ucgugcuggc gauaaucgca auugaagggg acugugcccc cgaggaaaag      660

aucugggagg agcuuucaau gcuggaagug uucgagggac gggaagauag cgucuuugcu      720

cacccucgca aguugcucau gcaggaccug guucaagaga acuauuuaga auacagacag      780

gugccaggua gugaucccgc cugcuaugag uuccuguggg gcccuagggc acucauugag      840

acuucuuacg uaaaagugcu ucaucacaca cugaagaucg ggggagaacc acacauaucc      900

uaucccccgu ugcaugagcg ggcucuacgc gaaggcgagg aguga                      945


<210>  2223
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A2__Homo_sapiens__AAA17729

<400>  2223
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggccagaggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagca gaccgccagc      120

agcagcagca cccuggugga ggugacccug ggcgaggugc ccgccgccga cagccccagc      180

cccccccaca gcccccaggg cgccagcagc uucagcacca ccaucaacua cacccugugg      240

agacagagcg acgagggcag cagcaaccag gaggaggagg gccccagaau guuccccgac      300

cuggagagcg aguuccaggc cgccaucagc agaaagaugg uggagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccgug accaaggccg agaugcugga gagcgugcug      420

agaaacugcc aggacuucuu ccccgugauc uucagcaagg ccagcgagua ccugcagcug      480

guguucggca ucgagguggu ggagguggug cccaucagcc accuguacau ccuggugacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc aggugaugcc caagaccggc      600

cugcugauca ucgugcuggc caucaucgcc aucgagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcau gcuggaggug uucgagggca gagaggacag cguguucgcc      720

caccccagaa agcugcugau gcaggaccug gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugaucgag      840

accagcuacg ugaaggugcu gcaccacacc cugaagaucg gcggcgagcc ccacaucagc      900

uacccccccc ugcacgagag agcccugaga gagggcgagg aguga                      945


<210>  2224
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A2__Homo_sapiens__AAA17729

<400>  2224
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccggggc       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aggaacagca gacagccucc      120

ucuagcucca cgcuggucga gguuacccuc ggggaagugc ccgccgcuga cucuccuagc      180

ccuccccauu cuccccaagg agccuccagc uucuccacaa ccaucaacua cacacugugg      240

cgccagagcg augagggguc uuccaaucag gaagaggagg ggccuagaau guuuccggac      300

cuugaaagcg aguuccaggc ugccauuucu cggaaaaugg uggaacuggu ccacuuucuc      360

cugcugaagu accgcgcgag agagcccgug accaaagccg aaaugcucga guccguucug      420

cggaacuguc aagauuucuu uccugugauc uucagcaagg cuucugagua ccuucagcug      480

gucuuuggaa uugaaguggu ugaggugguc cccaucuccc aucucuauau ucuggugaca      540

ugccuuggcc ugagcuacga cggccuccug ggggauaauc aggugaugcc uaaaaccgga      600

cugcucauca ucguccuggc cauuaucgcu auugaaggcg acugugcccc cgaggaaaag      660

aucugggagg agcuuuccau gcuggaaguu uucgaggggc gcgaagauuc uguguuugcg      720

cacccgagaa agcuccugau gcaggaccuu gugcaagaga acuaucugga auaccggcag      780

gucccuggaa gcgaucccgc cugcuaugag uuccucuggg gcccucgcgc ucugauugag      840

acguccuacg ugaaaguucu gcaucacacc cucaagaucg ggggagaacc ccacauuagc      900

uaucccccuc ugcaugagag agcccuucgg gaaggcgagg aguga                      945


<210>  2225
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A3__Homo_sapiens__P43357

<400>  2225

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  2226
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A3__Homo_sapiens__AAA17446

<400>  2226
augccucuug agcagaggag ucagcacugc aagccugaag aaggccuuga ggcccgagga       60

gaggcccugg gccugguggg ugcgcaggcu ccugcuacug aggagcagga ggcugccucc      120

uccucuucua cucuaguuga agucacccug ggggaggugc cugcugccga gucaccagau      180

ccuccccaga guccucaggg agccuccagc cuccccacua ccaugaacua cccucucugg      240

agccaauccu augaggacuc cagcaaccaa gaagaggagg ggccaagcac cuucccugac      300

cuggaguccg aguuccaagc agcacucagu aggaaggugg ccgaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccgguc acaaaggcag aaaugcuggg gagugucguc      420

ggaaauuggc aguauuucuu uccugugauc uucagcaaag cuuccaguuc cuugcagcug      480

gucuuuggca ucgagcugau ggaaguggac cccaucggcc acuuguacau cuuugccacc      540

ugccugggcc ucuccuacga uggccugcug ggugacaauc agaucaugcc caaggcaggc      600

cuccugauaa ucguccuggc cauaaucgca agagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugagugu guuagaggug uuugagggga gggaagacag uaucuugggg      720

gaucccaaga agcugcucac ccaacauuuc gugcaggaaa acuaccugga guaccggcag      780

guccccggca gugauccugc auguuaugaa uuccuguggg guccaagggc ccucguugaa      840

accagcuaug ugaaaguccu gcaccauaug guaaagauca guggaggacc ucacauuucc      900

uacccacccc ugcaugagug gguuuugaga gagggggaag aguga                      945


<210>  2227
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A3__Homo_sapiens__AAA17446

<400>  2227
augccccugg agcagcgcag ccagcacugc aagcccgagg agggccucga ggcccgcggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagga ggccgccucc      120

agcuccagca cccucgucga ggugacgcug ggcgaggugc ccgcggccga gucccccgac      180

ccgccccaga gcccccaggg ggccuccagc cugcccacca ccaugaacua cccgcucugg      240

ucccagagcu acgaggacuc cagcaaccag gaggaggagg gccccuccac cuuccccgac      300

cuggagagcg aguuccaggc cgcgcugucc cggaaggucg ccgagcucgu gcacuuccug      360

cugcucaagu accgggcccg cgagcccgug acgaaggccg agaugcuggg cagcgucgug      420

gggaacuggc aguacuucuu cccggugauc uucuccaagg ccagcuccag ccugcagcuc      480

gucuucggca ucgagcugau ggagguggac cccaucgggc accuguacau cuucgcgacc      540

ugccucggcc ugagcuacga cgggcugcuc ggcgacaacc agaucaugcc caaggccggc      600

cugcugauca ucgugcucgc caucaucgcc cgggaggggg acugcgcccc cgaggagaag      660

aucugggagg agcuguccgu ccuggaggug uucgagggcc gcgaggacag cauccucggg      720

gacccgaaga agcugcugac ccagcacuuc gugcaggaga acuaccucga guaccggcag      780

guccccggcu ccgaccccgc gugcuacgag uuccuguggg gcccccgcgc ccugguggag      840

accagcuacg ugaagguccu ccaccacaug gugaagaucu ccgggggccc gcacaucagc      900

uacccgcccc ugcacgagug ggugcugcgg gagggggagg aguga                      945


<210>  2228
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A3__Homo_sapiens__AAA17446

<400>  2228
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccgcggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagga ggccgccucc      120

uccuccucca cccucgucga ggucacccuc ggcgaggucc ccgccgccga gucccccgac      180

cccccccagu ccccccaggg cgccuccucc cuccccacca ccaugaacua cccccucugg      240

ucccaguccu acgaggacuc cuccaaccag gaggaggagg gccccuccac cuuccccgac      300

cucgaguccg aguuccaggc cgcccucucc cgcaaggucg ccgagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccguc accaaggccg agaugcucgg cuccgucguc      420

ggcaacuggc aguacuucuu ccccgucauc uucuccaagg ccuccuccuc ccuccagcuc      480

gucuucggca ucgagcucau ggaggucgac cccaucggcc accucuacau cuucgccacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc agaucaugcc caaggccggc      600

cuccucauca ucguccucgc caucaucgcc cgcgagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccgu ccucgagguc uucgagggcc gcgaggacuc cauccucggc      720

gaccccaaga agcuccucac ccagcacuuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucgucgag      840

accuccuacg ucaagguccu ccaccacaug gucaagaucu ccggcggccc ccacaucucc      900

uacccccccc uccacgagug gguccuccgc gagggcgagg aguga                      945


<210>  2229
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A3__Homo_sapiens__AAA17446

<400>  2229
augccccugg agcagagaag ccagcacugc aagccugaag agggccucga agccagggga       60

gaggcucuug ggcugguggg ugcacaggcc ccagcgaccg aggaacagga ggcugccucc      120

ucuucaagua cauuggucga aguuacuuua ggcgaggugc cggcagccga aagccccgac      180

ccuccacaga gcccccaagg ggcuucuucg cugccuacga ccaugaacua cccacuaugg      240

ucacagagcu augaggauag uuccaaucag gaggaagagg gacccucuac auucccugac      300

cucgaaagcg aguuucaggc agcccugucc cggaaaguag cugaacuugu gcauuuccug      360

uugcucaagu accgcgcccg agagccaguc acuaaagcgg agaugcuggg cucagugguu      420

gguaacuggc aauacuuuuu cccggugauc uuuaguaagg cauccucuuc ccugcagcuc      480

gucuucggga uugaauuaau ggagguggau cccauaggac accuguauau cuuugccacc      540

ugucuuggcu ugucauauga cggccugcua ggggauaauc agauuaugcc uaaagcugga      600

cuccugauca uuguacuugc caucauagca cgugaaggug acugcgcucc agaggaaaag      660

aucugggagg agcugagcgu uuuggaagug uucgagggca gagaagauag uauucucggg      720

gaccccaaga aacuguuaac acagcauuuu guccaagaga acuaccugga auauaggcaa      780

gugccuggau cugauccagc cuguuacgag uuccucuggg gcccccgggc gcuuguggag      840

accuccuacg ucaagguucu gcaccauaug gugaaaauca gcggugggcc gcacauuucg      900

uauccucccu ugcacgaaug gguacuacgc gagggagaag aguga                      945


<210>  2230
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A3__Homo_sapiens__AAA17446

<400>  2230
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggccagaggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagga ggccgccagc      120

agcagcagca cccuggugga ggugacccug ggcgaggugc ccgccgccga gagccccgac      180

cccccccaga gcccccaggg cgccagcagc cugcccacca ccaugaacua cccccugugg      240

agccagagcu acgaggacag cagcaaccag gaggaggagg gccccagcac cuuccccgac      300

cuggagagcg aguuccaggc cgcccugagc agaaaggugg ccgagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccgug accaaggccg agaugcuggg cagcguggug      420

ggcaacuggc aguacuucuu ccccgugauc uucagcaagg ccagcagcag ccugcagcug      480

guguucggca ucgagcugau ggagguggac cccaucggcc accuguacau cuucgccacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc agaucaugcc caaggccggc      600

cugcugauca ucgugcuggc caucaucgcc agagagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu gcuggaggug uucgagggca gagaggacag cauccugggc      720

gaccccaaga agcugcugac ccagcacuuc gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugguggag      840

accagcuacg ugaaggugcu gcaccacaug gugaagauca gcggcggccc ccacaucagc      900

uacccccccc ugcacgagug ggugcugaga gagggcgagg aguga                      945


<210>  2231
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A3__Homo_sapiens__AAA17446

<400>  2231
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccgcggg       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aggaacagga ggccgccucc      120

ucuagcucca cacuggucga aguuacgcuc ggggaggugc ccgcugccga aucuccugau      180

cccccucaga gcccccaagg agcuuccucu cugccuacca caaugaacua cccgcuuugg      240

agccaguccu augaggacag cucuaaucag gaggaagagg gccccuccac cuucccugac      300

cuggaaagcg aguuucaggc cgcgcucucu cggaaagugg ccgaacuggu ccauuuccug      360

cuccugaagu acagagcucg ggagcccgug acaaaagccg agaugcuugg guccguugug      420

ggaaacuggc aauacuuuuu cccugucauc uuuagcaagg cuucuuccag ccugcagcuc      480

guguucggca uugaacugau ggagguugau cccaucggcc accuuuauau uuuugccacc      540

ugucuggggc ucuccuauga cggacugcug ggcgauaauc agaucaugcc gaaagcgggg      600

cuccugauua ucgugcuugc caucauugcu cgcgaaggag acugcgcccc ugaggaaaag      660

aucugggagg agcugucugu ccucgaagug uucgagggca gagaagauag cauucugggg      720

gaccccaaga aacuucugac acagcauuuu gugcaagaga acuaccucga auaucggcag      780

gucccuggau ccgaucccgc uuguuacgag uuccuguggg gcccccgcgc ccugguugag      840

accagcuacg ugaaggugcu ccaccauaug gucaaaaucu cuggcgggcc ucacauuucc      900

uauccgcccc ugcacgaaug ggugcuuaga gagggagaag aguga                      945


<210>  2232
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__A0A024RC12

<400>  2232

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  2233
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__EAW99410

<400>  2233
augucuucug agcagaagag ucagcacugc aagccugagg aaggcguuga ggcccaagaa       60

gaggcccugg gccugguggg ugcacaggcu ccuacuacug aggagcagga ggcugcuguc      120

uccuccuccu cuccucuggu cccuggcacc cuggaggaag ugccugcugc ugagucagca      180

gguccucccc agaguccuca gggagccucu gccuuaccca cuaccaucag cuucacuugc      240

uggaggcaac ccaaugaggg uuccagcagc caagaagagg aggggccaag caccucgccu      300

gacgcagagu ccuuguuccg agaagcacuc aguaacaagg uggaugaguu ggcucauuuu      360

cugcuccgca aguaucgagc caaggagcug gucacaaagg cagaaaugcu ggagagaguc      420

aucaaaaauu acaagcgcug cuuuccugug aucuucggca aagccuccga gucccugaag      480

augaucuuug gcauugacgu gaaggaagug gaccccgcca gcaacaccua cacccuuguc      540

accugccugg gccuuuccua ugauggccug cuggguaaua aucagaucuu ucccaagaca      600

ggccuucuga uaaucguccu gggcacaauu gcaauggagg gcgacagcgc cucugaggag      660

gaaaucuggg aggagcuggg ugugaugggg guguaugaug ggagggagca cacugucuau      720

ggggagccca ggaaacugcu cacccaagau ugggugcagg aaaacuaccu ggaguaccgg      780

cagguacccg gcaguaaucc ugcgcgcuau gaguuccugu gggguccaag ggcucuggcu      840

gaaaccagcu augugaaagu ccuggagcau guggucaggg ucaaugcaag aguucgcauu      900

gccuacccau cccugcguga agcagcuuug uuagaggagg aagagggagu cuga            954


<210>  2234
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A4__Homo_sapiens__EAW99410

<400>  2234
augagcuccg agcagaaguc ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg ggcucgucgg cgcgcaggcc ccgaccaccg aggagcagga ggccgccgug      120

agcagcucca gcccccuggu gcccgggacg cuggaggagg uccccgccgc ggaguccgcc      180

ggcccgcccc agagccccca gggggccucc gcccucccca ccaccaucag cuucacgugc      240

uggcgccagc cgaacgaggg cuccagcucc caggaggagg agggccccag caccuccccc      300

gacgcggaga gccuguuccg ggaggcccug uccaacaagg uggacgagcu cgcccacuuc      360

cugcugcgca aguaccgggc caaggagcuc gugaccaagg ccgagaugcu ggagcgcguc      420

aucaagaacu acaagcggug cuuccccgug aucuucggga aggcgagcga gucccugaag      480

augaucuucg gcaucgacgu gaaggagguc gacccggcca gcaacaccua cacccucgug      540

acgugccugg ggcugagcua cgacggccuc cuggggaaca accagaucuu ccccaagacc      600

ggccugcuca ucaucgugcu gggcaccauc gccauggagg gggacuccgc cagcgaggag      660

gagaucuggg aggagcuggg cgucaugggg guguacgacg gccgcgagca caccguguac      720

ggcgagcccc ggaagcuccu gacgcaggac uggguccagg agaacuaccu ggaguaccgc      780

caggugcccg gguccaaccc ggcccgguac gaguuccucu ggggcccccg cgcgcuggcc      840

gagaccagcu acgugaaggu ccuggagcac guggugcggg ucaacgcccg cgugcggauc      900

gccuaccccu cccuccgcga ggccgcgcug cuggaggagg aggagggggu guga            954


<210>  2235
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A4__Homo_sapiens__EAW99410

<400>  2235
auguccuccg agcagaaguc ccagcacugc aagcccgagg agggcgucga ggcccaggag       60

gaggcccucg gccucgucgg cgcccaggcc cccaccaccg aggagcagga ggccgccguc      120

uccuccuccu ccccccucgu ccccggcacc cucgaggagg uccccgccgc cgaguccgcc      180

ggcccccccc agucccccca gggcgccucc gcccucccca ccaccaucuc cuucaccugc      240

uggcgccagc ccaacgaggg cuccuccucc caggaggagg agggccccuc caccuccccc      300

gacgccgagu cccucuuccg cgaggcccuc uccaacaagg ucgacgagcu cgcccacuuc      360

cuccuccgca aguaccgcgc caaggagcuc gucaccaagg ccgagaugcu cgagcgcguc      420

aucaagaacu acaagcgcug cuuccccguc aucuucggca aggccuccga gucccucaag      480

augaucuucg gcaucgacgu caaggagguc gaccccgccu ccaacaccua cacccucguc      540

accugccucg gccucuccua cgacggccuc cucggcaaca accagaucuu ccccaagacc      600

ggccuccuca ucaucguccu cggcaccauc gccauggagg gcgacuccgc cuccgaggag      660

gagaucuggg aggagcucgg cgucaugggc gucuacgacg gccgcgagca caccgucuac      720

ggcgagcccc gcaagcuccu cacccaggac uggguccagg agaacuaccu cgaguaccgc      780

cagguccccg gcuccaaccc cgcccgcuac gaguuccucu ggggcccccg cgcccucgcc      840

gagaccuccu acgucaaggu ccucgagcac gucguccgcg ucaacgcccg cguccgcauc      900

gccuaccccu cccuccgcga ggccgcccuc cucgaggagg aggagggcgu cuga            954


<210>  2236
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A4__Homo_sapiens__EAW99410

<400>  2236
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcacaggcc ccuaccacag aggagcagga agcggcuguu      120

ucaaguagcu ccccacuugu gccggguacu cuggaggaag uacccgccgc agagucugcc      180

ggcccuccac aaucgcccca gggggcuuca gcauugccua cgaccaucag cuucacaugu      240

uggagacagc caaacgaggg aaguuccucu caggaagagg aaggccccag cacuuccccu      300

gacgccgagu cauuauuuag ggaagcucug aguaauaagg uggaugagcu agcccauuuc      360

cuccugcgga aauaccgcgc gaaggagcuu gucaccaaag cagaaaugcu ggagcgagug      420

auuaagaacu auaagcguug cuuuccaguu auauucggua aagccagcga aucuuugaag      480

augaucuuug ggauugacgu gaaagagguc gauccggcuu ccaauacaua cacccucgug      540

acuugucugg gacugucaua ugacggccuc uuaggcaaca aucaaaucuu ccccaagaca      600

gggcugcuua uuaucguauu gggaaccaua gccauggaag gugauagcgc aagugaggag      660

gaaaucuggg aggaacuggg cguuaugggg guguacgacg gaagagagca cacggucuau      720

ggcgaaccua ggaaacuacu cacucaggau ugggugcagg agaacuaccu ggaguaucgc      780

caggugccag guucuaaucc cgcucgguac gaauuucuuu gggggccuag agcccuggcg      840

gagaccuccu acgucaaggu uuuggaacau gugguaaggg ugaacgcccg gguccgcauu      900

gcauauccaa gccuccgaga ggcugcccug uuagaggaag aggaaggagu guga            954


<210>  2237
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A4__Homo_sapiens__EAW99410

<400>  2237
augagcagcg agcagaagag ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg gccugguggg cgcccaggcc cccaccaccg aggagcagga ggccgccgug      120

agcagcagca gcccccuggu gcccggcacc cuggaggagg ugcccgccgc cgagagcgcc      180

ggcccccccc agagccccca gggcgccagc gcccugccca ccaccaucag cuucaccugc      240

uggagacagc ccaacgaggg cagcagcagc caggaggagg agggccccag caccagcccc      300

gacgccgaga gccuguucag agaggcccug agcaacaagg uggacgagcu ggcccacuuc      360

cugcugagaa aguacagagc caaggagcug gugaccaagg ccgagaugcu ggagagagug      420

aucaagaacu acaagagaug cuuccccgug aucuucggca aggccagcga gagccugaag      480

augaucuucg gcaucgacgu gaaggaggug gaccccgcca gcaacaccua cacccuggug      540

accugccugg gccugagcua cgacggccug cugggcaaca accagaucuu ccccaagacc      600

ggccugcuga ucaucgugcu gggcaccauc gccauggagg gcgacagcgc cagcgaggag      660

gagaucuggg aggagcuggg cgugaugggc guguacgacg gcagagagca caccguguac      720

ggcgagccca gaaagcugcu gacccaggac ugggugcagg agaacuaccu ggaguacaga      780

caggugcccg gcagcaaccc cgccagauac gaguuccugu ggggccccag agcccuggcc      840

gagaccagcu acgugaaggu gcuggagcac guggugagag ugaacgccag agugagaauc      900

gccuacccca gccugagaga ggccgcccug cuggaggagg aggagggcgu guga            954


<210>  2238
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A4__Homo_sapiens__EAW99410

<400>  2238
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcccaggcg ccuaccacag aggagcagga agcugccguu      120

agcuccucua gcccgcuggu gcccggcacg cuugaggaag ugccugccgc ugaguccgcc      180

gggcccccuc aaucucccca gggagcuagc gcccugccua ccacaaucuc cuucaccugu      240

uggagacagc cgaacgaggg cucuagcucc caggaagagg aagggcccag cacaucuccu      300

gacgcggagu cccucuuucg ggaagcccug agcaauaagg ucgaugagcu ugcucauuuc      360

cugcuccgca aauacagagc caaggagcug gugaccaaag cugaaaugcu ggagcggguu      420

auuaagaacu auaagcgcug cuuucccgug aucuucggaa aagccucuga aucccucaag      480

augauuuuug gcaucgacgu caaagaggug gauccugcga gcaauacaua cacccugguu      540

acgugucuug gccuguccua ugacgggcuc cugggaaaca aucaaauuuu ccccaagacc      600

ggccuucuga ucaucgugcu cgggacaauu gccauggaag gagauucugc uagcgaggag      660

gaaaucuggg aggaacuggg cgucaugggg guguacgacg gaagagagca caccguguau      720

ggcgaaccgc ggaaacugcu cacacaggau uggguccagg agaacuaccu ggaguaucgc      780

cagguuccug gcuccaaucc cgccagauac gaauuucuuu gggggccucg ggcucuggcc      840

gagaccagcu acgugaaggu gcucgaacau gucgugcgcg uuaacgccag agugcggauu      900

gcuuaucccu cucugcgcga ggcggcccuu cuggaggaag aggaaggagu cuga            954


<210>  2239
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__P43358

<400>  2239

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  2240
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__AAA68871

<400>  2240
augucuucug agcagaagag ucagcacugc aagccugagg aaggcguuga ggcccaagaa       60

gaggcccugg gccugguggg ugcacaggcu ccuacuacug aggagcagga ggcugcuguc      120

uccuccuccu cuccucuggu cccuggcacc cuggaggaag ugccugcugc ugagucagca      180

gguccucccc agaguccuca gggagccucu gccuuaccca cuaccaucag cuucacuugc      240

uggaggcaac ccaaugaggg uuccagcagc caagaagagg aggggccaag caccucgccu      300

gacgcagagu ccuuguuccg agaagcacuc aguaacaagg uggaugaguu ggcucauuuu      360

cugcuccgca aguaucgagc caaggagcug gucacaaagg cagaaaugcu ggagagaguc      420

aucaaaaauu acaagcgcug cuuuccugug aucuucggca aagccuccga gucccugaag      480

augaucuuug gcauugacgu gaaggaagug gaccccgcca gcaacaccua cacccuuguc      540

accugccugg gccuuuccua ugauggccug cuggguaaua aucagaucuu ucccaagaca      600

ggccuucuga uaaucguccu gggcacaauu gcaauggagg gcgacagcgc cucugaggag      660

gaaaucuggg aggagcuggg ugugaugggg guguaugaug ggagggagca cacugucuau      720

ggggagccca ggaaacugcu cacccaagau ugggugcagg aaaacuaccu ggaguaccgg      780

cagguacccg gcaguaaucc ugcgcgcuau gaguuccugu gggguccaag ggcucuggcu      840

gaaaccagcu augugaaagu ccuggagcau guggucaggg ucaaugcaag aguucgcauu      900

gccuacccau cccugcguga agcagcuuug uuagaggagg aagagggagu cuga            954


<210>  2241
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A4__Homo_sapiens__AAA68871

<400>  2241
augagcuccg agcagaaguc ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg ggcucgucgg cgcgcaggcc ccgaccaccg aggagcagga ggccgccgug      120

agcagcucca gcccccuggu gcccgggacg cuggaggagg uccccgccgc ggaguccgcc      180

ggcccgcccc agagccccca gggggccucc gcccucccca ccaccaucag cuucacgugc      240

uggcgccagc cgaacgaggg cuccagcucc caggaggagg agggccccag caccuccccc      300

gacgcggaga gccuguuccg ggaggcccug uccaacaagg uggacgagcu cgcccacuuc      360

cugcugcgca aguaccgggc caaggagcuc gugaccaagg ccgagaugcu ggagcgcguc      420

aucaagaacu acaagcggug cuuccccgug aucuucggga aggcgagcga gucccugaag      480

augaucuucg gcaucgacgu gaaggagguc gacccggcca gcaacaccua cacccucgug      540

acgugccugg ggcugagcua cgacggccuc cuggggaaca accagaucuu ccccaagacc      600

ggccugcuca ucaucgugcu gggcaccauc gccauggagg gggacuccgc cagcgaggag      660

gagaucuggg aggagcuggg cgucaugggg guguacgacg gccgcgagca caccguguac      720

ggcgagcccc ggaagcuccu gacgcaggac uggguccagg agaacuaccu ggaguaccgc      780

caggugcccg gguccaaccc ggcccgguac gaguuccucu ggggcccccg cgcgcuggcc      840

gagaccagcu acgugaaggu ccuggagcac guggugcggg ucaacgcccg cgugcggauc      900

gccuaccccu cccuccgcga ggccgcgcug cuggaggagg aggagggggu guga            954


<210>  2242
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A4__Homo_sapiens__AAA68871

<400>  2242
auguccuccg agcagaaguc ccagcacugc aagcccgagg agggcgucga ggcccaggag       60

gaggcccucg gccucgucgg cgcccaggcc cccaccaccg aggagcagga ggccgccguc      120

uccuccuccu ccccccucgu ccccggcacc cucgaggagg uccccgccgc cgaguccgcc      180

ggcccccccc agucccccca gggcgccucc gcccucccca ccaccaucuc cuucaccugc      240

uggcgccagc ccaacgaggg cuccuccucc caggaggagg agggccccuc caccuccccc      300

gacgccgagu cccucuuccg cgaggcccuc uccaacaagg ucgacgagcu cgcccacuuc      360

cuccuccgca aguaccgcgc caaggagcuc gucaccaagg ccgagaugcu cgagcgcguc      420

aucaagaacu acaagcgcug cuuccccguc aucuucggca aggccuccga gucccucaag      480

augaucuucg gcaucgacgu caaggagguc gaccccgccu ccaacaccua cacccucguc      540

accugccucg gccucuccua cgacggccuc cucggcaaca accagaucuu ccccaagacc      600

ggccuccuca ucaucguccu cggcaccauc gccauggagg gcgacuccgc cuccgaggag      660

gagaucuggg aggagcucgg cgucaugggc gucuacgacg gccgcgagca caccgucuac      720

ggcgagcccc gcaagcuccu cacccaggac uggguccagg agaacuaccu cgaguaccgc      780

cagguccccg gcuccaaccc cgcccgcuac gaguuccucu ggggcccccg cgcccucgcc      840

gagaccuccu acgucaaggu ccucgagcac gucguccgcg ucaacgcccg cguccgcauc      900

gccuaccccu cccuccgcga ggccgcccuc cucgaggagg aggagggcgu cuga            954


<210>  2243
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A4__Homo_sapiens__AAA68871

<400>  2243
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcacaggcc ccuaccacag aggagcagga agcggcuguu      120

ucaaguagcu ccccacuugu gccggguacu cuggaggaag uacccgccgc agagucugcc      180

ggcccuccac aaucgcccca gggggcuuca gcauugccua cgaccaucag cuucacaugu      240

uggagacagc caaacgaggg aaguuccucu caggaagagg aaggccccag cacuuccccu      300

gacgccgagu cauuauuuag ggaagcucug aguaauaagg uggaugagcu agcccauuuc      360

cuccugcgga aauaccgcgc gaaggagcuu gucaccaaag cagaaaugcu ggagcgagug      420

auuaagaacu auaagcguug cuuuccaguu auauucggua aagccagcga aucuuugaag      480

augaucuuug ggauugacgu gaaagagguc gauccggcuu ccaauacaua cacccucgug      540

acuugucugg gacugucaua ugacggccuc uuaggcaaca aucaaaucuu ccccaagaca      600

gggcugcuua uuaucguauu gggaaccaua gccauggaag gugauagcgc aagugaggag      660

gaaaucuggg aggaacuggg cguuaugggg guguacgacg gaagagagca cacggucuau      720

ggcgaaccua ggaaacuacu cacucaggau ugggugcagg agaacuaccu ggaguaucgc      780

caggugccag guucuaaucc cgcucgguac gaauuucuuu gggggccuag agcccuggcg      840

gagaccuccu acgucaaggu uuuggaacau gugguaaggg ugaacgcccg gguccgcauu      900

gcauauccaa gccuccgaga ggcugcccug uuagaggaag aggaaggagu guga            954


<210>  2244
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A4__Homo_sapiens__AAA68871

<400>  2244
augagcagcg agcagaagag ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg gccugguggg cgcccaggcc cccaccaccg aggagcagga ggccgccgug      120

agcagcagca gcccccuggu gcccggcacc cuggaggagg ugcccgccgc cgagagcgcc      180

ggcccccccc agagccccca gggcgccagc gcccugccca ccaccaucag cuucaccugc      240

uggagacagc ccaacgaggg cagcagcagc caggaggagg agggccccag caccagcccc      300

gacgccgaga gccuguucag agaggcccug agcaacaagg uggacgagcu ggcccacuuc      360

cugcugagaa aguacagagc caaggagcug gugaccaagg ccgagaugcu ggagagagug      420

aucaagaacu acaagagaug cuuccccgug aucuucggca aggccagcga gagccugaag      480

augaucuucg gcaucgacgu gaaggaggug gaccccgcca gcaacaccua cacccuggug      540

accugccugg gccugagcua cgacggccug cugggcaaca accagaucuu ccccaagacc      600

ggccugcuga ucaucgugcu gggcaccauc gccauggagg gcgacagcgc cagcgaggag      660

gagaucuggg aggagcuggg cgugaugggc guguacgacg gcagagagca caccguguac      720

ggcgagccca gaaagcugcu gacccaggac ugggugcagg agaacuaccu ggaguacaga      780

caggugcccg gcagcaaccc cgccagauac gaguuccugu ggggccccag agcccuggcc      840

gagaccagcu acgugaaggu gcuggagcac guggugagag ugaacgccag agugagaauc      900

gccuacccca gccugagaga ggccgcccug cuggaggagg aggagggcgu guga            954


<210>  2245
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A4__Homo_sapiens__AAA68871

<400>  2245
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcccaggcg ccuaccacag aggagcagga agcugccguu      120

agcuccucua gcccgcuggu gcccggcacg cuugaggaag ugccugccgc ugaguccgcc      180

gggcccccuc aaucucccca gggagcuagc gcccugccua ccacaaucuc cuucaccugu      240

uggagacagc cgaacgaggg cucuagcucc caggaagagg aagggcccag cacaucuccu      300

gacgcggagu cccucuuucg ggaagcccug agcaauaagg ucgaugagcu ugcucauuuc      360

cugcuccgca aauacagagc caaggagcug gugaccaaag cugaaaugcu ggagcggguu      420

auuaagaacu auaagcgcug cuuucccgug aucuucggaa aagccucuga aucccucaag      480

augauuuuug gcaucgacgu caaagaggug gauccugcga gcaauacaua cacccugguu      540

acgugucuug gccuguccua ugacgggcuc cugggaaaca aucaaauuuu ccccaagacc      600

ggccuucuga ucaucgugcu cgggacaauu gccauggaag gagauucugc uagcgaggag      660

gaaaucuggg aggaacuggg cgucaugggg guguacgacg gaagagagca caccguguau      720

ggcgaaccgc ggaaacugcu cacacaggau uggguccagg agaacuaccu ggaguaucgc      780

cagguuccug gcuccaaucc cgccagauac gaauuucuuu gggggccucg ggcucuggcc      840

gagaccagcu acgugaaggu gcucgaacau gucgugcgcg uuaacgccag agugcggauu      900

gcuuaucccu cucugcgcga ggcggcccuu cuggaggaag aggaaggagu cuga            954


<210>  2246
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__Q1RN33

<400>  2246

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Thr Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  2247
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A4__Homo_sapiens__AAY27261

<400>  2247
augucuucug agcagaagag ucagcacugc aagccugagg aaggcguuga ggcccaagaa       60

gaggcccugg gccugguggg ugcgcaggcu ccuacuacug aggagcagga ggcugcuguc      120

uccuccuccu cuccucuggu cccuggcacc cuggaggaag ugccugcugc ugagucagca      180

gguccucccc agaguccuca gggagccucu gccuuaccca cuaccaucag cuucacuugc      240

uggaggcaac ccaaugaggg uuccagcagc caagaagagg aggggccaag caccucgccu      300

gacgcagagu ccuuguuccg agaagcacuc aguaacaagg uggaugaguu ggcucauuuu      360

cugcuccgca aguaucgagc caaggagcug gucacaaagg cagaaaugcu ggagagaguc      420

aucaaaaauu acaagcgcug cuuuccugug aucuucggca aagccuccga gucccugaag      480

augaucuuug gcauugacgu gaaggaagug gaccccacca gcaacaccua cacccuuguc      540

accugccugg gccuuuccua ugauggccug cuggguaaua aucagaucuu ucccaagaca      600

ggccuucuga uaaucguccu gggcacaauu gcaauggagg gcgacagcgc cucugaggag      660

gaaaucuggg aggagcuggg ugugaugggg guguaugaug ggagggagca cacugucuau      720

ggggagccca ggaaacugcu cacccaagau ugggugcagg aaaacuaccu ggaguaccgg      780

cagguacccg gcaguaaucc ugcgcgcuau gaguuccugu gggguccaag ggcucuggcu      840

gaaaccagcu augugaaagu ccuggagcau guggucaggg ucaaugcaag aguucgcauu      900

gccuacccau cccugcguga agcagcuuug uuagaggagg aagagggagu cuga            954


<210>  2248
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A4__Homo_sapiens__AAY27261

<400>  2248
augagcuccg agcagaaguc ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg ggcucgucgg cgcgcaggcc ccgaccaccg aggagcagga ggccgccgug      120

agcagcucca gcccccuggu gcccgggacg cuggaggagg uccccgccgc ggaguccgcc      180

ggcccgcccc agagccccca gggggccucc gcccucccca ccaccaucag cuucacgugc      240

uggcgccagc cgaacgaggg cuccagcucc caggaggagg agggccccag caccuccccc      300

gacgcggaga gccuguuccg ggaggcccug uccaacaagg uggacgagcu cgcccacuuc      360

cugcugcgca aguaccgggc caaggagcuc gugaccaagg ccgagaugcu ggagcgcguc      420

aucaagaacu acaagcggug cuuccccgug aucuucggga aggcgagcga gucccugaag      480

augaucuucg gcaucgacgu gaaggagguc gacccgacca gcaacaccua cacgcucgug      540

accugccugg ggcugagcua cgacggccuc cuggggaaca accagaucuu ccccaagacc      600

ggccugcuca ucaucgugcu gggcaccauc gccauggagg gggacuccgc cagcgaggag      660

gagaucuggg aggagcuggg cgucaugggg guguacgacg gccgcgagca cacgguguac      720

ggcgagcccc ggaagcuccu gacccaggac uggguccagg agaacuaccu ggaguaccgc      780

caggugcccg gguccaaccc ggcccgguac gaguuccucu ggggcccccg cgcccuggcg      840

gagaccagcu acgugaaggu ccuggagcac guggugcggg ucaacgcccg cgugcggauc      900

gccuaccccu cccuccgcga ggccgcccug cuggaggagg aggagggggu guga            954


<210>  2249
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A4__Homo_sapiens__AAY27261

<400>  2249
auguccuccg agcagaaguc ccagcacugc aagcccgagg agggcgucga ggcccaggag       60

gaggcccucg gccucgucgg cgcccaggcc cccaccaccg aggagcagga ggccgccguc      120

uccuccuccu ccccccucgu ccccggcacc cucgaggagg uccccgccgc cgaguccgcc      180

ggcccccccc agucccccca gggcgccucc gcccucccca ccaccaucuc cuucaccugc      240

uggcgccagc ccaacgaggg cuccuccucc caggaggagg agggccccuc caccuccccc      300

gacgccgagu cccucuuccg cgaggcccuc uccaacaagg ucgacgagcu cgcccacuuc      360

cuccuccgca aguaccgcgc caaggagcuc gucaccaagg ccgagaugcu cgagcgcguc      420

aucaagaacu acaagcgcug cuuccccguc aucuucggca aggccuccga gucccucaag      480

augaucuucg gcaucgacgu caaggagguc gaccccaccu ccaacaccua cacccucguc      540

accugccucg gccucuccua cgacggccuc cucggcaaca accagaucuu ccccaagacc      600

ggccuccuca ucaucguccu cggcaccauc gccauggagg gcgacuccgc cuccgaggag      660

gagaucuggg aggagcucgg cgucaugggc gucuacgacg gccgcgagca caccgucuac      720

ggcgagcccc gcaagcuccu cacccaggac uggguccagg agaacuaccu cgaguaccgc      780

cagguccccg gcuccaaccc cgcccgcuac gaguuccucu ggggcccccg cgcccucgcc      840

gagaccuccu acgucaaggu ccucgagcac gucguccgcg ucaacgcccg cguccgcauc      900

gccuaccccu cccuccgcga ggccgcccuc cucgaggagg aggagggcgu cuga            954


<210>  2250
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A4__Homo_sapiens__AAY27261

<400>  2250
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcacaggcc ccuaccacag aggagcagga agcggcuguu      120

ucaaguagcu ccccacuugu gccggguacu cuggaggaag uacccgccgc agagucugcc      180

ggcccuccac aaucgcccca gggggcuuca gcauugccua cgaccaucag cuucacaugu      240

uggagacagc caaacgaggg aaguuccucu caggaagagg aaggccccag cacuuccccu      300

gacgccgagu cauuauuuag ggaagcucug aguaauaagg uggaugagcu agcccauuuc      360

cuccugcgga aauaccgcgc gaaggagcuu gucaccaaag cagaaaugcu ggagcgagug      420

auuaagaacu auaagcguug cuuuccaguu auauucggua aagccagcga aucuuugaag      480

augaucuuug ggauugacgu gaaagagguc gauccgacau ccaauaccua cacucucgug      540

acaugucugg gacugucaua ugacggccuc uuaggcaaca aucaaaucuu ccccaagacc      600

gggcugcuua uuaucguauu gggaacgaua gcuauggaag gugauagcgc cagugaggag      660

gaaaucuggg aggaacuggg cguuaugggg guguacgacg gaagagagca cacugucuau      720

ggcgaaccua ggaaacuacu cacccaggau ugggugcagg agaacuaccu ggaguaucgc      780

caggugccag guucuaaucc cgcacgguac gaauuucuuu gggggccuag agcucuggcc      840

gagacauccu acgucaaggu uuuggaacau gugguaaggg ugaacgcgcg gguccgcauu      900

gccuauccaa gccuccgaga ggcagcucug uuagaggaag aggaaggagu guga            954


<210>  2251
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A4__Homo_sapiens__AAY27261

<400>  2251
augagcagcg agcagaagag ccagcacugc aagcccgagg agggcgugga ggcccaggag       60

gaggcccugg gccugguggg cgcccaggcc cccaccaccg aggagcagga ggccgccgug      120

agcagcagca gcccccuggu gcccggcacc cuggaggagg ugcccgccgc cgagagcgcc      180

ggcccccccc agagccccca gggcgccagc gcccugccca ccaccaucag cuucaccugc      240

uggagacagc ccaacgaggg cagcagcagc caggaggagg agggccccag caccagcccc      300

gacgccgaga gccuguucag agaggcccug agcaacaagg uggacgagcu ggcccacuuc      360

cugcugagaa aguacagagc caaggagcug gugaccaagg ccgagaugcu ggagagagug      420

aucaagaacu acaagagaug cuuccccgug aucuucggca aggccagcga gagccugaag      480

augaucuucg gcaucgacgu gaaggaggug gaccccacca gcaacaccua cacccuggug      540

accugccugg gccugagcua cgacggccug cugggcaaca accagaucuu ccccaagacc      600

ggccugcuga ucaucgugcu gggcaccauc gccauggagg gcgacagcgc cagcgaggag      660

gagaucuggg aggagcuggg cgugaugggc guguacgacg gcagagagca caccguguac      720

ggcgagccca gaaagcugcu gacccaggac ugggugcagg agaacuaccu ggaguacaga      780

caggugcccg gcagcaaccc cgccagauac gaguuccugu ggggccccag agcccuggcc      840

gagaccagcu acgugaaggu gcuggagcac guggugagag ugaacgccag agugagaauc      900

gccuacccca gccugagaga ggccgcccug cuggaggagg aggagggcgu guga            954


<210>  2252
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A4__Homo_sapiens__AAY27261

<400>  2252
augagcuccg agcagaaguc ucaacacugc aaacccgaag agggcgugga agcccaggag       60

gaagcucugg ggcucgucgg agcccaggcg ccuaccacag aggagcagga agcugccguu      120

agcuccucua gcccgcuggu gcccggcacg cuugaggaag ugccugccgc ugaguccgcc      180

gggcccccuc aaucucccca gggagcuagc gcccugccua ccacaaucuc cuucaccugu      240

uggagacagc cgaacgaggg cucuagcucc caggaagagg aagggcccag cacaucuccu      300

gacgcggagu cccucuuucg ggaagcccug agcaauaagg ucgaugagcu ugcucauuuc      360

cugcuccgca aauacagagc caaggagcug gugaccaaag cugaaaugcu ggagcggguu      420

auuaagaacu auaagcgcug cuuucccgug aucuucggaa aagccucuga aucccucaag      480

augauuuuug gcaucgacgu caaagaggug gauccuacaa gcaauaccua cacgcugguu      540

accugucuug gccuguccua ugacgggcuc cugggaaaca aucaaauuuu ccccaagaca      600

ggccuucuga ucaucgugcu cgggaccauu gcgauggaag gagauucugc cagcgaggag      660

gaaaucuggg aggaacuggg cgucaugggg guguacgacg gaagagagca cacaguguau      720

ggcgaaccgc ggaaacugcu cacccaggau uggguccagg agaacuaccu ggaguaucgc      780

cagguuccug gcuccaaucc cgcuagauac gaauuucuuu gggggccucg ggcccuggcu      840

gagacgagcu acgugaaggu gcucgaacau gucgugcgcg uuaacgccag agugcggauu      900

gccuaucccu cucugcgcga ggcugcgcuu cuggaggaag aggaaggagu cuga            954


<210>  2253
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__A8K072

<400>  2253

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Leu Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ile Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  2254
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__BAF82126

<400>  2254
augccucuug agcagaggag ucagcacugc aagccugaag aaggccuuga ggcccgagga       60

gaggcccugg gccugguggg ugcgcaggcu ccugcuacug aggagcagga ggcugccucc      120

uccucuucua cucuaguuga agucacccug ggggaggugc cugcugccga gucaccagau      180

ccuccccaga guccucaggg agccuccagc cuccccacua ccaugaacua cccucucugg      240

agccaauccu augaggacuc cagcaaccaa gaagaggagg ggccaagcac cuucccugac      300

cuggagucug aguuccaagc agcacucagu aggaagcugg ccaaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccgguc acaaaggcag aaaugcuggg gagugucguc      420

ggaaauuggc aguacuucuu uccugugauc uucagcaaag cuuccgauuc cuugcagcug      480

gucuuuggca ucgagcugau ggaaguggac cccaucggcc acguguacau cuuugccacc      540

ugccugggcc ucuccuacga uggccugcug ggugacaauc agaucaugcc caagacaggc      600

uuccugauaa ucauccuggc cauaaucgca aaagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugagugu guuagaggug uuugagggga gggaagacau uaucuucggg      720

gaucccaaga agcugcucac ccaauauuuc gugcaggaaa acuaccugga guaccggcag      780

guccccggca gugauccugc augcuaugag uuccuguggg guccaagggc ccucauugaa      840

accagcuaug ugaaaguccu gcaccauaug guaaagauca guggaggacc ucgcauuucc      900

uacccacucc ugcaugagug ggcuuugaga gagggggaag aguga                      945


<210>  2255
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A6__Homo_sapiens__BAF82126

<400>  2255
augccccugg agcagcgcag ccagcacugc aagccggagg agggccucga ggcccgcggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagga ggccgccucc      120

agcuccagca cccucgucga ggugacgcug ggcgaggugc ccgcggccga gucccccgac      180

ccgccccaga gcccccaggg ggccuccagc cugcccacca ccaugaacua cccgcucugg      240

ucccagagcu acgaggacuc cagcaaccag gaggaggagg gccccuccac cuuccccgac      300

cuggagagcg aguuccaggc cgcgcugucc cggaagcucg ccaagcuggu ccacuuccug      360

cuccugaagu accgggcccg cgagcccgug acgaaggccg agaugcuggg cagcgugguc      420

gggaacuggc aguacuucuu cccggugauc uucuccaagg ccagcgacuc ccuccagcug      480

guguucggca ucgagcugau ggaggucgac cccaucgggc acguguacau cuucgcgacc      540

ugccucggcc ugagcuacga cgggcugcuc ggcgacaacc agaucaugcc caagaccggc      600

uuccugauca ucauccuggc caucaucgcc aaggaggggg acugcgcccc cgaggagaag      660

aucugggagg agcucagcgu gcuggagguc uucgagggcc gggaggacau caucuucggg      720

gacccgaaga agcugcucac ccaguacuuc gugcaggaga acuaccugga guaccgccag      780

gugcccggcu ccgaccccgc cugcuacgag uuccuguggg gcccccgggc gcucaucgag      840

acgagcuacg ucaaggugcu gcaccacaug gugaagaucu ccgggggccc gcgcaucagc      900

uacccccugc uccacgagug ggcccugcgg gagggggagg aguga                      945


<210>  2256
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A6__Homo_sapiens__BAF82126

<400>  2256
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccgcggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagga ggccgccucc      120

uccuccucca cccucgucga ggucacccuc ggcgaggucc ccgccgccga gucccccgac      180

cccccccagu ccccccaggg cgccuccucc cuccccacca ccaugaacua cccccucugg      240

ucccaguccu acgaggacuc cuccaaccag gaggaggagg gccccuccac cuuccccgac      300

cucgaguccg aguuccaggc cgcccucucc cgcaagcucg ccaagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccguc accaaggccg agaugcucgg cuccgucguc      420

ggcaacuggc aguacuucuu ccccgucauc uucuccaagg ccuccgacuc ccuccagcuc      480

gucuucggca ucgagcucau ggaggucgac cccaucggcc acgucuacau cuucgccacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc agaucaugcc caagaccggc      600

uuccucauca ucauccucgc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccgu ccucgagguc uucgagggcc gcgaggacau caucuucggc      720

gaccccaaga agcuccucac ccaguacuuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucaucgag      840

accuccuacg ucaagguccu ccaccacaug gucaagaucu ccggcggccc ccgcaucucc      900

uacccccucc uccacgagug ggcccuccgc gagggcgagg aguga                      945


<210>  2257
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A6__Homo_sapiens__BAF82126

<400>  2257
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agccagggga       60

gaggcucuug ggcugguggg ugcacaggcc ccagcgaccg aagaacagga ggcugccucc      120

ucuucaagua cauuggucga aguuacuuua ggcgaggugc cggcagccga aagccccgac      180

ccuccacaga guccccaagg ggcuucuucg cugccuacga ccaugaacua cccacuaugg      240

ucacagagcu augaggauag uuccaaucag gaggaagagg gacccucuac auucccugac      300

cucgaaagcg aguuucaggc agcccugucc cggaaacuug cuaagcuggu acauuucuug      360

cuccugaaau accgcgcccg agaaccagug acuaaggcgg agaugcuggg cucagucgug      420

gguaacuggc aauauuucuu cccgguuauc uuuaguaaag caagcgauuc ucuccaguua      480

guguucggga uugagcugau ggaagucgac cccauaggac acguguacau cuuugccacc      540

ugucuuggcu uguccuauga uggccugcua ggggacaauc agauuaugcc uaagacagga      600

uuccucauca uuauccuggc uauaaucgcc aaggagggug auugcgcacc agaagagaaa      660

auuugggagg agcuuucagu acuggagguu uuugaaggcc gugaggacau cauuuucggg      720

gaucccaaga aauugcucac ccaguacuuu gugcaagaaa acuaucugga guacagacag      780

gucccuggaa gcgacccagc uuguuacgaa uuuuuauggg gccccagggc ccugaucgag      840

acuuccuaug ugaaggugcu ccaucacaug gucaaaauau cuggugggcc gcggauuucc      900

uacccucuuc ugcaugagug ggcguugcgc gaaggagagg aauga                      945


<210>  2258
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A6__Homo_sapiens__BAF82126

<400>  2258
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggccagaggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagga ggccgccagc      120

agcagcagca cccuggugga ggugacccug ggcgaggugc ccgccgccga gagccccgac      180

cccccccaga gcccccaggg cgccagcagc cugcccacca ccaugaacua cccccugugg      240

agccagagcu acgaggacag cagcaaccag gaggaggagg gccccagcac cuuccccgac      300

cuggagagcg aguuccaggc cgcccugagc agaaagcugg ccaagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccgug accaaggccg agaugcuggg cagcguggug      420

ggcaacuggc aguacuucuu ccccgugauc uucagcaagg ccagcgacag ccugcagcug      480

guguucggca ucgagcugau ggagguggac cccaucggcc acguguacau cuucgccacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc agaucaugcc caagaccggc      600

uuccugauca ucauccuggc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu gcuggaggug uucgagggca gagaggacau caucuucggc      720

gaccccaaga agcugcugac ccaguacuuc gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugaucgag      840

accagcuacg ugaaggugcu gcaccacaug gugaagauca gcggcggccc cagaaucagc      900

uacccccugc ugcacgagug ggcccugaga gagggcgagg aguga                      945


<210>  2259
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A6__Homo_sapiens__BAF82126

<400>  2259
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccgcggg       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aagaacagga ggccgccucc      120

ucuagcucca cacuggucga aguuacgcuc ggggaggugc ccgcugccga aucuccugau      180

cccccucaga gcccccaagg agcuuccucu cugccuacca caaugaacua cccgcuuugg      240

agccaguccu augaggacag cucuaaucag gaggaagagg gccccuccac cuucccugac      300

cuggaaagcg aguuucaggc cgcgcucucu cggaaacugg ccaagcuggu gcauuuccuc      360

cugcuuaaau acagagcucg ggaacccguc acaaaggccg agaugcuggg guccgugguu      420

ggaaacuggc aauauuucuu cccugugauc uuuagcaagg cuucugauuc ccuccagcug      480

gucuucggca uugagcuuau ggaaguggac cccaucggcc acguuuacau uuuugccacc      540

ugucuggggc ucagcuauga uggacugcug ggcgacaauc agaucaugcc gaaaacaggg      600

uuccucauua ucauccuggc gauuaucgcc aaggagggag auugcgcucc ugaagagaaa      660

auuugggagg agcuuuccgu gcuggagguc uuugaaggcc gcgaggacau cauuuucggg      720

gaucccaaga aacuccugac ccaguacuuu gugcaagaaa acuaucuuga guacagacag      780

gugccuggau cugaccccgc cuguuacgaa uuucuguggg gcccccgggc ucucaucgag      840

acgagcuaug ucaagguucu gcaucacaug gugaaaauuu ccggcgggcc ucgcaucagc      900

uacccgcugc uccaugagug ggcccugaga gaaggagagg aauga                      945


<210>  2260
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__P43360

<400>  2260

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  2261
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__AAA19006

<400>  2261
augccucuug agcagaggag ucagcacugc aagccugaag aaggccuuga ggcccgagga       60

gaggcccugg gccugguggg ugcgcaggcu ccugcuacug aggagcagga ggcugccucc      120

uccucuucua cucuaguuga agucacccug ggggaggugc cugcugccga gucaccagau      180

ccuccccaga guccucaggg agccuccagc cuccccacua ccaugaacua cccucucugg      240

agccaauccu augaggacuc cagcaaccaa gaagaggagg ggccaagcac cuucccugac      300

cuggagucug aguuccaagc agcacucagu aggaaggugg ccaaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccgguc acaaaggcag aaaugcuggg gagugucguc      420

ggaaauuggc aguacuucuu uccugugauc uucagcaaag cuuccgauuc cuugcagcug      480

gucuuuggca ucgagcugau ggaaguggac cccaucggcc acguguacau cuuugccacc      540

ugccugggcc ucuccuacga uggccugcug ggugacaauc agaucaugcc caagacaggc      600

uuccugauaa ucauccuggc cauaaucgca aaagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugagugu guuagaggug uuugagggga gggaagacag uaucuucggg      720

gaucccaaga agcugcucac ccaauauuuc gugcaggaaa acuaccugga guaccggcag      780

guccccggca gugauccugc augcuaugag uuccuguggg guccaagggc ccucauugaa      840

accagcuaug ugaaaguccu gcaccauaug guaaagauca guggaggacc ucgcauuucc      900

uacccacucc ugcaugagug ggcuuugaga gagggggaag aguga                      945


<210>  2262
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A6__Homo_sapiens__AAA19006

<400>  2262
augccccugg agcagcgcag ccagcacugc aagccggagg agggccucga ggcccgcggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagga ggccgccucc      120

agcuccagca cccucgucga ggugacgcug ggcgaggugc ccgcggccga gucccccgac      180

ccgccccaga gcccccaggg ggccuccagc cugcccacca ccaugaacua cccgcucugg      240

ucccagagcu acgaggacuc cagcaaccag gaggaggagg gccccuccac cuuccccgac      300

cuggagagcg aguuccaggc cgcgcugucc cggaaggucg ccaagcucgu gcacuuccug      360

cugcucaagu accgggcccg cgagcccgug acgaaggccg agaugcuggg cagcgucgug      420

gggaacuggc aguacuucuu cccggugauc uucuccaagg ccagcgacuc ccugcagcuc      480

gucuucggca ucgagcugau ggagguggac cccaucgggc acguguacau cuucgcgacc      540

ugccugggcc ucagcuacga cgggcugcug ggcgacaacc agaucaugcc caagaccggc      600

uuccucauca ucauccuggc caucaucgcc aaggaggggg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu ccucgaggug uucgagggcc gggaggacuc caucuucggg      720

gacccgaaga agcugcugac ccaguacuuc gugcaggaga acuaccucga guaccgccag      780

guccccggca gcgaccccgc cugcuacgag uuccuguggg gcccccgggc gcugaucgag      840

acguccuacg ugaaggugcu ccaccacaug gucaagauca gcgggggccc gcgcaucucc      900

uacccccugc ugcacgagug ggcccuccgg gagggggagg aguga                      945


<210>  2263
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A6__Homo_sapiens__AAA19006

<400>  2263
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccgcggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagga ggccgccucc      120

uccuccucca cccucgucga ggucacccuc ggcgaggucc ccgccgccga gucccccgac      180

cccccccagu ccccccaggg cgccuccucc cuccccacca ccaugaacua cccccucugg      240

ucccaguccu acgaggacuc cuccaaccag gaggaggagg gccccuccac cuuccccgac      300

cucgaguccg aguuccaggc cgcccucucc cgcaaggucg ccaagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccguc accaaggccg agaugcucgg cuccgucguc      420

ggcaacuggc aguacuucuu ccccgucauc uucuccaagg ccuccgacuc ccuccagcuc      480

gucuucggca ucgagcucau ggaggucgac cccaucggcc acgucuacau cuucgccacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc agaucaugcc caagaccggc      600

uuccucauca ucauccucgc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccgu ccucgagguc uucgagggcc gcgaggacuc caucuucggc      720

gaccccaaga agcuccucac ccaguacuuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucaucgag      840

accuccuacg ucaagguccu ccaccacaug gucaagaucu ccggcggccc ccgcaucucc      900

uacccccucc uccacgagug ggcccuccgc gagggcgagg aguga                      945


<210>  2264
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A6__Homo_sapiens__AAA19006

<400>  2264
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agccagggga       60

gaggcucuug ggcugguggg ugcacaggcc ccagcgaccg aagaacagga ggcugccucc      120

ucuucaagua cauuggucga aguuacuuua ggcgaggugc cggcagccga aagccccgac      180

ccuccacagu cuccccaagg ggcuuccucg cugccuacga ccaugaacua cccacuaugg      240

ucacagagcu augaggauag uuccaaucag gaggaagagg gacccucuac auucccugac      300

cucgaaagcg aguuucaggc agcccugucc cggaaaguag cuaaacuugu gcauuuccug      360

uugcucaagu accgcgcccg agaaccaguc acuaaggcgg agaugcuggg cucagugguu      420

gguaacuggc aauauuucuu cccggugauc uuuaguaaag caagcgauuc ucugcagcuc      480

gucuucggga uugaguuaau ggaaguggac cccauaggac acguauacau cuuugccacc      540

ugucugggcc uuuccuauga uggcuugcug ggggacaauc agauuaugcc uaagacagga      600

uuccuaauca uuauccucgc uauaaucgcc aaggagggug auugcgcacc agaagagaaa      660

auuugggagg agcugucagu ucuugaggug uuugaaggcc gugaggacag caucuucggg      720

gaucccaaga aacuguugac ccaguacuuu guccaagaaa acuaucucga guacagacag      780

gugccuggaa gugacccagc uuguuacgaa uuucuguggg gccccagggc cuuaauugag      840

acuucuuaug ugaagguccu gcaucacaug guuaaaaucu ccggugggcc gcggauaagc      900

uacccucucc uucaugagug ggcgcugcgc gaaggagagg aauga                      945


<210>  2265
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A6__Homo_sapiens__AAA19006

<400>  2265
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggccagaggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagga ggccgccagc      120

agcagcagca cccuggugga ggugacccug ggcgaggugc ccgccgccga gagccccgac      180

cccccccaga gcccccaggg cgccagcagc cugcccacca ccaugaacua cccccugugg      240

agccagagcu acgaggacag cagcaaccag gaggaggagg gccccagcac cuuccccgac      300

cuggagagcg aguuccaggc cgcccugagc agaaaggugg ccaagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccgug accaaggccg agaugcuggg cagcguggug      420

ggcaacuggc aguacuucuu ccccgugauc uucagcaagg ccagcgacag ccugcagcug      480

guguucggca ucgagcugau ggagguggac cccaucggcc acguguacau cuucgccacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc agaucaugcc caagaccggc      600

uuccugauca ucauccuggc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu gcuggaggug uucgagggca gagaggacag caucuucggc      720

gaccccaaga agcugcugac ccaguacuuc gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugaucgag      840

accagcuacg ugaaggugcu gcaccacaug gugaagauca gcggcggccc cagaaucagc      900

uacccccugc ugcacgagug ggcccugaga gagggcgagg aguga                      945


<210>  2266
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A6__Homo_sapiens__AAA19006

<400>  2266
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccgcggg       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aagaacagga ggccgccucc      120

ucuagcucca cacuggucga aguuacgcuc ggggaggugc ccgcugccga aucuccugau      180

cccccucaga gcccccaagg agcuuccucu cugccuacca caaugaacua cccgcuuugg      240

agccaguccu augaggacag cucuaaucag gaggaagagg gccccuccac cuucccugac      300

cuggaaagcg aguuucaggc cgcgcucucu cggaaagugg ccaagcuggu ccauuuccug      360

cuccugaaau acagagcucg ggaacccgug acaaaggccg agaugcuugg guccguugug      420

ggaaacuggc aauauuucuu cccugucauc uuuagcaagg cuucugauuc ccugcagcuc      480

guguucggca uugagcugau ggaaguugac cccaucggcc acguguacau uuuugccacc      540

ugucuugggc ugagcuauga uggacuccug ggcgacaauc agaucaugcc gaaaacaggg      600

uuccugauua ucauccucgc gauuaucgcc aaggagggag auugcgcucc ugaagagaaa      660

auuugggagg agcuguccgu ccuugaggug uuugaaggcc gcgaggacuc uaucuucggg      720

gaucccaaga aacugcucac ccaguacuuu gugcaagaaa acuaucugga guacagacag      780

gucccuggaa gcgaccccgc cuguuacgaa uuucuuuggg gcccccgggc ucugauugag      840

acguccuaug uuaaggugcu ccaucacaug gugaaaauca gcggcgggcc ucgcauuucu      900

uacccgcugc ugcaugagug ggcccucaga gaaggagagg aauga                      945


<210>  2267
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__Q6FHI5

<400>  2267

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Phe Arg Glu Gly Glu Glu 
305                 310                 


<210>  2268
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A6__Homo_sapiens__CAG46567

<400>  2268
augccacuug agcagaggag ucagcacugc aagccugaag aaggccuuga ggcccgagga       60

gaggcccugg gccugguggg ugcgcaggcu ccugcuacug aggagcagga ggcugccucc      120

uccucuucua cucuaguuga agucacccug ggggaggugc cugcugccga gucaccagau      180

ccuccccaga guccucaggg agccuccagc cuccccacua ccaugaacua cccucucugg      240

agccaauccu augaggacuc cagcaaccaa gaagaggagg ggccaagcac cuucccugac      300

cuggagucug aguuccaagc agcacucagu aggaaggugg ccaaguuggu ucauuuucug      360

cuccucaagu aucgagccag ggagccgguc acaaaggcag aaaugcuggg gagugucguc      420

ggaaauuggc aguacuucuu uccugugauc uucagcaaag cuuccgauuc cuugcagcug      480

gucuuuggca ucgagcugau ggaaguggac cccaucggcc acguguacau cuuugccacc      540

ugccugggcc ucuccuacga uggccugcug ggugacaauc agaucaugcc caagacaggc      600

uuccugauaa ucauccuggc cauaaucgca aaagagggcg acugugcccc ugaggagaaa      660

aucugggagg agcugagugu guuagaggug uuugagggga gggaagacag uaucuucggg      720

gaucccaaga agcugcucac ccaauauuuc gugcaggaaa acuaccugga guaccggcag      780

guccccggca gugauccugc augcuaugag uuccuguggg guccaagggc ccucauugaa      840

accagcuaug ugaaaguccu gcaccauaug guaaagauca guggaggacc ucgcauuucc      900

uacccacucc ugcaugagug ggcuuuuaga gagggggaag aguga                      945


<210>  2269
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A6__Homo_sapiens__CAG46567

<400>  2269
augccccugg agcagcgcag ccagcacugc aagccggagg agggccucga ggcccgcggg       60

gaggcccugg gccugguggg ggcgcaggcc cccgccaccg aggagcagga ggccgccucc      120

agcuccagca cccucgucga ggugacgcug ggcgaggugc ccgcggccga gucccccgac      180

ccgccccaga gcccccaggg ggccuccagc cugcccacca ccaugaacua cccgcucugg      240

ucccagagcu acgaggacuc cagcaaccag gaggaggagg gccccuccac cuuccccgac      300

cuggagagcg aguuccaggc cgcgcugucc cggaaggucg ccaagcucgu gcacuuccug      360

cugcucaagu accgggcccg cgagcccgug acgaaggccg agaugcuggg cagcgucgug      420

gggaacuggc aguacuucuu cccggugauc uucuccaagg ccagcgacuc ccugcagcuc      480

gucuucggca ucgagcugau ggagguggac cccaucgggc acguguacau cuucgcgacc      540

ugccugggcc ucagcuacga cgggcugcug ggcgacaacc agaucaugcc caagaccggc      600

uuccucauca ucauccuggc caucaucgcc aaggaggggg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu ccucgaggug uucgagggcc gggaggacuc caucuucggg      720

gacccgaaga agcugcugac ccaguacuuc gugcaggaga acuaccucga guaccgccag      780

guccccggca gcgaccccgc cugcuacgag uuccuguggg gcccccgggc gcugaucgag      840

acguccuacg ugaaggugcu ccaccacaug gucaagauca gcgggggccc gcgcaucucc      900

uacccccugc ugcacgagug ggccuuccgg gagggggagg aguga                      945


<210>  2270
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A6__Homo_sapiens__CAG46567

<400>  2270
augccccucg agcagcgcuc ccagcacugc aagcccgagg agggccucga ggcccgcggc       60

gaggcccucg gccucgucgg cgcccaggcc cccgccaccg aggagcagga ggccgccucc      120

uccuccucca cccucgucga ggucacccuc ggcgaggucc ccgccgccga gucccccgac      180

cccccccagu ccccccaggg cgccuccucc cuccccacca ccaugaacua cccccucugg      240

ucccaguccu acgaggacuc cuccaaccag gaggaggagg gccccuccac cuuccccgac      300

cucgaguccg aguuccaggc cgcccucucc cgcaaggucg ccaagcucgu ccacuuccuc      360

cuccucaagu accgcgcccg cgagcccguc accaaggccg agaugcucgg cuccgucguc      420

ggcaacuggc aguacuucuu ccccgucauc uucuccaagg ccuccgacuc ccuccagcuc      480

gucuucggca ucgagcucau ggaggucgac cccaucggcc acgucuacau cuucgccacc      540

ugccucggcc ucuccuacga cggccuccuc ggcgacaacc agaucaugcc caagaccggc      600

uuccucauca ucauccucgc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcucuccgu ccucgagguc uucgagggcc gcgaggacuc caucuucggc      720

gaccccaaga agcuccucac ccaguacuuc guccaggaga acuaccucga guaccgccag      780

guccccggcu ccgaccccgc cugcuacgag uuccucuggg gcccccgcgc ccucaucgag      840

accuccuacg ucaagguccu ccaccacaug gucaagaucu ccggcggccc ccgcaucucc      900

uacccccucc uccacgagug ggccuuccgc gagggcgagg aguga                      945


<210>  2271
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A6__Homo_sapiens__CAG46567

<400>  2271
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agccagggga       60

gaggcucuug ggcugguggg ugcacaggcc ccagcgaccg aagaacagga ggcugccucc      120

ucuucaagua cauuggucga aguuacuuua ggcgaggugc cggcagccga aagccccgac      180

ccuccacagu cuccccaagg ggcuuccucg cugccuacga ccaugaacua cccacuaugg      240

ucacagagcu augaggauag uuccaaucag gaggaagagg gacccucuac auucccugac      300

cucgaaagcg aguuucaggc agcccugucc cggaaaguag cuaaacuugu gcauuuccug      360

uugcucaagu accgcgcccg agaaccaguc acuaaggcgg agaugcuggg cucagugguu      420

gguaacuggc aauauuucuu cccggugauc uuuaguaaag caagcgauuc ucugcagcuc      480

gucuucggga uugaguuaau ggaaguggac cccauaggac acguauacau cuuugccacc      540

ugucugggcc uuuccuauga uggcuugcug ggggacaauc agauuaugcc uaagacagga      600

uuccuaauca uuauccucgc uauaaucgcc aaggagggug auugcgcacc agaagagaaa      660

auuugggagg agcugucagu ucuugaggug uuugaaggcc gugaggacag caucuucggg      720

gaucccaaga aacuguugac ccaguacuuu guccaagaaa acuaucucga guacagacag      780

gugccuggaa gugacccagc uuguuacgaa uuucuguggg gccccagggc cuuaauugag      840

acuucuuaug ugaagguccu gcaucacaug guuaaaaucu ccggugggcc gcggauaagc      900

uacccucucc uucaugagug ggcguuucgc gaaggagagg aauga                      945


<210>  2272
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A6__Homo_sapiens__CAG46567

<400>  2272
augccccugg agcagagaag ccagcacugc aagcccgagg agggccugga ggccagaggc       60

gaggcccugg gccugguggg cgcccaggcc cccgccaccg aggagcagga ggccgccagc      120

agcagcagca cccuggugga ggugacccug ggcgaggugc ccgccgccga gagccccgac      180

cccccccaga gcccccaggg cgccagcagc cugcccacca ccaugaacua cccccugugg      240

agccagagcu acgaggacag cagcaaccag gaggaggagg gccccagcac cuuccccgac      300

cuggagagcg aguuccaggc cgcccugagc agaaaggugg ccaagcuggu gcacuuccug      360

cugcugaagu acagagccag agagcccgug accaaggccg agaugcuggg cagcguggug      420

ggcaacuggc aguacuucuu ccccgugauc uucagcaagg ccagcgacag ccugcagcug      480

guguucggca ucgagcugau ggagguggac cccaucggcc acguguacau cuucgccacc      540

ugccugggcc ugagcuacga cggccugcug ggcgacaacc agaucaugcc caagaccggc      600

uuccugauca ucauccuggc caucaucgcc aaggagggcg acugcgcccc cgaggagaag      660

aucugggagg agcugagcgu gcuggaggug uucgagggca gagaggacag caucuucggc      720

gaccccaaga agcugcugac ccaguacuuc gugcaggaga acuaccugga guacagacag      780

gugcccggca gcgaccccgc cugcuacgag uuccuguggg gccccagagc ccugaucgag      840

accagcuacg ugaaggugcu gcaccacaug gugaagauca gcggcggccc cagaaucagc      900

uacccccugc ugcacgagug ggccuucaga gagggcgagg aguga                      945


<210>  2273
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A6__Homo_sapiens__CAG46567

<400>  2273
augccccugg agcagagaag ccaacacugc aagccugaag agggccucga agcccgcggg       60

gaggcucugg gacuuguggg cgcccaggcg ccggcuaccg aagaacagga ggccgccucc      120

ucuagcucca cacuggucga aguuacgcuc ggggaggugc ccgcugccga aucuccugau      180

cccccucaga gcccccaagg agcuuccucu cugccuacca caaugaacua cccgcuuugg      240

agccaguccu augaggacag cucuaaucag gaggaagagg gccccuccac cuucccugac      300

cuggaaagcg aguuucaggc cgcgcucucu cggaaagugg ccaagcuggu ccauuuccug      360

cuccugaaau acagagcucg ggaacccgug acaaaggccg agaugcuugg guccguugug      420

ggaaacuggc aauauuucuu cccugucauc uuuagcaagg cuucugauuc ccugcagcuc      480

guguucggca uugagcugau ggaaguugac cccaucggcc acguguacau uuuugccacc      540

ugucuugggc ugagcuauga uggacuccug ggcgacaauc agaucaugcc gaaaacaggg      600

uuccugauua ucauccucgc gauuaucgcc aaggagggag auugcgcucc ugaagagaaa      660

auuugggagg agcuguccgu ccuugaggug uuugaaggcc gcgaggacuc uaucuucggg      720

gaucccaaga aacugcucac ccaguacuuu gugcaagaaa acuaucugga guacagacag      780

gucccuggaa gcgaccccgc cuguuacgaa uuucuuuggg gcccccgggc ucugauugag      840

acguccuaug uuaaggugcu ccaucacaug gugaaaauca gcggcgggcc ucgcauuucu      900

uacccgcugc ugcaugagug ggccuuuaga gaaggagagg aauga                      945


<210>  2274
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-A9__Homo_sapiens__P43362

<400>  2274

Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu 
1               5                   10                  15      


Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr 
            20                  25                  30          


Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu 
        35                  40                  45              


Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly 
    50                  55                  60                  


Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp 
65                  70                  75                  80  


Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp 
                85                  90                  95      


Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val 
            100                 105                 110         


Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro 
        115                 120                 125             


Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg 
    130                 135                 140                 


Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile 
145                 150                 155                 160 


Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile 
                165                 170                 175     


Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly 
            180                 185                 190         


His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile 
        195                 200                 205             


Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu 
    210                 215                 220                 


Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu 
225                 230                 235                 240 


Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu 
                245                 250                 255     


Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp 
            260                 265                 270         


Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr 
        275                 280                 285             


Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr 
    290                 295                 300                 


Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val 
305                 310                 315 


<210>  2275
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-A9__Homo_sapiens__AAA68877

<400>  2275
augucucucg agcagaggag uccgcacugc aagccugaug aagaccuuga agcccaagga       60

gaggacuugg gccugauggg ugcacaggaa cccacaggcg aggaggagga gacuaccucc      120

uccucugaca gcaaggagga ggaggugucu gcugcugggu caucaagucc uccccagagu      180

ccucagggag gcgcuuccuc cuccauuucc gucuacuaca cuuuauggag ccaauucgau      240

gagggcucca gcagucaaga agaggaagag ccaagcuccu cggucgaccc agcucagcug      300

gaguucaugu uccaagaagc acugaaauug aagguggcug aguugguuca uuuccugcuc      360

cacaaauauc gagucaagga gccggucaca aaggcagaaa ugcuggagag cgucaucaaa      420

aauuacaagc gcuacuuucc ugugaucuuc ggcaaagccu ccgaguucau gcaggugauc      480

uuuggcacug augugaagga gguggacccc gccggccacu ccuacauccu ugucacugcu      540

cuuggccucu cgugcgauag caugcugggu gauggucaua gcaugcccaa ggccgcccuc      600

cugaucauug uccugggugu gauccuaacc aaagacaacu gcgccccuga agagguuauc      660

ugggaagcgu ugagugugau ggggguguau guugggaagg agcacauguu cuacggggag      720

cccaggaagc ugcucaccca agauugggug caggaaaacu accuggagua ccggcaggug      780

cccggcagug auccugcgca cuacgaguuc cugugggguu ccaaggccca cgcugaaacc      840

agcuaugaga aggucauaaa uuauuugguc augcucaaug caagagagcc caucugcuac      900

ccaucccuuu augaagaggu uuugggagag gagcaagagg gagucuga                   948


<210>  2276
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-A9__Homo_sapiens__AAA68877

<400>  2276
augagccugg agcagcgcag cccccacugc aagccggacg aggaccucga ggcccagggc       60

gaggaccugg ggcugauggg cgcccaggag cccaccgggg aggaggagga gaccacgucc      120

uccagcgacu ccaaggagga ggaggugagc gcggccggcu ccagcucccc gccccagagc      180

ccccagggcg gggccuccag cuccaucagc gucuacuaca cccucugguc ccaguucgac      240

gagggcagcu ccagccagga ggaggaggag cccuccagca gcguggaccc cgcccagcug      300

gaguucaugu uccaggaggc ccugaagcuc aagguggcgg agcuggucca cuuccugcuc      360

cacaaguacc gggugaagga gcccgugacc aaggccgaga ugcuggaguc cgucaucaag      420

aacuacaagc gcuacuuccc ggugaucuuc gggaaggcca gcgaguucau gcaggucauc      480

uucggcaccg acgugaagga gguggacccc gccgggcacu ccuacauccu ggugacggcg      540

cucggccuga gcugcgacuc caugcugggg gacggccaca gcaugcccaa ggccgcccuc      600

cugaucaucg uccugggcgu gauccucacc aaggacaacu gcgcccccga ggaggugauc      660

ugggaggccc uguccgucau ggggguguac gugggcaagg agcacauguu cuacggggag      720

ccgcggaagc ugcucaccca ggacuggguc caggagaacu accuggagua ccgccaggug      780

cccggcagcg accccgcgca cuacgaguuc cuguggggcu ccaaggccca cgccgagacc      840

agcuacgaga aggugaucaa cuaccucguc augcugaacg cccgggagcc caucugcuac      900

ccgucccugu acgaggaggu gcucggggag gagcaggagg gcguguga                   948


<210>  2277
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-A9__Homo_sapiens__AAA68877

<400>  2277
augucccucg agcagcgcuc cccccacugc aagcccgacg aggaccucga ggcccagggc       60

gaggaccucg gccucauggg cgcccaggag cccaccggcg aggaggagga gaccaccucc      120

uccuccgacu ccaaggagga ggaggucucc gccgccggcu ccuccucccc cccccagucc      180

ccccagggcg gcgccuccuc cuccaucucc gucuacuaca cccucugguc ccaguucgac      240

gagggcuccu ccucccagga ggaggaggag cccuccuccu ccgucgaccc cgcccagcuc      300

gaguucaugu uccaggaggc ccucaagcuc aaggucgccg agcucgucca cuuccuccuc      360

cacaaguacc gcgucaagga gcccgucacc aaggccgaga ugcucgaguc cgucaucaag      420

aacuacaagc gcuacuuccc cgucaucuuc ggcaaggccu ccgaguucau gcaggucauc      480

uucggcaccg acgucaagga ggucgacccc gccggccacu ccuacauccu cgucaccgcc      540

cucggccucu ccugcgacuc caugcucggc gacggccacu ccaugcccaa ggccgcccuc      600

cucaucaucg uccucggcgu cauccucacc aaggacaacu gcgcccccga ggaggucauc      660

ugggaggccc ucuccgucau gggcgucuac gucggcaagg agcacauguu cuacggcgag      720

ccccgcaagc uccucaccca ggacuggguc caggagaacu accucgagua ccgccagguc      780

cccggcuccg accccgccca cuacgaguuc cucuggggcu ccaaggccca cgccgagacc      840

uccuacgaga aggucaucaa cuaccucguc augcucaacg cccgcgagcc caucugcuac      900

cccucccucu acgaggaggu ccucggcgag gagcaggagg gcgucuga                   948


<210>  2278
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-A9__Homo_sapiens__AAA68877

<400>  2278
augagccugg agcagagauc uccccacugc aagccugacg aagaucucga ggcccaaggc       60

gaagaccuug ggcugauggg agcucaggag ccaaccggug aagaggagga aacaacuucc      120

ucaagugaua gcaaagagga agaggugucc gcagccgggu cuucgucacc gccccagagc      180

ccucagggcg gagcgaguuc cucuaucagc gucuacuaua cguugugguc ccaauucgac      240

gagggcucaa guagccagga agaggaggaa ccaucuuccu caguugaucc cgcucaguua      300

gaauuuaugu uccaggaggc ccugaagcua aaaguggcag agcucguaca uuuucugcuu      360

cacaaguaca gggugaaaga accugucacc aaggccgaga ugcuggaaag cgugauuaag      420

aacuauaaac gguacuuccc aguuauauuu gguaaggcua gugaguucau gcaagugauc      480

uuugggacag acgucaaaga aguggauccc gcaggacauu cuuauauuuu gguaacugcc      540

cucggccugu ccugugacag caugcugggc gaugggcacu cgaugccuaa ggcugcccuc      600

uuaaucauug uucugggagu gauccuuacc aaagacaauu gcgcgccaga ggaggucaua      660

ugggaagcau ugucugugau ggguguguac gucggcaagg agcauauguu cuauggggaa      720

ccgcgcaagc ugcuaacaca ggauuggguu caggagaacu accucgaaua ccgacaggug      780

cccggauccg acccugccca cuaugaguuu cuguggggcu caaaagcuca cgccgagacc      840

aguuacgaaa agguaaucaa uuaucuugug augcugaacg cacgugagcc aauuuguuac      900

cccagcuugu augaagaggu ccucggugag gaacaagagg ggguguga                   948


<210>  2279
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-A9__Homo_sapiens__AAA68877

<400>  2279
augagccugg agcagagaag cccccacugc aagcccgacg aggaccugga ggcccagggc       60

gaggaccugg gccugauggg cgcccaggag cccaccggcg aggaggagga gaccaccagc      120

agcagcgaca gcaaggagga ggaggugagc gccgccggca gcagcagccc cccccagagc      180

ccccagggcg gcgccagcag cagcaucagc guguacuaca cccuguggag ccaguucgac      240

gagggcagca gcagccagga ggaggaggag cccagcagca gcguggaccc cgcccagcug      300

gaguucaugu uccaggaggc ccugaagcug aagguggccg agcuggugca cuuccugcug      360

cacaaguaca gagugaagga gcccgugacc aaggccgaga ugcuggagag cgugaucaag      420

aacuacaaga gauacuuccc cgugaucuuc ggcaaggcca gcgaguucau gcaggugauc      480

uucggcaccg acgugaagga gguggacccc gccggccaca gcuacauccu ggugaccgcc      540

cugggccuga gcugcgacag caugcugggc gacggccaca gcaugcccaa ggccgcccug      600

cugaucaucg ugcugggcgu gauccugacc aaggacaacu gcgcccccga ggaggugauc      660

ugggaggccc ugagcgugau gggcguguac gugggcaagg agcacauguu cuacggcgag      720

cccagaaagc ugcugaccca ggacugggug caggagaacu accuggagua cagacaggug      780

cccggcagcg accccgccca cuacgaguuc cuguggggca gcaaggccca cgccgagacc      840

agcuacgaga aggugaucaa cuaccuggug augcugaacg ccagagagcc caucugcuac      900

cccagccugu acgaggaggu gcugggcgag gagcaggagg gcguguga                   948


<210>  2280
<211>  948
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-A9__Homo_sapiens__AAA68877

<400>  2280
augagccugg agcagagaag cccccacugc aagccugacg aagaucucga ggcccaaggc       60

gaagaccugg ggcuuauggg agcucaggag ccgaccggcg aagaggagga aacaacgucu      120

agcuccgauu cuaaagagga agaggugagc gccgcggggu ccucuagccc uccccagucu      180

ccccagggag gcgcuuccuc cuccaucagc gucuacuaua cccugugguc ucaauucgac      240

gaggggucca gcucucagga agaggaggaa ccuuccagcu ccguugaucc cgcccagcuc      300

gaauuuaugu uccaggaggc ccugaaacuu aagguggcug agcuggugca uuuucuccug      360

cacaaguacc gggucaaaga accugugaca aaggccgaga ugcuggaauc uguuauuaag      420

aacuauaaac gcuacuuccc ggugaucuuu ggaaaggcua gcgaguucau gcaagucauu      480

uuuggcaccg acgugaaaga aguugauccc gccggccauu ccuauauccu cgugacagcg      540

cuggggcuua gcugugacuc uaugcuggga gauggccacu ccaugccuaa ggccgcucuc      600

cugauuaucg uccuuggggu gauccugacc aaagacaauu gcgcccccga ggaggugauu      660

ugggaagcuc ucagcgucau gggaguuuac gugggcaagg agcauauguu cuauggggaa      720

ccuagaaagc ugcugacaca ggauugggug caggagaacu accucgaaua ccggcagguc      780

cccggaucug acccggccca cuaugaguuu cuguggggca gcaaagcgca cgccgagacc      840

uccuacgaaa aggugaucaa uuaucuuguu augcugaacg cucgcgagcc uauuuguuac      900

cccucucucu augaagaggu gcugggcgag gaacaagagg gggucuga                   948


<210>  2281
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B10__Homo_sapiens__Q96LZ2

<400>  2281

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Gln Ala Arg Gly Gly Leu Glu Asp Leu Ile Asp Ala Leu Asp Ile Leu 
            20                  25                  30          


Glu Glu Glu Glu Glu Ser Pro Pro Ser Ala Ser Ala Cys Leu Lys Asp 
        35                  40                  45              


Val Phe Gln Ser Ser Leu Asp Gly Ala Ser Asn Asn Pro His Gly Leu 
    50                  55                  60                  


Arg Glu Ala Gln Ser Thr Ser Thr Ser Ala Thr Ala Ala Ser His Thr 
65                  70                  75                  80  


Arg His Pro Glu Gly Val Asn Asp Gln Met Glu Glu Arg Pro Ile Cys 
                85                  90                  95      


Thr Gln Asp Leu Glu Ala Thr Asp Ser Phe Pro Arg Gly Pro Val Asp 
            100                 105                 110         


Glu Lys Val Ile Ile Leu Val His Tyr Leu Leu Tyr Lys Tyr Gln Met 
        115                 120                 125             


Lys Glu Pro Ile Thr Lys Ala Asp Met Leu Arg Asn Val Thr Gln Met 
    130                 135                 140                 


Ser Lys Ser Gln Phe Pro Val Ile Leu Ser Arg Ala Ser Glu His Leu 
145                 150                 155                 160 


Glu Leu Ile Phe Gly Leu Asp Leu Lys Glu Val Glu Pro Asn Lys His 
                165                 170                 175     


Ile Tyr Val Leu Val Asn Lys Leu Asp Leu Gly Cys Asp Ala Lys Leu 
            180                 185                 190         


Ser Asp Glu Thr Gly Val Pro Lys Thr Gly Leu Leu Met Thr Val Leu 
        195                 200                 205             


Gly Ile Ile Phe Thr Asn Gly Asn Cys Val Ala Glu Glu Glu Val Trp 
    210                 215                 220                 


Lys Val Phe Asn Thr Met Gly Leu Tyr Asp Gly Ile Glu His Phe Met 
225                 230                 235                 240 


Phe Gly Glu Pro Arg Lys Leu Leu Thr Lys Asp Leu Val Lys Glu Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Gln Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln 
            260                 265                 270         


Phe Leu Trp Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val 
        275                 280                 285             


Leu Glu Phe Leu Ala Lys Val Asn Asp Thr Ala Pro Ser Glu Phe Ser 
    290                 295                 300                 


Asn Trp Tyr Thr Glu Ala Leu Gln Asp Glu Glu Glu Arg Ala Arg Ala 
305                 310                 315                 320 


Arg Val Ala Ala Lys Ala Arg Val Ser Ala Thr Ala Gly Ala Arg Ser 
                325                 330                 335     


Lys Val Lys Ser Ser Lys Ser Ser Gln Leu Gln 
            340                 345         


<210>  2282
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B10__Homo_sapiens__AAI01309

<400>  2282
augccucgag gucagaagag uaaacuccgu gccagggaaa aacgccguca ggcccgagga       60

gggcuggaag auuugauaga ugcucuggac auuuuagaag aggaggaaga aucucccccc      120

ucugccucug cuuguuugaa ggauguuuuc cagaguucac uugauggggc auccaacaau      180

ccccauggac uucgggaagc ccaauccacc agcacaucug cuacagcugc uucacacaca      240

agacaucccg aaggagucaa cgaccaaaug gaagaaaggc caauaugcac acaagaucua      300

gaagccacug auagcuuucc cagaggcccu guagaugaga aaguaauuau auuggugcau      360

uacuugcugu acaaguacca aaugaaagag cccauuacaa aggcagauau gcugagaaau      420

guaacccaaa uguccaagag ccaguucccu guaauccuga gcagagcuuc ugagcaccug      480

gagcugaucu uuggucuuga ccugaaggaa guggagccua auaagcacau cuauguccuu      540

gucaacaaac uagaucuagg cugugaugca aagcugagug augaaacagg cgugcccaag      600

acuggccugc ugaugacugu ccuggguauu aucuucacaa auggcaauug ugucgcugag      660

gaggaagucu ggaaaguguu uaacacgaug ggguuauaug acggaauuga gcacuucaug      720

uuuggggagc ccaggaagcu ccuuaccaaa gauuugguga aagaaaauua ccuggaguac      780

cagcaagugc ccaacaguga uccuccacgc uaucaauucc uauggggccc aagagcccau      840

gcugaaacca gcaagaugaa aguucuugag uuuuuggcca agguaaauga uacagcuccc      900

agugaauucu caaacuggua uacagaggcu uuacaagaug aggaagagag agccagagcc      960

agaguugcag ccaaggcucg cguuagugcc acagccggug cacguuccaa gguuaagucc     1020

agcaaguccu cccaacugca guaa                                            1044


<210>  2283
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B10__Homo_sapiens__AAI01309

<400>  2283
augccccgcg gccagaaguc caagcugcgg gcccgcgaga agcggcgcca ggcccgcggg       60

ggccucgagg accugaucga cgcgcuggac auccucgagg aggaggagga gagcccgccc      120

agcgccuccg ccugccugaa ggacguguuc cagagcuccc uggacggggc cagcaacaac      180

ccccacggcc uccgggaggc ccaguccacc agcaccuccg cgacggccgc cagccacacc      240

cggcaccccg agggggugaa cgaccagaug gaggagcgcc cgaucugcac ccaggaccug      300

gaggccaccg acuccuuccc ccggggcccc guggacgaga aggugaucau ccugguccac      360

uaccuccugu acaaguacca gaugaaggag cccaucacga aggcggacau gcugcgcaac      420

gugacccaga ugagcaaguc ccaguucccg gugauccuca gccgggccuc cgagcaccug      480

gagcugaucu ucggccucga ccugaaggag gucgagccca acaagcacau cuacgugcug      540

gugaacaagc ucgaccuggg gugcgacgcc aagcugagcg acgagaccgg cguccccaag      600

accgggcucc ugaugacggu gcugggcauc aucuucacca acgggaacug cguggccgag      660

gaggaggucu ggaagguguu caacaccaug ggccucuacg acggcaucga gcacuucaug      720

uucggggagc cccgcaagcu gcugaccaag gaccucguga aggagaacua ccuggaguac      780

cagcaggucc cgaacuccga cccgccccgg uaccaguucc uguggggccc ccgcgcccac      840

gcggagacga gcaagaugaa ggugcucgag uuccuggcca aggugaacga caccgccccc      900

uccgaguuca gcaacuggua caccgaggcc cugcaggacg aggaggagcg ggcccgcgcg      960

cgggucgccg ccaaggcccg cgugagcgcc accgcggggg cccgguccaa ggucaagagc     1020

uccaagagcu cccagcucca guga                                            1044


<210>  2284
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B10__Homo_sapiens__AAI01309

<400>  2284
augccccgcg gccagaaguc caagcuccgc gcccgcgaga agcgccgcca ggcccgcggc       60

ggccucgagg accucaucga cgcccucgac auccucgagg aggaggagga gucccccccc      120

uccgccuccg ccugccucaa ggacgucuuc caguccuccc ucgacggcgc cuccaacaac      180

ccccacggcc uccgcgaggc ccaguccacc uccaccuccg ccaccgccgc cucccacacc      240

cgccaccccg agggcgucaa cgaccagaug gaggagcgcc ccaucugcac ccaggaccuc      300

gaggccaccg acuccuuccc ccgcggcccc gucgacgaga aggucaucau ccucguccac      360

uaccuccucu acaaguacca gaugaaggag cccaucacca aggccgacau gcuccgcaac      420

gucacccaga uguccaaguc ccaguucccc gucauccucu cccgcgccuc cgagcaccuc      480

gagcucaucu ucggccucga ccucaaggag gucgagccca acaagcacau cuacguccuc      540

gucaacaagc ucgaccucgg cugcgacgcc aagcucuccg acgagaccgg cguccccaag      600

accggccucc ucaugaccgu ccucggcauc aucuucacca acggcaacug cgucgccgag      660

gaggaggucu ggaaggucuu caacaccaug ggccucuacg acggcaucga gcacuucaug      720

uucggcgagc cccgcaagcu ccucaccaag gaccucguca aggagaacua ccucgaguac      780

cagcaggucc ccaacuccga ccccccccgc uaccaguucc ucuggggccc ccgcgcccac      840

gccgagaccu ccaagaugaa gguccucgag uuccucgcca aggucaacga caccgccccc      900

uccgaguucu ccaacuggua caccgaggcc cuccaggacg aggaggagcg cgcccgcgcc      960

cgcgucgccg ccaaggcccg cgucuccgcc accgccggcg cccgcuccaa ggucaagucc     1020

uccaaguccu cccagcucca guga                                            1044


<210>  2285
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B10__Homo_sapiens__AAI01309

<400>  2285
augcccagag gccaaaagag caaacugagg gcccgggaga agcgccgaca ggcucguggg       60

ggacucgaag accuuaucga ugcacuggac auuuuggagg aagaggaaga guccccucca      120

ucugccucag cgugcuuaaa agauguguuc cagaguagcc uggacggugc uuccaacaau      180

ccgcacggcc uaagagaggc ccagucuacc ucgacaucag caacugccgc uagccauacg      240

aggcaccccg aaggggucaa cgaucagaug gaggaacggc cuauauguac ccaagaccuc      300

gaggcaacag auaguuuucc acgcggaccc guugacgaga aggugaucau ucugguacau      360

uaccuucugu auaaauacca gaugaaggaa ccuaucacua aggccgauau guugagaaau      420

gugacccaga uguccaaauc ucaguuccca gucauucuca gcagggcuuc cgagcaccug      480

gaacugaucu uuggccucga cuuaaaggag guggaaccca acaaacauau auauguucug      540

gugaauaaac uugauuuggg uugcgacgcc aagcugucag augagacagg ggucccuaag      600

accggacuac ucaugacugu gcugggcauc auuuucacaa acggcaauug uguagcggag      660

gaagagguuu ggaagguguu uaacaccaug gggcuuuacg acggaaucga acacuucaug      720

uuuggugagc cacggaaacu guugacgaag gaccucguca aagaaaauua ucuggaguac      780

caacaggugc cgaacaguga ucccccucgc uaucaguucu uauggggccc acgagcacac      840

gccgagacua gcaagaugaa agugcuggaa uuucucgcua aggucaauga caccgccccc      900

ucugaguucu ccaacuggua cacagaagca cuucaggaug aggaagagag agcuagggcc      960

cggguugcgg ccaaagcacg ugugucagcu acugccgggg cucgcagcaa gguaaagagu     1020

ucuaaaucca gccaacugca guga                                            1044


<210>  2286
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B10__Homo_sapiens__AAI01309

<400>  2286
augcccagag gccagaagag caagcugaga gccagagaga agagaagaca ggccagaggc       60

ggccuggagg accugaucga cgcccuggac auccuggagg aggaggagga gagccccccc      120

agcgccagcg ccugccugaa ggacguguuc cagagcagcc uggacggcgc cagcaacaac      180

ccccacggcc ugagagaggc ccagagcacc agcaccagcg ccaccgccgc cagccacacc      240

agacaccccg agggcgugaa cgaccagaug gaggagagac ccaucugcac ccaggaccug      300

gaggccaccg acagcuuccc cagaggcccc guggacgaga aggugaucau ccuggugcac      360

uaccugcugu acaaguacca gaugaaggag cccaucacca aggccgacau gcugagaaac      420

gugacccaga ugagcaagag ccaguucccc gugauccuga gcagagccag cgagcaccug      480

gagcugaucu ucggccugga ccugaaggag guggagccca acaagcacau cuacgugcug      540

gugaacaagc uggaccuggg cugcgacgcc aagcugagcg acgagaccgg cgugcccaag      600

accggccugc ugaugaccgu gcugggcauc aucuucacca acggcaacug cguggccgag      660

gaggaggugu ggaagguguu caacaccaug ggccuguacg acggcaucga gcacuucaug      720

uucggcgagc ccagaaagcu gcugaccaag gaccugguga aggagaacua ccuggaguac      780

cagcaggugc ccaacagcga cccccccaga uaccaguucc uguggggccc cagagcccac      840

gccgagacca gcaagaugaa ggugcuggag uuccuggcca aggugaacga caccgccccc      900

agcgaguuca gcaacuggua caccgaggcc cugcaggacg aggaggagag agccagagcc      960

agaguggccg ccaaggccag agugagcgcc accgccggcg ccagaagcaa ggugaagagc     1020

agcaagagca gccagcugca guga                                            1044


<210>  2287
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B10__Homo_sapiens__AAI01309

<400>  2287
augcccagag gccaaaagag caaacugcgg gcccgcgaga agagacggca ggcucgcggg       60

ggacucgaag accugaucga ugcccuugac auucuggagg aagaggaaga guccccuccg      120

ucugcgagcg cuugccucaa agauguguuc caguccucuc uggacggcgc cagcaacaau      180

ccccacgggc uuagagaggc ccaguccacc ucuacaagcg cuacggccgc uucccauacc      240

cggcacccug aaggagugaa cgaucagaug gaggaacgcc ccaucuguac acaagaccug      300

gaggccaccg auagcuuucc uagaggcccc guugacgaga aggugauuau ccucgugcau      360

uaccugcugu auaaauacca gaugaaggaa ccuauuacaa aggcggauau gcuccggaau      420

gucacccaga ugucuaaauc ccaguucccg gugauccuga gccgcgccuc ugagcaccuu      480

gaacugaucu uugggcucga ccugaaggag guugaaccca acaaacauau uuaugugcuu      540

gucaauaagc uggaucucgg augcgacgcu aaacuguccg augagacagg cgugccuaag      600

accggccugc ucaugacggu ucuggggauc auuuucacca acggaaauug uguggccgag      660

gaagaggucu ggaagguguu uaacacaaug ggccuuuacg acgggaucga acacuucaug      720

uuuggagagc ccagaaaacu gcucaccaag gaccugguga aagaaaauua ucuugaguac      780

caacaggucc cuaacagcga ucccccgcgg uaucaguucc uguggggccc ucgcgcucac      840

gccgagacau cuaagaugaa aguucucgaa uuucuggcga aggugaauga caccgccccc      900

uccgaguuca gcaacuggua cacggaagcu cugcaggaug aggaagagag agcccgggcu      960

cgcguggccg ccaaagcuag agucuccgcg acagccgggg cucggucuaa ggucaagagc     1020

uccaaaagcu cucaacucca guga                                            1044


<210>  2288
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B16__Homo_sapiens__A2A368

<400>  2288

Met Ser Gln Asp Gln Glu Ser Pro Arg Cys Thr His Asp Gln His Leu 
1               5                   10                  15      


Gln Thr Phe Ser Glu Thr Gln Ser Leu Glu Val Ala Gln Val Ser Lys 
            20                  25                  30          


Ala Leu Glu Lys Thr Leu Leu Ser Ser Ser His Pro Leu Val Pro Gly 
        35                  40                  45              


Lys Leu Lys Glu Ala Pro Ala Ala Lys Ala Glu Ser Pro Leu Glu Val 
    50                  55                  60                  


Pro Gln Ser Phe Cys Ser Ser Ser Ile Ala Val Thr Thr Thr Ser Ser 
65                  70                  75                  80  


Ser Glu Ser Asp Glu Ala Ser Ser Asn Gln Glu Glu Glu Asp Ser Pro 
                85                  90                  95      


Ser Ser Ser Glu Asp Thr Ser Asp Pro Arg Asn Val Pro Ala Asp Ala 
            100                 105                 110         


Leu Asp Gln Lys Val Ala Phe Leu Val Asn Phe Met Leu His Lys Cys 
        115                 120                 125             


Gln Met Lys Lys Pro Ile Thr Lys Ala Asp Met Leu Lys Ile Ile Ile 
    130                 135                 140                 


Lys Asp Asp Glu Ser His Phe Ser Glu Ile Leu Leu Arg Ala Ser Glu 
145                 150                 155                 160 


His Leu Glu Met Ile Phe Gly Leu Asp Val Val Glu Val Asp Pro Thr 
                165                 170                 175     


Thr His Cys Tyr Gly Leu Phe Ile Lys Leu Gly Leu Thr Tyr Asp Gly 
            180                 185                 190         


Met Leu Ser Gly Glu Lys Gly Val Pro Lys Thr Gly Leu Leu Ile Ile 
        195                 200                 205             


Val Leu Gly Val Ile Phe Met Lys Gly Asn Arg Ala Thr Glu Glu Glu 
    210                 215                 220                 


Val Trp Glu Val Leu Asn Leu Thr Gly Val Tyr Ser Gly Lys Lys His 
225                 230                 235                 240 


Phe Ile Phe Gly Glu Pro Arg Met Leu Ile Thr Lys Asp Phe Val Lys 
                245                 250                 255     


Glu Lys Tyr Leu Glu Tyr Gln Gln Val Ala Asn Ser Asp Pro Ala Arg 
            260                 265                 270         


Tyr Glu Phe Leu Trp Gly Pro Arg Ala Lys Ala Glu Thr Ser Lys Met 
        275                 280                 285             


Lys Val Leu Glu Phe Val Ala Lys Val His Gly Ser Tyr Pro His Ser 
    290                 295                 300                 


Phe Pro Ser Gln Tyr Ala Glu Ala Leu Lys Glu Glu Glu Glu Arg Ala 
305                 310                 315                 320 


Arg Ala Arg Ile 
                


<210>  2289
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2289
augucucagg aucaggagag uccacgaugc acacaugauc agcaccuuca gaccuucagu       60

gagacccaga gccuggaggu ugcacagguc uccaaggcuc uggagaagac ccuccucucc      120

uccucccauc cucuagugcc uggcaaacug aaggaagcuc cugcugcuaa ggcagagagu      180

ccucuugagg uuccucagag uuucugcucc ucuuccauug ccgucacaac caccucauca      240

agugaaucug augaggcuuc cagcaaucaa gaagaggaag auaguccaag cuccucagag      300

gauacaucag accccaggaa ugugcccgca gaugcucucg accagaaagu ggcuuuuuug      360

gugaauuuca ugcugcacaa gugucagaug aaaaagccaa uaacaaaggc agauauguug      420

aagauuauca ucaaagauga ugagagccac uucucugaga uccuccugag agcuucugag      480

caccuagaga ugauauuugg ccuugaugug guggaggugg accccaccac ccauugcuau      540

ggccucuuca ucaaacuggg ccucaccuau gaugggaugc ugagugguga aaagggugug      600

cccaagacug gccuccugau aauuguccug ggugugaucu ucaugaaggg caaccgugcc      660

acugaagagg aagucuggga agugcugaau uugacgggag uauauucugg gaagaagcac      720

uucaucuuug gagagcccag aaugcucauc accaaagauu uugugaagga gaaguaccug      780

gaguaccagc agguggccaa cagugauccu gcacgauaug aauuccugug gggcccaaga      840

gccaaagcug aaaccagcaa gaugaaaguc cuggaguuug uggccaaagu ucaugggucu      900

uacccacauu cuuucccauc ucaguaugcg gaagcucuga aagaggaaga agagagagcu      960

agagccagaa uuuga                                                       975


<210>  2290
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2290
augagccagg accaggagag cccccgcugc acccacgacc agcaccucca gaccuucucc       60

gagacgcagu cccuggaggu ggcccagguc agcaaggccc uggagaagac ccugcucucc      120

agcucccacc cgcuggugcc cggcaagcug aaggaggcgc ccgccgccaa ggccgagagc      180

ccccucgagg ugccgcaguc cuucugcagc uccagcaucg ccgucaccac cacguccagc      240

uccgagagcg acgaggcguc cagcaaccag gaggaggagg acucccccag cagcuccgag      300

gacaccagcg acccccggaa cgugcccgcc gacgcccugg accagaaggu ggccuuccug      360

gucaacuuca ugcuccacaa gugccagaug aagaagccga ucaccaaggc ggacaugcug      420

aagaucauca ucaaggacga cgagucccac uucagcgaga uccugcuccg cgccuccgag      480

caccuggaga ugaucuucgg gcuggacgug guggaggucg accccaccac gcacugcuac      540

ggccucuuca ucaagcuggg gcugaccuac gacggcaugc ucagcgggga gaagggcgug      600

cccaagaccg gccugcugau caucgugcuc ggggucaucu ucaugaaggg caaccgggcc      660

accgaggagg agguguggga ggugcugaac cugacggggg ucuacuccgg caagaagcac      720

uucaucuucg gggagccccg caugcucauc accaaggacu ucgugaagga gaaguaccug      780

gaguaccagc aggucgccaa cagcgacccg gcccgguacg aguuccugug gggcccccgc      840

gcgaaggccg agaccuccaa gaugaaggug cucgaguucg uggccaaggu gcacggcagc      900

uacccccacu ccuuccccag ccaguacgcc gaggcccuga aggaggagga ggagcgggcg      960

cgcgcccgga ucuga                                                       975


<210>  2291
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2291
augucccagg accaggaguc cccccgcugc acccacgacc agcaccucca gaccuucucc       60

gagacccagu cccucgaggu cgcccagguc uccaaggccc ucgagaagac ccuccucucc      120

uccucccacc cccucguccc cggcaagcuc aaggaggccc ccgccgccaa ggccgagucc      180

ccccucgagg ucccccaguc cuucugcucc uccuccaucg ccgucaccac caccuccucc      240

uccgaguccg acgaggccuc cuccaaccag gaggaggagg acucccccuc cuccuccgag      300

gacaccuccg acccccgcaa cguccccgcc gacgcccucg accagaaggu cgccuuccuc      360

gucaacuuca ugcuccacaa gugccagaug aagaagccca ucaccaaggc cgacaugcuc      420

aagaucauca ucaaggacga cgagucccac uucuccgaga uccuccuccg cgccuccgag      480

caccucgaga ugaucuucgg ccucgacguc gucgaggucg accccaccac ccacugcuac      540

ggccucuuca ucaagcucgg ccucaccuac gacggcaugc ucuccggcga gaagggcguc      600

cccaagaccg gccuccucau caucguccuc ggcgucaucu ucaugaaggg caaccgcgcc      660

accgaggagg aggucuggga gguccucaac cucaccggcg ucuacuccgg caagaagcac      720

uucaucuucg gcgagccccg caugcucauc accaaggacu ucgucaagga gaaguaccuc      780

gaguaccagc aggucgccaa cuccgacccc gcccgcuacg aguuccucug gggcccccgc      840

gccaaggccg agaccuccaa gaugaagguc cucgaguucg ucgccaaggu ccacggcucc      900

uacccccacu ccuuccccuc ccaguacgcc gaggcccuca aggaggagga ggagcgcgcc      960

cgcgcccgca ucuga                                                       975


<210>  2292
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2292
augagccagg accaagaguc ccccagaugc acccacgauc agcaucugca gacauucucu       60

gaaacucagu cacucgaggu ggcccaaguc aguaaggcuc uugagaaaac gcuguugagc      120

uccucucacc cuuuaguucc aggcaagcug aaagaagcac cggccgcgaa ggcugaaucg      180

ccccuagagg ugccucaguc auuuuguagc aguuccaucg ccguaaccac aacuucuagc      240

uccgagucag acgaagcaag uagcaaccag gaggaagagg auucuccauc cucaagcgag      300

gacaccagug aucccaggaa ugugccugcc gacgcucucg aucagaaagu cgcauuccug      360

gugaacuuua ugcuucauaa gugccaaaug aagaaaccaa uuacaaaggc cgacaugcug      420

aaaauaauca uuaaggauga cgaaucucac uucuccgaga ucuugcuccg ggcuagcgaa      480

caucuggaga ugauuuuugg gcuggauguu guggaagucg accccaccac ucacuguuac      540

ggacucuuca ucaaauuagg ucugacauau gauggcaugc uuucggggga gaagggagug      600

ccuaagaccg gcuugcugau aaucguacua gguguuauuu uuaugaaagg gaaucgcgcc      660

acggaggaag agguguggga aguccucaac cugacuggag uguacucugg caagaaacac      720

uucaucuuug gcgagccacg aaugcuuauu accaaggacu ucgugaaaga aaaguaucug      780

gaguaccagc aggucgcaaa uuccgacccg gcgcguuaug aguuuuugug ggggcccaga      840

gccaaagcug aaacaucaaa gaugaagguu cucgaguucg uggccaaagu acauggaagu      900

uacccucaca gcuuuccauc ccaguaugca gaagcucuga aggaggaaga ggagagggcc      960

cgggcgcgca ucuga                                                       975


<210>  2293
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2293
augagccagg accaggagag ccccagaugc acccacgacc agcaccugca gaccuucagc       60

gagacccaga gccuggaggu ggcccaggug agcaaggccc uggagaagac ccugcugagc      120

agcagccacc cccuggugcc cggcaagcug aaggaggccc ccgccgccaa ggccgagagc      180

ccccuggagg ugccccagag cuucugcagc agcagcaucg ccgugaccac caccagcagc      240

agcgagagcg acgaggccag cagcaaccag gaggaggagg acagccccag cagcagcgag      300

gacaccagcg accccagaaa cgugcccgcc gacgcccugg accagaaggu ggccuuccug      360

gugaacuuca ugcugcacaa gugccagaug aagaagccca ucaccaaggc cgacaugcug      420

aagaucauca ucaaggacga cgagagccac uucagcgaga uccugcugag agccagcgag      480

caccuggaga ugaucuucgg ccuggacgug guggaggugg accccaccac ccacugcuac      540

ggccuguuca ucaagcuggg ccugaccuac gacggcaugc ugagcggcga gaagggcgug      600

cccaagaccg gccugcugau caucgugcug ggcgugaucu ucaugaaggg caacagagcc      660

accgaggagg agguguggga ggugcugaac cugaccggcg uguacagcgg caagaagcac      720

uucaucuucg gcgagcccag aaugcugauc accaaggacu ucgugaagga gaaguaccug      780

gaguaccagc agguggccaa cagcgacccc gccagauacg aguuccugug gggccccaga      840

gccaaggccg agaccagcaa gaugaaggug cuggaguucg uggccaaggu gcacggcagc      900

uacccccaca gcuuccccag ccaguacgcc gaggcccuga aggaggagga ggagagagcc      960

agagccagaa ucuga                                                       975


<210>  2294
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B16__Homo_sapiens__CCDS43927.1

<400>  2294
augagccagg accaggaguc ccccagaugc acccacgauc agcaucugca gacauucucu       60

gaaacgcaga gccucgaggu ggcccaaguc uccaaggcuc uggagaaaac ccuucugucu      120

agcucccacc cucucguucc gggcaagcug aaagaagccc ccgcggcuaa ggccgaaucu      180

ccucuugagg ugccccagag cuuuuguucc agcucuaucg ccgugacaac cacauccagc      240

ucugaguccg acgaagcuag cucuaaccag gaggaagagg auuccccuag cuccucugag      300

gacaccagcg auccccggaa ugucccugcc gacgcucugg aucagaaagu ggccuuccuc      360

guuaacuuua ugcugcauaa gugccaaaug aagaaaccga uuacaaaggc ggacaugcug      420

aaaaucauua ucaaggauga cgaaucccac uucagcgaga uucuccugcg cgccucugaa      480

caucuugaga ugaucuuugg gcuggaugug gucgaagugg accccaccac gcacuguuac      540

ggacucuuca ucaaacuggg ccuuaccuau gaugggaugc uguccggaga gaagggcguu      600

ccuaagacag ggcuccugau uaucgugcug ggagucauuu uuaugaaagg caauagagcu      660

accgaggaag agguguggga agugcucaac cugacaggcg ucuacagcgg gaagaaacac      720

uucaucuuug gagagccccg gaugcuuauu accaaggacu ucguuaaaga aaaguaucug      780

gaguaccaac agguggccaa uucugacccu gcucgcuaug aguuucucug gggccccaga      840

gccaaagcgg aaacgagcaa gaugaaggug cuggaguucg ucgccaaagu gcaugggucc      900

uacccgcacu cuuuuccuag ccaguaugcu gaagcccuua aggaggaaga ggagcgggcu      960

cgcgccagaa ucuga                                                       975


<210>  2295
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B17__Homo_sapiens__A8MXT2

<400>  2295

Met Pro Arg Gly Gln Ala Ser Lys Arg Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Gln Ala Arg Gly Glu Asp Gln Cys Leu Gly Gly Ala Gln Ala Thr Ala 
            20                  25                  30          


Ala Glu Lys Glu Lys Leu Pro Ser Ser Ser Ser Pro Ala Cys Gln Ser 
        35                  40                  45              


Pro Pro Gln Ser Phe Pro Asn Ala Gly Ile Pro Gln Glu Ser Gln Arg 
    50                  55                  60                  


Ala Ser Tyr Pro Ser Ser Pro Ala Ser Ala Val Ser Leu Thr Ser Ser 
65                  70                  75                  80  


Asp Glu Gly Ala Lys Gly Gln Lys Gly Glu Ser Pro Asn Ser Phe His 
                85                  90                  95      


Gly Pro Ser Ser Ser Glu Ser Thr Gly Arg Asp Leu Leu Asn Thr Lys 
            100                 105                 110         


Thr Gly Glu Leu Val Gln Phe Leu Leu Asn Lys Tyr Ile Arg Lys Glu 
        115                 120                 125             


Pro Ile Thr Arg Glu Ala Met Leu Lys Val Ile Asn Arg Lys Tyr Lys 
    130                 135                 140                 


Gln His Phe Pro Glu Ile Leu Arg Arg Ser Thr Glu Asn Val Glu Val 
145                 150                 155                 160 


Val Phe Gly Leu Tyr Leu Lys Glu Met Asp Pro Ser Arg Gln Ser Tyr 
                165                 170                 175     


Val Leu Val Gly Lys Leu Asp Phe Pro Asn Gln Gly Ser Leu Ser Asp 
            180                 185                 190         


Gly Gly Gly Phe Pro Leu Ser Gly Leu Leu Met Val Leu Leu Ser Thr 
        195                 200                 205             


Ile Phe Met His Gly Asn Arg Ala Thr Glu Glu Glu Met Trp Glu Cys 
    210                 215                 220                 


Leu Asn Ala Leu Gly Met Tyr Lys Gly Arg Lys His Phe Ile Tyr Gly 
225                 230                 235                 240 


Glu Pro Gln Glu Leu Val Thr Lys Asp Leu Val Arg Glu Gly Tyr Leu 
                245                 250                 255     


Glu Tyr Gln Gln Val Pro Ser Ser Asp Pro Pro Arg Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Arg Ala Glu Thr Ser Lys Met Lys Val Leu Glu 
        275                 280                 285             


Phe Val Ala Lys Leu Asn Asp Thr Val Ala Ser Thr Tyr Lys Ser Arg 
    290                 295                 300                 


Tyr Glu Glu Ala Leu Arg Glu Glu Glu Glu Gln Ala Arg Ala Arg Ala 
305                 310                 315                 320 


Val Ala Arg Asp Ser Ala Arg Ala Arg Ala Ser Arg Ser Phe Gln Pro 
                325                 330                 335     






<210>  2296
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2296
augccucgcg gucaggcgag uaagcgccgu gcccgugaga aacgccgcca ggcucgaggu       60

gaagaccaau gucucggggg ugcucaagcc accgcagcag agaaggaaaa gcugccaucc      120

uccuccucuc cugcaugcca gaguccuccc cagagcuucc ccaaugcagg cauuccucag      180

gagucccaga gagccagcua ccccagcucu ccugcuucag cuguuucacu cacaaguucu      240

gaugaaggug ccaagggcca aaagggggaa agucccaacu ccuuccaugg cccguccucc      300

ucugagagca caggaagaga ucuucugaac acgaagacgg gcgaauuggu gcaguuccuc      360

cucaacaagu auauaaggaa agagcccauu acgagggaag ccaugcugaa gguuaucaac      420

agaaaguaca agcagcacuu cccugagauc cuccggagaa gcacugagaa cguagaggug      480

gucuuuggcc ucuaccugaa ggaaauggac cccagccguc aguccuaugu gcuuguuggc      540

aagcuggacu uucccaauca aggaagcuug agcgauggcg ggggcuuucc ccugagcggg      600

cuccugaugg uucuccugag caccaucuuc augcauggca accgugccac ugaggaagag      660

augugggaau gccugaaugc auuggggaug uauaagggua ggaagcacuu caucuauggg      720

gagccccagg agcuugucac caaagauuug gugcgagagg gguaccugga guaccagcag      780

gugcccagca gcgauccucc acgcuacgag uuccuguggg gucccagggc ccgugcugaa      840

accagcaaaa ugaaaguccu ggaguuugug gccaagcuca augauaccgu ugccaguacc      900

uacaaguccc gguaugagga ggcucugaga gaggaggaag agcaagccag agccagagcg      960

guagccaggg auagcgccag ggccagggcu agcagguccu uucagcccua g              1011


<210>  2297
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2297
augccccgcg gccaggccag caagcggcgc gcccgggaga agcgccggca ggcgcgcggg       60

gaggaccagu gccugggcgg ggcccaggcc accgccgccg agaaggagaa gcucccgucc      120

agcuccagcc ccgcgugcca guccccgccc cagagcuucc ccaacgccgg caucccccag      180

gagucccagc gggccagcua ccccuccagc cccgccuccg cggugagccu gaccuccagc      240

gacgaggggg ccaagggcca gaagggcgag uccccgaaca gcuuccacgg gcccuccagc      300

uccgagagca cgggccgcga ccugcucaac accaagaccg gggagcuggu ccaguuccug      360

cucaacaagu acauccggaa ggagcccauc acccgcgagg ccaugcugaa ggugaucaac      420

cggaaguaca agcagcacuu ccccgagauc cugcgccgga gcacggagaa cguggagguc      480

guguucggcc ucuaccugaa ggagauggac ccgucccgcc agagcuacgu gcuggucggg      540

aagcucgacu uccccaacca gggcucccug agcgacggcg ggggcuuccc ccuguccggg      600

cuccugaugg ugcugcucag caccaucuuc augcacggca accgggccac cgaggaggag      660

augugggagu gccugaacgc ccugggcaug uacaaggggc gcaagcacuu caucuacggc      720

gagccccagg agcucgugac caaggaccug guccgggagg gguaccugga guaccagcag      780

gucccgucca gcgacccgcc ccgcuacgag uuccucuggg gcccccgggc gcgcgccgag      840

acguccaaga ugaaggugcu ggaguucgug gccaagcuga acgacaccgu ggccagcacc      900

uacaaguccc gguacgagga ggcccuccgc gaggaggagg agcaggcgcg cgcccgggcc      960

guggcccgcg acagcgcccg ggcgcgcgcc ucccggagcu uccagcccug a              1011


<210>  2298
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2298
augccccgcg gccaggccuc caagcgccgc gcccgcgaga agcgccgcca ggcccgcggc       60

gaggaccagu gccucggcgg cgcccaggcc accgccgccg agaaggagaa gcuccccucc      120

uccuccuccc ccgccugcca gucccccccc caguccuucc ccaacgccgg caucccccag      180

gagucccagc gcgccuccua ccccuccucc cccgccuccg ccgucucccu caccuccucc      240

gacgagggcg ccaagggcca gaagggcgag ucccccaacu ccuuccacgg ccccuccucc      300

uccgagucca ccggccgcga ccuccucaac accaagaccg gcgagcucgu ccaguuccuc      360

cucaacaagu acauccgcaa ggagcccauc acccgcgagg ccaugcucaa ggucaucaac      420

cgcaaguaca agcagcacuu ccccgagauc cuccgccgcu ccaccgagaa cgucgagguc      480

gucuucggcc ucuaccucaa ggagauggac cccucccgcc aguccuacgu ccucgucggc      540

aagcucgacu uccccaacca gggcucccuc uccgacggcg gcggcuuccc ccucuccggc      600

cuccucaugg uccuccucuc caccaucuuc augcacggca accgcgccac cgaggaggag      660

augugggagu gccucaacgc ccucggcaug uacaagggcc gcaagcacuu caucuacggc      720

gagccccagg agcucgucac caaggaccuc guccgcgagg gcuaccucga guaccagcag      780

guccccuccu ccgacccccc ccgcuacgag uuccucuggg gcccccgcgc ccgcgccgag      840

accuccaaga ugaagguccu cgaguucguc gccaagcuca acgacaccgu cgccuccacc      900

uacaaguccc gcuacgagga ggcccuccgc gaggaggagg agcaggcccg cgcccgcgcc      960

gucgcccgcg acuccgcccg cgcccgcgcc ucccgcuccu uccagcccug a              1011


<210>  2299
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2299
augcccagag gccaggccag caagaggcgg gcucgcgaga aacgacguca agcaagaggg       60

gaagaccagu gccugggagg ugcccaggcg accgcugccg agaaggaaaa acucccuucc      120

ucuucaaguc cagcauguca gagcccgccc caauccuucc cuaacgccgg caucccacag      180

gagucucaga gggcuucgua ccccucaagc ccugcaagug ccgugucccu uacaucuagc      240

gaugaagggg cuaagggaca gaaaggcgag uccccaaauu cauuucacgg ucccaguagc      300

ucugagucca cugggcggga ccuguugaac acgaagaccg gagaauuagu ccaauuccug      360

cuaaauaagu auauucgcaa agagccuaua acaagagaag ccaugcucaa gguuaucaac      420

aggaaauaca agcagcauuu uccagagauu cugcggcgcu caacugagaa uguggaagua      480

guguucggcc uuuaucugaa agagauggau ccgagccgac agaguuacgu cuuggugggc      540

aagcucgacu uucccaacca ggggucucug uccgauggag guggcuuccc ucugagcggg      600

cucuuaaugg uucugcuuuc gaccaucuuu augcacggaa auagagcgac agaagaggaa      660

augugggagu gcuugaacgc acugggcaug uauaagggua ggaaacauuu cauuuacggg      720

gagccacaag agcuagugac caaggaccuc guccgggaag gauaucugga auaccaacag      780

gugcccucuu ccgauccucc acguuacgag uuucuuuggg gcccccgcgc cagagcugaa      840

acuucaaaaa ugaagguacu ggaguucguu gccaaauuga augacacagu ggcaaguacc      900

uauaagagca gguacgagga agcucuccgg gaggaagagg aacaggcccg agcgcgcgcc      960

gucgcaagag auuccgcuag ggcccgggcu ucucgcagcu uucagccgug a              1011


<210>  2300
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2300
augcccagag gccaggccag caagagaaga gccagagaga agagaagaca ggccagaggc       60

gaggaccagu gccugggcgg cgcccaggcc accgccgccg agaaggagaa gcugcccagc      120

agcagcagcc ccgccugcca gagccccccc cagagcuucc ccaacgccgg caucccccag      180

gagagccaga gagccagcua ccccagcagc cccgccagcg ccgugagccu gaccagcagc      240

gacgagggcg ccaagggcca gaagggcgag agccccaaca gcuuccacgg ccccagcagc      300

agcgagagca ccggcagaga ccugcugaac accaagaccg gcgagcuggu gcaguuccug      360

cugaacaagu acaucagaaa ggagcccauc accagagagg ccaugcugaa ggugaucaac      420

agaaaguaca agcagcacuu ccccgagauc cugagaagaa gcaccgagaa cguggaggug      480

guguucggcc uguaccugaa ggagauggac cccagcagac agagcuacgu gcuggugggc      540

aagcuggacu uccccaacca gggcagccug agcgacggcg gcggcuuccc ccugagcggc      600

cugcugaugg ugcugcugag caccaucuuc augcacggca acagagccac cgaggaggag      660

augugggagu gccugaacgc ccugggcaug uacaagggca gaaagcacuu caucuacggc      720

gagccccagg agcuggugac caaggaccug gugagagagg gcuaccugga guaccagcag      780

gugcccagca gcgacccccc cagauacgag uuccuguggg gccccagagc cagagccgag      840

accagcaaga ugaaggugcu ggaguucgug gccaagcuga acgacaccgu ggccagcacc      900

uacaagagca gauacgagga ggcccugaga gaggaggagg agcaggccag agccagagcc      960

guggccagag acagcgccag agccagagcc agcagaagcu uccagcccug a              1011


<210>  2301
<211>  1011
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B17__Homo_sapiens__CCDS59524.1

<400>  2301
augcccagag gccaggccag caagcggcgc gcuagagaga aacggcgcca agccagaggg       60

gaagaccagu gccugggagg cgcgcaggcu accgccgccg agaaggaaaa acucccuucc      120

ucuagcuccc cggcuuguca gucucccccu cagagcuucc ccaacgccgg gaucccucaa      180

gagucccagc gggcuucuua ccccagcucc ccugccagcg cggugucucu gacauccagc      240

gaugaaggag ccaagggcca gaaaggggag ucuccgaaua gcuuucacgg acccuccucu      300

uccgagagca cgggccgcga ccuucugaac accaagacag gcgaacucgu ccaauuccug      360

cuuaauaagu auauuagaaa agagccuauc acccgggaag cuaugcugaa gguuauuaac      420

cgcaaauaca agcagcauuu ucccgagauc cucagacggu ccacagagaa uguggaagug      480

gucuucgggc uguaucugaa agagauggau ccuucucgcc agagcuacgu gcucguugga      540

aagcuggacu uucccaacca gggcucccuu agcgaugggg gaggcuuccc gcugucuggg      600

cuccugaugg ugcuucuguc caccauuuuu augcacggaa auagagccac agaagaggaa      660

augugggagu gccucaacgc ucugggcaug uauaagggcc ggaaacauuu caucuacggg      720

gagccucaag aacuggucac caaggaccuc gugcgcgagg gauaucugga auaccagcag      780

guucccagcu cugauccucc cagauacgag uuucuuuggg gcccccgggc cagagcggaa      840

acgagcaaaa ugaaggugcu ggaguucguc gccaaacuca augacaccgu ggcuuccaca      900

uauaagucuc gcuacgagga agcccugcgg gaggaagagg aacaagcuag agcccgcgcc      960

guggcucggg auagcgcgag agcccgcgcu ucccggagcu uucagccuug a              1011


<210>  2302
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-_B1__Homo_sapiens__Q96TG1

<400>  2302

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Lys Ala Arg Glu Glu Thr Gln Gly Leu Lys Val Arg His Ala Thr Ala 
            20                  25                  30          


Ala Glu Lys Glu Glu Cys Pro Ser Ser Ser Pro Val Leu Gly Asp Thr 
        35                  40                  45              


Pro Thr Ser Ser Pro Ala Ala Gly Ile Pro Gln Lys Pro Gln Gly Ala 
    50                  55                  60                  


Pro Pro Thr Thr Thr Ala Ala Ala Ala Val Ser Cys Thr Glu Ser Asp 
65                  70                  75                  80  


Glu Gly Ala Lys Cys Gln Gly Glu Glu Asn Ala Ser Phe Ser Gln Ala 
                85                  90                  95      


Thr Thr Ser Thr Glu Ser Ser Val Lys Asp Pro Val Ala Trp Glu Ala 
            100                 105                 110         


Gly Met Leu Met His Phe Ile Leu Arg Lys Tyr Lys Met Arg Glu Pro 
        115                 120                 125             


Ile Met Lys Ala Asp Met Leu Lys Val Val Asp Glu Lys Tyr Lys Asp 
    130                 135                 140                 


His Phe Thr Glu Ile Leu Asn Gly Ala Ser Arg Arg Leu Glu Leu Val 
145                 150                 155                 160 


Phe Gly Leu Asp Leu Lys Glu Asp Asn Pro Ser Ser His Thr Tyr Thr 
                165                 170                 175     


Leu Val Ser Lys Leu Asn Leu Thr Asn Asp Gly Asn Leu Ser Asn Asp 
            180                 185                 190         


Trp Asp Phe Pro Arg Asn Gly Leu Leu Met Pro Leu Leu Gly Val Ile 
        195                 200                 205             


Phe Leu Lys Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp Lys Phe Met 
    210                 215                 220                 


Asn Val Leu Gly Ala Tyr Asp Gly Glu Glu His Leu Ile Tyr Gly Glu 
225                 230                 235                 240 


Pro Arg Lys Phe Ile Thr Gln Asp Leu Val Gln Glu Lys Tyr Leu Lys 
                245                 250                 255     


Tyr Glu Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln Phe Leu Trp 
            260                 265                 270         


Gly Pro Arg Ala Tyr Ala Glu Thr Thr Lys Met Lys Val Leu Glu Phe 
        275                 280                 285             


Leu Ala Lys Met Asn Gly Ala Thr Pro Arg Asp Phe Pro Ser His Tyr 
    290                 295                 300                 


Glu Glu Ala Leu Arg Asp Glu Glu Glu Arg Ala Gln Val Arg Ser Ser 
305                 310                 315                 320 


Val Arg Ala Arg Arg Arg Thr Thr Ala Thr Thr Phe Arg Ala Arg Ser 
                325                 330                 335     


Arg Ala Pro Phe Ser Arg Ser Ser His Pro Met 
            340                 345         


<210>  2303
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-_B1__Homo_sapiens__AAC23616

<400>  2303
augccucggg gucagaagag uaagcuccgu gcucgugaga aacgccgcaa ggcgcgagag       60

gagacccagg gucucaaggu ucgucacgcc acugcagcag agaaagagga gugccccucc      120

uccucuccug uuuuagggga uacucccaca agcuccccug cugcuggcau uccccagaag      180

ccucagggag cuccacccac caccacugcu gcugcagcug ugucauguac cgaaucugac      240

gaaggugcca aaugccaagg ugaggaaaau gcaaguuucu cccaggccac aacauccacu      300

gagagcucag ucaaagaucc uguagccugg gaggcaggaa ugcugaugca cuucauucua      360

cguaaguaua aaaugagaga gcccauuaug aaggcagaua ugcugaaggu uguugaugaa      420

aaguacaagg aucacuucac ugagauccuc aauggagccu cucgccgcuu ggagcucguc      480

uuuggccuug auuugaagga agacaacccu aguagccaca ccuacacccu cgucaguaag      540

cuaaaccuca ccaaugaugg aaaccugagc aaugauuggg acuuucccag gaaugggcuu      600

cugaugccuc uccugggugu gaucuucuua aagggcaacu cugccaccga ggaagagauc      660

uggaaauuca ugaauguguu gggagccuau gauggagagg agcacuuaau cuauggggaa      720

ccccguaagu ucaucaccca agaucuggug caggaaaaau aucugaagua cgagcaggug      780

cccaacagug aucccccacg cuaucaauuc cuaugggguc cgagagccua ugcugaaacc      840

accaagauga aaguccucga guuuuuggcc aagaugaaug gugccacucc ccgugacuuc      900

ccaucccauu augaagaggc uuugagagau gaggaagaga gagcccaagu ccgauccagu      960

guuagagcca ggcgucgcac uacugccacg acuuuuagag cgcguucuag agccccauuc     1020

agcagguccu cccaccccau guga                                            1044


<210>  2304
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-_B1__Homo_sapiens__AAC23616

<400>  2304
augccccgcg gccagaaguc caagcugcgg gcccgcgaga agcggcgcaa ggcccgggag       60

gagacccagg ggcucaaggu gcgccacgcg accgccgccg agaaggagga gugcccgagc      120

agcucccccg uccugggcga cacgcccacc agcucccccg ccgccgggau cccgcagaag      180

ccccagggcg cgccgcccac caccacggcc gccgccgcgg ugagcugcac cgaguccgac      240

gagggggcca agugccaggg cgaggagaac gccagcuucu cccaggccac caccagcacg      300

gaguccagcg ugaaggaccc cgucgccugg gaggcgggca ugcugaugca cuucauccuc      360

cggaaguaca agaugcgcga gcccaucaug aaggccgaca ugcugaaggu gguggacgag      420

aaguacaagg accacuucac cgagauccug aacggggccu cccggcgccu cgagcugguc      480

uucggccugg accucaagga ggacaacccc agcucccaca ccuacacccu ggugagcaag      540

cugaaccuca cgaacgacgg gaaccugucc aacgacuggg acuucccccg gaacggccug      600

cucaugccgc ugcugggggu gaucuuccuc aagggcaaca gcgccaccga ggaggagauc      660

uggaaguuca ugaacguccu gggcgccuac gacggggagg agcaccugau cuacggcgag      720

ccccgcaagu ucaucaccca ggaccucgug caggagaagu accugaagua cgagcagguc      780

cccaacuccg acccgccccg guaccaguuc cugugggggc cccgcgcgua cgccgagacc      840

acgaagauga aggugcucga guuccuggcc aagaugaacg gcgccacgcc ccgggacuuc      900

cccagccacu acgaggaggc ccugcgcgac gaggaggagc gggcccaggu gcgcagcucc      960

gugcgggcgc gccggcgcac caccgccacc accuuccgcg cccggagccg cgccccguuc     1020

ucccggagcu cccaccccau guga                                            1044


<210>  2305
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-_B1__Homo_sapiens__AAC23616

<400>  2305
augccccgcg gccagaaguc caagcuccgc gcccgcgaga agcgccgcaa ggcccgcgag       60

gagacccagg gccucaaggu ccgccacgcc accgccgccg agaaggagga gugccccucc      120

uccucccccg uccucggcga cacccccacc uccucccccg ccgccggcau cccccagaag      180

ccccagggcg ccccccccac caccaccgcc gccgccgccg ucuccugcac cgaguccgac      240

gagggcgcca agugccaggg cgaggagaac gccuccuucu cccaggccac caccuccacc      300

gaguccuccg ucaaggaccc cgucgccugg gaggccggca ugcucaugca cuucauccuc      360

cgcaaguaca agaugcgcga gcccaucaug aaggccgaca ugcucaaggu cgucgacgag      420

aaguacaagg accacuucac cgagauccuc aacggcgccu cccgccgccu cgagcucguc      480

uucggccucg accucaagga ggacaacccc uccucccaca ccuacacccu cgucuccaag      540

cucaaccuca ccaacgacgg caaccucucc aacgacuggg acuucccccg caacggccuc      600

cucaugcccc uccucggcgu caucuuccuc aagggcaacu ccgccaccga ggaggagauc      660

uggaaguuca ugaacguccu cggcgccuac gacggcgagg agcaccucau cuacggcgag      720

ccccgcaagu ucaucaccca ggaccucguc caggagaagu accucaagua cgagcagguc      780

cccaacuccg accccccccg cuaccaguuc cucuggggcc cccgcgccua cgccgagacc      840

accaagauga agguccucga guuccucgcc aagaugaacg gcgccacccc ccgcgacuuc      900

cccucccacu acgaggaggc ccuccgcgac gaggaggagc gcgcccaggu ccgcuccucc      960

guccgcgccc gccgccgcac caccgccacc accuuccgcg cccgcucccg cgcccccuuc     1020

ucccgcuccu cccaccccau guga                                            1044


<210>  2306
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-_B1__Homo_sapiens__AAC23616

<400>  2306
augcccagag gccaaaagag caaacugagg gcccgggaga agcgccgaaa agcucgugaa       60

gagacccagg ggcucaaggu gagacacgca acagccgcgg aaaaagagga augcccuucc      120

ucuucaccag uccuuggaga cacuccgacg aguagccccg cugccgguau cccucagaag      180

ccacagggcg cacccccuac cacaacugcc gcugcagccg uuuccuguac cgagucugau      240

gagggggcua agugccaggg agaagagaac gccucguucu cacaagcgac aaccagcacu      300

gaaaguuccg ugaaagaccc aguagcaugg gaggccggca ugcugaugca uuuuauuuug      360

aggaaguaca aaaugcggga gcccauaaug aaggcugaua uguuaaaagu ggucgacgaa      420

aaguauaagg aucacuucac agagauccug aauggugccu cucgcagacu agaacucgug      480

uuugggcugg accuuaaaga ggauaacccu agcucccaua ccuacacgcu gguuucaaag      540

uugaaucuca cuaacgacgg aaaucugagu aacgauuggg acuucccaag gaauggccug      600

cucaugccgu uacugggcgu gauuuuucuu aaagggaaca gcgcaaccga agaggagauc      660

uggaaguuca ugaaugucuu gggagcuuau gauggugagg aacaccugau uuacggcgaa      720

ccccggaaau uuaucacaca ggaccuagug caggagaagu aucucaaaua cgaacaggua      780

ccuaacucug auccaccccg cuaucaauuc cugugggggc cucgagccua cgcggagacu      840

accaagauga agguucuuga guuucuggcc aaaaugaaug gagcaacacc aagagacuuc      900

cccucccauu acgaagaggc uuugagggac gaagaggaac gggcccaggu gcguucaagc      960

guccgcgcua gaaggcggac cacggccacu acauuucgag cacgcaguag agccccguuc     1020

ucuaggucca gccacccuau guga                                            1044


<210>  2307
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-_B1__Homo_sapiens__AAC23616

<400>  2307
augcccagag gccagaagag caagcugaga gccagagaga agagaagaaa ggccagagag       60

gagacccagg gccugaaggu gagacacgcc accgccgccg agaaggagga gugccccagc      120

agcagccccg ugcugggcga cacccccacc agcagccccg ccgccggcau cccccagaag      180

ccccagggcg ccccccccac caccaccgcc gccgccgccg ugagcugcac cgagagcgac      240

gagggcgcca agugccaggg cgaggagaac gccagcuuca gccaggccac caccagcacc      300

gagagcagcg ugaaggaccc cguggccugg gaggccggca ugcugaugca cuucauccug      360

agaaaguaca agaugagaga gcccaucaug aaggccgaca ugcugaaggu gguggacgag      420

aaguacaagg accacuucac cgagauccug aacggcgcca gcagaagacu ggagcuggug      480

uucggccugg accugaagga ggacaacccc agcagccaca ccuacacccu ggugagcaag      540

cugaaccuga ccaacgacgg caaccugagc aacgacuggg acuuccccag aaacggccug      600

cugaugcccc ugcugggcgu gaucuuccug aagggcaaca gcgccaccga ggaggagauc      660

uggaaguuca ugaacgugcu gggcgccuac gacggcgagg agcaccugau cuacggcgag      720

cccagaaagu ucaucaccca ggaccuggug caggagaagu accugaagua cgagcaggug      780

cccaacagcg acccccccag auaccaguuc cuguggggcc ccagagccua cgccgagacc      840

accaagauga aggugcugga guuccuggcc aagaugaacg gcgccacccc cagagacuuc      900

cccagccacu acgaggaggc ccugagagac gaggaggaga gagcccaggu gagaagcagc      960

gugagagcca gaagaagaac caccgccacc accuucagag ccagaagcag agcccccuuc     1020

agcagaagca gccaccccau guga                                            1044


<210>  2308
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-_B1__Homo_sapiens__AAC23616

<400>  2308
augcccagag gccaaaagag caaacugcgg gcccgcgaga agagacggaa agcucgcgaa       60

gagacccagg ggcucaaggu gagacacgcc acagcggcug aaaaagagga augcccuucc      120

ucuagcccgg uccugggaga cacgcccacc uccucuccug ccgccggcau cccccagaag      180

ccucaggggg cucccccuac aaccacagcc gcugccgcgg uuagcuguac cgaguccgau      240

gagggagcca agugccaggg cgaagagaac gcuucuuuca gccaagccac aaccuccacg      300

gaaagcucug ugaaagaccc gguggcuugg gaggccggga ugcuuaugca uuuuauucug      360

cggaaguaca aaaugcgcga gcccaucaug aaggcggaua ugcucaaagu cguggacgaa      420

aaguauaagg aucacuucac cgagauucug aauggagccu ccagacggcu ugaacugguu      480

uuuggccucg accugaaaga ggauaacccu agcucucaua cauacacccu gguguccaag      540

cucaaucuga caaacgacgg caaucuuagc aacgauuggg acuucccccg caaugggcug      600

cucaugccuc ugcuuggagu caucuuucug aaaggcaacu cugcuaccga agaggagauu      660

uggaaguuca ugaaugugcu cggggccuau gauggagagg aacaccugau cuacggcgaa      720

cccagaaaau uuaucacgca ggaccugguu caggagaagu aucucaaaua cgaacaggug      780

ccgaacuccg auccuccccg guaucaauuc cugugggggc cucgcgcuua cgccgagaca      840

accaagauga agguccuuga guuucuggcc aaaaugaaug gagcuacacc cagagacuuc      900

cccagccauu acgaagaggc gcuccgggac gaagaggaac gcgcccaggu gagauccucu      960

gugcgggcua gacgccggac caccgccaca acguuuagag cccgcagccg ggcuccuuuc     1020

uccagaagcu cucacccgau guga                                            1044


<210>  2309
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B2__Homo_sapiens__O15479

<400>  2309

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Lys Ala Arg Asp Glu Thr Arg Gly Leu Asn Val Pro Gln Val Thr Glu 
            20                  25                  30          


Ala Glu Glu Glu Glu Ala Pro Cys Cys Ser Ser Ser Val Ser Gly Gly 
        35                  40                  45              


Ala Ala Ser Ser Ser Pro Ala Ala Gly Ile Pro Gln Glu Pro Gln Arg 
    50                  55                  60                  


Ala Pro Thr Thr Ala Ala Ala Ala Ala Ala Gly Val Ser Ser Thr Lys 
65                  70                  75                  80  


Ser Lys Lys Gly Ala Lys Ser His Gln Gly Glu Lys Asn Ala Ser Ser 
                85                  90                  95      


Ser Gln Ala Ser Thr Ser Thr Lys Ser Pro Ser Glu Asp Pro Leu Thr 
            100                 105                 110         


Arg Lys Ser Gly Ser Leu Val Gln Phe Leu Leu Tyr Lys Tyr Lys Ile 
        115                 120                 125             


Lys Lys Ser Val Thr Lys Gly Glu Met Leu Lys Ile Val Gly Lys Arg 
    130                 135                 140                 


Phe Arg Glu His Phe Pro Glu Ile Leu Lys Lys Ala Ser Glu Gly Leu 
145                 150                 155                 160 


Ser Val Val Phe Gly Leu Glu Leu Asn Lys Val Asn Pro Asn Gly His 
                165                 170                 175     


Thr Tyr Thr Phe Ile Asp Lys Val Asp Leu Thr Asp Glu Glu Ser Leu 
            180                 185                 190         


Leu Ser Ser Trp Asp Phe Pro Arg Arg Lys Leu Leu Met Pro Leu Leu 
        195                 200                 205             


Gly Val Ile Phe Leu Asn Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp 
    210                 215                 220                 


Glu Phe Leu Asn Met Leu Gly Val Tyr Asp Gly Glu Glu His Ser Val 
225                 230                 235                 240 


Phe Gly Glu Pro Trp Lys Leu Ile Thr Lys Asp Leu Val Gln Glu Lys 
                245                 250                 255     


Tyr Leu Glu Tyr Lys Gln Val Pro Ser Ser Asp Pro Pro Arg Phe Gln 
            260                 265                 270         


Phe Leu Trp Gly Pro Arg Ala Tyr Ala Glu Thr Ser Lys Met Lys Val 
        275                 280                 285             


Leu Glu Phe Leu Ala Lys Val Asn Gly Thr Thr Pro Cys Ala Phe Pro 
    290                 295                 300                 


Thr His Tyr Glu Glu Ala Leu Lys Asp Glu Glu Lys Ala Gly Val 
305                 310                 315                 


<210>  2310
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B2__Homo_sapiens__AAD10635

<400>  2310
augccucgug gucagaagag uaagcuccgu gcccgugaga aacgccgcaa ggcccgagau       60

gagacccggg gucucaaugu uccucagguc acugaagcag aggaagaaga ggcccccugc      120

uguuccucuu cuguuucugg gggugcugcu ucaagcucuc cugcugcugg cauuccccag      180

gagccucaga gagccccaac cacugccgcu gcugcggcug cggguguuuc auccacaaaa      240

ucuaaaaaag gugccaagag ccaccaaggu gagaaaaaug caaguuccuc ccaggccuca      300

acauccacua agagcccaag cgaagauccu cuaaccagga agucaggguc guuggugcag      360

uuccuguugu acaaguauaa aauaaaaaag uccguuacaa agggagaaau gcugaaaauu      420

guuggcaaaa gguucaggga gcacuucccu gagauccuca agaaagccuc ugagggccuc      480

aguguugucu uuggccuuga gcugaauaaa gucaacccca acggccacac uuacaccuuc      540

aucgacaagg uagaccucac ugaugaggaa ucccugcuca guuccuggga cuuucccagg      600

agaaagcuuc ugaugccucu ccugggugug aucuucuuaa auggcaacuc agcuacugag      660

gaagagaucu gggaauuccu gaauauguug ggagucuaug auggagagga gcacucaguc      720

uuuggggaac ccuggaagcu caucaccaaa gaucuggugc aggaaaaaua ucuggaguac      780

aagcaggugc ccagcaguga ucccccacgc uuucaauucc uguggggucc gagagccuau      840

gcugaaacca gcaagaugaa aguccuggag uuuuuggcca agguaaaugg uaccaccccc      900

ugugccuucc caacccauua cgaagaagcu uugaaagaug aagagaaagc cggagucuga      960


<210>  2311
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B2__Homo_sapiens__AAD10635

<400>  2311
augccccgcg gccagaaguc caagcugcgg gcccgcgaga agcggcgcaa ggcccgggac       60

gagacccgcg ggcucaacgu gccgcagguc accgaggcgg aggaggagga ggcccccugc      120

ugcagcagcu ccgugagcgg cggggccgcc uccagcuccc ccgccgcggg caucccccag      180

gagccgcagc gggcccccac gaccgccgcc gcggccgccg ccggggugag cuccaccaag      240

agcaagaagg gcgccaaguc ccaccagggc gagaagaacg cgagcuccag ccaggccucc      300

accagcacga agucccccag cgaggacccc cugacccgca aguccgggag ccugguccag      360

uuccuccugu acaaguacaa gaucaagaag uccgugacca agggcgagau gcugaagauc      420

guggggaagc gguuccgcga gcacuucccg gagauccuca agaaggccag cgagggccug      480

agcgucgugu ucgggcugga gcucaacaag gugaacccca acggccacac cuacacguuc      540

aucgacaagg ucgaccugac cgacgaggag ucccugcuca gcuccuggga cuucccccgg      600

cgcaagcugc ugaugccccu ccugggcgug aucuuccuga acgggaacag cgccaccgag      660

gaggagaucu gggaguuccu caacaugcug ggcguguacg acggggagga gcacuccguc      720

uucggcgagc cguggaagcu gaucaccaag gaccucgugc aggagaagua ccuggaguac      780

aagcaggucc ccagcuccga cccgccccgg uuccaguucc uguggggccc ccgcgccuac      840

gcggagacga gcaagaugaa ggugcucgag uuccuggcca aggugaacgg gaccaccccc      900

ugcgccuucc ccacccacua cgaggaggcc cugaaggacg aggagaaggc cggcguguga      960


<210>  2312
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B2__Homo_sapiens__AAD10635

<400>  2312
augccccgcg gccagaaguc caagcuccgc gcccgcgaga agcgccgcaa ggcccgcgac       60

gagacccgcg gccucaacgu cccccagguc accgaggccg aggaggagga ggcccccugc      120

ugcuccuccu ccgucuccgg cggcgccgcc uccuccuccc ccgccgccgg caucccccag      180

gagccccagc gcgcccccac caccgccgcc gccgccgccg ccggcgucuc cuccaccaag      240

uccaagaagg gcgccaaguc ccaccagggc gagaagaacg ccuccuccuc ccaggccucc      300

accuccacca agucccccuc cgaggacccc cucacccgca aguccggcuc ccucguccag      360

uuccuccucu acaaguacaa gaucaagaag uccgucacca agggcgagau gcucaagauc      420

gucggcaagc gcuuccgcga gcacuucccc gagauccuca agaaggccuc cgagggccuc      480

uccgucgucu ucggccucga gcucaacaag gucaacccca acggccacac cuacaccuuc      540

aucgacaagg ucgaccucac cgacgaggag ucccuccucu ccuccuggga cuucccccgc      600

cgcaagcucc ucaugccccu ccucggcguc aucuuccuca acggcaacuc cgccaccgag      660

gaggagaucu gggaguuccu caacaugcuc ggcgucuacg acggcgagga gcacuccguc      720

uucggcgagc ccuggaagcu caucaccaag gaccucgucc aggagaagua ccucgaguac      780

aagcaggucc ccuccuccga ccccccccgc uuccaguucc ucuggggccc ccgcgccuac      840

gccgagaccu ccaagaugaa gguccucgag uuccucgcca aggucaacgg caccaccccc      900

ugcgccuucc ccacccacua cgaggaggcc cucaaggacg aggagaaggc cggcgucuga      960


<210>  2313
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B2__Homo_sapiens__AAD10635

<400>  2313
augcccagag gccagaaaag caaacugagg gcccgggaga agcgccgaaa agcucgugac       60

gaaaccagag ggcucaacgu gccucaaguc acagaggcag aagaggaaga ggccccaugc      120

uguuccucuu caguuagugg aggugcggcu agcuccucuc cggccgcagg caucccccag      180

gagccucaga gggccccaac uacggcugca gccgcugccg cggggguguc gucaaccaag      240

agcaaaaagg gagcaaagag ucaccagggc gaaaagaaug ccuccucuag ccaagcuagu      300

acaucaacua agagucccag cgaggauccu cuuacccgga aaucugguuc ccugguacag      360

uucuuguuau acaaguauaa aauuaagaag ucagugacaa aaggggaaau gcugaagaua      420

gucggaaaac gcuuuagaga gcauuuccca gagauccuaa agaaagccag cgaaggccuc      480

agugugguuu uuggccugga gcuuaacaag gugaauccca acgggcacac cuacacuuuc      540

auugacaaag ucgaucugac agacgaagag ucuuugcucu ccagcuggga uuuuccuagg      600

cggaagcugc ugaugccacu cuuaggagug aucuuccuga augguaacuc ggcaaccgaa      660

gaggagauuu gggaauuucu uaauauguug ggcguauaug acggggagga acauucuguu      720

uucggagagc cguggaagcu gaucacgaaa gaucuagugc aggaaaagua ccucgaguau      780

aaacaggucc ccuccucaga cccuccacgc uuucaauucc uguggggccc ccgagcuuac      840

gccgagacuu ccaagaugaa agugcuugaa uuucuggcga aggugaacgg uaccacaccu      900

ugcgccuucc caacucacua ugaggaagca uugaaggaug aggaaaaagc uggggucuga      960


<210>  2314
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B2__Homo_sapiens__AAD10635

<400>  2314
augcccagag gccagaagag caagcugaga gccagagaga agagaagaaa ggccagagac       60

gagaccagag gccugaacgu gccccaggug accgaggccg aggaggagga ggcccccugc      120

ugcagcagca gcgugagcgg cggcgccgcc agcagcagcc ccgccgccgg caucccccag      180

gagccccaga gagcccccac caccgccgcc gccgccgccg ccggcgugag cagcaccaag      240

agcaagaagg gcgccaagag ccaccagggc gagaagaacg ccagcagcag ccaggccagc      300

accagcacca agagccccag cgaggacccc cugaccagaa agagcggcag ccuggugcag      360

uuccugcugu acaaguacaa gaucaagaag agcgugacca agggcgagau gcugaagauc      420

gugggcaaga gauucagaga gcacuucccc gagauccuga agaaggccag cgagggccug      480

agcguggugu ucggccugga gcugaacaag gugaacccca acggccacac cuacaccuuc      540

aucgacaagg uggaccugac cgacgaggag agccugcuga gcagcuggga cuuccccaga      600

agaaagcugc ugaugccccu gcugggcgug aucuuccuga acggcaacag cgccaccgag      660

gaggagaucu gggaguuccu gaacaugcug ggcguguacg acggcgagga gcacagcgug      720

uucggcgagc ccuggaagcu gaucaccaag gaccuggugc aggagaagua ccuggaguac      780

aagcaggugc ccagcagcga cccccccaga uuccaguucc uguggggccc cagagccuac      840

gccgagacca gcaagaugaa ggugcuggag uuccuggcca aggugaacgg caccaccccc      900

ugcgccuucc ccacccacua cgaggaggcc cugaaggacg aggagaaggc cggcguguga      960


<210>  2315
<211>  960
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B2__Homo_sapiens__AAD10635

<400>  2315
augcccagag gccaaaagag caaacugcgg gcccgcgaga agagacggaa agcucgcgac       60

gaaaccagag ggcucaacgu gccucagguc acagaggccg aagaggaaga ggcgccgugc      120

uguuccucua gcguuuccgg aggcgcugcc ucuagcuccc ccgccgcugg gaucccucag      180

gagccccagc gggccccuac gaccgcugcc gcggccgcug ccggaguguc uagcacaaag      240

uccaaaaagg gcgcuaagag ccaccagggg gaaaagaaug ccucuuccag ccaagcgucu      300

accuccacaa agagccccuc ugaggauccu cugacccgca aauccggaag ccuugugcag      360

uuccugcucu acaaguauaa aauuaagaag uccgucacaa aaggcgaaau gcugaagauc      420

gugggcaaaa gauuucggga gcauuucccg gagauucuua agaaagccuc ugaagggcug      480

agcguugugu uuggacucga gcugaacaag gucaauccca acggccacac cuacacguuc      540

aucgacaaag uggaucugac cgacgaagag ucccuccuga gcucuuggga uuuuccucgc      600

agaaaacuuc ugaugccccu ccuggggguu auuuuccuua auggaaacuc cgcuacagaa      660

gaggagaucu gggaauuucu gaauaugcuc ggcguguaug acggggagga acauagcguc      720

uucggagagc cuuggaagcu gaucaccaaa gaucuggugc aggaaaagua ccucgaguau      780

aaacaggugc ccucuagcga cccgccucgg uuucaauucc uguggggccc ccgcgccuac      840

gcugagacau ccaagaugaa aguccuugaa uuucuggcca agguuaacgg caccacgccu      900

ugcgccuucc ccacacacua ugaggaagcu cucaaggaug aggaaaaagc ggggguguga      960


<210>  2316
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B3__Homo_sapiens__O15480

<400>  2316

Met Pro Arg Gly Gln Lys Ser Thr Leu His Ala Arg Glu Lys Arg Gln 
1               5                   10                  15      


Gln Thr Arg Gly Gln Thr Gln Asp His Gln Gly Ala Gln Ile Thr Ala 
            20                  25                  30          


Thr Asn Lys Lys Lys Val Ser Phe Ser Ser Pro Leu Ile Leu Gly Ala 
        35                  40                  45              


Thr Ile Gln Lys Lys Ser Ala Gly Arg Ser Arg Ser Ala Leu Lys Lys 
    50                  55                  60                  


Pro Gln Arg Ala Leu Ser Thr Thr Thr Ser Val Asp Val Ser Tyr Lys 
65                  70                  75                  80  


Lys Ser Tyr Lys Gly Ala Asn Ser Lys Ile Glu Lys Lys Gln Ser Phe 
                85                  90                  95      


Ser Gln Gly Leu Ser Ser Thr Val Gln Ser Arg Thr Asp Pro Leu Ile 
            100                 105                 110         


Met Lys Thr Asn Met Leu Val Gln Phe Leu Met Glu Met Tyr Lys Met 
        115                 120                 125             


Lys Lys Pro Ile Met Lys Ala Asp Met Leu Lys Ile Val Gln Lys Ser 
    130                 135                 140                 


His Lys Asn Cys Phe Pro Glu Ile Leu Lys Lys Ala Ser Phe Asn Met 
145                 150                 155                 160 


Glu Val Val Phe Gly Val Asp Leu Lys Lys Val Asp Ser Thr Lys Asp 
                165                 170                 175     


Ser Tyr Val Leu Val Ser Lys Met Asp Leu Pro Asn Asn Gly Thr Val 
            180                 185                 190         


Thr Arg Gly Arg Gly Phe Pro Lys Thr Gly Leu Leu Leu Asn Leu Leu 
        195                 200                 205             


Gly Val Ile Phe Met Lys Gly Asn Cys Ala Thr Glu Glu Lys Ile Trp 
    210                 215                 220                 


Glu Phe Leu Asn Lys Met Arg Ile Tyr Asp Gly Lys Lys His Phe Ile 
225                 230                 235                 240 


Phe Gly Glu Pro Arg Lys Leu Ile Thr Gln Asp Leu Val Lys Leu Lys 
                245                 250                 255     


Tyr Leu Glu Tyr Arg Gln Val Pro Asn Ser Asn Pro Ala Arg Tyr Glu 
            260                 265                 270         


Phe Leu Trp Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val 
        275                 280                 285             


Leu Glu Phe Trp Ala Lys Val Asn Lys Thr Val Pro Ser Ala Phe Gln 
    290                 295                 300                 


Phe Trp Tyr Glu Glu Ala Leu Arg Asp Glu Glu Glu Arg Val Gln Ala 
305                 310                 315                 320 


Ala Ala Met Leu Asn Asp Gly Ser Ser Ala Met Gly Arg Lys Cys Ser 
                325                 330                 335     


Lys Ala Lys Ala Ser Ser Ser Ser His Ala 
            340                 345     


<210>  2317
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B3__Homo_sapiens__AAD10636

<400>  2317
augccucggg gucagaagag uacgcuccau gcacgugaga aacgccagca gacccggggu       60

cagacccagg aucaccaggg ugcucagauc acugcaacua acaagaaaaa aguauccuuu      120

ucauccccuc uuauuuuggg ggcuacuauc cagaaaaagu cugcugguag gucacguagu      180

gcucucaaga agccucagag agcacuaucc accacuacau cuguagaugu uucuuacaaa      240

aagucauaca agggagccaa cagcaaaauu gagaaaaagc aaagcuucuc ucagggucua      300

uccuccacug ugcagucucg cacagacccu cuaaucauga agacaaauau guuggugcag      360

uuccugaugg aaauguacaa gaugaaaaag cccauuauga aagcagauau gcuaaaaauu      420

guccaaaaaa gccauaagaa uugcuucccu gagauccuua aaaaagcuuc uuucaacaug      480

gaggugguau uugguguuga uuuaaagaaa guugauucua ccaaggacuc cuauguccuu      540

gucagcaaaa uggaucuccc caacaauggg acagugacuc gugggagggg auuucccaag      600

acaggucucc ugcugaaucu ccugggcgug aucuucauga agggcaacug ugccacugag      660

gagaagaucu gggaauuccu gaauaagaug agaauauaug augggaagaa acacuucaua      720

uuuggggagc ccagaaagcu caucacccaa gauuugguga agcuuaaaua ccuggaguac      780

cgacaagugc ccaacaguaa uccugcacgc uaugaauucc uguggggucc aagagcccau      840

gcugaaacca gcaagaugaa gguccuggag uuuugggcca aggucaauaa aacugucccc      900

agugcguucc aguucuggua ugaagaggcu uugagagaug aggaagaaag aguccaagcu      960

gcagcuaugc ucaaugaugg caguagugcc augggcagaa aguguuccaa ggccaaggcu     1020

agcagcucuu cccacgccua g                                               1041


<210>  2318
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B3__Homo_sapiens__AAD10636

<400>  2318
augccccgcg gccagaaguc cacccugcac gcccgggaga agcgccagca gacccggggg       60

cagacgcagg accaccaggg cgcccagauc accgcgacca acaagaagaa ggugagcuuc      120

agcuccccgc ucauccuggg ggccaccauc cagaagaagu ccgccggccg cagccggagc      180

gcccugaaga agccccagcg cgcccucucc acgaccacca gcgucgacgu guccuacaag      240

aaguccuaca agggggcgaa cagcaagauc gagaagaagc agagcuucuc ccagggccug      300

agcuccaccg ugcagagccg gacggacccc cugaucauga agaccaacau gcucguccag      360

uuccugaugg agauguacaa gaugaagaag cccaucauga aggccgacau gcugaagauc      420

gugcagaagu cccacaagaa cugcuucccg gagauccuca agaaggccag cuucaacaug      480

gagguggucu ucggcgugga ccugaagaag guggacucca ccaaggacag cuacguccug      540

gugagcaaga uggaccuccc caacaacggg accgugacgc gcggccgggg guuccccaag      600

accggccugc ugcucaaccu gcuggggguc aucuucauga agggcaacug cgccaccgag      660

gagaagaucu gggaguuccu caacaagaug cgcaucuacg acggcaagaa gcacuucauc      720

uucggggagc cccggaagcu gaucacccag gaccugguga agcucaagua ccuggaguac      780

cgccaggugc cgaacuccaa ccccgcgcgg uacgaguucc uguggggccc ccgcgcccac      840

gccgagacga gcaagaugaa gguccucgag uucugggcca aggugaacaa gaccgugccc      900

uccgccuucc aguucuggua cgaggaggcg cugcgggacg aggaggagcg cguccaggcc      960

gccgccaugc ugaacgacgg gagcuccgcc augggccgga agugcagcaa ggcgaaggcc     1020

uccagcucca gccacgccug a                                               1041


<210>  2319
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B3__Homo_sapiens__AAD10636

<400>  2319
augccccgcg gccagaaguc cacccuccac gcccgcgaga agcgccagca gacccgcggc       60

cagacccagg accaccaggg cgcccagauc accgccacca acaagaagaa ggucuccuuc      120

uccucccccc ucauccucgg cgccaccauc cagaagaagu ccgccggccg cucccgcucc      180

gcccucaaga agccccagcg cgcccucucc accaccaccu ccgucgacgu cuccuacaag      240

aaguccuaca agggcgccaa cuccaagauc gagaagaagc aguccuucuc ccagggccuc      300

uccuccaccg uccagucccg caccgacccc cucaucauga agaccaacau gcucguccag      360

uuccucaugg agauguacaa gaugaagaag cccaucauga aggccgacau gcucaagauc      420

guccagaagu cccacaagaa cugcuucccc gagauccuca agaaggccuc cuucaacaug      480

gaggucgucu ucggcgucga ccucaagaag gucgacucca ccaaggacuc cuacguccuc      540

gucuccaaga uggaccuccc caacaacggc accgucaccc gcggccgcgg cuuccccaag      600

accggccucc uccucaaccu ccucggcguc aucuucauga agggcaacug cgccaccgag      660

gagaagaucu gggaguuccu caacaagaug cgcaucuacg acggcaagaa gcacuucauc      720

uucggcgagc cccgcaagcu caucacccag gaccucguca agcucaagua ccucgaguac      780

cgccaggucc ccaacuccaa ccccgcccgc uacgaguucc ucuggggccc ccgcgcccac      840

gccgagaccu ccaagaugaa gguccucgag uucugggcca aggucaacaa gaccgucccc      900

uccgccuucc aguucuggua cgaggaggcc cuccgcgacg aggaggagcg cguccaggcc      960

gccgccaugc ucaacgacgg cuccuccgcc augggccgca agugcuccaa ggccaaggcc     1020

uccuccuccu cccacgccug a                                               1041


<210>  2320
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B3__Homo_sapiens__AAD10636

<400>  2320
augcccagag gccaaaagag cacccugcac gccagggaga aacggcaaca gacacgcggg       60

cagacucagg accaucaagg agcucagauc acggcaacca acaagaaaaa gguguccuuc      120

ucuucaccuc ucauucuugg ugccacaaua cagaaaaaga gugcgggccg aagccguucc      180

gcucugaaga aaccacagag agccuugucu acuaccacau cggucgaugu uucauacaag      240

aaaagcuaua agggggcaaa uaguaaaauc gaaaagaagc aauccuuuuc ucagggauua      300

agcuccaccg ugcagucaag gacugacccg cugauuauga aaacaaacau gcuaguacag      360

uuccucaugg agauguacaa gaugaaaaag cccaucauga aagccgauau gcugaagauu      420

gugcagaaaa gucacaagaa uugcuuuccu gaaauccuua agaaagcuag cuucaacaug      480

gaggucgugu uuggcguuga ccugaagaaa guggauucua ccaaggacuc cuaugucuug      540

gugucaaaaa uggaucuccc aaauaacggu acgguaacuc gggggcgcgg auuccccaag      600

accggccugc ugcucaauuu acugggcguu auauuuauga aggggaacug ugcaacagaa      660

gagaaaaucu gggaguuccu uaauaagaug agaauuuacg acgguaaaaa gcauuuuauc      720

uucggagaac cuaggaaauu gauuacucag gaucugguga agcuaaagua ucucgaguac      780

cggcaggucc caaacagcaa ucccgcccgc uaugaauuuc uguggggccc ucgagcucac      840

gccgagacca guaaaaugaa ggugcuugag uucugggcga aagugaacaa gacaguccca      900

ucugcauuuc aauucuggua cgaagaggcc cugagagacg aagaggaaag gguucaggcu      960

gccgcaaugu ugaaugaugg guccagcgcu augggacgga aaugcucgaa ggccaaggcg     1020

ucuuccucaa gucaugccug a                                               1041


<210>  2321
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B3__Homo_sapiens__AAD10636

<400>  2321
augcccagag gccagaagag cacccugcac gccagagaga agagacagca gaccagaggc       60

cagacccagg accaccaggg cgcccagauc accgccacca acaagaagaa ggugagcuuc      120

agcagccccc ugauccuggg cgccaccauc cagaagaaga gcgccggcag aagcagaagc      180

gcccugaaga agccccagag agcccugagc accaccacca gcguggacgu gagcuacaag      240

aagagcuaca agggcgccaa cagcaagauc gagaagaagc agagcuucag ccagggccug      300

agcagcaccg ugcagagcag aaccgacccc cugaucauga agaccaacau gcuggugcag      360

uuccugaugg agauguacaa gaugaagaag cccaucauga aggccgacau gcugaagauc      420

gugcagaaga gccacaagaa cugcuucccc gagauccuga agaaggccag cuucaacaug      480

gagguggugu ucggcgugga ccugaagaag guggacagca ccaaggacag cuacgugcug      540

gugagcaaga uggaccugcc caacaacggc accgugacca gaggcagagg cuuccccaag      600

accggccugc ugcugaaccu gcugggcgug aucuucauga agggcaacug cgccaccgag      660

gagaagaucu gggaguuccu gaacaagaug agaaucuacg acggcaagaa gcacuucauc      720

uucggcgagc ccagaaagcu gaucacccag gaccugguga agcugaagua ccuggaguac      780

agacaggugc ccaacagcaa ccccgccaga uacgaguucc uguggggccc cagagcccac      840

gccgagacca gcaagaugaa ggugcuggag uucugggcca aggugaacaa gaccgugccc      900

agcgccuucc aguucuggua cgaggaggcc cugagagacg aggaggagag agugcaggcc      960

gccgccaugc ugaacgacgg cagcagcgcc augggcagaa agugcagcaa ggccaaggcc     1020

agcagcagca gccacgccug a                                               1041


<210>  2322
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B3__Homo_sapiens__AAD10636

<400>  2322
augcccagag gccaaaagag cacccugcac gcccgggaga aacgccaaca gacaagaggg       60

cagacgcagg accaucaagg agcucagauc accgccacaa acaagaaaaa gguguccuuc      120

ucuagcccuc ucauucuggg cgcgaccauc cagaaaaagu ccgcugggcg gucucgcagc      180

gcccuuaaga aaccgcagag agcccugucc acaaccacau cugucgaugu uagcuacaag      240

aaauccuaua agggagcuaa uagcaaaauu gaaaagaagc aaucuuuuuc ccagggccuc      300

agcucuaccg ugcagucccg gacggacccc cugaucauga aaaccaacau gcuugugcag      360

uuccugaugg agauguacaa gaugaaaaag ccuauuauga aagccgauau gcucaagauc      420

guccagaaaa gccacaagaa uugcuuuccc gaaauccuga agaaagccuc uuucaacaug      480

gaggugguuu uuggggugga ccugaagaaa gucgauucca caaaggacag cuaugugcuc      540

guuuccaaaa uggaucugcc uaauaacgga accgugacac gcggcagagg cuuccccaag      600

accgggcuuc ugcucaaucu gcuuggaguc auuuuuauga agggcaacug ugcuacggaa      660

gagaaaaucu gggaguuccu gaauaagaug cggauuuacg acgggaaaaa gcauuuuauc      720

uucggagaac cucgcaaacu cauuacacag gaucugguga agcugaagua ucucgaguac      780

agacaggugc cgaacucuaa ucccgcgcgg uaugaauuuc uguggggccc ucgcgcccac      840

gcugagacca gcaaaaugaa gguccuugag uucugggcca aaguuaacaa gacagugccc      900

uccgcuuuuc aauucuggua cgaagaggcc cugagagacg aagaggaacg ggugcaggcg      960

gccgcuaugc ucaaugaugg gagcucugcc augggacgca aaugcuccaa ggcuaaggcc     1020

agcucuagcu cccaugccug a                                               1041


<210>  2323
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B4__Homo_sapiens__O15481

<400>  2323

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Gln 
1               5                   10                  15      


Arg Thr Arg Gly Gln Thr Gln Asp Leu Lys Val Gly Gln Pro Thr Ala 
            20                  25                  30          


Ala Glu Lys Glu Glu Ser Pro Ser Ser Ser Ser Ser Val Leu Arg Asp 
        35                  40                  45              


Thr Ala Ser Ser Ser Leu Ala Phe Gly Ile Pro Gln Glu Pro Gln Arg 
    50                  55                  60                  


Glu Pro Pro Thr Thr Ser Ala Ala Ala Ala Met Ser Cys Thr Gly Ser 
65                  70                  75                  80  


Asp Lys Gly Asp Glu Ser Gln Asp Glu Glu Asn Ala Ser Ser Ser Gln 
                85                  90                  95      


Ala Ser Thr Ser Thr Glu Arg Ser Leu Lys Asp Ser Leu Thr Arg Lys 
            100                 105                 110         


Thr Lys Met Leu Val Gln Phe Leu Leu Tyr Lys Tyr Lys Met Lys Glu 
        115                 120                 125             


Pro Thr Thr Lys Ala Glu Met Leu Lys Ile Ile Ser Lys Lys Tyr Lys 
    130                 135                 140                 


Glu His Phe Pro Glu Ile Phe Arg Lys Val Ser Gln Arg Thr Glu Leu 
145                 150                 155                 160 


Val Phe Gly Leu Ala Leu Lys Glu Val Asn Pro Thr Thr His Ser Tyr 
                165                 170                 175     


Ile Leu Val Ser Met Leu Gly Pro Asn Asp Gly Asn Gln Ser Ser Ala 
            180                 185                 190         


Trp Thr Leu Pro Arg Asn Gly Leu Leu Met Pro Leu Leu Ser Val Ile 
        195                 200                 205             


Phe Leu Asn Gly Asn Cys Ala Arg Glu Glu Glu Ile Trp Glu Phe Leu 
    210                 215                 220                 


Asn Met Leu Gly Ile Tyr Asp Gly Lys Arg His Leu Ile Phe Gly Glu 
225                 230                 235                 240 


Pro Arg Lys Leu Ile Thr Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu 
                245                 250                 255     


Tyr Gln Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln Phe Leu Trp 
            260                 265                 270         


Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val Leu Glu Phe 
        275                 280                 285             


Leu Ala Lys Val Asn Asp Thr Thr Pro Asn Asn Phe Pro Leu Leu Tyr 
    290                 295                 300                 


Glu Glu Ala Leu Arg Asp Glu Glu Glu Arg Ala Gly Ala Arg Pro Arg 
305                 310                 315                 320 


Val Ala Ala Arg Arg Gly Thr Thr Ala Met Thr Ser Ala Tyr Ser Arg 
                325                 330                 335     


Ala Thr Ser Ser Ser Ser Ser Gln Pro Met 
            340                 345     


<210>  2324
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B4__Homo_sapiens__AAC23619

<400>  2324
augccucggg gucagaagag uaagcuccgu gcccgugaga aacgccagcg gacccguggu       60

cagacccagg aucucaaggu uggucagccu acugcagcag agaaagaaga gucuccuucc      120

ucuuccucau cuguuuugag ggauacugcc uccagcuccc uugcuuuugg cauuccccag      180

gagccucaga gagagccacc caccaccucu gcugcugcag cuaugucaug cacuggaucu      240

gauaaaggcg acgagagcca agaugaggaa aaugcaaguu ccucccaggc cucaacaucc      300

acugagagau cacucaaaga uucucuaacc aggaagacga agauguuagu gcaguuccug      360

cuguacaagu auaaaaugaa agagcccacu acaaaggcag aaaugcugaa gaucaucagc      420

aaaaaguaca aggagcacuu cccugagauc uucaggaaag ucucucagcg cacggagcug      480

gucuuuggcc uugccuugaa ggaggucaac cccaccacuc acuccuacau ccucgucagc      540

augcuaggcc ccaacgaugg aaaccagagc agugccugga cccuuccaag gaaugggcuu      600

cugaugccuc uacugagugu gaucuucuua aauggcaacu gugcccguga agaggaaauc      660

ugggaauucc ugaauaugcu ggggaucuau gauggaaaga ggcaccuuau cuuuggggaa      720

ccccgaaagc ucaucaccca agaucuggug caggaaaaau aucuggaaua ccagcaggug      780

cccaacagug aucccccacg cuaucaauuc cugugggguc caagagcuca ugcagaaacc      840

agcaagauga aaguccugga guuuuuggcc aaggugaaug acaccacccc caauaacuuc      900

ccacuccuuu augaagaggc uuugagagau gaagaagaga gagcuggagc ccggcccaga      960

guugcagcca ggcguggcac uacagccaug acuagugcgu auuccagggc cacauccagu     1020

agcucuuccc aacccaugug a                                               1041


<210>  2325
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B4__Homo_sapiens__AAC23619

<400>  2325
augccccgcg gccagaaguc caagcugcgg gcccgcgaga agcggcagcg cacccggggg       60

cagacccagg accucaaggu gggccagccg acggccgcgg agaaggagga gagccccagc      120

uccagcucca gcguccugcg cgacaccgcc uccagcuccc uggccuucgg gaucccccag      180

gagccccagc gggagccgcc caccaccagc gccgccgcgg ccauguccug cacgggcagc      240

gacaaggggg acgaguccca ggacgaggag aacgccagcu ccagccaggc cuccaccagc      300

accgagcgcu cccucaagga cagccugacc cggaagacga agaugcuggu gcaguuccuc      360

cuguacaagu acaagaugaa ggagcccacc accaaggcgg agaugcugaa gaucaucagc      420

aagaaguaca aggagcacuu ccccgagauc uuccgcaagg ugucccagcg gaccgagcuc      480

gucuucggcc uggcccugaa ggaggugaac ccgacgaccc acagcuacau ccucgugucc      540

augcugggcc ccaacgacgg gaaccagagc uccgccugga cccugccccg caacggccuc      600

cugaugcccc ugcucagcgu caucuuccug aacgggaacu gcgcccggga ggaggagauc      660

ugggaguucc ugaacaugcu cggcaucuac gacgggaagc gccaccugau cuucggcgag      720

ccgcggaagc ugaucaccca ggaccucgug caggagaagu accuggagua ccagcagguc      780

cccaacuccg acccgccccg cuaccaguuc cuguggggcc cccgggccca cgcggagacg      840

agcaagauga aggugcucga guuccuggcc aaggugaacg acaccacccc caacaacuuc      900

ccccugcucu acgaggaggc ccugcgcgac gaggaggagc gggccggggc ccgcccccgg      960

guggcggccc gccgcggcac cacggccaug accuccgccu acagccgggc caccuccagc     1020

uccagcuccc agccgaugug a                                               1041


<210>  2326
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B4__Homo_sapiens__AAC23619

<400>  2326
augccccgcg gccagaaguc caagcuccgc gcccgcgaga agcgccagcg cacccgcggc       60

cagacccagg accucaaggu cggccagccc accgccgccg agaaggagga gucccccucc      120

uccuccuccu ccguccuccg cgacaccgcc uccuccuccc ucgccuucgg caucccccag      180

gagccccagc gcgagccccc caccaccucc gccgccgccg ccauguccug caccggcucc      240

gacaagggcg acgaguccca ggacgaggag aacgccuccu ccucccaggc cuccaccucc      300

accgagcgcu cccucaagga cucccucacc cgcaagacca agaugcucgu ccaguuccuc      360

cucuacaagu acaagaugaa ggagcccacc accaaggccg agaugcucaa gaucaucucc      420

aagaaguaca aggagcacuu ccccgagauc uuccgcaagg ucucccagcg caccgagcuc      480

gucuucggcc ucgcccucaa ggaggucaac cccaccaccc acuccuacau ccucgucucc      540

augcucggcc ccaacgacgg caaccagucc uccgccugga cccucccccg caacggccuc      600

cucaugcccc uccucuccgu caucuuccuc aacggcaacu gcgcccgcga ggaggagauc      660

ugggaguucc ucaacaugcu cggcaucuac gacggcaagc gccaccucau cuucggcgag      720

ccccgcaagc ucaucaccca ggaccucguc caggagaagu accucgagua ccagcagguc      780

cccaacuccg accccccccg cuaccaguuc cucuggggcc cccgcgccca cgccgagacc      840

uccaagauga agguccucga guuccucgcc aaggucaacg acaccacccc caacaacuuc      900

ccccuccucu acgaggaggc ccuccgcgac gaggaggagc gcgccggcgc ccgcccccgc      960

gucgccgccc gccgcggcac caccgccaug accuccgccu acucccgcgc caccuccucc     1020

uccuccuccc agcccaugug a                                               1041


<210>  2327
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B4__Homo_sapiens__AAC23619

<400>  2327
augcccagag gccaaaagag caaacugagg gcccgggaga agcgccagcg aacccguggg       60

cagacacagg accucaaagu gggacagccu acugcugcag aaaaggagga auccccaucu      120

ucaaguagcu ccguccuuag agauacggcc ucuucgucac uggcguucgg uaucccgcaa      180

gagccccaga gggaaccucc aaccacaagc gcugccgcag ccaugaguug cacuggcucc      240

gacaaagggg augagucuca ggacgaggaa aacgcuagcu ccucacaggc aaguaccagc      300

acagagcggu cuuugaagga uuccuuaacc cgcaagacua aaaugcuggu ucaauuucua      360

cucuacaagu auaaaaugaa ggaacccaca accaaagccg agaugcugaa gauuauauca      420

aagaaauaca aggagcacuu cccugaaauc uuuagaaaag ugagccagag gacggagcuu      480

guauucggac uggcuuugaa ggaagugaau ccaacuaccc auaguuauau ucucgucucu      540

augcugggcc ccaacgacgg uaaucagucc agcgccugga cacugccucg gaacgggcuc      600

uuaaugccac ugcuuucggu gaucuuuuug aauggaaacu gugcgcgcga ggaagagauu      660

ugggaguucc ugaauaugcu aggcaucuac gauggcaaac gacaccucau auuuggggaa      720

ccgagaaagc ugaucacuca ggaccuuguu caagagaaau aucuggaaua ccaacaggug      780

cccaacucug auccuccaag guaucaguuc uuguggggac cccgggcaca ugccgagacc      840

uccaagauga agguccucga auuucuggcu aaagugaaug acacaacccc uaacaauuuc      900

ccauuacugu acgaggaggc ccuccgugau gaagaggaac gcgcuggugc aagacccagg      960

guagccgcgc ggcgaggcac gacugccaug acaucagcau acagucgcgc uaccagcucc     1020

ucuagcucac agccgaugug a                                               1041


<210>  2328
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B4__Homo_sapiens__AAC23619

<400>  2328
augcccagag gccagaagag caagcugaga gccagagaga agagacagag aaccagaggc       60

cagacccagg accugaaggu gggccagccc accgccgccg agaaggagga gagccccagc      120

agcagcagca gcgugcugag agacaccgcc agcagcagcc uggccuucgg caucccccag      180

gagccccaga gagagccccc caccaccagc gccgccgccg ccaugagcug caccggcagc      240

gacaagggcg acgagagcca ggacgaggag aacgccagca gcagccaggc cagcaccagc      300

accgagagaa gccugaagga cagccugacc agaaagacca agaugcuggu gcaguuccug      360

cuguacaagu acaagaugaa ggagcccacc accaaggccg agaugcugaa gaucaucagc      420

aagaaguaca aggagcacuu ccccgagauc uucagaaagg ugagccagag aaccgagcug      480

guguucggcc uggcccugaa ggaggugaac cccaccaccc acagcuacau ccuggugagc      540

augcugggcc ccaacgacgg caaccagagc agcgccugga cccugcccag aaacggccug      600

cugaugcccc ugcugagcgu gaucuuccug aacggcaacu gcgccagaga ggaggagauc      660

ugggaguucc ugaacaugcu gggcaucuac gacggcaaga gacaccugau cuucggcgag      720

cccagaaagc ugaucaccca ggaccuggug caggagaagu accuggagua ccagcaggug      780

cccaacagcg acccccccag auaccaguuc cuguggggcc ccagagccca cgccgagacc      840

agcaagauga aggugcugga guuccuggcc aaggugaacg acaccacccc caacaacuuc      900

ccccugcugu acgaggaggc ccugagagac gaggaggaga gagccggcgc cagacccaga      960

guggccgcca gaagaggcac caccgccaug accagcgccu acagcagagc caccagcagc     1020

agcagcagcc agcccaugug a                                               1041


<210>  2329
<211>  1041
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B4__Homo_sapiens__AAC23619

<400>  2329
augcccagag gccagaaguc uaaacugcgg gcccgcgaga agagacaacg gacccgcggg       60

cagacacagg accucaaagu gggacagccu acggcugccg aaaaggagga auccccgucu      120

agcuccucua gcguccugag agauaccgcg uccucuagcc uugcuuucgg caucccccaa      180

gagccucagc gggaaccccc uacaaccucc gccgccgcug ccaugagcug cacagggucu      240

gacaaaggag augaguccca ggacgaggaa aacgcuagca gcucccaggc cagcaccucu      300

acagagcgcu cccugaagga uagccucacc agaaagacga aaaugcuggu ucaauuucuu      360

cuguacaagu auaaaaugaa ggaacccacc acaaaagcgg agaugcucaa gauuaucucc      420

aagaaauaca aggagcacuu cccugaaauu uuucggaaag ugucucagcg caccgagcug      480

guguucggcc uggcccucaa ggaagucaau ccgacaaccc auagcuauau ccuggugucc      540

augcuugggc ccaacgacgg aaaucagagc ucugcuugga cgcugccuag aaacggccuc      600

cugaugcccc uucuguccgu uauuuuucuc aauggcaacu gugcccggga ggaagagauc      660

ugggaguucc ugaauaugcu ggggaucuac gauggaaaac gccaccucau uuuuggcgaa      720

ccuagaaagc ugaucacaca ggaccuugug caagagaaau aucuggaaua ccagcagguc      780

cccaacagcg auccgccucg guaucaauuc cucugggggc cccgcgcuca ugccgagacc      840

ucuaagauga aggugcugga auuucuugcg aaaguuaaug acacaacccc uaacaauuuc      900

ccccugcucu acgaggaggc ccugagagau gaagaggaac gggcuggagc cagaccccgc      960

guggcugccc ggagaggcac cacagccaug acgagcgcuu acucccgcgc gaccucuagc     1020

uccagcucuc agccuaugug a                                               1041


<210>  2330
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B5__Homo_sapiens__Q9BZ81

<400>  2330

Met Thr Ser Ala Gly Val Phe Asn Ala Gly Ser Asp Glu Arg Ala Asn 
1               5                   10                  15      


Ser Arg Asp Glu Glu Tyr Pro Cys Ser Ser Glu Val Ser Pro Ser Thr 
            20                  25                  30          


Glu Ser Ser Cys Ser Asn Phe Ile Asn Ile Lys Val Gly Leu Leu Glu 
        35                  40                  45              


Gln Phe Leu Leu Tyr Lys Phe Lys Met Lys Gln Arg Ile Leu Lys Glu 
    50                  55                  60                  


Asp Met Leu Lys Ile Val Asn Pro Arg Tyr Gln Asn Gln Phe Ala Glu 
65                  70                  75                  80  


Ile His Arg Arg Ala Ser Glu His Ile Glu Val Val Phe Ala Val Asp 
                85                  90                  95      


Leu Lys Glu Val Asn Pro Thr Cys His Leu Tyr Asp Leu Val Ser Lys 
            100                 105                 110         


Leu Lys Leu Pro Asn Asn Gly Arg Ile His Val Gly Lys Val Leu Pro 
        115                 120                 125             


Lys Thr Gly Leu Leu Met Thr Phe Leu Val Val Ile Phe Leu Lys Gly 
    130                 135                 140                 


Asn Cys Ala Asn Lys Glu Asp Thr Trp Lys Phe Leu Asp Met Met Gln 
145                 150                 155                 160 


Ile Tyr Asp Gly Lys Lys Tyr Tyr Ile Tyr Gly Glu Pro Arg Lys Leu 
                165                 170                 175     


Ile Thr Gln Asp Phe Val Arg Leu Thr Tyr Leu Glu Tyr His Gln Val 
            180                 185                 190         


Pro Cys Ser Tyr Pro Ala His Tyr Gln Phe Leu Trp Gly Pro Arg Ala 
        195                 200                 205             


Tyr Thr Glu Thr Ser Lys Met Lys Val Leu Glu Tyr Leu Ala Lys Val 
    210                 215                 220                 


Asn Asp Ile Ala Pro Gly Ala Phe Ser Ser Gln Tyr Glu Glu Ala Leu 
225                 230                 235                 240 


Gln Asp Glu Glu Glu Ser Pro Ser Gln Arg Cys Ser Arg Asn Trp His 
                245                 250                 255     


Tyr Cys Ser Gly Gln Asp Cys Leu Arg Ala Lys Phe Ser Ser Phe Ser 
            260                 265                 270         


Gln Pro Tyr 
        275 


<210>  2331
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2331
augacuucug cagguguuuu uaaugcagga ucugacgaaa gggcuaacag uagagaugag       60

gaguacccau guuccucaga ggucucaccc uccacugaga guucaugcag caauuucaua      120

aauauuaagg uggguuuguu ggagcaguuc cugcucuaca aguucaaaau gaaacagcgu      180

auuuugaagg aagauaugcu gaagauuguc aacccaagau accaaaacca guuugcugag      240

auucacagaa gagcuucuga gcacauugag guugucuuug caguugacuu gaaggaaguc      300

aacccaacuu gucacuuaua ugaccuuguc agcaagcuga aacuccccaa caaugggagg      360

auucauguug gcaaaguguu acccaagacu ggucuccuca ugacuuuccu gguugugauc      420

uuccugaaag gcaacugugc caacaaggaa gauaccugga aauuucugga uaugaugcaa      480

auauaugaug ggaagaagua cuacaucuau ggagagccca ggaagcucau cacucaggau      540

uucgugaggc uaacguaccu ggaguaccac caggugcccu gcaguuaucc ugcacacuau      600

caauuccuuu gggguccaag agccuauacu gaaaccagca agaugaaagu ccuggaauau      660

uuggccaagg ucaaugauau ugcuccaggu gccuucucau cacaauauga agaggcuuug      720

caagaugagg aagagagccc aagccagaga ugcagccgaa acuggcacua cugcaguggc      780

caagacuguc ucagggcgaa guucagcagc uucucucaac ccuauuga                   828


<210>  2332
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2332
augaccagcg ccggcguguu caacgccggg uccgacgagc gcgcgaacag ccgggacgag       60

gaguaccccu gcuccagcga ggucuccccg agcaccgagu ccagcugcuc caacuucauc      120

aacaucaagg ugggccugcu cgagcaguuc cugcuguaca aguucaagau gaagcagcgc      180

auccucaagg aggacaugcu gaagaucgug aacccccggu accagaacca guucgccgag      240

auccaccgcc gggccagcga gcacaucgag gucguguucg ccguggaccu gaaggagguc      300

aaccccacgu gccaccucua cgaccuggug uccaagcuga agcuccccaa caacgggcgc      360

auccacgugg gcaagguccu gccgaagacc gggcugcuca ugaccuuccu gguggugauc      420

uuccugaagg gcaacugcgc caacaaggag gacaccugga aguuccucga caugaugcag      480

aucuacgacg gcaagaagua cuacaucuac ggggagcccc ggaagcugau cacgcaggac      540

uucguccgcc ugaccuaccu cgaguaccac caggugcccu gcagcuaccc cgcgcacuac      600

caguuccugu ggggcccgcg ggccuacacc gagaccucca agaugaaggu gcuggaguac      660

cucgccaagg ucaacgacau cgcccccggg gcguucagcu cccaguacga ggaggcccug      720

caggacgagg aggagagccc cucccagcgc ugcagccgga acuggcacua cugcuccggc      780

caggacugcc ugcgcgccaa guucagcagc uucucccagc ccuacuga                   828


<210>  2333
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2333
augaccuccg ccggcgucuu caacgccggc uccgacgagc gcgccaacuc ccgcgacgag       60

gaguaccccu gcuccuccga ggucuccccc uccaccgagu ccuccugcuc caacuucauc      120

aacaucaagg ucggccuccu cgagcaguuc cuccucuaca aguucaagau gaagcagcgc      180

auccucaagg aggacaugcu caagaucguc aacccccgcu accagaacca guucgccgag      240

auccaccgcc gcgccuccga gcacaucgag gucgucuucg ccgucgaccu caaggagguc      300

aaccccaccu gccaccucua cgaccucguc uccaagcuca agcuccccaa caacggccgc      360

auccacgucg gcaagguccu ccccaagacc ggccuccuca ugaccuuccu cgucgucauc      420

uuccucaagg gcaacugcgc caacaaggag gacaccugga aguuccucga caugaugcag      480

aucuacgacg gcaagaagua cuacaucuac ggcgagcccc gcaagcucau cacccaggac      540

uucguccgcc ucaccuaccu cgaguaccac cagguccccu gcuccuaccc cgcccacuac      600

caguuccucu ggggcccccg cgccuacacc gagaccucca agaugaaggu ccucgaguac      660

cucgccaagg ucaacgacau cgcccccggc gccuucuccu cccaguacga ggaggcccuc      720

caggacgagg aggagucccc cucccagcgc ugcucccgca acuggcacua cugcuccggc      780

caggacugcc uccgcgccaa guucuccucc uucucccagc ccuacuga                   828


<210>  2334
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2334
augaccagcg ccggcguguu caacgcuggg uccgacgaga gagcaaauuc uagggaugaa       60

gaguaccccu gcucaaguga agucagcccu uccacagagu cuucguguuc aaacuuuauc      120

aauauuaagg uuggacugcu cgaacaguuc cuucuguaua aauuuaagau gaaacaacgg      180

auauugaagg aggacauguu aaaaaucgug aacccacgcu accagaauca guucgccgag      240

auucaccgac gugcgagcga acauaucgag guaguguuug cugucgaucu gaaggaagug      300

aacccgacuu gccaccuaua ugaccucguu aguaagcuga aacuucccaa uaacgguagg      360

auucaugugg gcaagguccu gccuaaaacg ggguugcuca ugaccuuccu ggugguaauc      420

uuucugaagg gaaauugugc caacaaagag gauacaugga aguuccucga caugaugcag      480

auauacgaug gcaagaaaua uuacaucuau ggugagccaa gaaaguuaau uacucaagac      540

uuuguucggc ugaccuaccu ugaauaccac caggugcccu gcuccuaucc ugcacauuac      600

caguucuugu gggggccacg cgccuauaca gagaccucua aaaugaaggu ccuggaauac      660

cuagcuaaag ugaaugauau cgcacccgga gccuuuagcu cccaguauga ggaagcucuc      720

caagacgagg aggaaucacc uagucagaga uguagcagga acuggcacua cugcucuggc      780

caggauuguc ugcgggccaa guucuccuca uuuagccagc cauauuga                   828


<210>  2335
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2335
augaccagcg ccggcguguu caacgccggc agcgacgaga gagccaacag cagagacgag       60

gaguaccccu gcagcagcga ggugagcccc agcaccgaga gcagcugcag caacuucauc      120

aacaucaagg ugggccugcu ggagcaguuc cugcuguaca aguucaagau gaagcagaga      180

auccugaagg aggacaugcu gaagaucgug aaccccagau accagaacca guucgccgag      240

auccacagaa gagccagcga gcacaucgag gugguguucg ccguggaccu gaaggaggug      300

aaccccaccu gccaccugua cgaccuggug agcaagcuga agcugcccaa caacggcaga      360

auccacgugg gcaaggugcu gcccaagacc ggccugcuga ugaccuuccu gguggugauc      420

uuccugaagg gcaacugcgc caacaaggag gacaccugga aguuccugga caugaugcag      480

aucuacgacg gcaagaagua cuacaucuac ggcgagccca gaaagcugau cacccaggac      540

uucgugagac ugaccuaccu ggaguaccac caggugcccu gcagcuaccc cgcccacuac      600

caguuccugu ggggccccag agccuacacc gagaccagca agaugaaggu gcuggaguac      660

cuggccaagg ugaacgacau cgcccccggc gccuucagca gccaguacga ggaggcccug      720

caggacgagg aggagagccc cagccagaga ugcagcagaa acuggcacua cugcagcggc      780

caggacugcc ugagagccaa guucagcagc uucagccagc ccuacuga                   828


<210>  2336
<211>  828
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B5__Homo_sapiens__CCDS65233.1

<400>  2336
augaccagcg ccggcguguu caacgcuggg uccgacgaga gagccaauuc ucgggaugaa       60

gaguaccccu gcagcuccga agucucuccu agcacagagu ccucuuguag caacuuuauc      120

aauauuaagg uuggacugcu cgaacaguuc cugcuuuaua aauuuaagau gaaacaacgc      180

auccugaagg aggacaugcu caaaauugug aacccgagau accagaauca guucgcggag      240

auccaccggc gcgcuuccga acauauugag guggucuuug ccguggaucu gaaggaaguu      300

aaccccacgu gccaccuuua ugaccuggug agcaagcuca aacugccuaa uaacggcaga      360

auccaugucg ggaaggugcu gcccaaaacc ggacuccuga ugacauuccu uguugugauc      420

uuucugaagg gcaauugugc caacaaagag gauaccugga aguuccucga caugaugcag      480

auuuacgaug ggaagaaaua uuacaucuau ggagagccuc ggaagcugau uacacaagac      540

uuuguccgcc uuaccuaccu ggaauaccac caggugcccu gcucuuaucc ugcucauuac      600

caguuccucu ggggcccgag agccuauaca gagaccucca aaaugaaggu gcuggaauac      660

cuggcuaaag ucaaugauau cgcccccggc gcguuuagcu cucaguauga ggaagcccuc      720

caagacgagg aggaaucccc uagccagcgg uguucucgca acuggcacua cugcuccggg      780

caggauuguc ugagagcuaa guucagcucc uuuucucagc ccuauuga                   828


<210>  2337
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-B6__Homo_sapiens__Q8N7X4

<400>  2337

Met Pro Arg Gly His Lys Ser Lys Leu Arg Thr Cys Glu Lys Arg Gln 
1               5                   10                  15      


Glu Thr Asn Gly Gln Pro Gln Gly Leu Thr Gly Pro Gln Ala Thr Ala 
            20                  25                  30          


Glu Lys Gln Glu Glu Ser His Ser Ser Ser Ser Ser Ser Arg Ala Cys 
        35                  40                  45              


Leu Gly Asp Cys Arg Arg Ser Ser Asp Ala Ser Ile Pro Gln Glu Ser 
    50                  55                  60                  


Gln Gly Val Ser Pro Thr Gly Ser Pro Asp Ala Val Val Ser Tyr Ser 
65                  70                  75                  80  


Lys Ser Asp Val Ala Ala Asn Gly Gln Asp Glu Lys Ser Pro Ser Thr 
                85                  90                  95      


Ser Arg Asp Ala Ser Val Pro Gln Glu Ser Gln Gly Ala Ser Pro Thr 
            100                 105                 110         


Gly Ser Pro Asp Ala Gly Val Ser Gly Ser Lys Tyr Asp Val Ala Ala 
        115                 120                 125             


Asn Gly Gln Asp Glu Lys Ser Pro Ser Thr Ser His Asp Val Ser Val 
    130                 135                 140                 


Pro Gln Glu Ser Gln Gly Ala Ser Pro Thr Gly Ser Pro Asp Ala Gly 
145                 150                 155                 160 


Val Ser Gly Ser Lys Tyr Asp Val Ala Ala Glu Gly Glu Asp Glu Glu 
                165                 170                 175     


Ser Val Ser Ala Ser Gln Lys Ala Ile Ile Phe Lys Arg Leu Ser Lys 
            180                 185                 190         


Asp Ala Val Lys Lys Lys Ala Cys Thr Leu Ala Gln Phe Leu Gln Lys 
        195                 200                 205             


Lys Phe Glu Lys Lys Glu Ser Ile Leu Lys Ala Asp Met Leu Lys Cys 
    210                 215                 220                 


Val Arg Arg Glu Tyr Lys Pro Tyr Phe Pro Gln Ile Leu Asn Arg Thr 
225                 230                 235                 240 


Ser Gln His Leu Val Val Ala Phe Gly Val Glu Leu Lys Glu Met Asp 
                245                 250                 255     


Ser Ser Gly Glu Ser Tyr Thr Leu Val Ser Lys Leu Gly Leu Pro Ser 
            260                 265                 270         


Glu Gly Ile Leu Ser Gly Asp Asn Ala Leu Pro Lys Ser Gly Leu Leu 
        275                 280                 285             


Met Ser Leu Leu Val Val Ile Phe Met Asn Gly Asn Cys Ala Thr Glu 
    290                 295                 300                 


Glu Glu Val Trp Glu Phe Leu Gly Leu Leu Gly Ile Tyr Asp Gly Ile 
305                 310                 315                 320 


Leu His Ser Ile Tyr Gly Asp Ala Arg Lys Ile Ile Thr Glu Asp Leu 
                325                 330                 335     


Val Gln Asp Lys Tyr Val Val Tyr Arg Gln Val Cys Asn Ser Asp Pro 
            340                 345                 350         


Pro Cys Tyr Glu Phe Leu Trp Gly Pro Arg Ala Tyr Ala Glu Thr Thr 
        355                 360                 365             


Lys Met Arg Val Leu Arg Val Leu Ala Asp Ser Ser Asn Thr Ser Pro 
    370                 375                 380                 


Gly Leu Tyr Pro His Leu Tyr Glu Asp Ala Leu Ile Asp Glu Val Glu 
385                 390                 395                 400 


Arg Ala Leu Arg Leu Arg Ala 
                405         


<210>  2338
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-B6__Homo_sapiens__AAH67286

<400>  2338
augccucggg gucacaagag uaagcuccgu accugugaga aacgccaaga gaccaauggu       60

cagccacagg gucucacggg uccccaggcc acugcagaga agcaggaaga gucccacucu      120

uccucauccu cuucucgcgc uugucugggu gauugucgua ggucuucuga ugccuccauu      180

ccucaggagu cucagggagu gucacccacu gggucuccug augcaguugu uucauauuca      240

aaauccgaug uggcugccaa cggccaagau gagaaaaguc caagcaccuc ccgugaugcc      300

uccguuccuc aggagucuca gggagcuuca cccacuggcu cuccugaugc agguguuuca      360

ggcucaaaau augauguggc ugccaacggc caagaugaga aaaguccaag cacuucccau      420

gaugucuccg uuccucagga gucucaggga gcuucaccca cuggcucgcc ugaugcaggu      480

guuucaggcu caaaauauga uguggcugcc gagggugaag augaggaaag uguaagcgcc      540

ucacagaaag ccaucauuuu uaagcgcuua agcaaagaug cuguaaagaa gaaggcgugc      600

acguuggcgc aauuccugca gaagaaguuu gagaagaaag aguccauuuu gaaggcagac      660

augcugaagu guguccgcag agaguacaag cccuacuucc cucagauccu caacagaacc      720

ucccaacauu uggugguggc cuuuggcguu gaauugaaag aaauggauuc cagcggcgag      780

uccuacaccc uugucagcaa gcuaggccuc cccagugaag gaauucugag uggugauaau      840

gcgcugccga agucgggucu ccugaugucg cuccugguug ugaucuucau gaacggcaac      900

ugugccacug aagaggaggu cugggaguuc cugggucugu uggggauaua ugaugggauc      960

cugcauucaa ucuaugggga ugcucggaag aucauuacug aagauuuggu gcaagauaag     1020

uacgugguuu accggcaggu gugcaacagu gauccuccau gcuaugaguu ccuguggggu     1080

ccacgagccu augcugaaac caccaagaug agaguccugc guguuuuggc cgacagcagu     1140

aacaccaguc ccgguuuaua cccacaucug uaugaagacg cuuugauaga ugagguagag     1200

agagcauuga gacugagagc uuaa                                            1224


<210>  2339
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-B6__Homo_sapiens__AAH67286

<400>  2339
augccccgcg gccacaagag caagcugcgg accugcgaga agcgccagga gaccaacggg       60

cagccgcagg gccucacggg gccccaggcc accgccgaga agcaggagga gucccacagc      120

uccagcucca gcucccgggc gugccugggc gacugccgcc ggagcuccga cgccagcauc      180

ccccaggagu cccagggggu gagccccacc ggcuccccgg acgccgucgu gagcuacucc      240

aagagcgacg uggccgccaa cggccaggac gagaaguccc ccagcaccuc ccgcgacgcg      300

agcguccccc aggagagcca gggggccucc cccacgggca gcccggacgc cggggugucc      360

ggcagcaagu acgacguggc cgcgaacggg caggacgaga agucccccag caccucccac      420

gacgucagcg ugccccagga gucccagggc gccagcccca ccggcucccc ggacgccggg      480

gugagcggcu ccaaguacga cgucgccgcc gagggggagg acgaggagag cguguccgcg      540

agccagaagg ccaucaucuu caagcggcug uccaaggacg ccgugaagaa gaaggccugc      600

acccucgccc aguuccugca gaagaaguuc gagaagaagg agagcauccu gaaggcggac      660

augcucaagu gcguccgccg ggaguacaag cccuacuucc cccagauccu gaaccgcacg      720

ucccagcacc uggugguggc cuucggcguc gagcucaagg agauggacag cagcggcgag      780

uccuacaccc uggugagcaa gcuggggcuc cccuccgagg gcauccugag cggggacaac      840

gcccugccga aguccggccu ccugaugagc cugcucgugg ucaucuucau gaacgggaac      900

ugcgccaccg aggaggaggu gugggaguuc cugggccugc ucggcaucua cgacgggauc      960

cugcacucca ucuacggcga cgcccggaag aucaucaccg aggaccuggu gcaggacaag     1020

uacgucgugu accgccaggu gugcaacagc gacccgcccu gcuacgaguu ccucuggggg     1080

ccccgggcgu acgccgagac gaccaagaug cgcguccugc gggugcuggc cgacuccagc     1140

aacaccuccc ccggccucua cccccaccug uacgaggacg cccugaucga cgaggucgag     1200

cgcgcccucc ggcugcgcgc guga                                            1224


<210>  2340
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-B6__Homo_sapiens__AAH67286

<400>  2340
augccccgcg gccacaaguc caagcuccgc accugcgaga agcgccagga gaccaacggc       60

cagccccagg gccucaccgg cccccaggcc accgccgaga agcaggagga gucccacucc      120

uccuccuccu ccucccgcgc cugccucggc gacugccgcc gcuccuccga cgccuccauc      180

ccccaggagu cccagggcgu cucccccacc ggcucccccg acgccgucgu cuccuacucc      240

aaguccgacg ucgccgccaa cggccaggac gagaaguccc ccuccaccuc ccgcgacgcc      300

uccguccccc aggaguccca gggcgccucc cccaccggcu cccccgacgc cggcgucucc      360

ggcuccaagu acgacgucgc cgccaacggc caggacgaga agucccccuc caccucccac      420

gacgucuccg ucccccagga gucccagggc gccuccccca ccggcucccc cgacgccggc      480

gucuccggcu ccaaguacga cgucgccgcc gagggcgagg acgaggaguc cgucuccgcc      540

ucccagaagg ccaucaucuu caagcgccuc uccaaggacg ccgucaagaa gaaggccugc      600

acccucgccc aguuccucca gaagaaguuc gagaagaagg aguccauccu caaggccgac      660

augcucaagu gcguccgccg cgaguacaag cccuacuucc cccagauccu caaccgcacc      720

ucccagcacc ucgucgucgc cuucggcguc gagcucaagg agauggacuc cuccggcgag      780

uccuacaccc ucgucuccaa gcucggccuc cccuccgagg gcauccucuc cggcgacaac      840

gcccucccca aguccggccu ccucaugucc cuccucgucg ucaucuucau gaacggcaac      900

ugcgccaccg aggaggaggu cugggaguuc cucggccucc ucggcaucua cgacggcauc      960

cuccacucca ucuacggcga cgcccgcaag aucaucaccg aggaccucgu ccaggacaag     1020

uacgucgucu accgccaggu cugcaacucc gacccccccu gcuacgaguu ccucuggggc     1080

ccccgcgccu acgccgagac caccaagaug cgcguccucc gcguccucgc cgacuccucc     1140

aacaccuccc ccggccucua cccccaccuc uacgaggacg cccucaucga cgaggucgag     1200

cgcgcccucc gccuccgcgc cuga                                            1224


<210>  2341
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-B6__Homo_sapiens__AAH67286

<400>  2341
augcccagag gccacaagag caaacugagg accugcgaga agcggcagga aacaaacggg       60

caaccucagg gacucacugg uccacaggcc acggcugaga aacaggaaga gucccauucu      120

ucaaguagcu ccucucgcgc augucuuggc gacugccgac guucgucaga ugccagcauc      180

ccgcaagaaa gucagggggu gucccccacc ggaucuccug acgcggucgu uagcuacucc      240

aagucagaug uggcugccaa uggccaggac gagaaaaguc caagcacauc uagagaugca      300

uccguacccc aggagucaca aggugccagc ccuacuggga guccagacgc uggagugucu      360

ggcuccaagu augaugucgc agccaacggc caggacgaaa agagccccuc gaccucucac      420

gauguguccg uuccucagga gucacagggg gcuaguccaa caggaagccc ggacgccggu      480

guguccggcu cuaaauacga ugucgcggca gaaggggagg acgaggaaag cgugucagcc      540

agucaaaagg cuauuauauu caaaaggcug uccaaggaug ccgugaaaaa gaaggcaugu      600

accuuggcuc aguuuuuaca gaaaaaguuc gagaaaaagg aaagcauccu gaaagccgac      660

augcuaaagu gcguucggcg cgaguauaaa cccuacuuuc cucaaauucu caauagaacu      720

ucucagcauc ugguggucgc guucggagug gaacuuaagg agauggacuc aaguggcgag      780

agcuauacac ugguguccaa guugggucuc ccaucugaag ggauccuguc gggagauaac      840

gcccugccca aaagcggccu cuuaaugucc cugcuugucg uuauuuuuau gaauggcaac      900

ugugcaaccg aggaagaggu gugggaguuc uuggggcugc uaggaaucua cgacgguaua      960

cuccacucaa ucuauggcga ugcuaggaag auuaucacgg aagaccuggu acaggauaaa     1020

uacguggucu accggcaggu augcaauagu gacccuccau guuaugaguu ucuuuggggg     1080

ccccgcgccu acgcugaaac uaccaagaug cgaguucuga gaguguuggc cgauucuagc     1140

aacacauccc cgggacucua uccucaucug uacgaggacg cauuaauuga ugaagucgag     1200

agggcccugc ggcuccgugc uuga                                            1224


<210>  2342
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-B6__Homo_sapiens__AAH67286

<400>  2342
augcccagag gccacaagag caagcugaga accugcgaga agagacagga gaccaacggc       60

cagccccagg gccugaccgg cccccaggcc accgccgaga agcaggagga gagccacagc      120

agcagcagca gcagcagagc cugccugggc gacugcagaa gaagcagcga cgccagcauc      180

ccccaggaga gccagggcgu gagccccacc ggcagccccg acgccguggu gagcuacagc      240

aagagcgacg uggccgccaa cggccaggac gagaagagcc ccagcaccag cagagacgcc      300

agcgugcccc aggagagcca gggcgccagc cccaccggca gccccgacgc cggcgugagc      360

ggcagcaagu acgacguggc cgccaacggc caggacgaga agagccccag caccagccac      420

gacgugagcg ugccccagga gagccagggc gccagcccca ccggcagccc cgacgccggc      480

gugagcggca gcaaguacga cguggccgcc gagggcgagg acgaggagag cgugagcgcc      540

agccagaagg ccaucaucuu caagagacug agcaaggacg ccgugaagaa gaaggccugc      600

acccuggccc aguuccugca gaagaaguuc gagaagaagg agagcauccu gaaggccgac      660

augcugaagu gcgugagaag agaguacaag cccuacuucc cccagauccu gaacagaacc      720

agccagcacc uggugguggc cuucggcgug gagcugaagg agauggacag cagcggcgag      780

agcuacaccc uggugagcaa gcugggccug cccagcgagg gcauccugag cggcgacaac      840

gcccugccca agagcggccu gcugaugagc cugcuggugg ugaucuucau gaacggcaac      900

ugcgccaccg aggaggaggu gugggaguuc cugggccugc ugggcaucua cgacggcauc      960

cugcacagca ucuacggcga cgccagaaag aucaucaccg aggaccuggu gcaggacaag     1020

uacguggugu acagacaggu gugcaacagc gacccccccu gcuacgaguu ccuguggggc     1080

cccagagccu acgccgagac caccaagaug agagugcuga gagugcuggc cgacagcagc     1140

aacaccagcc ccggccugua cccccaccug uacgaggacg cccugaucga cgagguggag     1200

agagcccuga gacugagagc cuga                                            1224


<210>  2343
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-B6__Homo_sapiens__AAH67286

<400>  2343
augcccagag gccacaagag caaacugcgg accugcgaga agcgccagga aacaaacggg       60

caaccucagg gacucacggg cccgcaggcc accgcugaga aacaggaaga gucccauucu      120

agcuccucua gcuccagagc cugucugggg gacugccggc gcucuagcga ugcguccauc      180

ccccaagaaa gccagggagu gucuccuaca ggcucccccg acgcugucgu uagcuacucu      240

aaguccgaug uggccgccaa ugggcaggac gagaaaagcc cuucuaccuc cagagaugcu      300

agcgugcccc aggaguccca aggagccucu ccuacaggca gcccggacgc uggcgucucc      360

gggagcaagu augauguggc cgcgaacgga caggacgaaa agucucccuc caccagccac      420

gauguuucug ugccucagga gagccagggc gccuccccca cagggucucc ugacgcugga      480

gucagcggcu ccaaauacga uguggccgcu gaaggggagg acgaggaaag cguuucugcc      540

ucccaaaagg cgauuaucuu caaacggcuu agcaaggaug ccgugaaaaa gaaggcuugu      600

acccuggccc aguuucucca gaaaaaguuc gagaaaaagg aaucuauucu gaaagcugac      660

augcuuaagu gcguccgcag agaguauaaa cccuacuuuc cgcaaauccu gaaucggacg      720

ucccagcauc ucgugguggc cuucggaguc gaacugaagg agauggacag cuccggcgag      780

ucuuauaccc ugguuagcaa gcucggccug ccuuccgaag ggauucuuuc uggagauaac      840

gcccugccca aaagcggccu ccugaugucc cuucuggugg ugaucuuuau gaaugggaac      900

ugugcuacag aggaagaggu cugggaguuc cucggacugc ugggcaucua cgacgggauu      960

cuccacagca ucuauggaga ugcgcgcaag auuaucaccg aagaccuggu gcaggauaaa     1020

uacguugugu acagacaggu cugcaauucu gacccucccu guuaugaguu ucuuuggggc     1080

ccccgggccu acgcugaaac aaccaagaug cgcgugcuga gaguucucgc cgauuccagc     1140

aacacgucuc cuggccugua uccgcaucuu uacgaggacg cccugauuga ugaaguggag     1200

cgggcucucc gccugagagc cuga                                            1224


<210>  2344
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-C1__Homo_sapiens__O60732

<400>  2344

Met Gly Asp Lys Asp Met Pro Thr Ala Gly Met Pro Ser Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ser Glu Ser Pro Gln Ser Cys Pro Glu Gly Glu Asp Ser Gln 
            20                  25                  30          


Ser Pro Leu Gln Ile Pro Gln Ser Ser Pro Glu Ser Asp Asp Thr Leu 
        35                  40                  45              


Tyr Pro Leu Gln Ser Pro Gln Ser Arg Ser Glu Gly Glu Asp Ser Ser 
    50                  55                  60                  


Asp Pro Leu Gln Arg Pro Pro Glu Gly Lys Asp Ser Gln Ser Pro Leu 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Ser Pro Glu Gly Asp Asp Thr Gln Ser Pro Leu 
                85                  90                  95      


Gln Asn Ser Gln Ser Ser Pro Glu Gly Lys Asp Ser Leu Ser Pro Leu 
            100                 105                 110         


Glu Ile Ser Gln Ser Pro Pro Glu Gly Glu Asp Val Gln Ser Pro Leu 
        115                 120                 125             


Gln Asn Pro Ala Ser Ser Phe Phe Ser Ser Ala Leu Leu Ser Ile Phe 
    130                 135                 140                 


Gln Ser Ser Pro Glu Ser Thr Gln Ser Pro Phe Glu Gly Phe Pro Gln 
145                 150                 155                 160 


Ser Val Leu Gln Ile Pro Val Ser Ala Ala Ser Ser Ser Thr Leu Val 
                165                 170                 175     


Ser Ile Phe Gln Ser Ser Pro Glu Ser Thr Gln Ser Pro Phe Glu Gly 
            180                 185                 190         


Phe Pro Gln Ser Pro Leu Gln Ile Pro Val Ser Arg Ser Phe Ser Ser 
        195                 200                 205             


Thr Leu Leu Ser Ile Phe Gln Ser Ser Pro Glu Arg Thr Gln Ser Thr 
    210                 215                 220                 


Phe Glu Gly Phe Ala Gln Ser Pro Leu Gln Ile Pro Val Ser Pro Ser 
225                 230                 235                 240 


Ser Ser Ser Thr Leu Leu Ser Leu Phe Gln Ser Phe Ser Glu Arg Thr 
                245                 250                 255     


Gln Ser Thr Phe Glu Gly Phe Ala Gln Ser Ser Leu Gln Ile Pro Val 
            260                 265                 270         


Ser Pro Ser Phe Ser Ser Thr Leu Val Ser Leu Phe Gln Ser Ser Pro 
        275                 280                 285             


Glu Arg Thr Gln Ser Thr Phe Glu Gly Phe Pro Gln Ser Pro Leu Gln 
    290                 295                 300                 


Ile Pro Val Ser Ser Ser Ser Ser Ser Thr Leu Leu Ser Leu Phe Gln 
305                 310                 315                 320 


Ser Ser Pro Glu Arg Thr His Ser Thr Phe Glu Gly Phe Pro Gln Ser 
                325                 330                 335     


Leu Leu Gln Ile Pro Met Thr Ser Ser Phe Ser Ser Thr Leu Leu Ser 
            340                 345                 350         


Ile Phe Gln Ser Ser Pro Glu Ser Ala Gln Ser Thr Phe Glu Gly Phe 
        355                 360                 365             


Pro Gln Ser Pro Leu Gln Ile Pro Gly Ser Pro Ser Phe Ser Ser Thr 
    370                 375                 380                 


Leu Leu Ser Leu Phe Gln Ser Ser Pro Glu Arg Thr His Ser Thr Phe 
385                 390                 395                 400 


Glu Gly Phe Pro Gln Ser Pro Leu Gln Ile Pro Met Thr Ser Ser Phe 
                405                 410                 415     


Ser Ser Thr Leu Leu Ser Ile Leu Gln Ser Ser Pro Glu Ser Ala Gln 
            420                 425                 430         


Ser Ala Phe Glu Gly Phe Pro Gln Ser Pro Leu Gln Ile Pro Val Ser 
        435                 440                 445             


Ser Ser Phe Ser Tyr Thr Leu Leu Ser Leu Phe Gln Ser Ser Pro Glu 
    450                 455                 460                 


Arg Thr His Ser Thr Phe Glu Gly Phe Pro Gln Ser Pro Leu Gln Ile 
465                 470                 475                 480 


Pro Val Ser Ser Ser Ser Ser Ser Ser Thr Leu Leu Ser Leu Phe Gln 
                485                 490                 495     


Ser Ser Pro Glu Cys Thr Gln Ser Thr Phe Glu Gly Phe Pro Gln Ser 
            500                 505                 510         


Pro Leu Gln Ile Pro Gln Ser Pro Pro Glu Gly Glu Asn Thr His Ser 
        515                 520                 525             


Pro Leu Gln Ile Val Pro Ser Leu Pro Glu Trp Glu Asp Ser Leu Ser 
    530                 535                 540                 


Pro His Tyr Phe Pro Gln Ser Pro Pro Gln Gly Glu Asp Ser Leu Ser 
545                 550                 555                 560 


Pro His Tyr Phe Pro Gln Ser Pro Pro Gln Gly Glu Asp Ser Leu Ser 
                565                 570                 575     


Pro His Tyr Phe Pro Gln Ser Pro Gln Gly Glu Asp Ser Leu Ser Pro 
            580                 585                 590         


His Tyr Phe Pro Gln Ser Pro Pro Gln Gly Glu Asp Ser Met Ser Pro 
        595                 600                 605             


Leu Tyr Phe Pro Gln Ser Pro Leu Gln Gly Glu Glu Phe Gln Ser Ser 
    610                 615                 620                 


Leu Gln Ser Pro Val Ser Ile Cys Ser Ser Ser Thr Pro Ser Ser Leu 
625                 630                 635                 640 


Pro Gln Ser Phe Pro Glu Ser Ser Gln Ser Pro Pro Glu Gly Pro Val 
                645                 650                 655     


Gln Ser Pro Leu His Ser Pro Gln Ser Pro Pro Glu Gly Met His Ser 
            660                 665                 670         


Gln Ser Pro Leu Gln Ser Pro Glu Ser Ala Pro Glu Gly Glu Asp Ser 
        675                 680                 685             


Leu Ser Pro Leu Gln Ile Pro Gln Ser Pro Leu Glu Gly Glu Asp Ser 
    690                 695                 700                 


Leu Ser Ser Leu His Phe Pro Gln Ser Pro Pro Glu Trp Glu Asp Ser 
705                 710                 715                 720 


Leu Ser Pro Leu His Phe Pro Gln Phe Pro Pro Gln Gly Glu Asp Phe 
                725                 730                 735     


Gln Ser Ser Leu Gln Ser Pro Val Ser Ile Cys Ser Ser Ser Thr Ser 
            740                 745                 750         


Leu Ser Leu Pro Gln Ser Phe Pro Glu Ser Pro Gln Ser Pro Pro Glu 
        755                 760                 765             


Gly Pro Ala Gln Ser Pro Leu Gln Arg Pro Val Ser Ser Phe Phe Ser 
    770                 775                 780                 


Tyr Thr Leu Ala Ser Leu Leu Gln Ser Ser His Glu Ser Pro Gln Ser 
785                 790                 795                 800 


Pro Pro Glu Gly Pro Ala Gln Ser Pro Leu Gln Ser Pro Val Ser Ser 
                805                 810                 815     


Phe Pro Ser Ser Thr Ser Ser Ser Leu Ser Gln Ser Ser Pro Val Ser 
            820                 825                 830         


Ser Phe Pro Ser Ser Thr Ser Ser Ser Leu Ser Lys Ser Ser Pro Glu 
        835                 840                 845             


Ser Pro Leu Gln Ser Pro Val Ile Ser Phe Ser Ser Ser Thr Ser Leu 
    850                 855                 860                 


Ser Pro Phe Ser Glu Glu Ser Ser Ser Pro Val Asp Glu Tyr Thr Ser 
865                 870                 875                 880 


Ser Ser Asp Thr Leu Leu Glu Ser Asp Ser Leu Thr Asp Ser Glu Ser 
                885                 890                 895     


Leu Ile Glu Ser Glu Pro Leu Phe Thr Tyr Thr Leu Asp Glu Lys Val 
            900                 905                 910         


Asp Glu Leu Ala Arg Phe Leu Leu Leu Lys Tyr Gln Val Lys Gln Pro 
        915                 920                 925             


Ile Thr Lys Ala Glu Met Leu Thr Asn Val Ile Ser Arg Tyr Thr Gly 
    930                 935                 940                 


Tyr Phe Pro Val Ile Phe Arg Lys Ala Arg Glu Phe Ile Glu Ile Leu 
945                 950                 955                 960 


Phe Gly Ile Ser Leu Arg Glu Val Asp Pro Asp Asp Ser Tyr Val Phe 
                965                 970                 975     


Val Asn Thr Leu Asp Leu Thr Ser Glu Gly Cys Leu Ser Asp Glu Gln 
            980                 985                 990         


Gly Met Ser Gln Asn Arg Leu Leu Ile Leu Ile Leu Ser Ile Ile Phe 
        995                 1000                1005            


Ile Lys Gly Thr Tyr Ala Ser Glu Glu Val Ile Trp Asp Val Leu Ser 
    1010                1015                1020                


Gly Ile Gly Val Arg Ala Gly Arg Glu His Phe Ala Phe Gly Glu Pro 
1025                1030                1035                1040


Arg Glu Leu Leu Thr Lys Val Trp Val Gln Glu His Tyr Leu Glu Tyr 
                1045                1050                1055    


Arg Glu Val Pro Asn Ser Ser Pro Pro Arg Tyr Glu Phe Leu Trp Gly 
            1060                1065                1070        


Pro Arg Ala His Ser Glu Val Ile Lys Arg Lys Val Val Glu Phe Leu 
        1075                1080                1085            


Ala Met Leu Lys Asn Thr Val Pro Ile Thr Phe Pro Ser Ser Tyr Lys 
    1090                1095                1100                


Asp Ala Leu Lys Asp Val Glu Glu Arg Ala Gln Ala Ile Ile Asp Thr 
1105                1110                1115                1120


Thr Asp Asp Ser Thr Ala Thr Glu Ser Ala Ser Ser Ser Val Met Ser 
                1125                1130                1135    


Pro Ser Phe Ser Ser Glu 
            1140        


<210>  2345
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2345
augggggaca aggauaugcc uacugcuggg augccgaguc uucuccagag uuccucugag       60

aguccucaga guuguccuga gggggaggac ucccagucuc cucuccagau uccccagagu      120

ucuccugaga gcgacgacac ccuguauccu cuccagaguc cucagagucg uucugagggg      180

gaggacuccu cggauccucu ccagagaccu ccugagggga aggacuccca gucuccucuc      240

cagauucccc agaguucucc ugagggcgac gacacccagu cuccucucca gaauucucag      300

aguucuccug aggggaagga cucccugucu ccucuagaga uuucucagag cccuccugag      360

ggugaggaug uccagucucc ucugcagaau ccugcgaguu ccuucuucuc cucugcuuua      420

uugaguauuu uccagaguuc cccugagagu acucaaaguc cuuuugaggg uuuuccccag      480

ucuguucucc agauuccugu gagcgccgcc uccuccucca cuuuagugag uauuuuccag      540

aguuccccug agaguacuca aaguccuuuu gaggguuuuc cccagucucc acuccagauu      600

ccugugagcc gcuccuucuc cuccacuuua uugaguauuu uccagaguuc cccugagaga      660

acucagagua cuuuugaggg uuuugcccag ucuccucucc agauuccugu gagccccucc      720

uccuccucca cuuuacugag ucuuuuccag aguuucucug agagaacuca gaguacuuuu      780

gaggguuuug cccagucuuc ucuccagauu ccugugagcc ccuccuucuc cuccacuuua      840

gugagucuuu uccagaguuc cccugagaga acucagagua cuuuugaggg uuuuccccag      900

ucuccucucc agauuccugu gagcuccucc uccuccucca cuuuauugag ucuuuuccag      960

aguuccccug agagaacuca caguacuuuu gaggguuuuc cccagucucu ucuccagauu     1020

ccuaugaccu ccuccuucuc cucuacuuua uugaguauuu uccagaguuc uccugagagu     1080

gcucaaagua cuuuugaggg uuuuccccag ucuccucucc agauuccugg gagccccucc     1140

uucuccucca cuuuacugag ucuuuuccag aguuccccug agagaacuca caguacuuuu     1200

gaggguuuuc cccagucucc ucuccagauu ccuaugaccu ccuccuucuc cucuacuuua     1260

uugaguauuu uacagaguuc uccugagagu gcucaaagug cuuuugaggg uuuuccccag     1320

ucuccucucc agauuccugu gagcuccucu uucuccuaca cuuuauugag ucuuuuccag     1380

aguuccccug agagaacuca caguacuuuu gaggguuuuc cccagucucc ucuccagauu     1440

ccugugagcu ccuccuccuc cuccuccacu uuauugaguc uuuuccagag uuccccugag     1500

uguacucaaa guacuuuuga ggguuuuccc cagucuccuc uccagauucc ucagaguccu     1560

ccugaagggg agaauaccca uucuccucuc cagauuguuc caagucuucc ugagugggag     1620

gacucccugu cuccucacua cuuuccucag agcccuccuc agggggagga cucccuaucu     1680

ccucacuacu uuccucagag cccuccucag ggggaggacu cccugucucc ucacuacuuu     1740

ccucagagcc cucaggggga ggacucccug ucuccucacu acuuuccuca gagcccuccu     1800

cagggggagg acuccauguc uccucucuac uuuccucaga guccucuuca gggggaggaa     1860

uuccagucuu cucuccagag cccugugagc aucugcuccu ccuccacucc auccagucuu     1920

ccccagaguu ucccugagag uucucagagu ccuccugagg ggccugucca gucuccucuc     1980

cauaguccuc agagcccucc ugaggggaug cacucccaau cuccucucca gaguccugag     2040

agugcuccug agggggagga uucccugucu ccucuccaaa uuccucagag uccucuugag     2100

ggagaggacu cccugucuuc ucuccauuuu ccucagaguc cuccugagug ggaggacucc     2160

cucucuccuc uccacuuucc ucaguuuccu ccucaggggg aggacuucca gucuucucuc     2220

cagaguccug ugaguaucug cuccuccucc acuucuuuga gucuucccca gaguuucccu     2280

gagaguccuc agaguccucc ugaggggccu gcucagucuc cucuccagag accugucagc     2340

uccuucuucu ccuacacuuu agcgagucuu cuccaaaguu cccaugagag uccucagagu     2400

ccuccugagg ggccugccca gucuccucuc cagaguccug ugagcuccuu ccccuccucc     2460

acuucaucga gucuuuccca gaguucuccu gugagcuccu uccccuccuc cacuucaucg     2520

agucuuucca agaguucccc ugagaguccu cuccagaguc cugugaucuc cuucuccucc     2580

uccacuucau ugagcccauu cagugaagag uccagcagcc caguagauga auauacaagu     2640

uccucagaca ccuugcuaga gagugauucc uugacagaca gcgaguccuu gauagagagc     2700

gagcccuugu ucacuuauac acuggaugaa aagguggacg aguuggcgcg guuucuucuc     2760

cucaaauauc aagugaagca gccuaucaca aaggcagaga ugcugacgaa ugucaucagc     2820

agguacacgg gcuacuuucc ugugaucuuc aggaaagccc gugaguucau agagauacuu     2880

uuuggcauuu cccugagaga aguggacccu gaugacuccu augucuuugu aaacacauua     2940

gaccucaccu cugaggggug ucugagugau gagcagggca ugucccagaa ccgccuccug     3000

auucuuauuc ugaguaucau cuucauaaag ggcaccuaug ccucugagga ggucaucugg     3060

gaugugcuga guggaauagg ggugcgugcu gggagggagc acuuugccuu uggggagccc     3120

agggagcucc ucacuaaagu uugggugcag gaacauuacc uagaguaccg ggaggugccc     3180

aacucuucuc cuccucguua cgaauuccug ugggguccaa gagcucauuc agaagucauu     3240

aagaggaaag uaguagaguu uuuggccaug cuaaagaaua ccgucccuau uaccuuucca     3300

uccucuuaca aggaugcuuu gaaagaugug gaagagagag cccaggccau aauugacacc     3360

acagaugauu cgacugccac agaaagugca agcuccagug ucaugucccc cagcuucucu     3420

ucugaguga                                                             3429


<210>  2346
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2346
augggcgaca aggacaugcc caccgccggg augccgagcc ugcuccaguc cagcuccgag       60

agcccccagu ccugccccga gggcgaggac agccagagcc cccugcagau cccgcagagc      120

ucccccgaga gcgacgacac ccuguacccc cuccagagcc cccagucccg cuccgagggg      180

gaggacagcu ccgacccgcu gcagcggccg cccgagggca aggacagcca gagcccccug      240

cagauccccc aguccucccc cgagggggac gacacgcaga gcccccucca gaacagccag      300

uccagccccg agggcaagga cucccugagc ccgcuggaga ucucccagag cccgcccgag      360

ggcgaggacg ugcagagccc ccuccagaac cccgccuccu ccuucuucag cuccgcgcug      420

cugagcaucu uccaguccag ccccgagucc acccagagcc ccuucgaggg guucccccag      480

uccguccucc agaucccggu gagcgccgcc uccagcagca cccugguguc caucuuccag      540

agcucccccg agagcaccca gucccccuuc gagggcuucc cccagagccc gcugcagauc      600

cccgucuccc gcagcuucuc cagcacgcuc cuguccaucu uccagagcuc ccccgagcgg      660

acccagagca ccuucgaggg guucgcccag uccccgcugc agauccccgu gagccccucc      720

agcagcucca cccuccugag ccuguuccag uccuucagcg agcgcacgca guccaccuuc      780

gagggcuucg cccagagcuc ccuccagauc cccgugagcc cguccuucag cuccacccug      840

gucagccugu uccaguccag ccccgagcgg acccagucca cguucgaggg guucccccag      900

agcccccucc agaucccggu guccagcucc agcagcucca cccugcugag ccucuuccag      960

uccagccccg agcgcaccca cuccaccuuc gagggcuucc cccagagccu gcugcagauc     1020

cccaugacgu ccagcuucuc cagcacccuc cuguccaucu uccagagcuc cccggagagc     1080

gcgcagucca ccuucgaggg cuucccccag agcccccugc agauccccgg guccccgagc     1140

uucuccagca cccuccugag ccuguuccag uccagccccg agcggacgca cuccaccuuc     1200

gagggcuucc cccagagccc ccuccagauc ccgaugaccu ccagcuucuc cagcacccug     1260

cuguccaucc uccagagcuc ccccgagagc gcccaguccg ccuucgaggg guucccccag     1320

agcccccugc agaucccggu guccagcucc uucagcuaca cgcugcucuc ccuguuccag     1380

agcagccccg agcgcaccca cuccaccuuc gagggcuucc cccagagccc gcugcagauc     1440

cccgucucca gcuccagcuc cagcuccacc cuccugagcc uguuccaguc cagccccgag     1500

ugcacgcagu ccaccuucga gggcuucccc cagagcccgc uccagauccc ccaguccccg     1560

cccgaggggg agaacaccca cagcccccug cagaucgugc ccucccugcc cgagugggag     1620

gacagccuga gcccccacua cuucccgcag uccccgcccc agggcgagga cagccucagc     1680

ccccacuacu ucccccaguc cccgccccag ggggaggacu cccugagccc ccacuacuuc     1740

ccccagagcc cccagggcga ggacucccug agcccccacu acuuccccca guccccgccc     1800

cagggggagg acuccaugag cccccucuac uucccccagu ccccgcugca gggcgaggag     1860

uuccagagcu cccugcagag ccccgugucc aucugcagcu ccagcacccc cuccagccuc     1920

ccgcagagcu uccccgaguc cagccagucc ccgcccgagg gccccgucca gagcccccug     1980

cacagccccc aguccccgcc cgaggggaug cacucccaga gcccccugca gucccccgag     2040

uccgcccccg agggcgagga cucccucagc ccgcugcaga ucccccagag cccccuggag     2100

ggggaggacu cccucuccag ccugcacuuc ccccaguccc cgcccgagug ggaggacagc     2160

cugagccccc uccacuuccc ccaguucccg ccccagggcg aggacuucca guccagccug     2220

cagucccccg ugagcaucug cuccagcucc acgagccugu cccuccccca gagcuucccg     2280

gagagccccc aguccccgcc cgaggggccc gcgcagagcc cccugcagcg gcccgugucc     2340

uccuucuuca gcuacacccu ggccucccuc cugcagagcu cccacgagag cccgcagagc     2400

ccgcccgagg gccccgccca gagcccccug cagucccccg ucuccagcuu ccccuccagc     2460

accuccagcu cccucagcca guccagcccc guguccagcu ucccguccag caccuccagc     2520

ucccugagca agagcucccc cgagagcccc cugcaguccc ccgugaucag cuucuccagc     2580

uccacgagcc ucuccccguu cagcgaggag uccagcuccc ccgucgacga guacaccagc     2640

uccagcgaca cccugcugga guccgacagc cucaccgacu ccgagagccu gaucgagagc     2700

gagccccugu ucaccuacac gcucgacgag aagguggacg agcuggcccg cuuccugcuc     2760

cugaaguacc aggugaagca gcccaucacc aaggccgaga ugcugaccaa cgucaucucc     2820

cgguacaccg gcuacuuccc ggugaucuuc cgcaaggcgc gggaguucau cgagauccuc     2880

uucgggauca gccugcgcga gguggacccc gacgacuccu acgucuucgu gaacacgcug     2940

gaccucacca gcgagggcug ccuguccgac gagcagggga ugagccagaa ccggcugcuc     3000

auccugaucc uguccaucau cuucaucaag ggcaccuacg ccagcgagga ggucaucugg     3060

gacgugcucu ccgggaucgg cgugcgcgcc ggccgggagc acuucgccuu cggggagccc     3120

cgcgagcugc ugaccaaggu cugggugcag gagcacuacc ucgaguaccg ggaggugccc     3180

aacagcuccc cgccccgcua cgaguuccug uggggccccc gggcccacag cgaggucauc     3240

aagcgcaagg ugguggaguu ccuggcgaug cucaagaaca cgguccccau caccuucccg     3300

uccagcuaca aggacgcccu gaaggacgug gaggagcgcg cccaggccau caucgacacc     3360

accgacgacu ccacggccac cgagagcgcg uccagcuccg ugaugagccc cagcuucucc     3420

agcgaguga                                                             3429


<210>  2347
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2347
augggcgaca aggacaugcc caccgccggc augcccuccc uccuccaguc cuccuccgag       60

uccccccagu ccugccccga gggcgaggac ucccaguccc cccuccagau cccccagucc      120

ucccccgagu ccgacgacac ccucuacccc cuccaguccc cccagucccg cuccgagggc      180

gaggacuccu ccgacccccu ccagcgcccc cccgagggca aggacuccca guccccccuc      240

cagauccccc aguccucccc cgagggcgac gacacccagu ccccccucca gaacucccag      300

uccucccccg agggcaagga cucccucucc ccccucgaga ucucccaguc cccccccgag      360

ggcgaggacg uccagucccc ccuccagaac cccgccuccu ccuucuucuc cuccgcccuc      420

cucuccaucu uccaguccuc ccccgagucc acccaguccc ccuucgaggg cuucccccag      480

uccguccucc agauccccgu cuccgccgcc uccuccucca cccucgucuc caucuuccag      540

uccucccccg aguccaccca gucccccuuc gagggcuucc cccagucccc ccuccagauc      600

cccgucuccc gcuccuucuc cuccacccuc cucuccaucu uccaguccuc ccccgagcgc      660

acccagucca ccuucgaggg cuucgcccag uccccccucc agauccccgu cucccccucc      720

uccuccucca cccuccucuc ccucuuccag uccuucuccg agcgcaccca guccaccuuc      780

gagggcuucg cccaguccuc ccuccagauc cccgucuccc ccuccuucuc cuccacccuc      840

gucucccucu uccaguccuc ccccgagcgc acccagucca ccuucgaggg cuucccccag      900

uccccccucc agauccccgu cuccuccucc uccuccucca cccuccucuc ccucuuccag      960

uccucccccg agcgcaccca cuccaccuuc gagggcuucc cccagucccu ccuccagauc     1020

cccaugaccu ccuccuucuc cuccacccuc cucuccaucu uccaguccuc ccccgagucc     1080

gcccagucca ccuucgaggg cuucccccag uccccccucc agauccccgg cucccccucc     1140

uucuccucca cccuccucuc ccucuuccag uccucccccg agcgcaccca cuccaccuuc     1200

gagggcuucc cccagucccc ccuccagauc cccaugaccu ccuccuucuc cuccacccuc     1260

cucuccaucc uccaguccuc ccccgagucc gcccaguccg ccuucgaggg cuucccccag     1320

uccccccucc agauccccgu cuccuccucc uucuccuaca cccuccucuc ccucuuccag     1380

uccucccccg agcgcaccca cuccaccuuc gagggcuucc cccagucccc ccuccagauc     1440

cccgucuccu ccuccuccuc cuccuccacc cuccucuccc ucuuccaguc cucccccgag     1500

ugcacccagu ccaccuucga gggcuucccc cagucccccc uccagauccc ccaguccccc     1560

cccgagggcg agaacaccca cuccccccuc cagaucgucc ccucccuccc cgagugggag     1620

gacucccucu ccccccacua cuucccccag uccccccccc agggcgagga cucccucucc     1680

ccccacuacu ucccccaguc ccccccccag ggcgaggacu cccucucccc ccacuacuuc     1740

ccccaguccc cccagggcga ggacucccuc uccccccacu acuuccccca gucccccccc     1800

cagggcgagg acuccauguc cccccucuac uucccccagu ccccccucca gggcgaggag     1860

uuccaguccu cccuccaguc ccccgucucc aucugcuccu ccuccacccc cuccucccuc     1920

ccccaguccu uccccgaguc cucccagucc ccccccgagg gccccgucca guccccccuc     1980

cacucccccc aguccccccc cgagggcaug cacucccagu ccccccucca gucccccgag     2040

uccgcccccg agggcgagga cucccucucc ccccuccaga ucccccaguc cccccucgag     2100

ggcgaggacu cccucuccuc ccuccacuuc ccccaguccc cccccgagug ggaggacucc     2160

cucucccccc uccacuuccc ccaguucccc ccccagggcg aggacuucca guccucccuc     2220

cagucccccg ucuccaucug cuccuccucc accucccucu cccuccccca guccuucccc     2280

gagucccccc aguccccccc cgagggcccc gcccaguccc cccuccagcg ccccgucucc     2340

uccuucuucu ccuacacccu cgccucccuc cuccaguccu cccacgaguc cccccagucc     2400

ccccccgagg gccccgccca guccccccuc cagucccccg ucuccuccuu ccccuccucc     2460

accuccuccu cccucuccca guccuccccc gucuccuccu uccccuccuc caccuccucc     2520

ucccucucca aguccucccc cgaguccccc cuccaguccc ccgucaucuc cuucuccucc     2580

uccaccuccc ucucccccuu cuccgaggag uccuccuccc ccgucgacga guacaccucc     2640

uccuccgaca cccuccucga guccgacucc cucaccgacu ccgagucccu caucgagucc     2700

gagccccucu ucaccuacac ccucgacgag aaggucgacg agcucgcccg cuuccuccuc     2760

cucaaguacc aggucaagca gcccaucacc aaggccgaga ugcucaccaa cgucaucucc     2820

cgcuacaccg gcuacuuccc cgucaucuuc cgcaaggccc gcgaguucau cgagauccuc     2880

uucggcaucu cccuccgcga ggucgacccc gacgacuccu acgucuucgu caacacccuc     2940

gaccucaccu ccgagggcug ccucuccgac gagcagggca ugucccagaa ccgccuccuc     3000

auccucaucc ucuccaucau cuucaucaag ggcaccuacg ccuccgagga ggucaucugg     3060

gacguccucu ccggcaucgg cguccgcgcc ggccgcgagc acuucgccuu cggcgagccc     3120

cgcgagcucc ucaccaaggu cuggguccag gagcacuacc ucgaguaccg cgaggucccc     3180

aacuccuccc ccccccgcua cgaguuccuc uggggccccc gcgcccacuc cgaggucauc     3240

aagcgcaagg ucgucgaguu ccucgccaug cucaagaaca ccguccccau caccuucccc     3300

uccuccuaca aggacgcccu caaggacguc gaggagcgcg cccaggccau caucgacacc     3360

accgacgacu ccaccgccac cgaguccgcc uccuccuccg ucaugucccc cuccuucucc     3420

uccgaguga                                                             3429


<210>  2348
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2348
augggcgaca aggauaugcc caccgccggg augccuagcc ugcuccaguc cucuucagag       60

aguccacaaa gcugcccgga aggagaggac ucccagucuc cccuucagau cccucagucg      120

ucaccagaaa gcgaugacac acuguacccc uugcaaaguc cucaguccag aucugagggu      180

gaagauagcu ccgacccauu acagaggccc ccugagggca aagauucaca gaguccacug      240

caaauuccgc agagcucucc cgagggggac gauacucagu ccccucuaca gaacucacaa      300

agcaguccag aaggaaagga cucucucucc ccucuggaga uaagccaguc gcccccagaa      360

ggcgaggaug ugcagucucc ccuucaaaau ccggcuuccu cauucuuuag uagcgcacug      420

uuguccaucu uccagucuag cccugaguca acgcagaguc ccuuugaagg uuucccacag      480

uccguccucc aaauuccugu uagcgccgcg ucuucaagua cccuggugag caucuuucag      540

uccucucccg agucgacaca gagcccauuc gaaggguuuc cccagucccc ucugcaaauu      600

ccaguaucac ggaguuucuc uagcacucuc uuauccaucu uucagucaag cccggagcgc      660

acccagucua cauucgaagg auuugcucag uccccucugc aaauacccgu gaguccaucc      720

ucuuccucaa cccuuuugag ucuguuccag agcuuuucgg agcgaacuca guccacauuc      780

gagggcuucg cccagucuag ccuacaaauc cccgucucac cuaguuuuuc cucuacccuc      840

gugagccugu uccaguccuc accagaacgu acgcagagca cuuuugaggg cuucccccaa      900

aguccgcuuc agauuccugu uucuuccagc ucgucaucua cccuguugag ucucuuucag      960

uccagcccag aaagaacaca cucuacuuuc gagggguuuc cccagagccu guuacaaauc     1020

ccuaugaccu ccucauucag uagcacacug cucucuauuu uucaguccuc acccgaaagu     1080

gcacagagca ccuucgaggg auuuccacag uccccucuuc aaauccccgg uucuccaucg     1140

uucagcucaa cgcuguuguc ccuauuucag aguucuccgg agaggacuca uagcacauuc     1200

gaaggcuucc cucagucccc acugcagaua cccaugaccu caucuuuuag caguacucuc     1260

cuguccauuc uucaaagcuc ucccgaguca gcccaguccg cuuucgaagg guuuccucag     1320

aguccacugc aaauccccgu gagcucgucu uucuccuaua cauugcucag ccuguuucag     1380

ucaaguccug agcggaccca cucuacguuc gaaggauuuc cgcagucccc auuacagauu     1440

cccgucagcu caaguagcuc cucuagcacc cugcuauccc ucuuccaauc aucuccugag     1500

uguacacaga guacuuuuga gggcuuccca cagucgcccc ugcagauccc ucaaagcccg     1560

cccgaaggug agaacaccca uuccccacuu cagaucgugc cuucuuugcc cgaaugggag     1620

gacucacuga gcccacacua cuuuccucag uccccacccc agggggagga uagucucucu     1680

ccgcauuauu ucccucaauc acccccacag ggagaagaca gccugagccc ccacuacuuu     1740

ccucagaguc cacagggcga ggacagccuu ucuccccacu auuucccuca auccccgcca     1800

cagggcgaag auucaaugag cccccuguac uucccucagu cgcccuugca aggggaggaa     1860

uuucagucua gucuccaguc cccaguaagc auuugcucau ccucuacacc uagcagucug     1920

ccccaguccu ucccagagag cucucaauca ccuccggagg gacccguuca gaguccauua     1980

cauuccccuc agucuccccc agaagguaug cacagccagu cgccucugca aucacccgag     2040

agcgcaccgg aaggcgagga cucccuaagu ccacuccaga uaccucaguc uccccuggaa     2100

ggggaggaua gccuuuccuc auugcauuuu ccacagaguc ccccugagug ggaagacucu     2160

cugagcccgc uccacuuccc ccaauuucca ccucagggag aggauuucca guccucacug     2220

caaagccccg ugucuaucug uuccaguagc acuucguuau cccugccuca gucuuuucca     2280

gaaucacccc agagcccucc agagggcccc gcccagaguc cgcuucaacg cccugucucc     2340

ucuuucuuua gcuauaccuu ggcuucacuc cugcagucca gucacgaaag cccacagucu     2400

cccccugagg guccagccca gucaccccua caauccccgg ugagcucuuu cccuaguucg     2460

acauccagcu cacugucuca gagcuccccc gugaguucau uuccaucuag caccuccagu     2520

agccucucca aaucuucacc ugagagcccc cugcagucgc cagucauuuc cuucaguucu     2580

agcacuucac uuucccccuu cucugaagag aguagcuccc cuguugacga auacacguca     2640

agcucugaua cauugcugga gagugacucc uuaaccgaua gcgagucacu caucgaaucu     2700

gagccacugu uuacuuacac ccuugacgaa aagguggaug agcuggcgag auucuugcuc     2760

cugaaauauc agguaaagca accgauaaca aaggcagaaa ugcuaaccaa ugugauuucc     2820

agguacacug gguauuuucc cgucaucuuc cggaaagccc gcgaguuuau cgagauucug     2880

uucggcaucu cgcuccgaga aguggacccu gacgauagcu acguuuuugu gaacacacug     2940

gaccuuacga gugagggaug cuugucugau gaacagggca ugucccagaa uagacuguua     3000

auucucauac ugagcaucau uuucaucaag gggaccuaug cuucagagga agucaucugg     3060

gacgugcuua guggaauugg uguaagggcc ggccgggagc auuuugcauu cggggagcca     3120

cgugaacugc uaacuaaagu uugggugcag gagcacuacc ucgaauaucg cgaggucccc     3180

aacuccagcc cuccaagaua cgaauuucug uggggaccca gggcucauuc ugaggugaua     3240

aagcggaaag ucguggaguu cuuggccaug cugaagaaua caguuccuau caccuuuccg     3300

ucaagcuaca aggaugcguu aaaagacgug gaggaacgag cccaagcaau uaucgauaca     3360

acugacgauu ccaccgcuac ggaaucugcc aguucgagcg uaaugucccc aucauucucu     3420

agcgaguga                                                             3429


<210>  2349
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2349
augggcgaca aggacaugcc caccgccggc augcccagcc ugcugcagag cagcagcgag       60

agcccccaga gcugccccga gggcgaggac agccagagcc cccugcagau cccccagagc      120

agccccgaga gcgacgacac ccuguacccc cugcagagcc cccagagcag aagcgagggc      180

gaggacagca gcgacccccu gcagagaccc cccgagggca aggacagcca gagcccccug      240

cagauccccc agagcagccc cgagggcgac gacacccaga gcccccugca gaacagccag      300

agcagccccg agggcaagga cagccugagc ccccuggaga ucagccagag cccccccgag      360

ggcgaggacg ugcagagccc ccugcagaac cccgccagca gcuucuucag cagcgcccug      420

cugagcaucu uccagagcag ccccgagagc acccagagcc ccuucgaggg cuucccccag      480

agcgugcugc agauccccgu gagcgccgcc agcagcagca cccuggugag caucuuccag      540

agcagccccg agagcaccca gagccccuuc gagggcuucc cccagagccc ccugcagauc      600

cccgugagca gaagcuucag cagcacccug cugagcaucu uccagagcag ccccgagaga      660

acccagagca ccuucgaggg cuucgcccag agcccccugc agauccccgu gagccccagc      720

agcagcagca cccugcugag ccuguuccag agcuucagcg agagaaccca gagcaccuuc      780

gagggcuucg cccagagcag ccugcagauc cccgugagcc ccagcuucag cagcacccug      840

gugagccugu uccagagcag ccccgagaga acccagagca ccuucgaggg cuucccccag      900

agcccccugc agauccccgu gagcagcagc agcagcagca cccugcugag ccuguuccag      960

agcagccccg agagaaccca cagcaccuuc gagggcuucc cccagagccu gcugcagauc     1020

cccaugacca gcagcuucag cagcacccug cugagcaucu uccagagcag ccccgagagc     1080

gcccagagca ccuucgaggg cuucccccag agcccccugc agauccccgg cagccccagc     1140

uucagcagca cccugcugag ccuguuccag agcagccccg agagaaccca cagcaccuuc     1200

gagggcuucc cccagagccc ccugcagauc cccaugacca gcagcuucag cagcacccug     1260

cugagcaucc ugcagagcag ccccgagagc gcccagagcg ccuucgaggg cuucccccag     1320

agcccccugc agauccccgu gagcagcagc uucagcuaca cccugcugag ccuguuccag     1380

agcagccccg agagaaccca cagcaccuuc gagggcuucc cccagagccc ccugcagauc     1440

cccgugagca gcagcagcag cagcagcacc cugcugagcc uguuccagag cagccccgag     1500

ugcacccaga gcaccuucga gggcuucccc cagagccccc ugcagauccc ccagagcccc     1560

cccgagggcg agaacaccca cagcccccug cagaucgugc ccagccugcc cgagugggag     1620

gacagccuga gcccccacua cuucccccag agcccccccc agggcgagga cagccugagc     1680

ccccacuacu ucccccagag ccccccccag ggcgaggaca gccugagccc ccacuacuuc     1740

ccccagagcc cccagggcga ggacagccug agcccccacu acuuccccca gagccccccc     1800

cagggcgagg acagcaugag cccccuguac uucccccaga gcccccugca gggcgaggag     1860

uuccagagca gccugcagag ccccgugagc aucugcagca gcagcacccc cagcagccug     1920

ccccagagcu uccccgagag cagccagagc ccccccgagg gccccgugca gagcccccug     1980

cacagccccc agagcccccc cgagggcaug cacagccaga gcccccugca gagccccgag     2040

agcgcccccg agggcgagga cagccugagc ccccugcaga ucccccagag cccccuggag     2100

ggcgaggaca gccugagcag ccugcacuuc ccccagagcc cccccgagug ggaggacagc     2160

cugagccccc ugcacuuccc ccaguucccc ccccagggcg aggacuucca gagcagccug     2220

cagagccccg ugagcaucug cagcagcagc accagccuga gccugcccca gagcuucccc     2280

gagagccccc agagcccccc cgagggcccc gcccagagcc cccugcagag acccgugagc     2340

agcuucuuca gcuacacccu ggccagccug cugcagagca gccacgagag cccccagagc     2400

ccccccgagg gccccgccca gagcccccug cagagccccg ugagcagcuu ccccagcagc     2460

accagcagca gccugagcca gagcagcccc gugagcagcu uccccagcag caccagcagc     2520

agccugagca agagcagccc cgagagcccc cugcagagcc ccgugaucag cuucagcagc     2580

agcaccagcc ugagccccuu cagcgaggag agcagcagcc ccguggacga guacaccagc     2640

agcagcgaca cccugcugga gagcgacagc cugaccgaca gcgagagccu gaucgagagc     2700

gagccccugu ucaccuacac ccuggacgag aagguggacg agcuggccag auuccugcug     2760

cugaaguacc aggugaagca gcccaucacc aaggccgaga ugcugaccaa cgugaucagc     2820

agauacaccg gcuacuuccc cgugaucuuc agaaaggcca gagaguucau cgagauccug     2880

uucggcauca gccugagaga gguggacccc gacgacagcu acguguucgu gaacacccug     2940

gaccugacca gcgagggcug ccugagcgac gagcagggca ugagccagaa cagacugcug     3000

auccugaucc ugagcaucau cuucaucaag ggcaccuacg ccagcgagga ggugaucugg     3060

gacgugcuga gcggcaucgg cgugagagcc ggcagagagc acuucgccuu cggcgagccc     3120

agagagcugc ugaccaaggu gugggugcag gagcacuacc uggaguacag agaggugccc     3180

aacagcagcc cccccagaua cgaguuccug uggggcccca gagcccacag cgaggugauc     3240

aagagaaagg ugguggaguu ccuggccaug cugaagaaca ccgugcccau caccuucccc     3300

agcagcuaca aggacgcccu gaaggacgug gaggagagag cccaggccau caucgacacc     3360

accgacgaca gcaccgccac cgagagcgcc agcagcagcg ugaugagccc cagcuucagc     3420

agcgaguga                                                             3429


<210>  2350
<211>  3429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-C1__Homo_sapiens__CCDS35417.1

<400>  2350
augggcgaca aggauaugcc caccgccggg augccuagcc ugcuccaguc cucuagcgag       60

uccccgcaau cuugccccga aggagaggac agccaguccc cucugcagau cccccagucu      120

agcccugaau ccgaugacac acuuuacccc cugcaaagcc cucagucuag auccgagggc      180

gaagauagcu cugacccgcu ccagcggccc ccugagggga aagauuccca gagcccccug      240

caaauuccuc agucuucccc cgagggagac gauacgcaga gcccgcuuca gaacucccaa      300

ucuagcccug aaggcaagga cucccugagc ccccucgaga ucucucaguc cccucccgaa      360

ggggaggaug ugcagagccc ccugcaaaau ccugcuucua gcuucuuuuc cucugcccug      420

cucagcauuu uccaguccag cccggagucu acccaguccc ccuuugaagg auucccucag      480

agcguccugc aaauccccgu uucugcggcu uccagcucca cacuuguguc uauuuuucag      540

agcuccccug agucuaccca gagccccuuc gaaggcuuuc cgcagucccc ucugcaaauc      600

cccgugagcc gcucuuucuc cagcacacuc cugucuaucu uucaguccag cccugagaga      660

acccagucua cauucgaagg cuuugcccag agcccccuuc aaauuccugu cucccccucc      720

ucuuccagca cccugcucuc ccuguuccag ucuuuuagcg agcggacgca guccaccuuc      780

gagggguucg cccagucuag ccugcaaauc ccgguguccc cuucuuuuag cuccacacuc      840

guuagccugu uccagucuuc ccccgaacgc acccagagca cauuugaggg auucccccaa      900

ucuccucuuc agauuccggu guccuccucu uccagcucca cccugcucag ccuguuucag      960

ucuagccccg aaagaacgca cuccacauuc gagggcuuuc cucagucucu ucugcaaauc     1020

cccaugacca gcuccuucuc uagcacacuc cuguccauuu uucagucuag cccugaaucc     1080

gcucagagca ccuucgaggg guuuccccag ucuccucugc aaauccccgg auccccgagc     1140

uucucuucca cccuccugag ccuuuuucag uccucuccug agcggacaca uagcacguuc     1200

gaaggcuucc cccagucccc ucugcagauu cccaugacca gcucuuuuuc cagcacacuc     1260

cugucuaucc uucaaagcuc cccggagucu gcccagagcg cuuucgaagg guuuccucag     1320

uccccucugc aaauccccgu cucuagcucc uucagcuaua cccuccuguc ucuguuucag     1380

uccagccccg agcgcacaca cuccaccuuc gaaggauuuc cccagucucc ucuccagauu     1440

ccggugagcu ccucuagcuc cagcucuacg cugcuuuccc uguuccaaag cucucccgag     1500

uguacacagu ccaccuuuga gggcuucccu cagagccccc uccagauccc ucaaucuccc     1560

ccugaaggcg agaacaccca uagcccgcug cagauuguuc ccucccugcc ugaaugggag     1620

gacucucuua gcccccacua cuuuccucag uccccgcccc agggggagga uagccucucc     1680

ccucauuauu ucccccaauc ucccccucag ggagaagaca gccugucccc ucacuacuuu     1740

ccccagucuc cgcagggcga ggacagccug uccccucacu auuuccccca aucucccccu     1800

cagggggaag auagcaugag cccccucuac uucccgcaga gcccucugca aggagaggaa     1860

uuucagucuu cccuucagag ccccgugucu aucugcucca gcucuacacc uuccagccug     1920

ccccaguccu ucccugagag cucucaaagc ccgcccgagg gcccugucca gagcccccuc     1980

cauucucccc agagcccucc ggaagggaug cacucccagu cuccccugca aagcccugag     2040

uccgcccccg aaggagagga cucucugagc ccucuucaga uuccccaguc cccucucgaa     2100

ggcgaggaua gccugucuuc ccugcauuuu ccgcagagcc cucccgagug ggaagacucu     2160

cucagccccc ugcacuuccc ucaauuuccc ccgcagggcg aggauuucca guccucccuu     2220

caaucuccug ugagcaucug uuccagcucu accucccuga gccuccccca gucuuuuccc     2280

gaaagcccuc aguccccucc cgaggggccg gcgcagucuc cccugcaaag accugugagc     2340

uccuucuuuu cuuauacacu ggccagccuu cuccagucca gccacgaauc uccccagucc     2400

ccucccgagg gaccggcuca gagcccucug caaucccccg ucucuagcuu cccuuccucu     2460

acgagcucca gccugucuca guccagcccc guuucuuccu uuccuagcuc uaccuccagc     2520

ucucucagca aauccagccc cgaguccccg cugcagucuc cugugaucag cuucuccucu     2580

agcacauccc uuucucccuu cagcgaagag uccagcucuc ccguggacga auacaccucc     2640

agcucugaua cacugcucga guccgacagc cugaccgauu cugagucccu gauugaaagc     2700

gagccucuuu uuacguacac ccucgacgaa aaggucgaug agcuggcccg guuccugcuc     2760

cugaaauauc aggugaagca accgaucaca aaggcugaaa ugcuuaccaa uguuauuucu     2820

cgcuacacag gcuauuuucc cgugaucuuc agaaaagccc gggaguuuau ugagauccug     2880

uucgggaucu cccuccgcga agucgacccu gacgauagcu acguguuugu uaacacccug     2940

gaccugacga gcgagggaug ccuuuccgau gaacagggca ugucucagaa uagacugcuc     3000

auucugaucc ucagcauuau cuucauuaag gggacauaug cguccgagga agugaucugg     3060

gacguccugu cuggcauugg agugcgggcc ggccgcgagc auuuugcuuu cggggagccc     3120

agagaacuuc ugaccaaagu cugggugcag gagcacuacc ucgaauaucg ggagguuccu     3180

aacagcucuc ccccuagaua cgaauuucug uggggacccc gcgcccauuc cgaggugauc     3240

aagcggaaag ucguggaguu ccuggcuaug cuuaagaaua caguuccgau caccuuuccu     3300

agcuccuaca aggaugcccu gaaagacgug gaagagagag cccaagcuau uaucgauacc     3360

acagacgaua gcacggcgac cgaaucugcc uccagcucug ucaugucccc cagcuucucc     3420

ucugaguga                                                             3429


<210>  2351
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-C2__Homo_sapiens__Q9UBF1

<400>  2351

Met Pro Pro Val Pro Gly Val Pro Phe Arg Asn Val Asp Asn Asp Ser 
1               5                   10                  15      


Pro Thr Ser Val Glu Leu Glu Asp Trp Val Asp Ala Gln His Pro Thr 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Ala Ser Ser Ala Ser Ser Thr Leu Tyr Leu 
        35                  40                  45              


Val Phe Ser Pro Ser Ser Phe Ser Thr Ser Ser Ser Leu Ile Leu Gly 
    50                  55                  60                  


Gly Pro Glu Glu Glu Glu Val Pro Ser Gly Val Ile Pro Asn Leu Thr 
65                  70                  75                  80  


Glu Ser Ile Pro Ser Ser Pro Pro Gln Gly Pro Pro Gln Gly Pro Ser 
                85                  90                  95      


Gln Ser Pro Leu Ser Ser Cys Cys Ser Ser Phe Ser Trp Ser Ser Phe 
            100                 105                 110         


Ser Glu Glu Ser Ser Ser Gln Lys Gly Glu Asp Thr Gly Thr Cys Gln 
        115                 120                 125             


Gly Leu Pro Asp Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys 
    130                 135                 140                 


Val Ala Glu Leu Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu 
145                 150                 155                 160 


Pro Val Thr Glu Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp 
                165                 170                 175     


Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
            180                 185                 190         


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
        195                 200                 205             


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
    210                 215                 220                 


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
225                 230                 235                 240 


Gly Asn Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Val 
                245                 250                 255     


Gly Val Tyr Ala Gly Arg Glu His Phe Val Tyr Gly Glu Pro Arg Glu 
            260                 265                 270         


Leu Leu Thr Lys Val Trp Val Gln Gly His Tyr Leu Glu Tyr Arg Glu 
        275                 280                 285             


Val Pro His Ser Ser Pro Pro Tyr Tyr Glu Phe Leu Trp Gly Pro Arg 
    290                 295                 300                 


Ala His Ser Glu Ser Ile Lys Lys Lys Val Leu Glu Phe Leu Ala Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Val Pro Ser Ser Phe Pro Ser Trp Tyr Lys Asp Ala 
                325                 330                 335     


Leu Lys Asp Val Glu Glu Arg Val Gln Ala Thr Ile Asp Thr Ala Asp 
            340                 345                 350         


Asp Ala Thr Val Met Ala Ser Glu Ser Leu Ser Val Met Ser Ser Asn 
        355                 360                 365             


Val Ser Phe Ser Glu 
    370             


<210>  2352
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-C2__Homo_sapiens__AAF07210

<400>  2352
augccucccg uuccaggcgu uccauuccgc aacguugaca acgacucccc gaccucaguu       60

gaguuagaag acuggguaga ugcacagcau cccacagaug aggaagagga ggaagccucc      120

uccgccucuu ccacuuugua cuuaguauuu ucccccucuu cuuucuccac auccucuucu      180

cugauucuug gugguccuga ggaggaggag gugcccucug gugugauacc aaaucuuacc      240

gagagcauuc ccaguagucc uccacagggu ccuccacagg guccuuccca gaguccucug      300

agcuccugcu gcuccucuuu uucauggagc ucauucagug aggaguccag cagccagaaa      360

ggggaggaua caggcaccug ucagggccug ccagacagug aguccucuuu cacauauaca      420

cuagaugaaa agguggccga guuaguggag uuccugcucc ucaaauacga agcagaggag      480

ccuguaacag aggcagagau gcugaugauu gucaucaagu acaaagauua cuuuccugug      540

auacucaaga gagcccguga guucauggag cuucuuuuug gccuugcccu gauagaagug      600

ggcccugacc acuucugugu guuugcaaac acaguaggcc ucaccgauga ggguagugau      660

gaugagggca ugcccgagaa cagccuccug auuauuauuc ugagugugau cuucauaaag      720

ggcaacugug ccucugagga ggucaucugg gaagugcuga augcaguagg gguauaugcu      780

gggagggagc acuucgucua uggggagccu agggagcucc ucacuaaagu uugggugcag      840

ggacauuacc uggaguaucg ggaggugccc cacaguucuc cuccauauua ugaauuccug      900

ugggguccaa gagcccauuc agaaagcauc aagaagaaag uacuagaguu uuuagccaag      960

cugaacaaca cuguuccuag uuccuuucca uccugguaca aggaugcuuu gaaagaugug     1020

gaagagagag uccaggccac aauugauacc gcagaugaug ccacugucau ggccagugaa     1080

agccucagug ucauguccag caacgucucc uuuucugagu ga                        1122


<210>  2353
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-C2__Homo_sapiens__AAF07210

<400>  2353
augccgcccg ugcccggcgu ccccuuccgc aacguggaca acgacagccc caccuccgug       60

gagcuggagg acugggucga cgcccagcac cccaccgacg aggaggagga ggaggccagc      120

uccgcgagcu ccacgcucua ccugguguuc agccccucca gcuucuccac cagcuccagc      180

cugauccucg ggggccccga ggaggaggag gugcccuccg gggucauccc gaaccugacc      240

gagagcaucc ccuccagccc gccccagggc ccgccccagg ggcccuccca gagcccccug      300

uccagcugcu gcagcuccuu cagcuggucc agcuucuccg aggagagcuc cagccagaag      360

ggcgaggaca ccggcacgug ccaggggcuc ccggacuccg agagcuccuu caccuacacc      420

cuggacgaga agguggccga gcugguggag uuccuccugc ugaaguacga ggccgaggag      480

cccgucaccg aggccgagau gcucaugauc gugaucaagu acaaggacua cuuccccgug      540

auccugaagc gggcccgcga guucauggag cuccuguucg gccuggcgcu gaucgagguc      600

gggcccgacc acuucugcgu guucgccaac acggugggcc ucaccgacga ggggagcgac      660

gacgagggca ugccggagaa cucccugcug aucaucaucc ucagcgucau cuucaucaag      720

ggcaacugcg ccuccgagga ggugaucugg gaggugcuga acgccgucgg gguguacgcg      780

ggccgggagc acuucgugua cggggagccc cgcgagcugc ucaccaaggu cugggugcag      840

ggccacuacc uggaguaccg ggaggugccc cacagcuccc cgcccuacua cgaguuccug      900

uggggccccc gcgcccacag cgaguccauc aagaagaagg uccucgaguu ccuggccaag      960

cugaacaaca ccgugcccag cagcuucccc uccugguaca aggacgcccu caaggacguc     1020

gaggagcggg ugcaggccac gaucgacacc gcggacgacg ccaccgugau ggccagcgag     1080

ucccugagcg ucauguccag caacgugucc uucagcgagu ga                        1122


<210>  2354
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-C2__Homo_sapiens__AAF07210

<400>  2354
augccccccg uccccggcgu ccccuuccgc aacgucgaca acgacucccc caccuccguc       60

gagcucgagg acugggucga cgcccagcac cccaccgacg aggaggagga ggaggccucc      120

uccgccuccu ccacccucua ccucgucuuc ucccccuccu ccuucuccac cuccuccucc      180

cucauccucg gcggccccga ggaggaggag guccccuccg gcgucauccc caaccucacc      240

gaguccaucc ccuccucccc cccccagggc cccccccagg gccccuccca guccccccuc      300

uccuccugcu gcuccuccuu cuccuggucc uccuucuccg aggaguccuc cucccagaag      360

ggcgaggaca ccggcaccug ccagggccuc cccgacuccg aguccuccuu caccuacacc      420

cucgacgaga aggucgccga gcucgucgag uuccuccucc ucaaguacga ggccgaggag      480

cccgucaccg aggccgagau gcucaugauc gucaucaagu acaaggacua cuuccccguc      540

auccucaagc gcgcccgcga guucauggag cuccucuucg gccucgcccu caucgagguc      600

ggccccgacc acuucugcgu cuucgccaac accgucggcc ucaccgacga gggcuccgac      660

gacgagggca ugcccgagaa cucccuccuc aucaucaucc ucuccgucau cuucaucaag      720

ggcaacugcg ccuccgagga ggucaucugg gagguccuca acgccgucgg cgucuacgcc      780

ggccgcgagc acuucgucua cggcgagccc cgcgagcucc ucaccaaggu cuggguccag      840

ggccacuacc ucgaguaccg cgaggucccc cacuccuccc cccccuacua cgaguuccuc      900

uggggccccc gcgcccacuc cgaguccauc aagaagaagg uccucgaguu ccucgccaag      960

cucaacaaca ccguccccuc cuccuucccc uccugguaca aggacgcccu caaggacguc     1020

gaggagcgcg uccaggccac caucgacacc gccgacgacg ccaccgucau ggccuccgag     1080

ucccucuccg ucauguccuc caacgucucc uucuccgagu ga                        1122


<210>  2355
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-C2__Homo_sapiens__AAF07210

<400>  2355
augcccccug ugccaggcgu cccguucaga aacguugaca augauagccc caccuccgug       60

gagcuggaag acuggguaga ugcccagcac ccuacagacg aggaagagga agaggcuucu      120

ucagcaagua gcacucucua ccuuguguuu uccccaucuu cguucucaac gagcaguucc      180

cugaucuuag ggggacccga ggaagaggaa gucccuucug gugugauucc aaacuugacc      240

gagagcauac ccuccucacc uccacaaggc ccgccccagg ggccuaguca gagcccacug      300

ucuuccugcu guagcucauu uaguuggucu uccuucagcg aggaaucguc uucccagaag      360

ggagaggaua caggcacuug ccaaggucua cccgacucag aaaguagcuu uaccuauaca      420

cucgaugaga aaguugccga acugguggag uuccuucugu ugaaguacga ggcggaagaa      480

ccugucaccg aagcugagau gcucaugauc gugauuaaau auaaggacua cuuuccagua      540

auccugaaaa gggcccggga guucauggag cugcucuuug gguuagcacu gauugagguu      600

ggacccgauc auuucugugu guuugccaau acugucggcc uuacagacga aggcuccgau      660

gacgagggga ugccggaaaa cucuuugcug aucauaaucc uaagcgugau uuucaucaag      720

ggaaauugcg cuucagagga agugauuugg gagguccuca acgcaguugg uguguaugcc      780

ggccgcgagc acuuuguaua cggggaaccu cgagagcugc uuaccaaggu guggguccag      840

ggacauuauc uggaauaccg ugaggugccc cacaguuccc caccuuacua ugaguucuug      900

uggggcccca gagcucauag cgaaucuauc aaaaagaaag uucucgaguu ccuggccaag      960

uuaaauaaca cggugccauc aaguuuuccc agcugguaca aagaugcgcu gaaggacguc     1020

gaagagaggg ugcaggcaac uauagacacc gccgaugacg cuacaguaau ggccuccgaa     1080

ucucucucgg uuaugagcuc caauguguca uucagugagu ga                        1122


<210>  2356
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-C2__Homo_sapiens__AAF07210

<400>  2356
augccccccg ugcccggcgu gcccuucaga aacguggaca acgacagccc caccagcgug       60

gagcuggagg acugggugga cgcccagcac cccaccgacg aggaggagga ggaggccagc      120

agcgccagca gcacccugua ccugguguuc agccccagca gcuucagcac cagcagcagc      180

cugauccugg gcggccccga ggaggaggag gugcccagcg gcgugauccc caaccugacc      240

gagagcaucc ccagcagccc cccccagggc cccccccagg gccccagcca gagcccccug      300

agcagcugcu gcagcagcuu cagcuggagc agcuucagcg aggagagcag cagccagaag      360

ggcgaggaca ccggcaccug ccagggccug cccgacagcg agagcagcuu caccuacacc      420

cuggacgaga agguggccga gcugguggag uuccugcugc ugaaguacga ggccgaggag      480

cccgugaccg aggccgagau gcugaugauc gugaucaagu acaaggacua cuuccccgug      540

auccugaaga gagccagaga guucauggag cugcuguucg gccuggcccu gaucgaggug      600

ggccccgacc acuucugcgu guucgccaac accgugggcc ugaccgacga gggcagcgac      660

gacgagggca ugcccgagaa cagccugcug aucaucaucc ugagcgugau cuucaucaag      720

ggcaacugcg ccagcgagga ggugaucugg gaggugcuga acgccguggg cguguacgcc      780

ggcagagagc acuucgugua cggcgagccc agagagcugc ugaccaaggu gugggugcag      840

ggccacuacc uggaguacag agaggugccc cacagcagcc cccccuacua cgaguuccug      900

uggggcccca gagcccacag cgagagcauc aagaagaagg ugcuggaguu ccuggccaag      960

cugaacaaca ccgugcccag cagcuucccc agcugguaca aggacgcccu gaaggacgug     1020

gaggagagag ugcaggccac caucgacacc gccgacgacg ccaccgugau ggccagcgag     1080

agccugagcg ugaugagcag caacgugagc uucagcgagu ga                        1122


<210>  2357
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-C2__Homo_sapiens__AAF07210

<400>  2357
augcccccug ugccgggcgu ccccuucaga aacguugaca augauagccc uaccuccgug       60

gagcuggaag acugggugga ugcccagcac cccacagacg aggaagagga agaggcuucu      120

agcgccuccu cuacgcucua ccuggucuuu agcccuuccu cuuucagcac cuccagcucu      180

cuuauccucg ggggacccga ggaagaggaa gugccuuccg gcguuauucc gaaccugaca      240

gagagcaucc ccucuucccc uccccaaggg ccuccccagg gaccgagcca gucuccucug      300

uccagcugcu guuccucuuu uagcuggucc agcuucucug aggaauccag cucucagaag      360

ggcgaggaua ccgggacaug ccaaggacuu cccgacagcg aauccucuuu uaccuauaca      420

cuggaugaga aaguggcgga acucgucgag uuccugcugc ucaaguacga ggcugaagaa      480

ccugugaccg aagccgagau gcugaugauu guuaucaaau auaaggacua cuuucccgug      540

auucuuaaac gggcccgcga guucauggag cugcucuuug gccuggcucu uaucgagguc      600

ggccccgauc auuucugugu guuugccaau acgguggggc ugaccgacga aggaagcgau      660

gacgagggca ugccugaaaa cucccuccug aucauuaucc ugagcgucau uuucaucaag      720

gggaauugcg cuucugagga aguuauuugg gaggugcuca acgccguggg agucuaugcg      780

ggcagagagc acuuugugua cggggaaccg cgggagcugc uuacaaaggu uugggugcag      840

ggacauuauc uggaauaccg cgaggucccc cacuccagcc cucccuacua ugaguuccuc      900

uggggcccua gagcccauuc ugaauccauc aaaaagaaag ugcuggaguu ccuugcuaag      960

cugaauaaca ccguucccag cuccuuuccg ucuugguaca aagaugcccu caaggacgug     1020

gaggaacggg uccaggcuac aauugacacc gccgaugacg cgacggugau ggccagcgaa     1080

ucccugucug ucaugagcuc caaugugagc uucucugagu ga                        1122


<210>  2358
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-C3__Homo_sapiens__Q8TD91

<400>  2358

Met Leu Leu Pro Cys His Trp Val Leu Asp Ala Thr Phe Ser Asp Gly 
1               5                   10                  15      


Ser Leu Gly Gln Trp Val Lys Asn Thr Cys Ala Thr Tyr Ala Leu Ser 
            20                  25                  30          


Pro Val Val Leu Pro Pro Gln Pro Gln Pro Arg Lys Lys Ala Thr Asp 
        35                  40                  45              


Lys Asp Tyr Ser Ala Phe His Leu Gly His Leu Arg Glu Val Arg Leu 
    50                  55                  60                  


Phe Leu Arg Gly Gly Thr Ser Asp Gln Arg Met Asp Ser Leu Val Leu 
65                  70                  75                  80  


Cys Pro Thr Tyr Phe Lys Leu Trp Arg Thr Leu Ser Gly Ser Pro Gly 
                85                  90                  95      


Leu Gln Leu Ser Asp Leu His Phe Gly Ser Gln Pro Glu Gly Lys Phe 
            100                 105                 110         


Ser Leu Arg Arg Ala Val Ser Val Lys Gln Arg Glu Glu Pro Gln Asp 
        115                 120                 125             


Trp Pro Leu Asn Glu Lys Arg Thr Leu Trp Lys Asp Ser Asp Leu Pro 
    130                 135                 140                 


Thr Trp Arg Arg Gly Thr Gly Tyr Thr Leu Ser Leu Pro Ala Val Ser 
145                 150                 155                 160 


Pro Gly Lys Arg Leu Trp Gly Glu Lys Ala Gly Ser Leu Pro Glu Ser 
                165                 170                 175     


Glu Pro Leu Phe Thr Tyr Thr Leu Asp Glu Lys Val Asp Lys Leu Val 
            180                 185                 190         


Gln Phe Leu Leu Leu Lys Tyr Gln Ala Lys Glu Pro Leu Thr Arg Ala 
        195                 200                 205             


Glu Met Gln Met Asn Val Ile Asn Thr Tyr Thr Gly Tyr Phe Pro Met 
    210                 215                 220                 


Ile Phe Arg Lys Ala Arg Glu Phe Ile Glu Ile Leu Phe Gly Ile Ser 
225                 230                 235                 240 


Leu Thr Glu Val Asp Pro Asp His Phe Tyr Val Phe Val Asn Thr Leu 
                245                 250                 255     


Asp Leu Thr Cys Glu Gly Ser Leu Ser Asp Glu Gln Gly Met Pro Gln 
            260                 265                 270         


Asn Arg Leu Leu Ile Leu Ile Leu Ser Val Ile Phe Ile Lys Gly Asn 
        275                 280                 285             


Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Ile Gly Pro 
    290                 295                 300                 


Trp Ser Ala Leu Ala Gly Phe Ala Asp Val Leu Ser Arg Leu Ala Leu 
305                 310                 315                 320 


Trp Glu Ser Glu Gly Pro Glu Ala Phe Cys Glu Glu Ser Gly Leu Arg 
                325                 330                 335     


Ser Ala Glu Gly Ser Val Leu Asp Leu Ala Asn Pro Gln Gly Leu Ala 
            340                 345                 350         


Gly His Arg Gln Glu Asp Gly Arg Arg Gly Leu Thr Glu Ala Ser Pro 
        355                 360                 365             


Gln Gln Lys Lys Gly Gly Glu Asp Glu Asp Met Pro Ala Ala Gly Met 
    370                 375                 380                 


Pro Pro Leu Pro Gln Ser Pro Pro Glu Ile Pro Pro Gln Gly Pro Pro 
385                 390                 395                 400 


Lys Ile Ser Pro Gln Gly Pro Pro Gln Ser Pro Pro Gln Ser Pro Leu 
                405                 410                 415     


Asp Ser Cys Ser Ser Pro Leu Leu Trp Thr Arg Leu Asp Glu Glu Ser 
            420                 425                 430         


Ser Ser Glu Glu Glu Asp Thr Ala Thr Trp His Ala Leu Pro Glu Ser 
        435                 440                 445             


Glu Ser Leu Pro Arg Tyr Ala Leu Asp Glu Lys Val Ala Glu Leu Val 
    450                 455                 460                 


Gln Phe Leu Leu Leu Lys Tyr Gln Thr Lys Glu Pro Val Thr Lys Ala 
465                 470                 475                 480 


Glu Met Leu Thr Thr Val Ile Lys Lys Tyr Lys Asp Tyr Phe Pro Met 
                485                 490                 495     


Ile Phe Gly Lys Ala His Glu Phe Ile Glu Leu Ile Phe Gly Ile Ala 
            500                 505                 510         


Leu Thr Asp Met Asp Pro Asp Asn His Ser Tyr Phe Phe Glu Asp Thr 
        515                 520                 525             


Leu Asp Leu Thr Tyr Glu Gly Ser Leu Ile Asp Asp Gln Gly Met Pro 
    530                 535                 540                 


Lys Asn Cys Leu Leu Ile Leu Ile Leu Ser Met Ile Phe Ile Lys Gly 
545                 550                 555                 560 


Ser Cys Val Pro Glu Glu Val Ile Trp Glu Val Leu Ser Ala Ile Gly 
                565                 570                 575     


Pro Ile Gln Arg Pro Ala Arg Glu Val Leu Glu Phe Leu Ser Lys Leu 
            580                 585                 590         


Ser Ser Ile Ile Pro Ser Ala Phe Pro Ser Trp Tyr Met Asp Ala Leu 
        595                 600                 605             


Lys Asp Met Glu Asp Arg Ala Gln Ala Ile Ile Asp Thr Thr Asp Asp 
    610                 615                 620                 


Ala Thr Ala Met Ala Ser Ala Ser Pro Ser Val Met Ser Thr Asn Phe 
625                 630                 635                 640 


Cys Pro Glu 
            


<210>  2359
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-C3__Homo_sapiens__AAM08355

<400>  2359
augcugcugc ccugccacug gguguuggau gccaccuuca gugauggcag ucuaggccag       60

ugggugaaaa acacaugugc cacauaugcc uuauccccag uggugcuccc accucagccc      120

cagccccgga aaaaggccac agauaaggac uauucugccu uucaucuugg gcaucugagg      180

gaggugaggc uuuuucugag ggguggaacu ucagaucagc gaauggauag ucuuguccuc      240

ugccccacau acuucaagcu cuggaggacc cuaucagggu ccccagguuu acaacuuucu      300

gacuugcauu uugggaguca gccggagggg aaguuuucuc ugaggagggc aguuucaguu      360

aagcagaggg aggaacccca ggacuggcca cucaacgaga agagaacucu guggaaggac      420

agugaccuuc caacauggag gagaggcaca ggcuacaccc uuucccuucc ugccgucagc      480

ccuggaaaaa gguugugggg ggagaaagcg gggagcuugc cagagagcga gcccuuguuc      540

acuuauacac uggaugaaaa gguggacaag uuggugcagu uucuucuccu caaauaucaa      600

gcaaaagagc cucucacaag agcagagaug cagaugaaug ucaucaacac auacacgggc      660

uacuuuccua ugaucuucag gaaagcccgu gaguucauag agauucuuuu uggcauuucc      720

cugacagaag uggaccccga ccauuucuau gucuuuguaa acacauuaga ccucaccugu      780

gaggggaguc ugagugauga gcagggcaug ccccagaacc gccuccugau ucuuauucug      840

agugugaucu ucauaaaggg caacugugca ucugaggagg ucaucuggga agugcugaau      900

gcaauagggc ccuggucagc cuuggcaggg uucgcggaug ugcuuucccg acuugcacug      960

ugggagucug aaggaccuga agcauuuugc gaggagucug gacucagguc agcagaggga     1020

agcgucuuag accuggccaa uccucaagga cuugcaggcc acagacagga agauggccgc     1080

cgagggcuga ccgaggcguc cccacaacag aagaagggag gagaagauga ggauaugccu     1140

gcugcuggga ugccaccucu uccccagagu ccuccugaga uuccucccca ggguccuccc     1200

aagaucucuc cccagggucc uccgcagagu ccuccccaga guccucuaga cuccugcuca     1260

uccccucuuu uguggacccg auuggaugag gaguccagca gugaagagga ggauacagcu     1320

acuuggcaug ccuugccaga aagugaaucc uugcccaggu augcccugga ugaaaaggug     1380

gcugaguugg ugcaguuucu ucuccucaaa uaucaaacaa aagagccugu cacaaaggca     1440

gagaugcuga cgacugucau caagaaguau aaggacuauu uucccaugau cuucgggaaa     1500

gcccaugagu ucauagagcu aauuuuuggc auugcccuga cugauaugga ccccgacaac     1560

cacuccuauu ucuuugaaga cacauuagac cucaccuaug agggaagccu gauugaugac     1620

cagggcaugc ccaagaacug ucuccugauu cuuauucuca guaugaucuu cauaaagggc     1680

agcugugucc ccgaggaggu caucugggaa guguugagug caauagggcc cauucagagg     1740

ccagcaagag aagucuuaga guuuuuaucc aagcuaucca guaucauccc uagugccuuu     1800

ccauccuggu acauggaugc uuugaaagau auggaagaca gagcccaggc cauaauugac     1860

accacagaug augcuacugc cauggccagu gcaagcccca gugucauguc caccaacuuc     1920

uguccugagu ga                                                         1932


<210>  2360
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-C3__Homo_sapiens__AAM08355

<400>  2360
augcugcucc ccugccacug ggugcuggac gccaccuuca gcgacggcuc ccuggggcag       60

ugggucaaga acaccugcgc cacguacgcg cucagcccgg uggugcugcc cccccagccc      120

cagccgcgca agaaggccac cgacaaggac uacuccgccu uccaccuggg ccaccuccgg      180

gagguccgcc uguuccugcg ggggggcacc agcgaccagc gcauggacuc ccucgugcug      240

ugccccaccu acuucaagcu guggcggacg cucagcgggu cccccggccu gcagcugagc      300

gaccuccacu ucggcuccca gcccgagggg aaguucagcc ugcgccgggc cguguccguc      360

aagcagcgcg aggagccgca ggacuggccc cugaacgaga agcggacccu cuggaaggac      420

agcgaccugc ccaccuggcg ccggggcacc ggguacacgc ugucccuccc cgccgugagc      480

ccgggcaagc gccugugggg ggagaaggcg ggcucccugc ccgagagcga gccccucuuc      540

accuacaccc uggacgagaa gguggacaag cugguccagu uccuccugcu gaaguaccag      600

gccaaggagc cccucacccg ggccgagaug cagaugaacg ugaucaacac guacaccggc      660

uacuucccga ugaucuuccg caaggcccgg gaguucaucg agauccuguu cgggaucucc      720

cugaccgagg uggaccccga ccacuucuac gucuucguga acacccucga ccugacgugc      780

gagggcagcc uguccgacga gcaggggaug ccccagaacc gccuccugau ccugauccuc      840

agcgugaucu ucaucaaggg caacugcgcg agcgaggagg ucaucuggga ggugcugaac      900

gccaucggcc ccugguccgc ccuggccggg uucgccgacg ugcucagccg gcuggcgcug      960

ugggaguccg agggcccgga ggccuucugc gaggagagcg ggcuccgcuc cgccgagggc     1020

agcguccugg accuggccaa cccccagggg cucgccggcc accggcagga ggacggccgc     1080

cgggggcuga ccgaggcguc cccccagcag aagaagggcg gggaggacga ggacaugccc     1140

gccgccggca ugccgccccu gccccagagc cccccggaga ucccccccca ggggccgccc     1200

aagaucuccc cccagggccc cccgcagagc cccccccagu ccccccugga cagcugcucc     1260

agcccgcucc uguggacccg ccuggacgag gaguccagcu ccgaggagga ggacaccgcc     1320

acguggcacg cccuccccga gagcgagucc cugccccgcu acgcgcugga cgagaaggug     1380

gccgagcucg ugcaguuccu gcugcucaag uaccagacca aggagcccgu caccaaggcc     1440

gagaugcuga ccacggugau caagaaguac aaggacuacu ucccgaugau cuucggcaag     1500

gcccacgagu ucaucgagcu gaucuucggg aucgcccuca ccgacaugga ccccgacaac     1560

cacagcuacu ucuucgagga cacccuggac cugaccuacg agggcagccu caucgacgac     1620

caggggaugc ccaagaacug ccugcugauc cucauccugu ccaugaucuu caucaagggc     1680

agcugcgugc ccgaggaggu caucugggag gugcuguccg cgaucgggcc gauccagcgg     1740

cccgcccgcg agguccucga guuccugagc aagcugucca gcaucauccc cuccgccuuc     1800

cccagcuggu acauggacgc ccucaaggac auggaggacc gggcgcaggc caucaucgac     1860

acgaccgacg acgccaccgc cauggccucc gcgagcccgu ccgugaugag caccaacuuc     1920

ugccccgagu ga                                                         1932


<210>  2361
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-C3__Homo_sapiens__AAM08355

<400>  2361
augcuccucc ccugccacug gguccucgac gccaccuucu ccgacggcuc ccucggccag       60

ugggucaaga acaccugcgc caccuacgcc cucucccccg ucguccuccc cccccagccc      120

cagccccgca agaaggccac cgacaaggac uacuccgccu uccaccucgg ccaccuccgc      180

gagguccgcc ucuuccuccg cggcggcacc uccgaccagc gcauggacuc ccucguccuc      240

ugccccaccu acuucaagcu cuggcgcacc cucuccggcu cccccggccu ccagcucucc      300

gaccuccacu ucggcuccca gcccgagggc aaguucuccc uccgccgcgc cgucuccguc      360

aagcagcgcg aggagcccca ggacuggccc cucaacgaga agcgcacccu cuggaaggac      420

uccgaccucc ccaccuggcg ccgcggcacc ggcuacaccc ucucccuccc cgccgucucc      480

cccggcaagc gccucugggg cgagaaggcc ggcucccucc ccgaguccga gccccucuuc      540

accuacaccc ucgacgagaa ggucgacaag cucguccagu uccuccuccu caaguaccag      600

gccaaggagc cccucacccg cgccgagaug cagaugaacg ucaucaacac cuacaccggc      660

uacuucccca ugaucuuccg caaggcccgc gaguucaucg agauccucuu cggcaucucc      720

cucaccgagg ucgaccccga ccacuucuac gucuucguca acacccucga ccucaccugc      780

gagggcuccc ucuccgacga gcagggcaug ccccagaacc gccuccucau ccucauccuc      840

uccgucaucu ucaucaaggg caacugcgcc uccgaggagg ucaucuggga gguccucaac      900

gccaucggcc ccugguccgc ccucgccggc uucgccgacg uccucucccg ccucgcccuc      960

ugggaguccg agggccccga ggccuucugc gaggaguccg gccuccgcuc cgccgagggc     1020

uccguccucg accucgccaa cccccagggc cucgccggcc accgccagga ggacggccgc     1080

cgcggccuca ccgaggccuc cccccagcag aagaagggcg gcgaggacga ggacaugccc     1140

gccgccggca ugcccccccu cccccagucc ccccccgaga ucccccccca gggccccccc     1200

aagaucuccc cccagggccc cccccagucc cccccccagu ccccccucga cuccugcucc     1260

uccccccucc ucuggacccg ccucgacgag gaguccuccu ccgaggagga ggacaccgcc     1320

accuggcacg cccuccccga guccgagucc cucccccgcu acgcccucga cgagaagguc     1380

gccgagcucg uccaguuccu ccuccucaag uaccagacca aggagcccgu caccaaggcc     1440

gagaugcuca ccaccgucau caagaaguac aaggacuacu uccccaugau cuucggcaag     1500

gcccacgagu ucaucgagcu caucuucggc aucgcccuca ccgacaugga ccccgacaac     1560

cacuccuacu ucuucgagga cacccucgac cucaccuacg agggcucccu caucgacgac     1620

cagggcaugc ccaagaacug ccuccucauc cucauccucu ccaugaucuu caucaagggc     1680

uccugcgucc ccgaggaggu caucugggag guccucuccg ccaucggccc cauccagcgc     1740

cccgcccgcg agguccucga guuccucucc aagcucuccu ccaucauccc cuccgccuuc     1800

cccuccuggu acauggacgc ccucaaggac auggaggacc gcgcccaggc caucaucgac     1860

accaccgacg acgccaccgc cauggccucc gccucccccu ccgucauguc caccaacuuc     1920

ugccccgagu ga                                                         1932


<210>  2362
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-C3__Homo_sapiens__AAM08355

<400>  2362
augcugcucc ccugccacug ggugcuugac gccaccuuca gcgauggcuc ccuggggcag       60

ugggucaaga acacaugugc uacuuacgca uugucuccug uuguguuacc accgcaaccc      120

cagccucgga aaaaggccac ggacaaagau uauucagcgu uucaucuggg acaccuaagg      180

gagguaagac ucuuccugcg cgguggcacc agugaccagc gaauggauag ccuugugcug      240

ugcccaacau acuuuaaguu guggcguacu cucuccgggu cucccggacu gcagcugucg      300

gaccuccauu ucggcucaca accugaaggu aaauuuagcu uaagaagggc ugucagugug      360

aagcagcggg aggaaccaca ggauuggccc cugaaugaga agcgcacccu uuggaaagac      420

uccgauuugc cuacauggag aagggggacc ggauauacuc ugucucuacc agccguuagc      480

ccgggcaagc ggcucugggg cgaaaaagca gggucccugc ccgagucaga gccucuuuuc      540

acauacaccc uggacgaaaa gguggauaaa uugguccagu uucuccuguu aaaguaucaa      600

gccaaggagc cacugacgcg cgcugaaaug cagaugaacg ugaucaauac uuacaccgga      660

uauuucccca ugauuuuucg aaaagcaaga gaguucauag agauccucuu ugguauuagu      720

cuuacagaag uagacccuga ucacuucuac guuuuuguga acacucugga cuugaccugu      780

gagggcagcc uaucugacga acaggggaug ccacagaaua ggcugcucau ccugauucuu      840

uccgucaucu ucauaaaggg aaacugcgcc ucagaggaag ugaucuggga ggugcugaau      900

gcuauuggcc ccuggagcgc cuuggcgggu uucgcagaug uccucagucg gcuggccuua      960

ugggagucug aagggccgga ggcuuuuugu gaagaguccg gacugcguag cgccgaaggc     1020

ucgguucuag accucgcaaa cccucaaggc cuggcugggc aucgccagga ggauggaaga     1080

aggggucuua cagaggccuc uccccagcag aaaaagggcg gggaagacga ggauaugcca     1140

gcggccggaa ugccucccuu gccacaauca cccccugaaa ucccaccgca gggcccuccc     1200

aaaauuuccc cacagggucc cccucaaagu ccaccccaga gcccgcugga cuccugcucu     1260

agcccucucc uguggacccg gcuugaugag gaaucaaguu ccgaggagga agacacggca     1320

acuuggcacg cucugccaga gagcgaaucu uugccccgau acgcccucga ugagaaggug     1380

gcugagcugg uacaguucuu acugcuaaaa uaucagacaa aggaaccugu gaccaaggcc     1440

gagaugcuca cuacagucau caaaaaguac aaagacuauu uucccaugau auucgggaag     1500

gcacacgaau uuauugagcu gaucuucggc auugcccuua ccgauaugga cccagacaau     1560

cauucauacu uuuucgaaga uacguuggac cugaccuaug agggaagucu caucgaugac     1620

caaggcaugc cuaaaaacug ucuguuaauc cugauucuua gcaugauauu uaucaagggg     1680

uccugcgugc ccgaggaagu uauuugggag guguugucug cuaucggacc aauacagcgc     1740

ccggcgagag aaguccucga guuccugucg aagcuaagcu ccauuauccc uucagcauuu     1800

cccaguuggu acauggaugc ccugaaagac auggaagaua gggcucaggc caucauugac     1860

acaacugaug acgcaaccgc cauggcuucu gccagcccau ccgugauguc aacaaauuuc     1920

ugucccgagu ga                                                         1932


<210>  2363
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-C3__Homo_sapiens__AAM08355

<400>  2363
augcugcugc ccugccacug ggugcuggac gccaccuuca gcgacggcag ccugggccag       60

ugggugaaga acaccugcgc caccuacgcc cugagccccg uggugcugcc cccccagccc      120

cagcccagaa agaaggccac cgacaaggac uacagcgccu uccaccuggg ccaccugaga      180

gaggugagac uguuccugag aggcggcacc agcgaccaga gaauggacag ccuggugcug      240

ugccccaccu acuucaagcu guggagaacc cugagcggca gccccggccu gcagcugagc      300

gaccugcacu ucggcagcca gcccgagggc aaguucagcc ugagaagagc cgugagcgug      360

aagcagagag aggagcccca ggacuggccc cugaacgaga agagaacccu guggaaggac      420

agcgaccugc ccaccuggag aagaggcacc ggcuacaccc ugagccugcc cgccgugagc      480

cccggcaaga gacugugggg cgagaaggcc ggcagccugc ccgagagcga gccccuguuc      540

accuacaccc uggacgagaa gguggacaag cuggugcagu uccugcugcu gaaguaccag      600

gccaaggagc cccugaccag agccgagaug cagaugaacg ugaucaacac cuacaccggc      660

uacuucccca ugaucuucag aaaggccaga gaguucaucg agauccuguu cggcaucagc      720

cugaccgagg uggaccccga ccacuucuac guguucguga acacccugga ccugaccugc      780

gagggcagcc ugagcgacga gcagggcaug ccccagaaca gacugcugau ccugauccug      840

agcgugaucu ucaucaaggg caacugcgcc agcgaggagg ugaucuggga ggugcugaac      900

gccaucggcc ccuggagcgc ccuggccggc uucgccgacg ugcugagcag acuggcccug      960

ugggagagcg agggccccga ggccuucugc gaggagagcg gccugagaag cgccgagggc     1020

agcgugcugg accuggccaa cccccagggc cuggccggcc acagacagga ggacggcaga     1080

agaggccuga ccgaggccag cccccagcag aagaagggcg gcgaggacga ggacaugccc     1140

gccgccggca ugcccccccu gccccagagc ccccccgaga ucccccccca gggccccccc     1200

aagaucagcc cccagggccc cccccagagc cccccccaga gcccccugga cagcugcagc     1260

agcccccugc uguggaccag acuggacgag gagagcagca gcgaggagga ggacaccgcc     1320

accuggcacg cccugcccga gagcgagagc cugcccagau acgcccugga cgagaaggug     1380

gccgagcugg ugcaguuccu gcugcugaag uaccagacca aggagcccgu gaccaaggcc     1440

gagaugcuga ccaccgugau caagaaguac aaggacuacu uccccaugau cuucggcaag     1500

gcccacgagu ucaucgagcu gaucuucggc aucgcccuga ccgacaugga ccccgacaac     1560

cacagcuacu ucuucgagga cacccuggac cugaccuacg agggcagccu gaucgacgac     1620

cagggcaugc ccaagaacug ccugcugauc cugauccuga gcaugaucuu caucaagggc     1680

agcugcgugc ccgaggaggu gaucugggag gugcugagcg ccaucggccc cauccagaga     1740

cccgccagag aggugcugga guuccugagc aagcugagca gcaucauccc cagcgccuuc     1800

cccagcuggu acauggacgc ccugaaggac auggaggaca gagcccaggc caucaucgac     1860

accaccgacg acgccaccgc cauggccagc gccagcccca gcgugaugag caccaacuuc     1920

ugccccgagu ga                                                         1932


<210>  2364
<211>  1932
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-C3__Homo_sapiens__AAM08355

<400>  2364
augcugcucc ccugccacug ggugcuggac gccaccuuca gcgauggcuc ccuugggcag       60

ugggucaaga acacaugugc uacguacgcc cugucuccug uugugcuccc gccccaaccu      120

cagccccgga aaaaggcgac cgacaaagau uauagcgcuu uucaucuggg acaccuuaga      180

gaggugcgcc uguuccucag aggcgggaca uccgaccagc ggauggauuc ucugguccug      240

ugcccuaccu acuuuaagcu cuggcgcaca cugagcggau cccccggccu ucagcugucu      300

gaccuccauu ucgggagcca accugaagga aaauuuuccc ugagacgggc cgugagcguu      360

aagcagcgcg aggaaccgca ggauuggccc cuuaaugaga agagaacccu guggaaagac      420

ucugaucucc cuacauggcg gcgcggcacc ggcuauacgc ugucccugcc cgccgugagc      480

ccugggaaga gacucugggg agaaaaagcu ggcucucugc ccgaguccga gccgcuuuuc      540

accuacacac uggacgaaaa ggucgauaaa cucgugcagu uucugcuucu gaaguaucaa      600

gccaaggagc cucucacccg ggcugaaaug cagaugaacg uuaucaauac auacaccggg      660

uauuucccca ugauuuuucg caaagccaga gaguucaucg agauucuguu uggaaucagc      720

cugacggaag uggacccuga ucacuucuac gucuuuguga acacacucga ccugaccugu      780

gagggcucuc uuuccgacga acaggggaug ccccagaauc ggcugcucau ucugauccuu      840

agcgugaucu ucauuaaggg aaacugcgcg uccgaggaag ucaucuggga gguucugaau      900

gccauuggcc ccuggucugc ucucgccggc uucgcugaug ugcugagccg ccuggcccuc      960

ugggaguccg aagggccuga ggcguuuugu gaagagagcg gacugagauc ugccgaaggc     1020

uccgugcuug accuggcuaa cccgcaaggg cucgccggac aucggcagga ggauggcaga     1080

cgcgggcuga cagaggcuag cccccagcag aaaaagggag gcgaagacga ggauaugccu     1140

gccgccggca ugcccccucu gccccaaucu ccgccugaaa uucccccuca ggggcccccu     1200

aaaaucagcc cccagggacc gccucaaucc ccuccccagu cuccccuuga cagcugcucc     1260

agcccgcucc uguggacccg gcuggaugag gaaucuucca gcgaggagga agacaccgcu     1320

acauggcacg cgcuccccga gucugaaucc cugccuagau acgcccuuga ugagaagguc     1380

gcugagcugg ugcaguuccu ccugcugaaa uaucagacga aggaacccgu uaccaaggcc     1440

gagaugcuua caaccgugau caaaaaguac aaagacuauu uuccuaugau uuucggcaag     1500

gcccacgaau uuaucgagcu caucuucggg auugcucuga cagauaugga ccccgacaau     1560

cauagcuacu uuuucgaaga uacccuggac cucacguaug agggaucccu gaucgaugac     1620

caaggcaugc cuaaaaacug ucuucugauu cucauccugu cuaugauuuu uaucaagggg     1680

agcugcgucc ccgaggaagu gaucugggag guucuguccg ccauuggccc gauccagcgc     1740

ccugcgcggg aagugcuuga guuccucucu aagcugagcu ccauuauccc cagcgcuuuu     1800

ccuucuuggu acauggaugc ccugaaagac auggaagaua gagcccaggc uauuaucgac     1860

acaaccgaug acgccaccgc uauggccucc gcgagccccu cugucauguc cacaaauuuc     1920

uguccggagu ga                                                         1932


<210>  2365
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-D1__Homo_sapiens__Q9Y5V3

<400>  2365

Met Ala Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Met Gln Thr Leu Met Glu 
            20                  25                  30          


Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Asn Gln Ala Thr Ala Ala 
        35                  40                  45              


Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala Asn Glu Met Ala Asp 
    50                  55                  60                  


Ile Gln Val Ser Ala Ala Ala Ala Arg Pro Lys Ser Ala Phe Lys Val 
65                  70                  75                  80  


Gln Asn Ala Thr Thr Lys Gly Pro Asn Gly Val Tyr Asp Phe Ser Gln 
                85                  90                  95      


Ala His Asn Ala Lys Asp Val Pro Asn Thr Gln Pro Lys Ala Ala Phe 
            100                 105                 110         


Lys Ser Gln Asn Ala Thr Pro Lys Gly Pro Asn Ala Ala Tyr Asp Phe 
        115                 120                 125             


Ser Gln Ala Ala Thr Thr Gly Glu Leu Ala Ala Asn Lys Ser Glu Met 
    130                 135                 140                 


Ala Phe Lys Ala Gln Asn Ala Thr Thr Lys Val Gly Pro Asn Ala Thr 
145                 150                 155                 160 


Tyr Asn Phe Ser Gln Ser Leu Asn Ala Asn Asp Leu Ala Asn Ser Arg 
                165                 170                 175     


Pro Lys Thr Pro Phe Lys Ala Trp Asn Asp Thr Thr Lys Ala Pro Thr 
            180                 185                 190         


Ala Asp Thr Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Thr Ser 
        195                 200                 205             


Gln Ala Asp Ile Glu Thr Asp Pro Gly Ile Ser Glu Pro Asp Gly Ala 
    210                 215                 220                 


Thr Ala Gln Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Leu Glu Ser 
225                 230                 235                 240 


Arg Thr Ile Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn 
                245                 250                 255     


Val Glu Glu Asn Ser Ser Gly Asp Gln Arg Arg Ala Pro Leu Ala Ala 
            260                 265                 270         


Gly Thr Trp Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro 
        275                 280                 285             


Gly Ala Pro Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn 
    290                 295                 300                 


Pro Ser Gly Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg 
305                 310                 315                 320 


Gln Ser Pro Pro Ala Arg Gln Thr Pro Pro Ala Trp Gln Asn Pro Val 
                325                 330                 335     


Ala Trp Gln Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn 
            340                 345                 350         


Pro Val Ile Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Val Val Trp 
        355                 360                 365             


Pro Asn Pro Leu Ala Trp Gln Asn Pro Pro Gly Trp Gln Thr Pro Pro 
    370                 375                 380                 


Gly Trp Gln Thr Pro Pro Gly Trp Gln Gly Pro Pro Asp Trp Gln Gly 
385                 390                 395                 400 


Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp 
                405                 410                 415     


Pro Leu Pro Thr Asp Trp Pro Leu Pro Pro Asp Trp Ile Pro Ala Asp 
            420                 425                 430         


Trp Pro Ile Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu 
        435                 440                 445             


Arg Pro Ser Pro Asn Ser Arg Ala Ser Gln Asn Pro Gly Ala Ala Gln 
    450                 455                 460                 


Pro Arg Asp Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys 
465                 470                 475                 480 


Tyr Leu Met Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu 
                485                 490                 495     


Met Leu Arg Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
            500                 505                 510         


Ile Glu Arg Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu 
        515                 520                 525             


Lys Glu Ile Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro 
    530                 535                 540                 


Glu Ser Leu Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu 
545                 550                 555                 560 


Gly Leu Leu Leu Val Ile Leu Gly Val Ile Phe Met Asn Gly Asn Arg 
                565                 570                 575     


Ala Ser Glu Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg 
            580                 585                 590         


Pro Gly Val Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr 
        595                 600                 605             


Tyr Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn 
    610                 615                 620                 


Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His 
625                 630                 635                 640 


Glu Thr Ser Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys 
                645                 650                 655     


Arg Asp Pro Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu 
            660                 665                 670         


Ala Leu Asp Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala 
        675                 680                 685             


Glu Ala Arg Thr Arg Met Gly Ile Gly Asp Glu Ala Val Ser Gly Pro 
    690                 695                 700                 


Trp Ser Trp Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu 
705                 710                 715                 720 


Gly Asp Phe Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala 
                725                 730                 735     


Arg Tyr His Gln Asn Ala Arg Ser Arg Phe Pro Gln Thr Phe Ala Gly 
            740                 745                 750         


Pro Ile Ile Gly Pro Gly Gly Thr Ala Ser Ala Asn Phe Ala Ala Asn 
        755                 760                 765             


Phe Gly Ala Ile Gly Phe Phe Trp Val Glu 
    770                 775             


<210>  2366
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-D1__Homo_sapiens__AAG23757

<400>  2366
auggcucaga aaauggacug uggugcgggc cuccucggcu uccaggcuga ggccuccgua       60

gaagacagcg ccuugcuuau gcagaccuug auggaggcca uccagaucuc agaggcucca      120

ccuacuaacc aggccaccgc agcugcuagu ccccagaguu cacagccccc aacugccaau      180

gagauggcug acauucaggu uucagcagcu gccgcuaggc cuaagucagc cuuuaaaguc      240

cagaaugcca ccacaaaagg cccaaauggu gucuaugauu ucucucaggc ucauaaugcc      300

aaggaugugc ccaacacgca gcccaaggca gccuuuaagu cccaaaaugc uaccccaaag      360

gguccaaaug cugccuauga uuuuucccag gcagcaacca cuggugaguu agcugcuaac      420

aagucugaga uggccuucaa ggcccagaau gccacuacua aagugggccc aaaugccacc      480

uacaauuucu cucagucucu caaugccaau gaccuggcca acagcaggcc uaagaccccu      540

uucaaggcuu ggaaugauac cacuaaggcc ccaacagcug auacccagac ccagaaugua      600

aaucaggcca aaauggccac uucccaggcu gacauagaga ccgacccagg uaucucugaa      660

ccugacggug caacugcaca gacaucagca gaugguuccc aggcucagaa ucuggagucc      720

cggacaauaa uucggggcaa gaggacccgc aagauuaaua acuugaaugu ugaagagaac      780

agcagugggg aucagaggcg ggccccacug gcugcaggga ccuggagguc ugcaccaguu      840

ccagugacca cucagaaccc accuggcgca ccccccaaug ugcucuggca gacgccauug      900

gcuuggcaga accccucagg cuggcaaaac cagacagcca ggcagacccc accagcacgu      960

cagagcccuc cagcuaggca gaccccacca gccuggcaga acccagucgc uuggcagaac     1020

ccagugauuu ggccaaaccc aguaaucugg cagaacccag ugaucuggcc aaaccccauu     1080

gucuggcccg gcccuguugu cuggccgaau ccacuggccu ggcagaaucc accuggaugg     1140

cagacuccac cuggauggca gaccccaccg ggcuggcagg guccuccaga cuggcaaggu     1200

ccuccugacu ggccgcuacc acccgacugg ccacugccac cugauuggcc acuucccacu     1260

gacuggccac uaccaccuga cuggaucccc gcugauuggc caauuccacc ugacuggcag     1320

aaccugcgcc ccucgccuaa ccugcgcccu ucucccaacu cgcgugccuc acagaaccca     1380

ggugcugcac agccccgaga uguggcccuu cuucaggaaa gagcaaauaa guuggucaag     1440

uacuugaugc uuaaggacua cacaaaggug cccaucaagc gcucagaaau gcugagagau     1500

aucauccgug aauacacuga uguuuaucca gaaaucauug aacgugcaug cuuuguccua     1560

gagaagaaau uugggauuca acugaaagaa auugacaaag aagaacaccu guauauucuc     1620

aucaguaccc ccgagucccu ggcuggcaua cugggaacga ccaaagacac acccaagcuc     1680

ggucuccucu uggugauucu gggugucauc uucaugaaug gcaaccgugc cagugaggcu     1740

guccucuggg aggcacuacg caagauggga cugcguccug gggugagaca uccccuccuu     1800

ggagaucuaa ggaaacuucu caccuaugag uuuguaaagc agaaauaccu ggacuacaga     1860

cgagugccca acagcaaccc cccggaguau gaguuccucu ggggccuccg uuccuaccau     1920

gagacuagca agaugaaagu gcugagauuc auugcagagg uucagaaaag agacccucgu     1980

gacuggacug cacaguucau ggaggcugca gaugaggccu uggaugcucu ggaugcugcu     2040

gcagcugagg ccgaagccag ggcugaagca agaacccgca ugggaauugg agaugaggcu     2100

gugucugggc ccuggagcug ggaugacauu gaguuugagc ugcugaccug ggaugaggaa     2160

ggagauuuug gagaucccug guccagaauu ccauuuaccu ucugggccag auaccaccag     2220

aaugcccgcu ccagauuccc ucagaccuuu gccgguccca uuauuggucc uggugguaca     2280

gccagugcca acuucgcugc caacuuuggu gccauugguu ucuucugggu ugaguga        2337


<210>  2367
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-D1__Homo_sapiens__AAG23757

<400>  2367
auggcccaga agauggacug cggcgccggg cugcucggcu uccaggcgga ggccagcgug       60

gaggacuccg cccugcugau gcagacccuc auggaggcca uccagaucag cgaggccccc      120

ccgaccaacc aggcgacggc cgccgccucc ccccagagcu cccagccccc caccgcgaac      180

gagauggccg acauccaggu cagcgccgcc gccgcgcgcc cgaaguccgc cuucaaggug      240

cagaacgcca ccaccaaggg gcccaacggc guguacgacu ucagccaggc ccacaacgcc      300

aaggacgucc ccaacacgca gcccaaggcg gccuucaagu cccagaacgc caccccgaag      360

gggcccaacg ccgccuacga cuucagccag gcggccacca ccggcgagcu ggccgccaac      420

aaguccgaga uggccuucaa ggcgcagaac gccacgacca aggugggccc caacgccacc      480

uacaacuuca gccagucccu gaacgccaac gaccucgcga acagccggcc caagaccccg      540

uucaaggccu ggaacgacac gaccaaggcc cccaccgccg acacccagac gcagaacgug      600

aaccaggcca agauggcgac cucccaggcc gacaucgaga ccgaccccgg gaucagcgag      660

cccgacggcg ccaccgccca gacguccgcc gacgggagcc aggcgcagaa ccuggagucc      720

cgcaccauca uccggggcaa gcgcacccgg aagaucaaca accugaacgu cgaggagaac      780

agcagcgggg accagcgccg ggccccgcuc gccgccggca ccuggcgcuc cgcccccgug      840

cccgugacga cccagaaccc cccgggcgcg ccccccaacg uccuguggca gaccccccug      900

gccuggcaga acccgagcgg guggcagaac cagaccgccc ggcagacgcc ccccgcccgc      960

cagucccccc cggcgcggca gacccccccc gccuggcaga acccgguggc cuggcagaac     1020

cccgugaucu ggcccaaccc cgucaucugg cagaacccgg ugaucuggcc caaccccauc     1080

guguggcccg gcccggucgu guggcccaac ccccucgccu ggcagaaccc cccggggugg     1140

cagacccccc ccggcuggca gacccccccg ggcuggcagg ggccccccga cuggcagggc     1200

cccccggacu ggccccugcc ccccgacugg ccgcugcccc ccgacuggcc gcuccccacg     1260

gacuggcccc ugcccccgga cuggaucccc gccgacuggc ccaucccccc ggacuggcag     1320

aaccugcgcc ccagccccaa ccuccggccc uccccgaaca gccgcgcguc ccagaacccc     1380

ggggccgccc agccccggga cguggcccug cugcaggagc gcgccaacaa gcucgucaag     1440

uaccugaugc ugaaggacua caccaaggug cccaucaagc ggagcgagau gcuccgcgac     1500

aucauccggg aguacaccga cguguacccg gagaucaucg agcgcgcgug cuucguccug     1560

gagaagaagu ucggcaucca gcugaaggag aucgacaagg aggagcaccu cuacauccug     1620

aucuccaccc ccgagagccu ggccgggauc cucggcacga ccaaggacac ccccaagcug     1680

ggccugcucc uggugauccu gggggugauc uucaugaacg gcaaccgggc cuccgaggcc     1740

guccucuggg aggcccugcg caagaugggg cugcgccccg gcgugcggca cccgcuccug     1800

ggggaccugc gcaagcuccu gaccuacgag uucgucaagc agaaguaccu ggacuaccgg     1860

cgcgugccca acagcaaccc ccccgaguac gaguuccucu ggggccugcg guccuaccac     1920

gagaccagca agaugaaggu gcugcgcuuc aucgcggagg uccagaagcg ggacccgcgc     1980

gacuggacgg cccaguucau ggaggccgcc gacgaggcgc ucgacgcccu ggacgccgcc     2040

gccgcggagg ccgaggcccg ggccgaggcc cgcacccgga ugggcaucgg ggacgaggcg     2100

guguccggcc ccuggagcug ggacgacauc gaguucgagc ugcugaccug ggacgaggag     2160

ggggacuucg gcgaccccug gucccgcauc cccuucaccu ucugggcccg guaccaccag     2220

aacgcccgca gccgguuccc gcagacguuc gccgggccca ucaucggccc cggcgggacc     2280

gccuccgcga acuucgccgc caacuucggc gccaucgggu ucuucugggu ggaguga        2337


<210>  2368
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-D1__Homo_sapiens__AAG23757

<400>  2368
auggcccaga agauggacug cggcgccggc cuccucggcu uccaggccga ggccuccguc       60

gaggacuccg cccuccucau gcagacccuc auggaggcca uccagaucuc cgaggccccc      120

cccaccaacc aggccaccgc cgccgccucc ccccaguccu cccagccccc caccgccaac      180

gagauggccg acauccaggu cuccgccgcc gccgcccgcc ccaaguccgc cuucaagguc      240

cagaacgcca ccaccaaggg ccccaacggc gucuacgacu ucucccaggc ccacaacgcc      300

aaggacgucc ccaacaccca gcccaaggcc gccuucaagu cccagaacgc cacccccaag      360

ggccccaacg ccgccuacga cuucucccag gccgccacca ccggcgagcu cgccgccaac      420

aaguccgaga uggccuucaa ggcccagaac gccaccacca aggucggccc caacgccacc      480

uacaacuucu cccagucccu caacgccaac gaccucgcca acucccgccc caagaccccc      540

uucaaggccu ggaacgacac caccaaggcc cccaccgccg acacccagac ccagaacguc      600

aaccaggcca agauggccac cucccaggcc gacaucgaga ccgaccccgg caucuccgag      660

cccgacggcg ccaccgccca gaccuccgcc gacggcuccc aggcccagaa ccucgagucc      720

cgcaccauca uccgcggcaa gcgcacccgc aagaucaaca accucaacgu cgaggagaac      780

uccuccggcg accagcgccg cgccccccuc gccgccggca ccuggcgcuc cgcccccguc      840

cccgucacca cccagaaccc ccccggcgcc ccccccaacg uccucuggca gaccccccuc      900

gccuggcaga accccuccgg cuggcagaac cagaccgccc gccagacccc ccccgcccgc      960

cagucccccc ccgcccgcca gacccccccc gccuggcaga accccgucgc cuggcagaac     1020

cccgucaucu ggcccaaccc cgucaucugg cagaaccccg ucaucuggcc caaccccauc     1080

gucuggcccg gccccgucgu cuggcccaac ccccucgccu ggcagaaccc ccccggcugg     1140

cagacccccc ccggcuggca gacccccccc ggcuggcagg gcccccccga cuggcagggc     1200

ccccccgacu ggccccuccc ccccgacugg ccccuccccc ccgacuggcc ccuccccacc     1260

gacuggcccc ucccccccga cuggaucccc gccgacuggc ccaucccccc cgacuggcag     1320

aaccuccgcc ccucccccaa ccuccgcccc ucccccaacu cccgcgccuc ccagaacccc     1380

ggcgccgccc agccccgcga cgucgcccuc cuccaggagc gcgccaacaa gcucgucaag     1440

uaccucaugc ucaaggacua caccaagguc cccaucaagc gcuccgagau gcuccgcgac     1500

aucauccgcg aguacaccga cgucuacccc gagaucaucg agcgcgccug cuucguccuc     1560

gagaagaagu ucggcaucca gcucaaggag aucgacaagg aggagcaccu cuacauccuc     1620

aucuccaccc ccgagucccu cgccggcauc cucggcacca ccaaggacac ccccaagcuc     1680

ggccuccucc ucgucauccu cggcgucauc uucaugaacg gcaaccgcgc cuccgaggcc     1740

guccucuggg aggcccuccg caagaugggc cuccgccccg gcguccgcca cccccuccuc     1800

ggcgaccucc gcaagcuccu caccuacgag uucgucaagc agaaguaccu cgacuaccgc     1860

cgcgucccca acuccaaccc ccccgaguac gaguuccucu ggggccuccg cuccuaccac     1920

gagaccucca agaugaaggu ccuccgcuuc aucgccgagg uccagaagcg cgacccccgc     1980

gacuggaccg cccaguucau ggaggccgcc gacgaggccc ucgacgcccu cgacgccgcc     2040

gccgccgagg ccgaggcccg cgccgaggcc cgcacccgca ugggcaucgg cgacgaggcc     2100

gucuccggcc ccugguccug ggacgacauc gaguucgagc uccucaccug ggacgaggag     2160

ggcgacuucg gcgaccccug gucccgcauc cccuucaccu ucugggcccg cuaccaccag     2220

aacgcccgcu cccgcuuccc ccagaccuuc gccggcccca ucaucggccc cggcggcacc     2280

gccuccgcca acuucgccgc caacuucggc gccaucggcu ucuucugggu cgaguga        2337


<210>  2369
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-D1__Homo_sapiens__AAG23757

<400>  2369
auggcccaga agauggacug cggcgcuggg cugcucggau uccaagcaga ggccagcgug       60

gaagauuccg cgcuucugau gcagaccuug auggaggcua uccagauuuc ugaagcaccc      120

ccuacaaacc aggccacugc cgcugcauca ccacaaagua gccagccgcc cacggccaau      180

gagauggcug acauacaggu cuccgccgcg gcagccagac cuaaaucugc uuuuaagguu      240

cagaacgcca ccacaaaagg uccaaauggc guguacgauu ucucgcaagc acacaacgcu      300

aaggacguac ccaauacuca gccuaaagcc gcguuuaagu cacagaacgc caccccaaag      360

gggcccaaug cagcuuauga uuucagccag gccgcuacaa ccggagaauu agccgcaaac      420

aaaagugaga uggccuuuaa ggcucaaaau gcgacuacaa aagugggccc uaacgcaacc      480

uacaauuucu cccagucucu gaacgccaau gaccuagcua acagcaggcc aaagacgccg      540

uuuaaagccu ggaaugauac uaccaaggca cccacagccg acacucagac ccaaaacguc      600

aaccaggcua agauggccac aucccaggca gauaucgaga ccgacccugg uauuucagaa      660

ccagaugggg cgacggcuca gacaagugcc gacggaagcc aagcacagaa ucucgagucu      720

cggacuauca uucgcggcaa acgaacccgu aagaucaaca aucugaacgu ggaagaaaau      780

uccucaggcg aucagagaag ggcuccccuu gccgccggga cuuggcggag cgcaccuguu      840

ccagugacaa cccagaaucc cccgggagcu ccucccaacg uccuguggca aacgccauug      900

gccuggcaga acccuagugg uuggcagaau cagaccgcgc gccaaacacc cccagccaga      960

cagucucccc cugcuaggca gacuccaccg gcauggcaga accccguggc cuggcaaaau     1020

ccuguaauau ggccaaaccc cguuaucugg cagaauccug ugauuuggcc aaaccccauc     1080

gucuggccgg gcccuguggu guggccaaau ccccucgcuu ggcagaaccc ucccgggugg     1140

caaaccccac cuggauggca gacaccccca ggcuggcagg guccgccuga cuggcagggg     1200

cccccagacu ggccccugcc uccagauugg ccccugccuc cggacuggcc acuccccacu     1260

gauuggccuu uaccacccga cuggauuccu gccgauuggc cgauaccccc agacuggcaa     1320

aaccugcggc cuucccccaa ucuucgccca agcccuaacu cgcgagcauc ucagaauccc     1380

ggagcggccc agccaagaga ugucgcuuug cugcaggaga gggccaacaa gcuaguuaaa     1440

uaucucaugc ugaaagacua caccaaggug ccgaucaaac gguccgagau gcuucgugau     1500

auuauccgcg aguauacaga cguauacccu gaaauuaucg agagagcaug uuucgugcug     1560

gaaaagaagu uuggcaucca auugaaagag auugauaagg aggaacaucu cuauauacug     1620

aucucaaccc ccgagaguuu agcuggcauu cuggggacua cgaaagacac accaaagcuc     1680

ggacuucugu uggucauccu aggugugaua uucaugaaug gcaacagggc cagcgaagca     1740

guucuguggg aggcccuccg gaaaaugggg cugcgacccg gagugcgcca cccucuucug     1800

ggcgacuuga gaaagcuccu gaccuacgaa uuugucaagc agaaauacuu agauuauagg     1860

cgggugccaa auuccaaucc cccugaguac gaguuccugu ggggucuacg cucuuaucau     1920

gaaacuagca agaugaaagu acucagauuu auugcugagg uucagaagag ggacccgcgu     1980

gauuggaccg cgcaguucau ggaagccgca gacgaggcuc uggaugcccu ugacgccgcu     2040

gcagccgaag cggaggcucg ggccgaggca cgaacaagaa uggggaucgg cgaugaagcc     2100

gugucaggac cauggaguug ggacgauauc gaguucgaau ugcugaccug ggacgaggag     2160

ggcgauuuug gggaccccug guccaggauu ccuuucacuu uuugggcucg cuaccaccaa     2220

aacgcacgga gcagauuccc ccagacauuu gccggaccaa ucauuggucc uggcgggacg     2280

gcgucugcua acuucgccgc aaauuuugga gccauaggcu ucuuuugggu cgaauga        2337


<210>  2370
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-D1__Homo_sapiens__AAG23757

<400>  2370
auggcccaga agauggacug cggcgccggc cugcugggcu uccaggccga ggccagcgug       60

gaggacagcg cccugcugau gcagacccug auggaggcca uccagaucag cgaggccccc      120

cccaccaacc aggccaccgc cgccgccagc ccccagagca gccagccccc caccgccaac      180

gagauggccg acauccaggu gagcgccgcc gccgccagac ccaagagcgc cuucaaggug      240

cagaacgcca ccaccaaggg ccccaacggc guguacgacu ucagccaggc ccacaacgcc      300

aaggacgugc ccaacaccca gcccaaggcc gccuucaaga gccagaacgc cacccccaag      360

ggccccaacg ccgccuacga cuucagccag gccgccacca ccggcgagcu ggccgccaac      420

aagagcgaga uggccuucaa ggcccagaac gccaccacca aggugggccc caacgccacc      480

uacaacuuca gccagagccu gaacgccaac gaccuggcca acagcagacc caagaccccc      540

uucaaggccu ggaacgacac caccaaggcc cccaccgccg acacccagac ccagaacgug      600

aaccaggcca agauggccac cagccaggcc gacaucgaga ccgaccccgg caucagcgag      660

cccgacggcg ccaccgccca gaccagcgcc gacggcagcc aggcccagaa ccuggagagc      720

agaaccauca ucagaggcaa gagaaccaga aagaucaaca accugaacgu ggaggagaac      780

agcagcggcg accagagaag agccccccug gccgccggca ccuggagaag cgcccccgug      840

cccgugacca cccagaaccc ccccggcgcc ccccccaacg ugcuguggca gaccccccug      900

gccuggcaga accccagcgg cuggcagaac cagaccgcca gacagacccc ccccgccaga      960

cagagccccc ccgccagaca gacccccccc gccuggcaga accccguggc cuggcagaac     1020

cccgugaucu ggcccaaccc cgugaucugg cagaaccccg ugaucuggcc caaccccauc     1080

guguggcccg gccccguggu guggcccaac ccccuggccu ggcagaaccc ccccggcugg     1140

cagacccccc ccggcuggca gacccccccc ggcuggcagg gcccccccga cuggcagggc     1200

ccccccgacu ggccccugcc ccccgacugg ccccugcccc ccgacuggcc ccugcccacc     1260

gacuggcccc ugccccccga cuggaucccc gccgacuggc ccaucccccc cgacuggcag     1320

aaccugagac ccagccccaa ccugagaccc agccccaaca gcagagccag ccagaacccc     1380

ggcgccgccc agcccagaga cguggcccug cugcaggaga gagccaacaa gcuggugaag     1440

uaccugaugc ugaaggacua caccaaggug cccaucaaga gaagcgagau gcugagagac     1500

aucaucagag aguacaccga cguguacccc gagaucaucg agagagccug cuucgugcug     1560

gagaagaagu ucggcaucca gcugaaggag aucgacaagg aggagcaccu guacauccug     1620

aucagcaccc ccgagagccu ggccggcauc cugggcacca ccaaggacac ccccaagcug     1680

ggccugcugc uggugauccu gggcgugauc uucaugaacg gcaacagagc cagcgaggcc     1740

gugcuguggg aggcccugag aaagaugggc cugagacccg gcgugagaca cccccugcug     1800

ggcgaccuga gaaagcugcu gaccuacgag uucgugaagc agaaguaccu ggacuacaga     1860

agagugccca acagcaaccc ccccgaguac gaguuccugu ggggccugag aagcuaccac     1920

gagaccagca agaugaaggu gcugagauuc aucgccgagg ugcagaagag agaccccaga     1980

gacuggaccg cccaguucau ggaggccgcc gacgaggccc uggacgcccu ggacgccgcc     2040

gccgccgagg ccgaggccag agccgaggcc agaaccagaa ugggcaucgg cgacgaggcc     2100

gugagcggcc ccuggagcug ggacgacauc gaguucgagc ugcugaccug ggacgaggag     2160

ggcgacuucg gcgaccccug gagcagaauc cccuucaccu ucugggccag auaccaccag     2220

aacgccagaa gcagauuccc ccagaccuuc gccggcccca ucaucggccc cggcggcacc     2280

gccagcgcca acuucgccgc caacuucggc gccaucggcu ucuucugggu ggaguga        2337


<210>  2371
<211>  2337
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-D1__Homo_sapiens__AAG23757

<400>  2371
auggcccaga agauggacug cggcgcuggg cugcucggau uccaagccga ggcgagcgug       60

gaagauuccg cucugcuuau gcagacccug auggaggcca uccagauuuc ugaagcuccc      120

ccuacaaacc aggcuacggc cgcugccagc ccgcaauccu cucagccccc uaccgcgaau      180

gagauggccg acauccaggu cagcgcugcc gcugccagac ccaaauccgc guuuaagguu      240

cagaacgcca caaccaaagg cccuaauggg guguacgauu ucucucaagc ucacaacgcc      300

aaggacgugc ccaauacaca gccuaaagcu gccuuuaaga gccagaacgc caccccgaag      360

ggacccaaug cugcguauga uuucucccag gccgcuacaa ccggcgaacu cgccgccaac      420

aaaagcgaga uggcuuuuaa ggcccaaaau gcgacgacca aagucgggcc uaacgcuaca      480

uacaauuucu cucagucccu gaacgccaau gaccuugcca acagccggcc caagaccccu      540

uuuaaagccu ggaaugauac aaccaaggcc cccacggcug acacacagac ccaaaacgug      600

aaccaggcca agauggcgac aucucaggcc gauauugaga ccgacccggg aaucuccgaa      660

ccugauggcg cuaccgccca gacaagcgcu gacggcucuc aagcccagaa ucuggagucc      720

cgcacgauua ucagagggaa acggacccgc aagaucaaca aucucaacgu ugaagagaau      780

agcuccggag aucagagacg ggcgccccug gccgcuggca cauggcgcuc ugccccugug      840

cccgucacca cacagaaucc cccuggggcu ccgcccaacg ugcuguggca aaccccucuc      900

gccuggcaga accccagcgg auggcagaau cagacggcca gacaaacacc ucccgcucgg      960

caguccccgc cugcgcgcca gaccccuccc gccuggcaga accccguugc uuggcaaaau     1020

ccugugauuu ggcccaaccc ggucaucugg cagaauccug ugauuuggcc caaccccauc     1080

guguggccug gcccggucgu uuggcccaau ccucuggccu ggcagaaucc cccugggugg     1140

caaaccccuc ccggauggca gacacccccg ggcuggcagg gcccucccga cuggcagggg     1200

ccucccgacu ggccgcuucc ucccgauugg ccucugccuc ccgacuggcc ccucccgacc     1260

gauuggcccc ugccucccga cuggauuccu gccgauuggc ccaucccucc ggacuggcaa     1320

aaccuuagac ccagcccuaa ccugcggccc ucuccuaacu cccgcgcuag ccagaauccc     1380

ggagccgcgc agccgagaga uguggcucuc cugcaggagc gggccaacaa acuggugaag     1440

uaucucaugc ugaaagacua cacaaagguc ccuauuaaac gcucugaaau gcuuagagau     1500

aucauccggg aguauacgga cguguacccc gaaauuaucg agagagccug uuucguucug     1560

gaaaagaagu uuggcauuca acucaaagag aucgauaagg aggaacaucu guauauucuu     1620

aucagcaccc ccgagucccu ggcugggauc cucggaacaa ccaaagacac accuaagcug     1680

ggccugcucc uggugauucu uggggucauc uucaugaaug gaaaccgcgc cucugaagcg     1740

gugcuguggg aggcucuccg gaaaaugggc cugagacccg gcguucgcca cccucuucug     1800

ggggaccucc ggaagcugcu gaccuacgaa uuugugaagc agaaauaccu cgauuauaga     1860

cgcgucccga auagcaaucc cccugaguac gaguuccugu ggggacuucg guccuaucau     1920

gaaacgagca agaugaaagu gcugagauuu auugccgagg uccagaagcg cgacccccgg     1980

gauuggaccg cccaguucau ggaagcugcc gacgaggcuc ucgaugcccu ggacgcggcc     2040

gcugccgaag cugaggccag agccgaggcu cgcacacgga ugggcaucgg ggaugaagcg     2100

gugucuggac cuugguccug ggacgauauu gaguucgaac ugcuuaccug ggacgaggag     2160

ggcgauuuug gggaccccug gagcagaauc ccguucacau uuugggcccg guaccaccaa     2220

aacgcucgcu cuagauuccc ucagaccuuu gccggcccca ucauuggacc uggcgggacg     2280

gccuccgcua acuucgccgc gaauuuugga gcuaucggcu ucuuuugggu ugaauga        2337


<210>  2372
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-D2__Homo_sapiens__Q9UNF1

<400>  2372

Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr 
            20                  25                  30          


Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala 
        35                  40                  45              


Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser 
    50                  55                  60                  


Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala 
65                  70                  75                  80  


Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala 
                85                  90                  95      


Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp 
            100                 105                 110         


Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His 
        115                 120                 125             


Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala 
    130                 135                 140                 


Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala 
145                 150                 155                 160 


Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys 
                165                 170                 175     


Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp 
            180                 185                 190         


Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala 
        195                 200                 205             


Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe 
    210                 215                 220                 


Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg 
225                 230                 235                 240 


Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg 
                245                 250                 255     


Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro 
            260                 265                 270         


Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys 
        275                 280                 285             


Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp 
    290                 295                 300                 


Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
305                 310                 315                 320 


Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu 
                325                 330                 335     


Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu 
            340                 345                 350         


Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys 
        355                 360                 365             


Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn 
    370                 375                 380                 


Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu 
385                 390                 395                 400 


Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile 
                405                 410                 415     


Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro 
            420                 425                 430         


Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr 
        435                 440                 445             


Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln 
    450                 455                 460                 


Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu 
465                 470                 475                 480 


Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg 
                485                 490                 495     


Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala 
            500                 505                 510         


Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys 
        515                 520                 525             


Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser 
    530                 535                 540                 


Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr 
                565                 570                 575     


Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala 
            580                 585                 590         


Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys 
        595                 600                 605     


<210>  2373
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-D2__Homo_sapiens__AAD28598

<400>  2373
augucugaca caagcgagag uggugcaggu cuaacucgcu uccaggcuga agcuucagaa       60

aaggacagua gcucgaugau gcagacucug uugacaguga cccagaaugu ggagguccca      120

gagacaccga aggccucaaa ggcacuggag gucucagagg augugaaggu cucaaaagcc      180

ucuggggucu caaaggccac agaggucuca aagaccccag aggcucggga ggcaccugcc      240

acccaggccu cgucuacuac ucagcugacu gauacccagg uucuggcagc ugaaaacaag      300

agucuagcag cugacaccaa gaaacagaau gcugacccgc aggcugugac aaugccugcc      360

acugagacca aaaaggucag ccauguggcu gauacgaagg ucaauacaaa ggcucaggag      420

acugaggcug cacccucuca ggccccagca gaugaaccug agccugagag ugcagcugcc      480

cagucucagg agaaucagga uacucggccc aaggucaaag ccaagaaagc ccgaaaggug      540

aagcaucugg auggggaaga ggauggcagc agugaucaga gucaggcuuc uggaaccaca      600

gguggccgaa gggucucaaa ggcucuaaug gccucaaugg cccgcagggc uucaaggggu      660

cccauagccu uuugggcccg cagggcauca aggacucggu uggcugcuug ggcccggaga      720

gccuugcucu cccugagauc accuaaagcc cguaggggca aggcucgccg uagagcugcc      780

aagcuccagu caucccaaga gccugaagca ccaccaccuc gggauguggc ccuuuugcaa      840

gggagggcaa augauuuggu gaaguaccuu uuggcuaaag accagacgaa gauucccauc      900

aagcgcucgg acaugcugaa ggacaucauc aaagaauaca cugaugugua ccccgaaauc      960

auugaacgag caggcuauuc uuuggagaag guauuuggga uucaauugaa ggaaauugau     1020

aagaaugacc acuuguacau ucuucucagc accuuagagc ccacugaugc aggcauacug     1080

ggaacgacua aggacucacc caagcugggu cugcucaugg ugcuucuuag caucaucuuc     1140

augaauggaa aucgguccag ugaggcuguc aucugggagg ugcugcgcaa guuggggcug     1200

cgcccuggga uacaucauuc acucuuuggg gacgugaaga agcucaucac ugaugaguuu     1260

gugaagcaga aguaccugga cuaugccaga guccccaaua gcaauccccc ugaauaugag     1320

uucuucuggg gccugcgcuc uuacuaugag accagcaaga ugaaaguccu caaguuugcc     1380

ugcaagguac aaaagaagga ucccaaggaa ugggcagcuc aguaccgaga ggcgauggaa     1440

gcggauuuga aggcugcagc ugaggcugca gcugaagcca aggcuagggc cgagauuaga     1500

gcucgaaugg gcauugggcu cggcucggag aaugcugccg ggcccugcaa cugggacgaa     1560

gcugauaucg gacccugggc caaagcccgg auccaggcgg gagcagaagc uaaagccaaa     1620

gcccaagaga guggcagugc cagcacuggu gccaguacca guaccaauaa cagugccagu     1680

gccagugcca gcaccagugg uggcuucagu gcuggugcca gccugaccgc cacucucaca     1740

uuugggcucu ucgcuggccu ugguggagcu ggugccagca ccaguggcag cucuggugcc     1800

ugugguuucu ccuacaagug a                                               1821


<210>  2374
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-D2__Homo_sapiens__AAD28598

<400>  2374
augagcgaca ccuccgagag cggcgccggg cugacccgcu uccaggccga ggcguccgag       60

aaggacagcu ccagcaugau gcagacgcug cugaccguga cccagaacgu cgaggugccc      120

gagaccccga aggccuccaa ggcccuggag gugagcgagg acgucaaggu guccaaggcc      180

agcggcgugu ccaaggccac ggaggucagc aagacccccg aggcgcggga ggcccccgcc      240

acccaggccu ccagcaccac gcagcucacc gacacccagg ugcuggcggc cgagaacaag      300

ucccuggccg ccgacaccaa gaagcagaac gccgaccccc aggcggugac gaugccggcc      360

accgagacca agaaggucag ccacguggcc gacaccaagg ugaacacgaa ggcccaggag      420

accgaggccg cgcccuccca ggcccccgcc gacgagcccg agccggagag cgccgccgcg      480

cagucccagg agaaccagga cacccgcccc aaggucaagg ccaagaaggc ccggaaggug      540

aagcaccucg acggggagga ggacggcagc agcgaccagu cccaggccag cgggaccacg      600

ggcggccgcc ggguguccaa ggcccugaug gcgagcaugg cccgccgggc cucccgcggg      660

cccaucgccu ucugggcgcg gcgcgccagc cggacccgcc uggccgccug ggcccggcgc      720

gcgcuccugu cccugcggag ccccaaggcc cgccggggca aggcccgccg gcgcgccgcc      780

aagcuccagu ccagccagga gccggaggcg cccccgcccc gggacgucgc ccugcugcag      840

gggcgcgcca acgaccucgu gaaguaccug cuggccaagg accagaccaa gauccccauc      900

aagcgcuccg acaugcucaa ggacaucauc aaggaguaca ccgacgugua ccccgagauc      960

aucgagcggg ccggcuacag ccuggagaag gucuucggga uccagcugaa ggagaucgac     1020

aagaacgacc accucuacau ccugcugucc acgcucgagc ccaccgacgc gggcauccug     1080

ggcaccacca aggacagccc caagcugggg cuccugaugg ugcugcucuc caucaucuuc     1140

augaacggca accgcagcuc cgaggccgug aucugggagg uccugcggaa gcuggggcuc     1200

cgcccgggca uccaccacag ccuguucggc gacgugaaga agcugaucac ggacgaguuc     1260

gugaagcaga aguaccucga cuacgcccgg guccccaacu ccaacccgcc cgaguacgag     1320

uucuucuggg ggcugcgcag cuacuacgag accagcaaga ugaaggugcu gaaguucgcc     1380

ugcaaggucc agaagaagga ccccaaggag ugggcggccc aguaccggga ggccauggag     1440

gccgaccuca aggccgcggc cgaggccgcc gccgaggcga aggcccgcgc cgagauccgg     1500

gcccgcaugg gcaucgggcu gggcuccgag aacgccgcgg ggcccugcaa cugggacgag     1560

gccgacaucg gccccugggc caaggcccgg auccaggcgg gcgccgaggc caaggccaag     1620

gcccaggaga gcggguccgc gagcaccggc gccuccacca gcacgaacaa cuccgccagc     1680

gccuccgcca gcaccuccgg gggcuucagc gcgggggccu cccugaccgc cacccucacg     1740

uucggccugu ucgccggccu cgggggcgcc ggggcgagca ccuccggcag cuccggggcc     1800

ugcggcuuca gcuacaagug a                                               1821


<210>  2375
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-D2__Homo_sapiens__AAD28598

<400>  2375
auguccgaca ccuccgaguc cggcgccggc cucacccgcu uccaggccga ggccuccgag       60

aaggacuccu ccuccaugau gcagacccuc cucaccguca cccagaacgu cgaggucccc      120

gagaccccca aggccuccaa ggcccucgag gucuccgagg acgucaaggu cuccaaggcc      180

uccggcgucu ccaaggccac cgaggucucc aagacccccg aggcccgcga ggcccccgcc      240

acccaggccu ccuccaccac ccagcucacc gacacccagg uccucgccgc cgagaacaag      300

ucccucgccg ccgacaccaa gaagcagaac gccgaccccc aggccgucac caugcccgcc      360

accgagacca agaaggucuc ccacgucgcc gacaccaagg ucaacaccaa ggcccaggag      420

accgaggccg cccccuccca ggcccccgcc gacgagcccg agcccgaguc cgccgccgcc      480

cagucccagg agaaccagga cacccgcccc aaggucaagg ccaagaaggc ccgcaagguc      540

aagcaccucg acggcgagga ggacggcucc uccgaccagu cccaggccuc cggcaccacc      600

ggcggccgcc gcgucuccaa ggcccucaug gccuccaugg cccgccgcgc cucccgcggc      660

cccaucgccu ucugggcccg ccgcgccucc cgcacccgcc ucgccgccug ggcccgccgc      720

gcccuccucu cccuccgcuc ccccaaggcc cgccgcggca aggcccgccg ccgcgccgcc      780

aagcuccagu ccucccagga gcccgaggcc cccccccccc gcgacgucgc ccuccuccag      840

ggccgcgcca acgaccucgu caaguaccuc cucgccaagg accagaccaa gauccccauc      900

aagcgcuccg acaugcucaa ggacaucauc aaggaguaca ccgacgucua ccccgagauc      960

aucgagcgcg ccggcuacuc ccucgagaag gucuucggca uccagcucaa ggagaucgac     1020

aagaacgacc accucuacau ccuccucucc acccucgagc ccaccgacgc cggcauccuc     1080

ggcaccacca aggacucccc caagcucggc cuccucaugg uccuccucuc caucaucuuc     1140

augaacggca accgcuccuc cgaggccguc aucugggagg uccuccgcaa gcucggccuc     1200

cgccccggca uccaccacuc ccucuucggc gacgucaaga agcucaucac cgacgaguuc     1260

gucaagcaga aguaccucga cuacgcccgc guccccaacu ccaacccccc cgaguacgag     1320

uucuucuggg gccuccgcuc cuacuacgag accuccaaga ugaagguccu caaguucgcc     1380

ugcaaggucc agaagaagga ccccaaggag ugggccgccc aguaccgcga ggccauggag     1440

gccgaccuca aggccgccgc cgaggccgcc gccgaggcca aggcccgcgc cgagauccgc     1500

gcccgcaugg gcaucggccu cggcuccgag aacgccgccg gccccugcaa cugggacgag     1560

gccgacaucg gccccugggc caaggcccgc auccaggccg gcgccgaggc caaggccaag     1620

gcccaggagu ccggcuccgc cuccaccggc gccuccaccu ccaccaacaa cuccgccucc     1680

gccuccgccu ccaccuccgg cggcuucucc gccggcgccu cccucaccgc cacccucacc     1740

uucggccucu ucgccggccu cggcggcgcc ggcgccucca ccuccggcuc cuccggcgcc     1800

ugcggcuucu ccuacaagug a                                               1821


<210>  2376
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-D2__Homo_sapiens__AAD28598

<400>  2376
augagcgaca ccuccgaguc uggcgccggg cugacaagau uccaggcuga agcaucagag       60

aaggauagua gcuccaugau gcaaacucuc cuuacgguga cccagaacgu cgaaguuccc      120

gagacaccua aagccucuaa ggcgcuggaa gugucggagg acguaaaagu gucaaaggcu      180

agcggaguca guaaagccac ugaggugucc aagaccccag aagcaaggga ggccccggcu      240

acacaggcau cuagcaccac ucaguugaca gauacccaag uuuuagccgc ugaaaauaag      300

ucccuggccg cggacacgaa aaagcagaac gcagaucccc aggccgugac uaugccugcu      360

accgagacua aaaaggucuc acacguggcc gacacuaaag uaaauaccaa ggcacaggag      420

acagaagcug ccccaaguca agcgcccgcc gaugagccug aaccagagag cgcagcugcc      480

cagucucagg aaaaccagga cacccggccc aagguuaaag cuaagaaagc ccgcaaggug      540

aaacaucuag auggugagga ggacggcucc ucagaucaaa gccaggcaag ugggacgacu      600

ggaggccgac gugucucuaa ggcccucaug gcuuccaugg cgagaagggc aagccggggu      660

ccuaucgccu uuugggcucg cagagccucg aggacacggc uggcagccug ggcucgccga      720

gcccuucugu cuuugagauc cccaaaagca aggcggggga aggcgcgucg cagagcugcc      780

aagcuccagu caagucaaga accggaggca cccccuccaa gggacguggc ccugcugcag      840

ggacgggcua augaucucgu gaaauacuua cuggccaagg accagaccaa aauucccaua      900

aagcgaagcg acaugcuuaa agauaucauu aaggaauaua cugacgucua cccugagauc      960

auugaacgcg caggcuauuc cuuggagaag guuuucggca uccagcugaa agagauagau     1020

aagaacgacc accuauacau ccuccugucu acacuugaac caaccgaugc ugggauucug     1080

ggaacgacca aagacagccc caaguugggu cuccugaugg uguuacuguc aaucauuuuu     1140

augaauggca acagaaguuc cgaggccgua aucugggaag ugcucaggaa acuugggcug     1200

cggccgggaa uacaucacag cuuguucggc gaugucaaga agcuaauuac agacgaguuu     1260

gugaaacaaa aguaucugga uuacgcgcgc guuccuaauu cuaauccccc agaauaugag     1320

uucuuuuggg gucucagauc auacuacgag acaaguaaaa ugaaggugcu gaaauucgcc     1380

ugcaaggucc agaagaaaga cccuaaggaa ugggcugcac aguauaggga ggccauggaa     1440

gcugaucuua aagccgcagc ggaggccgcu gccgaggcaa aggcucgugc cgaaauccgg     1500

gcacgaaugg ggauuggacu gggcagcgag aacgccgcug gccccuguaa cugggacgaa     1560

gcggacaucg ggccaugggc caaagcaaga auccaggcug gagccgaggc caaggcuaaa     1620

gcacaagaau ccgguucugc cucgaccggc gcgagcacau ccacuaauaa cucagcuagu     1680

gccucugcaa gcaccuccgg gggauuuuca gccggcgcua gcuugacagc aacccucacu     1740

uucggucugu uugccggguu aggcggagcg ggcgcuucua cguccgggag uagcggagcc     1800

ugcgguuucu cuuacaagug a                                               1821


<210>  2377
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-D2__Homo_sapiens__AAD28598

<400>  2377
augagcgaca ccagcgagag cggcgccggc cugaccagau uccaggccga ggccagcgag       60

aaggacagca gcagcaugau gcagacccug cugaccguga cccagaacgu ggaggugccc      120

gagaccccca aggccagcaa ggcccuggag gugagcgagg acgugaaggu gagcaaggcc      180

agcggcguga gcaaggccac cgaggugagc aagacccccg aggccagaga ggcccccgcc      240

acccaggcca gcagcaccac ccagcugacc gacacccagg ugcuggccgc cgagaacaag      300

agccuggccg ccgacaccaa gaagcagaac gccgaccccc aggccgugac caugcccgcc      360

accgagacca agaaggugag ccacguggcc gacaccaagg ugaacaccaa ggcccaggag      420

accgaggccg cccccagcca ggcccccgcc gacgagcccg agcccgagag cgccgccgcc      480

cagagccagg agaaccagga caccagaccc aaggugaagg ccaagaaggc cagaaaggug      540

aagcaccugg acggcgagga ggacggcagc agcgaccaga gccaggccag cggcaccacc      600

ggcggcagaa gagugagcaa ggcccugaug gccagcaugg ccagaagagc cagcagaggc      660

cccaucgccu ucugggccag aagagccagc agaaccagac uggccgccug ggccagaaga      720

gcccugcuga gccugagaag ccccaaggcc agaagaggca aggccagaag aagagccgcc      780

aagcugcaga gcagccagga gcccgaggcc ccccccccca gagacguggc ccugcugcag      840

ggcagagcca acgaccuggu gaaguaccug cuggccaagg accagaccaa gauccccauc      900

aagagaagcg acaugcugaa ggacaucauc aaggaguaca ccgacgugua ccccgagauc      960

aucgagagag ccggcuacag ccuggagaag guguucggca uccagcugaa ggagaucgac     1020

aagaacgacc accuguacau ccugcugagc acccuggagc ccaccgacgc cggcauccug     1080

ggcaccacca aggacagccc caagcugggc cugcugaugg ugcugcugag caucaucuuc     1140

augaacggca acagaagcag cgaggccgug aucugggagg ugcugagaaa gcugggccug     1200

agacccggca uccaccacag ccuguucggc gacgugaaga agcugaucac cgacgaguuc     1260

gugaagcaga aguaccugga cuacgccaga gugcccaaca gcaacccccc cgaguacgag     1320

uucuucuggg gccugagaag cuacuacgag accagcaaga ugaaggugcu gaaguucgcc     1380

ugcaaggugc agaagaagga ccccaaggag ugggccgccc aguacagaga ggccauggag     1440

gccgaccuga aggccgccgc cgaggccgcc gccgaggcca aggccagagc cgagaucaga     1500

gccagaaugg gcaucggccu gggcagcgag aacgccgccg gccccugcaa cugggacgag     1560

gccgacaucg gccccugggc caaggccaga auccaggccg gcgccgaggc caaggccaag     1620

gcccaggaga gcggcagcgc cagcaccggc gccagcacca gcaccaacaa cagcgccagc     1680

gccagcgcca gcaccagcgg cggcuucagc gccggcgcca gccugaccgc cacccugacc     1740

uucggccugu ucgccggccu gggcggcgcc ggcgccagca ccagcggcag cagcggcgcc     1800

ugcggcuuca gcuacaagug a                                               1821


<210>  2378
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-D2__Homo_sapiens__AAD28598

<400>  2378
augagcgaca ccuccgaguc uggcgccggg cugacaagau uccaggcuga agccagcgag       60

aaggauuccu cuagcaugau gcaaacgcuc cugaccguga cacagaacgu cgaaguuccc      120

gagaccccua aagcguccaa ggcucuugaa gugucugagg acgugaaagu cagcaaggcc      180

uccggaguga gcaaagccac agagguuucu aagaccccgg aagcucggga ggcccccgcu      240

acacaggccu ccagcaccac gcagcugacc gauacacaag ugcucgcggc cgaaaauaag      300

ucucuggcug ccgacaccaa aaagcagaac gcugauccuc aggccgucac aaugcccgcg      360

accgagacga aaaagguguc ccacguugcc gacacaaaag ugaauaccaa ggcucaggag      420

acagaagccg cuccuagcca agcccccgcc gaugagccug aaccggaguc ugcugcggcc      480

cagucccagg aaaaccagga cacccgcccc aaggucaaag cuaagaaagc cagaaaggug      540

aaacaucuug auggcgagga ggacgggagc uccgaucaau cucaggccag cggaaccaca      600

ggcgggcggc gcguguccaa ggcucugaug gccagcaugg cgagacgggc uucucgcgga      660

ccuaucgccu uuugggccag acgggcuucc cgcacgagac ucgccgcuug ggcccggcgc      720

gcgcugcuga gccucagauc ucccaaagcc cggcgcggca aggcuagacg gagagccgcu      780

aagcugcaga gcucccaaga accugaggcc ccgccgccuc gcgacgucgc gcuucugcag      840

ggccgggcca augaucucgu uaaauaccug cuugcuaagg accagaccaa aauucccauc      900

aagagaucug acaugcugaa agauauuauc aaggaauaua cagacgugua cccugagauu      960

aucgaacgcg ccggguauag ccucgagaag guguucggaa uccagcugaa agagauugau     1020

aagaacgacc accuguacau ccuccugucc acccuugaac ccacagaugc uggcauucug     1080

gggaccacga aagacagccc caagcucgga cugcuuaugg uccugcucuc uaucauuuuu     1140

augaauggca accgguccag cgaggccgug aucugggaag uucugagaaa acuggggcuc     1200

cgcccuggca uucaucacuc ucuguucgga gaugugaaga aacuuaucac agacgaguuu     1260

gucaagcaaa aguaucugga uuacgcccgg gugcccaauu ccaauccccc ugaauaugag     1320

uucuuuuggg gccucagaag cuacuacgag accuccaaaa ugaagguucu gaaauucgcu     1380

ugcaaggugc agaagaaaga ccccaaggaa ugggcggccc aguaucgcga ggcuauggaa     1440

gccgaucuua aagccgcugc cgaggcggcu gccgaggcca aggcucgggc cgaaaucaga     1500

gcgcgcaugg ggauuggacu gggcucugag aacgcugccg ggccuuguaa cugggacgaa     1560

gccgacaucg gacccugggc uaaagcccgg auucaggcug gcgccgaggc gaaggccaaa     1620

gcucaagaaa gcggguccgc cucuaccgga gcuagcacau ccaccaauaa cagcgccucu     1680

gccuccgcua gcacaucugg cggcuuuucc gcgggggcca gccucacggc uacccugaca     1740

uucggacugu uugccggccu cgggggagcc ggcgcuucua ccagcggguc cagcggcgcc     1800

ugcggauucu cuuacaagug a                                               1821


<210>  2379
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-D4__Homo_sapiens__Q96JG8

<400>  2379

Met Ala Glu Gly Ser Phe Ser Val Gln Ser Glu Ser Tyr Ser Val Glu 
1               5                   10                  15      


Asp Met Asp Glu Gly Ser Asp Glu Val Gly Glu Glu Glu Met Val Glu 
            20                  25                  30          


Gly Asn Asp Tyr Glu Glu Phe Gly Ala Phe Gly Gly Tyr Gly Thr Leu 
        35                  40                  45              


Thr Ser Phe Asp Ile His Ile Leu Arg Ala Phe Gly Ser Leu Gly Pro 
    50                  55                  60                  


Gly Leu Arg Ile Leu Ser Asn Glu Pro Trp Glu Leu Glu Asn Pro Val 
65                  70                  75                  80  


Leu Ala Gln Thr Leu Val Glu Ala Leu Gln Leu Asp Pro Glu Thr Leu 
                85                  90                  95      


Ala Asn Glu Thr Ala Ala Arg Ala Ala Asn Val Ala Arg Ala Ala Ala 
            100                 105                 110         


Ser Asn Arg Ala Ala Arg Ala Ala Ala Ala Ala Ala Arg Thr Ala Phe 
        115                 120                 125             


Ser Gln Val Val Ala Ser His Arg Val Ala Thr Pro Gln Val Ser Gly 
    130                 135                 140                 


Glu Asp Thr Gln Pro Thr Thr Tyr Ala Ala Glu Ala Gln Gly Pro Thr 
145                 150                 155                 160 


Pro Glu Pro Pro Leu Ala Ser Pro Gln Thr Ser Gln Met Leu Val Thr 
                165                 170                 175     


Ser Lys Met Ala Ala Pro Glu Ala Pro Ala Thr Ser Ala Gln Ser Gln 
            180                 185                 190         


Thr Gly Ser Pro Ala Gln Glu Ala Ala Thr Glu Gly Pro Ser Ser Ala 
        195                 200                 205             


Cys Ala Phe Ser Gln Ala Pro Cys Ala Arg Glu Val Asp Ala Asn Arg 
    210                 215                 220                 


Pro Ser Thr Ala Phe Leu Gly Gln Asn Asp Val Phe Asp Phe Thr Gln 
225                 230                 235                 240 


Pro Ala Gly Val Ser Gly Met Ala Phe Pro Arg Pro Lys Arg Pro Ala 
                245                 250                 255     


Pro Ala Gln Glu Ala Ala Thr Glu Gly Pro Ser Ala Ala Ser Gly Val 
            260                 265                 270         


Pro Gln Thr Gly Pro Gly Arg Glu Val Ala Ala Thr Arg Pro Lys Thr 
        275                 280                 285             


Thr Lys Ser Gly Lys Ala Leu Ala Lys Thr Arg Trp Val Glu Pro Gln 
    290                 295                 300                 


Asn Val Val Ala Ala Ala Ala Ala Lys Ala Lys Met Ala Thr Ser Ile 
305                 310                 315                 320 


Pro Glu Pro Glu Gly Ala Ala Ala Ala Thr Ala Gln His Ser Ala Glu 
                325                 330                 335     


Pro Trp Ala Arg Met Gly Gly Lys Arg Thr Lys Lys Ser Lys His Leu 
            340                 345                 350         


Asp Asp Glu Tyr Glu Ser Ser Glu Glu Glu Arg Glu Thr Pro Ala Val 
        355                 360                 365             


Pro Pro Thr Trp Arg Ala Ser Gln Pro Ser Leu Thr Val Arg Ala Gln 
    370                 375                 380                 


Leu Ala Pro Arg Pro Pro Met Ala Pro Arg Ser Gln Ile Pro Ser Arg 
385                 390                 395                 400 


His Val Leu Cys Leu Pro Pro Arg Asn Val Thr Leu Leu Gln Glu Arg 
                405                 410                 415     


Ala Asn Lys Leu Val Lys Tyr Leu Met Ile Lys Asp Tyr Lys Lys Ile 
            420                 425                 430         


Pro Ile Lys Arg Ala Asp Met Leu Lys Asp Val Ile Arg Glu Tyr Asp 
        435                 440                 445             


Glu His Phe Pro Glu Ile Ile Glu Arg Ala Thr Tyr Thr Leu Glu Lys 
    450                 455                 460                 


Lys Phe Gly Ile His Leu Lys Glu Ile Asp Lys Glu Glu His Leu Tyr 
465                 470                 475                 480 


Ile Leu Val Cys Thr Arg Asp Ser Ser Ala Arg Leu Leu Gly Lys Thr 
                485                 490                 495     


Lys Asp Thr Pro Arg Leu Ser Leu Leu Leu Val Ile Leu Gly Val Ile 
            500                 505                 510         


Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp Glu Ala Leu 
        515                 520                 525             


Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Phe Leu Gly Asp 
    530                 535                 540                 


Leu Arg Lys Leu Ile Thr Asp Asp Phe Val Lys Gln Lys Tyr Leu Glu 
545                 550                 555                 560 


Tyr Lys Lys Ile Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp 
                565                 570                 575     


Gly Leu Arg Ala Arg His Glu Thr Ser Lys Met Arg Val Leu Arg Phe 
            580                 585                 590         


Ile Ala Gln Asn Gln Asn Arg Asp Pro Arg Glu Trp Lys Ala His Phe 
        595                 600                 605             


Leu Glu Ala Val Asp Asp Ala Phe Lys Thr Met Asp Val Asp Met Ala 
    610                 615                 620                 


Glu Glu His Ala Arg Ala Gln Met Arg Ala Gln Met Asn Ile Gly Asp 
625                 630                 635                 640 


Glu Ala Leu Ile Gly Arg Trp Ser Trp Asp Asp Ile Gln Val Glu Leu 
                645                 650                 655     


Leu Thr Trp Asp Glu Asp Gly Asp Phe Gly Asp Ala Trp Ala Arg Ile 
            660                 665                 670         


Pro Phe Ala Phe Trp Ala Arg Tyr His Gln Tyr Ile Leu Asn Ser Asn 
        675                 680                 685             


Arg Ala Asn Arg Arg Ala Thr Trp Arg Ala Gly Val Ser Ser Gly Thr 
    690                 695                 700                 


Asn Gly Gly Ala Ser Thr Ser Val Leu Asp Gly Pro Ser Thr Ser Ser 
705                 710                 715                 720 


Thr Ile Arg Thr Arg Asn Ala Ala Arg Ala Gly Ala Ser Phe Phe Ser 
                725                 730                 735     


Trp Ile Gln His Arg 
            740     


<210>  2380
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-D4__Homo_sapiens__AAH63838

<400>  2380
auggcugagg gaagcuucag cgugcaaucg gaaagcuaca guguugaaga cauggaugag       60

gguagcgacg aagucgggga ggaagagaug guugaaggca acgacuauga agaauucggu      120

gcguuuggug gcuauggcac ccucaccagc uuugacaucc auauccucag agccuucgga      180

agcuuggguc caggccuucg caucuuaucg aaugagcccu gggaacugga aaacccugug      240

cuggcccaga cccuggugga ggcauugcag cuggauccgg aaacacuugc caaugagacg      300

gccgcccgug cugccaacgu agcccgcgcc gccgccucca accgugcggc ucgggccgcu      360

gccgccgcug cccguaccgc cuucagucag guggucgcua gccaccgggu ggccacgccg      420

caggucucag gagaggauac ccagcccacg accuacgccg ccgaggcuca ggggcccacc      480

ccugagccac cccuugcuuc uccgcagacc ucccagaugu uagucaccag uaagauggcu      540

gcccccgagg cuccggcaac cuccgcacag ucccagacag gcuccccggc ccaggaggcu      600

gcuacugagg gcccuaguag cgccugugcu uucucucagg cuccgugugc cagggaggug      660

gacgccaacc ggcccagcac agccuuccug ggccagaaug augucuucga uuucacucag      720

ccggcaggug ucaguggcau ggccuucccg cgccccaaga gaccugcccc agcccaagag      780

gcugccacag agggccccag ugcugccucu ggugugcccc agacgggacc uggcagggag      840

guggcagcca cccggcccaa gaccaccaag ucggggaagg cgcuggccaa gacucggugg      900

guggagccuc agaauguugu ggcagcagcu gcugccaagg ccaagauggc cacgagcauc      960

ccugagccgg agggugcagc ugcugccacu gcucagcaca gugcugagcc cugggccagg     1020

augggaggca agaggaccaa gaaguccaag caccuggaug augaguauga gagcagcgag     1080

gaggagagag agacucccgc ggucccaccc accuggagag caucacagcc cucauugacg     1140

gugcgggcuc aguuggcccc ucggcccccg auggccccga ggucccagau acccucaagg     1200

cacguacugu gccugccccc ccgcaacgug acccuucugc aggagagggc aaauaaguug     1260

gugaaauacc ugaugauuaa ggacuacaag aagaucccca ucaagcgcgc agacaugcug     1320

aaggauguca ucagagaaua ugaugaacau uucccugaga ucauugaacg agcaacguac     1380

acccuggaaa agaaguuugg gauccaccug aaggagaucg acaaggaaga acaccuguau     1440

auucuugucu gcacacggga cuccucagcu cgccuccuug gaaaaaccaa ggacacuccc     1500

aggcugaguc uccucuuggu gauucugggc gucaucuuca ugaauggcaa ccgugccagc     1560

gaggcugucc ucugggaggc acuacgcaag augggacugc gcccuggggu gaggcaccca     1620

uuccucggcg aucugaggaa gcucaucaca gaugacuuug ugaagcagaa guaccuggaa     1680

uacaagaaga uccccaacag caacccaccu gaguaugaau uccucugggg ccugcgagcc     1740

cgccaugaga ccagcaagau gaggguccug agauucaucg cccagaauca gaaccgagac     1800

ccccgggaau ggaaggcuca uuucuuggag gcuguggaug augcuuucaa gacaauggau     1860

guggauaugg ccgaggaaca ugccagggcc cagaugaggg cccagaugaa uaucggggau     1920

gaagcgcuga uuggacggug gagcugggau gacauacaag ucgagcuccu gaccugggau     1980

gaggacggag auuuuggcga ugccugggcc aggauccccu uugcuuucug ggccagauac     2040

caucaguaca uucugaauag caaccgugcc aacaggaggg ccacguggag agcuggcguc     2100

agcaguggca ccaauggagg ggccagcacc agcguccuag auggccccag caccagcucc     2160

accauccgga ccagaaaugc ugccagagcu ggcgccagcu ucuucuccug gauccagcac     2220

cguuga                                                                2226


<210>  2381
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-D4__Homo_sapiens__AAH63838

<400>  2381
auggccgagg gcagcuucuc cgugcagagc gaguccuaca gcgucgagga cauggacgag       60

ggguccgacg aggugggcga ggaggagaug guggagggga acgacuacga ggaguucggc      120

gccuucgggg gcuacggcac ccugaccagc uucgacaucc acauccuccg cgcguucggg      180

ucccugggcc ccgggcugcg gauccucagc aacgagccgu gggagcugga gaaccccguc      240

cuggcccaga cgcucgugga ggcccugcag cuggaccccg agacccucgc caacgagacc      300

gccgcgcgcg ccgccaacgu ggcccgggcg gccgccucca accgcgccgc ccgggcggcc      360

gccgccgccg cgcgcaccgc cuucagccag gucguggccu cccaccgggu ggccacgccc      420

caggucagcg gcgaggacac ccagccgacc accuacgccg cggaggccca ggggcccacg      480

cccgagcccc cgcuggccag cccccagacc agccagaugc uggugaccuc caagauggcc      540

gcccccgagg cgcccgccac cagcgcccag ucccagacgg gcagcccggc ccaggaggcg      600

gccaccgagg gccccuccag cgccugcgcc uucagccagg cccccugcgc gcgcgaggug      660

gacgccaacc ggcccuccac cgccuuccuc gggcagaacg acgucuucga cuucacccag      720

ccggccggcg ugagcgggau ggccuucccc cgccccaagc ggcccgcgcc ggcccaggag      780

gccgccacgg agggccccuc cgccgcgagc ggcgugcccc agaccgggcc cggccgcgag      840

gucgccgcca cccggccgaa gaccacgaag uccgggaagg cccuggcgaa gacccgcugg      900

guggagcccc agaacguggu cgccgccgcc gccgcgaagg ccaagauggc caccagcauc      960

cccgagcccg agggcgccgc cgcggccacc gcccagcacu ccgccgagcc gugggcccgg     1020

augggcggga agcgcacgaa gaaguccaag caccuggacg acgaguacga guccagcgag     1080

gaggagcggg agacccccgc ggugcccccg accuggcgcg ccucccagcc cagccucacc     1140

gugcgggccc agcuggcccc gcgcccgccc auggcgcccc ggucccagau ccccagccgc     1200

cacguccugu gccucccgcc ccgcaacgug acgcugcugc aggagcgggc caacaagcuc     1260

gugaaguacc ugaugaucaa ggacuacaag aagaucccca ucaagcgcgc cgacaugcug     1320

aaggacguca uccgggagua cgacgagcac uuccccgaga ucaucgagcg cgccaccuac     1380

acccucgaga agaaguucgg cauccaccug aaggagaucg acaaggagga gcaccuguac     1440

auccucgugu gcacccggga cuccagcgcc cgccugcugg ggaagacgaa ggacacgccc     1500

cggcucuccc ugcugcucgu cauccugggc gugaucuuca ugaacgggaa ccgcgcgagc     1560

gaggccgugc ugugggaggc ccuccggaag augggccugc gccccggggu ccggcacccc     1620

uuccugggcg accuccgcaa gcugaucacc gacgacuucg ugaagcagaa guaccuggag     1680

uacaagaaga uccccaacuc caacccgccc gaguacgagu uccucugggg ccugcgggcc     1740

cgccacgaga ccagcaagau gcgggugcug cgcuucaucg cccagaacca gaaccgggac     1800

ccccgcgagu ggaaggcgca cuuccucgag gccgucgacg acgccuucaa gaccauggac     1860

guggacaugg ccgaggagca cgcccgggcg cagaugcgcg cccagaugaa caucggggac     1920

gaggcccuga ucggccgcug gagcugggac gacauccagg uggagcugcu caccugggac     1980

gaggacgggg acuucggcga cgccugggcc cggauccccu ucgcguucug ggcccgcuac     2040

caccaguaca uccugaacuc caaccgggcc aaccgccggg ccaccuggcg cgcggggguc     2100

agcuccggca ccaacggcgg ggccagcacc uccgugcugg acggccccag cacguccagc     2160

accauccgga cccgcaacgc cgcccgggcc ggggcguccu ucuucagcug gauccagcac     2220

cgcuga                                                                2226


<210>  2382
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-D4__Homo_sapiens__AAH63838

<400>  2382
auggccgagg gcuccuucuc cguccagucc gaguccuacu ccgucgagga cauggacgag       60

ggcuccgacg aggucggcga ggaggagaug gucgagggca acgacuacga ggaguucggc      120

gccuucggcg gcuacggcac ccucaccucc uucgacaucc acauccuccg cgccuucggc      180

ucccucggcc ccggccuccg cauccucucc aacgagcccu gggagcucga gaaccccguc      240

cucgcccaga cccucgucga ggcccuccag cucgaccccg agacccucgc caacgagacc      300

gccgcccgcg ccgccaacgu cgcccgcgcc gccgccucca accgcgccgc ccgcgccgcc      360

gccgccgccg cccgcaccgc cuucucccag gucgucgccu cccaccgcgu cgccaccccc      420

caggucuccg gcgaggacac ccagcccacc accuacgccg ccgaggccca gggccccacc      480

cccgagcccc cccucgccuc cccccagacc ucccagaugc ucgucaccuc caagauggcc      540

gcccccgagg cccccgccac cuccgcccag ucccagaccg gcucccccgc ccaggaggcc      600

gccaccgagg gccccuccuc cgccugcgcc uucucccagg cccccugcgc ccgcgagguc      660

gacgccaacc gccccuccac cgccuuccuc ggccagaacg acgucuucga cuucacccag      720

cccgccggcg ucuccggcau ggccuucccc cgccccaagc gccccgcccc cgcccaggag      780

gccgccaccg agggccccuc cgccgccucc ggcguccccc agaccggccc cggccgcgag      840

gucgccgcca cccgccccaa gaccaccaag uccggcaagg cccucgccaa gacccgcugg      900

gucgagcccc agaacgucgu cgccgccgcc gccgccaagg ccaagauggc caccuccauc      960

cccgagcccg agggcgccgc cgccgccacc gcccagcacu ccgccgagcc cugggcccgc     1020

augggcggca agcgcaccaa gaaguccaag caccucgacg acgaguacga guccuccgag     1080

gaggagcgcg agacccccgc cguccccccc accuggcgcg ccucccagcc cucccucacc     1140

guccgcgccc agcucgcccc ccgccccccc auggcccccc gcucccagau ccccucccgc     1200

cacguccucu gccucccccc ccgcaacguc acccuccucc aggagcgcgc caacaagcuc     1260

gucaaguacc ucaugaucaa ggacuacaag aagaucccca ucaagcgcgc cgacaugcuc     1320

aaggacguca uccgcgagua cgacgagcac uuccccgaga ucaucgagcg cgccaccuac     1380

acccucgaga agaaguucgg cauccaccuc aaggagaucg acaaggagga gcaccucuac     1440

auccucgucu gcacccgcga cuccuccgcc cgccuccucg gcaagaccaa ggacaccccc     1500

cgccucuccc uccuccucgu cauccucggc gucaucuuca ugaacggcaa ccgcgccucc     1560

gaggccgucc ucugggaggc ccuccgcaag augggccucc gccccggcgu ccgccacccc     1620

uuccucggcg accuccgcaa gcucaucacc gacgacuucg ucaagcagaa guaccucgag     1680

uacaagaaga uccccaacuc caaccccccc gaguacgagu uccucugggg ccuccgcgcc     1740

cgccacgaga ccuccaagau gcgcguccuc cgcuucaucg cccagaacca gaaccgcgac     1800

ccccgcgagu ggaaggccca cuuccucgag gccgucgacg acgccuucaa gaccauggac     1860

gucgacaugg ccgaggagca cgcccgcgcc cagaugcgcg cccagaugaa caucggcgac     1920

gaggcccuca ucggccgcug guccugggac gacauccagg ucgagcuccu caccugggac     1980

gaggacggcg acuucggcga cgccugggcc cgcauccccu ucgccuucug ggcccgcuac     2040

caccaguaca uccucaacuc caaccgcgcc aaccgccgcg ccaccuggcg cgccggcguc     2100

uccuccggca ccaacggcgg cgccuccacc uccguccucg acggccccuc caccuccucc     2160

accauccgca cccgcaacgc cgcccgcgcc ggcgccuccu ucuucuccug gauccagcac     2220

cgcuga                                                                2226


<210>  2383
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-D4__Homo_sapiens__AAH63838

<400>  2383
auggccgagg gcagcuucuc cgugcagucu gaaucauaca gugucgagga cauggaugaa       60

gggagcgacg agguuggaga agaggagaug guggaaggua acgauuauga ggaauuuggc      120

gcuuucgggg gauacggcac ccugacaucc uuugacaucc acauucucag agcauucggu      180

ucucuugggc ccggacugag gauauugucg aaugagccuu gggaguuaga aaacccagua      240

cuggcccaaa cucuagugga ggcgcuccag cuggauccgg aaacgcuugc uaaugagacc      300

gccgcacggg ccgcuaacgu cgcacgcgcc gcugccucaa aucgagcggc acgugccgcu      360

gccgcagcug ccagaacagc guuuagccag gugguugcca gucauagggu ggcaacuccc      420

caggucuccg gcgaagacac ccaaccuaca accuaugcug ccgaggcuca gggcccaacu      480

cccgagccuc cacuggccuc uccccagaca agccagaugu uggugaccuc caagauggca      540

gccccugaag cuccagcgac gucagcacaa agucagacug ggagcccggc ccaggaggcu      600

gccaccgaag gacccucuuc cgcaugcgcc uucucacagg cuccuugugc ccgggaggua      660

gaugcaaacc gcccaagcac agcguuucuc ggucaaaaug acguuuucga uuuuacucag      720

cccgcuggcg ugagugggau ggccuucccu agaccaaaaa ggcccgcacc ggcccaggaa      780

gcugccaccg agggaccuuc ugcagcuucc ggcguccccc aaacaggucc agggcgggag      840

guggccgcga cccgcccuaa gacgacuaaa agcggaaagg cccuggcuaa aacacgaugg      900

guggaacccc agaacgucgu ugcagccgcu gccgcaaagg cgaagauggc caccucgauc      960

ccagagcccg aaggcgcugc cgcagcuacu gcccagcacu cugcagagcc uugggccaga     1020

augggcggga aaaggacaaa gaaauccaag caucuggacg augaauacga gucaagugag     1080

gaggaacggg aaaccccagc ugugccgccc acguggcgug cgagccagcc uucccucacc     1140

guacgcgccc aauuagcacc aagacccccu auggcuccaa ggucucagau ucccagccgg     1200

cacgugcugu gccuuccgcc ucgaaauguc acauugcugc aggagcgcgc caacaagcua     1260

gugaaauauc ucaugaucaa ggacuacaaa aagauuccaa ucaaaagagc cgauaugcug     1320

aaggacguua uaagggagua ugacgaacau uuucccgaga ucauugaacg ggcuacuuac     1380

acccuugaga aaaaguucgg aauccaccug aaagaaauug auaaggagga gcacuuguac     1440

auccucgugu guacacgcga cucaagugca agacuguuag guaagacuaa agauaccccu     1500

aggcuguccc uccuucuggu cauauugggc gugauuuuua ugaaugggaa ccgugccagc     1560

gaagcgguac uaugggaggc ucugcggaag augggacucc gacccggcgu uagacaucca     1620

uuccugggug accuuaggaa acugaucaca gaugacuucg ugaagcagaa auauuuggaa     1680

uacaagaaga uuccuaauuc uaauccccca gaguaugaau uucucugggg gcugcgcgcc     1740

cggcacgaga ccucaaaaau gagagucuua agguucaucg cacaaaacca gaaccgcgau     1800

ccgcgagagu ggaaggccca uuuucuggaa gcuguggacg augcauucaa aacuauggac     1860

gucgauaugg ccgaggaaca cgcgcgggcu cagaugcgug cccagaugaa caucggcgac     1920

gaggcacuaa uuggaagaug gaguugggac gauauacaag uggaacuccu gacgugggac     1980

gaggauggcg acuuugggga ugccugggcu aggaucccuu ucgccuuuug ggcacgcuac     2040

caccaguaua uucuuaauag caaccgggcu aauagaaggg ccacauggcg agcgggaguu     2100

uccucuggua ccaacggcgg ggccucgacu agcguguugg acggacccuc caccucaagu     2160

acaauccgca cccggaaugc agcuagagcc ggcgcuucuu ucuuuagcug gauacagcau     2220

agguga                                                                2226


<210>  2384
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-D4__Homo_sapiens__AAH63838

<400>  2384
auggccgagg gcagcuucag cgugcagagc gagagcuaca gcguggagga cauggacgag       60

ggcagcgacg aggugggcga ggaggagaug guggagggca acgacuacga ggaguucggc      120

gccuucggcg gcuacggcac ccugaccagc uucgacaucc acauccugag agccuucggc      180

agccugggcc ccggccugag aauccugagc aacgagcccu gggagcugga gaaccccgug      240

cuggcccaga cccuggugga ggcccugcag cuggaccccg agacccuggc caacgagacc      300

gccgccagag ccgccaacgu ggccagagcc gccgccagca acagagccgc cagagccgcc      360

gccgccgccg ccagaaccgc cuucagccag gugguggcca gccacagagu ggccaccccc      420

caggugagcg gcgaggacac ccagcccacc accuacgccg ccgaggccca gggccccacc      480

cccgagcccc cccuggccag cccccagacc agccagaugc uggugaccag caagauggcc      540

gcccccgagg cccccgccac cagcgcccag agccagaccg gcagccccgc ccaggaggcc      600

gccaccgagg gccccagcag cgccugcgcc uucagccagg cccccugcgc cagagaggug      660

gacgccaaca gacccagcac cgccuuccug ggccagaacg acguguucga cuucacccag      720

cccgccggcg ugagcggcau ggccuucccc agacccaaga gacccgcccc cgcccaggag      780

gccgccaccg agggccccag cgccgccagc ggcgugcccc agaccggccc cggcagagag      840

guggccgcca ccagacccaa gaccaccaag agcggcaagg cccuggccaa gaccagaugg      900

guggagcccc agaacguggu ggccgccgcc gccgccaagg ccaagauggc caccagcauc      960

cccgagcccg agggcgccgc cgccgccacc gcccagcaca gcgccgagcc cugggccaga     1020

augggcggca agagaaccaa gaagagcaag caccuggacg acgaguacga gagcagcgag     1080

gaggagagag agacccccgc cgugcccccc accuggagag ccagccagcc cagccugacc     1140

gugagagccc agcuggcccc cagacccccc auggccccca gaagccagau ccccagcaga     1200

cacgugcugu gccugccccc cagaaacgug acccugcugc aggagagagc caacaagcug     1260

gugaaguacc ugaugaucaa ggacuacaag aagaucccca ucaagagagc cgacaugcug     1320

aaggacguga ucagagagua cgacgagcac uuccccgaga ucaucgagag agccaccuac     1380

acccuggaga agaaguucgg cauccaccug aaggagaucg acaaggagga gcaccuguac     1440

auccuggugu gcaccagaga cagcagcgcc agacugcugg gcaagaccaa ggacaccccc     1500

agacugagcc ugcugcuggu gauccugggc gugaucuuca ugaacggcaa cagagccagc     1560

gaggccgugc ugugggaggc ccugagaaag augggccuga gacccggcgu gagacacccc     1620

uuccugggcg accugagaaa gcugaucacc gacgacuucg ugaagcagaa guaccuggag     1680

uacaagaaga uccccaacag caaccccccc gaguacgagu uccugugggg ccugagagcc     1740

agacacgaga ccagcaagau gagagugcug agauucaucg cccagaacca gaacagagac     1800

cccagagagu ggaaggccca cuuccuggag gccguggacg acgccuucaa gaccauggac     1860

guggacaugg ccgaggagca cgccagagcc cagaugagag cccagaugaa caucggcgac     1920

gaggcccuga ucggcagaug gagcugggac gacauccagg uggagcugcu gaccugggac     1980

gaggacggcg acuucggcga cgccugggcc agaauccccu ucgccuucug ggccagauac     2040

caccaguaca uccugaacag caacagagcc aacagaagag ccaccuggag agccggcgug     2100

agcagcggca ccaacggcgg cgccagcacc agcgugcugg acggccccag caccagcagc     2160

accaucagaa ccagaaacgc cgccagagcc ggcgccagcu ucuucagcug gauccagcac     2220

agauga                                                                2226


<210>  2385
<211>  2226
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-D4__Homo_sapiens__AAH63838

<400>  2385
auggccgagg gcagcuucuc cgugcagucu gaaagcuacu ccgucgagga cauggaugaa       60

gggucugacg agguuggaga agaggagaug guggaaggca acgauuauga ggaauuuggg      120

gcuuucggag gcuacgggac ccugacaucc uuugacaucc acauucucag agccuucgga      180

ucccugggcc ccggccuucg gauccugucu aaugagccuu gggagcucga aaacccggug      240

cuggcgcaaa cgcuugucga ggcucugcag cucgaucccg aaacccuggc caaugagaca      300

gccgcucgcg ccgcuaacgu ggccagagcg gccgcuagca aucgggccgc ucgcgccgcg      360

gccgcugccg cuagaaccgc cuuuucccag guuguggcca gccaucgggu cgcuacaccu      420

caggugucug gggaagacac ccaacccaca accuaugcgg ccgaggcuca gggaccuacg      480

cccgagccuc cgcuggccag cccccagacc agccagaugc ucguuacauc uaagauggcc      540

gcuccugaag cccccgcgac cuccgcucaa agccagacag gcucuccugc ccaggaggcc      600

gcuaccgaag ggcccuccag cgccugcgcu uucucccagg ccccgugugc gcgcgaggug      660

gaugccaaca gaccuucuac ggcuuuucug ggacaaaaug acgucuucga uuuuacacag      720

cccgccggcg ugagcgggau ggcuuucccu cggcccaaac gccccgcccc ugcgcaggaa      780

gccgcuaccg agggaccguc cgccgcuagc ggcgugcccc aaacaggccc ugggagagag      840

gucgccgcca cccggcccaa gaccacaaaa ucuggaaagg cucuugcgaa aacgcgcugg      900

guugaaccuc agaacguggu ggccgcugcc gccgcuaagg ccaagauggc gaccuccauu      960

cccgagccgg aaggcgcugc cgccgcuaca gcccagcaca gcgcggagcc uugggcuaga     1020

augggaggga aacggaccaa gaaaucuaag caucuggacg augaauacga gagcuccgag     1080

gaggaacgcg aaacacccgc cgucccuccc accuggagag ccucucagcc uagccucacg     1140

gugcgggcuc aacuggcccc cagaccgccu auggcucccc gcucccagau ccccagccgg     1200

cacguucuuu gccugccucc gagaaaugug acacuccugc aggagcgcgc caacaaacug     1260

gucaaguauc ucaugauuaa ggacuacaaa aagaucccca ucaaacgggc ggauaugcug     1320

aaggacguga uuagagagua ugacgaacau uuuccugaga ucauugaacg cgccaccuac     1380

acccuugaga aaaaguucgg cauccaccug aaagaaauug auaaggagga gcaccucuac     1440

auccugguuu guacacggga cucuuccgcu agacuucugg ggaagaccaa agauacaccc     1500

cgccucagcc ugcugcucgu gauucuggga gucaucuuua ugaauggcaa ccgggccucu     1560

gaagcugugc uuugggaggc ccugagaaag augggccucc gcccuggggu ccggcauccc     1620

uuccugggag accuuagaaa acugaucacg gaugacuucg ugaagcagaa auaucucgaa     1680

uacaagaaga uuccuaauuc caaucccccg gaguaugaau uucugugggg ccugcgggcc     1740

cgccacgaga ccagcaaaau gagaguucuc cgguucaucg cucaaaauca gaacagagau     1800

ccucgcgagu ggaaggcgca uuuucuggaa gccguggacg augcuuucaa aacaauggac     1860

gucgauaugg ccgaggaaca cgcccgggcu cagaugagag cccagaugaa cauuggggac     1920

gaggcgcuua ucggacgcug guccugggac gauauucaag uggaacugcu caccugggac     1980

gaggauggcg acuuugggga ugcuugggcc agaauccccu ucgccuuuug ggcucgguac     2040

caccaguaua uccugaacuc uaaccgcgcc aauagacggg cgacauggcg cgcuggcguu     2100

agcuccggaa ccaacggcgg ggccucuacg agcgugcugg acggaccuuc caccagcucu     2160

acaauuagaa cccggaaugc cgcucgcgcc ggcgcuuccu ucuuuagcug gauccagcau     2220

agauga                                                                2226


<210>  2386
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-_E1__Homo_sapiens__Q6IAI7

<400>  2386

Met Pro Pro Val Pro Gly Val Pro Phe Arg Asn Val Asp Asn Asp Ser 
1               5                   10                  15      


Pro Thr Ser Val Glu Leu Glu Asp Trp Val Asp Ala Gln His Pro Thr 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Ala Ser Ser Ala Ser Ser Thr Leu Tyr Leu 
        35                  40                  45              


Val Phe Ser Pro Ser Ser Phe Ser Thr Ser Ser Ser Leu Ile Leu Gly 
    50                  55                  60                  


Gly Pro Glu Glu Glu Glu Val Pro Ser Gly Val Ile Pro Asn Leu Thr 
65                  70                  75                  80  


Glu Ser Ile Pro Ser Ser Pro Pro Gln Gly Pro Pro Gln Gly Pro Ser 
                85                  90                  95      


Gln Ser Pro Leu Ser Ser Cys Cys Ser Ser Phe Ser Trp Ser Ser Phe 
            100                 105                 110         


Ser Glu Glu Ser Ser Ser Gln Lys Gly Glu Asp Thr Gly Thr Cys Gln 
        115                 120                 125             


Gly Leu Pro Asp Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys 
    130                 135                 140                 


Val Ala Glu Leu Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu 
145                 150                 155                 160 


Pro Val Thr Glu Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp 
                165                 170                 175     


Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
            180                 185                 190         


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
        195                 200                 205             


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
    210                 215                 220                 


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
225                 230                 235                 240 


Gly Asn Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Val 
                245                 250                 255     


Gly Val Tyr Ala Gly Arg Glu His Phe Val Tyr Gly Glu Pro Arg Glu 
            260                 265                 270         


Leu Leu Thr Lys Val Trp Val Gln Gly His Tyr Leu Glu Tyr Arg Glu 
        275                 280                 285             


Val Pro His Ser Ser Pro Pro Tyr Tyr Glu Phe Leu Trp Gly Pro Arg 
    290                 295                 300                 


Ala His Ser Glu Ser Ile Lys Lys Lys Val Leu Glu Phe Leu Ala Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Val Pro Ser Ser Phe Pro Ser Trp Tyr Lys Asp Ala 
                325                 330                 335     


Leu Lys Asp Val Glu Glu Arg Val Gln Ala Thr Ile Asp Thr Ala Asp 
            340                 345                 350         


Asp Ala Thr Val Met Ala Ser Glu Ser Leu Ser Val Met Ser Ser Asn 
        355                 360                 365             


Val Ser Phe Ser Asp 
    370             


<210>  2387
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-_E1__Homo_sapiens__CAG33449

<400>  2387
augccucccg uuccaggcgu uccauuccgc aacguugaca acgacucccc gaccucaguu       60

gaguuagaag acuggguaga ugcacagcau cccacagaug aggaagagga ggaagccucc      120

uccgccucuu ccacuuugua cuuaguauuu ucccccucuu cuuucuccac auccucuucu      180

cugauucuug gugguccuga ggaggaggag gugcccucug gugugauacc aaaucuuacc      240

gagagcauuc ccaguagucc uccacagggu ccuccacagg guccuuccca gaguccucug      300

agcuccugcu gcuccucuuu uucauggagc ucauucagug aggaguccag cagccagaaa      360

ggggaggaua caggcaccug ucagggccug ccagacagug aguccucuuu cacauauaca      420

cuagaugaaa agguggccga guuaguggag uuccugcucc ucaaauacga agcagaggag      480

ccuguaacag aggcagagau gcugaugauu gucaucaagu acaaagauua cuuuccugug      540

auacucaaga gagcccguga guucauggag cuucuuuuug gccuugcccu gauagaagug      600

ggcccugacc acuucugugu guuugcaaac acaguaggcc ucaccgauga ggguagugau      660

gaugagggca ugcccgagaa cagccuccug auuauuauuc ugagugugau cuucauaaag      720

ggcaacugug ccucugagga ggucaucugg gaagugcuga augcaguagg gguauaugcu      780

gggagggagc acuucgucua uggggagccu agggagcucc ucacuaaagu uugggugcag      840

ggacauuacc uggaguaucg ggaggugccc cacaguucuc cuccauauua ugaauuccug      900

ugggguccaa gagcccauuc agaaagcauc aagaagaaag uacuagaguu uuuagccaag      960

cugaacaaca cuguuccuag uuccuuucca uccugguaca aggaugcuuu gaaagaugug     1020

gaagagagag uccaggccac aauugauacc gcagaugaug ccacugucau ggccagugaa     1080

agccucagug ucauguccag caacgucucc uuuucugauu aa                        1122


<210>  2388
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-_E1__Homo_sapiens__CAG33449

<400>  2388
augccgcccg ugcccggcgu ccccuuccgc aacguggaca acgacagccc caccuccgug       60

gagcuggagg acugggucga cgcccagcac cccaccgacg aggaggagga ggaggccagc      120

uccgcgagcu ccacgcucua ccugguguuc agccccucca gcuucuccac cagcuccagc      180

cugauccucg ggggccccga ggaggaggag gugcccuccg gggucauccc gaaccugacc      240

gagagcaucc ccuccagccc gccccagggc ccgccccagg ggcccuccca gagcccccug      300

uccagcugcu gcagcuccuu cagcuggucc agcuucuccg aggagagcuc cagccagaag      360

ggcgaggaca ccggcacgug ccaggggcuc ccggacuccg agagcuccuu caccuacacc      420

cuggacgaga agguggccga gcugguggag uuccuccugc ugaaguacga ggccgaggag      480

cccgucaccg aggccgagau gcucaugauc gugaucaagu acaaggacua cuuccccgug      540

auccugaagc gggcccgcga guucauggag cuccuguucg gccuggcgcu gaucgagguc      600

gggcccgacc acuucugcgu guucgccaac acggugggcc ucaccgacga ggggagcgac      660

gacgagggca ugccggagaa cucccugcug aucaucaucc ucagcgucau cuucaucaag      720

ggcaacugcg ccuccgagga ggugaucugg gaggugcuga acgccgucgg gguguacgcg      780

ggccgggagc acuucgugua cggggagccc cgcgagcugc ucaccaaggu cugggugcag      840

ggccacuacc uggaguaccg ggaggugccc cacagcuccc cgcccuacua cgaguuccug      900

uggggccccc gcgcccacag cgaguccauc aagaagaagg uccucgaguu ccuggccaag      960

cugaacaaca ccgugcccag cagcuucccc uccugguaca aggacgcccu caaggacguc     1020

gaggagcggg ugcaggccac gaucgacacc gcggacgacg ccaccgugau ggccagcgag     1080

ucccugagcg ucauguccag caacgugucc uucagcgacu ga                        1122


<210>  2389
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-_E1__Homo_sapiens__CAG33449

<400>  2389
augccccccg uccccggcgu ccccuuccgc aacgucgaca acgacucccc caccuccguc       60

gagcucgagg acugggucga cgcccagcac cccaccgacg aggaggagga ggaggccucc      120

uccgccuccu ccacccucua ccucgucuuc ucccccuccu ccuucuccac cuccuccucc      180

cucauccucg gcggccccga ggaggaggag guccccuccg gcgucauccc caaccucacc      240

gaguccaucc ccuccucccc cccccagggc cccccccagg gccccuccca guccccccuc      300

uccuccugcu gcuccuccuu cuccuggucc uccuucuccg aggaguccuc cucccagaag      360

ggcgaggaca ccggcaccug ccagggccuc cccgacuccg aguccuccuu caccuacacc      420

cucgacgaga aggucgccga gcucgucgag uuccuccucc ucaaguacga ggccgaggag      480

cccgucaccg aggccgagau gcucaugauc gucaucaagu acaaggacua cuuccccguc      540

auccucaagc gcgcccgcga guucauggag cuccucuucg gccucgcccu caucgagguc      600

ggccccgacc acuucugcgu cuucgccaac accgucggcc ucaccgacga gggcuccgac      660

gacgagggca ugcccgagaa cucccuccuc aucaucaucc ucuccgucau cuucaucaag      720

ggcaacugcg ccuccgagga ggucaucugg gagguccuca acgccgucgg cgucuacgcc      780

ggccgcgagc acuucgucua cggcgagccc cgcgagcucc ucaccaaggu cuggguccag      840

ggccacuacc ucgaguaccg cgaggucccc cacuccuccc cccccuacua cgaguuccuc      900

uggggccccc gcgcccacuc cgaguccauc aagaagaagg uccucgaguu ccucgccaag      960

cucaacaaca ccguccccuc cuccuucccc uccugguaca aggacgcccu caaggacguc     1020

gaggagcgcg uccaggccac caucgacacc gccgacgacg ccaccgucau ggccuccgag     1080

ucccucuccg ucauguccuc caacgucucc uucuccgacu ga                        1122


<210>  2390
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-_E1__Homo_sapiens__CAG33449

<400>  2390
augcccccug ugccaggcgu cccguucaga aacguugaca augauagccc caccuccgug       60

gagcuggaag acuggguaga ugcccagcac ccuacagacg aggaagagga agaggcuucu      120

ucagcaagua gcacucucua ccuuguguuu uccccaucuu cguucucaac gagcaguucc      180

cugaucuuag ggggacccga ggaagaggaa gucccuucug gugugauucc aaacuugacc      240

gagagcauac ccuccucacc uccacaaggc ccgccccagg ggccuaguca gagcccacug      300

ucuuccugcu guagcucauu uaguuggucu uccuucagcg aggaaucguc uucccagaag      360

ggagaggaua caggcacuug ccaaggucua cccgacucag aaaguagcuu uaccuauaca      420

cucgaugaga aaguugccga acugguggag uuccuucugu ugaaguacga ggcggaagaa      480

ccugucaccg aagcugagau gcucaugauc gugauuaaau auaaggacua cuuuccagua      540

auccugaaaa gggcccggga guucauggag cugcucuuug gguuagcacu gauugagguu      600

ggacccgauc auuucugugu guuugccaau acugucggcc uuacagacga aggcuccgau      660

gacgagggga ugccggaaaa cucuuugcug aucauaaucc uaagcgugau uuucaucaag      720

ggaaauugcg cuucagagga agugauuugg gagguccuca acgcaguugg uguguaugcc      780

ggccgcgagc acuuuguaua cggggaaccu cgagagcugc uuaccaaggu guggguccag      840

ggacauuauc uggaauaccg ugaggugccc cacaguuccc caccuuacua ugaguucuug      900

uggggcccca gagcucauag cgaaucuauc aaaaagaaag uucucgaguu ccuggccaag      960

uuaaauaaca cggugccauc aaguuuuccc agcugguaca aagaugcgcu gaaggacguc     1020

gaagagaggg ugcaggcaac uauagacacc gccgaugacg cuacaguaau ggccuccgaa     1080

ucucucucgg uuaugagcuc caauguguca uucagugauu ga                        1122


<210>  2391
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-_E1__Homo_sapiens__CAG33449

<400>  2391
augccccccg ugcccggcgu gcccuucaga aacguggaca acgacagccc caccagcgug       60

gagcuggagg acugggugga cgcccagcac cccaccgacg aggaggagga ggaggccagc      120

agcgccagca gcacccugua ccugguguuc agccccagca gcuucagcac cagcagcagc      180

cugauccugg gcggccccga ggaggaggag gugcccagcg gcgugauccc caaccugacc      240

gagagcaucc ccagcagccc cccccagggc cccccccagg gccccagcca gagcccccug      300

agcagcugcu gcagcagcuu cagcuggagc agcuucagcg aggagagcag cagccagaag      360

ggcgaggaca ccggcaccug ccagggccug cccgacagcg agagcagcuu caccuacacc      420

cuggacgaga agguggccga gcugguggag uuccugcugc ugaaguacga ggccgaggag      480

cccgugaccg aggccgagau gcugaugauc gugaucaagu acaaggacua cuuccccgug      540

auccugaaga gagccagaga guucauggag cugcuguucg gccuggcccu gaucgaggug      600

ggccccgacc acuucugcgu guucgccaac accgugggcc ugaccgacga gggcagcgac      660

gacgagggca ugcccgagaa cagccugcug aucaucaucc ugagcgugau cuucaucaag      720

ggcaacugcg ccagcgagga ggugaucugg gaggugcuga acgccguggg cguguacgcc      780

ggcagagagc acuucgugua cggcgagccc agagagcugc ugaccaaggu gugggugcag      840

ggccacuacc uggaguacag agaggugccc cacagcagcc cccccuacua cgaguuccug      900

uggggcccca gagcccacag cgagagcauc aagaagaagg ugcuggaguu ccuggccaag      960

cugaacaaca ccgugcccag cagcuucccc agcugguaca aggacgcccu gaaggacgug     1020

gaggagagag ugcaggccac caucgacacc gccgacgacg ccaccgugau ggccagcgag     1080

agccugagcg ugaugagcag caacgugagc uucagcgacu ga                        1122


<210>  2392
<211>  1122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-_E1__Homo_sapiens__CAG33449

<400>  2392
augcccccug ugccgggcgu ccccuucaga aacguugaca augauagccc uaccuccgug       60

gagcuggaag acugggugga ugcccagcac cccacagacg aggaagagga agaggcuucu      120

agcgccuccu cuacgcucua ccuggucuuu agcccuuccu cuuucagcac cuccagcucu      180

cuuauccucg ggggacccga ggaagaggaa gugccuuccg gcguuauucc gaaccugaca      240

gagagcaucc ccucuucccc uccccaaggg ccuccccagg gaccgagcca gucuccucug      300

uccagcugcu guuccucuuu uagcuggucc agcuucucug aggaauccag cucucagaag      360

ggcgaggaua ccgggacaug ccaaggacuu cccgacagcg aauccucuuu uaccuauaca      420

cuggaugaga aaguggcgga acucgucgag uuccugcugc ucaaguacga ggcugaagaa      480

ccugugaccg aagccgagau gcugaugauu guuaucaaau auaaggacua cuuucccgug      540

auucuuaaac gggcccgcga guucauggag cugcucuuug gccuggcucu uaucgagguc      600

ggccccgauc auuucugugu guuugccaau acgguggggc ugaccgacga aggaagcgau      660

gacgagggca ugccugaaaa cucccuccug aucauuaucc ugagcgucau uuucaucaag      720

gggaauugcg cuucugagga aguuauuugg gaggugcuca acgccguggg agucuaugcg      780

ggcagagagc acuuugugua cggggaaccg cgggagcugc uuacaaaggu uugggugcag      840

ggacauuauc uggaauaccg cgaggucccc cacuccagcc cucccuacua ugaguuccuc      900

uggggcccua gagcccauuc ugaauccauc aaaaagaaag ugcuggaguu ccuugcuaag      960

cugaauaaca ccguucccag cuccuuuccg ucuugguaca aagaugcccu caaggacgug     1020

gaggaacggg uccaggcuac aauugacacc gccgaugacg cgacggugau ggccagcgaa     1080

ucccugucug ucaugagcuc caaugugagc uucucugauu ga                        1122


<210>  2393
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-E1_(MAGE1)__Homo_sapiens__Q9HCI5

<400>  2393

Met Ser Leu Val Ser Gln Asn Ser Arg Arg Arg Arg Arg Arg Val Ala 
1               5                   10                  15      


Lys Ala Thr Ala His Asn Ser Ser Trp Gly Glu Met Gln Ala Pro Asn 
            20                  25                  30          


Ala Pro Gly Leu Pro Ala Asp Val Pro Gly Ser Asp Val Pro Gln Gly 
        35                  40                  45              


Pro Ser Asp Ser Gln Ile Leu Gln Gly Leu Cys Ala Ser Glu Gly Pro 
    50                  55                  60                  


Ser Thr Ser Val Leu Pro Thr Ser Ala Glu Gly Pro Ser Thr Phe Val 
65                  70                  75                  80  


Pro Pro Thr Ile Ser Glu Ala Ser Ser Ala Ser Gly Gln Pro Thr Ile 
                85                  90                  95      


Ser Glu Gly Pro Gly Thr Ser Val Leu Pro Thr Pro Ser Glu Gly Leu 
            100                 105                 110         


Ser Thr Ser Gly Pro Pro Thr Ile Ser Lys Gly Leu Cys Thr Ser Val 
        115                 120                 125             


Thr Leu Ala Ala Ser Glu Gly Arg Asn Thr Ser Arg Pro Pro Thr Ser 
    130                 135                 140                 


Ser Glu Glu Pro Ser Thr Ser Val Pro Pro Thr Ala Ser Glu Val Pro 
145                 150                 155                 160 


Ser Thr Ser Leu Pro Pro Thr Pro Gly Glu Gly Thr Ser Thr Ser Val 
                165                 170                 175     


Pro Pro Thr Ala Tyr Glu Gly Pro Ser Thr Ser Val Val Pro Thr Pro 
            180                 185                 190         


Asp Glu Gly Pro Ser Thr Ser Val Leu Pro Thr Pro Gly Glu Gly Pro 
        195                 200                 205             


Gly Thr Ser Val Pro Leu Ala Ala Thr Glu Gly Leu Ser Thr Ser Val 
    210                 215                 220                 


Gln Ala Thr Pro Asp Glu Gly Pro Ser Thr Ser Val Pro Pro Thr Ala 
225                 230                 235                 240 


Thr Glu Gly Leu Ser Thr Pro Val Pro Pro Thr Arg Asp Glu Gly Pro 
                245                 250                 255     


Ser Thr Ser Val Pro Ala Thr Pro Gly Glu Gly Pro Ser Thr Ser Val 
            260                 265                 270         


Leu Pro Ala Ala Ser Asp Gly Gln Ser Ile Ser Leu Val Pro Thr Arg 
        275                 280                 285             


Gly Lys Gly Ser Ser Thr Ser Val Pro Pro Thr Ala Thr Glu Gly Leu 
    290                 295                 300                 


Ser Thr Ser Val Gln Pro Thr Ala Gly Glu Gly Ser Ser Thr Ser Val 
305                 310                 315                 320 


Pro Pro Thr Pro Gly Gly Gly Leu Ser Thr Ser Val Pro Pro Thr Ala 
                325                 330                 335     


Thr Glu Glu Leu Ser Thr Ser Val Pro Pro Thr Pro Gly Glu Gly Pro 
            340                 345                 350         


Ser Thr Ser Val Leu Pro Ile Pro Gly Glu Gly Leu Ser Thr Ser Val 
        355                 360                 365             


Pro Pro Thr Ala Ser Asp Gly Ser Asp Thr Ser Val Pro Pro Thr Pro 
    370                 375                 380                 


Gly Glu Gly Ala Ser Thr Leu Val Gln Pro Thr Ala Pro Asp Gly Pro 
385                 390                 395                 400 


Gly Ser Ser Val Leu Pro Asn Pro Gly Glu Gly Pro Ser Thr Leu Phe 
                405                 410                 415     


Ser Ser Ser Ala Ser Val Asp Arg Asn Pro Ser Lys Cys Ser Leu Val 
            420                 425                 430         


Leu Pro Ser Pro Arg Val Thr Lys Ala Ser Val Asp Ser Asp Ser Glu 
        435                 440                 445             


Gly Pro Lys Gly Ala Glu Gly Pro Ile Glu Phe Glu Val Leu Arg Asp 
    450                 455                 460                 


Cys Glu Ser Pro Asn Ser Ile Ser Ile Met Gly Leu Asn Thr Ser Arg 
465                 470                 475                 480 


Val Ala Ile Thr Leu Lys Pro Gln Asp Pro Met Glu Gln Asn Val Ala 
                485                 490                 495     


Glu Leu Leu Gln Phe Leu Leu Val Lys Asp Gln Ser Lys Tyr Pro Ile 
            500                 505                 510         


Arg Glu Ser Glu Met Arg Glu Tyr Ile Val Lys Glu Tyr Arg Asn Gln 
        515                 520                 525             


Phe Pro Glu Ile Leu Arg Arg Ala Ala Ala His Leu Glu Cys Ile Phe 
    530                 535                 540                 


Arg Phe Glu Leu Arg Glu Leu Asp Pro Glu Ala His Thr Tyr Ile Leu 
545                 550                 555                 560 


Leu Asn Lys Leu Gly Pro Val Pro Phe Glu Gly Leu Glu Glu Ser Pro 
                565                 570                 575     


Asn Gly Pro Lys Met Gly Leu Leu Met Met Ile Leu Gly Gln Ile Phe 
            580                 585                 590         


Leu Asn Gly Asn Gln Ala Lys Glu Ala Glu Ile Trp Glu Met Leu Trp 
        595                 600                 605             


Arg Met Gly Val Gln Arg Glu Arg Arg Leu Ser Ile Phe Gly Asn Pro 
    610                 615                 620                 


Lys Arg Leu Leu Ser Val Glu Phe Val Trp Gln Arg Tyr Leu Asp Tyr 
625                 630                 635                 640 


Arg Pro Val Thr Asp Cys Lys Pro Val Glu Tyr Glu Phe Phe Trp Gly 
                645                 650                 655     


Pro Arg Ser His Leu Glu Thr Thr Lys Met Lys Ile Leu Lys Phe Met 
            660                 665                 670         


Ala Lys Ile Tyr Asn Lys Asp Pro Met Asp Trp Pro Glu Lys Tyr Asn 
        675                 680                 685             


Glu Ala Leu Glu Glu Asp Ala Ala Arg Ala Phe Ala Glu Gly Trp Gln 
    690                 695                 700                 


Ala Leu Pro His Phe Arg Arg Pro Phe Phe Glu Glu Ala Ala Ala Glu 
705                 710                 715                 720 


Val Pro Ser Pro Asp Ser Glu Val Ser Ser Tyr Ser Ser Lys Tyr Ala 
                725                 730                 735     


Pro His Ser Trp Pro Glu Ser Arg Leu Glu Ser Lys Ala Arg Lys Leu 
            740                 745                 750         


Val Gln Leu Phe Leu Leu Met Asp Ser Thr Lys Leu Pro Ile Pro Lys 
        755                 760                 765             


Lys Gly Ile Leu Tyr Tyr Ile Gly Arg Glu Cys Ser Lys Val Phe Pro 
    770                 775                 780                 


Asp Leu Leu Asn Arg Ala Ala Arg Thr Leu Asn His Val Tyr Gly Thr 
785                 790                 795                 800 


Glu Leu Val Val Leu Asp Pro Arg Asn His Ser Tyr Thr Leu Tyr Asn 
                805                 810                 815     


Arg Arg Glu Met Glu Glu Thr Glu Glu Ile Val Asp Ser Pro Asn Arg 
            820                 825                 830         


Pro Gly Asn Asn Phe Leu Met Gln Val Leu Ser Phe Ile Phe Ile Met 
        835                 840                 845             


Gly Asn His Ala Arg Glu Ser Ala Val Trp Ala Phe Leu Arg Gly Leu 
    850                 855                 860                 


Gly Val Gln Ala Gly Arg Lys His Val Ile Thr Cys Arg Tyr Leu Ser 
865                 870                 875                 880 


Gln Arg Tyr Ile Asp Ser Leu Arg Val Pro Asp Ser Asp Pro Val Gln 
                885                 890                 895     


Tyr Glu Phe Val Trp Gly Pro Arg Ala Arg Leu Glu Thr Ser Lys Met 
            900                 905                 910         


Lys Ala Leu Arg Tyr Val Ala Arg Ile His Arg Lys Glu Pro Gln Asp 
        915                 920                 925             


Trp Pro Gln Gln Tyr Arg Glu Ala Met Glu Asp Glu Ala Asn Arg Ala 
    930                 935                 940                 


Asp Val Gly His Arg Gln Ile Phe Val His Asn Phe Arg 
945                 950                 955         


<210>  2394
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2394
augucucugg uaagccagaa uucgcgccgc cgccgccgcc gcguugcaaa ggcuacugcg       60

cacaacagca gcuggggcga aaugcaggcc ccuaaugccc ccggucuccc cgcugaugug      120

ccaggcucag acguccccca gggucccagc gauucccaga uccuccaggg ccucugcgcc      180

ucugagggcc caagcaccuc cguucugccc accuccgcug agggcccaag caccuuugug      240

ccgcccacca ucucugaggc cucaagcgcc uccgggcagc ccaccaucuc ugagggaccu      300

ggcaccuccg ugcugcccac ccccagugag ggccuaagca ccuccgggcc ucccaccauc      360

ucuaaggggc ugugcaccuc ugugacgcuu gccgccucug agggccggaa caccuccagg      420

ccgcccacuu ccucugagga accuagcacc uccgugccgc ccaccgccuc ugagguaccg      480

agcaccuccc ugccgcccac cccuggugag ggaacgagca ccuccgugcc gcccacagcc      540

uaugagggac caagcaccuc cguggugccc accccugaug agggaccaag caccuccgug      600

cugccuacac cuggugaggg accaggcacc uccgugccgc ucgccgccac ugagggccug      660

agcaccuccg ugcaggccac uccugaugag ggaccgagca ccuccgugcc gcccaccgcc      720

acugagggcc uaagcacccc cgugccaccc acccgugaug agggaccgag caccuccgug      780

ccggccacuc cuggugaggg accgagcacc uccgugcugc ccgccgccuc ugacggacaa      840

agcaucuccu uggugcccac ccgcgguaag ggaucaagca ccuccgugcc ccccaccgcc      900

accgagggcc ugagcaccuc cgugcagccc acugcuggug agggaucgag caccuccgug      960

ccgcccaccc cugguggggg acugagcacc uccgugccgc ccaccgccac ugaggaguug     1020

agcaccuccg ugccgcccac ucccggugag ggaccaagca cuuccguacu gccaaucccc     1080

ggugagggac ugagcaccuc ugugccgccc accgccucug auggaucgga caccuccgug     1140

ccgcccacuc cuggugaggg cgcaagcacc uuagugcagc ccaccgcccc ugacggaccg     1200

ggaagcuccg ugcugccuaa cccuggugag ggcccgagca cauuguuuag cucuagugcu     1260

ucuguggacc ggaaccccuc caaguguucc cuuguuuugc caagcccuag gguaaccaag     1320

gccuccgugg acucagauuc ugaggguccu aagggugcag aaggcccuau agaauucgag     1380

guccugagag acugugagag ccccaacucc auuaguauua ugggccucaa uacuucccgg     1440

guugcaauua cccugaagcc ccaagacccu auggaacaga acguagcuga gcuguugcag     1500

uuccugcugg ugaaggauca gagcaaguac ccuauccggg agucugaaau gcgggaauau     1560

auuguuaaag aauaucgcaa ccaguuuccu gagauacuca ggcgagcagc agcccaccug     1620

gagugcauuu uuagguuuga auugagagaa cuugacccug aggcacacac cuacauucug     1680

uuaaacaaac ugggaccugu gcccuuugaa ggguuagaag agagcccaaa ugggccaaag     1740

augggccucc ugaugaugau ucuaggccaa auauuccuga auggcaacca agccaaggag     1800

gcugagauuu gggaaaugcu cuggaggaug ggggugcagc gggaaaggag gcuuuccauu     1860

uuugggaacc caaagagacu ucugucugug gaguuuguau ggcagcguua cuuagacuac     1920

aggccaguaa cugacuguaa accaguggag uaugaguuuu ucuggggccc aagaucccac     1980

cuagaaacca ccaagaugaa aauucugaag uucauggcga aaauauauaa caaagauccu     2040

auggauuggc cagagaaaua caacgaagcu cuggaagaag augcugccag agccuuugcu     2100

gaggguuggc aggcucuccc ucacuuuagg aggcccuuuu uugaggaagc ugcugcagag     2160

guaccauccc cugauucaga gguuuccagc uauuccucaa aauaugcccc acauucaugg     2220

ccugagucaa gauuggagag caaggcaagg aagcuggugc aguuauuucu gcuuauggau     2280

ucaacuaagc ugccuauacc aaagaaagga auucuguacu acauuggccg agagugcagc     2340

aaaguguucc cugaccuccu gaaucgugcu gcccgcaccc ugaaccaugu cuaugggaca     2400

gaacuagugg uacuugaucc caggaaucac uccuauacuc uguacaaccg aagggagaug     2460

gaagaaacug aggagaucgu agacagucca aacaggccug gcaacaacuu uuugaugcag     2520

guccuaagcu ucaucuuuau uaugggcaac caugccaggg agucugcagu cugggccuuu     2580

cugcggggcu uagggguuca agcugggaga aagcauguga uuaccugcag auacuugagu     2640

cagcgcuaua uagacaguuu acggguuccu gacagugauc cagugcaaua ugaguuugua     2700

ugggguccua gagcccguuu ggaaaccucu aagaugaaag ccuugcgaua uguggccaga     2760

auccacagaa aggaaccaca ggacuggcca cagcaguaca gggaggcaau ggaagaugag     2820

gccaauagag cugauguugg gcacaggcaa aucuuuguuc acaacuucag guag           2874


<210>  2395
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2395
augagccugg ugucccagaa cagccgccgg cgccggcgcc gggucgccaa ggccaccgcg       60

cacaacucca gcuggggcga gaugcaggcc cccaacgccc cggggcuccc cgccgacgug      120

cccggcuccg acgugcccca ggggccgagc gacucccaga uccugcaggg ccugugcgcc      180

agcgaggggc ccuccaccag cguccucccc acguccgcgg agggccccag caccuucgug      240

ccgcccacca ucuccgaggc cagcuccgcc agcggccagc ccaccaucuc cgaggggccc      300

ggcacgagcg ugcugccgac ccccuccgag gggcugagca ccagcggccc gcccaccauc      360

uccaaggggc ucugcacgag cgucacccug gccgcguccg agggccgcaa caccagccgg      420

ccgcccaccu ccagcgagga gcccuccacg agcgugccgc ccaccgccuc cgaggugccc      480

agcaccuccc ugccgcccac ccccggcgag gggacgagca ccuccguccc gcccaccgcc      540

uacgagggcc ccagcaccuc cguggugccc acgcccgacg aggggcccag caccuccguc      600

cuccccaccc ccggcgaggg ccccgggacc agcgugcccc uggccgccac ggagggccug      660

uccaccagcg ugcaggcgac cccggacgag gggcccagca ccuccguccc gcccacggcc      720

accgagggcc ucagcacccc cgugccgccc acccgcgacg aggggcccuc cacgagcgug      780

cccgccaccc ccggcgaggg ccccuccacc agcguccugc ccgccgccuc cgacgggcag      840

agcaucuccc uggugccgac ccggggcaag gggagcucca cgagcgugcc gcccaccgcg      900

accgagggcc ucuccaccag cguccagccc accgccgggg agggcuccag cacguccgug      960

ccgcccaccc ccggcggggg ccugagcacc agcgugccgc ccaccgccac ggaggagcug     1020

uccaccagcg ucccgcccac ccccggggag ggccccucca ccagcgugcu ccccaucccc     1080

ggggagggcc uguccacgag cgucccgccc accgccuccg acggcagcga caccuccgug     1140

ccgcccaccc ccggggaggg cgccagcacg cuggugcagc ccaccgcgcc cgacgggccc     1200

ggcuccagcg uccuccccaa ccccggcgag gggcccucca cccuguucag cuccagcgcc     1260

uccguggacc gcaaccccag caagugcucc cuggugcucc cgagcccccg ggucaccaag     1320

gccagcgugg acuccgacag cgagggcccc aagggggccg agggccccau cgaguucgag     1380

gugcugcgcg acugcgaguc cccgaacagc aucuccauca uggggcugaa cacgagccgg     1440

gucgccauca cccucaagcc ccaggacccc auggagcaga acguggcgga gcugcugcag     1500

uuccuccugg ugaaggacca guccaaguac cccauccgcg agagcgagau gcgggaguac     1560

aucgucaagg aguaccgcaa ccaguucccg gagauccugc ggcgcgccgc cgcccaccuc     1620

gagugcaucu uccgguucga gcugcgcgag cuggaccccg aggcgcacac cuacauccuc     1680

cugaacaagc ugggccccgu gcccuucgag ggccucgagg aguccccgaa cgggcccaag     1740

augggccugc ugaugaugau ccucgggcag aucuuccuga acggcaacca ggccaaggag     1800

gccgagaucu gggagaugcu guggcggaug ggggugcagc gcgagcgccg gcucagcauc     1860

uucggcaacc ccaagcgccu gcuguccguc gaguucgugu ggcagcggua ccucgacuac     1920

cgcccgguga ccgacugcaa gcccgucgag uacgaguucu ucuggggccc ccggagccac     1980

cuggagacga ccaagaugaa gauccugaag uucauggcca agaucuacaa caaggacccc     2040

auggacuggc cggagaagua caacgaggcc cuggaggagg acgcggcccg cgccuucgcc     2100

gagggguggc aggcccuccc ccacuuccgg cgccccuucu ucgaggaggc ggccgccgag     2160

gugcccuccc cggacagcga gguguccagc uacuccagca aguacgcgcc ccacuccugg     2220

cccgagagcc ggcuggagag caaggcccgc aagcuggucc agcuguuccu ccugauggac     2280

uccaccaagc uccccauccc gaagaagggc auccuguacu acaucgggcg ggagugcagc     2340

aagguguucc ccgaccugcu caaccgcgcc gcccggaccc ugaaccacgu guacggcacg     2400

gagcuggucg ugcucgaccc ccgcaaccac uccuacaccc uguacaaccg gcgcgagaug     2460

gaggagaccg aggagaucgu ggacagcccc aaccggccgg ggaacaacuu ccugaugcag     2520

guccucuccu ucaucuucau caugggcaac cacgcccgcg agagcgccgu gugggcguuc     2580

cugcggggcc ugggggugca ggccggccgc aagcacguca ucacgugccg cuaccucucc     2640

cagcgguaca ucgacagccu gcgcgugccc gacuccgacc ccgugcagua cgaguucguc     2700

ugggggcccc gggcccgccu ggagaccagc aagaugaagg cccuccggua cguggcccgc     2760

auccaccgga aggagccgca ggacuggccc cagcaguacc gcgaggcgau ggaggacgag     2820

gccaaccggg ccgacguggg ccaccgccag aucuucgucc acaacuuccg guga           2874


<210>  2396
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2396
augucccucg ucucccagaa cucccgccgc cgccgccgcc gcgucgccaa ggccaccgcc       60

cacaacuccu ccuggggcga gaugcaggcc cccaacgccc ccggccuccc cgccgacguc      120

cccggcuccg acguccccca gggccccucc gacucccaga uccuccaggg ccucugcgcc      180

uccgagggcc ccuccaccuc cguccucccc accuccgccg agggccccuc caccuucguc      240

ccccccacca ucuccgaggc cuccuccgcc uccggccagc ccaccaucuc cgagggcccc      300

ggcaccuccg uccuccccac ccccuccgag ggccucucca ccuccggccc ccccaccauc      360

uccaagggcc ucugcaccuc cgucacccuc gccgccuccg agggccgcaa caccucccgc      420

ccccccaccu ccuccgagga gcccuccacc uccguccccc ccaccgccuc cgaggucccc      480

uccaccuccc ucccccccac ccccggcgag ggcaccucca ccuccguccc ccccaccgcc      540

uacgagggcc ccuccaccuc cgucgucccc acccccgacg agggccccuc caccuccguc      600

cuccccaccc ccggcgaggg ccccggcacc uccguccccc ucgccgccac cgagggccuc      660

uccaccuccg uccaggccac ccccgacgag ggccccucca ccuccguccc ccccaccgcc      720

accgagggcc ucuccacccc cguccccccc acccgcgacg agggccccuc caccuccguc      780

cccgccaccc ccggcgaggg ccccuccacc uccguccucc ccgccgccuc cgacggccag      840

uccaucuccc ucguccccac ccgcggcaag ggcuccucca ccuccguccc ccccaccgcc      900

accgagggcc ucuccaccuc cguccagccc accgccggcg agggcuccuc caccuccguc      960

ccccccaccc ccggcggcgg ccucuccacc uccguccccc ccaccgccac cgaggagcuc     1020

uccaccuccg ucccccccac ccccggcgag ggccccucca ccuccguccu ccccaucccc     1080

ggcgagggcc ucuccaccuc cguccccccc accgccuccg acggcuccga caccuccguc     1140

ccccccaccc ccggcgaggg cgccuccacc cucguccagc ccaccgcccc cgacggcccc     1200

ggcuccuccg uccuccccaa ccccggcgag ggccccucca cccucuucuc cuccuccgcc     1260

uccgucgacc gcaaccccuc caagugcucc cucguccucc ccuccccccg cgucaccaag     1320

gccuccgucg acuccgacuc cgagggcccc aagggcgccg agggccccau cgaguucgag     1380

guccuccgcg acugcgaguc ccccaacucc aucuccauca ugggccucaa caccucccgc     1440

gucgccauca cccucaagcc ccaggacccc auggagcaga acgucgccga gcuccuccag     1500

uuccuccucg ucaaggacca guccaaguac cccauccgcg aguccgagau gcgcgaguac     1560

aucgucaagg aguaccgcaa ccaguucccc gagauccucc gccgcgccgc cgcccaccuc     1620

gagugcaucu uccgcuucga gcuccgcgag cucgaccccg aggcccacac cuacauccuc     1680

cucaacaagc ucggccccgu ccccuucgag ggccucgagg agucccccaa cggccccaag     1740

augggccucc ucaugaugau ccucggccag aucuuccuca acggcaacca ggccaaggag     1800

gccgagaucu gggagaugcu cuggcgcaug ggcguccagc gcgagcgccg ccucuccauc     1860

uucggcaacc ccaagcgccu ccucuccguc gaguucgucu ggcagcgcua ccucgacuac     1920

cgccccguca ccgacugcaa gcccgucgag uacgaguucu ucuggggccc ccgcucccac     1980

cucgagacca ccaagaugaa gauccucaag uucauggcca agaucuacaa caaggacccc     2040

auggacuggc ccgagaagua caacgaggcc cucgaggagg acgccgcccg cgccuucgcc     2100

gagggcuggc aggcccuccc ccacuuccgc cgccccuucu ucgaggaggc cgccgccgag     2160

guccccuccc ccgacuccga ggucuccucc uacuccucca aguacgcccc ccacuccugg     2220

cccgaguccc gccucgaguc caaggcccgc aagcucgucc agcucuuccu ccucauggac     2280

uccaccaagc uccccauccc caagaagggc auccucuacu acaucggccg cgagugcucc     2340

aaggucuucc ccgaccuccu caaccgcgcc gcccgcaccc ucaaccacgu cuacggcacc     2400

gagcucgucg uccucgaccc ccgcaaccac uccuacaccc ucuacaaccg ccgcgagaug     2460

gaggagaccg aggagaucgu cgacuccccc aaccgccccg gcaacaacuu ccucaugcag     2520

guccucuccu ucaucuucau caugggcaac cacgcccgcg aguccgccgu cugggccuuc     2580

cuccgcggcc ucggcgucca ggccggccgc aagcacguca ucaccugccg cuaccucucc     2640

cagcgcuaca ucgacucccu ccgcgucccc gacuccgacc ccguccagua cgaguucguc     2700

uggggccccc gcgcccgccu cgagaccucc aagaugaagg cccuccgcua cgucgcccgc     2760

auccaccgca aggagcccca ggacuggccc cagcaguacc gcgaggccau ggaggacgag     2820

gccaaccgcg ccgacgucgg ccaccgccag aucuucgucc acaacuuccg cuga           2874


<210>  2397
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2397
augagccugg ugucccagaa cucuagaagg cggcgccgac gugucgccaa ggcuaccgca       60

cacaauucaa guuggggcga gaugcaagcc cccaacgcgc cugggcuccc agcugacguu      120

ccgggaagcg augugcccca ggguccuucc gacucucaga uccuucaggg ccugugcgcc      180

ucggaagggc caucaacaag cguauugccc acgagugcag agggaccuuc cacuuucgug      240

ccacccacca uuucugaagc cagcuccgcu ucaggccaac cuacaauaag ugagggucca      300

gggacuagcg ucuuaccgac ccccucugaa ggacugucca caucaggccc uccaaccauc      360

agcaaaggcc uauguacaag ugugacucuc gcagccucug aggggagaaa uaccuccagg      420

cccccuacga gcucggagga accaucuacu uccguucccc cgaccgcuuc agaggugccu      480

aguacaagcc ugcccccaac uccuggagaa gguaccucca caucuguccc uccaaccgcc      540

uacgagggcc ccagcacguc agugguaccu acuccagaug aggggccgag uacauccguu      600

cuucccaccc cuggagaagg cccagguacu agcgugcccc uggcggcaac agagggguug      660

ucuaccucag uccaggccac gccugacgaa ggaccaagua ccagcgugcc cccgacagcu      720

acugagggcc ucuccacccc ugugccaccc acacgggaug aaggcccuuc uacuucgguc      780

cccgccaccc caggggaggg accuagcaca uccguucugc ccgcagcuuc agacggucag      840

aguauuucuc uggugccaac ccgcggcaag gggagcucca cuucaguacc gccuacggcc      900

acagagggac ucagcaccuc ugugcagccc acugcgggcg aagguuccag uaccagcguc      960

ccacccacac cugggggcgg auuaucuacc uccgugccac ccacugccac agaggaacug     1020

ucaacgagug uuccuccgac cccaggcgag gggcccagca cuucggugcu uccuauccca     1080

ggagaagguu uguccacauc ugugcccccu accgcaagcg auggcucaga cacaaguguc     1140

ccgcccacuc caggggaggg agcuuccacc cugguacaac cuacggcccc cgauggccca     1200

gguucuagcg uucuaccuaa ccccggggag ggcccaucca cccucuuuuc aagcagugcu     1260

ucuguggaca gaaauccguc caaaugcagc cugguccuuc cuucgcccag ggugacaaag     1320

gccucagucg auucugacag ugaaggacca aaaggcgcag aggggcccau ugaguucgaa     1380

gugcugcggg auugugaauc cccuaacagc aucucuauaa ugggauugaa uacuagccgc     1440

guugccauca cccucaagcc acaggacccc auggagcaga acguggcuga gcuguuacag     1500

uuucugcucg uaaaggacca auccaaauau ccuauucgag aaucagagau gagagaauac     1560

aucgucaagg aguauaggaa ucaguucccg gagauucuuc ggcgugcggc agcccaucug     1620

gaaugcaucu uucgcuucga guugagagaa cuagauccag aggcucacac auacauacug     1680

cucaacaaac ugggucccgu gccuuuugaa ggccuugagg agagucccaa ugggccaaag     1740

augggacugu ugaugaugau ucucggccag aucuuccuga acgguaauca agccaaagaa     1800

gcagagauuu gggaaauguu auggaggaug gggguucagc gggagcgacg ccugagcauc     1860

uuuggcaacc cuaagagacu acucucugug gaguucgucu ggcagaggua ucuggacuac     1920

cggcccguga cugauuguaa gccaguagaa uaugaguuuu ucuggggacc ucgcucccau     1980

cuugaaacca cgaaaaugaa gaucuugaaa uuuauggcca agauuuacaa uaaagacccg     2040

auggauuggc ccgagaagua caacgaagcu cuggaggaag acgccgcaag agcguucgcu     2100

gagggcuggc aggcccuccc acacuucagg cgucccuuuu ucgaggaagc agccgcugag     2160

gugcccucac cagauaguga aguuagcucc uauucuucga aauacgcccc ucauagcugg     2220

cccgagucac ggcuggaguc caaggcacga aaacuugucc aacuguuuuu gcucauggac     2280

aguacaaagc ugccgauacc aaagaaaggg aucuuauauu acauuggaag agaaugcucu     2340

aagguguucc cugaucugcu aaacagggcu gcccgcaccc ucaaucacgu guauggcacu     2400

gagcuggucg uucuugaccc ccggaaccac agcuacacau uguauaauag aagggaaaug     2460

gaggaaaccg aggagaucgu ggauucccca aaccgccccg guaauaacuu ucugaugcaa     2520

gugcucucau ucauauuuau uauggggaau caugcgcgag aaucugccgu augggcuuuc     2580

cugcggggau uaggcgucca ggcaggucgu aaacacguga ucacuuguag auaccugagc     2640

cagagguaca ucgacagucu ucgcguuccu gacuccgauc cggugcagua ugaguuuguc     2700

uggggccccc gggccagauu ggaaaccagc aagaugaagg cucucaggua cguggcccgc     2760

auucaucgaa aagagccaca ggacuggccu cagcaguauc gggaagcaau ggaggaugag     2820

gcgaacagag ccgacguugg gcacaggcaa aucuucgugc acaauuuucg uuga           2874


<210>  2398
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2398
augagccugg ugagccagaa cagcagaaga agaagaagaa gaguggccaa ggccaccgcc       60

cacaacagca gcuggggcga gaugcaggcc cccaacgccc ccggccugcc cgccgacgug      120

cccggcagcg acgugcccca gggccccagc gacagccaga uccugcaggg ccugugcgcc      180

agcgagggcc ccagcaccag cgugcugccc accagcgccg agggccccag caccuucgug      240

ccccccacca ucagcgaggc cagcagcgcc agcggccagc ccaccaucag cgagggcccc      300

ggcaccagcg ugcugcccac ccccagcgag ggccugagca ccagcggccc ccccaccauc      360

agcaagggcc ugugcaccag cgugacccug gccgccagcg agggcagaaa caccagcaga      420

ccccccacca gcagcgagga gcccagcacc agcgugcccc ccaccgccag cgaggugccc      480

agcaccagcc ugccccccac ccccggcgag ggcaccagca ccagcgugcc ccccaccgcc      540

uacgagggcc ccagcaccag cguggugccc acccccgacg agggccccag caccagcgug      600

cugcccaccc ccggcgaggg ccccggcacc agcgugcccc uggccgccac cgagggccug      660

agcaccagcg ugcaggccac ccccgacgag ggccccagca ccagcgugcc ccccaccgcc      720

accgagggcc ugagcacccc cgugcccccc accagagacg agggccccag caccagcgug      780

cccgccaccc ccggcgaggg ccccagcacc agcgugcugc ccgccgccag cgacggccag      840

agcaucagcc uggugcccac cagaggcaag ggcagcagca ccagcgugcc ccccaccgcc      900

accgagggcc ugagcaccag cgugcagccc accgccggcg agggcagcag caccagcgug      960

ccccccaccc ccggcggcgg ccugagcacc agcgugcccc ccaccgccac cgaggagcug     1020

agcaccagcg ugccccccac ccccggcgag ggccccagca ccagcgugcu gcccaucccc     1080

ggcgagggcc ugagcaccag cgugcccccc accgccagcg acggcagcga caccagcgug     1140

ccccccaccc ccggcgaggg cgccagcacc cuggugcagc ccaccgcccc cgacggcccc     1200

ggcagcagcg ugcugcccaa ccccggcgag ggccccagca cccuguucag cagcagcgcc     1260

agcguggaca gaaaccccag caagugcagc cuggugcugc ccagccccag agugaccaag     1320

gccagcgugg acagcgacag cgagggcccc aagggcgccg agggccccau cgaguucgag     1380

gugcugagag acugcgagag ccccaacagc aucagcauca ugggccugaa caccagcaga     1440

guggccauca cccugaagcc ccaggacccc auggagcaga acguggccga gcugcugcag     1500

uuccugcugg ugaaggacca gagcaaguac cccaucagag agagcgagau gagagaguac     1560

aucgugaagg aguacagaaa ccaguucccc gagauccuga gaagagccgc cgcccaccug     1620

gagugcaucu ucagauucga gcugagagag cuggaccccg aggcccacac cuacauccug     1680

cugaacaagc ugggccccgu gcccuucgag ggccuggagg agagccccaa cggccccaag     1740

augggccugc ugaugaugau ccugggccag aucuuccuga acggcaacca ggccaaggag     1800

gccgagaucu gggagaugcu guggagaaug ggcgugcaga gagagagaag acugagcauc     1860

uucggcaacc ccaagagacu gcugagcgug gaguucgugu ggcagagaua ccuggacuac     1920

agacccguga ccgacugcaa gcccguggag uacgaguucu ucuggggccc cagaagccac     1980

cuggagacca ccaagaugaa gauccugaag uucauggcca agaucuacaa caaggacccc     2040

auggacuggc ccgagaagua caacgaggcc cuggaggagg acgccgccag agccuucgcc     2100

gagggcuggc aggcccugcc ccacuucaga agacccuucu ucgaggaggc cgccgccgag     2160

gugcccagcc ccgacagcga ggugagcagc uacagcagca aguacgcccc ccacagcugg     2220

cccgagagca gacuggagag caaggccaga aagcuggugc agcuguuccu gcugauggac     2280

agcaccaagc ugcccauccc caagaagggc auccuguacu acaucggcag agagugcagc     2340

aagguguucc ccgaccugcu gaacagagcc gccagaaccc ugaaccacgu guacggcacc     2400

gagcuggugg ugcuggaccc cagaaaccac agcuacaccc uguacaacag aagagagaug     2460

gaggagaccg aggagaucgu ggacagcccc aacagacccg gcaacaacuu ccugaugcag     2520

gugcugagcu ucaucuucau caugggcaac cacgccagag agagcgccgu gugggccuuc     2580

cugagaggcc ugggcgugca ggccggcaga aagcacguga ucaccugcag auaccugagc     2640

cagagauaca ucgacagccu gagagugccc gacagcgacc ccgugcagua cgaguucgug     2700

uggggcccca gagccagacu ggagaccagc aagaugaagg cccugagaua cguggccaga     2760

auccacagaa aggagcccca ggacuggccc cagcaguaca gagaggccau ggaggacgag     2820

gccaacagag ccgacguggg ccacagacag aucuucgugc acaacuucag auga           2874


<210>  2399
<211>  2874
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-E1_(MAGE1)__Homo_sapiens__AAM08354

<400>  2399
augagccugg ugucccagaa cucuagacgg cgcagacggc gcgucgccaa ggcuaccgcc       60

cacaauagcu ccuggggcga gaugcaagcg cccaacgcuc cugggcuccc ggccgacguu      120

cccggaucug augugccuca gggccccagc gacucccaga uccugcaggg gcuuugcgcc      180

ucugaaggac cuagcacauc cgugcugccc acgagcgcug agggcccuuc uaccuucguc      240

ccgcccacaa uuuccgaagc cagcucugcu uccgggcaac cuaccaucag cgagggaccc      300

ggcacaucug ugcucccuac ccccuccgaa ggccugagca cauccgggcc gccuaccauu      360

ucuaaaggac uuuguacgag cguuacccug gccgcguccg agggcagaaa uacaagccgg      420

cccccuaccu cuuccgagga acccagcaca ucugugcccc cuaccgccag cgaggucccg      480

uccacgucuc ugcccccuac acccggggaa ggaaccagca cauccgugcc ucccaccgcu      540

uacgagggcc cgagcaccuc uguugugccu acacccgaug aggggccuuc cacgagcguc      600

cuccccaccc cuggagaagg ccccggcaca ucugugccgc uggccgcuac cgaggggcuc      660

uccacaagcg ugcaggccac cccugacgaa ggacccucca cgucugugcc cccuacagcg      720

accgagggcc ugagcacccc gguucccccu acacgcgaug aagggcccuc caccucugug      780

ccugccacac ccggagaggg cccuagcacg uccgugcuuc ccgcugccag cgacgggcag      840

ucuaucuccc uggucccgac cagaggaaag ggcagcucua cauccgugcc ucccaccgcu      900

acagagggcc ucagcaccuc uguucagccu acggccgggg aaggaagcuc caccagcgug      960

cccccgacac cuggcggggg acugucuacc uccgugcccc cuacagccac cgaggaacuu     1020

agcacguccg ucccucccac acccggcgag gggccgucua ccagcguucu gcccauuccu     1080

ggcgaaggac ucuccacauc ugugcccccu accgcuagcg auggcuccga caccucugug     1140

cccccuacac cgggggaggg agcgagcacg cugguccaac ccaccgcccc ugauggcccc     1200

ggguccagcg uccugccuaa ccccggagag ggcccgucua cacucuuuuc cagcucugcu     1260

uccguggacc ggaauccuag caaaugcucu cugguucuuc ccagcccccg cgugaccaag     1320

gccuccgucg auuccgacag cgaagggccu aaaggcgccg agggacccau cgaguucgaa     1380

gugcugagag auugugaauc uccuaacagc aucuccauua ugggccucaa uacaucucgg     1440

guugcuauca cccugaagcc gcaggacccc auggagcaga acguggccga gcuucugcag     1500

uuucuccugg ucaaggacca aagcaaauau ccuauucgcg aauccgagau gagagaauac     1560

aucgugaagg aguaucggaa ucaguucccc gagauucugc gcagagcggc ugcccaucuc     1620

gaaugcaucu uucgguucga gcugagagaa cuugauccug aggcccacac guacauucug     1680

cucaacaaac uggggcccgu gccguuugaa ggacuugagg agucuccuaa uggccccaag     1740

auggggcugc ucaugaugau ccugggacag aucuuccuga acggcaauca agcuaaagaa     1800

gccgagauuu gggaaaugcu cuggcgcaug gggguucagc gggagagacg ccugagcauc     1860

uuuggcaacc cuaagcggcu ucuguccguc gaguucgugu ggcagagaua ucucgacuac     1920

cgccccguga cagauuguaa gccugucgaa uaugaguuuu ucuggggacc ccggucucau     1980

cuggaaacca ccaaaaugaa gauucugaaa uuuauggcua agaucuacaa uaaagacccg     2040

auggauuggc cugagaagua caacgaagcc cuugaggaag acgcggccag agcuuucgcc     2100

gagggcuggc aggcucuccc ccacuuccgc cggcccuuuu ucgaggaagc cgcggccgag     2160

gugccuagcc cggauuccga aguuagcucu uauuccagca aauacgcucc ccauucuugg     2220

ccugagucca gacuggagag caaggcccgc aagcuggugc aacucuuucu gcuuauggac     2280

uccacaaaac ugcccauucc uaagaaaggg auccucuauu acaucggacg ggaaugcucu     2340

aaggucuucc ccgaucugcu gaacagagcu gcccggaccc uuaaucacgu guauggcaca     2400

gagcucguug ugcuggaccc ucgcaaccac agcuacacgc uguauaauag acgggaaaug     2460

gaggaaaccg aggagauugu cgauuccccg aacagacccg ggaauaacuu ucucaugcag     2520

guccugagcu ucaucuuuau uaugggaaau caugcccgcg aaucugcugu uugggcguuc     2580

cuucggggcc ugggggugca ggccggcaga aaacacguca ucacaugucg cuaccucucc     2640

cagagauaca uugacagccu gcgggugccu gacucugauc ccgugcaaua ugaguuuguc     2700

uggggaccuc gcgcuagacu ggaaaccagc aagaugaagg cccuucggua cguugcccgc     2760

auccauagaa aagagcccca ggacuggccg cagcaguauc gggaagcuau ggaggaugag     2820

gccaaccgcg cggacguggg ccacagacaa aucuucgugc acaauuuucg guga           2874


<210>  2400
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-E2__Homo_sapiens__Q8TD90

<400>  2400

Met Ser Leu Val Ser Gln Asn Ala Arg His Cys Ser Ala Glu Ile Thr 
1               5                   10                  15      


Ala Asp Tyr Gly Asp Gly Arg Gly Glu Ile Gln Ala Thr Asn Ala Ser 
            20                  25                  30          


Gly Ser Pro Thr Ser Met Leu Val Val Asp Ala Pro Gln Cys Pro Gln 
        35                  40                  45              


Ala Pro Ile Asn Ser Gln Cys Val Asn Thr Ser Gln Ala Val Gln Asp 
    50                  55                  60                  


Pro Asn Asp Leu Glu Val Leu Ile Asp Glu Gln Ser Arg Arg Leu Gly 
65                  70                  75                  80  


Ala Leu Arg Val His Asp Pro Leu Glu Asp Arg Ser Ile Ala Leu Val 
                85                  90                  95      


Asn Phe Met Arg Met Lys Ser Gln Thr Glu Gly Ser Ile Gln Gln Ser 
            100                 105                 110         


Glu Met Leu Glu Phe Leu Arg Glu Tyr Ser Asp Gln Phe Pro Glu Ile 
        115                 120                 125             


Leu Arg Arg Ala Ser Ala His Leu Asp Gln Val Phe Gly Leu Asn Leu 
    130                 135                 140                 


Arg Val Ile Asp Pro Gln Ala Asp Thr Tyr Asn Leu Val Ser Lys Arg 
145                 150                 155                 160 


Gly Phe Gln Ile Thr Asp Arg Ile Ala Glu Ser Leu Asp Met Pro Lys 
                165                 170                 175     


Ala Ser Leu Leu Ala Leu Val Leu Gly His Ile Leu Leu Asn Gly Asn 
            180                 185                 190         


Arg Ala Arg Glu Ala Ser Ile Trp Asp Leu Leu Leu Lys Val Asp Met 
        195                 200                 205             


Trp Asp Lys Pro Gln Arg Ile Asn Asn Leu Phe Gly Asn Thr Arg Asn 
    210                 215                 220                 


Leu Leu Thr Thr Asp Phe Val Cys Met Arg Phe Leu Glu Tyr Trp Pro 
225                 230                 235                 240 


Val Tyr Gly Thr Asn Pro Leu Glu Phe Glu Phe Leu Trp Gly Ser Arg 
                245                 250                 255     


Ala His Arg Glu Ile Thr Lys Met Glu Ala Leu Lys Phe Val Ser Asp 
            260                 265                 270         


Ala His Asp Glu Glu Pro Trp Ser Trp Pro Glu Glu Tyr Asn Lys Ala 
        275                 280                 285             


Leu Glu Gly Asp Lys Thr Lys Glu Arg Ser Leu Thr Ala Gly Leu Glu 
    290                 295                 300                 


Phe Trp Ser Glu Asp Thr Met Asn Asp Lys Ala Asn Asp Leu Val Gln 
305                 310                 315                 320 


Leu Ala Ile Ser Val Thr Glu Glu Met Leu Pro Ile His Gln Asp Glu 
                325                 330                 335     


Leu Leu Ala His Thr Gly Lys Glu Phe Glu Asp Val Phe Pro Asn Ile 
            340                 345                 350         


Leu Asn Arg Ala Thr Leu Ile Leu Asp Met Phe Tyr Gly Leu Ser Leu 
        355                 360                 365             


Ile Glu Val Asp Thr Ser Glu His Ile Tyr Leu Leu Val Gln Gln Pro 
    370                 375                 380                 


Glu Ser Glu Glu Glu Gln Val Met Leu Glu Ser Leu Gly Arg Pro Thr 
385                 390                 395                 400 


Gln Glu Tyr Val Met Pro Ile Leu Gly Leu Ile Phe Leu Met Gly Asn 
                405                 410                 415     


Arg Val Lys Glu Ala Asn Val Trp Asn Leu Leu Arg Arg Phe Ser Val 
            420                 425                 430         


Asp Val Gly Arg Lys His Ser Ile Thr Arg Lys Leu Met Arg Gln Arg 
        435                 440                 445             


Tyr Leu Glu Cys Arg Pro Leu Ser Tyr Ser Asn Pro Val Glu Tyr Glu 
    450                 455                 460                 


Leu Leu Trp Gly Pro Arg Ala His His Glu Thr Ile Lys Met Lys Val 
465                 470                 475                 480 


Leu Glu Tyr Met Ala Arg Leu Tyr Arg Lys Arg Pro Gln Asn Trp Pro 
                485                 490                 495     


Glu Gln Tyr Arg Glu Ala Val Glu Asp Glu Glu Ala Arg Ala Lys Ser 
            500                 505                 510         


Glu Ala Thr Ile Met Phe Phe Leu Asp Pro Thr 
        515                 520             


<210>  2401
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-E2__Homo_sapiens__AAH93964

<400>  2401
augucucugg uaagccagaa ugcacgccac uguagcgcag agaucacugc agauuacggc       60

gacggcagag gugaaauaca agcuacuaac gccuccgggu cccccaccuc caugcuaguc      120

guugaugccc cccagugccc ucaggcgcca aucaacucuc agugugucaa cacuucccag      180

gccguucagg acccgaauga ccuggagguc cugaucgacg agcaguccag acguuugggg      240

gcgcucaggg uccaugaccc ucuagaagac aggucgauug cuuuggugaa uuucaugaga      300

augaaaagcc agacggaggg gucuauccag caguccgaga ugcuggaguu ucucagagag      360

uacucagauc aguucccuga gauccucaga cgagccucag cucaccugga ccaggucuuu      420

ggguugaacc ugagaguuau ugauccucag gcugacaccu acaauuuagu cagcaaacgg      480

gguuuccaga ucaccgauag gauagcggag ucccuggaca ugccaaaagc aagucuccug      540

gcccuagucc uaggccacau ccucuugaau gggaaccgag caagagaggc cuccauuugg      600

gacuugcugc uaaaaguuga uaugugggau aagccucaga ggaucaacaa ccucuuuggg      660

aacacaagga accuccucac uacugacuuu gugugcaugc gauucuugga guacuggccg      720

guguauggca cuaauccccu ugaguuugag uucuuguggg gcucuagagc ccacagggaa      780

aucacaaaga uggaagcccu gaaguuugug ucagaugccc augaugaaga acccuggagc      840

uggccagaag aauauaauaa ggcccuggaa ggugacaaaa ccaaagaaag aagccugacu      900

gcuggcuuag aguucugguc ggaggacacu augaaugaua aggcaaauga uuugguccag      960

uuggcuauua gugucacuga ggagaugcug ccuauacauc aggaugagcu auuggcucac     1020

acuggcaaag aauuugagga uguguuccca aauauccuca auagagcuac ucuaauucuu     1080

gauauguucu auggguuguc ucugauugag guugauacca gugagcacau cuaccuccuu     1140

guccagcaac cagaaucaga ggaagagcaa gugaugcuag agagccuggg gagacccacu     1200

caagaauaug uaaugccaau ccuagguuug aucuuccuga ugggcaaccg ugucaaagag     1260

gccaaugucu ggaacuugcu ucgaagauuu aguguggaug uagggagaaa gcauuccauc     1320

acccguaagc uuaugagaca gcgcuaucug gaaugcaggc cacuguccua cucuaaucca     1380

guugaauaug agcuucuaug ggguccucga gcucaccaug aaaccaucaa aaugaaaguc     1440

uuggaguaca uggccaggcu cuacagaaag cgaccacaga acuggccaga acaauauagg     1500

gaggcugugg aagaugagga ggccagagcc aaaucugagg caacuaucau guuuuuccuu     1560

gaccccacgu ga                                                         1572


<210>  2402
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-E2__Homo_sapiens__AAH93964

<400>  2402
augagccugg ugucccagaa cgcccgccac ugcagcgccg agaucaccgc ggacuacggc       60

gacgggcggg gcgagaucca ggccaccaac gccuccggga gccccacguc caugcucguc      120

guggacgccc cgcagugccc ccaggccccc aucaacagcc agugcgugaa caccucccag      180

gcgguccagg accccaacga ccuggaggug cugaucgacg agcagagccg ccggcucggc      240

gcccugcgcg ugcacgaccc gcuggaggac cgguccaucg cccucgucaa cuucaugcgc      300

augaaguccc agaccgaggg gagcauccag cagagcgaga ugcuggaguu ccugcgggag      360

uacuccgacc aguuccccga gauccuccgc cgggccagcg cgcaccugga ccagguguuc      420

ggccugaacc uccgcgugau cgacccccag gccgacaccu acaaccuggu cuccaagcgg      480

ggcuuccaga ucacggaccg caucgccgag agccuggaca ugcccaaggc cucccuccug      540

gcccuggugc ucgggcacau ccugcugaac ggcaaccggg cgcgcgaggc cagcaucugg      600

gaccuccugc ugaaggugga caugugggac aagccgcagc ggaucaacaa ccucuucggg      660

aacacccgca accugcugac caccgacuuc gucugcaugc gguuccucga guacuggccc      720

guguacggca cgaacccccu ggaguucgag uuccuguggg ggucccgcgc ccaccgggag      780

aucaccaaga uggaggcccu caaguucgug agcgacgccc acgacgagga gcccuggagc      840

uggccggagg aguacaacaa ggcgcuggag ggcgacaaga ccaaggagcg cucccugacc      900

gccggccucg aguucuggag cgaggacacg augaacgaca aggccaacga ccugguccag      960

cuggccaucu ccgugaccga ggagaugcuc cccauccacc aggacgagcu gcuggcccac     1020

accgggaagg aguucgagga cguguucccc aacauccuca accgggcgac ccugauccug     1080

gacauguucu acggccucag ccugaucgag gucgacacgu ccgagcacau cuaccugcuc     1140

gugcagcagc ccgagagcga ggaggagcag gucaugcugg agucccuggg gcgcccgacc     1200

caggaguacg ugaugcccau ccucggccug aucuuccuga ugggcaaccg cgugaaggag     1260

gccaacgugu ggaaccugcu ccggcgcuuc agcgucgacg uggggcggaa gcacuccauc     1320

acccgcaagc ugaugcggca gcgcuaccug gagugccggc cccucagcua cuccaacccc     1380

gucgaguacg agcugcugug gggcccgcgc gcccaccacg agaccaucaa gaugaaggug     1440

cucgaguaca uggcccggcu guaccgcaag cggccccaga acuggcccga gcaguaccgc     1500

gaggccgugg aggacgagga ggcgcgggcc aagagcgagg ccacgaucau guucuuccug     1560

gaccccaccu ga                                                         1572


<210>  2403
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-E2__Homo_sapiens__AAH93964

<400>  2403
augucccucg ucucccagaa cgcccgccac ugcuccgccg agaucaccgc cgacuacggc       60

gacggccgcg gcgagaucca ggccaccaac gccuccggcu cccccaccuc caugcucguc      120

gucgacgccc cccagugccc ccaggccccc aucaacuccc agugcgucaa caccucccag      180

gccguccagg accccaacga ccucgagguc cucaucgacg agcagucccg ccgccucggc      240

gcccuccgcg uccacgaccc ccucgaggac cgcuccaucg cccucgucaa cuucaugcgc      300

augaaguccc agaccgaggg cuccauccag caguccgaga ugcucgaguu ccuccgcgag      360

uacuccgacc aguuccccga gauccuccgc cgcgccuccg cccaccucga ccaggucuuc      420

ggccucaacc uccgcgucau cgacccccag gccgacaccu acaaccucgu cuccaagcgc      480

ggcuuccaga ucaccgaccg caucgccgag ucccucgaca ugcccaaggc cucccuccuc      540

gcccucgucc ucggccacau ccuccucaac ggcaaccgcg cccgcgaggc cuccaucugg      600

gaccuccucc ucaaggucga caugugggac aagccccagc gcaucaacaa ccucuucggc      660

aacacccgca accuccucac caccgacuuc gucugcaugc gcuuccucga guacuggccc      720

gucuacggca ccaacccccu cgaguucgag uuccucuggg gcucccgcgc ccaccgcgag      780

aucaccaaga uggaggcccu caaguucguc uccgacgccc acgacgagga gcccuggucc      840

uggcccgagg aguacaacaa ggcccucgag ggcgacaaga ccaaggagcg cucccucacc      900

gccggccucg aguucugguc cgaggacacc augaacgaca aggccaacga ccucguccag      960

cucgccaucu ccgucaccga ggagaugcuc cccauccacc aggacgagcu ccucgcccac     1020

accggcaagg aguucgagga cgucuucccc aacauccuca accgcgccac ccucauccuc     1080

gacauguucu acggccucuc ccucaucgag gucgacaccu ccgagcacau cuaccuccuc     1140

guccagcagc ccgaguccga ggaggagcag gucaugcucg agucccucgg ccgccccacc     1200

caggaguacg ucaugcccau ccucggccuc aucuuccuca ugggcaaccg cgucaaggag     1260

gccaacgucu ggaaccuccu ccgccgcuuc uccgucgacg ucggccgcaa gcacuccauc     1320

acccgcaagc ucaugcgcca gcgcuaccuc gagugccgcc cccucuccua cuccaacccc     1380

gucgaguacg agcuccucug gggcccccgc gcccaccacg agaccaucaa gaugaagguc     1440

cucgaguaca uggcccgccu cuaccgcaag cgcccccaga acuggcccga gcaguaccgc     1500

gaggccgucg aggacgagga ggcccgcgcc aaguccgagg ccaccaucau guucuuccuc     1560

gaccccaccu ga                                                         1572


<210>  2404
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-E2__Homo_sapiens__AAH93964

<400>  2404
augagccugg ugucccagaa cgccagacac ugcucugcug agaucaccgc agacuacggc       60

gaugggaggg gagaaauuca agccacaaau gcgucaggua gucccacuag caugcucguc      120

guugacgcuc cucagugucc acaggccccg auaaacuccc agugcgugaa uacgucucaa      180

gcaguacagg aucccaacga ccuugaggug cugaucgaug aacagucgcg gcgcuugggc      240

gccuuacgag uccaugaccc ucuggaggau cguucaauug cucuagugaa uuucaugaga      300

augaaaagcc agaccgaagg gaguauccaa caguccgaga ugcucgaguu ucugagggaa      360

uauucugacc aguucccaga gauucuucgg cgcgcaagcg cccaccugga ucagguuuuu      420

ggauugaacc ucagagugau cgacccccaa gcugauacau acaaucuggu cuccaagagg      480

ggcuuccaga uaacugaccg gaucgccgaa ucacuggaua ugccuaaggc gagucucuua      540

gcacuggugc uuggucauau uuugcugaac gggaaucgcg cccgagaggc uagcaucugg      600

gaccuacucc ugaaaguaga caugugggau aagccacaga gaauuaacaa ucuuuuugga      660

aacaccagga aucuguugac aaccgacuuc guuuguaugc gguuucucga guauuggccc      720

guguacggca cuaacccucu ggaguucgag uuuuuauggg gcucucgugc ccaccgcgaa      780

aucacaaaaa uggaggcacu gaaguucguc uccgaugcuc augacgaaga accaugguca      840

uggccggagg aauauaauaa ggcccucgag ggggauaaaa ccaaggaaag aagccuuacg      900

gcgggacugg aguuuuggag ugaagacacu augaacgaua aagccaacga cuuggugcaa      960

cuagcaauau cugugaccga ggagaugcug cccauucacc aggaugaacu ccuggcucac     1020

acagguaagg aguucgaaga cgucuuuccu aauauccuua acagggccac ucugauuuug     1080

gauauguucu acggccucuc ccugaucgag guugacacca gcgaacauau cuauuuacug     1140

gugcagcagc cagagucgga ggaggaacaa guaaugcuag aaucucucgg gcggcccaca     1200

caggaguacg ugaugccuau ucugggacuu auauucuuga ugggcaaucg agucaaagag     1260

gcuaacgugu ggaaucugcu ccgcagauuu uccguugacg uggguaggaa gcacucaauc     1320

acccggaagc ugaugcgcca gagauaccuu gaaugcaggc cacugaguua uagcaacccc     1380

gucgaguacg aauugcucug ggggccgcgu gcccaucacg agacgauuaa aaugaaggug     1440

cuggaauaua uggcacgguu auaccgaaaa agaccucaga auuggcccga gcaauauagg     1500

gaggccguag aagaugagga agcucgcgcg aaguccgagg caacuaucau guucuuucug     1560

gacccaacau ga                                                         1572


<210>  2405
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-E2__Homo_sapiens__AAH93964

<400>  2405
augagccugg ugagccagaa cgccagacac ugcagcgccg agaucaccgc cgacuacggc       60

gacggcagag gcgagaucca ggccaccaac gccagcggca gccccaccag caugcuggug      120

guggacgccc cccagugccc ccaggccccc aucaacagcc agugcgugaa caccagccag      180

gccgugcagg accccaacga ccuggaggug cugaucgacg agcagagcag aagacugggc      240

gcccugagag ugcacgaccc ccuggaggac agaagcaucg cccuggugaa cuucaugaga      300

augaagagcc agaccgaggg cagcauccag cagagcgaga ugcuggaguu ccugagagag      360

uacagcgacc aguuccccga gauccugaga agagccagcg cccaccugga ccagguguuc      420

ggccugaacc ugagagugau cgacccccag gccgacaccu acaaccuggu gagcaagaga      480

ggcuuccaga ucaccgacag aaucgccgag agccuggaca ugcccaaggc cagccugcug      540

gcccuggugc ugggccacau ccugcugaac ggcaacagag ccagagaggc cagcaucugg      600

gaccugcugc ugaaggugga caugugggac aagccccaga gaaucaacaa ccuguucggc      660

aacaccagaa accugcugac caccgacuuc gugugcauga gauuccugga guacuggccc      720

guguacggca ccaacccccu ggaguucgag uuccuguggg gcagcagagc ccacagagag      780

aucaccaaga uggaggcccu gaaguucgug agcgacgccc acgacgagga gcccuggagc      840

uggcccgagg aguacaacaa ggcccuggag ggcgacaaga ccaaggagag aagccugacc      900

gccggccugg aguucuggag cgaggacacc augaacgaca aggccaacga ccuggugcag      960

cuggccauca gcgugaccga ggagaugcug cccauccacc aggacgagcu gcuggcccac     1020

accggcaagg aguucgagga cguguucccc aacauccuga acagagccac ccugauccug     1080

gacauguucu acggccugag ccugaucgag guggacacca gcgagcacau cuaccugcug     1140

gugcagcagc ccgagagcga ggaggagcag gugaugcugg agagccuggg cagacccacc     1200

caggaguacg ugaugcccau ccugggccug aucuuccuga ugggcaacag agugaaggag     1260

gccaacgugu ggaaccugcu gagaagauuc agcguggacg ugggcagaaa gcacagcauc     1320

accagaaagc ugaugagaca gagauaccug gagugcagac cccugagcua cagcaacccc     1380

guggaguacg agcugcugug gggccccaga gcccaccacg agaccaucaa gaugaaggug     1440

cuggaguaca uggccagacu guacagaaag agaccccaga acuggcccga gcaguacaga     1500

gaggccgugg aggacgagga ggccagagcc aagagcgagg ccaccaucau guucuuccug     1560

gaccccaccu ga                                                         1572


<210>  2406
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-E2__Homo_sapiens__AAH93964

<400>  2406
augagccugg ugucccagaa cgccagacac ugcucugcug agaucaccgc cgacuacggc       60

gaugggcggg gagaaauuca agcgacaaau gcuagcggcu cccccacguc uaugcucguc      120

guugacgccc cucagugucc gcaggccccc aucaacagcc agugcgugaa uaccucccaa      180

gcugugcagg auccuaacga ccuggagguc cuuauugaug aacagucucg cagacugggg      240

gcccuccggg ugcaugaccc ccuggaggau cgcagcaucg cucuuguuaa uuucaugaga      300

augaaguccc agacagaagg aagcauucaa cagucugaga ugcuggaguu ucuccgggaa      360

uauuccgacc aguucccuga gauccugcgc agagccagcg cgcaccugga ucagguguuu      420

ggccucaacc ugcgggucau cgacccccaa gccgauaccu acaaucuugu gucuaaacgc      480

ggguuccaga uuacagacag aaucgcugaa ucccuggaua ugccuaaggc cagccuccug      540

gcucuuguuc ugggacauau ucuccugaac ggcaaucggg cccgcgaggc gucuaucugg      600

gaccugcucc ugaaagugga caugugggau aagccgcaga gaauuaacaa ucuuuuuggc      660

aacacccgga aucugcucac aaccgacuuc gucuguaugc gcuuucugga guauuggccc      720

guguacggga cgaacccucu ugaguucgag uuucuguggg gauccagagc ccaccgggaa      780

aucaccaaaa uggaggcucu caaguucgug agcgaugccc augacgaaga acccuggucc      840

uggccugagg aauauaauaa ggcucuggag ggcgauaaaa caaaggaaag aucucugacc      900

gccgggcucg aguuuuggag cgaagacaca augaacgaua aagccaacga ccugguccaa      960

cuugcuauuu ccguuaccga ggagaugcug cccauccacc aggaugaacu ccuggcgcac     1020

acgggaaagg aguucgaaga cguguuuccg aauauccuua accgcgccac acugauucuc     1080

gauauguucu acggccugag ccugaucgag guggacaccu cugaacauau uuaucuccug     1140

guccagcagc cugaguccga ggaggaacaa gugaugcuug aaagccuggg gcggcccaca     1200

caggaguacg uuaugccuau ccucggacug auuuuccuga ugggcaauag agugaaagag     1260

gcuaacgucu ggaaucuucu ccgccgguuu ucuguggacg uuggcagaaa gcacagcauc     1320

acccgcaagc ugaugcggca gagauaccug gaaugccgcc cccucuccua uucuaacccc     1380

guggaguacg aacugcuuug ggggccucgg gcccaucacg agaccaucaa aaugaagguc     1440

cuggaauaua uggccagacu cuaccgcaaa cggccgcaga auuggcccga gcaauauaga     1500

gaggcugugg aagaugagga agcccgggcu aagagcgagg cgacaauuau guucuuucug     1560

gacccuacgu ga                                                         1572


<210>  2407
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-F1__Homo_sapiens__Q9HAY2

<400>  2407

Met Leu Gln Thr Pro Glu Ser Arg Gly Leu Pro Val Pro Gln Ala Glu 
1               5                   10                  15      


Gly Glu Lys Asp Gly Gly His Asp Gly Glu Thr Arg Ala Pro Thr Ala 
            20                  25                  30          


Ser Gln Glu Arg Pro Lys Glu Glu Leu Gly Ala Gly Arg Glu Glu Gly 
        35                  40                  45              


Ala Ala Glu Pro Ala Leu Thr Arg Lys Gly Ala Arg Ala Leu Ala Ala 
    50                  55                  60                  


Lys Ala Leu Ala Arg Arg Arg Ala Tyr Arg Arg Leu Asn Arg Thr Val 
65                  70                  75                  80  


Ala Glu Leu Val Gln Phe Leu Leu Val Lys Asp Lys Lys Lys Ser Pro 
                85                  90                  95      


Ile Thr Arg Ser Glu Met Val Lys Tyr Val Ile Gly Asp Leu Lys Ile 
            100                 105                 110         


Leu Phe Pro Asp Ile Ile Ala Arg Ala Ala Glu His Leu Arg Tyr Val 
        115                 120                 125             


Phe Gly Phe Glu Leu Lys Gln Phe Asp Arg Lys His His Thr Tyr Ile 
    130                 135                 140                 


Leu Ile Asn Lys Leu Lys Pro Leu Glu Glu Glu Glu Glu Glu Asp Leu 
145                 150                 155                 160 


Gly Gly Asp Gly Pro Arg Leu Gly Leu Leu Met Met Ile Leu Gly Leu 
                165                 170                 175     


Ile Tyr Met Arg Gly Asn Ser Ala Arg Glu Ala Gln Val Trp Glu Met 
            180                 185                 190         


Leu Arg Arg Leu Gly Val Gln Pro Ser Lys Tyr His Phe Leu Phe Gly 
        195                 200                 205             


Tyr Pro Lys Arg Leu Ile Met Glu Asp Phe Val Gln Gln Arg Tyr Leu 
    210                 215                 220                 


Ser Tyr Arg Arg Val Pro His Thr Asn Pro Pro Glu Tyr Glu Phe Ser 
225                 230                 235                 240 


Trp Gly Pro Arg Ser Asn Leu Glu Ile Ser Lys Met Glu Val Leu Gly 
                245                 250                 255     


Phe Val Ala Lys Leu His Lys Lys Glu Pro Gln His Trp Pro Val Gln 
            260                 265                 270         


Tyr Arg Glu Ala Leu Ala Asp Glu Ala Asp Arg Ala Arg Ala Lys Ala 
        275                 280                 285             


Arg Ala Glu Ala Ser Met Arg Ala Arg Ala Ser Ala Arg Ala Gly Ile 
    290                 295                 300                 


His Leu Trp 
305         


<210>  2408
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2408
auguugcaga caccagagag cagggggcuc ccggucccgc aggccgaggg ggagaaggau       60

ggcggccaug auggugagac ccgggccccg accgccucgc aggagcgccc caaggaggag      120

cuuggcgccg ggagggagga gggggcugcg gagcccgccc ucacccggaa aggcgcgagg      180

gccuuggcgg ccaaagccuu ggcaaggcgc agggccuacc gccggcugaa ucggacggug      240

gcggaguugg ugcaguuccu ccuggugaaa gacaagaaga agagucccau cacacgcucg      300

gagaugguga aauacguuau uggagacuug aagauucugu ucccggacau caucgcaagg      360

gccgcagagc aucugcggua ugucuuuggu uuugagcuga aacaguuuga ccgcaagcac      420

cacacuuaca uccugaucaa caaacuaaaa ccucuggagg aggaggagga ggaggaucug      480

ggaggagaug gccccagauu gggucuguua augaugaucc ugggccuuau cuauaugaga      540

gguaauagcg ccagggaggc ccaggucugg gagaugcugc gucgguuggg ggugcaaccc      600

ucaaaguauc auuuccucuu uggguauccg aagaggcuua uuauggaaga uuuugugcag      660

cagcgauauc ucaguuacag gcgggugccu cacaccaauc caccagaaua ugaauucucu      720

uggggucccc gaagcaaccu ggaaaucagc aagauggaag uccugggguu cguggccaaa      780

cugcauaaga aggaaccgca gcacuggcca gugcaguacc gugaggcccu agcagacgag      840

gccgacaggg ccagagccaa ggccagagcu gaagccagua ugagggccag ggccagugcu      900

agggccggca uccaccucug guga                                             924


<210>  2409
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2409
augcugcaga cccccgagag ccgcggccuc ccggugcccc aggccgaggg ggagaaggac       60

ggcgggcacg acggcgagac ccgggccccc acggcguccc aggagcgccc caaggaggag      120

cugggggccg gccgggagga gggcgccgcc gagccggccc ugacccgcaa gggggcgcgg      180

gcccucgccg ccaaggcgcu ggcccgccgg cgcgccuacc ggcgccugaa ccggaccguc      240

gccgagcucg ugcaguuccu gcuggugaag gacaagaaga agucccccau cacccgcagc      300

gagaugguca aguacgugau cggcgaccuc aagauccugu uccccgacau caucgcccgg      360

gcggccgagc accuccgcua cguguucggg uucgagcuga agcaguucga ccggaagcac      420

cacacguaca uccugaucaa caagcugaag ccccucgagg aggaggagga ggaggaccug      480

ggcggggacg gcccgcgccu gggccuccug augaugaucc uggggcucau cuacaugcgg      540

ggcaacagcg cccgcgaggc ccaggucugg gagaugcugc ggcgccuggg ggugcagccc      600

uccaaguacc acuuccucuu cggcuacccc aagcggcuga ucauggagga cuucgugcag      660

cagcgcuacc ugagcuaccg ccgggucccc cacaccaacc cgcccgagua cgaguucucc      720

uggggccccc gcagcaaccu cgagaucucc aagauggagg ugcugggguu cguggccaag      780

cugcacaaga aggagcccca gcacuggccg guccaguacc gggaggcgcu cgccgacgag      840

gccgaccgcg cccgggccaa ggcgcgcgcc gaggccagca ugcgggcccg cgccuccgcg      900

cgggccggca uccaccugug guga                                             924


<210>  2410
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2410
augcuccaga cccccgaguc ccgcggccuc cccguccccc aggccgaggg cgagaaggac       60

ggcggccacg acggcgagac ccgcgccccc accgccuccc aggagcgccc caaggaggag      120

cucggcgccg gccgcgagga gggcgccgcc gagcccgccc ucacccgcaa gggcgcccgc      180

gcccucgccg ccaaggcccu cgcccgccgc cgcgccuacc gccgccucaa ccgcaccguc      240

gccgagcucg uccaguuccu ccucgucaag gacaagaaga agucccccau cacccgcucc      300

gagaugguca aguacgucau cggcgaccuc aagauccucu uccccgacau caucgcccgc      360

gccgccgagc accuccgcua cgucuucggc uucgagcuca agcaguucga ccgcaagcac      420

cacaccuaca uccucaucaa caagcucaag ccccucgagg aggaggagga ggaggaccuc      480

ggcggcgacg gcccccgccu cggccuccuc augaugaucc ucggccucau cuacaugcgc      540

ggcaacuccg cccgcgaggc ccaggucugg gagaugcucc gccgccucgg cguccagccc      600

uccaaguacc acuuccucuu cggcuacccc aagcgccuca ucauggagga cuucguccag      660

cagcgcuacc ucuccuaccg ccgcgucccc cacaccaacc cccccgagua cgaguucucc      720

uggggccccc gcuccaaccu cgagaucucc aagauggagg uccucggcuu cgucgccaag      780

cuccacaaga aggagcccca gcacuggccc guccaguacc gcgaggcccu cgccgacgag      840

gccgaccgcg cccgcgccaa ggcccgcgcc gaggccucca ugcgcgcccg cgccuccgcc      900

cgcgccggca uccaccucug guga                                             924


<210>  2411
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2411
augcugcaga cccccgagag cagaggccuc ccugugccac aagccgaagg ggagaaggac       60

ggaggucacg auggcgaaac aagggcuccg acugcauccc aggagcggcc caaagaagaa      120

cuuggggccg gacgcgagga aggcgcggcu gagccugccc ugacgcgaaa gggugcacgu      180

gccuuggcug caaaagccuu agcuagaagg cgggccuacc gcagacugaa caggaccguc      240

gcggagcuag uucaguuccu ccuggugaag gacaaaaaga agucuccaau cacacgguca      300

gagaugguaa aauaugugau uggggaucuu aagauacugu uucccgacau cauugcacgc      360

gccgcugagc auuugcgaua cgucuucgga uuugaacuca aacaguucga uagaaagcac      420

cauacuuaua uccugauuaa uaaacugaag ccucucgagg aagaggaaga ggaggacuua      480

ggcggcgaug ggccaaggcu gggacuuuug augaugaucc ugggucuaau auacaugcgg      540

ggcaacagug cccgugaagc acaagugugg gagaugcucc gcagacuggg gguucagccc      600

agcaaguauc acuuucuuuu cggauacccu aaaaggcuga ucauggaaga cuuugugcag      660

cagcgguauu uguccuaccg acgcguccca cauaccaauc cgcccgagua cgaguucucu      720

uggggcccua gaucgaaccu cgaaauuuca aagauggagg ugcuggguuu uguagcuaaa      780

uuacacaaga aagaaccaca acacuggccc guucaguaua gggaggcccu ggcggaugaa      840

gccgaccggg cacgcgcuaa ggccagagcu gaggccagca ugagggcacg ugccagugcu      900

cgggcgggga uccaucucug guga                                             924


<210>  2412
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2412
augcugcaga cccccgagag cagaggccug cccgugcccc aggccgaggg cgagaaggac       60

ggcggccacg acggcgagac cagagccccc accgccagcc aggagagacc caaggaggag      120

cugggcgccg gcagagagga gggcgccgcc gagcccgccc ugaccagaaa gggcgccaga      180

gcccuggccg ccaaggcccu ggccagaaga agagccuaca gaagacugaa cagaaccgug      240

gccgagcugg ugcaguuccu gcuggugaag gacaagaaga agagccccau caccagaagc      300

gagaugguga aguacgugau cggcgaccug aagauccugu uccccgacau caucgccaga      360

gccgccgagc accugagaua cguguucggc uucgagcuga agcaguucga cagaaagcac      420

cacaccuaca uccugaucaa caagcugaag ccccuggagg aggaggagga ggaggaccug      480

ggcggcgacg gccccagacu gggccugcug augaugaucc ugggccugau cuacaugaga      540

ggcaacagcg ccagagaggc ccaggugugg gagaugcuga gaagacuggg cgugcagccc      600

agcaaguacc acuuccuguu cggcuacccc aagagacuga ucauggagga cuucgugcag      660

cagagauacc ugagcuacag aagagugccc cacaccaacc cccccgagua cgaguucagc      720

uggggcccca gaagcaaccu ggagaucagc aagauggagg ugcugggcuu cguggccaag      780

cugcacaaga aggagcccca gcacuggccc gugcaguaca gagaggcccu ggccgacgag      840

gccgacagag ccagagccaa ggccagagcc gaggccagca ugagagccag agccagcgcc      900

agagccggca uccaccugug guga                                             924


<210>  2413
<211>  924
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-F1__Homo_sapiens__CCDS3269.1

<400>  2413
augcugcaga cccccgagag cagaggccuc ccugugccgc aagccgaagg ggagaaggac       60

ggaggccacg auggggaaac acgggcuccc acggccuccc aggagcgccc uaaagaagaa      120

cugggagcgg gcagagagga aggggcugcc gagcccgccc uuacccggaa gggagcucgc      180

gcccuggcug ccaaagcgcu cgccagacgg cgcgcuuaca gacggcugaa ccgcacaguc      240

gccgaacuug uucaguuccu gcucgugaag gacaaaaaga agucuccuau caccagaagc      300

gagaugguga aauaugucau uggcgaucug aagauccugu uucccgacau uaucgcucgg      360

gccgcggagc aucuccgcua cguguucggc uuugaacuga aacaguucga uagaaagcac      420

cauacauaua uucuuaucaa uaaacugaag ccucucgagg aagaggaaga ggaggaccuu      480

gggggagaug gcccgcggcu ggggcugcuc augaugaucc ugggacugau uuacaugcgc      540

ggcaacuccg ccagagaagc ucaaguuugg gagaugcucc ggagacuggg ggugcagccc      600

ucuaaguauc acuuucuuuu cggauacccu aaacgccuga ucauggaaga cuuuguccag      660

cagcgguauc ucagcuacag acgcgugccc cauaccaauc cucccgagua cgaguucucc      720

uggggcccgc ggucuaaccu ggagauuagc aagauggagg uucuuggcuu uguggccaaa      780

cugcacaaga aagaaccuca acacuggccc guccaguaua gagaggcucu cgccgaugaa      840

gccgaccgcg cucgggcgaa ggccagagcu gaggccucca ugcgcgcccg ggcuagcgcc      900

agagcgggga uccaucugug guga                                             924


<210>  2414
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGE-H1__Homo_sapiens__Q9H213

<400>  2414

Met Pro Arg Gly Arg Lys Ser Arg Arg Arg Arg Asn Ala Arg Ala Ala 
1               5                   10                  15      


Glu Glu Asn Arg Asn Asn Arg Lys Ile Gln Ala Ser Glu Ala Ser Glu 
            20                  25                  30          


Thr Pro Met Ala Ala Ser Val Val Ala Ser Thr Pro Glu Asp Asp Leu 
        35                  40                  45              


Ser Gly Pro Glu Glu Asp Pro Ser Thr Pro Glu Glu Ala Ser Thr Thr 
    50                  55                  60                  


Pro Glu Glu Ala Ser Ser Thr Ala Gln Ala Gln Lys Pro Ser Val Pro 
65                  70                  75                  80  


Arg Ser Asn Phe Gln Gly Thr Lys Lys Ser Leu Leu Met Ser Ile Leu 
                85                  90                  95      


Ala Leu Ile Phe Ile Met Gly Asn Ser Ala Lys Glu Ala Leu Val Trp 
            100                 105                 110         


Lys Val Leu Gly Lys Leu Gly Met Gln Pro Gly Arg Gln His Ser Ile 
        115                 120                 125             


Phe Gly Asp Pro Lys Lys Ile Val Thr Glu Glu Phe Val Arg Arg Gly 
    130                 135                 140                 


Tyr Leu Ile Tyr Lys Pro Val Pro Arg Ser Ser Pro Val Glu Tyr Glu 
145                 150                 155                 160 


Phe Phe Trp Gly Pro Arg Ala His Val Glu Ser Ser Lys Leu Lys Val 
                165                 170                 175     


Met His Phe Val Ala Arg Val Arg Asn Arg Cys Ser Lys Asp Trp Pro 
            180                 185                 190         


Cys Asn Tyr Asp Trp Asp Ser Asp Asp Asp Ala Glu Val Glu Ala Ile 
        195                 200                 205             


Leu Asn Ser Gly Ala Arg Gly Tyr Ser Ala Pro 
    210                 215                 


<210>  2415
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGE-H1__Homo_sapiens__AAD31314

<400>  2415
augccucggg gacgaaagag ucggcgccgc cguaaugcga gagccgcaga agagaaccgc       60

aacaaucgca aaauccaggc cucagaggcc uccgagaccc cuauggccgc cucuguggua      120

gcgagcaccc ccgaagacga ccugagcggc cccgaggaag acccgagcac uccagaggag      180

gccucuacca ccccugaaga agccucgagc acugcccaag cacaaaagcc uucagugccc      240

cggagcaauu uucagggcac caagaaaagu cuccugaugu cuauauuagc gcucaucuuc      300

aucaugggca acagcgccaa ggaagcucug gucuggaaag ugcuggggaa guuaggaaug      360

cagccuggac gucagcacag caucuuugga gauccgaaga agaucgucac agaagaguuu      420

gugcgcagag gguaccugau uuauaaaccg gugccccgua gcaguccggu ggaguaugag      480

uucuucuggg ggccccgagc acacguggaa ucgagcaaac ugaaagucau gcauuuugug      540

gcaaggguuc guaaccgaug cucuaaagac uggccuugua auuaugacug ggauucggac      600

gaugaugcag agguugaggc uauccucaau ucaggugcua gggguuauuc cgccccuuaa      660


<210>  2416
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGE-H1__Homo_sapiens__AAD31314

<400>  2416
augccccgcg gccgcaagag ccggcggcgc cggaacgccc gcgccgcgga ggagaaccgg       60

aacaaccgca agauccaggc cuccgaggcc agcgagaccc cgauggccgc cuccgugguc      120

gcgagcaccc ccgaggacga ccuguccggg cccgaggagg accccagcac gccggaggag      180

gccuccacca cccccgagga ggccagcucc accgcccagg cgcagaagcc cagcgugccc      240

cgguccaacu uccagggcac gaagaagucc cuccugauga gcauccuggc ccucaucuuc      300

aucaugggga acagcgccaa ggaggcccug guguggaagg uccugggcaa gcucgggaug      360

cagccgggcc gccagcacuc caucuucggc gaccccaaga agaucgugac cgaggaguuc      420

gugcggcgcg gguaccugau cuacaagccc gucccccgga gcuccccggu ggaguacgag      480

uucuucuggg gcccccgcgc ccacguggag agcuccaagc ugaaggucau gcacuucgug      540

gcgcgggugc gcaaccggug cagcaaggac uggcccugca acuacgacug ggacagcgac      600

gacgacgccg aggucgaggc cauccucaac uccggggccc gcggcuacag cgcccccuga      660


<210>  2417
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGE-H1__Homo_sapiens__AAD31314

<400>  2417
augccccgcg gccgcaaguc ccgccgccgc cgcaacgccc gcgccgccga ggagaaccgc       60

aacaaccgca agauccaggc cuccgaggcc uccgagaccc ccauggccgc cuccgucguc      120

gccuccaccc ccgaggacga ccucuccggc cccgaggagg accccuccac ccccgaggag      180

gccuccacca cccccgagga ggccuccucc accgcccagg cccagaagcc cuccgucccc      240

cgcuccaacu uccagggcac caagaagucc cuccucaugu ccauccucgc ccucaucuuc      300

aucaugggca acuccgccaa ggaggcccuc gucuggaagg uccucggcaa gcucggcaug      360

cagcccggcc gccagcacuc caucuucggc gaccccaaga agaucgucac cgaggaguuc      420

guccgccgcg gcuaccucau cuacaagccc gucccccgcu ccucccccgu cgaguacgag      480

uucuucuggg gcccccgcgc ccacgucgag uccuccaagc ucaaggucau gcacuucguc      540

gcccgcgucc gcaaccgcug cuccaaggac uggcccugca acuacgacug ggacuccgac      600

gacgacgccg aggucgaggc cauccucaac uccggcgccc gcggcuacuc cgcccccuga      660


<210>  2418
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGE-H1__Homo_sapiens__AAD31314

<400>  2418
augcccagag gcaggaaguc gcggcgccga cguaacgcca gagcugcaga ggaaaauagg       60

aacaaucgga aaauccaggc cuccgaggcg ucugaaaccc cuauggcugc cucagugguc      120

gcaaguacac cagaggacga ucugagcggg ccggaagagg accccuccac uccugaggaa      180

gccucuacga ccccagagga agcuagcuca acagcacaag cccagaagcc cagcguuccu      240

cgcaguaacu uccagggaac uaaaaagucc cuccuuaugu cuauucuggc uuugauauuu      300

aucaugggua auagcgccaa agaggcguua guguggaagg uacugggcaa gcuagggaug      360

cagccaggaa gacaacacuc cauuuucggc gaucccaaaa agaucgugac cgaggaauuu      420

gucaggcggg guuaccucau uuauaaaccu gugccacgcu caaguccggu ugaguacgag      480

uucuuuuggg ggccccgagc acauguggaa agcucuaagc ugaaagucau gcacuucgug      540

gccagaguaa ggaaccggug cuccaaggac uggccuugua auuaugauug ggacucagau      600

gacgaugcug aaguugaggc cauccuuaac agcggagcac guggcuacag ugcuccauga      660


<210>  2419
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGE-H1__Homo_sapiens__AAD31314

<400>  2419
augcccagag gcagaaagag cagaagaaga agaaacgcca gagccgccga ggagaacaga       60

aacaacagaa agauccaggc cagcgaggcc agcgagaccc ccauggccgc cagcguggug      120

gccagcaccc ccgaggacga ccugagcggc cccgaggagg accccagcac ccccgaggag      180

gccagcacca cccccgagga ggccagcagc accgcccagg cccagaagcc cagcgugccc      240

agaagcaacu uccagggcac caagaagagc cugcugauga gcauccuggc ccugaucuuc      300

aucaugggca acagcgccaa ggaggcccug guguggaagg ugcugggcaa gcugggcaug      360

cagcccggca gacagcacag caucuucggc gaccccaaga agaucgugac cgaggaguuc      420

gugagaagag gcuaccugau cuacaagccc gugcccagaa gcagccccgu ggaguacgag      480

uucuucuggg gccccagagc ccacguggag agcagcaagc ugaaggugau gcacuucgug      540

gccagaguga gaaacagaug cagcaaggac uggcccugca acuacgacug ggacagcgac      600

gacgacgccg agguggaggc cauccugaac agcggcgcca gaggcuacag cgcccccuga      660


<210>  2420
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGE-H1__Homo_sapiens__AAD31314

<400>  2420
augcccagag gccggaaguc ucgcagacgg cgcaacgcca gagcugccga ggaaaaucgg       60

aacaaucgca aaauccaggc guccgaggcu ucugaaaccc cuauggccgc cagcgugguc      120

gcuuccacac cggaggacga ucugucuggg cccgaagagg acccuagcac gcccgaggaa      180

gccuccacca caccugagga agcuagcagc accgcccaag cgcagaagcc cuccguuccu      240

agaagcaacu uccagggaac aaagaagucu cuccugaugu ccauucuugc ccugaucuuu      300

auuaugggca auagcgcuaa agaggcccuc guguggaagg ugcuggggaa acuuggaaug      360

cagccgggcc ggcaacacuc uaucuucggg gaucccaaaa agauugucac cgaggaauuu      420

gugcgcagag gauaccugau cuauaaaccu guuccccggu ccagcccugu ggaguacgag      480

uucuuuuggg gcccccgcgc ucaugucgaa ucuuccaagc ucaaagugau gcacuucguu      540

gccagagugc ggaaccgcug cagcaaggac uggccgugua auuaugauug ggacuccgau      600

gacgaugcgg aagucgaggc cauccugaac ucuggcgcua gaggguacag cgccccuuga      660


<210>  2421
<211>  1249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAGEL2__Homo_sapiens__Q9UJ55

<400>  2421

Met Ser Gln Leu Ser Lys Asn Leu Gly Asp Ser Ser Pro Pro Ala Glu 
1               5                   10                  15      


Ala Pro Lys Pro Pro Val Tyr Ser Arg Pro Thr Val Leu Met Arg Ala 
            20                  25                  30          


Pro Pro Ala Ser Ser Arg Ala Pro Pro Val Pro Trp Asp Pro Pro Pro 
        35                  40                  45              


Ile Asp Leu Gln Ala Ser Leu Ala Ala Trp Gln Ala Pro Gln Pro Ala 
    50                  55                  60                  


Trp Glu Ala Pro Gln Gly Gln Leu Pro Ala Pro Val Val Pro Met Thr 
65                  70                  75                  80  


Gln Pro Pro Ala Leu Gly Gly Pro Ile Val Pro Ala Pro Pro Leu Gly 
                85                  90                  95      


Gly Pro Met Gly Lys Pro Pro Thr Pro Gly Val Leu Met Val His Pro 
            100                 105                 110         


Pro Pro Pro Gly Ala Pro Met Ala Gln Pro Pro Thr Pro Gly Val Leu 
        115                 120                 125             


Met Val His Pro Ser Ala Pro Gly Ala Pro Met Ala His Pro Pro Pro 
    130                 135                 140                 


Pro Gly Thr Pro Met Ser His Pro Pro Pro Pro Gly Thr Pro Met Ala 
145                 150                 155                 160 


His Pro Pro Pro Pro Gly Thr Pro Met Ala His Pro Pro Pro Pro Gly 
                165                 170                 175     


Thr Pro Met Val His Pro Pro Pro Pro Gly Thr Pro Met Ala His Pro 
            180                 185                 190         


Pro Pro Pro Gly Thr Pro Met Ala His Pro Pro Pro Pro Gly Thr Pro 
        195                 200                 205             


Met Ala His Pro Pro Pro Pro Gly Thr Pro Met Ala His Pro Pro Pro 
    210                 215                 220                 


Pro Gly Thr Pro Met Ala Gln Pro Pro Ala Pro Gly Val Leu Met Ala 
225                 230                 235                 240 


Gln Pro Leu Thr Pro Gly Val Leu Met Val Gln Pro Ala Ala Pro Gly 
                245                 250                 255     


Ala Pro Met Val Gln Pro Pro Pro Ala Ala Met Met Thr Gln Pro Gln 
            260                 265                 270         


Pro Ser Gly Ala Pro Met Ala Lys Pro Pro Gly Pro Gly Val Leu Met 
        275                 280                 285             


Ile His Pro Pro Gly Ala Arg Ala Pro Met Thr Gln Pro Pro Ala Ser 
    290                 295                 300                 


Gly Ala Pro Met Ala Gln Pro Ala Ala Pro Pro Ala Gln Pro Met Ala 
305                 310                 315                 320 


Pro Pro Ala Gln Pro Met Ala Ser Trp Ala Pro Gln Ala Gln Pro Leu 
                325                 330                 335     


Ile Leu Gln Ile Gln Ser Gln Val Ile Arg Ala Pro Pro Gln Val Pro 
            340                 345                 350         


Gln Gly Pro Gln Ala Pro Pro Ala Gln Leu Ala Thr Pro Pro Gly Trp 
        355                 360                 365             


Gln Ala Thr Ser Pro Gly Trp Gln Ala Thr Gln Gln Gly Trp Gln Ala 
    370                 375                 380                 


Thr Pro Leu Thr Trp Gln Thr Thr Gln Val Thr Trp Gln Ala Pro Ala 
385                 390                 395                 400 


Val Thr Trp Gln Val Pro Pro Pro Met Arg Gln Gly Pro Pro Pro Ile 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ile Arg Pro Gly Pro Pro Pro Val Arg Gln 
            420                 425                 430         


Ala Pro Pro Leu Ile Arg Gln Ala Pro Pro Val Ile Arg Gln Ala Pro 
        435                 440                 445             


Pro Val Ile Arg Gln Ala Pro Pro Val Ile Arg Gln Ala Pro Ala Val 
    450                 455                 460                 


Ile Arg Gln Ala Pro Pro Val Ile Arg Gln Ala Pro Pro Val Ile Arg 
465                 470                 475                 480 


Gln Ala Pro Pro Val Ile Arg Gln Ala Pro Pro Leu Ile Arg Gln Ala 
                485                 490                 495     


Pro Pro Pro Ile Arg Pro Ala Pro Gln Val Leu Ala Thr Gln Pro Pro 
            500                 505                 510         


Leu Trp Gln Ala Leu Pro Pro Pro Pro Pro Leu Arg Gln Ala Pro Gln 
        515                 520                 525             


Ala Arg Leu Pro Ala Pro Gln Val Gln Ala Ala Pro Gln Val Pro Thr 
    530                 535                 540                 


Ala Pro Pro Ala Thr Gln Val Pro Ala Ala Pro Pro Ala Gly Pro Gln 
545                 550                 555                 560 


Val Pro Gln Pro Val Leu Pro Ala Pro Leu Ser Ala Pro Leu Ser Ala 
                565                 570                 575     


Pro Gln Ala Val His Cys Pro Ser Ile Ile Trp Gln Ala Pro Lys Gly 
            580                 585                 590         


Gln Pro Pro Val Pro His Glu Ile Pro Thr Ser Met Glu Phe Gln Glu 
        595                 600                 605             


Val Gln Gln Thr Gln Ala Leu Ala Trp Gln Ala Gln Lys Ala Pro Thr 
    610                 615                 620                 


His Ile Trp Gln Pro Leu Pro Ala Gln Glu Ala Gln Arg Gln Ala Pro 
625                 630                 635                 640 


Pro Leu Val Gln Leu Glu Gln Pro Phe Gln Gly Ala Pro Pro Ser Gln 
                645                 650                 655     


Lys Ala Val Gln Ile Gln Leu Pro Pro Gln Gln Ala Gln Ala Ser Gly 
            660                 665                 670         


Pro Gln Ala Glu Val Pro Thr Leu Pro Leu Gln Pro Ser Trp Gln Ala 
        675                 680                 685             


Pro Pro Ala Val Leu Gln Ala Gln Pro Gly Pro Pro Val Ala Ala Ala 
    690                 695                 700                 


Asn Phe Pro Leu Gly Ser Ala Lys Ser Leu Met Thr Pro Ser Gly Glu 
705                 710                 715                 720 


Cys Arg Ala Ser Ser Ile Asp Arg Arg Gly Ser Ser Lys Glu Arg Arg 
                725                 730                 735     


Thr Ser Ser Lys Glu Arg Arg Ala Pro Ser Lys Asp Arg Met Ile Phe 
            740                 745                 750         


Ala Ala Thr Phe Cys Ala Pro Lys Ala Val Ser Ala Ala Arg Ala His 
        755                 760                 765             


Leu Pro Ala Ala Trp Lys Asn Leu Pro Ala Thr Pro Glu Thr Phe Ala 
    770                 775                 780                 


Pro Ser Ser Ser Val Phe Pro Ala Thr Ser Gln Phe Gln Pro Ala Ser 
785                 790                 795                 800 


Leu Asn Ala Phe Lys Gly Pro Ser Ala Ala Ser Glu Thr Pro Lys Ser 
                805                 810                 815     


Leu Pro Tyr Ala Leu Gln Asp Pro Phe Ala Cys Val Glu Ala Leu Pro 
            820                 825                 830         


Ala Val Pro Trp Val Pro Gln Pro Asn Met Asn Ala Ser Lys Ala Ser 
        835                 840                 845             


Gln Ala Val Pro Thr Phe Leu Met Ala Thr Ala Ala Ala Pro Gln Ala 
    850                 855                 860                 


Thr Ala Thr Thr Gln Glu Ala Ser Lys Thr Ser Val Glu Pro Pro Arg 
865                 870                 875                 880 


Arg Ser Gly Lys Ala Thr Arg Lys Lys Lys His Leu Glu Ala Gln Glu 
                885                 890                 895     


Asp Ser Arg Gly His Thr Leu Ala Phe His Asp Trp Gln Gly Pro Arg 
            900                 905                 910         


Pro Trp Glu Asn Leu Asn Leu Ser Asp Trp Glu Val Gln Ser Pro Ile 
        915                 920                 925             


Gln Val Ser Gly Asp Trp Glu His Pro Asn Thr Pro Arg Gly Leu Ser 
    930                 935                 940                 


Gly Trp Glu Gly Pro Ser Thr Ser Arg Ile Leu Ser Gly Trp Glu Gly 
945                 950                 955                 960 


Pro Ser Ala Ser Trp Ala Leu Ser Ala Trp Glu Gly Pro Ser Thr Ser 
                965                 970                 975     


Arg Ala Leu Gly Leu Ser Glu Ser Pro Gly Ser Ser Leu Pro Val Val 
            980                 985                 990         


Val Ser Glu Val Ala Ser Val Ser Pro Gly Ser Ser Ala Thr Gln Asp 
        995                 1000                1005            


Asn Ser Lys Val Glu Ala Gln Pro Leu Ser Pro Leu Asp Glu Arg Ala 
    1010                1015                1020                


Asn Ala Leu Val Gln Phe Leu Leu Val Lys Asp Gln Ala Lys Val Pro 
1025                1030                1035                1040


Val Gln Arg Ser Glu Met Val Lys Val Ile Leu Arg Glu Tyr Lys Asp 
                1045                1050                1055    


Glu Cys Leu Asp Ile Ile Asn Arg Ala Asn Asn Lys Leu Glu Cys Ala 
            1060                1065                1070        


Phe Gly Tyr Gln Leu Lys Glu Ile Asp Thr Lys Asn His Ala Tyr Ile 
        1075                1080                1085            


Ile Ile Asn Lys Leu Gly Tyr His Thr Gly Asn Leu Val Ala Ser Tyr 
    1090                1095                1100                


Leu Asp Arg Pro Lys Phe Gly Leu Leu Met Val Val Leu Ser Leu Ile 
1105                1110                1115                1120


Phe Met Lys Gly Asn Cys Val Arg Glu Asp Leu Ile Phe Asn Phe Leu 
                1125                1130                1135    


Phe Lys Leu Gly Leu Asp Val Arg Glu Thr Asn Gly Leu Phe Gly Asn 
            1140                1145                1150        


Thr Lys Lys Leu Ile Thr Glu Val Phe Val Arg Gln Lys Tyr Leu Glu 
        1155                1160                1165            


Tyr Arg Arg Ile Pro Tyr Thr Glu Pro Ala Glu Tyr Glu Phe Leu Trp 
    1170                1175                1180                


Gly Pro Arg Ala Phe Leu Glu Thr Ser Lys Met Leu Val Leu Arg Phe 
1185                1190                1195                1200


Leu Ala Lys Leu His Lys Lys Asp Pro Gln Ser Trp Pro Phe His Tyr 
                1205                1210                1215    


Leu Glu Ala Leu Ala Glu Cys Glu Trp Glu Asp Thr Asp Glu Asp Glu 
            1220                1225                1230        


Pro Asp Thr Gly Asp Ser Ala His Gly Pro Thr Ser Arg Pro Pro Pro 
        1235                1240                1245            


Arg 
    


<210>  2422
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2422
augucgcagc uaaguaagaa ucugggugac ucgaguccuc cggcggaggc cccgaagccg       60

ccugucuaua gccgcccuac gguucugaug cgggccccgc ccgcuuccuc ccgggcuccg      120

ccagucccuu gggauccacc uccaauugac uugcaggcuu cauuggccgc uuggcaggca      180

ccucagccug ccugggaggc cccacagggc cagcugcccg ccccgguggu uccgaugacc      240

cagccuccug cccuaggggg cccgauaguc ccggcucccc cgcugggggg cccgaugggu      300

aagccuccga cucccggggu ccugauggug cauccuccac cuccgggagc cccgauggcc      360

cagccuccga ccccgggagu ccugauggug cauccuucag cucccggagc ucccauggcc      420

cauccuccuc cuccggggac cccaaugucc cacccucccc cuccggggac cccaauggcc      480

cauccuccuc cuccggggac cccgauggcc cauccuccuc cuccggggac cccgauggug      540

cauccuccuc cuccggggac cccgauggcu cauccucccc cuccggggac accgauggcu      600

cauccucccc cuccggggac accgauggcu cauccuccac cuccggggac accgauggcu      660

cauccucccc cuccggguac accgauggcc cagccuccag cuccgggagu ccugauggcc      720

cagccucuga cuccgggagu ccugaugguc cagccugcug cuccgggagc accgaugguc      780

cagccgccuc cagcagccau gaugacccag ccucagccuu caggagcacc gauggccaag      840

ccuccagguc caggaguccu gaugauucau ccuccaggug cgagagcucc gaugacccag      900

ccuccagcuu caggagcacc gauggcacag ccggcggccc caccugcaca gccgauggcc      960

ccaccugcac agccgauggc uucuugggcc ccgcaggcuc agccucugau ccugcaaauc     1020

cagucucaag uuauaagggc uccuccgcag guuccccagg gcccgcaggc acccccagcg     1080

cagcuagcca cacccccggg cuggcaggcg accucgccag gauggcaggc cacgcagcaa     1140

ggcuggcagg ccacuccccu gacuuggcag accacgcagg ucaccuggca ggcaccagcc     1200

guuaccuggc aggugccgcc gcccaugcgc caggggcccc cgcccauccg cccuggccca     1260

ccacccaucc gcccuggccc accaccggug cgacaggccc caccgcugau ccgccaggcc     1320

ccaccgguga uccgccaggc cccacccgug auccgccagg ccccacccgu gauccgccag     1380

gcccccgcug ugauccgcca ggccccaccu gugauccgcc aggccccacc ugugauccgc     1440

caggcuccac cugugauccg ccaggccccg ccgcugaucc gccaggcgcc gccgcccauc     1500

cgaccugccc cacagguccu ggccacccag ccaccgcucu ggcaggcccu gccaccccca     1560

ccuccacugc ggcaggcccc gcaggcuagg cugccggccc cgcaggugca ggcggcgccg     1620

caggugccua cggccccacc ugcuacgcag guacccgcgg cgccgcccgc uggcccgcag     1680

gugccccagc cugugcugcc ggccccgcug ucugccccac ugucugcccc gcaggcugug     1740

cacugcccuu ccaucaucug gcaggccccc aaaggucagc ccccggugcc acacgagauu     1800

ccaacgucaa uggaauucca ggaggugcag cagacacagg cgcuggccug gcaggcccag     1860

aaggccccca cucacaucug gcagccccug ccugcccagg aggcccagag gcaggcuccc     1920

cccuuggucc agcuggagca gcccuuucag ggagccccgc ccucccaaaa agccgugcaa     1980

auccagcuac ccccccagca ggcccaggca ucggguccgc aagcggaggu gcccacacug     2040

ccgcuccagc cuuccuggca ggcaccgccu gcagucuugc aggcccagcc cggacccccg     2100

guagcagcgg caaauuuucc ccugggcucc gcuaaaucau ugaugacucc aucaggagaa     2160

ugcagggccu cuucuauaga ccgcaggggc uccucuaaag agcgcaggac cuccucgaag     2220

gagcgcaggg ccccuucaaa agaccgcaug aucuuugcug ccaccuucug ugcucccaag     2280

gcagugucag cugcgcgagc acaccugcca gcugccugga aaaaccugcc ugccacaccg     2340

gagaccuuug cucccuccuc aagugucuuc ccagcuaccu cccaguuuca gccugccucu     2400

cugaaugccu uuaaaggccc cucugcugcc ucagagaccc caaagucacu gccauaugcu     2460

cugcaggauc ccuuugccug uguagaggcc cugccugcag uuccaugggu cccacagccc     2520

aauaugaaug ccucaaaggc aucgcaggca gugcccaccu uccugauggc uacagcagcu     2580

gccccccagg caacugccac cacucaagag gccuccaaga ccuccgucga gccgccacgc     2640

cgcuccggca aggccacccg gaagaagaag caucuggaag cccaagagga cagccguggc     2700

cacacgcuag ccuuucauga cuggcagggc ccaaggcccu gggagaaucu aaaucugagu     2760

gacugggagg uccaaagccc uauccagguc ucgggugacu gggagcaccc aaacaccccc     2820

cguggccuga gugguuggga gggcccuagc accuccagga uccugagugg cugggaaggg     2880

cccagcgcau ccugggcccu gagugccugg gagggcccga gcaccuccag ggcccugggu     2940

cucucugaaa gcccagggag cucucugccc guaguugugu cugaggucgc aagugucucu     3000

ccgggaucca gugccaccca ggauaauucc aagguggagg cacagcccuu gucucccuug     3060

gaugagaggg caaaugcguu ggugcaguuc cucuuaguca aggaccaagc caaggugccu     3120

guccagcgcu cggagauggu gaaagucauc cuccgagagu auaaagauga gugcuuagau     3180

aucaucaacc gugccaacaa uaagcuggag ugugccuuug guuaucaauu gaaagaaauu     3240

gauaccaaaa accacgccua uauuaucauc aacaagcugg gcuaccauac agggaauuug     3300

guggcauccu auuuagacag gcccaaguuu ggccuucuga ugguggucuu gagccucauc     3360

uuuaugaaag gcaacugugu cagggaggau cugaucuuua auuuucuguu caaguuaggg     3420

uuggaugucc gggagacaaa cggucucuuu ggaaauacua agaagcucau caccgaagug     3480

uuugucaggc agaaguaccu agaguacagg cgaaucccuu acacugagcc cgcagaguau     3540

gaguuccucu ggggcccucg agcauuccug gaaaccagca agaugcuugu ccugagguuu     3600

uuggccaagc uccauaagaa agauccacag agcuggccau uccauuaccu ugaagcgcuc     3660

gcagagugug agugggaaga cacagaugag gaugaaccug acaccgguga cagugcccac     3720

ggccccacca gcaggccccc uccccgcuaa                                      3750


<210>  2423
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2423
augagccagc uguccaagaa ccucggcgac agcucccccc cggccgaggc ccccaagccc       60

cccguguaca gccgcccgac cguccugaug cgggcgcccc ccgccuccag ccgcgccccc      120

ccggugcccu gggacccccc cccgaucgac cugcaggccu cccucgccgc guggcaggcc      180

ccccagcccg ccugggaggc cccccagggg cagcugccgg cgcccguggu ccccaugacc      240

cagcccccgg cccugggcgg gcccaucgug cccgcccccc cgcucggcgg gcccaugggc      300

aagcccccca cgccgggcgu gcugaugguc cacccccccc cgcccggggc ccccauggcc      360

cagcccccga cccccggcgu gcugauggug caccccagcg cgcccggggc cccgauggcc      420

cacccccccc ccccgggcac ccccaugucc cacccccccc cgcccgggac ccccauggcc      480

caccccccgc cccccggcac gcccauggcc cacccgcccc ccccgggcac ccccaugguc      540

cacccccccc cgcccgggac ccccauggcg caccccccgc cccccggcac ccccauggcc      600

cacccgcccc cccccgggac gccgauggcc cacccccccc ccccgggcac ccccauggcc      660

cacccccccc cgcccggcac ccccauggcc cagcccccgg cgcccggggu gcucauggcc      720

cagccccuga ccccgggcgu gcugaugguc cagcccgccg cccccggggc ccccauggug      780

cagccgcccc ccgcggccau gaugacgcag ccccagccga gcggcgcccc cauggccaag      840

ccccccgggc cgggcgugcu caugauccac ccccccggcg cgcgggcccc caugacccag      900

ccgcccgccu ccggggcccc cauggcccag cccgcggccc cgcccgccca gcccauggcc      960

cccccggccc agcccauggc gagcugggcc ccccaggccc agccccugau ccugcagauc     1020

cagucccagg ucauccgcgc cccgccccag gugccccagg gcccgcaggc cccccccgcg     1080

cagcucgcca cccccccggg guggcaggcc accagccccg gcuggcaggc cacgcagcag     1140

ggguggcagg cgaccccccu gaccuggcag accacgcagg ugaccuggca ggcccccgcc     1200

gucaccuggc aggugccgcc ccccaugcgg cagggccccc cgcccauccg ccccggcccc     1260

ccgcccaucc ggcccgggcc cccgcccgug cgccaggccc ccccccugau ccggcaggcc     1320

ccgcccguca uccgccaggc gcccccggug auccggcagg ccccccccgu gauccgccag     1380

gcccccgccg ucauccggca ggccccgccc gugauccgcc aggcgccccc cgucauccgg     1440

caggccccgc ccgugauccg ccaggccccc ccccucaucc ggcaggcccc gccccccauc     1500

cgccccgccc cgcaggugcu ggcgacccag cccccccugu ggcaggcccu ccccccgccc     1560

cccccccugc ggcaggcccc gcaggcccgc cugcccgcgc cccaggucca ggccgccccc     1620

caggugccga cggccccccc cgccacccag gugccggcgg ccccccccgc cggcccccag     1680

gucccgcagc ccgugcuccc cgccccccug uccgccccgc ugagcgcgcc ccaggccgug     1740

cacugccccu ccaucaucug gcaggccccc aaggggcagc cgcccguccc ccacgagauc     1800

cccaccagca uggaguucca ggaggugcag cagacccagg cccucgccug gcaggcgcag     1860

aaggccccga cgcacaucug gcagccccug cccgcccagg aggcccagcg gcaggccccc     1920

ccgcuggugc agcucgagca gcccuuccag ggcgcgcccc ccucccagaa ggccguccag     1980

auccagcugc cgccccagca ggcccaggcc agcgggcccc aggcggaggu gcccacccug     2040

ccgcuccagc ccagcuggca ggcccccccg gccgugcugc aggcccagcc cggccccccc     2100

gucgccgcgg ccaacuuccc gcugggcucc gccaagagcc ucaugacccc cuccggggag     2160

ugccgcgcca gcuccaucga ccgccggggc agcuccaagg agcgccggac cagcuccaag     2220

gagcgccggg cccccagcaa ggaccgcaug aucuucgcgg ccacguucug cgcccccaag     2280

gccguguccg ccgcgcgggc ccaccugccg gccgccugga agaaccugcc cgcgaccccc     2340

gagaccuucg cccccagcuc cagcguguuc ccggccaccu cccaguucca gcccgccagc     2400

cucaacgccu ucaaggggcc cuccgcggcc agcgagacgc ccaagucccu gccguacgcc     2460

cugcaggacc ccuucgccug cgucgaggcc cuccccgcgg ugcccugggu gccgcagccc     2520

aacaugaacg ccagcaaggc cagccaggcc guccccaccu uccugauggc caccgcggcc     2580

gccccccagg ccaccgcgac cacgcaggag gccuccaaga ccagcgugga gccgccccgc     2640

cgguccggca aggccacccg caagaagaag caccuggagg cccaggagga cagccggggc     2700

cacacccucg ccuuccacga cuggcagggg ccccgccccu gggagaaccu gaaccugucc     2760

gacugggagg ugcagagccc gauccagguc uccggcgacu gggagcaccc caacacgccc     2820

cgggggcuca gcggcuggga ggggccgucc accagccgca uccuguccgg cugggagggc     2880

cccagcgcgu ccugggcccu gagcgccugg gaggggcccu ccaccagccg ggcccugggc     2940

cucuccgaga gccccgggag cucccugccg guggugguca gcgagguggc cuccgugagc     3000

cccggcucca gcgcgaccca ggacaacucc aaggucgagg cccagccccu gagcccccuc     3060

gacgagcgcg ccaacgcccu ggugcaguuc cugcucguga aggaccaggc caaggucccg     3120

gugcagcggu ccgagauggu gaaggucauc cugcgcgagu acaaggacga gugccuggac     3180

aucaucaacc gggcgaacaa caagcucgag ugcgccuucg gguaccagcu gaaggagauc     3240

gacacgaaga accacgccua caucaucauc aacaagcugg gcuaccacac cggcaaccuc     3300

guggccagcu accuggaccg ccccaaguuc gggcugcuca uggugguccu gucccugauc     3360

uucaugaagg gcaacugcgu gcgcgaggac cucaucuuca acuuccuguu caagcugggg     3420

cucgacgugc gggagaccaa cggccuguuc gggaacacca agaagcugau cacggagguc     3480

uucgugcgcc agaaguaccu cgaguaccgg cgcauccccu acaccgagcc cgccgaguac     3540

gaguuccugu ggggcccgcg ggcguuccug gagaccagca agaugcucgu gcugcgcuuc     3600

cuggccaagc uccacaagaa ggacccccag uccuggcccu uccacuaccu ggaggcccug     3660

gccgagugcg agugggagga caccgacgag gacgagcccg acacgggcga cagcgcgcac     3720

gggccgaccu cccggccccc cccccgcuga                                      3750


<210>  2424
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2424
augucccagc ucuccaagaa ccucggcgac uccucccccc ccgccgaggc ccccaagccc       60

cccgucuacu cccgccccac cguccucaug cgcgcccccc ccgccuccuc ccgcgccccc      120

cccguccccu gggacccccc ccccaucgac cuccaggccu cccucgccgc cuggcaggcc      180

ccccagcccg ccugggaggc cccccagggc cagcuccccg cccccgucgu ccccaugacc      240

cagccccccg cccucggcgg ccccaucguc cccgcccccc cccucggcgg ccccaugggc      300

aagcccccca cccccggcgu ccucaugguc cacccccccc cccccggcgc ccccauggcc      360

cagcccccca cccccggcgu ccucaugguc caccccuccg cccccggcgc ccccauggcc      420

cacccccccc cccccggcac ccccaugucc cacccccccc cccccggcac ccccauggcc      480

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccaugguc      540

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccauggcc      600

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccauggcc      660

cacccccccc cccccggcac ccccauggcc cagccccccg cccccggcgu ccucauggcc      720

cagccccuca cccccggcgu ccucaugguc cagcccgccg cccccggcgc ccccaugguc      780

cagccccccc ccgccgccau gaugacccag ccccagcccu ccggcgcccc cauggccaag      840

ccccccggcc ccggcguccu caugauccac ccccccggcg cccgcgcccc caugacccag      900

ccccccgccu ccggcgcccc cauggcccag cccgccgccc cccccgccca gcccauggcc      960

ccccccgccc agcccauggc cuccugggcc ccccaggccc agccccucau ccuccagauc     1020

cagucccagg ucauccgcgc ccccccccag gucccccagg gcccccaggc cccccccgcc     1080

cagcucgcca ccccccccgg cuggcaggcc accucccccg gcuggcaggc cacccagcag     1140

ggcuggcagg ccaccccccu caccuggcag accacccagg ucaccuggca ggcccccgcc     1200

gucaccuggc aggucccccc ccccaugcgc cagggccccc cccccauccg ccccggcccc     1260

ccccccaucc gccccggccc cccccccguc cgccaggccc ccccccucau ccgccaggcc     1320

ccccccguca uccgccaggc cccccccguc auccgccagg ccccccccgu cauccgccag     1380

gcccccgccg ucauccgcca ggcccccccc gucauccgcc aggccccccc cgucauccgc     1440

caggcccccc ccgucauccg ccaggccccc ccccucaucc gccaggcccc cccccccauc     1500

cgccccgccc cccagguccu cgccacccag cccccccucu ggcaggcccu cccccccccc     1560

cccccccucc gccaggcccc ccaggcccgc cuccccgccc cccaggucca ggccgccccc     1620

caggucccca ccgccccccc cgccacccag guccccgccg ccccccccgc cggcccccag     1680

gucccccagc ccguccuccc cgccccccuc uccgcccccc ucuccgcccc ccaggccguc     1740

cacugccccu ccaucaucug gcaggccccc aagggccagc cccccguccc ccacgagauc     1800

cccaccucca uggaguucca ggagguccag cagacccagg cccucgccug gcaggcccag     1860

aaggccccca cccacaucug gcagccccuc cccgcccagg aggcccagcg ccaggccccc     1920

ccccucgucc agcucgagca gcccuuccag ggcgcccccc ccucccagaa ggccguccag     1980

auccagcucc ccccccagca ggcccaggcc uccggccccc aggccgaggu ccccacccuc     2040

ccccuccagc ccuccuggca ggcccccccc gccguccucc aggcccagcc cggccccccc     2100

gucgccgccg ccaacuuccc ccucggcucc gccaaguccc ucaugacccc cuccggcgag     2160

ugccgcgccu ccuccaucga ccgccgcggc uccuccaagg agcgccgcac cuccuccaag     2220

gagcgccgcg cccccuccaa ggaccgcaug aucuucgccg ccaccuucug cgcccccaag     2280

gccgucuccg ccgcccgcgc ccaccucccc gccgccugga agaaccuccc cgccaccccc     2340

gagaccuucg cccccuccuc cuccgucuuc cccgccaccu cccaguucca gcccgccucc     2400

cucaacgccu ucaagggccc cuccgccgcc uccgagaccc ccaagucccu ccccuacgcc     2460

cuccaggacc ccuucgccug cgucgaggcc cuccccgccg uccccugggu cccccagccc     2520

aacaugaacg ccuccaaggc cucccaggcc guccccaccu uccucauggc caccgccgcc     2580

gccccccagg ccaccgccac cacccaggag gccuccaaga ccuccgucga gcccccccgc     2640

cgcuccggca aggccacccg caagaagaag caccucgagg cccaggagga cucccgcggc     2700

cacacccucg ccuuccacga cuggcagggc ccccgccccu gggagaaccu caaccucucc     2760

gacugggagg uccagucccc cauccagguc uccggcgacu gggagcaccc caacaccccc     2820

cgcggccucu ccggcuggga gggccccucc accucccgca uccucuccgg cugggagggc     2880

cccuccgccu ccugggcccu cuccgccugg gagggccccu ccaccucccg cgcccucggc     2940

cucuccgagu cccccggcuc cucccucccc gucgucgucu ccgaggucgc cuccgucucc     3000

cccggcuccu ccgccaccca ggacaacucc aaggucgagg cccagccccu cuccccccuc     3060

gacgagcgcg ccaacgcccu cguccaguuc cuccucguca aggaccaggc caaggucccc     3120

guccagcgcu ccgagauggu caaggucauc cuccgcgagu acaaggacga gugccucgac     3180

aucaucaacc gcgccaacaa caagcucgag ugcgccuucg gcuaccagcu caaggagauc     3240

gacaccaaga accacgccua caucaucauc aacaagcucg gcuaccacac cggcaaccuc     3300

gucgccuccu accucgaccg ccccaaguuc ggccuccuca uggucguccu cucccucauc     3360

uucaugaagg gcaacugcgu ccgcgaggac cucaucuuca acuuccucuu caagcucggc     3420

cucgacgucc gcgagaccaa cggccucuuc ggcaacacca agaagcucau caccgagguc     3480

uucguccgcc agaaguaccu cgaguaccgc cgcauccccu acaccgagcc cgccgaguac     3540

gaguuccucu ggggcccccg cgccuuccuc gagaccucca agaugcucgu ccuccgcuuc     3600

cucgccaagc uccacaagaa ggacccccag uccuggcccu uccacuaccu cgaggcccuc     3660

gccgagugcg agugggagga caccgacgag gacgagcccg acaccggcga cuccgcccac     3720

ggccccaccu cccgcccccc cccccgcuga                                      3750


<210>  2425
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2425
augagccagc uguccaagaa ccucggcgac ucuucacccc cugccgaggc uccaaaaccg       60

cccguguaca guagaccuac cguccuuaug agggcaccac ccgccagcuc ccgggcgccu      120

ccaguucccu gggauccucc accgaucgac cugcaggcuu cuuuggccgc auggcaagcu      180

ccccagccug ccugggaagc accacagggg caauuacccg ccccuguggu accaaugaca      240

cagcccccgg cucugggagg uccuauugug cccgccccac cucuaggcgg gcccauggga      300

aagccaccca cuccuggcgu ccucauggug cacccaccgc ccccuggugc gccaauggca      360

cagcccccua cgccaggggu ucugauggug caucccucgg ccccgggagc uccuauggcc      420

cacccacccc cucccggcac cccaauguca cauccucccc caccgggcac accuauggca      480

cacccaccac ccccugggac uccaauggcu caucccccuc cgccaggaac ccccaugguc      540

cacccuccac ccccugguac accgauggcc caucccccac cucccggcac cccaauggcg      600

cacccucccc caccggggac uccuauggcc cacccaccac ccccuggaac accaauggca      660

caucccccuc cgccaggcac ccccauggcu cagccucccg ccccaggugu gcuuauggcu      720

caaccucuga cgcccggggu auugaugguu cagccagccg caccuggagc cccgauggug      780

cagcccccuc ccgcugcgau gaugacucag ccccaaccaa gcggcgcacc uauggccaaa      840

cccccgggcc cagggguccu caugauacac ccucccggag cucgcgcccc aaugacccag      900

cccccugcaa guggugcccc gauggcucag cccgccgcac ccccugcgca acccauggcu      960

ccuccagccc agcccauggc auccugggcc ccucaggcuc agccacugau ccugcaaauu     1020

cagucucagg ugauccgagc cccgccccag gugccucaag gcccacaggc acccccugcu     1080

cagcucgcca caccacccgg guggcaggcg acuagcccgg gauggcaagc cacccagcag     1140

ggcuggcagg cuacaccuuu aaccuggcaa acgacucagg ucacauggca ggcacccgcc     1200

guuaccuggc aagugccacc ucccaugcgu caggguccac ccccuauuag accagggccg     1260

cccccuauca ggccaggacc cccuccagua cggcaggcuc ccccucugau acgccaggcc     1320

ccgccaguga ucagacaagc acccccuguc auuaggcagg cgcccccagu gauccggcag     1380

gccccugcug uuauucgcca ggcaccccca gugauccgac aagccccgcc ugucauaaga     1440

caggcucccc cagugauuag gcaggcaccc ccucuuaucc ggcaggcccc acccccuauu     1500

cguccggccc cacaaguauu ggcuacucag cccccucugu ggcaggcgcu accacccccu     1560

cccccacucc gccaagcccc gcaggcaaga cugccugcuc cccagguuca ggccgcccca     1620

caagugccua cagcuccccc agcaacccag gucccugccg cgcccccggc uggcccacag     1680

gugccucagc ccguccuucc agcaccccug uccgccccuu ugucagcccc gcaagcugug     1740

cacugcccaa guaucaucug gcaggcaccc aagggccagc cucccguucc acaugagauu     1800

ccuacgagca uggaguucca ggaagugcaa cagacccagg cccucgcgug gcaggcucaa     1860

aaagccccca cacacauaug gcagccacug ccugcacagg aagcccaaag gcaggcuccg     1920

cccuuaguac agcuggagca gccauuucaa ggggccccuc ccucucagaa ggcaguccag     1980

auccagcucc caccucaaca ggcucaggcc uccggacccc aggcggaggu gccgacucuu     2040

ccacugcaac cuucauggca ggcaccccca gccguuuugc aggcucaacc cgguccuccc     2100

guggccgcug caaauuuccc acuaggcagc gccaagaguc ugaugacccc uucuggggaa     2160

ugucgggccu ccagcauuga ucgacgcgga ucgucuaaag agagaaggac auccucaaag     2220

gaacggcgcg cuccgaguaa agacagaaug aucuuugcgg caacuuucug cgcccccaag     2280

gcugucagcg ccgcaagggc ccaucuccca gcugcgugga aaaaccugcc ugccaccccc     2340

gagacauuug caccauccuc uagcguguuc ccugcuaccu cacaguuuca gcccgccagu     2400

cuuaaugcau ucaagggccc guccgccgcu agcgagacuc cuaagucucu gccauaugcc     2460

uugcaggauc ccuuugcgug uguagaagca cucccugccg ugccaugggu uccccaaccu     2520

aacaugaaug cuucaaaagc cagucaggcu gucccaacgu uccugauggc aacagccgcu     2580

gcaccccagg ccaccgcgac uacccaggag gccagcaaga cauccgugga accgccucgu     2640

cggucuggua aagcuacccg aaagaaaaag cacuuagagg cccaagaaga cucgagaggg     2700

cauacucugg cauuucacga uuggcagggc cccaggccau gggagaaccu aaaucucagc     2760

gacugggagg ugcagucccc cauacagguc ucaggagauu gggaacaccc uaacacacca     2820

cgcggccuga guggguggga gggacccucu acgagccgga uucuuuccgg uugggaaggc     2880

ccuucagcua gcugggccuu gucugcaugg gaggggccau ccaccaguag agcccuggga     2940

cucagcgaau cuccgggcuc cucacugccc guugugguga gugagguagc uagcgucucg     3000

ccugguuccu cugcgacuca agacaauagc aaaguggagg cccagccacu uucaccccug     3060

gaugaaaggg caaacgcuuu gguucaguuc cuccugguga aggaccaggc caaggucccu     3120

gugcaacgca gugagauggu uaaagugauc uuacgagaau acaaggauga gugccuggac     3180

aucauuaauc gggccaacaa uaaacuagaa ugugcauuug gguaucagcu caaggagauc     3240

gacaccaaaa accaugcuua cauuauaauc aauaagcugg gcuaucacac aggaaaccuu     3300

guagccuccu acuuggaucg uccaaaguuc ggccugcuca uggucgugcu gucuuuaauu     3360

uucaugaaag ggaacugcgu gagagaggac cugaucuuua auuuccuuuu uaaguuggga     3420

cucgauguca gggaaacaaa cggccuguuc gguaauacua aaaagcuaau caccgagguu     3480

uuugugcgcc agaaauaucu ggaauaccgg aggauucccu acacggagcc ggcggaguau     3540

gaguuccucu gggggccuag agcuuuucug gaaaccagca agaugcuugu auugcgauuc     3600

cuggccaagu uacauaaaaa ggacccacaa uccuggcccu uucacuaccu cgaagcacug     3660

gccgagugug aaugggagga uacagacgag gaugaaccug acacuggaga uucagcucac     3720

ggccccacca gccgcccacc gccucgguga                                      3750


<210>  2426
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2426
augagccagc ugagcaagaa ccugggcgac agcagccccc ccgccgaggc ccccaagccc       60

cccguguaca gcagacccac cgugcugaug agagcccccc ccgccagcag cagagccccc      120

cccgugcccu gggacccccc ccccaucgac cugcaggcca gccuggccgc cuggcaggcc      180

ccccagcccg ccugggaggc cccccagggc cagcugcccg cccccguggu gcccaugacc      240

cagccccccg cccugggcgg ccccaucgug cccgcccccc cccugggcgg ccccaugggc      300

aagcccccca cccccggcgu gcugauggug cacccccccc cccccggcgc ccccauggcc      360

cagcccccca cccccggcgu gcugauggug caccccagcg cccccggcgc ccccauggcc      420

cacccccccc cccccggcac ccccaugagc cacccccccc cccccggcac ccccauggcc      480

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccauggug      540

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccauggcc      600

cacccccccc cccccggcac ccccauggcc cacccccccc cccccggcac ccccauggcc      660

cacccccccc cccccggcac ccccauggcc cagccccccg cccccggcgu gcugauggcc      720

cagccccuga cccccggcgu gcugauggug cagcccgccg cccccggcgc ccccauggug      780

cagccccccc ccgccgccau gaugacccag ccccagccca gcggcgcccc cauggccaag      840

ccccccggcc ccggcgugcu gaugauccac ccccccggcg ccagagcccc caugacccag      900

ccccccgcca gcggcgcccc cauggcccag cccgccgccc cccccgccca gcccauggcc      960

ccccccgccc agcccauggc cagcugggcc ccccaggccc agccccugau ccugcagauc     1020

cagagccagg ugaucagagc ccccccccag gugccccagg gcccccaggc cccccccgcc     1080

cagcuggcca ccccccccgg cuggcaggcc accagccccg gcuggcaggc cacccagcag     1140

ggcuggcagg ccaccccccu gaccuggcag accacccagg ugaccuggca ggcccccgcc     1200

gugaccuggc aggugccccc ccccaugaga cagggccccc cccccaucag acccggcccc     1260

ccccccauca gacccggccc cccccccgug agacaggccc ccccccugau cagacaggcc     1320

ccccccguga ucagacaggc cccccccgug aucagacagg ccccccccgu gaucagacag     1380

gcccccgccg ugaucagaca ggcccccccc gugaucagac aggccccccc cgugaucaga     1440

caggcccccc ccgugaucag acaggccccc ccccugauca gacaggcccc cccccccauc     1500

agacccgccc cccaggugcu ggccacccag cccccccugu ggcaggcccu gccccccccc     1560

cccccccuga gacaggcccc ccaggccaga cugcccgccc cccaggugca ggccgccccc     1620

caggugccca ccgccccccc cgccacccag gugcccgccg ccccccccgc cggcccccag     1680

gugccccagc ccgugcugcc cgccccccug agcgcccccc ugagcgcccc ccaggccgug     1740

cacugcccca gcaucaucug gcaggccccc aagggccagc cccccgugcc ccacgagauc     1800

cccaccagca uggaguucca ggaggugcag cagacccagg cccuggccug gcaggcccag     1860

aaggccccca cccacaucug gcagccccug cccgcccagg aggcccagag acaggccccc     1920

ccccuggugc agcuggagca gcccuuccag ggcgcccccc ccagccagaa ggccgugcag     1980

auccagcugc ccccccagca ggcccaggcc agcggccccc aggccgaggu gcccacccug     2040

ccccugcagc ccagcuggca ggcccccccc gccgugcugc aggcccagcc cggccccccc     2100

guggccgccg ccaacuuccc ccugggcagc gccaagagcc ugaugacccc cagcggcgag     2160

ugcagagcca gcagcaucga cagaagaggc agcagcaagg agagaagaac cagcagcaag     2220

gagagaagag cccccagcaa ggacagaaug aucuucgccg ccaccuucug cgcccccaag     2280

gccgugagcg ccgccagagc ccaccugccc gccgccugga agaaccugcc cgccaccccc     2340

gagaccuucg cccccagcag cagcguguuc cccgccacca gccaguucca gcccgccagc     2400

cugaacgccu ucaagggccc cagcgccgcc agcgagaccc ccaagagccu gcccuacgcc     2460

cugcaggacc ccuucgccug cguggaggcc cugcccgccg ugcccugggu gccccagccc     2520

aacaugaacg ccagcaaggc cagccaggcc gugcccaccu uccugauggc caccgccgcc     2580

gccccccagg ccaccgccac cacccaggag gccagcaaga ccagcgugga gccccccaga     2640

agaagcggca aggccaccag aaagaagaag caccuggagg cccaggagga cagcagaggc     2700

cacacccugg ccuuccacga cuggcagggc cccagacccu gggagaaccu gaaccugagc     2760

gacugggagg ugcagagccc cauccaggug agcggcgacu gggagcaccc caacaccccc     2820

agaggccuga gcggcuggga gggccccagc accagcagaa uccugagcgg cugggagggc     2880

cccagcgcca gcugggcccu gagcgccugg gagggcccca gcaccagcag agcccugggc     2940

cugagcgaga gccccggcag cagccugccc guggugguga gcgagguggc cagcgugagc     3000

cccggcagca gcgccaccca ggacaacagc aagguggagg cccagccccu gagcccccug     3060

gacgagagag ccaacgcccu ggugcaguuc cugcugguga aggaccaggc caaggugccc     3120

gugcagagaa gcgagauggu gaaggugauc cugagagagu acaaggacga gugccuggac     3180

aucaucaaca gagccaacaa caagcuggag ugcgccuucg gcuaccagcu gaaggagauc     3240

gacaccaaga accacgccua caucaucauc aacaagcugg gcuaccacac cggcaaccug     3300

guggccagcu accuggacag acccaaguuc ggccugcuga ugguggugcu gagccugauc     3360

uucaugaagg gcaacugcgu gagagaggac cugaucuuca acuuccuguu caagcugggc     3420

cuggacguga gagagaccaa cggccuguuc ggcaacacca agaagcugau caccgaggug     3480

uucgugagac agaaguaccu ggaguacaga agaauccccu acaccgagcc cgccgaguac     3540

gaguuccugu ggggccccag agccuuccug gagaccagca agaugcuggu gcugagauuc     3600

cuggccaagc ugcacaagaa ggacccccag agcuggcccu uccacuaccu ggaggcccug     3660

gccgagugcg agugggagga caccgacgag gacgagcccg acaccggcga cagcgcccac     3720

ggccccacca gcagaccccc ccccagauga                                      3750


<210>  2427
<211>  3750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MAGEL2__Homo_sapiens__CCDS73700.1

<400>  2427
augagccagc uguccaagaa ccucggcgac ucuagcccgc cugccgaggc uccgaaaccc       60

ccuguguacu ccagacccac cguccugaug cgggccccuc ccgcgucuag ccgcgcuccu      120

ccgguucccu gggauccucc cccuaucgac cuucaagccu cccuggccgc uuggcaggcg      180

ccccagccgg cuugggaagc cccucagggg caacuccccg cgccuguggu gcccaugaca      240

cagcccccug cccugggagg cccgauuguc cccgcuccuc cccuuggggg accuaugggc      300

aagcccccga cgccuggggu gcugaugguu caucccccuc ccccuggagc ccccauggcu      360

cagccgccua cccccggcgu gcucaugguc caccccucug ccccuggcgc gccgauggcc      420

caucccccuc ccccugggac acccaugagc cacccucccc cgccuggaac ccccauggcu      480

cacccucccc cgccuggcac acccauggcc cauccuccuc cgcccgggac ccccauggug      540

caucccccuc ccccuggaac acccauggcu cacccuccgc ccccuggcac ccccauggcc      600

cacccucccc cgccugggac gcccauggcc caucccccuc ccccuggaac cccgauggcu      660

caucccccuc ccccuggcac acccauggcg cagccgccug cccccggcgu ucugauggcu      720

caaccucuga cccccggggu gcucaugguc cagccugccg cccccggagc uccgauggug      780

cagccuccuc ccgccgcgau gaugacacag ccccaaccgu ccggcgcucc cauggccaaa      840

ccucccgggc cuggagugcu gaugauccau cccccuggcg ccagagcucc gaugacccag      900

cccccugcca gcggggcucc cauggcccag ccugcggcuc ccccggccca accuauggcc      960

ccucccgcuc agcccauggc cucuugggcg ccccaggccc agccucuuau ucugcaaauc     1020

cagucccagg ucauucgggc uccgccccag guuccucaag gaccccaggc cccucccgcu     1080

cagcucgcca cgccgccugg cuggcaggcc acaagccccg gcuggcaagc uacccagcag     1140

ggguggcagg cgacaccucu gaccuggcaa accacacagg ugacguggca ggcccccgcu     1200

gugaccuggc aagucccucc cccgaugcgc cagggaccuc cucccaucag acccggcccg     1260

cccccuaucc ggcccgggcc ucccccugug cgccaggcuc ccccgcuuau uagacaggcc     1320

ccucccguua uccggcaagc cccucccgug auucgccagg ccccgccugu caucagacag     1380

gcgcccgcug ugauucggca ggcucccccu guuauccgcc aagcgccccc ugugauuaga     1440

caggccccgc ccgucauccg gcaggccccu ccccugaucc gccaggcccc ucccccuauu     1500

agaccggcuc cccaagugcu cgccacacag ccuccccugu ggcaggcccu gccucccccg     1560

ccuccccucc ggcaagcucc ccaggccaga cugccugcuc cccaggucca ggccgcgccu     1620

caagugccga ccgcuccccc ugccacacag guucccgccg cuccucccgc cggaccccag     1680

gugccucagc ccguccuucc ugcuccccug ucugccccgc ucuccgcgcc ucaagccgug     1740

cacugcccca gcaucauuug gcaggcuccc aagggccagc cucccguucc ucacgagauc     1800

ccgaccucua uggaguucca ggaagugcaa cagacgcagg cccuggccug gcaggcucaa     1860

aaagccccca cacacauuug gcagccucuu cccgcgcagg aagcucaacg ccaggccccu     1920

ccccuggucc agcucgagca gccuuuucaa ggggccccgc ccucccagaa ggcugugcag     1980

auccagcugc cuccccaaca ggcccaggcg agcggcccuc aggcugaggu gcccacccug     2040

ccgcuccaac cuuccuggca ggccccuccc gccguucugc aggcucaacc cggacccccu     2100

gucgccgcug ccaauuuccc gcuuggcucu gccaagagcc ugaugacccc cuccggggaa     2160

ugucgggcca gcucuaucga uagacgcgga uccagcaaag agcggagaac aucuagcaag     2220

gaacgccggg cuccuuccaa agacagaaug auuuuugccg cuaccuucug cgcccccaag     2280

gccgugucug cugcgcgcgc ccaccucccu gcugccugga aaaaccugcc cgccacaccg     2340

gagacguuug cuccuagcuc cagcguguuc cccgccaccu cucaguuuca gccugcgucc     2400

cuuaaugcuu ucaagggccc cagcgccgcc ucugagacac cuaagucccu gcccuaugcu     2460

cuccaggauc cguuugccug ugucgaagcg cugcccgccg ugccuugggu uccccaaccu     2520

aacaugaaug cuagcaaagc cucccaggcu gugccgaccu uccugauggc cacagcugcc     2580

gcgccccagg ccaccgcuac gacccaggag gccucuaaga caagcgucga accuccccgg     2640

agauccggga aagcuacccg caagaaaaag caccucgagg cccaagaaga cucucgggga     2700

cauacacugg ccuuucacga uuggcagggc ccuagacccu gggagaaccu uaaucugagc     2760

gacugggagg ugcagucccc uauccagguu agcggggauu gggaacaccc caacaccccg     2820

cggggccucu cuggauggga gggcccuucc acgagccgca uucugucugg gugggaagga     2880

cccuccgcua gcugggcgcu gucugccugg gagggcccua gcacauccag agcucuuggg     2940

cucagcgaau cucccggauc cagccugccg guggucgugu ccgagguugc cucugugagc     3000

ccuggcuccu cugccaccca agacaauagc aaagucgagg cucagccccu gucuccccuc     3060

gaugaacggg ccaacgcgcu ggugcaguuc cuucugguga aggaccaggc caaggucccu     3120

guucaaagau ccgagauggu gaaagugauc cuccgcgaau acaaggauga gugccuggac     3180

auuaucaauc gggcuaacaa uaaacuggaa ugugccuuug gguaucagcu uaaggagauc     3240

gacaccaaaa accaugcuua cauuaucauu aauaagcucg gcuaucacac aggaaaccug     3300

gucgccagcu accuggauag acccaaguuc ggccuccuga uggugguucu uucccugauc     3360

uucaugaaag ggaacugcgu gcgcgaggac cucauuuuua auuuccuguu uaagcuggga     3420

cuugauguca gagaaaccaa cggccucuuc gggaauacga aaaagcugau cacagaggug     3480

uuuguucggc agaaauaucu ggaauaccgc cggauuccuu acaccgagcc ggcggaguau     3540

gaguuccucu ggggacccag agccuuucug gaaacaagca agaugcuugu gcugcgcuuc     3600

cucgcuaagc ugcauaaaaa ggacccucaa ucuuggcccu uucacuaccu ggaagcccuu     3660

gcugagugug aaugggagga uaccgacgag gaugaaccug acacaggcga uuccgcccac     3720

gggcccacca gcagaccgcc uccccgguga                                      3750


<210>  2428
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  mammaglobin_A__Homo_sapiens__Q13296

<400>  2428

Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Ser Gln His Cys 
1               5                   10                  15      


Tyr Ala Gly Ser Gly Cys Pro Leu Leu Glu Asn Val Ile Ser Lys Thr 
            20                  25                  30          


Ile Asn Pro Gln Val Ser Lys Thr Glu Tyr Lys Glu Leu Leu Gln Glu 
        35                  40                  45              


Phe Ile Asp Asp Asn Ala Thr Thr Asn Ala Ile Asp Glu Leu Lys Glu 
    50                  55                  60                  


Cys Phe Leu Asn Gln Thr Asp Glu Thr Leu Ser Asn Val Glu Val Phe 
65                  70                  75                  80  


Met Gln Leu Ile Tyr Asp Ser Ser Leu Cys Asp Leu Phe 
                85                  90              


<210>  2429
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  mammaglobin_A__Homo_sapiens__AAC39608

<400>  2429
augaaguugc ugaugguccu caugcuggcg gcccucuccc agcacugcua cgcaggcucu       60

ggcugccccu uauuggagaa ugugauuucc aagacaauca auccacaagu gucuaagacu      120

gaauacaaag aacuucuuca agaguucaua gacgacaaug ccacuacaaa ugccauagau      180

gaauugaagg aauguuuucu uaaccaaacg gaugaaacuc ugagcaaugu ugagguguuu      240

augcaauuaa uauaugacag cagucuuugu gauuuauuuu aa                         282


<210>  2430
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       mammaglobin_A__Homo_sapiens__AAC39608

<400>  2430
augaagcugc ucauggugcu gaugcuggcc gcccucagcc agcacugcua cgcgggcucc       60

gggugcccgc ugcuggagaa cgucaucagc aagaccauca acccccaggu guccaagacc      120

gaguacaagg agcuccugca ggaguucauc gacgacaacg ccacgaccaa cgccaucgac      180

gagcugaagg agugcuuccu caaccagacc gacgagaccc ugagcaacgu ggaggucuuc      240

augcagcuga ucuacgacuc cagccucugc gaccuguucu ga                         282


<210>  2431
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       mammaglobin_A__Homo_sapiens__AAC39608

<400>  2431
augaagcucc ucaugguccu caugcucgcc gcccucuccc agcacugcua cgccggcucc       60

ggcugccccc uccucgagaa cgucaucucc aagaccauca acccccaggu cuccaagacc      120

gaguacaagg agcuccucca ggaguucauc gacgacaacg ccaccaccaa cgccaucgac      180

gagcucaagg agugcuuccu caaccagacc gacgagaccc ucuccaacgu cgaggucuuc      240

augcagcuca ucuacgacuc cucccucugc gaccucuucu ga                         282


<210>  2432
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       mammaglobin_A__Homo_sapiens__AAC39608

<400>  2432
augaagcugc ucauggugcu uaugcuggcc gcuuugagcc agcacugcua cgcaggcucc       60

gggugucccu uacuggagaa cgucaucucu aaaaccauua auccucaagu uucaaagaca      120

gaauauaaag agcuacucca ggaguucaua gacgauaacg ccacuacgaa ugcgaucgac      180

gaacugaagg aaugcuuucu uaaccagacc gaugagacac ugaguaaugu ggagguauuc      240

augcaguuga uuuacgacag cucccucugu gaucuguuuu ga                         282


<210>  2433
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       mammaglobin_A__Homo_sapiens__AAC39608

<400>  2433
augaagcugc ugauggugcu gaugcuggcc gcccugagcc agcacugcua cgccggcagc       60

ggcugccccc ugcuggagaa cgugaucagc aagaccauca acccccaggu gagcaagacc      120

gaguacaagg agcugcugca ggaguucauc gacgacaacg ccaccaccaa cgccaucgac      180

gagcugaagg agugcuuccu gaaccagacc gacgagaccc ugagcaacgu ggagguguuc      240

augcagcuga ucuacgacag cagccugugc gaccuguucu ga                         282


<210>  2434
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       mammaglobin_A__Homo_sapiens__AAC39608

<400>  2434
augaagcugc ucauggugcu gaugcuugcc gcucugagcc agcacugcua cgccggcucc       60

gggugucccc uccuggagaa cgucaucucu aaaaccauua auccucaagu uagcaagaca      120

gaauauaaag agcuucugca ggaauuuauc gacgauaacg cgacgaccaa ugcuauugac      180

gagcucaagg aaugcuuucu gaaccagaca gaugagaccc uguccaaugu ggagguguuc      240

augcagcuca ucuacgacuc uagccugugu gaucuuuucu ga                         282


<210>  2435
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  mammaglobin_A__Homo_sapiens__Q6NX70

<400>  2435

Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Ser Gln His Cys 
1               5                   10                  15      


Tyr Ala Gly Ser Gly Cys Pro Leu Leu Glu Asn Val Ile Ser Lys Thr 
            20                  25                  30          


Ile Asn Pro Gln Val Ser Lys Thr Glu Tyr Lys Glu Leu Leu Gln Glu 
        35                  40                  45              


Phe Ile Asp Asp Asn Ala Thr Thr Asn Ala Ile Asp Glu Leu Lys Glu 
    50                  55                  60                  


Cys Phe Leu Asn Gln Thr Asp Glu Thr Leu Ser Asn Val Glu Val Phe 
65                  70                  75                  80  


Met Val Ile Ser Phe Ser Ser Tyr Lys Leu Phe Lys Ser Pro Asp Gln 
                85                  90                  95      


Gly Gln Val Gly Ser Ser Phe Leu Thr Asp Asn Ala Lys Ala Thr Ser 
            100                 105                 110         


Glu Gln Ala Phe Ser Tyr Ile Gly 
        115                 120 


<210>  2436
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  mammaglobin_A__Homo_sapiens__AAH67220

<400>  2436
augaaguugc ugaugguccu caugcuggcg gcccucuccc agcacugcua cgcaggcucu       60

ggcugccccu uauuggagaa ugugauuucc aagacaauca auccacaagu gucuaagacu      120

gaauacaaag aacuucuuca agaguucaua gacgacaaug ccacuacaaa ugccauagau      180

gaauugaagg aauguuuucu uaaccaaacg gaugaaacuc ugagcaaugu ugagguguuu      240

augguaauuu cauuuucuuc cuauaagcuu uuuaaauccc cugaccaggg acaagugggc      300

ucuucauuuc ucacugacaa ugccaaagcc acuagugaac aagccuuuuc uuacauuggu      360

uaa                                                                    363


<210>  2437
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       mammaglobin_A__Homo_sapiens__AAH67220

<400>  2437
augaagcugc ucauggugcu gaugcuggcc gcccucagcc agcacugcua cgcgggcucc       60

gggugccccc ugcuggagaa cgucaucagc aagaccauca acccccaggu guccaagacc      120

gaguacaagg agcuccugca ggaguucauc gacgacaacg ccacgaccaa cgccaucgac      180

gagcugaagg agugcuuccu caaccagacc gacgagaccc ugagcaacgu ggaggucuuc      240

auggugaucu ccuucagcuc cuacaagcug uucaagagcc cggaccaggg ccaggugggg      300

uccagcuucc ucacggacaa cgccaaggcc accuccgagc aggcguucag cuacaucggc      360

uga                                                                    363


<210>  2438
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       mammaglobin_A__Homo_sapiens__AAH67220

<400>  2438
augaagcucc ucaugguccu caugcucgcc gcccucuccc agcacugcua cgccggcucc       60

ggcugccccc uccucgagaa cgucaucucc aagaccauca acccccaggu cuccaagacc      120

gaguacaagg agcuccucca ggaguucauc gacgacaacg ccaccaccaa cgccaucgac      180

gagcucaagg agugcuuccu caaccagacc gacgagaccc ucuccaacgu cgaggucuuc      240

auggucaucu ccuucuccuc cuacaagcuc uucaaguccc ccgaccaggg ccaggucggc      300

uccuccuucc ucaccgacaa cgccaaggcc accuccgagc aggccuucuc cuacaucggc      360

uga                                                                    363


<210>  2439
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       mammaglobin_A__Homo_sapiens__AAH67220

<400>  2439
augaagcugc ucauggugcu uaugcuggcc gcuuugagcc agcacugcua cgcaggcucc       60

gggugucccu uacuggagaa cgucaucucu aaaaccauua auccucaagu uucaaagaca      120

gaauauaaag agcuacucca ggaguucaua gacgauaacg ccacuacgaa ugcgaucgac      180

gaacugaagg aaugcuuucu uaaccagacc gaugagacac ugaguaaugu ggagguauuc      240

auggugauua gcuuuuccuc uuacaaauug uucaagucgc cagaccaggg acaagucggu      300

agcucauuuc ucacugauaa cgcuaaggcc accagugaac aggcauucuc cuauaucggc      360

uga                                                                    363


<210>  2440
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       mammaglobin_A__Homo_sapiens__AAH67220

<400>  2440
augaagcugc ugauggugcu gaugcuggcc gcccugagcc agcacugcua cgccggcagc       60

ggcugccccc ugcuggagaa cgugaucagc aagaccauca acccccaggu gagcaagacc      120

gaguacaagg agcugcugca ggaguucauc gacgacaacg ccaccaccaa cgccaucgac      180

gagcugaagg agugcuuccu gaaccagacc gacgagaccc ugagcaacgu ggagguguuc      240

auggugauca gcuucagcag cuacaagcug uucaagagcc ccgaccaggg ccaggugggc      300

agcagcuucc ugaccgacaa cgccaaggcc accagcgagc aggccuucag cuacaucggc      360

uga                                                                    363


<210>  2441
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       mammaglobin_A__Homo_sapiens__AAH67220

<400>  2441
augaagcugc ucauggugcu gaugcuugcc gcucugagcc agcacugcua cgccggcucc       60

gggugucccc uccuggagaa cgucaucucu aaaaccauua auccucaagu uagcaagaca      120

gaauauaaag agcuucugca ggaguucauc gacgauaacg cgacgaccaa ugcuauugac      180

gaacucaagg aaugcuuucu gaaccagaca gaugagaccc uguccaaugu ggagguguuc      240

auggucaucu cuuuuagcuc cuacaaacuc uucaagucuc cggaccaggg acaagugggc      300

agcuccuuuc ugacagauaa cgccaaggcc accagcgaac aggcuuucuc uuauauuggg      360

uga                                                                    363


<210>  2442
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MART-1/melan-A__Homo_sapiens__Q16655

<400>  2442

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  2443
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2443
augccaagag aagaugcuca cuucaucuau gguuacccca agaaggggca cggccacucu       60

uacaccacgg cugaagaggc cgcugggauc ggcauccuga cagugauccu gggagucuua      120

cugcucaucg gcuguuggua uuguagaaga cgaaauggau acagagccuu gauggauaaa      180

agucuucaug uuggcacuca augugccuua acaagaagau gcccacaaga aggguuugau      240

caucgggaca gcaaaguguc ucuucaagag aaaaacugug aaccuguggu ucccaaugcu      300

ccaccugcuu augagaaacu cucugcagaa cagucaccac caccuuauuc accuuaa         357


<210>  2444
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2444
augccccgcg aggacgccca cuucaucuac ggcuacccca agaaggggca cggccacagc       60

uacaccaccg ccgaggaggc ggccgggauc ggcauccuga cggugauccu cgggguccug      120

cugcucaucg gcugcuggua cugccggcgc cggaacggcu accgcgcccu gauggacaag      180

ucccugcacg uggggaccca gugcgcccuc acccggcgcu gcccccagga gggcuucgac      240

caccgggaca gcaagguguc ccugcaggag aagaacugcg agcccgucgu gcccaacgcc      300

ccgcccgcgu acgagaagcu gagcgccgag caguccccgc cgcccuacag ccccuga         357


<210>  2445
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2445
augccccgcg aggacgccca cuucaucuac ggcuacccca agaagggcca cggccacucc       60

uacaccaccg ccgaggaggc cgccggcauc ggcauccuca ccgucauccu cggcguccuc      120

cuccucaucg gcugcuggua cugccgccgc cgcaacggcu accgcgcccu cauggacaag      180

ucccuccacg ucggcaccca gugcgcccuc acccgccgcu gcccccagga gggcuucgac      240

caccgcgacu ccaaggucuc ccuccaggag aagaacugcg agcccgucgu ccccaacgcc      300

ccccccgccu acgagaagcu cuccgccgag cagucccccc cccccuacuc ccccuga         357


<210>  2446
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2446
augcccagag aggacgccca cuucaucuac ggcuauccua agaaagggca uggacacagc       60

uacaccacag cugaagaggc agccgguauu ggcauacuga cugugauccu cgggguccuu      120

cuguugauug gaugcuggua uuguaggcgg cgcaacggcu accgagcguu aauggauaag      180

ucccugcaug uugguacgca gugcgcucua acccguagau guccacaaga aggguuugac      240

cacagggauu cuaaaguguc acuccaggag aagaauugcg aaccgguagu gcccaacgcc      300

ccuccagcau augagaaacu gagugccgag cagagcccuc ccccauacuc ccccuga         357


<210>  2447
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2447
augcccagag aggacgccca cuucaucuac ggcuacccca agaagggcca cggccacagc       60

uacaccaccg ccgaggaggc cgccggcauc ggcauccuga ccgugauccu gggcgugcug      120

cugcugaucg gcugcuggua cugcagaaga agaaacggcu acagagcccu gauggacaag      180

agccugcacg ugggcaccca gugcgcccug accagaagau gcccccagga gggcuucgac      240

cacagagaca gcaaggugag ccugcaggag aagaacugcg agcccguggu gcccaacgcc      300

ccccccgccu acgagaagcu gagcgccgag cagagccccc cccccuacag ccccuga         357


<210>  2448
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MART-1/melan-A__Homo_sapiens__AAA19238

<400>  2448
augcccagag aggacgccca cuucaucuac ggcuauccua agaaagggca uggacacagc       60

uacaccacag cugaagaggc cgcgggcauu gggauccuga cggugauucu cggaguccug      120

cuucugaucg gcugcuggua uugucggcgc agaaacgggu accgggcucu cauggauaag      180

ucccugcaug uuggaaccca gugcgcccuu acacgcagau guccgcaaga aggcuuugac      240

caccgggauu cuaaagugag ccugcaggag aagaauugcg aacccguggu cccuaacgcu      300

cccccugccu augagaaacu cuccgccgag cagucucccc cuccguacag ccccuga         357


<210>  2449
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MART-2__Homo_sapiens__Q5VTY9

<400>  2449

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys His Arg Pro Trp Ile 
                85                  90                  95      


Leu Met Leu Tyr Gly Met Trp Ala Cys Trp Cys Val Leu Gly Thr Pro 
            100                 105                 110         


Gly Val Ala Met Val Leu Leu His Thr Thr Ile Ser Phe Cys Val Ala 
        115                 120                 125             


Gln Phe Arg Ser Gln Leu Leu Thr Trp Leu Cys Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Thr Leu Arg Leu Gln Gly Val Glu Glu Val Lys Arg Arg Trp Tyr 
145                 150                 155                 160 


Lys Thr Glu Asn Glu Tyr Tyr Leu Leu Gln Phe Thr Leu Thr Val Arg 
                165                 170                 175     


Cys Leu Tyr Tyr Thr Ser Phe Ser Leu Glu Leu Cys Trp Gln Gln Leu 
            180                 185                 190         


Pro Ala Ala Ser Thr Ser Tyr Ser Phe Pro Trp Met Leu Ala Tyr Val 
        195                 200                 205             


Phe Tyr Tyr Pro Val Leu His Asn Gly Pro Ile Leu Ser Phe Ser Glu 
    210                 215                 220                 


Phe Ile Lys Gln Met Gln Gln Gln Glu His Asp Ser Leu Lys Ala Ser 
225                 230                 235                 240 


Leu Cys Val Leu Ala Leu Gly Leu Gly Arg Leu Leu Cys Trp Trp Trp 
                245                 250                 255     


Leu Ala Glu Leu Met Ala His Leu Met Tyr Met His Ala Ile Tyr Ser 
            260                 265                 270         


Ser Ile Pro Leu Leu Glu Thr Val Ser Cys Trp Thr Leu Gly Gly Leu 
        275                 280                 285             


Ala Leu Ala Gln Val Leu Phe Phe Tyr Val Lys Tyr Leu Val Leu Phe 
    290                 295                 300                 


Gly Val Pro Ala Leu Leu Met Arg Leu Asp Gly Leu Thr Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Arg Cys Val Ser Thr Met Phe Ser Phe Thr Gly Met Trp Arg 
                325                 330                 335     


Tyr Phe Asp Val Gly Leu His Asn Phe Leu Ile Arg Tyr Val Tyr Ile 
            340                 345                 350         


Pro Val Gly Gly Ser Gln His Gly Leu Leu Gly Thr Leu Phe Ser Thr 
        355                 360                 365             


Ala Met Thr Phe Ala Phe Val Ser Tyr Trp His Gly Gly Tyr Asp Tyr 
    370                 375                 380                 


Leu Trp Cys Trp Ala Ala Leu Asn Trp Leu Gly Val Thr Val Glu Asn 
385                 390                 395                 400 


Gly Val Arg Arg Leu Val Glu Thr Pro Cys Ile Gln Asp Ser Leu Ala 
                405                 410                 415     


Arg Tyr Phe Ser Pro Gln Ala Arg Arg Arg Phe His Ala Ala Leu Ala 
            420                 425                 430         


Ser Cys Ser Thr Ser Met Leu Ile Leu Ser Asn Leu Val Phe Leu Gly 
        435                 440                 445             


Gly Asn Glu Val Gly Lys Thr Tyr Trp Asn Arg Ile Phe Ile Gln Gly 
    450                 455                 460                 


Trp Pro Trp Val Thr Leu Ser Val Leu Gly Phe Leu Tyr Cys Tyr Ser 
465                 470                 475                 480 


His Val Gly Ile Ala Trp Ala Gln Thr Tyr Ala Thr Asp 
                485                 490             


<210>  2450
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MART-2__Homo_sapiens__EAW93427

<400>  2450
augcugcccc gaugggaacu ggcacuuuac cuacuugccu cacuaggcuu ccacuucuau       60

uccuucuaug aaguuuacaa agucuccaga gaacacgaag aggagcugga ccaggaauuu      120

gagcuggaga cugacacuuu auuuggagga uuaaagaagg augcgaccga cuuugagugg      180

agcuucugga uggaaugggg gaagcagugg cugguguggc uucuccuugg ccacauggua      240

gugucucaaa uggccacacu gcuggcaaga aagcacagac ccuggauucu caugcucuau      300

gggauguggg ccugcuggug ugugcugggg accccuggug uggcuauggu uuugcuccau      360

accaccaucu cuuucugcgu ggcccaguuc cggucucagc uccugacgug gcucuguucu      420

cuccuccucc ucuccacacu gaggcugcag gguguggaag aaguuaagag aaggugguac      480

aagacagaaa acgaguacua ccugcugcag uucacgcuga ccguucgcug ccucuacuac      540

accagcuuca gccuggagcu cugcuggcag cagcugccug cugcaucgac cuccuacucc      600

uuucccugga ugcuggccua ugucuuuuau uauccagucu uacacaaugg gcccauccuc      660

agcuucucgg aguucaucaa acagaugcag cagcaggagc augacucccu gaaggccagc      720

cugugugucc uggcccuggg gcugggccgc cuucuuugcu ggugguggcu ggccgagcug      780

auggcucacc ugauguacau gcaugccauc uacagcagca ucccccuccu ggagacuguc      840

ucuuguugga ccuuaggagg acuggcguua gcccaggugc ucuuuuucua cgugaaguac      900

uuggugcucu uuggcgugcc ugcucugcuc augcgccugg auggacucac uccacccgcc      960

cucccccgcu gcgugagcac cauguucagu uucaccggga uguggaggua uuuugauguu     1020

ggacugcaua auuucuuaau cagguaugug uacauuccag ugggcggguc ccagcauggc     1080

cugcugggga cacuguuuuc cacggcgaug acauuugcau uugugagcua cuggcauggc     1140

ggcuacgacu accucuggug cugggcagcg cucaacuggc ugggagucac uguggagaau     1200

ggaguccgga ggcuggugga gacucccugc auccaggaca gucuggcccg auacuucucc     1260

ccacaagcuc gccgucgauu ccacgcugcc cuugcuucuu guuccaccuc gaugcugauc     1320

cuguccaacc ugguauuucu ugggggcaau gagguuggga aaaccuacug gaauaggauc     1380

uucauacaag gcuggccuug ggugacccuc ucuguccugg gauuccugua cugcuacucc     1440

cacgugggca uugccugggc ccagaccuac gccacggacu aa                        1482


<210>  2451
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MART-2__Homo_sapiens__EAW93427

<400>  2451
augcugcccc gcugggagcu cgcccuguac cugcucgcca gccugggcuu ccacuucuac       60

uccuucuacg agguguacaa ggucagccgg gagcacgagg aggagcugga ccaggaguuc      120

gagcucgaga ccgacacccu guucgggggc cugaagaagg acgcgacgga cuucgagugg      180

uccuucugga uggagugggg gaagcagugg cucguguggc ugcugcucgg ccacauggug      240

gucagccaga uggccacccu gcuggcccgc aagcaccggc cguggauccu caugcuguac      300

gggauguggg ccugcuggug cgugcugggc acccccggcg uggccauggu ccuccugcac      360

accacgaucu ccuucugcgu ggcgcaguuc cgcagccagc ugcucaccug gcugugcucc      420

cugcuccugc ugagcacccu ccggcugcag gggguggagg aggucaagcg ccggugguac      480

aagaccgaga acgaguacua ccugcuccag uucacgcuga ccgugcgcug ccuguacuac      540

accuccuuca gccucgagcu gugcuggcag cagcugcccg ccgccuccac cagcuacucc      600

uuccccugga ugcucgccua cguguucuac uacccggucc ugcacaacgg ccccauccug      660

agcuucuccg aguucaucaa gcagaugcag cagcaggagc acgacagccu caaggcgucc      720

cugugcgugc uggcccucgg gcugggccgg cugcucugcu ggugguggcu ggccgagcug      780

auggcccacc ucauguacau gcacgccauc uacagcucca ucccccugcu ggagacggug      840

agcugcugga cccucggggg ccuggcgcug gcccaggucc uguucuucua cgugaaguac      900

cucgugcugu ucggcguccc cgcccugcuc augcgccugg acgggcugac cccgcccgcc      960

cucccccggu gcgugagcac cauguucucc uucacgggca uguggcgcua cuucgacgug     1020

gggcugcaca acuuccugau ccgguacguc uacauccccg ugggcggcag ccagcacggg     1080

cuccugggca cccuguucuc caccgccaug accuucgcgu ucgugagcua cuggcacggg     1140

ggcuacgacu accucuggug cugggccgcc cugaacuggc ugggggucac gguggagaac     1200

ggcguccgcc ggcucgugga gaccccgugc auccaggacu cccuggcccg cuacuucagc     1260

ccccaggccc ggcgccgguu ccacgcggcc cuggccuccu gcagcaccuc caugcucauc     1320

cugagcaacc ugguguuccu cggcgggaac gaggucggca agaccuacug gaaccgcauc     1380

uucauccagg gguggcccug ggugacgcug uccgugcugg gcuuccucua cugcuacagc     1440

cacgucggga ucgccugggc ccagaccuac gcgaccgacu ga                        1482


<210>  2452
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MART-2__Homo_sapiens__EAW93427

<400>  2452
augcuccccc gcugggagcu cgcccucuac cuccucgccu cccucggcuu ccacuucuac       60

uccuucuacg aggucuacaa ggucucccgc gagcacgagg aggagcucga ccaggaguuc      120

gagcucgaga ccgacacccu cuucggcggc cucaagaagg acgccaccga cuucgagugg      180

uccuucugga uggagugggg caagcagugg cucgucuggc uccuccucgg ccacaugguc      240

gucucccaga uggccacccu ccucgcccgc aagcaccgcc ccuggauccu caugcucuac      300

ggcauguggg ccugcuggug cguccucggc acccccggcg ucgccauggu ccuccuccac      360

accaccaucu ccuucugcgu cgcccaguuc cgcucccagc uccucaccug gcucugcucc      420

cuccuccucc ucuccacccu ccgccuccag ggcgucgagg aggucaagcg ccgcugguac      480

aagaccgaga acgaguacua ccuccuccag uucacccuca ccguccgcug ccucuacuac      540

accuccuucu cccucgagcu cugcuggcag cagcuccccg ccgccuccac cuccuacucc      600

uuccccugga ugcucgccua cgucuucuac uaccccgucc uccacaacgg ccccauccuc      660

uccuucuccg aguucaucaa gcagaugcag cagcaggagc acgacucccu caaggccucc      720

cucugcgucc ucgcccucgg ccucggccgc cuccucugcu ggugguggcu cgccgagcuc      780

auggcccacc ucauguacau gcacgccauc uacuccucca ucccccuccu cgagaccguc      840

uccugcugga cccucggcgg ccucgcccuc gcccaggucc ucuucuucua cgucaaguac      900

cucguccucu ucggcguccc cgcccuccuc augcgccucg acggccucac cccccccgcc      960

cucccccgcu gcgucuccac cauguucucc uucaccggca uguggcgcua cuucgacguc     1020

ggccuccaca acuuccucau ccgcuacguc uacauccccg ucggcggcuc ccagcacggc     1080

cuccucggca cccucuucuc caccgccaug accuucgccu ucgucuccua cuggcacggc     1140

ggcuacgacu accucuggug cugggccgcc cucaacuggc ucggcgucac cgucgagaac     1200

ggcguccgcc gccucgucga gacccccugc auccaggacu cccucgcccg cuacuucucc     1260

ccccaggccc gccgccgcuu ccacgccgcc cucgccuccu gcuccaccuc caugcucauc     1320

cucuccaacc ucgucuuccu cggcggcaac gaggucggca agaccuacug gaaccgcauc     1380

uucauccagg gcuggcccug ggucacccuc uccguccucg gcuuccucua cugcuacucc     1440

cacgucggca ucgccugggc ccagaccuac gccaccgacu ga                        1482


<210>  2453
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MART-2__Homo_sapiens__EAW93427

<400>  2453
augcugccca gaugggagcu cgcccuuuac cuguuggcua gcuuaggcuu ccacuuuuau       60

uccuucuacg aaguguauaa ggucucuagg gagcaugaag aggaacugga ccaggaguuu      120

gagcuagaaa ccgauacacu cuucggggga cugaaaaagg acgcaacuga uuuugagugg      180

ucauucugga uggaaugggg uaaacaaugg cuuguuuggc uguugcucgg ccacauggug      240

guaagucaga uggccacgcu gcuggcgcgg aagcaucgcc cuuggauccu cauguuauac      300

gggauguggg cuugcuggug ugugcuggga accccaggcg ucgccauggu gcuuuugcac      360

acaacuauua gcuuuugcgu ugcacaguuc cgaucccagc ugcuaaccug gcucuguucu      420

cugcuucugu ugucgacacu ccgucugcaa gguguggagg aggucaaaag aaggugguau      480

aagaccgaaa acgaguacua uuuacugcag uuuacucuca cagugcggug ccuuuacuac      540

accucauuca gccuggaauu guguuggcag cagcuaccgg ccgcuaguac guccuauucu      600

uuucccugga ugcuggcaua cguauucuau uacccuguuc uccauaaugg gccaauacug      660

agcuuuuccg aguucaucaa gcaaaugcag cagcaggaac acgacucacu uaaagccagu      720

cugugcgugu uggcucucgg acugggccgc uuacuguguu ggugguggcu agccgagcuc      780

auggcgcacc ugauguauau gcaugcaauu uacagcucua ucccccuuuu ggagacuguc      840

uccugcugga cccugggcgg gcucgcccug gcucaagugc uuuucuuuua ugugaaguac      900

cuggucuugu ucggaguucc ugcccuccug augagauuag auggucugac accacccgca      960

cuaccuaggu gugugucaac uauguuuagc uucaccggca uguggcggua cuuugacgua     1020

gggcuccaca acuuccugau ucgcuaugug uacaucccag ucggaggcag ucagcauggu     1080

cuuuugggga cacuguuuuc uaccgcuaug acguucgccu uuguguccua uuggcacgga     1140

ggcuacgauu aucucuggug cugggcggcc cugaauuggu uaggcguuac uguggaaaac     1200

gggguccgaa gacuggugga gacaccgugu auacaggaca gccuugcaag guacuucucg     1260

ccccaagcuc ggcgucgcuu ucacgccgcu uuggccucuu gcuccaccuc aaugcucauc     1320

cugaguaauc uaguauuccu gggagguaac gaaguuggca aaacuuauug gaauagaauu     1380

uuuauccagg gguggccuug ggugacacuc agcguccugg gauuccuuua cugcuacucc     1440

caugugggca uugcaugggc ccagaccuau gcuacggauu ga                        1482


<210>  2454
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MART-2__Homo_sapiens__EAW93427

<400>  2454
augcugccca gaugggagcu ggcccuguac cugcuggcca gccugggcuu ccacuucuac       60

agcuucuacg agguguacaa ggugagcaga gagcacgagg aggagcugga ccaggaguuc      120

gagcuggaga ccgacacccu guucggcggc cugaagaagg acgccaccga cuucgagugg      180

agcuucugga uggagugggg caagcagugg cugguguggc ugcugcuggg ccacauggug      240

gugagccaga uggccacccu gcuggccaga aagcacagac ccuggauccu gaugcuguac      300

ggcauguggg ccugcuggug cgugcugggc acccccggcg uggccauggu gcugcugcac      360

accaccauca gcuucugcgu ggcccaguuc agaagccagc ugcugaccug gcugugcagc      420

cugcugcugc ugagcacccu gagacugcag ggcguggagg aggugaagag aagaugguac      480

aagaccgaga acgaguacua ccugcugcag uucacccuga ccgugagaug ccuguacuac      540

accagcuuca gccuggagcu gugcuggcag cagcugcccg ccgccagcac cagcuacagc      600

uuccccugga ugcuggccua cguguucuac uaccccgugc ugcacaacgg ccccauccug      660

agcuucagcg aguucaucaa gcagaugcag cagcaggagc acgacagccu gaaggccagc      720

cugugcgugc uggcccuggg ccugggcaga cugcugugcu ggugguggcu ggccgagcug      780

auggcccacc ugauguacau gcacgccauc uacagcagca ucccccugcu ggagaccgug      840

agcugcugga cccugggcgg ccuggcccug gcccaggugc uguucuucua cgugaaguac      900

cuggugcugu ucggcgugcc cgcccugcug augagacugg acggccugac cccccccgcc      960

cugcccagau gcgugagcac cauguucagc uucaccggca uguggagaua cuucgacgug     1020

ggccugcaca acuuccugau cagauacgug uacauccccg ugggcggcag ccagcacggc     1080

cugcugggca cccuguucag caccgccaug accuucgccu ucgugagcua cuggcacggc     1140

ggcuacgacu accuguggug cugggccgcc cugaacuggc ugggcgugac cguggagaac     1200

ggcgugagaa gacuggugga gacccccugc auccaggaca gccuggccag auacuucagc     1260

ccccaggcca gaagaagauu ccacgccgcc cuggccagcu gcagcaccag caugcugauc     1320

cugagcaacc ugguguuccu gggcggcaac gaggugggca agaccuacug gaacagaauc     1380

uucauccagg gcuggcccug ggugacccug agcgugcugg gcuuccugua cugcuacagc     1440

cacgugggca ucgccugggc ccagaccuac gccaccgacu ga                        1482


<210>  2455
<211>  1482
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MART-2__Homo_sapiens__EAW93427

<400>  2455
augcugccca gaugggagcu cgcccuguac cuucuggcua gccucggcuu ccacuuuuau       60

uccuucuacg aaguguauaa ggucucucgg gagcaugaag aggaacugga ccaggaguuu      120

gagcuugaaa ccgauacacu guucggggga cucaaaaagg acgccacgga uuuugagugg      180

agcuucugga uggaaugggg caaacaaugg cugguuuggc ugcuccuggg gcacauggug      240

gugucccaga uggcgacccu ucuggcucgc aagcauagac cuuggauccu caugcuguac      300

ggaauguggg ccugcuggug uguccuuggc acaccggggg uggccauggu ucugcuccac      360

accacaauuu cuuuuugcgu ggcucaguuc cggagccagc ugcugaccug gcucuguucc      420

cugcuucugc ucucuacacu gcgccuucaa ggagucgagg aggugaaaag acggugguau      480

aagaccgaaa acgaguacua ucugcuccag uuuacgcuga ccguucgcug ccuguacuac      540

acauccuucu cccucgaacu guguuggcag cagcuucccg ccgcuagcac cucuuauucc      600

uuuccuugga ugcuggccua cguguucuau uaccccgucc uccauaaugg cccuauccug      660

agcuuuucug aguucauuaa gcaaaugcag cagcaggaac acgacucccu uaaagcgagc      720

cugugcgugc ucgcccuggg ccuggggaga cuccuguguu ggugguggcu ugcugagcug      780

auggcccacc ucauguauau gcaugcuauc uacucuucca uuccccugcu ggagacagug      840

agcugcugga cccuuggagg ccucgcccug gcgcaagucc uguucuuuua uguuaaguac      900

cucgugcugu ucggggugcc ugcccuucug augcggcucg auggacugac gccgcccgcu      960

cugccucgcu gugucuccac aauguuuucu uucaccggca uguggagaua cuuugacgug     1020

gggcuucaca acuuccucau ccgguauguu uacauccccg ugggaggcag ccagcauggc     1080

cugcugggga cacucuuuuc caccgccaug accuucgcuu uugucagcua uuggcacgga     1140

ggcuacgauu aucuguggug cugggccgcc cuuaauuggc ugggggugac aguugaaaac     1200

ggagugcgca gacucgucga gacgccuugu auucaggacu cucuggcucg guacuucagc     1260

ccccaagcgc gcagacgguu ucacgccgcu cuggccagcu gcucuaccag caugcuuauc     1320

cucuccaauc ugguguuccu gggcgggaac gaagucggaa aaacauauug gaauagaauu     1380

uuuauccagg gcuggccgug ggugacccuc ucuguucugg gcuuccuuua cugcuacagc     1440

caugugggga uugccugggc ucagacauau gccaccgauu ga                        1482


<210>  2456
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q01726

<400>  2456

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2457
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAD41349

<400>  2457
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2458
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAD41349

<400>  2458
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2459
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAD41349

<400>  2459
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2460
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAD41349

<400>  2460
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2461
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAD41349

<400>  2461
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2462
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAD41349

<400>  2462
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2463
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUL4

<400>  2463

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2464
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09522

<400>  2464
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2465
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09522

<400>  2465
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2466
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09522

<400>  2466
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2467
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09522

<400>  2467
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2468
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09522

<400>  2468
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2469
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09522

<400>  2469
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2470
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUL6

<400>  2470

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Gln Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2471
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09804

<400>  2471
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcaag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2472
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09804

<400>  2472
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccagg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2473
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09804

<400>  2473
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccagg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2474
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09804

<400>  2474
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcagg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcucgcg ccugucagca cgcacagggg      660

aucgccagac uccauaaaag gcaacggccc gugcaccagg gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2475
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09804

<400>  2475
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagacagg ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2476
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09804

<400>  2476
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgccagg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcuagag ccugucagca cgcccagggc      660

aucgcucggc uccauaaacg ccaaagaccu guucaccagg gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2477
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUL8

<400>  2477

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Thr Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2478
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94313

<400>  2478
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucacu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2479
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94313

<400>  2479
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugacc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca cgauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacccuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga cgugcagcug guga            954


<210>  2480
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94313

<400>  2480
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucacc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2481
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94313

<400>  2481
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugaca      360

gauguaauca cuugcaguuc caugcugucu agccuuuguu uccugggugc aauugccguu      420

gaccguuaua ucuccauauu uuacgcuuug agauaucauu caaucgugac ccucccgagg      480

gcccggcgcg cagucgcugc cauuugggug gcgagugugg ucuucagcac acuguuuauc      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

auugccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacccuua cuauccuguu ggggauauuu uuccucugcu ggggacccuu uuuccugcac      780

uuaacacuga uugugcuaug uccagagcau ccuaccugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau uaucugcaau gcaaucauug acccuuugau auaugccuuu      900

cacucucagg aacugcgaag aacgcucaag gagguacuga cuugcuccug guga            954


<210>  2482
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94313

<400>  2482
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugacc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2483
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94313

<400>  2483
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuacc      360

gaugugauua caugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac ccugccccgg      480

gcccgcagag cuguggccgc uauuuggguc gccagcguug uguucucuac acuuuuuauc      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

auugcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacccuua cgauccugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacccuga uuguccuuug uccugagcau cccacaugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccucugau uuaugccuuu      900

cacucccagg aacuucgcag aacccucaag gaggugcuga caugcagcug guga            954


<210>  2484
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUL9

<400>  2484

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Met Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2485
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09531

<400>  2485
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacaugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga cgugcuccug guga            954


<210>  2486
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09531

<400>  2486
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacaugcugg agaccgccgu cauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccgugcucc agcagcugga caacgucauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcggug      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgucac ccucccccgg      480

gcccgccggg ccguggccgc gaucugggug gccuccgucg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cguccugcuc ugccuggugg uguucuuccu ggccaugcuc      600

guccugaugg cggugcugua cgugcacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu gaagggggcg      720

gugacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucguccugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2487
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09531

<400>  2487
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacaugcucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2488
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09531

<400>  2488
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauauguuag agaccgcugu gauucugcuu      300

uuggaagcag gcgcccuggu ugcucgagcc gcggugcuac agcaacucga caacgucauc      360

gaugugauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccgua      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauuguuac ucucccgagg      480

gcccggcgcg caguggcugc caucuggguc gcgagugugg uguucagcac ccuguuuauu      540

gccuacuaug aucacgucgc aguuuuacug ugccucgugg uauucuuucu ugcuaugcug      600

guguugaugg ccguccuaua cgugcauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc guucaccaag gauucggccu gaagggcgcu      720

gugacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uuguccuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gaggugcuga cgugcuccug guga            954


<210>  2489
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09531

<400>  2489
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacaugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2490
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09531

<400>  2490
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauaugcugg agacagcugu uauccuucug      300

cucgaagccg gggcgcuggu ggcccgggcu gccguccugc agcaacucga caacgugauu      360

gauguuauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccgug      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugucac acugccccgg      480

gcccgcagag cuguggccgc uaucugggug gccagcgucg uuuucucuac ccuuuuuauu      540

gccuacuaug aucacguggc ugugcugcuc ugccuggucg uguucuuucu ggcgaugcuc      600

guucugaugg ccgugcuuua cguccauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu gugcaccaag gcuucgggcu gaagggagcc      720

guuacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucgugcuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gagguccuga ccugcagcug guga            954


<210>  2491
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUM0

<400>  2491

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Gln Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Gln Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2492
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94311

<400>  2492
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaacca gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcaag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2493
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94311

<400>  2493
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaacca gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgggcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgcuaca ucuccaucuu cuacgcccug cgguaccaca gcaucgugac ccucccccgc      480

gcccggcagg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2494
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94311

<400>  2494
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaacca gaaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccagg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2495
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94311

<400>  2495
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaauca gaacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgcgcc gcgguccuac aacagcucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccgauaua uauccaucuu uuacgcuuug cguuaucauu caauugugac ucucccgaga      480

gccaggcagg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcucggg ccugucagca cgcacaaggg      660

aucgcccgcc uccauaaaag acagaggccc gugcaccagg gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcggcg cacccucaag gagguacuga cgugcuccug guga            954


<210>  2496
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94311

<400>  2496
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacca gaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagacagg ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2497
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94311

<400>  2497
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauca gaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgccagagcu gccgugcugc aacagcucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgguaua ucucuaucuu uuacgcgcuc cgcuaucauu ccauugugac acugcccaga      480

gcccggcagg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucgcg ccugucagca cgcccaaggc      660

aucgcuagac uccauaaacg gcagcgcccu guucaccagg gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuuagacg gacacucaag gaggugcuga ccugcagcug guga            954


<210>  2498
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUM2

<400>  2498

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Gln Ala Val Gly Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2499
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94309

<400>  2499
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcaag ccguuggggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2500
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94309

<400>  2500
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccagg ccgugggcgc caucuggguc gcguccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg ccgugcugua cguccacaug cucgcgcggg ccugccagca cgcccagggg      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gcuucgggcu gaagggcgcc      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu gggggccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc ucgcgcugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2501
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94309

<400>  2501
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccagg ccgucggcgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2502
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94309

<400>  2502
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcagg cagucggggc uaucugggug gccagugugg ucuucagcac ccuguuuauu      540

gcguacuaug aucacguugc cguguuacug ugccucguag uguucuuucu ugcaaugcug      600

gucuugaugg cugugcuaua cguucauaug cuggcccgcg cuugucagca cgcccaggga      660

aucgcaagac uccauaaaag gcaacggccc gugcaccagg gcuucggccu gaagggggcc      720

gucacacuua ccauacuguu gggaaucuuu uuccucugcu gggguccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg gcuguauuuu uaaaaauuuc      840

aaccucuucc uggcucuuau caucugcaau gcgauuauag acccuuugau cuaugcauuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2503
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94309

<400>  2503
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagacagg ccgugggcgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2504
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94309

<400>  2504
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgccagg cugugggcgc caucuggguc gcuagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc cguccugcuc ugccuggugg uuuucuuucu ggcuaugcuc      600

gugcugaugg cgguccuuua cgugcauaug cuggccagag cuugucagca cgcccagggc      660

aucgcccggc uccauaaacg ccaaagaccu guucaccagg gguucggacu gaagggcgcu      720

gugacacuua ccauucugcu cgggaucuuu uuccugugcu ggggacccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gcuguauuuu uaaaaauuuc      840

aaccuguucc ucgcccugau cauuugcaau gcgaucauug acccccugau cuaugcuuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2505
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUM3

<400>  2505

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Thr Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Thr Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2506
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94308

<400>  2506
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucacu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugacgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2507
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94308

<400>  2507
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugacc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucacccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacgcuca ccauccugcu gggcaucuuc uuccucugcu ggggccccuu cuuccugcac      780

cugacccuca ucgugcugug cccggagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacgcucaag gaggugcuga ccugcagcug guga            954


<210>  2508
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94308

<400>  2508
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucacc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucacccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2509
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94308

<400>  2509
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugaca      360

gauguaauca cuugcaguuc caugcugucu agccuuuguu uccugggugc aauugccguu      420

gaccguuaua ucuccauauu uuacgcuuug agauaucauu caaucgugac ccucacaagg      480

gcccggcgcg cagucgcugc cauuugggug gcgagugugg ucuucagcac ccuguuuauc      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

auugccaggc uccauaaacg gcagcgcccg gugcaccaag gauucggccu gaagggcgcu      720

gucacucuua caauccuguu ggggauauuu uuccucugcu ggggacccuu uuuccugcac      780

uuaacccuga uugugcuaug uccugagcau ccaacgugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau uaucugcaau gcaaucauug accccuugau auaugccuuu      900

cacucucagg aacugcgaag aacucucaag gagguacuga ccugcuccug guga            954


<210>  2510
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94308

<400>  2510
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugacc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugaccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2511
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94308

<400>  2511
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuacc      360

gaugugauua caugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac ccugacacgg      480

gcccgcagag cuguggccgc uauuuggguc gccagcguug uguucucuac ccuuuuuauc      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

auugcucgcc uccauaaaag acagcggccc guucaccaag gcuucgggcu gaagggagcc      720

gugacgcuua ccauccugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacacuga uuguccuuug uccugagcau ccuaccugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccccugau uuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2512
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUM4

<400>  2512

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Met Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Ile Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2513
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94307

<400>  2513
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacaugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugau ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga cgugcuccug guga            954


<210>  2514
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94307

<400>  2514
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccgcagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacaugcugg agaccgccgu cauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccgugcucc agcagcugga caacgucauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcggug      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgucau ccucccccgg      480

gcccgccggg ccguggccgc gaucugggug gccuccgucg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cguccugcuc ugccuggugg uguucuuccu ggccaugcuc      600

guccugaugg cggugcugua cgugcacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu gaagggggcg      720

gugacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacccuca ucguccugug ccccgagcac cccacgugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2515
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94307

<400>  2515
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacaugcucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucau ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2516
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94307

<400>  2516
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauauguuag agaccgcugu gauucugcuu      300

uuggaagcag gcgcccuggu ugcucgagcc gcggugcuac agcaacucga caacgucauc      360

gaugugauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccgua      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauuguuau ccucccgagg      480

gcccggcgcg caguggcugc cauuuggguc gcgagugugg uguucagcac ucuguuuauc      540

gccuacuaug aucacgucgc aguuuuacug ugccucgugg uauucuuucu ugcuaugcug      600

guguugaugg ccguccuaua cgugcauaug cuggcuagag ccugucagca cgcacagggg      660

auagccaggc uccauaaacg gcagcgcccc guucaccaag gauucggccu gaagggcgcu      720

gugacccuua caauucuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacccuga uuguccuaug uccugagcau cccacuugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau cauuugcaau gcaauaaucg acccuuugau uuaugccuuu      900

cacucucagg aacugcgaag aacacucaag gaggugcuga ccugcuccug guga            954


<210>  2517
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94307

<400>  2517
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacaugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugau ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2518
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94307

<400>  2518
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauaugcugg agacagcugu uauccuucug      300

cucgaagccg gggcgcuggu ggcccgggcu gccguccugc agcaacucga caacgugauu      360

gauguuauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccgug      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugucau ccugccccgg      480

gcccgcagag cuguggccgc uauuugggug gccagcgucg uuuucucuac acuuuuuauc      540

gccuacuaug aucacguggc ugugcugcuc ugccuggucg uguucuuucu ggcgaugcuc      600

guucugaugg ccgugcuuua cguccauaug cuggcucggg ccugucagca cgcccagggc      660

auugcucgcc uccauaaaag acagcggccu gugcaccaag gcuucgggcu gaagggagcc      720

guuacccuua caauccugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacccuga uugugcuuug uccugagcau cccacgugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccucugau cuaugccuuu      900

cacucccagg aacuucgcag aacccucaag gagguccuga caugcagcug guga            954


<210>  2519
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q1JUM5

<400>  2519

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg Ala 
145                 150                 155                 160 


Arg Gln Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser Thr 
                165                 170                 175     


Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu Val 
            180                 185                 190         


Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val His 
        195                 200                 205             


Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu His 
    210                 215                 220                 


Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala Val 
225                 230                 235                 240 


Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro Phe 
                245                 250                 255     


Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr Cys 
            260                 265                 270         


Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile Cys 
        275                 280                 285             


Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu Leu 
    290                 295                 300                 


Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315     


<210>  2520
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__BAE94306

<400>  2520
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucua cgcacugcgc uaccacagca ucgugacccu gccgcgggcg      480

cggcaagccg uugcggccau cuggguggcc agugucgucu ucagcacgcu cuucaucgcc      540

uacuacgacc acguggccgu ccugcugugc cucguggucu ucuuccuggc uaugcuggug      600

cucauggccg ugcuguacgu ccacaugcug gcccgggccu gccagcacgc ccagggcauc      660

gcccggcucc acaagaggca gcgcccgguc caccagggcu uuggccuuaa aggcgcuguc      720

acccucacca uccugcuggg cauuuucuuc cucugcuggg gccccuucuu ccugcaucuc      780

acacucaucg uccucugccc cgagcacccc acgugcggcu gcaucuucaa gaacuucaac      840

cucuuucucg cccucaucau cugcaaugcc aucaucgacc cccucaucua cgccuuccac      900

agccaggagc uccgcaggac gcucaaggag gugcugacau gcuccuggug a               951


<210>  2521
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__BAE94306

<400>  2521
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucua cgcccugcgc uaccacagca ucgugacccu cccccgggcc      480

cgccaggccg uggccgcgau cugggucgcc uccguggugu ucagcacccu guucaucgcc      540

uacuacgacc acgucgccgu gcugcucugc cugguggucu ucuuccuggc caugcucgug      600

cugauggcgg ugcuguacgu ccacaugcuc gcccgggccu gccagcacgc ccagggcauc      660

gcccgccugc acaagcggca gcgccccgug caccaggggu ucggccugaa gggggcgguc      720

acccucacca uccugcuggg caucuucuuc cucugcuggg gcccguucuu ccugcaccug      780

acgcucaucg ugcugugccc cgagcacccg accugcgggu gcaucuucaa gaacuucaac      840

cuguuccucg cccugaucau cugcaacgcc aucaucgacc cccugaucua cgccuuccac      900

ucccaggagc ugcggcgcac ccucaaggag gugcugaccu gcagcuggug a               951


<210>  2522
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__BAE94306

<400>  2522
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucua cgcccuccgc uaccacucca ucgucacccu cccccgcgcc      480

cgccaggccg ucgccgccau cugggucgcc uccgucgucu ucuccacccu cuucaucgcc      540

uacuacgacc acgucgccgu ccuccucugc cucgucgucu ucuuccucgc caugcucguc      600

cucauggccg uccucuacgu ccacaugcuc gcccgcgccu gccagcacgc ccagggcauc      660

gcccgccucc acaagcgcca gcgccccguc caccagggcu ucggccucaa gggcgccguc      720

acccucacca uccuccucgg caucuucuuc cucugcuggg gccccuucuu ccuccaccuc      780

acccucaucg uccucugccc cgagcacccc accugcggcu gcaucuucaa gaacuucaac      840

cucuuccucg cccucaucau cugcaacgcc aucaucgacc cccucaucua cgccuuccac      900

ucccaggagc uccgccgcac ccucaaggag guccucaccu gcuccuggug a               951


<210>  2523
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__BAE94306

<400>  2523
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucua cgcuuugaga uaucauucaa uugugacucu cccgagggcc      480

cggcaggcag ucgcugccau cuggguggcg aguguggucu uuagcacccu guucauugcc      540

uacuaugauc acguugcagu guuacugugc cucguagugu uuuuccuugc uaugcugguc      600

uugauggccg ugcuauacgu ucauaugcug gcucgcgccu gucagcacgc acaggggauc      660

gccagacucc auaaaaggca acggcccgug caccagggau uuggccugaa gggcgcuguc      720

acacuuacca uacuguuggg gauuuucuuu cucugcuggg gaccuuucuu ucugcacuua      780

acucugaucg ugcuaugucc agagcauccc acaugcgguu guauuuucaa aaauuuuaac      840

cucuuccugg cgcuuaucau cugcaaugca auuauagacc cuuugaucua ugccuuccac      900

ucucaggaac ugcgccgaac ccucaaggag guacugacgu gcuccuggug a               951


<210>  2524
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__BAE94306

<400>  2524
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucua cgcccugaga uaccacagca ucgugacccu gcccagagcc      480

agacaggccg uggccgccau cuggguggcc agcguggugu ucagcacccu guucaucgcc      540

uacuacgacc acguggccgu gcugcugugc cugguggugu ucuuccuggc caugcuggug      600

cugauggccg ugcuguacgu gcacaugcug gccagagccu gccagcacgc ccagggcauc      660

gccagacugc acaagagaca gagacccgug caccagggcu ucggccugaa gggcgccgug      720

acccugacca uccugcuggg caucuucuuc cugugcuggg gccccuucuu ccugcaccug      780

acccugaucg ugcugugccc cgagcacccc accugcggcu gcaucuucaa gaacuucaac      840

cuguuccugg cccugaucau cugcaacgcc aucaucgacc cccugaucua cgccuuccac      900

agccaggagc ugagaagaac ccugaaggag gugcugaccu gcagcuggug a               951


<210>  2525
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__BAE94306

<400>  2525
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucua cgcgcucaga uaucauucca uugugacacu gccccgggcc      480

cgccaggcug uggccgcuau cugggucgcc agcguugugu uuucuacccu uuucauugcc      540

uacuaugauc acguggcugu ccugcucugc cugguggugu uuuuccuggc gaugcucguu      600

cugauggccg uccuuuacgu gcauaugcug gcuagagccu gucagcacgc ccagggcauc      660

gcucggcucc auaaacgcca aagaccuguu caccagggcu uugggcugaa gggagccgug      720

acacuuacca uucugcucgg caucuucuuu cugugcuggg ggcccuucuu ucugcaccuc      780

acgcugaucg uccuuugucc ugagcauccu accugcggau guauuuucaa aaauuuuaac      840

cuguuccucg cgcugaucau uugcaaugcu aucauugacc cccugaucua ugccuuccac      900

ucccaggaac uucggcgcac acucaaggag gugcugaccu gcagcuggug a               951


<210>  2526
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR92

<400>  2526

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Ile Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2527
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62977

<400>  2527
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucauccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2528
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62977

<400>  2528
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucauccugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2529
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62977

<400>  2529
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucauccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2530
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62977

<400>  2530
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uuauucuaug uccugagcau cccacaugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau cauuugcaau gcaauaaucg acccuuugau uuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gaggugcuga cgugcuccug guga            954


<210>  2531
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62977

<400>  2531
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucauccugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2532
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62977

<400>  2532
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucauucuuug uccugagcau ccuaccugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gagguccuga ccugcagcug guga            954


<210>  2533
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR94

<400>  2533

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Val Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2534
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62975

<400>  2534
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu guggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2535
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62975

<400>  2535
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gucgugcucc agcagcugga caacgugauc      360

gacgucauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgccgug      420

gaccgguaca ucuccaucuu cuacgcgcug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccgucgccgc caucugggug gcguccgugg ucuucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcuc ugccuggucg uguucuuccu ggccaugcuc      600

gugcugaugg ccguccugua cgugcacaug cucgcgcgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu gaagggggcc      720

gugacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcgcugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gagguccuga ccugcagcug guga            954


<210>  2536
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62975

<400>  2536
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gucguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2537
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62975

<400>  2537
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gucgugcuac agcaacucga caacguaauc      360

gauguuauua caugcaguuc caugcugucu agccuuuguu uccugggugc gaucgcagug      420

gaccguuaua uauccaucuu uuacgccuug agauaucauu caauugucac ucucccgagg      480

gcucggcgcg ccguggcagc uaucugggug gccagugucg uuuucagcac ccuguuuauu      540

gcguacuaug aucacguggc cguauuacug ugccucgugg ucuucuuucu ugcaaugcug      600

guguugaugg cuguucuaua cgugcauaug cuggccagag cuugucagca cgcccagggg      660

aucgcaaggc uccauaaacg gcagcgcccc guccaccaag gauucggccu gaagggcgcc      720

gugacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uuguacuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcucuuau caucugcaau gcgauuauag acccuuugau cuaugcauuu      900

cacucucagg aacugcgaag aacccucaag gagguucuga cgugcuccug guga            954


<210>  2538
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62975

<400>  2538
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc guggugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2539
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62975

<400>  2539
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gugguucugc agcaacucga caacgugauu      360

gaugucauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc caucgcugug      420

gaccgcuaua ucucuaucuu uuacgcccuc agauaucauu ccauugugac acugccccgg      480

gcgcgcagag ccgucgcugc caucuggguu gcuagcgugg uguucucuac ccuuuuuauu      540

gccuacuaug aucacgucgc cgugcugcuc ugccugguug uguucuuucu ggcuaugcuc      600

guccugaugg cggugcuuua cguucauaug cuggcccggg cuugucagca cgcccagggc      660

aucgcccgcc uccauaaaag acagcggccu gugcaccaag gcuucgggcu gaagggagcu      720

gucacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucgugcuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcccugau cauuugcaau gcgaucauug acccccugau cuaugcuuuu      900

cacucccagg aacuucgcag aacacucaag gagguccuga ccugcagcug guga            954


<210>  2540
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR95

<400>  2540

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Arg Ser Trp 
305                 310                 315         


<210>  2541
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62974

<400>  2541
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga cacgcuccug guga            954


<210>  2542
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62974

<400>  2542
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga cccgcagcug guga            954


<210>  2543
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62974

<400>  2543
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca cccgcuccug guga            954


<210>  2544
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62974

<400>  2544
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gagguacuga cgagguccug guga            954


<210>  2545
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62974

<400>  2545
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccagaagcug guga            954


<210>  2546
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62974

<400>  2546
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga cccggagcug guga            954


<210>  2547
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR96

<400>  2547

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Met Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2548
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62973

<400>  2548
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gaugcucaag gaggugcuga caugcuccug guga            954


<210>  2549
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62973

<400>  2549
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gaugcucaag gaggugcuga ccugcagcug guga            954


<210>  2550
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62973

<400>  2550
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg caugcucaag gagguccuca ccugcuccug guga            954


<210>  2551
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62973

<400>  2551
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aaugcucaag gagguacuga ccugcuccug guga            954


<210>  2552
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62973

<400>  2552
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aaugcugaag gaggugcuga ccugcagcug guga            954


<210>  2553
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62973

<400>  2553
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aaugcucaag gaggugcuga caugcagcug guga            954


<210>  2554
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR97

<400>  2554

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Trp Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2555
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62972

<400>  2555
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggccuggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2556
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62972

<400>  2556
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgccuggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2557
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62972

<400>  2557
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgccuggg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2558
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62972

<400>  2558
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuuggg ccugucagca cgcacagggg      660

aucgccagac uccauaaaag gcagcggccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2559
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62972

<400>  2559
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccuggg ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2560
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62972

<400>  2560
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcuuggg ccugucagca cgcccagggc      660

aucgcucggc uccauaaacg ccagagaccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2561
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR98

<400>  2561

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Gln 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2562
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62971

<400>  2562
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcag      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2563
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62971

<400>  2563
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccag      480

gcccggcgcg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2564
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62971

<400>  2564
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccag      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2565
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62971

<400>  2565
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgcag      480

gccaggcggg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcucgcg ccugucagca cgcacagggg      660

aucgccagac uccauaaaag gcaacggccc gugcaccagg gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2566
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62971

<400>  2566
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugccccag      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2567
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62971

<400>  2567
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccag      480

gcccggcgcg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcuagag ccugucagca cgcccagggc      660

aucgcucggc uccauaaacg ccaaagaccu guucaccagg gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2568
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6UR99

<400>  2568

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Leu Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2569
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62970

<400>  2569
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuuguugg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2570
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62970

<400>  2570
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugcugg accuccuggu gagcggcucc aacguccugg agaccgccgu gauccuccug      300

cuggaggccg gcgcgcucgu ggcccgcgcc gccguccugc agcagcugga caacgugauc      360

gacgugauca cgugcagcuc caugcucagc ucccugugcu uccugggggc caucgcgguc      420

gaccgguaca ucagcaucuu cuacgcccuc cgcuaccacu ccaucgugac ccugccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccagcgugg uguucuccac ccuguucauc      540

gccuacuacg accacgucgc cgugcuccug ugccuggugg ucuucuuccu cgccaugcug      600

gugcugaugg cggugcucua cguccacaug cuggcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu caagggggcg      720

gucacccuga ccauccugcu cggcaucuuc uuccugugcu ggggcccguu cuuccugcac      780

cucacgcuga ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccucuucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcuccgccg gacccugaag gaggugcuga ccugcuccug guga            954


<210>  2571
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62970

<400>  2571
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccuccucg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2572
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62970

<400>  2572
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugcugg aucucuuagu cucgggauca aaugugcugg agaccgcugu uauucuuuug      300

cuggaagcag gcgcccuagu ggcucgagcc gcgguccucc agcaacugga caacgugauc      360

gauguaauua caugcagcag uaugcuuucc ucucuguguu ucuugggugc aaucgccguu      420

gaccguuaua uaagcaucuu uuacgcucuc agauaucauu ccauugugac ucugccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgucagugg ucuucaguac cuuauuuauu      540

gccuacuaug aucacguugc agugcugcuc ugccuuguag uguucuuucu ggcuauguug      600

guccuaaugg ccgugcugua cguucauaug cucgcuagag ccugucagca cgcacagggg      660

aucgccaggc ugcauaaacg gcagcgcccc gugcaccaag gauucggccu uaagggcgcu      720

gucacacuga ccauauugcu cgggaucuuu uuccugugcu ggggaccauu uuucuuacac      780

cugacucuaa uugugcucug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccuguucc uugcguugau caucugcaau gcaauuauag acccucugau cuaugccuuu      900

cacagccagg aacuccgaag aacccugaag gagguacuua cgugcucuug guga            954


<210>  2573
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62970

<400>  2573
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugcugg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2574
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62970

<400>  2574
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuucugg aucuccuggu gucuggcagc aauguucuug agacagcugu gauccugcuc      300

cuggaagccg gggcgcuggu cgcccgggcu gccgugcucc agcaacugga caacguuauu      360

gaugugauua ccugcuccag caugcuuucu ucccuguguu uccucggagc uaucgccguc      420

gaccgcuaua ucagcaucuu uuacgcgcug agauaucauu cuauugugac acuuccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccuccguug uguucagcac ccuguuuauu      540

gccuacuaug aucacguggc uguccuccug ugccuggugg uuuucuuucu cgcgaugcug      600

gugcuuaugg ccguccugua cgugcauaug cucgcucggg ccugucagca cgcccagggc      660

aucgcucgcc ugcauaaaag acagcggccu guucaccaag gcuucgggcu uaagggagcc      720

gugacacuga ccauucuccu gggcaucuuu uuccugugcu gggggcccuu uuuccuccac      780

cugacgcuua ucguccugug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccucuucc uggcgcugau cauuugcaau gcuaucauug acccccuuau cuaugccuuu      900

cacucucagg aacuccgcag aacacugaag gaggugcuga ccugcuccug guga            954


<210>  2575
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q6URA0

<400>  2575

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Leu Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2576
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAQ62969

<400>  2576
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc uccuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2577
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAQ62969

<400>  2577
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc ugcuccuguc ccuggggcuc gugagccugg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccuccac ucccccaugu acugcuucau cugcugccug      240

gcccugagcg accuccuggu guccggcagc aacguccugg agaccgccgu gauccuccug      300

cuggaggccg gcgcgcucgu ggcccgcgcc gccguccugc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcucucc agccugugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccuc cgcuaccaca gcaucgugac ccugccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcuccug ugccuggugg ucuucuuccu cgccaugcug      600

gugcugaugg cggugcucua cguccacaug cuggcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu caagggggcg      720

gucacccuga ccauccugcu cggcaucuuc uuccugugcu ggggcccguu cuuccugcac      780

cucacgcuga ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccucuucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcuccgccg gacccugaag gaggugcuga ccugcagcug guga            954


<210>  2578
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAQ62969

<400>  2578
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc uccuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2579
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAQ62969

<400>  2579
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc ugcuacucag ccuggggcuu guuucccugg uggaaaacgc uuugguagug      180

gccacgauag caaagaaucg caaccuccac ucuccaaugu acuguuucau cugcugucug      240

gcccugucgg aucucuuagu cucaggaagc aaugugcugg agaccgcugu uauucuuuug      300

cuggaagcag gcgcccuagu ggcucgagcc gcgguccucc agcaacugga caacgugauc      360

gauguaauua caugcaguuc caugcuuucu agccugugcu uuuugggugc aaucgccguu      420

gaccguuaua uauccaucuu cuacgcucuc agauaucauu caauugugac ucugccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuuuagcac cuuauucauu      540

gccuacuaug aucacguugc agugcugcuc ugucuuguag uguuuuuccu ggcuauguug      600

guccuaaugg ccgugcugua cguucauaug cucgcuagag ccugucagca cgcacagggg      660

aucgccaggc ugcauaaacg gcagcgcccc gugcaccaag gauuuggccu uaagggcgcu      720

gucacacuga ccauauugcu cgggauuuuc uuucugugcu ggggaccuuu cuuuuuacac      780

cugacucuaa ucgugcucug uccagagcau cccacaugcg guuguauuuu caaaaauuuu      840

aaccuguucc uugcguugau caucugcaau gcaauuauag acccucugau cuaugccuuc      900

cacucucagg aacuccgaag aacccugaag gagguacuua cgugcuccug guga            954


<210>  2580
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAQ62969

<400>  2580
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc ugcugcugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2581
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAQ62969

<400>  2581
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc ugcuucuguc ucucggacug guuagccugg uggaaaacgc ccucgugguc      180

gccaccaucg cuaagaauag aaaccugcac uccccgaugu acuguuucau uugcugucuu      240

gcccugucug aucuccuggu gagcggcucc aauguucuug agacagcugu gauccugcuc      300

cuggaagccg gggcgcuggu cgcccgggcu gccgugcucc agcaacugga caacguuauu      360

gaugugauua ccugcagcuc uaugcuuucc agccuguguu uucucggagc uaucgccguc      420

gaccgcuaua ucucuaucuu cuacgcgcug agauaucauu ccauugugac acuuccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguuuucuac ccuguucauu      540

gccuacuaug aucacguggc uguccuccug ugccuggugg uguuuuuccu cgcgaugcug      600

guucuuaugg ccguccugua cgugcauaug cucgcucggg ccugucagca cgcccagggc      660

aucgcucgcc ugcauaaaag acagcggccu guucaccaag gcuuugggcu uaagggagcc      720

gugacacuga ccauucuccu gggcaucuuc uuucugugcu gggggcccuu cuuucuccac      780

cugacgcuua ucguccugug uccugagcau ccuaccugcg gauguauuuu caaaaauuuu      840

aaccucuucc uggcgcugau cauuugcaau gcuaucauug acccccuuau cuaugccuuc      900

cacucccagg aacuccgcag aacacugaag gaggugcuga ccugcagcug guga            954


<210>  2582
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__Q86YW1

<400>  2582

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Arg Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2583
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AAO21073

<400>  2583
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcggg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2584
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AAO21073

<400>  2584
auggccgugc agggcagcca gcgccggcuc cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccgcg agaccgccgu gauccugcug      300

cucgaggccg gcgcgcuggu ggcccgggcc gccguccugc agcagcucga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccugugcu uccucggggc caucgcgguc      420

gaccgcuaca ucuccaucuu cuacgcccug cgguaccaca gcaucgugac ccugccccgc      480

gcccggcgcg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccucuucauc      540

gccuacuacg accacgucgc cgugcugcug ugccucgugg ucuucuuccu ggccaugcug      600

gugcucaugg cggugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuga ccauccuccu gggcaucuuc uuccugugcu ggggcccguu cuuccuccac      780

cugacgcuga ucgugcucug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc uggcccucau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccugaag gaggugcuga ccugcagcug guga            954


<210>  2585
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AAO21073

<400>  2585
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccgcg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2586
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AAO21073

<400>  2586
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aaugugcgag agaccgcugu uauuuuacug      300

cuugaagcag gcgccuuggu ggcucgugcc gcgguccugc agcaacuaga caacgugauc      360

gauguaauua caugcaguuc caugcucucu agccuguguu uccuuggugc aaucgccguu      420

gacagauaua uauccaucuu uuacgcucug agguaucauu caauugugac uuugccgcgg      480

gcccgcagag cagucgcugc caucugggug gcgagugugg ucuucagcac ccucuuuauu      540

gccuacuaug aucacguugc agugcuguua ugccugguag uguucuuucu cgcuaugcuu      600

guccugaugg ccguguugua cguucauaug cuagcuaggg ccugucagca cgcacagggg      660

aucgcccggc ugcauaaacg ccagcgaccc gugcaccaag gauucggccu caagggcgcu      720

gucacacuga ccauacuucu ggggaucuuu uucuugugcu ggggaccauu uuuccuccac      780

cugacuuuaa uugugcugug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccuauucc ucgcgcugau caucugcaau gcaauuauag acccucuuau cuaugccuuu      900

cacucucagg aauugagaag gacccugaag gagguacuca cgugcuccug guga            954


<210>  2587
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AAO21073

<400>  2587
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugagag agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2588
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AAO21073

<400>  2588
auggccgugc agggcagcca aagacggcuc cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucggg agacagcugu gauccugcuu      300

cuggaagccg gggcgcucgu cgcccgcgcu gccgugcugc agcaacugga caacguuauu      360

gaugugauua ccugcagcuc uaugcucucc agccuguguu uccuuggagc uaucgccguc      420

gacagauaua ucucuaucuu uuacgcgcug cgguaucauu ccauugugac acucccccgc      480

gccagacggg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuguuuauu      540

gccuacuaug aucacguggc uguccuucug ugccucgugg uuuucuuucu ggcgaugcug      600

gugcucaugg ccguccugua cgugcauaug cuugcucgcg ccugucagca cgcccagggc      660

aucgcuagac ugcauaaacg gcagcgcccu guucaccaag gcuucgggcu caagggagcc      720

gugacacuga ccauucuucu gggcaucuuu uuccucugcu gggggcccuu uuuccugcac      780

cugacgcuca ucguccugug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuuuucc uggcgcucau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacugagacg gacacuuaag gaggugcuga ccugcagcug guga            954


<210>  2589
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q5S2

<400>  2589

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Pro Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2590
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09567

<400>  2590
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugccgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2591
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09567

<400>  2591
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccgcagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugcccg accugcucgu gagcggcucc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcagcuc caugcugagc ucccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucagcaucuu cuacgcccug cgcuaccacu ccaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccagcgugg uguucuccac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccg gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggccccuu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugcgccg gacccucaag gaggugcuga ccugcuccug guga            954


<210>  2592
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09567

<400>  2592
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccuccccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2593
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09567

<400>  2593
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugccgg aucugcucgu cucgggauca aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcagcag uaugcugucc ucucuuuguu uccugggugc aaucgccguu      420

gaccguuaua uaagcaucuu uuacgcuuug agauaucauu ccauugugac ucuccccagg      480

gcccggcgcg cagucgcugc caucugggug gcgucagugg ucuucaguac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccu gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug ucccgagcau ccuacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccauugau cuaugccuuu      900

cacagccagg aacugcgaag aacccucaag gagguacuga cgugcucuug guga            954


<210>  2594
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09567

<400>  2594
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugcccg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2595
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09567

<400>  2595
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuucccg aucugcucgu gucuggcagc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcuccag caugcugucu ucccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucagcaucuu uuacgcgcuc agauaucauu cuauugugac acugccucgg      480

gcccgcagag cuguggccgc uaucuggguc gccuccguug uguucagcac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccc guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccgcugau cuaugccuuu      900

cacucucagg aacuucgcag aacacucaag gaggugcuga ccugcuccug guga            954


<210>  2596
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q671

<400>  2596

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Met Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2597
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09812

<400>  2597
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucaugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2598
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09812

<400>  2598
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccugaugg uguucuuccu ggccaugcuc      600

guccugaugg cggugcugua cgugcacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu gaagggggcg      720

gugacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucguccugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2599
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09812

<400>  2599
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucaugg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2600
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09812

<400>  2600
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucaugg uauucuuucu ugcuaugcug      600

guguugaugg ccguccuaua cgugcauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc guucaccaag gauucggccu gaagggcgcu      720

gugacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uuguccuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gaggugcuga cgugcuccug guga            954


<210>  2601
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09812

<400>  2601
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccugaugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2602
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09812

<400>  2602
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccugaugg uguucuuucu ggcgaugcuc      600

guucugaugg ccgugcuuua cguccauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu gugcaccaag gcuucgggcu gaagggagcc      720

guuacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucgugcuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gagguccuga ccugcagcug guga            954


<210>  2603
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q783

<400>  2603

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Thr Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2604
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10192

<400>  2604
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

accgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2605
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10192

<400>  2605
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

accgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca cgauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacccuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga cgugcagcug guga            954


<210>  2606
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10192

<400>  2606
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

accgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2607
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10192

<400>  2607
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

acagccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacccuua cuauccuguu ggggauauuu uuccucugcu ggggacccuu uuuccugcac      780

uuaacacuga uugugcuaug uccagagcau ccuaccugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau uaucugcaau gcaaucauug acccuuugau auaugccuuu      900

cacucucagg aacugcgaag aacgcucaag gagguacuga cuugcuccug guga            954


<210>  2608
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10192

<400>  2608
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

accgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2609
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10192

<400>  2609
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua uuucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

acagcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacccuua cgauccugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacccuga ucguccuuug uccugagcau cccacaugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccucugau uuaugccuuu      900

cacucccagg aacuucgcag aacccucaag gaggugcuga caugcagcug guga            954


<210>  2610
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q7F1

<400>  2610

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Thr Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2611
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09641

<400>  2611
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaccgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga cgugcuccug guga            954


<210>  2612
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09641

<400>  2612
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaccgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca cgauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacccuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga cgugcagcug guga            954


<210>  2613
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09641

<400>  2613
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaccgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2614
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09641

<400>  2614
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caacugugac ccucccgagg      480

gcccggcgcg cagucgcugc cauuugggug gcgagugugg ucuucagcac acuguuuauc      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

auugccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacccuua cuauccuguu ggggauauuu uuccucugcu ggggacccuu uuuccugcac      780

uuaacacuga uugugcuaug uccagagcau ccuaccugcg guuguaucuu uaaaaauuuc      840

aaccucuucc uggcgcuuau uaucugcaau gcaaucauug acccuuugau auaugccuuu      900

cacucucagg aacugcgaag aacgcucaag gagguacuga cuugcuccug guga            954


<210>  2615
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09641

<400>  2615
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaccgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2616
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09641

<400>  2616
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua uuucuaucuu uuacgcgcuc agauaucauu ccacagugac ccugccccgg      480

gcccgcagag cuguggccgc uauuuggguc gccagcguug uguucucuac acuuuuuauc      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

auugcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacccuua cgauccugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacccuga ucguccuuug uccugagcau cccacaugcg gauguaucuu uaaaaauuuc      840

aaccuguucc ucgcgcugau uaucugcaau gcuauuaucg acccucugau uuaugccuuu      900

cacucccagg aacuucgcag aacccucaag gaggugcuga caugcagcug guga            954


<210>  2617
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q8N1

<400>  2617

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Tyr Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2618
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10044

<400>  2618
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc gguaccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2619
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10044

<400>  2619
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcuaccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2620
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10044

<400>  2620
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcuaccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2621
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10044

<400>  2621
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc gguacuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu auugcuuuau cuguugccuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua cauguaguuc caugcugucu agccuuugcu uccugggugc aaucgccguu      420

gaccguuaca uauccaucuu uuaugcuuug agauaccauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuauuacg aucacguugc aguguuacug ugucucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua uguucauaug cuggcuagag ccugccagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucuguu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug cccugagcau cccacaugug guugcauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucuguaau gcaauuauag acccuuugau cuacgccuuu      900

cacucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2622
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10044

<400>  2622
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gauaccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2623
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10044

<400>  2623
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcuaccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu auugcuuuau uuguugccug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauca ccuguagcuc uaugcugucc agccuuugcu uccugggagc uaucgccguc      420

gaccgcuaca uuucuaucuu uuaugcgcuc agauaccauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuauuacg aucacguggc uguccugcuc ugucuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua ugugcauaug cuggcucggg ccugccagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccuguguu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug cccugagcau cccaccugug gaugcauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuuguaau gcuaucauug acccucugau cuacgccuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2624
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q977

<400>  2624

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Leu Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2625
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09532

<400>  2625
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguguug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2626
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09532

<400>  2626
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccugguccug      180

gccaccaucg cgaagaaccg gaaccuccac ucccccaugu acugcuucau cugcugccug      240

gcccugagcg accuccuggu guccggcagc aacgugcugg agaccgccgu cauccuccug      300

cuggaggccg gcgcgcucgu ggcccgcgcc gccgugcugc agcagcugga caacgucauc      360

gacgugauca cgugcuccag caugcucucc agccugugcu uccugggggc caucgcggug      420

gaccgguaca ucuccaucuu cuacgcccuc cgcuaccaca gcaucgucac ccugccccgg      480

gcccgccggg ccguggccgc gaucugggug gccuccgucg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cguccuccug ugccuggugg uguucuuccu cgccaugcug      600

guccugaugg cggugcucua cgugcacaug cuggcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu caagggggcg      720

gugacccuga ccauccugcu cggcaucuuc uuccugugcu ggggcccguu cuuccugcac      780

cucacgcuga ucguccugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccucuucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcuccgccg gacccugaag gaggugcuga ccugcagcug guga            954


<210>  2627
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09532

<400>  2627
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucguccuc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2628
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09532

<400>  2628
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguauug      180

gccacgauag caaagaaucg caaccuccac ucuccaaugu acuguuuuau cugcugucug      240

gcccugucgg aucucuuagu gucaggaagc aauguccugg agaccgcugu gauucuuuug      300

cuggaagcag gcgcccuagu ugcucgagcc gcggugcucc agcaacugga caacgucauc      360

gaugugauua caugcaguuc caugcuuucu agccuguguu ucuugggugc aaucgccgua      420

gaccguuaua uauccaucuu uuacgcucuc agauaucauu caauuguuac ucugccgagg      480

gcccggcgcg caguggcugc caucuggguc gcgagugugg uguucagcac cuuauuuauu      540

gccuacuaug aucacgucgc aguucugcuc ugccuugugg uauucuuucu ggcuauguug      600

gugcuaaugg ccguccugua cgugcauaug cucgcuagag ccugucagca cgcacagggg      660

aucgccaggc ugcauaaacg gcagcgcccc guucaccaag gauucggccu uaagggcgcu      720

gugacacuga ccauauugcu cgggaucuuu uuccugugcu ggggaccauu uuucuuacac      780

cugacucuaa uuguccucug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccuguucc uugcguugau caucugcaau gcaauuauag acccucugau cuaugccuuu      900

cacucucagg aacuccgaag aacccugaag gaggugcuua cgugcuccug guga            954


<210>  2629
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09532

<400>  2629
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccuggugcug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2630
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09532

<400>  2630
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugcuc      180

gccaccaucg cuaagaauag aaaccugcac uccccgaugu acuguuuuau uugcugucuu      240

gcccugucug aucuccuggu cagcggcucc aaugugcuug agacagcugu uauccugcuc      300

cuggaagccg gggcgcuggu ggcccgggcu gccguccucc agcaacugga caacgugauu      360

gauguuauua ccugcagcuc uaugcuuucc agccuguguu uccucggagc uaucgccgug      420

gaccgcuaua ucucuaucuu uuacgcgcug agauaucauu ccauugucac acuuccccgg      480

gcccgcagag cuguggccgc uaucugggug gccagcgucg uuuucucuac ccuguuuauu      540

gccuacuaug aucacguggc ugugcuccug ugccuggucg uguucuuucu cgcgaugcug      600

guucuuaugg ccgugcugua cguccauaug cucgcucggg ccugucagca cgcccagggc      660

aucgcucgcc ugcauaaaag acagcggccu gugcaccaag gcuucgggcu uaagggagcc      720

guuacacuga ccauucuccu gggcaucuuu uuccugugcu gggggcccuu uuuccuccac      780

cugacgcuua ucgugcugug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccucuucc uggcgcugau cauuugcaau gcuaucauug acccccuuau cuaugccuuu      900

cacucccagg aacuccgcag aacacugaag gagguccuga ccugcagcug guga            954


<210>  2631
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q9P5

<400>  2631

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Pro Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2632
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC11042

<400>  2632
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

cccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2633
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC11042

<400>  2633
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccgcagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

ccccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcccuggu ggcgcgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgccguc      420

gaccgguaca ucuccaucuu cuacgcgcug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc caucuggguc gcguccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg ccgugcugua cguccacaug cucgcgcgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccg gugcaccagg gguucggccu gaagggggcc      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggccccuu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcgcugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2634
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC11042

<400>  2634
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

ccccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2635
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC11042

<400>  2635
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

ccgcugucgg aucugcucgu cucaggaagc aauguguuag agaccgccgu uauucugcuu      300

uuggaagcug gcgcacuggu ggcccgagcu gccguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc gaucgcaguu      420

gaccguuaua uauccaucuu uuacgccuug agauaucauu caauugugac ucuccccagg      480

gcucggcgcg ccgucgcagc uaucugggug gccagugugg ucuucagcac ccuguuuauu      540

gcguacuaug aucacguugc cguguuacug ugccucguag uguucuuucu ugcaaugcug      600

gucuugaugg cugugcuaua cguucauaug cuggccagag cuugucagca cgcccagggg      660

aucgcaaggc uccauaaacg gcagcgcccu gugcaccaag gauucggccu gaagggcgcc      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug ucccgagcau ccuacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcucuuau caucugcaau gcgauuauag acccauugau cuaugcauuu      900

cacucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2636
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC11042

<400>  2636
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

ccccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2637
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC11042

<400>  2637
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

ccccuuucug aucugcucgu gagcggcucc aauguucugg agacagccgu gauccuucug      300

cucgaagcug gggcccuggu cgcgcgggcc gcugugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc caucgcuguc      420

gaccgcuaua ucucuaucuu uuacgcccuc agauaucauu ccauugugac acugccucgg      480

gcgcgcagag ccguggcugc caucuggguc gcuagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc cguccugcuc ugccuggugg uuuucuuucu ggcuaugcuc      600

gugcugaugg cgguccuuua cgugcauaug cuggcccggg cuugucagca cgcccagggc      660

aucgcccgcc uccauaaaag acagcggccc guucaccaag gcuucgggcu gaagggagcu      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcccugau cauuugcaau gcgaucauug acccgcugau cuaugcuuuu      900

cacucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2638
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9Q9R8

<400>  2638

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Ser Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2639
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10733

<400>  2639
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

agccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2640
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10733

<400>  2640
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

ucccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2641
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10733

<400>  2641
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

ucccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2642
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10733

<400>  2642
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

ucucucuucc uggcgcuuau caucugcaac gcaauuauag acccuuugau cuaugccuuu      900

cacucccagg aacugcgaag aacccucaag gagguacuga cgugcucaug guga            954


<210>  2643
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10733

<400>  2643
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

agccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2644
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10733

<400>  2644
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

ucccuguucc ucgcgcugau cauuugcaac gcuaucauug acccccugau cuaugccuuu      900

cacagccagg aacuucgcag aacacucaag gaggugcuga ccugcuccug guga            954


<210>  2645
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QAE0

<400>  2645

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile His Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2646
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10696

<400>  2646
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau ccacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2647
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10696

<400>  2647
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau ccacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2648
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10696

<400>  2648
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau ccacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2649
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10696

<400>  2649
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau ccacgccuuu      900

cauucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2650
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10696

<400>  2650
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau ccacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2651
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10696

<400>  2651
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau ccacgccuuu      900

cauucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2652
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QAR2

<400>  2652

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile His Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2653
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09527

<400>  2653
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucc acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2654
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09527

<400>  2654
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucc acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2655
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09527

<400>  2655
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucc acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2656
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09527

<400>  2656
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauac acccuuugau cuaugccuuu      900

cauucucagg aacugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2657
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09527

<400>  2657
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucc acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2658
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09527

<400>  2658
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauuc acccccugau cuaugccuuu      900

cauucccagg aacuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2659
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QAW3

<400>  2659

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln His Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2660
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10869

<400>  2660
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcacccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2661
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10869

<400>  2661
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcacccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2662
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10869

<400>  2662
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcacccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2663
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10869

<400>  2663
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcacccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcau      780

uuaacucuga uugugcuaug uccugagcac cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cauucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2664
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10869

<400>  2664
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagcacccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2665
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10869

<400>  2665
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcacccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcau      780

cucacgcuga ucguccuuug uccugagcac ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cauucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2666
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QB02

<400>  2666

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Thr Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2667
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC11615

<400>  2667
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucacccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2668
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC11615

<400>  2668
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucacccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga cgugcagcug guga            954


<210>  2669
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC11615

<400>  2669
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucacccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2670
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC11615

<400>  2670
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc ugacccuuau caucugcaau gcgauuauag acccuuugau cuaugcauuu      900

cacucucagg aacugcgaag aacgcucaag gagguacuga cuugcuccug guga            954


<210>  2671
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC11615

<400>  2671
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc ugacccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2672
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC11615

<400>  2672
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucacacugau cauuugcaau gcgaucauug acccccugau cuaugcuuuu      900

cacucccagg aacuucgcag aacccucaag gaggugcuga caugcagcug guga            954


<210>  2673
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QB58

<400>  2673

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp His Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2674
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09535

<400>  2674
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccacuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2675
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09535

<400>  2675
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccacuaca ucuccaucuu cuacgcccug cgguaccaca gcaucgugac ccucccccgc      480

gcccggcgcg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2676
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09535

<400>  2676
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccacuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2677
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09535

<400>  2677
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccauuaua uauccaucuu uuacgcuuug cguuaucacu caauugugac ucucccgaga      480

gccaggcggg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucauguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucacaug cuggcucgcg ccugucagca ugcacagggg      660

aucgccagac uccacaaaag gcagcggccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcau      780

uuaacucuga uugugcuaug uccugagcac cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cauucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2678
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09535

<400>  2678
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gaccacuaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2679
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09535

<400>  2679
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccauuaua ucucuaucuu uuacgcgcuc cgcuaucacu ccauugugac acugcccaga      480

gcccggcgcg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucauguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcacaug cuggcuagag ccugucagca ugcccagggc      660

aucgcucggc uccacaaacg ccagagaccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcau      780

cucacgcuga ucguccuuug uccugagcac ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cauucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2680
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QBY6

<400>  2680

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Asn Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2681
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC11840

<400>  2681
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacaaccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2682
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC11840

<400>  2682
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacaaccagg agcugcgccg gacccucaag gaggugcuga ccugcuccug guga            954


<210>  2683
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC11840

<400>  2683
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacaaccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2684
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC11840

<400>  2684
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacaaccagg aacugcgaag aacccucaag gagguacuga cgugcucuug guga            954


<210>  2685
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC11840

<400>  2685
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacaaccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2686
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC11840

<400>  2686
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacaaccagg aacuucgcag aacacucaag gaggugcuga ccugcuccug guga            954


<210>  2687
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QC17

<400>  2687

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Met Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2688
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09665

<400>  2688
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacaugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2689
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09665

<400>  2689
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacaugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcggug      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgucac ccucccccgg      480

gcccgccggg ccguggccgc gaucugggug gccuccgucg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cguccugcuc ugccuggugg uguucuuccu ggccaugcuc      600

guccugaugg cggugcugua cgugcacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc guccaccagg gguucggccu gaagggggcg      720

gugacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucguccugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2690
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09665

<400>  2690
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacaugauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2691
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09665

<400>  2691
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauaugauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccgua      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauuguuac ucucccgagg      480

gcccggcgcg caguggcugc caucuggguc gcgagugugg uguucagcac ccuguuuauu      540

gccuacuaug aucacgucgc aguuuuacug ugccucgugg uauucuuucu ugcuaugcug      600

guguugaugg ccguccuaua cgugcauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc guucaccaag gauucggccu gaagggcgcu      720

gugacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uuguccuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgaag aacccucaag gaggugcuga cgugcuccug guga            954


<210>  2692
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09665

<400>  2692
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacaugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2693
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09665

<400>  2693
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gauaugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccgug      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugucac acugccccgg      480

gcccgcagag cuguggccgc uaucugggug gccagcgucg uuuucucuac ccuuuuuauu      540

gccuacuaug aucacguggc ugugcugcuc ugccuggucg uguucuuucu ggcgaugcuc      600

guucugaugg ccgugcuuua cguccauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu gugcaccaag gcuucgggcu gaagggagcc      720

guuacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucgugcuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucgcag aacacucaag gagguccuga ccugcagcug guga            954


<210>  2694
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QC66

<400>  2694

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Arg Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2695
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC11324

<400>  2695
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau cauccgcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2696
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC11324

<400>  2696
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau cauccgcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2697
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC11324

<400>  2697
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau cauccgcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2698
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC11324

<400>  2698
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau cauccgaaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugagaag gacccucaag gagguacuga cgugcuccug guga            954


<210>  2699
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC11324

<400>  2699
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucagaaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2700
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC11324

<400>  2700
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauucgcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuuagacg gacacucaag gaggugcuga ccugcagcug guga            954


<210>  2701
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QCQ4

<400>  2701

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Trp 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2702
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09521

<400>  2702
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgugg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2703
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09521

<400>  2703
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccuccccugg      480

gcccggcgcg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2704
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09521

<400>  2704
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccuccccugg      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2705
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09521

<400>  2705
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgugg      480

gccaggcggg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcucgcg ccugucagca cgcacagggg      660

aucgccagac uccauaaaag gcagcggccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cgugcuccug guga            954


<210>  2706
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09521

<400>  2706
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccugg      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2707
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09521

<400>  2707
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugcccugg      480

gcccggcgcg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcuagag ccugucagca cgcccagggc      660

aucgcucggc uccauaaacg ccagagaccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccccugau cuaugccuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccugcagcug guga            954


<210>  2708
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QDF4

<400>  2708

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Glu 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2709
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC11794

<400>  2709
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccgagugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2710
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC11794

<400>  2710
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccgcagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac cccgagugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2711
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC11794

<400>  2711
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccgagugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2712
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC11794

<400>  2712
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugagcau cccgaaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg agcugcgaag aacacucaag gagguacuga ccugcuccug guga            954


<210>  2713
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC11794

<400>  2713
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccgagugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2714
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC11794

<400>  2714
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugagcau cccgaaugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccucugau cuaugccuuu      900

cacucccagg agcuucgcag aacccucaag gaggugcuga caugcagcug guga            954


<210>  2715
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QDN7

<400>  2715

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Glu Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2716
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC10874

<400>  2716
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg aacugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug cgcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2717
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC10874

<400>  2717
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg agcugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug cgcuaccaca gcaucgugac ccucccccgg      480

gcccgccggg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccggc ugcacaagcg ccagcggccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcgccg gacccucaag gaggugcuga ccugcagcug guga            954


<210>  2718
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC10874

<400>  2718
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg agcuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc cgcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2719
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC10874

<400>  2719
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg agcugcucgu cucaggaagc aauguguuag aaaccgcugu uauucugcuu      300

uuggaggcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga uaacgugauc      360

gacguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaucguuaua uauccaucuu uuacgcuuug agauaucauu caauugugac ucucccgagg      480

gcccggcgcg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug accacguugc aguguuacug ugccucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcuagag ccugucagca cgcacagggg      660

aucgccaggc uccauaaacg gcagcgcccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucugcu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug uccugaacau cccacaugcg guuguauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag auccuuugau cuaugccuuu      900

cacucucagg agcugcgaag aacccucaag gagguacuga cgugcuccug guga            954


<210>  2720
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC10874

<400>  2720
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg agcugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug agauaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2721
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC10874

<400>  2721
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug agcugcucgu gagcggcucc aauguucugg aaacagcugu gauccuucug      300

cucgaggccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga uaacguuauu      360

gacgugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaucgcuaua ucucuaucuu uuacgcgcuc agauaucauu ccauugugac acugccccgg      480

gcccgcagag cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug accacguggc uguccugcuc ugccuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcucggg ccugucagca cgcccagggc      660

aucgcucgcc uccauaaaag acagcggccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccugugcu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug uccugaacau ccuaccugcg gauguauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug auccccugau cuaugccuuu      900

cacucccagg agcuucgcag aacacucaag gaggugcuga ccugcagcug guga            954


<210>  2722
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__V9QDQ6

<400>  2722

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Cys Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  2723
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MC1_R__Homo_sapiens__AHC09597

<400>  2723
auggcugugc agggauccca gagaagacuu cugggcuccc ucaacuccac ccccacagcc       60

aucccccagc uggggcuggc ugccaaccag acaggagccc ggugccugga gguguccauc      120

ucugacgggc ucuuccucag ccuggggcug gugagcuugg uggagaacgc gcugguggug      180

gccaccaucg ccaagaaccg gaaccugcac ucacccaugu acugcuucau cugcugccug      240

gccuugucgg accugcuggu gagcgggagc aacgugcugg agacggccgu cauccuccug      300

cuggaggccg gugcacuggu ggcccgggcu gcggugcugc agcagcugga caaugucauu      360

gacgugauca ccugcagcuc caugcugucc agccucugcu uccugggcgc caucgccgug      420

gaccgcuaca ucuccaucuu cuacgcacug ugcuaccaca gcaucgugac ccugccgcgg      480

gcgcggcgag ccguugcggc caucugggug gccagugucg ucuucagcac gcucuucauc      540

gccuacuacg accacguggc cguccugcug ugccucgugg ucuucuuccu ggcuaugcug      600

gugcucaugg ccgugcugua cguccacaug cuggcccggg ccugccagca cgcccagggc      660

aucgcccggc uccacaagag gcagcgcccg guccaccagg gcuuuggccu uaaaggcgcu      720

gucacccuca ccauccugcu gggcauuuuc uuccucugcu ggggccccuu cuuccugcau      780

cucacacuca ucguccucug ccccgagcac cccacgugcg gcugcaucuu caagaacuuc      840

aaccucuuuc ucgcccucau caucugcaau gccaucaucg acccccucau cuacgccuuc      900

cacagccagg agcuccgcag gacgcucaag gaggugcuga caugcuccug guga            954


<210>  2724
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MC1_R__Homo_sapiens__AHC09597

<400>  2724
auggccgugc agggcagcca gcgccggcug cucggguccc ugaacagcac ccccaccgcc       60

aucccccagc ugggccucgc ggccaaccag acgggggccc gcugccugga ggucuccauc      120

agcgacggcc uguuccucuc ccuggggcug gugagccucg uggagaacgc ccuggucgug      180

gccaccaucg cgaagaaccg gaaccugcac ucccccaugu acugcuucau cugcugccuc      240

gcccugagcg accugcucgu guccggcagc aacguccugg agaccgccgu gauccugcuc      300

cuggaggccg gcgcgcuggu ggcccgcgcc gccguccucc agcagcugga caacgugauc      360

gacgugauca cgugcuccag caugcugucc agccucugcu uccugggggc caucgcgguc      420

gaccgguaca ucuccaucuu cuacgcccug ugcuaccaca gcaucgugac ccucccccgc      480

gcccggcgcg ccguggccgc gaucuggguc gccuccgugg uguucagcac ccuguucauc      540

gccuacuacg accacgucgc cgugcugcuc ugccuggugg ucuucuuccu ggccaugcuc      600

gugcugaugg cggugcugua cguccacaug cucgcccggg ccugccagca cgcccagggc      660

aucgcccgcc ugcacaagcg gcagcgcccc gugcaccagg gguucggccu gaagggggcg      720

gucacccuca ccauccugcu gggcaucuuc uuccucugcu ggggcccguu cuuccugcac      780

cugacgcuca ucgugcugug ccccgagcac ccgaccugcg ggugcaucuu caagaacuuc      840

aaccuguucc ucgcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacucccagg agcugcggcg cacccucaag gaggugcuga ccugcagcug guga            954


<210>  2725
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MC1_R__Homo_sapiens__AHC09597

<400>  2725
auggccgucc agggcuccca gcgccgccuc cucggcuccc ucaacuccac ccccaccgcc       60

aucccccagc ucggccucgc cgccaaccag accggcgccc gcugccucga ggucuccauc      120

uccgacggcc ucuuccucuc ccucggccuc gucucccucg ucgagaacgc ccucgucguc      180

gccaccaucg ccaagaaccg caaccuccac ucccccaugu acugcuucau cugcugccuc      240

gcccucuccg accuccucgu cuccggcucc aacguccucg agaccgccgu cauccuccuc      300

cucgaggccg gcgcccucgu cgcccgcgcc gccguccucc agcagcucga caacgucauc      360

gacgucauca ccugcuccuc caugcucucc ucccucugcu uccucggcgc caucgccguc      420

gaccgcuaca ucuccaucuu cuacgcccuc ugcuaccacu ccaucgucac ccucccccgc      480

gcccgccgcg ccgucgccgc caucuggguc gccuccgucg ucuucuccac ccucuucauc      540

gccuacuacg accacgucgc cguccuccuc ugccucgucg ucuucuuccu cgccaugcuc      600

guccucaugg ccguccucua cguccacaug cucgcccgcg ccugccagca cgcccagggc      660

aucgcccgcc uccacaagcg ccagcgcccc guccaccagg gcuucggccu caagggcgcc      720

gucacccuca ccauccuccu cggcaucuuc uuccucugcu ggggccccuu cuuccuccac      780

cucacccuca ucguccucug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccucuucc ucgcccucau caucugcaac gccaucaucg acccccucau cuacgccuuc      900

cacucccagg agcuccgccg cacccucaag gagguccuca ccugcuccug guga            954


<210>  2726
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MC1_R__Homo_sapiens__AHC09597

<400>  2726
auggccgugc agggcagcca aagaaggcug cucggguccc uuaacucuac ccccacagcu       60

aucccucagc ugggauuggc agccaaucag acuggugcgc ggugcuuaga ggucucaauu      120

agugacggcc uguuccuaag ccucgggcug guuucccuug uggaaaacgc ucugguagug      180

gccacgauag caaagaaucg caacuugcac ucuccaaugu acuguuuuau cugcugucuc      240

gcccugucgg aucugcucgu cucaggaagc aauguguuag agaccgcugu uauucugcuu      300

uuggaagcag gcgcccuggu ggcucgagcc gcgguccuac agcaacucga caacgugauc      360

gauguaauua caugcaguuc caugcugucu agccuuuguu uccugggugc aaucgccguu      420

gaccguuaua uauccaucuu uuacgcuuug ugcuaucauu caauugugac ucucccgaga      480

gccaggcggg cagucgcugc caucugggug gcgagugugg ucuucagcac ccuguuuauu      540

gccuacuaug aucacguugc aguguuacug ugucucguag uguucuuucu ugcuaugcug      600

gucuugaugg ccgugcuaua cguucauaug cuggcucgcg ccugccagca cgcacagggg      660

aucgccagac uccauaaaag gcagcggccc gugcaccaag gauucggccu gaagggcgcu      720

gucacacuua ccauacuguu ggggaucuuu uuccucuguu ggggaccauu uuuccugcac      780

uuaacucuga uugugcuaug cccugagcau cccacaugug guugcauuuu uaaaaauuuc      840

aaccucuucc uggcgcuuau caucugcaau gcaauuauag acccuuugau cuaugccuuu      900

cacucucagg aacugcgccg aacccucaag gagguacuga cguguuccug guga            954


<210>  2727
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MC1_R__Homo_sapiens__AHC09597

<400>  2727
auggccgugc agggcagcca gagaagacug cugggcagcc ugaacagcac ccccaccgcc       60

aucccccagc ugggccuggc cgccaaccag accggcgcca gaugccugga ggugagcauc      120

agcgacggcc uguuccugag ccugggccug gugagccugg uggagaacgc ccugguggug      180

gccaccaucg ccaagaacag aaaccugcac agccccaugu acugcuucau cugcugccug      240

gcccugagcg accugcuggu gagcggcagc aacgugcugg agaccgccgu gauccugcug      300

cuggaggccg gcgcccuggu ggccagagcc gccgugcugc agcagcugga caacgugauc      360

gacgugauca ccugcagcag caugcugagc agccugugcu uccugggcgc caucgccgug      420

gacagauaca ucagcaucuu cuacgcccug ugcuaccaca gcaucgugac ccugcccaga      480

gccagaagag ccguggccgc caucugggug gccagcgugg uguucagcac ccuguucauc      540

gccuacuacg accacguggc cgugcugcug ugccuggugg uguucuuccu ggccaugcug      600

gugcugaugg ccgugcugua cgugcacaug cuggccagag ccugccagca cgcccagggc      660

aucgccagac ugcacaagag acagagaccc gugcaccagg gcuucggccu gaagggcgcc      720

gugacccuga ccauccugcu gggcaucuuc uuccugugcu ggggccccuu cuuccugcac      780

cugacccuga ucgugcugug ccccgagcac cccaccugcg gcugcaucuu caagaacuuc      840

aaccuguucc uggcccugau caucugcaac gccaucaucg acccccugau cuacgccuuc      900

cacagccagg agcugagaag aacccugaag gaggugcuga ccugcagcug guga            954


<210>  2728
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MC1_R__Homo_sapiens__AHC09597

<400>  2728
auggccgugc agggcagcca aagacggcug cucggguccc ugaacucuac ccccacagcu       60

aucccucagc uuggacuggc cgcgaaucag acgggcgcuc gcugccucga ggucagcauu      120

uccgacgggc uguuccuuuc ucugggacuc guuagccugg uggaaaacgc ccuggugguc      180

gccaccaucg cuaagaauag aaaccuccac uccccgaugu acuguuuuau uugcugucug      240

gcccuuucug aucugcucgu gagcggcucc aauguucugg agacagcugu gauccuucug      300

cucgaagccg gggcgcuggu cgcccgggcu gccgugcugc agcaacucga caacguuauu      360

gaugugauua ccugcagcuc uaugcugucc agccuuuguu uccugggagc uaucgccguc      420

gaccgcuaua ucucuaucuu uuacgcgcuc ugcuaucauu ccauugugac acugcccaga      480

gcccggcgcg cuguggccgc uaucuggguc gccagcguug uguucucuac ccuuuuuauu      540

gccuacuaug aucacguggc uguccugcuc ugucuggugg uuuucuuucu ggcgaugcuc      600

gugcugaugg ccguccuuua cgugcauaug cuggcuagag ccugccagca cgcccagggc      660

aucgcucggc uccauaaacg ccagagaccu guucaccaag gcuucgggcu gaagggagcc      720

gugacacuua ccauucugcu cggcaucuuu uuccuguguu gggggcccuu uuuccugcac      780

cucacgcuga ucguccuuug cccugagcau cccaccugug gaugcauuuu uaaaaauuuc      840

aaccuguucc ucgcgcugau cauuugcaau gcuaucauug acccucugau cuaugccuuu      900

cacucccagg aacuucggcg cacacucaag gaggugcuga ccuguagcug guga            954


<210>  2729
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  mesothelin__Homo_sapiens__Q13421

<400>  2729

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  2730
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  mesothelin__Homo_sapiens__EAW85719

<400>  2730
auggccuugc caacggcucg accccuguug ggguccugug ggacccccgc ccucggcagc       60

cuccuguucc ugcucuucag ccucggaugg gugcagcccu cgaggacccu ggcuggagag      120

acagggcagg aggcugcgcc ccuggacgga guccuggcca acccaccuaa cauuuccagc      180

cucuccccuc gccaacuccu uggcuucccg ugugcggagg uguccggccu gagcacggag      240

cguguccggg agcuggcugu ggccuuggca cagaagaaug ucaagcucuc aacagagcag      300

cugcgcuguc uggcucaccg gcucucugag ccccccgagg accuggacgc ccucccauug      360

gaccugcugc uauuccucaa cccagaugcg uucucggggc cccaggccug cacccguuuc      420

uucucccgca ucacgaaggc caauguggac cugcucccga ggggggcucc cgagcgacag      480

cggcugcugc cugcggcucu ggccugcugg ggugugcggg ggucucugcu gagcgaggcu      540

gaugugcggg cucugggagg ccuggcuugc gaccugccug ggcgcuuugu ggccgagucg      600

gccgaagugc ugcuaccccg gcuggugagc ugcccgggac cccuggacca ggaccagcag      660

gaggcagcca gggcggcucu gcagggcggg ggaccccccu acggcccccc gucgacaugg      720

ucugucucca cgauggacgc ucugcggggc cugcugcccg ugcugggcca gcccaucauc      780

cgcagcaucc cgcagggcau cguggccgcg uggcggcaac gcuccucucg ggacccaucc      840

uggcggcagc cugaacggac cauccuccgg ccgcgguucc ggcgggaagu ggagaagaca      900

gccuguccuu caggcaagaa ggcccgcgag auagacgaga gccucaucuu cuacaagaag      960

ugggagcugg aagccugcgu ggaugcggcc cugcuggcca cccagaugga ccgcgugaac     1020

gccauccccu ucaccuacga gcagcuggac guccuaaagc auaaacugga ugagcucuac     1080

ccacaagguu accccgaguc ugugauccag caccugggcu accucuuccu caagaugagc     1140

ccugaggaca uucgcaagug gaaugugacg ucccuggaga cccugaaggc uuugcuugaa     1200

gucaacaaag ggcacgaaau gaguccucag gcuccucggc ggccccuccc acagguggcc     1260

acccugaucg accgcuuugu gaagggaagg ggccagcuag acaaagacac ccuagacacc     1320

cugaccgccu ucuacccugg guaccugugc ucccucagcc ccgaggagcu gagcuccgug     1380

ccccccagca gcaucugggc ggucaggccc caggaccugg acacguguga cccaaggcag     1440

cuggacgucc ucuaucccaa ggcccgccuu gcuuuccaga acaugaacgg guccgaauac     1500

uucgugaaga uccaguccuu ccuggguggg gcccccacgg aggauuugaa ggcgcucagu     1560

cagcagaaug ugagcaugga cuuggccacg uucaugaagc ugcggacgga ugcggugcug     1620

ccguugacug uggcugaggu gcagaaacuu cugggacccc acguggaggg ccugaaggcg     1680

gaggagcggc accgcccggu gcgggacugg auccuacggc agcggcagga cgaccuggac     1740

acgcuggggc uggggcuaca gggcggcauc cccaacggcu accugguccu agaccucagc     1800

augcaagagg cccucucggg gacgcccugc cuccuaggac cuggaccugu ucucaccguc     1860

cuggcacugc uccuagccuc cacccuggcc uga                                  1893


<210>  2731
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       mesothelin__Homo_sapiens__EAW85719

<400>  2731
auggcccugc ccaccgcccg cccgcuccug ggcagcugcg ggacccccgc gcugggcucc       60

cuccuguucc uccuguucag ccuggggugg gugcagcccu cccggacgcu ggccggcgag      120

accgggcagg aggccgcgcc ccucgacggc guccuggcca acccgcccaa caucagcucc      180

cugagccccc gccagcuccu gggcuucccc ugcgccgagg uguccgggcu gagcaccgag      240

cgggugcgcg agcucgccgu cgcccuggcc cagaagaacg ugaagcuguc caccgagcag      300

cuccggugcc uggcgcaccg ccugagcgag ccgcccgagg accucgacgc ccugccccug      360

gaccuccugc uguuccucaa ccccgacgcc uucuccggcc cgcaggccug cacgcgguuc      420

uucagccgca ucaccaaggc caacguggac cugcugcccc gcggggcgcc cgagcggcag      480

cggcuccugc ccgccgcccu ggccugcugg ggcguccgcg ggucccuccu gagcgaggcc      540

gacgugcggg cgcugggcgg ccucgccugc gaccugccgg ggcgcuucgu ggccgagucc      600

gccgaggucc ugcucccccg gcuggugagc ugccccggcc cccuggacca ggaccagcag      660

gaggccgcgc gcgccgcccu ccagggcggg ggcccgcccu acgggccgcc cuccaccugg      720

agcgugucca ccauggacgc ccugcggggc cugcuccccg uccuggggca gcccaucauc      780

cgcagcaucc cccagggcau cguggccgcg uggcggcagc gcagcucccg ggaccccagc      840

uggcgccagc cggagcgcac gauccugcgg ccccgcuucc ggcgcgaggu ggagaagacc      900

gccugccccu ccgggaagaa ggcccgggag aucgacgaga gccucaucuu cuacaagaag      960

ugggagcugg aggccugcgu cgacgcggcc cugcuggcca cccagaugga ccgcgugaac     1020

gccaucccgu ucaccuacga gcagcucgac gugcugaagc acaagcugga cgagcucuac     1080

ccccagggcu accccgaguc cgucauccag caccugggcu accuguuccu caagaugagc     1140

cccgaggaca uccggaagug gaacgugacg ucccuggaga cccugaaggc ccuccuggag     1200

gugaacaagg ggcacgagau gagcccgcag gcgccccgcc ggccccugcc ccaggucgcc     1260

acccucaucg accgcuucgu gaagggccgg gggcagcugg acaaggacac ccuggacacg     1320

cucaccgccu ucuacccggg cuaccugugc ucccugagcc ccgaggagcu cuccagcgug     1380

ccgcccucca gcaucugggc cguccgcccc caggaccugg acacgugcga cccccggcag     1440

cuggacgugc ucuaccccaa ggcccgccug gcguuccaga acaugaacgg guccgaguac     1500

uucgucaaga uccagagcuu ccugggcggc gcccccaccg aggaccucaa ggcccugucc     1560

cagcagaacg ugagcaugga ccuggccacc uucaugaagc uccggaccga cgccgugcug     1620

ccgcugaccg ucgcggaggu gcagaagcuc cuggggcccc acguggaggg ccugaaggcc     1680

gaggagcgcc accggcccgu ccgcgacugg auccuccggc agcgccagga cgaccuggac     1740

acccuggggc ucggccugca gggcgggauc cccaacggcu accuggugcu cgaccugucc     1800

augcaggagg cccugagcgg gacgccgugc cuccugggcc ccgggcccgu gcugaccguc     1860

cucgcccugc ugcucgcgag cacccuggcc uga                                  1893


<210>  2732
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       mesothelin__Homo_sapiens__EAW85719

<400>  2732
auggcccucc ccaccgcccg cccccuccuc ggcuccugcg gcacccccgc ccucggcucc       60

cuccucuucc uccucuucuc ccucggcugg guccagcccu cccgcacccu cgccggcgag      120

accggccagg aggccgcccc ccucgacggc guccucgcca acccccccaa caucuccucc      180

cucucccccc gccagcuccu cggcuucccc ugcgccgagg ucuccggccu cuccaccgag      240

cgcguccgcg agcucgccgu cgcccucgcc cagaagaacg ucaagcucuc caccgagcag      300

cuccgcugcc ucgcccaccg ccucuccgag ccccccgagg accucgacgc ccucccccuc      360

gaccuccucc ucuuccucaa ccccgacgcc uucuccggcc cccaggccug cacccgcuuc      420

uucucccgca ucaccaaggc caacgucgac cuccuccccc gcggcgcccc cgagcgccag      480

cgccuccucc ccgccgcccu cgccugcugg ggcguccgcg gcucccuccu cuccgaggcc      540

gacguccgcg cccucggcgg ccucgccugc gaccuccccg gccgcuucgu cgccgagucc      600

gccgaggucc uccucccccg ccucgucucc ugccccggcc cccucgacca ggaccagcag      660

gaggccgccc gcgccgcccu ccagggcggc ggcccccccu acggcccccc cuccaccugg      720

uccgucucca ccauggacgc ccuccgcggc cuccuccccg uccucggcca gcccaucauc      780

cgcuccaucc cccagggcau cgucgccgcc uggcgccagc gcuccucccg cgaccccucc      840

uggcgccagc ccgagcgcac cauccuccgc ccccgcuucc gccgcgaggu cgagaagacc      900

gccugccccu ccggcaagaa ggcccgcgag aucgacgagu cccucaucuu cuacaagaag      960

ugggagcucg aggccugcgu cgacgccgcc cuccucgcca cccagaugga ccgcgucaac     1020

gccauccccu ucaccuacga gcagcucgac guccucaagc acaagcucga cgagcucuac     1080

ccccagggcu accccgaguc cgucauccag caccucggcu accucuuccu caagaugucc     1140

cccgaggaca uccgcaagug gaacgucacc ucccucgaga cccucaaggc ccuccucgag     1200

gucaacaagg gccacgagau guccccccag gccccccgcc gcccccuccc ccaggucgcc     1260

acccucaucg accgcuucgu caagggccgc ggccagcucg acaaggacac ccucgacacc     1320

cucaccgccu ucuaccccgg cuaccucugc ucccucuccc ccgaggagcu cuccuccguc     1380

ccccccuccu ccaucugggc cguccgcccc caggaccucg acaccugcga cccccgccag     1440

cucgacgucc ucuaccccaa ggcccgccuc gccuuccaga acaugaacgg cuccgaguac     1500

uucgucaaga uccaguccuu ccucggcggc gcccccaccg aggaccucaa ggcccucucc     1560

cagcagaacg ucuccaugga ccucgccacc uucaugaagc uccgcaccga cgccguccuc     1620

ccccucaccg ucgccgaggu ccagaagcuc cucggccccc acgucgaggg ccucaaggcc     1680

gaggagcgcc accgccccgu ccgcgacugg auccuccgcc agcgccagga cgaccucgac     1740

acccucggcc ucggccucca gggcggcauc cccaacggcu accucguccu cgaccucucc     1800

augcaggagg cccucuccgg cacccccugc cuccucggcc ccggccccgu ccucaccguc     1860

cucgcccucc uccucgccuc cacccucgcc uga                                  1893


<210>  2733
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       mesothelin__Homo_sapiens__EAW85719

<400>  2733
auggcccugc ccaccgcuag accucuccuu ggcagcugcg ggacaccagc acugggaucc       60

uuguuauucc ugcuauuuuc ucucgguugg gugcagccgu caaggacucu ggccggcgag      120

acggggcaag aagcggcucc ccuugacgga guccuggcca acccuccaaa uaucaguagc      180

uugucucccc ggcagcuccu gggcuucccu ugugcagagg uuuccggucu gucgaccgaa      240

cgcgugcgag agcucgccgu agcuuuagca cagaagaacg ugaaacuguc aacagaacag      300

cuucguugcu uggcccacag acugagcgag ccacccgagg aucuagacgc ucucccucug      360

gaucuucugu uguuucucaa uccagacgcc uucagugggc cgcaagcgug uacuagguuu      420

uucucccgga uuaccaaggc aaacgucgau cuguuacccc gcggagcccc ugaaagacag      480

aggcugcucc cagcugcccu ugcaugcugg ggcgugcggg gcucucuguu gagcgaggcu      540

gacguucgcg cccuaggggg acuggcgugu gaucuccccg gucgauuugu ggccgaaucc      600

gcagaggucc ugcuuccuag acugguguca ugcccaggcc ccuuggacca ggaucagcaa      660

gaggcugcca gggcugcccu ccaaggggga ggcccgccuu acgguccccc aaguacaugg      720

agcguaucua ccauggacgc acugcggggg uuacugccug uucuaggaca gcccauaauc      780

cguuccauuc cacagggcau cguggccgcu uggcgccaga gaucaagcag ggaucccagu      840

uggcggcagc cugaacgaac uauucuccgc ccaagauuca ggcgggaggu cgaaaagaca      900

gcguguccgu cuggcaagaa agcacgcgag aucgacgaau cccugauauu uuauaagaag      960

ugggagcuug aggccugcgu ggaugcugcc uugcuggcaa cccagaugga cagagugaau     1020

gccauccccu ucacguacga acaacucgac guccugaaac auaaacuuga ugagcuguau     1080

ccucaggggu acccagaaag cguuauucag cacuugggau aucucuuucu gaaaaugucg     1140

cccgaggaca ucaggaagug gaacgugacu ucuuuagaaa cccugaaagc ucuacucgag     1200

guaaauaagg gucaugagau guccccucag gccccacguc ggccccugcc gcaaguggca     1260

acacuuauug aucgauucgu caagggcaga gggcaguugg acaaagauac ucuggacacc     1320

cucacagcgu uuuacccugg auaucugugu ucauuaaguc cagaggaacu gagcuccgug     1380

cccccuucua gcaucugggc uguuaggccc caggaucuug auaccugcga cccacgccag     1440

uuggacgugc ucuacccuaa ggcccggcug gcauuccaaa acaugaaugg cucagaauac     1500

uucgucaaaa uacagaguuu ucuagguggg gcccccacgg aggaucugaa ggcucucucc     1560

cagcagaacg ugagcaugga ccuggccacu uucaugaaac uuagaacaga cgcaguauug     1620

ccacugaccg uugcugaagu gcaaaaguua cucggcccgc acgucgaggg acugaaagcc     1680

gaggaaaggc aucgcccugu gcgagauugg auucuucggc agcgucagga cgaucuggac     1740

acuuugggcc ucgggcugca gggagguauc cccaauggcu aucuaguccu ggaucucucu     1800

augcaagagg cgcugucagg gacaccaugu cuuuugggac ccggcccugu gcugaccguu     1860

uuagcccucc ugcuugcuag uacgcuggca uga                                  1893


<210>  2734
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       mesothelin__Homo_sapiens__EAW85719

<400>  2734
auggcccugc ccaccgccag accccugcug ggcagcugcg gcacccccgc ccugggcagc       60

cugcuguucc ugcuguucag ccugggcugg gugcagccca gcagaacccu ggccggcgag      120

accggccagg aggccgcccc ccuggacggc gugcuggcca acccccccaa caucagcagc      180

cugagcccca gacagcugcu gggcuucccc ugcgccgagg ugagcggccu gagcaccgag      240

agagugagag agcuggccgu ggcccuggcc cagaagaacg ugaagcugag caccgagcag      300

cugagaugcc uggcccacag acugagcgag ccccccgagg accuggacgc ccugccccug      360

gaccugcugc uguuccugaa ccccgacgcc uucagcggcc cccaggccug caccagauuc      420

uucagcagaa ucaccaaggc caacguggac cugcugccca gaggcgcccc cgagagacag      480

agacugcugc ccgccgcccu ggccugcugg ggcgugagag gcagccugcu gagcgaggcc      540

gacgugagag cccugggcgg ccuggccugc gaccugcccg gcagauucgu ggccgagagc      600

gccgaggugc ugcugcccag acuggugagc ugccccggcc cccuggacca ggaccagcag      660

gaggccgcca gagccgcccu gcagggcggc ggcccccccu acggcccccc cagcaccugg      720

agcgugagca ccauggacgc ccugagaggc cugcugcccg ugcugggcca gcccaucauc      780

agaagcaucc cccagggcau cguggccgcc uggagacaga gaagcagcag agaccccagc      840

uggagacagc ccgagagaac cauccugaga cccagauuca gaagagaggu ggagaagacc      900

gccugcccca gcggcaagaa ggccagagag aucgacgaga gccugaucuu cuacaagaag      960

ugggagcugg aggccugcgu ggacgccgcc cugcuggcca cccagaugga cagagugaac     1020

gccauccccu ucaccuacga gcagcuggac gugcugaagc acaagcugga cgagcuguac     1080

ccccagggcu accccgagag cgugauccag caccugggcu accuguuccu gaagaugagc     1140

cccgaggaca ucagaaagug gaacgugacc agccuggaga cccugaaggc ccugcuggag     1200

gugaacaagg gccacgagau gagcccccag gcccccagaa gaccccugcc ccagguggcc     1260

acccugaucg acagauucgu gaagggcaga ggccagcugg acaaggacac ccuggacacc     1320

cugaccgccu ucuaccccgg cuaccugugc agccugagcc ccgaggagcu gagcagcgug     1380

ccccccagca gcaucugggc cgugagaccc caggaccugg acaccugcga ccccagacag     1440

cuggacgugc uguaccccaa ggccagacug gccuuccaga acaugaacgg cagcgaguac     1500

uucgugaaga uccagagcuu ccugggcggc gcccccaccg aggaccugaa ggcccugagc     1560

cagcagaacg ugagcaugga ccuggccacc uucaugaagc ugagaaccga cgccgugcug     1620

ccccugaccg uggccgaggu gcagaagcug cugggccccc acguggaggg ccugaaggcc     1680

gaggagagac acagacccgu gagagacugg auccugagac agagacagga cgaccuggac     1740

acccugggcc ugggccugca gggcggcauc cccaacggcu accuggugcu ggaccugagc     1800

augcaggagg cccugagcgg cacccccugc cugcugggcc ccggccccgu gcugaccgug     1860

cuggcccugc ugcuggccag cacccuggcc uga                                  1893


<210>  2735
<211>  1893
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       mesothelin__Homo_sapiens__EAW85719

<400>  2735
auggcccugc ccaccgcuag accucuccug ggcagcugcg ggacaccggc ccuuggaucc       60

cuucucuucc ugcuguuuuc ucugggcugg gugcagccca gccggacgcu cgcgggggag      120

accggacaag aagcugcccc ucuggacggc guccuggcca aucccccuaa caucuccucu      180

cucagccccc gccagcugcu uggguucccu ugugcugagg uuuccggacu gucuacagaa      240

agagugcggg agcucgccgu ggcucuggcc cagaagaacg ucaaacuuag caccgaacag      300

cugcgcugcc ucgcgcacag acuguccgag ccgcccgagg aucuggacgc ccucccucug      360

gaucuucugc ucuuucugaa ucccgacgcu uucagcggcc cucaagccug uacacgguuu      420

uucucucgca uuaccaaggc uaacguggau cuucugccca gaggcgcccc ggaacggcag      480

cgccuccugc cugcggcccu ggcuugcugg ggcguuagag gaucccuccu gagcgaggcc      540

gacgugcggg cucuuggcgg gcuggccugu gaucuccccg gacgcuuugu cgccgaaucu      600

gcugaggugc ugcuuccuag acugguuucc ugccccggcc cccucgacca ggaucagcaa      660

gaggcggccc gggcugcccu gcaaggggga ggcccuccgu acgggccccc uagcacaugg      720

ucugugucca ccauggacgc ccugcgcggg cuccugcccg uccuuggaca gccuaucauu      780

agaagcaucc cccagggcau uguggcugcc uggcggcaga gauccucucg cgauccgagc      840

uggcggcagc cugaaagaac gauccugcgc ccccgguuca gacgcgaggu ggagaaaacc      900

gcguguccuu ccgggaagaa agcucgggag aucgacgaaa gccucaucuu uuauaagaag      960

ugggagcugg aggccugcgu cgaugccgcu cugcuugcca cacagaugga cagaguuaau     1020

gcuauucccu ucaccuacga acaacucgac gugcugaaac auaagcugga ugagcucuau     1080

ccucagggau accccgaauc ugugauucag caccugggcu aucuuuuucu gaaaaugucc     1140

ccggaggaca uccgcaagug gaacgucaca agccucgaaa cccugaaagc ccugcuugag     1200

gugaauaagg ggcaugagau gucuccucag gcgccccgga gaccccuccc ucaaguugcc     1260

acgcugauug aucgcuucgu gaagggacgg ggccagcugg acaaagauac acucgacacc     1320

cugacagcuu uuuacccggg cuaucuuugu agccuguccc ccgaagaacu cucuagcguc     1380

ccucccucca gcaucugggc cgugagaccu caggaucugg auaccugcga cccccggcag     1440

cuggacguuc uuuacccuaa ggcucgccuc gccuuccaaa acaugaaugg gucugaauac     1500

uucgugaaaa uucaguccuu ucugggaggc gcgcccaccg aggaucugaa ggcccucagc     1560

cagcagaacg ucucuaugga ccuggcuaca uucaugaaac uuagaacgga cgccgugcug     1620

ccgcucaccg ucgcugaagu gcaaaagcug cuggggccuc acguugaggg acuuaaagcc     1680

gaggaacggc auagacccgu gcgcgauugg auccuccggc agagacagga cgaucuggac     1740

acacugggcc ucgggcugca gggcggaauc ccuaauggcu aucuuguccu ggaucucucc     1800

augcaagagg cccugagcgg gacccccugu cugcuuggac cgggcccugu gcugacaguu     1860

cucgcucugc uccuggcguc cacccuugcc uga                                  1893


<210>  2736
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__O75030-8

<400>  2736

Met Glu Ala Leu Arg Val Gln Met Phe Met Pro Cys Ser Phe Glu Ser 
1               5                   10                  15      


Leu Tyr Leu Ser Ser Ala Glu His Pro Gly Ala Ser Lys Pro Pro Ile 
            20                  25                  30          


Ser Ser Ser Ser Met Thr Ser Arg Ile Leu Leu Arg Gln Gln Leu Met 
        35                  40                  45              


Arg Glu Gln Met Gln Glu Gln Glu Arg Arg Glu Gln Gln Gln Lys Leu 
    50                  55                  60                  


Gln Ala Ala Gln Phe Met Gln Gln Arg Val Pro Val Ser Gln Thr Pro 
65                  70                  75                  80  


Ala Ile Asn Val Ser Val Pro Thr Thr Leu Pro Ser Ala Thr Gln Val 
                85                  90                  95      


Pro Met Glu Val Leu Lys Val Gln Thr His Leu Glu Asn Pro Thr Lys 
            100                 105                 110         


Tyr His Ile Gln Gln Ala Gln Arg Gln Gln Val Lys Gln Tyr Leu Ser 
        115                 120                 125             


Thr Thr Leu Ala Asn Lys His Ala Asn Gln Val Leu Ser Leu Pro Cys 
    130                 135                 140                 


Pro Asn Gln Pro Gly Asp His Val Met Pro Pro Val Pro Gly Ser Ser 
145                 150                 155                 160 


Ala Pro Asn Ser Pro Met Ala Met Leu Thr Leu Asn Ser Asn Cys Glu 
                165                 170                 175     


Lys Glu Gly Phe Tyr Lys Phe Glu Glu Gln Asn Arg Ala Glu Ser Glu 
            180                 185                 190         


Cys Pro Gly Met Asn Thr His Ser Arg Ala Ser Cys Met Gln Met Asp 
        195                 200                 205             


Asp Val Ile Asp Asp Ile Ile Ser Leu Glu Ser Ser Tyr Asn Glu Glu 
    210                 215                 220                 


Ile Leu Gly Leu Met Asp Pro Ala Leu Gln Met Ala Asn Thr Leu Pro 
225                 230                 235                 240 


Val Ser Gly Asn Leu Ile Asp Leu Tyr Gly Asn Gln Gly Leu Pro Pro 
                245                 250                 255     


Pro Gly Leu Thr Ile Ser Asn Ser Cys Pro Ala Asn Leu Pro Asn Ile 
            260                 265                 270         


Lys Arg Glu Leu Thr Glu Ser Glu Ala Arg Ala Leu Ala Lys Glu Arg 
        275                 280                 285             


Gln Lys Lys Asp Asn His Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn 
    290                 295                 300                 


Ile Asn Asp Arg Ile Lys Glu Leu Gly Thr Leu Ile Pro Lys Ser Asn 
305                 310                 315                 320 


Asp Pro Asp Met Arg Trp Asn Lys Gly Thr Ile Leu Lys Ala Ser Val 
                325                 330                 335     


Asp Tyr Ile Arg Lys Leu Gln Arg Glu Gln Gln Arg Ala Lys Glu Leu 
            340                 345                 350         


Glu Asn Arg Gln Lys Lys Leu Glu His Ala Asn Arg His Leu Leu Leu 
        355                 360                 365             


Arg Ile Gln Glu Leu Glu Met Gln Ala Arg Ala His Gly Leu Ser Leu 
    370                 375                 380                 


Ile Pro Ser Thr Gly Leu Cys Ser Pro Asp Leu Val Asn Arg Ile Ile 
385                 390                 395                 400 


Lys Gln Glu Pro Val Leu Glu Asn Cys Ser Gln Asp Leu Leu Gln His 
                405                 410                 415     


His Ala Asp Leu Thr Cys Thr Thr Thr Leu Asp Leu Thr Asp Gly Thr 
            420                 425                 430         


Ile Thr Phe Asn Asn Asn Leu Gly Thr Gly Thr Glu Ala Asn Gln Ala 
        435                 440                 445             


Tyr Ser Val Pro Thr Lys Met Gly Ser Lys Leu Glu Asp Ile Leu Met 
    450                 455                 460                 


Asp Asp Thr Leu Ser Pro Val Gly Val Thr Asp Pro Leu Leu Ser Ser 
465                 470                 475                 480 


Val Ser Pro Gly Ala Ser Lys Thr Ser Ser Arg Arg Ser Ser Met Ser 
                485                 490                 495     


Met Glu Glu Thr Glu His Thr Cys 
            500                 


<210>  2737
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__CCDS46865.1

<400>  2737
auggaggcgc uuagaguuca gauguucaug ccaugcuccu uugaaagcuu guaucucagu       60

uccgccgagc auccuggggc cuccaagccu ccgauaagcu ccuccaguau gacaucacgc      120

aucuugcuac gccagcaacu caugcgugag cagaugcagg agcaggagcg cagggagcag      180

cagcagaagc ugcaggcggc ccaguucaug caacagagag ugcccgugag ucagacacca      240

gccauaaacg ucagugugcc caccacccuu cccucugcca cgcaggugcc gauggaaguc      300

cuuaaggugc agacccaccu cgaaaacccc accaaguacc acauacagca agcccaacgg      360

cagcagguaa agcaguaccu uucuaccacu uuagcaaaua aacaugccaa ccaaguccug      420

agcuugccau guccaaacca gccuggcgau caugucaugc caccggugcc ggggagcagc      480

gcacccaaca gccccauggc uaugcuuacg cuuaacucca acugugaaaa agagggauuu      540

uauaaguuug aagagcaaaa cagggcagag agcgagugcc caggcaugaa cacacauuca      600

cgagcguccu guaugcagau ggaugaugua aucgaugaca ucauuagccu agaaucaagu      660

uauaaugagg aaaucuuggg cuugauggau ccugcuuugc aaauggcaaa uacguugccu      720

gucucgggaa acuugauuga ucuuuaugga aaccaagguc ugcccccacc aggccucacc      780

aucagcaacu ccuguccagc caaccuuccc aacauaaaaa gggagcucac agagucugaa      840

gcaagagcac uggccaaaga gaggcagaaa aaggacaauc acaaccugau ugaacgaaga      900

agaagauuua acauaaauga ccgcauuaaa gaacuaggua cuuugauucc caagucaaau      960

gauccagaca ugcgcuggaa caagggaacc aucuuaaaag cauccgugga cuauauccga     1020

aaguugcaac gagaacagca acgcgcaaaa gaacuugaaa accgacagaa gaaacuggag     1080

cacgccaacc ggcauuuguu gcucagaaua caggaacuug aaaugcaggc ucgagcucau     1140

ggacuuuccc uuauuccauc cacgggucuc ugcucuccag auuuggugaa ucggaucauc     1200

aagcaagaac ccguucuuga gaacugcagc caagaccucc uucagcauca ugcagaccua     1260

accuguacaa caacucucga ucucacggau ggcaccauca ccuucaacaa caaccucgga     1320

acugggacug aggccaacca agccuauagu guccccacaa aaaugggauc caaacuggaa     1380

gacauccuga uggacgacac ccuuucuccc gucgguguca cugauccacu ccuuuccuca     1440

gugucccccg gagcuuccaa aacaagcagc cggaggagca guaugagcau ggaagagacg     1500

gagcacacuu guuag                                                      1515


<210>  2738
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MITF__Homo_sapiens__CCDS46865.1

<400>  2738
auggaggccc ugcgcgugca gauguucaug cccugcagcu ucgagucccu cuaccugagc       60

uccgccgagc acccgggcgc gagcaagccg cccaucucca gcuccagcau gaccucccgg      120

auccugcucc gccagcagcu gaugcgggag cagaugcagg agcaggagcg ccgggagcag      180

cagcagaagc ugcaggccgc ccaguucaug cagcagcgcg uccccgugag ccagaccccc      240

gccaucaacg uguccguccc caccacccuc cccagcgcca cccaggugcc cauggaggug      300

cugaaggucc agacccaccu ggagaacccg acgaaguacc acauccagca ggcgcagcgg      360

cagcagguca agcaguaccu cuccaccacc cuggccaaca agcacgccaa ccaggugcug      420

agccuccccu gccccaacca gcccggggac cacgugaugc cgcccgugcc cggcuccagc      480

gcccccaacu ccccgauggc gaugcugacc cugaacagca acugcgagaa ggagggguuc      540

uacaaguucg aggagcagaa ccgcgccgag uccgagugcc ccggcaugaa cacgcacagc      600

cgggccagcu gcaugcagau ggacgacgug aucgacgaca ucaucucccu cgagagcucc      660

uacaacgagg agauccuggg gcugauggac cccgcccucc agauggccaa cacccugccc      720

gucagcggca accugaucga ccucuacggc aaccaggggc ugccgccgcc cggccugacc      780

aucuccaaca gcugccccgc gaaccucccc aacaucaagc gcgagcugac cgaguccgag      840

gcccgggccc uggccaagga gcgccagaag aaggacaacc acaaccucau cgagcggcgc      900

cggcgcuuca acaucaacga ccggaucaag gagcugggga cgcugauccc caagagcaac      960

gaccccgaca ugcgcuggaa caagggcacc auccucaagg ccuccgugga cuacauccgg     1020

aagcugcagc gcgagcagca gcgggcgaag gagcuggaga accgccagaa gaagcucgag     1080

cacgccaacc gccaccuccu gcuccggauc caggagcugg agaugcaggc ccgcgcccac     1140

gggcugagcc ucauccccuc caccggccug ugcagcccgg accuggugaa ccggaucauc     1200

aagcaggagc ccguccucga gaacugcucc caggaccugc ugcagcacca cgccgaccug     1260

accugcacga ccacccugga ccugaccgac ggcacgauca ccuucaacaa caaccucggg     1320

accggcaccg aggcgaacca ggccuacagc gugcccacga agaugggguc caagcuggag     1380

gacauccuga uggacgacac ccugagcccg gugggcguca ccgacccccu ccuguccagc     1440

gugucccccg gcgccagcaa gaccagcucc cgccggagcu ccaugagcau ggaggagacg     1500

gagcacacgu gcuga                                                      1515


<210>  2739
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MITF__Homo_sapiens__CCDS46865.1

<400>  2739
auggaggccc uccgcgucca gauguucaug cccugcuccu ucgagucccu cuaccucucc       60

uccgccgagc accccggcgc cuccaagccc cccaucuccu ccuccuccau gaccucccgc      120

auccuccucc gccagcagcu caugcgcgag cagaugcagg agcaggagcg ccgcgagcag      180

cagcagaagc uccaggccgc ccaguucaug cagcagcgcg uccccgucuc ccagaccccc      240

gccaucaacg ucuccguccc caccacccuc cccuccgcca cccagguccc cauggagguc      300

cucaaggucc agacccaccu cgagaacccc accaaguacc acauccagca ggcccagcgc      360

cagcagguca agcaguaccu cuccaccacc cucgccaaca agcacgccaa ccagguccuc      420

ucccuccccu gccccaacca gcccggcgac cacgucaugc cccccguccc cggcuccucc      480

gcccccaacu cccccauggc caugcucacc cucaacucca acugcgagaa ggagggcuuc      540

uacaaguucg aggagcagaa ccgcgccgag uccgagugcc ccggcaugaa cacccacucc      600

cgcgccuccu gcaugcagau ggacgacguc aucgacgaca ucaucucccu cgaguccucc      660

uacaacgagg agauccucgg ccucauggac cccgcccucc agauggccaa cacccucccc      720

gucuccggca accucaucga ccucuacggc aaccagggcc uccccccccc cggccucacc      780

aucuccaacu ccugccccgc caaccucccc aacaucaagc gcgagcucac cgaguccgag      840

gcccgcgccc ucgccaagga gcgccagaag aaggacaacc acaaccucau cgagcgccgc      900

cgccgcuuca acaucaacga ccgcaucaag gagcucggca cccucauccc caaguccaac      960

gaccccgaca ugcgcuggaa caagggcacc auccucaagg ccuccgucga cuacauccgc     1020

aagcuccagc gcgagcagca gcgcgccaag gagcucgaga accgccagaa gaagcucgag     1080

cacgccaacc gccaccuccu ccuccgcauc caggagcucg agaugcaggc ccgcgcccac     1140

ggccucuccc ucauccccuc caccggccuc ugcucccccg accucgucaa ccgcaucauc     1200

aagcaggagc ccguccucga gaacugcucc caggaccucc uccagcacca cgccgaccuc     1260

accugcacca ccacccucga ccucaccgac ggcaccauca ccuucaacaa caaccucggc     1320

accggcaccg aggccaacca ggccuacucc guccccacca agaugggcuc caagcucgag     1380

gacauccuca uggacgacac ccucuccccc gucggcguca ccgacccccu ccucuccucc     1440

gucucccccg gcgccuccaa gaccuccucc cgccgcuccu ccauguccau ggaggagacc     1500

gagcacaccu gcuga                                                      1515


<210>  2740
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MITF__Homo_sapiens__CCDS46865.1

<400>  2740
auggaggccc ugagagugca gauguucaug cccugcagcu uugaaucccu cuaccuuucu       60

ucagcugagc acccuggcgc aaguaagcca ccgaucagcu ccucuucgau gaccucaagg      120

auucuguugc ggcaacaguu aaugcgcgaa cagaugcagg agcaagaacg acgugagcag      180

cagcagaaac ugcaagccgc gcaguucaug cagcagagag uccccguuag ccaaacuccu      240

gcuauaaacg ugaguguacc aacaacgcua cccuccgcca cccaggugcc uauggagguc      300

cucaaggugc agacacaucu ggaaaaucca acuaaauauc acauccaaca ggcacagagg      360

cagcaaguua agcaguaccu uucuaccaca cuggccaaca aacaugcuaa ucagguguug      420

agccuccccu guccuaacca gccaggggac cacgucaugc cgcccgugcc uggauccuca      480

gcaccaaaua gucccauggc caugcugacc cugaacagca auugcgagaa ggaagguuuu      540

uauaaguucg aggagcaaaa ccgggcugaa ucugaguguc cuggcaugaa uacucauucc      600

cgcgccucau gcaugcagau ggaugacgua auugaugaca ucauuagccu cgaaaguucu      660

uacaacgagg aaaucuuagg gcugauggau ccagcgcuuc agauggcaaa uacauugccc      720

guuuccggaa accugauaga ccuauauggc aaucaggguc ucccgccucc cgggcugacc      780

aucagcaacu cguguccagc caaucuuccu aacauuaaaa gagagcugac ggagucugaa      840

gcuagggccu uggcaaagga gcggcagaaa aaggauaacc acaaucucau cgaacgccga      900

agaagguuua acauuaauga ccggaucaaa gagcugggaa cuuuaauacc caaguccaac      960

gauccagaca ugcguuggaa uaagggcacc auucugaagg cuucagugga uuacauccgc     1020

aagcuccaaa gagaacagca gagggccaaa gagcuugaga accggcaaaa gaaacuggaa     1080

cacgcgaauc gacauuugcu acugcgcauu caggagcucg aaaugcaggc cagagcacac     1140

ggccugaguc uuauccccag cacagggcug ugcuccccug acuuggucaa caggaucauu     1200

aagcaagagc cagugcucga aaauuguucu caggaucugu uacagcauca cgcugaccug     1260

acuugcacca caacccuaga ccucacggau ggaacuauaa cauucaacaa uaaccugggu     1320

accggcacug aggccaauca ggcuuauagc gugccgacaa aaaugggguc aaaacuugag     1380

gacaucuuga uggaugacac ccugaguccc gucggaguua cggauccucu ccuguccagc     1440

gugucuccag gcgccucaaa gaccaguagc cggcgcuccu cuaugucgau ggaagagaca     1500

gaacacacuu guuga                                                      1515


<210>  2741
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MITF__Homo_sapiens__CCDS46865.1

<400>  2741
auggaggccc ugagagugca gauguucaug cccugcagcu ucgagagccu guaccugagc       60

agcgccgagc accccggcgc cagcaagccc cccaucagca gcagcagcau gaccagcaga      120

auccugcuga gacagcagcu gaugagagag cagaugcagg agcaggagag aagagagcag      180

cagcagaagc ugcaggccgc ccaguucaug cagcagagag ugcccgugag ccagaccccc      240

gccaucaacg ugagcgugcc caccacccug cccagcgcca cccaggugcc cauggaggug      300

cugaaggugc agacccaccu ggagaacccc accaaguacc acauccagca ggcccagaga      360

cagcagguga agcaguaccu gagcaccacc cuggccaaca agcacgccaa ccaggugcug      420

agccugcccu gccccaacca gcccggcgac cacgugaugc cccccgugcc cggcagcagc      480

gcccccaaca gccccauggc caugcugacc cugaacagca acugcgagaa ggagggcuuc      540

uacaaguucg aggagcagaa cagagccgag agcgagugcc ccggcaugaa cacccacagc      600

agagccagcu gcaugcagau ggacgacgug aucgacgaca ucaucagccu ggagagcagc      660

uacaacgagg agauccuggg ccugauggac cccgcccugc agauggccaa cacccugccc      720

gugagcggca accugaucga ccuguacggc aaccagggcc ugcccccccc cggccugacc      780

aucagcaaca gcugccccgc caaccugccc aacaucaaga gagagcugac cgagagcgag      840

gccagagccc uggccaagga gagacagaag aaggacaacc acaaccugau cgagagaaga      900

agaagauuca acaucaacga cagaaucaag gagcugggca cccugauccc caagagcaac      960

gaccccgaca ugagauggaa caagggcacc auccugaagg ccagcgugga cuacaucaga     1020

aagcugcaga gagagcagca gagagccaag gagcuggaga acagacagaa gaagcuggag     1080

cacgccaaca gacaccugcu gcugagaauc caggagcugg agaugcaggc cagagcccac     1140

ggccugagcc ugauccccag caccggccug ugcagccccg accuggugaa cagaaucauc     1200

aagcaggagc ccgugcugga gaacugcagc caggaccugc ugcagcacca cgccgaccug     1260

accugcacca ccacccugga ccugaccgac ggcaccauca ccuucaacaa caaccugggc     1320

accggcaccg aggccaacca ggccuacagc gugcccacca agaugggcag caagcuggag     1380

gacauccuga uggacgacac ccugagcccc gugggcguga ccgacccccu gcugagcagc     1440

gugagccccg gcgccagcaa gaccagcagc agaagaagca gcaugagcau ggaggagacc     1500

gagcacaccu gcuga                                                      1515


<210>  2742
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MITF__Homo_sapiens__CCDS46865.1

<400>  2742
auggaggccc ugagagugca gauguucaug cccugcagcu uugaaucccu cuaccugucu       60

agcgcugagc acccuggcgc cuccaagccg cccaucucua gcuccucuau gaccagccgg      120

auucuucugc gccaacagcu caugagagaa cagaugcagg agcaagaacg gcgcgagcag      180

cagcagaaac ugcaagcggc ucaguucaug cagcagagag ucccuguuuc ccaaacaccc      240

gccaucaacg ugagcgugcc uacgacccuu cccucugcca cacagguccc uauggaggug      300

cugaagguuc agacccaucu cgaaaauccg acaaaauauc acauucaaca ggcucagcgg      360

cagcaaguga agcaguaccu guccaccaca cuggccaaca aacaugcuaa ucagguccuc      420

agccugcccu guccuaacca gcccggggac cacgugaugc cucccguucc gggaucuucc      480

gccccuaaua gccccauggc gaugcuuacc cugaacucua auugcgagaa ggaaggcuuu      540

uauaaguucg aggagcaaaa ccgcgccgaa uccgaguguc cugggaugaa uacgcauagc      600

agagcuuccu gcaugcagau ggaugacgug aucgaugaca uuaucucucu cgaaagcucc      660

uacaacgagg aaauccuggg acuuauggau cccgcccugc agauggcuaa uacccucccc      720

gucagcggca accugauuga ccuguauggg aaucagggac ucccuccgcc cggccugaca      780

aucucuaacu ccuguccugc caaucuuccc aacauuaaac gggagcugac cgagagcgaa      840

gcgcgcgccc ucgcuaagga gagacagaaa aaggauaacc acaaucugau cgaacggcgc      900

agacgguuua acauuaauga ccgcaucaaa gagcuuggca cacugauucc uaagucuaac      960

gaucccgaca ugagauggaa uaaggggacc auccucaaag ccagcgugga uuacauccgg     1020

aagcugcaaa gagaacagca gcgcgcuaaa gagcuggaga accggcaaaa gaaacucgaa     1080

cacgccaaua gacaucugcu ucugcgcauu caggagcucg aaaugcaggc ccgggcucac     1140

ggacuguccc uuaucccguc uacgggccug ugcagcccug accucgugaa cagaauuauc     1200

aagcaagagc ccguccugga aaauuguucc caggaucugc uccagcauca cgcggaccug     1260

acaugcacca caacccuuga ccugaccgau gggacaauua cguucaacaa uaaccucgga     1320

accggcacag aggccaauca ggcuuauagc guuccuacca aaaugggguc uaagcuggag     1380

gacauccuga uggaugacac acuuuccccc gugggaguga ccgauccucu ccugagcucu     1440

gucucccccg gcgccagcaa gacguccucu cgccggagcu ccaugucuau ggaagagaca     1500

gaacacaccu guuga                                                      1515


<210>  2743
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__O75030-9

<400>  2743

Met Leu Glu Met Leu Glu Tyr Asn His Tyr Gln Val Gln Thr His Leu 
1               5                   10                  15      


Glu Asn Pro Thr Lys Tyr His Ile Gln Gln Ala Gln Arg Gln Gln Val 
            20                  25                  30          


Lys Gln Tyr Leu Ser Thr Thr Leu Ala Asn Lys His Ala Asn Gln Val 
        35                  40                  45              


Leu Ser Leu Pro Cys Pro Asn Gln Pro Gly Asp His Val Met Pro Pro 
    50                  55                  60                  


Val Pro Gly Ser Ser Ala Pro Asn Ser Pro Met Ala Met Leu Thr Leu 
65                  70                  75                  80  


Asn Ser Asn Cys Glu Lys Glu Gly Phe Tyr Lys Phe Glu Glu Gln Asn 
                85                  90                  95      


Arg Ala Glu Ser Glu Cys Pro Gly Met Asn Thr His Ser Arg Ala Ser 
            100                 105                 110         


Cys Met Gln Met Asp Asp Val Ile Asp Asp Ile Ile Ser Leu Glu Ser 
        115                 120                 125             


Ser Tyr Asn Glu Glu Ile Leu Gly Leu Met Asp Pro Ala Leu Gln Met 
    130                 135                 140                 


Ala Asn Thr Leu Pro Val Ser Gly Asn Leu Ile Asp Leu Tyr Gly Asn 
145                 150                 155                 160 


Gln Gly Leu Pro Pro Pro Gly Leu Thr Ile Ser Asn Ser Cys Pro Ala 
                165                 170                 175     


Asn Leu Pro Asn Ile Lys Arg Glu Leu Thr Ala Cys Ile Phe Pro Thr 
            180                 185                 190         


Glu Ser Glu Ala Arg Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn 
        195                 200                 205             


His Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile 
    210                 215                 220                 


Lys Glu Leu Gly Thr Leu Ile Pro Lys Ser Asn Asp Pro Asp Met Arg 
225                 230                 235                 240 


Trp Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys 
                245                 250                 255     


Leu Gln Arg Glu Gln Gln Arg Ala Lys Glu Leu Glu Asn Arg Gln Lys 
            260                 265                 270         


Lys Leu Glu His Ala Asn Arg His Leu Leu Leu Arg Ile Gln Glu Leu 
        275                 280                 285             


Glu Met Gln Ala Arg Ala His Gly Leu Ser Leu Ile Pro Ser Thr Gly 
    290                 295                 300                 


Leu Cys Ser Pro Asp Leu Val Asn Arg Ile Ile Lys Gln Glu Pro Val 
305                 310                 315                 320 


Leu Glu Asn Cys Ser Gln Asp Leu Leu Gln His His Ala Asp Leu Thr 
                325                 330                 335     


Cys Thr Thr Thr Leu Asp Leu Thr Asp Gly Thr Ile Thr Phe Asn Asn 
            340                 345                 350         


Asn Leu Gly Thr Gly Thr Glu Ala Asn Gln Ala Tyr Ser Val Pro Thr 
        355                 360                 365             


Lys Met Gly Ser Lys Leu Glu Asp Ile Leu Met Asp Asp Thr Leu Ser 
    370                 375                 380                 


Pro Val Gly Val Thr Asp Pro Leu Leu Ser Ser Val Ser Pro Gly Ala 
385                 390                 395                 400 


Ser Lys Thr Ser Ser Arg Arg Ser Ser Met Ser Met Glu Glu Thr Glu 
                405                 410                 415     


His Thr Cys 
            


<210>  2744
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__CCDS2913.1

<400>  2744
augcuggaaa ugcuagaaua uaaucacuau caggugcaga cccaccucga aaaccccacc       60

aaguaccaca uacagcaagc ccaacggcag cagguaaagc aguaccuuuc uaccacuuua      120

gcaaauaaac augccaacca aguccugagc uugccauguc caaaccagcc uggcgaucau      180

gucaugccac cggugccggg gagcagcgca cccaacagcc ccauggcuau gcuuacgcuu      240

aacuccaacu gugaaaaaga gggauuuuau aaguuugaag agcaaaacag ggcagagagc      300

gagugcccag gcaugaacac acauucacga gcguccugua ugcagaugga ugauguaauc      360

gaugacauca uuagccuaga aucaaguuau aaugaggaaa ucuugggcuu gauggauccu      420

gcuuugcaaa uggcaaauac guugccuguc ucgggaaacu ugauugaucu uuauggaaac      480

caaggucugc ccccaccagg ccucaccauc agcaacuccu guccagccaa ccuucccaac      540

auaaaaaggg agcucacagc guguauuuuu cccacagagu cugaagcaag agcacuggcc      600

aaagagaggc agaaaaagga caaucacaac cugauugaac gaagaagaag auuuaacaua      660

aaugaccgca uuaaagaacu agguacuuug auucccaagu caaaugaucc agacaugcgc      720

uggaacaagg gaaccaucuu aaaagcaucc guggacuaua uccgaaaguu gcaacgagaa      780

cagcaacgcg caaaagaacu ugaaaaccga cagaagaaac uggagcacgc caaccggcau      840

uuguugcuca gaauacagga acuugaaaug caggcucgag cucauggacu uucccuuauu      900

ccauccacgg gucucugcuc uccagauuug gugaaucgga ucaucaagca agaacccguu      960

cuugagaacu gcagccaaga ccuccuucag caucaugcag accuaaccug uacaacaacu     1020

cucgaucuca cggauggcac caucaccuuc aacaacaacc ucggaacugg gacugaggcc     1080

aaccaagccu auaguguccc cacaaaaaug ggauccaaac uggaagacau ccugauggac     1140

gacacccuuu cucccgucgg ugucacugau ccacuccuuu ccucaguguc ccccggagcu     1200

uccaaaacaa gcagccggag gagcaguaug agcauggaag agacggagca cacuuguuag     1260


<210>  2745
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MITF__Homo_sapiens__CCDS2913.1

<400>  2745
augcuggaga ugcucgagua caaccacuac caggugcaga cccaccugga gaaccccacc       60

aaguaccaca uccagcaggc ccagcgccag caggucaagc aguaccugag caccacccuc      120

gccaacaagc acgcgaacca ggugcugucc cugccgugcc ccaaccagcc cggcgaccac      180

gugaugcccc cgguccccgg gagcuccgcc cccaacagcc ccauggccau gcucacccug      240

aacuccaacu gcgagaagga gggcuucuac aaguucgagg agcagaaccg ggccgagagc      300

gagugcccgg ggaugaacac ccacucccgc gccagcugca ugcagaugga cgacgugauc      360

gacgacauca ucucccugga gagcuccuac aacgaggaga uccucggccu gauggacccc      420

gcgcugcaga uggccaacac gcuccccgug agcgggaacc ugaucgaccu guacggcaac      480

cagggccugc ccccgcccgg gcucaccauc uccaacagcu gccccgccaa ccugcccaac      540

aucaagcggg agcucaccgc cugcaucuuc ccgaccgagu ccgaggcgcg cgcccuggcc      600

aaggagcggc agaagaagga caaccacaac cugaucgagc gccggcgccg guucaacauc      660

aacgaccgca ucaaggagcu cggcacgcug auccccaaga gcaacgaccc cgacaugcgg      720

uggaacaagg ggaccauccu gaaggccucc gucgacuaca uccgcaagcu ccagcgggag      780

cagcagcgcg ccaaggagcu ggagaaccgg cagaagaagc uggagcacgc gaaccgccac      840

cuccugcugc ggauccagga gcucgagaug caggcccgcg cccacggccu gagccugauc      900

cccuccaccg ggcucugcag cccggaccug gugaaccgga ucaucaagca ggagcccgug      960

cuggagaacu gcagccagga ccuccugcag caccacgccg accugaccug cacgaccacc     1020

cucgaccuga ccgacggcac gaucaccuuc aacaacaacc ugggcaccgg gaccgaggcc     1080

aaccaggcgu acuccguccc cacgaagaug ggcagcaagc ucgaggacau ccugauggac     1140

gacacccugu cccccguggg ggugaccgac ccgcuccuga gcuccgucag ccccggcgcc     1200

uccaagacca gcucccgccg gagcuccaug agcauggagg agacggagca cacgugcuga     1260


<210>  2746
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MITF__Homo_sapiens__CCDS2913.1

<400>  2746
augcucgaga ugcucgagua caaccacuac cagguccaga cccaccucga gaaccccacc       60

aaguaccaca uccagcaggc ccagcgccag caggucaagc aguaccucuc caccacccuc      120

gccaacaagc acgccaacca gguccucucc cuccccugcc ccaaccagcc cggcgaccac      180

gucaugcccc ccguccccgg cuccuccgcc cccaacuccc ccauggccau gcucacccuc      240

aacuccaacu gcgagaagga gggcuucuac aaguucgagg agcagaaccg cgccgagucc      300

gagugccccg gcaugaacac ccacucccgc gccuccugca ugcagaugga cgacgucauc      360

gacgacauca ucucccucga guccuccuac aacgaggaga uccucggccu cauggacccc      420

gcccuccaga uggccaacac ccuccccguc uccggcaacc ucaucgaccu cuacggcaac      480

cagggccucc ccccccccgg ccucaccauc uccaacuccu gccccgccaa ccuccccaac      540

aucaagcgcg agcucaccgc cugcaucuuc cccaccgagu ccgaggcccg cgcccucgcc      600

aaggagcgcc agaagaagga caaccacaac cucaucgagc gccgccgccg cuucaacauc      660

aacgaccgca ucaaggagcu cggcacccuc auccccaagu ccaacgaccc cgacaugcgc      720

uggaacaagg gcaccauccu caaggccucc gucgacuaca uccgcaagcu ccagcgcgag      780

cagcagcgcg ccaaggagcu cgagaaccgc cagaagaagc ucgagcacgc caaccgccac      840

cuccuccucc gcauccagga gcucgagaug caggcccgcg cccacggccu cucccucauc      900

cccuccaccg gccucugcuc ccccgaccuc gucaaccgca ucaucaagca ggagcccguc      960

cucgagaacu gcucccagga ccuccuccag caccacgccg accucaccug caccaccacc     1020

cucgaccuca ccgacggcac caucaccuuc aacaacaacc ucggcaccgg caccgaggcc     1080

aaccaggccu acuccguccc caccaagaug ggcuccaagc ucgaggacau ccucauggac     1140

gacacccucu cccccgucgg cgucaccgac ccccuccucu ccuccgucuc ccccggcgcc     1200

uccaagaccu ccucccgccg cuccuccaug uccauggagg agaccgagca caccugcuga     1260


<210>  2747
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MITF__Homo_sapiens__CCDS2913.1

<400>  2747
augcuggaga ugcucgaaua caaccacuau caggugcaaa cccaucuuga gaaucccaca       60

aaguaccaca uccagcaggc ccagagacaa caggucaaac aguaucugag cacuacguug      120

gcuaacaagc augcaaauca gguuuuaucc cugccuugcc caaaccaacc gggcgaccac      180

gugaugcccc cuguaccagg gucuucagcc cccaauaguc cuauggcgau gcuaacccuc      240

aacagcaauu gugaaaaaga gggauucuac aaguuugagg aacagaacag ggcugagucc      300

gaaugcccag guaugaauac acauucucgg gccucgugua ugcagaugga ugacgugauu      360

gaugacauaa ucucacugga gagcaguuau aacgaagaga uucuuggccu gauggauccc      420

gcauugcaga uggccaauac ucucccuguc uccgggaacc ugaucgaccu guacggaaau      480

caaggccucc caccgcccgg uuuaaccauu ucuaacagcu gcccugcuaa ucugccaaac      540

aucaaacgcg agcuuacagc auguauauuc cccaccgaau ccgaggcccg agcuuuggcc      600

aaggaacguc agaagaaaga uaaccacaau cugaucgaga gaaggcggcg cuuuaacauu      660

aaugacagaa ucaaggaacu agggacucuc auuccuaaau caaacgaucc agacaugagg      720

uggaauaagg gaacaauccu gaaagcgagu guggauuaua uacggaaacu ucagcgcgag      780

caacagcgag caaaggagcu ggaaaacaga cagaagaagu uggagcacgc caauaggcau      840

cuccuguuac ggauucagga acuggagaug caagcucgug cccacggccu cagccuuauc      900

cccucuaccg gccugugcuc cccggacuug guuaaccgca uuaucaaaca ggaaccugug      960

cuagagaauu guucacagga ucugcuccag caucacgcag accugacgug cacuaccaca     1020

cuugaccuga cugaugggac caucacauuc aacaauaacu ugggaaccgg uacggaggcu     1080

aaucaagccu acagcguccc cacuaagaug ggcaguaaac ucgaagacau ucugauggau     1140

gacacauuau cuccaguggg gguaaccgau ccucugcuau ccagcguuuc gcccggagcg     1200

ucuaagacuu ccucaagaag gaguagcaug uccauggagg aaacagagca caccuguuga     1260


<210>  2748
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MITF__Homo_sapiens__CCDS2913.1

<400>  2748
augcuggaga ugcuggagua caaccacuac caggugcaga cccaccugga gaaccccacc       60

aaguaccaca uccagcaggc ccagagacag caggugaagc aguaccugag caccacccug      120

gccaacaagc acgccaacca ggugcugagc cugcccugcc ccaaccagcc cggcgaccac      180

gugaugcccc ccgugcccgg cagcagcgcc cccaacagcc ccauggccau gcugacccug      240

aacagcaacu gcgagaagga gggcuucuac aaguucgagg agcagaacag agccgagagc      300

gagugccccg gcaugaacac ccacagcaga gccagcugca ugcagaugga cgacgugauc      360

gacgacauca ucagccugga gagcagcuac aacgaggaga uccugggccu gauggacccc      420

gcccugcaga uggccaacac ccugcccgug agcggcaacc ugaucgaccu guacggcaac      480

cagggccugc ccccccccgg ccugaccauc agcaacagcu gccccgccaa ccugcccaac      540

aucaagagag agcugaccgc cugcaucuuc cccaccgaga gcgaggccag agcccuggcc      600

aaggagagac agaagaagga caaccacaac cugaucgaga gaagaagaag auucaacauc      660

aacgacagaa ucaaggagcu gggcacccug auccccaaga gcaacgaccc cgacaugaga      720

uggaacaagg gcaccauccu gaaggccagc guggacuaca ucagaaagcu gcagagagag      780

cagcagagag ccaaggagcu ggagaacaga cagaagaagc uggagcacgc caacagacac      840

cugcugcuga gaauccagga gcuggagaug caggccagag cccacggccu gagccugauc      900

cccagcaccg gccugugcag ccccgaccug gugaacagaa ucaucaagca ggagcccgug      960

cuggagaacu gcagccagga ccugcugcag caccacgccg accugaccug caccaccacc     1020

cuggaccuga ccgacggcac caucaccuuc aacaacaacc ugggcaccgg caccgaggcc     1080

aaccaggccu acagcgugcc caccaagaug ggcagcaagc uggaggacau ccugauggac     1140

gacacccuga gccccguggg cgugaccgac ccccugcuga gcagcgugag ccccggcgcc     1200

agcaagacca gcagcagaag aagcagcaug agcauggagg agaccgagca caccugcuga     1260


<210>  2749
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MITF__Homo_sapiens__CCDS2913.1

<400>  2749
augcuggaga ugcucgaaua caaccacuau caagugcaaa cccaucugga gaaucccaca       60

aaguaccaca uccagcaggc ccagagacaa caggucaaac aguaucuuag cacgacccug      120

gcuaacaagc augccaauca gguucucucc cugccuugcc cgaaccaacc cggcgaccac      180

gugaugccuc ccgugccugg gucuagcgcg cccaauuccc cuauggcuau gcuuacacug      240

aacucuaauu gugaaaaaga gggauucuac aaguuugagg aacagaaccg ggccgagagc      300

gaaugcccgg gcaugaauac ccauucccgc gccucuugua ugcagaugga ugacgucauu      360

gaugacauca uuagccucga guccagcuau aacgaagaga uccuggggcu gauggauccc      420

gcucuccaga uggccaauac acugccugug ucuggaaacc uuauugaccu guacggcaau      480

caagggcuuc ccccucccgg acugaccauc uccaacagcu gcccggcuaa ucuuccuaac      540

aucaaaagag agcugacagc cuguauuuuc cccaccgaau cugaggcgcg ggcccucgcu      600

aaggaacgcc agaagaaaga uaaccacaau cugaucgaga gacggcgcag auuuaacauu      660

aaugaccgga ucaaggaacu gggcacgcuc auuccuaaau ccaacgaucc cgacaugcgc      720

uggaauaagg gcaccauccu gaaagccagc guugauuaua uuagaaagcu ccagcgggag      780

caacagcgcg cuaaggagcu ggaaaacaga cagaaaaagc ucgagcacgc caaucggcau      840

cugcuucugc gcauccagga acucgagaug caagcgagag cccacgggcu gucucugauc      900

cccuccacag gacucugcag cccugaccug gugaaccgga uuaucaaaca ggaaccgguc      960

cuugagaauu guucccagga ucugcuccag caucacgcug accugaccug cacaaccacg     1020

cuugaccuga cagauggcac cauuacauuc aacaauaacc ucgggaccgg aaccgaggcc     1080

aaucaggcuu acucugugcc cacaaagaug ggcagcaaac uggaagacau ccugauggau     1140

gacacgcucu ccccuguugg ggugaccgau ccccugcuua gcucugucuc cccuggagcc     1200

agcaagacau cuagcagacg cuccucuaug agcauggagg aaaccgagca cacauguuga     1260


<210>  2750
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__O75030

<400>  2750

Met Gln Ser Glu Ser Gly Ile Val Pro Asp Phe Glu Val Gly Glu Glu 
1               5                   10                  15      


Phe His Glu Glu Pro Lys Thr Tyr Tyr Glu Leu Lys Ser Gln Pro Leu 
            20                  25                  30          


Lys Ser Ser Ser Ser Ala Glu His Pro Gly Ala Ser Lys Pro Pro Ile 
        35                  40                  45              


Ser Ser Ser Ser Met Thr Ser Arg Ile Leu Leu Arg Gln Gln Leu Met 
    50                  55                  60                  


Arg Glu Gln Met Gln Glu Gln Glu Arg Arg Glu Gln Gln Gln Lys Leu 
65                  70                  75                  80  


Gln Ala Ala Gln Phe Met Gln Gln Arg Val Pro Val Ser Gln Thr Pro 
                85                  90                  95      


Ala Ile Asn Val Ser Val Pro Thr Thr Leu Pro Ser Ala Thr Gln Val 
            100                 105                 110         


Pro Met Glu Val Leu Lys Val Gln Thr His Leu Glu Asn Pro Thr Lys 
        115                 120                 125             


Tyr His Ile Gln Gln Ala Gln Arg Gln Gln Val Lys Gln Tyr Leu Ser 
    130                 135                 140                 


Thr Thr Leu Ala Asn Lys His Ala Asn Gln Val Leu Ser Leu Pro Cys 
145                 150                 155                 160 


Pro Asn Gln Pro Gly Asp His Val Met Pro Pro Val Pro Gly Ser Ser 
                165                 170                 175     


Ala Pro Asn Ser Pro Met Ala Met Leu Thr Leu Asn Ser Asn Cys Glu 
            180                 185                 190         


Lys Glu Gly Phe Tyr Lys Phe Glu Glu Gln Asn Arg Ala Glu Ser Glu 
        195                 200                 205             


Cys Pro Gly Met Asn Thr His Ser Arg Ala Ser Cys Met Gln Met Asp 
    210                 215                 220                 


Asp Val Ile Asp Asp Ile Ile Ser Leu Glu Ser Ser Tyr Asn Glu Glu 
225                 230                 235                 240 


Ile Leu Gly Leu Met Asp Pro Ala Leu Gln Met Ala Asn Thr Leu Pro 
                245                 250                 255     


Val Ser Gly Asn Leu Ile Asp Leu Tyr Gly Asn Gln Gly Leu Pro Pro 
            260                 265                 270         


Pro Gly Leu Thr Ile Ser Asn Ser Cys Pro Ala Asn Leu Pro Asn Ile 
        275                 280                 285             


Lys Arg Glu Leu Thr Ala Cys Ile Phe Pro Thr Glu Ser Glu Ala Arg 
    290                 295                 300                 


Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His Asn Leu Ile Glu 
305                 310                 315                 320 


Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys Glu Leu Gly Thr 
                325                 330                 335     


Leu Ile Pro Lys Ser Asn Asp Pro Asp Met Arg Trp Asn Lys Gly Thr 
            340                 345                 350         


Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu Gln Arg Glu Gln 
        355                 360                 365             


Gln Arg Ala Lys Glu Leu Glu Asn Arg Gln Lys Lys Leu Glu His Ala 
    370                 375                 380                 


Asn Arg His Leu Leu Leu Arg Ile Gln Glu Leu Glu Met Gln Ala Arg 
385                 390                 395                 400 


Ala His Gly Leu Ser Leu Ile Pro Ser Thr Gly Leu Cys Ser Pro Asp 
                405                 410                 415     


Leu Val Asn Arg Ile Ile Lys Gln Glu Pro Val Leu Glu Asn Cys Ser 
            420                 425                 430         


Gln Asp Leu Leu Gln His His Ala Asp Leu Thr Cys Thr Thr Thr Leu 
        435                 440                 445             


Asp Leu Thr Asp Gly Thr Ile Thr Phe Asn Asn Asn Leu Gly Thr Gly 
    450                 455                 460                 


Thr Glu Ala Asn Gln Ala Tyr Ser Val Pro Thr Lys Met Gly Ser Lys 
465                 470                 475                 480 


Leu Glu Asp Ile Leu Met Asp Asp Thr Leu Ser Pro Val Gly Val Thr 
                485                 490                 495     


Asp Pro Leu Leu Ser Ser Val Ser Pro Gly Ala Ser Lys Thr Ser Ser 
            500                 505                 510         


Arg Arg Ser Ser Met Ser Met Glu Glu Thr Glu His Thr Cys 
        515                 520                 525     


<210>  2751
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MITF__Homo_sapiens__XM_005264754

<400>  2751
augcaguccg aaucggggau cgugccggau uucgaagucg gggaggaguu ucaugaagag       60

cccaaaaccu auuacgaacu caaaagucaa ccgcugaaga gcagcaguuc cgccgagcau      120

ccuggggccu ccaagccucc gauaagcucc uccaguauga caucacgcau cuugcuacgc      180

cagcaacuca ugcgugagca gaugcaggag caggagcgca gggagcagca gcagaagcug      240

caggcggccc aguucaugca acagagagug cccgugaguc agacaccagc cauaaacguc      300

agugugccca ccacccuucc cucugccacg caggugccga uggaaguccu uaaggugcag      360

acccaccucg aaaaccccac caaguaccac auacagcaag cccaacggca gcagguaaag      420

caguaccuuu cuaccacuuu agcaaauaaa caugccaacc aaguccugag cuugccaugu      480

ccaaaccagc cuggcgauca ugucaugcca ccggugccgg ggagcagcgc acccaacagc      540

cccauggcua ugcuuacgcu uaacuccaac ugugaaaaag agggauuuua uaaguuugaa      600

gagcaaaaca gggcagagag cgagugccca ggcaugaaca cacauucacg agcguccugu      660

augcagaugg augauguaau cgaugacauc auuagccuag aaucaaguua uaaugaggaa      720

aucuugggcu ugauggaucc ugcuuugcaa auggcaaaua cguugccugu cucgggaaac      780

uugauugauc uuuauggaaa ccaaggucug cccccaccag gccucaccau cagcaacucc      840

uguccagcca accuucccaa cauaaaaagg gagcucacag cguguauuuu ucccacagag      900

ucugaagcaa gagcacuggc caaagagagg cagaaaaagg acaaucacaa ccugauugaa      960

cgaagaagaa gauuuaacau aaaugaccgc auuaaagaac uagguacuuu gauucccaag     1020

ucaaaugauc cagacaugcg cuggaacaag ggaaccaucu uaaaagcauc cguggacuau     1080

auccgaaagu ugcaacgaga acagcaacgc gcaaaagaac uugaaaaccg acagaagaaa     1140

cuggagcacg ccaaccggca uuuguugcuc agaauacagg aacuugaaau gcaggcucga     1200

gcucauggac uuucccuuau uccauccacg ggucucugcu cuccagauuu ggugaaucgg     1260

aucaucaagc aagaacccgu ucuugagaac ugcagccaag accuccuuca gcaucaugca     1320

gaccuaaccu guacaacaac ucucgaucuc acggauggca ccaucaccuu caacaacaac     1380

cucggaacug ggacugaggc caaccaagcc uauagugucc ccacaaaaau gggauccaaa     1440

cuggaagaca uccugaugga cgacacccuu ucucccgucg gugucacuga uccacuccuu     1500

uccucagugu cccccggagc uuccaaaaca agcagccgga ggagcaguau gagcauggaa     1560

gagacggagc acacuuguua g                                               1581


<210>  2752
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MITF__Homo_sapiens__XM_005264754

<400>  2752
augcagagcg aguccggcau cgugcccgac uucgaggucg gggaggaguu ccacgaggag       60

ccgaagaccu acuacgagcu caagagccag ccccucaagu ccagcuccag cgccgagcac      120

cccggcgccu ccaagccccc gaucagcucc agcuccauga ccagccgcau ccugcugcgg      180

cagcagcuca ugcgcgagca gaugcaggag caggagcggc gcgagcagca gcagaagcug      240

caggcggccc aguucaugca gcagcgggug cccguguccc agacccccgc caucaacguc      300

agcgugccca ccacccugcc guccgccacc caggugccca uggagguccu caaggugcag      360

acgcaccugg agaaccccac caaguaccac auccagcagg cccagcgcca gcaggucaag      420

caguaccuga gcaccacccu cgcgaacaag cacgccaacc aggugcuguc ccugcccugc      480

ccgaaccagc ccggggacca cgugaugccg cccgugcccg gcagcuccgc ccccaacagc      540

cccauggcca ugcucacgcu gaacagcaac ugcgagaagg agggguucua caaguucgag      600

gagcagaacc gggcggaguc cgagugcccc ggcaugaaca cccacagccg cgccuccugc      660

augcagaugg acgacgucau cgacgacauc aucagccugg aguccagcua caacgaggag      720

auccucggcc ugauggaccc ggcccugcag auggccaaca cccuccccgu guccgggaac      780

cugaucgacc uguacggcaa ccaggggcug cccccgcccg gccugaccau cagcaacucc      840

ugccccgcca accugcccaa caucaagcgg gagcucacgg cgugcaucuu ccccaccgag      900

agcgaggccc gcgcccuggc caaggagcgg cagaagaagg acaaccacaa ccugaucgag      960

cgccggcgcc gguucaacau caacgaccgc aucaaggagc ucgggacccu gaucccgaag     1020

uccaacgacc ccgacaugcg guggaacaag ggcaccaucc ugaaggccag cguggacuac     1080

auccgcaagc uccagcggga gcagcagcgc gcgaaggagc uggagaaccg gcagaagaag     1140

cuggagcacg ccaaccgcca ccuccugcug cgcauccagg agcucgagau gcaggcccgg     1200

gcccacggcc ugucccugau ccccagcacg gggcucugcu ccccggaccu ggucaaccgc     1260

aucaucaagc aggagcccgu gcuggagaac ugcagccagg accuccugca gcaccacgcc     1320

gaccugaccu gcaccaccac gcucgaccug accgacggca ccaucaccuu caacaacaac     1380

cuggggacgg gcaccgaggc gaaccaggcc uacuccgugc ccaccaagau gggcagcaag     1440

cucgaggaca uccugaugga cgacacccug ucccccgucg gggugacgga cccgcugcuc     1500

agcagcgugu cccccggcgc cagcaagacc uccagccggc gcuccagcau guccauggag     1560

gagaccgagc acacgugcug a                                               1581


<210>  2753
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MITF__Homo_sapiens__XM_005264754

<400>  2753
augcaguccg aguccggcau cguccccgac uucgaggucg gcgaggaguu ccacgaggag       60

cccaagaccu acuacgagcu caagucccag ccccucaagu ccuccuccuc cgccgagcac      120

cccggcgccu ccaagccccc caucuccucc uccuccauga ccucccgcau ccuccuccgc      180

cagcagcuca ugcgcgagca gaugcaggag caggagcgcc gcgagcagca gcagaagcuc      240

caggccgccc aguucaugca gcagcgcguc cccgucuccc agacccccgc caucaacguc      300

uccgucccca ccacccuccc cuccgccacc caggucccca uggagguccu caagguccag      360

acccaccucg agaaccccac caaguaccac auccagcagg cccagcgcca gcaggucaag      420

caguaccucu ccaccacccu cgccaacaag cacgccaacc agguccucuc ccuccccugc      480

cccaaccagc ccggcgacca cgucaugccc cccguccccg gcuccuccgc ccccaacucc      540

cccauggcca ugcucacccu caacuccaac ugcgagaagg agggcuucua caaguucgag      600

gagcagaacc gcgccgaguc cgagugcccc ggcaugaaca cccacucccg cgccuccugc      660

augcagaugg acgacgucau cgacgacauc aucucccucg aguccuccua caacgaggag      720

auccucggcc ucauggaccc cgcccuccag auggccaaca cccuccccgu cuccggcaac      780

cucaucgacc ucuacggcaa ccagggccuc cccccccccg gccucaccau cuccaacucc      840

ugccccgcca accuccccaa caucaagcgc gagcucaccg ccugcaucuu ccccaccgag      900

uccgaggccc gcgcccucgc caaggagcgc cagaagaagg acaaccacaa ccucaucgag      960

cgccgccgcc gcuucaacau caacgaccgc aucaaggagc ucggcacccu cauccccaag     1020

uccaacgacc ccgacaugcg cuggaacaag ggcaccaucc ucaaggccuc cgucgacuac     1080

auccgcaagc uccagcgcga gcagcagcgc gccaaggagc ucgagaaccg ccagaagaag     1140

cucgagcacg ccaaccgcca ccuccuccuc cgcauccagg agcucgagau gcaggcccgc     1200

gcccacggcc ucucccucau ccccuccacc ggccucugcu cccccgaccu cgucaaccgc     1260

aucaucaagc aggagcccgu ccucgagaac ugcucccagg accuccucca gcaccacgcc     1320

gaccucaccu gcaccaccac ccucgaccuc accgacggca ccaucaccuu caacaacaac     1380

cucggcaccg gcaccgaggc caaccaggcc uacuccgucc ccaccaagau gggcuccaag     1440

cucgaggaca uccucaugga cgacacccuc ucccccgucg gcgucaccga cccccuccuc     1500

uccuccgucu cccccggcgc cuccaagacc uccucccgcc gcuccuccau guccauggag     1560

gagaccgagc acaccugcug a                                               1581


<210>  2754
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MITF__Homo_sapiens__XM_005264754

<400>  2754
augcaaagcg aguccggcau cgugcccgac uucgaagucg gggaggaauu ucacgaggaa       60

ccuaagaccu acuaugagcu gaaaucucaa ccacucaagu caaguagcuc cgccgagcau      120

ccgggagcuu cuaaaccccc uauuucguca agcaguauga cauccagaau acuucugagg      180

cagcaguuga ugcgggaaca gaugcaagag caggaacgcc gagagcagca gcaaaaguua      240

caggcagccc aguucaugca gcaacguguu ccagugucuc agacucccgc gaucaacgua      300

agcgugccua cgacccugcc auccgcuaca caggucccca uggaggugcu aaaaguucaa      360

acucaccucg aaaauccuac caaguaccau auucagcagg cccagagaca acaggugaag      420

caguaucugu caacaacccu ugcaaacaaa cacgccaauc agguccugag uuugccaugc      480

ccgaaccaac ccggugauca ugugaugccu ccaguacccg gcagcucugc uccuaauucc      540

ccaauggcaa ugcucacucu gaacucaaau ugugagaagg aaggguuuua caaauucgag      600

gaacagaaca gggccgagag cgagugcccc ggaaugaaua cacacagucg ggcuucuugu      660

augcagaugg acgauguuau cgacgauauu aucucccugg aaagcucgua uaacgaggaa      720

auacucggcu uaauggaccc ggcccugcag auggcgaaua cccuuccugu gucugguaac      780

uugaucgauc uguacgggaa ucaaggacua cccccaccug gccucacgau uuccaacuca      840

ugccccgcaa aucugccaaa caucaagcgc gagcuuacug ccuguauuuu ucccaccgaa      900

agugaggcua gagcccuggc aaaagagagg cagaagaagg acaaccacaa uuugaucgaa      960

cggcgccgaa gauucaacau aaaugauagg auuaaagagc ucggcacacu gaucccuaag     1020

agcaacgacc cagauaugcg guggaauaaa gggacuauuu uaaaggcuuc cgucgacuau     1080

auccguaaac ugcagcgcga acagcaaaga gccaaggagc ucgaaaacag gcagaaaaag     1140

cuggagcaug cgaaucggca ccuuuugcua cgaauccagg agcuggaaau gcaagcccgc     1200

gcacauggac ucucucugau uccgagcacc ggucuuugcu cacccgaucu ggugaacaga     1260

auaaucaagc aggagccugu guuggaaaau uguagucagg accuccugca gcaccacgcu     1320

gacuuaacau gcaccacgac ucuggaucua acagacggca ccauuacuuu uaacaauaac     1380

cucgggacag gaaccgaggc caaucaggcu uacuccgucc caacgaaaau gggcagcaag     1440

cuggaggaua uccuuaugga cgauaccuug ucucccguug gugugacaga cccucugcuc     1500

ucaaguguaa gcccaggggc cuccaaaacu ucuucgaggc ggagcuccau gucaauggaa     1560

gagaccgaac auacauguug a                                               1581


<210>  2755
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MITF__Homo_sapiens__XM_005264754

<400>  2755
augcagagcg agagcggcau cgugcccgac uucgaggugg gcgaggaguu ccacgaggag       60

cccaagaccu acuacgagcu gaagagccag ccccugaaga gcagcagcag cgccgagcac      120

cccggcgcca gcaagccccc caucagcagc agcagcauga ccagcagaau ccugcugaga      180

cagcagcuga ugagagagca gaugcaggag caggagagaa gagagcagca gcagaagcug      240

caggccgccc aguucaugca gcagagagug cccgugagcc agacccccgc caucaacgug      300

agcgugccca ccacccugcc cagcgccacc caggugccca uggaggugcu gaaggugcag      360

acccaccugg agaaccccac caaguaccac auccagcagg cccagagaca gcaggugaag      420

caguaccuga gcaccacccu ggccaacaag cacgccaacc aggugcugag ccugcccugc      480

cccaaccagc ccggcgacca cgugaugccc cccgugcccg gcagcagcgc ccccaacagc      540

cccauggcca ugcugacccu gaacagcaac ugcgagaagg agggcuucua caaguucgag      600

gagcagaaca gagccgagag cgagugcccc ggcaugaaca cccacagcag agccagcugc      660

augcagaugg acgacgugau cgacgacauc aucagccugg agagcagcua caacgaggag      720

auccugggcc ugauggaccc cgcccugcag auggccaaca cccugcccgu gagcggcaac      780

cugaucgacc uguacggcaa ccagggccug cccccccccg gccugaccau cagcaacagc      840

ugccccgcca accugcccaa caucaagaga gagcugaccg ccugcaucuu ccccaccgag      900

agcgaggcca gagcccuggc caaggagaga cagaagaagg acaaccacaa ccugaucgag      960

agaagaagaa gauucaacau caacgacaga aucaaggagc ugggcacccu gauccccaag     1020

agcaacgacc ccgacaugag auggaacaag ggcaccaucc ugaaggccag cguggacuac     1080

aucagaaagc ugcagagaga gcagcagaga gccaaggagc uggagaacag acagaagaag     1140

cuggagcacg ccaacagaca ccugcugcug agaauccagg agcuggagau gcaggccaga     1200

gcccacggcc ugagccugau ccccagcacc ggccugugca gccccgaccu ggugaacaga     1260

aucaucaagc aggagcccgu gcuggagaac ugcagccagg accugcugca gcaccacgcc     1320

gaccugaccu gcaccaccac ccuggaccug accgacggca ccaucaccuu caacaacaac     1380

cugggcaccg gcaccgaggc caaccaggcc uacagcgugc ccaccaagau gggcagcaag     1440

cuggaggaca uccugaugga cgacacccug agccccgugg gcgugaccga cccccugcug     1500

agcagcguga gccccggcgc cagcaagacc agcagcagaa gaagcagcau gagcauggag     1560

gagaccgagc acaccugcug a                                               1581


<210>  2756
<211>  1581
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MITF__Homo_sapiens__XM_005264754

<400>  2756
augcaaagcg aguccggcau cgugcccgac uucgaagucg gggaggaauu ucacgaggaa       60

ccuaagaccu acuaugagcu gaaaucucaa ccgcucaaga gcuccucuag cgccgagcau      120

cccggagcuu ccaaaccucc cauuucuagc uccagcauga caucuagaau ccugcuucgg      180

cagcagcuga ugcgcgaaca gaugcaagag caggaaagac gggagcagca gcaaaagcuc      240

caggccgcgc aguucaugca gcaacgcguu ccuguguccc agacgcccgc uauuaacgug      300

agcgucccua ccacacugcc gucugccacc caggugccca uggagguucu uaaagugcaa      360

acacaccugg aaaauccuac caaguaccau auccagcagg cccagagaca acaggucaag      420

caguaucucu ccacaacccu ggcuaacaaa cacgccaauc aggugcugag ccuccccugc      480

ccuaaccaac ccggcgauca uguuaugccg ccugugcccg ggucuuccgc uccuaauagc      540

cccauggcca ugcugacgcu uaacuccaau ugugagaagg aaggauuuua caaauucgag      600

gaacagaacc gggcggaguc ugagugcccc ggcaugaaua cccacagccg cgccuccugu      660

augcagaugg acgaugucau ugacgauauc aucagccugg aaucuuccua uaacgaggaa      720

auucucgggc ugauggaccc ugcccuucag auggcuaaua cacugccggu gagcggaaac      780

cucaucgauc uguacggcaa ucaaggccug cccccucccg ggcucaccau uucuaacagc      840

ugcccugcua aucugcccaa caucaagaga gagcuuacag ccuguauuuu uccgaccgaa      900

uccgaggcgc gggcccuggc uaaagagcgc cagaagaagg acaaccacaa ucucaucgaa      960

agacggcgca gauucaacau uaaugaucgg aucaaagagc ugggaacgcu uaucccuaag     1020

ucuaacgacc ccgauaugcg cuggaauaaa ggcacaauuc ugaaggccag cguggacuau     1080

aucagaaaac uccagcggga acagcaaaga gcuaaggagc uggaaaaccg ccagaaaaag     1140

cuggagcaug ccaaucggca ccuccugcuu cgcauucagg agcuggaaau gcaagccaga     1200

gcucaugggc ucucccugau cccuagcacc ggacuuugcu cucccgaucu ggucaaccgg     1260

auuaucaagc aggagccugu ucucgaaaau uguucccagg accugcugca gcaccacgcg     1320

gaccucacau gcaccaccac acuggaucuu acggacggca ccaucacauu uaacaauaac     1380

cuggggaccg gaacagaggc caaucaggcu uacagcgugc ccaccaaaau gggcucuaag     1440

cucgaggaua uucugaugga cgauacgcug uccccggugg gcgucacaga cccucuucuc     1500

agcuccgugu cucccggggc cagcaaaacc uccucuagac gcagcuccau gagcauggaa     1560

gagaccgaac auacauguug a                                               1581


<210>  2757
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MMP1_1__Homo_sapiens__B3KQS8

<400>  2757

Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu 
1               5                   10                  15      


Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg 
            20                  25                  30          


Ala Leu Pro Pro Asp Val His His Leu His Ala Glu Arg Arg Gly Pro 
        35                  40                  45              


Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala 
    50                  55                  60                  


Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys 
65                  70                  75                  80  


Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys 
                85                  90                  95      


Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln 
            100                 105                 110         


Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr 
        115                 120                 125             


Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala 
    130                 135                 140                 


Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile 
145                 150                 155                 160 


Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His 
                165                 170                 175     


Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp 
            180                 185                 190         


Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln 
        195                 200                 205             


His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg 
    210                 215                 220                 


Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu 
225                 230                 235                 240 


Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly 
                245                 250                 255     


Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp 
            260                 265                 270         


Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile 
        275                 280                 285             


Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg 
    290                 295                 300                 


Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp 
305                 310                 315                 320 


Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly 
                325                 330                 335     


His Ile Trp Phe Phe Gln Gly Thr Thr Gly Val Ser Thr Pro Ala Pro 
            340                 345                 350         


Gly Val 
        


<210>  2758
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MMP1_1__Homo_sapiens__BAG52140

<400>  2758
auggcuccgg ccgccuggcu ccgcagcgcg gccgcgcgcg cccuccugcc cccgaugcug       60

cugcugcugc uccagccgcc gccgcugcug gcccgggcuc ugccgccgga cguccaccac      120

cuccaugccg agaggagggg gccacagccc uggcaugcag cccugcccag uagcccggca      180

ccugccccug ccacgcagga agccccccgg ccugccagca gccucaggcc uccccgcugu      240

ggcgugcccg acccaucuga ugggcugagu gcccgcaacc gacagaagag gauccuucgg      300

uucccauggc aguuggugca ggagcaggug cggcagacga uggcagaggc ccuaaaggua      360

uggagcgaug ugacgccacu caccuuuacu gaggugcacg agggccgugc ugacaucaug      420

aucgacuucg ccagguacug gcauggggac gaccugccgu uugaugggcc ugggggcauc      480

cuggcccaug ccuucuuccc caagacucac cgagaagggg auguccacuu cgacuaugau      540

gagaccugga cuaucgggga ugaccagggc acagaccugc ugcagguggc agcccaugaa      600

uuuggccacg ugcuggggcu gcagcacaca acagcagcca aggcccugau guccgccuuc      660

uacaccuuuc gcuacccacu gagucucagc ccagaugacu gcaggggcgu ucaacaccua      720

uauggccagc ccuggcccac ugucaccucc aggaccccag cccugggccc ccaggcuggg      780

auagacacca augagauugc accgcuggag ccagacgccc cgccagaugc cugugaggcc      840

uccuuugacg cggucuccac cauccgaggc gagcucuuuu ucuucaaagc gggcuuugug      900

uggcgccucc gugggggcca gcugcagccc ggcuacccag cauuggccuc ucgccacugg      960

cagggacugc ccagcccugu ggacgcugcc uucgaggaug cccagggcca cauuugguuc     1020

uuccaaggga cuacuggcgu uuccacccca gcacccggcg uguag                     1065


<210>  2759
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MMP1_1__Homo_sapiens__BAG52140

<400>  2759
auggcccccg ccgcguggcu gcgcagcgcc gccgcccggg cccuccugcc gcccaugcug       60

cuccugcugc uccagccccc cccgcugcug gcgcgcgccc ucccccccga cgugcaccac      120

cugcacgccg agcggcgcgg cccccagccg uggcacgccg cgcugcccuc cagccccgcc      180

cccgccccgg ccacccagga ggccccccgg cccgcgucca gccuccgccc cccgcggugc      240

gggguccccg accccuccga cggccugagc gcccgcaacc ggcagaagcg cauccugcgg      300

uuccccuggc agcucgugca ggagcaggug cgccagacca uggccgaggc ccugaagguc      360

ugguccgacg ugacgccgcu gaccuucacc gaggugcacg aggggcgggc cgacaucaug      420

aucgacuucg cgcgcuacug gcacggcgac gaccuccccu ucgacgggcc cggcggcauc      480

cuggcccacg ccuucuuccc caagacccac cgggaggggg acguccacuu cgacuacgac      540

gagacgugga ccaucggcga cgaccagggg accgaccugc uccagguggc cgcccacgag      600

uucggccacg ugcuggggcu gcagcacacc acggcggcca aggcccucau gagcgccuuc      660

uacaccuucc gcuacccgcu gucccugagc cccgacgacu gccggggcgu ccagcaccuc      720

uacggccagc ccuggcccac cgugaccucc cgcacgccgg cccuggggcc ccaggcgggc      780

aucgacacca acgagaucgc cccccuggag ccggacgccc cccccgacgc cugcgaggcg      840

agcuucgacg ccguguccac cauccggggg gagcucuucu ucuucaaggc cggcuucguc      900

uggcgccugc ggggcgggca gcugcagccc ggcuacccgg cccucgccag ccgccacugg      960

caggggcugc ccucccccgu ggacgcggcc uucgaggacg cccagggcca caucugguuc     1020

uuccagggga ccacgggcgu gagcaccccc gccccgggcg ucuga                     1065


<210>  2760
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MMP1_1__Homo_sapiens__BAG52140

<400>  2760
auggcccccg ccgccuggcu ccgcuccgcc gccgcccgcg cccuccuccc ccccaugcuc       60

cuccuccucc uccagccccc cccccuccuc gcccgcgccc ucccccccga cguccaccac      120

cuccacgccg agcgccgcgg cccccagccc uggcacgccg cccuccccuc cucccccgcc      180

cccgcccccg ccacccagga ggccccccgc cccgccuccu cccuccgccc cccccgcugc      240

ggcguccccg accccuccga cggccucucc gcccgcaacc gccagaagcg cauccuccgc      300

uuccccuggc agcucgucca ggagcagguc cgccagacca uggccgaggc ccucaagguc      360

ugguccgacg ucaccccccu caccuucacc gagguccacg agggccgcgc cgacaucaug      420

aucgacuucg cccgcuacug gcacggcgac gaccuccccu ucgacggccc cggcggcauc      480

cucgcccacg ccuucuuccc caagacccac cgcgagggcg acguccacuu cgacuacgac      540

gagaccugga ccaucggcga cgaccagggc accgaccucc uccaggucgc cgcccacgag      600

uucggccacg uccucggccu ccagcacacc accgccgcca aggcccucau guccgccuuc      660

uacaccuucc gcuacccccu cucccucucc cccgacgacu gccgcggcgu ccagcaccuc      720

uacggccagc ccuggcccac cgucaccucc cgcacccccg cccucggccc ccaggccggc      780

aucgacacca acgagaucgc cccccucgag cccgacgccc cccccgacgc cugcgaggcc      840

uccuucgacg ccgucuccac cauccgcggc gagcucuucu ucuucaaggc cggcuucguc      900

uggcgccucc gcggcggcca gcuccagccc ggcuaccccg cccucgccuc ccgccacugg      960

cagggccucc ccucccccgu cgacgccgcc uucgaggacg cccagggcca caucugguuc     1020

uuccagggca ccaccggcgu cuccaccccc gcccccggcg ucuga                     1065


<210>  2761
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MMP1_1__Homo_sapiens__BAG52140

<400>  2761
auggcccccg cugcauggcu gagaagcgcc gcggcuaggg cccuccuucc uccaaugcug       60

uuguuacugc uacagccgcc cccucuccug gcacgggccc uuccacccga cgugcaccau      120

cugcacgcug agcgccgagg cccucaacca uggcaugcag ccuugcccuc cucuccugcu      180

ccagccccgg cgacccagga agcaccccgu ccugccucaa gucucagacc acccaggugc      240

ggggucccug auccaagcga cggacugucc gcucggaacc gccagaagag aauccugagg      300

uuccccuggc agcucguuca agaacaggug cggcagacaa uggccgaggc auuaaaagua      360

uggucugaug ugacuccgcu gacguuuacc gagguccacg aaggucgcgc ugacauuaug      420

auagauuucg cccgauacug gcauggcgac gaucuuccuu uugacgggcc cggaggcauc      480

uuggcgcacg ccuucuuucc aaagacacac agagagggug augugcauuu cgacuaugau      540

gagacuugga ccauugggga cgaucaggga acagaccugc uacaaguugc agcucacgaa      600

uuuggccaug ugcucggccu gcagcacacc acugccgcua aagcccuuau gucggcauuc      660

uacacauuua gguauccucu gucauugagc cccgacgauu gucguggggu ccagcaccuc      720

uacggacagc cauggcccac cgugacgagu cggacuccug cccugggucc acaagcuggc      780

aucgacacca augagauugc gccguuagaa cccgaugcac cuccagacgc cugcgaggcu      840

uccuucgaug ccguaucuac aauccgcggg gagcuguuuu ucuuuaaggc aggauucguu      900

uggagacuca ggggcgguca gcuucagccc ggguauccug cccuggcuag ccggcauugg      960

caaggauugc caucccccgu ggacgccgca uucgaagaug cgcagggcca cauaugguuu     1020

uuccagggca cuaccggggu cucaacaccg gcuccuggag uguga                     1065


<210>  2762
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MMP1_1__Homo_sapiens__BAG52140

<400>  2762
auggcccccg ccgccuggcu gagaagcgcc gccgccagag cccugcugcc ccccaugcug       60

cugcugcugc ugcagccccc cccccugcug gccagagccc ugccccccga cgugcaccac      120

cugcacgccg agagaagagg cccccagccc uggcacgccg cccugcccag cagccccgcc      180

cccgcccccg ccacccagga ggcccccaga cccgccagca gccugagacc ccccagaugc      240

ggcgugcccg accccagcga cggccugagc gccagaaaca gacagaagag aauccugaga      300

uuccccuggc agcuggugca ggagcaggug agacagacca uggccgaggc ccugaaggug      360

uggagcgacg ugaccccccu gaccuucacc gaggugcacg agggcagagc cgacaucaug      420

aucgacuucg ccagauacug gcacggcgac gaccugcccu ucgacggccc cggcggcauc      480

cuggcccacg ccuucuuccc caagacccac agagagggcg acgugcacuu cgacuacgac      540

gagaccugga ccaucggcga cgaccagggc accgaccugc ugcagguggc cgcccacgag      600

uucggccacg ugcugggccu gcagcacacc accgccgcca aggcccugau gagcgccuuc      660

uacaccuuca gauacccccu gagccugagc cccgacgacu gcagaggcgu gcagcaccug      720

uacggccagc ccuggcccac cgugaccagc agaacccccg cccugggccc ccaggccggc      780

aucgacacca acgagaucgc cccccuggag cccgacgccc cccccgacgc cugcgaggcc      840

agcuucgacg ccgugagcac caucagaggc gagcuguucu ucuucaaggc cggcuucgug      900

uggagacuga gaggcggcca gcugcagccc ggcuaccccg cccuggccag cagacacugg      960

cagggccugc ccagccccgu ggacgccgcc uucgaggacg cccagggcca caucugguuc     1020

uuccagggca ccaccggcgu gagcaccccc gcccccggcg uguga                     1065


<210>  2763
<211>  1065
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MMP1_1__Homo_sapiens__BAG52140

<400>  2763
auggcccccg cugccuggcu gagaagcgcg gcugcccggg cccuccugcc uccgaugcuu       60

cugcuccugc uucagccccc uccccugcuc gcucgcgccc ugccucccga cgugcaccau      120

cugcacgcug agagacgggg cccucaaccg uggcaugccg cgcuccccuc cucuccugcc      180

cccgcuccug ccacacagga agcuccccgc ccggccagcu cccugagacc uccccggugc      240

ggggucccug aucccucuga cggacuuagc gcgcgcaaca gacagaagcg gauccugcgc      300

uuccccuggc agcucguuca agaacaggug agacagacaa uggccgaggc ucugaaagug      360

ugguccgaug ucacgccucu uaccuuuaca gaggugcacg aaggccgggc cgacauuaug      420

aucgauuucg cucgcuacug gcauggggac gaucugccgu uugacggacc cggcgggauu      480

cucgcccacg ccuucuuucc uaagacccac agagagggag auguucauuu cgacuaugau      540

gagacaugga ccaucggcga cgaucagggc acagaccugc ugcaaguggc ugcgcacgaa      600

uuugggcaug uccucggacu gcagcacacc acggccgcua aagcccuuau gucugccuuc      660

uacaccuuuc gguauccccu gagccucucc ccugacgauu gucgcggcgu gcagcaccug      720

uacgggcagc ccuggccgac aguuaccagc agaaccccug cucuuggacc ccaagccggc      780

auugacacaa augagaucgc gccucuggaa cccgaugcuc cucccgacgc cugcgaggcc      840

ucuuucgaug cuguguccac gaucagaggg gagcucuuuu ucuuuaaggc cggauucguc      900

uggcggcugc gcggcggcca gcugcagccg ggguauccug cucucgccag ccggcauugg      960

caaggacugc ccucucccgu ggacgcggcc uucgaagaug cucagggcca cauuugguuu     1020

uuccagggga caaccggagu guccaccccu gccccgggcg ucuga                     1065


<210>  2764
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MMP7__Homo_sapiens__P09237

<400>  2764

Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 
            20                  25                  30          


Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 
        35                  40                  45              


Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 
                85                  90                  95      


Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 
            100                 105                 110         


Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 
        115                 120                 125             


Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 
    130                 135                 140                 


Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 
        195                 200                 205             


Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 


Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            260                 265         


<210>  2765
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MMP7__Homo_sapiens__AAV40839

<400>  2765
augcgacuca ccgugcugug ugcugugugc cugcugccug gcagccuggc ccugccgcug       60

ccucaggagg cgggaggcau gagugagcua cagugggaac aggcucagga cuaucucaag      120

agauuuuauc ucuaugacuc agaaacaaaa aaugccaaca guuuagaagc caaacucaag      180

gagaugcaaa aauucuuugg ccuaccuaua acuggaaugu uaaacucccg cgucauagaa      240

auaaugcaga agcccagaug uggagugcca gauguugcag aauacucacu auuuccaaau      300

agcccaaaau ggacuuccaa aguggucacc uacaggaucg uaucauauac ucgagacuua      360

ccgcauauua caguggaucg auuaguguca aaggcuuuaa acaugugggg caaagagauc      420

ccccugcauu ucaggaaagu uguaugggga acugcugaca ucaugauugg cuuugcgcga      480

ggagcucaug gggacuccua cccauuugau gggccaggaa acacgcuggc ucaugccuuu      540

gcgccuggga caggucucgg aggagaugcu cacuucgaug aggaugaacg cuggacggau      600

gguagcaguc uagggauuaa cuuccuguau gcugcaacuc augaacuugg ccauucuuug      660

gguaugggac auuccucuga uccuaaugca gugauguauc caaccuaugg aaauggagau      720

ccccaaaauu uuaaacuuuc ccaggaugau auuaaaggca uucagaaacu auauggaaag      780

agaaguaauu caagaaagaa auag                                             804


<210>  2766
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MMP7__Homo_sapiens__AAV40839

<400>  2766
augcgccuga ccgugcucug cgccgucugc cugcugcccg gcagccucgc ccugccgcug       60

ccccaggagg ccgggggcau guccgagcuc cagugggagc aggcgcagga cuaccugaag      120

cgguucuacc uguacgacag cgagaccaag aacgccaacu cccucgaggc caagcugaag      180

gagaugcaga aguucuucgg gcugcccauc acgggcaugc ucaacagccg cgugaucgag      240

aucaugcaga agccccggug cggggugccg gacgucgccg aguacucccu guuccccaac      300

agccccaagu ggaccuccaa gguggugacc uaccgcaucg ucagcuacac ccgggaccug      360

ccccacauca cgguggaccg ccucgugucc aaggcgcuga acaugugggg caaggagauc      420

ccgcugcacu uccggaaggu cguguggggc accgccgaca ucaugaucgg guucgcccgc      480

ggcgcccacg gggacagcua ccccuucgac ggccccggga acacccucgc gcacgccuuc      540

gcccccggca ccggccucgg gggcgacgcc cacuucgacg aggacgagcg guggacggac      600

ggguccagcc ugggcaucaa cuuccuguac gccgcgaccc acgagcuggg ccacucccug      660

gggaugggcc acagcuccga cccgaacgcc gugauguacc ccaccuacgg gaacggcgac      720

ccccagaacu ucaagcucag ccaggacgac aucaagggga uccagaagcu guacggcaag      780

cgcuccaaca gccggaagaa guga                                             804


<210>  2767
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MMP7__Homo_sapiens__AAV40839

<400>  2767
augcgccuca ccguccucug cgccgucugc cuccuccccg gcucccucgc ccucccccuc       60

ccccaggagg ccggcggcau guccgagcuc cagugggagc aggcccagga cuaccucaag      120

cgcuucuacc ucuacgacuc cgagaccaag aacgccaacu cccucgaggc caagcucaag      180

gagaugcaga aguucuucgg ccuccccauc accggcaugc ucaacucccg cgucaucgag      240

aucaugcaga agccccgcug cggcgucccc gacgucgccg aguacucccu cuuccccaac      300

ucccccaagu ggaccuccaa ggucgucacc uaccgcaucg ucuccuacac ccgcgaccuc      360

ccccacauca ccgucgaccg ccucgucucc aaggcccuca acaugugggg caaggagauc      420

ccccuccacu uccgcaaggu cgucuggggc accgccgaca ucaugaucgg cuucgcccgc      480

ggcgcccacg gcgacuccua ccccuucgac ggccccggca acacccucgc ccacgccuuc      540

gcccccggca ccggccucgg cggcgacgcc cacuucgacg aggacgagcg cuggaccgac      600

ggcuccuccc ucggcaucaa cuuccucuac gccgccaccc acgagcucgg ccacucccuc      660

ggcaugggcc acuccuccga ccccaacgcc gucauguacc ccaccuacgg caacggcgac      720

ccccagaacu ucaagcucuc ccaggacgac aucaagggca uccagaagcu cuacggcaag      780

cgcuccaacu cccgcaagaa guga                                             804


<210>  2768
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MMP7__Homo_sapiens__AAV40839

<400>  2768
augagacuga ccgugcucug cgccgucugu cuucugcccg gcagcuuggc uuuaccucug       60

ccacaggagg cagggggaau guccgaacua caaugggagc aggcccagga cuaccucaag      120

agguucuauc uguacgauuc ugaaacaaag aacgcuaauu cacuugaggc gaagcugaaa      180

gaaaugcaga aguuuuucgg uuugccgauc acuggcaugc ucaacagucg gguuauugag      240

auaaugcaaa aaccccgcug cggggugccu gacguagccg aguauagccu guuuccaaau      300

ucccccaagu ggacgucuaa gguggucacc uaccgaaucg ugucguauac acgugaucug      360

ccucacauua cuguugacag acucguguca aaagcauuaa acaugugggg aaaggaaauc      420

ccacugcauu ucaggaaagu cguguggggc accgccgaua uuaugaucgg uuuugcucgc      480

ggggcacacg gagacagcua ccccuucgau ggcccuggca auacacuugc ccaugcuuuu      540

gccccaggga ccggauuggg uggcgacgcg cacuucgaug aggacgaacg guggacugau      600

gggaguuccc ugggaauaaa cuuucuauau gcagccacac augagcucgg ccacucucug      660

gguauggggc acagcuccga cccgaaugcu guaauguacc ccaccuacgg aaacggcgau      720

ccucagaauu ucaaacuuuc acaggacgac aucaaaggca uucagaagcu guaugggaag      780

agaaguaaca gcaggaaaaa guga                                             804


<210>  2769
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MMP7__Homo_sapiens__AAV40839

<400>  2769
augagacuga ccgugcugug cgccgugugc cugcugcccg gcagccuggc ccugccccug       60

ccccaggagg ccggcggcau gagcgagcug cagugggagc aggcccagga cuaccugaag      120

agauucuacc uguacgacag cgagaccaag aacgccaaca gccuggaggc caagcugaag      180

gagaugcaga aguucuucgg ccugcccauc accggcaugc ugaacagcag agugaucgag      240

aucaugcaga agcccagaug cggcgugccc gacguggccg aguacagccu guuccccaac      300

agccccaagu ggaccagcaa gguggugacc uacagaaucg ugagcuacac cagagaccug      360

ccccacauca ccguggacag acuggugagc aaggcccuga acaugugggg caaggagauc      420

ccccugcacu ucagaaaggu gguguggggc accgccgaca ucaugaucgg cuucgccaga      480

ggcgcccacg gcgacagcua ccccuucgac ggccccggca acacccuggc ccacgccuuc      540

gcccccggca ccggccuggg cggcgacgcc cacuucgacg aggacgagag auggaccgac      600

ggcagcagcc ugggcaucaa cuuccuguac gccgccaccc acgagcuggg ccacagccug      660

ggcaugggcc acagcagcga ccccaacgcc gugauguacc ccaccuacgg caacggcgac      720

ccccagaacu ucaagcugag ccaggacgac aucaagggca uccagaagcu guacggcaag      780

agaagcaaca gcagaaagaa guga                                             804


<210>  2770
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MMP7__Homo_sapiens__AAV40839

<400>  2770
augagacuga ccgugcucug cgccgucugu cugcuucccg gcagccuggc ucucccucug       60

ccgcaggagg ccgggggaau guccgaacuu caaugggagc aggcgcagga cuaccugaag      120

cgguucuauc ucuacgauuc ugaaacaaag aacgcuaaua gccuggaggc caagcugaaa      180

gaaaugcaga aguuuuucgg ccuccccauc acggggaugc ugaacucccg cguuauugag      240

aucaugcaaa aaccuagaug cggagugccc gacguggccg aguauucucu uuuuccuaau      300

agccccaagu ggaccuccaa ggucgugaca uaccggauug uuucuuauac ccgcgaucug      360

ccucacauca caguggacag acucgucagc aaagcucuga acaugugggg caaggaaauu      420

ccgcuucauu uccggaaagu gguuuggggg accgccgaua ucaugaucgg auuugcucgc      480

ggcgcccacg gcgacuccua ccccuucgau gggccuggaa auacacuggc gcaugccuuu      540

gcucccggca ccgggcucgg aggcgacgcc cacuucgaug aggacgaaag auggacggau      600

gggagcucuc ugggaauuaa cuuucuguau gcugccaccc augagcucgg ccacucccug      660

ggcauggggc acagcucuga cccuaaugcg gugauguacc ccacauacgg aaacggcgau      720

ccgcagaauu ucaaacuuuc ccaggacgac aucaaaggga uucagaagcu guauggaaag      780

cggagcaacu cucgcaaaaa guga                                             804


<210>  2771
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MUC-1__Homo_sapiens__AAA60019

<400>  2771

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His 
        995                 1000                1005            


Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro 
    1010                1015                1020                


Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val 
1025                1030                1035                1040


Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser 
                1045                1050                1055    


Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp 
            1060                1065                1070        


Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly 
        1075                1080                1085            


Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr 
    1090                1095                1100                


Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln 
1105                1110                1115                1120


Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile 
                1125                1130                1135    


Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser 
            1140                1145                1150        


Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys 
        1155                1160                1165            


Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys 
    1170                1175                1180                


Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg 
1185                1190                1195                1200


Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly 
                1205                1210                1215    


Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val 
            1220                1225                1230        


Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val 
        1235                1240                1245            


Ala Ala Ala Ser Ala Asn Leu 
    1250                1255


<210>  2772
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MUC-1__Homo_sapiens__J05582.1

<400>  2772
augacaccgg gcacccaguc uccuuucuuc cugcugcugc uccucacagu gcuuacaguu       60

guuacagguu cuggucaugc aagcucuacc ccagguggag aaaaggagac uucggcuacc      120

cagagaaguu cagugcccag cucuacugag aagaaugcug ugaguaugac cagcagcgua      180

cucuccagcc acagccccgg uucaggcucc uccaccacuc agggacagga ugucacucug      240

gccccggcca cggaaccagc uucagguuca gcugccaccu ggggacagga ugucaccucg      300

gucccaguca ccaggccagc ccugggcucc accaccccgc cagcccacga ugucaccuca      360

gccccggaca acaagccagc cccgggcucc accgcccccc cagcccacgg ugucaccucg      420

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      480

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      540

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      600

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      660

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      720

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      780

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      840

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      900

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg      960

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1020

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1080

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1140

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1200

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1260

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1320

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1380

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1440

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1500

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1560

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1620

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1680

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1740

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1800

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1860

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1920

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     1980

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2040

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2100

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2160

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2220

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2280

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2340

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2400

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2460

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2520

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2580

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2640

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2700

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccacgg ugucaccucg     2760

gccccggaca ccaggccggc cccgggcucc accgcccccc cagcccaugg ugucaccucg     2820

gccccggaca acaggcccgc cuugggcucc accgccccuc caguccacaa ugucaccucg     2880

gccucaggcu cugcaucagg cucagcuucu acucuggugc acaacggcac cucugccagg     2940

gcuaccacaa ccccagccag caagagcacu ccauucucaa uucccagcca ccacucugau     3000

acuccuacca cccuugccag ccauagcacc aagacugaug ccaguagcac ucaccauagc     3060

ucgguaccuc cucucaccuc cuccaaucac agcacuucuc cccaguuguc uacugggguc     3120

ucuuucuuuu uccugucuuu ucacauuuca aaccuccagu uuaauuccuc ucuggaagau     3180

cccagcaccg acuacuacca agagcugcag agagacauuu cugaaauguu uuugcagauu     3240

uauaaacaag gggguuuucu gggccucucc aauauuaagu ucaggccagg aucuguggug     3300

guacaauuga cucuggccuu ccgagaaggu accaucaaug uccacgacgu ggagacacag     3360

uucaaucagu auaaaacgga agcagccucu cgauauaacc ugacgaucuc agacgucagc     3420

gugagugaug ugccauuucc uuucucugcc cagucugggg cuggggugcc aggcuggggc     3480

aucgcgcugc uggugcuggu cuguguucug guugcgcugg ccauugucua ucucauugcc     3540

uuggcugucu gucagugccg ccgaaagaac uacgggcagc uggacaucuu uccagcccgg     3600

gauaccuacc auccuaugag cgaguacccc accuaccaca cccaugggcg cuaugugccc     3660

ccuagcagua ccgaucguag ccccuaugag aagguuucug cagguaacgg uggcagcagc     3720

cucucuuaca caaacccagc aguggcagcc gcuucugcca acuuguag                  3768


<210>  2773
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MUC-1__Homo_sapiens__J05582.1

<400>  2773
augacccccg gcacccagag cccguucuuc cugcuccugc ugcucacggu gcugaccguc       60

gugaccgggu ccggccacgc cagcuccacc cccgggggcg agaaggagac gagcgccacc      120

cagcgcucca gcgugcccuc cagcaccgag aagaacgcgg ucuccaugac cagcuccgug      180

cugagcuccc acagccccgg guccggcagc uccacgaccc agggccagga cgugacccuc      240

gccccggcca ccgagcccgc cagcgggucc gccgcgacgu ggggccagga cgucaccagc      300

gugcccguga cccggcccgc ccuggggagc accacgccgc ccgcccacga cgucaccucc      360

gcccccgaca acaagcccgc gccgggcagc accgccccgc ccgcccacgg ggugaccucc      420

gcccccgaca cgcgccccgc ccccggcagc accgcgccgc ccgcccacgg cgugaccucc      480

gcccccgaca cccggcccgc ccccgggagc acggcgcccc cggcccacgg cgucaccucc      540

gcccccgaca cccgccccgc ccccgggagc accgccccgc ccgcccacgg cgugacgucc      600

gcgcccgaca cccggccggc ccccggcagc accgccccgc ccgcccacgg ggugaccucc      660

gcccccgaca cgcgccccgc gcccggcagc accgcgcccc cggcccacgg ggucaccucc      720

gcccccgaca cccggcccgc ccccggcagc acggccccgc ccgcccacgg ggugaccucc      780

gcccccgaca cccgccccgc cccgggcagc accgcgccgc ccgcccacgg cgugaccucc      840

gcccccgaca cgcggcccgc ccccgggagc accgccccgc ccgcgcacgg cgucaccucc      900

gcccccgaca cccgccccgc ccccgggagc acggccccgc ccgcccacgg cgugaccagc      960

gcgcccgaca cccggcccgc cccggggucc accgccccgc ccgcccacgg cgugacgagc     1020

gcgcccgaca cccgccccgc ccccggcucc accgccccgc ccgcccacgg ggucaccagc     1080

gcccccgaca cgcggcccgc gcccggcucc accgcgcccc cggcccacgg ggugaccagc     1140

gcccccgaca cccgccccgc ccccggcucc acggccccgc ccgcccacgg ggugaccagc     1200

gcccccgaca cccggcccgc cccgggcucc accgccccgc ccgcgcacgg cgucacgagc     1260

gcccccgaca cccgccccgc ccccgggucc accgcgcccc cggcccacgg cgugaccagc     1320

gcccccgaca cgcggcccgc ccccgggucc accgccccgc ccgcccacgg cgucaccagc     1380

gcgcccgaca cccgccccgc cccgggcucc acggccccgc ccgcccacgg ggugaccagc     1440

gcccccgaca cccggcccgc gcccggcucc accgccccgc ccgcccacgg ggugacgagc     1500

gcccccgaca cccgccccgc ccccggcagc accgcgcccc cggcccacgg ggucaccucc     1560

gcccccgaca cgcggcccgc ccccggcagc accgccccgc ccgcgcacgg cgugaccucc     1620

gcccccgaca cccgccccgc cccggggagc accgccccgc ccgcgcacgg cgugacgucc     1680

gcccccgaca cccgccccgc ccccgggagc accgcgcccc cggcccacgg cgucaccucc     1740

gcccccgaca cgcggcccgc ccccgggagc accgccccgc ccgcccacgg cgugaccucc     1800

gcccccgaca cccgccccgc gccgggcagc acggccccgc ccgcccacgg ggugaccucc     1860

gcccccgaca cccggcccgc ccccggcagc accgcgccgc ccgcccacgg ggucacgucc     1920

gcccccgaca cccgccccgc ccccggcagc accgcgcccc cggcccacgg ggugaccucc     1980

gcccccgaca cgcggcccgc cccgggcagc accgccccgc ccgcgcacgg cgugaccucc     2040

gcccccgaca cccgccccgc ccccgggagc acggccccgc ccgcccacgg cgucaccucc     2100

gcgcccgaca cccggcccgc ccccgggagc accgcgcccc cggcccacgg cgugacgagc     2160

gcccccgaca cccgccccgc ccccgggucc accgccccgc ccgcccacgg cgugaccagc     2220

gcccccgaca cgcggcccgc gccgggcucc accgccccgc ccgcccacgg ggucaccagc     2280

gcccccgaca cccgccccgc ccccggcucc acggcgccgc ccgcccacgg ggugaccagc     2340

gcccccgaca cccggcccgc ccccggcucc accgccccgc ccgcgcacgg cgugacgagc     2400

gcccccgaca cccgccccgc cccggggucc accgccccgc ccgcccacgg cgucaccagc     2460

gcgcccgaca cccggcccgc ccccgggucc acggccccgc ccgcccacgg cgugaccagc     2520

gcccccgaca cccgccccgc gcccgggucc accgcgcccc cggcccacgg cgugacgagc     2580

gcccccgaca cccggcccgc ccccggcucc accgccccgc ccgcccacgg ggucaccagc     2640

gcccccgaca cgcgccccgc cccgggcucc accgcgccgc ccgcccacgg ggugaccagc     2700

gcccccgaca cccggcccgc ccccggcucc acggcgcccc cggcccacgg ggugaccagc     2760

gcccccgaca cccgccccgc ccccggcagc accgccccgc ccgcccacgg cgucacgucc     2820

gcgcccgaca accggcccgc ccuggggagc accgccccgc ccgugcacaa cgugaccucc     2880

gccagcggcu ccgcgagcgg guccgccagc acccucgucc acaacggcac guccgcccgc     2940

gccaccacca cccccgccag caaguccacg cccuucagca ucccguccca ccacagcgac     3000

acccccacca cccuggcguc ccacagcacg aagaccgacg ccuccagcac ccaccacucc     3060

agcgugccgc cccugaccag cuccaaccac agcacgagcc cccagcucuc caccggggug     3120

uccuucuucu uccugagcuu ccacaucucc aaccugcagu ucaacagcuc ccucgaggac     3180

cccagcaccg acuacuacca ggagcugcag cgcgacaucu ccgagauguu ccugcagauc     3240

uacaagcagg gcggcuuccu cgggcugagc aacaucaagu uccggcccgg cuccgucgug     3300

gugcagcuga cccucgccuu ccgcgagggg acgaucaacg uccacgacgu ggagacccag     3360

uucaaccagu acaagaccga ggccgccagc cgguacaacc ugaccaucuc cgacgugagc     3420

gucuccgacg ugcccuuccc guucagcgcg caguccggcg ccggcgugcc cggguggggc     3480

aucgcccugc ucguccuggu gugcgugcug gucgcccucg ccaucgugua ccugaucgcg     3540

cuggccgugu gccagugccg ccggaagaac uacgggcagc ucgacaucuu ccccgcccgc     3600

gacacguacc accccaugag cgaguacccg accuaccaca cccacggccg guacgucccg     3660

cccagcucca ccgaccgcag ccccuacgag aagguguccg ccgggaacgg cggcagcucc     3720

cugagcuaca ccaaccccgc gguggccgcc gccuccgcca accuguga                  3768


<210>  2774
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MUC-1__Homo_sapiens__J05582.1

<400>  2774
augacccccg gcacccaguc ccccuucuuc cuccuccucc uccucaccgu ccucaccguc       60

gucaccggcu ccggccacgc cuccuccacc cccggcggcg agaaggagac cuccgccacc      120

cagcgcuccu ccguccccuc cuccaccgag aagaacgccg ucuccaugac cuccuccguc      180

cucuccuccc acucccccgg cuccggcucc uccaccaccc agggccagga cgucacccuc      240

gcccccgcca ccgagcccgc cuccggcucc gccgccaccu ggggccagga cgucaccucc      300

guccccguca cccgccccgc ccucggcucc accacccccc ccgcccacga cgucaccucc      360

gcccccgaca acaagcccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      420

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      480

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      540

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      600

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      660

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      720

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      780

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      840

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      900

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc      960

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1020

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1080

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1140

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1200

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1260

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1320

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1380

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1440

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1500

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1560

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1620

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1680

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1740

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1800

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1860

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1920

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     1980

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2040

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2100

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2160

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2220

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2280

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2340

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2400

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2460

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2520

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2580

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2640

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2700

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2760

gcccccgaca cccgccccgc ccccggcucc accgcccccc ccgcccacgg cgucaccucc     2820

gcccccgaca accgccccgc ccucggcucc accgcccccc ccguccacaa cgucaccucc     2880

gccuccggcu ccgccuccgg cuccgccucc acccucgucc acaacggcac cuccgcccgc     2940

gccaccacca cccccgccuc caaguccacc cccuucucca uccccuccca ccacuccgac     3000

acccccacca cccucgccuc ccacuccacc aagaccgacg ccuccuccac ccaccacucc     3060

uccguccccc cccucaccuc cuccaaccac uccaccuccc cccagcucuc caccggcguc     3120

uccuucuucu uccucuccuu ccacaucucc aaccuccagu ucaacuccuc ccucgaggac     3180

cccuccaccg acuacuacca ggagcuccag cgcgacaucu ccgagauguu ccuccagauc     3240

uacaagcagg gcggcuuccu cggccucucc aacaucaagu uccgccccgg cuccgucguc     3300

guccagcuca cccucgccuu ccgcgagggc accaucaacg uccacgacgu cgagacccag     3360

uucaaccagu acaagaccga ggccgccucc cgcuacaacc ucaccaucuc cgacgucucc     3420

gucuccgacg uccccuuccc cuucuccgcc caguccggcg ccggcguccc cggcuggggc     3480

aucgcccucc ucguccucgu cugcguccuc gucgcccucg ccaucgucua ccucaucgcc     3540

cucgccgucu gccagugccg ccgcaagaac uacggccagc ucgacaucuu ccccgcccgc     3600

gacaccuacc accccauguc cgaguacccc accuaccaca cccacggccg cuacgucccc     3660

cccuccucca ccgaccgcuc ccccuacgag aaggucuccg ccggcaacgg cggcuccucc     3720

cucuccuaca ccaaccccgc cgucgccgcc gccuccgcca accucuga                  3768


<210>  2775
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MUC-1__Homo_sapiens__J05582.1

<400>  2775
augacccccg gcacacagag cccuuucuuu cugcuccuuc uguugacugu guuaacgguc       60

guuaccgggu ccggacacgc cucuucaaca ccagguggcg agaaggaaac cagugcuacu      120

caaagaagcu ccgugccguc uucgacagag aaaaacgcag uaucaaugac cagcagugug      180

cuguccucuc auagccccgg guccggauca aguacuacac agggccagga cgucacccua      240

gccccugcga cggaaccagc uagcgguucu gccgcaacuu gggggcagga ugugaccucc      300

guucccguga caaggccugc ccucggauca acuaccccac ccgcucacga cgucacaagc      360

gcaccugaua auaagccagc cccgggcagu accgcucccc cugcccaugg cgugacgucu      420

gcgccagaca cucggcccgc accugggucc acagccccac ccgcucacgg aguaaccagc      480

gccccggaua cucgcccugc acccgguucg acagcuccac cagcccaugg cguuaccucu      540

gcgcccgaca cgcgaccagc ccccgggucc accgcaccuc cagcucacgg agugacauca      600

gccccggaua cucgucccgc uccuggcagu accgccccac ccgcacacgg ugucacaagc      660

gccccugaca cuagaccagc ucccgggucc accgcgccgc cugcacaugg agugacaucu      720

gccccagaua ccaggcccgc uccuggcagc acugccccac cagcacacgg cgugacguca      780

gccccugaca cacggcccgc uccagggagu accgccccgc cugcacaugg agucacuucc      840

gcgcccgaua cccgcccagc ucccgguagc acagccccuc cagcacacgg cguuaccucu      900

gcccccgaca cuagaccugc uccgggguca acagccccac ccgcacacgg agugacgagu      960

gcuccugaua ccaggccagc ccccggcagc acugcgccuc cggcccaugg uguaacaucc     1020

gcucccgaca cccggccagc accugggucu acagcucccc cagcccacgg cgugacuucg     1080

gccccugaca cccgccccgc accaggaagc acggcgccgc cugcccaugg cgucaccucc     1140

gcucccgaua cacgaccagc ccccggguca acugcaccuc cagcucacgg agugaccagu     1200

gcccccgaca caagaccugc accggguucu acugccccac ccgcucaugg cguuaccagc     1260

gcgccugaua cgaggcccgc cccagggucc acagcaccuc ccgcucacgg agugaccuca     1320

gccccagaca cucggccugc cccgggcagc acagcucccc cagcacacgg ugucaccucu     1380

gccccugaua cucgucccgc gccagggucc accgcuccuc ccgcccaugg cgugacaagu     1440

gcaccggaca cgcgcccagc cccuggaagc accgcucccc cagcacacgg cguaacuucu     1500

gcccccgaua caagaccugc gccggggucc accgcucccc cagcccaugg aguuacauca     1560

gcaccugaca cuaggcccgc cccugguagu accgcuccac ccgcccacgg cgugacgagc     1620

gcaccugaua cacggccagc ucccgggucg accgccccgc cugcgcacgg agucacuucc     1680

gccccagaca cccgacccgc accuggcucu acagcuccac ccgcccaugg ugugacuagc     1740

gcuccggaua cccgcccugc acccggguca acagccccuc cugcccacgg cgucacgagu     1800

gcucccgaca ccagaccagc gcccggaucc acugcaccuc cagcccaugg cgugacaucu     1860

gcuccggaca ccaggcccgc cccugggagc acugcaccac ccgcccacgg aguuacaucc     1920

gcuccugaua cccggccagc gcccggcuca acggccccuc cggcacaugg ugugacuagc     1980

gcuccagaca cccgccccgc cccugggagu acagcacccc cagcccacgg aguaaccucu     2040

gcuccugaua cuagacccgc cccaggcucc acagcgccgc cugcacacgg ugucaccagc     2100

gcccccgaca caaggccagc ucccggcucg acugccccuc cagcucaugg ggugaccuca     2160

gcacccgaua cgcguccugc cccgggaucu acagcuccac ccgcccacgg cguuaccagu     2220

gcaccugaca cucggccagc gcccgggucc accgccccuc ccgcucaugg agugacaagc     2280

gccccagaua cucgaccggc accuggcucu accgcucccc cagcccacgg ugucacgagc     2340

gcaccugaca caagacccgc cccagggucc accgcuccuc ccgcgcaugg agugacuuca     2400

gccccggaua caaggccagc accuggcagu accgcucccc cagcccacgg uguaacuagc     2460

gcccccgaca cacgcccugc accgggcucu accgcuccac ccgcccacgg ggugacgucc     2520

gcgccugaua cucggcccgc uccaggauca accgccccuc ccgcacaugg cguuacaagu     2580

gccccagaca ccagaccugc uccggggagc acagcacccc cagcccacgg agucacuucc     2640

gcgccugaua ccaggcccgc uccaggcucu acggccccuc ccgcacaugg ugugacaucg     2700

gccccggaca cucgcccagc uccugggagc accgcacccc cagcccacgg agugacauca     2760

gcucccgaca cccgaccugc ccccggcucc acugcgcccc cugcccacgg ugucaccagu     2820

gcaccggaua accggcccgc ucugggcucu acagccccac cuguucauaa ugugacgagc     2880

gcauccgggu cagcuucugg aagcgccagu acucuugugc acaacggcac cuccgcccgu     2940

gcgacaacca cucccgcuag caaaucuaca ccauucucaa ucccuuccca ucacagugac     3000

acccccacga cucuggcaag ccauucgaca aagaccgaug ccucuuccac ccaccacagc     3060

ucaguaccgc cuuugacaag uucuaaucau uccacuagcc cacaacucuc aaccgggguc     3120

agcuuuuucu uucugaguuu ccacauuucc aaccugcagu uuaauucuag ccucgaggac     3180

cccuccacag auuacuauca ggaauuacag agagacauau cagagauguu ccugcaaauc     3240

uacaaacagg gaggcuuucu ugguuugucu aacauuaagu ucaggccugg gagugugguu     3300

gugcagcuga cucuagcuuu ucgcgaggga acgaucaaug uccaugaugu ggaaacccag     3360

uucaaccaau auaagacaga ggccgcaucg cgguacaauc ucacuauuag cgacguuucc     3420

gugucugaug uaccauuucc cuucucagcc cagagcggcg cuggcguccc ugggugggga     3480

aucgcgcugc uugugcuggu gugcgucuug guugcccucg caauagugua ucugaucgcu     3540

uuagccguau gucagugcag aaggaaaaac uacggucaac uggacauuuu cccagcacga     3600

gauaccuauc accccauguc cgaauacccg acauaccaca cccauggccg cuaugugccu     3660

cccaguucua cugaccggag cccauacgag aaggucucag ccgggaaugg aggcuccagu     3720

cucagcuaua cgaaccccgc uguggccgcg gcaucugcca aucuuuga                  3768


<210>  2776
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MUC-1__Homo_sapiens__J05582.1

<400>  2776
augacccccg gcacccagag ccccuucuuc cugcugcugc ugcugaccgu gcugaccgug       60

gugaccggca gcggccacgc cagcagcacc cccggcggcg agaaggagac cagcgccacc      120

cagagaagca gcgugcccag cagcaccgag aagaacgccg ugagcaugac cagcagcgug      180

cugagcagcc acagccccgg cagcggcagc agcaccaccc agggccagga cgugacccug      240

gcccccgcca ccgagcccgc cagcggcagc gccgccaccu ggggccagga cgugaccagc      300

gugcccguga ccagacccgc ccugggcagc accacccccc ccgcccacga cgugaccagc      360

gcccccgaca acaagcccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      420

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      480

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      540

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      600

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      660

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      720

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      780

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      840

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      900

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc      960

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1020

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1080

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1140

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1200

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1260

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1320

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1380

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1440

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1500

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1560

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1620

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1680

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1740

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1800

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1860

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1920

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     1980

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2040

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2100

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2160

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2220

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2280

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2340

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2400

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2460

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2520

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2580

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2640

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2700

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2760

gcccccgaca ccagacccgc ccccggcagc accgcccccc ccgcccacgg cgugaccagc     2820

gcccccgaca acagacccgc ccugggcagc accgcccccc ccgugcacaa cgugaccagc     2880

gccagcggca gcgccagcgg cagcgccagc acccuggugc acaacggcac cagcgccaga     2940

gccaccacca cccccgccag caagagcacc cccuucagca uccccagcca ccacagcgac     3000

acccccacca cccuggccag ccacagcacc aagaccgacg ccagcagcac ccaccacagc     3060

agcgugcccc cccugaccag cagcaaccac agcaccagcc cccagcugag caccggcgug     3120

agcuucuucu uccugagcuu ccacaucagc aaccugcagu ucaacagcag ccuggaggac     3180

cccagcaccg acuacuacca ggagcugcag agagacauca gcgagauguu ccugcagauc     3240

uacaagcagg gcggcuuccu gggccugagc aacaucaagu ucagacccgg cagcguggug     3300

gugcagcuga cccuggccuu cagagagggc accaucaacg ugcacgacgu ggagacccag     3360

uucaaccagu acaagaccga ggccgccagc agauacaacc ugaccaucag cgacgugagc     3420

gugagcgacg ugcccuuccc cuucagcgcc cagagcggcg ccggcgugcc cggcuggggc     3480

aucgcccugc uggugcuggu gugcgugcug guggcccugg ccaucgugua ccugaucgcc     3540

cuggccgugu gccagugcag aagaaagaac uacggccagc uggacaucuu ccccgccaga     3600

gacaccuacc accccaugag cgaguacccc accuaccaca cccacggcag auacgugccc     3660

cccagcagca ccgacagaag ccccuacgag aaggugagcg ccggcaacgg cggcagcagc     3720

cugagcuaca ccaaccccgc cguggccgcc gccagcgcca accuguga                  3768


<210>  2777
<211>  3768
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MUC-1__Homo_sapiens__J05582.1

<400>  2777
augacccccg gcacacagag cccuuucuuu cugcuccugc uucugacggu gcucaccguc       60

guuacagggu ccggacacgc cucuagcacc ccgggcgggg agaaggaaac auccgcuacc      120

caaagaucua gcgugcccuc cucuacagag aaaaacgccg ugagcaugac cuccagcguc      180

cugucuuccc auagcccugg aucuggcucc agcacgaccc aggggcagga cgugacacuu      240

gcgcccgcua ccgaaccugc cucuggaucc gccgcuacau ggggccagga uguuaccagc      300

gugcccguca cgcggccugc ccugggcucc acaaccccgc ccgcucacga cgugacaucu      360

gccccugaua auaagcccgc gccugggagc accgcucccc cggcccaugg aguuaccucc      420

gccccugaca cacgccccgc uccuggcagc acggccccuc ccgcgcacgg ggugaccucu      480

gcccccgaua caagaccggc ucccggaucc accgccccuc ccgcucaugg cgucacaagc      540

gccccugaca cccggcccgc cccggggucu acggcuccuc ccgcgcacgg agugacaagc      600

gccccugaua cccgccccgc uccuggcucc accgcucccc cggcccacgg cgugacaucu      660

gccccugaca ccagacccgc ccccgggagc acagcgccuc cggcucaugg agucacgucc      720

gcccccgaua cccggccugc ccccggcagc acagcuccuc ccgcccacgg gguuaccucu      780

gcuccugaca cacgccccgc cccgggaucc accgcgccuc ccgcccaugg cgugacgagc      840

gcuccugaua ccagacccgc cccggggucu acagcuccuc ccgcccacgg agugaccucc      900

gcgccugaca cacggcccgc ccccggcagc accgcuccuc cggcccacgg cgucacgucc      960

gcucccgaua cacgcccugc ccccgggucu accgccccuc ccgcucaugg agugacaagc     1020

gcgccugaca ccagaccggc ccccggcucc accgcuccuc ccgcccacgg gguuacaucu     1080

gccccugaca cgcggcccgc uccgggaagc accgccccuc ccgcgcaugg cgugacaucc     1140

gcucccgaua cccgcccugc ccccgggagc acagccccuc cggcucacgg cgucaccucu     1200

gcccccgaca cgagaccugc gcccggaucc acagcuccuc ccgcccaugg cgugaccagc     1260

gccccggaua cccggccugc ucccgggucu acagccccuc ccgcucacgg aguuaccucc     1320

gccccugaca cacgccccgc gccgggcagc acggccccuc ccgcucacgg ggugaccucu     1380

gcccccgaua caagaccugc uccgggaagc accgcucccc cugcccaugg cgucacaucc     1440

gcccccgaca cccggccugc gcccgggagc acggccccuc cggcucacgg cgugaccucu     1500

gcccccgaua caagaccugc ccccggaucc accgcuccuc ccgcccaugg cgucacaagc     1560

gcgccggaca cccgcccugc ucccgggucc acagcucccc cugcccacgg agugaccucu     1620

gcccccgaua cgcggccugc cccgggcagc acagcgcccc cugcucacgg gguuaccucc     1680

gcccccgaca ccagaccugc ccccggaucu acagcuccgc cugcccaugg cgugaccagc     1740

gcucccgaua cgcgcccugc ccccgggucc acagcgccuc ccgcccacgg cgucaccucu     1800

gcuccggaca cacggccugc ccccggaagc accgcucccc cugcccaugg cgugacaucc     1860

gccccggaca ccagacccgc uccugggagc acggcgcccc cugcccacgg aguuaccucu     1920

gcucccgaua cacgcccugc ccccggcucc accgccccgc cugcucaugg ggugacaagc     1980

gcccccgaca cccggccugc gcccggaucu acggcuccgc cugcccacgg cgucacaucc     2040

gcccccgaua ccagacccgc uccugggagc acagcgcccc cugcccacgg cgugaccucu     2100

gccccggaca cccgccccgc uccuggaucc acagcucccc cugcccaugg cgugacgagc     2160

gcccccgaua cccggccugc uccggggucc acagcgcccc cugcccacgg aguuaccagc     2220

gcccccgaca caagaccugc ucccggcucu accgccccgc cugcucaugg ggucacgagc     2280

gcccccgaua cacgccccgc cccuggaucc accgcucccc cugcgcacgg cgugaccucu     2340

gccccggaca cacggcccgc uccuggcagc accgcucccc cugcccaugg ggugacaucc     2400

gcccccgaua cgagaccggc cccuggaucu accgcgcccc cugcccacgg cgucacaagc     2460

gcucccgaca cccggccggc cccugggucc acagcuccuc ccgcccacgg agugaccucu     2520

gcgcccgaua cgcgccccgc cccuggcagc accgcuccgc ccgcccaugg gguuacaucc     2580

gcuccugaca ccagacccgc cccuggaagc acagcucccc cugcccacgg cgugaccucu     2640

gcgccggaua cacggcccgc cccuggcucc acggcucccc cugcccaugg ggucaccagc     2700

gcucccgaca caagaccggc cccuggaucu accgccccuc ccgcgcacgg cgugaccucc     2760

gcucccgaca cacgccccgc cccugggagc acggcuccgc ccgcccacgg aguuaccucc     2820

gccccugaua accggcccgc ucucggcucu acagccccuc ccgugcauaa ugucaccagc     2880

gcguccggga gcgccucugg auccgcuagc acacuggugc acaacggcac cucugccaga     2940

gcuacgacaa ccccggccag caaauccacc ccuuucucua uccccagcca ucacuccgac     3000

acaccuacca cacuggcguc ucauagcacc aagacggaug ccuccagcac acaccacucu     3060

uccguucccc cucucaccag cuccaaucau ucuacaagcc cccaacuguc caccggcgug     3120

agcuuuuucu uucuuucuuu ccacauuucc aaccugcagu uuaauagcuc ucucgaggac     3180

ccguccacgg auuacuauca ggaacugcag cgcgacauca gcgagauguu ccuucaaauu     3240

uacaaacaag ggggauuucu gggccucucu aacaucaagu ucagacccgg guccgucgug     3300

gugcagcuga cccuggcuuu ucgggaggga acaauuaaug uccaugaugu ugaaacccag     3360

uucaaccagu auaagacaga ggccgcuagc cgcuacaauc ucaccaucuc ugacgugagc     3420

guguccgaug ucccuuuucc cuucucugcc cagagcggcg cuggggugcc uggauggggc     3480

aucgcccugc uuguucuggu gugcguccuc guggcgcugg ccauuguuua ucuuaucgcu     3540

cuggccgugu gucagugcag acggaaaaac uacggccaac ucgacauuuu cccggcucgc     3600

gauacauauc accccauguc cgaauacccu accuaccaca cgcaugggag auaugugccc     3660

ccuagcucca cagaccgguc ucccuacgag aaggucagcg ccggaaaugg cggguccucu     3720

cugagcuaua ccaacccugc cguugcggcu gccuccgcca aucuguga                  3768


<210>  2778
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MUM-1/m__Homo_sapiens__NP_116242

<400>  2778

Met Met Ala Asp Ala Lys Tyr Val Leu Cys Arg Trp Glu Lys Arg Leu 
1               5                   10                  15      


Trp Pro Ala Lys Val Leu Ala Arg Thr Ala Thr Ser Thr Lys Asn Lys 
            20                  25                  30          


Arg Arg Lys Glu Tyr Phe Leu Ala Val Gln Ile Leu Ser Leu Glu Glu 
        35                  40                  45              


Lys Ile Lys Val Lys Ser Thr Glu Val Glu Ile Leu Glu Lys Ser Gln 
    50                  55                  60                  


Ile Glu Ala Ile Ala Ser Ser Leu Ala Ser Gln Asn Glu Val Pro Ala 
65                  70                  75                  80  


Ala Pro Leu Glu Glu Leu Ala Tyr Arg Arg Ser Leu Arg Val Ala Leu 
                85                  90                  95      


Asp Val Leu Ser Glu Gly Ser Ile Trp Ser Gln Glu Ser Ser Ala Gly 
            100                 105                 110         


Thr Gly Arg Ala Asp Arg Ser Leu Arg Gly Lys Pro Met Glu His Val 
        115                 120                 125             


Ser Ser Pro Cys Asp Ser Asn Ser Ser Ser Leu Pro Arg Gly Asp Val 
    130                 135                 140                 


Leu Gly Ser Ser Arg Pro His Arg Arg Arg Pro Cys Val Gln Gln Ser 
145                 150                 155                 160 


Leu Ser Ser Ser Phe Thr Cys Glu Lys Asp Pro Glu Cys Lys Val Asp 
                165                 170                 175     


His Lys Lys Gly Leu Arg Lys Ser Glu Asn Pro Arg Gly Pro Leu Val 
            180                 185                 190         


Leu Pro Ala Gly Gly Gly Ala Gln Asp Glu Ser Gly Ser Arg Ile His 
        195                 200                 205             


His Lys Asn Trp Thr Leu Ala Ser Lys Arg Gly Gly Asn Ser Ala Gln 
    210                 215                 220                 


Lys Ala Ser Leu Cys Leu Asn Gly Ser Ser Leu Ser Glu Asp Asp Thr 
225                 230                 235                 240 


Glu Arg Asp Met Gly Ser Lys Gly Gly Ser Trp Ala Ala Pro Ser Leu 
                245                 250                 255     


Pro Ser Gly Val Arg Glu Asp Asp Pro Cys Ala Asn Ala Glu Gly His 
            260                 265                 270         


Asp Pro Gly Leu Pro Leu Gly Ser Leu Thr Ala Pro Pro Ala Pro Glu 
        275                 280                 285             


Pro Ser Ala Cys Ser Glu Pro Gly Glu Cys Pro Ala Lys Lys Arg Pro 
    290                 295                 300                 


Arg Leu Asp Gly Ser Gln Arg Pro Pro Ala Val Gln Leu Glu Pro Met 
305                 310                 315                 320 


Ala Ala Gly Ala Ala Pro Ser Pro Gly Pro Gly Pro Gly Pro Arg Glu 
                325                 330                 335     


Ser Val Thr Pro Arg Ser Thr Ala Arg Leu Gly Pro Pro Pro Ser His 
            340                 345                 350         


Ala Ser Ala Asp Ala Thr Arg Cys Leu Pro Cys Pro Asp Ser Gln Lys 
        355                 360                 365             


Leu Glu Lys Glu Cys Gln Ser Ser Glu Glu Ser Met Gly Ser Asn Ser 
    370                 375                 380                 


Met Arg Ser Ile Leu Glu Glu Asp Glu Glu Asp Glu Glu Pro Pro Arg 
385                 390                 395                 400 


Val Leu Leu Tyr His Glu Pro Arg Ser Phe Glu Val Gly Met Leu Val 
                405                 410                 415     


Trp His Lys His Lys Lys Tyr Pro Phe Trp Pro Ala Val Val Lys Ser 
            420                 425                 430         


Val Arg Gln Arg Asp Lys Lys Ala Ser Val Leu Tyr Ile Glu Gly His 
        435                 440                 445             


Met Asn Pro Lys Met Lys Gly Phe Thr Val Ser Leu Lys Ser Leu Lys 
    450                 455                 460                 


His Phe Asp Cys Lys Glu Lys Gln Thr Leu Leu Asn Gln Ala Arg Glu 
465                 470                 475                 480 


Asp Phe Asn Gln Asp Ile Gly Trp Cys Val Ser Leu Ile Thr Asp Tyr 
                485                 490                 495     


Arg Val Arg Leu Gly Cys Gly Ser Phe Ala Gly Ser Phe Leu Glu Tyr 
            500                 505                 510         


Tyr Ala Ala Asp Ile Ser Tyr Pro Val Arg Lys Ser Ile Gln Gln Asp 
        515                 520                 525             


Val Leu Gly Thr Lys Leu Pro Gln Leu Ser Lys Gly Ser Pro Glu Glu 
    530                 535                 540                 


Pro Val Val Gly Cys Pro Leu Gly Gln Arg Gln Pro Cys Arg Lys Met 
545                 550                 555                 560 


Leu Pro Asp Arg Ser Arg Ala Ala Arg Asp Arg Ala Asn Gln Lys Leu 
                565                 570                 575     


Val Glu Tyr Ile Val Lys Ala Lys Gly Ala Glu Ser His Leu Arg Ala 
            580                 585                 590         


Ile Leu Lys Ser Arg Lys Pro Ser Arg Trp Leu Gln Thr Phe Leu Ser 
        595                 600                 605             


Ser Ser Gln Tyr Val Thr Cys Val Glu Thr Tyr Leu Glu Asp Glu Gly 
    610                 615                 620                 


Gln Leu Asp Leu Val Val Lys Tyr Leu Gln Gly Val Tyr Gln Glu Val 
625                 630                 635                 640 


Gly Ala Lys Val Leu Gln Arg Thr Asn Gly Asp Arg Ile Arg Phe Ile 
                645                 650                 655     


Leu Asp Val Leu Leu Pro Glu Ala Ile Ile Cys Ala Ile Ser Ala Val 
            660                 665                 670         


Asp Glu Val Asp Tyr Lys Thr Ala Glu Glu Lys Tyr Ile Lys Gly Pro 
        675                 680                 685             


Ser Leu Ser Tyr Arg Glu Lys Glu Ile Phe Asp Asn Gln Leu Leu Glu 
    690                 695                 700                 


Glu Arg Asn Arg Arg Arg Arg 
705                 710     


<210>  2779
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MUM-1/m__Homo_sapiens__NM_032853

<400>  2779
augauggcgg augccaagua uguccucugc cgaugggaaa agcgauuaug gccugcgaag       60

guuuuggccc gaaccgcgac uucaacaaaa aauaagagaa gaaaggaaua uuuucuagcu      120

gugcaaaucc ucucucuaga ggaaaaaauu aaggugaaaa gcacugaagu ugagauccua      180

gagaagucuc aaauugaagc cauugcuucc ucguuagccu cacagaauga gguuccugcg      240

gcaccccugg aagaacuggc cuacagacgg ucgcuucgcg uggcucugga cguucugagc      300

gagggcucga uuuggaguca agaaagcucu gcagggacag guagagcuga ccggucucug      360

cgagggaagc ccauggagca ugucuccucg cccugugauu cgaacuccuc aucucuuccc      420

cgcggagacg uguugggcag uuccagaccu cacaggagga ggccaugugu gcaacaaagc      480

cugucaaguu cguucacuug ugaaaaggac cccgagugca aaguggacca caagaagggg      540

cucaggaaaa gugaaaaccc aagaggcccg uugguccucc cagcuggagg uggugcccaa      600

gaugagagug gguccagaau ccaccacaaa aauuggacuc uugcaaguaa gaggggagga      660

aacucagcgc agaaggcuag cuugugccug aauggaucuu cccuuucaga ggacgacacg      720

gagagagaca uggggagcaa aggaggcagc ugggcagccc cguccuugcc cuccgggguc      780

agggaggacg aucccugugc caacgcugag ggacacgacc ccggucugcc guugggcagc      840

cucacugcgc ccccagcccc ugagcccucg gccugcucag agccuggaga augcccugcg      900

aaaaagaggc cgcgccugga uggcagccaa aggccgccug ccgugcagcu ggagcccaug      960

gcagcagggg ccgcaccauc ccccgggccg gggccagggc ccagagaguc ugugaccccg     1020

cgcagcaccg ccaggcuggg cccgccuccc ucccacgccu cugcggaugc aaccagaugu     1080

cuuccuugcc cggauuccca gaagcuggag aaagagugcc agucuuccga agaguccaug     1140

gggucuaauu ccaugcguuc uauccuggag gaagacgagg aagacgagga gccaccaaga     1200

guccuuuuau accacgaacc acguucguuu gaaguaggaa ugcuagucug gcauaaacau     1260

aaaaaauacc ccuucuggcc agcagugguc aaaagcguca ggcagagaga uaagaaagca     1320

agugugcuau acaucgaagg acacaugaac ccgaaaauga aagguuucac agugucucuu     1380

aaaaguuuaa agcacuuuga uuguaaagag aaacagacgc uucugaauca agccagggag     1440

gacuucaacc aggacaucgg cugguguguc ucccucauca ccgacuacag gguccgguua     1500

ggcugcgggu cuuuugcugg cucuuuccug gaauauuacg cggcugauau aagcuauccu     1560

guccgaaaau ccauccagca ggacgucuug gggaccaagc uuccucaacu gagcaagggg     1620

agccccgagg agcccguggu ggggugcccc cuggggcaga ggcagcccug ccggaaaaug     1680

cuccccgacc gcucgcgggc cgcccgggac cgggccaacc agaagcuggu ggaguacauu     1740

gugaaggcca agggcgcgga gagccaccug cgggccaucc uaaagagcag gaagccaucu     1800

cgcuggcugc agaccuuccu gagcuccagc caguacguga ccugugugga gaccuaccug     1860

gaggaugagg ggcagcugga ccugguggug aaguaccugc agggcgucua ccaggaggug     1920

ggggccaagg ugcuccagcg caccaacggc gaccggaucc gguucauucu ggacgugcuu     1980

cugcccgagg ccaucaucug ugcgaucucu gcgguggacg agguggacua caagacggcu     2040

gaggagaagu acaucaaggg gccuucgcug agcuaccggg aaaaagaaau auuugacaac     2100

cagcuccuug aagagcggaa ccggcgccgu cgguga                               2136


<210>  2780
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MUM-1/m__Homo_sapiens__NM_032853

<400>  2780
augauggccg acgccaagua cgugcugugc cgcugggaga agcggcucug gcccgcgaag       60

guccuggccc gcaccgccac cagcacgaag aacaagcggc gcaaggagua cuuccuggcc      120

gugcagaucc ucucccugga ggagaagauc aaggucaaga gcaccgaggu ggagauccug      180

gagaaguccc agaucgaggc caucgcgagc ucccucgcca gccagaacga ggugccggcc      240

gcgccccugg aggagcuggc cuaccggcgc ucccuccggg uggcccugga cguccugagc      300

gagggcucca ucuggagcca ggaguccagc gccgggaccg gccgcgccga ccggucccuc      360

cgcgggaagc ccauggagca cgugagcucc cccugcgaca gcaacuccag cucccugccg      420

cggggcgacg ugcuggggag cagccgcccc caccggcgcc ggcccugcgu ccagcagucc      480

cucagcucca gcuucacgug cgagaaggac cccgagugca agguggacca caagaagggc      540

cugcgcaagu ccgagaaccc gcggggcccc cuggugcucc ccgccggggg cggggcgcag      600

gacgagagcg gcucccgcau ccaccacaag aacuggaccc uggccagcaa gcggggcggc      660

aacuccgccc agaaggccag ccugugccuc aacggcucca gccuguccga ggacgacacc      720

gagcgcgaca uggggagcaa gggcgggucc ugggccgcgc ccagccugcc guccggcguc      780

cgggaggacg accccugcgc caacgccgag ggccacgacc ccgggcuccc ccugggcagc      840

cugaccgccc cgcccgcccc cgagcccucc gcgugcagcg agccggggga gugccccgcc      900

aagaagcgcc cccgccucga cggcagccag cggcccccgg ccgugcagcu ggagcccaug      960

gccgccgggg cggcccccuc ccccggcccg ggccccgggc cccgcgagag cgugaccccg     1020

cgguccacgg cccgccuggg gcccccgccc agccacgccu ccgcggacgc cacccggugc     1080

cuccccugcc ccgacagcca gaagcuggag aaggagugcc aguccagcga ggaguccaug     1140

gggagcaacu ccaugcgcag cauccuggag gaggacgagg aggacgagga gccgccccgg     1200

guccuccugu accacgagcc ccgcuccuuc gaggugggca ugcuggugug gcacaagcac     1260

aagaaguacc ccuucuggcc cgccgucguc aagagcgugc ggcagcgcga caagaaggcc     1320

uccgugcucu acaucgaggg gcacaugaac cccaagauga agggcuucac cgugagccug     1380

aagucccuga agcacuucga cugcaaggag aagcagaccc uccugaacca ggcccgggag     1440

gacuucaacc aggacaucgg cuggugcgug agccugauca cggacuaccg cguccggcuc     1500

gggugcggca gcuucgcggg guccuuccug gaguacuacg ccgccgacau cagcuacccg     1560

gugcgcaagu ccauccagca ggacguccug ggcaccaagc ucccccagcu gagcaagggg     1620

ucccccgagg agcccguggu gggcugcccg cugggccagc ggcagcccug ccgcaagaug     1680

cuccccgacc ggagccgcgc cgcccgggac cgcgcgaacc agaagcuggu cgaguacauc     1740

gugaaggcca agggggccga gucccaccuc cgcgccaucc ucaagagccg gaagcccucc     1800

cgcuggcugc agaccuuccu gagcuccagc caguacguga ccugcgucga gacguaccug     1860

gaggacgagg gccagcugga ccugguggug aaguaccugc agggggucua ccaggaggug     1920

ggcgccaagg ugcuccagcg gaccaacggc gaccgcaucc gguucauccu ggacguccug     1980

cucccggagg cgaucaucug cgccaucucc gccguggacg agguggacua caagaccgcc     2040

gaggagaagu acaucaaggg gcccagccug uccuaccgcg agaaggagau cuucgacaac     2100

cagcugcucg aggagcggaa ccgccggcgc cgguga                               2136


<210>  2781
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MUM-1/m__Homo_sapiens__NM_032853

<400>  2781
augauggccg acgccaagua cguccucugc cgcugggaga agcgccucug gcccgccaag       60

guccucgccc gcaccgccac cuccaccaag aacaagcgcc gcaaggagua cuuccucgcc      120

guccagaucc ucucccucga ggagaagauc aaggucaagu ccaccgaggu cgagauccuc      180

gagaaguccc agaucgaggc caucgccucc ucccucgccu cccagaacga gguccccgcc      240

gccccccucg aggagcucgc cuaccgccgc ucccuccgcg ucgcccucga cguccucucc      300

gagggcucca ucugguccca ggaguccucc gccggcaccg gccgcgccga ccgcucccuc      360

cgcggcaagc ccauggagca cgucuccucc cccugcgacu ccaacuccuc cucccucccc      420

cgcggcgacg uccucggcuc cucccgcccc caccgccgcc gccccugcgu ccagcagucc      480

cucuccuccu ccuucaccug cgagaaggac cccgagugca aggucgacca caagaagggc      540

cuccgcaagu ccgagaaccc ccgcggcccc cucguccucc ccgccggcgg cggcgcccag      600

gacgaguccg gcucccgcau ccaccacaag aacuggaccc ucgccuccaa gcgcggcggc      660

aacuccgccc agaaggccuc ccucugccuc aacggcuccu cccucuccga ggacgacacc      720

gagcgcgaca ugggcuccaa gggcggcucc ugggccgccc ccucccuccc cuccggcguc      780

cgcgaggacg accccugcgc caacgccgag ggccacgacc ccggccuccc ccucggcucc      840

cucaccgccc cccccgcccc cgagcccucc gccugcuccg agcccggcga gugccccgcc      900

aagaagcgcc cccgccucga cggcucccag cgcccccccg ccguccagcu cgagcccaug      960

gccgccggcg ccgcccccuc ccccggcccc ggccccggcc cccgcgaguc cgucaccccc     1020

cgcuccaccg cccgccucgg cccccccccc ucccacgccu ccgccgacgc cacccgcugc     1080

cuccccugcc ccgacuccca gaagcucgag aaggagugcc aguccuccga ggaguccaug     1140

ggcuccaacu ccaugcgcuc cauccucgag gaggacgagg aggacgagga gcccccccgc     1200

guccuccucu accacgagcc ccgcuccuuc gaggucggca ugcucgucug gcacaagcac     1260

aagaaguacc ccuucuggcc cgccgucguc aaguccgucc gccagcgcga caagaaggcc     1320

uccguccucu acaucgaggg ccacaugaac cccaagauga agggcuucac cgucucccuc     1380

aagucccuca agcacuucga cugcaaggag aagcagaccc uccucaacca ggcccgcgag     1440

gacuucaacc aggacaucgg cuggugcguc ucccucauca ccgacuaccg cguccgccuc     1500

ggcugcggcu ccuucgccgg cuccuuccuc gaguacuacg ccgccgacau cuccuacccc     1560

guccgcaagu ccauccagca ggacguccuc ggcaccaagc ucccccagcu cuccaagggc     1620

ucccccgagg agcccgucgu cggcugcccc cucggccagc gccagcccug ccgcaagaug     1680

cuccccgacc gcucccgcgc cgcccgcgac cgcgccaacc agaagcucgu cgaguacauc     1740

gucaaggcca agggcgccga gucccaccuc cgcgccaucc ucaagucccg caagcccucc     1800

cgcuggcucc agaccuuccu cuccuccucc caguacguca ccugcgucga gaccuaccuc     1860

gaggacgagg gccagcucga ccucgucguc aaguaccucc agggcgucua ccaggagguc     1920

ggcgccaagg uccuccagcg caccaacggc gaccgcaucc gcuucauccu cgacguccuc     1980

cuccccgagg ccaucaucug cgccaucucc gccgucgacg aggucgacua caagaccgcc     2040

gaggagaagu acaucaaggg ccccucccuc uccuaccgcg agaaggagau cuucgacaac     2100

cagcuccucg aggagcgcaa ccgccgccgc cgcuga                               2136


<210>  2782
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MUM-1/m__Homo_sapiens__NM_032853

<400>  2782
augauggccg acgcuaagua cgugcugugc agaugggaga aaaggcucug gcccgcaaag       60

guccuugccc ggaccgcgac aagcacuaaa aacaagcgcc gaaaagaaua uuuccuggcu      120

guucagaucu uguccuuaga ggaaaagauu aaggugaaau cuacggaggu agaaauacug      180

gagaagucac aaaucgaggc cauugcaagu agccuagccu cccagaauga agugccugcu      240

gcaccacucg aggaacuggc cuaccguaga ucucuuaggg ucgcucugga uguguugucg      300

gagggcucaa ucuggagcca ggagaguucc gccgggaccg gacgggcgga ccgcucucuc      360

agagguaaac cgauggaaca cguuagcucc cccugugauu caaacaguag cucucugccu      420

aggggcgacg ugcugggguc cucacggcca caucgccgaa gacccugcgu ccagcaaagc      480

cucaguucuu ccuuuacaug ugagaaggau ccugaaugca aaguggacca caagaaggga      540

uuaaggaaaa gcgagaaucc acggggcccc cugguacuuc cugccggugg gggagcacag      600

gaugaaucgg gcucucguau ucaucacaag aacuggacuu uggcuuccaa acgcggcggg      660

aauagcgccc agaaggcaag ucugugucua aacggaagcu cccucucuga ggacgauacc      720

gagagagaca uggguagcaa aggcggguca ugggcugccc caagucugcc guccggaguu      780

agggaagaug accccugcgc gaaugccgag ggccaugauc cuggucuucc acuggggagc      840

uugacagcac ccccugcucc agaacccucu gccuguucag agccgggaga augcccugcu      900

aagaaacggc cccgacucga cggcagucag cgcccuccag ccgugcaacu ggagcccaug      960

gcagccggcg cugcgccaag ccccgggccu ggaccagguc cgagagaguc cgucaccccc     1020

aggucuacug cacgguuagg cccuccaccc ucgcacgcca gcgcugacgc cacacgcugu     1080

cugccuugcc cagauuccca gaagcucgaa aaggaguguc agucaaguga agagucuaug     1140

gggagcaacu ccaugagauc aauccuugaa gaggacgagg aagaugagga acccccgagg     1200

gugcuguugu aucacgagcc ucguagcuuc gaggugggaa ugcuagucug gcauaaacac     1260

aagaaauacc cauuuuggcc cgcaguugug aagucuguac ggcagcgaga caaaaaggcc     1320

uccgugcugu auauagaagg ccauaugaau ccuaagauga aagguuucac cgucagucuc     1380

aagagccuga aacacuuuga uugcaaggag aaacaaacgc uucugaacca ggcuagagaa     1440

gacuucaauc aggauaucgg guggugcgug ucuuugauua cugacuacag gguucgccuc     1500

ggcuguggau ccuuugccgg cucauuccug gaguauuacg cagcggauau caguuacccc     1560

gugcggaagu caauucaaca ggacgucuua gggaccaagc ugccacagcu aucgaaagga     1620

uccccugaag aacccguggu agguugccca cucggccaga gacaaccgug uaggaagaug     1680

cugccugauc gcucucgagc ugcccgggac cgugcaaacc agaaacuugu ugaguauauc     1740

gugaaggcca aaggggcuga aagccacuug agagccauac ugaagucaag gaagcccagu     1800

cgcuggcucc agacauuucu guccucuagc caguacguca cuugcgugga gaccuaucuu     1860

gaagacgagg gacaacugga uuuggucgug aaauaccucc agggcguuua ucaggaagug     1920

ggugcaaagg uacugcagcg gacaaauggg gacagaauua gguucaucuu agauguccug     1980

cuaccagagg cuauuaucug ugccaucucc gcgguggacg agguugauua caaaaccgcc     2040

gaagagaagu auauuaaagg ccccucacuc agcuaccgag aaaaggagau auuugacaac     2100

caacugcuug aggagcgcaa ucggagaagg cguuga                               2136


<210>  2783
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MUM-1/m__Homo_sapiens__NM_032853

<400>  2783
augauggccg acgccaagua cgugcugugc agaugggaga agagacugug gcccgccaag       60

gugcuggcca gaaccgccac cagcaccaag aacaagagaa gaaaggagua cuuccuggcc      120

gugcagaucc ugagccugga ggagaagauc aaggugaaga gcaccgaggu ggagauccug      180

gagaagagcc agaucgaggc caucgccagc agccuggcca gccagaacga ggugcccgcc      240

gccccccugg aggagcuggc cuacagaaga agccugagag uggcccugga cgugcugagc      300

gagggcagca ucuggagcca ggagagcagc gccggcaccg gcagagccga cagaagccug      360

agaggcaagc ccauggagca cgugagcagc cccugcgaca gcaacagcag cagccugccc      420

agaggcgacg ugcugggcag cagcagaccc cacagaagaa gacccugcgu gcagcagagc      480

cugagcagca gcuucaccug cgagaaggac cccgagugca agguggacca caagaagggc      540

cugagaaaga gcgagaaccc cagaggcccc cuggugcugc ccgccggcgg cggcgcccag      600

gacgagagcg gcagcagaau ccaccacaag aacuggaccc uggccagcaa gagaggcggc      660

aacagcgccc agaaggccag ccugugccug aacggcagca gccugagcga ggacgacacc      720

gagagagaca ugggcagcaa gggcggcagc ugggccgccc ccagccugcc cagcggcgug      780

agagaggacg accccugcgc caacgccgag ggccacgacc ccggccugcc ccugggcagc      840

cugaccgccc cccccgcccc cgagcccagc gccugcagcg agcccggcga gugccccgcc      900

aagaagagac ccagacugga cggcagccag agaccccccg ccgugcagcu ggagcccaug      960

gccgccggcg ccgcccccag ccccggcccc ggccccggcc ccagagagag cgugaccccc     1020

agaagcaccg ccagacuggg cccccccccc agccacgcca gcgccgacgc caccagaugc     1080

cugcccugcc ccgacagcca gaagcuggag aaggagugcc agagcagcga ggagagcaug     1140

ggcagcaaca gcaugagaag cauccuggag gaggacgagg aggacgagga gccccccaga     1200

gugcugcugu accacgagcc cagaagcuuc gaggugggca ugcuggugug gcacaagcac     1260

aagaaguacc ccuucuggcc cgccguggug aagagcguga gacagagaga caagaaggcc     1320

agcgugcugu acaucgaggg ccacaugaac cccaagauga agggcuucac cgugagccug     1380

aagagccuga agcacuucga cugcaaggag aagcagaccc ugcugaacca ggccagagag     1440

gacuucaacc aggacaucgg cuggugcgug agccugauca ccgacuacag agugagacug     1500

ggcugcggca gcuucgccgg cagcuuccug gaguacuacg ccgccgacau cagcuacccc     1560

gugagaaaga gcauccagca ggacgugcug ggcaccaagc ugccccagcu gagcaagggc     1620

agccccgagg agcccguggu gggcugcccc cugggccaga gacagcccug cagaaagaug     1680

cugcccgaca gaagcagagc cgccagagac agagccaacc agaagcuggu ggaguacauc     1740

gugaaggcca agggcgccga gagccaccug agagccaucc ugaagagcag aaagcccagc     1800

agauggcugc agaccuuccu gagcagcagc caguacguga ccugcgugga gaccuaccug     1860

gaggacgagg gccagcugga ccugguggug aaguaccugc agggcgugua ccaggaggug     1920

ggcgccaagg ugcugcagag aaccaacggc gacagaauca gauucauccu ggacgugcug     1980

cugcccgagg ccaucaucug cgccaucagc gccguggacg agguggacua caagaccgcc     2040

gaggagaagu acaucaaggg ccccagccug agcuacagag agaaggagau cuucgacaac     2100

cagcugcugg aggagagaaa cagaagaaga agauga                               2136


<210>  2784
<211>  2136
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MUM-1/m__Homo_sapiens__NM_032853

<400>  2784
augauggccg acgcuaagua cgugcugugc agaugggaga aacggcucug gcccgccaag       60

guccuggcgc gcaccgcuac aagcacgaaa aacaagagac ggaaagaaua uuuccuugcc      120

guucagaucc ugucccucga ggaaaagauu aaggugaaau cuaccgaggu ggaaauccug      180

gaaaagagcc aaauugaggc caucgcuucc ucucuugcca gccagaauga agucccugcu      240

gccccgcugg aggaacucgc guaccgcaga ucccugcggg uggcccugga uguucucucu      300

gagggcagca uuugguccca ggagagcucu gcugggacag gacgcgccga cagaucccug      360

cggggcaaac ccauggaaca cgugagcucu ccuugugauu ccaacucuag cucccuuccc      420

cgcggggacg uccugggaag cuccagaccu caccggcgca gacccugcgu gcagcaaucu      480

cucagcucca gcuuuaccug ugagaaggau ccugaaugca aaguugacca caagaagggc      540

cugcggaaau cugagaaucc gcgcgggccc cuugugcugc cugcuggagg cggcgcccag      600

gaugaauccg ggagcagaau ccaucacaag aacuggacac ucgcgucuaa acggggaggc      660

aauagcgccc agaaggcuuc ccugugucug aacgggucua gccucuccga ggacgauacc      720

gagagagaca ugggaagcaa aggcgggucu ugggccgcuc ccucccugcc uagcggaguc      780

cgcgaagaug accccugcgc caaugccgag ggccaugauc cgggccuucc ucuggggucu      840

cucacagcuc ccccugcgcc cgaacccucc gccuguagcg agccuggaga augcccggcu      900

aagaaacggc ccagacugga cggcucccag cgcccucccg ccgugcaacu ugagccuaug      960

gccgcugggg ccgcgcccuc uccgggaccu ggccccgggc cucgggagag cgugaccccc     1020

agauccacgg cucgccuggg accucccccg ucucacgcca gcgccgacgc uacccggugu     1080

cucccuugcc ccgauuccca gaagcuggaa aaggaguguc agagcucuga agaguccaug     1140

ggcagcaacu cuaugagauc cauccuggaa gaggacgagg aagaugagga acccccucgc     1200

guccuccugu aucacgagcc gcggagcuuc gagguuggca ugcuugugug gcauaaacac     1260

aagaaauacc ccuuuuggcc ugccgugguc aagucuguga gacagcgcga caaaaaggcu     1320

agcguucugu auauugaagg gcauaugaau cccaagauga aaggauucac agugucccuc     1380

aagagccuga aacacuuuga uugcaaggag aaacaaaccc uucugaacca ggcccgggaa     1440

gacuucaauc aggauaucgg cuggugcguc ucucucauua cagacuacag agugcggcug     1500

ggguguggau ccuuugcggg cagcuuccug gaguauuacg ccgcugauau cuccuacccu     1560

guucgcaagu cuauucaaca ggacgugcuc gggaccaagc ugccccagcu uagcaaaggc     1620

uccccugagg agcccgucgu gggaugcccg cugggccaga gacaaccuug ucggaagaug     1680

cuccccgaua gaucucgcgc cgcucgggac agagccaacc agaaacuggu cgaguauauc     1740

gugaaggcga aaggggccga aagccaucug cgcgcuauuc uuaaguccag aaagccuucu     1800

cgguggcucc agacguuucu gagcuccagc caguacguua caugcgugga gaccuaucug     1860

gaagacgagg gacaacucga ucuggucgug aaauaccuuc agggcguuua ucaggaagug     1920

ggggccaagg uccugcagcg cacaaaugga gacagaaucc gguucauccu cgaugugcug     1980

cugcccgagg cuauuaucug ugccauuucu gccguggacg agguugauua caaaaccgcu     2040

gaagagaagu auaucaaagg cccgucccuu agcuaccgcg aaaaggagau uuuugacaac     2100

caacuccugg aagagagaaa ucggcgcaga cgguga                               2136


<210>  2785
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MUM-2/m__Homo_sapiens__Q9Y5R8

<400>  2785

Met Thr Val His Asn Leu Tyr Leu Phe Asp Arg Asn Gly Val Cys Leu 
1               5                   10                  15      


His Tyr Ser Glu Trp His Arg Lys Lys Gln Ala Gly Ile Pro Lys Glu 
            20                  25                  30          


Glu Glu Tyr Lys Leu Met Tyr Gly Met Leu Phe Ser Ile Arg Ser Phe 
        35                  40                  45              


Val Ser Lys Met Ser Pro Leu Asp Met Lys Asp Gly Phe Leu Ala Phe 
    50                  55                  60                  


Gln Thr Ser Arg Tyr Lys Leu His Tyr Tyr Glu Thr Pro Thr Gly Ile 
65                  70                  75                  80  


Lys Val Val Met Asn Thr Asp Leu Gly Val Gly Pro Ile Arg Asp Val 
                85                  90                  95      


Leu His His Ile Tyr Ser Ala Leu Tyr Val Glu Leu Val Val Lys Asn 
            100                 105                 110         


Pro Leu Cys Pro Leu Gly Gln Thr Val Gln Ser Glu Leu Phe Arg Ser 
        115                 120                 125             


Arg Leu Asp Ser Tyr Val Arg Ser Leu Pro Phe Phe Ser Ala Arg Ala 
    130                 135                 140                 


Gly 
145 


<210>  2786
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MUM-2/m__Homo_sapiens__AAD44697

<400>  2786
augacugucc acaaccugua ccuguuugac cggaauggag ugugucugca cuacagcgaa       60

uggcaccgca agaagcaagc agggauuccc aaggaggagg aguauaagcu gauguacggg      120

augcucuucu cuauccgcuc guuugucagc aagauguccc cgcuagacau gaaggauggc      180

uuccuggccu uccaaacuag ccguuacaaa cuccauuacu acgagacgcc cacugggauc      240

aaaguuguca ugaauacuga cuugggcgug ggacccaucc gagaugugcu gcaccacauc      300

uacagugcgc uguaugugga gcugguggug aagaaucccc ugugcccgcu gggccaaacu      360

gugcaaagug agcucuuucg cucccgacug gacuccuaug uucgcucucu gcccuucuuc      420

uccgcccggg cuggcuga                                                    438


<210>  2787
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MUM-2/m__Homo_sapiens__AAD44697

<400>  2787
augaccgugc acaaccugua ccucuucgac cgcaacggcg ucugccugca cuacagcgag       60

uggcaccgga agaagcaggc cgggaucccc aaggaggagg aguacaagcu gauguacggc      120

augcuguucu ccauccgcag cuucgugucc aagaugagcc cgcucgacau gaaggacggg      180

uuccuggccu uccagaccuc ccgguacaag cuccacuacu acgagacgcc caccggcauc      240

aaggugguca ugaacaccga ccugggggug ggccccaucc gcgacgugcu gcaccacauc      300

uacagcgcgc ucuacgucga gcugguggug aagaaccccc ugugcccgcu cggccagacc      360

guccaguccg agcuguuccg gagccgccug gacuccuacg ugcggagccu ccccuucuuc      420

uccgcccgcg ccggguga                                                    438


<210>  2788
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MUM-2/m__Homo_sapiens__AAD44697

<400>  2788
augaccgucc acaaccucua ccucuucgac cgcaacggcg ucugccucca cuacuccgag       60

uggcaccgca agaagcaggc cggcaucccc aaggaggagg aguacaagcu cauguacggc      120

augcucuucu ccauccgcuc cuucgucucc aagauguccc cccucgacau gaaggacggc      180

uuccucgccu uccagaccuc ccgcuacaag cuccacuacu acgagacccc caccggcauc      240

aaggucguca ugaacaccga ccucggcguc ggccccaucc gcgacguccu ccaccacauc      300

uacuccgccc ucuacgucga gcucgucguc aagaaccccc ucugcccccu cggccagacc      360

guccaguccg agcucuuccg cucccgccuc gacuccuacg uccgcucccu ccccuucuuc      420

uccgcccgcg ccggcuga                                                    438


<210>  2789
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MUM-2/m__Homo_sapiens__AAD44697

<400>  2789
augaccgugc acaaccugua ccucuucgac agaaauggcg ucugccuuca uuauagcgag       60

uggcacagga agaaacaggc cgggaucccc aaggaagagg aauacaaacu gauguaugga      120

auguuguuuu ccauucgguc uuucguuuca aagaugaguc cuuuagauau gaaagacggu      180

uuucuggcuu uccaaacaag ccgcuacaag cuacauuauu acgagacucc aacgggcaua      240

aaggugguaa ugaacaccga ucucggggug ggaccgaucc gagacguccu gcaccauauu      300

uauuccgcac uuuacgugga acugguugug aaaaaucccu uguguccucu cggccagaca      360

guccagucug agcuguuucg uucgagacug gauucauacg ugaggagccu cccauucuuu      420

agugcccggg cggguuga                                                    438


<210>  2790
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MUM-2/m__Homo_sapiens__AAD44697

<400>  2790
augaccgugc acaaccugua ccuguucgac agaaacggcg ugugccugca cuacagcgag       60

uggcacagaa agaagcaggc cggcaucccc aaggaggagg aguacaagcu gauguacggc      120

augcuguuca gcaucagaag cuucgugagc aagaugagcc cccuggacau gaaggacggc      180

uuccuggccu uccagaccag cagauacaag cugcacuacu acgagacccc caccggcauc      240

aaggugguga ugaacaccga ccugggcgug ggccccauca gagacgugcu gcaccacauc      300

uacagcgccc uguacgugga gcugguggug aagaaccccc ugugcccccu gggccagacc      360

gugcagagcg agcuguucag aagcagacug gacagcuacg ugagaagccu gcccuucuuc      420

agcgccagag ccggcuga                                                    438


<210>  2791
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MUM-2/m__Homo_sapiens__AAD44697

<400>  2791
augaccgugc acaaccugua ccucuucgac agaaauggcg ucugccugca uuauagcgag       60

uggcaccgga agaaacaggc cgggaucccc aaggaagagg aauacaaacu uauguaugga      120

augcuguuuu ccauucgcuc uuucguuagc aagauguccc cucucgauau gaaagacggc      180

uuucuggcuu uccaaacauc uagauacaaa cuucauuauu acgagacgcc gaccgggauc      240

aaggugguga ugaacacaga ucugggaguc ggccccauuc gggacgugcu ccaccauauc      300

uauagcgccc uguacguuga acuggugguc aagaauccuc ucuguccccu ggggcagacc      360

gugcaguccg agcuuuuucg cucuagacug gauagcuacg uucggucccu cccuuucuuu      420

agcgcgcgcg cuggauga                                                    438


<210>  2792
<211>  1043
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1A__Homo_sapiens__Q9UBC5

<400>  2792

Met Pro Leu Leu Glu Gly Ser Val Gly Val Glu Asp Leu Val Leu Leu 
1               5                   10                  15      


Glu Pro Leu Val Glu Glu Ser Leu Leu Lys Asn Leu Gln Leu Arg Tyr 
            20                  25                  30          


Glu Asn Lys Glu Ile Tyr Thr Tyr Ile Gly Asn Val Val Ile Ser Val 
        35                  40                  45              


Asn Pro Tyr Gln Gln Leu Pro Ile Tyr Gly Pro Glu Phe Ile Ala Lys 
    50                  55                  60                  


Tyr Gln Asp Tyr Thr Phe Tyr Glu Leu Lys Pro His Ile Tyr Ala Leu 
65                  70                  75                  80  


Ala Asn Val Ala Tyr Gln Ser Leu Arg Asp Arg Asp Arg Asp Gln Cys 
                85                  90                  95      


Ile Leu Ile Thr Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Ser Lys 
            100                 105                 110         


Leu Val Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Glu Gln Val 
        115                 120                 125             


Asn Ser Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala 
    130                 135                 140                 


Phe Gly Asn Ala Lys Thr Ile Arg Asn Asn Asn Ser Ser Arg Phe Gly 
145                 150                 155                 160 


Lys Tyr Met Asp Ile Glu Phe Asp Phe Lys Gly Ser Pro Leu Gly Gly 
                165                 170                 175     


Val Ile Thr Asn Tyr Leu Leu Glu Lys Ser Arg Leu Val Lys Gln Leu 
            180                 185                 190         


Lys Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu Leu Ala Gly Ala 
        195                 200                 205             


Asp Glu Gln Leu Leu Lys Ala Leu Lys Leu Glu Arg Asp Thr Thr Gly 
    210                 215                 220                 


Tyr Ala Tyr Leu Asn His Glu Val Ser Arg Val Asp Gly Met Asp Asp 
225                 230                 235                 240 


Ala Ser Ser Phe Arg Ala Val Gln Ser Ala Met Ala Val Ile Gly Phe 
                245                 250                 255     


Ser Glu Glu Glu Ile Arg Gln Val Leu Glu Val Thr Ser Met Val Leu 
            260                 265                 270         


Lys Leu Gly Asn Val Leu Val Ala Asp Glu Phe Gln Ala Ser Gly Ile 
        275                 280                 285             


Pro Ala Ser Gly Ile Arg Asp Gly Arg Gly Val Arg Glu Ile Gly Glu 
    290                 295                 300                 


Met Val Gly Leu Asn Ser Glu Glu Val Glu Arg Ala Leu Cys Ser Arg 
305                 310                 315                 320 


Thr Met Glu Thr Ala Lys Glu Lys Val Val Thr Ala Leu Asn Val Met 
                325                 330                 335     


Gln Ala Gln Tyr Ala Arg Asp Ala Leu Ala Lys Asn Ile Tyr Ser Arg 
            340                 345                 350         


Leu Phe Asp Trp Ile Val Asn Arg Ile Asn Glu Ser Ile Lys Val Gly 
        355                 360                 365             


Ile Gly Glu Lys Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe 
    370                 375                 380                 


Glu Ile Leu Glu Asp Asn Ser Phe Glu Gln Phe Val Ile Asn Tyr Cys 
385                 390                 395                 400 


Asn Glu Lys Leu Gln Gln Val Phe Ile Glu Met Thr Leu Lys Glu Glu 
                405                 410                 415     


Gln Glu Glu Tyr Lys Arg Glu Gly Ile Pro Trp Thr Lys Val Asp Tyr 
            420                 425                 430         


Phe Asp Asn Gly Ile Ile Cys Lys Leu Ile Glu His Asn Gln Arg Gly 
        435                 440                 445             


Ile Leu Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Val Val Ser 
    450                 455                 460                 


Asp Ser Thr Phe Leu Ala Lys Leu Asn Gln Leu Phe Ser Lys His Gly 
465                 470                 475                 480 


His Tyr Glu Ser Lys Val Thr Gln Asn Ala Gln Arg Gln Tyr Asp His 
                485                 490                 495     


Thr Met Gly Leu Ser Cys Phe Arg Ile Cys His Tyr Ala Gly Lys Val 
            500                 505                 510         


Thr Tyr Asn Val Thr Ser Phe Ile Asp Lys Asn Asn Asp Leu Leu Phe 
        515                 520                 525             


Arg Asp Leu Leu Gln Ala Met Trp Lys Ala Gln His Pro Leu Leu Arg 
    530                 535                 540                 


Ser Leu Phe Pro Glu Gly Asn Pro Lys Gln Ala Ser Leu Lys Arg Pro 
545                 550                 555                 560 


Pro Thr Ala Gly Ala Gln Phe Lys Ser Ser Val Ala Ile Leu Met Lys 
                565                 570                 575     


Asn Leu Tyr Ser Lys Ser Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn 
            580                 585                 590         


Glu His Gln Gln Arg Gly Gln Phe Ser Ser Asp Leu Val Ala Thr Gln 
        595                 600                 605             


Ala Arg Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly 
    610                 615                 620                 


Tyr Ala His Arg Gln Gly Tyr Gly Pro Phe Leu Glu Arg Tyr Arg Leu 
625                 630                 635                 640 


Leu Ser Arg Ser Thr Trp Pro His Trp Asn Gly Gly Asp Arg Glu Gly 
                645                 650                 655     


Val Glu Lys Val Leu Gly Glu Leu Ser Met Ser Ser Gly Glu Leu Ala 
            660                 665                 670         


Phe Gly Lys Thr Lys Ile Phe Ile Arg Ser Pro Lys Thr Leu Phe Tyr 
        675                 680                 685             


Leu Glu Glu Gln Arg Arg Leu Arg Leu Gln Gln Leu Ala Thr Leu Ile 
    690                 695                 700                 


Gln Lys Ile Tyr Arg Gly Trp Arg Cys Arg Thr His Tyr Gln Leu Met 
705                 710                 715                 720 


Arg Lys Ser Gln Ile Leu Ile Ser Ser Trp Phe Arg Gly Asn Met Gln 
                725                 730                 735     


Lys Lys Cys Tyr Gly Lys Ile Lys Ala Ser Val Leu Leu Ile Gln Ala 
            740                 745                 750         


Phe Val Arg Gly Trp Lys Ala Arg Lys Asn Tyr Arg Lys Tyr Phe Arg 
        755                 760                 765             


Ser Glu Ala Ala Leu Thr Leu Ala Asp Phe Ile Tyr Lys Ser Met Val 
    770                 775                 780                 


Gln Lys Phe Leu Leu Gly Leu Lys Asn Asn Leu Pro Ser Thr Asn Val 
785                 790                 795                 800 


Leu Asp Lys Thr Trp Pro Ala Ala Pro Tyr Lys Cys Leu Ser Thr Ala 
                805                 810                 815     


Asn Gln Glu Leu Gln Gln Leu Phe Tyr Gln Trp Lys Cys Lys Arg Phe 
            820                 825                 830         


Arg Asp Gln Leu Ser Pro Lys Gln Val Glu Ile Leu Arg Glu Lys Leu 
        835                 840                 845             


Cys Ala Ser Glu Leu Phe Lys Gly Lys Lys Ala Ser Tyr Pro Gln Ser 
    850                 855                 860                 


Val Pro Ile Pro Phe Cys Gly Asp Tyr Ile Gly Leu Gln Gly Asn Pro 
865                 870                 875                 880 


Lys Leu Gln Lys Leu Lys Gly Gly Glu Glu Gly Pro Val Leu Met Ala 
                885                 890                 895     


Glu Ala Val Lys Lys Val Asn Arg Gly Asn Gly Lys Thr Ser Ser Arg 
            900                 905                 910         


Ile Leu Leu Leu Thr Lys Gly His Val Ile Leu Thr Asp Thr Lys Lys 
        915                 920                 925             


Ser Gln Ala Lys Ile Val Ile Gly Leu Asp Asn Val Ala Gly Val Ser 
    930                 935                 940                 


Val Thr Ser Leu Lys Asp Gly Leu Phe Ser Leu His Leu Ser Glu Met 
945                 950                 955                 960 


Ser Ser Val Gly Ser Lys Gly Asp Phe Leu Leu Val Ser Glu His Val 
                965                 970                 975     


Ile Glu Leu Leu Thr Lys Met Tyr Arg Ala Val Leu Asp Ala Thr Gln 
            980                 985                 990         


Arg Gln Leu Thr Val Thr Val Thr Glu Lys Phe Ser Val Arg Phe Lys 
        995                 1000                1005            


Glu Asn Ser Val Ala Val Lys Val Val Gln Gly Pro Ala Gly Gly Asp 
    1010                1015                1020                


Asn Ser Lys Leu Arg Tyr Lys Lys Lys Gly Ser His Cys Leu Glu Val 
1025                1030                1035                1040


Thr Val Gln 
            


<210>  2793
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1A__Homo_sapiens__AAC78645

<400>  2793
augccucucc uggaagguuc ugugggggug gaggaucuug uccuccugga acccuuggug       60

gaggagucac ugcucaagaa ucuucagcuu cgcuaugaaa acaaggagau uuauaccuac      120

auugggaaug uggugaucuc agugaauccc uaucaacagc uucccaucua ugggccagag      180

uucauugcca aauaucaaga cuauacuuuc uaugagcuga agccccauau cuacgcauug      240

gcaaaugugg cguaccaguc acugagggac agggaccgag accaguguau ccucaucaca      300

ggcgagagug gaucagggaa gacugaggcc agcaagcugg ugaugucuua uguggcugcc      360

gucuguggga aaggagagca ggugaacucu gugaaggagc agcugcuaca gucuaaccca      420

gugcuggagg cuuuuggcaa ugccaagacc auucgcaaca acaauuccuc ccgauuugga      480

aaauacaugg auauugaauu ugacuucaag ggaucccccc ucgguggugu caucacaaac      540

uaucugcuug agaaaucccg auuagugaag cagcucaaag gagaaaggaa cuuccacauc      600

uucuaucagc ugcuggcugg agcagaugaa cagcugcuga aggcccugaa gcuugagcgg      660

gauacaacug gcuaugccua ucugaaucau gaaguaucca gaguggaugg cauggacgac      720

gccuccagcu ucagggcugu acagagugca auggcaguga uuggguucuc ggaggaggag      780

auucgacaag ugcuagaggu gacauccaug gugcuaaagc uggggaacgu guugguggcu      840

gaugaguucc aggccagugg gauaccagca aguggcaucc gugaugggag agguguucgg      900

gagauugggg agaugguggg cuugaauuca gaagaaguag agagagcuuu gugcucgagg      960

accauggaaa cagccaagga aaaggugguc acugcacuga auguuaugca ggcucaguau     1020

gcucgggacg cccuggcuaa gaacaucuac agccgccucu uugacuggau agugaaucga     1080

aucaaugaga gcaucaaggu gggcaucggg gaaaagaaga agguaauggg aguccuugau     1140

aucuacgguu uugagauauu agaggauaau agcuuugagc aauuugugau caacuacugc     1200

aaugagaagc ugcagcaggu guucauagag augacccuga aagaagagca agaggaauau     1260

aagagagaag gcauaccgug gacaaaggug gacuacuuug auaauggcau cauuuguaag     1320

cucauugagc auaaucagcg agguauccug gccauguugg augaggagug ccugcggccu     1380

ggggugguca gugacuccac uuuccuagca aagcugaacc agcucuucuc caagcauggc     1440

cacuacgaga gcaaagucac ccagaaugcc cagcgucagu augaccacac caugggccuc     1500

agcugcuucc gcaucugcca cuaugcgggc aaggugacau acaacgugac cagcuuuauu     1560

gacaagaaua augaccuacu cuuccgagac cuguugcagg ccauguggaa ggcccagcac     1620

ccccuccuuc gguccuuguu uccugagggc aauccuaagc aggcaucucu caaacgcccc     1680

ccgacugcug gggcccaguu caagaguucu guggccaucc ucaugaagaa ucuguauucc     1740

aagagcccca acuacaucag gugcauaaag cccaaugagc aucagcagcg aggucaguuc     1800

ucuucagacc ugguggcaac ccaggcucgg uaccugggac ugcuggagaa cguacgggug     1860

cgacgggcag gcuaugccca ccgccagggu uaugggcccu uccuggaaag guaccgauug     1920

cugagccgga gcaccuggcc ucacuggaau gggggagacc gggaaggugu ugagaagguc     1980

cugggggagc ugagcauguc cucgggggag cuggccuuug gcaagacaaa gaucuucauu     2040

agaagcccca agacucuuuu cuaccucgaa gaacagaggc gccugagacu ccagcagcug     2100

gccacacuca uacagaagau uuaccgaggc uggcgcugcc gcacccacua ccaacugaug     2160

cgaaagaguc agauccucau cuccucuugg uuucggggaa acaugcaaaa gaaaugcuau     2220

gggaagauaa aggcauccgu guuauugauc caggcuuuug ugagagggug gaaggcccga     2280

aagaauuauc gcaaauauuu ccggucagag gcugcccuca ccuuggcaga uuucaucuac     2340

aagagcaugg uacagaaauu ccuacugggg cugaagaaca auuugccauc cacaaacguc     2400

uuagacaaga cauggccagc cgcccccuac aagugccuca gcacagcaaa ucaggagcug     2460

cagcagcucu ucuaccagug gaagugcaag agguuccggg aucagcuguc cccgaagcag     2520

guagagaucc ugagggaaaa gcucugugcc agugaacugu ucaagggcaa gaaggcuuca     2580

uauccccaga guguccccau uccauucugu ggugacuaca uugggcugca agggaacccc     2640

aagcugcaga agcugaaagg cggggaggag gggccuguuc ugauggcaga ggccgugaag     2700

aaggucaauc guggcaaugg caagacuucu ucucggauuc uccuccugac caagggccau     2760

gugauucuca cagacaccaa gaagucccag gccaaaauug ucauugggcu agacaaugug     2820

gcuggggugu cagucaccag ccucaaggau gggcucuuua gcuugcaucu gagugagaug     2880

ucaucggugg gcuccaaggg ggacuuccug cuggucagcg agcaugugau ugaacugcug     2940

accaaaaugu accgggcugu gcuggaugcc acgcagaggc agcuuacagu caccgugacu     3000

gagaaguucu cagugagguu caaggagaac aguguggcug ucaaggucgu ccagggcccu     3060

gcagguggug acaacagcaa gcuacgcuac aaaaaaaagg ggagucauug cuuggaggug     3120

acugugcagu ga                                                         3132


<210>  2794
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1A__Homo_sapiens__AAC78645

<400>  2794
augccccugc ucgagggcag cguggggguc gaggaccugg ugcugcucga gccgcuggug       60

gaggaguccc ugcucaagaa ccugcagcug cgcuacgaga acaaggagau cuacaccuac      120

aucggcaacg ucgugaucag cgugaacccc uaccagcagc uccccaucua cgggcccgag      180

uucaucgcca aguaccagga cuacaccuuc uacgagcuga agccgcacau cuacgcccug      240

gcgaacgucg ccuaccaguc ccuccgggac cgcgaccggg accagugcau ccugaucacg      300

ggcgagagcg gguccggcaa gaccgaggcc agcaagcugg ugauguccua cguggccgcc      360

gucugcggca agggggagca ggucaacagc gugaaggagc agcuccugca guccaacccc      420

gugcuggagg cguucggcaa cgccaagacc auccgcaaca acaacagcuc ccgguucggg      480

aaguacaugg acaucgaguu cgacuucaag ggcagccccc ucgggggcgu gaucaccaac      540

uaccugcugg agaagucccg ccucgugaag cagcugaagg gcgagcggaa cuuccacauc      600

uucuaccagc ugcucgccgg ggccgacgag cagcugcuga aggcgcucaa gcuggagcgc      660

gacacgaccg gcuacgccua ccugaaccac gaggucagcc ggguggacgg gauggacgac      720

gccuccagcu uccgcgccgu gcaguccgcc auggcgguca ucggcuucag cgaggaggag      780

auccgccagg ugcucgaggu gaccuccaug guccugaagc ugggcaacgu gcucguggcc      840

gacgaguucc aggccagcgg gauccccgcc agcggcaucc gggacgggcg gggcguccgc      900

gagaucgggg agaugguggg ccugaacucc gaggaggucg agcgggcccu gugcagccgc      960

accauggaga cggcgaagga gaagguggug accgcccuca acgucaugca ggcccaguac     1020

gcccgggacg cccuggcgaa gaacaucuac ucccgccugu ucgacuggau cgugaaccgg     1080

aucaacgaga gcaucaaggu gggcaucggg gagaagaaga aggucauggg cgugcucgac     1140

aucuacgggu ucgagauccu ggaggacaac uccuucgagc aguucgugau caacuacugc     1200

aacgagaagc ugcagcaggu cuucaucgag augacccuca aggaggagca ggaggaguac     1260

aagcgcgagg gcaucccgug gaccaaggug gacuacuucg acaacgggau caucugcaag     1320

cugaucgagc acaaccagcg gggcauccug gccaugcucg acgaggagug ccugcgcccc     1380

ggcgugguca gcgacuccac guuccuggcc aagcucaacc agcuguucag caagcacggg     1440

cacuacgagu ccaaggugac ccagaacgcc cagcgccagu acgaccacac caugggccug     1500

agcugcuucc ggaucugcca cuacgccggg aaggugaccu acaacgucac guccuucauc     1560

gacaagaaca acgaccuccu cuuccgcgac cugcugcagg cgauguggaa ggcccagcac     1620

ccccuccugc ggagccuguu ccccgagggc aacccgaagc aggccucccu caagcgcccg     1680

cccaccgccg gggcgcaguu caagagcucc guggccaucc ugaugaagaa ccuguacagc     1740

aaguccccca acuacauccg gugcaucaag cccaacgagc accagcagcg cggccaguuc     1800

agcuccgacc ucguggccac ccaggcccgg uaccugggcc ugcucgagaa cguccgcgug     1860

cggcgcgccg gguacgcgca ccggcagggc uacgggcccu uccuggagcg cuaccggcug     1920

cucagccgca gcaccuggcc ccacuggaac ggcggcgacc gggagggggu ggagaagguc     1980

cugggcgagc uguccaugag cuccggggag cucgccuucg gcaagacgaa gaucuucauc     2040

cgcagcccca agacccuguu cuaccuggag gagcagcggc gccuccggcu gcagcagcug     2100

gccacccuca uccagaagau cuaccgcggg uggcgcugcc ggacccacua ccagcugaug     2160

cgcaaguccc agauccugau cagcuccugg uuccggggca acaugcagaa gaagugcuac     2220

ggcaagauca aggccagcgu gcuccugauc caggccuucg ugcgcgggug gaaggcgcgg     2280

aagaacuacc gcaaguacuu ccgguccgag gccgcccuga cgcucgccga cuucaucuac     2340

aagagcaugg uccagaaguu ccugcugggc cucaagaaca accugccguc caccaacgug     2400

cuggacaaga ccuggcccgc cgcgcccuac aagugccuca gcaccgccaa ccaggagcug     2460

cagcagcugu ucuaccagug gaagugcaag cgcuuccggg accagcucuc ccccaagcag     2520

gucgagaucc ugcgcgagaa gcugugcgcc agcgagcugu ucaaggggaa gaaggccucc     2580

uacccgcaga gcgugcccau ccccuucugc ggcgacuaca ucgggcugca gggcaacccc     2640

aagcugcaga agcucaaggg cggggaggag ggcccggugc ugauggcgga ggccgugaag     2700

aaggucaacc gggggaacgg caagacgucc agccgcaucc ugcuccugac caaggggcac     2760

gugauccuga ccgacaccaa gaagucccag gccaagaucg ugaucggccu cgacaacguc     2820

gccggcguga gcgugacgag ccugaaggac gggcuguucu cccuccaccu gagcgagaug     2880

uccagcgucg gcuccaaggg ggacuuccug cucgugagcg agcacgugau cgagcugcug     2940

accaagaugu accgggccgu ccucgacgcg acccagcgcc agcugaccgu gacggugacc     3000

gagaaguucu ccguccgguu caaggagaac agcguggccg ugaaggucgu gcagggcccc     3060

gccgggggcg acaacuccaa gcugcgcuac aagaagaagg gcagccacug ccucgaggug     3120

accguccagu ga                                                         3132


<210>  2795
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1A__Homo_sapiens__AAC78645

<400>  2795
augccccucc ucgagggcuc cgucggcguc gaggaccucg uccuccucga gccccucguc       60

gaggaguccc uccucaagaa ccuccagcuc cgcuacgaga acaaggagau cuacaccuac      120

aucggcaacg ucgucaucuc cgucaacccc uaccagcagc uccccaucua cggccccgag      180

uucaucgcca aguaccagga cuacaccuuc uacgagcuca agccccacau cuacgcccuc      240

gccaacgucg ccuaccaguc ccuccgcgac cgcgaccgcg accagugcau ccucaucacc      300

ggcgaguccg gcuccggcaa gaccgaggcc uccaagcucg ucauguccua cgucgccgcc      360

gucugcggca agggcgagca ggucaacucc gucaaggagc agcuccucca guccaacccc      420

guccucgagg ccuucggcaa cgccaagacc auccgcaaca acaacuccuc ccgcuucggc      480

aaguacaugg acaucgaguu cgacuucaag ggcucccccc ucggcggcgu caucaccaac      540

uaccuccucg agaagucccg ccucgucaag cagcucaagg gcgagcgcaa cuuccacauc      600

uucuaccagc uccucgccgg cgccgacgag cagcuccuca aggcccucaa gcucgagcgc      660

gacaccaccg gcuacgccua ccucaaccac gaggucuccc gcgucgacgg cauggacgac      720

gccuccuccu uccgcgccgu ccaguccgcc auggccguca ucggcuucuc cgaggaggag      780

auccgccagg uccucgaggu caccuccaug guccucaagc ucggcaacgu ccucgucgcc      840

gacgaguucc aggccuccgg cauccccgcc uccggcaucc gcgacggccg cggcguccgc      900

gagaucggcg agauggucgg ccucaacucc gaggaggucg agcgcgcccu cugcucccgc      960

accauggaga ccgccaagga gaaggucguc accgcccuca acgucaugca ggcccaguac     1020

gcccgcgacg cccucgccaa gaacaucuac ucccgccucu ucgacuggau cgucaaccgc     1080

aucaacgagu ccaucaaggu cggcaucggc gagaagaaga aggucauggg cguccucgac     1140

aucuacggcu ucgagauccu cgaggacaac uccuucgagc aguucgucau caacuacugc     1200

aacgagaagc uccagcaggu cuucaucgag augacccuca aggaggagca ggaggaguac     1260

aagcgcgagg gcauccccug gaccaagguc gacuacuucg acaacggcau caucugcaag     1320

cucaucgagc acaaccagcg cggcauccuc gccaugcucg acgaggagug ccuccgcccc     1380

ggcgucgucu ccgacuccac cuuccucgcc aagcucaacc agcucuucuc caagcacggc     1440

cacuacgagu ccaaggucac ccagaacgcc cagcgccagu acgaccacac caugggccuc     1500

uccugcuucc gcaucugcca cuacgccggc aaggucaccu acaacgucac cuccuucauc     1560

gacaagaaca acgaccuccu cuuccgcgac cuccuccagg ccauguggaa ggcccagcac     1620

ccccuccucc gcucccucuu ccccgagggc aaccccaagc aggccucccu caagcgcccc     1680

cccaccgccg gcgcccaguu caaguccucc gucgccaucc ucaugaagaa ccucuacucc     1740

aaguccccca acuacauccg cugcaucaag cccaacgagc accagcagcg cggccaguuc     1800

uccuccgacc ucgucgccac ccaggcccgc uaccucggcc uccucgagaa cguccgcguc     1860

cgccgcgccg gcuacgccca ccgccagggc uacggccccu uccucgagcg cuaccgccuc     1920

cucucccgcu ccaccuggcc ccacuggaac ggcggcgacc gcgagggcgu cgagaagguc     1980

cucggcgagc ucuccauguc cuccggcgag cucgccuucg gcaagaccaa gaucuucauc     2040

cgcuccccca agacccucuu cuaccucgag gagcagcgcc gccuccgccu ccagcagcuc     2100

gccacccuca uccagaagau cuaccgcggc uggcgcugcc gcacccacua ccagcucaug     2160

cgcaaguccc agauccucau cuccuccugg uuccgcggca acaugcagaa gaagugcuac     2220

ggcaagauca aggccuccgu ccuccucauc caggccuucg uccgcggcug gaaggcccgc     2280

aagaacuacc gcaaguacuu ccgcuccgag gccgcccuca cccucgccga cuucaucuac     2340

aaguccaugg uccagaaguu ccuccucggc cucaagaaca accuccccuc caccaacguc     2400

cucgacaaga ccuggcccgc cgcccccuac aagugccucu ccaccgccaa ccaggagcuc     2460

cagcagcucu ucuaccagug gaagugcaag cgcuuccgcg accagcucuc ccccaagcag     2520

gucgagaucc uccgcgagaa gcucugcgcc uccgagcucu ucaagggcaa gaaggccucc     2580

uacccccagu ccguccccau ccccuucugc ggcgacuaca ucggccucca gggcaacccc     2640

aagcuccaga agcucaaggg cggcgaggag ggccccgucc ucauggccga ggccgucaag     2700

aaggucaacc gcggcaacgg caagaccucc ucccgcaucc uccuccucac caagggccac     2760

gucauccuca ccgacaccaa gaagucccag gccaagaucg ucaucggccu cgacaacguc     2820

gccggcgucu ccgucaccuc ccucaaggac ggccucuucu cccuccaccu cuccgagaug     2880

uccuccgucg gcuccaaggg cgacuuccuc cucgucuccg agcacgucau cgagcuccuc     2940

accaagaugu accgcgccgu ccucgacgcc acccagcgcc agcucaccgu caccgucacc     3000

gagaaguucu ccguccgcuu caaggagaac uccgucgccg ucaaggucgu ccagggcccc     3060

gccggcggcg acaacuccaa gcuccgcuac aagaagaagg gcucccacug ccucgagguc     3120

accguccagu ga                                                         3132


<210>  2796
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1A__Homo_sapiens__AAC78645

<400>  2796
augccccugc ucgagggcag cguggggguc gaagaccuug uucuguugga gccuuuagug       60

gaagaguccc ugcuaaagaa ccuccagcug agauacgaaa auaaagagau cuauaccuac      120

auuggaaacg uagugauauc ugucaaucca uaucaacagc uuccgaucua cggucccgag      180

uucauugcca aguaucagga uuacacauuu uaugaacuga aaccucacau cuacgcuuug      240

gcaaacgugg ccuaccaguc acucagggac cgggaucgcg accaaugcau ucugaucacu      300

ggcgagagug ggagcggaaa gacggaagcg uccaaacugg uuaugucuua uguggcugcc      360

gucuguggca agggugagca gguaaauucg gugaaggagc agcucuuaca gucaaaccca      420

guucuggaag cauucgggaa ugccaaaacc auacgaaaca auaacagcag ucguuuugga      480

aaguacaugg auaucgaguu cgacuuuaaa ggcagucccc uuggcggggu gauuacaaau      540

uauuugcugg aaaagucuag gcuagucaaa caacucaagg gagagagaaa cuuccauauc      600

uuuuaccagc ugcuugcugg ugcagaugaa cagcuguuga aggcccucaa acuggagcgg      660

gacacuaccg gcuaugcuua cuuaaaucac gaggugagcc gcguggaugg gauggacgau      720

gccuccucau ucagagcggu ccagagugca auggccguua uuggauuuag cgaagaggaa      780

aucaggcaag ugcuggaggu aacaucuaug gugcucaaac uuggcaacgu ccugguggcu      840

gacgaguucc aggccuccgg uauaccugca ucagggauuc gggauggacg cggcguucga      900

gaaaucggcg agaugguggg guugaauagc gaagaggucg aaagagcucu augcaguagg      960

accauggaga cugccaagga aaagguggua acagcgcuga acguuaugca ggcccaauau     1020

gcacgggacg cucucgccaa aaacauuuac ucucgucugu uugacuggau cgugaaucgc     1080

aucaacgagu ccauuaaggu cggaauaggu gagaaaaaga aggugauggg cguccuugau     1140

aucuacgggu ucgaaauucu ggaggacaau agcuuugaac aguucgugau caacuauugu     1200

aaugagaaau ugcagcaggu uuucauagag augacccuca aggaggaaca agaagaguac     1260

aaaagagaag gcauuccaug gacgaaggug gauuauuuug acaacggaau caucugcaaa     1320

cugauugagc auaaucagag ggguaucuua gcuaugcugg augaggaaug ucuacggccc     1380

gggguagucu cggacucuac uuuccucgcc aagcugaacc agcuguuuuc caagcacggc     1440

cauuacgagu caaaagugac ccagaaugca caacgacagu augaucacac aaugggauug     1500

aguugcuucc gcauuuguca cuacgccggc aagguuacuu auaacgugac cagcuuuaua     1560

gacaaaaaua acgaucuucu cuucagagac cugcuucagg cuauguggaa ggcgcagcau     1620

ccucuguuga ggucccucuu uccagaaggg aauccgaaac aagcaucucu gaagcggccc     1680

ccuacagccg gagcucaguu caagagcuca gucgccaucu uaaugaaaaa ccuguacagu     1740

aaguccccaa auuacauucg cugcaucaaa cccaacgagc accagcagag aggucaauuu     1800

agcucugauc uaguggcaac ccaggccagg uaucucggcc ugcuugaaaa cguacgugug     1860

cggcgagcug gguacgccca uagacaggga uauggcccuu ucuuggagag guaccgccug     1920

cucucacgga guacguggcc acacuggaau gguggggaca gagagggcgu ugaaaagguc     1980

cugggagagu uaagcauguc cucuggcgaa cuggcauuug ggaaaacuaa gaucuucauu     2040

aggucgccca agacauuguu uuaucuugag gaacaacgcc gacuccggcu gcagcagcua     2100

gcgacccuga uacagaaaau cuaccgugga uggagaugua ggacucacua ucaacucaug     2160

cgcaagagcc agauucugau cuccucaugg uuccggggua acaugcagaa aaagugcuac     2220

ggcaaaauua aggcuagugu gcuuuugauc caggccuucg ugagagggug gaaagcaagg     2280

aagaauuacc gaaaguauuu ucgcucugag gccgcucuga cauuagccga cuucauauac     2340

aaaagcaugg uccaaaaguu ucuccuggga cuuaaaaaca aucugccguc caccaacguu     2400

uuggauaaga cguggccugc agcucccuau aaaugucucu caaccgccaa ucaggagcug     2460

cagcagcuau ucuaccaaug gaagugcaag cgguuuagag accagcugag cccaaaacag     2520

guggaaaucc ucagggagaa gcugugcgcg ucugaacuuu ucaaaggcaa gaaagccucc     2580

uauccucaaa gugugcccau uccauuuugu ggugauuaca ucggguugca gggcaacccc     2640

aagcugcaga aguuaaaagg aggcgaggag gggccuguac ucauggcuga agcagucaag     2700

aaagugaauc guggaaacgg caagacaagc ucucgcauuc ugcuucugac uaaaggucau     2760

guuauccuaa ccgacacaaa gaagucccag gccaaaauag ugauugggcu cgauaauguc     2820

gcuggagugu caguuacuuc ccugaaggac ggcuuguuca gccugcacuu aucggagaug     2880

uccucugugg guagcaaagg cgauuuucuc cugguaucag aacaugucau cgagcuucug     2940

accaagaugu aucgggccgu guuggacgca acacaaagac agcucaccgu gacugucacg     3000

gaaaaauuca guguuagguu uaaggagaac uccguggcgg uaaaaguggu ccaggggcca     3060

gccggaggcg auaauucuaa gcugcgauac aagaaaaagg ggagccacug ccuagaggug     3120

acaguucagu ga                                                         3132


<210>  2797
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1A__Homo_sapiens__AAC78645

<400>  2797
augccccugc uggagggcag cgugggcgug gaggaccugg ugcugcugga gccccuggug       60

gaggagagcc ugcugaagaa ccugcagcug agauacgaga acaaggagau cuacaccuac      120

aucggcaacg uggugaucag cgugaacccc uaccagcagc ugcccaucua cggccccgag      180

uucaucgcca aguaccagga cuacaccuuc uacgagcuga agccccacau cuacgcccug      240

gccaacgugg ccuaccagag ccugagagac agagacagag accagugcau ccugaucacc      300

ggcgagagcg gcagcggcaa gaccgaggcc agcaagcugg ugaugagcua cguggccgcc      360

gugugcggca agggcgagca ggugaacagc gugaaggagc agcugcugca gagcaacccc      420

gugcuggagg ccuucggcaa cgccaagacc aucagaaaca acaacagcag cagauucggc      480

aaguacaugg acaucgaguu cgacuucaag ggcagccccc ugggcggcgu gaucaccaac      540

uaccugcugg agaagagcag acuggugaag cagcugaagg gcgagagaaa cuuccacauc      600

uucuaccagc ugcuggccgg cgccgacgag cagcugcuga aggcccugaa gcuggagaga      660

gacaccaccg gcuacgccua ccugaaccac gaggugagca gaguggacgg cauggacgac      720

gccagcagcu ucagagccgu gcagagcgcc auggccguga ucggcuucag cgaggaggag      780

aucagacagg ugcuggaggu gaccagcaug gugcugaagc ugggcaacgu gcugguggcc      840

gacgaguucc aggccagcgg cauccccgcc agcggcauca gagacggcag aggcgugaga      900

gagaucggcg agaugguggg ccugaacagc gaggaggugg agagagcccu gugcagcaga      960

accauggaga ccgccaagga gaagguggug accgcccuga acgugaugca ggcccaguac     1020

gccagagacg cccuggccaa gaacaucuac agcagacugu ucgacuggau cgugaacaga     1080

aucaacgaga gcaucaaggu gggcaucggc gagaagaaga aggugauggg cgugcuggac     1140

aucuacggcu ucgagauccu ggaggacaac agcuucgagc aguucgugau caacuacugc     1200

aacgagaagc ugcagcaggu guucaucgag augacccuga aggaggagca ggaggaguac     1260

aagagagagg gcauccccug gaccaaggug gacuacuucg acaacggcau caucugcaag     1320

cugaucgagc acaaccagag aggcauccug gccaugcugg acgaggagug ccugagaccc     1380

ggcgugguga gcgacagcac cuuccuggcc aagcugaacc agcuguucag caagcacggc     1440

cacuacgaga gcaaggugac ccagaacgcc cagagacagu acgaccacac caugggccug     1500

agcugcuuca gaaucugcca cuacgccggc aaggugaccu acaacgugac cagcuucauc     1560

gacaagaaca acgaccugcu guucagagac cugcugcagg ccauguggaa ggcccagcac     1620

ccccugcuga gaagccuguu ccccgagggc aaccccaagc aggccagccu gaagagaccc     1680

cccaccgccg gcgcccaguu caagagcagc guggccaucc ugaugaagaa ccuguacagc     1740

aagagcccca acuacaucag augcaucaag cccaacgagc accagcagag aggccaguuc     1800

agcagcgacc ugguggccac ccaggccaga uaccugggcc ugcuggagaa cgugagagug     1860

agaagagccg gcuacgccca cagacagggc uacggccccu uccuggagag auacagacug     1920

cugagcagaa gcaccuggcc ccacuggaac ggcggcgaca gagagggcgu ggagaaggug     1980

cugggcgagc ugagcaugag cagcggcgag cuggccuucg gcaagaccaa gaucuucauc     2040

agaagcccca agacccuguu cuaccuggag gagcagagaa gacugagacu gcagcagcug     2100

gccacccuga uccagaagau cuacagaggc uggagaugca gaacccacua ccagcugaug     2160

agaaagagcc agauccugau cagcagcugg uucagaggca acaugcagaa gaagugcuac     2220

ggcaagauca aggccagcgu gcugcugauc caggccuucg ugagaggcug gaaggccaga     2280

aagaacuaca gaaaguacuu cagaagcgag gccgcccuga cccuggccga cuucaucuac     2340

aagagcaugg ugcagaaguu ccugcugggc cugaagaaca accugcccag caccaacgug     2400

cuggacaaga ccuggcccgc cgcccccuac aagugccuga gcaccgccaa ccaggagcug     2460

cagcagcugu ucuaccagug gaagugcaag agauucagag accagcugag ccccaagcag     2520

guggagaucc ugagagagaa gcugugcgcc agcgagcugu ucaagggcaa gaaggccagc     2580

uacccccaga gcgugcccau ccccuucugc ggcgacuaca ucggccugca gggcaacccc     2640

aagcugcaga agcugaaggg cggcgaggag ggccccgugc ugauggccga ggccgugaag     2700

aaggugaaca gaggcaacgg caagaccagc agcagaaucc ugcugcugac caagggccac     2760

gugauccuga ccgacaccaa gaagagccag gccaagaucg ugaucggccu ggacaacgug     2820

gccggcguga gcgugaccag ccugaaggac ggccuguuca gccugcaccu gagcgagaug     2880

agcagcgugg gcagcaaggg cgacuuccug cuggugagcg agcacgugau cgagcugcug     2940

accaagaugu acagagccgu gcuggacgcc acccagagac agcugaccgu gaccgugacc     3000

gagaaguuca gcgugagauu caaggagaac agcguggccg ugaagguggu gcagggcccc     3060

gccggcggcg acaacagcaa gcugagauac aagaagaagg gcagccacug ccuggaggug     3120

accgugcagu ga                                                         3132


<210>  2798
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1A__Homo_sapiens__AAC78645

<400>  2798
augccccugc ucgagggcag cguggggguc gaagaccugg uucuucugga gccucucgug       60

gaagaguccc ugcuuaagaa ccugcagcuc agauacgaaa auaaagagau cuauaccuac      120

auuggaaacg uggucaucuc ugugaauccg uaucaacagc ugcccauuua cggcccugag      180

uucaucgcca aguaucagga uuacacauuu uaugaacuga aaccccacau uuacgcucuc      240

gccaacguug cguaccagag ccugcgggac cgcgauagag accaaugcau ccuuaucacg      300

ggggaguccg gaucuggcaa gaccgaagcu agcaaacugg ugauguccua ugucgccgcc      360

guguguggga agggagagca gguuaauucu gugaaggagc agcuccugca gagcaacccu      420

guccuugaag cguucggcaa ugccaaaaca auucggaaca auaacuccag ccgcuuuggc      480

aaguacaugg auaucgaguu cgacuuuaaa gggucucccc ugggaggcgu gauuaccaau      540

uaucuccugg aaaaguccag acuggugaaa caacucaagg gggagcggaa cuuccauauc      600

uuuuaccagc ugcuugcugg agccgaugaa cagcugcuca aggcgcugaa acuugagcgc      660

gacacaaccg gcuaugccua ccugaaucac gaggucagca gaguugaugg gauggacgau      720

gcuucuuccu uccgggccgu gcagagcgcu auggccguga uuggauuuuc ugaagaggaa      780

auccgccaag uccucgaggu gacauccaug guucugaagc ugggcaacgu gcucgucgcg      840

gacgaguucc aggccagcgg cauuccugcu uccgggauca gagauggacg gggcgugcgc      900

gagaucgggg agaugguugg acuuaauucu gaagaggugg aaagagcccu gugcagccgg      960

accauggaga cggcuaaaga aaaggucgug accgcccuga acgucaugca ggcccaauau     1020

gcucgcgacg cgcucgccaa aaacauuuac uccagacugu uugacuggau cgugaaucgg     1080

auuaacgaga gcaucaaggu uggcauuggg gagaaaaaga aggugauggg aguccuugau     1140

aucuacggcu ucgaaauccu ggaggacaau ucuuuugaac aguucgugau uaacuauugu     1200

aaugagaaac uccagcaggu uuucaucgag augacacuga aggaagaaca agaagaguac     1260

aaaagagaag gcauuccgug gaccaaggug gauuauuuug acaacgggau cauuugcaaa     1320

cugaucgagc auaaucagcg cggaauccuc gcuaugcugg augaggaaug ucuucggccc     1380

ggcgucgugu ccgacagcac auuccuggcc aagcucaacc agcuguuuuc uaagcacggg     1440

cauuacgaga gcaaagugac ccagaaugcc caaagacagu augaucacac gaugggacug     1500

uccugcuucc gcauuuguca cuacgcuggc aagguuacau auaacgucac cucuuuuauc     1560

gacaaaaaua acgaucuucu cuuccgggac cugcugcagg ccauguggaa ggcgcagcau     1620

ccucuccuga gaagccuuuu ucccgaaggg aauccuaaac aggcuucccu gaagcggccc     1680

ccgacagccg gcgcccaauu caagagcucu guggcuauuc ucaugaaaaa ccuguacucc     1740

aagagcccua auuacauccg gugcauuaaa cccaacgagc accagcagag aggacaauuu     1800

ucuuccgauc ugguggccac ccaggcucgc uaucuuggcc uccuggaaaa cguccgggug     1860

agacgcgccg gguacgcgca ucggcaggga uauggcccuu uccuggagag auaccggcuc     1920

cugagccgcu ccaccuggcc ccacuggaau gggggagaca gagagggcgu ugaaaaggug     1980

cuuggggagc ugucuaugag cuccggcgaa cucgccuuug gaaaaacaaa gaucuucauu     2040

cggucuccca agacgcuguu uuaucuggag gaacaaagac gccuucggcu ccagcagcug     2100

gcuacccuga uccagaaaau cuacagaggc uggcgcugua gaacacacua ucaacucaug     2160

cgcaagagcc agauucugau cuccagcugg uuccgcggga acaugcagaa aaagugcuac     2220

ggaaaaauua aggccucugu ccuucugauc caggcuuucg ugagaggcug gaaagcccgg     2280

aagaauuacc gcaaguauuu uagauccgag gcggcccuca cccuggcuga cuucauuuac     2340

aaaagcaugg uucaaaaguu ucugcuuggg cucaaaaaca aucugccuuc uacaaacgug     2400

cuggauaaga ccuggccggc cgcucccuau aaaugucucu ccacggccaa ucaggagcug     2460

cagcagcuuu ucuaccaaug gaagugcaag cgguuucgcg accagcugag cccuaaacag     2520

gucgaaaucc ucagagagaa gcugugcgcc ucugaacugu ucaaaggaaa gaaagcuagc     2580

uauccccaau ccgugccuau ccccuuuugu ggcgauuaca uugggcuuca gggcaacccg     2640

aagcugcaga agcucaaagg aggcgaggag gggccuguuc ugauggcgga agccgugaag     2700

aaagucaauc ggggaaacgg caagacaagc ucucgcaucc uccugcuuac caaagggcau     2760

gugauucuga ccgacacaaa gaagucccag gcuaaaaucg ugauuggacu cgauaauguc     2820

gccggcguua gcgugaccuc ccugaaggac gggcuguucu cucuucaccu gagcgagaug     2880

uccucugugg gcagcaaagg agauuuucuc cuggucuccg aacaugugau cgagcuccug     2940

acaaagaugu auagagccgu ucuugacgcu acgcaacggc agcugaccgu gacagucacc     3000

gaaaaauucu cugugagauu uaaggagaac agcguugccg ugaaagucgu gcagggcccc     3060

gcugggggag auaauuccaa gcuccgcuac aagaaaaagg gcagccacug ccuggagguu     3120

acagugcagu ga                                                         3132


<210>  2799
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1B__Homo_sapiens__O43795

<400>  2799

Met Ala Lys Met Glu Val Lys Thr Ser Leu Leu Asp Asn Met Ile Gly 
1               5                   10                  15      


Val Gly Asp Met Val Leu Leu Glu Pro Leu Asn Glu Glu Thr Phe Ile 
            20                  25                  30          


Asn Asn Leu Lys Lys Arg Phe Asp His Ser Glu Ile Tyr Thr Tyr Ile 
        35                  40                  45              


Gly Ser Val Val Ile Ser Val Asn Pro Tyr Arg Ser Leu Pro Ile Tyr 
    50                  55                  60                  


Ser Pro Glu Lys Val Glu Glu Tyr Arg Asn Arg Asn Phe Tyr Glu Leu 
65                  70                  75                  80  


Ser Pro His Ile Phe Ala Leu Ser Asp Glu Ala Tyr Arg Ser Leu Arg 
                85                  90                  95      


Asp Gln Asp Lys Asp Gln Cys Ile Leu Ile Thr Gly Glu Ser Gly Ala 
            100                 105                 110         


Gly Lys Thr Glu Ala Ser Lys Leu Val Met Ser Tyr Val Ala Ala Val 
        115                 120                 125             


Cys Gly Lys Gly Ala Glu Val Asn Gln Val Lys Glu Gln Leu Leu Gln 
    130                 135                 140                 


Ser Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn 
145                 150                 155                 160 


Asp Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp Ile Glu Phe Asp Phe 
                165                 170                 175     


Lys Gly Asp Pro Leu Gly Gly Val Ile Ser Asn Tyr Leu Leu Glu Lys 
            180                 185                 190         


Ser Arg Val Val Lys Gln Pro Arg Gly Glu Arg Asn Phe His Val Phe 
        195                 200                 205             


Tyr Gln Leu Leu Ser Gly Ala Ser Glu Glu Leu Leu Asn Lys Leu Lys 
    210                 215                 220                 


Leu Glu Arg Asp Phe Ser Arg Tyr Asn Tyr Leu Ser Leu Asp Ser Ala 
225                 230                 235                 240 


Lys Val Asn Gly Val Asp Asp Ala Ala Asn Phe Arg Thr Val Arg Asn 
                245                 250                 255     


Ala Met Gln Ile Val Gly Phe Met Asp His Glu Ala Glu Ser Val Leu 
            260                 265                 270         


Ala Val Val Ala Ala Val Leu Lys Leu Gly Asn Ile Glu Phe Lys Pro 
        275                 280                 285             


Glu Ser Arg Val Asn Gly Leu Asp Glu Ser Lys Ile Lys Asp Lys Asn 
    290                 295                 300                 


Glu Leu Lys Glu Ile Cys Glu Leu Thr Gly Ile Asp Gln Ser Val Leu 
305                 310                 315                 320 


Glu Arg Ala Phe Ser Phe Arg Thr Val Glu Ala Lys Gln Glu Lys Val 
                325                 330                 335     


Ser Thr Thr Leu Asn Val Ala Gln Ala Tyr Tyr Ala Arg Asp Ala Leu 
            340                 345                 350         


Ala Lys Asn Leu Tyr Ser Arg Leu Phe Ser Trp Leu Val Asn Arg Ile 
        355                 360                 365             


Asn Glu Ser Ile Lys Ala Gln Thr Lys Val Arg Lys Lys Val Met Gly 
    370                 375                 380                 


Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Glu Asp Asn Ser Phe Glu 
385                 390                 395                 400 


Gln Phe Ile Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Ile Phe Ile 
                405                 410                 415     


Glu Leu Thr Leu Lys Glu Glu Gln Glu Glu Tyr Ile Arg Glu Asp Ile 
            420                 425                 430         


Glu Trp Thr His Ile Asp Tyr Phe Asn Asn Ala Ile Ile Cys Asp Leu 
        435                 440                 445             


Ile Glu Asn Asn Thr Asn Gly Ile Leu Ala Met Leu Asp Glu Glu Cys 
    450                 455                 460                 


Leu Arg Pro Gly Thr Val Thr Asp Glu Thr Phe Leu Glu Lys Leu Asn 
465                 470                 475                 480 


Gln Val Cys Ala Thr His Gln His Phe Glu Ser Arg Met Ser Lys Cys 
                485                 490                 495     


Ser Arg Phe Leu Asn Asp Thr Ser Leu Pro His Ser Cys Phe Arg Ile 
            500                 505                 510         


Gln His Tyr Ala Gly Lys Val Leu Tyr Gln Val Glu Gly Phe Val Asp 
        515                 520                 525             


Lys Asn Asn Asp Leu Leu Tyr Arg Asp Leu Ser Gln Ala Met Trp Lys 
    530                 535                 540                 


Ala Ser His Ala Leu Ile Lys Ser Leu Phe Pro Glu Gly Asn Pro Ala 
545                 550                 555                 560 


Lys Ile Asn Leu Lys Arg Pro Pro Thr Ala Gly Ser Gln Phe Lys Ala 
                565                 570                 575     


Ser Val Ala Thr Leu Met Lys Asn Leu Gln Thr Lys Asn Pro Asn Tyr 
            580                 585                 590         


Ile Arg Cys Ile Lys Pro Asn Asp Lys Lys Ala Ala His Ile Phe Asn 
        595                 600                 605             


Glu Ala Leu Val Cys His Gln Ile Arg Tyr Leu Gly Leu Leu Glu Asn 
    610                 615                 620                 


Val Arg Val Arg Arg Ala Gly Tyr Ala Phe Arg Gln Ala Tyr Glu Pro 
625                 630                 635                 640 


Cys Leu Glu Arg Tyr Lys Met Leu Cys Lys Gln Thr Trp Pro His Trp 
                645                 650                 655     


Lys Gly Pro Ala Arg Ser Gly Val Glu Val Leu Phe Asn Glu Leu Glu 
            660                 665                 670         


Ile Pro Val Glu Glu Tyr Ser Phe Gly Arg Ser Lys Ile Phe Ile Arg 
        675                 680                 685             


Asn Pro Arg Thr Leu Phe Lys Leu Glu Asp Leu Arg Lys Gln Arg Leu 
    690                 695                 700                 


Glu Asp Leu Ala Thr Leu Ile Gln Lys Ile Tyr Arg Gly Trp Lys Cys 
705                 710                 715                 720 


Arg Thr His Phe Leu Leu Met Lys Lys Ser Gln Ile Val Ile Ala Ala 
                725                 730                 735     


Trp Tyr Arg Arg Tyr Ala Gln Gln Lys Arg Tyr Gln Gln Thr Lys Ser 
            740                 745                 750         


Ser Ala Leu Val Ile Gln Ser Tyr Ile Arg Gly Trp Lys Ala Arg Lys 
        755                 760                 765             


Ile Leu Arg Glu Leu Lys His Gln Lys Arg Cys Lys Glu Ala Val Thr 
    770                 775                 780                 


Thr Ile Ala Ala Tyr Trp His Gly Thr Gln Ala Arg Arg Glu Leu Arg 
785                 790                 795                 800 


Arg Leu Lys Glu Glu Ala Arg Asn Lys His Ala Ile Ala Val Ile Trp 
                805                 810                 815     


Ala Tyr Trp Leu Gly Ser Lys Ala Arg Arg Glu Leu Lys Arg Leu Lys 
            820                 825                 830         


Glu Glu Ala Arg Arg Lys His Ala Val Ala Val Ile Trp Ala Tyr Trp 
        835                 840                 845             


Leu Gly Leu Lys Val Arg Arg Glu Tyr Arg Lys Phe Phe Arg Ala Asn 
    850                 855                 860                 


Ala Gly Lys Lys Ile Tyr Glu Phe Thr Leu Gln Arg Ile Val Gln Lys 
865                 870                 875                 880 


Tyr Phe Leu Glu Met Lys Asn Lys Met Pro Ser Leu Ser Pro Ile Asp 
                885                 890                 895     


Lys Asn Trp Pro Ser Arg Pro Tyr Leu Phe Leu Asp Ser Thr His Lys 
            900                 905                 910         


Glu Leu Lys Arg Ile Phe His Leu Trp Arg Cys Lys Lys Tyr Arg Asp 
        915                 920                 925             


Gln Phe Thr Asp Gln Gln Lys Leu Ile Tyr Glu Glu Lys Leu Glu Ala 
    930                 935                 940                 


Ser Glu Leu Phe Lys Asp Lys Lys Ala Leu Tyr Pro Ser Ser Val Gly 
945                 950                 955                 960 


Gln Pro Phe Gln Gly Ala Tyr Leu Glu Ile Asn Lys Asn Pro Lys Tyr 
                965                 970                 975     


Lys Lys Leu Lys Asp Ala Ile Glu Glu Lys Ile Ile Ile Ala Glu Val 
            980                 985                 990         


Val Asn Lys Ile Asn Arg Ala Asn Gly Lys Ser Thr Ser Arg Ile Phe 
        995                 1000                1005            


Leu Leu Thr Asn Asn Asn Leu Leu Leu Ala Asp Gln Lys Ser Gly Gln 
    1010                1015                1020                


Ile Lys Ser Glu Val Pro Leu Val Asp Val Thr Lys Val Ser Met Ser 
1025                1030                1035                1040


Ser Gln Asn Asp Gly Phe Phe Ala Val His Leu Lys Glu Gly Ser Glu 
                1045                1050                1055    


Ala Ala Ser Lys Gly Asp Phe Leu Phe Ser Ser Asp His Leu Ile Glu 
            1060                1065                1070        


Met Ala Thr Lys Leu Tyr Arg Thr Thr Leu Ser Gln Thr Lys Gln Lys 
        1075                1080                1085            


Leu Asn Ile Glu Ile Ser Asp Glu Phe Leu Val Gln Phe Arg Gln Asp 
    1090                1095                1100                


Lys Val Cys Val Lys Phe Ile Gln Gly Asn Gln Lys Asn Gly Ser Val 
1105                1110                1115                1120


Pro Thr Cys Lys Arg Lys Asn Asn Arg Leu Leu Glu Val Ala Val Pro 
                1125                1130                1135    






<210>  2800
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1B__Homo_sapiens__AAH53558

<400>  2800
auggccaaaa uggaggugaa aaccucacuu cuggacaaua ugauuggagu uggggauaug       60

guucuuuuag aaccucucaa ugaggagacc uucaucaaca accucaagaa gcgcuuugac      120

cacagugaaa uauacacuua cauuggaagu gugguuauau cuguuaaccc auaucggucu      180

uuacccauuu auucaccaga gaaaguggaa gaauacagga acagaaauuu uuaugaacug      240

agcccucaca ucuuugcccu uucggaugaa gcauacagau cccuacgaga ucaagauaag      300

gaccaaugua uucucauuac uggggaaagu ggagcaggaa aaacagaggc caguaagcuu      360

gucauguccu auguggcagc uguuugugga aaaggagcag aaguuaauca aguuaaagaa      420

cagcuuuuac aguccaaccc gguccuggaa gcuuuuggaa augccaaaac uguaaggaau      480

gacaacuccu cuagauuugg caaauauaug gauauugaau uugacuuuaa aggcgaucca      540

cuaggaggag uaauaaguaa cuaucuuuua gagaaaucuc ggguuguuaa acagccaaga      600

ggugaaagaa acuuccaugu guucuaucag cugcucucug gugccucuga agagcuccuc      660

aauaaacuua agcuugagag ggauuucagc agguauaacu accugagucu ggauucggcc      720

aaagugaaug gaguggauga ugcagcaaau uuuagaaccg ugcggaaugc caugcagauu      780

gugggcuuua uggaucauga agcugagucu gucuuggcgg ugguggcagc aguguugaaa      840

cuggggaaca uugaguucaa gcccgaaucu cgagugaaug gucuagauga aagcaaaauc      900

aaagauaaaa augaguuaaa agaaauuugu gaauugaccg gcauugauca aucaguucua      960

gaacgagcau ucaguuuccg aacaguugag gccaaacagg agaaaguuuc aacuacacug     1020

aauguggcuc aggcuuauua ugcccgugau gcucuggcua aaaaccucua cagcagguug     1080

uuuucauggu ugguaaaucg aaucaaugaa agcauuaagg cacaaacaaa agugagaaag     1140

aaggucaugg guguucugga cauuuauggc uuugagauuu ucgaggacaa cagcuuugag     1200

caguucauua uuaauuauug uaacgaaaag cugcaacaaa ucuucauuga acuuacucuu     1260

aaagaagagc aggaggagua uauacgggag gauauagaau ggacucacau ugacuacuuc     1320

aauaaugcua ucauuuguga ccuaauagaa aauaacacaa auggaauccu ggccaugcug     1380

gaugaagagu gccucagacc uggcacaguc acugaugaga ccuucuuaga aaagcugaac     1440

caaguaugug ccacccacca gcauuuugaa agcaggauga gcaagugcuc ucgguuccuc     1500

aaugacacgu cucugccuca cagcugcuuc aggauccagc auuaugcugg aaaggugcug     1560

uaccaggugg aaggauucgu ugacaaaaac aaugaccuuc ucuaucgaga ccugucccaa     1620

gccaugugga aggccagcca ugcccucauc aagucuuugu uccccgaagg gaaucccgcc     1680

aagaucaacc ugaaaaggcc uccuacagca ggcucacagu ucaaggcauc cguggccacu     1740

cugaugaaaa accuacagac caagaaccca aacuauauua gguguaucaa accgaaugau     1800

aaaaaagcag cacacaucuu caacgaggcu cuaguguguc aucagaucag guaccugggg     1860

cuuuuggaga acguccgagu gcggagggca ggcuacgccu ucaggcaggc cuaugaaccu     1920

ugccuagaaa gauacaaaau gcuuuguaaa caaacauggc cucauuggaa aggaccagcc     1980

aggucuggug uggagguccu auuuaaugaa uuagaaauuc ccguggaaga auacuccuuu     2040

gguagaucaa agauauucau ccgaaaccca agaacauuau ucaaauuaga agaccugagg     2100

aagcaacgcc uggaggacuu ggccacucuc auucagaaga uauaucgggg guggaaaugc     2160

cgcacacacu uccugcuaau gaaaaaaagc caaauuguga uugccgccug guacaggaga     2220

uaugcgcaac aaaagaggua ccagcagaca aagaguuccg ccuuaguaau ucagucuuau     2280

auccgggguu ggaaggcucg aaaaauucug cgggaacuga agcaucaaaa gcgcuguaag     2340

gaagcaguca cgaccauugc ugcauauugg caugggaccc aggcacgaag ggaacugaga     2400

cggcugaagg aggaggcuag gaauaaacau gcuauugcag uuauuugggc uuacuggcuu     2460

ggaucuaagg cucgaaggga auugaaacgc uugaaggagg aggcuaggcg uaagcaugca     2520

guugcuguca uuugggcuua cuggcuugga cugaagguac guagagaaua caggaaauuc     2580

uucagagcca augcuggaaa gaaaaucuau gaguuuacgc uucagagaau ugugcaaaaa     2640

uacuucuugg aaaugaaaaa uaagaugccu uccuuaucuc caauagacaa gaauuggccc     2700

ucaagaccuu acuuauucuu ggauucuacu cacaaggagc uaaaaaggau uuuccacuug     2760

uggaggugua aaaaauacag ggaccaauuc acagaccagc agaaacuuau uuaugaagag     2820

aaacuagaag ccagugaacu cuucaaagac aagaaggcuu uauacccauc uaguguuggg     2880

caaccauucc aaggggcuua ccuggaaauc aacaagaacc ccaaguauaa gaaacucaaa     2940

gaugccauug aagaaaagau caucauugcu gaagucguga acaaaauuaa ccgugcuaau     3000

gggaagagua caucucggau uuuccucuua acaaacaaua aucuccuucu ugcugaccaa     3060

aagucuggac aaaucaaguc agagguucca cugguggaug ugaccaaggu aucaaugagc     3120

ucacaaaaug auggcuucuu cgccguccac cucaaagagg gcucagaagc agcuaguaaa     3180

ggagacuuuc ucuucagcag ugaucaccug auugaaaugg ccaccaagcu cuaucgcaca     3240

acucucagcc aaaccaaaca gaagcucaau auugagauuu ccgaugaguu ccugguacag     3300

uucagacagg acaaaguaug ugugaaguuu auucagggaa accagaaaaa ugggaguguc     3360

ccaacaugua aacgaaaaaa caaccgucuc cuugaaguug cugucccuua a              3411


<210>  2801
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1B__Homo_sapiens__AAH53558

<400>  2801
auggccaaga uggaggugaa gaccagccug cucgacaaca ugaucggcgu cggggacaug       60

gugcugcugg agccccucaa cgaggagacc uucaucaaca accugaagaa gcgcuucgac      120

cacuccgaga ucuacacgua caucggcagc guggucaucu ccgugaaccc cuaccggagc      180

cugcccaucu acucccccga gaagguggag gaguaccgca accggaacuu cuacgagcuc      240

agcccccaca ucuucgcccu guccgacgag gcguaccgca gccugcggga ccaggacaag      300

gaccagugca uccucaucac cggggagucc ggcgccggga agaccgaggc cagcaagcug      360

gucauguccu acguggccgc cgugugcggc aagggcgcgg aggucaacca ggugaaggag      420

cagcugcucc agagcaaccc ggugcuggag gccuucggga acgccaagac cguccgcaac      480

gacaacucca gccgguucgg caaguacaug gacaucgagu ucgacuucaa gggggacccc      540

cugggcgggg ugaucuccaa cuaccuccug gagaaguccc gcguggucaa gcagccccgg      600

ggcgagcgca acuuccacgu guucuaccag cugcucagcg gcgccagcga ggagcugcug      660

aacaagcuca agcuggagcg ggacuucucc cgcuacaacu accugagccu cgacagcgcg      720

aaggugaacg gggucgacga cgccgccaac uuccggacgg ugcgcaacgc caugcagauc      780

gugggcuuca uggaccacga ggccgagucc guccuggcgg ugguggccgc cguccugaag      840

cucgggaaca ucgaguucaa gcccgagagc cgggugaacg gccuggacga guccaagauc      900

aaggacaaga acgagcugaa ggagaucugc gagcucaccg gcaucgacca gagcguccug      960

gagcgcgccu ucuccuuccg gaccguggag gccaagcagg agaaggugag caccacgcug     1020

aacgucgcgc aggccuacua cgcccgcgac gcccucgcca agaaccugua cucccggcug     1080

uucagcuggc ucgugaaccg caucaacgag uccaucaagg cgcagaccaa ggugcggaag     1140

aaggucaugg gggugcugga caucuacggc uucgagaucu ucgaggacaa cagcuucgag     1200

caguucauca ucaacuacug caacgagaag cugcagcaga ucuucaucga gcucacccug     1260

aaggaggagc aggaggagua cauccgcgag gacaucgagu ggacccacau cgacuacuuc     1320

aacaacgcca ucaucugcga ccugaucgag aacaacacga acgggauccu cgccaugcug     1380

gacgaggagu gccugcgccc gggcaccgug accgacgaga ccuuccucga gaagcugaac     1440

caggucugcg ccacgcacca gcacuucgag ucccggauga gcaagugcuc ccgcuuccug     1500

aacgacacca gccuccccca cuccugcuuc cggauccagc acuacgccgg gaaggugcug     1560

uaccaggugg agggcuucgu cgacaagaac aacgaccugc uguaccgcga ccucagccag     1620

gcgaugugga aggccuccca cgcccugauc aagagccugu uccccgaggg caaccccgcc     1680

aagaucaacc ucaagcggcc gcccaccgcg gggucccagu ucaaggccag cguggccacc     1740

cugaugaaga accugcagac gaagaacccc aacuacaucc gcugcaucaa gcccaacgac     1800

aagaaggccg cccacaucuu caacgaggcg cucgugugcc accagauccg guaccugggc     1860

cugcucgaga acguccgcgu gcggcgcgcc ggguacgccu uccggcaggc cuacgagccg     1920

ugccuggagc gcuacaagau gcugugcaag cagaccuggc cccacuggaa gggccccgcc     1980

cggagcgggg uggagguccu cuucaacgag cuggagaucc ccguggagga guacuccuuc     2040

ggccgcagca agaucuucau ccggaacccg cgcacccugu ucaagcucga ggaccugcgg     2100

aagcagcgcc uggaggaccu cgcgacccug auccagaaga ucuaccgggg cuggaagugc     2160

cgcacgcacu uccugcucau gaagaagucc cagaucguga ucgccgccug guaccgccgg     2220

uacgcccagc agaagcgcua ccagcagacc aagagcuccg cccuggucau ccagagcuac     2280

auccgggggu ggaaggcgcg caagauccug cgggagcuca agcaccagaa gcgcugcaag     2340

gaggccguga ccaccaucgc cgccuacugg cacggcacgc aggcgcggcg cgagcugcgg     2400

cgccugaagg aggaggcccg gaacaagcac gccaucgccg ugaucugggc cuacuggcuc     2460

ggguccaagg cgcgccggga gcugaagcgc cugaaggagg aggcccggcg caagcacgcc     2520

gucgccguga ucugggccua cuggcucggc cugaaggugc ggcgcgagua ccggaaguuc     2580

uuccgcgcga acgccgggaa gaagaucuac gaguucaccc ugcagcggau cguccagaag     2640

uacuuccucg agaugaagaa caagaugccc agccuguccc ccaucgacaa gaacuggccc     2700

agccgcccgu accuguuccu cgacuccacc cacaaggagc ugaagcgcau cuuccaccug     2760

uggcggugca agaaguaccg cgaccaguuc accgaccagc agaagcucau cuacgaggag     2820

aagcuggagg ccagcgagcu guucaaggac aagaaggccc ucuaccccuc cagcgugggc     2880

cagcccuucc agggcgccua ccuggagauc aacaagaacc ccaaguacaa gaagcugaag     2940

gacgcgaucg aggagaagau caucaucgcc gaggugguca acaagaucaa ccgggccaac     3000

gggaagucca cgagccgcau cuuccuccug accaacaaca accugcuccu ggccgaccag     3060

aaguccggcc agaucaagag cgaggugccg cugguggacg ucaccaaggu gagcaugucc     3120

agccagaacg acggguucuu cgcggugcac cucaaggagg gcuccgaggc cgccagcaag     3180

ggcgacuucc uguucuccag cgaccaccug aucgagaugg ccaccaagcu cuaccggacg     3240

acccuguccc agaccaagca gaagcugaac aucgagauca gcgacgaguu ccucguccag     3300

uuccgccagg acaaggugug cgugaaguuc auccagggga accagaagaa cggcuccguc     3360

ccgaccugca agcggaagaa caaccgccug cuggaggugg ccgugcccug a              3411


<210>  2802
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1B__Homo_sapiens__AAH53558

<400>  2802
auggccaaga uggaggucaa gaccucccuc cucgacaaca ugaucggcgu cggcgacaug       60

guccuccucg agccccucaa cgaggagacc uucaucaaca accucaagaa gcgcuucgac      120

cacuccgaga ucuacaccua caucggcucc gucgucaucu ccgucaaccc cuaccgcucc      180

cuccccaucu acucccccga gaaggucgag gaguaccgca accgcaacuu cuacgagcuc      240

uccccccaca ucuucgcccu cuccgacgag gccuaccgcu cccuccgcga ccaggacaag      300

gaccagugca uccucaucac cggcgagucc ggcgccggca agaccgaggc cuccaagcuc      360

gucauguccu acgucgccgc cgucugcggc aagggcgccg aggucaacca ggucaaggag      420

cagcuccucc aguccaaccc cguccucgag gccuucggca acgccaagac cguccgcaac      480

gacaacuccu cccgcuucgg caaguacaug gacaucgagu ucgacuucaa gggcgacccc      540

cucggcggcg ucaucuccaa cuaccuccuc gagaaguccc gcgucgucaa gcagccccgc      600

ggcgagcgca acuuccacgu cuucuaccag cuccucuccg gcgccuccga ggagcuccuc      660

aacaagcuca agcucgagcg cgacuucucc cgcuacaacu accucucccu cgacuccgcc      720

aaggucaacg gcgucgacga cgccgccaac uuccgcaccg uccgcaacgc caugcagauc      780

gucggcuuca uggaccacga ggccgagucc guccucgccg ucgucgccgc cguccucaag      840

cucggcaaca ucgaguucaa gcccgagucc cgcgucaacg gccucgacga guccaagauc      900

aaggacaaga acgagcucaa ggagaucugc gagcucaccg gcaucgacca guccguccuc      960

gagcgcgccu ucuccuuccg caccgucgag gccaagcagg agaaggucuc caccacccuc     1020

aacgucgccc aggccuacua cgcccgcgac gcccucgcca agaaccucua cucccgccuc     1080

uucuccuggc ucgucaaccg caucaacgag uccaucaagg cccagaccaa gguccgcaag     1140

aaggucaugg gcguccucga caucuacggc uucgagaucu ucgaggacaa cuccuucgag     1200

caguucauca ucaacuacug caacgagaag cuccagcaga ucuucaucga gcucacccuc     1260

aaggaggagc aggaggagua cauccgcgag gacaucgagu ggacccacau cgacuacuuc     1320

aacaacgcca ucaucugcga ccucaucgag aacaacacca acggcauccu cgccaugcuc     1380

gacgaggagu gccuccgccc cggcaccguc accgacgaga ccuuccucga gaagcucaac     1440

caggucugcg ccacccacca gcacuucgag ucccgcaugu ccaagugcuc ccgcuuccuc     1500

aacgacaccu cccuccccca cuccugcuuc cgcauccagc acuacgccgg caagguccuc     1560

uaccaggucg agggcuucgu cgacaagaac aacgaccucc ucuaccgcga ccucucccag     1620

gccaugugga aggccuccca cgcccucauc aagucccucu uccccgaggg caaccccgcc     1680

aagaucaacc ucaagcgccc ccccaccgcc ggcucccagu ucaaggccuc cgucgccacc     1740

cucaugaaga accuccagac caagaacccc aacuacaucc gcugcaucaa gcccaacgac     1800

aagaaggccg cccacaucuu caacgaggcc cucgucugcc accagauccg cuaccucggc     1860

cuccucgaga acguccgcgu ccgccgcgcc ggcuacgccu uccgccaggc cuacgagccc     1920

ugccucgagc gcuacaagau gcucugcaag cagaccuggc cccacuggaa gggccccgcc     1980

cgcuccggcg ucgagguccu cuucaacgag cucgagaucc ccgucgagga guacuccuuc     2040

ggccgcucca agaucuucau ccgcaacccc cgcacccucu ucaagcucga ggaccuccgc     2100

aagcagcgcc ucgaggaccu cgccacccuc auccagaaga ucuaccgcgg cuggaagugc     2160

cgcacccacu uccuccucau gaagaagucc cagaucguca ucgccgccug guaccgccgc     2220

uacgcccagc agaagcgcua ccagcagacc aaguccuccg cccucgucau ccaguccuac     2280

auccgcggcu ggaaggcccg caagauccuc cgcgagcuca agcaccagaa gcgcugcaag     2340

gaggccguca ccaccaucgc cgccuacugg cacggcaccc aggcccgccg cgagcuccgc     2400

cgccucaagg aggaggcccg caacaagcac gccaucgccg ucaucugggc cuacuggcuc     2460

ggcuccaagg cccgccgcga gcucaagcgc cucaaggagg aggcccgccg caagcacgcc     2520

gucgccguca ucugggccua cuggcucggc cucaaggucc gccgcgagua ccgcaaguuc     2580

uuccgcgcca acgccggcaa gaagaucuac gaguucaccc uccagcgcau cguccagaag     2640

uacuuccucg agaugaagaa caagaugccc ucccucuccc ccaucgacaa gaacuggccc     2700

ucccgccccu accucuuccu cgacuccacc cacaaggagc ucaagcgcau cuuccaccuc     2760

uggcgcugca agaaguaccg cgaccaguuc accgaccagc agaagcucau cuacgaggag     2820

aagcucgagg ccuccgagcu cuucaaggac aagaaggccc ucuaccccuc cuccgucggc     2880

cagcccuucc agggcgccua ccucgagauc aacaagaacc ccaaguacaa gaagcucaag     2940

gacgccaucg aggagaagau caucaucgcc gaggucguca acaagaucaa ccgcgccaac     3000

ggcaagucca ccucccgcau cuuccuccuc accaacaaca accuccuccu cgccgaccag     3060

aaguccggcc agaucaaguc cgaggucccc cucgucgacg ucaccaaggu cuccaugucc     3120

ucccagaacg acggcuucuu cgccguccac cucaaggagg gcuccgaggc cgccuccaag     3180

ggcgacuucc ucuucuccuc cgaccaccuc aucgagaugg ccaccaagcu cuaccgcacc     3240

acccucuccc agaccaagca gaagcucaac aucgagaucu ccgacgaguu ccucguccag     3300

uuccgccagg acaaggucug cgucaaguuc auccagggca accagaagaa cggcuccguc     3360

cccaccugca agcgcaagaa caaccgccuc cucgaggucg ccguccccug a              3411


<210>  2803
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1B__Homo_sapiens__AAH53558

<400>  2803
auggccaaga uggaggugaa aaccagccug cucgacaaca ugaucggcgu cggggauaug       60

guucuucugg aacccuugaa ugaggaaaca uucauuaaca auuuaaagaa aagauuugac      120

cacuccgaga uauacacuua uaucggaucu gugguaauuu cagugaaccc uuacaggagu      180

cugccaaucu auagcccgga aaaggucgag gaguaccgga aucgcaacuu cuaugaacua      240

aguccccaua uuuuugcucu cucugaugag gcauaccgau cgcugcguga ccaggauaaa      300

gaccaaugca uccuuauaac gggugaauca ggcgccggga agaccgaggc gagcaagcug      360

gugaugaguu auguugcugc cgugugugga aaaggcgcag aggucaauca ggugaaggaa      420

caguugcucc aguccaaccc uguacuggag gccuucggua augcuaaaac aguuagaaac      480

gauaauucua gcagguuugg gaaguacaug gacaucgagu ucgauuuuaa aggagaccca      540

cugggcggcg ugauuuccaa cuaccucuua gaaaagucac gggucgugaa gcaaccccgc      600

ggggaaagaa auuuccacgu guuuuaucag cugcuuagug gagcaagcga ggaguugcug      660

aacaaacuaa agcucgaaag ggauuucucu cgguacaauu aucugucccu ugacucagcc      720

aaagucaacg guguugauga cgcugccaac uuucgcacug ugcgaaaugc gaugcagauc      780

guaggcuuca uggaccauga ggcagaaagc gugcuggccg ucguggcugc cguuuugaag      840

cucgggaaca uugaguuuaa accugaaagu agagugaaug gacuggauga gucuaagauc      900

aaagacaaga acgaguuaaa ggaaauaugc gagcugaccg gcauugauca guccguccuc      960

gaaagggcau ucagcuuccg gacaguggag gcuaaacaag aaaagguauc gaccacucuu     1020

aauguugccc aggcguacua ugcccgugac gcacuggcua aaaacuugua cucucgccua     1080

uuuuccuggc uggugaauag aaucaacgag ucaauuaagg cccagacaaa agucaggaag     1140

aaggugaugg guguccucga uaucuauggg uucgagaucu uugaagacaa uaguuucgag     1200

caguuuauua uaaacuacug uaaugaaaaa cugcaacaga ucuucauuga gcuuacccug     1260

aaggaggaac aggaggaaua cauccgggag gauauagaau ggacgcacau ugacuauuuu     1320

aacaaugcua ucaucugcga uuugauugag aacaauacua acggaauccu cgccaugcug     1380

gacgaggaau guuuacgacc aggcaccgug acagaugaga cuuuccugga aaaacuaaac     1440

caaguuugcg caacccauca gcacuuugag agccgcaugu ccaaguguuc uagauuccuc     1500

aaugacacaa gccugcccca cucaugcuuu aggauucagc auuacgccgg caaagugcuu     1560

uaucagguag aaggguucgu cgacaagaac aaugauuugc uguaccggga ccucagucaa     1620

gcuaugugga aggcguccca cgcacugaua aaaagccuuu uuccugaggg aaacccagcc     1680

aagaucaauc ugaaacgccc gcccaccgcu gguucucagu ucaaggccuc aguggcaacg     1740

uugaugaaaa accuccagac uaagaauccu aacuauauua gauguaucaa gccaaaugau     1800

aaaaaggccg cucauaucuu caacgaggcc cugguuugcc accagauuag guacuuaggc     1860

cugcuagaaa augugcgugu ccggcgagca ggguaugcgu uuagacaggc uuacgagccc     1920

ugucucgaaa gguacaaaau gcugugcaag caaacauggc cucacuggaa aggaccagcc     1980

cgcaguggcg uggagguacu uuucaacgaa uuggagauac ccguggagga auauagcuuu     2040

ggucggucca agaucuucau uagaaauccg aggacccugu uuaaacucga ggaccugcgc     2100

aagcagcgau uagaagaucu ggcaacucuu auccagaaga uuuaccgggg guggaaaugc     2160

cguacacauu ucuugcucau gaagaaaucu caaaucguua uagccgcuug guauagaagg     2220

uacgcccagc agaagcgcua ucagcaaacc aaaucgagcg cacuggucau ccaguccuac     2280

auucggggcu ggaaggcuag aaagauccua agggagcuga aacaccagaa gcgauguaaa     2340

gaggccguga cgaccauugc ggccuauugg cauggaacac aagcucgccg ggaacucaga     2400

aggcugaagg aggaagcacg uaacaaacac gccaucgcug ugauaugggc cuacuggcuu     2460

ggcucaaagg cacgccggga guugaagaga cugaaagaag aggcgaggcg aaagcaugcc     2520

gucgcuguua uuugggccua cugguuaggg cucaaagugc ggcgcgagua uagaaaguuu     2580

uucagggcaa augcugguaa aaagaucuac gaauuuacuc ugcagcggau ugugcagaag     2640

uauuuccuug agaugaaaaa caagaugccu agucugucuc ccaucgacaa aaacuggcca     2700

agccgaccuu acuuguuucu cgauuccacc cacaaggaac ugaaaagaau auuccaccua     2760

uggcgcugca agaaauauag ggaccaguuu acagaucaac agaagcugau cuacgaggaa     2820

aagcucgagg ccucagagcu guucaaagac aagaaagcac uuuaucccag cucuguagga     2880

cagccauucc agggcgccua cuuggaaauu aauaagaacc ccaaauacaa gaagcugaaa     2940

gaugcuaucg aggaaaagau uaucauagcg gaggucguga auaaaauuaa ccgugccaau     3000

gggaagucca cuucccggau cuuuuuacuc accaacaaua accugcuucu ggcagaccag     3060

aaaagcggac aaaucaaguc ugaaguuccu cuaguggaug ucacaaaggu guccauguca     3120

agucagaaug acggcuucuu ugcuguucau cucaaagagg guagcgaggc cgccucgaag     3180

ggggacuucc uguuuuccuc ugaucacuug auugaaaugg cuaccaaacu guauagaacu     3240

acguuaagcc agacaaagca aaaacucaac aucgagauuu cagacgaguu ccuggugcag     3300

uuuaggcagg auaagguaug ugucaaguuc auacaaggca aucagaaaaa cggaagugug     3360

ccaaccugca agcgcaaaaa uaaccgacuu cuggaagugg cagucccgug a              3411


<210>  2804
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1B__Homo_sapiens__AAH53558

<400>  2804
auggccaaga uggaggugaa gaccagccug cuggacaaca ugaucggcgu gggcgacaug       60

gugcugcugg agccccugaa cgaggagacc uucaucaaca accugaagaa gagauucgac      120

cacagcgaga ucuacaccua caucggcagc guggugauca gcgugaaccc cuacagaagc      180

cugcccaucu acagccccga gaagguggag gaguacagaa acagaaacuu cuacgagcug      240

agcccccaca ucuucgcccu gagcgacgag gccuacagaa gccugagaga ccaggacaag      300

gaccagugca uccugaucac cggcgagagc ggcgccggca agaccgaggc cagcaagcug      360

gugaugagcu acguggccgc cgugugcggc aagggcgccg aggugaacca ggugaaggag      420

cagcugcugc agagcaaccc cgugcuggag gccuucggca acgccaagac cgugagaaac      480

gacaacagca gcagauucgg caaguacaug gacaucgagu ucgacuucaa gggcgacccc      540

cugggcggcg ugaucagcaa cuaccugcug gagaagagca gaguggugaa gcagcccaga      600

ggcgagagaa acuuccacgu guucuaccag cugcugagcg gcgccagcga ggagcugcug      660

aacaagcuga agcuggagag agacuucagc agauacaacu accugagccu ggacagcgcc      720

aaggugaacg gcguggacga cgccgccaac uucagaaccg ugagaaacgc caugcagauc      780

gugggcuuca uggaccacga ggccgagagc gugcuggccg ugguggccgc cgugcugaag      840

cugggcaaca ucgaguucaa gcccgagagc agagugaacg gccuggacga gagcaagauc      900

aaggacaaga acgagcugaa ggagaucugc gagcugaccg gcaucgacca gagcgugcug      960

gagagagccu ucagcuucag aaccguggag gccaagcagg agaaggugag caccacccug     1020

aacguggccc aggccuacua cgccagagac gcccuggcca agaaccugua cagcagacug     1080

uucagcuggc uggugaacag aaucaacgag agcaucaagg cccagaccaa ggugagaaag     1140

aaggugaugg gcgugcugga caucuacggc uucgagaucu ucgaggacaa cagcuucgag     1200

caguucauca ucaacuacug caacgagaag cugcagcaga ucuucaucga gcugacccug     1260

aaggaggagc aggaggagua caucagagag gacaucgagu ggacccacau cgacuacuuc     1320

aacaacgcca ucaucugcga ccugaucgag aacaacacca acggcauccu ggccaugcug     1380

gacgaggagu gccugagacc cggcaccgug accgacgaga ccuuccugga gaagcugaac     1440

caggugugcg ccacccacca gcacuucgag agcagaauga gcaagugcag cagauuccug     1500

aacgacacca gccugcccca cagcugcuuc agaauccagc acuacgccgg caaggugcug     1560

uaccaggugg agggcuucgu ggacaagaac aacgaccugc uguacagaga ccugagccag     1620

gccaugugga aggccagcca cgcccugauc aagagccugu uccccgaggg caaccccgcc     1680

aagaucaacc ugaagagacc ccccaccgcc ggcagccagu ucaaggccag cguggccacc     1740

cugaugaaga accugcagac caagaacccc aacuacauca gaugcaucaa gcccaacgac     1800

aagaaggccg cccacaucuu caacgaggcc cuggugugcc accagaucag auaccugggc     1860

cugcuggaga acgugagagu gagaagagcc ggcuacgccu ucagacaggc cuacgagccc     1920

ugccuggaga gauacaagau gcugugcaag cagaccuggc cccacuggaa gggccccgcc     1980

agaagcggcg uggaggugcu guucaacgag cuggagaucc ccguggagga guacagcuuc     2040

ggcagaagca agaucuucau cagaaacccc agaacccugu ucaagcugga ggaccugaga     2100

aagcagagac uggaggaccu ggccacccug auccagaaga ucuacagagg cuggaagugc     2160

agaacccacu uccugcugau gaagaagagc cagaucguga ucgccgccug guacagaaga     2220

uacgcccagc agaagagaua ccagcagacc aagagcagcg cccuggugau ccagagcuac     2280

aucagaggcu ggaaggccag aaagauccug agagagcuga agcaccagaa gagaugcaag     2340

gaggccguga ccaccaucgc cgccuacugg cacggcaccc aggccagaag agagcugaga     2400

agacugaagg aggaggccag aaacaagcac gccaucgccg ugaucugggc cuacuggcug     2460

ggcagcaagg ccagaagaga gcugaagaga cugaaggagg aggccagaag aaagcacgcc     2520

guggccguga ucugggccua cuggcugggc cugaagguga gaagagagua cagaaaguuc     2580

uucagagcca acgccggcaa gaagaucuac gaguucaccc ugcagagaau cgugcagaag     2640

uacuuccugg agaugaagaa caagaugccc agccugagcc ccaucgacaa gaacuggccc     2700

agcagacccu accuguuccu ggacagcacc cacaaggagc ugaagagaau cuuccaccug     2760

uggagaugca agaaguacag agaccaguuc accgaccagc agaagcugau cuacgaggag     2820

aagcuggagg ccagcgagcu guucaaggac aagaaggccc uguaccccag cagcgugggc     2880

cagcccuucc agggcgccua ccuggagauc aacaagaacc ccaaguacaa gaagcugaag     2940

gacgccaucg aggagaagau caucaucgcc gaggugguga acaagaucaa cagagccaac     3000

ggcaagagca ccagcagaau cuuccugcug accaacaaca accugcugcu ggccgaccag     3060

aagagcggcc agaucaagag cgaggugccc cugguggacg ugaccaaggu gagcaugagc     3120

agccagaacg acggcuucuu cgccgugcac cugaaggagg gcagcgaggc cgccagcaag     3180

ggcgacuucc uguucagcag cgaccaccug aucgagaugg ccaccaagcu guacagaacc     3240

acccugagcc agaccaagca gaagcugaac aucgagauca gcgacgaguu ccuggugcag     3300

uucagacagg acaaggugug cgugaaguuc auccagggca accagaagaa cggcagcgug     3360

cccaccugca agagaaagaa caacagacug cuggaggugg ccgugcccug a              3411


<210>  2805
<211>  3411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1B__Homo_sapiens__AAH53558

<400>  2805
auggccaaga uggaggugaa aaccagccug cucgacaaca ugaucggcgu cggggauaug       60

guucugcuug aaccccugaa ugaggaaaca uucauuaaca aucucaagaa aagauuugac      120

cacuccgaga ucuacacgua uauuggaucu guggugauca gcgucaaccc uuaccggucc      180

cugccgauuu auucucccga aaagguggag gaguaccgca auagaaacuu cuaugaacuu      240

agcccucaua ucuuugcucu guccgaugag gccuaccggu cucuccgcga ccaggauaaa      300

gaccaaugca uccugauuac cggcgaaagc ggggcgggaa agacagaggc uuccaagcug      360

guuaugagcu auguggccgc cgucuguggc aaaggggcug aggugaauca gguuaaggaa      420

cagcuccugc agucuaaccc cgugcuugag gccuucggaa augcuaaaac cgucagaaac      480

gauaauucca gccgguuugg caaguacaug gacaucgaau uugauuuuaa aggcgacccu      540

cuugggggag ugauuucuaa cuaccuccug gagaaguccc gcguggucaa gcaacccaga      600

ggcgaacgga auuuccacgu uuucuaucag cuucugagcg gggccucuga ggagcuccug      660

aacaaacuga agcucgaacg cgauuucucc agauacaauu aucugagccu ugacuccgcg      720

aaagugaacg gaguggauga cgccgcuaac uuucggacag uccgcaaugc caugcagauc      780

gugggcuuca uggaccauga ggcugaaucu guucuggccg uggucgcggc cgugcucaag      840

cuggggaaca uugaguuuaa accugaaagc agaguuaaug gacuugauga guccaagauc      900

aaagacaaga acgagcugaa ggaaauuugc gagcucaccg gcaucgauca gagcgugcug      960

gaacgggcuu ucucuuuccg cacagucgag gccaaacaag aaaagguguc caccacgcug     1020

aaugucgcuc aggccuacua ugccagagac gcucucgcga aaaaccugua cagccggcug     1080

uuuucuuggc uggugaauag aaucaacgag agcauuaagg cccagaccaa aguucgcaag     1140

aaggugaugg gcguccucga uaucuauggg uucgagauuu uugaagacaa uuccuucgag     1200

caguuuauca uuaacuacug uaaugaaaaa cugcaacaga ucuucaucga gcuuacacug     1260

aaggaggaac aggaggaaua cauucgggag gauaucgaau ggacccacau ugacuauuuu     1320

aacaaugcua ucauuugcga ucucaucgag aacaauacaa acggaauccu ggccaugcug     1380

gacgaggaau gucucagacc gggcaccgug acggaugaga cauuccugga aaaacuuaac     1440

caaguuugcg ccacccauca gcacuuugag ucucgcauga gcaaguguuc ccgguuccug     1500

aaugacacaa gccuccccca cucuugcuuu cgcauucagc auuacgcugg gaaagugcug     1560

uaucaggucg aaggauucgu ggacaagaac aaugaucugc uuuacagaga ccucucccaa     1620

gccaugugga aggcgagcca cgcucugauc aaaucucugu uuccugaggg caaccccgcc     1680

aagauuaauc ucaaacggcc ucccaccgcc gggucccagu ucaaggcuag cguggccacc     1740

cugaugaaaa accuucagac aaagaauccg aacuauauca gauguauuaa gccuaaugau     1800

aaaaaggcug cccauaucuu caacgaggcg cugguuugcc accagauucg cuaccucgga     1860

cugcuggaaa auguccgggu gagacgcgcc ggcuaugcuu uucggcaagc cuacgagccc     1920

ugucuugaaa gauacaaaau gcucugcaag cagacguggc cucacuggaa aggccccgcu     1980

cgguccgggg uggagguccu guucaacgaa cuggagaucc ccguggagga auauucuuuu     2040

ggacgcagca agaucuucau uagaaauccu cggacccucu uuaaacugga ggaccuuaga     2100

aagcagcgcc uggaagaucu cgccacacug auccagaaga uuuaccgggg cuggaaaugc     2160

agaacccauu uccugcuuau gaagaaaucc caaaucguua uugcggccug guaucgcaga     2220

uacgcucagc agaagcggua ucagcaaaca aaaucuagcg cccucgugau ccaguccuac     2280

auccgcgggu ggaaggcuag aaagauucug cgggagcuga aacaccagaa gcgcuguaaa     2340

gaggccguca ccacgaucgc cgcuuauugg cauggaacac aagcgagacg ggaacuccgc     2400

agacugaagg aggaagcccg gaacaaacac gcuauugccg ugaucugggc cuacuggcuu     2460

ggcagcaagg cucgcagaga gcugaagcgg cucaaagaag aggccagacg caagcaugcg     2520

guugcuguga uuugggccua cuggcugggg cugaaagucc ggagagagua ucgcaaguuu     2580

uuccgggcca augcuggcaa aaagaucuac gaauuuaccc uucagagaau cgugcagaag     2640

uauuuccucg agaugaaaaa caagaugccg ucucuguccc ccauugacaa aaacuggccu     2700

agccgccccu accuguuucu cgauucuacc cacaaggaac ugaaacggau cuuccaccuu     2760

uggagaugca agaaauaucg cgaccaguuu acagaucaac agaagcugau uuacgaggaa     2820

aagcucgagg ccuccgagcu guucaaagac aagaaagcgc uguauccuag cucuguugga     2880

cagcccuucc agggcgcuua ccuugaaauc aauaagaacc cgaaauacaa gaagcugaaa     2940

gaugccauug aggaaaagau caucauugcc gaggugguca auaaaaucaa ccgggcuaau     3000

ggaaagagca ccuccagaau uuuucuccug acaaacaaua accuccugcu ugccgaccag     3060

aaaagcgggc aaaucaaguc ugaagugccu cugguggaug ucacgaaggu uuccaugagc     3120

ucccagaaug acggcuucuu ugcugugcau cucaaagagg ggucugaggc cgcgagcaag     3180

ggagacuucc uguuuuccuc ugaucaccug auugaaaugg ccaccaaacu uuaucggaca     3240

acccugagcc agacaaagca aaaacucaac aucgagauuu ccgacgaguu ccuggugcag     3300

uuucgccagg auaaggucug ugugaaguuc auccaaggca aucagaaaaa cgggucuguu     3360

ccuaccugca agcggaaaaa uaacagacuc cuggaagugg cuguccccug a              3411


<210>  2806
<211>  1063
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1C__Homo_sapiens__O00159

<400>  2806

Met Ala Leu Gln Val Glu Leu Val Pro Thr Gly Glu Ile Ile Arg Val 
1               5                   10                  15      


Val His Pro His Arg Pro Cys Lys Leu Ala Leu Gly Ser Asp Gly Val 
            20                  25                  30          


Arg Val Thr Met Glu Ser Ala Leu Thr Ala Arg Asp Arg Val Gly Val 
        35                  40                  45              


Gln Asp Phe Val Leu Leu Glu Asn Phe Thr Ser Glu Ala Ala Phe Ile 
    50                  55                  60                  


Glu Asn Leu Arg Arg Arg Phe Arg Glu Asn Leu Ile Tyr Thr Tyr Ile 
65                  70                  75                  80  


Gly Pro Val Leu Val Ser Val Asn Pro Tyr Arg Asp Leu Gln Ile Tyr 
                85                  90                  95      


Ser Arg Gln His Met Glu Arg Tyr Arg Gly Val Ser Phe Tyr Glu Val 
            100                 105                 110         


Pro Pro His Leu Phe Ala Val Ala Asp Thr Val Tyr Arg Ala Leu Arg 
        115                 120                 125             


Thr Glu Arg Arg Asp Gln Ala Val Met Ile Ser Gly Glu Ser Gly Ala 
    130                 135                 140                 


Gly Lys Thr Glu Ala Thr Lys Arg Leu Leu Gln Phe Tyr Ala Glu Thr 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Arg Gly Gly Ala Val Arg Asp Arg Leu Leu Gln 
                165                 170                 175     


Ser Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn 
            180                 185                 190         


Asp Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp Val Gln Phe Asp Phe 
        195                 200                 205             


Lys Gly Ala Pro Val Gly Gly His Ile Leu Ser Tyr Leu Leu Glu Lys 
    210                 215                 220                 


Ser Arg Val Val His Gln Asn His Gly Glu Arg Asn Phe His Ile Phe 
225                 230                 235                 240 


Tyr Gln Leu Leu Glu Gly Gly Glu Glu Glu Thr Leu Arg Arg Leu Gly 
                245                 250                 255     


Leu Glu Arg Asn Pro Gln Ser Tyr Leu Tyr Leu Val Lys Gly Gln Cys 
            260                 265                 270         


Ala Lys Val Ser Ser Ile Asn Asp Lys Ser Asp Trp Lys Val Val Arg 
        275                 280                 285             


Lys Ala Leu Thr Val Ile Asp Phe Thr Glu Asp Glu Val Glu Asp Leu 
    290                 295                 300                 


Leu Ser Ile Val Ala Ser Val Leu His Leu Gly Asn Ile His Phe Ala 
305                 310                 315                 320 


Ala Asn Glu Glu Ser Asn Ala Gln Val Thr Thr Glu Asn Gln Leu Lys 
                325                 330                 335     


Tyr Leu Thr Arg Leu Leu Ser Val Glu Gly Ser Thr Leu Arg Glu Ala 
            340                 345                 350         


Leu Thr His Arg Lys Ile Ile Ala Lys Gly Glu Glu Leu Leu Ser Pro 
        355                 360                 365             


Leu Asn Leu Glu Gln Ala Ala Tyr Ala Arg Asp Ala Leu Ala Lys Ala 
    370                 375                 380                 


Val Tyr Ser Arg Thr Phe Thr Trp Leu Val Gly Lys Ile Asn Arg Ser 
385                 390                 395                 400 


Leu Ala Ser Lys Asp Val Glu Ser Pro Ser Trp Arg Ser Thr Thr Val 
                405                 410                 415     


Leu Gly Leu Leu Asp Ile Tyr Gly Phe Glu Val Phe Gln His Asn Ser 
            420                 425                 430         


Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu 
        435                 440                 445             


Phe Ile Glu Leu Thr Leu Lys Ser Glu Gln Glu Glu Tyr Glu Ala Glu 
    450                 455                 460                 


Gly Ile Ala Trp Glu Pro Val Gln Tyr Phe Asn Asn Lys Ile Ile Cys 
465                 470                 475                 480 


Asp Leu Val Glu Glu Lys Phe Lys Gly Ile Ile Ser Ile Leu Asp Glu 
                485                 490                 495     


Glu Cys Leu Arg Pro Gly Glu Ala Thr Asp Leu Thr Phe Leu Glu Lys 
            500                 505                 510         


Leu Glu Asp Thr Val Lys His His Pro His Phe Leu Thr His Lys Leu 
        515                 520                 525             


Ala Asp Gln Arg Thr Arg Lys Ser Leu Gly Arg Gly Glu Phe Arg Leu 
    530                 535                 540                 


Leu His Tyr Ala Gly Glu Val Thr Tyr Ser Val Thr Gly Phe Leu Asp 
545                 550                 555                 560 


Lys Asn Asn Asp Leu Leu Phe Arg Asn Leu Lys Glu Thr Met Cys Ser 
                565                 570                 575     


Ser Lys Asn Pro Ile Met Ser Gln Cys Phe Asp Arg Ser Glu Leu Ser 
            580                 585                 590         


Asp Lys Lys Arg Pro Glu Thr Val Ala Thr Gln Phe Lys Met Ser Leu 
        595                 600                 605             


Leu Gln Leu Val Glu Ile Leu Gln Ser Lys Glu Pro Ala Tyr Val Arg 
    610                 615                 620                 


Cys Ile Lys Pro Asn Asp Ala Lys Gln Pro Gly Arg Phe Asp Glu Val 
625                 630                 635                 640 


Leu Ile Arg His Gln Val Lys Tyr Leu Gly Leu Leu Glu Asn Leu Arg 
                645                 650                 655     


Val Arg Arg Ala Gly Phe Ala Tyr Arg Arg Lys Tyr Glu Ala Phe Leu 
            660                 665                 670         


Gln Arg Tyr Lys Ser Leu Cys Pro Glu Thr Trp Pro Thr Trp Ala Gly 
        675                 680                 685             


Arg Pro Gln Asp Gly Val Ala Val Leu Val Arg His Leu Gly Tyr Lys 
    690                 695                 700                 


Pro Glu Glu Tyr Lys Met Gly Arg Thr Lys Ile Phe Ile Arg Phe Pro 
705                 710                 715                 720 


Lys Thr Leu Phe Ala Thr Glu Asp Ala Leu Glu Val Arg Arg Gln Ser 
                725                 730                 735     


Leu Ala Thr Lys Ile Gln Ala Ala Trp Arg Gly Phe His Trp Arg Gln 
            740                 745                 750         


Lys Phe Leu Arg Val Lys Arg Ser Ala Ile Cys Ile Gln Ser Trp Trp 
        755                 760                 765             


Arg Gly Thr Leu Gly Arg Arg Lys Ala Ala Lys Arg Lys Trp Ala Ala 
    770                 775                 780                 


Gln Thr Ile Arg Arg Leu Ile Arg Gly Phe Val Leu Arg His Ala Pro 
785                 790                 795                 800 


Arg Cys Pro Glu Asn Ala Phe Phe Leu Asp His Val Arg Thr Ser Phe 
                805                 810                 815     


Leu Leu Asn Leu Arg Arg Gln Leu Pro Gln Asn Val Leu Asp Thr Ser 
            820                 825                 830         


Trp Pro Thr Pro Pro Pro Ala Leu Arg Glu Ala Ser Glu Leu Leu Arg 
        835                 840                 845             


Glu Leu Cys Ile Lys Asn Met Val Trp Lys Tyr Cys Arg Ser Ile Ser 
    850                 855                 860                 


Pro Glu Trp Lys Gln Gln Leu Gln Gln Lys Ala Val Ala Ser Glu Ile 
865                 870                 875                 880 


Phe Lys Gly Lys Lys Asp Asn Tyr Pro Gln Ser Val Pro Arg Leu Phe 
                885                 890                 895     


Ile Ser Thr Arg Leu Gly Thr Asp Glu Ile Ser Pro Arg Val Leu Gln 
            900                 905                 910         


Ala Leu Gly Ser Glu Pro Ile Gln Tyr Ala Val Pro Val Val Lys Tyr 
        915                 920                 925             


Asp Arg Lys Gly Tyr Lys Pro Arg Ser Arg Gln Leu Leu Leu Thr Pro 
    930                 935                 940                 


Asn Ala Val Val Ile Val Glu Asp Ala Lys Val Lys Gln Arg Ile Asp 
945                 950                 955                 960 


Tyr Ala Asn Leu Thr Gly Ile Ser Val Ser Ser Leu Ser Asp Ser Leu 
                965                 970                 975     


Phe Val Leu His Val Gln Arg Ala Asp Asn Lys Gln Lys Gly Asp Val 
            980                 985                 990         


Val Leu Gln Ser Asp His Val Ile Glu Thr Leu Thr Lys Thr Ala Leu 
        995                 1000                1005            


Ser Ala Asn Arg Val Asn Ser Ile Asn Ile Asn Gln Gly Ser Ile Thr 
    1010                1015                1020                


Phe Ala Gly Gly Pro Gly Arg Asp Gly Thr Ile Asp Phe Thr Pro Gly 
1025                1030                1035                1040


Ser Glu Leu Leu Ile Thr Lys Ala Lys Asn Gly His Leu Ala Val Val 
                1045                1050                1055    


Ala Pro Arg Leu Asn Ser Arg 
            1060            


<210>  2807
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1C__Homo_sapiens__CCDS42226.1

<400>  2807
auggcgcugc aaguggagcu gguacccacc ggggagauca uccgcguggu ucauccccac       60

aggcccugca agcuugcccu gggcagugac gggguucggg ugaccaugga gagugcgcuc      120

accgcccgug accggguggg ggugcaggau uucgugcugc uggagaacuu caccagcgag      180

gccgccuuca ucgagaaccu gcggcggcga uuucgggaga aucucaucua caccuacauu      240

ggccccgucc uggucucugu caaucccuac cgggaccugc agaucuacag ccggcagcau      300

auggagcguu accguggcgu cagcuucuau gaagugcccc cucaccuguu ugccguggcg      360

gacacugugu accgagcacu gcgcacggag cgucgggacc aggcugugau gaucucuggg      420

gagagcgggg caggcaagac cgaggccacc aagaggcugc ugcaguucua ugcagagacc      480

ugcccagccc ccgagcgcgg aggugccgug cgggaccggc ugcuacagag caacccggug      540

cuggaggccu uuggaaaugc caagacccuc cggaacgaua acuccagcag guucgggaag      600

uacauggaug ugcaguuuga cuucaagggu gcccccgugg guggccacau ccucaguuac      660

cuccuggaaa agucacgagu ggugcaccag aaucaugggg agcggaacuu ccacaucuuc      720

uaccagcugc uggagggggg cgaggaggag acucuucgca ggcugggcuu ggaacggaac      780

ccccagagcu accuguaccu ggugaagggc cagugugcca aagucuccuc caucaacgac      840

aagagugacu ggaaggucgu caggaaggcu cugacaguca uugauuucac cgaggaugaa      900

guggaggacc ugcugagcau cguggccagc guccuucauu ugggcaacau ccacuuugcu      960

gccaacgagg agagcaaugc ccaggucacc accgagaacc agcucaagua ucugaccagg     1020

cuccucagcg uggaaggcuc gacgcugcga gaagcccuga cacacaggaa gaucaucgcc     1080

aagggggagg agcuccugag cccgcugaac cuggagcagg ccgcguacgc acgagacgcc     1140

cucgccaagg cuguguacag ccgcacuuuu accuggcucg ucgggaagau caacaggucg     1200

cuggccucca aggacgugga gagccccagc uggcggagca ccacgguucu cgggcuccug     1260

gauauuuaug gcuuugaagu guuucagcau aacagcuuug agcaguucug caucaauuac     1320

ugcaacgaga agcugcagca gcucuucauc gagcucacgc ucaagucgga gcaggaggag     1380

uacgaggcag agggcaucgc gugggagccc guccaguauu ucaacaacaa aaucaucugu     1440

gaucuggugg aggagaaguu uaagggcauc aucucgauuu uggaugagga gugucugcgc     1500

cccggggagg ccacagaccu gaccuuccug gagaagcugg aggauacugu caagcaccau     1560

ccacacuucc ugacgcacaa gcuggcugac cagcggacca ggaaaucucu gggccgaggg     1620

gaauuccgcc uucugcacua ugcgggggag gugaccuaca gcgugaccgg guuucuggac     1680

aaaaacaaug accuucucuu ccggaaccuu aaggagacca uguguagcuc aaagaauccc     1740

auuaugagcc agugcuuuga ccggagcgag cucagugaca agaagcggcc agagacgguc     1800

gccacccagu ucaagaugag ccuccugcag cugguggaga uccugcaguc uaaggagccc     1860

gccuacgucc gcugcaucaa acccaaugau gccaaacagc ccggccgcuu ugacgaggug     1920

cugauccgcc accaggugaa guaccugggg cuguuggaaa accugcgcgu gcgcagagcc     1980

ggcuuugccu aucgccgcaa auacgaagcu uuccugcaaa gguacaaguc acugugccca     2040

gagacguggc ccacgugggc aggacggccg caggaugggg uggcugugcu gguccgacac     2100

cugggcuaca agccagaaga guacaagaug ggcaggacca agaucuucau ccgcuucccc     2160

aagacccugu uugccacaga ggaugcccug gagguccggc ggcagagccu ggccacaaag     2220

auccaagcug ccuggagggg cuuucacugg cggcagaaau uccuccgggu gaagagauca     2280

gccaucugca uccagucgug guggcgugga acacugggcc ggaggaaggc agccaagagg     2340

aagugggcgg cacagaccau ccggcggcuc auccgaggcu ucguccugcg ccacgccccc     2400

cgcugccccg agaacgccuu cuuccuggac caugugcgca ccucuuuuuu gcuaaaccug     2460

aggcggcagc ugccccagaa uguccuggac accucguggc ccacgccccc accugcccug     2520

cgugaggccu cagagcuucu gcgggaguug ugcauaaaga acauggugug gaaauacugc     2580

cggaguauca gcccugagug gaagcagcag cugcagcaga aggccguggc uagugagauc     2640

uucaagggca agaaggauaa uuacccucag aguguaccca ggcucuucau cagcacucgg     2700

cuugguacag augagaucag cccccgagug cugcaggccu ugggcucuga gcccauucag     2760

uaugcggugc cuguugugaa auacgaccgc aagggcuaca agccucgcuc ccggcagcug     2820

cugcucacgc ccaacgccgu cgucaucgug gaggacgcca aagucaagca gaggauugau     2880

uacgccaacc ugaccggaau cucugucagc agccugagcg acagucuuuu ugugcuucau     2940

guacagcgug cggacaauaa gcaaaaggga gauguggugc ugcagaguga ccacgugauu     3000

gagacgcuga ccaagacagc ccucagugcc aaccgcguga acagcaucaa caucaaccag     3060

ggcagcauca cguuugcagg gggccccggc agggauggca ccauugacuu cacacccggc     3120

ucggagcugc ucaucaccaa ggccaagaac gggcaccugg cuguggucgc cccacggcug     3180

aauucucggu ga                                                         3192


<210>  2808
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1C__Homo_sapiens__CCDS42226.1

<400>  2808
auggcccucc agguggagcu cguccccacc ggcgagauca uccgcguggu gcacccgcac       60

cggcccugca agcuggcccu ggggagcgac ggcguccgcg ugaccaugga guccgcgcuc      120

acggcccggg accgcguggg gguccaggac uucgugcugc uggagaacuu caccagcgag      180

gccgccuuca ucgagaaccu ccggcgccgg uuccgcgaga accugaucua caccuacauc      240

ggccccgugc uggucuccgu gaaccccuac cgggaccucc agaucuacag ccgccagcac      300

auggagcggu accgcggggu guccuucuac gaggucccgc cccaccuguu cgccguggcg      360

gacaccgugu accgggcccu gcgcacggag cggcgcgacc aggccgucau gaucagcggc      420

gaguccggcg ccgggaagac cgaggcgacc aagcggcucc ugcaguucua cgccgagacc      480

ugccccgccc ccgagcgcgg cggggccgug cgggaccgcc ugcuccagag caacccggug      540

cuggaggccu ucggcaacgc gaagacgcug cggaacgaca acuccagccg cuucgggaag      600

uacauggacg uccaguucga cuucaagggc gcccccgugg gcgggcacau ccucuccuac      660

cugcuggaga agucccgcgu gguccaccag aaccacggcg agcggaacuu ccacaucuuc      720

uaccagcucc uggagggcgg ggaggaggag acccugcgcc ggcucggccu ggagcgcaac      780

ccccaguccu accuguaccu cgugaagggg cagugcgcca aggugagcuc caucaacgac      840

aagagcgacu ggaaggucgu gcggaaggcc cugaccguca ucgacuucac cgaggacgag      900

guggaggacc ugcucuccau cguggccagc guccugcacc ugggcaacau ccacuucgcg      960

gccaacgagg aguccaacgc ccaggugacg accgagaacc agcucaagua ccugacccgc     1020

cugcucagcg uggaggggag cacccugcgg gaggcccuga cgcaccgcaa gaucaucgcc     1080

aagggcgagg agcuccugag cccccugaac cucgagcagg cggccuacgc ccgggacgcc     1140

cuggccaagg cggucuacag ccgcaccuuc accuggcugg uggggaagau caaccggucc     1200

cucgccagca aggacgugga guccccgagc uggcgcucca ccacgguccu gggccugcuc     1260

gacaucuacg gcuucgaggu guuccagcac aacagcuucg agcaguucug caucaacuac     1320

ugcaacgaga agcugcagca gcuguucauc gagcugaccc ucaaguccga gcaggaggag     1380

uacgaggccg aggggaucgc cugggagccc gugcaguacu ucaacaacaa gaucaucugc     1440

gaccuggucg aggagaaguu caagggcauc aucagcaucc uggacgagga gugccuccgg     1500

cccggggagg cgaccgaccu gaccuuccug gagaagcucg aggacacggu gaagcaccac     1560

ccccacuucc ugacccacaa gcuggccgac cagcgcaccc ggaagucccu cggccgcggg     1620

gaguuccggc ugcugcacua cgccggcgag gugaccuaca gcgucacggg cuuccucgac     1680

aagaacaacg accugcuguu ccgcaaccuc aaggagacca ugugcuccag caagaacccg     1740

aucauguccc agugcuucga ccggagcgag cuguccgaca agaagcgccc cgagaccgug     1800

gccacccagu ucaagaugag ccugcuccag cugguggaga uccugcaguc caaggagccc     1860

gccuacgucc gcugcaucaa gcccaacgac gcgaagcagc cggggcgguu cgacgaggug     1920

cucauccgcc accaggugaa guaccugggc cugcucgaga accugcgggu ccgccgggcc     1980

ggguucgccu accgccggaa guacgaggcc uuccugcagc gcuacaagag ccucugcccc     2040

gagacguggc ccaccugggc cggccggccc caggacgggg uggcggugcu gguccgccac     2100

cugggcuaca agccggagga guacaagaug ggccggacca agaucuucau ccgcuucccc     2160

aagacccucu ucgccacgga ggacgcccug gaggugcggc gccagagccu ggccaccaag     2220

auccaggccg cguggcgggg guuccacugg cgccagaagu uccuccgggu gaagcgcucc     2280

gccaucugca uccagagcug guggcggggc acccuggggc gccggaaggc cgccaagcgc     2340

aagugggcgg cccagaccau ccgccggcug auccgcggcu ucguccuccg gcacgcgccc     2400

cgcugccccg agaacgccuu cuuccuggac cacgugcgga ccuccuuccu gcucaaccug     2460

cgccggcagc ugccgcagaa cgugcucgac acgagcuggc ccacgccccc gcccgcccug     2520

cgcgaggccu ccgagcugcu ccgggagcug ugcaucaaga acauggucug gaaguacugc     2580

cgcagcaucu cccccgagug gaagcagcag cugcagcaga aggccguggc cagcgagauc     2640

uucaagggca agaaggacaa cuacccccag uccgugccgc ggcuguucau cagcacccgc     2700

cuggggaccg acgagaucag cccccggguc cugcaggccc ucggcuccga gcccauccag     2760

uacgccgugc ccguggucaa guacgaccgc aagggguaca agccgcgguc ccgccagcug     2820

cugcucaccc ccaacgcggu ggugaucguc gaggacgcca aggugaagca gcggaucgac     2880

uacgccaacc ugaccggcau cagcgugucc agccuguccg acagccucuu cguccugcac     2940

gugcagcgcg ccgacaacaa gcagaagggg gacguggucc ugcagagcga ccacgugauc     3000

gagacccuca ccaagacggc ccuguccgcg aaccggguga acagcaucaa caucaaccag     3060

ggcuccauca ccuucgccgg cgggcccggc cgcgacggga ccaucgacuu cacccccggc     3120

agcgagcugc ucaucacgaa ggccaagaac gggcaccugg ccgucguggc gccgcgccug     3180

aacucccggu ga                                                         3192


<210>  2809
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1C__Homo_sapiens__CCDS42226.1

<400>  2809
auggcccucc aggucgagcu cguccccacc ggcgagauca uccgcgucgu ccacccccac       60

cgccccugca agcucgcccu cggcuccgac ggcguccgcg ucaccaugga guccgcccuc      120

accgcccgcg accgcgucgg cguccaggac uucguccucc ucgagaacuu caccuccgag      180

gccgccuuca ucgagaaccu ccgccgccgc uuccgcgaga accucaucua caccuacauc      240

ggccccgucc ucgucuccgu caaccccuac cgcgaccucc agaucuacuc ccgccagcac      300

auggagcgcu accgcggcgu cuccuucuac gagguccccc cccaccucuu cgccgucgcc      360

gacaccgucu accgcgcccu ccgcaccgag cgccgcgacc aggccgucau gaucuccggc      420

gaguccggcg ccggcaagac cgaggccacc aagcgccucc uccaguucua cgccgagacc      480

ugccccgccc ccgagcgcgg cggcgccguc cgcgaccgcc uccuccaguc caaccccguc      540

cucgaggccu ucggcaacgc caagacccuc cgcaacgaca acuccucccg cuucggcaag      600

uacauggacg uccaguucga cuucaagggc gcccccgucg gcggccacau ccucuccuac      660

cuccucgaga agucccgcgu cguccaccag aaccacggcg agcgcaacuu ccacaucuuc      720

uaccagcucc ucgagggcgg cgaggaggag acccuccgcc gccucggccu cgagcgcaac      780

ccccaguccu accucuaccu cgucaagggc cagugcgcca aggucuccuc caucaacgac      840

aaguccgacu ggaaggucgu ccgcaaggcc cucaccguca ucgacuucac cgaggacgag      900

gucgaggacc uccucuccau cgucgccucc guccuccacc ucggcaacau ccacuucgcc      960

gccaacgagg aguccaacgc ccaggucacc accgagaacc agcucaagua ccucacccgc     1020

cuccucuccg ucgagggcuc cacccuccgc gaggcccuca cccaccgcaa gaucaucgcc     1080

aagggcgagg agcuccucuc cccccucaac cucgagcagg ccgccuacgc ccgcgacgcc     1140

cucgccaagg ccgucuacuc ccgcaccuuc accuggcucg ucggcaagau caaccgcucc     1200

cucgccucca aggacgucga gucccccucc uggcgcucca ccaccguccu cggccuccuc     1260

gacaucuacg gcuucgaggu cuuccagcac aacuccuucg agcaguucug caucaacuac     1320

ugcaacgaga agcuccagca gcucuucauc gagcucaccc ucaaguccga gcaggaggag     1380

uacgaggccg agggcaucgc cugggagccc guccaguacu ucaacaacaa gaucaucugc     1440

gaccucgucg aggagaaguu caagggcauc aucuccaucc ucgacgagga gugccuccgc     1500

cccggcgagg ccaccgaccu caccuuccuc gagaagcucg aggacaccgu caagcaccac     1560

ccccacuucc ucacccacaa gcucgccgac cagcgcaccc gcaagucccu cggccgcggc     1620

gaguuccgcc uccuccacua cgccggcgag gucaccuacu ccgucaccgg cuuccucgac     1680

aagaacaacg accuccucuu ccgcaaccuc aaggagacca ugugcuccuc caagaacccc     1740

aucauguccc agugcuucga ccgcuccgag cucuccgaca agaagcgccc cgagaccguc     1800

gccacccagu ucaagauguc ccuccuccag cucgucgaga uccuccaguc caaggagccc     1860

gccuacgucc gcugcaucaa gcccaacgac gccaagcagc ccggccgcuu cgacgagguc     1920

cucauccgcc accaggucaa guaccucggc cuccucgaga accuccgcgu ccgccgcgcc     1980

ggcuucgccu accgccgcaa guacgaggcc uuccuccagc gcuacaaguc ccucugcccc     2040

gagaccuggc ccaccugggc cggccgcccc caggacggcg ucgccguccu cguccgccac     2100

cucggcuaca agcccgagga guacaagaug ggccgcacca agaucuucau ccgcuucccc     2160

aagacccucu ucgccaccga ggacgcccuc gagguccgcc gccagucccu cgccaccaag     2220

auccaggccg ccuggcgcgg cuuccacugg cgccagaagu uccuccgcgu caagcgcucc     2280

gccaucugca uccaguccug guggcgcggc acccucggcc gccgcaaggc cgccaagcgc     2340

aagugggccg cccagaccau ccgccgccuc auccgcggcu ucguccuccg ccacgccccc     2400

cgcugccccg agaacgccuu cuuccucgac cacguccgca ccuccuuccu ccucaaccuc     2460

cgccgccagc ucccccagaa cguccucgac accuccuggc ccaccccccc ccccgcccuc     2520

cgcgaggccu ccgagcuccu ccgcgagcuc ugcaucaaga acauggucug gaaguacugc     2580

cgcuccaucu cccccgagug gaagcagcag cuccagcaga aggccgucgc cuccgagauc     2640

uucaagggca agaaggacaa cuacccccag uccguccccc gccucuucau cuccacccgc     2700

cucggcaccg acgagaucuc cccccgcguc cuccaggccc ucggcuccga gcccauccag     2760

uacgccgucc ccgucgucaa guacgaccgc aagggcuaca agccccgcuc ccgccagcuc     2820

cuccucaccc ccaacgccgu cgucaucguc gaggacgcca aggucaagca gcgcaucgac     2880

uacgccaacc ucaccggcau cuccgucucc ucccucuccg acucccucuu cguccuccac     2940

guccagcgcg ccgacaacaa gcagaagggc gacgucgucc uccaguccga ccacgucauc     3000

gagacccuca ccaagaccgc ccucuccgcc aaccgcguca acuccaucaa caucaaccag     3060

ggcuccauca ccuucgccgg cggccccggc cgcgacggca ccaucgacuu cacccccggc     3120

uccgagcucc ucaucaccaa ggccaagaac ggccaccucg ccgucgucgc cccccgccuc     3180

aacucccgcu ga                                                         3192


<210>  2810
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1C__Homo_sapiens__CCDS42226.1

<400>  2810
auggcccuuc agguggagcu cguccccacc ggcgaaauca uuagaguugu gcacccucau       60

aggccaugca agcuggcucu ggggagcgac ggaguacggg ugacaaugga guccgcauug      120

acugcccgcg aucgagucgg ugugcaagac uucguuuuac uggaaaacuu uacgucugag      180

gcggcuuuca uagaaaaucu acguagaagg uuucgggaga accucaucua caccuauauu      240

ggcccggugc uggucucagu gaaucccuac cgcgaucuuc agaucuauag uagacagcac      300

auggagaggu accgcggggu uagcuucuau gaaguaccuc cacaucuguu ugccguggca      360

gacacagucu accgggccuu gcgaacugag agaagggauc aggcugugau gauuuccgga      420

gaaucuggcg cagguaaaac cgaggccaca aagcggcucc ugcaauucua ugcugagacc      480

ugucccgccc cugaacgugg gggagcggug cgcgacagac ugcuccaguc gaacccaguc      540

uuagaggcau uuggcaaugc caaaacucug aggaacgaua auucaagccg guucggcaag      600

uacauggacg uucaguuuga uuucaaaggg gcucccgugg gaggucacau ccuuaguuac      660

uugcuggaaa agucccgagu agugcaucag aaccacggcg agcgcaauuu ucacauauuc      720

uaucaacuac ucgaaggggg agaggaggaa acacugagaa ggcuuggccu ggagcggaac      780

ccucagucuu acuuguaucu cgucaagggu cagugcgcca aagugagcuc caucaaugac      840

aagucagauu ggaaaguugu gcgcaaggca cugaccguca uugacuuuac ggaagaugag      900

guggaagacu uacugaguau cguagcuagc guucuccauc uugggaacau ucacuucgcc      960

gcgaaugagg agucuaacgc ccaggugacu accgaaaauc aacugaaaua cuugacaaga     1020

cuacuguccg ucgagggauc aacucucagg gaagcacuga cccaucguaa gaucauagcu     1080

aagggcgagg aacuucugag cccauugaac cucgagcagg ccgcuuaugc ccgggacgca     1140

cuggccaaag cuguguacag ucgaacauuc accugguuag ucggcaagau uaacagaucu     1200

cuggcgucca aagaugugga gagcccgucg uggaggucua cgacuguucu agggcuccug     1260

gacaucuaug gauuugaagu guuccagcac aauuccuuug agcaauucug uauuaacuac     1320

ugcaaugaaa aacuucagca guuguuuauc gagcugacac ucaagucaga gcaggaagag     1380

uacgaagcag aggguaucgc cugggaaccc guacaauauu ucaacaauaa gauuauaugu     1440

gaucuggucg aggagaaauu uaagggcauc auuaguaucc uugacgaaga gugccugcgc     1500

ccuggggaag cuaccgauuu gacuuuccuc gagaagcugg aagacacagu gaaacaccau     1560

ccacacuuuu uaacccauaa gcuggccgau cagcggacga gaaaaagccu aggaaggggc     1620

gaguuccgcc uccugcacua cgcuggugag guuaccuauu ccgugacagg guuucuugac     1680

aagaacaaug auuugcuguu ccgaaaccuc aaagaaacua uguguucuag caagaauccc     1740

auaaugucac agugcuuuga ccggagugag cuguccgaua agaaacgucc ugaaaccguc     1800

gccacacagu ucaagaugag cuuacugcaa cuuguggaga uuuugcaguc uaaagaacca     1860

gcuuacguaa gauguaucaa gcccaacgac gccaaacagc cgggcagguu cgacgaggug     1920

cucauccgcc aucagguuaa guaucuggga cuacuggaga aucuccgggu cagaagggca     1980

ggcuuugcgu accgacgcaa guaugaggcu uuccugcaac gguacaaauc acuuugcccu     2040

gaaacuuggc ccaccugggc cgggagacca caggauggag uggcaguguu ggucaggcac     2100

cuggguuaca agccugaaga guauaaaaug ggccguacaa agauuuuuau ccgcuucccc     2160

aaaaccuuau uugccacuga ggacgcucuc gaaguucgga gacagagucu ggccacgaag     2220

auucaggcag cuuggagggg guuccacugg cgacaaaagu uucuucgggu gaaacgcagc     2280

gccauaugua uccaguccug guggagagga acacugggca ggcggaaggc ggccaaacga     2340

aagugggcug cacagaccau uagacgcuug aucagggguu ucgugcuccg ucaugcccca     2400

cggugccccg agaacgcauu uuuccuggau cacguaagaa cuucuuuucu acugaaucuc     2460

aggcgccaac ugccucagaa cguccuugac accucguggc caacaccgcc cccugccuug     2520

cgagaagcaa gcgagcuguu aagagaacuc ugcaucaaaa auauggugug gaaguacugu     2580

cgguccauuu caccagagug gaaacagcag cugcaacaga aggcgguugc cagugagaua     2640

uucaagggga aaaaggauaa cuauccccag ucugugccua ggcuuuuuau cagcacccgc     2700

cugggcacug acgaaauuuc cccacguguc cuacaggcuc ucggaucaga gcccauccaa     2760

uacgccgugc cgguugugaa auaugauaga aagggcuaca aaccucggag caggcagcug     2820

uugcugacac caaacgcagu agucauugug gaagacgcua aggugaagca gcgcaucgau     2880

uaugccaauu uaacggggau aucugucucc agucucagcg acucucuguu cguucuucau     2940

gugcagcgag cagauaacaa acaaaaggga gacguagugc ugcaguccga ucacgucauc     3000

gagaccuuga cuaaaacagc ccucucagcu aauagaguga acaguauuaa uaucaaccag     3060

gguagcauua ccuucgcggg cgggcccgga cgggacggca caaucgacuu uacuccuggu     3120

ucggaacugc uaauaaccaa ggccaaaaau gggcaccugg caguuguggc ucccaggcuu     3180

aacucccgcu ga                                                         3192


<210>  2811
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1C__Homo_sapiens__CCDS42226.1

<400>  2811
auggcccugc agguggagcu ggugcccacc ggcgagauca ucagaguggu gcacccccac       60

agacccugca agcuggcccu gggcagcgac ggcgugagag ugaccaugga gagcgcccug      120

accgccagag acagaguggg cgugcaggac uucgugcugc uggagaacuu caccagcgag      180

gccgccuuca ucgagaaccu gagaagaaga uucagagaga accugaucua caccuacauc      240

ggccccgugc uggugagcgu gaaccccuac agagaccugc agaucuacag cagacagcac      300

auggagagau acagaggcgu gagcuucuac gaggugcccc cccaccuguu cgccguggcc      360

gacaccgugu acagagcccu gagaaccgag agaagagacc aggccgugau gaucagcggc      420

gagagcggcg ccggcaagac cgaggccacc aagagacugc ugcaguucua cgccgagacc      480

ugccccgccc ccgagagagg cggcgccgug agagacagac ugcugcagag caaccccgug      540

cuggaggccu ucggcaacgc caagacccug agaaacgaca acagcagcag auucggcaag      600

uacauggacg ugcaguucga cuucaagggc gcccccgugg gcggccacau ccugagcuac      660

cugcuggaga agagcagagu ggugcaccag aaccacggcg agagaaacuu ccacaucuuc      720

uaccagcugc uggagggcgg cgaggaggag acccugagaa gacugggccu ggagagaaac      780

ccccagagcu accuguaccu ggugaagggc cagugcgcca aggugagcag caucaacgac      840

aagagcgacu ggaagguggu gagaaaggcc cugaccguga ucgacuucac cgaggacgag      900

guggaggacc ugcugagcau cguggccagc gugcugcacc ugggcaacau ccacuucgcc      960

gccaacgagg agagcaacgc ccaggugacc accgagaacc agcugaagua ccugaccaga     1020

cugcugagcg uggagggcag cacccugaga gaggcccuga cccacagaaa gaucaucgcc     1080

aagggcgagg agcugcugag cccccugaac cuggagcagg ccgccuacgc cagagacgcc     1140

cuggccaagg ccguguacag cagaaccuuc accuggcugg ugggcaagau caacagaagc     1200

cuggccagca aggacgugga gagccccagc uggagaagca ccaccgugcu gggccugcug     1260

gacaucuacg gcuucgaggu guuccagcac aacagcuucg agcaguucug caucaacuac     1320

ugcaacgaga agcugcagca gcuguucauc gagcugaccc ugaagagcga gcaggaggag     1380

uacgaggccg agggcaucgc cugggagccc gugcaguacu ucaacaacaa gaucaucugc     1440

gaccuggugg aggagaaguu caagggcauc aucagcaucc uggacgagga gugccugaga     1500

cccggcgagg ccaccgaccu gaccuuccug gagaagcugg aggacaccgu gaagcaccac     1560

ccccacuucc ugacccacaa gcuggccgac cagagaacca gaaagagccu gggcagaggc     1620

gaguucagac ugcugcacua cgccggcgag gugaccuaca gcgugaccgg cuuccuggac     1680

aagaacaacg accugcuguu cagaaaccug aaggagacca ugugcagcag caagaacccc     1740

aucaugagcc agugcuucga cagaagcgag cugagcgaca agaagagacc cgagaccgug     1800

gccacccagu ucaagaugag ccugcugcag cugguggaga uccugcagag caaggagccc     1860

gccuacguga gaugcaucaa gcccaacgac gccaagcagc ccggcagauu cgacgaggug     1920

cugaucagac accaggugaa guaccugggc cugcuggaga accugagagu gagaagagcc     1980

ggcuucgccu acagaagaaa guacgaggcc uuccugcaga gauacaagag ccugugcccc     2040

gagaccuggc ccaccugggc cggcagaccc caggacggcg uggccgugcu ggugagacac     2100

cugggcuaca agcccgagga guacaagaug ggcagaacca agaucuucau cagauucccc     2160

aagacccugu ucgccaccga ggacgcccug gaggugagaa gacagagccu ggccaccaag     2220

auccaggccg ccuggagagg cuuccacugg agacagaagu uccugagagu gaagagaagc     2280

gccaucugca uccagagcug guggagaggc acccugggca gaagaaaggc cgccaagaga     2340

aagugggccg cccagaccau cagaagacug aucagaggcu ucgugcugag acacgccccc     2400

agaugccccg agaacgccuu cuuccuggac cacgugagaa ccagcuuccu gcugaaccug     2460

agaagacagc ugccccagaa cgugcuggac accagcuggc ccaccccccc ccccgcccug     2520

agagaggcca gcgagcugcu gagagagcug ugcaucaaga acauggugug gaaguacugc     2580

agaagcauca gccccgagug gaagcagcag cugcagcaga aggccguggc cagcgagauc     2640

uucaagggca agaaggacaa cuacccccag agcgugccca gacuguucau cagcaccaga     2700

cugggcaccg acgagaucag ccccagagug cugcaggccc ugggcagcga gcccauccag     2760

uacgccgugc ccguggugaa guacgacaga aagggcuaca agcccagaag cagacagcug     2820

cugcugaccc ccaacgccgu ggugaucgug gaggacgcca aggugaagca gagaaucgac     2880

uacgccaacc ugaccggcau cagcgugagc agccugagcg acagccuguu cgugcugcac     2940

gugcagagag ccgacaacaa gcagaagggc gacguggugc ugcagagcga ccacgugauc     3000

gagacccuga ccaagaccgc ccugagcgcc aacagaguga acagcaucaa caucaaccag     3060

ggcagcauca ccuucgccgg cggccccggc agagacggca ccaucgacuu cacccccggc     3120

agcgagcugc ugaucaccaa ggccaagaac ggccaccugg ccgugguggc ccccagacug     3180

aacagcagau ga                                                         3192


<210>  2812
<211>  3192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1C__Homo_sapiens__CCDS42226.1

<400>  2812
auggcccucc agguggagcu cguccccacc ggcgaaauca uuagaguugu gcacccucau       60

cggccgugca agcuggcucu ugggagcgac ggagugcgcg ucacaaugga guccgcccug      120

acggcgagag aucggguggg cguucaagac uucgugcucc uggaaaacuu uaccucugag      180

gcugccuuca ucgaaaaucu ucgcagacgg uuucgcgaga accugauuua cacauauauc      240

gggcccgucc ucgugagcgu uaauccuuac agagaucugc agauuuauuc ccggcagcac      300

auggagcgcu acagaggagu gucuuucuau gaagugcccc cucaucuguu ugccgucgcu      360

gacaccgugu accgggcccu ccgcacagag agacgggauc aggcugucau gaucagcggc      420

gaauccgggg ccggaaaaac cgaggcgaca aagcgccugc uucaauucua ugccgagacc      480

ugucccgcuc cugaaagagg cggcgccguu cgggacagac ugcuccaguc uaacccggug      540

cuggaggcuu uugggaaugc caaaacgcuu cgcaacgaua auagcucccg guucggaaag      600

uacauggacg ugcaguuuga uuucaaaggc gcgcccgucg ggggacacau ccugagcuac      660

cuccuggaaa agucuagagu gguucaucag aaccacggcg agcgcaauuu ucacauuuuc      720

uaucaacugc ucgaaggggg agaggaggaa acccugcgga gacuuggccu ggagcgcaac      780

ccucaguccu accucuaucu ggugaagggc cagugcgcca aagucagcuc uaucaaugac      840

aaguccgauu ggaaaguggu ucggaaggcu cuuacaguga uugacuuuac cgaagaugag      900

gucgaagacc ugcucagcau cguggccucu guccugcauc uggggaacau ucacuucgcu      960

gccaaugagg aguccaacgc ccaggugaca accgaaaauc aacucaaaua ccugacgaga     1020

cuucugagcg uugagggauc cacacuccgc gaagcucuga cccaucggaa gaucauugcg     1080

aagggcgagg aacuucuguc uccccucaac cuggagcagg ccgcuuaugc cagagacgcc     1140

cuggcuaaag ccguguacag ccgcacauuc accuggcucg ucgggaagau caaccggucc     1200

cuggcgagca aagaugugga gucuccuucc uggagaagca ccacaguucu uggacugcuc     1260

gacaucuaug gcuuugaagu guuccagcac aauucuuuug agcaauucug uauuaacuac     1320

ugcaaugaaa agcugcagca gcuguuuauc gagcuuacgc ucaaaagcga gcaggaagag     1380

uacgaagcug aggggauugc cugggaaccc guccaauauu ucaacaauaa gaucauuugu     1440

gaucuggugg aggagaaauu uaagggaauc aucuccauuc uggacgaaga gugccuccgg     1500

ccgggcgaag ccaccgaucu gacauuccuu gagaagcugg aagacaccgu gaaacaccau     1560

ccucacuuuc ucacacauaa gcuggcugau cagcgcacca gaaaaucucu gggccgggga     1620

gaguucagac uucuccacua cgccggagag guuacguaua gcgucacagg cuuucuggac     1680

aagaacaaug aucugcuguu ccgcaaccug aaagaaacca uguguuccag caagaauccc     1740

aucaugucuc agugcuuuga ccgguccgag cuuagcgaua agaaaagacc ugaaaccgug     1800

gcuacacagu ucaagauguc ucugcuccaa cugguggaga uucugcaguc caaagaaccc     1860

gccuacgucc gcuguaucaa gcccaacgac gcgaaacagc cugggagauu cgacgaggug     1920

cuuauucggc aucagguuaa guaucucgga cugcuggaga aucuccgcgu gagacgggcc     1980

ggcuuugcuu accgcagaaa guaugaagcc uuccugcaac gguacaaaag ccuuugcccg     2040

gagaccuggc ccacaugggc ugggcgcccu caggauggcg ucgccgugcu gguuagacac     2100

cucggauaca agcccgaaga guauaaaaug ggccggacga agaucuuuau ccgcuucccu     2160

aaaacccugu uugcgacaga ggacgcccug gaagugagac ggcagucccu ugcuaccaag     2220

auucaggccg cuuggagagg guuccacugg cgccaaaagu uucuccgggu caaaagaucu     2280

gccaucugua uucagagcug guggcgcgga acacugggcc ggagaaaggc cgcuaaacgc     2340

aagugggcgg cccagaccau ccggagacug auucgcgggu ucgugcuccg gcaugcuccc     2400

agaugcccgg agaacgccuu uuuccuggau cacguucgga cguccuuucu ucugaaucuc     2460

cgcagacaac ugccucagaa cgugcuggac accucuuggc ccacaccucc cccugcccuu     2520

cgggaagcua gcgagcugcu ccgcgaacug ugcaucaaaa auauggucug gaaguacugu     2580

agauccauua gccccgagug gaaacagcag cuccaacaga aggccguggc gucugagauc     2640

uucaagggga aaaaggauaa cuauccgcag uccgugccuc ggcuguuuau cagcaccaga     2700

cuuggcacag acgaaauuuc uccccgcguc cugcaggcuc ucggguccga gcccauccaa     2760

uacgccguuc cuguggugaa auaugaucgg aagggcuaca aaccgagaag ccgccagcug     2820

cugcuuaccc ccaacgccgu cgugauuguu gaagacgcua aggugaagca gcggaucgau     2880

uaugccaauc ugacgggaau uucugucagc ucccucagcg acucucuguu cgugcuccau     2940

guucagagag cggauaacaa acaaaagggc gacguggucc ugcaguccga ucacgugauc     3000

gagacacuua ccaaaacagc ucugagcgcc aaucgcguua acuccaucaa uauuaaccag     3060

gggucuauca ccuucgccgg aggcccuggg cgggacggaa ccauugacuu uacacccggc     3120

agcgaacucc ugaucacgaa ggcuaaaaau gggcaccugg ccguggucgc uccuagacuu     3180

aacucccgcu ga                                                         3192


<210>  2813
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1D__Homo_sapiens__O94832

<400>  2813

Met Ala Glu Gln Glu Ser Leu Glu Phe Gly Lys Ala Asp Phe Val Leu 
1               5                   10                  15      


Met Asp Thr Val Ser Met Pro Glu Phe Met Ala Asn Leu Arg Leu Arg 
            20                  25                  30          


Phe Glu Lys Gly Arg Ile Tyr Thr Phe Ile Gly Glu Val Val Val Ser 
        35                  40                  45              


Val Asn Pro Tyr Lys Leu Leu Asn Ile Tyr Gly Arg Asp Thr Ile Glu 
    50                  55                  60                  


Gln Tyr Lys Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Phe Ala 
65                  70                  75                  80  


Ile Ala Asp Ala Ala Tyr Lys Ala Met Lys Arg Arg Ser Lys Asp Thr 
                85                  90                  95      


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110         


Lys Tyr Ile Met Gln Tyr Ile Ala Ala Ile Thr Asn Pro Ser Gln Arg 
        115                 120                 125             


Ala Glu Val Glu Arg Val Lys Asn Met Leu Leu Lys Ser Asn Cys Val 
    130                 135                 140                 


Leu Glu Ala Phe Gly Asn Ala Lys Thr Asn Arg Asn Asp Asn Ser Ser 
145                 150                 155                 160 


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175     


Ile Gly Gly His Ile Asn Asn Tyr Leu Leu Glu Lys Ser Arg Val Ile 
            180                 185                 190         


Val Gln Gln Pro Gly Glu Arg Ser Phe His Ser Phe Tyr Gln Leu Leu 
        195                 200                 205             


Gln Gly Gly Ser Glu Gln Met Leu Arg Ser Leu His Leu Gln Lys Ser 
    210                 215                 220                 


Leu Ser Ser Tyr Asn Tyr Ile His Val Gly Ala Gln Leu Lys Ser Ser 
225                 230                 235                 240 


Ile Asn Asp Ala Ala Glu Phe Arg Val Val Ala Asp Ala Met Lys Val 
                245                 250                 255     


Ile Gly Phe Lys Pro Glu Glu Ile Gln Thr Val Tyr Lys Ile Leu Ala 
            260                 265                 270         


Ala Ile Leu His Leu Gly Asn Leu Lys Phe Val Val Asp Gly Asp Thr 
        275                 280                 285             


Pro Leu Ile Glu Asn Gly Lys Val Val Ser Ile Ile Ala Glu Leu Leu 
    290                 295                 300                 


Ser Thr Lys Thr Asp Met Val Glu Lys Ala Leu Leu Tyr Arg Thr Val 
305                 310                 315                 320 


Ala Thr Gly Arg Asp Ile Ile Asp Lys Gln His Thr Glu Gln Glu Ala 
                325                 330                 335     


Ser Tyr Gly Arg Asp Ala Phe Ala Lys Ala Ile Tyr Glu Arg Leu Phe 
            340                 345                 350         


Cys Trp Ile Val Thr Arg Ile Asn Asp Ile Ile Glu Val Lys Asn Tyr 
        355                 360                 365             


Asp Thr Thr Ile His Gly Lys Asn Thr Val Ile Gly Val Leu Asp Ile 
    370                 375                 380                 


Tyr Gly Phe Glu Ile Phe Asp Asn Asn Ser Phe Glu Gln Phe Cys Ile 
385                 390                 395                 400 


Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Val Leu 
                405                 410                 415     


Lys Gln Glu Gln Glu Glu Tyr Gln Arg Glu Gly Ile Pro Trp Lys His 
            420                 425                 430         


Ile Asp Tyr Phe Asn Asn Gln Ile Ile Val Asp Leu Val Glu Gln Gln 
        435                 440                 445             


His Lys Gly Ile Ile Ala Ile Leu Asp Asp Ala Cys Met Asn Val Gly 
    450                 455                 460                 


Lys Val Thr Asp Glu Met Phe Leu Glu Ala Leu Asn Ser Lys Leu Gly 
465                 470                 475                 480 


Lys His Ala His Phe Ser Ser Arg Lys Leu Cys Ala Ser Asp Lys Ile 
                485                 490                 495     


Leu Glu Phe Asp Arg Asp Phe Arg Ile Arg His Tyr Ala Gly Asp Val 
            500                 505                 510         


Val Tyr Ser Val Ile Gly Phe Ile Asp Lys Asn Lys Asp Thr Leu Phe 
        515                 520                 525             


Gln Asp Phe Lys Arg Leu Met Tyr Asn Ser Ser Asn Pro Val Leu Lys 
    530                 535                 540                 


Asn Met Trp Pro Glu Gly Lys Leu Ser Ile Thr Glu Val Thr Lys Arg 
545                 550                 555                 560 


Pro Leu Thr Ala Ala Thr Leu Phe Lys Asn Ser Met Ile Ala Leu Val 
                565                 570                 575     


Asp Asn Leu Ala Ser Lys Glu Pro Tyr Tyr Val Arg Cys Ile Lys Pro 
            580                 585                 590         


Asn Asp Lys Lys Ser Pro Gln Ile Phe Asp Asp Glu Arg Cys Arg His 
        595                 600                 605             


Gln Val Glu Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala 
    610                 615                 620                 


Gly Phe Ala Phe Arg Gln Thr Tyr Glu Lys Phe Leu His Arg Tyr Lys 
625                 630                 635                 640 


Met Ile Ser Glu Phe Thr Trp Pro Asn His Asp Leu Pro Ser Asp Lys 
                645                 650                 655     


Glu Ala Val Lys Lys Leu Ile Glu Arg Cys Gly Phe Gln Asp Asp Val 
            660                 665                 670         


Ala Tyr Gly Lys Thr Lys Ile Phe Ile Arg Thr Pro Arg Thr Leu Phe 
        675                 680                 685             


Thr Leu Glu Glu Leu Arg Ala Gln Met Leu Ile Arg Ile Val Leu Phe 
    690                 695                 700                 


Leu Gln Lys Val Trp Arg Gly Thr Leu Ala Arg Met Arg Tyr Lys Arg 
705                 710                 715                 720 


Thr Lys Ala Ala Leu Thr Ile Ile Arg Tyr Tyr Arg Arg Tyr Lys Val 
                725                 730                 735     


Lys Ser Tyr Ile His Glu Val Ala Arg Arg Phe His Gly Val Lys Thr 
            740                 745                 750         


Met Arg Asp Tyr Gly Lys His Val Lys Trp Pro Ser Pro Pro Lys Val 
        755                 760                 765             


Leu Arg Arg Phe Glu Glu Ala Leu Gln Thr Ile Phe Asn Arg Trp Arg 
    770                 775                 780                 


Ala Ser Gln Leu Ile Lys Ser Ile Pro Ala Ser Asp Leu Pro Gln Val 
785                 790                 795                 800 


Arg Ala Lys Val Ala Ala Val Glu Met Leu Lys Gly Gln Arg Ala Asp 
                805                 810                 815     


Leu Gly Leu Gln Arg Ala Trp Glu Gly Asn Tyr Leu Ala Ser Lys Pro 
            820                 825                 830         


Asp Thr Pro Gln Thr Ser Gly Thr Phe Val Pro Val Ala Asn Glu Leu 
        835                 840                 845             


Lys Arg Lys Asp Lys Tyr Met Asn Val Leu Phe Ser Cys His Val Arg 
    850                 855                 860                 


Lys Val Asn Arg Phe Ser Lys Val Glu Asp Arg Ala Ile Phe Val Thr 
865                 870                 875                 880 


Asp Arg His Leu Tyr Lys Met Asp Pro Thr Lys Gln Tyr Lys Val Met 
                885                 890                 895     


Lys Thr Ile Pro Leu Tyr Asn Leu Thr Gly Leu Ser Val Ser Asn Gly 
            900                 905                 910         


Lys Asp Gln Leu Val Val Phe His Thr Lys Asp Asn Lys Asp Leu Ile 
        915                 920                 925             


Val Cys Leu Phe Ser Lys Gln Pro Thr His Glu Ser Arg Ile Gly Glu 
    930                 935                 940                 


Leu Val Gly Val Leu Val Asn His Phe Lys Ser Glu Lys Arg His Leu 
945                 950                 955                 960 


Gln Val Asn Val Thr Asn Pro Val Gln Cys Ser Leu His Gly Lys Lys 
                965                 970                 975     


Cys Thr Val Ser Val Glu Thr Arg Leu Asn Gln Pro Gln Pro Asp Phe 
            980                 985                 990         


Thr Lys Asn Arg Ser Gly Phe Ile Leu Ser Val Pro Gly Asn 
        995                 1000                1005    


<210>  2814
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1D__Homo_sapiens__AAI46764

<400>  2814
auggcggagc aggagagccu ggaauucggc aaggcagacu ucgugcugau ggacaccguc       60

uccaugcccg aguucauggc caaccucagg cucagauuug aaaaagggcg caucuauacg      120

uucauuggag aagucgucgu uucugugaac ccuuacaagu uguugaacau cuauggaaga      180

gacacaauug agcaguauaa aggccgugag cuguaugaga gaccgccuca ccuuuuugcu      240

auugcggaug cugcuuacaa ggcuaugaag aggcgaucaa aagacacuug uauugugaua      300

ucaggggaaa guggagcugg uaaaacggaa gccaguaagu acauuaugca guauauugcg      360

gccaucacca accccaguca gagagcagag guugaaagag ugaagaauau guugcuuaag      420

uccaacugug uuuuggaagc uuuuggaaau gccaaaacca accguaauga caacucaagc      480

agguuuggaa aauacaugga uaucaacuuu gacuucaagg gugacccuau uggugggcau      540

aucaauaacu acuuacuaga aaagucucga gugauugugc aacagccagg agaaagaagc      600

uuucauucuu ucuaucagcu acuccaagga gguucagaac aaaugcuacg cucucuacau      660

cuccagaaau cccuuucauc cuacaacuau auucaugugg gagcucaauu aaagucuucu      720

aucaaugaug cugccgaauu cagaguuguu gcugaugcca ugaaagucau uggcuucaaa      780

ccugaggaga uccaaacagu guauaagauu uuggcugcua uucugcacuu gggaaauuua      840

aaauuuguag uagaugguga cacgccucuu auugagaaug gcaaaguagu aucuaucaua      900

gcagaauugc ucucuacuaa gacagauaug guugagaaag cccuucuuua ccggacugug      960

gccacaggcc gugacaucau ugacaagcag cacacagaac aagaggccag cuacggcaga     1020

gacgccuuug ccaaggcaau auaugagcgc cuuuuuuguu ggaucguuac ucgcaucaau     1080

gauauuauug aggucaagaa cuaugacacc acaauccaug ggaaaaacac uguuauuggu     1140

gucuuggaua ucuauggcuu ugaaaucuuc gacaacaaca guuuugaaca auucuguauc     1200

aauuacugca augagaaacu gcagcagcua uuuauucagc ugguucugaa gcaagaacaa     1260

gaggaauacc agcgggaagg gauccccugg aaacauauug acuacuucaa caaucagauc     1320

auuguugacc ucguggagca acagcacaaa gggaucauug caauccuuga ugaugcuugc     1380

augaaugucg gcaaagucac cgaugaaaug uuucuugaag cacuuaacag uaaauugggc     1440

aaacacgccc auuuuuccag ccgaaagcuc ugugccucag acaaaauucu ggaguuugau     1500

cgagauuuuc gaauucgaca uuaugcaggc gauguagucu auucugucau ugguuuuauu     1560

gacaaaaaua aagauacuuu auuucaagau uucaagcgcc uuauguauaa caguucaaau     1620

ccugugcuca agaauaugug gccugaaggc aaacugagca uuacagaggu gaccaagcga     1680

ccucugacug cugcuaccuu guuuaagaau ucuaugauug cucuaguaga caaccuugca     1740

ucaaaggaac cauauuacgu ucguugcauc aaacccaaug acaagaaauc uccacagaua     1800

uuugaugaug aacgcugccg gcaccaagua gaauaucuug gacuacugga aaaugugaga     1860

gugcgucggg caggauuugc cuuccgccag acauacgaga aguuucuuca cagguauaag     1920

augaucucug aauucaccug gcccaaccau gaccuuccuu cagacaaaga ggcugucaag     1980

aaacuaauug aacggugugg uuuucaggau gauguagcuu augggaagac caaaauuuuc     2040

auucgaacac cccgaacauu guuuaccuug gaagaacucc gugcccagau gcucauaagg     2100

auuguccucu uucuacaaaa gguguggcgg ggcacccugg cccgcaugcg guacaaaaga     2160

accaaggcag cucugacaau aaucagguac uaccggcgcu acaaagugaa gucguacauc     2220

cacgaggugg ccagacgcuu ccauggcguc aagaccaugc gagacuacgg gaagcacgug     2280

aaguggccaa gcccuccuaa aguucuucgc cguuuugagg aggcccugca gacgauuuuc     2340

aauagaugga gagcauccca gcucaucaag agcauuccgg ccucagaccu gccccagguc     2400

agggcaaagg uugcagccgu ggaaauguug aagggucaaa gggcugaccu cgggcuccag     2460

agggccuggg agggcaacua ucuugcuuca aagccagaua caccucagac cucaggcacu     2520

uuugucccug uugcuaauga auugaaacgg aaggacaaau acaugaaugu ccucuuuucc     2580

ugucacgucc guaagguaaa ucgauuuagu aagguggaag acagagcaau uuuugucacu     2640

gaccgucacc uguauaaaau ggaucccacu aaacaguaca aggugaugaa gacuaucccu     2700

cuauacaauu ugacuggucu gagugucucc aauggaaagg accaacuugu aguguuccau     2760

acgaaagaca acaaagaccu cauugucugc cucuucagca aacagccaac ccaugagagu     2820

cgaauuggag aacuuguugg agugcuggug aaucauuuca agagugagaa gcgccaccuu     2880

caagugaacg ucaccaaccc aguacagugc agccugcacg ggaagaagug caccgucucc     2940

guggagacgc ggcucaacca gccccagccc gacuucacca agaaucgcuc gggcuucauc     3000

cucagcgugc ccgggaacug a                                               3021


<210>  2815
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1D__Homo_sapiens__AAI46764

<400>  2815
auggccgagc aggagagccu ggaguucggc aaggccgacu ucgugcucau ggacaccguc       60

uccaugcccg aguucauggc gaaccugcgc cugcgguucg agaaggggcg caucuacacc      120

uucaucggcg aggugguggu cagcgugaac ccguacaagc uccugaacau cuacgggcgg      180

gacacgaucg agcaguacaa gggccgcgag cuguacgagc ggccgcccca ccucuucgcc      240

aucgccgacg ccgccuacaa ggcgaugaag cgccggucca aggacacgug caucgugauc      300

agcggggagu ccggcgccgg caagaccgag gccagcaagu acaucaugca guacaucgcc      360

gcgaucacca accccuccca gcgcgccgag gucgagcggg ugaagaacau gcugcucaag      420

agcaacugcg ugcuggaggc cuucgggaac gccaagacca accgcaacga caacuccagc      480

cgguucggca aguacaugga caucaacuuc gacuucaagg gggaccccau cggcgggcac      540

aucaacaacu accugcugga gaagucccgc gucaucgugc agcagcccgg cgagcggagc      600

uuccacuccu ucuaccagcu ccugcagggc gggagcgagc agaugcugcg cucccuccac      660

cuccagaagu cccugagcag cuacaacuac auccacgugg gcgcccagcu gaaguccagc      720

aucaacgacg cggccgaguu ccgggucgug gccgacgcca ugaaggugau cggguucaag      780

cccgaggaga uccagaccgu cuacaagauc cuggccgcga uccugcaccu cggcaaccug      840

aaguucgugg uggacggcga cacgccccug aucgagaacg ggaaggucgu gagcaucauc      900

gccgagcucc uguccaccaa gaccgacaug guggagaagg cccugcucua ccgcaccguc      960

gccaccggcc gggacaucau cgacaagcag cacaccgagc aggaggccag cuacgggcgc     1020

gacgcguucg ccaaggccau cuacgagcgg cuguucugcu ggaucgugac gcgcaucaac     1080

gacaucaucg aggugaagaa cuacgacacc accauccacg gcaagaacac cgucaucggg     1140

gugcuggaca ucuacggcuu cgagaucuuc gacaacaacu ccuucgagca guucugcauc     1200

aacuacugca acgagaagcu ccagcagcug uucauccagc ugguccucaa gcaggagcag     1260

gaggaguacc agcgggaggg caucccgugg aagcacaucg acuacuucaa caaccagauc     1320

aucguggacc ugguggagca gcagcacaag gggaucaucg ccauccugga cgacgccugc     1380

augaacgucg gcaaggugac ggacgagaug uuccucgagg cgcugaacag caagcugggg     1440

aagcacgccc acuucuccag ccgcaagcuc ugcgccuccg acaagauccu ggaguucgac     1500

cgcgacuucc ggauccgcca cuacgccggc gacguggucu acagcgugau cggguucauc     1560

gacaagaaca aggacacccu guuccaggac uucaagcggc ucauguacaa cuccagcaac     1620

cccgugcuga agaacaugug gcccgagggc aagcugucca ucaccgaggu caccaagcgc     1680

ccccucacgg cggccacccu guucaagaac agcaugaucg cccuggugga caaccucgcc     1740

uccaaggagc cguacuacgu gcggugcauc aagcccaacg acaagaaguc cccgcagauc     1800

uucgacgacg agcgcugccg gcaccagguc gaguaccugg gccugcugga gaacgugcgc     1860

gugcggcgcg ccggguucgc guuccggcag accuacgaga aguuccucca ccgcuacaag     1920

augaucagcg aguucaccug gcccaaccac gaccugccca gcgacaagga ggccgucaag     1980

aagcugaucg agcggugcgg cuuccaggac gacguggccu acgggaagac gaagaucuuc     2040

auccgcacgc cccggacccu cuucacccug gaggagcugc gcgcccagau gcucauccgg     2100

aucgugcugu uccugcagaa ggucuggcgc ggcacccucg cccggaugcg cuacaagcgc     2160

accaaggcgg cccugaccau cauccgguac uaccgccggu acaaggugaa guccuacauc     2220

cacgaggugg cccgccgguu ccacgggguc aagaccaugc gcgacuacgg caagcacgug     2280

aaguggccca gcccgcccaa ggugcugcgg cgcuucgagg aggcccucca gacgaucuuc     2340

aaccgguggc gcgccuccca gcugaucaag agcauccccg cgagcgaccu gccccagguc     2400

cgggccaagg uggccgccgu ggagaugcuc aagggccagc gcgcggaccu ggggcugcag     2460

cgggccuggg agggcaacua ccucgccucc aagcccgaca ccccgcagac cagcgggacc     2520

uucguccccg uggccaacga gcugaagcgc aaggacaagu acaugaacgu gcuguucucc     2580

ugccacgucc ggaaggugaa ccgcuucagc aagguggagg accgggccau cuucgucacg     2640

gaccgccacc ucuacaagau ggaccccacc aagcaguaca aggugaugaa gaccaucccc     2700

cuguacaacc ugaccggccu cuccgugagc aacggcaagg accagcuggu cguguuccac     2760

accaaggaca acaaggaccu gaucgugugc cucuucucca agcagccgac gcacgagagc     2820

cggaucgggg agcuggucgg cgugcuggug aaccacuuca aguccgagaa gcgccaccuc     2880

caggucaacg ugaccaaccc cgugcagugc agccugcacg ggaagaagug caccgucucc     2940

guggagaccc ggcugaacca gccccagccg gacuucacga agaaccgcag cggcuucauc     3000

cucuccgugc ccgggaacug a                                               3021


<210>  2816
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1D__Homo_sapiens__AAI46764

<400>  2816
auggccgagc aggagucccu cgaguucggc aaggccgacu ucguccucau ggacaccguc       60

uccaugcccg aguucauggc caaccuccgc cuccgcuucg agaagggccg caucuacacc      120

uucaucggcg aggucgucgu cuccgucaac cccuacaagc uccucaacau cuacggccgc      180

gacaccaucg agcaguacaa gggccgcgag cucuacgagc gcccccccca ccucuucgcc      240

aucgccgacg ccgccuacaa ggccaugaag cgccgcucca aggacaccug caucgucauc      300

uccggcgagu ccggcgccgg caagaccgag gccuccaagu acaucaugca guacaucgcc      360

gccaucacca accccuccca gcgcgccgag gucgagcgcg ucaagaacau gcuccucaag      420

uccaacugcg uccucgaggc cuucggcaac gccaagacca accgcaacga caacuccucc      480

cgcuucggca aguacaugga caucaacuuc gacuucaagg gcgaccccau cggcggccac      540

aucaacaacu accuccucga gaagucccgc gucaucgucc agcagcccgg cgagcgcucc      600

uuccacuccu ucuaccagcu ccuccagggc ggcuccgagc agaugcuccg cucccuccac      660

cuccagaagu cccucuccuc cuacaacuac auccacgucg gcgcccagcu caaguccucc      720

aucaacgacg ccgccgaguu ccgcgucguc gccgacgcca ugaaggucau cggcuucaag      780

cccgaggaga uccagaccgu cuacaagauc cucgccgcca uccuccaccu cggcaaccuc      840

aaguucgucg ucgacggcga caccccccuc aucgagaacg gcaaggucgu cuccaucauc      900

gccgagcucc ucuccaccaa gaccgacaug gucgagaagg cccuccucua ccgcaccguc      960

gccaccggcc gcgacaucau cgacaagcag cacaccgagc aggaggccuc cuacggccgc     1020

gacgccuucg ccaaggccau cuacgagcgc cucuucugcu ggaucgucac ccgcaucaac     1080

gacaucaucg aggucaagaa cuacgacacc accauccacg gcaagaacac cgucaucggc     1140

guccucgaca ucuacggcuu cgagaucuuc gacaacaacu ccuucgagca guucugcauc     1200

aacuacugca acgagaagcu ccagcagcuc uucauccagc ucguccucaa gcaggagcag     1260

gaggaguacc agcgcgaggg cauccccugg aagcacaucg acuacuucaa caaccagauc     1320

aucgucgacc ucgucgagca gcagcacaag ggcaucaucg ccauccucga cgacgccugc     1380

augaacgucg gcaaggucac cgacgagaug uuccucgagg cccucaacuc caagcucggc     1440

aagcacgccc acuucuccuc ccgcaagcuc ugcgccuccg acaagauccu cgaguucgac     1500

cgcgacuucc gcauccgcca cuacgccggc gacgucgucu acuccgucau cggcuucauc     1560

gacaagaaca aggacacccu cuuccaggac uucaagcgcc ucauguacaa cuccuccaac     1620

cccguccuca agaacaugug gcccgagggc aagcucucca ucaccgaggu caccaagcgc     1680

ccccucaccg ccgccacccu cuucaagaac uccaugaucg cccucgucga caaccucgcc     1740

uccaaggagc ccuacuacgu ccgcugcauc aagcccaacg acaagaaguc cccccagauc     1800

uucgacgacg agcgcugccg ccaccagguc gaguaccucg gccuccucga gaacguccgc     1860

guccgccgcg ccggcuucgc cuuccgccag accuacgaga aguuccucca ccgcuacaag     1920

augaucuccg aguucaccug gcccaaccac gaccuccccu ccgacaagga ggccgucaag     1980

aagcucaucg agcgcugcgg cuuccaggac gacgucgccu acggcaagac caagaucuuc     2040

auccgcaccc cccgcacccu cuucacccuc gaggagcucc gcgcccagau gcucauccgc     2100

aucguccucu uccuccagaa ggucuggcgc ggcacccucg cccgcaugcg cuacaagcgc     2160

accaaggccg cccucaccau cauccgcuac uaccgccgcu acaaggucaa guccuacauc     2220

cacgaggucg cccgccgcuu ccacggcguc aagaccaugc gcgacuacgg caagcacguc     2280

aaguggcccu ccccccccaa gguccuccgc cgcuucgagg aggcccucca gaccaucuuc     2340

aaccgcuggc gcgccuccca gcucaucaag uccauccccg ccuccgaccu cccccagguc     2400

cgcgccaagg ucgccgccgu cgagaugcuc aagggccagc gcgccgaccu cggccuccag     2460

cgcgccuggg agggcaacua ccucgccucc aagcccgaca ccccccagac cuccggcacc     2520

uucguccccg ucgccaacga gcucaagcgc aaggacaagu acaugaacgu ccucuucucc     2580

ugccacgucc gcaaggucaa ccgcuucucc aaggucgagg accgcgccau cuucgucacc     2640

gaccgccacc ucuacaagau ggaccccacc aagcaguaca aggucaugaa gaccaucccc     2700

cucuacaacc ucaccggccu cuccgucucc aacggcaagg accagcucgu cgucuuccac     2760

accaaggaca acaaggaccu caucgucugc cucuucucca agcagcccac ccacgagucc     2820

cgcaucggcg agcucgucgg cguccucguc aaccacuuca aguccgagaa gcgccaccuc     2880

caggucaacg ucaccaaccc cguccagugc ucccuccacg gcaagaagug caccgucucc     2940

gucgagaccc gccucaacca gccccagccc gacuucacca agaaccgcuc cggcuucauc     3000

cucuccgucc ccggcaacug a                                               3021


<210>  2817
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1D__Homo_sapiens__AAI46764

<400>  2817
auggccgagc aggaaagccu ggaguucggc aaggcugacu uugugcucau ggauaccguc       60

uccaugcccg aguucauggc aaaccuuaga cugagguuug agaaagggcg gaucuacaca      120

uucauuggag aaguuguggu aucugugaau ccuuauaagu uguuaaacau auacggucgc      180

gacacuaucg agcaauauaa aggccgagag cuguacgaac guccaccgca ccuauuugcc      240

auugcggaug cugccuauaa ggcaaugaaa agaaggucaa aggacacgug caucgucauu      300

aguggggaga gcggagccgg caagaccgag gcuuccaaau acaucaugca guauauagca      360

gccaucacaa aucccucuca gcgggcugaa guggagcgcg uuaagaacau gcuccugaaa      420

ucgaauugug ugcuugaagc cuucgguaac gcgaagacua auagaaacga uaauucaagc      480

agguuuggga aauacaugga cauuaacuuc gauuuuaagg gagacccuau cggcggccau      540

auuaauaacu accuguugga gaagagucgg gucaucgugc agcaaccagg ggaacgcucc      600

uuccacucuu uuuaucagcu ccugcaggga gguagcgagc agaugcugcg aucccuccau      660

uuacaaaaau cacugaguag cuacaauuau auacacguag gcgcacagcu uaagucuucc      720

auuaacgaug ccgcugaguu cagaguugug gccgacgcaa ugaaagucau cggguuuaag      780

cccgaagaga uucagaccgu guacaaaauc uuggcugcca uccugcaucu aggaaaucuc      840

aaguucgugg ucgauggcga cacaccucug auugaaaacg guaaaguugu gucaauaauc      900

gcggagcuuc ugagcaccaa gacugauaug guagaaaagg ccuugcucua uaggacagug      960

gcaaccgggc gggacauuau cgacaaacag cacacggagc aagaagcuag uuacggacgu     1020

gaugccuucg cuaaggccau auaugagcgc cuguuuugcu ggauugucac uagaaucaac     1080

gacaucauug aggugaaaaa uuacgauacc acaauccacg gcaagaacac uguuauuggc     1140

guguuagaca uauacggguu cgaaaucuuu gauaauaacu cuuucgagca guuuuguauu     1200

aauuauugca acgaaaaacu gcagcaacuc uucauccagc uuguccugaa gcaggagcag     1260

gaagaguacc aaagggaggg aaucccaugg aagcauauug acuauuuuaa uaaccagaua     1320

aucguggauu ugguagaaca gcagcacaaa gguauuaucg caauucuaga cgaugccugu     1380

augaauguug gcaaggugac cgacgagaug uuccuggaag cucucaacuc caaacugggg     1440

aagcaugcgc acuuuagcuc gcggaaacuu ugcgcaucug auaagauccu ggaguucgac     1500

cgagacuuuc gcauaagaca cuacgccgga gaugucgugu auuccgucau cggcuucauu     1560

gacaagaaua aagauacauu guuucaagac uucaagaggc ucauguacaa cucaaguaau     1620

cccgugcuga aaaacaugug gccugagggu aaguuaagca ucaccgaagu uacgaaacgg     1680

ccacugacug cugccacacu auucaaaaau uccaugauug cacucgugga uaaccuggcc     1740

ucuaaggagc cguauuacgu acgcuguauc aagcccaacg acaagaaaag cccucagaua     1800

uuugaugacg aaagaugcag gcaucagguc gaguaccuug gguugcugga aaaugugcgu     1860

guucggcgag cuggcuucgc cuuuagacag accuaugaga aguuccucca cagguacaaa     1920

augauuucag aguuuacuug gccaaaccau gaucugccca gugacaagga agcagugaaa     1980

aagcugaucg agcgcugugg auuccaagau gacgucgcgu auggcaagac aaaaauuuuu     2040

auccggaccc cuagaacgcu uuucaccuug gaagaacuca gggcucagau gcugauacgc     2100

aucguguuau uucugcagaa gguauggcga gggacacuag cccggaugcg uuacaaaaga     2160

acuaaggcag cccucaccau uaucagguau uaccgccggu auaaagugaa guccuacauu     2220

cacgaaguug cuagaagguu ccauggaguc aagacaaugc gagauuacgg uaaacacgug     2280

aaguggccau cacccccgaa agugcugcgc cgguuugagg aggcccuuca gacuaucuuc     2340

aauagaugga gggcaucuca auugauaaag ucaauuccug cuagugaccu gccccagguc     2400

cgugccaaag uugcggccgu ggaaaugcuc aagggccagc gcgcugaccu gggguuacaa     2460

cgggcauggg agggaaacua ucuggccagc aagccagaua ccccucagac auccggcacc     2520

uuugugcccg uagcuaauga acuuaaaaga aaggacaaau acaugaacgu cuuguucucu     2580

ugccacguga ggaagguuaa ucgauucucg aaaguggagg aucgggccau cuuugucacu     2640

gaccgccauc ucuauaagau ggauccaacg aagcaguaca aagugaugaa gacaaucccc     2700

cuguauaacc uaaccggucu gagcguuucc aaugggaaag accagcucgu gguauuccac     2760

acuaaggaua acaaagaccu gauugucugu cuuuuuagca agcaaccuac ccaugaaagu     2820

agaaucggcg aguugguggg agugcugguc aaucacuuca aaucugagaa gaggcacuua     2880

cagguuaacg ugacaaaucc aguacagugc agccuccaug gcaagaaaug caccgugucc     2940

gucgaaacuc ggcugaacca gccgcaaccc gauuuuacaa agaaucgauc aggguucauu     3000

cuuagcgugc cuggaaacug a                                               3021


<210>  2818
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1D__Homo_sapiens__AAI46764

<400>  2818
auggccgagc aggagagccu ggaguucggc aaggccgacu ucgugcugau ggacaccgug       60

agcaugcccg aguucauggc caaccugaga cugagauucg agaagggcag aaucuacacc      120

uucaucggcg aggugguggu gagcgugaac cccuacaagc ugcugaacau cuacggcaga      180

gacaccaucg agcaguacaa gggcagagag cuguacgaga gaccccccca ccuguucgcc      240

aucgccgacg ccgccuacaa ggccaugaag agaagaagca aggacaccug caucgugauc      300

agcggcgaga gcggcgccgg caagaccgag gccagcaagu acaucaugca guacaucgcc      360

gccaucacca accccagcca gagagccgag guggagagag ugaagaacau gcugcugaag      420

agcaacugcg ugcuggaggc cuucggcaac gccaagacca acagaaacga caacagcagc      480

agauucggca aguacaugga caucaacuuc gacuucaagg gcgaccccau cggcggccac      540

aucaacaacu accugcugga gaagagcaga gugaucgugc agcagcccgg cgagagaagc      600

uuccacagcu ucuaccagcu gcugcagggc ggcagcgagc agaugcugag aagccugcac      660

cugcagaaga gccugagcag cuacaacuac auccacgugg gcgcccagcu gaagagcagc      720

aucaacgacg ccgccgaguu cagaguggug gccgacgcca ugaaggugau cggcuucaag      780

cccgaggaga uccagaccgu guacaagauc cuggccgcca uccugcaccu gggcaaccug      840

aaguucgugg uggacggcga caccccccug aucgagaacg gcaagguggu gagcaucauc      900

gccgagcugc ugagcaccaa gaccgacaug guggagaagg cccugcugua cagaaccgug      960

gccaccggca gagacaucau cgacaagcag cacaccgagc aggaggccag cuacggcaga     1020

gacgccuucg ccaaggccau cuacgagaga cuguucugcu ggaucgugac cagaaucaac     1080

gacaucaucg aggugaagaa cuacgacacc accauccacg gcaagaacac cgugaucggc     1140

gugcuggaca ucuacggcuu cgagaucuuc gacaacaaca gcuucgagca guucugcauc     1200

aacuacugca acgagaagcu gcagcagcug uucauccagc uggugcugaa gcaggagcag     1260

gaggaguacc agagagaggg cauccccugg aagcacaucg acuacuucaa caaccagauc     1320

aucguggacc ugguggagca gcagcacaag ggcaucaucg ccauccugga cgacgccugc     1380

augaacgugg gcaaggugac cgacgagaug uuccuggagg cccugaacag caagcugggc     1440

aagcacgccc acuucagcag cagaaagcug ugcgccagcg acaagauccu ggaguucgac     1500

agagacuuca gaaucagaca cuacgccggc gacguggugu acagcgugau cggcuucauc     1560

gacaagaaca aggacacccu guuccaggac uucaagagac ugauguacaa cagcagcaac     1620

cccgugcuga agaacaugug gcccgagggc aagcugagca ucaccgaggu gaccaagaga     1680

ccccugaccg ccgccacccu guucaagaac agcaugaucg cccuggugga caaccuggcc     1740

agcaaggagc ccuacuacgu gagaugcauc aagcccaacg acaagaagag cccccagauc     1800

uucgacgacg agagaugcag acaccaggug gaguaccugg gccugcugga gaacgugaga     1860

gugagaagag ccggcuucgc cuucagacag accuacgaga aguuccugca cagauacaag     1920

augaucagcg aguucaccug gcccaaccac gaccugccca gcgacaagga ggccgugaag     1980

aagcugaucg agagaugcgg cuuccaggac gacguggccu acggcaagac caagaucuuc     2040

aucagaaccc ccagaacccu guucacccug gaggagcuga gagcccagau gcugaucaga     2100

aucgugcugu uccugcagaa gguguggaga ggcacccugg ccagaaugag auacaagaga     2160

accaaggccg cccugaccau caucagauac uacagaagau acaaggugaa gagcuacauc     2220

cacgaggugg ccagaagauu ccacggcgug aagaccauga gagacuacgg caagcacgug     2280

aaguggccca gcccccccaa ggugcugaga agauucgagg aggcccugca gaccaucuuc     2340

aacagaugga gagccagcca gcugaucaag agcauccccg ccagcgaccu gccccaggug     2400

agagccaagg uggccgccgu ggagaugcug aagggccaga gagccgaccu gggccugcag     2460

agagccuggg agggcaacua ccuggccagc aagcccgaca ccccccagac cagcggcacc     2520

uucgugcccg uggccaacga gcugaagaga aaggacaagu acaugaacgu gcuguucagc     2580

ugccacguga gaaaggugaa cagauucagc aagguggagg acagagccau cuucgugacc     2640

gacagacacc uguacaagau ggaccccacc aagcaguaca aggugaugaa gaccaucccc     2700

cuguacaacc ugaccggccu gagcgugagc aacggcaagg accagcuggu gguguuccac     2760

accaaggaca acaaggaccu gaucgugugc cuguucagca agcagcccac ccacgagagc     2820

agaaucggcg agcugguggg cgugcuggug aaccacuuca agagcgagaa gagacaccug     2880

caggugaacg ugaccaaccc cgugcagugc agccugcacg gcaagaagug caccgugagc     2940

guggagacca gacugaacca gccccagccc gacuucacca agaacagaag cggcuucauc     3000

cugagcgugc ccggcaacug a                                               3021


<210>  2819
<211>  3021
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1D__Homo_sapiens__AAI46764

<400>  2819
auggccgagc aggaaagccu ggaguucggc aaggcugacu uugugcucau ggauaccguc       60

uccaugcccg aguucauggc caaccugaga cuucgguuug agaaagggcg caucuacaca      120

uucauuggag aaguuguggu gucugucaau ccuuauaagc ugcucaacau cuacggcaga      180

gacacgauug agcaauauaa agggcgggag cuguacgaac gcccgcccca ccuuuuugcg      240

aucgcugaug ccgccuauaa ggcuaugaaa agacggagca aggauaccug cauugugauc      300

uccggagagu cuggcgccgg gaagacagaa gcuagcaaau acaucaugca guauauugcc      360

gcgaucacca auccuuccca gcgcgccgag guugagagag ugaagaacau gcugcucaaa      420

ucuaauugug uccuggaggc uuucggaaac gccaagacaa aucggaacga caauagcucc      480

cgcuuuggca aauacaugga cauuaacuuc gauuuuaagg gcgaccccau cgggggacau      540

auuaauaacu accugcucga aaagagcaga gugaucguuc agcaaccugg cgaacggucu      600

uuccacuccu uuuaucagcu gcuucaaggg ggaagcgagc agaugcugcg cucucuccau      660

cugcagaaau cccuuagcuc uuacaauuau auucacgugg gcgcucagcu gaaguccagc      720

aucaacgaug ccgcggaguu cagagucgug gccgacgcua ugaaagugau cggguuuaag      780

cccgaagaga uucagaccgu cuacaaaauc cucgccgcua uucugcaucu gggaaaucuc      840

aaguucguug uggauggcga cacaccucug aucgaaaacg gcaaaguggu cuccauuauc      900

gccgagcuuc ugucuaccaa gacggauaug guggaaaagg cccuccugua ucggaccguu      960

gcuacagggc gcgacaucau ugacaaacag cacaccgagc aagaagcgag cuacggaaga     1020

gaugccuucg cuaaggccau cuaugagcgg cuguuuugcu ggauugugac aagaaucaac     1080

gacauuaucg aggucaaaaa uuacgauacc acgauccacg gcaagaacac agugauuggg     1140

guucuggaca ucuacggauu cgaaauuuuu gauaauaacu ccuucgagca guuuuguauc     1200

aauuauugca acgaaaaacu ccagcaacug uucauucagc uggugcucaa gcaggagcag     1260

gaagaguacc aacgcgaggg caucccgugg aagcauauug acuauuuuaa uaaccagauc     1320

aucgucgauc ugguggaaca gcagcacaaa gggauuaucg ccauucuuga cgaugcuugu     1380

augaaugucg gaaaggugac cgacgagaug uuccuggaag cccucaacag caaacugggc     1440

aagcaugcgc acuuuucuuc ccggaaacuu ugcgcuagcg auaagauccu ggaguucgac     1500

agagacuuuc gcauucggca cuacgccggc gauguugugu auucugucau cggguucauc     1560

gacaagaaua aagauacacu cuuucaagac uucaagagac ugauguacaa cagcuccaau     1620

cccgugcuga aaaacaugug gccugaggga aagcucucua uuaccgaagu uaccaaacgc     1680

ccccugacag ccgcuacgcu uuucaagaau agcaugaucg cccuggugga uaaccucgcu     1740

uccaaggagc cuuauuacgu ccgguguauu aaacccaacg acaagaaaag cccgcagauc     1800

uuugaugacg aaagaugccg ccaucaggug gaguaccugg gccugcuuga aaaugugcgg     1860

guuagacgcg ccggguucgc guuucggcag accuaugaga aguuccucca cagauacaaa     1920

augauuucug aguuuacaug gccuaaccau gaucugcccu ccgacaagga agccgucaaa     1980

aagcugaucg agcggugugg auuccaagau gacguggcuu auggcaagac caaaaucuuu     2040

auucgcacac cuagaacccu cuucacgcug gaagaacuuc gggcccagau gcugaucaga     2100

auugugcucu uucugcagaa ggucuggcgc gggacacugg cucggaugag auacaaacgc     2160

accaaggccg cgcuuaccau cauuagauau uaccggcgcu auaaaguuaa gagcuacauc     2220

cacgaagugg ccagacgguu ccauggcgug aagacaaugc gcgauuacgg aaaacacguc     2280

aaguggcccu cucccccuaa agugcucaga cgguuugagg aggcucugca gaccaucuuc     2340

aaucgcugga gagccuccca acugauuaag agcaucccgg cuuccgaccu cccccagguu     2400

cgggccaaag uggccgcugu cgaaaugcug aagggccagc gcgcggaccu ugggcugcaa     2460

agagccuggg agggaaacua ucucgcuucu aagccugaua caccccagac gagcggcacc     2520

uuugugccug uugccaauga acugaaacgg aaggacaaau acaugaacgu gcuguucucc     2580

ugccacguca gaaaggugaa ucgcuucucu aaaguggagg aucgggccau uuuugucaca     2640

gacagacauc uuuauaagau ggaucccacc aagcaguaca aaguuaugaa gacaaucccg     2700

cucuauaacc ugaccgggcu gagcgugucc aauggaaaag accagcucgu ggucuuccac     2760

acgaaggaua acaaagaccu gauugugugu cuuuuuagca agcaaccuac ccaugaaucu     2820

cgcaucggcg agcugguugg ggugcucguc aaucacuuca aauccgagaa gcggcaccuu     2880

caggugaacg uuacaaaucc cgugcagugc agccugcaug gcaagaaaug caccgucucu     2940

guggaaacaa gacuuaacca gccucaaccc gauuuuacca agaaucgcuc cggauucauu     3000

cucagcguuc cuggcaacug a                                               3021


<210>  2820
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1E__Homo_sapiens__Q12965

<400>  2820

Met Gly Ser Lys Gly Val Tyr Gln Tyr His Trp Gln Ser His Asn Val 
1               5                   10                  15      


Lys His Ser Gly Val Asp Asp Met Val Leu Leu Ser Lys Ile Thr Glu 
            20                  25                  30          


Asn Ser Ile Val Glu Asn Leu Lys Lys Arg Tyr Met Asp Asp Tyr Ile 
        35                  40                  45              


Phe Thr Tyr Ile Gly Ser Val Leu Ile Ser Val Asn Pro Phe Lys Gln 
    50                  55                  60                  


Met Pro Tyr Phe Gly Glu Lys Glu Ile Glu Met Tyr Gln Gly Ala Ala 
65                  70                  75                  80  


Gln Tyr Glu Asn Pro Pro His Ile Tyr Ala Leu Ala Asp Asn Met Tyr 
                85                  90                  95      


Arg Asn Met Ile Ile Asp Arg Glu Asn Gln Cys Val Ile Ile Ser Gly 
            100                 105                 110         


Glu Ser Gly Ala Gly Lys Thr Val Ala Ala Lys Tyr Ile Met Ser Tyr 
        115                 120                 125             


Ile Ser Arg Val Ser Gly Gly Gly Thr Lys Val Gln His Val Lys Asp 
    130                 135                 140                 


Ile Ile Leu Gln Ser Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys 
145                 150                 155                 160 


Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Tyr Phe Glu Ile 
                165                 170                 175     


Gln Phe Ser Pro Gly Gly Glu Pro Asp Gly Gly Lys Ile Ser Asn Phe 
            180                 185                 190         


Leu Leu Glu Lys Ser Arg Val Val Met Arg Asn Pro Gly Glu Arg Ser 
        195                 200                 205             


Phe His Ile Phe Tyr Gln Leu Ile Glu Gly Ala Ser Ala Glu Gln Lys 
    210                 215                 220                 


His Ser Leu Gly Ile Thr Ser Met Asp Tyr Tyr Tyr Tyr Leu Ser Leu 
225                 230                 235                 240 


Ser Gly Ser Tyr Lys Val Asp Asp Ile Asp Asp Arg Arg Glu Phe Gln 
                245                 250                 255     


Glu Thr Leu His Ala Met Asn Val Ile Gly Ile Phe Ala Glu Glu Gln 
            260                 265                 270         


Thr Leu Val Leu Gln Ile Val Ala Gly Ile Leu His Leu Gly Asn Ile 
        275                 280                 285             


Ser Phe Lys Glu Val Gly Asn Tyr Ala Ala Val Glu Ser Glu Glu Phe 
    290                 295                 300                 


Leu Ala Phe Pro Ala Tyr Leu Leu Gly Ile Asn Gln Asp Arg Leu Lys 
305                 310                 315                 320 


Glu Lys Leu Thr Ser Arg Gln Met Asp Ser Lys Trp Gly Gly Lys Ser 
                325                 330                 335     


Glu Ser Ile His Val Thr Leu Asn Val Glu Gln Ala Cys Tyr Thr Arg 
            340                 345                 350         


Asp Ala Leu Ala Lys Ala Leu His Ala Arg Val Phe Asp Phe Leu Val 
        355                 360                 365             


Asp Ser Ile Asn Lys Ala Met Glu Lys Asp His Glu Glu Tyr Asn Ile 
    370                 375                 380                 


Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn Gly Phe 
385                 390                 395                 400 


Glu Gln Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln Ile Phe 
                405                 410                 415     


Ile Glu Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln Glu Gly 
            420                 425                 430         


Ile Arg Trp Thr Pro Ile Glu Tyr Phe Asn Asn Lys Ile Val Cys Asp 
        435                 440                 445             


Leu Ile Glu Asn Lys Val Asn Pro Pro Gly Ile Met Ser Ile Leu Asp 
    450                 455                 460                 


Asp Val Cys Ala Thr Met His Ala Val Gly Glu Gly Ala Asp Gln Thr 
465                 470                 475                 480 


Leu Leu Gln Lys Leu Gln Met Gln Ile Gly Ser His Glu His Phe Asn 
                485                 490                 495     


Ser Trp Asn Gln Gly Phe Ile Ile His His Tyr Ala Gly Lys Val Ser 
            500                 505                 510         


Tyr Asp Met Asp Gly Phe Cys Glu Arg Asn Arg Asp Val Leu Phe Met 
        515                 520                 525             


Asp Leu Ile Glu Leu Met Gln Ser Ser Glu Leu Pro Phe Ile Lys Ser 
    530                 535                 540                 


Leu Phe Pro Glu Asn Leu Gln Ala Asp Lys Lys Gly Arg Pro Thr Thr 
545                 550                 555                 560 


Ala Gly Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ser Thr Leu 
                565                 570                 575     


Met Lys Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Glu Thr 
            580                 585                 590         


Lys Lys Pro Arg Asp Trp Glu Glu Ser Arg Val Lys His Gln Val Glu 
        595                 600                 605             


Tyr Leu Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly Tyr Ala 
    610                 615                 620                 


Tyr Arg Arg Ile Phe Gln Lys Phe Leu Gln Arg Tyr Ala Ile Leu Thr 
625                 630                 635                 640 


Lys Ala Thr Trp Pro Ser Trp Gln Gly Glu Glu Lys Gln Gly Val Leu 
                645                 650                 655     


His Leu Leu Gln Ser Val Asn Met Asp Ser Asp Gln Phe Gln Leu Gly 
            660                 665                 670         


Arg Ser Lys Val Phe Ile Lys Ala Pro Glu Ser Leu Phe Leu Leu Glu 
        675                 680                 685             


Glu Met Arg Glu Arg Lys Tyr Asp Gly Tyr Ala Arg Val Ile Gln Lys 
    690                 695                 700                 


Ser Trp Arg Lys Phe Val Ala Arg Lys Lys Tyr Val Gln Met Arg Glu 
705                 710                 715                 720 


Glu Ala Ser Asp Leu Leu Leu Asn Lys Lys Glu Arg Arg Arg Asn Ser 
                725                 730                 735     


Ile Asn Arg Asn Phe Ile Gly Asp Tyr Ile Gly Met Glu Glu His Pro 
            740                 745                 750         


Glu Leu Gln Gln Phe Val Gly Lys Arg Glu Lys Ile Asp Phe Ala Asp 
        755                 760                 765             


Thr Val Thr Lys Tyr Asp Arg Arg Phe Lys Gly Val Lys Arg Asp Leu 
    770                 775                 780                 


Leu Leu Thr Pro Lys Cys Leu Tyr Leu Ile Gly Arg Glu Lys Val Lys 
785                 790                 795                 800 


Gln Gly Pro Asp Lys Gly Leu Val Lys Glu Val Leu Lys Arg Lys Ile 
                805                 810                 815     


Glu Ile Glu Arg Ile Leu Ser Val Ser Leu Ser Thr Met Gln Asp Asp 
            820                 825                 830         


Ile Phe Ile Leu His Glu Gln Glu Tyr Asp Ser Leu Leu Glu Ser Val 
        835                 840                 845             


Phe Lys Thr Glu Phe Leu Ser Leu Leu Ala Lys Arg Tyr Glu Glu Lys 
    850                 855                 860                 


Thr Gln Lys Gln Leu Pro Leu Lys Phe Ser Asn Thr Leu Glu Leu Lys 
865                 870                 875                 880 


Leu Lys Lys Glu Asn Trp Gly Pro Trp Ser Ala Gly Gly Ser Arg Gln 
                885                 890                 895     


Val Gln Phe His Gln Gly Phe Gly Asp Leu Ala Val Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Val Leu Gln Val Ser Ile Gly Pro Gly Leu Pro Lys Asn Ser 
        915                 920                 925             


Arg Pro Thr Arg Arg Asn Thr Thr Gln Asn Thr Gly Tyr Ser Ser Gly 
    930                 935                 940                 


Thr Gln Asn Ala Asn Tyr Pro Val Arg Ala Ala Pro Pro Pro Pro Gly 
945                 950                 955                 960 


Tyr His Gln Asn Gly Val Ile Arg Asn Gln Tyr Val Pro Tyr Pro His 
                965                 970                 975     


Ala Pro Gly Ser Gln Arg Ser Asn Gln Lys Ser Leu Tyr Thr Ser Met 
            980                 985                 990         


Ala Arg Pro Pro Leu Pro Arg Gln Gln Ser Thr Ser Ser Asp Arg Val 
        995                 1000                1005            


Ser Gln Thr Pro Glu Ser Leu Asp Phe Leu Lys Val Pro Asp Gln Gly 
    1010                1015                1020                


Ala Ala Gly Val Arg Arg Gln Thr Thr Ser Arg Pro Pro Pro Ala Gly 
1025                1030                1035                1040


Gly Arg Pro Lys Pro Gln Pro Lys Pro Lys Pro Gln Val Pro Gln Cys 
                1045                1050                1055    


Lys Ala Leu Tyr Ala Tyr Asp Ala Gln Asp Thr Asp Glu Leu Ser Phe 
            1060                1065                1070        


Asn Ala Asn Asp Ile Ile Asp Ile Ile Lys Glu Asp Pro Ser Gly Trp 
        1075                1080                1085            


Trp Thr Gly Arg Leu Arg Gly Lys Gln Gly Leu Phe Pro Asn Asn Tyr 
    1090                1095                1100                


Val Thr Lys Ile 
1105            


<210>  2821
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1E__Homo_sapiens__CCDS32254.1

<400>  2821
augggaagca aaggugucua ccaguaccac uggcaaagcc acaaugucaa gcacaguggu       60

guggacgaca uggugcuacu guccaagauc acagagaacu ccaucgugga gaaucugaag      120

aagagauaca uggaugacua cauuuuuaca uauauaggau cuguauuaau cucagucaac      180

ccuuucaagc agaugccaua uuuuggggaa aaggaaauug aaauguacca aggagcggca      240

caguaugaaa acccaccaca uaucuaugcc cuugcagaua auauguacag aaacaugauc      300

auugacagag agaaccagug cgucauuauc aguggugaaa guggugcugg aaaaacagug      360

gcugccaaau auaucaugag cuacaucucc agagugucug gaggagggac caaaguccag      420

cacgugaagg acauuauccu gcaguccaac ccgcugcugg aggccuucgg gaacgccaag      480

accguccgga acaacaacuc cagccgauuu ggaaaauacu uugaaaucca guucagucca      540

gguggggaac cagauggugg aaagaucucc aacuuccuuc uggaaaaauc uaggguggug      600

augaggaacc caggagagcg gaguuuucac auauuuuacc agcucaucga gggcgccucu      660

gcagagcaga aacacagccu uggcaucacc agcauggacu auuauuacua ccugagccuc      720

ucgggcucau acaagguuga ugacauugac gacaggcggg aguuucagga aacucugcac      780

gccaugaaug ugauugggau cuuugcagaa gagcaaacgc ugguguugca gauaguggcg      840

gguauucucc accugggaaa caucagcuuc aaagaaguug gcaacuacgc ggcuguggag      900

agugaagagu uuuuagcuuu uccugcauau cugcuaggga uaaaccagga ccgguugaaa      960

gaaaagcuaa caagccggca gauggauagc aaguggggag gcaaauccga auccauccac     1020

gugacccuca acguagagca ggccuguuac acccgggaug cgcucgccaa ggcccugcac     1080

gcccgggucu uugauuucuu gguagauucc aucaauaaag ccauggagaa agaccaugaa     1140

gaauacaaca uuggcguccu agacaucuau ggcuuugaaa uauuccagaa aaauggcuuu     1200

gaacaguuuu guaucaauuu uguuaaugaa aaacugcagc agauuuuuau ugaacugaca     1260

uuaaaggcag aacaggaaga auauguucaa gagggaauaa gauggacacc cauugaguac     1320

uuuaauaaua aaaucguaug ugaccucaua gagaacaaag ugaacccucc uggcaucaug     1380

agcauccugg augacgugug cgccacgaug caugcggugg gugagggggc agaucagacg     1440

cugcuccaga aacuucagau gcagauuggg agucaugagc acuucaacag uuggaaccaa     1500

ggcuucauca uucaucauua ugcugggaag guauccuaug acauggaugg cuuuugugaa     1560

aggaaccggg augugcuuuu uauggaucuc aucgagcuua ugcagagcag cgagcugccu     1620

uucauaaagu cuuuauuucc ggaaaaucug caggcugaca agaaagggcg cccaacuacu     1680

gccggaagca aaauaaagaa acaagccaau gaccuuguga gcacccugau gaaauguacg     1740

ccccacuaca uucgcugcau caagccaaac gaaaccaaga agcccagaga cugggaggaa     1800

agcaggguaa agcaucaagu cgaauauuug ggucugaaag agaacauucg agugagaaga     1860

gcuggcuaug ccuaucggcg caucuuccaa aaauuccuac agagguaugc cauucugacc     1920

aaagccaccu ggccuucuug gcagggagag gagaagcaag gcguccugca ccugcugcag     1980

ucggucaaca uggacagcga ccaguuccag cuggggagga guaaaguguu caucaaagcc     2040

cccgagucuc uauuucuuuu agaagagaug agagagagaa aguaugaugg guaugcucga     2100

gugauacaga aaucauggag gaaauucgug gcccggaaga aauacguuca aaugagagaa     2160

gaagccucag accucuuauu gaacaagaag gagagaagga gaaacaguau uaacaggaac     2220

uuuauagggg auuauauugg gauggaagag cacccagaac uccagcaguu cgugggcaag     2280

agggagaaga uugauuucgc agacacaguc accaaguaug acaggagguu caagggugua     2340

aagcgagacc ugcuccuuac cccaaagugc uuguacuuaa ucggacgaga aaaagucaaa     2400

cagggcccag acaagggccu ggugaaagaa guccugaagc ggaaaaucga gauagaacgg     2460

aucuugucug ugucccucag uacuaugcag gaugacauuu uuauucucca ugagcaagag     2520

uaugacaguu ugcuugaauc ugucuucaaa acugaauucc uaagccucuu agcaaagcgu     2580

uacgaggaga agacccagaa gcaacuaccu cugaaauuca gcaauacgcu ugaacugaag     2640

uugaaaaagg aaaacugggg ccccuggagu gcagggggcu cccggcaagu gcaguuccac     2700

caaggguuug gggaccuggc uguccucaag cccaguaaca aagugcugca ggucagcauc     2760

ggaccuggac ugcccaagaa cucccguccu accagaagga acacuaccca aaauacaggu     2820

uauuccagug ggacucaaaa ugccaacuac ccagugagag cugccccucc ucccccagga     2880

uaccaucaga acggagucau cagaaaccag uaugugccau auccccaugc uccuggaagc     2940

cagaggucca aucagaaaag ccuguacacc uccauggccc gcccgcccuu gccucggcag     3000

cagucuacca guucagaccg agugucacag acgccagaga gccuggauuu ccucaagguc     3060

ccggaccagg gagcugcagg ggucaggaga caaacaacca gucggccucc cccagcaggg     3120

ggcagaccca agccccagcc caagcccaag ccucaggugc cacagugcaa ggcuuuguau     3180

gccuaugacg cucaggacac agacgaacuc agcuuuaaug ccaaugacau uauugauauu     3240

aucaaagaag auccuucugg cugguggacg ggucgacuac gaggcaagca gggccuguuc     3300

cccaacaacu augugaccaa gaucuga                                         3327


<210>  2822
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1E__Homo_sapiens__CCDS32254.1

<400>  2822
augggcagca agggggugua ccaguaccac uggcaguccc acaacgucaa gcacagcggc       60

guggacgaca uggugcugcu cuccaagauc accgagaaca gcaucgucga gaaccugaag      120

aagcgcuaca uggacgacua caucuucacc uacaucgggu ccgugcugau cagcgugaac      180

cccuucaagc agaugccgua cuucggcgag aaggagaucg agauguacca gggggccgcc      240

caguacgaga acccccccca caucuacgcg cucgccgaca acauguaccg gaacaugauc      300

aucgaccgcg agaaccagug cgucaucauc uccggcgaga gcggcgccgg gaagacggug      360

gccgccaagu acaucauguc cuacaucagc cggguguccg gcgggggcac caagguccag      420

cacgugaagg acaucauccu gcagagcaac ccccugcucg aggcguucgg gaacgccaag      480

accgugcgca acaacaacuc cagccgguuc ggcaaguacu ucgagaucca guucuccccg      540

ggcggggagc ccgacggcgg gaagaucagc aacuuccugc uggagaaguc ccgcgucgug      600

augcggaacc ccggcgagcg cagcuuccac aucuucuacc agcucaucga gggcgccucc      660

gccgagcaga agcacagccu ggggaucacc agcauggacu acuacuacua ccugucccuc      720

agcggcuccu acaaggugga cgacaucgac gaccggcgcg aguuccagga gacgcugcac      780

gcgaugaacg ucaucgggau cuucgccgag gagcagaccc uggugcucca gaucguggcc      840

ggcauccugc accuggggaa caucagcuuc aaggaggucg gcaacuacgc cgccguggag      900

uccgaggagu uccucgcguu ccccgccuac cugcugggca ucaaccagga ccggcucaag      960

gagaagcuga ccagccgcca gauggacucc aagugggggg gcaagagcga guccauccac     1020

gugacccuga acgucgagca ggccugcuac acgcgggacg cccucgccaa ggcgcugcac     1080

gcccgcgugu ucgacuuccu gguggacagc aucaacaagg ccauggagaa ggaccacgag     1140

gaguacaaca ucgggguccu cgacaucuac ggcuucgaga ucuuccagaa gaacggguuc     1200

gagcaguucu gcaucaacuu cgugaacgag aagcugcagc agaucuucau cgagcugacc     1260

cucaaggccg agcaggagga guacguccag gagggcaucc gguggacccc gaucgaguac     1320

uucaacaaca agaucgugug cgaccugauc gagaacaagg ugaacccccc cggcaucaug     1380

uccauccugg acgacgucug cgccaccaug cacgcggugg gggagggcgc cgaccagacg     1440

cuccugcaga agcugcagau gcagaucggg agccacgagc acuucaacuc cuggaaccag     1500

ggcuucauca uccaccacua cgccgggaag gugagcuacg acauggacgg cuucugcgag     1560

cgcaaccggg acguccucuu cauggaccug aucgagcuga ugcaguccag cgagcucccc     1620

uucaucaagu cccuguuccc ggagaaccug caggccgaca agaagggccg ccccaccacc     1680

gccgggagca agaucaagaa gcaggcgaac gaccucgugu ccacccugau gaagugcacg     1740

ccccacuaca uccggugcau caagcccaac gagaccaaga agccgcgcga cugggaggag     1800

agccggguga agcaccaggu cgaguaccug ggccucaagg agaacauccg cgugcgccgg     1860

gccggguacg ccuaccgccg gaucuuccag aaguuccugc agcgcuacgc cauccugacc     1920

aaggcgaccu ggcccagcug gcagggcgag gagaagcagg gcgugcucca ccugcugcag     1980

uccgucaaca uggacagcga ccaguuccag cuggggcggu ccaagguguu caucaaggcc     2040

cccgagagcc ucuuccugcu ggaggagaug cgcgagcgga aguacgacgg cuacgcccgc     2100

gugauccaga aguccuggcg gaaguucguc gcccgcaaga aguacgugca gaugcgggag     2160

gaggccagcg accuccugcu gaacaagaag gagcgccggc gcaacuccau caaccggaac     2220

uucaucgggg acuacaucgg cauggaggag caccccgagc uccagcaguu cguggggaag     2280

cgcgagaaga ucgacuucgc ggacacgguc accaaguacg accggcgcuu caagggcgug     2340

aagcgggacc ugcugcucac cccgaagugc cuguaccuga ucggccgcga gaaggugaag     2400

caggggcccg acaagggccu cgucaaggag gugcugaagc gcaagaucga gaucgagcgg     2460

auccugagcg ugucccucag caccaugcag gacgacaucu ucauccugca cgagcaggag     2520

uacgacuccc ugcucgagag cgucuucaag acggaguucc ugucccugcu cgccaagcgc     2580

uacgaggaga agacccagaa gcagcugccc cugaaguuca gcaacacccu cgagcugaag     2640

cugaagaagg agaacugggg gcccuggucc gccggcggga gccggcaggu gcaguuccac     2700

cagggcuucg gcgaccucgc cgugcugaag ccguccaaca agguccugca ggugagcauc     2760

gggcccggcc uccccaagaa cagccgcccc acccggcgca acacgaccca gaacaccggg     2820

uacuccagcg gcacccagaa cgccaacuac ccggugcggg cggccccccc cccgcccggg     2880

uaccaccaga acggcgucau ccgcaaccag uacgugcccu acccccacgc cccgggcucc     2940

cagcggagca accagaaguc ccuguacacg agcauggccc gccccccccu gccccggcag     3000

caguccacca gcuccgaccg cgugagccag accccggagu cccucgacuu ccugaagguc     3060

cccgaccagg gggccgcggg cgugcggcgc cagaccacga gccggccccc cccggccggg     3120

ggccgcccca agccccagcc caagccgaag ccccaggugc cccagugcaa ggcccuguac     3180

gccuacgacg cgcaggacac cgacgagcuc uccuucaacg ccaacgacau caucgacauc     3240

aucaaggagg accccagcgg gugguggacc ggccggcugc gcggcaagca ggggcuguuc     3300

ccgaacaacu acgucaccaa gaucuga                                         3327


<210>  2823
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1E__Homo_sapiens__CCDS32254.1

<400>  2823
augggcucca agggcgucua ccaguaccac uggcaguccc acaacgucaa gcacuccggc       60

gucgacgaca ugguccuccu cuccaagauc accgagaacu ccaucgucga gaaccucaag      120

aagcgcuaca uggacgacua caucuucacc uacaucggcu ccguccucau cuccgucaac      180

cccuucaagc agaugcccua cuucggcgag aaggagaucg agauguacca gggcgccgcc      240

caguacgaga acccccccca caucuacgcc cucgccgaca acauguaccg caacaugauc      300

aucgaccgcg agaaccagug cgucaucauc uccggcgagu ccggcgccgg caagaccguc      360

gccgccaagu acaucauguc cuacaucucc cgcgucuccg gcggcggcac caagguccag      420

cacgucaagg acaucauccu ccaguccaac ccccuccucg aggccuucgg caacgccaag      480

accguccgca acaacaacuc cucccgcuuc ggcaaguacu ucgagaucca guucuccccc      540

ggcggcgagc ccgacggcgg caagaucucc aacuuccucc ucgagaaguc ccgcgucguc      600

augcgcaacc ccggcgagcg cuccuuccac aucuucuacc agcucaucga gggcgccucc      660

gccgagcaga agcacucccu cggcaucacc uccauggacu acuacuacua ccucucccuc      720

uccggcuccu acaaggucga cgacaucgac gaccgccgcg aguuccagga gacccuccac      780

gccaugaacg ucaucggcau cuucgccgag gagcagaccc ucguccucca gaucgucgcc      840

ggcauccucc accucggcaa caucuccuuc aaggaggucg gcaacuacgc cgccgucgag      900

uccgaggagu uccucgccuu ccccgccuac cuccucggca ucaaccagga ccgccucaag      960

gagaagcuca ccucccgcca gauggacucc aaguggggcg gcaaguccga guccauccac     1020

gucacccuca acgucgagca ggccugcuac acccgcgacg cccucgccaa ggcccuccac     1080

gcccgcgucu ucgacuuccu cgucgacucc aucaacaagg ccauggagaa ggaccacgag     1140

gaguacaaca ucggcguccu cgacaucuac ggcuucgaga ucuuccagaa gaacggcuuc     1200

gagcaguucu gcaucaacuu cgucaacgag aagcuccagc agaucuucau cgagcucacc     1260

cucaaggccg agcaggagga guacguccag gagggcaucc gcuggacccc caucgaguac     1320

uucaacaaca agaucgucug cgaccucauc gagaacaagg ucaacccccc cggcaucaug     1380

uccauccucg acgacgucug cgccaccaug cacgccgucg gcgagggcgc cgaccagacc     1440

cuccuccaga agcuccagau gcagaucggc ucccacgagc acuucaacuc cuggaaccag     1500

ggcuucauca uccaccacua cgccggcaag gucuccuacg acauggacgg cuucugcgag     1560

cgcaaccgcg acguccucuu cauggaccuc aucgagcuca ugcaguccuc cgagcucccc     1620

uucaucaagu cccucuuccc cgagaaccuc caggccgaca agaagggccg ccccaccacc     1680

gccggcucca agaucaagaa gcaggccaac gaccucgucu ccacccucau gaagugcacc     1740

ccccacuaca uccgcugcau caagcccaac gagaccaaga agccccgcga cugggaggag     1800

ucccgcguca agcaccaggu cgaguaccuc ggccucaagg agaacauccg cguccgccgc     1860

gccggcuacg ccuaccgccg caucuuccag aaguuccucc agcgcuacgc cauccucacc     1920

aaggccaccu ggcccuccug gcagggcgag gagaagcagg gcguccucca ccuccuccag     1980

uccgucaaca uggacuccga ccaguuccag cucggccgcu ccaaggucuu caucaaggcc     2040

cccgaguccc ucuuccuccu cgaggagaug cgcgagcgca aguacgacgg cuacgcccgc     2100

gucauccaga aguccuggcg caaguucguc gcccgcaaga aguacgucca gaugcgcgag     2160

gaggccuccg accuccuccu caacaagaag gagcgccgcc gcaacuccau caaccgcaac     2220

uucaucggcg acuacaucgg cauggaggag caccccgagc uccagcaguu cgucggcaag     2280

cgcgagaaga ucgacuucgc cgacaccguc accaaguacg accgccgcuu caagggcguc     2340

aagcgcgacc uccuccucac ccccaagugc cucuaccuca ucggccgcga gaaggucaag     2400

cagggccccg acaagggccu cgucaaggag guccucaagc gcaagaucga gaucgagcgc     2460

auccucuccg ucucccucuc caccaugcag gacgacaucu ucauccucca cgagcaggag     2520

uacgacuccc uccucgaguc cgucuucaag accgaguucc ucucccuccu cgccaagcgc     2580

uacgaggaga agacccagaa gcagcucccc cucaaguucu ccaacacccu cgagcucaag     2640

cucaagaagg agaacugggg ccccuggucc gccggcggcu cccgccaggu ccaguuccac     2700

cagggcuucg gcgaccucgc cguccucaag cccuccaaca agguccucca ggucuccauc     2760

ggccccggcc uccccaagaa cucccgcccc acccgccgca acaccaccca gaacaccggc     2820

uacuccuccg gcacccagaa cgccaacuac cccguccgcg ccgccccccc cccccccggc     2880

uaccaccaga acggcgucau ccgcaaccag uacguccccu acccccacgc ccccggcucc     2940

cagcgcucca accagaaguc ccucuacacc uccauggccc gccccccccu cccccgccag     3000

caguccaccu ccuccgaccg cgucucccag acccccgagu cccucgacuu ccucaagguc     3060

cccgaccagg gcgccgccgg cguccgccgc cagaccaccu cccgcccccc ccccgccggc     3120

ggccgcccca agccccagcc caagcccaag ccccaggucc cccagugcaa ggcccucuac     3180

gccuacgacg cccaggacac cgacgagcuc uccuucaacg ccaacgacau caucgacauc     3240

aucaaggagg accccuccgg cugguggacc ggccgccucc gcggcaagca gggccucuuc     3300

cccaacaacu acgucaccaa gaucuga                                         3327


<210>  2824
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1E__Homo_sapiens__CCDS32254.1

<400>  2824
augggcagca agggggugua ccaguaucac uggcaauccc auaacgucaa acacucugga       60

guugacgaua uggugcugcu cucaaagauc accgagaaua guauuguaga aaaccuuaaa      120

aagagauaca uggacgauua uauauucaca uacaucggua gcgugcugau uuccgucaau      180

cccuuuaaac agaugccuua uuucggcgag aaggaaaucg agauguacca gggggccgcu      240

caguaugaaa acccaccgca uauuuacgca uuggccgaca auauguacag gaacaugauc      300

auagaucggg agaaucaaug cgugaucauu ucuggagagu cgggcgcggg uaagacuguu      360

gcugccaaau auaucauguc auacauuagc cgcgugagug ggggaggcac gaagguccag      420

cacgugaaag acaucauauu acaguccaac ccccugcuag aagcauuugg caaugccaag      480

accguacgaa acaauaacuc uagccguuuc gggaaauauu uugagauuca guucuccccu      540

ggaggugaac cagauggcgg gaagaucuca aauuuucucc uggagaagag uagaguugug      600

augaggaacc ccggagagcg gagcuuccau auuuucuacc aacuuaucga aggcgcuucu      660

gcagagcaga aacacucccu ggguaucaca ucaauggacu auuacuauua cuugagccuc      720

agugggucuu acaaggucga ugacauugau gaccgcagag aauuucagga gacucugcac      780

gccaugaaug ugauaggaau cuuugcugag gaacagaccc uggugcucca aauugucgcc      840

ggcaucuuac aucugggcaa cauauccuuc aaagagguug ggaacuaugc ggcaguggaa      900

agcgaggaau uucuugccuu cccugcuuac uugcugggaa uuaaucagga uaggcuaaag      960

gagaaacuca caucgcggca gauggacucu aaguggggug gcaaauccga aucaauccac     1020

guaacccuga acguggagca agccuguuau acucgcgacg cacuugcuaa ggcccugcau     1080

gcgcgagucu ucgauuuucu cguggacagu aucaauaagg ccauggagaa agaucacgaa     1140

gaguacaaca uugggguucu cgacaucuau ggauucgaaa uuuuucagaa gaauggcuuc     1200

gagcaguuuu gcauaaacuu cgugaaugaa aaacugcagc aaaucuuuau ugaguuaaca     1260

cugaaggcag agcaggaaga guacguccag gaagguauca gauggacccc aaucgaguau     1320

uucaacaaua aaauugugug ugaucucaua gagaacaagg uaaauccccc ugggaucaug     1380

agcauucuug acgauguuug cgcuacgaug cacgccgugg gcgaaggagc ugaccagacu     1440

cuguugcaaa agcuacagau gcagaucggc ucccaugagc acuuuaacuc uuggaaucag     1500

ggguucauua uccaucacua cgccggaaaa gucagcuacg auauggacgg uuuuugugaa     1560

aggaaccggg augugcuguu cauggaccuc auagagcuga ugcaaucaag ugaacuucca     1620

uuuaucaagu cccuguuccc ggagaauuug caggcagaca aaaagggccg ucccaccaca     1680

gccgggagca aaauuaagaa gcaggcuaac gaucucgucu cuacucugau gaaaugcacc     1740

ccucauuaua uccgcuguau uaagccaaac gagaccaaaa agcccagaga cugggaagag     1800

ucaaggguga aacaccaggu ugaauacuua ggacugaagg agaauauccg ggugcgacgc     1860

gcgggcuaug cauacagaag gauauuccaa aaguuucuac agcgguaugc cauucucaca     1920

aaagcuacgu ggccuaguug gcagggugaa gagaagcaag ggguacugca ccuuuugcag     1980

agcgucaaca uggauuccga ccaguuccag cugggccgcu cuaaaguguu uaucaaggcc     2040

ccagagucgu uguuccugcu ugaagagaug agagaaagga aauacgaugg auaugcacgu     2100

guuauucaaa agagcuggcg gaaauuugug gcccgaaaga aguacgucca gaugagagag     2160

gaggcuuccg accuguugcu caauaaaaag gaaaggcgcc ggaacucaau caauagaaac     2220

uucauaggcg auuacaucgg gauggaggaa caucccgagc ugcagcaguu ugugggaaaa     2280

agggaaaaga uugacuucgc cgauacugua acaaaauaug accgccgauu uaagggugug     2340

aagcgggauu uacugcuaac cccgaaaugc cucuaccuga ucggccguga gaagguuaaa     2400

caagggccug acaagggacu ugucaaagag guguugaaga gaaagauuga aaucgagagg     2460

auacugagug ugucucucag cacuaugcag gaugacauuu ucauccugca cgaacaggag     2520

uaugacuccu uacuggaauc agucuuuaaa acagaguucc uuagcuugcu cgcaaagcgc     2580

uacgaggaga aaacccagaa gcaacugccc cuaaaauuuu cuaauacgcu ggaacucaag     2640

cugaagaaag aaaacugggg cccauggucc gcggguggga gucggcaggu ucaguuccau     2700

caaggcuucg gagaucuugc uguguugaag ccuagcaaua aagugcugca gguaucuauc     2760

ggccccgggu uaccaaagaa cuccagaccc accaggcgaa auacaacuca gaacaccgga     2820

uauucaagug gcacacagaa ugccaacuac ccuguccgcg cagccccacc gcccccuggu     2880

uaucaccaaa auggggugau ucggaaccag uacguuccau acccccacgc uccuggaagc     2940

cagagaucga accagaaauc ccucuauacu ucuauggcca ggccaccccu gccgcgucaa     3000

cagagcaccu caagugaccg cgugucccag acaccugagu cucuugauuu ucugaagguc     3060

ccagaccagg gcgcagcugg ugugcggaga caaaccacua gcaggccccc ucccgccggc     3120

gggcgaccaa aaccucagcc caagccaaag ccgcagguuc cucaguguaa agcguuguac     3180

gccuaugaug cucaagacac ggaugaacuc uccuucaaug caaacgacau cauugauaua     3240

aucaaggagg accccucagg augguggaca ggccggcugc gcgggaaaca gggacuauuu     3300

ccaaauaacu acgugaccaa gauuuga                                         3327


<210>  2825
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1E__Homo_sapiens__CCDS32254.1

<400>  2825
augggcagca agggcgugua ccaguaccac uggcagagcc acaacgugaa gcacagcggc       60

guggacgaca uggugcugcu gagcaagauc accgagaaca gcaucgugga gaaccugaag      120

aagagauaca uggacgacua caucuucacc uacaucggca gcgugcugau cagcgugaac      180

cccuucaagc agaugcccua cuucggcgag aaggagaucg agauguacca gggcgccgcc      240

caguacgaga acccccccca caucuacgcc cuggccgaca acauguacag aaacaugauc      300

aucgacagag agaaccagug cgugaucauc agcggcgaga gcggcgccgg caagaccgug      360

gccgccaagu acaucaugag cuacaucagc agagugagcg gcggcggcac caaggugcag      420

cacgugaagg acaucauccu gcagagcaac ccccugcugg aggccuucgg caacgccaag      480

accgugagaa acaacaacag cagcagauuc ggcaaguacu ucgagaucca guucagcccc      540

ggcggcgagc ccgacggcgg caagaucagc aacuuccugc uggagaagag cagaguggug      600

augagaaacc ccggcgagag aagcuuccac aucuucuacc agcugaucga gggcgccagc      660

gccgagcaga agcacagccu gggcaucacc agcauggacu acuacuacua ccugagccug      720

agcggcagcu acaaggugga cgacaucgac gacagaagag aguuccagga gacccugcac      780

gccaugaacg ugaucggcau cuucgccgag gagcagaccc uggugcugca gaucguggcc      840

ggcauccugc accugggcaa caucagcuuc aaggaggugg gcaacuacgc cgccguggag      900

agcgaggagu uccuggccuu ccccgccuac cugcugggca ucaaccagga cagacugaag      960

gagaagcuga ccagcagaca gauggacagc aaguggggcg gcaagagcga gagcauccac     1020

gugacccuga acguggagca ggccugcuac accagagacg cccuggccaa ggcccugcac     1080

gccagagugu ucgacuuccu gguggacagc aucaacaagg ccauggagaa ggaccacgag     1140

gaguacaaca ucggcgugcu ggacaucuac ggcuucgaga ucuuccagaa gaacggcuuc     1200

gagcaguucu gcaucaacuu cgugaacgag aagcugcagc agaucuucau cgagcugacc     1260

cugaaggccg agcaggagga guacgugcag gagggcauca gauggacccc caucgaguac     1320

uucaacaaca agaucgugug cgaccugauc gagaacaagg ugaacccccc cggcaucaug     1380

agcauccugg acgacgugug cgccaccaug cacgccgugg gcgagggcgc cgaccagacc     1440

cugcugcaga agcugcagau gcagaucggc agccacgagc acuucaacag cuggaaccag     1500

ggcuucauca uccaccacua cgccggcaag gugagcuacg acauggacgg cuucugcgag     1560

agaaacagag acgugcuguu cauggaccug aucgagcuga ugcagagcag cgagcugccc     1620

uucaucaaga gccuguuccc cgagaaccug caggccgaca agaagggcag acccaccacc     1680

gccggcagca agaucaagaa gcaggccaac gaccugguga gcacccugau gaagugcacc     1740

ccccacuaca ucagaugcau caagcccaac gagaccaaga agcccagaga cugggaggag     1800

agcagaguga agcaccaggu ggaguaccug ggccugaagg agaacaucag agugagaaga     1860

gccggcuacg ccuacagaag aaucuuccag aaguuccugc agagauacgc cauccugacc     1920

aaggccaccu ggcccagcug gcagggcgag gagaagcagg gcgugcugca ccugcugcag     1980

agcgugaaca uggacagcga ccaguuccag cugggcagaa gcaagguguu caucaaggcc     2040

cccgagagcc uguuccugcu ggaggagaug agagagagaa aguacgacgg cuacgccaga     2100

gugauccaga agagcuggag aaaguucgug gccagaaaga aguacgugca gaugagagag     2160

gaggccagcg accugcugcu gaacaagaag gagagaagaa gaaacagcau caacagaaac     2220

uucaucggcg acuacaucgg cauggaggag caccccgagc ugcagcaguu cgugggcaag     2280

agagagaaga ucgacuucgc cgacaccgug accaaguacg acagaagauu caagggcgug     2340

aagagagacc ugcugcugac ccccaagugc cuguaccuga ucggcagaga gaaggugaag     2400

cagggccccg acaagggccu ggugaaggag gugcugaaga gaaagaucga gaucgagaga     2460

auccugagcg ugagccugag caccaugcag gacgacaucu ucauccugca cgagcaggag     2520

uacgacagcc ugcuggagag cguguucaag accgaguucc ugagccugcu ggccaagaga     2580

uacgaggaga agacccagaa gcagcugccc cugaaguuca gcaacacccu ggagcugaag     2640

cugaagaagg agaacugggg ccccuggagc gccggcggca gcagacaggu gcaguuccac     2700

cagggcuucg gcgaccuggc cgugcugaag cccagcaaca aggugcugca ggugagcauc     2760

ggccccggcc ugcccaagaa cagcagaccc accagaagaa acaccaccca gaacaccggc     2820

uacagcagcg gcacccagaa cgccaacuac cccgugagag ccgccccccc cccccccggc     2880

uaccaccaga acggcgugau cagaaaccag uacgugcccu acccccacgc ccccggcagc     2940

cagagaagca accagaagag ccuguacacc agcauggcca gacccccccu gcccagacag     3000

cagagcacca gcagcgacag agugagccag acccccgaga gccuggacuu ccugaaggug     3060

cccgaccagg gcgccgccgg cgugagaaga cagaccacca gcagaccccc ccccgccggc     3120

ggcagaccca agccccagcc caagcccaag ccccaggugc cccagugcaa ggcccuguac     3180

gccuacgacg cccaggacac cgacgagcug agcuucaacg ccaacgacau caucgacauc     3240

aucaaggagg accccagcgg cugguggacc ggcagacuga gaggcaagca gggccuguuc     3300

cccaacaacu acgugaccaa gaucuga                                         3327


<210>  2826
<211>  3327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1E__Homo_sapiens__CCDS32254.1

<400>  2826
augggcagca agggggugua ccaguaucac uggcaauccc auaacgucaa acacucugga       60

guugacgaua uggugcugcu cagcaagauc accgaaaauu ccauugugga aaaccugaaa      120

aagagauaca uggacgauua uaucuucaca uacauuggcu cuguccuuau cagcgugaau      180

cccuuuaaac agaugccuua uuucggggag aaggaaauug agauguacca gggagccgcu      240

caguaugaaa acccgcccca uaucuacgcc cuggcggaca auauguaccg gaacaugauc      300

auugaucgcg agaaucaaug cguuaucauu uccggcgagu cuggggcugg aaagacggug      360

gccgccaaau auaucaugag cuacauuucc agagucagcg gcggcgggac caaggugcag      420

cacguuaaag acaucauucu ccagucuaac ccucugcuug aggcuuuugg aaaugccaag      480

acagugcgga acaauaacuc cagccgcuuc ggcaaauauu uugagaucca guucucuccc      540

gggggagaac cugauggcgg gaagaucucc aauuuucugc ucgaaaagag cagagucgug      600

augcggaacc ccggagagcg cucuuuccau aucuuuuacc aacugauuga aggcgcuucc      660

gccgagcaga aacacagccu gggcauuacc uccauggacu auuacuauua ccucucucug      720

agcggguccu acaaggugga ugacaucgau gacagacggg aguuccagga gacacuucac      780

gcgaugaaug ucauuggaau cuuugccgag gaacagaccc ugguucucca aaucguggcu      840

ggcauucugc aucuugggaa caucagcuuc aaagaggugg gaaacuaugc cgcugucgaa      900

ucugaggaau uucuggccuu cccugcguac cuccugggca uuaaucagga ucgccugaag      960

gagaaacuca cauccagaca gauggacagc aaguggggag ggaaaucuga aagcauccac     1020

gugacccuga acguugagca agccuguuau acgcgggacg cucuugccaa ggcucugcau     1080

gcccgcgugu ucgauuuucu cgucgacucc auuaauaagg ccauggagaa agaucacgaa     1140

gaguacaaca ucggcgugcu ggacaucuau ggcuucgaaa uuuuucagaa gaauggguuc     1200

gagcaguuuu gcaucaacuu cguuaaugaa aaacuucagc aaauuuuuau cgagcugacc     1260

cucaaggcug agcaggaaga guacgugcag gaaggaauua gauggacacc gaucgaguau     1320

uucaacaaua aaauugucug ugaucugauc gagaacaagg ugaauccccc uggcaucaug     1380

ucuauucugg acgaugucug cgcgaccaug cacgccgugg gggaaggagc ugaccagaca     1440

cuccugcaaa aacuucagau gcagaucggc agccaugagc acuuuaacuc cuggaaucag     1500

ggguucauua uccaucacua cgccggcaaa guuagcuacg auauggacgg auuuugugaa     1560

cggaaccgcg augugcuguu cauggaccuc auugagcuga ugcaaucuuc cgaacuuccc     1620

uuuaucaaga gccuguuccc ugagaaucuc caggccgaca aaaagggcag acccaccacg     1680

gcugggucua aaaucaagaa gcaggccaac gaucuggucu ccacacugau gaaaugcacc     1740

ccgcauuaua uucgguguau caagccuaac gagacaaaga agcccagaga cugggaagag     1800

agccgcguga aacaccaggu ugaauaccuc ggacugaagg agaauauucg ggugagacgc     1860

gcgggcuaug cuuaccggag aaucuuccaa aaguuucuuc agcgcuaugc cauucugacc     1920

aaagccaccu ggccuuccug gcagggggaa gagaagcaag gaguccucca ucugcugcag     1980

ucugugaaca uggauagcga ccaguuccag cuuggccggu ccaaaguguu uaucaaggcu     2040

cccgagucuc ucuuccugcu ggaagagaug agagaacgca aauacgaugg guaugcccgg     2100

guuauccaaa agagcuggag aaaauuuguc gcucgcaaga aguacgugca gaugcgggag     2160

gaagccuccg accuccugcu uaauaaaaag gagagacggc gcaacagcau uaauagaaac     2220

uucaucggcg auuacauugg aauggaggaa caccccgagc ugcagcaguu ugugggcaaa     2280

cgggaaaaga ucgacuucgc ggauacaguc acgaaauaug acagacgcuu uaagggggug     2340

aagcgggauc uccugcugac cccuaaaugc cuuuaccuca uuggaagaga gaagguuaaa     2400

caaggcccgg acaaggggcu ggugaaagag guccugaagc gcaagaucga aaucgagcgg     2460

auucucucug ugucccugag cacaaugcag gaugacaucu ucauucuuca cgaacaggag     2520

uaugacucuc ugcucgaauc cguuuuuaaa accgaguucc ugagccugcu ugccaagaga     2580

uacgaggaga aaacacagaa gcaacucccc cugaaauuuu cuaauacccu ggaacucaag     2640

cugaagaaag aaaacugggg accuuggagc gcuggcgggu cccgccaggu gcaguuccau     2700

caaggcuucg gagaucuugc cguccugaag cccagcaaua aagugcucca gguuucuauc     2760

ggcccugggc ugcccaagaa cuccagaccg acgcggcgca auacaaccca gaacaccgga     2820

uauagcuccg gcacacagaa ugcuaacuac ccugugagag ccgcgccccc ucccccuggg     2880

uaucaccaaa auggagucau ucggaaccag uacgugcccu acccgcacgc cccuggcucu     2940

cagcgcagca accagaaauc ccuguauacc ucuauggcua gaccuccccu uccccggcaa     3000

cagagcacau ccucugaccg cgugagccag acgccggagu cccucgauuu ucugaagguc     3060

cccgaccagg gggccgcugg cguuagacgg caaaccacaa gcagaccucc cccugccgga     3120

ggccgcccca aaccucagcc caagccgaag ccucaggugc cccaguguaa agcccuguac     3180

gcuuaugaug cgcaagacac cgaugaacuc ucuuucaaug ccaacgacau cauugauauc     3240

aucaaggagg acccuuccgg gugguggaca ggacggcuga gaggcaaaca ggggcuuuuu     3300

cccaauaacu acgugaccaa gauuuga                                         3327


<210>  2827
<211>  1098
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1F__Homo_sapiens__O00160

<400>  2827

Met Gly Ser Lys Glu Arg Phe His Trp Gln Ser His Asn Val Lys Gln 
1               5                   10                  15      


Ser Gly Val Asp Asp Met Val Leu Leu Pro Gln Ile Thr Glu Asp Ala 
            20                  25                  30          


Ile Ala Ala Asn Leu Arg Lys Arg Phe Met Asp Asp Tyr Ile Phe Thr 
        35                  40                  45              


Tyr Ile Gly Ser Val Leu Ile Ser Val Asn Pro Phe Lys Gln Met Pro 
    50                  55                  60                  


Tyr Phe Thr Asp Arg Glu Ile Asp Leu Tyr Gln Gly Ala Ala Gln Tyr 
65                  70                  75                  80  


Glu Asn Pro Pro His Ile Tyr Ala Leu Thr Asp Asn Met Tyr Arg Asn 
                85                  90                  95      


Met Leu Ile Asp Cys Glu Asn Gln Cys Val Ile Ile Ser Gly Glu Ser 
            100                 105                 110         


Gly Ala Gly Lys Thr Val Ala Ala Lys Tyr Ile Met Gly Tyr Ile Ser 
        115                 120                 125             


Lys Val Ser Gly Gly Gly Glu Lys Val Gln His Val Lys Asp Ile Ile 
    130                 135                 140                 


Leu Gln Ser Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val 
145                 150                 155                 160 


Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Tyr Phe Glu Ile Gln Phe 
                165                 170                 175     


Ser Arg Gly Gly Glu Pro Asp Gly Gly Lys Ile Ser Asn Phe Leu Leu 
            180                 185                 190         


Glu Lys Ser Arg Val Val Met Gln Asn Glu Asn Glu Arg Asn Phe His 
        195                 200                 205             


Ile Tyr Tyr Gln Leu Leu Glu Gly Ala Ser Gln Glu Gln Arg Gln Asn 
    210                 215                 220                 


Leu Gly Leu Met Thr Pro Asp Tyr Tyr Tyr Tyr Leu Asn Gln Ser Asp 
225                 230                 235                 240 


Thr Tyr Gln Val Asp Gly Thr Asp Asp Arg Ser Asp Phe Gly Glu Thr 
                245                 250                 255     


Leu Ser Ala Met Gln Val Ile Gly Ile Pro Pro Ser Ile Gln Gln Leu 
            260                 265                 270         


Val Leu Gln Leu Val Ala Gly Ile Leu His Leu Gly Asn Ile Ser Phe 
        275                 280                 285             


Cys Glu Asp Gly Asn Tyr Ala Arg Val Glu Ser Val Asp Leu Leu Ala 
    290                 295                 300                 


Phe Pro Ala Tyr Leu Leu Gly Ile Asp Ser Gly Arg Leu Gln Glu Lys 
305                 310                 315                 320 


Leu Thr Ser Arg Lys Met Asp Ser Arg Trp Gly Gly Arg Ser Glu Ser 
                325                 330                 335     


Ile Asn Val Thr Leu Asn Val Glu Gln Ala Ala Tyr Thr Arg Asp Ala 
            340                 345                 350         


Leu Ala Lys Gly Leu Tyr Ala Arg Leu Phe Asp Phe Leu Val Glu Ala 
        355                 360                 365             


Ile Asn Arg Ala Met Gln Lys Pro Gln Glu Glu Tyr Ser Ile Gly Val 
    370                 375                 380                 


Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn Gly Phe Glu Gln 
385                 390                 395                 400 


Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln Ile Phe Ile Glu 
                405                 410                 415     


Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln Glu Gly Ile Arg 
            420                 425                 430         


Trp Thr Pro Ile Gln Tyr Phe Asn Asn Lys Val Val Cys Asp Leu Ile 
        435                 440                 445             


Glu Asn Lys Leu Ser Pro Pro Gly Ile Met Ser Val Leu Asp Asp Val 
    450                 455                 460                 


Cys Ala Thr Met His Ala Thr Gly Gly Gly Ala Asp Gln Thr Leu Leu 
465                 470                 475                 480 


Gln Lys Leu Gln Ala Ala Val Gly Thr His Glu His Phe Asn Ser Trp 
                485                 490                 495     


Ser Ala Gly Phe Val Ile His His Tyr Ala Gly Lys Val Ser Tyr Asp 
            500                 505                 510         


Val Ser Gly Phe Cys Glu Arg Asn Arg Asp Val Leu Phe Ser Asp Leu 
        515                 520                 525             


Ile Glu Leu Met Gln Thr Ser Glu Gln Ala Phe Leu Arg Met Leu Phe 
    530                 535                 540                 


Pro Glu Lys Leu Asp Gly Asp Lys Lys Gly Arg Pro Ser Thr Ala Gly 
545                 550                 555                 560 


Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ala Thr Leu Met Arg 
                565                 570                 575     


Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Glu Thr Lys Arg 
            580                 585                 590         


Pro Arg Asp Trp Glu Glu Asn Arg Val Lys His Gln Val Glu Tyr Leu 
        595                 600                 605             


Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly Phe Ala Tyr Arg 
    610                 615                 620                 


Arg Gln Phe Ala Lys Phe Leu Gln Arg Tyr Ala Ile Leu Thr Pro Glu 
625                 630                 635                 640 


Thr Trp Pro Arg Trp Arg Gly Asp Glu Arg Gln Gly Val Gln His Leu 
                645                 650                 655     


Leu Arg Ala Val Asn Met Glu Pro Asp Gln Tyr Gln Met Gly Ser Thr 
            660                 665                 670         


Lys Val Phe Val Lys Asn Pro Glu Ser Leu Phe Leu Leu Glu Glu Val 
        675                 680                 685             


Arg Glu Arg Lys Phe Asp Gly Phe Ala Arg Thr Ile Gln Lys Ala Trp 
    690                 695                 700                 


Arg Arg His Val Ala Val Arg Lys Tyr Glu Glu Met Arg Glu Glu Ala 
705                 710                 715                 720 


Ser Asn Ile Leu Leu Asn Lys Lys Glu Arg Arg Arg Asn Ser Ile Asn 
                725                 730                 735     


Arg Asn Phe Val Gly Asp Tyr Leu Gly Leu Glu Glu Arg Pro Glu Leu 
            740                 745                 750         


Arg Gln Phe Leu Gly Lys Arg Glu Arg Val Asp Phe Ala Asp Ser Val 
        755                 760                 765             


Thr Lys Tyr Asp Arg Arg Phe Lys Pro Ile Lys Arg Asp Leu Ile Leu 
    770                 775                 780                 


Thr Pro Lys Cys Val Tyr Val Ile Gly Arg Glu Lys Val Lys Lys Gly 
785                 790                 795                 800 


Pro Glu Lys Gly Gln Val Cys Glu Val Leu Lys Lys Lys Val Asp Ile 
                805                 810                 815     


Gln Ala Leu Arg Gly Val Ser Leu Ser Thr Arg Gln Asp Asp Phe Phe 
            820                 825                 830         


Ile Leu Gln Glu Asp Ala Ala Asp Ser Phe Leu Glu Ser Val Phe Lys 
        835                 840                 845             


Thr Glu Phe Val Ser Leu Leu Cys Lys Arg Phe Glu Glu Ala Thr Arg 
    850                 855                 860                 


Arg Pro Leu Pro Leu Thr Phe Ser Asp Thr Leu Gln Phe Arg Val Lys 
865                 870                 875                 880 


Lys Glu Gly Trp Gly Gly Gly Gly Thr Arg Ser Val Thr Phe Ser Arg 
                885                 890                 895     


Gly Phe Gly Asp Leu Ala Val Leu Lys Val Gly Gly Arg Thr Leu Thr 
            900                 905                 910         


Val Ser Val Gly Asp Gly Leu Pro Lys Ser Ser Lys Pro Thr Arg Lys 
        915                 920                 925             


Gly Met Ala Lys Gly Lys Pro Arg Arg Ser Ser Gln Ala Pro Thr Arg 
    930                 935                 940                 


Ala Ala Pro Ala Pro Pro Arg Gly Met Asp Arg Asn Gly Val Pro Pro 
945                 950                 955                 960 


Ser Ala Arg Gly Gly Pro Leu Pro Leu Glu Ile Met Ser Gly Gly Gly 
                965                 970                 975     


Thr His Arg Pro Pro Arg Gly Pro Pro Ser Thr Ser Leu Gly Ala Ser 
            980                 985                 990         


Arg Arg Pro Arg Ala Arg Pro Pro Ser Glu His Asn Thr Glu Phe Leu 
        995                 1000                1005            


Asn Val Pro Asp Gln Gly Met Ala Gly Met Gln Arg Lys Arg Ser Val 
    1010                1015                1020                


Gly Gln Arg Pro Val Pro Gly Val Gly Arg Pro Lys Pro Gln Pro Arg 
1025                1030                1035                1040


Thr His Gly Pro Arg Cys Arg Ala Leu Tyr Gln Tyr Val Gly Gln Asp 
                1045                1050                1055    


Val Asp Glu Leu Ser Phe Asn Val Asn Glu Val Ile Glu Ile Leu Met 
            1060                1065                1070        


Glu Asp Pro Ser Gly Trp Trp Lys Gly Arg Leu His Gly Gln Glu Gly 
        1075                1080                1085            


Leu Phe Pro Gly Asn Tyr Val Glu Lys Ile 
    1090                1095            


<210>  2828
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1F__Homo_sapiens__AAH28071

<400>  2828
augggcagca aggagcgcuu ccacuggcag agccacaacg ugaagcagag cggcguggau       60

gacauggugc uucuucccca gaucaccgaa gacgccauug ccgccaaccu ccggaagcgc      120

uucauggacg acuacaucuu caccuacauc ggcucugugc ucaucucugu aaaccccuuc      180

aagcagaugc ccuacuucac cgaccgugag aucgaccucu aucagggcgc ggcccaguau      240

gagaaucccc cgcacaucua cgcccucacg gacaacaugu accggaacau gcuuaucgac      300

ugugagaacc agugugucau cauuagugga gagaguggag cugggaagac aguggcagcc      360

aaauauauca ugggcuacau cuccaaggug ucuggcggag gcgagaaggu ccagcacguc      420

aaagauauca uccugcaguc caacccgcug cucgaggccu ucggcaacgc caagacugug      480

cgcaacaaca auuccagccg cuuuggcaag uacuuugaga uccaguucag ccgagguggg      540

gagccagaug ggggcaagau cuccaacuuc uugcuggaga agucccgcgu ggucaugcaa      600

aaugaaaaug agaggaacuu ccacaucuac uaccagcugc uggaaggggc cucccaggag      660

caaaggcaga accugggccu caugacaccg gacuacuauu acuaccucaa ccaaucggac      720

accuaccagg uggacggcac ggacgacaga agcgacuuug gugagacucu gagugcuaug      780

cagguuauug ggaucccgcc cagcauccag cagcuggucc ugcagcucgu ggcggggauc      840

uugcaccugg ggaacaucag uuucugugaa gacgggaauu acgcccgagu ggagagugug      900

gaccuccugg ccuuucccgc cuaccugcug ggcauugaca gcgggcgacu gcaggagaag      960

cugaccagcc gcaagaugga cagccgcugg ggcgggcgca gcgaguccau caaugugacc     1020

cucaacgugg agcaggcagc cuacacccgu gaugcccugg ccaaggggcu cuaugcccgc     1080

cucuucgacu uccucgugga ggccaucaac cgugcuaugc agaaacccca ggaagaguac     1140

agcaucggug ugcuggacau uuacggcuuc gagaucuucc agaaaaaugg cuucgagcag     1200

uuuugcauca acuucgucaa ugagaagcug cagcaaaucu uuaucgaacu uacccugaag     1260

gccgagcagg aggaguaugu gcaggaaggc auccgcugga cuccaaucca guacuucaac     1320

aacaaggucg ucugugaccu caucgaaaac aagcugagcc ccccaggcau caugagcguc     1380

uuggacgacg ugugcgccac caugcacgcc acgggcgggg gagcagacca gacacugcug     1440

cagaagcugc aggcggcugu ggggacccac gagcauuuca acagcuggag cgccggcuuc     1500

gucauccacc acuacgcugg caaggucucc uacgacguca gcggcuucug cgagaggaac     1560

cgagacguuc ucuucuccga ccucauagag cugaugcaga ccagugagca ggccuuccuc     1620

cggaugcucu uccccgagaa gcuggaugga gacaagaagg ggcgccccag caccgccggc     1680

uccaagauca agaaacaagc caacgaccug guggccacac ugaugaggug cacaccccac     1740

uacauccgcu gcaucaaacc caacgagacc aagaggcccc gagacuggga ggagaacaga     1800

gucaagcacc agguggaaua ccugggccug aaggagaaca ucagggugcg cagagccggc     1860

uucgccuacc gccgccaguu cgccaaauuc cugcagaggu augccauucu gacccccgag     1920

acguggccgc gguggcgugg ggacgaacgc cagggcgucc agcaccugcu ucgggcgguc     1980

aacauggagc ccgaccagua ccagaugggg agcaccaagg ucuuugucaa gaacccagag     2040

ucgcuuuucc uccuggagga ggugcgagag cgaaaguucg auggcuuugc ccgaaccauc     2100

cagaaggccu ggcggcgcca cguggcuguc cggaaguacg aggagaugcg ggaggaagcu     2160

uccaacaucc ugcugaacaa gaaggagcgg aggcgcaaca gcaucaaucg gaacuucguc     2220

ggggacuacc uggggcugga ggagcggccc gagcugcguc aguuccuggg caagagggag     2280

cggguggacu ucgccgauuc ggucaccaag uacgaccgcc gcuucaagcc caucaagcgg     2340

gacuugaucc ugacgcccaa guguguguau gugauugggc gagagaaagu gaagaaggga     2400

ccugagaagg gccaggugug ugaagucuug aagaagaaag uggacaucca ggcucugcgg     2460

ggagucuccc ucagcacgcg acaggacgac uucuucaucc uccaagagga ugccgccgac     2520

agcuuccugg agagcgucuu caagaccgag uuugucagcc uucugugcaa gcgcuucgag     2580

gaggcgacgc ggaggccccu gccccucacc uucagcgaca cacuacaguu ucgggugaag     2640

aaggagggcu ggggcggugg cggcacccgc agcgucaccu ucucccgcgg cuucggcgac     2700

uuggcagugc ucaagguugg cggucggacc cucacgguca gcgugggcga ugggcugccc     2760

aagagcucca agccuacgcg gaagggaaug gccaagggaa aaccucggag gucgucccaa     2820

gccccuaccc gggcggcccc ugcgcccccc agaggcaugg aucgcaaugg ggugcccccc     2880

ucugccagag ggggcccccu gccccuggag aucaugucug gagggggcac ccacaggccu     2940

ccccggggcc cuccguccac aucccuggga gccagcagac gaccccgggc acguccgccc     3000

ucagagcaca acacagaauu ccucaacgug ccugaccagg gcauggccgg caugcagagg     3060

aagcgcagcg uggggcaacg gccagugccu ggugugggcc gacccaagcc ccagccucgg     3120

acacaugguc ccaggugccg ggcccuauac caguacgugg gccaagaugu ggacgagcug     3180

agcuucaacg ugaacgaggu cauugagauc cucauggaag aucccucggg cugguggaag     3240

ggccggcuuc acggccagga gggccuuuuc ccaggaaacu acguggagaa gaucuga        3297


<210>  2829
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1F__Homo_sapiens__AAH28071

<400>  2829
augggcagca aggagcgcuu ccacuggcag ucccacaacg ugaagcagag cggggucgac       60

gacauggugc ugcuccccca gaucaccgag gacgccaucg ccgcgaaccu gcggaagcgc      120

uucauggacg acuacaucuu caccuacauc ggcuccgugc ugaucagcgu caacccguuc      180

aagcagaugc ccuacuucac ggaccgggag aucgaccucu accagggggc cgcccaguac      240

gagaacccgc cccacaucua cgcccugacc gacaacaugu accgcaacau gcugaucgac      300

ugcgagaacc agugcgugau caucuccggc gagagcgggg ccggcaagac cguggcggcc      360

aaguacauca ugggcuacau cuccaagguc agcgggggcg gggagaaggu gcagcacgug      420

aaggacauca uccuccaguc caacccccug cuggaggccu ucggcaacgc caagaccguc      480

cggaacaaca acagcucccg cuucgggaag uacuucgaga uccaguucag ccggggcggc      540

gagcccgacg ggggcaagau cuccaacuuc cuccuggaga agucccgcgu ggugaugcag      600

aacgagaacg agcggaacuu ccacaucuac uaccagcugc ucgagggggc gucccaggag      660

cagcgccaga accugggccu gaugacgccc gacuacuacu acuaccucaa ccagagcgac      720

accuaccagg ucgacggcac cgacgaccgg uccgacuucg gggagacccu gagcgccaug      780

caggucaucg gcaucccgcc cuccauccag cagcuggugc uccagcuggu cgccgggauc      840

cugcaccucg gcaacaucag cuucugcgag gacgggaacu acgcccgcgu ggagagcgug      900

gaccugcugg ccuuccccgc guaccuccug ggcaucgacu ccggccggcu gcaggagaag      960

cucacgagcc gcaagaugga cucccggugg ggcgggcgca gcgaguccau caacgucacc     1020

cugaacgugg agcaggccgc cuacacccgg gacgcccugg ccaaggggcu cuacgcgcgc     1080

cuguucgacu uccuggugga ggccaucaac cgggccaugc agaagcccca ggaggaguac     1140

agcaucggcg ugcucgacau cuacggguuc gagaucuucc agaagaacgg cuucgagcag     1200

uucugcauca acuucgugaa cgagaagcug cagcagaucu ucaucgagcu gacccucaag     1260

gccgagcagg aggaguacgu gcaggagggc auccgcugga cgcccaucca guacuucaac     1320

aacaaggucg ugugcgaccu gaucgagaac aagcugagcc cgcccgggau caugagcguc     1380

cucgacgacg ugugcgccac caugcacgcg accggcgggg gcgccgacca gacccugcug     1440

cagaagcucc aggccgccgu ggggacgcac gagcacuuca acuccuggag cgccggcuuc     1500

gucauccacc acuacgcggg caaggugucc uacgacguga gcggguucug cgagcggaac     1560

cgcgacgucc uguucuccga ccugaucgag cucaugcaga ccagcgagca ggccuuccug     1620

cgcaugcugu uccccgagaa gcucgacggc gacaagaagg ggcggcccuc caccgccggc     1680

agcaagauca agaagcaggc caacgaccug guggcgaccc ugaugcgcug cacgccgcac     1740

uacauccggu gcaucaagcc caacgagacc aagcgccccc gggacuggga ggagaaccgc     1800

gugaagcacc aggucgagua ccugggccuc aaggagaaca uccgggugcg ccgggccggg     1860

uucgccuacc gccggcaguu cgccaaguuc cugcagcgcu acgccauccu gacccccgag     1920

accuggccgc gguggcgcgg cgacgagcgg cagggggugc agcaccuccu gcgcgcgguc     1980

aacauggagc ccgaccagua ccagaugggc uccacgaagg uguucgugaa gaaccccgag     2040

agccuguucc uccuggagga gguccgggag cgcaaguucg acggguucgc ccggaccauc     2100

cagaaggccu ggcgccgcca cguggccgug cggaaguacg aggagaugcg cgaggaggcc     2160

uccaacaucc ugcucaacaa gaaggagcgg cgccggaaca gcaucaaccg caacuucguc     2220

ggcgacuacc ugggccugga ggagcggccc gagcuccgcc aguuccuggg gaagcgggag     2280

cgcguggacu ucgcggacag cgugaccaag uacgaccggc gcuucaagcc gaucaagcgg     2340

gaccugaucc ucacccccaa gugcgucuac gugaucggcc gcgagaaggu gaagaagggg     2400

cccgagaagg gccaggucug cgaggugcug aagaagaagg uggacaucca ggcccugcgc     2460

ggggucuccc ucagcacgcg gcaggacgac uucuucaucc ugcaggagga cgccgccgac     2520

uccuuccugg agagcguguu caagaccgag uucguguccc uccugugcaa gcgguucgag     2580

gaggccaccc gccggccccu gccgcucacc uucagcgaca cgcugcaguu ccgcgucaag     2640

aaggagggcu ggggcggggg cgggacccgg uccgugaccu ucagccgcgg cuucggggac     2700

cuggcggugc ucaaggucgg cggccgcacc cugacggugu ccguggggga cggccugccc     2760

aagagcucca agcccacccg gaaggggaug gccaagggca agccgcgccg gagcucccag     2820

gcccccaccc gcgccgcgcc cgcgcccccg cgggggaugg accgcaacgg cgucccgccc     2880

agcgcccggg gcgggccccu cccccuggag aucauguccg gcgggggcac ccaccgcccg     2940

ccccggggcc cgcccagcac cucccugggg gccagccgcc ggccccgcgc ccggccgccc     3000

agcgagcaca acacggaguu ccucaacgug cccgaccagg gcauggccgg gaugcagcgc     3060

aagcgguccg ugggccagcg ccccgucccc ggggugggcc ggcccaagcc ccagccccgc     3120

acccacggcc cccggugccg cgcccuguac caguacgugg ggcaggacgu cgacgagcug     3180

agcuucaacg ugaacgaggu gaucgagauc cucauggagg accccuccgg cugguggaag     3240

gggcgccugc acggccagga ggggcuguuc ccgggcaacu acgucgagaa gaucuga        3297


<210>  2830
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1F__Homo_sapiens__AAH28071

<400>  2830
augggcucca aggagcgcuu ccacuggcag ucccacaacg ucaagcaguc cggcgucgac       60

gacauggucc uccuccccca gaucaccgag gacgccaucg ccgccaaccu ccgcaagcgc      120

uucauggacg acuacaucuu caccuacauc ggcuccgucc ucaucuccgu caaccccuuc      180

aagcagaugc ccuacuucac cgaccgcgag aucgaccucu accagggcgc cgcccaguac      240

gagaaccccc cccacaucua cgcccucacc gacaacaugu accgcaacau gcucaucgac      300

ugcgagaacc agugcgucau caucuccggc gaguccggcg ccggcaagac cgucgccgcc      360

aaguacauca ugggcuacau cuccaagguc uccggcggcg gcgagaaggu ccagcacguc      420

aaggacauca uccuccaguc caacccccuc cucgaggccu ucggcaacgc caagaccguc      480

cgcaacaaca acuccucccg cuucggcaag uacuucgaga uccaguucuc ccgcggcggc      540

gagcccgacg gcggcaagau cuccaacuuc cuccucgaga agucccgcgu cgucaugcag      600

aacgagaacg agcgcaacuu ccacaucuac uaccagcucc ucgagggcgc cucccaggag      660

cagcgccaga accucggccu caugaccccc gacuacuacu acuaccucaa ccaguccgac      720

accuaccagg ucgacggcac cgacgaccgc uccgacuucg gcgagacccu cuccgccaug      780

caggucaucg gcaucccccc cuccauccag cagcucgucc uccagcucgu cgccggcauc      840

cuccaccucg gcaacaucuc cuucugcgag gacggcaacu acgcccgcgu cgaguccguc      900

gaccuccucg ccuuccccgc cuaccuccuc ggcaucgacu ccggccgccu ccaggagaag      960

cucaccuccc gcaagaugga cucccgcugg ggcggccgcu ccgaguccau caacgucacc     1020

cucaacgucg agcaggccgc cuacacccgc gacgcccucg ccaagggccu cuacgcccgc     1080

cucuucgacu uccucgucga ggccaucaac cgcgccaugc agaagcccca ggaggaguac     1140

uccaucggcg uccucgacau cuacggcuuc gagaucuucc agaagaacgg cuucgagcag     1200

uucugcauca acuucgucaa cgagaagcuc cagcagaucu ucaucgagcu cacccucaag     1260

gccgagcagg aggaguacgu ccaggagggc auccgcugga cccccaucca guacuucaac     1320

aacaaggucg ucugcgaccu caucgagaac aagcucuccc cccccggcau cauguccguc     1380

cucgacgacg ucugcgccac caugcacgcc accggcggcg gcgccgacca gacccuccuc     1440

cagaagcucc aggccgccgu cggcacccac gagcacuuca acuccugguc cgccggcuuc     1500

gucauccacc acuacgccgg caaggucucc uacgacgucu ccggcuucug cgagcgcaac     1560

cgcgacgucc ucuucuccga ccucaucgag cucaugcaga ccuccgagca ggccuuccuc     1620

cgcaugcucu uccccgagaa gcucgacggc gacaagaagg gccgccccuc caccgccggc     1680

uccaagauca agaagcaggc caacgaccuc gucgccaccc ucaugcgcug caccccccac     1740

uacauccgcu gcaucaagcc caacgagacc aagcgccccc gcgacuggga ggagaaccgc     1800

gucaagcacc aggucgagua ccucggccuc aaggagaaca uccgcguccg ccgcgccggc     1860

uucgccuacc gccgccaguu cgccaaguuc cuccagcgcu acgccauccu cacccccgag     1920

accuggcccc gcuggcgcgg cgacgagcgc cagggcgucc agcaccuccu ccgcgccguc     1980

aacauggagc ccgaccagua ccagaugggc uccaccaagg ucuucgucaa gaaccccgag     2040

ucccucuucc uccucgagga gguccgcgag cgcaaguucg acggcuucgc ccgcaccauc     2100

cagaaggccu ggcgccgcca cgucgccguc cgcaaguacg aggagaugcg cgaggaggcc     2160

uccaacaucc uccucaacaa gaaggagcgc cgccgcaacu ccaucaaccg caacuucguc     2220

ggcgacuacc ucggccucga ggagcgcccc gagcuccgcc aguuccucgg caagcgcgag     2280

cgcgucgacu ucgccgacuc cgucaccaag uacgaccgcc gcuucaagcc caucaagcgc     2340

gaccucaucc ucacccccaa gugcgucuac gucaucggcc gcgagaaggu caagaagggc     2400

cccgagaagg gccaggucug cgagguccuc aagaagaagg ucgacaucca ggcccuccgc     2460

ggcgucuccc ucuccacccg ccaggacgac uucuucaucc uccaggagga cgccgccgac     2520

uccuuccucg aguccgucuu caagaccgag uucgucuccc uccucugcaa gcgcuucgag     2580

gaggccaccc gccgcccccu cccccucacc uucuccgaca cccuccaguu ccgcgucaag     2640

aaggagggcu ggggcggcgg cggcacccgc uccgucaccu ucucccgcgg cuucggcgac     2700

cucgccgucc ucaaggucgg cggccgcacc cucaccgucu ccgucggcga cggccucccc     2760

aaguccucca agcccacccg caagggcaug gccaagggca agccccgccg cuccucccag     2820

gcccccaccc gcgccgcccc cgcccccccc cgcggcaugg accgcaacgg cguccccccc     2880

uccgcccgcg gcggcccccu cccccucgag aucauguccg gcggcggcac ccaccgcccc     2940

ccccgcggcc cccccuccac cucccucggc gccucccgcc gcccccgcgc ccgccccccc     3000

uccgagcaca acaccgaguu ccucaacguc cccgaccagg gcauggccgg caugcagcgc     3060

aagcgcuccg ucggccagcg ccccgucccc ggcgucggcc gccccaagcc ccagccccgc     3120

acccacggcc cccgcugccg cgcccucuac caguacgucg gccaggacgu cgacgagcuc     3180

uccuucaacg ucaacgaggu caucgagauc cucauggagg accccuccgg cugguggaag     3240

ggccgccucc acggccagga gggccucuuc cccggcaacu acgucgagaa gaucuga        3297


<210>  2831
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1F__Homo_sapiens__AAH28071

<400>  2831
augggcagca aggagagauu ccacuggcag ucccauaacg ugaaacaauc uggggucgac       60

gauaugguuc ugcuccccca gaucaccgaa gacgccauug cugcaaaucu uaggaagcgg      120

uuuauggaug acuacauauu cacauauauc ggaucagugc ugauuagugu aaacccuuuu      180

aaacagaugc cauacuucac ugaucgcgag aucgacuugu aucagggugc cgcgcaauac      240

gaaaauccgc cccacauuua ugcuuuaacg gauaacaugu accgaaauau gcugaucgac      300

ugcgagaacc agugugugau aaucagcggc gaauccgggg ccggaaagac cgucgcagcc      360

aaauauauua ugggcuacau cucuaaggug ucgggugggg gagagaaggu ucagcaugug      420

aaagauauua uccuacaguc aaauccucuc cuggaggcuu uuggcaacgc aaagacaguc      480

cguaauaaca auagcaguag auucggcaaa uacuuugaaa uacaauucuc caggggagga      540

gagccagacg guggcaagau uucuaacuuu cuucuggaga aaagccgggu gguaaugcag      600

aaugaaaacg agcgcaauuu ccacaucuau uaccaguugc ucgaaggggc cucccaggag      660

caaagacaga accugggacu gaugacuccc gauuauuacu auuaccucaa ccagucagac      720

accuaucaag uugauggcac agacgacagg agugauuuug gugaaaccuu aagcgcuaug      780

caagugauug ggaucccucc aucuauccag cagcuggucc uucaguuggu ggccgggauu      840

cugcaucuag gcaauauauc cuucugcgag gacggcaacu acgcgcgggu ggaaucaguc      900

gaucuccugg cauuucccgc cuaccuucug gggaucgaca gcggacgcuu gcaggagaag      960

cucacuucac gaaagaugga uucuagaugg gguggcaggu ccgagagcau uaauguuaca     1020

cugaacgugg aacaggcugc cuauacccgg gacgcauuag cuaaagggcu guacgcccgu     1080

cucuucgauu uccuuguaga ggcgaucaau cgcgccaugc agaagccuca agaagaguau     1140

ucgauaggag ugcuggacau uuacggcuuu gaaaucuucc agaaaaacgg uuuugagcag     1200

uucuguauca auuuugucaa cgagaaguug cagcaaauuu ucaucgaacu aacgcugaaa     1260

gcagagcagg aagaguaugu gcaggaaggg auuagaugga cuccaauaca guacuuuaau     1320

aacaagguug ugugcgaucu caucgagaau aaacugucuc cgcccggcau uauguccguc     1380

cuugacgaug ugugugcuac caugcacgcc acaggaggcg gggcugacca aacucuguug     1440

cagaagcucc aggccgcagu aggaacccac gagcauuuca acucauggag ugccgguuuu     1500

guuauccacc auuaugcugg caaggugagc uacgacgucu ccggguucug cgaaaggaau     1560

cgggaugugc uguuuucuga cuuaaucgag cugaugcaaa caagcgaaca ggcguuccua     1620

cgaaugcucu uuccugagaa acuggaugga gacaagaaag gccgcccauc aaccgcaggu     1680

aguaagauua aaaagcaggc caacgaucuu gucgcuacgu ugaugagaug uacuccccac     1740

uacauaaggu gcaucaagcc uaaugagaca aaacggccac gcgacuggga agagaacaga     1800

gugaagcacc agguugaaua ucuggggcuc aaagagaaca uuagggugcg ucgggccggc     1860

uucgcauacc gaagacaauu cgccaaguuu cugcagaggu augcuauccu uacccccgaa     1920

acuuggccgc gcuggcgggg agaugagaga cagggcguac agcaucuguu gagggccguc     1980

aauauggagc cugaccaaua ccagaugggg uccacaaaag uguucguuaa gaaccccgaa     2040

agccucuuuc uguuagagga agugcgcgag cgaaaguucg auggauuugc acggaccauu     2100

cagaaagcgu ggcguagaca cgucgcugug aggaaguaug aagagaugcg cgaggaagcc     2160

ucuaauaucc ugcuaaacaa aaaggagcgg agaaggaaua guauaaaccg aaauuucgua     2220

ggugacuacc ucggccugga ggaacgccca gaacuucggc aguuuuuggg gaaaagagag     2280

aggguggauu ucgcagacag uguuacgaag uaugaucguc gcuuuaagcc uaucaaacgg     2340

gaccugauuc ucacccccaa gugugucuac gugaucggaa gagagaaagu gaagaaaggc     2400

ccagaaaagg gucaagucug cgagguucug aaaaagaagg uggacauuca ggccuuacga     2460

ggggugagcc uguccacaag gcaggaugac uucuuuaucc uucaagaaga ugcugccgac     2520

ucuuucuugg agucgguauu uaaaacugag uucgucagcc uccuguguaa gcgguucgaa     2580

gaggcaaccc gcagaccccu accucugaca uuuuccgaua cucuccaguu cagggugaaa     2640

aaggaaggcu ggggaggcgg gggaacccgg ucaguuacau uuagucgagg cuucggugac     2700

cuggcugugc uuaaagucgg gggaagaacc uugacugugu cuguuggcga uggucugcca     2760

aagagcucca agccgacgcg caaaggcaug gccaagggga aacccaggcg uucaagccag     2820

gcgccuacac gggccgcucc agcacccccu agaggaaugg acaggaacgg cgugccaccc     2880

ucugcccgcg ggggaccguu accucucgag auaauguccg gcggugggac ccaucgacca     2940

cccagaggac cucccaguac uagccugggc gcuucucgga ggccacgcgc ccguccuccc     3000

uccgaacaca auaccgaguu ucuuaacgua ccagaucagg guauggcagg caugcaaaga     3060

aagcggucag ucgggcagag gccggugccu ggagugggcc gccccaaacc acagccccga     3120

acacaugggc cuagaugccg ggcgcuguac caguaugucg gacaagacgu ugaugaguug     3180

aguuucaaug ugaacgaagu aauugagauc cucauggaag acccaagcgg cugguggaag     3240

gguaggcugc acgggcagga gggacuauuu cccggcaauu acguggaaaa gauuuga        3297


<210>  2832
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1F__Homo_sapiens__AAH28071

<400>  2832
augggcagca aggagagauu ccacuggcag agccacaacg ugaagcagag cggcguggac       60

gacauggugc ugcugcccca gaucaccgag gacgccaucg ccgccaaccu gagaaagaga      120

uucauggacg acuacaucuu caccuacauc ggcagcgugc ugaucagcgu gaaccccuuc      180

aagcagaugc ccuacuucac cgacagagag aucgaccugu accagggcgc cgcccaguac      240

gagaaccccc cccacaucua cgcccugacc gacaacaugu acagaaacau gcugaucgac      300

ugcgagaacc agugcgugau caucagcggc gagagcggcg ccggcaagac cguggccgcc      360

aaguacauca ugggcuacau cagcaaggug agcggcggcg gcgagaaggu gcagcacgug      420

aaggacauca uccugcagag caacccccug cuggaggccu ucggcaacgc caagaccgug      480

agaaacaaca acagcagcag auucggcaag uacuucgaga uccaguucag cagaggcggc      540

gagcccgacg gcggcaagau cagcaacuuc cugcuggaga agagcagagu ggugaugcag      600

aacgagaacg agagaaacuu ccacaucuac uaccagcugc uggagggcgc cagccaggag      660

cagagacaga accugggccu gaugaccccc gacuacuacu acuaccugaa ccagagcgac      720

accuaccagg uggacggcac cgacgacaga agcgacuucg gcgagacccu gagcgccaug      780

caggugaucg gcaucccccc cagcauccag cagcuggugc ugcagcuggu ggccggcauc      840

cugcaccugg gcaacaucag cuucugcgag gacggcaacu acgccagagu ggagagcgug      900

gaccugcugg ccuuccccgc cuaccugcug ggcaucgaca gcggcagacu gcaggagaag      960

cugaccagca gaaagaugga cagcagaugg ggcggcagaa gcgagagcau caacgugacc     1020

cugaacgugg agcaggccgc cuacaccaga gacgcccugg ccaagggccu guacgccaga     1080

cuguucgacu uccuggugga ggccaucaac agagccaugc agaagcccca ggaggaguac     1140

agcaucggcg ugcuggacau cuacggcuuc gagaucuucc agaagaacgg cuucgagcag     1200

uucugcauca acuucgugaa cgagaagcug cagcagaucu ucaucgagcu gacccugaag     1260

gccgagcagg aggaguacgu gcaggagggc aucagaugga cccccaucca guacuucaac     1320

aacaaggugg ugugcgaccu gaucgagaac aagcugagcc cccccggcau caugagcgug     1380

cuggacgacg ugugcgccac caugcacgcc accggcggcg gcgccgacca gacccugcug     1440

cagaagcugc aggccgccgu gggcacccac gagcacuuca acagcuggag cgccggcuuc     1500

gugauccacc acuacgccgg caaggugagc uacgacguga gcggcuucug cgagagaaac     1560

agagacgugc uguucagcga ccugaucgag cugaugcaga ccagcgagca ggccuuccug     1620

agaaugcugu uccccgagaa gcuggacggc gacaagaagg gcagacccag caccgccggc     1680

agcaagauca agaagcaggc caacgaccug guggccaccc ugaugagaug caccccccac     1740

uacaucagau gcaucaagcc caacgagacc aagagaccca gagacuggga ggagaacaga     1800

gugaagcacc agguggagua ccugggccug aaggagaaca ucagagugag aagagccggc     1860

uucgccuaca gaagacaguu cgccaaguuc cugcagagau acgccauccu gacccccgag     1920

accuggccca gauggagagg cgacgagaga cagggcgugc agcaccugcu gagagccgug     1980

aacauggagc ccgaccagua ccagaugggc agcaccaagg uguucgugaa gaaccccgag     2040

agccuguucc ugcuggagga ggugagagag agaaaguucg acggcuucgc cagaaccauc     2100

cagaaggccu ggagaagaca cguggccgug agaaaguacg aggagaugag agaggaggcc     2160

agcaacaucc ugcugaacaa gaaggagaga agaagaaaca gcaucaacag aaacuucgug     2220

ggcgacuacc ugggccugga ggagagaccc gagcugagac aguuccuggg caagagagag     2280

agaguggacu ucgccgacag cgugaccaag uacgacagaa gauucaagcc caucaagaga     2340

gaccugaucc ugacccccaa gugcguguac gugaucggca gagagaaggu gaagaagggc     2400

cccgagaagg gccaggugug cgaggugcug aagaagaagg uggacaucca ggcccugaga     2460

ggcgugagcc ugagcaccag acaggacgac uucuucaucc ugcaggagga cgccgccgac     2520

agcuuccugg agagcguguu caagaccgag uucgugagcc ugcugugcaa gagauucgag     2580

gaggccacca gaagaccccu gccccugacc uucagcgaca cccugcaguu cagagugaag     2640

aaggagggcu ggggcggcgg cggcaccaga agcgugaccu ucagcagagg cuucggcgac     2700

cuggccgugc ugaagguggg cggcagaacc cugaccguga gcgugggcga cggccugccc     2760

aagagcagca agcccaccag aaagggcaug gccaagggca agcccagaag aagcagccag     2820

gcccccacca gagccgcccc cgcccccccc agaggcaugg acagaaacgg cgugcccccc     2880

agcgccagag gcggcccccu gccccuggag aucaugagcg gcggcggcac ccacagaccc     2940

cccagaggcc cccccagcac cagccugggc gccagcagaa gacccagagc cagacccccc     3000

agcgagcaca acaccgaguu ccugaacgug cccgaccagg gcauggccgg caugcagaga     3060

aagagaagcg ugggccagag acccgugccc ggcgugggca gacccaagcc ccagcccaga     3120

acccacggcc ccagaugcag agcccuguac caguacgugg gccaggacgu ggacgagcug     3180

agcuucaacg ugaacgaggu gaucgagauc cugauggagg accccagcgg cugguggaag     3240

ggcagacugc acggccagga gggccuguuc cccggcaacu acguggagaa gaucuga        3297


<210>  2833
<211>  3297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1F__Homo_sapiens__AAH28071

<400>  2833
augggcagca aggagagauu ccacuggcag ucccauaacg ugaaacaauc uggggucgac       60

gauaugguuc ugcuccccca gaucaccgaa gacgccauug cugccaaucu gcggaagcgc      120

uuuauggaug acuacaucuu cacauauauu ggaagcgugc uuaucuccgu gaacccuuuu      180

aaacagaugc cguacuucac ggauagagag auugaccugu aucagggcgc ggcucaauac      240

gaaaaucccc cucacaucua ugcccucacc gauaacaugu accggaauau gcugaucgac      300

ugcgagaacc agugugucau uaucucuggg gaaagcggag ccggcaagac aguggcugcc      360

aaauauauua ugggguacau cuccaagguu ucuggaggcg gcgagaaggu gcagcauguc      420

aaagauauua uccuucagag caauccccug cucgaggcuu uugggaacgc caagaccgug      480

cgcaauaaca auuccagcag auucggaaaa uacuuugaaa uucaauucuc ucggggcggg      540

gagccugacg gaggcaagau cuccaacuuu cugcuggaaa aaucccgcgu ugugaugcag      600

aaugagaacg agagaaauuu ccacaucuau uaccagcucc uggaaggggc gucucaggag      660

caacggcaga accuuggacu gaugacaccc gauuauuacu auuaccucaa ccaguccgac      720

accuaucaag ucgauggcac agacgaccgc agcgauuuug gcgaaacccu gucugccaug      780

caagugauug ggaucccucc guccauucag cagcuugugc ugcagcucgu cgcuggaauc      840

cugcaucugg gcaauauuag cuucugcgag gacgggaacu acgccagagu ugaauccgug      900

gaucuccugg cuuuucccgc cuaccuucug ggaaucgacu cuggccggcu ccaggagaag      960

cugacgagcc gcaagaugga uuccagaugg ggagggcgga gcgagucuau caaugugacc     1020

cuuaacgucg aacaggcggc cuauacacgc gacgcucugg ccaaaggccu cuacgcuaga     1080

cuguucgauu uccuggugga ggccauuaau cgggccaugc agaagccuca agaagaguau     1140

uccaucggcg uucucgacau uuacggguuu gaaaucuucc agaaaaacgg auuugagcag     1200

uucuguauua auuuugugaa cgagaagcug cagcaaaucu ucaucgaacu uacccugaaa     1260

gcugagcagg aagaguaugu ccaggaaggc auuagaugga cacccaucca guacuuuaau     1320

aacaaggugg uuugcgaucu cauugagaau aaacugagcc cucccgggau caugucugug     1380

cuugacgaug ucugugcgac caugcacgcc acgggaggcg gggcugacca aacacugcuc     1440

cagaagcugc aggccgccgu gggcacccac gagcauuuca acagcugguc cgcuggauuu     1500

gucauucacc auuaugccgg caaggugucu uacgacguua gcggguucug cgaacgcaau     1560

cgggaugugc uguuuuccga ccucaucgag cugaugcaaa caagcgaaca ggcguuccuu     1620

agaaugcugu uuccggagaa acucgaugga gacaagaaag gccgcccuuc uaccgcuggg     1680

uccaagauua aaaagcaggc caacgaucug gucgccaccc ugaugcggug uacaccccac     1740

uacaucagau gcaucaagcc uaaugagacg aaacgccccc gggacuggga agagaacaga     1800

gugaagcacc agguugaaua ucuuggacuc aaagagaaca uucgcgugcg gagagcuggc     1860

uucgccuacc gccggcaauu cgcuaaguuu cugcagagau augccauccu gacccccgaa     1920

acauggccuc gguggcgcgg ggaugagaga cagggcgucc agcaucuccu gcgggcggug     1980

aauauggagc cggaccaaua ccagauggga agcaccaaag uguucguuaa gaaccccgaa     2040

ucucuuuuuc ugcucgagga agucagagag cgcaaguucg auggcuuugc ccggacaauu     2100

cagaaggcuu ggagacgcca cguggccgug agaaaauaug aagagaugcg ggaggaagcu     2160

agcaauaucc ugcugaacaa aaaggagcgc agacggaaua gcauuaaccg caauuucguc     2220

ggggacuacc uuggacucga agagagaccu gaacugcggc aguuucuggg caaacgcgag     2280

agaguggauu ucgccgacuc cguuaccaag uaugaucggc gcuuuaagcc caucaaaaga     2340

gaccucaucc ugacgccuaa guguguguac gucauugggc gggagaaagu gaagaaagga     2400

cccgaaaagg gccaaguuug cgaggugcuu aaaaagaagg ucgacaucca ggcgcugaga     2460

ggggugucuc ucagcacacg ccaggaugac uucuuuauuc ugcaagaaga ugccgcugac     2520

uccuuccugg agucuguuuu uaaaaccgag uucgugagcc uucucuguaa gcgguucgaa     2580

gaggccacca gacgcccgcu gccucugaca uuuuccgaua cccuccaguu ccgggucaaa     2640

aaggaaggcu ggggaggcgg gggaacaaga agcgugacgu uuucucgcgg cuucggggac     2700

cuggcugugc uuaaagucgg aggccggacc cugacaguuu ccguggggga uggccucccc     2760

aagagcucua agccuaccag aaaaggaaug gccaagggca aaccccgccg guccagccag     2820

gccccuacaa gagcugcgcc cgccccgccu cgggggaugg accgcaacgg agugccuccc     2880

ucugcuagag gcgggccccu gccgcuggag aucaugagcg gaggcggcac ccaucggccc     2940

ccucgcgggc ccccuuccac gagccuugga gccucuagac ggcccagagc ccgcccuccc     3000

uccgaacaca auaccgaguu ucucaacguc ccggaucagg gcauggcugg gaugcaacgg     3060

aagagaagcg ugggacagcg cccuguuccc ggcguggggc ggccuaaacc ccagccgaga     3120

acacauggac cucgcugccg ggcccuguac caguaugucg gccaagacgu ggaugagcug     3180

uccuucaaug uuaacgaagu gauugagauc cucauggaag accccucugg cugguggaag     3240

gggagacugc acggacagga gggccuuuuu ccugggaauu acgucgaaaa gaucuga        3297


<210>  2834
<211>  1018
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1G__Homo_sapiens__B0I1T2

<400>  2834

Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val Leu 
1               5                   10                  15      


Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu Arg 
            20                  25                  30          


Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val Ser 
        35                  40                  45              


Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile Ala 
    50                  55                  60                  


Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr Ala 
65                  70                  75                  80  


Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp Thr 
                85                  90                  95      


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110         


Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg 
        115                 120                 125             


Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val 
    130                 135                 140                 


Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser 
145                 150                 155                 160 


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175     


Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu 
            180                 185                 190         


Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu 
        195                 200                 205             


Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn 
    210                 215                 220                 


Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr 
225                 230                 235                 240 


Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr 
                245                 250                 255     


Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val 
            260                 265                 270         


His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val 
        275                 280                 285             


Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu 
    290                 295                 300                 


Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp 
305                 310                 315                 320 


Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg 
                325                 330                 335     


Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg 
            340                 345                 350         


Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val 
        355                 360                 365             


Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg 
    370                 375                 380                 


Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu 
385                 390                 395                 400 


Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn 
                405                 410                 415     


Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln 
            420                 425                 430         


Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe 
        435                 440                 445             


Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile 
    450                 455                 460                 


Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp 
465                 470                 475                 480 


Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His Leu His 
                485                 490                 495     


Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly 
            500                 505                 510         


Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr Ser Val 
        515                 520                 525             


Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp Phe Lys 
    530                 535                 540                 


Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met Trp Pro 
545                 550                 555                 560 


Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu Thr Ala 
                565                 570                 575     


Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn Leu Ala 
            580                 585                 590         


Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu Asp Lys 
        595                 600                 605             


Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val Ala Tyr 
    610                 615                 620                 


Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe Ala Ser 
625                 630                 635                 640 


Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr Cys Glu 
                645                 650                 655     


Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala Val Ser 
            660                 665                 670         


Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe Gly His 
        675                 680                 685             


Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu Glu Gln 
    690                 695                 700                 


Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln Lys Ala 
705                 710                 715                 720 


Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg Ala Ile 
                725                 730                 735     


Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala His Leu 
            740                 745                 750         


Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro Leu Tyr 
        755                 760                 765             


Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln Pro Phe 
    770                 775                 780                 


Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg Gln Leu 
785                 790                 795                 800 


Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala Lys Val 
                805                 810                 815     


Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly Cys Arg 
            820                 825                 830         


Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn Pro Thr 
        835                 840                 845             


Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp Lys Asp 
    850                 855                 860                 


Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val Asn Arg 
865                 870                 875                 880 


Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln His Leu 
                885                 890                 895     


Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala Val Pro 
            900                 905                 910         


Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp Gln Leu 
        915                 920                 925             


Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys Leu His 
    930                 935                 940                 


Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val Gly Val 
945                 950                 955                 960 


Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val Arg Val 
                965                 970                 975     


Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu Ile Ser 
            980                 985                 990         


Val Glu Pro Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys Ala Arg 
        995                 1000                1005            


Gly Ser Phe Thr Leu Leu Trp Pro Ser Arg 
    1010                1015            


<210>  2835
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1G__Homo_sapiens__CCDS34629.1

<400>  2835
auggaggacg aggaaggccc ugaguauggc aaaccugacu uugugcuuuu ggaccaagug       60

accauggagg acuucaugag gaaccugcag cucagguucg agaagggccg caucuacacc      120

uacaucggug aggugcuggu guccgugaac cccuaccagg agcugccccu guaugggccu      180

gaggccaucg ccagguacca gggccgugag cucuaugagc ggccacccca ucucuaugcu      240

guggccaacg ccgccuacaa ggcaaugaag caccggucca gggacaccug caucgucauc      300

ucaggggaga guggggcagg gaagacagaa gccaguaagc acaucaugca guacaucgcu      360

gcugucacca auccaagcca gagggcugag guggagaggg ucaaggacgu gcugcucaag      420

uccaccugug ugcuggaggc cuuuggcaau gcccgcacca accgcaauca caacuccagc      480

cgcuuuggca aguacaugga caucaacuuu gacuucaagg gggacccgau cggaggacac      540

auccacagcu accuacugga gaagucucgg guccucaagc agcacguggg ugaaagaaac      600

uuccacgccu ucuaccaauu gcugagaggc agugaggaca agcagcugca ugaacugcac      660

uuggagagaa acccugcugu auacaauuuc acacaccagg gagcaggacu caacaugacu      720

gugcacagug ccuuggacag ugaugagcag agccaccagg cagugaccga ggccaugagg      780

gucaucggcu ucaguccuga agagguggag ucugugcauc gcauccuggc ugccauauug      840

caccugggaa acaucgaguu uguggagacg gaggagggug ggcugcagaa ggagggccug      900

gcaguggccg aggaggcacu gguggaccau guggcugagc ugacggccac accccgggac      960

cucgugcucc gcucccugcu ggcucgcaca guugccucgg gaggcaggga acucauagag     1020

aagggccaca cugcagcuga ggccagcuau gcccgggaug ccugugccaa ggcaguguac     1080

cagcggcugu uugagugggu ggugaacagg aucaacagug ucauggaacc ccggggccgg     1140

gauccucggc gugauggcaa ggacacaguc auuggcgugc uggacaucua uggcuucgag     1200

guguuucccg ucaacaguuu cgagcaguuc ugcaucaacu acugcaacga gaagcugcag     1260

cagcuauuca uccagcucau ccugaagcag gaacaggaag aguacgagcg cgagggcauc     1320

accuggcaga gcguugagua uuucaacaac gccaccauug uggaucuggu ggagcggccc     1380

caccguggca uccuggccgu gcuggacgag gccugcagcu cugcuggcac caucacugac     1440

cgaaucuucc ugcagacccu ggacaugcac caccgccauc accuacacua caccagccgc     1500

cagcucugcc ccacagacaa gaccauggag uuuggccgag acuuccggau caagcacuau     1560

gcaggggacg ucacguacuc cguggaaggc uucaucgaca agaacagaga uuuccucuuc     1620

caggacuuca agcggcugcu guacaacagc acggacccca cucuacgggc cauguggccg     1680

gacgggcagc aggacaucac agaggugacc aagcgccccc ugacggcugg cacacucuuc     1740

aagaacucca ugguggcccu gguggagaac cuugccucca aggagcccuu cuacguccgc     1800

ugcaucaagc ccaaugagga caagguagcu gggaagcugg augagaacca cugucgccac     1860

caggucgcau accuggggcu gcuggagaau gugagggucc gcagggcugg cuucgcuucc     1920

cgccagcccu acucucgauu ccugcucagg uacaagauga ccugugaaua cacauggccc     1980

aaccaccugc ugggcuccga caaggcagcc gugagcgcuc uccuggagca gcacgggcug     2040

cagggggacg uggccuuugg ccacagcaag cuguucaucc gcucaccccg gacacugguc     2100

acacuggagc agagccgagc ccgccucauc cccaucauug ugcugcuauu gcagaaggca     2160

uggcggggca ccuuggcgag guggcgcugc cggaggcuga gggcuaucua caccaucaug     2220

cgcugguucc ggagacacaa ggugcgggcu caccuggcug agcugcagcg gcgauuccag     2280

gcugcaaggc agccgccacu cuacgggcgu gaccuugugu ggccgcugcc cccugcugug     2340

cugcagcccu uccaggacac cugccacgca cucuucugca gguggcgggc ccggcagcug     2400

gugaagaaca uccccccuuc agacaugccc cagaucaagg ccaagguggc cgccaugggg     2460

gcccugcaag ggcuucguca ggacuggggc ugccgacggg ccugggcccg agacuaccug     2520

uccucugcca cugacaaucc cacagcauca agccuguuug cucagcgacu aaagacacuu     2580

caggacaaag auggcuucgg ggcugugcuc uuuucaagcc auguccgcaa ggugaaccgc     2640

uuccacaaga uccggaaccg ggcccuccug cucacagacc agcaccucua caagcuggac     2700

ccugaccggc aguaccgggu gaugcgggcc gugccccuug aggcggugac ggggcugagc     2760

gugaccagcg gaggagacca gcugguggug cugcacgccc gcggccagga cgaccucgug     2820

gugugccugc accgcucccg gccgccauug gacaaccgcg uuggggagcu ggugggcgug     2880

cuggccgcac acugccaggg ggagggccgc acccuggagg uucgcgucuc cgacugcauc     2940

ccacuaagcc aucgcggggu ccggcgccuc aucuccgugg agcccaggcc ggagcagcca     3000

gagcccgauu uccgcugcgc ucgcggcucc uucacccugc ucuggcccag ccgcuga        3057


<210>  2836
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1G__Homo_sapiens__CCDS34629.1

<400>  2836
auggaggacg aggagggccc cgaguacggg aagccggacu ucgugcugcu cgaccagguc       60

accauggagg acuucaugcg caaccugcag cugcgguucg agaagggccg caucuacacc      120

uacaucgggg aggugcucgu gagcgucaac cccuaccagg agcugccccu guacggcccc      180

gaggccaucg cccgguacca ggggcgcgag cucuacgagc ggccgcccca ccuguacgcg      240

guggccaacg ccgccuacaa ggccaugaag caccgcuccc gggacacgug caucgugauc      300

agcggcgagu ccggcgcggg gaagaccgag gccagcaagc acaucaugca guacaucgcc      360

gccgucacca accccuccca gcgcgcggag guggagcggg ugaaggacgu ccugcucaag      420

agcaccugcg ugcuggaggc cuucggcaac gcccgcacga accggaacca caacuccagc      480

cgcuucggga aguacaugga caucaacuuc gacuucaagg gcgaccccau cgggggccac      540

auccacuccu accugcucga gaagagccgg gugcugaagc agcacgucgg cgagcgcaac      600

uuccacgccu ucuaccagcu gcuccggggg uccgaggaca agcagcugca cgagcugcac      660

cucgagcgca acccggccgu guacaacuuc acccaccagg gcgcggggcu gaacaugacc      720

gugcacagcg cccuggacuc cgacgagcag agccaccagg ccgucaccga ggccaugcgg      780

gugaucggcu ucucccccga ggagguggag agcguccacc gcauccucgc cgcgauccug      840

caccugggca acaucgaguu cguggagacg gaggaggggg gccuccagaa ggaggggcug      900

gccguggccg aggaggcccu ggucgaccac guggccgagc ucaccgcgac cccccgggac      960

cuggugcugc gcucccuccu ggcccggacc gucgccagcg gcgggcgcga gcugaucgag     1020

aagggccaca cggccgccga ggcguccuac gcccgcgacg ccugcgccaa ggcgguguac     1080

cagcggcucu ucgagugggu cgugaaccgc aucaacagcg ugauggagcc ccggggccgc     1140

gacccgcggc gcgacgggaa ggacaccguc aucggcgugc uggacaucua cggguucgag     1200

guguuccccg ucaacagcuu cgagcaguuc ugcaucaacu acugcaacga gaagcugcag     1260

cagcucuuca uccagcugau ccugaagcag gagcaggagg aguacgagcg ggagggcauc     1320

accuggcagu ccguggagua cuucaacaac gccaccaucg uggaccucgu cgagcgcccc     1380

caccggggga uccuggccgu gcuggacgag gccugcagcu ccgccggcac gaucaccgac     1440

cgcaucuucc uccagacccu ggacaugcac caccggcacc accugcacua caccagccgc     1500

cagcucugcc ccacggacaa gaccauggag uucggccggg acuuccgcau caagcacuac     1560

gcgggggacg ugaccuacuc cgucgagggc uucaucgaca agaaccggga cuuccuguuc     1620

caggacuuca agcgccugcu cuacaacagc accgacccga cgcugcgggc cauguggccc     1680

gacgggcagc aggacaucac cgaggugacc aagcgccccc ugaccgccgg cacgcuguuc     1740

aagaacucca ugguggcccu cgucgagaac cuggccagca aggagcccuu cuacgugcgg     1800

ugcaucaagc cgaacgagga caagguggcg gggaagcugg acgagaacca cugccgccac     1860

caggucgccu accucggccu gcuggagaac gugcgcgugc ggcgcgccgg cuucgccucc     1920

cggcagcccu acagccgcuu ccuccugcgg uacaagauga ccugcgagua caccuggccc     1980

aaccaccugc ucggguccga caaggccgcg gucagcgccc ugcuggagca gcacggccuc     2040

cagggggacg uggccuucgg ccacuccaag cuguucaucc gcagcccccg gacccuggug     2100

acgcucgagc agucccgcgc ccggcugauc ccgaucaucg uccugcuccu gcagaaggcg     2160

uggcgcggca cccuggcccg guggcgcugc cggcgccucc gggccaucua caccaucaug     2220

cgcugguucc ggcgccacaa ggugcgggcc caccuggccg agcugcagcg ccgguuccag     2280

gcggcccgcc agcccccccu cuacgggcgc gaccuggugu ggccccugcc gcccgccguc     2340

cuccagcccu uccaggacac cugccacgcc cuguucugcc gguggcgcgc ccggcagcug     2400

gugaagaaca ucccgcccag cgacaugccc cagaucaagg cgaagguggc cgccaugggc     2460

gcccuccagg ggcugcgcca ggacuggggc ugccggcgcg ccugggcgcg ggacuaccug     2520

uccagcgcca cggacaaccc caccgccucc agccucuucg cccagcgccu gaagacccug     2580

caggacaagg acggguucgg cgcgguccuc uucagcuccc acgugcggaa ggugaaccgc     2640

uuccacaaga uccggaaccg cgcccugcug cucaccgacc agcaccugua caagcuggac     2700

ccggaccggc aguaccgcgu caugcgggcc gugccccucg aggccgugac cggccugagc     2760

gucacguccg ggggcgacca gcugguggug cuccacgccc gcgggcagga cgaccugguc     2820

gugugccugc accggagccg ccccccccuc gacaaccggg ugggcgagcu ggucggggug     2880

cuggcggccc acugccaggg cgagggccgc acccucgagg ugcgcgucuc cgacugcauc     2940

ccgcugagcc accggggggu gcgccggcug aucuccgugg agccccgccc cgagcagccc     3000

gagccggacu uccggugcgc ccgcggcagc uucacccucc uguggcccuc ccgguga        3057


<210>  2837
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1G__Homo_sapiens__CCDS34629.1

<400>  2837
auggaggacg aggagggccc cgaguacggc aagcccgacu ucguccuccu cgaccagguc       60

accauggagg acuucaugcg caaccuccag cuccgcuucg agaagggccg caucuacacc      120

uacaucggcg agguccucgu cuccgucaac cccuaccagg agcucccccu cuacggcccc      180

gaggccaucg cccgcuacca gggccgcgag cucuacgagc gcccccccca ccucuacgcc      240

gucgccaacg ccgccuacaa ggccaugaag caccgcuccc gcgacaccug caucgucauc      300

uccggcgagu ccggcgccgg caagaccgag gccuccaagc acaucaugca guacaucgcc      360

gccgucacca accccuccca gcgcgccgag gucgagcgcg ucaaggacgu ccuccucaag      420

uccaccugcg uccucgaggc cuucggcaac gcccgcacca accgcaacca caacuccucc      480

cgcuucggca aguacaugga caucaacuuc gacuucaagg gcgaccccau cggcggccac      540

auccacuccu accuccucga gaagucccgc guccucaagc agcacgucgg cgagcgcaac      600

uuccacgccu ucuaccagcu ccuccgcggc uccgaggaca agcagcucca cgagcuccac      660

cucgagcgca accccgccgu cuacaacuuc acccaccagg gcgccggccu caacaugacc      720

guccacuccg cccucgacuc cgacgagcag ucccaccagg ccgucaccga ggccaugcgc      780

gucaucggcu ucucccccga ggaggucgag uccguccacc gcauccucgc cgccauccuc      840

caccucggca acaucgaguu cgucgagacc gaggagggcg gccuccagaa ggagggccuc      900

gccgucgccg aggaggcccu cgucgaccac gucgccgagc ucaccgccac cccccgcgac      960

cucguccucc gcucccuccu cgcccgcacc gucgccuccg gcggccgcga gcucaucgag     1020

aagggccaca ccgccgccga ggccuccuac gcccgcgacg ccugcgccaa ggccgucuac     1080

cagcgccucu ucgagugggu cgucaaccgc aucaacuccg ucauggagcc ccgcggccgc     1140

gacccccgcc gcgacggcaa ggacaccguc aucggcgucc ucgacaucua cggcuucgag     1200

gucuuccccg ucaacuccuu cgagcaguuc ugcaucaacu acugcaacga gaagcuccag     1260

cagcucuuca uccagcucau ccucaagcag gagcaggagg aguacgagcg cgagggcauc     1320

accuggcagu ccgucgagua cuucaacaac gccaccaucg ucgaccucgu cgagcgcccc     1380

caccgcggca uccucgccgu ccucgacgag gccugcuccu ccgccggcac caucaccgac     1440

cgcaucuucc uccagacccu cgacaugcac caccgccacc accuccacua caccucccgc     1500

cagcucugcc ccaccgacaa gaccauggag uucggccgcg acuuccgcau caagcacuac     1560

gccggcgacg ucaccuacuc cgucgagggc uucaucgaca agaaccgcga cuuccucuuc     1620

caggacuuca agcgccuccu cuacaacucc accgacccca cccuccgcgc cauguggccc     1680

gacggccagc aggacaucac cgaggucacc aagcgccccc ucaccgccgg cacccucuuc     1740

aagaacucca uggucgcccu cgucgagaac cucgccucca aggagcccuu cuacguccgc     1800

ugcaucaagc ccaacgagga caaggucgcc ggcaagcucg acgagaacca cugccgccac     1860

caggucgccu accucggccu ccucgagaac guccgcgucc gccgcgccgg cuucgccucc     1920

cgccagcccu acucccgcuu ccuccuccgc uacaagauga ccugcgagua caccuggccc     1980

aaccaccucc ucggcuccga caaggccgcc gucuccgccc uccucgagca gcacggccuc     2040

cagggcgacg ucgccuucgg ccacuccaag cucuucaucc gcuccccccg cacccucguc     2100

acccucgagc agucccgcgc ccgccucauc cccaucaucg uccuccuccu ccagaaggcc     2160

uggcgcggca cccucgcccg cuggcgcugc cgccgccucc gcgccaucua caccaucaug     2220

cgcugguucc gccgccacaa gguccgcgcc caccucgccg agcuccagcg ccgcuuccag     2280

gccgcccgcc agcccccccu cuacggccgc gaccucgucu ggccccuccc ccccgccguc     2340

cuccagcccu uccaggacac cugccacgcc cucuucugcc gcuggcgcgc ccgccagcuc     2400

gucaagaaca ucccccccuc cgacaugccc cagaucaagg ccaaggucgc cgccaugggc     2460

gcccuccagg gccuccgcca ggacuggggc ugccgccgcg ccugggcccg cgacuaccuc     2520

uccuccgcca ccgacaaccc caccgccucc ucccucuucg cccagcgccu caagacccuc     2580

caggacaagg acggcuucgg cgccguccuc uucuccuccc acguccgcaa ggucaaccgc     2640

uuccacaaga uccgcaaccg cgcccuccuc cucaccgacc agcaccucua caagcucgac     2700

cccgaccgcc aguaccgcgu caugcgcgcc gucccccucg aggccgucac cggccucucc     2760

gucaccuccg gcggcgacca gcucgucguc cuccacgccc gcggccagga cgaccucguc     2820

gucugccucc accgcucccg ccccccccuc gacaaccgcg ucggcgagcu cgucggcguc     2880

cucgccgccc acugccaggg cgagggccgc acccucgagg uccgcgucuc cgacugcauc     2940

ccccucuccc accgcggcgu ccgccgccuc aucuccgucg agccccgccc cgagcagccc     3000

gagcccgacu uccgcugcgc ccgcggcucc uucacccucc ucuggcccuc ccgcuga        3057


<210>  2838
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1G__Homo_sapiens__CCDS34629.1

<400>  2838
auggaggacg aagagggccc cgaauacggg aagccugauu ucgugcugcu cgaccagguc       60

accauggagg auuuuaugag aaaccuucaa cugagguucg aaaaaggacg gaucuauaca      120

uacauuggug agguuuuggu gagcguaaau ccauaucagg aguuaccgcu guacggcccc      180

gaagccauag cucgcuauca ggggcgagag cuauacgaac guccuccaca ccucuaugca      240

guggccaacg cggcuuacaa ggccaugaaa cauagaucca gggacacuug caucgucauu      300

ucuggagagu caggcgcagg uaagacggag gccaguaaac acaucaugca guacauugcu      360

gcagugacca aucccagcca acgggccgaa guugagcgcg ugaaggaugu ccugcuuaag      420

uccacaugug ugcuggaagc cuuugggaac gcuagaacua auaggaacca uaauucuucg      480

cgguucggaa aauauaugga caucaacuuu gauuucaagg gcgacccuau aggcgggcac      540

auccauucau acuugcucga gaaaagccgc guacugaagc agcacguugg agaacgaaau      600

uuucacgcgu ucuaucagcu gcucagaggu agugaggaua aacaguuaca ugagcugcac      660

cuugaaagga acccagcagu guacaauuuu acccaucaag gcgccggguu gaacaugaca      720

guccacuccg cucuggacuc ugaugagcag agccaccagg ccgugaccga agcaaugcgg      780

gugauuggau ucucccccga ggaagucgag ucaguucauc guauccuagc ugccauucuc      840

caccugggca auaucgaguu uguggaaacu gaggaaggug ggcuucagaa ggagggacug      900

gcgguagccg aagaggcauu gguggaccau gucgcugagc ucacagccac cccucgcgau      960

cugguguuaa gaagucugcu cgcuaggacg guugccagcg gcggccggga acuuauagag     1020

aaggggcaca cugcagccga ggcuucuuau gcgcgagacg caugcgccaa agcuguguac     1080

caacgccugu ucgaaugggu cgugaacaga auuaauuccg uaauggagcc aaggggacgg     1140

gacccgcgca gagaugguaa ggacaccguu aucggcgugu uggauauuua uggguuugaa     1200

gucuuccccg ugaacucauu cgagcaguuu uguaucaacu acugcaauga aaaacuacag     1260

caacuguuca uccagcucau ucugaagcag gagcaggaag aguacgagag ggaaggaaua     1320

acauggcaaa gcgucgagua uuuuaacaau gccacuaucg uggaccuugu ugaacguccu     1380

caucggggca uucuggcagu guuggaugag gccuguaguu cugcugguac caucacagac     1440

cgaauauucc uccagacccu ggauaugcac cacagacauc acuuacauua cacguccagg     1500

cagcugugcc caacugacaa aacaauggaa uuugggcgcg auuuccggau uaagcacuau     1560

gccggcgacg uaaccuacag cgucgaggga uuuaucgaua aaaacagaga cuuccuauuu     1620

caggacuuca agaggcuccu guauaauucg acugauccca cacuucgcgc aauguggccu     1680

gacggccaac aggauaucac cgaggugacg aagcgaccau ugaccgcggg gacacuguuu     1740

aaaaacucua ugguugcucu cguggaaaau cuggccucca aggagcccuu cuacguccgg     1800

uguauuaaac cgaacgaaga caagguggca ggaaaacuug augagaauca cugccgucau     1860

cagguagccu aucuggguuu gcucgaaaac gugagaguua ggcgcgcugg cuuugccuca     1920

cggcagccuu acaguagauu ccuguuaagg uacaagauga cuugugagua uaccuggccc     1980

aaucaccucc uagggagcga caaggcagcu gucuccgccc uccuggagca acauggacuu     2040

cagggcgaug uggcguucgg ucacucuaaa uuguuuaucc gaagcccacg cacacuggug     2100

acucucgaac agucacgggc cagacugauu ccuauaaucg ucuuacugcu ucagaaggcu     2160

uggaggggga ccuuggcacg uuggcgcugc cggagacuca gggccauuua cacaaucaug     2220

cgaugguucc ggcgccauaa aguuagagcu caccuggccg agcuacaaag gcgguuucag     2280

gcagcgcgac agcccccacu guauggcaga gaccucgugu ggccccugcc uccagccgug     2340

cuucaaccgu uccaggauac cugucacgcu uuguuuugcc gcuggagggc ccgucagcug     2400

guaaagaaca uucccccuag ugacaugcca cagaucaaag caaaggucgc ugccauggga     2460

gcauuacaag gccuccggca ggauuggggg ugcagaaggg ccugggcucg cgacuaccug     2520

uccagcgcga cugauaaucc cacggccucu ucacuuuucg cacagcgacu gaagacauug     2580

caggacaaag acggauuugg ugcugugcug uucaguagcc auguuagaaa ggugaaccgg     2640

uuucacaaaa uaaggaaucg cgcccugcua cugaccgauc aacaucucua uaagcuggac     2700

ccugaucguc aguacagagu caugcgggcc gugccacuug aagcuguuac uggcuugucc     2760

gugaccucug ggggagacca gcugguaguc uuacacgcaa ggggccagga ugaccucgug     2820

gugugucugc aucgcucgcg acccccgcuu gauaacagag ucggugagcu gguuggggug     2880

cuagccgcgc acugccaagg cgagggacgg acacucgaag uaagggugag cgacuguauc     2940

ccucuguccc accgcggcgu cagaagguug auuucagugg agccacggcc cgaacagccu     3000

gagcccgauu uccguugcgc ucgcgggagu uuuacccugu uauggccauc ucgauga        3057


<210>  2839
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1G__Homo_sapiens__CCDS34629.1

<400>  2839
auggaggacg aggagggccc cgaguacggc aagcccgacu ucgugcugcu ggaccaggug       60

accauggagg acuucaugag aaaccugcag cugagauucg agaagggcag aaucuacacc      120

uacaucggcg aggugcuggu gagcgugaac cccuaccagg agcugccccu guacggcccc      180

gaggccaucg ccagauacca gggcagagag cuguacgaga gaccccccca ccuguacgcc      240

guggccaacg ccgccuacaa ggccaugaag cacagaagca gagacaccug caucgugauc      300

agcggcgaga gcggcgccgg caagaccgag gccagcaagc acaucaugca guacaucgcc      360

gccgugacca accccagcca gagagccgag guggagagag ugaaggacgu gcugcugaag      420

agcaccugcg ugcuggaggc cuucggcaac gccagaacca acagaaacca caacagcagc      480

agauucggca aguacaugga caucaacuuc gacuucaagg gcgaccccau cggcggccac      540

auccacagcu accugcugga gaagagcaga gugcugaagc agcacguggg cgagagaaac      600

uuccacgccu ucuaccagcu gcugagaggc agcgaggaca agcagcugca cgagcugcac      660

cuggagagaa accccgccgu guacaacuuc acccaccagg gcgccggccu gaacaugacc      720

gugcacagcg cccuggacag cgacgagcag agccaccagg ccgugaccga ggccaugaga      780

gugaucggcu ucagccccga ggagguggag agcgugcaca gaauccuggc cgccauccug      840

caccugggca acaucgaguu cguggagacc gaggagggcg gccugcagaa ggagggccug      900

gccguggccg aggaggcccu gguggaccac guggccgagc ugaccgccac ccccagagac      960

cuggugcuga gaagccugcu ggccagaacc guggccagcg gcggcagaga gcugaucgag     1020

aagggccaca ccgccgccga ggccagcuac gccagagacg ccugcgccaa ggccguguac     1080

cagagacugu ucgagugggu ggugaacaga aucaacagcg ugauggagcc cagaggcaga     1140

gaccccagaa gagacggcaa ggacaccgug aucggcgugc uggacaucua cggcuucgag     1200

guguuccccg ugaacagcuu cgagcaguuc ugcaucaacu acugcaacga gaagcugcag     1260

cagcuguuca uccagcugau ccugaagcag gagcaggagg aguacgagag agagggcauc     1320

accuggcaga gcguggagua cuucaacaac gccaccaucg uggaccuggu ggagagaccc     1380

cacagaggca uccuggccgu gcuggacgag gccugcagca gcgccggcac caucaccgac     1440

agaaucuucc ugcagacccu ggacaugcac cacagacacc accugcacua caccagcaga     1500

cagcugugcc ccaccgacaa gaccauggag uucggcagag acuucagaau caagcacuac     1560

gccggcgacg ugaccuacag cguggagggc uucaucgaca agaacagaga cuuccuguuc     1620

caggacuuca agagacugcu guacaacagc accgacccca cccugagagc cauguggccc     1680

gacggccagc aggacaucac cgaggugacc aagagacccc ugaccgccgg cacccuguuc     1740

aagaacagca ugguggcccu gguggagaac cuggccagca aggagcccuu cuacgugaga     1800

ugcaucaagc ccaacgagga caagguggcc ggcaagcugg acgagaacca cugcagacac     1860

cagguggccu accugggccu gcuggagaac gugagaguga gaagagccgg cuucgccagc     1920

agacagcccu acagcagauu ccugcugaga uacaagauga ccugcgagua caccuggccc     1980

aaccaccugc ugggcagcga caaggccgcc gugagcgccc ugcuggagca gcacggccug     2040

cagggcgacg uggccuucgg ccacagcaag cuguucauca gaagccccag aacccuggug     2100

acccuggagc agagcagagc cagacugauc cccaucaucg ugcugcugcu gcagaaggcc     2160

uggagaggca cccuggccag auggagaugc agaagacuga gagccaucua caccaucaug     2220

agaugguuca gaagacacaa ggugagagcc caccuggccg agcugcagag aagauuccag     2280

gccgccagac agcccccccu guacggcaga gaccuggugu ggccccugcc ccccgccgug     2340

cugcagcccu uccaggacac cugccacgcc cuguucugca gauggagagc cagacagcug     2400

gugaagaaca ucccccccag cgacaugccc cagaucaagg ccaagguggc cgccaugggc     2460

gcccugcagg gccugagaca ggacuggggc ugcagaagag ccugggccag agacuaccug     2520

agcagcgcca ccgacaaccc caccgccagc agccuguucg cccagagacu gaagacccug     2580

caggacaagg acggcuucgg cgccgugcug uucagcagcc acgugagaaa ggugaacaga     2640

uuccacaaga ucagaaacag agcccugcug cugaccgacc agcaccugua caagcuggac     2700

cccgacagac aguacagagu gaugagagcc gugccccugg aggccgugac cggccugagc     2760

gugaccagcg gcggcgacca gcugguggug cugcacgcca gaggccagga cgaccuggug     2820

gugugccugc acagaagcag acccccccug gacaacagag ugggcgagcu ggugggcgug     2880

cuggccgccc acugccaggg cgagggcaga acccuggagg ugagagugag cgacugcauc     2940

ccccugagcc acagaggcgu gagaagacug aucagcgugg agcccagacc cgagcagccc     3000

gagcccgacu ucagaugcgc cagaggcagc uucacccugc uguggcccag cagauga        3057


<210>  2840
<211>  3057
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1G__Homo_sapiens__CCDS34629.1

<400>  2840
auggaggacg aagagggccc cgaauacggg aagccugauu ucgugcugcu cgaccagguc       60

accauggagg auuuuaugag aaaccugcaa cuucgguucg aaaaaggacg caucuauaca      120

uacauuggcg agguucuggu gagcgugaau ccguaucagg agcucccccu guacgggccu      180

gaagccaucg cuagauauca gggacgggag cuuuacgaaa gacccccuca ccuguaugcc      240

gucgcgaacg cugccuacaa ggccaugaaa caucgcuccc gggacacgug cauugugauc      300

ucuggcgaga gcggggcugg aaagaccgag gccuccaaac acauuaugca guacaucgcu      360

gccguuacaa aucccucuca acgcgcggaa guggagagag ucaaggaugu gcuccucaag      420

agcaccugug uucuggaagc cuuuggcaac gcucggacaa aucgcaacca uaauuccucu      480

agauucggca aauauaugga caucaacuuu gauuucaagg gggacccuau uggaggccac      540

auccauagcu accugcugga gaaaucccgg gugcuuaagc agcacgucgg ggaacgcaau      600

uuucacgccu ucuaucagcu gcucagagga agcgaggaua aacagcugca ugagcuucac      660

cuggaacgga acccggcugu guacaauuuu acccaucaag gcgccgggcu caacaugaca      720

gugcacucug cgcuggacuc cgaugagcag agccaccagg ccgucaccga agcuaugcgc      780

guuauuggau ucucucccga ggaaguggag uccgugcaua gaauccuggc cgcuauucuc      840

caccugggca auaucgaguu ugucgaaacg gaggaaggcg ggcuucagaa ggagggacug      900

gccguggccg aagaggcucu cguugaccau guggcggagc ugaccgccac accucgggau      960

cuuguccuga gaagccuccu ggcucgcacc guggccucug gcgggcggga acugauugag     1020

aagggacaca cagccgcuga agccuccuau gcgagagacg cuugcgccaa agccguuuac     1080

caacgccucu ucgagugggu ggucaaccgg aucaauagcg ugauggagcc cagaggccgc     1140

gacccucgga gagaugggaa ggacaccguc aucggagugc uggauauuua uggcuuugaa     1200

guuuuccccg ugaacuccuu cgagcaguuu uguaucaacu acugcaauga aaaacuucag     1260

caacuguuca uucagcucau ccugaagcag gagcaggaag aguacgagcg cgaaggcauu     1320

acguggcaau cugucgagua uuuuaacaau gcuacaaucg uggaccuugu ugaacggccg     1380

cauagaggga uccuggccgu gcucgaugag gcuuguagcu ccgccggaac cauuacagac     1440

cgcaucuucc ugcagacccu ggauaugcac caccggcauc accuccauua caccagcaga     1500

cagcugugcc cuacagacaa aacgauggaa uuuggccggg auuuccgcau uaagcacuau     1560

gcgggggacg ucaccuacuc uguggaggga uuuaucgaua aaaacagaga cuuccuuuuu     1620

caggacuuca agcggcugcu cuauaauucc acagauccca cccugagagc cauguggccu     1680

gacggccaac aggauauuac agaggugacc aagcgccccc ugacggcugg gacacuuuuu     1740

aaaaacagca ugguugcccu cgucgaaaau cuggcuucua aggagcccuu cuacgugcgg     1800

uguaucaaac cuaacgaaga caagguggcc ggcaaacugg augagaauca cugcagacau     1860

caggucgcgu aucucggacu gcuugaaaac gugcgcguua gacgggccgg cuuugcuagc     1920

cgccagccgu acuccagauu ccugcuccgg uacaagauga ccugugagua uaccuggccc     1980

aaucaucugc uggggucuga caaggccgcu gugagcgccc uucucgagca acacggacug     2040

cagggcgaug ucgccuucgg gcacuccaaa cuguuuaucc gcagcccuag aacacucgug     2100

acccuggaac agucucgggc ucgccuuauu cccaucauug uucugcuccu gcagaaggcg     2160

uggagaggaa cacuggcccg guggcgcugc agacggcuua gagcuaucua cacgauuaug     2220

cgcugguucc ggagacauaa agugcgcgcc caccucgccg agcugcaacg gagauuucag     2280

gcugcccgcc agccuccccu guauggccgg gaccucgucu ggccgcugcc ucccgcggug     2340

cuucaaccuu uccaggauac cugucacgcu cuguuuugca gauggcgcgc ccggcagcuc     2400

guuaagaaca uucccccuuc cgacaugccc cagaucaaag ccaagguggc ugccaugggg     2460

gcgcugcaag gccugagaca ggauugggga ugccggcgcg cuugggccag agacuaccuu     2520

agcucugcca cagauaaucc gaccgcuucc agccucuucg cccagcggcu gaagacacug     2580

caggacaaag acggcuuugg ggcuguccuc uucuccucuc augugcgcaa ggugaacaga     2640

uuucacaaaa uccggaauag agcccugcuu cugaccgauc aacaucucua uaagcuggac     2700

ccugaucgcc aguaccgggu caugagagcg guuccccugg aagccgugac gggacuuagc     2760

gugaccuccg gcggggacca gcuggucgug cuccacgcuc gcggacagga ugaccugguu     2820

gugugucucc aucggucuag acccccucug gauaaccgcg ucggcgagcu uguggggguu     2880

cuggccgcuc acugccaagg cgagggacgg acacucgaag ugagagucag cgacuguauc     2940

ccgcuguccc accgcggcgu gagacggcug auuagcguug agccccgccc ugaacagccc     3000

gagccugauu ucagaugcgc ccgggggucu uuuacccuuc uguggcccuc ccgcuga        3057


<210>  2841
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MYO1H__Homo_sapiens__NP_001094891

<400>  2841

Met Glu Gly Ala Leu Thr Ala Arg Asp Lys Val Gly Val Gln Asp Phe 
1               5                   10                  15      


Val Leu Leu Asp Ala Tyr Thr Ser Glu Ser Ala Phe Val Asp Asn Leu 
            20                  25                  30          


Arg Lys Arg Phe Ser Glu Asn Leu Ile Tyr Thr Tyr Ile Gly Thr Leu 
        35                  40                  45              


Leu Val Ser Val Asn Pro Tyr Gln Glu Leu Gly Ile Tyr Thr Val Ser 
    50                  55                  60                  


Gln Met Glu Leu Tyr Gln Gly Val Asn Phe Phe Glu Leu Pro Pro His 
65                  70                  75                  80  


Val Tyr Ala Ile Ala Asp Asn Ala Tyr Arg Met Met Cys Ala Glu Leu 
                85                  90                  95      


Asn Asn His Phe Ile Leu Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
            100                 105                 110         


Glu Ala Ser Lys Lys Ile Leu Glu Tyr Phe Ala Val Thr Cys Pro Met 
        115                 120                 125             


Thr Gln Ser Leu Gln Ile Ala Arg Asp Arg Leu Leu Phe Ser Asn Pro 
    130                 135                 140                 


Val Leu Glu Ala Phe Gly Asn Ala Arg Thr Leu Arg Asn Asp Asn Ser 
145                 150                 155                 160 


Ser Arg Phe Gly Lys Tyr Met Asp Ile Gln Phe Asp Phe Gln Gly Ile 
                165                 170                 175     


Pro Val Gly Gly His Ile Ile Ser Tyr Leu Ile Glu Lys Ser Arg Val 
            180                 185                 190         


Val Tyr Gln Asn Glu Gly Glu Arg Asn Phe His Ile Phe Tyr Gln Leu 
        195                 200                 205             


Leu Ala Gly Gly Glu Glu Glu Arg Leu Ser Tyr Leu Gly Leu Glu Arg 
    210                 215                 220                 


Asp Pro Gln Leu Tyr Lys Tyr Leu Ser Gln Gly His Cys Ala Lys Glu 
225                 230                 235                 240 


Ser Ser Ile Ser Asp Lys Asn Asp Trp Lys Thr Val Ser Asn Ala Phe 
                245                 250                 255     


Ser Val Ile Asp Phe Thr Glu Ala Asp Leu Glu Asn Leu Phe Gly Ile 
            260                 265                 270         


Ile Ala Ser Val Leu His Leu Gly Asn Ile Gly Phe Glu Glu Asp Asp 
        275                 280                 285             


Gln Gly Cys Ala Thr Ile Pro Asp Thr His Glu Ile Lys Trp Ile Ala 
    290                 295                 300                 


Lys Leu Leu Gly Val His Pro Ser Val Leu Leu Glu Ala Leu Thr His 
305                 310                 315                 320 


Arg Lys Ile Glu Ala Lys Thr Glu Glu Val Ile Cys Pro Leu Thr Leu 
                325                 330                 335     


Glu Leu Ser Val Tyr Ala Arg Asp Ala Met Ala Lys Ala Val Tyr Gly 
            340                 345                 350         


Arg Thr Phe Thr Trp Leu Val Asn Lys Ile Asn Ser Ser Leu Val Asn 
        355                 360                 365             


Lys Asp Phe Thr Arg Lys Thr Val Ile Gly Leu Leu Asp Ile Tyr Gly 
    370                 375                 380                 


Phe Glu Val Phe Asp Lys Asn Gly Phe Glu Gln Phe Cys Ile Asn Tyr 
385                 390                 395                 400 


Cys Asn Glu Lys Leu Gln Gln Leu Leu Ile Glu Arg Thr Leu Lys Ala 
                405                 410                 415     


Glu Gln Ala Glu Tyr Glu Met Glu Gly Ile Glu Trp Glu Pro Ile Lys 
            420                 425                 430         


Tyr Phe Asn Asn Lys Ile Ile Cys Asp Leu Val Glu Glu Arg His Lys 
        435                 440                 445             


Gly Ile Ile Ser Ile Leu Asp Glu Glu Cys Ile Arg Pro Gly Pro Ala 
    450                 455                 460                 


Thr Asp Leu Ser Phe Leu Glu Lys Leu Glu Glu Lys Val Gly Lys His 
465                 470                 475                 480 


Ala His Phe Glu Thr Arg Lys Leu Ala Gly Pro Lys Gly Arg Lys Arg 
                485                 490                 495     


Ile Gly Trp Met Glu Phe Arg Leu Leu His Tyr Ala Gly Glu Val Thr 
            500                 505                 510         


Tyr Cys Thr Lys Gly Phe Leu Glu Lys Asn Asn Asp Leu Leu Tyr Arg 
        515                 520                 525             


His Leu Lys Glu Val Leu Cys Lys Ser Lys Asn Ile Ile Leu Arg Glu 
    530                 535                 540                 


Cys Phe Leu Leu Ala Glu Leu Glu Asn Arg Arg Arg Pro Pro Thr Val 
545                 550                 555                 560 


Gly Thr Gln Phe Lys Asn Ser Leu Ser Ser Leu Leu Glu Thr Leu Ile 
                565                 570                 575     


Ser Lys Glu Pro Ser Tyr Ile Arg Cys Ile Lys Pro Asn Asp Arg Lys 
            580                 585                 590         


Glu Pro Ser Lys Phe Asp Asp Phe Leu Ile Arg His Gln Ile Lys Tyr 
        595                 600                 605             


Leu Gly Leu Met Glu His Leu Arg Val Arg Arg Ala Gly Phe Ala Tyr 
    610                 615                 620                 


Arg Arg Lys Tyr Glu His Phe Leu Gln Arg Tyr Lys Ser Leu Cys Pro 
625                 630                 635                 640 


Asp Thr Trp Pro His Trp His Gly Pro Pro Ala Glu Gly Val Glu Arg 
                645                 650                 655     


Leu Ile Lys Tyr Ile Gly Tyr Lys Pro Glu Glu Tyr Lys Leu Gly Lys 
            660                 665                 670         


Thr Lys Ile Phe Ile Arg Phe Pro Arg Thr Leu Phe Ala Thr Glu Asp 
        675                 680                 685             


Ala Phe Glu Phe Ser Lys His Gln Leu Val Ala Arg Ile Gln Ala Thr 
    690                 695                 700                 


Tyr Lys Arg Cys Leu Gly Arg Arg Glu Tyr Val Lys Lys Arg Gln Ala 
705                 710                 715                 720 


Ala Ile Lys Leu Glu Ala His Trp Arg Gly Ala Leu Ala Arg Lys Ala 
                725                 730                 735     


Ile Gln Arg Arg Lys Trp Ala Val Arg Ile Ile Arg Lys Phe Ile Lys 
            740                 745                 750         


Gly Phe Ile Ser Arg Asn Lys Pro Leu Cys Pro Asp Asn Glu Glu Phe 
        755                 760                 765             


Ile Val Phe Val Arg Lys Asn Tyr Ile Leu Asn Leu Arg Tyr His Leu 
    770                 775                 780                 


Pro Lys Thr Val Leu Asp Lys Ser Trp Leu Arg Pro Pro Gly Ile Leu 
785                 790                 795                 800 


Glu Asn Ala Ser Asp Leu Leu Arg Lys Met Cys Val Arg Asn Leu Val 
                805                 810                 815     


Gln Lys Tyr Cys Arg Gly Ile Thr Ala Glu Arg Lys Ala Met Met Gln 
            820                 825                 830         


Gln Lys Val Val Thr Ser Glu Ile Phe Arg Gly Arg Lys Asp Gly Tyr 
        835                 840                 845             


Thr Glu Ser Leu Asn Gln Pro Phe Val Asn Ser Arg Ile Asp Glu Gly 
    850                 855                 860                 


Asp Ile Asn Pro Lys Val Leu Gln Leu Ile Ser His Glu Lys Ile Gln 
865                 870                 875                 880 


Tyr Gly Val Pro Val Ile Lys Tyr Asp Arg Lys Gly Phe Lys Ala Arg 
                885                 890                 895     


Gln Arg Gln Leu Ile Leu Thr Gln Lys Ala Ala Tyr Val Val Glu Leu 
            900                 905                 910         


Ala Lys Ile Lys Gln Lys Ile Glu Tyr Ser Ala Leu Lys Gly Val Ser 
        915                 920                 925             


Thr Ser Asn Leu Ser Asp Gly Ile Leu Val Ile His Val Ser Pro Glu 
    930                 935                 940                 


Asp Ser Lys Gln Lys Gly Asp Ala Val Leu Gln Cys Gly His Val Phe 
945                 950                 955                 960 


Glu Ala Val Thr Lys Leu Val Met Leu Val Lys Lys Glu Asn Ile Val 
                965                 970                 975     


Asn Val Val Gln Gly Ser Leu Gln Phe Phe Ile Ser Pro Gly Lys Glu 
            980                 985                 990         


Gly Thr Ile Val Phe Asp Thr Gly Leu Glu Glu Gln Val Tyr Lys Asn 
        995                 1000                1005            


Lys Asn Gly Gln Leu Thr Val Val Ser Val Arg Arg Lys Ser 
    1010                1015                1020        


<210>  2842
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MYO1H__Homo_sapiens__CCDS53826.1

<400>  2842
auggaagggg cgcugacugc ccgggacaag gucgggguuc aggauuuugu gcuauuggac       60

gcguacacca gcgaaucugc cuuugucgac aaccuccgca agcguuucag cgagaaccuc      120

auauacacau auauuggcac ccuccuugug ucugugaauc cauaccagga gcucggaauc      180

uacacuguga gccagaugga acuuuaucaa ggggucaauu ucuuugaacu gccaccacau      240

gucuacgcua uagccgacaa cgcuuaccga augaugugug cugaacuaaa uaaccauuuc      300

auccucauuu cuggagagag uggggcaggg aaaacagagg ccuccaagaa aauucucgag      360

uauuuugcag ugaccugccc aaugacccag ucacuacaaa uagcccguga cagacugcug      420

uucuccaacc cagugcugga ggcuuuugga aaugccagaa cgcuccggaa ugacaacucc      480

agcagauuug ggaaauacau ggauauacaa uuugauuuuc agggcauucc cguagguggg      540

cauaucauca guuacuugau agagaagucc cgaguugucu accaaaacga aggcgagcgg      600

aauuuccaca ucuucuacca gcugcuggca gguggcgaag aggagcgccu gucuuaccug      660

ggacucgagc gagaccccca gcuguauaaa uaccucucac agggucauug ugccaaagag      720

ucauccauua gugacaagaa ugacuggaaa acuguuucca acgccuuuuc ugucauugau      780

uuuacugaag cugaccucga gaaucucuuu ggaauuauug ccagugucuu acaccugggg      840

aacauugguu uugaagaaga cgaccaaggc ugugccacua ucccagacac ccaugagauc      900

aaguggauag ccaagcuccu ggggguccac ccaucagucc uucuggaagc ucucacccac      960

agaaaaauug aagccaaaac ugaggaggug aucugcccgu ugacacuaga acucucuguc     1020

uacgcuagag augcaauggc aaaggcuguu uauggacgaa cguuuacuug gcuggucaac     1080

aaaaucaauu ccuccuuagu uaacaaggau uucaccagga aaacuguaau uggauuacug     1140

gacaucuaug gguuugaagu cuuugacaag aaugguuuug aacaguucug uauaaauuac     1200

ugcaaugaga aacuccagca acuguuaauu gagaggacuc uaaaagcaga acaggcagaa     1260

uaugaaaugg aaggcauaga gugggagcca auuaaauauu ucaacaacaa gaucaucugu     1320

gauuugguag aagagagaca uaaaggaauc auaucuauuc uggaugaaga augcauucgg     1380

ccugguccug cuacagacuu gaguuuccug gagaaauugg aagagaaagu gggcaaacau     1440

gcacacuucg aaacccguaa gcuggcuggu ccaaagggcc gaaagaggau uggcuggaug     1500

gaguuccgac uccuccacua ugcaggagag gucacauacu gcaccaaggg auucuuggaa     1560

aaaaacaaug aucuucuuua cagacaucug aaagaagugc ugugcaaguc caagaacauu     1620

auccugaggg aaugcuuccu gcuggccgag uuagaaaacc ggaggaggcc cccaacagug     1680

gggacucagu uuaaaaacag ucugagcagc cuucuagaaa cccucaucuc uaaggagccc     1740

uccuacaucc guugcaucaa gcccaacgac aggaaagaac ccagcaaauu ugaugacuuc     1800

cucauaaggc aucagaucaa auaccugggg cugauggagc accugcgggu gagacgggcu     1860

gguuuugcau accgaaggaa auacgagcau uucuugcaaa gguacaaguc cuuaugccca     1920

gacaccuggc cgcacuggca cgggccucca gcagagggcg uggaacggcu gaucaaguac     1980

aucggcuaca aacccgagga auacaaguua ggcaaaacca aaauauucau ucguuucccc     2040

agaacucugu uugcuaccga agaugccuuu gaauuuagua aacaucaacu aguugcaaga     2100

auccaagcca cuuacaaacg cugccuagga aggagagaau acgugaaaaa aagacaagca     2160

gccaucaaac uggaagccca cuggcguggg gcccuggcuc ggaaggcaau ccaaaggaga     2220

aagugggccg ugcggauuau cagaaaguuc auuaaaggau ucaucagucg caacaaaccc     2280

cucuguccug acaacgagga auuuaucgug uuugugcgga agaauuacau cuugaaucuc     2340

cgguaucacc uuccaaagac uguccuggac aagagcuggc ugaggccucc uggcaucuug     2400

gaaaaugcau cagaucugcu caggaaaaug ugcgugagga accuggugca gaaguacugc     2460

cgcgggauca cagcugagcg gaaagcaaug augcagcaaa agguaguuac aagugaaauc     2520

uucaggggaa ggaaagacgg cuacacagaa aguuuaaauc aacccuuugu caacagucgg     2580

auagaugaag gagacauuaa uccgaaagug cuucagcuaa uuagccauga gaaaauccag     2640

uauggugucc cggucauuaa auaugacaga aaaggcuuca aagcacggca gcggcaacuc     2700

auucuuacuc agaaagcagc uuacguggug gaacuugcca aaaucaagca gaaaauagag     2760

uacucagcuc ucaaaggugu cuccacuagc aaucugagug auggaaucuu agucauucau     2820

guuucaccag aggacagcaa gcaaaagggg gaugccguuu ugcagugugg acacguguuu     2880

gaagcaguua cuaaacucgu caugcugguu aagaaggaga acauugucaa uguuguucaa     2940

ggaaguuuac aguuuuuuau uaguccggga aaagaaggca caauaguuuu cgacacugga     3000

cuggaagaac aagucuauaa aaauaaaaau ggacaauuaa cagugguguc aguccggagg     3060

aaguccuga                                                             3069


<210>  2843
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MYO1H__Homo_sapiens__CCDS53826.1

<400>  2843
auggagggcg cccugaccgc ccgcgacaag gugggggucc aggacuucgu gcuccuggac       60

gcguacacca gcgaguccgc cuucguggac aaccugcgga agcgcuucag cgagaaccuc      120

aucuacacgu acaucggcac ccugcugguc uccgugaacc ccuaccagga gcucgggauc      180

uacaccguga gccagaugga gcuguaccag ggcgucaacu ucuucgagcu gccgccccac      240

guguacgcca ucgccgacaa cgccuaccgg augaugugcg cggagcucaa caaccacuuc      300

auccugaucu ccggggagag cggcgccggc aagaccgagg ccuccaagaa gauccuggag      360

uacuucgccg ugacgugccc caugacccag agccuccaga ucgcgcgcga ccggcugcug      420

uucuccaacc ccguccucga ggccuucggg aacgcccgca cccugcggaa cgacaacagc      480

ucccgcuucg gcaaguacau ggacauccag uucgacuucc aggggauccc ggugggcggg      540

cacaucauca gcuaccugau cgagaagucc cggguggucu accagaacga gggcgagcgc      600

aacuuccaca ucuucuacca gcuccuggcc ggcggggagg aggagcggcu gagcuaccuc      660

ggccuggagc gcgaccccca gcuguacaag uaccucuccc aggggcacug cgccaaggag      720

agcuccauca gcgacaagaa cgacuggaag accgugucca acgcguucag cgugaucgac      780

uucacggagg ccgaccugga gaaccuguuc ggcaucaucg ccagcguccu ccaccugggc      840

aacaucgggu ucgaggagga cgaccagggc ugcgccacca uccccgacac ccacgagauc      900

aaguggaucg ccaagcugcu cggggugcac cccuccgugc ugcuggaggc gcucacccac      960

cggaagaucg aggccaagac ggaggagguc aucugcccgc ugacccugga gcucagcgug     1020

uacgcccgcg acgccauggc caaggcggug uacggccgga ccuucaccug gcuggucaac     1080

aagaucaacu ccagccuggu gaacaaggac uucacgcgca agaccgugau cgggcuccug     1140

gacaucuacg gcuucgaggu cuucgacaag aacggcuucg agcaguucug caucaacuac     1200

ugcaacgaga agcugcagca gcuccugauc gagcggaccc ugaaggccga gcaggccgag     1260

uacgagaugg aggggaucga gugggagccc aucaaguacu ucaacaacaa gaucaucugc     1320

gaccucgugg aggagcgcca caagggcauc aucuccaucc uggacgagga gugcauccgg     1380

cccgggcccg ccaccgaccu gagcuuccuc gagaagcugg aggagaaggu cggcaagcac     1440

gcccacuucg agacgcgcaa gcuggcgggg ccgaagggcc ggaagcgcau cggcuggaug     1500

gaguuccgcc ugcuccacua cgccggggag gugaccuacu gcaccaaggg cuuccuggag     1560

aagaacaacg accugcucua ccggcaccug aaggaggugc ugugcaaguc caagaacauc     1620

auccuccgcg agugcuuccu gcuggccgag cucgagaacc ggcgccggcc gcccaccguc     1680

gggacgcagu ucaagaacag ccuguccagc cugcucgaga cccugaucuc caaggagccc     1740

agcuacaucc gcugcaucaa gcccaacgac cggaaggagc ccuccaaguu cgacgacuuc     1800

cugauccgcc accagaucaa guaccucggc cugauggagc accuccgggu gcgccgggcc     1860

ggguucgcgu accgccggaa guacgagcac uuccugcagc gcuacaagag ccugugcccc     1920

gacaccuggc cccacuggca cggcccgccc gccgagggcg uggagcggcu gaucaaguac     1980

aucggguaca agcccgagga guacaagcuc ggcaagacca agaucuucau ccgcuucccc     2040

cggacgcugu ucgccaccga ggacgccuuc gaguucucca agcaccagcu ggucgcccgc     2100

auccaggcga ccuacaagcg gugccucggg cgccgcgagu acgugaagaa gcggcaggcc     2160

gccaucaagc uggaggccca cuggcgcggc gcccuggcgc ggaaggccau ccagcgccgg     2220

aagugggccg ugcgcaucau ccggaaguuc aucaagggcu ucaucagccg caacaagccg     2280

cucugccccg acaacgagga guucaucguc uucgugcgga agaacuacau ccugaaccug     2340

cgcuaccacc uccccaagac cgugcuggac aaguccuggc ugcggccccc ggggauccuc     2400

gagaacgcca gcgaccugcu gcgcaagaug ugcguccgga accucgugca gaaguacugc     2460

cgcggcauca cggccgagcg gaaggcgaug augcagcaga agguggucac cuccgagauc     2520

uuccgcgggc ggaaggacgg cuacaccgag agccugaacc agcccuucgu gaacagccgc     2580

aucgacgagg gggacaucaa ccccaaggug cugcagcuca ucucccacga gaagauccag     2640

uacggcgucc cggugaucaa guacgaccgg aagggcuuca aggcccgcca gcggcagcug     2700

auccugaccc agaaggccgc cuacgugguc gagcucgcga agaucaagca gaagaucgag     2760

uacagcgccc ugaagggggu guccacgagc aaccuguccg acggcauccu cgugauccac     2820

gucagccccg aggacuccaa gcagaagggg gacgccgugc ugcagugcgg ccacguguuc     2880

gaggccguca ccaagcuggu gaugcucgug aagaaggaga acaucgucaa cguggugcag     2940

gggagccugc aguucuucau cucccccggc aaggagggca ccaucgucuu cgacaccggg     3000

cuggaggagc aggucuacaa gaacaagaac ggccagcuca ccguggugag cgugcgccgc     3060

aaguccuga                                                             3069


<210>  2844
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MYO1H__Homo_sapiens__CCDS53826.1

<400>  2844
auggagggcg cccucaccgc ccgcgacaag gucggcgucc aggacuucgu ccuccucgac       60

gccuacaccu ccgaguccgc cuucgucgac aaccuccgca agcgcuucuc cgagaaccuc      120

aucuacaccu acaucggcac ccuccucguc uccgucaacc ccuaccagga gcucggcauc      180

uacaccgucu cccagaugga gcucuaccag ggcgucaacu ucuucgagcu ccccccccac      240

gucuacgcca ucgccgacaa cgccuaccgc augaugugcg ccgagcucaa caaccacuuc      300

auccucaucu ccggcgaguc cggcgccggc aagaccgagg ccuccaagaa gauccucgag      360

uacuucgccg ucaccugccc caugacccag ucccuccaga ucgcccgcga ccgccuccuc      420

uucuccaacc ccguccucga ggccuucggc aacgcccgca cccuccgcaa cgacaacucc      480

ucccgcuucg gcaaguacau ggacauccag uucgacuucc agggcauccc cgucggcggc      540

cacaucaucu ccuaccucau cgagaagucc cgcgucgucu accagaacga gggcgagcgc      600

aacuuccaca ucuucuacca gcuccucgcc ggcggcgagg aggagcgccu cuccuaccuc      660

ggccucgagc gcgaccccca gcucuacaag uaccucuccc agggccacug cgccaaggag      720

uccuccaucu ccgacaagaa cgacuggaag accgucucca acgccuucuc cgucaucgac      780

uucaccgagg ccgaccucga gaaccucuuc ggcaucaucg ccuccguccu ccaccucggc      840

aacaucggcu ucgaggagga cgaccagggc ugcgccacca uccccgacac ccacgagauc      900

aaguggaucg ccaagcuccu cggcguccac cccuccgucc uccucgaggc ccucacccac      960

cgcaagaucg aggccaagac cgaggagguc aucugccccc ucacccucga gcucuccguc     1020

uacgcccgcg acgccauggc caaggccguc uacggccgca ccuucaccug gcucgucaac     1080

aagaucaacu ccucccucgu caacaaggac uucacccgca agaccgucau cggccuccuc     1140

gacaucuacg gcuucgaggu cuucgacaag aacggcuucg agcaguucug caucaacuac     1200

ugcaacgaga agcuccagca gcuccucauc gagcgcaccc ucaaggccga gcaggccgag     1260

uacgagaugg agggcaucga gugggagccc aucaaguacu ucaacaacaa gaucaucugc     1320

gaccucgucg aggagcgcca caagggcauc aucuccaucc ucgacgagga gugcauccgc     1380

cccggccccg ccaccgaccu cuccuuccuc gagaagcucg aggagaaggu cggcaagcac     1440

gcccacuucg agacccgcaa gcucgccggc cccaagggcc gcaagcgcau cggcuggaug     1500

gaguuccgcc uccuccacua cgccggcgag gucaccuacu gcaccaaggg cuuccucgag     1560

aagaacaacg accuccucua ccgccaccuc aaggaggucc ucugcaaguc caagaacauc     1620

auccuccgcg agugcuuccu ccucgccgag cucgagaacc gccgccgccc ccccaccguc     1680

ggcacccagu ucaagaacuc ccucuccucc cuccucgaga cccucaucuc caaggagccc     1740

uccuacaucc gcugcaucaa gcccaacgac cgcaaggagc ccuccaaguu cgacgacuuc     1800

cucauccgcc accagaucaa guaccucggc cucauggagc accuccgcgu ccgccgcgcc     1860

ggcuucgccu accgccgcaa guacgagcac uuccuccagc gcuacaaguc ccucugcccc     1920

gacaccuggc cccacuggca cggccccccc gccgagggcg ucgagcgccu caucaaguac     1980

aucggcuaca agcccgagga guacaagcuc ggcaagacca agaucuucau ccgcuucccc     2040

cgcacccucu ucgccaccga ggacgccuuc gaguucucca agcaccagcu cgucgcccgc     2100

auccaggcca ccuacaagcg cugccucggc cgccgcgagu acgucaagaa gcgccaggcc     2160

gccaucaagc ucgaggccca cuggcgcggc gcccucgccc gcaaggccau ccagcgccgc     2220

aagugggccg uccgcaucau ccgcaaguuc aucaagggcu ucaucucccg caacaagccc     2280

cucugccccg acaacgagga guucaucguc uucguccgca agaacuacau ccucaaccuc     2340

cgcuaccacc uccccaagac cguccucgac aaguccuggc uccgcccccc cggcauccuc     2400

gagaacgccu ccgaccuccu ccgcaagaug ugcguccgca accucgucca gaaguacugc     2460

cgcggcauca ccgccgagcg caaggccaug augcagcaga aggucgucac cuccgagauc     2520

uuccgcggcc gcaaggacgg cuacaccgag ucccucaacc agcccuucgu caacucccgc     2580

aucgacgagg gcgacaucaa ccccaagguc cuccagcuca ucucccacga gaagauccag     2640

uacggcgucc ccgucaucaa guacgaccgc aagggcuuca aggcccgcca gcgccagcuc     2700

auccucaccc agaaggccgc cuacgucguc gagcucgcca agaucaagca gaagaucgag     2760

uacuccgccc ucaagggcgu cuccaccucc aaccucuccg acggcauccu cgucauccac     2820

gucucccccg aggacuccaa gcagaagggc gacgccgucc uccagugcgg ccacgucuuc     2880

gaggccguca ccaagcucgu caugcucguc aagaaggaga acaucgucaa cgucguccag     2940

ggcucccucc aguucuucau cucccccggc aaggagggca ccaucgucuu cgacaccggc     3000

cucgaggagc aggucuacaa gaacaagaac ggccagcuca ccgucgucuc cguccgccgc     3060

aaguccuga                                                             3069


<210>  2845
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MYO1H__Homo_sapiens__CCDS53826.1

<400>  2845
auggagggcg cccugaccgc uagagacaag gugggggucc aggauuucgu ucuccuugac       60

gcauacacaa gcgaauccgc cuuuguggau aaccugagga aacgguucuc ugagaauuug      120

aucuauacuu acauuggaac guuacuggua ucagugaacc ccuaucaaga acuagguaua      180

uacaccguca gucagaugga gcucuaucag ggcgugaacu uuuucgaacu gccuccacac      240

guuuacgcga ucgcugacaa ugccuaucgc augaugugcg cagagcuuaa uaaccauuuu      300

auucugauca gcggggaguc cggagccggc aagacagagg cuucuaaaaa gauuuuggag      360

uacuucgcag ugacuugucc gaugacccag ucgcuccaaa ucgcccgaga ucgucugcug      420

uuuucaaauc ccguccucga ggcuuucggu aacgccagaa cauuaaggaa ugacaacagc      480

agucgguuug ggaaauacau ggauauacag uucgacuuuc agggaauccc ugugggcggc      540

cacauuaucu ccuaucugau ugagaagucu cgcguaguuu accagaauga gggggaaaga      600

aacuuccaua ucuuuuauca acuuuuggcg ggaggugagg aagagaggcu gagcuaccua      660

ggccucgaac gggauccaca gcuguauaag uaccuuuccc aggggcacug cgcaaaagag      720

ucaaguauaa gcgacaagaa ugauuggaaa accgugucua acgccuucuc cgucauugac      780

uucacugagg cugaucugga aaauuuguuu ggaaucauug ccucagugcu ccaucugggc      840

aacaucgguu ucgaggaaga cgaccagggg ugugcaacaa uccccgauac ccacgagauu      900

aaguggauag cuaaauuacu gggagugcac ccuagcgucc uccuugaagc ccugacgcau      960

cgcaagaucg aggcgaagac ugaggaaguu auuugcccau ugacccuaga gcugagugug     1020

uaugcccgag acgcaauggc uaaagccgua uacggcagaa cauuuacuug gcucgugaac     1080

aagaucaauu cuucccuggu caacaaagau uucaccagga agacagugau aggccuucug     1140

gacauuuacg gguuugaagu uuucgauaaa aauggauuug agcaauucug uaucaacuau     1200

ugcaaugaaa aguugcagca gcuccugauc gagcggaccu uaaaagcuga gcaagccgaa     1260

uacgagaugg aagguauuga gugggagccc aucaaguauu uuaacaauaa gauuauaugu     1320

gaccuggugg aagaacguca caaaggcauc auuagcaucc uagaugaaga gugcauccgc     1380

ccugggccag caacggaccu cucguuccug gaaaaacuug aggagaaagu cggaaagcau     1440

gcccacuuug aaacuagaaa auuggcuggc ccgaagggua ggaagcggau uggguggaug     1500

gaguuccgac ugcuccacua cgcgggcgaa gugacauauu guaccaaagg auuucuggag     1560

aagaacaaug aucuucugua ccgccauuug aaagaaguac ucugcaaguc uaaaaacaua     1620

auccugagag aguguuucuu acuggcagag cuagaaaaua ggcggcgacc cccuacuguu     1680

ggcacacagu ucaagaacuc ccucucaagu cugcuugaga ccuugauuag caaggaacca     1740

uccuauauca gaugcauuaa acccaaugac aggaaggagc cuucuaaauu ugaugacuuc     1800

cugauccguc accagauaaa guaccucggg cugauggaac auuuacgggu gcgcagagcc     1860

ggauuugcuu acaggcgcaa auaugagcac uuccugcagc gguacaagag ccuuugccca     1920

gacacguggc cccauuggca cgguccgccu gccgagggcg ucgaaagauu gaucaaguau     1980

auuggguaca aacccgagga auauaagcuc ggaaaaacca agaucuuuau uagguuccca     2040

cgcacacugu uugcaacuga ggaugccuuc gaguuuucaa aacaccagcu aguggcucga     2100

auccaagcca ccuacaagcg gugucugggc cguagagaau augucaaaaa gaggcaggca     2160

gcgauaaagc ucgaggcuca uuggcgcggu gcccuggcac ggaaagccau ucagagaagg     2220

aagugggcug ugcgaaucau ucgcaaauuc aucaaggggu uuauaagucg gaacaaaccu     2280

cuuugccccg acaaugaaga guucaucguu uuugugagaa agaacuacau uuugaaccug     2340

agguaccacu uaccaaagac aguacucgau aaauccuggc ugcguccccc uggcauccuu     2400

gaaaaugcca gcgaccuguu gcgcaagaug uguguccgga accucgugca aaaauauugc     2460

agaggaauua cugcagagag gaaggcuaug augcagcaga aaguugugac cucugagauc     2520

uuccgaggcc ggaaggaugg guacacagaa ucacugaauc agccauucgu caacagucgc     2580

auagacgagg gagauauuaa uccgaaggug cuacaacuga ucagccauga aaagauccag     2640

uaugguguac ccgugauuaa guacgacaga aaaggcuuua aggccaggca gcggcagcuc     2700

auccugaccc aaaaagcggc cuauguuguc gagcuugcua agauuaagca gaaaauagaa     2760

uacuccgcau ugaagggggu gucuacuucg aaccugagcg auggaaucuu agugauucac     2820

gucuccccug aggacucaaa acagaagggc gaugccguuc uccaaugugg ucacguguuc     2880

gaggcuguga cgaaacuggu aaugcuuguc aagaaagaaa auaucgugaa cguugugcag     2940

gggagucugc aguuuuucau uucuccaggc aaggagggaa caaucgucuu ugacaccggc     3000

cuagaagaac agguguauaa gaauaaaaac gggcaacuca cuguugugag cguacgaaga     3060

aaguccuga                                                             3069


<210>  2846
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MYO1H__Homo_sapiens__CCDS53826.1

<400>  2846
auggagggcg cccugaccgc cagagacaag gugggcgugc aggacuucgu gcugcuggac       60

gccuacacca gcgagagcgc cuucguggac aaccugagaa agagauucag cgagaaccug      120

aucuacaccu acaucggcac ccugcuggug agcgugaacc ccuaccagga gcugggcauc      180

uacaccguga gccagaugga gcuguaccag ggcgugaacu ucuucgagcu gcccccccac      240

guguacgcca ucgccgacaa cgccuacaga augaugugcg ccgagcugaa caaccacuuc      300

auccugauca gcggcgagag cggcgccggc aagaccgagg ccagcaagaa gauccuggag      360

uacuucgccg ugaccugccc caugacccag agccugcaga ucgccagaga cagacugcug      420

uucagcaacc ccgugcugga ggccuucggc aacgccagaa cccugagaaa cgacaacagc      480

agcagauucg gcaaguacau ggacauccag uucgacuucc agggcauccc cgugggcggc      540

cacaucauca gcuaccugau cgagaagagc agaguggugu accagaacga gggcgagaga      600

aacuuccaca ucuucuacca gcugcuggcc ggcggcgagg aggagagacu gagcuaccug      660

ggccuggaga gagaccccca gcuguacaag uaccugagcc agggccacug cgccaaggag      720

agcagcauca gcgacaagaa cgacuggaag accgugagca acgccuucag cgugaucgac      780

uucaccgagg ccgaccugga gaaccuguuc ggcaucaucg ccagcgugcu gcaccugggc      840

aacaucggcu ucgaggagga cgaccagggc ugcgccacca uccccgacac ccacgagauc      900

aaguggaucg ccaagcugcu gggcgugcac cccagcgugc ugcuggaggc ccugacccac      960

agaaagaucg aggccaagac cgaggaggug aucugccccc ugacccugga gcugagcgug     1020

uacgccagag acgccauggc caaggccgug uacggcagaa ccuucaccug gcuggugaac     1080

aagaucaaca gcagccuggu gaacaaggac uucaccagaa agaccgugau cggccugcug     1140

gacaucuacg gcuucgaggu guucgacaag aacggcuucg agcaguucug caucaacuac     1200

ugcaacgaga agcugcagca gcugcugauc gagagaaccc ugaaggccga gcaggccgag     1260

uacgagaugg agggcaucga gugggagccc aucaaguacu ucaacaacaa gaucaucugc     1320

gaccuggugg aggagagaca caagggcauc aucagcaucc uggacgagga gugcaucaga     1380

cccggccccg ccaccgaccu gagcuuccug gagaagcugg aggagaaggu gggcaagcac     1440

gcccacuucg agaccagaaa gcuggccggc cccaagggca gaaagagaau cggcuggaug     1500

gaguucagac ugcugcacua cgccggcgag gugaccuacu gcaccaaggg cuuccuggag     1560

aagaacaacg accugcugua cagacaccug aaggaggugc ugugcaagag caagaacauc     1620

auccugagag agugcuuccu gcuggccgag cuggagaaca gaagaagacc ccccaccgug     1680

ggcacccagu ucaagaacag ccugagcagc cugcuggaga cccugaucag caaggagccc     1740

agcuacauca gaugcaucaa gcccaacgac agaaaggagc ccagcaaguu cgacgacuuc     1800

cugaucagac accagaucaa guaccugggc cugauggagc accugagagu gagaagagcc     1860

ggcuucgccu acagaagaaa guacgagcac uuccugcaga gauacaagag ccugugcccc     1920

gacaccuggc cccacuggca cggccccccc gccgagggcg uggagagacu gaucaaguac     1980

aucggcuaca agcccgagga guacaagcug ggcaagacca agaucuucau cagauucccc     2040

agaacccugu ucgccaccga ggacgccuuc gaguucagca agcaccagcu gguggccaga     2100

auccaggcca ccuacaagag augccugggc agaagagagu acgugaagaa gagacaggcc     2160

gccaucaagc uggaggccca cuggagaggc gcccuggcca gaaaggccau ccagagaaga     2220

aagugggccg ugagaaucau cagaaaguuc aucaagggcu ucaucagcag aaacaagccc     2280

cugugccccg acaacgagga guucaucgug uucgugagaa agaacuacau ccugaaccug     2340

agauaccacc ugcccaagac cgugcuggac aagagcuggc ugagaccccc cggcauccug     2400

gagaacgcca gcgaccugcu gagaaagaug ugcgugagaa accuggugca gaaguacugc     2460

agaggcauca ccgccgagag aaaggccaug augcagcaga agguggugac cagcgagauc     2520

uucagaggca gaaaggacgg cuacaccgag agccugaacc agcccuucgu gaacagcaga     2580

aucgacgagg gcgacaucaa ccccaaggug cugcagcuga ucagccacga gaagauccag     2640

uacggcgugc ccgugaucaa guacgacaga aagggcuuca aggccagaca gagacagcug     2700

auccugaccc agaaggccgc cuacguggug gagcuggcca agaucaagca gaagaucgag     2760

uacagcgccc ugaagggcgu gagcaccagc aaccugagcg acggcauccu ggugauccac     2820

gugagccccg aggacagcaa gcagaagggc gacgccgugc ugcagugcgg ccacguguuc     2880

gaggccguga ccaagcuggu gaugcuggug aagaaggaga acaucgugaa cguggugcag     2940

ggcagccugc aguucuucau cagccccggc aaggagggca ccaucguguu cgacaccggc     3000

cuggaggagc agguguacaa gaacaagaac ggccagcuga ccguggugag cgugagaaga     3060

aagagcuga                                                             3069


<210>  2847
<211>  3069
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MYO1H__Homo_sapiens__CCDS53826.1

<400>  2847
auggagggcg cccugaccgc uagagacaag gugggggucc aggauuucgu ucuccuggac       60

gccuacacaa gcgaauccgc guuuguggau aaccuucgga aacgcuucuc ugagaaucug      120

aucuauacgu acauuggaac ccuccuggug agcgucaacc ccuaucaaga acuuggcauc      180

uacacagugu cccagaugga gcuguaucag gggguuaacu uuuucgaacu cccuccgcac      240

guguacgcua uugccgacaa ugccuauaga augaugugcg cugagcugaa uaaccauuuu      300

auccugauuu cuggagagag cggcgccggg aagaccgagg cuuccaaaaa gauccucgag      360

uacuucgccg ucacaugucc caugacccag ucucugcaaa ucgcgcggga ucgccuucug      420

uuuagcaauc cugugcucga agccuucgga aacgcuagaa cacugcggaa ugacaacucc      480

agccgcuuug gcaaauacau ggauauucag uucgacuuuc agggcauccc cguuggggga      540

cacauuaucu cuuaucuuau ugagaagucc agaguggucu accagaauga gggcgaacgg      600

aacuuccaua ucuuuuauca acugcucgcc gggggagagg aagaacgccu gagcuaccug      660

ggccucgaaa gagauccuca gcuguauaag uaccuuucuc aggggcacug cgcuaaagag      720

uccagcauuu cugacaagaa ugauuggaaa accgugucca acgccuucag cgugaucgac      780

uucacggagg cggaucugga aaaucucuuu ggaaucauug ccuccguccu gcaucuuggc      840

aacaucggcu ucgaggaaga cgaccagggg ugugcuacca uucccgauac acacgagauc      900

aaguggauug ccaaacugcu cggaguucac ccuucugugc ugcuggaagc ucucacccau      960

cggaagaucg aggccaagac agaggaagug aucugcccgc ugacccuuga gcugagcguc     1020

uaugcccgcg acgcuauggc gaaagccgug uacggcagaa cguuuacaug gcucguuaac     1080

aagauuaauu ccagccuggu gaacaaagau uucacccgga agacagucau cgggcuucug     1140

gacauuuacg gauuugaagu guucgauaaa aauggcuuug agcaauucug uaucaacuau     1200

ugcaaugaaa agcuccagca gcugcugauu gagcgcaccc ucaaagcuga gcaagccgaa     1260

uacgagaugg aagggaucga gugggagccc aucaaguauu uuaacaauaa gauuaucugu     1320

gaccugguug aagagagaca caaaggaauu aucucuauuc uugaugaaga gugcauccgg     1380

ccuggccccg ccaccgaccu guccuuccuc gaaaagcugg aggagaaagu gggcaagcau     1440

gcucacuuug aaacaagaaa acuggccggg ccuaagggac gcaagcggau uggcuggaug     1500

gaguucagac uucuccacua cgcgggggaa gucacguauu guaccaaagg auuucuggag     1560

aagaacaaug aucugcucua ccgccaucug aaagaagugc uuugcaagag caaaaacauc     1620

auccugcggg aguguuuccu ccuggcugag cuggaaaaua gacgccggcc cccgacaguc     1680

ggcacccagu ucaagaacuc ucuuagcucc cuccuggaga cacugauuuc uaaggaaccu     1740

agcuauauca gaugcauuaa acccaaugac cgcaaggagc cuuccaaauu ugaugacuuc     1800

cucauccggc accagauuaa guaccugggg cuuauggaac aucugagagu gcgccgggcc     1860

ggcuuugccu acagacggaa auaugagcac uuccuccagc gcuacaagag ccugugcccc     1920

gacaccuggc cccauuggca cggaccuccg gcugagggcg uugaaagacu gaucaaguau     1980

aucggguaca aacccgagga auauaaacuu ggaaaaacga agauuuuuau ccgguucccu     2040

agaacacucu uugccaccga ggaugcuuuc gaguuuucua aacaccaacu gguggcccgc     2100

auucaggcga ccuacaagcg gugucugggc agacgcgaau augucaaaaa gagacaggcc     2160

gcuaucaagc ucgaggccca uuggcgcggg gcucuggccc ggaaagcgau ucagagacgg     2220

aagugggccg ugcgcaucau cagaaaauuc auuaagggau uuaucucccg gaacaaaccc     2280

cuuugcccug acaaugaaga guucauuguu uuugugcgca agaacuacau ccugaaccuc     2340

agauaccauc ugcccaagac aguccuggau aaaagcuggc uucggccgcc uggcauucuc     2400

gaaaaugcuu cugaccugcu gcgcaagaug ugugugagaa accucgugca aaaauauugc     2460

cgggggauca ccgccgagag aaaggcuaug augcagcaga aaguugucac auccgagauc     2520

uuccgcggcc ggaaggaugg auacacggaa agccugaauc agcccuucgu gaacuccaga     2580

auugacgagg gcgauaucaa uccuaaggug cuucaacuga uuucucacga aaagauccag     2640

uauggggucc ccgugauuaa guacgaccgc aaaggauuua aggcccggca gagacagcuc     2700

auccugaccc aaaaagccgc uuauguugug gagcuggcga agauuaagca gaaaaucgaa     2760

uacagcgccc uuaagggcgu cuccacaucu aaccugagcg augggauccu cgugauucac     2820

guuuccccug aggacagcaa acagaaggga gaugcugugc ugcaaugugg ccacgucuuc     2880

gaggccguga ccaaacucgu uaugcuggug aagaaagaaa auaucgucaa cguggugcag     2940

gggucucuuc aguuuuucau uucccccggc aaggagggaa caaucgucuu ugacaccggc     3000

cuggaggaac agguuuauaa gaauaaaaac gggcaacuca cgguggugag cguccgccgg     3060

aagucuuga                                                             3069


<210>  2848
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NA17__Homo_sapiens__Q3V5L5

<400>  2848

Met Ile Thr Val Asn Pro Asp Gly Lys Ile Met Val Arg Arg Cys Leu 
1               5                   10                  15      


Val Thr Leu Arg Pro Phe Arg Leu Phe Val Leu Gly Ile Gly Phe Phe 
            20                  25                  30          


Thr Leu Cys Phe Leu Met Thr Ser Leu Gly Gly Gln Phe Ser Ala Arg 
        35                  40                  45              


Arg Leu Gly Asp Ser Pro Phe Thr Ile Arg Thr Glu Val Met Gly Gly 
    50                  55                  60                  


Pro Glu Ser Arg Gly Val Leu Arg Lys Met Ser Asp Leu Leu Glu Leu 
65                  70                  75                  80  


Met Val Lys Arg Met Asp Ala Leu Ala Arg Leu Glu Asn Ser Ser Glu 
                85                  90                  95      


Leu His Arg Ala Gly Gly Asp Leu His Phe Pro Ala Asp Arg Met Pro 
            100                 105                 110         


Pro Gly Ala Gly Leu Met Glu Arg Ile Gln Ala Ile Ala Gln Asn Val 
        115                 120                 125             


Ser Asp Ile Ala Val Lys Val Asp Gln Ile Leu Arg His Ser Leu Leu 
    130                 135                 140                 


Leu His Ser Lys Val Ser Glu Gly Arg Arg Asp Gln Cys Glu Ala Pro 
145                 150                 155                 160 


Ser Asp Pro Lys Phe Pro Asp Cys Ser Gly Lys Val Glu Trp Met Arg 
                165                 170                 175     


Ala Arg Trp Thr Ser Asp Pro Cys Tyr Ala Phe Phe Gly Val Asp Gly 
            180                 185                 190         


Thr Glu Cys Ser Phe Leu Ile Tyr Leu Ser Glu Val Glu Trp Phe Cys 
        195                 200                 205             


Pro Pro Leu Pro Trp Arg Asn Gln Thr Ala Ala Gln Arg Ala Pro Lys 
    210                 215                 220                 


Pro Leu Pro Lys Val Gln Ala Val Phe Arg Ser Asn Leu Ser His Leu 
225                 230                 235                 240 


Leu Asp Leu Met Gly Ser Gly Lys Glu Ser Leu Ile Phe Met Lys Lys 
                245                 250                 255     


Arg Thr Lys Arg Leu Thr Ala Gln Trp Ala Leu Ala Ala Gln Arg Leu 
            260                 265                 270         


Ala Gln Lys Leu Gly Ala Thr Gln Arg Asp Gln Lys Gln Ile Leu Val 
        275                 280                 285             


His Ile Gly Phe Leu Thr Glu Glu Ser Gly Asp Val Phe Ser Pro Arg 
    290                 295                 300                 


Val Leu Lys Gly Gly Pro Leu Gly Glu Met Val Gln Trp Ala Asp Ile 
305                 310                 315                 320 


Leu Thr Ala Leu Tyr Val Leu Gly His Gly Leu Arg Val Thr Val Ser 
                325                 330                 335     


Leu Lys Glu Leu Gln Ser Asn Leu Gly Val Pro Pro Gly Arg Gly Ser 
            340                 345                 350         


Cys Pro Leu Thr Met Pro Leu Pro Phe Asp Leu Ile Tyr Thr Asp Tyr 
        355                 360                 365             


His Gly Leu Gln Gln Met Lys Arg His Met Gly Leu Ser Phe Lys Lys 
    370                 375                 380                 


Tyr Arg Cys Arg Ile Arg Val Ile Asp Thr Phe Gly Thr Glu Pro Ala 
385                 390                 395                 400 


Tyr Asn His Glu Glu Tyr Ala Thr Leu His Gly Tyr Arg Thr Asn Trp 
                405                 410                 415     


Gly Tyr Trp Asn Leu Asn Pro Lys Gln Phe Met Thr Met Phe Pro His 
            420                 425                 430         


Thr Pro Asp Asn Ser Phe Met Gly Phe Val Ser Glu Glu Leu Asn Glu 
        435                 440                 445             


Thr Glu Lys Arg Leu Ile Lys Gly Gly Lys Ala Ser Asn Met Ala Val 
    450                 455                 460                 


Val Tyr Gly Lys Glu Ala Ser Ile Trp Lys Leu Gln Gly Lys Glu Lys 
465                 470                 475                 480 


Phe Leu Gly Ile Leu Asn Lys Tyr Met Glu Ile His Gly Thr Val Tyr 
                485                 490                 495     


Tyr Glu Ser Gln Arg Pro Pro Glu Val Pro Ala Phe Val Lys Asn His 
            500                 505                 510         


Gly Leu Leu Pro Gln Pro Glu Phe Gln Gln Leu Leu Arg Lys Ala Lys 
        515                 520                 525             


Leu Phe Ile Gly Phe Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu 
    530                 535                 540                 


Ala Ile Ala Asn Gly Cys Ile Phe Leu Gln Ser Arg Phe Ser Pro Pro 
545                 550                 555                 560 


His Ser Ser Leu Asn His Glu Phe Phe Arg Gly Lys Pro Thr Ser Arg 
                565                 570                 575     


Glu Val Phe Ser Gln His Pro Tyr Ala Glu Asn Phe Ile Gly Lys Pro 
            580                 585                 590         


His Val Trp Thr Val Asp Tyr Asn Asn Ser Glu Glu Phe Glu Ala Ala 
        595                 600                 605             


Ile Lys Ala Ile Met Arg Thr Gln Val Asp Pro Tyr Leu Pro Tyr Glu 
    610                 615                 620                 


Tyr Thr Cys Glu Gly Met Leu Glu Arg Ile His Ala Tyr Ile Gln His 
625                 630                 635                 640 


Gln Asp Phe Cys Arg Ala Pro Asp Pro Ala Leu Pro Glu Ala His Ala 
                645                 650                 655     


Pro Gln Ser Pro Phe Val Leu Ala Pro Asn Ala Thr His Leu Glu Trp 
            660                 665                 670         


Ala Arg Asn Thr Ser Leu Ala Pro Gly Ala Trp Pro Pro Ala His Ala 
        675                 680                 685             


Leu Arg Ala Trp Leu Ala Val Pro Gly Arg Ala Cys Thr Asp Thr Cys 
    690                 695                 700                 


Leu Asp His Gly Leu Ile Cys Glu Pro Ser Phe Phe Pro Phe Leu Asn 
705                 710                 715                 720 


Ser Gln Asp Ala Phe Leu Lys Leu Gln Val Pro Cys Asp Ser Thr Glu 
                725                 730                 735     


Ser Glu Met Asn His Leu Tyr Pro Ala Phe Ala Gln Pro Gly Gln Glu 
            740                 745                 750         


Cys Tyr Leu Gln Lys Glu Pro Leu Leu Phe Ser Cys Ala Gly Ser Asn 
        755                 760                 765             


Thr Lys Tyr Arg Arg Leu Cys Pro Cys Arg Asp Phe Arg Lys Gly Gln 
    770                 775                 780                 


Val Ala Leu Cys Gln Gly Cys Leu 
785                 790         


<210>  2849
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NA17__Homo_sapiens__BAC84969

<400>  2849
augaucaccg ucaaccccga ugggaagaua auggucagaa gaugccuggu cacccugaga       60

cccuuucggc uuuuuguccu gggcaucggc uucuucacuc ucugcuuccu gaugacgucu      120

cugggaggcc aguucucggc ccggcgccug ggggacucgc cauucaccau ccgcacagaa      180

gugauggggg gccccgaguc ccgcggcguc cugcgcaaga ugagcgaccu gcuggagcug      240

auggugaagc gcauggacgc acuggccagg cuggagaaca gcagugagcu gcaccgggcc      300

ggcggcgacc ugcacuuucc cgcagacagg augcccccug gggccggccu cauggagcgg      360

auccaggcua uugcccagaa cgucuccgac aucgcuguga agguggacca gauccugcgc      420

cacagucugc uccugcacag caagguguca gaaggccggc gggaccagug ugaggcaccc      480

agugacccca aguucccuga cugcucaggg aagguggagu ggaugcgugc ccgcuggacc      540

ucugaccccu gcuacgccuu cuuuggggug gacggcaccg agugcuccuu ccucaucuac      600

cucagugagg ucgagugguu cugccccccg cugcccugga ggaaccagac ggcugcccag      660

agggcaccca agccccuccc caaaguccag gcaguuuucc gaagcaaccu gucccaccuu      720

cuggaccuga ugggcagcgg gaaggagucc cugaucuuca ugaagaagcg gaccaagagg      780

cucacagccc agugggcgcu ggcugcccag cgccuggcac agaagcuggg ggccacccag      840

agggaccaga agcagauccu gguccacauc ggcuuccuga cggaggaguc cggggacgug      900

uucagcccuc ggguccugaa gggcgggccc cuaggggaga uggugcagug ggcggacauu      960

cugacugcac ucuauguccu gggccauggc cugcggguca cagucucccu gaaggagcug     1020

cagaguaacu uagggguacc gccaggccgg ggaagcugcc cgcucaccau gccccugccc     1080

uucgaccuca ucuacaccga cuaccacggc cugcagcaga ugaagcggca caugggacuc     1140

uccuucaaga aguaccggug ccgaaucagg gucaucgaca ccuucgggac ggaaccugcg     1200

uacaaccacg aggaguacgc cacgcugcac ggcuaccgga ccaacugggg cuacuggaac     1260

cucaacccca agcaguucau gaccauguuu ccucauaccc ccgacaacuc cuucaugggc     1320

uucguguccg aggagcucaa cgagacggag aagcggcuca ucaaaggcgg caaggccagc     1380

aacauggccg ugguguacgg caaggaggcg agcaucugga agcuccaggg gaaggagaag     1440

uuccugggca uccugaacaa auacauggag auccauggca ccguguacua cgagagccag     1500

cggccccccg aggugccagc cuuugugaag aaccacggcc ucuuaccgca gccugaguuu     1560

cagcagcugc ugcgcaaggc caaacucuuc aucggguuug gcuuccccua cgagggcccc     1620

gccccccugg aggccaucgc caaugguugc aucuuccugc agucccgcuu cagcccgccc     1680

cacagcuccc ucaaccacga guucuuccga ggcaagccca ccuccagaga gguguucucc     1740

cagcaucccu acgcggagaa cuucaucggc aagccccacg uguggacagu cgacuacaac     1800

aacucagagg aguuugaagc agccaucaag gccauuauga gaacucaggu agaccccuac     1860

cuacccuaug aguacaccug cgaggggaug cuggagcgga uccacgccua cauccagcac     1920

caggacuucu gcagagcucc agacccugcc cuaccagagg cccacgcccc gcagagcccc     1980

uuuguccugg cccccaaugc cacccaccuc gagugggcuc ggaacaccag cuuggcuccu     2040

ggggccuggc cccccgcgca cgcccugcgg gccuggcugg ccgugccugg gagggccugc     2100

accgacaccu gccuggacca cgggcuaauc ugugagcccu ccuucuuccc cuuccugaac     2160

agccaggacg ccuuccucaa gcugcaggug cccugugaca gcaccgaguc ggagaugaac     2220

caccuguacc cggcguucgc ccagccuggc caggagugcu accugcagaa ggagccucug     2280

cucuucagcu gcgccggcuc caacaccaag uaccgccggc ucugccccug ccgcgacuuc     2340

cgcaagggcc agguggccuu gugccagggc ugucuguga                            2379


<210>  2850
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NA17__Homo_sapiens__BAC84969

<400>  2850
augaucaccg ugaaccccga cggcaagauc augguccgcc ggugccuggu gacccuccgc       60

ccguuccggc uguucgugcu ggggaucggc uucuucacgc ucugcuuccu gaugaccagc      120

cucgggggcc aguucuccgc ccgccggcug ggggacagcc ccuucaccau ccgcaccgag      180

gucaugggcg gccccgaguc ccgcggggug cugcgcaaga ugagcgaccu gcucgagcug      240

auggugaagc ggauggacgc ccuggcgcgc cucgagaacu ccagcgagcu gcaccgggcc      300

ggcggggacc ugcacuuccc cgccgaccgc augccgcccg gcgccgggcu cauggagcgg      360

auccaggcca ucgcgcagaa cgucuccgac aucgccguga agguggacca gauccugcgc      420

cacagccugc uccugcacuc caaggucagc gagggccggc gcgaccagug cgaggccccc      480

uccgacccca aguucccgga cugcagcggc aagguggagu ggaugcgggc ccgcuggacg      540

uccgaccccu gcuacgcguu cuucggggug gacggcaccg agugcagcuu ccugaucuac      600

cucuccgagg ucgagugguu cugcccgccc cugcccuggc ggaaccagac cgccgcccag      660

cgcgccccca agccccugcc caaggugcag gccguguucc ggagcaaccu cucccaccuc      720

cuggaccuga uggggagcgg caaggagucc cugaucuuca ugaagaagcg caccaagcgc      780

cugacggcgc agugggcccu cgccgcccag cggcuggccc agaagcuggg cgcgacccag      840

cgcgaccaga agcagauccu cguccacauc ggguuccuga ccgaggagag cggcgacgug      900

uucagcccgc gggugcugaa gggcgggccc cucggggaga ugguccagug ggccgacauc      960

cugaccgccc uguacgugcu cggccacggc cugcgcguga cggucucccu gaaggagcuc     1020

cagagcaacc ugggggugcc gcccggccgg ggguccugcc cccugaccau gccccucccc     1080

uucgaccuga ucuacaccga cuaccacggc cugcagcaga ugaagcgcca cauggggcuc     1140

agcuucaaga aguaccggug ccgcauccgg gugaucgaca ccuucggcac ggagcccgcc     1200

uacaaccacg aggaguacgc cacccugcac ggcuaccgca ccaacugggg guacuggaac     1260

cugaacccga agcaguucau gaccauguuc ccccacacgc ccgacaacuc cuucaugggc     1320

uucgucagcg aggagcugaa cgagaccgag aagcggcuca ucaagggcgg gaaggcgucc     1380

aacauggccg uggucuacgg gaaggaggcc agcaucugga agcugcaggg caaggagaag     1440

uuccugggca uccucaacaa guacauggag auccacggga ccguguacua cgagucccag     1500

cggcccccgg aggugcccgc cuucgucaag aaccacggcc ugcugcccca gccggaguuc     1560

cagcagcucc ugcggaaggc caagcuguuc aucggguucg gcuuccccua cgagggcccc     1620

gcgccccucg aggccaucgc caacgggugc aucuuccugc agagccgcuu cuccccgccc     1680

cacagcuccc ugaaccacga guucuuccgg ggcaagccca ccagccgcga gguguucucc     1740

cagcaccccu acgccgagaa cuucaucggg aagccgcacg uguggacggu cgacuacaac     1800

aacagcgagg aguucgaggc ggccaucaag gccaucaugc ggacccaggu ggaccccuac     1860

cuccccuacg aguacacgug cgagggcaug cuggagcgca uccacgccua cauccagcac     1920

caggacuucu gccgggcccc cgacccggcg cugcccgagg cccacgcgcc ccaguccccc     1980

uucgugcucg ccccgaacgc cacccaccug gagugggccc gcaacaccag ccuggccccc     2040

ggggccuggc cgcccgccca cgcccuccgc gcguggcugg ccguccccgg ccgggccugc     2100

accgacacgu gccuggacca cggccucauc ugcgagcccu ccuucuuccc cuuccugaac     2160

agccaggacg ccuuccugaa gcuccaggug cccugcgaca gcaccgaguc cgagaugaac     2220

caccuguacc cggcguucgc ccagcccggg caggagugcu accugcagaa ggagccccuc     2280

cuguucagcu gcgccggcuc caacaccaag uaccgccggc ugugcccgug ccgcgacuuc     2340

cggaagggcc agguggcccu cugccagggg ugccuguga                            2379


<210>  2851
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NA17__Homo_sapiens__BAC84969

<400>  2851
augaucaccg ucaaccccga cggcaagauc augguccgcc gcugccucgu cacccuccgc       60

cccuuccgcc ucuucguccu cggcaucggc uucuucaccc ucugcuuccu caugaccucc      120

cucggcggcc aguucuccgc ccgccgccuc ggcgacuccc ccuucaccau ccgcaccgag      180

gucaugggcg gccccgaguc ccgcggcguc cuccgcaaga uguccgaccu ccucgagcuc      240

auggucaagc gcauggacgc ccucgcccgc cucgagaacu ccuccgagcu ccaccgcgcc      300

ggcggcgacc uccacuuccc cgccgaccgc augccccccg gcgccggccu cauggagcgc      360

auccaggcca ucgcccagaa cgucuccgac aucgccguca aggucgacca gauccuccgc      420

cacucccucc uccuccacuc caaggucucc gagggccgcc gcgaccagug cgaggccccc      480

uccgacccca aguuccccga cugcuccggc aaggucgagu ggaugcgcgc ccgcuggacc      540

uccgaccccu gcuacgccuu cuucggcguc gacggcaccg agugcuccuu ccucaucuac      600

cucuccgagg ucgagugguu cugccccccc cuccccuggc gcaaccagac cgccgcccag      660

cgcgccccca agccccuccc caagguccag gccgucuucc gcuccaaccu cucccaccuc      720

cucgaccuca ugggcuccgg caaggagucc cucaucuuca ugaagaagcg caccaagcgc      780

cucaccgccc agugggcccu cgccgcccag cgccucgccc agaagcucgg cgccacccag      840

cgcgaccaga agcagauccu cguccacauc ggcuuccuca ccgaggaguc cggcgacguc      900

uucucccccc gcguccucaa gggcggcccc cucggcgaga ugguccagug ggccgacauc      960

cucaccgccc ucuacguccu cggccacggc cuccgcguca ccgucucccu caaggagcuc     1020

caguccaacc ucggcguccc ccccggccgc ggcuccugcc cccucaccau gccccucccc     1080

uucgaccuca ucuacaccga cuaccacggc cuccagcaga ugaagcgcca caugggccuc     1140

uccuucaaga aguaccgcug ccgcauccgc gucaucgaca ccuucggcac cgagcccgcc     1200

uacaaccacg aggaguacgc cacccuccac ggcuaccgca ccaacugggg cuacuggaac     1260

cucaacccca agcaguucau gaccauguuc ccccacaccc ccgacaacuc cuucaugggc     1320

uucgucuccg aggagcucaa cgagaccgag aagcgccuca ucaagggcgg caaggccucc     1380

aacauggccg ucgucuacgg caaggaggcc uccaucugga agcuccaggg caaggagaag     1440

uuccucggca uccucaacaa guacauggag auccacggca ccgucuacua cgagucccag     1500

cgcccccccg agguccccgc cuucgucaag aaccacggcc uccuccccca gcccgaguuc     1560

cagcagcucc uccgcaaggc caagcucuuc aucggcuucg gcuuccccua cgagggcccc     1620

gccccccucg aggccaucgc caacggcugc aucuuccucc agucccgcuu cucccccccc     1680

cacuccuccc ucaaccacga guucuuccgc ggcaagccca ccucccgcga ggucuucucc     1740

cagcaccccu acgccgagaa cuucaucggc aagccccacg ucuggaccgu cgacuacaac     1800

aacuccgagg aguucgaggc cgccaucaag gccaucaugc gcacccaggu cgaccccuac     1860

cuccccuacg aguacaccug cgagggcaug cucgagcgca uccacgccua cauccagcac     1920

caggacuucu gccgcgcccc cgaccccgcc cuccccgagg cccacgcccc ccaguccccc     1980

uucguccucg cccccaacgc cacccaccuc gagugggccc gcaacaccuc ccucgccccc     2040

ggcgccuggc cccccgccca cgcccuccgc gccuggcucg ccguccccgg ccgcgccugc     2100

accgacaccu gccucgacca cggccucauc ugcgagcccu ccuucuuccc cuuccucaac     2160

ucccaggacg ccuuccucaa gcuccagguc cccugcgacu ccaccgaguc cgagaugaac     2220

caccucuacc ccgccuucgc ccagcccggc caggagugcu accuccagaa ggagccccuc     2280

cucuucuccu gcgccggcuc caacaccaag uaccgccgcc ucugccccug ccgcgacuuc     2340

cgcaagggcc aggucgcccu cugccagggc ugccucuga                            2379


<210>  2852
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NA17__Homo_sapiens__BAC84969

<400>  2852
augaucaccg ugaaccccga cggcaagauu auggucagaa ggugccuggu uacacuccgg       60

ccuuuccgcc uuuuugugcu ggggauagga uucuuuacuu uguguuucuu aaugacgagc      120

cuggguggcc aguuuuccgc ccgacgucua ggggauucuc cauucaccau cagaacagag      180

guaaugggag gcccggaauc aaggggugug cuccggaaaa ugagugaccu gcuugagcug      240

auggucaagc gcauggaugc uuuggcaaga cucgaaaaua gcuccgagcu gcacagggcc      300

gggggagacc ugcauuuucc cgcggaucgg augccuccag gcgcuggccu cauggaacgc      360

auucaagcca ucgcacagaa cgugucugac auugccguua aaguggauca gaucuuacga      420

cacucgcugc uuuugcauuc aaaggucagc gaggggagaa gggaccagug cgaggcuccc      480

agugauccua aauucccaga cuguuccgga aagguggaau ggaugcgggc acguuggacu      540

ucugaucccu gcuacgccuu uuucggugua gacggcaccg aguguagcuu ucugauauau      600

cuauccgaag uugagugguu cugcccucca cucccguggc gcaaucaaac agcugcccag      660

agagcgccca agccucugcc aaaagugcag gcagucuuua ggucaaaccu uagucaccug      720

uuggaucuca uggggagcgg aaaggagucu cugaucuuca ugaaaaagcg gaccaaacga      780

uuaacugccc agugggcucu ggccgcacaa cgccucgcuc agaagcuggg cgccacacag      840

agagaccaga agcaaauucu ggugcauauc gguuucuuga ccgaagaguc cggggacgug      900

uuuucaccca ggguccuaaa aggaggcccu cugggcgaaa ugguucagug ggcggauauu      960

cucacggccc uguacgugcu ugggcacgga cugcggguaa cugugagcuu gaaggagcuc     1020

cagaguaauc uggguguccc acccggccgc gggucuuguc cguuaaccau gccucugccc     1080

uucgaccuaa ucuauacaga uuaccacgga cuccaacaga ugaaaagaca uaugggccug     1140

uccuuuaaga aauauaggug ccguauacgg gugauugaca cuuucgguac cgaaccagca     1200

uacaaccacg aggaguaugc uacacuucau ggguaccgaa ccaauugggg cuacuggaac     1260

uugaauccua agcaguuuau gacgauguuc ccccacacuc cagauaacag cuuuauggga     1320

uucguuucgg aggaacugaa ugaaacagag aaaagacuca ucaagggcgg gaaggccucu     1380

aacauggcug uggucuaugg aaaagaagcc uccauuugga agcugcaggg uaaagagaag     1440

uuucuuggca uccugaauaa auacauggag auccacggga ccguguauua cgaaucacaa     1500

aggcccccug agguaccagc auucguuaag aaccauggau ugcucccgca gcccgaauuu     1560

cagcagcugu uacgcaaggc caaacuguuc auuggcuuug guuucccuua ugaggggcca     1620

gcuccccuag aagcgauagc aaauggcugu aucuuccucc aaagucgguu uagcccucca     1680

cacuccucuc ugaaccauga guucuuuaga ggaaagccca cuagcaggga gguguucuca     1740

cagcacccgu acgccgaaaa cuuuauuggc aaaccucaug ucuggacagu ggacuauaau     1800

aacagugagg aauuugaggc ugccaucaag gcaauaaugc gcacccaggu cgauccauac     1860

cuucccuacg aguauacgug cgaagggaug uuggagcgga uucacgccua cauccagcac     1920

caagacuuuu gucgagcucc ugaucccgcc cugccagaag cacaugcgcc ucaguccccc     1980

uucgugcucg cuccaaaugc cacccaccug gagugggcac guaacacaag ccuggccccg     2040

ggagcuuggc cucccgccca ugcacugaga gcuuggcuug ccguuccagg uagggcgugc     2100

acugauaccu gcuuggacca cggccucauc ugugaacccu cuuucuuccc uuuucuuaau     2160

ucacaggacg ccuuccuaaa auuacaggug ccaugcgaca guacagagag cgagaugaac     2220

caccucuauc ccgcuuuugc acaaccuggg caggaauguu accugcagaa ggagccgcuu     2280

uuguucuccu gcgccggauc uaauacuaag uaucgccggc uguguccaug cagagauuuc     2340

aggaaaggcc aaguagcuuu augucagggu ugccucuga                            2379


<210>  2853
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NA17__Homo_sapiens__BAC84969

<400>  2853
augaucaccg ugaaccccga cggcaagauc auggugagaa gaugccuggu gacccugaga       60

cccuucagac uguucgugcu gggcaucggc uucuucaccc ugugcuuccu gaugaccagc      120

cugggcggcc aguucagcgc cagaagacug ggcgacagcc ccuucaccau cagaaccgag      180

gugaugggcg gccccgagag cagaggcgug cugagaaaga ugagcgaccu gcuggagcug      240

auggugaaga gaauggacgc ccuggccaga cuggagaaca gcagcgagcu gcacagagcc      300

ggcggcgacc ugcacuuccc cgccgacaga augccccccg gcgccggccu gauggagaga      360

auccaggcca ucgcccagaa cgugagcgac aucgccguga agguggacca gauccugaga      420

cacagccugc ugcugcacag caaggugagc gagggcagaa gagaccagug cgaggccccc      480

agcgacccca aguuccccga cugcagcggc aagguggagu ggaugagagc cagauggacc      540

agcgaccccu gcuacgccuu cuucggcgug gacggcaccg agugcagcuu ccugaucuac      600

cugagcgagg uggagugguu cugccccccc cugcccugga gaaaccagac cgccgcccag      660

agagccccca agccccugcc caaggugcag gccguguuca gaagcaaccu gagccaccug      720

cuggaccuga ugggcagcgg caaggagagc cugaucuuca ugaagaagag aaccaagaga      780

cugaccgccc agugggcccu ggccgcccag agacuggccc agaagcuggg cgccacccag      840

agagaccaga agcagauccu ggugcacauc ggcuuccuga ccgaggagag cggcgacgug      900

uucagcccca gagugcugaa gggcggcccc cugggcgaga uggugcagug ggccgacauc      960

cugaccgccc uguacgugcu gggccacggc cugagaguga ccgugagccu gaaggagcug     1020

cagagcaacc ugggcgugcc ccccggcaga ggcagcugcc cccugaccau gccccugccc     1080

uucgaccuga ucuacaccga cuaccacggc cugcagcaga ugaagagaca caugggccug     1140

agcuucaaga aguacagaug cagaaucaga gugaucgaca ccuucggcac cgagcccgcc     1200

uacaaccacg aggaguacgc cacccugcac ggcuacagaa ccaacugggg cuacuggaac     1260

cugaacccca agcaguucau gaccauguuc ccccacaccc ccgacaacag cuucaugggc     1320

uucgugagcg aggagcugaa cgagaccgag aagagacuga ucaagggcgg caaggccagc     1380

aacauggccg ugguguacgg caaggaggcc agcaucugga agcugcaggg caaggagaag     1440

uuccugggca uccugaacaa guacauggag auccacggca ccguguacua cgagagccag     1500

agaccccccg aggugcccgc cuucgugaag aaccacggcc ugcugcccca gcccgaguuc     1560

cagcagcugc ugagaaaggc caagcuguuc aucggcuucg gcuuccccua cgagggcccc     1620

gccccccugg aggccaucgc caacggcugc aucuuccugc agagcagauu cagccccccc     1680

cacagcagcc ugaaccacga guucuucaga ggcaagccca ccagcagaga gguguucagc     1740

cagcaccccu acgccgagaa cuucaucggc aagccccacg uguggaccgu ggacuacaac     1800

aacagcgagg aguucgaggc cgccaucaag gccaucauga gaacccaggu ggaccccuac     1860

cugcccuacg aguacaccug cgagggcaug cuggagagaa uccacgccua cauccagcac     1920

caggacuucu gcagagcccc cgaccccgcc cugcccgagg cccacgcccc ccagagcccc     1980

uucgugcugg cccccaacgc cacccaccug gagugggcca gaaacaccag ccuggccccc     2040

ggcgccuggc cccccgccca cgcccugaga gccuggcugg ccgugcccgg cagagccugc     2100

accgacaccu gccuggacca cggccugauc ugcgagccca gcuucuuccc cuuccugaac     2160

agccaggacg ccuuccugaa gcugcaggug cccugcgaca gcaccgagag cgagaugaac     2220

caccuguacc ccgccuucgc ccagcccggc caggagugcu accugcagaa ggagccccug     2280

cuguucagcu gcgccggcag caacaccaag uacagaagac ugugccccug cagagacuuc     2340

agaaagggcc agguggcccu gugccagggc ugccuguga                            2379


<210>  2854
<211>  2379
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NA17__Homo_sapiens__BAC84969

<400>  2854
augaucaccg ugaaccccga cggcaagauu auggucagac ggugccuggu uacacuccgc       60

ccuuucagac uguuugugcu ugggaucgga uucuuuacgc uguguuuccu caugaccagc      120

cugggcgggc aguuuuccgc ccggcgccuu ggagauucuc cguucacaau uagaaccgag      180

gugaugggcg ggcccgaaag ccggggaguc cugcgcaaaa uguccgaccu ccuggagcug      240

auggugaaga gaauggaugc ucucgcccgg cuggaaaauu cuagcgagcu ucaccgcgcg      300

ggcggcgacc ugcauuuucc ugcugauaga augcccccug gggccggacu cauggaacgg      360

auccaagcca uugcucagaa cguuuccgac aucgccguga aagucgauca gauccugcgc      420

cacucucuuc ugcuccauag caaggugucc gagggcagac gggaccagug cgaggcuccc      480

agcgauccua aauucccgga cuguucuggg aagguugaau ggaugcgcgc cagauggaca      540

uccgaucccu gcuacgcguu uuucggagug gacggcaccg aguguagcuu ucugauuuau      600

cugucugaag ucgagugguu cugcccuccc cucccuuggc ggaaucaaac agccgcucag      660

agagccccca agccgcugcc uaaagugcag gcuguguuuc gcuccaaccu uagccaucug      720

cucgaucuga uggggucugg aaaggagucc cuuaucuuca ugaaaaagcg gaccaaaaga      780

cugacggccc agugggcgcu cgccgcucaa cgccuggccc agaagcuggg cgcuacccag      840

cgggaccaga agcaaauucu cguccacauc ggcuuccuga cagaagagag cggggacguu      900

uucuccccca gagugcuuaa aggaggcccu cugggggaaa uggugcagug ggccgauauu      960

cucaccgccc uguacguccu uggacacggc cugcgcguga caguuucucu caaggagcug     1020

cagagcaauc ugggggugcc ucccggacgg ggcuccuguc cccucaccau gccgcugccc     1080

uucgaccuua ucuauacgga uuaccacggc cugcaacaga ugaaaagaca uauggggcuc     1140

agcuuuaaga aauaucgcug ccggauuaga gucaucgaca cauucggaac cgaaccugcu     1200

uacaaccacg aggaguaugc gacacugcau ggcuaccgca ccaauugggg guacuggaac     1260

cugaauccca agcaguuuau gaccauguuc ccucacacac ccgauaacuc uuuuauggga     1320

uucguguccg aggaacuuaa ugaaacggag aaacggcuca ucaagggcgg gaaggccagc     1380

aacauggcug uuguguaugg caaagaagcc ucuauuugga agcugcaggg aaaagagaag     1440

uuucugggca uccucaauaa auacauggag auucacggga ccgucuauua cgaaagccaa     1500

agaccgccug aggugcccgc cuucgucaag aaccauggac ugcuuccuca gcccgaauuu     1560

cagcagcugc uccggaaggc uaaacuguuc aucggcuuug gguucccuua ugagggaccc     1620

gccccgcugg aagcgauugc uaauggcugu aucuuccuuc aaucccgcuu uucuccuccc     1680

cacagcuccc ucaaccauga guucuuuaga gggaagccca caagccggga gguguucucu     1740

cagcacccuu acgccgaaaa cuuuaucggc aaaccgcaug uuuggaccgu ggacuauaau     1800

aacuccgagg aauuugaggc cgcuauuaag gccaucauga gaacacaggu cgaucccuac     1860

cugccuuacg aguauaccug cgaaggaaug cuggagcgca uucacgcuua cauccagcac     1920

caagacuuuu gucgggcccc cgauccugcg cuccccgaag cccaugcucc ucagagcccc     1980

uucgugcugg ccccgaaugc uacgcaccuu gagugggcca gaaacacauc ucuggcgccu     2040

ggcgccuggc ccccugcuca ugcccuccgc gcuuggcugg ccguucccgg gagagccugc     2100

accgauaccu gccuggacca cggacuuauu ugugaaccgu ccuuuuuccc uuuucucaau     2160

agccaggacg cuuuccugaa acuccaggug cccugcgacu ccacagaguc ugagaugaac     2220

caccuguauc cugcguuugc ccaacccggc caggaauguu accugcagaa ggagccccuu     2280

cuguucagcu gcgcuggguc caauaccaag uaucggcgcc ucuguccuug cagagauuuc     2340

cggaaaggac aagucgcccu gugucagggc ugccuguga                            2379


<210>  2855
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NA88-A__Homo_sapiens__10790436

<400>  2855

Met Thr Gln Gly Gln His Phe Leu Gln Lys Val 
1               5                   10      


<210>  2856
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NA88-A__Homo_sapiens__AF164963.1

<400>  2856
augacucaag gacagcacuu ccugcagaaa gucuag                                 36


<210>  2857
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NA88-A__Homo_sapiens__AF164963.1

<400>  2857
augacccagg gccagcacuu ccugcagaag guguga                                 36


<210>  2858
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NA88-A__Homo_sapiens__AF164963.1

<400>  2858
augacccagg gccagcacuu ccuccagaag gucuga                                 36


<210>  2859
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NA88-A__Homo_sapiens__AF164963.1

<400>  2859
augacccagg gccaacacuu ccugcagaag guguga                                 36


<210>  2860
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NA88-A__Homo_sapiens__AF164963.1

<400>  2860
augacccagg gccagcacuu ccugcagaag guguga                                 36


<210>  2861
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NA88-A__Homo_sapiens__AF164963.1

<400>  2861
augacccagg gccaacacuu ccugcagaag guguga                                 36


<210>  2862
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Neo-PAP__Homo_sapiens__Q9BWT3

<400>  2862

Met Lys Glu Met Ser Ala Asn Thr Val Leu Asp Ser Gln Arg Gln Gln 
1               5                   10                  15      


Lys His Tyr Gly Ile Thr Ser Pro Ile Ser Leu Ala Ser Pro Lys Glu 
            20                  25                  30          


Ile Asp His Ile Tyr Thr Gln Lys Leu Ile Asp Ala Met Lys Pro Phe 
        35                  40                  45              


Gly Val Phe Glu Asp Glu Glu Glu Leu Asn His Arg Leu Val Val Leu 
    50                  55                  60                  


Gly Lys Leu Asn Asn Leu Val Lys Glu Trp Ile Ser Asp Val Ser Glu 
65                  70                  75                  80  


Ser Lys Asn Leu Pro Pro Ser Val Val Ala Thr Val Gly Gly Lys Ile 
                85                  90                  95      


Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp 
            100                 105                 110         


Ile Asp Ala Leu Cys Val Ala Pro Arg His Val Glu Arg Ser Asp Phe 
        115                 120                 125             


Phe Gln Ser Phe Phe Glu Lys Leu Lys His Gln Asp Gly Ile Arg Asn 
    130                 135                 140                 


Leu Arg Ala Val Glu Asp Ala Phe Val Pro Val Ile Lys Phe Glu Phe 
145                 150                 155                 160 


Asp Gly Ile Glu Ile Asp Leu Val Phe Ala Arg Leu Ala Ile Gln Thr 
                165                 170                 175     


Ile Ser Asp Asn Leu Asp Leu Arg Asp Asp Ser Arg Leu Arg Ser Leu 
            180                 185                 190         


Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu 
        195                 200                 205             


Ile Leu His Leu Val Pro Asn Lys Glu Thr Phe Arg Leu Thr Leu Arg 
    210                 215                 220                 


Ala Val Lys Leu Trp Ala Lys Arg Arg Gly Ile Tyr Ser Asn Met Leu 
225                 230                 235                 240 


Gly Phe Leu Gly Gly Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys 
                245                 250                 255     


Gln Leu Tyr Pro Asn Ala Ala Ala Ser Thr Leu Val His Lys Phe Phe 
            260                 265                 270         


Leu Val Phe Ser Lys Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln 
        275                 280                 285             


Pro Glu Glu Ser Asn Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn 
    290                 295                 300                 


Pro Ser Asp Arg Tyr His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro 
305                 310                 315                 320 


Gln Gln Asn Ser Thr Tyr Asn Val Ser Thr Ser Thr Arg Thr Val Met 
                325                 330                 335     


Val Glu Glu Phe Lys Gln Gly Leu Ala Val Thr Asp Glu Ile Leu Gln 
            340                 345                 350         


Gly Lys Ser Asp Trp Ser Lys Leu Leu Glu Pro Pro Asn Phe Phe Gln 
        355                 360                 365             


Lys Tyr Arg His Tyr Ile Val Leu Thr Ala Ser Ala Ser Thr Glu Glu 
    370                 375                 380                 


Asn His Leu Glu Trp Val Gly Leu Val Glu Ser Lys Ile Arg Val Leu 
385                 390                 395                 400 


Val Gly Asn Leu Glu Arg Asn Glu Phe Ile Thr Leu Ala His Val Asn 
                405                 410                 415     


Pro Gln Ser Phe Pro Gly Asn Lys Glu His His Lys Asp Asn Asn Tyr 
            420                 425                 430         


Val Ser Met Trp Phe Leu Gly Ile Ile Phe Arg Arg Val Glu Asn Ala 
        435                 440                 445             


Glu Ser Val Asn Ile Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp 
    450                 455                 460                 


Thr Val Tyr Arg Gln Ala Asn Asn Ile Asn Met Leu Lys Glu Gly Met 
465                 470                 475                 480 


Lys Ile Glu Ala Thr His Val Lys Lys Lys Gln Leu His His Tyr Leu 
                485                 490                 495     


Pro Ala Glu Ile Leu Gln Lys Lys Lys Lys Gln Ser Leu Ser Asp Val 
            500                 505                 510         


Asn Arg Ser Ser Gly Gly Leu Gln Ser Lys Arg Leu Ser Leu Asp Ser 
        515                 520                 525             


Ser Cys Leu Asp Ser Ser Arg Asp Thr Asp Asn Gly Thr Pro Phe Asn 
    530                 535                 540                 


Ser Pro Ala Ser Lys Ser Asp Ser Pro Ser Val Gly Glu Thr Glu Arg 
545                 550                 555                 560 


Asn Ser Ala Glu Pro Ala Ala Val Ile Val Glu Lys Pro Leu Ser Val 
                565                 570                 575     


Pro Pro Ala Gln Gly Leu Ser Ile Pro Val Ile Gly Ala Lys Val Asp 
            580                 585                 590         


Ser Thr Val Lys Thr Val Ser Pro Pro Thr Val Cys Thr Ile Pro Thr 
        595                 600                 605             


Val Val Gly Arg Asn Val Ile Pro Arg Ile Thr Thr Pro His Asn Pro 
    610                 615                 620                 


Ala Gln Gly Gln Pro His Leu Asn Gly Met Ser Asn Ile Thr Lys Thr 
625                 630                 635                 640 


Val Thr Pro Lys Arg Ser His Ser Pro Ser Ile Asp Gly Thr Pro Lys 
                645                 650                 655     


Arg Leu Lys Asp Val Glu Lys Phe Ile Arg Leu Glu Ser Thr Phe Lys 
            660                 665                 670         


Asp Pro Arg Thr Ala Glu Glu Arg Lys Arg Lys Ser Val Asp Ala Ile 
        675                 680                 685             


Gly Gly Glu Ser Met Pro Ile Pro Thr Ile Asp Thr Ser Arg Lys Lys 
    690                 695                 700                 


Arg Leu Pro Ser Lys Glu Leu Pro Asp Ser Ser Ser Pro Val Pro Ala 
705                 710                 715                 720 


Asn Asn Ile Arg Val Ile Lys Asn Ser Ile Arg Leu Thr Leu Asn Arg 
                725                 730                 735     






<210>  2863
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Neo-PAP__Homo_sapiens__AAI11702

<400>  2863
augaaagaga ugucugcaaa caccgugcug gacagccagc gucaacaaaa gcauuaugga       60

auuaccuccc caauuaguuu ggcaucuccu aaagaaauug aucauauuua cacacagaaa      120

uuaauugacg ccaugaaacc auuuggagug uuugaagaug aggaagaauu gaaccacagg      180

cuggugguuc uugguaaauu gaacaauuua guaaaagaau ggauuucuga ugucagcgag      240

aguaagaacc ucccaccuuc uguuguggcu acuguuggug guaaaauuuu cacauuugga      300

uccuauaggc uuggaguaca caccaaagga gcugacauug augcacuuug uguagcucca      360

agacaugugg aaagaucuga uuuuuuucag ucuuuuuuug aaaaauugaa acaucaagau      420

ggcauuagaa acuuaagagc uguagaagau gccuuuguac cuguuauaaa auuugaauuu      480

gaugguauug aaauugaucu agucuuugca agacuggcaa uacaaaccau aucagauaau      540

uuagaucuaa gagacgacuc ucgccugaga agccuugaua uaagguguau ucgcagcuua      600

aaugguugua gaguuacuga ugaaauuuug cauuuagugc caaauaaaga aacuuuuaga      660

cucacccuaa gagcugucaa auuaugggca aaacgacgug guauuuauuc caacaugcua      720

ggauuccuug guggugucuc cugggcaaug cuaguugcaa gaacuugcca auuguaucca      780

aaugcagcag caucuacuuu aguucauaag uucuuuuuag uuuuuuccaa gugggaaugg      840

ccaaauccug ugcugcugaa gcaaccagaa gaaagcaauu ugaauuugcc ugucugggau      900

ccucggguaa auccaucaga uagguaucau cucaugccca uaaucacccc ugccuaccca      960

caacagaauu cuacguauaa uguguccaca ucaacucgaa caguaauggu agaagaauuu     1020

aaacaagguc uugcagucac agaugaaauu cuucaaggaa agucagauug guccaaacua     1080

cuugagccac cgaauuucuu ucaaaaguau agacauuaua uaguauugac ugccagcgca     1140

ucaacagaag aaaaccaucu agaguggguu ggauuaguag aaucuaaaau ccguguacuu     1200

guuggaaacu uggaacggaa ugaauuuauu acucuugccc augugaaucc ccagucauuc     1260

ccagggaaua aggaacauca uaaagacaac aauuacguau caaugugguu ccuugggaua     1320

auuuuucgga gaguagaaaa ugcagaaagu gucaacauag acuugacaua ugauauacag     1380

ucauuuacug auacagugua cagacaggca aacaauauaa auaugcuaaa ggagggaaug     1440

aaaauugaag caacucaugu aaagaaaaaa caacuucacc acuaccuucc ugcagaaauu     1500

cuucaaaaga agaaaaagca aagucucucu gaugucaauc gaagcucggg cggacuucaa     1560

uccaaaagau ugucucugga uagcaguugu cuggauagcu ccagagacac ugauaaugga     1620

acaccuuuua auucuccagc guccaagucu gauagcccuu cuguaggaga aacagaaagg     1680

aauagugcug agccugcugc uguaauugug gagaagccac ugaguguacc accagcccaa     1740

ggacuuucca uuccagugau uggcgcaaaa guugacucua caguaaaaac uguaucaccc     1800

cccacugugu guaccauucc uaccguagua ggacgaaaug ucauuccuag aaucacaaca     1860

ccucacaacc cugcccaggg acaaccgcau cugaauggaa ugucaaauau aacuaagacu     1920

guuacaccua agagauccca uuccccaucc auagauggga cuccuaagag guugaaagac     1980

guagaaaagu uuauucgacu ugaaucaaca uuuaaggacc cccgcacugc ugaagaaaga     2040

aaaagaaaau caguggaugc cauuggagga gaaucuaugc cuauuccaac uauugauaca     2100

ucacgcaaaa agagacuacc caguaaagaa cuaccagauu caucaucucc aguuccagca     2160

aacaacaucc gugucaucaa aaauuccauu cgacugaccc uuaaucggua a              2211


<210>  2864
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Neo-PAP__Homo_sapiens__AAI11702

<400>  2864
augaaggaga ugagcgccaa caccgugcug gacucccagc gccagcagaa gcacuacggc       60

aucaccagcc ccaucucccu cgccagcccg aaggagaucg accacaucua cacgcagaag      120

cugaucgacg cgaugaagcc cuucgggguc uucgaggacg aggaggagcu gaaccaccgg      180

cucguggugc ugggcaagcu gaacaaccuc gucaaggagu ggaucuccga cgugagcgag      240

uccaagaacc ugccgcccag cguggucgcc accgucgggg gcaagaucuu caccuucggg      300

uccuaccgcc ugggcgugca caccaagggc gccgacaucg acgcccucug cgucgccccg      360

cggcacgugg agcgcagcga cuucuuccag uccuucuucg agaagcugaa gcaccaggac      420

gggauccgga accugcgcgc gguggaggac gccuucgucc ccgugaucaa guucgaguuc      480

gacggcaucg agaucgaccu cguguucgcc cggcuggcca uccagacgau cagcgacaac      540

cuggaccucc gcgacgacuc ccggcugcgc agccuggaca uccggugcau ccgcucccuc      600

aacgggugcc gggucaccga cgagauccug caccuggugc ccaacaagga gaccuuccgc      660

cucacccugc gggcggugaa gcugugggcc aagcgccggg gcaucuacag caacaugcuc      720

ggguuccugg gcggcgucuc cugggccaug cugguggccc gcacgugcca gcucuacccc      780

aacgccgcgg ccagcacccu ggugcacaag uucuuccugg ucuucuccaa gugggagugg      840

ccgaaccccg ugcuccugaa gcagcccgag gagagcaacc ugaaccuccc cgugugggac      900

ccgcggguca accccagcga ccgcuaccac cugaugccca ucaucacccc cgccuacccg      960

cagcagaacu ccaccuacaa cgugagcacg uccacccgga ccgucauggu ggaggaguuc     1020

aagcaggggc uggccgugac cgacgagauc cuccagggca agagcgacug guccaagcug     1080

cuggagccgc ccaacuucuu ccagaaguac cgccacuaca ucguccucac ggccagcgcg     1140

uccaccgagg agaaccaccu ggagugggug gggcuggugg agagcaagau ccgcguccuc     1200

gugggcaacc uggagcggaa cgaguucauc acccuggccc acgugaaccc ccaguccuuc     1260

cccggcaaca aggagcacca caaggacaac aacuacguca gcaugugguu ccucgggauc     1320

aucuuccgcc ggguggagaa cgccgagucc gugaacaucg accugaccua cgacauccag     1380

agcuucacgg acaccgucua ccgccaggcc aacaacauca acaugcugaa ggagggcaug     1440

aagaucgagg ccacccacgu gaagaagaag cagcuccacc acuaccugcc cgcggagauc     1500

cugcagaaga agaagaagca gucccugagc gacgugaacc gguccagcgg gggccuccag     1560

uccaagcgcc ugagccugga cuccagcugc cucgacagcu cccgggacac cgacaacggg     1620

acgcccuuca acagccccgc cuccaagagc gacuccccga gcgucggcga gaccgagcgc     1680

aacuccgccg agcccgccgc cgugaucgug gagaagcccc ugagcgugcc cccggcgcag     1740

ggccugucca uccccgugau cggggccaag guggacagca ccgucaagac cguguccccg     1800

cccacggugu gcaccauccc caccgucgug ggccggaacg ugaucccccg caucaccacg     1860

ccccacaacc ccgcccaggg gcagccccac cucaacggca ugagcaacau caccaagacc     1920

gucaccccca agcgguccca cagccccucc aucgacggga cgccgaagcg ccugaaggac     1980

guggagaagu ucauccggcu ggagagcacc uucaaggacc cccgcaccgc cgaggagcgg     2040

aagcgcaagu ccguggacgc gaucggcggc gagagcaugc ccauccccac caucgacacc     2100

agccggaaga agcgccuccc guccaaggag cugcccgaca gcuccagccc cguccccgcc     2160

aacaacaucc gggugaucaa gaacuccauc cgccugacgc ucaaccgcug a              2211


<210>  2865
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Neo-PAP__Homo_sapiens__AAI11702

<400>  2865
augaaggaga uguccgccaa caccguccuc gacucccagc gccagcagaa gcacuacggc       60

aucaccuccc ccaucucccu cgccuccccc aaggagaucg accacaucua cacccagaag      120

cucaucgacg ccaugaagcc cuucggcguc uucgaggacg aggaggagcu caaccaccgc      180

cucgucgucc ucggcaagcu caacaaccuc gucaaggagu ggaucuccga cgucuccgag      240

uccaagaacc ucccccccuc cgucgucgcc accgucggcg gcaagaucuu caccuucggc      300

uccuaccgcc ucggcgucca caccaagggc gccgacaucg acgcccucug cgucgccccc      360

cgccacgucg agcgcuccga cuucuuccag uccuucuucg agaagcucaa gcaccaggac      420

ggcauccgca accuccgcgc cgucgaggac gccuucgucc ccgucaucaa guucgaguuc      480

gacggcaucg agaucgaccu cgucuucgcc cgccucgcca uccagaccau cuccgacaac      540

cucgaccucc gcgacgacuc ccgccuccgc ucccucgaca uccgcugcau ccgcucccuc      600

aacggcugcc gcgucaccga cgagauccuc caccucgucc ccaacaagga gaccuuccgc      660

cucacccucc gcgccgucaa gcucugggcc aagcgccgcg gcaucuacuc caacaugcuc      720

ggcuuccucg gcggcgucuc cugggccaug cucgucgccc gcaccugcca gcucuacccc      780

aacgccgccg ccuccacccu cguccacaag uucuuccucg ucuucuccaa gugggagugg      840

cccaaccccg uccuccucaa gcagcccgag gaguccaacc ucaaccuccc cgucugggac      900

ccccgcguca accccuccga ccgcuaccac cucaugccca ucaucacccc cgccuacccc      960

cagcagaacu ccaccuacaa cgucuccacc uccacccgca ccgucauggu cgaggaguuc     1020

aagcagggcc ucgccgucac cgacgagauc cuccagggca aguccgacug guccaagcuc     1080

cucgagcccc ccaacuucuu ccagaaguac cgccacuaca ucguccucac cgccuccgcc     1140

uccaccgagg agaaccaccu cgaguggguc ggccucgucg aguccaagau ccgcguccuc     1200

gucggcaacc ucgagcgcaa cgaguucauc acccucgccc acgucaaccc ccaguccuuc     1260

cccggcaaca aggagcacca caaggacaac aacuacgucu ccaugugguu ccucggcauc     1320

aucuuccgcc gcgucgagaa cgccgagucc gucaacaucg accucaccua cgacauccag     1380

uccuucaccg acaccgucua ccgccaggcc aacaacauca acaugcucaa ggagggcaug     1440

aagaucgagg ccacccacgu caagaagaag cagcuccacc acuaccuccc cgccgagauc     1500

cuccagaaga agaagaagca gucccucucc gacgucaacc gcuccuccgg cggccuccag     1560

uccaagcgcc ucucccucga cuccuccugc cucgacuccu cccgcgacac cgacaacggc     1620

acccccuuca acucccccgc cuccaagucc gacucccccu ccgucggcga gaccgagcgc     1680

aacuccgccg agcccgccgc cgucaucguc gagaagcccc ucuccguccc ccccgcccag     1740

ggccucucca uccccgucau cggcgccaag gucgacucca ccgucaagac cgucuccccc     1800

cccaccgucu gcaccauccc caccgucguc ggccgcaacg ucaucccccg caucaccacc     1860

ccccacaacc ccgcccaggg ccagccccac cucaacggca uguccaacau caccaagacc     1920

gucaccccca agcgcuccca cucccccucc aucgacggca cccccaagcg ccucaaggac     1980

gucgagaagu ucauccgccu cgaguccacc uucaaggacc cccgcaccgc cgaggagcgc     2040

aagcgcaagu ccgucgacgc caucggcggc gaguccaugc ccauccccac caucgacacc     2100

ucccgcaaga agcgccuccc cuccaaggag cuccccgacu ccuccucccc cguccccgcc     2160

aacaacaucc gcgucaucaa gaacuccauc cgccucaccc ucaaccgcug a              2211


<210>  2866
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Neo-PAP__Homo_sapiens__AAI11702

<400>  2866
augaaggaga ugagcgccaa caccgugcug gacucccaga gacaacagaa acacuacggc       60

aucacaucuc ccauuucacu cgcuaguccu aaggaaauag aucauaucua uacucagaaa      120

cuuauugacg caaugaagcc auucgggguc uuugaggaug aagaggaacu gaaucacagg      180

uugguugugu uaggaaaacu gaacaaucua guaaaggagu ggaucagcga cguguccgag      240

ucuaagaacc ucccgcccuc ggucguggcc acgguuggug gcaaaauuuu caccuuuggg      300

ucauaccggc ugggagugca uacaaagggc gcggauaucg acgcucuuug cgucgccccu      360

cgccacgugg aacgaagcga uuucuuucag aguuucuuug agaaacugaa gcaucaagac      420

gguauacgua auuugagagc aguagaagau gccuucguuc cagugaucaa auuugaguuc      480

gacgggauug agaucgaucu cgucuuugcu aggcuggcaa uucagacuau cuccgacaac      540

cuggaucucc gggacgacuc ucgcuuaaga agccuggaua uaagguguau ucggucccuu      600

aauggaugcc gcgugaccga cgaaaucuug caccuggugc ccaacaagga gacauuccga      660

cuaacccuca gagccgucaa gcugugggcu aaaaggcggg gcauuuauuc aaauaugcuu      720

ggcuuucugg gagggguuag uugggccaug uugguggcgc guacuuguca gcucuacccu      780

aacgcagccg cuagcacacu gguacacaag uucuucuuag uguuuucuaa augggaaugg      840

ccaaaucccg uccugcucaa gcagccugag gaauccaacc uuaaucugcc agugugggau      900

ccgcgcguua accccucaga cagauaucau uugaugccua ucaucacccc agccuacccc      960

caacagaaua gcacguauaa cgugaguacu ucuaccagga cagucauggu ggaggaguuc     1020

aaacaggguc uagcaguaac ugaugaaauu cugcagggca aguccgacug gagcaaacuc     1080

cuggagccuc caaacuuuuu ccaaaaguac cggcacuaca uaguucuuac cgcuucggcc     1140

ucuacagaag agaaucaucu ggaaugggug ggguuggucg aguccaagau ccgagugcuc     1200

gucggaaacc uggagcgcaa ugaauuuauu accuuagcgc acgugaaccc ccagucauuc     1260

ccgggcaaua aagagcacca uaaggauaac aauuauguua guaugugguu ucuggguauc     1320

auauucagaa ggguggaaaa cgccgagagc guaaauauug accuaacgua cgauauccag     1380

uccuuuacug acacagucua ucggcaagca aacaauauca acaugcucaa agaagggaug     1440

aagauugagg cuacccacgu gaaaaagaag cagcugcauc acuaccuucc ugccgagauc     1500

uugcagaaaa agaaaaagca gucucugagc gauguuaauc gcucaagugg aggccuccaa     1560

uccaaaagac ugagccuuga cucuucaugc cuggacagua gcagggauac ugacaacggc     1620

acacccuuca auuccccagc uucuaagucg gauagcccuu ccguggggga aaccgagcgu     1680

aacucagccg aacccgcagc cgucauugug gagaagccau ugaguguacc cccugcucag     1740

ggacucucua uaccagugau cggugcgaaa guugacagca cggucaagac cguguccccg     1800

cccacagugu guacuauucc uaccgucguu ggccggaacg ugaucccacg aaucacaacu     1860

ccccauaauc cugcacaggg gcagccacac cugaacggaa ugucaaauau uaccaaaaca     1920

gugaccccca agagaagcca cucuccgucc auagauggca cuccuaaaag guuaaaggac     1980

guagagaagu uuauccgccu ggaaaguacg uucaaagauc cacggacagc cgaggaaaga     2040

aagaggaaaa gcgucgacgc uauugguggg gagucuaugc ccaucccuac cauugauacu     2100

ucccgcaaga aacgacuacc cucaaaggaa cucccagaca guagcucgcc ugugcccgcc     2160

aacaauaucc ggguuaucaa aaacuccaua cgucugaccc uuaauagaug a              2211


<210>  2867
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Neo-PAP__Homo_sapiens__AAI11702

<400>  2867
augaaggaga ugagcgccaa caccgugcug gacagccaga gacagcagaa gcacuacggc       60

aucaccagcc ccaucagccu ggccagcccc aaggagaucg accacaucua cacccagaag      120

cugaucgacg ccaugaagcc cuucggcgug uucgaggacg aggaggagcu gaaccacaga      180

cugguggugc ugggcaagcu gaacaaccug gugaaggagu ggaucagcga cgugagcgag      240

agcaagaacc ugccccccag cgugguggcc accgugggcg gcaagaucuu caccuucggc      300

agcuacagac ugggcgugca caccaagggc gccgacaucg acgcccugug cguggccccc      360

agacacgugg agagaagcga cuucuuccag agcuucuucg agaagcugaa gcaccaggac      420

ggcaucagaa accugagagc cguggaggac gccuucgugc ccgugaucaa guucgaguuc      480

gacggcaucg agaucgaccu gguguucgcc agacuggcca uccagaccau cagcgacaac      540

cuggaccuga gagacgacag cagacugaga agccuggaca ucagaugcau cagaagccug      600

aacggcugca gagugaccga cgagauccug caccuggugc ccaacaagga gaccuucaga      660

cugacccuga gagccgugaa gcugugggcc aagagaagag gcaucuacag caacaugcug      720

ggcuuccugg gcggcgugag cugggccaug cugguggcca gaaccugcca gcuguacccc      780

aacgccgccg ccagcacccu ggugcacaag uucuuccugg uguucagcaa gugggagugg      840

cccaaccccg ugcugcugaa gcagcccgag gagagcaacc ugaaccugcc cgugugggac      900

cccagaguga accccagcga cagauaccac cugaugccca ucaucacccc cgccuacccc      960

cagcagaaca gcaccuacaa cgugagcacc agcaccagaa ccgugauggu ggaggaguuc     1020

aagcagggcc uggccgugac cgacgagauc cugcagggca agagcgacug gagcaagcug     1080

cuggagcccc ccaacuucuu ccagaaguac agacacuaca ucgugcugac cgccagcgcc     1140

agcaccgagg agaaccaccu ggagugggug ggccuggugg agagcaagau cagagugcug     1200

gugggcaacc uggagagaaa cgaguucauc acccuggccc acgugaaccc ccagagcuuc     1260

cccggcaaca aggagcacca caaggacaac aacuacguga gcaugugguu ccugggcauc     1320

aucuucagaa gaguggagaa cgccgagagc gugaacaucg accugaccua cgacauccag     1380

agcuucaccg acaccgugua cagacaggcc aacaacauca acaugcugaa ggagggcaug     1440

aagaucgagg ccacccacgu gaagaagaag cagcugcacc acuaccugcc cgccgagauc     1500

cugcagaaga agaagaagca gagccugagc gacgugaaca gaagcagcgg cggccugcag     1560

agcaagagac ugagccugga cagcagcugc cuggacagca gcagagacac cgacaacggc     1620

acccccuuca acagccccgc cagcaagagc gacagcccca gcgugggcga gaccgagaga     1680

aacagcgccg agcccgccgc cgugaucgug gagaagcccc ugagcgugcc ccccgcccag     1740

ggccugagca uccccgugau cggcgccaag guggacagca ccgugaagac cgugagcccc     1800

cccaccgugu gcaccauccc caccguggug ggcagaaacg ugauccccag aaucaccacc     1860

ccccacaacc ccgcccaggg ccagccccac cugaacggca ugagcaacau caccaagacc     1920

gugaccccca agagaagcca cagccccagc aucgacggca cccccaagag acugaaggac     1980

guggagaagu ucaucagacu ggagagcacc uucaaggacc ccagaaccgc cgaggagaga     2040

aagagaaaga gcguggacgc caucggcggc gagagcaugc ccauccccac caucgacacc     2100

agcagaaaga agagacugcc cagcaaggag cugcccgaca gcagcagccc cgugcccgcc     2160

aacaacauca gagugaucaa gaacagcauc agacugaccc ugaacagaug a              2211


<210>  2868
<211>  2211
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Neo-PAP__Homo_sapiens__AAI11702

<400>  2868
augaaggaga ugagcgccaa caccgugcug gacucccaga gacaacagaa acacuacggc       60

aucacaucuc ccauuagccu cgcuuccccu aaggaaaucg aucauauuua uacgcagaaa      120

cugaucgacg ccaugaagcc guucgggguc uuugaggaug aagaggaacu uaaucaccgg      180

cugguugugc ucggaaaacu gaacaaucuu gugaaggagu ggauuucuga cgucagcgag      240

uccaagaacc ugcccccuuc ugugguugcg accgugggcg ggaaaaucuu cacauuugga      300

agcuaccgcc ucggcgucca uaccaagggg gcugauaucg acgcccugug cguggccccc      360

agacacguug aacgguccga uuucuuucag agcuucuuug agaaacugaa gcaucaagac      420

ggcauucgca aucucagagc uguggaagau gccuucgucc cugugaucaa auuugaguuc      480

gacggaauug agaucgaucu gguguuugcu cggcuugcca uucagacaau cucugacaac      540

cuggaucucc gcgacgacuc cagacugcgg agccuugaua uucgcuguau cagaucucug      600

aauggcugcc gggucaccga cgaaauccuc caccugguuc ccaacaagga gacauuccgc      660

cugacccuca gagcggugaa gcugugggcc aaacggcgcg ggauuuauuc caauaugcuu      720

ggauuucugg gcggggugag cugggcuaug cucgucgcca gaacguguca gcuguacccu      780

aacgcugccg cgucuacccu ugugcacaag uucuuccugg uguuuuccaa augggaaugg      840

ccgaaucccg uucuccugaa gcagccugag gaaagcaacc ugaaucuccc cgucugggau      900

ccucggguga accccuccga cagauaucau cugaugccga ucauuacccc ugccuacccc      960

caacaaaauu cuacauauaa cguuagcaca uccacccgca cggugauggu cgaggaguuc     1020

aaacagggac uugcugugac agaugaaauc cugcagggca agagcgacug gucuaaacuc     1080

cuggagccuc ccaacuuuuu ccagaaguac cggcacuaca uuguccuuac cgccuccgcu     1140

agcacagaag agaaucaucu ggaaugggug gggcucguug agucuaagau cagagugcug     1200

gucggaaacc uggagcgcaa ugaauuuauc acccucgccc acgugaaccc ccagagcuuc     1260

ccuggcaaua aagagcacca uaaggauaac aauuauguuu ccaugugguu ucugggcauu     1320

aucuuccgga gaguggaaaa cgccgagucu gucaauauug accuuaccua cgauauccag     1380

agcuuuacag acacggugua ucgccaagcu aacaauauua acaugcugaa agaagggaug     1440

aagaucgagg cgacccacgu gaaaaagaag cagcuccauc acuaccugcc ggccgagauc     1500

cugcagaaaa agaaaaagca gucccuuagc gauguuaauc ggucuuccgg aggccuccaa     1560

agcaaaagac ugucucugga cuccagcugc cucgacuccu cucgcgauac agacaacggg     1620

acccccuuca auagcccugc uuccaagucu gauagccccu ccgucggaga aacagagcgg     1680

aacagcgccg aaccugccgc ugugauugug gagaagcccc ugucuguccc gccugcccag     1740

ggccuuucca uccccgugau uggggcgaaa guugacagca ccgugaagac ggucucuccu     1800

cccacagugu guaccauccc uaccguugug ggaagaaacg ucauuccccg caucacaacc     1860

ccgcauaauc cugcucaggg ccagccccac cugaacggca uguccaauau uacaaaaacg     1920

gugaccccca agcggagcca cucuccuagc aucgauggga caccgaaaag acucaaggac     1980

guugagaagu uuauccggcu ggaauccacc uucaaagauc cccgcacagc cgaggaaaga     2040

aagcggaaaa gcguggacgc cauuggaggc gagucuaugc cuauccccac cauugauacg     2100

uccagaaaga aacgccugcc uagcaaggaa cuucccgacu ccucuagccc uguccccgcu     2160

aacaauaucc gggugauuaa aaacuccauc agacucaccc ugaaucgcug a              2211


<210>  2869
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NFYC/m__Homo_sapiens__Q13952

<400>  2869

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Gly Gln Arg Asn Ala Ser Gln Gly Lys Pro Arg Arg 
        275                 280                 285             


Cys Leu Lys Glu Thr Leu Gln Ile Thr Gln Thr Glu Val Gln Gln Gly 
    290                 295                 300                 


Gln Gln Gln Phe Ser Gln Phe Thr Asp Gly Gln Arg Asn Ser Val Gln 
305                 310                 315                 320 


Gln Ala Arg Val Ser Glu Leu Thr Gly Glu Ala Glu Pro Arg Glu Val 
                325                 330                 335     


Lys Ala Thr Gly Asn Ser Thr Pro Cys Thr Ser Ser Leu Pro Thr Thr 
            340                 345                 350         


His Pro Pro Ser His Arg Ala Gly Ala Ser Cys Val Cys Cys Ser Gln 
        355                 360                 365             


Pro Gln Gln Ser Ser Thr Ser Pro Pro Pro Ser Asp Ala Leu Gln Trp 
    370                 375                 380                 


Val Val Val Glu Val Ser Gly Thr Pro Asn Gln Leu Glu Thr His Arg 
385                 390                 395                 400 


Glu Leu His Ala Pro Leu Pro Gly Met Thr Ser Leu Ser Pro Leu His 
                405                 410                 415     


Pro Ser Gln Gln Leu Tyr Gln Ile Gln Gln Val Thr Met Pro Ala Gly 
            420                 425                 430         


Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala Asn Gln Pro Ser 
        435                 440                 445             


Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
    450                 455             


<210>  2870
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NFYC/m__Homo_sapiens__AAG28389

<400>  2870
auguccacag aaggaggauu uggugguacu agcagcagug augcccagca aagucuacag       60

ucguucuggc cucgggucau ggaagaaauc cggaauuuaa cagugaaaga cuuccgagug      120

caggaacucc cacuggcucg uauuaagaag auuaugaaac uggaugaaga ugugaagaug      180

aucagugcag aagcgccugu acucuuugcc aaggcagccc agauuuuuau cacagaguug      240

acucuucgag ccuggauuca cacagaagau aacaagcgcc ggacucuaca gagaaaugau      300

aucgccaugg caauuacaaa auuugaucag uuugauuuuc ucaucgauau uguuccaaga      360

gaugaacuga aaccuccaaa gcgucaggag gaggugcgcc agucuguaac uccugccgag      420

ccaguccagu acuauuucac gcuggcucag caacccaccg cuguccaagu ccagggccag      480

cagcaaggcc agcagaccac cagcuccacg accaccaucc agccugggca gaucaucauc      540

gcacagccuc agcagggcca gaccacaccu gugacaaugc agguuggaga aggucagcag      600

gugcagauug uccaggcuca gccacagggu caagcccaac aggcccagag uggcacugga      660

cagaccaugc aggugaugca gcagaucauc acuaacacag gagagaucca gcagaucccg      720

gugcagcuga augccggcca gcugcaguau auccgcuuag cccagccugu aucaggcacu      780

caaguugugc agggacagau ccagacacuu gccaccaaug cucaacaggg gcaaagaaau      840

gcaagucagg ggaagccucg aaggugccug aaagaaaccu uacagauuac acagacagag      900

guccagcaag gacagcagca guucagccag uucacagaug gacagaggaa cagcgugcag      960

caagcucgag ucucugagcu aacgggagag gcagagccca gagaagugaa agccacagga     1020

aauucaacuc ccugcaccuc uucccugccc accacacacc cccccucaca ccgggcuggu     1080

gccuccugug ucugcugcuc ccaaccccag cagagcucca cuuccccucc uccuucugac     1140

gccuugcagu gggugguggu ugagguaucu gggaccccca accagcucga gacccauagg     1200

gagcugcaug ccccucuccc agggaugacc ucacucucuc cucuccaccc cucgcagcag     1260

cucuaccaga uccagcaagu caccaugccu gcgggccagg accucgccca gcccauguuc     1320

auccagucag ccaaccagcc cuccgacggg caggcccccc aggugaccgg cgacuga        1377


<210>  2871
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NFYC/m__Homo_sapiens__AAG28389

<400>  2871
augagcaccg agggcggguu cggcgggacc uccagcuccg acgcccagca gagccugcag       60

uccuucuggc cccgcgugau ggaggagauc cggaaccuca cggucaagga cuuccgcgug      120

caggagcugc cgcuggcccg gaucaagaag aucaugaagc ucgacgagga cgugaagaug      180

aucagcgccg aggcccccgu ccuguucgcc aaggccgccc agaucuucau caccgagcug      240

acccuccgcg cguggaucca caccgaggac aacaagcggc gcacgcugca gcggaacgac      300

aucgccaugg ccaucaccaa guucgaccag uucgacuucc ugaucgacau cgugccccgc      360

gacgagcuca agcccccgaa gcggcaggag gaggugcgcc aguccgucac ccccgccgag      420

cccgugcagu acuacuucac ccuggcgcag cagcccacgg ccgugcaggu ccagggccag      480

cagcaggggc agcagaccac cagcuccacc acgaccaucc agccgggcca gaucaucauc      540

gcccagcccc agcagggcca gaccaccccc gugacgaugc aggucgggga gggccagcag      600

guccagaucg ugcaggccca gccccagggg caggcccagc aggcgcagag cggcaccggg      660

cagaccaugc aggucaugca gcagaucauc accaacacgg gcgagaucca gcagaucccg      720

gugcagcuga acgccggcca gcuccaguac auccggcugg cccagcccgu guccgggacc      780

cagguggugc agggccagau ccagacccug gccaccaacg cccagcaggg gcagcgcaac      840

gcgagccagg gcaagccccg gcgcugccuc aaggagacgc ugcagaucac ccagaccgag      900

gugcagcagg gccagcagca guucucccag uucaccgacg ggcagcggaa cagcgugcag      960

caggcccgcg ucuccgagcu gacgggcgag gccgagcccc gggaggugaa ggccaccggg     1020

aacagcaccc cgugcaccuc cagccucccc acgacccacc cgcccuccca ccgcgccggc     1080

gcgagcugcg ugugcugcag ccagccccag caguccagca ccuccccgcc gcccagcgac     1140

gcccugcagu gggucguggu cgaggugucc gggaccccca accagcugga gacgcaccgg     1200

gagcuccacg cgccccugcc cggcaugacc agccugagcc cccuccaccc cucccagcag     1260

cuguaccaga uccagcaggu caccaugccc gccggccagg accuggccca gcccauguuc     1320

auccaguccg ccaaccagcc gagcgacggg caggcgcccc aggugaccgg cgacuga        1377


<210>  2872
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NFYC/m__Homo_sapiens__AAG28389

<400>  2872
auguccaccg agggcggcuu cggcggcacc uccuccuccg acgcccagca gucccuccag       60

uccuucuggc cccgcgucau ggaggagauc cgcaaccuca ccgucaagga cuuccgcguc      120

caggagcucc cccucgcccg caucaagaag aucaugaagc ucgacgagga cgucaagaug      180

aucuccgccg aggcccccgu ccucuucgcc aaggccgccc agaucuucau caccgagcuc      240

acccuccgcg ccuggaucca caccgaggac aacaagcgcc gcacccucca gcgcaacgac      300

aucgccaugg ccaucaccaa guucgaccag uucgacuucc ucaucgacau cgucccccgc      360

gacgagcuca agccccccaa gcgccaggag gagguccgcc aguccgucac ccccgccgag      420

cccguccagu acuacuucac ccucgcccag cagcccaccg ccguccaggu ccagggccag      480

cagcagggcc agcagaccac cuccuccacc accaccaucc agcccggcca gaucaucauc      540

gcccagcccc agcagggcca gaccaccccc gucaccaugc aggucggcga gggccagcag      600

guccagaucg uccaggccca gccccagggc caggcccagc aggcccaguc cggcaccggc      660

cagaccaugc aggucaugca gcagaucauc accaacaccg gcgagaucca gcagaucccc      720

guccagcuca acgccggcca gcuccaguac auccgccucg cccagcccgu cuccggcacc      780

caggucgucc agggccagau ccagacccuc gccaccaacg cccagcaggg ccagcgcaac      840

gccucccagg gcaagccccg ccgcugccuc aaggagaccc uccagaucac ccagaccgag      900

guccagcagg gccagcagca guucucccag uucaccgacg gccagcgcaa cuccguccag      960

caggcccgcg ucuccgagcu caccggcgag gccgagcccc gcgaggucaa ggccaccggc     1020

aacuccaccc ccugcaccuc cucccucccc accacccacc cccccuccca ccgcgccggc     1080

gccuccugcg ucugcugcuc ccagccccag caguccucca ccuccccccc ccccuccgac     1140

gcccuccagu gggucgucgu cgaggucucc ggcaccccca accagcucga gacccaccgc     1200

gagcuccacg ccccccuccc cggcaugacc ucccucuccc cccuccaccc cucccagcag     1260

cucuaccaga uccagcaggu caccaugccc gccggccagg accucgccca gcccauguuc     1320

auccaguccg ccaaccagcc cuccgacggc caggcccccc aggucaccgg cgacuga        1377


<210>  2873
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NFYC/m__Homo_sapiens__AAG28389

<400>  2873
augagcaccg agggcggguu cggagguaca uccucuucag acgcccagca aagucugcag       60

agcuuuuggc ccagagugau ggaagagauc aggaaccuca cugucaagga uuuccggguu      120

caggaacuuc cucuggcucg cauuaaaaag auaaugaaau uggacgagga ugugaagaug      180

aucuccgcag aagccccagu auuauuugcg aaagcugccc agauuuucau cacggagcug      240

acccuacgag cauggauuca cacagaggac aauaagcgua gaacucucca aaggaacgau      300

aucgccaugg cuauaaccaa guuugaccag uucgauuuuc ugaucgacau ugugccgcgg      360

gaugaacuua aacccccuaa gcgccaggag gaagucagac agucugugac accagcagag      420

cccguucaau acuauuucac ccuggcccag cagccuacug cugugcaggu ccaaggccag      480

cagcaagggc agcagacaac cucgucaacg acuaccaucc agccaggaca aauuaucaua      540

gcccagcccc agcagggcca aacaacuccu gugaccaugc agguagguga ggggcagcag      600

guucaaauug ugcaggcgca gccacaggga caagcacagc aggcccaaag cggcacaggc      660

cagaccaugc aggucaugca gcaaaucauu acgaauacug gggaaaucca gcagaucccg      720

gugcaguuga acgcuggaca acuccaguac auuaggcugg cccagcccgu gagugguaca      780

caggucguuc aaggccagau acagacccug gcaacuaaug cucaacaggg gcagcggaac      840

gccucccagg gaaaaccucg ccgaugccuc aaggagacau uacaaaucac ccagacggaa      900

gugcagcagg gccaacagca guuuucucag uucaccgacg gucaaagaaa uagcguacag      960

caggcgaggg uguccgagcu gacaggggaa gccgagccac gggaggucaa agcaacugga     1020

aacucaaccc ccuguacaag uagccuuccu acuacccauc cacccucuca ccgugcuggc     1080

gccuccugcg uguguugcuc acagccgcaa cagagcagua caucuccucc cccauccgau     1140

gcuuugcagu ggguuguggu cgaagugagc ggcaccccua aucaacugga gacucaucgc     1200

gaacuacacg caccccuccc agggaugacg ucgcugucuc cccuucaucc uucccagcag     1260

cuguaucaga uucaacaggu aacaaugcca gccggacagg acuuggccca gccgauguuu     1320

auccaaucag cuaaccagcc cagugauggu caggcgccuc agguuaccgg cgacuga        1377


<210>  2874
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NFYC/m__Homo_sapiens__AAG28389

<400>  2874
augagcaccg agggcggcuu cggcggcacc agcagcagcg acgcccagca gagccugcag       60

agcuucuggc ccagagugau ggaggagauc agaaaccuga ccgugaagga cuucagagug      120

caggagcugc cccuggccag aaucaagaag aucaugaagc uggacgagga cgugaagaug      180

aucagcgccg aggcccccgu gcuguucgcc aaggccgccc agaucuucau caccgagcug      240

acccugagag ccuggaucca caccgaggac aacaagagaa gaacccugca gagaaacgac      300

aucgccaugg ccaucaccaa guucgaccag uucgacuucc ugaucgacau cgugcccaga      360

gacgagcuga agccccccaa gagacaggag gaggugagac agagcgugac ccccgccgag      420

cccgugcagu acuacuucac ccuggcccag cagcccaccg ccgugcaggu gcagggccag      480

cagcagggcc agcagaccac cagcagcacc accaccaucc agcccggcca gaucaucauc      540

gcccagcccc agcagggcca gaccaccccc gugaccaugc aggugggcga gggccagcag      600

gugcagaucg ugcaggccca gccccagggc caggcccagc aggcccagag cggcaccggc      660

cagaccaugc aggugaugca gcagaucauc accaacaccg gcgagaucca gcagaucccc      720

gugcagcuga acgccggcca gcugcaguac aucagacugg cccagcccgu gagcggcacc      780

cagguggugc agggccagau ccagacccug gccaccaacg cccagcaggg ccagagaaac      840

gccagccagg gcaagcccag aagaugccug aaggagaccc ugcagaucac ccagaccgag      900

gugcagcagg gccagcagca guucagccag uucaccgacg gccagagaaa cagcgugcag      960

caggccagag ugagcgagcu gaccggcgag gccgagccca gagaggugaa ggccaccggc     1020

aacagcaccc ccugcaccag cagccugccc accacccacc cccccagcca cagagccggc     1080

gccagcugcg ugugcugcag ccagccccag cagagcagca ccagcccccc ccccagcgac     1140

gcccugcagu gggugguggu ggaggugagc ggcaccccca accagcugga gacccacaga     1200

gagcugcacg ccccccugcc cggcaugacc agccugagcc cccugcaccc cagccagcag     1260

cuguaccaga uccagcaggu gaccaugccc gccggccagg accuggccca gcccauguuc     1320

auccagagcg ccaaccagcc cagcgacggc caggcccccc aggugaccgg cgacuga        1377


<210>  2875
<211>  1377
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NFYC/m__Homo_sapiens__AAG28389

<400>  2875
augagcaccg agggcggguu cggaggcaca uccucuagcg acgcccagca aucccugcag       60

ucuuuuuggc ccagagugau ggaagagauc cggaaccuca cggucaagga uuuccgcguu      120

caggaacugc cucuugcuag aauuaaaaag aucaugaaac uggacgagga ugugaagaug      180

auuagcgccg aagcgccggu gcucuuugcu aaagccgccc agaucuucau uaccgagcug      240

acacuucggg cuuggaucca caccgaggac aauaagcgca gaacacugca acggaacgau      300

aucgccaugg cuauuaccaa guuugaccag uucgauuuuc ucaucgacau ugucccccgc      360

gaugaacuga aaccucccaa gagacaggag gaagugcggc aguccguuac gccugccgag      420

cccgugcaau acuauuucac ccuggcgcag cagccuacgg ccguccaggu gcaagggcag      480

cagcaaggac agcagaccac aucuagcacc acaaccaucc agccgggcca aauuaucauu      540

gcucagcccc agcaggggca aacgacaccu guuaccaugc aagugggaga gggccagcag      600

guccagaucg ugcaggccca gccccagggc caagcucagc aggcccaauc cgggacagga      660

cagaccaugc aagugaugca gcagaucauu accaauacag gcgaaaucca gcagauuccu      720

guccagcuca acgcggggca acugcaguac auccgccuug cccagcccgu uagcggaaca      780

cagguggugc aaggccagau ucagacccug gcuacaaaug cccaacaggg gcagagaaac      840

gcuucucagg gaaaaccgcg gcgcugccuc aaggagaccc ugcaaaucac acagaccgaa      900

guccagcagg gccaacagca guuuucccag uucacggacg gccaaagaaa uagcgugcag      960

caggcccggg uuucugagcu uacaggggaa gccgagccuc gcgaggugaa agcuaccgga     1020

aacuccaccc ccuguacaag cucucugccu accacacauc cucccuccca cagagcgggc     1080

gccagcugcg ucuguugcuc ccagccccaa cagucuagca cguccccgcc cccuagcgau     1140

gcucuccagu gggugguugu ggaagucucu gggaccccca aucaacugga gacacaucgg     1200

gaacugcacg ccccucuccc cggaaugacc ucccugagcc cgcuucaucc uucucagcag     1260

cuguaucaga uccaacaggu gacaaugccc gccggccagg accucgcuca gccuauguuu     1320

auucaaagcg ccaaccagcc cuccgauggg caggcgccuc aggucaccgg agacuga        1377


<210>  2876
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NGEP__Homo_sapiens__Q6IWH7

<400>  2876

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Ala Asp Phe 
            100                 105                 110         


Val Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser 
        115                 120                 125             


Ala Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe 
    130                 135                 140                 


Leu Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Gln Asp Val 
145                 150                 155                 160 


Gln Asp Gly Asn Thr Thr Val His Tyr Ala Leu Leu Ser Ala Ser Trp 
                165                 170                 175     


Ala Val Leu Cys Tyr Tyr Ala Glu Asp Leu Arg Leu Lys Leu Pro Leu 
            180                 185                 190         


Gln Glu Leu Pro Asn Gln Ala Ser Asn Trp Ser Ala Gly Leu Leu Ala 
        195                 200                 205             


Trp Leu Gly Ile Pro Asn Val Leu Leu Glu Val Val Pro Asp Val Pro 
    210                 215                 220                 


Pro Glu Tyr Tyr Ser Cys Arg Phe Arg Val Asn Lys Leu Pro Arg Phe 
225                 230                 235                 240 


Leu Gly Ser Asp Asn Gln Asp Thr Phe Phe Thr Ser Thr Lys Arg His 
                245                 250                 255     


Gln Ile Leu Phe Glu Ile Leu Ala Lys Thr Pro Tyr Gly His Glu Lys 
            260                 265                 270         


Lys Asn Leu Leu Gly Ile His Gln Leu Leu Ala Glu Gly Val Leu Ser 
        275                 280                 285             


Ala Ala Phe Pro Leu His Asp Gly Pro Phe Lys Thr Pro Pro Glu Gly 
    290                 295                 300                 


Pro Gln Ala Pro Arg Leu Asn Gln Arg Gln Val Leu Phe Gln His Trp 
305                 310                 315                 320 


Ala Arg Trp Gly Lys Trp Asn Lys Tyr Gln Pro Leu Asp His Val Arg 
                325                 330                 335     


Arg Tyr Phe Gly Glu Lys Val Ala Leu Tyr Phe Ala Trp Leu Gly Phe 
            340                 345                 350         


Tyr Thr Gly Trp Leu Leu Pro Ala Ala Val Val Gly Thr Leu Val Phe 
        355                 360                 365             


Leu Val Gly Cys Phe Leu Val Phe Ser Asp Ile Pro Thr Gln Glu Leu 
    370                 375                 380                 


Cys Gly Ser Lys Asp Ser Phe Glu Met Cys Pro Leu Cys Leu Asp Cys 
385                 390                 395                 400 


Pro Phe Trp Leu Leu Ser Ser Ala Cys Ala Leu Ala Gln Ala Gly Arg 
                405                 410                 415     


Leu Phe Asp His Gly Gly Thr Val Phe Phe Ser Leu Phe Met Ala Leu 
            420                 425                 430         


Trp Ala Val Leu Leu Leu Glu Tyr Trp Lys Arg Lys Ser Ala Thr Leu 
        435                 440                 445             


Ala Tyr Arg Trp Asp Cys Ser Asp Tyr Glu Asp Thr Glu Glu Arg Pro 
    450                 455                 460                 


Arg Pro Gln Phe Ala Ala Ser Ala Pro Met Thr Ala Pro Asn Pro Ile 
465                 470                 475                 480 


Thr Gly Glu Asp Glu Pro Tyr Phe Pro Glu Arg Ser Arg Ala Arg Arg 
                485                 490                 495     


Met Leu Ala Gly Ser Val Val Ile Val Val Met Val Ala Val Val Val 
            500                 505                 510         


Met Cys Leu Val Ser Ile Ile Leu Tyr Arg Ala Ile Met Ala Ile Val 
        515                 520                 525             


Val Ser Arg Ser Gly Asn Thr Leu Leu Ala Ala Trp Ala Ser Arg Ile 
    530                 535                 540                 


Ala Ser Leu Thr Gly Ser Val Val Asn Leu Val Phe Ile Leu Ile Leu 
545                 550                 555                 560 


Ser Lys Ile Tyr Val Ser Leu Ala His Val Leu Thr Arg Trp Glu Met 
                565                 570                 575     


His Arg Thr Gln Thr Lys Phe Glu Asp Ala Phe Thr Leu Lys Val Phe 
            580                 585                 590         


Ile Phe Gln Phe Val Asn Phe Tyr Ser Ser Pro Val Tyr Ile Ala Phe 
        595                 600                 605             


Phe Lys Gly Arg Phe Val Gly Tyr Pro Gly Asn Tyr His Thr Leu Phe 
    610                 615                 620                 


Gly Val Arg Asn Glu Glu Cys Ala Ala Gly Gly Cys Leu Ile Glu Leu 
625                 630                 635                 640 


Ala Gln Glu Leu Leu Val Ile Met Val Gly Lys Gln Val Ile Asn Asn 
                645                 650                 655     


Met Gln Glu Val Leu Ile Pro Lys Leu Lys Gly Trp Trp Gln Lys Phe 
            660                 665                 670         


Arg Leu Arg Ser Lys Lys Arg Lys Ala Gly Ala Ser Ala Gly Ala Ser 
        675                 680                 685             


Gln Gly Pro Trp Glu Asp Asp Tyr Glu Leu Val Pro Cys Glu Gly Leu 
    690                 695                 700                 


Phe Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Val Thr Ile 
705                 710                 715                 720 


Phe Val Ala Ala Cys Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn Asn 
                725                 730                 735     


Trp Val Glu Ile Arg Leu Asp Ala Arg Lys Phe Val Cys Glu Tyr Arg 
            740                 745                 750         


Arg Pro Val Ala Glu Arg Ala Gln Asp Ile Gly Ile Trp Phe His Ile 
        755                 760                 765             


Leu Ala Gly Leu Thr His Leu Ala Val Ile Ser Asn Ala Phe Leu Leu 
    770                 775                 780                 


Ala Phe Ser Ser Asp Phe Leu Pro Arg Ala Tyr Tyr Arg Trp Thr Arg 
785                 790                 795                 800 


Ala His Asp Leu Arg Gly Phe Leu Asn Phe Thr Leu Ala Arg Ala Pro 
                805                 810                 815     


Ser Ser Phe Ala Ala Ala His Asn Arg Thr Cys Arg Tyr Arg Ala Phe 
            820                 825                 830         


Arg Asp Asp Asp Gly His Tyr Ser Gln Thr Tyr Trp Asn Leu Leu Ala 
        835                 840                 845             


Ile Arg Leu Ala Phe Val Ile Val Phe Glu His Val Val Phe Ser Val 
    850                 855                 860                 


Gly Arg Leu Leu Asp Leu Leu Val Pro Asp Ile Pro Glu Ser Val Glu 
865                 870                 875                 880 


Ile Lys Val Lys Arg Glu Tyr Tyr Leu Ala Lys Gln Ala Leu Ala Glu 
                885                 890                 895     


Asn Glu Val Leu Phe Gly Thr Asn Gly Thr Lys Asp Glu Gln Pro Glu 
            900                 905                 910         


Gly Ser Glu Leu Ser Ser His Trp Thr Pro Phe Thr Val Pro Lys Ala 
        915                 920                 925             


Ser Gln Leu Gln Gln 
    930             


<210>  2877
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NGEP__Homo_sapiens__CCDS33423.1

<400>  2877
augcgaaugg cugccacugc cugggcgggg cuccaagggc caccccuccc cacccucugu       60

cccgcaguga ggacgggacu cuacugccga gaccaggcuc acgcugagag gugggccaug      120

accuccgaga ccucuuccgg aagccacugu gccaggagca ggaugcugcg gcgacgggcc      180

caggaagagg acagcaccgu ccugaucgau gugagccccc cugaggcaga gaagaggggc      240

ucuuacggga gcacagccca cgccucggag ccagguggac agcaagcggc cgccugcaga      300

gcugggaguc cugccaagcc ccggaucgca gacuucgucc ucguuuggga ggaggaccug      360

aagcuagaca ggcagcagga cagugccgcc cgggacagaa cagacaugca caggaccugg      420

cgggagacuu uucuggauaa ucuucgugcg gcugggcugu guguagacca gcaggacguc      480

caggacggga acaccacagu gcacuacgcc cuccucagcg ccuccugggc ugugcucugc      540

uacuacgccg aagaccugcg ccugaagcug cccuugcagg aguuacccaa ccaggccucc      600

aacuggucgg ccggccugcu ggcauggcug ggcaucccca acguccugcu ggagguugug      660

ccagacguac cccccgagua cuacuccugc cgguucagag ugaacaagcu gccacgcuuc      720

cucgggagug acaaccagga caccuucuuc acaagcacca agaggcacca aauucuguuu      780

gagauccugg ccaagacccc guauggccac gagaagaaaa accugcuugg gauccaccag      840

cugcuggcag aggguguccu cagugccgcc uucccccugc augacggccc cuucaagacg      900

cccccagagg gcccgcaggc uccacgccuc aaccagcgcc aaguccuuuu ccagcacugg      960

gcgcgcuggg gcaaguggaa caaguaccag ccccuggacc acgugcgcag guacuucggg     1020

gagaaggugg cccucuacuu cgccuggcuc ggguuuuaca caggcuggcu ccugccagcg     1080

gcaguggugg gcacacuggu guuccuggug ggcugcuucc ugguguucuc agacauaccc     1140

acgcaggaac uguguggcag caaggacagc uucgagaugu gcccacuuug ccucgacugc     1200

ccuuucuggc ugcucuccag cgccugugcc cuggcccagg ccggccggcu guucgaccac     1260

ggcggcaccg uguucuucag cuuguucaug gcacuguggg ccgugcugcu gcuggaguac     1320

uggaagcgga agagcgccac gcuggccuac cgcugggacu gcucugacua cgaggacacu     1380

gaggagaggc cucggcccca guuugccgcc ucagccccca ugacagcccc gaaccccauc     1440

acgggugagg acgagcccua cuucccugag aggagccgcg cgcgccgcau gcuggccggc     1500

ucugugguga ucguggugau gguggccgug guggucaugu gccucguguc uaucauccug     1560

uaccgugcca ucauggccau cguggugucc aggucgggca acacccuucu cgcagccugg     1620

gccucucgca ucgccagccu cacggggucu guagugaacc ucgucuucau ccucauccuc     1680

uccaagaucu auguaucccu ggcccacguc cugacacgau gggaaaugca ccgcacccag     1740

accaaguucg aggacgccuu cacccucaag guguucaucu uccaguucgu caacuucuac     1800

uccucacccg ucuacauugc cuucuucaag ggcagguuug ugggauaccc aggcaacuac     1860

cacaccuugu uuggaguccg caaugaggag ugcgcggcug gaggcugccu gaucgagcug     1920

gcacaggagc uccuggucau cauggugggc aagcagguca ucaacaacau gcaggagguc     1980

cucaucccga agcuaaaggg cugguggcag aaguuccggc uucgcuccaa gaagaggaag     2040

gcgggagcuu cugcaggggc uagccagggg cccugggagg acgacuauga gcuugugccc     2100

ugugaggguc uguuugacga guaccuggaa auggugcugc aguucggcuu cgucaccauc     2160

uucguggccg ccuguccgcu cgcgccgcuc uucgcccugc ucaacaacug gguggagauc     2220

cgcuuggacg cgcgcaaguu cgucugcgag uaccggcgcc cgguggccga gcgcgcccag     2280

gacaucggca ucugguucca cauccuggcg ggccucacgc accuggcggu caucagcaac     2340

gccuuccucc uggccuucuc guccgacuuc cugccgcgcg ccuacuaccg guggacccgc     2400

gcccacgacc ugcgcggcuu ccucaacuuc acgcuggcgc gagccccguc cuccuucgcc     2460

gccgcgcaca accgcacgug cagguaucgg gcuuuccggg augacgaugg acauuauucc     2520

cagaccuacu ggaaucuucu ugccauccgc cuggccuucg ucauuguguu ugagcaugug     2580

guuuucuccg uuggccgccu ccuggaccuc cuggugccug acaucccaga gucuguggag     2640

aucaaaguga agcgggagua cuaccuggcu aagcaggcac uggcugagaa ugagguucuu     2700

uuuggaacga acggaacaaa ggaugagcag cccgagggcu cagagcucag cucccacugg     2760

acacccuuca cgguucccaa ggccagccag cugcagcagu ga                        2802


<210>  2878
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NGEP__Homo_sapiens__CCDS33423.1

<400>  2878
augcgcaugg ccgccaccgc gugggccggc cugcaggggc ccccgcuccc cacccugugc       60

cccgccgugc ggacgggccu guacugccgc gaccaggccc acgccgagcg gugggcgaug      120

accagcgaga ccuccagcgg gucccacugc gcccgcagcc ggaugcuccg ccggcgcgcc      180

caggaggagg acuccaccgu ccugaucgac gugagcccgc ccgaggccga gaagcggggc      240

uccuacggga gcacggcgca cgccuccgag cccggcggcc agcaggccgc cgccugccgc      300

gcggggagcc ccgccaagcc ccggaucgcc gacuucgugc uggucuggga ggaggaccuc      360

aagcuggacc gccagcagga cuccgccgcc cgggaccgca ccgacaugca ccggaccugg      420

cgcgagaccu uccuggacaa ccuccgggcg gccggccugu gcguggacca gcaggacgug      480

caggacggga acacgaccgu ccacuacgcc cugcucagcg ccuccugggc cgugcugugc      540

uacuacgcgg aggaccugcg ccucaagcug ccgcugcagg agcuccccaa ccaggccagc      600

aacugguccg ccggccugcu ggccuggcuc gggaucccca acgugcugcu ggaggucgug      660

cccgacgugc cgcccgagua cuacagcugc cgguuccgcg ucaacaagcu cccccgguuc      720

cugggcuccg acaaccagga caccuucuuc accagcacga agcgccacca gauccuguuc      780

gagauccucg ccaagacccc cuacggccac gagaagaaga accugcuggg gauccaccag      840

cuccuggcgg agggcgugcu guccgccgcc uucccgcucc acgacgggcc cuucaagacc      900

ccgcccgagg gcccccaggc gccccgccug aaccagcgcc aggugcuguu ccagcacugg      960

gcccgguggg gcaaguggaa caaguaccag ccccucgacc acguccggcg cuacuucggg     1020

gagaaggugg cccuguacuu cgccuggcug ggcuucuaca ccggguggcu ccugcccgcc     1080

gccguggucg gcacgcuggu guuccucgug gggugcuucc uggucuucag cgacaucccg     1140

acccaggagc ugugcggcag caaggacucc uucgagaugu gcccccucug ccuggacugc     1200

cccuucuggc ugcucagcuc cgcgugcgcc cuggcccagg ccggccggcu guucgaccac     1260

gggggcaccg uguucuucag ccuguucaug gcccucuggg cggugcugcu gcucgaguac     1320

uggaagcgca aguccgccac ccuggccuac cggugggacu gcagcgacua cgaggacacg     1380

gaggagcgcc cccggccgca guucgccgcc uccgcgccca ugaccgcccc caacccgauc     1440

accggggagg acgagcccua cuuccccgag cgcagccggg cccgccggau gcuggccggc     1500

uccgucguga ucgucgugau gguggcgguc guggugaugu gccucgucag caucauccug     1560

uaccgcgcca ucauggccau cguggugucc cggagcggga acacccugcu cgccgccugg     1620

gcgucccgca ucgccagccu gacgggcucc gucgugaacc ugguguucau ccucauccug     1680

agcaagaucu acgucucccu ggcccacgug cucacccggu gggagaugca ccgcacccag     1740

accaaguucg aggacgccuu cacgcugaag guguucaucu uccaguucgu caacuucuac     1800

agcucccccg uguacaucgc cuucuucaag ggccgguucg ugggguaccc gggcaacuac     1860

cacacccugu ucgggguccg caacgaggag ugcgcggccg gcgggugccu caucgagcug     1920

gcccaggagc ugcucgugau cauggugggc aagcagguca ucaacaacau gcaggaggug     1980

cugaucccca agcugaaggg cugguggcag aaguuccgcc uccggagcaa gaagcgcaag     2040

gccggggcca gcgcgggcgc cucccagggg cccugggagg acgacuacga gcuggugccc     2100

ugcgagggcc uguucgacga guaccucgag augguccugc aguucggcuu cgugaccauc     2160

uucguggccg ccugcccgcu ggcgccccuc uucgcccugc ugaacaacug ggucgagauc     2220

cggcucgacg cccgcaaguu cgugugcgag uaccggcgcc ccguggccga gcgggcccag     2280

gacaucggga ucugguucca cauccuggcg ggccugaccc accucgccgu caucagcaac     2340

gccuuccugc uggccuucuc cagcgacuuc cucccccgcg ccuacuaccg guggacgcgc     2400

gcgcacgacc ugcggggguu ccugaacuuc acccucgccc gcgccccguc cagcuucgcc     2460

gccgcgcaca accggaccug ccgcuaccgg gccuuccgcg acgacgacgg ccacuacucc     2520

cagaccuacu ggaaccugcu ggccauccgg cucgccuucg ugaucguguu cgagcacguc     2580

guguucagcg uggggcgccu gcuggaccuc cugguccccg acauccccga guccguggag     2640

aucaagguga agcgggagua cuaccuggcc aagcaggcgc ucgccgagaa cgagguccug     2700

uucggcacga acggcaccaa ggacgagcag cccgagggga gcgagcuguc cagccacugg     2760

accccguuca ccgugcccaa ggccucccag cuccagcagu ga                        2802


<210>  2879
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NGEP__Homo_sapiens__CCDS33423.1

<400>  2879
augcgcaugg ccgccaccgc cugggccggc cuccagggcc ccccccuccc cacccucugc       60

cccgccgucc gcaccggccu cuacugccgc gaccaggccc acgccgagcg cugggccaug      120

accuccgaga ccuccuccgg cucccacugc gcccgcuccc gcaugcuccg ccgccgcgcc      180

caggaggagg acuccaccgu ccucaucgac gucucccccc ccgaggccga gaagcgcggc      240

uccuacggcu ccaccgccca cgccuccgag cccggcggcc agcaggccgc cgccugccgc      300

gccggcuccc ccgccaagcc ccgcaucgcc gacuucgucc ucgucuggga ggaggaccuc      360

aagcucgacc gccagcagga cuccgccgcc cgcgaccgca ccgacaugca ccgcaccugg      420

cgcgagaccu uccucgacaa ccuccgcgcc gccggccucu gcgucgacca gcaggacguc      480

caggacggca acaccaccgu ccacuacgcc cuccucuccg ccuccugggc cguccucugc      540

uacuacgccg aggaccuccg ccucaagcuc ccccuccagg agcuccccaa ccaggccucc      600

aacugguccg ccggccuccu cgccuggcuc ggcaucccca acguccuccu cgaggucguc      660

cccgacgucc cccccgagua cuacuccugc cgcuuccgcg ucaacaagcu cccccgcuuc      720

cucggcuccg acaaccagga caccuucuuc accuccacca agcgccacca gauccucuuc      780

gagauccucg ccaagacccc cuacggccac gagaagaaga accuccucgg cauccaccag      840

cuccucgccg agggcguccu cuccgccgcc uucccccucc acgacggccc cuucaagacc      900

ccccccgagg gcccccaggc cccccgccuc aaccagcgcc agguccucuu ccagcacugg      960

gcccgcuggg gcaaguggaa caaguaccag ccccucgacc acguccgccg cuacuucggc     1020

gagaaggucg cccucuacuu cgccuggcuc ggcuucuaca ccggcuggcu ccuccccgcc     1080

gccgucgucg gcacccucgu cuuccucguc ggcugcuucc ucgucuucuc cgacaucccc     1140

acccaggagc ucugcggcuc caaggacucc uucgagaugu gcccccucug ccucgacugc     1200

cccuucuggc uccucuccuc cgccugcgcc cucgcccagg ccggccgccu cuucgaccac     1260

ggcggcaccg ucuucuucuc ccucuucaug gcccucuggg ccguccuccu ccucgaguac     1320

uggaagcgca aguccgccac ccucgccuac cgcugggacu gcuccgacua cgaggacacc     1380

gaggagcgcc cccgccccca guucgccgcc uccgccccca ugaccgcccc caaccccauc     1440

accggcgagg acgagcccua cuuccccgag cgcucccgcg cccgccgcau gcucgccggc     1500

uccgucguca ucgucgucau ggucgccguc gucgucaugu gccucgucuc caucauccuc     1560

uaccgcgcca ucauggccau cgucgucucc cgcuccggca acacccuccu cgccgccugg     1620

gccucccgca ucgccucccu caccggcucc gucgucaacc ucgucuucau ccucauccuc     1680

uccaagaucu acgucucccu cgcccacguc cucacccgcu gggagaugca ccgcacccag     1740

accaaguucg aggacgccuu cacccucaag gucuucaucu uccaguucgu caacuucuac     1800

uccucccccg ucuacaucgc cuucuucaag ggccgcuucg ucggcuaccc cggcaacuac     1860

cacacccucu ucggcguccg caacgaggag ugcgccgccg gcggcugccu caucgagcuc     1920

gcccaggagc uccucgucau cauggucggc aagcagguca ucaacaacau gcaggagguc     1980

cucaucccca agcucaaggg cugguggcag aaguuccgcc uccgcuccaa gaagcgcaag     2040

gccggcgccu ccgccggcgc cucccagggc cccugggagg acgacuacga gcucgucccc     2100

ugcgagggcc ucuucgacga guaccucgag augguccucc aguucggcuu cgucaccauc     2160

uucgucgccg ccugcccccu cgccccccuc uucgcccucc ucaacaacug ggucgagauc     2220

cgccucgacg cccgcaaguu cgucugcgag uaccgccgcc ccgucgccga gcgcgcccag     2280

gacaucggca ucugguucca cauccucgcc ggccucaccc accucgccgu caucuccaac     2340

gccuuccucc ucgccuucuc cuccgacuuc cucccccgcg ccuacuaccg cuggacccgc     2400

gcccacgacc uccgcggcuu ccucaacuuc acccucgccc gcgcccccuc cuccuucgcc     2460

gccgcccaca accgcaccug ccgcuaccgc gccuuccgcg acgacgacgg ccacuacucc     2520

cagaccuacu ggaaccuccu cgccauccgc cucgccuucg ucaucgucuu cgagcacguc     2580

gucuucuccg ucggccgccu ccucgaccuc cucguccccg acauccccga guccgucgag     2640

aucaagguca agcgcgagua cuaccucgcc aagcaggccc ucgccgagaa cgagguccuc     2700

uucggcacca acggcaccaa ggacgagcag cccgagggcu ccgagcucuc cucccacugg     2760

acccccuuca ccguccccaa ggccucccag cuccagcagu ga                        2802


<210>  2880
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NGEP__Homo_sapiens__CCDS33423.1

<400>  2880
augagaaugg ccgcuaccgc augggccggc cugcaggggc ccccucuccc aacacuuugc       60

ccggcgguga ggacuggacu guacugucgg gaccaagcuc acgccgagcg cugggcaaug      120

acgagcgaaa ccuccucugg uucacauugc gcccgaaguc guauguugag aaggcgggcu      180

caggaggaag auagcacagu cuuaaucgac guuucacccc cugaggcaga aaagcgcggc      240

ucuuaugggu cgacugccca cgcuucagag ccaggaggcc agcaggccgc ggcauguaga      300

gccgguagcc ccgcuaaacc uaggauugcc gauuucgugc ugguauggga ggaagaccua      360

aagcucgauc ggcaacagga cagugcagcu cgcgaucgaa ccgacaugca uagaacaugg      420

agggagaccu uucuggauaa ccuucgggcc gcggggcugu gcguggacca gcaggauguc      480

caagacggaa auacuacagu gcacuacgcc uugcucuccg caucuugggc uguucugugu      540

uauuacgccg aagaucugcg ucucaaauua ccacugcagg agcuucccaa ccaggcuagc      600

aauugguccg ccggcuugcu ggcauggcua ggcauaccua acgugcuccu ggaggucgug      660

ccagacguac cgcccgaaua uuacucaugc cgcuucagag uuaauaaacu uccuagguuu      720

cuggggagug acaaccagga uaccuucuuu acgagcacua agcggcauca aaucuuguuc      780

gagauucucg ccaagacccc auauggacac gaaaagaaaa aucuguuagg uauccaccag      840

cugcucgcug agggcgugcu uucugcggca uuuccccugc augacgggcc uuucaagaca      900

ccacccgaag gaccgcaggc cccucgauug aaccaacgcc agguccuauu ucagcacugg      960

gcuagauggg gcaaauggaa uaaguaccag ccccuggauc augugaggcg guacuucggu     1020

gagaaagugg cccucuauuu ugcauggcug ggguucuaca cuggauggcu ucugccagcc     1080

gcugucguug gcaccuuggu guuucucgua ggcuguuucc ugguguucuc cgacauuccu     1140

acacaagagu uaugcggguc aaaggauagc uuugaaaugu guccccugug ccuagacugu     1200

ccauucuggc uccugaguuc ugccugcgca cuugcgcagg cuggacgcuu guuugaucac     1260

gguggcaccg ucuucuuuuc ccuguucaug gcccucuggg cagugcugcu ucuggaguau     1320

uggaagagaa aaagcgccac guuggcuuac aggugggacu gcucggauua ugaagacacu     1380

gaggaacguc cccggccuca guuugccgca ucugcuccaa ugacagcccc gaaccccauc     1440

accggggagg augagccuua cuucccagaa cgauccagag cgaggcgcau gcucgccgga     1500

ucaguuguga uagucgugau gguagcuguu guggucaugu gucuggugag uaucauuuua     1560

uaucgggcaa ucauggccau ugucgugagc agauccggca auacucugcu agcugccugg     1620

gcaucuagga ucgcgagccu cacagguuca guugugaacc ugguauuuau acuuauuuug     1680

aguaagaucu acgucucccu ggcccacgug cucacccgcu gggagaugca ucgaacgcag     1740

accaaauucg aagacgcuuu uacacugaag guuuucauuu uucaauucgu gaauuucuac     1800

agcucucccg ucuauaucgc cuuuuucaaa gggcgguuug ugggcuaccc uggaaacuau     1860

cacacuuuau ucggcguacg uaaugaggaa ugcgcagcug ggggaugucu gaucgagcuu     1920

gcccaggagu ugcucgugau uaugguuggu aagcagguca uaaacaacau gcaggaagug     1980

cugaucccaa aacuaaaggg cugguggcaa aaguuuagac ugagguccaa aaagcgcaaa     2040

gcaggggcca gugcuggagc gagccagggc cccugggagg acgauuacga acucgugccg     2100

ugcgaggguc uguucgacga guaucuugaa auggucuugc aguuuggguu cguuaccauu     2160

uuuguggccg cauguccucu ggcuccauua uucgcccucc ugaauaacug gguggagauc     2220

cggcuugaug ccagaaaguu uguaugcgaa uacaggcgac ccgucgcuga gcgcgcacag     2280

gacauaggca uuugguucca uauccuggcc ggauugacac accucgcggu gaucuccaau     2340

gcuuuucugc uagccuucuc uucggauuuc cugccucggg cauauuacag auggacuagg     2400

gcccaugacc uccguggcuu ucugaacuuc acccuugcuc gcgcacccag cuccuuugcc     2460

gcggcucaca aucggacaug uagauacagg gccuuccgag augacgaugg gcacuauuca     2520

caaaccuacu ggaacuugcu ggcaauucgg uuagccuuug uuaucguguu cgaacauguc     2580

guguuuagug uuggacgccu ccuggaccuu cuggugccag auauuccuga gucuguagag     2640

auaaaaguca agagagaaua uuaccuagcu aagcaggccc ucgcagagaa ugaagugcug     2700

uucgguacua acggcacgaa agacgagcag cccgaaggga gcgaguuguc cucacacugg     2760

acaccauuua ccgugccgaa ggcuagccaa cugcagcagu ga                        2802


<210>  2881
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NGEP__Homo_sapiens__CCDS33423.1

<400>  2881
augagaaugg ccgccaccgc cugggccggc cugcagggcc ccccccugcc cacccugugc       60

cccgccguga gaaccggccu guacugcaga gaccaggccc acgccgagag augggccaug      120

accagcgaga ccagcagcgg cagccacugc gccagaagca gaaugcugag aagaagagcc      180

caggaggagg acagcaccgu gcugaucgac gugagccccc ccgaggccga gaagagaggc      240

agcuacggca gcaccgccca cgccagcgag cccggcggcc agcaggccgc cgccugcaga      300

gccggcagcc ccgccaagcc cagaaucgcc gacuucgugc ugguguggga ggaggaccug      360

aagcuggaca gacagcagga cagcgccgcc agagacagaa ccgacaugca cagaaccugg      420

agagagaccu uccuggacaa ccugagagcc gccggccugu gcguggacca gcaggacgug      480

caggacggca acaccaccgu gcacuacgcc cugcugagcg ccagcugggc cgugcugugc      540

uacuacgccg aggaccugag acugaagcug ccccugcagg agcugcccaa ccaggccagc      600

aacuggagcg ccggccugcu ggccuggcug ggcaucccca acgugcugcu ggagguggug      660

cccgacgugc cccccgagua cuacagcugc agauucagag ugaacaagcu gcccagauuc      720

cugggcagcg acaaccagga caccuucuuc accagcacca agagacacca gauccuguuc      780

gagauccugg ccaagacccc cuacggccac gagaagaaga accugcuggg cauccaccag      840

cugcuggccg agggcgugcu gagcgccgcc uucccccugc acgacggccc cuucaagacc      900

ccccccgagg gcccccaggc ccccagacug aaccagagac aggugcuguu ccagcacugg      960

gccagauggg gcaaguggaa caaguaccag ccccuggacc acgugagaag auacuucggc     1020

gagaaggugg cccuguacuu cgccuggcug ggcuucuaca ccggcuggcu gcugcccgcc     1080

gccguggugg gcacccuggu guuccuggug ggcugcuucc ugguguucag cgacaucccc     1140

acccaggagc ugugcggcag caaggacagc uucgagaugu gcccccugug ccuggacugc     1200

cccuucuggc ugcugagcag cgccugcgcc cuggcccagg ccggcagacu guucgaccac     1260

ggcggcaccg uguucuucag ccuguucaug gcccuguggg ccgugcugcu gcuggaguac     1320

uggaagagaa agagcgccac ccuggccuac agaugggacu gcagcgacua cgaggacacc     1380

gaggagagac ccagacccca guucgccgcc agcgccccca ugaccgcccc caaccccauc     1440

accggcgagg acgagcccua cuuccccgag agaagcagag ccagaagaau gcuggccggc     1500

agcgugguga ucguggugau gguggccgug guggugaugu gccuggugag caucauccug     1560

uacagagcca ucauggccau cguggugagc agaagcggca acacccugcu ggccgccugg     1620

gccagcagaa ucgccagccu gaccggcagc guggugaacc ugguguucau ccugauccug     1680

agcaagaucu acgugagccu ggcccacgug cugaccagau gggagaugca cagaacccag     1740

accaaguucg aggacgccuu cacccugaag guguucaucu uccaguucgu gaacuucuac     1800

agcagccccg uguacaucgc cuucuucaag ggcagauucg ugggcuaccc cggcaacuac     1860

cacacccugu ucggcgugag aaacgaggag ugcgccgccg gcggcugccu gaucgagcug     1920

gcccaggagc ugcuggugau cauggugggc aagcagguga ucaacaacau gcaggaggug     1980

cugaucccca agcugaaggg cugguggcag aaguucagac ugagaagcaa gaagagaaag     2040

gccggcgcca gcgccggcgc cagccagggc cccugggagg acgacuacga gcuggugccc     2100

ugcgagggcc uguucgacga guaccuggag auggugcugc aguucggcuu cgugaccauc     2160

uucguggccg ccugcccccu ggccccccug uucgcccugc ugaacaacug gguggagauc     2220

agacuggacg ccagaaaguu cgugugcgag uacagaagac ccguggccga gagagcccag     2280

gacaucggca ucugguucca cauccuggcc ggccugaccc accuggccgu gaucagcaac     2340

gccuuccugc uggccuucag cagcgacuuc cugcccagag ccuacuacag auggaccaga     2400

gcccacgacc ugagaggcuu ccugaacuuc acccuggcca gagcccccag cagcuucgcc     2460

gccgcccaca acagaaccug cagauacaga gccuucagag acgacgacgg ccacuacagc     2520

cagaccuacu ggaaccugcu ggccaucaga cuggccuucg ugaucguguu cgagcacgug     2580

guguucagcg ugggcagacu gcuggaccug cuggugcccg acauccccga gagcguggag     2640

aucaagguga agagagagua cuaccuggcc aagcaggccc uggccgagaa cgaggugcug     2700

uucggcacca acggcaccaa ggacgagcag cccgagggca gcgagcugag cagccacugg     2760

acccccuuca ccgugcccaa ggccagccag cugcagcagu ga                        2802


<210>  2882
<211>  2802
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NGEP__Homo_sapiens__CCDS33423.1

<400>  2882
augagaaugg ccgcuaccgc cugggcgggc cugcaggggc ccccucuccc gacacugugc       60

cccgcugugc ggacgggacu uuacugucgc gaccaagccc acgccgagag augggcuaug      120

accagcgaaa cauccucugg cagccauugc gcccgguccc gcaugcugag acggcgcgcu      180

caggaggaag auucuaccgu ccucaucgac guuagcccuc ccgaggccga aaagagaggg      240

uccuauggau cuacagcgca cgccagcgag ccuggcgggc agcaggcugc cgcuugucgg      300

gccggauccc ccgcgaaacc ucgcauugcc gauuucgugc ugguguggga ggaagaccuu      360

aagcuggaua gacaacagga cagcgcugcc cgggaucgca ccgacaugca uagaacaugg      420

cgggagaccu uucucgauaa ccugcgcgcu gccggccugu gcgucgacca gcaggaugug      480

caagacggca auacgaccgu ucacuacgcc cuccugucug cuuccugggc ggugcuuugu      540

uauuacgccg aagaucugag acucaaacug ccgcuucagg agcugcccaa ccaggcuagc      600

aauuggucug ccgggcuccu ggccuggcug ggaaucccua acguccuccu ggaggugguu      660

cccgacgugc cucccgaaua uuacuccugc cgguucagag ucaauaaacu uccgcgcuuu      720

cugggcagcg acaaccagga uacauucuuu accucuacaa agcggcauca aauucucuuc      780

gagauccugg cuaagacccc uuaugggcac gaaaagaaaa aucuucuggg cauucaccag      840

cuccuggccg agggagugcu guccgcggcu uuuccccucc augacgggcc uuucaagacg      900

ccucccgaag gaccccaggc cccgagacug aaccaacgcc aggugcuuuu ucagcacugg      960

gcccgguggg gcaaauggaa uaaguaccag ccccuggauc augucagacg cuacuucggc     1020

gagaaaguug cucucuauuu ugccuggcug ggguucuaca caggauggcu ucugccugcu     1080

gccguggugg gcacccucgu cuuucuggug ggguguuucc ugguuuucag cgacaucccc     1140

acacaagagc ucugcggauc caaggauucu uuugaaaugu guccucugug ccuugacugu     1200

cccuucuggc ugcucagcuc cgcgugcgcc cuggcucagg ccggccggcu guuugaucac     1260

gggggaaccg uguucuuuag ccuuuucaug gcucucuggg ccguccugcu gcucgaguau     1320

uggaagagaa aaucugcgac ccuggccuac cgcugggacu gcuccgauua ugaagacaca     1380

gaggaacggc cgagaccuca guuugcugcc agcgcuccca ugacggcccc uaaccccauc     1440

accggcgagg augagccuua cuuccccgaa cgcucucggg ccagacggau gcuugcuggc     1500

agcgugguua uuguggucau gguggcgguc gugguuaugu gucugguguc caucauucuc     1560

uaucgcgcca ucauggcuau ugucgugucu agaagcggga auacacugcu ggccgccugg     1620

gcuucccgga ucgccagccu uaccggaucu guugugaacc ucgucuuuau ucugauccug     1680

uccaagaucu acgugagccu cgcgcacgug cugacaagau gggagaugca ucgcacccag     1740

acgaaauucg aagacgcuuu uacacuuaag guuuucauuu uucaauucgu caauuucuac     1800

ucuuccccgg uguauaucgc cuuuuucaaa ggccgguuug ugggguaccc uggaaacuau     1860

cacacccugu ucggcgucag aaaugaggaa ugcgccgcug ggggcugucu cauugagcug     1920

gcccaggagc ugcuugugau caugguugga aagcagguua uuaacaacau gcaggaaguc     1980

cucaucccca aacugaaggg cugguggcaa aaguuucgcc ugagaagcaa aaagcggaaa     2040

gcgggggcuu ccgccggagc cucucagggc cccugggagg acgauuacga acucgugccu     2100

ugcgaggggc uguucgacga guaucuugaa augguucugc aguuuggauu cgugaccauc     2160

uuugucgcug ccuguccgcu cgcuccccug uucgcccugc uuaauaacug gguggagauu     2220

cgccucgaug cgagaaaguu uguuugcgaa uaccggcgcc cuguggccga gagagcucag     2280

gacaucggca uuugguucca uauccuggcc gggcugacac accucgcugu cauuagcaau     2340

gccuuucugc uugccuucuc cucugauuuc cugccccggg cuuauuaccg cuggaccaga     2400

gcgcaugacc uccggggcuu ucugaacuuc acacuggccc gcgcuccuag cuccuuugcc     2460

gccgcucaca auagaacgug ucgguacaga gccuuccgcg augacgaugg acacuauagc     2520

caaaccuacu ggaaccuucu ggcgauccgg cucgcuuuug ugaucguguu cgaacauguc     2580

guguuuucug ugggcagacu gcucgaccug cuugugcccg auauuccuga guccgucgag     2640

aucaaaguga agcgcgaaua uuaccuggcc aagcaggccc ucgcugagaa ugaaguucug     2700

uucgggacaa acggaaccaa agacgagcag cccgaaggca gcgagcuguc uucccacugg     2760

acaccguuua ccgugccuaa ggccagccaa cuucagcagu ga                        2802


<210>  2883
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NPM__Homo_sapiens__P06748

<400>  2883

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
    130                 135                 140                 


Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                165                 170                 175     


Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
            180                 185                 190         


Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
        195                 200                 205             


Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
    210                 215                 220                 


Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
225                 230                 235                 240 


Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                245                 250                 255     


Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
            260                 265                 270         


Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
        275                 280                 285             


Gln Trp Arg Lys Ser Leu 
    290                 


<210>  2884
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NPM__Homo_sapiens__AAA36380

<400>  2884
auggaagauu cgauggacau ggacaugagc ccccugaggc cccagaacua ucuuuucggu       60

ugugaacuaa aggccgacaa agauuaucac uuuaaggugg auaaugauga aaaugagcac      120

caguuaucuu uaagaacggu caguuuaggg gcuggugcaa aggaugaguu gcacauuguu      180

gaagcagagg caaugaauua cgaaggcagu ccaauuaaag uaacacuggc aacuuugaaa      240

augucuguac agccaacggu uucccuuggg ggcuuugaaa uaacaccacc aguggucuua      300

agguugaagu gugguucagg gccagugcau auuaguggac agcacuuagu agcuguggag      360

gaagaugcag agucagaaga ugaagaggag gaggauguga aacucuuaag uauaucugga      420

aagcggucug ccccuggagg ugguagcaag guuccacaga aaaaaguaaa acuugcugcu      480

gaugaagaug augacgauga ugaugaagag gaugaugaug aagaugauga ugaugaugau      540

uuugaugaug aggaagcuga agaaaaagcg ccagugaaga aaucuauacg agauacucca      600

gccaaaaaug cacaaaaguc aaaucagaau ggaaaagacu caaaaccauc aucaacacca      660

agaucaaaag gacaagaauc cuucaagaaa caggaaaaaa cuccuaaaac accaaaagga      720

ccuaguucug uagaagacau uaaagcaaaa augcaagcaa guauagaaaa aggugguucu      780

cuucccaaag uggaagccaa auucaucaau uaugugaaga auugcuuccg gaugacugac      840

caagaggcua uucaagaucu cuggcagugg aggaagucuc uuuaa                      885


<210>  2885
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NPM__Homo_sapiens__AAA36380

<400>  2885
auggaggaca gcauggacau ggacaugagc ccccugcggc cgcagaacua ccucuucggc       60

ugcgagcuga aggccgacaa ggacuaccac uucaaggugg acaacgacga gaacgagcac      120

cagcugagcc uccggaccgu cucccugggg gccggcgcga aggacgagcu gcacaucgug      180

gaggccgagg ccaugaacua cgaggggagc cccaucaagg ugacccucgc cacgcugaag      240

auguccgucc agcccaccgu gagccugggc ggguucgaga ucaccccgcc cgugguccuc      300

cgccugaagu gcggcuccgg ccccgugcac aucagcgggc agcaccuggu ggccgucgag      360

gaggacgcgg aguccgagga cgaggaggag gaggacguga agcuccugag caucuccggc      420

aagcggagcg cccccggggg cggguccaag gugccccaga agaaggucaa gcuggccgcc      480

gacgaggacg acgacgacga cgacgaggag gacgacgacg aggacgacga cgacgacgac      540

uucgacgacg aggaggcgga ggagaaggcc ccggugaaga aguccauccg cgacaccccc      600

gccaagaacg cccagaaguc caaccagaac ggcaaggaca gcaagcccuc cagcacgccc      660

cgguccaagg gccaggagag cuucaagaag caggagaaga ccccgaagac ccccaagggg      720

cccagcuccg uggaggacau caaggccaag augcaggcga gcaucgagaa gggcgggucc      780

cuccccaagg ucgaggccaa guucaucaac uacgugaaga acugcuuccg caugaccgac      840

caggaggcca uccaggaccu guggcagugg cgcaagagcc uguga                      885


<210>  2886
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NPM__Homo_sapiens__AAA36380

<400>  2886
auggaggacu ccauggacau ggacaugucc ccccuccgcc cccagaacua ccucuucggc       60

ugcgagcuca aggccgacaa ggacuaccac uucaaggucg acaacgacga gaacgagcac      120

cagcucuccc uccgcaccgu cucccucggc gccggcgcca aggacgagcu ccacaucguc      180

gaggccgagg ccaugaacua cgagggcucc cccaucaagg ucacccucgc cacccucaag      240

auguccgucc agcccaccgu cucccucggc ggcuucgaga ucaccccccc cgucguccuc      300

cgccucaagu gcggcuccgg ccccguccac aucuccggcc agcaccucgu cgccgucgag      360

gaggacgccg aguccgagga cgaggaggag gaggacguca agcuccucuc caucuccggc      420

aagcgcuccg cccccggcgg cggcuccaag gucccccaga agaaggucaa gcucgccgcc      480

gacgaggacg acgacgacga cgacgaggag gacgacgacg aggacgacga cgacgacgac      540

uucgacgacg aggaggccga ggagaaggcc cccgucaaga aguccauccg cgacaccccc      600

gccaagaacg cccagaaguc caaccagaac ggcaaggacu ccaagcccuc cuccaccccc      660

cgcuccaagg gccaggaguc cuucaagaag caggagaaga cccccaagac ccccaagggc      720

cccuccuccg ucgaggacau caaggccaag augcaggccu ccaucgagaa gggcggcucc      780

cuccccaagg ucgaggccaa guucaucaac uacgucaaga acugcuuccg caugaccgac      840

caggaggcca uccaggaccu cuggcagugg cgcaaguccc ucuga                      885


<210>  2887
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NPM__Homo_sapiens__AAA36380

<400>  2887
auggaggaca gcauggauau ggacaugucu ccccugagac cucagaacua ccucuucggc       60

ugcgaacuua aggccgauaa agacuaucac uuuaaggugg auaaugacga gaacgaacau      120

caacuguccu ugaggaccgu cucauuaggg gcuggagcaa aagaugagcu gcacaucguu      180

gaagccgagg cgaugaauua cgaggguagu ccaauuaagg ugacacuagc uacucucaaa      240

augagcguac agccgacggu gucccugggc ggguucgaaa uaacaccccc ugucgugcuu      300

cggcugaagu guggaucugg cccaguucau aucucggguc agcacuuggu ggccgucgag      360

gaagacgcag agucagagga ugaagaggaa gaggacguga agcuccugag cauuaguggg      420

aaacgcuccg cccccggagg cggcucuaag guaccucaga aaaagguuaa acuggcugca      480

gaugaagacg augacgacga ugacgaggag gaugacgaug aagacgauga cgaugacgau      540

uuugacgacg aggaagccga ggaaaaggcu ccagugaaga aaagcauccg agauaccccc      600

gccaagaacg cgcaaaaauc caaucagaac gggaaggacu caaaaccuag uagcacucca      660

cguucuaagg gacaggaguc cuucaaaaag caggagaaga ccccgaaaac acccaagggu      720

ccuucaagcg ucgaagauau uaaagcaaag augcaagcca guaucgagaa aggcgggucu      780

cucccaaagg uggaagcuaa guuuauaaau uaugugaaaa acugcuucag aaugaccgac      840

caggaggcca uccaggauuu auggcagugg aggaaguccc uguga                      885


<210>  2888
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NPM__Homo_sapiens__AAA36380

<400>  2888
auggaggaca gcauggacau ggacaugagc ccccugagac cccagaacua ccuguucggc       60

ugcgagcuga aggccgacaa ggacuaccac uucaaggugg acaacgacga gaacgagcac      120

cagcugagcc ugagaaccgu gagccugggc gccggcgcca aggacgagcu gcacaucgug      180

gaggccgagg ccaugaacua cgagggcagc cccaucaagg ugacccuggc cacccugaag      240

augagcgugc agcccaccgu gagccugggc ggcuucgaga ucaccccccc cguggugcug      300

agacugaagu gcggcagcgg ccccgugcac aucagcggcc agcaccuggu ggccguggag      360

gaggacgccg agagcgagga cgaggaggag gaggacguga agcugcugag caucagcggc      420

aagagaagcg cccccggcgg cggcagcaag gugccccaga agaaggugaa gcuggccgcc      480

gacgaggacg acgacgacga cgacgaggag gacgacgacg aggacgacga cgacgacgac      540

uucgacgacg aggaggccga ggagaaggcc cccgugaaga agagcaucag agacaccccc      600

gccaagaacg cccagaagag caaccagaac ggcaaggaca gcaagcccag cagcaccccc      660

agaagcaagg gccaggagag cuucaagaag caggagaaga cccccaagac ccccaagggc      720

cccagcagcg uggaggacau caaggccaag augcaggcca gcaucgagaa gggcggcagc      780

cugcccaagg uggaggccaa guucaucaac uacgugaaga acugcuucag aaugaccgac      840

caggaggcca uccaggaccu guggcagugg agaaagagcc uguga                      885


<210>  2889
<211>  885
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NPM__Homo_sapiens__AAA36380

<400>  2889
auggaggaca gcauggauau ggacaugagc ccccugagac cucagaacua ccucuucggc       60

ugcgaacuga aggccgauaa agacuaucac uuuaaggugg auaaugacga gaacgaacau      120

caacuuucuc ugcggaccgu cagccucggg gcuggagcca aagaugagcu gcacaucguu      180

gaagcggagg cuaugaauua cgagggcucc ccgauuaagg ugacacuugc cacgcugaaa      240

augucugugc agcccaccgu cagccucggg ggauucgaaa ucacaccucc cgugguucug      300

cgccugaagu guggcuccgg gccugugcau auuucuggac agcaccucgu cgccguggag      360

gaagacgcug agagcgagga ugaagaggaa gaggacguua agcugcuuuc caucagcggc      420

aaaagaucug cccccggcgg gggauccaag gugccucaga aaaaggucaa acuggcugcc      480

gaugaagacg augacgacga ugacgaggag gaugacgaug aagacgauga cgaugacgau      540

uuugacgacg aggaagcgga ggaaaaggcc ccggugaaga aaagcauucg ggauaccccc      600

gcuaagaacg cccaaaaauc uaaucagaac ggcaaggacu ccaaaccuag cucuacaccc      660

cgcuccaagg ggcaggagag cuucaaaaag caggagaaga ccccuaaaac acccaaggga      720

ccguccucug uggaagauau caaagcuaag augcaagcca gcaucgagaa aggcgggucc      780

cucccuaagg ucgaagcgaa guuuauuaau uauguuaaaa acugcuucag aaugaccgac      840

caggaggcca uccaggaucu guggcagugg cggaaguccc uuuga                      885


<210>  2890
<211>  1304
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NRCAM__Homo_sapiens__Q92823

<400>  2890

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala 
        995                 1000                1005            


Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr 
    1010                1015                1020                


Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile 
1025                1030                1035                1040


Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro 
                1045                1050                1055    


Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Pro Arg Ile Ser Asn 
            1060                1065                1070        


Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr 
        1075                1080                1085            


Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly 
    1090                1095                1100                


Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe 
1105                1110                1115                1120


Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val 
                1125                1130                1135    


Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu 
            1140                1145                1150        


Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly 
        1155                1160                1165            


Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu 
    1170                1175                1180                


Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val 
1185                1190                1195                1200


Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys 
                1205                1210                1215    


Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys 
            1220                1225                1230        


Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys 
        1235                1240                1245            


Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly 
    1250                1255                1260                


Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys 
1265                1270                1275                1280


Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro 
                1285                1290                1295    


Val Asn Ala Met Asn Ser Phe Val 
            1300                


<210>  2891
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NRCAM__Homo_sapiens__CCDS47686.1

<400>  2891
augcagcuua aaauaaugcc gaaaaagaag cgcuuaucug cgggcagagu gccccugauu       60

cucuuccugu gccagaugau uagugcacug gaaguaccuc uugauccaaa acuucuugaa      120

gacuugguac agccuccaac caucacccaa cagucuccaa aagauuacau uauugacccu      180

cgggagaaua uuguaaucca gugugaagcc aaagggaaac cgcccccaag cuuuuccugg      240

acccguaaug ggacucauuu ugacaucgau aaagacccuc uggucaccau gaagccuggc      300

acaggaacgc ucauaauuaa caucaugagc gaagggaaag cugagaccua ugaaggaguc      360

uaucagugua cagcaaggaa cgaacgcgga gcugcaguuu cuaauaacau uguuguccgc      420

ccauccagau caccauugug gaccaaagaa aaacuugaac caaucacacu ucaaaguggu      480

cagucuuuag uacuucccug cagaccccca auuggauuac caccaccuau aauauuuugg      540

auggauaauu ccuuucaaag acuuccacaa agugagagag uuucucaagg uuugaauggg      600

gaccuuuauu uuuccaaugu ccucccagag gacacccgcg aagacuauau cuguuaugcu      660

agauuuaauc auacucaaac cauacagcag aagcaaccua uuucugugaa ggugauuuca      720

guggaugaau ugaaugacac uauagcugcu aauuugagug acacugaguu uuauggugcu      780

aaaucaagua gagagaggcc accaacauuu uuaacuccag aaggcaaugc aaguaacaaa      840

gaggaauuaa gaggaaaugu gcuuucacug gagugcauug cagaaggacu gccuacccca      900

auuauuuacu gggcaaagga agauggaaug cuacccaaaa acaggacagu uuauaagaac      960

uuugagaaaa ccuugcagau cauucauguu ucagaagcag acucuggaaa uuaccaaugu     1020

auagcaaaaa acgcauuagg agccauccac cauaccauuu cuguuagagu uaaagcggcu     1080

ccauacugga ucacagcccc ucaaaaucuu gugcuguccc caggagagga ugggaccuug     1140

aucugcagag cuaauggcaa ccccaaaccc agaauuagcu gguuaacaaa uggaguccca     1200

auagaaauug ccccugauga ccccagcaga aaaauagaug gcgauaccau uauuuuuuca     1260

aauguucaag aaagaucaag ugcagucuau cagugcaaug ccucuaauga auauggauau     1320

uuacuggcaa acgcauuugu aaaugugcug gcugagccac cacgaauccu cacaccugca     1380

aacacacucu accaggucau ugcaaacagg ccugcuuuac uagacugugc cuucuuuggg     1440

ucuccucucc caaccaucga gugguuuaaa ggagcuaaag gaagugcucu ucaugaagau     1500

auuuauguuu uacaugaaaa uggaacuuug gaaauuccug uggcccaaaa ggacaguaca     1560

ggaacuuaua cguguguugc aaggaauaaa uuagggaugg cgaagaauga aguucacuua     1620

gaaaucaaag auccuacaug gaucguuaaa cagcccgaau augcaguugu gcaaagaggg     1680

agcauggugu ccuuugaaug caaagugaaa caugaucaca ccuuaucccu cacuguccug     1740

uggcugaagg acaacaggga acugcccagu gaugaaaggu ucacuguuga caaggaucau     1800

cuagugguag cugaugucag ugacgaugac agcgggaccu acacgugugu ggccaacacc     1860

acucuggaca gcgucuccgc cagcgcugug cuuagcguug uugcuccuac uccaacucca     1920

gcucccguuu acgauguccc aaauccuccc uuugacuuag aacugacaga ucaacuugac     1980

aaaaguguuc agcugucaug gaccccaggc gaugacaaca auagccccau uacaaaauuc     2040

aucaucgaau augaagaugc aaugcacaag ccagggcugu ggcaccacca aacugaaguu     2100

ucuggaacac agaccacagc ccagcugaag cugucuccuu acgugaacua cuccuuccgc     2160

gugauggcag ugaacagcau ugggaagagc uugcccagcg aggcgucuga gcaguauuug     2220

acgaaagccu cagaaccaga uaaaaacccc acagcugugg aaggacuggg aucagagccu     2280

gauaauuugg ugauuacgug gaagcccuug aaugguuucg aaucuaaugg gccaggccuu     2340

caguacaaag uuagcuggcg ccagaaagau ggugaugaug aauggacauc ugugguugug     2400

gcaaauguau ccaaauauau ugucucaggc acgccaaccu uuguuccaua ccugaucaaa     2460

guucaggccc ugaaugacau gggguuugcc cccgagccag cuguagucau gggacauucu     2520

ggagaagacc ucccaauggu ggcuccuggg aacgugcgug ugaauguggu gaacaguacc     2580

uuagccgagg ugcacuggga cccaguaccu cugaaaagca uccgaggaca ccuacaaggc     2640

uaucggauuu acuauuggaa gacccagagu ucaucuaaaa gaaacagacg ucacauugag     2700

aaaaagaucc ucaccuucca aggcagcaag acucauggca uguugccggg gcuagagccc     2760

uuuagccacu acacacugaa uguccgagug gucaauggga aaggggaggg cccagccagc     2820

ccugacagag ucuuuaauac uccagaagga guccccagug cucccucguc uuugaagauu     2880

gugaauccaa cacuggacuc ucucacuuug gaaugggauc caccgagcca cccgaauggc     2940

auuuugacag aguacaccuu aaaguaucag ccaauuaaca gcacacauga auuaggcccu     3000

cugguagauu ugaaaauucc ugccaacaag acacggugga cuuuaaaaaa uuuaaauuuc     3060

agcacucgau auaaguuuua uuucuaugca caaacaucag caggaucagg aagucaaauu     3120

acagaggaag caguaacaac uguggaugaa gcugguauuc uuccaccuga uguaggugca     3180

ggcaaaguuc aagcaguaaa ucccaggauc agcaaucuua cugcugcagc ugcugagacc     3240

uaugccaaua ucaguuggga auaugaggga ccagagcaug ugaacuuuua uguugaauau     3300

gguguagcag gcagcaaaga agaauggaga aaagaaauug uaaaugguuc ucggagcuuc     3360

uuuggguuaa agggucuaau gccaggaaca gcauacaaag uucgaguugg ugcugugggg     3420

gacucugguu uugugaguuc agaggaugug uuugagacag gcccagcgau ggcaagccgg     3480

cagguggaua uugcaacuca gggcugguuc auuggucuga ugugugcugu ugcucuccuu     3540

aucuuaauuu ugcugauugu uugcuucauc agaagaaaca agggugguaa auauccaguu     3600

aaagaaaagg aagaugccca ugcugacccu gaaauccagc cuaugaagga agaugauggg     3660

acauuuggag aauacaguga ugcagaagac cacaagccuu ugaaaaaagg aagucgaacu     3720

ccuucagaca ggacugugaa aaaagaagau agugacgaca gccuaguuga cuauggagaa     3780

gggguuaaug gccaguucaa ugaggauggc uccuuuauug gacaauacag ugguaagaaa     3840

gagaaagagc cggcugaagg aaacgaaagc ucagaggcac cuucuccugu caacgccaug     3900

aauuccuuug uuuaa                                                      3915


<210>  2892
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NRCAM__Homo_sapiens__CCDS47686.1

<400>  2892
augcagcuga agaucaugcc caagaagaag cgccucagcg ccggccgggu gccgcugauc       60

cuguuccucu gccagaugau cuccgcccug gagguccccc uggaccccaa gcuccuggag      120

gaccuggugc agcccccgac caucacccag cagagcccca aggacuacau caucgacccc      180

cgcgagaaca ucgugaucca gugcgaggcg aaggggaagc ccccgcccuc cuucagcugg      240

acgcggaacg gcacccacuu cgacaucgac aaggaccccc ucgucaccau gaagcccggg      300

accggcacgc ugaucaucaa caucaugucc gaggggaagg ccgagaccua cgagggcgug      360

uaccagugca ccgcccgcaa cgagcggggc gccgccguga gcaacaacau cgucgugcgc      420

ccgucccgga gcccccugug gaccaaggag aagcucgagc ccaucacgcu gcaguccggg      480

cagagccugg ugcuccccug ccgcccgccc aucggccugc ccccgcccau caucuucugg      540

auggacaacu ccuuccagcg gcugccccag agcgagcgcg ucucccaggg gcucaacggc      600

gaccuguacu ucagcaacgu gcugcccgag gacacccggg aggacuacau cugcuacgcg      660

cgcuucaacc acacccagac cauccagcag aagcagccca ucuccgugaa ggucaucagc      720

guggacgagc ucaacgacac gaucgccgcc aaccuguccg acaccgaguu cuacggggcc      780

aagagcuccc gggagcgccc gcccaccuuc cugacccccg agggcaacgc gagcaacaag      840

gaggagcucc ggggcaacgu gcugagccug gagugcaucg ccgaggggcu ccccacgccg      900

aucaucuacu gggccaagga ggacggcaug cugcccaaga accgcaccgu cuacaagaac      960

uucgagaaga cccugcagau cauccacgug uccgaggccg acagcgggaa cuaccagugc     1020

aucgccaaga acgcgcucgg cgccauccac cacaccaucu ccgugcgggu caaggccgcc     1080

cccuacugga ucacggcccc gcagaaccug gugcugagcc ccggcgagga cgggacccuc     1140

aucugccgcg cgaacggcaa ccccaagccc cggaucuccu ggcugaccaa cggggugccg     1200

aucgagaucg cccccgacga ccccagccgc aagaucgacg gcgacaccau caucuucucc     1260

aacguccagg agcggagcuc cgccguguac cagugcaacg ccagcaacga guacggguac     1320

cugcucgcca acgcguucgu gaacguccug gccgagcccc cgcgcauccu gacgcccgcc     1380

aacacccucu accaggugau cgccaaccgc cccgcccugc uggacugcgc guucuucggc     1440

agcccccucc cgaccaucga gugguucaag ggcgccaagg ggagcgcccu gcacgaggac     1500

aucuacgucc ugcacgagaa cggcacccuc gagauccccg uggcccagaa ggacuccacg     1560

gggaccuaca cgugcguggc gcggaacaag cugggcaugg ccaagaacga gguccaccug     1620

gagaucaagg accccaccug gaucgugaag cagcccgagu acgccguggu ccagcgcggg     1680

agcauggugu ccuucgagug caaggugaag cacgaccaca cccucagccu gaccguccug     1740

uggcugaagg acaaccggga gcucccgucc gacgagcgcu ucaccgugga caaggaccac     1800

cugguggucg ccgacgugag cgacgacgac uccggcaccu acacgugcgu ggccaacacc     1860

acccuggaca gcgucagcgc guccgccgug cucagcgugg ucgcccccac ccccaccccc     1920

gccccggugu acgacgugcc caacccgccc uucgaccugg agcugacgga ccagcucgac     1980

aaguccgucc agcugagcug gacccccggc gacgacaaca acucccccau caccaaguuc     2040

aucaucgagu acgaggacgc caugcacaag cccgggcugu ggcaccacca gaccgaggug     2100

agcggcacgc agaccaccgc gcagcucaag cuguccccgu acgugaacua cagcuuccgg     2160

gucauggccg ugaacuccau cgggaagucc cugcccuccg aggccagcga gcaguaccuc     2220

accaaggccu ccgagcccga caagaacccc acggccgugg agggccuggg gagcgagccg     2280

gacaaccugg ucaucaccug gaagccccuc aacggcuucg aguccaacgg ccccgggcug     2340

caguacaagg ugagcuggcg ccagaaggac ggcgacgacg aguggaccuc cguggucgug     2400

gcgaacguga gcaaguacau cgucagcggg acccccacgu ucgugccgua ccugaucaag     2460

gugcaggccc ucaacgacau gggcuucgcc cccgagcccg ccgucgugau gggccacucc     2520

ggggaggacc ugcccauggu ggcgccgggc aacguccggg ugaacguggu caacagcacc     2580

cuggccgagg ugcacuggga ccccgugccc cucaagucca uccgcgggca ccuccagggc     2640

uaccggaucu acuacuggaa gacccagagc uccagcaagc gcaaccggcg ccacaucgag     2700

aagaagaucc ugaccuucca gggguccaag acgcacggca ugcugcccgg ccuggagccg     2760

uucagccacu acacccugaa cguccgggug gugaacggga agggcgaggg gcccgccucc     2820

cccgaccgcg ucuucaacac ccccgagggc gugccgagcg cccccuccag ccucaagauc     2880

gugaacccca cccuggacuc ccugacgcuc gagugggacc cgcccagcca ccccaacggg     2940

auccugaccg aguacacccu gaaguaccag cccaucaacu ccacccacga gcucggcccc     3000

cuggucgacc ugaagauccc ggccaacaag acgcggugga cccucaagaa ccugaacuuc     3060

agcacccgcu acaaguucua cuucuacgcg cagaccuccg ccggcagcgg gucccagauc     3120

acggaggagg ccgugaccac cgucgacgag gccggcaucc ugccgcccga cgugggggcc     3180

ggcaaggugc aggcggucaa cccccggauc agcaaccuca ccgccgccgc cgccgagacg     3240

uacgcgaaca ucagcuggga guacgagggg cccgagcacg ugaacuucua cguggaguac     3300

ggcgucgccg gcuccaagga ggaguggcgc aaggagaucg ugaacgggag ccgguccuuc     3360

uucggccuga aggggcugau gcccggcacc gccuacaagg ugcgcgucgg ggccgugggc     3420

gacagcggcu ucguguccag cgaggacguc uucgagaccg ggcccgcgau ggccucccgc     3480

cagguggaca ucgccaccca gggcugguuc aucgggcuca ugugcgccgu ggcccugcug     3540

auccucaucc ugcugaucgu cugcuucauc cggcgcaaca agggcggcaa guacccggug     3600

aaggagaagg aggacgcgca cgccgacccc gagauccagc ccaugaagga ggacgacggg     3660

acguucggcg aguacagcga cgccgaggac cacaagcccc ucaagaaggg gucccggacc     3720

ccgagcgacc gcaccgugaa gaaggaggac uccgacgaca gccuggucga cuacggcgag     3780

ggggugaacg gccaguucaa cgaggacggc uccuucaucg ggcaguacag cggcaagaag     3840

gagaaggagc ccgccgaggg gaacgagucc agcgaggccc ccucccccgu gaacgcgaug     3900

aacagcuucg ucuga                                                      3915


<210>  2893
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NRCAM__Homo_sapiens__CCDS47686.1

<400>  2893
augcagcuca agaucaugcc caagaagaag cgccucuccg ccggccgcgu cccccucauc       60

cucuuccucu gccagaugau cuccgcccuc gagguccccc ucgaccccaa gcuccucgag      120

gaccucgucc agccccccac caucacccag caguccccca aggacuacau caucgacccc      180

cgcgagaaca ucgucaucca gugcgaggcc aagggcaagc ccccccccuc cuucuccugg      240

acccgcaacg gcacccacuu cgacaucgac aaggaccccc ucgucaccau gaagcccggc      300

accggcaccc ucaucaucaa caucaugucc gagggcaagg ccgagaccua cgagggcguc      360

uaccagugca ccgcccgcaa cgagcgcggc gccgccgucu ccaacaacau cgucguccgc      420

cccucccgcu ccccccucug gaccaaggag aagcucgagc ccaucacccu ccaguccggc      480

cagucccucg uccuccccug ccgccccccc aucggccucc ccccccccau caucuucugg      540

auggacaacu ccuuccagcg ccucccccag uccgagcgcg ucucccaggg ccucaacggc      600

gaccucuacu ucuccaacgu ccuccccgag gacacccgcg aggacuacau cugcuacgcc      660

cgcuucaacc acacccagac cauccagcag aagcagccca ucuccgucaa ggucaucucc      720

gucgacgagc ucaacgacac caucgccgcc aaccucuccg acaccgaguu cuacggcgcc      780

aaguccuccc gcgagcgccc ccccaccuuc cucacccccg agggcaacgc cuccaacaag      840

gaggagcucc gcggcaacgu ccucucccuc gagugcaucg ccgagggccu ccccaccccc      900

aucaucuacu gggccaagga ggacggcaug cuccccaaga accgcaccgu cuacaagaac      960

uucgagaaga cccuccagau cauccacguc uccgaggccg acuccggcaa cuaccagugc     1020

aucgccaaga acgcccucgg cgccauccac cacaccaucu ccguccgcgu caaggccgcc     1080

cccuacugga ucaccgcccc ccagaaccuc guccucuccc ccggcgagga cggcacccuc     1140

aucugccgcg ccaacggcaa ccccaagccc cgcaucuccu ggcucaccaa cggcgucccc     1200

aucgagaucg cccccgacga ccccucccgc aagaucgacg gcgacaccau caucuucucc     1260

aacguccagg agcgcuccuc cgccgucuac cagugcaacg ccuccaacga guacggcuac     1320

cuccucgcca acgccuucgu caacguccuc gccgagcccc cccgcauccu cacccccgcc     1380

aacacccucu accaggucau cgccaaccgc cccgcccucc ucgacugcgc cuucuucggc     1440

uccccccucc ccaccaucga gugguucaag ggcgccaagg gcuccgcccu ccacgaggac     1500

aucuacgucc uccacgagaa cggcacccuc gagauccccg ucgcccagaa ggacuccacc     1560

ggcaccuaca ccugcgucgc ccgcaacaag cucggcaugg ccaagaacga gguccaccuc     1620

gagaucaagg accccaccug gaucgucaag cagcccgagu acgccgucgu ccagcgcggc     1680

uccauggucu ccuucgagug caaggucaag cacgaccaca cccucucccu caccguccuc     1740

uggcucaagg acaaccgcga gcuccccucc gacgagcgcu ucaccgucga caaggaccac     1800

cucgucgucg ccgacgucuc cgacgacgac uccggcaccu acaccugcgu cgccaacacc     1860

acccucgacu ccgucuccgc cuccgccguc cucuccgucg ucgcccccac ccccaccccc     1920

gcccccgucu acgacguccc caaccccccc uucgaccucg agcucaccga ccagcucgac     1980

aaguccgucc agcucuccug gacccccggc gacgacaaca acucccccau caccaaguuc     2040

aucaucgagu acgaggacgc caugcacaag cccggccucu ggcaccacca gaccgagguc     2100

uccggcaccc agaccaccgc ccagcucaag cucucccccu acgucaacua cuccuuccgc     2160

gucauggccg ucaacuccau cggcaagucc cuccccuccg aggccuccga gcaguaccuc     2220

accaaggccu ccgagcccga caagaacccc accgccgucg agggccucgg cuccgagccc     2280

gacaaccucg ucaucaccug gaagccccuc aacggcuucg aguccaacgg ccccggccuc     2340

caguacaagg ucuccuggcg ccagaaggac ggcgacgacg aguggaccuc cgucgucguc     2400

gccaacgucu ccaaguacau cgucuccggc acccccaccu ucguccccua ccucaucaag     2460

guccaggccc ucaacgacau gggcuucgcc cccgagcccg ccgucgucau gggccacucc     2520

ggcgaggacc uccccauggu cgcccccggc aacguccgcg ucaacgucgu caacuccacc     2580

cucgccgagg uccacuggga ccccgucccc cucaagucca uccgcggcca ccuccagggc     2640

uaccgcaucu acuacuggaa gacccagucc uccuccaagc gcaaccgccg ccacaucgag     2700

aagaagaucc ucaccuucca gggcuccaag acccacggca ugcuccccgg ccucgagccc     2760

uucucccacu acacccucaa cguccgcguc gucaacggca agggcgaggg ccccgccucc     2820

cccgaccgcg ucuucaacac ccccgagggc guccccuccg cccccuccuc ccucaagauc     2880

gucaacccca cccucgacuc ccucacccuc gagugggacc cccccuccca ccccaacggc     2940

auccucaccg aguacacccu caaguaccag cccaucaacu ccacccacga gcucggcccc     3000

cucgucgacc ucaagauccc cgccaacaag acccgcugga cccucaagaa ccucaacuuc     3060

uccacccgcu acaaguucua cuucuacgcc cagaccuccg ccggcuccgg cucccagauc     3120

accgaggagg ccgucaccac cgucgacgag gccggcaucc ucccccccga cgucggcgcc     3180

ggcaaggucc aggccgucaa cccccgcauc uccaaccuca ccgccgccgc cgccgagacc     3240

uacgccaaca ucuccuggga guacgagggc cccgagcacg ucaacuucua cgucgaguac     3300

ggcgucgccg gcuccaagga ggaguggcgc aaggagaucg ucaacggcuc ccgcuccuuc     3360

uucggccuca agggccucau gcccggcacc gccuacaagg uccgcgucgg cgccgucggc     3420

gacuccggcu ucgucuccuc cgaggacguc uucgagaccg gccccgccau ggccucccgc     3480

caggucgaca ucgccaccca gggcugguuc aucggccuca ugugcgccgu cgcccuccuc     3540

auccucaucc uccucaucgu cugcuucauc cgccgcaaca agggcggcaa guaccccguc     3600

aaggagaagg aggacgccca cgccgacccc gagauccagc ccaugaagga ggacgacggc     3660

accuucggcg aguacuccga cgccgaggac cacaagcccc ucaagaaggg cucccgcacc     3720

cccuccgacc gcaccgucaa gaaggaggac uccgacgacu cccucgucga cuacggcgag     3780

ggcgucaacg gccaguucaa cgaggacggc uccuucaucg gccaguacuc cggcaagaag     3840

gagaaggagc ccgccgaggg caacgagucc uccgaggccc ccucccccgu caacgccaug     3900

aacuccuucg ucuga                                                      3915


<210>  2894
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NRCAM__Homo_sapiens__CCDS47686.1

<400>  2894
augcagcuga agaucaugcc caaaaagaaa agacucagcg ccggcagggu gccucuuauu       60

cuguucuugu gccaaaugau auccgcuuua gaggucccac uggacccgaa gcuacucgaa      120

gaucugguuc agcccccuac caucacacag cagucuccaa aagacuacau uaucgauccc      180

cgggagaaua uugugaucca augugaagca aaggggaagc cuccacccuc auuuaguugg      240

acucgcaaug gaacgcacuu cgacauagau aaagacccuc uuguaaccau gaagccaggu      300

acaggcacuc ugaucauuaa caucaugagc gaggggaaag ccgaaaccua ugagggagug      360

uaccagugca cagcgcgaaa ugagcguggc gcugccgucu ccaacaauau ugugguuaga      420

ccgucuaggu cgcccuugug gaccaaggaa aaacucgagc cuaucacucu gcagucaggu      480

cagagccugg ugcucccaug ucggcccccu auaggguuac cacccccgau uaucuuuugg      540

auggauaaca guuuccaacg ccugccucag uccgaaagag ucucucaggg acuuaauggc      600

gacuuguauu uuagcaacgu gcugcccgag gauacaaggg aggacuacau uugcuaugca      660

cgguucaauc auacccagac gauccaacag aagcagccaa ucuccguaaa gguuauuuca      720

guggaugaac uaaacgacac uauagccgcu aaucucagug auaccgaguu uuacggcgca      780

aaaagcucuc gcgaacgacc ucccacauuc cugacuccag aggggaacgc cuccaauaag      840

gaggaacuua gaggaaacgu ccugucauug gaguguaucg cugaaggucu ccccaccccu      900

auuaucuauu gggccaaaga ggacggcaug cugccaaaga auaggacagu guacaaaaac      960

uuugaaaaga ccuuacaaau aauucacgug agcgaggcgg acagugggaa cuaccagugc     1020

aucgcuaaaa augcccuggg agcuauccau cacacgauuu cuguccgggu uaaggccgca     1080

ccguauugga ucacugcucc ccagaaccuc gugcuuuccc cuggcgaaga ugguacacug     1140

auuugucgug ccaaugggaa cccaaagccc cgcauaagcu gguugaccaa uggaguaccu     1200

aucgagauug cgccagacga ucccucgaga aaaaucgacg gcgauacuau cauuuucucu     1260

aacgugcagg agagguccuc agccgucuac caaugcaaug caaguaacga auauggcuac     1320

cuacuggcua augccuuugu gaacguucuc gcugagccgc cucggauacu gacaccagcc     1380

aauacccuuu aucaggugau cgcaaaccga cccgcccugu uggacugugc uuucuuuggg     1440

agcccucucc ccacgauuga augguucaag ggagcgaaag guuccgcacu gcaugaggau     1500

aucuacgucu uacacgaaaa uggcacccug gagauuccag uggcccagaa ggacucuaca     1560

gggacuuaua ccugcguagc ucgcaacaaa cuaggaaugg ccaagaauga gguucaccuc     1620

gaaaucaagg auccuacaug gauagugaaa cagcccgagu acgcagucgu gcaaagaggc     1680

agcauggucu cauucgaaug uaaggugaaa caugaccaca cucugagucu uaccguuuug     1740

uggcugaagg auaacaggga gcucccaucc gacgagcggu uuacagugga caaagaucau     1800

cugguagucg ccgacgugag cgaugacgau ucugguaccu acacuugcgu ugcuaacacg     1860

acacuugacu cagugagugc cagcgcaguc cuguccgugg uagcgccgac cccuacuccc     1920

gcuccagugu augauguucc caauccucca uucgacuugg aacucaccga ucagcuggac     1980

aagucugucc aguuaucgug gacacccggg gaugacaaca auagcccuau caccaaguuu     2040

auuaucgagu acgaagaugc caugcacaaa ccgggccugu ggcaccauca gacugaggug     2100

uccggaacac aaacgaccgc acagcuaaag cucucaccau augugaacua caguuuccgc     2160

gucauggccg uuaauucuau uggcaaaagc cugcccuccg aagcaucaga gcaguaucuu     2220

acuaaggcca gcgagccuga caaaaaccca acagcagugg aaggguuggg aucugagccc     2280

gacaaucugg ugaucaccug gaagccucuc aacgguuuug aauccaaugg cccggggcug     2340

caguacaagg uaaguuggag acaaaaagau ggagacgaug aguggacaag cgucgugguu     2400

gcuaacgugu cuaaguauau agucuccggc acucccaccu ucgugccaua cuuaauuaaa     2460

guucaggccc ugaaugacau ggguuuugcg ccugaacccg ccgugguaau ggggcacuca     2520

ggcgaggauc uuccaauggu cgcuccugga aacgugaggg ugaaugucgu uaacaguacg     2580

uuggcagagg ugcauuggga ccccguacca cucaagagca uccguggcca ucugcagggg     2640

uaccggauuu auuacuggaa aacccaaucg uccucuaagc gaaauagaag gcacaucgaa     2700

aagaagauac uaacauucca gggaagcaag acucacggua ugcugccggg ccucgagccu     2760

uuuucacacu auacccugaa cgugcgcguc gugaacggga aaggagaagg ccccgccagu     2820

ccagaucggg uuuucaauac acccgagggu gugccuuccg cuccaucuag ccuuaagauc     2880

gucaacccca cuuuggacuc ccugaccuua gaaugggauc cuccgucaca uccaaauggg     2940

auucucacgg aguacacacu gaaauaucag cccaucaaca gcacccacga gcuuggcccu     3000

cugguggacu ugaagauucc cgccaauaaa acuagaugga cacucaagaa ccugaauuuu     3060

aguaccaggu acaaguucua uuuuuacgca cagacuucug cgggauccgg cagccaaauc     3120

accgaagagg ccguuacaac gguggaugaa gcugggauac uaccaccuga cgucggagcc     3180

ggcaaaguac aggcagugaa cccccgcauu ucgaaucuga ccgcugccgc agccgagacu     3240

uacgcuaaca ucucauggga guaugaaggu ccagagcaug uuaauuucua cguggaauau     3300

ggggucgcgg gaucuaagga ggaauggcga aaagagaucg ugaacggcag ucgguccuuc     3360

uuuggucuca agggccugau gccugggaca gccuacaaag uacguguggg agcagucggc     3420

gauagcgggu ucguuucuag cgaggacgug uuugaaaccg gaccggcuau ggccuccaga     3480

cagguggaca uugccacaca gggcugguuc aucggucuua ugugcgcugu cgcauugcug     3540

auuuuaauac uccugaucgu guguuuuauu aggcgcaaua aagggggaaa guaucccguu     3600

aaagagaagg aagaugccca cgcggaccca gagauccaac cuaugaaaga agaugacggc     3660

acuuucggug aguacucaga ugcugaggac cacaagcccc uuaaaaaggg cagucggacc     3720

ccaagcgaua gaacgguaaa gaaagaagac ucugaugacu cccuggugga uuauggggag     3780

ggagucaacg gccaguuuaa ugaagacggg ucauucauug gacaguacag uggcaagaaa     3840

gagaaggaac cugccgaggg uaacgagagc uccgaagcac ccucuccggu gaacgccaug     3900

aacucguuug uuuga                                                      3915


<210>  2895
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NRCAM__Homo_sapiens__CCDS47686.1

<400>  2895
augcagcuga agaucaugcc caagaagaag agacugagcg ccggcagagu gccccugauc       60

cuguuccugu gccagaugau cagcgcccug gaggugcccc uggaccccaa gcugcuggag      120

gaccuggugc agccccccac caucacccag cagagcccca aggacuacau caucgacccc      180

agagagaaca ucgugaucca gugcgaggcc aagggcaagc ccccccccag cuucagcugg      240

accagaaacg gcacccacuu cgacaucgac aaggaccccc uggugaccau gaagcccggc      300

accggcaccc ugaucaucaa caucaugagc gagggcaagg ccgagaccua cgagggcgug      360

uaccagugca ccgccagaaa cgagagaggc gccgccguga gcaacaacau cguggugaga      420

cccagcagaa gcccccugug gaccaaggag aagcuggagc ccaucacccu gcagagcggc      480

cagagccugg ugcugcccug cagacccccc aucggccugc ccccccccau caucuucugg      540

auggacaaca gcuuccagag acugccccag agcgagagag ugagccaggg ccugaacggc      600

gaccuguacu ucagcaacgu gcugcccgag gacaccagag aggacuacau cugcuacgcc      660

agauucaacc acacccagac cauccagcag aagcagccca ucagcgugaa ggugaucagc      720

guggacgagc ugaacgacac caucgccgcc aaccugagcg acaccgaguu cuacggcgcc      780

aagagcagca gagagagacc ccccaccuuc cugacccccg agggcaacgc cagcaacaag      840

gaggagcuga gaggcaacgu gcugagccug gagugcaucg ccgagggccu gcccaccccc      900

aucaucuacu gggccaagga ggacggcaug cugcccaaga acagaaccgu guacaagaac      960

uucgagaaga cccugcagau cauccacgug agcgaggccg acagcggcaa cuaccagugc     1020

aucgccaaga acgcccuggg cgccauccac cacaccauca gcgugagagu gaaggccgcc     1080

cccuacugga ucaccgcccc ccagaaccug gugcugagcc ccggcgagga cggcacccug     1140

aucugcagag ccaacggcaa ccccaagccc agaaucagcu ggcugaccaa cggcgugccc     1200

aucgagaucg cccccgacga ccccagcaga aagaucgacg gcgacaccau caucuucagc     1260

aacgugcagg agagaagcag cgccguguac cagugcaacg ccagcaacga guacggcuac     1320

cugcuggcca acgccuucgu gaacgugcug gccgagcccc ccagaauccu gacccccgcc     1380

aacacccugu accaggugau cgccaacaga cccgcccugc uggacugcgc cuucuucggc     1440

agcccccugc ccaccaucga gugguucaag ggcgccaagg gcagcgcccu gcacgaggac     1500

aucuacgugc ugcacgagaa cggcacccug gagauccccg uggcccagaa ggacagcacc     1560

ggcaccuaca ccugcguggc cagaaacaag cugggcaugg ccaagaacga ggugcaccug     1620

gagaucaagg accccaccug gaucgugaag cagcccgagu acgccguggu gcagagaggc     1680

agcaugguga gcuucgagug caaggugaag cacgaccaca cccugagccu gaccgugcug     1740

uggcugaagg acaacagaga gcugcccagc gacgagagau ucaccgugga caaggaccac     1800

cugguggugg ccgacgugag cgacgacgac agcggcaccu acaccugcgu ggccaacacc     1860

acccuggaca gcgugagcgc cagcgccgug cugagcgugg uggcccccac ccccaccccc     1920

gcccccgugu acgacgugcc caaccccccc uucgaccugg agcugaccga ccagcuggac     1980

aagagcgugc agcugagcug gacccccggc gacgacaaca acagccccau caccaaguuc     2040

aucaucgagu acgaggacgc caugcacaag cccggccugu ggcaccacca gaccgaggug     2100

agcggcaccc agaccaccgc ccagcugaag cugagccccu acgugaacua cagcuucaga     2160

gugauggccg ugaacagcau cggcaagagc cugcccagcg aggccagcga gcaguaccug     2220

accaaggcca gcgagcccga caagaacccc accgccgugg agggccuggg cagcgagccc     2280

gacaaccugg ugaucaccug gaagccccug aacggcuucg agagcaacgg ccccggccug     2340

caguacaagg ugagcuggag acagaaggac ggcgacgacg aguggaccag cgugguggug     2400

gccaacguga gcaaguacau cgugagcggc acccccaccu ucgugcccua ccugaucaag     2460

gugcaggccc ugaacgacau gggcuucgcc cccgagcccg ccguggugau gggccacagc     2520

ggcgaggacc ugcccauggu ggcccccggc aacgugagag ugaacguggu gaacagcacc     2580

cuggccgagg ugcacuggga ccccgugccc cugaagagca ucagaggcca ccugcagggc     2640

uacagaaucu acuacuggaa gacccagagc agcagcaaga gaaacagaag acacaucgag     2700

aagaagaucc ugaccuucca gggcagcaag acccacggca ugcugcccgg ccuggagccc     2760

uucagccacu acacccugaa cgugagagug gugaacggca agggcgaggg ccccgccagc     2820

cccgacagag uguucaacac ccccgagggc gugcccagcg cccccagcag ccugaagauc     2880

gugaacccca cccuggacag ccugacccug gagugggacc cccccagcca ccccaacggc     2940

auccugaccg aguacacccu gaaguaccag cccaucaaca gcacccacga gcugggcccc     3000

cugguggacc ugaagauccc cgccaacaag accagaugga cccugaagaa ccugaacuuc     3060

agcaccagau acaaguucua cuucuacgcc cagaccagcg ccggcagcgg cagccagauc     3120

accgaggagg ccgugaccac cguggacgag gccggcaucc ugccccccga cgugggcgcc     3180

ggcaaggugc aggccgugaa ccccagaauc agcaaccuga ccgccgccgc cgccgagacc     3240

uacgccaaca ucagcuggga guacgagggc cccgagcacg ugaacuucua cguggaguac     3300

ggcguggccg gcagcaagga ggaguggaga aaggagaucg ugaacggcag cagaagcuuc     3360

uucggccuga agggccugau gcccggcacc gccuacaagg ugagaguggg cgccgugggc     3420

gacagcggcu ucgugagcag cgaggacgug uucgagaccg gccccgccau ggccagcaga     3480

cagguggaca ucgccaccca gggcugguuc aucggccuga ugugcgccgu ggcccugcug     3540

auccugaucc ugcugaucgu gugcuucauc agaagaaaca agggcggcaa guaccccgug     3600

aaggagaagg aggacgccca cgccgacccc gagauccagc ccaugaagga ggacgacggc     3660

accuucggcg aguacagcga cgccgaggac cacaagcccc ugaagaaggg cagcagaacc     3720

cccagcgaca gaaccgugaa gaaggaggac agcgacgaca gccuggugga cuacggcgag     3780

ggcgugaacg gccaguucaa cgaggacggc agcuucaucg gccaguacag cggcaagaag     3840

gagaaggagc ccgccgaggg caacgagagc agcgaggccc ccagccccgu gaacgccaug     3900

aacagcuucg uguga                                                      3915


<210>  2896
<211>  3915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NRCAM__Homo_sapiens__CCDS47686.1

<400>  2896
augcagcuga agaucaugcc caaaaagaaa agacucagcg ccggccgggu gccucugauu       60

cuuuuccugu gccaaaugau cuccgcucuc gaggucccgc uggaccccaa acuucuggaa      120

gaucucguuc agccucccac cauuacacag cagucuccua aagacuacau cauugauccc      180

cgcgagaaca ucgugaucca augugaagcc aaggggaagc cuccgcccag cuuuuccugg      240

acgagaaaug gaacccacuu cgacauugau aaagacccuc uggugacaau gaagcccggc      300

accgggacac ugaucauuaa caucaugucu gagggaaaag cggaaaccua ugagggcguc      360

uaccagugca cagcucggaa ugagcgcggg gccgccguga gcaacaauau uguugugaga      420

ccuucccggu cuccccucug gaccaaggaa aaacuggagc cgaucacgcu ucagagcgga      480

cagucccugg uccucccuug uagacccccu auuggccugc ccccucccau caucuuuugg      540

auggauaaca gcuuccaacg ccuuccgcag ucugaacggg ugucccaggg ccugaauggg      600

gaccucuauu uuagcaacgu ucugcccgag gauacccgcg aggacuacau uugcuaugcu      660

agauucaauc auacacagac cauccaacag aagcagccua uuucugugaa ggucaucucc      720

guggaugaac ugaacgacac aauugccgcu aaucucagcg auaccgaguu uuacggagcc      780

aaaucuuccc gggaaagacc cccuacguuc cugacacccg agggcaacgc gagcaauaag      840

gaggaacuuc gcgggaacgu gcugucccuc gaguguaucg ccgaaggacu gccgaccccu      900

aucauuuauu gggcuaaaga ggacggcaug cuucccaaga aucggacagu cuacaaaaac      960

uuugaaaaga cccugcaaau cauucacguu ucugaggccg acagcgggaa cuaccagugc     1020

aucgcuaaaa augcccucgg agcgauucau cacaccaucu ccgugcgcgu gaaggccgcu     1080

ccuuauugga ucacagcucc ccagaaccug guccugagcc cuggcgaaga uggcacgcuc     1140

auuuguagag cuaaugggaa ccccaagccg cggaucucuu ggcugaccaa uggagugccu     1200

auugagaucg cccccgacga ucccuccaga aaaauugacg gcgauacaau cauuuucagc     1260

aacguucagg agcgcucuag cgccguguac caaugcaaug cuuccaacga auauggguac     1320

cuucuggcga augccuuugu caacgugcuc gcugagccuc cgcggauccu gacccccgcc     1380

aauacacuuu aucagguuau cgccaacaga ccugcucugc ucgacugugc cuucuuugga     1440

ucuccccugc cuaccauuga augguucaag ggcgcgaaag ggagcgcucu gcaugaggau     1500

aucuacgugc uccacgaaaa uggaacgcug gagauucccg ucgcccagaa ggacuccaca     1560

ggcaccuaua ccugcguggc ccgcaacaaa cuuggcaugg cuaagaauga gguccaccug     1620

gaaaucaagg auccuacaug gauugugaaa cagcccgagu acgccguugu gcaacggggg     1680

agcauggucu cuuucgaaug uaaggugaaa caugaccaca cccucucccu gacaguucug     1740

uggcuuaagg auaacagaga gcucccgagc gacgagcgcu uuacggugga caaagaucau     1800

cuggucgugg cugacguguc ugaugacgau uccggaaccu acacaugcgu ugccaacacc     1860

acacuggaca gcgucuccgc gucugccgug cucagcgugg ucgcuccuac ccccacgccu     1920

gcccccgugu augauguucc gaauccuccc uucgaccugg aacuuaccga ucagcuggac     1980

aaguccgugc agcucucuug gacaccuggc gaugacaaca auagccccau caccaaguuu     2040

aucauugagu acgaagaugc uaugcacaaa cccgggcugu ggcaccauca gacagagguc     2100

uccggaaccc aaacgacagc ccagcugaaa cuuagcccuu augugaacua cucuuuccgg     2160

guuauggcgg ucaauuccau cggcaagagc cucccgucug aagccuccga gcaguaucug     2220

accaaggcua gcgagcccga caaaaacccu acagccgugg aagggcuggg cucugagccc     2280

gacaaucucg ugauuaccug gaagccucug aacggauuug aaagcaaugg ccccgggcuu     2340

caguacaagg uuuccuggag acaaaaagau ggagacgaug aguggaccag cguggucgug     2400

gcuaacgugu cuaaguauau cgucuccggc acaccuacgu ucguuccgua ccugauuaaa     2460

gugcaggccc ucaaugacau gggguuugcc cccgaaccug cuguggucau gggacacagc     2520

ggcgaggauc ugcccauggu ggcgccuggg aacguucgcg ugaaugucgu gaacuccacc     2580

cuggccgagg uucauuggga ccccgugccg cuuaagucua uccggggcca ccuccaggga     2640

uacagaaucu auuacuggaa aacacaaagc uccucuaagc gcaaucggag acauauugaa     2700

aagaagaucc ugaccuucca gggcagcaag acacacggga ugcugccugg acucgagccc     2760

uuuucccacu auacccugaa cguccgggug guuaacggca aaggggaagg acccgcuucu     2820

ccugaucgcg uguucaauac gcccgagggc gucccuagcg ccccguccag ccuuaagauu     2880

gugaacccca cacuggacuc ucucacccug gaaugggauc cucccuccca uccuaauggg     2940

auccugaccg aguacacacu uaaauaucag cccauuaaca gcacccacga gcucggcccg     3000

cugguggacc ugaagauccc ugccaauaaa acaagaugga cgcucaagaa ccugaauuuu     3060

ucuacccggu acaaguucua uuuuuacgcu cagacauccg ccggaagcgg cucucaaauc     3120

accgaagagg cggucacaac cguugaugaa gcugggauuc uucccccuga cgugggagcc     3180

ggcaaagugc aggccgucaa ccccagaauc uccaaucuga cggcugccgc ggcugagacc     3240

uacgccaaca uuagcuggga guaugaaggg ccugagcaug ugaauuucua cguugaauau     3300

ggaguggccg gcuccaagga ggaauggcgc aaagagaucg ucaacgggag ccggucuuuc     3360

uuuggccuca agggacugau gcccggcaca gcuuacaaag ugagaguugg ggccguggga     3420

gauagcggcu ucgucuccuc ugaggacgug uuugaaaccg ggccggcuau ggccagccgc     3480

caggucgaca uugcgacaca gggaugguuc aucggccuga ugugcgccgu ggcccuucug     3540

auucucaucc ugcucaucgu uuguuuuauu agacggaaua agggcgggaa guauccugug     3600

aaagagaagg aagaugccca cgcugacccc gagauccaac ccaugaaaga agaugacgga     3660

accuucggcg aguacuccga ugccgaggac cacaagccuc ugaaaaaggg gucucgcaca     3720

ccgagcgaua gaaccgucaa gaaagaagac uccgaugacu cucuugugga uuauggagag     3780

ggcguuaacg ggcaguuuaa ugaagacggc agcuucauug gacaguacuc cggcaagaaa     3840

gagaaggaac ccgccgaggg gaacgagagc ucugaagcuc cuucccccgu gaacgcgaug     3900

aauagcuuug ucuga                                                      3915


<210>  2897
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NSE__Homo_sapiens__P09104

<400>  2897

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  2898
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NSE__Homo_sapiens__AAB51320

<400>  2898
auguccauag agaagaucug ggcccgggag auccuggacu cccgcgggaa ccccacagug       60

gagguggauc ucuauacugc caaaggucuu uuccgggcug cagugcccag uggagccucu      120

acgggcaucu augaggcccu ggagcugagg gauggagaca aacagcguua cuuaggcaaa      180

gguguccuga aggcagugga ccacaucaac uccaccaucg cgccagcccu caucagcuca      240

ggucucucug ugguggagca agagaaacug gacaaccuga ugcuggaguu ggaugggacu      300

gagaacaaau ccaaguuugg ggccaaugcc auccugggug ugucucuggc cguguguaag      360

gcaggggcag cugagcggga acugccccug uaucgccaca uugcucagcu ggccgggaac      420

ucagaccuca uccugccugu gccggccuuc aacgugauca augguggcuc ucaugcuggc      480

aacaagcugg ccaugcagga guucaugauc cucccagugg gagcugagag cuuucgggau      540

gccaugcgac uaggugcaga ggucuaccau acacucaagg gagucaucaa ggacaaauac      600

ggcaaggaug ccaccaaugu gggggaugaa gguggcuuug cccccaauau ccuggagaac      660

agugaagccu uggagcuggu gaaggaagcc aucgacaagg cuggcuacac ggaaaagauc      720

guuauuggca uggauguugc ugccucagag uuuuaucgug auggcaaaua ugacuuggac      780

uucaagucuc ccacugaucc uucccgauac aucacugggg accagcuggg ggcacucuac      840

caggacuuug ucagggacua uccugugguc uccauugagg acccauuuga ccaggaugau      900

ugggcugccu gguccaaguu cacagccaau guagggaucc agauuguggg ugaugaccug      960

acagugacca acccaaaacg uauugagcgg gcaguggaag aaaaggccug caacugucug     1020

cugcucaagg ucaaccagau cggcucgguc acugaagcca uccaagcgug caagcuggcc     1080

caggagaaug gcuggggggu cauggugagu caucgcucag gagagacuga ggacacauuc     1140

auugcugacc uggugguggg gcugugcaca ggccagauca agacuggugc cccgugccgu     1200

ucugaacguc uggcuaaaua caaccagcuc augagaauug aggaagagcu gggggaugaa     1260

gcucgcuuug ccggacauaa cuuccguaau cccagugugc uguga                     1305


<210>  2899
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NSE__Homo_sapiens__AAB51320

<400>  2899
augagcaucg agaagaucug ggcccgcgag auccuggacu cccggggcaa ccccaccgug       60

gaggucgacc ucuacaccgc caaggggcug uuccgcgcgg ccgugccgag cggcgccucc      120

acggggaucu acgaggcccu ggagcuccgg gacggcgaca agcagcgcua ccuggggaag      180

ggcgugcuga aggccgucga ccacaucaac agcaccaucg cgcccgcccu caucuccagc      240

ggccuguccg ugguggagca ggagaagcug gacaaccuca ugcuggagcu ggacgggacc      300

gagaacaaga gcaaguucgg cgccaacgcc auccucgggg ucucccuggc ggugugcaag      360

gccggcgccg ccgagcggga gcugccccuc uaccgccaca ucgcccagcu ggcggggaac      420

agcgaccuga uccuccccgu gccggccuuc aacgucauca acggcggcuc ccacgccggg      480

aacaagcugg ccaugcagga guucaugauc cugcccgugg gcgccgagag cuuccgggac      540

gcgaugcgcc ucggggccga gguguaccac acccugaagg gcgucaucaa ggacaaguac      600

ggcaaggacg ccacgaacgu gggggacgag ggcggguucg cccccaacau ccuggagaac      660

uccgaggccc ucgagcuggu gaaggaggcg aucgacaagg ccggcuacac cgagaagauc      720

gucaucggga uggacguggc cgccagcgag uucuaccggg acggcaagua cgaccuggac      780

uucaaguccc ccaccgaccc gagccgcuac aucaccggcg accagcucgg ggcccuguac      840

caggacuucg ugcgggacua ccccgucgug uccaucgagg accccuucga ccaggacgac      900

ugggcggccu ggagcaaguu cacggccaac gugggcaucc agaucgucgg ggacgaccug      960

accgugacca accccaagcg caucgagcgg gccguggagg agaaggcgug caacugccuc     1020

cugcugaagg ucaaccagau cggcuccgug accgaggcca uccaggccug caagcucgcc     1080

caggagaacg gguggggcgu cauggugagc caccgcagcg gcgagacgga ggacaccuuc     1140

aucgccgacc ugguggucgg gcugugcacc ggccagauca agaccggggc gccgugccgg     1200

uccgagcgcc ucgccaagua caaccagcug augcggaucg aggaggagcu gggcgacgag     1260

gcccgcuucg ccgggcacaa cuuccggaac cccagcgugc ucuga                     1305


<210>  2900
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NSE__Homo_sapiens__AAB51320

<400>  2900
auguccaucg agaagaucug ggcccgcgag auccucgacu cccgcggcaa ccccaccguc       60

gaggucgacc ucuacaccgc caagggccuc uuccgcgccg ccguccccuc cggcgccucc      120

accggcaucu acgaggcccu cgagcuccgc gacggcgaca agcagcgcua ccucggcaag      180

ggcguccuca aggccgucga ccacaucaac uccaccaucg cccccgcccu caucuccucc      240

ggccucuccg ucgucgagca ggagaagcuc gacaaccuca ugcucgagcu cgacggcacc      300

gagaacaagu ccaaguucgg cgccaacgcc auccucggcg ucucccucgc cgucugcaag      360

gccggcgccg ccgagcgcga gcucccccuc uaccgccaca ucgcccagcu cgccggcaac      420

uccgaccuca uccuccccgu ccccgccuuc aacgucauca acggcggcuc ccacgccggc      480

aacaagcucg ccaugcagga guucaugauc cuccccgucg gcgccgaguc cuuccgcgac      540

gccaugcgcc ucggcgccga ggucuaccac acccucaagg gcgucaucaa ggacaaguac      600

ggcaaggacg ccaccaacgu cggcgacgag ggcggcuucg cccccaacau ccucgagaac      660

uccgaggccc ucgagcucgu caaggaggcc aucgacaagg ccggcuacac cgagaagauc      720

gucaucggca uggacgucgc cgccuccgag uucuaccgcg acggcaagua cgaccucgac      780

uucaaguccc ccaccgaccc cucccgcuac aucaccggcg accagcucgg cgcccucuac      840

caggacuucg uccgcgacua ccccgucguc uccaucgagg accccuucga ccaggacgac      900

ugggccgccu gguccaaguu caccgccaac gucggcaucc agaucgucgg cgacgaccuc      960

accgucacca accccaagcg caucgagcgc gccgucgagg agaaggccug caacugccuc     1020

cuccucaagg ucaaccagau cggcuccguc accgaggcca uccaggccug caagcucgcc     1080

caggagaacg gcuggggcgu cauggucucc caccgcuccg gcgagaccga ggacaccuuc     1140

aucgccgacc ucgucgucgg ccucugcacc ggccagauca agaccggcgc ccccugccgc     1200

uccgagcgcc ucgccaagua caaccagcuc augcgcaucg aggaggagcu cggcgacgag     1260

gcccgcuucg ccggccacaa cuuccgcaac cccuccgucc ucuga                     1305


<210>  2901
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NSE__Homo_sapiens__AAB51320

<400>  2901
augagcaucg agaagauuug ggccagagaa auacuggacu ccaggggcaa ccccaccgug       60

gaggucgauc ucuacacagc uaaagggcuu uuccgggcag ccguuccuuc uggagcguca      120

acugguaucu augaagcucu ggaguugcgc gacggcgaua agcagcgaua cuuagggaaa      180

ggagugcuga aggccguaga ccacauuaau aguacgaucg caccagcccu aauuagcucc      240

ggccucucug uggucgaaca agagaaacug gauaaccuua ugcuggaguu ggacgguacc      300

gaaaauaagu cgaaguuugg ggcuaacgca auccucggag ugucacuggc cguuugcaaa      360

gcuggcgccg cggagcguga acugccgcuc uauagacaua uagcacaguu agccggcaau      420

agcgaucuga uccuucccgu gccugcuuuc aacgucauua augggggaag ucacgccggu      480

aacaaguugg caaugcagga guuuaugauc cugccagugg gcgcugaguc cuucagggac      540

gccaugcggc uaggggcgga aguauaccau acacucaaag gaguuauuaa ggauaaauau      600

ggcaaggacg ccacuaaugu gggugaugaa gggggauuug cacccaacau ccuggaaaau      660

ucugaggcuc uugaacuggu caaggaggcc auagacaaag cuggcuacac cgagaagauu      720

gugaucggca uggauguggc cgcaagcgag uucuaucgcg acgggaaaua cgacuuggau      780

uuuaaguccc cuacagaccc aucaagauac auuaccggag aucagcucgg ugcccuguau      840

caagacuucg ucagggauua ccccguugug aguaucgagg acccuuuuga ucaggacgau      900

ugggcugcgu ggagcaaauu cacugcaaac guaggcaucc agauuguggg ggacgauuua      960

acagucacca auccaaagcg gauagaacgc gccguggagg aaaaggcuug uaacugccug     1020

cuccuuaaag uuaaucagau cggaucugug acggaggcca uucaagcaug uaagcuggcc     1080

caggagaacg gcuggggugu cauggugucc caccgaucag gggaaacuga ggacaccuuu     1140

aucgcugacu ugguaguugg ccuaugcaca ggacagauaa aaacuggcgc cccguguaga     1200

agcgaaaggc uggcaaagua uaaccagcuc augcggauug aggaggaacu gggggaugag     1260

gcgcguuucg cuggacauaa uuuucgcaac cccagugugc uuuga                     1305


<210>  2902
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NSE__Homo_sapiens__AAB51320

<400>  2902
augagcaucg agaagaucug ggccagagag auccuggaca gcagaggcaa ccccaccgug       60

gagguggacc uguacaccgc caagggccug uucagagccg ccgugcccag cggcgccagc      120

accggcaucu acgaggcccu ggagcugaga gacggcgaca agcagagaua ccugggcaag      180

ggcgugcuga aggccgugga ccacaucaac agcaccaucg cccccgcccu gaucagcagc      240

ggccugagcg ugguggagca ggagaagcug gacaaccuga ugcuggagcu ggacggcacc      300

gagaacaaga gcaaguucgg cgccaacgcc auccugggcg ugagccuggc cgugugcaag      360

gccggcgccg ccgagagaga gcugccccug uacagacaca ucgcccagcu ggccggcaac      420

agcgaccuga uccugcccgu gcccgccuuc aacgugauca acggcggcag ccacgccggc      480

aacaagcugg ccaugcagga guucaugauc cugcccgugg gcgccgagag cuucagagac      540

gccaugagac ugggcgccga gguguaccac acccugaagg gcgugaucaa ggacaaguac      600

ggcaaggacg ccaccaacgu gggcgacgag ggcggcuucg cccccaacau ccuggagaac      660

agcgaggccc uggagcuggu gaaggaggcc aucgacaagg ccggcuacac cgagaagauc      720

gugaucggca uggacguggc cgccagcgag uucuacagag acggcaagua cgaccuggac      780

uucaagagcc ccaccgaccc cagcagauac aucaccggcg accagcuggg cgcccuguac      840

caggacuucg ugagagacua ccccguggug agcaucgagg accccuucga ccaggacgac      900

ugggccgccu ggagcaaguu caccgccaac gugggcaucc agaucguggg cgacgaccug      960

accgugacca accccaagag aaucgagaga gccguggagg agaaggccug caacugccug     1020

cugcugaagg ugaaccagau cggcagcgug accgaggcca uccaggccug caagcuggcc     1080

caggagaacg gcuggggcgu gauggugagc cacagaagcg gcgagaccga ggacaccuuc     1140

aucgccgacc uggugguggg ccugugcacc ggccagauca agaccggcgc ccccugcaga     1200

agcgagagac uggccaagua caaccagcug augagaaucg aggaggagcu gggcgacgag     1260

gccagauucg ccggccacaa cuucagaaac cccagcgugc uguga                     1305


<210>  2903
<211>  1305
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NSE__Homo_sapiens__AAB51320

<400>  2903
augagcaucg agaagauuug ggccagagaa auccuggacu cccggggcaa ccccaccgug       60

gaggucgauc ucuacacagc uaaagggcug uuccgcgccg cgguuccuuc uggagcuagc      120

acgggcauuu augaagcccu ugagcugaga gacggggaua agcagcggua ccucggaaaa      180

ggcgugcuga aggccgugga ccacaucaau uccaccauug cuccggcccu uaucucuagc      240

gggcuguccg ucguggaaca agagaaacuc gauaaccuga ugcuggagcu cgacggaaca      300

gaaaauaagu cuaaguuugg cgcuaacgcc auccugggcg uuagccuugc ggugugcaaa      360

gccggggcug ccgagcgcga acugccccuc uauagacaua uugcucagcu ggccggaaau      420

uccgaucuua uccugccugu ccccgcguuc aacgugauua auggcgggag ccacgccgga      480

aacaagcucg cuaugcagga guuuaugauc cugccuguug gcgccgaguc uuuccgggac      540

gcuaugcgcc ugggggccga aguguaccau acccucaaag gagucauuaa ggauaaauau      600

ggcaaggacg ccacaaaugu gggcgaugag ggaggauuug cucccaacau ccuggaaaau      660

uccgaggcgc uugaacuggu gaaggaggcc auugacaaag cuggcuacac cgagaagauc      720

gucaucggga uggauguugc cgccagcgag uucuauagag acggaaaaua cgaccucgau      780

uuuaagucuc cuacagaccc gucccgguac auuaccggcg aucagcuggg ggcucuuuau      840

caagacuucg ugcgcgauua ccccgugguc agcaucgagg acccuuuuga ucaggacgau      900

ugggccgcgu ggucuaaauu cacggcuaac guggggauuc agaucguugg cgacgaucug      960

accgugacaa aucccaagag aauugaacgg gccgucgagg aaaaagccug uaacugccuc     1020

cugcugaagg ugaaucagau cggcuccguu accgaggcua uccaagccug uaagcucgcu     1080

caggagaacg gguggggagu gauggucagc caccgcuccg gcgaaacaga ggacaccuuu     1140

auugccgacc ugguggucgg gcuuugcacg ggacagauca aaacaggcgc gccuuguaga     1200

ucugaacggc uggccaagua uaaccagcuc augcgcauug aggaagaacu gggggaugag     1260

gcuagauucg ccggccauaa uuuucggaac cccagcgugc uuuga                     1305


<210>  2904
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NUF2__Homo_sapiens__Q9BZD4

<400>  2904

Met Glu Thr Leu Ser Phe Pro Arg Tyr Asn Val Ala Glu Ile Val Ile 
1               5                   10                  15      


His Ile Arg Asn Lys Ile Leu Thr Gly Ala Asp Gly Lys Asn Leu Thr 
            20                  25                  30          


Lys Asn Asp Leu Tyr Pro Asn Pro Lys Pro Glu Val Leu His Met Ile 
        35                  40                  45              


Tyr Met Arg Ala Leu Gln Ile Val Tyr Gly Ile Arg Leu Glu His Phe 
    50                  55                  60                  


Tyr Met Met Pro Val Asn Ser Glu Val Met Tyr Pro His Leu Met Glu 
65                  70                  75                  80  


Gly Phe Leu Pro Phe Ser Asn Leu Val Thr His Leu Asp Ser Phe Leu 
                85                  90                  95      


Pro Ile Cys Arg Val Asn Asp Phe Glu Thr Ala Asp Ile Leu Cys Pro 
            100                 105                 110         


Lys Ala Lys Arg Thr Ser Arg Phe Leu Ser Gly Ile Ile Asn Phe Ile 
        115                 120                 125             


His Phe Arg Glu Ala Cys Arg Glu Thr Tyr Met Glu Phe Leu Trp Gln 
    130                 135                 140                 


Tyr Lys Ser Ser Ala Asp Lys Met Gln Gln Leu Asn Ala Ala His Gln 
145                 150                 155                 160 


Glu Ala Leu Met Lys Leu Glu Arg Leu Asp Ser Val Pro Val Glu Glu 
                165                 170                 175     


Gln Glu Glu Phe Lys Gln Leu Ser Asp Gly Ile Gln Glu Leu Gln Gln 
            180                 185                 190         


Ser Leu Asn Gln Asp Phe His Gln Lys Thr Ile Val Leu Gln Glu Gly 
        195                 200                 205             


Asn Ser Gln Lys Lys Ser Asn Ile Ser Glu Lys Thr Lys Arg Leu Asn 
    210                 215                 220                 


Glu Leu Lys Leu Ser Val Val Ser Leu Lys Glu Ile Gln Glu Ser Leu 
225                 230                 235                 240 


Lys Thr Lys Ile Val Asp Ser Pro Glu Lys Leu Lys Asn Tyr Lys Glu 
                245                 250                 255     


Lys Met Lys Asp Thr Val Gln Lys Leu Lys Asn Ala Arg Gln Glu Val 
            260                 265                 270         


Val Glu Lys Tyr Glu Ile Tyr Gly Asp Ser Val Asp Cys Leu Pro Ser 
        275                 280                 285             


Cys Gln Leu Glu Val Gln Leu Tyr Gln Lys Lys Ile Gln Asp Leu Ser 
    290                 295                 300                 


Asp Asn Arg Glu Lys Leu Ala Ser Ile Leu Lys Glu Ser Leu Asn Leu 
305                 310                 315                 320 


Glu Asp Gln Ile Glu Ser Asp Glu Ser Glu Leu Lys Lys Leu Lys Thr 
                325                 330                 335     


Glu Glu Asn Ser Phe Lys Arg Leu Met Ile Val Lys Lys Glu Lys Leu 
            340                 345                 350         


Ala Thr Ala Gln Phe Lys Ile Asn Lys Lys His Glu Asp Val Lys Gln 
        355                 360                 365             


Tyr Lys Arg Thr Val Ile Glu Asp Cys Asn Lys Val Gln Glu Lys Arg 
    370                 375                 380                 


Gly Ala Val Tyr Glu Arg Val Thr Thr Ile Asn Gln Glu Ile Gln Lys 
385                 390                 395                 400 


Ile Lys Leu Gly Ile Gln Gln Leu Lys Asp Ala Ala Glu Arg Glu Lys 
                405                 410                 415     


Leu Lys Ser Gln Glu Ile Phe Leu Asn Leu Lys Thr Ala Leu Glu Lys 
            420                 425                 430         


Tyr His Asp Gly Ile Glu Lys Ala Ala Glu Asp Ser Tyr Ala Lys Ile 
        435                 440                 445             


Asp Glu Lys Thr Ala Glu Leu Lys Arg Lys Met Phe Lys Met Ser Thr 
    450                 455                 460                 






<210>  2905
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NUF2__Homo_sapiens__AAH08489

<400>  2905
auggaaacuu ugucuuuccc cagauauaau guagcugaga uugugauuca uauucgcaau       60

aagaucuuaa caggagcuga ugguaaaaac cucaccaaga augaucuuua uccaaaucca      120

aagccugaag ucuugcacau gaucuacaug agagccuuac aaauaguaua uggaauucga      180

cuggaacauu uuuacaugau gccagugaac ucugaaguca uguauccaca uuuaauggaa      240

ggcuucuuac cauucagcaa uuuaguuacu caucuggacu cauuuuugcc uaucugccgg      300

gugaaugacu uugagacugc ugauauucua uguccaaaag caaaacggac aagucgguuu      360

uuaaguggca uuaucaacuu uauucacuuc agagaagcau gccgugaaac guauauggaa      420

uuucuuuggc aauauaaauc cucugcggac aaaaugcaac aguuaaacgc cgcacaccag      480

gaggcauuaa ugaaacugga gagacuugau ucuguuccag uugaagagca agaagaguuc      540

aagcagcuuu cagauggaau ucaggagcua caacaaucac uaaaucagga uuuucaucaa      600

aaaacgauag ugcugcaaga gggaaauucc caaaagaagu caaauauuuc agagaaaacc      660

aagcguuuga augaacuaaa auugucggug guuucuuuga aagaaauaca agagaguuug      720

aaaacaaaaa uuguggauuc uccagagaag uuaaagaauu auaaagaaaa aaugaaagau      780

acgguccaga agcuuaaaaa ugccagacaa gaaguggugg agaaauauga aaucuaugga      840

gacucaguug acugccugcc uucaugucag uuggaagugc aguuauauca aaagaaaaua      900

caggaccuuu cagauaauag ggaaaaauua gccaguaucu uaaaggagag ccugaacuug      960

gaggaccaaa uugagaguga ugagucagaa cugaagaaau ugaagacuga agaaaauucg     1020

uucaaaagac ugaugauugu gaagaaggaa aaacuugcca cagcacaauu caaaauaaau     1080

aagaagcaug aagauguuaa gcaauacaaa cgcacaguaa uugaggauug caauaaaguu     1140

caagaaaaaa gaggugcugu cuaugaacga guaaccacaa uuaaucaaga aauccaaaaa     1200

auuaaacuug gaauucaaca acuaaaagau gcugcugaaa gggagaaacu gaagucccag     1260

gaaauauuuc uaaacuugaa aacugcuuug gagaaauacc acgacgguau ugaaaaggca     1320

gcagaggacu ccuaugcuaa gauagaugag aagacagcug aacugaagag gaagauguuc     1380

aaaaugucaa ccuga                                                      1395


<210>  2906
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NUF2__Homo_sapiens__AAH08489

<400>  2906
auggagaccc ugagcuuccc ccgcuacaac guggccgaga ucgucaucca cauccggaac       60

aagauccuca ccggcgccga cgggaagaac cugacgaaga acgaccugua cccgaacccc      120

aagcccgagg ugcuccacau gaucuacaug cgcgcgcugc agaucgugua cggcauccgg      180

cuggagcacu ucuacaugau gcccgucaac uccgagguga uguacccgca ccucauggag      240

ggguuccugc ccuucagcaa ccuggugacc caccucgacu ccuuccugcc caucugccgc      300

gucaacgacu ucgagaccgc cgacauccug ugccccaagg ccaagcggac cagccgcuuc      360

cucuccggca ucaucaacuu cauccacuuc cgggaggccu gccgcgagac guacauggag      420

uuccuguggc aguacaagag cuccgccgac aagaugcagc agcugaacgc ggcccaccag      480

gaggcccuca ugaagcugga gcggcuggac agcgugccgg uggaggagca ggaggaguuc      540

aagcagcucu ccgacgggau ccaggagcug cagcagagcc ugaaccagga cuuccaccag      600

aagaccaucg uccuccagga gggcaacucc cagaagaagu ccaacaucag cgagaagacc      660

aagcgccuga acgagcugaa gcucagcgug gugucccuga aggagaucca ggagagccug      720

aagaccaaga ucgucgacuc ccccgagaag cucaagaacu acaaggagaa gaugaaggac      780

acggugcaga agcugaagaa cgcccggcag gagguggucg agaaguacga gaucuacggc      840

gacagcgugg acugccugcc cuccugccag cucgaggugc agcuguacca gaagaagauc      900

caggaccuga gcgacaaccg cgagaagcuc gcgagcaucc ugaaggaguc ccugaaccuc      960

gaggaccaga ucgagagcga cgaguccgag cugaagaagc ugaagaccga ggagaacagc     1020

uucaagcggc ucaugaucgu caagaaggag aagcuggcca ccgcccaguu caagaucaac     1080

aagaagcacg aggacgugaa gcaguacaag cgcaccguga ucgaggacug caacaagguc     1140

caggagaagc gcggggccgu guacgagcgg gugacgacca ucaaccagga gauccagaag     1200

aucaagcugg gcauccagca gcucaaggac gccgcggagc gggagaagcu gaagucccag     1260

gagaucuucc ugaaccucaa gaccgcccug gagaaguacc acgacgggau cgagaaggcc     1320

gccgaggaca gcuacgccaa gaucgacgag aagaccgcgg agcugaagcg caagauguuc     1380

aagaugucca cguga                                                      1395


<210>  2907
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NUF2__Homo_sapiens__AAH08489

<400>  2907
auggagaccc ucuccuuccc ccgcuacaac gucgccgaga ucgucaucca cauccgcaac       60

aagauccuca ccggcgccga cggcaagaac cucaccaaga acgaccucua ccccaacccc      120

aagcccgagg uccuccacau gaucuacaug cgcgcccucc agaucgucua cggcauccgc      180

cucgagcacu ucuacaugau gcccgucaac uccgagguca uguaccccca ccucauggag      240

ggcuuccucc ccuucuccaa ccucgucacc caccucgacu ccuuccuccc caucugccgc      300

gucaacgacu ucgagaccgc cgacauccuc ugccccaagg ccaagcgcac cucccgcuuc      360

cucuccggca ucaucaacuu cauccacuuc cgcgaggccu gccgcgagac cuacauggag      420

uuccucuggc aguacaaguc cuccgccgac aagaugcagc agcucaacgc cgcccaccag      480

gaggcccuca ugaagcucga gcgccucgac uccguccccg ucgaggagca ggaggaguuc      540

aagcagcucu ccgacggcau ccaggagcuc cagcaguccc ucaaccagga cuuccaccag      600

aagaccaucg uccuccagga gggcaacucc cagaagaagu ccaacaucuc cgagaagacc      660

aagcgccuca acgagcucaa gcucuccguc gucucccuca aggagaucca ggagucccuc      720

aagaccaaga ucgucgacuc ccccgagaag cucaagaacu acaaggagaa gaugaaggac      780

accguccaga agcucaagaa cgcccgccag gaggucgucg agaaguacga gaucuacggc      840

gacuccgucg acugccuccc cuccugccag cucgaggucc agcucuacca gaagaagauc      900

caggaccucu ccgacaaccg cgagaagcuc gccuccaucc ucaaggaguc ccucaaccuc      960

gaggaccaga ucgaguccga cgaguccgag cucaagaagc ucaagaccga ggagaacucc     1020

uucaagcgcc ucaugaucgu caagaaggag aagcucgcca ccgcccaguu caagaucaac     1080

aagaagcacg aggacgucaa gcaguacaag cgcaccguca ucgaggacug caacaagguc     1140

caggagaagc gcggcgccgu cuacgagcgc gucaccacca ucaaccagga gauccagaag     1200

aucaagcucg gcauccagca gcucaaggac gccgccgagc gcgagaagcu caagucccag     1260

gagaucuucc ucaaccucaa gaccgcccuc gagaaguacc acgacggcau cgagaaggcc     1320

gccgaggacu ccuacgccaa gaucgacgag aagaccgccg agcucaagcg caagauguuc     1380

aagaugucca ccuga                                                      1395


<210>  2908
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NUF2__Homo_sapiens__AAH08489

<400>  2908
auggagaccc ugagcuuccc cagauacaac guggccgaaa ucgucauuca cauaaggaau       60

aagauccuca caggcgcuga cgggaaaaac cuuacuaaga augaucugua uccuaaccca      120

aaaccggagg uuuugcauau gauuuacaug cgggcauuac agaucgugua ugguauucgc      180

cuggaacacu uuuacaugau gcccguaaau uccgagguga uguauccuca ucuaauggaa      240

ggauuccucc cauuuucuaa ccuggucacg caccuugacu cauuccugcc caucugccga      300

gugaaugauu uugagaccgc cgacauauug uguccuaagg cgaaacguac aaguagauuc      360

cucagcggca ucauuaacuu uauccauuuc agggaggcuu gccgggaaac uuacauggag      420

uuucuguggc aauauaaguc cucugccgau aagaugcagc agcugaaugc agcccaccag      480

gaagcucuca ugaaauuaga gcgccuggac ucgguuccag uggaggaaca agaggaguuc      540

aagcagcuuu cagaugggau ucaggaguug cagcaaagcc ugaaccagga cuuucaccag      600

aaaaccaucg uccuacagga aggaaauagu caaaagaaau ccaacauauc ugagaagaca      660

aagagacuca augagcugaa acuuagcgug guaucccuga aggaaauuca ggagucauug      720

aaaaccaaga ucguugauag ucccgaaaaa cucaagaacu acaaagagaa gaugaaggac      780

acugugcaga aacugaagaa ugcaaggcaa gaagucgugg agaaauacga gauuuauggc      840

gauagcgugg acuguuuacc uucuugccag cuggaagucc agcucuacca gaagaaaauc      900

caagaucuuu ccgacaaccg ggagaagcug gccucaaucu ugaaggaaag ccuaaaccug      960

gaggaccaga uugaaaguga ugagucugag cucaaaaagc ugaaaacaga agaaaauucc     1020

uucaagcgcc uuaugauagu uaaaaaggaa aagcuggcua ccgcccaguu uaaaaucaac     1080

aagaaacaug aggacgugaa gcaguauaaa cgaacgguaa uugaggauug uaauaaggug     1140

caagaaaaga gaggugcggu cuacgagagg gugacuacca ucaaccagga aauacagaaa     1200

auuaaguugg ggauccagca acucaaagac gcagccgagc gggaaaagcu gaaaagccag     1260

gagaucuucu uaaaucugaa gacagcucua gagaaauauc acgauggaau ugaaaaggcc     1320

gcagaggacu cguacgcuaa gaucgaugag aaaacugccg aacucaagcg uaaaauguuc     1380

aagaugucua ccuga                                                      1395


<210>  2909
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NUF2__Homo_sapiens__AAH08489

<400>  2909
auggagaccc ugagcuuccc cagauacaac guggccgaga ucgugaucca caucagaaac       60

aagauccuga ccggcgccga cggcaagaac cugaccaaga acgaccugua ccccaacccc      120

aagcccgagg ugcugcacau gaucuacaug agagcccugc agaucgugua cggcaucaga      180

cuggagcacu ucuacaugau gcccgugaac agcgagguga uguaccccca ccugauggag      240

ggcuuccugc ccuucagcaa ccuggugacc caccuggaca gcuuccugcc caucugcaga      300

gugaacgacu ucgagaccgc cgacauccug ugccccaagg ccaagagaac cagcagauuc      360

cugagcggca ucaucaacuu cauccacuuc agagaggccu gcagagagac cuacauggag      420

uuccuguggc aguacaagag cagcgccgac aagaugcagc agcugaacgc cgcccaccag      480

gaggcccuga ugaagcugga gagacuggac agcgugcccg uggaggagca ggaggaguuc      540

aagcagcuga gcgacggcau ccaggagcug cagcagagcc ugaaccagga cuuccaccag      600

aagaccaucg ugcugcagga gggcaacagc cagaagaaga gcaacaucag cgagaagacc      660

aagagacuga acgagcugaa gcugagcgug gugagccuga aggagaucca ggagagccug      720

aagaccaaga ucguggacag ccccgagaag cugaagaacu acaaggagaa gaugaaggac      780

accgugcaga agcugaagaa cgccagacag gagguggugg agaaguacga gaucuacggc      840

gacagcgugg acugccugcc cagcugccag cuggaggugc agcuguacca gaagaagauc      900

caggaccuga gcgacaacag agagaagcug gccagcaucc ugaaggagag ccugaaccug      960

gaggaccaga ucgagagcga cgagagcgag cugaagaagc ugaagaccga ggagaacagc     1020

uucaagagac ugaugaucgu gaagaaggag aagcuggcca ccgcccaguu caagaucaac     1080

aagaagcacg aggacgugaa gcaguacaag agaaccguga ucgaggacug caacaaggug     1140

caggagaaga gaggcgccgu guacgagaga gugaccacca ucaaccagga gauccagaag     1200

aucaagcugg gcauccagca gcugaaggac gccgccgaga gagagaagcu gaagagccag     1260

gagaucuucc ugaaccugaa gaccgcccug gagaaguacc acgacggcau cgagaaggcc     1320

gccgaggaca gcuacgccaa gaucgacgag aagaccgccg agcugaagag aaagauguuc     1380

aagaugagca ccuga                                                      1395


<210>  2910
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NUF2__Homo_sapiens__AAH08489

<400>  2910
auggagaccc ugagcuuccc cagauacaac guggccgaaa ucgucauuca cauccggaau       60

aagauucuca caggcgcuga cgggaaaaac cugacgaaga augaucuuua uccuaacccg      120

aaacccgagg uucugcauau gaucuacaug cgcgcccucc agauugugua uggaaucaga      180

cuggaacacu uuuacaugau gccugucaau uccgagguga uguaucccca ucuuauggaa      240

ggcuuccugc cuuuuucuaa ccucgugacc caccuggaca gcuuccugcc caucugccgg      300

guuaaugauu uugagacagc ggacauucuc uguccuaagg cuaaacgcac cuccagauuc      360

cugucuggga ucauuaacuu uauccauuuc cgggaggccu gccgcgaaac auacauggag      420

uuucuuuggc aauauaagag cuccgccgau aagaugcagc agcugaaugc ugcccaccag      480

gaagcucuca ugaaacugga gagacuugac ucugugccgg ucgaggaaca agaggaguuc      540

aagcagcuga gcgauggcau ucaggaacuc cagcaauccc ugaaccagga cuuucaccag      600

aaaaccaucg ugcugcagga aggaaauagc caaaagaaau cuaacauuuc cgagaagaca      660

aagcggcuca augagcugaa acuuagcguu gugucucuga aggaaaucca ggagucccuc      720

aaaaccaaga ucgucgauag ccccgaaaaa cugaagaacu acaaagagaa gaugaaggac      780

acggugcaga aacuuaagaa ugcccgccaa gaaguggucg agaaauacga gauuuauggg      840

gauucuguug acugucugcc uuccugccag cucgaagugc agcuguacca gaagaaaauc      900

caagaucuga gcgacaacag agagaagcuc gcguccauuc ugaaggaauc ucuuaaccug      960

gaggaccaga ucgaaagcga ugaguccgag cucaaaaagc ugaaaaccga agagaauagc     1020

uucaagcggc uuaugauugu gaaaaaggaa aagcuggcca cagcucaguu uaaaaucaac     1080

aagaaacaug aggacgucaa gcaguauaaa cgcaccguga ucgaggauug uaauaagguu     1140

caagaaaaga gaggagccgu guacgagcgg gucacaacca uuaaccagga aauccagaaa     1200

auuaagcucg gcauccagca acugaaagac gcugccgagc gcgaaaagcu gaaaucucag     1260

gagauuuucc ucaaucugaa gacggcgcuu gagaaauauc acgauggcau cgaaaaggcc     1320

gcugaggacu ccuacgccaa gaucgaugag aaaacagcug aacugaagag aaaaauguuc     1380

aagaugagca ccuga                                                      1395


<210>  2911
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NY-ESO-1__Homo_sapiens__P78358

<400>  2911

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  2912
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NY-ESO-1__Homo_sapiens__AAB49693

<400>  2912
augcaggccg aaggccgggg cacagggggu ucgacgggcg augcugaugg cccaggaggc       60

ccuggcauuc cugauggccc agggggcaau gcuggcggcc caggagaggc gggugccacg      120

ggcggcagag guccccgggg cgcaggggca gcaagggccu cggggccggg aggaggcgcc      180

ccgcgggguc cgcauggcgg cgcggcuuca gggcugaaug gaugcugcag augcggggcc      240

agggggccgg agagccgccu gcuugaguuc uaccucgcca ugccuuucgc gacacccaug      300

gaagcagagc uggcccgcag gagccuggcc caggaugccc caccgcuucc cgugccaggg      360

gugcuucuga aggaguucac uguguccggc aacauacuga cuauccgacu gacugcugca      420

gaccaccgcc aacugcagcu cuccaucagc uccugucucc agcagcuuuc ccuguugaug      480

uggaucacgc agugcuuucu gcccguguuu uuggcucagc cucccucagg gcagaggcgc      540

uaa                                                                    543


<210>  2913
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NY-ESO-1__Homo_sapiens__AAB49693

<400>  2913
augcaggccg agggccgcgg gaccggcggg agcaccggcg acgccgacgg gcccggcggc       60

ccggggaucc ccgacggccc cgggggcaac gccgggggcc ccggcgaggc cggggccacg      120

ggcgggcggg gcccgcgcgg cgccggggcc gcgcgggccu ccggccccgg gggcggggcg      180

ccccgcggcc cccacggcgg ggccgcgagc ggccugaacg ggugcugccg gugcggcgcc      240

cgcgggccgg agucccggcu ccuggaguuc uaccuggcca ugcccuucgc cacccccaug      300

gaggccgagc ucgcgcgccg gagccuggcc caggacgcgc ccccgcugcc cgugcccggc      360

guccuccuga aggaguucac cguguccggc aacauccuga ccauccgccu cacggccgcc      420

gaccaccggc agcugcagcu gagcaucucc agcugccucc agcagcuguc ccugcucaug      480

uggaucaccc agugcuuccu gcccguguuc cuggcccagc cgcccagcgg gcagcgccgg      540

uga                                                                    543


<210>  2914
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NY-ESO-1__Homo_sapiens__AAB49693

<400>  2914
augcaggccg agggccgcgg caccggcggc uccaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggccgcg gcccccgcgg cgccggcgcc gcccgcgccu ccggccccgg cggcggcgcc      180

ccccgcggcc cccacggcgg cgccgccucc ggccucaacg gcugcugccg cugcggcgcc      240

cgcggccccg agucccgccu ccucgaguuc uaccucgcca ugcccuucgc cacccccaug      300

gaggccgagc ucgcccgccg cucccucgcc caggacgccc ccccccuccc cguccccggc      360

guccuccuca aggaguucac cgucuccggc aacauccuca ccauccgccu caccgccgcc      420

gaccaccgcc agcuccagcu cuccaucucc uccugccucc agcagcucuc ccuccucaug      480

uggaucaccc agugcuuccu ccccgucuuc cucgcccagc cccccuccgg ccagcgccgc      540

uga                                                                    543


<210>  2915
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NY-ESO-1__Homo_sapiens__AAB49693

<400>  2915
augcaggccg agggcagagg gaccggaggu agcacaggcg acgcugaugg gcccggaggc       60

ccugguaucc cagacgggcc gggaggcaac gcaggcgggc ccggagaagc cggugcgacu      120

ggcgggaggg gaccucgggg cgcuggugcc gcacgcgccu ccgggccagg aggcggcgcu      180

ccccgagggc cucacggagg ugcagccucu ggccugaaug ggugcugucg uugcggagcu      240

agaggcccag agucaaggcu ccuugaguuc uaccuggcca ugcccuuugc gacgccuaug      300

gaagcagaau uggcccggcg caguuuagcu caagaugccc caccgcugcc cgugccuggu      360

guccuacuca aggaguucac cguuagcggg aacauucuga caauaagacu uacugcagcu      420

gaccauaggc agcugcaguu guccaucucu ucgugucucc agcaacuguc acugcucaug      480

uggauuaccc agugcuuuuu accaguguuc cuggcccagc ccccuagcgg ccagcggcgc      540

uga                                                                    543


<210>  2916
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NY-ESO-1__Homo_sapiens__AAB49693

<400>  2916
augcaggccg agggcagagg caccggcggc agcaccggcg acgccgacgg ccccggcggc       60

cccggcaucc ccgacggccc cggcggcaac gccggcggcc ccggcgaggc cggcgccacc      120

ggcggcagag gccccagagg cgccggcgcc gccagagcca gcggccccgg cggcggcgcc      180

cccagaggcc cccacggcgg cgccgccagc ggccugaacg gcugcugcag augcggcgcc      240

agaggccccg agagcagacu gcuggaguuc uaccuggcca ugcccuucgc cacccccaug      300

gaggccgagc uggccagaag aagccuggcc caggacgccc ccccccugcc cgugcccggc      360

gugcugcuga aggaguucac cgugagcggc aacauccuga ccaucagacu gaccgccgcc      420

gaccacagac agcugcagcu gagcaucagc agcugccugc agcagcugag ccugcugaug      480

uggaucaccc agugcuuccu gcccguguuc cuggcccagc cccccagcgg ccagagaaga      540

uga                                                                    543


<210>  2917
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NY-ESO-1__Homo_sapiens__AAB49693

<400>  2917
augcaggccg agggcagagg gaccggaggc agcacagggg acgcugaugg acccggcggg       60

ccuggaaucc cggacggccc cggcgggaac gccggaggcc cuggggaagc gggagcuacg      120

ggcgggcggg gaccccgcgg cgccggcgcc gcuagagccu ccgggccugg aggcggggcu      180

ccccggggac cucacggcgg ggccgcgucu ggacugaaug gcugcugucg cugcggcgcc      240

agagggccgg agagccggcu ccuggaguuc uaccuugcua ugcccuuugc caccccuaug      300

gaagcugaac uggcccgcag aucccucgcg caagaugcuc ccccucugcc cgugccggga      360

guccuucuga aggaguucac aguuucuggc aacauucuca ccauccggcu gacagccgcc      420

gaccaucgcc agcugcagcu cagcauuucc ucuugucugc agcaacuuag ccugcucaug      480

uggaucaccc agugcuuucu gccuguguuc cuugcucagc ccccuuccgg gcagagacgg      540

uga                                                                    543


<210>  2918
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OA1__Homo_sapiens__P51810

<400>  2918

Met Ala Ser Pro Arg Leu Gly Thr Phe Cys Cys Pro Thr Arg Asp Ala 
1               5                   10                  15      


Ala Thr Gln Leu Val Leu Ser Phe Gln Pro Arg Ala Phe His Ala Leu 
            20                  25                  30          


Cys Leu Gly Ser Gly Gly Leu Arg Leu Ala Leu Gly Leu Leu Gln Leu 
        35                  40                  45              


Leu Pro Gly Arg Arg Pro Ala Gly Pro Gly Ser Pro Ala Thr Ser Pro 
    50                  55                  60                  


Pro Ala Ser Val Arg Ile Leu Arg Ala Ala Ala Ala Cys Asp Leu Leu 
65                  70                  75                  80  


Gly Cys Leu Gly Met Val Ile Arg Ser Thr Val Trp Leu Gly Phe Pro 
                85                  90                  95      


Asn Phe Val Asp Ser Val Ser Asp Met Asn His Thr Glu Ile Trp Pro 
            100                 105                 110         


Ala Ala Phe Cys Val Gly Ser Ala Met Trp Ile Gln Leu Leu Tyr Ser 
        115                 120                 125             


Ala Cys Phe Trp Trp Leu Phe Cys Tyr Ala Val Asp Ala Tyr Leu Val 
    130                 135                 140                 


Ile Arg Arg Ser Ala Gly Leu Ser Thr Ile Leu Leu Tyr His Ile Met 
145                 150                 155                 160 


Ala Trp Gly Leu Ala Thr Leu Leu Cys Val Glu Gly Ala Ala Met Leu 
                165                 170                 175     


Tyr Tyr Pro Ser Val Ser Arg Cys Glu Arg Gly Leu Asp His Ala Ile 
            180                 185                 190         


Pro His Tyr Val Thr Met Tyr Leu Pro Leu Leu Leu Val Leu Val Ala 
        195                 200                 205             


Asn Pro Ile Leu Phe Gln Lys Thr Val Thr Ala Val Ala Ser Leu Leu 
    210                 215                 220                 


Lys Gly Arg Gln Gly Ile Tyr Thr Glu Asn Glu Arg Arg Met Gly Ala 
225                 230                 235                 240 


Val Ile Lys Ile Arg Phe Phe Lys Ile Met Leu Val Leu Ile Ile Cys 
                245                 250                 255     


Trp Leu Ser Asn Ile Ile Asn Glu Ser Leu Leu Phe Tyr Leu Glu Met 
            260                 265                 270         


Gln Thr Asp Ile Asn Gly Gly Ser Leu Lys Pro Val Arg Thr Ala Ala 
        275                 280                 285             


Lys Thr Thr Trp Phe Ile Met Gly Ile Leu Asn Pro Ala Gln Gly Phe 
    290                 295                 300                 


Leu Leu Ser Leu Ala Phe Tyr Gly Trp Thr Gly Cys Ser Leu Gly Phe 
305                 310                 315                 320 


Gln Ser Pro Arg Lys Glu Ile Gln Trp Glu Ser Leu Thr Thr Ser Ala 
                325                 330                 335     


Ala Glu Gly Ala His Pro Ser Pro Leu Met Pro His Glu Asn Pro Ala 
            340                 345                 350         


Ser Gly Lys Val Ser Gln Val Gly Gly Gln Thr Ser Asp Glu Ala Leu 
        355                 360                 365             


Ser Met Leu Ser Glu Gly Ser Asp Ala Ser Thr Ile Glu Ile His Thr 
    370                 375                 380                 


Ala Ser Glu Ser Cys Asn Lys Asn Glu Gly Asp Pro Ala Leu Pro Thr 
385                 390                 395                 400 


His Gly Asp Leu 
                


<210>  2919
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OA1__Homo_sapiens__CCDS14134.2

<400>  2919
auggccuccc cgcgccuagg gaccuucugc ugccccacgc gggacgcagc cacgcagcuc       60

gugcugagcu uccagccgcg ggccuuccac gcgcucugcc ugggcagcgg cgggcuccgc      120

uuggcgcugg gccuucugca gcugcugccc ggccgccggc ccgcgggccc cggguccccc      180

gcgacguccc cgccggccuc gguccgcauc cugcgcgcug ccgcugccug cgaccuucuc      240

ggcugccugg guauggugau ccgguccacc gugugguuag gauucccaaa uuuuguugac      300

agcgucucgg auaugaacca cacggaaauu uggccugcug cuuucugcgu ggggagugcg      360

auguggaucc agcuguugua cagugccugc uucugguggc uguuuugcua ugcaguggau      420

gcuuaucugg ugauccggag aucggcagga cugagcacca uccugcugua ucacaucaug      480

gcguggggcc uggccacccu gcucugugug gagggagccg ccaugcucua cuacccuucc      540

guguccaggu gugagcgggg ccuggaccac gccauccccc acuaugucac cauguaccug      600

ccccugcugc ugguucucgu ggcgaacccc auccuguucc aaaagacagu gacugcagug      660

gccucuuuac uuaaaggaag acaaggcauu uacacggaga acgagaggag gaugggagcc      720

gugaucaaga uccgauuuuu caaaaucaug cugguuuuaa uuauuuguug guugucgaau      780

aucaucaaug aaagccuuuu auucuaucuu gagaugcaaa cagauaucaa uggagguucu      840

uugaaaccug ucagaacugc agccaagacc acaugguuua uuaugggaau ccugaaucca      900

gcccagggau uucucuuguc uuuggccuuc uacggcugga caggaugcag ccuggguuuu      960

cagucuccca ggaaggagau ccagugggaa ucacugacca ccucggcugc ugagggggcu     1020

cacccauccc cacugaugcc ccaugaaaac ccugcuuccg ggaagguguc ucaagugggu     1080

gggcagacuu cugacgaagc ccugagcaug cugucugaag guucugaugc cagcacaauu     1140

gaaauucaca cugcaaguga auccugcaac aaaaaugagg gugacccugc ucucccaacc     1200

cauggagacc uauga                                                      1215


<210>  2920
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OA1__Homo_sapiens__CCDS14134.2

<400>  2920
auggccagcc cccgccuggg caccuucugc ugcccgaccc gggacgccgc gacgcagcuc       60

gugcuguccu uccagccccg cgccuuccac gcccugugcc ucgggagcgg cgggcugcgg      120

cuggcccucg gccugcugca gcuccugccc gggcgccggc ccgccggccc gggcuccccc      180

gcgaccagcc cgcccgccuc cguccgcauc cugcgggccg ccgcggccug cgaccuccug      240

gggugccugg gcauggugau ccgcagcacc guguggcucg gguuccccaa cuucgucgac      300

uccgugagcg acaugaacca caccgagauc uggcccgccg ccuucugcgu gggcuccgcc      360

auguggaucc agcugcugua cagcgcgugc uucugguggc uguucugcua cgccgucgac      420

gccuaccucg ugauccggcg cuccgccggg cugagcacga uccuccugua ccacaucaug      480

gccuggggcc uggcgacccu ccugugcgug gagggcgccg ccaugcugua cuaccccucc      540

gucagccggu gcgagcgcgg gcucgaccac gccauccccc acuacgugac cauguaccug      600

ccgcugcucc uggugcuggu cgccaacccc auccucuucc agaagaccgu gacggcggug      660

gccucccugc ugaagggccg gcaggggauc uacaccgaga acgagcgccg gaugggcgcc      720

gucaucaaga uccgcuucuu caagaucaug cucgugcuga ucaucugcug gcugagcaac      780

aucaucaacg agucccuccu guucuaccug gagaugcaga ccgacaucaa cggcgggagc      840

cucaagcccg ugcggaccgc cgccaagacg accugguuca ucaugggcau ccugaacccc      900

gcgcaggggu uccugcucuc ccuggccuuc uacggcugga ccgggugcag ccugggcuuc      960

cagagcccgc gcaaggagau ccagugggag ucccucacca cgagcgccgc cgagggcgcg     1020

caccccagcc cccugaugcc ccacgagaac ccggccuccg ggaaggucuc ccaggugggc     1080

gggcagacca gcgacgaggc ccuguccaug cugagcgagg gcuccgacgc cagcaccauc     1140

gagauccaca ccgccuccga gagcugcaac aagaacgagg gggaccccgc gcuccccacg     1200

cacggcgacc uguga                                                      1215


<210>  2921
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OA1__Homo_sapiens__CCDS14134.2

<400>  2921
auggccuccc cccgccucgg caccuucugc ugccccaccc gcgacgccgc cacccagcuc       60

guccucuccu uccagccccg cgccuuccac gcccucugcc ucggcuccgg cggccuccgc      120

cucgcccucg gccuccucca gcuccucccc ggccgccgcc ccgccggccc cggcuccccc      180

gccaccuccc cccccgccuc cguccgcauc cuccgcgccg ccgccgccug cgaccuccuc      240

ggcugccucg gcauggucau ccgcuccacc gucuggcucg gcuuccccaa cuucgucgac      300

uccgucuccg acaugaacca caccgagauc uggcccgccg ccuucugcgu cggcuccgcc      360

auguggaucc agcuccucua cuccgccugc uucugguggc ucuucugcua cgccgucgac      420

gccuaccucg ucauccgccg cuccgccggc cucuccacca uccuccucua ccacaucaug      480

gccuggggcc ucgccacccu ccucugcguc gagggcgccg ccaugcucua cuaccccucc      540

gucucccgcu gcgagcgcgg ccucgaccac gccauccccc acuacgucac cauguaccuc      600

ccccuccucc ucguccucgu cgccaacccc auccucuucc agaagaccgu caccgccguc      660

gccucccucc ucaagggccg ccagggcauc uacaccgaga acgagcgccg caugggcgcc      720

gucaucaaga uccgcuucuu caagaucaug cucguccuca ucaucugcug gcucuccaac      780

aucaucaacg agucccuccu cuucuaccuc gagaugcaga ccgacaucaa cggcggcucc      840

cucaagcccg uccgcaccgc cgccaagacc accugguuca ucaugggcau ccucaacccc      900

gcccagggcu uccuccucuc ccucgccuuc uacggcugga ccggcugcuc ccucggcuuc      960

cagucccccc gcaaggagau ccagugggag ucccucacca ccuccgccgc cgagggcgcc     1020

caccccuccc cccucaugcc ccacgagaac cccgccuccg gcaaggucuc ccaggucggc     1080

ggccagaccu ccgacgaggc ccucuccaug cucuccgagg gcuccgacgc cuccaccauc     1140

gagauccaca ccgccuccga guccugcaac aagaacgagg gcgaccccgc ccuccccacc     1200

cacggcgacc ucuga                                                      1215


<210>  2922
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OA1__Homo_sapiens__CCDS14134.2

<400>  2922
auggccagcc ccagacuggg caccuucugc uguccuacaa gggacgcugc aacucagcuc       60

gugcuuuccu uucaaccacg ggccuuccac gcgcugugcu uggggucugg agguuuacgc      120

cuggcucuag gccuccugca gcuucugccg gggcgacguc ccgccggacc uggcucacca      180

gcaacgaguc ccccugccag cgucagaauc uugagggcug cagccgcuug ugaucuccug      240

gguugccugg ggaugguuau ucgguccacc guguggcucg gauuuccaaa cuucguagac      300

ucugugucgg auaugaauca uacagagaua uggcccgccg cguuuugugu cggcucagca      360

auguggaucc aguuacugua cagcgccugc uucugguggu uguuuuguua ugcuguggac      420

gccuaccuug uuauucgcag aagugcaggc cuguccacua uccuacucua ucacauuaug      480

gcuugggggc uggccacccu ucugugcgug gaaggagcgg ccauguugua cuauccuucu      540

gucuccaggu gugagcgggg ucucgaucau gcaaucccac acuacgugac aauguaucug      600

ccguuacugc ucguacuugu ugcuaacccc auacuguucc agaagaccgu gacugccguc      660

gcuagcuugc uaaaaggccg ccaagggauc uacacagaaa augagcgaag aaugggagcc      720

gugauuaaga ucagguuuuu caaaauuaug cuggugcuca ucauaugcug gcugucaaac      780

auuaucaaug aaagucuucu guuuuacuug gagaugcaga ccgacauuaa cggcgguagc      840

cucaagccug uccggacggc agccaaaacu accugguuca ucauggggau ccugaaucca      900

gcucagggau uuuuacuguc ucuagcguuc uauggcugga caggcuguuc ccucggguuc      960

cagucacccc guaaggagau ucaaugggaa agccugacua ccagugcagc cgagggagcu     1020

cauccuucuc cacuuaugcc ccacgaaaac ccggccuccg guaagguuag ccaggugggc     1080

gggcagacau cggaugaggc auugucuaug cuguccgagg gaucagacgc caguaccaua     1140

gaaauccaca cggcuagcga guccugcaau aaaaacgaag gcgauccugc ccuccccacu     1200

cauggugacc uguga                                                      1215


<210>  2923
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OA1__Homo_sapiens__CCDS14134.2

<400>  2923
auggccagcc ccagacuggg caccuucugc ugccccacca gagacgccgc cacccagcug       60

gugcugagcu uccagcccag agccuuccac gcccugugcc ugggcagcgg cggccugaga      120

cuggcccugg gccugcugca gcugcugccc ggcagaagac ccgccggccc cggcagcccc      180

gccaccagcc cccccgccag cgugagaauc cugagagccg ccgccgccug cgaccugcug      240

ggcugccugg gcauggugau cagaagcacc guguggcugg gcuuccccaa cuucguggac      300

agcgugagcg acaugaacca caccgagauc uggcccgccg ccuucugcgu gggcagcgcc      360

auguggaucc agcugcugua cagcgccugc uucugguggc uguucugcua cgccguggac      420

gccuaccugg ugaucagaag aagcgccggc cugagcacca uccugcugua ccacaucaug      480

gccuggggcc uggccacccu gcugugcgug gagggcgccg ccaugcugua cuaccccagc      540

gugagcagau gcgagagagg ccuggaccac gccauccccc acuacgugac cauguaccug      600

ccccugcugc uggugcuggu ggccaacccc auccuguucc agaagaccgu gaccgccgug      660

gccagccugc ugaagggcag acagggcauc uacaccgaga acgagagaag aaugggcgcc      720

gugaucaaga ucagauucuu caagaucaug cuggugcuga ucaucugcug gcugagcaac      780

aucaucaacg agagccugcu guucuaccug gagaugcaga ccgacaucaa cggcggcagc      840

cugaagcccg ugagaaccgc cgccaagacc accugguuca ucaugggcau ccugaacccc      900

gcccagggcu uccugcugag ccuggccuuc uacggcugga ccggcugcag ccugggcuuc      960

cagagcccca gaaaggagau ccagugggag agccugacca ccagcgccgc cgagggcgcc     1020

caccccagcc cccugaugcc ccacgagaac cccgccagcg gcaaggugag ccaggugggc     1080

ggccagacca gcgacgaggc ccugagcaug cugagcgagg gcagcgacgc cagcaccauc     1140

gagauccaca ccgccagcga gagcugcaac aagaacgagg gcgaccccgc ccugcccacc     1200

cacggcgacc uguga                                                      1215


<210>  2924
<211>  1215
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OA1__Homo_sapiens__CCDS14134.2

<400>  2924
auggccagcc ccagacuggg caccuucugc uguccuacac gggacgcugc cacgcagcuc       60

gugcuguccu uucaaccgcg cgcguuccac gcucuuugcc uggggucugg aggccucaga      120

cuggcccuug ggcugcucca gcugcugccc ggacggcgcc cugccggccc cgggagcccu      180

gcuaccucuc ccccugccuc cgucagaauc cuccgggcug ccgcggccug ugaucugcuu      240

ggaugccugg gcaugguuau ucgcagcaca guguggcucg gcuuuccgaa cuucguggac      300

uccgucucug auaugaauca uaccgagauc uggcccgcug ccuuuugugu ggggagcgcu      360

auguggauuc agcugcuuua cuccgccugc uucugguggc uguuuuguua ugcgguugac      420

gccuaccucg ugaucagacg gagcgcugga cugucuacaa uucugcucua ucacaucaug      480

gccuggggcc uggcuacccu ucugugcguc gaaggggccg ccaugcucua cuauccuucc      540

gugagccgcu gugagagagg acuggaucau gcuauccccc acuacguuac aauguaucuu      600

ccucugcucc uggugcuggu cgcgaacccc auucucuucc agaagaccgu gacggccgug      660

gcuucucugc uuaaaggccg gcaagggauc uacaccgaaa augagcgcag aaugggagcc      720

gucauuaaga uccgguuuuu caaaauuaug cugguucuca ucauuugcug gcuguccaac      780

aucaucaaug aaagccuucu guuuuaccuc gagaugcaga cagacauuaa cggcggcucu      840

cugaagccgg ugcgcaccgc cgcuaaaaca accugguuca ucauggggau ucugaauccu      900

gcccagggau uucuccuguc ccuugcguuc uauggcugga cgggguguag ccugggauuc      960

caguccccca gaaaggagau ccaaugggaa ucucucacaa ccagcgcugc cgagggcgcc     1020

cauccuagcc cccugaugcc ccacgaaaac ccugcuuccg ggaagguguc ucaggucgga     1080

ggccagacau ccgaugaggc ccugagcaug cuuucugagg gcagcgacgc uuccaccauu     1140

gaaauccaca ccgccucuga gagcugcaau aaaaacgaag gggauccggc gcuccccaca     1200

cauggagacc uguga                                                      1215


<210>  2925
<211>  1046
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OGT__Homo_sapiens__O15294

<400>  2925

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Glu Pro Thr Lys 
1               5                   10                  15      


Arg Met Leu Ser Phe Gln Gly Leu Ala Glu Leu Ala His Arg Glu Tyr 
            20                  25                  30          


Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gln Leu Trp 
        35                  40                  45              


Arg Gln Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser Ile 
    50                  55                  60                  


His Phe Gln Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 
65                  70                  75                  80  


Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly 
                85                  90                  95      


Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln Glu Ala Ile Glu His Tyr 
            100                 105                 110         


Arg His Ala Leu Arg Leu Lys Pro Asp Phe Ile Asp Gly Tyr Ile Asn 
        115                 120                 125             


Leu Ala Ala Ala Leu Val Ala Ala Gly Asp Met Glu Gly Ala Val Gln 
    130                 135                 140                 


Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro Asp Leu Tyr Cys Val Arg 
145                 150                 155                 160 


Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu Gly Arg Leu Glu Glu Ala 
                165                 170                 175     


Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr Gln Pro Asn Phe Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Leu Gly Cys Val Phe Asn Ala Gln Gly Glu Ile Trp 
        195                 200                 205             


Leu Ala Ile His His Phe Glu Lys Ala Val Thr Leu Asp Pro Asn Phe 
    210                 215                 220                 


Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val Leu Lys Glu Ala Arg Ile 
225                 230                 235                 240 


Phe Asp Arg Ala Val Ala Ala Tyr Leu Arg Ala Leu Ser Leu Ser Pro 
                245                 250                 255     


Asn His Ala Val Val His Gly Asn Leu Ala Cys Val Tyr Tyr Glu Gln 
            260                 265                 270         


Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr Arg Arg Ala Ile Glu Leu 
        275                 280                 285             


Gln Pro His Phe Pro Asp Ala Tyr Cys Asn Leu Ala Asn Ala Leu Lys 
    290                 295                 300                 


Glu Lys Gly Ser Val Ala Glu Ala Glu Asp Cys Tyr Asn Thr Ala Leu 
305                 310                 315                 320 


Arg Leu Cys Pro Thr His Ala Asp Ser Leu Asn Asn Leu Ala Asn Ile 
                325                 330                 335     


Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala Val Arg Leu Tyr Arg Lys 
            340                 345                 350         


Ala Leu Glu Val Phe Pro Glu Phe Ala Ala Ala His Ser Asn Leu Ala 
        355                 360                 365             


Ser Val Leu Gln Gln Gln Gly Lys Leu Gln Glu Ala Leu Met His Tyr 
    370                 375                 380                 


Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe Ala Asp Ala Tyr Ser Asn 
385                 390                 395                 400 


Met Gly Asn Thr Leu Lys Glu Met Gln Asp Val Gln Gly Ala Leu Gln 
                405                 410                 415     


Cys Tyr Thr Arg Ala Ile Gln Ile Asn Pro Ala Phe Ala Asp Ala His 
            420                 425                 430         


Ser Asn Leu Ala Ser Ile His Lys Asp Ser Gly Asn Ile Pro Glu Ala 
        435                 440                 445             


Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu Lys Pro Asp Phe Pro Asp 
    450                 455                 460                 


Ala Tyr Cys Asn Leu Ala His Cys Leu Gln Ile Val Cys Asp Trp Thr 
465                 470                 475                 480 


Asp Tyr Asp Glu Arg Met Lys Lys Leu Val Ser Ile Val Ala Asp Gln 
                485                 490                 495     


Leu Glu Lys Asn Arg Leu Pro Ser Val His Pro His His Ser Met Leu 
            500                 505                 510         


Tyr Pro Leu Ser His Gly Phe Arg Lys Ala Ile Ala Glu Arg His Gly 
        515                 520                 525             


Asn Leu Cys Leu Asp Lys Ile Asn Val Leu His Lys Pro Pro Tyr Glu 
    530                 535                 540                 


His Pro Lys Asp Leu Lys Leu Ser Asp Gly Arg Leu Arg Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ser Asp Phe Gly Asn His Pro Thr Ser His Leu Met Gln Ser 
                565                 570                 575     


Ile Pro Gly Met His Asn Pro Asp Lys Phe Glu Val Phe Cys Tyr Ala 
            580                 585                 590         


Leu Ser Pro Asp Asp Gly Thr Asn Phe Arg Val Lys Val Met Ala Glu 
        595                 600                 605             


Ala Asn His Phe Ile Asp Leu Ser Gln Ile Pro Cys Asn Gly Lys Ala 
    610                 615                 620                 


Ala Asp Arg Ile His Gln Asp Gly Ile His Ile Leu Val Asn Met Asn 
625                 630                 635                 640 


Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu Phe Ala Leu Arg Pro Ala 
                645                 650                 655     


Pro Ile Gln Ala Met Trp Leu Gly Tyr Pro Gly Thr Ser Gly Ala Leu 
            660                 665                 670         


Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu Thr Ser Pro Ala Glu Val 
        675                 680                 685             


Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr Met Pro His Thr Phe Phe 
    690                 695                 700                 


Ile Gly Asp His Ala Asn Met Phe Pro His Leu Lys Lys Lys Ala Val 
705                 710                 715                 720 


Ile Asp Phe Lys Ser Asn Gly His Ile Tyr Asp Asn Arg Ile Val Leu 
                725                 730                 735     


Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp Ser Leu Pro Asp Val Lys 
            740                 745                 750         


Ile Val Lys Met Lys Cys Pro Asp Gly Gly Asp Asn Ala Asp Ser Ser 
        755                 760                 765             


Asn Thr Ala Leu Asn Met Pro Val Ile Pro Met Asn Thr Ile Ala Glu 
    770                 775                 780                 


Ala Val Ile Glu Met Ile Asn Arg Gly Gln Ile Gln Ile Thr Ile Asn 
785                 790                 795                 800 


Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr Thr Gln Ile Asn Asn Lys 
                805                 810                 815     


Ala Ala Thr Gly Glu Glu Val Pro Arg Thr Ile Ile Val Thr Thr Arg 
            820                 825                 830         


Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile Val Tyr Cys Asn Phe Asn 
        835                 840                 845             


Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu Gln Met Trp Ala Asn Ile 
    850                 855                 860                 


Leu Lys Arg Val Pro Asn Ser Val Leu Trp Leu Leu Arg Phe Pro Ala 
865                 870                 875                 880 


Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala Gln Asn Met Gly Leu Pro 
                885                 890                 895     


Gln Asn Arg Ile Ile Phe Ser Pro Val Ala Pro Lys Glu Glu His Val 
            900                 905                 910         


Arg Arg Gly Gln Leu Ala Asp Val Cys Leu Asp Thr Pro Leu Cys Asn 
        915                 920                 925             


Gly His Thr Thr Gly Met Asp Val Leu Trp Ala Gly Thr Pro Met Val 
    930                 935                 940                 


Thr Met Pro Gly Glu Thr Leu Ala Ser Arg Val Ala Ala Ser Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala Lys Asn Arg Gln Glu Tyr 
                965                 970                 975     


Glu Asp Ile Ala Val Lys Leu Gly Thr Asp Leu Glu Tyr Leu Lys Lys 
            980                 985                 990         


Val Arg Gly Lys Val Trp Lys Gln Arg Ile Ser Ser Pro Leu Phe Asn 
        995                 1000                1005            


Thr Lys Gln Tyr Thr Met Glu Leu Glu Arg Leu Tyr Leu Gln Met Trp 
    1010                1015                1020                


Glu His Tyr Ala Ala Gly Asn Lys Pro Asp His Met Ile Lys Pro Val 
1025                1030                1035                1040


Glu Val Thr Glu Ser Ala 
                1045    


<210>  2926
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OGT__Homo_sapiens__AAH38180

<400>  2926
auggcgucuu ccgugggcaa cguggccgac agcacagaac caacgaaacg uaugcuuucc       60

uuccaagggu uagcugaguu ggcacaucga gaauaucagg caggagauuu ugaggcagcu      120

gagagacacu gcaugcagcu cuggagacaa gagccagaca auacuggugu gcuuuuauua      180

cuuucaucua uacacuucca gugucgaagg cuggacagau cugcucacuu uagcacucug      240

gcaauuaaac agaacccccu ucuggcagaa gcuuauucga auuuggggaa uguguacaag      300

gaaagagggc aguugcagga ggcaauugag cauuaucgac augcauugcg ucucaaaccu      360

gauuucaucg augguuauau uaaccuggca gccgccuugg uagcagcggg ugacauggaa      420

ggggcaguac aagcuuacgu cucugcucuu caguacaauc cugauuugua cuguguucgc      480

agugaccugg ggaaccugcu caaagcccug ggucgcuugg aagaagccaa ggcauguuau      540

uugaaagcaa uugagacgca accgaacuuu gcaguagcuu ggaguaaucu uggcuguguu      600

uucaaugcac aaggggaaau uuggcuugca auucaucacu uugaaaaggc ugucacccuu      660

gacccaaacu uucuggaugc uuauaucaau uuaggaaaug ucuugaaaga ggcacgcauu      720

uuugacagag cuguggcagc uuaucuucgu gcccuaaguu ugaguccaaa ucacgcagug      780

gugcacggca accuggcuug uguauacuau gagcaaggcc ugauagaucu ggcaauagac      840

accuacaggc gggcuaucga acuacaacca cauuucccug augcuuacug caaccuagcc      900

aaugcucuca aagagaaggg caguguugcu gaagcagaag auuguuauaa uacagcucuc      960

cgucuguguc ccacccaugc agacucucug aauaaccuag ccaauaucaa acgagaacag     1020

ggaaacauug aagaggcagu ucgcuuguau cguaaagcau uagaagucuu cccagaguuu     1080

gcugcugccc auucaaauuu agcaagugua cugcagcagc agggaaaacu gcaggaagcu     1140

cugaugcauu auaaggaggc uauucgaauc aguccuaccu uugcugaugc cuacucuaau     1200

augggaaaca cucuaaagga gaugcaggau guucagggag ccuugcagug uuauacgcgu     1260

gccauccaaa uuaauccugc auuugcagau gcacauagca aucuggcuuc cauucauaag     1320

gauucaggga auauuccaga agccauagcu ucuuaccgca cggcucugaa acuuaagccu     1380

gauuuuccug augcuuauug uaacuuggcu cauugccugc agauugucug ugauuggaca     1440

gacuaugaug agcgaaugaa gaaguugguc aguauugugg cugaccaguu agagaagaau     1500

agguugccuu cugugcaucc ucaucauagu augcuauauc cucuuucuca uggcuucagg     1560

aaggcuauug cugagaggca cggcaaccug ugcuuagaua agauuaaugu ucuucauaaa     1620

ccaccauaug aacauccaaa agacuugaag cucagugaug gucggcugcg uguaggauau     1680

gugaguuccg acuuugggaa ucauccuacu ucucaccuua ugcagucuau uccaggcaug     1740

cacaauccug auaaauuuga gguguucugu uaugcccuga gcccagacga uggcacaaac     1800

uuccgaguga aggugauggc agaagccaau cauuucauug aucuuucuca gauuccaugc     1860

aauggaaaag cagcugaucg cauccaucag gauggaauuc auauccuugu aaauaugaau     1920

ggcuauacua agggcgcucg aaaugagcuu uuugcucuca ggccagcucc uauucaggca     1980

auguggcugg gauacccugg gacgaguggu gcgcuuuuca uggauuauau uaucacugau     2040

caggaaacuu cgccagcuga aguugcugag caguauuccg agaaauuggc uuauaugccc     2100

cacacuuuuu uuauugguga ucaugcuaau auguucccuc accugaagaa aaaagcaguc     2160

aucgauuuua aguccaaugg gcacauuuau gacaaucgga uaguucugaa uggcaucgac     2220

cucaaagcau uucuugauag ucuaccagau gugaaaauug ucaagaugaa guguccugau     2280

ggaggagaca augcagauag caguaacaca gcucuuaaua ugccuguuau uccuaugaau     2340

acuauugcag aagcaguuau ugaaaugauu aaccgaggac agauucaaau aacaauuaau     2400

ggauucagua uuagcaaugg acuggcaacu acucagauca acaauaaggc ugcaacugga     2460

gaggagguuc cccguaccau uauuguaacc acccguucuc aguacggguu accagaagau     2520

gccaucguau acuguaacuu uaaucaguug uauaaaauug acccuucuac uuugcagaug     2580

ugggcaaaca uucugaagcg uguucccaau aguguacucu ggcuguugcg uuuuccagca     2640

guaggagaac cuaauauuca acaguaugca caaaacaugg gccugcccca gaaccguauc     2700

auuuuuucac cuguugcucc uaaagaggaa cacgucagga gaggccagcu ggcugauguc     2760

ugcuuggaca cuccacucug uaaugggcac accacaggga uggauguccu cugggcaggg     2820

acccccaugg ugacuaugcc aggagagacu cuugcuucuc gaguugcagc aucccagcuc     2880

acuugcuuag guugucuuga gcuuauugcu aaaaacagac aagaauauga agacauagcu     2940

gugaagcugg gaacugaucu agaauaccug aagaaaguuc guggcaaagu cuggaagcaa     3000

agaauaucua gcccucuguu caacaccaaa caauacacaa uggaacuaga gcggcucuau     3060

cuacagaugu gggagcauua ugcagcuggc aacaaaccug accacaugau uaagccuguu     3120

gaagucacug agucagcaua a                                               3141


<210>  2927
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OGT__Homo_sapiens__AAH38180

<400>  2927
auggccagcu ccgugggcaa cgucgccgac agcaccgagc ccaccaagcg caugcugucc       60

uuccaggggc ucgcggagcu ggcccaccgg gaguaccagg ccggcgacuu cgaggccgcc      120

gagcgccacu gcaugcagcu guggcggcag gagccggaca acacgggggu gcuccugcug      180

cucagcucca uccacuucca gugccgccgg cuggaccgca gcgcgcacuu cuccacccug      240

gccaucaagc agaacccccu ccuggccgag gccuacagca accugggcaa cguguacaag      300

gagcgggggc agcuccagga ggcgaucgag cacuaccgcc acgcccugcg gcugaagccc      360

gacuucaucg acggcuacau caaccucgcc gccgcccugg ucgcggccgg cgacauggag      420

ggggccgugc aggccuacgu guccgcccug caguacaacc ccgaccucua cugcguccgc      480

agcgaccugg gcaaccugcu caaggcgcug gggcggcugg aggaggccaa ggccugcuac      540

cucaaggcca ucgagaccca gccgaacuuc gccguggcgu gguccaaccu gggcugcgug      600

uucaacgccc agggggagau cuggcuggcc auccaccacu ucgagaaggc cgucacccuc      660

gaccccaacu uccuggacgc cuacaucaac cugggcaacg ugcucaagga ggcgcgcauc      720

uucgaccggg ccguggccgc cuaccugcgc gcgcugagcc ucucccccaa ccacgccguc      780

gugcacggca accuggccug cguguacuac gagcaggggc ugaucgaccu cgccaucgac      840

acguaccggc gcgccaucga gcugcagccc cacuucccgg acgcguacug caaccuggcc      900

aacgcccuca aggagaaggg cagcgucgcc gaggccgagg acugcuacaa caccgcgcug      960

cggcugugcc ccacccacgc cgacucccuc aacaaccugg ccaacaucaa gcgcgagcag     1020

gggaacaucg aggaggccgu gcggcuguac cgcaaggccc ucgagguguu ccccgaguuc     1080

gcggccgccc acagcaaccu ggccuccguc cugcagcagc agggcaagcu ccaggaggcg     1140

cugaugcacu acaaggaggc cauccggauc agccccaccu ucgccgacgc cuacuccaac     1200

augggcaaca cgcugaagga gaugcaggac gugcaggggg cccugcagug cuacacccgc     1260

gcgauccaga ucaacccggc cuucgccgac gcccacagca accucgccag cauccacaag     1320

gacuccggca acauccccga ggcgaucgcc agcuaccgca ccgcccugaa gcugaagccc     1380

gacuuccccg acgccuacug caaccucgcc cacugccugc agaucgugug cgacuggacc     1440

gacuacgacg agcggaugaa gaagcugguc uccaucgugg cggaccagcu cgagaagaac     1500

cgccugccga gcgugcaccc ccaccacucc augcuguacc cccucagcca cggguuccgg     1560

aaggccaucg ccgagcgcca cggcaaccug ugccuggaca agaucaacgu ccuccacaag     1620

cccccguacg agcaccccaa ggaccugaag cuguccgacg ggcggcuccg cgugggcuac     1680

gucagcuccg acuucggcaa ccaccccacg agccaccuga ugcaguccau ccccgggaug     1740

cacaacccgg acaaguucga gguguucugc uacgcccuga gccccgacga cggcaccaac     1800

uuccggguga aggucauggc ggaggccaac cacuucaucg accucuccca gauccccugc     1860

aacgggaagg ccgccgaccg cauccaccag gacggcaucc acauccuggu gaacaugaac     1920

ggguacacca agggcgcccg gaacgagcug uucgcgcucc gccccgcccc gauccaggcc     1980

auguggcugg gcuaccccgg gaccagcggc gcccuguuca uggacuacau caucacggac     2040

caggagaccu cccccgccga gguggcggag caguacagcg agaagcucgc cuacaugccg     2100

cacaccuucu ucaucgggga ccacgccaac auguuccccc accugaagaa gaaggccguc     2160

aucgacuuca aguccaacgg ccacaucuac gacaaccgga ucgugcugaa cgggaucgac     2220

cucaaggccu uccuggacag ccugcccgac gugaagaucg ucaagaugaa gugccccgac     2280

ggcggcgaca acgcggacuc cagcaacacc gcccucaaca ugccggugau ccccaugaac     2340

acgaucgccg aggccgugau cgagaugauc aaccgcgggc agauccagau caccaucaac     2400

ggcuucagca ucuccaacgg gcuggccacc acccagauca acaacaaggc ggccacgggc     2460

gaggaggucc cccggaccau caucgugacc acccgcagcc aguacggccu gcccgaggac     2520

gccaucgugu acugcaacuu caaccagcuc uacaagaucg acccguccac gcugcagaug     2580

ugggccaaca uccugaagcg gguccccaac agcgugcucu ggcugcugcg cuuccccgcg     2640

gugggggagc ccaacaucca gcaguacgcc cagaacaugg gccucccgca gaaccggauc     2700

aucuucuccc ccgucgcccc caaggaggag cacgugcgcc gggggcagcu ggccgacgug     2760

ugccuggaca cgccccucug caacggccac accaccggga uggacguccu gugggccggc     2820

accccgaugg ugaccaugcc cggcgagacc cuggcgagcc gcguggccgc cucccagcug     2880

accugccucg ggugccugga gcucaucgcc aagaaccgcc aggaguacga ggacaucgcc     2940

gucaagcugg gcacggaccu ggaguaccuc aagaaggugc gggggaaggu guggaagcag     3000

cgcaucagca gcccccuguu caacaccaag caguacacca uggagcugga gcggcucuac     3060

cugcagaugu gggagcacua cgcggccggc aacaagcccg accacaugau caagccgguc     3120

gaggugaccg aguccgccug a                                               3141


<210>  2928
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OGT__Homo_sapiens__AAH38180

<400>  2928
auggccuccu ccgucggcaa cgucgccgac uccaccgagc ccaccaagcg caugcucucc       60

uuccagggcc ucgccgagcu cgcccaccgc gaguaccagg ccggcgacuu cgaggccgcc      120

gagcgccacu gcaugcagcu cuggcgccag gagcccgaca acaccggcgu ccuccuccuc      180

cucuccucca uccacuucca gugccgccgc cucgaccgcu ccgcccacuu cuccacccuc      240

gccaucaagc agaacccccu ccucgccgag gccuacucca accucggcaa cgucuacaag      300

gagcgcggcc agcuccagga ggccaucgag cacuaccgcc acgcccuccg ccucaagccc      360

gacuucaucg acggcuacau caaccucgcc gccgcccucg ucgccgccgg cgacauggag      420

ggcgccgucc aggccuacgu cuccgcccuc caguacaacc ccgaccucua cugcguccgc      480

uccgaccucg gcaaccuccu caaggcccuc ggccgccucg aggaggccaa ggccugcuac      540

cucaaggcca ucgagaccca gcccaacuuc gccgucgccu gguccaaccu cggcugcguc      600

uucaacgccc agggcgagau cuggcucgcc auccaccacu ucgagaaggc cgucacccuc      660

gaccccaacu uccucgacgc cuacaucaac cucggcaacg uccucaagga ggcccgcauc      720

uucgaccgcg ccgucgccgc cuaccuccgc gcccucuccc ucucccccaa ccacgccguc      780

guccacggca accucgccug cgucuacuac gagcagggcc ucaucgaccu cgccaucgac      840

accuaccgcc gcgccaucga gcuccagccc cacuuccccg acgccuacug caaccucgcc      900

aacgcccuca aggagaaggg cuccgucgcc gaggccgagg acugcuacaa caccgcccuc      960

cgccucugcc ccacccacgc cgacucccuc aacaaccucg ccaacaucaa gcgcgagcag     1020

ggcaacaucg aggaggccgu ccgccucuac cgcaaggccc ucgaggucuu ccccgaguuc     1080

gccgccgccc acuccaaccu cgccuccguc cuccagcagc agggcaagcu ccaggaggcc     1140

cucaugcacu acaaggaggc cauccgcauc ucccccaccu ucgccgacgc cuacuccaac     1200

augggcaaca cccucaagga gaugcaggac guccagggcg cccuccagug cuacacccgc     1260

gccauccaga ucaaccccgc cuucgccgac gcccacucca accucgccuc cauccacaag     1320

gacuccggca acauccccga ggccaucgcc uccuaccgca ccgcccucaa gcucaagccc     1380

gacuuccccg acgccuacug caaccucgcc cacugccucc agaucgucug cgacuggacc     1440

gacuacgacg agcgcaugaa gaagcucguc uccaucgucg ccgaccagcu cgagaagaac     1500

cgccuccccu ccguccaccc ccaccacucc augcucuacc cccucuccca cggcuuccgc     1560

aaggccaucg ccgagcgcca cggcaaccuc ugccucgaca agaucaacgu ccuccacaag     1620

ccccccuacg agcaccccaa ggaccucaag cucuccgacg gccgccuccg cgucggcuac     1680

gucuccuccg acuucggcaa ccaccccacc ucccaccuca ugcaguccau ccccggcaug     1740

cacaaccccg acaaguucga ggucuucugc uacgcccucu cccccgacga cggcaccaac     1800

uuccgcguca aggucauggc cgaggccaac cacuucaucg accucuccca gauccccugc     1860

aacggcaagg ccgccgaccg cauccaccag gacggcaucc acauccucgu caacaugaac     1920

ggcuacacca agggcgcccg caacgagcuc uucgcccucc gccccgcccc cauccaggcc     1980

auguggcucg gcuaccccgg caccuccggc gcccucuuca uggacuacau caucaccgac     2040

caggagaccu cccccgccga ggucgccgag caguacuccg agaagcucgc cuacaugccc     2100

cacaccuucu ucaucggcga ccacgccaac auguuccccc accucaagaa gaaggccguc     2160

aucgacuuca aguccaacgg ccacaucuac gacaaccgca ucguccucaa cggcaucgac     2220

cucaaggccu uccucgacuc ccuccccgac gucaagaucg ucaagaugaa gugccccgac     2280

ggcggcgaca acgccgacuc cuccaacacc gcccucaaca ugcccgucau ccccaugaac     2340

accaucgccg aggccgucau cgagaugauc aaccgcggcc agauccagau caccaucaac     2400

ggcuucucca ucuccaacgg ccucgccacc acccagauca acaacaaggc cgccaccggc     2460

gaggaggucc cccgcaccau caucgucacc acccgcuccc aguacggccu ccccgaggac     2520

gccaucgucu acugcaacuu caaccagcuc uacaagaucg accccuccac ccuccagaug     2580

ugggccaaca uccucaagcg cguccccaac uccguccucu ggcuccuccg cuuccccgcc     2640

gucggcgagc ccaacaucca gcaguacgcc cagaacaugg gccuccccca gaaccgcauc     2700

aucuucuccc ccgucgcccc caaggaggag cacguccgcc gcggccagcu cgccgacguc     2760

ugccucgaca ccccccucug caacggccac accaccggca uggacguccu cugggccggc     2820

acccccaugg ucaccaugcc cggcgagacc cucgccuccc gcgucgccgc cucccagcuc     2880

accugccucg gcugccucga gcucaucgcc aagaaccgcc aggaguacga ggacaucgcc     2940

gucaagcucg gcaccgaccu cgaguaccuc aagaaggucc gcggcaaggu cuggaagcag     3000

cgcaucuccu ccccccucuu caacaccaag caguacacca uggagcucga gcgccucuac     3060

cuccagaugu gggagcacua cgccgccggc aacaagcccg accacaugau caagcccguc     3120

gaggucaccg aguccgccug a                                               3141


<210>  2929
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OGT__Homo_sapiens__AAH38180

<400>  2929
auggccagcu ccgugggcaa cgucgcugac ucuaccgagc ccacaaagag aaugcuguca       60

uuccaggggc ucgcagaacu ugcccacagg gaguaccaag cgggagauuu ugaagcugcc      120

gagcggcauu gcaugcagcu guggcgccag gaaccugaca auacuggugu uuuguuacug      180

cuaaguagca uccacuucca gugucgacgu cucgauagau ccgcacauuu uucuacgcug      240

gccauuaaac aaaacccacu ucuggcugag gcauauucga auuugggcaa cguguacaag      300

gagagggggc agcuccagga agccauagag cacuaucggc augcucugcg ccugaaaccg      360

gacuucaucg auggauacau uaaucucgcc gcggcauuag uagccgcugg cgacauggaa      420

ggugccgugc aggcauaugu cucagcucug caauacaacc ccgaucuuua uugcgugaga      480

agcgacuugg ggaaucugcu aaaggcccuc ggaaggcugg aggaggcgaa agccuguuac      540

cuuaaggcaa ucgaaaccca gccuaacuuu gcuguugccu ggaguaaucu gggcugcgug      600

uucaacgcuc agggcgagau uugguuggcc auccaccacu uugaaaaggc agucacacuc      660

gauccaaauu uccuggacgc cuacauaaac uuagggaaug ugcugaaaga ggcucggauc      720

uuugaucgcg cgguagcagc cuaucuccga gcucuuuccc ugucucccaa ccaugccguu      780

gugcacggaa auuuggcaug ugucuacuau gaacaggguc uaauugaccu ggccaucgau      840

acuuacagaa gggcuauuga gcuccaaccu cauuucccag acgccuauug caaccuggca      900

aacgcgcuua aggagaaagg cagcguggcu gaagccgagg acuguuacaa uaccgcacug      960

cgguugugcc ccacacacgc cgauucccuc aacaaucugg cuaacaucaa gcgugaacag     1020

gggaauauag aggaagccgu gcgcuuauau agaaaagcac uggaggucuu uccugaguuc     1080

gcugccgcgc acucaaaccu agccaguguu cuccagcaac agggaaagcu gcaggaagcu     1140

cuuaugcauu acaaggaggc aauuaggauc agcccaaccu uugccgacgc uuacucuaau     1200

augggcaaca cuuugaaaga aaugcaggau gugcaaggug cccugcagug uuauacacgg     1260

gcaauucaga ucaauccggc guucgccgac gcucacucca accucgccuc aauccauaag     1320

gauagcggga auauucccga ggcaauagcu aguuaccgaa ccgcccugaa acuuaagccu     1380

gacuucccag augcauauug caaccuggcc cacuguuugc agaucguaug cgacuggacg     1440

gauuacgacg aacgcaugaa aaagcucgug ucuauugucg cugaucaacu ggagaaaaau     1500

agauuacccu ccgugcaucc ucaccacagc augcuguauc cacuaucgca uggauuuagg     1560

aaggcgaucg ccgagcggca cggcaaccuc ugccuggaca agauaaaugu ucuucauaaa     1620

cccccguacg aacacccuaa ggacuugaaa cugucugaug gccgccucag agugggguau     1680

gucuccucag acuucggaaa ccaccccacc agucaucuga ugcagagcau uccagguaug     1740

cacaacccug auaaguuuga gguguucugu uacgcauuau cccccgacga uggcacuaau     1800

uuuaggguaa aaguuauggc ugaagccaac cauuucaucg accugucuca gaucccaugc     1860

aaugggaagg ccgcugaucg uauucaccag gacggaaucc auauucuugu gaacaugaau     1920

ggcuacacaa agggugcacg gaacgaguug uuugcccucc gacccgcgcc uauacaagcu     1980

auguggcugg gguauccagg cacuagcgga gcccuauuca uggauuacau cauuaccgac     2040

caggagacau caccggcaga agucgccgag caguauagug aaaaacuggc uuacaugccc     2100

cacaccuuuu ucaucggcga ucacgcaaau auguuuccuc aucucaagaa aaaggccgug     2160

aucgacuuca aauccaacgg gcacauuuau gauaauagaa uaguccugaa cggaaucgac     2220

cuuaaggcgu uuuuggacag ccugccagau gugaagauug uuaaaaugaa gugucccgac     2280

gguggcgaua augcugacuc uucaaacacg gccuuaaaua ugccugugau cccaaugaac     2340

acuauugcag aggccguaau cgaaaugaua aauagggggc agauccaaau uacaaucaac     2400

ggauucagua uuagcaacgg ccucgcuacc acucagauca auaacaaagc cgcaacaggu     2460

gaggaggucc cccgcaccau aauugugacg acccgguccc aguacgggcu gccggaagau     2520

gcuaucguuu auugcaauuu caaccaacuu uacaagauug acccuucuac acugcagaug     2580

ugggccaaua ucuugaaaag agugccaaac ucgguccucu ggcugcuaag guuucccgcg     2640

gugggcgagc cuaauauaca gcaguacgcc caaaacaugg gacugcccca gaaucgcauc     2700

auuuucagcc caguagcacc uaaggaggaa caugugcgac ggggccagcu cgcugauguu     2760

ugucuggaca cuccccuuug caacgggcac accacaggaa uggaugucuu gugggccggu     2820

acuccaaugg ugaccaugcc gggcgaaaca cuggcuuccc guguggcagc cucacaguua     2880

accugucucg ggugccugga gcuuaucgcc aagaauagac aagaguauga agacauugcu     2940

gucaaacugg gaacugaucu agaguaccuc aagaaaguua ggggcaaggu guggaaacag     3000

cgcaucaguu cuccucuguu uaacacgaag caguauacaa uggaauugga gcggcuguac     3060

uuacagaugu gggaacauua ugcggcaggu aauaaacccg accacaugau aaagccagug     3120

gagguaaccg agagcgccug a                                               3141


<210>  2930
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OGT__Homo_sapiens__AAH38180

<400>  2930
auggccagca gcgugggcaa cguggccgac agcaccgagc ccaccaagag aaugcugagc       60

uuccagggcc uggccgagcu ggcccacaga gaguaccagg ccggcgacuu cgaggccgcc      120

gagagacacu gcaugcagcu guggagacag gagcccgaca acaccggcgu gcugcugcug      180

cugagcagca uccacuucca gugcagaaga cuggacagaa gcgcccacuu cagcacccug      240

gccaucaagc agaacccccu gcuggccgag gccuacagca accugggcaa cguguacaag      300

gagagaggcc agcugcagga ggccaucgag cacuacagac acgcccugag acugaagccc      360

gacuucaucg acggcuacau caaccuggcc gccgcccugg uggccgccgg cgacauggag      420

ggcgccgugc aggccuacgu gagcgcccug caguacaacc ccgaccugua cugcgugaga      480

agcgaccugg gcaaccugcu gaaggcccug ggcagacugg aggaggccaa ggccugcuac      540

cugaaggcca ucgagaccca gcccaacuuc gccguggccu ggagcaaccu gggcugcgug      600

uucaacgccc agggcgagau cuggcuggcc auccaccacu ucgagaaggc cgugacccug      660

gaccccaacu uccuggacgc cuacaucaac cugggcaacg ugcugaagga ggccagaauc      720

uucgacagag ccguggccgc cuaccugaga gcccugagcc ugagccccaa ccacgccgug      780

gugcacggca accuggccug cguguacuac gagcagggcc ugaucgaccu ggccaucgac      840

accuacagaa gagccaucga gcugcagccc cacuuccccg acgccuacug caaccuggcc      900

aacgcccuga aggagaaggg cagcguggcc gaggccgagg acugcuacaa caccgcccug      960

agacugugcc ccacccacgc cgacagccug aacaaccugg ccaacaucaa gagagagcag     1020

ggcaacaucg aggaggccgu gagacuguac agaaaggccc uggagguguu ccccgaguuc     1080

gccgccgccc acagcaaccu ggccagcgug cugcagcagc agggcaagcu gcaggaggcc     1140

cugaugcacu acaaggaggc caucagaauc agccccaccu ucgccgacgc cuacagcaac     1200

augggcaaca cccugaagga gaugcaggac gugcagggcg cccugcagug cuacaccaga     1260

gccauccaga ucaaccccgc cuucgccgac gcccacagca accuggccag cauccacaag     1320

gacagcggca acauccccga ggccaucgcc agcuacagaa ccgcccugaa gcugaagccc     1380

gacuuccccg acgccuacug caaccuggcc cacugccugc agaucgugug cgacuggacc     1440

gacuacgacg agagaaugaa gaagcuggug agcaucgugg ccgaccagcu ggagaagaac     1500

agacugccca gcgugcaccc ccaccacagc augcuguacc cccugagcca cggcuucaga     1560

aaggccaucg ccgagagaca cggcaaccug ugccuggaca agaucaacgu gcugcacaag     1620

ccccccuacg agcaccccaa ggaccugaag cugagcgacg gcagacugag agugggcuac     1680

gugagcagcg acuucggcaa ccaccccacc agccaccuga ugcagagcau ccccggcaug     1740

cacaaccccg acaaguucga gguguucugc uacgcccuga gccccgacga cggcaccaac     1800

uucagaguga aggugauggc cgaggccaac cacuucaucg accugagcca gauccccugc     1860

aacggcaagg ccgccgacag aauccaccag gacggcaucc acauccuggu gaacaugaac     1920

ggcuacacca agggcgccag aaacgagcug uucgcccuga gacccgcccc cauccaggcc     1980

auguggcugg gcuaccccgg caccagcggc gcccuguuca uggacuacau caucaccgac     2040

caggagacca gccccgccga gguggccgag caguacagcg agaagcuggc cuacaugccc     2100

cacaccuucu ucaucggcga ccacgccaac auguuccccc accugaagaa gaaggccgug     2160

aucgacuuca agagcaacgg ccacaucuac gacaacagaa ucgugcugaa cggcaucgac     2220

cugaaggccu uccuggacag ccugcccgac gugaagaucg ugaagaugaa gugccccgac     2280

ggcggcgaca acgccgacag cagcaacacc gcccugaaca ugcccgugau ccccaugaac     2340

accaucgccg aggccgugau cgagaugauc aacagaggcc agauccagau caccaucaac     2400

ggcuucagca ucagcaacgg ccuggccacc acccagauca acaacaaggc cgccaccggc     2460

gaggaggugc ccagaaccau caucgugacc accagaagcc aguacggccu gcccgaggac     2520

gccaucgugu acugcaacuu caaccagcug uacaagaucg accccagcac ccugcagaug     2580

ugggccaaca uccugaagag agugcccaac agcgugcugu ggcugcugag auuccccgcc     2640

gugggcgagc ccaacaucca gcaguacgcc cagaacaugg gccugcccca gaacagaauc     2700

aucuucagcc ccguggcccc caaggaggag cacgugagaa gaggccagcu ggccgacgug     2760

ugccuggaca ccccccugug caacggccac accaccggca uggacgugcu gugggccggc     2820

acccccaugg ugaccaugcc cggcgagacc cuggccagca gaguggccgc cagccagcug     2880

accugccugg gcugccugga gcugaucgcc aagaacagac aggaguacga ggacaucgcc     2940

gugaagcugg gcaccgaccu ggaguaccug aagaagguga gaggcaaggu guggaagcag     3000

agaaucagca gcccccuguu caacaccaag caguacacca uggagcugga gagacuguac     3060

cugcagaugu gggagcacua cgccgccggc aacaagcccg accacaugau caagcccgug     3120

gaggugaccg agagcgccug a                                               3141


<210>  2931
<211>  3141
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OGT__Homo_sapiens__AAH38180

<400>  2931
auggccagcu ccgugggcaa cgucgcugac ucuaccgagc ccacaaagag aaugcugagc       60

uuccaggggc ucgccgaacu ggcgcaccgg gaguaccaag cuggagauuu ugaagccgcc      120

gagcgccauu gcaugcagcu uuggagacag gaaccugaca auacgggcgu ucugcuccug      180

cuuuccucua uccacuucca gugucggcgc cuggauagaa gcgcucauuu uuccacccuc      240

gccauuaaac aaaacccgcu gcuggcugag gccuauucua aucucgggaa cguguacaag      300

gagcggggac agcugcagga agcgaucgag cacuaucgcc augcccuuag acugaaaccc      360

gacuucauug auggcuacau caaucucgcu gccgcucugg uggccgcggg ggacauggaa      420

ggagccgucc aggcuuaugu gagcgcccuu caauacaacc cugaucugua uugcguucgg      480

uccgaccucg gcaaucugcu gaaggcucuc ggccgccugg aggaggccaa agccuguuac      540

cuuaaggcua uugaaacaca gcccaacuuu gcgguggccu ggagcaaucu ggggugcguc      600

uucaacgcuc agggagagau cuggcucgcc auccaccacu uugaaaaggc cgugacccug      660

gauccuaauu uccuugacgc uuacauuaac cugggcaaug uucucaaaga ggccagaauc      720

uuugaucggg cgguggcugc cuaucugcgc gcccugucuc ucucccccaa ccaugcuguc      780

gugcacggga aucuggccug uguguacuau gaacagggac uuauugaccu ggcuaucgau      840

acauacagac gggccauuga gcuccaaccu cauuucccgg acgcguauug caaccuggcc      900

aacgcucuua aggagaaagg cagcgucgcc gaagcugagg acuguuacaa uaccgcccug      960

cgccucugcc ccacacacgc ggauucucug aacaaucugg ccaacaucaa gagagaacag     1020

gggaauauug aggaagcugu ucggcucuau agaaaagccc uggagguguu uccugaguuc     1080

gcugccgccc acuccaaccu ugcuagcgug cugcagcaac agggaaagcu ccaggaagcg     1140

cugaugcauu acaaggaggc cauccgcauc ucucccaccu uugcugacgc cuacuccaau     1200

augggcaaca cgcugaaaga aaugcaggau guccaaggcg cccuucagug uuauacccgg     1260

gcuauucaga ucaauccugc cuucgcggac gcucacagca accucgccuc cauucauaag     1320

gauucuggga auauccccga ggccauugcu agcuacagaa cagcccugaa acugaagccg     1380

gacuucccug augcguauug caaccucgcu cacugucugc agaucgugug cgacuggacc     1440

gauuacgacg aacgcaugaa aaagcugguu uccaucgugg ccgaucaacu ugagaaaaau     1500

cggcucccca gcguccaucc ucaccacucu augcuguauc cccuguccca uggauuuaga     1560

aaggccauug cugagcgcca cggcaaccuu ugccucgaca agaucaaugu gcugcauaaa     1620

cccccuuacg aacacccgaa ggaccugaaa cucagcgaug ggcggcugag aguuggauau     1680

gugucuagcg acuucggcaa ccaccccaca ucccaucuua ugcagucuau uccugggaug     1740

cacaaccccg auaaguuuga ggucuucugu uacgcccuga gcccugacga uggaaccaau     1800

uuucgcguga aagucauggc ugaagccaac cauuucaucg accucuccca gauucccugc     1860

aauggcaagg cggccgaucg gauccaccag gacggcaucc auauucuggu gaacaugaau     1920

ggguacacga agggagcuag aaacgagcug uuugcccuuc gcccggcucc uauccaagcc     1980

auguggcucg gcuaucccgg gacaagcgga gcccuguuca uggauuacau uaucaccgac     2040

caggagacau cuccugcuga aguugcggag caguauuccg aaaaacuggc cuacaugccc     2100

cacaccuuuu ucauuggcga ucacgcuaau auguuuccuc aucucaagaa aaaggccgug     2160

aucgacuuca aaagcaacgg gcacauuuau gauaaucgga ucguccugaa cggcaucgac     2220

cuuaaggccu uucuggacuc ucuccccgau gugaagauug uuaaaaugaa guguccggac     2280

ggaggcgaua augcugacuc cagcaacacc gcccugaaua ugccugugau ccccaugaac     2340

acaauugcgg aggcugucau cgaaaugauu aauagagggc agauccaaau cacgauuaac     2400

ggauucucca ucucuaacgg ccuggccacc acacagauua auaacaaagc cgcuaccggg     2460

gaggaggugc cccggacaau cauugugacc acgcgcagcc aguacggacu uccugaagau     2520

gccaucguuu auugcaauuu caaccaacuc uacaagaucg acccguccac acugcagaug     2580

ugggcgaaua uucugaaaag aguccccaac ucugugcucu ggcugcuucg guuuccugcu     2640

gugggcgagc ccaauaucca gcaguacgcc caaaacaugg ggcugccuca gaauagaauu     2700

aucuucagcc ccgucgcccc uaaggaggaa caugugcgcc ggggccagcu cgcugauguu     2760

ugucuggaca caccccugug caacggacac accaccggca uggaugugcu uugggccggg     2820

accccgaugg ucacaaugcc uggagaaacg cuggcuucca gaguggccgc gagccagcuc     2880

accugucugg gcugccucga gcugauugcc aagaaucgcc aagaguauga agacaucgcu     2940

guuaaacuug ggacagaucu ggaguaccuc aagaaaguga gaggaaaggu cuggaaacag     3000

cggaucucua gcccccuguu uaacaccaag caguauacaa uggaacugga gcgccuuuac     3060

cugcagaugu gggaacauua ugccgcuggc aauaaaccug accacaugau uaagcccgug     3120

gagguuaccg aguccgccug a                                               3141


<210>  2932
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__B4DH11

<400>  2932

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Val Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Leu Gln Ala Ala 
    130                 135                 140                 


Ser Ser 
145     


<210>  2933
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__BAG57972

<400>  2933
auggcggcgg aaacgcugcu guccaguuug uuaggacugc ugcuucuggg acuccuguua       60

cccgcaaguc ugaccggcgg ugucgggagu cugaaccugg aggagcugag ugagaugcgu      120

uaugggaucg agauccugcc guugccuguc augggagggc agagccaauc uucggacgug      180

gugauugucu ccucuaagua caaacagcgc uaugaguguc gccugccagu uggagcuauu      240

cacuuccagc gugaaaggga ggaggaaaca ccugcuuacc aagggccugg gaucccugag      300

uuguugagcc caaugagaga ugcucccugc uugcugaaga caaaggacug guggacauau      360

gaauucuguu auggacgcca cauccagcaa uaccacaugg aagauucaga gaucaaaggc      420

cuccaagcag caucgucuua a                                                441


<210>  2934
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OS-9__Homo_sapiens__BAG57972

<400>  2934
auggccgccg agacccugcu cagcucccug cugggccucc ugcugcucgg gcugcugcuc       60

cccgcgagcc ugaccggcgg ggugggcucc cugaaccucg aggagcugag cgagaugcgc      120

uacgggaucg agauccugcc gcuccccguc augggcggcc agucccagag cuccgacgug      180

gugaucguca gcuccaagua caagcagcgg uacgagugcc gccugcccgu gggggccauc      240

cacuuccagc gggagcgcga ggaggagacg cccgccuacc agggcccggg gauccccgag      300

cugcucagcc ccaugcggga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggg      420

cuccaggccg cgagcuccug a                                                441


<210>  2935
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OS-9__Homo_sapiens__BAG57972

<400>  2935
auggccgccg agacccuccu cuccucccuc cucggccucc uccuccucgg ccuccuccuc       60

cccgccuccc ucaccggcgg cgucggcucc cucaaccucg aggagcucuc cgagaugcgc      120

uacggcaucg agauccuccc ccuccccguc augggcggcc agucccaguc cuccgacguc      180

gucaucgucu ccuccaagua caagcagcgc uacgagugcc gccuccccgu cggcgccauc      240

cacuuccagc gcgagcgcga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cuccucuccc ccaugcgcga cgcccccugc cuccucaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggc      420

cuccaggccg ccuccuccug a                                                441


<210>  2936
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OS-9__Homo_sapiens__BAG57972

<400>  2936
auggccgcug agacccugcu cagcucccuu cugggcuugu uacugcuagg gcuccugcuu       60

cccgcaucuc ugacaggagg ugugggcuca uugaaccucg aggaacugag ugaaaugaga      120

uacgggaucg agauucugcc ucucccaguc augggaggcc agagccaauc cucugacguu      180

gugauaguau cgucaaagua uaaacagagg uacgaaugcc gguuaccggu gggugccauc      240

cacuuccagc gcgagcgaga ggaagagacu cccgcguauc aggggccugg cauuccagaa      300

cugcuuagcc ccaugcguga ugcuccuugu uugcugaaga cgaaagacug guggaccuac      360

gaguuuugcu auggaagaca uauccaacag uaccacaugg aggauaguga aauuaagggc      420

cuacaggccg cauccucuug a                                                441


<210>  2937
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OS-9__Homo_sapiens__BAG57972

<400>  2937
auggccgccg agacccugcu gagcagccug cugggccugc ugcugcuggg ccugcugcug       60

cccgccagcc ugaccggcgg cgugggcagc cugaaccugg aggagcugag cgagaugaga      120

uacggcaucg agauccugcc ccugcccgug augggcggcc agagccagag cagcgacgug      180

gugaucguga gcagcaagua caagcagaga uacgagugca gacugcccgu gggcgccauc      240

cacuuccaga gagagagaga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cugcugagcc ccaugagaga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggcagaca cauccagcag uaccacaugg aggacagcga gaucaagggc      420

cugcaggccg ccagcagcug a                                                441


<210>  2938
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OS-9__Homo_sapiens__BAG57972

<400>  2938
auggccgcug agacccugcu cagcucccug cuuggccugc uccugcuugg gcugcuccug       60

cccgccucuc ugacaggagg cguggggagc cucaaccugg aggaacuuuc cgaaaugaga      120

uacggaaucg agauucugcc ucucccgguc augggcgggc agucucaaag cuccgacguu      180

gugaucgugu cuagcaagua uaaacagcgg uacgaaugcc gccugcccgu cggagcgauu      240

cacuuccaga gagagcggga ggaagagacg ccugcuuauc agggccccgg caucccugaa      300

cuucuguccc ccaugcgcga ugccccuugu cuccugaaga ccaaagacug guggacauac      360

gaguuuugcu augggagaca uauucaacag uaccacaugg aggauagcga aaucaaggga      420

cugcaggccg cuucuuccug a                                                441


<210>  2939
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__B4E321

<400>  2939

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe 
    130                 135                 140                 


Gln Asn Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile 
145                 150                 155                 160 


Arg Phe Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn 
                165                 170                 175     


Ile Gly Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg 
            180                 185                 190         


Glu Pro Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu 
        195                 200                 205             


Glu Glu Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg 
    210                 215                 220                 


Gln Leu Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro 
225                 230                 235                 240 


Ser Asp Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg 
                245                 250                 255     


Glu Leu Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp 
            260                 265                 270         


Gly Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr 
        275                 280                 285             


Ser Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro 
    290                 295                 300                 


Glu Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro 
305                 310                 315                 320 


Pro Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg 
                325                 330                 335     


Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu 
            340                 345                 350         


Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly 
        355                 360                 365             


Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser 
    370                 375                 380                 


Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp 
385                 390                 395                 400 


Leu Asp Glu Phe Asp Phe 
                405     


<210>  2940
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__BAG65333

<400>  2940
auggcggcgg aaacgcugcu guccaguuug uuaggacugc ugcuucuggg acuccuguua       60

cccgcaaguc ugaccggcgg ugucgggagc cugaaccugg aggagcugag ugagaugcgu      120

uaugggaucg agauccugcc guugccuguc augggagggc agagccaauc uucggacgug      180

gugauugucu ccucuaagua caaacagcgc uaugaguguc gccugccagc uggagcuauu      240

cacuuccagc gugaaaggga ggaggaaaca ccugcuuacc aagggccugg gaucccugag      300

uuguugagcc caaugagaga ugcucccugc uugcugaaga caaaggacug guggacauau      360

gaauucuguu auggacgcca cauccagcaa uaccacaugg aagauucagc uucuggugcu      420

cccaaugauu uucagaacaa cgugcagguc aaagucauuc gaagcccugc ggauuugauu      480

cgauucauag aggagcugaa agguggaaca aaaaagggga agccaaauau aggccaagag      540

cagccugugg augaugcugc agaagucccu cagagggaac cagagaagga aaggggugau      600

ccagaacggc agagagagau ggaagaagag gaggaugagg augaggauga ggaugaagau      660

gaggaugaac ggcaguuacu gggagaauuu gagaaggaac uggaagggau ccugcuuccg      720

ucagaccgag accggcuccg uucggaggug aaggcuggca uggagcggga acuggaaaac      780

aucauccagg agacagagaa agagcuggac ccagaugggc ugaagaagga gucagagcgg      840

gaucgggcaa ugcuggcucu cacauccacu cucaacaaac ucaucaaaag acuggaggaa      900

aaacagaguc cagagcuggu gaagaagcac aagaaaaaga ggguuguccc caaaaagccu      960

cccccaucac cccaaccuac agggaaaauu gagaucaaaa uuguccgccc augggcugaa     1020

gggacugaag agggugcacg uuggcugacu gaugaggaca cgagaaaccu caaggagauc     1080

uucuucaaua ucuuggugcc gggagcugaa gaggcccaga aggaacgcca gcggcagaaa     1140

gagcuggaga gcaauuaccg ccgggugugg ggcucuccag guggggaggg cacaggggac     1200

cuggacgaau uugacuucug a                                               1221


<210>  2941
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OS-9__Homo_sapiens__BAG65333

<400>  2941
auggccgccg agacccugcu cagcucccug cugggccucc ugcugcucgg gcugcugcuc       60

cccgcgagcc ugaccggcgg ggugggcucc cugaaccucg aggagcugag cgagaugcgc      120

uacgggaucg agauccugcc gcuccccguc augggcggcc agucccagag cuccgacgug      180

gugaucguca gcuccaagua caagcagcgg uacgagugcc gccugcccgc cggggccauc      240

cacuuccagc gggagcgcga ggaggagacg cccgccuacc agggcccggg gauccccgag      300

cugcucagcc ccaugcggga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccgc gagcggggcc      420

ccgaacgacu uccagaacaa cguccaggug aaggugaucc ggucccccgc cgaccucauc      480

cgcuucaucg aggagcugaa gggcggcacc aagaagggga agcccaacau cggccaggag      540

cagcccgugg acgacgccgc ggaggugccg cagcgggagc ccgagaagga gcgcggggac      600

cccgagcggc agcgcgagau ggaggaggag gaggacgagg acgaggacga ggacgaggac      660

gaggacgagc ggcagcugcu cggcgaguuc gagaaggagc uggagggcau ccugcucccc      720

agcgaccgcg accggcugcg cuccgagguc aaggccggga uggagcggga gcuggagaac      780

aucauccagg agacggagaa ggagcucgac ccggacggcc ugaagaagga gagcgagcgc      840

gaccgggcca ugcuggcccu caccuccacc cugaacaagc ugaucaagcg ccucgaggag      900

aagcagagcc ccgagcuggu gaagaagcac aagaagaagc gggugguccc caagaagccc      960

ccgcccagcc cccagcccac cgggaagauc gagaucaaga ucgugcgccc gugggccgag     1020

ggcacggagg agggggcgcg cuggcugacc gacgaggaca cccggaaccu caaggagauc     1080

uucuucaaca uccuggugcc cggcgccgag gaggcccaga aggagcgcca gcggcagaag     1140

gagcuggagu ccaacuaccg ccgggucugg ggcagccccg ggggcgaggg gaccggcgac     1200

cucgacgagu ucgacuucug a                                               1221


<210>  2942
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OS-9__Homo_sapiens__BAG65333

<400>  2942
auggccgccg agacccuccu cuccucccuc cucggccucc uccuccucgg ccuccuccuc       60

cccgccuccc ucaccggcgg cgucggcucc cucaaccucg aggagcucuc cgagaugcgc      120

uacggcaucg agauccuccc ccuccccguc augggcggcc agucccaguc cuccgacguc      180

gucaucgucu ccuccaagua caagcagcgc uacgagugcc gccuccccgc cggcgccauc      240

cacuuccagc gcgagcgcga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cuccucuccc ccaugcgcga cgcccccugc cuccucaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccgc cuccggcgcc      420

cccaacgacu uccagaacaa cguccagguc aaggucaucc gcucccccgc cgaccucauc      480

cgcuucaucg aggagcucaa gggcggcacc aagaagggca agcccaacau cggccaggag      540

cagcccgucg acgacgccgc cgaggucccc cagcgcgagc ccgagaagga gcgcggcgac      600

cccgagcgcc agcgcgagau ggaggaggag gaggacgagg acgaggacga ggacgaggac      660

gaggacgagc gccagcuccu cggcgaguuc gagaaggagc ucgagggcau ccuccucccc      720

uccgaccgcg accgccuccg cuccgagguc aaggccggca uggagcgcga gcucgagaac      780

aucauccagg agaccgagaa ggagcucgac cccgacggcc ucaagaagga guccgagcgc      840

gaccgcgcca ugcucgcccu caccuccacc cucaacaagc ucaucaagcg ccucgaggag      900

aagcaguccc ccgagcucgu caagaagcac aagaagaagc gcgucguccc caagaagccc      960

ccccccuccc cccagcccac cggcaagauc gagaucaaga ucguccgccc cugggccgag     1020

ggcaccgagg agggcgcccg cuggcucacc gacgaggaca cccgcaaccu caaggagauc     1080

uucuucaaca uccucguccc cggcgccgag gaggcccaga aggagcgcca gcgccagaag     1140

gagcucgagu ccaacuaccg ccgcgucugg ggcucccccg gcggcgaggg caccggcgac     1200

cucgacgagu ucgacuucug a                                               1221


<210>  2943
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OS-9__Homo_sapiens__BAG65333

<400>  2943
auggccgcug agacccugcu cagcucccuu cugggcuugu uacugcuagg gcuccugcuu       60

cccgcaucuc ugacaggagg ugugggcuca uugaaccucg aagaacugag ugaaaugaga      120

uacgggaucg agauucugcc ucucccaguc augggaggcc agagccaauc cucugacguu      180

gugauaguau cgucaaagua uaaacagagg uacgaaugcc gguuaccggc cggugcgauc      240

cacuuccagc gcgagcgaga ggaagagacu cccgcuuauc aggggccugg cauuccagaa      300

cugcuuagcc ccaugcguga ugccccuugu uugcugaaga cgaaagacug guggaccuac      360

gaguuuugcu auggaagaca uauccaacag uaccacaugg aggauagugc auccggcgcc      420

ccaaaugacu uccagaacaa ugugcagguc aaggugauua ggucucccgc ugaucuaauc      480

cgguuuauag aggagcucaa agggggaaca aagaagggua aaccuaacau cggccaagaa      540

cagccaguug acgaugcagc cgaggugccg cagcgcgaac ccgagaagga gagaggggac      600

ccugaaaggc agcgggagau ggaagaggaa gaggaugagg acgaagauga ggacgaagau      660

gaggacgaac gccaacugcu uggagaguuc gagaaagaac uggagggcau uuugcuccca      720

agcgaccgag auagacugag guccgaaguc aaggcuggua uggagcggga guuagaaaau      780

aucauucagg agacugaaaa agagcuggac cccgaugggc ucaagaagga aucagagcgu      840

gaccgcgcca ugcuugcgcu gaccaguaca uugaacaaac uaaucaagag acuggaggaa      900

aaacagagcc cugagcucgu gaagaaacau aagaaaaaga ggguaguucc aaagaaaccc      960

ccgccuucuc cccaaccaac cggaaagaua gaaauuaaaa ucgugcggcc uugggcagag     1020

ggcacugaag agggcgcccg auggcugaca gaugaggaca cccgcaaucu uaaggaaauc     1080

uuuuucaaca uucugguccc cggggcugag gaagcccaga aagagagaca gaggcagaag     1140

gaauuggagu ccaauuaucg gcgcgugugg ggaucaccag guggcgaggg gacgggagau     1200

cucgacgaau uugauuucug a                                               1221


<210>  2944
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OS-9__Homo_sapiens__BAG65333

<400>  2944
auggccgccg agacccugcu gagcagccug cugggccugc ugcugcuggg ccugcugcug       60

cccgccagcc ugaccggcgg cgugggcagc cugaaccugg aggagcugag cgagaugaga      120

uacggcaucg agauccugcc ccugcccgug augggcggcc agagccagag cagcgacgug      180

gugaucguga gcagcaagua caagcagaga uacgagugca gacugcccgc cggcgccauc      240

cacuuccaga gagagagaga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cugcugagcc ccaugagaga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggcagaca cauccagcag uaccacaugg aggacagcgc cagcggcgcc      420

cccaacgacu uccagaacaa cgugcaggug aaggugauca gaagccccgc cgaccugauc      480

agauucaucg aggagcugaa gggcggcacc aagaagggca agcccaacau cggccaggag      540

cagcccgugg acgacgccgc cgaggugccc cagagagagc ccgagaagga gagaggcgac      600

cccgagagac agagagagau ggaggaggag gaggacgagg acgaggacga ggacgaggac      660

gaggacgaga gacagcugcu gggcgaguuc gagaaggagc uggagggcau ccugcugccc      720

agcgacagag acagacugag aagcgaggug aaggccggca uggagagaga gcuggagaac      780

aucauccagg agaccgagaa ggagcuggac cccgacggcc ugaagaagga gagcgagaga      840

gacagagcca ugcuggcccu gaccagcacc cugaacaagc ugaucaagag acuggaggag      900

aagcagagcc ccgagcuggu gaagaagcac aagaagaaga gaguggugcc caagaagccc      960

ccccccagcc cccagcccac cggcaagauc gagaucaaga ucgugagacc cugggccgag     1020

ggcaccgagg agggcgccag auggcugacc gacgaggaca ccagaaaccu gaaggagauc     1080

uucuucaaca uccuggugcc cggcgccgag gaggcccaga aggagagaca gagacagaag     1140

gagcuggaga gcaacuacag aagagugugg ggcagccccg gcggcgaggg caccggcgac     1200

cuggacgagu ucgacuucug a                                               1221


<210>  2945
<211>  1221
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OS-9__Homo_sapiens__BAG65333

<400>  2945
auggccgcug agacccugcu cagcucccug cuuggccugc uccugcuugg gcugcuccug       60

cccgccucuc ugacaggagg cguggggagc cucaaccugg aagaacuuuc cgaaaugaga      120

uacggaaucg agauucugcc ucucccgguc augggcgggc agucucaaag cuccgacguu      180

gugaucgugu cuagcaagua uaaacagcgg uacgaaugcc gccugcccgc gggagcuauu      240

cacuuccaga gagagcggga ggaagagacg ccugccuauc agggccccgg caucccugaa      300

cuucuguccc ccaugcgcga ugccccuugu cuccugaaga ccaaagacug guggacauac      360

gaguuuugcu augggagaca uauucaacag uaccacaugg aggauagcgc uucuggagcc      420

ccgaaugacu uccagaacaa uguccaggug aagguuaucc ggucccccgc ugaucugauc      480

cgcuuuauug aggagcucaa aggcgggacc aagaagggaa aaccuaacau cggccaagaa      540

cagcccgugg acgaugccgc ggaggucccu cagagagaac ccgagaagga gcgcggggac      600

ccggaacggc agagagagau ggaagaggaa gaggaugagg acgaagauga ggacgaagau      660

gaggacgaac ggcaacugcu uggagaguuc gagaaagaac uggagggcau ucuccugccu      720

agcgaccgcg auagacuucg gucugaagug aaggccggca uggagcgcga gcuggaaaau      780

aucauucagg agacagaaaa agagcucgac cccgaugggc ugaagaagga auccgagaga      840

gaccgggcua ugcuggcccu caccagcaca cugaacaaac uuaucaagag acuggaggaa      900

aaacagucuc cugagcucgu uaagaaacau aagaaaaagc gcgugguccc caagaaaccc      960

ccuccgagcc cccaaccuac cggaaagauu gaaaucaaaa ucgugcggcc cugggcugag     1020

ggcacggaag agggggccag auggcugacc gaugaggaca cacgcaaucu uaaggaaauc     1080

uuuuucaaca uucuggugcc uggagcggag gaagcccaga aagagcggca gagacagaag     1140

gaacucgagu ccaauuaucg ccgggucugg ggcucccccg ggggagaggg caccggcgau     1200

cuggacgaau uugauuucug a                                               1221


<210>  2946
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__B7Z8E7

<400>  2946

Met Ala Val Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Arg Thr Leu Phe His Leu 
    290                 295                 300                 


Phe Arg Glu Ile His Phe His Phe Phe Pro Ser Pro Asp Leu Thr Val 
305                 310                 315                 320 


Leu Thr Asp Trp Trp Gly Gly Gly Gly Val Glu Lys Tyr His Gly Pro 
                325                 330                 335     


Ser Ser Leu Gly Asp Arg Gly Gly Glu Gly Thr Pro Ser Tyr Leu Leu 
            340                 345                 350         


Pro Ser Val Ser Pro Leu Leu Ser Asp Gln Ser Leu Pro Val Leu Cys 
        355                 360                 365             


Thr Leu Gly Ala Ser Pro Thr Lys Asp Asp Ser Lys Asp Ser Asp Phe 
    370                 375                 380                 


Trp Lys Met Leu Asn Glu Pro Glu Asp Gln Ala Pro Gly Gly Glu Glu 
385                 390                 395                 400 


Val Pro Ala Glu Glu Gln Asp Pro Ser Pro Glu Ala Ala Asp Ser Ala 
                405                 410                 415     


Ser Gly Ala Pro Asn Asp Phe Gln Asn Asn Val Gln Val Lys Val Ile 
            420                 425                 430         


Arg Ser Pro Ala Asp Leu Ile Arg Phe Ile Glu Glu Leu Lys Gly Gly 
        435                 440                 445             


Thr Lys Lys Gly Lys Pro Asn Ile Gly Gln Glu Gln Pro Val Asp Asp 
    450                 455                 460                 


Ala Ala Glu Val Pro Gln Arg Glu Pro Glu Lys Glu Arg Gly Asp Pro 
465                 470                 475                 480 


Glu Arg Gln Arg Glu Met Glu Glu Glu Glu Asp Glu Asp Glu Asp Glu 
                485                 490                 495     


Asp Glu Asp Glu Asp Glu Arg Gln Leu Leu Gly Glu Phe Glu Lys Glu 
            500                 505                 510         


Leu Glu Gly Ile Leu Leu Pro Ser Asp Arg Asp Arg Leu Arg Ser Glu 
        515                 520                 525             


Val Lys Ala Gly Met Glu Arg Glu Leu Glu Asn Ile Ile Gln Glu Thr 
    530                 535                 540                 


Glu Lys Glu Leu Asp Pro Asp Gly Leu Lys Lys Glu Ser Glu Arg Asp 
545                 550                 555                 560 


Arg Ala Met Leu Ala Leu Thr Ser Thr Leu Asn Lys Leu Ile Lys Arg 
                565                 570                 575     


Leu Glu Glu Lys Gln Ser Pro Glu Leu Val Lys Lys His Lys Lys Lys 
            580                 585                 590         


Arg Val Val Pro Lys Lys Pro Pro Pro Ser Pro Gln Pro Thr Glu Glu 
        595                 600                 605             


Asp Pro Glu His Arg Val Arg Val Arg Val Thr Lys Leu Arg Leu Gly 
    610                 615                 620                 


Gly Pro Asn Gln Asp Leu Thr Val Leu Glu Met Lys Arg Glu Asn Pro 
625                 630                 635                 640 


Gln Leu Lys Gln Ile Glu Gly Leu Val Lys Glu Leu Leu Glu Arg Glu 
                645                 650                 655     


Gly Leu Thr Ala Ala Gly Lys Ile Glu Ile Lys Ile Val Arg Pro Trp 
            660                 665                 670         


Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp Thr 
        675                 680                 685             


Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala Glu 
    690                 695                 700                 


Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn Tyr 
705                 710                 715                 720 


Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu Asp 
                725                 730                 735     


Glu Phe Asp Phe 
            740 


<210>  2947
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__BAH13933

<400>  2947
auggcggugg aaacgcugcu guccaguuug uuaggacugc ugcuucuggg acuccuguua       60

cccgcaaguc ugaccggcgg ugucgggagc cugaaccugg aggagcugag ugagaugcgu      120

uaugggaucg agauccugcc guugccuguc augggagggc agagccaauc uucggacgug      180

gugauugucu ccucuaagua caaacagcgc uaugaguguc gccugccagc uggagcuauu      240

cacuuccagc gugaaaggga ggaggaaaca ccugcuuacc aagggccugg gaucccugag      300

uuguugagcc caaugagaga ugcucccugc uugcugaaga caaaggacug guggacauau      360

gaauucuguu auggacgcca cauccagcaa uaccacaugg aagauucaga gaucaaaggu      420

gaaguccucu aucucggcua cuaccaauca gccuucgacu gggaugauga aacagccaag      480

gccuccaagc agcaucgucu uaaacgcuac cacagccaga ccuauggcaa uggguccaag      540

ugcgaccuua augggaggcc ccgggaggcc gagguucggu uccucuguga cgagggugca      600

gguaucucug gggacuacau cgaucgcgug gacgagcccu uguccugcuc uuaugugcug      660

accauucgca cuccucggcu cugcccccac ccucuccucc ggcccccacc cagugcugca      720

ccgcaggcca uccucuguca cccuucccua cagccugagg aguacauggc cuacguucag      780

aggcaagccg acucaaagca guauggagau aaaaucauag aggagcugca agaucuaggc      840

ccccaagugu ggagugagac caagucuggg guggcacccc aaaagauggc agguaggacc      900

uuguuucacc uguuccguga aauucacuuc cauuucuucc cuuccccuga ucuuacuguc      960

cugacugacu gguggggugg ggggggggug gaaaaguacc augggcccuc cucccuuggu     1020

gauagaggag gggaagggac cccauccuau uugcucccuu cugucucacc ccuccuguca     1080

gaucagucuc ucccuguucu cuguacccua ggugcgagcc cgaccaagga ugacaguaag     1140

gacucagauu ucuggaagau gcuuaaugag ccagaggacc aggccccagg aggggaggag     1200

gugccggcug aggagcagga cccaagcccu gaggcagcag auucagcuuc uggugcuccc     1260

aaugauuuuc agaacaacgu gcaggucaaa gucauucgaa gcccugcgga uuugauucga     1320

uucauagagg agcugaaagg uggaacaaaa aaggggaagc caaauauagg ccaagagcag     1380

ccuguggaug augcugcaga agucccucag agggaaccag agaaggaaag gggugaucca     1440

gaacggcaga gagagaugga agaagaggag gaugaggaug aggaugagga ugaagaugag     1500

gaugaacggc aguuacuggg agaauuugag aaggaacugg aagggauccu gcuuccguca     1560

gaccgagacc ggcuccguuc ggaggugaag gcuggcaugg agcgggaacu ggagaacauc     1620

auccaggaga cagagaaaga gcuggaccca gaugggcuga agaaggaguc agagcgggau     1680

cgggcaaugc uggcucucac auccacucuc aacaaacuca ucaaaagacu ggaggaaaaa     1740

cagaguccag agcuggugaa gaagcacaag aaaaagaggg uuguccccaa aaagccuccc     1800

ccaucacccc aaccuacaga ggaggauccu gagcacagag uccggguccg ggucaccaag     1860

cuccgucucg gaggcccuaa ucaggaucug acuguccucg agaugaaacg ggaaaaccca     1920

cagcugaaac aaaucgaggg gcuggugaag gagcugcugg agagggaggg acucacagcu     1980

gcagggaaaa uugagaucaa aauuguccgc ccaugggcug aagggacuga agagggugca     2040

cguuggcuga cugaugagga cacgagaaac cucaaggaga ucuucuucaa uaucuuggug     2100

ccgggagcug aagaggccca gaaggaacgc cagcggcaga aagagcugga gagcaauuac     2160

cgccgggugu ggggcucucc agguggggag ggcacagggg accuggacga auuugacuuc     2220

uga                                                                   2223


<210>  2948
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OS-9__Homo_sapiens__BAH13933

<400>  2948
auggccgugg agacccugcu cagcucccug cugggccucc ugcugcucgg gcugcugcuc       60

cccgccagcc ugaccggcgg ggucggcucc cugaaccucg aggagcugag cgagaugcgc      120

uacgggaucg agauccugcc gcuccccgug augggcggcc agucccagag cuccgacgug      180

gucaucguga gcuccaagua caagcagcgg uacgagugcc gccugcccgc gggggccauc      240

cacuuccagc gggagcgcga ggaggagacg cccgccuacc agggcccggg gauccccgag      300

cugcucagcc ccaugcggga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggg      420

gaggugcucu accugggcua cuaccagagc gccuucgacu gggacgacga gaccgcgaag      480

gccuccaagc agcaccggcu gaagcgcuac cacagccaga cguacggcaa cggguccaag      540

ugcgaccuca acggccggcc gcgcgaggcc gagguccggu uccugugcga cgagggggcc      600

ggcaucagcg gcgacuacau cgaccgcgug gacgagcccc uguccugcag cuacgugcuc      660

accauccgga cgccccgccu gugcccccac ccgcugcucc ggcccccgcc cuccgcggcc      720

ccgcaggcca uccugugcca ccccagccug cagcccgagg aguacauggc cuacguccag      780

cgccaggccg acagcaagca guacggggac aagaucaucg aggagcucca ggaccugggc      840

ccccaggugu gguccgagac caagagcggg guggcgccgc agaagauggc cggccggacc      900

cuguuccacc ucuuccgcga gauccacuuc cacuucuucc ccucccccga ccugaccguc      960

cugaccgacu gguggggcgg gggcggggug gagaaguacc acggccccag cucccucggg     1020

gaccggggcg gggagggcac cccgagcuac cugcugcccu ccgugagccc ccuccugucc     1080

gaccagagcc ugcccguccu cugcacgcug ggcgccuccc cgaccaagga cgacagcaag     1140

gacuccgacu ucuggaagau gcugaacgag cccgaggacc aggcccccgg gggcgaggag     1200

gugccggccg aggagcagga ccccagcccc gaggcggccg acuccgccag cggggccccc     1260

aacgacuucc agaacaacgu gcaggucaag gugauccgcu ccccggccga ccucauccgg     1320

uucaucgagg agcugaaggg cgggaccaag aagggcaagc ccaacaucgg ccaggagcag     1380

cccguggacg acgcggccga ggucccccag cgcgagccgg agaaggagcg cggggacccc     1440

gagcggcagc gcgagaugga ggaggaggag gacgaggacg aggacgagga cgaggacgag     1500

gacgagcggc agcugcuggg cgaguucgag aaggagcucg aggggauccu gcugcccagc     1560

gaccgcgacc ggcuccgcuc cgaggugaag gccggcaugg agcgggagcu ggagaacauc     1620

auccaggaga ccgagaagga gcuggacccc gacggccuca agaaggagag cgagcgcgac     1680

cgggccaugc uggcccugac gagcacccuc aacaagcuga ucaagcgccu ggaggagaag     1740

caguccccgg agcucgugaa gaagcacaag aagaagcggg ucgugcccaa gaagcccccg     1800

cccagccccc agcccaccga ggaggacccc gagcaccgcg uccgggugcg cgugaccaag     1860

cugcggcucg ggggcccgaa ccaggaccug acgguccugg agaugaagcg cgagaacccc     1920

cagcugaagc agaucgaggg gcucgugaag gagcugcugg agcgggaggg ccucaccgcg     1980

gccgggaaga ucgagaucaa gaucgugcgc cccugggccg agggcaccga ggagggcgcc     2040

cgguggcuga ccgacgagga cacgcgcaac cugaaggaga ucuucuucaa cauccucguc     2100

cccggggcgg aggaggccca gaaggagcgc cagcggcaga aggagcugga guccaacuac     2160

cgccgggugu ggggcagccc cgggggcgag gggaccggcg accuggacga guucgacuuc     2220

uga                                                                   2223


<210>  2949
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OS-9__Homo_sapiens__BAH13933

<400>  2949
auggccgucg agacccuccu cuccucccuc cucggccucc uccuccucgg ccuccuccuc       60

cccgccuccc ucaccggcgg cgucggcucc cucaaccucg aggagcucuc cgagaugcgc      120

uacggcaucg agauccuccc ccuccccguc augggcggcc agucccaguc cuccgacguc      180

gucaucgucu ccuccaagua caagcagcgc uacgagugcc gccuccccgc cggcgccauc      240

cacuuccagc gcgagcgcga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cuccucuccc ccaugcgcga cgcccccugc cuccucaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggc      420

gagguccucu accucggcua cuaccagucc gccuucgacu gggacgacga gaccgccaag      480

gccuccaagc agcaccgccu caagcgcuac cacucccaga ccuacggcaa cggcuccaag      540

ugcgaccuca acggccgccc ccgcgaggcc gagguccgcu uccucugcga cgagggcgcc      600

ggcaucuccg gcgacuacau cgaccgcguc gacgagcccc ucuccugcuc cuacguccuc      660

accauccgca ccccccgccu cugcccccac ccccuccucc gccccccccc cuccgccgcc      720

ccccaggcca uccucugcca ccccucccuc cagcccgagg aguacauggc cuacguccag      780

cgccaggccg acuccaagca guacggcgac aagaucaucg aggagcucca ggaccucggc      840

ccccaggucu gguccgagac caaguccggc gucgcccccc agaagauggc cggccgcacc      900

cucuuccacc ucuuccgcga gauccacuuc cacuucuucc ccucccccga ccucaccguc      960

cucaccgacu gguggggcgg cggcggcguc gagaaguacc acggccccuc cucccucggc     1020

gaccgcggcg gcgagggcac ccccuccuac cuccuccccu ccgucucccc ccuccucucc     1080

gaccaguccc uccccguccu cugcacccuc ggcgccuccc ccaccaagga cgacuccaag     1140

gacuccgacu ucuggaagau gcucaacgag cccgaggacc aggcccccgg cggcgaggag     1200

guccccgccg aggagcagga ccccuccccc gaggccgccg acuccgccuc cggcgccccc     1260

aacgacuucc agaacaacgu ccaggucaag gucauccgcu cccccgccga ccucauccgc     1320

uucaucgagg agcucaaggg cggcaccaag aagggcaagc ccaacaucgg ccaggagcag     1380

cccgucgacg acgccgccga ggucccccag cgcgagcccg agaaggagcg cggcgacccc     1440

gagcgccagc gcgagaugga ggaggaggag gacgaggacg aggacgagga cgaggacgag     1500

gacgagcgcc agcuccucgg cgaguucgag aaggagcucg agggcauccu ccuccccucc     1560

gaccgcgacc gccuccgcuc cgaggucaag gccggcaugg agcgcgagcu cgagaacauc     1620

auccaggaga ccgagaagga gcucgacccc gacggccuca agaaggaguc cgagcgcgac     1680

cgcgccaugc ucgcccucac cuccacccuc aacaagcuca ucaagcgccu cgaggagaag     1740

cagucccccg agcucgucaa gaagcacaag aagaagcgcg ucguccccaa gaagcccccc     1800

cccucccccc agcccaccga ggaggacccc gagcaccgcg uccgcguccg cgucaccaag     1860

cuccgccucg gcggccccaa ccaggaccuc accguccucg agaugaagcg cgagaacccc     1920

cagcucaagc agaucgaggg ccucgucaag gagcuccucg agcgcgaggg ccucaccgcc     1980

gccggcaaga ucgagaucaa gaucguccgc cccugggccg agggcaccga ggagggcgcc     2040

cgcuggcuca ccgacgagga cacccgcaac cucaaggaga ucuucuucaa cauccucguc     2100

cccggcgccg aggaggccca gaaggagcgc cagcgccaga aggagcucga guccaacuac     2160

cgccgcgucu ggggcucccc cggcggcgag ggcaccggcg accucgacga guucgacuuc     2220

uga                                                                   2223


<210>  2950
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OS-9__Homo_sapiens__BAH13933

<400>  2950
auggccgugg agacccugcu cagcucccuu cugggcuugu uacugcuagg gcuccugcuu       60

cccgcuucuc ugacaggagg ugucggcuca uugaaccucg aagaacugag ugaaaugaga      120

uacgggaucg agauucugcc ucucccaguu augggaggcc agagccaauc cucugacgug      180

guaauagugu cgucaaagua uaaacagagg uacgaaugcc gguuaccggc cggugcaauc      240

cacuuccagc gcgagcgaga ggaagagacu cccgcguauc aggggccugg cauuccagaa      300

cugcuuagcc ccaugcguga ugcuccuugu uugcugaaga cgaaagacug guggaccuac      360

gaguuuugcu auggaagaca uauccaacag uaccacaugg aggauaguga aauuaagggc      420

gagguccuau aucucgggua cuaccagucc gccuucgacu gggaugacga aacagcaaaa      480

gccucuaagc agcauaggcu gaagcgguau cacagccaaa cuuacggaaa ugguuccaaa      540

ugugaucuua acggccgccc aagagaggcu gaagugaggu uucugugcga cgagggggca      600

ggaaucucag gcgauuauau agaccggguu gaugagcccu ugaguuguag cuacgugcuc      660

accauccgca caccucgacu gugcccacau ccguuacuga gacccccucc aucugccgcu      720

ccccaggcca uucucuguca cccuucccuu cagccagaag aguauauggc guacguccag      780

aggcaagcag acucaaagca guauggugau aaaaucauug aggagcugca ggacuugggg      840

ccccaagugu ggagcgaaac caagagugga guagccccgc agaaaauggc uggccggacu      900

cuauuccacc uguuucguga gauccauuuc cacuuuuucc cuucucccga ccucacaguu      960

cugaccgauu gguggggcgg gggaggugug gagaaguacc auggcccauc cagccuuggg     1020

gaccgcggag gcgaagguac gccuucguac cuguugcccu cugucucccc acuccuguca     1080

gaucagaguu uacccgugcu gugcacucua ggggccagcc cuaccaagga cgauuccaaa     1140

gacucugauu uuuggaagau gcucaaugag ccagaagacc aggcaccggg cggagaggaa     1200

gugcccgcug aggagcaaga uccuagccca gaagccgcgg acucagccag uggcgcaccc     1260

aacgauuucc agaauaacgu ccagguuaaa gugauaagau ccccugcuga ccugauuagg     1320

uuuaucgagg aacuuaaagg gggaacaaag aaggguaaac caaauauugg ccaggagcaa     1380

cccguagacg augccgcuga ggugccgcag cgggaaccug agaaggaacg aggggaccca     1440

gagcgccaga gagaaaugga ggaggaagag gaugaagacg aggaugaaga cgaggaugag     1500

gacgaaaggc aguugcuggg agaguucgaa aaggagcucg aaggcauccu gcuucccagc     1560

gaucgggacc gccugagauc ugaggucaaa gccgguaugg agagggaauu ggagaacauc     1620

auucaagaaa cugagaagga gcucgauccu gacgggcuga aaaaggaauc agagcgugau     1680

cgggcaaugu uagcccugac caguacacua aauaaacuca uaaagcgacu ggaagagaag     1740

cagagccccg aacuugugaa aaagcacaaa aagaaaagag uugugccaaa gaagccuccc     1800

ccauccccgc agccuaccga ggaggacccc gaacacaggg uccgcgugcg gguaacgaaa     1860

uugagacugg gcggaccaaa ccaggaccuc acuguucugg agaugaagag ggaaaauccc     1920

caauuaaaac agaucgaggg ccuggugaag gaacuuuugg agcgcgaggg gcucacagcu     1980

gcgggaaaaa uugaaaucaa gauaguccga ccuugggcag aggguaccga agagggcgcc     2040

cgguggcuga cugaugaaga cacacguaac cuaaaggaga uuuucuucaa uauccuggug     2100

ccaggggcug aggaagccca gaaagagaga caaaggcaga aggaacucga gucuaacuau     2160

cgccgggucu ggggaucgcc cggcggugag gggaccggcg aucuggacga auuugauuuu     2220

uga                                                                   2223


<210>  2951
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OS-9__Homo_sapiens__BAH13933

<400>  2951
auggccgugg agacccugcu gagcagccug cugggccugc ugcugcuggg ccugcugcug       60

cccgccagcc ugaccggcgg cgugggcagc cugaaccugg aggagcugag cgagaugaga      120

uacggcaucg agauccugcc ccugcccgug augggcggcc agagccagag cagcgacgug      180

gugaucguga gcagcaagua caagcagaga uacgagugca gacugcccgc cggcgccauc      240

cacuuccaga gagagagaga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cugcugagcc ccaugagaga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggcagaca cauccagcag uaccacaugg aggacagcga gaucaagggc      420

gaggugcugu accugggcua cuaccagagc gccuucgacu gggacgacga gaccgccaag      480

gccagcaagc agcacagacu gaagagauac cacagccaga ccuacggcaa cggcagcaag      540

ugcgaccuga acggcagacc cagagaggcc gaggugagau uccugugcga cgagggcgcc      600

ggcaucagcg gcgacuacau cgacagagug gacgagcccc ugagcugcag cuacgugcug      660

accaucagaa cccccagacu gugcccccac ccccugcuga gacccccccc cagcgccgcc      720

ccccaggcca uccugugcca ccccagccug cagcccgagg aguacauggc cuacgugcag      780

agacaggccg acagcaagca guacggcgac aagaucaucg aggagcugca ggaccugggc      840

ccccaggugu ggagcgagac caagagcggc guggcccccc agaagauggc cggcagaacc      900

cuguuccacc uguucagaga gauccacuuc cacuucuucc ccagccccga ccugaccgug      960

cugaccgacu gguggggcgg cggcggcgug gagaaguacc acggccccag cagccugggc     1020

gacagaggcg gcgagggcac ccccagcuac cugcugccca gcgugagccc ccugcugagc     1080

gaccagagcc ugcccgugcu gugcacccug ggcgccagcc ccaccaagga cgacagcaag     1140

gacagcgacu ucuggaagau gcugaacgag cccgaggacc aggcccccgg cggcgaggag     1200

gugcccgccg aggagcagga ccccagcccc gaggccgccg acagcgccag cggcgccccc     1260

aacgacuucc agaacaacgu gcaggugaag gugaucagaa gccccgccga ccugaucaga     1320

uucaucgagg agcugaaggg cggcaccaag aagggcaagc ccaacaucgg ccaggagcag     1380

cccguggacg acgccgccga ggugccccag agagagcccg agaaggagag aggcgacccc     1440

gagagacaga gagagaugga ggaggaggag gacgaggacg aggacgagga cgaggacgag     1500

gacgagagac agcugcuggg cgaguucgag aaggagcugg agggcauccu gcugcccagc     1560

gacagagaca gacugagaag cgaggugaag gccggcaugg agagagagcu ggagaacauc     1620

auccaggaga ccgagaagga gcuggacccc gacggccuga agaaggagag cgagagagac     1680

agagccaugc uggcccugac cagcacccug aacaagcuga ucaagagacu ggaggagaag     1740

cagagccccg agcuggugaa gaagcacaag aagaagagag uggugcccaa gaagcccccc     1800

cccagccccc agcccaccga ggaggacccc gagcacagag ugagagugag agugaccaag     1860

cugagacugg gcggccccaa ccaggaccug accgugcugg agaugaagag agagaacccc     1920

cagcugaagc agaucgaggg ccuggugaag gagcugcugg agagagaggg ccugaccgcc     1980

gccggcaaga ucgagaucaa gaucgugaga cccugggccg agggcaccga ggagggcgcc     2040

agauggcuga ccgacgagga caccagaaac cugaaggaga ucuucuucaa cauccuggug     2100

cccggcgccg aggaggccca gaaggagaga cagagacaga aggagcugga gagcaacuac     2160

agaagagugu ggggcagccc cggcggcgag ggcaccggcg accuggacga guucgacuuc     2220

uga                                                                   2223


<210>  2952
<211>  2223
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OS-9__Homo_sapiens__BAH13933

<400>  2952
auggccgugg agacccugcu cagcucccug cuuggccugc uccugcuugg gcugcuccug       60

cccgcuucuc ugacaggagg cgucgggagc cucaaccugg aagaacuuuc cgaaaugaga      120

uacggaaucg agauucugcc ucucccgguu augggcgggc agucucaaag cuccgacgug      180

gugaucgucu cuagcaagua uaaacagcgg uacgaaugcc gccugcccgc cggagcgauu      240

cacuuccaga gagagcggga ggaagagacg ccugcuuauc agggccccgg caucccugaa      300

cuucuguccc ccaugcgcga ugccccuugu cuccugaaga ccaaagacug guggacauac      360

gaguuuugcu augggagaca uauucaacag uaccacaugg aggauagcga aaucaaggga      420

gaggugcugu aucucggcua cuaccagucu gccuucgacu gggaugacga aaccgcuaaa      480

gccuccaagc agcaucggcu gaagcgcuau cacagccaaa cauacgggaa uggaucuaaa      540

ugugaucuua acggcagacc gcgggaggcu gaaguucgcu uucugugcga cgagggggcc      600

ggaaucuccg gcgauuauau ugacagagug gaugagcccc ucagcuguuc uuacguccug      660

accauccgga caccucgccu uugcccccau ccucugcuca gacccccgcc uuccgcggcu      720

ccccaggcca uucuguguca cccuagccug cagcccgaag aguauauggc cuacgugcag      780

cggcaagcug acuccaagca guauggcgau aaaaucauug aggagcucca ggaccugggg      840

ccccaaguuu ggucugaaac caagagcgga guggccccuc agaaaauggc gggccgcacg      900

cuuuuccacc uguuuagaga gauccauuuc cacuuuuucc cgucccccga ccucaccguc      960

cugacagauu gguggggagg gggcggggug gagaaguacc auggaccuag cucucuuggc     1020

gaccggggcg gggaaggaac ccccuccuac cugcucccua gcgugucucc ccugcugagc     1080

gaucaguccc ucccgguccu gugcacacuu ggcgccucuc cuaccaagga cgauagcaaa     1140

gacuccgauu uuuggaagau gcugaaugag cccgaagacc aggcuccugg gggagaggaa     1200

guucccgccg aggagcaaga uccuagcccc gaagcugccg acucugccuc cggcgcuccg     1260

aacgauuucc agaauaacgu ccaggugaaa gugauuagaa gcccugcgga ccucauccgc     1320

uuuaucgagg aacugaaagg gggcacgaag aagggaaaac ccaauauugg ccaggagcaa     1380

cccguggacg augccgcuga gguuccucag cgggaaccgg agaaggaaag aggggacccc     1440

gagcgccagc gggaaaugga ggaggaagag gaugaagacg aggaugaaga cgaggaugag     1500

gacgaaagac agcugcuugg agaguucgaa aaggagcucg aaggcauccu gcugccuucu     1560

gaucgcgacc ggcucagauc cgaggugaaa gccgggaugg agcgcgaacu ggagaacauu     1620

auccaagaaa cagagaagga gcuugauccc gacggacuga aaaaggaaag cgagcgggau     1680

agagccaugc ucgcucugac cuccacacug aauaaacuua uuaagcgccu cgaagagaag     1740

cagucuccug aacuggucaa aaagcacaaa aagaaacggg ugguucccaa gaagccuccc     1800

ccgagcccuc agcccaccga ggaggacccu gaacacagag ugcggguccg cgugaccaaa     1860

cugagacucg gcgggcccaa ccaggaccug acaguccuug agaugaagcg ggaaaauccg     1920

caacugaaac agaucgaggg ccucgugaag gaacugcugg agagagaggg acuuacggcc     1980

gcgggcaaaa ucgaaauuaa gaucguucgc ccuugggcug aggggaccga agagggagcc     2040

cgguggcuca cagaugaaga caccagaaac cugaaggaga uuuucuucaa uauccuggug     2100

cccggcgccg aggaagcuca gaaagagcgc caaagacaga aggaacucga guccaacuau     2160

cggcgcgucu gggggucucc uggaggcgag gggacaggcg aucuggacga auuugauuuu     2220

uga                                                                   2223


<210>  2953
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__Q13438

<400>  2953

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
    450                 455                 460                 


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
                485                 490                 495     


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
            500                 505                 510         


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
        515                 520                 525             


Ser Pro Gln Pro Thr Glu Glu Asp Pro Glu His Arg Val Arg Val Arg 
    530                 535                 540                 


Val Thr Lys Leu Arg Leu Gly Gly Pro Asn Gln Asp Leu Thr Val Leu 
545                 550                 555                 560 


Glu Met Lys Arg Glu Asn Pro Gln Leu Lys Gln Ile Glu Gly Leu Val 
                565                 570                 575     


Lys Glu Leu Leu Glu Arg Glu Gly Leu Thr Ala Ala Gly Lys Ile Glu 
            580                 585                 590         


Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg 
        595                 600                 605             


Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn 
    610                 615                 620                 


Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln 
625                 630                 635                 640 


Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly 
                645                 650                 655     


Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
            660                 665         


<210>  2954
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OS-9__Homo_sapiens__AAB06495

<400>  2954
auggcggcgg aaacgcugcu guccaguuug uuaggacugc ugcuucuggg acuccuguua       60

cccgcaaguc ugaccggcgg ugucgggagc cugaaccugg aggagcugag ugagaugcgu      120

uaugggaucg agauccugcc guugccuguc augggagggc agagccaauc uucggacgug      180

gugauugucu ccucuaagua caaacagcgc uaugaguguc gccugccagc uggagcuauu      240

cacuuccagc gugaaaggga ggaggaaaca ccugcuuacc aagggccugg gaucccugag      300

uuguugagcc caaugagaga ugcucccugc uugcugaaga caaaggacug guggacauau      360

gaauucuguu auggacgcca cauccagcaa uaccacaugg aagauucaga gaucaaaggu      420

gaaguccucu aucucggcua cuaccaauca gccuucgacu gggaugauga aacagccaag      480

gccuccaagc agcaucgucu uaaacgcuac cacagccaga ccuauggcaa uggguccaag      540

ugcgaccuua augggaggcc ccgggaggcc gagguucggu uccucuguga cgagggugca      600

gguaucucug gggacuacau cgaucgcgug gacgagcccu uguccugcuc uuaugugcug      660

accauucgca cuccucggcu cugcccccac ccucuccucc ggcccccacc cagugcugca      720

ccacaggcca uccucuguca cccuucccua cagccugagg aguacauggc cuacguucag      780

aggcaagccg acucaaagca guauggagau aaaaucauag aggagcugca agaucuaggc      840

ccccaagugu ggagugagac caagucuggg guggcacccc aaaagauggc aggugcgagc      900

ccgaccaagg augacaguaa ggacucagau uucuggaaga ugcuuaauga gccagaggac      960

caggccccag gaggggagga ggugccggcu gaggagcagg acccaagccc ugaggcagca     1020

gauucagcuu cuggugcucc caaugauuuu cagaacaacg ugcaggucaa agucauucga     1080

agcccugcgg auuugauucg auucauagag gagcugaaag guggaacaaa aaaggggaag     1140

ccaaauauag gccaagagca gccuguggau gaugcugcag aagucccuca gagggaacca     1200

gagaaggaaa ggggugaucc agaacggcag agagagaugg aagaagagga ggaugaggau     1260

gaggaugagg augaagauga ggaugaacgg caguuacugg gagaauuuga gaaggaacug     1320

gaagggaucc ugcuuccguc agaccgagac cggcuccguu cggaggugaa ggcuggcaug     1380

gagcgggaac uggagaacau cauccaggag acagagaaag agcuggaccc agaugggcug     1440

aagaaggagu cagagcggga ucgggcaaug cuggcucuca cauccacucu caacaaacuc     1500

aucaaaagac uggaggaaaa acagagucca gagcugguga agaagcacaa gaaaaagagg     1560

guugucccca aaaagccucc cccaucaccc caaccuacag aggaggaucc ugagcacaga     1620

guccgggucc gggucaccaa gcuccgucuc ggaggcccua aucaggaucu gacuguccuc     1680

gagaugaaac gggaaaaccc acagcugaaa caaaucgagg ggcuggugaa ggagcugcug     1740

gagagggagg gacucacagc ugcagggaaa auugagauca aaauuguccg cccaugggcu     1800

gaagggacug aagagggugc acguuggcug acugaugagg acacgagaaa ccucaaggag     1860

aucuucuuca auaucuuggu gccgggagcu gaagaggccc agaaggaacg ccagcggcag     1920

aaagagcugg agagcaauua ccgccgggug uggggcucuc caggugggga gggcacaggg     1980

gaccuggacg aauuugacuu cuga                                            2004


<210>  2955
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OS-9__Homo_sapiens__AAB06495

<400>  2955
auggccgccg agacccugcu cagcucccug cugggccucc ugcugcucgg gcugcugcuc       60

cccgcgagcc ugaccggcgg ggugggcucc cugaaccucg aggagcugag cgagaugcgc      120

uacgggaucg agauccugcc gcuccccguc augggcggcc agucccagag cuccgacgug      180

gugaucguca gcuccaagua caagcagcgg uacgagugcc gccugcccgc cggggccauc      240

cacuuccagc gggagcgcga ggaggagacg cccgccuacc agggcccggg gauccccgag      300

cugcucagcc ccaugcggga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggg      420

gaggugcucu accugggcua cuaccagagc gcguucgacu gggacgacga gaccgccaag      480

gccuccaagc agcaccggcu gaagcgcuac cacagccaga cguacggcaa cggguccaag      540

ugcgaccuca acggccggcc gcgcgaggcc gaggugcggu uccugugcga cgagggggcg      600

ggcaucagcg gcgacuacau cgaccgcguc gacgagcccc uguccugcag cuacgugcuc      660

accauccgga cgccccgccu gugcccccac ccgcugcucc ggcccccgcc cuccgccgcg      720

ccccaggcca uccugugcca ccccagccug cagcccgagg aguacauggc cuacgugcag      780

cgccaggccg acagcaagca guacggggac aagaucaucg aggagcucca ggaccugggc      840

ccccaggucu gguccgagac caagagcggg guggccccgc agaagauggc cggcgccucc      900

cccaccaagg acgacagcaa ggacuccgac uucuggaaga ugcugaacga gcccgaggac      960

caggcccccg ggggcgagga ggugccggcg gaggagcagg accccagccc cgaggccgcc     1020

gacuccgcca gcggcgcccc caacgacuuc cagaacaacg uccaggugaa ggugauccgg     1080

uccccggcgg accucauccg cuucaucgag gagcugaagg gcgggaccaa gaaggggaag     1140

cccaacaucg gccaggagca gcccgucgac gacgccgccg aggugccgca gcgggagccc     1200

gagaaggagc gcggggaccc cgagcggcag cgcgagaugg aggaggagga ggacgaggac     1260

gaggacgagg acgaggacga ggacgagcgc cagcugcucg gcgaguucga gaaggagcug     1320

gagggcaucc ugcuccccag cgaccgggac cgccugcggu ccgaggugaa ggccgggaug     1380

gagcgcgagc uggagaacau cauccaggag accgagaagg agcucgaccc ggacggccug     1440

aagaaggaga gcgagcggga ccgcgccaug cuggcgcuca ccuccacgcu gaacaagcug     1500

aucaagcggc uggaggagaa gcagagcccc gagcucguca agaagcacaa gaagaagcgc     1560

guggugccca agaagccccc gcccagcccc cagcccaccg aggaggaccc ggagcaccgg     1620

guccgcgugc gggugaccaa gcugcgccuc gggggcccca accaggaccu gaccguccug     1680

gagaugaagc gggagaaccc ccagcugaag cagaucgagg ggcucgugaa ggagcugcug     1740

gagcgcgagg gccucacggc cgccggcaag aucgagauca agaucguccg gcccugggcc     1800

gaggggaccg aggagggcgc gcgcuggcug accgacgagg acacccggaa ccugaaggag     1860

aucuucuuca acauccucgu gccgggggcc gaggaggccc agaaggagcg ccagcggcag     1920

aaggagcugg aguccaacua ccgccgcgug uggggcuccc ccggcgggga gggcacgggg     1980

gaccuggacg aguucgacuu cuga                                            2004


<210>  2956
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OS-9__Homo_sapiens__AAB06495

<400>  2956
auggccgccg agacccuccu cuccucccuc cucggccucc uccuccucgg ccuccuccuc       60

cccgccuccc ucaccggcgg cgucggcucc cucaaccucg aggagcucuc cgagaugcgc      120

uacggcaucg agauccuccc ccuccccguc augggcggcc agucccaguc cuccgacguc      180

gucaucgucu ccuccaagua caagcagcgc uacgagugcc gccuccccgc cggcgccauc      240

cacuuccagc gcgagcgcga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cuccucuccc ccaugcgcga cgcccccugc cuccucaaga ccaaggacug guggaccuac      360

gaguucugcu acggccgcca cauccagcag uaccacaugg aggacuccga gaucaagggc      420

gagguccucu accucggcua cuaccagucc gccuucgacu gggacgacga gaccgccaag      480

gccuccaagc agcaccgccu caagcgcuac cacucccaga ccuacggcaa cggcuccaag      540

ugcgaccuca acggccgccc ccgcgaggcc gagguccgcu uccucugcga cgagggcgcc      600

ggcaucuccg gcgacuacau cgaccgcguc gacgagcccc ucuccugcuc cuacguccuc      660

accauccgca ccccccgccu cugcccccac ccccuccucc gccccccccc cuccgccgcc      720

ccccaggcca uccucugcca ccccucccuc cagcccgagg aguacauggc cuacguccag      780

cgccaggccg acuccaagca guacggcgac aagaucaucg aggagcucca ggaccucggc      840

ccccaggucu gguccgagac caaguccggc gucgcccccc agaagauggc cggcgccucc      900

cccaccaagg acgacuccaa ggacuccgac uucuggaaga ugcucaacga gcccgaggac      960

caggcccccg gcggcgagga gguccccgcc gaggagcagg accccucccc cgaggccgcc     1020

gacuccgccu ccggcgcccc caacgacuuc cagaacaacg uccaggucaa ggucauccgc     1080

ucccccgccg accucauccg cuucaucgag gagcucaagg gcggcaccaa gaagggcaag     1140

cccaacaucg gccaggagca gcccgucgac gacgccgccg agguccccca gcgcgagccc     1200

gagaaggagc gcggcgaccc cgagcgccag cgcgagaugg aggaggagga ggacgaggac     1260

gaggacgagg acgaggacga ggacgagcgc cagcuccucg gcgaguucga gaaggagcuc     1320

gagggcaucc uccuccccuc cgaccgcgac cgccuccgcu ccgaggucaa ggccggcaug     1380

gagcgcgagc ucgagaacau cauccaggag accgagaagg agcucgaccc cgacggccuc     1440

aagaaggagu ccgagcgcga ccgcgccaug cucgcccuca ccuccacccu caacaagcuc     1500

aucaagcgcc ucgaggagaa gcaguccccc gagcucguca agaagcacaa gaagaagcgc     1560

gucgucccca agaagccccc ccccuccccc cagcccaccg aggaggaccc cgagcaccgc     1620

guccgcgucc gcgucaccaa gcuccgccuc ggcggcccca accaggaccu caccguccuc     1680

gagaugaagc gcgagaaccc ccagcucaag cagaucgagg gccucgucaa ggagcuccuc     1740

gagcgcgagg gccucaccgc cgccggcaag aucgagauca agaucguccg ccccugggcc     1800

gagggcaccg aggagggcgc ccgcuggcuc accgacgagg acacccgcaa ccucaaggag     1860

aucuucuuca acauccucgu ccccggcgcc gaggaggccc agaaggagcg ccagcgccag     1920

aaggagcucg aguccaacua ccgccgcguc uggggcuccc ccggcggcga gggcaccggc     1980

gaccucgacg aguucgacuu cuga                                            2004


<210>  2957
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OS-9__Homo_sapiens__AAB06495

<400>  2957
auggccgcug agacccugcu cagcucccuu cugggcuugu uacugcuagg gcuccugcuu       60

cccgcaucuc ugacaggagg ugugggcuca uugaaccucg aagaacugag ugaaaugaga      120

uacgggaucg agauucugcc ucucccaguc augggaggcc agagccaauc cucugacguu      180

gugauaguau cgucaaagua uaaacagagg uacgaaugcc gguuaccggc cggugcgauc      240

cacuuccagc gcgagcgaga ggaagagacu cccgcuuauc aggggccugg gauuccagaa      300

cugcuuagcc ccaugcguga ugccccuugu uugcugaaga cgaaagacug guggaccuac      360

gaguuuugcu auggcagaca uauccaacag uaccacaugg aggauaguga aauuaagggc      420

gaggugcuau aucucgggua cuaccagucc gcauucgacu gggaugacga aacagccaaa      480

gccucuaagc agcauaggcu gaagcgguau cacagccaaa cuuacggaaa ugguuccaaa      540

ugugaucuua acggccgccc aagagaggca gaagucaggu uucugugcga cgagggggcc      600

ggaaucucag gcgauuauau agaccgggug gaugagcccu ugaguuguag cuacguucuc      660

accauccgca caccucgacu gugcccacau ccguuacuga gacccccucc aucugcugcu      720

ccccaggcga uucucuguca cccuucccuu cagccagaag aguauauggc auacgugcag      780

aggcaagccg acucaaagca guauggugau aaaaucauug aagaacugca ggacuugggg      840

ccccaagucu ggagcgaaac caagagugga guggcuccgc agaaaauggc cggcgcaucu      900

ccuacuaagg acgauuccaa ggacagcgau uucuggaaaa ugcuaaauga gcccgaggac      960

caggcuccag gcggggaaga gguaccugcc gaggagcagg aucccucgcc agaagcggcc     1020

gacucugcau ccggagcucc caacgauuuu caaaauaacg uucaggugaa ggucauccgg     1080

aguccugccg accugauacg uuucauugag gagcucaaag guggcacaaa gaaagggaag     1140

ccaaauaucg gacaggaaca gccgguggau gacgcugccg aggugcccca acgcgaaccu     1200

gagaaagaga gaggcgaucc agaaaggcag cgggagaugg aagaggaaga ggacgaggac     1260

gaagaugagg acgaagauga ggacgaacga cagcugcuug gugaguuuga gaaggaacug     1320

gaggggauuu ugcuccccuc agaucgcgac agacugagga gcgaagucaa ggcaggcaug     1380

gagcgggaau uagagaacau cauccaggag accgaaaaag agcuggaucc ugacggacua     1440

aagaaagaau ccgagcgcga uagagccaug cucgcucuga cgucuacucu uaauaaguug     1500

auuaaaaggc uggaggaaaa gcaaagccca gagcucguua agaaacacaa gaaaaagcgu     1560

gugguaccca aaaagccgcc uccaucaccc cagccuaccg aagaggaccc cgaacaucgg     1620

gugcgaguca gagugacaaa gcugaggcuu ggcgggccaa accaggaucu gacuguuuug     1680

gagaugaaac gcgagaaucc ucagcucaag caaauagaag gacuggugaa agaguuacug     1740

gaacgggagg gucuaaccgc ggcaggcaag aucgaaauua aaaucgucag acccugggcc     1800

gaggggacag aggaaggagc uagguggcuc accgacgagg auacgcgcaa ccugaaggaa     1860

auauucuuua auauucuugu gccaggcgcc gaggaagcac agaaggagcg acagcggcaa     1920

aaagaguugg aaaguaacua ccguagagua ugggguuccc cgggaggcga gggaacuggc     1980

gaccuggacg aguucgauuu uuga                                            2004


<210>  2958
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OS-9__Homo_sapiens__AAB06495

<400>  2958
auggccgccg agacccugcu gagcagccug cugggccugc ugcugcuggg ccugcugcug       60

cccgccagcc ugaccggcgg cgugggcagc cugaaccugg aggagcugag cgagaugaga      120

uacggcaucg agauccugcc ccugcccgug augggcggcc agagccagag cagcgacgug      180

gugaucguga gcagcaagua caagcagaga uacgagugca gacugcccgc cggcgccauc      240

cacuuccaga gagagagaga ggaggagacc cccgccuacc agggccccgg cauccccgag      300

cugcugagcc ccaugagaga cgcccccugc cugcugaaga ccaaggacug guggaccuac      360

gaguucugcu acggcagaca cauccagcag uaccacaugg aggacagcga gaucaagggc      420

gaggugcugu accugggcua cuaccagagc gccuucgacu gggacgacga gaccgccaag      480

gccagcaagc agcacagacu gaagagauac cacagccaga ccuacggcaa cggcagcaag      540

ugcgaccuga acggcagacc cagagaggcc gaggugagau uccugugcga cgagggcgcc      600

ggcaucagcg gcgacuacau cgacagagug gacgagcccc ugagcugcag cuacgugcug      660

accaucagaa cccccagacu gugcccccac ccccugcuga gacccccccc cagcgccgcc      720

ccccaggcca uccugugcca ccccagccug cagcccgagg aguacauggc cuacgugcag      780

agacaggccg acagcaagca guacggcgac aagaucaucg aggagcugca ggaccugggc      840

ccccaggugu ggagcgagac caagagcggc guggcccccc agaagauggc cggcgccagc      900

cccaccaagg acgacagcaa ggacagcgac uucuggaaga ugcugaacga gcccgaggac      960

caggcccccg gcggcgagga ggugcccgcc gaggagcagg accccagccc cgaggccgcc     1020

gacagcgcca gcggcgcccc caacgacuuc cagaacaacg ugcaggugaa ggugaucaga     1080

agccccgccg accugaucag auucaucgag gagcugaagg gcggcaccaa gaagggcaag     1140

cccaacaucg gccaggagca gcccguggac gacgccgccg aggugcccca gagagagccc     1200

gagaaggaga gaggcgaccc cgagagacag agagagaugg aggaggagga ggacgaggac     1260

gaggacgagg acgaggacga ggacgagaga cagcugcugg gcgaguucga gaaggagcug     1320

gagggcaucc ugcugcccag cgacagagac agacugagaa gcgaggugaa ggccggcaug     1380

gagagagagc uggagaacau cauccaggag accgagaagg agcuggaccc cgacggccug     1440

aagaaggaga gcgagagaga cagagccaug cuggcccuga ccagcacccu gaacaagcug     1500

aucaagagac uggaggagaa gcagagcccc gagcugguga agaagcacaa gaagaagaga     1560

guggugccca agaagccccc ccccagcccc cagcccaccg aggaggaccc cgagcacaga     1620

gugagaguga gagugaccaa gcugagacug ggcggcccca accaggaccu gaccgugcug     1680

gagaugaaga gagagaaccc ccagcugaag cagaucgagg gccuggugaa ggagcugcug     1740

gagagagagg gccugaccgc cgccggcaag aucgagauca agaucgugag acccugggcc     1800

gagggcaccg aggagggcgc cagauggcug accgacgagg acaccagaaa ccugaaggag     1860

aucuucuuca acauccuggu gcccggcgcc gaggaggccc agaaggagag acagagacag     1920

aaggagcugg agagcaacua cagaagagug uggggcagcc ccggcggcga gggcaccggc     1980

gaccuggacg aguucgacuu cuga                                            2004


<210>  2959
<211>  2004
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OS-9__Homo_sapiens__AAB06495

<400>  2959
auggccgcug agacccugcu cagcucccug cuuggccugc uccugcuugg gcugcuccug       60

cccgccucuc ugacaggagg cguggggagc cucaaccugg aagaacuuuc cgaaaugaga      120

uacggaaucg agauucugcc ucucccgguc augggcgggc agucucaaag cuccgacguu      180

gugaucgugu cuagcaagua uaaacagcgg uacgaaugcc gccugcccgc gggagcuauu      240

cacuuccaga gagagcggga ggaagagacg ccugccuauc agggccccgg caucccugaa      300

cuucuguccc ccaugcgcga ugccccuugu cuccugaaga ccaaagacug guggacauac      360

gaguuuugcu augggagaca uauucaacag uaccacaugg aggauagcga aaucaaggga      420

gagguccugu aucucggcua cuaccagucu gcuuucgacu gggaugacga aaccgccaag      480

gcuuccaaac agcaucggcu gaagcgcuau cacagccaaa cauacgggaa uggaucuaaa      540

ugugaucuua acggcagacc gcgggaggcc gaagugcgcu uucugugcga cgagggggcg      600

ggaaucuccg gcgauuauau ugacagaguu gaugagcccc ucagcuguuc uuacgugcug      660

accauccgga caccucgccu uugcccccau ccucugcuca gacccccgcc uuccgccgcu      720

ccccaggcca uucuguguca cccuagccug cagcccgaag aguauauggc uuacguccag      780

cggcaagccg acuccaagca guauggcgau aaaaucauug aagaacucca ggaccugggg      840

ccccaagugu ggucugaaac caagagcgga guugcgccuc agaaaauggc cggcgcuucc      900

ccgacgaagg acgauagcaa ggacucugau uucuggaaaa ugcuuaauga gcccgaggac      960

caggccccug ggggagaaga ggugcccgcu gaggagcagg auccuucccc cgaagccgcc     1020

gacagcgcuu cuggcgcgcc gaacgauuuu caaaauaacg uccaggugaa ggugauccgc     1080

agcccugccg accugauuag auucaucgag gagcucaaag ggggaaccaa gaaaggcaag     1140

cccaauaucg gccaggaaca gccugucgau gacgcugccg agguucccca acgggaaccu     1200

gagaaagaga gaggggaucc cgaacgccag cgggagaugg aagaggaaga ggacgaggac     1260

gaagaugagg acgaagauga ggacgaaaga cagcugcuug gagaguuuga gaaggaacug     1320

gagggcauuc uccugccguc cgaucgcgac cggcugagau cugaagugaa ggccgggaug     1380

gagcgcgaac ucgagaacau cauucaggag acagaaaaag agcuggaucc ugacggacuu     1440

aagaaagaaa gcgagcggga uagagcuaug cuggcccuca ccuccacacu gaauaagcug     1500

aucaaacgcc uugaggaaaa gcaaagcccc gagcucguga agaaacacaa gaaaaagcgg     1560

gucgugccca aaaagccucc gcccucuccu cagcccaccg aagaggaccc ugaacauaga     1620

guucgcgugc gggucacgaa gcugagacug ggcgggccca accaggaucu cacagugcug     1680

gagaugaaac gggagaaucc ucagcuuaag caaauugaag gccugguuaa agagcuccug     1740

gaacgcgagg gacugaccgc ggcuggcaag aucgaaauca aaauugugag acccugggcc     1800

gaggggacag aggaaggagc ccgguggcuu accgacgagg auaccagaaa ccucaaggaa     1860

aucuucuuua auauucuggu cccgggcgcu gaggaagccc agaaggagcg ccagcggcaa     1920

aaagagcugg aauccaacua cagacgcgug ugggggagcc cuggaggcga ggggacaggc     1980

gaccucgacg aguucgauuu uuga                                            2004


<210>  2960
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteocalcin__Homo_sapiens__P02818

<400>  2960

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  2961
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteocalcin__Homo_sapiens__AAI13433

<400>  2961
augagagccc ucacacuccu cgcccuauug gcccuggccg cacuuugcau cgcuggccag       60

gcaggugcga agcccagcgg ugcagagucc agcaaaggug cagccuuugu guccaagcag      120

gagggcagcg agguagugaa gagacccagg cgcuaccugu aucaauggcu gggagcccca      180

guccccuacc cggauccccu ggagcccagg agggaggugu gugagcucaa uccggacugu      240

gacgaguugg cugaccacau cggcuuucag gaggccuauc ggcgcuucua cggcccgguc      300

uag                                                                    303


<210>  2962
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteocalcin__Homo_sapiens__AAI13433

<400>  2962
augcgcgccc ugacccuccu ggcccugcuc gcgcuggccg cccugugcau cgccggccag       60

gccggggcga agcccagcgg cgccgagucc agcaaggggg ccgccuucgu guccaagcag      120

gagggcagcg aggucgugaa gcggccgcgc cgguaccucu accaguggcu gggggcgccc      180

gugcccuacc ccgacccgcu ggagccccgc cgggaggucu gcgagcucaa ccccgacugc      240

gacgagcugg ccgaccacau cggcuuccag gaggccuacc gccgguucua cggccccgug      300

uga                                                                    303


<210>  2963
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteocalcin__Homo_sapiens__AAI13433

<400>  2963
augcgcgccc ucacccuccu cgcccuccuc gcccucgccg cccucugcau cgccggccag       60

gccggcgcca agcccuccgg cgccgagucc uccaagggcg ccgccuucgu cuccaagcag      120

gagggcuccg aggucgucaa gcgcccccgc cgcuaccucu accaguggcu cggcgccccc      180

guccccuacc ccgacccccu cgagccccgc cgcgaggucu gcgagcucaa ccccgacugc      240

gacgagcucg ccgaccacau cggcuuccag gaggccuacc gccgcuucua cggccccguc      300

uga                                                                    303


<210>  2964
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteocalcin__Homo_sapiens__AAI13433

<400>  2964
augagagccc ugacccuccu ugcucuguug gcauuagccg cgcugugcau cgcuggccag       60

gccggggcaa agcccagcgg agccgagucc ucuaaaggug cugcauucgu gucaaagcaa      120

gaaggcagug aggucguuaa aaggccucgg cgcuaccuau aucaguggcu cggggcccca      180

gugccguacc ccgacccucu ggaaccacga cgugagguau gugaacuuaa ccccgauugc      240

gacgagcugg cugaucacau uggauuucag gaggccuaua gaagguucua cggcccugug      300

uga                                                                    303


<210>  2965
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteocalcin__Homo_sapiens__AAI13433

<400>  2965
augagagccc ugacccugcu ggcccugcug gcccuggccg cccugugcau cgccggccag       60

gccggcgcca agcccagcgg cgccgagagc agcaagggcg ccgccuucgu gagcaagcag      120

gagggcagcg agguggugaa gagacccaga agauaccugu accaguggcu gggcgccccc      180

gugcccuacc ccgacccccu ggagcccaga agagaggugu gcgagcugaa ccccgacugc      240

gacgagcugg ccgaccacau cggcuuccag gaggccuaca gaagauucua cggccccgug      300

uga                                                                    303


<210>  2966
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteocalcin__Homo_sapiens__AAI13433

<400>  2966
augagagccc ugacccuccu ggcccuucug gcucucgcgg cucugugcau cgccggccag       60

gccggggcua agcccagcgg agccgagucc ucuaaaggcg cugccuucgu gagcaagcaa      120

gaaggguccg aggucguuaa acggccucgc agauaccuuu aucaguggcu gggagcgccg      180

gugcccuacc cugacccccu cgaaccucgg cgcgaggugu gugaacugaa ccccgauugc      240

gacgagcugg ccgaucacau uggcuuucag gaggcuuaua gacgguucua cgggccuguc      300

uga                                                                    303


<210>  2967
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__A0A024RDE2

<400>  2967

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  2968
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__EAX06008

<400>  2968
augagaauug cagugauuug cuuuugccuc cuaggcauca ccugugccau accaguuaaa       60

caggcugauu cuggaaguuc ugaggaaaag cagcuuuaca acaaauaccc agaugcugug      120

gccacauggc uaaacccuga cccaucucag aagcagaauc uccuagcccc acagaaugcu      180

guguccucug aagaaaccaa ugacuuuaaa caagagaccc uuccaaguaa guccaacgaa      240

agccaugacc acauggauga uauggaugau gaagaugaug augaccaugu ggacagccag      300

gacuccauug acucgaacga cucugaugau guagaugaca cugaugauuc ucaccagucu      360

gaugagucuc accauucuga ugaaucugau gaacugguca cugauuuucc cacggaccug      420

ccagcaaccg aaguuuucac uccaguuguc cccacaguag acacauauga uggccgaggu      480

gauagugugg uuuauggacu gaggucaaaa ucuaagaagu uucgcagacc ugacauccag      540

uacccugaug cuacagacga ggacaucacc ucacacaugg aaagcgagga guugaauggu      600

gcauacaagg ccauccccgu ugcccaggac cugaacgcgc cuucugauug ggacagccgu      660

gggaaggaca guuaugaaac gagucagcug gaugaccaga gugcugaaac ccacagccac      720

aagcagucca gauuauauaa gcggaaagcc aaugaugaga gcaaugagca uuccgaugug      780

auugauaguc aggaacuuuc caaagucagc cgugaauucc acagccauga auuucacagc      840

caugaagaua ugcugguugu agaccccaaa aguaaggaag aagauaaaca ccugaaauuu      900

cguauuucuc augaauuaga uagugcaucu ucugagguca auuaa                      945


<210>  2969
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__EAX06008

<400>  2969
augcgcaucg ccgugaucug cuucugccug cucggcauca cgugcgccau ccccgucaag       60

caggcggaca gcggguccag cgaggagaag cagcuguaca acaaguaccc ggacgccgug      120

gccaccuggc ugaaccccga ccccucccag aagcagaacc uccuggcgcc ccagaacgcc      180

gugagcuccg aggagaccaa cgacuucaag caggagaccc ugccgagcaa guccaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu cgacucccag      300

gacagcaucg acuccaacga cagcgacgac guggacgaca ccgacgacuc ccaccagagc      360

gacgaguccc accacagcga cgaguccgac gagcucguga ccgacuuccc cacggaccug      420

cccgccaccg aggucuucac ccccguggug ccgaccgucg acacguacga cggccgcggg      480

gacagcgugg uguacggccu gcgguccaag agcaagaagu uccggcgccc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc agccacaugg aguccgagga gcucaacggg      600

gccuacaagg ccauccccgu cgcgcaggac cugaacgccc cgagcgacug ggacucccgg      660

ggcaaggaca gcuacgagac cucccagcug gacgaccaga gcgccgagac gcacucccac      720

aagcagagcc gccucuacaa gcggaaggcc aacgacgagu ccaacgagca cagcgacgug      780

aucgacuccc aggagcugag caaggugucc cgcgaguucc acagccacga guuccacucc      840

cacgaggaca ugcuggucgu ggaccccaag agcaaggagg aggacaagca ccucaaguuc      900

cggaucuccc acgagcugga cagcgccucc agcgagguga acuga                      945


<210>  2970
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__EAX06008

<400>  2970
augcgcaucg ccgucaucug cuucugccuc cucggcauca ccugcgccau ccccgucaag       60

caggccgacu ccggcuccuc cgaggagaag cagcucuaca acaaguaccc cgacgccguc      120

gccaccuggc ucaaccccga ccccucccag aagcagaacc uccucgcccc ccagaacgcc      180

gucuccuccg aggagaccaa cgacuucaag caggagaccc uccccuccaa guccaacgag      240

ucccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu cgacucccag      300

gacuccaucg acuccaacga cuccgacgac gucgacgaca ccgacgacuc ccaccagucc      360

gacgaguccc accacuccga cgaguccgac gagcucguca ccgacuuccc caccgaccuc      420

cccgccaccg aggucuucac ccccgucguc cccaccgucg acaccuacga cggccgcggc      480

gacuccgucg ucuacggccu ccgcuccaag uccaagaagu uccgccgccc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc ucccacaugg aguccgagga gcucaacggc      600

gccuacaagg ccauccccgu cgcccaggac cucaacgccc ccuccgacug ggacucccgc      660

ggcaaggacu ccuacgagac cucccagcuc gacgaccagu ccgccgagac ccacucccac      720

aagcaguccc gccucuacaa gcgcaaggcc aacgacgagu ccaacgagca cuccgacguc      780

aucgacuccc aggagcucuc caaggucucc cgcgaguucc acucccacga guuccacucc      840

cacgaggaca ugcucgucgu cgaccccaag uccaaggagg aggacaagca ccucaaguuc      900

cgcaucuccc acgagcucga cuccgccucc uccgagguca acuga                      945


<210>  2971
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__EAX06008

<400>  2971
augagaaucg ccgugauuug cuucugucug cucggcauaa ccugcgcuau ccccgucaag       60

caggcagaca gcggguccuc ugaggaaaaa caacuuuaca acaaguaucc ugaugccguu      120

gcgacauggc ugaauccaga cccgucacag aaacagaacu uguuagcucc ccagaaugcc      180

gugaguagcg aggaaacuaa cgauuuuaag caagagacgc ugccuuccaa aucuaaugaa      240

ucgcacgacc auauggauga cauggaugac gaggaugacg augaccacgu agauucacag      300

gacagcauug acaguaacga uuccgacgau guggacgaua ccgacgauuc ucaucagagc      360

gacgaguccc accauucaga ugaaagugac gagcuaguca cagauuuccc aacugaccuc      420

cccgcaaccg aaguguuuac accuguugug ccaaccgucg acacuuacga uggaaggggu      480

gacagcgugg uauauggccu gcggucuaag uccaagaaau uccgccgacc cgauauccag      540

uacccugacg ccacagauga ggacauuacc ucacacaugg agagcgagga acuuaauggg      600

gcuuauaagg caaucccagu ugcccaagau cugaacgcuc cgagugacug ggauucucgu      660

ggaaaagacu ccuacgaaac gagccaguug gaugaccagu cggccgagac ucacucucau      720

aagcagucca gacucuauaa aaggaaggcg aaugaugaau caaacgagca cagugacgug      780

auagacagcc aagagcuguc caaggucucu cgggaauuuc auagccacga guuccacuca      840

caugaagaua ugcugguggu ggaccccaaa aguaaggagg aagauaaaca ccucaaguuu      900

cgcaucuccc augaguuaga cagcgcaucu ucagagguca auuga                      945


<210>  2972
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__EAX06008

<400>  2972
augagaaucg ccgugaucug cuucugccug cugggcauca ccugcgccau ccccgugaag       60

caggccgaca gcggcagcag cgaggagaag cagcuguaca acaaguaccc cgacgccgug      120

gccaccuggc ugaaccccga ccccagccag aagcagaacc ugcuggcccc ccagaacgcc      180

gugagcagcg aggagaccaa cgacuucaag caggagaccc ugcccagcaa gagcaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu ggacagccag      300

gacagcaucg acagcaacga cagcgacgac guggacgaca ccgacgacag ccaccagagc      360

gacgagagcc accacagcga cgagagcgac gagcugguga ccgacuuccc caccgaccug      420

cccgccaccg agguguucac ccccguggug cccaccgugg acaccuacga cggcagaggc      480

gacagcgugg uguacggccu gagaagcaag agcaagaagu ucagaagacc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc agccacaugg agagcgagga gcugaacggc      600

gccuacaagg ccauccccgu ggcccaggac cugaacgccc ccagcgacug ggacagcaga      660

ggcaaggaca gcuacgagac cagccagcug gacgaccaga gcgccgagac ccacagccac      720

aagcagagca gacuguacaa gagaaaggcc aacgacgaga gcaacgagca cagcgacgug      780

aucgacagcc aggagcugag caaggugagc agagaguucc acagccacga guuccacagc      840

cacgaggaca ugcugguggu ggaccccaag agcaaggagg aggacaagca ccugaaguuc      900

agaaucagcc acgagcugga cagcgccagc agcgagguga acuga                      945


<210>  2973
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__EAX06008

<400>  2973
augagaaucg ccgugauuug cuucugucug cucggcauua ccugcgcuau ccccgucaag       60

caggccgaca gcggguccuc ugaggaaaaa caacuguaca acaaguaucc ugaugcgguu      120

gcuacauggc uuaauccgga ccccagccag aaacagaacc ugcucgcccc ucagaaugcc      180

guguccucug aggaaacgaa cgauuuuaag caagagaccc ugcccagcaa auccaaugaa      240

ucucacgacc auauggauga cauggaugac gaggaugacg augaccacgu ggauagccag      300

gacuccaucg acagcaacga uucugacgau gucgacgaua cagacgauuc ccaucagagc      360

gacgagucuc accauuccga ugaaagcgac gagcuuguga ccgauuuccc uacagaccug      420

cccgcuaccg aaguuuuuac accugugguc ccgaccgugg acacguacga uggacggggc      480

gacucuguug uguaugggcu ccgcuccaag agcaagaaau ucagacggcc cgauauucag      540

uacccugacg ccaccgauga ggacaucaca ucccacaugg agucugagga acugaaugga      600

gcuuauaagg ccauccccgu cgcgcaagau cugaacgccc cuagcgacug ggauucccgc      660

ggcaaagaca gcuacgaaac cucucagcuc gaugaccagu ccgcugagac acacagccau      720

aagcagucua gacuguauaa acggaaggcc aaugaugaaa gcaacgagca cuccgacgug      780

auugacucuc aagagcuuag caaggugucc cgcgaauuuc auagccacga guuccacucu      840

caugaagaua ugcuggucgu ugaccccaaa uccaaggagg aagauaaaca ccucaaguuu      900

agaaucagcc augagcugga cucugcuucc agcgagguga auuga                      945


<210>  2974
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__A0A024RDE6

<400>  2974

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  2975
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__EAX06009

<400>  2975
augagaauug cagugauuug cuuuugccuc cuaggcauca ccugugccau accaguuaaa       60

caggcugauu cuggaaguuc ugaggaaaag cagcuuuaca acaaauaccc agaugcugug      120

gccacauggc uaaacccuga cccaucucag aagcagaauc uccuagcccc acagacccuu      180

ccaaguaagu ccaacgaaag ccaugaccac auggaugaua uggaugauga agaugaugau      240

gaccaugugg acagccagga cuccauugac ucgaacgacu cugaugaugu agaugacacu      300

gaugauucuc accagucuga ugagucucac cauucugaug aaucugauga acuggucacu      360

gauuuuccca cggaccugcc agcaaccgaa guuuucacuc caguuguccc cacaguagac      420

acauaugaug gccgagguga uagugugguu uauggacuga ggucaaaauc uaagaaguuu      480

cgcagaccug acauccagua cccugaugcu acagacgagg acaucaccuc acacauggaa      540

agcgaggagu ugaauggugc auacaaggcc auccccguug cccaggaccu gaacgcgccu      600

ucugauuggg acagccgugg gaaggacagu uaugaaacga gucagcugga ugaccagagu      660

gcugaaaccc acagccacaa gcaguccaga uuauauaagc ggaaagccaa ugaugagagc      720

aaugagcauu ccgaugugau ugauagucag gaacuuucca aagucagccg ugaauuccac      780

agccaugaau uucacagcca ugaagauaug cugguuguag accccaaaag uaaggaagaa      840

gauaaacacc ugaaauuucg uauuucucau gaauuagaua gugcaucuuc ugaggucaau      900

uaa                                                                    903


<210>  2976
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__EAX06009

<400>  2976
augcgcaucg ccgugaucug cuucugccug cucggcauca cgugcgccau ccccgucaag       60

caggcggaca gcggguccag cgaggagaag cagcuguaca acaaguaccc ggacgccgug      120

gccaccuggc ugaaccccga ccccucccag aagcagaacc uccuggcgcc ccagacccug      180

ccgagcaagu ccaacgagag ccacgaccac auggacgaca uggacgacga ggacgacgac      240

gaccacgugg acucccagga cagcaucgac uccaacgaca gcgacgacgu cgacgacacc      300

gacgacuccc accagagcga cgagucccac cacagcgacg aguccgacga gcucgugacc      360

gacuucccca ccgaccugcc cgccacggag guguucaccc ccgucgugcc gaccguggac      420

accuacgacg gccgcgggga cagcgucgug uacggccugc gguccaagag caagaaguuc      480

cggcgccccg acauccagua ccccgacgcc acggacgagg acaucaccuc ccacauggag      540

agcgaggagc ucaacggggc cuacaaggcc auccccgugg cccaggaccu gaacgcgccg      600

agcgacuggg acucccgggg caaggacagc uacgagaccu cccagcugga cgaccagagc      660

gccgagaccc acucccacaa gcagagccgc cucuacaagc ggaaggccaa cgacgagucc      720

aacgagcaca gcgacgucau cgacucccag gagcugagca aggugucccg cgaguuccac      780

agccacgagu uccacuccca cgaggacaug cugguggucg accccaagag caaggaggag      840

gacaagcacc ucaaguuccg gaucucccac gagcuggaca gcgccuccag cgaggugaac      900

uga                                                                    903


<210>  2977
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__EAX06009

<400>  2977
augcgcaucg ccgucaucug cuucugccuc cucggcauca ccugcgccau ccccgucaag       60

caggccgacu ccggcuccuc cgaggagaag cagcucuaca acaaguaccc cgacgccguc      120

gccaccuggc ucaaccccga ccccucccag aagcagaacc uccucgcccc ccagacccuc      180

cccuccaagu ccaacgaguc ccacgaccac auggacgaca uggacgacga ggacgacgac      240

gaccacgucg acucccagga cuccaucgac uccaacgacu ccgacgacgu cgacgacacc      300

gacgacuccc accaguccga cgagucccac cacuccgacg aguccgacga gcucgucacc      360

gacuucccca ccgaccuccc cgccaccgag gucuucaccc ccgucguccc caccgucgac      420

accuacgacg gccgcggcga cuccgucguc uacggccucc gcuccaaguc caagaaguuc      480

cgccgccccg acauccagua ccccgacgcc accgacgagg acaucaccuc ccacauggag      540

uccgaggagc ucaacggcgc cuacaaggcc auccccgucg cccaggaccu caacgccccc      600

uccgacuggg acucccgcgg caaggacucc uacgagaccu cccagcucga cgaccagucc      660

gccgagaccc acucccacaa gcagucccgc cucuacaagc gcaaggccaa cgacgagucc      720

aacgagcacu ccgacgucau cgacucccag gagcucucca aggucucccg cgaguuccac      780

ucccacgagu uccacuccca cgaggacaug cucgucgucg accccaaguc caaggaggag      840

gacaagcacc ucaaguuccg caucucccac gagcucgacu ccgccuccuc cgaggucaac      900

uga                                                                    903


<210>  2978
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__EAX06009

<400>  2978
augagaaucg ccgugauuug cuucugucug cucggcauaa ccugcgcuau ccccgucaag       60

caggcagaca gcggguccuc ugaggaaaaa caacuuuaca acaaguaucc ugaugccguu      120

gcgacauggc ugaauccaga cccgucacag aaacagaacu uguuagcucc ccagacucug      180

ccuaguaaga gcaaugaguc ccacgaucau auggacgaua uggacgauga agacgaugac      240

gaucacgugg acucucaaga uucgauugac ucaaacgaca gcgaugacgu agaugacacg      300

gaugacaguc aucaguccga ugagucucac cauagcgacg aauccgauga gcuagugacc      360

gacuuuccaa cagaucuccc cgccacugag gucuucaccc cugugguucc aacaguggac      420

accuacgacg gaagggguga uucagucgug uauggccugc ggaguaaaag caagaaguuu      480

cgccgacccg acauccagua cccugaugca acugacgaag auauuacauc ucacauggag      540

uccgaagaac uuaauggggc cuauaaagcu aucccaguag cacaggaccu gaacgccccg      600

ucagauuggg acagccgugg aaaggauagu uacgagaccu cucaauugga cgaucagucc      660

gcugaaacgc acagccauaa acagucgaga cucuauaaga ggaaagccaa ugacgagucu      720

aacgaacacu ccgauguuau agacucacag gagcugagua aggugagccg ggaguuccau      780

ucccacgagu uucacucuca ugaggacaug cuggucgugg aucccaagag caaagaagag      840

gacaagcacc ucaaauuccg caucucacau gaauuagaua gugcguccag cgaggugaau      900

uga                                                                    903


<210>  2979
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__EAX06009

<400>  2979
augagaaucg ccgugaucug cuucugccug cugggcauca ccugcgccau ccccgugaag       60

caggccgaca gcggcagcag cgaggagaag cagcuguaca acaaguaccc cgacgccgug      120

gccaccuggc ugaaccccga ccccagccag aagcagaacc ugcuggcccc ccagacccug      180

cccagcaaga gcaacgagag ccacgaccac auggacgaca uggacgacga ggacgacgac      240

gaccacgugg acagccagga cagcaucgac agcaacgaca gcgacgacgu ggacgacacc      300

gacgacagcc accagagcga cgagagccac cacagcgacg agagcgacga gcuggugacc      360

gacuucccca ccgaccugcc cgccaccgag guguucaccc ccguggugcc caccguggac      420

accuacgacg gcagaggcga cagcguggug uacggccuga gaagcaagag caagaaguuc      480

agaagacccg acauccagua ccccgacgcc accgacgagg acaucaccag ccacauggag      540

agcgaggagc ugaacggcgc cuacaaggcc auccccgugg cccaggaccu gaacgccccc      600

agcgacuggg acagcagagg caaggacagc uacgagacca gccagcugga cgaccagagc      660

gccgagaccc acagccacaa gcagagcaga cuguacaaga gaaaggccaa cgacgagagc      720

aacgagcaca gcgacgugau cgacagccag gagcugagca aggugagcag agaguuccac      780

agccacgagu uccacagcca cgaggacaug cugguggugg accccaagag caaggaggag      840

gacaagcacc ugaaguucag aaucagccac gagcuggaca gcgccagcag cgaggugaac      900

uga                                                                    903


<210>  2980
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__EAX06009

<400>  2980
augagaaucg ccgugauuug cuucugucug cucggcauua ccugcgcuau ccccgucaag       60

caggccgaca gcggguccuc ugaggaaaaa caacuguaca acaaguaucc ugaugcgguu      120

gcuacauggc uuaauccgga ccccagccag aaacagaacc ugcucgcccc ucagacgcug      180

cccuccaagu cuaaugagag ccacgaucau auggacgaua uggacgauga agacgaugac      240

gaucacgugg acucccaaga uucuaucgac agcaacgacu ccgaugacgu ggaugacacc      300

gaugacagcc aucagucuga ugagucccac cauagcgacg aaucugauga gcuugucaca      360

gacuuuccua ccgaucugcc cgccacagag guguucaccc cuguugugcc gacagucgac      420

accuacgacg gacggggcga uuccgugguu uaugggcucc gcagcaaauc uaagaaguuu      480

agacggcccg acauucagua cccugaugcu acggacgaag auaucaccuc ccacauggag      540

agcgaagaac ugaauggagc cuauaaagcu auccccgugg cccaggaccu gaacgcgccu      600

uccgauuggg acucucgcgg caaggauagc uacgagacau cccaacucga cgaucagagc      660

gccgaaaccc acucucauaa acaguccaga cuguauaagc ggaaagcuaa ugacgagagc      720

aacgaacacu cugaugucau ugacagccag gagcuuucca aggugucucg cgaguuccau      780

agccacgagu uucacuccca ugaggacaug cugguggucg aucccaagag caaagaagag      840

gacaagcacc ucaaauucag aaucucucau gaacuggauu ccgccagcuc ugagguuaau      900

uga                                                                    903


<210>  2981
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__A0A024RDJ0

<400>  2981

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Asn 
            20                  25                  30          


Ala Val Ser Ser Glu Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro 
        35                  40                  45              


Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu 
    50                  55                  60                  


Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp 
65                  70                  75                  80  


Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser 
                85                  90                  95      


His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp 
            100                 105                 110         


Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr 
        115                 120                 125             


Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser 
    130                 135                 140                 


Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu 
145                 150                 155                 160 


Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys 
                165                 170                 175     


Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
            180                 185                 190         


Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala 
        195                 200                 205             


Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn 
    210                 215                 220                 


Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser 
225                 230                 235                 240 


Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp 
                245                 250                 255     


Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys 
            260                 265                 270         


Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
        275                 280                 285         


<210>  2982
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__EAX06010

<400>  2982
augagaauug cagugauuug cuuuugccuc cuaggcauca ccugugccau accaguuaaa       60

caggcugauu cuggaaguuc ugaggaaaag cagaaugcug uguccucuga agaaaccaau      120

gacuuuaaac aagagacccu uccaaguaag uccaacgaaa gccaugacca cauggaugau      180

auggaugaug aagaugauga ugaccaugug gacagccagg acuccauuga cucgaacgac      240

ucugaugaug uagaugacac ugaugauucu caccagucug augagucuca ccauucugau      300

gaaucugaug aacuggucac ugauuuuccc acggaccugc cagcaaccga aguuuucacu      360

ccaguugucc ccacaguaga cacauaugau ggccgaggug auaguguggu uuauggacug      420

aggucaaaau cuaagaaguu ucgcagaccu gacauccagu acccugaugc uacagacgag      480

gacaucaccu cacacaugga aagcgaggag uugaauggug cauacaaggc cauccccguu      540

gcccaggacc ugaacgcgcc uucugauugg gacagccgug ggaaggacag uuaugaaacg      600

agucagcugg augaccagag ugcugaaacc cacagccaca agcaguccag auuauauaag      660

cggaaagcca augaugagag caaugagcau uccgauguga uugauaguca ggaacuuucc      720

aaagucagcc gugaauucca cagccaugaa uuucacagcc augaagauau gcugguugua      780

gaccccaaaa guaaggaaga agauaaacac cugaaauuuc guauuucuca ugaauuagau      840

agugcaucuu cugaggucaa uuaa                                             864


<210>  2983
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__EAX06010

<400>  2983
augcgcaucg ccgugaucug cuucugccug cucggcauca cgugcgccau ccccgucaag       60

caggcggaca gcggguccag cgaggagaag cagaacgccg uguccagcga ggagaccaac      120

gacuucaagc aggagacccu gccguccaag agcaacgagu cccacgacca cauggacgac      180

auggacgacg aggacgacga cgaccacgug gacagccagg acuccaucga cagcaacgac      240

uccgacgacg ucgacgacac cgacgacagc caccaguccg acgagagcca ccacuccgac      300

gagagcgacg agcuggugac cgacuucccc accgaccucc ccgccacgga gguguucacc      360

cccgucgugc cgaccgugga caccuacgac ggccgcgggg acuccgucgu guacggccug      420

cggagcaagu ccaagaaguu ccggcgcccc gacauccagu accccgacgc cacggacgag      480

gacaucacca gccacaugga gagcgaggag cugaacgggg ccuacaaggc gauccccgug      540

gcccaggacc ucaacgcccc guccgacugg gacagccggg gcaaggacuc cuacgagacc      600

agccagcugg acgaccaguc cgccgagacc cacagccaca agcagucccg ccuguacaag      660

cggaaggcga acgacgagag caacgagcac uccgacguca ucgacagcca ggagcucucc      720

aaggugagcc gcgaguucca cucccacgag uuccacagcc acgaggacau gcuggugguc      780

gaccccaagu ccaaggagga ggacaagcac cugaaguucc ggaucagcca cgagcucgac      840

uccgccagcu ccgaggugaa cuga                                             864


<210>  2984
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__EAX06010

<400>  2984
augcgcaucg ccgucaucug cuucugccuc cucggcauca ccugcgccau ccccgucaag       60

caggccgacu ccggcuccuc cgaggagaag cagaacgccg ucuccuccga ggagaccaac      120

gacuucaagc aggagacccu ccccuccaag uccaacgagu cccacgacca cauggacgac      180

auggacgacg aggacgacga cgaccacguc gacucccagg acuccaucga cuccaacgac      240

uccgacgacg ucgacgacac cgacgacucc caccaguccg acgaguccca ccacuccgac      300

gaguccgacg agcucgucac cgacuucccc accgaccucc ccgccaccga ggucuucacc      360

cccgucgucc ccaccgucga caccuacgac ggccgcggcg acuccgucgu cuacggccuc      420

cgcuccaagu ccaagaaguu ccgccgcccc gacauccagu accccgacgc caccgacgag      480

gacaucaccu cccacaugga guccgaggag cucaacggcg ccuacaaggc cauccccguc      540

gcccaggacc ucaacgcccc cuccgacugg gacucccgcg gcaaggacuc cuacgagacc      600

ucccagcucg acgaccaguc cgccgagacc cacucccaca agcagucccg ccucuacaag      660

cgcaaggcca acgacgaguc caacgagcac uccgacguca ucgacuccca ggagcucucc      720

aaggucuccc gcgaguucca cucccacgag uuccacuccc acgaggacau gcucgucguc      780

gaccccaagu ccaaggagga ggacaagcac cucaaguucc gcaucuccca cgagcucgac      840

uccgccuccu ccgaggucaa cuga                                             864


<210>  2985
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__EAX06010

<400>  2985
augagaaucg ccgugauuug cuucugucug cucggcauaa ccugcgcuau ccccgucaag       60

caggcagaca gcggguccuc ugaggaaaaa caaaacgccg uuucaaguga ggaaacaaau      120

gauuuuaagc aggagacucu uccuagcaaa uccaacgaau cucacgacca uauggaugac      180

auggaugacg aggaugacga ugaccacgug gauucgcagg acucaauuga uagcaaugac      240

agugacgaug uagacgauac ggacgauucc caucagucug acgagagcca ccauuccgau      300

gaaucagacg agcuggugac cgauuuccca acagacuugc cggcgacuga agucuuuacc      360

cccgugguuc cuacagugga uaccuacgac ggaaggggug acagugucgu guauggcuua      420

cggagcaagu cuaaaaaguu ccgccgacca gauauccaau accccgacgc uacugaugag      480

gacauuacau cccacaugga gucagaggaa cugaacgggg ccuauaaggc aaucccugua      540

gcccaggauc uaaaugcucc aagcgacugg gauagucgug gaaaagacuc uuacgaaacc      600

ucccagcucg augaccagag cgcagagacg cacucgcaua agcaaucuag acuguauaaa      660

aggaaggcca acgaugaauc caaugagcac ucagacguua uagauaguca ggagcuuagc      720

aaaguguccc gggaauuuca uucucacgag uuccacagcc augaagacau gcuggucgug      780

gaccccaagu caaaggagga agauaaacac uugaaguuuc gcaucaguca ugagcucgac      840

uccgcuagcu cugaggugaa cuga                                             864


<210>  2986
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__EAX06010

<400>  2986
augagaaucg ccgugaucug cuucugccug cugggcauca ccugcgccau ccccgugaag       60

caggccgaca gcggcagcag cgaggagaag cagaacgccg ugagcagcga ggagaccaac      120

gacuucaagc aggagacccu gcccagcaag agcaacgaga gccacgacca cauggacgac      180

auggacgacg aggacgacga cgaccacgug gacagccagg acagcaucga cagcaacgac      240

agcgacgacg uggacgacac cgacgacagc caccagagcg acgagagcca ccacagcgac      300

gagagcgacg agcuggugac cgacuucccc accgaccugc ccgccaccga gguguucacc      360

cccguggugc ccaccgugga caccuacgac ggcagaggcg acagcguggu guacggccug      420

agaagcaaga gcaagaaguu cagaagaccc gacauccagu accccgacgc caccgacgag      480

gacaucacca gccacaugga gagcgaggag cugaacggcg ccuacaaggc cauccccgug      540

gcccaggacc ugaacgcccc cagcgacugg gacagcagag gcaaggacag cuacgagacc      600

agccagcugg acgaccagag cgccgagacc cacagccaca agcagagcag acuguacaag      660

agaaaggcca acgacgagag caacgagcac agcgacguga ucgacagcca ggagcugagc      720

aaggugagca gagaguucca cagccacgag uuccacagcc acgaggacau gcugguggug      780

gaccccaaga gcaaggagga ggacaagcac cugaaguuca gaaucagcca cgagcuggac      840

agcgccagca gcgaggugaa cuga                                             864


<210>  2987
<211>  864
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__EAX06010

<400>  2987
augagaaucg ccgugauuug cuucugucug cucggcauua ccugcgcuau ccccgucaag       60

caggccgaca gcggguccuc ugaggaaaaa caaaacgcgg uuagcuccga ggaaacaaau      120

gauuuuaagc aggagacgcu gccuucuaaa agcaacgaau cccacgacca uauggaugac      180

auggaugacg aggaugacga ugaccacgug gauucucagg acagcaucga uuccaaugac      240

agcgacgaug uggacgauac cgacgauucu caucaguccg acgagagcca ccauucugau      300

gaauccgacg agcuugucac agauuucccg accgaccugc ccgcuacaga aguguuuacc      360

ccuguugugc ccacagucga uaccuacgac ggacggggcg acagcguggu uuaugggcuc      420

cgcucuaagu ccaaaaaguu cagacggccu gauauucaau accccgacgc cacggaugag      480

gacaucacca gccacaugga guccgaggaa cugaacggag ccuauaaggc uaucccugug      540

gcccaggauc uuaaugcucc gucugacugg gauagccgcg gcaaagacuc cuacgaaaca      600

agccagcugg augaccaguc ugccgagacc cacucccaua agcaaagcag acucuauaaa      660

cggaaggcga acgaugaauc uaaugagcac agcgacguca uugauuccca ggagcugucu      720

aaagugagcc gcgaauuuca uucccacgag uuccacagcc augaagacau gcuggugguc      780

gaccccaagu cuaaggagga agauaaacac cucaaguuua gaaucuccca ugagcuggac      840

agcgccucuu ccgagguuaa cuga                                             864


<210>  2988
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__B7Z351

<400>  2988

Met Gly Ile Val Pro Arg Ser Leu Asp Lys Lys Ala His Arg Val Gln 
1               5                   10                  15      


Phe Gln Leu Asn Arg Ile Lys Ala Lys Ile Glu Leu Pro Trp Gly Ser 
            20                  25                  30          


Leu Gln Leu Asp Cys Leu Met Lys Thr Leu Lys Glu Leu Tyr Asn Lys 
        35                  40                  45              


Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro Ser Gln Lys 
    50                  55                  60                  


Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu Thr Asn 
65                  70                  75                  80  


Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu Ser His Asp 
                85                  90                  95      


His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His Val Asp Ser 
            100                 105                 110         


Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp Asp Thr Asp 
        115                 120                 125             


Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu 
    130                 135                 140                 


Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr 
145                 150                 155                 160 


Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val 
                165                 170                 175     


Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile 
            180                 185                 190         


Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser 
        195                 200                 205             


Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu 
    210                 215                 220                 


Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr 
225                 230                 235                 240 


Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser 
                245                 250                 255     


Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp 
            260                 265                 270         


Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser 
        275                 280                 285             


His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser 
    290                 295                 300                 


Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp 
305                 310                 315                 320 


Ser Ala Ser Ser Glu Val Asn 
                325         


<210>  2989
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__BAH12087

<400>  2989
augggcauug uccccagaag cuuggacaaa aaggcacaca gaguucaauu ccaguugaac       60

agaauaaagg ccaaaauaga gcugccuugg gggucacugc aauuagacug cuugaugaag      120

acauuaaaag aacuuuacaa caaauaccca gaugcugugg ccacauggcu aaacccugac      180

ccaucucaga agcagaaucu ccuagcccca cagaaugcug uguccucuga agaaaccaau      240

gacuuuaaac aagagacccu uccaaguaag uccaacgaaa gccaugacca cauggaugau      300

auggaugaug aagaugauga ugaccaugug gacagccagg acuccauuga cucgaacgac      360

ucugaugaug uagaugacac ugaugauucu caccagucug augagucuca ccauucugau      420

gaaucugaug aacuggucac ugauuuuccc acggaccugc cagcaaccga aguuuucacu      480

ccaguugucc ccacaguaga cacauaugau ggccgaggug auaguguggu uuauggacug      540

aggucaaaau cuaagaaguu ucgcagaccu gacauccagu acccugaugc uacagacgag      600

gacaucaccu cacacaugga aagcgaggag uugaauggug cauacaaggc cauccccguu      660

gcccaggacc ugaacgcgcc uucugauugg gacagccgug ggaaggacag uuaugaaacg      720

agucagcugg augaccagag ugcugaaacc cacagccaca agcaguccag auuauauaag      780

cggaaagcca augaugagag caaugagcau uccgauguga uugauaguca ggaacuuucc      840

aaagucagcc gugaauucca cagccaugaa uuucacagcc augaagauau gcugguugua      900

gaccccaaaa guaaggaaga agauaaacac cugaaauuuc guauuucuca ugaauuagau      960

agugcaucuu cugaggucaa uuaa                                             984


<210>  2990
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__BAH12087

<400>  2990
augggcaucg ugccccgcag ccuggacaag aaggcccacc ggguccaguu ccagcucaac       60

cgcaucaagg ccaagaucga gcugccgugg gggucccugc agcucgacug ccugaugaag      120

acccugaagg agcucuacaa caaguacccc gacgcggugg ccaccuggcu gaaccccgac      180

cccagccaga agcagaaccu gcucgccccg cagaacgccg uguccagcga ggagacgaac      240

gacuucaagc aggagacccu gcccuccaag agcaacgagu cccacgacca cauggacgac      300

auggacgacg aggacgacga cgaccacguc gacagccagg acuccaucga cagcaacgac      360

uccgacgacg uggacgacac cgacgacagc caccaguccg acgagagcca ccacuccgac      420

gagagcgacg agcuggugac cgacuucccc acggaccucc ccgccaccga ggucuucacc      480

ccgguggugc ccaccgucga cacguacgac ggccgcgggg acuccguggu guacggccug      540

cggagcaagu ccaagaaguu ccggcgcccc gacauccagu accccgacgc gaccgacgag      600

gacaucacca gccacaugga gagcgaggag cugaacgggg ccuacaaggc caucccgguc      660

gcccaggacc ucaacgcgcc cuccgacugg gacagccggg gcaaggacuc cuacgagacc      720

agccagcugg acgaccaguc cgccgagacg cacagccaca agcagucccg ccuguacaag      780

cggaaggcca acgacgagag caacgagcac uccgacguga ucgacagcca ggagcucucc      840

aaggugagcc gcgaguucca cucccacgag uuccacagcc acgaggacau gcuggucgug      900

gaccccaagu ccaaggagga ggacaagcac cugaaguucc ggaucagcca cgagcucgac      960

uccgccagcu ccgaggugaa cuga                                             984


<210>  2991
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__BAH12087

<400>  2991
augggcaucg ucccccgcuc ccucgacaag aaggcccacc gcguccaguu ccagcucaac       60

cgcaucaagg ccaagaucga gcuccccugg ggcucccucc agcucgacug ccucaugaag      120

acccucaagg agcucuacaa caaguacccc gacgccgucg ccaccuggcu caaccccgac      180

cccucccaga agcagaaccu ccucgccccc cagaacgccg ucuccuccga ggagaccaac      240

gacuucaagc aggagacccu ccccuccaag uccaacgagu cccacgacca cauggacgac      300

auggacgacg aggacgacga cgaccacguc gacucccagg acuccaucga cuccaacgac      360

uccgacgacg ucgacgacac cgacgacucc caccaguccg acgaguccca ccacuccgac      420

gaguccgacg agcucgucac cgacuucccc accgaccucc ccgccaccga ggucuucacc      480

cccgucgucc ccaccgucga caccuacgac ggccgcggcg acuccgucgu cuacggccuc      540

cgcuccaagu ccaagaaguu ccgccgcccc gacauccagu accccgacgc caccgacgag      600

gacaucaccu cccacaugga guccgaggag cucaacggcg ccuacaaggc cauccccguc      660

gcccaggacc ucaacgcccc cuccgacugg gacucccgcg gcaaggacuc cuacgagacc      720

ucccagcucg acgaccaguc cgccgagacc cacucccaca agcagucccg ccucuacaag      780

cgcaaggcca acgacgaguc caacgagcac uccgacguca ucgacuccca ggagcucucc      840

aaggucuccc gcgaguucca cucccacgag uuccacuccc acgaggacau gcucgucguc      900

gaccccaagu ccaaggagga ggacaagcac cucaaguucc gcaucuccca cgagcucgac      960

uccgccuccu ccgaggucaa cuga                                             984


<210>  2992
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__BAH12087

<400>  2992
augggcaucg ugcccagaag ccuggacaag aaagcccaca ggguccaguu ccaacucaac       60

cggauuaagg cuaaaauaga gcuuccuugg gggucccugc aguuggauug cuuaaugaag      120

acccugaaag aacuauacaa uaaguaucca gacgcaguug ccacauggcu caacccggau      180

cccucucaga agcagaaucu gcuugcgccu caaaacgcug ugucaaguga ggaaacuaau      240

gacuuuaaac aggagacgcu gccaagcaag uccaacgaau cucaugauca cauggacgau      300

auggacgaug aggacgauga cgaucaugua gacucgcagg acucaaucga uagcaaugac      360

agugaugacg uggaugacac cgaugacucc caccagucug augagagcca ucacuccgac      420

gaaucagaug aguuggucac agacuucccc acugaccucc cugccaccga aguguuuaca      480

ccaguugugc ccaccgucga uacuuacgac ggacgcggug auaguguggu auauggccug      540

cgaagcaaau cuaagaaauu ccguagaccu gacauucaau acccagaugc aacagacgag      600

gauaucaccu cccacaugga gucagaggaa cugaacgggg ccuauaaggc uauuccgguu      660

gcacaggacc ucaaugcccc cagcgauugg gacaguaggg gaaaggauuc uuacgaaacg      720

ucccaguuag acgaucagag cgcugagacu cauucgcaca aacaaucucg gcuguauaag      780

cgcaaagcca acgacgaauc caaugagcau ucagacguga ucgauaguca ggagcuuagc      840

aaggucucca gagaauuuca cucucacgag uuccauagcc acgaagacau guugguggug      900

gauccuaaau caaaggagga agacaaacau cugaaguuua ggauaaguca cgagcuagau      960

uccgcgagcu cugaggucaa cuga                                             984


<210>  2993
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__BAH12087

<400>  2993
augggcaucg ugcccagaag ccuggacaag aaggcccaca gagugcaguu ccagcugaac       60

agaaucaagg ccaagaucga gcugcccugg ggcagccugc agcuggacug ccugaugaag      120

acccugaagg agcuguacaa caaguacccc gacgccgugg ccaccuggcu gaaccccgac      180

cccagccaga agcagaaccu gcuggccccc cagaacgccg ugagcagcga ggagaccaac      240

gacuucaagc aggagacccu gcccagcaag agcaacgaga gccacgacca cauggacgac      300

auggacgacg aggacgacga cgaccacgug gacagccagg acagcaucga cagcaacgac      360

agcgacgacg uggacgacac cgacgacagc caccagagcg acgagagcca ccacagcgac      420

gagagcgacg agcuggugac cgacuucccc accgaccugc ccgccaccga gguguucacc      480

cccguggugc ccaccgugga caccuacgac ggcagaggcg acagcguggu guacggccug      540

agaagcaaga gcaagaaguu cagaagaccc gacauccagu accccgacgc caccgacgag      600

gacaucacca gccacaugga gagcgaggag cugaacggcg ccuacaaggc cauccccgug      660

gcccaggacc ugaacgcccc cagcgacugg gacagcagag gcaaggacag cuacgagacc      720

agccagcugg acgaccagag cgccgagacc cacagccaca agcagagcag acuguacaag      780

agaaaggcca acgacgagag caacgagcac agcgacguga ucgacagcca ggagcugagc      840

aaggugagca gagaguucca cagccacgag uuccacagcc acgaggacau gcugguggug      900

gaccccaaga gcaaggagga ggacaagcac cugaaguuca gaaucagcca cgagcuggac      960

agcgccagca gcgaggugaa cuga                                             984


<210>  2994
<211>  984
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__BAH12087

<400>  2994
augggcaucg ugcccagaag ccuggacaag aaagcccacc ggguccaguu ccaacucaac       60

cgcauuaagg cuaaaaucga gcugccuugg gggucccuuc agcuggauug ccucaugaag      120

acccugaaag aacuuuacaa uaaguauccg gacgccguug cgacauggcu gaaccccgau      180

ccuucucaga agcagaaucu ccuggcuccc caaaacgccg ugagcuccga ggaaacgaau      240

gacuuuaaac aggagacccu gccuucuaag agcaacgaau cccaugauca cauggacgau      300

auggacgaug aggacgauga cgaucaugug gacucucagg acagcauuga uuccaaugac      360

agcgaugacg ucgaugacac agaugacucu caccaguccg augagagcca ucacucugac      420

gaauccgaug agcucgugac cgacuucccc acagaccugc cugccaccga aguuuuuaca      480

ccgguggucc ccaccgugga uacguacgac ggaagaggcg auagcguugu guaugggcuu      540

cggucuaaau ccaagaaauu ccgcagaccu gacauccaau accccgaugc uaccgacgag      600

gauauuacaa gccacaugga guccgaggaa cugaacggag ccuauaaggc uaucccuguc      660

gcccaggacc ucaaugcgcc cucugauugg gacagccggg gcaaggauuc cuacgaaacc      720

agccagcugg acgaucaguc ugccgagaca cauucccaca aacaaagccg ccuuuauaag      780

agaaaagcua acgacgaauc uaaugagcau agcgacguga ucgauuccca ggagcugucu      840

aaggugagcc gggaauuuca cucccacgag uuccauagcc acgaagacau gcucgucguu      900

gauccgaaau cuaaggagga agacaaacau cugaaguuuc gcauuuccca cgagcuggau      960

agcgccucuu ccgaggugaa cuga                                             984


<210>  2995
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__F2YQ21

<400>  2995

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Ser His 
                85                  90                  95      


Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val Thr 
            100                 105                 110         


Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val 
        115                 120                 125             


Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
    130                 135                 140                 


Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro 
145                 150                 155                 160 


Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu 
                165                 170                 175     


Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro 
            180                 185                 190         


Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu 
        195                 200                 205             


Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr 
    210                 215                 220                 


Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp 
225                 230                 235                 240 


Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser His Glu Phe 
                245                 250                 255     


His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu 
            260                 265                 270         


Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser 
        275                 280                 285             


Ser Glu Val Asn 
    290         


<210>  2996
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__AEA49030

<400>  2996
augagaauug cagugauuug cuuuugccuc cuaggcauca ccugugccau accaguuaaa       60

caggcugauu cuggaaguuc ugaggaaaag cagcuuuaca acaaauaccc agaugcugug      120

gccacauggc uaaacccuga cccaucucag aagcagaauc uccuagcccc acagaaugcu      180

guguccucug aagaaaccaa ugacuuuaaa caagagaccc uuccaaguaa guccaacgaa      240

agccaugacc acauggauga uauggaugau gaagaugaug auucucacca gucugaugag      300

ucucaccauu cugaugaauc ugaugaacug gucacugauu uucccacgga ccugccagca      360

accgaaguuu ucacuccagu uguccccaca guagacacau augauggccg aggugauagu      420

gugguuuaug gacugagguc aaaaucuaag aaguuucgca gaccugacau ccaguacccu      480

gaugcuacag acgaggacau caccucacac auggaaagcg aggaguugaa uggugcauac      540

aaggccaucc ccguugccca ggaccugaac gcgccuucug auugggacag ccgugggaag      600

gacaguuaug aaacgaguca gcuggaugac cagagugcug aaacccacag ccacaagcag      660

uccagauuau auaagcggaa agcuaaugau gagagcaaug agcauuccga ugugauugau      720

agucaggaac uuuccaaagu cagccgugaa uuccacagcc augaauuuca cagccaugaa      780

gauaugcugg uuguagaccc caaaaguaag gaagaagaua aacaccugaa auuucguauu      840

ucucaugaau uagauagugc aucuucugag gucaauuaa                             879


<210>  2997
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__AEA49030

<400>  2997
augcgcaucg ccgugaucug cuucugccug cucggcauca cgugcgccau ccccgucaag       60

caggcggaca gcggguccag cgaggagaag cagcuguaca acaaguaccc ggacgccgug      120

gccaccuggc ugaaccccga ccccucccag aagcagaacc uccuggcgcc ccagaacgcc      180

gugagcuccg aggagaccaa cgacuucaag caggagaccc ugccgagcaa guccaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acucccacca gagcgacgag      300

ucccaccaca gcgacgaguc cgacgagcuc gucaccgacu uccccaccga ccugcccgcc      360

acggaggugu ucacccccgu ggucccgacc guggacaccu acgacggccg cggggacagc      420

guggucuacg gccugcgguc caagagcaag aaguuccggc gccccgacau ccaguacccc      480

gacgccacgg acgaggacau caccucccac auggagagcg aggagcucaa cggggccuac      540

aaggccaucc ccguggcgca ggaccugaac gccccguccg acugggacag ccggggcaag      600

gacagcuacg agaccuccca gcuggacgac cagagcgccg agacccacuc ccacaagcag      660

agccgccucu acaagcggaa ggccaacgac gaguccaacg agcacagcga cgugaucgac      720

ucccaggagc ugagcaaggu cucccgcgag uuccacagcc acgaguucca cucccacgag      780

gacaugcugg ugguggaccc caagagcaag gaggaggaca agcaccucaa guuccggauc      840

ucccacgagc uggacagcgc cuccagcgag gucaacuga                             879


<210>  2998
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__AEA49030

<400>  2998
augcgcaucg ccgucaucug cuucugccuc cucggcauca ccugcgccau ccccgucaag       60

caggccgacu ccggcuccuc cgaggagaag cagcucuaca acaaguaccc cgacgccguc      120

gccaccuggc ucaaccccga ccccucccag aagcagaacc uccucgcccc ccagaacgcc      180

gucuccuccg aggagaccaa cgacuucaag caggagaccc uccccuccaa guccaacgag      240

ucccacgacc acauggacga cauggacgac gaggacgacg acucccacca guccgacgag      300

ucccaccacu ccgacgaguc cgacgagcuc gucaccgacu uccccaccga ccuccccgcc      360

accgaggucu ucacccccgu cguccccacc gucgacaccu acgacggccg cggcgacucc      420

gucgucuacg gccuccgcuc caaguccaag aaguuccgcc gccccgacau ccaguacccc      480

gacgccaccg acgaggacau caccucccac auggaguccg aggagcucaa cggcgccuac      540

aaggccaucc ccgucgccca ggaccucaac gcccccuccg acugggacuc ccgcggcaag      600

gacuccuacg agaccuccca gcucgacgac caguccgccg agacccacuc ccacaagcag      660

ucccgccucu acaagcgcaa ggccaacgac gaguccaacg agcacuccga cgucaucgac      720

ucccaggagc ucuccaaggu cucccgcgag uuccacuccc acgaguucca cucccacgag      780

gacaugcucg ucgucgaccc caaguccaag gaggaggaca agcaccucaa guuccgcauc      840

ucccacgagc ucgacuccgc cuccuccgag gucaacuga                             879


<210>  2999
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__AEA49030

<400>  2999
augagaaucg ccgugauuug cuucugucug cucggcauaa ccugcgcuau ccccgucaag       60

caggcagaca gcggguccuc ugaggaaaaa caacuuuaca acaaguaucc ugaugccguu      120

gcgacauggc ugaauccaga cccgucacag aaacagaacu uguuagcucc ccagaaugcc      180

gugaguagcg aggaaacuaa cgauuuuaag caagagacgc ugccuuccaa aucuaaugaa      240

ucgcacgacc auauggauga cauggaugac gaggaugacg auucacacca gagcgacgag      300

agucaucacu ccgaugaauc ugacgagcua guaaccgacu ucccaacaga ucuccccgca      360

acugaagugu uuaccccugu cgugccaaca guugacaccu acgauggaag gggugacagc      420

guggucuaug gccugcgguc caagucaaag aaauuccgcc gacccgauau ucaguacccu      480

gacgccacug augaggacau cacaagucau auggagagcg aggaacuuaa cggggcuuau      540

aaggcaauuc caguggccca ggaucugaau gcuccgucug acugggauuc ccguggaaaa      600

gacucauacg aaaccagcca auuggacgau cagagugccg agacgcacuc ucacaagcag      660

uccagacucu auaaaaggaa ggcgaacgac gaaagcaaug agcauucgga uguaaucgac      720

ucucaggagc uguccaaggu uucacgggaa uuucacaguc augaguucca cagccacgaa      780

gauaugcugg uggucgaccc caaauccaag gaggaagaua aacaucucaa guuucgcaua      840

ucucacgagu uagacagcgc aucaagugag gugaacuga                             879


<210>  3000
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__AEA49030

<400>  3000
augagaaucg ccgugaucug cuucugccug cugggcauca ccugcgccau ccccgugaag       60

caggccgaca gcggcagcag cgaggagaag cagcuguaca acaaguaccc cgacgccgug      120

gccaccuggc ugaaccccga ccccagccag aagcagaacc ugcuggcccc ccagaacgcc      180

gugagcagcg aggagaccaa cgacuucaag caggagaccc ugcccagcaa gagcaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acagccacca gagcgacgag      300

agccaccaca gcgacgagag cgacgagcug gugaccgacu uccccaccga ccugcccgcc      360

accgaggugu ucacccccgu ggugcccacc guggacaccu acgacggcag aggcgacagc      420

gugguguacg gccugagaag caagagcaag aaguucagaa gacccgacau ccaguacccc      480

gacgccaccg acgaggacau caccagccac auggagagcg aggagcugaa cggcgccuac      540

aaggccaucc ccguggccca ggaccugaac gcccccagcg acugggacag cagaggcaag      600

gacagcuacg agaccagcca gcuggacgac cagagcgccg agacccacag ccacaagcag      660

agcagacugu acaagagaaa ggccaacgac gagagcaacg agcacagcga cgugaucgac      720

agccaggagc ugagcaaggu gagcagagag uuccacagcc acgaguucca cagccacgag      780

gacaugcugg ugguggaccc caagagcaag gaggaggaca agcaccugaa guucagaauc      840

agccacgagc uggacagcgc cagcagcgag gugaacuga                             879


<210>  3001
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__AEA49030

<400>  3001
augagaaucg ccgugauuug cuucugucug cucggcauua ccugcgcuau ccccgucaag       60

caggccgaca gcggguccuc ugaggaaaaa caacuguaca acaaguaucc ugaugcgguu      120

gcuacauggc uuaauccgga ccccagccag aaacagaacc ugcucgcccc ucagaaugcc      180

guguccucug aggaaacgaa cgauuuuaag caagagaccc ugcccagcaa auccaaugaa      240

ucucacgacc auauggauga cauggaugac gaggaugacg auagccacca guccgacgag      300

agccaucacu cugaugaauc cgacgagcuu gugacagacu ucccuaccga ucugcccgcu      360

acagaagucu uuaccccugu gguuccgaca guggacaccu acgauggacg gggcgacagc      420

gucguguaug ggcuccgcuc uaaguccaag aaauucagac ggcccgauau ccaguacccu      480

gacgccacgg augaggacau uaccagccau auggagucug aggaacugaa cggagcuuau      540

aaggccaucc ccguugcgca ggaucugaau gccccuuccg acugggauag ccgcggcaaa      600

gacuccuacg aaacaucuca acucgacgau cagagcgcug agacccacuc ccacaagcag      660

agcagacugu auaaacggaa ggccaacgac gaaucuaaug agcauuccga ugugaucgac      720

agccaggagc uuucuaaggu cagccgcgaa uuucacuccc augaguucca cucucacgaa      780

gauaugcugg ugguggaccc caaaagcaag gaggaagaua aacaucucaa guuuagaauu      840

ucccacgagc uggacagcgc uucuuccgag gucaacuga                             879


<210>  3002
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__P10451

<400>  3002

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  3003
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  osteopontin__Homo_sapiens__AAA86886

<400>  3003
augagaauug cagugauuug cuuuugccuc cuaggcauca ccugugccau accaguuaaa       60

caggcugauu cuggaaguuc ugaggaaaag cagcuuuaca acaaauaccc agaugcugug      120

gccacauggc uaaacccuga cccaucucag aagcagaauc uccuagcccc acagaaugcu      180

guguccucug aagaaaccaa ugacuuuaaa caagagaccc uuccaaguaa guccaacgaa      240

agccaugacc acauggauga uauggaugau gaagaugaug augaccaugu ggacagccag      300

gacuccauug acucgaacga cucugaugau guagaugaca cugaugauuc ucaccagucu      360

gaugagucuc accauucuga ugaaucugau gaacugguca cugauuuucc cacggaccug      420

ccagcaaccg aaguuuucac uccaguuguc cccacaguag acacauauga uggccgaggu      480

gauagugugg uuuauggacu gaggucaaaa ucuaagaagu uucgcagacc ugacauccag      540

uacccugaug cuacagacga ggacaucacc ucacacaugg aaagcgagga guugaauggu      600

gcauacaagg ccauccccgu ugcccaggac cugaacgcgc cuucugauug ggacagccgu      660

gggaaggaca guuaugaaac gagucagcug gaugaccaga gugcugaaac ccacagccac      720

aagcagucca gauuauauaa gcggaaagcc aaugaugaga gcaaugagca uuccgaugug      780

auugauaguc aggaacuuuc caaagucagc cgugaauucc acagccauga auuucacagc      840

caugaagaua ugcugguugu agaccccaaa aguaaggaag aagauaaaca ccugaaauuu      900

cguauuucuc augaauuaga uagugcaucu ucugagguca auuaa                      945


<210>  3004
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       osteopontin__Homo_sapiens__AAA86886

<400>  3004
augcgcaucg ccgugaucug cuucugccug cucggcauca cgugcgccau ccccgucaag       60

caggcggaca gcggguccag cgaggagaag cagcuguaca acaaguaccc ggacgccgug      120

gccaccuggc ugaaccccga ccccucccag aagcagaacc uccuggcgcc ccagaacgcc      180

gugagcuccg aggagaccaa cgacuucaag caggagaccc ugccgagcaa guccaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu cgacucccag      300

gacagcaucg acuccaacga cagcgacgac guggacgaca ccgacgacuc ccaccagagc      360

gacgaguccc accacagcga cgaguccgac gagcucguga ccgacuuccc cacggaccug      420

cccgccaccg aggucuucac ccccguggug ccgaccgucg acacguacga cggccgcggg      480

gacagcgugg uguacggccu gcgguccaag agcaagaagu uccggcgccc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc agccacaugg aguccgagga gcucaacggg      600

gccuacaagg ccauccccgu cgcgcaggac cugaacgccc cgagcgacug ggacucccgg      660

ggcaaggaca gcuacgagac cucccagcug gacgaccaga gcgccgagac gcacucccac      720

aagcagagcc gccucuacaa gcggaaggcc aacgacgagu ccaacgagca cagcgacgug      780

aucgacuccc aggagcugag caaggugucc cgcgaguucc acagccacga guuccacucc      840

cacgaggaca ugcuggucgu ggaccccaag agcaaggagg aggacaagca ccucaaguuc      900

cggaucuccc acgagcugga cagcgccucc agcgagguga acuga                      945


<210>  3005
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       osteopontin__Homo_sapiens__AAA86886

<400>  3005
augcgcaucg ccgucaucug cuucugccuc cucggcauca ccugcgccau ccccgucaag       60

caggccgacu ccggcuccuc cgaggagaag cagcucuaca acaaguaccc cgacgccguc      120

gccaccuggc ucaaccccga ccccucccag aagcagaacc uccucgcccc ccagaacgcc      180

gucuccuccg aggagaccaa cgacuucaag caggagaccc uccccuccaa guccaacgag      240

ucccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu cgacucccag      300

gacuccaucg acuccaacga cuccgacgac gucgacgaca ccgacgacuc ccaccagucc      360

gacgaguccc accacuccga cgaguccgac gagcucguca ccgacuuccc caccgaccuc      420

cccgccaccg aggucuucac ccccgucguc cccaccgucg acaccuacga cggccgcggc      480

gacuccgucg ucuacggccu ccgcuccaag uccaagaagu uccgccgccc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc ucccacaugg aguccgagga gcucaacggc      600

gccuacaagg ccauccccgu cgcccaggac cucaacgccc ccuccgacug ggacucccgc      660

ggcaaggacu ccuacgagac cucccagcuc gacgaccagu ccgccgagac ccacucccac      720

aagcaguccc gccucuacaa gcgcaaggcc aacgacgagu ccaacgagca cuccgacguc      780

aucgacuccc aggagcucuc caaggucucc cgcgaguucc acucccacga guuccacucc      840

cacgaggaca ugcucgucgu cgaccccaag uccaaggagg aggacaagca ccucaaguuc      900

cgcaucuccc acgagcucga cuccgccucc uccgagguca acuga                      945


<210>  3006
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       osteopontin__Homo_sapiens__AAA86886

<400>  3006
augagaaucg ccgugauuug cuucugucug cucggcauaa ccugcgcuau ccccgucaag       60

caggcagaca gcggguccuc ugaggaaaaa caacuuuaca acaaguaucc ugaugccguu      120

gcgacauggc ugaauccaga cccgucacag aaacagaacu uguuagcucc ccagaaugcc      180

gugaguagcg aggaaacuaa cgauuuuaag caagagacgc ugccuuccaa aucuaaugaa      240

ucgcacgacc auauggauga cauggaugac gaggaugacg augaccacgu agauucacag      300

gacagcauug acaguaacga uuccgacgau guggacgaua ccgacgauuc ucaucagagc      360

gacgaguccc accauucaga ugaaagugac gagcuaguca cagauuuccc aacugaccuc      420

cccgcaaccg aaguguuuac accuguugug ccaaccgucg acacuuacga uggaaggggu      480

gacagcgugg uauauggccu gcggucuaag uccaagaaau uccgccgacc cgauauccag      540

uacccugacg ccacagauga ggacauuacc ucacacaugg agagcgagga acuuaauggg      600

gcuuauaagg caaucccagu ugcccaagau cugaacgcuc cgagugacug ggauucucgu      660

ggaaaagacu ccuacgaaac gagccaguug gaugaccagu cggccgagac ucacucucau      720

aagcagucca gacucuauaa aaggaaggcg aaugaugaau caaacgagca cagugacgug      780

auagacagcc aagagcuguc caaggucucu cgggaauuuc auagccacga guuccacuca      840

caugaagaua ugcugguggu ggaccccaaa aguaaggagg aagauaaaca ccucaaguuu      900

cgcaucuccc augaguuaga cagcgcaucu ucagagguca auuga                      945


<210>  3007
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       osteopontin__Homo_sapiens__AAA86886

<400>  3007
augagaaucg ccgugaucug cuucugccug cugggcauca ccugcgccau ccccgugaag       60

caggccgaca gcggcagcag cgaggagaag cagcuguaca acaaguaccc cgacgccgug      120

gccaccuggc ugaaccccga ccccagccag aagcagaacc ugcuggcccc ccagaacgcc      180

gugagcagcg aggagaccaa cgacuucaag caggagaccc ugcccagcaa gagcaacgag      240

agccacgacc acauggacga cauggacgac gaggacgacg acgaccacgu ggacagccag      300

gacagcaucg acagcaacga cagcgacgac guggacgaca ccgacgacag ccaccagagc      360

gacgagagcc accacagcga cgagagcgac gagcugguga ccgacuuccc caccgaccug      420

cccgccaccg agguguucac ccccguggug cccaccgugg acaccuacga cggcagaggc      480

gacagcgugg uguacggccu gagaagcaag agcaagaagu ucagaagacc cgacauccag      540

uaccccgacg ccaccgacga ggacaucacc agccacaugg agagcgagga gcugaacggc      600

gccuacaagg ccauccccgu ggcccaggac cugaacgccc ccagcgacug ggacagcaga      660

ggcaaggaca gcuacgagac cagccagcug gacgaccaga gcgccgagac ccacagccac      720

aagcagagca gacuguacaa gagaaaggcc aacgacgaga gcaacgagca cagcgacgug      780

aucgacagcc aggagcugag caaggugagc agagaguucc acagccacga guuccacagc      840

cacgaggaca ugcugguggu ggaccccaag agcaaggagg aggacaagca ccugaaguuc      900

agaaucagcc acgagcugga cagcgccagc agcgagguga acuga                      945


<210>  3008
<211>  945
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       osteopontin__Homo_sapiens__AAA86886

<400>  3008
augagaaucg ccgugauuug cuucugucug cucggcauua ccugcgcuau ccccgucaag       60

caggccgaca gcggguccuc ugaggaaaaa caacuguaca acaaguaucc ugaugcgguu      120

gcuacauggc uuaauccgga ccccagccag aaacagaacc ugcucgcccc ucagaaugcc      180

guguccucug aggaaacgaa cgauuuuaag caagagaccc ugcccagcaa auccaaugaa      240

ucucacgacc auauggauga cauggaugac gaggaugacg augaccacgu ggauagccag      300

gacuccaucg acagcaacga uucugacgau gucgacgaua cagacgauuc ccaucagagc      360

gacgagucuc accauuccga ugaaagcgac gagcuuguga ccgauuuccc uacagaccug      420

cccgcuaccg aaguuuuuac accugugguc ccgaccgugg acacguacga uggacggggc      480

gacucuguug uguaugggcu ccgcuccaag agcaagaaau ucagacggcc cgauauucag      540

uacccugacg ccaccgauga ggacaucaca ucccacaugg agucugagga acugaaugga      600

gcuuauaagg ccauccccgu cgcgcaagau cugaacgccc cuagcgacug ggauucccgc      660

ggcaaagaca gcuacgaaac cucucagcuc gaugaccagu ccgcugagac acacagccau      720

aagcagucua gacuguauaa acggaaggcc aaugaugaaa gcaacgagca cuccgacgug      780

auugacucuc aagagcuuag caaggugucc cgcgaauuuc auagccacga guuccacucu      840

caugaagaua ugcuggucgu ugaccccaaa uccaaggagg aagauaaaca ccucaaguuu      900

agaaucagcc augagcugga cucugcuucc agcgagguga auuga                      945


<210>  3009
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  p53__Homo_sapiens__P04637

<400>  3009

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  3010
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  p53__Homo_sapiens__AAA59988

<400>  3010
auggaggagc cgcagucaga uccuagcguc gagcccccuc ugagucagga aacauuuuca       60

gaccuaugga aacuacuucc ugaaaacaac guucuguccc ccuugccguc ccaagcaaug      120

gaugauuuga ugcugucccc ggacgauauu gaacaauggu ucacugaaga cccaggucca      180

gaugaagcuc ccagaaugcc agaggcugcu ccccccgugg ccccugcacc agcagcuccu      240

acaccggcgg ccccugcacc agcccccucc uggccccugu caucuucugu cccuucccag      300

aaaaccuacc agggcagcua cgguuuccgu cugggcuucu ugcauucugg gacagccaag      360

ucugugacuu gcacguacuc cccugcccuc aacaagaugu uuugccaacu ggccaagacc      420

ugcccugugc agcugugggu ugauuccaca cccccgcccg gcacccgcgu ccgcgccaug      480

gccaucuaca agcagucaca gcacaugacg gagguuguga ggcgcugccc ccaccaugag      540

cgcugcucag auagcgaugg ucuggccccu ccucagcauc uuauccgagu ggaaggaaau      600

uugcgugugg aguauuugga ugacagaaac acuuuucgac auaguguggu ggugcccuau      660

gagccgccug agguuggcuc ugacuguacc accauccacu acaacuacau guguaacagu      720

uccugcaugg gcggcaugaa ccggaggccc auccucacca ucaucacacu ggaagacucc      780

agugguaauc uacugggacg gaacagcuuu gaggugcgug uuugugccug uccugggaga      840

gaccggcgca cagaggaaga gaaucuccgc aagaaagggg agccucacca cgagcugccc      900

ccagggagca cuaagcgagc acugcccaac aacaccagcu ccucucccca gccaaagaag      960

aaaccacugg auggagaaua uuucacccuu cagauccgug ggcgugagcg cuucgagaug     1020

uuccgagagc ugaaugaggc cuuggaacuc aaggaugccc aggcugggaa ggagccaggg     1080

gggagcaggg cucacuccag ccaccugaag uccaaaaagg gucagucuac cucccgccau     1140

aaaaaacuca uguucaagac agaagggccu gacucagacu ga                        1182


<210>  3011
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       p53__Homo_sapiens__AAA59988

<400>  3011
auggaggagc cccagagcga cccguccgug gagccgcccc ugagccagga gaccuucucc       60

gaccucugga agcugcugcc cgagaacaac guccucagcc cccugcccuc ccaggccaug      120

gacgaccuga ugcucagccc cgacgacauc gagcaguggu ucaccgagga ccccggcccg      180

gacgaggcgc cccgcaugcc cgaggccgcg cccccggugg cccccgcccc cgccgccccc      240

acgccggccg cccccgcccc cgcgcccucc uggccgcuga gcuccagcgu gcccucccag      300

aagaccuacc aggggagcua cggcuuccgg cugggguucc uccacuccgg caccgccaag      360

agcgugaccu gcacguacuc ccccgcccug aacaagaugu ucugccagcu ggccaagacc      420

ugccccgucc agcucugggu ggacagcacc ccgccgcccg ggacccgcgu ccgggccaug      480

gcgaucuaca agcaguccca gcacaugacg gagguggugc gccggugccc ccaccacgag      540

cgcugcagcg acuccgacgg ccuggccccg ccccagcacc ugauccgggu cgagggcaac      600

cuccgcgugg aguaccugga cgaccggaac accuuccgcc acagcguggu cgugcccuac      660

gagccgcccg agguggggag cgacugcacc accauccacu acaacuacau gugcaacucc      720

agcugcaugg gcgggaugaa ccggcgcccc auccugacga ucaucacccu cgaggacucc      780

agcggcaacc ugcuggggcg gaacuccuuc gagguccgcg ugugcgccug ccccggccgg      840

gaccgccgga ccgaggagga gaaccuccgc aagaagggcg agccccacca cgagcugccg      900

cccgggagca ccaagcgggc ccugcccaac aacacgucca gcagccccca gcccaagaag      960

aagccccucg acggcgagua cuucacccug cagauccgcg ggcgggagcg cuucgagaug     1020

uuccgcgagc ugaacgaggc ccucgagcug aaggacgcgc aggccggcaa ggagcccggc     1080

gggucccggg cccacuccag ccaccugaag uccaagaagg gccagagcac cucccgccac     1140

aagaagcuca uguucaagac cgaggggccg gacagcgacu ga                        1182


<210>  3012
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       p53__Homo_sapiens__AAA59988

<400>  3012
auggaggagc cccaguccga ccccuccguc gagccccccc ucucccagga gaccuucucc       60

gaccucugga agcuccuccc cgagaacaac guccucuccc cccuccccuc ccaggccaug      120

gacgaccuca ugcucucccc cgacgacauc gagcaguggu ucaccgagga ccccggcccc      180

gacgaggccc cccgcaugcc cgaggccgcc ccccccgucg cccccgcccc cgccgccccc      240

acccccgccg cccccgcccc cgcccccucc uggccccucu ccuccuccgu ccccucccag      300

aagaccuacc agggcuccua cggcuuccgc cucggcuucc uccacuccgg caccgccaag      360

uccgucaccu gcaccuacuc ccccgcccuc aacaagaugu ucugccagcu cgccaagacc      420

ugccccgucc agcucugggu cgacuccacc cccccccccg gcacccgcgu ccgcgccaug      480

gccaucuaca agcaguccca gcacaugacc gaggucgucc gccgcugccc ccaccacgag      540

cgcugcuccg acuccgacgg ccucgccccc ccccagcacc ucauccgcgu cgagggcaac      600

cuccgcgucg aguaccucga cgaccgcaac accuuccgcc acuccgucgu cguccccuac      660

gagccccccg aggucggcuc cgacugcacc accauccacu acaacuacau gugcaacucc      720

uccugcaugg gcggcaugaa ccgccgcccc auccucacca ucaucacccu cgaggacucc      780

uccggcaacc uccucggccg caacuccuuc gagguccgcg ucugcgccug ccccggccgc      840

gaccgccgca ccgaggagga gaaccuccgc aagaagggcg agccccacca cgagcucccc      900

cccggcucca ccaagcgcgc ccuccccaac aacaccuccu ccucccccca gcccaagaag      960

aagccccucg acggcgagua cuucacccuc cagauccgcg gccgcgagcg cuucgagaug     1020

uuccgcgagc ucaacgaggc ccucgagcuc aaggacgccc aggccggcaa ggagcccggc     1080

ggcucccgcg cccacuccuc ccaccucaag uccaagaagg gccaguccac cucccgccac     1140

aagaagcuca uguucaagac cgagggcccc gacuccgacu ga                        1182


<210>  3013
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       p53__Homo_sapiens__AAA59988

<400>  3013
auggaggaac cccagagcga cccuuccgug gagccaccgc ugucucaaga aaccuucuca       60

gaucucugga aacuucugcc cgagaacaau gucuugaguc cuuuaccaag ccaggccaug      120

gacgaucuga ugcuaucccc cgacgauauc gaacaguggu uuacagagga cccuggccca      180

gaugaggcuc ccagaaugcc ugaagcagcc ccaccgguug cgcccgcucc ugccgcacca      240

acucccgccg cuccugcacc agcccccucu uggccgcucu cgucaagcgu gccuagucag      300

aagacguacc aaggguccua uggauucagg cuggguuuuc uucacucugg caccgcuaag      360

agcguaacau gcacuuacuc ccccgcccug aacaaaaugu ucugucaguu ggcgaagacc      420

ugcccagugc agcucugggu cgacucaaca ccucccccag ggacccgggu gcgcgcaaug      480

gccauuuaua aacagaguca acauaugacu gagguugugc gacguugucc ccaccaugaa      540

agaugcagcg auucugacgg acuggcuccu ccacagcacc ugauaagggu cgagggcaau      600

cuccgggugg aguacuuaga ugaccgcaac acauuuagac auuccguagu ugugccguau      660

gaacccccug aggucgguuc agauuguacc acgauccacu acaauuauau gugcaacagc      720

aguuguaugg gagggaugaa uaggcggcca auucugacua ucauuacccu ugaagacucu      780

uccggcaacu ugcugggccg caauagcuuc gaggugcgag ugugcgccug ucccgggaga      840

gacaggcgga cagaagagga gaaccuacgu aagaagggag aaccucacca ugagcuccca      900

cccgguucga cuaaacgcgc acugccgaau aacaccucuu ccucaccuca gccaaagaaa      960

aagccccuug auggcgaaua cuuuacacug cagaucagag ggagggagcg guucgaaaug     1020

uuucgagagu ugaaugaggc ucucgaacug aaagacgccc aagcgggaaa ggagccuggc     1080

gguagucgcg cccacagcuc ccauuuaaag ucuaaaaagg ggcagagcac cucaagacac     1140

aaaaagcuga uguucaaaac ggaaggaccc gauagugacu ga                        1182


<210>  3014
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       p53__Homo_sapiens__AAA59988

<400>  3014
auggaggagc cccagagcga ccccagcgug gagccccccc ugagccagga gaccuucagc       60

gaccugugga agcugcugcc cgagaacaac gugcugagcc cccugcccag ccaggccaug      120

gacgaccuga ugcugagccc cgacgacauc gagcaguggu ucaccgagga ccccggcccc      180

gacgaggccc ccagaaugcc cgaggccgcc ccccccgugg cccccgcccc cgccgccccc      240

acccccgccg cccccgcccc cgcccccagc uggccccuga gcagcagcgu gcccagccag      300

aagaccuacc agggcagcua cggcuucaga cugggcuucc ugcacagcgg caccgccaag      360

agcgugaccu gcaccuacag ccccgcccug aacaagaugu ucugccagcu ggccaagacc      420

ugccccgugc agcugugggu ggacagcacc cccccccccg gcaccagagu gagagccaug      480

gccaucuaca agcagagcca gcacaugacc gaggugguga gaagaugccc ccaccacgag      540

agaugcagcg acagcgacgg ccuggccccc ccccagcacc ugaucagagu ggagggcaac      600

cugagagugg aguaccugga cgacagaaac accuucagac acagcguggu ggugcccuac      660

gagccccccg aggugggcag cgacugcacc accauccacu acaacuacau gugcaacagc      720

agcugcaugg gcggcaugaa cagaagaccc auccugacca ucaucacccu ggaggacagc      780

agcggcaacc ugcugggcag aaacagcuuc gaggugagag ugugcgccug ccccggcaga      840

gacagaagaa ccgaggagga gaaccugaga aagaagggcg agccccacca cgagcugccc      900

cccggcagca ccaagagagc ccugcccaac aacaccagca gcagccccca gcccaagaag      960

aagccccugg acggcgagua cuucacccug cagaucagag gcagagagag auucgagaug     1020

uucagagagc ugaacgaggc ccuggagcug aaggacgccc aggccggcaa ggagcccggc     1080

ggcagcagag cccacagcag ccaccugaag agcaagaagg gccagagcac cagcagacac     1140

aagaagcuga uguucaagac cgagggcccc gacagcgacu ga                        1182


<210>  3015
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       p53__Homo_sapiens__AAA59988

<400>  3015
auggaggaac cccagagcga cccuuccgug gagccgcccc ugucucaaga aaccuucagc       60

gaucucugga agcugcuucc ugagaacaau guccugucuc cccucccuuc ccaggccaug      120

gacgaucuga ugcuuagccc cgacgauauc gaacaguggu uuacagagga cccuggcccg      180

gaugaggcuc ccagaaugcc ugaagccgcg cccccuguug cucccgcccc ggccgcuccu      240

acgcccgccg cuccugcccc cgcgcccucc uggccucugu cuagcuccgu gccgagccag      300

aaaaccuacc aagggucuua uggauuccgg cucggcuuuc ugcacuccgg gacagccaag      360

agcgugaccu gcacauacuc ucccgcucug aacaaaaugu ucugucagcu cgccaagacc      420

ugcccugucc agcugugggu ggacuccaca cccccucccg gaacccgcgu uagagcuaug      480

gccauuuaua aacagagcca acauaugacg gagguggucc ggcgcugucc gcaccaugaa      540

agaugcucug auuccgacgg ccuugcgccu ccccagcacc ugauccgggu ggaggggaau      600

cuccgcguug aguaccugga ugacagaaac accuuucggc auagcguggu cgugccuuau      660

gaacccccug aggugggauc cgauuguaca accauucacu acaauuauau gugcaacucu      720

agcuguaugg gcggcaugaa ucgcagaccc auccuuacaa uuaucacccu ggaagacucc      780

agcgggaacc uccugggacg caauucuuuc gagguccggg uuugcgccug uccgggcaga      840

gaccggcgca cggaagagga gaaccugaga aagaaggggg aaccucacca ugagcucccu      900

cccggaucca caaaacgggc ucugcccaau aacaccagcu cuagcccgca gcccaagaaa      960

aagccucuug auggcgaaua cuuuacacug cagaucagag ggcgcgagcg guucgaaaug     1020

uuuagagagc ucaaugaggc ccuggaacuu aaagacgcuc aagccggaaa ggagcccggc     1080

ggcucccgcg cccacucuag ccaucugaag uccaaaaagg ggcagagcac cucucggcac     1140

aaaaagcuca uguucaaaac cgaaggaccu gauuccgacu ga                        1182


<210>  3016
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAGE-4__Homo_sapiens__O60829

<400>  3016

Met Ser Ala Arg Val Arg Ser Arg Ser Arg Gly Arg Gly Asp Gly Gln 
1               5                   10                  15      


Glu Ala Pro Asp Val Val Ala Phe Val Ala Pro Gly Glu Ser Gln Gln 
            20                  25                  30          


Glu Glu Pro Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg 
        35                  40                  45              


Glu Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln 
    50                  55                  60                  


Glu Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp 
65                  70                  75                  80  


Val Lys Glu Lys Thr Pro Pro Asn Pro Lys His Ala Lys Thr Lys Glu 
                85                  90                  95      


Ala Gly Asp Gly Gln Pro 
            100         


<210>  3017
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAGE-4__Homo_sapiens__AAF88037

<400>  3017
augagugcac gagugagauc aagauccaga ggaagaggag auggucagga ggcucccgau       60

gugguugcau ucguggcucc cggugaaucu cagcaagagg aaccaccaac ugacaaucag      120

gauauugaac cuggacaaga gagagaagga acaccuccga ucgaagaacg uaaaguagaa      180

ggugauugcc aggaaaugga ucuggaaaag acucggagug agcguggaga uggcucugau      240

guaaaagaga agacuccacc uaauccuaag caugcuaaga cuaaagaagc aggagauggg      300

cagccauaa                                                              309


<210>  3018
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAGE-4__Homo_sapiens__AAF88037

<400>  3018
augagcgccc gcgugcgguc ccgcagccgg ggccgcgggg acggccagga ggcccccgac       60

gucguggcgu ucguggcccc cggggagucc cagcaggagg agccgcccac cgacaaccag      120

gacaucgagc ccggccagga gcgggagggg accccgccca ucgaggagcg caaggucgag      180

ggcgacugcc aggagaugga ccuggagaag acgcggagcg agcgcggcga cggguccgac      240

gugaaggaga agaccccgcc caaccccaag cacgccaaga ccaaggaggc cggcgacggg      300

cagcccuga                                                              309


<210>  3019
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAGE-4__Homo_sapiens__AAF88037

<400>  3019
auguccgccc gcguccgcuc ccgcucccgc ggccgcggcg acggccagga ggcccccgac       60

gucgucgccu ucgucgcccc cggcgagucc cagcaggagg agccccccac cgacaaccag      120

gacaucgagc ccggccagga gcgcgagggc acccccccca ucgaggagcg caaggucgag      180

ggcgacugcc aggagaugga ccucgagaag acccgcuccg agcgcggcga cggcuccgac      240

gucaaggaga agaccccccc caaccccaag cacgccaaga ccaaggaggc cggcgacggc      300

cagcccuga                                                              309


<210>  3020
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAGE-4__Homo_sapiens__AAF88037

<400>  3020
augagcgcca gagugagguc ccggucucgc ggccgagggg acggacagga ggcucccgau       60

gucguugcau ucguggcccc uggugaauca caacaggagg aaccaccgac cgacaaccag      120

gauaucgagc ccggccagga acgugagggg acaccuccaa uugaggaaag aaagguagag      180

ggagacugcc aagaaaugga ucuggagaaa acuaggagug agcggggcga cgguagcgau      240

gugaaggaga aaacgccccc uaauccaaag cacgcgaaaa ccaaggaagc uggggacgga      300

cagcccuga                                                              309


<210>  3021
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAGE-4__Homo_sapiens__AAF88037

<400>  3021
augagcgcca gagugagaag cagaagcaga ggcagaggcg acggccagga ggcccccgac       60

gugguggccu ucguggcccc cggcgagagc cagcaggagg agccccccac cgacaaccag      120

gacaucgagc ccggccagga gagagagggc acccccccca ucgaggagag aaagguggag      180

ggcgacugcc aggagaugga ccuggagaag accagaagcg agagaggcga cggcagcgac      240

gugaaggaga agaccccccc caaccccaag cacgccaaga ccaaggaggc cggcgacggc      300

cagcccuga                                                              309


<210>  3022
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAGE-4__Homo_sapiens__AAF88037

<400>  3022
augagcgcca gagugcgguc ccgcucuaga ggccgcgggg acggacagga ggcucccgau       60

gucguugccu ucguggcgcc uggcgaaagc caacaggagg aaccgcccac cgacaaccag      120

gauaucgagc cugggcagga acgggaggga acacccccua uugaggaaag aaagguggag      180

ggcgacugcc aagaaaugga ucuggagaaa acgcgguccg agcgcgggga cggaucugau      240

gucaaggaga aaacaccccc uaauccgaag cacgcuaaaa ccaaggaagc cggcgacggc      300

cagcccuga                                                              309


<210>  3023
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAI-1__Homo_sapiens__P05121

<400>  3023

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  3024
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAI-1__Homo_sapiens__AAA60003

<400>  3024
augcagaugu cuccagcccu caccugccua guccugggcc uggcccuugu cuuuggugaa       60

gggucugcug ugcaccaucc cccauccuac guggcccacc uggccucaga cuucggggug      120

aggguguuuc agcagguggc gcaggccucc aaggaccgca acgugguuuu cucacccuau      180

gggguggccu cgguguuggc caugcuccag cugacaacag gaggagaaac ccagcagcag      240

auucaagcag cuaugggauu caagauugau gacaagggca uggcccccgc ccuccggcau      300

cuguacaagg agcucauggg gccauggaac aaggaugaga ucagcaccac agacgcgauc      360

uucguccagc gggaucugaa gcugguccag ggcuucaugc cccacuucuu caggcuguuc      420

cggagcacgg ucaagcaagu ggacuuuuca gagguggaga gagccagauu caucaucaau      480

gacuggguga agacacacac aaaagguaug aucagcaacu ugcuugggaa aggagccgug      540

gaccagcuga cacggcuggu gcuggugaau gcccucuacu ucaacggcca guggaagacu      600

cccuuccccg acuccagcac ccaccgccgc cucuuccaca aaucagacgg cagcacuguc      660

ucugugccca ugauggcuca gaccaacaag uucaacuaua cugaguucac cacgcccgau      720

ggccauuacu acgacauccu ggaacugccc uaccacgggg acacccucag cauguucauu      780

gcugccccuu augaaaaaga ggugccucuc ucugcccuca ccaacauucu gagugcccag      840

cucaucagcc acuggaaagg caacaugacc aggcugcccc gccuccuggu ucugcccaag      900

uucucccugg agacugaagu cgaccucagg aagccccuag agaaccuggg aaugaccgac      960

auguucagac aguuucaggc ugacuucacg agucuuucag accaagagcc ucuccacguc     1020

gcgcaggcgc ugcagaaagu gaagaucgag gugaacgaga guggcacggu ggccuccuca     1080

uccacagcug ucauagucuc agcccgcaug gcccccgagg agaucaucau ggacagaccc     1140

uuccucuuug ugguccggca caaccccaca ggaacagucc uuuucauggg ccaagugaug     1200

gaacccuga                                                             1209


<210>  3025
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAI-1__Homo_sapiens__AAA60003

<400>  3025
augcagauga gccccgcccu gaccugccuc gugcuggggc uggcccucgu cuucggggag       60

ggcuccgcgg ugcaccaccc gcccagcuac guggcccacc uggccuccga cuucgggguc      120

cgcguguucc agcaggucgc ccaggccagc aaggaccgga acgugguguu cucccccuac      180

ggcguggcga gcguccuggc caugcuccag cugaccaccg ggggcgagac gcagcagcag      240

auccaggccg ccaugggcuu caagaucgac gacaagggga uggcgcccgc ccugcgccac      300

cucuacaagg agcugauggg cccguggaac aaggacgaga ucuccaccac cgacgccauc      360

uucgugcagc gggaccugaa gcucgugcag ggguucaugc cccacuucuu ccgccuguuc      420

cggagcacgg ucaagcaggu cgacuucucc gagguggagc gcgcccgguu caucaucaac      480

gacuggguga agacccacac caagggcaug aucagcaacc ugcucgggaa gggcgccgug      540

gaccagcuga cccgccuggu gcucgucaac gcgcuguacu ucaacggcca guggaagacg      600

cccuuccccg acuccagcac ccaccggcgc cuguuccaca aguccgacgg gagcaccgug      660

uccgugccga ugauggccca gaccaacaag uucaacuaca cggaguucac cacccccgac      720

ggccacuacu acgacauccu cgagcugccc uaccacgggg acacccugag cauguucauc      780

gccgcccccu acgagaagga ggucccgcuc uccgcccuga cgaacauccu gagcgcgcag      840

cucaucuccc acuggaaggg caacaugacc cggcugcccc gccugcucgu gcugcccaag      900

uucagccugg agaccgaggu ggaccuccgg aagccccugg agaaccuggg caugaccgac      960

auguuccgcc aguuccaggc cgacuucacg agccucuccg accaggagcc gcugcacguc     1020

gcccaggccc ugcagaaggu gaagaucgag gucaacgaga gcgggaccgu ggccuccagc     1080

uccaccgcgg ugaucgucag cgcccggaug gcccccgagg agaucaucau ggaccgcccc     1140

uuccucuucg uggugcggca caaccccacc ggcacggucc uguucauggg ccaggugaug     1200

gagccguga                                                             1209


<210>  3026
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAI-1__Homo_sapiens__AAA60003

<400>  3026
augcagaugu cccccgcccu caccugccuc guccucggcc ucgcccucgu cuucggcgag       60

ggcuccgccg uccaccaccc ccccuccuac gucgcccacc ucgccuccga cuucggcguc      120

cgcgucuucc agcaggucgc ccaggccucc aaggaccgca acgucgucuu cucccccuac      180

ggcgucgccu ccguccucgc caugcuccag cucaccaccg gcggcgagac ccagcagcag      240

auccaggccg ccaugggcuu caagaucgac gacaagggca uggcccccgc ccuccgccac      300

cucuacaagg agcucauggg ccccuggaac aaggacgaga ucuccaccac cgacgccauc      360

uucguccagc gcgaccucaa gcucguccag ggcuucaugc cccacuucuu ccgccucuuc      420

cgcuccaccg ucaagcaggu cgacuucucc gaggucgagc gcgcccgcuu caucaucaac      480

gacuggguca agacccacac caagggcaug aucuccaacc uccucggcaa gggcgccguc      540

gaccagcuca cccgccucgu ccucgucaac gcccucuacu ucaacggcca guggaagacc      600

cccuuccccg acuccuccac ccaccgccgc cucuuccaca aguccgacgg cuccaccguc      660

uccgucccca ugauggccca gaccaacaag uucaacuaca ccgaguucac cacccccgac      720

ggccacuacu acgacauccu cgagcucccc uaccacggcg acacccucuc cauguucauc      780

gccgcccccu acgagaagga ggucccccuc uccgcccuca ccaacauccu cuccgcccag      840

cucaucuccc acuggaaggg caacaugacc cgccuccccc gccuccucgu ccuccccaag      900

uucucccucg agaccgaggu cgaccuccgc aagccccucg agaaccucgg caugaccgac      960

auguuccgcc aguuccaggc cgacuucacc ucccucuccg accaggagcc ccuccacguc     1020

gcccaggccc uccagaaggu caagaucgag gucaacgagu ccggcaccgu cgccuccucc     1080

uccaccgccg ucaucgucuc cgcccgcaug gcccccgagg agaucaucau ggaccgcccc     1140

uuccucuucg ucguccgcca caaccccacc ggcaccgucc ucuucauggg ccaggucaug     1200

gagcccuga                                                             1209


<210>  3027
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAI-1__Homo_sapiens__AAA60003

<400>  3027
augcagauga gccccgcccu gaccugccuc gugcuuggcc uggcuuuggu cuucggggag       60

ggauccgcag uucaccaucc uccaucuuac guggcccacu uagcgucaga cuuuggugua      120

agaguguucc aacaggucgc ucaggccagu aaggauagga acgugguuuu uagcccguau      180

ggcguggcau ccguccuggc caugcuacag cucacaacug ggggagaaac gcaacagcag      240

auccaggcug caaugggcuu caaaauugac gauaagggua uggcccccgc ucugcggcau      300

cuuuacaaag agcugauggg gccuuggaau aaggacgaaa uaucuaccac agaugccauc      360

uuugugcaac gcgacuugaa acucguacag ggauucaugc cacacuuuuu ccgacuguuu      420

cguucgacug uuaaacaggu ggauuucuca gaggucgaaa gagcgagguu uauuaucaac      480

gacuggguga agacccauac aaagggcaug auuagcaauc ugcucggcaa gggggcagug      540

gaucaguuaa cccggcuggu ccuuguuaac gccuuguauu ucaauggaca auggaaaacu      600

cccuuuccug acaguuccac acaccgcaga cuguuccaca agucugaugg uagcaccgug      660

uccguaccaa ugauggcuca gacgaacaaa uucaauuaca cugaguuuac cacacccgac      720

ggccauuauu acgauauccu agagcucccu uaucacgggg acacucuguc aauguucaua      780

gccgcaccau acgaaaagga ggugccgcuu agugcucuga ccaacaucuu gagcgcccag      840

cucauuucuc auuggaaggg aaauaugaca aggcugcccc gguuacuggu ccucccuaaa      900

uuuucccuug aaaccgaggu ggaccugcgc aagccauugg agaaccuagg caugacggau      960

auguuccgac aauuucaggc ggacuucacu ucacugagcg aucaggaacc ccuccacguu     1020

gcccaggcac ugcaaaaagu gaagaucgag gucaaugaaa gugguacagu ggcuucuucc     1080

agcaccgccg uaauuguuuc ggcuagaaug gccccugagg aaaucauaau ggacaggcca     1140

uuucuuuucg ugguccggca caaccccacu gggacagugc uguuuauggg acaggucaug     1200

gagccguga                                                             1209


<210>  3028
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAI-1__Homo_sapiens__AAA60003

<400>  3028
augcagauga gccccgcccu gaccugccug gugcugggcc uggcccuggu guucggcgag       60

ggcagcgccg ugcaccaccc ccccagcuac guggcccacc uggccagcga cuucggcgug      120

agaguguucc agcagguggc ccaggccagc aaggacagaa acgugguguu cagccccuac      180

ggcguggcca gcgugcuggc caugcugcag cugaccaccg gcggcgagac ccagcagcag      240

auccaggccg ccaugggcuu caagaucgac gacaagggca uggcccccgc ccugagacac      300

cuguacaagg agcugauggg ccccuggaac aaggacgaga ucagcaccac cgacgccauc      360

uucgugcaga gagaccugaa gcuggugcag ggcuucaugc cccacuucuu cagacuguuc      420

agaagcaccg ugaagcaggu ggacuucagc gagguggaga gagccagauu caucaucaac      480

gacuggguga agacccacac caagggcaug aucagcaacc ugcugggcaa gggcgccgug      540

gaccagcuga ccagacuggu gcuggugaac gcccuguacu ucaacggcca guggaagacc      600

cccuuccccg acagcagcac ccacagaaga cuguuccaca agagcgacgg cagcaccgug      660

agcgugccca ugauggccca gaccaacaag uucaacuaca ccgaguucac cacccccgac      720

ggccacuacu acgacauccu ggagcugccc uaccacggcg acacccugag cauguucauc      780

gccgcccccu acgagaagga ggugccccug agcgcccuga ccaacauccu gagcgcccag      840

cugaucagcc acuggaaggg caacaugacc agacugccca gacugcuggu gcugcccaag      900

uucagccugg agaccgaggu ggaccugaga aagccccugg agaaccuggg caugaccgac      960

auguucagac aguuccaggc cgacuucacc agccugagcg accaggagcc ccugcacgug     1020

gcccaggccc ugcagaaggu gaagaucgag gugaacgaga gcggcaccgu ggccagcagc     1080

agcaccgccg ugaucgugag cgccagaaug gcccccgagg agaucaucau ggacagaccc     1140

uuccuguucg uggugagaca caaccccacc ggcaccgugc uguucauggg ccaggugaug     1200

gagcccuga                                                             1209


<210>  3029
<211>  1209
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAI-1__Homo_sapiens__AAA60003

<400>  3029
augcagauga gccccgcccu gaccugccuc gugcugggcc uugcucuggu cuucggggag       60

ggauccgccg uucaccaucc uccgucuuac guggcgcacc ucgcuagcga cuuuggcgug      120

agagucuucc aacagguggc ccaggccucc aaggaucgga acguuguguu uucucccuau      180

ggggucgcua gcgugcuggc caugcuucag cugacaacgg gaggcgaaac ccaacagcag      240

auccaggcug ccaugggguu caaaauugac gauaagggaa uggcgccugc ccuccgccau      300

cuguacaaag agcugauggg ccccuggaau aaggacgaaa ucuccacaac cgaugcuauu      360

uuuguucaaa gagaccucaa acuggugcag ggcuucaugc cucacuuuuu ccggcuuuuu      420

cgcucuacag ucaaacaggu ggauuucagc gagguggaaa gagcccgguu uaucauuaac      480

gacuggguca agacccauac aaaggggaug aucuccaauc ugcucggaaa gggcgcuguu      540

gaucagcuga cccgccuugu gcuggugaac gcccucuauu ucaaugggca auggaaaacg      600

cccuuuccug acagcucuac ccacagacgg cuguuccaca aguccgaugg aagcacaguc      660

ucugugccga ugauggcgca gaccaacaaa uucaauuaca cagaguuuac cacgcccgac      720

ggccauuauu acgauauccu ggagcucccu uaucacgggg acacacuguc cauguucauu      780

gccgcucccu acgaaaagga gguuccucuu agcgcccuga ccaacauccu cucugcucag      840

cugauuuccc auuggaaggg aaauaugaca cgccuuccca gacugcucgu gcugccgaaa      900

uuuagccugg aaaccgaggu cgaccuccgg aagccucugg agaaccuugg caugaccgau      960

auguuccgcc aauuucaggc cgacuucaca ucccugucug aucaggaacc ccuccacgug     1020

gcccaggcuc ugcaaaaagu uaagaucgag gugaaugaaa gcggcacggu cgcguccagc     1080

ucuaccgccg ugauugucuc cgcuagaaug gccccugagg aaaucauuau ggaccggccc     1140

uuucuuuucg ugguucgcca caaccccaca gggaccgugc uguuuauggg acaggucaug     1200

gagccuuga                                                             1209


<210>  3030
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAI-2__Homo_sapiens__P05120

<400>  3030

Met Glu Asp Leu Cys Val Ala Asn Thr Leu Phe Ala Leu Asn Leu Phe 
1               5                   10                  15      


Lys His Leu Ala Lys Ala Ser Pro Thr Gln Asn Leu Phe Leu Ser Pro 
            20                  25                  30          


Trp Ser Ile Ser Ser Thr Met Ala Met Val Tyr Met Gly Ser Arg Gly 
        35                  40                  45              


Ser Thr Glu Asp Gln Met Ala Lys Val Leu Gln Phe Asn Glu Val Gly 
    50                  55                  60                  


Ala Asn Ala Val Thr Pro Met Thr Pro Glu Asn Phe Thr Ser Cys Gly 
65                  70                  75                  80  


Phe Met Gln Gln Ile Gln Lys Gly Ser Tyr Pro Asp Ala Ile Leu Gln 
                85                  90                  95      


Ala Gln Ala Ala Asp Lys Ile His Ser Ser Phe Arg Ser Leu Ser Ser 
            100                 105                 110         


Ala Ile Asn Ala Ser Thr Gly Asn Tyr Leu Leu Glu Ser Val Asn Lys 
        115                 120                 125             


Leu Phe Gly Glu Lys Ser Ala Ser Phe Arg Glu Glu Tyr Ile Arg Leu 
    130                 135                 140                 


Cys Gln Lys Tyr Tyr Ser Ser Glu Pro Gln Ala Val Asp Phe Leu Glu 
145                 150                 155                 160 


Cys Ala Glu Glu Ala Arg Lys Lys Ile Asn Ser Trp Val Lys Thr Gln 
                165                 170                 175     


Thr Lys Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly 
            180                 185                 190         


Asp Thr Arg Met Val Leu Val Asn Ala Val Tyr Phe Lys Gly Lys Trp 
        195                 200                 205             


Lys Thr Pro Phe Glu Lys Lys Leu Asn Gly Leu Tyr Pro Phe Arg Val 
    210                 215                 220                 


Asn Ser Ala Gln Arg Thr Pro Val Gln Met Met Tyr Leu Arg Glu Lys 
225                 230                 235                 240 


Leu Asn Ile Gly Tyr Ile Glu Asp Leu Lys Ala Gln Ile Leu Glu Leu 
                245                 250                 255     


Pro Tyr Ala Gly Asp Val Ser Met Phe Leu Leu Leu Pro Asp Glu Ile 
            260                 265                 270         


Ala Asp Val Ser Thr Gly Leu Glu Leu Leu Glu Ser Glu Ile Thr Tyr 
        275                 280                 285             


Asp Lys Leu Asn Lys Trp Thr Ser Lys Asp Lys Met Ala Glu Asp Glu 
    290                 295                 300                 


Val Glu Val Tyr Ile Pro Gln Phe Lys Leu Glu Glu His Tyr Glu Leu 
305                 310                 315                 320 


Arg Ser Ile Leu Arg Ser Met Gly Met Glu Asp Ala Phe Asn Lys Gly 
                325                 330                 335     


Arg Ala Asn Phe Ser Gly Met Ser Glu Arg Asn Asp Leu Phe Leu Ser 
            340                 345                 350         


Glu Val Phe His Gln Ala Met Val Asp Val Asn Glu Glu Gly Thr Glu 
        355                 360                 365             


Ala Ala Ala Gly Thr Gly Gly Val Met Thr Gly Arg Thr Gly His Gly 
    370                 375                 380                 


Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Leu Ile Met His 
385                 390                 395                 400 


Lys Ile Thr Asn Cys Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 
                405                 410                 415 


<210>  3031
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAI-2__Homo_sapiens__AAA36797

<400>  3031
auggaggauc uuuguguggc aaacacacuc uuugcccuca auuuauucaa gcaucuggca       60

aaagcaagcc ccacccagaa ccucuuccuc uccccaugga gcaucucguc caccauggcc      120

auggucuaca ugggcuccag gggcagcacc gaagaccaga uggccaaggu gcuucaguuu      180

aaugaagugg gagccaaugc aguuaccccc augacuccag agaacuuuac cagcuguggg      240

uucaugcagc agauccagaa ggguaguuau ccugaugcga uuuugcaggc acaagcugca      300

gauaaaaucc auucauccuu ccgcucucuc agcucugcaa ucaaugcauc cacagggaau      360

uauuuacugg aaagugucaa uaagcuguuu ggugagaagu cugcgagcuu ccgggaagaa      420

uauauucgac ucugucagaa auauuacucc ucagaacccc aggcaguaga cuuccuagaa      480

ugugcagaag aagcuagaaa aaagauuaau uccuggguca agacucaaac caaaggcaaa      540

aucccaaacu uguuaccuga agguucugua gauggggaua ccaggauggu ccuggugaau      600

gcugucuacu ucaaaggaaa guggaaaacu ccauuugaga agaaacuaaa ugggcuuuau      660

ccuuuccgug uaaacucggc ucagcgcaca ccuguacaga ugauguacuu gcgugaaaag      720

cuaaacauug gauacauaga agaccuaaag gcucagauuc uagaacuccc auaugcugga      780

gauguuagca uguucuuguu gcuuccagau gaaauugccg auguguccac uggcuuggag      840

cugcuggaaa gugaaauaac cuaugacaaa cucaacaagu ggaccagcaa agacaaaaug      900

gcugaagaug aaguugaggu auacauaccc caguucaaau uagaagagca uuaugaacuc      960

agauccauuc ugagaagcau gggcauggag gacgccuuca acaagggacg ggccaauuuc     1020

ucagggaugu cggagaggaa ugaccuguuu cuuucugaag uguuccacca agccauggug     1080

gaugugaaug aggagggcac ugaagcagcc gcuggcacag gagguguuau gacagggaga     1140

acuggacaug gaggcccaca guuuguggca gaucauccuu uucuuuuucu uauuaugcau     1200

aagauaacca acugcauuuu auuuuucggc agauuuuccu cacccuaa                  1248


<210>  3032
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAI-2__Homo_sapiens__AAA36797

<400>  3032
auggaggacc ugugcguggc caacacccuc uucgcccuga accuguucaa gcaccucgcg       60

aaggccagcc ccacccagaa ccuguuccug uccccgugga gcaucuccag cacgauggcc      120

auggucuaca ugggcucccg cgggagcacc gaggaccaga uggccaaggu gcuccaguuc      180

aacgaggugg gcgccaacgc ggucaccccc augacccccg agaacuucac guccugcggg      240

uucaugcagc agauccagaa gggcagcuac cccgacgcca uccugcaggc ccaggccgcg      300

gacaagaucc acuccagcuu ccggucccug agcuccgcca ucaacgccag caccgggaac      360

uaccuccugg aguccgugaa caagcuguuc ggcgagaagu ccgccagcuu ccgcgaggag      420

uacauccggc ucugccagaa guacuacagc uccgagccgc aggccgugga cuuccuggag      480

ugcgcggagg aggcccgcaa gaagaucaac agcuggguca agacccagac caagggcaag      540

auccccaacc ugcuccccga ggggagcgug gacggcgaca cgcggauggu gcuggucaac      600

gccguguacu ucaaggggaa guggaagacc cccuucgaga agaagcugaa cggccucuac      660

ccguuccgcg ugaacuccgc ccagcggacc cccguccaga ugauguaccu gcgcgagaag      720

cugaacaucg gguacaucga ggaccucaag gcccagaucc uggagcugcc cuacgcgggc      780

gacgugagca uguuccuccu gcugcccgac gagaucgccg acguguccac cggccucgag      840

cugcuggaga gcgagaucac guacgacaag cucaacaagu ggaccuccaa ggacaagaug      900

gccgaggacg aggucgaggu guacaucccg caguucaagc uggaggagca cuacgagcug      960

cggagcaucc uccgcuccau ggggauggag gacgccuuca acaagggccg ggccaacuuc     1020

agcgggaugu ccgagcgcaa cgaccuguuc cugagcgagg uguuccacca ggcgaugguc     1080

gacgugaacg aggagggcac cgaggccgcc gccggcaccg ggggcgugau gacggggcgg     1140

accggccacg ggggccccca guucgucgcc gaccaccccu uccucuuccu gaucaugcac     1200

aagaucacca acugcauccu guucuucggc cgcuucucca gccccuga                  1248


<210>  3033
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAI-2__Homo_sapiens__AAA36797

<400>  3033
auggaggacc ucugcgucgc caacacccuc uucgcccuca accucuucaa gcaccucgcc       60

aaggccuccc ccacccagaa ccucuuccuc ucccccuggu ccaucuccuc caccauggcc      120

auggucuaca ugggcucccg cggcuccacc gaggaccaga uggccaaggu ccuccaguuc      180

aacgaggucg gcgccaacgc cgucaccccc augacccccg agaacuucac cuccugcggc      240

uucaugcagc agauccagaa gggcuccuac cccgacgcca uccuccaggc ccaggccgcc      300

gacaagaucc acuccuccuu ccgcucccuc uccuccgcca ucaacgccuc caccggcaac      360

uaccuccucg aguccgucaa caagcucuuc ggcgagaagu ccgccuccuu ccgcgaggag      420

uacauccgcc ucugccagaa guacuacucc uccgagcccc aggccgucga cuuccucgag      480

ugcgccgagg aggcccgcaa gaagaucaac uccuggguca agacccagac caagggcaag      540

auccccaacc uccuccccga gggcuccguc gacggcgaca cccgcauggu ccucgucaac      600

gccgucuacu ucaagggcaa guggaagacc cccuucgaga agaagcucaa cggccucuac      660

cccuuccgcg ucaacuccgc ccagcgcacc cccguccaga ugauguaccu ccgcgagaag      720

cucaacaucg gcuacaucga ggaccucaag gcccagaucc ucgagcuccc cuacgccggc      780

gacgucucca uguuccuccu ccuccccgac gagaucgccg acgucuccac cggccucgag      840

cuccucgagu ccgagaucac cuacgacaag cucaacaagu ggaccuccaa ggacaagaug      900

gccgaggacg aggucgaggu cuacaucccc caguucaagc ucgaggagca cuacgagcuc      960

cgcuccaucc uccgcuccau gggcauggag gacgccuuca acaagggccg cgccaacuuc     1020

uccggcaugu ccgagcgcaa cgaccucuuc cucuccgagg ucuuccacca ggccaugguc     1080

gacgucaacg aggagggcac cgaggccgcc gccggcaccg gcggcgucau gaccggccgc     1140

accggccacg gcggccccca guucgucgcc gaccaccccu uccucuuccu caucaugcac     1200

aagaucacca acugcauccu cuucuucggc cgcuucuccu cccccuga                  1248


<210>  3034
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAI-2__Homo_sapiens__AAA36797

<400>  3034
auggaggacc ugugcguggc caacacccuc uucgcucuua aucuguuuaa gcacuuggca       60

aaagccagcc ccacacagaa cuuauuccug uccccuuggu cuaucucaag uacuauggcg      120

auggucuaca ugggcagcag aggguccacg gaagaucaaa uggcuaaggu ucuacaguuu      180

aaugaggugg gagccaacgc aguaacccca augacaccgg aaaauuucac uucuuguggu      240

uuuaugcagc agauucaaaa aggcucguau cccgacgcca uacuccaggc ucaggcagcc      300

gauaagaucc auagcucauu caggagucug uccucugcua uuaacgccag caccgggaau      360

uaccuucugg aguccgugaa caaauuguuu ggagaaaagu cagcgaguuu ccgggaggag      420

uauauccgcc ucugccagaa guacuauagc ucugaaccuc aagcagucga cuuucuggag      480

ugugccgaag aggcucguaa aaagauuaau uccuggguga aaacacagac caagggcaaa      540

aucccaaacc ugcuccccga ggguucaguu gauggggaca cucgaauggu guuagucaau      600

gccguguacu ucaagggaaa guggaaaaca ccuuuugaaa agaaacugaa cggccuuuau      660

ccauucagag uaaauagcgc acagaggacc cccguucaga ugauguacuu gcgggagaag      720

cugaacauag gcuacaucga agaucuaaaa gcucaaauuc ucgagcugcc uuaugccggg      780

gacgugagua uguuucuucu guugccagau gaaaucgcgg acgucucuac gggacucgag      840

cuguuagagu ccgaaauuac uuacgauaag cugaauaaau ggaccagcaa ggacaagaug      900

gccgaggaug aaguggaggu guauaucccg caguucaaac ucgaggaaca cuacgagcuu      960

cgcucgauac ugagaucuau ggguauggaa gacgcauuca acaagggcag ggcuaacuuu     1020

uccgggaugu cagagcggaa ugacuuguuc cuaagugaag ucuuucauca ggccaugguu     1080

gaugugaacg aggaaggaac agaggcugcc gcaggcacug gugggguaau gaccggacgc     1140

acaggccacg gcgggcccca auucguggcc gaccauccuu uucuguuccu cauuaugcac     1200

aaaaucacca auugcauucu guuuuucgga cgauuuagcu ccccauga                  1248


<210>  3035
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAI-2__Homo_sapiens__AAA36797

<400>  3035
auggaggacc ugugcguggc caacacccug uucgcccuga accuguucaa gcaccuggcc       60

aaggccagcc ccacccagaa ccuguuccug agccccugga gcaucagcag caccauggcc      120

augguguaca ugggcagcag aggcagcacc gaggaccaga uggccaaggu gcugcaguuc      180

aacgaggugg gcgccaacgc cgugaccccc augacccccg agaacuucac cagcugcggc      240

uucaugcagc agauccagaa gggcagcuac cccgacgcca uccugcaggc ccaggccgcc      300

gacaagaucc acagcagcuu cagaagccug agcagcgcca ucaacgccag caccggcaac      360

uaccugcugg agagcgugaa caagcuguuc ggcgagaaga gcgccagcuu cagagaggag      420

uacaucagac ugugccagaa guacuacagc agcgagcccc aggccgugga cuuccuggag      480

ugcgccgagg aggccagaaa gaagaucaac agcuggguga agacccagac caagggcaag      540

auccccaacc ugcugcccga gggcagcgug gacggcgaca ccagaauggu gcuggugaac      600

gccguguacu ucaagggcaa guggaagacc cccuucgaga agaagcugaa cggccuguac      660

cccuucagag ugaacagcgc ccagagaacc cccgugcaga ugauguaccu gagagagaag      720

cugaacaucg gcuacaucga ggaccugaag gcccagaucc uggagcugcc cuacgccggc      780

gacgugagca uguuccugcu gcugcccgac gagaucgccg acgugagcac cggccuggag      840

cugcuggaga gcgagaucac cuacgacaag cugaacaagu ggaccagcaa ggacaagaug      900

gccgaggacg agguggaggu guacaucccc caguucaagc uggaggagca cuacgagcug      960

agaagcaucc ugagaagcau gggcauggag gacgccuuca acaagggcag agccaacuuc     1020

agcggcauga gcgagagaaa cgaccuguuc cugagcgagg uguuccacca ggccauggug     1080

gacgugaacg aggagggcac cgaggccgcc gccggcaccg gcggcgugau gaccggcaga     1140

accggccacg gcggccccca guucguggcc gaccaccccu uccuguuccu gaucaugcac     1200

aagaucacca acugcauccu guucuucggc agauucagca gccccuga                  1248


<210>  3036
<211>  1248
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAI-2__Homo_sapiens__AAA36797

<400>  3036
auggaggacc ugugcguggc caacacccuc uucgcucuga aucuuuuuaa gcaccuggcc       60

aaagcgagcc ccacacagaa ccucuuccug uccccuuggu cuaucagcuc cacgauggcu      120

auggucuaca ugggcucuag agggagcacc gaagaucaaa uggccaaggu ucuucaguuu      180

aaugaggugg gagccaacgc ugugacaccg augacccccg aaaauuucac auccuguggc      240

uuuaugcagc agauucaaaa agggucuuau ccugacgcca uccugcaggc ucaggccgcg      300

gauaagauuc auagcuccuu ccggagccuc ucuuccgcca ucaacgcuag caccggaaau      360

uaccugcugg agucugucaa caaacucuuu ggcgaaaagu ccgccagcuu ccgcgaggag      420

uauauuagac ugugccagaa guacuauucu uccgaacccc aagcugugga cuuucuugag      480

ugugccgaag aggcgcggaa aaagaucaau agcuggguua aaacacagac caaggggaaa      540

aucccuaacc ugcuccccga gggauccgug gauggcgaca cgcgcauggu ccuggugaau      600

gccguuuacu ucaagggcaa guggaaaacc ccuuuugaaa agaaacuuaa cgggcuguau      660

ccguucagag ucaauucugc ucagcggaca cccgugcaga ugauguaccu ccgcgagaag      720

cugaacauug gauacaucga agaucugaaa gcccaaauuc ucgagcugcc uuaugcuggc      780

gacgugagca uguuucuucu gcuccccgau gaaaucgccg acguguccac cgggcuggag      840

cuucuggaga gcgaaauuac auacgauaag cucaauaaau ggaccucuaa ggacaagaug      900

gccgaggaug aagucgaggu uuauaucccu caguucaaac uggaggaaca cuacgagcug      960

agauccauuc uccggagcau gggaauggaa gacgcuuuca acaagggccg cgcgaacuuu     1020

ucugggauga gcgagagaaa ugaccuguuc cuuuccgaag uguuucauca ggccauggug     1080

gaugucaacg aggaaggaac ggaggcugcc gccggcacag gcggggugau gaccggacgg     1140

acaggccacg ggggacccca auucguugcu gaccauccgu uucuguuccu caucaugcac     1200

aaaaucacca auugcauucu guuuuucggc cgcuuuucua gcccuuga                  1248


<210>  3037
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAP__Homo_sapiens__Q06141

<400>  3037

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  3038
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAP__Homo_sapiens__AAA60020

<400>  3038
augcugccuc ccauggcccu gcccagugua ucuuggaugc ugcuuuccug ccucaugcug       60

cugucucagg uucaagguga agaaccccag agggaacugc ccucugcacg gauccgcugu      120

cccaaaggcu ccaaggccua uggcucccac ugcuaugccu uguuuuuguc accaaaaucc      180

uggacagaug cagaucuggc cugccagaag cggcccucug gaaaccuggu gucugugcuc      240

aguggggcug agggauccuu cguguccucc cuggugaaga gcauugguaa cagcuacuca      300

uacgucugga uugggcucca ugaccccaca cagggcaccg agcccaaugg agaagguugg      360

gaguggagua gcagugaugu gaugaauuac uuugcauggg agagaaaucc cuccaccauc      420

ucaagccccg gccacugugc gagccugucg agaagcacag cauuucugag guggaaagau      480

uauaacugua augugagguu acccuauguc ugcaaguuca cugacuag                   528


<210>  3039
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAP__Homo_sapiens__AAA60020

<400>  3039
augcugcccc cgauggcccu ccccagcgug uccuggaugc ugcugagcug ccucaugcug       60

cugucccagg uccagggcga ggagccccag cgcgagcucc ccagcgcccg gauccgcugc      120

ccgaaggggu ccaaggcgua cggcagccac ugcuacgccc uguuccuguc ccccaagagc      180

uggaccgacg ccgaccucgc cugccagaag cggcccuccg ggaaccuggu gagcgugcug      240

uccggcgccg aggggagcuu cgucuccagc cucgugaagu ccaucggcaa cagcuacucc      300

uacgugugga ucggccugca cgaccccacc caggggacgg agccgaacgg cgaggggugg      360

gaguggagcu ccagcgacgu caugaacuac uucgcguggg agcgcaaccc cagcaccauc      420

uccagccccg gccacugcgc cucccugagc cgguccaccg ccuuccuccg cuggaaggac      480

uacaacugca acgugcggcu gcccuacgug ugcaaguuca ccgacuga                   528


<210>  3040
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAP__Homo_sapiens__AAA60020

<400>  3040
augcuccccc ccauggcccu ccccuccguc uccuggaugc uccucuccug ccucaugcuc       60

cucucccagg uccagggcga ggagccccag cgcgagcucc ccuccgcccg cauccgcugc      120

cccaagggcu ccaaggccua cggcucccac ugcuacgccc ucuuccucuc ccccaagucc      180

uggaccgacg ccgaccucgc cugccagaag cgccccuccg gcaaccucgu cuccguccuc      240

uccggcgccg agggcuccuu cgucuccucc cucgucaagu ccaucggcaa cuccuacucc      300

uacgucugga ucggccucca cgaccccacc cagggcaccg agcccaacgg cgagggcugg      360

gagugguccu ccuccgacgu caugaacuac uucgccuggg agcgcaaccc cuccaccauc      420

uccucccccg gccacugcgc cucccucucc cgcuccaccg ccuuccuccg cuggaaggac      480

uacaacugca acguccgccu ccccuacguc ugcaaguuca ccgacuga                   528


<210>  3041
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAP__Homo_sapiens__AAA60020

<400>  3041
augcugcccc cuauggcccu cccaagcgug uccuggaugc uucugucuug cuugauguua       60

cugucacagg uccaaggcga ggaaccgcag agagagcuac ccagugcuag gauccggugu      120

ccuaagggga gcaaagcaua cggaucccac ugcuaugccc ucuuccuguc uccaaagucg      180

uggaccgacg cggaucuugc uugucagaaa cgccccucag guaaccuggu uagcguguug      240

aguggcgccg aaggguccuu uguaucuagc cucgugaagu ccauuggaaa uucauacagu      300

uaugucugga uaggccugca ugacccuaca caggguacug agccaaacgg ggaaggaugg      360

gaguggucua gcuccgaugu gaugaauuac uucgcauggg agcgaaaccc cucaacgauc      420

agcaguccug gccacugcgc cucucugucc cguagcaccg cuuuucucag auggaaagac      480

uauaauugua acguuagguu accauacgug ugcaaguuca cagauuga                   528


<210>  3042
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAP__Homo_sapiens__AAA60020

<400>  3042
augcugcccc ccauggcccu gcccagcgug agcuggaugc ugcugagcug ccugaugcug       60

cugagccagg ugcagggcga ggagccccag agagagcugc ccagcgccag aaucagaugc      120

cccaagggca gcaaggccua cggcagccac ugcuacgccc uguuccugag ccccaagagc      180

uggaccgacg ccgaccuggc cugccagaag agacccagcg gcaaccuggu gagcgugcug      240

agcggcgccg agggcagcuu cgugagcagc cuggugaaga gcaucggcaa cagcuacagc      300

uacgugugga ucggccugca cgaccccacc cagggcaccg agcccaacgg cgagggcugg      360

gaguggagca gcagcgacgu gaugaacuac uucgccuggg agagaaaccc cagcaccauc      420

agcagccccg gccacugcgc cagccugagc agaagcaccg ccuuccugag auggaaggac      480

uacaacugca acgugagacu gcccuacgug ugcaaguuca ccgacuga                   528


<210>  3043
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAP__Homo_sapiens__AAA60020

<400>  3043
augcugcccc cuauggcccu cccgagcgug uccuggaugc ugcuuucuug ccugaugcuc       60

cugagccagg uccaaggcga ggaaccccag agagagcuuc cuuccgcucg gauccgcugu      120

cccaaggggu cuaaagccua cggaagccac ugcuaugcgc uguuccucuc cccuaagucu      180

uggaccgacg cugaucuggc cugucagaaa agacccagcg gcaaccuggu uuccgugcuc      240

agcggggccg aaggaucuuu uguguccagc cuggucaagu cuauuggcaa uuccuacagc      300

uaugugugga ucgggcuuca ugacccuaca cagggaacgg agccgaacgg cgaaggcugg      360

gaguggucuu ccagcgaugu uaugaauuac uucgcuuggg agcggaaccc cuccaccauu      420

ucuagcccug ggcacugcgc cucccugagc cgcucuacag cuuuucucag auggaaagac      480

uauaauugua acgugcggcu gcccuacguc ugcaaguuca ccgauuga                   528


<210>  3044
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAP__Homo_sapiens__Q53S56

<400>  3044

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  3045
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAP__Homo_sapiens__AAT11159

<400>  3045
augcugccuc ccauggcccu gcccagugua ucuuggaugc ugcuuuccug ccucaugcug       60

cugucucagg uucaagguga agaaccccag agggaacugc ccucugcacg gauccgcugu      120

cccaaaggcu ccaaggccua uggcucccac ugcuaugccu uguuuuuguc accaaaaucc      180

uggacagaug cagaucuggc cugccagaag cggcccucug gaaaccuggu gucugugcuc      240

aguggggcug agggauccuu cguguccucc cuggugaaga gcauugguaa cagcuacuca      300

uacgucugga uugggcucca ugaccccaca cagggcaccg agcccaaugg agaagguugg      360

gaguggagua gcagugaugu gaugaauuac uuugcauggg agagaaaucc cuccaccauc      420

ucaagccccg gccacugugc gagccugucg agaagcacag cauuucugag guggaaagau      480

uauaacugua augugagguu acccuauguc ugcaaguuca cugacuag                   528


<210>  3046
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAP__Homo_sapiens__AAT11159

<400>  3046
augcugcccc cgauggcccu ccccagcgug uccuggaugc ugcugagcug ccucaugcug       60

cugucccagg uccagggcga ggagccccag cgcgagcucc ccagcgcccg gauccgcugc      120

ccgaaggggu ccaaggcgua cggcagccac ugcuacgccc uguuccuguc ccccaagagc      180

uggaccgacg ccgaccucgc cugccagaag cggcccuccg ggaaccuggu gagcgugcug      240

uccggcgccg aggggagcuu cgucuccagc cucgugaagu ccaucggcaa cagcuacucc      300

uacgugugga ucggccugca cgaccccacc caggggacgg agccgaacgg cgaggggugg      360

gaguggagcu ccagcgacgu caugaacuac uucgcguggg agcgcaaccc cagcaccauc      420

uccagccccg gccacugcgc cucccugagc cgguccaccg ccuuccuccg cuggaaggac      480

uacaacugca acgugcggcu gcccuacgug ugcaaguuca ccgacuga                   528


<210>  3047
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAP__Homo_sapiens__AAT11159

<400>  3047
augcuccccc ccauggcccu ccccuccguc uccuggaugc uccucuccug ccucaugcuc       60

cucucccagg uccagggcga ggagccccag cgcgagcucc ccuccgcccg cauccgcugc      120

cccaagggcu ccaaggccua cggcucccac ugcuacgccc ucuuccucuc ccccaagucc      180

uggaccgacg ccgaccucgc cugccagaag cgccccuccg gcaaccucgu cuccguccuc      240

uccggcgccg agggcuccuu cgucuccucc cucgucaagu ccaucggcaa cuccuacucc      300

uacgucugga ucggccucca cgaccccacc cagggcaccg agcccaacgg cgagggcugg      360

gagugguccu ccuccgacgu caugaacuac uucgccuggg agcgcaaccc cuccaccauc      420

uccucccccg gccacugcgc cucccucucc cgcuccaccg ccuuccuccg cuggaaggac      480

uacaacugca acguccgccu ccccuacguc ugcaaguuca ccgacuga                   528


<210>  3048
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAP__Homo_sapiens__AAT11159

<400>  3048
augcugcccc cuauggcccu cccaagcgug uccuggaugc uucugucuug cuugauguua       60

cugucacagg uccaaggcga ggaaccgcag agagagcuac ccagugcuag gauccggugu      120

ccuaagggga gcaaagcaua cggaucccac ugcuaugccc ucuuccuguc uccaaagucg      180

uggaccgacg cggaucuugc uugucagaaa cgccccucag guaaccuggu uagcguguug      240

aguggcgccg aaggguccuu uguaucuagc cucgugaagu ccauuggaaa uucauacagu      300

uaugucugga uaggccugca ugacccuaca caggguacug agccaaacgg ggaaggaugg      360

gaguggucua gcuccgaugu gaugaauuac uucgcauggg agcgaaaccc cucaacgauc      420

agcaguccug gccacugcgc cucucugucc cguagcaccg cuuuucucag auggaaagac      480

uauaauugua acguuagguu accauacgug ugcaaguuca cagauuga                   528


<210>  3049
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAP__Homo_sapiens__AAT11159

<400>  3049
augcugcccc ccauggcccu gcccagcgug agcuggaugc ugcugagcug ccugaugcug       60

cugagccagg ugcagggcga ggagccccag agagagcugc ccagcgccag aaucagaugc      120

cccaagggca gcaaggccua cggcagccac ugcuacgccc uguuccugag ccccaagagc      180

uggaccgacg ccgaccuggc cugccagaag agacccagcg gcaaccuggu gagcgugcug      240

agcggcgccg agggcagcuu cgugagcagc cuggugaaga gcaucggcaa cagcuacagc      300

uacgugugga ucggccugca cgaccccacc cagggcaccg agcccaacgg cgagggcugg      360

gaguggagca gcagcgacgu gaugaacuac uucgccuggg agagaaaccc cagcaccauc      420

agcagccccg gccacugcgc cagccugagc agaagcaccg ccuuccugag auggaaggac      480

uacaacugca acgugagacu gcccuacgug ugcaaguuca ccgacuga                   528


<210>  3050
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAP__Homo_sapiens__AAT11159

<400>  3050
augcugcccc cuauggcccu cccgagcgug uccuggaugc ugcuuucuug ccugaugcuc       60

cugagccagg uccaaggcga ggaaccccag agagagcuuc cuuccgcucg gauccgcugu      120

cccaaggggu cuaaagccua cggaagccac ugcuaugcgc uguuccucuc cccuaagucu      180

uggaccgacg cugaucuggc cugucagaaa agacccagcg gcaaccuggu uuccgugcuc      240

agcggggccg aaggaucuuu uguguccagc cuggucaagu cuauuggcaa uuccuacagc      300

uaugugugga ucgggcuuca ugacccuaca cagggaacgg agccgaacgg cgaaggcugg      360

gaguggucuu ccagcgaugu uaugaauuac uucgcuuggg agcggaaccc cuccaccauu      420

ucuagcccug ggcacugcgc cucccugagc cgcucuacag cuuuucucag auggaaagac      480

uauaauugua acgugcggcu gcccuacguc ugcaaguuca ccgauuga                   528


<210>  3051
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PATE__Homo_sapiens__Q8WXA2

<400>  3051

Met Asp Lys Ser Leu Leu Leu Glu Leu Pro Ile Leu Leu Cys Cys Phe 
1               5                   10                  15      


Arg Ala Leu Ser Gly Ser Leu Ser Met Arg Asn Asp Ala Val Asn Glu 
            20                  25                  30          


Ile Val Ala Val Lys Asn Asn Phe Pro Val Ile Glu Ile Val Gln Cys 
        35                  40                  45              


Arg Met Cys His Leu Gln Phe Pro Gly Glu Lys Cys Ser Arg Gly Arg 
    50                  55                  60                  


Gly Ile Cys Thr Ala Thr Thr Glu Glu Ala Cys Met Val Gly Arg Met 
65                  70                  75                  80  


Phe Lys Arg Asp Gly Asn Pro Trp Leu Thr Phe Met Gly Cys Leu Lys 
                85                  90                  95      


Asn Cys Ala Asp Val Lys Gly Ile Arg Trp Ser Val Tyr Leu Val Asn 
            100                 105                 110         


Phe Arg Cys Cys Arg Ser His Asp Leu Cys Asn Glu Asp Leu 
        115                 120                 125     


<210>  3052
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PATE__Homo_sapiens__AAH39863

<400>  3052
auggacaagu cccucuugcu ggaacucccc auccugcucu gcugcuuuag ggcauuaucu       60

ggaucacuuu caaugagaaa ugaugcaguc aaugaaauag uugcugugaa aaacaauuuu      120

ccugugauag aaauuguuca guguaggaug ugccaccucc aguucccagg agaaaagugc      180

uccagaggaa gaggaauaug cacagcaaca acagaagagg ccugcauggu uggaaggaug      240

uucaaaaggg augguaaucc cugguuaacc uucaugggcu gccuaaagaa cugugcugau      300

gugaaaggca uaagguggag ugucuauuug gugaacuuca ggugcugcag gagccaugac      360

cugugcaaug aagaccuuua g                                                381


<210>  3053
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PATE__Homo_sapiens__AAH39863

<400>  3053
auggacaaga gccugcuccu ggagcugccc auccuccugu gcugcuuccg cgcccugucc       60

ggcagccucu ccaugcggaa cgacgccgug aacgagaucg ucgcggugaa gaacaacuuc      120

ccggugaucg agaucgucca gugccgcaug ugccaccucc aguuccccgg ggagaagugc      180

agccggggcc gcgggaucug caccgccacc acggaggagg ccugcauggu gggccggaug      240

uucaagcgcg acgggaaccc cuggcugacc uucaugggcu gccugaagaa cugcgccgac      300

gugaagggca uccggugguc cgucuaccug gugaacuucc gcugcugccg gagccacgac      360

cugugcaacg aggaccucug a                                                381


<210>  3054
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PATE__Homo_sapiens__AAH39863

<400>  3054
auggacaagu cccuccuccu cgagcucccc auccuccucu gcugcuuccg cgcccucucc       60

ggcucccucu ccaugcgcaa cgacgccguc aacgagaucg ucgccgucaa gaacaacuuc      120

cccgucaucg agaucgucca gugccgcaug ugccaccucc aguuccccgg cgagaagugc      180

ucccgcggcc gcggcaucug caccgccacc accgaggagg ccugcauggu cggccgcaug      240

uucaagcgcg acggcaaccc cuggcucacc uucaugggcu gccucaagaa cugcgccgac      300

gucaagggca uccgcugguc cgucuaccuc gucaacuucc gcugcugccg cucccacgac      360

cucugcaacg aggaccucug a                                                381


<210>  3055
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PATE__Homo_sapiens__AAH39863

<400>  3055
auggacaaga gccugcuccu ugagcugccc aucuuguuau gcuguuucag agcccugucc       60

ggcucucuau caaugaggaa cgaugcugug aaugaaauug ucgcaguuaa aaacaauuuu      120

ccugugauag agaucguaca gugccggaug ugucaccucc aauucccagg ggaaaagugc      180

agucgcggac gagguauuug uaccgccaca acugaggaag cgugcauggu gggccguaug      240

uuuaaaagag acgggaaccc guggcugacg uucaugggau gucuuaagaa uugcgcugau      300

gucaaaggca ucagguggag cguguaccug guuaacuuuc gguguugccg cucccaugac      360

uuguguaaug aggaucucug a                                                381


<210>  3056
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PATE__Homo_sapiens__AAH39863

<400>  3056
auggacaaga gccugcugcu ggagcugccc auccugcugu gcugcuucag agcccugagc       60

ggcagccuga gcaugagaaa cgacgccgug aacgagaucg uggccgugaa gaacaacuuc      120

cccgugaucg agaucgugca gugcagaaug ugccaccugc aguuccccgg cgagaagugc      180

agcagaggca gaggcaucug caccgccacc accgaggagg ccugcauggu gggcagaaug      240

uucaagagag acggcaaccc cuggcugacc uucaugggcu gccugaagaa cugcgccgac      300

gugaagggca ucagauggag cguguaccug gugaacuuca gaugcugcag aagccacgac      360

cugugcaacg aggaccugug a                                                381


<210>  3057
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PATE__Homo_sapiens__AAH39863

<400>  3057
auggacaaga gccugcuccu ggagcuuccc auccugcucu gcuguuucag agcccugucc       60

ggcucucuua gcaugcggaa cgaugcugug aaugaaauug ucgccguuaa aaacaauuuu      120

ccugugaucg agauugugca gugccgcaug ugucaucugc aauucccggg ggaaaagugc      180

uccagaggac ggggcaucug uaccgcgaca acggaggagg cuugcauggu cgggcgcaug      240

uuuaaaagag acggaaaccc cuggcucacc uucaugggcu gucugaagaa uugcgccgau      300

gugaaaggga uucggugguc uguuuaccug gugaacuuuc gcuguugcag aagccacgac      360

cucuguaaug aagaucugug a                                                381


<210>  3058
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAX3__Homo_sapiens__P23760

<400>  3058

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly 
385                 390                 395                 400 


Gly Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr 
                405                 410                 415     


Gly Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg 
            420                 425                 430         


Leu Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr 
        435                 440                 445             


Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr 
    450                 455                 460                 


Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Lys Pro Trp Thr Phe 
465                 470                 475                 


<210>  3059
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAX3__Homo_sapiens__CCDS42826.1

<400>  3059
augaccacgc uggccggcgc ugugcccagg augaugcggc cgggcccggg gcagaacuac       60

ccgcguagcg gguucccgcu ggaagugucc acuccccucg gccagggccg cgucaaccag      120

cucggcggug uuuuuaucaa cggcaggccg cugcccaacc acauccgcca caagaucgug      180

gagauggccc accacggcau ccggcccugc gucaucucgc gccagcugcg cgugucccac      240

ggcugcgucu ccaagauccu gugcagguac caggagacug gcuccauacg uccuggugcc      300

aucggcggca gcaagcccaa gcaggugaca acgccugacg uggagaagaa aauugaggaa      360

uacaaaagag agaacccggg cauguucagc ugggaaaucc gagacaaauu acucaaggac      420

gcggucugug aucgaaacac cgugccguca gugaguucca ucagccgcau ccugagaagu      480

aaauucggga aaggugaaga ggaggaggcc gacuuggaga ggaaggaggc agaggaaagc      540

gagaagaagg ccaaacacag caucgacggc auccugagcg agcgagccuc agcaccccaa      600

ucagaugaag gcucugauau ugacucugaa ccagauuuac cacuaaagag gaaacagcgc      660

agaagccgaa ccaccuucac agcagaacag cuggaggaac uggagcgugc uuuugagaga      720

acucauuacc cugacauuua uacuagggag gaacuggccc agagggcgaa gcucaccgag      780

gcccgaguac aggucugguu uagcaaccgc cgugcaagau ggaggaagca agcuggggcc      840

aaucaacuga uggcuuucaa ccaucucauu cccggggggu ucccucccac ugccaugccg      900

accuugccaa cguaccagcu gucggagacc ucuuaccagc ccacaucuau uccacaagcu      960

gugucagauc ccagcagcac cguucacaga ccucaaccgc uuccuccaag cacuguacac     1020

caaagcacga uuccuuccaa cccagacagc agcucugccu acugccuccc cagcaccagg     1080

cauggauuuu ccagcuauac agacagcuuu gugccuccgu cggggcccuc caaccccaug     1140

aaccccacca uuggcaaugg ccucucaccu cagguaaugg gacuccugac caaccacggu     1200

gggguaccuc aucagcccca gacugauuac gcgcucuccc cucucaccgg gggucuggaa     1260

ccuaccacca cggugucggc cagcugcagu cagagacuag accauaugaa gagcuuggac     1320

agucugccaa caucucaguc cuacugucca cccaccuaua gcaccacagg cuacaguaug     1380

gacccuguca caggcuacca auaugggcag uauggacaaa guaagccuug gacuuuuuag     1440


<210>  3060
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAX3__Homo_sapiens__CCDS42826.1

<400>  3060
augaccaccc uggccggcgc cgugccccgc augaugcggc cggggcccgg ccagaacuac       60

ccccgcagcg gguucccccu cgaggucucc acgccgcugg gccaggggcg ggugaaccag      120

cugggcggcg uguucaucaa cgggcgcccc cuccccaacc acauccggca caagaucguc      180

gagauggcgc accacggcau ccgccccugc gugaucagcc ggcagcugcg cgugucccac      240

gggugcguca gcaagauccu gugccgguac caggagaccg gcuccauccg cccgggggcc      300

aucggcggca gcaagcccaa gcaggucacc acccccgacg uggagaagaa gaucgaggag      360

uacaagcggg agaaccccgg gauguucucc ugggagaucc gcgacaagcu ccugaaggac      420

gccgugugcg accggaacac ggugccgagc guguccagca ucucccgcau ccugcggagc      480

aaguucggca agggggagga ggaggaggcc gaccucgagc gcaaggaggc cgaggagucc      540

gagaagaagg cgaagcacag caucgacggc auccuguccg agcgggccag cgcgccccag      600

uccgacgagg gcagcgacau cgacuccgag cccgaccugc cccucaagcg caagcagcgg      660

cgcagccgga ccaccuucac cgccgagcag cuggaggagc uggagcgcgc cuucgagcgc      720

acgcacuacc cggacaucua cacccgggag gagcucgccc agcgcgccaa gcugaccgag      780

gcccgggucc aggugugguu cagcaaccgc cgggcccgcu ggcggaagca ggcgggggcc      840

aaccagcuga uggccuucaa ccaccucauc cccggcgggu ucccgcccac cgccaugccc      900

acgcugccca ccuaccagcu guccgagacc agcuaccagc ccaccuccau cccccaggcc      960

gugagcgacc cguccagcac gguccaccgc ccccagcccc ugcccccguc caccgugcac     1020

cagagcacca uccccuccaa ccccgacagc uccagcgcgu acugccuccc guccacccgg     1080

cacggcuuca gcuccuacac ggacagcuuc gugccgcccu ccgggcccag caaccccaug     1140

aaccccacca ucggcaacgg ccuguccccg caggucaugg ggcuccugac caaccacggc     1200

ggggugcccc accagcccca gaccgacuac gcccugagcc cccucacggg cgggcuggag     1260

cccaccacca ccgugagcgc cuccugcagc cagcgccugg accacaugaa gucccucgac     1320

agccugccca cgucccagag cuacugcccg cccaccuacu ccaccaccgg cuacagcaug     1380

gaccccguca cgggcuacca guacgggcag uacggccagu ccaagcccug gaccuucuga     1440


<210>  3061
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAX3__Homo_sapiens__CCDS42826.1

<400>  3061
augaccaccc ucgccggcgc cgucccccgc augaugcgcc ccggccccgg ccagaacuac       60

ccccgcuccg gcuucccccu cgaggucucc accccccucg gccagggccg cgucaaccag      120

cucggcggcg ucuucaucaa cggccgcccc cuccccaacc acauccgcca caagaucguc      180

gagauggccc accacggcau ccgccccugc gucaucuccc gccagcuccg cgucucccac      240

ggcugcgucu ccaagauccu cugccgcuac caggagaccg gcuccauccg ccccggcgcc      300

aucggcggcu ccaagcccaa gcaggucacc acccccgacg ucgagaagaa gaucgaggag      360

uacaagcgcg agaaccccgg cauguucucc ugggagaucc gcgacaagcu ccucaaggac      420

gccgucugcg accgcaacac cguccccucc gucuccucca ucucccgcau ccuccgcucc      480

aaguucggca agggcgagga ggaggaggcc gaccucgagc gcaaggaggc cgaggagucc      540

gagaagaagg ccaagcacuc caucgacggc auccucuccg agcgcgccuc cgccccccag      600

uccgacgagg gcuccgacau cgacuccgag cccgaccucc cccucaagcg caagcagcgc      660

cgcucccgca ccaccuucac cgccgagcag cucgaggagc ucgagcgcgc cuucgagcgc      720

acccacuacc ccgacaucua cacccgcgag gagcucgccc agcgcgccaa gcucaccgag      780

gcccgcgucc aggucugguu cuccaaccgc cgcgcccgcu ggcgcaagca ggccggcgcc      840

aaccagcuca uggccuucaa ccaccucauc cccggcggcu ucccccccac cgccaugccc      900

acccucccca ccuaccagcu cuccgagacc uccuaccagc ccaccuccau cccccaggcc      960

gucuccgacc ccuccuccac cguccaccgc ccccagcccc ucccccccuc caccguccac     1020

caguccacca uccccuccaa ccccgacucc uccuccgccu acugccuccc cuccacccgc     1080

cacggcuucu ccuccuacac cgacuccuuc gucccccccu ccggccccuc caaccccaug     1140

aaccccacca ucggcaacgg ccucuccccc caggucaugg gccuccucac caaccacggc     1200

ggcguccccc accagcccca gaccgacuac gcccucuccc cccucaccgg cggccucgag     1260

cccaccacca ccgucuccgc cuccugcucc cagcgccucg accacaugaa gucccucgac     1320

ucccucccca ccucccaguc cuacugcccc cccaccuacu ccaccaccgg cuacuccaug     1380

gaccccguca ccggcuacca guacggccag uacggccagu ccaagcccug gaccuucuga     1440


<210>  3062
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAX3__Homo_sapiens__CCDS42826.1

<400>  3062
augaccacac uggccggcgc ugugcccaga augaugaggc cugggccagg acagaacuac       60

ccgcggagcg guuucccccu cgaggucucc acuccucuug gccaagggcg cguuaaucag      120

cugggaggcg uguuuaucaa cggucgacca uugcccaauc acauucguca uaagauagua      180

gaaauggcac accaugggau cagaccuugc gugauuucua ggcaguuacg ggucucacac      240

ggaugcguga guaaaauccu gugccgcuau caggagacgg gcagcauuag accaggcgcc      300

aucgggggau ccaagcccaa acaaguuacc acaccugacg uggaaaagaa aauagaggaa      360

uacaagaggg agaacccagg uauguucucu ugggagaucc gggauaagcu acucaaagac      420

gcggucugug aucgcaauac ugugccgucg guaucaagca uuagucgaau ccugagaucc      480

aaguuuggca aaggggaaga ggaagaggcu gaccuugaga ggaaggaagc cgaggaaucu      540

gagaaaaagg caaagcauag cauugaugga auccuguccg aacgggccuc agcuccccag      600

agugacgagg gcagcgauau agacucugag ccugauuugc cacucaaacg uaagcagcgc      660

agauccagga ccacauucac cgcagaacag cuggaggaac uggagcgggc cuuugaacga      720

acucacuauc ccgacauuua cacacgcgag gagcucgcuc aaagagccaa auuaaccgaa      780

gcgaggguuc aggugugguu cucaaaccgg cgcgcaagau ggaggaagca ggccggugcu      840

aaucagcuga uggccuuuaa ccaccuuauc ccugggggau ucccacccac ggcaaugccg      900

acuuugccua ccuaucaacu gagcgagaca aguuaccagc ccacuucuau uccacaggcu      960

gucuccgauc cuagcucgac cgugcaucgu ccccaaccac uacccccuuc uacagugcac     1020

caguccacca ucccaucaaa uccggacagu agcuccgccu auugccuccc cucuacgcgg     1080

cauggcuuua gcucauacac ugauaguuuc gucccuccau ccggccccag caacccuaug     1140

aauccaacaa ucgggaacgg acugucuccc cagguuaugg gucuucugac caaucacggc     1200

ggggugccgc accagccuca aacugacuac gcguugucac cacucacagg aggccuggaa     1260

cccaccacga ccguaagugc cagcuguucc cagcgauuag accauaugaa aucucuggau     1320

ucgcucccua caagccaguc cuauuguccc ccaacuuacu caaccacagg uuauaguaug     1380

gacccuguga cuggguacca guauggccaa uacggacagu cuaagcccug gaccuuuuga     1440


<210>  3063
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAX3__Homo_sapiens__CCDS42826.1

<400>  3063
augaccaccc uggccggcgc cgugcccaga augaugagac ccggccccgg ccagaacuac       60

cccagaagcg gcuucccccu ggaggugagc accccccugg gccagggcag agugaaccag      120

cugggcggcg uguucaucaa cggcagaccc cugcccaacc acaucagaca caagaucgug      180

gagauggccc accacggcau cagacccugc gugaucagca gacagcugag agugagccac      240

ggcugcguga gcaagauccu gugcagauac caggagaccg gcagcaucag acccggcgcc      300

aucggcggca gcaagcccaa gcaggugacc acccccgacg uggagaagaa gaucgaggag      360

uacaagagag agaaccccgg cauguucagc ugggagauca gagacaagcu gcugaaggac      420

gccgugugcg acagaaacac cgugcccagc gugagcagca ucagcagaau ccugagaagc      480

aaguucggca agggcgagga ggaggaggcc gaccuggaga gaaaggaggc cgaggagagc      540

gagaagaagg ccaagcacag caucgacggc auccugagcg agagagccag cgccccccag      600

agcgacgagg gcagcgacau cgacagcgag cccgaccugc cccugaagag aaagcagaga      660

agaagcagaa ccaccuucac cgccgagcag cuggaggagc uggagagagc cuucgagaga      720

acccacuacc ccgacaucua caccagagag gagcuggccc agagagccaa gcugaccgag      780

gccagagugc aggugugguu cagcaacaga agagccagau ggagaaagca ggccggcgcc      840

aaccagcuga uggccuucaa ccaccugauc cccggcggcu ucccccccac cgccaugccc      900

acccugccca ccuaccagcu gagcgagacc agcuaccagc ccaccagcau cccccaggcc      960

gugagcgacc ccagcagcac cgugcacaga ccccagcccc ugccccccag caccgugcac     1020

cagagcacca uccccagcaa ccccgacagc agcagcgccu acugccugcc cagcaccaga     1080

cacggcuuca gcagcuacac cgacagcuuc gugcccccca gcggccccag caaccccaug     1140

aaccccacca ucggcaacgg ccugagcccc caggugaugg gccugcugac caaccacggc     1200

ggcgugcccc accagcccca gaccgacuac gcccugagcc cccugaccgg cggccuggag     1260

cccaccacca ccgugagcgc cagcugcagc cagagacugg accacaugaa gagccuggac     1320

agccugccca ccagccagag cuacugcccc cccaccuaca gcaccaccgg cuacagcaug     1380

gaccccguga ccggcuacca guacggccag uacggccaga gcaagcccug gaccuucuga     1440


<210>  3064
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAX3__Homo_sapiens__CCDS42826.1

<400>  3064
augaccacac uggccggcgc ugugcccaga augaugcggc cugggccggg acagaacuac       60

ccccgcagcg gcuucccucu cgaggucucc acgccccugg ggcaaggaag aguuaaucag      120

cuuggcgggg uguuuaucaa cggacggccu cugcccaauc acauucgcca uaagaucgug      180

gaaauggccc accauggcau uagaccuugc gucaucucuc ggcagcuccg cgugagccac      240

ggcuguguuu ccaaaauucu gugcagauau caggagaccg ggucuauccg gccgggagcg      300

aucggcggga gcaagcccaa acaagugaca accccugacg ucgaaaagaa aauugaggaa      360

uacaagcgcg agaaccccgg aauguucucc ugggagauca gagauaaacu ucugaaggac      420

gcugugugug aucggaauac aguuccuucu gugagcucca uuagccgcau ccucagaucu      480

aaguuuggca aaggggaaga ggaagaggcc gaccuggagc ggaaggaagc cgaggaaucc      540

gagaaaaagg cuaagcauag cauugaugga auccugucug aacgcgccuc cgcuccccag      600

agcgacgagg gcucugauau ugacuccgag ccggaucucc cucugaaaag aaagcagcgg      660

agaagccgca ccacauucac cgccgaacag cuugaggaac uggagcgggc guuugaaaga      720

acgcacuauc ccgacaucua cacccgcgag gagcucgccc aacgggcuaa acugacagaa      780

gccagagucc aggugugguu cuccaaccgc cgggcuagau ggcgcaagca ggccggcgcg      840

aaucagcuua uggccuuuaa ccaccugauc ccugggggau ucccucccac cgcuaugccc      900

acacucccga ccuaucaacu gucugagacg agcuaccagc ccacauccau uccucaggcc      960

gugagcgauc ccucuuccac cguccaucgg ccucaacccc ugccgccuag cacaguucac     1020

cagucuacca uccccagcaa uccugacucc ucuagcgcuu auugccuccc cuccaccaga     1080

cauggcuuua gcucuuacac agauuccuuc gugccuccca gcgggccguc uaacccuaug     1140

aaucccacga uuggaaacgg ccuguccccu caggugaugg ggcuucugac caaucacgga     1200

ggcguccccc accagccgca aacagacuac gcccucagcc cccugaccgg cgggcuugaa     1260

ccuacaacca cgguguccgc cucuuguagc cagcgccugg accauaugaa aucccucgau     1320

ucucugccca caagccaguc cuauugcccu cccaccuaca gcaccacagg auauucuaug     1380

gacccuguua ccggcuacca guaugggcaa uacggacagu ccaagcccug gacauuuuga     1440


<210>  3065
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PAX5__Homo_sapiens__Q02548

<400>  3065

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro His Val Pro 
305                 310                 315                 320 


Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr Leu Thr Gly Met Val 
                325                 330                 335     


Pro Gly Ser Glu Phe Ser Gly Ser Pro Tyr Ser His Pro Gln Tyr Ser 
            340                 345                 350         


Ser Tyr Asn Asp Ser Trp Arg Phe Pro Asn Pro Gly Leu Leu Gly Ser 
        355                 360                 365             


Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala Ala 
    370                 375                 380                 


Ala Thr Ala Tyr Asp Arg His 
385                 390     


<210>  3066
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PAX5__Homo_sapiens__AAA58397

<400>  3066
auggauuuag agaaaaauua uccgacuccu cggaccagca ggacaggaca uggaggagug       60

aaucagcuug gggggguuuu ugugaaugga cggccacucc cggauguagu ccgccagagg      120

auaguggaac uugcucauca aggugucagg cccugcgaca ucuccaggca gcuucggguc      180

agccaugguu gugucagcaa aauucuuggc agguauuaug agacaggaag caucaagccu      240

gggguaauug gaggauccaa accaaagguc gccacaccca aaguggugga aaaaaucgcu      300

gaauauaaac gccaaaaucc caccauguuu gccugggaga ucagggaccg gcugcuggca      360

gagcgggugu gugacaauga caccgugccu agcgucaguu ccaucaacag gaucauccgg      420

acaaaaguac agcagccacc caaccaacca gucccagcuu ccagucacag cauagugucc      480

acuggcuccg ugacgcaggu guccucggug agcacggauu cggccggcuc gucguacucc      540

aucagcggca uccugggcau cacguccccc agcgccgaca ccaacaagcg caagagagac      600

gaagguauuc aggagucucc ggugccgaac ggccacucgc uuccgggcag agacuuccuc      660

cggaagcaga ugcggggaga cuuguucaca cagcagcagc uggaggugcu ggaccgcgug      720

uuugagaggc agcacuacuc agacaucuuc accaccacag agcccaucaa gcccgagcag      780

accacagagu auucagccau ggccucgcug gcuggugggc uggacgacau gaaggccaau      840

cuggccagcc ccaccccugc ugacaucggg agcagugugc caggcccgca guccuacccc      900

auugugacag gccgugacuu ggcgagcacg acccuccccg gguacccucc acacgucccc      960

cccgcuggac agggcagcua cucagcaccg acgcugacag ggauggugcc ugggagugag     1020

uuuuccggga gucccuacag ccacccucag uauuccucgu acaacgacuc cuggagguuc     1080

cccaacccgg ggcugcuugg cucccccuac uauuauagcg cugccgcccg aggagccgcc     1140

ccaccugcag ccgccacugc cuaugaccgu cacuga                               1176


<210>  3067
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PAX5__Homo_sapiens__AAA58397

<400>  3067
auggaccugg agaagaacua ccccacgccc cgcaccagcc ggaccggcca cgggggcgug       60

aaccagcucg ggggcgucuu cgugaacggg cgcccccugc ccgacguggu ccggcagcgc      120

aucguggagc uggcccacca gggcgugcgg cccugcgaca ucucccgcca gcuccggguc      180

agccacggcu gcguguccaa gauccugggg cgcuacuacg agaccggcag caucaagccg      240

ggggugaucg gcggguccaa gcccaagguc gccaccccca agguggugga gaagaucgcg      300

gaguacaagc ggcagaaccc caccauguuc gccugggaga uccgcgaccg gcugcucgcc      360

gagcgcgucu gcgacaacga cacggugccg agcgugucca gcaucaaccg gaucauccgc      420

accaaggucc agcagccgcc caaccagccc gugcccgccu ccagccacuc caucgugagc      480

accggcuccg ucacccaggu gagcuccgug agcacggacu ccgccggcag cuccuacagc      540

aucagcggga uccugggcau caccuccccc agcgcggaca ccaacaagcg gaagcgcgac      600

gaggggaucc aggagucccc cguccccaac ggccacagcc ugccgggccg ggacuuccuc      660

cgcaagcaga ugcgcgggga ccuguucacc cagcagcagc uggaggugcu cgaccgggug      720

uucgagcggc agcacuacuc cgacaucuuc acgaccaccg agcccaucaa gcccgagcag      780

accacggagu acagcgccau ggccucccug gccggcgggc uggacgacau gaaggcgaac      840

cucgccagcc ccaccccggc cgacaucggc uccagcgucc ccgggcccca guccuacccc      900

aucgugaccg gccgcgaccu ggccagcacc acgcugccgg gcuacccgcc ccacgucccg      960

cccgccgggc agggcuccua cagcgcgccc acccucaccg ggauggugcc cggcuccgag     1020

uucagcgggu cccccuacag ccacccccag uacuccagcu acaacgacag cuggcgcuuc     1080

cccaaccccg gccugcuggg cuccccguac uacuacagcg ccgccgcccg cggggccgcg     1140

ccgcccgccg ccgccaccgc cuacgaccgg cacuga                               1176


<210>  3068
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PAX5__Homo_sapiens__AAA58397

<400>  3068
auggaccucg agaagaacua ccccaccccc cgcaccuccc gcaccggcca cggcggcguc       60

aaccagcucg gcggcgucuu cgucaacggc cgcccccucc ccgacgucgu ccgccagcgc      120

aucgucgagc ucgcccacca gggcguccgc cccugcgaca ucucccgcca gcuccgcguc      180

ucccacggcu gcgucuccaa gauccucggc cgcuacuacg agaccggcuc caucaagccc      240

ggcgucaucg gcggcuccaa gcccaagguc gccaccccca aggucgucga gaagaucgcc      300

gaguacaagc gccagaaccc caccauguuc gccugggaga uccgcgaccg ccuccucgcc      360

gagcgcgucu gcgacaacga caccgucccc uccgucuccu ccaucaaccg caucauccgc      420

accaaggucc agcagccccc caaccagccc guccccgccu ccucccacuc caucgucucc      480

accggcuccg ucacccaggu cuccuccguc uccaccgacu ccgccggcuc cuccuacucc      540

aucuccggca uccucggcau caccuccccc uccgccgaca ccaacaagcg caagcgcgac      600

gagggcaucc aggagucccc cguccccaac ggccacuccc uccccggccg cgacuuccuc      660

cgcaagcaga ugcgcggcga ccucuucacc cagcagcagc ucgagguccu cgaccgcguc      720

uucgagcgcc agcacuacuc cgacaucuuc accaccaccg agcccaucaa gcccgagcag      780

accaccgagu acuccgccau ggccucccuc gccggcggcc ucgacgacau gaaggccaac      840

cucgccuccc ccacccccgc cgacaucggc uccuccgucc ccggccccca guccuacccc      900

aucgucaccg gccgcgaccu cgccuccacc acccuccccg gcuacccccc ccacgucccc      960

cccgccggcc agggcuccua cuccgccccc acccucaccg gcaugguccc cggcuccgag     1020

uucuccggcu cccccuacuc ccacccccag uacuccuccu acaacgacuc cuggcgcuuc     1080

cccaaccccg gccuccucgg cucccccuac uacuacuccg ccgccgcccg cggcgccgcc     1140

ccccccgccg ccgccaccgc cuacgaccgc cacuga                               1176


<210>  3069
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PAX5__Homo_sapiens__AAA58397

<400>  3069
auggaccugg agaagaacua ccccaccccu agaacaagca ggacuggcca cgggggagug       60

aaucagcucg guggcgucuu cguuaacggg cggccacuuc cggauguggu acgccaacga      120

aucguggaac uggcccauca gggaguccgu cccugcgaca uuuccagaca guugagggug      180

ucucacggcu guguuucaaa aauauuaggu cgguauuacg agacggggag uaucaagccu      240

ggagugauug gcggcagcaa accaaagguc gcuaccccca aagugguaga aaagaucgca      300

gaguauaagc gccagaaucc uacaauguuu gccugggaaa uuagagauag gcugcuagcg      360

gagcggguuu gcgacaacga uacugugcca uccgucucuu cgaucaaucg cauaauccga      420

accaaagugc aacagccccc uaaccagcca gugccggcuu caagccauag uauugucucc      480

acagggucug uuacccaggu gagcuccgua ucaacugaca gugccggaag cucuuacucc      540

aucucaggua uucucggcau cacaagcccc agugcagaua ccaauaagag aaaaagggac      600

gaggggauac aagaaucucc ugugccaaac ggacacuccc ugcccggccg ggauuuccuu      660

cguaagcaga ugcgcgguga ccuguuuacg cagcagcaau uggagguccu cgauagagug      720

uucgaaaggc agcauuauag cgacauuuuu acuaccacag agccuaucaa accagagcag      780

acuaccgaau acucggccau ggcuucucug gcagggggac uggaugacau gaaggccaau      840

cucgcuuccc ccacaccggc cgacauuggc ucaaguguuc cuggccccca aagcuaucca      900

aucgugaccg ggcgggauuu agcguccacg acucugccug gauauccccc acacgugccc      960

ccugcagguc agggcucuua cagcgcccca acacuuaccg ggaugguccc gggaucagag     1020

uucaguggcu cccccuacag ccacccucag uacucuucau auaacgacag uuggcgauuu     1080

ccaaaucccg guuugcuggg gagcccuuac uauuacuccg cugccgcacg cggcgcugcc     1140

ccacccgcgg ccgcaacugc uuaugauaga cauuga                               1176


<210>  3070
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PAX5__Homo_sapiens__AAA58397

<400>  3070
auggaccugg agaagaacua ccccaccccc agaaccagca gaaccggcca cggcggcgug       60

aaccagcugg gcggcguguu cgugaacggc agaccccugc ccgacguggu gagacagaga      120

aucguggagc uggcccacca gggcgugaga cccugcgaca ucagcagaca gcugagagug      180

agccacggcu gcgugagcaa gauccugggc agauacuacg agaccggcag caucaagccc      240

ggcgugaucg gcggcagcaa gcccaaggug gccaccccca agguggugga gaagaucgcc      300

gaguacaaga gacagaaccc caccauguuc gccugggaga ucagagacag acugcuggcc      360

gagagagugu gcgacaacga caccgugccc agcgugagca gcaucaacag aaucaucaga      420

accaaggugc agcagccccc caaccagccc gugcccgcca gcagccacag caucgugagc      480

accggcagcg ugacccaggu gagcagcgug agcaccgaca gcgccggcag cagcuacagc      540

aucagcggca uccugggcau caccagcccc agcgccgaca ccaacaagag aaagagagac      600

gagggcaucc aggagagccc cgugcccaac ggccacagcc ugcccggcag agacuuccug      660

agaaagcaga ugagaggcga ccuguucacc cagcagcagc uggaggugcu ggacagagug      720

uucgagagac agcacuacag cgacaucuuc accaccaccg agcccaucaa gcccgagcag      780

accaccgagu acagcgccau ggccagccug gccggcggcc uggacgacau gaaggccaac      840

cuggccagcc ccacccccgc cgacaucggc agcagcgugc ccggccccca gagcuacccc      900

aucgugaccg gcagagaccu ggccagcacc acccugcccg gcuacccccc ccacgugccc      960

cccgccggcc agggcagcua cagcgccccc acccugaccg gcauggugcc cggcagcgag     1020

uucagcggca gccccuacag ccacccccag uacagcagcu acaacgacag cuggagauuc     1080

cccaaccccg gccugcuggg cagccccuac uacuacagcg ccgccgccag aggcgccgcc     1140

ccccccgccg ccgccaccgc cuacgacaga cacuga                               1176


<210>  3071
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PAX5__Homo_sapiens__AAA58397

<400>  3071
auggaccugg agaagaacua ccccaccccu agaacaagcc ggacgggcca cgggggagug       60

aaucagcucg gcggggucuu cguuaacgga cgcccgcugc ccgauguggu gagacaacgg      120

aucgucgaac uugcccauca gggcgugcgc ccuugcgaca uuuccagaca gcugcggguu      180

ucucacgggu gugugagcaa aauccucgga cgcuauuacg agaccggcuc cauuaagccc      240

ggcgucaucg ggggaucuaa accuaaggug gcuacaccca aaguugugga aaagauugcc      300

gaguauaaga gacagaaucc uaccauguuu gcgugggaaa uccgggaucg ccugcuugcu      360

gagagagucu gcgacaacga uacagugccg agcguguccu cuaucaaucg gauuauccgc      420

accaaagucc aacagccccc uaaccagccc guuccugcca gcucccauag cauugugucu      480

acaggcuccg ugacccaggu cagcucugug uccacggaca gcgccggguc uuccuacagc      540

aucuccggca uucugggaau caccucuccc agcgcugaua caaauaagag aaaacgggac      600

gaggggauuc aagaaucccc gguuccuaac ggacacagcc uccccggccg cgauuuccug      660

agaaagcaga ugcggggcga ccuguuuacc cagcagcaac ucgaggugcu ggauagaguc      720

uucgaacgcc agcauuauuc ugacaucuuu acaaccacgg agccuaucaa acccgagcag      780

acaaccgaau acuccgccau ggcuagccuu gccgggggac uggaugacau gaaggcgaau      840

cucgccucuc ccacacccgc ugacauuggc agcuccgugc cggggcccca aucuuauccu      900

aucguuaccg gacgggaucu ggccagcacc acacuucccg gcuacccucc ccacgugccg      960

ccugcugggc agggauccua cagcgccccc acgcugaccg gcaugguccc uggcucugag     1020

uucuccggga gccccuauuc ucacccucag uacuccagcu auaacgacuc cuggagauuu     1080

cccaauccgg gacuccuggg cucuccuuac uauuacagcg cggccgcucg cggggccgcu     1140

ccucccgccg ccgcuacagc guaugaucgg cauuga                               1176


<210>  3072
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PD1L1__Homo_sapiens__Q9NZQ7

<400>  3072

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  3073
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PD1L1__Homo_sapiens__AAF25807

<400>  3073
augaggauau uugcugucuu uauauucaug accuacuggc auuugcugaa cgcauuuacu       60

gucacgguuc ccaaggaccu auauguggua gaguauggua gcaauaugac aauugaaugc      120

aaauucccag uagaaaaaca auuagaccug gcugcacuaa uugucuauug ggaaauggag      180

gauaagaaca uuauucaauu ugugcaugga gaggaagacc ugaagguuca gcauaguagc      240

uacagacaga gggcccggcu guugaaggac cagcucuccc ugggaaaugc ugcacuucag      300

aucacagaug ugaaauugca ggaugcaggg guguaccgcu gcaugaucag cuaugguggu      360

gccgacuaca agcgaauuac ugugaaaguc aaugccccau acaacaaaau caaccaaaga      420

auuuugguug uggauccagu caccucugaa caugaacuga caugucaggc ugagggcuac      480

cccaaggccg aagucaucug gacaagcagu gaccaucaag uccugagugg uaagaccacc      540

accaccaauu ccaagagaga ggagaagcuu uucaauguga ccagcacacu gagaaucaac      600

acaacaacua augagauuuu cuacugcacu uuuaggagau uagauccuga ggaaaaccau      660

acagcugaau uggucauccc agaacuaccu cuggcacauc cuccaaauga aaggacucac      720

uugguaauuc ugggagccau cuuauuaugc cuugguguag cacugacauu caucuuccgu      780

uuaagaaaag ggagaaugau ggaugugaaa aaauguggca uccaagauac aaacucaaag      840

aagcaaagug auacacauuu ggaggagacg uaa                                   873


<210>  3074
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PD1L1__Homo_sapiens__AAF25807

<400>  3074
augcgcaucu ucgccguguu caucuucaug accuacuggc accuccucaa cgccuucacc       60

gucacggugc ccaaggaccu guacgugguc gaguacggca gcaacaugac caucgagugc      120

aaguucccgg uggagaagca gcuggaccuc gcggcccuga ucguguacug ggagauggag      180

gacaagaaca ucauccaguu cguccacggg gaggaggacc ugaaggugca gcacuccagc      240

uaccggcagc gcgcccggcu ccugaaggac cagcuguccc ucggcaacgc cgcccugcag      300

aucaccgacg ugaagcugca ggacgcgggg gucuaccgcu gcaugaucag cuacggcggg      360

gccgacuaca agcggaucac cgugaaggug aacgcccccu acaacaagau caaccagcgc      420

auccucgucg uggaccccgu gacguccgag cacgagcuga ccugccaggc cgagggcuac      480

cccaaggcgg aggucaucug gaccagcucc gaccaccagg ugcugagcgg caagaccacg      540

accaccaacu ccaagcggga ggagaagcug uucaacguga ccagcacgcu gcgcaucaac      600

accaccacca acgagaucuu cuacugcacg uuccggcgcc uggacccgga ggagaaccac      660

accgccgagc ucgucauccc cgagcugccc cuggcccacc cgcccaacga gcggacccac      720

cucgugaucc ugggggccau ccugcucugc cugggcgugg cccugaccuu caucuuccgc      780

cuccggaagg ggcgcaugau ggacgucaag aagugcggca uccaggacac gaacuccaag      840

aagcagagcg acacccaccu ggaggagacc uga                                   873


<210>  3075
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PD1L1__Homo_sapiens__AAF25807

<400>  3075
augcgcaucu ucgccgucuu caucuucaug accuacuggc accuccucaa cgccuucacc       60

gucaccgucc ccaaggaccu cuacgucguc gaguacggcu ccaacaugac caucgagugc      120

aaguuccccg ucgagaagca gcucgaccuc gccgcccuca ucgucuacug ggagauggag      180

gacaagaaca ucauccaguu cguccacggc gaggaggacc ucaaggucca gcacuccucc      240

uaccgccagc gcgcccgccu ccucaaggac cagcucuccc ucggcaacgc cgcccuccag      300

aucaccgacg ucaagcucca ggacgccggc gucuaccgcu gcaugaucuc cuacggcggc      360

gccgacuaca agcgcaucac cgucaagguc aacgcccccu acaacaagau caaccagcgc      420

auccucgucg ucgaccccgu caccuccgag cacgagcuca ccugccaggc cgagggcuac      480

cccaaggccg aggucaucug gaccuccucc gaccaccagg uccucuccgg caagaccacc      540

accaccaacu ccaagcgcga ggagaagcuc uucaacguca ccuccacccu ccgcaucaac      600

accaccacca acgagaucuu cuacugcacc uuccgccgcc ucgaccccga ggagaaccac      660

accgccgagc ucgucauccc cgagcucccc cucgcccacc cccccaacga gcgcacccac      720

cucgucaucc ucggcgccau ccuccucugc cucggcgucg cccucaccuu caucuuccgc      780

cuccgcaagg gccgcaugau ggacgucaag aagugcggca uccaggacac caacuccaag      840

aagcaguccg acacccaccu cgaggagacc uga                                   873


<210>  3076
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PD1L1__Homo_sapiens__AAF25807

<400>  3076
augagaaucu ucgccguguu uauuuucaug accuacuggc accuccucaa cgcuuuuaca       60

gucacuguuc ccaaggaccu uuauguggua gaguacggca gcaauaugac gauagaaugc      120

aaauucccug uggagaagca gcuggauuug gcagccuuaa ucgucuauug ggaaauggag      180

gacaaaaaca uuauccaauu ugugcauggg gaagaggauc ugaagguuca gcacuccucu      240

uacaggcagc gggcgcgccu acucaaagac cagcugucac uuggaaaugc ugcccugcaa      300

auuaccgaug ugaaguugca ggacgccggu gucuaucgau guaugaucag uuacggcggg      360

gcagauuaua agcguauaac agugaaagua aacgcuccau acaauaagau caaccagagg      420

auucucguug uggacccggu cacuagcgag caugaacuga ccugccaggc agagggauac      480

cccaaagccg aagugaucug gacauccucu gaucaccaag ugcugucggg caagaccacu      540

acaaccaauu caaaaagaga ggagaagcug uucaacguca cgagcacuuu acggauuaau      600

accacaacua acgaaaucuu uuauuguacc uuccgcagac uggacccuga ggaaaaucau      660

acagcugagc uuguuauacc agaauugccc cuggcccacc cuccaaacga gaggacccac      720

cuagugauuc ucggugcgau ccugcuuugc cuggggguag cauugacguu uauuuuccgg      780

cuccgcaagg gacgaaugau ggaugugaaa aaguguggca uccaggacac uaauaguaaa      840

aagcaguccg auacacaucu ggaggaaacc uga                                   873


<210>  3077
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PD1L1__Homo_sapiens__AAF25807

<400>  3077
augagaaucu ucgccguguu caucuucaug accuacuggc accugcugaa cgccuucacc       60

gugaccgugc ccaaggaccu guacguggug gaguacggca gcaacaugac caucgagugc      120

aaguuccccg uggagaagca gcuggaccug gccgcccuga ucguguacug ggagauggag      180

gacaagaaca ucauccaguu cgugcacggc gaggaggacc ugaaggugca gcacagcagc      240

uacagacaga gagccagacu gcugaaggac cagcugagcc ugggcaacgc cgcccugcag      300

aucaccgacg ugaagcugca ggacgccggc guguacagau gcaugaucag cuacggcggc      360

gccgacuaca agagaaucac cgugaaggug aacgcccccu acaacaagau caaccagaga      420

auccuggugg uggaccccgu gaccagcgag cacgagcuga ccugccaggc cgagggcuac      480

cccaaggccg aggugaucug gaccagcagc gaccaccagg ugcugagcgg caagaccacc      540

accaccaaca gcaagagaga ggagaagcug uucaacguga ccagcacccu gagaaucaac      600

accaccacca acgagaucuu cuacugcacc uucagaagac uggaccccga ggagaaccac      660

accgccgagc uggugauccc cgagcugccc cuggcccacc cccccaacga gagaacccac      720

cuggugaucc ugggcgccau ccugcugugc cugggcgugg cccugaccuu caucuucaga      780

cugagaaagg gcagaaugau ggacgugaag aagugcggca uccaggacac caacagcaag      840

aagcagagcg acacccaccu ggaggagacc uga                                   873


<210>  3078
<211>  873
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PD1L1__Homo_sapiens__AAF25807

<400>  3078
augagaaucu ucgccguguu uauuuucaug accuacuggc accuccucaa cgcuuuuaca       60

gucacgguuc ccaaggaccu guauguggug gaguacggca gcaauaugac caucgaaugc      120

aaauucccug ucgagaagca gcuugaucug gccgcgcuca uuguguauug ggaaauggag      180

gacaaaaaca ucauucaauu uguucauggg gaagaggauc ugaaggugca gcacuccucu      240

uaccggcagc gcgcuagacu ucugaaagac cagcucagcc ugggaaaugc cgcccugcaa      300

aucacagaug ucaagcucca ggacgcuggc guguaucggu guaugaucuc cuacggggga      360

gccgauuaua agcgcauuac cguuaaagug aacgcuccgu acaauaagau caaccagcgg      420

auucuggucg uggaccccgu gacaucugag caugaacuua ccugccaggc cgagggcuac      480

ccuaaagcgg aagucaucug gacaagcucc gaucaccaag uucugucugg gaagaccacg      540

accacaaaua gcaaaagaga ggagaagcug uucaacguga ccuccacacu gcgcauuaau      600

accacgacaa acgaaaucuu uuauuguacc uucagacggc uugaccccga ggaaaaucau      660

acagccgagc uggugauucc ugaacucccc cuggcucacc cuccgaacga gcgcacccac      720

cuggucaucc ucggagccau ccugcuuugc cugggcgugg cucucaccuu uauuuucaga      780

cugcggaagg gccgcaugau ggauguuaaa aaguguggga uccaggacac aaauagcaaa      840

aagcagucug auacgcaucu ugaggaaacc uga                                   873


<210>  3079
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PDCD1__Homo_sapiens__Q15116

<400>  3079

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             






<210>  3080
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PDCD1__Homo_sapiens__AAH74740

<400>  3080
augcagaucc cacaggcgcc cuggccaguc gucugggcgg ugcuacaacu gggcuggcgg       60

ccaggauggu ucuuagacuc cccagacagg cccuggaacc cccccaccuu cuccccagcc      120

cugcucgugg ugaccgaagg ggacaacgcc accuucaccu gcagcuucuc caacacaucg      180

gagagcuucg ugcuaaacug guaccgcaug agccccagca accagacgga caagcuggcc      240

gcuuuccccg aggaccgcag ccagcccggc caggacugcc gcuuccgugu cacacaacug      300

cccaacgggc gugacuucca caugagcgug gucagggccc ggcgcaauga cagcggcacc      360

uaccucugug gggccaucuc ccuggccccc aaggcgcaga ucaaagagag ccugcgggca      420

gagcucaggg ugacagagag aagggcagaa gugcccacag cccaccccag ccccucaccc      480

aggccagccg gccaguucca aacccuggug guuggugucg ugggcggccu gcugggcagc      540

cuggugcugc uagucugggu ccuggccguc aucugcuccc gggccgcacg agggacaaua      600

ggagccaggc gcaccggcca gccccugaag gaggaccccu cagccgugcc uguguucucu      660

guggacuaug gggagcugga uuuccagugg cgagagaaga ccccggagcc ccccgugccc      720

ugugucccug agcagacgga guaugccacc auugucuuuc cuagcggaau gggcaccuca      780

ucccccgccc gcaggggcuc agccgacggc ccucggagug cccagccacu gaggccugag      840

gauggacacu gcucuuggcc ccucuga                                          867


<210>  3081
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PDCD1__Homo_sapiens__AAH74740

<400>  3081
augcagaucc cccaggcccc guggcccgug gucugggccg ugcugcagcu cggcuggcgc       60

cccggguggu uccuggacag ccccgaccgg ccguggaacc cgcccaccuu cucccccgcg      120

cugcucgugg ucaccgaggg cgacaacgcc acguucacgu gcagcuucuc caacaccagc      180

gaguccuucg ugcugaacug guaccgcaug agccccucca accagaccga caagcuggcc      240

gccuuccccg aggaccggag ccagcccggg caggacugcc gcuuccgggu gacccagcuc      300

cccaacggcc gcgacuucca cauguccguc gugcgggccc gccggaacga cagcgggacc      360

uaccugugcg gcgcgaucuc ccuggccccg aaggcccaga ucaaggagag ccuccgcgcc      420

gagcugcggg ugaccgagcg ccgggcggag guccccaccg cccaccccuc ccccagcccg      480

cgccccgccg gccaguucca gacgcuggug gugggggucg ugggcgggcu ccugggcucc      540

cuggugcucc uggucugggu gcuggccgug aucugcagcc gggccgcgcg cgggaccauc      600

ggcgcccggc gcaccggcca gccccucaag gaggaccccu ccgccguccc gguguucagc      660

guggacuacg gggagcugga cuuccagugg cgggagaaga cccccgagcc gcccgucccc      720

ugcgugcccg agcagacgga guacgccacc aucguguucc ccuccggcau ggggaccagc      780

agccccgccc gccggggcuc cgcggacggc ccgcgcagcg cccagccccu gcgccccgag      840

gacgggcacu gcuccuggcc gcucuga                                          867


<210>  3082
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PDCD1__Homo_sapiens__AAH74740

<400>  3082
augcagaucc cccaggcccc cuggcccguc gucugggccg uccuccagcu cggcuggcgc       60

cccggcuggu uccucgacuc ccccgaccgc cccuggaacc cccccaccuu cucccccgcc      120

cuccucgucg ucaccgaggg cgacaacgcc accuucaccu gcuccuucuc caacaccucc      180

gaguccuucg uccucaacug guaccgcaug ucccccucca accagaccga caagcucgcc      240

gccuuccccg aggaccgcuc ccagcccggc caggacugcc gcuuccgcgu cacccagcuc      300

cccaacggcc gcgacuucca cauguccguc guccgcgccc gccgcaacga cuccggcacc      360

uaccucugcg gcgccaucuc ccucgccccc aaggcccaga ucaaggaguc ccuccgcgcc      420

gagcuccgcg ucaccgagcg ccgcgccgag guccccaccg cccaccccuc ccccuccccc      480

cgccccgccg gccaguucca gacccucguc gucggcgucg ucggcggccu ccucggcucc      540

cucguccucc ucgucugggu ccucgccguc aucugcuccc gcgccgcccg cggcaccauc      600

ggcgcccgcc gcaccggcca gccccucaag gaggaccccu ccgccguccc cgucuucucc      660

gucgacuacg gcgagcucga cuuccagugg cgcgagaaga cccccgagcc ccccgucccc      720

ugcguccccg agcagaccga guacgccacc aucgucuucc ccuccggcau gggcaccucc      780

ucccccgccc gccgcggcuc cgccgacggc ccccgcuccg cccagccccu ccgccccgag      840

gacggccacu gcuccuggcc ccucuga                                          867


<210>  3083
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PDCD1__Homo_sapiens__AAH74740

<400>  3083
augcagaucc cccaagcccc uuggccagug gucugggcug uucugcagcu cggcuggaga       60

ccgggguggu uccuugacag ccccgauagg ccuuggaacc cacccaccuu uuccccugca      120

cuguuggugg uaacagaggg agacaaugcc acuuucacgu gcucuuuuuc aaacaccagu      180

gagagcuucg uguuaaauug guaccggaug uccccaucua accagacaga uaagcuggcg      240

gcuuuucccg aagaccgcuc gcagccuggu caagauuguc gauuccgugu cacucagcua      300

ccaaauggca gagacuuuca caugucagug guuagggccc ggcgcaacga uagcgggacc      360

uaucucugcg gagcaauuag ucuggccccg aaagcucaga uaaaggaauc ccuuagagca      420

gagcugaggg ugacagaacg gcgcgccgag guccccaccg cucauccuuc uccaagcccc      480

cgaccugccg gccaguucca aacuuuggug guagguguug ucgggggacu ccugggcucc      540

cuggugcucu uagugugggu gcuggcgguc aucuguucaa gagcagccag gggcacaauu      600

ggggcucggc guaccggaca gccacuuaaa gaggacccca gugccguucc gguguuuagc      660

guagauuacg gugaauugga cuuccagugg cgcgagaaga cgccugaacc cccagugccu      720

ugcguccccg agcagacuga guaugcaacc aucguguuuc caucuggcau ggggacaucc      780

ucacccgcua gaaggggaag cgccgauggc ccucggagug cgcaaccacu gcgaccggaa      840

gacggucacu guucuuggcc ccuauga                                          867


<210>  3084
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PDCD1__Homo_sapiens__AAH74740

<400>  3084
augcagaucc cccaggcccc cuggcccgug gugugggccg ugcugcagcu gggcuggaga       60

cccggcuggu uccuggacag ccccgacaga cccuggaacc cccccaccuu cagccccgcc      120

cugcuggugg ugaccgaggg cgacaacgcc accuucaccu gcagcuucag caacaccagc      180

gagagcuucg ugcugaacug guacagaaug agccccagca accagaccga caagcuggcc      240

gccuuccccg aggacagaag ccagcccggc caggacugca gauucagagu gacccagcug      300

cccaacggca gagacuucca caugagcgug gugagagcca gaagaaacga cagcggcacc      360

uaccugugcg gcgccaucag ccuggccccc aaggcccaga ucaaggagag ccugagagcc      420

gagcugagag ugaccgagag aagagccgag gugcccaccg cccaccccag ccccagcccc      480

agacccgccg gccaguucca gacccuggug gugggcgugg ugggcggccu gcugggcagc      540

cuggugcugc uggugugggu gcuggccgug aucugcagca gagccgccag aggcaccauc      600

ggcgccagaa gaaccggcca gccccugaag gaggacccca gcgccgugcc cguguucagc      660

guggacuacg gcgagcugga cuuccagugg agagagaaga cccccgagcc ccccgugccc      720

ugcgugcccg agcagaccga guacgccacc aucguguucc ccagcggcau gggcaccagc      780

agccccgcca gaagaggcag cgccgacggc cccagaagcg cccagccccu gagacccgag      840

gacggccacu gcagcuggcc ccuguga                                          867


<210>  3085
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PDCD1__Homo_sapiens__AAH74740

<400>  3085
augcagaucc cccaagcccc uuggccggug gucugggcug uucugcagcu cggcuggaga       60

cccggguggu uccuggacag cccugaucgg cccuggaacc cucccaccuu uuccccugcc      120

cuucuggugg ugacagaggg agacaaugcg acguuuaccu gcucuuucag caacacaucc      180

gaaucuuucg uccucaauug guaccgcaug agcccgucca accagaccga uaagcuggcu      240

gccuuucccg aggacagauc ucagccuggc caagauuguc gguuccgcgu gacacagcuu      300

cccaauggga gagacuuuca caugagcguu gugcgggccc gcagaaacga uuccggaacc      360

uaucugugcg gcgcuauuag ccucgccccu aaagcucaga ucaaggaauc ucugcgggcc      420

gagcugcgcg ucacagaaag acgggcggag gugcccaccg cccauccguc cccuagcccc      480

cgcccugcug ggcaguucca aacgcucguu gugggagucg ugggcggccu gcuugggucu      540

cuggugcucc uggucugggu ucuugccgug auuuguucca gagcugcccg gggaaccauc      600

ggcgcgcgca gaacagggca gccccugaaa gaggacccca gcgccgugcc ugucuuuucu      660

guggauuacg gagaacucga cuuccagugg cgggagaaga ccccggaacc cccuguuccc      720

ugcgugccug agcagacaga guaugcuacc auugucuuuc ccuccggcau ggggacgagc      780

uccccggcca gacgcggauc ugcugauggc ccucggagcg cccaaccccu gagaccugaa      840

gacggccacu guuccuggcc ccuguga                                          867


<210>  3086
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PDEF__Homo_sapiens__O95238

<400>  3086

Met Gly Ser Ala Ser Pro Gly Leu Ser Ser Val Ser Pro Ser His Leu 
1               5                   10                  15      


Leu Leu Pro Pro Asp Thr Val Ser Arg Thr Gly Leu Glu Lys Ala Ala 
            20                  25                  30          


Ala Gly Ala Val Gly Leu Glu Arg Arg Asp Trp Ser Pro Ser Pro Pro 
        35                  40                  45              


Ala Thr Pro Glu Gln Gly Leu Ser Ala Phe Tyr Leu Ser Tyr Phe Asp 
    50                  55                  60                  


Met Leu Tyr Pro Glu Asp Ser Ser Trp Ala Ala Lys Ala Pro Gly Ala 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Pro Pro Glu Glu Pro Glu Gln Cys Pro Val Ile 
                85                  90                  95      


Asp Ser Gln Ala Pro Ala Gly Ser Leu Asp Leu Val Pro Gly Gly Leu 
            100                 105                 110         


Thr Leu Glu Glu His Ser Leu Glu Gln Val Gln Ser Met Val Val Gly 
        115                 120                 125             


Glu Val Leu Lys Asp Ile Glu Thr Ala Cys Lys Leu Leu Asn Ile Thr 
    130                 135                 140                 


Ala Asp Pro Met Asp Trp Ser Pro Ser Asn Val Gln Lys Trp Leu Leu 
145                 150                 155                 160 


Trp Thr Glu His Gln Tyr Arg Leu Pro Pro Met Gly Lys Ala Phe Gln 
                165                 170                 175     


Glu Leu Ala Gly Lys Glu Leu Cys Ala Met Ser Glu Glu Gln Phe Arg 
            180                 185                 190         


Gln Arg Ser Pro Leu Gly Gly Asp Val Leu His Ala His Leu Asp Ile 
        195                 200                 205             


Trp Lys Ser Ala Ala Trp Met Lys Glu Arg Thr Ser Pro Gly Ala Ile 
    210                 215                 220                 


His Tyr Cys Ala Ser Thr Ser Glu Glu Ser Trp Thr Asp Ser Glu Val 
225                 230                 235                 240 


Asp Ser Ser Cys Ser Gly Gln Pro Ile His Leu Trp Gln Phe Leu Lys 
                245                 250                 255     


Glu Leu Leu Leu Lys Pro His Ser Tyr Gly Arg Phe Ile Arg Trp Leu 
            260                 265                 270         


Asn Lys Glu Lys Gly Ile Phe Lys Ile Glu Asp Ser Ala Gln Val Ala 
        275                 280                 285             


Arg Leu Trp Gly Ile Arg Lys Asn Arg Pro Ala Met Asn Tyr Asp Lys 
    290                 295                 300                 


Leu Ser Arg Ser Ile Arg Gln Tyr Tyr Lys Lys Gly Ile Ile Arg Lys 
305                 310                 315                 320 


Pro Asp Ile Ser Gln Arg Leu Val Tyr Gln Phe Val His Pro Ile 
                325                 330                 335 


<210>  3087
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PDEF__Homo_sapiens__AAC95296

<400>  3087
augggcagcg ccagcccggg ucugagcagc guauccccca gccaccuccu gcugcccccc       60

gacacggugu cgcggacagg cuuggagaag gcggcagcgg gggcaguggg ucucgagaga      120

cgggacugga gucccagucc acccgccacg cccgagcagg gccuguccgc cuucuaccuc      180

uccuacuuug acaugcugua cccugaggac agcagcuggg cagccaaggc cccuggggcc      240

agcagucggg aggagccacc ugaggagccu gagcagugcc cggucauuga cagccaagcc      300

ccagcgggca gccuggacuu ggugcccggc gggcugaccu uggaggagca cucgcuggag      360

caggugcagu ccaugguggu gggcgaagug cucaaggaca ucgagacggc cugcaagcug      420

cucaacauca ccgcagaucc cauggacugg agccccagca augugcagaa guggcuccug      480

uggacagagc accaauaccg gcugcccccc augggcaagg ccuuccagga gcuggcgggc      540

aaggagcugu gcgccauguc ggaggagcag uuccgccagc gcucgccccu ggguggggau      600

gugcugcacg cccaccugga caucuggaag ucagcggccu ggaugaaaga gcggacuuca      660

ccuggggcga uucacuacug ugccucgacc agugaggaga gcuggaccga cagcgaggug      720

gacucaucau gcuccgggca gcccauccac cuguggcagu uccucaagga guugcuacuc      780

aagccccaca gcuauggccg cuucauuagg uggcucaaca aggagaaggg caucuucaaa      840

auugaggacu cagcccaggu ggcccggcug uggggcaucc gcaagaaccg ucccgccaug      900

aacuacgaca agcugagccg cuccauccgc caguauuaca agaagggcau cauccggaag      960

ccagacaucu cccagcgccu cgucuaccag uucgugcacc ccaucuga                  1008


<210>  3088
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PDEF__Homo_sapiens__AAC95296

<400>  3088
augggcagcg ccucccccgg gcugagcucc gugagcccgu cccaccuccu gcugccgccc       60

gacaccguca gccgcaccgg ccucgagaag gccgcggccg gggccguggg ccuggagcgg      120

cgcgacuggu cccccagccc gcccgccacg cccgagcagg ggcuguccgc cuucuaccuc      180

agcuacuucg acaugcugua ccccgaggac uccagcuggg cggccaaggc ccccggcgcc      240

uccagccggg aggagccgcc cgaggagccc gagcagugcc ccgugaucga cucccaggcg      300

cccgccggca gccuggaccu cguccccggg ggccugaccc uggaggagca cucccucgag      360

cagguccaga gcaugguggu gggggaggug cugaaggaca ucgagaccgc cugcaagcug      420

cucaacauca ccgccgaccc cauggacugg uccccgagca acgugcagaa guggcugcug      480

uggacggagc accaguaccg ccucccgccc augggcaagg ccuuccagga gcuggcgggg      540

aaggagcugu gcgccaugag cgaggagcag uuccggcagc gcagcccccu cggcggcgac      600

guccugcacg cccaccugga caucuggaag uccgccgccu ggaugaagga gcggaccucc      660

cccggggcga uccacuacug cgccagcacc uccgaggaga gcuggaccga cuccgaggug      720

gacagcuccu gcagcggcca gcccauccac cucuggcagu uccugaagga gcugcuccug      780

aagccccacu ccuacgggcg cuucauccgg uggcugaaca aggagaaggg caucuucaag      840

aucgaggaca gcgcccaggu ggcccgccuc uggggcaucc ggaagaaccg ccccgccaug      900

aacuacgaca agcugucccg gagcauccgc caguacuaca agaaggggau cauccggaag      960

ccggacaucu cccagcgccu ggucuaccag uucgugcacc ccaucuga                  1008


<210>  3089
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PDEF__Homo_sapiens__AAC95296

<400>  3089
augggcuccg ccucccccgg ccucuccucc gucucccccu cccaccuccu ccuccccccc       60

gacaccgucu cccgcaccgg ccucgagaag gccgccgccg gcgccgucgg ccucgagcgc      120

cgcgacuggu cccccucccc ccccgccacc cccgagcagg gccucuccgc cuucuaccuc      180

uccuacuucg acaugcucua ccccgaggac uccuccuggg ccgccaaggc ccccggcgcc      240

uccucccgcg aggagccccc cgaggagccc gagcagugcc ccgucaucga cucccaggcc      300

cccgccggcu cccucgaccu cguccccggc ggccucaccc ucgaggagca cucccucgag      360

cagguccagu ccauggucgu cggcgagguc cucaaggaca ucgagaccgc cugcaagcuc      420

cucaacauca ccgccgaccc cauggacugg ucccccucca acguccagaa guggcuccuc      480

uggaccgagc accaguaccg ccuccccccc augggcaagg ccuuccagga gcucgccggc      540

aaggagcucu gcgccauguc cgaggagcag uuccgccagc gcuccccccu cggcggcgac      600

guccuccacg cccaccucga caucuggaag uccgccgccu ggaugaagga gcgcaccucc      660

cccggcgcca uccacuacug cgccuccacc uccgaggagu ccuggaccga cuccgagguc      720

gacuccuccu gcuccggcca gcccauccac cucuggcagu uccucaagga gcuccuccuc      780

aagccccacu ccuacggccg cuucauccgc uggcucaaca aggagaaggg caucuucaag      840

aucgaggacu ccgcccaggu cgcccgccuc uggggcaucc gcaagaaccg ccccgccaug      900

aacuacgaca agcucucccg cuccauccgc caguacuaca agaagggcau cauccgcaag      960

cccgacaucu cccagcgccu cgucuaccag uucguccacc ccaucuga                  1008


<210>  3090
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PDEF__Homo_sapiens__AAC95296

<400>  3090
augggcagcg ccucccccgg gcugucuuca gugaguccua gccaccuccu ucugccaccg       60

gacaccgucu ccagaacagg auuggagaag gcugcagccg gugcgguugg cuuagaaagg      120

cgggauuggu cucccucgcc uccagcuacu cccgagcagg ggcugucagc cuucuaccua      180

agcuauuuug acaugcucua cccugaagau aguuccuggg cagccaaagc uccaggagca      240

ucuagccgcg aggaaccccc ugaggagcca gaacaaugcc cggugaucga cucccaggcc      300

cccgcuggcu cacuggaucu uguaccuggu gggcugacgu uggaggaaca uagucucgaa      360

caggugcaga gcauggucgu gggagagguu cugaaggaca uugaaaccgc cuguaaacug      420

cucaacauaa cagcggaucc aauggacugg ucucccucca augugcaaaa gugguuacug      480

uggacugagc accaguaucg acuuccucca augggcaaag cauuccagga auuggccggc      540

aaggagcugu gcgcuauguc agaggagcag uuucgucaaa gaagcccccu agggggagau      600

guccuccaug cccaccugga caucuggaag agugcagcuu ggaugaaaga gaggaccucu      660

ccgggugcca uucauuacug ugcguccaca agcgaagagu cguggaccga uucugaagug      720

gacuccucau gcaguggcca gccuauccac cuuuggcagu uccugaagga guugcuccug      780

aaaccccaca gcuaugggcg guuuauucgc ugguuaaaca aggaaaaagg aaucuucaag      840

auagaggauu ccgcccaggu agcaagacug uggggcauca ggaagaaucg gccagcuaug      900

aacuacgaca aacucucucg cagcauucga caauauuaca agaaagguau cauuagaaag      960

ccugacaucu cacagaggcu uguuuaccag uuugugcauc ccauauga                  1008


<210>  3091
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PDEF__Homo_sapiens__AAC95296

<400>  3091
augggcagcg ccagccccgg ccugagcagc gugagcccca gccaccugcu gcugcccccc       60

gacaccguga gcagaaccgg ccuggagaag gccgccgccg gcgccguggg ccuggagaga      120

agagacugga gccccagccc ccccgccacc cccgagcagg gccugagcgc cuucuaccug      180

agcuacuucg acaugcugua ccccgaggac agcagcuggg ccgccaaggc ccccggcgcc      240

agcagcagag aggagccccc cgaggagccc gagcagugcc ccgugaucga cagccaggcc      300

cccgccggca gccuggaccu ggugcccggc ggccugaccc uggaggagca cagccuggag      360

caggugcaga gcaugguggu gggcgaggug cugaaggaca ucgagaccgc cugcaagcug      420

cugaacauca ccgccgaccc cauggacugg agccccagca acgugcagaa guggcugcug      480

uggaccgagc accaguacag acugcccccc augggcaagg ccuuccagga gcuggccggc      540

aaggagcugu gcgccaugag cgaggagcag uucagacaga gaagcccccu gggcggcgac      600

gugcugcacg cccaccugga caucuggaag agcgccgccu ggaugaagga gagaaccagc      660

cccggcgcca uccacuacug cgccagcacc agcgaggaga gcuggaccga cagcgaggug      720

gacagcagcu gcagcggcca gcccauccac cuguggcagu uccugaagga gcugcugcug      780

aagccccaca gcuacggcag auucaucaga uggcugaaca aggagaaggg caucuucaag      840

aucgaggaca gcgcccaggu ggccagacug uggggcauca gaaagaacag acccgccaug      900

aacuacgaca agcugagcag aagcaucaga caguacuaca agaagggcau caucagaaag      960

cccgacauca gccagagacu gguguaccag uucgugcacc ccaucuga                  1008


<210>  3092
<211>  1008
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PDEF__Homo_sapiens__AAC95296

<400>  3092
augggcagcg ccucccccgg gcugucuagc guguccccuu cucaccuccu gcuuccgccc       60

gacaccguca gcagaacagg acuggagaag gcugccgcgg gcgcuguugg gcucgaacgg      120

cgcgauuggu ccccuucucc cccugccacg cccgagcagg gacugagcgc cuucuaccuu      180

uccuauuuug acaugcugua cccugaagau agcucuuggg cugccaaagc uccgggcgcc      240

uccagcagag aggaaccccc ugaggagccc gaacaaugcc cugugaucga cucucaggcg      300

cccgccgggu cccucgaucu ggugccggga ggccugaccc ucgaggaaca uagccuggag      360

cagguccagu cuaugguggu uggcgaggug cuuaaggaca uugaaacagc uuguaaacug      420

cucaacauca ccgccgaucc uauggacugg ucccccagca auguccaaaa guggcugcuu      480

uggacagagc accaguaucg gcugccuccc auggggaagg cuuuccagga acucgccgga      540

aaggagcugu gcgcgauguc cgaggaacag uuucgccaaa gaucuccccu gggcggggau      600

gugcuccaug cccaccugga cauuuggaaa agcgcugccu ggaugaaaga gcggaccucc      660

ccuggagcua uccauuacug ugccagcaca ucugaagagu ccuggaccga uagcgaaguu      720

gacucuagcu gcuccggcca gccgauucac cuuuggcagu uccugaagga gcuccugcuu      780

aaaccccacu cuuaugggcg cuuuaucaga uggcugaaca aggaaaaagg aaucuucaag      840

auugaggaua gcgcccaggu ggcucggcuc uggggcaucc gcaagaauag accugcgaug      900

aacuacgaca aacugucccg gagcauucgc caauauuaca agaaaggcau cauuagaaag      960

cccgacaucu cucagcggcu ggucuaccag uuugugcauc cuauuuga                  1008


<210>  3093
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PECA1__Homo_sapiens__P16284

<400>  3093

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  3094
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PECA1__Homo_sapiens__AAA36429

<400>  3094
augcagccga ggugggccca aggggccacg auguggcuug gaguccugcu gacccuucug       60

cucuguucaa gccuugaggg ucaagaaaac ucuuucacaa ucaacagugu ugacaugaag      120

agccugccgg acuggacggu gcaaaauggg aagaaccuga cccugcagug cuucgcggau      180

gucagcacca ccucucacgu caagccucag caccagaugc uguucuauaa ggaugacgug      240

cuguuuuaca acaucuccuc caugaagagc acagagaguu auuuuauucc ugaaguccgg      300

aucuaugacu cagggacaua uaaauguacu gugauuguga acaacaaaga gaaaaccacu      360

gcagaguacc agcuguuggu ggaaggagug cccaguccca gggugacacu ggacaagaaa      420

gaggccaucc aaggugggau cgugaggguc aacuguucug ucccagagga aaaggcccca      480

auacacuuca caauugaaaa acuugaacua aaugaaaaaa uggucaagcu gaaaagagag      540

aagaauucuc gagaccagaa uuuugugaua cuggaauucc ccguugagga acaggaccgc      600

guuuuauccu uccgauguca agcuaggauc auuucuggga uccauaugca gaccucagaa      660

ucuaccaaga gugaacuggu caccgugacg gaauccuucu cuacacccaa guuccacauc      720

agccccaccg gaaugaucau ggaaggagcu cagcuccaca uuaagugcac cauucaagug      780

acucaccugg cccaggaguu uccagaaauc auaauucaga aggacaaggc gauuguggcc      840

cacaacagac auggcaacaa ggcuguguac ucagucaugg ccauggugga gcacaguggc      900

aacuacacgu gcaaagugga guccagccgc auauccaagg ucagcagcau cguggucaac      960

auaacagaac uauuuuccaa gcccgaacug gaaucuuccu ucacacaucu ggaccaaggu     1020

gaaagacuga accuguccug cuccauccca ggagcaccuc cagccaacuu caccauccag     1080

aaggaagaua cgauuguguc acagacucaa gauuucacca agauagccuc aaagucggac     1140

agugggacgu auaucugcac ugcagguauu gacaaagugg ucaagaaaag caacacaguc     1200

cagauagucg uaugugaaau gcucucccag cccaggauuu cuuaugaugc ccaguuugag     1260

gucauaaaag gacagaccau cgaaguccgu ugcgaaucga ucaguggaac uuugccuauu     1320

ucuuaccaac uuuuaaaaac aaguaaaguu uuggagaaua guaccaagaa cucaaaugau     1380

ccugcgguau ucaaagacaa ccccacugaa gacgucgaau accagugugu ugcagauaau     1440

ugccauuccc augccaaaau guuaagugag guucugaggg ugaaggugau agccccggug     1500

gaugaggucc agauuucuau ccugucaagu aagguggugg agucuggaga ggacauugug     1560

cugcaaugug cugugaauga aggaucuggu cccaucaccu auaaguuuua cagagaaaaa     1620

gagggcaaac ccuucuauca aaugaccuca aaugccaccc aggcauuuug gaccaagcag     1680

aaggcuagca aggaacagga gggagaguau uacugcacag ccuucaacag agccaaccac     1740

gccuccagug uccccagaag caaaauacug acagucagag ucauucuugc cccauggaag     1800

aaaggacuua uugcaguggu uaucaucgga gugaucauug cucucuugau cauugcggcc     1860

aaauguuauu uucugaggaa agccaaggcc aagcagaugc caguggaaau guccaggcca     1920

gcaguaccac uucugaacuc caacaacgag aaaaugucag aucccaauau ggaagcuaac     1980

agucauuacg gucacaauga cgaugucaga aaccaugcaa ugaaaccaau aaaugauaau     2040

aaagagccuc ugaacucaga cgugcaguac acggaaguuc aaguguccuc agcugagucu     2100

cacaaagauc uaggaaagaa ggacacagag acaguguaca gugaaguccg gaaagcuguc     2160

ccugaugccg uggaaagcag auacucuaga acggaaggcu cccuugaugg aacuuag        2217


<210>  3095
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PECA1__Homo_sapiens__AAA36429

<400>  3095
augcagcccc gcugggccca gggcgccacc auguggcugg gggugcuccu gacccugcuc       60

cugugcagcu cccuggaggg ccaggagaac agcuucacga ucaacuccgu cgacaugaag      120

ucccucccgg acuggaccgu gcagaacggg aagaaccuga cccugcagug cuucgcggac      180

gugagcacca cgagccacgu caagccccag caccagaugc uguucuacaa ggacgacguc      240

cucuucuaca acaucuccag caugaagucc accgagagcu acuucauccc cgaggugcgg      300

aucuacgacu ccggcaccua caagugcacc gugaucguga acaacaagga gaagacgacc      360

gccgaguacc agcugcucgu ggaggggguc cccagcccgc gcgugacccu ggacaagaag      420

gaggccaucc agggcggcau cgugcggguc aacugcuccg ugcccgagga gaaggccccc      480

auccacuuca ccaucgagaa gcuggagcuc aacgagaaga uggugaagcu gaagcgcgag      540

aagaacagcc gggaccagaa cuucgucauc cuggaguucc ccguggagga gcaggaccgc      600

gugcucuccu uccggugcca ggcccgcauc aucagcggga uccacaugca gacguccgag      660

agcaccaagu ccgagcuggu caccgugacc gagagcuuca gcacgccgaa guuccacauc      720

ucccccaccg gcaugaucau ggagggggcg cagcugcaca ucaagugcac cauccaggug      780

acccaccucg cccaggaguu ccccgagauc aucauccaga aggacaaggc caucgucgcc      840

cacaaccggc acggcaacaa ggcgguguac agcgugaugg ccauggucga gcacuccggg      900

aacuacacgu gcaaggugga gagcucccgc aucagcaagg ucuccagcau cguggugaac      960

aucaccgagc uguucuccaa gcccgagcug gagagcuccu ucacccaccu cgaccagggc     1020

gagcggcuga accugagcug cuccaucccg ggcgccccgc ccgccaacuu caccauccag     1080

aaggaggaca cgaucgucag ccagacccag gacuucacca agaucgccuc caagagcgac     1140

uccgggaccu acaucugcac ggcgggcauc gacaaggugg ugaagaaguc caacaccguc     1200

cagaucgugg ugugcgagau gcucagccag ccccgcauca gcuacgacgc ccaguucgag     1260

gucaucaagg ggcagaccau cgaggugcgg ugcgagagca ucuccggcac ccugcccauc     1320

agcuaccagc ugcucaagac guccaaggug cuggagaaca gcaccaagaa cuccaacgac     1380

cccgccgucu ucaaggacaa ccccaccgag gacguggagu accagugcgu ggccgacaac     1440

ugccacagcc acgccaagau gcuguccgag guccuccgcg ugaaggugau cgcgcccguc     1500

gacgaggugc agaucagcau ccuguccagc aagguggucg aguccggcga ggacaucgug     1560

cugcagugcg ccgugaacga ggggagcggc ccgaucaccu acaaguucua ccgggagaag     1620

gaggggaagc ccuucuacca gaugacgucc aacgccaccc aggccuucug gaccaagcag     1680

aaggccagca aggagcagga gggcgaguac uacugcaccg cguucaaccg cgccaaccac     1740

gccuccagcg ucccccgguc caagauccuc accgugcgcg ugauccuggc ccccuggaag     1800

aaggggcuga ucgccgucgu gaucaucggc gugaucaucg cgcuccugau caucgccgcc     1860

aagugcuacu uccugcggaa ggccaaggcg aagcagaugc cggucgagau gagccgcccc     1920

gccgugcccc uccugaacag caacaacgag aagauguccg accccaacau ggaggccaac     1980

agccacuacg gccacaacga cgacgugcgg aaccacgcca ugaagccgau caacgacaac     2040

aaggagcccc ugaacuccga cguccaguac acggaggucc aggugagcuc cgccgagagc     2100

cacaaggacc ucgggaagaa ggacaccgag accguguacu ccgaggugcg caaggcggug     2160

cccgacgccg ucgagagccg cuacucccgg accgagggca gccuggacgg gacguga        2217


<210>  3096
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PECA1__Homo_sapiens__AAA36429

<400>  3096
augcagcccc gcugggccca gggcgccacc auguggcucg gcguccuccu cacccuccuc       60

cucugcuccu cccucgaggg ccaggagaac uccuucacca ucaacuccgu cgacaugaag      120

ucccuccccg acuggaccgu ccagaacggc aagaaccuca cccuccagug cuucgccgac      180

gucuccacca ccucccacgu caagccccag caccagaugc ucuucuacaa ggacgacguc      240

cucuucuaca acaucuccuc caugaagucc accgaguccu acuucauccc cgagguccgc      300

aucuacgacu ccggcaccua caagugcacc gucaucguca acaacaagga gaagaccacc      360

gccgaguacc agcuccucgu cgagggcguc cccucccccc gcgucacccu cgacaagaag      420

gaggccaucc agggcggcau cguccgcguc aacugcuccg uccccgagga gaaggccccc      480

auccacuuca ccaucgagaa gcucgagcuc aacgagaaga uggucaagcu caagcgcgag      540

aagaacuccc gcgaccagaa cuucgucauc cucgaguucc ccgucgagga gcaggaccgc      600

guccucuccu uccgcugcca ggcccgcauc aucuccggca uccacaugca gaccuccgag      660

uccaccaagu ccgagcucgu caccgucacc gaguccuucu ccacccccaa guuccacauc      720

ucccccaccg gcaugaucau ggagggcgcc cagcuccaca ucaagugcac cauccagguc      780

acccaccucg cccaggaguu ccccgagauc aucauccaga aggacaaggc caucgucgcc      840

cacaaccgcc acggcaacaa ggccgucuac uccgucaugg ccauggucga gcacuccggc      900

aacuacaccu gcaaggucga guccucccgc aucuccaagg ucuccuccau cgucgucaac      960

aucaccgagc ucuucuccaa gcccgagcuc gaguccuccu ucacccaccu cgaccagggc     1020

gagcgccuca accucuccug cuccaucccc ggcgcccccc ccgccaacuu caccauccag     1080

aaggaggaca ccaucgucuc ccagacccag gacuucacca agaucgccuc caaguccgac     1140

uccggcaccu acaucugcac cgccggcauc gacaaggucg ucaagaaguc caacaccguc     1200

cagaucgucg ucugcgagau gcucucccag ccccgcaucu ccuacgacgc ccaguucgag     1260

gucaucaagg gccagaccau cgagguccgc ugcgagucca ucuccggcac ccuccccauc     1320

uccuaccagc uccucaagac cuccaagguc cucgagaacu ccaccaagaa cuccaacgac     1380

cccgccgucu ucaaggacaa ccccaccgag gacgucgagu accagugcgu cgccgacaac     1440

ugccacuccc acgccaagau gcucuccgag guccuccgcg ucaaggucau cgcccccguc     1500

gacgaggucc agaucuccau ccucuccucc aaggucgucg aguccggcga ggacaucguc     1560

cuccagugcg ccgucaacga gggcuccggc cccaucaccu acaaguucua ccgcgagaag     1620

gagggcaagc ccuucuacca gaugaccucc aacgccaccc aggccuucug gaccaagcag     1680

aaggccucca aggagcagga gggcgaguac uacugcaccg ccuucaaccg cgccaaccac     1740

gccuccuccg ucccccgcuc caagauccuc accguccgcg ucauccucgc ccccuggaag     1800

aagggccuca ucgccgucgu caucaucggc gucaucaucg cccuccucau caucgccgcc     1860

aagugcuacu uccuccgcaa ggccaaggcc aagcagaugc ccgucgagau gucccgcccc     1920

gccguccccc uccucaacuc caacaacgag aagauguccg accccaacau ggaggccaac     1980

ucccacuacg gccacaacga cgacguccgc aaccacgcca ugaagcccau caacgacaac     2040

aaggagcccc ucaacuccga cguccaguac accgaggucc aggucuccuc cgccgagucc     2100

cacaaggacc ucggcaagaa ggacaccgag accgucuacu ccgagguccg caaggccguc     2160

cccgacgccg ucgagucccg cuacucccgc accgagggcu cccucgacgg caccuga        2217


<210>  3097
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PECA1__Homo_sapiens__AAA36429

<400>  3097
augcagccca gaugggccca aggcgcuacc auguggcugg gggugcuccu uacacuguug       60

uuaugcagcu cccuggaggg acaggaaaac ucuuucacua ucaauucagu cgacaugaag      120

agucuaccug auuggacggu ucagaacggu aaaaaucuca cccugcagug uuuugcagac      180

gugagcacaa cuucccacgu aaagccacaa caucagaugc uuuucuacaa agaugacgug      240

cuguuuuaua acauuucuuc gaugaaguca accgagagcu acuucauacc ggaagucagg      300

aucuaugaua guggcacaua caaaugcacc gugauuguua auaacaagga gaagacuaca      360

gccgaauauc aguugcucgu ggaggggguc cccuccccuc gggugacccu ggacaaaaag      420

gaggcgaucc agggaggcau uguacgcguu aauuguucug ugccagaaga gaaagcuccc      480

auccacuuua cgauagaaaa gcuggagcuc aacgagaaaa uggucaaguu aaagcgagaa      540

aagaauagcc gugaucaaaa cuucgugauc cuggaguuuc cuguggagga gcaggacaga      600

guccuuuccu ucaggugcca ggcccggauu aucucaggua uucauaugca gaccagugaa      660

agcacuaagu cugaguuggu uacagugacu gaguccuuuu caaccccaaa auuccacauc      720

agccccacag ggaugauaau ggaaggagca caacugcaua uuaaguguac cauccaggua      780

acgcaccuag cccaggaguu uccugaaauu aucauccaaa aagauaaggc uauuguggca      840

cacaaucgcc auggcaacaa agccgucuac agugugaugg cuaugguuga gcacucuggc      900

aauuauacuu gcaaggugga auccagcaga auaucgaagg ucucuuccau cgugguaaac      960

auuacagaac ucuucucaaa accagagcug gaaaguagcu uuacccaucu ugaccagggg     1020

gagaggcuga auuuguccug uucuaucccg ggagcucccc cugcgaacuu cacuauacag     1080

aaggaagaua caauuguuag ccagacccaa gacuucacga aaaucgcauc aaagagugau     1140

uccgguaccu acaucugcac agccggcauu gacaaagugg ucaaaaagag caacacugug     1200

cagaucgucg ugugugagau gcucucucag ccacggauuu cauacgacgc ucaguuugaa     1260

guuauaaaag ggcaaaccau cgaggugcgc ugcgagagua uuagcggaac acugcccauc     1320

uccuaucagu uacugaagac uucuaaagua cucgaaaauu cgaccaagaa cagcaaugau     1380

ccugccgucu ucaaagacaa cccaacagag gauguggaau accagugugu ugcagacaau     1440

ugccacuccc acgcuaagau gcuuucagag gugcugcgag ucaaggugau cgcccccgua     1500

gaugaggugc agauuaguau auugucuagc aaaguugucg aauccggcga ggacaucgug     1560

cuacaaugcg cggugaacga agguucaggg ccgauuaccu auaaguuuua cagagagaaa     1620

gaaggaaagc cuuucuauca gaugacuagc aaugccacgc aggcauuuug gacaaaacag     1680

aaggcuucua aggagcaaga gggcgaauac uauuguaccg ccuucaacag ggcuaaucau     1740

gccuccagug ucccccggag caaaauccug acuguucgug ugauucucgc accauggaag     1800

aaaggccuga ucgccguggu aauaaucggg gucauuaucg cccuucugau uaucgcggca     1860

aagugcuacu uuuugcgcaa agccaaggcu aaacagaugc cuguggagau gucuagaccc     1920

gccguuccac uccugaacuc caauaacgaa aagaugucag aucccaauau ggaggcaaac     1980

agucacuacg gacauaauga cgaugugagg aaccacgcca ugaagccuau aaacgacaau     2040

aaagaaccau uaaacagcga uguccaguau accgaggugc aaguuucguc cgcugagucu     2100

cauaaggacc uggguaaaaa ggacacagaa accguguaca gcgagguacg gaaagccguc     2160

ccggaugcag uggaaucacg auauagucgc acugagggcu cccuagacgg gacauga        2217


<210>  3098
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PECA1__Homo_sapiens__AAA36429

<400>  3098
augcagccca gaugggccca gggcgccacc auguggcugg gcgugcugcu gacccugcug       60

cugugcagca gccuggaggg ccaggagaac agcuucacca ucaacagcgu ggacaugaag      120

agccugcccg acuggaccgu gcagaacggc aagaaccuga cccugcagug cuucgccgac      180

gugagcacca ccagccacgu gaagccccag caccagaugc uguucuacaa ggacgacgug      240

cuguucuaca acaucagcag caugaagagc accgagagcu acuucauccc cgaggugaga      300

aucuacgaca gcggcaccua caagugcacc gugaucguga acaacaagga gaagaccacc      360

gccgaguacc agcugcuggu ggagggcgug cccagcccca gagugacccu ggacaagaag      420

gaggccaucc agggcggcau cgugagagug aacugcagcg ugcccgagga gaaggccccc      480

auccacuuca ccaucgagaa gcuggagcug aacgagaaga uggugaagcu gaagagagag      540

aagaacagca gagaccagaa cuucgugauc cuggaguucc ccguggagga gcaggacaga      600

gugcugagcu ucagaugcca ggccagaauc aucagcggca uccacaugca gaccagcgag      660

agcaccaaga gcgagcuggu gaccgugacc gagagcuuca gcacccccaa guuccacauc      720

agccccaccg gcaugaucau ggagggcgcc cagcugcaca ucaagugcac cauccaggug      780

acccaccugg cccaggaguu ccccgagauc aucauccaga aggacaaggc caucguggcc      840

cacaacagac acggcaacaa ggccguguac agcgugaugg ccauggugga gcacagcggc      900

aacuacaccu gcaaggugga gagcagcaga aucagcaagg ugagcagcau cguggugaac      960

aucaccgagc uguucagcaa gcccgagcug gagagcagcu ucacccaccu ggaccagggc     1020

gagagacuga accugagcug cagcaucccc ggcgcccccc ccgccaacuu caccauccag     1080

aaggaggaca ccaucgugag ccagacccag gacuucacca agaucgccag caagagcgac     1140

agcggcaccu acaucugcac cgccggcauc gacaaggugg ugaagaagag caacaccgug     1200

cagaucgugg ugugcgagau gcugagccag cccagaauca gcuacgacgc ccaguucgag     1260

gugaucaagg gccagaccau cgaggugaga ugcgagagca ucagcggcac ccugcccauc     1320

agcuaccagc ugcugaagac cagcaaggug cuggagaaca gcaccaagaa cagcaacgac     1380

cccgccgugu ucaaggacaa ccccaccgag gacguggagu accagugcgu ggccgacaac     1440

ugccacagcc acgccaagau gcugagcgag gugcugagag ugaaggugau cgcccccgug     1500

gacgaggugc agaucagcau ccugagcagc aagguggugg agagcggcga ggacaucgug     1560

cugcagugcg ccgugaacga gggcagcggc cccaucaccu acaaguucua cagagagaag     1620

gagggcaagc ccuucuacca gaugaccagc aacgccaccc aggccuucug gaccaagcag     1680

aaggccagca aggagcagga gggcgaguac uacugcaccg ccuucaacag agccaaccac     1740

gccagcagcg ugcccagaag caagauccug accgugagag ugauccuggc ccccuggaag     1800

aagggccuga ucgccguggu gaucaucggc gugaucaucg cccugcugau caucgccgcc     1860

aagugcuacu uccugagaaa ggccaaggcc aagcagaugc ccguggagau gagcagaccc     1920

gccgugcccc ugcugaacag caacaacgag aagaugagcg accccaacau ggaggccaac     1980

agccacuacg gccacaacga cgacgugaga aaccacgcca ugaagcccau caacgacaac     2040

aaggagcccc ugaacagcga cgugcaguac accgaggugc aggugagcag cgccgagagc     2100

cacaaggacc ugggcaagaa ggacaccgag accguguaca gcgaggugag aaaggccgug     2160

cccgacgccg uggagagcag auacagcaga accgagggca gccuggacgg caccuga        2217


<210>  3099
<211>  2217
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PECA1__Homo_sapiens__AAA36429

<400>  3099
augcagccca gaugggccca aggcgcuacc auguggcugg gggugcuccu gacacuucug       60

cucugcagcu cccuggaggg acaggaaaac ucuuucacga ucaauagcgu cgacaugaag      120

ucccuuccug auuggaccgu ucagaacggc aaaaaucuga cacuccagug uuuugccgac      180

gugucuacca caagccacgu gaagccgcaa caucagaugc uguucuacaa agaugacguc      240

cuguuuuaua acauuuccuc uaugaaaagc accgaguccu acuucauccc cgaagugcgg      300

auuuaugaua gcgggacaua caaaugcacc guuaucguga auaacaagga gaagacgacc      360

gcggaauauc agcuccuggu cgagggagug ccuucucccc gcguuacacu ugacaaaaag      420

gaggcuauuc agggcgggau cgugagaguc aauuguuccg ugccugaaga gaaagccccc      480

auccacuuua ccauugaaaa gcuggagcuc aacgagaaaa uggugaagcu gaagcgggaa      540

aagaauagcc gcgaucaaaa cuucgucauc cuugaguuuc cuguugagga gcaggacaga      600

gugcugucuu uccggugcca ggcccgcauu aucuccggca uucauaugca gacaagcgaa      660

ucuaccaagu ccgagcucgu gacggucaca gagagcuuuu ccaccccgaa auuccacauc      720

ucucccacag gaaugauuau ggaaggcgcu caacugcaua ucaaguguac cauccaggug      780

acccaccugg cccaggaguu uccugaaauu aucauucaaa aagauaaggc uaucguugcc      840

cacaauagac augggaacaa agcgguguac agcgucaugg ccauggugga gcacuccgga      900

aauuauacau gcaagguuga aagcucucgg auuuccaagg ugagcucuau cgucgugaac      960

aucacggaac ucuucagcaa acccgagcug gaauccucuu uuacccaucu ugaccagggc     1020

gagcgccuga aucucagcug uuccauuccu ggggcucccc cggccaacuu cacaauccag     1080

aaggaagaua ccauugucag ccagacacaa gacuucacca aaaucgcuuc uaaguccgau     1140

agcggaacgu acauuugcac agccggcauc gacaaagugg uuaagaaguc uaacaccgug     1200

cagaucgucg ugugugagau gcugucccag ccuagaauua gcuacgacgc gcaguuugaa     1260

guuaucaaag ggcaaaccau ugaggugcgg ugcgagucca ucucuggaac acuucccauu     1320

agcuaucagc ugcucaagac cuccaaaguc cuggaaaauu cuacaaagaa cagcaaugau     1380

ccugccgugu ucaaagacaa ccccacggag gauguggaau accagugugu ugcugacaau     1440

ugccacuccc acgccaagau gcugagcgag guccuccgcg ugaaggugau cgcucccguc     1500

gaugaggugc agauuucuau ccuguccagc aaaguugugg aaucuggcga ggacaucguc     1560

cuucaaugcg ccgugaacga aggcuccggg ccuauuaccu auaaguuuua cagagagaaa     1620

gaaggaaagc cguucuauca gaugacaagc aaugccaccc aggcuuuuug gacaaaacag     1680

aaggcgucua aggagcaaga gggcgaauac uauuguaccg ccuucaaccg ggcuaaucau     1740

gccagcuccg uuccccgcag caaaauccug acggugagag ucauucucgc cccuuggaag     1800

aaagggcuga ucgcuguggu uauuaucgga gugaucauug cccuucugau cauugcggcu     1860

aagugcuacu uucuccggaa agccaaggcc aaacagaugc ccgucgagau gucuagaccu     1920

gcugugcccc ugcugaacuc caauaacgaa aagaugagcg auccgaauau ggaggccaac     1980

ucccacuacg gccauaauga cgaugugcgc aaccacgcua ugaagccuau caacgacaau     2040

aaagaacccc ucaacucuga uguccaguau accgagguuc aagugagcuc cgccgagucu     2100

cauaaggacc uggggaaaaa ggacacagaa accguguaca gcgagguccg gaaagcggug     2160

ccugaugccg uugaauccag auauucucgc acagagggaa gccuugacgg caccuga        2217


<210>  3100
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PGCB__Homo_sapiens__Q96GW7

<400>  3100

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asp Cys Val Pro Ser Pro Cys His 
                645                 650                 655     


Asn Gly Gly Thr Cys Leu Glu Glu Glu Glu Gly Val Arg Cys Leu Cys 
            660                 665                 670         


Leu Pro Gly Tyr Gly Gly Asp Leu Cys Asp Val Gly Leu Arg Phe Cys 
        675                 680                 685             


Asn Pro Gly Trp Asp Ala Phe Gln Gly Ala Cys Tyr Lys His Phe Ser 
    690                 695                 700                 


Thr Arg Arg Ser Trp Glu Glu Ala Glu Thr Gln Cys Arg Met Tyr Gly 
705                 710                 715                 720 


Ala His Leu Ala Ser Ile Ser Thr Pro Glu Glu Gln Asp Phe Ile Asn 
                725                 730                 735     


Asn Arg Tyr Arg Glu Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile 
            740                 745                 750         


Glu Gly Asp Phe Leu Trp Ser Asp Gly Val Pro Leu Leu Tyr Glu Asn 
        755                 760                 765             


Trp Asn Pro Gly Gln Pro Asp Ser Tyr Phe Leu Ser Gly Glu Asn Cys 
    770                 775                 780                 


Val Val Met Val Trp His Asp Gln Gly Gln Trp Ser Asp Val Pro Cys 
785                 790                 795                 800 


Asn Tyr His Leu Ser Tyr Thr Cys Lys Met Gly Leu Val Ser Cys Gly 
                805                 810                 815     


Pro Pro Pro Glu Leu Pro Leu Ala Gln Val Phe Gly Arg Pro Arg Leu 
            820                 825                 830         


Arg Tyr Glu Val Asp Thr Val Leu Arg Tyr Arg Cys Arg Glu Gly Leu 
        835                 840                 845             


Ala Gln Arg Asn Leu Pro Leu Ile Arg Cys Gln Glu Asn Gly Arg Trp 
    850                 855                 860                 


Glu Ala Pro Gln Ile Ser Cys Val Pro Arg Arg Pro Ala Arg Ala Leu 
865                 870                 875                 880 


His Pro Glu Glu Asp Pro Glu Gly Arg Gln Gly Arg Leu Leu Gly Arg 
                885                 890                 895     


Trp Lys Ala Leu Leu Ile Pro Pro Ser Ser Pro Met Pro Gly Pro 
            900                 905                 910     


<210>  3101
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PGCB__Homo_sapiens__AAG23134

<400>  3101
auggcccagc uguuccugcc ccugcuggca gcccuggucc uggcccaggc uccugcagcu       60

uuagcagaug uucuggaagg agacagcuca gaggaccgcg cuuuucgcgu gcgcaucgcg      120

ggcgacgcgc cacugcaggg cgugcucggc ggcgcccuca ccaucccuug ccacguccac      180

uaccugcggc caccgccgag ccgccgggcu gugcugggcu cuccgcgggu caaguggacu      240

uuccuguccc ggggccggga ggcagaggug cugguggcgc ggggagugcg cgucaaggug      300

aacgaggccu accgguuccg cguggcacug ccugcguacc cagcgucgcu caccgacguc      360

ucccuggcgc ugagcgagcu gcgccccaac gacucaggua ucuaucgcug ugagguccag      420

cacggcaucg augacagcag cgacgcugug gaggucaagg ucaaaggggu cgucuuucuc      480

uaccgagagg gcucugcccg cuaugcuuuc uccuuuucug gggcccagga ggccugugcc      540

cgcauuggag cccacaucgc caccccggag cagcucuaug ccgccuaccu ugggggcuau      600

gagcaaugug augcuggcug gcugucggau cagaccguga gguaucccau ccagacccca      660

cgagaggccu guuacggaga cauggauggc uuccccgggg uccggaacua ugguguggug      720

gacccggaug accucuauga uguguacugu uaugcugaag accuaaaugg agaauuguuc      780

cugggugacc cuccagagaa gcugacauug gaggaagcac gggcguacug ccaggagcgg      840

ggugcagaga uugccaccac gggccaacug uaugcagccu gggauggugg ccuggaccac      900

ugcagcccag gguggcuagc ugauggcagu gugcgcuacc ccaucgucac acccagccag      960

cgcuguggug ggggcuugcc uggugucaag acucucuucc ucuuccccaa ccagacuggc     1020

uuccccaaua agcacagccg cuucaacguc uacugcuucc gagacucggc ccagccuucu     1080

gccaucccug aggccuccaa cccagccucc aacccagccu cugauggacu agaggcuauc     1140

gucacaguga cagagacccu ggaggaacug cagcugccuc aggaagccac agagagugaa     1200

ucccgugggg ccaucuacuc cauccccauc auggaggacg gaggaggugg aagcuccacu     1260

ccagaagacc cagcagaggc cccuaggacg cuccuagaau uugaaacaca auccauggua     1320

ccgcccacgg gguucucaga agaggaaggu aaggcauugg aggaagaaga gaaauaugaa     1380

gaugaagaag agaaagagga ggaagaagaa gaggaggagg uggaggauga ggcucugugg     1440

gcauggccca gcgagcucag cagcccgggc ccugaggccu cucuccccac ugagccagca     1500

gcccaggagg agucacucuc ccaggcgcca gcaagggcag uccugcagcc uggugcauca     1560

ccacuuccug auggagaguc agaagcuucc aggccuccaa ggguccaugg accaccuacu     1620

gagacucugc ccacucccag ggagaggaac cuagcauccc caucaccuuc cacucugguu     1680

gaggcaagag agguggggga ggcaacuggu gguccugagc uaucuggggu cccucgagga     1740

gagagcgagg agacaggaag cuccgagggu gccccuuccc ugcuuccagc cacacgggcc     1800

ccugagggua ccagggagcu ggaggccccc ucugaagaua auucuggaag aacugcccca     1860

gcagggaccu cagugcaggc ccagccagug cugcccacug acagcgccag ccgaggugga     1920

guggccgugg uccccgcauc aggugacugu guccccagcc ccugccacaa uggugggaca     1980

ugcuuggagg aggaggaagg gguccgcugc cuaugucugc cuggcuaugg gggggaccug     2040

ugcgauguug gccuccgcuu cugcaacccc ggcugggacg ccuuccaggg cgccugcuac     2100

aagcacuuuu ccacacgaag gagcugggag gaggcagaga cccagugccg gauguacggc     2160

gcgcaucugg ccagcaucag cacacccgag gaacaggacu ucaucaacaa ccgguaccgg     2220

gaguaccagu ggaucggacu caacgacagg accaucgaag gcgacuucuu guggucggau     2280

ggcguccccc ugcucuauga gaacuggaac ccugggcagc cugacagcua cuuccugucu     2340

ggagagaacu gcguggucau gguguggcau gaucagggac aauggaguga cgugcccugc     2400

aacuaccacc uguccuacac cugcaagaug gggcuggugu ccugugggcc gccaccggag     2460

cugccccugg cucaaguguu cggccgccca cggcugcgcu augaggugga cacugugcuu     2520

cgcuaccggu gccgggaagg acuggcccag cgcaaucugc cgcugauccg augccaagag     2580

aacggucguu gggaggcccc ccagaucucc ugugugccca gaagaccugc ccgagcucug     2640

cacccagagg aggacccaga aggacgucag gggaggcuac ugggacgcug gaaggcgcug     2700

uugauccccc cuuccagccc caugccaggu cccuag                               2736


<210>  3102
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PGCB__Homo_sapiens__AAG23134

<400>  3102
auggcccagc uguuccuccc ccugcuggcc gcgcucgugc uggcccaggc cccggccgcc       60

cuggcggacg uccucgaggg cgacagcucc gaggaccgcg ccuuccgggu gcgcaucgcc      120

ggggacgcgc cccugcaggg cgugcucggg ggcgcccuga ccauccccug ccacguccac      180

uaccugcggc ccccgcccag ccgccgggcc gugcugggga gcccccgcgu gaaguggacc      240

uuccucuccc ggggccgcga ggccgagguc cugguggccc ggggcgugcg cgucaaggug      300

aacgaggccu accgguuccg cguggcgcug cccgccuacc cggccucccu cacggacguc      360

agccuggccc uguccgagcu ccggcccaac gacagcggga ucuaccgcug cgaggugcag      420

cacggcaucg acgacuccag cgacgccgug gaggucaagg ugaagggggu ggucuuccug      480

uaccgggagg gcuccgcgcg cuacgccuuc agcuucuccg gggcccagga ggccugcgcc      540

cggaucggcg cgcacaucgc cacccccgag cagcuguacg ccgccuaccu cggcggguac      600

gagcagugcg acgccggcug gcugagcgac cagaccgugc gcuaccccau ccagaccccg      660

cgggaggcgu gcuacgggga cauggacggc uuccccggcg ugcgcaacua cggggucgug      720

gaccccgacg accuguacga cguguacugc uacgccgagg accucaacgg cgagcuguuc      780

cugggggacc cgcccgagaa gcucacgcug gaggaggccc gggccuacug ccaggagcgc      840

ggcgcggaga ucgccaccac cgggcagcug uacgccgccu gggacggcgg ccucgaccac      900

ugcucccccg gguggcuggc cgacggcagc guccgcuacc ccaucgugac ccccucccag      960

cggugcgggg gcgggcugcc gggcgucaag acccucuucc uguuccccaa ccagaccggc     1020

uuccccaaca agcacagccg cuucaacgug uacugcuucc gggacuccgc gcagcccagc     1080

gccaucccgg aggccagcaa ccccgccucc aaccccgcca gcgacgggcu ggaggcgauc     1140

gugaccguca ccgagacgcu cgaggagcug cagcugcccc aggaggccac cgaguccgag     1200

agccgcggcg ccaucuacuc caucccgauc auggaggacg ggggcggggg cagcuccacc     1260

cccgaggacc ccgccgaggc cccgcggacc cuccuggagu ucgagacgca gagcauggug     1320

ccgcccaccg gcuucuccga ggaggagggg aaggcgcugg aggaggagga gaaguacgag     1380

gacgaggagg agaaggagga ggaggaggag gaggaggagg uggaggacga ggcccucugg     1440

gccuggccca gcgagcuguc cagccccggc cccgaggccu cccugcccac cgagcccgcg     1500

gcccaggagg agagccucuc ccaggccccg gcccgcgccg uccugcagcc cggggcgagc     1560

ccccugcccg acggcgaguc cgaggccagc cggccgcccc gcgugcacgg cccgcccacc     1620

gagacgcucc ccacgccccg ggagcgcaac cuggccuccc ccagccccag cacccuggug     1680

gaggcccggg aggucgggga ggccaccggc gggccggagc uguccggcgu gccccgcggg     1740

gagagcgagg agacgggcuc cagcgagggc gcgcccuccc uccugcccgc cacccgggcc     1800

ccggagggga cccgcgagcu ggaggccccc agcgaggaca acuccggccg gaccgccccc     1860

gcggggacga gcgugcaggc ccagccgguc cuccccaccg acuccgccag ccgcggcggg     1920

guggccgugg uccccgcguc cggcgacugc gugcccagcc cgugccacaa cggcgggacc     1980

ugccuggagg aggaggaggg cgugcggugc cugugccucc ccggguacgg cggggaccug     2040

ugcgacgucg gccugcgcuu cugcaacccc ggcugggacg ccuuccaggg ggccugcuac     2100

aagcacuucu ccacccggcg cagcugggag gaggccgaga cgcagugccg cauguacggc     2160

gcccaccucg cguccaucag cacccccgag gagcaggacu ucaucaacaa ccgguaccgc     2220

gaguaccagu ggaucgggcu gaacgaccgg accaucgagg gcgacuuccu gugguccgac     2280

ggggugccgc uccuguacga gaacuggaac cccggccagc ccgacagcua cuuccugagc     2340

ggcgagaacu gcguggucau gguguggcac gaccaggggc agugguccga cgugcccugc     2400

aacuaccacc ucagcuacac gugcaagaug ggccuggucu ccugcgggcc gccgcccgag     2460

cugccccucg cccagguguu cggccgcccc cggcugcgcu acgaggugga caccguccug     2520

cgguaccgcu gccgggaggg ccucgcccag cgcaaccugc cccugauccg gugccaggag     2580

aacgggcgcu gggaggcgcc ccagaucagc ugcgugcccc ggcgcccggc ccgggcccuc     2640

caccccgagg aggaccccga gggccgccag gggcggcugc ugggccgcug gaaggcccuc     2700

cugaucccgc ccuccagccc caugcccggg cccuga                               2736


<210>  3103
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PGCB__Homo_sapiens__AAG23134

<400>  3103
auggcccagc ucuuccuccc ccuccucgcc gcccucgucc ucgcccaggc ccccgccgcc       60

cucgccgacg uccucgaggg cgacuccucc gaggaccgcg ccuuccgcgu ccgcaucgcc      120

ggcgacgccc cccuccaggg cguccucggc ggcgcccuca ccauccccug ccacguccac      180

uaccuccgcc ccccccccuc ccgccgcgcc guccucggcu ccccccgcgu caaguggacc      240

uuccucuccc gcggccgcga ggccgagguc cucgucgccc gcggcguccg cgucaagguc      300

aacgaggccu accgcuuccg cgucgcccuc cccgccuacc ccgccucccu caccgacguc      360

ucccucgccc ucuccgagcu ccgccccaac gacuccggca ucuaccgcug cgagguccag      420

cacggcaucg acgacuccuc cgacgccguc gaggucaagg ucaagggcgu cgucuuccuc      480

uaccgcgagg gcuccgcccg cuacgccuuc uccuucuccg gcgcccagga ggccugcgcc      540

cgcaucggcg cccacaucgc cacccccgag cagcucuacg ccgccuaccu cggcggcuac      600

gagcagugcg acgccggcug gcucuccgac cagaccgucc gcuaccccau ccagaccccc      660

cgcgaggccu gcuacggcga cauggacggc uuccccggcg uccgcaacua cggcgucguc      720

gaccccgacg accucuacga cgucuacugc uacgccgagg accucaacgg cgagcucuuc      780

cucggcgacc cccccgagaa gcucacccuc gaggaggccc gcgccuacug ccaggagcgc      840

ggcgccgaga ucgccaccac cggccagcuc uacgccgccu gggacggcgg ccucgaccac      900

ugcucccccg gcuggcucgc cgacggcucc guccgcuacc ccaucgucac ccccucccag      960

cgcugcggcg gcggccuccc cggcgucaag acccucuucc ucuuccccaa ccagaccggc     1020

uuccccaaca agcacucccg cuucaacguc uacugcuucc gcgacuccgc ccagcccucc     1080

gccauccccg aggccuccaa ccccgccucc aaccccgccu ccgacggccu cgaggccauc     1140

gucaccguca ccgagacccu cgaggagcuc cagcuccccc aggaggccac cgaguccgag     1200

ucccgcggcg ccaucuacuc cauccccauc auggaggacg gcggcggcgg cuccuccacc     1260

cccgaggacc ccgccgaggc cccccgcacc cuccucgagu ucgagaccca guccaugguc     1320

ccccccaccg gcuucuccga ggaggagggc aaggcccucg aggaggagga gaaguacgag     1380

gacgaggagg agaaggagga ggaggaggag gaggaggagg ucgaggacga ggcccucugg     1440

gccuggcccu ccgagcucuc cucccccggc cccgaggccu cccuccccac cgagcccgcc     1500

gcccaggagg agucccucuc ccaggccccc gcccgcgccg uccuccagcc cggcgccucc     1560

ccccuccccg acggcgaguc cgaggccucc cgcccccccc gcguccacgg cccccccacc     1620

gagacccucc ccaccccccg cgagcgcaac cucgccuccc ccucccccuc cacccucguc     1680

gaggcccgcg aggucggcga ggccaccggc ggccccgagc ucuccggcgu cccccgcggc     1740

gaguccgagg agaccggcuc cuccgagggc gcccccuccc uccuccccgc cacccgcgcc     1800

cccgagggca cccgcgagcu cgaggccccc uccgaggaca acuccggccg caccgccccc     1860

gccggcaccu ccguccaggc ccagcccguc cuccccaccg acuccgccuc ccgcggcggc     1920

gucgccgucg uccccgccuc cggcgacugc guccccuccc ccugccacaa cggcggcacc     1980

ugccucgagg aggaggaggg cguccgcugc cucugccucc ccggcuacgg cggcgaccuc     2040

ugcgacgucg gccuccgcuu cugcaacccc ggcugggacg ccuuccaggg cgccugcuac     2100

aagcacuucu ccacccgccg cuccugggag gaggccgaga cccagugccg cauguacggc     2160

gcccaccucg ccuccaucuc cacccccgag gagcaggacu ucaucaacaa ccgcuaccgc     2220

gaguaccagu ggaucggccu caacgaccgc accaucgagg gcgacuuccu cugguccgac     2280

ggcguccccc uccucuacga gaacuggaac cccggccagc ccgacuccua cuuccucucc     2340

ggcgagaacu gcgucgucau ggucuggcac gaccagggcc agugguccga cguccccugc     2400

aacuaccacc ucuccuacac cugcaagaug ggccucgucu ccugcggccc cccccccgag     2460

cucccccucg cccaggucuu cggccgcccc cgccuccgcu acgaggucga caccguccuc     2520

cgcuaccgcu gccgcgaggg ccucgcccag cgcaaccucc cccucauccg cugccaggag     2580

aacggccgcu gggaggcccc ccagaucucc ugcguccccc gccgccccgc ccgcgcccuc     2640

caccccgagg aggaccccga gggccgccag ggccgccucc ucggccgcug gaaggcccuc     2700

cucauccccc ccuccucccc caugcccggc cccuga                               2736


<210>  3104
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PGCB__Homo_sapiens__AAG23134

<400>  3104
auggcccagc uguuccuccc ccuucuggcu gcauuggugu uagcccaagc gccugcugcc       60

cuggcagacg uccuagaggg cgauagcucc gaagacagag ccuuuagggu ucggaucgcu      120

ggggaugcac cacuccaggg agugcugggu ggcgcccuua ccauuccgug ccacguacau      180

uaccugcgac ccccuccauc ucgccgugcu guguuggggu cacccagagu caaguggaca      240

uuccucagua ggggacggga ggccgaagug cugguugcgc gcggcgugag agucaaagug      300

aacgaggcau auagguuucg gguagcccug ccugcuuacc cagccagccu cacugacguu      360

uccuuagcac ugucugaacu ucgccccaau gauucgggua uauaucgaug ugaggugcag      420

cacgggaucg acgauucaag cgacgcuguc gaggugaagg ugaaaggagu cguuuucuug      480

uacagagaag gcagugccag guaugcguuu uccuucucug gcgcccagga ggcaugcgcu      540

cggauugggg cccauaucgc uacgccugaa caacuguacg ccgcauaucu aggagguuac      600

gagcagugug augccggcug gcucagcgac cagaccgugc guuacccaau ucagacaccg      660

cgcgaggcuu gcuaugggga uauggacgga uuucccggcg uaagaaacua cggugugguc      720

gauccugacg accuguauga uguguacugu uaugcggaag accuuaaugg ggagcuguuc      780

uugggagauc cacccgaaaa gcucacucug gaggaagcaa gggccuacug ccaagagcgg      840

ggcgcugaga ucgccaccac aggccaguua uaugcagccu gggacggggg acuggaucac      900

uguuccccug guuggcucgc ugacggcuca guucgauacc caauagugac ccccagucag      960

cgcugcgggg gaggccuucc gggugucaaa acucuguuuu uguucccuaa ccagacaggg     1020

uuucccaaua agcauagcag auucaacgug uacuguuuua gggauucugc ccaaccaucc     1080

gcaaucccug aagcgucaaa ucccgcuagc aacccagcca gugacggccu agaggcaauu     1140

guaaccguua cggaaacucu ggaggaacuc cagcugcccc aggaggccac cgagucugaa     1200

ucccggggag cuaucuauag cauuccuauc auggaggaug gcgggggagg uucgucuaca     1260

ccagaagacc cggccgaggc accccgcacu cuucuggagu ucgaaaccca auccauggug     1320

ccuccaacag gcuucucaga ggaagagggg aaggcuuugg aagaggagga aaaauacgag     1380

gaugaagagg aaaaggagga ggaagaggaa gaggaagagg ucgaggacga agcccucugg     1440

gcguggccca gugagcugag cuccccugga ccagaagccu cuuuacccac cgagccggcu     1500

gcacaggaag agagccuguc acaggccccu gcuagagccg ugcuacagcc aggcgcaagu     1560

ccccucccug acggugaguc cgaagcgagc aggcccccac guguccacgg gccucccacg     1620

gagacucugc caacaccgcg ggaacgaaau cuugccucuc cuucacccag uaccuuggug     1680

gaggcuagag agguuggcga agccacugga ggcccagagc ugagcggggu gcccagggga     1740

gaauccgagg aaacagguuc uucggagggc gcaccuagcc uccugccagc uacccgcgcc     1800

cccgagggga cgcgggaacu ugaggcaccu uccgaagaua acucaggaag aaccgccccg     1860

gcuggcacaa guguacaagc gcagccaguc cugcccacug acucugccag cagggguggg     1920

guggcaguug ugccugcuuc cggcgauugc gucccaucac ccugucacaa uggagggacc     1980

ugcuuggagg aagaggaggg cgugcgcugc cucugucugc cuggauaugg cggugacuua     2040

ugcgauguag ggcugcgauu uuguaacccg ggaugggacg ccuuccaggg cgccugcuac     2100

aaacauuuua gcacacggcg uucuugggaa gaggcugaaa cucaguguag aauguauggu     2160

gcacaccuag ccuccauaag uacccccgag gaacaagauu ucauuaauaa cagguaccgc     2220

gaguaucagu ggaucggccu caaugaccgg acaauugagg gggauuuucu guggagcgac     2280

ggagugccac uuuuguacga aaacuggaac ccuggccagc ccgauucuua cuuccugucc     2340

ggggagaauu gcguugucau gguguggcau gaccagggac aauggucaga ugugccaugu     2400

aacuaucacc ucaguuauac cugcaagaug ggccugguca gcuguggucc ucccccagaa     2460

uuaccgcugg cgcagguuuu ugggagaccu aggcuucgau acgaggugga cacuguguug     2520

cgcuaccggu gcagagaggg acucgcucag aggaaucugc cccuaauccg uugucaggaa     2580

aacggccgcu gggaggcccc acaaaucucg ugcguacccc ggagaccugc aagggcccug     2640

cacccagaag aggaccccga aggucgacag ggccggcucc uggggcgcug gaaagcucuu     2700

uugauuccuc cguccucucc aaugcccgga ccuuga                               2736


<210>  3105
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PGCB__Homo_sapiens__AAG23134

<400>  3105
auggcccagc uguuccugcc ccugcuggcc gcccuggugc uggcccaggc ccccgccgcc       60

cuggccgacg ugcuggaggg cgacagcagc gaggacagag ccuucagagu gagaaucgcc      120

ggcgacgccc cccugcaggg cgugcugggc ggcgcccuga ccauccccug ccacgugcac      180

uaccugagac ccccccccag cagaagagcc gugcugggca gccccagagu gaaguggacc      240

uuccugagca gaggcagaga ggccgaggug cugguggcca gaggcgugag agugaaggug      300

aacgaggccu acagauucag aguggcccug cccgccuacc ccgccagccu gaccgacgug      360

agccuggccc ugagcgagcu gagacccaac gacagcggca ucuacagaug cgaggugcag      420

cacggcaucg acgacagcag cgacgccgug gaggugaagg ugaagggcgu gguguuccug      480

uacagagagg gcagcgccag auacgccuuc agcuucagcg gcgcccagga ggccugcgcc      540

agaaucggcg cccacaucgc cacccccgag cagcuguacg ccgccuaccu gggcggcuac      600

gagcagugcg acgccggcug gcugagcgac cagaccguga gauaccccau ccagaccccc      660

agagaggccu gcuacggcga cauggacggc uuccccggcg ugagaaacua cggcguggug      720

gaccccgacg accuguacga cguguacugc uacgccgagg accugaacgg cgagcuguuc      780

cugggcgacc cccccgagaa gcugacccug gaggaggcca gagccuacug ccaggagaga      840

ggcgccgaga ucgccaccac cggccagcug uacgccgccu gggacggcgg ccuggaccac      900

ugcagccccg gcuggcuggc cgacggcagc gugagauacc ccaucgugac ccccagccag      960

agaugcggcg gcggccugcc cggcgugaag acccuguucc uguuccccaa ccagaccggc     1020

uuccccaaca agcacagcag auucaacgug uacugcuuca gagacagcgc ccagcccagc     1080

gccauccccg aggccagcaa ccccgccagc aaccccgcca gcgacggccu ggaggccauc     1140

gugaccguga ccgagacccu ggaggagcug cagcugcccc aggaggccac cgagagcgag     1200

agcagaggcg ccaucuacag cauccccauc auggaggacg gcggcggcgg cagcagcacc     1260

cccgaggacc ccgccgaggc ccccagaacc cugcuggagu ucgagaccca gagcauggug     1320

ccccccaccg gcuucagcga ggaggagggc aaggcccugg aggaggagga gaaguacgag     1380

gacgaggagg agaaggagga ggaggaggag gaggaggagg uggaggacga ggcccugugg     1440

gccuggccca gcgagcugag cagccccggc cccgaggcca gccugcccac cgagcccgcc     1500

gcccaggagg agagccugag ccaggccccc gccagagccg ugcugcagcc cggcgccagc     1560

ccccugcccg acggcgagag cgaggccagc agacccccca gagugcacgg cccccccacc     1620

gagacccugc ccacccccag agagagaaac cuggccagcc ccagccccag cacccuggug     1680

gaggccagag aggugggcga ggccaccggc ggccccgagc ugagcggcgu gcccagaggc     1740

gagagcgagg agaccggcag cagcgagggc gcccccagcc ugcugcccgc caccagagcc     1800

cccgagggca ccagagagcu ggaggccccc agcgaggaca acagcggcag aaccgccccc     1860

gccggcacca gcgugcaggc ccagcccgug cugcccaccg acagcgccag cagaggcggc     1920

guggccgugg ugcccgccag cggcgacugc gugcccagcc ccugccacaa cggcggcacc     1980

ugccuggagg aggaggaggg cgugagaugc cugugccugc ccggcuacgg cggcgaccug     2040

ugcgacgugg gccugagauu cugcaacccc ggcugggacg ccuuccaggg cgccugcuac     2100

aagcacuuca gcaccagaag aagcugggag gaggccgaga cccagugcag aauguacggc     2160

gcccaccugg ccagcaucag cacccccgag gagcaggacu ucaucaacaa cagauacaga     2220

gaguaccagu ggaucggccu gaacgacaga accaucgagg gcgacuuccu guggagcgac     2280

ggcgugcccc ugcuguacga gaacuggaac cccggccagc ccgacagcua cuuccugagc     2340

ggcgagaacu gcguggugau gguguggcac gaccagggcc aguggagcga cgugcccugc     2400

aacuaccacc ugagcuacac cugcaagaug ggccugguga gcugcggccc cccccccgag     2460

cugccccugg cccagguguu cggcagaccc agacugagau acgaggugga caccgugcug     2520

agauacagau gcagagaggg ccuggcccag agaaaccugc cccugaucag augccaggag     2580

aacggcagau gggaggcccc ccagaucagc ugcgugccca gaagacccgc cagagcccug     2640

caccccgagg aggaccccga gggcagacag ggcagacugc ugggcagaug gaaggcccug     2700

cugauccccc ccagcagccc caugcccggc cccuga                               2736


<210>  3106
<211>  2736
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PGCB__Homo_sapiens__AAG23134

<400>  3106
auggcccagc uguuccuccc ccugcuugcu gcccuggugc ucgcgcaagc uccugccgcc       60

cuggcugacg uccuugaggg cgauagcucc gaagacagag ccuuucgggu ucgcaucgcu      120

ggggaugccc cgcugcaggg agugcucggc ggggcgcuga ccauucccug ccacgugcau      180

uaccugagac cucccccuuc ucggcgcgcc guccucggaa gccccagagu gaaguggaca      240

uuccuguccc ggggccgcga ggcugaaguu cuuguggcca gagggguccg ggugaaaguu      300

aacgaggcuu aucgcuuuag aguggcccug ccugcguacc cggccucucu cacggacguc      360

agccuggcuc uuuccgaacu gcggcccaau gauucuggaa ucuaucgcug ugaggugcag      420

cacggcauug acgauagcuc cgacgccgug gaggucaagg uuaaaggcgu gguguuccuc      480

uacagagaag ggagcgcucg guaugccuuu ucuuucuccg gagcccagga ggcuugcgcg      540

cgcaucggcg cccauauugc uaccccugaa caacuguacg ccgccuaucu gggcggauac      600

gagcagugug augcuggcug gcucagcgac cagacaguca gauaccccau ccagaccccu      660

cgggaggccu gcuaugggga uauggacgga uuucccggcg ugagaaacua cggcguugug      720

gauccggacg accuguauga ugucuacugu uaugcggaag accuuaaugg ggagcuguuc      780

cucggagauc cucccgaaaa gcugacacuu gaggaagcuc gcgccuacug ccaagagcgg      840

ggcgccgaga ucgcuaccac agggcagcug uaugccgcuu gggacggagg ccucgaucac      900

uguucuccug gguggcuggc cgacggaucc gugagauacc ccauuguuac ccccagccag      960

cgcugcggcg gcgggcugcc uggagugaaa acgcucuuuc uguucccgaa ccagaccggc     1020

uuucccaaua agcauucucg guucaacguc uacuguuuua gagauuccgc gcaaccuagc     1080

gccauccccg aagccuccaa uccugccucu aaccccgcua gcgacgggcu ugaggccauu     1140

gugacaguca ccgaaacacu ggaggaacuc cagcugccgc aggaggcgac cgaguccgaa     1200

agccgcggag ccaucuauuc uauuccuauc auggaggaug gcgggggcgg auccagcacg     1260

cccgaagacc cugcugaggc uccccggaca cuucuggagu ucgaaaccca aucuauggug     1320

ccucccacag gcuucagcga ggaagagggg aaggcucucg aagaggagga aaaauacgag     1380

gaugaagagg aaaaggagga ggaagaggaa gaggaagagg uugaggacga agcccugugg     1440

gccuggccgu ccgagcuguc uagcccugga cccgaggcuu cccuccccac cgaaccugcg     1500

gcccaggaag agagccuguc ucaggcuccg gccagagccg ugcuucagcc cggcgcuucc     1560

ccucugcccg acggggagag cgaagccucu cgcccucccc ggguccacgg accucccacc     1620

gagacacucc cgacgccuag agaacgcaau cuggcguccc ccagcccuuc cacccuggug     1680

gaggcucggg agguuggcga agccacaggg ggccccgagc uuucuggagu gccgagaggc     1740

gaaagcgagg aaaccggguc cucugaggga gccccuagcc uccugcccgc uacacgggcc     1800

ccugagggca cccgcgaacu ggaggcgccc uccgaagaua acagcgggag aacggcuccc     1860

gccggaacau cuguccaagc ccagccugug cucccgaccg acuccgcuag ccggggcggg     1920

guggccguug uccccgcuuc uggcgauugc gugccuuccc ccugucacaa uggagggacc     1980

ugccuggagg aagaggaggg ggugagaugc cuuugucugc cuggauaugg cggggaccuc     2040

ugcgaugucg gacugcgcuu uuguaacccc ggcugggacg ccuuccaggg ggcgugcuac     2100

aaacauuuua gcacacggag aucuugggaa gaggccgaaa cccagugucg cauguauggc     2160

gcucaccugg ccagcauuuc cacaccugag gaacaagauu ucaucaauaa cagauaccgg     2220

gaguaucagu ggaucggacu uaaugaccgc acgauugagg gcgauuuucu cuggagcgac     2280

ggggugccgc ugcuguacga aaacuggaac cccggacagc cugauucuua cuuccucucc     2340

ggcgagaauu gcguugugau ggucuggcau gaccaggggc aauggagcga ugugcccugu     2400

aacuaucacc uguccuauac cugcaagaug ggacuuguuu cuuguggccc ucccccggaa     2460

cugccucucg cucagguguu uggcagaccc cggcugcgcu acgaggucga cacagugcug     2520

agauaccggu gccgcgaggg gcuugcccag agaaaucucc cccugauccg gugucaggaa     2580

aacggacgcu gggaggcccc ucaaauuagc ugcguuccca gacggccugc uagagcgcug     2640

cacccggaag aggaccccga aggccgccag gggcggcucc ugggaagaug gaaagcccuu     2700

cugaucccuc ccuccucucc uaugcccggc ccguga                               2736


<210>  3107
<211>  1106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PGFRB__Homo_sapiens__P09619

<400>  3107

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu 
        995                 1000                1005            


Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro 
    1010                1015                1020                


Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly 
1025                1030                1035                1040


Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser 
                1045                1050                1055    


Thr Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro 
            1060                1065                1070        


Glu Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu Gln 
        1075                1080                1085            


Leu Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser 
    1090                1095                1100                


Phe Leu 
1105    


<210>  3108
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PGFRB__Homo_sapiens__AAA60049

<400>  3108
augcggcuuc cgggugcgau gccagcucug gcccucaaag gcgagcugcu guugcugucu       60

cuccuguuac uucuggaacc acagaucucu cagggccugg ucgucacacc cccggggcca      120

gagcuugucc ucaaugucuc cagcaccuuc guucugaccu gcucggguuc agcuccggug      180

gugugggaac ggauguccca ggagccccca caggaaaugg ccaaggccca ggauggcacc      240

uucuccagcg ugcucacacu gaccaaccuc acugggcuag acacgggaga auacuuuugc      300

acccacaaug acucccgugg acuggagacc gaugagcgga aacggcucua caucuuugug      360

ccagauccca ccgugggcuu ccucccuaau gaugccgagg aacuauucau cuuucucacg      420

gaaauaacug agaucaccau uccaugccga guaacagacc cacagcuggu ggugacacug      480

cacgagaaga aaggggacgu ugcacugccu guccccuaug aucaccaacg uggcuuuucu      540

gguaucuuug aggacagaag cuacaucugc aaaaccacca uuggggacag ggagguggau      600

ucugaugccu acuaugucua cagacuccag gugucaucca ucaacgucuc ugugaacgca      660

gugcagacug ugguccgcca gggugagaac aucacccuca ugugcauugu gaucgggaau      720

gaggugguca acuucgagug gacauacccc cgcaaagaaa gugggcggcu gguggagccg      780

gugacugacu uccucuugga uaugccuuac cacauccgcu ccauccugca cauccccagu      840

gccgaguuag aagacucggg gaccuacacc ugcaauguga cggagagugu gaaugaccau      900

caggaugaaa aggccaucaa caucaccgug guugagagcg gcuacgugcg gcuccuggga      960

gaggugggca cacuacaauu ugcugagcug caucggagcc ggacacugca gguaguguuc     1020

gaggccuacc caccgcccac uguccugugg uucaaagaca accgcacccu gggcgacucc     1080

agcgcuggcg aaaucgcccu guccacgcgc aacgugucgg agacccggua ugugucagag     1140

cugacacugg uucgcgugaa gguggcagag gcuggccacu acaccaugcg ggccuuccau     1200

gaggaugcug agguccagcu cuccuuccag cuacagauca augucccugu ccgagugcug     1260

gagcuaagug agagccaccc ugacaguggg gaacagacag uccgcugucg uggccggggc     1320

augccccagc cgaacaucau cuggucugcc ugcagagacc ucaaaaggug uccacgugag     1380

cugccgccca cgcugcuggg gaacaguucc gaagaggaga gccagcugga gacuaacgug     1440

acguacuggg aggaggagca ggaguuugag guggugagca cacugcgucu gcagcacgug     1500

gaucggccac ugucggugcg cugcacgcug cgcaacgcug ugggccagga cacgcaggag     1560

gucaucgugg ugccacacuc cuugcccuuu aagguggugg ugaucucagc cauccuggcc     1620

cugguggugc ucaccaucau cucccuuauc auccucauca ugcuuuggca gaagaagcca     1680

cguuacgaga uccgauggaa ggugauugag ucugugagcu cugacggcca ugaguacauc     1740

uacguggacc ccaugcagcu gcccuaugac uccacguggg agcugccgcg ggaccagcuu     1800

gugcugggac gcacccucgg cucuggggcc uuugggcagg ugguggaggc cacggcucau     1860

ggccugagcc auucucaggc cacgaugaaa guggccguca agaugcuuaa auccacagcc     1920

cgcagcagug agaagcaagc ccuuaugucg gagcugaaga ucaugaguca ccuugggccc     1980

caccugaacg uggucaaccu guugggggcc ugcaccaaag gaggacccau cuauaucauc     2040

acugaguacu gccgcuacgg agaccuggug gacuaccugc accgcaacaa acacaccuuc     2100

cugcagcacc acuccgacaa gcgccgcccg cccagcgcgg agcucuacag caaugcucug     2160

cccguugggc ucccccugcc cagccaugug uccuugaccg gggagagcga cgguggcuac     2220

auggacauga gcaaggacga gucgguggac uaugugccca ugcuggacau gaaaggagac     2280

gucaaauaug cagacaucga guccuccaac uacauggccc cuuacgauaa cuacguuccc     2340

ucugccccug agaggaccug ccgagcaacu uugaucaacg agucuccagu gcuaagcuac     2400

auggaccucg ugggcuucag cuaccaggug gccaauggca uggaguuucu ggccuccaag     2460

aacugcgucc acagagaccu ggcggcuagg aacgugcuca ucugugaagg caagcugguc     2520

aagaucugug acuuuggccu ggcucgagac aucaugcggg acucgaauua caucuccaaa     2580

ggcagcaccu uuuugccuuu aaaguggaug gcuccggaga gcaucuucaa cagccucuac     2640

accacccuga gcgacgugug guccuucggg auccugcucu gggagaucuu caccuugggu     2700

ggcaccccuu acccagagcu gcccaugaac gagcaguucu acaaugccau caaacggggu     2760

uaccgcaugg cccagccugc ccaugccucc gacgagaucu augagaucau gcagaagugc     2820

ugggaagaga aguuugagau ucggcccccc uucucccagc uggugcugcu ucucgagaga     2880

cuguugggcg aagguuacaa aaagaaguac cagcaggugg augaggaguu ucugaggagu     2940

gaccacccag ccauccuucg gucccaggcc cgcuugccug gguuccaugg ccuccgaucu     3000

ccccuggaca ccagcuccgu ccucuauacu gccgugcagc ccaaugaggg ugacaacgac     3060

uauaucaucc cccugccuga ccccaaaccc gagguugcug acgagggccc acuggagggu     3120

ucccccagcc uagccagcuc cacccugaau gaagucaaca ccuccucaac caucuccugu     3180

gacagccccc uggagcccca ggacgaacca gagccagagc cccagcuuga gcuccaggug     3240

gagccggagc cagagcugga acaguugccg gauucggggu gcccugcgcc ucgggcggaa     3300

gcagaggaua gcuuccugua g                                               3321


<210>  3109
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PGFRB__Homo_sapiens__AAA60049

<400>  3109
augcgccugc ccggcgccau gccggcccuc gcgcugaagg gggagcugcu ccugcugagc       60

cuccugcugc uccuggagcc ccagaucucc cagggccugg uggucacccc gcccgggccc      120

gagcucgugc ugaacgugag cuccaccuuc guccugacgu gcagcggcuc cgcccccgug      180

gugugggagc ggaugagcca ggagccgccc caggagaugg ccaaggccca ggacgggacc      240

uucuccagcg uccucacccu gaccaaccug acgggccucg acaccggcga guacuucugc      300

acccacaacg acucccgcgg gcuggagacc gacgagcgga agcgccugua caucuucgug      360

cccgacccca cggugggcuu ccuccccaac gacgccgagg agcuguucau cuuccugacc      420

gagaucaccg agaucaccau ccccugccgg gucacggacc cgcagcucgu ggugacccug      480

cacgagaaga agggggacgu cgcgcugccc gugcccuacg accaccagcg cggcuucagc      540

gggaucuucg aggaccgguc cuacaucugc aagaccacca ucggcgaccg cgagguggac      600

agcgacgccu acuacgucua ccggcuccag guguccagca ucaacguguc cgucaacgcc      660

gugcagacgg ugguccgcca gggcgagaac aucacccuga ugugcaucgu gaucgggaac      720

gaggugguca acuucgagug gaccuacccc cggaaggaga gcggccgccu gguggagccg      780

gucaccgacu uccuccugga caugcccuac cacauccggu ccauccugca cauccccagc      840

gccgagcucg aggacuccgg gacguacacg ugcaacguga ccgagagcgu gaacgaccac      900

caggacgaga aggcgaucaa caucaccguc guggagagcg gcuacgugcg ccugcugggc      960

gaggucggga cccuccaguu cgccgagcug caccgguccc gcacccucca ggugguguuc     1020

gaggccuacc cgccgcccac cguccugugg uucaaggaca accggacccu gggcgacagc     1080

uccgccgggg agaucgcccu gagcacgcgc aacguguccg agacccggua cgugagcgag     1140

cucacccugg uccgcgugaa gguggcggag gccggccacu acaccaugcg ggccuuccac     1200

gaggacgccg agguccagcu guccuuccag cuccagauca acgugcccgu gcgcguccug     1260

gagcugagcg agucccaccc cgacagcggg gagcagacgg ugcgcugccg gggccgcggc     1320

augccccagc ccaacaucau cugguccgcc ugccgggacc ucaagcgcug cccccgggag     1380

cugcccccga cccugcuggg gaacagcucc gaggaggaga gccagcucga gaccaacgug     1440

accuacuggg aggaggagca ggaguucgag gucgugucca cgcugcgccu gcagcacgug     1500

gaccggcccc ucagcguccg cugcacccug cggaacgcgg ugggccagga cacccaggag     1560

gugaucgucg ugccccacuc ccugccguuc aagguggucg ugaucagcgc cauccucgcc     1620

cugguggucc ugaccaucau cucccucauc auccugauca ugcuguggca gaagaagccc     1680

cgcuacgaga uccgguggaa ggugaucgag agcgugagcu ccgacgggca cgaguacauc     1740

uacgucgacc ccaugcagcu ccccuacgac agcaccuggg agcugccgcg cgaccagcug     1800

gugcucggcc ggacgcuggg guccggcgcc uucggccagg uggucgaggc caccgcgcac     1860

gggcugagcc acucccaggc caccaugaag guggccguga agaugcucaa gagcaccgcc     1920

cgcuccagcg agaagcaggc ccugaugucc gagcugaaga ucaugagcca ccucggcccc     1980

caccugaacg ucgugaaccu gcucggggcg ugcacgaagg gcgggcccau cuacaucauc     2040

accgaguacu gccgguacgg cgaccuggug gacuaccugc accgcaacaa gcacaccuuc     2100

cuccagcacc acuccgacaa gcggcggccc ccgagcgccg agcuguacuc caacgcccug     2160

cccgucggcc ucccccugcc cagccacgug ucccugaccg gggagagcga cggcggguac     2220

auggacaugu ccaaggacga gagcguggac uacgucccga ugcucgacau gaagggcgac     2280

gugaaguacg ccgacaucga gagcuccaac uacauggcgc ccuacgacaa cuacgugccc     2340

agcgcccccg agcgcacgug ccgcgccacc cugaucaacg aguccccggu ccugagcuac     2400

auggaccucg ugggcuucuc cuaccagguc gccaacggga uggaguuccu ggccagcaag     2460

aacugcgugc accgcgaccu ggcggcccgg aacgugcuca ucugcgaggg caagcugguc     2520

aagaucugcg acuucgggcu ggcccgcgac aucaugcggg acuccaacua caucagcaag     2580

ggcuccaccu uccucccccu gaaguggaug gcccccgaga gcaucuucaa cucccuguac     2640

accacgcuca gcgacgugug guccuucggg auccugcugu gggagaucuu cacccucggc     2700

ggcacccccu acccggagcu gcccaugaac gagcaguucu acaacgccau caagcgcggg     2760

uaccggaugg cgcagcccgc ccacgccagc gacgagaucu acgagaucau gcagaagugc     2820

ugggaggaga aguucgagau ccggcccccg uucucccagc uggugcuccu gcuggagcgc     2880

cuccugggcg agggguacaa gaagaaguac cagcaggucg acgaggaguu ccugcgcagc     2940

gaccaccccg ccauccuccg gucccaggcc cgccugcccg gcuuccacgg gcugcggagc     3000

ccgcucgaca ccuccagcgu gcuguacacg gcggugcagc ccaacgaggg cgacaacgac     3060

uacaucaucc cccugcccga cccgaagccc gaggucgccg acgagggccc ccucgagggg     3120

agccccuccc uggccagcuc cacccugaac gaggugaaca ccagcuccac caucagcugc     3180

gacuccccgc ucgagcccca ggacgagccc gagcccgagc cgcagcugga gcuccaggug     3240

gagcccgagc ccgagcugga gcagcugccc gacagcggcu gcccggcgcc ccgcgccgag     3300

gccgaggacu ccuuccugug a                                               3321


<210>  3110
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PGFRB__Homo_sapiens__AAA60049

<400>  3110
augcgccucc ccggcgccau gcccgcccuc gcccucaagg gcgagcuccu ccuccucucc       60

cuccuccucc uccucgagcc ccagaucucc cagggccucg ucgucacccc ccccggcccc      120

gagcucgucc ucaacgucuc cuccaccuuc guccucaccu gcuccggcuc cgcccccguc      180

gucugggagc gcauguccca ggagcccccc caggagaugg ccaaggccca ggacggcacc      240

uucuccuccg uccucacccu caccaaccuc accggccucg acaccggcga guacuucugc      300

acccacaacg acucccgcgg ccucgagacc gacgagcgca agcgccucua caucuucguc      360

cccgacccca ccgucggcuu ccuccccaac gacgccgagg agcucuucau cuuccucacc      420

gagaucaccg agaucaccau ccccugccgc gucaccgacc cccagcucgu cgucacccuc      480

cacgagaaga agggcgacgu cgcccucccc guccccuacg accaccagcg cggcuucucc      540

ggcaucuucg aggaccgcuc cuacaucugc aagaccacca ucggcgaccg cgaggucgac      600

uccgacgccu acuacgucua ccgccuccag gucuccucca ucaacgucuc cgucaacgcc      660

guccagaccg ucguccgcca gggcgagaac aucacccuca ugugcaucgu caucggcaac      720

gaggucguca acuucgagug gaccuacccc cgcaaggagu ccggccgccu cgucgagccc      780

gucaccgacu uccuccucga caugcccuac cacauccgcu ccauccucca cauccccucc      840

gccgagcucg aggacuccgg caccuacacc ugcaacguca ccgaguccgu caacgaccac      900

caggacgaga aggccaucaa caucaccguc gucgaguccg gcuacguccg ccuccucggc      960

gaggucggca cccuccaguu cgccgagcuc caccgcuccc gcacccucca ggucgucuuc     1020

gaggccuacc ccccccccac cguccucugg uucaaggaca accgcacccu cggcgacucc     1080

uccgccggcg agaucgcccu cuccacccgc aacgucuccg agacccgcua cgucuccgag     1140

cucacccucg uccgcgucaa ggucgccgag gccggccacu acaccaugcg cgccuuccac     1200

gaggacgccg agguccagcu cuccuuccag cuccagauca acguccccgu ccgcguccuc     1260

gagcucuccg agucccaccc cgacuccggc gagcagaccg uccgcugccg cggccgcggc     1320

augccccagc ccaacaucau cugguccgcc ugccgcgacc ucaagcgcug cccccgcgag     1380

cuccccccca cccuccucgg caacuccucc gaggaggagu cccagcucga gaccaacguc     1440

accuacuggg aggaggagca ggaguucgag gucgucucca cccuccgccu ccagcacguc     1500

gaccgccccc ucuccguccg cugcacccuc cgcaacgccg ucggccagga cacccaggag     1560

gucaucgucg ucccccacuc ccuccccuuc aaggucgucg ucaucuccgc cauccucgcc     1620

cucgucgucc ucaccaucau cucccucauc auccucauca ugcucuggca gaagaagccc     1680

cgcuacgaga uccgcuggaa ggucaucgag uccgucuccu ccgacggcca cgaguacauc     1740

uacgucgacc ccaugcagcu ccccuacgac uccaccuggg agcucccccg cgaccagcuc     1800

guccucggcc gcacccucgg cuccggcgcc uucggccagg ucgucgaggc caccgcccac     1860

ggccucuccc acucccaggc caccaugaag gucgccguca agaugcucaa guccaccgcc     1920

cgcuccuccg agaagcaggc ccucaugucc gagcucaaga ucauguccca ccucggcccc     1980

caccucaacg ucgucaaccu ccucggcgcc ugcaccaagg gcggccccau cuacaucauc     2040

accgaguacu gccgcuacgg cgaccucguc gacuaccucc accgcaacaa gcacaccuuc     2100

cuccagcacc acuccgacaa gcgccgcccc cccuccgccg agcucuacuc caacgcccuc     2160

cccgucggcc ucccccuccc cucccacguc ucccucaccg gcgaguccga cggcggcuac     2220

auggacaugu ccaaggacga guccgucgac uacgucccca ugcucgacau gaagggcgac     2280

gucaaguacg ccgacaucga guccuccaac uacauggccc ccuacgacaa cuacgucccc     2340

uccgcccccg agcgcaccug ccgcgccacc cucaucaacg agucccccgu ccucuccuac     2400

auggaccucg ucggcuucuc cuaccagguc gccaacggca uggaguuccu cgccuccaag     2460

aacugcgucc accgcgaccu cgccgcccgc aacguccuca ucugcgaggg caagcucguc     2520

aagaucugcg acuucggccu cgcccgcgac aucaugcgcg acuccaacua caucuccaag     2580

ggcuccaccu uccucccccu caaguggaug gcccccgagu ccaucuucaa cucccucuac     2640

accacccucu ccgacgucug guccuucggc auccuccucu gggagaucuu cacccucggc     2700

ggcacccccu accccgagcu ccccaugaac gagcaguucu acaacgccau caagcgcggc     2760

uaccgcaugg cccagcccgc ccacgccucc gacgagaucu acgagaucau gcagaagugc     2820

ugggaggaga aguucgagau ccgccccccc uucucccagc ucguccuccu ccucgagcgc     2880

cuccucggcg agggcuacaa gaagaaguac cagcaggucg acgaggaguu ccuccgcucc     2940

gaccaccccg ccauccuccg cucccaggcc cgccuccccg gcuuccacgg ccuccgcucc     3000

ccccucgaca ccuccuccgu ccucuacacc gccguccagc ccaacgaggg cgacaacgac     3060

uacaucaucc cccuccccga ccccaagccc gaggucgccg acgagggccc ccucgagggc     3120

ucccccuccc ucgccuccuc cacccucaac gaggucaaca ccuccuccac caucuccugc     3180

gacucccccc ucgagcccca ggacgagccc gagcccgagc cccagcucga gcuccagguc     3240

gagcccgagc ccgagcucga gcagcucccc gacuccggcu gccccgcccc ccgcgccgag     3300

gccgaggacu ccuuccucug a                                               3321


<210>  3111
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PGFRB__Homo_sapiens__AAA60049

<400>  3111
augagacugc ccggcgccau gccugcucuc gcacuuaagg gggagcuguu guuacugagc       60

cuacuccugc uucuggaacc acagaucucc caaggauugg uggucacccc gcccgguccu      120

gagcucguuc ugaacguguc uucaacauuc guacugacuu gcaguggcag cgccccagug      180

gucugggaaa ggauguccca ggagcccccu caggaaaugg cgaaagcuca ggacgggacg      240

uuuucuucgg ugcucaccuu aacaaaucug acuggacuug auaccggcga guacuucugu      300

acacacaacg acucacgggg uuuggagacc gaugaacgca agcgacugua uauuuuuguu      360

ccagacccca cugugggguu ccuaccuaau gaugccgagg aacucuuuau auuccugaca      420

gagaucaccg agauuacgau cccaugccgu gucacugacc cgcaacuugu gguaacccug      480

caugaaaaga agggagaugu ugcauugccc gugccuuacg accaccagag aggcuuuagc      540

ggcauuuucg aggauaggag uuauaucugu aaaacaacua uaggggaccg ggaagucgau      600

uccgacgccu acuaugugua ccgccuccag gugucuagca ucaacgucuc cguuaaugcu      660

gugcagaccg uagugagaca aggagagaac auuacacuga ugugcaucgu cauugguaau      720

gaagugguua acuuugagug gaccuaucca aggaaggagu caggccgguu aguggaaccc      780

gucacggauu uccugcucga caugccuuac cauauccgca guauacuuca cauuccaagc      840

gcagagcugg aagacucugg gacuuacaca uguaauguga ccgaguccgu aaacgaucau      900

caggacgaaa aggccaucaa uauuacuguu guggagucag gauauguccg auugcuaggc      960

gaggugggua cacugcaguu ugcugaacuc cacagaagca ggacccugca ggucguguuc     1020

gaggccuauc ccccgccuac gguucuuugg uuuaaagaua accggacccu gggggacagu     1080

ucugcgggag aaaucgcauu guccacacgu aaugugagcg agacucgcua cguaucggaa     1140

cucacccugg ucagagugaa gguugccgag gcuggccacu acacaaugag ggccuuccau     1200

gaggaugcag aagugcaauu aucuuuccag cugcagauca acguccccgu gcggguacua     1260

gagcucuccg aaucacaccc agacaguggc gagcaaacug ugcgaugccg cgggagagga     1320

augccucagc ccaauauuau auggagcgcu uguagggauc ugaaacggug cccacgcgag     1380

cuucccccua ccuugcuggg uaacuccucu gaagaggaaa gccagcucga gacaaacguu     1440

accuauuggg aagaggagca ggaauuugag gucgugucaa cucugagacu ucaacaugug     1500

gacaggccac ugaguguccg uuguacguug cggaaugccg uuggccagga uacacaggaa     1560

gugaucgugg uaccgcacuc ccuccccuuc aaggucgugg uuauuagcgc gauccuggcc     1620

uuaguggucc ugaccauaau uucucuaauc auccucauua ugcuguggca gaaaaagccu     1680

cgauacgaga ucagauggaa ggugauugaa ucaguuagua gcgacgggca cgaguauaua     1740

uacguggauc caaugcaacu ucccuacgac uccacuuggg aguugccuag ggaccagcug     1800

guacucggac gcacccuggg cucuggugca uuugggcagg ucguggaagc uacagcccau     1860

ggcuuaucgc acagccaggc uaccaugaaa guggccguca agaugcugaa auccacugca     1920

cggucaagug agaagcaagc ccuuaugucu gaauugaaaa ucaugagcca ucucggacca     1980

caccugaacg uugugaaucu acugggcgcu ugcacaaaag ggggacccau uuauaucauc     2040

acggaguacu guagauaugg ugaucucgua gacuaccugc auaggaacaa acacaccuuc     2100

cuucagcacc auuccgauaa gcgccgaccg ccuucagcgg aauuguauag caaugcacug     2160

ccagugggcu uaccccuccc uucucacguc ucccugacug gggagaguga cggaggcuac     2220

auggauauga gcaaggacga gucuguggau uauguuccca ugcuugacau gaaaggugau     2280

gugaaguacg ccgacauuga auccucaaac uacauggcuc cauaugauaa uuacgucccu     2340

agugcccccg agcggacaug ccgugcaacc cugauaaacg aaagcccagu guugucguau     2400

auggaccucg uuggguuuuc cuaccaggug gccaauggca uggaguuccu ggcuucuaaa     2460

aacugcgucc auagagaucu agccgcaagg aauguacuga ucugugaggg aaagcucgug     2520

aaaauuugcg acuuuggccu ggcgcgcgac aucaugcggg auagcaacua uauuucaaag     2580

gggaguacau uccuuccguu gaaguggaug gcuccugaau ccaucuuuaa uucucuguac     2640

acuaccuuaa gcgacguuug guccuucgga auacuccugu gggagaucuu uacgcuuggu     2700

ggcacccccu auccagaacu gcccaugaac gagcaguucu acaaugccau uaaaagaggg     2760

uacaggaugg cacaaccugc ccacgcuuca gaugaaaucu augagauuau gcagaagugu     2820

ugggaggaaa aauuugagau ccgaccaccc uucagccagc uagugcuccu guuggaacgc     2880

cuguuaggag agggcuacaa gaaaaaguau caacaggucg acgaagaguu ccuccggagu     2940

gaucacccug ccauacugag aucucaggca aggcuuccgg guuuucaugg gcugcguucc     3000

ccauuggaca caagcucggu gcucuacacu gcuguacagc ccaacgaggg cgauaacgac     3060

uauauuaucc cucugccaga ucccaagccu gaaguggccg acgagggacc gcuagaaggc     3120

ucacccucuc uggcgaguuc cacccuuaau gaggucaaca caagcucuac uauuagcugc     3180

gauuccccac ucgaaccuca agacgagccc gagccagaac cucagcugga guugcagguu     3240

gaacccgagc cagagcugga acaguuaccg gauucagggu guccugcucc ccgcgccgag     3300

gcagaagaca guuuccucug a                                               3321


<210>  3112
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PGFRB__Homo_sapiens__AAA60049

<400>  3112
augagacugc ccggcgccau gcccgcccug gcccugaagg gcgagcugcu gcugcugagc       60

cugcugcugc ugcuggagcc ccagaucagc cagggccugg uggugacccc ccccggcccc      120

gagcuggugc ugaacgugag cagcaccuuc gugcugaccu gcagcggcag cgcccccgug      180

gugugggaga gaaugagcca ggagcccccc caggagaugg ccaaggccca ggacggcacc      240

uucagcagcg ugcugacccu gaccaaccug accggccugg acaccggcga guacuucugc      300

acccacaacg acagcagagg ccuggagacc gacgagagaa agagacugua caucuucgug      360

cccgacccca ccgugggcuu ccugcccaac gacgccgagg agcuguucau cuuccugacc      420

gagaucaccg agaucaccau ccccugcaga gugaccgacc cccagcuggu ggugacccug      480

cacgagaaga agggcgacgu ggcccugccc gugcccuacg accaccagag aggcuucagc      540

ggcaucuucg aggacagaag cuacaucugc aagaccacca ucggcgacag agagguggac      600

agcgacgccu acuacgugua cagacugcag gugagcagca ucaacgugag cgugaacgcc      660

gugcagaccg uggugagaca gggcgagaac aucacccuga ugugcaucgu gaucggcaac      720

gaggugguga acuucgagug gaccuacccc agaaaggaga gcggcagacu gguggagccc      780

gugaccgacu uccugcugga caugcccuac cacaucagaa gcauccugca cauccccagc      840

gccgagcugg aggacagcgg caccuacacc ugcaacguga ccgagagcgu gaacgaccac      900

caggacgaga aggccaucaa caucaccgug guggagagcg gcuacgugag acugcugggc      960

gaggugggca cccugcaguu cgccgagcug cacagaagca gaacccugca ggugguguuc     1020

gaggccuacc ccccccccac cgugcugugg uucaaggaca acagaacccu gggcgacagc     1080

agcgccggcg agaucgcccu gagcaccaga aacgugagcg agaccagaua cgugagcgag     1140

cugacccugg ugagagugaa gguggccgag gccggccacu acaccaugag agccuuccac     1200

gaggacgccg aggugcagcu gagcuuccag cugcagauca acgugcccgu gagagugcug     1260

gagcugagcg agagccaccc cgacagcggc gagcagaccg ugagaugcag aggcagaggc     1320

augccccagc ccaacaucau cuggagcgcc ugcagagacc ugaagagaug ccccagagag     1380

cugcccccca cccugcuggg caacagcagc gaggaggaga gccagcugga gaccaacgug     1440

accuacuggg aggaggagca ggaguucgag guggugagca cccugagacu gcagcacgug     1500

gacagacccc ugagcgugag augcacccug agaaacgccg ugggccagga cacccaggag     1560

gugaucgugg ugccccacag ccugcccuuc aagguggugg ugaucagcgc cauccuggcc     1620

cugguggugc ugaccaucau cagccugauc auccugauca ugcuguggca gaagaagccc     1680

agauacgaga ucagauggaa ggugaucgag agcgugagca gcgacggcca cgaguacauc     1740

uacguggacc ccaugcagcu gcccuacgac agcaccuggg agcugcccag agaccagcug     1800

gugcugggca gaacccuggg cagcggcgcc uucggccagg ugguggaggc caccgcccac     1860

ggccugagcc acagccaggc caccaugaag guggccguga agaugcugaa gagcaccgcc     1920

agaagcagcg agaagcaggc ccugaugagc gagcugaaga ucaugagcca ccugggcccc     1980

caccugaacg uggugaaccu gcugggcgcc ugcaccaagg gcggccccau cuacaucauc     2040

accgaguacu gcagauacgg cgaccuggug gacuaccugc acagaaacaa gcacaccuuc     2100

cugcagcacc acagcgacaa gagaagaccc cccagcgccg agcuguacag caacgcccug     2160

cccgugggcc ugccccugcc cagccacgug agccugaccg gcgagagcga cggcggcuac     2220

auggacauga gcaaggacga gagcguggac uacgugccca ugcuggacau gaagggcgac     2280

gugaaguacg ccgacaucga gagcagcaac uacauggccc ccuacgacaa cuacgugccc     2340

agcgcccccg agagaaccug cagagccacc cugaucaacg agagccccgu gcugagcuac     2400

auggaccugg ugggcuucag cuaccaggug gccaacggca uggaguuccu ggccagcaag     2460

aacugcgugc acagagaccu ggccgccaga aacgugcuga ucugcgaggg caagcuggug     2520

aagaucugcg acuucggccu ggccagagac aucaugagag acagcaacua caucagcaag     2580

ggcagcaccu uccugccccu gaaguggaug gcccccgaga gcaucuucaa cagccuguac     2640

accacccuga gcgacgugug gagcuucggc auccugcugu gggagaucuu cacccugggc     2700

ggcacccccu accccgagcu gcccaugaac gagcaguucu acaacgccau caagagaggc     2760

uacagaaugg cccagcccgc ccacgccagc gacgagaucu acgagaucau gcagaagugc     2820

ugggaggaga aguucgagau cagacccccc uucagccagc uggugcugcu gcuggagaga     2880

cugcugggcg agggcuacaa gaagaaguac cagcaggugg acgaggaguu ccugagaagc     2940

gaccaccccg ccauccugag aagccaggcc agacugcccg gcuuccacgg ccugagaagc     3000

ccccuggaca ccagcagcgu gcuguacacc gccgugcagc ccaacgaggg cgacaacgac     3060

uacaucaucc cccugcccga ccccaagccc gagguggccg acgagggccc ccuggagggc     3120

agccccagcc uggccagcag cacccugaac gaggugaaca ccagcagcac caucagcugc     3180

gacagccccc uggagcccca ggacgagccc gagcccgagc cccagcugga gcugcaggug     3240

gagcccgagc ccgagcugga gcagcugccc gacagcggcu gccccgcccc cagagccgag     3300

gccgaggaca gcuuccugug a                                               3321


<210>  3113
<211>  3321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PGFRB__Homo_sapiens__AAA60049

<400>  3113
augagacugc ccggcgccau gccugcucuc gcccugaagg gggagcuucu gcuccugagc       60

cuucugcucc ugcuggaacc gcagaucucc caaggacucg uggucacacc cccuggcccc      120

gagcugguuc uuaacguguc uagcaccuuc gugcugacgu gcuccggguc ugcgccuguc      180

gugugggaac ggaugagcca ggagcccccu caggaaaugg cuaaagccca ggacggaacc      240

uuuuccucug uucucacacu gaccaaucuu acaggccugg auaccgggga guacuucugu      300

acacacaacg acagccgcgg acucgagacc gaugaaagaa agcggcugua uauuuuugug      360

ccggacccca cggucggcuu ccugccuaau gaugccgagg aacucuuuau cuuccugacc      420

gagauuacag agaucaccau ucccugccgc gugacagacc cucaacuugu ugugacccug      480

caugaaaaga agggcgaugu cgcucucccc gugccguacg accaccagag aggguuuucc      540

ggaaucuucg aggaucggag cuauaucugu aaaacgacaa uuggcgaccg cgaaguggau      600

ucugacgccu acuaugucua cagacugcag guuuccagca ucaacguguc ugugaaugcu      660

guccagaccg ugguucggca aggggagaac auuacacuua ugugcaucgu gauuggaaau      720

gaagucguga acuuugagug gaccuauccu cgcaaggagu ccggcagacu gguugaaccc      780

gugaccgauu uccuccugga caugccuuac cauauccgga gcauucugca cauccccucu      840

gccgagcucg aagacuccgg gacauacacg uguaauguca ccgagagcgu gaacgaucau      900

caggacgaaa aggcgaucaa uauuacaguc guggaguccg gauauguucg ccugcuuggc      960

gaggugggca cccugcaguu ugccgaacuc cacagaucuc ggacacugca ggucguguuc     1020

gaggcuuauc ccccuccgac cguucuuugg uuuaaagaua accgcacgcu gggggacagc     1080

uccgccggag aaaucgcucu cagcacaaga aaugugucug agacccggua cgucuccgaa     1140

cugacccugg ugagagugaa gguugccgag gcgggccacu acacaaugcg cgccuuccau     1200

gaggaugcug aaguccaacu cagcuuccag cugcagauua acgugcccgu gcggguccuu     1260

gagcugucug aaagccaccc ugacuccggg gagcaaaccg ugagaugccg cggacggggc     1320

augccccagc cuaauaucau uuggucugcc uguagagauc ucaaacgcug cccccgggag     1380

cugccgccua cacugcuugg gaacagcucc gaagaggaaa gccagcucga gacgaacguu     1440

accuauuggg aagaggagca ggaauuugag guggucucua cacugagacu gcaacaugug     1500

gaccgccccc ucuccguucg guguacccug agaaaugcug ugggacagga uacacaggaa     1560

gucaucgugg uuccucacag ccuucccuuc aagguggucg ugaucucugc cauucuggcc     1620

cucguggucc ugaccaucau uucccugauc auucuuauca ugcucuggca gaaaaagccu     1680

cgcuacgaga uccgguggaa gguuauugaa agcguguccu cugacggcca cgaguauauc     1740

uacguggauc ccaugcaacu gccguacgac agcacguggg agcugccuag agaccagcuc     1800

guccugggcc ggacccuugg guccggagcu uuuggccagg ugguugaagc gacagcccau     1860

gggcugucuc acagccaggc uaccaugaaa guggccguca agaugcucaa auccacagcc     1920

cgcagcucug agaagcaagc ucugaugucc gaacugaaaa uuaugagcca ucuuggaccc     1980

caccucaacg ugguuaaucu gcugggcgcc ugcaccaaag ggggccccau cuauauuauc     2040

acggaguacu guagauaugg agaucucgug gacuaccugc aucggaacaa acacacauuc     2100

cuucagcacc auucugauaa gagacgcccu ccguccgcgg aacuguauag caaugcucuc     2160

cccgucggcc ugccucugcc cucucacgug agccuuaccg gggaguccga cggaggcuac     2220

auggauauga gcaaggacga gucuguugau uaugugccua ugcucgacau gaaaggggau     2280

gucaaguacg ccgacauuga auccagcaac uacauggccc ccuaugauaa uuacgugccu     2340

uccgcucccg agcggacaug cagagccacc cugaucaacg aaucuccggu gcugagcuau     2400

auggaccucg ucggauuuuc cuaccagguu gcuaauggca uggaguuccu ggccucuaaa     2460

aacugcgugc aucgcgaucu ugcggccaga aaugugcuga ucugugaggg gaagcucguc     2520

aaaauuugcg acuuuggccu ggcucgggac aucaugcgcg auagcaacua uauuuccaag     2580

ggaucuaccu uccugccucu uaaguggaug gcccccgaaa gcaucuuuaa uucccuguac     2640

acaacgcuca gcgacgugug gucuuucggc auucugcucu gggagaucuu uacccuuggg     2700

ggaacaccuu aucccgaacu gccgaugaac gagcaguucu acaaugcuau caaaagaggc     2760

uaccggaugg cccaaccugc gcacgccucc gaugaaauuu augagaucau gcagaagugu     2820

ugggaggaaa aauuugagau uagacccccu uucagccagc ugguucuccu gcuggaacgc     2880

cuucuggggg agggauacaa gaaaaaguau caacaggugg acgaagaguu ccuccggucu     2940

gaucaccccg cuauccugcg cucccaggcc agacuccccg gcuuucaugg gcugcggagc     3000

ccucuugaca ccucuuccgu ccuguacaca gcugugcagc cgaacgaggg cgauaacgac     3060

uauauuaucc cccucccuga ucccaagccu gaaguugccg acgagggacc ccuggaaggc     3120

agcccuuccc uggccagcuc uacccuuaau gaggugaaca cgagcuccac aaucucuugc     3180

gauagcccgc uggaacccca agacgagccu gagcccgaac cucagcucga gcugcagguc     3240

gaacccgagc cggagcucga acagcugccu gauuccgggu gucccgcucc ccgcgcggag     3300

gccgaagacu cuuuccuuug a                                               3321


<210>  3114
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pim-1_-Kinase__Homo_sapiens__A0A024RD25

<400>  3114

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
1               5                   10                  15      


Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
            20                  25                  30          


Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
        35                  40                  45              


Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
    50                  55                  60                  


Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
65                  70                  75                  80  


Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                85                  90                  95      


Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
            100                 105                 110         


Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
        115                 120                 125             


Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
    130                 135                 140                 


Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
145                 150                 155                 160 


Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                165                 170                 175     


Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
            180                 185                 190         


Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
        195                 200                 205             


Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
    210                 215                 220                 


Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
225                 230                 235                 240 


Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                245                 250                 255     


Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
            260                 265                 270         


Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
        275                 280                 285             


Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
    290                 295                 300                 


His Ser Leu Ser Pro Gly Pro Ser Lys 
305                 310             


<210>  3115
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3115
augcucuugu ccaaaaucaa cucgcuugcc caccugcgcg ccgcgcccug caacgaccug       60

cacgccacca agcuggcgcc cggcaaggag aaggagcccc uggagucgca guaccaggug      120

ggcccgcuac ugggcagcgg cggcuucggc ucggucuacu caggcauccg cgucuccgac      180

aacuugccgg uggccaucaa acacguggag aaggaccgga uuuccgacug gggagagcug      240

ccuaauggca cucgagugcc cauggaagug guccugcuga agaaggugag cucggguuuc      300

uccggcguca uuaggcuccu ggacugguuc gagaggcccg acaguuucgu ccugauccug      360

gagaggcccg agccggugca agaucucuuc gacuucauca cggaaagggg agcccugcaa      420

gaggagcugg cccgcagcuu cuucuggcag gugcuggagg ccgugcggca cugccacaac      480

ugcggggugc uccaccgcga caucaaggac gaaaacaucc uuaucgaccu caaucgcggc      540

gagcucaagc ucaucgacuu cgggucgggg gcgcugcuca aggacaccgu cuacacggac      600

uucgauggga cccgagugua uagcccucca gaguggaucc gcuaccaucg cuaccauggc      660

aggucggcgg cagucugguc ccuggggauc cugcuguaug auauggugug uggagauauu      720

ccuuucgagc augacgaaga gaucaucagg ggccagguuu ucuucaggca gagggucucu      780

ucagaauguc agcaucucau uagauggugc uuggcccuga gaccaucaga uaggccaacc      840

uucgaagaaa uccagaacca uccauggaug caagauguuc uccugcccca ggaaacugcu      900

gagauccacc uccacagccu gucgccgggg cccagcaaau ag                         942


<210>  3116
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3116
augcugcuca gcaagaucaa cucccuggcc caccuccgcg ccgcgcccug caacgaccug       60

cacgccacca agcuggcccc gggcaaggag aaggagcccc uggagagcca guaccaggug      120

gggccccucc ugggcuccgg gggcuucggg agcgucuacu ccggcauccg ggugagcgac      180

aaccugcccg uggccaucaa gcacgucgag aaggaccgca ucuccgacug gggcgagcuc      240

ccgaacggga cccgggugcc cauggaggug guccugcuga agaaggugag cuccggcuuc      300

agcgggguga uccgccuccu ggacugguuc gagcggcccg acuccuucgu ccugauccuc      360

gagcgccccg agccggugca ggaccuguuc gacuucauca cggagcgggg cgcccugcag      420

gaggagcucg cgcgcagcuu cuucuggcag guccuggagg ccgugcggca cugccacaac      480

ugcggggugc ugcaccgcga caucaaggac gagaacaucc ucaucgaccu gaaccggggc      540

gagcugaagc ucaucgacuu cggcuccggg gcccugcuga aggacaccgu guacaccgac      600

uucgacggca cccgcgucua cagcccgccc gaguggaucc gguaccaccg cuaccacggg      660

cgguccgccg cgguguggag ccucggcauc cugcuguacg acauggugug cggcgacauc      720

cccuucgagc acgacgagga gaucauccgc gggcaggucu ucuuccggca gcgcgugucc      780

agcgagugcc agcaccucau ccgguggugc cuggcccugc gccccuccga ccggcccacg      840

uucgaggaga uccagaacca ccccuggaug caggacgugc uccugcccca ggagaccgcc      900

gagauccacc uccacagccu gagcccgggc cccuccaagu ga                         942


<210>  3117
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3117
augcuccucu ccaagaucaa cucccucgcc caccuccgcg ccgcccccug caacgaccuc       60

cacgccacca agcucgcccc cggcaaggag aaggagcccc ucgaguccca guaccagguc      120

ggcccccucc ucggcuccgg cggcuucggc uccgucuacu ccggcauccg cgucuccgac      180

aaccuccccg ucgccaucaa gcacgucgag aaggaccgca ucuccgacug gggcgagcuc      240

cccaacggca cccgcguccc cauggagguc guccuccuca agaaggucuc cuccggcuuc      300

uccggcguca uccgccuccu cgacugguuc gagcgccccg acuccuucgu ccucauccuc      360

gagcgccccg agcccgucca ggaccucuuc gacuucauca ccgagcgcgg cgcccuccag      420

gaggagcucg cccgcuccuu cuucuggcag guccucgagg ccguccgcca cugccacaac      480

ugcggcgucc uccaccgcga caucaaggac gagaacaucc ucaucgaccu caaccgcggc      540

gagcucaagc ucaucgacuu cggcuccggc gcccuccuca aggacaccgu cuacaccgac      600

uucgacggca cccgcgucua cucccccccc gaguggaucc gcuaccaccg cuaccacggc      660

cgcuccgccg ccgucugguc ccucggcauc cuccucuacg acauggucug cggcgacauc      720

cccuucgagc acgacgagga gaucauccgc ggccaggucu ucuuccgcca gcgcgucucc      780

uccgagugcc agcaccucau ccgcuggugc cucgcccucc gccccuccga ccgccccacc      840

uucgaggaga uccagaacca ccccuggaug caggacgucc uccuccccca ggagaccgcc      900

gagauccacc uccacucccu cucccccggc cccuccaagu ga                         942


<210>  3118
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3118
augcugcuca gcaagaucaa cucccuugcc caccugagag cugcacccug caaugacuug       60

caugccacca aauuagcgcc uggcaaggag aaagaaccac uggagucuca guaccaagug      120

gggccgcuac ucggaucagg uggcuucggg agugucuaua gcggaauuag gguuuccgau      180

aaccugcccg uggcuauaaa gcacguagaa aaagaccgga ucucugauug gggcgagcuu      240

ccuaauggua cacgcgugcc aauggaaguc gugcuguuga agaagguuuc gucaggguuu      300

agcggaguga uucgacuccu ggacugguuc gagcgucccg auaguuuugu ccugauccuc      360

gagagaccug aaccagugca ggacuuauuc gauuuuauua cugagagggg cgcccugcag      420

gaggaacuug cacgguccuu cuuuuggcag guauuggagg ccguucgcca uugucacaac      480

ugcggcgugc ugcauagaga caucaaagau gaaaauauac uaaucgaccu caacagggga      540

gagcugaaac uuauugauuu cggaucuggu gcucuguuga aggacacggu cuacaccgau      600

uuugacggca cacgggugua uagcccuccc gaauggaucc gcuaccaccg auaucacggg      660

agauccgcag ccgugugguc acucgggauu cuguuauacg acauggucug uggcgauauc      720

ccauucgagc augacgaaga gauaauuagg ggucaagugu uuuuccggca gcguguuagu      780

agcgagugcc agcaccugau ccgcuggugu cucgcucuua gaccgucuga uaggcccacu      840

uuugaagaga uucagaauca uccuuggaug caagacguac uguugccaca ggaaaccgcc      900

gagauccacc uacacucccu gucacccggg ccuagcaagu ga                         942


<210>  3119
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3119
augcugcuga gcaagaucaa cagccuggcc caccugagag ccgcccccug caacgaccug       60

cacgccacca agcuggcccc cggcaaggag aaggagcccc uggagagcca guaccaggug      120

ggcccccugc ugggcagcgg cggcuucggc agcguguaca gcggcaucag agugagcgac      180

aaccugcccg uggccaucaa gcacguggag aaggacagaa ucagcgacug gggcgagcug      240

cccaacggca ccagagugcc cauggaggug gugcugcuga agaaggugag cagcggcuuc      300

agcggcguga ucagacugcu ggacugguuc gagagacccg acagcuucgu gcugauccug      360

gagagacccg agcccgugca ggaccuguuc gacuucauca ccgagagagg cgcccugcag      420

gaggagcugg ccagaagcuu cuucuggcag gugcuggagg ccgugagaca cugccacaac      480

ugcggcgugc ugcacagaga caucaaggac gagaacaucc ugaucgaccu gaacagaggc      540

gagcugaagc ugaucgacuu cggcagcggc gcccugcuga aggacaccgu guacaccgac      600

uucgacggca ccagagugua cagccccccc gaguggauca gauaccacag auaccacggc      660

agaagcgccg ccguguggag ccugggcauc cugcuguacg acauggugug cggcgacauc      720

cccuucgagc acgacgagga gaucaucaga ggccaggugu ucuucagaca gagagugagc      780

agcgagugcc agcaccugau cagauggugc cuggcccuga gacccagcga cagacccacc      840

uucgaggaga uccagaacca ccccuggaug caggacgugc ugcugcccca ggagaccgcc      900

gagauccacc ugcacagccu gagccccggc cccagcaagu ga                         942


<210>  3120
<211>  942
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Pim-1_-Kinase__Homo_sapiens__EAX03935

<400>  3120
augcugcuca gcaagaucaa cucccuggcc caccuuagag cugcccccug caaugaccug       60

caugcgacca aacucgcucc uggcaaggag aaagaaccgc uggagucuca guaccaagug      120

gggccccuuc ugggaagcgg cggguucgga uccgucuauu cuggcauucg gguuagcgau      180

aaccucccug uggccaucaa gcacguggaa aaagaccgca uuuccgauug gggagagcug      240

cccaauggaa caagaguccc uauggaagug guucugcuca agaagguguc uagcggcuuu      300

uccggcguca uccggcugcu ugacugguuc gagcgccccg auagcuuugu gcugauucuc      360

gagagaccug aaccgguuca ggaccuguuc gauuuuauca cggagcgcgg ggcccuucag      420

gaggaacugg cucggucuuu cuuuuggcaa gugcucgagg ccgucagaca uugucacaac      480

ugcggagugc ugcaucggga caucaaagau gaaaauauuc ugaucgaccu caaccgcggc      540

gagcugaaac uuauugauuu cggguccgga gcucugcuca aggacaccgu guacacagau      600

uuugacggca ccagagucua uucucccccu gaauggaucc gguaccaccg cuaucacggg      660

agaagcgccg cgguuugguc ccuggggauu cuucuguacg acauggugug uggcgauauc      720

cccuucgagc augacgaaga gauuauccgg ggccaggugu uuuuccgcca gagagucagc      780

ucugagugcc agcaccucau ccgguggugu cuggcccuga gaccuuccga ucgccccaca      840

uuugaagaga uucagaauca uccguggaug caagacgugc uccugccuca ggaaaccgcu      900

gagauccacc uucacagccu gucccccggg ccuucuaagu ga                         942


<210>  3121
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__O15428

<400>  3121

Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser 
1               5                   10                  15      


Arg Pro Ser Gly Arg Gly Tyr Tyr Phe Asn His Ile Thr Asn Pro Ser 
            20                  25                  30          


Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Ile Trp 
        35                  40                  45              


Gln Gly Glu Pro Ala Arg Val Arg Arg Ser His Leu Leu Val Lys Pro 
    50                  55                  60                  


Val Lys Ala Ala Leu Asp Leu Ala Ala Gly Asn His Pro Asp Gln Gly 
65                  70                  75                  80  


Gly Gly Pro Gly Ala Asp Gln Arg Leu His Pro Glu Asp Gln Gly Arg 
                85                  90                  95      


Arg Glu Gly Leu 
            100 


<210>  3122
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__AAB81333

<400>  3122
auggcggacg aggagaaacu gccgccuggc ugggaaaagc gcaugagccg ccccucaggc       60

cgaggguacu acuucaacca caucacuaac cccagccagu gggagcggcc cagcgggaac      120

agcagcagug gcggcaaaau cuggcagggg gagcccgcca ggguccgccg cucgcaccug      180

cuagugaagc cagucaaggc ggcccucgac cuggcggcag gaaaucaccc ggaccaagga      240

ggaggcccug gagcugauca gcggcuacau ccagaagauc aaggcaggag agaaggacuu      300

uga                                                                    303


<210>  3123
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Pin-1__Homo_sapiens__AAB81333

<400>  3123
auggccgacg aggagaagcu gcccccgggc ugggagaagc gcaugagccg gcccuccggg       60

cgcggcuacu acuucaacca caucaccaac cccagccagu gggagcggcc cuccgggaac      120

agcuccagcg gcgggaagau cuggcagggc gagccggccc gcgugcggcg cucccaccuc      180

cuggucaagc ccgugaaggc ggcccuggac cucgccgccg gcaaccaccc cgaccagggc      240

ggcgggcccg gggccgacca gcggcugcac ccggaggacc aggggcgccg ggagggccug      300

uga                                                                    303


<210>  3124
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Pin-1__Homo_sapiens__AAB81333

<400>  3124
auggccgacg aggagaagcu cccccccggc ugggagaagc gcaugucccg ccccuccggc       60

cgcggcuacu acuucaacca caucaccaac cccucccagu gggagcgccc cuccggcaac      120

uccuccuccg gcggcaagau cuggcagggc gagcccgccc gcguccgccg cucccaccuc      180

cucgucaagc ccgucaaggc cgcccucgac cucgccgccg gcaaccaccc cgaccagggc      240

ggcggccccg gcgccgacca gcgccuccac cccgaggacc agggccgccg cgagggccuc      300

uga                                                                    303


<210>  3125
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Pin-1__Homo_sapiens__AAB81333

<400>  3125
auggccgacg aggaaaagcu gcccccuggc ugggagaaaa gaaugagcag gccauccggg       60

cggggauacu auuucaacca caucaccaau ccgucucagu gggaacgccc cucagguaac      120

aguagcuccg gcgggaagau uuggcaagga gagccugcuc gagugcguag aucucaucuc      180

cuugucaaac caguuaaggc agcccuggau uuggcggcug gcaaucaccc cgaccagggu      240

gggggaccug gcgccgauca gagguuacau ccagaagacc agggccggcg cgaggggcug      300

uga                                                                    303


<210>  3126
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Pin-1__Homo_sapiens__AAB81333

<400>  3126
auggccgacg aggagaagcu gccccccggc ugggagaaga gaaugagcag acccagcggc       60

agaggcuacu acuucaacca caucaccaac cccagccagu gggagagacc cagcggcaac      120

agcagcagcg gcggcaagau cuggcagggc gagcccgcca gagugagaag aagccaccug      180

cuggugaagc ccgugaaggc cgcccuggac cuggccgccg gcaaccaccc cgaccagggc      240

ggcggccccg gcgccgacca gagacugcac cccgaggacc agggcagaag agagggccug      300

uga                                                                    303


<210>  3127
<211>  303
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Pin-1__Homo_sapiens__AAB81333

<400>  3127
auggccgacg aggaaaagcu gcccccuggc ugggagaaaa gaaugagccg gccguccggg       60

cgcggauacu auuucaacca caucaccaau cccucucagu gggaaagacc uagcggcaac      120

uccucuagcg ggggaaagau uuggcaaggc gagcccgcuc gggugcgcag aucccaucuc      180

cuggucaaac cuguuaaggc cgcgcuugau cuggcugccg ggaaucaccc cgaccaggga      240

ggcggcccug gggccgauca gcggcuccau ccggaagacc agggacgcag agagggccug      300

uga                                                                    303


<210>  3128
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__Q13526

<400>  3128

Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser 
1               5                   10                  15      


Arg Ser Ser Gly Arg Val Tyr Tyr Phe Asn His Ile Thr Asn Ala Ser 
            20                  25                  30          


Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Asn Gly 
        35                  40                  45              


Gln Gly Glu Pro Ala Arg Val Arg Cys Ser His Leu Leu Val Lys His 
    50                  55                  60                  


Ser Gln Ser Arg Arg Pro Ser Ser Trp Arg Gln Glu Lys Ile Thr Arg 
65                  70                  75                  80  


Thr Lys Glu Glu Ala Leu Glu Leu Ile Asn Gly Tyr Ile Gln Lys Ile 
                85                  90                  95      


Lys Ser Gly Glu Glu Asp Phe Glu Ser Leu Ala Ser Gln Phe Ser Asp 
            100                 105                 110         


Cys Ser Ser Ala Lys Ala Arg Gly Asp Leu Gly Ala Phe Ser Arg Gly 
        115                 120                 125             


Gln Met Gln Lys Pro Phe Glu Asp Ala Ser Phe Ala Leu Arg Thr Gly 
    130                 135                 140                 


Glu Met Ser Gly Pro Val Phe Thr Asp Ser Gly Ile His Ile Ile Leu 
145                 150                 155                 160 


Arg Thr Glu 
            


<210>  3129
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__AAC50492

<400>  3129
auggcggacg aggagaagcu gccgcccggc ugggagaagc gcaugagccg cagcucaggc       60

cgaguguacu acuucaacca caucacuaac gccagccagu gggagcggcc cagcggcaac      120

agcagcagug guggcaaaaa cgggcagggg gagccugcca ggguccgcug cucgcaccug      180

cuggugaagc acagccaguc acggcggccc ucguccuggc ggcaggagaa gaucacccgg      240

accaaggagg aggcccugga gcugaucaac ggcuacaucc agaagaucaa gucgggagag      300

gaggacuuug agucucuggc cucacaguuc agcgacugca gcucagccaa ggccagggga      360

gaccugggug ccuucagcag aggucagaug cagaagccau uugaagacgc cucguuugcg      420

cugcggacgg gggagaugag cgggcccgug uucacggauu ccggcaucca caucauccuc      480

cgcacugagu ga                                                          492


<210>  3130
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Pin-1__Homo_sapiens__AAC50492

<400>  3130
auggccgacg aggagaagcu gcccccgggc ugggagaagc gcaugagccg guccagcggg       60

cgcguguacu acuucaacca caucaccaac gccucccagu gggagcggcc cagcggcaac      120

uccagcuccg ggggcaagaa cgggcagggc gagcccgcgc gcguccggug cagccaccuc      180

cuggugaagc acucccagag ccgccggccc uccagcuggc gccaggagaa gaucacccgg      240

acgaaggagg aggcccugga gcucaucaac ggcuacaucc agaagaucaa guccggggag      300

gaggacuucg agagccuggc cucccaguuc agcgacugcu ccagcgccaa ggcccgcggc      360

gaccuggggg cguucucccg gggccagaug cagaagccgu ucgaggacgc cagcuucgcc      420

cuccgcaccg gggagaugag cggccccgug uucaccgacu ccggcaucca caucauccug      480

cggaccgagu ga                                                          492


<210>  3131
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Pin-1__Homo_sapiens__AAC50492

<400>  3131
auggccgacg aggagaagcu cccccccggc ugggagaagc gcaugucccg cuccuccggc       60

cgcgucuacu acuucaacca caucaccaac gccucccagu gggagcgccc cuccggcaac      120

uccuccuccg gcggcaagaa cggccagggc gagcccgccc gcguccgcug cucccaccuc      180

cucgucaagc acucccaguc ccgccgcccc uccuccuggc gccaggagaa gaucacccgc      240

accaaggagg aggcccucga gcucaucaac ggcuacaucc agaagaucaa guccggcgag      300

gaggacuucg agucccucgc cucccaguuc uccgacugcu ccuccgccaa ggcccgcggc      360

gaccucggcg ccuucucccg cggccagaug cagaagcccu ucgaggacgc cuccuucgcc      420

cuccgcaccg gcgagauguc cggccccguc uucaccgacu ccggcaucca caucauccuc      480

cgcaccgagu ga                                                          492


<210>  3132
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Pin-1__Homo_sapiens__AAC50492

<400>  3132
auggccgacg aggaaaagcu gcccccuggc ugggagaaaa gaaugagcag guccucuggg       60

cggguguacu auuucaacca caucaccaau gcuucacagu gggaacgccc aaguggaaac      120

agcuccucug guggcaagaa ugggcaagga gagccggcac gaguccguug cucgcaucuc      180

cuuguuaaac acucacagag cagaaggccc aguuccuggc ggcaggaaaa gauuacacgc      240

acuaaagagg aggcccugga auugauaaac ggcuacaucc agaagauuaa gucuggugag      300

gaagauuuug agagcuuagc gucccaauuc ucagacugua guagcgcuaa agccagaggg      360

gaucugggag cauuuucuag gggccagaug cagaagccuu ucgaggacgc cuccuuugcu      420

cuacggacgg gcgaaauguc agggccagug uucaccgaua gcggaaucca uauuauccuc      480

cgcacagagu ga                                                          492


<210>  3133
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Pin-1__Homo_sapiens__AAC50492

<400>  3133
auggccgacg aggagaagcu gccccccggc ugggagaaga gaaugagcag aagcagcggc       60

agaguguacu acuucaacca caucaccaac gccagccagu gggagagacc cagcggcaac      120

agcagcagcg gcggcaagaa cggccagggc gagcccgcca gagugagaug cagccaccug      180

cuggugaagc acagccagag cagaagaccc agcagcugga gacaggagaa gaucaccaga      240

accaaggagg aggcccugga gcugaucaac ggcuacaucc agaagaucaa gagcggcgag      300

gaggacuucg agagccuggc cagccaguuc agcgacugca gcagcgccaa ggccagaggc      360

gaccugggcg ccuucagcag aggccagaug cagaagcccu ucgaggacgc cagcuucgcc      420

cugagaaccg gcgagaugag cggccccgug uucaccgaca gcggcaucca caucauccug      480

agaaccgagu ga                                                          492


<210>  3134
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Pin-1__Homo_sapiens__AAC50492

<400>  3134
auggccgacg aggaaaagcu gcccccuggc ugggagaaaa gaaugagccg guccucuggg       60

cgcguguacu auuucaacca caucaccaau gcuagccagu gggaaagacc guccggaaac      120

ucuagcuccg gcgggaagaa uggacaaggc gagcccgccc ggguccgcug cucucaucuc      180

cugguuaaac acagccaguc cagacggccu agcucuuggc gccaggaaaa gauuacaaga      240

acgaaagagg aggcgcuuga acugaucaac ggguacauuc agaagaucaa guccggagag      300

gaagauuuug agagccucgc uucucaauuc uccgacugua gcucugccaa agcccggggc      360

gaucugggcg cuuuuucccg cgggcagaug cagaagcccu ucgaggacgc cagcuuugcu      420

cuuagaaccg gagaaauguc cggcccugug uucacagauu cugggauuca uaucauccug      480

cggaccgagu ga                                                          492


<210>  3135
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__Q49AR7

<400>  3135

Met Gln Lys Pro Phe Glu Asp Ala Ser Phe Ala Leu Arg Thr Gly Glu 
1               5                   10                  15      


Met Ser Gly Pro Val Phe Thr Asp Ser Gly Ile His Ile Ile Leu Arg 
            20                  25                  30          


Thr Glu Cys Trp Arg Gln Thr Arg Gly Pro Asn Cys Phe 
        35                  40                  45  


<210>  3136
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Pin-1__Homo_sapiens__AAH31971

<400>  3136
augcagaagc cauuugaaga cgccucguuu gcgcugcgga cgggggagau gagcgggccc       60

guguucacgg auuccggcau ccacaucauc cuccgcacug agugcuggag gcagacucga      120

gggccgaauu guuucuag                                                    138


<210>  3137
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Pin-1__Homo_sapiens__AAH31971

<400>  3137
augcagaagc ccuucgagga cgccagcuuc gcccugcgca ccggcgagau guccgggccg       60

guguucaccg acagcggcau ccacaucauc cuccggacgg agugcuggcg ccagacccgg      120

gggcccaacu gcuucuga                                                    138


<210>  3138
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Pin-1__Homo_sapiens__AAH31971

<400>  3138
augcagaagc ccuucgagga cgccuccuuc gcccuccgca ccggcgagau guccggcccc       60

gucuucaccg acuccggcau ccacaucauc cuccgcaccg agugcuggcg ccagacccgc      120

ggccccaacu gcuucuga                                                    138


<210>  3139
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Pin-1__Homo_sapiens__AAH31971

<400>  3139
augcagaagc ccuucgagga cgccagcuuu gcucugagaa ccggcgaaau guccgggccu       60

guguucacag auucuggaau ccacauuaua cucaggacug agugcuggcg gcaaacgcgc      120

gguccaaacu guuuuuga                                                    138


<210>  3140
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Pin-1__Homo_sapiens__AAH31971

<400>  3140
augcagaagc ccuucgagga cgccagcuuc gcccugagaa ccggcgagau gagcggcccc       60

guguucaccg acagcggcau ccacaucauc cugagaaccg agugcuggag acagaccaga      120

ggccccaacu gcuucuga                                                    138


<210>  3141
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Pin-1__Homo_sapiens__AAH31971

<400>  3141
augcagaagc ccuucgagga cgccagcuuu gcucugagaa ccggcgaaau guccgggccu       60

guguucacag auucuggaau ccacauuauc cuccggacgg agugcuggcg ccaaaccaga      120

ggcccgaacu guuuuuga                                                    138


<210>  3142
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PLAC1__Homo_sapiens__Q9HBJ0

<400>  3142

Met Lys Val Phe Lys Phe Ile Gly Leu Met Ile Leu Leu Thr Ser Ala 
1               5                   10                  15      


Phe Ser Ala Gly Ser Gly Gln Ser Pro Met Thr Val Leu Cys Ser Ile 
            20                  25                  30          


Asp Trp Phe Met Val Thr Val His Pro Phe Met Leu Asn Asn Asp Val 
        35                  40                  45              


Cys Val His Phe His Glu Leu His Leu Gly Leu Gly Cys Pro Pro Asn 
    50                  55                  60                  


His Val Gln Pro His Ala Tyr Gln Phe Thr Tyr Arg Val Thr Glu Cys 
65                  70                  75                  80  


Gly Ile Arg Ala Lys Ala Val Ser Gln Asp Met Val Ile Tyr Ser Thr 
                85                  90                  95      


Glu Ile His Tyr Ser Ser Lys Gly Thr Pro Ser Lys Phe Val Ile Pro 
            100                 105                 110         


Val Ser Cys Ala Ala Pro Gln Lys Ser Pro Trp Leu Thr Lys Pro Cys 
        115                 120                 125             


Ser Met Arg Val Ala Ser Lys Ser Arg Ala Thr Ala Gln Lys Asp Glu 
    130                 135                 140                 


Lys Cys Tyr Glu Val Phe Ser Leu Ser Gln Ser Ser Gln Arg Pro Asn 
145                 150                 155                 160 


Cys Asp Cys Pro Pro Cys Val Phe Ser Glu Glu Glu His Thr Gln Val 
                165                 170                 175     


Pro Cys His Gln Ala Gly Ala Gln Glu Ala Gln Pro Leu Gln Pro Ser 
            180                 185                 190         


His Phe Leu Asp Ile Ser Glu Asp Trp Ser Leu His Thr Asp Asp Met 
        195                 200                 205             


Ile Gly Ser Met 
    210         


<210>  3143
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PLAC1__Homo_sapiens__AAG22596

<400>  3143
augaaaguuu uuaaguucau aggacugaug auccuccuca ccucugcguu uucagccggu       60

ucaggacaaa guccaaugac ugugcugugc uccauagacu gguucauggu cacagugcac      120

cccuucaugc uaaacaacga ugugugugua cacuuucaug aacuacacuu gggccugggu      180

ugccccccaa accauguuca gccacacgcc uaccaguuca ccuaccgugu uacugaaugu      240

ggcaucaggg ccaaagcugu cucucaggac augguuaucu acagcacuga gauacacuac      300

ucuucuaagg gcacgccauc uaaguuugug aucccagugu caugugcugc cccccaaaag      360

uccccauggc ucaccaagcc cugcuccaug agaguagcca gcaagagcag ggccacagcc      420

cagaaggaug agaaaugcua cgagguguuc agcuugucac aguccaguca aaggcccaac      480

ugcgauuguc caccuugugu cuucagugaa gaagagcaua cccagguccc uugucaccaa      540

gcaggggcuc aggaggcuca accucugcag ccaucucacu uucuugauau uucugaggau      600

uggucucuuc acacagauga uaugauuggg uccauguga                             639


<210>  3144
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PLAC1__Homo_sapiens__AAG22596

<400>  3144
augaaggugu ucaaguucau cggccugaug auccuccuga ccagcgccuu cuccgccggg       60

agcggccagu cccccaugac cguccugugc agcaucgacu gguucauggu gacggugcac      120

ccguucaugc ucaacaacga cgucugcgug cacuuccacg agcugcaccu ggggcucggc      180

ugcccgccca accacgugca gccccacgcg uaccaguuca ccuaccgcgu caccgagugc      240

gggauccggg ccaaggccgu gucccaggac auggugaucu acagcaccga gauccacuac      300

uccagcaagg gcacgcccuc caaguucguc auccccguga gcugcgccgc gccccagaag      360

ucccccuggc ugaccaagcc gugcagcaug cgcguggccu ccaagagccg ggccaccgcc      420

cagaaggacg agaagugcua cgaggucuuc ucccugagcc aguccagcca gcgccccaac      480

ugcgacugcc cgcccugcgu guucuccgag gaggagcaca cccaggugcc cugccaccag      540

gccggcgcgc aggaggccca gccccuccag cccagccacu uccuggacau cagcgaggac      600

uggucccugc acacggacga caugaucggg agcauguga                             639


<210>  3145
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PLAC1__Homo_sapiens__AAG22596

<400>  3145
augaaggucu ucaaguucau cggccucaug auccuccuca ccuccgccuu cuccgccggc       60

uccggccagu cccccaugac cguccucugc uccaucgacu gguucauggu caccguccac      120

cccuucaugc ucaacaacga cgucugcguc cacuuccacg agcuccaccu cggccucggc      180

ugccccccca accacgucca gccccacgcc uaccaguuca ccuaccgcgu caccgagugc      240

ggcauccgcg ccaaggccgu cucccaggac auggucaucu acuccaccga gauccacuac      300

uccuccaagg gcacccccuc caaguucguc auccccgucu ccugcgccgc cccccagaag      360

ucccccuggc ucaccaagcc cugcuccaug cgcgucgccu ccaagucccg cgccaccgcc      420

cagaaggacg agaagugcua cgaggucuuc ucccucuccc aguccuccca gcgccccaac      480

ugcgacugcc cccccugcgu cuucuccgag gaggagcaca cccagguccc cugccaccag      540

gccggcgccc aggaggccca gccccuccag cccucccacu uccucgacau cuccgaggac      600

uggucccucc acaccgacga caugaucggc uccauguga                             639


<210>  3146
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PLAC1__Homo_sapiens__AAG22596

<400>  3146
augaaggugu ucaaauuuau cggccugaug auucuccuua ccagcgccuu cuccgcuggg       60

ucuggacagu cacccaugac aguccugugc aguauagacu gguuuauggu uacugugcac      120

ccuuucaugu ugaacaauga uguaugugug cauuuucacg aguuacaucu gggucuaggc      180

ugcccaccga accacgucca accccaugca uaccaguuca cguauagagu gaccgaaugu      240

gggaucaggg ccaaggcggu uagccaggac auggugauuu acuccacaga gauccacuau      300

ucuucgaaag gaacuccuuc aaaguuuguc auuccaguga gcugcgcugc accccagaaa      360

aguccuuggc ucaccaagcc auguuccaug cggguagccu cuaagagccg cgccacagcu      420

caaaaagaug aaaagugcua cgagguuuuc ucccugucac agaguagcca gcgacccaau      480

ugugacugcc cuccaugugu guuuucugaa gaggagcaca cccagguccc gugccaucaa      540

gcaggcgccc aggaagcuca gccccuucag ccuucccacu uccuggauau cucagaggac      600

uggagcuugc auacugauga caugauaggu aguauguga                             639


<210>  3147
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PLAC1__Homo_sapiens__AAG22596

<400>  3147
augaaggugu ucaaguucau cggccugaug auccugcuga ccagcgccuu cagcgccggc       60

agcggccaga gccccaugac cgugcugugc agcaucgacu gguucauggu gaccgugcac      120

cccuucaugc ugaacaacga cgugugcgug cacuuccacg agcugcaccu gggccugggc      180

ugccccccca accacgugca gccccacgcc uaccaguuca ccuacagagu gaccgagugc      240

ggcaucagag ccaaggccgu gagccaggac auggugaucu acagcaccga gauccacuac      300

agcagcaagg gcacccccag caaguucgug auccccguga gcugcgccgc cccccagaag      360

agccccuggc ugaccaagcc cugcagcaug agaguggcca gcaagagcag agccaccgcc      420

cagaaggacg agaagugcua cgagguguuc agccugagcc agagcagcca gagacccaac      480

ugcgacugcc cccccugcgu guucagcgag gaggagcaca cccaggugcc cugccaccag      540

gccggcgccc aggaggccca gccccugcag cccagccacu uccuggacau cagcgaggac      600

uggagccugc acaccgacga caugaucggc agcauguga                             639


<210>  3148
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PLAC1__Homo_sapiens__AAG22596

<400>  3148
augaaggugu ucaaauuuau cggccugaug auucuccuga ccagcgccuu cuccgcuggg       60

ucuggacaga gccccaugac aguccuuugc uccaucgacu gguuuauggu uacggugcac      120

ccuuucaugc ugaacaauga uguguguguc cauuuucacg agcuccaucu gggccuuggg      180

ugcccgccca accacgugca accucaugcc uaccaguuca ccuauagagu uacagaaugu      240

ggcauucggg cgaaggcugu gucucaggac auggucaucu acagcaccga gauucacuau      300

uccucuaaag gaacacccag caaguuugug aucccuguuu ccugcgccgc uccccagaaa      360

agcccuuggc ugaccaagcc guguucuaug cgcguggccu ccaagagcag agccacagcu      420

caaaaagaug aaaagugcua cgaggucuuc ucucucuccc agagcucuca gcggcccaau      480

ugugacugcc cucccugugu guuuuccgaa gaggagcaca cccaggugcc uugccaucaa      540

gccggggcgc aggaagccca gccccugcag ccgagccacu uccuggauau cuccgaggac      600

uggucucucc auacggauga caugauugga agcauguga                             639


<210>  3149
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PMEL__Homo_sapiens__P40967

<400>  3149

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  3150
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PMEL__Homo_sapiens__AAB00386

<400>  3150
auggaucugg ugcuaaaaag augccuucuu cauuuggcug ugauaggugc uuugcuggcu       60

gugggggcua caaaaguacc cagaaaccag gacuggcuug gugucucaag gcaacucaga      120

accaaagccu ggaacaggca gcuguaucca gaguggacag aagcccagag acuugacugc      180

uggagaggug gucaaguguc ccucaagguc aguaaugaug ggccuacacu gauuggugca      240

aaugccuccu ucucuauugc cuugaacuuc ccuggaagcc aaaagguauu gccagauggg      300

cagguuaucu gggucaacaa uaccaucauc aaugggagcc aggugugggg aggacagcca      360

guguaucccc aggaaacuga cgaugccugc aucuucccug augguggacc uugcccaucu      420

ggcucuuggu cucagaagag aagcuuuguu uaugucugga agaccugggg ccaauacugg      480

caaguucuag ggggcccagu gucugggcug agcauuggga caggcagggc aaugcugggc      540

acacacacca uggaagugac ugucuaccau cgccggggau cccggagcua ugugccucuu      600

gcucauucca gcucagccuu caccauuacu gaccaggugc cuuucuccgu gagcgugucc      660

caguugcggg ccuuggaugg agggaacaag cacuuccuga gaaaucagcc ucugaccuuu      720

gcccuccagc uccaugaccc caguggcuau cuggcugaag cugaccucuc cuacaccugg      780

gacuuuggag acaguagugg aacccugauc ucucgggcac uuguggucac ucauacuuac      840

cuggagccug gcccagucac ugcccaggug guccugcagg cugccauucc ucucaccucc      900

uguggcuccu ccccaguucc aggcaccaca gaugggcaca ggccaacugc agaggccccu      960

aacaccacag cuggccaagu gccuacuaca gaaguugugg guacuacacc uggucaggcg     1020

ccaacugcag agcccucugg aaccacaucu gugcaggugc caaccacuga agucauaagc     1080

acugcaccug ugcagaugcc aacugcagag agcacaggua ugacaccuga gaaggugcca     1140

guuucagagg ucauggguac cacacuggca gagaugucaa cuccagaggc uacagguaug     1200

acaccugcag agguaucaau uguggugcuu ucuggaacca cagcugcaca gguaacaacu     1260

acagaguggg uggagaccac agcuagagag cuaccuaucc cugagccuga agguccagau     1320

gccagcucaa ucaugucuac ggaaaguauu acagguuccc ugggcccccu gcuggauggu     1380

acagccaccu uaaggcuggu gaagagacaa gucccccugg auuguguucu guaucgauau     1440

gguuccuuuu ccgucacccu ggacauuguc caggguauug aaagugccga gauccugcag     1500

gcugugccgu ccggugaggg ggaugcauuu gagcugacug uguccugcca aggcgggcug     1560

cccaaggaag ccugcaugga gaucucaucg ccagggugcc agcccccugc ccagcggcug     1620

ugccagccug ugcuacccag cccagccugc cagcugguuc ugcaccagau acugaagggu     1680

ggcucgggga cauacugccu caaugugucu cuggcugaua ccaacagccu ggcagugguc     1740

agcacccagc uuaucaugcc uggucaagaa gcaggccuug ggcagguucc gcugaucgug     1800

ggcaucuugc ugguguugau ggcugugguc cuugcaucuc ugauauauag gcgcagacuu     1860

augaagcaag acuucuccgu accccaguug ccacauagca gcagucacug gcugcgucua     1920

ccccgcaucu ucugcucuug ucccauuggu gagaauagcc cccuccucag ugggcagcag     1980

gucuga                                                                1986


<210>  3151
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PMEL__Homo_sapiens__AAB00386

<400>  3151
auggaccugg ugcucaagcg cugccugcug caccucgccg ugaucggcgc ccugcuggcg       60

gugggggcca ccaaggugcc ccggaaccag gacuggcucg gcgucagccg ccagcugcgg      120

accaaggccu ggaaccgcca gcuguacccg gaguggacgg aggcccagcg gcucgacugc      180

uggcgcgggg gccagguguc ccugaaggug agcaacgacg ggcccacccu gaucggcgcc      240

aacgcguccu ucagcaucgc ccucaacuuc cccggcuccc agaagguccu gcccgacggc      300

caggugaucu gggugaacaa caccaucauc aacgggagcc aggucugggg cgggcagccg      360

guguaccccc aggagaccga cgacgccugc aucuuccccg acgggggccc cugcccgucc      420

ggcagcuggu cccagaagcg gagcuucgug uacgucugga agacgugggg gcaguacugg      480

cagguccugg gcgggcccgu guccggccuc agcaucggca ccgggcgcgc caugcugggc      540

acccacacca uggaggugac gguguaccac cggcgcgggu cccggagcua cgugccccug      600

gcgcacucca gcuccgccuu caccaucacc gaccaggucc ccuucagcgu guccgugagc      660

cagcuccgcg cccuggacgg cgggaacaag cacuuccugc ggaaccagcc gcucaccuuc      720

gcccugcagc ugcacgaccc cagcggcuac cucgccgagg cggaccuguc cuacacgugg      780

gacuucggcg acagcuccgg gacccugauc agccgcgccc ucgucgugac ccacaccuac      840

cuggagcccg gccccgugac ggcccagguc gugcugcagg ccgccauccc gcucaccucc      900

ugcgggagcu cccccguccc cggcaccacc gacgggcacc ggcccacggc ggaggccccg      960

aacaccaccg ccggccaggu gcccaccacg gagguggucg gcaccacccc cgggcaggcc     1020

cccaccgccg agccgagcgg cacgaccucc guccaggugc ccaccaccga ggugaucagc     1080

acggcgcccg ugcagaugcc caccgccgag uccaccggga ugaccccgga gaaggugccc     1140

gucagcgagg ugaugggcac gacccuggcc gagaugucca cccccgaggc caccgggaug     1200

accccggccg aggugagcau cgucgugcug uccggcacga ccgcggccca ggugaccacc     1260

acggaguggg ucgagaccac cgcccgcgag cuccccaucc ccgagcccga gggcccggac     1320

gccagcucca ucaugagcac cgaguccauc acggggagcc ugggcccccu gcucgacggg     1380

accgcgaccc ugcggcuggu gaagcgccag gugccccucg acugcguccu guaccgguac     1440

ggcagcuucu ccgugacccu ggacaucgug cagggcaucg agagcgccga gauccuccag     1500

gccguccccu ccggggaggg cgacgccuuc gagcugacgg ugagcugcca gggcgggcug     1560

ccgaaggagg ccugcaugga gaucuccagc cccgggugcc agccgcccgc gcagcgccuc     1620

ugccagcccg ugcugcccuc ccccgccugc cagcuggucc uccaccagau ccugaagggc     1680

ggcagcggga ccuacugccu gaacgugucc cuggccgaca ccaacagccu cgccgugguc     1740

uccacccagc ugaucaugcc cggccaggag gccgggcugg gccaggugcc gcucaucgug     1800

gggauccugc ugguccucau ggcgguggug cuggccagcc ugaucuaccg gcgccgccuc     1860

augaagcagg acuucuccgu cccccagcug ccccacagcu ccagccacug gcugcggcuc     1920

ccccgcaucu ucugcuccug cccgaucggc gagaacagcc cccugcugag cggccagcag     1980

gucuga                                                                1986


<210>  3152
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PMEL__Homo_sapiens__AAB00386

<400>  3152
auggaccucg uccucaagcg cugccuccuc caccucgccg ucaucggcgc ccuccucgcc       60

gucggcgcca ccaagguccc ccgcaaccag gacuggcucg gcgucucccg ccagcuccgc      120

accaaggccu ggaaccgcca gcucuacccc gaguggaccg aggcccagcg ccucgacugc      180

uggcgcggcg gccaggucuc ccucaagguc uccaacgacg gccccacccu caucggcgcc      240

aacgccuccu ucuccaucgc ccucaacuuc cccggcuccc agaagguccu ccccgacggc      300

caggucaucu gggucaacaa caccaucauc aacggcuccc aggucugggg cggccagccc      360

gucuaccccc aggagaccga cgacgccugc aucuuccccg acggcggccc cugccccucc      420

ggcuccuggu cccagaagcg cuccuucguc uacgucugga agaccugggg ccaguacugg      480

cagguccucg gcggccccgu cuccggccuc uccaucggca ccggccgcgc caugcucggc      540

acccacacca uggaggucac cgucuaccac cgccgcggcu cccgcuccua cgucccccuc      600

gcccacuccu ccuccgccuu caccaucacc gaccaggucc ccuucuccgu cuccgucucc      660

cagcuccgcg cccucgacgg cggcaacaag cacuuccucc gcaaccagcc ccucaccuuc      720

gcccuccagc uccacgaccc cuccggcuac cucgccgagg ccgaccucuc cuacaccugg      780

gacuucggcg acuccuccgg cacccucauc ucccgcgccc ucgucgucac ccacaccuac      840

cucgagcccg gccccgucac cgcccagguc guccuccagg ccgccauccc ccucaccucc      900

ugcggcuccu cccccguccc cggcaccacc gacggccacc gccccaccgc cgaggccccc      960

aacaccaccg ccggccaggu ccccaccacc gaggucgucg gcaccacccc cggccaggcc     1020

cccaccgccg agcccuccgg caccaccucc guccaggucc ccaccaccga ggucaucucc     1080

accgcccccg uccagaugcc caccgccgag uccaccggca ugacccccga gaaggucccc     1140

gucuccgagg ucaugggcac cacccucgcc gagaugucca cccccgaggc caccggcaug     1200

acccccgccg aggucuccau cgucguccuc uccggcacca ccgccgccca ggucaccacc     1260

accgaguggg ucgagaccac cgcccgcgag cuccccaucc ccgagcccga gggccccgac     1320

gccuccucca ucauguccac cgaguccauc accggcuccc ucggcccccu ccucgacggc     1380

accgccaccc uccgccucgu caagcgccag gucccccucg acugcguccu cuaccgcuac     1440

ggcuccuucu ccgucacccu cgacaucguc cagggcaucg aguccgccga gauccuccag     1500

gccguccccu ccggcgaggg cgacgccuuc gagcucaccg ucuccugcca gggcggccuc     1560

cccaaggagg ccugcaugga gaucuccucc cccggcugcc agccccccgc ccagcgccuc     1620

ugccagcccg uccuccccuc ccccgccugc cagcucgucc uccaccagau ccucaagggc     1680

ggcuccggca ccuacugccu caacgucucc cucgccgaca ccaacucccu cgccgucguc     1740

uccacccagc ucaucaugcc cggccaggag gccggccucg gccagguccc ccucaucguc     1800

ggcauccucc ucguccucau ggccgucguc cucgccuccc ucaucuaccg ccgccgccuc     1860

augaagcagg acuucuccgu cccccagcuc ccccacuccu ccucccacug gcuccgccuc     1920

ccccgcaucu ucugcuccug ccccaucggc gagaacuccc cccuccucuc cggccagcag     1980

gucuga                                                                1986


<210>  3153
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PMEL__Homo_sapiens__AAB00386

<400>  3153
auggaccugg ugcucaagag augccuucug cacuuggccg ucaucggcgc uuuacuggca       60

guuggggcca ccaaagugcc caggaaccag gauuggcuag gaguaagccg gcaacuccgc      120

acaaaggcgu ggaaucgaca gcuguacccu gaguggacug aagcucagcg ucuugacugu      180

uggagaggug gccagguguc ccugaaaguc ucuaacgaug ggccaacguu gauuggagcc      240

aaugcaucau ucaguauagc ccucaacuuu ccgggcagcc aaaaggugcu gcccgacggu      300

cagguuaucu gggugaauaa caccauuauc aauggguccc aggucugggg aggccagccu      360

guguauccac aagagacaga ugacgcuugc auuuuccccg auggcgggcc uuguccaucu      420

ggaucguggu cacagaaaag gagcuuugua uacguuugga agacuugggg ucaguauugg      480

caagugcugg gcgggcccgu caguggacuc uccaucggca ccggucgggc aauguuaggg      540

acacauacca uggaagugac uguguaccac cgcagaggau cuaggagcua ugucccucug      600

gcccauuccu caagugcuuu cacaauaacc gaccagguuc cauuuagcgu gucuguaucc      660

cagcuucggg ccuuggaugg cggcaacaag cacuuccugc gcaaucagcc gcuaacguuu      720

gcgcuccaac ugcaugaccc cucaggguac cuugcagagg ccgaucugag cuauacuugg      780

gacuucggag auaguucugg uaccuugauc ucccgagcuc ucguggucac acacacuuac      840

cuggaaccug gcccagugac cgcccagguu guguuacagg cagcuauucc ccugacaagc      900

ugcgggucgu cuccuguccc aggaaccacg gacggccaca gacccacugc cgaggcgccg      960

aacacaaccg ccggucaggu gccuacuaca gagguaguug ggaccacgcc cggccaagca     1020

ccaaccgcug aaccuuccgg aacaacuuca gugcaggucc ccaccacaga ggugaucagu     1080

acugccccag uccagaugcc caccgcugaa agcacaggca ugaccccuga gaaagugcca     1140

guuuccgagg ugauggggac uacgcucgcc gaaaugucua caccggaggc aaccggaaug     1200

acucccgccg aaguaagcau ugucgugcuu ucagguacca cagcugcgca gguuaccacu     1260

acagaguggg uggaaacgac cgcaagggag cugccuaucc cagagcccga aggcccugac     1320

gccaguucca uaaugagcac ugagucuauu acagggucau ugggaccacu acuggauggc     1380

accgcuacac uccggcuggu caagcgucaa gugccccuug acuguguacu guaccgcuau     1440

gguaguuuua gcgugacuuu ggauaucguu caggggauug aauccgccga gauccuccag     1500

gcagucccgu cuggcgaagg agacgccuuc gagcugaccg ugucgugcca gggcggguua     1560

ccuaaagagg cuuguaugga aaucagcucc ccaggaugcc aacccccugc ccagagacug     1620

ugucagcccg ugcuaccaag uccugcaugc cagcucgucc ugcaucaaau ucuuaagggu     1680

ggcucaggga cguacuguuu gaauguuucu cuggcggaua ccaacagccu cgcuguggug     1740

uccacacagc ugauaaugcc cggacaggag gccggccuug gucaaguacc acugaucguc     1800

gggauuuugc ucgugcugau ggcaguugug uuagccucac ugaucuauag gcggcgacua     1860

augaaacagg acuuuagcgu cccgcagcuc ccucacucuu ccagucauug gcugcgccuu     1920

cccagaauau ucugcagcug cccaauuggc gaaaauucuc ccuugcuguc cggacagcaa     1980

guguga                                                                1986


<210>  3154
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PMEL__Homo_sapiens__AAB00386

<400>  3154
auggaccugg ugcugaagag augccugcug caccuggccg ugaucggcgc ccugcuggcc       60

gugggcgcca ccaaggugcc cagaaaccag gacuggcugg gcgugagcag acagcugaga      120

accaaggccu ggaacagaca gcuguacccc gaguggaccg aggcccagag acuggacugc      180

uggagaggcg gccaggugag ccugaaggug agcaacgacg gccccacccu gaucggcgcc      240

aacgccagcu ucagcaucgc ccugaacuuc cccggcagcc agaaggugcu gcccgacggc      300

caggugaucu gggugaacaa caccaucauc aacggcagcc aggugugggg cggccagccc      360

guguaccccc aggagaccga cgacgccugc aucuuccccg acggcggccc cugccccagc      420

ggcagcugga gccagaagag aagcuucgug uacgugugga agaccugggg ccaguacugg      480

caggugcugg gcggccccgu gagcggccug agcaucggca ccggcagagc caugcugggc      540

acccacacca uggaggugac cguguaccac agaagaggca gcagaagcua cgugccccug      600

gcccacagca gcagcgccuu caccaucacc gaccaggugc ccuucagcgu gagcgugagc      660

cagcugagag cccuggacgg cggcaacaag cacuuccuga gaaaccagcc ccugaccuuc      720

gcccugcagc ugcacgaccc cagcggcuac cuggccgagg ccgaccugag cuacaccugg      780

gacuucggcg acagcagcgg cacccugauc agcagagccc ugguggugac ccacaccuac      840

cuggagcccg gccccgugac cgcccaggug gugcugcagg ccgccauccc ccugaccagc      900

ugcggcagca gccccgugcc cggcaccacc gacggccaca gacccaccgc cgaggccccc      960

aacaccaccg ccggccaggu gcccaccacc gagguggugg gcaccacccc cggccaggcc     1020

cccaccgccg agcccagcgg caccaccagc gugcaggugc ccaccaccga ggugaucagc     1080

accgcccccg ugcagaugcc caccgccgag agcaccggca ugacccccga gaaggugccc     1140

gugagcgagg ugaugggcac cacccuggcc gagaugagca cccccgaggc caccggcaug     1200

acccccgccg aggugagcau cguggugcug agcggcacca ccgccgccca ggugaccacc     1260

accgaguggg uggagaccac cgccagagag cugcccaucc ccgagcccga gggccccgac     1320

gccagcagca ucaugagcac cgagagcauc accggcagcc ugggcccccu gcuggacggc     1380

accgccaccc ugagacuggu gaagagacag gugccccugg acugcgugcu guacagauac     1440

ggcagcuuca gcgugacccu ggacaucgug cagggcaucg agagcgccga gauccugcag     1500

gccgugccca gcggcgaggg cgacgccuuc gagcugaccg ugagcugcca gggcggccug     1560

cccaaggagg ccugcaugga gaucagcagc cccggcugcc agccccccgc ccagagacug     1620

ugccagcccg ugcugcccag ccccgccugc cagcuggugc ugcaccagau ccugaagggc     1680

ggcagcggca ccuacugccu gaacgugagc cuggccgaca ccaacagccu ggccguggug     1740

agcacccagc ugaucaugcc cggccaggag gccggccugg gccaggugcc ccugaucgug     1800

ggcauccugc uggugcugau ggccguggug cuggccagcc ugaucuacag aagaagacug     1860

augaagcagg acuucagcgu gccccagcug ccccacagca gcagccacug gcugagacug     1920

cccagaaucu ucugcagcug ccccaucggc gagaacagcc cccugcugag cggccagcag     1980

guguga                                                                1986


<210>  3155
<211>  1986
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PMEL__Homo_sapiens__AAB00386

<400>  3155
auggaccugg ugcucaagag augccugcuu caccuggccg ucaucggcgc ucuccuggcc       60

guuggggcga ccaaagugcc ccggaaccag gauuggcuug gagugagccg ccaacugaga      120

acaaaggcuu ggaaucggca gcucuacccu gaguggacgg aagcccagcg ccuggacugu      180

uggagaggcg ggcaggucuc ccugaaagug ucuaacgaug gaccgacccu cauuggcgcc      240

aaugcuagcu ucuccaucgc ccugaacuuu cccgggucuc aaaagguucu uccugacgga      300

caggugauuu gggucaauaa cacaaucauu aauggcagcc aggugugggg cgggcagccc      360

guuuauccuc aagagaccga ugacgcuugc aucuuccccg auggaggccc uuguccgucc      420

gggucuugga gccagaaacg guccuuugug uacgucugga agacaugggg acaguauugg      480

caagugcugg gcgggcccgu gagcggacuc ucuaucggca ccggccgcgc caugcugggg      540

acacauacca uggaagucac gguuuaccac agacggggau cccgcagcua ugugccucuu      600

gcgcauucuu ccagcgccuu caccauuaca gaccaggugc ccuuuucugu cuccgugagc      660

cagcugagag cucucgaugg cgggaacaag cacuuccugc ggaaucagcc ucugaccuuu      720

gcccuccaac ugcaugaccc cuccggauac cuugcugagg ccgaucuguc uuauacaugg      780

gacuucggcg auagcuccgg gacccucauc agccgcgcgc ugguugugac gcacacauac      840

cuugaaccgg gaccugucac cgcccaggug guucugcagg cugccauucc ccucacaucu      900

ugcggcucca gcccugugcc cggcaccacc gacgggcaca gacccacagc ugaggccccu      960

aacacgaccg ccggacaggu cccgacaacc gagguggucg gcacaacccc cgggcaagcu     1020

ccuacggcgg aacccucugg aacaaccagc gugcagguuc cuaccacaga ggugaucucc     1080

accgcccccg uccagaugcc gacagcugaa ucuacgggca ugaccccuga gaaagugccc     1140

guuagcgagg ugauggggac aacccuggcc gaaaugucca caccugaggc caccggcaug     1200

acgcccgcug aagucagcau uguggugcug ucuggaacca cagccgcgca gguuaccaca     1260

accgaguggg ucgaaacgac agcucgggag cucccuaucc ccgagccgga aggcccugac     1320

gccuccagca uuaugucuac cgaguccauc acagggagcc ugggaccccu ucuggauggc     1380

accgccaccc uccgccuggu gaagagacaa gugccccuug acuguguccu guaccgguau     1440

ggguccuuuu cugugacacu cgauaucguu cagggaauug aaagcgcuga gauccugcag     1500

gccgugccuu ccggcgaagg ggacgcuuuc gagcugacgg ucucuugcca gggcggacuc     1560

ccgaaagagg ccuguaugga aauuagcucc cccggcugcc aaccucccgc gcagagacug     1620

ugucagccug ugcuucccag cccugccugc cagcugguuc uccaucaaau ccugaaaggg     1680

ggaucuggca ccuacugucu gaaugugucc cuugcugaua caaacagccu cgccgucgug     1740

ucuacccagc ugauuaugcc cgggcaggag gcuggacugg gccaaguucc gcucaucgug     1800

gggauccugc uuguccugau ggccguggug cucgcguccc ugauuuaucg ccggagacug     1860

augaagcagg acuuuagcgu cccucagcuu ccccacucua gcucccauug gcuccgccug     1920

ccucggaucu ucugcagcug ccccauuggc gaaaauucuc cgcugcucuc cggacagcaa     1980

guuuga                                                                1986


<210>  3156
<211>  882
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PML__Homo_sapiens__P29590

<400>  3156

Met Glu Pro Ala Pro Ala Arg Ser Pro Arg Pro Gln Gln Asp Pro Ala 
1               5                   10                  15      


Arg Pro Gln Glu Pro Thr Met Pro Pro Pro Glu Thr Pro Ser Glu Gly 
            20                  25                  30          


Arg Gln Pro Ser Pro Ser Pro Ser Pro Thr Glu Arg Ala Pro Ala Ser 
        35                  40                  45              


Glu Glu Glu Phe Gln Phe Leu Arg Cys Gln Gln Cys Gln Ala Glu Ala 
    50                  55                  60                  


Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr Leu Cys Ser Gly Cys 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Met Gln Cys Pro Ile Cys Gln Ala Pro Trp Pro 
                85                  90                  95      


Leu Gly Ala Asp Thr Pro Ala Leu Asp Asn Val Phe Phe Glu Ser Leu 
            100                 105                 110         


Gln Arg Arg Leu Ser Val Tyr Arg Gln Ile Val Asp Ala Gln Ala Val 
        115                 120                 125             


Cys Thr Arg Cys Lys Glu Ser Ala Asp Phe Trp Cys Phe Glu Cys Glu 
    130                 135                 140                 


Gln Leu Leu Cys Ala Lys Cys Phe Glu Ala His Gln Trp Phe Leu Lys 
145                 150                 155                 160 


His Glu Ala Arg Pro Leu Ala Glu Leu Arg Asn Gln Ser Val Arg Glu 
                165                 170                 175     


Phe Leu Asp Gly Thr Arg Lys Thr Asn Asn Ile Phe Cys Ser Asn Pro 
            180                 185                 190         


Asn His Arg Thr Pro Thr Leu Thr Ser Ile Tyr Cys Arg Gly Cys Ser 
        195                 200                 205             


Lys Pro Leu Cys Cys Ser Cys Ala Leu Leu Asp Ser Ser His Ser Glu 
    210                 215                 220                 


Leu Lys Cys Asp Ile Ser Ala Glu Ile Gln Gln Arg Gln Glu Glu Leu 
225                 230                 235                 240 


Asp Ala Met Thr Gln Ala Leu Gln Glu Gln Asp Ser Ala Phe Gly Ala 
                245                 250                 255     


Val His Ala Gln Met His Ala Ala Val Gly Gln Leu Gly Arg Ala Arg 
            260                 265                 270         


Ala Glu Thr Glu Glu Leu Ile Arg Glu Arg Val Arg Gln Val Val Ala 
        275                 280                 285             


His Val Arg Ala Gln Glu Arg Glu Leu Leu Glu Ala Val Asp Ala Arg 
    290                 295                 300                 


Tyr Gln Arg Asp Tyr Glu Glu Met Ala Ser Arg Leu Gly Arg Leu Asp 
305                 310                 315                 320 


Ala Val Leu Gln Arg Ile Arg Thr Gly Ser Ala Leu Val Gln Arg Met 
                325                 330                 335     


Lys Cys Tyr Ala Ser Asp Gln Glu Val Leu Asp Met His Gly Phe Leu 
            340                 345                 350         


Arg Gln Ala Leu Cys Arg Leu Arg Gln Glu Glu Pro Gln Ser Leu Gln 
        355                 360                 365             


Ala Ala Val Arg Thr Asp Gly Phe Asp Glu Phe Lys Val Arg Leu Gln 
    370                 375                 380                 


Asp Leu Ser Ser Cys Ile Thr Gln Gly Lys Asp Ala Ala Val Ser Lys 
385                 390                 395                 400 


Lys Ala Ser Pro Glu Ala Ala Ser Thr Pro Arg Asp Pro Ile Asp Val 
                405                 410                 415     


Asp Leu Pro Glu Glu Ala Glu Arg Val Lys Ala Gln Val Gln Ala Leu 
            420                 425                 430         


Gly Leu Ala Glu Ala Gln Pro Met Ala Val Val Gln Ser Val Pro Gly 
        435                 440                 445             


Ala His Pro Val Pro Val Tyr Ala Phe Ser Ile Lys Gly Pro Ser Tyr 
    450                 455                 460                 


Gly Glu Asp Val Ser Asn Thr Thr Thr Ala Gln Lys Arg Lys Cys Ser 
465                 470                 475                 480 


Gln Thr Gln Cys Pro Arg Lys Val Ile Lys Met Glu Ser Glu Glu Gly 
                485                 490                 495     


Lys Glu Ala Arg Leu Ala Arg Ser Ser Pro Glu Gln Pro Arg Pro Ser 
            500                 505                 510         


Thr Ser Lys Ala Val Ser Pro Pro His Leu Asp Gly Pro Pro Ser Pro 
        515                 520                 525             


Arg Ser Pro Val Ile Gly Ser Glu Val Phe Leu Pro Asn Ser Asn His 
    530                 535                 540                 


Val Ala Ser Gly Ala Gly Glu Ala Glu Glu Arg Val Val Val Ile Ser 
545                 550                 555                 560 


Ser Ser Glu Asp Ser Asp Ala Glu Asn Ser Ser Ser Arg Glu Leu Asp 
                565                 570                 575     


Asp Ser Ser Ser Glu Ser Ser Asp Leu Gln Leu Glu Gly Pro Ser Thr 
            580                 585                 590         


Leu Arg Val Leu Asp Glu Asn Leu Ala Asp Pro Gln Ala Glu Asp Arg 
        595                 600                 605             


Pro Leu Val Phe Phe Asp Leu Lys Ile Asp Asn Glu Thr Gln Lys Ile 
    610                 615                 620                 


Ser Gln Leu Ala Ala Val Asn Arg Glu Ser Lys Phe Arg Val Val Ile 
625                 630                 635                 640 


Gln Pro Glu Ala Phe Phe Ser Ile Tyr Ser Lys Ala Val Ser Leu Glu 
                645                 650                 655     


Val Gly Leu Gln His Phe Leu Ser Phe Leu Ser Ser Met Arg Arg Pro 
            660                 665                 670         


Ile Leu Ala Cys Tyr Lys Leu Trp Gly Pro Gly Leu Pro Asn Phe Phe 
        675                 680                 685             


Arg Ala Leu Glu Asp Ile Asn Arg Leu Trp Glu Phe Gln Glu Ala Ile 
    690                 695                 700                 


Ser Gly Phe Leu Ala Ala Leu Pro Leu Ile Arg Glu Arg Val Pro Gly 
705                 710                 715                 720 


Ala Ser Ser Phe Lys Leu Lys Asn Leu Ala Gln Thr Tyr Leu Ala Arg 
                725                 730                 735     


Asn Met Ser Glu Arg Ser Ala Met Ala Ala Val Leu Ala Met Arg Asp 
            740                 745                 750         


Leu Cys Arg Leu Leu Glu Val Ser Pro Gly Pro Gln Leu Ala Gln His 
        755                 760                 765             


Val Tyr Pro Phe Ser Ser Leu Gln Cys Phe Ala Ser Leu Gln Pro Leu 
    770                 775                 780                 


Val Gln Ala Ala Val Leu Pro Arg Ala Glu Ala Arg Leu Leu Ala Leu 
785                 790                 795                 800 


His Asn Val Ser Phe Met Glu Leu Leu Ser Ala His Arg Arg Asp Arg 
                805                 810                 815     


Gln Gly Gly Leu Lys Lys Tyr Ser Arg Tyr Leu Ser Leu Gln Thr Thr 
            820                 825                 830         


Thr Leu Pro Pro Ala Gln Pro Ala Phe Asn Leu Gln Ala Leu Gly Thr 
        835                 840                 845             


Tyr Phe Glu Gly Leu Leu Glu Gly Pro Ala Leu Ala Arg Ala Glu Gly 
    850                 855                 860                 


Val Ser Thr Pro Leu Ala Gly Arg Gly Leu Ala Glu Arg Ala Ser Gln 
865                 870                 875                 880 


Gln Ser 
        


<210>  3157
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PML__Homo_sapiens__CCDS10255.1

<400>  3157
auggagccug cacccgcccg aucuccgagg ccccagcagg accccgcccg gccccaggag       60

cccaccaugc cuccccccga gacccccucu gaaggccgcc agcccagccc cagccccagc      120

ccuacagagc gagcccccgc uucggaggag gaguuccagu uucugcgcug ccagcaaugc      180

caggcggaag ccaagugccc gaagcugcug ccuugucugc acacgcugug cucaggaugc      240

cuggaggcgu cgggcaugca gugccccauc ugccaggcgc ccuggccccu aggugcagac      300

acacccgccc uggauaacgu cuuuuucgag agucugcagc ggcgccuguc gguguaccgg      360

cagauugugg augcgcaggc ugugugcacc cgcugcaaag agucggccga cuucuggugc      420

uuugagugcg agcagcuccu cugcgccaag ugcuucgagg cacaccagug guuccucaag      480

cacgaggccc ggccccuagc agagcugcgc aaccagucgg ugcgugaguu ccuggacggc      540

acccgcaaga ccaacaacau cuucugcucc aaccccaacc accgcacccc uacgcugacc      600

agcaucuacu gccgaggaug uuccaagccg cugugcugcu cgugcgcgcu ccuugacagc      660

agccacagug agcucaagug cgacaucagc gcagagaucc agcagcgaca ggaggagcug      720

gacgccauga cgcaggcgcu gcaggagcag gauagugccu uuggcgcggu ucacgcgcag      780

augcacgcgg ccgucggcca gcugggccgc gcgcgugccg agaccgagga gcugauccgc      840

gagcgcgugc gccagguggu agcucacgug cgggcucagg agcgcgagcu gcuggaggcu      900

guggacgcgc gguaccagcg cgacuacgag gagauggcca gucggcuggg ccgccuggau      960

gcugugcugc agcgcauccg cacgggcagc gcgcuggugc agaggaugaa gugcuacgcc     1020

ucggaccagg aggugcugga caugcacggu uuccugcgcc aggcgcucug ccgccugcgc     1080

caggaggagc cccagagccu gcaagcugcc gugcgcaccg auggcuucga cgaguucaag     1140

gugcgccugc aggaccucag cucuugcauc acccagggga aagaugcagc uguauccaag     1200

aaagccagcc cagaggcugc cagcacuccc agggacccua uugacguuga ccugcccgag     1260

gaggcagaga gagugaaggc ccagguucag gcccuggggc uggcugaagc ccagccuaug     1320

gcugugguac agucagugcc cggggcacac cccgugccag uguacgccuu cuccaucaaa     1380

ggcccuuccu auggagagga ugucuccaau acaacgacag cccagaagag gaagugcagc     1440

cagacccagu gccccaggaa ggucaucaag auggagucug aggaggggaa ggaggcaagg     1500

uuggcucgga gcuccccgga gcagcccagg cccagcaccu ccaaggcagu cucaccaccc     1560

caccuggaug gaccgccuag ccccaggagc cccgucauag gaagugaggu cuuccugccc     1620

aacagcaacc acguggccag uggcgccggg gaggcagagg aacgcguugu ggugaucagc     1680

agcucggaag acucagaugc cgaaaacucg uccucccgag agcuggauga cagcagcagu     1740

gaguccagug accuccagcu ggaaggcccc agcacccuca ggguccugga cgagaaccuu     1800

gcugaccccc aagcagaaga cagaccucug guuuucuuug accucaagau ugacaaugaa     1860

acccagaaga uuagccagcu ggcugcggug aaccgggaaa gcaaguuccg cguggucauc     1920

cagccugaag ccuucuucag caucuacucc aaggccgugu cccuggaggu ggggcugcag     1980

cacuuccuca gcuuucugag cuccaugcgc cgcccuaucu uggccugcua caagcugugg     2040

gggccuggcc ucccaaacuu cuuccgggcc cuggaggaca uuaacaggcu gugggaauuc     2100

caggaggcca ucucgggcuu ccuggcugcc cugccucuca uccgggagcg ugugcccggg     2160

gccagcagcu ucaaacucaa gaaccuggcc cagaccuacc uggcgagaaa caugagcgag     2220

cgcagcgcca uggcugccgu gcuggccaug cgugaccugu gccgccuccu cgaggucucc     2280

ccgggccccc agcuggccca gcaugucuac cccuucagua gccugcagug cuuugccucc     2340

cugcagcccc uggugcaggc agcugugcug ccccgggcug aggcccgccu ccuggcccua     2400

cacaacguga gcuucaugga gcugcugagu gcacaccgcc gugaccggca ggggggccug     2460

aagaaguaca gccgcuaucu aagccugcag accaccacgu ugcccccugc ccagccugcu     2520

uucaaccugc aggcucuggg caccuacuuu gaaggccugu uggagggucc ggcgcuggca     2580

cgggcagaag gagucuccac cccacuugcu ggccguggcu uggcagagag ggccucccag     2640

cagagcuga                                                             2649


<210>  3158
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PML__Homo_sapiens__CCDS10255.1

<400>  3158
auggagcccg ccccggcccg cagcccccgg ccccagcagg accccgcgcg cccgcaggag       60

cccaccaugc ccccgcccga gacccccucc gagggccggc agcccagccc cuccccgagc      120

cccaccgagc gcgcccccgc cuccgaggag gaguuccagu uccugcggug ccagcagugc      180

caggccgagg ccaagugccc caagcuccug ccgugccugc acacccucug cagcgggugc      240

cuggaggcgu ccggcaugca gugccccauc ugccaggccc ccuggccccu gggggccgac      300

accccggccc ucgacaacgu guucuucgag agccugcagc gccggcuguc cgucuaccgc      360

cagaucgugg acgcgcaggc cgugugcacc cggugcaagg agagcgccga cuucuggugc      420

uucgagugcg agcagcuccu gugcgccaag ugcuucgagg cccaccagug guuccugaag      480

cacgaggcgc gcccccucgc cgagcugcgg aaccaguccg uccgcgaguu ccuggacggc      540

acgcggaaga ccaacaacau cuucugcagc aaccccaacc accgcacccc cacccucacg      600

uccaucuacu gccgggggug cagcaagccg cugugcugcu ccugcgcccu gcucgacagc      660

ucccacagcg agcugaagug cgacaucucc gccgagaucc agcagcgcca ggaggagcug      720

gacgccauga cccaggcgcu ccaggagcag gacagcgccu ucggcgccgu gcacgcccag      780

augcacgccg cggugggcca gcuggggcgg gcccgcgccg agaccgagga gcugauccgg      840

gagcgcgucc gccagguggu ggcccacguc cgggcccagg agcgcgagcu ccuggaggcg      900

guggacgccc gguaccagcg cgacuacgag gagauggcca gccggcuggg ccgccucgac      960

gccgugcugc agcggauccg caccgggucc gcgcuggucc agcggaugaa gugcuacgcc     1020

agcgaccagg aggugcucga caugcacggc uuccugcgcc aggcccugug ccggcuccgc     1080

caggaggagc cccagucccu gcaggccgcc gugcggacgg acggguucga cgaguucaag     1140

guccgccugc aggaccucag cuccugcauc acccagggca aggacgcggc cgugagcaag     1200

aaggccuccc ccgaggccgc cagcacgccc cgggacccga ucgacgugga ccugcccgag     1260

gaggcggagc gcgucaaggc ccaggugcag gcccugggcc ucgccgaggc ccagcccaug     1320

gcgguggucc aguccgugcc gggggcccac cccgugcccg ucuacgccuu cagcaucaag     1380

ggccccuccu acggggagga cgugagcaac accaccaccg cccagaagcg gaagugcucc     1440

cagacccagu gcccgcgcaa ggucaucaag auggagagcg aggagggcaa ggaggcgcgg     1500

cuggcccgcu ccagccccga gcagccccgg cccuccacca gcaaggccgu guccccgccc     1560

caccuggacg gcccgcccag cccccgcagc cccgugaucg gguccgaggu cuuccucccc     1620

aacagcaacc acguggccuc cggcgccggg gaggcggagg agcgcguggu cgugaucagc     1680

uccagcgagg acuccgacgc cgagaacagc uccagccggg agcuggacga cuccagcucc     1740

gagagcuccg accugcagcu cgagggcccc agcacgcugc gcgugcugga cgagaaccuc     1800

gccgacccgc aggccgagga ccggccccug gucuucuucg accugaagau cgacaacgag     1860

acccagaaga ucucccagcu ggccgcggug aaccgcgaga gcaaguuccg gguggucauc     1920

cagcccgagg ccuucuucag caucuacucc aaggccguga gccucgaggu ggggcugcag     1980

cacuuccugu ccuuccucag cuccaugcgc cggcccaucc uggccugcua caagcugugg     2040

ggcccgggcc uccccaacuu cuuccgcgcc cuggaggaca ucaaccggcu gugggaguuc     2100

caggaggcga ucagcggguu ccucgccgcc cugccccuga uccgcgagcg gguccccggc     2160

gccuccagcu ucaagcucaa gaaccuggcg cagaccuacc uggcccgcaa cauguccgag     2220

cggagcgcca uggccgccgu gcucgcgaug cgcgaccugu gccggcugcu cgaggugucc     2280

ccggggcccc agcuggccca gcacgucuac cccuucagcu cccugcagug cuucgccagc     2340

cuccagccgc uggugcaggc cgccgugcug ccccgcgcgg aggcccggcu ccuggcccug     2400

cacaacgucu ccuucaugga gcuccugagc gcccaccgcc gggaccgcca gggcgggcug     2460

aagaaguacu cccgguaccu cagccugcag accacgaccc ugccgcccgc ccagcccgcg     2520

uucaaccucc aggcccuggg caccuacuuc gagggccugc ucgaggggcc cgcccuggcc     2580

cgcgccgagg gcguguccac gccccuggcg gggcgcggcc ucgccgagcg ggccagccag     2640

cagagcuga                                                             2649


<210>  3159
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PML__Homo_sapiens__CCDS10255.1

<400>  3159
auggagcccg cccccgcccg cuccccccgc ccccagcagg accccgcccg cccccaggag       60

cccaccaugc ccccccccga gacccccucc gagggccgcc agcccucccc cucccccucc      120

cccaccgagc gcgcccccgc cuccgaggag gaguuccagu uccuccgcug ccagcagugc      180

caggccgagg ccaagugccc caagcuccuc cccugccucc acacccucug cuccggcugc      240

cucgaggccu ccggcaugca gugccccauc ugccaggccc ccuggccccu cggcgccgac      300

acccccgccc ucgacaacgu cuucuucgag ucccuccagc gccgccucuc cgucuaccgc      360

cagaucgucg acgcccaggc cgucugcacc cgcugcaagg aguccgccga cuucuggugc      420

uucgagugcg agcagcuccu cugcgccaag ugcuucgagg cccaccagug guuccucaag      480

cacgaggccc gcccccucgc cgagcuccgc aaccaguccg uccgcgaguu ccucgacggc      540

acccgcaaga ccaacaacau cuucugcucc aaccccaacc accgcacccc cacccucacc      600

uccaucuacu gccgcggcug cuccaagccc cucugcugcu ccugcgcccu ccucgacucc      660

ucccacuccg agcucaagug cgacaucucc gccgagaucc agcagcgcca ggaggagcuc      720

gacgccauga cccaggcccu ccaggagcag gacuccgccu ucggcgccgu ccacgcccag      780

augcacgccg ccgucggcca gcucggccgc gcccgcgccg agaccgagga gcucauccgc      840

gagcgcgucc gccaggucgu cgcccacguc cgcgcccagg agcgcgagcu ccucgaggcc      900

gucgacgccc gcuaccagcg cgacuacgag gagauggccu cccgccucgg ccgccucgac      960

gccguccucc agcgcauccg caccggcucc gcccucgucc agcgcaugaa gugcuacgcc     1020

uccgaccagg agguccucga caugcacggc uuccuccgcc aggcccucug ccgccuccgc     1080

caggaggagc cccagucccu ccaggccgcc guccgcaccg acggcuucga cgaguucaag     1140

guccgccucc aggaccucuc cuccugcauc acccagggca aggacgccgc cgucuccaag     1200

aaggccuccc ccgaggccgc cuccaccccc cgcgacccca ucgacgucga ccuccccgag     1260

gaggccgagc gcgucaaggc ccagguccag gcccucggcc ucgccgaggc ccagcccaug     1320

gccgucgucc aguccguccc cggcgcccac cccguccccg ucuacgccuu cuccaucaag     1380

ggccccuccu acggcgagga cgucuccaac accaccaccg cccagaagcg caagugcucc     1440

cagacccagu gcccccgcaa ggucaucaag auggaguccg aggagggcaa ggaggcccgc     1500

cucgcccgcu ccucccccga gcagccccgc cccuccaccu ccaaggccgu cucccccccc     1560

caccucgacg gcccccccuc cccccgcucc cccgucaucg gcuccgaggu cuuccucccc     1620

aacuccaacc acgucgccuc cggcgccggc gaggccgagg agcgcgucgu cgucaucucc     1680

uccuccgagg acuccgacgc cgagaacucc uccucccgcg agcucgacga cuccuccucc     1740

gaguccuccg accuccagcu cgagggcccc uccacccucc gcguccucga cgagaaccuc     1800

gccgaccccc aggccgagga ccgcccccuc gucuucuucg accucaagau cgacaacgag     1860

acccagaaga ucucccagcu cgccgccguc aaccgcgagu ccaaguuccg cgucgucauc     1920

cagcccgagg ccuucuucuc caucuacucc aaggccgucu cccucgaggu cggccuccag     1980

cacuuccucu ccuuccucuc cuccaugcgc cgccccaucc ucgccugcua caagcucugg     2040

ggccccggcc uccccaacuu cuuccgcgcc cucgaggaca ucaaccgccu cugggaguuc     2100

caggaggcca ucuccggcuu ccucgccgcc cucccccuca uccgcgagcg cguccccggc     2160

gccuccuccu ucaagcucaa gaaccucgcc cagaccuacc ucgcccgcaa cauguccgag     2220

cgcuccgcca uggccgccgu ccucgccaug cgcgaccucu gccgccuccu cgaggucucc     2280

cccggccccc agcucgccca gcacgucuac cccuucuccu cccuccagug cuucgccucc     2340

cuccagcccc ucguccaggc cgccguccuc ccccgcgccg aggcccgccu ccucgcccuc     2400

cacaacgucu ccuucaugga gcuccucucc gcccaccgcc gcgaccgcca gggcggccuc     2460

aagaaguacu cccgcuaccu cucccuccag accaccaccc ucccccccgc ccagcccgcc     2520

uucaaccucc aggcccucgg caccuacuuc gagggccucc ucgagggccc cgcccucgcc     2580

cgcgccgagg gcgucuccac cccccucgcc ggccgcggcc ucgccgagcg cgccucccag     2640

caguccuga                                                             2649


<210>  3160
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PML__Homo_sapiens__CCDS10255.1

<400>  3160
auggagcccg ccccugcuag aagcccaagg ccgcagcaag accccgcacg gccucaggaa       60

ccaaccaugc ccccuccaga gacacccucc gaaggccgcc agccuucucc aucaccgagu      120

cccacugagc gagccccugc gagcgaagag gaguuccagu uucugcguug ccaacagugu      180

caggcugaag ccaagugccc aaaacuccuu cccugucugc acacguugug cuccgggugu      240

uuagaggcau cuggaaugca gugcccuauc ugucaagccc cauggccccu gggugcugau      300

accccggcac uagacaacgu guucuuugaa ucgcuccaga gaaggcuguc agucuaccgg      360

cagauuguug augcccaggc ugugugcaca cgcuguaagg agagcgccga cuucuggugc      420

uuugagugug aacaacuucu gugcgcgaaa ugcuucgagg cacaucagug guuuuugaag      480

cacgaagcca gaccucucgc ugagcugagg aaucagagug uacgggaauu ucuggauggc      540

acucgcaaaa ccaacaauau auuuuguucc aaccccaauc aucgaacacc aacccucacu      600

ucuaucuauu gcagagggug uagcaagccu uuaugcuguu ccugcgcccu gcuugacuca      660

agucacagcg aguugaagug ugauauuucu gcagagaucc aacagaggca ggaagaacug      720

gacgcuauga cacaggcccu acaagaacag gauuccgcgu ucggagccgu gcaugcacag      780

augcacgcug ccgucggcca gcucggucgg gcucgugccg agaccgagga gcugauucgc      840

gagagaguga ggcaaguugu ggcacacguc cgggcccagg aacgagagcu ucuggaagcu      900

guggacgcgc gcuaccagag agauuaugag gaaauggcau caagguuggg gcggcucgac      960

gccguacugc agcgcaucag aacgggaagc gcuuuaguuc aaaggaugaa augcuacgcc     1020

agugaucagg aggugcugga caugcauggc uuucuccguc aggcacuuug ucggcugcga     1080

caggaggaac cccaaucuuu gcaggccgcu gucagaacug acggcuucga ugaguuuaag     1140

gugaggcuac aggaccuguc cagcugcaua acccaaggga aagaugccgc agugucgaag     1200

aaagcgucuc cagaagcugc cuccacaccc cgcgacccua ucgaugucga ccucccagag     1260

gaggcagaac ggguuaaggc ccaggugcag gcucugggac uugccgaggc acagccgaug     1320

gcuguagugc aaucaguccc cggugcccac ccugugccag uuuaugcguu caguauuaag     1380

ggccccagcu acggggaaga uguguccaac acuaccacag cccagaaaag aaaguguucu     1440

cagacccagu gcccuaggaa agucaucaag auggagagcg aagagggaaa agaggcucgc     1500

cuggcacgau caaguccaga acaaccccgg ccguccacga gcaaggccgu gucuccucca     1560

cauuuggacg gucccccuuc accccguagu ccaguaauug gcagcgaggu uuuccucccu     1620

aauuccaacc acguggcuuc uggggccgga gaagcagagg aaagagucgu ggucaucucg     1680

agcuccgagg auucagacgc ggagaauagu ucuagcaggg aacuggauga cuccucaagc     1740

gagucuuccg acuuacagcu ggaaggcccc aguacucuac gcgugcucga ugagaaccug     1800

gccgacccac aggcugaaga ucggccgcuu guuuucuucg acuugaaaau agauaaugag     1860

acacagaaga uuagccaacu ggccgcagug aacagagagu cuaaguuuag gguagucauc     1920

cagccugagg cuuucuuuuc cauuuauuca aaagccguga gucucgaagu uggccugcag     1980

cacuuccuua gcuuucuguc guccaugcga cgccccaucu uggcaugcua caagcucugg     2040

gggccaggac ugcccaauuu cuuucgggcc uuagaagaca ucaacagacu gugggaguuc     2100

caagaggcua uuucugguuu ucuagcggcc cucccucuga uaagggaacg ugugccaggc     2160

gcaagcucau ucaaacuuaa gaauuuggcu cagaccuacc uggcccgcaa caugagugag     2220

cgguccgcca uggcugcagu ccucgccaug agagaucugu guagguuacu ggaagugucu     2280

cccgggccuc agcuugcgca gcauguauau ccguuuagcu ccuugcaaug cuucgcuuca     2340

cuccagccac uggugcaggc cgcaguucua ccccgagccg aggcucggcu gcucgcacug     2400

cacaacguca gcuucaugga acuuuugagu gcccaucgca gagacaggca gggaggccug     2460

aaaaaguacu cucgguauuu aucccuccaa acuacaaccc ugccuccagc gcagcccgcu     2520

uuuaaucuuc aggcccuggg uacguacuuc gagggguugc ucgagggccc ugcacuggcc     2580

cgagcugaag gagugagcac cccgcuagcc ggcagagggc uggcagagcg cgcuucgcag     2640

caaucauga                                                             2649


<210>  3161
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PML__Homo_sapiens__CCDS10255.1

<400>  3161
auggagcccg cccccgccag aagccccaga ccccagcagg accccgccag accccaggag       60

cccaccaugc ccccccccga gacccccagc gagggcagac agcccagccc cagccccagc      120

cccaccgaga gagcccccgc cagcgaggag gaguuccagu uccugagaug ccagcagugc      180

caggccgagg ccaagugccc caagcugcug cccugccugc acacccugug cagcggcugc      240

cuggaggcca gcggcaugca gugccccauc ugccaggccc ccuggccccu gggcgccgac      300

acccccgccc uggacaacgu guucuucgag agccugcaga gaagacugag cguguacaga      360

cagaucgugg acgcccaggc cgugugcacc agaugcaagg agagcgccga cuucuggugc      420

uucgagugcg agcagcugcu gugcgccaag ugcuucgagg cccaccagug guuccugaag      480

cacgaggcca gaccccuggc cgagcugaga aaccagagcg ugagagaguu ccuggacggc      540

accagaaaga ccaacaacau cuucugcagc aaccccaacc acagaacccc cacccugacc      600

agcaucuacu gcagaggcug cagcaagccc cugugcugca gcugcgcccu gcuggacagc      660

agccacagcg agcugaagug cgacaucagc gccgagaucc agcagagaca ggaggagcug      720

gacgccauga cccaggcccu gcaggagcag gacagcgccu ucggcgccgu gcacgcccag      780

augcacgccg ccgugggcca gcugggcaga gccagagccg agaccgagga gcugaucaga      840

gagagaguga gacagguggu ggcccacgug agagcccagg agagagagcu gcuggaggcc      900

guggacgcca gauaccagag agacuacgag gagauggcca gcagacuggg cagacuggac      960

gccgugcugc agagaaucag aaccggcagc gcccuggugc agagaaugaa gugcuacgcc     1020

agcgaccagg aggugcugga caugcacggc uuccugagac aggcccugug cagacugaga     1080

caggaggagc cccagagccu gcaggccgcc gugagaaccg acggcuucga cgaguucaag     1140

gugagacugc aggaccugag cagcugcauc acccagggca aggacgccgc cgugagcaag     1200

aaggccagcc ccgaggccgc cagcaccccc agagacccca ucgacgugga ccugcccgag     1260

gaggccgaga gagugaaggc ccaggugcag gcccugggcc uggccgaggc ccagcccaug     1320

gccguggugc agagcgugcc cggcgcccac cccgugcccg uguacgccuu cagcaucaag     1380

ggccccagcu acggcgagga cgugagcaac accaccaccg cccagaagag aaagugcagc     1440

cagacccagu gccccagaaa ggugaucaag auggagagcg aggagggcaa ggaggccaga     1500

cuggccagaa gcagccccga gcagcccaga cccagcacca gcaaggccgu gagccccccc     1560

caccuggacg gcccccccag ccccagaagc cccgugaucg gcagcgaggu guuccugccc     1620

aacagcaacc acguggccag cggcgccggc gaggccgagg agagaguggu ggugaucagc     1680

agcagcgagg acagcgacgc cgagaacagc agcagcagag agcuggacga cagcagcagc     1740

gagagcagcg accugcagcu ggagggcccc agcacccuga gagugcugga cgagaaccug     1800

gccgaccccc aggccgagga cagaccccug guguucuucg accugaagau cgacaacgag     1860

acccagaaga ucagccagcu ggccgccgug aacagagaga gcaaguucag aguggugauc     1920

cagcccgagg ccuucuucag caucuacagc aaggccguga gccuggaggu gggccugcag     1980

cacuuccuga gcuuccugag cagcaugaga agacccaucc uggccugcua caagcugugg     2040

ggccccggcc ugcccaacuu cuucagagcc cuggaggaca ucaacagacu gugggaguuc     2100

caggaggcca ucagcggcuu ccuggccgcc cugccccuga ucagagagag agugcccggc     2160

gccagcagcu ucaagcugaa gaaccuggcc cagaccuacc uggccagaaa caugagcgag     2220

agaagcgcca uggccgccgu gcuggccaug agagaccugu gcagacugcu ggaggugagc     2280

cccggccccc agcuggccca gcacguguac cccuucagca gccugcagug cuucgccagc     2340

cugcagcccc uggugcaggc cgccgugcug cccagagccg aggccagacu gcuggcccug     2400

cacaacguga gcuucaugga gcugcugagc gcccacagaa gagacagaca gggcggccug     2460

aagaaguaca gcagauaccu gagccugcag accaccaccc ugccccccgc ccagcccgcc     2520

uucaaccugc aggcccuggg caccuacuuc gagggccugc uggagggccc cgcccuggcc     2580

agagccgagg gcgugagcac cccccuggcc ggcagaggcc uggccgagag agccagccag     2640

cagagcuga                                                             2649


<210>  3162
<211>  2649
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PML__Homo_sapiens__CCDS10255.1

<400>  3162
auggagcccg ccccugcuag aagcccgcgg ccccagcaag acccugcccg cccccaggaa       60

ccuaccaugc ccccuccgga gacacccucc gaaggcagac agccuucucc cagcccuucc      120

cccacggagc gggcgccggc uucugaagag gaguuccagu uucugcgcug ccaacagugu      180

caggccgaag ccaagugccc uaaacuccug cccugucuuc acacccugug cagcgggugu      240

cucgaggcuu ccggaaugca gugcccuauc ugucaagccc ccuggccccu gggcgcugau      300

accccugccc uugacaacgu guucuuugaa ucucugcaga gacggcucag cgucuaccgc      360

cagauuguug augcgcaggc cgugugcaca agauguaagg aguccgcuga cuucuggugc      420

uuugagugug aacaacugcu gugcgccaaa ugcuucgagg cucaucagug guuucucaag      480

cacgaagccc ggccgcuggc ggagcuucgc aaucagagcg ugagagaauu ucuggauggg      540

acacggaaaa ccaacaauau cuuuuguucu aaccccaauc aucgcacacc uacccucacg      600

uccauuuauu gcagaggaug uagcaagccc cugugcuguu cuugcgcccu ucuggacucc      660

agccacucug agcucaagug ugauaucucc gcugagauuc aacagcggca ggaggagcug      720

gacgccauga cccaggcucu gcaagaacag gauagcgccu ucggcgccgu ccaugcucag      780

augcacgcgg ccguggggca gcucggacgc gcuagagccg agacagagga acugauccgg      840

gagagaguuc gccaaguggu cgcccacgug cgggcucagg aaagagagcu ucuggaagcc      900

guugacgcgc gcuaccagcg ggauuaugag gaaauggcuu ccagacucgg ccgccuggac      960

gccgugcuuc agcggaucag aaccggcucu gcccuggucc aacgcaugaa augcuacgcu     1020

agcgaucagg aggugcucga caugcauggg uuucugcggc aggcccugug uagacuccgc     1080

caggaggaac cucaaucccu gcaggcugcc gugcggacag acggauucga ugaguuuaag     1140

gucagacuuc aggaccugag cucuugcauu acccaaggca aagaugcggc cguuuccaag     1200

aaagcuagcc ccgaagccgc uucuacgccg cgggacccua ucgaugugga ccuccccgag     1260

gaggccgaac gcgugaaggc gcagguccag gcccuggggc uugcugaggc ccagccuaug     1320

gcugugguuc aaagcgugcc cggagcccac ccuguccccg uguaugccuu cuccauuaag     1380

ggcccgucuu acggggaaga uguuagcaac acaaccacag cucagaaaag aaaguguucc     1440

cagacccagu gcccucggaa agugaucaag auggagagcg aagagggaaa agaggcgaga     1500

cuggcccggu cuucccccga acaaccccgc ccuagcaccu cuaaggcugu cuccccgccc     1560

caucucgacg gcccucccag cccuagaucc cccgugauug gcucugaggu cuuccugccu     1620

aauagcaacc acguggccuc cggggccgga gaagcugagg aacgcguugu ggucaucucu     1680

agcuccgagg auagcgacgc cgaaaauucu uccagcagag aacuggauga cucuuccagc     1740

gagucuagcg accuccagcu ggaaggcccc uccacacuuc gggugcugga ugagaaccuc     1800

gcggacccgc aggcugaaga ucgcccucug guuuucuucg accugaaaau ugauaaugag     1860

acgcagaaga ucagccaacu ugccgccgug aacagagagu cuaaguuucg ggucgugauc     1920

cagcccgagg cuuucuuuuc cauuuauagc aaagccgugu cccucgaagu ugggcugcag     1980

cacuuccugu cuuuucucag cuccaugcgc agaccuaucc uggcgugcua caaacuuugg     2040

ggacccggcc ugccgaauuu cuuucgggcu cucgaagaca uuaaccgccu gugggaguuc     2100

caagaggcca ucucuggguu ucuggccgcc cuuccucuca uuagagaacg gguccccgga     2160

gcuagcuccu ucaagcugaa gaaucuggcu cagaccuacc ucgcccgcaa caugucugag     2220

agaagcgcga uggccgcugu gcuggccaug cgggaucuuu guagacugcu cgaagugucc     2280

ccuggccccc agcuggcuca gcaugucuau cccuuuagcu cucugcaaug cuucgccucc     2340

cuucagccuc ucgugcaggc cgcuguucug ccgcgcgcgg aggcccggcu gcucgcucug     2400

cacaacguga gcuucaugga acuucugucu gcccauagac gcgaccggca gggcgggcuc     2460

aaaaaguacu ccagauaucu gagccugcaa acaaccacac uucccccugc ccagcccgcu     2520

uuuaaucucc aggcccuggg aaccuacuuc gagggccugc ucgaggggcc ugcgcuggcu     2580

cgcgccgaag gagucucuac gccccuugcc ggccgggggc uggcugagag agccucccag     2640

caaagcuga                                                             2649


<210>  3163
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  POTEF__Homo_sapiens__A5A3E0

<400>  3163

Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Pro Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Arg Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Ile Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Arg Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Val Leu Leu Thr Glu Ala Thr Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu His 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Val Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly 
        995                 1000                1005            


Met Ala His Arg Met Gln Lys Glu Ile Ala Ala Leu Ala Pro Ser Met 
    1010                1015                1020                


Met Lys Ile Arg Ile Ile Ala Pro Pro Lys Arg Lys Tyr Ser Val Trp 
1025                1030                1035                1040


Val Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe Gln Gln Met Trp 
                1045                1050                1055    


Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg 
            1060                1065                1070        


Lys Cys Leu 
        1075


<210>  3164
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  POTEF__Homo_sapiens__CCDS46409.1

<400>  3164
auggugguug agguugauuc caugccggcu gccucuucug ugaagaagcc auuuggucuc       60

aggagcaaga ugggcaagug gugcugccgu ugcuuccccu gcugcaggga gagcggcaag      120

agcaacgugg gcacuucugg agaccacgac gacucugcua ugaagacacu caggagcaag      180

augggcaagu ggugccgcca cugcuucccc ugcugcaggg ggaguggcaa gagcaacgug      240

ggcgcuucug gagaccacga cgacucugcu augaagacac ucaggaacaa gaugggcaag      300

uggugcugcc acugcuuccc cugcugcagg gggagcagca agagcaaggu gggcgcuugg      360

ggagacuacg augacagugc cuucauggag cccagguacc acguccgugg agaagaucug      420

gacaagcucc acagagcugc cugguggggu aaagucccca gaaaggaucu caucgucaug      480

cucagggaca cugacgugaa caagcaggac aagcaaaaga ggacugcucu acaucuggcc      540

ucugccaaug ggaauucaga aguaguaaaa cuccugcugg acagacgaug ucaacuuaau      600

guccuugaca acaaaaagag gacagcucug auaaaggccg uacaaugcca ggaagaugaa      660

ugugcguuaa uguugcugga acauggcacu gauccaaaua uuccagauga guauggaaau      720

accacucugc acuacgcuau cuauaaugaa gauaaauuaa uggccaaagc acugcucuua      780

uauggugcug auaucgaauc aaaaaacaag cauggccuca caccacuguu acuuggugua      840

caugagcaaa aacagcaagu cgugaaauuu uuaauuaaga aaaaagcgaa uuuaaaugca      900

cuggauagau auggaagaac ugcucucaua cuugcuguau guuguggauc agcaaguaua      960

gucagccuuc uacuugagca aaauauugau guaucuucuc aagaucuauc uggacagacg     1020

gccagagagu augcuguuuc uagucaucau cauguaauuu gccaguuacu uucugacuac     1080

aaagaaaaac agaugcuaaa aaucucuucu gaaaacagca auccagaaca agacuuaaag     1140

cugacaucag aggaagaguc acaaagguuc aaaggcagug aaaauagcca gccagagaaa     1200

augucucaag aaccagaaau aaauaaggau ggugauagag agguugaaga agaaaugaag     1260

aagcaugaaa guaauaaugu gggauuacua gaaaaccuga cuaauggugu cacugcuggc     1320

aauggugaua auggauuaau uccucaaagg aagagcagaa caccugaaaa ucagcaauuu     1380

ccugacaacg aaagugaaga guaucacaga auuugugaau uacuuucuga cuacaaagaa     1440

aagcagaugc caaaauacuc uucugaaaac agcaacccag aacaagacuu aaagcugaca     1500

ucagaggaag agucacaaag gcuuaaaggc agugaaaaug gccagccaga gaaaagaucu     1560

caagaaccag aaauaaauaa ggauggugau agagagcuag aaaauuuuau ggcuaucgaa     1620

gaaaugaaga agcacagaag uacucauguc ggauucccag aaaaccugac uaauggugcc     1680

acugcuggca auggugauga uggauuaauu ccuccaagga agagcagaac accugaaagc     1740

cagcaauuuc cugacacuga gaaugaagag uaucacagug acgaacaaaa ugauacucag     1800

aagcaauuuu gugaagaaca gaacacugga auauuacacg augagauucu gauucaugaa     1860

gaaaagcaga uagaaguggu ugaaaaaaug aauucugagc uuucucuuag uuguaagaaa     1920

gaaaaagaca ucuugcauga aaauaguacg uugcgggaag aaauugccau gcuaagacug     1980

gagcuagaca caaugaaaca ucagagccag cuaagagaaa agaaauauuu ggaggauauu     2040

gaaaguguga aaaaaaggaa ugauaaucuu uuaaaggcuc uacaauugaa ugagcucacc     2100

auggaugaug auaccgcugu gcucgucauu gacaacggcu cuggcaugug caaggccggc     2160

uuugcgggcg acgaugcccc ccgggcuguc uucccuucca ucguggggcg ccccaggcag     2220

cagggcauga uggggggcau gcaucagaaa gaguccuaug ugggcaagga ggcccagagc     2280

aaaagaggca uccugacccu gaaguacccc auggaacacg gcaucaucac caacugggau     2340

gacauggaga agaucuggca ccacaccuuc uacaacgagc ugcguguggc ucccgaggag     2400

caccccgucc ugcugaccga ggccacccug aacccuaagg ccaaccgcga gaagaugacc     2460

cagaucaugu uugagaccuu caacacccca gccauguacg uggccaucca ggcugugcug     2520

ucccuguaca ccucuggccg uacuacuggc aucgugaugg acucugguga cggggucacc     2580

cacacugugc ccaucuauga ggggaaugcc cucccccaug ccacccugcg ccuagaccug     2640

gcugggcggg aacugccuga cuaccucaug aagauccuca ccgagcaugg cuauagguuc     2700

accaccaugg ccgagcggga aaucgugcgu gacaucaaag agaagcugug cuauguugcc     2760

cuggacuucg agcaggagau ggccacggug gccuccagcu ccucccuaga gaagagcuac     2820

gagcugcccg auggccaggu caucaccauc ggcaacgagc gguuccgcug ccccgaggcg     2880

cucuuccagc cuugcuuccu gggcauggaa uccuguggca uccaugaaac uaccuucaac     2940

uccaucauga agucugaugu ggacauccgc aaagaccugu acaccaacac agugcugucu     3000

ggcggcacca ccauguaccc uggcauggcc cacagaaugc agaaggagau cgcugcccug     3060

gcgccuagca ugaugaagau caggaucauu gcuccuccca agcgcaagua cuccgugugg     3120

gucgguggcu ccauccuggc cucgcugucc accuuccagc agauguggau cagcaagcag     3180

gaguaugaug agucaggccc cuccauuguc caccgcaaau gcuuguag                  3228


<210>  3165
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       POTEF__Homo_sapiens__CCDS46409.1

<400>  3165
augguggucg agguggacag caugcccgcc gccuccagcg ugaagaagcc cuucggccug       60

cgcuccaaga uggggaagug gugcugccgg ugcuuccccu gcugccgcga gagcggcaag      120

uccaacgucg ggaccagcgg cgaccacgac gacuccgcga ugaagacccu ccggagcaag      180

auggggaagu ggugccgcca cugcuucccc ugcugccggg gcuccggcaa gagcaacgug      240

ggggccuccg gcgaccacga cgacagcgcc augaagacgc ugcgcaacaa gauggggaag      300

uggugcugcc acugcuuccc cugcugccgg ggcuccagca aguccaaggu gggggccugg      360

ggcgacuacg acgacagcgc cuucauggag ccgcgcuacc acguccgggg cgaggaccug      420

gacaagcucc accgcgcggc cugguggggg aaggugcccc ggaaggaccu gaucgugaug      480

cugcgcgaca ccgacgucaa caagcaggac aagcagaagc ggaccgcccu ccaccuggcc      540

uccgcgaacg gcaacagcga gguggugaag cugcuccugg accgccggug ccagcugaac      600

guccucgaca acaagaagcg caccgcccug aucaaggccg ugcagugcca ggaggacgag      660

ugcgcccuga ugcuccugga gcacgggacg gaccccaaca uccccgacga guacggcaac      720

accacccugc acuacgccau cuacaacgag gacaagcuca uggcgaaggc ccugcugcuc      780

uacggcgccg acaucgaguc caagaacaag cacgggcuga ccccgcugcu ccugggcgug      840

cacgagcaga agcagcaggu cgugaaguuc cugaucaaga agaaggccaa ccucaacgcc      900

cuggaccggu acgggcgcac ggcgcugauc cucgccgugu gcugcggcag cgccagcauc      960

gucucccugc ugcucgagca gaacaucgac gugagcuccc aggaccugag cgggcagacc     1020

gcccgggagu acgccguguc cagccaccac cacgucaucu gccagcugcu cuccgacuac     1080

aaggagaagc agaugcugaa gaucagcucc gagaacagca accccgagca ggaccugaag     1140

cucaccuccg aggaggagag ccagcgcuuc aagggcuccg agaacagcca gcccgagaag     1200

augucccagg agcccgagau caacaaggac ggcgaccggg agguggagga ggagaugaag     1260

aagcacgaga gcaacaacgu ggggcugcug gagaaccuca ccaacggcgu cacggcgggg     1320

aacggcgaca acgggcugau cccgcagcgc aagucccgca cccccgagaa ccagcaguuc     1380

cccgacaacg agagcgagga guaccaccgg aucugcgagc ugcucuccga cuacaaggag     1440

aagcagaugc ccaaguacag cagcgagaac uccaacccgg agcaggaccu gaagcugacc     1500

agcgaggagg agucccagcg ccucaagggc agcgagaacg gccagcccga gaagcggucc     1560

caggagcccg agaucaacaa ggacggggac cgcgagcugg agaacuucau ggccaucgag     1620

gagaugaaga agcaccggag cacccacgug ggcuuccccg agaaccugac gaacggggcc     1680

accgccggca acggggacga cggccugauc ccgccccgca agucccggac ccccgagagc     1740

cagcaguucc ccgacaccga gaacgaggag uaccacuccg acgagcagaa cgacacgcag     1800

aagcaguucu gcgaggagca gaacaccggc auccuccacg acgagauccu gauccacgag     1860

gagaagcaga ucgaggucgu ggagaagaug aacagcgagc ugucccucag cugcaagaag     1920

gagaaggaca uccugcacga gaacuccacc cugcgcgagg agaucgccau gcuccggcug     1980

gagcuggaca ccaugaagca ccagagccag cuccgcgaga agaaguaccu ggaggacauc     2040

gaguccguga agaagcggaa cgacaaccug cucaaggcgc ugcagcugaa cgagcucacg     2100

auggacgacg acaccgccgu ccuggugauc gacaacggga gcggcaugug caaggccggg     2160

uucgccggcg acgacgcgcc gcgcgccgug uuccccucca ucgucggccg gccccgccag     2220

caggggauga ugggcgggau gcaccagaag gagagcuacg ugggcaagga ggcccagagc     2280

aagcggggga uccugacccu caaguacccc auggagcacg gcaucaucac caacugggac     2340

gacauggaga agaucuggca ccacacguuc uacaacgagc ugcgcguggc cccggaggag     2400

caccccgucc ugcucaccga ggccacccug aaccccaagg cgaaccggga gaagaugacc     2460

cagaucaugu ucgagacguu caacaccccg gccauguacg uggccaucca ggccgugcug     2520

ucccucuaca ccagcggccg caccacgggg aucgucaugg acuccggcga cggggugacc     2580

cacaccgugc ccaucuacga gggcaacgcc cugccccacg cgacccugcg gcucgaccug     2640

gccgggcgcg agcugcccga cuaccucaug aagauccuga ccgagcacgg cuaccgcuuc     2700

acgaccaugg ccgagcggga gaucguccgc gacaucaagg agaagcugug cuacguggcc     2760

cucgacuucg agcaggagau ggccaccgug gcgagcucca gcucccugga gaaguccuac     2820

gagcugccgg acggccaggu caucaccauc gggaacgagc gguuccgcug ccccgaggcc     2880

cucuuccagc ccugcuuccu gggcauggag agcugcggga uccacgagac gaccuucaac     2940

agcaucauga aguccgacgu ggacauccgg aaggaccugu acaccaacac cgugcucagc     3000

ggcgggacga ccauguaccc cggcauggcc caccgcaugc agaaggagau cgccgcgcug     3060

gccccgucca ugaugaagau ccggaucauc gccccgccca agcgcaagua cagcgucugg     3120

gugggcgggu ccauccuggc cagccucucc accuuccagc agauguggau cagcaagcag     3180

gaguacgacg aguccggccc cagcaucgug caccggaagu gccuguga                  3228


<210>  3166
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       POTEF__Homo_sapiens__CCDS46409.1

<400>  3166
auggucgucg aggucgacuc caugcccgcc gccuccuccg ucaagaagcc cuucggccuc       60

cgcuccaaga ugggcaagug gugcugccgc ugcuuccccu gcugccgcga guccggcaag      120

uccaacgucg gcaccuccgg cgaccacgac gacuccgcca ugaagacccu ccgcuccaag      180

augggcaagu ggugccgcca cugcuucccc ugcugccgcg gcuccggcaa guccaacguc      240

ggcgccuccg gcgaccacga cgacuccgcc augaagaccc uccgcaacaa gaugggcaag      300

uggugcugcc acugcuuccc cugcugccgc ggcuccucca aguccaaggu cggcgccugg      360

ggcgacuacg acgacuccgc cuucauggag ccccgcuacc acguccgcgg cgaggaccuc      420

gacaagcucc accgcgccgc cugguggggc aagguccccc gcaaggaccu caucgucaug      480

cuccgcgaca ccgacgucaa caagcaggac aagcagaagc gcaccgcccu ccaccucgcc      540

uccgccaacg gcaacuccga ggucgucaag cuccuccucg accgccgcug ccagcucaac      600

guccucgaca acaagaagcg caccgcccuc aucaaggccg uccagugcca ggaggacgag      660

ugcgcccuca ugcuccucga gcacggcacc gaccccaaca uccccgacga guacggcaac      720

accacccucc acuacgccau cuacaacgag gacaagcuca uggccaaggc ccuccuccuc      780

uacggcgccg acaucgaguc caagaacaag cacggccuca ccccccuccu ccucggcguc      840

cacgagcaga agcagcaggu cgucaaguuc cucaucaaga agaaggccaa ccucaacgcc      900

cucgaccgcu acggccgcac cgcccucauc cucgccgucu gcugcggcuc cgccuccauc      960

gucucccucc uccucgagca gaacaucgac gucuccuccc aggaccucuc cggccagacc     1020

gcccgcgagu acgccgucuc cucccaccac cacgucaucu gccagcuccu cuccgacuac     1080

aaggagaagc agaugcucaa gaucuccucc gagaacucca accccgagca ggaccucaag     1140

cucaccuccg aggaggaguc ccagcgcuuc aagggcuccg agaacuccca gcccgagaag     1200

augucccagg agcccgagau caacaaggac ggcgaccgcg aggucgagga ggagaugaag     1260

aagcacgagu ccaacaacgu cggccuccuc gagaaccuca ccaacggcgu caccgccggc     1320

aacggcgaca acggccucau cccccagcgc aagucccgca cccccgagaa ccagcaguuc     1380

cccgacaacg aguccgagga guaccaccgc aucugcgagc uccucuccga cuacaaggag     1440

aagcagaugc ccaaguacuc cuccgagaac uccaaccccg agcaggaccu caagcucacc     1500

uccgaggagg agucccagcg ccucaagggc uccgagaacg gccagcccga gaagcgcucc     1560

caggagcccg agaucaacaa ggacggcgac cgcgagcucg agaacuucau ggccaucgag     1620

gagaugaaga agcaccgcuc cacccacguc ggcuuccccg agaaccucac caacggcgcc     1680

accgccggca acggcgacga cggccucauc cccccccgca agucccgcac ccccgagucc     1740

cagcaguucc ccgacaccga gaacgaggag uaccacuccg acgagcagaa cgacacccag     1800

aagcaguucu gcgaggagca gaacaccggc auccuccacg acgagauccu cauccacgag     1860

gagaagcaga ucgaggucgu cgagaagaug aacuccgagc ucucccucuc cugcaagaag     1920

gagaaggaca uccuccacga gaacuccacc cuccgcgagg agaucgccau gcuccgccuc     1980

gagcucgaca ccaugaagca ccagucccag cuccgcgaga agaaguaccu cgaggacauc     2040

gaguccguca agaagcgcaa cgacaaccuc cucaaggccc uccagcucaa cgagcucacc     2100

auggacgacg acaccgccgu ccucgucauc gacaacggcu ccggcaugug caaggccggc     2160

uucgccggcg acgacgcccc ccgcgccguc uuccccucca ucgucggccg cccccgccag     2220

cagggcauga ugggcggcau gcaccagaag gaguccuacg ucggcaagga ggcccagucc     2280

aagcgcggca uccucacccu caaguacccc auggagcacg gcaucaucac caacugggac     2340

gacauggaga agaucuggca ccacaccuuc uacaacgagc uccgcgucgc ccccgaggag     2400

caccccgucc uccucaccga ggccacccuc aaccccaagg ccaaccgcga gaagaugacc     2460

cagaucaugu ucgagaccuu caacaccccc gccauguacg ucgccaucca ggccguccuc     2520

ucccucuaca ccuccggccg caccaccggc aucgucaugg acuccggcga cggcgucacc     2580

cacaccgucc ccaucuacga gggcaacgcc cucccccacg ccacccuccg ccucgaccuc     2640

gccggccgcg agcuccccga cuaccucaug aagauccuca ccgagcacgg cuaccgcuuc     2700

accaccaugg ccgagcgcga gaucguccgc gacaucaagg agaagcucug cuacgucgcc     2760

cucgacuucg agcaggagau ggccaccguc gccuccuccu ccucccucga gaaguccuac     2820

gagcuccccg acggccaggu caucaccauc ggcaacgagc gcuuccgcug ccccgaggcc     2880

cucuuccagc ccugcuuccu cggcauggag uccugcggca uccacgagac caccuucaac     2940

uccaucauga aguccgacgu cgacauccgc aaggaccucu acaccaacac cguccucucc     3000

ggcggcacca ccauguaccc cggcauggcc caccgcaugc agaaggagau cgccgcccuc     3060

gcccccucca ugaugaagau ccgcaucauc gcccccccca agcgcaagua cuccgucugg     3120

gucggcggcu ccauccucgc cucccucucc accuuccagc agauguggau cuccaagcag     3180

gaguacgacg aguccggccc cuccaucguc caccgcaagu gccucuga                  3228


<210>  3167
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       POTEF__Homo_sapiens__CCDS46409.1

<400>  3167
augguggucg agguugacag caugcccgcc gcuuccucug ugaagaaacc uuucggccug       60

agaucaaaga uggggaaaug gugcuguagg ugcuuuccau guugccggga aaguggaaag      120

agcaacguag guaccuccgg cgaucacgac gauucugcaa ugaaaacacu ccgcucgaag      180

auggggaagu ggugucgaca uugcuucccg uguugccgug gaucaggcaa aagcaaugug      240

ggugccagug gggaccacga ugacuccgcg augaagacuc uuagaaacaa aaugggaaag      300

ugguguugcc auuguuuucc cugcugcagg ggcucuagca aauccaaggu cggcgcuugg      360

ggagauuacg acgauucagc cuucauggag ccucgguauc acgugcgcgg ggaagaccug      420

gauaaguugc auagagcagc cugguggggu aaaguuccaa ggaaggacuu aaucgugaug      480

cugcgggaua cggacgucaa uaaacaggac aagcaaaaac gcaccgcucu acaccucgca      540

agugccaacg gcaauagcga ggugguaaag cugcuucugg aucgaagaug ucaguugaac      600

guucucgaca auaaaaagag gacagcucug auuaaggccg ugcagugcca ggaagaugag      660

ugugcgcuga ugcucuuaga gcacgggacu gaccccaaca uaccugauga auacggaaau      720

accacacugc auuaugcaau cuacaacgag gacaaacuua uggccaaggc uuugcugcua      780

uauggcgccg auauugaauc uaaaaauaag cacggucuca ccccacugcu ucuggggguc      840

caugagcaaa aacaacaggu ggugaaguuu uugaucaaga aaaaggcaaa ccucaaugcu      900

cuggaccggu acggacguac ugccuuaauu cuggcggucu gcuguggcuc cgccucaauc      960

guuagccucc uucuggagca gaacauagau gugaguucuc aggacuuguc cggccagaca     1020

gcacgcgaau augcuguaag cucgcaccac caugugaucu gccagcuacu gucugauuac     1080

aaagagaagc agaugcucaa aauuuccuca gaaaauagua accccgagca agaccugaaa     1140

cuuaccagcg aagaggaguc ccagagauuc aaggggucug aaaacagcca gccugagaag     1200

augucacaag aaccagagau caauaaggac ggagauaggg aagucgagga ggaaaugaaa     1260

aagcacgaga guaacaaugu gggucuguug gaaaaccuca cgaauggcgu uacugccggg     1320

aacggagaca auggccugau uccgcagcgg aaaucccgaa cccccgagaa ccagcaguuu     1380

ccugauaaug aaagcgagga guaccaucgc aucugugaau uacugucuga cuauaaggag     1440

aagcaaaugc caaaauacuc aagugaaaac agcaaucccg agcaggaucu aaagcucaca     1500

uccgaggaag agucucagag acugaaaggu ucggaaaacg ggcagccuga gaagaggagc     1560

caagaaccag agauaaauaa agacggcgau cgggagcuug aaaacuucau ggcuauugag     1620

gaaaugaaga aacaccgcuc cacucaugug ggauuucccg agaauuugac caacggcgcc     1680

acagcaggga acggagacga uggucugauc ccgccuagaa agucaaggac ccccgaaagu     1740

cagcaguucc cagacacgga gaaugaggaa uaucacucug augagcagaa cgacacucaa     1800

aagcaguuuu gcgaggaaca gaauacaggc auucuccacg augaaauccu gauccaugag     1860

gagaaacaga uugaagucgu ggagaagaug aacagcgaac uuucccuguc auguaaaaag     1920

gagaaagaca uauugcacga gaauagcacc cuccgugaag agaucgccau gcugcgguua     1980

gaacuggaca cuaugaagca ucaaucucag cuacgagaga agaaauaccu cgaagauauu     2040

gaguccguaa agaaaagaaa cgacaaucug cuuaaggcuu ugcagcugaa cgagcucaca     2100

auggaugacg auaccgcggu ucuggugauc gacaauggga guggaaugug caaagcaggc     2160

uucgccggug augacgcucc uagggccguc uuucccagca uaguggggcg cccacggcaa     2220

cagggcauga ugggaggcau gcaccagaag gaaucuuaug ucgggaagga ggcacagucc     2280

aaaagaggaa uuuuaacgcu gaaguacccc auggaacacg guaucaucac caacugggau     2340

gacauggaga aaauuuggca ucacacauuc uauaaugaac uuaggguggc cccugaggag     2400

cauccaguuu ugcucacuga agcuacccug aacccgaagg ccaaucgcga gaaaaugaca     2460

caaaucaugu ucgaaacuuu uaacaccccc gcaauguacg uggcgauuca ggcuguacua     2520

ucacuguaca caaguggccg aaccacuggg auagucaugg auagcggaga cggcgugacg     2580

cacacaguuc cuaucuauga ggguaaugcc cucccacaug caacccugcg gcuugauuug     2640

gccgggcgug aacugcccga cuacuuaaug aagauucuca cugagcacgg cuauagauuc     2700

accacaaugg cugagaggga aaucgugcgc gacaucaagg agaaacugug uuacgucgcc     2760

cuugauuuug aacaggagau ggcaaccgug gcuucguccu cuagccugga gaagucauau     2820

gaauugccug acggacaggu aauuacuaua ggcaacgagc gguucagaug cccagaagcc     2880

cucuuucaac ccugcuuccu ggggauggag aguuguggaa uccacgaaac aacguuuaac     2940

uccauuauga aaucugaugu ggacaucagg aaggaucuau acaccaauac uguucugagc     3000

ggcgguacaa ccauguaucc ggggauggcg caucgaaugc agaaagagau ugccgcucuc     3060

gcaccuucca ugaugaagau ccgcauaauc gccccaccca aacggaagua cucagucugg     3120

gugggaggca gcauucuggc uagucuuucu acauuccagc agauguggau cuccaagcaa     3180

gaguacgacg aaagcggucc uucgauugug cacagaaaau gcuuguga                  3228


<210>  3168
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       POTEF__Homo_sapiens__CCDS46409.1

<400>  3168
augguggugg agguggacag caugcccgcc gccagcagcg ugaagaagcc cuucggccug       60

agaagcaaga ugggcaagug gugcugcaga ugcuuccccu gcugcagaga gagcggcaag      120

agcaacgugg gcaccagcgg cgaccacgac gacagcgcca ugaagacccu gagaagcaag      180

augggcaagu ggugcagaca cugcuucccc ugcugcagag gcagcggcaa gagcaacgug      240

ggcgccagcg gcgaccacga cgacagcgcc augaagaccc ugagaaacaa gaugggcaag      300

uggugcugcc acugcuuccc cugcugcaga ggcagcagca agagcaaggu gggcgccugg      360

ggcgacuacg acgacagcgc cuucauggag cccagauacc acgugagagg cgaggaccug      420

gacaagcugc acagagccgc cugguggggc aaggugccca gaaaggaccu gaucgugaug      480

cugagagaca ccgacgugaa caagcaggac aagcagaaga gaaccgcccu gcaccuggcc      540

agcgccaacg gcaacagcga gguggugaag cugcugcugg acagaagaug ccagcugaac      600

gugcuggaca acaagaagag aaccgcccug aucaaggccg ugcagugcca ggaggacgag      660

ugcgcccuga ugcugcugga gcacggcacc gaccccaaca uccccgacga guacggcaac      720

accacccugc acuacgccau cuacaacgag gacaagcuga uggccaaggc ccugcugcug      780

uacggcgccg acaucgagag caagaacaag cacggccuga ccccccugcu gcugggcgug      840

cacgagcaga agcagcaggu ggugaaguuc cugaucaaga agaaggccaa ccugaacgcc      900

cuggacagau acggcagaac cgcccugauc cuggccgugu gcugcggcag cgccagcauc      960

gugagccugc ugcuggagca gaacaucgac gugagcagcc aggaccugag cggccagacc     1020

gccagagagu acgccgugag cagccaccac cacgugaucu gccagcugcu gagcgacuac     1080

aaggagaagc agaugcugaa gaucagcagc gagaacagca accccgagca ggaccugaag     1140

cugaccagcg aggaggagag ccagagauuc aagggcagcg agaacagcca gcccgagaag     1200

augagccagg agcccgagau caacaaggac ggcgacagag agguggagga ggagaugaag     1260

aagcacgaga gcaacaacgu gggccugcug gagaaccuga ccaacggcgu gaccgccggc     1320

aacggcgaca acggccugau cccccagaga aagagcagaa cccccgagaa ccagcaguuc     1380

cccgacaacg agagcgagga guaccacaga aucugcgagc ugcugagcga cuacaaggag     1440

aagcagaugc ccaaguacag cagcgagaac agcaaccccg agcaggaccu gaagcugacc     1500

agcgaggagg agagccagag acugaagggc agcgagaacg gccagcccga gaagagaagc     1560

caggagcccg agaucaacaa ggacggcgac agagagcugg agaacuucau ggccaucgag     1620

gagaugaaga agcacagaag cacccacgug ggcuuccccg agaaccugac caacggcgcc     1680

accgccggca acggcgacga cggccugauc ccccccagaa agagcagaac ccccgagagc     1740

cagcaguucc ccgacaccga gaacgaggag uaccacagcg acgagcagaa cgacacccag     1800

aagcaguucu gcgaggagca gaacaccggc auccugcacg acgagauccu gauccacgag     1860

gagaagcaga ucgagguggu ggagaagaug aacagcgagc ugagccugag cugcaagaag     1920

gagaaggaca uccugcacga gaacagcacc cugagagagg agaucgccau gcugagacug     1980

gagcuggaca ccaugaagca ccagagccag cugagagaga agaaguaccu ggaggacauc     2040

gagagcguga agaagagaaa cgacaaccug cugaaggccc ugcagcugaa cgagcugacc     2100

auggacgacg acaccgccgu gcuggugauc gacaacggca gcggcaugug caaggccggc     2160

uucgccggcg acgacgcccc cagagccgug uuccccagca ucgugggcag acccagacag     2220

cagggcauga ugggcggcau gcaccagaag gagagcuacg ugggcaagga ggcccagagc     2280

aagagaggca uccugacccu gaaguacccc auggagcacg gcaucaucac caacugggac     2340

gacauggaga agaucuggca ccacaccuuc uacaacgagc ugagaguggc ccccgaggag     2400

caccccgugc ugcugaccga ggccacccug aaccccaagg ccaacagaga gaagaugacc     2460

cagaucaugu ucgagaccuu caacaccccc gccauguacg uggccaucca ggccgugcug     2520

agccuguaca ccagcggcag aaccaccggc aucgugaugg acagcggcga cggcgugacc     2580

cacaccgugc ccaucuacga gggcaacgcc cugccccacg ccacccugag acuggaccug     2640

gccggcagag agcugcccga cuaccugaug aagauccuga ccgagcacgg cuacagauuc     2700

accaccaugg ccgagagaga gaucgugaga gacaucaagg agaagcugug cuacguggcc     2760

cuggacuucg agcaggagau ggccaccgug gccagcagca gcagccugga gaagagcuac     2820

gagcugcccg acggccaggu gaucaccauc ggcaacgaga gauucagaug ccccgaggcc     2880

cuguuccagc ccugcuuccu gggcauggag agcugcggca uccacgagac caccuucaac     2940

agcaucauga agagcgacgu ggacaucaga aaggaccugu acaccaacac cgugcugagc     3000

ggcggcacca ccauguaccc cggcauggcc cacagaaugc agaaggagau cgccgcccug     3060

gcccccagca ugaugaagau cagaaucauc gcccccccca agagaaagua cagcgugugg     3120

gugggcggca gcauccuggc cagccugagc accuuccagc agauguggau cagcaagcag     3180

gaguacgacg agagcggccc cagcaucgug cacagaaagu gccuguga                  3228


<210>  3169
<211>  3228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       POTEF__Homo_sapiens__CCDS46409.1

<400>  3169
augguggucg agguugacag caugcccgcc gcuuccucug ugaagaaacc uuucggccug       60

agaagcaaga uggggaaaug gugcugucgg ugcuuuccgu guugccgcga auccggaaag      120

ucuaacgugg gcaccagcgg ggaucacgac gauuccgcca ugaaaacacu cagaucuaag      180

augggaaagu ggugucggca uugcuucccc uguugccgcg gcagcgggaa auccaauguc      240

ggagcgagcg gcgaccacga ugacucugcu augaagacgc ugagaaacaa aaugggcaag      300

ugguguugcc auuguuuucc uugcugccgg ggguccagca aaucuaaggu gggagccugg      360

ggcgauuacg acgauuccgc cuucauggag ccccgcuauc acguuagagg ggaagaccuu      420

gauaagcugc aucgggcugc cuggugggga aaagugccuc gcaaggaccu caucgucaug      480

cugagagaua ccgacgugaa uaaacaggac aagcaaaaac ggacagcccu ucaccuggcu      540

agcgcgaacg gcaauucuga gguugugaag cuccugcugg aucgcagaug ucagcucaac      600

guccuggaca auaaaaagcg gaccgcccuu auuaaggcug ugcagugcca ggaagaugag      660

ugugcccuga ugcuccugga gcacgggaca gaccccaaca ucccugauga auacggaaau      720

accacacuuc auuaugcuau uuacaacgag gacaaacuga uggccaaggc gcuccugcug      780

uauggcgccg auaucgaauc caaaaauaag cacggccuca ccccgcugcu ucugggggug      840

caugagcaaa aacagcaggu cguuaaguuu cucauuaaga aaaaggcuaa ccugaaugcc      900

cuugaccgcu acggaagaac ggcucugauc cucgccgugu gcuguggcag cgccuccauc      960

gugucucugc ugcucgagca gaacauugau gucagcuccc aagaccugag cgggcagacc     1020

gcucgggaau augcgguguc uucccaccac cauguuaucu gccagcuucu gagcgauuac     1080

aaagagaagc agaugcucaa aauuucuagc gaaaauucca accccgagca agaccugaaa     1140

cuuacaucug aagaggagag ccagagauuc aagggauccg aaaacagcca gccugagaag     1200

augucucaag aacccgagau caauaaggac ggcgaucgcg aaguggagga ggaaaugaaa     1260

aagcacgagu ccaacaaugu cgggcugcuc gaaaaccuga ccaauggagu gacagccggc     1320

aacggcgaca augggcugau uccucagcgg aaaagcagaa cccccgagaa ccagcaguuu     1380

ccggauaaug aaucugagga guaccaucgc aucugugaac uccuguccga cuauaaggag     1440

aagcaaaugc cuaaauacag cuccgaaaac ucuaaucccg agcaggaucu uaagcugacg     1500

agcgaggaag agucccagcg gcucaaagga ucugaaaacg gccagccuga gaagagaagc     1560

caagaacccg agauuaauaa agacggggau cgcgagcugg aaaacuucau ggcuaucgag     1620

gaaaugaaga aacaccgguc cacacauguu ggauuucccg agaaucugac caacggcgcc     1680

acagccggga acggcgacga uggacuuauc ccuccgagaa agagccgcac ccccgaaucu     1740

cagcaguucc cugacaccga gaaugaggaa uaucacuccg augagcagaa cgacacacaa     1800

aagcaguuuu gcgaggaaca gaauacgggc auucuccacg augaaauccu gauucaugag     1860

gagaaacaga ucgaaguggu cgagaagaug aacagcgaac ugucucucuc cuguaaaaag     1920

gagaaagaca uucugcacga gaauagcacc cuucgggaag agaucgcuau gcugagacuc     1980

gaacuggaca caaugaagca ucaaucucag cugcgcgaga agaaauaccu ugaagauauc     2040

gagagcguga agaaacggaa cgacaaucuc cugaaggccc ugcagcucaa cgagcugacc     2100

auggaugacg auacagcggu ccuugugauu gacaaugggu ccggaaugug caaagcuggc     2160

uucgccgggg augacgcccc cagagcuguu uuuccuagca ucgugggacg gccccgccaa     2220

cagggcauga ugggcgggau gcaccagaag gaaucuuaug ucggaaagga ggcccagucc     2280

aaaagaggca uucugacccu caaguacccg auggaacacg ggaucauuac gaacugggau     2340

gacauggaga aaaucuggca ucacacauuc uauaaugaac ugcggguggc uccugaggag     2400

caucccguuc ugcuuaccga agccacccuc aacccuaagg cgaauagaga gaaaaugaca     2460

caaaucaugu ucgaaaccuu uaacacaccc gccauguacg uggcuauuca ggccguccug     2520

agccuguaca cguccggacg caccacaggc aucgugaugg auucugggga cggagugacc     2580

cacacaguuc cuauuuauga gggcaaugcu cucccccaug ccacccugcg gcuugaucug     2640

gcggggagag aacucccgga cuaccugaug aagauccuga cggagcacgg cuaucgcuuc     2700

accacaaugg ccgagagaga aauuguccgg gacaucaagg agaaacuuug uuacguggcu     2760

cucgauuuug aacaggagau ggccaccgug gcuagcuccu cuagccugga gaaguccuau     2820

gaacugccug acggacaggu cauuacaauc ggcaacgagc gcuucagaug ccccgaagcc     2880

cucuuucaac ccugcuuccu ggggauggag ucuuguggaa uccacgaaac cacguuuaac     2940

agcauuauga aauccgaugu ggacauccgg aaggaucuuu acacaaauac cguucugagc     3000

ggcgggacaa ccauguaucc uggaauggcc caucgcaugc agaaagagau ugcugcgcuc     3060

gccccgucua ugaugaagau cagaauuauc gcucccccua aacggaagua cuccgugugg     3120

gucggcggga gcauccuggc cucucugucc accuuccagc agauguggau uagcaagcaa     3180

gaguacgacg aaucuggccc cuccaucgug caccgcaaau gccuuuga                  3228


<210>  3170
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  POTE__Homo_sapiens__Q86YR6

<400>  3170

Met Val Ala Glu Val Cys Ser Met Pro Thr Ala Ser Thr Val Lys Lys 
1               5                   10                  15      


Pro Phe Asp Leu Arg Ser Lys Met Gly Lys Trp Cys His His Arg Phe 
            20                  25                  30          


Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Met Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Phe Met Lys Met Leu Arg Ser Lys Met Gly Lys Cys 
    50                  55                  60                  


Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Thr Ser Asn Val 
65                  70                  75                  80  


Gly Thr Ser Gly Asp His Glu Asn Ser Phe Met Lys Met Leu Arg Ser 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Gly Lys Ser Asn Val Gly Ala Trp Gly Asp Tyr Asp His Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Ile Arg Arg Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Met Asn Lys Arg Asp Lys Glu Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Gln Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Ile Gln Cys Gln Glu Asp Glu Cys Val Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Ala Asp Arg Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Ala Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys Cys Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Val Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Asn Leu Leu Leu Glu Gln Asn Val Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Leu Lys Val Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Pro Glu Ile Asn Lys Asp Cys Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Ile Lys Lys His Gly Ser Asn Pro Val Gly Leu Pro Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Ala Ser Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Arg Ser Arg Lys Pro Glu Asn Gln Gln Phe Pro Asp Thr Glu 
    450                 455                 460                 


Asn Glu Glu Tyr His Ser Asp Glu Gln Asn Asp Thr Arg Lys Gln Leu 
465                 470                 475                 480 


Ser Glu Glu Gln Asn Thr Gly Ile Ser Gln Asp Glu Ile Leu Thr Asn 
                485                 490                 495     


Lys Gln Lys Gln Ile Glu Val Ala Glu Gln Lys Met Asn Ser Glu Leu 
            500                 505                 510         


Ser Leu Ser His Lys Lys Glu Glu Asp Leu Leu Arg Glu Asn Ser Val 
        515                 520                 525             


Leu Gln Glu Glu Ile Ala Met Leu Arg Leu Glu Leu Asp Glu Thr Lys 
    530                 535                 540                 


His Gln Asn Gln Leu Arg Glu Asn Lys Ile Leu Glu Glu Ile Glu Ser 
545                 550                 555                 560 


Val Lys Glu Lys Thr Asp Lys Leu Leu Arg Ala Met Gln Leu Asn Glu 
                565                 570                 575     


Glu Ala Leu Thr Lys Thr Asn Ile 
            580                 


<210>  3171
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  POTE__Homo_sapiens__CCDS13562.1

<400>  3171
augguggcug agguuuguuc aaugcccacu gccucuacug ugaagaagcc auuugaucuc       60

aggagcaaga ugggcaagug gugccaccac cgcuuccccu gcugcagggg gagcggcaag      120

agcaacaugg gcacuucugg agaccacgac gacuccuuua ugaagaugcu caggagcaag      180

augggcaagu guugccgcca cugcuucccc ugcugcaggg ggagcggcac gagcaacgug      240

ggcacuucug gagaccauga aaacuccuuu augaagaugc ucaggagcaa gaugggcaag      300

uggugcuguc acugcuuccc cugcugcagg gggagcggca agagcaacgu gggcgcuugg      360

ggagacuacg accacagcgc cuucauggag ccgagguacc acauccgucg agaagaucug      420

gacaagcucc acagagcugc cugguggggu aaagucccca gaaaggaucu caucgucaug      480

cucagggaca cugacaugaa caagagggac aaggaaaaga ggacugcucu acauuuggcc      540

ucugccaaug gaaauucaga aguaguacaa cuccugcugg acagacgaug ucaacuuaau      600

guccuugaca acaaaaaaag gacagcucug auaaaggcca uacaaugcca ggaagaugaa      660

uguguguuaa uguugcugga acauggcgcu gaucgaaaua uuccagauga guauggaaau      720

accgcucuac acuaugcuau cuacaaugaa gauaaauuaa uggccaaagc acugcucuua      780

uauggugcug auauugaauc aaaaaacaag uguggccuca caccacuuuu gcuuggcgua      840

caugaacaaa aacagcaagu ggugaaauuu uuaaucaaga aaaaagcuaa uuuaaaugua      900

cuugauagau auggaagaac ugcccucaua cuugcuguau guuguggauc agcaaguaua      960

gucaaucuuc uacuugagca aaauguugau guaucuucuc aagaucuauc uggacagacg     1020

gccagagagu augcuguuuc uagucaucau cauguaauuu gugaauuacu uucugacuau     1080

aaagaaaaac agaugcuaaa aaucucuucu gaaaacagca auccagaaca agacuuaaag     1140

cugacaucag aggaagaguc acaaaggcuu aaagucagug aaaauagcca gccagagaaa     1200

augucucaag aaccagaaau aaauaaggac ugugauagag agguugaaga agaaauaaag     1260

aagcauggaa guaauccugu gggauuacca gaaaaccuga cuaauggugc cagugcuggc     1320

aauggugaug auggauuaau uccacaaagg aggagcagaa aaccugaaaa ucagcaauuu     1380

ccugacacug agaaugaaga guaucacagu gaugaacaaa augauacccg gaaacaacuu     1440

ucugaagaac agaacacugg aauaucacaa gaugagauuc ugacuaauaa acaaaagcag     1500

auagaagugg cugaacagaa aaugaauucu gagcuuucuc uuagucauaa gaaagaagaa     1560

gaucucuugc gugaaaacag cguguugcag gaagaaauug ccaugcuaag acuggaacua     1620

gaugaaacaa aacaucagaa ccagcuaagg gaaaauaaaa uuuuggagga aauugaaagu     1680

gugaaagaaa agacugauaa acuucuaagg gcuaugcaau ugaaugaaga agcauuaacg     1740

aaaaccaaua uuuaa                                                      1755


<210>  3172
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       POTE__Homo_sapiens__CCDS13562.1

<400>  3172
augguggccg aggucugcag caugcccacc gccuccaccg ugaagaagcc guucgaccug       60

cgcagcaaga ugggcaagug gugccaccac cgguuccccu gcugccgcgg guccggcaag      120

agcaacaugg ggacguccgg cgaccacgac gacagcuuca ugaagaugcu ccgguccaag      180

auggggaagu gcugccgcca cugcuucccc ugcugccggg gcagcggcac cuccaacgug      240

gggaccagcg gcgaccacga gaacuccuuc augaagaugc ugcgcagcaa gauggggaag      300

uggugcugcc acugcuuccc cugcugccgg ggcuccggca agagcaacgu cggggcgugg      360

ggcgacuacg accacuccgc cuucauggag ccgcgcuacc acauccggcg cgaggaccug      420

gacaagcucc accgggccgc cugguggggg aaggugcccc gcaaggaccu gaucgugaug      480

cugcgggaca ccgacaugaa caagcgcgac aaggagaagc ggacggcccu ccaccuggcg      540

agcgccaacg gcaacuccga ggucgugcag cugcuccugg accgccggug ccagcugaac      600

gugcucgaca acaagaagcg caccgcccug aucaaggcca uccagugcca ggaggacgag      660

ugcguccuga ugcuccugga gcacggggcg gaccggaaca uccccgacga guacggcaac      720

accgcccugc acuacgccau cuacaacgag gacaagcuca uggccaaggc ccugcugcuc      780

uacggcgcgg acaucgagag caagaacaag ugcgggcuga cgccccugcu ccugggcgug      840

cacgagcaga agcagcaggu cgugaaguuc cugaucaaga agaaggccaa ccucaacgug      900

cuggaccgcu acgggcggac cgcccugauc cucgccgugu gcugcggcuc cgccagcauc      960

gucaaccugc ugcucgagca gaacguggac gugagcuccc aggaccugag cgggcagacc     1020

gcgcgcgagu acgccgucuc cagccaccac cacgugaucu gcgagcugcu cuccgacuac     1080

aaggagaagc agaugcugaa gaucagcucc gagaacagca acccggagca ggaccugaag     1140

cucaccuccg aggaggagag ccagcgccug aagguguccg agaacagcca gcccgagaag     1200

augucccagg agcccgagau caacaaggac ugcgaccggg aggucgagga ggagaucaag     1260

aagcacggca gcaaccccgu gggccugccg gagaaccuca ccaacggggc cuccgccggc     1320

aacggggacg acggccugau cccccagcgc cggagccgca agcccgagaa ccagcaguuc     1380

cccgacacgg agaacgagga guaccacucc gacgagcaga acgacacccg gaagcagcug     1440

agcgaggagc agaacaccgg gaucucccag gacgagaucc ucaccaacaa gcagaagcag     1500

aucgaggugg ccgagcagaa gaugaacagc gagcugagcc ugucccacaa gaaggaggag     1560

gaccuccugc gcgagaacag cguccugcag gaggagaucg cgaugcugcg gcucgagcug     1620

gacgagacga agcaccagaa ccagcugcgc gagaacaaga uccucgagga gaucgagucc     1680

gugaaggaga agaccgacaa gcugcugcgg gccaugcagc ucaacgagga ggcccugacc     1740

aagaccaaca ucuga                                                      1755


<210>  3173
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       POTE__Homo_sapiens__CCDS13562.1

<400>  3173
auggucgccg aggucugcuc caugcccacc gccuccaccg ucaagaagcc cuucgaccuc       60

cgcuccaaga ugggcaagug gugccaccac cgcuuccccu gcugccgcgg cuccggcaag      120

uccaacaugg gcaccuccgg cgaccacgac gacuccuuca ugaagaugcu ccgcuccaag      180

augggcaagu gcugccgcca cugcuucccc ugcugccgcg gcuccggcac cuccaacguc      240

ggcaccuccg gcgaccacga gaacuccuuc augaagaugc uccgcuccaa gaugggcaag      300

uggugcugcc acugcuuccc cugcugccgc ggcuccggca aguccaacgu cggcgccugg      360

ggcgacuacg accacuccgc cuucauggag ccccgcuacc acauccgccg cgaggaccuc      420

gacaagcucc accgcgccgc cugguggggc aagguccccc gcaaggaccu caucgucaug      480

cuccgcgaca ccgacaugaa caagcgcgac aaggagaagc gcaccgcccu ccaccucgcc      540

uccgccaacg gcaacuccga ggucguccag cuccuccucg accgccgcug ccagcucaac      600

guccucgaca acaagaagcg caccgcccuc aucaaggcca uccagugcca ggaggacgag      660

ugcguccuca ugcuccucga gcacggcgcc gaccgcaaca uccccgacga guacggcaac      720

accgcccucc acuacgccau cuacaacgag gacaagcuca uggccaaggc ccuccuccuc      780

uacggcgccg acaucgaguc caagaacaag ugcggccuca ccccccuccu ccucggcguc      840

cacgagcaga agcagcaggu cgucaaguuc cucaucaaga agaaggccaa ccucaacguc      900

cucgaccgcu acggccgcac cgcccucauc cucgccgucu gcugcggcuc cgccuccauc      960

gucaaccucc uccucgagca gaacgucgac gucuccuccc aggaccucuc cggccagacc     1020

gcccgcgagu acgccgucuc cucccaccac cacgucaucu gcgagcuccu cuccgacuac     1080

aaggagaagc agaugcucaa gaucuccucc gagaacucca accccgagca ggaccucaag     1140

cucaccuccg aggaggaguc ccagcgccuc aaggucuccg agaacuccca gcccgagaag     1200

augucccagg agcccgagau caacaaggac ugcgaccgcg aggucgagga ggagaucaag     1260

aagcacggcu ccaaccccgu cggccucccc gagaaccuca ccaacggcgc cuccgccggc     1320

aacggcgacg acggccucau cccccagcgc cgcucccgca agcccgagaa ccagcaguuc     1380

cccgacaccg agaacgagga guaccacucc gacgagcaga acgacacccg caagcagcuc     1440

uccgaggagc agaacaccgg caucucccag gacgagaucc ucaccaacaa gcagaagcag     1500

aucgaggucg ccgagcagaa gaugaacucc gagcucuccc ucucccacaa gaaggaggag     1560

gaccuccucc gcgagaacuc cguccuccag gaggagaucg ccaugcuccg ccucgagcuc     1620

gacgagacca agcaccagaa ccagcuccgc gagaacaaga uccucgagga gaucgagucc     1680

gucaaggaga agaccgacaa gcuccuccgc gccaugcagc ucaacgagga ggcccucacc     1740

aagaccaaca ucuga                                                      1755


<210>  3174
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       POTE__Homo_sapiens__CCDS13562.1

<400>  3174
augguggccg aggucugcag caugcccacc gcuuccacag uuaagaaacc uuucgaccug       60

agaucuaaga ugggcaaaug gugucaccau agguuuccau gcugucgggg gucaggaaag      120

aguaacaugg guacuagcgg cgaucacgac gauuccuuca ugaaaaugcu ccgcucuaag      180

auggggaagu gcugucgaca uugcuuuccg uguugccgug gaucgggcac gucaaaugug      240

gguaccagcg gggaccacga aaacaguuuc augaaaaugc uuagauccaa gaugggaaaa      300

ugguguugcc auuguuuucc cugcugcagg ggcucuggca agagcaaugu aggggcaugg      360

ggagauuacg accacuccgc cuucauggag ccucgguauc acauccgcag agaagaucug      420

gacaaauugc auagggcggc uugguggggu aaggugccac ggaaggauuu aauugucaug      480

cugcgcgaca cagauaugaa caaacgagac aaggagaaaa gaacugcccu acaccucgca      540

ucagccaaug gcaacaguga agugguucag cugcuucugg auaggcggug ucaauugaau      600

gugcucgaca acaagaaacg uaccgcucug auaaaggcaa uccagugcca ggaggacgag      660

uguguccuga ugcucuuaga acauggggcc gaucgcaaua uucccgacga guacggaaac      720

acagcucugc acuaugccau cuacaaugaa gauaaacuua uggcgaaggc auugcugcua      780

uauggcgccg acauugagag caagaacaaa ugcggucuca ccccucugcu ucugggggug      840

cacgagcaga agcaacaggu aguuaaauuu uugaucaaga aaaaggcuaa ucucaacgug      900

cuggauagau acggaaggac ugccuuaaua cuggcagucu guugcggcuc ugcuuccauc      960

gugaaucucc uucuggaaca gaacguggac gucucaagcc aggauuugag uggccaaaca     1020

gcccgggagu augcgguuuc uucccaucac caugugauuu gugaacuacu gagcgacuac     1080

aaggagaaac agaugcucaa gaucucgucu gaaaacucca auccagagca ggaucugaaa     1140

cuuaccucag aggaagagag ucagcgacug aagguaagcg aaaacuccca acccgagaaa     1200

augucucagg aaccugagau uaauaaggac ugcgaucgcg agguggaaga ggaaaucaag     1260

aaacacggga gcaacccagu cggauugccg gagaaucuca cgaacggugc cucagcaggc     1320

aauggggacg acggacugau accccagaga aggagucgga agccugaaaa ccaacaguuc     1380

ccagauacug agaaugagga auaccauucc gacgagcaga acgauacccg caaacaguua     1440

agcgaagaac aaaauacagg cauuucucag gacgagaucc ugacuaacaa gcagaaacag     1500

auugaagugg cugagcaaaa gaugaauagu gaacuaucac ucagccacaa gaaagaggaa     1560

gaucugcuua gagagaacuc cguuuugcag gaggaaaucg ccaugcugag gcucgagcug     1620

gacgaaacca agcaccagaa ucagcuucgu gagaacaaaa uccuggaaga gauugagucu     1680

gugaaggaga aaacagauaa guugcuccgg gcuaugcaac ugaacgagga agccuuaacc     1740

aaaacgaaua uauga                                                      1755


<210>  3175
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       POTE__Homo_sapiens__CCDS13562.1

<400>  3175
augguggccg aggugugcag caugcccacc gccagcaccg ugaagaagcc cuucgaccug       60

agaagcaaga ugggcaagug gugccaccac agauuccccu gcugcagagg cagcggcaag      120

agcaacaugg gcaccagcgg cgaccacgac gacagcuuca ugaagaugcu gagaagcaag      180

augggcaagu gcugcagaca cugcuucccc ugcugcagag gcagcggcac cagcaacgug      240

ggcaccagcg gcgaccacga gaacagcuuc augaagaugc ugagaagcaa gaugggcaag      300

uggugcugcc acugcuuccc cugcugcaga ggcagcggca agagcaacgu gggcgccugg      360

ggcgacuacg accacagcgc cuucauggag cccagauacc acaucagaag agaggaccug      420

gacaagcugc acagagccgc cugguggggc aaggugccca gaaaggaccu gaucgugaug      480

cugagagaca ccgacaugaa caagagagac aaggagaaga gaaccgcccu gcaccuggcc      540

agcgccaacg gcaacagcga gguggugcag cugcugcugg acagaagaug ccagcugaac      600

gugcuggaca acaagaagag aaccgcccug aucaaggcca uccagugcca ggaggacgag      660

ugcgugcuga ugcugcugga gcacggcgcc gacagaaaca uccccgacga guacggcaac      720

accgcccugc acuacgccau cuacaacgag gacaagcuga uggccaaggc ccugcugcug      780

uacggcgccg acaucgagag caagaacaag ugcggccuga ccccccugcu gcugggcgug      840

cacgagcaga agcagcaggu ggugaaguuc cugaucaaga agaaggccaa ccugaacgug      900

cuggacagau acggcagaac cgcccugauc cuggccgugu gcugcggcag cgccagcauc      960

gugaaccugc ugcuggagca gaacguggac gugagcagcc aggaccugag cggccagacc     1020

gccagagagu acgccgugag cagccaccac cacgugaucu gcgagcugcu gagcgacuac     1080

aaggagaagc agaugcugaa gaucagcagc gagaacagca accccgagca ggaccugaag     1140

cugaccagcg aggaggagag ccagagacug aaggugagcg agaacagcca gcccgagaag     1200

augagccagg agcccgagau caacaaggac ugcgacagag agguggagga ggagaucaag     1260

aagcacggca gcaaccccgu gggccugccc gagaaccuga ccaacggcgc cagcgccggc     1320

aacggcgacg acggccugau cccccagaga agaagcagaa agcccgagaa ccagcaguuc     1380

cccgacaccg agaacgagga guaccacagc gacgagcaga acgacaccag aaagcagcug     1440

agcgaggagc agaacaccgg caucagccag gacgagaucc ugaccaacaa gcagaagcag     1500

aucgaggugg ccgagcagaa gaugaacagc gagcugagcc ugagccacaa gaaggaggag     1560

gaccugcuga gagagaacag cgugcugcag gaggagaucg ccaugcugag acuggagcug     1620

gacgagacca agcaccagaa ccagcugaga gagaacaaga uccuggagga gaucgagagc     1680

gugaaggaga agaccgacaa gcugcugaga gccaugcagc ugaacgagga ggcccugacc     1740

aagaccaaca ucuga                                                      1755


<210>  3176
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       POTE__Homo_sapiens__CCDS13562.1

<400>  3176
augguggccg aggucugcag caugcccacc gcuuccacag uuaagaaacc uuucgaccug       60

agaucuaaga ugggcaaaug gugucaccau cgguuuccgu gcugucgcgg gagcggaaag      120

uccaacaugg gcacgucugg ggaucacgac gauagcuuca ugaaaaugcu cagauccaag      180

augggaaagu gcugucggca uugcuuuccc uguugccgcg gcucugggac cagcaaugug      240

ggaacauccg gcgaccacga aaacagcuuc augaaaaugc ugagaucuaa gaugggcaaa      300

ugguguugcc auuguuuucc uugcugccgg ggguccggaa agagcaaugu gggcgccugg      360

ggagauuacg accacucugc guucauggag ccccgcuauc acaucagacg ggaagaucuu      420

gacaaacugc aucgcgcugc cugguggggg aaggucccua gaaaggaucu cauugugaug      480

cugcgggaca ccgauaugaa caaacgcgac aaggagaaaa gaacagcccu ucaccuggcu      540

uccgccaaug gcaacagcga aguugugcag cuccugcugg aucggcgcug ucaacucaau      600

guccuggaca acaagaaaag aaccgcucuu aucaaggcca uucagugcca ggaggacgag      660

ugugugcuga ugcuccugga acauggggcg gaucggaaua uccccgacga guacggaaac      720

acagcccuuc acuaugcuau uuacaaugaa gauaaacuga uggccaaggc ucuccugcug      780

uauggcgccg acaucgaguc uaagaacaaa ugcggccuca ccccucugcu ucuggggguu      840

cacgagcaga agcaacaggu ggucaaauuu cucaucaaga aaaaggcgaa ucugaacgug      900

cuugauagau acggacgcac ggcccugauu cucgcugugu guugcggcuc cgccagcauc      960

gucaaucugc ugcucgaaca gaacguugac guguccucuc aggaucugag cgggcaaacc     1020

gcucgggagu augccguguc cagccaucac caugucauuu gugaacuucu gucugacuac     1080

aaggagaaac agaugcucaa gaucuccagc gaaaacucua auccggagca ggaucugaaa     1140

cuuacaagcg aggaagaguc ccagagacug aaggugucug aaaacagcca acccgagaaa     1200

augucccagg aaccugagau uaauaaggac ugcgaucgcg agguugaaga ggaaaucaag     1260

aaacacggaa gcaaccccgu gggccucccu gagaaucuga ccaacggggc cucugcugga     1320

aauggcgacg acggccugau uccccagcgg agaucccgca agccggaaaa ccaacaguuc     1380

ccugauacag agaaugagga auaccauagc gacgagcaga acgauacccg gaaacagcuc     1440

ucugaagaac aaaauacggg gaucucccag gacgagaucc ugacaaacaa gcagaaacag     1500

auugaagucg cggagcaaaa gaugaauagc gaacuuuccc ugucucacaa gaaagaggaa     1560

gaucuccuga gagagaacag cgugcugcag gaggaaaucg ccaugcuucg ccucgagcug     1620

gacgaaacca agcaccagaa ucagcugcgg gagaacaaaa uucucgaaga gaucgagucc     1680

guuaaggaga aaacagauaa gcugcuuaga gcuaugcaac ugaacgagga agcccucacc     1740

aaaaccaaua uuuga                                                      1755


<210>  3177
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRAME__Homo_sapiens__A0A024R1E6

<400>  3177

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  3178
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRAME__Homo_sapiens__EAW59519

<400>  3178
auggaacgaa ggcguuugug ggguuccauu cagagccgau acaucagcau gagugugugg       60

acaagcccac ggagacuugu ggagcuggca gggcagagcc ugcugaagga ugaggcccug      120

gccauugccg cccuggaguu gcugcccagg gagcucuucc cgccacucuu cauggcagcc      180

uuugacggga gacacagcca gacccugaag gcaauggugc aggccuggcc cuucaccugc      240

cucccucugg gagugcugau gaagggacaa caucuucacc uggagaccuu caaagcugug      300

cuugauggac uugaugugcu ccuugcccag gagguucgcc ccaggaggug gaaacuucaa      360

gugcuggauu uacggaagaa cucucaucag gacuucugga cuguaugguc uggaaacagg      420

gccagucugu acucauuucc agagccagaa gcagcucagc ccaugacaaa gaagcgaaaa      480

guagaugguu ugagcacaga ggcagagcag cccuucauuc caguagaggu gcucguagac      540

cuguuccuca aggaaggugc cugugaugaa uuguucuccu accucauuga gaaagugaag      600

cgaaagaaaa auguacuacg ccugugcugu aagaagcuga agauuuuugc aaugcccaug      660

caggauauca agaugauccu gaaaauggug cagcuggacu cuauugaaga uuuggaagug      720

acuuguaccu ggaagcuacc caccuuggcg aaauuuucuc cuuaccuggg ccagaugauu      780

aaucugcgua gacuccuccu cucccacauc caugcaucuu ccuacauuuc cccggagaag      840

gaagagcagu auaucgccca guucaccucu caguuccuca gucugcagug ccugcaggcu      900

cucuaugugg acucuuuauu uuuccuuaga ggccgccugg aucaguugcu caggcacgug      960

augaaccccu uggaaacccu cucaauaacu aacugccggc uuucggaagg ggaugugaug     1020

caucuguccc agagucccag cgucagucag cuaagugucc ugagucuaag uggggucaug     1080

cugaccgaug uaagucccga gccccuccaa gcucugcugg agagagccuc ugccacccuc     1140

caggaccugg ucuuugauga gugugggauc acggaugauc agcuccuugc ccuccugccu     1200

ucccugagcc acugcuccca gcuuacaacc uuaagcuucu acgggaauuc caucuccaua     1260

ucugccuugc agagucuccu gcagcaccuc aucgggcuga gcaaucugac ccacgugcug     1320

uauccugucc cccuggagag uuaugaggac auccauggua cccuccaccu ggagaggcuu     1380

gccuaucugc augccaggcu cagggaguug cugugugagu uggggcggcc cagcaugguc     1440

uggcuuagug ccaaccccug uccucacugu ggggacagaa ccuucuauga cccggagccc     1500

auccugugcc ccuguuucau gccuaacuag                                      1530


<210>  3179
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRAME__Homo_sapiens__EAW59519

<400>  3179
auggagcgcc ggcgccugug gggcagcauc cagucccggu acaucagcau guccgugugg       60

accagccccc gccggcucgu cgagcuggcc gggcaguccc ugcucaagga cgaggcccug      120

gcgaucgccg cccuggagcu ccugccgcgc gagcuguucc cgccccucuu cauggccgcc      180

uucgacggcc ggcacagcca gacccugaag gcgauggugc aggccuggcc cuucacgugc      240

cugccccucg gggugcugau gaagggccag caccuccacc uggagaccuu caaggccguc      300

cuggacgggc uggacgugcu ccuggcccag gaggugcgcc cccggcgcug gaagcugcag      360

guccucgacc ugcggaagaa cucccaccag gacuucugga ccguguggag cggcaaccgc      420

gcgucccugu acagcuuccc cgagcccgag gccgcccagc cgaugaccaa gaagcggaag      480

guggacggcc ucuccacgga ggccgagcag cccuucaucc ccgucgaggu gcugguggac      540

cuguuccuca aggagggggc cugcgacgag cuguucagcu accugaucga gaaggucaag      600

cgcaagaaga acgugcuccg gcugugcugc aagaagcuga agaucuucgc gaugcccaug      660

caggacauca agaugauccu caagauggug cagcuggacu ccaucgagga ccuggaggug      720

accugcaccu ggaagcuccc gacccuggcc aaguucagcc ccuaccuggg ccagaugauc      780

aaccuccgcc ggcugcugcu cucccacauc cacgccagcu ccuacaucag ccccgagaag      840

gaggagcagu acaucgccca guucacgucc caguuccuga gccugcagug ccuccaggcc      900

cuguacgucg acagccuguu cuuccuccgc gggcggcugg accagcugcu gcgccacgug      960

augaaccccc ucgagacccu guccaucacc aacugccggc ugagcgaggg cgacgucaug     1020

caccucuccc agagcccguc cgugagccag cuguccgugc ugagccucuc cggggucaug     1080

cugaccgacg ugagccccga gccccugcag gcgcuccugg agcgcgccuc cgccacgcug     1140

caggaccucg uguucgacga gugcggcauc accgacgacc agcugcuggc ccuccugccc     1200

agccuguccc acugcagcca gcucaccacc cuguccuucu acggcaacag caucuccauc     1260

agcgcccugc agucccuccu gcagcaccug aucgggcuca gcaaccugac gcacguccug     1320

uacccggugc cccucgagag cuacgaggac auccacggca cccugcaccu ggagcgccuc     1380

gcguaccugc acgcccggcu gcgcgagcuc cugugcgagc uggggcggcc cuccaugguc     1440

uggcucagcg ccaaccccug cccgcacugc ggcgaccgca ccuucuacga ccccgagccc     1500

auccugugcc ccugcuucau gccgaacuga                                      1530


<210>  3180
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRAME__Homo_sapiens__EAW59519

<400>  3180
auggagcgcc gccgccucug gggcuccauc cagucccgcu acaucuccau guccgucugg       60

accucccccc gccgccucgu cgagcucgcc ggccaguccc uccucaagga cgaggcccuc      120

gccaucgccg cccucgagcu ccucccccgc gagcucuucc ccccccucuu cauggccgcc      180

uucgacggcc gccacuccca gacccucaag gccauggucc aggccuggcc cuucaccugc      240

cucccccucg gcguccucau gaagggccag caccuccacc ucgagaccuu caaggccguc      300

cucgacggcc ucgacguccu ccucgcccag gagguccgcc cccgccgcug gaagcuccag      360

guccucgacc uccgcaagaa cucccaccag gacuucugga ccgucugguc cggcaaccgc      420

gccucccucu acuccuuccc cgagcccgag gccgcccagc ccaugaccaa gaagcgcaag      480

gucgacggcc ucuccaccga ggccgagcag cccuucaucc ccgucgaggu ccucgucgac      540

cucuuccuca aggagggcgc cugcgacgag cucuucuccu accucaucga gaaggucaag      600

cgcaagaaga acguccuccg ccucugcugc aagaagcuca agaucuucgc caugcccaug      660

caggacauca agaugauccu caagaugguc cagcucgacu ccaucgagga ccucgagguc      720

accugcaccu ggaagcuccc cacccucgcc aaguucuccc ccuaccucgg ccagaugauc      780

aaccuccgcc gccuccuccu cucccacauc cacgccuccu ccuacaucuc ccccgagaag      840

gaggagcagu acaucgccca guucaccucc caguuccucu cccuccagug ccuccaggcc      900

cucuacgucg acucccucuu cuuccuccgc ggccgccucg accagcuccu ccgccacguc      960

augaaccccc ucgagacccu cuccaucacc aacugccgcc ucuccgaggg cgacgucaug     1020

caccucuccc agucccccuc cgucucccag cucuccgucc ucucccucuc cggcgucaug     1080

cucaccgacg ucucccccga gccccuccag gcccuccucg agcgcgccuc cgccacccuc     1140

caggaccucg ucuucgacga gugcggcauc accgacgacc agcuccucgc ccuccucccc     1200

ucccucuccc acugcuccca gcucaccacc cucuccuucu acggcaacuc caucuccauc     1260

uccgcccucc agucccuccu ccagcaccuc aucggccucu ccaaccucac ccacguccuc     1320

uaccccgucc cccucgaguc cuacgaggac auccacggca cccuccaccu cgagcgccuc     1380

gccuaccucc acgcccgccu ccgcgagcuc cucugcgagc ucggccgccc cuccaugguc     1440

uggcucuccg ccaaccccug cccccacugc ggcgaccgca ccuucuacga ccccgagccc     1500

auccucugcc ccugcuucau gcccaacuga                                      1530


<210>  3181
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRAME__Homo_sapiens__EAW59519

<400>  3181
auggagagaa ggcggcugug gggcagcauc cagucccgcu acauuucuau gucagugugg       60

accagucccc gacgucucgu cgaacuugcc gggcaaagcc uguugaagga cgaggcuuua      120

gcaauagccg cgcuggaacu acucccuaga gagcuguucc caccgcuuuu uauggcugcc      180

uucgauggaa ggcacuccca gacacugaaa gcaaugguuc aggccuggcc cuuuacuugc      240

uugccucucg gugugcugau gaagggccag caucugcacc ucgaaacguu caaagcugua      300

uuagacgggc uggaugugcu uuuggcacaa gagguccggc cacgcagaug gaagcuacag      360

gugcuggacc ucaggaaaaa cucucaucag gauuuuugga ccguuugguc gggaaaucgg      420

gccucacugu auagcuuccc cgagccugaa gcugcccagc caaugacaaa gaagcgcaaa      480

guggacggcc uuaguacuga ggcggaacaa cccuuuaucc cugucgaggu gcugguagau      540

uuguuccuca aggagggugc augugacgaa cuguuuuccu acuuaauuga gaaaguuaag      600

cgaaagaaaa acgugcugag acucugcugu aagaaacuua agaucuucgc caugccaaug      660

caggauauua aaaugauccu gaagaugguc caguuggacu cuauagaaga ucuagaggug      720

accugcacau ggaaacugcc gacccucgcu aaguuuagcc ccuaucuggg gcagaugauc      780

aaucuuaggc ggcuguugcu cucccacauu caugccucaa guuacaucag cccugaaaaa      840

gaggagcaau auauugcaca guucacuucu caguuucugu ccuuacaaug ucugcaggcu      900

cuauacgugg acucacucuu cuuccugcgu ggacgccuug aucaguugcu gagacacguc      960

augaacccac ucgaaacacu gagcaucacc aauugcaggc uuagugaggg cgacguuaug     1020

caccugucuc agucccccag cgugucgcaa uugucuguac ucucccuguc aggcgugaug     1080

uuaacggacg ucaguccuga accacugcag gcccuacucg agcgggcgag cgccacucug     1140

caggaucuug uguuugacga augugggaua accgaugacc aguugcuggc acuccugccc     1200

uccuuaucuc auugcagcca acugacaacu cuuucauucu auggaaacag uauuuccauc     1260

agcgcuuugc agucucuccu gcagcaccua auuggucugu caaaucucac ccauguucug     1320

uacccggugc cucuugagag uuacgaggau auccacggca cauugcaccu ggaacgauua     1380

gccuaucucc augcucgccu gagagagcuu cugugugaau uggggaggcc cagcaugguc     1440

uggcucuccg ccaacccaug cccucacugu ggagaccgga ccuuuuacga ucccgagcca     1500

auccugugcc ccugcuucau gccuaauuga                                      1530


<210>  3182
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRAME__Homo_sapiens__EAW59519

<400>  3182
auggagagaa gaagacugug gggcagcauc cagagcagau acaucagcau gagcgugugg       60

accagcccca gaagacuggu ggagcuggcc ggccagagcc ugcugaagga cgaggcccug      120

gccaucgccg cccuggagcu gcugcccaga gagcuguucc ccccccuguu cauggccgcc      180

uucgacggca gacacagcca gacccugaag gccauggugc aggccuggcc cuucaccugc      240

cugccccugg gcgugcugau gaagggccag caccugcacc uggagaccuu caaggccgug      300

cuggacggcc uggacgugcu gcuggcccag gaggugagac ccagaagaug gaagcugcag      360

gugcuggacc ugagaaagaa cagccaccag gacuucugga ccguguggag cggcaacaga      420

gccagccugu acagcuuccc cgagcccgag gccgcccagc ccaugaccaa gaagagaaag      480

guggacggcc ugagcaccga ggccgagcag cccuucaucc ccguggaggu gcugguggac      540

cuguuccuga aggagggcgc cugcgacgag cuguucagcu accugaucga gaaggugaag      600

agaaagaaga acgugcugag acugugcugc aagaagcuga agaucuucgc caugcccaug      660

caggacauca agaugauccu gaagauggug cagcuggaca gcaucgagga ccuggaggug      720

accugcaccu ggaagcugcc cacccuggcc aaguucagcc ccuaccuggg ccagaugauc      780

aaccugagaa gacugcugcu gagccacauc cacgccagca gcuacaucag ccccgagaag      840

gaggagcagu acaucgccca guucaccagc caguuccuga gccugcagug ccugcaggcc      900

cuguacgugg acagccuguu cuuccugaga ggcagacugg accagcugcu gagacacgug      960

augaaccccc uggagacccu gagcaucacc aacugcagac ugagcgaggg cgacgugaug     1020

caccugagcc agagccccag cgugagccag cugagcgugc ugagccugag cggcgugaug     1080

cugaccgacg ugagccccga gccccugcag gcccugcugg agagagccag cgccacccug     1140

caggaccugg uguucgacga gugcggcauc accgacgacc agcugcuggc ccugcugccc     1200

agccugagcc acugcagcca gcugaccacc cugagcuucu acggcaacag caucagcauc     1260

agcgcccugc agagccugcu gcagcaccug aucggccuga gcaaccugac ccacgugcug     1320

uaccccgugc cccuggagag cuacgaggac auccacggca cccugcaccu ggagagacug     1380

gccuaccugc acgccagacu gagagagcug cugugcgagc ugggcagacc cagcauggug     1440

uggcugagcg ccaaccccug cccccacugc ggcgacagaa ccuucuacga ccccgagccc     1500

auccugugcc ccugcuucau gcccaacuga                                      1530


<210>  3183
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRAME__Homo_sapiens__EAW59519

<400>  3183
auggagagac ggcgccugug gggcagcauc caguccagau acauuucuau gagcgugugg       60

accucucccc ggcgccucgu cgaacuggcc gggcaauccc uucugaagga cgaggcucuc      120

gccaucgcgg cucuggaacu ucugccuaga gagcuuuucc cgccccuguu uauggccgcc      180

uucgauggac ggcacagcca gacacugaaa gcuaugguuc aggccuggcc uuuuacgugc      240

cucccccugg gcgugcuuau gaaggggcag caucugcacc ucgaaaccuu caaagcugug      300

cuggacggac uugauguccu gcucgcccaa gaggugcgcc cuagacggug gaagcugcag      360

guucuggacc uccgcaaaaa cucccaucag gauuuuugga cagugugguc uggcaauaga      420

gcgagccugu auuccuuccc cgagccugaa gccgcucagc cgaugaccaa gaagcggaaa      480

gucgacgggc uuagcacaga ggccgaacaa cccuuuauuc cuguggaggu ucugguggau      540

cucuuccuga aggagggagc uugugacgaa cucuuuucuu accugaucga gaaagucaag      600

cgcaaaaaga acgugcucag acugugcugu aagaaacuga agauuuucgc caugcccaug      660

caggauauca aaaugauccu caagauggug cagcuggacu ccauugaaga ucuugagguu      720

accugcacau ggaaacugcc uacccucgcg aaguuuagcc ccuaucuggg ccagaugauc      780

aaucuucggc gccugcuccu gucucacauu caugccucca gcuacaucuc uccggaaaaa      840

gaggagcaau auauugcuca guucacgucc caguuucuga gccuccaaug ucugcaggcc      900

cuuuacgucg acucccuguu cuuccucaga ggccggcugg aucagcugcu uagacacgug      960

augaacccuc ucgaaacccu gucuaucaca aauugccgcc ugagcgaggg ggacgugaug     1020

caccucuccc agagccccuc ugucucccaa cugagcgugc uuucucugag cggaguuaug     1080

cucaccgacg uguccccuga accccugcag gcucugcuug agcgggccuc ugccacacuc     1140

caggaucugg ucuuugacga auguggcauu accgaugacc agcugcucgc ucugcuuccc     1200

agccuguccc auugcagcca acucacgaca cugucuuucu augggaacuc caucagcauc     1260

ucugcgcugc agucccuucu ccagcaccug auuggacuga gcaaucucac ccaugugcug     1320

uacccuguuc cgcuugaguc cuacgaggau auccacggca cacugcaccu cgaaagacug     1380

gccuaucugc augcucgccu ucgggagcuc cugugugaac uggggagacc cucuauggug     1440

uggcucagcg ccaacccuug cccccacugu ggagaccgca ccuuuuacga uccugagccc     1500

auucugugcc cgugcuucau gccuaauuga                                      1530


<210>  3184
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRAME__Homo_sapiens__P78395

<400>  3184

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  3185
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRAME__Homo_sapiens__AAC51160

<400>  3185
auggaacgaa ggcguuugug ggguuccauu cagagccgau acaucagcau gagugugugg       60

acaagcccac ggagacuugu ggagcuggca gggcagagcc ugcugaagga ugaggcccug      120

gccauugccg cccuggaguu gcugcccagg gagcucuucc cgccacucuu cauggcagcc      180

uuugacggga gacacagcca gacccugaag gcaauggugc aggccuggcc cuucaccugc      240

cucccucugg gagugcugau gaagggacaa caucuucacc uggagaccuu caaagcugug      300

cuugauggac uugaugugcu ccuugcccag gagguucgcc ccaggaggug gaaacuucaa      360

gugcuggauu uacggaagaa cucucaucag gacuucugga cuguaugguc uggaaacagg      420

gccagucugu acucauuucc agagccagaa gcagcucagc ccaugacaaa gaagcgaaaa      480

guagaugguu ugagcacaga ggcagagcag cccuucauuc caguagaggu gcucguagac      540

cuguuccuca aggaaggugc cugugaugaa uuguucuccu accucauuga gaaagugaag      600

cgaaagaaaa auguacuacg ccugugcugu aagaagcuga agauuuuugc aaugcccaug      660

caggauauca agaugauccu gaaaauggug cagcuggacu cuauugaaga uuuggaagug      720

acuuguaccu ggaagcuacc caccuuggcg aaauuuucuc cuuaccuggg ccagaugauu      780

aaucugcgua gacuccuccu cucccacauc caugcaucuu ccuacauuuc cccggagaag      840

gaagagcagu auaucgccca guucaccucu caguuccuca gucugcagug ccugcaggcu      900

cucuaugugg acucuuuauu uuuccuuaga ggccgccugg aucaguugcu caggcacgug      960

augaaccccu uggaaacccu cucaauaacu aacugccggc uuucggaagg ggaugugaug     1020

caucuguccc agagucccag cgucagucag cuaagugucc ugagucuaag uggggucaug     1080

cugaccgaug uaagucccga gccccuccaa gcucugcugg agagagccuc ugccacccuc     1140

caggaccugg ucuuugauga gugugggauc acggaugauc agcuccuugc ccuccugccu     1200

ucccugagcc acugcuccca gcuuacaacc uuaagcuucu acgggaauuc caucuccaua     1260

ucugccuugc agagucuccu gcagcaccuc aucgggcuga gcaaucugac ccacgugcug     1320

uauccugucc cccuggagag uuaugaggac auccauggua cccuccaccu ggagaggcuu     1380

gccuaucugc augccaggcu cagggaguug cugugugagu uggggcggcc cagcaugguc     1440

uggcuuagug ccaaccccug uccucacugu ggggacagaa ccuucuauga cccggagccc     1500

auccugugcc ccuguuucau gccuaacuag                                      1530


<210>  3186
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRAME__Homo_sapiens__AAC51160

<400>  3186
auggagcgcc ggcgccugug gggcagcauc cagucccggu acaucagcau guccgugugg       60

accagccccc gccggcucgu cgagcuggcc gggcaguccc ugcucaagga cgaggcccug      120

gcgaucgccg cccuggagcu ccugccgcgc gagcuguucc cgccccucuu cauggccgcc      180

uucgacggcc ggcacagcca gacccugaag gcgauggugc aggccuggcc cuucacgugc      240

cugccccucg gggugcugau gaagggccag caccuccacc uggagaccuu caaggccguc      300

cuggacgggc uggacgugcu ccuggcccag gaggugcgcc cccggcgcug gaagcugcag      360

guccucgacc ugcggaagaa cucccaccag gacuucugga ccguguggag cggcaaccgc      420

gcgucccugu acagcuuccc cgagcccgag gccgcccagc cgaugaccaa gaagcggaag      480

guggacggcc ucuccacgga ggccgagcag cccuucaucc ccgucgaggu gcugguggac      540

cuguuccuca aggagggggc cugcgacgag cuguucagcu accugaucga gaaggucaag      600

cgcaagaaga acgugcuccg gcugugcugc aagaagcuga agaucuucgc gaugcccaug      660

caggacauca agaugauccu caagauggug cagcuggacu ccaucgagga ccuggaggug      720

accugcaccu ggaagcuccc gacccuggcc aaguucagcc ccuaccuggg ccagaugauc      780

aaccuccgcc ggcugcugcu cucccacauc cacgccagcu ccuacaucag ccccgagaag      840

gaggagcagu acaucgccca guucacgucc caguuccuga gccugcagug ccuccaggcc      900

cuguacgucg acagccuguu cuuccuccgc gggcggcugg accagcugcu gcgccacgug      960

augaaccccc ucgagacccu guccaucacc aacugccggc ugagcgaggg cgacgucaug     1020

caccucuccc agagcccguc cgugagccag cuguccgugc ugagccucuc cggggucaug     1080

cugaccgacg ugagccccga gccccugcag gcgcuccugg agcgcgccuc cgccacgcug     1140

caggaccucg uguucgacga gugcggcauc accgacgacc agcugcuggc ccuccugccc     1200

agccuguccc acugcagcca gcucaccacc cuguccuucu acggcaacag caucuccauc     1260

agcgcccugc agucccuccu gcagcaccug aucgggcuca gcaaccugac gcacguccug     1320

uacccggugc cccucgagag cuacgaggac auccacggca cccugcaccu ggagcgccuc     1380

gcguaccugc acgcccggcu gcgcgagcuc cugugcgagc uggggcggcc cuccaugguc     1440

uggcucagcg ccaaccccug cccgcacugc ggcgaccgca ccuucuacga ccccgagccc     1500

auccugugcc ccugcuucau gccgaacuga                                      1530


<210>  3187
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRAME__Homo_sapiens__AAC51160

<400>  3187
auggagcgcc gccgccucug gggcuccauc cagucccgcu acaucuccau guccgucugg       60

accucccccc gccgccucgu cgagcucgcc ggccaguccc uccucaagga cgaggcccuc      120

gccaucgccg cccucgagcu ccucccccgc gagcucuucc ccccccucuu cauggccgcc      180

uucgacggcc gccacuccca gacccucaag gccauggucc aggccuggcc cuucaccugc      240

cucccccucg gcguccucau gaagggccag caccuccacc ucgagaccuu caaggccguc      300

cucgacggcc ucgacguccu ccucgcccag gagguccgcc cccgccgcug gaagcuccag      360

guccucgacc uccgcaagaa cucccaccag gacuucugga ccgucugguc cggcaaccgc      420

gccucccucu acuccuuccc cgagcccgag gccgcccagc ccaugaccaa gaagcgcaag      480

gucgacggcc ucuccaccga ggccgagcag cccuucaucc ccgucgaggu ccucgucgac      540

cucuuccuca aggagggcgc cugcgacgag cucuucuccu accucaucga gaaggucaag      600

cgcaagaaga acguccuccg ccucugcugc aagaagcuca agaucuucgc caugcccaug      660

caggacauca agaugauccu caagaugguc cagcucgacu ccaucgagga ccucgagguc      720

accugcaccu ggaagcuccc cacccucgcc aaguucuccc ccuaccucgg ccagaugauc      780

aaccuccgcc gccuccuccu cucccacauc cacgccuccu ccuacaucuc ccccgagaag      840

gaggagcagu acaucgccca guucaccucc caguuccucu cccuccagug ccuccaggcc      900

cucuacgucg acucccucuu cuuccuccgc ggccgccucg accagcuccu ccgccacguc      960

augaaccccc ucgagacccu cuccaucacc aacugccgcc ucuccgaggg cgacgucaug     1020

caccucuccc agucccccuc cgucucccag cucuccgucc ucucccucuc cggcgucaug     1080

cucaccgacg ucucccccga gccccuccag gcccuccucg agcgcgccuc cgccacccuc     1140

caggaccucg ucuucgacga gugcggcauc accgacgacc agcuccucgc ccuccucccc     1200

ucccucuccc acugcuccca gcucaccacc cucuccuucu acggcaacuc caucuccauc     1260

uccgcccucc agucccuccu ccagcaccuc aucggccucu ccaaccucac ccacguccuc     1320

uaccccgucc cccucgaguc cuacgaggac auccacggca cccuccaccu cgagcgccuc     1380

gccuaccucc acgcccgccu ccgcgagcuc cucugcgagc ucggccgccc cuccaugguc     1440

uggcucuccg ccaaccccug cccccacugc ggcgaccgca ccuucuacga ccccgagccc     1500

auccucugcc ccugcuucau gcccaacuga                                      1530


<210>  3188
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRAME__Homo_sapiens__AAC51160

<400>  3188
auggagagaa ggcggcugug gggcagcauc cagucccgcu acauuucuau gucagugugg       60

accagucccc gacgucucgu cgaacuugcc gggcaaagcc uguugaagga cgaggcuuua      120

gcaauagccg cgcuggaacu acucccuaga gagcuguucc caccgcuuuu uauggcugcc      180

uucgauggaa ggcacuccca gacacugaaa gcaaugguuc aggccuggcc cuuuacuugc      240

uugccucucg gugugcugau gaagggccag caucugcacc ucgaaacguu caaagcugua      300

uuagacgggc uggaugugcu uuuggcacaa gagguccggc cacgcagaug gaagcuacag      360

gugcuggacc ucaggaaaaa cucucaucag gauuuuugga ccguuugguc gggaaaucgg      420

gccucacugu auagcuuccc cgagccugaa gcugcccagc caaugacaaa gaagcgcaaa      480

guggacggcc uuaguacuga ggcggaacaa cccuuuaucc cugucgaggu gcugguagau      540

uuguuccuca aggagggugc augugacgaa cuguuuuccu acuuaauuga gaaaguuaag      600

cgaaagaaaa acgugcugag acucugcugu aagaaacuua agaucuucgc caugccaaug      660

caggauauua aaaugauccu gaagaugguc caguuggacu cuauagaaga ucuagaggug      720

accugcacau ggaaacugcc gacccucgcu aaguuuagcc ccuaucuggg gcagaugauc      780

aaucuuaggc ggcuguugcu cucccacauu caugccucaa guuacaucag cccugaaaaa      840

gaggagcaau auauugcaca guucacuucu caguuucugu ccuuacaaug ucugcaggcu      900

cuauacgugg acucacucuu cuuccugcgu ggacgccuug aucaguugcu gagacacguc      960

augaacccac ucgaaacacu gagcaucacc aauugcaggc uuagugaggg cgacguuaug     1020

caccugucuc agucccccag cgugucgcaa uugucuguac ucucccuguc aggcgugaug     1080

uuaacggacg ucaguccuga accacugcag gcccuacucg agcgggcgag cgccacucug     1140

caggaucuug uguuugacga augugggaua accgaugacc aguugcuggc acuccugccc     1200

uccuuaucuc auugcagcca acugacaacu cuuucauucu auggaaacag uauuuccauc     1260

agcgcuuugc agucucuccu gcagcaccua auuggucugu caaaucucac ccauguucug     1320

uacccggugc cucuugagag uuacgaggau auccacggca cauugcaccu ggaacgauua     1380

gccuaucucc augcucgccu gagagagcuu cugugugaau uggggaggcc cagcaugguc     1440

uggcucuccg ccaacccaug cccucacugu ggagaccgga ccuuuuacga ucccgagcca     1500

auccugugcc ccugcuucau gccuaauuga                                      1530


<210>  3189
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRAME__Homo_sapiens__AAC51160

<400>  3189
auggagagaa gaagacugug gggcagcauc cagagcagau acaucagcau gagcgugugg       60

accagcccca gaagacuggu ggagcuggcc ggccagagcc ugcugaagga cgaggcccug      120

gccaucgccg cccuggagcu gcugcccaga gagcuguucc ccccccuguu cauggccgcc      180

uucgacggca gacacagcca gacccugaag gccauggugc aggccuggcc cuucaccugc      240

cugccccugg gcgugcugau gaagggccag caccugcacc uggagaccuu caaggccgug      300

cuggacggcc uggacgugcu gcuggcccag gaggugagac ccagaagaug gaagcugcag      360

gugcuggacc ugagaaagaa cagccaccag gacuucugga ccguguggag cggcaacaga      420

gccagccugu acagcuuccc cgagcccgag gccgcccagc ccaugaccaa gaagagaaag      480

guggacggcc ugagcaccga ggccgagcag cccuucaucc ccguggaggu gcugguggac      540

cuguuccuga aggagggcgc cugcgacgag cuguucagcu accugaucga gaaggugaag      600

agaaagaaga acgugcugag acugugcugc aagaagcuga agaucuucgc caugcccaug      660

caggacauca agaugauccu gaagauggug cagcuggaca gcaucgagga ccuggaggug      720

accugcaccu ggaagcugcc cacccuggcc aaguucagcc ccuaccuggg ccagaugauc      780

aaccugagaa gacugcugcu gagccacauc cacgccagca gcuacaucag ccccgagaag      840

gaggagcagu acaucgccca guucaccagc caguuccuga gccugcagug ccugcaggcc      900

cuguacgugg acagccuguu cuuccugaga ggcagacugg accagcugcu gagacacgug      960

augaaccccc uggagacccu gagcaucacc aacugcagac ugagcgaggg cgacgugaug     1020

caccugagcc agagccccag cgugagccag cugagcgugc ugagccugag cggcgugaug     1080

cugaccgacg ugagccccga gccccugcag gcccugcugg agagagccag cgccacccug     1140

caggaccugg uguucgacga gugcggcauc accgacgacc agcugcuggc ccugcugccc     1200

agccugagcc acugcagcca gcugaccacc cugagcuucu acggcaacag caucagcauc     1260

agcgcccugc agagccugcu gcagcaccug aucggccuga gcaaccugac ccacgugcug     1320

uaccccgugc cccuggagag cuacgaggac auccacggca cccugcaccu ggagagacug     1380

gccuaccugc acgccagacu gagagagcug cugugcgagc ugggcagacc cagcauggug     1440

uggcugagcg ccaaccccug cccccacugc ggcgacagaa ccuucuacga ccccgagccc     1500

auccugugcc ccugcuucau gcccaacuga                                      1530


<210>  3190
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRAME__Homo_sapiens__AAC51160

<400>  3190
auggagagac ggcgccugug gggcagcauc caguccagau acauuucuau gagcgugugg       60

accucucccc ggcgccucgu cgaacuggcc gggcaauccc uucugaagga cgaggcucuc      120

gccaucgcgg cucuggaacu ucugccuaga gagcuuuucc cgccccuguu uauggccgcc      180

uucgauggac ggcacagcca gacacugaaa gcuaugguuc aggccuggcc uuuuacgugc      240

cucccccugg gcgugcuuau gaaggggcag caucugcacc ucgaaaccuu caaagcugug      300

cuggacggac uugauguccu gcucgcccaa gaggugcgcc cuagacggug gaagcugcag      360

guucuggacc uccgcaaaaa cucccaucag gauuuuugga cagugugguc uggcaauaga      420

gcgagccugu auuccuuccc cgagccugaa gccgcucagc cgaugaccaa gaagcggaaa      480

gucgacgggc uuagcacaga ggccgaacaa cccuuuauuc cuguggaggu ucugguggau      540

cucuuccuga aggagggagc uugugacgaa cucuuuucuu accugaucga gaaagucaag      600

cgcaaaaaga acgugcucag acugugcugu aagaaacuga agauuuucgc caugcccaug      660

caggauauca aaaugauccu caagauggug cagcuggacu ccauugaaga ucuugagguu      720

accugcacau ggaaacugcc uacccucgcg aaguuuagcc ccuaucuggg ccagaugauc      780

aaucuucggc gccugcuccu gucucacauu caugccucca gcuacaucuc uccggaaaaa      840

gaggagcaau auauugcuca guucacgucc caguuucuga gccuccaaug ucugcaggcc      900

cuuuacgucg acucccuguu cuuccucaga ggccggcugg aucagcugcu uagacacgug      960

augaacccuc ucgaaacccu gucuaucaca aauugccgcc ugagcgaggg ggacgugaug     1020

caccucuccc agagccccuc ugucucccaa cugagcgugc uuucucugag cggaguuaug     1080

cucaccgacg uguccccuga accccugcag gcucugcuug agcgggccuc ugccacacuc     1140

caggaucugg ucuuugacga auguggcauu accgaugacc agcugcucgc ucugcuuccc     1200

agccuguccc auugcagcca acucacgaca cugucuuucu augggaacuc caucagcauc     1260

ucugcgcugc agucccuucu ccagcaccug auuggacuga gcaaucucac ccaugugcug     1320

uacccuguuc cgcuugaguc cuacgaggau auccacggca cacugcaccu cgaaagacug     1380

gccuaucugc augcucgccu ucgggagcuc cugugugaac uggggagacc cucuauggug     1440

uggcucagcg ccaacccuug cccccacugu ggagaccgca ccuuuuacga uccugagccc     1500

auucugugcc cgugcuucau gccuaauuga                                      1530


<210>  3191
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRDX5/m__Homo_sapiens__P30044

<400>  3191

Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile 
1               5                   10                  15      


Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg 
            20                  25                  30          


Tyr Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg 
        35                  40                  45              


Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala 
    50                  55                  60                  


Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu 
65                  70                  75                  80  


Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe 
                85                  90                  95      


Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala 
            100                 105                 110         


Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val 
        115                 120                 125             


Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu 
    130                 135                 140                 


Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu 
145                 150                 155                 160 


Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg 
                165                 170                 175     


Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala 
            180                 185                 190         


Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro 
        195                 200                 205             


Asn Ile Ile Ser Gln Leu 
    210                 


<210>  3192
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3192
augggacuag cuggcgugug cgcccugaga cgcucagcgg gcuauauacu cgucgguggg       60

gccggcgguc agucugcggc agcggcagca agacgguaca gugaaggaga gugggcgucu      120

ggcggggucc gcaguuucag cagagccgcu gcagccaugg ccccaaucaa ggugggagau      180

gccaucccag caguggaggu guuugaaggg gagccaggga acaaggugaa ccuggcagag      240

cuguucaagg gcaagaaggg ugugcuguuu ggaguuccug gggccuucac cccuggaugu      300

uccaagacac accugccagg guuuguggag caggcugagg cucugaaggc caagggaguc      360

cagguggugg ccugucugag uguuaaugau gccuuuguga cuggcgagug gggccgagcc      420

cacaaggcgg aaggcaaggu ucggcuccug gcugauccca cuggggccuu ugggaaggag      480

acagacuuau uacuagauga uucgcuggug uccaucuuug ggaaucgacg ucucaagagg      540

uucuccaugg ugguacagga uggcauagug aaggcccuga auguggaacc agauggcaca      600

ggccucaccu gcagccuggc acccaauauc aucucacagc ucuga                      645


<210>  3193
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3193
augggccugg ccggggugug cgcccuccgc cggagcgcgg gcuacauccu ggucgggggc       60

gccgggggcc aguccgccgc cgccgcggcc cgccgguaca gcgagggcga gugggccucc      120

gggggcgugc gcagcuucuc ccgggccgcg gccgccaugg cccccaucaa ggugggggac      180

gccaucccgg cggucgaggu guucgagggc gagcccggga acaaggugaa ccuggccgag      240

cuguucaagg gcaagaaggg cguccuguuc ggggugcccg gcgccuucac ccccgggugc      300

agcaagaccc accucccggg cuucguggag caggccgagg cccucaaggc gaagggcguc      360

cagguggugg ccugccuguc cgucaacgac gccuucguga cgggggagug gggccgcgcc      420

cacaaggccg aggggaaggu gcggcugcuc gcggacccca ccggcgccuu cgggaaggag      480

accgaccugc ugcucgacga cagccugguc uccaucuucg gcaaccgccg gcugaagcgc      540

uucagcaugg uggugcagga cggcaucguc aaggcccuca acguggagcc cgacgggacc      600

ggccugacgu gcucccuggc ccccaacauc aucagccagc ucuga                      645


<210>  3194
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3194
augggccucg ccggcgucug cgcccuccgc cgcuccgccg gcuacauccu cgucggcggc       60

gccggcggcc aguccgccgc cgccgccgcc cgccgcuacu ccgagggcga gugggccucc      120

ggcggcgucc gcuccuucuc ccgcgccgcc gccgccaugg cccccaucaa ggucggcgac      180

gccauccccg ccgucgaggu cuucgagggc gagcccggca acaaggucaa ccucgccgag      240

cucuucaagg gcaagaaggg cguccucuuc ggcguccccg gcgccuucac ccccggcugc      300

uccaagaccc accuccccgg cuucgucgag caggccgagg cccucaaggc caagggcguc      360

caggucgucg ccugccucuc cgucaacgac gccuucguca ccggcgagug gggccgcgcc      420

cacaaggccg agggcaaggu ccgccuccuc gccgacccca ccggcgccuu cggcaaggag      480

accgaccucc uccucgacga cucccucguc uccaucuucg gcaaccgccg ccucaagcgc      540

uucuccaugg ucguccagga cggcaucguc aaggcccuca acgucgagcc cgacggcacc      600

ggccucaccu gcucccucgc ccccaacauc aucucccagc ucuga                      645


<210>  3195
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3195
augggccugg ccggggugug cgcucucaga aggagcgcag gauacauccu ugucgguggc       60

gccgggggac aguccgcggc ugccgcagcc cggcgcuauu cugagggcga augggcuuca      120

ggugggguuc gaaguuucag ccgugcagcc gcugccaugg cgcccauuaa ggugggagac      180

gcaauaccug ccguagaggu guuugaaggc gagccaggca acaaagucaa ucuggcugaa      240

uuguucaagg ggaaaaaggg aguguuauuu gguguuccgg gcgccuucac ccccgggugu      300

uccaaaacac aucugccugg auuuguggag caagcagagg cucuaaaggc caagggcguc      360

caggugguag cgugccucuc uguuaacgau gccuucguga cuggugaaug ggggagagca      420

cacaaagcug agggaaaggu caggcugcuu gccgacccaa cgggcgcuuu uggcaaagaa      480

accgaucugu ugcucgacga uucgcuggug ucaaucuucg ggaaucggcg ccugaagaga      540

uuuagcaugg ugguccagga cggaauuguu aaagcccuca acguggagcc cgaugguaca      600

ggcuuaacuu guagucuggc accuaauauc auuucccagc uuuga                      645


<210>  3196
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3196
augggccugg ccggcgugug cgcccugaga agaagcgccg gcuacauccu ggugggcggc       60

gccggcggcc agagcgccgc cgccgccgcc agaagauaca gcgagggcga gugggccagc      120

ggcggcguga gaagcuucag cagagccgcc gccgccaugg cccccaucaa ggugggcgac      180

gccauccccg ccguggaggu guucgagggc gagcccggca acaaggugaa ccuggccgag      240

cuguucaagg gcaagaaggg cgugcuguuc ggcgugcccg gcgccuucac ccccggcugc      300

agcaagaccc accugcccgg cuucguggag caggccgagg cccugaaggc caagggcgug      360

cagguggugg ccugccugag cgugaacgac gccuucguga ccggcgagug gggcagagcc      420

cacaaggccg agggcaaggu gagacugcug gccgacccca ccggcgccuu cggcaaggag      480

accgaccugc ugcuggacga cagccuggug agcaucuucg gcaacagaag acugaagaga      540

uucagcaugg uggugcagga cggcaucgug aaggcccuga acguggagcc cgacggcacc      600

ggccugaccu gcagccuggc ccccaacauc aucagccagc uguga                      645


<210>  3197
<211>  645
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRDX5/m__Homo_sapiens__CCDS8069.1

<400>  3197
augggccugg ccggggugug cgcucucaga cggagcgccg gauacauccu ggucggcggg       60

gcgggaggcc aguccgcugc cgccgcugcc cgcagauauu cugaggggga augggcuagc      120

ggaggcguuc gguccuucuc ucgcgccgcg gccgcuaugg cccccauuaa ggugggcgac      180

gcuaucccug ccguggaggu cuuugaaggg gagccgggaa acaaagugaa ucuugcggaa      240

cuguucaagg gcaaaaaggg gguucucuuu ggagugcccg gcgccuucac cccugggugu      300

agcaaaacac aucugcccgg auuugucgag caagcugagg cccuuaaggc uaagggcgug      360

cagguugugg ccugccuguc cgucaacgau gccuucguga cgggcgaaug ggggagagcu      420

cacaaagcgg agggaaaggu gcggcuccug gccgacccua ccggcgcuuu ugggaaagaa      480

acagaucugc uccuggacga uucucuuguc agcauuuucg gaaaucgcag acugaagcgg      540

uuuuccaugg uugugcagga cggcaucgug aaagcccuca acgucgagcc cgaugggacc      600

ggacugacau guagccuugc cccuaauauu aucucucagc uguga                      645


<210>  3198
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRM2__Homo_sapiens__P04554

<400>  3198

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Gly Cys Arg Thr Arg Lys 
                85                  90                  95      


Arg Thr Cys Arg Arg His 
            100         


<210>  3199
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRM2__Homo_sapiens__AAA63250

<400>  3199
augguccgau accgcgugag gagccugagc gaacgcucgc acgaggugua caggcagcag       60

uugcaugggc aagagcaagg acaccacggc caagaggagc aagggcugag cccggagcac      120

gucgaggucu acgagaggac ccauggccag ucucacuaua ggcgcagaca cugcucucga      180

aggaggcugc accggaucca caggcggcag caucgcuccu gcagaaggcg caaaagacgc      240

uccugcaggc accggaggag gcaucgcaga ggcugcagaa ccaggaagag aacaugcaga      300

aggcacuaa                                                              309


<210>  3200
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRM2__Homo_sapiens__AAA63250

<400>  3200
auggugcgcu accggguccg cagccugucc gagcggagcc acgaggugua ccgccagcag       60

cuccacggcc aggagcaggg gcaccacggc caggaggagc aggggcuguc ccccgagcac      120

guggaggucu acgagcggac ccacggccag agccacuacc gccggcgcca cugcucccgg      180

cgccggcugc accgcaucca ccggcgccag caccggagcu gccgccggcg caagcggcgc      240

uccugccggc accgccgccg gcaccgccgg gggugccgca cccggaagcg cacgugccgg      300

cgccacuga                                                              309


<210>  3201
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRM2__Homo_sapiens__AAA63250

<400>  3201
augguccgcu accgcguccg cucccucucc gagcgcuccc acgaggucua ccgccagcag       60

cuccacggcc aggagcaggg ccaccacggc caggaggagc agggccucuc ccccgagcac      120

gucgaggucu acgagcgcac ccacggccag ucccacuacc gccgccgcca cugcucccgc      180

cgccgccucc accgcaucca ccgccgccag caccgcuccu gccgccgccg caagcgccgc      240

uccugccgcc accgccgccg ccaccgccgc ggcugccgca cccgcaagcg caccugccgc      300

cgccacuga                                                              309


<210>  3202
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRM2__Homo_sapiens__AAA63250

<400>  3202
auggugagau acaggguccg gagccugucc gagcgcucuc acgaaguuua ucgacagcaa       60

cuccauggcc aggagcaggg gcaccaugga caggaggaac aaggucuuuc acccgaacac      120

guggagguau acgagcguac ccauggccag agucacuaua gaaggcggca cugcagccgc      180

agaaggcugc aucggaucca ccgccgacag cauagauccu guaggcggcg uaagcgcaga      240

ucuugcaggc accggcgacg ccacagaagg gggugucgga cacgcaaaag aacuugcagg      300

cgucauuga                                                              309


<210>  3203
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRM2__Homo_sapiens__AAA63250

<400>  3203
auggugagau acagagugag aagccugagc gagagaagcc acgaggugua cagacagcag       60

cugcacggcc aggagcaggg ccaccacggc caggaggagc agggccugag ccccgagcac      120

guggaggugu acgagagaac ccacggccag agccacuaca gaagaagaca cugcagcaga      180

agaagacugc acagaaucca cagaagacag cacagaagcu gcagaagaag aaagagaaga      240

agcugcagac acagaagaag acacagaaga ggcugcagaa ccagaaagag aaccugcaga      300

agacacuga                                                              309


<210>  3204
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRM2__Homo_sapiens__AAA63250

<400>  3204
auggugagau accggguccg cagccugucc gagagaucuc acgaaguuua ucggcagcaa       60

cuccauggcc aggagcaggg gcaccaugga caggaggaac aaggccugag ccccgaacac      120

guggaggugu acgagcgcac ccaugggcag ucccacuaua gacggcgcca cugcucuaga      180

cggcgccuuc auagaaucca ccggcgccag cauagaagcu gucggcgcag aaagcggaga      240

uccugccgcc accggagacg ccaccggaga ggaugucgca cacggaaaag aacgugccgc      300

cggcauuga                                                              309


<210>  3205
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  prostein__Homo_sapiens__Q96JT2

<400>  3205

Met Val Gln Arg Leu Trp Val Ser Arg Leu Leu Arg His Arg Lys Ala 
1               5                   10                  15      


Gln Leu Leu Leu Val Asn Leu Leu Thr Phe Gly Leu Glu Val Cys Leu 
            20                  25                  30          


Ala Ala Gly Ile Thr Tyr Val Pro Pro Leu Leu Leu Glu Val Gly Val 
        35                  40                  45              


Glu Glu Lys Phe Met Thr Met Val Leu Gly Ile Gly Pro Val Leu Gly 
    50                  55                  60                  


Leu Val Cys Val Pro Leu Leu Gly Ser Ala Ser Asp His Trp Arg Gly 
65                  70                  75                  80  


Arg Tyr Gly Arg Arg Arg Pro Phe Ile Trp Ala Leu Ser Leu Gly Ile 
                85                  90                  95      


Leu Leu Ser Leu Phe Leu Ile Pro Arg Ala Gly Trp Leu Ala Gly Leu 
            100                 105                 110         


Leu Cys Pro Asp Pro Arg Pro Leu Glu Leu Ala Leu Leu Ile Leu Gly 
        115                 120                 125             


Val Gly Leu Leu Asp Phe Cys Gly Gln Val Cys Phe Thr Pro Leu Glu 
    130                 135                 140                 


Ala Leu Leu Ser Asp Leu Phe Arg Asp Pro Asp His Cys Arg Gln Ala 
145                 150                 155                 160 


Tyr Ser Val Tyr Ala Phe Met Ile Ser Leu Gly Gly Cys Leu Gly Tyr 
                165                 170                 175     


Leu Leu Pro Ala Ile Asp Trp Asp Thr Ser Ala Leu Ala Pro Tyr Leu 
            180                 185                 190         


Gly Thr Gln Glu Glu Cys Leu Phe Gly Leu Leu Thr Leu Ile Phe Leu 
        195                 200                 205             


Thr Cys Val Ala Ala Thr Leu Leu Val Ala Glu Glu Ala Ala Leu Gly 
    210                 215                 220                 


Pro Thr Glu Pro Ala Glu Gly Leu Ser Ala Pro Ser Leu Ser Pro His 
225                 230                 235                 240 


Cys Cys Pro Cys Arg Ala Arg Leu Ala Phe Arg Asn Leu Gly Ala Leu 
                245                 250                 255     


Leu Pro Arg Leu His Gln Leu Cys Cys Arg Met Pro Arg Thr Leu Arg 
            260                 265                 270         


Arg Leu Phe Val Ala Glu Leu Cys Ser Trp Met Ala Leu Met Thr Phe 
        275                 280                 285             


Thr Leu Phe Tyr Thr Asp Phe Val Gly Glu Gly Leu Tyr Gln Gly Val 
    290                 295                 300                 


Pro Arg Ala Glu Pro Gly Thr Glu Ala Arg Arg His Tyr Asp Glu Gly 
305                 310                 315                 320 


Val Arg Met Gly Ser Leu Gly Leu Phe Leu Gln Cys Ala Ile Ser Leu 
                325                 330                 335     


Val Phe Ser Leu Val Met Asp Arg Leu Val Gln Arg Phe Gly Thr Arg 
            340                 345                 350         


Ala Val Tyr Leu Ala Ser Val Ala Ala Phe Pro Val Ala Ala Gly Ala 
        355                 360                 365             


Thr Cys Leu Ser His Ser Val Ala Val Val Thr Ala Ser Ala Ala Leu 
    370                 375                 380                 


Thr Gly Phe Thr Phe Ser Ala Leu Gln Ile Leu Pro Tyr Thr Leu Ala 
385                 390                 395                 400 


Ser Leu Tyr His Arg Glu Lys Gln Val Phe Leu Pro Lys Tyr Arg Gly 
                405                 410                 415     


Asp Thr Gly Gly Ala Ser Ser Glu Asp Ser Leu Met Thr Ser Phe Leu 
            420                 425                 430         


Pro Gly Pro Lys Pro Gly Ala Pro Phe Pro Asn Gly His Val Gly Ala 
        435                 440                 445             


Gly Gly Ser Gly Leu Leu Pro Pro Pro Pro Ala Leu Cys Gly Ala Ser 
    450                 455                 460                 


Ala Cys Asp Val Ser Val Arg Val Val Val Gly Glu Pro Thr Glu Ala 
465                 470                 475                 480 


Arg Val Val Pro Gly Arg Gly Ile Cys Leu Asp Leu Ala Ile Leu Asp 
                485                 490                 495     


Ser Ala Phe Leu Leu Ser Gln Val Ala Pro Ser Leu Phe Met Gly Ser 
            500                 505                 510         


Ile Val Gln Leu Ser Gln Ser Val Thr Ala Tyr Met Val Ser Ala Ala 
        515                 520                 525             


Gly Leu Gly Leu Val Ala Ile Tyr Phe Ala Thr Gln Val Val Phe Asp 
    530                 535                 540                 


Lys Ser Asp Leu Ala Lys Tyr Ser Ala 
545                 550             


<210>  3206
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  prostein__Homo_sapiens__AAH50416

<400>  3206
augguccaga ggcugugggu gagccgccug cugcggcacc ggaaagccca gcucuugcug       60

gucaaccugc uaaccuuugg ccuggaggug uguuuggccg caggcaucac cuaugugccg      120

ccucugcugc uggaaguggg gguagaggag aaguucauga ccauggugcu gggcauuggu      180

ccagugcugg gccuggucug ugucccgcuc cuaggcucag ccagugacca cuggcgugga      240

cgcuauggcc gccgccggcc cuucaucugg gcacuguccu ugggcauccu gcugagccuc      300

uuucucaucc caagggccgg cuggcuagca gggcugcugu gcccggaucc caggccccug      360

gagcuggcac ugcucauccu gggcgugggg cugcuggacu ucuguggcca ggugugcuuc      420

acuccacugg aggcccugcu cucugaccuc uuccgggacc cggaccacug ucgccaggcc      480

uacucugucu augccuucau gaucagucuu gggggcugcc ugggcuaccu ccugccugcc      540

auugacuggg acaccagugc ccuggccccc uaccugggca cccaggagga gugccucuuu      600

ggccugcuca cccucaucuu ccucaccugc guagcagcca cacugcuggu ggcugaggag      660

gcagcgcugg gccccaccga gccagcagaa gggcugucgg cccccuccuu gucgccccac      720

ugcuguccau gccgggcccg cuuggcuuuc cggaaccugg gcgcccugcu uccccggcug      780

caccagcugu gcugccgcau gccccgcacc cugcgccggc ucuucguggc ugagcugugc      840

agcuggaugg cacucaugac cuucacgcug uuuuacacgg auuucguggg cgaggggcug      900

uaccagggcg ugcccagagc ugagccgggc accgaggccc ggagacacua ugaugaaggc      960

guucggaugg gcagccuggg gcuguuccug cagugcgcca ucucccuggu cuucucucug     1020

gucauggacc ggcuggugca gcgauucggc acucgagcag ucuauuuggc caguguggca     1080

gcuuucccug uggcugccgg ugccacaugc cugucccaca guguggccgu ggugacagcu     1140

ucagccgccc ucaccggguu caccuucuca gcccugcaga uccugcccua cacacuggcc     1200

ucccucuacc accgggagaa gcagguguuc cugcccaaau accgagggga cacuggaggu     1260

gcuagcagug aggacagccu gaugaccagc uuccugccag gcccuaagcc uggagcuccc     1320

uucccuaaug gacacguggg ugcuggaggc aguggccugc ucccaccucc acccgcgcuc     1380

ugcggggccu cugccuguga ugucuccgua cguguggugg ugggugagcc caccgaggcc     1440

agggugguuc cgggccgggg caucugccug gaccucgcca uccuggauag ugccuuccug     1500

cugucccagg uggccccauc ccuguuuaug ggcuccauug uccagcucag ccagucuguc     1560

acugccuaua uggugucugc cgcaggccug ggucuggucg ccauuuacuu ugcuacacag     1620

guaguauuug acaagagcga cuuggccaaa uacucagcgu ag                        1662


<210>  3207
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       prostein__Homo_sapiens__AAH50416

<400>  3207
auggugcagc gccugugggu cagccggcuc cugcgccacc ggaaggccca gcugcuccug       60

gugaaccugc ucaccuucgg ccuggaggug ugccuggccg cggggaucac cuacgugccc      120

ccgcuccugc uggagguggg cguggaggag aaguucauga cgaugguccu cgggaucggc      180

cccgugcugg ggcuggugug cgucccccuc cugggcuccg ccagcgacca cuggcgcggc      240

cgguacgggc gccggcgccc cuucaucugg gcccuguccc ucggcauccu gcugagccuc      300

uuccugaucc cgcgggccgg guggcuggcc ggccuccugu gccccgaccc ccgcccccug      360

gagcucgcgc ugcugauccu cggggugggc cugcuggacu ucugcggcca ggugugcuuc      420

accccgcucg aggcccugcu guccgaccuc uuccgggacc ccgaccacug ccgccaggcc      480

uacagcgucu acgccuucau gaucucccuc gggggcugcc ugggguaccu gcugcccgcg      540

aucgacuggg acaccagcgc ccuggccccc uaccucggca cccaggagga gugccuguuc      600

ggccugcuca cgcugaucuu ccugaccugc guggccgcca cccuccuggu ggcggaggag      660

gccgcccugg ggcccaccga gcccgccgag ggccuguccg cccccagccu cagcccccac      720

ugcugcccgu gccgggcgcg ccuggccuuc cggaaccugg gggcccuccu gccccgccug      780

caccagcucu gcugccggau gccccgcacg cugcggcgcc uguucgucgc cgagcucugc      840

uccuggaugg cccugaugac cuucacccug uucuacaccg acuucguggg cgaggggcuc      900

uaccagggcg ugccccgggc ggagccgggc acggaggccc gccgccacua cgacgagggg      960

guccggaugg gcucccuggg gcuguuccuc cagugcgcca ucagccuggu guucucccug     1020

gugauggacc gccucgucca gcgguucggc acccgcgccg uguaccuggc cagcguggcg     1080

gccuuccccg ucgccgccgg ggcgaccugc cugucccaca gcguggccgu cgugaccgcc     1140

uccgccgccc ucacgggcuu caccuucagc gcgcugcaga uccugcccua cacccucgcc     1200

agccuguacc accgggagaa gcaggucuuc cugcccaagu accgcggcga caccgggggc     1260

gccuccagcg aggacucccu caugacgagc uuccugccgg ggcccaagcc cggcgccccc     1320

uucccgaacg ggcacgucgg cgccggcggg uccggccugc ucccgccgcc gcccgcgcug     1380

ugcggggcca gcgccugcga cguguccgug cgggucgugg ugggcgagcc caccgaggcc     1440

cgcgucgugc ccggccgggg gaucugccug gaccucgcca uccuggacag cgcguuccug     1500

cucucccagg uggcccccag ccuguucaug ggcuccaucg uccagcugag ccaguccgug     1560

accgccuaca uggugagcgc cgcggggcuc ggccuggucg ccaucuacuu cgccacccag     1620

gugguguucg acaaguccga ccuggccaag uacagcgccu ga                        1662


<210>  3208
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       prostein__Homo_sapiens__AAH50416

<400>  3208
augguccagc gccucugggu cucccgccuc cuccgccacc gcaaggccca gcuccuccuc       60

gucaaccucc ucaccuucgg ccucgagguc ugccucgccg ccggcaucac cuacgucccc      120

ccccuccucc ucgaggucgg cgucgaggag aaguucauga ccaugguccu cggcaucggc      180

cccguccucg gccucgucug cgucccccuc cucggcuccg ccuccgacca cuggcgcggc      240

cgcuacggcc gccgccgccc cuucaucugg gcccucuccc ucggcauccu ccucucccuc      300

uuccucaucc cccgcgccgg cuggcucgcc ggccuccucu gccccgaccc ccgcccccuc      360

gagcucgccc uccucauccu cggcgucggc cuccucgacu ucugcggcca ggucugcuuc      420

accccccucg aggcccuccu cuccgaccuc uuccgcgacc ccgaccacug ccgccaggcc      480

uacuccgucu acgccuucau gaucucccuc ggcggcugcc ucggcuaccu ccuccccgcc      540

aucgacuggg acaccuccgc ccucgccccc uaccucggca cccaggagga gugccucuuc      600

ggccuccuca cccucaucuu ccucaccugc gucgccgcca cccuccucgu cgccgaggag      660

gccgcccucg gccccaccga gcccgccgag ggccucuccg cccccucccu cuccccccac      720

ugcugccccu gccgcgcccg ccucgccuuc cgcaaccucg gcgcccuccu cccccgccuc      780

caccagcucu gcugccgcau gccccgcacc cuccgccgcc ucuucgucgc cgagcucugc      840

uccuggaugg cccucaugac cuucacccuc uucuacaccg acuucgucgg cgagggccuc      900

uaccagggcg ucccccgcgc cgagcccggc accgaggccc gccgccacua cgacgagggc      960

guccgcaugg gcucccucgg ccucuuccuc cagugcgcca ucucccucgu cuucucccuc     1020

gucauggacc gccucgucca gcgcuucggc acccgcgccg ucuaccucgc cuccgucgcc     1080

gccuuccccg ucgccgccgg cgccaccugc cucucccacu ccgucgccgu cgucaccgcc     1140

uccgccgccc ucaccggcuu caccuucucc gcccuccaga uccuccccua cacccucgcc     1200

ucccucuacc accgcgagaa gcaggucuuc cuccccaagu accgcggcga caccggcggc     1260

gccuccuccg aggacucccu caugaccucc uuccuccccg gccccaagcc cggcgccccc     1320

uuccccaacg gccacgucgg cgccggcggc uccggccucc uccccccccc ccccgcccuc     1380

ugcggcgccu ccgccugcga cgucuccguc cgcgucgucg ucggcgagcc caccgaggcc     1440

cgcgucgucc ccggccgcgg caucugccuc gaccucgcca uccucgacuc cgccuuccuc     1500

cucucccagg ucgcccccuc ccucuucaug ggcuccaucg uccagcucuc ccaguccguc     1560

accgccuaca uggucuccgc cgccggccuc ggccucgucg ccaucuacuu cgccacccag     1620

gucgucuucg acaaguccga ccucgccaag uacuccgccu ga                        1662


<210>  3209
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       prostein__Homo_sapiens__AAH50416

<400>  3209
auggugcaga gacugugggu cagcaggcuc cuucggcacc gcaaggccca acuguuguua       60

guuaaccugc uaaccuucgg ccucgaggug ugccuggcug cagggaucac auacguaccc      120

ccucuucugu uggaaguggg agucgaggaa aaauuuauga cuauggugcu cgguauuggc      180

ccaguucugg ggcuggugug ugucccgcuc uuaggauccg ccucugacca uuggcgaggc      240

cguuauggua gaaggcggcc cuucauaugg gcgcugucac uugggaucuu gcugagucua      300

uuucucauuc cucgcgcugg auggcuggcc ggccuucugu gcccagaucc cagaccuuug      360

gagcucgcac uguuaauccu gggcgugggg cuccuugacu ucuguggaca gguaugcuuu      420

acgccacugg aagccuugcu aagcgaucug uucagggacc ccgaucacug ucggcaggcu      480

uacuccguuu augcauuuau gauuucucuc gguggcugcc ugggguaccu ucugccugcc      540

aucgacuggg auaccucggc uuuggcccca uaucucggaa cacaggagga gugucuguuc      600

ggcuuacuga cucuaauauu uuugaccugc guggcggcaa cacugcuugu cgccgaagag      660

gcugccuugg guccgaccga acccgcagag gggcugucag cuccuagccu caguccacau      720

uguugccccu gucgcgcccg acuggcguuc agaaaucuug gagcccuguu gccuaggcuc      780

caccaacugu gcugccggau gccacguacu uuacgcagac uguuuguggc agagcuaugu      840

uccuggaugg cucucaugac auucacccug uuuuacacgg acuucguggg cgaaggccuu      900

uaucaggggg uccccagggc cgagccggga acugaagcuc ggcgacauua cgaugagggu      960

guucgcaugg gcucuuuggg gcuguuccuc cagugcgcca ucagccuggu guuuuccuua     1020

guaauggaca gacuggugca gagguucgga acccgggcag ucuaccuugc cucaguggcu     1080

gcguuuccug uugcagccgg cgcuacaugu uugagucaca gcguggccgu cgugacugca     1140

ucugccgcuc ucaccgguuu cacauuuucc gcccugcaaa uucuacccua uacccuggca     1200

ucacucuacc accgcgaaaa gcagguauuc cugccaaaau auagagggga uacgggcgga     1260

gcgagcagug aggacucucu uaugacuucc uuuuugccug gccccaagcc aggggcuccc     1320

uucccuaacg gacauguugg ugccggcggg agcggacugu uaccaccgcc cccugcacuc     1380

ugcggcgccu cggcuuguga ugugucuguc aggguggucg ugggugagcc aacagaagcc     1440

cguguugugc ccgggcgggg caucugccug gaccuugcaa uucuggacuc cgcuuuucuc     1500

cucucacagg uagccccuag ucuguucaug ggaagcaucg uccagcuauc ccaaucugug     1560

accgcguaca ugguuagcgc cgcuggccug gggcucgugg caauauauuu ugccacucag     1620

gucguguucg auaaaucaga ccuggcuaag uacagugccu ga                        1662


<210>  3210
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       prostein__Homo_sapiens__AAH50416

<400>  3210
auggugcaga gacugugggu gagcagacug cugagacaca gaaaggccca gcugcugcug       60

gugaaccugc ugaccuucgg ccuggaggug ugccuggccg ccggcaucac cuacgugccc      120

ccccugcugc uggagguggg cguggaggag aaguucauga ccauggugcu gggcaucggc      180

cccgugcugg gccuggugug cgugccccug cugggcagcg ccagcgacca cuggagaggc      240

agauacggca gaagaagacc cuucaucugg gcccugagcc ugggcauccu gcugagccug      300

uuccugaucc ccagagccgg cuggcuggcc ggccugcugu gccccgaccc cagaccccug      360

gagcuggccc ugcugauccu gggcgugggc cugcuggacu ucugcggcca ggugugcuuc      420

accccccugg aggcccugcu gagcgaccug uucagagacc ccgaccacug cagacaggcc      480

uacagcgugu acgccuucau gaucagccug ggcggcugcc ugggcuaccu gcugcccgcc      540

aucgacuggg acaccagcgc ccuggccccc uaccugggca cccaggagga gugccuguuc      600

ggccugcuga cccugaucuu ccugaccugc guggccgcca cccugcuggu ggccgaggag      660

gccgcccugg gccccaccga gcccgccgag ggccugagcg cccccagccu gagcccccac      720

ugcugccccu gcagagccag acuggccuuc agaaaccugg gcgcccugcu gcccagacug      780

caccagcugu gcugcagaau gcccagaacc cugagaagac uguucguggc cgagcugugc      840

agcuggaugg cccugaugac cuucacccug uucuacaccg acuucguggg cgagggccug      900

uaccagggcg ugcccagagc cgagcccggc accgaggcca gaagacacua cgacgagggc      960

gugagaaugg gcagccuggg ccuguuccug cagugcgcca ucagccuggu guucagccug     1020

gugauggaca gacuggugca gagauucggc accagagccg uguaccuggc cagcguggcc     1080

gccuuccccg uggccgccgg cgccaccugc cugagccaca gcguggccgu ggugaccgcc     1140

agcgccgccc ugaccggcuu caccuucagc gcccugcaga uccugcccua cacccuggcc     1200

agccuguacc acagagagaa gcagguguuc cugcccaagu acagaggcga caccggcggc     1260

gccagcagcg aggacagccu gaugaccagc uuccugcccg gccccaagcc cggcgccccc     1320

uuccccaacg gccacguggg cgccggcggc agcggccugc ugcccccccc ccccgcccug     1380

ugcggcgcca gcgccugcga cgugagcgug agaguggugg ugggcgagcc caccgaggcc     1440

agaguggugc ccggcagagg caucugccug gaccuggcca uccuggacag cgccuuccug     1500

cugagccagg uggcccccag ccuguucaug ggcagcaucg ugcagcugag ccagagcgug     1560

accgccuaca uggugagcgc cgccggccug ggccuggugg ccaucuacuu cgccacccag     1620

gugguguucg acaagagcga ccuggccaag uacagcgccu ga                        1662


<210>  3211
<211>  1662
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       prostein__Homo_sapiens__AAH50416

<400>  3211
auggugcaga gacugugggu cagccggcuc cugcgccaca gaaaggccca acuucugcuc       60

guuaaccugc uuaccuucgg ccuggaggug ugccucgcug ccgggaucac auacgugccc      120

ccucugcugc ucgaagucgg aguggaggaa aaauuuauga cgaugguucu gggcauuggg      180

ccggugcuug gacuggucug ugugccccuc cugggcuccg cgucugacca uuggcggggg      240

cgcuauggaa gacggcgccc uuucaucugg gcucuuagcc ugggcauucu ccugucccug      300

uuucucaucc ccagagccgg cuggcuggcc gggcuucugu gcccugaucc ccggccucuc      360

gagcuggccc uucugauucu cggaguuggc cugcuggacu ucuguggaca ggugugcuuu      420

accccgcucg aagcucugcu uucugaucug uuccgcgacc ccgaucacug uagacaggcu      480

uacagcgucu augccuuuau gaucucccuc gggggcugcc ugggguaccu ucugccugcg      540

aucgacuggg auacaucugc ccucgcuccc uaucugggaa cccaggagga gugucuguuc      600

ggccuccuga cacuuauuuu ucugaccugc guggccgcua cacuccuggu ggccgaagag      660

gcggcccugg gcccuaccga acccgcugag gggcuuagcg ccccgucccu cagcccucau      720

uguugccccu gucgggcucg ccuggccuuc agaaaucugg gagcccuccu gccucggcuu      780

caccaacugu gcugccgcau gcccagaacg cuccggagac uguuugucgc ugagcugugu      840

ucuuggaugg cgcuuaugac cuucacacuc uuuuacaccg acuucguugg cgaagggcug      900

uaucagggag ugccccgcgc cgagccuggc acagaagcuc ggagacauua cgaugagggg      960

gugcgcaugg gaucccuggg ccucuuccug cagugcgcca ucagccuugu cuuuucucug     1020

gugauggacc ggcucguuca gagauucggc acccgcgccg uguaccuggc uuccgucgcc     1080

gcguuuccgg uggcugccgg ggccacgugu cugagccacu cuguugcugu ggucacagcc     1140

uccgcugccc uuaccggauu cacauuuagc gcgcuccaaa uucugcccua uacccuggcc     1200

ucccucuacc accgggaaaa acagguguuc cugccuaagu auagaggcga uaccggggga     1260

gcuucuagcg aggacucccu uaugacgagc uuucugcccg gcccuaagcc cggggccccg     1320

uucccuaacg gccaugucgg agcuggcggg ucuggacucc ugcccccucc cccugcccug     1380

ugcggcgcgu ccgccuguga ugugagcguu cgcguggucg ugggggagcc cacagaagcu     1440

cggguugugc cgggaagagg caucugccuu gaccucgcca uucuggacuc ugcuuuucug     1500

cucagccagg ucgccccuuc ccuguucaug gggucuaucg ugcagcuuag ccaauccgug     1560

accgccuaca ugguuagcgc ugcgggccug ggacucgucg ccauuuauuu ugcuacacag     1620

gugguguucg auaaaucuga ccuggccaag uacuccgccu ga                        1662


<210>  3212
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  proteinase-3__Homo_sapiens__D6CHE9

<400>  3212

Met Ala Ser Leu Gln Met Arg Gly Asn Pro Gly Ser His Phe Cys Gly 
1               5                   10                  15      


Gly Thr Leu Ile His Pro Ser Phe Val Leu Thr Ala Ala His Cys Leu 
            20                  25                  30          


Arg Asp Ile Pro Gln Arg Leu Val Asn Val Val Leu Gly Ala His Asn 
        35                  40                  45              


Val Arg Thr Gln Glu Pro Thr Gln Gln His Phe Ser Val Ala Gln Val 
    50                  55                  60                  


Phe Leu Asn Asn Tyr Asp Ala Glu Asn Lys Leu Asn Asp Ile Leu Leu 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Pro Ala Asn Leu Ser Ala Ser Val Ala Thr Val 
                85                  90                  95      


Gln Leu Pro Gln Gln Asp Gln Pro Val Pro His Gly Thr Gln Cys Leu 
            100                 105                 110         


Ala Met Gly Trp Gly Arg Val Gly Ala His Asp Pro Pro Ala Gln Val 
        115                 120                 125             


Leu Gln Glu Leu Asn Val Thr Val Val Thr Phe Phe Cys Arg Pro His 
    130                 135                 140                 


Asn Ile Cys Thr Phe Val Pro Arg Arg Lys Ala Gly Ile Cys Phe Gly 
145                 150                 155                 160 


Asp Ser Gly Gly Pro Leu Ile Cys Asp Gly Ile Ile Gln Gly Ile Asp 
                165                 170                 175     


Ser Phe Val Ile Trp Gly Cys Ala Thr Arg Leu Phe Pro Asp Phe Phe 
            180                 185                 190         


Thr Arg Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg Arg 
        195                 200                 205             


Val Glu Ala Lys Gly Arg Pro 
    210                 215 


<210>  3213
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  proteinase-3__Homo_sapiens__CBI83574

<400>  3213
auggccuccc ugcagaugcg ggggaacccg ggcagccacu ucugcggagg caccuugauc       60

caccccagcu ucgugcugac ggccgcgcac ugccugcggg acauacccca gcgccuggug      120

aacguggugc ucggagccca caacgugcgg acgcaggagc ccacccagca gcacuucucg      180

guggcucagg uguuucugaa caacuacgac gcggagaaca aacugaacga cauucuccuc      240

auccagcuga gcagcccagc caaccucagu gccuccgucg ccacagucca gcugccacag      300

caggaccagc cagugcccca cggcacccag ugccuggcca ugggcugggg ccgcgugggu      360

gcccacgacc ccccagccca gguccugcag gagcucaaug ucaccguggu gaccuucuuc      420

ugccggccac auaacauuug cacuuucguc ccucgccgca aggccggcau cugcuucgga      480

gacucaggug gcccccugau cugugauggc aucauccaag gaauagacuc cuucgugauc      540

uggggaugug ccacccgccu uuucccugac uucuucacgc ggguagcccu cuacguggac      600

uggauccguu ccacgcugcg ccguguggag gccaagggcc gccccuga                   648


<210>  3214
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       proteinase-3__Homo_sapiens__CBI83574

<400>  3214
auggccagcc ugcagaugcg cggcaacccc gggucccacu ucugcggcgg gacccucauc       60

cacccgagcu ucgugcugac cgccgcgcac ugccugcggg acauccccca gcgccucguc      120

aacguggugc ugggcgccca caacguccgg acgcaggagc ccacccagca gcacuucucc      180

guggcccagg uguuccugaa caacuacgac gccgagaaca agcucaacga cauccugcug      240

auccagcuca gcucccccgc caaccugagc gcguccgucg ccaccgugca gcugccgcag      300

caggaccagc ccgugcccca cgggacccag ugccucgcca ugggcugggg ccgcgucggg      360

gcccacgacc cgcccgccca ggugcugcag gagcugaacg ugacggucgu gaccuucuuc      420

ugccggcccc acaacaucug caccuucgug ccccgccgga aggcgggcau cugcuucggg      480

gacagcggcg ggccccucau cugcgacggc aucauccagg gcaucgacuc cuucgucauc      540

ugggggugcg ccacccgccu guucccggac uucuucacgc ggguggcccu guacguggac      600

uggauccgca gcacccuccg gcgcgucgag gccaagggcc ggcccuga                   648


<210>  3215
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       proteinase-3__Homo_sapiens__CBI83574

<400>  3215
auggccuccc uccagaugcg cggcaacccc ggcucccacu ucugcggcgg cacccucauc       60

caccccuccu ucguccucac cgccgcccac ugccuccgcg acauccccca gcgccucguc      120

aacgucgucc ucggcgccca caacguccgc acccaggagc ccacccagca gcacuucucc      180

gucgcccagg ucuuccucaa caacuacgac gccgagaaca agcucaacga cauccuccuc      240

auccagcucu ccucccccgc caaccucucc gccuccgucg ccaccgucca gcucccccag      300

caggaccagc ccguccccca cggcacccag ugccucgcca ugggcugggg ccgcgucggc      360

gcccacgacc cccccgccca gguccuccag gagcucaacg ucaccgucgu caccuucuuc      420

ugccgccccc acaacaucug caccuucguc ccccgccgca aggccggcau cugcuucggc      480

gacuccggcg gcccccucau cugcgacggc aucauccagg gcaucgacuc cuucgucauc      540

uggggcugcg ccacccgccu cuuccccgac uucuucaccc gcgucgcccu cuacgucgac      600

uggauccgcu ccacccuccg ccgcgucgag gccaagggcc gccccuga                   648


<210>  3216
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       proteinase-3__Homo_sapiens__CBI83574

<400>  3216
auggccagcc ugcagaugag aggcaacccc gggucccacu ucugcggagg uacccucauc       60

cauccuucuu uugugcuuac agcugcacac ugucugaggg acauuccaca acgguugguc      120

aauguugugu uaggcgccca uaacguacgc acucaggagc cgacgcagca gcacuucuca      180

guggcgcaag ucuuucugaa uaacuacgau gcugaaaaua agcuaaacga cauacuccug      240

auccagcuua guagccccgc caaucugucc gcaucugugg ccaccguuca guugccucag      300

caagaucagc cagugcccca ugggacacag ugccucgcua ugggaugggg ccgagucggu      360

gcacacgacc cuccagccca ggugcugcaa gagcugaacg uaacuguugu gaccuucuuu      420

ugucgucccc acaauauuug cacauucguc ccuagaagga aagcugggau cuguuuugga      480

gauucgggcg gcccacucau uugcgacggg aucauacagg gaaucgauuc auucgugauu      540

ugggguugug ccacccgguu auuuccggac uucuuuacuc gcguggcgcu guaugucgau      600

uggaucagaa gcacacuuag gcggguugaa gcaaagggcc gccccuga                   648


<210>  3217
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       proteinase-3__Homo_sapiens__CBI83574

<400>  3217
auggccagcc ugcagaugag aggcaacccc ggcagccacu ucugcggcgg cacccugauc       60

caccccagcu ucgugcugac cgccgcccac ugccugagag acauccccca gagacuggug      120

aacguggugc ugggcgccca caacgugaga acccaggagc ccacccagca gcacuucagc      180

guggcccagg uguuccugaa caacuacgac gccgagaaca agcugaacga cauccugcug      240

auccagcuga gcagccccgc caaccugagc gccagcgugg ccaccgugca gcugccccag      300

caggaccagc ccgugcccca cggcacccag ugccuggcca ugggcugggg cagagugggc      360

gcccacgacc cccccgccca ggugcugcag gagcugaacg ugaccguggu gaccuucuuc      420

ugcagacccc acaacaucug caccuucgug cccagaagaa aggccggcau cugcuucggc      480

gacagcggcg gcccccugau cugcgacggc aucauccagg gcaucgacag cuucgugauc      540

uggggcugcg ccaccagacu guuccccgac uucuucacca gaguggcccu guacguggac      600

uggaucagaa gcacccugag aagaguggag gccaagggca gacccuga                   648


<210>  3218
<211>  648
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       proteinase-3__Homo_sapiens__CBI83574

<400>  3218
auggccagcc ugcagaugag aggcaacccc gggucccacu ucugcggagg cacccucauc       60

cauccuucuu uugugcugac agcugcccac ugucuucggg acauuccgca acgccugguc      120

aauguugugc ucggggcgca uaacgugaga acgcaggagc ccacccagca gcacuucagc      180

gucgcucaag uguuucugaa uaacuacgau gccgaaaaua aacuuaacga cauccugcuc      240

auucagcugu ccucuccugc caaucugagc gcuuccguug ccacagugca gcucccccag      300

caagaucagc cuguccccca uggaacccag ugccuggcua ugggcugggg gcggguggga      360

gcccacgacc cuccggcgca gguucuucaa gagcugaacg ugacagucgu gaccuucuuu      420

ugucgccccc acaauaucug cacauucgug ccuagacgga aggccggcau uuguuuuggc      480

gauucugggg gaccccucau cugcgacggc aucauucagg ggaucgauag cuucgucauu      540

uggggaugug cuacccgccu guuuccugac uucuuuacga gaguugcccu uuauguggau      600

uggauccggu ccacccugcg cagaguggaa gcuaagggcc ggcccuga                   648


<210>  3219
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  proteinase-3__Homo_sapiens__P24158

<400>  3219

Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 
            20                  25                  30          


Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 
        35                  40                  45              


Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 
    50                  55                  60                  


Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 
65                  70                  75                  80  


Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 
                85                  90                  95      


Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 
            100                 105                 110         


Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 
        115                 120                 125             


Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 
    130                 135                 140                 


Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 
145                 150                 155                 160 


Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 
                165                 170                 175     


Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 
            180                 185                 190         


Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 
        195                 200                 205             


Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 
    210                 215                 220                 


Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 
                245                 250                 255     






<210>  3220
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  proteinase-3__Homo_sapiens__AAH96183

<400>  3220
auggcucacc ggccccccag cccugcccug gcguccgugc ugcuggccuu gcugcugagc       60

ggugcugccc gagcugcgga gaucgugggc gggcacgagg cgcagccaca cucccggccc      120

uacauggccu cccugcagau gcgggggaac ccgggcagcc acuucugcgg aggcaccuug      180

auccacccca gcuucgugcu gacggccgcg cacugccugc gggacauacc ccagcgccug      240

gugaacgugg ugcucggagc ccacaacgug cggacgcagg agcccaccca gcagcacuuc      300

ucgguggcuc agguguuucu gaacaacuac gacgcggaga acaaacugaa cgacguucuc      360

cucauccagc ugagcagccc agccaaccuc agugccuccg ucgccacagu ccagcugcca      420

cagcaggacc agccagugcc ccacggcacc cagugccugg ccaugggcug gggccgcgug      480

ggugcccacg accccccagc ccagguccug caggagcuca augucaccgu ggucaccuuc      540

uucugccggc cacauaacau uugcacuuuc gucccucgcc gcaaggccgg caucugcuuc      600

ggagacucag guggcccccu gaucugugau ggcaucaucc aaggaauaga cuccuucgug      660

aucuggggau gugccacccg ccuuuucccu gacuucuuca cgcggguagc ccucuacgug      720

gacuggaucc guuccacgcu gcgccgugug gaggccaagg gccgccccug a               771


<210>  3221
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       proteinase-3__Homo_sapiens__AAH96183

<400>  3221
auggcccacc ggcccccgag ccccgcccug gcguccgugc uccuggcccu gcuccugagc       60

ggcgccgccc gcgccgcgga gaucgucggg ggccacgagg cccagcccca cucccgcccc      120

uacauggcca gccugcagau gcgggggaac ccgggcuccc acuucugcgg gggcacccuc      180

auccacccca gcuucgugcu gaccgccgcg cacugccugc gcgacauccc ccagcggcuc      240

gugaacgucg ugcugggcgc ccacaacgug cgcacgcagg agcccaccca gcagcacuuc      300

uccgucgccc agguguuccu gaacaacuac gacgccgaga acaagcucaa cgacgugcug      360

cugauccagc ucagcucccc ggccaaccug agcgcguccg ucgccaccgu gcagcugccc      420

cagcaggacc agcccgugcc ccacgggacc cagugccucg ccaugggcug ggggcggguc      480

ggcgcccacg acccgcccgc ccaggugcug caggagcuga acgugacggu cgugaccuuc      540

uucugccgcc cccacaacau cugcaccuuc gugccccggc gcaaggcggg gaucugcuuc      600

ggcgacagcg gcgggccgcu caucugcgac ggcaucaucc aggggaucga cuccuucguc      660

aucuggggcu gcgccacccg gcuguucccc gacuucuuca cgcgcguggc ccuguacgug      720

gacuggaucc ggagcacccu ccgccggguc gaggccaagg gccgccccug a               771


<210>  3222
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       proteinase-3__Homo_sapiens__AAH96183

<400>  3222
auggcccacc gcccccccuc ccccgcccuc gccuccgucc uccucgcccu ccuccucucc       60

ggcgccgccc gcgccgccga gaucgucggc ggccacgagg cccagcccca cucccgcccc      120

uacauggccu cccuccagau gcgcggcaac cccggcuccc acuucugcgg cggcacccuc      180

auccaccccu ccuucguccu caccgccgcc cacugccucc gcgacauccc ccagcgccuc      240

gucaacgucg uccucggcgc ccacaacguc cgcacccagg agcccaccca gcagcacuuc      300

uccgucgccc aggucuuccu caacaacuac gacgccgaga acaagcucaa cgacguccuc      360

cucauccagc ucuccucccc cgccaaccuc uccgccuccg ucgccaccgu ccagcucccc      420

cagcaggacc agcccguccc ccacggcacc cagugccucg ccaugggcug gggccgcguc      480

ggcgcccacg acccccccgc ccagguccuc caggagcuca acgucaccgu cgucaccuuc      540

uucugccgcc cccacaacau cugcaccuuc gucccccgcc gcaaggccgg caucugcuuc      600

ggcgacuccg gcggcccccu caucugcgac ggcaucaucc agggcaucga cuccuucguc      660

aucuggggcu gcgccacccg ccucuucccc gacuucuuca cccgcgucgc ccucuacguc      720

gacuggaucc gcuccacccu ccgccgcguc gaggccaagg gccgccccug a               771


<210>  3223
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       proteinase-3__Homo_sapiens__AAH96183

<400>  3223
auggcccaca gacccccuag cccagcucug gcauccgugc uccuugcccu guuguuaucu       60

ggcgcggcua gggccgcaga gaucgucggg ggacaugaag cccagccgca cucacggccc      120

uacauggcua gucugcaaau gcgcgguaac ccuggcagcc auuucugcgg gggaacccua      180

auucacccau ccuuuguucu cacagcagcc cauugucugc gagacauacc ccagcgucuu      240

gugaauguag ugcugggcgc ucacaacguc agaacucagg agccuacgca gcaacacuuc      300

ucuguggccc agguguuuuu gaauaacuau gaugcggaaa auaagcucaa cgacguucug      360

cugauccagc ucucgucacc agcaaauuua agcgccagug ucgcuaccgu gcagcugccc      420

caacaggauc agccuguacc acaugguaca cagugccuug ccauggggug gggaaggguu      480

ggcgcacacg acccgcccgc ucaaguguug caggagcuga acgucacugu ggugaccuuc      540

uuuugucggc cucauaauau uugcacauuc gucccacgca gaaaagccgg caucuguuuu      600

ggggauuccg gagguccccu aauuugcgac ggcaucauac aggggaucga uucuuucguu      660

auuuggggau gugcgaccag gcucuuuccu gacuucuuua cucggguggc ccuguacgua      720

gauuggaucc gcagcacacu ucgaagagug gaagcaaagg gcaggccaug a               771


<210>  3224
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       proteinase-3__Homo_sapiens__AAH96183

<400>  3224
auggcccaca gaccccccag ccccgcccug gccagcgugc ugcuggcccu gcugcugagc       60

ggcgccgcca gagccgccga gaucgugggc ggccacgagg cccagcccca cagcagaccc      120

uacauggcca gccugcagau gagaggcaac cccggcagcc acuucugcgg cggcacccug      180

auccacccca gcuucgugcu gaccgccgcc cacugccuga gagacauccc ccagagacug      240

gugaacgugg ugcugggcgc ccacaacgug agaacccagg agcccaccca gcagcacuuc      300

agcguggccc agguguuccu gaacaacuac gacgccgaga acaagcugaa cgacgugcug      360

cugauccagc ugagcagccc cgccaaccug agcgccagcg uggccaccgu gcagcugccc      420

cagcaggacc agcccgugcc ccacggcacc cagugccugg ccaugggcug gggcagagug      480

ggcgcccacg acccccccgc ccaggugcug caggagcuga acgugaccgu ggugaccuuc      540

uucugcagac cccacaacau cugcaccuuc gugcccagaa gaaaggccgg caucugcuuc      600

ggcgacagcg gcggcccccu gaucugcgac ggcaucaucc agggcaucga cagcuucgug      660

aucuggggcu gcgccaccag acuguucccc gacuucuuca ccagaguggc ccuguacgug      720

gacuggauca gaagcacccu gagaagagug gaggccaagg gcagacccug a               771


<210>  3225
<211>  771
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       proteinase-3__Homo_sapiens__AAH96183

<400>  3225
auggcccaca gacccccuag cccggcucug gccuccgugc uccuggcgcu ucugcucucu       60

ggcgcugccc gggccgcuga gaucgucggg ggacaugaag cccagcccca cagccgcccu      120

uacauggcuu cccugcaaau gagaggcaac cccgggucuc auuucugcgg aggcacccuu      180

auucacccua gcuuuguucu gacagccgcg cauugucucc gggacauccc ccagcgccug      240

gugaaugugg uccugggggc ccacaacgug agaacgcagg agccuaccca gcaacacuuc      300

uccguugcuc agguguuucu caauaacuau gaugccgaaa auaagcugaa cgacguccuu      360

cugauucagc ucucuagccc ggcuaaucug uccgccagcg uggcgacagu ucagcuuccc      420

caacaggauc agccugugcc ccauggaacc cagugccugg ccaugggcug gggccggguc      480

ggggcucacg acccucccgc ccaagugcuc caggagcuga acgugacagu cguuaccuuc      540

uuuugucgcc cgcauaauau cugcacauuc gugccuagac ggaaagcugg aauuuguuuu      600

ggcgauucug ggggaccccu gaucugcgac ggcaucauuc aggggaucga uuccuucgug      660

auuuggggau gugccacccg ccucuuuccu gacuucuuua cgagagucgc ccuguacgug      720

gauuggaucc ggagcacccu ucgcagaguu gaagcuaagg gccggcccug a               771


<210>  3226
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSA__Homo_sapiens__P55786

<400>  3226

Met Trp Leu Ala Ala Ala Ala Pro Ser Leu Ala Arg Arg Leu Leu Phe 
1               5                   10                  15      


Leu Gly Pro Pro Pro Pro Pro Leu Leu Leu Leu Val Phe Ser Arg Ser 
            20                  25                  30          


Ser Arg Arg Arg Leu His Ser Leu Gly Leu Ala Ala Met Pro Glu Lys 
        35                  40                  45              


Arg Pro Phe Glu Arg Leu Pro Ala Asp Val Ser Pro Ile Asn Tyr Ser 
    50                  55                  60                  


Leu Cys Leu Lys Pro Asp Leu Leu Asp Phe Thr Phe Glu Gly Lys Leu 
65                  70                  75                  80  


Glu Ala Ala Ala Gln Val Arg Gln Ala Thr Asn Gln Ile Val Met Asn 
                85                  90                  95      


Cys Ala Asp Ile Asp Ile Ile Thr Ala Ser Tyr Ala Pro Glu Gly Asp 
            100                 105                 110         


Glu Glu Ile His Ala Thr Gly Phe Asn Tyr Gln Asn Glu Asp Glu Lys 
        115                 120                 125             


Val Thr Leu Ser Phe Pro Ser Thr Leu Gln Thr Gly Thr Gly Thr Leu 
    130                 135                 140                 


Lys Ile Asp Phe Val Gly Glu Leu Asn Asp Lys Met Lys Gly Phe Tyr 
145                 150                 155                 160 


Arg Ser Lys Tyr Thr Thr Pro Ser Gly Glu Val Arg Tyr Ala Ala Val 
                165                 170                 175     


Thr Gln Phe Glu Ala Thr Asp Ala Arg Arg Ala Phe Pro Cys Trp Asp 
            180                 185                 190         


Glu Pro Ala Ile Lys Ala Thr Phe Asp Ile Ser Leu Val Val Pro Lys 
        195                 200                 205             


Asp Arg Val Ala Leu Ser Asn Met Asn Val Ile Asp Arg Lys Pro Tyr 
    210                 215                 220                 


Pro Asp Asp Glu Asn Leu Val Glu Val Lys Phe Ala Arg Thr Pro Val 
225                 230                 235                 240 


Met Ser Thr Tyr Leu Val Ala Phe Val Val Gly Glu Tyr Asp Phe Val 
                245                 250                 255     


Glu Thr Arg Ser Lys Asp Gly Val Cys Val Arg Val Tyr Thr Pro Val 
            260                 265                 270         


Gly Lys Ala Glu Gln Gly Lys Phe Ala Leu Glu Val Ala Ala Lys Thr 
        275                 280                 285             


Leu Pro Phe Tyr Lys Asp Tyr Phe Asn Val Pro Tyr Pro Leu Pro Lys 
    290                 295                 300                 


Ile Asp Leu Ile Ala Ile Ala Asp Phe Ala Ala Gly Ala Met Glu Asn 
305                 310                 315                 320 


Trp Gly Leu Val Thr Tyr Arg Glu Thr Ala Leu Leu Ile Asp Pro Lys 
                325                 330                 335     


Asn Ser Cys Ser Ser Ser Arg Gln Trp Val Ala Leu Val Val Gly His 
            340                 345                 350         


Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp Trp 
        355                 360                 365             


Thr His Leu Trp Leu Asn Glu Gly Phe Ala Ser Trp Ile Glu Tyr Leu 
    370                 375                 380                 


Cys Val Asp His Cys Phe Pro Glu Tyr Asp Ile Trp Thr Gln Phe Val 
385                 390                 395                 400 


Ser Ala Asp Tyr Thr Arg Ala Gln Glu Leu Asp Ala Leu Asp Asn Ser 
                405                 410                 415     


His Pro Ile Glu Val Ser Val Gly His Pro Ser Glu Val Asp Glu Ile 
            420                 425                 430         


Phe Asp Ala Ile Ser Tyr Ser Lys Gly Ala Ser Val Ile Arg Met Leu 
        435                 440                 445             


His Asp Tyr Ile Gly Asp Lys Asp Phe Lys Lys Gly Met Asn Met Tyr 
    450                 455                 460                 


Leu Thr Lys Phe Gln Gln Lys Asn Ala Ala Thr Glu Asp Leu Trp Glu 
465                 470                 475                 480 


Ser Leu Glu Asn Ala Ser Gly Lys Pro Ile Ala Ala Val Met Asn Thr 
                485                 490                 495     


Trp Thr Lys Gln Met Gly Phe Pro Leu Ile Tyr Val Glu Ala Glu Gln 
            500                 505                 510         


Val Glu Asp Asp Arg Leu Leu Arg Leu Ser Gln Lys Lys Phe Cys Ala 
        515                 520                 525             


Gly Gly Ser Tyr Val Gly Glu Asp Cys Pro Gln Trp Met Val Pro Ile 
    530                 535                 540                 


Thr Ile Ser Thr Ser Glu Asp Pro Asn Gln Ala Lys Leu Lys Ile Leu 
545                 550                 555                 560 


Met Asp Lys Pro Glu Met Asn Val Val Leu Lys Asn Val Lys Pro Asp 
                565                 570                 575     


Gln Trp Val Lys Leu Asn Leu Gly Thr Val Gly Phe Tyr Arg Thr Gln 
            580                 585                 590         


Tyr Ser Ser Ala Met Leu Glu Ser Leu Leu Pro Gly Ile Arg Asp Leu 
        595                 600                 605             


Ser Leu Pro Pro Val Asp Arg Leu Gly Leu Gln Asn Asp Leu Phe Ser 
    610                 615                 620                 


Leu Ala Arg Ala Gly Ile Ile Ser Thr Val Glu Val Leu Lys Val Met 
625                 630                 635                 640 


Glu Ala Phe Val Asn Glu Pro Asn Tyr Thr Val Trp Ser Asp Leu Ser 
                645                 650                 655     


Cys Asn Leu Gly Ile Leu Ser Thr Leu Leu Ser His Thr Asp Phe Tyr 
            660                 665                 670         


Glu Glu Ile Gln Glu Phe Val Lys Asp Val Phe Ser Pro Ile Gly Glu 
        675                 680                 685             


Arg Leu Gly Trp Asp Pro Lys Pro Gly Glu Gly His Leu Asp Ala Leu 
    690                 695                 700                 


Leu Arg Gly Leu Val Leu Gly Lys Leu Gly Lys Ala Gly His Lys Ala 
705                 710                 715                 720 


Thr Leu Glu Glu Ala Arg Arg Arg Phe Lys Asp His Val Glu Gly Lys 
                725                 730                 735     


Gln Ile Leu Ser Ala Asp Leu Arg Ser Pro Val Tyr Leu Thr Val Leu 
            740                 745                 750         


Lys His Gly Asp Gly Thr Thr Leu Asp Ile Met Leu Lys Leu His Lys 
        755                 760                 765             


Gln Ala Asp Met Gln Glu Glu Lys Asn Arg Ile Glu Arg Val Leu Gly 
    770                 775                 780                 


Ala Thr Leu Leu Pro Asp Leu Ile Gln Lys Val Leu Thr Phe Ala Leu 
785                 790                 795                 800 


Ser Glu Glu Val Arg Pro Gln Asp Thr Val Ser Val Ile Gly Gly Val 
                805                 810                 815     


Ala Gly Gly Ser Lys His Gly Arg Lys Ala Ala Trp Lys Phe Ile Lys 
            820                 825                 830         


Asp Asn Trp Glu Glu Leu Tyr Asn Arg Tyr Gln Gly Gly Phe Leu Ile 
        835                 840                 845             


Ser Arg Leu Ile Lys Leu Ser Val Glu Gly Phe Ala Val Asp Lys Met 
    850                 855                 860                 


Ala Gly Glu Val Lys Ala Phe Phe Glu Ser His Pro Ala Pro Ser Ala 
865                 870                 875                 880 


Glu Arg Thr Ile Gln Gln Cys Cys Glu Asn Ile Leu Leu Asn Ala Ala 
                885                 890                 895     


Trp Leu Lys Arg Asp Ala Glu Ser Ile His Gln Tyr Leu Leu Gln Arg 
            900                 905                 910         


Lys Ala Ser Pro Pro Thr Val 
        915                 


<210>  3227
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSA__Homo_sapiens__CCDS45721.1

<400>  3227
auguggcugg cagcugccgc ccccucccuc gcucgccgcc ugcucuuccu cggcccuccg       60

ccuccucccc uccuccuucu cgucuucagc cgcuccucuc gccgccgccu ccacagccug      120

ggccucgccg cgaugccgga gaagaggccc uucgagcggc ugccugccga ugucuccccc      180

aucaacuaca gccuuugccu caagcccgac uugcuggacu ucaccuucga gggcaagcug      240

gaggccgccg cccaggugag gcaggcgacu aaucagauug ugaugaauug ugcugauauu      300

gauauuauua cagcuucaua ugcaccagaa ggagaugaag aaauacaugc uacaggauuu      360

aacuaucaga augaagauga aaaagucacc uugucuuucc cuaguacucu gcaaacaggu      420

acgggaaccu uaaagauaga uuuuguugga gagcugaaug acaaaaugaa agguuucuau      480

agaaguaaau auacuacccc uucuggagag gugcgcuaug cugcuguaac acaguuugag      540

gcuacugaug cccgaagggc uuuuccuugc ugggaugagc cugcuaucaa agcaacuuuu      600

gauaucucau ugguuguucc uaaagacaga guagcuuuau caaacaugaa uguaauugac      660

cggaaaccau acccugauga ugaaaauuua guggaaguga aguuugcccg cacaccuguu      720

augucuacau aucugguggc auuuguugug ggugaauaug acuuuguaga aacaagguca      780

aaagauggug uguguguccg uguuuacacu ccuguuggca aagcagagca aggaaaauuu      840

gcguuagagg uugcugcuaa aaccuugccu uuuuauaagg acuacuucaa uguuccuuau      900

ccucuaccua aaauugaucu cauugcuauu gcagacuuug cagcuggugc cauggagaac      960

uggggccuug uuacuuauag ggagacugca uugcuuauug auccaaaaaa uuccuguucu     1020

ucaucccgcc aguggguugc ucugguugug ggacaugaac ucgcccauca augguuugga     1080

aaucuuguua cuauggaaug guggacucau cuuugguuaa augaagguuu ugcauccugg     1140

auugaauauc uguguguaga ccacugcuuc ccagaguaug auauuuggac ucaguuuguu     1200

ucugcugauu acacccgugc ccaggagcuu gacgccuuag auaacagcca uccuauugaa     1260

gucagugugg gccauccauc ugagguugau gagauauuug augcuauauc auauagcaaa     1320

ggugcaucug ucauccgaau gcugcaugac uacauugggg auaaggacuu uaagaaagga     1380

augaacaugu auuuaaccaa guuccaacaa aagaaugcug ccacagagga ucucugggaa     1440

aguuuagaaa augcuagugg uaaaccuaua gcagcuguga ugaauaccug gaccaaacaa     1500

augggauuuc cccucauuua uguggaagcu gaacagguag aagaugacag auuauugagg     1560

uugucccaaa agaaguucug ugcugguggg ucauauguug gugaagauug uccccagugg     1620

auggucccua ucacaaucuc uacuagugaa gaccccaacc aggccaaacu aaaaauucua     1680

auggacaagc cagagaugaa ugugguuuug aaaaauguca aaccagacca augggugaag     1740

uuaaacuuag gaacaguugg guuuuaucgg acccaguaca gcucugccau gcuggaaagu     1800

uuauuaccag gcauucguga ccuuucucug cccccugugg aucgacuugg auuacagaau     1860

gaccucuucu ccuuggcucg agcuggaauc auuagcacug uagagguucu aaaagucaug     1920

gaggcuuuug ugaaugagcc caauuauacu guauggagcg accugagcug uaaccugggg     1980

auucucucaa cucucuuguc ccacacagac uucuaugagg aaauccagga guuugugaaa     2040

gaugucuuuu caccuauagg ggagagacug ggcugggacc ccaaaccugg agaaggucau     2100

cucgaugcac uccugagggg cuugguucug ggaaaacuag gaaaagcagg acauaaggca     2160

acguuagaag aagcccgucg ucgguuuaag gaccacgugg aaggaaaaca gauucucucc     2220

gcugaucuga ggaguccugu cuaucugacu guuuugaagc auggugaugg cacuacuuua     2280

gauauuaugu uaaaacuuca uaaacaagca gauaugcaag aagagaaaaa ccgaaucgaa     2340

agaguccuug gcgcuacucu uuugccugac cugauucaaa aaguccucac guuugcacuu     2400

ucagaagagg uacguccaca ggacacugua ucgguaauug guggaguagc uggaggcagc     2460

aagcauggua ggaaagcugc uuggaaauuc auaaaggaca acugggaaga acuuuauaac     2520

cgauaccagg gaggauucuu aauauccaga cuaauaaagc uaucaguuga gggauuugca     2580

guugauaaaa uggcuggaga gguuaaggcu uucuucgaga gucacccagc uccuucagcu     2640

gagcguacca uccagcagug uugugaaaau auucugcuga augcugccug gcuaaagcga     2700

gaugcugaga gcauccacca guaccuccuu cagcggaagg ccucaccacc cacaguguga     2760


<210>  3228
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSA__Homo_sapiens__CCDS45721.1

<400>  3228
auguggcugg ccgccgcggc ccccagccuc gcccgccggc ugcuguuccu cggcccgccc       60

ccgccgcccc ugcugcuccu gguguucucc cgcagcuccc ggcgccggcu gcacagccuc      120

gggcuggccg ccaugcccga gaagcgcccc uucgagcggc ugcccgcgga cgucuccccc      180

aucaacuaca gccucugccu gaagcccgac cugcucgacu ucaccuucga gggcaagcug      240

gaggccgccg cccaggugcg ccaggcgacc aaccagaucg ugaugaacug cgccgacauc      300

gacaucauca cggccuccua cgcccccgag ggggacgagg agauccacgc caccggcuuc      360

aacuaccaga acgaggacga gaaggucacc cugagcuucc ccuccacccu ccagacgggg      420

accggcaccc ugaagaucga cuucgugggc gagcugaacg acaagaugaa gggguucuac      480

cggagcaagu acaccacgcc guccggcgag gugcgcuacg cggccgucac ccaguucgag      540

gccaccgacg cccggcgcgc cuuccccugc ugggacgagc ccgcgaucaa ggccaccuuc      600

gacaucagcc ucguggugcc caaggaccgg gucgcccugu ccaacaugaa cgugaucgac      660

cgcaagccgu accccgacga cgagaaccug guggagguca aguucgcccg gacgcccgug      720

augagcaccu accucguggc cuucgucgug ggggaguacg acuucgugga gacccgcucc      780

aaggacggcg ucugcgugcg gguguacacc cccgucggga aggcggagca gggcaaguuc      840

gcccuggagg uggccgccaa gacgcugccg uucuacaagg acuacuucaa cgugcccuac      900

ccccucccca agaucgaccu gaucgccauc gcggacuucg ccgccggcgc cauggagaac      960

ugggggcugg ucaccuaccg cgagaccgcg cuccugaucg acccgaagaa cagcugcucc     1020

agcucccggc aguggguggc ccuggucgug ggccacgagc ucgcccacca gugguucggg     1080

aaccugguga ccauggagug guggacgcac cuguggcuca acgagggcuu cgccagcugg     1140

aucgaguacc ugugcgucga ccacugcuuc cccgaguacg acaucuggac ccaguucgug     1200

agcgccgacu acacccgcgc gcaggagcug gacgcccucg acaacuccca ccccaucgag     1260

gugagcgucg gccaccccuc cgagguggac gagaucuucg acgccaucag cuacuccaag     1320

ggggccagcg ugauccggau gcugcacgac uacaucggcg acaaggacuu caagaagggg     1380

augaacaugu accugaccaa guuccagcag aagaacgccg cgacggagga ccucugggag     1440

ucccuggaga acgccagcgg caagccgauc gccgccguca ugaacaccug gaccaagcag     1500

augggguucc cccugaucua cguggaggcc gagcaggucg aggacgaccg ccuccugcgc     1560

cugucccaga agaaguucug cgcgggcggc agcuacgugg gggaggacug cccccagugg     1620

auggugccga ucaccaucuc cacgagcgag gaccccaacc aggccaagcu caagauccug     1680

auggacaagc ccgagaugaa cgugguccug aagaacguga agcccgacca gugggugaag     1740

cugaaccucg gcaccgucgg guucuaccgg acccaguacu ccagcgccau gcuggagucc     1800

cugcucccgg gcauccgcga ccugagccug ccgcccgugg accggcucgg gcugcagaac     1860

gaccuguucu cccucgcccg cgcgggcauc aucagcaccg uggagguccu gaaggugaug     1920

gaggccuucg ugaacgagcc caacuacacg gucugguccg accugagcug caaccucggc     1980

auccugagca cccugcucuc ccacaccgac uucuacgagg agauccagga guucgugaag     2040

gacguguuca gccccaucgg ggagcggcug ggcugggacc ccaagcccgg ggagggccac     2100

cuggacgccc uccugcgcgg gcugguccuc ggcaagcugg gcaaggccgg gcacaaggcc     2160

acccuggagg aggcgcggcg ccgguucaag gaccacgugg agggcaagca gauccucucc     2220

gccgaccugc gcagccccgu guaccugacg guccucaagc acggggacgg caccacccug     2280

gacaucaugc ugaagcucca caagcaggcc gacaugcagg aggagaagaa ccggaucgag     2340

cgcgugcugg gcgccacccu gcucccggac cugauccaga aggugcugac cuucgcccuc     2400

uccgaggagg uccggcccca ggacacggug agcgugaucg ggggcgucgc cgggggcucc     2460

aagcacgggc gcaaggcggc cuggaaguuc aucaaggaca acugggagga gcuguacaac     2520

cgguaccagg gcggcuuccu gaucagccgc cucaucaagc uguccgugga gggguucgcc     2580

guggacaaga uggccggcga ggucaaggcg uucuucgaga gccaccccgc ccccuccgcc     2640

gagcggacca uccagcagug cugcgagaac auccugcuca acgccgcgug gcugaagcgc     2700

gacgccgaga gcauccacca guaccugcuc cagcggaagg ccuccccgcc caccguguga     2760


<210>  3229
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSA__Homo_sapiens__CCDS45721.1

<400>  3229
auguggcucg ccgccgccgc ccccucccuc gcccgccgcc uccucuuccu cggccccccc       60

cccccccccc uccuccuccu cgucuucucc cgcuccuccc gccgccgccu ccacucccuc      120

ggccucgccg ccaugcccga gaagcgcccc uucgagcgcc uccccgccga cgucuccccc      180

aucaacuacu cccucugccu caagcccgac cuccucgacu ucaccuucga gggcaagcuc      240

gaggccgccg cccagguccg ccaggccacc aaccagaucg ucaugaacug cgccgacauc      300

gacaucauca ccgccuccua cgcccccgag ggcgacgagg agauccacgc caccggcuuc      360

aacuaccaga acgaggacga gaaggucacc cucuccuucc ccuccacccu ccagaccggc      420

accggcaccc ucaagaucga cuucgucggc gagcucaacg acaagaugaa gggcuucuac      480

cgcuccaagu acaccacccc cuccggcgag guccgcuacg ccgccgucac ccaguucgag      540

gccaccgacg cccgccgcgc cuuccccugc ugggacgagc ccgccaucaa ggccaccuuc      600

gacaucuccc ucgucguccc caaggaccgc gucgcccucu ccaacaugaa cgucaucgac      660

cgcaagcccu accccgacga cgagaaccuc gucgagguca aguucgcccg cacccccguc      720

auguccaccu accucgucgc cuucgucguc ggcgaguacg acuucgucga gacccgcucc      780

aaggacggcg ucugcguccg cgucuacacc cccgucggca aggccgagca gggcaaguuc      840

gcccucgagg ucgccgccaa gacccucccc uucuacaagg acuacuucaa cguccccuac      900

ccccucccca agaucgaccu caucgccauc gccgacuucg ccgccggcgc cauggagaac      960

uggggccucg ucaccuaccg cgagaccgcc cuccucaucg accccaagaa cuccugcucc     1020

uccucccgcc agugggucgc ccucgucguc ggccacgagc ucgcccacca gugguucggc     1080

aaccucguca ccauggagug guggacccac cucuggcuca acgagggcuu cgccuccugg     1140

aucgaguacc ucugcgucga ccacugcuuc cccgaguacg acaucuggac ccaguucguc     1200

uccgccgacu acacccgcgc ccaggagcuc gacgcccucg acaacuccca ccccaucgag     1260

gucuccgucg gccaccccuc cgaggucgac gagaucuucg acgccaucuc cuacuccaag     1320

ggcgccuccg ucauccgcau gcuccacgac uacaucggcg acaaggacuu caagaagggc     1380

augaacaugu accucaccaa guuccagcag aagaacgccg ccaccgagga ccucugggag     1440

ucccucgaga acgccuccgg caagcccauc gccgccguca ugaacaccug gaccaagcag     1500

augggcuucc cccucaucua cgucgaggcc gagcaggucg aggacgaccg ccuccuccgc     1560

cucucccaga agaaguucug cgccggcggc uccuacgucg gcgaggacug cccccagugg     1620

auggucccca ucaccaucuc caccuccgag gaccccaacc aggccaagcu caagauccuc     1680

auggacaagc ccgagaugaa cgucguccuc aagaacguca agcccgacca gugggucaag     1740

cucaaccucg gcaccgucgg cuucuaccgc acccaguacu ccuccgccau gcucgagucc     1800

cuccuccccg gcauccgcga ccucucccuc ccccccgucg accgccucgg ccuccagaac     1860

gaccucuucu cccucgcccg cgccggcauc aucuccaccg ucgagguccu caaggucaug     1920

gaggccuucg ucaacgagcc caacuacacc gucugguccg accucuccug caaccucggc     1980

auccucucca cccuccucuc ccacaccgac uucuacgagg agauccagga guucgucaag     2040

gacgucuucu cccccaucgg cgagcgccuc ggcugggacc ccaagcccgg cgagggccac     2100

cucgacgccc uccuccgcgg ccucguccuc ggcaagcucg gcaaggccgg ccacaaggcc     2160

acccucgagg aggcccgccg ccgcuucaag gaccacgucg agggcaagca gauccucucc     2220

gccgaccucc gcucccccgu cuaccucacc guccucaagc acggcgacgg caccacccuc     2280

gacaucaugc ucaagcucca caagcaggcc gacaugcagg aggagaagaa ccgcaucgag     2340

cgcguccucg gcgccacccu ccuccccgac cucauccaga agguccucac cuucgcccuc     2400

uccgaggagg uccgccccca ggacaccguc uccgucaucg gcggcgucgc cggcggcucc     2460

aagcacggcc gcaaggccgc cuggaaguuc aucaaggaca acugggagga gcucuacaac     2520

cgcuaccagg gcggcuuccu caucucccgc cucaucaagc ucuccgucga gggcuucgcc     2580

gucgacaaga uggccggcga ggucaaggcc uucuucgagu cccaccccgc ccccuccgcc     2640

gagcgcacca uccagcagug cugcgagaac auccuccuca acgccgccug gcucaagcgc     2700

gacgccgagu ccauccacca guaccuccuc cagcgcaagg ccuccccccc caccgucuga     2760


<210>  3230
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSA__Homo_sapiens__CCDS45721.1

<400>  3230
auguggcugg ccgcugcagc ccccagccuc gcgagaaggc uucuguucuu gggcccucca       60

ccgcccccuu uacugcuacu cguguuuucc cggucuucac gccgacgucu gcacagucuu      120

gggcuggcug ccaugccaga gaagagaccc uucgaaaggu ugccugcaga cgucagccca      180

aucaacuacu cccucugccu gaaacccgau cugcucgacu uuaccuucga gggaaaguua      240

gaagccgcug cacagguucg gcaagccaca aaucagauug ugaugaacug ugcugauaua      300

gacaucauua cugccucuua ugcgccugag ggugaugaag agauccaugc aacgggcuuu      360

aauuaccaga acgaggacga aaaaguaacc cugucguucc caucaacacu ucagacuggg      420

accggaacau ugaagauuga uuuugugggc gagcugaaug acaaaaugaa ggguuucuau      480

cgcagcaagu acaccacucc gaguggggaa gucagauaug ccgcugugac acaauuugag      540

gccaccgaug caaggcgggc uuuccccugc ugggacgagc cugccaucaa agcgacguuu      600

gauauauccc uaguugugcc aaaggaccgc gucgcccucu cuaacaugaa ugugaucgau      660

cgaaaacccu acccugacga cgaaaaccug guagagguua aguucgcaag aacuccagug      720

augagcaccu aucuugucgc uuuuguggug ggagaauacg auuucgucga gacaaggucc      780

aaagacggcg uuugugugcg gguauacacu cccgugggca aggccgaaca ggggaaguuc      840

gcucuggagg ucgccgcaaa aaccuugccg uuuuauaagg auuacuucaa ugugccuuau      900

ccccucccaa aaauugaccu gaucgccauu gcugauuuug cggcaggagc cauggagaac      960

ugggguuuag uuacauaccg ugaaaccgcu cugcucaucg acccuaaaaa uucaugcagu     1020

agcucucgcc aguggguggc ccuugucgug ggccacgagc uggcacauca gugguucggg     1080

aacuugguaa cgauggaaug guggacucac cuauggcuga augagggauu ugccuccugg     1140

auagaauauc ucuguguuga ucauugcuuc cccgaguacg acauuuggac acaauuugug     1200

ucagcugauu auaccagagc ccaggagcug gacgcacuug auaacagcca cccaaucgaa     1260

gucagugugg gccaccccuc ugaggucgac gaaauuuucg acgcgaucuc cuacagcaag     1320

ggugcuucgg ugaucaggau gcugcaugau uacauugggg acaaggauuu uaaaaaggga     1380

augaauaugu auuugacuaa guuccagcag aaaaacgccg caacagagga ccucugggaa     1440

ucucuggaga acgccuccgg caagccuaua gcugccguua ugaauaccug gacgaaacaa     1500

augggcuuuc cauuaaucua cguggaggca gaacagguag aggaugaccg gcugcuacga     1560

cucucacaga agaaauucug ugcuggggga aguuaugucg gugaagauug cccgcaaugg     1620

auggugccca uuaccaucag cacauccgag gacccuaacc aggccaagcu gaagauacuu     1680

auggauaaac cagagaugaa uguuguguug aagaacguca aacccgacca gugggugaag     1740

cugaaucucg gcacuguagg guuuuaccgc acccaguauu cuagcgcgau gcuggaauca     1800

cuucugccug gaauuagaga uuugagucuc ccacccgugg acaggcuggg cuuacaaaac     1860

gaucuguucu cccuagcccg ggcugguauc aucagcacag uugagguccu caaagugaug     1920

gaagcauucg ugaaugagcc gaacuacacu gucuggucug accugucaug uaaucuuggg     1980

auuuugagua cccugcucag ccacacagac uuuuaugaag agauccagga guucguuaag     2040

gauguguuuu ccccuauugg cgaacgccug ggaugggacc caaagcccgg cgaggggcau     2100

uuagaugccc ugcuuagagg auuggugcuc gguaaacugg gcaaggcugg gcacaaagcc     2160

acccuagaag aggcaaggcg ucgguucaag gaccacguag aaggaaaaca gauacugucu     2220

gcggaucucc gaucgccugu cuaccugacu gugcuuaagc auggcgacgg uacgacauug     2280

gauaucaugc ugaaguuaca caaacaggcc gacaugcaag aggagaagaa cagaauugaa     2340

aggguucucg gggcuacccu gcuucccgau cugauccaga aaguguugac uuuugcccuc     2400

agcgaggaag uccgcccaca ggacaccgug uccguuaucg gcggaguggc aggcggguca     2460

aagcauggac ggaaagcugc cuggaaguuc auuaaagaua auugggagga acuguacaac     2520

agauaucagg guggcuuucu aauaaguagg cugaucaagc ucucuguaga gggguucgca     2580

gucgacaaga uggccggaga ggugaaagcg uuuuucgaaa gccacccugc ucccuccgcc     2640

gagcgcacaa uucaacagug cugugaaaau auccugcuua acgcagcuug guugaagcga     2700

gaugccgagu caauucauca guaccuguua cagcggaaag ccagcccacc gaccguguga     2760


<210>  3231
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSA__Homo_sapiens__CCDS45721.1

<400>  3231
auguggcugg ccgccgccgc ccccagccug gccagaagac ugcuguuccu gggccccccc       60

cccccccccc ugcugcugcu gguguucagc agaagcagca gaagaagacu gcacagccug      120

ggccuggccg ccaugcccga gaagagaccc uucgagagac ugcccgccga cgugagcccc      180

aucaacuaca gccugugccu gaagcccgac cugcuggacu ucaccuucga gggcaagcug      240

gaggccgccg cccaggugag acaggccacc aaccagaucg ugaugaacug cgccgacauc      300

gacaucauca ccgccagcua cgcccccgag ggcgacgagg agauccacgc caccggcuuc      360

aacuaccaga acgaggacga gaaggugacc cugagcuucc ccagcacccu gcagaccggc      420

accggcaccc ugaagaucga cuucgugggc gagcugaacg acaagaugaa gggcuucuac      480

agaagcaagu acaccacccc cagcggcgag gugagauacg ccgccgugac ccaguucgag      540

gccaccgacg ccagaagagc cuuccccugc ugggacgagc ccgccaucaa ggccaccuuc      600

gacaucagcc ugguggugcc caaggacaga guggcccuga gcaacaugaa cgugaucgac      660

agaaagcccu accccgacga cgagaaccug guggagguga aguucgccag aacccccgug      720

augagcaccu accugguggc cuucguggug ggcgaguacg acuucgugga gaccagaagc      780

aaggacggcg ugugcgugag aguguacacc cccgugggca aggccgagca gggcaaguuc      840

gcccuggagg uggccgccaa gacccugccc uucuacaagg acuacuucaa cgugcccuac      900

ccccugccca agaucgaccu gaucgccauc gccgacuucg ccgccggcgc cauggagaac      960

uggggccugg ugaccuacag agagaccgcc cugcugaucg accccaagaa cagcugcagc     1020

agcagcagac aguggguggc ccugguggug ggccacgagc uggcccacca gugguucggc     1080

aaccugguga ccauggagug guggacccac cuguggcuga acgagggcuu cgccagcugg     1140

aucgaguacc ugugcgugga ccacugcuuc cccgaguacg acaucuggac ccaguucgug     1200

agcgccgacu acaccagagc ccaggagcug gacgcccugg acaacagcca ccccaucgag     1260

gugagcgugg gccaccccag cgagguggac gagaucuucg acgccaucag cuacagcaag     1320

ggcgccagcg ugaucagaau gcugcacgac uacaucggcg acaaggacuu caagaagggc     1380

augaacaugu accugaccaa guuccagcag aagaacgccg ccaccgagga ccugugggag     1440

agccuggaga acgccagcgg caagcccauc gccgccguga ugaacaccug gaccaagcag     1500

augggcuucc cccugaucua cguggaggcc gagcaggugg aggacgacag acugcugaga     1560

cugagccaga agaaguucug cgccggcggc agcuacgugg gcgaggacug cccccagugg     1620

auggugccca ucaccaucag caccagcgag gaccccaacc aggccaagcu gaagauccug     1680

auggacaagc ccgagaugaa cguggugcug aagaacguga agcccgacca gugggugaag     1740

cugaaccugg gcaccguggg cuucuacaga acccaguaca gcagcgccau gcuggagagc     1800

cugcugcccg gcaucagaga ccugagccug ccccccgugg acagacuggg ccugcagaac     1860

gaccuguuca gccuggccag agccggcauc aucagcaccg uggaggugcu gaaggugaug     1920

gaggccuucg ugaacgagcc caacuacacc guguggagcg accugagcug caaccugggc     1980

auccugagca cccugcugag ccacaccgac uucuacgagg agauccagga guucgugaag     2040

gacguguuca gccccaucgg cgagagacug ggcugggacc ccaagcccgg cgagggccac     2100

cuggacgccc ugcugagagg ccuggugcug ggcaagcugg gcaaggccgg ccacaaggcc     2160

acccuggagg aggccagaag aagauucaag gaccacgugg agggcaagca gauccugagc     2220

gccgaccuga gaagccccgu guaccugacc gugcugaagc acggcgacgg caccacccug     2280

gacaucaugc ugaagcugca caagcaggcc gacaugcagg aggagaagaa cagaaucgag     2340

agagugcugg gcgccacccu gcugcccgac cugauccaga aggugcugac cuucgcccug     2400

agcgaggagg ugagacccca ggacaccgug agcgugaucg gcggcguggc cggcggcagc     2460

aagcacggca gaaaggccgc cuggaaguuc aucaaggaca acugggagga gcuguacaac     2520

agauaccagg gcggcuuccu gaucagcaga cugaucaagc ugagcgugga gggcuucgcc     2580

guggacaaga uggccggcga ggugaaggcc uucuucgaga gccaccccgc ccccagcgcc     2640

gagagaacca uccagcagug cugcgagaac auccugcuga acgccgccug gcugaagaga     2700

gacgccgaga gcauccacca guaccugcug cagagaaagg ccagcccccc caccguguga     2760


<210>  3232
<211>  2760
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSA__Homo_sapiens__CCDS45721.1

<400>  3232
auguggcugg ccgcugccgc gcccagccuc gcuagacggc ugcuuuuccu gggcccuccg       60

cccccucccc uccugcuucu gguguuuucc cgcucuagca gacggcgccu ccacucccug      120

gggcuggccg ccaugccuga gaagagaccc uucgaacggc ucccugcuga cgucucuccg      180

aucaacuaca gccugugccu uaaacccgau cugcucgacu uuaccuucga gggaaagcug      240

gaagccgcug cccagguucg ccaagcgaca aaucagauug ugaugaacug ugccgauauc      300

gacauuauca cggcuuccua ugccccugag ggcgaugaag agauucaugc uaccggguuu      360

aauuaccaga acgaggacga aaaagugaca cuuucuuucc ccagcacccu gcagacagga      420

accggcacac ucaagaucga uuuugucggg gagcugaaug acaaaaugaa gggauucuau      480

agauccaagu acaccacgcc uagcggcgaa gugcgguaug ccgcgguuac ccaauuugag      540

gccacagaug cucgcagagc cuuccccugc ugggacgagc cggcuaucaa agccaccuuu      600

gauauuucuc uggugguccc uaaggaccgg guggcccucu ccaacaugaa uguuaucgau      660

cgcaaacccu acccugacga cgaaaaccug guggagguca aguucgcuag aacacccgug      720

augagcaccu aucuuguggc guuugucguu ggcgaauacg auuucgugga gacgcggucu      780

aaagacgggg uguguguccg cguguacaca cccguuggaa aggccgaaca gggcaaguuc      840

gcucuggagg uggccgccaa aacccucccu uuuuauaagg auuacuucaa ugucccguau      900

ccccugccua aaauugaccu uaucgcuauu gccgauuuug cggcuggggc cauggagaac      960

uggggacugg ugacauacag agaaaccgcc cuccugaucg accccaagaa uagcugcucc     1020

ucuucccggc aguggguugc ucuggugguc ggccacgagc ucgcccauca gugguucggg     1080

aaccugguga ccauggaaug guggacacac cuuuggcuga augagggauu ugcuagcugg     1140

auugaauauc ucugugucga ucauugcuuc ccugaguacg acaucuggac gcaauuugug     1200

uccgccgauu auaccagagc gcaggagcug gacgcccuug auaacucuca ccccaucgaa     1260

guuagcgugg gccacccguc cgaggucgac gaaauuuucg acgcuaucag cuacucuaaa     1320

ggcgccuccg ugauucgcau gcugcaugau uacaucgggg acaaggauuu uaaaaaggga     1380

augaauaugu aucucacaaa guuccagcag aaaaacgcug ccaccgagga ccugugggaa     1440

agccuggaga acgcgucugg caagccuauu gccgcuguua ugaauacaug gaccaaacaa     1500

augggguuuc cccucaucua cguggaggcc gaacaggucg aggaugaccg gcugcuuaga     1560

cugagccaga agaaauucug ugcuggaggc uccuaugugg gggaagauug cccucaaugg     1620

auggugccca ucacgauuuc uacaagcgag gacccuaacc aggccaagcu caagauccug     1680

auggauaaac ccgagaugaa uguuguccug aagaacguga aaccggacca gugggugaaa     1740

cuuaaucucg gaaccgucgg cuuuuaccgc acccaguauu ccagcgccau gcuggaaucu     1800

cugcucccug gcauucggga ucugucccuu ccucccgugg acagacuggg gcuccaaaac     1860

gaucuguuca gccuggcucg cgcgggaauc auuucuacag uugaggugcu uaaggucaug     1920

gaagccuucg ugaaugagcc caacuacacc guuugguccg accucagcug uaaucugggc     1980

auccugucca cacuccuguc ucacacggac uuuuaugaag agauccagga guucgugaag     2040

gaugucuuua gcccgauugg ggaacggcuu ggaugggacc ccaagccugg cgaggggcau     2100

cuggaugcuc uccugagagg ccuggugcuu ggaaaacucg gcaaggccgg gcacaaagcc     2160

acccuggaag aggcucgccg gagauucaag gaccacguug aaggaaaaca gauccugucc     2220

gccgaucucc gcucucccgu guaccugaca guccuuaagc auggcgacgg gaccacacug     2280

gauauuaugc ucaagcugca caaacaggcg gacaugcaag aggagaagaa ccggaucgaa     2340

agagugcugg gagcuacccu ucucccugau cugauucaga aagugcugac guuugcccuc     2400

agcgaggaag uccggcccca ggacaccguu uccgugaucg gcgggguggc cggcggaagc     2460

aagcauggcc gcaaagcugc cuggaaguuc auuaaagaua auugggagga acuguacaac     2520

agauaucaag ggggauuucu uaucucucgg cugaucaagc ucuccgucga gggcuucgcg     2580

guggacaaga uggcugggga gguuaaagcc uuuuucgaaa gccacccugc ccccucugcu     2640

gagagaacaa uucagcagug cugugaaaau auccugcuga acgccgcuug gcuuaagcgc     2700

gaugccgagu ccauucauca guaccugcuc cagcggaaag cgagcccgcc uaccguguga     2760


<210>  3233
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSB9__Homo_sapiens__P28065

<400>  3233

Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu 
1               5                   10                  15      


Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val 
            20                  25                  30          


Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn 
        35                  40                  45              


Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala 
    50                  55                  60                  


Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala 
65                  70                  75                  80  


Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val 
                85                  90                  95      


Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu 
            100                 105                 110         


Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly 
        115                 120                 125             


Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe 
    130                 135                 140                 


Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala 
145                 150                 155                 160 


Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr 
                165                 170                 175     


Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val 
            180                 185                 190         


Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile 
        195                 200                 205             


Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu 
    210                 215                 


<210>  3234
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSB9__Homo_sapiens__AAH65513

<400>  3234
augcugcggg cgggagcacc aaccggggac uuaccccggg cgggagaagu ccacaccggg       60

accaccauca uggcagugga guuugacggg ggcguuguga uggguucuga uucccgagug      120

ucugcaggcg aggcgguggu gaaccgagug uuugacaagc uguccccgcu gcacgagcgc      180

aucuacugug cacucucugg uucagcugcu gaugcccaag ccguggccga cauggccgcc      240

uaccagcugg agcuccaugg gauagaacug gaggaaccuc cacuuguuuu ggcugcugca      300

aaugugguga gaaauaucag cuauaaauau cgagaggacu ugucugcaca ucucauggua      360

gcuggcuggg accaacguga aggaggucag guauauggaa cccugggagg aaugcugacu      420

cgacagccuu uugccauugg uggcuccggc agcaccuuua ucuaugguua uguggaugca      480

gcauauaagc caggcauguc ucccgaggag ugcaggcgcu ucaccacaga cgcuauugcu      540

cuggccauga gccgggaugg cucaagcggg ggugucaucu accuggucac uauuacagcu      600

gccggugugg accaucgagu caucuugggc aaugaacugc caaaauucua ugaugaguga      660


<210>  3235
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSB9__Homo_sapiens__AAH65513

<400>  3235
augcugcgcg ccggcgcccc caccggggac cucccgcggg cgggcgaggu gcacaccggg       60

acgaccauca uggccgucga guucgacggc ggggugguga ugggcagcga cucccgcguc      120

agcgccggcg aggccguggu gaaccggguc uucgacaagc ugagcccccu gcacgagcgc      180

aucuacugcg cccucuccgg guccgcggcc gacgcccagg ccguggcgga cauggccgcc      240

uaccagcugg agcugcacgg caucgagcuc gaggagccgc cccuggugcu ggccgccgcg      300

aacgucgugc ggaacaucag cuacaaguac cgcgaggacc ucuccgccca ccugauggug      360

gccggguggg accagcggga gggcgggcag gucuacggca cccugggcgg gaugcucacc      420

cgccagcccu ucgccaucgg cgggagcggc uccacguuca ucuacggcua cguggacgcc      480

gcguacaagc ccgggaugag ccccgaggag ugccggcgcu ucaccaccga cgccaucgcc      540

cuggccaugu cccgggacgg cagcuccggg ggcgugaucu accuggucac caucacggcc      600

gcgggggugg accaccgcgu gauccucggc aacgagcugc ccaaguucua cgacgaguga      660


<210>  3236
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSB9__Homo_sapiens__AAH65513

<400>  3236
augcuccgcg ccggcgcccc caccggcgac cucccccgcg ccggcgaggu ccacaccggc       60

accaccauca uggccgucga guucgacggc ggcgucguca ugggcuccga cucccgcguc      120

uccgccggcg aggccgucgu caaccgcguc uucgacaagc ucuccccccu ccacgagcgc      180

aucuacugcg cccucuccgg cuccgccgcc gacgcccagg ccgucgccga cauggccgcc      240

uaccagcucg agcuccacgg caucgagcuc gaggagcccc cccucguccu cgccgccgcc      300

aacgucgucc gcaacaucuc cuacaaguac cgcgaggacc ucuccgccca ccucaugguc      360

gccggcuggg accagcgcga gggcggccag gucuacggca cccucggcgg caugcucacc      420

cgccagcccu ucgccaucgg cggcuccggc uccaccuuca ucuacggcua cgucgacgcc      480

gccuacaagc ccggcauguc ccccgaggag ugccgccgcu ucaccaccga cgccaucgcc      540

cucgccaugu cccgcgacgg cuccuccggc ggcgucaucu accucgucac caucaccgcc      600

gccggcgucg accaccgcgu cauccucggc aacgagcucc ccaaguucua cgacgaguga      660


<210>  3237
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSB9__Homo_sapiens__AAH65513

<400>  3237
augcugagag ccggcgcucc caccggggac cucccuaggg caggagaggu gcacacaggu       60

acuacgauca uggccgucga guucgauggc gggguuguga ugggaagcga cucccgggua      120

ucugcgggcg aagcuguggu caaccgcgug uuugauaaac uuucaccacu gcaugaacga      180

auuuacugcg ccuugagugg uagcgcagcc gacgcucagg caguugccga uauggcugcc      240

uaucaauuag agcugcacgg gauagaacua gaggagccgc cccucgugcu ggcggcagcc      300

aaugucgugc guaacaucuc cuacaaguau agagaagacc uuucugcuca ucugauggua      360

gccggauggg aucagaggga gggcggccag guuuacggga ccuugggagg uaugcucaca      420

cggcagccuu ucgcaauugg cgggucggga ucaacuuuua ucuauggcua cguggacgcu      480

gccuauaagc cagguaugag ccccgaagag ugucgcagau ucaccacaga ugcgauugcc      540

cuggcaauga guagggacgg guccucugga ggcgucaucu accuggugac cauaacugcu      600

gccggcgugg aucaccgggu cauccucggg aaugaguuac cuaaauuuua cgacgaauga      660


<210>  3238
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSB9__Homo_sapiens__AAH65513

<400>  3238
augcugagag ccggcgcccc caccggcgac cugcccagag ccggcgaggu gcacaccggc       60

accaccauca uggccgugga guucgacggc ggcgugguga ugggcagcga cagcagagug      120

agcgccggcg aggccguggu gaacagagug uucgacaagc ugagcccccu gcacgagaga      180

aucuacugcg cccugagcgg cagcgccgcc gacgcccagg ccguggccga cauggccgcc      240

uaccagcugg agcugcacgg caucgagcug gaggagcccc cccuggugcu ggccgccgcc      300

aacgugguga gaaacaucag cuacaaguac agagaggacc ugagcgccca ccugauggug      360

gccggcuggg accagagaga gggcggccag guguacggca cccugggcgg caugcugacc      420

agacagcccu ucgccaucgg cggcagcggc agcaccuuca ucuacggcua cguggacgcc      480

gccuacaagc ccggcaugag ccccgaggag ugcagaagau ucaccaccga cgccaucgcc      540

cuggccauga gcagagacgg cagcagcggc ggcgugaucu accuggugac caucaccgcc      600

gccggcgugg accacagagu gauccugggc aacgagcugc ccaaguucua cgacgaguga      660


<210>  3239
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSB9__Homo_sapiens__AAH65513

<400>  3239
augcugagag ccggcgcucc caccggggac cucccucggg ccggagaggu gcacacaggc       60

acgaccauca uggcggucga guucgauggg ggaguuguga ugggcagcga cucccgcgug      120

ucugcugggg aggccgucgu gaacagaguu uuugauaagc ugagcccgcu ucaugaacgg      180

auuuacugcg cccuguccgg aucugcugcc gacgcucagg ccguggcgga uauggccgcu      240

uaucaacucg agcugcacgg caucgaacuu gaggagcccc cucugguccu cgccgcugcc      300

aaugugguuc gcaacauuag cuacaaauau agagaagacc uguccgcgca ucugauggug      360

gccggcuggg aucagcggga agggggacag gucuacggca cacucggggg aaugcugacc      420

cgccagcccu ucgcuaucgg cgggucugga agcacauuua uuuauggcua cguggacgcc      480

gcuuauaagc cuggcauguc ccccgaagag uguagacggu ucaccacaga ugccaucgcc      540

cuugcuauga gccgcgacgg gucuuccgga ggcgugaucu accuggucac cauuacggcg      600

gccgggguug aucacagagu gauccucgga aaugagcugc cuaaauuuua cgacgaauga      660


<210>  3240
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSCA__Homo_sapiens__D3DWI6

<400>  3240

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  3241
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSCA__Homo_sapiens__EAW82312

<400>  3241
auggcaggcu uggcccugca gccaggcacu gcccugcugu gcuacuccug caaagcccag       60

gugagcaacg aggacugccu gcagguggag aacugcaccc agcuggggga gcagugcugg      120

accgcgcgca uccgcgcagu uggccuccug accgucauca gcaaaggcug cagcuugaac      180

ugcguggaug acucacagga cuacuacgug ggcaagaaga acaucacgug cugugacacc      240

gacuugugca acgccagcgg ggcccaugcc cugcagccgg cugcugccau ccuugcgcug      300

cucccugcac ucggccugcu gcucugggga cccggccagc ucuag                      345


<210>  3242
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSCA__Homo_sapiens__EAW82312

<400>  3242
auggccggcc uggcccucca gcccgggacc gcgcugcugu gcuacagcug caaggcccag       60

guguccaacg aggacugccu ccaggucgag aacugcaccc agcugggcga gcagugcugg      120

accgcccgca uccgggccgu ggggcugcuc accgugauca gcaagggcug cucccugaac      180

ugcgucgacg acagccagga cuacuacgug gggaagaaga acaucacgug cugcgacacc      240

gaccugugca acgccuccgg cgcgcacgcc cuccagccgg ccgccgcgau ccuggcccug      300

cuccccgccc ugggccugcu ccuguggggg cccggccagc uguga                      345


<210>  3243
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSCA__Homo_sapiens__EAW82312

<400>  3243
auggccggcc ucgcccucca gcccggcacc gcccuccucu gcuacuccug caaggcccag       60

gucuccaacg aggacugccu ccaggucgag aacugcaccc agcucggcga gcagugcugg      120

accgcccgca uccgcgccgu cggccuccuc accgucaucu ccaagggcug cucccucaac      180

ugcgucgacg acucccagga cuacuacguc ggcaagaaga acaucaccug cugcgacacc      240

gaccucugca acgccuccgg cgcccacgcc cuccagcccg ccgccgccau ccucgcccuc      300

cuccccgccc ucggccuccu ccucuggggc cccggccagc ucuga                      345


<210>  3244
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSCA__Homo_sapiens__EAW82312

<400>  3244
auggccggcc uggcucucca gcccgggacc gcacuucugu gcuacagcug uaaggcccaa       60

guguccaacg aggacugcuu gcaggucgaa aauuguacac aguuaggaga gcagugcugg      120

acugcgagaa ucagggcugu uggucugcua acggugauuu cuaaaggcug uucacucaac      180

ugcguagaug acagucaaga uuauuacgug gggaagaaaa auauaaccug uugcgacaca      240

gaucugugua acgccagcgg agcacacgcc cuucagccug cugcagccau ccuggcuuug      300

cucccagccc ugggccugcu cuuauggggu ccggggcagc uguga                      345


<210>  3245
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSCA__Homo_sapiens__EAW82312

<400>  3245
auggccggcc uggcccugca gcccggcacc gcccugcugu gcuacagcug caaggcccag       60

gugagcaacg aggacugccu gcagguggag aacugcaccc agcugggcga gcagugcugg      120

accgccagaa ucagagccgu gggccugcug accgugauca gcaagggcug cagccugaac      180

ugcguggacg acagccagga cuacuacgug ggcaagaaga acaucaccug cugcgacacc      240

gaccugugca acgccagcgg cgcccacgcc cugcagcccg ccgccgccau ccuggcccug      300

cugcccgccc ugggccugcu gcuguggggc cccggccagc uguga                      345


<210>  3246
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSCA__Homo_sapiens__EAW82312

<400>  3246
auggccggcc uggcucucca gcccgggacc gcccugcuuu gcuacagcug uaaggcgcaa       60

guguccaacg aggacugccu gcaggucgaa aauuguacac agcucggaga gcagugcugg      120

acggcuagaa uccgggccgu uggccugcuu accgugauuu cuaaagggug uagccugaac      180

ugcguggaug acucccaaga uuauuacguc ggaaagaaaa auaucacaug uugcgacacc      240

gaucucugua acgccucugg cgcucacgcc cugcagccug cugccgcgau ucuggcccuc      300

cugccggcuc uugggcugcu ccugugggga cccggccagc uuuga                      345


<210>  3247
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSCA__Homo_sapiens__O43653

<400>  3247

Met Lys Ala Val Leu Leu Ala Leu Leu Met Ala Gly Leu Ala Leu Gln 
1               5                   10                  15      


Pro Gly Thr Ala Leu Leu Cys Tyr Ser Cys Lys Ala Gln Val Ser Asn 
            20                  25                  30          


Glu Asp Cys Leu Gln Val Glu Asn Cys Thr Gln Leu Gly Glu Gln Cys 
        35                  40                  45              


Trp Thr Ala Arg Ile Arg Ala Val Gly Leu Leu Thr Val Ile Ser Lys 
    50                  55                  60                  


Gly Cys Ser Leu Asn Cys Val Asp Asp Ser Gln Asp Tyr Tyr Val Gly 
65                  70                  75                  80  


Lys Lys Asn Ile Thr Cys Cys Asp Thr Asp Leu Cys Asn Ala Ser Gly 
                85                  90                  95      


Ala His Ala Leu Gln Pro Ala Ala Ala Ile Leu Ala Leu Leu Pro Ala 
            100                 105                 110         


Leu Gly Leu Leu Leu Trp Gly Pro Gly Gln Leu 
        115                 120             


<210>  3248
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSCA__Homo_sapiens__AAC39607

<400>  3248
augaaggcug ugcugcuugc ccuguugaug gcaggcuugg cccugcagcc aggcacugcc       60

cugcugugcu acuccugcaa agcccaggug agcaacgagg acugccugca gguggagaac      120

ugcacccagc ugggggagca gugcuggacc gcgcgcaucc gcgcaguugg ccuccugacc      180

gucaucagca aaggcugcag cuugaacugc guggaugacu cacaggacua cuacgugggc      240

aagaagaaca ucacgugcug ugacaccgac uugugcaacg ccagcggggc ccaugcccug      300

cagccggcug ccgccauccu ugcgcugcuc ccugcacucg gccugcugcu cuggggaccc      360

ggccagcuau ag                                                          372


<210>  3249
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSCA__Homo_sapiens__AAC39607

<400>  3249
augaaggccg ugcugcucgc ccugcugaug gcgggccucg cccugcagcc cgggaccgcc       60

cugcucugcu acagcugcaa ggcccagguc uccaacgagg acugccucca gguggagaac      120

ugcacccagc ugggcgagca gugcuggacc gcccgcaucc gggcgguggg gcugcugacc      180

gucaucagca agggcugcuc ccugaacugc guggacgaca gccaggacua cuacgugggg      240

aagaagaaca ucacgugcug cgacaccgac cucugcaacg ccuccggcgc ccacgcccug      300

cagccggcgg ccgccauccu ggcccuccug cccgcccugg gccuccugcu gugggggccc      360

ggccagcucu ga                                                          372


<210>  3250
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSCA__Homo_sapiens__AAC39607

<400>  3250
augaaggccg uccuccucgc ccuccucaug gccggccucg cccuccagcc cggcaccgcc       60

cuccucugcu acuccugcaa ggcccagguc uccaacgagg acugccucca ggucgagaac      120

ugcacccagc ucggcgagca gugcuggacc gcccgcaucc gcgccgucgg ccuccucacc      180

gucaucucca agggcugcuc ccucaacugc gucgacgacu cccaggacua cuacgucggc      240

aagaagaaca ucaccugcug cgacaccgac cucugcaacg ccuccggcgc ccacgcccuc      300

cagcccgccg ccgccauccu cgcccuccuc cccgcccucg gccuccuccu cuggggcccc      360

ggccagcucu ga                                                          372


<210>  3251
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSCA__Homo_sapiens__AAC39607

<400>  3251
augaaggccg ugcugcucgc acuucugaug gcuggcuugg ccuuacagcc cgggaccgcg       60

cugcuaugcu acagcuguaa agcucaaguc uccaacgagg acugccucca gguugaaaau      120

uguacacagc ugggagagca gugcuggacu gccagaauca gggcaguggg ucuucugacg      180

guaauuucua agggcuguuc auugaacugc guggaugaca gucaagauua uuacgucggg      240

aaaaagaaua uaaccuguug cgacacagau cucuguaacg ccagcggagc ucacgcacug      300

cagccugccg cugccauccu ggcgcucuua ccagcacugg gccuuuugcu gugggguccg      360

gggcagcuau ga                                                          372


<210>  3252
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSCA__Homo_sapiens__AAC39607

<400>  3252
augaaggccg ugcugcuggc ccugcugaug gccggccugg cccugcagcc cggcaccgcc       60

cugcugugcu acagcugcaa ggcccaggug agcaacgagg acugccugca gguggagaac      120

ugcacccagc ugggcgagca gugcuggacc gccagaauca gagccguggg ccugcugacc      180

gugaucagca agggcugcag ccugaacugc guggacgaca gccaggacua cuacgugggc      240

aagaagaaca ucaccugcug cgacaccgac cugugcaacg ccagcggcgc ccacgcccug      300

cagcccgccg ccgccauccu ggcccugcug cccgcccugg gccugcugcu guggggcccc      360

ggccagcugu ga                                                          372


<210>  3253
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSCA__Homo_sapiens__AAC39607

<400>  3253
augaaggccg ugcugcucgc ucugcuuaug gccggccugg cgcuccagcc cgggaccgcu       60

cugcuuugcu acagcuguaa agcccaaguc uccaacgagg acugccugca gguugaaaau      120

uguacacagc ucggagagca gugcuggacg gccagaaucc gggcuguggg ccugcugacc      180

gugauuucua agggguguag ccucaacugc gucgaugacu cccaagauua uuacgugggc      240

aaaaagaaua ucacauguug cgacaccgau cuguguaacg ccucuggagc ucacgcccuu      300

cagccugcgg ccgcuauucu ggcccuccug ccggcucuug ggcugcuccu guggggaccc      360

ggccagcugu ga                                                          372


<210>  3254
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSGR__Homo_sapiens__Q9H255

<400>  3254

Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile 
1               5                   10                  15      


Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser 
            20                  25                  30          


Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val 
        35                  40                  45              


Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 
    50                  55                  60                  


Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 
65                  70                  75                  80  


Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys 
                85                  90                  95      


Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 
            100                 105                 110         


Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 
    130                 135                 140                 


Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu 
145                 150                 155                 160 


Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 
                165                 170                 175     


Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu 
            180                 185                 190         


Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 
        195                 200                 205             


Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 
    210                 215                 220                 


Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 
225                 230                 235                 240 


Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 
                245                 250                 255     


Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg 
            260                 265                 270         


Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 
        275                 280                 285             


Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala 
    290                 295                 300                 


Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys 
305                 310                 315                 320 






<210>  3255
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSGR__Homo_sapiens__AAG40776

<400>  3255
augaguuccu gcaacuucac acaugccacc uuugugcuua uugguauccc aggauuagag       60

aaagcccauu ucuggguugg cuucccccuc cuuuccaugu auguaguggc aauguuugga      120

aacugcaucg uggucuucau cguaaggacg gaacgcagcc ugcacgcucc gauguaccuc      180

uuucucugca ugcuugcagc cauugaccug gccuuaucca cauccaccau gccuaagauc      240

cuugcccuuu ucugguuuga uucccgagag auuagcuuug aggccugucu uacccagaug      300

uucuuuauuc augcccucuc agccauugaa uccaccaucc ugcuggccau ggccuuugac      360

cguuaugugg ccaucugcca cccacugcgc caugcugcag ugcucaacaa uacaguaaca      420

gcccagauug gcaucguggc ugugguccgc ggaucccucu uuuuuuuccc acugccucug      480

cugaucaagc ggcuggccuu cugccacucc aauguccucu cgcacuccua uuguguccac      540

caggauguaa ugaaguuggc cuaugcagac acuuugccca augugguaua uggucuuacu      600

gccauucugc uggucauggg cguggacgua auguucaucu ccuuguccua uuuucugaua      660

auacgaacgg uucugcaacu gccuuccaag ucagagcggg ccaaggccuu uggaaccugu      720

gugucacaca uugguguggu acucgccuuc uaugugccac uuauuggccu cucaguugua      780

caccgcuuug gaaacagccu ucaucccauu gugcguguug ucauggguga caucuaccug      840

cugcugccuc cugucaucaa ucccaucauc uauggugcca aaaccaaaca gaucagaaca      900

cgggugcugg cuauguucaa gaucagcugu gacaaggacu ugcaggcugu gggaggcaag      960

uga                                                                    963


<210>  3256
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSGR__Homo_sapiens__AAG40776

<400>  3256
augagcuccu gcaacuucac ccacgccacc uucgugcuga ucggcauccc cgggcucgag       60

aaggcccacu ucugggucgg cuucccgcug cugagcaugu acgugguggc gauguucggg      120

aacugcaucg ucguguucau cgugcgcacg gagcgguccc uccacgcccc cauguaccug      180

uuccugugca ugcucgccgc caucgaccug gcccugagca ccuccaccau gcccaagauc      240

cucgcgcugu ucugguucga cagccgcgag aucuccuucg aggccugccu gacccagaug      300

uucuucaucc acgcccucag cgccaucgag uccacgaucc ugcuggcgau ggccuucgac      360

cgguacgucg ccaucugcca cccccuccgc cacgccgccg ugcugaacaa caccgugacc      420

gcgcagaucg gcaucgucgc cguggugcgg gggagccugu ucuucuuccc gcucccccug      480

cugaucaagc gccucgccuu cugccacucc aacguccuga gccacuccua cugcgugcac      540

caggacguga ugaagcuggc cuacgccgac acccucccca acgucgugua cggccugacg      600

gcgauccugc ucgugauggg cgucgacgug auguucauca gccuguccua cuuccugauc      660

auccggaccg ugcuccagcu gcccagcaag uccgagcgcg ccaaggccuu cgggaccugc      720

gucagccaca ucggcguggu gcuggccuuc uacgucccgc ucaucgggcu guccgugguc      780

caccgguucg gcaacagccu gcaccccauc gugcgcgugg ucauggggga caucuaccuc      840

cugcugccgc ccgugaucaa ccccaucauc uacggcgcca agaccaagca gauccggacg      900

cgcgugcucg cgauguucaa gaucagcugc gacaaggacc ugcaggccgu cggcgggaag      960

uga                                                                    963


<210>  3257
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSGR__Homo_sapiens__AAG40776

<400>  3257
auguccuccu gcaacuucac ccacgccacc uucguccuca ucggcauccc cggccucgag       60

aaggcccacu ucugggucgg cuucccccuc cucuccaugu acgucgucgc cauguucggc      120

aacugcaucg ucgucuucau cguccgcacc gagcgcuccc uccacgcccc cauguaccuc      180

uuccucugca ugcucgccgc caucgaccuc gcccucucca ccuccaccau gcccaagauc      240

cucgcccucu ucugguucga cucccgcgag aucuccuucg aggccugccu cacccagaug      300

uucuucaucc acgcccucuc cgccaucgag uccaccaucc uccucgccau ggccuucgac      360

cgcuacgucg ccaucugcca cccccuccgc cacgccgccg uccucaacaa caccgucacc      420

gcccagaucg gcaucgucgc cgucguccgc ggcucccucu ucuucuuccc ccucccccuc      480

cucaucaagc gccucgccuu cugccacucc aacguccucu cccacuccua cugcguccac      540

caggacguca ugaagcucgc cuacgccgac acccucccca acgucgucua cggccucacc      600

gccauccucc ucgucauggg cgucgacguc auguucaucu cccucuccua cuuccucauc      660

auccgcaccg uccuccagcu ccccuccaag uccgagcgcg ccaaggccuu cggcaccugc      720

gucucccaca ucggcgucgu ccucgccuuc uacguccccc ucaucggccu cuccgucguc      780

caccgcuucg gcaacucccu ccaccccauc guccgcgucg ucaugggcga caucuaccuc      840

cuccuccccc ccgucaucaa ccccaucauc uacggcgcca agaccaagca gauccgcacc      900

cgcguccucg ccauguucaa gaucuccugc gacaaggacc uccaggccgu cggcggcaag      960

uga                                                                    963


<210>  3258
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSGR__Homo_sapiens__AAG40776

<400>  3258
augagcuccu gcaacuucac ccacgccaca uuugugcuga ucggcauucc cgggcucgag       60

aaggcucauu ucugggucgg auuuccucuu cugucuaugu acguuguggc aauguucggu      120

aauuguauag uaguguuuau cgucagaacu gaaaggucau ugcacgcccc aauguauuua      180

uuccugugca ugcuagcggc uauugaccuc gcccugagua cgagcaccau gccgaaaauc      240

cuugcacugu uuugguucga uucccgggag auuucuuuug aagccuguuu gacacagaug      300

uucuuuaucc augcucucuc ggcaauagag ucaacuaucc ugcuggccau ggcuuucgac      360

cgcuacgugg ccauuugcca cccccuccga caugcggcag uuuuaaacaa uaccgugaca      420

gcccaaaucg gcauugucgc ugugguacgu gggagccugu uuuucuuccc ucuuccauug      480

cugaucaaga gacuagccuu uugucacagu aacguucucu cccacucuua uugcgugcau      540

caggauguca ugaaacuggc auacgcugac acccuuccca auguggugua uggacugacu      600

gccauauugc ucgucauggg cguugaugug auguucauua gccuguccua cuuuuuaauc      660

auuaggacag uacugcagcu cccuucaaag agugaacggg cgaaagccuu cgguaccugu      720

gugagccaca ucggggucgu gcuugcauuu uauguuccac ugaucggauu gucugugguc      780

caucgcuucg gcaacucccu acaccccauu gugagaguag uuaugggcga cauauaccug      840

cuccugccuc cagugaucaa uccgauuauc uacggggcua agacgaagca gauaaggacu      900

cggguccuug ccauguuuaa aauuucaugc gauaaggacc ugcaagcugu gggagguaaa      960

uga                                                                    963


<210>  3259
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSGR__Homo_sapiens__AAG40776

<400>  3259
augagcagcu gcaacuucac ccacgccacc uucgugcuga ucggcauccc cggccuggag       60

aaggcccacu ucuggguggg cuucccccug cugagcaugu acgugguggc cauguucggc      120

aacugcaucg ugguguucau cgugagaacc gagagaagcc ugcacgcccc cauguaccug      180

uuccugugca ugcuggccgc caucgaccug gcccugagca ccagcaccau gcccaagauc      240

cuggcccugu ucugguucga cagcagagag aucagcuucg aggccugccu gacccagaug      300

uucuucaucc acgcccugag cgccaucgag agcaccaucc ugcuggccau ggccuucgac      360

agauacgugg ccaucugcca cccccugaga cacgccgccg ugcugaacaa caccgugacc      420

gcccagaucg gcaucguggc cguggugaga ggcagccugu ucuucuuccc ccugccccug      480

cugaucaaga gacuggccuu cugccacagc aacgugcuga gccacagcua cugcgugcac      540

caggacguga ugaagcuggc cuacgccgac acccugccca acguggugua cggccugacc      600

gccauccugc uggugauggg cguggacgug auguucauca gccugagcua cuuccugauc      660

aucagaaccg ugcugcagcu gcccagcaag agcgagagag ccaaggccuu cggcaccugc      720

gugagccaca ucggcguggu gcuggccuuc uacgugcccc ugaucggccu gagcguggug      780

cacagauucg gcaacagccu gcaccccauc gugagagugg ugaugggcga caucuaccug      840

cugcugcccc ccgugaucaa ccccaucauc uacggcgcca agaccaagca gaucagaacc      900

agagugcugg ccauguucaa gaucagcugc gacaaggacc ugcaggccgu gggcggcaag      960

uga                                                                    963


<210>  3260
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSGR__Homo_sapiens__AAG40776

<400>  3260
augagcuccu gcaacuucac ccacgccaca uuugugcuga ucggcauucc cgggcucgag       60

aaggcucauu ucuggguggg auuuccucug cuuucuaugu acguuguggc cauguucggc      120

aauuguaucg uggucuuuau ugugagaacg gaacggagcc ugcacgcgcc gauguaucuc      180

uuccugugca ugcuugcugc caucgaccug gcccucucca ccucuacaau gcccaaaauu      240

cuggcucugu uuugguucga uagccgcgag aucuccuuug aagccugucu cacccagaug      300

uucuuuaucc augcucuguc ugccauugag agcacaaucc uucuggcgau ggccuucgac      360

agauacguug cuauuugcca cccucuccgg caugccgcug ugcugaacaa uaccgucaca      420

gcccaaaucg ggauuguggc gguugugcgc ggaucccugu uuuucuuccc ccuuccucuc      480

cugaucaaga gacuggccuu uugucacagc aacguccucu cucacuccua uugcgugcau      540

caggauguga ugaaacuggc uuacgccgac acccuuccca augucguuua uggccugacg      600

gcuauucucc uggugauggg gguggauguc auguucauca gccuuucuua cuuucugauc      660

auucggaccg ugcuccagcu gccuuccaag agcgaacgcg ccaaagccuu cggaacaugu      720

guuucucaca ucggcguggu ccuggcuuuu uaugugccgc ucauuggccu guccguugug      780

cauagauucg ggaacagccu ucaccccauc guccgggugg ucaugggaga cauuuaccug      840

cuccugccuc ccgugaucaa uccuaucauu uacggcgcga agaccaagca gauccgcaca      900

agaguucuug ccauguuuaa aauuuccugc gauaaggacc ugcaagcugu cgggggaaaa      960

uga                                                                    963


<210>  3261
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PSM__Homo_sapiens__Q04609

<400>  3261

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  3262
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PSM__Homo_sapiens__AAA60209

<400>  3262
auguggaauc uccuucacga aaccgacucg gcuguggcca ccgcgcgccg cccgcgcugg       60

cugugcgcug gggcgcuggu gcuggcgggu ggcuucuuuc uccucggcuu ccucuucggg      120

ugguuuauaa aauccuccaa ugaagcuacu aacauuacuc caaagcauaa uaugaaagca      180

uuuuuggaug aauugaaagc ugagaacauc aagaaguucu uauauaauuu uacacagaua      240

ccacauuuag caggaacaga acaaaacuuu cagcuugcaa agcaaauuca aucccagugg      300

aaagaauuug gccuggauuc uguugagcua gcacauuaug auguccuguu guccuaccca      360

aauaagacuc aucccaacua caucucaaua auuaaugaag auggaaauga gauuuucaac      420

acaucauuau uugaaccacc uccuccagga uaugaaaaug uuucggauau uguaccaccu      480

uucagugcuu ucucuccuca aggaaugcca gagggcgauc uaguguaugu uaacuaugca      540

cgaacugaag acuucuuuaa auuggaacgg gacaugaaaa ucaauugcuc ugggaaaauu      600

guaauugcca gauaugggaa aguuuucaga ggaaauaagg uuaaaaaugc ccagcuggca      660

ggggccaaag gagucauucu cuacuccgac ccugcugacu acuuugcucc uggggugaag      720

uccuauccag augguuggaa ucuuccugga gguggugucc agcguggaaa uauccuaaau      780

cugaauggug caggagaccc ucucacacca gguuacccag caaaugaaua ugcuuauagg      840

cguggaauug cagaggcugu uggucuucca aguauuccug uucauccaau uggauacuau      900

gaugcacaga agcuccuaga aaaaaugggu ggcucagcac caccagauag cagcuggaga      960

ggaagucuca aagugcccua caauguugga ccuggcuuua cuggaaacuu uucuacacaa     1020

aaagucaaga ugcacaucca cucuaccaau gaagugacaa gaauuuacaa ugugauaggu     1080

acucucagag gagcagugga accagacaga uaugucauuc ugggagguca ccgggacuca     1140

uggguguuug gugguauuga cccucagagu ggagcagcug uuguucauga aauugugagg     1200

agcuuuggaa cacugaaaaa ggaagggugg agaccuagaa gaacaauuuu guuugcaagc     1260

ugggaugcag aagaauuugg ucuucuuggu ucuacugagu gggcagagga gaauucaaga     1320

cuccuucaag agcguggcgu ggcuuauauu aaugcugacu caucuauaga aggaaacuac     1380

acucugagag uugauuguac accgcugaug uacagcuugg uacacaaccu aacaaaagag     1440

cugaaaagcc cugaugaagg cuuugaaggc aaaucucuuu augaaaguug gacuaaaaaa     1500

aguccuuccc cagaguucag uggcaugccc aggauaagca aauugggauc uggaaaugau     1560

uuugaggugu ucuuccaacg acuuggaauu gcuucaggca gagcacggua uacuaaaaau     1620

ugggaaacaa acaaauucag cggcuaucca cuguaucaca gugucuauga aacauaugag     1680

uugguggaaa aguuuuauga uccaauguuu aaauaucacc ucacuguggc ccagguucga     1740

ggagggaugg uguuugagcu agccaauucc auagugcucc cuuuugauug ucgagauuau     1800

gcuguaguuu uaagaaagua ugcugacaaa aucuacagua uuucuaugaa acauccacag     1860

gaaaugaaga cauacagugu aucauuugau ucacuuuuuu cugcaguaaa gaauuuuaca     1920

gaaauugcuu ccaaguucag ugagagacuc caggacuuug acaaaagcaa cccaauagua     1980

uuaagaauga ugaaugauca acucauguuu cuggaaagag cauuuauuga uccauuaggg     2040

uuaccagaca ggccuuuuua uaggcauguc aucuaugcuc caagcagcca caacaaguau     2100

gcaggggagu cauucccagg aauuuaugau gcucuguuug auauugaaag caaaguggac     2160

ccuuccaagg ccuggggaga agugaagaga cagauuuaug uugcagccuu cacagugcag     2220

gcagcugcag agacuuugag ugaaguagcc uaa                                  2253


<210>  3263
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PSM__Homo_sapiens__AAA60209

<400>  3263
auguggaacc ugcuccacga gaccgacagc gccguggcca ccgcgcgccg gccccgcugg       60

cugugcgccg gggcccuggu ccucgccggg ggcuucuucc ugcugggguu ccucuucggc      120

ugguucauca aguccagcaa cgaggccacg aacaucaccc cgaagcacaa caugaaggcg      180

uuccuggacg agcugaaggc cgagaacauc aagaaguucc ucuacaacuu cacccagauc      240

ccccaccugg ccgggaccga gcagaacuuc cagcuggcca agcagaucca gucccagugg      300

aaggaguucg gccucgacag cguggagcug gcgcacuacg acgugcugcu cuccuacccc      360

aacaagacgc accccaacua caucagcauc aucaacgagg acggcaacga gaucuucaac      420

accucccugu ucgagccgcc cccgcccggg uacgagaacg ucagcgacau cgugccgccc      480

uucuccgccu ucagccccca gggcaugccc gagggggacc ugguguacgu caacuacgcc      540

cggaccgagg acuucuucaa gcucgagcgc gacaugaaga ucaacugcuc cggcaagauc      600

gugaucgccc gguacgggaa gguguuccgc ggcaacaagg ucaagaacgc ccagcuggcg      660

ggcgccaagg gggugauccu guacagcgac cccgccgacu acuucgcccc cggcgugaag      720

uccuaccccg acggguggaa ccuccccggc ggcggggucc agcggggcaa cauccugaac      780

cugaacgggg ccggcgaccc gcucaccccc ggguaccccg cgaacgagua cgccuaccgc      840

cggggcaucg ccgaggccgu gggccugccc agcaucccgg ugcaccccau cggguacuac      900

gacgcccaga agcugcucga gaagaugggc ggguccgcgc cgcccgacag cuccuggcgc      960

ggcagccuga agguccccua caacgugggg cccggcuuca cgggcaacuu cuccacccag     1020

aaggugaaga ugcacaucca cagcaccaac gaggucaccc ggaucuacaa cgugaucggg     1080

acgcugcgcg gcgccgugga gcccgaccgg uacgucaucc ucgggggcca ccgcgacagc     1140

uggguguucg ggggcaucga cccccagucc ggcgccgccg ugguccacga gaucgugcgg     1200

agcuucggga cccugaagaa ggagggcugg cgcccgcggc gcaccauccu guucgccucc     1260

ugggacgcgg aggaguucgg gcuccugggc agcaccgagu gggccgagga gaacucccgg     1320

cugcuccagg agcgcggcgu cgccuacauc aacgccgaca gcuccaucga ggggaacuac     1380

acgcugcggg uggacugcac gccccugaug uacagccucg ugcacaaccu gaccaaggag     1440

cugaaguccc ccgacgaggg cuucgagggc aagagccucu acgaguccug gaccaagaag     1500

uccccgagcc ccgaguucag cgggaugccc cgcaucucca agcuggggag cggcaacgac     1560

uucgaggucu ucuuccagcg ccugggcauc gcguccgggc gggcccgcua caccaagaac     1620

ugggagacca acaaguucag cggcuacccc cucuaccacu ccguguacga gaccuacgag     1680

cugguggaga aguucuacga cccgauguuc aaguaccacc ugaccgucgc ccaggugcgc     1740

gggggcaugg uguucgagcu cgccaacagc aucguccugc ccuucgacug ccgggacuac     1800

gccguggugc ugcggaagua cgcggacaag aucuacagca ucuccaugaa gcacccccag     1860

gagaugaaga cguacagcgu cuccuucgac agccuguucu ccgccgugaa gaacuucacc     1920

gagaucgcca gcaaguucuc cgagcgccuc caggacuucg acaagagcaa ccccaucgug     1980

cugcggauga ugaacgacca gcugauguuc cucgagcgcg ccuucaucga cccgcugggg     2040

cugcccgacc ggcccuucua ccgccacguc aucuacgccc ccuccagcca caacaaguac     2100

gcgggcgagu ccuucccggg caucuacgac gcccucuucg acaucgagag caagguggac     2160

cccuccaagg ccuggggcga ggugaagcgg cagaucuacg ucgccgccuu caccgugcag     2220

gcggccgccg agacccugag cgagguggcc uga                                  2253


<210>  3264
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PSM__Homo_sapiens__AAA60209

<400>  3264
auguggaacc uccuccacga gaccgacucc gccgucgcca ccgcccgccg cccccgcugg       60

cucugcgccg gcgcccucgu ccucgccggc ggcuucuucc uccucggcuu ccucuucggc      120

ugguucauca aguccuccaa cgaggccacc aacaucaccc ccaagcacaa caugaaggcc      180

uuccucgacg agcucaaggc cgagaacauc aagaaguucc ucuacaacuu cacccagauc      240

ccccaccucg ccggcaccga gcagaacuuc cagcucgcca agcagaucca gucccagugg      300

aaggaguucg gccucgacuc cgucgagcuc gcccacuacg acguccuccu cuccuacccc      360

aacaagaccc accccaacua caucuccauc aucaacgagg acggcaacga gaucuucaac      420

accucccucu ucgagccccc cccccccggc uacgagaacg ucuccgacau cguccccccc      480

uucuccgccu ucucccccca gggcaugccc gagggcgacc ucgucuacgu caacuacgcc      540

cgcaccgagg acuucuucaa gcucgagcgc gacaugaaga ucaacugcuc cggcaagauc      600

gucaucgccc gcuacggcaa ggucuuccgc ggcaacaagg ucaagaacgc ccagcucgcc      660

ggcgccaagg gcgucauccu cuacuccgac cccgccgacu acuucgcccc cggcgucaag      720

uccuaccccg acggcuggaa ccuccccggc ggcggcgucc agcgcggcaa cauccucaac      780

cucaacggcg ccggcgaccc ccucaccccc ggcuaccccg ccaacgagua cgccuaccgc      840

cgcggcaucg ccgaggccgu cggccucccc uccauccccg uccaccccau cggcuacuac      900

gacgcccaga agcuccucga gaagaugggc ggcuccgccc cccccgacuc cuccuggcgc      960

ggcucccuca agguccccua caacgucggc cccggcuuca ccggcaacuu cuccacccag     1020

aaggucaaga ugcacaucca cuccaccaac gaggucaccc gcaucuacaa cgucaucggc     1080

acccuccgcg gcgccgucga gcccgaccgc uacgucaucc ucggcggcca ccgcgacucc     1140

ugggucuucg gcggcaucga cccccagucc ggcgccgccg ucguccacga gaucguccgc     1200

uccuucggca cccucaagaa ggagggcugg cgcccccgcc gcaccauccu cuucgccucc     1260

ugggacgccg aggaguucgg ccuccucggc uccaccgagu gggccgagga gaacucccgc     1320

cuccuccagg agcgcggcgu cgccuacauc aacgccgacu ccuccaucga gggcaacuac     1380

acccuccgcg ucgacugcac cccccucaug uacucccucg uccacaaccu caccaaggag     1440

cucaaguccc ccgacgaggg cuucgagggc aagucccucu acgaguccug gaccaagaag     1500

ucccccuccc ccgaguucuc cggcaugccc cgcaucucca agcucggcuc cggcaacgac     1560

uucgaggucu ucuuccagcg ccucggcauc gccuccggcc gcgcccgcua caccaagaac     1620

ugggagacca acaaguucuc cggcuacccc cucuaccacu ccgucuacga gaccuacgag     1680

cucgucgaga aguucuacga ccccauguuc aaguaccacc ucaccgucgc ccagguccgc     1740

ggcggcaugg ucuucgagcu cgccaacucc aucguccucc ccuucgacug ccgcgacuac     1800

gccgucgucc uccgcaagua cgccgacaag aucuacucca ucuccaugaa gcacccccag     1860

gagaugaaga ccuacuccgu cuccuucgac ucccucuucu ccgccgucaa gaacuucacc     1920

gagaucgccu ccaaguucuc cgagcgccuc caggacuucg acaaguccaa ccccaucguc     1980

cuccgcauga ugaacgacca gcucauguuc cucgagcgcg ccuucaucga cccccucggc     2040

cuccccgacc gccccuucua ccgccacguc aucuacgccc ccuccuccca caacaaguac     2100

gccggcgagu ccuuccccgg caucuacgac gcccucuucg acaucgaguc caaggucgac     2160

cccuccaagg ccuggggcga ggucaagcgc cagaucuacg ucgccgccuu caccguccag     2220

gccgccgccg agacccucuc cgaggucgcc uga                                  2253


<210>  3265
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PSM__Homo_sapiens__AAA60209

<400>  3265
auguggaacc ugcuccacga gaccgacagc gccguggcua cagcaagaag gccccggugg       60

cuuugcgccg gcgcgcuggu cuuggcuggg ggauucuuuu uacuggguuu ccuauuuggc      120

ugguucauca aguccucuaa ugaagccacu aacauuacgc cuaaacauaa uaugaaggca      180

uuucucgaug agcugaaagc cgaaaacaua aagaaauucc uuuacaauuu uacccagauc      240

ccacaccugg cugggacaga gcaaaacuuc caguuggcaa agcagauuca gucacaaugg      300

aaggaauuug gacucgacag uguugagcug gcccauuaug augugcugcu cagcuacccg      360

aauaaaacuc accccaacua uaucuccauu aucaaugagg acggcaacga aauauucaau      420

accucuuuau uugagccucc acccccuggu uacgaaaacg uaucggauau cgugccaccc      480

uucucagcuu uuagcccuca ggggaugcca gagggagacc uggucuaugu gaauuacgcc      540

cgcacagagg auuucuucaa gcuagaacga gacaugaaaa uuaacuguag uggcaagauc      600

guuauugcgc guuauggcaa aguguuuaga gggaauaagg ucaagaacgc acaguuggcc      660

ggagcuaaag gugugauccu guacuccgau ccggccgacu acuucgcacc cggcguaaag      720

ucuuauccug auggguggaa ccuaccagga ggcgguguuc agagggggaa uauacucaac      780

cugaauggag cuggcgaccc ccuuaccccu ggcuacccag ccaacgagua ugcguaccgg      840

cgcgggauug ccgaagcagu gggacugccc agcaucccgg uccauccuau ugguuauuac      900

gaugcucaaa aauugcucga gaagaugggc ggguccgcuc ccccagacuc aaguuggaga      960

ggaagccuga aagugccuua uaaugugggc cccgguuuua cugggaacuu cucuacacag     1020

aaggucaaaa ugcacaucca cuccaccaau gaaguuacga ggaucuacaa cgugauuggc     1080

acuuuacggg gagccguaga gccagaccgc uacgugauac ugggcgggca ucgagauuca     1140

ugggucuuug gagguaucga cccccagagc ggcgccgcag ugguucacga gauugugaga     1200

aguuucggga cccucaagaa ggaaggaugg aggccucggc guacaauccu uuuugccucu     1260

ugggaugcug aggaguucgg ccuguugggu uccacugaau gggcggaaga gaauagccgc     1320

cuacugcagg agagaggggu cgcauauaua aacgccgacu cgucuauuga aggcaauuac     1380

acccucaggg uggauugcac accacugaug uauucccuug uacauaaccu gaccaaagag     1440

uugaagucac cggacgaagg auuugagggc aaaagucucu acgaaagcug gacgaagaaa     1500

ucccccucuc cugaguucag cgggaugcca cggaucucaa agcugggaag ugguaaugau     1560

uuugagguuu ucuuucaacg auuaggcauc gcuuccgggc gcgccagaua uacuaagaac     1620

ugggaaacaa auaaauucag cggauacccc cuguaucacu cuguguacga gaccuacgaa     1680

cuugucgaga aguucuauga cccuauguuu aaauaccacc ucacuguggc acaggucagg     1740

ggcgguaugg uguucgagcu ggccaacuca auuguucuuc cauuugauug ucgggacuau     1800

gcugugguau ugcgcaagua cgccgauaaa aucuauagua uuagcaugaa gcauccccag     1860

gaaaugaaga cauacuccgu cucuuucgac ucgcuguuua gcgcagugaa aaacuucacc     1920

gagauagcgu ccaaguuuuc agaaagacuc caagacuucg auaaaaguaa uccgaucguu     1980

cugaggauga ugaacgacca gcuuauguuu cuggagcgug cuuucauuga uccuuugggg     2040

cucccagacc ggcccuuuua ucgacacgug aucuacgccc cuucuagcca uaauaaguac     2100

gcaggcgaau ccuuccccgg aaucuaugau gcccuguuug acauugaguc aaaagucgau     2160

ccaagcaagg cuuggggcga ggugaagaga cagauauacg uagccgcauu cacggugcag     2220

gcugccgcgg aaaccuuauc ugagguugcc uga                                  2253


<210>  3266
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PSM__Homo_sapiens__AAA60209

<400>  3266
auguggaacc ugcugcacga gaccgacagc gccguggcca ccgccagaag acccagaugg       60

cugugcgccg gcgcccuggu gcuggccggc ggcuucuucc ugcugggcuu ccuguucggc      120

ugguucauca agagcagcaa cgaggccacc aacaucaccc ccaagcacaa caugaaggcc      180

uuccuggacg agcugaaggc cgagaacauc aagaaguucc uguacaacuu cacccagauc      240

ccccaccugg ccggcaccga gcagaacuuc cagcuggcca agcagaucca gagccagugg      300

aaggaguucg gccuggacag cguggagcug gcccacuacg acgugcugcu gagcuacccc      360

aacaagaccc accccaacua caucagcauc aucaacgagg acggcaacga gaucuucaac      420

accagccugu ucgagccccc cccccccggc uacgagaacg ugagcgacau cgugcccccc      480

uucagcgccu ucagccccca gggcaugccc gagggcgacc ugguguacgu gaacuacgcc      540

agaaccgagg acuucuucaa gcuggagaga gacaugaaga ucaacugcag cggcaagauc      600

gugaucgcca gauacggcaa gguguucaga ggcaacaagg ugaagaacgc ccagcuggcc      660

ggcgccaagg gcgugauccu guacagcgac cccgccgacu acuucgcccc cggcgugaag      720

agcuaccccg acggcuggaa ccugcccggc ggcggcgugc agagaggcaa cauccugaac      780

cugaacggcg ccggcgaccc ccugaccccc ggcuaccccg ccaacgagua cgccuacaga      840

agaggcaucg ccgaggccgu gggccugccc agcauccccg ugcaccccau cggcuacuac      900

gacgcccaga agcugcugga gaagaugggc ggcagcgccc cccccgacag cagcuggaga      960

ggcagccuga aggugcccua caacgugggc cccggcuuca ccggcaacuu cagcacccag     1020

aaggugaaga ugcacaucca cagcaccaac gaggugacca gaaucuacaa cgugaucggc     1080

acccugagag gcgccgugga gcccgacaga uacgugaucc ugggcggcca cagagacagc     1140

uggguguucg gcggcaucga cccccagagc ggcgccgccg uggugcacga gaucgugaga     1200

agcuucggca cccugaagaa ggagggcugg agacccagaa gaaccauccu guucgccagc     1260

ugggacgccg aggaguucgg ccugcugggc agcaccgagu gggccgagga gaacagcaga     1320

cugcugcagg agagaggcgu ggccuacauc aacgccgaca gcagcaucga gggcaacuac     1380

acccugagag uggacugcac cccccugaug uacagccugg ugcacaaccu gaccaaggag     1440

cugaagagcc ccgacgaggg cuucgagggc aagagccugu acgagagcug gaccaagaag     1500

agccccagcc ccgaguucag cggcaugccc agaaucagca agcugggcag cggcaacgac     1560

uucgaggugu ucuuccagag acugggcauc gccagcggca gagccagaua caccaagaac     1620

ugggagacca acaaguucag cggcuacccc cuguaccaca gcguguacga gaccuacgag     1680

cugguggaga aguucuacga ccccauguuc aaguaccacc ugaccguggc ccaggugaga     1740

ggcggcaugg uguucgagcu ggccaacagc aucgugcugc ccuucgacug cagagacuac     1800

gccguggugc ugagaaagua cgccgacaag aucuacagca ucagcaugaa gcacccccag     1860

gagaugaaga ccuacagcgu gagcuucgac agccuguuca gcgccgugaa gaacuucacc     1920

gagaucgcca gcaaguucag cgagagacug caggacuucg acaagagcaa ccccaucgug     1980

cugagaauga ugaacgacca gcugauguuc cuggagagag ccuucaucga cccccugggc     2040

cugcccgaca gacccuucua cagacacgug aucuacgccc ccagcagcca caacaaguac     2100

gccggcgaga gcuuccccgg caucuacgac gcccuguucg acaucgagag caagguggac     2160

cccagcaagg ccuggggcga ggugaagaga cagaucuacg uggccgccuu caccgugcag     2220

gccgccgccg agacccugag cgagguggcc uga                                  2253


<210>  3267
<211>  2253
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PSM__Homo_sapiens__AAA60209

<400>  3267
auguggaacc ugcuccacga gaccgacagc gccguggcua cagccagacg gccccgcugg       60

cugugcgcgg gcgcucuugu ccuggccggg ggauucuuuc uccugggcuu ccuuuuuggg      120

ugguucauca aguccucuaa ugaagccacg aacauuaccc cuaaacauaa uaugaaggcu      180

uuucuggaug agcucaaagc cgaaaacauc aagaaauucc uguacaauuu uacacagauu      240

ccgcaccugg cuggaaccga gcaaaacuuc cagcucgcca agcagaucca gagccaaugg      300

aaggaauuug gccuggacuc cguugagcuu gcgcauuaug augugcugcu cucuuacccc      360

aauaaaacac acccuaacua uauuagcauc aucaaugagg acgggaacga aauuuucaau      420

accucccugu uugagccccc ucccccugga uacgaaaacg ugucugauau cgucccgccc      480

uucagcgccu uuuccccuca gggcaugccc gagggcgacc uuguguaugu uaauuacgcu      540

agaacagagg auuucuucaa gcuggaacgg gacaugaaaa uuaacuguag cgggaagauc      600

gugauugccc gcuauggaaa agucuuuaga ggcaauaagg ugaagaacgc ucagcucgcc      660

ggggcgaaag gaguuauccu guacucugau ccugccgacu acuucgcucc cggcgugaag      720

uccuauccgg auggguggaa ccugccugga ggcggcgucc agcgggggaa uauucucaac      780

cugaauggag ccggcgaccc ccuuaccccu ggguaccccg cuaacgagua ugccuaccgc      840

agaggaaucg ccgaagcugu gggccugccc agcaucccug ugcauccgau uggguauuac      900

gaugcgcaaa aacuccugga gaagauggga ggcucugcuc ccccugacuc cagcuggcgg      960

ggcucucuua aaguccccua uaauguuggg ccuggauuua cgggcaacuu cuccacccag     1020

aaggugaaaa ugcacaucca cagcacaaau gaagugaccc gcauuuacaa cgucaucggg     1080

acacugagag gagccgugga gcccgaccgg uacguuauuc ucggcgggca ucgcgauucc     1140

uggguguuug gcggaaucga cccgcagucu ggcgccgccg ucgugcacga gaucguucgg     1200

agcuucggga cccugaagaa ggaaggaugg agaccucgca gaacgauucu guuugcuucc     1260

ugggaugccg aggaguucgg ccuccugggg agcacagagu gggcggaaga aaauucucgg     1320

cuucugcagg agagaggagu ggcuuauauc aacgccgacu ccagcauuga aggcaauuac     1380

acccuccgcg ucgauugcac accccugaug uauucucuug ugcauaaccu gaccaaagag     1440

cucaagagcc cugacgaagg guuugagggc aaaucccugu acgaaucuug gaccaagaaa     1500

agccccuccc cugaguucag cggaaugccc cggaucucua agcugggcuc cgggaaugau     1560

uuugaggucu ucuuucaaag acucggaauu gccagcggcc gcgcucggua uacaaagaac     1620

ugggaaacga auaaauucuc uggguacccg cuguaucacu ccguguacga gaccuacgaa     1680

cuuguugaga aguucuauga cccuauguuu aaauaccacc ugacaguggc ccaggucaga     1740

ggaggcaugg uguucgagcu cgcuaacagc aucguucugc ccuuugauug ucgcgacuau     1800

gccguggucc ugcggaagua cgcggauaaa aucuauucca uuucuaugaa gcauccccag     1860

gaaaugaaga ccuacagcgu guccuucgac ucucuuuuua gcgccgugaa aaacuucaca     1920

gagaucgcuu ccaaguuuag cgaaagacuc caagacuucg auaaaucuaa uccuauuguu     1980

cugcgcauga ugaacgacca gcugauguuu cucgagcggg ccuucaucga uccgcugggg     2040

cuucccgaca gaccuuuuua ucgccacguc auuuacgcuc ccuccagcca uaauaaguac     2100

gccggcgaau cuuucccugg aaucuaugau gcgcuguuug acauugaguc caaaguggau     2160

cccagcaagg ccuggggcga ggugaagcgg cagaucuacg ucgcugccuu caccgugcag     2220

gcugccgccg aaacgcucuc ugagguugcu uga                                  2253


<210>  3268
<211>  1306
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PTPRC__Homo_sapiens__NP_002829

<400>  3268

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
        995                 1000                1005            


Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
    1010                1015                1020                


Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
1025                1030                1035                1040


Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys 
                1045                1050                1055    


Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys 
            1060                1065                1070        


Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val 
        1075                1080                1085            


Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe 
    1090                1095                1100                


Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr 
1105                1110                1115                1120


Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu 
                1125                1130                1135    


Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn 
            1140                1145                1150        


Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His 
        1155                1160                1165            


Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn 
    1170                1175                1180                


Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val 
1185                1190                1195                1200


Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu 
                1205                1210                1215    


Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln 
            1220                1225                1230        


Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe 
        1235                1240                1245            


Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro 
    1250                1255                1260                


Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly 
1265                1270                1275                1280


Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly 
                1285                1290                1295    


Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser 
            1300                1305    


<210>  3269
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PTPRC__Homo_sapiens__CCDS1397.2

<400>  3269
augaccaugu auuuguggcu uaaacucuug gcauuuggcu uugccuuucu ggacacagaa       60

guauuuguga cagggcaaag cccaacaccu ucccccacug gauugacuac agcaaagaug      120

cccaguguuc cacuuucaag ugaccccuua ccuacucaca ccacugcauu cucacccgca      180

agcaccuuug aaagagaaaa ugacuucuca gagaccacaa cuucucuuag uccagacaau      240

acuuccaccc aaguaucccc ggacucuuug gauaaugcua gugcuuuuaa uaccacaggu      300

guuucaucag uacagacgcc ucaccuuccc acgcacgcag acucgcagac gcccucugcu      360

ggaacugaca cgcagacauu cagcggcucc gccgccaaug caaaacucaa cccuacccca      420

ggcagcaaug cuaucucaga ugucccagga gagaggagua cagccagcac cuuuccuaca      480

gacccaguuu ccccauugac aaccacccuc agccuugcac accacagcuc ugcugccuua      540

ccugcacgca ccuccaacac caccaucaca gcgaacaccu cagaugccua ccuuaaugcc      600

ucugaaacaa ccacucugag cccuucugga agcgcuguca uuucaaccac aacaauagcu      660

acuacuccau cuaagccaac augugaugaa aaauaugcaa acaucacugu ggauuacuua      720

uauaacaagg aaacuaaauu auuuacagca aagcuaaaug uuaaugagaa uguggaaugu      780

ggaaacaaua cuugcacaaa caaugaggug cauaaccuua cagaauguaa aaaugcgucu      840

guuuccauau cucauaauuc auguacugcu ccugauaaga cauuaauauu agaugugcca      900

ccagggguug aaaaguuuca guuacaugau uguacacaag uugaaaaagc agauacuacu      960

auuuguuuaa aauggaaaaa uauugaaacc uuuacuugug auacacagaa uauuaccuac     1020

agauuucagu gugguaauau gauauuugau aauaaagaaa uuaaauuaga aaaccuugaa     1080

cccgaacaug aguauaagug ugacucagaa auacucuaua auaaccacaa guuuacuaac     1140

gcaaguaaaa uuauuaaaac agauuuuggg aguccaggag agccucagau uauuuuuugu     1200

agaagugaag cugcacauca aggaguaauu accuggaauc ccccucaaag aucauuucau     1260

aauuuuaccc ucuguuauau aaaagagaca gaaaaagauu gccucaaucu ggauaaaaac     1320

cugaucaaau augauuugca aaauuuaaaa ccuuauacga aauauguuuu aucauuacau     1380

gccuacauca uugcaaaagu gcaacguaau ggaagugcug caauguguca uuucacaacu     1440

aaaagugcuc cuccaagcca ggucuggaac augacugucu ccaugacauc agauaauagu     1500

augcauguca aguguaggcc ucccagggac cguaauggcc cccaugaacg uuaccauuug     1560

gaaguugaag cuggaaauac ucugguuaga aaugagucgc auaagaauug cgauuuccgu     1620

guaaaagauc uucaauauuc aacagacuac acuuuuaagg ccuauuuuca caauggagac     1680

uauccuggag aacccuuuau uuuacaucau ucaacaucuu auaauucuaa ggcacugaua     1740

gcauuucugg cauuucugau uauugugaca ucaauagccc ugcuuguugu ucucuacaaa     1800

aucuaugauc uacauaagaa aagauccugc aauuuagaug aacagcagga gcuuguugaa     1860

agggaugaug aaaaacaacu gaugaaugug gagccaaucc augcagauau uuuguuggaa     1920

acuuauaaga ggaagauugc ugaugaagga agacuuuuuc uggcugaauu ucagagcauc     1980

ccgcgggugu ucagcaaguu uccuauaaag gaagcucgaa agcccuuuaa ccagaauaaa     2040

aaccguuaug uugacauucu uccuuaugau uauaaccgug uugaacucuc ugagauaaac     2100

ggagaugcag ggucaaacua cauaaaugcc agcuauauug augguuucaa agaacccagg     2160

aaauacauug cugcacaagg ucccagggau gaaacuguug augauuucug gaggaugauu     2220

ugggaacaga aagccacagu uauugucaug gucacucgau gugaagaagg aaacaggaac     2280

aagugugcag aauacuggcc gucaauggaa gagggcacuc gggcuuuugg agauguuguu     2340

guaaagauca accagcacaa aagaugucca gauuacauca uucagaaauu gaacauugua     2400

aauaaaaaag aaaaagcaac uggaagagag gugacucaca uucaguucac cagcuggcca     2460

gaccacgggg ugccugagga uccucacuug cuccucaaac ugagaaggag agugaaugcc     2520

uucagcaauu ucuucagugg ucccauugug gugcacugca gugcuggugu ugggcgcaca     2580

ggaaccuaua ucggaauuga ugccaugcua gaaggccugg aagccgagaa caaaguggau     2640

guuuaugguu auguugucaa gcuaaggcga cagagaugcc ugaugguuca aguagaggcc     2700

caguacaucu ugauccauca ggcuuuggug gaauacaauc aguuuggaga aacagaagug     2760

aauuugucug aauuacaucc auaucuacau aacaugaaga aaagggaucc acccagugag     2820

ccgucuccac uagaggcuga auuccagaga cuuccuucau auaggagcug gaggacacag     2880

cacauuggaa aucaagaaga aaauaaaagu aaaaacagga auucuaaugu caucccauau     2940

gacuauaaca gagugccacu uaaacaugag cuggaaauga guaaagagag ugagcaugau     3000

ucagaugaau ccucugauga ugacagugau ucagaggaac caagcaaaua caucaaugca     3060

ucuuuuauaa ugagcuacug gaaaccugaa gugaugauug cugcucaggg accacugaag     3120

gagaccauug gugacuuuug gcagaugauc uuccaaagaa aagucaaagu uauuguuaug     3180

cugacagaac ugaaacaugg agaccaggaa aucugugcuc aguacugggg agaaggaaag     3240

caaacauaug gagauauuga aguugaccug aaagacacag acaaaucuuc aacuuauacc     3300

cuucgugucu uugaacugag acauuccaag aggaaagacu cucgaacugu guaccaguac     3360

caauauacaa acuggagugu ggagcagcuu ccugcagaac ccaaggaauu aaucucuaug     3420

auucaggucg ucaaacaaaa acuuccccag aagaauuccu cugaagggaa caagcaucac     3480

aagaguacac cucuacucau ucacugcagg gauggaucuc agcaaacggg aauauuuugu     3540

gcuuuguuaa aucucuuaga aagugcggaa acagaagagg uaguggauau uuuucaagug     3600

guaaaagcuc uacgcaaagc uaggccaggc augguuucca cauucgagca auaucaauuc     3660

cuauaugacg ucauugccag caccuacccu gcucagaaug gacaaguaaa gaaaaacaac     3720

caucaagaag auaaaauuga auuugauaau gaaguggaca aaguaaagca ggaugcuaau     3780

uguguuaauc cacuuggugc cccagaaaag cucccugaag caaaggaaca ggcugaaggu     3840

ucugaaccca cgaguggcac ugaggggcca gaacauucug ucaauggucc ugcaagucca     3900

gcuuuaaauc aagguucaua g                                               3921


<210>  3270
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PTPRC__Homo_sapiens__CCDS1397.2

<400>  3270
augaccaugu accuguggcu caagcugcug gccuucggcu ucgccuuccu cgacaccgag       60

guguucguca cggggcagag ccccaccccg ucccccaccg gccugaccac ggcgaagaug      120

cccagcgugc cccuguccag cgacccgcuc cccacccaca ccaccgccuu cucccccgcc      180

agcacguucg agcgcgagaa cgacuucucc gagaccacca ccagccuguc ccccgacaac      240

acgagcaccc aggugucccc ggacagccug gacaacgccu ccgccuucaa caccaccggg      300

gucagcuccg ugcagacgcc ccaccucccc acccacgcgg acagccagac ccccuccgcc      360

ggcaccgaca cgcagaccuu cagcgggucc gccgccaacg cgaagcugaa cccgaccccc      420

ggcagcaacg ccaucagcga cgugcccggc gagcggucca ccgccagcac guuccccacc      480

gacccgguca gcccccugac caccacgcuc ucccuggccc accacuccag cgccgcgcug      540

cccgcccgca ccuccaacac caccaucacg gccaacacca gcgacgccua ccucaacgcc      600

uccgagacca ccacgcugag ccccuccggg agcgcgguga ucuccaccac caccaucgcc      660

accacgccga gcaagcccac gugcgacgag aaguacgcca acaucaccgu ggacuaccug      720

uacaacaagg agaccaagcu guucaccgcc aagcugaacg ucaacgagaa cguggagugc      780

ggcaacaaca cgugcaccaa caacgaggug cacaaccuga ccgagugcaa gaacgccucc      840

gucagcaucu cccacaacag cugcaccgcg cccgacaaga cccucauccu ggacgugccc      900

ccgggggugg agaaguucca gcugcacgac ugcacccagg ucgagaaggc cgacaccacg      960

aucugccuca aguggaagaa caucgagacc uucacgugcg acacccagaa caucaccuac     1020

cgguuccagu gcggcaacau gaucuucgac aacaaggaga ucaagcugga gaaccuggag     1080

cccgagcacg aguacaagug cgacuccgag auccucuaca acaaccacaa guucaccaac     1140

gccagcaaga ucaucaagac cgacuucggg agccccggcg agccccagau caucuucugc     1200

cgcuccgagg ccgcccacca gggcgugauc accuggaacc cgccccagcg gagcuuccac     1260

aacuucacgc ugugcuacau caaggagacc gagaaggacu gccugaaccu cgacaagaac     1320

cugaucaagu acgaccugca gaaccucaag cccuacacca aguacgugcu gucccugcac     1380

gcguacauca ucgccaaggu ccagcgcaac gggagcgccg ccaugugcca cuucaccacg     1440

aaguccgcgc cgcccagcca gguguggaac augaccgugu ccaugaccag cgacaacucc     1500

augcacguca agugccggcc gccccgcgac cggaacggcc cccacgagcg cuaccaccuc     1560

gagguggagg ccgggaacac ccuggugcgg aacgagagcc acaagaacug cgacuuccgc     1620

gucaaggacc ugcaguacuc cacggacuac accuucaagg ccuacuucca caacggcgac     1680

uaccccggcg agcccuucau ccuccaccac agcaccuccu acaacagcaa ggcccugauc     1740

gccuuccugg cguuccucau caucgugacc uccaucgccc ugcuggucgu gcucuacaag     1800

aucuacgacc ugcacaagaa gcggagcugc aaccuggacg agcagcagga gcucguggag     1860

cgcgacgacg agaagcagcu gaugaacguc gagcccaucc acgccgacau ccugcuggag     1920

acguacaagc ggaagaucgc cgacgagggg cgccucuucc uggccgaguu ccaguccauc     1980

ccgcgggugu ucagcaaguu ccccaucaag gaggcgcgca agcccuucaa ccagaacaag     2040

aaccgguacg uggacauccu gcccuacgac uacaaccgcg ucgagcucag cgagaucaac     2100

ggcgacgccg gguccaacua caucaacgcc agcuacaucg acggcuucaa ggagccgcgg     2160

aaguacaucg ccgcccaggg gccccgcgac gagaccgugg acgacuucug gcgcaugauc     2220

ugggagcaga aggcgaccgu gaucgucaug gugacccggu gcgaggaggg caaccgcaac     2280

aagugcgccg aguacuggcc cuccauggag gagggcacgc gggccuucgg ggacgugguc     2340

gugaagauca accagcacaa gcgcugcccc gacuacauca uccagaagcu gaacaucgug     2400

aacaagaagg agaaggccac cggccgggag gucacccaca uccaguucac cagcuggccg     2460

gaccacgggg ugcccgagga cccccaccuc cuccugaagc ugcgccggcg cgugaacgcg     2520

uucuccaacu ucuucagcgg ccccaucguc gugcacugcu ccgccggggu gggccggacc     2580

ggcacguaca ucgggaucga cgccaugcuc gagggccugg aggccgagaa caaggucgac     2640

guguacgggu acguggucaa gcugcgccgg cagcgcugcc ucauggucca gguggaggcc     2700

caguacaucc ugauccacca ggcgcuggug gaguacaacc aguucggcga gaccgaggug     2760

aaccucagcg agcugcaccc guaccugcac aacaugaaga agcgggaccc gcccuccgag     2820

cccagccccc ucgaggccga guuccagcgc cugcccuccu accggagcug gcgcacccag     2880

cacaucggga accaggagga gaacaagucc aagaaccgga acagcaacgu gauccccuac     2940

gacuacaacc gcgucccgcu gaagcacgag cucgagaugu ccaaggagag cgagcacgac     3000

uccgacgaga gcuccgacga cgacagcgac agcgaggagc ccuccaagua caucaacgcc     3060

agcuucauca uguccuacug gaagcccgag gugaugaucg ccgcccaggg cccccugaag     3120

gagaccaucg gcgacuucug gcagaugauc uuccagcgga aggugaaggu caucgugaug     3180

cugacggagc ucaagcacgg ggaccaggag aucugcgcgc aguacugggg cgaggggaag     3240

cagaccuacg gcgacaucga gguggaccug aaggacaccg acaagagcuc caccuacacg     3300

cugcgcgucu ucgagcuccg ccacagcaag cggaaggacu cccgcaccgu guaccaguac     3360

caguacacca acuggagcgu ggagcagcug ccggccgagc ccaaggagcu gaucuccaug     3420

auccaggucg ugaagcagaa gcucccccag aagaacagcu ccgagggcaa caagcaccac     3480

aagagcacgc cccugcugau ccacugccgg gacggguccc agcagaccgg caucuucugc     3540

gcccuccuga accugcucga gagcgccgag accgaggagg uggucgacau cuuccaggug     3600

gugaaggccc ugcgcaaggc gcggccgggg auggucucca ccuucgagca guaccaguuc     3660

cuguacgacg ugaucgccag caccuacccc gcccagaacg gccaggugaa gaagaacaac     3720

caccaggagg acaagaucga guucgacaac gaggucgaca aggugaagca ggacgccaac     3780

ugcgugaacc cccucggggc gcccgagaag cugccggagg ccaaggagca ggccgagggc     3840

uccgagccca cgagcggcac cgaggggccc gagcacuccg ucaacggccc cgccagcccg     3900

gcccugaacc aggggagcug a                                               3921


<210>  3271
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PTPRC__Homo_sapiens__CCDS1397.2

<400>  3271
augaccaugu accucuggcu caagcuccuc gccuucggcu ucgccuuccu cgacaccgag       60

gucuucguca ccggccaguc ccccaccccc ucccccaccg gccucaccac cgccaagaug      120

cccuccgucc cccucuccuc cgacccccuc cccacccaca ccaccgccuu cucccccgcc      180

uccaccuucg agcgcgagaa cgacuucucc gagaccacca ccucccucuc ccccgacaac      240

accuccaccc aggucucccc cgacucccuc gacaacgccu ccgccuucaa caccaccggc      300

gucuccuccg uccagacccc ccaccucccc acccacgccg acucccagac ccccuccgcc      360

ggcaccgaca cccagaccuu cuccggcucc gccgccaacg ccaagcucaa ccccaccccc      420

ggcuccaacg ccaucuccga cguccccggc gagcgcucca ccgccuccac cuuccccacc      480

gaccccgucu ccccccucac caccacccuc ucccucgccc accacuccuc cgccgcccuc      540

cccgcccgca ccuccaacac caccaucacc gccaacaccu ccgacgccua ccucaacgcc      600

uccgagacca ccacccucuc ccccuccggc uccgccguca ucuccaccac caccaucgcc      660

accacccccu ccaagcccac cugcgacgag aaguacgcca acaucaccgu cgacuaccuc      720

uacaacaagg agaccaagcu cuucaccgcc aagcucaacg ucaacgagaa cgucgagugc      780

ggcaacaaca ccugcaccaa caacgagguc cacaaccuca ccgagugcaa gaacgccucc      840

gucuccaucu cccacaacuc cugcaccgcc cccgacaaga cccucauccu cgacgucccc      900

cccggcgucg agaaguucca gcuccacgac ugcacccagg ucgagaaggc cgacaccacc      960

aucugccuca aguggaagaa caucgagacc uucaccugcg acacccagaa caucaccuac     1020

cgcuuccagu gcggcaacau gaucuucgac aacaaggaga ucaagcucga gaaccucgag     1080

cccgagcacg aguacaagug cgacuccgag auccucuaca acaaccacaa guucaccaac     1140

gccuccaaga ucaucaagac cgacuucggc ucccccggcg agccccagau caucuucugc     1200

cgcuccgagg ccgcccacca gggcgucauc accuggaacc ccccccagcg cuccuuccac     1260

aacuucaccc ucugcuacau caaggagacc gagaaggacu gccucaaccu cgacaagaac     1320

cucaucaagu acgaccucca gaaccucaag cccuacacca aguacguccu cucccuccac     1380

gccuacauca ucgccaaggu ccagcgcaac ggcuccgccg ccaugugcca cuucaccacc     1440

aaguccgccc cccccuccca ggucuggaac augaccgucu ccaugaccuc cgacaacucc     1500

augcacguca agugccgccc cccccgcgac cgcaacggcc cccacgagcg cuaccaccuc     1560

gaggucgagg ccggcaacac ccucguccgc aacgaguccc acaagaacug cgacuuccgc     1620

gucaaggacc uccaguacuc caccgacuac accuucaagg ccuacuucca caacggcgac     1680

uaccccggcg agcccuucau ccuccaccac uccaccuccu acaacuccaa ggcccucauc     1740

gccuuccucg ccuuccucau caucgucacc uccaucgccc uccucgucgu ccucuacaag     1800

aucuacgacc uccacaagaa gcgcuccugc aaccucgacg agcagcagga gcucgucgag     1860

cgcgacgacg agaagcagcu caugaacguc gagcccaucc acgccgacau ccuccucgag     1920

accuacaagc gcaagaucgc cgacgagggc cgccucuucc ucgccgaguu ccaguccauc     1980

ccccgcgucu ucuccaaguu ccccaucaag gaggcccgca agcccuucaa ccagaacaag     2040

aaccgcuacg ucgacauccu ccccuacgac uacaaccgcg ucgagcucuc cgagaucaac     2100

ggcgacgccg gcuccaacua caucaacgcc uccuacaucg acggcuucaa ggagccccgc     2160

aaguacaucg ccgcccaggg cccccgcgac gagaccgucg acgacuucug gcgcaugauc     2220

ugggagcaga aggccaccgu caucgucaug gucacccgcu gcgaggaggg caaccgcaac     2280

aagugcgccg aguacuggcc cuccauggag gagggcaccc gcgccuucgg cgacgucguc     2340

gucaagauca accagcacaa gcgcugcccc gacuacauca uccagaagcu caacaucguc     2400

aacaagaagg agaaggccac cggccgcgag gucacccaca uccaguucac cuccuggccc     2460

gaccacggcg uccccgagga cccccaccuc cuccucaagc uccgccgccg cgucaacgcc     2520

uucuccaacu ucuucuccgg ccccaucguc guccacugcu ccgccggcgu cggccgcacc     2580

ggcaccuaca ucggcaucga cgccaugcuc gagggccucg aggccgagaa caaggucgac     2640

gucuacggcu acgucgucaa gcuccgccgc cagcgcugcc ucauggucca ggucgaggcc     2700

caguacaucc ucauccacca ggcccucguc gaguacaacc aguucggcga gaccgagguc     2760

aaccucuccg agcuccaccc cuaccuccac aacaugaaga agcgcgaccc ccccuccgag     2820

cccucccccc ucgaggccga guuccagcgc cuccccuccu accgcuccug gcgcacccag     2880

cacaucggca accaggagga gaacaagucc aagaaccgca acuccaacgu cauccccuac     2940

gacuacaacc gcgucccccu caagcacgag cucgagaugu ccaaggaguc cgagcacgac     3000

uccgacgagu ccuccgacga cgacuccgac uccgaggagc ccuccaagua caucaacgcc     3060

uccuucauca uguccuacug gaagcccgag gucaugaucg ccgcccaggg cccccucaag     3120

gagaccaucg gcgacuucug gcagaugauc uuccagcgca aggucaaggu caucgucaug     3180

cucaccgagc ucaagcacgg cgaccaggag aucugcgccc aguacugggg cgagggcaag     3240

cagaccuacg gcgacaucga ggucgaccuc aaggacaccg acaaguccuc caccuacacc     3300

cuccgcgucu ucgagcuccg ccacuccaag cgcaaggacu cccgcaccgu cuaccaguac     3360

caguacacca acugguccgu cgagcagcuc cccgccgagc ccaaggagcu caucuccaug     3420

auccaggucg ucaagcagaa gcucccccag aagaacuccu ccgagggcaa caagcaccac     3480

aaguccaccc cccuccucau ccacugccgc gacggcuccc agcagaccgg caucuucugc     3540

gcccuccuca accuccucga guccgccgag accgaggagg ucgucgacau cuuccagguc     3600

gucaaggccc uccgcaaggc ccgccccggc auggucucca ccuucgagca guaccaguuc     3660

cucuacgacg ucaucgccuc caccuacccc gcccagaacg gccaggucaa gaagaacaac     3720

caccaggagg acaagaucga guucgacaac gaggucgaca aggucaagca ggacgccaac     3780

ugcgucaacc cccucggcgc ccccgagaag cuccccgagg ccaaggagca ggccgagggc     3840

uccgagccca ccuccggcac cgagggcccc gagcacuccg ucaacggccc cgccuccccc     3900

gcccucaacc agggcuccug a                                               3921


<210>  3272
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PTPRC__Homo_sapiens__CCDS1397.2

<400>  3272
augaccaugu accuguggcu caagcuccug gccuucggcu uugcuuucuu ggacacagag       60

guguuuguca cugggcagag ccccacgccu uccccaaccg gauuaacaac ugcaaaaaug      120

ccgucuguuc cccugucaag ugauccucua ccaacccaca caaccgccuu cagccccgcg      180

uccacuuuug aaagagagaa cgacuucucu gaaacaacca cgucgcucuc accugauaau      240

acuagcaccc aagugagucc agacucccug gauaacgcuu cugccuuuaa uacaacuggu      300

guaagcuccg ugcagacacc ccaucuuccu acccacgcag acucacagac cccaagugcc      360

ggcacggaua cucagacauu cagcgggucu gcugcaaacg ccaagcugaa uccgaccccc      420

ggauccaacg cuaucucaga cgucccuggc gagaggagca cugccaguac auuuccaacc      480

gaucccgugu cuccuuugac gaccacacuc ucccuggcgc aucacagcuc ggcagcccug      540

ccagcucgga cuucuaauac cacaauuacu gccaacaccu ccgacgcaua ucucaaugcu      600

ucagaaacaa ccacuuuaag ucccagcggu uccgccguua uaucuacgac aaccaucgcg      660

acuaccccga gcaaaccuac augcgaugag aaguacgcca acauuaccgu ggacuaucug      720

uacaauaaag agacuaaacu uuucacagca aaguugaacg ucaaugaaaa cguggagugu      780

gggaauaaca cgugcaccaa caaugaagua cauaaccuga cugaguguaa gaaugcuuca      840

guuaguaucu cccacaacag cugcacagcc cccgauaaga cccuaauucu cgacgugcca      900

ccuggagucg agaaauuuca acugcacgac uguacacagg uggaaaaggc ugauacuacc      960

aucugccuua aauggaagaa uauagagacg uucaccugug acacacagaa caucacuuau     1020

cgcuuucagu gcggcaauau gauuuucgau aacaaggaaa ucaaacugga gaauuuggaa     1080

cccgagcaug aguacaagug ugacucugaa auucucuaua acaaucacaa auucaccaac     1140

gccucaaaga ucauaaaaac agauuuuggc aguccagggg agccccaaau uaucuucugc     1200

cgaagcgaag cagcccauca gggagugauu acuuggaauc cuccacagcg uuccuuucac     1260

aacuucaccc uguguuacau caaggagacg gaaaaagacu gcuuaaaucu ggauaagaac     1320

cucaucaagu acgaccuuca gaaccugaaa ccguauacaa aguacgucuu gucucuacac     1380

gcuuauauua uagcgaaagu ucaaagaaau gguucggcag ccaugugcca uuuuaccacu     1440

aagagcgcuc ccccuuccca gguguggaac augacaguau caaugaccag ugauaauucu     1500

augcacguga aauguaggcc accccgggac cgcaacggcc cucaugagag auaccaccug     1560

gaggucgaag ccgggaauac ucucgugagg aacgagagcc auaagaauug cgauuuccgg     1620

guuaaggacc ugcaguauuc caccgacuac acauuuaaag cauauuucca caacggagau     1680

uacccaggcg aacccuuuau ccuucaccau ucaacgagcu acaauucuaa ggcccugauu     1740

gcuuucuugg ccuuucucau cauagugacc uccauugcac uguuagucgu gcuguauaaa     1800

aucuacgacc uacacaagaa acgcaguugu aaccucgaug agcaacagga acugguagag     1860

cgagacgaug agaagcagcu uaugaauguu gaaccgaucc augcggacau uuugcuggag     1920

acuuauaaga gaaaaaucgc ugaugaaggu aggcuuuucc uggccgaguu ucagagcauu     1980

ccucgggugu ucucuaaguu cccaauaaaa gaggcacgua agcccuuuaa ccaaaauaaa     2040

aaccgcuacg ucgacauccu uccuuaugau uacaauagag uggaacuguc cgagauuaac     2100

ggggacgccg gaucaaacua uaucaaugcu aguuacaucg auggcuucaa ggaacccagg     2160

aaguacauug ccgcacaggg cccacgggac gagacagucg augacuuuug gcgaaugaua     2220

ugggaacaga aagcuaccgu gaucguuaug gugacacgcu gcgaggaggg gaacagaaau     2280

aagugugccg aauauuggcc uagcauggag gaaggaacua gggcguucgg ugacguaguc     2340

gugaaaauua accagcacaa gcggugcccc gauuacauca uucaaaaauu gaauaucguu     2400

aacaagaaag agaaggccac cggccgcgaa gugacgcaca uacaguuuac aucguggcca     2460

gaccaugggg ucccggagga uccucaccuc cuguuaaagc ugagaaggcg ugugaaugcu     2520

uucuccaacu uuuucucugg acccaucgua gugcauugua gcgcaggcgu uggucggacc     2580

gggacuuaua uuggcaucga cgccaugcua gagggacucg aagcugagaa uaaagucgau     2640

guguacggcu auguggucaa gcugcgaaga cagaggugcc uuaugguuca gguggaagcc     2700

caauacauuu ugauccacca ggcacuggug gaguauaacc aguuugggga aaccgaggua     2760

aaucucucag agcugcaucc auacuuacac aacaugaaaa agcgcgaucc cccuagugaa     2820

ccaucacccc uggaggcgga guuccagcgg cuuccuucuu acagaagcug gaggacacaa     2880

cacauaggaa aucaggaaga gaacaaaucc aagaaucgca acucaaacgu cauuccguau     2940

gacuacaauc gagugccauu gaagcaugaa cucgagauga gcaaagaaag ugagcacgac     3000

ucugaugaau ccagcgacga ugacucggau ucagaggagc ccucuaagua uaucaacgcc     3060

aguuuuauua uguccuacug gaaaccugaa guuaugaucg cugcccaggg uccacugaag     3120

gagacuauag gcgacuucug gcaaaugauc uuucagcgga aagugaaggu cauugugaug     3180

cuaaccgaac ugaagcaugg ggaccaggag aucugugcac aguauugggg agaaggcaaa     3240

caaacauacg gugauauuga gguugaccuc aaggauacgg acaaaagcuc uaccuauacu     3300

cugcgugugu ucgagcuuag acacagcaag aggaaagauu cccgcacagu auaccaguac     3360

caguauacca auuggucagu cgaacaguug cccgcugagc cuaaggaacu gaucaguaug     3420

auacaagugg ugaagcagaa auuaccgcag aagaacagcu cugaggggaa uaaacaucac     3480

aaguccacuc cccuccugau ucacugccgg gacggcucac agcaaacagg aaucuucugu     3540

gcccuucuga acuugcucga aagugcagag accgaggaag ucguugauau cuuucaggug     3600

guaaaagccc ugagaaaggc uaggccaggc auggugagca cguucgagca guaccaauuu     3660

cuauaugacg ucauugcguc cacuuacccu gcccagaaug gacaggugaa aaagaacaau     3720

caucaggaag auaagaucga guucgacaac gagguugaua aagugaagca agacgcaaau     3780

ugcgucaacc cccugggggc uccagaaaaa cucccugagg ccaaggaaca ggccgagggu     3840

ucugaaccca ccucgggcac agaggggcca gagcacagcg ugaauggacc ggcuuccccu     3900

gcacugaacc agggcuccug a                                               3921


<210>  3273
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PTPRC__Homo_sapiens__CCDS1397.2

<400>  3273
augaccaugu accuguggcu gaagcugcug gccuucggcu ucgccuuccu ggacaccgag       60

guguucguga ccggccagag ccccaccccc agccccaccg gccugaccac cgccaagaug      120

cccagcgugc cccugagcag cgacccccug cccacccaca ccaccgccuu cagccccgcc      180

agcaccuucg agagagagaa cgacuucagc gagaccacca ccagccugag ccccgacaac      240

accagcaccc aggugagccc cgacagccug gacaacgcca gcgccuucaa caccaccggc      300

gugagcagcg ugcagacccc ccaccugccc acccacgccg acagccagac ccccagcgcc      360

ggcaccgaca cccagaccuu cagcggcagc gccgccaacg ccaagcugaa ccccaccccc      420

ggcagcaacg ccaucagcga cgugcccggc gagagaagca ccgccagcac cuuccccacc      480

gaccccguga gcccccugac caccacccug agccuggccc accacagcag cgccgcccug      540

cccgccagaa ccagcaacac caccaucacc gccaacacca gcgacgccua ccugaacgcc      600

agcgagacca ccacccugag ccccagcggc agcgccguga ucagcaccac caccaucgcc      660

accaccccca gcaagcccac cugcgacgag aaguacgcca acaucaccgu ggacuaccug      720

uacaacaagg agaccaagcu guucaccgcc aagcugaacg ugaacgagaa cguggagugc      780

ggcaacaaca ccugcaccaa caacgaggug cacaaccuga ccgagugcaa gaacgccagc      840

gugagcauca gccacaacag cugcaccgcc cccgacaaga cccugauccu ggacgugccc      900

cccggcgugg agaaguucca gcugcacgac ugcacccagg uggagaaggc cgacaccacc      960

aucugccuga aguggaagaa caucgagacc uucaccugcg acacccagaa caucaccuac     1020

agauuccagu gcggcaacau gaucuucgac aacaaggaga ucaagcugga gaaccuggag     1080

cccgagcacg aguacaagug cgacagcgag auccuguaca acaaccacaa guucaccaac     1140

gccagcaaga ucaucaagac cgacuucggc agccccggcg agccccagau caucuucugc     1200

agaagcgagg ccgcccacca gggcgugauc accuggaacc ccccccagag aagcuuccac     1260

aacuucaccc ugugcuacau caaggagacc gagaaggacu gccugaaccu ggacaagaac     1320

cugaucaagu acgaccugca gaaccugaag cccuacacca aguacgugcu gagccugcac     1380

gccuacauca ucgccaaggu gcagagaaac ggcagcgccg ccaugugcca cuucaccacc     1440

aagagcgccc cccccagcca gguguggaac augaccguga gcaugaccag cgacaacagc     1500

augcacguga agugcagacc ccccagagac agaaacggcc cccacgagag auaccaccug     1560

gagguggagg ccggcaacac ccuggugaga aacgagagcc acaagaacug cgacuucaga     1620

gugaaggacc ugcaguacag caccgacuac accuucaagg ccuacuucca caacggcgac     1680

uaccccggcg agcccuucau ccugcaccac agcaccagcu acaacagcaa ggcccugauc     1740

gccuuccugg ccuuccugau caucgugacc agcaucgccc ugcugguggu gcuguacaag     1800

aucuacgacc ugcacaagaa gagaagcugc aaccuggacg agcagcagga gcugguggag     1860

agagacgacg agaagcagcu gaugaacgug gagcccaucc acgccgacau ccugcuggag     1920

accuacaaga gaaagaucgc cgacgagggc agacuguucc uggccgaguu ccagagcauc     1980

cccagagugu ucagcaaguu ccccaucaag gaggccagaa agcccuucaa ccagaacaag     2040

aacagauacg uggacauccu gcccuacgac uacaacagag uggagcugag cgagaucaac     2100

ggcgacgccg gcagcaacua caucaacgcc agcuacaucg acggcuucaa ggagcccaga     2160

aaguacaucg ccgcccaggg ccccagagac gagaccgugg acgacuucug gagaaugauc     2220

ugggagcaga aggccaccgu gaucgugaug gugaccagau gcgaggaggg caacagaaac     2280

aagugcgccg aguacuggcc cagcauggag gagggcacca gagccuucgg cgacguggug     2340

gugaagauca accagcacaa gagaugcccc gacuacauca uccagaagcu gaacaucgug     2400

aacaagaagg agaaggccac cggcagagag gugacccaca uccaguucac cagcuggccc     2460

gaccacggcg ugcccgagga cccccaccug cugcugaagc ugagaagaag agugaacgcc     2520

uucagcaacu ucuucagcgg ccccaucgug gugcacugca gcgccggcgu gggcagaacc     2580

ggcaccuaca ucggcaucga cgccaugcug gagggccugg aggccgagaa caagguggac     2640

guguacggcu acguggugaa gcugagaaga cagagaugcc ugauggugca gguggaggcc     2700

caguacaucc ugauccacca ggcccuggug gaguacaacc aguucggcga gaccgaggug     2760

aaccugagcg agcugcaccc cuaccugcac aacaugaaga agagagaccc ccccagcgag     2820

cccagccccc uggaggccga guuccagaga cugcccagcu acagaagcug gagaacccag     2880

cacaucggca accaggagga gaacaagagc aagaacagaa acagcaacgu gauccccuac     2940

gacuacaaca gagugccccu gaagcacgag cuggagauga gcaaggagag cgagcacgac     3000

agcgacgaga gcagcgacga cgacagcgac agcgaggagc ccagcaagua caucaacgcc     3060

agcuucauca ugagcuacug gaagcccgag gugaugaucg ccgcccaggg cccccugaag     3120

gagaccaucg gcgacuucug gcagaugauc uuccagagaa aggugaaggu gaucgugaug     3180

cugaccgagc ugaagcacgg cgaccaggag aucugcgccc aguacugggg cgagggcaag     3240

cagaccuacg gcgacaucga gguggaccug aaggacaccg acaagagcag caccuacacc     3300

cugagagugu ucgagcugag acacagcaag agaaaggaca gcagaaccgu guaccaguac     3360

caguacacca acuggagcgu ggagcagcug cccgccgagc ccaaggagcu gaucagcaug     3420

auccaggugg ugaagcagaa gcugccccag aagaacagca gcgagggcaa caagcaccac     3480

aagagcaccc cccugcugau ccacugcaga gacggcagcc agcagaccgg caucuucugc     3540

gcccugcuga accugcugga gagcgccgag accgaggagg ugguggacau cuuccaggug     3600

gugaaggccc ugagaaaggc cagacccggc auggugagca ccuucgagca guaccaguuc     3660

cuguacgacg ugaucgccag caccuacccc gcccagaacg gccaggugaa gaagaacaac     3720

caccaggagg acaagaucga guucgacaac gagguggaca aggugaagca ggacgccaac     3780

ugcgugaacc cccugggcgc ccccgagaag cugcccgagg ccaaggagca ggccgagggc     3840

agcgagccca ccagcggcac cgagggcccc gagcacagcg ugaacggccc cgccagcccc     3900

gcccugaacc agggcagcug a                                               3921


<210>  3274
<211>  3921
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PTPRC__Homo_sapiens__CCDS1397.2

<400>  3274
augaccaugu accuguggcu caagcugcuu gccuucggcu uugcuuuccu ggacacagag       60

guguuuguca cggggcagag ccccaccccu uccccgacag gacucaccac agccaaaaug      120

cccucuguuc cucugagcuc cgauccccuu ccuacccaca caaccgcguu cucucccgcu      180

agcacguuug aaagagagaa cgacuucucc gaaaccacaa ccucucugag cccugauaau      240

acauccaccc aagugagccc ggacucucuc gauaacgccu ccgccuuuaa uacgacaggc      300

gugagcucug uccagacacc ccaucugccu acccacgcug acucccagac ccccagcgcc      360

gggaccgaua cacagacguu cucuggaucc gcugccaacg cgaagcugaa uccuaccccc      420

ggcagcaacg ccaucuccga cgugccgggg gagcggucua cagcuagcac cuuuccuaca      480

gaucccguuu ccccucucac cacgacacug agccuugccc aucacucuuc cgcugcccug      540

cccgcgcgca ccagcaauac cacaauuacc gccaacacau cugacgcuua ucucaaugcc      600

agcgaaacga ccacacuguc ccccucugga agcgcuguga ucuccaccac aaccauugcc      660

acgaccccua gcaaaccgac augcgaugag aaguacgcca acaucaccgu cgacuaucuu      720

uacaauaaag agacaaagcu guucaccgcu aagcucaacg ugaaugaaaa cguugagugu      780

ggcaauaaca cgugcacaaa caaugaagug cauaaccuga ccgaguguaa aaaugcgucu      840

gucuccauua gccacaacuc uugcacagcc cccgauaaga cccugauccu cgacgugccu      900

cccggcgugg agaaauuuca acugcacgac uguacccagg ucgaaaaggc ugauacaacg      960

aucugccuua aauggaagaa uauugagacc uucacaugug acacccagaa caucacauau     1020

agauuucagu gcgggaauau gauuuucgau aacaaggaaa ucaaacugga gaaucucgaa     1080

ccugagcaug aguacaagug ugacuccgaa auucuguaua acaaucacaa auucaccaac     1140

gccagcaaga ucauuaaaac ggauuuugga ucccccggcg agccgcaaau caucuucugc     1200

cggucugaag ccgcucauca ggggguuauu acauggaauc cuccccagcg cagcuuucac     1260

aacuucaccc uuuguuacau caaggagacc gaaaaagacu gccugaaucu cgauaagaac     1320

cugauuaagu acgaccugca gaaccucaaa ccuuauacaa aguacgugcu gucccuucac     1380

gccuauauca uugcgaaagu gcaaagaaau ggaucugcug ccaugugcca uuuuaccaca     1440

aagagcgcuc ccccuuccca ggucuggaac augacgguga gcaugaccuc ugauaauucc     1500

augcacguua aaugucggcc cccgcgcgac agaaacggcc cucaugagcg guaccaccug     1560

gagguggaag ccgggaauac acucguccgc aacgagagcc auaagaauug cgauuucaga     1620

gugaaggacc ugcaguauuc uaccgacuac acauuuaaag ccuauuucca caacggagau     1680

uaccccggcg aacccuuuau ccuucaccau uccaccagcu acaauucuaa ggcucugauc     1740

gccuuccucg cguuucugau uaucguuacg agcauugccc ugcucguggu ccuguauaaa     1800

aucuacgacc uucacaagaa acgguccugu aaccuggaug agcaacagga acucguggag     1860

cgcgacgaug agaagcagcu gaugaauguc gaaccuauuc augcugacau ccugcuugag     1920

accuauaaga gaaaaaucgc cgaugaaggc cgccucuucc uggcugaguu ucagagcauu     1980

ccgcgggugu ucucuaaguu ccccaucaaa gaggccagaa agccuuuuaa ccaaaauaaa     2040

aaccgguacg uugacauucu gcccuaugau uacaauagag uggaacucuc cgagaucaac     2100

ggggacgcgg gaagcaacua uauuaaugcc uccuacaucg auggcuucaa ggaaccucgc     2160

aaguacauug cugcccaggg gccccgggac gagacagucg augacuuuug gagaaugauc     2220

ugggaacaga aagcuaccgu gaucguuaug gugacacgcu gcgaggaggg aaaccggaau     2280

aagugugccg aauauuggcc uucuauggag gaaggcacca gagccuucgg ggacgucgug     2340

gugaaaauua accagcacaa gcgcugcccc gauuacauca uucaaaaacu gaauaucguu     2400

aacaagaaag agaaggcuac aggacgggaa gucacccaca uucaguuuac gagcuggccg     2460

gaccauggcg ugccugagga uccccaccuu cugcucaagc ugagacgccg ggugaaugcg     2520

uucuccaacu uuuucucugg cccuaucguc gugcauugua gcgccggggu uggaagaaca     2580

ggcaccuaua ucgggauuga cgcuaugcug gagggacuug aagccgagaa uaaaguggau     2640

gucuacggcu augugguuaa gcuccgccgg cagagaugcc ugauggugca ggucgaagcc     2700

caauacaucc ugauucacca ggcucucgug gaguauaacc aguuugggga aaccgagguu     2760

aaucuguccg agcuucaucc cuaccugcac aacaugaaaa agcgggaccc gccuucugaa     2820

cccagcccuc ucgaggccga guuccagcgc cugcccuccu acagaagcug gcggacacaa     2880

cacaucggca aucaggaaga gaacaaaucu aagaauagaa acuccaacgu gauucccuau     2940

gauuacaauc gcgucccucu gaagcaugaa cuugagauga gcaaagaauc ugagcacgac     3000

uccgaugaaa gcucugacga ugacuccgau agcgaggagc cguccaagua uaucaacgcg     3060

agcuuuauca ugucuuacug gaaacccgaa gugaugauug cugcccaggg accucucaag     3120

gagaccaucg gcgacuucug gcaaaugauu uuucagcgga aagugaaggu caucguuaug     3180

cugacggaac ugaagcaugg ggaccaggag auuugugccc aguauugggg agaaggcaaa     3240

caaacauacg gggauaucga gguggaccuc aaggauaccg acaaaagcuc cacauauacc     3300

cugagagugu ucgagcuucg ccacucuaag agaaaagaua gccggacagu cuaccaguac     3360

caguauacca auugguccgu ggaacagcug cccgcugagc cuaaggaacu caucucuaug     3420

auucaaguug ugaagcagaa acugccccag aagaacagcu ccgagggaaa uaaacaucac     3480

aagucuacgc cucugcuuau ccacugccgc gacggcagcc agcaaaccgg gauuuucugu     3540

gcccuccuga accugcucga auccgcggag acagaggaag ucguggauau cuuucagguu     3600

gugaaagcuc ugagaaaggc ccggccgggc auggucagca ccuucgagca guaccaauuu     3660

cuuuaugacg ugauugccuc uacauacccc gcucagaaug gacagguuaa aaagaacaau     3720

caucaggaag auaagaucga guucgacaac gagguggaua aagucaagca agacgccaau     3780

ugcgugaacc cucugggcgc ucccgaaaaa cucccugagg ccaaggaaca ggcggagggg     3840

uccgaaccca ccagcggaac ggagggcccg gagcacucug ugaaugggcc ugccuccccc     3900

gcucugaacc agggaagcug a                                               3921


<210>  3275
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RAB8A__Homo_sapiens__P61006

<400>  3275

Met Ala Lys Thr Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Val Leu Phe Arg Phe Ser Glu Asp Ala 
            20                  25                  30          


Phe Asn Ser Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Glu Lys Ser Phe 
                85                  90                  95      


Asp Asn Ile Arg Asn Trp Ile Arg Asn Ile Glu Glu His Ala Ser Ala 
            100                 105                 110         


Asp Val Glu Lys Met Ile Leu Gly Asn Lys Cys Asp Val Asn Asp Lys 
        115                 120                 125             


Arg Gln Val Ser Lys Glu Arg Gly Glu Lys Leu Ala Leu Asp Tyr Gly 
    130                 135                 140                 


Ile Lys Phe Met Glu Thr Ser Ala Lys Ala Asn Ile Asn Val Glu Asn 
145                 150                 155                 160 


Ala Phe Phe Thr Leu Ala Arg Asp Ile Lys Ala Lys Met Asp Lys Lys 
                165                 170                 175     


Leu Glu Gly Asn Ser Pro Gln Gly Ser Asn Gln Gly Val Lys Ile Thr 
            180                 185                 190         


Pro Asp Gln Gln Lys Arg Ser Ser Phe Phe Arg Cys Val Leu Leu 
        195                 200                 205         


<210>  3276
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RAB8A__Homo_sapiens__AAH02977

<400>  3276
auggcgaaga ccuacgauua ccuguucaag cugcugcuga ucggggacuc gggggugggg       60

aagaccugug uccuguuccg cuucuccgag gacgccuuca acuccacuuu uaucuccacc      120

auaggaauug acuuuaaaau uaggaccaua gagcucgaug gcaagagaau uaaacugcag      180

auaugggaca cagccgguca ggaacgguuu cggacgauca caacggccua cuacaggggu      240

gcaaugggca ucaugcuggu cuacgacauc accaacgaga aguccuucga caacauccgg      300

aacuggauuc gcaacauuga ggagcacgcc ucugcagacg ucgaaaagau gauacucggg      360

aacaagugug augugaauga caagagacaa guuuccaagg aacggggaga aaagcuggcc      420

cucgacuaug gaaucaaguu cauggagacc agcgcgaagg ccaacaucaa uguggaaaau      480

gcauuuuuca cucucgccag agauaucaaa gcaaaaaugg acaaaaaauu ggaaggcaac      540

agcccccagg ggagcaacca gggagucaaa aucacaccgg accagcagaa gaggagcagc      600

uuuuuccgau guguucuucu guga                                             624


<210>  3277
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RAB8A__Homo_sapiens__AAH02977

<400>  3277
auggccaaga ccuacgacua ccuguucaag cuccugcuga ucggcgacag cggggugggc       60

aagaccugcg uccucuuccg cuucuccgag gacgccuuca acagcacguu caucuccacc      120

aucgggaucg acuucaagau ccggaccauc gagcuggacg gcaagcgcau caagcugcag      180

aucugggaca ccgcggggca ggagcgguuc cgcacgauca ccaccgccua cuaccggggc      240

gccaugggca ucaugcucgu guacgacauc accaacgaga aguccuucga caacauccgc      300

aacuggaucc ggaacaucga ggagcacgcc agcgccgacg uggagaagau gauccugggg      360

aacaagugcg acgucaacga caagcgccag gugagcaagg agcggggcga gaagcuggcg      420

cucgacuacg ggaucaaguu cauggagacg uccgccaagg ccaacaucaa cguggagaac      480

gccuucuuca cccuggcgcg cgacaucaag gccaagaugg acaagaagcu ggagggcaac      540

agcccccagg gguccaacca gggcgucaag aucaccccgg accagcagaa gcggagcucc      600

uucuuccgcu gcgugcuccu guga                                             624


<210>  3278
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RAB8A__Homo_sapiens__AAH02977

<400>  3278
auggccaaga ccuacgacua ccucuucaag cuccuccuca ucggcgacuc cggcgucggc       60

aagaccugcg uccucuuccg cuucuccgag gacgccuuca acuccaccuu caucuccacc      120

aucggcaucg acuucaagau ccgcaccauc gagcucgacg gcaagcgcau caagcuccag      180

aucugggaca ccgccggcca ggagcgcuuc cgcaccauca ccaccgccua cuaccgcggc      240

gccaugggca ucaugcucgu cuacgacauc accaacgaga aguccuucga caacauccgc      300

aacuggaucc gcaacaucga ggagcacgcc uccgccgacg ucgagaagau gauccucggc      360

aacaagugcg acgucaacga caagcgccag gucuccaagg agcgcggcga gaagcucgcc      420

cucgacuacg gcaucaaguu cauggagacc uccgccaagg ccaacaucaa cgucgagaac      480

gccuucuuca cccucgcccg cgacaucaag gccaagaugg acaagaagcu cgagggcaac      540

uccccccagg gcuccaacca gggcgucaag aucacccccg accagcagaa gcgcuccucc      600

uucuuccgcu gcguccuccu cuga                                             624


<210>  3279
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RAB8A__Homo_sapiens__AAH02977

<400>  3279
auggccaaga ccuacgacua ucuguucaaa cuccuucuga ucggcgauag ugggguggga       60

aagacaugcg ucuuguuuag auucuccgag gacgcuuuua acucuacuuu cauuucaacg      120

auagguaucg auuuuaaaau uaggaccauc gaauuagacg gcaagcggau uaaacugcag      180

aucugggaua cagcagggca agagcgcuuc cgaacuauaa ccacagccua cuaucgugga      240

gcgaugggca ucaugcuagu uuacgacauu accaaugaaa agaguuuuga uaacaucaga      300

aauuggauua ggaacaucga ggaacacgcu agcgccgacg uggagaagau gauacucggu      360

aauaaaugug auguaaacga caagcggcaa guguccaaag agcgcgggga aaagcuggca      420

cuugauuaug gaauuaaauu cauggagacu ucugccaagg cuaauaucaa cgucgaaaau      480

gcauuuuuca cacuggccag agacauuaag gcuaaaaugg auaagaaauu ggagggcaac      540

ucgccccagg gcucaaauca gggggugaag aucaccccug accagcagaa aaggagcagc      600

uuuuuccggu gcguucuccu guga                                             624


<210>  3280
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RAB8A__Homo_sapiens__AAH02977

<400>  3280
auggccaaga ccuacgacua ccuguucaag cugcugcuga ucggcgacag cggcgugggc       60

aagaccugcg ugcuguucag auucagcgag gacgccuuca acagcaccuu caucagcacc      120

aucggcaucg acuucaagau cagaaccauc gagcuggacg gcaagagaau caagcugcag      180

aucugggaca ccgccggcca ggagagauuc agaaccauca ccaccgccua cuacagaggc      240

gccaugggca ucaugcuggu guacgacauc accaacgaga agagcuucga caacaucaga      300

aacuggauca gaaacaucga ggagcacgcc agcgccgacg uggagaagau gauccugggc      360

aacaagugcg acgugaacga caagagacag gugagcaagg agagaggcga gaagcuggcc      420

cuggacuacg gcaucaaguu cauggagacc agcgccaagg ccaacaucaa cguggagaac      480

gccuucuuca cccuggccag agacaucaag gccaagaugg acaagaagcu ggagggcaac      540

agcccccagg gcagcaacca gggcgugaag aucacccccg accagcagaa gagaagcagc      600

uucuucagau gcgugcugcu guga                                             624


<210>  3281
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RAB8A__Homo_sapiens__AAH02977

<400>  3281
auggccaaga ccuacgacua ucuguucaaa cuccugcuua ucggcgauag cgggguggga       60

aagacaugcg uccuguuuag auucuccgag gacgcuuuua acucuacguu cauuagcacc      120

aucggcauug auuuuaaaau ccggacaauu gaacucgacg ggaagcgcau caaacugcag      180

aucugggaua ccgccggaca agagagauuc cggacaauua ccacagcgua cuaucgcggc      240

gcuaugggga ucaugcuugu uuacgacauu accaaugaaa aguccuuuga uaacaucaga      300

aauuggauuc ggaacaucga ggaacacgcc ucugccgacg uggagaagau gauucuggga      360

aauaaaugug augugaacga caagcgccag gucagcaaag agagaggcga aaagcucgcu      420

cuggauuaug gcaucaaauu cauggagacg uccgccaagg cuaauaucaa cguggaaaau      480

gccuuuuuca cccuggcgcg ggacauuaag gccaaaaugg auaagaaacu cgaggggaac      540

ucuccccagg gaagcaauca gggcguuaag aucacaccug accaacagaa acgcuccagc      600

uuuuucagau gcgugcugcu uuga                                             624


<210>  3282
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RAGE-1__Homo_sapiens__Q9UQ07

<400>  3282

Met Lys Asn Tyr Lys Ala Ile Gly Lys Ile Gly Glu Gly Thr Phe Ser 
1               5                   10                  15      


Glu Val Met Lys Met Gln Ser Leu Arg Asp Gly Asn Tyr Tyr Ala Cys 
            20                  25                  30          


Lys Gln Met Lys Gln Arg Phe Glu Ser Ile Glu Gln Val Asn Asn Leu 
        35                  40                  45              


Arg Glu Ile Gln Ala Leu Arg Arg Leu Asn Pro His Pro Asn Ile Leu 
    50                  55                  60                  


Met Leu His Glu Val Val Phe Asp Arg Lys Ser Gly Ser Leu Ala Leu 
65                  70                  75                  80  


Ile Cys Glu Leu Met Asp Met Asn Ile Tyr Glu Leu Ile Arg Gly Arg 
                85                  90                  95      


Arg Tyr Pro Leu Ser Glu Lys Lys Ile Met His Tyr Met Tyr Gln Leu 
            100                 105                 110         


Cys Lys Ser Leu Asp His Ile His Arg Asn Gly Ile Phe His Arg Asp 
        115                 120                 125             


Val Lys Pro Glu Asn Ile Leu Ile Lys Gln Asp Val Leu Lys Leu Gly 
    130                 135                 140                 


Asp Phe Gly Ser Cys Arg Ser Val Tyr Ser Lys Gln Pro Tyr Thr Glu 
145                 150                 155                 160 


Tyr Ile Ser Thr Arg Trp Tyr Arg Ala Pro Glu Cys Leu Leu Thr Asp 
                165                 170                 175     


Gly Phe Tyr Thr Tyr Lys Met Asp Leu Trp Ser Ala Gly Cys Val Phe 
            180                 185                 190         


Tyr Glu Ile Ala Ser Leu Gln Pro Leu Phe Pro Gly Val Asn Glu Leu 
        195                 200                 205             


Asp Gln Ile Ser Lys Ile His Asp Val Ile Gly Thr Pro Ala Gln Lys 
    210                 215                 220                 


Ile Leu Thr Lys Phe Lys Gln Ser Arg Ala Met Asn Phe Asp Phe Pro 
225                 230                 235                 240 


Phe Lys Lys Gly Ser Gly Ile Pro Leu Leu Thr Thr Asn Leu Ser Pro 
                245                 250                 255     


Gln Cys Leu Ser Leu Leu His Ala Met Val Ala Tyr Asp Pro Asp Glu 
            260                 265                 270         


Arg Ile Ala Ala His Gln Ala Leu Gln His Pro Tyr Phe Gln Glu Gln 
        275                 280                 285             


Arg Lys Thr Glu Lys Arg Ala Leu Gly Ser His Arg Lys Ala Gly Phe 
    290                 295                 300                 


Pro Glu His Pro Val Ala Pro Glu Pro Leu Ser Asn Ser Cys Gln Ile 
305                 310                 315                 320 


Ser Lys Glu Gly Arg Lys Gln Lys Gln Ser Leu Lys Gln Glu Glu Asp 
                325                 330                 335     


Arg Pro Lys Arg Arg Gly Pro Ala Tyr Val Met Glu Leu Pro Lys Leu 
            340                 345                 350         


Lys Leu Ser Gly Val Val Arg Leu Ser Ser Tyr Ser Ser Pro Thr Leu 
        355                 360                 365             


Gln Ser Val Leu Gly Ser Gly Thr Asn Gly Arg Val Pro Val Leu Arg 
    370                 375                 380                 


Pro Leu Lys Cys Ile Pro Ala Ser Lys Lys Thr Asp Pro Gln Lys Asp 
385                 390                 395                 400 


Leu Lys Pro Ala Pro Gln Gln Cys Arg Leu Pro Thr Ile Val Arg Lys 
                405                 410                 415     


Gly Gly Arg 
            


<210>  3283
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RAGE-1__Homo_sapiens__BAA81688

<400>  3283
augaagaacu auaaagcaau uggcaaaaua ggagagggaa cguuuucuga aguuaugaag       60

augcaaagcc ugagagaugg aaacuacuau gcauguaaac aaaugaagca gcgcuuugaa      120

aguauugagc aagucaacaa ccuacgagag auccaagcac ugaggcgccu gaauccgcac      180

ccaaacauuc uuauguugca ugaagugguu uuugacagaa aaucugguuc ucuugcacua      240

auaugugaac uuauggacau gaauauuuau gagcuaauac gagggagaag auacccauua      300

ucagaaaaaa aaauuaugca cuauauguac caguuaugua agucccugga ucauauucac      360

agaaauggaa uauuucacag agauguaaaa ccagaaaaua uacuaauaaa gcaggauguc      420

cugaaauuag gggacuuugg cuccugccgg agugucuauu ccaagcagcc guacacggaa      480

uacaucucca cccgcuggua ccgggccccg gagugucucc ucacugaugg guucuacacg      540

uacaagaugg accuguggag cgccggcugu guguucuacg agaucgccag ucugcagccc      600

cucuuuccug gaguaaauga acuggaccaa aucucaaaaa uccacgaugu caucggcaca      660

cccgcucaga agauccucac caaguucaaa cagucgagag cuaugaauuu ugauuuuccu      720

uuuaaaaagg gaucaggaau accucuacua acaaccaauu uguccccaca augccucucc      780

cuccugcacg caaugguggc cuaugauccc gaugagagaa ucgccgccca ccaggcccug      840

cagcaccccu acuuccaaga acagaggaaa acagagaagc gggcucuggg cagccacaga      900

aaagcuggcu uuccggagca cccuguggca ccggaaccac ucaguaacag cugccagauu      960

uccaaggagg gcagaaagca gaaacagucc cuaaagcaag aggaggaccg ucccaagaga     1020

cgaggaccgg ccuaugucau ggaacugccc aaacuaaagc uuucgggagu ggucagacug     1080

ucgucuuacu ccagccccac gcugcagucc gugcuuggau cuggaacaaa uggaagagug     1140

ccggugcuga gacccuugaa gugcaucccu gcgagcaaga agacagaucc gcagaaggac     1200

cuuaagccug ccccgcagca gugucgccug cccaccauag ugcggaaagg cggaagauaa     1260


<210>  3284
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RAGE-1__Homo_sapiens__BAA81688

<400>  3284
augaagaacu acaaggccau cggcaagauc ggggagggca ccuucagcga ggugaugaag       60

augcaguccc ugcgcgacgg gaacuacuac gccugcaagc agaugaagca gcgguucgag      120

agcaucgagc aggucaacaa ccuccgcgag auccaggccc ugcggcgccu gaacccccac      180

ccgaacaucc ucaugcugca cgagguggug uucgaccgga aguccggcag ccuggcccuc      240

aucugcgagc ugauggacau gaacaucuac gagcugaucc gcgggcggcg cuacccccuc      300

uccgagaaga agaucaugca cuacauguac cagcugugca agagccugga ccacauccac      360

cggaacggca ucuuccaccg cgacgucaag cccgagaaca uccucaucaa gcaggacgug      420

cugaagcugg gcgacuucgg guccugccgg agcguguacu ccaagcagcc cuacaccgag      480

uacaucagca cgcgcuggua ccgggccccg gagugccucc ugaccgacgg cuucuacacc      540

uacaagaugg accugugguc cgccgggugc gucuucuacg agaucgccag ccuccagccc      600

cuguuccccg gcgugaacga gcuggaccag aucuccaaga uccacgacgu gaucgggacc      660

cccgcgcaga agauccucac gaaguucaag cagagccgcg ccaugaacuu cgacuucccg      720

uucaagaagg gcuccggcau cccccugcug accaccaacc ucagccccca gugccugucc      780

cugcuccacg ccauggucgc cuacgacccc gacgagcgga ucgcggccca ccaggcccug      840

cagcacccgu acuuccagga gcagcgcaag accgagaagc gggcccuggg gagccaccgc      900

aaggccggcu uccccgagca ccccguggcg cccgagccgc ucuccaacag cugccagauc      960

agcaaggagg ggcggaagca gaagcagucc cugaagcagg aggaggaccg ccccaagcgg     1020

cgcggccccg ccuacgugau ggagcugccc aagcucaagc ugagcggcgu cgugcgccug     1080

uccagcuacu ccagcccgac gcuccagucc gugcugggga gcggcaccaa cgggcggguc     1140

cccgugcugc gcccccucaa gugcaucccc gccuccaaga agaccgaccc gcagaaggac     1200

cugaagcccg cgccccagca gugccggcug cccaccaucg ugcgcaaggg cgggcgguga     1260


<210>  3285
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RAGE-1__Homo_sapiens__BAA81688

<400>  3285
augaagaacu acaaggccau cggcaagauc ggcgagggca ccuucuccga ggucaugaag       60

augcaguccc uccgcgacgg caacuacuac gccugcaagc agaugaagca gcgcuucgag      120

uccaucgagc aggucaacaa ccuccgcgag auccaggccc uccgccgccu caacccccac      180

cccaacaucc ucaugcucca cgaggucguc uucgaccgca aguccggcuc ccucgcccuc      240

aucugcgagc ucauggacau gaacaucuac gagcucaucc gcggccgccg cuacccccuc      300

uccgagaaga agaucaugca cuacauguac cagcucugca agucccucga ccacauccac      360

cgcaacggca ucuuccaccg cgacgucaag cccgagaaca uccucaucaa gcaggacguc      420

cucaagcucg gcgacuucgg cuccugccgc uccgucuacu ccaagcagcc cuacaccgag      480

uacaucucca cccgcuggua ccgcgccccc gagugccucc ucaccgacgg cuucuacacc      540

uacaagaugg accucugguc cgccggcugc gucuucuacg agaucgccuc ccuccagccc      600

cucuuccccg gcgucaacga gcucgaccag aucuccaaga uccacgacgu caucggcacc      660

cccgcccaga agauccucac caaguucaag cagucccgcg ccaugaacuu cgacuucccc      720

uucaagaagg gcuccggcau cccccuccuc accaccaacc ucucccccca gugccucucc      780

cuccuccacg ccauggucgc cuacgacccc gacgagcgca ucgccgccca ccaggcccuc      840

cagcaccccu acuuccagga gcagcgcaag accgagaagc gcgcccucgg cucccaccgc      900

aaggccggcu uccccgagca ccccgucgcc cccgagcccc ucuccaacuc cugccagauc      960

uccaaggagg gccgcaagca gaagcagucc cucaagcagg aggaggaccg ccccaagcgc     1020

cgcggccccg ccuacgucau ggagcucccc aagcucaagc ucuccggcgu cguccgccuc     1080

uccuccuacu ccucccccac ccuccagucc guccucggcu ccggcaccaa cggccgcguc     1140

cccguccucc gcccccucaa gugcaucccc gccuccaaga agaccgaccc ccagaaggac     1200

cucaagcccg ccccccagca gugccgccuc cccaccaucg uccgcaaggg cggccgcuga     1260


<210>  3286
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RAGE-1__Homo_sapiens__BAA81688

<400>  3286
augaagaacu acaaagccau cggcaagauu ggggagggaa ccuucagcga agugaugaaa       60

augcaguccc ugagagacgg uaauuauuac gcuugcaagc aaaugaaaca gagguuugag      120

ucuauagaac aggucaacaa ucuccgggag auccaggcac uucgccgacu gaacccccac      180

ccuaauauuu ugauguuaca ugaaguugug uucgaucgua agucaggcag ucuggcccua      240

aucugugagc ucauggacau gaacauuuau gagcugauca gagggaggcg guacccacuu      300

agcgaaaaga aaauaaugca cuauauguac caacugugca aguccuugga ucauauccac      360

cgcaauggaa uuuuucauag agacguaaaa ccggagaaca uccucauuaa gcaggaugug      420

cugaaacugg gcgacuucgg uucuuguagg ucggucuauu caaagcagcc cuacacagaa      480

uacaucagca cucgguggua ucgcgcgccu gagugccucu uaacggaugg guuuuacacc      540

uauaagaugg accuguggag ugcuggaugu guguucuacg agauagccuc ccuucagcca      600

uuguuucccg gcguuaauga acuggaucaa auuucuaaaa uccacgacgu gauuggcacu      660

ccugcacaga agauccuaac aaaauucaag cagagccgag ccaugaacuu ugauuuccca      720

uuuaaaaagg gguccggaau cccccuccug accacaaauc uuucaccuca gugccugagu      780

uugcuccacg cuauggucgc auaugaccca gaugagagaa uugccgcuca ucaagcccug      840

cagcacccgu acuuccagga acaaaggaaa accgagaagc gggcguuagg uagccaucgu      900

aaggcaggcu uucccgaaca cccuguggcc ccagagcccc ugucuaacuc cugucagaua      960

ucaaaagagg ggcgcaagca gaaacagagc cucaagcaag aagaggacag accuaaaagg     1020

cggggaccag cuuauguaau ggaacuuccc aagcugaagu ugaguggcgu ugugcgacua     1080

ucuuccuaca gcucgccgac ucugcagucu guccucgguu ccgggacaaa uggacgcgug     1140

ccugugcuga gaccccuuaa augcauccca gccucaaaga aaaccgaccc ucagaaggau     1200

cugaaacccg caccacagca auguagguug cccacgauug uccggaaggg cggccgcuga     1260


<210>  3287
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RAGE-1__Homo_sapiens__BAA81688

<400>  3287
augaagaacu acaaggccau cggcaagauc ggcgagggca ccuucagcga ggugaugaag       60

augcagagcc ugagagacgg caacuacuac gccugcaagc agaugaagca gagauucgag      120

agcaucgagc aggugaacaa ccugagagag auccaggccc ugagaagacu gaacccccac      180

cccaacaucc ugaugcugca cgagguggug uucgacagaa agagcggcag ccuggcccug      240

aucugcgagc ugauggacau gaacaucuac gagcugauca gaggcagaag auacccccug      300

agcgagaaga agaucaugca cuacauguac cagcugugca agagccugga ccacauccac      360

agaaacggca ucuuccacag agacgugaag cccgagaaca uccugaucaa gcaggacgug      420

cugaagcugg gcgacuucgg cagcugcaga agcguguaca gcaagcagcc cuacaccgag      480

uacaucagca ccagauggua cagagccccc gagugccugc ugaccgacgg cuucuacacc      540

uacaagaugg accuguggag cgccggcugc guguucuacg agaucgccag ccugcagccc      600

cuguuccccg gcgugaacga gcuggaccag aucagcaaga uccacgacgu gaucggcacc      660

cccgcccaga agauccugac caaguucaag cagagcagag ccaugaacuu cgacuucccc      720

uucaagaagg gcagcggcau cccccugcug accaccaacc ugagccccca gugccugagc      780

cugcugcacg ccaugguggc cuacgacccc gacgagagaa ucgccgccca ccaggcccug      840

cagcaccccu acuuccagga gcagagaaag accgagaaga gagcccuggg cagccacaga      900

aaggccggcu uccccgagca ccccguggcc cccgagcccc ugagcaacag cugccagauc      960

agcaaggagg gcagaaagca gaagcagagc cugaagcagg aggaggacag acccaagaga     1020

agaggccccg ccuacgugau ggagcugccc aagcugaagc ugagcggcgu ggugagacug     1080

agcagcuaca gcagccccac ccugcagagc gugcugggca gcggcaccaa cggcagagug     1140

cccgugcuga gaccccugaa gugcaucccc gccagcaaga agaccgaccc ccagaaggac     1200

cugaagcccg ccccccagca gugcagacug cccaccaucg ugagaaaggg cggcagauga     1260


<210>  3288
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RAGE-1__Homo_sapiens__BAA81688

<400>  3288
augaagaacu acaaagccau cggcaagauu ggggagggaa ccuucagcga agugaugaaa       60

augcaguccc ugagagacgg caauuauuac gcuugcaagc aaaugaaaca gcgguuugag      120

ucuaucgaac aggucaacaa ucuccgcgag auucaggccc ugagacggcu uaacccccac      180

ccuaauaucc ugaugcucca ugaaguugug uucgaucgca agagcggguc ccuggcgcuu      240

auuugugagc ugauggacau gaacaucuau gagcucauca gaggacggcg cuacccgcug      300

ucugaaaaga aaauuaugca cuauauguac caacugugca agagccucga ucauauccac      360

agaaauggca uuuuucaucg ggacgugaaa cccgagaaca uccugauuaa gcaggauguc      420

cuuaaacugg gggacuucgg auccugucgc ucuguguaua gcaagcagcc uuacacagaa      480

uacaucucca cgagauggua ucgggcuccc gagugccucc ugaccgaugg cuuuuacaca      540

uauaagaugg accuuuggag cgccggcugu guuuucuacg agauugccuc ucugcagccu      600

cucuuucccg gggugaauga acuggaucaa aucuccaaaa uccacgacgu cauuggaacc      660

ccugcucaga agauccugac aaaauucaag cagagccgcg ccaugaacuu ugauuucccg      720

uuuaaaaagg gcucugggau uccccuccug accacaaauc uuuccccuca gugccugagc      780

cuccugcacg cuaugguggc cuaugacccc gaugagagaa ucgcggccca ucaagcccuu      840

cagcacccuu acuuccagga acaacggaaa accgagaagc gcgcucuggg aucucauaga      900

aaggcuggcu uucccgaaca cccgguugcc ccugagcccc ucuccaacag cugucagauu      960

uccaaagagg ggcggaagca gaaacagucu cugaagcaag aagaggacag accuaaacgc     1020

cggggacccg cguaugugau ggaacugccc aagcucaagc ugagcggcgu cgugagacuu     1080

uccagcuacu cuuccccuac gcugcagagc gugcucggcu cugggaccaa uggacgcguc     1140

ccgguucugc ggccccuuaa augcaucccu gccagcaaga aaacagaccc ccagaaggau     1200

cugaaaccug cuccccagca auguagacuc ccgaccaucg ugcgcaaggg cgggcgguga     1260


<210>  3289
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RARA__Homo_sapiens__P10276

<400>  3289

Met Ala Ser Asn Ser Ser Ser Cys Pro Thr Pro Gly Gly Gly His Leu 
1               5                   10                  15      


Asn Gly Tyr Pro Val Pro Pro Tyr Ala Phe Phe Phe Pro Pro Met Leu 
            20                  25                  30          


Gly Gly Leu Ser Pro Pro Gly Ala Leu Thr Thr Leu Gln His Gln Leu 
        35                  40                  45              


Pro Val Ser Gly Tyr Ser Thr Pro Ser Pro Ala Thr Ile Glu Thr Gln 
    50                  55                  60                  


Ser Ser Ser Ser Glu Glu Ile Val Pro Ser Pro Pro Ser Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Arg Ile Tyr Lys Pro Cys Phe Val Cys Gln Asp Lys Ser Ser 
                85                  90                  95      


Gly Tyr His Tyr Gly Val Ser Ala Cys Glu Gly Cys Lys Gly Phe Phe 
            100                 105                 110         


Arg Arg Ser Ile Gln Lys Asn Met Val Tyr Thr Cys His Arg Asp Lys 
        115                 120                 125             


Asn Cys Ile Ile Asn Lys Val Thr Arg Asn Arg Cys Gln Tyr Cys Arg 
    130                 135                 140                 


Leu Gln Lys Cys Phe Glu Val Gly Met Ser Lys Glu Ser Val Arg Asn 
145                 150                 155                 160 


Asp Arg Asn Lys Lys Lys Lys Glu Val Pro Lys Pro Glu Cys Ser Glu 
                165                 170                 175     


Ser Tyr Thr Leu Thr Pro Glu Val Gly Glu Leu Ile Glu Lys Val Arg 
            180                 185                 190         


Lys Ala His Gln Glu Thr Phe Pro Ala Leu Cys Gln Leu Gly Lys Tyr 
        195                 200                 205             


Thr Thr Asn Asn Ser Ser Glu Gln Arg Val Ser Leu Asp Ile Asp Leu 
    210                 215                 220                 


Trp Asp Lys Phe Ser Glu Leu Ser Thr Lys Cys Ile Ile Lys Thr Val 
225                 230                 235                 240 


Glu Phe Ala Lys Gln Leu Pro Gly Phe Thr Thr Leu Thr Ile Ala Asp 
                245                 250                 255     


Gln Ile Thr Leu Leu Lys Ala Ala Cys Leu Asp Ile Leu Ile Leu Arg 
            260                 265                 270         


Ile Cys Thr Arg Tyr Thr Pro Glu Gln Asp Thr Met Thr Phe Ser Asp 
        275                 280                 285             


Gly Leu Thr Leu Asn Arg Thr Gln Met His Asn Ala Gly Phe Gly Pro 
    290                 295                 300                 


Leu Thr Asp Leu Val Phe Ala Phe Ala Asn Gln Leu Leu Pro Leu Glu 
305                 310                 315                 320 


Met Asp Asp Ala Glu Thr Gly Leu Leu Ser Ala Ile Cys Leu Ile Cys 
                325                 330                 335     


Gly Asp Arg Gln Asp Leu Glu Gln Pro Asp Arg Val Asp Met Leu Gln 
            340                 345                 350         


Glu Pro Leu Leu Glu Ala Leu Lys Val Tyr Val Arg Lys Arg Arg Pro 
        355                 360                 365             


Ser Arg Pro His Met Phe Pro Lys Met Leu Met Lys Ile Thr Asp Leu 
    370                 375                 380                 


Arg Ser Ile Ser Ala Lys Gly Ala Glu Arg Val Ile Thr Leu Lys Met 
385                 390                 395                 400 


Glu Ile Pro Gly Ser Met Pro Pro Leu Ile Gln Glu Met Leu Glu Asn 
                405                 410                 415     


Ser Glu Gly Leu Asp Thr Leu Ser Gly Gln Pro Gly Gly Gly Gly Arg 
            420                 425                 430         


Asp Gly Gly Gly Leu Ala Pro Pro Pro Gly Ser Cys Ser Pro Ser Leu 
        435                 440                 445             


Ser Pro Ser Ser Asn Arg Ser Ser Pro Ala Thr His Ser Pro 
    450                 455                 460         


<210>  3290
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RARA__Homo_sapiens__AAH08727

<400>  3290
auggccagca acagcagcuc cugcccgaca ccugggggcg ggcaccucaa uggguacccg       60

gugccucccu acgccuucuu cuuccccccu augcugggug gacucucccc gccaggcgcu      120

cugaccacuc uccagcacca gcuuccaguu aguggauaua gcacaccauc cccagccacc      180

auugagaccc agagcagcag uucugaagag auagugccca gcccucccuc gccacccccu      240

cuaccccgca ucuacaagcc uugcuuuguc ugucaggaca aguccucagg cuaccacuau      300

ggggucagcg ccugugaggg cugcaagggc uucuuccgcc gcagcaucca gaagaacaug      360

guguacacgu gucaccggga caagaacugc aucaucaaca aggugacccg gaaccgcugc      420

caguacugcc gacugcagaa gugcuuugaa gugggcaugu ccaaggaguc ugugagaaac      480

gaccgaaaca agaagaagaa ggaggugccc aagcccgagu gcucugagag cuacacgcug      540

acgccggagg ugggggagcu cauugagaag gugcgcaaag cgcaccagga aaccuucccu      600

gcccucugcc agcugggcaa auacacuacg aacaacagcu cagaacaacg ugucucucug      660

gacauugacc ucugggacaa guucagugaa cucuccacca agugcaucau uaagacugug      720

gaguucgcca agcagcugcc cggcuucacc acccucacca ucgccgacca gaucacccuc      780

cucaaggcug ccugccugga cauccugauc cugcggaucu gcacgcggua cacgcccgag      840

caggacacca ugaccuucuc ggacgggcug acccugaacc ggacccagau gcacaacgcu      900

ggcuucggcc cccucaccga ccuggucuuu gccuucgcca accagcugcu gccccuggag      960

auggaugaug cggagacggg gcugcucagc gccaucugcc ucaucugcgg agaccgccag     1020

gaccuggagc agccggaccg gguggacaug cugcaggagc cgcugcugga ggcgcuaaag     1080

gucuacgugc ggaagcggag gcccagccgc ccccacaugu uccccaagau gcuaaugaag     1140

auuacugacc ugcgaagcau cagcgccaag ggggcugagc gggugaucac gcugaagaug     1200

gagaucccgg gcuccaugcc gccucucauc caggaaaugu uggagaacuc agagggccug     1260

gacacucuga gcggacagcc gggggguggg gggcgggacg gggguggccu ggcccccccg     1320

ccaggcagcu guagccccag ccucagcccc agcuccaaca gaagcagccc ggccacccac     1380

uccccguga                                                             1389


<210>  3291
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RARA__Homo_sapiens__AAH08727

<400>  3291
auggccagca acuccagcuc cugccccacc cccggcgggg gccaccugaa cggguacccc       60

gugccgcccu acgccuucuu cuucccgccc augcucggcg ggcugagccc gcccggcgcg      120

cugaccacgc uccagcacca gcugcccguc uccggcuaca gcacccccuc ccccgccacc      180

aucgagaccc agagcuccag cuccgaggag aucgugccca gcccgcccuc cccgccgccc      240

cugccccgca ucuacaagcc cugcuucgug ugccaggaca agagcuccgg guaccacuac      300

ggcgucagcg ccugcgaggg gugcaagggc uucuuccggc gcuccaucca gaagaacaug      360

guguacacgu gccaccggga caagaacugc aucaucaaca aggugacccg caaccggugc      420

caguacugcc gccuccagaa gugcuucgag gucgggauga gcaaggaguc cgugcggaac      480

gaccgcaaca agaagaagaa ggaggugccc aagcccgagu gcagcgagag cuacacccug      540

acccccgagg ucggcgagcu gaucgagaag gugcggaagg cccaccagga gacguucccc      600

gcccucugcc agcugggcaa guacaccacc aacaacucca gcgagcagcg cgugucccug      660

gacaucgacc ucugggacaa guucagcgag cuguccacca agugcaucau caagacgguc      720

gaguucgcga agcagcugcc cggguucacc acccucacca ucgccgacca gaucacgcug      780

cugaaggccg ccugccucga cauccugauc cugcggaucu gcacccgcua cacccccgag      840

caggacacca ugacguucag cgacggccuc acccugaacc ggacccagau gcacaacgcg      900

ggguucggcc cccugaccga ccucguguuc gccuucgcca accagcugcu gccccucgag      960

auggacgacg ccgagacggg ccugcugucc gccaucugcc ucaucugcgg ggaccgccag     1020

gaccuggagc agcccgaccg gguggacaug cugcaggagc cgcuccugga ggcgcugaag     1080

gucuacgugc gcaagcggcg ccccagccgg ccccacaugu ucccgaagau gcucaugaag     1140

aucaccgacc ugcgcuccau cagcgccaag ggcgccgagc gggugaucac ccugaagaug     1200

gagauccccg gguccaugcc gccccucauc caggagaugc uggagaacag cgagggccug     1260

gacacccucu ccgggcagcc cggcggcggg ggccgcgacg ggggcgggcu ggccccgccg     1320

cccggcagcu gcucccccag ccuguccccc agcuccaacc gcagcagccc cgccacgcac     1380

ucccccuga                                                             1389


<210>  3292
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RARA__Homo_sapiens__AAH08727

<400>  3292
auggccucca acuccuccuc cugccccacc cccggcggcg gccaccucaa cggcuacccc       60

gucccccccu acgccuucuu cuuccccccc augcucggcg gccucucccc ccccggcgcc      120

cucaccaccc uccagcacca gcuccccguc uccggcuacu ccacccccuc ccccgccacc      180

aucgagaccc aguccuccuc cuccgaggag aucguccccu ccccccccuc cccccccccc      240

cucccccgca ucuacaagcc cugcuucguc ugccaggaca aguccuccgg cuaccacuac      300

ggcgucuccg ccugcgaggg cugcaagggc uucuuccgcc gcuccaucca gaagaacaug      360

gucuacaccu gccaccgcga caagaacugc aucaucaaca aggucacccg caaccgcugc      420

caguacugcc gccuccagaa gugcuucgag gucggcaugu ccaaggaguc cguccgcaac      480

gaccgcaaca agaagaagaa ggaggucccc aagcccgagu gcuccgaguc cuacacccuc      540

acccccgagg ucggcgagcu caucgagaag guccgcaagg cccaccagga gaccuucccc      600

gcccucugcc agcucggcaa guacaccacc aacaacuccu ccgagcagcg cgucucccuc      660

gacaucgacc ucugggacaa guucuccgag cucuccacca agugcaucau caagaccguc      720

gaguucgcca agcagcuccc cggcuucacc acccucacca ucgccgacca gaucacccuc      780

cucaaggccg ccugccucga cauccucauc cuccgcaucu gcacccgcua cacccccgag      840

caggacacca ugaccuucuc cgacggccuc acccucaacc gcacccagau gcacaacgcc      900

ggcuucggcc cccucaccga ccucgucuuc gccuucgcca accagcuccu cccccucgag      960

auggacgacg ccgagaccgg ccuccucucc gccaucugcc ucaucugcgg cgaccgccag     1020

gaccucgagc agcccgaccg cgucgacaug cuccaggagc cccuccucga ggcccucaag     1080

gucuacgucc gcaagcgccg ccccucccgc ccccacaugu uccccaagau gcucaugaag     1140

aucaccgacc uccgcuccau cuccgccaag ggcgccgagc gcgucaucac ccucaagaug     1200

gagauccccg gcuccaugcc cccccucauc caggagaugc ucgagaacuc cgagggccuc     1260

gacacccucu ccggccagcc cggcggcggc ggccgcgacg gcggcggccu cgcccccccc     1320

cccggcuccu gcucccccuc ccucuccccc uccuccaacc gcuccucccc cgccacccac     1380

ucccccuga                                                             1389


<210>  3293
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RARA__Homo_sapiens__AAH08727

<400>  3293
auggccagca acuccucuuc augccccacc ccuggcgggg gacaccugaa ugguuaccca       60

gugccgcccu augcuuucuu uuucccucca augcucggcg ggcuuagucc cccuggagca      120

cugacaacuu ugcagcauca auuaccaguc agcggcuacu ccacgcccuc uccugccacc      180

aucgagacac agucgucaag cagugaggag auuguuccau ccccgcccuc uccuccaccc      240

cugccuagaa uauauaagcc auguuuugug ugccaggaca aaagcuccgg uuaccacuau      300

gggguaucag cgugugaagg augcaagggc uucuuuaggc ggaguaucca gaaaaacaug      360

guguacacuu gucaucgcga uaagaauugc auuaucaaca aagucacccg aaaucguugu      420

caauauugca gacuacagaa guguuucgag gugggcauga gcaaggaauc uguuaggaac      480

gaccggaaua aaaagaaaaa ggaggugccc aaaccggagu gcuccgaauc auacacacuc      540

accccugagg ucggggaacu gauugagaag gugcgcaagg cucaccagga gacuuuuccc      600

gcccuuuguc agcugggaaa auacacaacc aacaauagca gugaacaaag aguaucuuug      660

gauaucgacc ucugggauaa guucuccgag cugagcacga aaugcauaau caagacuguu      720

gaauuugcaa aacagcugcc agguuucacc acacucacua uugccgacca gaucaccuua      780

cugaaggcug caugccuuga uauuuugauc cugaggauau guacacggua uaccccugag      840

caggacacga ugacuuuuuc ggauggccua acacucaacc gcacccaaau gcauaaugcc      900

ggguucggac cccugacuga ccuuguguuu gcuuucgcca accagcuguu gccacucgaa      960

auggaugacg cggagacagg ccuguuaucu gcaauuugcc ugaucugugg ugaucgacag     1020

gaccucgagc aacccgacag agucgauaug cuucaggaac cucuguugga ggcccuaaaa     1080

guguacguga ggaagcggcg uccaucccgc ccgcacaugu uccccaagau gcugaugaaa     1140

auuaccgacc ucagaucaau cagugcuaag ggggccgaaa gggucaucac gcugaaaaug     1200

gagauuccug gaagcaugcc accccuuaua caggaaaugc uggaaaauuc cgagggcuug     1260

gauacccucu cuggccagcc ugggggaggu ggccgggacg ggggaggccu ggcaccaccc     1320

ccggguagcu gcucaccuag uuuaucccca agcucuaacc gaucaagucc cgcuacacac     1380

agcccuuga                                                             1389


<210>  3294
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RARA__Homo_sapiens__AAH08727

<400>  3294
auggccagca acagcagcag cugccccacc cccggcggcg gccaccugaa cggcuacccc       60

gugccccccu acgccuucuu cuuccccccc augcugggcg gccugagccc ccccggcgcc      120

cugaccaccc ugcagcacca gcugcccgug agcggcuaca gcacccccag ccccgccacc      180

aucgagaccc agagcagcag cagcgaggag aucgugccca gcccccccag cccccccccc      240

cugcccagaa ucuacaagcc cugcuucgug ugccaggaca agagcagcgg cuaccacuac      300

ggcgugagcg ccugcgaggg cugcaagggc uucuucagaa gaagcaucca gaagaacaug      360

guguacaccu gccacagaga caagaacugc aucaucaaca aggugaccag aaacagaugc      420

caguacugca gacugcagaa gugcuucgag gugggcauga gcaaggagag cgugagaaac      480

gacagaaaca agaagaagaa ggaggugccc aagcccgagu gcagcgagag cuacacccug      540

acccccgagg ugggcgagcu gaucgagaag gugagaaagg cccaccagga gaccuucccc      600

gcccugugcc agcugggcaa guacaccacc aacaacagca gcgagcagag agugagccug      660

gacaucgacc ugugggacaa guucagcgag cugagcacca agugcaucau caagaccgug      720

gaguucgcca agcagcugcc cggcuucacc acccugacca ucgccgacca gaucacccug      780

cugaaggccg ccugccugga cauccugauc cugagaaucu gcaccagaua cacccccgag      840

caggacacca ugaccuucag cgacggccug acccugaaca gaacccagau gcacaacgcc      900

ggcuucggcc cccugaccga ccugguguuc gccuucgcca accagcugcu gccccuggag      960

auggacgacg ccgagaccgg ccugcugagc gccaucugcc ugaucugcgg cgacagacag     1020

gaccuggagc agcccgacag aguggacaug cugcaggagc cccugcugga ggcccugaag     1080

guguacguga gaaagagaag acccagcaga ccccacaugu uccccaagau gcugaugaag     1140

aucaccgacc ugagaagcau cagcgccaag ggcgccgaga gagugaucac ccugaagaug     1200

gagauccccg gcagcaugcc cccccugauc caggagaugc uggagaacag cgagggccug     1260

gacacccuga gcggccagcc cggcggcggc ggcagagacg gcggcggccu ggcccccccc     1320

cccggcagcu gcagccccag ccugagcccc agcagcaaca gaagcagccc cgccacccac     1380

agccccuga                                                             1389


<210>  3295
<211>  1389
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RARA__Homo_sapiens__AAH08727

<400>  3295
auggccagca acuccucuag cugccccacc ccuggcgggg gacaccugaa uggcuacccg       60

gugcccccuu augcuuucuu uuucccuccc augcucgggg gacugucucc cccuggcgcc      120

cuuacaacgc ugcagcauca acucccgguc uccggguaca gcacccccuc cccugcgaca      180

aucgagaccc agucuagcuc cagcgaagag auuguucccu cuccucccuc cccgccuccc      240

cugccuagaa ucuauaagcc cuguuuugug ugccaggaca aaagcucugg auaccacuau      300

ggcguguccg cuugugaagg cugcaagggg uucuuucggc gcagcauuca gaaaaacaug      360

gucuacacau gucauagaga uaagaauugc aucauuaaca aagugacccg gaaucgcugu      420

caauauugca gacuucagaa guguuucgag guuggaaugu cuaaggaauc cgugcggaac      480

gaccgcaaua aaaagaaaaa ggaggucccc aaaccugagu gcagcgaauc cuacacacug      540

accccggagg ugggcgaacu caucgagaag guuagaaagg cccaccagga gacguuuccc      600

gcccuguguc agcuggggaa auacaccaca aacaauucua gcgaacaacg ggugucccuc      660

gauaucgacc ugugggauaa guucagcgag cuuucuacca aaugcauuau caagacaguc      720

gaauuugcua aacagcugcc uggauucacc acgcucacaa uugccgacca gaucacccug      780

cuuaaggcug ccugccugga uauucucauc cugcgcauuu guacaagaua uacccccgag      840

caggacacca ugacauuuuc cgauggccug acgcucaacc ggacccaaau gcauaaugcg      900

ggguucggac cucugacaga ccuuguguuu gccuucgcua accagcugcu cccccuggaa      960

auggaugacg ccgagaccgg ccuucugagc gcuaucugcc ucaucugugg cgaucgccag     1020

gaccuggagc aaccggacag aguggauaug cugcaggaac cucuccugga ggcccuuaaa     1080

gucuacguuc ggaagcgcag acccucucgg ccucacaugu uccccaagau gcugaugaaa     1140

auuacagacc ucagaagcau cuccgcgaag ggggccgaac gcgugauuac ccugaaaaug     1200

gagaucccug gaucuaugcc cccgcuuauu caggaaaugc uggagaauag cgagggccuc     1260

gauacgcugu ccgggcagcc uggaggcggg ggacgggacg gcggcgggcu ggcucccccu     1320

cccggaagcu gcucuccguc ccucagcccc ucuuccaaca gaagcucccc ugccacacac     1380

ucucccuga                                                             1389


<210>  3296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RASH__Homo_sapiens__P01112

<400>  3296

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  3297
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RASH__Homo_sapiens__AAB02605

<400>  3297
augacggaau auaagcuggu gguggugggc gccggcggug ugggcaagag ugcgcugacc       60

auccagcuga uccagaacca uuuuguggac gaauacgacc ccacuauaga ggauuccuac      120

cggaagcagg uggucauuga uggggagacg ugccuguugg acauccugga uaccgccggc      180

caggaggagu acagcgccau gcgggaccag uacaugcgca ccggggaggg cuuccugugu      240

guguuugcca ucaacaacac caagucuuuu gaggacaucc accaguacag ggagcagauc      300

aaacggguga aggacucgga ugacgugccc auggugcugg uggggaacaa gugugaccug      360

gcugcacgca cuguggaauc ucggcaggcu caggaccucg cccgaagcua cggcaucccc      420

uacaucgaga ccucggccaa gacccggcag ggaguggagg augccuucua cacguuggug      480

cgugagaucc ggcagcacaa gcugcggaag cugaacccuc cugaugagag uggccccggc      540

ugcaugagcu gcaagugugu gcucuccuga                                       570


<210>  3298
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RASH__Homo_sapiens__AAB02605

<400>  3298
augaccgagu acaagcuggu ggucgugggc gccgggggcg ugggcaagag cgcccucacc       60

auccagcuga uccagaacca cuucgucgac gaguacgacc ccacgaucga ggacuccuac      120

cgcaagcagg ucgugaucga cggggagacc ugccugcucg acauccugga caccgcgggg      180

caggaggagu acagcgccau gcgggaccag uacaugcgca ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacac gaaguccuuc gaggacaucc accaguaccg ggagcagauc      300

aagcgcguga aggacagcga cgacgugccg augguccucg uggggaacaa gugcgaccug      360

gccgcccgga ccguggaguc ccgccaggcg caggaccugg cccggagcua cggcaucccc      420

uacaucgaga ccuccgccaa gacccgccag ggggucgagg acgccuucua cacgcucgug      480

cgggagaucc gccagcacaa gcugcggaag cugaacccgc ccgacgagag cggccccggg      540

ugcauguccu gcaagugcgu gcucagcuga                                       570


<210>  3299
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RASH__Homo_sapiens__AAB02605

<400>  3299
augaccgagu acaagcucgu cgucgucggc gccggcggcg ucggcaaguc cgcccucacc       60

auccagcuca uccagaacca cuucgucgac gaguacgacc ccaccaucga ggacuccuac      120

cgcaagcagg ucgucaucga cggcgagacc ugccuccucg acauccucga caccgccggc      180

caggaggagu acuccgccau gcgcgaccag uacaugcgca ccggcgaggg cuuccucugc      240

gucuucgcca ucaacaacac caaguccuuc gaggacaucc accaguaccg cgagcagauc      300

aagcgcguca aggacuccga cgacgucccc augguccucg ucggcaacaa gugcgaccuc      360

gccgcccgca ccgucgaguc ccgccaggcc caggaccucg cccgcuccua cggcaucccc      420

uacaucgaga ccuccgccaa gacccgccag ggcgucgagg acgccuucua cacccucguc      480

cgcgagaucc gccagcacaa gcuccgcaag cucaaccccc ccgacgaguc cggccccggc      540

ugcauguccu gcaagugcgu ccucuccuga                                       570


<210>  3300
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RASH__Homo_sapiens__AAB02605

<400>  3300
augaccgagu acaagcuggu ggucguuggc gccgggggag uggguaaaag cgcucucaca       60

auccagcuua uucaaaacca cuucguagac gaauaugauc ccacuauaga ggacuccuac      120

agaaaacagg uggucaucga uggcgaaacg ugccuguugg acauuuuaga uaccgcaggg      180

caggaggaau auucugccau gagggaccag uacaugcgga caggagaggg cuuucugugu      240

guguucgcga ucaauaacac uaagucauuu gaggauauuc aucaauaucg cgaacagauc      300

aagcgaguua aagacaguga ugacgugccu augguccuag uggguaauaa gugcgaucuc      360

gcugcccgua ccguagagag cagacaggca caggaccugg ccagguccua cgggauacca      420

uauaucgaaa caucugcuaa gacccggcaa ggaguugagg augcauucua cacucuugug      480

cgcgagauua gacagcacaa acugaggaag uugaacccgc ccgacgaauc gggcccuggc      540

uguaugucau gcaaaugugu ccucagcuga                                       570


<210>  3301
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RASH__Homo_sapiens__AAB02605

<400>  3301
augaccgagu acaagcuggu gguggugggc gccggcggcg ugggcaagag cgcccugacc       60

auccagcuga uccagaacca cuucguggac gaguacgacc ccaccaucga ggacagcuac      120

agaaagcagg uggugaucga cggcgagacc ugccugcugg acauccugga caccgccggc      180

caggaggagu acagcgccau gagagaccag uacaugagaa ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacac caagagcuuc gaggacaucc accaguacag agagcagauc      300

aagagaguga aggacagcga cgacgugccc auggugcugg ugggcaacaa gugcgaccug      360

gccgccagaa ccguggagag cagacaggcc caggaccugg ccagaagcua cggcaucccc      420

uacaucgaga ccagcgccaa gaccagacag ggcguggagg acgccuucua cacccuggug      480

agagagauca gacagcacaa gcugagaaag cugaaccccc ccgacgagag cggccccggc      540

ugcaugagcu gcaagugcgu gcugagcuga                                       570


<210>  3302
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RASH__Homo_sapiens__AAB02605

<400>  3302
augaccgagu acaagcuggu ggucguuggc gccgggggag ugggcaaaag cgcucucaca       60

auccagcuga uucaaaacca cuucguggac gaauaugauc ccacgaucga ggacuccuac      120

agaaagcagg ucgugauuga uggggaaacc ugccuucugg acauccucga uacagccgga      180

caggaggaau auucugcgau gcgggaccag uacaugcgca ccggcgaggg guuucugugu      240

guuuucgcua uuaacaacac aaagagcuuu gaggauaucc aucaauauag agaacagauc      300

aaacggguga aagacuccga ugacgucccu auggugcuug uuggaaauaa gugcgaucug      360

gccgcccgca ccguggaguc uagacaggcu caggaccucg cccggagcua cggcauuccg      420

uauaucgaaa cauccgcuaa gacccgccaa ggcgucgagg augccuucua cacgcuggug      480

agagagauuc ggcagcacaa acugcgcaag cucaaucccc cugacgaauc ugggcccgga      540

uguaugagcu gcaaaugugu gcuguccuga                                       570


<210>  3303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RASK__Homo_sapiens__P01116

<400>  3303

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  3304
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RASK__Homo_sapiens__AAB59445

<400>  3304
augacugaau auaaacuugu gguaguugga gcugguggcg uaggcaagag ugccuugacg       60

auacagcuaa uucagaauca uuuuguggac gaauaugauc caacaauaga ggauuccuac      120

aggaagcaag uaguaauuga uggagaaacc ugucucuugg auauucucga cacagcaggu      180

caagaggagu acagugcaau gagggaccag uacaugagga cuggggaggg cuuucuuugu      240

guauuugcca uaaauaauac uaaaucauuu gaagauauuc accauuauag agaacaaauu      300

aaaagaguua aggacucuga agauguaccu augguccuag uaggaaauaa augugauuug      360

ccuucuagaa caguagacac aaaacaggcu caggacuuag caagaaguua uggaauuccu      420

uuuauugaaa caucagcaaa gacaagacag agaguggagg augcuuuuua uacauuggug      480

agagagaucc gacaauacag auugaaaaaa aucagcaaag aagaaaagac uccuggcugu      540

gugaaaauua aaaaaugcau uauaauguaa                                       570


<210>  3305
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RASK__Homo_sapiens__AAB59445

<400>  3305
augaccgagu acaagcuggu ggucgugggc gccgggggcg ugggcaagag cgcccucacc       60

auccagcuga uccagaacca cuucgucgac gaguacgacc ccacgaucga ggacuccuac      120

cgcaagcagg ucgugaucga cggggagacc ugccugcucg acauccugga caccgcgggg      180

caggaggagu acagcgccau gcgggaccag uacaugcgca ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacac gaaguccuuc gaggacaucc accacuaccg ggagcagauc      300

aagcgcguga aggacagcga ggacgugccg augguccucg uggggaacaa gugcgaccug      360

cccucccgga ccguggacac caagcaggcc caggaccugg cccgcagcua cggcaucccc      420

uucaucgaga ccuccgcgaa gacgcggcag cgcgucgagg acgccuucua cacccucgug      480

cgggagaucc gccaguaccg gcugaagaag aucagcaagg aggagaagac ccccgggugc      540

gugaagauca agaagugcau caucauguga                                       570


<210>  3306
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RASK__Homo_sapiens__AAB59445

<400>  3306
augaccgagu acaagcucgu cgucgucggc gccggcggcg ucggcaaguc cgcccucacc       60

auccagcuca uccagaacca cuucgucgac gaguacgacc ccaccaucga ggacuccuac      120

cgcaagcagg ucgucaucga cggcgagacc ugccuccucg acauccucga caccgccggc      180

caggaggagu acuccgccau gcgcgaccag uacaugcgca ccggcgaggg cuuccucugc      240

gucuucgcca ucaacaacac caaguccuuc gaggacaucc accacuaccg cgagcagauc      300

aagcgcguca aggacuccga ggacgucccc augguccucg ucggcaacaa gugcgaccuc      360

cccucccgca ccgucgacac caagcaggcc caggaccucg cccgcuccua cggcaucccc      420

uucaucgaga ccuccgccaa gacccgccag cgcgucgagg acgccuucua cacccucguc      480

cgcgagaucc gccaguaccg ccucaagaag aucuccaagg aggagaagac ccccggcugc      540

gucaagauca agaagugcau caucauguga                                       570


<210>  3307
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RASK__Homo_sapiens__AAB59445

<400>  3307
augaccgagu acaagcuggu ggucguuggc gccgggggag uggguaaaag cgcucucaca       60

auccagcuua uucaaaacca cuucguagac gaauaugauc ccacuauaga ggacuccuac      120

agaaaacagg uggucaucga uggcgaaacg ugccuguugg acauuuuaga uaccgcaggg      180

caggaggaau auucugccau gagggaccag uacaugcgga caggagaggg cuuucugugu      240

guguucgcga ucaauaacac uaagucauuu gaggauauuc aucacuaucg cgaacaaauc      300

aagcgaguua aagacaguga ggaugugccu augguccuag uggguaauaa gugcgaccuc      360

ccaagccgua ccguagauac aaagcaggcu caggaccugg ccagauccua cgggauaccg      420

uucaucgaaa ccucugcaaa aacuaggcag cggguugagg augccuuuua uacacuugug      480

cgcgagauua gacaauacag gcugaagaaa aucucgaagg aagagaaaac ccccggaugu      540

gucaagauua agaaaugcau cauaauguga                                       570


<210>  3308
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RASK__Homo_sapiens__AAB59445

<400>  3308
augaccgagu acaagcuggu gguggugggc gccggcggcg ugggcaagag cgcccugacc       60

auccagcuga uccagaacca cuucguggac gaguacgacc ccaccaucga ggacagcuac      120

agaaagcagg uggugaucga cggcgagacc ugccugcugg acauccugga caccgccggc      180

caggaggagu acagcgccau gagagaccag uacaugagaa ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacac caagagcuuc gaggacaucc accacuacag agagcagauc      300

aagagaguga aggacagcga ggacgugccc auggugcugg ugggcaacaa gugcgaccug      360

cccagcagaa ccguggacac caagcaggcc caggaccugg ccagaagcua cggcaucccc      420

uucaucgaga ccagcgccaa gaccagacag agaguggagg acgccuucua cacccuggug      480

agagagauca gacaguacag acugaagaag aucagcaagg aggagaagac ccccggcugc      540

gugaagauca agaagugcau caucauguga                                       570


<210>  3309
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RASK__Homo_sapiens__AAB59445

<400>  3309
augaccgagu acaagcuggu ggucguuggc gccgggggag ugggcaaaag cgcucucaca       60

auccagcuga uucaaaacca cuucguggac gaauaugauc ccacgaucga ggacuccuac      120

agaaagcagg ucgugauuga uggggaaacc ugccuucugg acauccucga uacagccgga      180

caggaggaau auucugcgau gcgggaccag uacaugcgca ccggcgaggg guuucugugu      240

guuuucgcua uuaauaacac aaagagcuuu gaggauaucc aucacuauag agaacaaauc      300

aaacggguga aagacuccga ggaugucccu auggugcuug uuggaaauaa gugcgaccug      360

ccgucucgca ccguggauac aaagcaggcc caggaccucg ccagaagcua cggcauuccc      420

uucaucgaaa ccuccgcuaa aacgcggcag cgcgucgagg augccuuuua uacccuggug      480

agagagauuc ggcaauaccg ccugaagaaa aucucuaagg aagagaaaac accuggcugu      540

gugaagauua agaaaugcau cauuauguga                                       570


<210>  3310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RASN__Homo_sapiens__P01111

<400>  3310

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  3311
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RASN__Homo_sapiens__AAA60255

<400>  3311
augacugagu acaaacuggu ggugguugga gcagguggug uugggaaaag cgcacugaca       60

auccagcuaa uccagaacca cuuuguagau gaauaugauc ccaccauaga ggauucuuac      120

agaaaacaag ugguuauaga uggugaaacc uguuuguugg acauacugga uacagcugga      180

caagaagagu acagugccau gagagaccaa uacaugagga caggcgaagg cuuccucugu      240

guauuugcca ucaauaauag caagucauuu gcggauauua accucuacag ggagcagauu      300

aagcgaguaa aagacucgga ugauguaccu auggugcuag ugggaaacaa gugugauuug      360

ccaacaagga caguugauac aaaacaagcc cacgaacugg ccaagaguua cgggauucca      420

uucauugaaa ccucagccaa gaccagacag gguguugaag augcuuuuua cacacuggua      480

agagaaauac gccaguaccg aaugaaaaaa cucaacagca gugaugaugg gacucagggu      540

uguaugggau ugccaugugu ggugauguaa                                       570


<210>  3312
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RASN__Homo_sapiens__AAA60255

<400>  3312
augaccgagu acaagcuggu ggucgugggc gccgggggcg ugggcaagag cgcccucacc       60

auccagcuga uccagaacca cuucgucgac gaguacgacc ccacgaucga ggacuccuac      120

cgcaagcagg ucgugaucga cggggagacc ugccugcucg acauccugga caccgcgggg      180

caggaggagu acagcgccau gcgggaccag uacaugcgca ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacuc caagagcuuc gccgacauca accucuaccg ggagcagauc      300

aagcgcguga aggacuccga cgacgugccg augguccugg uggggaacaa gugcgaccug      360

cccacgcgga ccguggacac caagcaggcc cacgagcucg ccaagagcua cggcaucccc      420

uucaucgaga ccuccgcgaa gacgcgccag ggggucgagg acgccuucua cacccuggug      480

cgggagaucc gccaguaccg gaugaagaag cugaacagcu ccgacgacgg cacccagggg      540

ugcaugggcc uccccugcgu ggucauguga                                       570


<210>  3313
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RASN__Homo_sapiens__AAA60255

<400>  3313
augaccgagu acaagcucgu cgucgucggc gccggcggcg ucggcaaguc cgcccucacc       60

auccagcuca uccagaacca cuucgucgac gaguacgacc ccaccaucga ggacuccuac      120

cgcaagcagg ucgucaucga cggcgagacc ugccuccucg acauccucga caccgccggc      180

caggaggagu acuccgccau gcgcgaccag uacaugcgca ccggcgaggg cuuccucugc      240

gucuucgcca ucaacaacuc caaguccuuc gccgacauca accucuaccg cgagcagauc      300

aagcgcguca aggacuccga cgacgucccc augguccucg ucggcaacaa gugcgaccuc      360

cccacccgca ccgucgacac caagcaggcc cacgagcucg ccaaguccua cggcaucccc      420

uucaucgaga ccuccgccaa gacccgccag ggcgucgagg acgccuucua cacccucguc      480

cgcgagaucc gccaguaccg caugaagaag cucaacuccu ccgacgacgg cacccagggc      540

ugcaugggcc uccccugcgu cgucauguga                                       570


<210>  3314
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RASN__Homo_sapiens__AAA60255

<400>  3314
augaccgagu acaagcuggu ggucguuggc gccgggggag uggguaaaag cgcucucaca       60

auccagcuua uucaaaacca cuucguagac gaauaugauc ccacuauaga ggacuccuac      120

agaaaacagg uggucaucga uggcgaaacg ugccuguugg acauuuuaga uaccgcaggg      180

caggaggaau auucugccau gagggaccag uacaugcgga caggagaggg cuuucugugu      240

guguucgcga ucaauaacuc aaagaguuuu gcugauauua aucuauaucg cgagcaaauc      300

aagcgaguua aagacagcga ugacgugccu augguccucg uggguaacaa gugcgaucug      360

ccaacucgua ccguagacac aaagcaggcc caugaacuug caaaauccua cgggauaccg      420

uucaucgaga ccucugccaa gacuagacag ggaguugaag augcuuuuua uacacuggug      480

agggagauuc ggcaguaccg caugaaaaag cucaauucgu cagacgacgg cacccaaggc      540

uguauggggu ugcccugcgu cgugauguga                                       570


<210>  3315
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RASN__Homo_sapiens__AAA60255

<400>  3315
augaccgagu acaagcuggu gguggugggc gccggcggcg ugggcaagag cgcccugacc       60

auccagcuga uccagaacca cuucguggac gaguacgacc ccaccaucga ggacagcuac      120

agaaagcagg uggugaucga cggcgagacc ugccugcugg acauccugga caccgccggc      180

caggaggagu acagcgccau gagagaccag uacaugagaa ccggcgaggg cuuccugugc      240

guguucgcca ucaacaacag caagagcuuc gccgacauca accuguacag agagcagauc      300

aagagaguga aggacagcga cgacgugccc auggugcugg ugggcaacaa gugcgaccug      360

cccaccagaa ccguggacac caagcaggcc cacgagcugg ccaagagcua cggcaucccc      420

uucaucgaga ccagcgccaa gaccagacag ggcguggagg acgccuucua cacccuggug      480

agagagauca gacaguacag aaugaagaag cugaacagca gcgacgacgg cacccagggc      540

ugcaugggcc ugcccugcgu ggugauguga                                       570


<210>  3316
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RASN__Homo_sapiens__AAA60255

<400>  3316
augaccgagu acaagcuggu ggucguuggc gccgggggag ugggcaaaag cgcucucaca       60

auccagcuga uucaaaacca cuucguggac gaauaugauc ccacgaucga ggacuccuac      120

agaaagcagg ucgugauuga uggggaaacc ugccuucugg acauccucga uacagccgga      180

caggaggaau auucugcgau gcgggaccag uacaugcgca ccggcgaggg guuucugugu      240

guuuucgcua uuaauaacag caaauccuuu gccgauauca aucuuuauag agagcaaauc      300

aagcggguga aagacucuga ugacgucccu auggugcugg uuggaaacaa gugcgaucuc      360

ccgacacgca ccguggacac aaagcaggcc caugaacugg cuaaaagcua cggcauuccc      420

uucaucgaga ccuccgccaa gacgagacag ggcgucgaag augcuuuuua uacccuggug      480

cgggagauuc gccaguacag aaugaaaaag cucaauucua gcgacgacgg gacacaagga      540

uguaugggcc ugccuugcgu ggucauguga                                       570


<210>  3317
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RGS5__Homo_sapiens__O15539

<400>  3317

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
    130                 135                 140                 


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
145                 150                 155                 160 


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
                165                 170                 175     


Gln Glu Leu Ile Lys 
            180     


<210>  3318
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RGS5__Homo_sapiens__AAB84001

<400>  3318
augugcaaag gacuugcagc uuugccccac ucaugccugg aaagggccaa ggagauuaag       60

aucaaguugg gaauucuccu ccagaagcca gacucaguug gugaccuugu cauuccguac      120

aaugagaagc cagagaaacc agccaagacc cagaaaaccu cgcuggacga ggcccugcag      180

uggcgugauu cccuggacaa acuccugcag aacaacuaug gacuugccag uuucaaaagu      240

uuccugaagu cugaauucag ugaggaaaac cuugaguucu ggauugccug ugaggauuac      300

aagaagauca aguccccugc caagauggcu gagaaggcaa agcaaauuua ugaagaauuc      360

auucaaacgg aggcuccuaa agaggugaau auugaccacu ucacuaagga caucacaaug      420

aagaaccugg uggaaccuuc ccugagcagc uuugacaugg cccagaaaag aauccaugcc      480

cugauggaaa aggauucucu gccucgcuuu gugcgcucug aguuuuauca ggaguuaauc      540

aaguag                                                                 546


<210>  3319
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RGS5__Homo_sapiens__AAB84001

<400>  3319
augugcaagg gccuggccgc ccucccccac agcugccugg agcgcgcgaa ggagaucaag       60

aucaagcugg ggauccuccu gcagaagccg gacuccgugg gcgaccuggu cauccccuac      120

aacgagaagc ccgagaagcc cgccaagacc cagaagacca gccucgacga ggcccugcag      180

uggcgggacu cccuggacaa gcuccugcag aacaacuacg ggcuggccag cuucaagucc      240

uuccucaaga gcgaguucuc cgaggagaac cuggaguucu ggaucgccug cgaggacuac      300

aagaagauca agagcccggc gaagauggcc gagaaggcca agcagaucua cgaggaguuc      360

auccagacgg aggcccccaa ggaggugaac aucgaccacu ucaccaagga caucaccaug      420

aagaaccugg uggagcccuc ccucagcucc uucgacaugg cgcagaagcg cauccacgcc      480

cugauggaga aggacagccu gccccgguuc guccgcuccg aguucuacca ggagcucauc      540

aaguga                                                                 546


<210>  3320
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RGS5__Homo_sapiens__AAB84001

<400>  3320
augugcaagg gccucgccgc ccucccccac uccugccucg agcgcgccaa ggagaucaag       60

aucaagcucg gcauccuccu ccagaagccc gacuccgucg gcgaccucgu cauccccuac      120

aacgagaagc ccgagaagcc cgccaagacc cagaagaccu cccucgacga ggcccuccag      180

uggcgcgacu cccucgacaa gcuccuccag aacaacuacg gccucgccuc cuucaagucc      240

uuccucaagu ccgaguucuc cgaggagaac cucgaguucu ggaucgccug cgaggacuac      300

aagaagauca agucccccgc caagauggcc gagaaggcca agcagaucua cgaggaguuc      360

auccagaccg aggcccccaa ggaggucaac aucgaccacu ucaccaagga caucaccaug      420

aagaaccucg ucgagcccuc ccucuccucc uucgacaugg cccagaagcg cauccacgcc      480

cucauggaga aggacucccu cccccgcuuc guccgcuccg aguucuacca ggagcucauc      540

aaguga                                                                 546


<210>  3321
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RGS5__Homo_sapiens__AAB84001

<400>  3321
augugcaagg gccuggccgc ucucccccac agcugucuug agagagcaaa agaaaucaag       60

auuaaacugg ggauauuguu acagaagccu gacuccgugg gagaucuggu caucccauac      120

aacgagaaac cggaaaagcc cgccaagacc cagaaaacau cucuagacga ggcgcuccaa      180

uggagggauu cacuggacaa acuucugcag aauaacuaug guuuggcuag uuucaagagc      240

uuucucaagu ccgaguucuc ugaagagaau cuggaauuuu ggauugccug cgaggauuac      300

aaaaagauca agucgccugc aaaaauggcc gaaaaggcua aacagauuua ugaggaguuc      360

auccaaacug aagcaccaaa ggagguuaac auagaccauu uuacgaaaga uaucaccaug      420

aagaaucugg uggaacccuc acucagcagu uucgacaugg cccagaaacg gauucacgcu      480

uuaauggaga aggauucccu gccucgcuuu guacgaucug aguucuacca ggaacuuauc      540

aaguga                                                                 546


<210>  3322
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RGS5__Homo_sapiens__AAB84001

<400>  3322
augugcaagg gccuggccgc ccugccccac agcugccugg agagagccaa ggagaucaag       60

aucaagcugg gcauccugcu gcagaagccc gacagcgugg gcgaccuggu gauccccuac      120

aacgagaagc ccgagaagcc cgccaagacc cagaagacca gccuggacga ggcccugcag      180

uggagagaca gccuggacaa gcugcugcag aacaacuacg gccuggccag cuucaagagc      240

uuccugaaga gcgaguucag cgaggagaac cuggaguucu ggaucgccug cgaggacuac      300

aagaagauca agagccccgc caagauggcc gagaaggcca agcagaucua cgaggaguuc      360

auccagaccg aggcccccaa ggaggugaac aucgaccacu ucaccaagga caucaccaug      420

aagaaccugg uggagcccag ccugagcagc uucgacaugg cccagaagag aauccacgcc      480

cugauggaga aggacagccu gcccagauuc gugagaagcg aguucuacca ggagcugauc      540

aaguga                                                                 546


<210>  3323
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RGS5__Homo_sapiens__AAB84001

<400>  3323
augugcaagg gccuggccgc ucucccccac agcugucugg agagagccaa agaaaucaag       60

auuaaacuug ggauccugcu ccagaagccu gacuccgugg gagaucuggu cauuccguac      120

aacgagaaac ccgaaaagcc ugcgaagacc caaaagacau cucuugacga ggcucugcag      180

uggcgggaua gccucgacaa gcugcugcag aauaacuaug gccucgccuc cuucaaaucu      240

uuucugaaaa gcgaguucuc cgaagagaau cuugaauuuu ggaucgccug cgaggauuac      300

aaaaagauua agucucccgc uaaaauggcc gaaaaggcua aacagaucua ugaggaguuc      360

auccaaacgg aagccccuaa ggagguuaac auugaccauu uuaccaaaga uaucacaaug      420

aagaaucugg uggaacccag ccucuccagc uucgacaugg cgcagaaacg cauucacgcc      480

cugauggaga aggauucucu uccuagauuu gugcgguccg aguucuacca ggaacugauc      540

aaguga                                                                 546


<210>  3324
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RHAMM/CD168__Homo_sapiens__O75330

<400>  3324

Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 
1               5                   10                  15      


Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 
            20                  25                  30          


Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 
        35                  40                  45              


Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Glu Ser Gln Lys Asn 
65                  70                  75                  80  


Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu Gln 
                85                  90                  95      


Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu Leu 
            100                 105                 110         


Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser 
        115                 120                 125             


Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr 
    130                 135                 140                 


Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln 
145                 150                 155                 160 


Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn Lys 
                165                 170                 175     


Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met Glu 
            180                 185                 190         


Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys 
        195                 200                 205             


Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys Ile 
    210                 215                 220                 


Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile 
225                 230                 235                 240 


Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln 
                245                 250                 255     


Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys 
            260                 265                 270         


Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu Asp 
        275                 280                 285             


Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His Val 
    290                 295                 300                 


Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln Asn 
305                 310                 315                 320 


Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln 
                325                 330                 335     


Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu 
            340                 345                 350         


Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met Val 
        355                 360                 365             


Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu 
    370                 375                 380                 


Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val Lys 
385                 390                 395                 400 


Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu 
                405                 410                 415     


Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala 
            420                 425                 430         


Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met 
        435                 440                 445             


Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala 
    450                 455                 460                 


Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu 
465                 470                 475                 480 


Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln His 
                485                 490                 495     


Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met Leu 
            500                 505                 510         


Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu 
        515                 520                 525             


Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly 
545                 550                 555                 560 


Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile 
                565                 570                 575     


Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro 
            580                 585                 590         


Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu Leu 
        595                 600                 605             


Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser 
    610                 615                 620                 


Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys His 
625                 630                 635                 640 


Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val Ser 
                645                 650                 655     


Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu 
            660                 665                 670         


Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro Ser 
        675                 680                 685             


Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro 
    690                 695                 700                 


Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln 
705                 710                 715                 720 


Glu Ser Trp Lys 
                


<210>  3325
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3325
auguccuuuc cuaaggcgcc cuugaaacga uucaaugacc cuucugguug ugcaccaucu       60

ccaggugcuu augauguuaa aacuuuagaa guauugaaag gaccaguauc cuuucagaaa      120

ucacaaagau uuaaacaaca aaaagaaucu aaacaaaauc uuaauguuga caaagauacu      180

accuugccug cuucagcuag aaaaguuaag ucuucggaau caaaggaauc ucaaaagaau      240

gauaaagauu ugaagauauu agagaaagag auucguguuc uucuacagga acguggugcc      300

caggacaggc ggauccagga ucuggaaacu gaguuggaaa agauggaagc aaggcuaaau      360

gcugcacuaa gggaaaaaac aucucucucu gcaaauaaug cuacacugga aaaacaacuu      420

auugaauuga ccaggacuaa ugaacuacua aaaucuaagu uuucugaaaa ugguaaccag      480

aagaauuuga gaauucuaag cuuggaguug augaaacuua gaaacaaaag agaaacaaag      540

augaggggua ugauggcuaa gcaagaaggc auggagauga agcugcaggu cacccaaagg      600

agucucgaag agucucaagg gaaaauagcc caacuggagg gaaaacuugu uucaauagag      660

aaagaaaaga uugaugaaaa aucugaaaca gaaaaacucu uggaauacau cgaagaaauu      720

aguugugcuu cagaucaagu ggaaaaauac aagcuagaua uugcccaguu agaagaaaau      780

uugaaagaga agaaugauga aauuuuaagc cuuaagcagu cucuugagga gaauauuguu      840

auauuaucua aacaaguaga agaucuaaau gugaaauguc agcugcuuga aaaagaaaaa      900

gaagaccaug ucaacaggaa uagagaacac aacgaaaauc uaaaugcaga gaugcaaaac      960

uuaaaacaga aguuuauucu ugaacaacag gaacgugaaa agcuucaaca aaaagaauua     1020

caaauugauu cacuucugca acaagagaaa gaauuaucuu cgagucuuca ucagaagcuc     1080

uguucuuuuc aagaggaaau gguuaaagag aagaaucugu uugaggaaga auuaaagcaa     1140

acacuggaug agcuugauaa auuacagcaa aaggaggaac aagcugaaag gcuggucaag     1200

caauuggaag aggaagcaaa aucuagagcu gaagaauuaa aacuccuaga agaaaagcug     1260

aaagggaagg aggcugaacu ggagaaaagu agugcugcuc auacccaggc cacccugcuu     1320

uugcaggaaa aguaugacag uauggugcaa agccuugaag auguuacugc ucaauuugaa     1380

agcuauaaag cguuaacagc cagugagaua gaagaucuua agcuggagaa cucaucauua     1440

caggaaaaag cggccaaggc ugggaaaaau gcagaggaug uucagcauca gauuuuggca     1500

acugagagcu caaaucaaga auauguaagg augcuucuag aucugcagac caagucagca     1560

cuaaaggaaa cagaaauuaa agaaaucaca guuucuuuuc uucaaaaaau aacugauuug     1620

cagaaccaac ucaagcaaca ggaggaagac uuuagaaaac agcuggaaga ugaagaagga     1680

agaaaagcug aaaaagaaaa uacaacagca gaauuaacug aagaaauuaa caaguggcgu     1740

cuccucuaug aagaacuaua uaauaaaaca aaaccuuuuc agcuacaacu agaugcuuuu     1800

gaaguagaaa aacaggcauu guugaaugaa cauggugcag cucaggaaca gcuaaauaaa     1860

auaagagauu cauaugcuaa auuauugggu caucagaauu ugaaacaaaa aaucaagcau     1920

guugugaagu ugaaagauga aaauagccaa cucaaaucgg aaguaucaaa acuccgcugu     1980

cagcuugcua aaaaaaaaca aagugagaca aaacuucaag aggaauugaa uaaaguucua     2040

gguaucaaac acuuugaucc uucaaaggcu uuucaucaug aaaguaaaga aaauuuugcc     2100

cugaagaccc cauuaaaaga aggcaauaca aacuguuacc gagcuccuau ggagugucaa     2160

gaaucaugga aguaa                                                      2175


<210>  3326
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3326
augagcuucc ccaaggcccc gcugaagcgc uucaacgacc ccuccggcug cgcccccagc       60

cccggggcgu acgacgugaa gacccucgag guccugaagg gcccgguguc cuuccagaag      120

ucccagcggu ucaagcagca gaaggagagc aagcagaacc ugaacgugga caaggacacc      180

acgcuccccg ccagcgcccg caaggucaag uccagcgagu ccaaggagag ccagaagaac      240

gacaaggacc ugaagauccu ggagaaggag auccgggugc uccugcagga gcgcggggcc      300

caggaccggc gcauccagga ccuggagacc gagcucgaga agauggaggc ccggcugaac      360

gcggcccugc gcgagaagac cucccucagc gccaacaacg ccacccugga gaagcagcug      420

aucgagcuca cgcggaccaa cgagcugcug aaguccaagu ucagcgagaa cggcaaccag      480

aagaaccucc gcauccuguc ccuggagcuc augaagcugc ggaacaagcg cgagaccaag      540

augcggggga ugauggcgaa gcaggagggc auggagauga agcuccaggu gacccagcgc      600

agccuggagg agucccaggg caagaucgcc cagcuggagg ggaagcuggu cagcaucgag      660

aaggagaaga ucgacgagaa guccgagacg gagaagcucc uggaguacau cgaggagauc      720

agcugcgcca gcgaccaggu ggagaaguac aagcuggaca ucgcccagcu cgaggagaac      780

cugaaggaga agaacgacga gauccugucc cucaagcaga gccuggagga gaacaucgug      840

auccugucca agcaggucga ggaccucaac gugaagugcc agcugcugga gaaggagaag      900

gaggaccacg ugaaccggaa ccgcgagcac aacgagaacc ucaacgccga gaugcagaac      960

cugaagcaga aguucauccu ggagcagcag gagcgggaga agcuccagca gaaggagcug     1020

cagaucgaca gccugcucca gcaggagaag gagcugucca gcucccugca ccagaagcuc     1080

ugcagcuucc aggaggagau ggucaaggag aagaaccugu ucgaggagga gcugaagcag     1140

acccuggacg agcucgacaa gcugcagcag aaggaggagc aggcggagcg ccuggugaag     1200

cagcucgagg aggaggccaa gucccgggcc gaggagcuga agcugcucga ggagaagcug     1260

aagggcaagg aggccgagcu ggagaagucc agcgccgcgc acacccaggc cacccuccug     1320

cugcaggaga aguacgacag cauggugcag ucccucgagg acgucacggc ccaguucgag     1380

agcuacaagg cccugaccgc cuccgagauc gaggaccuga agcucgagaa cagcucccug     1440

caggagaagg cggccaaggc cgggaagaac gccgaggacg ugcagcacca gauccuggcc     1500

accgagagcu ccaaccagga guacgugcgc augcuccugg accugcagac caagagcgcg     1560

cucaaggaga cggagaucaa ggagaucacc gucagcuucc ugcagaagau caccgaccug     1620

cagaaccagc ucaagcagca ggaggaggac uuccggaagc agcuggagga cgaggagggc     1680

cgcaaggccg agaaggagaa caccacggcc gagcugaccg aggagaucaa caaguggcgc     1740

cuccuguacg aggagcugua caacaagacc aagcccuucc agcuccagcu ggacgccuuc     1800

gagguggaga agcaggcgcu gcucaacgag cacggggccg cccaggagca gcugaacaag     1860

auccgggacu ccuacgccaa gcugcucggc caccagaacc ugaagcagaa gaucaagcac     1920

guggucaagc ugaaggacga gaacagccag cucaaguccg aggugagcaa gcugcgcugc     1980

cagcuggcca agaagaagca guccgagacc aagcuccagg aggagcugaa caaggugcug     2040

ggcaucaagc acuucgaccc cagcaaggcg uuccaccacg aguccaagga gaacuucgcc     2100

cucaagacgc cgcugaagga ggggaacacc aacugcuacc gggcccccau ggagugccag     2160

gagagcugga aguga                                                      2175


<210>  3327
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3327
auguccuucc ccaaggcccc ccucaagcgc uucaacgacc ccuccggcug cgcccccucc       60

cccggcgccu acgacgucaa gacccucgag guccucaagg gccccgucuc cuuccagaag      120

ucccagcgcu ucaagcagca gaaggagucc aagcagaacc ucaacgucga caaggacacc      180

acccuccccg ccuccgcccg caaggucaag uccuccgagu ccaaggaguc ccagaagaac      240

gacaaggacc ucaagauccu cgagaaggag auccgcgucc uccuccagga gcgcggcgcc      300

caggaccgcc gcauccagga ccucgagacc gagcucgaga agauggaggc ccgccucaac      360

gccgcccucc gcgagaagac cucccucucc gccaacaacg ccacccucga gaagcagcuc      420

aucgagcuca cccgcaccaa cgagcuccuc aaguccaagu ucuccgagaa cggcaaccag      480

aagaaccucc gcauccucuc ccucgagcuc augaagcucc gcaacaagcg cgagaccaag      540

augcgcggca ugauggccaa gcaggagggc auggagauga agcuccaggu cacccagcgc      600

ucccucgagg agucccaggg caagaucgcc cagcucgagg gcaagcucgu cuccaucgag      660

aaggagaaga ucgacgagaa guccgagacc gagaagcucc ucgaguacau cgaggagauc      720

uccugcgccu ccgaccaggu cgagaaguac aagcucgaca ucgcccagcu cgaggagaac      780

cucaaggaga agaacgacga gauccucucc cucaagcagu cccucgagga gaacaucguc      840

auccucucca agcaggucga ggaccucaac gucaagugcc agcuccucga gaaggagaag      900

gaggaccacg ucaaccgcaa ccgcgagcac aacgagaacc ucaacgccga gaugcagaac      960

cucaagcaga aguucauccu cgagcagcag gagcgcgaga agcuccagca gaaggagcuc     1020

cagaucgacu cccuccucca gcaggagaag gagcucuccu ccucccucca ccagaagcuc     1080

ugcuccuucc aggaggagau ggucaaggag aagaaccucu ucgaggagga gcucaagcag     1140

acccucgacg agcucgacaa gcuccagcag aaggaggagc aggccgagcg ccucgucaag     1200

cagcucgagg aggaggccaa gucccgcgcc gaggagcuca agcuccucga ggagaagcuc     1260

aagggcaagg aggccgagcu cgagaagucc uccgccgccc acacccaggc cacccuccuc     1320

cuccaggaga aguacgacuc caugguccag ucccucgagg acgucaccgc ccaguucgag     1380

uccuacaagg cccucaccgc cuccgagauc gaggaccuca agcucgagaa cuccucccuc     1440

caggagaagg ccgccaaggc cggcaagaac gccgaggacg uccagcacca gauccucgcc     1500

accgaguccu ccaaccagga guacguccgc augcuccucg accuccagac caaguccgcc     1560

cucaaggaga ccgagaucaa ggagaucacc gucuccuucc uccagaagau caccgaccuc     1620

cagaaccagc ucaagcagca ggaggaggac uuccgcaagc agcucgagga cgaggagggc     1680

cgcaaggccg agaaggagaa caccaccgcc gagcucaccg aggagaucaa caaguggcgc     1740

cuccucuacg aggagcucua caacaagacc aagcccuucc agcuccagcu cgacgccuuc     1800

gaggucgaga agcaggcccu ccucaacgag cacggcgccg cccaggagca gcucaacaag     1860

auccgcgacu ccuacgccaa gcuccucggc caccagaacc ucaagcagaa gaucaagcac     1920

gucgucaagc ucaaggacga gaacucccag cucaaguccg aggucuccaa gcuccgcugc     1980

cagcucgcca agaagaagca guccgagacc aagcuccagg aggagcucaa caagguccuc     2040

ggcaucaagc acuucgaccc cuccaaggcc uuccaccacg aguccaagga gaacuucgcc     2100

cucaagaccc cccucaagga gggcaacacc aacugcuacc gcgcccccau ggagugccag     2160

gaguccugga aguga                                                      2175


<210>  3328
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3328
augagcuucc ccaaggcccc ucugaaaaga uuuaacgacc cauccggcug cgcuccgucu       60

cccggggcau acgaugugaa gacccucgag guccuuaaag gaccuguuuc auuccagaag      120

agucaaaggu uuaaacagca gaaggaaagc aagcagaauc ugaacgugga caaagauaca      180

acuuugccag ccuccgcgcg gaagguaaaa ucuucggagu caaaggaaag ccaaaagaau      240

gacaaggauu uaaagauccu ggagaaagaa auucgcgugc uacuccagga gcgaggugcu      300

caggaccgua gaauacagga ucuggagacg gaacuugaga agauggaagc caggcugaac      360

gcagccuugc gggagaaaac cagucucucc gcuaauaacg caacacugga gaagcaacug      420

aucgaacuca cucgcaccaa ugaguuacug aaaucuaagu ucagcgaaaa cggcaaucag      480

aaaaaccuua gaauuuuguc ccuggagcua augaagcuca ggaauaagcg ggaaacaaaa      540

augcgcggga ugauggccaa gcaggaggga auggagauga aacugcaggu cacccaacga      600

ucacuugaag agagucaggg caagaucgcu cagcuggaag guaaauuggu gagcauugag      660

aaggaaaaga ucgacgagaa aucugagacu gaaaagcucc uggaguauau agaagagauc      720

uccugugccu cagaucaagu ugaaaaauac aaguuagaca uugcgcagcu ggaggagaac      780

cucaaagaaa agaaugauga gauccuuagc cugaagcaga guuuggaaga gaacauugug      840

auccuaucua aacaggucga ggaccugaau gugaagugcc aacuccugga aaaagagaag      900

gaagaucacg uaaacagaaa cagggagcau aaugaaaacc uuaaugcaga gaugcagaac      960

cugaaacaga aguuuauauu ggagcagcaa gaacgggaga agcuccagca gaaagaacug     1020

cagauugacu ccuuacugca acaggagaag gaacuaagcu cgucucucca ccagaaacug     1080

uguuccuucc aggaggagau gguuaaggag aaaaaucuuu uugaagaaga guugaagcaa     1140

acacuggacg aacucgauaa acugcagcag aaggaggagc aagccgaacg ucuugugaag     1200

cagcuggagg aagaggcuaa aucacgcgcc gaggaauuga agcuccugga ggaaaaauua     1260

aaggggaaag aggcagaacu ggagaagagu agcgcugccc auacccaggc gacgcuacuc     1320

cugcaggaga aguaugacuc caugguccaa ucucuugaag augugacugc ccaguucgag     1380

agcuacaaag cauugaccgc uucagaaauc gaggaccuga agcucgaaaa caguucccug     1440

caggagaaag ccgcuaaggc cggcaaaaau gcagaggaug ugcagcacca aauuuuagcc     1500

acagaaagcu cuaaccagga guaugucaga augcugcuug acuugcagac uaagucagcu     1560

cucaaggaaa ccgagaucaa agaaaucaca guuaguuuuc ugcagaagau uaccgaucua     1620

caaaaucagc ugaaacagca agaggaggac uucaggaagc agcucgaaga ugaggaagga     1680

cggaaagcgg agaaggagaa cacgacugca gaacugacag aggaaauaaa uaaguggcga     1740

cuuuuguacg aggaacugua uaacaaaacc aagcccuuuc aguuacagcu cgacgccuuc     1800

gagguggaga aacaagcucu gcuuaaugaa cauggcgccg cacaggagca gcugaacaag     1860

auccgcgaua gcuacgccaa auugcucggg caccagaauc ugaagcagaa aauuaagcac     1920

guagugaagc uaaaagacga aaacucccaa cugaagucug aggucucgaa acucagaugc     1980

cagcuggcua agaaaaagca gagcgaaacu aaacuucaag aggaguugaa caaagugcug     2040

ggaaucaagc auuuugaccc uuccaaagcc uuccaccaug aaucaaagga gaauuucgca     2100

uuaaaaacac cacucaagga agguaacacc aauuguuaca gggcgcccau ggagugccag     2160

gaaaguugga aguga                                                      2175


<210>  3329
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3329
augagcuucc ccaaggcccc ccugaagaga uucaacgacc ccagcggcug cgcccccagc       60

cccggcgccu acgacgugaa gacccuggag gugcugaagg gccccgugag cuuccagaag      120

agccagagau ucaagcagca gaaggagagc aagcagaacc ugaacgugga caaggacacc      180

acccugcccg ccagcgccag aaaggugaag agcagcgaga gcaaggagag ccagaagaac      240

gacaaggacc ugaagauccu ggagaaggag aucagagugc ugcugcagga gagaggcgcc      300

caggacagaa gaauccagga ccuggagacc gagcuggaga agauggaggc cagacugaac      360

gccgcccuga gagagaagac cagccugagc gccaacaacg ccacccugga gaagcagcug      420

aucgagcuga ccagaaccaa cgagcugcug aagagcaagu ucagcgagaa cggcaaccag      480

aagaaccuga gaauccugag ccuggagcug augaagcuga gaaacaagag agagaccaag      540

augagaggca ugauggccaa gcaggagggc auggagauga agcugcaggu gacccagaga      600

agccuggagg agagccaggg caagaucgcc cagcuggagg gcaagcuggu gagcaucgag      660

aaggagaaga ucgacgagaa gagcgagacc gagaagcugc uggaguacau cgaggagauc      720

agcugcgcca gcgaccaggu ggagaaguac aagcuggaca ucgcccagcu ggaggagaac      780

cugaaggaga agaacgacga gauccugagc cugaagcaga gccuggagga gaacaucgug      840

auccugagca agcaggugga ggaccugaac gugaagugcc agcugcugga gaaggagaag      900

gaggaccacg ugaacagaaa cagagagcac aacgagaacc ugaacgccga gaugcagaac      960

cugaagcaga aguucauccu ggagcagcag gagagagaga agcugcagca gaaggagcug     1020

cagaucgaca gccugcugca gcaggagaag gagcugagca gcagccugca ccagaagcug     1080

ugcagcuucc aggaggagau ggugaaggag aagaaccugu ucgaggagga gcugaagcag     1140

acccuggacg agcuggacaa gcugcagcag aaggaggagc aggccgagag acuggugaag     1200

cagcuggagg aggaggccaa gagcagagcc gaggagcuga agcugcugga ggagaagcug     1260

aagggcaagg aggccgagcu ggagaagagc agcgccgccc acacccaggc cacccugcug     1320

cugcaggaga aguacgacag cauggugcag agccuggagg acgugaccgc ccaguucgag     1380

agcuacaagg cccugaccgc cagcgagauc gaggaccuga agcuggagaa cagcagccug     1440

caggagaagg ccgccaaggc cggcaagaac gccgaggacg ugcagcacca gauccuggcc     1500

accgagagca gcaaccagga guacgugaga augcugcugg accugcagac caagagcgcc     1560

cugaaggaga ccgagaucaa ggagaucacc gugagcuucc ugcagaagau caccgaccug     1620

cagaaccagc ugaagcagca ggaggaggac uucagaaagc agcuggagga cgaggagggc     1680

agaaaggccg agaaggagaa caccaccgcc gagcugaccg aggagaucaa caaguggaga     1740

cugcuguacg aggagcugua caacaagacc aagcccuucc agcugcagcu ggacgccuuc     1800

gagguggaga agcaggcccu gcugaacgag cacggcgccg cccaggagca gcugaacaag     1860

aucagagaca gcuacgccaa gcugcugggc caccagaacc ugaagcagaa gaucaagcac     1920

guggugaagc ugaaggacga gaacagccag cugaagagcg aggugagcaa gcugagaugc     1980

cagcuggcca agaagaagca gagcgagacc aagcugcagg aggagcugaa caaggugcug     2040

ggcaucaagc acuucgaccc cagcaaggcc uuccaccacg agagcaagga gaacuucgcc     2100

cugaagaccc cccugaagga gggcaacacc aacugcuaca gagcccccau ggagugccag     2160

gagagcugga aguga                                                      2175


<210>  3330
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RHAMM/CD168__Homo_sapiens__CCDS4362.1

<400>  3330
augagcuucc ccaaggcccc ucugaaaaga uuuaacgacc cguccggcug cgcucccucu       60

ccuggggccu acgaugugaa gacccucgag guccugaaag gacccguuag cuuccagaag      120

ucccaacggu uuaaacagca gaaggaaucu aagcagaauc uuaacgugga caaagauaca      180

acgcugccug cgagcgcucg caaggugaaa uccucugaga gcaaggaauc ccaaaagaau      240

gacaaggauc ucaagauccu ggagaaagaa auuagagucc uucugcagga gcggggcgcc      300

caggaccgca gaauccagga ucucgagacc gaacuggaga agauggaagc ccggcugaac      360

gcugcccucc gcgagaaaac aagccugucu gcuaauaacg ccacccuuga gaagcaacug      420

auugaacuca caagaaccaa ugagcugcuu aaauccaagu ucagcgaaaa cgggaaucag      480

aaaaaccugc ggauccucuc ucuggagcug augaagcucc gcaauaagag agaaacaaaa      540

augcggggaa ugauggcgaa gcaggagggc auggagauga aacuucaggu gacccaacgc      600

ucccuggaag agagccaggg gaagauugcc cagcuggaag gaaaacucgu uucuaucgag      660

aaggaaaaga ucgacgagaa auccgagacg gaaaagcugc uugaguauau ugaagagauc      720

agcugugcuu ccgaucaagu ggaaaaauac aagcuggaca uugcccagcu cgaggagaac      780

cugaaagaaa agaaugauga gauccugucu cucaagcaga gccuggaaga gaacauuguc      840

auccuuucca aacaggugga ggaccugaau guuaagugcc aacuccugga aaaagagaag      900

gaagaucacg ugaacagaaa ccgggagcau aaugaaaacc uuaaugcuga gaugcagaac      960

cugaaacaga aguuuauucu cgagcagcaa gaacgcgaga agcugcagca gaaagaacug     1020

cagaucgaca gccuccugca acaggagaag gaacuuucuu ccagccugca ccagaaacuc     1080

uguucuuucc aggaggagau ggucaaggaa aagaaucugu uugaggagga acugaagcaa     1140

acccuugacg aacucgauaa acugcagcag aaggaggagc aagccgaaag acuggugaag     1200

cagcucgagg aagaggcgaa aagccgggcc gaggaacuga aacuucugga ggaaaaacuc     1260

aagggcaaag aggcugaacu ggagaagucc ucugccgcuc auacacaggc cacccugcuu     1320

cuccaggaga aguaugacag cauggugcaa ucccuggaag augucacagc ccaguucgag     1380

agcuacaaag cucugaccgc gucugaaauc gaggaccuca agcuggaaaa cuccagccuu     1440

caggagaaag ccgcuaaggc cggcaaaaau gccgaggaug uucagcacca aauucuggcu     1500

acggaaucuu ccaaccagga guaugugaga augcuccugg accugcagac aaagagcgcc     1560

cuuaaggaaa ccgagaucaa agaaauuaca guguccuuuc uccagaagau caccgaucug     1620

caaaaucagc ugaaacagca agaggaggac uuccgcaagc agcucgaaga ugaggaaggg     1680

cggaaagcgg agaaggagaa caccacagcu gaacugacgg aggaaauuaa uaaguggaga     1740

cuucuguacg aggaacucua uaacaaaacc aagcccuuuc agcugcagcu ggacgccuuc     1800

gaggucgaga aacaagcccu ucucaaugaa cauggagcug cccaggagca gcugaacaag     1860

auccgcgauu cuuacgcuaa acugcucggc caccagaauc ugaagcagaa aaucaagcac     1920

gugguuaaac uuaaagacga aaacagccaa cugaaguccg aggugucuaa acuccggugc     1980

cagcuggcca agaaaaagca gagcgaaaca aagcugcaag aggagcuuaa caaaguccug     2040

gggauuaagc auuuugaccc uuccaaagcg uuccaccaug aaagcaagga gaauuucgcc     2100

cucaaaaccc cgcugaagga aggaaacaca aauuguuaca gagcucccau ggagugccag     2160

gaaucuugga aguga                                                      2175


<210>  3331
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RHOC__Homo_sapiens__P08134

<400>  3331

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Gln Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Arg Ser Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Ser Ala Phe Gly Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Gly Leu Gln Val Arg Lys Asn Lys Arg Arg Arg Gly Cys Pro Ile 
            180                 185                 190         


Leu 
    


<210>  3332
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RHOC__Homo_sapiens__AAC33179

<400>  3332
auggcugcaa uccgaaagaa gcuggugauc guuggggaug gugccugugg gaagaccugc       60

cuccucaucg ucuucagcaa ggaucaguuu ccggaggucu acgucccuac ugucuuugag      120

aacuauauug cggacauuga gguggacggc aagcaggugg agcuggcucu gugggacaca      180

gcagggcagg aagacuauga ucgacugcgg ccucucuccu acccggacac ugaugucauc      240

cucaugugcu ucuccaucga cagcccugac agccuggaaa acauuccuga gaaguggacc      300

ccagagguga agcacuucug ccccaacgug cccaucaucc ugguggggaa uaagaaggac      360

cugaggcaag acgagcacac caggagagag cuggccaaga ugaagcagga gcccguucgg      420

ucugaggaag gccgggacau ggcgaaccgg aucagugccu uuggcuaccu ugagugcuca      480

gccaagacca aggagggagu gcgggaggug uuugagaugg ccacucgggc uggccuccag      540

guccgcaaga acaagcgucg gaggggcugu cccauucucu ga                         582


<210>  3333
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RHOC__Homo_sapiens__AAC33179

<400>  3333
auggccgcca uccgcaagaa gcuggugauc gucggcgacg gggcgugcgg caagaccugc       60

cuccugaucg uguucagcaa ggaccaguuc cccgaggugu acgucccgac cguguucgag      120

aacuacaucg ccgacaucga gguggacggg aagcaggucg agcuggcccu cugggacacg      180

gccggccagg aggacuacga ccggcugcgc ccccuguccu accccgacac cgacgugauc      240

cucaugugcu ucagcaucga cucccccgac agccuggaga acaucccgga gaaguggacc      300

cccgagguga agcacuucug ccccaacguc cccaucaucc ugguggggaa caagaaggac      360

cuccggcagg acgagcacac ccgccgggag cuggccaaga ugaagcagga gccggugcgc      420

uccgaggagg gccgggacau ggcgaaccgc aucagcgccu ucggcuaccu ggagugcucc      480

gccaagacga aggagggggu ccgggaggug uucgagaugg ccacccgcgc gggccuccag      540

gugcggaaga acaagcgccg gcgcgggugc cccauccugu ga                         582


<210>  3334
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RHOC__Homo_sapiens__AAC33179

<400>  3334
auggccgcca uccgcaagaa gcucgucauc gucggcgacg gcgccugcgg caagaccugc       60

cuccucaucg ucuucuccaa ggaccaguuc cccgaggucu acguccccac cgucuucgag      120

aacuacaucg ccgacaucga ggucgacggc aagcaggucg agcucgcccu cugggacacc      180

gccggccagg aggacuacga ccgccuccgc ccccucuccu accccgacac cgacgucauc      240

cucaugugcu ucuccaucga cucccccgac ucccucgaga acauccccga gaaguggacc      300

cccgagguca agcacuucug ccccaacguc cccaucaucc ucgucggcaa caagaaggac      360

cuccgccagg acgagcacac ccgccgcgag cucgccaaga ugaagcagga gcccguccgc      420

uccgaggagg gccgcgacau ggccaaccgc aucuccgccu ucggcuaccu cgagugcucc      480

gccaagacca aggagggcgu ccgcgagguc uucgagaugg ccacccgcgc cggccuccag      540

guccgcaaga acaagcgccg ccgcggcugc cccauccucu ga                         582


<210>  3335
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RHOC__Homo_sapiens__AAC33179

<400>  3335
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggcaugcgg aaagaccugu       60

cuccuuauag uuuucagcaa agaucaguuu cccgaggugu acguaccuac aguguucgaa      120

aacuauaucg ccgacauuga ggucgauggu aagcaagugg aacuggcguu gugggacacu      180

gcuggccagg aggauuacga cagguuacgg ccacuguccu auccggauac ggacguuauc      240

cuaaugugcu uuucuauuga uucacccgac agucucgaaa auaucccuga gaaauggacc      300

ccagagguga agcacuucug ucccaacguc ccuauaaucc ugguggggaa uaagaaagau      360

cuucgccagg acgaacauac acgacgugag cuggccaaga ugaaacagga accaguaaga      420

agcgaggagg gaagggauau ggcaaaccgg auuuccgccu uuggcuacuu ggaaugcucu      480

gcuaagacua aagagggugu ucgcgaagug uucgagaugg caaccagagc cgggcuccaa      540

gucaggaaga auaagcggcg ccgaggaugu cccauccugu ga                         582


<210>  3336
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RHOC__Homo_sapiens__AAC33179

<400>  3336
auggccgcca ucagaaagaa gcuggugauc gugggcgacg gcgccugcgg caagaccugc       60

cugcugaucg uguucagcaa ggaccaguuc cccgaggugu acgugcccac cguguucgag      120

aacuacaucg ccgacaucga gguggacggc aagcaggugg agcuggcccu gugggacacc      180

gccggccagg aggacuacga cagacugaga ccccugagcu accccgacac cgacgugauc      240

cugaugugcu ucagcaucga cagccccgac agccuggaga acauccccga gaaguggacc      300

cccgagguga agcacuucug ccccaacgug cccaucaucc uggugggcaa caagaaggac      360

cugagacagg acgagcacac cagaagagag cuggccaaga ugaagcagga gcccgugaga      420

agcgaggagg gcagagacau ggccaacaga aucagcgccu ucggcuaccu ggagugcagc      480

gccaagacca aggagggcgu gagagaggug uucgagaugg ccaccagagc cggccugcag      540

gugagaaaga acaagagaag aagaggcugc cccauccugu ga                         582


<210>  3337
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RHOC__Homo_sapiens__AAC33179

<400>  3337
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggccugcgg aaagaccugu       60

cuccugaucg uuuucagcaa agaucaguuu cccgaggugu acgugccuac agucuucgaa      120

aacuauauug cggacaucga gguggauggc aagcaaguug aacuugcucu gugggacacg      180

gccgggcagg aggauuacga ccggcuccgc ccgcuguccu aucccgauac cgacgugauu      240

cuuaugugcu uuucuaucga uagcccugac ucccuggaaa auauccccga gaaauggaca      300

ccugagguca agcacuucug ucccaacgug ccuauuaucc ucguuggaaa uaagaaagau      360

cugagacagg acgaacauac ccggcgcgag cuggccaaga ugaaacagga accggugaga      420

ucugaggagg gccgggauau ggcuaaccgc auuagcgccu uuggguaccu cgaaugcucc      480

gcuaagacaa aagagggagu cagagaagug uucgagaugg ccacccgggc gggccugcaa      540

gugcgcaaga auaagagacg gcgcggcugu cccauccuuu ga                         582


<210>  3338
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RSSA__Homo_sapiens__P08865

<400>  3338

Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp 
                165                 170                 175     


Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255     


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala 
            260                 265                 270         


Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285             


Gly Ala Thr Thr Asp Trp Ser 
    290                 295 


<210>  3339
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RSSA__Homo_sapiens__AAA36161

<400>  3339
auguccggag cccuugaugu ccugcaaaug aaggaggagg auguccuuaa guuccuugca       60

gcaggaaccc acuuaggugg caccaaucuu gacuuccaga uggaacagua caucuauaaa      120

aggaaaagug auggcaucua uaucauaaau cucaagagga ccugggagaa gcuucugcug      180

gcagcucgug caauuguugc cauugaaaac ccugcugaug ucaguguuau auccuccagg      240

aauacuggcc agagggcugu gcugaaguuu gcugcugcca cuggagccac uccaauugcu      300

ggccgcuuca cuccuggaac cuucacuaac cagauccagg cagccuuccg ggagccacgg      360

cuucuugugg uuacugaccc cagggcugac caccagccuc ucacggaggc aucuuauguu      420

aaccuaccua ccauugcgcu guguaacaca gauucuccuc ugcgcuaugu ggacauugcc      480

aucccaugca acaacaaggg agcucacuca guggguuuga ugugguggau gcuggcucgg      540

gaaguucugc gcaugcgugg caccauuucc cgugaacacc caugggaggu caugccugau      600

cuguacuucu acagagaucc ugaagagauu gaaaaagaag agcaggcugc ugcugagaag      660

gcagugacca aggaggaauu ucagggugaa uggacugcuc ccgcuccuga guucacugcu      720

acucagccug agguugcaga cuggucugaa gguguacagg ugcccucugu gccuauucag      780

caauucccua cugaagacug gagcgcucag ccugccacgg aagacugguc ugcagcuccc      840

acugcucagg ccacugaaug gguaggagca accacugacu ggucuuaa                   888


<210>  3340
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RSSA__Homo_sapiens__AAA36161

<400>  3340
augagcggcg cccuggacgu gcuccagaug aaggaggagg acguccugaa guuccuggcc       60

gcggggaccc accucggcgg gaccaaccug gacuuccaga uggagcagua caucuacaag      120

cgcaaguccg acggcaucua caucaucaac cugaagcgga cgugggagaa gcuccugcug      180

gccgcccgcg ccaucguggc caucgagaac cccgcggacg ugagcgucau cuccagccgg      240

aacaccgggc agcgcgccgu gcucaaguuc gccgccgcga ccggcgccac cccgaucgcc      300

ggccgguuca cgcccgggac cuucaccaac cagauccagg ccgccuuccg cgagccccgg      360

cugcuggugg ucaccgaccc ccgcgcggac caccagccgc ucacggaggc cuccuacgug      420

aaccugccca ccaucgcccu gugcaacacc gacagccccc uccgguacgu ggacaucgcc      480

auccccugca acaacaaggg cgcccacucc gucgggcuga ugugguggau gcuggcgcgc      540

gaggugcucc ggaugcgcgg caccaucagc cgggagcacc cgugggaggu gaugcccgac      600

cuguacuucu accgcgaccc cgaggagauc gagaaggagg agcaggccgc cgccgagaag      660

gccgucacga aggaggaguu ccagggggag uggaccgcgc ccgccccgga guucaccgcc      720

acccagcccg agguggccga cugguccgag ggcgugcagg uccccagcgu gcccauccag      780

caguucccga cggaggacug guccgcccag cccgcgaccg aggacuggag cgccgccccc      840

accgcccagg cgaccgagug ggugggcgcc acgaccgacu gguccuga                   888


<210>  3341
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RSSA__Homo_sapiens__AAA36161

<400>  3341
auguccggcg cccucgacgu ccuccagaug aaggaggagg acguccucaa guuccucgcc       60

gccggcaccc accucggcgg caccaaccuc gacuuccaga uggagcagua caucuacaag      120

cgcaaguccg acggcaucua caucaucaac cucaagcgca ccugggagaa gcuccuccuc      180

gccgcccgcg ccaucgucgc caucgagaac cccgccgacg ucuccgucau cuccucccgc      240

aacaccggcc agcgcgccgu ccucaaguuc gccgccgcca ccggcgccac ccccaucgcc      300

ggccgcuuca cccccggcac cuucaccaac cagauccagg ccgccuuccg cgagccccgc      360

cuccucgucg ucaccgaccc ccgcgccgac caccagcccc ucaccgaggc cuccuacguc      420

aaccucccca ccaucgcccu cugcaacacc gacucccccc uccgcuacgu cgacaucgcc      480

auccccugca acaacaaggg cgcccacucc gucggccuca ugugguggau gcucgcccgc      540

gagguccucc gcaugcgcgg caccaucucc cgcgagcacc ccugggaggu caugcccgac      600

cucuacuucu accgcgaccc cgaggagauc gagaaggagg agcaggccgc cgccgagaag      660

gccgucacca aggaggaguu ccagggcgag uggaccgccc ccgcccccga guucaccgcc      720

acccagcccg aggucgccga cugguccgag ggcguccagg uccccuccgu ccccauccag      780

caguucccca ccgaggacug guccgcccag cccgccaccg aggacugguc cgccgccccc      840

accgcccagg ccaccgagug ggucggcgcc accaccgacu gguccuga                   888


<210>  3342
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RSSA__Homo_sapiens__AAA36161

<400>  3342
augagcggcg cccuggacgu gcuccagaug aaggaggaag auguccuuaa auuccuggcu       60

gcagggaccc acuugggagg uacaaacuua gacuuucaaa uggagcagua caucuauaag      120

agaaaauccg auggcauuua cauaaucaau cugaagagga cuugggaaaa acuacuccug      180

gccgcgcggg cuauuguugc caucgagaac cccgcagacg ugucuguaau uucaagucgc      240

aauacggggc agcgagccgu gcuuaaguuc gcugcagcca ccggagcuac accuaucgcc      300

ggccguuuua cuccagguac cuucacaaac cagauacaag cggcauuuag agaaccgagg      360

cuguuggucg ugaccgaucc ccgggccgac caucagccuc ucacugaggc uagcuauguu      420

aaucugccaa caaucgcccu gugcaacacc gauucucccc uccgcuacgu ggacauugca      480

aucccuugua auaacaaggg ggcucacucc gucggauuaa ugugguggau gcuggccaga      540

gaggugcuua ggaugcgggg cacgauuucg cgcgaacauc caugggaggu aaugcccgau      600

uuguauuucu accgagaccc ugaagagauc gagaaagagg aacaggcggc cgcagaaaag      660

gcuguuacua aagaggaauu ucagggcgag uggaccgccc cagcuccgga guucacagcc      720

acucaacccg aaguggcaga uuggucagag gggguccagg ugccuagcgu gccaauacag      780

caguuuccca ccgaagacug gagugcccaa ccugcuacag aggauugguc cgcggcacca      840

accgcccagg cuacggaaug ggucggagcc acuacagacu ggucuuga                   888


<210>  3343
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RSSA__Homo_sapiens__AAA36161

<400>  3343
augagcggcg cccuggacgu gcugcagaug aaggaggagg acgugcugaa guuccuggcc       60

gccggcaccc accugggcgg caccaaccug gacuuccaga uggagcagua caucuacaag      120

agaaagagcg acggcaucua caucaucaac cugaagagaa ccugggagaa gcugcugcug      180

gccgccagag ccaucguggc caucgagaac cccgccgacg ugagcgugau cagcagcaga      240

aacaccggcc agagagccgu gcugaaguuc gccgccgcca ccggcgccac ccccaucgcc      300

ggcagauuca cccccggcac cuucaccaac cagauccagg ccgccuucag agagcccaga      360

cugcuggugg ugaccgaccc cagagccgac caccagcccc ugaccgaggc cagcuacgug      420

aaccugccca ccaucgcccu gugcaacacc gacagccccc ugagauacgu ggacaucgcc      480

auccccugca acaacaaggg cgcccacagc gugggccuga ugugguggau gcuggccaga      540

gaggugcuga gaaugagagg caccaucagc agagagcacc ccugggaggu gaugcccgac      600

cuguacuucu acagagaccc cgaggagauc gagaaggagg agcaggccgc cgccgagaag      660

gccgugacca aggaggaguu ccagggcgag uggaccgccc ccgcccccga guucaccgcc      720

acccagcccg agguggccga cuggagcgag ggcgugcagg ugcccagcgu gcccauccag      780

caguucccca ccgaggacug gagcgcccag cccgccaccg aggacuggag cgccgccccc      840

accgcccagg ccaccgagug ggugggcgcc accaccgacu ggagcuga                   888


<210>  3344
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RSSA__Homo_sapiens__AAA36161

<400>  3344
augagcggcg cccuggacgu gcuccagaug aaggaggaag auguccugaa auuccuugcu       60

gccgggaccc accugggagg cacaaaccuc gacuuucaaa uggagcagua caucuauaag      120

agaaaauccg augggauuua caucauuaau cugaagcgga cgugggaaaa acuucugcuc      180

gcggcucgcg ccaucguugc cauugagaac cccgcugacg ugucugugau cagcuccaga      240

aauaccggac agcgggccgu ccugaaguuc gcugccgcga caggcgccac cccuaucgcu      300

gggcgcuuua caccgggaac cuucacaaac cagauucaag ccgcuuuuag agaaccccgg      360

cugcucgugg uuaccgaucc ucgcgccgac caucagcccc ugacggaggc gucuuaugug      420

aaucuuccua ccaucgcccu gugcaacaca gauagccccc ucagauacgu cgacauugcu      480

aucccuugua auaacaaggg cgcccacucc gugggccuga ugugguggau gcuugcucgg      540

gagguucugc gcaugagagg gaccauuucu cgggaacauc cgugggaggu gaugcccgau      600

cucuauuucu accgcgaccc ugaagagauc gagaaagagg aacaggccgc cgcugaaaag      660

gcggucacaa aagaggaauu ucagggagag uggaccgccc ccgcuccuga guucacggcc      720

acacaacccg aaguggccga uuggagcgag ggcgugcagg ucccguccgu uccuauucag      780

caguuuccca ccgaagacug gagcgcucaa ccugccacag aggauugguc ugcggcuccc      840

accgcccagg ccaccgaaug ggugggggcu acaacggacu gguccuga                   888


<210>  3345
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RU1__Homo_sapiens__Q9UHJ3

<400>  3345

Met Asn Gly Glu Gln Gln Leu Asp Ala Asp Ala Gly Ser Gly Met Glu 
1               5                   10                  15      


Glu Val Glu Leu Ser Trp Glu Asp Tyr Leu Glu Glu Thr Gly Ser Thr 
            20                  25                  30          


Ala Val Pro Tyr Gly Ser Phe Lys His Val Asp Thr Arg Leu Gln Asn 
        35                  40                  45              


Gly Phe Ala Pro Gly Met Lys Leu Glu Val Ala Val Arg Thr Asp Pro 
    50                  55                  60                  


Glu Thr Tyr Trp Val Ala Thr Val Ile Thr Thr Cys Glu Gln Leu Leu 
65                  70                  75                  80  


Leu Leu Arg Tyr Asp Gly Tyr Gly Glu Asp Arg Arg Ala Asp Phe Trp 
                85                  90                  95      


Cys Asp Ile Arg Lys Ala Asp Leu Tyr Pro Ile Gly Trp Cys Glu Gln 
            100                 105                 110         


Asn Lys Lys Thr Leu Glu Ala Pro Glu Gly Ile Arg Asp Lys Val Ser 
        115                 120                 125             


Asp Trp Asp Glu Phe Leu Arg Gln Thr Leu Ile Gly Ala Cys Ser Pro 
    130                 135                 140                 


Pro Val Pro Leu Leu Glu Gly Leu Arg Asn Gly Arg Asn Pro Leu Asp 
145                 150                 155                 160 


Leu Ile Ala Pro Gly Ser Arg Leu Glu Cys Gln Ala Phe Gln Asp Ser 
                165                 170                 175     


Leu Ser Thr Trp Ile Val Thr Val Val Glu Asn Ile Gly Gly Arg Leu 
            180                 185                 190         


Lys Leu Arg Tyr Glu Gly Leu Glu Ser Ser Asp Asn Tyr Glu His Trp 
        195                 200                 205             


Leu Tyr Tyr Leu Asp Pro Phe Leu His His Val Gly Trp Ala Ala Gln 
    210                 215                 220                 


Gln Gly Tyr Glu Leu Gln Pro Pro Ser Ala Ile Arg His Leu Lys Asn 
225                 230                 235                 240 


Glu Ala Glu Trp Gln Glu Ile Leu Ala Lys Val Lys Glu Glu Glu Glu 
                245                 250                 255     


Glu Pro Leu Pro Ser Tyr Leu Phe Lys Asp Lys Gln Val Ile Gly Ile 
            260                 265                 270         


His Thr Phe Ser Val Asn Met Lys Leu Glu Ala Val Asp Pro Trp Ser 
        275                 280                 285             


Pro Phe Gly Ile Ser Pro Ala Thr Val Val Lys Val Phe Asp Glu Lys 
    290                 295                 300                 


Tyr Phe Leu Val Glu Met Asp Asp Leu Arg Pro Glu Asn His Ala Arg 
305                 310                 315                 320 


Arg Ser Phe Val Cys His Ala Asp Ser Pro Gly Ile Phe Pro Val Gln 
                325                 330                 335     


Trp Ser Leu Lys Asn Gly Leu His Ile Ser Pro Pro Pro Gly Tyr Pro 
            340                 345                 350         


Ser Gln Asp Phe Asp Trp Ala Asp Tyr Leu Lys Gln Cys Gly Ala Glu 
        355                 360                 365             


Ala Ala Pro Gln Arg Cys Phe Pro Pro Leu Ile Ser Glu His Glu Phe 
    370                 375                 380                 


Lys Glu Asn Met Lys Leu Glu Ala Val Asn Pro Ile Leu Pro Glu Glu 
385                 390                 395                 400 


Val Cys Val Ala Thr Ile Thr Ala Val Arg Gly Ser Tyr Leu Trp Leu 
                405                 410                 415     


Gln Leu Glu Gly Ser Lys Lys Pro Ile Pro Glu Cys Ile Val Ser Val 
            420                 425                 430         


Glu Ser Met Asp Ile Phe Pro Leu Gly Trp Cys Glu Thr Asn Gly His 
        435                 440                 445             


Pro Leu Ser Thr Pro Arg Arg Ala Arg Val Tyr Lys Gln Arg Lys Ile 
    450                 455                 460                 


Ala Val Val Gln Pro Glu Lys Gln Val Pro Ser Ser Arg Thr Val His 
465                 470                 475                 480 


Glu Gly Leu Arg Asn Gln Glu Leu Asn Ser Thr Glu Ser Val Met Ile 
                485                 490                 495     


Asn Gly Lys Tyr Cys Cys Pro Lys Ile Tyr Phe Asn His Arg Cys Phe 
            500                 505                 510         


Ser Gly Pro Tyr Leu Asn Lys Gly Arg Ile Ala Glu Leu Pro Gln Cys 
        515                 520                 525             


Val Gly Pro Gly Asn Cys Val Leu Val Leu Arg Glu Val Leu Thr Leu 
    530                 535                 540                 


Leu Ile Asn Ala Ala Tyr Lys Pro Ser Arg Val Leu Arg Glu Leu Gln 
545                 550                 555                 560 


Leu Asp Lys Asp Ser Val Trp His Gly Cys Gly Glu Val Leu Lys Ala 
                565                 570                 575     


Lys Tyr Lys Gly Lys Ser Tyr Arg Ala Thr Val Glu Ile Val Lys Thr 
            580                 585                 590         


Ala Asp Arg Val Thr Glu Phe Cys Arg Gln Thr Cys Ile Lys Leu Glu 
        595                 600                 605             


Cys Cys Pro Asn Leu Phe Gly Pro Arg Met Val Leu Asp Lys Cys Ser 
    610                 615                 620                 


Glu Asn Cys Ser Val Leu Thr Lys Thr Lys Tyr Thr His Tyr Tyr Gly 
625                 630                 635                 640 


Lys Lys Lys Asn Lys Arg Ile Gly Arg Pro Pro Gly Gly His Ser Asn 
                645                 650                 655     


Leu Ala Cys Ala Leu Lys Lys Ala Ser Lys Arg Arg Lys Arg Arg Lys 
            660                 665                 670         


Asn Val Phe Val His Lys Lys Lys Arg Ser Ser Ala Ser Val Asp Asn 
        675                 680                 685             


Thr Pro Ala Gly Ser Pro Gln Gly Ser Gly Gly Glu Asp Glu Asp Asp 
    690                 695                 700                 


Pro Asp Glu Gly Asp Asp Asp Ser Leu Ser Glu Gly Ser Thr Ser Glu 
705                 710                 715                 720 


Gln Gln Asp Glu Leu Gln Glu Glu Ser Glu Met Ser Glu Lys Lys Ser 
                725                 730                 735     


Cys Ser Ser Ser Pro Thr Gln Ser Glu Ile Ser Thr Ser Leu Pro Pro 
            740                 745                 750         


Asp Arg Gln Arg Arg Lys Arg Glu Leu Arg Thr Phe Ser Phe Ser Asp 
        755                 760                 765             


Asp Glu Asn Lys Pro Pro Ser Pro Lys Glu Ile Arg Ile Glu Val Ala 
    770                 775                 780                 


Glu Arg Leu His Leu Asp Ser Asn Pro Leu Lys Trp Ser Val Ala Asp 
785                 790                 795                 800 


Val Val Arg Phe Ile Arg Ser Thr Asp Cys Ala Pro Leu Ala Arg Ile 
                805                 810                 815     


Phe Leu Asp Gln Glu Ile Asp Gly Gln Ala Leu Leu Leu Leu Thr Leu 
            820                 825                 830         


Pro Thr Val Gln Glu Cys Met Asp Leu Lys Leu Gly Pro Ala Ile Lys 
        835                 840                 845             


Leu Cys His His Ile Glu Arg Ile Lys Phe Ala Phe Tyr Glu Gln Phe 
    850                 855                 860                 


Ala Asn 
865     


<210>  3346
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RU1__Homo_sapiens__AAH14614

<400>  3346
augaacgggg agcagcagcu ugaugcagau gccggcucug guauggaaga gguagaauua       60

agcugggaag auuaucuaga agaaacaggg uccacagcag uucccuaugg gucuuuuaaa      120

cauguggaca cacgucugca aaauggauuu gcuccuggga ugaagcugga gguggcugug      180

agaacagauc cugagaccua cuggguugcc accguuauca cuaccuguga gcaguugcuc      240

cuucuccgcu augauggcua uggggaggau cggagagcag auuucuggug ugacaucagg      300

aaggcugauc ucuaccccau uggguggugu gagcagaaua agaagacccu ugaagcccca      360

gaaggcauca gagauaaagu aucugacugg gaugaguuuc ugcggcagac ccugauagga      420

gcauguaguc cuccuguucc gcugcuagag ggccuccgua augggaggaa uccuuuagau      480

cucauugcuc caggauccag acuagaaugu caagcuuucc aggacucuuu aagcacuugg      540

auuguuacug uaguagaaaa cauuggagga aggcugaagc uacguuauga aggacuugaa      600

aguucugaca auuaugaaca uugguuguau uacuuggauc cauuucuuca ucacguuggu      660

ugggcugcuc aacagggaua ugagcuucag cccccuucag ccauuagaca ucuaaaaaau      720

gaagcugagu ggcaagagau uuuggccaaa gugaaagagg aagaggaaga gccauuacca      780

ucuuacuuau uuaaggacaa acaaguuauu ggcauucaua cauucucugu aaacaugaaa      840

uuggaagcug uagaccccug gucuccuuuu gggaucucuc cugcuacagu uguuaagguu      900

uuugaugaga aguacuuucu gguggaaaug gaugacuugc guccugagaa ccacgcacgg      960

cgauccuuug ugugccacgc cgacaguccu ggcaucuucc cugugcagug gagucugaag     1020

aauggccuac acaucagccc cccuccaggc uacccaagcc aggacuuuga cugggcugac     1080

uaccucaaac aguguggugc ugaagcugcu ccccagaggu gcuucccucc guuaauuucu     1140

gaacaugaau uuaaggagaa caugaagcuc gaggcgguga accccauucu cccugaagaa     1200

guguguguug cuaccaucac ugcagugaga ggcuccuacc uguggcucca gcuggagggu     1260

ucuaagaagc cuauaccuga auguauugug aguguggaau ccauggauau auuuccuuug     1320

ggcuggugug aaaccaacgg ccacccccuc agcacuccuc gccgagcacg aguauauaaa     1380

cagaggaaaa uugcaguggu ucagccagaa aaacaaguac cauccucgag gacuguccac     1440

gagggccuga ggaaucagga gcugaacucc acagagucag uuaugauuaa uggaaaauau     1500

ugcuguccaa agauauacuu caaccaccgu ugcuucucag ggccauaucu uaacaaagga     1560

agaauugcug agcugccuca auguguagga ccugggaacu guguucuggu ccuuagagag     1620

guccucacuu uacuuaucaa ugcagccuac aaacccagcc guguccuucg ggagcuccag     1680

cuggacaaag acucugugug gcacggaugu ggggaagucc uaaaagccaa auauaaagga     1740

aagaguuauc gggcuacugu ugagauagug aaaacagcag aucgggugac ugaauucugc     1800

cggcaaaccu guaucaaacu ggaaugcugu ccuaaccucu ucgguccacg gaugguucug     1860

gauaaguguu cugagaacug uucuguacuu acaaagacca aauacacaca cuauuacgga     1920

aagaagaaaa auaaaagaau ugggaggcca ccuggugggc auaguaacuu agcuugugcc     1980

cugaaaaaag ccaguaagag gagaaagagg cggaaaaaug uuuuuguuca uaagaagaaa     2040

cgcuccucug caucuguuga uaauacccca gcgggcucuc cccagggaag ugggggugaa     2100

gaugaggaug acccagauga aggggaugau gauucccuaa gugaaggcag uacauccgag     2160

cagcaggaug agcuacagga agaaucagaa augucagaaa aaaagucaug cuccucuucu     2220

cccacccaaa gugagauauc cacaucgcug ccuccagaua gacaaaggag aaaaagggag     2280

cuucgcaccu uuucauuuuc ugacgaugaa aauaaaccuc cuucaccaaa ggaaauaagg     2340

aucgaaguug cugaaaggcu ucaccuggac aguaaccccu ugaaguggag uguggcagac     2400

guugugcggu ucaucagauc cacugacugu gcuccauuag caagaauauu ccuagaccag     2460

gaaauugaug ggcaggcccu guugcuccuu acccuuccca cuguucaaga augcauggac     2520

uuaaaauugg gcccugccau caaacuuugc caucacauag agaggaucaa guuugcuuuu     2580

uaugagcagu uugccaacug a                                               2601


<210>  3347
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RU1__Homo_sapiens__AAH14614

<400>  3347
augaacggcg agcagcagcu ggacgccgac gccgggagcg gcauggagga gguggagcuc       60

uccugggagg acuaccugga ggagaccggg agcaccgcgg uccccuacgg cuccuucaag      120

cacguggaca cgcgccugca gaacggguuc gccccgggca ugaagcucga gguggccguc      180

cggaccgacc ccgagaccua cuggguggcc accgugauca cgaccugcga gcagcugcug      240

cuccugcgcu acgacggcua cggggaggac cggcgcgccg acuucuggug cgacauccgg      300

aaggcggacc uguaccccau cggcuggugc gagcagaaca agaagacccu cgaggccccc      360

gaggggaucc gcgacaaggu cagcgacugg gacgaguucc ugcggcagac ccugaucggc      420

gccugcuccc cgcccgugcc ccuccuggag gggcugcgca acggccggaa cccccucgac      480

cugaucgccc cgggcagccg ccuggagugc caggcguucc aggacucccu cagcacgugg      540

aucgugaccg ucguggagaa caucgggggc cggcugaagc ugcgcuacga ggggcucgag      600

uccagcgaca acuacgagca cuggcuguac uaccuggacc ccuuccucca ccacgugggc      660

ugggccgccc agcagggcua cgagcugcag ccgcccuccg ccauccggca ccugaagaac      720

gaggccgagu ggcaggagau ccucgcgaag gucaaggagg aggaggagga gccccugccc      780

agcuaccugu ucaaggacaa gcaggucauc gggauccaca ccuucuccgu gaacaugaag      840

cucgaggccg uggaccccug gagccccuuc ggcaucuccc cggccaccgu ggugaagguc      900

uucgacgaga aguacuuccu gguggagaug gacgaccugc gccccgagaa ccacgcccgg      960

cgcagcuucg ugugccacgc cgacuccccc gggaucuucc ccguccagug gagccucaag     1020

aacggccugc acaucucccc gccgcccggg uaccccagcc aggacuucga cugggcggac     1080

uaccugaagc agugcggcgc cgaggccgcg ccccagcggu gcuucccgcc ccucaucagc     1140

gagcacgagu ucaaggagaa caugaagcug gaggccguga accccauccu gcccgaggag     1200

gugugcgucg ccacgaucac cgccgugcgc ggcuccuacc ucuggcugca gcuggagggg     1260

agcaagaagc ccauccccga gugcaucguc uccguggaga gcauggacau cuucccgcuc     1320

ggcuggugcg agaccaacgg gcacccccug uccacgcccc ggcgcgcccg gguguacaag     1380

cagcgcaaga ucgccgucgu gcagcccgag aagcaggucc cgagcucccg caccgugcac     1440

gagggccugc ggaaccagga gcucaacagc accgaguccg ugaugaucaa cgggaaguac     1500

ugcugcccca agaucuacuu caaccaccgc ugcuucagcg gccccuaccu gaacaagggc     1560

cggaucgccg agcugcccca gugcgugggg ccgggcaacu gcguccucgu gcugcgcgag     1620

gugcugaccc ugcucaucaa cgcggccuac aagcccuccc ggguccugcg cgagcugcag     1680

cucgacaagg acagcgugug gcacgggugc ggcgaggugc ugaaggccaa guacaagggg     1740

aaguccuacc gggccaccgu cgagaucgug aagacggcgg accgcgugac cgaguucugc     1800

cggcagaccu gcaucaagcu ggagugcugc cccaaccucu ucggcccccg caugguccug     1860

gacaagugca gcgagaacug cuccgugcug accaagacga aguacaccca cuacuacggc     1920

aagaagaaga acaagcggau cgggcgcccg cccggcgggc acagcaaccu cgccugcgcc     1980

cugaagaagg ccuccaagcg gcgcaagcgg cgcaagaacg uguucgucca caagaagaag     2040

cggagcuccg ccagcgugga caacaccccc gcgggcagcc cccagggcuc cgggggcgag     2100

gacgaggacg acccggacga gggggacgac gacagccugu ccgagggcag caccuccgag     2160

cagcaggacg agcuccagga ggagagcgag auguccgaga agaaguccug cagcagcucc     2220

cccacgcaga gcgagaucuc caccagccug ccgcccgacc gccagcggcg caagcgcgag     2280

cugcggaccu ucuccuucag cgacgacgag aacaagccgc ccucccccaa ggagauccgc     2340

aucgaggugg ccgagcggcu ccaccuggac agcaaccccc ugaaguggag cgucgccgac     2400

guggugcgcu ucauccgguc caccgacugc gcgccccucg cccgcaucuu ccuggaccag     2460

gagaucgacg ggcaggcccu gcuccugcug acgcucccca ccguccagga gugcauggac     2520

cugaagcugg gccccgccau caagcucugc caccacaucg agcggaucaa guucgccuuc     2580

uacgagcagu ucgccaacug a                                               2601


<210>  3348
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RU1__Homo_sapiens__AAH14614

<400>  3348
augaacggcg agcagcagcu cgacgccgac gccggcuccg gcauggagga ggucgagcuc       60

uccugggagg acuaccucga ggagaccggc uccaccgccg uccccuacgg cuccuucaag      120

cacgucgaca cccgccucca gaacggcuuc gcccccggca ugaagcucga ggucgccguc      180

cgcaccgacc ccgagaccua cugggucgcc accgucauca ccaccugcga gcagcuccuc      240

cuccuccgcu acgacggcua cggcgaggac cgccgcgccg acuucuggug cgacauccgc      300

aaggccgacc ucuaccccau cggcuggugc gagcagaaca agaagacccu cgaggccccc      360

gagggcaucc gcgacaaggu cuccgacugg gacgaguucc uccgccagac ccucaucggc      420

gccugcuccc cccccguccc ccuccucgag ggccuccgca acggccgcaa cccccucgac      480

cucaucgccc ccggcucccg ccucgagugc caggccuucc aggacucccu cuccaccugg      540

aucgucaccg ucgucgagaa caucggcggc cgccucaagc uccgcuacga gggccucgag      600

uccuccgaca acuacgagca cuggcucuac uaccucgacc ccuuccucca ccacgucggc      660

ugggccgccc agcagggcua cgagcuccag ccccccuccg ccauccgcca ccucaagaac      720

gaggccgagu ggcaggagau ccucgccaag gucaaggagg aggaggagga gccccucccc      780

uccuaccucu ucaaggacaa gcaggucauc ggcauccaca ccuucuccgu caacaugaag      840

cucgaggccg ucgaccccug gucccccuuc ggcaucuccc ccgccaccgu cgucaagguc      900

uucgacgaga aguacuuccu cgucgagaug gacgaccucc gccccgagaa ccacgcccgc      960

cgcuccuucg ucugccacgc cgacuccccc ggcaucuucc ccguccagug gucccucaag     1020

aacggccucc acaucucccc cccccccggc uaccccuccc aggacuucga cugggccgac     1080

uaccucaagc agugcggcgc cgaggccgcc ccccagcgcu gcuucccccc ccucaucucc     1140

gagcacgagu ucaaggagaa caugaagcuc gaggccguca accccauccu ccccgaggag     1200

gucugcgucg ccaccaucac cgccguccgc ggcuccuacc ucuggcucca gcucgagggc     1260

uccaagaagc ccauccccga gugcaucguc uccgucgagu ccauggacau cuucccccuc     1320

ggcuggugcg agaccaacgg ccacccccuc uccacccccc gccgcgcccg cgucuacaag     1380

cagcgcaaga ucgccgucgu ccagcccgag aagcaggucc ccuccucccg caccguccac     1440

gagggccucc gcaaccagga gcucaacucc accgaguccg ucaugaucaa cggcaaguac     1500

ugcugcccca agaucuacuu caaccaccgc ugcuucuccg gccccuaccu caacaagggc     1560

cgcaucgccg agcuccccca gugcgucggc cccggcaacu gcguccucgu ccuccgcgag     1620

guccucaccc uccucaucaa cgccgccuac aagcccuccc gcguccuccg cgagcuccag     1680

cucgacaagg acuccgucug gcacggcugc ggcgaggucc ucaaggccaa guacaagggc     1740

aaguccuacc gcgccaccgu cgagaucguc aagaccgccg accgcgucac cgaguucugc     1800

cgccagaccu gcaucaagcu cgagugcugc cccaaccucu ucggcccccg caugguccuc     1860

gacaagugcu ccgagaacug cuccguccuc accaagacca aguacaccca cuacuacggc     1920

aagaagaaga acaagcgcau cggccgcccc cccggcggcc acuccaaccu cgccugcgcc     1980

cucaagaagg ccuccaagcg ccgcaagcgc cgcaagaacg ucuucgucca caagaagaag     2040

cgcuccuccg ccuccgucga caacaccccc gccggcuccc cccagggcuc cggcggcgag     2100

gacgaggacg accccgacga gggcgacgac gacucccucu ccgagggcuc caccuccgag     2160

cagcaggacg agcuccagga ggaguccgag auguccgaga agaaguccug cuccuccucc     2220

cccacccagu ccgagaucuc caccucccuc ccccccgacc gccagcgccg caagcgcgag     2280

cuccgcaccu ucuccuucuc cgacgacgag aacaagcccc ccucccccaa ggagauccgc     2340

aucgaggucg ccgagcgccu ccaccucgac uccaaccccc ucaagugguc cgucgccgac     2400

gucguccgcu ucauccgcuc caccgacugc gccccccucg cccgcaucuu ccucgaccag     2460

gagaucgacg gccaggcccu ccuccuccuc acccucccca ccguccagga gugcauggac     2520

cucaagcucg gccccgccau caagcucugc caccacaucg agcgcaucaa guucgccuuc     2580

uacgagcagu ucgccaacug a                                               2601


<210>  3349
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RU1__Homo_sapiens__AAH14614

<400>  3349
augaacggcg agcagcaacu ggacgccgau gcugggagcg gaauggaaga gguggaacuc       60

uccugggagg acuaccuuga agagaccggu ucuacagcag uccccuaugg cucauucaag      120

cacguugaua cuagacugca gaauggguuu gccccuggaa ugaaauugga gguggcggua      180

aggacggacc cagaaaccua cuggguggcu acagucauca cuaccugcga gcaguuacug      240

cuacuccggu augauggcua cggugaagac cgccgagccg auuucuggug ugacauucgu      300

aaggcagauc uguauccgau aggguggugc gagcagaaca aaaagacacu ugaggccccc      360

gaaggaauca gagacaaagu gagugauugg gacgaguuuc ugaggcaaac cuugauuggc      420

gcuuguagcc cuccaguucc ccuccuggaa ggccugcgga augggcgcaa cccucucgau      480

uuaaucgcac caggauccag acuggagugc caggccuucc aggacucucu uucgacuugg      540

auugugacag ucguggaaaa uaucgguggc agguugaagc ugcgguacga ggggcuagag      600

ucaagcgaca acuaugaaca uuggcucuac uaccuggauc ccuuucuuca ccauguagga      660

ugggcugccc agcaaggcua ugagcugcag ccuccaagug cgauacgcca cuugaagaau      720

gaagcagagu ggcaggaaau ccucgccaaa guuaaggagg aggaagagga accgcugccc      780

uccuacuuau ucaaagacaa acaggugauu gguauccaua ccuuuucugu caacaugaag      840

cuggaggcug uggauccuug gagcccauuc gggauuuccc ccgccacggu ggucaagguu      900

uuugacgaaa aguauuuccu cguggagaug gaugaccuuc gaccugagaa ucacgcaaga      960

aggucauuug uaugucacgc ugauagucca ggaaucuucc ccgugcaaug gagccugaaa     1020

aacggcuugc auauaucucc gccucccggc uacccauccc aggacuuuga uugggccgac     1080

uaucuaaagc agugcggggc ggaagccgca ccucaacggu guuuuccccc acugauuuca     1140

gagcacgagu ucaaagaaaa uaugaagcuc gaggcuguca accccauccu gccugaagag     1200

gugugcguug ccacuauuac cgcugugcgu ggaagcuacc uuuggcugca guuggaaggu     1260

aguaaaaagc caaucccgga guguaucguc ucuguggaau ccauggauau uuucccccuc     1320

ggcuggugcg agacaaaugg gcauccucug agcacuccac gcagagccag gguauauaaa     1380

cagcggaaga uagcaguugu gcagcccgag aagcaagucc cuucgucucg aaccgugcac     1440

gaaggauuac gcaaccagga gcuuaauucc acagaaucag ucaugaucaa cggcaaauac     1500

uguugcccaa agauuuacuu caaccacaga ugcuuuagug gucccuaucu aaauaaaggg     1560

aggaucgccg agcucccgca gugugugggc ccuggaaacu gcguucuggu gcuucgggaa     1620

guauugaccc ugcucauaaa ugcugcguac aagccaagcc gcguccugag agagcuucag     1680

cuggacaaag acuccgugug gcauggcugu ggggagguuu ugaaggcaaa guauaaagga     1740

aagucuuaca gggccacggu ggaaauuguc aaaacugcug aucgugugac agaguucugc     1800

cggcaaaccu guaucaagcu cgaaugcugu cccaaccugu uugguccucg aaugguauua     1860

gacaaaugca gcgagaauug uucagugcug acuaagacaa aguauaccca cuacuauggc     1920

aaaaagaaaa acaagagaau cgggaggccc ccaggaggcc auaguaaucu agccugcgca     1980

cucaaaaagg ccuccaagcg ccggaaaaga aggaagaacg uuuucgucca caaaaagaaa     2040

cgcagcucug cuucagugga uaauacgccu gccgguaguc cccaggggag cggcggagaa     2100

gacgaggaug acccagauga gggcgacgau gacucccugu cugaaggguc gaccagcgag     2160

cagcaggaug aacuucaaga ggaguccgaa augucagaga agaaaaguug uucuagcucc     2220

ccgacacagu cagaaauuag cacuucuuug ccucccgacc gacagcggcg uaagagagag     2280

cugaggaccu uuuccuucag ugaugacgaa aacaagccac ccagcccuaa agagauccgc     2340

auugaggugg cagaacggcu ccaucuggac ucuaauccau uaaagugguc cgucgcggau     2400

guugugagau uuauaagguc aacagacugc gcuccccugg cccgaaucuu ccuugaucag     2460

gagauugacg gacaagcauu gcuccugcua acucugccua ccgugcagga augcauggau     2520

cucaaacugg guccggccau caagcugugu caccacaucg agcgcauuaa auuugcuuuc     2580

uacgaacagu uugccaacug a                                               2601


<210>  3350
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RU1__Homo_sapiens__AAH14614

<400>  3350
augaacggcg agcagcagcu ggacgccgac gccggcagcg gcauggagga gguggagcug       60

agcugggagg acuaccugga ggagaccggc agcaccgccg ugcccuacgg cagcuucaag      120

cacguggaca ccagacugca gaacggcuuc gcccccggca ugaagcugga gguggccgug      180

agaaccgacc ccgagaccua cuggguggcc accgugauca ccaccugcga gcagcugcug      240

cugcugagau acgacggcua cggcgaggac agaagagccg acuucuggug cgacaucaga      300

aaggccgacc uguaccccau cggcuggugc gagcagaaca agaagacccu ggaggccccc      360

gagggcauca gagacaaggu gagcgacugg gacgaguucc ugagacagac ccugaucggc      420

gccugcagcc cccccgugcc ccugcuggag ggccugagaa acggcagaaa cccccuggac      480

cugaucgccc ccggcagcag acuggagugc caggccuucc aggacagccu gagcaccugg      540

aucgugaccg ugguggagaa caucggcggc agacugaagc ugagauacga gggccuggag      600

agcagcgaca acuacgagca cuggcuguac uaccuggacc ccuuccugca ccacgugggc      660

ugggccgccc agcagggcua cgagcugcag ccccccagcg ccaucagaca ccugaagaac      720

gaggccgagu ggcaggagau ccuggccaag gugaaggagg aggaggagga gccccugccc      780

agcuaccugu ucaaggacaa gcaggugauc ggcauccaca ccuucagcgu gaacaugaag      840

cuggaggccg uggaccccug gagccccuuc ggcaucagcc ccgccaccgu ggugaaggug      900

uucgacgaga aguacuuccu gguggagaug gacgaccuga gacccgagaa ccacgccaga      960

agaagcuucg ugugccacgc cgacagcccc ggcaucuucc ccgugcagug gagccugaag     1020

aacggccugc acaucagccc cccccccggc uaccccagcc aggacuucga cugggccgac     1080

uaccugaagc agugcggcgc cgaggccgcc ccccagagau gcuucccccc ccugaucagc     1140

gagcacgagu ucaaggagaa caugaagcug gaggccguga accccauccu gcccgaggag     1200

gugugcgugg ccaccaucac cgccgugaga ggcagcuacc uguggcugca gcuggagggc     1260

agcaagaagc ccauccccga gugcaucgug agcguggaga gcauggacau cuucccccug     1320

ggcuggugcg agaccaacgg ccacccccug agcaccccca gaagagccag aguguacaag     1380

cagagaaaga ucgccguggu gcagcccgag aagcaggugc ccagcagcag aaccgugcac     1440

gagggccuga gaaaccagga gcugaacagc accgagagcg ugaugaucaa cggcaaguac     1500

ugcugcccca agaucuacuu caaccacaga ugcuucagcg gccccuaccu gaacaagggc     1560

agaaucgccg agcugcccca gugcgugggc cccggcaacu gcgugcuggu gcugagagag     1620

gugcugaccc ugcugaucaa cgccgccuac aagcccagca gagugcugag agagcugcag     1680

cuggacaagg acagcgugug gcacggcugc ggcgaggugc ugaaggccaa guacaagggc     1740

aagagcuaca gagccaccgu ggagaucgug aagaccgccg acagagugac cgaguucugc     1800

agacagaccu gcaucaagcu ggagugcugc cccaaccugu ucggccccag aauggugcug     1860

gacaagugca gcgagaacug cagcgugcug accaagacca aguacaccca cuacuacggc     1920

aagaagaaga acaagagaau cggcagaccc cccggcggcc acagcaaccu ggccugcgcc     1980

cugaagaagg ccagcaagag aagaaagaga agaaagaacg uguucgugca caagaagaag     2040

agaagcagcg ccagcgugga caacaccccc gccggcagcc cccagggcag cggcggcgag     2100

gacgaggacg accccgacga gggcgacgac gacagccuga gcgagggcag caccagcgag     2160

cagcaggacg agcugcagga ggagagcgag augagcgaga agaagagcug cagcagcagc     2220

cccacccaga gcgagaucag caccagccug ccccccgaca gacagagaag aaagagagag     2280

cugagaaccu ucagcuucag cgacgacgag aacaagcccc ccagccccaa ggagaucaga     2340

aucgaggugg ccgagagacu gcaccuggac agcaaccccc ugaaguggag cguggccgac     2400

guggugagau ucaucagaag caccgacugc gccccccugg ccagaaucuu ccuggaccag     2460

gagaucgacg gccaggcccu gcugcugcug acccugccca ccgugcagga gugcauggac     2520

cugaagcugg gccccgccau caagcugugc caccacaucg agagaaucaa guucgccuuc     2580

uacgagcagu ucgccaacug a                                               2601


<210>  3351
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RU1__Homo_sapiens__AAH14614

<400>  3351
augaacggcg agcagcaacu ggacgccgau gcugggagcg gaauggaaga gguggaacuc       60

uccugggagg acuaccugga agagaccggc ucuacagccg uccccuaugg gagcuucaag      120

cacguugaua cgagacuuca gaauggauuu gcgccuggca ugaaacugga gguggcugug      180

cggaccgacc cggaaacaua cugggucgcc accgugauca caaccugcga gcagcuccug      240

cuucugcgcu augaugggua cggagaagac agacgggccg auuucuggug ugacauucgc      300

aaggcugauc ucuaucccau cggcuggugc gagcagaaca aaaagacacu ggaggccccu      360

gaaggcauua gagacaaagu uuccgauugg gacgaguuuc ugcggcaaac ccucaucggg      420

gcuuguucuc ccccugugcc ccugcuugaa ggacugcgca auggcagaaa cccucucgau      480

cugauugccc cggggagccg gcuugagugc caggcguucc aggacucccu gucuacgugg      540

aucgucaccg ugguugaaaa uaucggaggc cgccucaagc ugagauacga ggggcuggag      600

agcuccgaca acuaugaaca uuggcucuac uaccuggauc ccuuucuuca ccauguggga      660

ugggccgcuc agcaaggcua ugagcugcag ccucccagcg ccauucggca ccucaagaau      720

gaagcugagu ggcaggaaau ccuggccaaa gucaaggagg aggaagagga accucuuccc      780

ucuuaccugu ucaaagacaa acaggugauu ggcauccaua cauuuuccgu gaacaugaag      840

cucgaggcgg ucgauccgug gagcccuuuc gggauuucuc ccgccaccgu ugugaaggug      900

uuugacgaaa aguauuuccu ggucgagaug gaugaccugc gcccugagaa ucacgcuaga      960

cgguccuuug ugugucacgc cgauagcccc ggaaucuucc ccguucaaug gucucucaaa     1020

aacggccugc auauuucccc uccgcccggg uacccuagcc aggacuuuga uugggcugac     1080

uaucuuaagc agugcggagc cgaagccgcu ccccaacgcu guuucccucc ccugaucucc     1140

gagcacgagu ucaaagaaaa uaugaagcuc gaggcgguga acccgauccu gccugaagag     1200

gucugcgugg ccacaauuac cgcuguuaga ggcucuuacc uuuggcugca gcucgaaggg     1260

agcaaaaagc ccaucccuga guguauugug uccgucgaaa gcauggauau cuuuccccug     1320

ggauggugcg agacgaaugg ccauccucug ucuacacccc ggagagcccg cguguauaaa     1380

cagcggaaga uugccgucgu gcagccggag aagcaaguuc cuuccagcag aaccgugcac     1440

gaaggccucc gcaaccagga gcuuaauucu acagaaagcg ucaugaucaa cgggaaauac     1500

uguugcccca agaucuacuu caaccaccgg ugcuuuuccg gacccuaucu uaauaaaggc     1560

agaauugcug agcugccuca gugugugggg ccgggaaacu gcguucucgu gcugcgcgaa     1620

guccugaccc uucucaucaa ugccgcguac aagcccucuc gggugcugag agagcugcag     1680

cucgacaaag acagcgugug gcauggcugu ggggagguuc ugaaggcuaa guauaaaggc     1740

aaguccuacc gcgccaccgu cgaaauugug aaaacagccg aucgggugac ggaguucugc     1800

agacaaaccu guaucaagcu ggaaugcugu ccuaaccugu uuggaccccg caugguccuc     1860

gacaaaugca gcgagaauug uucugugcug acaaagacca aguauacaca cuacuauggc     1920

aaaaagaaaa acaagcggau ugggagaccu cccggaggcc auuccaaucu ggcuugcgcc     1980

cuuaaaaagg cuagcaagcg gcgcaaaaga cggaagaacg uuuucgugca caaaaagaaa     2040

agaucuuccg ccagcgucga uaauaccccu gcggggucuc cccagggauc cggcggggaa     2100

gacgaggaug acccggauga gggcgacgau gacagccucu ccgaaggauc uacgagcgag     2160

cagcaggaug aacugcaaga ggaguccgaa augagcgaga agaaaucuug uuccagcucu     2220

ccuacacagu ccgaaaucag caccucucug cccccugacc gccagcggag aaagcgcgag     2280

cucagaaccu uuagcuucuc cgaugacgaa aacaagcccc cgagcccuaa agagauccgg     2340

auugaggugg ccgaacgccu gcaucuugac ucuaaucccc ugaagugguc cguugcugau     2400

guggucagau uuauccggag cacagacugc gccccucucg cucgcauuuu ccuggaucag     2460

gagaucgacg gccaagcccu gcuucuccug acccugccca cagugcagga augcauggau     2520

cucaaacugg ggcccgcgau uaaacuuugu caccacaucg agagaauuaa guuugccuuc     2580

uacgaacagu uugcuaacug a                                               2601


<210>  3352
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RU2__Homo_sapiens__Q9UHG0

<400>  3352

Met Ser Gly Ser Ser Ala Arg Ser Ser His Leu Ser Gln Pro Val Val 
1               5                   10                  15      


Lys Ser Val Leu Val Tyr Arg Asn Gly Asp Pro Phe Tyr Ala Gly Arg 
            20                  25                  30          


Arg Val Val Ile His Glu Lys Lys Val Ser Ser Phe Glu Val Phe Leu 
        35                  40                  45              


Lys Glu Val Thr Gly Gly Val Gln Ala Pro Phe Gly Ala Val Arg Asn 
    50                  55                  60                  


Ile Tyr Thr Pro Arg Thr Gly His Arg Ile Arg Lys Leu Asp Gln Ile 
65                  70                  75                  80  


Gln Ser Gly Gly Asn Tyr Val Ala Gly Gly Gln Glu Ala Phe Lys Lys 
                85                  90                  95      


Leu Asn Tyr Leu Asp Ile Gly Glu Ile Lys Lys Arg Pro Met Glu Val 
            100                 105                 110         


Val Asn Thr Glu Val Lys Pro Val Ile His Ser Arg Ile Asn Val Ser 
        115                 120                 125             


Ala Arg Phe Arg Lys Pro Leu Gln Glu Pro Cys Thr Ile Phe Leu Ile 
    130                 135                 140                 


Ala Asn Gly Asp Leu Ile Asn Pro Ala Ser Arg Leu Leu Ile Pro Arg 
145                 150                 155                 160 


Lys Thr Leu Asn Gln Trp Asp His Val Leu Gln Met Val Thr Glu Lys 
                165                 170                 175     


Ile Thr Leu Arg Ser Gly Ala Val His Arg Leu Tyr Thr Leu Glu Gly 
            180                 185                 190         


Lys Leu Val Glu Ser Gly Ala Glu Leu Glu Asn Gly Gln Phe Tyr Val 
        195                 200                 205             


Ala Val Gly Arg Asp Lys Phe Lys Lys Leu Pro Tyr Ser Glu Leu Leu 
    210                 215                 220                 


Phe Asp Lys Ser Thr Met Arg Arg Pro Phe Gly Gln Lys Ala Ser Ser 
225                 230                 235                 240 


Leu Pro Pro Ile Val Gly Ser Arg Lys Ser Lys Gly Ser Gly Asn Asp 
                245                 250                 255     


Arg His Ser Lys Ser Thr Val Gly Ser Ser Asp Asn Ser Ser Pro Gln 
            260                 265                 270         


Pro Leu Lys Arg Lys Gly Lys Lys Glu Asp Val Asn Ser Glu Lys Leu 
        275                 280                 285             


Thr Lys Leu Lys Gln Asn Val Lys Leu Lys Asn Ser Gln Glu Thr Ile 
    290                 295                 300                 


Pro Asn Ser Asp Glu Gly Ile Phe Lys Ala Gly Ala Glu Arg Ser Glu 
305                 310                 315                 320 


Thr Arg Gly Ala Ala Glu Val Gln Glu Asp Glu Asp Thr Gln Val Glu 
                325                 330                 335     


Val Pro Val Asp Gln Arg Pro Ala Glu Ile Val Asp Glu Glu Glu Asp 
            340                 345                 350         


Gly Glu Lys Ala Asn Lys Asp Ala Glu Gln Lys Glu Asp Phe Ser Gly 
        355                 360                 365             


Met Asn Gly Asp Leu Glu Glu Glu Gly Gly Arg Glu Ala Thr Asp Ala 
    370                 375                 380                 


Pro Glu Gln Val Glu Glu Ile Leu Asp His Ser Glu Gln Gln Ala Arg 
385                 390                 395                 400 


Pro Ala Arg Val Asn Gly Gly Thr Asp Glu Glu Asn Gly Glu Glu Leu 
                405                 410                 415     


Gln Gln Val Asn Asn Glu Leu Gln Leu Val Leu Asp Lys Glu Arg Lys 
            420                 425                 430         


Ser Gln Gly Ala Gly Ser Gly Gln Asp Glu Ala Asp Val Asp Pro Gln 
        435                 440                 445             


Arg Pro Pro Arg Pro Glu Val Lys Ile Thr Ser Pro Glu Glu Asn Glu 
    450                 455                 460                 


Asn Asn Gln Gln Asn Lys Asp Tyr Ala Ala Val Ala 
465                 470                 475     


<210>  3353
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RU2__Homo_sapiens__CCDS4550.1

<400>  3353
augagcggca gcagcgccag guccagccac cugucucagc ccgucgugaa gagcgugcuu       60

guguaccgca acggggaccc cuucuacgcg gggcgccgcg ucgucaucca ugagaagaag      120

guguccagcu ucgaagucuu ccugaaggag gugaccggcg gcguucaggc acccuuuggg      180

gccgucagga acaucuacac cccgcggacu ggccaccgaa uccggaagcu agaccagauc      240

cagagcgggg gcaauuacgu ggcuggaggc caggaagccu ucaagaaacu caauuacuug      300

gacauaggag aaaucaagaa aagaccaaug gaaguuguua auacagaggu aaaaccagua      360

auccauagca ggaucaacgu gucagcucgc uuuagaaaac cgcuucagga gccgugcacu      420

aucuucuuga uugcaaaugg agaccucaua aacccagcuu cucgccuccu uauccccaga      480

aaaaccuuga aucaguggga ucauguacua caaaugguca cagaaaaaau cacucugagg      540

agcggggcug uucacaggcu uuauacuuua gaaggaaaac uuguugagag uggagcagag      600

uuggagaaug ggcaguuuua uguggcuguu ggcagagaua aguuuaagaa acugccuuac      660

agugaguuac uuuuugacaa gucaacgaug agaaggccuu uuggucagaa agcuucuuca      720

cuaccuccua uuguaggauc cagaaagucu aaagggagug gaaaugaucg ccacucuaag      780

ucaacaguug gauccaguga caacucaucu ccucagcccc ugaagaggaa agggaaaaaa      840

gaagacguga auucagaaaa acugacgaaa uugaaacaaa auguaaaauu aaagaauuca      900

caagaaacca uuccaaauag ugaugaaggc auuuucaaag cuggagcaga gaggucugaa      960

acacgggggg cagcagaagu ccaagaagau gaagauacuc agguugaggu uccagucgau     1020

cagaggccag cagaaauagu agacgaggaa gaagauggag agaaggcaaa caaggaugca     1080

gaacagaaag aagacuuuuc aggaaugaau ggugaccuug aagaggaagg agguagggag     1140

gcuacagaug ccccugagca agucgaggag auucuggauc acagugagca gcaggcacgc     1200

ccugcucgug uaaauggagg caccgaugag gagaauggug aggagcugca gcagguuaau     1260

aaugagcuuc aacugguccu agacaaggaa agaaagucuc aaggagcugg caguggacaa     1320

gaugaggcug auguagaccc ucaaagacca ccaaggccag aaguaaaaau uaccagucca     1380

gaagaaaaug aaaacaacca acaaaacaag gacuaugcug ccguggcuua g              1431


<210>  3354
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RU2__Homo_sapiens__CCDS4550.1

<400>  3354
augagcggcu ccagcgcccg cuccagccac cugucccagc ccguggucaa gagcgugcuc       60

guguaccgga acggggaccc guucuacgcc ggccgccggg ucgugaucca cgagaagaag      120

guguccagcu ucgaggucuu ccugaaggag gugaccgggg gcgugcaggc gcccuucggg      180

gccguccgca acaucuacac gccccggacg ggccaccgca uccggaagcu ggaccagauc      240

caguccggcg ggaacuacgu ggccggcggg caggaggccu ucaagaagcu caacuaccug      300

gacaucggcg agaucaagaa gcgccccaug gaggugguca acaccgaggu gaagccggug      360

auccacagcc ggaucaacgu cuccgcccgc uuccggaagc cccugcagga gcccugcacc      420

aucuuccuca ucgcgaacgg ggaccugauc aaccccgcca gccgccugcu caucccgcgg      480

aagacccuga accaguggga ccacgugcug cagaugguga cggagaagau cacccuccgc      540

uccggcgccg uccaccggcu guacacccug gagggcaagc ucguggagag cggggccgag      600

cuggagaacg gccaguucua cguggcgguc gggcgcgaca aguucaagaa gcugcccuac      660

uccgagcucc uguucgacaa gagcaccaug cggcgccccu ucggccagaa ggccuccagc      720

cugcccccga ucgugggcuc ccgcaagagc aaggggagcg gcaacgaccg gcacuccaag      780

agcacggugg gguccagcga caacuccagc ccccagcccc ucaagcggaa gggcaagaag      840

gaggacguca acuccgagaa gcugaccaag cugaagcaga acgugaagcu caagaacagc      900

caggagacca uccccaacuc cgacgagggg aucuucaagg ccggcgccga gcgcagcgag      960

acccgcggcg ccgcggaggu ccaggaggac gaggacaccc agguggaggu gccggucgac     1020

cagcggcccg ccgagaucgu ggacgaggag gaggacgggg agaaggccaa caaggacgcc     1080

gagcagaagg aggacuucuc cggcaugaac ggggaccugg aggaggaggg cgggcgcgag     1140

gccaccgacg cgcccgagca ggucgaggag auccuggacc acagcgagca gcaggcccgg     1200

cccgcccgcg ugaacggcgg caccgacgag gagaacgggg aggagcucca gcaggucaac     1260

aacgagcugc agcuggugcu cgacaaggag cggaaguccc agggcgccgg gagcggccag     1320

gacgaggccg acguggaccc gcagcgcccg ccccggcccg aggugaagau caccuccccc     1380

gaggagaacg agaacaacca gcagaacaag gacuacgcgg ccguggccug a              1431


<210>  3355
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RU2__Homo_sapiens__CCDS4550.1

<400>  3355
auguccggcu ccuccgcccg cuccucccac cucucccagc ccgucgucaa guccguccuc       60

gucuaccgca acggcgaccc cuucuacgcc ggccgccgcg ucgucaucca cgagaagaag      120

gucuccuccu ucgaggucuu ccucaaggag gucaccggcg gcguccaggc ccccuucggc      180

gccguccgca acaucuacac cccccgcacc ggccaccgca uccgcaagcu cgaccagauc      240

caguccggcg gcaacuacgu cgccggcggc caggaggccu ucaagaagcu caacuaccuc      300

gacaucggcg agaucaagaa gcgccccaug gaggucguca acaccgaggu caagcccguc      360

auccacuccc gcaucaacgu cuccgcccgc uuccgcaagc cccuccagga gcccugcacc      420

aucuuccuca ucgccaacgg cgaccucauc aaccccgccu cccgccuccu caucccccgc      480

aagacccuca accaguggga ccacguccuc cagaugguca ccgagaagau cacccuccgc      540

uccggcgccg uccaccgccu cuacacccuc gagggcaagc ucgucgaguc cggcgccgag      600

cucgagaacg gccaguucua cgucgccguc ggccgcgaca aguucaagaa gcuccccuac      660

uccgagcucc ucuucgacaa guccaccaug cgccgccccu ucggccagaa ggccuccucc      720

cuccccccca ucgucggcuc ccgcaagucc aagggcuccg gcaacgaccg ccacuccaag      780

uccaccgucg gcuccuccga caacuccucc ccccagcccc ucaagcgcaa gggcaagaag      840

gaggacguca acuccgagaa gcucaccaag cucaagcaga acgucaagcu caagaacucc      900

caggagacca uccccaacuc cgacgagggc aucuucaagg ccggcgccga gcgcuccgag      960

acccgcggcg ccgccgaggu ccaggaggac gaggacaccc aggucgaggu ccccgucgac     1020

cagcgccccg ccgagaucgu cgacgaggag gaggacggcg agaaggccaa caaggacgcc     1080

gagcagaagg aggacuucuc cggcaugaac ggcgaccucg aggaggaggg cggccgcgag     1140

gccaccgacg cccccgagca ggucgaggag auccucgacc acuccgagca gcaggcccgc     1200

cccgcccgcg ucaacggcgg caccgacgag gagaacggcg aggagcucca gcaggucaac     1260

aacgagcucc agcucguccu cgacaaggag cgcaaguccc agggcgccgg cuccggccag     1320

gacgaggccg acgucgaccc ccagcgcccc ccccgccccg aggucaagau caccuccccc     1380

gaggagaacg agaacaacca gcagaacaag gacuacgccg ccgucgccug a              1431


<210>  3356
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RU2__Homo_sapiens__CCDS4550.1

<400>  3356
augagcggcu ccucugccag aucaagucac cugagccagc ccguggucaa guccguucuc       60

guguacagga acggggaccc uuucuaugcu ggacggcgcg uagugaucca ugagaaaaag      120

gucucuucgu uugaaguguu ccuuaaagag guuaccggug gcgugcaagc accauuuggg      180

gccguccgaa auauuuacac accgcguacu ggacacagaa uaaggaagcu ggaucagauc      240

cagucaggcg guaacuaugu ggcuggggga caggaagcgu ucaaaaaguu gaauuacuua      300

gacauuggcg agaucaagaa acggcccaug gaaguaguua acacggaggu gaagccuguc      360

auucauagcc gcaucaaugu gagugccaga uuuaggaaac cacugcaaga gcccugcacc      420

auauuccuaa ucgcaaacgg cgaucucauu aauccugccu cccggcugcu uaucccacgc      480

aagacacuga accaguggga ccacguguug cagaugguca cugaaaagau uacccuccga      540

ucuggggcug uucauagacu guauacacug gagggaaagc ucguggaaag cggugcagag      600

uuagagaaug gccaguuuua cguagccgug gggagggaua aguucaaaaa gcugcccuau      660

uccgaacuuu uguuugacaa aucaaccaug cggcguccuu ucggacaaaa ggcuaguagc      720

cugccaccga ucgucggcuc ucgcaaaucc aaggguucag ggaacgauag acacagcaaa      780

aguacugugg gaucuuccga caauagcucg ccccagccuc uaaagaggaa gggcaaaaag      840

gaggauguua acucugaaaa acucacaaag cugaaacaga augugaaacu uaagaacucc      900

caggagacca uaccaaauuc agacgaaggc auuuuuaaag ccggggcgga gcggagugag      960

acgcgaggag cagccgaagu ccaagaggau gaagacacuc agguggaggu acccguugau     1020

cagcgcccug cugaaaucgu ggacgaggag gaagacggug agaaggccaa caaagaugca     1080

gaacaaaagg aggacuucag cggcaugaac ggggaucugg aagaggaggg aggcagagaa     1140

gcuaccgacg ccccagagca ggucgaagag auuuuggauc acuccgagca gcaggcgagg     1200

cccgcccggg ugaauggugg gacagacgaa gagaacggcg aggaacucca acaggucaau     1260

aacgaacugc aguuagugcu ggauaaagag cgcaagucuc agggagcagg cagcgggcaa     1320

gacgaggcug auguugaccc gcagagaccu cccaggccag aagugaagau cacuucaccu     1380

gaggaaaaug agaacaauca gcagaacaaa gauuacgccg cuguagccug a              1431


<210>  3357
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RU2__Homo_sapiens__CCDS4550.1

<400>  3357
augagcggca gcagcgccag aagcagccac cugagccagc ccguggugaa gagcgugcug       60

guguacagaa acggcgaccc cuucuacgcc ggcagaagag uggugaucca cgagaagaag      120

gugagcagcu ucgagguguu ccugaaggag gugaccggcg gcgugcaggc ccccuucggc      180

gccgugagaa acaucuacac ccccagaacc ggccacagaa ucagaaagcu ggaccagauc      240

cagagcggcg gcaacuacgu ggccggcggc caggaggccu ucaagaagcu gaacuaccug      300

gacaucggcg agaucaagaa gagacccaug gaggugguga acaccgaggu gaagcccgug      360

auccacagca gaaucaacgu gagcgccaga uucagaaagc cccugcagga gcccugcacc      420

aucuuccuga ucgccaacgg cgaccugauc aaccccgcca gcagacugcu gauccccaga      480

aagacccuga accaguggga ccacgugcug cagaugguga ccgagaagau cacccugaga      540

agcggcgccg ugcacagacu guacacccug gagggcaagc ugguggagag cggcgccgag      600

cuggagaacg gccaguucua cguggccgug ggcagagaca aguucaagaa gcugcccuac      660

agcgagcugc uguucgacaa gagcaccaug agaagacccu ucggccagaa ggccagcagc      720

cugcccccca ucgugggcag cagaaagagc aagggcagcg gcaacgacag acacagcaag      780

agcaccgugg gcagcagcga caacagcagc ccccagcccc ugaagagaaa gggcaagaag      840

gaggacguga acagcgagaa gcugaccaag cugaagcaga acgugaagcu gaagaacagc      900

caggagacca uccccaacag cgacgagggc aucuucaagg ccggcgccga gagaagcgag      960

accagaggcg ccgccgaggu gcaggaggac gaggacaccc agguggaggu gcccguggac     1020

cagagacccg ccgagaucgu ggacgaggag gaggacggcg agaaggccaa caaggacgcc     1080

gagcagaagg aggacuucag cggcaugaac ggcgaccugg aggaggaggg cggcagagag     1140

gccaccgacg cccccgagca gguggaggag auccuggacc acagcgagca gcaggccaga     1200

cccgccagag ugaacggcgg caccgacgag gagaacggcg aggagcugca gcaggugaac     1260

aacgagcugc agcuggugcu ggacaaggag agaaagagcc agggcgccgg cagcggccag     1320

gacgaggccg acguggaccc ccagagaccc cccagacccg aggugaagau caccagcccc     1380

gaggagaacg agaacaacca gcagaacaag gacuacgccg ccguggccug a              1431


<210>  3358
<211>  1431
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RU2__Homo_sapiens__CCDS4550.1

<400>  3358
augagcggcu ccucugccag aagcucccac cugucucagc ccguggucaa gagcguucuc       60

guguaccgga acggggaccc uuucuaugcu ggacgcagag uggucaucca ugagaaaaag      120

guguccucuu uugaaguuuu ccugaaagag gugaccggcg ggguccaagc cccguuugga      180

gcggugcgga auauuuacac accccgcacg ggccacagaa uccggaaacu ugaucagauu      240

cagagcgggg gaaacuaugu ugcuggcggc caggaagccu ucaaaaagcu gaauuaccuc      300

gacaucgggg agauuaagaa acgcccuaug gaagugguca acaccgaggu gaagcccgug      360

auccauucca gaaucaaugu cagcgcccgg uuucgcaaac cucugcaaga gcccugcaca      420

auuuuccuua ucgcuaacgg agaucugauu aauccugccu cuagacuccu gaucccgcgg      480

aagacccuga accaguggga ccacguucuc cagaugguga cagaaaagau uacccugcgc      540

uccggcgcug ugcauagacu uuauacacug gaggggaagc ucgucgaaag cggagccgag      600

cuggagaaug gccaguuuua cguggcgguu gggcgggaua aguucaaaaa gcugcccuau      660

ucugaacuuc ucuuugacaa auccaccaug cgcagaccuu ucggacaaaa ggccagcucu      720

cugcccccua ucgugggcuc ccggaaaagc aagggcuccg ggaacgauag acacucuaaa      780

agcacggucg gauccagcga caauucuagc ccccagccgc ugaagcgcaa gggcaaaaag      840

gaggauguga acuccgaaaa acucaccaag cugaaacaga auguuaaacu uaagaacucu      900

caggagacaa uuccuaauag cgacgaaggg aucuuuaagg cuggagccga gcgguccgag      960

accagaggcg cugccgaagu gcaagaggau gaagacacac aggucgaggu gcccgucgau     1020

cagcgcccug cggaaaucgu ggacgaggag gaagacgggg agaaggccaa caaagaugcu     1080

gaacaaaagg aggacuucuc uggaaugaac ggcgaucugg aagaggaggg cgggcgggaa     1140

gccaccgacg cucccgagca gguugaagag auucucgauc acagcgagca gcaggccaga     1200

cccgcccgcg ugaauggagg cacggacgaa gagaacgggg aggaacugca acaggucaau     1260

aacgaacuuc agcuggugcu cgauaaagag cggaaguccc agggagcugg cagcgggcaa     1320

gacgaggcgg auguugaccc ucagagaccg ccccgcccug aagugaagau cacaucuccc     1380

gaggaaaaug agaacaauca gcagaacaaa gauuacgccg cugucgccug a              1431


<210>  3359
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RUNX1__Homo_sapiens__Q01196

<400>  3359

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  3360
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RUNX1__Homo_sapiens__BAA07903

<400>  3360
augcguaucc ccguagaugc cagcacgagc cgccgcuuca cgccgccuuc caccgcgcug       60

agcccaggca agaugagcga ggcguugccg cugggcgccc cggacgccgg cgcugcccug      120

gccggcaagc ugaggagcgg cgaccgcagc augguggagg ugcuggccga ccacccgggc      180

gagcuggugc gcaccgacag ccccaacuuc cucugcuccg ugcugccuac gcacuggcgc      240

ugcaacaaga cccugcccau cgcuuucaag gugguggccc uaggggaugu uccagauggc      300

acucugguca cugugauggc uggcaaugau gaaaacuacu cggcugagcu gagaaaugcu      360

accgcagcca ugaagaacca gguugcaaga uuuaaugacc ucagguuugu cggucgaagu      420

ggaagaggga aaagcuucac ucugaccauc acugucuuca caaacccacc gcaagucgcc      480

accuaccaca gagccaucaa aaucacagug gaugggcccc gagaaccucg aagacaucgg      540

cagaaacuag augaucagac caagcccggg agcuuguccu uuuccgagcg gcucagugaa      600

cuggagcagc ugcggcgcac agccaugagg gucagcccac accacccagc ccccacgccc      660

aacccucgug ccucccugaa ccacuccacu gccuuuaacc cucagccuca gagucagaug      720

caggauacaa ggcagaucca accaucccca ccgugguccu acgaucaguc cuaccaauac      780

cugggaucca uugccucucc uucugugcac ccagcaacgc ccauuucacc uggacgugcc      840

agcggcauga caacccucuc ugcagaacuu uccagucgac ucucaacggc acccgaccug      900

acagcguuca gcgacccgcg ccaguucccc gcgcugcccu ccaucuccga cccccgcaug      960

cacuauccag gcgccuucac cuacuccccg acgccgguca ccucgggcau cggcaucggc     1020

augucggcca ugggcucggc cacgcgcuac cacaccuacc ugccgccgcc cuaccccggc     1080

ucgucgcaag cgcagggagg cccguuccaa gccagcucgc ccuccuacca ccuguacuac     1140

ggcgccucgg ccggcuccua ccaguucucc auggugggcg gcgagcgcuc gccgccgcgc     1200

auccugccgc ccugcaccaa cgccuccacc ggcuccgcgc ugcucaaccc cagccucccg     1260

aaccagagcg acguggugga ggccgagggc agccacagca acucccccac caacauggcg     1320

cccuccgcgc gccuggagga ggccgugugg aggcccuacu ga                        1362


<210>  3361
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RUNX1__Homo_sapiens__BAA07903

<400>  3361
augcgcaucc ccguggacgc cagcaccucc cggcgcuuca ccccgcccag cacggcccug       60

ucccccggca agaugagcga ggcgcucccc cugggggccc cggacgccgg cgccgcccug      120

gcggggaagc uccgguccgg cgaccgcagc auggucgagg ugcuggccga ccaccccggg      180

gagcuggugc ggaccgacuc ccccaacuuc cucugcagcg uccugcccac ccacuggcgc      240

ugcaacaaga cccugccgau cgccuucaag gugguggccc ucggcgacgu ccccgacggc      300

acgcugguga ccgugauggc ggggaacgac gagaacuacu ccgccgagcu gcggaacgcc      360

accgccgcca ugaagaacca ggucgcgcgc uucaacgacc uccgguucgu gggccgcagc      420

gggcggggca aguccuucac ccugacgauc accguguuca ccaacccgcc ccaggucgcc      480

accuaccacc gcgccaucaa gaucacggug gacgggcccc gggagccccg ccggcaccgc      540

cagaagcugg acgaccagac caagcccggc agccucuccu ucagcgagcg gcuguccgag      600

cuggagcagc uccgccggac cgccaugcgc gugagccccc accacccggc ccccaccccc      660

aacccccggg cgucccugaa ccacagcacg gccuucaacc cgcagcccca gucccagaug      720

caggacaccc gccagaucca gcccagcccg cccuggagcu acgaccaguc cuaccaguac      780

cugggcagca ucgccucccc cagcguccac cccgccaccc ccaucucccc ggggcgcgcc      840

agcggcauga ccacgcucuc cgcggagcug agcucccggc ugagcaccgc ccccgaccuc      900

accgccuucu ccgacccccg ccaguucccg gcccugccca gcaucuccga cccccggaug      960

cacuaccccg gggccuucac cuacagcccg acgcccguga ccuccggcau cggcaucggg     1020

augagcgcga ugggcuccgc cacccgcuac cacaccuacc ugcccccgcc cuaccccggg     1080

agcucccagg cccagggcgg gcccuuccag gccagcagcc ccuccuacca ccucuacuac     1140

ggcgcgagcg ccggcuccua ccaguucagc auggucgggg gcgagcgguc cccgccccgc     1200

auccugccgc ccugcacgaa cgccagcacc ggguccgccc ugcucaaccc cagccugccc     1260

aaccaguccg acguggugga ggccgagggc agccacucca acagccccac caacauggcg     1320

cccuccgccc ggcuggagga ggccgugugg cgcccguacu ga                        1362


<210>  3362
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RUNX1__Homo_sapiens__BAA07903

<400>  3362
augcgcaucc ccgucgacgc cuccaccucc cgccgcuuca ccccccccuc caccgcccuc       60

ucccccggca agauguccga ggcccucccc cucggcgccc ccgacgccgg cgccgcccuc      120

gccggcaagc uccgcuccgg cgaccgcucc auggucgagg uccucgccga ccaccccggc      180

gagcucgucc gcaccgacuc ccccaacuuc cucugcuccg uccuccccac ccacuggcgc      240

ugcaacaaga cccuccccau cgccuucaag gucgucgccc ucggcgacgu ccccgacggc      300

acccucguca ccgucauggc cggcaacgac gagaacuacu ccgccgagcu ccgcaacgcc      360

accgccgcca ugaagaacca ggucgcccgc uucaacgacc uccgcuucgu cggccgcucc      420

ggccgcggca aguccuucac ccucaccauc accgucuuca ccaacccccc ccaggucgcc      480

accuaccacc gcgccaucaa gaucaccguc gacggccccc gcgagccccg ccgccaccgc      540

cagaagcucg acgaccagac caagcccggc ucccucuccu ucuccgagcg ccucuccgag      600

cucgagcagc uccgccgcac cgccaugcgc gucucccccc accaccccgc ccccaccccc      660

aacccccgcg ccucccucaa ccacuccacc gccuucaacc cccagcccca gucccagaug      720

caggacaccc gccagaucca gcccuccccc cccugguccu acgaccaguc cuaccaguac      780

cucggcucca ucgccucccc cuccguccac cccgccaccc ccaucucccc cggccgcgcc      840

uccggcauga ccacccucuc cgccgagcuc uccucccgcc ucuccaccgc ccccgaccuc      900

accgccuucu ccgacccccg ccaguucccc gcccuccccu ccaucuccga cccccgcaug      960

cacuaccccg gcgccuucac cuacuccccc acccccguca ccuccggcau cggcaucggc     1020

auguccgcca ugggcuccgc cacccgcuac cacaccuacc uccccccccc cuaccccggc     1080

uccucccagg cccagggcgg ccccuuccag gccuccuccc ccuccuacca ccucuacuac     1140

ggcgccuccg ccggcuccua ccaguucucc auggucggcg gcgagcgcuc ccccccccgc     1200

auccuccccc ccugcaccaa cgccuccacc ggcuccgccc uccucaaccc cucccucccc     1260

aaccaguccg acgucgucga ggccgagggc ucccacucca acucccccac caacauggcc     1320

cccuccgccc gccucgagga ggccgucugg cgccccuacu ga                        1362


<210>  3363
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RUNX1__Homo_sapiens__BAA07903

<400>  3363
augagaaucc ccguggacgc cagcaccucc aggcgguuca caccuccauc uacugcucug       60

ucaccgggca agaugaguga ggcacucccc cuuggggccc cugaugcggg agcugcccug      120

gcagguaaau ugcgcagcgg cgaccgaucc auggucgaag uuuuagccga ucacccaggg      180

gagcuggugc guacggacuc ucccaacuuu cuaugcucgg uacucccuac ccauuggaga      240

uguaauaaga cacugccaau ugcuuucaaa guggucgcac uuggagaugu gcccgacggc      300

acucugguua ccgugauggc cgguaacgau gaaaauuacu cagcugaguu gaggaacgcc      360

acagcggcaa ugaagaauca ggucgcccgg uuuaacgacc uccgcuucgu ggggagaagc      420

ggaaggggca aaaguuuuac ccugacuaua acaguauuca ccaauccucc acaaguugcu      480

acguaucacc gggccaucaa gauuacugug gauggcccgc gcgaaccccg aagacauagg      540

cagaagcugg acgaucagac caaaccuggg ucccucucuu uuagcgagcg guuauccgag      600

cuggaacagc uucgucgcac agcaaugaga gucucaccac accaucccgc uccuacucca      660

aaccccaggg ccaguuugaa ucacagcacc gcguucaacc cgcaaccuca gucucagaug      720

caggacacac ggcaaaucca gcccucccca ccuuggucau acgaucagag cuaucaguac      780

cugggaagua uugccucucc cuccgugcac ccagcaaccc ccaucagccc uggucgagcu      840

ucgggcauga cgacucuauc ugccgagcuc uccucacgcc ugaguacagc uccagaccuu      900

accgccuuua gcgacccgag acaauucccc gcacugccuu ccauaucuga uccaaggaug      960

cauuaucccg gggccuuuac uuacagcccu acaccaguga ccucaggaau cggcauuggu     1020

augagugcua ugggguccgc gacgcgguau cacaccuacu ugcccccgcc uuacccagga     1080

agcucucagg cacagggcgg ccccuuccaa gccucaaguc cuagcuauca ucucuacuau     1140

ggggcuuccg ccggaucuua ccaguuuucg auggucggug gcgaacgcag cccacccaga     1200

auccugccuc ccugcacaaa ugcauccacu gggucagccu uacugaaccc aagucucccg     1260

aaucagucug acguugugga ggcugaggga agccacucca acucaccuac caauauggcc     1320

cccagcgcaa ggcuugaaga ggcgguaugg cguccauauu ga                        1362


<210>  3364
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RUNX1__Homo_sapiens__BAA07903

<400>  3364
augagaaucc ccguggacgc cagcaccagc agaagauuca ccccccccag caccgcccug       60

agccccggca agaugagcga ggcccugccc cugggcgccc ccgacgccgg cgccgcccug      120

gccggcaagc ugagaagcgg cgacagaagc augguggagg ugcuggccga ccaccccggc      180

gagcugguga gaaccgacag ccccaacuuc cugugcagcg ugcugcccac ccacuggaga      240

ugcaacaaga cccugcccau cgccuucaag gugguggccc ugggcgacgu gcccgacggc      300

acccugguga ccgugauggc cggcaacgac gagaacuaca gcgccgagcu gagaaacgcc      360

accgccgcca ugaagaacca gguggccaga uucaacgacc ugagauucgu gggcagaagc      420

ggcagaggca agagcuucac ccugaccauc accguguuca ccaacccccc ccagguggcc      480

accuaccaca gagccaucaa gaucaccgug gacggcccca gagagcccag aagacacaga      540

cagaagcugg acgaccagac caagcccggc agccugagcu ucagcgagag acugagcgag      600

cuggagcagc ugagaagaac cgccaugaga gugagccccc accaccccgc ccccaccccc      660

aaccccagag ccagccugaa ccacagcacc gccuucaacc cccagcccca gagccagaug      720

caggacacca gacagaucca gcccagcccc cccuggagcu acgaccagag cuaccaguac      780

cugggcagca ucgccagccc cagcgugcac cccgccaccc ccaucagccc cggcagagcc      840

agcggcauga ccacccugag cgccgagcug agcagcagac ugagcaccgc ccccgaccug      900

accgccuuca gcgaccccag acaguucccc gcccugccca gcaucagcga ccccagaaug      960

cacuaccccg gcgccuucac cuacagcccc acccccguga ccagcggcau cggcaucggc     1020

augagcgcca ugggcagcgc caccagauac cacaccuacc ugcccccccc cuaccccggc     1080

agcagccagg cccagggcgg ccccuuccag gccagcagcc ccagcuacca ccuguacuac     1140

ggcgccagcg ccggcagcua ccaguucagc auggugggcg gcgagagaag cccccccaga     1200

auccugcccc ccugcaccaa cgccagcacc ggcagcgccc ugcugaaccc cagccugccc     1260

aaccagagcg acguggugga ggccgagggc agccacagca acagccccac caacauggcc     1320

cccagcgcca gacuggagga ggccgugugg agacccuacu ga                        1362


<210>  3365
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RUNX1__Homo_sapiens__BAA07903

<400>  3365
augagaaucc ccguggacgc cagcaccucc cggcgcuuca caccuccguc uacggcucug       60

agccccggca agauguccga ggcccucccu cugggggcgc ccgaugcugg agccgcccuu      120

gcuggcaaac ugagaucugg ggaccggagc auggucgaag uucucgccga ucacccugga      180

gagcuggugc gcaccgacuc ccccaacuuu cuuugcucug ugcugccuac acauuggaga      240

uguaauaaga cccucccgau ugcuuucaaa gucguggccc ugggcgaugu ucccgacggg      300

acacugguga ccgucauggc gggaaacgau gaaaauuaca gcgccgagcu ccggaacgcu      360

acagccgcua ugaagaauca gguggcccgc uuuaacgacc ugagauucgu uggccggucc      420

ggccgcggga aaucuuuuac ccuuacgauc accguguuca caaauccucc ccaagucgcg      480

accuaucaca gagccauuaa gaucacagug gauggaccuc gggaaccccg cagacaucgg      540

cagaagcugg acgaucagac caaaccgggc agccucuccu uuagcgagcg ccugucugag      600

cuugaacagc ugagacggac ggcuaugaga guguccccuc accaucccgc cccuacaccc      660

aacccccgcg cuagccucaa ucacucuacc gccuucaacc cucaaccgca gucccagaug      720

caggacacac ggcaaauuca gcccagcccu cccugguccu acgaucaguc uuaucaguac      780

cuggggagca ucgccucccc uagcguccac cccgcuaccc cgaucucucc ugggagagcg      840

uccggcauga ccacacugag cgccgagcuc ucuagccgcc uguccacggc ucccgaccuu      900

accgccuuuu cugacccucg gcaauucccc gcccugccua gcauuuccga ucccagaaug      960

cauuauccgg gggcuuuuac auacagcccu acccccguua caucuggaau cggcauuggc     1020

auguccgcca uggggagcgc gacccgcuau cacacguacc ugcccccucc guaccccgga     1080

ucuucccagg cucagggcgg gccuuuccaa gccagcuccc ccucuuauca ucucuacuau     1140

ggagccagcg cuggcuccua ccaguuuucu auggugggag gagaacggag cccucccaga     1200

auccuuccuc ccugcacaaa ugccuccacc ggcagcgcuc ugcucaaccc gucucugccu     1260

aaucaguccg acguggucga ggccgagggc agccacucua acucccccac caauauggcg     1320

ccuagcgccc gccuggaaga ggcugugugg cggcccuauu ga                        1362


<210>  3366
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  S-100__Homo_sapiens__V9HW39

<400>  3366

Met Pro Leu Glu Leu Glu Leu Cys Pro Gly Arg Trp Val Gly Gly Gln 
1               5                   10                  15      


His Pro Cys Phe Ile Ile Ala Glu Ile Gly Gln Asn His Gln Gly Asp 
            20                  25                  30          


Leu Asp Val Ala Lys Arg Met Ile Arg Met Ala Lys Glu Cys Gly Ala 
        35                  40                  45              


Asp Cys Ala Lys Phe Gln Lys Ser Glu Leu Glu Phe Lys Phe Asn Arg 
    50                  55                  60                  


Lys Ala Leu Glu Arg Pro Tyr Thr Ser Lys His Ser Trp Gly Lys Thr 
65                  70                  75                  80  


Tyr Gly Glu His Lys Arg His Leu Glu Phe Ser His Asp Gln Tyr Arg 
                85                  90                  95      


Glu Leu Gln Arg Tyr Ala Glu Glu Val Gly Ile Phe Phe Thr Ala Ser 
            100                 105                 110         


Gly Met Asp Glu Met Ala Val Glu Phe Leu His Glu Leu Asn Val Pro 
        115                 120                 125             


Phe Phe Lys Val Gly Ser Gly Asp Thr Asn Asn Phe Pro Tyr Leu Glu 
    130                 135                 140                 


Lys Thr Ala Lys Lys Gly Arg Pro Met Val Ile Ser Ser Gly Met Gln 
145                 150                 155                 160 


Ser Met Asp Thr Met Lys Gln Val Tyr Gln Ile Val Lys Pro Leu Asn 
                165                 170                 175     


Pro Asn Phe Cys Phe Leu Gln Cys Thr Ser Ala Tyr Pro Leu Gln Pro 
            180                 185                 190         


Glu Asp Val Asn Leu Arg Val Ile Ser Glu Tyr Gln Lys Leu Phe Pro 
        195                 200                 205             


Asp Ile Pro Ile Gly Tyr Ser Gly His Glu Thr Gly Ile Ala Ile Ser 
    210                 215                 220                 


Val Ala Ala Val Ala Leu Gly Ala Lys Val Leu Glu Arg His Ile Thr 
225                 230                 235                 240 


Leu Asp Lys Thr Trp Lys Gly Ser Asp His Ser Ala Ser Leu Glu Pro 
                245                 250                 255     


Gly Glu Leu Ala Glu Leu Val Arg Ser Val Arg Leu Val Glu Arg Ala 
            260                 265                 270         


Leu Gly Ser Pro Thr Lys Gln Leu Leu Pro Cys Glu Met Ala Cys Asn 
        275                 280                 285             


Glu Lys Leu Gly Lys Ser Val Val Ala Lys Val Lys Ile Pro Glu Gly 
    290                 295                 300                 


Thr Ile Leu Thr Met Asp Met Leu Thr Val Lys Val Gly Glu Pro Lys 
305                 310                 315                 320 


Ala Tyr Pro Pro Glu Asp Ile Phe Asn Leu Val Gly Lys Lys Val Leu 
                325                 330                 335     


Val Thr Val Glu Glu Asp Asp Thr Ile Met Glu Glu Leu Val Asp Asn 
            340                 345                 350         


His Gly Lys Lys Ile Lys Ser 
        355                 


<210>  3367
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  S-100__Homo_sapiens__ACI46041

<400>  3367
augccgcugg agcuggagcu gugucccggg cgcugggugg gcgggcaaca cccgugcuuc       60

aucauugccg agaucggcca gaaccaccag ggcgaccugg acguagccaa gcgcaugauc      120

cgcauggcca aggagugugg ggcugauugu gccaaguucc agaagaguga gcuagaauuc      180

aaguuuaauc ggaaagccuu ggagaggcca uacaccucga agcauuccug ggggaagacg      240

uacggggagc acaaacgaca ucuggaguuc agccaugacc aguacaggga gcugcagagg      300

uacgccgagg agguugggau cuucuucacu gccucuggca uggaugagau ggcaguugaa      360

uuccugcaug aacugaaugu uccauuuuuc aaaguuggau cuggagacac uaauaauuuu      420

ccuuaucugg aaaagacagc caaaaaaggu cgcccaaugg ugaucuccag ugggaugcag      480

ucaauggaca ccaugaagca aguuuaucag aucgugaagc cccucaaccc caacuucugc      540

uucuugcagu guaccagcgc auacccgcuc cagccugagg acgucaaccu gcgggucauc      600

ucggaauauc agaagcucuu uccugacauu cccauagggu auucugggca ugaaacaggc      660

auagcgauau cuguggccgc aguggcucug ggggccaagg uguuggaacg ucacauaacu      720

uuggacaaga ccuggaaggg gagugaccac ucggccucgc uggagccugg agaacuggcc      780

gagcuggugc ggucagugcg ucuuguggag cgugcccugg gcuccccaac caagcagcug      840

cugcccugug agauggccug caaugagaag cugggcaagu cugugguggc caaagugaaa      900

auuccggaag gcaccauucu aacaauggac augcucaccg ugaagguggg ugagcccaaa      960

gccuauccuc cugaagacau cuuuaaucua gugggcaaga agguccuggu cacuguugaa     1020

gaggaugaca ccaucaugga agaauuggua gauaaucaug gcaaaaaaau caagucuuaa     1080


<210>  3368
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       S-100__Homo_sapiens__ACI46041

<400>  3368
augccccugg agcucgagcu gugccccggc cgcugggucg ggggccagca ccccugcuuc       60

aucaucgccg agaucgggca gaaccaccag ggcgaccugg acguggccaa gcggaugauc      120

cgcauggcga aggagugcgg ggccgacugc gccaaguucc agaaguccga gcucgaguuc      180

aaguucaacc ggaaggcccu ggagcgcccc uacaccagca agcacagcug gggcaagacc      240

uacggcgagc acaagcggca ccuggaguuc ucccacgacc aguaccgcga gcuccagcgg      300

uacgccgagg agguggggau cuucuucacg gcgagcggca uggacgagau ggccguggag      360

uuccugcacg agcugaacgu ccccuucuuc aagguggggu ccggcgacac caacaacuuc      420

ccguaccucg agaagaccgc caagaagggg cgccccaugg ugaucagcuc cggcaugcag      480

agcauggaca ccaugaagca ggucuaccag aucgugaagc cccugaaccc caacuucugc      540

uuccugcagu gcacguccgc cuacccgcuc cagcccgagg acgugaaccu gcgggucauc      600

agcgaguacc agaagcuguu ccccgacauc cccaucggcu acuccgggca cgagaccggc      660

aucgcgauca gcguggccgc cguggcccuc ggggccaagg uccuggagcg ccacaucacc      720

cuggacaaga ccuggaaggg cuccgaccac agcgcguccc ucgagccggg cgagcuggcc      780

gagcuggugc ggagcgugcg ccucgucgag cgggcccugg ggucccccac gaagcagcug      840

cuccccugcg agauggccug caacgagaag cugggcaaga gcgugguggc caaggucaag      900

auccccgagg ggaccauccu gaccauggac augcucaccg ugaagguggg cgagccgaag      960

gcguacccgc ccgaggacau cuucaaccug gucgggaaga aggugcuggu gacggucgag     1020

gaggacgaca ccaucaugga ggagcucgug gacaaccacg gcaagaagau caaguccuga     1080


<210>  3369
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       S-100__Homo_sapiens__ACI46041

<400>  3369
augccccucg agcucgagcu cugccccggc cgcugggucg gcggccagca ccccugcuuc       60

aucaucgccg agaucggcca gaaccaccag ggcgaccucg acgucgccaa gcgcaugauc      120

cgcauggcca aggagugcgg cgccgacugc gccaaguucc agaaguccga gcucgaguuc      180

aaguucaacc gcaaggcccu cgagcgcccc uacaccucca agcacuccug gggcaagacc      240

uacggcgagc acaagcgcca ccucgaguuc ucccacgacc aguaccgcga gcuccagcgc      300

uacgccgagg aggucggcau cuucuucacc gccuccggca uggacgagau ggccgucgag      360

uuccuccacg agcucaacgu ccccuucuuc aaggucggcu ccggcgacac caacaacuuc      420

cccuaccucg agaagaccgc caagaagggc cgccccaugg ucaucuccuc cggcaugcag      480

uccauggaca ccaugaagca ggucuaccag aucgucaagc cccucaaccc caacuucugc      540

uuccuccagu gcaccuccgc cuacccccuc cagcccgagg acgucaaccu ccgcgucauc      600

uccgaguacc agaagcucuu ccccgacauc cccaucggcu acuccggcca cgagaccggc      660

aucgccaucu ccgucgccgc cgucgcccuc ggcgccaagg uccucgagcg ccacaucacc      720

cucgacaaga ccuggaaggg cuccgaccac uccgccuccc ucgagcccgg cgagcucgcc      780

gagcucgucc gcuccguccg ccucgucgag cgcgcccucg gcucccccac caagcagcuc      840

cuccccugcg agauggccug caacgagaag cucggcaagu ccgucgucgc caaggucaag      900

auccccgagg gcaccauccu caccauggac augcucaccg ucaaggucgg cgagcccaag      960

gccuaccccc ccgaggacau cuucaaccuc gucggcaaga agguccucgu caccgucgag     1020

gaggacgaca ccaucaugga ggagcucguc gacaaccacg gcaagaagau caaguccuga     1080


<210>  3370
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       S-100__Homo_sapiens__ACI46041

<400>  3370
augccccugg agcucgaacu uugcccuggc agaugggucg ggggacagca cccauguuuc       60

aucauugccg agauagguca aaaccaucag ggcgaccugg auguggcuaa gaggaugauc      120

cggauggcaa aagaaugcgg ggccgacugu gcgaaguuuc agaaaagcga guuggaauuu      180

aaguuuaauc gcaaggcuuu agagcgaccg uacaccucca agcacucuug gggaaagaca      240

uauggcgagc auaaacguca ccuggaguuc ucacaugauc aguacagaga gcuacaaagg      300

uaugccgaag agguugguau uuucuucacu gcaaguggga uggacgagau ggccguggaa      360

uuucuccacg agcugaacgu acccuucuuu aaggugggaa gcggcgauac gaauaacuuc      420

ccuuaccuug agaaaaccgc uaagaaaggc cggccaaugg ucaucuccuc ugggaugcag      480

ucgauggaca caaugaaaca gguguaucag auuguuaagc cccugaaucc uaacuuuugc      540

uucuugcaau guacuucagc auacccacuc cagcccgaag augugaaucu gcgcgucauc      600

agcgaauauc agaaacuguu uccugacaua ccaaucggau acagugguca cgagaccggc      660

auugccaucu ccguggcugc cguagcgcuc ggggcaaagg uuuuagagag acauauuaca      720

cuggauaaaa ccuggaaggg aucugaccac agcgccuccc uugaaccggg cgaguuggcu      780

gaacugguga ggucaguccg gcuaguggag cgcgcccucg guagucccac uaaacagcug      840

cuuccuugcg aaauggcaug uaacgagaag cuggggaaaa gcguggucgc uaagguuaag      900

aucccagagg gaacaauauu gaccauggau augcucacgg ugaaaguagg cgaacccaag      960

gccuacccuc cagaggacau uuucaaucug gugggcaaaa aggucuuagu gacuguugaa     1020

gaggaugaca ccaucaugga agaacuggug gacaaccaug ggaaaaagau uaagucuuga     1080


<210>  3371
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       S-100__Homo_sapiens__ACI46041

<400>  3371
augccccugg agcuggagcu gugccccggc agaugggugg gcggccagca ccccugcuuc       60

aucaucgccg agaucggcca gaaccaccag ggcgaccugg acguggccaa gagaaugauc      120

agaauggcca aggagugcgg cgccgacugc gccaaguucc agaagagcga gcuggaguuc      180

aaguucaaca gaaaggcccu ggagagaccc uacaccagca agcacagcug gggcaagacc      240

uacggcgagc acaagagaca ccuggaguuc agccacgacc aguacagaga gcugcagaga      300

uacgccgagg aggugggcau cuucuucacc gccagcggca uggacgagau ggccguggag      360

uuccugcacg agcugaacgu gcccuucuuc aaggugggca gcggcgacac caacaacuuc      420

cccuaccugg agaagaccgc caagaagggc agacccaugg ugaucagcag cggcaugcag      480

agcauggaca ccaugaagca gguguaccag aucgugaagc cccugaaccc caacuucugc      540

uuccugcagu gcaccagcgc cuacccccug cagcccgagg acgugaaccu gagagugauc      600

agcgaguacc agaagcuguu ccccgacauc cccaucggcu acagcggcca cgagaccggc      660

aucgccauca gcguggccgc cguggcccug ggcgccaagg ugcuggagag acacaucacc      720

cuggacaaga ccuggaaggg cagcgaccac agcgccagcc uggagcccgg cgagcuggcc      780

gagcugguga gaagcgugag acugguggag agagcccugg gcagccccac caagcagcug      840

cugcccugcg agauggccug caacgagaag cugggcaaga gcgugguggc caaggugaag      900

auccccgagg gcaccauccu gaccauggac augcugaccg ugaagguggg cgagcccaag      960

gccuaccccc ccgaggacau cuucaaccug gugggcaaga aggugcuggu gaccguggag     1020

gaggacgaca ccaucaugga ggagcuggug gacaaccacg gcaagaagau caagagcuga     1080


<210>  3372
<211>  1080
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       S-100__Homo_sapiens__ACI46041

<400>  3372
augccccugg agcucgaacu gugcccuggc agaugggugg gaggacagca cccguguuuc       60

aucauugccg agaucggcca aaaccaucag ggggaccuug augucgcuaa gcggaugauu      120

cgcauggcca aagaaugcgg agcggacugu gcuaaguuuc agaaaagcga gcuggaguuc      180

aaguuuaaua gaaaagcccu cgagcggccc uacaccucca agcacucuug gggcaagaca      240

uauggggagc auaaacgcca ccuggaguuc agccaugauc aguacagaga acuucaacgg      300

uaugccgaag agguuggaau cuuuuucacg gcuuccggca uggacgagau ggccguggaa      360

uuucugcacg agcucaacgu gccuuucuuu aaggucggcu cuggggauac caauaacuuc      420

cccuaccugg agaaaacagc uaagaaagga cgcccuaugg ugauuagcuc cggcaugcag      480

ucuauggaca ccaugaagca gguuuaucag aucgugaagc cccugaaucc uaacuuuugc      540

uuccuccaau guacaagcgc cuacccgcug cagcccgaag augucaaucu uagagugauc      600

uccgaauauc agaaacuguu uccugacauu cccaucgggu acagcggaca cgagaccggc      660

auugcgaucu cuguugccgc uguggcccuc ggggcuaagg uccuggagcg gcauauuaca      720

cuugauaaaa ccuggaaggg auccgaccac agcgccucuc uggaaccugg cgagcucgcg      780

gaacuggugc gcuccgugag acuggucgag cgggcccucg gcagccccac gaaacagcug      840

cuuccgugcg aaauggcuug uaacgagaag cuggggaaau cuguuguggc caaggugaag      900

aucccugagg gaaccauucu cacaauggau augcugaccg ucaaaguggg cgaacccaag      960

gcuuacccuc ccgaggacau cuucaaucuu guugggaaaa aggugcuggu cacaguggaa     1020

gaggaugaca ccaucaugga agaacucguu gacaaccaug ggaaaaagau uaaguccuga     1080


<210>  3373
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SAGE__Homo_sapiens__Q9NXZ1

<400>  3373

Met Gln Ala Ser Pro Leu Gln Thr Ser Gln Pro Thr Pro Pro Glu Glu 
1               5                   10                  15      


Leu His Ala Ala Ala Tyr Val Phe Thr Asn Asp Gly Gln Gln Met Arg 
            20                  25                  30          


Ser Asp Glu Val Asn Leu Val Ala Thr Gly His Gln Ser Lys Lys Lys 
        35                  40                  45              


His Ser Arg Lys Ser Lys Arg His Ser Ser Ser Lys Arg Arg Lys Ser 
    50                  55                  60                  


Met Ser Ser Trp Leu Asp Lys Gln Glu Asp Ala Ala Val Thr His Ser 
65                  70                  75                  80  


Ile Cys Glu Glu Arg Ile Asn Asn Gly Gln Pro Val Ala Asp Asn Val 
                85                  90                  95      


Leu Ser Thr Ala Pro Pro Trp Pro Asp Ala Thr Ile Ala His Asn Ile 
            100                 105                 110         


Arg Glu Glu Arg Met Glu Asn Gly Gln Ser Arg Thr Asp Lys Val Leu 
        115                 120                 125             


Ser Thr Ala Pro Pro Gln Leu Val His Met Ala Ala Ala Gly Ile Pro 
    130                 135                 140                 


Ser Met Ser Thr Arg Asp Leu His Ser Thr Val Thr His Asn Ile Arg 
145                 150                 155                 160 


Glu Glu Arg Met Glu Asn Gly Gln Pro Gln Pro Asp Asn Val Leu Ser 
                165                 170                 175     


Thr Gly Pro Thr Gly Leu Ile Asn Met Ala Ala Thr Pro Ile Pro Ala 
            180                 185                 190         


Met Ser Ala Arg Asp Leu Tyr Ala Thr Val Thr His Asn Val Cys Glu 
        195                 200                 205             


Gln Lys Met Glu Asn Val Gln Pro Ala Pro Asp Asn Val Leu Leu Thr 
    210                 215                 220                 


Leu Arg Pro Arg Arg Ile Asn Met Thr Asp Thr Gly Ile Ser Pro Met 
225                 230                 235                 240 


Ser Thr Arg Asp Pro Tyr Ala Thr Ile Thr Tyr Asn Val Pro Glu Glu 
                245                 250                 255     


Lys Met Glu Lys Gly Gln Pro Gln Pro Asp Asn Ile Leu Ser Thr Ala 
            260                 265                 270         


Ser Thr Gly Leu Ile Asn Val Ala Gly Ala Gly Thr Pro Ala Ile Ser 
        275                 280                 285             


Thr Asn Gly Leu Tyr Ser Thr Val Pro His Asn Val Cys Glu Glu Lys 
    290                 295                 300                 


Met Glu Asn Asp Gln Pro Gln Pro Asn Asn Val Leu Ser Thr Val Gln 
305                 310                 315                 320 


Pro Val Ile Ile Tyr Leu Thr Ala Thr Gly Ile Pro Gly Met Asn Thr 
                325                 330                 335     


Arg Asp Gln Tyr Ala Thr Ile Thr His Asn Val Cys Glu Glu Arg Val 
            340                 345                 350         


Val Asn Asn Gln Pro Leu Pro Ser Asn Ala Leu Ser Thr Val Leu Pro 
        355                 360                 365             


Gly Leu Ala Tyr Leu Ala Thr Ala Asp Met Pro Ala Met Ser Thr Arg 
    370                 375                 380                 


Asp Gln His Ala Thr Ile Ile His Asn Leu Arg Glu Glu Lys Lys Asp 
385                 390                 395                 400 


Asn Ser Gln Pro Thr Pro Asp Asn Val Leu Ser Ala Val Thr Pro Glu 
                405                 410                 415     


Leu Ile Asn Leu Ala Gly Ala Gly Ile Pro Pro Met Ser Thr Arg Asp 
            420                 425                 430         


Gln Tyr Ala Thr Val Asn His His Val His Glu Ala Arg Met Glu Asn 
        435                 440                 445             


Gly Gln Arg Lys Gln Asp Asn Val Leu Ser Asn Val Leu Ser Gly Leu 
    450                 455                 460                 


Ile Asn Met Ala Gly Ala Ser Ile Pro Ala Met Ser Ser Arg Asp Leu 
465                 470                 475                 480 


Tyr Ala Thr Ile Thr His Ser Val Arg Glu Glu Lys Met Glu Ser Gly 
                485                 490                 495     


Lys Pro Gln Thr Asp Lys Val Ile Ser Asn Asp Ala Pro Gln Leu Gly 
            500                 505                 510         


His Met Ala Ala Gly Gly Ile Pro Ser Met Ser Thr Lys Asp Leu Tyr 
        515                 520                 525             


Ala Thr Val Thr Gln Asn Val His Glu Glu Arg Met Glu Asn Asn Gln 
    530                 535                 540                 


Pro Gln Pro Ser Tyr Asp Leu Ser Thr Val Leu Pro Gly Leu Thr Tyr 
545                 550                 555                 560 


Leu Thr Val Ala Gly Ile Pro Ala Met Ser Thr Arg Asp Gln Tyr Ala 
                565                 570                 575     


Thr Val Thr His Asn Val His Glu Glu Lys Ile Lys Asn Gly Gln Ala 
            580                 585                 590         


Ala Ser Asp Asn Val Phe Ser Thr Val Pro Pro Ala Phe Ile Asn Met 
        595                 600                 605             


Ala Ala Thr Gly Val Ser Ser Met Ser Thr Arg Asp Gln Tyr Ala Ala 
    610                 615                 620                 


Val Thr His Asn Ile Arg Glu Glu Lys Ile Asn Asn Ser Gln Pro Ala 
625                 630                 635                 640 


Pro Gly Asn Ile Leu Ser Thr Ala Pro Pro Trp Leu Arg His Met Ala 
                645                 650                 655     


Ala Ala Gly Ile Ser Ser Thr Ile Thr Arg Asp Leu Tyr Val Thr Ala 
            660                 665                 670         


Thr His Ser Val His Glu Glu Lys Met Thr Asn Gly Gln Gln Ala Pro 
        675                 680                 685             


Asp Asn Ser Leu Ser Thr Val Pro Pro Gly Cys Ile Asn Leu Ser Gly 
    690                 695                 700                 


Ala Gly Ile Ser Cys Arg Ser Thr Arg Asp Leu Tyr Ala Thr Val Ile 
705                 710                 715                 720 


His Asp Ile Gln Glu Glu Glu Met Glu Asn Asp Gln Thr Pro Pro Asp 
                725                 730                 735     


Gly Phe Leu Ser Asn Ser Asp Ser Pro Glu Leu Ile Asn Met Thr Gly 
            740                 745                 750         


His Cys Met Pro Pro Asn Ala Leu Asp Ser Phe Ser His Asp Phe Thr 
        755                 760                 765             


Ser Leu Ser Lys Asp Glu Leu Leu Tyr Lys Pro Asp Ser Asn Glu Phe 
    770                 775                 780                 


Ala Val Gly Thr Lys Asn Tyr Ser Val Ser Ala Gly Asp Pro Pro Val 
785                 790                 795                 800 


Thr Val Met Ser Leu Val Glu Thr Val Pro Asn Thr Pro Gln Ile Ser 
                805                 810                 815     


Pro Ala Met Ala Lys Lys Ile Asn Asp Asp Ile Lys Tyr Gln Leu Met 
            820                 825                 830         


Lys Glu Val Arg Arg Phe Gly Gln Asn Tyr Glu Arg Ile Phe Ile Leu 
        835                 840                 845             


Leu Glu Glu Val Gln Gly Ser Met Lys Val Lys Arg Gln Phe Val Glu 
    850                 855                 860                 


Phe Thr Ile Lys Glu Ala Ala Arg Phe Lys Lys Val Val Leu Ile Gln 
865                 870                 875                 880 


Gln Leu Glu Lys Ala Leu Lys Glu Ile Asp Ser His Cys His Leu Arg 
                885                 890                 895     


Lys Val Lys His Met Arg Lys Arg 
            900                 


<210>  3374
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SAGE__Homo_sapiens__CCDS14652.1

<400>  3374
augcaggcuu cuccacuuca aacgagucaa ccaacuccac cugaagaacu ucaugcugcu       60

gccuaugugu uuacaaauga ugggcagcaa augaggagug augaaguaaa ucugguugca      120

acagggcauc aaagcaaaaa gaaacauucc agaaaaucca agagacacuc uucaucuaag      180

agaaggaaga guauguccuc gugguuagac aaacaggaag augcugcagu cacucacagc      240

auuugugaag agaggauaaa uaacggccaa ccaguagcug auaaugucuu gucaacugcu      300

ccaccauggc cugaugcuac caucgcucac aauauccgug aagagaggau ggaaaauggc      360

caaucucgaa cugacaaagu cuugucaacu gcuccaccac agcuuguuca uauggcugca      420

gcugguauuc cauccaugag uaccagggau cugcauucua ccgucacuca caauauccgu      480

gaagagagaa uggaaaaugg ccaaccccaa ccugauaacg ucuugucaac uggucccaca      540

gggcuuauua auauggcagc aacuccuauu ccagccauga gugccagaga ucucuaugcu      600

acagucacuc acaaugucug ugaacagaag auggaaaaug uccaaccagc accugauaac      660

guguuguuga cucuucgacc acggcguauu aauaugacag acacugguau uucacccaug      720

aguaccaggg auccauaugc uaccaucacu uacaaugucc cugaggagaa gauggaaaag      780

ggccaacccc aaccugauaa caucuuguca acugcuucaa cagggcuuau uaauguggca      840

ggagcuggua cuccagccau cagcaccaau ggccuguauu ccaccguccc ucacaauguc      900

ugugaagaga agauggaaaa ugaccaaccg caaccuaaua acguauuguc aacuguucaa      960

ccagugauua uuuauuugac agcaacuggu auuccgggca ugaauaccag ggaucaguau     1020

gcuaccauca cucacaaugu cugugaagag agagugguaa auaaccaacc acuaccuagu     1080

aacgccuugu caacuguucu accagggcuu gcuuauuugg caacagcuga uaugccagcc     1140

augaguacca gggaucagca ugcuaccauc auucacaauc ugcgugaaga gaagaaagau     1200

aacagccaac caaccccuga uaacgucuug ucagcuguua caccagagcu uauuaacuug     1260

gcaggagcug guauuccacc caugaguacc agggaucagu augcuaccgu caaucaccau     1320

guccaugaag caaggaugga aaauggccaa cgaaaacagg auaacgucuu gucaaauguu     1380

cuauccgggc uuauuaauau ggcaggagcu aguauuccag caaugaguuc cagggaucug     1440

uaugcuacca uuacucacag uguucgugaa gagaagaugg aaaguggcaa accccaaacu     1500

gauaagguca uaucaaauga ugcaccacag cuuggucaua uggcugcagg ugguauucca     1560

uccaugagua ccaaggaucu guaugcuacc gucacucaaa auguccauga agagaggaug     1620

gaaaauaacc aaccacaacc uaguuaugac uugucaacug uucuaccagg acuuacuuau     1680

uugacaguag cugguauucc ggccaugagu accagggauc aguaugcuac cgucacucac     1740

aauguccaug aagagaagau uaaaaauggc caagcagcau ccgauaaugu cuucucgacu     1800

guuccaccag cauuuauuaa uauggcagca acugguguuu cauccaugag uaccagggau     1860

caguaugcug cagucacuca caacauccgu gaagagaaga uaaauaacag ccaaccagca     1920

ccugguaaca ucuugucaac ugcuccucca uggcuucguc auauggcagc agcuggaauu     1980

ucauccacga uuaccaggga ucuguauguc accgccacuc acagugucca ugaggagaag     2040

augacaaaug gccaacaggc accugauaac uccuugucaa cgguuccacc ugguuguauu     2100

aaucugucag gagcugguau uucaugcaga aguaccaggg aucuguaugc uacugucauu     2160

cacgauaucc aggaggagga gauggaaaau gaucaaaccc cuccugaugg cuuccuguca     2220

aauucugauu caccagagcu gauaaauaug acaggacauu guaugccacc caaugcauug     2280

gauucuuucu cucacgacuu cacaagucuc agcaaagaug agcugcuuua caaaccugau     2340

aguaaugaau uugcgguagg caccaaaaac uacagugucu cugcagguga cccaccaguu     2400

acaguaaugu cuuuggugga aacugugcca aauacaccac aaauaucucc ugccauggca     2460

aagaaaauua augaugauau aaaauaucaa uuaaugaaag aaguucgaag guuugggcaa     2520

aauuaugaaa gaauuuucau uuugcuugaa gagguacaag gaucuaugaa agucaagaga     2580

caauuuguug aauuuaccau caaggaagca gcaagguuua aaaaaguugu cuuaauucag     2640

caacucgaga aggcgcuuaa agaaauagau ucccacugcc aucucagaaa aguuaagcac     2700

augagaaaaa gauaa                                                      2715


<210>  3375
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SAGE__Homo_sapiens__CCDS14652.1

<400>  3375
augcaggcca gcccccugca gaccucccag cccaccccgc ccgaggagcu gcacgccgcg       60

gccuacgugu ucaccaacga cggccagcag augcgcagcg acgaggucaa ccugguggcc      120

accgggcacc aguccaagaa gaagcacagc cggaagucca agcgccacag cuccagcaag      180

cggcgcaagu ccaugagcuc cuggcuggac aagcaggagg acgccgccgu gacccacagc      240

aucugcgagg agcggaucaa caacggccag cccgucgcgg acaacgugcu cuccaccgcc      300

ccgcccuggc ccgacgccac gaucgcccac aacauccgcg aggagcggau ggagaacggg      360

cagagccgca ccgacaaggu gcuguccacc gcgcccccgc agcuggucca cauggccgcc      420

gccggcaucc ccagcauguc cacccgggac cuccacagca cggugaccca caacauccgc      480

gaggagcgga uggagaacgg gcagccccag cccgacaacg ugcuguccac cggcccgacc      540

ggccugauca acauggccgc gacgcccauc cccgccauga gcgcccgcga ccucuacgcc      600

accgucaccc acaacgugug cgagcagaag auggagaacg ugcagcccgc cccggacaac      660

guccugcuga cccuccggcc ccgccggauc aacaugacgg acaccgggau cagccccaug      720

uccacccgcg accccuacgc gaccaucacg uacaacgugc cggaggagaa gauggagaag      780

ggccagcccc agcccgacaa cauccugagc accgccucca ccgggcugau caacguggcc      840

ggcgccggga cccccgccau cagcacgaac ggccucuacu ccaccguccc gcacaacgug      900

ugcgaggaga agauggagaa cgaccagccc cagcccaaca acgugcugag caccguccag      960

cccgugauca ucuaccugac cgcgacgggc auccccggga ugaacacccg ggaccaguac     1020

gccaccauca cccacaacgu gugcgaggag cgcgucguga acaaccagcc ccuccccucc     1080

aacgcccuga gcacggugcu gccgggccuc gccuaccugg ccaccgcgga caugcccgcc     1140

auguccaccc gggaccagca cgccaccauc auccacaacc ugcgcgagga gaagaaggac     1200

aacagccagc ccacgcccga caacguccuc uccgccguga ccccggagcu gaucaaccug     1260

gcgggggccg gcaucccgcc caugagcacc cgggaccagu acgccaccgu caaccaccac     1320

gugcacgagg cccgcaugga gaacggccag cgcaagcagg acaacgugcu cuccaacguc     1380

cugagcgggc ugaucaacau ggccggcgcg uccauccccg ccaugagcuc ccgggaccuc     1440

uacgccacca ucacgcacag cgugcgcgag gagaagaugg aguccgggaa gccccagacc     1500

gacaagguga ucagcaacga cgcgccccag cugggccaca uggccgccgg gggcaucccc     1560

agcaugucca ccaaggaccu guacgccacc gucacgcaga acgugcacga ggagcggaug     1620

gagaacaacc agccccagcc gagcuacgac cucuccaccg ugcugcccgg ccugaccuac     1680

cucaccgucg ccgggauccc cgccaugagc acgcgcgacc aguacgccac cgugacccac     1740

aacgugcacg aggagaagau caagaacggc caggcggccu ccgacaacgu cuucagcacc     1800

gugcccccgg ccuucaucaa cauggccgcg acgggggugu ccagcauguc cacccgggac     1860

caguacgccg ccgucaccca caacauccgc gaggagaaga ucaacaacag ccagcccgcc     1920

cccggcaaca uccuguccac cgcgccgccc uggcugcggc acauggccgc cgccgggauc     1980

agcuccacga ucacccgcga ccucuacgug accgccaccc acagcgugca cgaggagaag     2040

augacgaacg gccagcaggc ccccgacaac ucccugagca ccgucccgcc cggcugcauc     2100

aaccuguccg gggcgggcau cagcugccgg agcacccgcg accucuacgc caccgugauc     2160

cacgacaucc aggaggagga gauggagaac gaccagacgc cgcccgacgg guuccugucc     2220

aacagcgacu cccccgagcu gaucaacaug accggccacu gcaugccgcc caacgcccuc     2280

gacagcuucu cccacgacuu caccagccug uccaaggacg agcugcucua caagcccgac     2340

agcaacgagu ucgccguggg gaccaagaac uacuccguca gcgccggcga cccgcccgug     2400

acggugaugu cccuggucga gaccgugccc aacacgcccc agaucagccc cgcgauggcc     2460

aagaagauca acgacgacau caaguaccag cugaugaagg aggugcggcg cuucggccag     2520

aacuacgagc ggaucuucau ccugcucgag gagguccagg gguccaugaa ggugaagcgc     2580

caguucgugg aguucaccau caaggaggcc gcccgguuca agaaggucgu gcugauccag     2640

cagcuggaga aggcgcucaa ggagaucgac agccacugcc accuccgcaa ggugaagcac     2700

augcggaagc gcuga                                                      2715


<210>  3376
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SAGE__Homo_sapiens__CCDS14652.1

<400>  3376
augcaggccu ccccccucca gaccucccag cccacccccc ccgaggagcu ccacgccgcc       60

gccuacgucu ucaccaacga cggccagcag augcgcuccg acgaggucaa ccucgucgcc      120

accggccacc aguccaagaa gaagcacucc cgcaagucca agcgccacuc cuccuccaag      180

cgccgcaagu ccauguccuc cuggcucgac aagcaggagg acgccgccgu cacccacucc      240

aucugcgagg agcgcaucaa caacggccag cccgucgccg acaacguccu cuccaccgcc      300

ccccccuggc ccgacgccac caucgcccac aacauccgcg aggagcgcau ggagaacggc      360

cagucccgca ccgacaaggu ccucuccacc gccccccccc agcucgucca cauggccgcc      420

gccggcaucc ccuccauguc cacccgcgac cuccacucca ccgucaccca caacauccgc      480

gaggagcgca uggagaacgg ccagccccag cccgacaacg uccucuccac cggccccacc      540

ggccucauca acauggccgc cacccccauc cccgccaugu ccgcccgcga ccucuacgcc      600

accgucaccc acaacgucug cgagcagaag auggagaacg uccagcccgc ccccgacaac      660

guccuccuca cccuccgccc ccgccgcauc aacaugaccg acaccggcau cucccccaug      720

uccacccgcg accccuacgc caccaucacc uacaacgucc ccgaggagaa gauggagaag      780

ggccagcccc agcccgacaa cauccucucc accgccucca ccggccucau caacgucgcc      840

ggcgccggca cccccgccau cuccaccaac ggccucuacu ccaccguccc ccacaacguc      900

ugcgaggaga agauggagaa cgaccagccc cagcccaaca acguccucuc caccguccag      960

cccgucauca ucuaccucac cgccaccggc auccccggca ugaacacccg cgaccaguac     1020

gccaccauca cccacaacgu cugcgaggag cgcgucguca acaaccagcc ccuccccucc     1080

aacgcccucu ccaccguccu ccccggccuc gccuaccucg ccaccgccga caugcccgcc     1140

auguccaccc gcgaccagca cgccaccauc auccacaacc uccgcgagga gaagaaggac     1200

aacucccagc ccacccccga caacguccuc uccgccguca cccccgagcu caucaaccuc     1260

gccggcgccg gcaucccccc cauguccacc cgcgaccagu acgccaccgu caaccaccac     1320

guccacgagg cccgcaugga gaacggccag cgcaagcagg acaacguccu cuccaacguc     1380

cucuccggcc ucaucaacau ggccggcgcc uccauccccg ccauguccuc ccgcgaccuc     1440

uacgccacca ucacccacuc cguccgcgag gagaagaugg aguccggcaa gccccagacc     1500

gacaagguca ucuccaacga cgccccccag cucggccaca uggccgccgg cggcaucccc     1560

uccaugucca ccaaggaccu cuacgccacc gucacccaga acguccacga ggagcgcaug     1620

gagaacaacc agccccagcc cuccuacgac cucuccaccg uccuccccgg ccucaccuac     1680

cucaccgucg ccggcauccc cgccaugucc acccgcgacc aguacgccac cgucacccac     1740

aacguccacg aggagaagau caagaacggc caggccgccu ccgacaacgu cuucuccacc     1800

gucccccccg ccuucaucaa cauggccgcc accggcgucu ccuccauguc cacccgcgac     1860

caguacgccg ccgucaccca caacauccgc gaggagaaga ucaacaacuc ccagcccgcc     1920

cccggcaaca uccucuccac cgcccccccc uggcuccgcc acauggccgc cgccggcauc     1980

uccuccacca ucacccgcga ccucuacguc accgccaccc acuccgucca cgaggagaag     2040

augaccaacg gccagcaggc ccccgacaac ucccucucca ccgucccccc cggcugcauc     2100

aaccucuccg gcgccggcau cuccugccgc uccacccgcg accucuacgc caccgucauc     2160

cacgacaucc aggaggagga gauggagaac gaccagaccc cccccgacgg cuuccucucc     2220

aacuccgacu cccccgagcu caucaacaug accggccacu gcaugccccc caacgcccuc     2280

gacuccuucu cccacgacuu caccucccuc uccaaggacg agcuccucua caagcccgac     2340

uccaacgagu ucgccgucgg caccaagaac uacuccgucu ccgccggcga cccccccguc     2400

accgucaugu cccucgucga gaccgucccc aacacccccc agaucucccc cgccauggcc     2460

aagaagauca acgacgacau caaguaccag cucaugaagg agguccgccg cuucggccag     2520

aacuacgagc gcaucuucau ccuccucgag gagguccagg gcuccaugaa ggucaagcgc     2580

caguucgucg aguucaccau caaggaggcc gcccgcuuca agaaggucgu ccucauccag     2640

cagcucgaga aggcccucaa ggagaucgac ucccacugcc accuccgcaa ggucaagcac     2700

augcgcaagc gcuga                                                      2715


<210>  3377
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SAGE__Homo_sapiens__CCDS14652.1

<400>  3377
augcaggcca gcccccugca aaccucccag ccuacaccac cggaggaacu ccacgcugca       60

gccuacgugu ucacuaacga cggccagcag augagaucug augaggucaa ucuuguugcg      120

acggggcauc aaucaaagaa aaagcacagu aggaaaagca agcggcauuc cucuucgaaa      180

cgccgaaagu caaugagcag uuggcuggac aagcaggaag augcugccgu gacccacucc      240

aucugcgagg aacguauuaa caauggacag cccguagcag acaacguguu gucuacagcc      300

ccuccauggc ccgaugcuac uauagcacau aauaucagag aggagaggau ggaaaacggu      360

cagagccgga ccgacaaagu cuuauccaca gccccuccac aacuggugca cauggcugcc      420

gcgggcauuc ccucaaugag uacccgcgau cuacacagca cuguuacaca uaauaucaga      480

gaggaaagga uggagaacgg gcagccucag ccagacaaug ugcucucuac cggaccgacg      540

ggccugauua acauggcagc cacucccauc ccugcuaugu ccgcccggga ucuuuaugca      600

accgucacac acaaugugug ugagcagaag auggaaaacg uacaaccagc ucccgacaau      660

guucuguuga cucuccgccc ucgaagaaua aacaugaccg auacagguau cucaccaaug      720

agcaccaggg accccuacgc cacgauuacu uauaaugugc cggaggagaa aauggagaag      780

gggcagccuc agcccgauaa cauccugagu acagcgucua ccggacugau uaacgucgcc      840

ggcgcaggca cuccagcuau cuccacaaau gggcucuaca gcaccgugcc ucauaacgug      900

ugcgaagaga aaauggagaa ugaccaaccc cagccaaaca augucuuauc gacgguucag      960

cccgugauaa uuuaucugac cgccacagga aucccuggua ugaacacucg ggaccaguac     1020

gcuaccauua cacacaaugu augugaagaa cgugugguca acaaucaacc acuuccgucu     1080

aacgccuugu ccacugugcu gcccggccua gcauaucucg ccaccgcuga uaugccugcg     1140

augucaacac gcgaccagca cgcaaccauc auccauaauc ugagagaaga gaagaaggau     1200

aacagucagc caacucccga caauguucuu agcgccguga cgccugaacu gauuaacuug     1260

gcuggggccg gaauaccacc cauguccaca agggaucagu acgcaaccgu caaucaccau     1320

gugcacgagg cccggaugga gaacggccaa cgaaaacagg acaacguacu cucuaauguu     1380

cugagcgguu uaaucaacau ggcuggggcc ucaauuccgg caaugaguuc ccgcgaucug     1440

uacgcgacua ucacccauag cgugagagaa gagaagaugg aaucuggaaa accucagaca     1500

gacaagguca uaucaaauga ugcuccacag cucggccaca uggccgcagg cgggauuccc     1560

aguaugagca ccaaagaccu uuaugccacu gugacacaaa acguccacga ggaaaggaug     1620

gagaauaacc agccucagcc cuccuacgau cugucuacgg uguugccagg acuaaccuau     1680

cugacuguug cugguauccc ugccaugucg acacgggacc aguacgcaac cgugacacau     1740

aauguacacg aggaaaagau caaaaacggc caagcugcca gcgacaaugu cuuuuccacu     1800

gugcccccag cguucauuaa cauggccgcu accgggguuu caaguauguc uacgcgcgau     1860

caguaugcag ccgugaccca uaauaucaga gaggaaaaga uuaacaauag ccagccggcu     1920

ccuggaaaca uacucuccac agcaccccca uggcugaggc acauggccgc ggccggcauc     1980

ucaagcacua uuacccguga ccuuuacguc acagcuacuc acucugugca ugaggagaag     2040

augaccaaug gucaacaggc ccccgauaac ucccugagua cgguaccucc agggugcauc     2100

aacuugagcg gcgcaggaau cucuugucgg uccacacgag accucuaugc uaccgugauu     2160

cacgauauac aggaagagga aauggagaau gaccagacuc ccccugaugg cuuucuguca     2220

aacagugaca gcccggaauu aaucaauaug acagggcauu gcaugccacc caacgcccug     2280

gauucguucu cccacgacuu uaccucucua agcaaagaug agcuccugua caagccugac     2340

ucaaaugagu ucgcaguugg aacuaaaaac uacagugucu ccgccgguga uccacccgug     2400

accgugaugu cucuugucga aacaguuccu aauacgccgc aaauuagccc cgcuauggcg     2460

aagaaaauca acgacgacau uaaguaucag uugaugaagg aggugagaag guuuggccag     2520

aauuacgaac gcaucuucau acugcucgag gaagugcagg gguccaugaa aguaaagcgg     2580

caauuugucg aguucaccau caaagaggcc gcaagauuua agaaaguggu ucugauucag     2640

cagcuugaaa aggcucugaa ggagaucgau ucacauuguc acuugaggaa agugaagcac     2700

augcgcaaac gauga                                                      2715


<210>  3378
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SAGE__Homo_sapiens__CCDS14652.1

<400>  3378
augcaggcca gcccccugca gaccagccag cccacccccc ccgaggagcu gcacgccgcc       60

gccuacgugu ucaccaacga cggccagcag augagaagcg acgaggugaa ccugguggcc      120

accggccacc agagcaagaa gaagcacagc agaaagagca agagacacag cagcagcaag      180

agaagaaaga gcaugagcag cuggcuggac aagcaggagg acgccgccgu gacccacagc      240

aucugcgagg agagaaucaa caacggccag cccguggccg acaacgugcu gagcaccgcc      300

ccccccuggc ccgacgccac caucgcccac aacaucagag aggagagaau ggagaacggc      360

cagagcagaa ccgacaaggu gcugagcacc gccccccccc agcuggugca cauggccgcc      420

gccggcaucc ccagcaugag caccagagac cugcacagca ccgugaccca caacaucaga      480

gaggagagaa uggagaacgg ccagccccag cccgacaacg ugcugagcac cggccccacc      540

ggccugauca acauggccgc cacccccauc cccgccauga gcgccagaga ccuguacgcc      600

accgugaccc acaacgugug cgagcagaag auggagaacg ugcagcccgc ccccgacaac      660

gugcugcuga cccugagacc cagaagaauc aacaugaccg acaccggcau cagccccaug      720

agcaccagag accccuacgc caccaucacc uacaacgugc ccgaggagaa gauggagaag      780

ggccagcccc agcccgacaa cauccugagc accgccagca ccggccugau caacguggcc      840

ggcgccggca cccccgccau cagcaccaac ggccuguaca gcaccgugcc ccacaacgug      900

ugcgaggaga agauggagaa cgaccagccc cagcccaaca acgugcugag caccgugcag      960

cccgugauca ucuaccugac cgccaccggc auccccggca ugaacaccag agaccaguac     1020

gccaccauca cccacaacgu gugcgaggag agagugguga acaaccagcc ccugcccagc     1080

aacgcccuga gcaccgugcu gcccggccug gccuaccugg ccaccgccga caugcccgcc     1140

augagcacca gagaccagca cgccaccauc auccacaacc ugagagagga gaagaaggac     1200

aacagccagc ccacccccga caacgugcug agcgccguga cccccgagcu gaucaaccug     1260

gccggcgccg gcaucccccc caugagcacc agagaccagu acgccaccgu gaaccaccac     1320

gugcacgagg ccagaaugga gaacggccag agaaagcagg acaacgugcu gagcaacgug     1380

cugagcggcc ugaucaacau ggccggcgcc agcauccccg ccaugagcag cagagaccug     1440

uacgccacca ucacccacag cgugagagag gagaagaugg agagcggcaa gccccagacc     1500

gacaagguga ucagcaacga cgccccccag cugggccaca uggccgccgg cggcaucccc     1560

agcaugagca ccaaggaccu guacgccacc gugacccaga acgugcacga ggagagaaug     1620

gagaacaacc agccccagcc cagcuacgac cugagcaccg ugcugcccgg ccugaccuac     1680

cugaccgugg ccggcauccc cgccaugagc accagagacc aguacgccac cgugacccac     1740

aacgugcacg aggagaagau caagaacggc caggccgcca gcgacaacgu guucagcacc     1800

gugccccccg ccuucaucaa cauggccgcc accggcguga gcagcaugag caccagagac     1860

caguacgccg ccgugaccca caacaucaga gaggagaaga ucaacaacag ccagcccgcc     1920

cccggcaaca uccugagcac cgcccccccc uggcugagac acauggccgc cgccggcauc     1980

agcagcacca ucaccagaga ccuguacgug accgccaccc acagcgugca cgaggagaag     2040

augaccaacg gccagcaggc ccccgacaac agccugagca ccgugccccc cggcugcauc     2100

aaccugagcg gcgccggcau cagcugcaga agcaccagag accuguacgc caccgugauc     2160

cacgacaucc aggaggagga gauggagaac gaccagaccc cccccgacgg cuuccugagc     2220

aacagcgaca gccccgagcu gaucaacaug accggccacu gcaugccccc caacgcccug     2280

gacagcuuca gccacgacuu caccagccug agcaaggacg agcugcugua caagcccgac     2340

agcaacgagu ucgccguggg caccaagaac uacagcguga gcgccggcga cccccccgug     2400

accgugauga gccuggugga gaccgugccc aacacccccc agaucagccc cgccauggcc     2460

aagaagauca acgacgacau caaguaccag cugaugaagg aggugagaag auucggccag     2520

aacuacgaga gaaucuucau ccugcuggag gaggugcagg gcagcaugaa ggugaagaga     2580

caguucgugg aguucaccau caaggaggcc gccagauuca agaagguggu gcugauccag     2640

cagcuggaga aggcccugaa ggagaucgac agccacugcc accugagaaa ggugaagcac     2700

augagaaaga gauga                                                      2715


<210>  3379
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SAGE__Homo_sapiens__CCDS14652.1

<400>  3379
augcaggcca gcccccugca aaccucccag ccuacaccgc ccgaggaacu ccacgcugcc       60

gcguacgugu ucacgaacga cggccagcag augagaucug augaggucaa ucugguugcu      120

accgggcacc aaagcaagaa aaagcacucc cggaaaucua agcgccauag cuccucuaaa      180

agacggaaaa gcauguccag cuggcuugac aagcaggaag augccgccgu gacacacucu      240

aucugcgagg aacgcauuaa caauggacag ccuguggcug acaacguccu guccaccgcu      300

cccccuuggc ccgaugccac aaucgcccau aauauuagag aggagcggau ggaaaacggc      360

cagagccgca ccgacaaagu gcucucuaca gcgccuccgc aacugguuca cauggccgcu      420

gccgggaucc ccuccaugag caccagagau cuucacucua cggugaccca uaauauucgg      480

gaggaacgca uggagaacgg acagccucag cccgacaaug uccuguccac aggcccuacc      540

gggcucauca acauggcugc cacacccauc ccggcgauga gcgccagaga ucuguaugcu      600

accgugacgc acaauguuug ugagcagaag auggaaaacg ugcaaccugc ccccgacaau      660

guccugcuca cacugcggcc ucgcagaauu aacaugaccg auacaggaau cucccccaug      720

ucuacccggg accccuacgc uaccauuaca uauaaugugc cugaggaaaa gauggagaag      780

ggccagccgc agcccgauaa cauccuuagc acggccucca ccggccugau uaacguggcc      840

ggggcuggaa ccccugcgau cagcaccaau ggccucuacu cuacaguccc ccauaacguu      900

ugcgaagaga aaauggagaa ugaccaaccu cagcccaaca augugcuguc caccgugcag      960

ccggucauua ucuaucuuac ggccacaggg aucccuggaa ugaacacccg cgaccaguac     1020

gcuaccauua cacacaaugu gugugaagag agaguuguga acaaucaacc ccugccuagc     1080

aacgcccucu cuaccguccu gcccggccug gccuaucucg cuacagccga uaugccugcg     1140

augagcacgc gggaccagca cgcuaccauc auucauaauc ugagagaaga gaagaaggau     1200

aacucccagc ccacaccgga caaugugcuu ucugccguua ccccugaacu gaucaaccuc     1260

gccggggcug gcauuccucc caugagcaca cgcgaucagu acgccaccgu gaaucaccau     1320

guccacgagg cucggaugga gaacggacaa agaaaacagg acaacgugcu guccaauguc     1380

cuuagcggcc ugaucaacau ggccggggcg ucuauccccg ccauguccag ccgcgaucuc     1440

uacgcuacga uuacccauuc ugugcgggaa gagaagaugg aauccggaaa accgcagaca     1500

gacaagguua ucagcaauga ugcuccccag cugggccaca uggccgccgg gggcauuccu     1560

uccaugucua ccaaagaccu guaugcgaca gugacccaaa acguccacga ggaaagaaug     1620

gagaauaacc agccccagcc uagcuacgau cucuccacgg ugcugcccgg acuuacauau     1680

cugaccguug ccgggauccc ugcuaugucu acacgcgacc aguacgccac cgugacccau     1740

aauguccacg aggaaaagau uaaaaacgga caagcugcca gcgacaaugu guuuuccaca     1800

gugcccccgg ccuucaucaa cauggcugcg acgggcguua gcucuauguc cacccgggau     1860

caguaugccg cugucacaca uaauaucaga gaggaaaaga uuaacaauag ccagccugcc     1920

cccggcaaca uccucucuac cgccccuccc uggcugcgcc acauggcugc cgcggggauu     1980

uccagcacaa ucacccggga ccuuuacgug acggcuacac acucugugca ugaggagaag     2040

augaccaaug gacaacaggc cccggauaac agccugucca ccgucccucc cggcugcauu     2100

aaccucagcg gggccggaau cucuuguaga uccacacgcg accuguaugc uaccgugauu     2160

cacgauaucc aggaagagga aauggagaau gaccagacac cucccgaugg cuuucugagc     2220

aacuccgacu cucccgaacu caucaauaug acggggcauu gcaugccucc gaacgcccug     2280

gauagcuucu cccacgacuu uaccucucuu agcaaagaug agcugcucua caagcccgac     2340

uccaaugagu ucgcgguugg caccaaaaac uacucuguga gcgcuggaga uccucccguc     2400

acagugaugu cccugguuga aacagugccu aauacacccc aaauuagccc ugccauggcc     2460

aagaaaauca acgacgacau uaaguaucag cugaugaagg agguccggag auuuggccag     2520

aauuacgaac ggaucuucau ucuucucgag gaagugcagg ggucuaugaa aguuaagcgc     2580

caauuugugg aguucacgau caaagaggcu gccagauuua agaaagucgu gcugauccag     2640

cagcuggaaa aggcucucaa ggagauugau ucccauuguc aucugcggaa agugaagcac     2700

augagaaaac gcuga                                                      2715


<210>  3380
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SART-_1__Homo_sapiens__O43290

<400>  3380

Met Gly Ser Ser Lys Lys His Arg Gly Glu Lys Glu Ala Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Ala Gly Thr Gly Gly Ala Thr Glu Gln Pro Pro Arg His 
            20                  25                  30          


Arg Glu His Lys Lys His Lys His Arg Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Glu Arg Arg Lys Arg Ser Arg Glu Arg Gly Gly Glu Arg Gly 
    50                  55                  60                  


Ser Gly Arg Arg Gly Ala Glu Ala Glu Ala Arg Ser Ser Thr His Gly 
65                  70                  75                  80  


Arg Glu Arg Ser Gln Ala Glu Pro Ser Glu Arg Arg Val Lys Arg Glu 
                85                  90                  95      


Lys Arg Asp Asp Gly Tyr Glu Ala Ala Ala Ser Ser Lys Thr Ser Ser 
            100                 105                 110         


Gly Asp Ala Ser Ser Leu Ser Ile Glu Glu Thr Asn Lys Leu Arg Ala 
        115                 120                 125             


Lys Leu Gly Leu Lys Pro Leu Glu Val Asn Ala Ile Lys Lys Glu Ala 
    130                 135                 140                 


Gly Thr Lys Glu Glu Pro Val Thr Ala Asp Val Ile Asn Pro Met Ala 
145                 150                 155                 160 


Leu Arg Gln Arg Glu Glu Leu Arg Glu Lys Leu Ala Ala Ala Lys Glu 
                165                 170                 175     


Lys Arg Leu Leu Asn Gln Lys Leu Gly Lys Ile Lys Thr Leu Gly Glu 
            180                 185                 190         


Asp Asp Pro Trp Leu Asp Asp Thr Ala Ala Trp Ile Glu Arg Ser Arg 
        195                 200                 205             


Gln Leu Gln Lys Glu Lys Asp Leu Ala Glu Lys Arg Ala Lys Leu Leu 
    210                 215                 220                 


Glu Glu Met Asp Gln Glu Phe Gly Val Ser Thr Leu Val Glu Glu Glu 
225                 230                 235                 240 


Phe Gly Gln Arg Arg Gln Asp Leu Tyr Ser Ala Arg Asp Leu Gln Gly 
                245                 250                 255     


Leu Thr Val Glu His Ala Ile Asp Ser Phe Arg Glu Gly Glu Thr Met 
            260                 265                 270         


Ile Leu Thr Leu Lys Asp Lys Gly Val Leu Gln Glu Glu Glu Asp Val 
        275                 280                 285             


Leu Val Asn Val Asn Leu Val Asp Lys Glu Arg Ala Glu Lys Asn Val 
    290                 295                 300                 


Glu Leu Arg Lys Lys Lys Pro Asp Tyr Leu Pro Tyr Ala Glu Asp Glu 
305                 310                 315                 320 


Ser Val Asp Asp Leu Ala Gln Gln Lys Pro Arg Ser Ile Leu Ser Lys 
                325                 330                 335     


Tyr Asp Glu Glu Leu Glu Gly Glu Arg Pro His Ser Phe Arg Leu Glu 
            340                 345                 350         


Gln Gly Gly Thr Ala Asp Gly Leu Arg Glu Arg Glu Leu Glu Glu Ile 
        355                 360                 365             


Arg Ala Lys Leu Arg Leu Gln Ala Gln Ser Leu Ser Thr Val Gly Pro 
    370                 375                 380                 


Arg Leu Ala Ser Glu Tyr Leu Thr Pro Glu Glu Met Val Thr Phe Lys 
385                 390                 395                 400 


Lys Thr Lys Arg Arg Val Lys Lys Ile Arg Lys Lys Glu Lys Glu Val 
                405                 410                 415     


Val Val Arg Ala Asp Asp Leu Leu Pro Leu Gly Asp Gln Thr Gln Asp 
            420                 425                 430         


Gly Asp Phe Gly Ser Arg Leu Arg Gly Arg Gly Arg Arg Arg Val Ser 
        435                 440                 445             


Glu Val Glu Glu Glu Lys Glu Pro Val Pro Gln Pro Leu Pro Ser Asp 
    450                 455                 460                 


Asp Thr Arg Val Glu Asn Met Asp Ile Ser Asp Glu Glu Glu Gly Gly 
465                 470                 475                 480 


Ala Pro Pro Pro Gly Ser Pro Gln Val Leu Glu Glu Asp Glu Ala Glu 
                485                 490                 495     


Leu Glu Leu Gln Lys Gln Leu Glu Lys Gly Arg Arg Leu Arg Gln Leu 
            500                 505                 510         


Gln Gln Leu Gln Gln Leu Arg Asp Ser Gly Glu Lys Val Val Glu Ile 
        515                 520                 525             


Val Lys Lys Leu Glu Ser Arg Gln Arg Gly Trp Glu Glu Asp Glu Asp 
    530                 535                 540                 


Pro Glu Arg Lys Gly Ala Ile Val Phe Asn Ala Thr Ser Glu Phe Cys 
545                 550                 555                 560 


Arg Thr Leu Gly Glu Ile Pro Thr Tyr Gly Leu Ala Gly Asn Arg Glu 
                565                 570                 575     


Glu Gln Glu Glu Leu Met Asp Phe Glu Arg Asp Glu Glu Arg Ser Ala 
            580                 585                 590         


Asn Gly Gly Ser Glu Ser Asp Gly Glu Glu Asn Ile Gly Trp Ser Thr 
        595                 600                 605             


Val Asn Leu Asp Glu Glu Lys Gln Gln Gln Asp Phe Ser Ala Ser Ser 
    610                 615                 620                 


Thr Thr Ile Leu Asp Glu Glu Pro Ile Val Asn Arg Gly Leu Ala Ala 
625                 630                 635                 640 


Ala Leu Leu Leu Cys Gln Asn Lys Gly Leu Leu Glu Thr Thr Val Gln 
                645                 650                 655     


Lys Val Ala Arg Val Lys Ala Pro Asn Lys Ser Leu Pro Ser Ala Val 
            660                 665                 670         


Tyr Cys Ile Glu Asp Lys Met Ala Ile Asp Asp Lys Tyr Ser Arg Arg 
        675                 680                 685             


Glu Glu Tyr Arg Gly Phe Thr Gln Asp Phe Lys Glu Lys Asp Gly Tyr 
    690                 695                 700                 


Lys Pro Asp Val Lys Ile Glu Tyr Val Asp Glu Thr Gly Arg Lys Leu 
705                 710                 715                 720 


Thr Pro Lys Glu Ala Phe Arg Gln Leu Ser His Arg Phe His Gly Lys 
                725                 730                 735     


Gly Ser Gly Lys Met Lys Thr Glu Arg Arg Met Lys Lys Leu Asp Glu 
            740                 745                 750         


Glu Ala Leu Leu Lys Lys Met Ser Ser Ser Asp Thr Pro Leu Gly Thr 
        755                 760                 765             


Val Ala Leu Leu Gln Glu Lys Gln Lys Ala Gln Lys Thr Pro Tyr Ile 
    770                 775                 780                 


Val Leu Ser Gly Ser Gly Lys Ser Met Asn Ala Asn Thr Ile Thr Lys 
785                 790                 795                 800 






<210>  3381
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SART-_1__Homo_sapiens__AAH01058

<400>  3381
auggggucgu ccaagaagca ucgcggagag aaggaggcgg ccgggacgac ggcggcggcc       60

ggcaccgggg gugccaccga gcagccgccg cggcaccggg aacacaaaaa acacaagcac      120

cggaguggcg gcaguggcgg uagcgguggc gaacgacgga agcggagccg ggaacguggg      180

ggcgagcgcg ggagcgggcg gcgcggggcc gaagcugagg cccggagcag cacgcacggg      240

cgggagcgca gccaggcaga gcccuccgag cggcgcguga agcgggagaa gcgcgaugac      300

ggcuacgagg ccgcugccag cuccaaaacu agcucaggcg augccuccuc acucagcauc      360

gaggagacua acaaacuccg ggcaaaguug gggcugaaac ccuuggaggu uaaugccauc      420

aagaaggagg cgggcaccaa ggaggagccc gugacagcug augucaucaa cccuauggcc      480

uugcgacagc gagaggagcu gcgggagaag cuggcagcug ccaaggagaa gcgccugcug      540

aaccaaaagc uggggaagau aaagacccua ggagaggaug accccuggcu ggacgacacu      600

gcagccugga ucgagaggag ccggcagcug cagaaggaga aggaccuggc agagaagagg      660

gccaaguuac uggaggagau ggaccaagag uuugguguca gcacucuggu ggaggaggag      720

uucgggcaga ggcggcagga ccuguacagu gcccgggacc ugcagggccu caccguggag      780

caugccauug auuccuuccg agaaggggag acaaugauuc uuacccucaa ggacaaaggc      840

gugcugcagg aggaggagga cgugcuggug aacgugaacc ugguggauaa ggagcgggca      900

gagaaaaaug uggagcugcg gaagaagaag ccugacuacc ugcccuaugc cgaggacgag      960

agcguggacg accuggcgca gcaaaaaccu cgcucuaucc uguccaagua ugacgaagag     1020

cuugaagggg agcggccaca uuccuuccgc uuggagcagg gcggcacggc ugauggccug     1080

cgggagcggg agcuggagga gauccgggcc aagcugcggc ugcaggcuca gucccugagc     1140

acaguggggc cccggcuggc cuccgaauac cucacgccug aggagauggu gaccuuuaaa     1200

aagaccaagc ggagggugaa gaaaauccgc aagaaggaga aggagguagu agugcgggca     1260

gaugacuugc ugccucucgg ggaccagacu caggaugggg acuuugguuc cagacugcgg     1320

ggacgggguc gccgccgagu guccgaagug gaggaggaga aggagccugu gccucagccc     1380

cugccgucgg acgacacccg aguggagaac auggacauca gugaugagga ggaaggugga     1440

gcuccaccgc cggggucccc gcaggugcug gaggaggacg aggcggagcu ggagcugcag     1500

aagcagcugg agaagggacg ccggcugcga caguuacagc agcuacagca gcugcgagac     1560

aguggcgaga agguggugga gauugugaag aagcuggagu cucgccagcg gggcugggag     1620

gaggaugagg aucccgagcg gaagggggcc aucguguuca acgccacguc cgaguucugc     1680

cgcaccuugg gggagauccc caccuacggg cuggcuggca aucgcgagga gcaggaggag     1740

cucauggacu uugaacggga ugaggagcgc ucagccaacg guggcuccga aucugacggg     1800

gaggagaaca ucggcuggag cacggugaac cuggacgagg agaagcagca gcaggauuuc     1860

ucugcuuccu ccaccaccau ccuggacgag gaaccgaucg ugaauagggg gcuggcagcu     1920

gcccugcucc ugugucagaa caaagggcug cuggagacca cagugcagaa gguggcccgg     1980

gugaaggccc ccaacaaguc gcugcccuca gccguguacu gcaucgagga uaagauggcc     2040

aucgaugaca aguacagccg gagggaggaa uaccgaggcu ucacacagga cuucaaggag     2100

aaggacggcu acaaacccga cguuaagauc gaauacgugg augagacggg ccggaaacuc     2160

acacccaagg aggcuuuccg gcagcugucg caccgcuucc auggcaaggg cucaggcaag     2220

augaagacag agcggcggau gaagaagcug gacgaggagg cgcuccugaa gaagaugagc     2280

uccagcgaca cgccccuggg caccguggcc cugcuccagg agaagcagaa ggcucagaag     2340

acccccuaca ucgugcucag cggcagcggc aagagcauga acgcgaacac caucaccaag     2400

uga                                                                   2403


<210>  3382
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SART-_1__Homo_sapiens__AAH01058

<400>  3382
augggcagcu ccaagaagca ccgcggggag aaggaggccg ccggcaccac cgcggccgcc       60

gggacgggcg gggccaccga gcagcccccg cggcaccgcg agcacaagaa gcacaagcac      120

cggagcggcg gcuccggggg cagcgggggc gagcgccgga agcgcucccg ggagcgcggg      180

ggcgagcggg gcagcgggcg ccggggcgcc gaggcggagg cccgcuccag cacccacggg      240

cgggagcgcu cccaggccga gcccagcgag cggcgcguga agcgggagaa gcgcgacgac      300

ggcuacgagg ccgcggccuc cagcaagacc uccagcggcg acgccuccag ccuguccauc      360

gaggagacga acaagcuccg ggccaagcug gggcugaagc cccucgaggu caacgccauc      420

aagaaggagg cgggcaccaa ggaggagccc gugaccgccg acgugaucaa cccgauggcc      480

cugcgccagc gggaggagcu gcgcgagaag cucgccgccg cgaaggagaa gcgccugcug      540

aaccagaagc ucgggaagau caagacccug ggcgaggacg accccuggcu ggacgacacg      600

gccgccugga ucgagcggag ccgccagcuc cagaaggaga aggaccuggc cgagaagcgg      660

gccaagcugc ucgaggagau ggaccaggag uucggggucu ccacccuggu ggaggaggag      720

uucggccagc gccggcagga ccuguacagc gcgcgcgacc uccagggccu gaccguggag      780

cacgccaucg acagcuuccg ggagggggag accaugaucc ugacgcucaa ggacaagggc      840

guccugcagg aggaggagga cgugcuggug aacgucaacc ucguggacaa ggagcgcgcc      900

gagaagaacg uggagcugcg gaagaagaag cccgacuacc ugcccuacgc cgaggacgag      960

uccgucgacg accucgccca gcagaagccg cgcagcaucc uguccaagua cgacgaggag     1020

cuggaggggg agcggcccca cagcuuccgc cucgagcagg gcgggaccgc ggacggccug     1080

cgggagcgcg agcuggagga gauccgggcc aagcuccgcc ugcaggccca gucccugagc     1140

accgugggcc cccggcucgc cuccgaguac cugacccccg aggagauggu gacguucaag     1200

aagaccaagc gccgggucaa gaagauccgc aagaaggaga aggagguggu gguccgcgcg     1260

gacgaccugc ucccgcuggg ggaccagacc caggacggcg acuucgggag ccggcugcgc     1320

ggccgggggc gccggcgcgu guccgaggug gaggaggaga aggagcccgu cccccagccc     1380

cucccgagcg acgacacccg gguggagaac auggacaucu ccgacgagga ggagggcggc     1440

gccccgccgc ccgggagccc ccaggugcug gaggaggacg aggccgagcu ggagcuccag     1500

aagcagcugg agaagggccg ccggcugcgc cagcuccagc agcugcagca gcugcgggac     1560

uccggggaga aggucgugga gaucgucaag aagcuggaga gccgccagcg gggcugggag     1620

gaggacgagg accccgagcg caagggcgcc aucguguuca acgccacguc cgaguucugc     1680

cggacccucg gggagauccc caccuacggc cuggcgggga accgcgagga gcaggaggag     1740

cugauggacu ucgagcggga cgaggagcgc agcgccaacg gcggguccga gagcgacggc     1800

gaggagaaca ucggcugguc caccgugaac cucgacgagg agaagcagca gcaggacuuc     1860

agcgccagcu ccacgaccau ccuggacgag gagcccaucg ucaaccgggg gcuggccgcc     1920

gcgcuccugc ugugccagaa caagggccuc cuggagacca ccgugcagaa gguggcccgc     1980

gucaaggccc ccaacaagag ccugcccucc gccguguacu gcaucgagga caagauggcc     2040

aucgacgaca aguacagccg gcgcgaggag uaccgcgggu ucacgcagga cuucaaggag     2100

aaggacggcu acaagcccga cgugaagauc gaguacgucg acgagaccgg gcggaagcuc     2160

acccccaagg aggcguuccg ccagcugucc caccgguucc acggcaaggg cagcgggaag     2220

augaagaccg agcgccggau gaagaagcug gacgaggagg cccuccugaa gaagaugucc     2280

agcuccgaca cgccgcuggg caccguggcc cuccugcagg agaagcagaa ggcccagaag     2340

acccccuaca ucgugcugag cggguccggc aagagcauga acgcgaacac caucacgaag     2400

uga                                                                   2403


<210>  3383
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SART-_1__Homo_sapiens__AAH01058

<400>  3383
augggcuccu ccaagaagca ccgcggcgag aaggaggccg ccggcaccac cgccgccgcc       60

ggcaccggcg gcgccaccga gcagcccccc cgccaccgcg agcacaagaa gcacaagcac      120

cgcuccggcg gcuccggcgg cuccggcggc gagcgccgca agcgcucccg cgagcgcggc      180

ggcgagcgcg gcuccggccg ccgcggcgcc gaggccgagg cccgcuccuc cacccacggc      240

cgcgagcgcu cccaggccga gcccuccgag cgccgcguca agcgcgagaa gcgcgacgac      300

ggcuacgagg ccgccgccuc cuccaagacc uccuccggcg acgccuccuc ccucuccauc      360

gaggagacca acaagcuccg cgccaagcuc ggccucaagc cccucgaggu caacgccauc      420

aagaaggagg ccggcaccaa ggaggagccc gucaccgccg acgucaucaa ccccauggcc      480

cuccgccagc gcgaggagcu ccgcgagaag cucgccgccg ccaaggagaa gcgccuccuc      540

aaccagaagc ucggcaagau caagacccuc ggcgaggacg accccuggcu cgacgacacc      600

gccgccugga ucgagcgcuc ccgccagcuc cagaaggaga aggaccucgc cgagaagcgc      660

gccaagcucc ucgaggagau ggaccaggag uucggcgucu ccacccucgu cgaggaggag      720

uucggccagc gccgccagga ccucuacucc gcccgcgacc uccagggccu caccgucgag      780

cacgccaucg acuccuuccg cgagggcgag accaugaucc ucacccucaa ggacaagggc      840

guccuccagg aggaggagga cguccucguc aacgucaacc ucgucgacaa ggagcgcgcc      900

gagaagaacg ucgagcuccg caagaagaag cccgacuacc uccccuacgc cgaggacgag      960

uccgucgacg accucgccca gcagaagccc cgcuccaucc ucuccaagua cgacgaggag     1020

cucgagggcg agcgccccca cuccuuccgc cucgagcagg gcggcaccgc cgacggccuc     1080

cgcgagcgcg agcucgagga gauccgcgcc aagcuccgcc uccaggccca gucccucucc     1140

accgucggcc cccgccucgc cuccgaguac cucacccccg aggagauggu caccuucaag     1200

aagaccaagc gccgcgucaa gaagauccgc aagaaggaga aggaggucgu cguccgcgcc     1260

gacgaccucc ucccccucgg cgaccagacc caggacggcg acuucggcuc ccgccuccgc     1320

ggccgcggcc gccgccgcgu cuccgagguc gaggaggaga aggagcccgu cccccagccc     1380

cuccccuccg acgacacccg cgucgagaac auggacaucu ccgacgagga ggagggcggc     1440

gccccccccc ccggcucccc ccagguccuc gaggaggacg aggccgagcu cgagcuccag     1500

aagcagcucg agaagggccg ccgccuccgc cagcuccagc agcuccagca gcuccgcgac     1560

uccggcgaga aggucgucga gaucgucaag aagcucgagu cccgccagcg cggcugggag     1620

gaggacgagg accccgagcg caagggcgcc aucgucuuca acgccaccuc cgaguucugc     1680

cgcacccucg gcgagauccc caccuacggc cucgccggca accgcgagga gcaggaggag     1740

cucauggacu ucgagcgcga cgaggagcgc uccgccaacg gcggcuccga guccgacggc     1800

gaggagaaca ucggcugguc caccgucaac cucgacgagg agaagcagca gcaggacuuc     1860

uccgccuccu ccaccaccau ccucgacgag gagcccaucg ucaaccgcgg ccucgccgcc     1920

gcccuccucc ucugccagaa caagggccuc cucgagacca ccguccagaa ggucgcccgc     1980

gucaaggccc ccaacaaguc ccuccccucc gccgucuacu gcaucgagga caagauggcc     2040

aucgacgaca aguacucccg ccgcgaggag uaccgcggcu ucacccagga cuucaaggag     2100

aaggacggcu acaagcccga cgucaagauc gaguacgucg acgagaccgg ccgcaagcuc     2160

acccccaagg aggccuuccg ccagcucucc caccgcuucc acggcaaggg cuccggcaag     2220

augaagaccg agcgccgcau gaagaagcuc gacgaggagg cccuccucaa gaagaugucc     2280

uccuccgaca ccccccucgg caccgucgcc cuccuccagg agaagcagaa ggcccagaag     2340

acccccuaca ucguccucuc cggcuccggc aaguccauga acgccaacac caucaccaag     2400

uga                                                                   2403


<210>  3384
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SART-_1__Homo_sapiens__AAH01058

<400>  3384
augggcagcu ccaagaaaca cagaggggag aaggaagccg cuggaaccac agcagccgcg       60

gguacuggcg gggcuacgga gcagcccccu aggcaucggg aacacaaaaa gcauaaacac      120

cgcucuggag gcucaggugg gaguggaggc gagcgacgua agagaagcag ggaacggggc      180

ggggagcgcg gauccgguag aaggggcgcc gaggcagaag cccggucuuc gacccauggg      240

cgcgagcgau cacaagcuga accaagcgag agaaggguga agcgggagaa acgugacgau      300

ggauacgaag cagccgcuag uuccaagaca ucuagcggcg acgccuccuc acugaguauc      360

gaggaaacua acaaacuccg cgcgaaacuu ggucugaaac cguuggaggu caaugcaauu      420

aagaaggaag ccgggaccaa agaggagccc guuacagcug augugauaaa cccuauggcc      480

uuaagacaga gggaagaacu gcgggaaaag cuagcagcug ccaaagagaa gcgacuccug      540

aaucagaaac uuggaaagau caaaacccug ggcgaagacg auccaugguu ggacgauacu      600

gcggccugga uugagcgcag cagacagcuc caaaaggaga aggaccuggc agaaaagagg      660

gcuaagcugc ucgaggaaau ggaucaggag uucggcguau cuacauuagu ggaagaggag      720

uuugggcagc ggcgccagga ccuguauucc gccagagauc uucaaggauu gaccgucgaa      780

cacgcuaucg acucauucag ggagggugaa acgaugauuc ugacucuaaa agauaagggc      840

gugcuccagg aggaggaaga cguucuggug aacgucaauc uuguggacaa agagcgugcc      900

gaaaagaacg uagagcugcg gaagaaaaag cccgauuacu ugccuuaugc agaagacgag      960

agcguugaug accucgccca gcagaaacca cgaaguaucc ugucuaagua cgaugaggaa     1020

uuagaggggg aaagacccca cuccuuuagg cuggagcaag gaggcaccgc ugacggucuc     1080

cgcgaacggg agcuugagga aauaagagcg aaacugaggu ugcaggcaca gagccuaucg     1140

acaguggggc cucgccuggc cucugaguau cucacuccag aagagauggu caccuucaag     1200

aagacaaaac gacgggugaa gaaaauccgu aagaaagaaa aggagguggu cguuagagcu     1260

gaugaccugc uuccgcuggg cgaucaaacc caggacggag auuuuggcuc cagguugcgc     1320

gggcggggaa gaaggcgagu gucagaggua gaagaggaaa aggagcccgu gccucagcca     1380

cuccccagug acgacacgcg cgucgagaau auggauauua gcgacgaaga ggaagguggc     1440

gccccuccac ccgggucccc ucaggugcug gaggaagaug aggcagaguu agaacugcaa     1500

aaacagcuag agaagggacg gagacucagg cagcugcagc aacuucagca guugcgugac     1560

ucuggcgaaa aaguugugga gaucgucaag aaacuggaaa gccgccagcg ggguugggag     1620

gaggaugaag acccggagag aaagggggcc auuguguuca acgcuacuuc agaauuuugc     1680

aggacacucg gcgagauccc caccuacgga cuggccggca aucgagaaga acaagaggaa     1740

cuuauggauu ucgagcggga cgaggagcgc agugcaaacg ggggauccga gagcgauggu     1800

gaagagaaua uaggcugguc uacuguaaac cuggacgaag agaaacagca gcaggauuuu     1860

ucagcgagua gcacaaccau uuuggacgag gagccaaucg uuaauagagg gcucgcugcc     1920

gcacuguuac ugugucaaaa caagggacua cucgagacga ccgugcagaa ggucgccagg     1980

gugaaagcuc cuaauaaguc ccugcccucu gccgucuauu gcauugaaga uaaaauggca     2040

aucgacgaca aguacucgcg gcgagaggaa uacagaggcu ucacacagga uuuuaaagag     2100

aaggacgguu auaagccaga ugugaaaauc gaauacguug acgagacugg gcgcaaacuu     2160

acccccaagg aggcuuucag gcaauugagc caucguuuuc acggcaaggg auccggcaaa     2220

augaagacag aacggagaau gaagaaacug gaugaggaag cccuccugaa gaaaauguca     2280

aguucugaca cuccuuuagg gaccguggcg cugcuucagg agaagcagaa agcccagaag     2340

acaccauaua uuguauugag cggauccggc aagucaauga acgcuaacac cauaacuaaa     2400

uga                                                                   2403


<210>  3385
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SART-_1__Homo_sapiens__AAH01058

<400>  3385
augggcagca gcaagaagca cagaggcgag aaggaggccg ccggcaccac cgccgccgcc       60

ggcaccggcg gcgccaccga gcagcccccc agacacagag agcacaagaa gcacaagcac      120

agaagcggcg gcagcggcgg cagcggcggc gagagaagaa agagaagcag agagagaggc      180

ggcgagagag gcagcggcag aagaggcgcc gaggccgagg ccagaagcag cacccacggc      240

agagagagaa gccaggccga gcccagcgag agaagaguga agagagagaa gagagacgac      300

ggcuacgagg ccgccgccag cagcaagacc agcagcggcg acgccagcag ccugagcauc      360

gaggagacca acaagcugag agccaagcug ggccugaagc cccuggaggu gaacgccauc      420

aagaaggagg ccggcaccaa ggaggagccc gugaccgccg acgugaucaa ccccauggcc      480

cugagacaga gagaggagcu gagagagaag cuggccgccg ccaaggagaa gagacugcug      540

aaccagaagc ugggcaagau caagacccug ggcgaggacg accccuggcu ggacgacacc      600

gccgccugga ucgagagaag cagacagcug cagaaggaga aggaccuggc cgagaagaga      660

gccaagcugc uggaggagau ggaccaggag uucggcguga gcacccuggu ggaggaggag      720

uucggccaga gaagacagga ccuguacagc gccagagacc ugcagggccu gaccguggag      780

cacgccaucg acagcuucag agagggcgag accaugaucc ugacccugaa ggacaagggc      840

gugcugcagg aggaggagga cgugcuggug aacgugaacc ugguggacaa ggagagagcc      900

gagaagaacg uggagcugag aaagaagaag cccgacuacc ugcccuacgc cgaggacgag      960

agcguggacg accuggccca gcagaagccc agaagcaucc ugagcaagua cgacgaggag     1020

cuggagggcg agagacccca cagcuucaga cuggagcagg gcggcaccgc cgacggccug     1080

agagagagag agcuggagga gaucagagcc aagcugagac ugcaggccca gagccugagc     1140

accgugggcc ccagacuggc cagcgaguac cugacccccg aggagauggu gaccuucaag     1200

aagaccaaga gaagagugaa gaagaucaga aagaaggaga aggagguggu ggugagagcc     1260

gacgaccugc ugccccuggg cgaccagacc caggacggcg acuucggcag cagacugaga     1320

ggcagaggca gaagaagagu gagcgaggug gaggaggaga aggagcccgu gccccagccc     1380

cugcccagcg acgacaccag aguggagaac auggacauca gcgacgagga ggagggcggc     1440

gccccccccc ccggcagccc ccaggugcug gaggaggacg aggccgagcu ggagcugcag     1500

aagcagcugg agaagggcag aagacugaga cagcugcagc agcugcagca gcugagagac     1560

agcggcgaga agguggugga gaucgugaag aagcuggaga gcagacagag aggcugggag     1620

gaggacgagg accccgagag aaagggcgcc aucguguuca acgccaccag cgaguucugc     1680

agaacccugg gcgagauccc caccuacggc cuggccggca acagagagga gcaggaggag     1740

cugauggacu ucgagagaga cgaggagaga agcgccaacg gcggcagcga gagcgacggc     1800

gaggagaaca ucggcuggag caccgugaac cuggacgagg agaagcagca gcaggacuuc     1860

agcgccagca gcaccaccau ccuggacgag gagcccaucg ugaacagagg ccuggccgcc     1920

gcccugcugc ugugccagaa caagggccug cuggagacca ccgugcagaa gguggccaga     1980

gugaaggccc ccaacaagag ccugcccagc gccguguacu gcaucgagga caagauggcc     2040

aucgacgaca aguacagcag aagagaggag uacagaggcu ucacccagga cuucaaggag     2100

aaggacggcu acaagcccga cgugaagauc gaguacgugg acgagaccgg cagaaagcug     2160

acccccaagg aggccuucag acagcugagc cacagauucc acggcaaggg cagcggcaag     2220

augaagaccg agagaagaau gaagaagcug gacgaggagg cccugcugaa gaagaugagc     2280

agcagcgaca ccccccuggg caccguggcc cugcugcagg agaagcagaa ggcccagaag     2340

acccccuaca ucgugcugag cggcagcggc aagagcauga acgccaacac caucaccaag     2400

uga                                                                   2403


<210>  3386
<211>  2403
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SART-_1__Homo_sapiens__AAH01058

<400>  3386
augggcagcu ccaagaaaca cagaggggag aaggaagccg cuggaaccac agccgcggcu       60

ggcaccgggg gagccacgga gcagcccccu cggcaucgcg aacacaaaaa gcauaaacac      120

agaucuggcg ggagcggagg cuccggcggg gagcggcgca agagaucucg ggaacgcgga      180

ggcgagagag ggagcggacg gcgcggcgcc gaggcugaag ccagauccuc uacacauggg      240

cgggagcgca gccaagcuga accguccgag agacggguga agcgcgagaa aagagacgau      300

ggauacgaag ccgcggccag cucuaagacc uccagcggcg acgcuucuuc ccugagcauc      360

gaggaaacaa acaaacuccg ggccaagcug ggccuuaaac cccuggaggu caaugcuauu      420

aagaaggaag ccgggaccaa agaggagccu guuacagcgg augugaucaa ccccauggcc      480

cucagacagc gcgaagaacu gcgggaaaaa cuugcugccg cuaaagagaa gagacugcuc      540

aaucagaaac ugggaaagau uaaaacccug ggcgaagacg auccuuggcu cgacgauacg      600

gccgccugga ucgagcgcuc ucggcagcug caaaaggaga aggaccuugc ugaaaagaga      660

gcgaagcugc ucgaggaaau ggaucaggag uucggggugu ccacccuggu cgaagaggag      720

uuuggacagc gccggcagga ccuuuauagc gccagagauc ugcaaggccu cacaguggaa      780

cacgcuauug acuccuuccg cgagggggaa accaugaucc ugacacugaa agauaaggga      840

guucuccagg aggaggaaga cgugcugguc aacgugaauc uuguugacaa agagcgggcc      900

gaaaagaacg uggagcugag aaagaaaaag cccgauuacc ucccuuaugc cgaagacgag      960

ucugucgaug accuggcuca gcagaaaccg cgcagcaucc uuuccaagua cgaugaggaa     1020

cuggagggcg aacggcccca cagcuuuaga cucgagcaag gcgggaccgc cgacggacug     1080

cgggaacgcg agcuggagga aauuagagcg aaacuccggc ugcaggcuca gucucuuucc     1140

acggugggcc cuagacuggc cagcgaguau cucacacccg aagagauggu gaccuucaag     1200

aagacaaaac gccgggucaa gaaaaucaga aagaaagaaa aggagguugu ggugcgcgcc     1260

gaugaccugc uuccucuggg ggaucaaacc caggacggag auuuuggcuc uagacuccgg     1320

gggcgcggca gacggcgcgu cagcgaggug gaagaggaaa aggagcccgu uccgcagccu     1380

cugcccuccg acgacaccag aguggagaau auggauauuu cugacgaaga ggaaggaggc     1440

gcuccuccuc ccgggagccc ccagguccug gaggaagaug aggccgagcu cgaacugcaa     1500

aaacagcuug agaagggacg gcgccugaga cagcuccagc aacugcagca gcugcgggac     1560

uccggcgaaa aagugguuga gaucgugaag aaacuugaaa gccgccagag agggugggag     1620

gaggaugaag acccggagcg gaagggagcu auugucuuca acgccacauc ugaauuuugc     1680

agaacgcucg gcgagauccc caccuacggg cuggcgggca aucgcgagga gcaagaggaa     1740

cugauggauu ucgagcggga cgaagagaga uccgccaacg gaggcagcga gucugauggg     1800

gaagagaaua uuggaugguc cacagugaac cucgacgaag agaaacagca gcaggauuuu     1860

agcgcuuccu cuaccacaau ccuggacgag gaaccuaucg ucaaucgcgg ccuugccgcu     1920

gcccugcucc ugugucaaaa caaggggcug cuugagacca cggugcagaa gguugcgcgg     1980

gugaaagccc ccaauaagag ccucccuucc gcugucuauu gcauugaaga uaaaauggcc     2040

aucgacgaca aguacucuag acgcgaggaa uaccggggau ucacacagga uuuuaaagag     2100

aaggacggcu auaagcccga ugugaaaauu gaauacguug acgagaccgg gagaaagcug     2160

accccgaaag aggcuuuccg ccaacugagc caucgguuuc acggcaaggg auccggcaaa     2220

augaagacag aaagacggau gaagaaacuc gaugaggaag cccugcuuaa gaaaaugucu     2280

agcuccgaca ccccucuggg gacaguggcc cuccugcagg agaagcagaa agcucagaag     2340

acgcccuaua ucguccugag cggaucuggc aaguccauga acgcgaacac cauuacaaaa     2400

uga                                                                   2403


<210>  3387
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SART-2__Homo_sapiens__Q9UL01

<400>  3387

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  3388
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SART-2__Homo_sapiens__AAF00087

<400>  3388
augaggacuc acacacgggg ggcucccagu guguuuuuca uauauuugcu uugcuuugug       60

ucagccuaca ucaccgacga gaacccagaa guuaugauuc ccuucaccaa ugccaacuac      120

gacagccauc ccaugcugua cuucuccagg gcagaagugg cggagcugca gcucagggcu      180

gccagcucgc acgagcacau ugcagcccgc cucacggagg cugugcacac gaugcugucc      240

agccccuugg aauaccuccc ucccugggau cccaaggacu acagugcccg cuggaaugaa      300

auuuuuggaa acaacuuggg ugccuuggca auguucugug ugcuguaucc ugagaacauu      360

gaagcccgag acauggccaa agacuacaug gagaggaugg cagcgcagcc uaguugguug      420

gugaaagaug cuccuuggga ugaggucccg cuugcucacu cccugguugg uuuugccacu      480

gcuuaugacu ucuuguacaa cuaccugagc aagacacaac aggagaaguu ucuugaagug      540

auugccaaug ccucagggua uauguaugaa acuucauaca ggagaggaug gggauuucaa      600

uaccugcaca aucaucagcc caccaacugu auggcuuugc ucacgggaag ccuaguccug      660

augaaucaag gauaucuuca agaagccuac uuauggacca aacaaguucu gaccaucaug      720

gagaaaucuc uggucuugcu cagggaggug acggauggcu cccucuauga aggaguugcg      780

uauggcagcu acaccacuag aucacucuuc caauacaugu uucucgucca gaggcacuuc      840

aacaucaacc acuuuggcca uccguggcuu aaacaacacu uugcauuuau guauagaacc      900

auccugccag gguuucaaag gacuguggcu auugcggacu caaauuacaa cugguuuuau      960

gguccagaaa gccaauuagu guuccuugau aaauuuguca ugcguaaugg cagugguaac     1020

uggcuagcug accaaaucag aaggaaccgu gugguggaag guccaggaac accauccaaa     1080

gggcagcgcu ggugcacucu gcacacagaa uuucucuggu augauggcag cuugaaaucg     1140

guuccuccuc cagacuuugg caccccuaca cugcauuauu uugaagacug gggugucgug     1200

acuuauggaa gugcacuacc ugcagaaauc aauagaucuu uccuuuccuu caagucugga     1260

aaacuggggg gacgugcaau auaugacauu guccacagaa acaaauacaa agauuggauc     1320

aaaggaugga gaaauuuuaa ugcagggcau gaacauccug aucaaaacuc auuuacuuuu     1380

gcucccaaug gugugccuuu cauuacugag gcucuguacg ggccaaagua caccuucuuc     1440

aacaauguuu ugauguuuuc cccagcugug ucaaagagcu gcuuuucucc cugggugggu     1500

caggucacag aagacugcuc aucaaaaugg ucuaaauaca agcaugaccu ggcagcuagu     1560

ugucagggga gggugguugc agcagaggag aaaaaugggg ugguuuucau ccgaggagaa     1620

ggugugggag cuuauaaccc ccagcucaac cugaagaaug uucagaggaa ucucauccuc     1680

cuacauccac agcugcuucu ccuuguagac caaauacacc ugggagagga gagucccuug     1740

gagacagcag cgagcuucuu ccauaaugug gauguuccuu uugaggagac ugugguagau     1800

gguguccaug gggcuuucau caggcagaga gauggucucu auaaaaugua cuggauggac     1860

gauacuggcu acagcgagaa agcaaccuuu gccucaguga cauauccucg gggcuauccc     1920

uacaacggga caaacuaugu gaaugucacc augcaccucc gaagucccau caccagggca     1980

gcuuaccucu ucauagggcc aucuauagau guucagagcu ucacugucca cggagacucu     2040

cagcaacugg auguguucau agccaccagc aaacaugccu acgccacaua ccuguggaca     2100

ggugaggcca caggacaguc ugccuuugca caggucauug cugaucguca caaaauucug     2160

uuugaccgga auucagccau caagagcagc auugucccug aggugaagga cuaugcugcu     2220

auuguggaac agaacuugca gcauuuuaaa ccaguguuuc agcugcugga gaagcagaua     2280

cugucccgag uccggaacac agcuagcuuu aggaagacug cugaacgccu gcugagauuu     2340

ucagauaaga gacagacuga ggaggccauu gacaggauuu uugccauauc acagcaacag     2400

cagcagcaaa gcaagucaaa gaaaaaccga agggcaggca aacgcuauaa auuuguggau     2460

gcugucccug auauuuuugc acagauugaa gucaaugaga aaaagauuag acagaaagcu     2520

cagauuuugg cacagaaaga acuacccaua gaugaagaug aagaaaugaa agaccuuuua     2580

gauuuugcag auguaacaua cgagaaacau aaaaaugggg gcuugauuaa aggccgguuu     2640

ggacaggcac ggauggugac aacuacacac agcagggccc caucacuguc ugcuuccuau     2700

accagguugu uccugauucu gaacauugcu auuuucuuug ucauguuggc aaugcaacug     2760

acuuauuucc agagggccca gagccuacau ggccaaagau gucuuuaugc aguucuucuc     2820

auagauagcu guauuuuauu augguuguac ucuucuuguu cccaaucaca guguuag        2877


<210>  3389
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SART-2__Homo_sapiens__AAF00087

<400>  3389
augcgcaccc acacccgggg cgcccccagc guguucuuca ucuaccugcu cugcuucguc       60

uccgccuaca ucacggacga gaacccggag gugaugaucc ccuucaccaa cgcgaacuac      120

gacagccacc ccaugcugua cuucucccgc gccgaggugg ccgagcugca gcuccgggcc      180

gccagcuccc acgagcacau cgcggcccgc cugaccgagg ccguccacac caugcugagc      240

agcccccucg aguaccugcc gcccugggac cccaaggacu acuccgcccg guggaacgag      300

aucuucggga acaaccuggg cgcgcucgcc auguucugcg ugcuguaccc cgagaacauc      360

gaggcccgcg acauggccaa ggacuacaug gagcggaugg ccgcgcagcc guccuggcug      420

gugaaggacg cccccuggga cgaggucccc cucgcccaca gccugguggg guucgccacg      480

gccuacgacu uccuguacaa cuaccucucc aagacccagc aggagaaguu ccuggaggug      540

aucgcgaacg ccagcggcua cauguacgag accuccuacc gccgggggug gggcuuccag      600

uaccugcaca accaccagcc caccaacugc auggcccucc ugacgggcag ccugguccuc      660

augaaccagg gguaccugca ggaggccuac cuguggacca agcagguccu caccaucaug      720

gagaaguccc uggugcugcu ccgcgaggug accgacggca gccuguacga ggggguggcc      780

uacggcuccu acacgacccg gagccuguuc caguacaugu uccucgugca gcgccacuuc      840

aacaucaacc acuucgggca cccguggcug aagcagcacu ucgcguucau guaccggacc      900

auccugcccg gcuuccagcg caccgucgcc aucgccgacu ccaacuacaa cugguucuac      960

ggccccgaga gccagcucgu guuccuggac aaguucguga ugcggaacgg gagcggcaac     1020

uggcuggccg accagauccg ccggaaccgc gucguggagg ggcccggcac gccguccaag     1080

ggccagcggu ggugcacccu ccacaccgag uuccuguggu acgacgggag ccugaagucc     1140

gugcccccgc ccgacuucgg cacccccacg cuccacuacu ucgaggacug gggcgucgug     1200

accuacggga gcgcccugcc cgcggagauc aaccgcuccu uccugagcuu caaguccggg     1260

aagcucggcg gccgggccau cuacgacauc gugcaccgca acaaguacaa ggacuggauc     1320

aagggguggc gcaacuucaa cgccggccac gagcaccccg accagaacag cuucaccuuc     1380

gcccccaacg gggucccguu caucaccgag gcgcuguacg gccccaagua cacguucuuc     1440

aacaacgugc ugauguucuc ccccgccguc agcaaguccu gcuucagccc cugggugggc     1500

caggugaccg aggacugcuc cagcaagugg uccaaguaca agcacgaccu cgccgccagc     1560

ugccaggggc gggucguggc cgcggaggag aagaacggcg uggucuucau ccgcggggag     1620

ggcguggggg ccuacaaccc gcagcugaac cugaagaacg ugcagcggaa ccucauccug     1680

cugcaccccc agcugcuccu gcuggucgac cagauccacc ucggcgagga gagcccccug     1740

gagaccgccg ccuccuucuu ccacaacgug gacgugccgu ucgaggagac cgucguggac     1800

ggggugcacg gcgccuucau ccgccagcgg gacggccugu acaagaugua cuggauggac     1860

gacacggggu acuccgagaa ggcgaccuuc gccagcguca ccuacccccg cggcuacccc     1920

uacaacggga ccaacuacgu gaacgugacg augcaccucc ggagccccau cacccgcgcc     1980

gccuaccugu ucaucggccc guccaucgac guccagagcu ucaccgugca cggcgacucc     2040

cagcagcugg acguguucau cgccaccagc aagcacgcgu acgccacgua ccucuggacc     2100

ggggaggcca ccggccaguc cgccuucgcg caggucaucg ccgaccggca caagauccug     2160

uucgaccgca acagcgccau caaguccagc aucgugcccg aggugaagga cuacgccgcc     2220

aucgucgagc agaaccugca gcacuucaag cccguguucc agcuccugga gaagcagauc     2280

cugucccggg ugcgcaacac cgcgagcuuc cggaagaccg ccgagcgccu ccugcgguuc     2340

uccgacaagc gccagacgga ggaggccauc gaccggaucu ucgccaucag ccagcagcag     2400

cagcagcagu ccaagagcaa gaagaaccgc cgggccggga agcgcuacaa guucgucgac     2460

gcggugcccg acaucuucgc ccagaucgag gugaacgaga agaagauccg ccagaaggcc     2520

cagauccugg cccagaagga gcucccgauc gacgaggacg aggagaugaa ggaccugcug     2580

gacuucgccg acgucaccua cgagaagcac aagaacggcg ggcucaucaa gggccgguuc     2640

ggccaggcgc gcauggugac caccacgcac ucccgggccc ccagccuguc cgccagcuac     2700

acccgccugu uccucauccu gaacaucgcc aucuucuucg ugaugcuggc gaugcagcuc     2760

accuacuucc agcgggccca gagccugcac gggcagcgcu gccuguacgc cguccuccug     2820

aucgacuccu gcauccugcu cuggcuguac agcuccugca gccaguccca gugcuga        2877


<210>  3390
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SART-2__Homo_sapiens__AAF00087

<400>  3390
augcgcaccc acacccgcgg cgcccccucc gucuucuuca ucuaccuccu cugcuucguc       60

uccgccuaca ucaccgacga gaaccccgag gucaugaucc ccuucaccaa cgccaacuac      120

gacucccacc ccaugcucua cuucucccgc gccgaggucg ccgagcucca gcuccgcgcc      180

gccuccuccc acgagcacau cgccgcccgc cucaccgagg ccguccacac caugcucucc      240

uccccccucg aguaccuccc ccccugggac cccaaggacu acuccgcccg cuggaacgag      300

aucuucggca acaaccucgg cgcccucgcc auguucugcg uccucuaccc cgagaacauc      360

gaggcccgcg acauggccaa ggacuacaug gagcgcaugg ccgcccagcc cuccuggcuc      420

gucaaggacg cccccuggga cgaggucccc cucgcccacu cccucgucgg cuucgccacc      480

gccuacgacu uccucuacaa cuaccucucc aagacccagc aggagaaguu ccucgagguc      540

aucgccaacg ccuccggcua cauguacgag accuccuacc gccgcggcug gggcuuccag      600

uaccuccaca accaccagcc caccaacugc auggcccucc ucaccggcuc ccucguccuc      660

augaaccagg gcuaccucca ggaggccuac cucuggacca agcagguccu caccaucaug      720

gagaaguccc ucguccuccu ccgcgagguc accgacggcu cccucuacga gggcgucgcc      780

uacggcuccu acaccacccg cucccucuuc caguacaugu uccucgucca gcgccacuuc      840

aacaucaacc acuucggcca ccccuggcuc aagcagcacu ucgccuucau guaccgcacc      900

auccuccccg gcuuccagcg caccgucgcc aucgccgacu ccaacuacaa cugguucuac      960

ggccccgagu cccagcucgu cuuccucgac aaguucguca ugcgcaacgg cuccggcaac     1020

uggcucgccg accagauccg ccgcaaccgc gucgucgagg gccccggcac ccccuccaag     1080

ggccagcgcu ggugcacccu ccacaccgag uuccucuggu acgacggcuc ccucaagucc     1140

gucccccccc ccgacuucgg cacccccacc cuccacuacu ucgaggacug gggcgucguc     1200

accuacggcu ccgcccuccc cgccgagauc aaccgcuccu uccucuccuu caaguccggc     1260

aagcucggcg gccgcgccau cuacgacauc guccaccgca acaaguacaa ggacuggauc     1320

aagggcuggc gcaacuucaa cgccggccac gagcaccccg accagaacuc cuucaccuuc     1380

gcccccaacg gcguccccuu caucaccgag gcccucuacg gccccaagua caccuucuuc     1440

aacaacgucc ucauguucuc ccccgccguc uccaaguccu gcuucucccc cugggucggc     1500

caggucaccg aggacugcuc cuccaagugg uccaaguaca agcacgaccu cgccgccucc     1560

ugccagggcc gcgucgucgc cgccgaggag aagaacggcg ucgucuucau ccgcggcgag     1620

ggcgucggcg ccuacaaccc ccagcucaac cucaagaacg uccagcgcaa ccucauccuc     1680

cuccaccccc agcuccuccu ccucgucgac cagauccacc ucggcgagga guccccccuc     1740

gagaccgccg ccuccuucuu ccacaacguc gacguccccu ucgaggagac cgucgucgac     1800

ggcguccacg gcgccuucau ccgccagcgc gacggccucu acaagaugua cuggauggac     1860

gacaccggcu acuccgagaa ggccaccuuc gccuccguca ccuacccccg cggcuacccc     1920

uacaacggca ccaacuacgu caacgucacc augcaccucc gcucccccau cacccgcgcc     1980

gccuaccucu ucaucggccc cuccaucgac guccaguccu ucaccgucca cggcgacucc     2040

cagcagcucg acgucuucau cgccaccucc aagcacgccu acgccaccua ccucuggacc     2100

ggcgaggcca ccggccaguc cgccuucgcc caggucaucg ccgaccgcca caagauccuc     2160

uucgaccgca acuccgccau caaguccucc aucguccccg aggucaagga cuacgccgcc     2220

aucgucgagc agaaccucca gcacuucaag cccgucuucc agcuccucga gaagcagauc     2280

cucucccgcg uccgcaacac cgccuccuuc cgcaagaccg ccgagcgccu ccuccgcuuc     2340

uccgacaagc gccagaccga ggaggccauc gaccgcaucu ucgccaucuc ccagcagcag     2400

cagcagcagu ccaaguccaa gaagaaccgc cgcgccggca agcgcuacaa guucgucgac     2460

gccguccccg acaucuucgc ccagaucgag gucaacgaga agaagauccg ccagaaggcc     2520

cagauccucg cccagaagga gcuccccauc gacgaggacg aggagaugaa ggaccuccuc     2580

gacuucgccg acgucaccua cgagaagcac aagaacggcg gccucaucaa gggccgcuuc     2640

ggccaggccc gcauggucac caccacccac ucccgcgccc ccucccucuc cgccuccuac     2700

acccgccucu uccucauccu caacaucgcc aucuucuucg ucaugcucgc caugcagcuc     2760

accuacuucc agcgcgccca gucccuccac ggccagcgcu gccucuacgc cguccuccuc     2820

aucgacuccu gcauccuccu cuggcucuac uccuccugcu cccaguccca gugcuga        2877


<210>  3391
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SART-2__Homo_sapiens__AAF00087

<400>  3391
augagaaccc acacaagggg cgcccccagc guguucuuua ucuaccugcu cugcuucguc       60

uccgcuuaua uuacugacga gaacccugaa guuaugauac cauuuacgaa ugcaaacuac      120

gauucucauc cgaugcuuua uuucucacgg gccgaggugg cggaacugca guugcgcgcu      180

gccaguagcc acgagcauau cgcagcccga uuaaccgaag cuguacacac aaugcugucc      240

ucuccccuag aguaccuccc uccaugggac cccaaggauu auucggcacg uuggaaugag      300

auuuuuggga acaaucuggg agcccuugcu auguucugug ugcuguaccc ugaaaacauc      360

gaggccagag acauggcgaa agauuauaug gaaaggaugg cagcccaacc aucaugguug      420

gucaaggacg cucccuggga ugaggugccu cucgcccaua gccugguugg uuuugcaacu      480

gcuuacgacu uccuguacaa uuaucucagu aaaacccagc aggagaaguu uuuagaagug      540

auugccaacg cguccggcua cauguaugag acaucuuacc ggcgcgggug gggauuccag      600

uaucugcaca aucaccaacc aaccaacugc auggcccuuu ugacuggcag ccugguccua      660

augaaucagg guuaccucca ggaagcauau cuguggacaa aacaggugcu uaccaucaug      720

gagaaguccc ugguauugcu cagagaaguu acggaugggu cacuguacga gggaguggcu      780

uacggcaguu auacuaccag gagcuuauuu caauacaugu uccuggucca gcggcauuuu      840

aacauaaauc acuucggcca uccguggcuc aagcagcacu ucgccuuuau guaucgcaca      900

auccuucccg gguuccagcg aacuguggcu auugccgacu cuaacuacaa uugguuuuau      960

ggaccugagu cccaacuggu guucuuggau aaauuuguca ugagaaacgg uucaggcaac     1020

uggcuagcag accagaucag gcggaaucgu guuguggaag ggccaggaac ccccagcaag     1080

ggccagcgcu gguguacacu gcacaccgag uuccucuggu acgaugguag ucugaaaucu     1140

guaccuccac ccgacuuugg gacgccgacu cuucauuauu ucgaagacug gggagugguc     1200

acauacggcu ccgcccugcc ugcugagauu aacagaucgu uuuugagcuu caagucuggc     1260

aaacucgggg gaagggcgau cuacgauaua gugcaccgga auaaguauaa ggacuggauu     1320

aaagguuggc gaaacuuuaa ugcaggccau gaacaccccg aucaaaacuc cuucaccuuu     1380

gccccaaaug ggguuccuuu caucacugag gcucuguacg gacccaagua uacauucuuu     1440

aacaaugugu uaauguucuc accagccguc aguaaaagcu gcuuuucccc cugggugggc     1500

cagguaaccg aggacuguuc uagcaagugg ucaaaauaca agcaugaucu ggcagccagu     1560

ugccaggguc gcguuguggc ugccgaagag aaaaacgggg ucguguucau uagaggcgaa     1620

ggagucggcg cauauaaucc ucagcuaaac cucaagaaug ugcaaaggaa ccugauccuu     1680

uugcacccac agcugcuccu gcuuguugac cagauccacc ugggggagga auccccguug     1740

gagacggcgg cuagcuuuuu ccauaaugug gauguacccu uugaggaaac cgucguggac     1800

ggaguucacg gugccuucau ucggcagcgc gauggccucu acaagaugua uuggauggac     1860

gauacagggu acucugagaa agcaacuuuu gccucaguga ccuacccuag aggauaucca     1920

uacaacggca caaacuaugu caaugugacu augcaucuga ggagucccau aacccgugcu     1980

gccuacuuau ucaucggucc uagcauugac guacaauccu uuacagugca cggggacucu     2040

cagcagcugg auguuuucau cgcaaccucg aagcacgcuu augccacuua ccuauggacg     2100

ggcgaagcga caggacagag cgccuuugcu caagucauag cagaccggca uaaaauucuc     2160

uucgaucgaa acuccgccau caagucaagu aucgugccag aggugaaaga cuaugcugcc     2220

auugucgagc agaaucugca gcacuucaag cccguuuuuc agcuuuugga aaagcaaauc     2280

cugucuagag ugaggaacac cgcgagcuuc cgcaaaacug cagagcggcu ccugagauuu     2340

uccgauaaga ggcagaccga agaggccauu gaccgcauau ucgcuaucuc acagcaacag     2400

cagcagcaaa gcaaaucuaa gaaaaaucga cgggccggca agcguuacaa guuuguggau     2460

gcaguaccgg acauuuucgc ucagaucgaa gucaacgaga aaaagaucag acagaaagcc     2520

cagauuuuag cacaaaagga gcugccuaua gaugaagacg aggaaaugaa agaucuuuug     2580

gacuuugccg augugacaua cgagaagcau aagaaugggg gacucaucaa agguagguuc     2640

ggccaggcuc gcaugguuac cacuacacac ucccgggcgc caagucugag cgccucuuau     2700

acgagacuau uucugauucu caacaucgca auuuucuuug ugaugcuggc uaugcagcuu     2760

accuacuucc agagggccca auccuugcau gggcagcgau gucuguaugc cgucuuacuc     2820

aucgacucau gcauacugcu uuggcuguac aguagcuguu cgcaguccca augcuga        2877


<210>  3392
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SART-2__Homo_sapiens__AAF00087

<400>  3392
augagaaccc acaccagagg cgcccccagc guguucuuca ucuaccugcu gugcuucgug       60

agcgccuaca ucaccgacga gaaccccgag gugaugaucc ccuucaccaa cgccaacuac      120

gacagccacc ccaugcugua cuucagcaga gccgaggugg ccgagcugca gcugagagcc      180

gccagcagcc acgagcacau cgccgccaga cugaccgagg ccgugcacac caugcugagc      240

agcccccugg aguaccugcc ccccugggac cccaaggacu acagcgccag auggaacgag      300

aucuucggca acaaccuggg cgcccuggcc auguucugcg ugcuguaccc cgagaacauc      360

gaggccagag acauggccaa ggacuacaug gagagaaugg ccgcccagcc cagcuggcug      420

gugaaggacg cccccuggga cgaggugccc cuggcccaca gccugguggg cuucgccacc      480

gccuacgacu uccuguacaa cuaccugagc aagacccagc aggagaaguu ccuggaggug      540

aucgccaacg ccagcggcua cauguacgag accagcuaca gaagaggcug gggcuuccag      600

uaccugcaca accaccagcc caccaacugc auggcccugc ugaccggcag ccuggugcug      660

augaaccagg gcuaccugca ggaggccuac cuguggacca agcaggugcu gaccaucaug      720

gagaagagcc uggugcugcu gagagaggug accgacggca gccuguacga gggcguggcc      780

uacggcagcu acaccaccag aagccuguuc caguacaugu uccuggugca gagacacuuc      840

aacaucaacc acuucggcca ccccuggcug aagcagcacu ucgccuucau guacagaacc      900

auccugcccg gcuuccagag aaccguggcc aucgccgaca gcaacuacaa cugguucuac      960

ggccccgaga gccagcuggu guuccuggac aaguucguga ugagaaacgg cagcggcaac     1020

uggcuggccg accagaucag aagaaacaga gugguggagg gccccggcac ccccagcaag     1080

ggccagagau ggugcacccu gcacaccgag uuccuguggu acgacggcag ccugaagagc     1140

gugccccccc ccgacuucgg cacccccacc cugcacuacu ucgaggacug gggcguggug     1200

accuacggca gcgcccugcc cgccgagauc aacagaagcu uccugagcuu caagagcggc     1260

aagcugggcg gcagagccau cuacgacauc gugcacagaa acaaguacaa ggacuggauc     1320

aagggcugga gaaacuucaa cgccggccac gagcaccccg accagaacag cuucaccuuc     1380

gcccccaacg gcgugcccuu caucaccgag gcccuguacg gccccaagua caccuucuuc     1440

aacaacgugc ugauguucag ccccgccgug agcaagagcu gcuucagccc cugggugggc     1500

caggugaccg aggacugcag cagcaagugg agcaaguaca agcacgaccu ggccgccagc     1560

ugccagggca gagugguggc cgccgaggag aagaacggcg ugguguucau cagaggcgag     1620

ggcgugggcg ccuacaaccc ccagcugaac cugaagaacg ugcagagaaa ccugauccug     1680

cugcaccccc agcugcugcu gcugguggac cagauccacc ugggcgagga gagcccccug     1740

gagaccgccg ccagcuucuu ccacaacgug gacgugcccu ucgaggagac cgugguggac     1800

ggcgugcacg gcgccuucau cagacagaga gacggccugu acaagaugua cuggauggac     1860

gacaccggcu acagcgagaa ggccaccuuc gccagcguga ccuaccccag aggcuacccc     1920

uacaacggca ccaacuacgu gaacgugacc augcaccuga gaagccccau caccagagcc     1980

gccuaccugu ucaucggccc cagcaucgac gugcagagcu ucaccgugca cggcgacagc     2040

cagcagcugg acguguucau cgccaccagc aagcacgccu acgccaccua ccuguggacc     2100

ggcgaggcca ccggccagag cgccuucgcc caggugaucg ccgacagaca caagauccug     2160

uucgacagaa acagcgccau caagagcagc aucgugcccg aggugaagga cuacgccgcc     2220

aucguggagc agaaccugca gcacuucaag cccguguucc agcugcugga gaagcagauc     2280

cugagcagag ugagaaacac cgccagcuuc agaaagaccg ccgagagacu gcugagauuc     2340

agcgacaaga gacagaccga ggaggccauc gacagaaucu ucgccaucag ccagcagcag     2400

cagcagcaga gcaagagcaa gaagaacaga agagccggca agagauacaa guucguggac     2460

gccgugcccg acaucuucgc ccagaucgag gugaacgaga agaagaucag acagaaggcc     2520

cagauccugg cccagaagga gcugcccauc gacgaggacg aggagaugaa ggaccugcug     2580

gacuucgccg acgugaccua cgagaagcac aagaacggcg gccugaucaa gggcagauuc     2640

ggccaggcca gaauggugac caccacccac agcagagccc ccagccugag cgccagcuac     2700

accagacugu uccugauccu gaacaucgcc aucuucuucg ugaugcuggc caugcagcug     2760

accuacuucc agagagccca gagccugcac ggccagagau gccuguacgc cgugcugcug     2820

aucgacagcu gcauccugcu guggcuguac agcagcugca gccagagcca gugcuga        2877


<210>  3393
<211>  2877
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SART-2__Homo_sapiens__AAF00087

<400>  3393
augagaaccc acacacgggg cgcccccagc guguucuuua ucuaccugcu cugcuucguc       60

uccgcuuaua uuacggacga gaacccugaa guuaugaucc cguuuaccaa ugccaacuac      120

gauucucauc ccaugcugua uuucagccgc gcggaggugg cugaacuuca gcugagagcc      180

gccuccucuc acgagcauau ugcugcccgg cucacagaag cugugcacac caugcugagc      240

uccccucuug aguaccugcc cccuugggac cccaaggauu auucugcccg cuggaaugag      300

aucuuuggga acaaucucgg agcgcuggcc auguucugug uccuguaccc ugaaaacauu      360

gaggcuagag acauggccaa agauuauaug gaacggaugg cugcccaacc gagcuggcuc      420

gugaaggacg cgcccuggga ugagguuccu cuggcccauu cccuuguggg cuuugcuaca      480

gccuacgacu uccuguacaa uuaucucagc aaaacccagc aggagaaguu ucuggaaguc      540

aucgcuaacg ccucugggua cauguaugag acauccuacc gcagaggaug gggcuuccag      600

uaucuucaca aucaccaacc caccaacugc auggcccugc ucacggggag ccuggugcug      660

augaaucagg gauaccucca ggaggcuuau cuguggacca aacagguucu uacaaucaug      720

gaaaagucuc uggugcuccu gcgggaaguc accgauggcu cccuuuacga gggcguggcg      780

uacgggagcu auacaacccg cucucuguuu caauacaugu uccucgugca gagacauuuu      840

aacauuaauc acuucggaca uccuuggcug aagcagcacu ucgccuuuau guaucggacg      900

auccugcccg gcuuccagcg cacagucgcu auugccgacu ccaacuacaa uugguuuuau      960

gggccggaga gccaacucgu uuuccuggau aaauuuguga ugagaaacgg auccggcaac     1020

uggcuugccg accagauccg gcgcaauaga guggucgaag ggccuggaac ccccucuaag     1080

ggccagcggu gguguacacu gcacaccgag uuccucuggu acgauggcag ccugaaaucc     1140

gugccuccuc ccgacuuugg gacccccaca cuucauuauu ucgaagacug gggaguugug     1200

acguacggca gcgcucugcc ggccgagauu aacagaucuu uucucuccuu caagagcggg     1260

aaacugggag gccgcgcgau cuacgauauu guccaccgga auaaguauaa ggacuggauc     1320

aaagggugga gaaacuuuaa ugcuggacau gaacaccccg aucaaaacuc uuucaccuuu     1380

gccccuaaug gcgugcccuu caucacagag gcccuguacg gcccuaagua uaccuucuuu     1440

aacaauguuc ucauguucag ccccgcugug uccaaaucuu gcuuuagccc gugggucgga     1500

caggugacag aggacuguuc cagcaagugg ucuaaauaca agcaugaucu ggccgcuucc     1560

ugccaggggc gcgucguggc cgcggaagag aaaaacggcg uuguguucau uagaggggaa     1620

ggagucggcg ccuauaaucc ucagcuuaac cugaagaaug ugcaacggaa ccucauccug     1680

cugcaccccc agcuucuccu gcugguugac cagauucacc ucggggagga aagcccucug     1740

gagaccgcug ccagcuuuuu ccauaaugug gauguccccu uugaggaaac ggugguggac     1800

ggcguucacg gagcuuucau ccgccagcgg gauggccuuu acaagaugua uuggauggac     1860

gauacagggu acuccgagaa agccaccuuu gcgagcguca ccuacccuag aggauauccc     1920

uacaacggca caaacuaugu gaaugugacc augcaucugc gcuccccgau uacacgggcc     1980

gcuuaccucu ucaucgggcc uucuaucgac guccaaucuu uuacggugca cggagacucc     2040

cagcagcugg auguuuucau ugccaccucu aagcacgcuu augccacaua ccuguggacc     2100

ggcgaagcca cagggcagag cgcuuuugcg caagugaucg ccgacagaca uaaaauucuu     2160

uucgaucgca acuccgcuau caagagcucu auuguccccg aggugaaaga cuaugccgcc     2220

aucguugagc agaaucucca gcacuucaag cccguguuuc agcugcugga aaagcaaauc     2280

cucucccggg ucagaaacac cgcuagcuuc cggaaaacgg ccgagcgccu gcuuagauuu     2340

ucugauaagc ggcagaccga agaggcgauu gacagaaucu ucgcuauuuc ccagcaacag     2400

cagcagcaaa gcaaaucuaa gaaaaaucgc cgggccggca agagauacaa guuuguggau     2460

gccguuccug acaucuucgc ucagauugaa gugaacgaga aaaagauccg ccagaaagcc     2520

cagauucugg cgcaaaagga gcucccgauc gaugaagacg aggaaaugaa agaucugcug     2580

gacuuugcug augucacaua cgagaagcau aagaauggag gccuuaucaa agggagauuc     2640

ggacaggccc ggauggugac cacaacccac agccgcgccc ccucccucag cgcuucuuau     2700

acgagacugu uucugauucu caacaucgcc auuuucuuug ugaugcuggc uaugcagcuu     2760

acauacuucc agcgggccca aucccugcau ggccagcgcu gucucuaugc gguccugcug     2820

aucgacagcu gcauucuucu cuggcuguac uccucuugua gccaguccca augcuga        2877


<210>  3394
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SART-3__Homo_sapiens__Q15020

<400>  3394

Met Ala Thr Ala Ala Glu Thr Ser Ala Ser Glu Pro Glu Ala Glu Ser 
1               5                   10                  15      


Lys Ala Gly Pro Lys Ala Asp Gly Glu Glu Asp Glu Val Lys Ala Ala 
            20                  25                  30          


Arg Thr Arg Arg Lys Val Leu Ser Arg Ala Val Ala Ala Ala Thr Tyr 
        35                  40                  45              


Lys Thr Met Gly Pro Ala Trp Asp Gln Gln Glu Glu Gly Val Ser Glu 
    50                  55                  60                  


Ser Asp Gly Asp Glu Tyr Ala Met Ala Ser Ser Ala Glu Ser Ser Pro 
65                  70                  75                  80  


Gly Glu Tyr Glu Trp Glu Tyr Asp Glu Glu Glu Glu Lys Asn Gln Leu 
                85                  90                  95      


Glu Ile Glu Arg Leu Glu Glu Gln Leu Ser Ile Asn Val Tyr Asp Tyr 
            100                 105                 110         


Asn Cys His Val Asp Leu Ile Arg Leu Leu Arg Leu Glu Gly Glu Leu 
        115                 120                 125             


Thr Lys Val Arg Met Ala Arg Gln Lys Met Ser Glu Ile Phe Pro Leu 
    130                 135                 140                 


Thr Glu Glu Leu Trp Leu Glu Trp Leu His Asp Glu Ile Ser Met Ala 
145                 150                 155                 160 


Gln Asp Gly Leu Asp Arg Glu His Val Tyr Asp Leu Phe Glu Lys Ala 
                165                 170                 175     


Val Lys Asp Tyr Ile Cys Pro Asn Ile Trp Leu Glu Tyr Gly Gln Tyr 
            180                 185                 190         


Ser Val Gly Gly Ile Gly Gln Lys Gly Gly Leu Glu Lys Val Arg Ser 
        195                 200                 205             


Val Phe Glu Arg Ala Leu Ser Ser Val Gly Leu His Met Thr Lys Gly 
    210                 215                 220                 


Leu Ala Leu Trp Glu Ala Tyr Arg Glu Phe Glu Ser Ala Ile Val Glu 
225                 230                 235                 240 


Ala Ala Arg Leu Glu Lys Val His Ser Leu Phe Arg Arg Gln Leu Ala 
                245                 250                 255     


Ile Pro Leu Tyr Asp Met Glu Ala Thr Phe Ala Glu Tyr Glu Glu Trp 
            260                 265                 270         


Ser Glu Asp Pro Ile Pro Glu Ser Val Ile Gln Asn Tyr Asn Lys Ala 
        275                 280                 285             


Leu Gln Gln Leu Glu Lys Tyr Lys Pro Tyr Glu Glu Ala Leu Leu Gln 
    290                 295                 300                 


Ala Glu Ala Pro Arg Leu Ala Glu Tyr Gln Ala Tyr Ile Asp Phe Glu 
305                 310                 315                 320 


Met Lys Ile Gly Asp Pro Ala Arg Ile Gln Leu Ile Phe Glu Arg Ala 
                325                 330                 335     


Leu Val Glu Asn Cys Leu Val Pro Asp Leu Trp Ile Arg Tyr Ser Gln 
            340                 345                 350         


Tyr Leu Asp Arg Gln Leu Lys Val Lys Asp Leu Val Leu Ser Val His 
        355                 360                 365             


Asn Arg Ala Ile Arg Asn Cys Pro Trp Thr Val Ala Leu Trp Ser Arg 
    370                 375                 380                 


Tyr Leu Leu Ala Met Glu Arg His Gly Val Asp His Gln Val Ile Ser 
385                 390                 395                 400 


Val Thr Phe Glu Lys Ala Leu Asn Ala Gly Phe Ile Gln Ala Thr Asp 
                405                 410                 415     


Tyr Val Glu Ile Trp Gln Ala Tyr Leu Asp Tyr Leu Arg Arg Arg Val 
            420                 425                 430         


Asp Phe Lys Gln Asp Ser Ser Lys Glu Leu Glu Glu Leu Arg Ala Ala 
        435                 440                 445             


Phe Thr Arg Ala Leu Glu Tyr Leu Lys Gln Glu Val Glu Glu Arg Phe 
    450                 455                 460                 


Asn Glu Ser Gly Asp Pro Ser Cys Val Ile Met Gln Asn Trp Ala Arg 
465                 470                 475                 480 


Ile Glu Ala Arg Leu Cys Asn Asn Met Gln Lys Ala Arg Glu Leu Trp 
                485                 490                 495     


Asp Ser Ile Met Thr Arg Gly Asn Ala Lys Tyr Ala Asn Met Trp Leu 
            500                 505                 510         


Glu Tyr Tyr Asn Leu Glu Arg Ala His Gly Asp Thr Gln His Cys Arg 
        515                 520                 525             


Lys Ala Leu His Arg Ala Val Gln Cys Thr Ser Asp Tyr Pro Glu His 
    530                 535                 540                 


Val Cys Glu Val Leu Leu Thr Met Glu Arg Thr Glu Gly Ser Leu Glu 
545                 550                 555                 560 


Asp Trp Asp Ile Ala Val Gln Lys Thr Glu Thr Arg Leu Ala Arg Val 
                565                 570                 575     


Asn Glu Gln Arg Met Lys Ala Ala Glu Lys Glu Ala Ala Leu Val Gln 
            580                 585                 590         


Gln Glu Glu Glu Lys Ala Glu Gln Arg Lys Arg Ala Arg Ala Glu Lys 
        595                 600                 605             


Lys Ala Leu Lys Lys Lys Lys Lys Ile Arg Gly Pro Glu Lys Arg Gly 
    610                 615                 620                 


Ala Asp Glu Asp Asp Glu Lys Glu Trp Gly Asp Asp Glu Glu Glu Gln 
625                 630                 635                 640 


Pro Ser Lys Arg Arg Arg Val Glu Asn Ser Ile Pro Ala Ala Gly Glu 
                645                 650                 655     


Thr Gln Asn Val Glu Val Ala Ala Gly Pro Ala Gly Lys Cys Ala Ala 
            660                 665                 670         


Val Asp Val Glu Pro Pro Ser Lys Gln Lys Glu Lys Ala Ala Ser Leu 
        675                 680                 685             


Lys Arg Asp Met Pro Lys Val Leu His Asp Ser Ser Lys Asp Ser Ile 
    690                 695                 700                 


Thr Val Phe Val Ser Asn Leu Pro Tyr Ser Met Gln Glu Pro Asp Thr 
705                 710                 715                 720 


Lys Leu Arg Pro Leu Phe Glu Ala Cys Gly Glu Val Val Gln Ile Arg 
                725                 730                 735     


Pro Ile Phe Ser Asn Arg Gly Asp Phe Arg Gly Tyr Cys Tyr Val Glu 
            740                 745                 750         


Phe Lys Glu Glu Lys Ser Ala Leu Gln Ala Leu Glu Met Asp Arg Lys 
        755                 760                 765             


Ser Val Glu Gly Arg Pro Met Phe Val Ser Pro Cys Val Asp Lys Ser 
    770                 775                 780                 


Lys Asn Pro Asp Phe Lys Val Phe Arg Tyr Ser Thr Ser Leu Glu Lys 
785                 790                 795                 800 


His Lys Leu Phe Ile Ser Gly Leu Pro Phe Ser Cys Thr Lys Glu Glu 
                805                 810                 815     


Leu Glu Glu Ile Cys Lys Ala His Gly Thr Val Lys Asp Leu Arg Leu 
            820                 825                 830         


Val Thr Asn Arg Ala Gly Lys Pro Lys Gly Leu Ala Tyr Val Glu Tyr 
        835                 840                 845             


Glu Asn Glu Ser Gln Ala Ser Gln Ala Val Met Lys Met Asp Gly Met 
    850                 855                 860                 


Thr Ile Lys Glu Asn Ile Ile Lys Val Ala Ile Ser Asn Pro Pro Gln 
865                 870                 875                 880 


Arg Lys Val Pro Glu Lys Pro Glu Thr Arg Lys Ala Pro Gly Gly Pro 
                885                 890                 895     


Met Leu Leu Pro Gln Thr Tyr Gly Ala Arg Gly Lys Gly Arg Thr Gln 
            900                 905                 910         


Leu Ser Leu Leu Pro Arg Ala Leu Gln Arg Pro Ser Ala Ala Ala Pro 
        915                 920                 925             


Gln Ala Glu Asn Gly Pro Ala Ala Ala Pro Ala Val Ala Ala Pro Ala 
    930                 935                 940                 


Ala Thr Glu Ala Pro Lys Met Ser Asn Ala Asp Phe Ala Lys Leu Phe 
945                 950                 955                 960 


Leu Arg Lys 
            


<210>  3395
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SART-3__Homo_sapiens__AAH93784

<400>  3395
auggcgacug cggccgaaac cucggcuuca gaacccgagg cugaguccaa ggcugggccc       60

aaggcugacg gagaggagga ugagguuaag gcggcuagga caaggagaaa gguguuaucg      120

cgggcugugg ccgcugcgac auacaagacc auggggccag cgugggauca gcaggaggaa      180

ggcgugagcg agagcgaugg ggaugaguac gccauggcuu ccuccgcgga gagcuccccc      240

ggggaguacg agugggaaua ugacgaagag gaggagaaaa accagcugga gauugagaga      300

cuggaggagc aguugucuau caacgucuau gacuacaacu gccaugugga cuugaucaga      360

cugcucaggc uggaagggga gcuuaccaag gugaggaugg cccgccagaa gaugagugaa      420

aucuuucccu ugacugaaga gcucuggcug gaguggcugc augacgagau cagcauggcc      480

caggauggcc uggacagaga gcacguguau gaccucuuug agaaagccgu gaaggauuac      540

auuuguccua acauuuggcu agaguauggc caguacucag uuggugggau uggucagaaa      600

gguggccuug agaaaguucg cuccguguuu gaaagggcuc ucucgucugu ugguuuacau      660

augaccaaag gacucgcccu cugggaggcu uaccgagagu uugaaagugc gauuguggaa      720

gcugcucggc uugagaaagu ccacagucuu uuccggcgac aguuggcgau cccacucuau      780

gauauggagg ccacauuugc agaguaugaa gaauggucag aagacccaau accagaguca      840

guaauucaga acuauaacaa agcacuacag cagcuggaga aauauaaacc cuaugaagaa      900

gcacuguugc aggcagaggc accaaggcug gcagaauauc aagcauauau cgauuuugag      960

augaaaauug gcgauccugc ucgcauucag uugaucuuug agcgcgcccu ggucgagaac     1020

ugccuugucc cagacuuaug gauccguuac agucaguacc uagaucgaca acugaaagua     1080

aaggauuugg uuuuaucugu acauaaccgc gcuauuagaa acugccccug gacaguugcc     1140

uuauggaguc gguaccucuu ggccauggag agacauggag uugaucauca aguaauuucu     1200

guaaccuucg agaaagcuuu gaaugccggc uucauccagg ccacugauua uguggagauu     1260

uggcaggcau accuugauua ccugaggaga aggguugauu ucaaacaaga cuccaguaaa     1320

gagcuggagg aguugagggc cgccuuuacu cgugccuugg aguaucugaa gcaggaggug     1380

gaagagcguu ucaaugagag uggugaucca agcugcguga uuaugcagaa cugggcuagg     1440

auugaggcuc gacugugcaa uaacaugcag aaagcucggg aacucuggga uagcaucaug     1500

accagaggaa augccaagua cgccaacaug uggcuagagu auuacaaccu ggaaagagcu     1560

cauggugaca cccagcacug ccggaaggcu cugcaccggg ccguccagug caccagugac     1620

uacccagagc acgucugcga aguguuacuc accauggaga ggacagaagg uucuuuagaa     1680

gauugggaua uagcuguuca gaaaacugaa acccgauuag cucgugucaa ugagcagaga     1740

augaaggcug cagagaagga agcagcccuu gugcagcaag aagaagaaaa ggcugaacaa     1800

cggaaaagag cucgggcuga gaagaaagcg uuaaaaaaga agaaaaagau cagaggccca     1860

gagaagcgcg gagcagauga ggacgaugag aaagaguggg gcgaugauga agaagagcag     1920

ccuuccaaac gcagaagggu cgagaacagc aucccugcag cuggagaaac acaaaaugua     1980

gaaguagcag cagggcccgc ugggaaaugu gcugccguag auguggagcc cccuucgaag     2040

cagaaggaga aggcagccuc ccugaagagg gacaugccca aggugcugca cgacagcagc     2100

aaggacagca ucaccgucuu ugucagcaac cugcccuaca gcaugcagga gccggacacg     2160

aagcucaggc cacucuucga ggccuguggg gagguggucc agauccgacc caucuucagc     2220

aaccgugggg auuuccgagg uuacugcuac guggaguuua aagaagagaa aucagcccuu     2280

caggcacugg agauggaccg gaaaagugua gaagggaggc caauguuugu uucccccugu     2340

guggauaaga gcaaaaaccc cgauuuuaag guguucaggu acagcacuuc ccuagagaaa     2400

cacaagcugu ucaucucagg ccugccuuuc uccuguacua aagaggaacu agaagaaauc     2460

uguaaggcuc auggcaccgu gaaggaccuc aggcugguca ccaaccgggc uggcaaacca     2520

aagggccugg ccuacgugga guaugaaaau gaaucccagg cgucgcaggc ugugaugaag     2580

auggacggca ugacuaucaa agagaacauc aucaaagugg caaucagcaa cccuccucag     2640

aggaaaguuc cagagaagcc agagaccagg aaggcaccag guggccccau gcuuuugccg     2700

cagacauacg gagcgagggg gaagggaagg acgcagcugu cucuacugcc ucgugcccug     2760

cagcgcccaa gugcugcagc uccucaggcu gagaacggcc cugccgcggc uccugcaguu     2820

gccgccccag cagccaccga ggcacccaag auguccaaug ccgauuuugc caagcuguuu     2880

cugagaaagu ga                                                         2892


<210>  3396
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SART-3__Homo_sapiens__AAH93784

<400>  3396
auggccaccg ccgcggagac cagcgccucc gagcccgagg ccgagagcaa ggccggcccg       60

aaggccgacg gggaggagga cgaggugaag gcggcccgca cgcggcgcaa gguccugucc      120

cgggccgugg ccgcggccac cuacaagacc augggccccg ccugggacca gcaggaggag      180

ggggugagcg aguccgacgg cgacgaguac gccauggcca gcuccgcgga gagcuccccc      240

ggggaguacg agugggagua cgacgaggag gaggagaaga accagcucga gaucgagcgc      300

cuggaggagc agcugagcau caacgucuac gacuacaacu gccacgugga ccucauccgg      360

cugcugcgcc ucgagggcga gcugaccaag gugcggaugg cccgccagaa gauguccgag      420

aucuuccccc ugacggagga gcucuggcug gaguggcugc acgacgagau cagcauggcc      480

caggacggcc ucgaccggga gcacgucuac gaccuguucg agaaggccgu gaaggacuac      540

aucugcccga acaucuggcu ggaguacggg caguacuccg ugggcgggau cggccagaag      600

ggcgggcucg agaagguccg cagcguguuc gagcgggccc uguccagcgu gggccugcac      660

augaccaagg ggcucgcgcu gugggaggcc uaccgcgagu ucgaguccgc caucgucgag      720

gccgcccggc uggagaaggu gcacagccuc uuccgccggc agcuggcgau cccccuguac      780

gacauggagg ccaccuucgc cgaguacgag gagugguccg aggaccccau ccccgagagc      840

gugauccaga acuacaacaa ggcccuccag cagcuggaga aguacaagcc guacgaggag      900

gcccugcucc aggcggaggc gccccgccug gccgaguacc aggccuacau cgacuucgag      960

augaagaucg gcgaccccgc ccggauccag cugaucuucg agcgcgcccu cgucgagaac     1020

ugccuggugc ccgaccugug gauccgguac agccaguacc ucgaccgcca gcugaaggug     1080

aaggaccugg uccucuccgu gcacaaccgg gccauccgca acugcccgug gaccguggcc     1140

cuguggagcc gcuaccugcu cgccauggag cggcacgggg ucgaccacca ggugaucucc     1200

gugacguucg agaaggcgcu gaacgccggc uucauccagg ccaccgacua cgucgagauc     1260

uggcaggccu accuggacua ccuccgccgg cgcguggacu ucaagcagga cagcuccaag     1320

gagcuggagg agcugcgggc cgcguucacc cgcgcccucg aguaccugaa gcaggagguc     1380

gaggagcggu ucaacgagag cggcgacccc uccugcguga ucaugcagaa cugggcccgc     1440

aucgaggccc ggcugugcaa caacaugcag aaggcccgcg agcucuggga cagcaucaug     1500

acccggggga acgcgaagua cgccaacaug uggcuggagu acuacaaccu ggagcgcgcc     1560

cacggcgaca cgcagcacug ccggaaggcc cugcaccgcg cggugcagug caccuccgac     1620

uaccccgagc acgucugcga ggugcuccug accauggagc ggaccgaggg gagccuggag     1680

gacugggaca ucgccgugca gaagacggag acccgccucg cccgggucaa cgagcagcgc     1740

augaaggccg ccgagaagga ggcggcccug gugcagcagg aggaggagaa ggccgagcag     1800

cggaagcgcg cccgcgccga gaagaaggcg cugaagaaga agaagaagau ccggggcccc     1860

gagaagcgcg gggccgacga ggacgacgag aaggaguggg gcgacgacga ggaggagcag     1920

ccguccaagc ggcgccgggu ggagaacagc auccccgccg ccggcgagac ccagaacguc     1980

gagguggccg cggggcccgc cggcaagugc gccgccgugg acgucgagcc cccguccaag     2040

cagaaggaga aggcggccag ccucaagcgc gacaugccca aggugcugca cgacuccagc     2100

aaggacucca ucaccguguu cgucagcaac cugcccuacu ccaugcagga gcccgacacg     2160

aagcuccggc cgcuguucga ggccugcggg gagguggugc agauccgccc caucuucagc     2220

aaccggggcg acuuccgcgg guacugcuac gucgaguuca aggaggagaa guccgcccug     2280

caggcccucg agauggaccg caagagcgug gagggccggc ccauguucgu gagccccugc     2340

gucgacaagu ccaagaaccc ggacuucaag guguuccggu acagcaccuc ccuggagaag     2400

cacaagcugu ucaucagcgg ccuccccuuc uccugcacca aggaggagcu ggaggagauc     2460

ugcaaggcgc acgggaccgu gaaggaccug cgccucguca cgaaccgggc cggcaagccc     2520

aaggggcugg ccuacgugga guacgagaac gagagccagg ccucccaggc cgugaugaag     2580

auggacggca ugaccaucaa ggagaacauc aucaaggucg cgaucagcaa cccgccccag     2640

cgcaaggugc ccgagaagcc cgagacccgg aaggcccccg ggggcccgau gcugcucccc     2700

cagaccuacg gcgcccgcgg gaagggccgg acgcagcugu cccugcuccc ccgcgcccug     2760

cagcggccga gcgccgcggc gccccaggcc gagaacgggc ccgccgccgc ccccgccgug     2820

gccgccccgg cggccaccga ggcccccaag auguccaacg ccgacuucgc caagcuguuc     2880

cuccgcaagu ga                                                         2892


<210>  3397
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SART-3__Homo_sapiens__AAH93784

<400>  3397
auggccaccg ccgccgagac cuccgccucc gagcccgagg ccgaguccaa ggccggcccc       60

aaggccgacg gcgaggagga cgaggucaag gccgcccgca cccgccgcaa gguccucucc      120

cgcgccgucg ccgccgccac cuacaagacc augggccccg ccugggacca gcaggaggag      180

ggcgucuccg aguccgacgg cgacgaguac gccauggccu ccuccgccga guccuccccc      240

ggcgaguacg agugggagua cgacgaggag gaggagaaga accagcucga gaucgagcgc      300

cucgaggagc agcucuccau caacgucuac gacuacaacu gccacgucga ccucauccgc      360

cuccuccgcc ucgagggcga gcucaccaag guccgcaugg cccgccagaa gauguccgag      420

aucuuccccc ucaccgagga gcucuggcuc gaguggcucc acgacgagau cuccauggcc      480

caggacggcc ucgaccgcga gcacgucuac gaccucuucg agaaggccgu caaggacuac      540

aucugcccca acaucuggcu cgaguacggc caguacuccg ucggcggcau cggccagaag      600

ggcggccucg agaagguccg cuccgucuuc gagcgcgccc ucuccuccgu cggccuccac      660

augaccaagg gccucgcccu cugggaggcc uaccgcgagu ucgaguccgc caucgucgag      720

gccgcccgcc ucgagaaggu ccacucccuc uuccgccgcc agcucgccau cccccucuac      780

gacauggagg ccaccuucgc cgaguacgag gagugguccg aggaccccau ccccgagucc      840

gucauccaga acuacaacaa ggcccuccag cagcucgaga aguacaagcc cuacgaggag      900

gcccuccucc aggccgaggc cccccgccuc gccgaguacc aggccuacau cgacuucgag      960

augaagaucg gcgaccccgc ccgcauccag cucaucuucg agcgcgcccu cgucgagaac     1020

ugccucgucc ccgaccucug gauccgcuac ucccaguacc ucgaccgcca gcucaagguc     1080

aaggaccucg uccucuccgu ccacaaccgc gccauccgca acugccccug gaccgucgcc     1140

cucugguccc gcuaccuccu cgccauggag cgccacggcg ucgaccacca ggucaucucc     1200

gucaccuucg agaaggcccu caacgccggc uucauccagg ccaccgacua cgucgagauc     1260

uggcaggccu accucgacua ccuccgccgc cgcgucgacu ucaagcagga cuccuccaag     1320

gagcucgagg agcuccgcgc cgccuucacc cgcgcccucg aguaccucaa gcaggagguc     1380

gaggagcgcu ucaacgaguc cggcgacccc uccugcguca ucaugcagaa cugggcccgc     1440

aucgaggccc gccucugcaa caacaugcag aaggcccgcg agcucuggga cuccaucaug     1500

acccgcggca acgccaagua cgccaacaug uggcucgagu acuacaaccu cgagcgcgcc     1560

cacggcgaca cccagcacug ccgcaaggcc cuccaccgcg ccguccagug caccuccgac     1620

uaccccgagc acgucugcga gguccuccuc accauggagc gcaccgaggg cucccucgag     1680

gacugggaca ucgccgucca gaagaccgag acccgccucg cccgcgucaa cgagcagcgc     1740

augaaggccg ccgagaagga ggccgcccuc guccagcagg aggaggagaa ggccgagcag     1800

cgcaagcgcg cccgcgccga gaagaaggcc cucaagaaga agaagaagau ccgcggcccc     1860

gagaagcgcg gcgccgacga ggacgacgag aaggaguggg gcgacgacga ggaggagcag     1920

cccuccaagc gccgccgcgu cgagaacucc auccccgccg ccggcgagac ccagaacguc     1980

gaggucgccg ccggccccgc cggcaagugc gccgccgucg acgucgagcc ccccuccaag     2040

cagaaggaga aggccgccuc ccucaagcgc gacaugccca agguccucca cgacuccucc     2100

aaggacucca ucaccgucuu cgucuccaac cuccccuacu ccaugcagga gcccgacacc     2160

aagcuccgcc cccucuucga ggccugcggc gaggucgucc agauccgccc caucuucucc     2220

aaccgcggcg acuuccgcgg cuacugcuac gucgaguuca aggaggagaa guccgcccuc     2280

caggcccucg agauggaccg caaguccguc gagggccgcc ccauguucgu cucccccugc     2340

gucgacaagu ccaagaaccc cgacuucaag gucuuccgcu acuccaccuc ccucgagaag     2400

cacaagcucu ucaucuccgg ccuccccuuc uccugcacca aggaggagcu cgaggagauc     2460

ugcaaggccc acggcaccgu caaggaccuc cgccucguca ccaaccgcgc cggcaagccc     2520

aagggccucg ccuacgucga guacgagaac gagucccagg ccucccaggc cgucaugaag     2580

auggacggca ugaccaucaa ggagaacauc aucaaggucg ccaucuccaa ccccccccag     2640

cgcaaggucc ccgagaagcc cgagacccgc aaggcccccg gcggccccau gcuccucccc     2700

cagaccuacg gcgcccgcgg caagggccgc acccagcucu cccuccuccc ccgcgcccuc     2760

cagcgccccu ccgccgccgc cccccaggcc gagaacggcc ccgccgccgc ccccgccguc     2820

gccgcccccg ccgccaccga ggcccccaag auguccaacg ccgacuucgc caagcucuuc     2880

cuccgcaagu ga                                                         2892


<210>  3398
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SART-3__Homo_sapiens__AAH93784

<400>  3398
auggccaccg cugcagagac aagcgccucc gaacccgagg cggaaucuaa ggcuggcccu       60

aaagccgacg gggaggaaga ugaggugaag gcagccagaa cuaggcggaa aguccuguca      120

cgcgcuguug cagccgcuac guacaagacc augggaccag ccugggacca gcaagaggaa      180

ggugugagug agagcgaugg cgacgaauau gcgauggcau ccucugccga gucgucaccg      240

ggggaguacg aaugggagua ugaugaagag gaagagaaaa accagcucga gaucgaacga      300

cuugaggaac agcugagcau uaauguauac gacuauaacu gccacgugga uuugauacgu      360

uuacugagac uagagggaga acucacaaag gucaggaugg cucggcagaa gaugagugag      420

aucuuccccc ugacugagga acuuuggcug gagugguugc augacgaaau uuccauggcc      480

caagauggcc ucgaccgcga gcacguguac gaucuguuug aaaaagcagu uaaggacuau      540

aucuguccua auauuuggcu ggaguacggu caguacucug ucgggggaau cggccagaaa      600

ggcgggcucg agaaggugag aagcguguuc gaaagggcuu uauccucagu aggacugcau      660

augaccaaag gucuugccuu gugggaggcg uaucgggaau uugagagugc cauaguugag      720

gcagcucgcc uggaaaaggu gcacagccua uuccgaagac agcucgccau cccacuguac      780

gauauggagg cuacauuugc cgaauaugag gaauggucug aggaccccau uccugagucc      840

gucauccaaa acuacaauaa ggcacuucag cagcuggaaa aauauaagcc auacgaggaa      900

gccuugcucc aggcugaggc gcccaggcug gcagaauauc aagccuacau ugacuucgag      960

augaaaaucg gcgauccugc ucggauacag uuaauuuuug agcgugcccu gguggaaaac     1020

ugccucgugc cagaccuuug gauccgcuac ucacaguauc uggauagaca auugaagguc     1080

aaagaccuag uucugagcgu gcauaauagg gcaauucgga acuguccgug gaccguagcc     1140

cucuggaguc gauaccugcu ugcuauggag cgccacgggg uggaucacca ggucaucucu     1200

gugacuuucg aaaaggcccu gaaugcagga uuuauccagg cgacagacua uguugagauu     1260

uggcaggcuu acuuggauua ucucagaagg cggguggacu ucaaacaaga uuccagcaag     1320

gaacuggagg aguuacgcgc cgcauuuacc agagcccugg aauaccuaaa gcaggagguc     1380

gaagagaggu ucaacgaguc gggcgacccc ucuugcguga uaaugcagaa uugggcucgu     1440

aucgaagccc ggcucuguaa caauaugcag aaagcacgag agcuguggga uuccauuaug     1500

acgagaggua acgcuaagua ugccaauaug uggcuugaau acuacaacuu ggagagggcg     1560

cauggggaca cucaacacug ccgcaaagcc cugcaucggg cuguacagug uaccucagac     1620

uauccugaac acguuugcga ggugcuccug acaauggaga gaacugaagg aagucuugag     1680

gauugggaca ucgcagucca gaagaccgaa acaaggcugg cccgcgugaa cgagcagcga     1740

augaaagcug ccgaaaagga ggcagcguug guccaacagg aggaagagaa ggccgaacag     1800

cggaaacgug cuagagccga gaagaaagca cucaagaaaa agaagaaaau aaggggccca     1860

gaaaagcgcg gcgcugauga ggacgaugag aaagaauggg gagacgauga ggaagaacag     1920

cccagcaagc ggagaagggu ggaaaauucc auuccugccg caggggaaac ccaaaacguu     1980

gagguggccg cugguccagc gggcaaaugu gccgcaguag acgucgaacc cccgucuaag     2040

cagaaggaga aagcugccag ccugaagcga gauaugccua aaguguuaca cgacucaagu     2100

aaggauucca ucacgguuuu ugugagcaau cugcccuacu cuaugcagga accagacacu     2160

aaacuacgcc cucucuucga ggccugcggg gaggucgugc aaauccggcc cauuuucuca     2220

aacagaggag auuuuagggg cuauuguuac guagaguuca aggaggagaa aagugcucug     2280

caggcacuug agauggaccg uaagagcgug gaaggucgcc caauguuugu uucccccugc     2340

gucgacaagu cuaaaaaucc ugauuucaag guguuucggu auucgaccag cuuggagaaa     2400

cauaagcugu ucaucuccgg gcucccauuu ucaugcacaa aagaggaacu ggaggaaauu     2460

uguaaggccc acggcacugu gaaggacuua agacugguca caaacagggc gggaaaaccg     2520

aagggccuug cuuacguuga guaugaaaau gagagucagg ccucucaggc agugaugaaa     2580

auggauggga ugaccauaaa ggagaacauc auuaaagugg ccaucagcaa ucccccucaa     2640

cgaaagguac cagaaaagcc cgagacgcgg aaagcuccug gagguccaau guugcucccc     2700

cagaccuacg gcgcacgcgg gaagggaaga acacagcugu cccuacugcc gagggcccuc     2760

cagcggccuu cagcggcugc cccacaagca gaaaacggcc ccgccgcugc cccugcaguc     2820

gcugcccccg cggccacuga ggcaccaaaa augagcaaug cugacuucgc caagcuguuu     2880

cuucgaaaau ga                                                         2892


<210>  3399
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SART-3__Homo_sapiens__AAH93784

<400>  3399
auggccaccg ccgccgagac cagcgccagc gagcccgagg ccgagagcaa ggccggcccc       60

aaggccgacg gcgaggagga cgaggugaag gccgccagaa ccagaagaaa ggugcugagc      120

agagccgugg ccgccgccac cuacaagacc augggccccg ccugggacca gcaggaggag      180

ggcgugagcg agagcgacgg cgacgaguac gccauggcca gcagcgccga gagcagcccc      240

ggcgaguacg agugggagua cgacgaggag gaggagaaga accagcugga gaucgagaga      300

cuggaggagc agcugagcau caacguguac gacuacaacu gccacgugga ccugaucaga      360

cugcugagac uggagggcga gcugaccaag gugagaaugg ccagacagaa gaugagcgag      420

aucuuccccc ugaccgagga gcuguggcug gaguggcugc acgacgagau cagcauggcc      480

caggacggcc uggacagaga gcacguguac gaccuguucg agaaggccgu gaaggacuac      540

aucugcccca acaucuggcu ggaguacggc caguacagcg ugggcggcau cggccagaag      600

ggcggccugg agaaggugag aagcguguuc gagagagccc ugagcagcgu gggccugcac      660

augaccaagg gccuggcccu gugggaggcc uacagagagu ucgagagcgc caucguggag      720

gccgccagac uggagaaggu gcacagccug uucagaagac agcuggccau cccccuguac      780

gacauggagg ccaccuucgc cgaguacgag gaguggagcg aggaccccau ccccgagagc      840

gugauccaga acuacaacaa ggcccugcag cagcuggaga aguacaagcc cuacgaggag      900

gcccugcugc aggccgaggc ccccagacug gccgaguacc aggccuacau cgacuucgag      960

augaagaucg gcgaccccgc cagaauccag cugaucuucg agagagcccu gguggagaac     1020

ugccuggugc ccgaccugug gaucagauac agccaguacc uggacagaca gcugaaggug     1080

aaggaccugg ugcugagcgu gcacaacaga gccaucagaa acugccccug gaccguggcc     1140

cuguggagca gauaccugcu ggccauggag agacacggcg uggaccacca ggugaucagc     1200

gugaccuucg agaaggcccu gaacgccggc uucauccagg ccaccgacua cguggagauc     1260

uggcaggccu accuggacua ccugagaaga agaguggacu ucaagcagga cagcagcaag     1320

gagcuggagg agcugagagc cgccuucacc agagcccugg aguaccugaa gcaggaggug     1380

gaggagagau ucaacgagag cggcgacccc agcugcguga ucaugcagaa cugggccaga     1440

aucgaggcca gacugugcaa caacaugcag aaggccagag agcuguggga cagcaucaug     1500

accagaggca acgccaagua cgccaacaug uggcuggagu acuacaaccu ggagagagcc     1560

cacggcgaca cccagcacug cagaaaggcc cugcacagag ccgugcagug caccagcgac     1620

uaccccgagc acgugugcga ggugcugcug accauggaga gaaccgaggg cagccuggag     1680

gacugggaca ucgccgugca gaagaccgag accagacugg ccagagugaa cgagcagaga     1740

augaaggccg ccgagaagga ggccgcccug gugcagcagg aggaggagaa ggccgagcag     1800

agaaagagag ccagagccga gaagaaggcc cugaagaaga agaagaagau cagaggcccc     1860

gagaagagag gcgccgacga ggacgacgag aaggaguggg gcgacgacga ggaggagcag     1920

cccagcaaga gaagaagagu ggagaacagc auccccgccg ccggcgagac ccagaacgug     1980

gagguggccg ccggccccgc cggcaagugc gccgccgugg acguggagcc ccccagcaag     2040

cagaaggaga aggccgccag ccugaagaga gacaugccca aggugcugca cgacagcagc     2100

aaggacagca ucaccguguu cgugagcaac cugcccuaca gcaugcagga gcccgacacc     2160

aagcugagac cccuguucga ggccugcggc gagguggugc agaucagacc caucuucagc     2220

aacagaggcg acuucagagg cuacugcuac guggaguuca aggaggagaa gagcgcccug     2280

caggcccugg agauggacag aaagagcgug gagggcagac ccauguucgu gagccccugc     2340

guggacaaga gcaagaaccc cgacuucaag guguucagau acagcaccag ccuggagaag     2400

cacaagcugu ucaucagcgg ccugcccuuc agcugcacca aggaggagcu ggaggagauc     2460

ugcaaggccc acggcaccgu gaaggaccug agacugguga ccaacagagc cggcaagccc     2520

aagggccugg ccuacgugga guacgagaac gagagccagg ccagccaggc cgugaugaag     2580

auggacggca ugaccaucaa ggagaacauc aucaaggugg ccaucagcaa ccccccccag     2640

agaaaggugc ccgagaagcc cgagaccaga aaggcccccg gcggccccau gcugcugccc     2700

cagaccuacg gcgccagagg caagggcaga acccagcuga gccugcugcc cagagcccug     2760

cagagaccca gcgccgccgc cccccaggcc gagaacggcc ccgccgccgc ccccgccgug     2820

gccgcccccg ccgccaccga ggcccccaag augagcaacg ccgacuucgc caagcuguuc     2880

cugagaaagu ga                                                         2892


<210>  3400
<211>  2892
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SART-3__Homo_sapiens__AAH93784

<400>  3400
auggccaccg cugccgagac aagcgcgucc gaacccgagg cugaaucuaa ggccggcccu       60

aaagccgacg gggaggaaga ugaggugaag gcugccagaa cgcggcgcaa aguccugagc      120

agagcuguug ccgcggccac cuacaagaca augggaccgg cuugggacca gcaagaggaa      180

ggcguguccg agucugaugg ggacgaauau gccauggcua gcuccgccga gucuagcccc      240

ggagaguacg aaugggagua ugaugaagag gaagagaaaa accagcucga gaucgaacgg      300

cuggaggaac agcuuuccau uaauguguac gacuauaacu gccacgucga ucugauccgc      360

cuccugagac uugagggcga acugaccaag gugcggaugg cgcgccagaa gaugagcgag      420

auuuucccuc ucacagagga acuguggcug gaguggcucc augacgaaau cucuauggcc      480

caagaugggc uggacagaga gcacguuuac gaucuuuuug aaaaagcugu gaaggacuau      540

auuuguccca auaucuggcu ggaguacgga caguacuccg ucggcggcau cgggcagaaa      600

ggaggccucg agaaggugcg gagcguuuuc gaacgcgccc ugucuuccgu ggggcuucau      660

augaccaaag gacuggcucu cugggaggcc uauagagaau uugagagcgc cauugucgag      720

gcugcgcggc uggaaaaggu gcacucucug uuccgcagac agcucgccau cccucuguac      780

gauauggagg cuacauuugc cgaauaugag gaaugguccg aggaccccau uccugagagc      840

gugauccaaa acuacaauaa ggcccuucag cagcuggaaa aauauaagcc guacgaggaa      900

gcucuccugc aggccgaggc gccccggcuu gcugaauauc aagccuacau ugacuucgag      960

augaaaaucg gcgauccugc ccgcauucag cugaucuuug agagagcucu cgucgaaaac     1020

ugccugguuc ccgaccugug gauccgguac ucccaguauc ucgauagaca acugaaggug     1080

aaagaccuug ugcugucugu ccauaaucgc gccauucgga acuguccuug gaccguggcu     1140

cucuggagca gauaccugcu ugccauggag cgccacgggg uugaucacca ggugaucucc     1200

gucacguucg aaaaggcgcu gaaugccgga uuuauucagg cuaccgacua uguggagauc     1260

uggcaggccu accucgauua ucugcggaga cgcguugacu ucaaacaaga uagcucuaag     1320

gaacuggagg agcuccgggc ugccuuuaca agagcgcugg aauaccuuaa gcaggaggug     1380

gaagaacgcu ucaacgaguc cggcgacccc agcugcguca uuaugcagaa uugggcccgg     1440

aucgaagcua gacuguguaa caauaugcag aaagcccgcg agcucuggga uucuaucaug     1500

acccggggca acgcuaagua ugccaauaug uggcuggaau acuacaaccu ggagagagcc     1560

cauggggaca cacaacacug ccggaaagcc cuucaucgcg cggugcagug uaccagcgac     1620

uauccggaac acgucugcga ggugcuccug acgauggaga gaacagaagg aucccuggag     1680

gauugggaca uugccguuca gaagaccgaa acacggcucg cuagagugaa cgagcagcgc     1740

augaaagccg ccgaaaagga ggcugcccug guccaacagg aggaagagaa ggcggaacag     1800

cggaaaagag cucgcgccga gaagaaagcc cuuaagaaaa agaagaaaau cagaggcccu     1860

gaaaagcgcg gggcugauga ggacgaugag aaagaauggg gagacgauga ggaggagcag     1920

cccucuaagc ggagacgggu ggagaauagc auuccugccg cgggcgaaac ccaaaacguu     1980

gagguggcug ccgggcccgc cggaaaaugu gcugccgucg acguggaacc cccuuccaag     2040

cagaaggaga aagcugccag ccugaagcgc gauaugccga aagugcucca cgacucuucc     2100

aaggauagca ucaccguuuu ugucucuaau cugcccuacu ccaugcagga accugacaca     2160

aaacugagac cccuuuucga ggcgugcggc gagguggugc aaauucggcc uaucuucagc     2220

aaccgcggcg auuuuagagg guauuguuac gucgaguuca aggaagaaaa auccgcccuc     2280

caggcucugg agauggaccg gaagucugug gaaggacgcc ccauguuugu uagcccgugc     2340

guggacaagu ccaaaaaucc ugauuucaag gucuuuagau auucuacgag ccuggagaaa     2400

cauaaacucu ucaucuccgg ccugcccuuu agcugcacca aggaggaacu ugaggaaauu     2460

uguaaggccc acgggacagu gaaggaccug cggcucguua ccaacagagc uggaaaaccu     2520

aagggccugg ccuacgugga guaugaaaau gagucucagg ccucccaggc ugucaugaaa     2580

auggauggga ugacaaucaa ggagaacauu aucaaagugg cgauuagcaa ucccccucaa     2640

cgcaagguuc ccgaaaagcc ggagacccgg aaagccccug gcggacccau gcugcuuccc     2700

cagacguacg gcgcuagagg gaagggacgc acacagcucu cucugcugcc ucgggcccuc     2760

cagagaccgu ccgccgcugc uccccaagcg gaaaacggcc cugcugccgc ccccgcugug     2820

gccgcgccug cugccaccga ggcccccaaa augagcaaug cugacuucgc caagcuguuu     2880

cuucgcaaau ga                                                         2892


<210>  3401
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SEPR__Homo_sapiens__Q12884

<400>  3401

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  3402
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SEPR__Homo_sapiens__AAC51668

<400>  3402
augaagacuu ggguaaaaau cguauuugga guugccaccu cugcugugcu ugccuuauug       60

gugaugugca uugucuuacg cccuucaaga guucauaacu cugaagaaaa uacaaugaga      120

gcacucacac ugaaggauau uuuaaaugga acauuuucuu auaaaacauu uuuuccaaac      180

uggauuucag gacaagaaua ucuucaucaa ucugcagaua acaauauagu acuuuauaau      240

auugaaacag ggcaaucaua uaccauuuug aguaauagaa ccaugaaaag ugugaaugcu      300

ucaaauuacg gcuuaucacc ugaucggcaa uuuguauauc uagaaaguga uuauucaaag      360

cuuuggagau acucuuacac agcaacauau uacaucuaug accuuagcaa uggagaauuu      420

guaagaggaa augagcuucc ucguccaauu caguauuuau gcuggucgcc uguugggagu      480

aaauuagcau augucuauca aaacaauauc uauuugaaac aaagaccagg agauccaccu      540

uuucaaauaa cauuuaaugg aagagaaaau aaaauauuua auggaauccc agacuggguu      600

uaugaagagg aaaugcuugc uacaaaauau gcucucuggu ggucuccuaa uggaaaauuu      660

uuggcauaug cggaauuuaa ugauacggau auaccaguua uugccuauuc cuauuauggc      720

gaugaacaau auccuagaac aauaaauauu ccauacccaa aggcuggagc uaagaauccc      780

guuguucgga uauuuauuau cgauaccacu uacccugcgu auguaggucc ccaggaagug      840

ccuguuccag caaugauagc cucaagugau uauuauuuca guuggcucac guggguuacu      900

gaugaacgag uauguuugca guggcuaaaa agaguccaga auguuucggu ccugucuaua      960

ugugacuuca gggaagacug gcagacaugg gauuguccaa agacccagga gcauauagaa     1020

gaaagcagaa cuggaugggc ugguggauuc uuuguuucaa caccaguuuu cagcuaugau     1080

gccauuucgu acuacaaaau auuuagugac aaggauggcu acaaacauau ucacuauauc     1140

aaagacacug uggaaaaugc uauucaaauu acaaguggca agugggaggc cauaaauaua     1200

uucagaguaa cacaggauuc acuguuuuau ucuagcaaug aauuugaaga auacccugga     1260

agaagaaaca ucuacagaau uagcauugga agcuauccuc caagcaagaa guguguuacu     1320

ugccaucuaa ggaaagaaag gugccaauau uacacagcaa guuucagcga cuacgccaag     1380

uacuaugcac uugucugcua cggcccaggc auccccauuu ccacccuuca ugauggacgc     1440

acugaucaag aaauuaaaau ccuggaagaa aacaaggaau uggaaaaugc uuugaaaaau     1500

auccagcugc cuaaagagga aauuaagaaa cuugaaguag augaaauuac uuuaugguac     1560

aagaugauuc uuccuccuca auuugacaga ucaaagaagu aucccuugcu aauucaagug     1620

uauggugguc ccugcaguca gaguguaagg ucuguauuug cuguuaauug gauaucuuau     1680

cuugcaagua aggaagggau ggucauugcc uugguggaug gucgaggaac agcuuuccaa     1740

ggugacaaac uccucuaugc aguguaucga aagcugggug uuuaugaagu ugaagaccag     1800

auuacagcug ucagaaaauu cauagaaaug gguuucauug augaaaaaag aauagccaua     1860

uggggcuggu ccuauggagg auacguuuca ucacuggccc uugcaucugg aacuggucuu     1920

uucaaaugug guauagcagu ggcuccaguc uccagcuggg aauauuacgc gucugucuac     1980

acagagagau ucaugggucu cccaacaaag gaugauaauc uugagcacua uaagaauuca     2040

acugugaugg caagagcaga auauuucaga aauguagacu aucuucucau ccacggaaca     2100

gcagaugaua augugcacuu ucagaacuca gcacagauug cuaaagcucu gguuaaugca     2160

caaguggauu uccaggcaau gugguacucu gaccagaacc acggcuuauc cggccugucc     2220

acgaaccacu uauacaccca caugacccac uuccuaaagc aguguuucuc uuugucagac     2280

uaa                                                                   2283


<210>  3403
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SEPR__Homo_sapiens__AAC51668

<400>  3403
augaagaccu gggugaagau cgucuucggc guggccacca gcgccgugcu ggcgcuccug       60

gucaugugca ucgugcugcg ccccucccgg gugcacaaca gcgaggagaa cacgaugcgc      120

gcccucaccc ugaaggacau ccugaacggg accuucuccu acaagaccuu cuucccgaac      180

uggaucagcg gccaggagua ccuccaccag uccgccgaca acaacaucgu ccuguacaac      240

aucgagacgg ggcagagcua caccauccug uccaaccgga ccaugaaguc cgugaacgcc      300

agcaacuacg gccucagccc cgaccgccag uucguguacc uggaguccga cuacagcaag      360

cuguggcggu acuccuacac cgccacguac uacaucuacg accucagcaa cggggaguuc      420

guccgcggca acgagcugcc ccggcccauc caguaccugu gcuggucccc ggugggcagc      480

aagcucgcgu acguguacca gaacaacauc uaccugaagc agcgccccgg ggacccgccc      540

uuccagauca ccuucaacgg ccgggagaac aagaucuuca acgggauccc cgacuggguc      600

uacgaggagg agaugcuggc caccaaguac gcccucuggu ggucccccaa cggcaaguuc      660

cuggccuacg cggaguucaa cgacaccgac auccccguga ucgccuacag cuacuacggg      720

gacgagcagu acccccgcac gaucaacauc ccguacccca aggccggcgc caagaacccc      780

gugguccgga ucuucaucau cgacaccacc uaccccgccu acgugggccc gcaggaggug      840

cccguccccg cgaugaucgc cuccagcgac uacuacuuca gcuggcugac cugggugacg      900

gacgagcgcg ugugccucca guggcugaag cggguccaga acguguccgu gcugagcauc      960

ugcgacuucc gcgaggacug gcagaccugg gacugcccca agacccagga gcacaucgag     1020

gagucccgga ccgggugggc cggcggguuc uucgucagca cgccgguguu cuccuacgac     1080

gccaucagcu acuacaagau cuucuccgac aaggacggcu acaagcacau ccacuacauc     1140

aaggacaccg ucgagaacgc cauccagauc accagcggca agugggaggc gaucaacauc     1200

uuccgcguga cccaggacuc ccucuucuac agcuccaacg aguucgagga guaccccggg     1260

cggcgcaaca ucuaccggau cagcaucggc uccuacccgc ccagcaagaa gugcgugacg     1320

ugccaccucc gcaaggagcg gugccaguac uacaccgccu ccuucagcga cuacgccaag     1380

uacuacgccc uggucugcua cgggcccggc auccccaucu ccacccugca cgacgggcgc     1440

accgaccagg agaucaagau ccuggaggag aacaaggagc uggagaacgc ccucaagaac     1500

auccagcugc ccaaggagga gaucaagaag cuggaggugg acgagaucac gcucugguac     1560

aagaugaucc ugcccccgca guucgaccgc agcaagaagu acccccugcu cauccaggug     1620

uacggcggcc ccugcuccca gagcguccgg agcguguucg cggugaacug gaucuccuac     1680

cuggccagca aggaggggau ggucaucgcc cugguggacg gccgcgggac cgccuuccag     1740

ggcgacaagc uccuguacgc cguguaccgg aagcuggggg ucuacgaggu ggaggaccag     1800

aucaccgcgg ugcgcaaguu caucgagaug ggcuucaucg acgagaagcg gaucgccauc     1860

uggggcuggu ccuacggggg cuacgucagc ucccucgccc uggccagcgg gaccggccug     1920

uucaagugcg ggaucgcggu ggccccggug uccagcuggg aguacuacgc cuccgucuac     1980

acggagcgcu ucaugggccu ccccaccaag gacgacaacc uggagcacua caagaacagc     2040

accgugaugg cccgggccga guacuuccgc aacguggacu accugcucau ccacggcacc     2100

gcggacgaca acguccacuu ccagaacucc gcccagaucg ccaaggcccu ggugaacgcc     2160

cagguggacu uccaggcgau gugguacagc gaccagaacc acgggcuguc cggccugagc     2220

acgaaccacc ucuacaccca caugacccac uuccugaagc agugcuucuc ccugagcgac     2280

uga                                                                   2283


<210>  3404
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SEPR__Homo_sapiens__AAC51668

<400>  3404
augaagaccu gggucaagau cgucuucggc gucgccaccu ccgccguccu cgcccuccuc       60

gucaugugca ucguccuccg ccccucccgc guccacaacu ccgaggagaa caccaugcgc      120

gcccucaccc ucaaggacau ccucaacggc accuucuccu acaagaccuu cuuccccaac      180

uggaucuccg gccaggagua ccuccaccag uccgccgaca acaacaucgu ccucuacaac      240

aucgagaccg gccaguccua caccauccuc uccaaccgca ccaugaaguc cgucaacgcc      300

uccaacuacg gccucucccc cgaccgccag uucgucuacc ucgaguccga cuacuccaag      360

cucuggcgcu acuccuacac cgccaccuac uacaucuacg accucuccaa cggcgaguuc      420

guccgcggca acgagcuccc ccgccccauc caguaccucu gcuggucccc cgucggcucc      480

aagcucgccu acgucuacca gaacaacauc uaccucaagc agcgccccgg cgaccccccc      540

uuccagauca ccuucaacgg ccgcgagaac aagaucuuca acggcauccc cgacuggguc      600

uacgaggagg agaugcucgc caccaaguac gcccucuggu ggucccccaa cggcaaguuc      660

cucgccuacg ccgaguucaa cgacaccgac auccccguca ucgccuacuc cuacuacggc      720

gacgagcagu acccccgcac caucaacauc cccuacccca aggccggcgc caagaacccc      780

gucguccgca ucuucaucau cgacaccacc uaccccgccu acgucggccc ccaggagguc      840

cccguccccg ccaugaucgc cuccuccgac uacuacuucu ccuggcucac cugggucacc      900

gacgagcgcg ucugccucca guggcucaag cgcguccaga acgucuccgu ccucuccauc      960

ugcgacuucc gcgaggacug gcagaccugg gacugcccca agacccagga gcacaucgag     1020

gagucccgca ccggcugggc cggcggcuuc uucgucucca cccccgucuu cuccuacgac     1080

gccaucuccu acuacaagau cuucuccgac aaggacggcu acaagcacau ccacuacauc     1140

aaggacaccg ucgagaacgc cauccagauc accuccggca agugggaggc caucaacauc     1200

uuccgcguca cccaggacuc ccucuucuac uccuccaacg aguucgagga guaccccggc     1260

cgccgcaaca ucuaccgcau cuccaucggc uccuaccccc ccuccaagaa gugcgucacc     1320

ugccaccucc gcaaggagcg cugccaguac uacaccgccu ccuucuccga cuacgccaag     1380

uacuacgccc ucgucugcua cggccccggc auccccaucu ccacccucca cgacggccgc     1440

accgaccagg agaucaagau ccucgaggag aacaaggagc ucgagaacgc ccucaagaac     1500

auccagcucc ccaaggagga gaucaagaag cucgaggucg acgagaucac ccucugguac     1560

aagaugaucc ucccccccca guucgaccgc uccaagaagu acccccuccu cauccagguc     1620

uacggcggcc ccugcuccca guccguccgc uccgucuucg ccgucaacug gaucuccuac     1680

cucgccucca aggagggcau ggucaucgcc cucgucgacg gccgcggcac cgccuuccag     1740

ggcgacaagc uccucuacgc cgucuaccgc aagcucggcg ucuacgaggu cgaggaccag     1800

aucaccgccg uccgcaaguu caucgagaug ggcuucaucg acgagaagcg caucgccauc     1860

uggggcuggu ccuacggcgg cuacgucucc ucccucgccc ucgccuccgg caccggccuc     1920

uucaagugcg gcaucgccgu cgcccccguc uccuccuggg aguacuacgc cuccgucuac     1980

accgagcgcu ucaugggccu ccccaccaag gacgacaacc ucgagcacua caagaacucc     2040

accgucaugg cccgcgccga guacuuccgc aacgucgacu accuccucau ccacggcacc     2100

gccgacgaca acguccacuu ccagaacucc gcccagaucg ccaaggcccu cgucaacgcc     2160

caggucgacu uccaggccau gugguacucc gaccagaacc acggccucuc cggccucucc     2220

accaaccacc ucuacaccca caugacccac uuccucaagc agugcuucuc ccucuccgac     2280

uga                                                                   2283


<210>  3405
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SEPR__Homo_sapiens__AAC51668

<400>  3405
augaagaccu gggugaaaau cgucuucggc guugccacaa gcgcugugcu ggcacuccuu       60

guaaugugca uugugcugag acccuccagg guccacaacu cugaggaaaa uacuaugcgg      120

gccuugacgu uaaaggacau acugaacggg accuuuucau acaaaacauu cuuuccuaau      180

uggaucagug gacaggagua ucuacaucaa agcgcggaua acaauauugu gcucuacaac      240

aucgaaacug gucaguccua uaccauucug ucuaaucgca caaugaaguc gguuaacgcu      300

ucaaauuacg gccuuagccc agaccgacag uucguguauc uggagaguga uuacuccaaa      360

uuguggcguu auucuuacac cgccacuuac uauaucuacg accucagcaa cggggaauuu      420

gucagaggaa augagcugcc gaggcccaua caguaucugu guuggucccc ugugggcuca      480

aagcucgcau acguauauca aaacaauauc uacuuaaagc agcggccagg ugaucccccu      540

uuccagauua cauuuaacgg gcgcgagaau aaaaucuuca acggcauucc agacuggguu      600

uaugaagagg aaaugcuggc caccaaguac gcucuuuggu ggagucccaa cggaaaauuu      660

uuggcauacg ccgaguucaa ugauacggac aucccuguga uagcuuauag cuacuauggc      720

gaugagcagu acccaagaac uauuaacauc ccguauccca aggccggggc gaaaaauccu      780

gucgugagga uuuuuaucau cgacaccaca uacccagcau augugggacc ccaagaaguc      840

ccuguuccag ccaugauugc uucuuccgau uacuacuucu cauggcugac uugggugacc      900

gacgagcggg uaugccuaca guggcucaag cgcgugcaga acgucagcgu gcugaguaua      960

ugugauuuuc gagaagacug gcagacaugg gacugcccca agacccaaga gcacaucgaa     1020

gagucuagaa cggguugggc cggcggguuc uucguuucca cuccgguguu uagcuaugau     1080

gcaauuucgu acuauaaaau cuucucugac aaggauggau acaaacauau acacuauauu     1140

aaggacacag ucgagaaugc uauccagauc accuccggca aaugggaagc cauuaacauc     1200

uuuaggguga cucaggauuc acuuuucuac aguagcaaug aguuugaaga guauccuggu     1260

cggcguaaca uuuaccgcau auccaucggg ucuuaucccc caagcaagaa auguguaaca     1320

ugccaucuga gaaaggaaag gugucaauac uacaccgcgu cauucaguga cuaugccaag     1380

uacuaugcau ugguuugcua cggaccuggc auucccaucu ccacgcucca cgauggccgg     1440

accgaccagg agaucaaaau ucuggaggaa aauaaggagu uagaaaacgc ucugaaaaau     1500

auacagcucc caaaggagga aaucaaaaag cuggaggugg augagauuac acuuugguau     1560

aagaugaucu ugcccccuca guuugaccga agcaaaaagu acccacuacu gauucaaguc     1620

uacgggggac cguguucuca gucagugcgc agugucuucg ccgugaacug gaucagcuau     1680

cucgcuucca aagaagguau gguuauagcc cugguggaug gcagagggac ugcauuucag     1740

ggagacaaac uucuguacgc cguauauagg aaguugggcg ucuacgaggu ggaagaccag     1800

aucaccgcug uucggaaguu cauugagaug gguuuuaucg augagaagcg cauugcgauc     1860

uggggguggu cuuauggcgg auacgugucg agccucgcac uggccuccgg cacaggguua     1920

uucaaaugcg gaauagcugu cgcccccgug ucaaguuggg aauauuacgc aucuguauac     1980

acugagagau uuaugggucu gccuaccaag gacgauaauc uagaacacua uaaaaacagc     2040

acagugaugg ccagggcuga guacuuccgu aauguugacu aucuccugau ucauggcacc     2100

gccgaugaca acguccacuu ccaaaacucc gcacagaucg cgaaggcucu ugugaaugcc     2160

cagguggauu uucaggcaau gugguacuca gaccaaaacc auggguugag cggacugucu     2220

acuaaucacc ucuauacgca caugacacau uuccugaaac aguguuuuuc ccuuagugau     2280

uga                                                                   2283


<210>  3406
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SEPR__Homo_sapiens__AAC51668

<400>  3406
augaagaccu gggugaagau cguguucggc guggccacca gcgccgugcu ggcccugcug       60

gugaugugca ucgugcugag acccagcaga gugcacaaca gcgaggagaa caccaugaga      120

gcccugaccc ugaaggacau ccugaacggc accuucagcu acaagaccuu cuuccccaac      180

uggaucagcg gccaggagua ccugcaccag agcgccgaca acaacaucgu gcuguacaac      240

aucgagaccg gccagagcua caccauccug agcaacagaa ccaugaagag cgugaacgcc      300

agcaacuacg gccugagccc cgacagacag uucguguacc uggagagcga cuacagcaag      360

cuguggagau acagcuacac cgccaccuac uacaucuacg accugagcaa cggcgaguuc      420

gugagaggca acgagcugcc cagacccauc caguaccugu gcuggagccc cgugggcagc      480

aagcuggccu acguguacca gaacaacauc uaccugaagc agagacccgg cgaccccccc      540

uuccagauca ccuucaacgg cagagagaac aagaucuuca acggcauccc cgacugggug      600

uacgaggagg agaugcuggc caccaaguac gcccuguggu ggagccccaa cggcaaguuc      660

cuggccuacg ccgaguucaa cgacaccgac auccccguga ucgccuacag cuacuacggc      720

gacgagcagu accccagaac caucaacauc cccuacccca aggccggcgc caagaacccc      780

guggugagaa ucuucaucau cgacaccacc uaccccgccu acgugggccc ccaggaggug      840

cccgugcccg ccaugaucgc cagcagcgac uacuacuuca gcuggcugac cugggugacc      900

gacgagagag ugugccugca guggcugaag agagugcaga acgugagcgu gcugagcauc      960

ugcgacuuca gagaggacug gcagaccugg gacugcccca agacccagga gcacaucgag     1020

gagagcagaa ccggcugggc cggcggcuuc uucgugagca cccccguguu cagcuacgac     1080

gccaucagcu acuacaagau cuucagcgac aaggacggcu acaagcacau ccacuacauc     1140

aaggacaccg uggagaacgc cauccagauc accagcggca agugggaggc caucaacauc     1200

uucagaguga cccaggacag ccuguucuac agcagcaacg aguucgagga guaccccggc     1260

agaagaaaca ucuacagaau cagcaucggc agcuaccccc ccagcaagaa gugcgugacc     1320

ugccaccuga gaaaggagag augccaguac uacaccgcca gcuucagcga cuacgccaag     1380

uacuacgccc uggugugcua cggccccggc auccccauca gcacccugca cgacggcaga     1440

accgaccagg agaucaagau ccuggaggag aacaaggagc uggagaacgc ccugaagaac     1500

auccagcugc ccaaggagga gaucaagaag cuggaggugg acgagaucac ccugugguac     1560

aagaugaucc ugccccccca guucgacaga agcaagaagu acccccugcu gauccaggug     1620

uacggcggcc ccugcagcca gagcgugaga agcguguucg ccgugaacug gaucagcuac     1680

cuggccagca aggagggcau ggugaucgcc cugguggacg gcagaggcac cgccuuccag     1740

ggcgacaagc ugcuguacgc cguguacaga aagcugggcg uguacgaggu ggaggaccag     1800

aucaccgccg ugagaaaguu caucgagaug ggcuucaucg acgagaagag aaucgccauc     1860

uggggcugga gcuacggcgg cuacgugagc agccuggccc uggccagcgg caccggccug     1920

uucaagugcg gcaucgccgu ggcccccgug agcagcuggg aguacuacgc cagcguguac     1980

accgagagau ucaugggccu gcccaccaag gacgacaacc uggagcacua caagaacagc     2040

accgugaugg ccagagccga guacuucaga aacguggacu accugcugau ccacggcacc     2100

gccgacgaca acgugcacuu ccagaacagc gcccagaucg ccaaggcccu ggugaacgcc     2160

cagguggacu uccaggccau gugguacagc gaccagaacc acggccugag cggccugagc     2220

accaaccacc uguacaccca caugacccac uuccugaagc agugcuucag ccugagcgac     2280

uga                                                                   2283


<210>  3407
<211>  2283
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SEPR__Homo_sapiens__AAC51668

<400>  3407
augaagaccu gggugaaaau cgucuucggc guugccacaa gcgcugugcu ggcccuccug       60

gugaugugca uuguccuuag acccucccgg gugcacaacu cugaggaaaa uacgaugcgc      120

gcgcugaccc ucaaggacau ccugaacggg acauuuagcu acaaaaccuu cuuuccuaau      180

uggauuuccg gacaggagua ucuucaucaa ucugcugaua acaauaucgu ucuguacaac      240

auugaaacag gccagagcua uaccauccuc uccaauagaa caaugaaguc ugugaacgcc      300

agcaauuacg ggcugucccc ggaccggcag uucgucuauc uggagagcga uuacucuaaa      360

cucuggcgcu auuccuacac cgccacguac uauaucuacg accugagcaa cggagaauuu      420

gugagaggca augagcuucc ccggccuauu caguaucugu guuggucucc cguugggucc      480

aagcucgcuu acguguauca aaacaauauc uaccugaagc agcgcccugg agaucccccu      540

uuccagauua ccuuuaacgg cagagagaau aaaaucuuca acggcauucc ggacuggguc      600

uaugaagagg aaaugcuugc cacaaaguac gcucuguggu ggagccccaa cgggaaauuu      660

cucgccuacg cggaguucaa ugauaccgac aucccuguga uugccuauuc uuacuaugga      720

gaugagcagu acccccggac aaucaacauc ccuuauccca aggcuggcgc caaaaauccg      780

gugguccgca uuuuuaucau ugacaccacg uacccugcuu auguugggcc ccaagaagug      840

ccugugcccg ccaugaucgc guccagcgau uacuacuucu ccuggcugac augggucacc      900

gacgagagag ugugccugca guggcucaag cggguucaga acgugucugu ccugagcauu      960

ugugauuuuc gcgaagacug gcagacaugg gacugcccca agacccaaga gcacaucgaa     1020

gaguccagaa ccggaugggc cggcggguuc uucgugagca caccuguguu uucuuaugau     1080

gcuaucuccu acuauaaaau uuucagcgac aaggauggau acaaacauau ccacuauauu     1140

aaggacacgg uugagaaugc cauccagauu accucuggca aaugggaagc uaucaacauc     1200

uuucggguca cacaggauag ccuuuucuac uccucuaaug aguuugaaga guauccgggc     1260

cgcagaaaca uuuaccggau cagcauuggg uccuaucccc cuagcaagaa augugugacc     1320

ugccaucuga gaaaggaacg cugucaauac uacacagccu cuuucuccga cuaugccaag     1380

uacuaugcuc ucgucugcua cggacccggc aucccuauua gcacccugca cgaugggcgg     1440

acggaccagg agaucaaaau ucuugaggaa aauaaggagc uggaaaacgc gcucaaaaau     1500

auccagcugc ccaaggagga aaucaaaaag cuggaggugg augagauuac acucugguau     1560

aagaugaucc ugccgccuca guuugacaga ucuaaaaagu acccccuucu gauucaaguu     1620

uacggaggcc cuuguuccca gagcgugcgc uccgucuucg ccgugaacug gaucucuuau     1680

cucgcuagca aagaagggau gguuauugcc cugguggaug gacggggcac cgccuuucag     1740

ggcgacaagc uccuguacgc ugucuauaga aaacucgggg uguacgaggu ggaagaccag     1800

aucaccgccg uucgcaaguu caucgagaug ggauuuauug augagaagcg gaucgcgauu     1860

uggggcuggu ccuauggggg auacgucucu agccuggcuc uggccuccgg cacagggcuu     1920

uucaaaugcg gcaucgccgu ggcucccgug agcucuuggg aauauuacgc cuccgucuac     1980

accgagagau uuaugggacu gccuacaaag gacgauaauc uugaacacua uaaaaacagc     2040

acggugaugg cucgcgccga guacuuccgg aauguugacu aucugcucau ucauggcacc     2100

gcggaugaca acgugcacuu ccaaaacucu gcccagaucg cuaaggcccu ggucaaugcu     2160

cagguggauu uucaggccau gugguacucc gaccaaaacc augggcugag cggacuuucu     2220

acaaaucacc ucuauaccca caugacacau uuccugaaac aguguuuuag ccuguccgau     2280

uga                                                                   2283


<210>  3408
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SIA7F__Homo_sapiens__Q969X2

<400>  3408

Met Ala Cys Ser Arg Pro Pro Ser Gln Cys Glu Pro Thr Ser Leu Pro 
1               5                   10                  15      


Pro Gly Pro Pro Ala Gly Arg Arg His Leu Pro Leu Ser Arg Arg Arg 
            20                  25                  30          


Arg Glu Met Ser Ser Asn Lys Glu Gln Arg Ser Ala Val Phe Val Ile 
        35                  40                  45              


Leu Phe Ala Leu Ile Thr Ile Leu Ile Leu Tyr Ser Ser Asn Ser Ala 
    50                  55                  60                  


Asn Glu Val Phe His Tyr Gly Ser Leu Arg Gly Arg Ser Arg Arg Pro 
65                  70                  75                  80  


Val Asn Leu Lys Lys Trp Ser Ile Thr Asp Gly Tyr Val Pro Ile Leu 
                85                  90                  95      


Gly Asn Lys Thr Leu Pro Ser Arg Cys His Gln Cys Val Ile Val Ser 
            100                 105                 110         


Ser Ser Ser His Leu Leu Gly Thr Lys Leu Gly Pro Glu Ile Glu Arg 
        115                 120                 125             


Ala Glu Cys Thr Ile Arg Met Asn Asp Ala Pro Thr Thr Gly Tyr Ser 
    130                 135                 140                 


Ala Asp Val Gly Asn Lys Thr Thr Tyr Arg Val Val Ala His Ser Ser 
145                 150                 155                 160 


Val Phe Arg Val Leu Arg Arg Pro Gln Glu Phe Val Asn Arg Thr Pro 
                165                 170                 175     


Glu Thr Val Phe Ile Phe Trp Gly Pro Pro Ser Lys Met Gln Lys Pro 
            180                 185                 190         


Gln Gly Ser Leu Val Arg Val Ile Gln Arg Ala Gly Leu Val Phe Pro 
        195                 200                 205             


Asn Met Glu Ala Tyr Ala Val Ser Pro Gly Arg Met Arg Gln Phe Asp 
    210                 215                 220                 


Asp Leu Phe Arg Gly Glu Thr Gly Lys Asp Arg Glu Lys Ser His Ser 
225                 230                 235                 240 


Trp Leu Ser Thr Gly Trp Phe Thr Met Val Ile Ala Val Glu Leu Cys 
                245                 250                 255     


Asp His Val His Val Tyr Gly Met Val Pro Pro Asn Tyr Cys Ser Gln 
            260                 265                 270         


Arg Pro Arg Leu Gln Arg Met Pro Tyr His Tyr Tyr Glu Pro Lys Gly 
        275                 280                 285             


Pro Asp Glu Cys Val Thr Tyr Ile Gln Asn Glu His Ser Arg Lys Gly 
    290                 295                 300                 


Asn His His Arg Phe Ile Thr Glu Lys Arg Val Phe Ser Ser Trp Ala 
305                 310                 315                 320 


Gln Leu Tyr Gly Ile Thr Phe Ser His Pro Ser Trp Thr 
                325                 330             


<210>  3409
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SIA7F__Homo_sapiens__AAH06564

<400>  3409
auggcuugcu cgaggccccc cagccagugu gaacccacau cccugccccc agggccaccu       60

gcaggacgcc gacaccuacc ccucagcaga cgccggagag aaaugaguag caacaaagag      120

cagcggucag caguguucgu gauccucuuu gcccucauca ccauccucau ccucuacagc      180

uccaacagug ccaaugaggu cuuccauuac ggcucccugc ggggccguag ccgccgaccu      240

gucaaccuca agaaguggag caucacugac ggcuaugucc ccauucucgg caacaagaca      300

cugcccucuc ggugccacca gugugugauu gucagcagcu ccagccaccu gcugggcacc      360

aagcugggcc cugagaucga gcgggcugag uguacaaucc gcaugaauga ugcacccacc      420

acuggcuacu cagcugaugu gggcaacaag accaccuacc gcgucguggc ccauuccagu      480

guguuccgcg ugcugaggag gccccaggag uuugucaacc ggaccccuga aaccguguuc      540

aucuucuggg ggcccccgag caagaugcag aagccccagg gcagccucgu gcgugugauc      600

cagcgagcgg gccugguguu ccccaacaug gaagcauaug ccgucucucc cggccgcaug      660

cggcaauuug acgaccucuu ccggggugag acgggcaagg acagggagaa gucucauucg      720

ugguugagca caggcugguu uaccauggug aucgcggugg aguuguguga ccacgugcau      780

gucuauggca uggucccccc caacuacugc agccagcggc cccgccucca gcgcaugccc      840

uaccacuacu acgagcccaa ggggccggac gaauguguca ccuacaucca gaaugagcac      900

agucgcaagg gcaaccacca ccgcuucauc accgagaaaa gggucuucuc aucgugggcc      960

cagcuguaug gcaucaccuu cucccacccc uccuggaccu ag                        1002


<210>  3410
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SIA7F__Homo_sapiens__AAH06564

<400>  3410
auggccugca gccggccccc gucccagugc gagcccacca gccugccgcc cggcccgccc       60

gccgggcgcc gccaccuccc ccugucccgg cgccggcgcg agaugagcuc caacaaggag      120

cagcggagcg cgguguucgu cauccuguuc gcccucauca ccauccugau ccuguacucc      180

agcaacuccg ccaacgaggu guuccacuac ggcagccucc gcgggcgguc ccgccggccc      240

gugaaccuga agaaguggag caucacggac ggcuacgucc ccauccuggg gaacaagacc      300

cuccccuccc gcugccacca gugcgugauc gugagcucca gcucccaccu ccugggcacc      360

aagcugggcc ccgagaucga gcgggccgag ugcaccaucc gcaugaacga cgcccccacg      420

accggguaca gcgcggacgu cggcaacaag accaccuacc gggugguggc ccacuccagc      480

gucuuccgcg ugcugcggcg cccgcaggag uucgugaacc ggacgcccga gaccgucuuc      540

aucuucuggg ggccgcccag caagaugcag aagccccagg gcucccuggu gcgcgugauc      600

cagcgggccg ggcucgucuu ccccaacaug gaggccuacg cggugagccc cggccgcaug      660

cgccaguucg acgaccuguu ccggggcgag accgggaagg accgcgagaa gucccacagc      720

uggcugucca ccggcugguu cacgauggug aucgccgucg agcucugcga ccacgugcac      780

guguacggga uggugccccc gaacuacugc agccagcggc cccgccugca gcggaugccc      840

uaccacuacu acgagcccaa gggcccggac gagugcguca ccuacaucca gaacgagcac      900

ucccgcaagg gcaaccacca ccgguucauc accgagaagc gcguguucag cuccugggcc      960

cagcuguacg ggaucaccuu cagccacccc uccuggacgu ga                        1002


<210>  3411
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SIA7F__Homo_sapiens__AAH06564

<400>  3411
auggccugcu cccgcccccc cucccagugc gagcccaccu cccucccccc cggccccccc       60

gccggccgcc gccaccuccc ccucucccgc cgccgccgcg agauguccuc caacaaggag      120

cagcgcuccg ccgucuucgu cauccucuuc gcccucauca ccauccucau ccucuacucc      180

uccaacuccg ccaacgaggu cuuccacuac ggcucccucc gcggccgcuc ccgccgcccc      240

gucaaccuca agaagugguc caucaccgac ggcuacgucc ccauccucgg caacaagacc      300

cuccccuccc gcugccacca gugcgucauc gucuccuccu ccucccaccu ccucggcacc      360

aagcucggcc ccgagaucga gcgcgccgag ugcaccaucc gcaugaacga cgcccccacc      420

accggcuacu ccgccgacgu cggcaacaag accaccuacc gcgucgucgc ccacuccucc      480

gucuuccgcg uccuccgccg cccccaggag uucgucaacc gcacccccga gaccgucuuc      540

aucuucuggg gcccccccuc caagaugcag aagccccagg gcucccucgu ccgcgucauc      600

cagcgcgccg gccucgucuu ccccaacaug gaggccuacg ccgucucccc cggccgcaug      660

cgccaguucg acgaccucuu ccgcggcgag accggcaagg accgcgagaa gucccacucc      720

uggcucucca ccggcugguu caccaugguc aucgccgucg agcucugcga ccacguccac      780

gucuacggca uggucccccc caacuacugc ucccagcgcc cccgccucca gcgcaugccc      840

uaccacuacu acgagcccaa gggccccgac gagugcguca ccuacaucca gaacgagcac      900

ucccgcaagg gcaaccacca ccgcuucauc accgagaagc gcgucuucuc cuccugggcc      960

cagcucuacg gcaucaccuu cucccacccc uccuggaccu ga                        1002


<210>  3412
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SIA7F__Homo_sapiens__AAH06564

<400>  3412
auggccugca gcagaccccc uucccagugu gagccaaccu cucugccgcc cggcccucca       60

gcugggaggc ggcaccuccc ccuuucacgc cgacguagag aaaugaguag caacaaggag      120

caaagguccg caguguucgu cauccuguuu gccuugauua caauauuaau ccuguacucu      180

ucaaauucgg cgaacgaagu uuuccauuau ggaagccuac ggggucgcag uagaaggccu      240

gugaaucuca aaaagugguc cauuacugac ggcuacguac caauccuggg gaacaaaacg      300

cuucccucuc ggugccacca gugugugauu gucagcuccu caagucaucu guugggaacc      360

aagcucggcc cugagaucga acgcgcugag ugcacaauac gaaugaauga ugccccaacu      420

accgguuaua gcgcagacgu ggggaacaaa acaaccuaca gaguuguggc ccacucuucc      480

gucuuuaggg ugcugcggcg uccgcaggag uucguaaauc gcacucccga aacaguuuuu      540

aucuucuggg gaccuccauc aaagaugcag aagccccaag gcagccuggu gagagucauu      600

cagagggcug gccucguguu uccuaacaug gaggcauaug ccgugagucc agggcggaug      660

cgacaguucg augacuuauu ucgcggagaa accgguaaag auagagagaa gucucauucc      720

uggcugagca cgggcugguu cacuaugguc aucgcuguug agcuuuguga ccacgugcac      780

guauacggga uggugccccc gaauuauugc ucgcagaggc cucgguugca acgcaugccc      840

uaccauuacu augaaccaaa aggaccugau gaguguguca ccuacauuca gaacgaacac      900

ucuagaaagg gcaaucauca cagguuuauc acagagaaac guguguucuc cucaugggcc      960

cagcuguaug guauaacuuu uagucacccc agcuggaccu ga                        1002


<210>  3413
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SIA7F__Homo_sapiens__AAH06564

<400>  3413
auggccugca gcagaccccc cagccagugc gagcccacca gccugccccc cggccccccc       60

gccggcagaa gacaccugcc ccugagcaga agaagaagag agaugagcag caacaaggag      120

cagagaagcg ccguguucgu gauccuguuc gcccugauca ccauccugau ccuguacagc      180

agcaacagcg ccaacgaggu guuccacuac ggcagccuga gaggcagaag cagaagaccc      240

gugaaccuga agaaguggag caucaccgac ggcuacgugc ccauccuggg caacaagacc      300

cugcccagca gaugccacca gugcgugauc gugagcagca gcagccaccu gcugggcacc      360

aagcugggcc ccgagaucga gagagccgag ugcaccauca gaaugaacga cgcccccacc      420

accggcuaca gcgccgacgu gggcaacaag accaccuaca gagugguggc ccacagcagc      480

guguucagag ugcugagaag accccaggag uucgugaaca gaacccccga gaccguguuc      540

aucuucuggg gcccccccag caagaugcag aagccccagg gcagccuggu gagagugauc      600

cagagagccg gccugguguu ccccaacaug gaggccuacg ccgugagccc cggcagaaug      660

agacaguucg acgaccuguu cagaggcgag accggcaagg acagagagaa gagccacagc      720

uggcugagca ccggcugguu caccauggug aucgccgugg agcugugcga ccacgugcac      780

guguacggca uggugccccc caacuacugc agccagagac ccagacugca gagaaugccc      840

uaccacuacu acgagcccaa gggccccgac gagugcguga ccuacaucca gaacgagcac      900

agcagaaagg gcaaccacca cagauucauc accgagaaga gaguguucag cagcugggcc      960

cagcuguacg gcaucaccuu cagccacccc agcuggaccu ga                        1002


<210>  3414
<211>  1002
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SIA7F__Homo_sapiens__AAH06564

<400>  3414
auggccugca gcagaccccc uucccagugu gagccgaccu cucugccccc ugggcccccu       60

gcuggccggc gccaccuccc ccugagcaga cggcgcagag aaauguccuc uaacaaggag      120

caacggagcg ccguguucgu cauccuuuuu gcgcugauua caauccucau ucuguacucc      180

ucuaauagcg cuaacgaagu uuuccauuau ggaucccuuc gcggcagaag ccggcgcccu      240

gugaaucuga aaaagugguc uaucacggac ggguacgugc cgauucucgg aaacaaaacc      300

cugcccucca gaugccacca gugugucauc gugucuagcu ccagccaucu gcucggcaca      360

aagcuggggc cugagaucga acgggccgag ugcaccauuc gcaugaauga ugcccccaca      420

accggauauu cugcugacgu uggcaacaaa acaaccuaca gaguggucgc ccacuccagc      480

guguuucggg uucuucgcag accucaggag uucgugaauc ggacgcccga aaccgucuuu      540

aucuucuggg gcccgccuuc caagaugcag aagccccaag ggucucuggu gagagugauu      600

cagcgcgcug gacucgucuu uccuaacaug gaggccuaug cgguuagccc cggccggaug      660

agacaguucg augaccuguu ucgcggggaa acaggaaaag aucgggagaa gucccauagc      720

uggcuuucua ccggcugguu cacaauggug aucgccgugg agcuguguga ccacguccac      780

guguacggga ugguuccccc uaauuauugc ucccagagac cgcgccucca acggaugccc      840

uaccauuacu augaaccuaa aggacccgau gaguguguga ccuacauuca gaacgaacac      900

agcagaaagg gcaaucauca ccgcuuuauc acggagaaac gggucuucuc uagcugggcu      960

cagcuguaug gcauuacauu uucccacccu ucuuggaccu ga                        1002


<210>  3415
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SIA8A__Homo_sapiens__Q92185

<400>  3415

Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met 
1               5                   10                  15      


Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala 
            20                  25                  30          


Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val 
        35                  40                  45              


Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln 
    50                  55                  60                  


Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys 
65                  70                  75                  80  


Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys 
                85                  90                  95      


Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu 
            100                 105                 110         


Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala 
        115                 120                 125             


Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly 
    130                 135                 140                 


Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn 
145                 150                 155                 160 


Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys 
                165                 170                 175     


Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile 
            180                 185                 190         


Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp 
        195                 200                 205             


Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser 
    210                 215                 220                 


Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser 
225                 230                 235                 240 


Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu 
                245                 250                 255     


Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg 
            260                 265                 270         


Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu 
        275                 280                 285             


Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu 
    290                 295                 300                 


Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly 
305                 310                 315                 320 


Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys 
                325                 330                 335     


Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu 
            340                 345                 350         


Gln Pro Thr Ser 
        355     


<210>  3416
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SIA8A__Homo_sapiens__AAC37586

<400>  3416
augagccccu gcgggcgggc ccggcgacaa acguccagag gggccauggc uguacuggcg       60

uggaaguucc cgcggacccg gcugcccaug ggagccagug cccucugugu cgugguccuc      120

uguuggcucu acaucuuccc cgucuaccgg cugcccaacg agaaagagau cgugcagggg      180

gugcugcaac agggcacggc guggaggagg aaccagaccg cggccagagc guucaggaaa      240

caaauggaag acugcugcga cccugcccau cucuuugcua ugacuaaaau gaauuccccu      300

auggggaaga gcauguggua ugacggggag uuuuuauacu cauucaccau ugacaauuca      360

acuuacucuc ucuucccaca ggcaacccca uuccagcugc cauugaagaa augcgcggug      420

gugggaaaug gugggauucu gaagaagagu ggcuguggcc gucaaauaga ugaagcaaau      480

uuugucaugc gaugcaaucu cccuccuuug ucaagugaau acacuaagga uguuggaucc      540

aaaagucagu uagugacagc uaaucccagc auaauucggc aaagguuuca gaaccuucug      600

ugguccagaa agacauuugu ggacaacaug aaaaucuaua accacaguua caucuacaug      660

ccugccuuuu cuaugaagac aggaacagag ccaucuuuga ggguuuauua uacacuguca      720

gauguuggug ccaaucaaac agugcuguuu gccaacccca acuuucugcg uagcauugga      780

aaguucugga aaaguagagg aauccaugcc aagcgccugu ccacaggacu uuuucuggug      840

agcgcagcuc ugggucucug ugaagaggug gccaucuaug gcuucuggcc cuucucugug      900

aauaugcaug agcagcccau cagccaccac uacuaugaca acgucuuacc cuuuucuggc      960

uuccaugcca ugcccgagga auuucuccaa cucugguauc uucauaaaau cggugcacug     1020

agaaugcagc uggacccaug ugaagauacc ucacuccagc ccacuuccua g              1071


<210>  3417
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SIA8A__Homo_sapiens__AAC37586

<400>  3417
augagccccu gcggccgcgc ccggcgccag accucccgcg gggccauggc ggugcuggcc       60

uggaaguucc cgcggacccg gcuccccaug ggcgccagcg cccugugcgu cguggugcug      120

ugcuggcucu acaucuuccc cgucuaccgc cugcccaacg agaaggagau cgugcagggg      180

gugcugcagc agggcacggc cuggcggcgc aaccagaccg cggcccgggc cuuccgcaag      240

cagauggagg acugcugcga cccggcccac cucuucgcga ugaccaagau gaacuccccc      300

augggcaaga gcauguggua cgacggggag uuccuguacu ccuucaccau cgacaacagc      360

acguacuccc uguuccccca ggccaccccc uuccagcucc cgcugaagaa gugcgccguc      420

gugggcaacg ggggcauccu gaagaagucc gggugcggcc ggcagaucga cgaggccaac      480

uucgugaugc gcugcaaccu cccgccccug agcagcgagu acaccaagga cgucgggucc      540

aagagccagc uggugaccgc caaccccucc aucauccggc agcgcuucca gaaccuccug      600

uggagccgga agacguucgu ggacaacaug aagaucuaca accacuccua caucuacaug      660

cccgcguuca gcaugaagac cggcaccgag cccucccugc gcgucuacua cacccucagc      720

gacgugggcg ccaaccagac ggugcuguuc gccaacccca acuuccugcg guccaucggg      780

aaguucugga agucccgcgg cauccacgcc aagcggcuca gcaccgggcu guuccugguc      840

agcgccgcgc ucggccugug cgaggaggug gccaucuacg gcuucuggcc cuucagcgug      900

aacaugcacg agcagccgau cucccaccac uacuacgaca acguccugcc cuucagcggg      960

uuccacgcca ugcccgagga guuccuccag cugugguacc ugcacaagau cggcgcccuc     1020

cgcaugcagc uggaccccug cgaggacacc ucccugcagc cgaccagcug a              1071


<210>  3418
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SIA8A__Homo_sapiens__AAC37586

<400>  3418
augucccccu gcggccgcgc ccgccgccag accucccgcg gcgccauggc cguccucgcc       60

uggaaguucc cccgcacccg ccuccccaug ggcgccuccg cccucugcgu cgucguccuc      120

ugcuggcucu acaucuuccc cgucuaccgc cuccccaacg agaaggagau cguccagggc      180

guccuccagc agggcaccgc cuggcgccgc aaccagaccg ccgcccgcgc cuuccgcaag      240

cagauggagg acugcugcga ccccgcccac cucuucgcca ugaccaagau gaacuccccc      300

augggcaagu ccauguggua cgacggcgag uuccucuacu ccuucaccau cgacaacucc      360

accuacuccc ucuuccccca ggccaccccc uuccagcucc cccucaagaa gugcgccguc      420

gucggcaacg gcggcauccu caagaagucc ggcugcggcc gccagaucga cgaggccaac      480

uucgucaugc gcugcaaccu ccccccccuc uccuccgagu acaccaagga cgucggcucc      540

aagucccagc ucgucaccgc caaccccucc aucauccgcc agcgcuucca gaaccuccuc      600

uggucccgca agaccuucgu cgacaacaug aagaucuaca accacuccua caucuacaug      660

cccgccuucu ccaugaagac cggcaccgag cccucccucc gcgucuacua cacccucucc      720

gacgucggcg ccaaccagac cguccucuuc gccaacccca acuuccuccg cuccaucggc      780

aaguucugga agucccgcgg cauccacgcc aagcgccucu ccaccggccu cuuccucguc      840

uccgccgccc ucggccucug cgaggagguc gccaucuacg gcuucuggcc cuucuccguc      900

aacaugcacg agcagcccau cucccaccac uacuacgaca acguccuccc cuucuccggc      960

uuccacgcca ugcccgagga guuccuccag cucugguacc uccacaagau cggcgcccuc     1020

cgcaugcagc ucgaccccug cgaggacacc ucccuccagc ccaccuccug a              1071


<210>  3419
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SIA8A__Homo_sapiens__AAC37586

<400>  3419
augagccccu gcggcagagc caggcggcag accucccgcg gggcuauggc agugcuggcc       60

uggaaguucc cucgaacacg ucucccaaug ggagcgucug cucuuugugu cguugugcug      120

ugcugguugu acaucuuucc gguauauaga uuacccaacg agaaagaaau ugugcaaggu      180

guccugcagc agggcacugc cuggaggcgg aaucagacgg cagcccgcgc uuucagaaag      240

caaauggagg acuguugcga uccugcacac cuauuugcca ugaccaaaau gaacucacca      300

auggggaaga guauguggua cgacggagag uuccucuaua gcuuuacaau agauaauucc      360

acuuacucuc uguuccccca ggcuaccccu uuucagcuuc cacugaaaaa gugugccgug      420

guuggcaacg gugggaucuu gaagaaaucg ggaugcggca ggcagauuga cgaagcgaau      480

uucgugaugc gguguaaccu gcccccucuc ucaagcgaau auacaaagga ugucggcagu      540

aaaucccaac uggugaccgc aaauccaucu aucauucgcc agcgauuuca gaaccucuua      600

uggagcagaa agacuuucgu agacaauaug aaaaucuaca accauuccua uauauacaug      660

ccggccuuuu caaugaagac agggaccgag cccagucuga ggguuuacua uacgcuuagc      720

gaugugggag cuaaucagac ugucuuguuc gccaacccua auuuucugcg gucuaucggu      780

aaguucugga aaucccgugg cauucacgca aagcgccuau caaccggacu cuuccuggug      840

agcgcugccc uugggcugug cgaggaagug gcgaucuacg gcuuuuggcc auucaguguc      900

aacaugcaug agcaacccau uucucaccau uauuacgaca auguuuugcc uuuuuccggu      960

uuccacgcca ugccagaaga guuucuccag cugugguauu uacacaaaau cggggcacug     1020

agaaugcagc ucgaucccug ugaggacaca agccuucaac cgacuucgug a              1071


<210>  3420
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SIA8A__Homo_sapiens__AAC37586

<400>  3420
augagccccu gcggcagagc cagaagacag accagcagag gcgccauggc cgugcuggcc       60

uggaaguucc ccagaaccag acugcccaug ggcgccagcg cccugugcgu gguggugcug      120

ugcuggcugu acaucuuccc cguguacaga cugcccaacg agaaggagau cgugcagggc      180

gugcugcagc agggcaccgc cuggagaaga aaccagaccg ccgccagagc cuucagaaag      240

cagauggagg acugcugcga ccccgcccac cuguucgcca ugaccaagau gaacagcccc      300

augggcaaga gcauguggua cgacggcgag uuccuguaca gcuucaccau cgacaacagc      360

accuacagcc uguuccccca ggccaccccc uuccagcugc cccugaagaa gugcgccgug      420

gugggcaacg gcggcauccu gaagaagagc ggcugcggca gacagaucga cgaggccaac      480

uucgugauga gaugcaaccu gcccccccug agcagcgagu acaccaagga cgugggcagc      540

aagagccagc uggugaccgc caaccccagc aucaucagac agagauucca gaaccugcug      600

uggagcagaa agaccuucgu ggacaacaug aagaucuaca accacagcua caucuacaug      660

cccgccuuca gcaugaagac cggcaccgag cccagccuga gaguguacua cacccugagc      720

gacgugggcg ccaaccagac cgugcuguuc gccaacccca acuuccugag aagcaucggc      780

aaguucugga agagcagagg cauccacgcc aagagacuga gcaccggccu guuccuggug      840

agcgccgccc ugggccugug cgaggaggug gccaucuacg gcuucuggcc cuucagcgug      900

aacaugcacg agcagcccau cagccaccac uacuacgaca acgugcugcc cuucagcggc      960

uuccacgcca ugcccgagga guuccugcag cugugguacc ugcacaagau cggcgcccug     1020

agaaugcagc uggaccccug cgaggacacc agccugcagc ccaccagcug a              1071


<210>  3421
<211>  1071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SIA8A__Homo_sapiens__AAC37586

<400>  3421
augagccccu gcggcagagc ccggcgccag accuccagag gggcuauggc cgugcuggcg       60

uggaaguucc cucggacacg ccucccgaug ggagcuucug cccugugugu cguugugcuu      120

ugcuggcugu acaucuuucc cguguauaga cucccuaacg agaaagaaau uguccaaggc      180

gugcugcagc aggggacggc cuggcggcgc aaucagaccg cugccagagc uuuccggaag      240

caaauggagg acuguugcga ucccgcccac cuuuuugcga ugacaaaaau gaacagcccu      300

augggaaagu ccauguggua cgacggcgag uuccuguauu cuuuuaccau cgauaauagc      360

acauacuccc ucuuccccca ggccaccccu uuucagcugc cgcugaaaaa gugugcuguu      420

guggggaacg gaggcauucu caagaaaucu ggcugcgggc gccagaucga cgaagccaau      480

uucgucauga gauguaaccu gcccccucuu agcuccgaau auacaaagga ugugggaagc      540

aaaucucaac ugguuaccgc uaaucccucc auuauccggc agcgcuuuca gaaccuccug      600

uggagcagaa agacguucgu ggacaauaug aaaaucuaca accauucuua uauuuacaug      660

ccugccuuuu ccaugaagac cggcacagag cccagccuuc gggucuacua uacccugucu      720

gauguggggg cgaaucagac aguccucuuc gccaacccga auuuucugcg cuccaucgga      780

aaguucugga aaagcagagg cauucacgcu aagcggcugu ccaccggacu cuuccuggug      840

ucugccgcuc uugggcugug cgaggaaguu gccaucuacg gcuuuuggcc uuucagcgug      900

aacaugcaug agcaacccau uucccaccau uauuacgaca augugcuccc uuuuagcggc      960

uuccacgcca ugcccgaaga guuucugcag cuuugguauc ugcacaaaau cggggcucuc     1020

agaaugcagc uggaucccug ugaggacacg ucucugcaac cuacauccug a              1071


<210>  3422
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SIAT9__Homo_sapiens__Q9UNP4

<400>  3422

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  3423
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SIAT9__Homo_sapiens__BAG50894

<400>  3423
augcggacga aggcggcggg cugcgcggag cggcgucccc ugcagccgcg gaccgaggca       60

gcggcggcac cugccggccg agcaaugcca agugaguaca ccuaugugaa acugagaagu      120

gauugcucga ggccuucccu gcaaugguac acccgagcuc aaagcaagau gagaaggccc      180

agcuuguuau uaaaagacau ccucaaaugu acauugcuug uguuuggagu guggauccuu      240

uauauccuca aguuaaauua uacuacugaa gaaugugaca ugaaaaaaau gcauuaugug      300

gacccugacc auguaaagag agcucagaaa uaugcucagc aagucuugca gaaggaaugu      360

cgucccaagu uugccaagac aucaauggcg cuguuauuug agcacaggua uagcguggac      420

uuacucccuu uugugcagaa ggcccccaaa gacagugaag cugaguccaa guacgauccu      480

ccuuuugggu uccggaaguu cuccaguaaa guccagaccc ucuuggaacu cuugccagag      540

cacgaccucc cugaacacuu gaaagccaag accugucggc gcuguguggu uauuggaagc      600

ggaggaauac ugcacggauu agaacugggc cacacccuga accaguucga uguugugaua      660

agguuaaaca gugcaccagu ugagggauau ucagaacaug uuggaaauaa aacuacuaua      720

aggaugacuu auccagaggg cgcaccacug ucugaccuug aauauuauuc caaugacuua      780

uuuguugcug uuuuauuuaa gaguguugau uucaacuggc uucaagcaau gguaaaaaag      840

gaaacccugc cauucugggu acgacucuuc uuuuggaagc agguggcaga aaaaauccca      900

cugcagccaa aacauuucag gauuuugaau ccaguuauca ucaaagagac ugccuuugac      960

auccuucagu acucagagcc ucagucaagg uucuggggcc gagauaagaa cguccccaca     1020

aucgguguca uugccguugu cuuagccaca caucugugcg augaagucag uuuggcgggu     1080

uuuggauaug accucaauca acccagaaca ccuuugcacu acuucgacag ucaaugcaug     1140

gcugcuauga acuuucagac caugcauaau gugacaacgg aaaccaaguu ccucuuaaag     1200

cuggucaaag agggaguggu gaaagaucuc aguggaggca uugaucguga auuuuga        1257


<210>  3424
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SIAT9__Homo_sapiens__BAG50894

<400>  3424
augcgcacca aggccgccgg cugcgcggag cggcgccccc ugcagccgcg gaccgaggcc       60

gccgccgccc ccgcggggcg cgccaugccc agcgaguaca cguacgugaa gcuccggucc      120

gacugcagcc gccccucccu gcagugguac acccgggccc agagcaagau gcgccggccg      180

ucccugcucc ugaaggacau ccugaagugc acccuccugg ucuucggcgu guggauccug      240

uacauccuca agcugaacua caccacggag gagugcgaca ugaagaagau gcacuacgug      300

gaccccgacc acgucaagcg cgcccagaag uacgcgcagc agguccugca gaaggagugc      360

cggcccaagu ucgccaagac cagcauggcc cuccuguucg agcaccgcua cuccguggac      420

cugcuccccu ucgugcagaa ggccccgaag gacagcgagg ccgaguccaa guacgacccg      480

cccuucgggu uccggaaguu cagcuccaag gugcagaccc ugcuggagcu ccugcccgag      540

cacgaccugc ccgagcaccu caaggcgaag accugccgcc ggugcguggu caucggcagc      600

gggggcaucc ugcacggccu ggagcucggg cacacgcuga accaguucga cguggugauc      660

cgccugaacu ccgcccccgu cgagggcuac agcgagcacg uggggaacaa gaccaccauc      720

cggaugaccu accccgaggg cgcgccccuc uccgaccugg aguacuacag caacgaccug      780

uucguggccg uccucuucaa guccguggac uucaacuggc ugcaggccau ggugaagaag      840

gagacgcugc cguucugggu ccgccucuuc uucuggaagc aggucgccga gaagaucccc      900

cugcagccca agcacuuccg gauccugaac cccgugauca ucaaggagac cgccuucgac      960

auccuccagu acagcgagcc gcagucccgc uucugggggc gggacaagaa cgugcccacc     1020

aucggcguga ucgccguggu ccuggccacc caccugugcg acgaggugag ccucgccggc     1080

uucggguacg accugaacca gccccgcacg ccccugcacu acuucgacag ccagugcaug     1140

gcggccauga acuuccagac caugcacaac gucaccaccg agacgaaguu ccuccugaag     1200

cuggugaagg agggcguggu caaggaccuc uccgggggca ucgaccgcga guucuga        1257


<210>  3425
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SIAT9__Homo_sapiens__BAG50894

<400>  3425
augcgcacca aggccgccgg cugcgccgag cgccgccccc uccagccccg caccgaggcc       60

gccgccgccc ccgccggccg cgccaugccc uccgaguaca ccuacgucaa gcuccgcucc      120

gacugcuccc gccccucccu ccagugguac acccgcgccc aguccaagau gcgccgcccc      180

ucccuccucc ucaaggacau ccucaagugc acccuccucg ucuucggcgu cuggauccuc      240

uacauccuca agcucaacua caccaccgag gagugcgaca ugaagaagau gcacuacguc      300

gaccccgacc acgucaagcg cgcccagaag uacgcccagc agguccucca gaaggagugc      360

cgccccaagu ucgccaagac cuccauggcc cuccucuucg agcaccgcua cuccgucgac      420

cuccuccccu ucguccagaa ggcccccaag gacuccgagg ccgaguccaa guacgacccc      480

cccuucggcu uccgcaaguu cuccuccaag guccagaccc uccucgagcu ccuccccgag      540

cacgaccucc ccgagcaccu caaggccaag accugccgcc gcugcgucgu caucggcucc      600

ggcggcaucc uccacggccu cgagcucggc cacacccuca accaguucga cgucgucauc      660

cgccucaacu ccgcccccgu cgagggcuac uccgagcacg ucggcaacaa gaccaccauc      720

cgcaugaccu accccgaggg cgccccccuc uccgaccucg aguacuacuc caacgaccuc      780

uucgucgccg uccucuucaa guccgucgac uucaacuggc uccaggccau ggucaagaag      840

gagacccucc ccuucugggu ccgccucuuc uucuggaagc aggucgccga gaagaucccc      900

cuccagccca agcacuuccg cauccucaac cccgucauca ucaaggagac cgccuucgac      960

auccuccagu acuccgagcc ccagucccgc uucuggggcc gcgacaagaa cguccccacc     1020

aucggcguca ucgccgucgu ccucgccacc caccucugcg acgaggucuc ccucgccggc     1080

uucggcuacg accucaacca gccccgcacc ccccuccacu acuucgacuc ccagugcaug     1140

gccgccauga acuuccagac caugcacaac gucaccaccg agaccaaguu ccuccucaag     1200

cucgucaagg agggcgucgu caaggaccuc uccggcggca ucgaccgcga guucuga        1257


<210>  3426
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SIAT9__Homo_sapiens__BAG50894

<400>  3426
augagaacca aggccgcugg cugcgcagaa aggcggcccc ugcagccucg cacagaagcc       60

gcggcugccc cagcagggcg agccaugccg agcgaguaca cuuaugugaa acuccguucc      120

gacuguucua gacccucacu ucaaugguac acgagggcuc agaguaagau gcggcgcccu      180

agccuguugu uaaaagauau ccugaagugc acccuacucg ucuucggagu uuggauucug      240

uauauacuua aacugaacua cacaacugaa gagugugaca ugaagaagau gcacuaugug      300

gauccagacc auguaaaaag agcacagaag uacgcccagc aaguguugca gaaagaaugc      360

aggcccaagu uugcuaaaac cuccauggcc cuccuguucg agcaccggua uucugucgau      420

cugcucccuu uugugcagaa ggcgccaaag gacucggagg cagaaucaaa auacgauccc      480

ccuuucgguu uucgcaaguu cagcaguaaa guucagacau uacuggagcu uuugccagaa      540

caugaccugc cggagcaccu aaaggccaaa accugucgaa gaugcguggu caucggcucc      600

gggggcauuc uccauggacu ggagcuuggu cacacucuga aucaauuuga ugugguaauc      660

agguugaacu cugcucccgu ugaaggguac agcgagcacg ugggaaauaa gacaaccauu      720

cggaugacgu auccugaagg cgccccacuc uccgaccugg aguacuauuc aaacgauuua      780

uucgucgcag ugcuguuuaa aaguguggac uucaauuggc uccaggcuau ggucaagaag      840

gaaacucuuc ccuuuugggu ucgucuguuc uuuuggaaac agguggccga gaagaucccu      900

uugcagccaa aacauuuccg cauacuaaac cccguaauca uuaaggagac cgcguucgau      960

auccugcaau acagcgaacc gcagucuaga uuuuggggca gggacaaaaa ugugccuaca     1020

auugggguca ucgccguggu ucucgcaacu caccugugug acgagguguc ccuugcugga     1080

uucgguuaug aucugaacca gccccggacc ccauugcauu acuuugacuc acaaugcaug     1140

gccgcuauga auuuccagac aaugcacaac gucaccacgg aaacuaaguu ucuccugaag     1200

uuagugaaag agggcguagu uaaggaucug agcgggggaa uagaccgaga guucuga        1257


<210>  3427
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SIAT9__Homo_sapiens__BAG50894

<400>  3427
augagaacca aggccgccgg cugcgccgag agaagacccc ugcagcccag aaccgaggcc       60

gccgccgccc ccgccggcag agccaugccc agcgaguaca ccuacgugaa gcugagaagc      120

gacugcagca gacccagccu gcagugguac accagagccc agagcaagau gagaagaccc      180

agccugcugc ugaaggacau ccugaagugc acccugcugg uguucggcgu guggauccug      240

uacauccuga agcugaacua caccaccgag gagugcgaca ugaagaagau gcacuacgug      300

gaccccgacc acgugaagag agcccagaag uacgcccagc aggugcugca gaaggagugc      360

agacccaagu ucgccaagac cagcauggcc cugcuguucg agcacagaua cagcguggac      420

cugcugcccu ucgugcagaa ggcccccaag gacagcgagg ccgagagcaa guacgacccc      480

cccuucggcu ucagaaaguu cagcagcaag gugcagaccc ugcuggagcu gcugcccgag      540

cacgaccugc ccgagcaccu gaaggccaag accugcagaa gaugcguggu gaucggcagc      600

ggcggcaucc ugcacggccu ggagcugggc cacacccuga accaguucga cguggugauc      660

agacugaaca gcgcccccgu ggagggcuac agcgagcacg ugggcaacaa gaccaccauc      720

agaaugaccu accccgaggg cgccccccug agcgaccugg aguacuacag caacgaccug      780

uucguggccg ugcuguucaa gagcguggac uucaacuggc ugcaggccau ggugaagaag      840

gagacccugc ccuucugggu gagacuguuc uucuggaagc agguggccga gaagaucccc      900

cugcagccca agcacuucag aauccugaac cccgugauca ucaaggagac cgccuucgac      960

auccugcagu acagcgagcc ccagagcaga uucuggggca gagacaagaa cgugcccacc     1020

aucggcguga ucgccguggu gcuggccacc caccugugcg acgaggugag ccuggccggc     1080

uucggcuacg accugaacca gcccagaacc ccccugcacu acuucgacag ccagugcaug     1140

gccgccauga acuuccagac caugcacaac gugaccaccg agaccaaguu ccugcugaag     1200

cuggugaagg agggcguggu gaaggaccug agcggcggca ucgacagaga guucuga        1257


<210>  3428
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SIAT9__Homo_sapiens__BAG50894

<400>  3428
augagaacca aggccgcugg cugcgccgaa cggcgccccc ugcagccuag aacagaagcg       60

gcugccgccc cggcugggcg ggccaugccc agcgaguaca cguaugugaa acuccgcucc      120

gacuguucua gaccuagccu gcaaugguac acccgggcuc aguccaagau gcgcagaccc      180

ucucuucugc ucaaagauau ccugaagugc acacuucugg ucuucggagu uuggauucuc      240

uauauccuga aacugaacua caccacagaa gagugugaca ugaagaagau gcacuaugug      300

gauccugacc augugaaacg ggcccagaag uacgcgcagc aaguccucca gaaagaaugc      360

cgccccaagu uugccaaaac cagcauggcu cugcuuuucg agcacagaua uuccguggau      420

cugcucccuu uuguucagaa ggccccgaag gacucugagg cugaaagcaa auacgauccc      480

ccuuucggcu uucggaaguu cuccagcaaa gugcagacac ugcuugagcu gcuccccgaa      540

caugaccugc cugagcaccu gaaggccaaa accugucgca gaugcgucgu gauugggucu      600

ggaggcaucc uccaugggcu ggagcuugga cacacgcuga aucaauuuga uguugugauu      660

cggcucaacu ccgcgcccgu cgaaggcuac agcgagcacg ugggcaauaa gaccacaauc      720

cgcaugaccu auccggaagg ggccccucug ucugaccuug aguacuauuc caacgaucug      780

uucguggcug uccucuuuaa aagcguugac uucaauuggc ugcaggccau ggugaagaag      840

gaaacacugc ccuuuugggu gagacucuuc uuuuggaaac aggucgcuga gaagaucccu      900

cugcagccca aacauuuccg gauucuuaac cccgugauca uuaaggagac cgccuucgau      960

auccugcaau acucugaacc ucaguccaga uuuuggggac gcgacaaaaa uguuccgacg     1020

auuggcguga ucgccgucgu gcucgcuaca caccugugug acgagguuag ccuugcgggg     1080

uucggauaug aucugaacca gccccggacc ccucuccauu acuuugacuc ccaaugcaug     1140

gccgcuauga auuuccagac aaugcacaac gugaccaccg aaacaaaguu ucugcugaag     1200

cucgucaaag agggcguggu caaggaucug ucugggggaa uugacagaga guucuga        1257


<210>  3429
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SIRT2/m__Homo_sapiens__A0A024R0G8

<400>  3429

Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu Glu Gly Val Ala Arg 
            20                  25                  30          


Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile Cys Leu Val Gly Ala 
        35                  40                  45              


Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe Arg Ser Pro Ser Thr 
    50                  55                  60                  


Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu Pro Tyr Pro Glu Ala 
65                  70                  75                  80  


Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro Glu Pro Phe Phe Ala 
                85                  90                  95      


Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys Pro Thr Ile Cys His 
            100                 105                 110         


Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu Leu Leu Arg Cys Tyr 
        115                 120                 125             


Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala Gly Leu Glu Gln Glu 
    130                 135                 140                 


Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr Ser His Cys Val Ser 
145                 150                 155                 160 


Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp Met Lys Glu Lys Ile 
                165                 170                 175     


Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys Gln Ser Leu Val Lys 
            180                 185                 190         


Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro Ala Arg Phe Phe Ser 
        195                 200                 205             


Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu Leu Leu Val Met Gly 
    210                 215                 220                 


Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu Ile Ser Lys Ala Pro 
225                 230                 235                 240 


Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu Lys Ala Gly Gln Ser 
                245                 250                 255     


Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly Gly Gly Met Asp Phe 
            260                 265                 270         


Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp Leu Gly Glu Cys Asp 
        275                 280                 285             


Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly Trp Lys Lys Glu Leu 
    290                 295                 300                 


Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile Asp Ala Gln Ser Gly 
305                 310                 315                 320 


Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser Pro Lys Lys Ser Pro 
                325                 330                 335     


Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu Arg Glu Lys Pro Gln 
            340                 345                 350         






<210>  3430
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SIRT2/m__Homo_sapiens__EAW56837

<400>  3430
auggacuucc ugcggaacuu auucucccag acgcucagcc ugggcagcca gaaggagcgu       60

cugcuggacg agcugaccuu ggaaggggug gcccgguaca ugcagagcga acgcugucgc      120

agagucaucu guuugguggg agcuggaauc uccacauccg caggcauccc cgacuuucgc      180

ucuccaucca ccggccucua ugacaaccua gagaaguacc aucuucccua cccagaggcc      240

aucuuugaga ucagcuauuu caagaaacau ccggaacccu ucuucgcccu cgccaaggaa      300

cucuauccug ggcaguucaa gccaaccauc ugucacuacu ucaugcgccu gcugaaggac      360

aaggggcuac uccugcgcug cuacacgcag aacauagaua cccuggagcg aauagccggg      420

cuggaacagg aggacuuggu ggaggcgcac ggcaccuucu acacaucaca cugcgucagc      480

gccagcugcc ggcacgaaua cccgcuaagc uggaugaaag agaagaucuu cucugaggug      540

acgcccaagu gugaagacug ucagagccug gugaagccug auaucgucuu uuuuggugag      600

agccucccag cgcguuucuu cuccuguaug cagucagacu uccugaaggu ggaccuccuc      660

cuggucaugg guaccuccuu gcaggugcag cccuuugccu cccucaucag caaggcaccc      720

cucuccaccc cucgccugcu caucaacaag gagaaagcug gccagucgga cccuuuccug      780

gggaugauua ugggccucgg aggaggcaug gacuuugacu ccaagaaggc cuacagggac      840

guggccuggc ugggugaaug cgaccagggc ugccuggccc uugcugagcu ccuuggaugg      900

aagaaggagc uggaggaccu uguccggagg gagcacgcca gcauagaugc ccagucgggg      960

gcgggggucc ccaaccccag cacuucagcu ucccccaaga aguccccgcc accugccaag     1020

gacgaggcca ggacaacaga gagggagaaa ccccaguga                            1059


<210>  3431
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SIRT2/m__Homo_sapiens__EAW56837

<400>  3431
auggacuucc ugcgcaaccu cuucagccag acccugagcc ugggcagcca gaaggagcgg       60

cuccuggacg agcugacccu cgagggggug gcccgcuaca ugcaguccga gcggugccgc      120

cgggucaucu gccugguggg cgccgggauc agcacguccg cgggcauccc cgacuuccgc      180

agccccucca ccgggcugua cgacaaccuc gagaaguacc accuccccua ccccgaggcc      240

aucuucgaga ucagcuacuu caagaagcac cccgagccgu ucuucgcccu ggccaaggag      300

cuguaccccg gccaguucaa gcccaccauc ugccacuacu ucaugcggcu gcugaaggac      360

aagggccucc ugcugcgcug cuacacccag aacaucgaca cgcucgagcg gaucgccggg      420

cuggagcagg aggaccuggu ggaggcgcac ggcaccuucu acaccuccca cugcgucagc      480

gccuccugcc gccacgagua cccccucagc uggaugaagg agaagaucuu cuccgaggug      540

accccgaagu gcgaggacug ccagagccug gugaagcccg acaucgucuu cuucggggag      600

ucccugcccg cccgguucuu cagcugcaug caguccgacu uccucaaggu ggaccugcug      660

cucgugaugg gcacgagccu gcagguccag cccuucgccu cccugaucag caaggcgccg      720

cucagcacgc cccgccugcu gaucaacaag gagaaggccg ggcaguccga ccccuuccuc      780

ggcaugauca ugggccucgg gggcgggaug gacuucgaca gcaagaaggc cuaccgggac      840

guggccuggc ugggcgagug cgaccagggc ugccuggccc uggcggagcu gcucgggugg      900

aagaaggagc uggaggaccu ggugcgccgg gagcacgccu ccaucgacgc ccagagcggc      960

gccggggucc ccaacccguc caccagcgcc ucccccaaga aguccccgcc gcccgcgaag     1020

gacgaggccc gcaccaccga gcgggagaag ccccaguga                            1059


<210>  3432
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SIRT2/m__Homo_sapiens__EAW56837

<400>  3432
auggacuucc uccgcaaccu cuucucccag acccucuccc ucggcuccca gaaggagcgc       60

cuccucgacg agcucacccu cgagggcguc gcccgcuaca ugcaguccga gcgcugccgc      120

cgcgucaucu gccucgucgg cgccggcauc uccaccuccg ccggcauccc cgacuuccgc      180

ucccccucca ccggccucua cgacaaccuc gagaaguacc accuccccua ccccgaggcc      240

aucuucgaga ucuccuacuu caagaagcac cccgagcccu ucuucgcccu cgccaaggag      300

cucuaccccg gccaguucaa gcccaccauc ugccacuacu ucaugcgccu ccucaaggac      360

aagggccucc uccuccgcug cuacacccag aacaucgaca cccucgagcg caucgccggc      420

cucgagcagg aggaccucgu cgaggcccac ggcaccuucu acaccuccca cugcgucucc      480

gccuccugcc gccacgagua cccccucucc uggaugaagg agaagaucuu cuccgagguc      540

acccccaagu gcgaggacug ccagucccuc gucaagcccg acaucgucuu cuucggcgag      600

ucccuccccg cccgcuucuu cuccugcaug caguccgacu uccucaaggu cgaccuccuc      660

cucgucaugg gcaccucccu ccagguccag cccuucgccu cccucaucuc caaggccccc      720

cucuccaccc cccgccuccu caucaacaag gagaaggccg gccaguccga ccccuuccuc      780

ggcaugauca ugggccucgg cggcggcaug gacuucgacu ccaagaaggc cuaccgcgac      840

gucgccuggc ucggcgagug cgaccagggc ugccucgccc ucgccgagcu ccucggcugg      900

aagaaggagc ucgaggaccu cguccgccgc gagcacgccu ccaucgacgc ccaguccggc      960

gccggcgucc ccaaccccuc caccuccgcc ucccccaaga aguccccccc ccccgccaag     1020

gacgaggccc gcaccaccga gcgcgagaag ccccaguga                            1059


<210>  3433
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SIRT2/m__Homo_sapiens__EAW56837

<400>  3433
auggacuucc ugagaaaccu cuuuagccag acccuuuccc ugggcucuca aaaggagagg       60

uuguuagaug aacugacacu agagggggug gcccgguaca ugcagucaga acgcugccga      120

cgugucaucu gucucguugg agcugguauu aguacuagcg caggcauacc cgacuucaga      180

uccccuucua cggggcugua ugauaaucuu gagaaauacc aucugccaua uccggaagcc      240

aucuuugaga uuucguacuu caagaaacac cccgagccau uuuucgcguu ggcuaaggaa      300

cucuauccug gacaguuuaa acccaccauc ugccacuacu ucaugaggcu gcugaaggac      360

aagggccucu uacugcggug uuauacacag aacauugaua cucuugagcg caucgccggu      420

uuggaacaag aggaccuggu ggaggcacau gggaccuuuu acacaucaca cugcguaagc      480

gccaguugua gacaugaaua cccucuaucc uggaugaaag agaagauauu cucugaagug      540

accccaaaau gcgaggauug ucagagccuc gucaagcccg acaucguguu uuucggagaa      600

ucccugccug cuagguuuuu cucaugcaug cagagugauu uccuuaaagu ugaccuguug      660

cucgugaugg gcacuagccu gcagguccaa ccauuugcau cuuuaauuuc caaggccccg      720

cugucaacac cccggcuccu uaucaauaag gagaaagcug gccagagcga uccuuuccug      780

gggaugauua ugggauuggg uggcgggaug gacuuugaua guaagaaagc cuaucgcgac      840

guggcguggc uaggagagug ugaccagggc ugccuggcac ucgccgaacu gcuugguugg      900

aagaaagagc uggaagauuu gguacgaaga gagcacgcuu cuaucgacgc ccaguccggg      960

gcaggaguuc caaaccccag caccucggcu ucuccuaaga aauccccacc cccggccaag     1020

gaugaagcga ggacgacuga gcgggagaag ccucaauga                            1059


<210>  3434
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SIRT2/m__Homo_sapiens__EAW56837

<400>  3434
auggacuucc ugagaaaccu guucagccag acccugagcc ugggcagcca gaaggagaga       60

cugcuggacg agcugacccu ggagggcgug gccagauaca ugcagagcga gagaugcaga      120

agagugaucu gccugguggg cgccggcauc agcaccagcg ccggcauccc cgacuucaga      180

agccccagca ccggccugua cgacaaccug gagaaguacc accugcccua ccccgaggcc      240

aucuucgaga ucagcuacuu caagaagcac cccgagcccu ucuucgcccu ggccaaggag      300

cuguaccccg gccaguucaa gcccaccauc ugccacuacu ucaugagacu gcugaaggac      360

aagggccugc ugcugagaug cuacacccag aacaucgaca cccuggagag aaucgccggc      420

cuggagcagg aggaccuggu ggaggcccac ggcaccuucu acaccagcca cugcgugagc      480

gccagcugca gacacgagua cccccugagc uggaugaagg agaagaucuu cagcgaggug      540

acccccaagu gcgaggacug ccagagccug gugaagcccg acaucguguu cuucggcgag      600

agccugcccg ccagauucuu cagcugcaug cagagcgacu uccugaaggu ggaccugcug      660

cuggugaugg gcaccagccu gcaggugcag cccuucgcca gccugaucag caaggccccc      720

cugagcaccc ccagacugcu gaucaacaag gagaaggccg gccagagcga ccccuuccug      780

ggcaugauca ugggccuggg cggcggcaug gacuucgaca gcaagaaggc cuacagagac      840

guggccuggc ugggcgagug cgaccagggc ugccuggccc uggccgagcu gcugggcugg      900

aagaaggagc uggaggaccu ggugagaaga gagcacgcca gcaucgacgc ccagagcggc      960

gccggcgugc ccaaccccag caccagcgcc agccccaaga agagcccccc ccccgccaag     1020

gacgaggcca gaaccaccga gagagagaag ccccaguga                            1059


<210>  3435
<211>  1059
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SIRT2/m__Homo_sapiens__EAW56837

<400>  3435
auggacuucc ugagaaaccu cuuuagccag acccuguccc uuggcucuca aaaggagcgg       60

cugcucgaug aacugacacu ugagggggug gcccgcuaca ugcagagcga aagaugccgg      120

cgcgucaucu gucugguugg agcuggcauu uccacgucug ccgggauccc cgacuucaga      180

agcccuucca ccggacucua ugauaaucug gagaaauacc aucugccgua ucccgaagcg      240

auuuuugaga ucucuuacuu caagaaacac ccugagcccu uuuucgcucu cgccaaggaa      300

cuguauccug gccaguuuaa acccacaauu ugccacuacu ucaugcggcu ucugaaggac      360

aaggggcucc ugcuucgcug uuauacccag aacaucgaua cacuggagag aaucgccgga      420

cucgaacaag aggaccuggu ggaggcucau ggcaccuuuu acacaagcca cugcgugucc      480

gccagcuguc ggcaugaaua cccucugucu uggaugaaag agaagauuuu cuccgaaguc      540

accccgaaau gcgaggauug ucagagccuc gugaagcccg acaucguguu uuucggcgaa      600

ucucugccug cucgcuuuuu cuccugcaug cagagcgauu uccuuaaagu ugaccugcuc      660

cuggucaugg ggacgucucu ucaggugcaa cccuuugccu cccugauuag caaggcgccu      720

cucuccaccc ccagacugcu gaucaauaag gagaaagccg gacagucuga uccguuccuc      780

ggcaugauua uggggcuggg aggcgggaug gacuuugaua gcaagaaagc cuaucgggac      840

guugcuuggc uuggagagug ugaccagggc ugccuggcuc ucgccgaacu gcuuggcugg      900

aagaaagagc uggaagaucu cgugcgcaga gagcacgcgu ccaucgacgc ccagagcggg      960

gcuggagucc cuaaccccuc uacauccgcc agcccuaaga aaucuccccc ucccgcuaag     1020

gaugaagccc ggaccacaga gcgcgagaag ccgcaauga                            1059


<210>  3436
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SIRT2/m__Homo_sapiens__Q8IXJ6

<400>  3436

Met Ala Glu Pro Asp Pro Ser His Pro Leu Glu Thr Gln Ala Gly Lys 
1               5                   10                  15      


Val Gln Glu Ala Gln Asp Ser Asp Ser Asp Ser Glu Gly Gly Ala Ala 
            20                  25                  30          


Gly Gly Glu Ala Asp Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr 
        35                  40                  45              


Leu Ser Leu Gly Ser Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu 
    50                  55                  60                  


Glu Gly Val Ala Arg Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile 
65                  70                  75                  80  


Cys Leu Val Gly Ala Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe 
                85                  90                  95      


Arg Ser Pro Ser Thr Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu 
            100                 105                 110         


Pro Tyr Pro Glu Ala Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro 
        115                 120                 125             


Glu Pro Phe Phe Ala Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys 
    130                 135                 140                 


Pro Thr Ile Cys His Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu 
145                 150                 155                 160 


Leu Leu Arg Cys Tyr Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala 
                165                 170                 175     


Gly Leu Glu Gln Glu Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr 
            180                 185                 190         


Ser His Cys Val Ser Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp 
        195                 200                 205             


Met Lys Glu Lys Ile Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys 
    210                 215                 220                 


Gln Ser Leu Val Lys Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro 
225                 230                 235                 240 


Ala Arg Phe Phe Ser Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu 
                245                 250                 255     


Leu Leu Val Met Gly Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu 
            260                 265                 270         


Ile Ser Lys Ala Pro Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu 
        275                 280                 285             


Lys Ala Gly Gln Ser Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly 
    290                 295                 300                 


Gly Gly Met Asp Phe Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp 
305                 310                 315                 320 


Leu Gly Glu Cys Asp Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly 
                325                 330                 335     


Trp Lys Lys Glu Leu Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile 
            340                 345                 350         


Asp Ala Gln Ser Gly Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser 
        355                 360                 365             


Pro Lys Lys Ser Pro Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu 
    370                 375                 380                 


Arg Glu Lys Pro Gln 
385                 


<210>  3437
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SIRT2/m__Homo_sapiens__AAD40850

<400>  3437
auggcagagc cagaccccuc ucacccucug gagacccagg cagggaaggu gcaggaggcu       60

caggacucag auucagacuc ugagggagga gccgcuggug gagaagcaga cauggacuuc      120

cugcggaacu uauucuccca gacgcucagc cugggcagcc agaaggagcg ucugcuggac      180

gagcugaccu uggaaggggu ggcccgguac augcagagcg aacgcugucg cagagucauc      240

uguuuggugg gagcuggaau cuccacaucc gcaggcaucc ccgacuuucg cucuccaucc      300

accggccucu augacaaccu agagaaguac caucuucccu acccagaggc caucuuugag      360

aucagcuauu ucaagaaaca uccggaaccc uucuucgccc ucgccaagga acucuauccu      420

gggcaguuca agccaaccau cugucacuac uucaugcgcc ugcugaagga caaggggcua      480

cuccugcgcu gcuacacgca gaacauagau acccuggagc gaauagccgg gcuggaacag      540

gaggacuugg uggaggcgca cggcaccuuc uacacaucac acugcgucag cgccagcugc      600

cggcacgaau acccgcuaag cuggaugaaa gagaagaucu ucucugaggu gacgcccaag      660

ugugaagacu gucagagccu ggugaagccu gauaucgucu uuuuugguga gagccuccca      720

gcgcguuucu ucuccuguau gcagucagac uuccugaagg uggaccuccu ccuggucaug      780

gguaccuccu ugcaggugca gcccuuugcc ucccucauca gcaaggcacc ccucuccacc      840

ccucgccugc ucaucaacaa ggagaaagcu ggccagucgg acccuuuccu ggggaugauu      900

augggccucg gaggaggcau ggacuuugac uccaagaagg ccuacaggga cguggccugg      960

cugggugaau gcgaccaggg cugccuggcc cuugcugagc uccuuggaug gaagaaggag     1020

cuggaggacc uuguccggag ggagcacgcc agcauagaug cccagucggg ggcggggguc     1080

cccaacccca gcacuucagc uucccccaag aaguccccgc caccugccaa ggacgaggcc     1140

aggacaacag agagggagaa accccaguga                                      1170


<210>  3438
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SIRT2/m__Homo_sapiens__AAD40850

<400>  3438
auggccgagc ccgaccccag ccacccccug gagacccagg ccggcaaggu gcaggaggcg       60

caggacagcg acagcgacuc cgagggcggg gccgccgggg gcgaggccga cauggacuuc      120

cuccgcaacc uguucagcca gacccugucc cucgggagcc agaaggagcg gcugcuggac      180

gagcucacgc uggagggcgu cgcccgcuac augcaguccg agcggugccg ccgggugauc      240

ugccuggugg gcgcggggau cagcaccucc gccggcaucc ccgacuuccg cagccccucc      300

accgggcucu acgacaaccu ggagaaguac caccucccgu accccgaggc caucuucgag      360

aucagcuacu ucaagaagca ccccgagccc uucuucgccc uggcgaagga gcuguacccg      420

ggccaguuca agcccaccau cugccacuac uucaugcggc ugcucaagga caaggggcug      480

cugcuccgcu gcuacacgca gaacaucgac acccuggagc ggaucgccgg ccuggagcag      540

gaggaccucg ucgaggccca cggcaccuuc uacaccuccc acugcgugag cgccuccugc      600

cgccacgagu acccccugag cuggaugaag gagaagaucu ucuccgaggu gacgcccaag      660

ugcgaggacu gccagagccu ggucaagccg gacaucgugu ucuucgggga gucccucccc      720

gcccgguucu ucagcugcau gcagagcgac uuccugaagg uggaccugcu ccuggucaug      780

ggcaccuccc uccaggugca gcccuucgcg agccugaucu ccaaggcgcc ccugagcacc      840

ccgcgccugc ucaucaacaa ggagaaggcc gggcaguccg accccuuccu gggcaugauc      900

augggccucg ggggcgggau ggacuucgac agcaagaagg ccuaccggga cguggccugg      960

cugggcgagu gcgaccaggg gugccuggcc cuggccgagc uccugggcug gaagaaggag     1020

cuggaggacc ucguccgccg ggagcacgcc uccaucgacg cccagagcgg cgccggggug     1080

cccaaccccu ccaccagcgc guccccgaag aaguccccgc cgcccgccaa ggacgaggcc     1140

cgcacgaccg agcgggagaa gccccaguga                                      1170


<210>  3439
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SIRT2/m__Homo_sapiens__AAD40850

<400>  3439
auggccgagc ccgaccccuc ccacccccuc gagacccagg ccggcaaggu ccaggaggcc       60

caggacuccg acuccgacuc cgagggcggc gccgccggcg gcgaggccga cauggacuuc      120

cuccgcaacc ucuucuccca gacccucucc cucggcuccc agaaggagcg ccuccucgac      180

gagcucaccc ucgagggcgu cgcccgcuac augcaguccg agcgcugccg ccgcgucauc      240

ugccucgucg gcgccggcau cuccaccucc gccggcaucc ccgacuuccg cucccccucc      300

accggccucu acgacaaccu cgagaaguac caccuccccu accccgaggc caucuucgag      360

aucuccuacu ucaagaagca ccccgagccc uucuucgccc ucgccaagga gcucuacccc      420

ggccaguuca agcccaccau cugccacuac uucaugcgcc uccucaagga caagggccuc      480

cuccuccgcu gcuacaccca gaacaucgac acccucgagc gcaucgccgg ccucgagcag      540

gaggaccucg ucgaggccca cggcaccuuc uacaccuccc acugcgucuc cgccuccugc      600

cgccacgagu acccccucuc cuggaugaag gagaagaucu ucuccgaggu cacccccaag      660

ugcgaggacu gccagucccu cgucaagccc gacaucgucu ucuucggcga gucccucccc      720

gcccgcuucu ucuccugcau gcaguccgac uuccucaagg ucgaccuccu ccucgucaug      780

ggcaccuccc uccaggucca gcccuucgcc ucccucaucu ccaaggcccc ccucuccacc      840

ccccgccucc ucaucaacaa ggagaaggcc ggccaguccg accccuuccu cggcaugauc      900

augggccucg gcggcggcau ggacuucgac uccaagaagg ccuaccgcga cgucgccugg      960

cucggcgagu gcgaccaggg cugccucgcc cucgccgagc uccucggcug gaagaaggag     1020

cucgaggacc ucguccgccg cgagcacgcc uccaucgacg cccaguccgg cgccggcguc     1080

cccaaccccu ccaccuccgc cucccccaag aagucccccc cccccgccaa ggacgaggcc     1140

cgcaccaccg agcgcgagaa gccccaguga                                      1170


<210>  3440
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SIRT2/m__Homo_sapiens__AAD40850

<400>  3440
auggccgagc ccgacccuag ccacccacug gaaacccagg cuggcaaggu gcaagaggca       60

caggauuccg acucugauuc agaaggggga gccgcgggug gcgaggcuga cauggauuuc      120

cucagaaacc uuuuuaguca gacacugagc uugggguccc agaaagaaag guuacuggac      180

gagcuaacuc ucgagggagu cgcccgguac augcaaucug aacgcugccg acguguuauc      240

ugucuggugg gcgcagguau uucgacguca gccgggauac cggauuucag aagccccagu      300

accggacuuu augacaaucu ggagaaguac cauuugccuu auccagaagc uaucuuugag      360

auuuccuacu ucaaaaagca ccccgagcca uuuuucgcac ucgccaaaga acuguauccu      420

ggccaguuua agcccacaau cugccauuac uucaugaggc ugcucaagga uaaaggcuua      480

cugcuucggu guuauacuca gaacauugac accuuggagc gcaucgcugg gcuggaacag      540

gaggaucuag uagaagccca cggaacauuu uacaccucuc auugcgugag cgcguccugu      600

agacacgagu acccucucuc auggaugaag gagaaaauau ucagugaagu cacuccaaag      660

ugcgaggacu gucaaagccu ggugaaaccg gauaucgugu uuuucgguga aucucuuccc      720

gcaagguuuu ucuccugcau gcagucagac uuccugaagg uugacuugcu ccuggucaug      780

ggcaccagcu uacaggugca gccuuuugcc agucugauuu cuaaggcucc acucuccaca      840

ccccggcuuc ugaucaauaa agagaaggcc gggcaaagcg auccuuucuu gggaaugauu      900

augggccuag gugggggaau ggacuuugau ucgaaaaagg cauaucgcga cguagcuugg      960

cugggcgaau gugaucaggg cugccucgcc cuggcggagc uucuggggug gaaaaaggag     1020

uuggaagacc ucguucgaag agagcacgcc ucuaucgaug cacaguccgg agcuggugug     1080

ccaaaccccu caacgagugc cagcccgaaa aaguccccuc ccccagcuaa ggacgaagcc     1140

aggacuaccg agcgggaaaa accucaauga                                      1170


<210>  3441
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SIRT2/m__Homo_sapiens__AAD40850

<400>  3441
auggccgagc ccgaccccag ccacccccug gagacccagg ccggcaaggu gcaggaggcc       60

caggacagcg acagcgacag cgagggcggc gccgccggcg gcgaggccga cauggacuuc      120

cugagaaacc uguucagcca gacccugagc cugggcagcc agaaggagag acugcuggac      180

gagcugaccc uggagggcgu ggccagauac augcagagcg agagaugcag aagagugauc      240

ugccuggugg gcgccggcau cagcaccagc gccggcaucc ccgacuucag aagccccagc      300

accggccugu acgacaaccu ggagaaguac caccugcccu accccgaggc caucuucgag      360

aucagcuacu ucaagaagca ccccgagccc uucuucgccc uggccaagga gcuguacccc      420

ggccaguuca agcccaccau cugccacuac uucaugagac ugcugaagga caagggccug      480

cugcugagau gcuacaccca gaacaucgac acccuggaga gaaucgccgg ccuggagcag      540

gaggaccugg uggaggccca cggcaccuuc uacaccagcc acugcgugag cgccagcugc      600

agacacgagu acccccugag cuggaugaag gagaagaucu ucagcgaggu gacccccaag      660

ugcgaggacu gccagagccu ggugaagccc gacaucgugu ucuucggcga gagccugccc      720

gccagauucu ucagcugcau gcagagcgac uuccugaagg uggaccugcu gcuggugaug      780

ggcaccagcc ugcaggugca gcccuucgcc agccugauca gcaaggcccc ccugagcacc      840

cccagacugc ugaucaacaa ggagaaggcc ggccagagcg accccuuccu gggcaugauc      900

augggccugg gcggcggcau ggacuucgac agcaagaagg ccuacagaga cguggccugg      960

cugggcgagu gcgaccaggg cugccuggcc cuggccgagc ugcugggcug gaagaaggag     1020

cuggaggacc uggugagaag agagcacgcc agcaucgacg cccagagcgg cgccggcgug     1080

cccaacccca gcaccagcgc cagccccaag aagagccccc cccccgccaa ggacgaggcc     1140

agaaccaccg agagagagaa gccccaguga                                      1170


<210>  3442
<211>  1170
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SIRT2/m__Homo_sapiens__AAD40850

<400>  3442
auggccgagc ccgacccuag ccacccgcug gaaacccagg cuggcaaggu gcaagaggcc       60

caggauuccg acucugauag cgaaggggga gcggcuggcg gggaggccga cauggauuuc      120

cucagaaacc uguuuuccca gacacuuucu cugggaagcc agaaagaacg gcuccuggac      180

gagcuuacgc uggagggcgu cgcccgcuac augcaauccg aaagaugccg gcgcguuauc      240

ugucucgugg gggcuggaau uucuaccagc gccggcaucc ccgauuucag auccccuagc      300

acaggccugu augacaaucu ggagaaguac caucuccccu auccugaagc uauuuuugag      360

aucucuuacu ucaaaaagca ccccgagccg uuuuucgccc uggcgaaaga acuuuauccu      420

gggcaguuua agcccaccau uugccauuac uucaugcggc ugcucaagga uaaaggacug      480

cuucugcgcu guuauacaca gaacaucgac acccucgaga gaaucgccgg ccuggaacag      540

gaggaucugg uggaagcuca cgggacauuu uacaccuccc auugcgucag cgccucuugu      600

cggcacgagu acccucucuc cuggaugaag gagaaaauuu ucagcgaagu gacgcccaag      660

ugcgaggacu gucaaucucu gguuaaaccu gauaucgugu uuuucggaga aucccuuccc      720

gcucgcuuuu ucagcugcau gcaguccgac uuccugaagg ucgaccuccu gcuugugaug      780

ggcaccucuc ugcagguuca gccguuugcc agccucauuu ccaaggcgcc ucugagcaca      840

cccagacugc ucaucaauaa agagaaggcc gggcaaucug auccuuuccu gggaaugauu      900

augggccuug gcgggggaau ggacuuugau uccaaaaagg cuuaucggga cguggccugg      960

cugggcgaau gugaucaggg gugccucgcu cuggccgagc uucugggaug gaaaaaggag     1020

cucgaagacc ugguccgcag agagcacgcc agcaucgaug cucagucugg cgcgggggug     1080

cccaacccca gcaccuccgc cucuccuaaa aagagcccgc ccccugcuaa ggacgaagcc     1140

cggacaaccg agcgcgaaaa accccaauga                                      1170


<210>  3443
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SOX10__Homo_sapiens__P56693

<400>  3443

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  3444
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SOX10__Homo_sapiens__AAH02824

<400>  3444
auggcggagg agcaggaccu aucggaggug gagcugagcc ccgugggcuc ggaggagccc       60

cgcugccugu ccccggggag cgcgcccucg cuagggcccg acggcggcgg cggcggaucg      120

ggccugcgag ccagcccggg gccaggcgag cugggcaagg ucaagaagga gcagcaggac      180

ggcgaggcgg acgaugacaa guuccccgug ugcauccgcg aggccgucag ccaggugcuc      240

agcggcuacg acuggacgcu ggugcccaug cccgugcgcg ucaacggcgc cagcaaaagc      300

aagccgcacg ucaagcggcc caugaacgcc uucauggugu gggcucaggc agcgcgcagg      360

aagcucgcgg accaguaccc gcaccugcac aacgcugagc ucagcaagac gcugggcaag      420

cucuggaggc ugcugaacga aagugacaag cgccccuuca ucgaggaggc ugagcggcuc      480

cguaugcagc acaagaaaga ccacccggac uacaaguacc agcccaggcg gcggaagaac      540

gggaaggccg cccagggcga ggcggagugc cccggugggg aggccgagca aggugggacc      600

gccgccaucc aggcccacua caagagcgcc cacuuggacc accggcaccc aggagagggc      660

ucccccaugu cagaugggaa ccccgagcac cccucaggcc agagccaugg cccacccacc      720

ccuccaacca ccccgaagac agagcugcag ucgggcaagg cagacccgaa gcgggacggg      780

cgcuccaugg gggagggcgg gaagccucac aucgacuucg gcaacgugga cauuggugag      840

aucagccacg agguaauguc caacauggag accuuugaug uggcugaguu ggaccaguac      900

cugccgccca augggcaccc aggccaugug agcagcuacu cagcagccgg cuaugggcug      960

ggcagugccc uggccguggc caguggacac uccgccugga ucuccaagcc accaggcgug     1020

gcucugccca cggucucacc accuggugug gaugccaaag cccaggugaa gacagagacc     1080

gcggggcccc aggggccccc acacuacacc gaccagccau ccaccucaca gaucgccuac     1140

accucccuca gccugcccca cuauggcuca gccuuccccu ccaucucccg cccccaguuu     1200

gacuacucug accaucagcc cucaggaccc uauuauggcc acucgggcca ggccucuggc     1260

cucuacucgg ccuucuccua uauggggccc ucgcagcggc cccucuacac ggccaucucu     1320

gaccccagcc ccucagggcc ccagucccac agccccacac acugggagca gccaguauau     1380

acgacacugu cccggcccua a                                               1401


<210>  3445
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SOX10__Homo_sapiens__AAH02824

<400>  3445
auggccgagg agcaggaccu gagcgaggug gagcucuccc ccgucggcag cgaggagccg       60

cgcugccugu cccccgggag cgcccccucc cugggccccg acgggggcgg gggcggcagc      120

gggcuccggg cguccccggg ccccggggag cugggcaagg ugaagaagga gcagcaggac      180

ggggaggccg acgacgacaa guuccccgug ugcauccgcg aggccgucag ccaggugcug      240

uccggcuacg acuggacccu cgugcccaug ccgguccggg ugaacggcgc cagcaagucc      300

aagccccacg ugaagcgccc caugaacgcc uucauggucu gggcgcaggc cgcccggcgc      360

aagcuggccg accaguaccc ccaccuccac aacgcggagc ucagcaagac ccuggggaag      420

cuguggcggc uccugaacga guccgacaag cgcccguuca ucgaggaggc cgagcggcug      480

cgcaugcagc acaagaagga ccaccccgac uacaaguacc agccccggcg ccggaagaac      540

ggcaaggccg cccaggggga ggccgagugc cccggcggcg aggcggagca gggcgggacg      600

gccgccaucc aggcccacua caagagcgcc caccucgacc accgccaccc gggggagggc      660

ucccccauga gcgacgggaa ccccgagcac cccuccggcc agagccacgg cccgcccacc      720

ccgcccacca cccccaagac ggagcugcag uccgggaagg cggaccccaa gcgggacggc      780

cgcagcaugg gggagggcgg gaagccccac aucgacuucg gcaacgugga caucggcgag      840

aucagccacg aggugauguc caacauggag accuucgacg ucgccgagcu ggaccaguac      900

cugcccccga acgggcaccc cggccacgug agcuccuaca gcgccgccgg guacggccug      960

ggguccgccc uggcgguggc cagcggccac uccgccugga ucagcaagcc cccgggcguc     1020

gcccucccca ccgugucccc gcccggggug gacgccaagg cgcaggucaa gaccgagacg     1080

gccggccccc aggggccgcc ccacuacacc gaccagccca gcaccuccca gaucgccuac     1140

accagccugu cccugcccca cuacggcagc gccuuccccu ccaucagccg gccccaguuc     1200

gacuacuccg accaccagcc cagcggcccg uacuacgggc acuccggcca ggcgagcggg     1260

cucuacagcg ccuucuccua caugggcccc agccagcgcc cccuguacac ggccaucucc     1320

gaccccagcc cguccgggcc ccagagccac ucccccaccc acugggagca gcccguguac     1380

accacccuga gccggccgug a                                               1401


<210>  3446
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SOX10__Homo_sapiens__AAH02824

<400>  3446
auggccgagg agcaggaccu cuccgagguc gagcucuccc ccgucggcuc cgaggagccc       60

cgcugccucu cccccggcuc cgcccccucc cucggccccg acggcggcgg cggcggcucc      120

ggccuccgcg ccucccccgg ccccggcgag cucggcaagg ucaagaagga gcagcaggac      180

ggcgaggccg acgacgacaa guuccccguc ugcauccgcg aggccgucuc ccagguccuc      240

uccggcuacg acuggacccu cguccccaug cccguccgcg ucaacggcgc cuccaagucc      300

aagccccacg ucaagcgccc caugaacgcc uucauggucu gggcccaggc cgcccgccgc      360

aagcucgccg accaguaccc ccaccuccac aacgccgagc ucuccaagac ccucggcaag      420

cucuggcgcc uccucaacga guccgacaag cgccccuuca ucgaggaggc cgagcgccuc      480

cgcaugcagc acaagaagga ccaccccgac uacaaguacc agccccgccg ccgcaagaac      540

ggcaaggccg cccagggcga ggccgagugc cccggcggcg aggccgagca gggcggcacc      600

gccgccaucc aggcccacua caaguccgcc caccucgacc accgccaccc cggcgagggc      660

ucccccaugu ccgacggcaa ccccgagcac cccuccggcc agucccacgg cccccccacc      720

ccccccacca cccccaagac cgagcuccag uccggcaagg ccgaccccaa gcgcgacggc      780

cgcuccaugg gcgagggcgg caagccccac aucgacuucg gcaacgucga caucggcgag      840

aucucccacg aggucauguc caacauggag accuucgacg ucgccgagcu cgaccaguac      900

cuccccccca acggccaccc cggccacguc uccuccuacu ccgccgccgg cuacggccuc      960

ggcuccgccc ucgccgucgc cuccggccac uccgccugga ucuccaagcc ccccggcguc     1020

gcccucccca ccgucucccc ccccggcguc gacgccaagg cccaggucaa gaccgagacc     1080

gccggccccc agggcccccc ccacuacacc gaccagcccu ccaccuccca gaucgccuac     1140

accucccucu cccuccccca cuacggcucc gccuuccccu ccaucucccg cccccaguuc     1200

gacuacuccg accaccagcc cuccggcccc uacuacggcc acuccggcca ggccuccggc     1260

cucuacuccg ccuucuccua caugggcccc ucccagcgcc cccucuacac cgccaucucc     1320

gaccccuccc ccuccggccc ccagucccac ucccccaccc acugggagca gcccgucuac     1380

accacccucu cccgccccug a                                               1401


<210>  3447
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SOX10__Homo_sapiens__AAH02824

<400>  3447
auggccgagg aacaggaccu gagcgaggug gaacucuccc ccgucggcuc ugaggaaccu       60

agaugccuuu caccagggag ugcuccgagc cugggacccg augguggcgg gggaggcucc      120

gguuugaggg caucuccugg gccaggagag uuaggcaagg uuaaaaagga gcaacaggac      180

ggcgaagccg augacgauaa auuccccgug uguauccggg aggcgguauc gcaagugcug      240

ucaggguacg acuggacccu agucccuaug ccagugcgcg uuaacggagc uagcaagagu      300

aaaccccacg ugaagcgacc uaugaaugcc uuuauggucu gggcacaggc cgcucguaga      360

aagcucgcag aucaauaucc acaucugcac aacgccgaac uuuccaaaac acuggguaag      420

uuguggaggc uccugaauga gucugacaaa cggccguuca uugaggaagc ugagcgccug      480

agaaugcagc auaagaaaga ucaccccgac uacaaguauc agccuaggcg gcgcaagaac      540

ggcaaagccg cgcaggggga agcagagugc ccaggaggcg aagccgagca aggugggacu      600

gcugccauac aggcacauua caagagcgcu caccucgauc accgacaucc cggagagggc      660

uccccuaugu cagacggcaa uccagaacac cccagugggc agagccaugg accgccuacg      720

cccccaacca caccuaaaac ugaguuacag ucugguaagg ccgaucccaa aagagacggc      780

agguccaugg gggaaggagg caagccacac aucgacuuug guaacgugga uauuggggag      840

aucucacacg aaguaaugag caauauggag accuucgacg uugcggagcu ggaucaauau      900

cuucccccua acggccaucc aggacacgug aguucuuacu ccgccgcagg cuauggguug      960

ggaagcgcuc uggccgucgc uucgggucau ucugccugga uuuccaaacc gcccggcgug     1020

gcacuaccua cagugucacc acccgggguc gacgccaagg cucagguuaa gaccgaaacu     1080

gcgggaccuc agggcccacc ccacuacaca gaucaaccga guaccagcca gaucgcauac     1140

acgucccucu cucugccuca uuaugguagc gccuuuccau caauaagucg gccccaguuc     1200

gacuacuccg aucaccagcc uagcgggccc uauuacggcc acucuggaca ggcuucaggc     1260

cuuuauagug ccuuuagcua cauggggcca ucccagcguc cucuguauac ugcaaucucu     1320

gaccccucgc caagcggacc gcagucccau ucaccuaccc acugggagca gcccguguac     1380

acaacuuuga gucgcccaug a                                               1401


<210>  3448
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SOX10__Homo_sapiens__AAH02824

<400>  3448
auggccgagg agcaggaccu gagcgaggug gagcugagcc ccgugggcag cgaggagccc       60

agaugccuga gccccggcag cgcccccagc cugggccccg acggcggcgg cggcggcagc      120

ggccugagag ccagccccgg ccccggcgag cugggcaagg ugaagaagga gcagcaggac      180

ggcgaggccg acgacgacaa guuccccgug ugcaucagag aggccgugag ccaggugcug      240

agcggcuacg acuggacccu ggugcccaug cccgugagag ugaacggcgc cagcaagagc      300

aagccccacg ugaagagacc caugaacgcc uucauggugu gggcccaggc cgccagaaga      360

aagcuggccg accaguaccc ccaccugcac aacgccgagc ugagcaagac ccugggcaag      420

cuguggagac ugcugaacga gagcgacaag agacccuuca ucgaggaggc cgagagacug      480

agaaugcagc acaagaagga ccaccccgac uacaaguacc agcccagaag aagaaagaac      540

ggcaaggccg cccagggcga ggccgagugc cccggcggcg aggccgagca gggcggcacc      600

gccgccaucc aggcccacua caagagcgcc caccuggacc acagacaccc cggcgagggc      660

agccccauga gcgacggcaa ccccgagcac cccagcggcc agagccacgg cccccccacc      720

ccccccacca cccccaagac cgagcugcag agcggcaagg ccgaccccaa gagagacggc      780

agaagcaugg gcgagggcgg caagccccac aucgacuucg gcaacgugga caucggcgag      840

aucagccacg aggugaugag caacauggag accuucgacg uggccgagcu ggaccaguac      900

cugcccccca acggccaccc cggccacgug agcagcuaca gcgccgccgg cuacggccug      960

ggcagcgccc uggccguggc cagcggccac agcgccugga ucagcaagcc ccccggcgug     1020

gcccugccca ccgugagccc ccccggcgug gacgccaagg cccaggugaa gaccgagacc     1080

gccggccccc agggcccccc ccacuacacc gaccagccca gcaccagcca gaucgccuac     1140

accagccuga gccugcccca cuacggcagc gccuucccca gcaucagcag accccaguuc     1200

gacuacagcg accaccagcc cagcggcccc uacuacggcc acagcggcca ggccagcggc     1260

cuguacagcg ccuucagcua caugggcccc agccagagac cccuguacac cgccaucagc     1320

gaccccagcc ccagcggccc ccagagccac agccccaccc acugggagca gcccguguac     1380

accacccuga gcagacccug a                                               1401


<210>  3449
<211>  1401
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SOX10__Homo_sapiens__AAH02824

<400>  3449
auggccgagg aacaggaccu gagcgaggug gaacucuccc ccgucggcuc ugaggaaccu       60

agaugccuga gcccgggguc cgcucccucu cuuggaccug auggcggggg aggcgggagc      120

ggacugcggg ccucccccgg cccuggcgag cucgggaagg uuaaaaagga gcaacaggac      180

ggagaagcgg augacgauaa auuccccgug uguauccgcg aggcuguguc ucagguccug      240

agcggcuacg acuggacccu ugugccuaug ccgguuagag ugaacggggc cuccaagagc      300

aaaccccacg ucaagcggcc uaugaaugcc uuuauggugu gggcucaggc cgcucgcaga      360

aagcuggccg aucaauaucc ccaucuccac aacgcggaac ugucuaaaac acugggaaag      420

cucuggcggc ugcuuaauga guccgacaaa cgcccuuuca uugaggaagc cgagagacug      480

cggaugcagc auaagaaaga ucaccccgac uacaaguauc agccgcgcag acggaagaac      540

ggcaaagcug cccaggggga agcugagugc ccuggaggcg aagccgagca aggcgggacg      600

gcggccaucc aggcucauua caagagcgcc caccucgauc accgccaucc cggagagggc      660

ucuccuaugu ccgacgggaa ucccgaacac cccagcggac agucucaugg cccuccgaca      720

cccccuacca cccccaaaac agagcugcag uccgggaagg cugauccuaa aagagacgga      780

cggagcaugg gcgaaggcgg gaagccccac auugacuuug gaaacguuga uaucggcgag      840

auuucccacg aagugauguc uaauauggag accuucgacg ucgccgagcu ugaucaauau      900

cugccgccua acgggcaucc cggacacgug agcuccuaca gcgccgcugg cuaugggcuc      960

ggcucugcgc uggccguggc uuccggacau agcgccugga ucucuaaacc ucccggcguc     1020

gcccugccua caguuagccc gcccggggug gacgcuaagg cccaggugaa gaccgaaacg     1080

gcgggaccuc agggcccucc ccacuacacc gaucaacccu ccacaucuca gaucgcuuac     1140

accagccucu cccugccgca uuaugggagc gccuuucccu cuauuucccg cccucaguuc     1200

gacuacagcg aucaccagcc cucuggaccu uauuacggcc acuccgggca agccagcggc     1260

cuuuauuccg cuuuuucuua caugggaccc agccagagac cucuguauac agccaucucc     1320

gaccccucuc cgagcggccc ucagucccau agccccaccc acugggagca gccugucuac     1380

acgacacucu cucggcccug a                                               1401


<210>  3450
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SP17__Homo_sapiens__Q15506

<400>  3450

Met Ser Ile Pro Phe Ser Asn Thr His Tyr Arg Ile Pro Gln Gly Phe 
1               5                   10                  15      


Gly Asn Leu Leu Glu Gly Leu Thr Arg Glu Ile Leu Arg Glu Gln Pro 
            20                  25                  30          


Asp Asn Ile Pro Ala Phe Ala Ala Ala Tyr Phe Glu Ser Leu Leu Glu 
        35                  40                  45              


Lys Arg Glu Lys Thr Asn Phe Asp Pro Ala Glu Trp Gly Ser Lys Val 
    50                  55                  60                  


Glu Asp Arg Phe Tyr Asn Asn His Ala Phe Glu Glu Gln Glu Pro Pro 
65                  70                  75                  80  


Glu Lys Ser Asp Pro Lys Gln Glu Glu Ser Gln Ile Ser Gly Lys Glu 
                85                  90                  95      


Glu Glu Thr Ser Val Thr Ile Leu Asp Ser Ser Glu Glu Asp Lys Glu 
            100                 105                 110         


Lys Glu Glu Val Ala Ala Val Lys Ile Gln Ala Ala Phe Arg Gly His 
        115                 120                 125             


Ile Ala Arg Glu Glu Ala Lys Lys Met Lys Thr Asn Ser Leu Gln Asn 
    130                 135                 140                 


Glu Glu Lys Glu Glu Asn Lys 
145                 150     


<210>  3451
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SP17__Homo_sapiens__AAH32457

<400>  3451
augucgauuc cauucuccaa cacccacuac cgaauuccac aaggauuugg gaaucuucuu       60

gaagggcuga cacgcgagau ucugagagag caaccggaca auauaccagc uuuugcagca      120

gccuauuuug agagccuucu agagaaaaga gagaaaacca acuuugaucc agcagaaugg      180

gggaguaagg uagaagaccg cuucuauaac aaucaugcau ucgaggagca agaaccaccu      240

gagaaaagug auccuaaaca agaagagucu cagauaucug ggaaggagga agagacauca      300

gucaccaucu uagacucuuc ugaggaagau aaggaaaaag aagagguugc ugcugucaaa      360

auccaagcug ccuuccgggg acacauagcc agagaggagg caaagaaaau gaaaacaaau      420

agucuucaaa augaggaaaa agaggaaaac aaguga                                456


<210>  3452
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SP17__Homo_sapiens__AAH32457

<400>  3452
augagcaucc ccuucuccaa cacccacuac cgcaucccgc agggcuucgg gaaccugcuc       60

gagggccuga cccgggagau ccugcgcgag cagcccgaca acauccccgc cuucgccgcg      120

gccuacuucg agagccuccu ggagaagcgg gagaagacga acuucgaccc cgccgagugg      180

ggguccaagg uggaggaccg cuucuacaac aaccacgccu ucgaggagca ggagccgccc      240

gagaaguccg accccaagca ggaggagagc cagaucagcg gcaaggagga ggagaccucc      300

gucaccaucc uggacagcuc cgaggaggac aaggagaagg aggagguggc cgcggugaag      360

auccaggccg ccuuccgggg gcacaucgcc cgcgaggagg cgaagaagau gaagaccaac      420

agccuccaga acgaggagaa ggaggagaac aaguga                                456


<210>  3453
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SP17__Homo_sapiens__AAH32457

<400>  3453
auguccaucc ccuucuccaa cacccacuac cgcauccccc agggcuucgg caaccuccuc       60

gagggccuca cccgcgagau ccuccgcgag cagcccgaca acauccccgc cuucgccgcc      120

gccuacuucg agucccuccu cgagaagcgc gagaagacca acuucgaccc cgccgagugg      180

ggcuccaagg ucgaggaccg cuucuacaac aaccacgccu ucgaggagca ggagcccccc      240

gagaaguccg accccaagca ggaggagucc cagaucuccg gcaaggagga ggagaccucc      300

gucaccaucc ucgacuccuc cgaggaggac aaggagaagg aggaggucgc cgccgucaag      360

auccaggccg ccuuccgcgg ccacaucgcc cgcgaggagg ccaagaagau gaagaccaac      420

ucccuccaga acgaggagaa ggaggagaac aaguga                                456


<210>  3454
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SP17__Homo_sapiens__AAH32457

<400>  3454
augagcaucc ccuucuccaa cacccacuac aggauuccuc agggcuuugg gaaucugcuc       60

gagggacuua caagagaaau acugcgggag caaccagaca acaucccggc cuucgcugca      120

gccuauuuug aaucuuuguu agagaagcgc gagaaaacua auuucgaucc cgcggagugg      180

gguucaaagg uggaggaccg auuuuacaac aaucaugcuu ucgaagaaca ggaaccucca      240

gagaaaagug aucccaagca ggaggaaagc cagauuuccg gcaaagagga agagacgucu      300

gucaccaucc uggacucguc agaagaggau aaggagaagg aagagguugc cgcagugaaa      360

auucaagccg cuuuucgugg gcacaucgca agagaagagg ccaagaaaau gaagacaaac      420

agccuacaga augaagagaa agaggaaaac aaguga                                456


<210>  3455
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SP17__Homo_sapiens__AAH32457

<400>  3455
augagcaucc ccuucagcaa cacccacuac agaauccccc agggcuucgg caaccugcug       60

gagggccuga ccagagagau ccugagagag cagcccgaca acauccccgc cuucgccgcc      120

gccuacuucg agagccugcu ggagaagaga gagaagacca acuucgaccc cgccgagugg      180

ggcagcaagg uggaggacag auucuacaac aaccacgccu ucgaggagca ggagcccccc      240

gagaagagcg accccaagca ggaggagagc cagaucagcg gcaaggagga ggagaccagc      300

gugaccaucc uggacagcag cgaggaggac aaggagaagg aggagguggc cgccgugaag      360

auccaggccg ccuucagagg ccacaucgcc agagaggagg ccaagaagau gaagaccaac      420

agccugcaga acgaggagaa ggaggagaac aaguga                                456


<210>  3456
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SP17__Homo_sapiens__AAH32457

<400>  3456
augagcaucc ccuucuccaa cacccacuac cggauuccuc agggcuuugg gaaucugcuc       60

gagggacuga caagagaaau ccuucgcgag caaccggaca acauucccgc cuucgcugcc      120

gcguauuuug aaucucugcu cgagaagaga gagaaaacga auuucgaucc ugcugagugg      180

ggcagcaagg uggaggaccg guuuuacaac aaucaugccu ucgaagaaca ggaacccccu      240

gagaaauccg aucccaagca ggaggaaucu cagaucagcg ggaaagagga agagaccucc      300

gucacaauuc uggacucuag cgaagaggau aaggagaagg aagagguugc cgcugugaaa      360

auccaagccg cuuuucgcgg acacaucgcc agagaagagg cgaagaaaau gaagaccaac      420

ucccuucaga augaagagaa agaggaaaac aaguga                                456


<210>  3457
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SPNXA__Homo_sapiens__Q9NS26

<400>  3457

Met Asp Lys Gln Ser Ser Ala Gly Gly Val Lys Arg Ser Val Pro Cys 
1               5                   10                  15      


Asp Ser Asn Glu Ala Asn Glu Met Met Pro Glu Thr Pro Thr Gly Asp 
            20                  25                  30          


Ser Asp Pro Gln Pro Ala Pro Lys Lys Met Lys Thr Ser Glu Ser Ser 
        35                  40                  45              


Thr Ile Leu Val Val Arg Tyr Arg Arg Asn Phe Lys Arg Thr Ser Pro 
    50                  55                  60                  


Glu Glu Leu Leu Asn Asp His Ala Arg Glu Asn Arg Ile Asn Pro Leu 
65                  70                  75                  80  


Gln Met Glu Glu Glu Glu Phe Met Glu Ile Met Val Glu Ile Pro Ala 
                85                  90                  95      


Lys 
    


<210>  3458
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SPNXA__Homo_sapiens__AAF28420

<400>  3458
auggacaaac aauccagugc cggcggggug aagaggagcg uccccuguga uuccaacgag       60

gccaacgaga ugaugccgga gaccccaacu ggggacucag acccgcaacc ugcuccuaaa      120

aaaaugaaaa caucugaguc cucgaccaua cuagugguuc gcuacaggag gaacuuuaaa      180

agaacaucuc cagaggaacu gcugaaugac cacgcccgag agaacagaau caacccccuc      240

caaauggagg aggaggaauu cauggaaaua augguugaaa uaccugcaaa guag            294


<210>  3459
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SPNXA__Homo_sapiens__AAF28420

<400>  3459
auggacaagc agagcuccgc cggcggggug aagcgcagcg uccccugcga cuccaacgag       60

gccaacgaga ugaugccgga gacccccacc ggcgacagcg acccccagcc cgcgccgaag      120

aagaugaaga cguccgagag cuccaccauc cugguggugc gguaccgccg gaacuucaag      180

cgcaccagcc ccgaggagcu ccugaacgac cacgcccggg agaaccgcau caacccccug      240

cagauggagg aggaggaguu cauggagauc auggucgaga uccccgccaa guga            294


<210>  3460
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SPNXA__Homo_sapiens__AAF28420

<400>  3460
auggacaagc aguccuccgc cggcggcguc aagcgcuccg uccccugcga cuccaacgag       60

gccaacgaga ugaugcccga gacccccacc ggcgacuccg acccccagcc cgcccccaag      120

aagaugaaga ccuccgaguc cuccaccauc cucgucgucc gcuaccgccg caacuucaag      180

cgcaccuccc ccgaggagcu ccucaacgac cacgcccgcg agaaccgcau caacccccuc      240

cagauggagg aggaggaguu cauggagauc auggucgaga uccccgccaa guga            294


<210>  3461
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SPNXA__Homo_sapiens__AAF28420

<400>  3461
auggacaagc agagcuccgc cggcggggug aaaagaucug uccccugcga uucaaacgag       60

gcuaaugaaa ugaugccuga gaccccaaca ggagacagug auccgcaacc cgcaccuaag      120

aaaaugaaga cuagcgaauc cucuacgauc cugguuguga gguaccggcg caacuucaaa      180

cgaaccucgc cagaggaacu ccuuaaugac cacgcccgug agaacagaau uaauccccug      240

cagauggagg aagaggaauu uauggagaua augguagaga ucccugcgaa guga            294


<210>  3462
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SPNXA__Homo_sapiens__AAF28420

<400>  3462
auggacaagc agagcagcgc cggcggcgug aagagaagcg ugcccugcga cagcaacgag       60

gccaacgaga ugaugcccga gacccccacc ggcgacagcg acccccagcc cgcccccaag      120

aagaugaaga ccagcgagag cagcaccauc cuggugguga gauacagaag aaacuucaag      180

agaaccagcc ccgaggagcu gcugaacgac cacgccagag agaacagaau caacccccug      240

cagauggagg aggaggaguu cauggagauc augguggaga uccccgccaa guga            294


<210>  3463
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SPNXA__Homo_sapiens__AAF28420

<400>  3463
auggacaagc agagcuccgc cggcggggug aaaagaucug uccccugcga uagcaacgag       60

gcuaaugaaa ugaugccuga gaccccgaca ggagacuccg auccccaacc ugcccccaag      120

aaaaugaaga cgucugaaag cuccaccauc cugguugugc gguaccgcag aaacuucaaa      180

cggacaucuc cugaggaacu ccugaaugac cacgcgcgcg agaacagaau uaauccccuu      240

cagauggagg aagaggaauu uauggagauc augguggaga uuccugcuaa guga            294


<210>  3464
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SPXN3__Homo_sapiens__Q5MJ09

<400>  3464

Met Glu Gln Pro Thr Ser Ser Thr Asn Gly Glu Lys Thr Lys Ser Pro 
1               5                   10                  15      


Cys Glu Ser Asn Asn Lys Lys Asn Asp Glu Met Gln Glu Val Pro Asn 
            20                  25                  30          


Arg Val Leu Ala Pro Glu Gln Ser Leu Lys Lys Thr Lys Thr Ser Glu 
        35                  40                  45              


Tyr Pro Ile Ile Phe Val Tyr Tyr Leu Arg Lys Gly Lys Lys Ile Asn 
    50                  55                  60                  


Ser Asn Gln Leu Glu Asn Glu Gln Ser Gln Glu Asn Ser Ile Asn Pro 
65                  70                  75                  80  


Ile Gln Lys Glu Glu Asp Glu Gly Val Asp Leu Ser Glu Gly Ser Ser 
                85                  90                  95      


Asn Glu Asp Glu Asp Leu Gly Pro Cys Glu Gly Pro Ser Lys Glu Asp 
            100                 105                 110         


Lys Asp Leu Asp Ser Ser Glu Gly Ser Ser Gln Glu Asp Glu Asp Leu 
        115                 120                 125             


Gly Leu Ser Glu Gly Ser Ser Gln Asp Ser Gly Glu Asp 
    130                 135                 140     


<210>  3465
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SPXN3__Homo_sapiens__AAH62750

<400>  3465
auggaacagc caacuuccag uaccaauggg gagaagacga agagccccug ugaauccaau       60

aacaaaaaaa augaugagau gcaagaggua ccaaacagag ucuuagcccc cgaacagagu      120

uugaagaaga caaaaacauc agaauaucca auaauauuug uguauuaccu caggaagggu      180

aagaaaauaa auucaaauca acuggagaau gaacaguccc aagagaacuc caucaaucca      240

auccaaaagg aggaggacga aggcguagac uuaucugaag gaucuucaaa ugaggaugaa      300

gaccuaggcc caugugaagg accuucaaag gaggacaaag aucuagacuc aucugaagga      360

uccucacagg aggaugaaga ccuaggcuua ucugaaggau cuucacagga caguggggag      420

gauuag                                                                 426


<210>  3466
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SPXN3__Homo_sapiens__AAH62750

<400>  3466
auggagcagc ccaccagcuc caccaacggc gagaagacca agagcccgug cgaguccaac       60

aacaagaaga acgacgagau gcaggaggug cccaaccgcg uccuggcccc cgagcagagc      120

cucaagaaga cgaagaccuc cgaguacccc aucaucuucg uguacuaccu gcggaagggg      180

aagaagauca acagcaacca gcuggagaac gagcaguccc aggagaacag caucaacccg      240

auccagaagg aggaggacga gggcguggac cucuccgagg ggagcuccaa cgaggacgag      300

gaccugggcc ccugcgaggg gcccagcaag gaggacaagg accuggacuc cagcgagggc      360

uccagccagg aggacgagga ccucggccug uccgagggga gcucccagga cagcggcgag      420

gacuga                                                                 426


<210>  3467
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SPXN3__Homo_sapiens__AAH62750

<400>  3467
auggagcagc ccaccuccuc caccaacggc gagaagacca agucccccug cgaguccaac       60

aacaagaaga acgacgagau gcaggagguc cccaaccgcg uccucgcccc cgagcagucc      120

cucaagaaga ccaagaccuc cgaguacccc aucaucuucg ucuacuaccu ccgcaagggc      180

aagaagauca acuccaacca gcucgagaac gagcaguccc aggagaacuc caucaacccc      240

auccagaagg aggaggacga gggcgucgac cucuccgagg gcuccuccaa cgaggacgag      300

gaccucggcc ccugcgaggg ccccuccaag gaggacaagg accucgacuc cuccgagggc      360

uccucccagg aggacgagga ccucggccuc uccgagggcu ccucccagga cuccggcgag      420

gacuga                                                                 426


<210>  3468
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SPXN3__Homo_sapiens__AAH62750

<400>  3468
auggagcagc ccaccagcuc cacaaacggc gaaaagacua aaucuccuug cgagucaaau       60

aacaagaaaa augacgaaau gcaagaggug ccaaacagag uccuggcccc ggaacagagu      120

cucaagaaaa cgaagaccag cgaguacccc aucauuuucg uuuauuaccu uaggaagggg      180

aaaaagauaa auuccaacca gcuggagaau gaacagucuc aagagaacuc gaucaauccu      240

auucagaaag aagaggauga gggaguggac uugucagaag guagcaguaa cgaggaugaa      300

gacuuaggcc caugugaggg gcccuccaag gaagauaaag accuggauuc uagcgaggga      360

uccucacagg aggacgaaga ucuaggccuc agugagggua gcucucagga cuccggggaa      420

gauuga                                                                 426


<210>  3469
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SPXN3__Homo_sapiens__AAH62750

<400>  3469
auggagcagc ccaccagcag caccaacggc gagaagacca agagccccug cgagagcaac       60

aacaagaaga acgacgagau gcaggaggug cccaacagag ugcuggcccc cgagcagagc      120

cugaagaaga ccaagaccag cgaguacccc aucaucuucg uguacuaccu gagaaagggc      180

aagaagauca acagcaacca gcuggagaac gagcagagcc aggagaacag caucaacccc      240

auccagaagg aggaggacga gggcguggac cugagcgagg gcagcagcaa cgaggacgag      300

gaccugggcc ccugcgaggg ccccagcaag gaggacaagg accuggacag cagcgagggc      360

agcagccagg aggacgagga ccugggccug agcgagggca gcagccagga cagcggcgag      420

gacuga                                                                 426


<210>  3470
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SPXN3__Homo_sapiens__AAH62750

<400>  3470
auggagcagc ccaccagcuc cacaaacggc gaaaagacga aaucuccuug cgagagcaau       60

aacaagaaaa augacgaaau gcaagaggug ccgaacagag uccuggcccc cgaacagucc      120

cucaagaaaa ccaagacauc ugaguacccu aucauuuucg uuuauuaccu gcggaagggg      180

aaaaagauca auagcaacca gcuugagaau gaacaguccc aagagaacuc uauuaauccc      240

auccagaaag aagaggauga gggaguggac cugagcgaag gcuccagcaa cgaggaugaa      300

gaccucgggc cuugugaggg acccucuaag gaagauaaag accuggauuc cagcgagggg      360

ucuucccagg aggacgaaga ucuuggccug agcgagggau cuucccagga cagcggcgaa      420

gauuga                                                                 426


<210>  3471
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SSX-1__Homo_sapiens__Q16384

<400>  3471

Met Asn Gly Asp Asp Thr Phe Ala Lys Arg Pro Arg Asp Asp Ala Lys 
1               5                   10                  15      


Ala Ser Glu Lys Arg Ser Lys Ala Phe Asp Asp Ile Ala Thr Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Lys Lys Met Lys Tyr Ser Glu Lys Ile Ser Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Asn Tyr Lys Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Cys Asn Lys Gln Ala Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp His Asn Arg Arg Ile Gln Val Glu His 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu His Arg Ile Ile Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys 
    130                 135                 140                 


Ala Asn Ile Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  3472
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SSX-1__Homo_sapiens__AAH01003

<400>  3472
augaacggag acgacaccuu ugcaaagaga cccagggaug augcuaaagc aucagagaag       60

agaagcaagg ccuuugauga uauugccaca uacuucucua agaaagagug gaaaaagaug      120

aaauacucgg agaaaaucag cuauguguau augaagagaa acuauaaggc caugacuaaa      180

cuagguuuca aagucacccu cccaccuuuc auguguaaua aacaggccac agacuuccag      240

gggaaugauu uugauaauga ccauaaccgc aggauucagg uugaacaucc ucagaugacu      300

uucggcaggc uccacagaau caucccgaag aucaugccca agaagccagc agaggacgaa      360

aaugauucga agggaguguc agaagcaucu ggcccacaaa acgaugggaa acaacugcac      420

cccccaggaa aagcaaauau uucugagaag auuaauaaga gaucuggacc caaaaggggg      480

aaacaugccu ggacccacag acugcgugag agaaagcagc uggugauuua ugaagagauc      540

agcgacccug aggaagauga cgaguaa                                          567


<210>  3473
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SSX-1__Homo_sapiens__AAH01003

<400>  3473
augaacggcg acgacaccuu cgccaagcgc ccccgggacg acgccaaggc gagcgagaag       60

cgcuccaagg ccuucgacga caucgccacc uacuucagca agaaggagug gaagaagaug      120

aaguacuccg agaagaucag cuacguguac augaagcgga acuacaaggc caugacgaag      180

cugggguuca aggucacccu cccgcccuuc augugcaaca agcaggccac cgacuuccag      240

ggcaacgacu ucgacaacga ccacaaccgc cggauccagg uggagcaccc ccagaugacc      300

uucgggcgcc ugcaccggau cauccccaag aucaugccga agaagcccgc ggaggacgag      360

aacgacucca agggcgugag cgaggccucc gggccccaga acgacggcaa gcagcugcac      420

ccgcccggca aggccaacau cagcgagaag aucaacaagc gcuccgggcc caagcggggc      480

aagcacgccu ggacgcaccg ccuccgggag cgcaagcagc uggucaucua cgaggagauc      540

agcgaccccg aggaggacga cgaguga                                          567


<210>  3474
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SSX-1__Homo_sapiens__AAH01003

<400>  3474
augaacggcg acgacaccuu cgccaagcgc ccccgcgacg acgccaaggc cuccgagaag       60

cgcuccaagg ccuucgacga caucgccacc uacuucucca agaaggagug gaagaagaug      120

aaguacuccg agaagaucuc cuacgucuac augaagcgca acuacaaggc caugaccaag      180

cucggcuuca aggucacccu cccccccuuc augugcaaca agcaggccac cgacuuccag      240

ggcaacgacu ucgacaacga ccacaaccgc cgcauccagg ucgagcaccc ccagaugacc      300

uucggccgcc uccaccgcau cauccccaag aucaugccca agaagcccgc cgaggacgag      360

aacgacucca agggcgucuc cgaggccucc ggcccccaga acgacggcaa gcagcuccac      420

ccccccggca aggccaacau cuccgagaag aucaacaagc gcuccggccc caagcgcggc      480

aagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucaucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3475
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SSX-1__Homo_sapiens__AAH01003

<400>  3475
augaacggcg acgauaccuu cgccaagaga cccagggacg augcuaaagc aagcgagaag       60

cgguccaaag ccuuugacga uaucgcgaca uacuucucua agaaagaaug gaagaagaug      120

aaauauucag agaagauuag uuacguguau augaaacgca auuacaaggc uaugacuaaa      180

cugggguuua aggucacgcu cccuccauuc augugcaaca agcaggccac cgacuuucaa      240

ggaaaugauu ucgacaacga ucacaaucga cguauacagg uugaacaucc gcagaugaca      300

uuugguagac uucacaggau cauucccaaa aucaugccua agaaaccagc agaggacgaa      360

aacgauagca agggcguguc cgaggccucu gggccccaga augacggaaa acaacugcau      420

ccuccaggca aggcuaacau uucggagaaa aucaauaagc ggucaggucc caagcgcggg      480

aaacacgcau ggacucauag auugagggaa cggaagcagu uaguaauaua ugaggaaauc      540

agcgauccug aggaggacga cgaauga                                          567


<210>  3476
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SSX-1__Homo_sapiens__AAH01003

<400>  3476
augaacggcg acgacaccuu cgccaagaga cccagagacg acgccaaggc cagcgagaag       60

agaagcaagg ccuucgacga caucgccacc uacuucagca agaaggagug gaagaagaug      120

aaguacagcg agaagaucag cuacguguac augaagagaa acuacaaggc caugaccaag      180

cugggcuuca aggugacccu gccccccuuc augugcaaca agcaggccac cgacuuccag      240

ggcaacgacu ucgacaacga ccacaacaga agaauccagg uggagcaccc ccagaugacc      300

uucggcagac ugcacagaau cauccccaag aucaugccca agaagcccgc cgaggacgag      360

aacgacagca agggcgugag cgaggccagc ggcccccaga acgacggcaa gcagcugcac      420

ccccccggca aggccaacau cagcgagaag aucaacaaga gaagcggccc caagagaggc      480

aagcacgccu ggacccacag acugagagag agaaagcagc uggugaucua cgaggagauc      540

agcgaccccg aggaggacga cgaguga                                          567


<210>  3477
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SSX-1__Homo_sapiens__AAH01003

<400>  3477
augaacggcg acgauaccuu cgccaagaga ccccgggacg augcuaaagc cagcgagaag       60

cgcuccaaag cguuugacga uaucgcuaca uacuucucua agaaagaaug gaagaagaug      120

aaauauagcg agaagauuuc cuacguguau augaaaagaa auuacaaggc caugacgaaa      180

cugggguuua aggucacccu cccuccguuc augugcaaca agcaggccac agacuuucaa      240

ggaaaugauu ucgacaacga ucacaaucgg cgcauccagg uugaacaucc ccagaugacc      300

uuuggcagac ugcaccggau uaucccuaaa auuaugccca agaaaccugc ugaggacgaa      360

aacgauucua agggggugag cgaggccucc ggaccccaga augacggcaa acaacuucau      420

ccuccgggga aggcuaacau cucugagaaa aucaauaagc gcagcggacc caagagaggc      480

aaacacgccu ggacacaucg gcugcgcgaa agaaagcagc ucgugauuua ugaggaaauc      540

uccgauccug aggaggacga cgaauga                                          567


<210>  3478
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SSX-2__Homo_sapiens__Q16385

<400>  3478

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  3479
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SSX-2__Homo_sapiens__AAH16957

<400>  3479
augaacggag acgacgccuu ugcaaggaga cccacgguug gugcucaaau accagagaag       60

auccaaaagg ccuucgauga uauugccaaa uacuucucua aggaagagug ggaaaagaug      120

aaagccucag agaaaaucuu cuauguguau augaagagaa aguaugaggc uaugacuaaa      180

cuagguuuca aggccacccu cccaccuuuc auguguaaua aacgggccga agacuuccag      240

gggaaugauu uggauaauga cccuaaccgu gggaaucagg uugaacgucc ucagaugacu      300

uucggcaggc uccagggaau cuccccgaag aucaugccca agaagccagc agaggaagga      360

aaugauucgg aggaagugcc agaagcaucu ggcccacaaa augaugggaa agagcugugc      420

cccccgggaa aaccaacuac cucugagaag auucacgaga gaucuggacc caaaaggggg      480

gaacaugccu ggacccacag acugcgugag agaaaacagc uggugauuua ugaagagauc      540

agcgacccug aggaagauga cgaguaa                                          567


<210>  3480
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SSX-2__Homo_sapiens__AAH16957

<400>  3480
augaacggcg acgacgccuu cgcccgccgg cccaccgugg gggcgcagau cccggagaag       60

auccagaagg ccuucgacga caucgccaag uacuucagca aggaggagug ggagaagaug      120

aaggccuccg agaagaucuu cuacgucuac augaagcgca aguacgaggc caugaccaag      180

cugggcuuca aggcgacgcu cccgcccuuc augugcaaca agcgggccga ggacuuccag      240

gggaacgacc uggacaacga ccccaaccgc ggcaaccagg uggagcggcc ccagaugacc      300

uucgggcgcc ugcagggcau cagccccaag aucaugccca agaagcccgc cgaggagggc      360

aacgacuccg aggaggugcc ggaggccagc gggccccaga acgacggcaa ggagcucugc      420

ccgcccggga agcccaccac cuccgagaag auccacgagc ggagcggccc caagcgcggg      480

gagcacgcgu ggacgcaccg gcugcgcgag cggaagcagc uggucaucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3481
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SSX-2__Homo_sapiens__AAH16957

<400>  3481
augaacggcg acgacgccuu cgcccgccgc cccaccgucg gcgcccagau ccccgagaag       60

auccagaagg ccuucgacga caucgccaag uacuucucca aggaggagug ggagaagaug      120

aaggccuccg agaagaucuu cuacgucuac augaagcgca aguacgaggc caugaccaag      180

cucggcuuca aggccacccu cccccccuuc augugcaaca agcgcgccga ggacuuccag      240

ggcaacgacc ucgacaacga ccccaaccgc ggcaaccagg ucgagcgccc ccagaugacc      300

uucggccgcc uccagggcau cucccccaag aucaugccca agaagcccgc cgaggagggc      360

aacgacuccg aggagguccc cgaggccucc ggcccccaga acgacggcaa ggagcucugc      420

ccccccggca agcccaccac cuccgagaag auccacgagc gcuccggccc caagcgcggc      480

gagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucaucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3482
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SSX-2__Homo_sapiens__AAH16957

<400>  3482
augaacggcg acgaugccuu cgcuagaagg cccaccgugg gggcacagau cccugagaag       60

auucaaaaag ccuuugacga uauagcgaag uacuucagca aagaagagug ggaaaagaug      120

aaggcuuccg agaaaaucuu uuaugucuac augaagcgga aauaugaagc caugacaaag      180

cugggauuca aagcaacucu cccaccguuu augugcaaua agcgcgccga ggacuuccag      240

gguaacgauc uugacaauga ucccaaccga ggcaaucagg uugagcgucc ucagaugacg      300

uuugggagac ugcaaggaau uucuccaaaa aucaugccca agaagccugc ugaagagggc      360

aacgacucag aagaggugcc agaggcaagu gguccccaga augaugggaa agaauugugu      420

ccuccaggaa agccgaccac aagcgagaaa auucacgaaa gguccggccc caagcggggc      480

gagcaugccu ggacucaccg cuuaagagaa aggaaacagc ugguaaucua cgaggagaua      540

ucugacccug aagaggauga cgaauga                                          567


<210>  3483
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SSX-2__Homo_sapiens__AAH16957

<400>  3483
augaacggcg acgacgccuu cgccagaaga cccaccgugg gcgcccagau ccccgagaag       60

auccagaagg ccuucgacga caucgccaag uacuucagca aggaggagug ggagaagaug      120

aaggccagcg agaagaucuu cuacguguac augaagagaa aguacgaggc caugaccaag      180

cugggcuuca aggccacccu gccccccuuc augugcaaca agagagccga ggacuuccag      240

ggcaacgacc uggacaacga ccccaacaga ggcaaccagg uggagagacc ccagaugacc      300

uucggcagac ugcagggcau cagccccaag aucaugccca agaagcccgc cgaggagggc      360

aacgacagcg aggaggugcc cgaggccagc ggcccccaga acgacggcaa ggagcugugc      420

ccccccggca agcccaccac cagcgagaag auccacgaga gaagcggccc caagagaggc      480

gagcacgccu ggacccacag acugagagag agaaagcagc uggugaucua cgaggagauc      540

agcgaccccg aggaggacga cgaguga                                          567


<210>  3484
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SSX-2__Homo_sapiens__AAH16957

<400>  3484
augaacggcg acgaugccuu cgcuagacgg cccaccgugg gggcccagau cccugagaag       60

auucaaaaag cguuugacga uaucgcuaag uacuucagca aagaagagug ggaaaagaug      120

aaagccuccg agaagaucuu uuaugucuac augaagcgca aauaugaagc caugacaaag      180

cugggauuca aagcuacgcu cccgcccuuu augugcaaua agagagccga ggacuuccag      240

ggcaacgauc uggacaauga uccuaaccgg gggaaucagg uugagcgccc ccagaugacc      300

uuuggaagac uucaaggcau uucuccuaaa auuaugccca agaagccugc ugaagagggg      360

aacgacagcg aagaggugcc ggaggccucc ggaccccaga augauggcaa agaacugugu      420

ccucccggca agccuacaac cucugagaaa auccacgaac ggagcgggcc caagcgcgga      480

gagcaugcgu ggacacacag acuccgggaa cgcaaacagc uggugaucua cgaggagauu      540

uccgacccgg aagaggauga cgaauga                                          567


<210>  3485
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SSX3__Homo_sapiens__Q99909

<400>  3485

Met Asn Gly Asp Asp Thr Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Val Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Ile Leu Pro Ser Phe Met Arg Asn Lys Arg Val Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Gln Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Val Ser Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile Asn Met Ile Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  3486
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SSX3__Homo_sapiens__AAC05819

<400>  3486
augaacggag augacaccuu ugcaaggaga cccacgguug gugcucaaau accagagaag       60

auacaaaagg ccuucgauga uauugccaaa uacuucucua aggaagagug ggaaaagaug      120

aaagucucgg agaaaaucgu cuauguguau augaagagaa aguaugaggc caugacuaaa      180

cuagguuuca aggccauccu cccaucuuuc augcguaaua aacgggucac agacuuccag      240

gggaaugauu uugauaauga cccuaaccgu gggaaucagg uucaacgucc ucagaugacu      300

uucggcaggc uccagggaau cuucccgaag aucaugccca agaagccagc agaggaagga      360

aauguuucga aggaagugcc agaagcaucu ggcccacaaa acgaugggaa acagcugugc      420

cccccgggaa aaccaacuac cucugagaag auuaacauga uaucuggacc caaaaggggg      480

gaacaugccu ggacccacag acugcgugag agaaagcagc uggugauuua ugaagagauc      540

agcgauccug aggaagauga ugaguaa                                          567


<210>  3487
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SSX3__Homo_sapiens__AAC05819

<400>  3487
augaacggcg acgacaccuu cgcccgccgg cccaccgugg gggcccagau cccggagaag       60

auccagaagg cguucgacga caucgccaag uacuucagca aggaggagug ggagaagaug      120

aaggucuccg agaagaucgu guacguguac augaagcgca aguacgaggc caugacgaag      180

cugggcuuca aggccauccu ccccagcuuc augcggaaca agcgcgucac cgacuuccag      240

gggaacgacu ucgacaacga ccccaaccgg ggcaaccagg ugcagcgccc ccagaugacc      300

uucgggcggc ugcagggcau cuucccgaag aucaugccca agaagcccgc cgaggagggc      360

aacgugucca aggagguccc cgaggcgagc gggccgcaga acgacggcaa gcagcugugc      420

ccgcccggga agcccaccac guccgagaag aucaacauga ucagcggccc caagcgcggg      480

gagcacgccu ggacccaccg gcuccgcgag cggaagcagc uggugaucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3488
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SSX3__Homo_sapiens__AAC05819

<400>  3488
augaacggcg acgacaccuu cgcccgccgc cccaccgucg gcgcccagau ccccgagaag       60

auccagaagg ccuucgacga caucgccaag uacuucucca aggaggagug ggagaagaug      120

aaggucuccg agaagaucgu cuacgucuac augaagcgca aguacgaggc caugaccaag      180

cucggcuuca aggccauccu ccccuccuuc augcgcaaca agcgcgucac cgacuuccag      240

ggcaacgacu ucgacaacga ccccaaccgc ggcaaccagg uccagcgccc ccagaugacc      300

uucggccgcc uccagggcau cuuccccaag aucaugccca agaagcccgc cgaggagggc      360

aacgucucca aggagguccc cgaggccucc ggcccccaga acgacggcaa gcagcucugc      420

ccccccggca agcccaccac cuccgagaag aucaacauga ucuccggccc caagcgcggc      480

gagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucaucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3489
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SSX3__Homo_sapiens__AAC05819

<400>  3489
augaacggcg acgauaccuu cgccagaagg cccacagugg gggcucagau cccugagaag       60

auucaaaaag cauuugacga uauagccaag uacuucagca aagaagagug ggaaaagaug      120

aaagucuccg agaagaucgu uuauguguac augaagcgga aauaugaagc gaugacuaag      180

cugggauuua aagcuauucu cccaucuuuc augcgcaaua agcgaguaac ggacuuucag      240

gguaacgauu ucgacaauga uccgaaccgu ggcaaucagg ugcagagacc ccaaaugacc      300

uuugggaggc uucagggaau cuucccuaaa auuaugccaa agaagcccgc cgaggagggc      360

aacgucucaa aagaagugcc ugaggcaagu gguccacaga augacgggaa gcagcugugc      420

ccucccggaa aaccaacaac uagcgaaaag aucaacauga uauccggccc gaaacggggc      480

gagcacgccu ggacccaucg cuugagagag aggaagcaau uaguuaucua cgaagagauu      540

ucugaucccg aagaggacga ugaauga                                          567


<210>  3490
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SSX3__Homo_sapiens__AAC05819

<400>  3490
augaacggcg acgacaccuu cgccagaaga cccaccgugg gcgcccagau ccccgagaag       60

auccagaagg ccuucgacga caucgccaag uacuucagca aggaggagug ggagaagaug      120

aaggugagcg agaagaucgu guacguguac augaagagaa aguacgaggc caugaccaag      180

cugggcuuca aggccauccu gcccagcuuc augagaaaca agagagugac cgacuuccag      240

ggcaacgacu ucgacaacga ccccaacaga ggcaaccagg ugcagagacc ccagaugacc      300

uucggcagac ugcagggcau cuuccccaag aucaugccca agaagcccgc cgaggagggc      360

aacgugagca aggaggugcc cgaggccagc ggcccccaga acgacggcaa gcagcugugc      420

ccccccggca agcccaccac cagcgagaag aucaacauga ucagcggccc caagagaggc      480

gagcacgccu ggacccacag acugagagag agaaagcagc uggugaucua cgaggagauc      540

agcgaccccg aggaggacga cgaguga                                          567


<210>  3491
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SSX3__Homo_sapiens__AAC05819

<400>  3491
augaacggcg acgauaccuu cgccagacgg cccacagugg gggcucagau cccugagaag       60

auucaaaaag ccuuugacga uaucgcgaag uacuucagca aagaagagug ggaaaagaug      120

aaagucuccg agaagauugu uuauguguac augaagcgca aauaugaagc uaugacgaag      180

cugggauuua aagccauccu cccgucuuuc augagaaaua agcgggugac cgacuuucag      240

ggcaacgauu ucgacaauga ucccaaccgc gggaaucagg uccagagacc ucaaaugaca      300

uuuggacggc ugcagggcau uuuccccaaa aucaugccua agaagcccgc cgaggagggg      360

aacgugagca aagaaguucc ugaggcuucc ggaccgcaga augacggcaa gcagcuuugc      420

ccucccggca aacccaccac aucugaaaag aucaacauga uuagcgggcc uaaacgcgga      480

gagcacgccu ggacccauag acugcgggag cgcaagcaac ucgugaucua cgaagagauu      540

uccgaucccg aagaggacga ugaauga                                          567


<210>  3492
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SSX-4__Homo_sapiens__O60224

<400>  3492

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Arg Asp Asp Ala Gln 
1               5                   10                  15      


Ile Ser Glu Lys Leu Arg Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala Ala Asp Phe His 
65                  70                  75                  80  


Gly Asn Asp Phe Gly Asn Asp Arg Asn His Arg Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Ser Leu Gln Arg Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Glu Asn Gly Leu Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Asn 
    130                 135                 140                 


Pro Ser Thr Leu Glu Lys Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  3493
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SSX-4__Homo_sapiens__AAC05820

<400>  3493
augaacggag acgacgccuu ugcaaggaga cccagggaug augcucaaau aucagagaag       60

uuacgaaagg ccuucgauga uauugccaaa uacuucucua agaaagagug ggaaaagaug      120

aaauccucgg agaaaaucgu cuauguguau augaagcuaa acuaugaggu caugacuaaa      180

cuagguuuca aggucacccu cccaccuuuc augcguagua aacgggcugc agacuuccac      240

gggaaugauu uugguaacga ucgaaaccac aggaaucagg uugaacgucc ucagaugacu      300

uucggcagcc uccagagaau cuucccgaag aucaugccca agaagccagc agaggaagaa      360

aaugguuuga aggaagugcc agaggcaucu ggcccacaaa augaugggaa acagcugugc      420

cccccgggaa auccaaguac cuuggagaag auuaacaaga caucuggacc caaaaggggg      480

aaacaugccu ggacccacag acugcgugag agaaagcagc uggugguuua ugaagagauc      540

agcgacccug aggaagauga cgaguaa                                          567


<210>  3494
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SSX-4__Homo_sapiens__AAC05820

<400>  3494
augaacggcg acgacgccuu cgcccgccgg ccccgcgacg acgcgcagau cagcgagaag       60

cugcggaagg ccuucgacga caucgccaag uacuucucca agaaggagug ggagaagaug      120

aaguccagcg agaagaucgu guacgucuac augaagcuca acuacgaggu gaugaccaag      180

cugggguuca aggugacccu gccgcccuuc augcgcagca agcgggccgc cgacuuccac      240

ggcaacgacu ucgggaacga ccgcaaccac cggaaccagg ucgagcgccc ccagaugacg      300

uucggcuccc uccagcggau cuuccccaag aucaugccga agaagcccgc ggaggaggag      360

aacgggcuga aggaggugcc cgaggccagc ggcccccaga acgacggcaa gcagcugugc      420

ccgcccggga accccuccac ccucgagaag aucaacaaga ccagcggccc caagcgcggg      480

aagcacgccu ggacccaccg gcugcgcgag cggaagcagc ugguggucua cgaggagauc      540

uccgacccgg aggaggacga cgaguga                                          567


<210>  3495
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SSX-4__Homo_sapiens__AAC05820

<400>  3495
augaacggcg acgacgccuu cgcccgccgc ccccgcgacg acgcccagau cuccgagaag       60

cuccgcaagg ccuucgacga caucgccaag uacuucucca agaaggagug ggagaagaug      120

aaguccuccg agaagaucgu cuacgucuac augaagcuca acuacgaggu caugaccaag      180

cucggcuuca aggucacccu cccccccuuc augcgcucca agcgcgccgc cgacuuccac      240

ggcaacgacu ucggcaacga ccgcaaccac cgcaaccagg ucgagcgccc ccagaugacc      300

uucggcuccc uccagcgcau cuuccccaag aucaugccca agaagcccgc cgaggaggag      360

aacggccuca aggagguccc cgaggccucc ggcccccaga acgacggcaa gcagcucugc      420

ccccccggca accccuccac ccucgagaag aucaacaaga ccuccggccc caagcgcggc      480

aagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucgucua cgaggagauc      540

uccgaccccg aggaggacga cgaguga                                          567


<210>  3496
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SSX-4__Homo_sapiens__AAC05820

<400>  3496
augaacggcg acgaugccuu cgcuagaagg ccccgggacg augcacagau cagcgagaag       60

cugcgcaaag ccuuugacga uauugcgaag uacuucucca aaaaggaaug ggagaaaaug      120

aagucuucag aaaagauagu guaugucuac augaaacuca auuaugaggu uaugaccaaa      180

cuuggguuua aggugacacu gccuccauuc augcgaagua agcgugcugc cgacuuucac      240

ggaaacgauu ucgguaauga cagaaaccau aggaaucaag uagaacggcc gcagaugacu      300

uuuggcagcu ugcagcgcau cuuccccaaa auuaugccua agaagccagc agaggaggaa      360

aacggguuaa aagaggugcc cgaagccucc ggaccucaga augauggcaa gcaacugugc      420

ccacccggua acccuucuac gcuagagaaa aucaauaaga ccucggggcc aaaaagagga      480

aagcacgcuu ggacacauag gcuccgggag cgcaaacagc uggucgugua cgaagagauu      540

ucagacccgg aagaggauga cgaauga                                          567


<210>  3497
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SSX-4__Homo_sapiens__AAC05820

<400>  3497
augaacggcg acgacgccuu cgccagaaga cccagagacg acgcccagau cagcgagaag       60

cugagaaagg ccuucgacga caucgccaag uacuucagca agaaggagug ggagaagaug      120

aagagcagcg agaagaucgu guacguguac augaagcuga acuacgaggu gaugaccaag      180

cugggcuuca aggugacccu gccccccuuc augagaagca agagagccgc cgacuuccac      240

ggcaacgacu ucggcaacga cagaaaccac agaaaccagg uggagagacc ccagaugacc      300

uucggcagcc ugcagagaau cuuccccaag aucaugccca agaagcccgc cgaggaggag      360

aacggccuga aggaggugcc cgaggccagc ggcccccaga acgacggcaa gcagcugugc      420

ccccccggca accccagcac ccuggagaag aucaacaaga ccagcggccc caagagaggc      480

aagcacgccu ggacccacag acugagagag agaaagcagc ugguggugua cgaggagauc      540

agcgaccccg aggaggacga cgaguga                                          567


<210>  3498
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SSX-4__Homo_sapiens__AAC05820

<400>  3498
augaacggcg acgaugccuu cgcuagacgg ccccgcgacg augcccagau cagcgagaag       60

cugagaaaag cguuugacga uauugcuaag uacuucucca aaaaggaaug ggagaaaaug      120

aagucuagcg aaaagaucgu guaugucuac augaaacuca auuaugaggu uaugaccaag      180

cugggguuua aagugacacu uccuccguuc augcggucca agcgcgccgc cgacuuucac      240

ggaaacgauu ucggcaauga cagaaaccau cggaaucaag uggaacgccc ccagaugacg      300

uuugggucuc ugcagagaau uuucccuaaa aucaugccca agaagccugc ugaggaggaa      360

aacggacuca aagagguccc cgaagccagc ggcccucaga augaugggaa gcaacugugc      420

ccgcccggaa acccuuccac ccuugagaaa auuaauaaga caucuggccc caaacggggc      480

aagcacgcuu ggacccaucg ccugagagag cggaaacagc ucgugguuua cgaagagauc      540

agcgacccug aagaggauga cgaauga                                          567


<210>  3499
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ST1A1__Homo_sapiens__P50225

<400>  3499

Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys 
1               5                   10                  15      


Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln 
            20                  25                  30          


Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Ser Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly 
    50                  55                  60                  


Gly Asp Leu Glu Lys Cys His Arg Ala Pro Ile Phe Met Arg Val Pro 
65                  70                  75                  80  


Phe Leu Glu Phe Lys Ala Pro Gly Ile Pro Ser Gly Met Glu Thr Leu 
                85                  90                  95      


Lys Asp Thr Pro Ala Pro Arg Leu Leu Lys Thr His Leu Pro Leu Ala 
            100                 105                 110         


Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val 
        115                 120                 125             


Ala Arg Asn Ala Lys Asp Val Ala Val Ser Tyr Tyr His Phe Tyr His 
    130                 135                 140                 


Met Ala Lys Val His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu 
145                 150                 155                 160 


Lys Phe Met Val Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val 
                165                 170                 175     


Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe 
            180                 185                 190         


Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu 
        195                 200                 205             


Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Val Asp Phe Val Val 
    210                 215                 220                 


Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr 
225                 230                 235                 240 


Thr Thr Val Pro Gln Glu Phe Met Asp His Ser Ile Ser Pro Phe Met 
                245                 250                 255     


Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln 
            260                 265                 270         


Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser 
        275                 280                 285             


Leu Ser Phe Arg Ser Glu Leu 
    290                 295 


<210>  3500
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ST1A1__Homo_sapiens__CCDS32420.1

<400>  3500
auggagcuga uccaggacac cucccgcccg ccacuggagu acgugaaggg ggucccgcuc       60

aucaaguacu uugcagaggc acuggggccc cugcagagcu uccaggcccg gccugaugac      120

cugcucauca gcaccuaccc caaguccggc acuaccuggg uaagccagau ucuggacaug      180

aucuaccagg guggugaccu ggagaagugu caccgagcuc ccaucuucau gcgggugccc      240

uuccuugagu ucaaagcccc agggauuccc ucagggaugg agacucugaa agacacaccg      300

gccccacgac uccugaagac acaccugccc cuggcucugc ucccccagac ucuguuggau      360

cagaagguca agguggucua uguugcccgc aacgcaaagg auguggcagu uuccuacuac      420

cacuucuacc acauggccaa ggugcacccu gagccuggga ccugggacag cuuccuggag      480

aaguucaugg ucggagaagu guccuacgga uccugguacc agcacgugca ggaguggugg      540

gagcugagcc gcacccaccc uguucucuac cucuucuaug aagacaugaa ggagaacccg      600

aaaagggaga uucaaaagau ccuggaguuu guggggcgcu cccugccaga ggagaccgug      660

gacuucgugg uucagcacac gucguucaag gagaugaaga agaacccuau gaccaacuac      720

accaccgucc cccaggaguu cauggaccac agcaucuccc ccuucaugag gaaaggcaug      780

gcuggggacu ggaagaccac cuucaccgug gcgcagaaug agcgcuucga ugcggacuau      840

gcggagaaga uggcaggcug cagccucagc uuccgcucug agcuguga                   888


<210>  3501
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ST1A1__Homo_sapiens__CCDS32420.1

<400>  3501
auggagcuga uccaggacac cagccggccc ccgcucgagu acgugaaggg cgucccccug       60

aucaaguacu ucgccgaggc ccuggggccc cuccaguccu uccaggcgcg ccccgacgac      120

cugcugauca gcaccuaccc gaaguccggc acgaccuggg ugagccagau ccucgacaug      180

aucuaccagg gcggggaccu ggagaagugc caccgcgccc ccaucuucau gcgggugccc      240

uuccuggagu ucaaggcccc cgggaucccg uccggcaugg agacccucaa ggacaccccc      300

gcgccccgcc ugcugaagac gcaccucccc cuggcccugc ucccgcagac ccugcuggac      360

cagaagguca agguggugua cgucgcccgg aacgccaagg acguggccgu gagcuacuac      420

cacuucuacc acauggccaa gguccacccc gagcccggca ccugggacuc cuuccucgag      480

aaguucaugg ugggggaggu gagcuacggc uccugguacc agcacgucca ggaguggugg      540

gagcugagcc gcacccaccc cgugcuguac cucuucuacg aggacaugaa ggagaacccg      600

aagcgggaga uccagaagau ccuggaguuc guggggcgcu cccugcccga ggagacgguc      660

gacuucgugg ugcagcacac cagcuucaag gagaugaaga agaaccccau gaccaacuac      720

accacggucc cccaggaguu cauggaccac uccaucagcc cguucaugcg gaagggcaug      780

gcgggggacu ggaagaccac cuucaccgug gcccagaacg agcgcuucga cgccgacuac      840

gccgagaaga uggccggcug cucccucagc uuccgguccg agcuguga                   888


<210>  3502
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ST1A1__Homo_sapiens__CCDS32420.1

<400>  3502
auggagcuca uccaggacac cucccgcccc ccccucgagu acgucaaggg cgucccccuc       60

aucaaguacu ucgccgaggc ccucggcccc cuccaguccu uccaggcccg ccccgacgac      120

cuccucaucu ccaccuaccc caaguccggc accaccuggg ucucccagau ccucgacaug      180

aucuaccagg gcggcgaccu cgagaagugc caccgcgccc ccaucuucau gcgcgucccc      240

uuccucgagu ucaaggcccc cggcaucccc uccggcaugg agacccucaa ggacaccccc      300

gccccccgcc uccucaagac ccaccucccc cucgcccucc ucccccagac ccuccucgac      360

cagaagguca aggucgucua cgucgcccgc aacgccaagg acgucgccgu cuccuacuac      420

cacuucuacc acauggccaa gguccacccc gagcccggca ccugggacuc cuuccucgag      480

aaguucaugg ucggcgaggu cuccuacggc uccugguacc agcacgucca ggaguggugg      540

gagcucuccc gcacccaccc cguccucuac cucuucuacg aggacaugaa ggagaacccc      600

aagcgcgaga uccagaagau ccucgaguuc gucggccgcu cccuccccga ggagaccguc      660

gacuucgucg uccagcacac cuccuucaag gagaugaaga agaaccccau gaccaacuac      720

accaccgucc cccaggaguu cauggaccac uccaucuccc ccuucaugcg caagggcaug      780

gccggcgacu ggaagaccac cuucaccguc gcccagaacg agcgcuucga cgccgacuac      840

gccgagaaga uggccggcug cucccucucc uuccgcuccg agcucuga                   888


<210>  3503
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ST1A1__Homo_sapiens__CCDS32420.1

<400>  3503
auggagcuga uccaggacac cagcagaccc ccucucgaau acgugaaggg cgucccacuu       60

auuaaauauu ucgccgaggc ucuggggccg uugcaauccu uucaggcaag gcccgaugac      120

uuacugauau cuacauaccc uaagucagga acuacguggg uuagucagau ccuagauaug      180

auuuaucagg guggcgaccu cgaaaaaugc caccgggccc caaucuucau gcgcgugccc      240

uuucuggagu ucaaggcgcc ugggauucca agcggaaugg aaacccuuaa agauacaccc      300

gcuccucgac uguugaagac ucaucuccca cuggcccugc ucccgcaaac cuuacuggac      360

cagaagguaa aaguggucua cguggcacgu aacgccaagg auguugcugu guccuauuac      420

cacuuuuauc auauggcaaa aguccacccc gagccuggca caugggacuc uuuccuugag      480

aaguuuaugg ugggugaagu aucguacggg ucaugguacc agcauguuca ggaguggugg      540

gaauugagca gaacccaccc agugcuguau cuauucuacg aggauaugaa agagaauccc      600

aagagggaaa uccaaaagau acucgaguuu gucggacgga gucugccuga agagacugug      660

gacuucgugg uccagcacac auccuuuaaa gaaaugaaga aaaacccaau gaccaauuau      720

acgacuguuc cccaggaguu cauggaucau ucuaucagcc cguuuaugcg caagggcaug      780

gccggcgacu ggaaaaccac auucacugug gcucagaacg agagauucga ugccgacuac      840

gcggaaaaga uggcagggug uucccuuuca uuuaggagug agcuguga                   888


<210>  3504
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ST1A1__Homo_sapiens__CCDS32420.1

<400>  3504
auggagcuga uccaggacac cagcagaccc ccccuggagu acgugaaggg cgugccccug       60

aucaaguacu ucgccgaggc ccugggcccc cugcagagcu uccaggccag acccgacgac      120

cugcugauca gcaccuaccc caagagcggc accaccuggg ugagccagau ccuggacaug      180

aucuaccagg gcggcgaccu ggagaagugc cacagagccc ccaucuucau gagagugccc      240

uuccuggagu ucaaggcccc cggcaucccc agcggcaugg agacccugaa ggacaccccc      300

gcccccagac ugcugaagac ccaccugccc cuggcccugc ugccccagac ccugcuggac      360

cagaagguga agguggugua cguggccaga aacgccaagg acguggccgu gagcuacuac      420

cacuucuacc acauggccaa ggugcacccc gagcccggca ccugggacag cuuccuggag      480

aaguucaugg ugggcgaggu gagcuacggc agcugguacc agcacgugca ggaguggugg      540

gagcugagca gaacccaccc cgugcuguac cuguucuacg aggacaugaa ggagaacccc      600

aagagagaga uccagaagau ccuggaguuc gugggcagaa gccugcccga ggagaccgug      660

gacuucgugg ugcagcacac cagcuucaag gagaugaaga agaaccccau gaccaacuac      720

accaccgugc cccaggaguu cauggaccac agcaucagcc ccuucaugag aaagggcaug      780

gccggcgacu ggaagaccac cuucaccgug gcccagaacg agagauucga cgccgacuac      840

gccgagaaga uggccggcug cagccugagc uucagaagcg agcuguga                   888


<210>  3505
<211>  888
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ST1A1__Homo_sapiens__CCDS32420.1

<400>  3505
auggagcuga uccaggacac cagcagaccc ccucucgaau acgugaaggg cgucccgcug       60

auuaaauauu ucgccgaggc ucuugggccc cugcaauccu uucaggcccg gccugaugac      120

cuccugaucu cuacauaccc caagagcgga acgaccuggg uuucccagau ucuugauaug      180

aucuaucagg gcggggaccu ggaaaaaugc caccgcgcgc cuauuuucau gagagugccc      240

uuucucgagu ucaaggcucc uggaaucccg ucuggcaugg aaacacugaa agauaccccc      300

gccccucggc ugcucaagac acaucugccc cuugcccugc ucccucaaac ccugcuugac      360

cagaagguga aagucgugua cguugcucgc aacgccaagg auguggcugu cagcuauuac      420

cacuuuuauc auauggccaa agugcacccc gagccgggga caugggacuc cuuccuggag      480

aaguuuaugg uuggagaagu gucuuacggc agcugguacc agcaugucca ggaguggugg      540

gaacucucca gaacccaccc ugugcuguau cuguucuacg aggauaugaa agagaauccc      600

aagcgggaaa uccaaaagau ucucgaguuu gugggccgca gccugccuga agagacgguc      660

gacuucguug ugcagcacac cucuuuuaaa gaaaugaaga aaaaccccau gacaaauuau      720

accacagugc cccaggaguu cauggaucau uccaucagcc cuuuuaugag aaaggggaug      780

gcgggagacu ggaaaaccac guucacaguc gcccagaacg agcgguucga ugcugacuac      840

gccgaaaaga uggcuggcug uucucuuucc uuucgcagcg agcuguga                   888


<210>  3506
<211>  1268
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  STAG2__Homo_sapiens__Q8N3U4-2

<400>  3506

Met Ile Ala Ala Pro Glu Ile Pro Thr Asp Phe Asn Leu Leu Gln Glu 
1               5                   10                  15      


Ser Glu Thr His Phe Ser Ser Asp Thr Asp Phe Glu Asp Ile Glu Gly 
            20                  25                  30          


Lys Asn Gln Lys Gln Gly Lys Gly Lys Thr Cys Lys Lys Gly Lys Lys 
        35                  40                  45              


Gly Pro Ala Glu Lys Gly Lys Gly Gly Asn Gly Gly Gly Lys Pro Pro 
    50                  55                  60                  


Ser Gly Pro Asn Arg Met Asn Gly His His Gln Gln Asn Gly Val Glu 
65                  70                  75                  80  


Asn Met Met Leu Phe Glu Val Val Lys Met Gly Lys Ser Ala Met Gln 
                85                  90                  95      


Ser Val Val Asp Asp Trp Ile Glu Ser Tyr Lys His Asp Arg Asp Ile 
            100                 105                 110         


Ala Leu Leu Asp Leu Ile Asn Phe Phe Ile Gln Cys Ser Gly Cys Lys 
        115                 120                 125             


Gly Val Val Thr Ala Glu Met Phe Arg His Met Gln Asn Ser Glu Ile 
    130                 135                 140                 


Ile Arg Lys Met Thr Glu Glu Phe Asp Glu Asp Ser Gly Asp Tyr Pro 
145                 150                 155                 160 


Leu Thr Met Ala Gly Pro Gln Trp Lys Lys Phe Lys Ser Ser Phe Cys 
                165                 170                 175     


Glu Phe Ile Gly Val Leu Val Arg Gln Cys Gln Tyr Ser Ile Ile Tyr 
            180                 185                 190         


Asp Glu Tyr Met Met Asp Thr Val Ile Ser Leu Leu Thr Gly Leu Ser 
        195                 200                 205             


Asp Ser Gln Val Arg Ala Phe Arg His Thr Ser Thr Leu Ala Ala Met 
    210                 215                 220                 


Lys Leu Met Thr Ala Leu Val Asn Val Ala Leu Asn Leu Ser Ile Asn 
225                 230                 235                 240 


Met Asp Asn Thr Gln Arg Gln Tyr Glu Ala Glu Arg Asn Lys Met Ile 
                245                 250                 255     


Gly Lys Arg Ala Asn Glu Arg Leu Glu Leu Leu Leu Gln Lys Arg Lys 
            260                 265                 270         


Glu Leu Gln Glu Asn Gln Asp Glu Ile Glu Asn Met Met Asn Ala Ile 
        275                 280                 285             


Phe Lys Gly Val Phe Val His Arg Tyr Arg Asp Ala Ile Ala Glu Ile 
    290                 295                 300                 


Arg Ala Ile Cys Ile Glu Glu Ile Gly Ile Trp Met Lys Met Tyr Ser 
305                 310                 315                 320 


Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr Val Gly Trp Thr Met 
                325                 330                 335     


His Asp Lys Gln Gly Glu Val Arg Leu Lys Cys Leu Thr Ala Leu Gln 
            340                 345                 350         


Gly Leu Tyr Tyr Asn Lys Glu Leu Asn Ser Lys Leu Glu Leu Phe Thr 
        355                 360                 365             


Ser Arg Phe Lys Asp Arg Ile Val Ser Met Thr Leu Asp Lys Glu Tyr 
    370                 375                 380                 


Asp Val Ala Val Gln Ala Ile Lys Leu Leu Thr Leu Val Leu Gln Ser 
385                 390                 395                 400 


Ser Glu Glu Val Leu Thr Ala Glu Asp Cys Glu Asn Val Tyr His Leu 
                405                 410                 415     


Val Tyr Ser Ala His Arg Pro Val Ala Val Ala Ala Gly Glu Phe Leu 
            420                 425                 430         


Tyr Lys Lys Leu Phe Ser Arg Arg Asp Pro Glu Glu Asp Gly Met Met 
        435                 440                 445             


Lys Arg Arg Gly Arg Gln Gly Pro Asn Ala Asn Leu Val Lys Thr Leu 
    450                 455                 460                 


Val Phe Phe Phe Leu Glu Ser Glu Leu His Glu His Ala Ala Tyr Leu 
465                 470                 475                 480 


Val Asp Ser Met Trp Asp Cys Ala Thr Glu Leu Leu Lys Asp Trp Glu 
                485                 490                 495     


Cys Met Asn Ser Leu Leu Leu Glu Glu Pro Leu Ser Gly Glu Glu Ala 
            500                 505                 510         


Leu Thr Asp Arg Gln Glu Ser Ala Leu Ile Glu Ile Met Leu Cys Thr 
        515                 520                 525             


Ile Arg Gln Ala Ala Glu Cys His Pro Pro Val Gly Arg Gly Thr Gly 
    530                 535                 540                 


Lys Arg Val Leu Thr Ala Lys Glu Lys Lys Thr Gln Leu Asp Asp Arg 
545                 550                 555                 560 


Thr Lys Ile Thr Glu Leu Phe Ala Val Ala Leu Pro Gln Leu Leu Ala 
                565                 570                 575     


Lys Tyr Ser Val Asp Ala Glu Lys Val Thr Asn Leu Leu Gln Leu Pro 
            580                 585                 590         


Gln Tyr Phe Asp Leu Glu Ile Tyr Thr Thr Gly Arg Leu Glu Lys His 
        595                 600                 605             


Leu Asp Ala Leu Leu Arg Gln Ile Arg Asn Ile Val Glu Lys His Thr 
    610                 615                 620                 


Asp Thr Asp Val Leu Glu Ala Cys Ser Lys Thr Tyr His Ala Leu Cys 
625                 630                 635                 640 


Asn Glu Glu Phe Thr Ile Phe Asn Arg Val Asp Ile Ser Arg Ser Gln 
                645                 650                 655     


Leu Ile Asp Glu Leu Ala Asp Lys Phe Asn Arg Leu Leu Glu Asp Phe 
            660                 665                 670         


Leu Gln Glu Gly Glu Glu Pro Asp Glu Asp Asp Ala Tyr Gln Val Leu 
        675                 680                 685             


Ser Thr Leu Lys Arg Ile Thr Ala Phe His Asn Ala His Asp Leu Ser 
    690                 695                 700                 


Lys Trp Asp Leu Phe Ala Cys Asn Tyr Lys Leu Leu Lys Thr Gly Ile 
705                 710                 715                 720 


Glu Asn Gly Asp Met Pro Glu Gln Ile Val Ile His Ala Leu Gln Cys 
                725                 730                 735     


Thr His Tyr Val Ile Leu Trp Gln Leu Ala Lys Ile Thr Glu Ser Ser 
            740                 745                 750         


Ser Thr Lys Glu Asp Leu Leu Arg Leu Lys Lys Gln Met Arg Val Phe 
        755                 760                 765             


Cys Gln Ile Cys Gln His Tyr Leu Thr Asn Val Asn Thr Thr Val Lys 
    770                 775                 780                 


Glu Gln Ala Phe Thr Ile Leu Cys Asp Ile Leu Met Ile Phe Ser His 
785                 790                 795                 800 


Gln Ile Met Ser Gly Gly Arg Asp Met Leu Glu Pro Leu Val Tyr Thr 
                805                 810                 815     


Pro Asp Ser Ser Leu Gln Ser Glu Leu Leu Ser Phe Ile Leu Asp His 
            820                 825                 830         


Val Phe Ile Glu Gln Asp Asp Asp Asn Asn Ser Ala Asp Gly Gln Gln 
        835                 840                 845             


Glu Asp Glu Ala Ser Lys Ile Glu Ala Leu His Lys Arg Arg Asn Leu 
    850                 855                 860                 


Leu Ala Ala Phe Cys Lys Leu Ile Val Tyr Thr Val Val Glu Met Asn 
865                 870                 875                 880 


Thr Ala Ala Asp Ile Phe Lys Gln Tyr Met Lys Tyr Tyr Asn Asp Tyr 
                885                 890                 895     


Gly Asp Ile Ile Lys Glu Thr Met Ser Lys Thr Arg Gln Ile Asp Lys 
            900                 905                 910         


Ile Gln Cys Ala Lys Thr Leu Ile Leu Ser Leu Gln Gln Leu Phe Asn 
        915                 920                 925             


Glu Met Ile Gln Glu Asn Gly Tyr Asn Phe Asp Arg Ser Ser Ser Thr 
    930                 935                 940                 


Phe Ser Gly Ile Lys Glu Leu Ala Arg Arg Phe Ala Leu Thr Phe Gly 
945                 950                 955                 960 


Leu Asp Gln Leu Lys Thr Arg Glu Ala Ile Ala Met Leu His Lys Asp 
                965                 970                 975     


Gly Ile Glu Phe Ala Phe Lys Glu Pro Asn Pro Gln Gly Glu Ser His 
            980                 985                 990         


Pro Pro Leu Asn Leu Ala Phe Leu Asp Ile Leu Ser Glu Phe Ser Ser 
        995                 1000                1005            


Lys Leu Leu Arg Gln Asp Lys Arg Thr Val Tyr Val Tyr Leu Glu Lys 
    1010                1015                1020                


Phe Met Thr Phe Gln Met Ser Leu Arg Arg Glu Asp Val Trp Leu Pro 
1025                1030                1035                1040


Leu Met Ser Tyr Arg Asn Ser Leu Leu Ala Gly Gly Asp Asp Asp Thr 
                1045                1050                1055    


Met Ser Val Ile Ser Gly Ile Ser Ser Arg Gly Ser Thr Val Arg Ser 
            1060                1065                1070        


Lys Lys Ser Lys Pro Ser Thr Gly Lys Arg Lys Val Val Glu Gly Met 
        1075                1080                1085            


Gln Leu Ser Leu Thr Glu Glu Ser Ser Ser Ser Asp Ser Met Trp Leu 
    1090                1095                1100                


Ser Arg Glu Gln Thr Leu His Thr Pro Val Met Met Gln Thr Pro Gln 
1105                1110                1115                1120


Leu Thr Ser Thr Ile Met Arg Glu Pro Lys Arg Leu Arg Pro Glu Asp 
                1125                1130                1135    


Ser Phe Met Ser Val Tyr Pro Met Gln Thr Glu His His Gln Thr Pro 
            1140                1145                1150        


Leu Asp Tyr Asn Thr Gln Val Thr Trp Met Leu Ala Gln Arg Gln Gln 
        1155                1160                1165            


Glu Glu Ala Arg Gln Gln Gln Glu Arg Ala Ala Met Ser Tyr Val Lys 
    1170                1175                1180                


Leu Arg Thr Asn Leu Gln His Ala Ile Arg Arg Gly Thr Ser Leu Met 
1185                1190                1195                1200


Glu Asp Asp Glu Glu Pro Ile Val Glu Asp Val Met Met Ser Ser Glu 
                1205                1210                1215    


Gly Arg Ile Glu Asp Leu Asn Glu Gly Met Asp Phe Asp Thr Met Asp 
            1220                1225                1230        


Ile Asp Leu Pro Pro Ser Lys Asn Arg Arg Glu Arg Thr Glu Leu Lys 
        1235                1240                1245            


Pro Asp Phe Phe Asp Pro Ala Ser Ile Met Asp Glu Ser Val Leu Gly 
    1250                1255                1260                


Val Ser Met Phe 
1265            


<210>  3507
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  STAG2__Homo_sapiens__CCDS43990.1

<400>  3507
augauagcag cuccagaaau accaacugau uuuaaucuac uacaggaguc agaaacacau       60

uuuucuucug acacagauuu ugaagauauc gaaggaaaaa accaaaagca aggcaaaggc      120

aaaacuugua aaaaaggcaa aaagggccca gcagaaaagg gcaaaggugg aaauggagga      180

ggaaaaccuc cuucuggucc aaaccgaaug aauggucauc accaacagaa uggaguggaa      240

aacaugaugu uguuugaagu uguuaaaaug ggcaagagug cuaugcaguc ggugguagau      300

gauuggauag aaucauacaa gcaugaccga gauauagcac uucuugaccu uaucaacuuu      360

uuuauucagu guucaggcug uaaaggaguu gucacagcag aaauguuuag acauaugcag      420

aacucugaga uaauucgaaa aaugacugaa gaauucgaug aggauagugg agauuaucca      480

cuuaccaugg cugguccuca guggaagaag uucaaaucca guuuuuguga auucauuggc      540

guguuaguac ggcaauguca auauaguauc auauaugaug aguauaugau ggauacaguc      600

auuucacuuc uuacaggauu gucugacuca caagucagag cauuucgaca uacaagcacc      660

cuggcagcua ugaaguugau gacagcuuug gugaaugugg cacuaaaucu uagcauuaau      720

auggauaaua cacaaagaca auaugaagca gaacggaaua aaaugauugg aaaacgagcc      780

aaugagaggc uagaacuccu gcuacaaaag cggaaagagc uucaggaaaa ucaagaugaa      840

auagaaaaua ugaugaaugc aauauuuaaa ggaguguuug uacauagaua ccgugaugcg      900

auagcugaaa uucgagcuau uugcauugaa gagauuggca uuuggaugaa gauguauagu      960

gaugccuuuc uuaaugacag uuauuuaaaa uauguugguu ggacuaugca ugauaagcaa     1020

ggugaaguaa gacucaaaug ucuuacugcu cuacaagggc uuuauuauaa caaagagcuu     1080

aauuccaaac uggaacuuuu uaccagucgg uucaaggaua gaauuguguc uaugacccuu     1140

gacaaagaau augauguugc aguacaagca auaaaauuac ucacucuugu uuuacagagu     1200

agugaagaag uucucacugc agaagauugu gaaaaugucu aucaucuggu uuauucagcu     1260

caccggccag uagcaguagc agcuggagaa uuucucuaca aaaagcucuu cagucguaga     1320

gauccagagg aggauggaau gaugaaaaga agaggaagac aagguccaaa ugccaaccuu     1380

guuaagacau ugguuuuuuu cuuucuagaa agugaguuac augagcaugc agcauaccuu     1440

guggauagca ugugggacug ugcuacugag cugcugaaag acugggaaug uaugaauagc     1500

uuguuacugg aagagccacu uaguggagag gaagcacuaa cagauaggca agagagugcu     1560

cugauugaaa uaaugcuuug uaccauuaga caagcggcug aaugucaucc ucccguggga     1620

agagggacag gaaaaagggu gcuuacagca aaggagaaga agacacaguu ggaugauagg     1680

acaaaaauca cugagcuuuu ugccguggcc cuuccucagu uauuagcaaa auacucugua     1740

gaugcagaaa aggugacuaa cuuguugcag uugccucagu acuuugauuu ggaaauauau     1800

accacuggac gauuagaaaa gcauuuggau gccuuauugc gacagauccg gaauauugua     1860

gagaagcaca cagauacaga uguuuuggaa gcauguucua aaacuuacca ugcacucugu     1920

aaugaagagu ucacaaucuu caacagagua gauauuucaa gaagucaacu gauagaugaa     1980

uuggcagaua aauuuaaccg gcuucuugaa gauuuucugc aagaggguga agaaccugau     2040

gaagaugaug cauaucaggu auugucaaca uugaagagga ucacugcuuu ucauaaugcc     2100

caugaccuuu caaaguggga uuuauuugcu uguaauuaca aacucuugaa aacuggaauc     2160

gaaaauggag acaugccuga gcagauuguu auucacgcac ugcaguguac ucacuaugua     2220

auccuuuggc aacuugcuaa gauaacugaa agcagcucua caaaggagga cuugcugcgu     2280

uuaaagaaac aaaugagagu auuuugucag auaugucaac auuaccugac caacgugaau     2340

acuacuguua aggaacaggc cuucacuauu cugugugaua uuuugaugau cuucagccau     2400

cagauuaugu caggagggcg ugacauguua gagccauuag uguauacccc ugauucuuca     2460

uugcagucug aguugcucag cuuuauuuug gaucaugucu ucauugaaca ggaugaugau     2520

aauaauagug cagaugguca gcaagaggau gaagccagua aaauugaagc ucugcacaag     2580

agaagaaauu uacuugcagc auuuuguaag cuaauuguau auacuguggu ggagaugaau     2640

acagcugcag auaucuucaa acaguauaug aaguauuaua augacuaugg agauaucauc     2700

aaagaaacaa ugaguaaaac aaggcagaua gacaaaauuc agugugcuaa gacccuuauu     2760

cucagucugc aacagcuuuu uaaugaaaug auacaagaaa auggcuauaa uuuugauaga     2820

ucauccucua cauuuagugg cauaaaagaa cuugcucgac guuuugcuuu aacuuuugga     2880

cuugaucagu ugaaaacaag agaagccauu gccaugcuac acaaagaugg cauagaauuu     2940

gcuuuuaaag agccuaaucc gcaaggggag agccauccac cuuuaaauuu ggcauuucuu     3000

gauauucuga gugaauuuuc uucuaaacua cuucgacaag acaaaagaac aguguauguu     3060

uacuuggaaa aguucaugac cuuucagaug ucacuccgaa gagaggaugu guggcuucca     3120

cugaugucuu accgaaauuc uuugcuagcu gguggugaug augacaccau gucagucauu     3180

aguggaauca gcagccgggg gucaacagua cggaguaaaa aaucaaaacc aucuacagga     3240

aaacggaaag ugguugaggg caugcagcuu ucacucacug aagaaaguag uaguagugac     3300

aguauguggu uaagcagaga acaaacacug cacaccccug uuaugaugca gacaccacaa     3360

cucaccucca cuauuaugag agagcccaaa agauuacggc cugaggauag cuucaugagu     3420

guuuauccaa ugcagacuga acaucaucaa acaccucuug auuauaacac gcagguaaca     3480

uggauguuag cucaaagaca acaagaggaa gcaaggcaac agcaggagag agcagcaaug     3540

agcuauguua aacugcgaac uaaucuucag caugccauuc ggcguggcac aagccuaaug     3600

gaagaugaug aagagccaau uguggaagau guuaugaugu ccucagaagg gaggauugag     3660

gaucuuaaug agggaaugga uuuugacacc auggauauag auuugccacc aucaaagaac     3720

agacgagaga gaacagaacu gaagccugau uucuuugauc cagcuucaau uauggaugaa     3780

ucaguucuug gagugucaau guuuuaa                                         3807


<210>  3508
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       STAG2__Homo_sapiens__CCDS43990.1

<400>  3508
augaucgccg cccccgagau cccgaccgac uucaaccugc uccaggagag cgagacccac       60

uucuccagcg acacggacuu cgaggacauc gagggcaaga accagaagca ggggaagggc      120

aagaccugca agaaggggaa gaagggcccc gcggagaagg ggaagggcgg caacgggggc      180

gggaagccgc ccuccggccc caaccgcaug aacgggcacc accagcagaa cggcguggag      240

aacaugaugc uguucgaggu cgugaagaug ggcaagagcg ccaugcaguc cguggucgac      300

gacuggaucg agagcuacaa gcacgaccgg gacaucgccc ugcucgaccu gaucaacuuc      360

uucauccagu gcuccgggug caagggcgug gugaccgccg agauguuccg ccacaugcag      420

aacagcgaga ucauccggaa gaugaccgag gaguucgacg aggacuccgg ggacuacccc      480

cugacgaugg ccggccccca guggaagaag uucaagagcu ccuucugcga guucaucggc      540

guccucgugc gccagugcca guacagcauc aucuacgacg aguacaugau ggacaccgug      600

aucucccugc ugaccgggcu cagcgacucc cagguccggg cguuccgcca caccagcacg      660

cuggccgcca ugaagcugau gaccgcccuc gugaacgugg cgcugaaccu guccaucaac      720

auggacaaca cccagcggca guacgaggcc gagcgcaaca agaugaucgg caagcgggcc      780

aacgagcgcc ucgagcugcu gcuccagaag cggaaggagc ugcaggagaa ccaggacgag      840

aucgagaaca ugaugaacgc caucuucaag ggggucuucg ugcaccgcua ccgggacgcc      900

aucgcggaga uccgcgccau cugcaucgag gagaucggca ucuggaugaa gauguacagc      960

gacgccuucc ugaacgacuc cuaccucaag uacguggggu ggaccaugca cgacaagcag     1020

ggcgaggucc ggcugaagug ccugacggcc cuccagggcc uguacuacaa caaggagcug     1080

aacagcaagc ucgagcuguu caccagccgc uucaaggacc ggaucguguc caugacccug     1140

gacaaggagu acgacguggc cguccaggcg aucaagcucc ugacccuggu gcuccagagc     1200

uccgaggagg ugcugacggc cgaggacugc gagaacgucu accaccuggu guacagcgcc     1260

caccgccccg uggccgucgc cgcgggggag uuccucuaca agaagcuguu cucccggcgc     1320

gacccggagg aggacggcau gaugaagcgg cgcgggcgcc agggccccaa cgccaaccug     1380

gugaagaccc ucgucuucuu cuuccuggag agcgagcugc acgagcacgc cgccuaccuc     1440

guggacucca ugugggacug cgccaccgag cugcugaagg acugggagug caugaacagc     1500

cuccugcugg aggagccccu cuccggggag gaggcgcuga ccgaccggca ggagagcgcc     1560

cugaucgaga ucaugcugug cacgauccgc caggccgccg agugccaccc gcccgugggc     1620

cggggcaccg ggaagcgcgu ccucaccgcg aaggagaaga agacccagcu ggacgaccgg     1680

acgaagauca ccgagcuguu cgccguggcc cucccccagc ugcuggccaa guacuccgug     1740

gacgccgaga aggucaccaa ccuccugcag cugccccagu acuucgaccu cgagaucuac     1800

accacgggcc gccuggagaa gcaccuggac gcgcuccugc ggcagauccg caacaucgug     1860

gagaagcaca ccgacaccga cgugcuggag gccugcagca agaccuacca cgcccucugc     1920

aacgaggagu ucacgaucuu caaccggguc gacaucuccc gcagccagcu gaucgacgag     1980

cuggccgaca aguucaaccg gcuccuggag gacuuccugc aggaggggga ggagcccgac     2040

gaggacgacg ccuaccaggu gcucuccacc cugaagcgca ucaccgcguu ccacaacgcc     2100

cacgaccuga gcaaguggga ccucuucgcc ugcaacuaca agcugcugaa gaccggcauc     2160

gagaacgggg acaugccgga gcagaucgug auccacgccc uccagugcac gcacuacguc     2220

auccuguggc agcuggccaa gaucaccgag uccagcucca ccaaggagga ccuccugcgg     2280

cugaagaagc agaugcgcgu guucugccag aucugccagc acuaccucac caacgugaac     2340

accacgguca aggagcaggc guucaccauc cugugcgaca uccugaugau cuucagccac     2400

cagaucauga gcggcggccg ggacaugcuc gagccccugg uguacacccc cgacuccagc     2460

cugcaguccg agcuccugag cuucauccug gaccacgugu ucaucgagca ggacgacgac     2520

aacaacuccg ccgacgggca gcaggaggac gaggccagca agaucgaggc ccuccacaag     2580

cgccggaacc ugcuggcggc cuucugcaag cucaucgucu acaccguggu ggagaugaac     2640

acggccgccg acaucuucaa gcaguacaug aaguacuaca acgacuacgg cgacaucauc     2700

aaggagacca uguccaagac ccgccagauc gacaagaucc agugcgccaa gacccugauc     2760

cugagccucc agcagcuguu caacgagaug auccaggaga acggguacaa cuucgaccgg     2820

uccagcucca cguucagcgg caucaaggag cuggcgcgcc gcuucgcccu caccuucggc     2880

cuggaccagc ugaagacccg ggaggccauc gccaugcucc acaaggacgg gaucgaguuc     2940

gccuucaagg agcccaaccc gcagggcgag ucccacccgc cccugaaccu ggcguuccuc     3000

gacauccuga gcgaguucuc cagcaagcug cuccgccagg acaagcggac cgucuacgug     3060

uaccuggaga aguucaugac guuccagaug ucccugcgcc gggaggacgu guggcucccc     3120

cugaugagcu accgcaacag ccugcucgcc gggggcgacg acgacaccau guccgucauc     3180

agcgggaucu ccagccgggg cuccaccgug cgcagcaaga aguccaagcc cagcaccggc     3240

aagcggaagg uggucgaggg gaugcagcug ucccugacgg aggagagcuc cagcuccgac     3300

agcauguggc ucucccgcga gcagacccug cacacccccg ugaugaugca gacgccccag     3360

cugaccagca ccaucaugcg ggagcccaag cgccuccggc cggaggacuc cuucaugagc     3420

guguacccca ugcagaccga gcaccaccag acgccccugg acuacaacac ccaggucacc     3480

uggaugcugg cccagcgcca gcaggaggag gcccggcagc agcaggagcg cgccgcgaug     3540

uccuacguga agcuccggac caaccugcag cacgccaucc gccggggcac cagccugaug     3600

gaggacgacg aggagccgau cguggaggac gucaugauga gcuccgaggg gcgcaucgag     3660

gaccucaacg agggcaugga cuucgacacg auggacaucg accugccgcc cagcaagaac     3720

cggcgcgagc gcaccgagcu gaagcccgac uucuucgacc ccgccuccau cauggacgag     3780

agcgugcucg ggguguccau guucuga                                         3807


<210>  3509
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       STAG2__Homo_sapiens__CCDS43990.1

<400>  3509
augaucgccg cccccgagau ccccaccgac uucaaccucc uccaggaguc cgagacccac       60

uucuccuccg acaccgacuu cgaggacauc gagggcaaga accagaagca gggcaagggc      120

aagaccugca agaagggcaa gaagggcccc gccgagaagg gcaagggcgg caacggcggc      180

ggcaagcccc ccuccggccc caaccgcaug aacggccacc accagcagaa cggcgucgag      240

aacaugaugc ucuucgaggu cgucaagaug ggcaaguccg ccaugcaguc cgucgucgac      300

gacuggaucg aguccuacaa gcacgaccgc gacaucgccc uccucgaccu caucaacuuc      360

uucauccagu gcuccggcug caagggcguc gucaccgccg agauguuccg ccacaugcag      420

aacuccgaga ucauccgcaa gaugaccgag gaguucgacg aggacuccgg cgacuacccc      480

cucaccaugg ccggccccca guggaagaag uucaaguccu ccuucugcga guucaucggc      540

guccucgucc gccagugcca guacuccauc aucuacgacg aguacaugau ggacaccguc      600

aucucccucc ucaccggccu cuccgacucc cagguccgcg ccuuccgcca caccuccacc      660

cucgccgcca ugaagcucau gaccgcccuc gucaacgucg cccucaaccu cuccaucaac      720

auggacaaca cccagcgcca guacgaggcc gagcgcaaca agaugaucgg caagcgcgcc      780

aacgagcgcc ucgagcuccu ccuccagaag cgcaaggagc uccaggagaa ccaggacgag      840

aucgagaaca ugaugaacgc caucuucaag ggcgucuucg uccaccgcua ccgcgacgcc      900

aucgccgaga uccgcgccau cugcaucgag gagaucggca ucuggaugaa gauguacucc      960

gacgccuucc ucaacgacuc cuaccucaag uacgucggcu ggaccaugca cgacaagcag     1020

ggcgaggucc gccucaagug ccucaccgcc cuccagggcc ucuacuacaa caaggagcuc     1080

aacuccaagc ucgagcucuu caccucccgc uucaaggacc gcaucgucuc caugacccuc     1140

gacaaggagu acgacgucgc cguccaggcc aucaagcucc ucacccucgu ccuccagucc     1200

uccgaggagg uccucaccgc cgaggacugc gagaacgucu accaccucgu cuacuccgcc     1260

caccgccccg ucgccgucgc cgccggcgag uuccucuaca agaagcucuu cucccgccgc     1320

gaccccgagg aggacggcau gaugaagcgc cgcggccgcc agggccccaa cgccaaccuc     1380

gucaagaccc ucgucuucuu cuuccucgag uccgagcucc acgagcacgc cgccuaccuc     1440

gucgacucca ugugggacug cgccaccgag cuccucaagg acugggagug caugaacucc     1500

cuccuccucg aggagccccu cuccggcgag gaggcccuca ccgaccgcca ggaguccgcc     1560

cucaucgaga ucaugcucug caccauccgc caggccgccg agugccaccc ccccgucggc     1620

cgcggcaccg gcaagcgcgu ccucaccgcc aaggagaaga agacccagcu cgacgaccgc     1680

accaagauca ccgagcucuu cgccgucgcc cucccccagc uccucgccaa guacuccguc     1740

gacgccgaga aggucaccaa ccuccuccag cucccccagu acuucgaccu cgagaucuac     1800

accaccggcc gccucgagaa gcaccucgac gcccuccucc gccagauccg caacaucguc     1860

gagaagcaca ccgacaccga cguccucgag gccugcucca agaccuacca cgcccucugc     1920

aacgaggagu ucaccaucuu caaccgcguc gacaucuccc gcucccagcu caucgacgag     1980

cucgccgaca aguucaaccg ccuccucgag gacuuccucc aggagggcga ggagcccgac     2040

gaggacgacg ccuaccaggu ccucuccacc cucaagcgca ucaccgccuu ccacaacgcc     2100

cacgaccucu ccaaguggga ccucuucgcc ugcaacuaca agcuccucaa gaccggcauc     2160

gagaacggcg acaugcccga gcagaucguc auccacgccc uccagugcac ccacuacguc     2220

auccucuggc agcucgccaa gaucaccgag uccuccucca ccaaggagga ccuccuccgc     2280

cucaagaagc agaugcgcgu cuucugccag aucugccagc acuaccucac caacgucaac     2340

accaccguca aggagcaggc cuucaccauc cucugcgaca uccucaugau cuucucccac     2400

cagaucaugu ccggcggccg cgacaugcuc gagccccucg ucuacacccc cgacuccucc     2460

cuccaguccg agcuccucuc cuucauccuc gaccacgucu ucaucgagca ggacgacgac     2520

aacaacuccg ccgacggcca gcaggaggac gaggccucca agaucgaggc ccuccacaag     2580

cgccgcaacc uccucgccgc cuucugcaag cucaucgucu acaccgucgu cgagaugaac     2640

accgccgccg acaucuucaa gcaguacaug aaguacuaca acgacuacgg cgacaucauc     2700

aaggagacca uguccaagac ccgccagauc gacaagaucc agugcgccaa gacccucauc     2760

cucucccucc agcagcucuu caacgagaug auccaggaga acggcuacaa cuucgaccgc     2820

uccuccucca ccuucuccgg caucaaggag cucgcccgcc gcuucgcccu caccuucggc     2880

cucgaccagc ucaagacccg cgaggccauc gccaugcucc acaaggacgg caucgaguuc     2940

gccuucaagg agcccaaccc ccagggcgag ucccaccccc cccucaaccu cgccuuccuc     3000

gacauccucu ccgaguucuc cuccaagcuc cuccgccagg acaagcgcac cgucuacguc     3060

uaccucgaga aguucaugac cuuccagaug ucccuccgcc gcgaggacgu cuggcucccc     3120

cucauguccu accgcaacuc ccuccucgcc ggcggcgacg acgacaccau guccgucauc     3180

uccggcaucu ccucccgcgg cuccaccguc cgcuccaaga aguccaagcc cuccaccggc     3240

aagcgcaagg ucgucgaggg caugcagcuc ucccucaccg aggaguccuc cuccuccgac     3300

uccauguggc ucucccgcga gcagacccuc cacacccccg ucaugaugca gaccccccag     3360

cucaccucca ccaucaugcg cgagcccaag cgccuccgcc ccgaggacuc cuucaugucc     3420

gucuacccca ugcagaccga gcaccaccag accccccucg acuacaacac ccaggucacc     3480

uggaugcucg cccagcgcca gcaggaggag gcccgccagc agcaggagcg cgccgccaug     3540

uccuacguca agcuccgcac caaccuccag cacgccaucc gccgcggcac cucccucaug     3600

gaggacgacg aggagcccau cgucgaggac gucaugaugu ccuccgaggg ccgcaucgag     3660

gaccucaacg agggcaugga cuucgacacc auggacaucg accucccccc cuccaagaac     3720

cgccgcgagc gcaccgagcu caagcccgac uucuucgacc ccgccuccau cauggacgag     3780

uccguccucg gcgucuccau guucuga                                         3807


<210>  3510
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       STAG2__Homo_sapiens__CCDS43990.1

<400>  3510
augaucgccg cucccgagau uccuaccgac uucaaccugc uccaggaaag cgagacacac       60

uuuuccucug auacugacuu cgaagauaua gagggcaaga aucaaaaaca ggggaaggga      120

aaaacgugca agaaagguaa gaagggccca gcagaaaaag ggaagggagg caacgguggg      180

ggaaaaccgc ccucaggccc uaauagaaug aacggccauc accagcagaa ugggguggag      240

aacaugaugc uuuuugaggu cguuaagaug ggaaaaagug ccaugcaaag cgugguagac      300

gauuggaucg aauccuacaa gcaugacagg gauauugcgc uguuggacuu aaucaauuuc      360

uuuauucagu guucugguug caagggcgug gucaccgcug agauguuccg gcacaugcag      420

aacucggaaa ucauacgcaa aaugacagag gaguuugaug aagacucagg ggauuaucca      480

cugacuaugg ccggacccca guggaagaaa uucaagagca guuuuuguga guucaucggc      540

gugcuaguuc gacaaugcca guacuccauu aucuaugacg aauacaugau ggauaccgug      600

auuucucucc ugacaggucu uagcgacucc cagguccgug cauuuagaca uaccucaacu      660

cuggccgcua ugaaauugau gacagcacuc gugaauguag cccugaaccu gaguaucaau      720

auggacaaca cccagaggca auaugaggcu gaacggaaua agaugauagg gaaacgcgcc      780

aacgagagac ucgaguuacu gcuucagaag aggaaggaau ugcaggagaa ucaagaugaa      840

auugagaaca ugaugaacgc gaucuucaaa ggaguuuuug ugcaccggua ccgcgacgca      900

auugccgaaa uccgagcuau cuguauugag gagauaggca ucuggaugaa gauguauagc      960

gaugccuucc ugaaugacuc uuaccuaaaa uacgucggcu ggacgaugca cgauaagcag     1020

ggggaaguga gacucaaaug ccugacugca cuucagggac uguauuacaa caaggagcuc     1080

aauuccaagu uggaacuguu caccucaagg uuuaaagacc ggauugugag caugacauua     1140

gauaaggagu augacgucgc uguucaggcc aucaaacugc ucacucuugu gcugcaaagu     1200

ucugaagagg uauugaccgc ggaggauugu gaaaacgugu accaucuagu cuauuccgcc     1260

caccguccug uggcaguugc ugccggugag uuccuguaca agaaacucuu uagccgcaga     1320

gacccagaag aggauggcau gaugaagagg cgggggcgac agggacccaa ugcuaaccug     1380

gugaagacac uugucuucuu uuuccuggag ucggaauugc augagcacgc cgcauaucuc     1440

guggacucua ugugggacug cgccaccgaa cuguuaaaag auugggagug uaugaacucc     1500

cugcuacucg aagaaccucu gucaggcgag gaagcucuua cggaccgcca ggagagugcg     1560

uugauagaaa uuaugcugug cacuaucaga caggcagccg agugucaccc accgguaggu     1620

agggggacag gcaagcgggu ucucaccgcu aaagaaaaga aaacucaacu ggaugaccgc     1680

acaaagauca ccgagcuuuu ugccguggca cugccccagu ugcucgccaa guacagcguc     1740

gaugcugaga aagugacgaa ucuguuacag cugccucagu acuucgaccu agaaauuuau     1800

accacaggaa gacucgagaa gcaucuggau gcccuuuuga ggcaaauccg uaauauuguc     1860

gaaaaacaca cugacaccga ugugcuggag gcaugcucca agacauacca ugcgcucugc     1920

aacgaagagu uuacuauauu caaucggguu gacaucucuc gaagccagcu gauugaugag     1980

uuagcugaca aauuuaacag acugcuugaa gauuucuugc aggagggcga ggagccagac     2040

gaggacgaug ccuaucaggu gcucucaacc cugaagagga ucacagcauu ucacaaugcc     2100

caugaccuaa guaaauggga ucuguucgcu uguaacuaca agcuccugaa gaccgggauc     2160

gaaaauggag acaugcccga gcaaauugua auacacgccc uucagugcac ucacuauguc     2220

aucuuguggc agcuggcaaa aauuacggaa uccagcucua caaaggagga uuuacuccgc     2280

cugaaaaagc aaaugcgggu guucugucag aucugccagc auuaccuuac caacguuaac     2340

acuaccguga aagaacaggc uuuuacaauu cugugugaca ucuugaugau auucucacac     2400

caaaucauga gugguggcag agauaugcuc gagccucugg ucuauacccc agacagcucc     2460

cuacagucug agcugcucuc guuuauucug gaucaugugu ucaucgaaca ggacgaugac     2520

aauaacagcg ccgaugggca gcaagaggac gaagcgucca agauugaggc ccuucacaag     2580

aggcgcaauu ugcuggcugc auuuugcaaa uuaaucguau acacuguggu ugaaaugaac     2640

acagccgcug acauauucaa gcaguacaug aaauauuaca augauuaugg agacauuauc     2700

aaggagacga ugucaaaaac ccgacagauu gauaagaucc agugugccaa gacucucaua     2760

cugagucuuc aacagcuguu uaacgagaug auccaggaaa auggcuacaa cuucgaccgg     2820

ucuagcucca cauuuucagg uauuaaagag cuagcacgua gauucgcgcu caccuuuggg     2880

cuggaucaau ugaagacaag ggaagccauc gcuaugcugc acaaagacgg cauugaguuc     2940

gccuuuaagg aacccaaucc gcagggagag agccauccuc ccuuaaaccu cgcauuccug     3000

gauauccuuu cugaguucuc caguaaacug uugcgccagg acaagcggac ugucuaugug     3060

uaccucgaaa aguuuaugac cuuccagaug agccugagaa gggaggaugu guggcuacca     3120

cugaugucuu aucgaaauuc ccuucucgcu ggcggggacg augacacgau gucagucaua     3180

aguggaauua gcucgcgcgg uuccaccguu cggucuaaaa agagcaaacc uucaacaggc     3240

aagagaaaag ugguggaagg gaugcaacug aguuugacug aggaguccuc uagcuccgac     3300

ucaauguggc ugagcaggga acagaccuua cacacacccg uaaugaugca gacuccacag     3360

cucaccagua cgaucaugcg ugagcccaag cgccugcggc cugaagauuc uuuuaugucc     3420

gucuacccaa ugcaaacaga gcaucaccag accccgcuug acuacaacac ucaggugaca     3480

uggaugcugg cccagagaca acaggaagag gcaaggcagc agcaagagcg agccgcuaug     3540

agcuauguua aauugcggac caaucuccag caugcgaucc gcagaggaac uucgcugaug     3600

gaagaugacg aggaacccau uguggaggau gucaugaugu caucugaagg caggaucgag     3660

gaccuaaacg aggguaugga uuucgacacc auggauauug accugccucc aaguaagaau     3720

cggcgagaaa gaacagagcu uaagcccgac uuuuucgauc cugccuccau aauggaugaa     3780

agcgugcucg ggguuucuau guuuuga                                         3807


<210>  3511
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       STAG2__Homo_sapiens__CCDS43990.1

<400>  3511
augaucgccg cccccgagau ccccaccgac uucaaccugc ugcaggagag cgagacccac       60

uucagcagcg acaccgacuu cgaggacauc gagggcaaga accagaagca gggcaagggc      120

aagaccugca agaagggcaa gaagggcccc gccgagaagg gcaagggcgg caacggcggc      180

ggcaagcccc ccagcggccc caacagaaug aacggccacc accagcagaa cggcguggag      240

aacaugaugc uguucgaggu ggugaagaug ggcaagagcg ccaugcagag cgugguggac      300

gacuggaucg agagcuacaa gcacgacaga gacaucgccc ugcuggaccu gaucaacuuc      360

uucauccagu gcagcggcug caagggcgug gugaccgccg agauguucag acacaugcag      420

aacagcgaga ucaucagaaa gaugaccgag gaguucgacg aggacagcgg cgacuacccc      480

cugaccaugg ccggccccca guggaagaag uucaagagca gcuucugcga guucaucggc      540

gugcugguga gacagugcca guacagcauc aucuacgacg aguacaugau ggacaccgug      600

aucagccugc ugaccggccu gagcgacagc caggugagag ccuucagaca caccagcacc      660

cuggccgcca ugaagcugau gaccgcccug gugaacgugg cccugaaccu gagcaucaac      720

auggacaaca cccagagaca guacgaggcc gagagaaaca agaugaucgg caagagagcc      780

aacgagagac uggagcugcu gcugcagaag agaaaggagc ugcaggagaa ccaggacgag      840

aucgagaaca ugaugaacgc caucuucaag ggcguguucg ugcacagaua cagagacgcc      900

aucgccgaga ucagagccau cugcaucgag gagaucggca ucuggaugaa gauguacagc      960

gacgccuucc ugaacgacag cuaccugaag uacgugggcu ggaccaugca cgacaagcag     1020

ggcgagguga gacugaagug ccugaccgcc cugcagggcc uguacuacaa caaggagcug     1080

aacagcaagc uggagcuguu caccagcaga uucaaggaca gaaucgugag caugacccug     1140

gacaaggagu acgacguggc cgugcaggcc aucaagcugc ugacccuggu gcugcagagc     1200

agcgaggagg ugcugaccgc cgaggacugc gagaacgugu accaccuggu guacagcgcc     1260

cacagacccg uggccguggc cgccggcgag uuccuguaca agaagcuguu cagcagaaga     1320

gaccccgagg aggacggcau gaugaagaga agaggcagac agggccccaa cgccaaccug     1380

gugaagaccc ugguguucuu cuuccuggag agcgagcugc acgagcacgc cgccuaccug     1440

guggacagca ugugggacug cgccaccgag cugcugaagg acugggagug caugaacagc     1500

cugcugcugg aggagccccu gagcggcgag gaggcccuga ccgacagaca ggagagcgcc     1560

cugaucgaga ucaugcugug caccaucaga caggccgccg agugccaccc ccccgugggc     1620

agaggcaccg gcaagagagu gcugaccgcc aaggagaaga agacccagcu ggacgacaga     1680

accaagauca ccgagcuguu cgccguggcc cugccccagc ugcuggccaa guacagcgug     1740

gacgccgaga aggugaccaa ccugcugcag cugccccagu acuucgaccu ggagaucuac     1800

accaccggca gacuggagaa gcaccuggac gcccugcuga gacagaucag aaacaucgug     1860

gagaagcaca ccgacaccga cgugcuggag gccugcagca agaccuacca cgcccugugc     1920

aacgaggagu ucaccaucuu caacagagug gacaucagca gaagccagcu gaucgacgag     1980

cuggccgaca aguucaacag acugcuggag gacuuccugc aggagggcga ggagcccgac     2040

gaggacgacg ccuaccaggu gcugagcacc cugaagagaa ucaccgccuu ccacaacgcc     2100

cacgaccuga gcaaguggga ccuguucgcc ugcaacuaca agcugcugaa gaccggcauc     2160

gagaacggcg acaugcccga gcagaucgug auccacgccc ugcagugcac ccacuacgug     2220

auccuguggc agcuggccaa gaucaccgag agcagcagca ccaaggagga ccugcugaga     2280

cugaagaagc agaugagagu guucugccag aucugccagc acuaccugac caacgugaac     2340

accaccguga aggagcaggc cuucaccauc cugugcgaca uccugaugau cuucagccac     2400

cagaucauga gcggcggcag agacaugcug gagccccugg uguacacccc cgacagcagc     2460

cugcagagcg agcugcugag cuucauccug gaccacgugu ucaucgagca ggacgacgac     2520

aacaacagcg ccgacggcca gcaggaggac gaggccagca agaucgaggc ccugcacaag     2580

agaagaaacc ugcuggccgc cuucugcaag cugaucgugu acaccguggu ggagaugaac     2640

accgccgccg acaucuucaa gcaguacaug aaguacuaca acgacuacgg cgacaucauc     2700

aaggagacca ugagcaagac cagacagauc gacaagaucc agugcgccaa gacccugauc     2760

cugagccugc agcagcuguu caacgagaug auccaggaga acggcuacaa cuucgacaga     2820

agcagcagca ccuucagcgg caucaaggag cuggccagaa gauucgcccu gaccuucggc     2880

cuggaccagc ugaagaccag agaggccauc gccaugcugc acaaggacgg caucgaguuc     2940

gccuucaagg agcccaaccc ccagggcgag agccaccccc cccugaaccu ggccuuccug     3000

gacauccuga gcgaguucag cagcaagcug cugagacagg acaagagaac cguguacgug     3060

uaccuggaga aguucaugac cuuccagaug agccugagaa gagaggacgu guggcugccc     3120

cugaugagcu acagaaacag ccugcuggcc ggcggcgacg acgacaccau gagcgugauc     3180

agcggcauca gcagcagagg cagcaccgug agaagcaaga agagcaagcc cagcaccggc     3240

aagagaaagg ugguggaggg caugcagcug agccugaccg aggagagcag cagcagcgac     3300

agcauguggc ugagcagaga gcagacccug cacacccccg ugaugaugca gaccccccag     3360

cugaccagca ccaucaugag agagcccaag agacugagac ccgaggacag cuucaugagc     3420

guguacccca ugcagaccga gcaccaccag accccccugg acuacaacac ccaggugacc     3480

uggaugcugg cccagagaca gcaggaggag gccagacagc agcaggagag agccgccaug     3540

agcuacguga agcugagaac caaccugcag cacgccauca gaagaggcac cagccugaug     3600

gaggacgacg aggagcccau cguggaggac gugaugauga gcagcgaggg cagaaucgag     3660

gaccugaacg agggcaugga cuucgacacc auggacaucg accugccccc cagcaagaac     3720

agaagagaga gaaccgagcu gaagcccgac uucuucgacc ccgccagcau cauggacgag     3780

agcgugcugg gcgugagcau guucuga                                         3807


<210>  3512
<211>  3807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       STAG2__Homo_sapiens__CCDS43990.1

<400>  3512
augaucgccg cucccgagau uccuaccgac uucaaccugc uccaggaaag cgagacacac       60

uuuuccucug auacggacuu cgaagauauc gagggcaaga aucaaaaaca ggggaaggga      120

aaaaccugca agaaaggcaa gaaggggccg gccgaaaaag gaaagggcgg gaacggaggc      180

ggcaaacccc cuagcgggcc caauagaaug aacggacauc accagcagaa uggcguggag      240

aacaugaugc uguuugaggu cguuaagaug gggaaauccg cgaugcaauc ugugguggac      300

gauuggauug aaagcuacaa gcaugaccgg gauaucgccc uucuggaccu cauuaauuuc      360

uuuauccagu guuccggaug caagggcguc gugacagcug agauguuccg ccacaugcag      420

aacucugaaa ucauuagaaa aaugaccgag gaguuugaug aagacagcgg ggauuauccu      480

cugacaaugg ccggacccca guggaagaaa uucaagucca gcuuuuguga guucaucggc      540

guucuugugc ggcaaugcca guacucuauu aucuaugacg aauacaugau ggauaccguc      600

auuucccugc ucacaggccu gagcgacucu caggugcgcg cuuuuagaca uaccuccacg      660

cuggccgcua ugaaacucau gaccgcccug guuaaugugg cgcuuaaccu gagcaucaau      720

auggacaaca cacagcggca auaugaggcc gaacgcaaua agaugauugg gaaaagagcu      780

aacgagcggc ucgagcugcu ucugcagaag cgcaaggaac uccaggagaa ucaagaugaa      840

aucgagaaca ugaugaacgc caucuucaaa ggagucuuug ugcacagaua ccgggacgcu      900

auugccgaaa uccgcgcgau uuguaucgag gagauuggca ucuggaugaa gauguauucu      960

gaugccuucc ugaaugacuc cuaccugaaa uacguggggu ggaccaugca cgauaagcag     1020

ggagaaguca gacucaaaug ccugacagcc cuucagggcc uguauuacaa caaggagcuc     1080

aauagcaagc uggaacuuuu caccucccgg uuuaaagacc gcaucguuuc uaugacgcug     1140

gauaaggagu augacguggc ugugcaggcu auuaaacucc ugacacuggu ccuccaaagc     1200

uccgaagagg ugcugaccgc cgaggauugu gaaaacguuu accaucuugu guauagcgcc     1260

cacagaccug ucgcuguggc ggccggggag uuccuguaca agaaacucuu uucucggaga     1320

gacccggaag aggauggaau gaugaagcgc cggggcagac agggccccaa ugcuaaccug     1380

guuaagacac uuguguucuu uuuccuggag uccgaacucc augagcacgc cgccuaucug     1440

gucgacagca ugugggacug cgcuaccgaa cugcucaaag auugggagug uaugaauagc     1500

cugcuucugg aagaaccucu cagcggggag gaagcccuga ccgaccgcca ggaguccgcg     1560

cugaucgaaa uuaugcuuug cacaauccgg caggcugccg agugucaucc cccuguggga     1620

agaggcacgg ggaagcgcgu ccucaccgcc aaagaaaaga aaacacaacu ggaugaccgg     1680

accaagauua cagagcuguu ugcuguggcc cucccccagc ugcuugcuaa guacucuguu     1740

gaugccgaga aagugaccaa ccugcuccag cugccgcagu acuucgaccu ggaaaucuau     1800

acgacaggaa gacuugagaa gcaccucgau gcgcugcugc gccaaauccg gaauauuguc     1860

gaaaaacaca ccgacaccga ugugcucgag gccugcagca agacauacca ugcucugugc     1920

aacgaagagu uuaccaucuu caauagaguu gacauuuccc gcagccagcu uaucgaugag     1980

cuggccgaca aauuuaaccg gcuccuggaa gauuuccugc aggagggcga ggagccugac     2040

gaggacgaug cuuaucaggu gcuuucuaca cucaagagaa uuacggccuu ucacaaugcg     2100

caugaccugu ccaaauggga ucuguucgcc uguaacuaca agcuccugaa gaccgggauc     2160

gaaaauggcg acaugcccga gcaaauuguc auccacgccc uucagugcac acacuaugug     2220

auccuguggc agcucgcuaa aauuaccgaa ucuucuucca caaaggagga ucugcugcgg     2280

cuuaaaaagc aaaugcgcgu guucugucag aucugccagc auuaccucac caacguuaac     2340

acgaccguca aagaacaggc uuuuacaauu cugugugaca uccugaugau uuucagccac     2400

caaaucaugu ccggaggcag agauaugcuc gagccucugg uguauacccc cgacucuagc     2460

cuucaguccg agcugcucuc uuuuauccug gaucaugugu ucauugaaca ggacgaugac     2520

aauaacagcg ccgaugggca gcaagaggac gaagccucca agaucgaggc ucugcacaag     2580

cggagaaauc uucuggcggc cuuuugcaaa cucauugucu acacaguggu ugaaaugaac     2640

accgcugccg acaucuucaa gcaguacaug aaauauuaca augauuaugg agacauuauc     2700

aaggagacga ugagcaaaac acgccagauc gauaagauuc agugugccaa gacccugauc     2760

cucucucugc aacagcuuuu uaacgagaug auucaggaaa auggcuacaa cuucgaccgg     2820

uccagcucua cauuuuccgg gaucaaagag cuggcuagac gcuucgcccu caccuuugga     2880

cuggaucaac ugaagaccag agaagcgauu gcuaugcuuc acaaagacgg caucgaguuc     2940

gccuuuaagg aacccaaucc ucagggggag agccauccgc cccugaaccu cgccuuccug     3000

gauauccucu cugaguucag cuccaaacug cuucggcagg acaagcgcac aguguauguc     3060

uaccuggaaa aguuuaugac guuccagaug agccucagac gggaggaugu guggcugccu     3120

cugaugucuu aucgcaauuc ccuucuggcu ggcggagacg augacaccau gagcguuauu     3180

uccggcaucu cuagcagagg guccacagug cggucuaaaa agagcaaacc cuccaccgga     3240

aagcgcaaag ucguggaagg caugcaacuc ucucugacag aggagagcuc cagcucugac     3300

uccauguggc ucagcagaga acagacccug cacacgccug uuaugaugca gacaccccag     3360

cuuaccucua ccauuaugcg ggagccgaag cgccugagac cugaagauuc cuuuaugagc     3420

guguacccca ugcaaacaga gcaucaccag accccucugg acuacaacac acaggucacg     3480

uggaugcucg cccagcggca acaggaagag gcgagacagc agcaagagcg cgcugccaug     3540

ucuuauguga aacugcggac caaucuucag caugccauca gacgcgggac aucccugaug     3600

gaagaugacg aggaacccau uguggaggau gucaugauga gcuccgaagg acggaucgag     3660

gaccucaacg agggcaugga uuucgacacc auggauauug accugccucc cagcaagaau     3720

agacgcgaac ggacagagcu caagccggac uuuuucgauc cugcuucuau cauggaugaa     3780

agcguucugg ggguguccau guuuuga                                         3807


<210>  3513
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  STAMP-1__Homo_sapiens__Q8NFT2

<400>  3513

Met Glu Ser Ile Ser Met Met Gly Ser Pro Lys Ser Leu Ser Glu Thr 
1               5                   10                  15      


Phe Leu Pro Asn Gly Ile Asn Gly Ile Lys Asp Ala Arg Lys Val Thr 
            20                  25                  30          


Val Gly Val Ile Gly Ser Gly Asp Phe Ala Lys Ser Leu Thr Ile Arg 
        35                  40                  45              


Leu Ile Arg Cys Gly Tyr His Val Val Ile Gly Ser Arg Asn Pro Lys 
    50                  55                  60                  


Phe Ala Ser Glu Phe Phe Pro His Val Val Asp Val Thr His His Glu 
65                  70                  75                  80  


Asp Ala Leu Thr Lys Thr Asn Ile Ile Phe Val Ala Ile His Arg Glu 
                85                  90                  95      


His Tyr Thr Ser Leu Trp Asp Leu Arg His Leu Leu Val Gly Lys Ile 
            100                 105                 110         


Leu Ile Asp Val Ser Asn Asn Met Arg Ile Asn Gln Tyr Pro Glu Ser 
        115                 120                 125             


Asn Ala Glu Tyr Leu Ala Ser Leu Phe Pro Asp Ser Leu Ile Val Lys 
    130                 135                 140                 


Gly Phe Asn Val Val Ser Ala Trp Ala Leu Gln Leu Gly Pro Lys Asp 
145                 150                 155                 160 


Ala Ser Arg Gln Val Tyr Ile Cys Ser Asn Asn Ile Gln Ala Arg Gln 
                165                 170                 175     


Gln Val Ile Glu Leu Ala Arg Gln Leu Asn Phe Ile Pro Ile Asp Leu 
            180                 185                 190         


Gly Ser Leu Ser Ser Ala Arg Glu Ile Glu Asn Leu Pro Leu Arg Leu 
        195                 200                 205             


Phe Thr Leu Trp Arg Gly Pro Val Val Val Ala Ile Ser Leu Ala Thr 
    210                 215                 220                 


Phe Phe Phe Leu Tyr Ser Phe Val Arg Asp Val Ile His Pro Tyr Ala 
225                 230                 235                 240 


Arg Asn Gln Gln Ser Asp Phe Tyr Lys Ile Pro Ile Glu Ile Val Asn 
                245                 250                 255     


Lys Thr Leu Pro Ile Val Ala Ile Thr Leu Leu Ser Leu Val Tyr Leu 
            260                 265                 270         


Ala Gly Leu Leu Ala Ala Ala Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr 
        275                 280                 285             


Arg Arg Phe Pro Pro Trp Leu Glu Thr Trp Leu Gln Cys Arg Lys Gln 
    290                 295                 300                 


Leu Gly Leu Leu Ser Phe Phe Phe Ala Met Val His Val Ala Tyr Ser 
305                 310                 315                 320 


Leu Cys Leu Pro Met Arg Arg Ser Glu Arg Tyr Leu Phe Leu Asn Met 
                325                 330                 335     


Ala Tyr Gln Gln Val His Ala Asn Ile Glu Asn Ser Trp Asn Glu Glu 
            340                 345                 350         


Glu Val Trp Arg Ile Glu Met Tyr Ile Ser Phe Gly Ile Met Ser Leu 
        355                 360                 365             


Gly Leu Leu Ser Leu Leu Ala Val Thr Ser Ile Pro Ser Val Ser Asn 
    370                 375                 380                 


Ala Leu Asn Trp Arg Glu Phe Ser Phe Ile Gln Ser Thr Leu Gly Tyr 
385                 390                 395                 400 


Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys 
                405                 410                 415     


Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe 
            420                 425                 430         


Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Gly Lys Ile Ile 
        435                 440                 445             


Leu Phe Leu Pro Cys Ile Ser Arg Lys Leu Lys Arg Ile Lys Lys Gly 
    450                 455                 460                 


Trp Glu Lys Ser Gln Phe Leu Glu Glu Gly Met Gly Gly Thr Ile Pro 
465                 470                 475                 480 


His Val Ser Pro Glu Arg Val Thr Val Met 
                485                 490 


<210>  3514
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3514
auggaaucaa ucucuaugau gggaagcccu aagagccuua gugaaacuuu uuuaccuaau       60

ggcauaaaug guaucaaaga ugcaaggaag gucacuguag gugugauugg aaguggagau      120

uuugccaaau ccuugaccau ucgacuuauu agaugcggcu aucauguggu cauaggaagu      180

agaaauccua aguuugcuuc ugaauuuuuu ccucaugugg uagaugucac ucaucaugaa      240

gaugcucuca caaaaacaaa uauaauauuu guugcuauac acagagaaca uuauaccucc      300

cugugggacc ugagacaucu gcuugugggu aaaauccuga uugaugugag caauaacaug      360

aggauaaacc aguacccaga auccaaugcu gaauauuugg cuucauuauu cccagauucu      420

uugauuguca aaggauuuaa uguugucuca gcuugggcac uucaguuagg accuaaggau      480

gccagccggc agguuuauau augcagcaac aauauucaag cgcgacaaca gguuauugaa      540

cuugcccgcc aguugaauuu cauucccauu gacuugggau ccuuaucauc agccagagag      600

auugaaaauu uaccccuacg acucuuuacu cucuggagag ggccaguggu gguagcuaua      660

agcuuggcca cauuuuuuuu ccuuuauucc uuugucagag augugauuca uccauaugcu      720

agaaaccaac agagugacuu uuacaaaauu ccuauagaga uugugaauaa aaccuuaccu      780

auaguugcca uuacuuugcu cucccuagua uaccucgcag gucuucuggc agcugcuuau      840

caacuuuauu acggcaccaa guauaggaga uuuccaccuu gguuggaaac cugguuacag      900

uguagaaaac agcuuggauu acuaaguuuu uucuucgcua ugguccaugu ugccuacagc      960

cucugcuuac cgaugagaag gucagagaga uauuuguuuc ucaacauggc uuaucagcag     1020

guucaugcaa auauugaaaa cucuuggaau gaggaagaag uuuggagaau ugaaauguau     1080

aucuccuuug gcauaaugag ccuuggcuua cuuucccucc uggcagucac uucuaucccu     1140

ucagugagca augcuuuaaa cuggagagaa uucaguuuua uucagucuac acuuggauau     1200

gucgcucugc ucauaaguac uuuccauguu uuaauuuaug gauggaaacg agcuuuugag     1260

gaagaguacu acagauuuua uacaccacca aacuuuguuc uugcucuugu uuugcccuca     1320

auuguaauuc uggguaagau uauuuuauuc cuuccaugua uaagccgaaa gcuaaaacga     1380

auuaaaaaag gcugggaaaa gagccaauuu cuggaagaag guaugggagg aacaauuccu     1440

caugucuccc cggagagggu cacaguaaug uga                                  1473


<210>  3515
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3515
auggagagca ucuccaugau gggcagcccc aagucccuga gcgagaccuu ccucccgaac       60

gggaucaacg gcaucaagga cgcccgcaag gugaccgucg gggugaucgg cuccggggac      120

uucgccaaga gccugacgau ccggcugauc cgcugcggcu accacguggu caucggcucc      180

cggaacccca aguucgcgag cgaguucuuc ccccacgugg uggacgucac ccaccacgag      240

gacgcccuca ccaagaccaa caucaucuuc guggccaucc accgcgagca cuacacgucc      300

cugugggacc ugcggcaccu ccuggugggg aagauccuga ucgacgucag caacaacaug      360

cgcaucaacc aguaccccga guccaacgcc gaguaccucg ccagccuguu cccggacucc      420

cugaucguga agggcuucaa cguggucagc gcgugggccc uccagcuggg gcccaaggac      480

gccucccgcc agguguacau cugcagcaac aacauccagg cccggcagca ggucaucgag      540

cuggcgcggc agcucaacuu cauccccauc gaccugggcu cccugagcuc cgcccgcgag      600

aucgagaacc ucccccugcg gcuguucacc cucuggcgcg ggccgguggu gguggccauc      660

agccuggcca ccuucuucuu ccuguacagc uucguccggg acgugaucca ccccuacgcc      720

cgcaaccagc aguccgacuu cuacaagauc cccaucgaga ucgugaacaa gacccucccc      780

aucgucgcga ucacgcugcu gagccucgug uaccuggccg gccugcucgc cgccgccuac      840

cagcuguacu acggcaccaa guaccggcgc uucccgcccu ggcuggagac cuggcuccag      900

ugccggaagc agcuggggcu gcucuccuuc uucuucgcga uggugcacgu cgccuacagc      960

cugugccugc ccaugcgccg guccgagcgc uaccucuucc ugaacauggc cuaccagcag     1020

guccacgcca acaucgagaa cagcuggaac gaggaggagg uguggcggau cgagauguac     1080

aucuccuucg gcaucaugag ccuggggcuc cugucccugc ucgccgugac cagcaucccc     1140

uccgugagca acgcgcugaa cuggcgcgag uucuccuuca uccagagcac gcugggcuac     1200

gucgcccucc ugaucuccac cuuccacgug cugaucuacg gcuggaagcg cgccuucgag     1260

gaggaguacu accgguucua caccccgccc aacuucgugc uggcccucgu ccugcccagc     1320

aucgugaucc uggggaagau cauccucuuc cugcccugca ucucccgcaa gcugaagcgg     1380

aucaagaagg gcugggagaa gucccaguuc cucgaggagg ggaugggcgg gaccaucccg     1440

cacgugagcc ccgagcgcgu cacggugaug uga                                  1473


<210>  3516
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3516
auggagucca ucuccaugau gggcuccccc aagucccucu ccgagaccuu ccuccccaac       60

ggcaucaacg gcaucaagga cgcccgcaag gucaccgucg gcgucaucgg cuccggcgac      120

uucgccaagu cccucaccau ccgccucauc cgcugcggcu accacgucgu caucggcucc      180

cgcaacccca aguucgccuc cgaguucuuc ccccacgucg ucgacgucac ccaccacgag      240

gacgcccuca ccaagaccaa caucaucuuc gucgccaucc accgcgagca cuacaccucc      300

cucugggacc uccgccaccu ccucgucggc aagauccuca ucgacgucuc caacaacaug      360

cgcaucaacc aguaccccga guccaacgcc gaguaccucg ccucccucuu ccccgacucc      420

cucaucguca agggcuucaa cgucgucucc gccugggccc uccagcucgg ccccaaggac      480

gccucccgcc aggucuacau cugcuccaac aacauccagg cccgccagca ggucaucgag      540

cucgcccgcc agcucaacuu cauccccauc gaccucggcu cccucuccuc cgcccgcgag      600

aucgagaacc ucccccuccg ccucuucacc cucuggcgcg gccccgucgu cgucgccauc      660

ucccucgcca ccuucuucuu ccucuacucc uucguccgcg acgucaucca ccccuacgcc      720

cgcaaccagc aguccgacuu cuacaagauc cccaucgaga ucgucaacaa gacccucccc      780

aucgucgcca ucacccuccu cucccucguc uaccucgccg gccuccucgc cgccgccuac      840

cagcucuacu acggcaccaa guaccgccgc uucccccccu ggcucgagac cuggcuccag      900

ugccgcaagc agcucggccu ccucuccuuc uucuucgcca ugguccacgu cgccuacucc      960

cucugccucc ccaugcgccg cuccgagcgc uaccucuucc ucaacauggc cuaccagcag     1020

guccacgcca acaucgagaa cuccuggaac gaggaggagg ucuggcgcau cgagauguac     1080

aucuccuucg gcaucauguc ccucggccuc cucucccucc ucgccgucac cuccaucccc     1140

uccgucucca acgcccucaa cuggcgcgag uucuccuuca uccaguccac ccucggcuac     1200

gucgcccucc ucaucuccac cuuccacguc cucaucuacg gcuggaagcg cgccuucgag     1260

gaggaguacu accgcuucua cacccccccc aacuucgucc ucgcccucgu ccuccccucc     1320

aucgucaucc ucggcaagau cauccucuuc cuccccugca ucucccgcaa gcucaagcgc     1380

aucaagaagg gcugggagaa gucccaguuc cucgaggagg gcaugggcgg caccaucccc     1440

cacgucuccc ccgagcgcgu caccgucaug uga                                  1473


<210>  3517
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3517
auggagagca ucuccaugau gggcucuccc aagucacuga gugaaaccuu ccucccuaac       60

gggauuaaug gaauaaaaga cgccagaaag gugacagucg guguuaucgg cagcggggau      120

uuugcuaaau cccuuacuau uaggcugauc cggugcggau accacguggu aauuggcucu      180

cgcaacccaa aguucgcauc ggaguuuuuc ccgcaugugg ucgacgugac gcaccaugaa      240

gaugccuuga ccaaaacaaa uaucauauuu guugcgaucc accgagagca uuauacuuca      300

uuaugggacc ugcgucaccu acucgugggu aagauucuga ucgaugucag caacaauaug      360

agaauuaacc aguaccccga aaguaaugcu gaguaucuug ccucccuguu cccugacucu      420

uugaucguga agggguuuaa cguaguuagc gcaugggccc uccaacuggg accaaaagau      480

gcuuccaggc aaguguacau auguucaaau aacauucagg cacggcagca ggucaucgag      540

cuggcccgcc agcucaauuu cauucccauc gacuuaggca gucugagcuc ugcuagagaa      600

aucgagaacc uuccuuugag gcuguuuacc cuauggcggg gcccaguggu ggucgccauu      660

ucccucgcga cauucuuuuu ccuguauuca uuuguucgcg augugauaca ccccuacgca      720

cgaaaucagc agagcgacuu cuauaagauc ccuauugaaa ucguaaacaa aacccuucca      780

auaguggcca uuacucuguu gagucucguc uaccuggcug gguuacuggc cgcagcuuac      840

caacucuauu acggaacaaa guauagaagg uucccgcccu ggcuugagac cuggcugcag      900

ugccggaaac aguugggucu acugagcuuu uucuuugcca uggugcaugu ugcguacucc      960

cucugucugc cuaugcgucg cagcgagaga uaucuuuucc ugaauauggc cuaccagcaa     1020

gugcacgcaa acaucgaaaa cucguggaau gaggaagagg ucuggaggau cgaaauguau     1080

auuucuuuug gcaucauguc cuuggggcuc cugucauuac uggcugugac gaguauucca     1140

agcguaucca acgcccuaaa uuggcgggag uucucuuuua uacagagcac ucucggauac     1200

guugcucugc uuaucucaac cuuccaugug uugauuuacg gcuggaagcg agccuuugag     1260

gaagaguauu accgcuucua uacacccccu aacuuugucc uggcacucgu gcugccaagu     1320

aucgucaucc uugguaagau uauacuguuc uugcccugca ucuccagaaa acucaagagg     1380

auuaaaaagg ggugggaaaa aucucaguuu cuggaggaag gaaugggcgg cacuaucccg     1440

cacgugucuc cugagcgggu uaccgugaug uga                                  1473


<210>  3518
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3518
auggagagca ucagcaugau gggcagcccc aagagccuga gcgagaccuu ccugcccaac       60

ggcaucaacg gcaucaagga cgccagaaag gugaccgugg gcgugaucgg cagcggcgac      120

uucgccaaga gccugaccau cagacugauc agaugcggcu accacguggu gaucggcagc      180

agaaacccca aguucgccag cgaguucuuc ccccacgugg uggacgugac ccaccacgag      240

gacgcccuga ccaagaccaa caucaucuuc guggccaucc acagagagca cuacaccagc      300

cugugggacc ugagacaccu gcuggugggc aagauccuga ucgacgugag caacaacaug      360

agaaucaacc aguaccccga gagcaacgcc gaguaccugg ccagccuguu ccccgacagc      420

cugaucguga agggcuucaa cguggugagc gccugggccc ugcagcuggg ccccaaggac      480

gccagcagac agguguacau cugcagcaac aacauccagg ccagacagca ggugaucgag      540

cuggccagac agcugaacuu cauccccauc gaccugggca gccugagcag cgccagagag      600

aucgagaacc ugccccugag acuguucacc cuguggagag gccccguggu gguggccauc      660

agccuggcca ccuucuucuu ccuguacagc uucgugagag acgugaucca ccccuacgcc      720

agaaaccagc agagcgacuu cuacaagauc cccaucgaga ucgugaacaa gacccugccc      780

aucguggcca ucacccugcu gagccuggug uaccuggccg gccugcuggc cgccgccuac      840

cagcuguacu acggcaccaa guacagaaga uucccccccu ggcuggagac cuggcugcag      900

ugcagaaagc agcugggccu gcugagcuuc uucuucgcca uggugcacgu ggccuacagc      960

cugugccugc ccaugagaag aagcgagaga uaccuguucc ugaacauggc cuaccagcag     1020

gugcacgcca acaucgagaa cagcuggaac gaggaggagg uguggagaau cgagauguac     1080

aucagcuucg gcaucaugag ccugggccug cugagccugc uggccgugac cagcaucccc     1140

agcgugagca acgcccugaa cuggagagag uucagcuuca uccagagcac ccugggcuac     1200

guggcccugc ugaucagcac cuuccacgug cugaucuacg gcuggaagag agccuucgag     1260

gaggaguacu acagauucua cacccccccc aacuucgugc uggcccuggu gcugcccagc     1320

aucgugaucc ugggcaagau cauccuguuc cugcccugca ucagcagaaa gcugaagaga     1380

aucaagaagg gcugggagaa gagccaguuc cuggaggagg gcaugggcgg caccaucccc     1440

cacgugagcc ccgagagagu gaccgugaug uga                                  1473


<210>  3519
<211>  1473
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       STAMP-1__Homo_sapiens__CCDS5615.1

<400>  3519
auggagagca ucuccaugau gggcucuccc aagagccugu ccgaaaccuu ccucccuaac       60

gggauuaaug gaaucaaaga cgccagaaag gugacagucg gcguuauugg gucuggagau      120

uuugcuaaaa gccugacgau ccggcuuauu cgcugcggcu accacguggu gaucgggucc      180

agaaacccga aguucgccuc ugaguuuuuc ccccaugucg uggacguuac ccaccaugaa      240

gaugcgcuga caaaaaccaa uaucauuuuu guggcuaucc accgggagca uuauacaagc      300

cucugggacc ugcgccaccu ucuggucgga aagauucuca ucgauguguc caacaauaug      360

agaauuaacc aguacccuga aagcaaugcc gaguaucugg ccucucuguu ccccgacucc      420

cucaucguua agggcuuuaa cguggucagc gcuugggccc ugcaacuugg cccuaaagau      480

gcuucucgcc agguguacau uuguuccaau aacauccagg cccggcagca agugaucgag      540

cuggcgagac agcucaauuu cauucccauc gaccugggga gccuuucuuc cgcccgggaa      600

auugagaacc ugccucuccg ccuguuuacc cuguggagag gaccggucgu uguggcuauc      660

agccucgcca cauucuuuuu ccuguauucc uuugugcggg augucauuca ccccuacgcu      720

cgcaaucagc agucugacuu cuauaagauc ccuaucgaaa uugugaacaa aacccuuccc      780

aucguugcca uuacgcugcu cagccuggug uaccuugcgg gccugcucgc cgcugccuac      840

caacuguauu acgggaccaa guauagacgg uucccucccu ggcuggagac auggcuccag      900

ugccgcaaac agcugggacu ucuguccuuu uucuuugcua ugguccaugu ggccuacagc      960

cucugucugc cgaugagacg gucugagaga uaucuuuucc ugaauauggc cuaccagcaa     1020

guucacgcua acaucgaaaa cuccuggaau gaggaagagg uguggcgcau ugaaauguau     1080

aucagcuuug gcaucauguc ucucgggcug cugagccucc uggcggucac cuccauuccu     1140

ucugugagca acgcccuuaa uuggcgggag uucuccuuua uccagagcac acugggauac     1200

gucgcucucc ugauuucuac cuuccaugug cugaucuacg gcuggaagag agccuuugag     1260

gaagaguauu accgcuucua uacgcccccu aacuuuguuc uugcccucgu gcugcccucc     1320

auugucaucc ugggcaagau uauccucuuc cugcccugca ucagccggaa acuuaagaga     1380

auuaaaaagg ggugggaaaa aucucaguuu cuggaggaag gaaugggcgg gacaaucccu     1440

cacguguccc cggagcgcgu uaccgugaug uga                                  1473


<210>  3520
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  STEAP-1__Homo_sapiens__A0A024RA63

<400>  3520

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Ile Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Asp Asn Asp Tyr Leu His Lys Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu Gln Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Ala 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Val 
65                  70                  75                  80  


Met Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Val His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Leu Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Thr Leu Ser Tyr Ala Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Val Asn 
                245                 250                 255     


Asn Ile 
        


<210>  3521
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  STEAP-1__Homo_sapiens__EAW93749

<400>  3521
auggaaagca gaaaagacau cacaaaccaa gaagaaauuu ggaaaaugaa gccuaggaga       60

aauuuagaag acaacgauua uuugcauaag gacacgggag agaccagcau gcuaaaaaga      120

ccugugcuuu ugcauuugca gcaaacagcc caugcugaug aauuugacug cccuucagaa      180

cuucagcacg cacaggaacu cuuuccacag uggcacuugc caauuaaaau agcugcuguu      240

auggcaucuc ugacuuuucu uuacacucuu cugagggaag uaauucaccc uuuagcaacu      300

ucccaucaac aauauuuuua uaaaauucca auccugguca ucaacaaagu cuugccaaug      360

guuuccauca cucucuuggc auugguuuac cuaccaggug ugauagcagc aauuguccaa      420

guucauaaug gaaccaagua uaagaaguuu ccacauuggu uggauaagug gauguuaaca      480

agaaagcagu uugggcuucu caguuuguuu uuugcuguac ugcaugcaau uuauacucug      540

ucuuacgcaa ugaggcgauc cuacagauac aaguugcuaa acugggcaua ucaacagguc      600

caacaaaaua aagaagaugc cuggauugag caugauguuu ggagaaugga gauuuaugug      660

ucucugggaa uugugggacu ggcaauacug gcucuguugg cugugacauc uauuccaucu      720

gugagugacu cuuugacaug gagagaauuu cacuauauuc agguaaauaa uauauaa         777


<210>  3522
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       STEAP-1__Homo_sapiens__EAW93749

<400>  3522
auggagagcc gcaaggacau caccaaccag gaggagaucu ggaagaugaa gccccggcgc       60

aaccuggagg acaacgacua ccuccacaag gacaccggcg agacguccau gcugaagcgg      120

ccggugcugc uccaccucca gcagaccgcc cacgccgacg aguucgacug ccccagcgag      180

cugcagcacg cgcaggagcu guucccccag uggcaccucc ccaucaagau cgccgccguc      240

auggccuccc ugaccuuccu guacacccug cugcgcgagg ugauccaccc gcucgccacg      300

agccaccagc aguacuucua caagaucccc auccugguga ucaacaaggu ccugcccaug      360

guguccauca cccuccuggc gcugguguac cuccccgggg ucaucgccgc caucguccag      420

gugcacaacg gcaccaagua caagaaguuc ccgcacuggc uggacaagug gaugcugacc      480

cggaagcagu ucgggcuccu gagccuguuc uucgccgugc uccacgcgau cuacacgcug      540

uccuacgcca ugcgccggag cuaccgcuac aagcugcuca acugggccua ccagcagguc      600

cagcagaaca aggaggacgc cuggaucgag cacgacgugu ggcggaugga gaucuacgug      660

ucccugggca ucguggggcu ggccauccuc gcgcugcugg ccgugaccag cauccccucc      720

gucagcgacu cccucaccug gcgcgaguuc cacuacaucc aggugaacaa caucuga         777


<210>  3523
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       STEAP-1__Homo_sapiens__EAW93749

<400>  3523
auggaguccc gcaaggacau caccaaccag gaggagaucu ggaagaugaa gccccgccgc       60

aaccucgagg acaacgacua ccuccacaag gacaccggcg agaccuccau gcucaagcgc      120

cccguccucc uccaccucca gcagaccgcc cacgccgacg aguucgacug ccccuccgag      180

cuccagcacg cccaggagcu cuucccccag uggcaccucc ccaucaagau cgccgccguc      240

auggccuccc ucaccuuccu cuacacccuc cuccgcgagg ucauccaccc ccucgccacc      300

ucccaccagc aguacuucua caagaucccc auccucguca ucaacaaggu ccuccccaug      360

gucuccauca cccuccucgc ccucgucuac cuccccggcg ucaucgccgc caucguccag      420

guccacaacg gcaccaagua caagaaguuc ccccacuggc ucgacaagug gaugcucacc      480

cgcaagcagu ucggccuccu cucccucuuc uucgccgucc uccacgccau cuacacccuc      540

uccuacgcca ugcgccgcuc cuaccgcuac aagcuccuca acugggccua ccagcagguc      600

cagcagaaca aggaggacgc cuggaucgag cacgacgucu ggcgcaugga gaucuacguc      660

ucccucggca ucgucggccu cgccauccuc gcccuccucg ccgucaccuc cauccccucc      720

gucuccgacu cccucaccug gcgcgaguuc cacuacaucc aggucaacaa caucuga         777


<210>  3524
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       STEAP-1__Homo_sapiens__EAW93749

<400>  3524
auggagagca gaaaggacau caccaaccag gaagagauuu ggaaaaugaa gcccaggcgg       60

aaucuggaag auaacgacua ccuccacaaa gauacaggcg agacuuccau gcuuaagcgc      120

ccugugcugu ugcauuuaca acagacggcc cacgcugacg aguucgauug cccaucugaa      180

cugcagcaug cacaggagcu auuuccgcaa uggcaccucc ccauaaaaau cgccgcgguc      240

auggcuucac ugaccuuccu uuauacacug uugcgagaag uuauucaucc ucucgccacc      300

agucaccagc aguacuuuua uaagauccca auucugguga ucaauaaggu acugcccaug      360

gugagcauaa cucucuuagc acuggucuac cuuccugggg ugaucgccgc uauuguucag      420

gugcacaacg gaacaaaaua uaagaaauuc ccacauuggu uggacaagug gaugcugacc      480

cguaaacaau uuggucuacu cucccuguuc uuugcagucc uucacgccau cuacacucug      540

ucuuaugcua ugagaagguc guaccgguac aaguugcuca auugggccua ucaacaggug      600

cagcagaaca aggaggaugc guggauugaa caugacguau ggcgcaugga gaucuacguu      660

ucacugggca uagugggguu agcaauucug gcccuccuug cugucacaag cauccccagu      720

guguccgauu cucugaccug gagagaguuc cacuauauuc aggugaauaa caucuga         777


<210>  3525
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       STEAP-1__Homo_sapiens__EAW93749

<400>  3525
auggagagca gaaaggacau caccaaccag gaggagaucu ggaagaugaa gcccagaaga       60

aaccuggagg acaacgacua ccugcacaag gacaccggcg agaccagcau gcugaagaga      120

cccgugcugc ugcaccugca gcagaccgcc cacgccgacg aguucgacug ccccagcgag      180

cugcagcacg cccaggagcu guucccccag uggcaccugc ccaucaagau cgccgccgug      240

auggccagcc ugaccuuccu guacacccug cugagagagg ugauccaccc ccuggccacc      300

agccaccagc aguacuucua caagaucccc auccugguga ucaacaaggu gcugcccaug      360

gugagcauca cccugcuggc ccugguguac cugcccggcg ugaucgccgc caucgugcag      420

gugcacaacg gcaccaagua caagaaguuc ccccacuggc uggacaagug gaugcugacc      480

agaaagcagu ucggccugcu gagccuguuc uucgccgugc ugcacgccau cuacacccug      540

agcuacgcca ugagaagaag cuacagauac aagcugcuga acugggccua ccagcaggug      600

cagcagaaca aggaggacgc cuggaucgag cacgacgugu ggagaaugga gaucuacgug      660

agccugggca ucgugggccu ggccauccug gcccugcugg ccgugaccag cauccccagc      720

gugagcgaca gccugaccug gagagaguuc cacuacaucc aggugaacaa caucuga         777


<210>  3526
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       STEAP-1__Homo_sapiens__EAW93749

<400>  3526
auggagagca gaaaggacau caccaaccag gaagagauuu ggaaaaugaa gccccggcgc       60

aaucuggaag auaacgacua ccuccacaaa gauacaggcg agacguccau gcugaagaga      120

ccugugcuuc ugcaucucca acagaccgcc cacgcugacg aguucgauug cccgucugaa      180

cugcagcaug cccaggagcu uuuuccccaa uggcaucugc cuaucaaaau ugcggcuguc      240

auggccagcc ucacauuccu guauacccug cuccgggaag uuauccaccc ccuggccaca      300

ucccaccagc aguacuuuua uaagauuccu auccuuguga ucaauaaggu gcugcccaug      360

gucucuauua cccuccuggc ucuuguguac cugccugggg uuaucgccgc uauugugcag      420

guccacaacg gaacaaaaua uaagaaauuc ccgcauuggc ucgacaagug gaugcugacc      480

cgcaaacaau uuggccugcu cagccuguuc uuugccgugc uucacgcgau cuacacgcug      540

uccuaugcca ugagacgguc uuaccgcuac aagcuccuga auugggcuua ucagcagguu      600

cagcaaaaca aggaggaugc cuggauugaa caugacgugu ggagaaugga gaucuacguc      660

agccuuggga uugugggacu ggcuauccuc gcccugcugg cggugaccuc cauccccagc      720

gucucugauu cccucacaug gcgggaguuc cacuauauuc agguuaauaa caucuga         777


<210>  3527
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  STEAP-1__Homo_sapiens__Q9UHE8

<400>  3527

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile 
65                  70                  75                  80  


Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys 
                245                 250                 255     


Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe 
            260                 265                 270         


Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro 
        275                 280                 285             


Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile Phe 
    290                 295                 300                 


Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile 
305                 310                 315                 320 


Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Cys 
                325                 330                 335     


Ser Gln Leu 
            


<210>  3528
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  STEAP-1__Homo_sapiens__AAD15620

<400>  3528
auggaaagca gaaaagacau cacaaaccaa gaagaacuuu ggaaaaugaa gccuaggaga       60

aauuuagaag aagacgauua uuugcauaag gacacgggag agaccagcau gcuaaaaaga      120

ccugugcuuu ugcauuugca ccaaacagcc caugcugaug aauuugacug cccuucagaa      180

cuucagcaca cacaggaacu cuuuccacag uggcacuugc caauuaaaau agcugcuauu      240

auagcaucuc ugacuuuucu uuacacucuu cugagggaag uaauucaccc uuuagcaacu      300

ucccaucaac aauauuuuua uaaaauucca auccugguca ucaacaaagu cuugccaaug      360

guuuccauca cucucuuggc auugguuuac cugccaggug ugauagcagc aauuguccaa      420

cuucauaaug gaaccaagua uaagaaguuu ccacauuggu uggauaagug gauguuaaca      480

agaaagcagu uugggcuucu caguuucuuu uuugcuguac ugcaugcaau uuauagucug      540

ucuuacccaa ugaggcgauc cuacagauac aaguugcuaa acugggcaua ucaacagguc      600

caacaaaaua aagaagaugc cuggauugag caugauguuu ggagaaugga gauuuaugug      660

ucucugggaa uugugggauu ggcaauacug gcucuguugg cugugacauc uauuccaucu      720

gugagugacu cuuugacaug gagagaauuu cacuauauuc agagcaagcu aggaauuguu      780

ucccuucuac ugggcacaau acacgcauug auuuuugccu ggaauaagug gauagauaua      840

aaacaauuug uaugguauac accuccaacu uuuaugauag cuguuuuccu uccaauuguu      900

guccugauau uuaaaagcau acuauuccug ccaugcuuga ggaagaagau acugaagauu      960

agacaugguu gggaagacgu caccaaaauu aacaaaacug agauauguuc ccaguuguag     1020


<210>  3529
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       STEAP-1__Homo_sapiens__AAD15620

<400>  3529
auggagagcc gcaaggacau caccaaccag gaggagcugu ggaagaugaa gccccggcgc       60

aaccucgagg aggacgacua ccugcacaag gacaccggcg agacguccau gcugaagcgg      120

ccggugcucc ugcaccucca ccagaccgcc cacgccgacg aguucgacug ccccagcgag      180

cugcagcaca cccaggagcu guucccccag uggcaccucc ccaucaagau cgcggccauc      240

aucgccuccc ugaccuuccu guacacgcug cuccgcgagg ucauccaccc gcuggccacc      300

agccaccagc aguacuucua caagaucccc auccugguga ucaacaaggu gcuccccaug      360

gucuccauca cccugcuggc ccucguguac cugcccgggg ugaucgcggc caucguccag      420

cugcacaacg gcaccaagua caagaaguuc ccgcacuggc ucgacaagug gaugcugacg      480

cggaagcagu ucgggcugcu cagcuucuuc uucgccgugc ugcacgccau cuacucccug      540

agcuacccca ugcgccgguc cuaccgcuac aagcuccuga acugggcgua ccagcagguc      600

cagcagaaca aggaggacgc cuggaucgag cacgacgugu ggcggaugga gaucuacgug      660

agccugggca ucguggggcu cgccauccug gcccugcucg ccgucaccuc cauccccagc      720

guguccgaca gccugaccug gcgcgaguuc cacuacaucc aguccaagcu gggcaucgug      780

agccuccugc ugggcaccau ccacgcgcuc aucuucgccu ggaacaagug gaucgacauc      840

aagcaguucg ucugguacac gcccccgacc uucaugaucg ccguguuccu gcccaucgug      900

guccugaucu ucaaguccau ccucuuccug cccugccugc ggaagaagau ccucaagauc      960

cgccacgggu gggaggacgu gaccaagauc aacaagaccg agaucugcag ccagcuguga     1020


<210>  3530
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       STEAP-1__Homo_sapiens__AAD15620

<400>  3530
auggaguccc gcaaggacau caccaaccag gaggagcucu ggaagaugaa gccccgccgc       60

aaccucgagg aggacgacua ccuccacaag gacaccggcg agaccuccau gcucaagcgc      120

cccguccucc uccaccucca ccagaccgcc cacgccgacg aguucgacug ccccuccgag      180

cuccagcaca cccaggagcu cuucccccag uggcaccucc ccaucaagau cgccgccauc      240

aucgccuccc ucaccuuccu cuacacccuc cuccgcgagg ucauccaccc ccucgccacc      300

ucccaccagc aguacuucua caagaucccc auccucguca ucaacaaggu ccuccccaug      360

gucuccauca cccuccucgc ccucgucuac cuccccggcg ucaucgccgc caucguccag      420

cuccacaacg gcaccaagua caagaaguuc ccccacuggc ucgacaagug gaugcucacc      480

cgcaagcagu ucggccuccu cuccuucuuc uucgccgucc uccacgccau cuacucccuc      540

uccuacccca ugcgccgcuc cuaccgcuac aagcuccuca acugggccua ccagcagguc      600

cagcagaaca aggaggacgc cuggaucgag cacgacgucu ggcgcaugga gaucuacguc      660

ucccucggca ucgucggccu cgccauccuc gcccuccucg ccgucaccuc cauccccucc      720

gucuccgacu cccucaccug gcgcgaguuc cacuacaucc aguccaagcu cggcaucguc      780

ucccuccucc ucggcaccau ccacgcccuc aucuucgccu ggaacaagug gaucgacauc      840

aagcaguucg ucugguacac cccccccacc uucaugaucg ccgucuuccu ccccaucguc      900

guccucaucu ucaaguccau ccucuuccuc cccugccucc gcaagaagau ccucaagauc      960

cgccacggcu gggaggacgu caccaagauc aacaagaccg agaucugcuc ccagcucuga     1020


<210>  3531
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       STEAP-1__Homo_sapiens__AAD15620

<400>  3531
auggagagca gaaaggacau caccaaccag gaggaacugu ggaaaaugaa gcccaggcgg       60

aaucucgaag aggaugacua ccuucacaaa gauacaggcg aaacuuccau gcugaagcgc      120

ccuguguugu uacaucugca ccaaacggcc caugcugacg aguucgauug cccaucugag      180

cuacagcaca cccaggaacu cuuuccgcag uggcaucugc ccauuaaaau agcagccauc      240

auugcgucac uuacauuccu guauacuuug cuccgagagg ucauccaccc ucuggcuacc      300

agucaccaac aguacuuuua uaagauucca auccugguua uaaacaaggu gcuccccaug      360

guaagcauca cauuacuggc ccuuguguac uugccugggg ucauugcagc caucgugcag      420

cugcauaaug gaaccaaaua uaagaaauuc ccacacuggc uagacaagug gaugcucacu      480

cguaaacagu uuggucugcu uuccuucuuu uucgcuguuc ugcaugcaau uuacucuuug      540

ucguauccca ugagaagguc auaccgguac aagcuccuga acugggccua ucaacaggug      600

cagcagaaua aggaagaugc uuggaucgag cacgacgucu ggcgcaugga gauauacgug      660

agcuuaggca uuguagggcu ggccauccuc gcgcuucugg caguuacaag uauuccuucc      720

gugucugaua gcuugaccug gagagaauuu cacuauaucc aauccaaacu aggaaucguc      780

ucacugcucc ugggcacgau ucaugcccuu auauucgcuu ggaacaagug gaucgacauu      840

aaacaguuug ugugguacac uccaccgacc uucaugaucg ccguguuucu gcccauaguc      900

guuuugauuu ucaagaguau ccucuuccug ccuuguuuaa ggaaaaagau ccugaaaauu      960

cggcacgguu gggaggaugu gacaaagauc aauaagacug aaauuugcag ccagcuauga     1020


<210>  3532
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       STEAP-1__Homo_sapiens__AAD15620

<400>  3532
auggagagca gaaaggacau caccaaccag gaggagcugu ggaagaugaa gcccagaaga       60

aaccuggagg aggacgacua ccugcacaag gacaccggcg agaccagcau gcugaagaga      120

cccgugcugc ugcaccugca ccagaccgcc cacgccgacg aguucgacug ccccagcgag      180

cugcagcaca cccaggagcu guucccccag uggcaccugc ccaucaagau cgccgccauc      240

aucgccagcc ugaccuuccu guacacccug cugagagagg ugauccaccc ccuggccacc      300

agccaccagc aguacuucua caagaucccc auccugguga ucaacaaggu gcugcccaug      360

gugagcauca cccugcuggc ccugguguac cugcccggcg ugaucgccgc caucgugcag      420

cugcacaacg gcaccaagua caagaaguuc ccccacuggc uggacaagug gaugcugacc      480

agaaagcagu ucggccugcu gagcuucuuc uucgccgugc ugcacgccau cuacagccug      540

agcuacccca ugagaagaag cuacagauac aagcugcuga acugggccua ccagcaggug      600

cagcagaaca aggaggacgc cuggaucgag cacgacgugu ggagaaugga gaucuacgug      660

agccugggca ucgugggccu ggccauccug gcccugcugg ccgugaccag cauccccagc      720

gugagcgaca gccugaccug gagagaguuc cacuacaucc agagcaagcu gggcaucgug      780

agccugcugc ugggcaccau ccacgcccug aucuucgccu ggaacaagug gaucgacauc      840

aagcaguucg ugugguacac cccccccacc uucaugaucg ccguguuccu gcccaucgug      900

gugcugaucu ucaagagcau ccuguuccug cccugccuga gaaagaagau ccugaagauc      960

agacacggcu gggaggacgu gaccaagauc aacaagaccg agaucugcag ccagcuguga     1020


<210>  3533
<211>  1020
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       STEAP-1__Homo_sapiens__AAD15620

<400>  3533
auggagagca gaaaggacau caccaaccag gaggaacugu ggaaaaugaa gccccggcgc       60

aaucucgaag aggaugacua ccugcacaaa gauacaggcg aaacguccau gcuuaagaga      120

ccugugcugc uccaucugca ccaaaccgcc caugcugacg aguucgauug cccgucugag      180

cuucagcaca cacaggaacu guuuccccag uggcaucucc cuauuaaaau cgccgcgauu      240

aucgcuagcc ugaccuuccu guauacacuc cugcgggagg ucauucaccc ccuugccacc      300

ucccaccaac aguacuuuua uaagaucccu auccugguua uuaacaaggu gcuccccaug      360

gugucuauca cacugcuugc ccuggucuac cucccugggg ugauugcugc caucguucag      420

cugcauaaug gaaccaaaua uaagaaauuc ccgcacuggc uggacaagug gaugcucacg      480

cgcaaacagu uuggccugcu uagcuucuuu uucgcugugc ugcaugccau uuacucccuc      540

ucuuauccca ugagacggag cuaccgcuac aagcugcuua acugggcgua ucaacagguc      600

cagcagaaua aggaagaugc cuggaucgag cacgacgugu ggagaaugga gauuuacguu      660

ucccugggga ucgugggacu cgcuauccug gcccugcucg cugucaccag cauuccuucu      720

guguccgaua gccugacaug gcgggaauuu cacuauaucc aaucuaaacu uggcauugug      780

ucccugcucc uggggaccau ccaugcccuu auuuucgcgu ggaacaagug gaucgacauc      840

aaacaguuug ucugguacac acccccuacc uucaugauug ccguuuuucu gcccaucgug      900

gugcucauuu ucaagagcau ccuguuccug ccgugucucc gcaaaaagau ucugaaaauc      960

agacacggau gggaggaugu cacgaagauc aauaagacag aaauuugcuc ucagcuuuga     1020


<210>  3534
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Survivin-2B__Homo_sapiens__O15392-2

<400>  3534

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala 
65                  70                  75                  80  


Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr 
                85                  90                  95      


Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser Val 
            100                 105                 110         


Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu Asp 
        115                 120                 125             


Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu Thr Asn Asn Lys Lys 
    130                 135                 140                 


Lys Glu Phe Glu Glu Thr Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 
145                 150                 155                 160 


Leu Ala Ala Met Asp 
                165 


<210>  3535
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3535
augggugccc cgacguugcc cccugccugg cagcccuuuc ucaaggacca ccgcaucucu       60

acauucaaga acuggcccuu cuuggagggc ugcgccugca ccccggagcg gauggccgag      120

gcuggcuuca uccacugccc cacugagaac gagccagacu uggcccagug uuucuucugc      180

uucaaggagc uggaaggcug ggagccagau gacgacccca uugggccggg cacgguggcu      240

uacgccugua auaccagcac uuugggaggc cgaggcgggc ggaucacgag agaggaacau      300

aaaaagcauu cguccgguug cgcuuuccuu ucugucaaga agcaguuuga agaauuaacc      360

cuuggugaau uuuugaaacu ggacagagaa agagccaaga acaaaauugc aaaggaaacc      420

aacaauaaga agaaagaauu ugaggaaacu gcggagaaag ugcgccgugc caucgagcag      480

cuggcugcca uggauuga                                                    498


<210>  3536
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3536
augggcgccc ccacccugcc gcccgccugg cagcccuucc ucaaggacca ccgcaucagc       60

accuucaaga acuggcccuu ccuggagggg ugcgcgugca cgccggagcg gauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc uggcccagug cuucuucugc      180

uucaaggagc ucgaggggug ggagcccgac gacgacccga ucggccccgg gaccguggcc      240

uacgcgugca acaccuccac gcugggcggc cgcgggggcc ggaucacccg cgaggagcac      300

aagaagcaca gcuccgggug cgccuuccug agcgucaaga agcaguucga ggagcucacc      360

cugggcgagu uccugaagcu cgaccgggag cgcgccaaga acaagaucgc caaggagacc      420

aacaacaaga agaaggaguu cgaggagacg gcggagaagg ugcggcgcgc caucgagcag      480

cuggccgcca uggacuga                                                    498


<210>  3537
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3537
augggcgccc ccacccuccc ccccgccugg cagcccuucc ucaaggacca ccgcaucucc       60

accuucaaga acuggcccuu ccucgagggc ugcgccugca cccccgagcg cauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc ucgcccagug cuucuucugc      180

uucaaggagc ucgagggcug ggagcccgac gacgacccca ucggccccgg caccgucgcc      240

uacgccugca acaccuccac ccucggcggc cgcggcggcc gcaucacccg cgaggagcac      300

aagaagcacu ccuccggcug cgccuuccuc uccgucaaga agcaguucga ggagcucacc      360

cucggcgagu uccucaagcu cgaccgcgag cgcgccaaga acaagaucgc caaggagacc      420

aacaacaaga agaaggaguu cgaggagacc gccgagaagg uccgccgcgc caucgagcag      480

cucgccgcca uggacuga                                                    498


<210>  3538
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3538
augggcgccc ccacccugcc uccagcuugg cagccguucc ucaaggacca cagaaucagc       60

acauuuaaaa acuggcccuu ccuugagggg ugcgcaugua cuccugaaag gauggccgag      120

gcgggauuua uucauugccc aacggaaaau gagcccgauc uggcucaaug uuucuuuugc      180

uucaaggaau uggaggguug ggagccugac gaugacccaa uaggccccgg gaccguggcc      240

uacgcaugua acacauccac uuuaggaggc cggggugggc gcaucacccg agaagaacac      300

aaaaagcauu cuucaggaug cgccuuucug agugucaaaa agcaguucga ggagcuaaca      360

cucggcgagu uucugaaacu ugaucgugaa agagcuaaga auaagauugc aaaagagacc      420

aacaauaaga aaaaggaguu cgaagaaacu gccgagaagg uuaggcgggc uaucgagcag      480

cuggccgcga uggacuga                                                    498


<210>  3539
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3539
augggcgccc ccacccugcc ccccgccugg cagcccuucc ugaaggacca cagaaucagc       60

accuucaaga acuggcccuu ccuggagggc ugcgccugca cccccgagag aauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc uggcccagug cuucuucugc      180

uucaaggagc uggagggcug ggagcccgac gacgacccca ucggccccgg caccguggcc      240

uacgccugca acaccagcac ccugggcggc agaggcggca gaaucaccag agaggagcac      300

aagaagcaca gcagcggcug cgccuuccug agcgugaaga agcaguucga ggagcugacc      360

cugggcgagu uccugaagcu ggacagagag agagccaaga acaagaucgc caaggagacc      420

aacaacaaga agaaggaguu cgaggagacc gccgagaagg ugagaagagc caucgagcag      480

cuggccgcca uggacuga                                                    498


<210>  3540
<211>  498
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Survivin-2B__Homo_sapiens__CCDS32752.1

<400>  3540
augggcgccc ccacccugcc uccggcuugg cagcccuucc ucaaggacca cagaaucagc       60

acauuuaaaa acuggccuuu ccuggagggg ugcgccugua cgcccgaacg gauggcggag      120

gcuggauuua uucauugccc uaccgaaaau gagcccgauc uugcccaaug uuucuuuugc      180

uucaaggaac uggagggcug ggagccugac gaugacccga ucgggcccgg aacaguggcc      240

uacgcuugua acaccuccac acucggcggg cgcggaggca gaauuacccg ggaagaacac      300

aaaaagcauu cuagcggcug cgccuuucug uccgucaaaa agcaguucga ggagcuuaca      360

cugggggagu uucucaagcu ggaucgcgaa agagcuaaaa auaagaucgc caaagagacc      420

aacaauaaga aaaaggaguu cgaagaaacg gcggagaagg uucggcgcgc cauugagcag      480

cuggcugcca uggacuga                                                    498


<210>  3541
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  survivin__Homo_sapiens__O15392

<400>  3541

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  3542
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  survivin__Homo_sapiens__AAC51660

<400>  3542
augggugccc cgacguugcc cccugccugg cagcccuuuc ucaaggacca ccgcaucucu       60

acauucaaga acuggcccuu cuuggagggc ugcgccugca ccccggagcg gauggccgag      120

gcuggcuuca uccacugccc cacugagaac gagccagacu uggcccagug uuucuucugc      180

uucaaggagc uggaaggcug ggagccagau gacgacccca uagaggaaca uaaaaagcau      240

ucguccgguu gcgcuuuccu uucugucaag aagcaguuug aagaauuaac ccuuggugaa      300

uuuuugaaac uggacagaga aagagccaag aacaaaauug caaaggaaac caacaauaag      360

aagaaagaau uugaggaaac ugcgaagaaa gugcgccgug ccaucgagca gcuggcugcc      420

auggauuga                                                              429


<210>  3543
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       survivin__Homo_sapiens__AAC51660

<400>  3543
augggcgccc ccacccugcc gcccgccugg cagcccuucc ucaaggacca ccgcaucagc       60

accuucaaga acuggcccuu ccuggagggg ugcgcgugca cgccggagcg gauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc uggcccagug cuucuucugc      180

uucaaggagc ucgaggggug ggagcccgac gacgacccga ucgaggagca caagaagcac      240

uccagcggcu gcgccuuccu guccgugaag aagcaguucg aggagcugac ccucggggag      300

uuccugaagc uggaccgcga gcgggcgaag aacaagaucg ccaaggagac caacaacaag      360

aagaaggagu ucgaggagac ggccaagaag guccgccggg ccaucgagca gcucgcggcc      420

auggacuga                                                              429


<210>  3544
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       survivin__Homo_sapiens__AAC51660

<400>  3544
augggcgccc ccacccuccc ccccgccugg cagcccuucc ucaaggacca ccgcaucucc       60

accuucaaga acuggcccuu ccucgagggc ugcgccugca cccccgagcg cauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc ucgcccagug cuucuucugc      180

uucaaggagc ucgagggcug ggagcccgac gacgacccca ucgaggagca caagaagcac      240

uccuccggcu gcgccuuccu cuccgucaag aagcaguucg aggagcucac ccucggcgag      300

uuccucaagc ucgaccgcga gcgcgccaag aacaagaucg ccaaggagac caacaacaag      360

aagaaggagu ucgaggagac cgccaagaag guccgccgcg ccaucgagca gcucgccgcc      420

auggacuga                                                              429


<210>  3545
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       survivin__Homo_sapiens__AAC51660

<400>  3545
augggcgccc ccacccugcc uccagcuugg cagccguucc ucaaggacca cagaaucagc       60

acauuuaaaa acuggcccuu ccuugagggg ugcgcaugua cuccugaaag gauggccgag      120

gcgggauuua uucauugccc aacggaaaau gagcccgauc uggcucaaug uuucuuuugc      180

uucaaggaau uggaggguug ggagccugac gaugacccaa uagaagaaca caaaaagcau      240

uccucuggcu gugccuuuuu aucagugaaa aagcaguucg aggagcugac ccuaggggag      300

uuucucaagc uggaucggga acgcgccaaa aacaagaucg caaaagagac aaauaacaag      360

aaaaaggagu ucgaagaaac ugcuaagaaa guccgacgug caauugagca gcuugccgcu      420

auggacuga                                                              429


<210>  3546
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       survivin__Homo_sapiens__AAC51660

<400>  3546
augggcgccc ccacccugcc ccccgccugg cagcccuucc ugaaggacca cagaaucagc       60

accuucaaga acuggcccuu ccuggagggc ugcgccugca cccccgagag aauggccgag      120

gccggcuuca uccacugccc caccgagaac gagcccgacc uggcccagug cuucuucugc      180

uucaaggagc uggagggcug ggagcccgac gacgacccca ucgaggagca caagaagcac      240

agcagcggcu gcgccuuccu gagcgugaag aagcaguucg aggagcugac ccugggcgag      300

uuccugaagc uggacagaga gagagccaag aacaagaucg ccaaggagac caacaacaag      360

aagaaggagu ucgaggagac cgccaagaag gugagaagag ccaucgagca gcuggccgcc      420

auggacuga                                                              429


<210>  3547
<211>  429
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       survivin__Homo_sapiens__AAC51660

<400>  3547
augggcgccc ccacccugcc uccggcuugg cagcccuucc ucaaggacca cagaaucagc       60

acauuuaaaa acuggccuuu ccuggagggg ugcgccugua cgcccgaacg gauggcggag      120

gcuggauuua uucauugccc uaccgaaaau gagcccgauc uugcccaaug uuucuuuugc      180

uucaaggaac uggagggcug ggagccugac gaugacccga ucgaagaaca caaaaagcau      240

uccucugggu gugccuuucu cagcgugaaa aagcaguucg aggagcugac acuuggagag      300

uuucugaagc ucgaucgcga aagagcuaaa aacaagauug ccaaagagac caauaacaag      360

aaaaaggagu ucgaagaaac agcuaagaaa guccggcgcg ccaucgagca gcuggcggcc      420

auggacuga                                                              429


<210>  3548
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__A0A024R0I2

<400>  3548

Met Glu Lys Gln Lys Pro Phe Ala Leu Phe Val Pro Pro Arg Ser Ser 
1               5                   10                  15      


Ser Ser Gln Val Ser Ala Val Lys Pro Gln Thr Leu Gly Gly Asp Ser 
            20                  25                  30          


Thr Phe Phe Lys Ser Phe Asn Lys Cys Thr Glu Asp Asp Phe Glu Phe 
        35                  40                  45              


Pro Phe Ala Lys Thr Asn Leu Ser Lys Asn Gly Glu Asn Ile Asp Ser 
    50                  55                  60                  


Asp Pro Ala Leu Gln Lys Val Asn Phe Leu Pro Val Leu Glu Gln Val 
65                  70                  75                  80  


Gly Asn Ser Asp Cys His Tyr Gln Glu Gly Leu Lys Asp Ser Asp Leu 
                85                  90                  95      


Glu Asn Ser Glu Gly Leu Ser Arg Val Tyr Ser Lys Leu Tyr Lys Glu 
            100                 105                 110         


Ala Glu Lys Ile Lys Lys Trp Lys Val Ser Thr Glu Ala Glu Leu Arg 
        115                 120                 125             


Gln Lys Glu Ser Lys Leu Gln Glu Asn Arg Lys Ile Ile Glu Ala Gln 
    130                 135                 140                 


Arg Lys Ala Ile Gln Glu Leu Gln Phe Gly Asn Glu Lys Val Ser Leu 
145                 150                 155                 160 


Lys Leu Glu Glu Gly Ile Gln Glu Asn Lys Asp Leu Ile Lys Glu Asn 
                165                 170                 175     


Asn Ala Thr Arg His Leu Cys Asn Leu Leu Lys Glu Thr Cys Ala Arg 
            180                 185                 190         


Ser Ala Glu Lys Thr Lys Lys Tyr Glu Tyr Glu Arg Glu Glu Thr Arg 
        195                 200                 205             


Gln Val Tyr Met Asp Leu Asn Asn Asn Ile Glu Lys Met Ile Thr Ala 
    210                 215                 220                 


Phe Glu Glu Leu Arg Val Gln Ala Glu Asn Ser Arg Leu Glu Met His 
225                 230                 235                 240 


Phe Lys Leu Lys Glu Asp Tyr Glu Lys Ile Gln His Leu Glu Gln Glu 
                245                 250                 255     


Tyr Lys Lys Glu Ile Asn Asp Lys Glu Lys Gln Val Ser Leu Leu Leu 
            260                 265                 270         


Ile Gln Ile Thr Glu Lys Glu Asn Lys Met Lys Asp Leu Thr Phe Leu 
        275                 280                 285             


Leu Glu Glu Ser Arg Asp Lys Val Asn Gln Leu Glu Glu Lys Thr Lys 
    290                 295                 300                 


Leu Gln Ser Glu Asn Leu Lys Gln Ser Ile Glu Lys Gln His His Leu 
305                 310                 315                 320 


Thr Lys Glu Leu Glu Asp Ile Lys Val Ser Leu Gln Arg Ser Val Ser 
                325                 330                 335     


Thr Gln Lys Ala Leu Glu Glu Asp Leu Gln Ile Ala Thr Lys Thr Ile 
            340                 345                 350         


Cys Gln Leu Thr Glu Glu Lys Glu Thr Gln Met Glu Glu Ser Asn Lys 
        355                 360                 365             


Ala Arg Ala Ala His Ser Phe Val Val Thr Glu Phe Glu Thr Thr Val 
    370                 375                 380                 


Cys Ser Leu Glu Glu Leu Leu Arg Thr Glu Gln Gln Arg Leu Glu Lys 
385                 390                 395                 400 


Asn Glu Asp Gln Leu Lys Ile Leu Thr Met Glu Leu Gln Lys Lys Ser 
                405                 410                 415     


Ser Glu Leu Glu Glu Met Thr Lys Leu Thr Asn Asn Lys Glu Val Glu 
            420                 425                 430         


Leu Glu Glu Leu Lys Lys Val Leu Gly Glu Lys Glu Thr Leu Leu Tyr 
        435                 440                 445             


Glu Asn Lys Gln Phe Glu Lys Ile Ala Glu Glu Leu Lys Gly Thr Glu 
    450                 455                 460                 


Gln Glu Leu Ile Gly Leu Leu Gln Ala Arg Glu Lys Glu Val His Asp 
465                 470                 475                 480 


Leu Glu Ile Gln Leu Thr Ala Ile Thr Thr Ser Glu Gln Tyr Tyr Ser 
                485                 490                 495     


Lys Glu Val Lys Asp Leu Lys Thr Glu Leu Glu Asn Glu Lys Leu Lys 
            500                 505                 510         


Asn Thr Glu Leu Thr Ser His Cys Asn Lys Leu Ser Leu Glu Asn Lys 
        515                 520                 525             


Glu Leu Thr Gln Glu Thr Ser Asp Met Thr Leu Glu Leu Lys Asn Gln 
    530                 535                 540                 


Gln Glu Asp Ile Asn Asn Asn Lys Lys Gln Glu Glu Arg Met Leu Lys 
545                 550                 555                 560 


Gln Ile Glu Asn Leu Gln Glu Thr Glu Thr Gln Leu Arg Asn Glu Leu 
                565                 570                 575     


Glu Tyr Val Arg Glu Glu Leu Lys Gln Lys Arg Asp Glu Val Lys Cys 
            580                 585                 590         


Lys Leu Asp Lys Ser Glu Glu Asn Cys Asn Asn Leu Arg Lys Gln Val 
        595                 600                 605             


Glu Asn Lys Asn Lys Tyr Ile Glu Glu Leu Gln Gln Glu Asn Lys Ala 
    610                 615                 620                 


Leu Lys Lys Lys Gly Thr Ala Glu Ser Lys Gln Leu Asn Val Tyr Glu 
625                 630                 635                 640 


Ile Lys Val Asn Lys Leu Glu Leu Glu Leu Glu Ser Ala Lys Gln Lys 
                645                 650                 655     


Phe Gly Glu Ile Thr Asp Thr Tyr Gln Lys Glu Ile Glu Asp Lys Lys 
            660                 665                 670         


Ile Ser Glu Glu Asn Leu Leu Glu Glu Val Glu Lys Ala Lys Val Ile 
        675                 680                 685             


Ala Asp Glu Ala Val Lys Leu Gln Lys Glu Ile Asp Lys Arg Cys Gln 
    690                 695                 700                 


His Lys Ile Ala Glu Met Val Ala Leu Met Glu Lys His Lys His Gln 
705                 710                 715                 720 


Tyr Asp Lys Ile Ile Glu Glu Arg Asp Ser Glu Leu Gly Leu Tyr Lys 
                725                 730                 735     


Ser Lys Glu Gln Glu Gln Ser Ser Leu Arg Ala Ser Leu Glu Ile Glu 
            740                 745                 750         


Leu Ser Asn Leu Lys Ala Glu Leu Leu Ser Val Lys Lys Gln Leu Glu 
        755                 760                 765             


Ile Glu Arg Glu Glu Lys Glu Lys Leu Lys Arg Glu Ala Lys Glu Asn 
    770                 775                 780                 


Thr Ala Thr Leu Lys Glu Lys Lys Asp Lys Lys Thr Gln Thr Phe Leu 
785                 790                 795                 800 


Leu Glu Thr Pro Glu Ile Tyr Trp Lys Leu Asp Ser Lys Ala Val Pro 
                805                 810                 815     


Ser Gln Thr Val Ser Arg Asn Phe Thr Ser Val Asp His Gly Ile Ser 
            820                 825                 830         


Lys Asp Lys Arg Asp Tyr Leu Trp Thr Ser Ala Lys Asn Thr Leu Ser 
        835                 840                 845             


Thr Pro Leu Pro Lys Ala Tyr Thr Val Lys Thr Pro Thr Lys Pro Lys 
    850                 855                 860                 


Leu Gln Gln Arg Glu Asn Leu Asn Ile Pro Ile Glu Glu Ser Lys Lys 
865                 870                 875                 880 


Lys Arg Lys Met Ala Phe Glu Phe Asp Ile Asn Ser Asp Ser Ser Glu 
                885                 890                 895     


Thr Thr Asp Leu Leu Ser Met Val Ser Glu Glu Glu Thr Leu Lys Thr 
            900                 905                 910         


Leu Tyr Arg Asn Asn Asn Pro Pro Ala Ser His Leu Cys Val Lys Thr 
        915                 920                 925             


Pro Lys Lys Ala Pro Ser Ser Leu Thr Thr Pro Gly Ser Thr Leu Lys 
    930                 935                 940                 


Phe Gly Ala Ile Arg Lys Met Arg Glu Asp Arg Trp Ala Val Ile Ala 
945                 950                 955                 960 


Lys Met Asp Arg Lys Lys Lys Leu Lys Glu Ala Glu Lys Leu Phe Val 
                965                 970                 975     






<210>  3549
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__EAW56623

<400>  3549
auggaaaagc aaaagcccuu ugcauuguuc guaccaccga gaucaagcag cagucaggug       60

ucugcgguga aaccucagac ccugggaggc gauuccacuu ucuucaagag uuucaacaaa      120

uguacugaag augauuuuga guuuccauuu gcaaagacua aucucuccaa aaauggggaa      180

aacauugauu cagauccugc uuuacaaaaa guuaauuucu ugcccgugcu ugagcagguu      240

gguaauucug acugucacua ucaggaagga cuaaaagacu cugauuugga gaauucagag      300

ggauugagca gaguguauuc aaaacuguau aaggaggcug aaaagauaaa aaaauggaaa      360

guaaguacag aagcugaacu gagacagaaa gaaaguaagu ugcaagaaaa cagaaagaua      420

auugaagcac agcgaaaagc cauucaggaa cugcaauuug gaaaugaaaa aguaaguuug      480

aaauuagaag aaggaauaca agaaaauaaa gauuuaauaa aagagaauaa ugccacaagg      540

cauuuaugua aucuacucaa agaaaccugu gcuagaucug cagaaaagac aaagaaauau      600

gaauaugaac gggaagaaac caggcaaguu uauauggauc uaaauaauaa cauugagaaa      660

augauaacag cuuuugagga acuucgugug caagcugaga auuccagacu ggaaaugcau      720

uuuaaguuaa aggaagauua ugaaaaaauc caacaccuug aacaagaaua caagaaggaa      780

auaaaugaca aggaaaagca gguaucacua cuauugaucc aaaucacuga gaaagaaaau      840

aaaaugaaag auuuaacauu ucugcuagag gaauccagag auaaaguuaa ucaauuagag      900

gaaaagacaa aauuacagag ugaaaacuua aaacaaucaa uugagaaaca gcaucauuug      960

acuaaagaac uagaagauau uaaaguguca uuacaaagaa gugugaguac ucaaaaggcu     1020

uuagaggaag auuuacagau agcaacaaaa acaauuuguc agcuaacuga agaaaaagaa     1080

acucaaaugg aagaaucuaa uaaagcuaga gcugcucauu cguuuguggu uacugaauuu     1140

gaaacuacug ucugcagcuu ggaagaauua uugagaacag aacagcaaag auuggaaaaa     1200

aaugaagauc aauugaaaau acuuaccaug gagcuucaaa agaaaucaag ugagcuggaa     1260

gagaugacua agcuuacaaa uaacaaagaa guagaacuug aagaauugaa aaaagucuug     1320

ggagaaaagg aaacacuuuu auaugaaaau aaacaauuug agaagauugc ugaagaauua     1380

aaaggaacag aacaagaacu aauuggucuu cuccaagcca gagagaaaga aguacaugau     1440

uuggaaauac aguuaacugc cauuaccaca agugaacagu auuauucaaa agagguuaaa     1500

gaucuaaaaa cugagcuuga aaacgagaag cuuaagaaua cugaauuaac uucacacugc     1560

aacaagcuuu cacuagaaaa caaagagcuc acacaggaaa caagugauau gacccuagaa     1620

cucaagaauc agcaagaaga uauuaauaau aacaaaaagc aagaagaaag gauguugaaa     1680

caaauagaaa aucuucaaga aacagaaacc caauuaagaa augaacuaga auaugugaga     1740

gaagagcuaa aacagaaaag agaugaaguu aaauguaaau uggacaagag ugaagaaaau     1800

uguaacaauu uaaggaaaca aguugaaaau aaaaacaagu auauugaaga acuucagcag     1860

gagaauaagg ccuugaaaaa aaaagguaca gcagaaagca agcaacugaa uguuuaugag     1920

auaaagguca auaaauuaga guuagaacua gaaagugcca aacagaaauu uggagaaauc     1980

acagacaccu aucagaaaga aauugaggac aaaaagauau cagaagaaaa ucuuuuggaa     2040

gagguugaga aagcaaaagu aauagcugau gaagcaguaa aauuacagaa agaaauugau     2100

aagcgauguc aacauaaaau agcugaaaug guagcacuua uggaaaaaca uaagcaccaa     2160

uaugauaaga ucauugaaga aagagacuca gaauuaggac uuuauaagag caaagaacaa     2220

gaacagucau cacugagagc aucuuuggag auugaacuau ccaaucucaa agcugaacuu     2280

uugucuguua agaagcaacu ugaaauagaa agagaagaga aggaaaaacu caaaagagag     2340

gcaaaagaaa acacagcuac ucuuaaagaa aaaaaagaca agaaaacaca aacauuuuua     2400

uuggaaacac cugaaauuua uuggaaauug gauucuaaag caguuccuuc acaaacugua     2460

ucucgaaauu ucacaucagu ugaucauggc auauccaaag auaaaagaga cuaucugugg     2520

acaucugcca aaaauacuuu aucuacacca uugccaaagg cauauacagu gaagacacca     2580

acaaaaccaa aacuacagca aagagaaaac uugaauauac ccauugaaga aaguaaaaaa     2640

aagagaaaaa uggccuuuga auuugauauu aauucagaua guucagaaac uacugaucuu     2700

uugagcaugg uuucagaaga agagacauug aaaacacugu auaggaacaa uaauccacca     2760

gcuucucauc uuugugucaa aacaccaaaa aaggccccuu caucucuaac aaccccugga     2820

ucuacacuga aguuuggagc uauaagaaaa augcgggagg accguugggc uguaauugcu     2880

aaaauggaua gaaaaaaaaa acuaaaagaa gcugaaaagu uauuuguuua a              2931


<210>  3550
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYCP1__Homo_sapiens__EAW56623

<400>  3550
auggagaagc agaagcccuu cgcccuguuc gugccgcccc gcagcuccag cucccagguc       60

agcgccguga agccccagac ccucggcggg gacuccaccu ucuucaagag cuucaacaag      120

ugcacggagg acgacuucga guuccccuuc gcgaagacca accuguccaa gaacggcgag      180

aacaucgaca gcgacccggc ccugcagaag gugaacuucc uccccguccu ggagcagguc      240

gggaacuccg acugccacua ccaggagggc cugaaggaca gcgaccucga gaacuccgag      300

gggcugagcc ggguguacuc caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu ccgccagaag gaguccaagc ugcaggagaa ccggaagauc      420

aucgaggccc agcgcaaggc gauccaggag cugcaguucg gcaacgagaa ggugagccuc      480

aagcuggagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccacccgg      540

caccucugca accugcugaa ggagacgugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gggaggagac ccgccaggug uacauggacc ucaacaacaa caucgagaag      660

augaucaccg cguucgagga gcugcggguc caggccgaga acagccgccu ggagaugcac      720

uucaagcuca aggaggacua cgagaagauc cagcaccugg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucucccug cuccugaucc agaucacgga gaaggagaac      840

aagaugaagg accugaccuu ccuccuggag gagagccggg acaaggugaa ccagcuggag      900

gagaagacca agcuccagag cgagaaccug aagcagucca ucgagaagca gcaccaccug      960

accaaggagc ucgaggacau caaggugagc cugcagcgcu ccgugagcac gcagaaggcc     1020

cuggaggagg accuccagau cgccaccaag accaucugcc agcugaccga ggagaaggag     1080

acgcagaugg aggaguccaa caaggcccgg gcggcccaca gcuucguggu caccgaguuc     1140

gagaccaccg ugugcucccu ggaggagcuc cugcgcacgg agcagcagcg gcuggagaag     1200

aacgaggacc agcucaagau ccugaccaug gagcugcaga agaaguccag cgagcucgag     1260

gagaugacca agcugaccaa caacaaggag guggagcugg aggagcucaa gaagguccug     1320

ggggagaagg agacgcugcu guacgagaac aagcaguucg agaagaucgc cgaggagcuc     1380

aagggcaccg agcaggagcu gaucgggcug cuccaggccc gcgagaagga ggugcacgac     1440

cuggagaucc agcugaccgc caucaccacg agcgagcagu acuacuccaa ggaggugaag     1500

gaccucaaga ccgagcugga gaacgagaag cugaagaaca ccgagcucac cagccacugc     1560

aacaagcugu cccuggagaa caaggagcuc acgcaggaga ccagcgacau gacccuggag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg gaugcucaag     1680

cagaucgaga accugcagga gaccgagacg cagcugcgca acgagcucga guacguccgg     1740

gaggagcuga agcagaagcg cgacgaggug aagugcaagc uggacaaguc cgaggagaac     1800

ugcaacaacc uccggaagca ggucgagaac aagaacaagu acaucgagga gcugcagcag     1860

gagaacaagg cgcugaagaa gaagggcacc gccgagagca agcagcucaa cguguacgag     1920

aucaagguga acaagcugga gcuggagcuc gaguccgcca agcagaaguu cggggagauc     1980

accgacaccu accagaagga gaucgaggac aagaagauca gcgaggagaa ccugcuggag     2040

gaggucgaga aggccaaggu gaucgccgac gaggcgguga agcuccagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuga uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacucc gagcugggcc ucuacaagag caaggagcag     2220

gagcagagcu cccugcgggc cagccuggag aucgagcucu ccaaccugaa ggccgagcug     2280

cucagcguga agaagcagcu ggagaucgag cgcgaggaga aggagaagcu gaagcgggag     2340

gcgaaggaga acaccgccac gcucaaggag aagaaggaca agaagaccca gaccuuccug     2400

cuggagaccc ccgagaucua cuggaagcuc gacuccaagg ccgugcccag ccagacgguc     2460

ucccgcaacu ucaccagcgu ggaccacggc aucuccaagg acaagcggga cuaccugugg     2520

accagcgcca agaacacccu guccacgccg cuccccaagg cguacaccgu gaagaccccc     2580

accaagccca agcugcagca gcgcgagaac cugaacaucc cgaucgagga gagcaagaag     2640

aagcggaaga uggccuucga guucgacauc aacuccgaca gcuccgagac gaccgaccuc     2700

cugagcaugg ucuccgagga ggagacccug aagacccucu accgcaacaa caacccgccc     2760

gccagccacc ugugcgugaa gacgcccaag aaggccccca gcucccugac cacccccggg     2820

agcacccuca aguucggcgc cauccggaag augcgcgagg accggugggc ggugaucgcc     2880

aagauggacc gcaagaagaa gcugaaggag gccgagaagc uguucgucug a              2931


<210>  3551
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYCP1__Homo_sapiens__EAW56623

<400>  3551
auggagaagc agaagcccuu cgcccucuuc gucccccccc gcuccuccuc cucccagguc       60

uccgccguca agccccagac ccucggcggc gacuccaccu ucuucaaguc cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accucuccaa gaacggcgag      180

aacaucgacu ccgaccccgc ccuccagaag gucaacuucc uccccguccu cgagcagguc      240

ggcaacuccg acugccacua ccaggagggc cucaaggacu ccgaccucga gaacuccgag      300

ggccucuccc gcgucuacuc caagcucuac aaggaggccg agaagaucaa gaaguggaag      360

gucuccaccg aggccgagcu ccgccagaag gaguccaagc uccaggagaa ccgcaagauc      420

aucgaggccc agcgcaaggc cauccaggag cuccaguucg gcaacgagaa ggucucccuc      480

aagcucgagg agggcaucca ggagaacaag gaccucauca aggagaacaa cgccacccgc      540

caccucugca accuccucaa ggagaccugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gcgaggagac ccgccagguc uacauggacc ucaacaacaa caucgagaag      660

augaucaccg ccuucgagga gcuccgcguc caggccgaga acucccgccu cgagaugcac      720

uucaagcuca aggaggacua cgagaagauc cagcaccucg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucucccuc cuccucaucc agaucaccga gaaggagaac      840

aagaugaagg accucaccuu ccuccucgag gagucccgcg acaaggucaa ccagcucgag      900

gagaagacca agcuccaguc cgagaaccuc aagcagucca ucgagaagca gcaccaccuc      960

accaaggagc ucgaggacau caaggucucc cuccagcgcu ccgucuccac ccagaaggcc     1020

cucgaggagg accuccagau cgccaccaag accaucugcc agcucaccga ggagaaggag     1080

acccagaugg aggaguccaa caaggcccgc gccgcccacu ccuucgucgu caccgaguuc     1140

gagaccaccg ucugcucccu cgaggagcuc cuccgcaccg agcagcagcg ccucgagaag     1200

aacgaggacc agcucaagau ccucaccaug gagcuccaga agaaguccuc cgagcucgag     1260

gagaugacca agcucaccaa caacaaggag gucgagcucg aggagcucaa gaagguccuc     1320

ggcgagaagg agacccuccu cuacgagaac aagcaguucg agaagaucgc cgaggagcuc     1380

aagggcaccg agcaggagcu caucggccuc cuccaggccc gcgagaagga gguccacgac     1440

cucgagaucc agcucaccgc caucaccacc uccgagcagu acuacuccaa ggaggucaag     1500

gaccucaaga ccgagcucga gaacgagaag cucaagaaca ccgagcucac cucccacugc     1560

aacaagcucu cccucgagaa caaggagcuc acccaggaga ccuccgacau gacccucgag     1620

cucaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg caugcucaag     1680

cagaucgaga accuccagga gaccgagacc cagcuccgca acgagcucga guacguccgc     1740

gaggagcuca agcagaagcg cgacgagguc aagugcaagc ucgacaaguc cgaggagaac     1800

ugcaacaacc uccgcaagca ggucgagaac aagaacaagu acaucgagga gcuccagcag     1860

gagaacaagg cccucaagaa gaagggcacc gccgagucca agcagcucaa cgucuacgag     1920

aucaagguca acaagcucga gcucgagcuc gaguccgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagaucu ccgaggagaa ccuccucgag     2040

gaggucgaga aggccaaggu caucgccgac gaggccguca agcuccagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuca uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacucc gagcucggcc ucuacaaguc caaggagcag     2220

gagcaguccu cccuccgcgc cucccucgag aucgagcucu ccaaccucaa ggccgagcuc     2280

cucuccguca agaagcagcu cgagaucgag cgcgaggaga aggagaagcu caagcgcgag     2340

gccaaggaga acaccgccac ccucaaggag aagaaggaca agaagaccca gaccuuccuc     2400

cucgagaccc ccgagaucua cuggaagcuc gacuccaagg ccguccccuc ccagaccguc     2460

ucccgcaacu ucaccuccgu cgaccacggc aucuccaagg acaagcgcga cuaccucugg     2520

accuccgcca agaacacccu cuccaccccc cuccccaagg ccuacaccgu caagaccccc     2580

accaagccca agcuccagca gcgcgagaac cucaacaucc ccaucgagga guccaagaag     2640

aagcgcaaga uggccuucga guucgacauc aacuccgacu ccuccgagac caccgaccuc     2700

cucuccaugg ucuccgagga ggagacccuc aagacccucu accgcaacaa caaccccccc     2760

gccucccacc ucugcgucaa gacccccaag aaggcccccu ccucccucac cacccccggc     2820

uccacccuca aguucggcgc cauccgcaag augcgcgagg accgcugggc cgucaucgcc     2880

aagauggacc gcaagaagaa gcucaaggag gccgagaagc ucuucgucug a              2931


<210>  3552
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYCP1__Homo_sapiens__EAW56623

<400>  3552
auggagaagc agaaacccuu cgcccuguuu gugccuccaa gaagcuccuc uucacaaguc       60

agugcuguua agccgcagac ccucggcggg gacagcacau ucuuuaaauc cuucaacaag      120

ugcacugaag augacuuuga guuccccuuu gcaaaaacga aucuuucuaa gaacggagaa      180

aauaucgauu cggacccugc ccugcagaag gugaacuucu ugccaguauu agaacaggug      240

gguaauucag auugucacua ccaagaaggc cugaaagaca gcgaucuaga gaacagugag      300

gggcucucca gggucuauuc uaagcuguac aaagaagcgg agaagauuaa aaaguggaag      360

gugagcaccg aagcugagcu ucggcagaaa gaguccaagc ugcaggaaaa ucgcaaaaua      420

aucgaggccc agcgaaaggc aauucaagaa uugcaguuug gaaacgagaa aguuucacuc      480

aagcuggaag agggcaucca ggagaauaaa gaccugauua aggaaaacaa ugccacacgu      540

caucucugca acuuacugaa ggagacuugu gcuagaagug cagagaaaac caagaaauau      600

gaguacgaaa gggaggagac acgccaggug uauauggauc uuaauaacaa uaucgaaaag      660

augauaaccg ccuucgagga auugcggguc caagcugaga acagcagacu ggaaaugcac      720

uuuaaacuaa aggaggacua cgagaagauc cagcaucucg aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca agugucucug cuucugaucc agauuacuga gaaagaaaau      840

aagaugaagg acuugacauu ccuccuggag gaauccaggg auaaaguaaa ccaguuagag      900

gaaaagacca aacugcaguc agagaaucuc aagcaaagca ucgagaaaca gcaccaucuu      960

acgaaggaac uggaggacau aaagguuagu uugcagcggu cuguguccac ucagaaagcc     1020

cuagaagagg accugcaaau ugcgaccaag acaaucugcc agcucacuga agagaaagag     1080

acccagaugg aagagagcaa caaggcacgc gccgcucacu cguuugucgu gacagaguuc     1140

gaaaccacgg uguguucucu ggaggaacuu cugcgaacug agcagcaaag auuggagaaa     1200

aaugaagauc agcucaagau ucugacaaug gaauuacaga aaaaguccuc agagcuggag     1260

gaaaugacca agcuaacuaa caauaaagag gucgaacucg aggaacugaa gaaaguucuu     1320

ggugagaagg agacauugcu guacgaaaac aaacaguucg agaagaucgc cgaggaacuc     1380

aaggggaccg aacaagagcu gaucggacuu cugcaggcaa gggagaaaga agugcacgac     1440

uuggagauuc agcucacggc uauaaccaca agugaacaau acuauagcaa ggagguaaaa     1500

gaucugaaga cugaauuaga gaaugagaaa cugaagaaca ccgaacuaac aucccauugc     1560

aauaagcucu cucuggagaa caaagaacuu acucaggaga ccagcgacau gacauuggag     1620

cugaagaauc agcaggaaga uaucaacaau aacaaaaagc aagaggaacg gaugcucaaa     1680

cagauugaga accugcagga aaccgagacu caguuacgua augagcugga auacgugcgc     1740

gaggaacuua agcaaaagag agacgagguc aaauguaagu uggauaaauc agaagagaac     1800

ugcaauaacc ucaggaaaca gguggagaau aaaaacaagu auaucgagga acugcagcag     1860

gaaaauaaag cccuaaagaa gaaaggcacg gcggagagua agcaacugaa cguuuacgaa     1920

auaaaaguga auaagcucga gcuggagcuu gaauccgcca aacagaaguu uggcgagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagauca gcgaggaaaa cuugcuggag     2040

gaagucgaga aagcaaaggu gauugcugac gaagccguaa aauuacaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug guugcccuca uggaaaagca uaaacaccag     2160

uacgacaaga uaaucgagga acgagacucu gagcuggggc uuuauaaauc aaaggaacag     2220

gagcaaagua gccugcgcgc auccuuggag auugaacucu cuaaucugaa ggccgagcua     2280

cugucgguga aaaagcagcu cgaaaucgag agagaagaga aagagaagcu gaaaagggaa     2340

gcuaaggaga acacugcgac ccuuaaggag aaaaaggaua aaaagacaca gaccuucuug     2400

cuggaaacuc ccgagaucua cuggaaauua gacagcaagg cagucccuuc ccagacagug     2460

ucacggaauu uuacgagugu cgaucacgga auuucuaaag acaagcgcga uuaccucugg     2520

accagcgcca agaacacucu guccacacca cuucccaagg cuuauaccgu gaagacaccu     2580

acuaaaccaa agcugcaaca gagagaaaau cuaaacauac cgaucgagga aagcaaaaag     2640

aagaggaaaa uggccuucga guuugacauu aacucagauu cuuccgaaac cacggaccuc     2700

cugaguaugg uuagcgagga ggaaaccuug aagacacugu accguaauaa caaucccccu     2760

gcaucucauu uaugcgugaa aacuccaaag aaagcccccu ccucacucac cacaccuggu     2820

aguacucuga aguucggcgc uauccggaag augcgagagg auagaugggc cguaauugca     2880

aaaauggaca ggaagaagaa acuuaaagaa gcggagaagc uguuugucug a              2931


<210>  3553
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYCP1__Homo_sapiens__EAW56623

<400>  3553
auggagaagc agaagcccuu cgcccuguuc gugcccccca gaagcagcag cagccaggug       60

agcgccguga agccccagac ccugggcggc gacagcaccu ucuucaagag cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accugagcaa gaacggcgag      180

aacaucgaca gcgaccccgc ccugcagaag gugaacuucc ugcccgugcu ggagcaggug      240

ggcaacagcg acugccacua ccaggagggc cugaaggaca gcgaccugga gaacagcgag      300

ggccugagca gaguguacag caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu gagacagaag gagagcaagc ugcaggagaa cagaaagauc      420

aucgaggccc agagaaaggc cauccaggag cugcaguucg gcaacgagaa ggugagccug      480

aagcuggagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccaccaga      540

caccugugca accugcugaa ggagaccugc gccagaagcg ccgagaagac caagaaguac      600

gaguacgaga gagaggagac cagacaggug uacauggacc ugaacaacaa caucgagaag      660

augaucaccg ccuucgagga gcugagagug caggccgaga acagcagacu ggagaugcac      720

uucaagcuga aggaggacua cgagaagauc cagcaccugg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggugagccug cugcugaucc agaucaccga gaaggagaac      840

aagaugaagg accugaccuu ccugcuggag gagagcagag acaaggugaa ccagcuggag      900

gagaagacca agcugcagag cgagaaccug aagcagagca ucgagaagca gcaccaccug      960

accaaggagc uggaggacau caaggugagc cugcagagaa gcgugagcac ccagaaggcc     1020

cuggaggagg accugcagau cgccaccaag accaucugcc agcugaccga ggagaaggag     1080

acccagaugg aggagagcaa caaggccaga gccgcccaca gcuucguggu gaccgaguuc     1140

gagaccaccg ugugcagccu ggaggagcug cugagaaccg agcagcagag acuggagaag     1200

aacgaggacc agcugaagau ccugaccaug gagcugcaga agaagagcag cgagcuggag     1260

gagaugacca agcugaccaa caacaaggag guggagcugg aggagcugaa gaaggugcug     1320

ggcgagaagg agacccugcu guacgagaac aagcaguucg agaagaucgc cgaggagcug     1380

aagggcaccg agcaggagcu gaucggccug cugcaggcca gagagaagga ggugcacgac     1440

cuggagaucc agcugaccgc caucaccacc agcgagcagu acuacagcaa ggaggugaag     1500

gaccugaaga ccgagcugga gaacgagaag cugaagaaca ccgagcugac cagccacugc     1560

aacaagcuga gccuggagaa caaggagcug acccaggaga ccagcgacau gacccuggag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagag aaugcugaag     1680

cagaucgaga accugcagga gaccgagacc cagcugagaa acgagcugga guacgugaga     1740

gaggagcuga agcagaagag agacgaggug aagugcaagc uggacaagag cgaggagaac     1800

ugcaacaacc ugagaaagca gguggagaac aagaacaagu acaucgagga gcugcagcag     1860

gagaacaagg cccugaagaa gaagggcacc gccgagagca agcagcugaa cguguacgag     1920

aucaagguga acaagcugga gcuggagcug gagagcgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagauca gcgaggagaa ccugcuggag     2040

gagguggaga aggccaaggu gaucgccgac gaggccguga agcugcagaa ggagaucgac     2100

aagagaugcc agcacaagau cgccgagaug guggcccuga uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gagagacagc gagcugggcc uguacaagag caaggagcag     2220

gagcagagca gccugagagc cagccuggag aucgagcuga gcaaccugaa ggccgagcug     2280

cugagcguga agaagcagcu ggagaucgag agagaggaga aggagaagcu gaagagagag     2340

gccaaggaga acaccgccac ccugaaggag aagaaggaca agaagaccca gaccuuccug     2400

cuggagaccc ccgagaucua cuggaagcug gacagcaagg ccgugcccag ccagaccgug     2460

agcagaaacu ucaccagcgu ggaccacggc aucagcaagg acaagagaga cuaccugugg     2520

accagcgcca agaacacccu gagcaccccc cugcccaagg ccuacaccgu gaagaccccc     2580

accaagccca agcugcagca gagagagaac cugaacaucc ccaucgagga gagcaagaag     2640

aagagaaaga uggccuucga guucgacauc aacagcgaca gcagcgagac caccgaccug     2700

cugagcaugg ugagcgagga ggagacccug aagacccugu acagaaacaa caaccccccc     2760

gccagccacc ugugcgugaa gacccccaag aaggccccca gcagccugac cacccccggc     2820

agcacccuga aguucggcgc caucagaaag augagagagg acagaugggc cgugaucgcc     2880

aagauggaca gaaagaagaa gcugaaggag gccgagaagc uguucgugug a              2931


<210>  3554
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYCP1__Homo_sapiens__EAW56623

<400>  3554
auggagaagc agaaacccuu cgcccuguuu gugccuccga gaagcuccuc uagccaaguc       60

uccgcuguua agccccagac ccucggcggg gacucuacau ucuuuaagag cuucaacaag      120

ugcacggaag augacuuuga guucccuuuu gccaaaacca aucuguccaa gaacggagaa      180

aauaucgauu cugaccccgc gcuucagaag gugaacuucc ugccugugcu cgagcagguc      240

ggcaauagcg auugucacua ccaagaaggg cugaaagacu ccgaucuuga gaacagcgag      300

ggacugucuc ggguguauuc caagcucuac aaagaagcug agaagauuaa aaaguggaag      360

guuagcacag aagccgagcu gcgccagaaa gagucuaagc ugcaggaaaa uagaaaaauc      420

auugaggccc agcggaaggc uauccaagaa cuccaguuug gcaacgagaa agugucccug      480

aaacuugaag aggggauuca ggagaauaaa gaccugauca aggaaaacaa ugccacccgc      540

caucucugca accugcuuaa ggagacaugu gcuagaagcg ccgaaaagac caagaaauau      600

gaguacgaac gggaggagac acgccagguc uauauggauc ugaauaacaa uaucgaaaag      660

augauuaccg cguucgagga acucagagug caagccgaga acucucggcu ggaaaugcac      720

uuuaaacuga aggaggacua cgagaagauc cagcaucucg aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca aguuucccug cuucugaucc agauuacgga gaaagaaaau      840

aagaugaagg accucaccuu ccugcuugag gaaagccgcg auaaagugaa ccagcuggag      900

gaaaagacaa aacuccaguc cgagaaucug aagcaaucua ucgagaaaca gcaccaucug      960

accaaggaac ucgaggacau uaaggucagc cugcagagau ccgugagcac acagaaagcu     1020

cuugaagagg accugcaaau cgccaccaag acgaucugcc agcucacaga agagaaagag     1080

acccagaugg aagagucuaa caaggcucgg gccgcgcacu ccuuuguggu cacagaguuc     1140

gaaaccaccg uuuguagccu ggaggaacuu cugcgcacag agcagcaaag acucgaaaag     1200

aaugaggauc agcugaagau ucugacgaug gaacuccaga aaaagucuag cgagcuggag     1260

gaaaugacca aacuuacaaa caauaaagag guggaacugg aggaacucaa gaaagugcug     1320

ggagagaagg agacccugcu uuacgaaaac aaacaguucg agaagaucgc cgaggaacuc     1380

aagggcacag aacaagagcu gauuggccug cuccaggcuc gggagaaaga aguccacgac     1440

cuggagaucc agcuuaccgc cauuacgaca uccgaacaau acuauucuaa ggaggugaaa     1500

gaucugaaga ccgaacucga gaaugagaaa cugaagaaca ccgaacugac aagccauugc     1560

aauaaacuuu cccucgagaa caaagaacug acccaggaga caagcgacau gacgcuggag     1620

cucaagaauc agcaggaaga uaucaacaau aacaaaaagc aagaggaacg caugcugaaa     1680

cagaucgaga accuucagga aaccgagaca cagcugagaa augagcucga auacguucgg     1740

gaggaacuga agcaaaagag agacgaggug aaauguaagc uggauaaauc ugaagagaac     1800

ugcaauaacc uucgcaagca ggucgagaau aaaaacaagu auauugagga acuccagcag     1860

gaaaauaaag cucugaagaa gaaagggacc gccgagucca agcaacugaa cguguacgaa     1920

aucaaaguua auaagcucga gcuggagcuu gaaagcgcca aacagaaguu uggagagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagauuu cugaggaaaa ccugcucgag     2040

gaaguggaga aagcuaaggu caucgcggac gaagccguga aacugcaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug gucgcccuga uggaaaagca uaaacaccag     2160

uacgacaaga ucauugagga aagagacucc gagcuuggcc ucuauaaaag caaggaacag     2220

gagcaauccu cucugcgcgc cagccuggag aucgaacucu ccaaucugaa ggcugagcuu     2280

cugucuguga aaaagcagcu cgaaauugag cgggaagaga aagagaagcu gaaaagagaa     2340

gccaaggaga acacggcgac ccugaaggaa aagaaggaua aaaagacaca gaccuuccuu     2400

cuggagacac ccgagaucua cuggaaacuc gacagcaagg cuguuccuuc ccagaccgug     2460

agccgcaauu uuacgucugu cgaucacggg auuuccaaag acaagcggga uuaccugugg     2520

acaagcgcca agaacacccu cucuacaccg cugcccaaag ccuauaccgu gaagaccccu     2580

acaaaaccca aacuucaaca gagagaaaau cugaacaucc cuaucgagga auccaaaaag     2640

aagcgcaaaa uggcuuucga guuugacauu aacagcgauu cuagcgaaac gaccgaccuc     2700

cuguccaugg uuagcgagga ggaaacacug aagacccuuu accggaauaa caaucccccg     2760

gccucucauc ugugcgugaa aacaccuaag aaagcucccu ccagccucac cacgccugga     2820

uccacacuga aguucggcgc caucagaaag augcgcgagg aucggugggc ggucauugcc     2880

aaaauggaca gaaagaaaaa gcucaaagaa gcugagaagc uguuugugug a              2931


<210>  3555
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__B7ZLS9

<400>  3555

Met Glu Lys Gln Lys Pro Phe Ala Leu Phe Val Pro Pro Arg Ser Ser 
1               5                   10                  15      


Ser Ser Gln Val Ser Ala Val Lys Pro Gln Thr Leu Gly Gly Asp Ser 
            20                  25                  30          


Thr Phe Phe Lys Ser Phe Asn Lys Cys Thr Glu Asp Asp Phe Glu Phe 
        35                  40                  45              


Pro Phe Ala Lys Thr Asn Leu Ser Lys Asn Gly Glu Asn Ile Asp Ser 
    50                  55                  60                  


Asp Pro Ala Leu Gln Lys Val Asn Phe Leu Pro Val Phe Glu Gln Val 
65                  70                  75                  80  


Gly Asn Ser Asp Cys His Tyr Gln Glu Gly Leu Lys Asp Ser Asp Leu 
                85                  90                  95      


Glu Asn Ser Glu Gly Leu Ser Arg Val Tyr Ser Lys Leu Tyr Lys Glu 
            100                 105                 110         


Ala Glu Lys Ile Lys Lys Trp Lys Val Ser Thr Glu Ala Glu Leu Arg 
        115                 120                 125             


Gln Lys Glu Ser Lys Leu Gln Glu Asn Arg Lys Ile Ile Glu Ala Gln 
    130                 135                 140                 


Arg Lys Ala Ile Gln Glu Leu Gln Phe Gly Asn Glu Lys Val Ser Leu 
145                 150                 155                 160 


Lys Leu Glu Glu Gly Ile Gln Glu Asn Lys Asp Leu Ile Lys Glu Asn 
                165                 170                 175     


Asn Ala Thr Arg His Leu Cys Asn Leu Leu Lys Glu Thr Cys Ala Arg 
            180                 185                 190         


Ser Ala Glu Lys Thr Lys Lys Tyr Glu Tyr Glu Arg Glu Glu Thr Arg 
        195                 200                 205             


Gln Val Tyr Met Asp Leu Asn Ser Asn Ile Glu Lys Met Ile Thr Ala 
    210                 215                 220                 


Phe Glu Glu Leu Arg Val Gln Ala Glu Asn Ser Arg Leu Glu Met His 
225                 230                 235                 240 


Phe Lys Leu Lys Glu Asp Tyr Glu Lys Ile Gln His Leu Glu Gln Glu 
                245                 250                 255     


Tyr Lys Lys Glu Ile Asn Asp Lys Glu Lys Gln Val Ser Leu Leu Leu 
            260                 265                 270         


Ile Gln Ile Thr Glu Lys Glu Asn Lys Met Lys Asp Leu Thr Phe Leu 
        275                 280                 285             


Leu Glu Glu Ser Arg Asp Lys Val Asn Gln Leu Glu Glu Lys Thr Lys 
    290                 295                 300                 


Leu Gln Ser Glu Asn Leu Lys Gln Ser Ile Glu Lys Gln His His Leu 
305                 310                 315                 320 


Thr Lys Glu Leu Glu Asp Ile Lys Val Ser Leu Gln Arg Ser Val Ser 
                325                 330                 335     


Thr Gln Lys Ala Leu Glu Glu Asp Leu Gln Ile Ala Thr Lys Thr Ile 
            340                 345                 350         


Cys Gln Leu Thr Glu Glu Lys Glu Thr Gln Met Glu Glu Ser Asn Lys 
        355                 360                 365             


Ala Arg Ala Ala His Ser Phe Val Val Thr Glu Phe Glu Thr Thr Val 
    370                 375                 380                 


Cys Ser Leu Glu Glu Leu Leu Arg Thr Glu Gln Gln Arg Leu Glu Lys 
385                 390                 395                 400 


Asn Glu Asp Gln Leu Lys Ile Leu Thr Met Glu Leu Gln Lys Lys Ser 
                405                 410                 415     


Ser Glu Leu Glu Glu Met Thr Lys Leu Thr Asn Asn Lys Glu Val Glu 
            420                 425                 430         


Leu Glu Glu Leu Lys Lys Val Leu Gly Glu Lys Glu Thr Leu Leu Tyr 
        435                 440                 445             


Glu Asn Lys Gln Phe Glu Lys Ile Ala Glu Glu Leu Lys Gly Thr Glu 
    450                 455                 460                 


Gln Glu Leu Ile Gly Leu Leu Gln Ala Arg Glu Lys Glu Val His Asp 
465                 470                 475                 480 


Leu Glu Ile Gln Leu Thr Ala Ile Thr Thr Ser Glu Gln Tyr Tyr Ser 
                485                 490                 495     


Lys Glu Val Lys Asp Leu Lys Thr Glu Leu Glu Asn Glu Lys Leu Lys 
            500                 505                 510         


Asn Thr Glu Leu Thr Ser His Cys Asn Lys Leu Ser Leu Glu Asn Lys 
        515                 520                 525             


Glu Leu Thr Gln Glu Thr Ser Asp Met Thr Leu Glu Leu Lys Asn Gln 
    530                 535                 540                 


Gln Glu Asp Ile Asn Asn Asn Lys Lys Gln Glu Glu Arg Met Leu Lys 
545                 550                 555                 560 


Gln Ile Glu Asn Leu Gln Glu Thr Glu Thr Gln Leu Arg Asn Glu Leu 
                565                 570                 575     


Glu Tyr Val Arg Glu Glu Leu Lys Gln Lys Arg Asp Glu Val Lys Cys 
            580                 585                 590         


Lys Leu Asp Lys Ser Glu Glu Asn Cys Asn Asn Leu Arg Lys Gln Val 
        595                 600                 605             


Glu Asn Lys Asn Lys Tyr Ile Glu Glu Leu Gln Gln Glu Asn Lys Ala 
    610                 615                 620                 


Leu Lys Lys Lys Gly Thr Ala Glu Ser Lys Gln Leu Asn Val Tyr Glu 
625                 630                 635                 640 


Ile Lys Val Asn Lys Leu Glu Leu Glu Leu Glu Ser Ala Lys Gln Lys 
                645                 650                 655     


Phe Gly Glu Ile Thr Asp Thr Tyr Gln Lys Glu Ile Glu Asp Lys Lys 
            660                 665                 670         


Ile Ser Glu Glu Asn Leu Leu Glu Glu Val Glu Lys Ala Lys Val Ile 
        675                 680                 685             


Ala Asp Glu Ala Val Lys Leu Gln Lys Glu Ile Asp Lys Arg Cys Gln 
    690                 695                 700                 


His Lys Ile Ala Glu Met Val Ala Leu Met Glu Lys His Lys His Gln 
705                 710                 715                 720 


Tyr Asp Lys Ile Ile Glu Glu Arg Asp Ser Glu Leu Gly Leu Tyr Lys 
                725                 730                 735     


Ser Lys Glu Gln Glu Gln Ser Ser Leu Arg Ala Ser Leu Glu Ile Glu 
            740                 745                 750         


Leu Ser Asn Leu Lys Ala Glu Leu Leu Ser Val Lys Lys Gln Leu Glu 
        755                 760                 765             


Ile Glu Arg Glu Glu Lys Glu Lys Leu Lys Arg Glu Ala Lys Glu Asn 
    770                 775                 780                 


Thr Ala Thr Leu Lys Glu Lys Lys Asp Lys Lys Thr Gln Thr Phe Leu 
785                 790                 795                 800 


Leu Glu Thr Pro Glu Ile Tyr Trp Lys Leu Asp Ser Lys Ala Val Pro 
                805                 810                 815     


Ser Gln Thr Val Ser Arg Asn Phe Thr Ser Val Asp His Gly Ile Ser 
            820                 825                 830         


Lys Asp Lys Arg Asp Tyr Leu Trp Thr Ser Ala Lys Asn Thr Leu Ser 
        835                 840                 845             


Thr Pro Leu Pro Lys Ala Tyr Thr Val Lys Thr Pro Thr Lys Pro Lys 
    850                 855                 860                 


Leu Gln Gln Arg Glu Asn Leu Asn Ile Pro Ile Glu Glu Ser Lys Lys 
865                 870                 875                 880 


Lys Arg Lys Met Ala Phe Glu Phe Asp Ile Asn Ser Asp Ser Ser Glu 
                885                 890                 895     


Thr Thr Asp Leu Leu Ser Met Val Ser Glu Glu Glu Thr Leu Lys Thr 
            900                 905                 910         


Leu Tyr Arg Asn Asn Asn Pro Pro Ala Ser His Leu Cys Val Lys Thr 
        915                 920                 925             


Pro Lys Lys Ala Pro Ser Ser Leu Thr Thr Pro Gly Ser Thr Leu Lys 
    930                 935                 940                 


Phe Gly Ala Ile Arg Lys Met Arg Glu Asp Arg Trp Ala Val Ile Ala 
945                 950                 955                 960 


Lys Met Asp Arg Lys Lys Lys Leu Lys Glu Ala Glu Lys Leu Phe Val 
                965                 970                 975     






<210>  3556
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__AAI44020

<400>  3556
auggaaaagc aaaagcccuu ugcauuguuc guaccaccga gaucaagcag cagucaggug       60

ucugcgguga aaccucagac ccugggaggc gauuccacuu ucuucaagag uuucaacaaa      120

uguacugaag augauuuuga guuuccauuu gcaaagacua aucucuccaa aaauggggaa      180

aacauugauu cagauccugc uuuacaaaaa guuaauuucu ugcccguguu ugagcagguu      240

gguaauucug acugucacua ucaggaagga cuaaaagacu cugauuugga gaauucagag      300

ggauugagca gaguguauuc aaaacuguau aaggaggcug aaaagauaaa aaaauggaaa      360

guaaguacag aagcugaacu gagacagaaa gaaaguaagu ugcaagaaaa cagaaagaua      420

auugaagcac agcgaaaagc cauucaggaa cugcaauuug gaaaugaaaa aguaaguuug      480

aaauuagaag aaggaauaca agaaaauaaa gauuuaauaa aagagaauaa ugccacaagg      540

cauuuaugua aucuacucaa agaaaccugu gcuagaucug cagaaaagac aaagaaauau      600

gaauaugaac gggaagaaac caggcaaguu uauauggauc uaaauaguaa cauugagaaa      660

augauaacag cuuuugagga acuucgugug caagcugaga auuccagacu ggaaaugcau      720

uuuaaguuaa aggaagauua ugaaaaaauc caacaccuug aacaagaaua caagaaggaa      780

auaaaugaca aggaaaagca gguaucacua cuauugaucc aaaucacuga gaaagaaaau      840

aaaaugaaag auuuaacauu ucugcuagag gaauccagag auaaaguuaa ucaauuagag      900

gaaaagacaa aauuacagag ugaaaacuua aaacaaucaa uugagaaaca gcaucauuug      960

acuaaagaac uagaagauau uaaaguguca uuacaaagaa gugugaguac ucaaaaggcu     1020

uuagaggaag auuuacagau agcaacaaaa acaauuuguc agcuaacuga agaaaaagaa     1080

acucaaaugg aagaaucuaa uaaagcuaga gcugcucauu cguuuguggu uacugaauuu     1140

gaaacuacug ucugcagcuu ggaagaauua uugagaacag aacagcaaag auuggaaaaa     1200

aaugaagauc aauugaaaau acuuaccaug gagcuucaaa agaaaucaag ugagcuggaa     1260

gagaugacua agcuuacaaa uaacaaagaa guagaacuug aagaauugaa aaaagucuug     1320

ggagaaaagg aaacacuuuu auaugaaaau aaacaauuug agaagauugc ugaagaauua     1380

aaaggaacag aacaagaacu aauuggucuu cuccaagcca gagagaaaga aguacaugau     1440

uuggaaauac aguuaacugc cauuaccaca agugaacagu auuauucaaa agagguuaaa     1500

gaucuaaaaa cugagcuuga aaacgagaag cuuaagaaua cugaauuaac uucacacugc     1560

aacaagcuuu cacuagaaaa caaagagcuc acacaggaaa caagugauau gacccuagaa     1620

cucaagaauc agcaagaaga uauuaauaau aacaaaaagc aagaagaaag gauguugaaa     1680

caaauagaaa aucuucaaga aacagaaacc caauuaagaa augaacuaga auaugugaga     1740

gaagagcuaa aacagaaaag agaugaaguu aaauguaaau uggacaagag ugaagaaaau     1800

uguaacaauu uaaggaaaca aguugaaaau aaaaacaagu auauugaaga acuucagcag     1860

gagaauaagg ccuugaaaaa aaaagguaca gcagaaagca agcaacugaa uguuuaugag     1920

auaaagguca auaaauuaga guuagaacua gaaagugcca aacagaaauu uggagaaauc     1980

acagacaccu aucagaaaga aauugaggac aaaaagauau cagaagaaaa ucuuuuggaa     2040

gagguugaga aagcaaaagu aauagcugau gaagcaguaa aauuacagaa agaaauugau     2100

aagcgauguc aacauaaaau agcugaaaug guagcacuua uggaaaaaca uaagcaccaa     2160

uaugauaaga ucauugaaga aagagacuca gaauuaggac uuuauaagag caaagaacaa     2220

gaacagucau cacugagagc aucuuuggag auugaacuau ccaaucucaa agcugaacuu     2280

uugucuguua agaagcaacu ugaaauagaa agagaagaga aggaaaaacu caaaagagag     2340

gcaaaagaaa acacagcuac ucuuaaagaa aaaaaagaca agaaaacaca aacauuuuua     2400

uuggaaacac cugaaauuua uuggaaauug gauucuaaag caguuccuuc acaaacugua     2460

ucucgaaauu ucacaucagu ugaucauggc auauccaaag auaaaagaga cuaucugugg     2520

acaucugcca aaaauacuuu aucuacacca uugccaaagg cauauacagu gaagacacca     2580

acaaaaccaa aacuacagca aagagaaaac uugaauauac ccauugaaga aaguaaaaaa     2640

aagagaaaaa uggccuuuga auuugauauu aauucagaua guucagaaac uacugaucuu     2700

uugagcaugg uuucagaaga agagacauug aaaacacugu auaggaacaa uaauccacca     2760

gcuucucauc uuugugucaa aacaccaaaa aaggccccuu caucucuaac aaccccugga     2820

ucuacacuga aguuuggagc uauaagaaaa augcgggagg accguugggc uguaauugcu     2880

aaaauggaua gaaaaaaaaa acuaaaagaa gcugaaaagu uauuuguuua a              2931


<210>  3557
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYCP1__Homo_sapiens__AAI44020

<400>  3557
auggagaagc agaagcccuu cgcccuguuc gugccgcccc gcagcuccag cucccagguc       60

agcgccguga agccccagac ccucggcggg gacuccaccu ucuucaagag cuucaacaag      120

ugcacggagg acgacuucga guuccccuuc gcgaagacca accuguccaa gaacggcgag      180

aacaucgaca gcgacccggc ccugcagaag gugaacuucc uccccgucuu cgagcagguc      240

gggaacuccg acugccacua ccaggagggc cugaaggaca gcgaccugga gaacuccgag      300

gggcucagcc ggguguacuc caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu gcgccagaag gaguccaagc uccaggagaa ccggaagauc      420

aucgaggccc agcgcaaggc gauccaggag cugcaguucg gcaacgagaa ggugagccug      480

aagcucgagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccacccgg      540

caccugugca accuccugaa ggagacgugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gggaggagac ccgccaggug uacauggacc ugaacagcaa caucgagaag      660

augaucaccg cguucgagga gcuccggguc caggccgaga acucccgccu ggagaugcac      720

uucaagcuga aggaggacua cgagaagauc cagcaccucg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucagccug cugcucaucc agaucacgga gaaggagaac      840

aagaugaagg accugaccuu ccugcucgag gagagccggg acaaggugaa ccagcuggag      900

gagaagacca agcugcaguc cgagaaccuc aagcagagca ucgagaagca gcaccaccug      960

accaaggagc uggaggacau caaggugucc cuccagcgca gcguguccac gcagaaggcc     1020

cuggaggagg accugcagau cgccaccaag accaucugcc agcucaccga ggagaaggag     1080

acgcagaugg aggagagcaa caaggcccgg gcggcccacu ccuucguggu caccgaguuc     1140

gagaccaccg ugugcagccu ggaggagcug cuccgcacgg agcagcagcg gcuggagaag     1200

aacgaggacc agcugaagau ccucaccaug gagcugcaga agaaguccag cgagcuggag     1260

gagaugacca agcucaccaa caacaaggag guggagcugg aggagcugaa gaagguccuc     1320

ggggagaagg agacgcugcu guacgagaac aagcaguucg agaagaucgc cgaggagcug     1380

aagggcaccg agcaggagcu caucgggcug cugcaggccc gcgagaagga ggugcacgac     1440

cucgagaucc agcugaccgc caucaccacg uccgagcagu acuacagcaa ggaggugaag     1500

gaccugaaga ccgagcucga gaacgagaag cugaagaaca ccgagcugac cucccacugc     1560

aacaagcuca gccuggagaa caaggagcug acgcaggaga ccuccgacau gacccucgag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg gaugcugaag     1680

cagaucgaga accuccagga gaccgagacg cagcugcgca acgagcugga guacguccgg     1740

gaggagcuca agcagaagcg cgacgaggug aagugcaagc uggacaagag cgaggagaac     1800

ugcaacaacc ugcggaagca ggucgagaac aagaacaagu acaucgagga gcuccagcag     1860

gagaacaagg cgcugaagaa gaagggcacc gccgagucca agcagcugaa cguguacgag     1920

aucaagguga acaagcucga gcuggagcug gagagcgcca agcagaaguu cggggagauc     1980

accgacaccu accagaagga gaucgaggac aagaagaucu ccgaggagaa ccuccuggag     2040

gaggucgaga aggccaaggu gaucgccgac gaggcgguga agcugcagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuca uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacagc gagcugggcc uguacaagag caaggagcag     2220

gagcagucca gccuccgggc cucccuggag aucgagcuga gcaaccucaa ggccgagcug     2280

cuguccguga agaagcagcu cgagaucgag cgcgaggaga aggagaagcu gaagcgggag     2340

gcgaaggaga acaccgccac gcugaaggag aagaaggaca agaagaccca gaccuuccuc     2400

cuggagaccc ccgagaucua cuggaagcug gacagcaagg ccgugcccuc ccagacgguc     2460

agccgcaacu ucaccuccgu ggaccacggc aucagcaagg acaagcggga cuaccucugg     2520

accuccgcca agaacacccu gagcacgccg cugcccaagg cguacaccgu gaagaccccc     2580

accaagccca agcuccagca gcgcgagaac cugaacaucc cgaucgagga guccaagaag     2640

aagcggaaga uggccuucga guucgacauc aacagcgacu ccagcgagac gaccgaccug     2700

cucuccaugg ucagcgagga ggagacccug aagacccugu accgcaacaa caacccgccc     2760

gccagccacc ucugcgugaa gacgcccaag aaggcccccu ccagccugac cacccccggg     2820

uccacccuga aguucggcgc cauccggaag augcgcgagg accggugggc ggugaucgcc     2880

aagauggacc gcaagaagaa gcucaaggag gccgagaagc uguucgucug a              2931


<210>  3558
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYCP1__Homo_sapiens__AAI44020

<400>  3558
auggagaagc agaagcccuu cgcccucuuc gucccccccc gcuccuccuc cucccagguc       60

uccgccguca agccccagac ccucggcggc gacuccaccu ucuucaaguc cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accucuccaa gaacggcgag      180

aacaucgacu ccgaccccgc ccuccagaag gucaacuucc uccccgucuu cgagcagguc      240

ggcaacuccg acugccacua ccaggagggc cucaaggacu ccgaccucga gaacuccgag      300

ggccucuccc gcgucuacuc caagcucuac aaggaggccg agaagaucaa gaaguggaag      360

gucuccaccg aggccgagcu ccgccagaag gaguccaagc uccaggagaa ccgcaagauc      420

aucgaggccc agcgcaaggc cauccaggag cuccaguucg gcaacgagaa ggucucccuc      480

aagcucgagg agggcaucca ggagaacaag gaccucauca aggagaacaa cgccacccgc      540

caccucugca accuccucaa ggagaccugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gcgaggagac ccgccagguc uacauggacc ucaacuccaa caucgagaag      660

augaucaccg ccuucgagga gcuccgcguc caggccgaga acucccgccu cgagaugcac      720

uucaagcuca aggaggacua cgagaagauc cagcaccucg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucucccuc cuccucaucc agaucaccga gaaggagaac      840

aagaugaagg accucaccuu ccuccucgag gagucccgcg acaaggucaa ccagcucgag      900

gagaagacca agcuccaguc cgagaaccuc aagcagucca ucgagaagca gcaccaccuc      960

accaaggagc ucgaggacau caaggucucc cuccagcgcu ccgucuccac ccagaaggcc     1020

cucgaggagg accuccagau cgccaccaag accaucugcc agcucaccga ggagaaggag     1080

acccagaugg aggaguccaa caaggcccgc gccgcccacu ccuucgucgu caccgaguuc     1140

gagaccaccg ucugcucccu cgaggagcuc cuccgcaccg agcagcagcg ccucgagaag     1200

aacgaggacc agcucaagau ccucaccaug gagcuccaga agaaguccuc cgagcucgag     1260

gagaugacca agcucaccaa caacaaggag gucgagcucg aggagcucaa gaagguccuc     1320

ggcgagaagg agacccuccu cuacgagaac aagcaguucg agaagaucgc cgaggagcuc     1380

aagggcaccg agcaggagcu caucggccuc cuccaggccc gcgagaagga gguccacgac     1440

cucgagaucc agcucaccgc caucaccacc uccgagcagu acuacuccaa ggaggucaag     1500

gaccucaaga ccgagcucga gaacgagaag cucaagaaca ccgagcucac cucccacugc     1560

aacaagcucu cccucgagaa caaggagcuc acccaggaga ccuccgacau gacccucgag     1620

cucaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg caugcucaag     1680

cagaucgaga accuccagga gaccgagacc cagcuccgca acgagcucga guacguccgc     1740

gaggagcuca agcagaagcg cgacgagguc aagugcaagc ucgacaaguc cgaggagaac     1800

ugcaacaacc uccgcaagca ggucgagaac aagaacaagu acaucgagga gcuccagcag     1860

gagaacaagg cccucaagaa gaagggcacc gccgagucca agcagcucaa cgucuacgag     1920

aucaagguca acaagcucga gcucgagcuc gaguccgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagaucu ccgaggagaa ccuccucgag     2040

gaggucgaga aggccaaggu caucgccgac gaggccguca agcuccagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuca uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacucc gagcucggcc ucuacaaguc caaggagcag     2220

gagcaguccu cccuccgcgc cucccucgag aucgagcucu ccaaccucaa ggccgagcuc     2280

cucuccguca agaagcagcu cgagaucgag cgcgaggaga aggagaagcu caagcgcgag     2340

gccaaggaga acaccgccac ccucaaggag aagaaggaca agaagaccca gaccuuccuc     2400

cucgagaccc ccgagaucua cuggaagcuc gacuccaagg ccguccccuc ccagaccguc     2460

ucccgcaacu ucaccuccgu cgaccacggc aucuccaagg acaagcgcga cuaccucugg     2520

accuccgcca agaacacccu cuccaccccc cuccccaagg ccuacaccgu caagaccccc     2580

accaagccca agcuccagca gcgcgagaac cucaacaucc ccaucgagga guccaagaag     2640

aagcgcaaga uggccuucga guucgacauc aacuccgacu ccuccgagac caccgaccuc     2700

cucuccaugg ucuccgagga ggagacccuc aagacccucu accgcaacaa caaccccccc     2760

gccucccacc ucugcgucaa gacccccaag aaggcccccu ccucccucac cacccccggc     2820

uccacccuca aguucggcgc cauccgcaag augcgcgagg accgcugggc cgucaucgcc     2880

aagauggacc gcaagaagaa gcucaaggag gccgagaagc ucuucgucug a              2931


<210>  3559
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYCP1__Homo_sapiens__AAI44020

<400>  3559
auggagaagc agaagcccuu cgcccuguuu gugccuccaa gaagcuccuc uucacaaguc       60

agugcuguua agccgcagac ccucggcggg gacagcacau ucuuuaaauc cuucaacaag      120

ugcacugaag augacuuuga guuccccuuu gcaaaaacga accuuucuaa gaacggagaa      180

aauaucgauu cggacccugc ccugcagaag gugaacuucu ugccaguauu ugaacaggug      240

gguaauucag auugucacua ccaagaaggc uuaaaagaca gcgaucugga gaacagugag      300

gggcuaucca gggucuauuc uaagcucuac aaagaagcgg agaagauuaa aaaguggaag      360

gugagcaccg aagcugagcu gcggcagaaa gaguccaaac uucaggaaaa ucgcaaaaua      420

aucgaggccc agcgaaaggc aauucaagaa cugcaguucg gaaacgagaa aguuucauug      480

aagcucgaag agggcaucca ggagaauaaa gaccugauua aggaaaacaa ugccacacgu      540

caucugugca accucuuaaa ggagacuugu gcuagaagug cagaaaagac caagaaauau      600

gaguacgaaa gggaggagac acgccaggug uauauggauc ugaauagcaa caucgaaaag      660

augauaaccg ccuuugagga acuucggguc caagcugaaa auucuagauu ggaaaugcac      720

uucaaacuga aggaggacua cgagaagauc cagcaucuag aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca agugucccuc cugcuuaucc agauuacuga gaaagaaaac      840

aagaugaagg accugacauu uuugcucgag gaaucaaggg auaaaguaaa ucagcuggag      900

gaaaagacca aauuacagag cgagaaccug aagcaaagua ucgagaaaca gcaccaucuc      960

acgaaggaac uugaggacau aaagguuucu cugcagcggu ccgugagcac ucagaaagcc     1020

uuggaagagg accuacaaau ugcgaccaag acaaucugcc agcugacuga agagaaagag     1080

acccagaugg aagagucgaa uaaggcacgc gccgcucacu cuuucgucgu gacagaguuc     1140

gagaccacgg uguguucccu cgaggagcug cuucgaacug agcagcaaag acuggaaaag     1200

aacgaggauc aguugaagau ucucacaaug gaacugcaga aaaagucaag ugaguuagag     1260

gaaaugacca agcugacuaa uaacaaagag gucgaacuag aggaacucaa gaaaguucug     1320

ggugagaagg agacacuuuu guacgaaaau aaacaguuug agaagaucgc cgaggaacug     1380

aaggggaccg aacaagagcu caucggacug cuucaggcaa gggagaaaga agugcacgac     1440

cuggagauuc aguugacggc uauaaccaca agcgaacaau acuauuccaa ggagguaaaa     1500

gaucucaaga cugaacugga gaacgagaaa uuaaagaaua ccgaacugac aucucauugc     1560

aacaagcuaa gccucgagaa uaaagaacug acucaggaga ccucagacau gacacuugag     1620

uugaagaacc agcaggaaga uaucaauaac aauaaaaagc aagaggaacg gaugcugaaa     1680

cagauugaga accuccagga aaccgagacu cagcugcgua acgaguuaga auacgugcgc     1740

gaggaacuga agcaaaagag agacgagguc aaauguaaac uugauaaaag ugaagagaau     1800

ugcaacaauu ugaggaaaca gguggagaac aaaaauaagu auaucgagga acuccagcag     1860

gaaaacaaag cccugaagaa gaaaggcacg gcggagucca agcaacuaaa uguuuacgaa     1920

auaaaaguga acaagcugga gcucgagcug gaaagcgcca aacagaaguu cggcgagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagaucu cugaggaaaa ucuuuuggag     2040

gaagucgaga aagcaaaggu gauugcugac gaagccguaa aacugcaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug guugccuuaa uggaaaagca uaaacaccag     2160

uacgacaaga uaaucgagga acgagacuca gagcucgggc uguauaaaag uaaggaacag     2220

gagcaaagcu cccuucgcgc aucucuggag auugaauugu cgaaccucaa ggccgagcug     2280

cuaagcguga aaaagcagcu ggaaaucgag agagaagaga aagagaagcu caaaagggaa     2340

gcuaaggaga auacugcgac ccugaaggaa aagaaggaua aaaagacaca gaccuuucuu     2400

uuggagacuc ccgagaucua cuggaaacug gacuccaagg cagucccuuc acagacagug     2460

agucggaacu ucacgucugu cgaucacgga auuagcaaag acaagcgcga uuacuuaugg     2520

accuccgcca agaauacucu cucaacacca cugcccaagg cuuauaccgu gaagacaccu     2580

acuaaaccaa aacuucaaca gagagaaaac cugaauauac cgaucgagga aagcaaaaag     2640

aagaggaaaa uggccuuuga guucgacauu aacucugauu ccagugaaac cacggaccua     2700

cucagcaugg uuucugagga ggaaacccug aagacauugu accguaacaa uaaucccccu     2760

gcaucccauc ugugcgugaa aacuccaaag aaagcccccu caaguuuaac cacaccuggu     2820

agcacucuca aguuuggcgc uauccggaag augcgagagg auagaugggc cguaauugca     2880

aaaauggaca ggaagaaaaa gcugaaagaa gcggagaaac uuuucgucug a              2931


<210>  3560
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYCP1__Homo_sapiens__AAI44020

<400>  3560
auggagaagc agaagcccuu cgcccuguuc gugcccccca gaagcagcag cagccaggug       60

agcgccguga agccccagac ccugggcggc gacagcaccu ucuucaagag cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accugagcaa gaacggcgag      180

aacaucgaca gcgaccccgc ccugcagaag gugaacuucc ugcccguguu cgagcaggug      240

ggcaacagcg acugccacua ccaggagggc cugaaggaca gcgaccugga gaacagcgag      300

ggccugagca gaguguacag caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu gagacagaag gagagcaagc ugcaggagaa cagaaagauc      420

aucgaggccc agagaaaggc cauccaggag cugcaguucg gcaacgagaa ggugagccug      480

aagcuggagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccaccaga      540

caccugugca accugcugaa ggagaccugc gccagaagcg ccgagaagac caagaaguac      600

gaguacgaga gagaggagac cagacaggug uacauggacc ugaacagcaa caucgagaag      660

augaucaccg ccuucgagga gcugagagug caggccgaga acagcagacu ggagaugcac      720

uucaagcuga aggaggacua cgagaagauc cagcaccugg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggugagccug cugcugaucc agaucaccga gaaggagaac      840

aagaugaagg accugaccuu ccugcuggag gagagcagag acaaggugaa ccagcuggag      900

gagaagacca agcugcagag cgagaaccug aagcagagca ucgagaagca gcaccaccug      960

accaaggagc uggaggacau caaggugagc cugcagagaa gcgugagcac ccagaaggcc     1020

cuggaggagg accugcagau cgccaccaag accaucugcc agcugaccga ggagaaggag     1080

acccagaugg aggagagcaa caaggccaga gccgcccaca gcuucguggu gaccgaguuc     1140

gagaccaccg ugugcagccu ggaggagcug cugagaaccg agcagcagag acuggagaag     1200

aacgaggacc agcugaagau ccugaccaug gagcugcaga agaagagcag cgagcuggag     1260

gagaugacca agcugaccaa caacaaggag guggagcugg aggagcugaa gaaggugcug     1320

ggcgagaagg agacccugcu guacgagaac aagcaguucg agaagaucgc cgaggagcug     1380

aagggcaccg agcaggagcu gaucggccug cugcaggcca gagagaagga ggugcacgac     1440

cuggagaucc agcugaccgc caucaccacc agcgagcagu acuacagcaa ggaggugaag     1500

gaccugaaga ccgagcugga gaacgagaag cugaagaaca ccgagcugac cagccacugc     1560

aacaagcuga gccuggagaa caaggagcug acccaggaga ccagcgacau gacccuggag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagag aaugcugaag     1680

cagaucgaga accugcagga gaccgagacc cagcugagaa acgagcugga guacgugaga     1740

gaggagcuga agcagaagag agacgaggug aagugcaagc uggacaagag cgaggagaac     1800

ugcaacaacc ugagaaagca gguggagaac aagaacaagu acaucgagga gcugcagcag     1860

gagaacaagg cccugaagaa gaagggcacc gccgagagca agcagcugaa cguguacgag     1920

aucaagguga acaagcugga gcuggagcug gagagcgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagauca gcgaggagaa ccugcuggag     2040

gagguggaga aggccaaggu gaucgccgac gaggccguga agcugcagaa ggagaucgac     2100

aagagaugcc agcacaagau cgccgagaug guggcccuga uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gagagacagc gagcugggcc uguacaagag caaggagcag     2220

gagcagagca gccugagagc cagccuggag aucgagcuga gcaaccugaa ggccgagcug     2280

cugagcguga agaagcagcu ggagaucgag agagaggaga aggagaagcu gaagagagag     2340

gccaaggaga acaccgccac ccugaaggag aagaaggaca agaagaccca gaccuuccug     2400

cuggagaccc ccgagaucua cuggaagcug gacagcaagg ccgugcccag ccagaccgug     2460

agcagaaacu ucaccagcgu ggaccacggc aucagcaagg acaagagaga cuaccugugg     2520

accagcgcca agaacacccu gagcaccccc cugcccaagg ccuacaccgu gaagaccccc     2580

accaagccca agcugcagca gagagagaac cugaacaucc ccaucgagga gagcaagaag     2640

aagagaaaga uggccuucga guucgacauc aacagcgaca gcagcgagac caccgaccug     2700

cugagcaugg ugagcgagga ggagacccug aagacccugu acagaaacaa caaccccccc     2760

gccagccacc ugugcgugaa gacccccaag aaggccccca gcagccugac cacccccggc     2820

agcacccuga aguucggcgc caucagaaag augagagagg acagaugggc cgugaucgcc     2880

aagauggaca gaaagaagaa gcugaaggag gccgagaagc uguucgugug a              2931


<210>  3561
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYCP1__Homo_sapiens__AAI44020

<400>  3561
auggagaagc agaaacccuu cgcccuguuu gugccuccga gaagcuccuc uagccaaguc       60

uccgcuguua agccccagac ccucggcggg gacucuacau ucuuuaagag cuucaacaag      120

ugcacggaag augacuuuga guucccuuuu gccaaaacca accuguccaa gaacggagaa      180

aauaucgauu cugaccccgc gcuucagaag gugaacuucc ugccuguguu ugagcagguc      240

ggcaauagcg auugucacua ccaagaaggg cucaaagacu ccgaucugga gaacagcgag      300

ggacuuucuc ggguguauuc caagcuguac aaagaagcug agaagauuaa aaaguggaag      360

guuagcacag aagccgagcu ccgccagaaa gagucuaagc ugcaggaaaa uagaaaaauc      420

auugaggccc agcggaaggc uauccaagaa cugcaguucg gcaacgagaa agugucccuc      480

aagcuggaag aggggauuca ggagaauaaa gaccuuauca aggaaaacaa ugccacccgc      540

caucugugca accuccugaa ggagacaugu gcuagaagcg ccgagaaaac caagaaauau      600

gaguacgaac gggaggagac acgccagguc uauauggauc uuaauucuaa caucgaaaag      660

augauuaccg cguuugagga acugagagug caagccgaaa auucccggcu cgaaaugcac      720

uucaaacuga aggaggacua cgagaagauc cagcaucugg aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca aguuagccuc cugcuuaucc agauuacgga gaaagaaaac      840

aagaugaagg accugaccuu ucuccuggag gaaucccgcg auaaagugaa ucagcuugag      900

gaaaagacaa aacugcaguc ugagaaccuc aagcaaagca ucgagaaaca gcaccaucug      960

accaaggaac uggaggacau uaaggucucc cuccagagaa gcgugucuac acagaaagcu     1020

cuggaagagg accuucaaau cgccaccaag acgaucugcc agcugacaga agagaaagag     1080

acccagaugg aagaguccaa uaaggcucgg gccgcgcaca gcuucguggu cacagaguuc     1140

gaaaccaccg uuuguucucu cgaggaacug cuucgcacag agcagcaaag acuggagaaa     1200

aacgaagauc agcucaagau ucugacgaug gaacugcaga aaaagagcuc cgagcucgag     1260

gaaaugacca agcugacaaa uaacaaagag guggaacuug aggaacugaa gaaagugcuc     1320

ggagagaagg agacccugcu guacgaaaau aaacaguuug agaagaucgc cgaggaacuu     1380

aagggcacag aacaagagcu cauuggccug cugcaggcuc gggagaaaga aguccacgac     1440

cucgagaucc agcugaccgc cauuacgaca ucugaacaau acuauagcaa ggaggugaaa     1500

gaucuuaaga ccgaacugga gaacgagaaa cucaagaaua ccgaacugac aucccauugc     1560

aacaagcuga gccuugagaa uaaagaacuc acccaggaga caucugacau gacgcuggag     1620

cugaagaacc agcaggaaga uaucaauaac aauaaaaagc aagaggaacg caugcucaaa     1680

cagaucgaga accugcagga aaccgagaca cagcuuagaa acgagcugga auacguucgg     1740

gaggaacuca agcaaaagag agacgaggug aaauguaagc uggauaaauc cgaagagaau     1800

ugcaacaauc ugcgcaagca ggucgagaac aaaaauaagu auauugagga acuucagcag     1860

gaaaacaaag cucucaagaa gaaagggacc gccgagagca agcaacugaa uguguacgaa     1920

aucaaaguua acaagcugga gcucgagcug gaaucugcca aacagaaguu cggagagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagauuu ccgaggaaaa ucuucuggag     2040

gaaguggaga aagcuaaggu caucgcggac gaagccguga aacuccaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug gucgcccuga uggaaaagca uaaacaccag     2160

uacgacaaga ucauugagga aagagacagc gagcugggcc uuuauaaauc caaggaacag     2220

gagcaaucua gccuccgcgc cucccuggag aucgaacugu cuaaccucaa ggcugagcug     2280

cuuagcguga aaaagcagcu ggaaauugag cgggaagaga aagagaagcu caaaagagaa     2340

gccaaggaga auacggcgac ccugaaggag aaaaaggaua aaaagacaca gaccuuucug     2400

cuugaaacac ccgagaucua cuggaaacug gacuccaagg cuguuccuag ccagaccgug     2460

ucucgcaacu ucacguccgu cgaucacggg auuagcaaag acaagcggga uuaccucugg     2520

acaucugcca agaauacccu guccacaccg cuccccaaag ccuauaccgu gaagaccccu     2580

acaaaaccca agcugcaaca gagagaaaac cuuaauaucc cuaucgagga aagcaaaaag     2640

aagcgcaaaa uggcuuuuga guucgacauu aacucugaua gcuccgaaac gaccgaccug     2700

cucagcaugg uuucugagga ggaaacacug aagacccugu accggaacaa uaaucccccg     2760

gccucccauc uuugcgugaa aacaccuaag aaagcuccca gcucccugac cacgccugga     2820

ucuacacuca aguuuggcgc caucagaaag augcgcgagg aucggugggc ggucauugcc     2880

aaaauggaca gaaagaaaaa gcugaaagaa gcugagaaac ucuucgugug a              2931


<210>  3562
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__Q15431

<400>  3562

Met Glu Lys Gln Lys Pro Phe Ala Leu Phe Val Pro Pro Arg Ser Ser 
1               5                   10                  15      


Ser Ser Gln Val Ser Ala Val Lys Pro Gln Thr Leu Gly Gly Asp Ser 
            20                  25                  30          


Thr Phe Phe Lys Ser Phe Asn Lys Cys Thr Glu Asp Asp Phe Glu Phe 
        35                  40                  45              


Pro Phe Ala Lys Thr Asn Leu Ser Lys Asn Gly Glu Asn Ile Asp Ser 
    50                  55                  60                  


Asp Pro Ala Leu Gln Lys Val Asn Phe Leu Pro Val Leu Glu Gln Val 
65                  70                  75                  80  


Gly Asn Ser Asp Cys His Tyr Gln Glu Gly Leu Lys Asp Ser Asp Leu 
                85                  90                  95      


Glu Asn Ser Glu Gly Leu Ser Arg Val Tyr Ser Lys Leu Tyr Lys Glu 
            100                 105                 110         


Ala Glu Lys Ile Lys Lys Trp Lys Val Ser Thr Glu Ala Glu Leu Arg 
        115                 120                 125             


Gln Lys Glu Ser Lys Leu Gln Glu Asn Arg Lys Ile Ile Glu Ala Gln 
    130                 135                 140                 


Arg Lys Ala Ile Gln Glu Leu Gln Phe Gly Asn Glu Lys Val Ser Leu 
145                 150                 155                 160 


Lys Leu Glu Glu Gly Ile Gln Glu Asn Lys Asp Leu Ile Lys Glu Asn 
                165                 170                 175     


Asn Ala Thr Arg His Leu Cys Asn Leu Leu Lys Glu Thr Cys Ala Arg 
            180                 185                 190         


Ser Ala Glu Lys Thr Lys Lys Tyr Glu Tyr Glu Arg Glu Glu Thr Arg 
        195                 200                 205             


Gln Val Tyr Met Asp Leu Asn Asn Asn Ile Glu Lys Met Ile Thr Ala 
    210                 215                 220                 


Phe Glu Glu Leu Arg Val Gln Ala Glu Asn Ser Arg Leu Glu Met His 
225                 230                 235                 240 


Phe Lys Leu Lys Glu Asp Tyr Glu Lys Ile Gln His Leu Glu Gln Glu 
                245                 250                 255     


Tyr Lys Lys Glu Ile Asn Asp Lys Glu Lys Gln Val Ser Leu Leu Leu 
            260                 265                 270         


Ile Gln Ile Thr Glu Lys Glu Asn Lys Met Lys Asp Leu Thr Phe Leu 
        275                 280                 285             


Leu Glu Glu Ser Arg Asp Lys Val Asn Gln Leu Glu Glu Lys Thr Lys 
    290                 295                 300                 


Leu Gln Ser Glu Asn Leu Lys Gln Ser Ile Glu Lys Gln His His Leu 
305                 310                 315                 320 


Thr Lys Glu Leu Glu Asp Ile Lys Val Ser Leu Gln Arg Ser Val Ser 
                325                 330                 335     


Thr Gln Lys Ala Leu Glu Glu Asp Leu Gln Ile Ala Thr Lys Thr Ile 
            340                 345                 350         


Cys Gln Leu Thr Glu Glu Lys Glu Thr Gln Met Glu Glu Ser Asn Lys 
        355                 360                 365             


Ala Arg Ala Ala His Ser Phe Val Val Thr Glu Phe Glu Thr Thr Val 
    370                 375                 380                 


Cys Ser Leu Glu Glu Leu Leu Arg Thr Glu Gln Gln Arg Leu Glu Lys 
385                 390                 395                 400 


Asn Glu Asp Gln Leu Lys Ile Leu Thr Met Glu Leu Gln Lys Lys Ser 
                405                 410                 415     


Ser Glu Leu Glu Glu Met Thr Lys Leu Thr Asn Asn Lys Glu Val Glu 
            420                 425                 430         


Leu Glu Glu Leu Lys Lys Val Leu Gly Glu Lys Glu Thr Leu Leu Tyr 
        435                 440                 445             


Glu Asn Lys Gln Phe Glu Lys Ile Ala Glu Glu Leu Lys Gly Thr Glu 
    450                 455                 460                 


Gln Glu Leu Ile Gly Leu Leu Gln Ala Arg Glu Lys Glu Val His Asp 
465                 470                 475                 480 


Leu Glu Ile Gln Leu Thr Ala Ile Thr Thr Ser Glu Gln Tyr Tyr Ser 
                485                 490                 495     


Lys Glu Val Lys Asp Leu Lys Thr Glu Leu Glu Asn Glu Lys Leu Lys 
            500                 505                 510         


Asn Thr Glu Leu Thr Ser His Cys Asn Lys Leu Ser Leu Glu Asn Lys 
        515                 520                 525             


Glu Leu Thr Gln Glu Thr Ser Asp Met Thr Leu Glu Leu Lys Asn Gln 
    530                 535                 540                 


Gln Glu Asp Ile Asn Asn Asn Lys Lys Gln Glu Glu Arg Met Leu Lys 
545                 550                 555                 560 


Gln Ile Glu Asn Leu Gln Glu Thr Glu Thr Gln Leu Arg Asn Glu Leu 
                565                 570                 575     


Glu Tyr Val Arg Glu Glu Leu Lys Gln Lys Arg Asp Glu Val Lys Cys 
            580                 585                 590         


Lys Leu Asp Lys Ser Glu Glu Asn Cys Asn Asn Leu Arg Lys Gln Val 
        595                 600                 605             


Glu Asn Lys Asn Lys Tyr Ile Glu Glu Leu Gln Gln Glu Asn Lys Ala 
    610                 615                 620                 


Leu Lys Lys Lys Gly Thr Ala Glu Ser Lys Gln Leu Asn Val Tyr Glu 
625                 630                 635                 640 


Ile Lys Val Asn Lys Leu Glu Leu Glu Leu Glu Ser Ala Lys Gln Lys 
                645                 650                 655     


Phe Gly Glu Ile Thr Asp Thr Tyr Gln Lys Glu Ile Glu Asp Lys Lys 
            660                 665                 670         


Ile Ser Glu Glu Asn Leu Leu Glu Glu Val Glu Lys Ala Lys Val Ile 
        675                 680                 685             


Ala Asp Glu Ala Val Lys Leu Gln Lys Glu Ile Asp Lys Arg Cys Gln 
    690                 695                 700                 


His Lys Ile Ala Glu Met Val Ala Leu Met Glu Lys His Lys His Gln 
705                 710                 715                 720 


Tyr Asp Lys Ile Ile Glu Glu Arg Asp Ser Glu Leu Gly Leu Tyr Lys 
                725                 730                 735     


Ser Lys Glu Gln Glu Gln Ser Ser Leu Arg Ala Ser Leu Glu Ile Glu 
            740                 745                 750         


Leu Ser Asn Leu Lys Ala Glu Leu Leu Ser Val Lys Lys Gln Leu Glu 
        755                 760                 765             


Ile Glu Arg Glu Glu Lys Glu Lys Leu Lys Arg Glu Ala Lys Glu Asn 
    770                 775                 780                 


Thr Ala Thr Leu Lys Glu Lys Lys Asp Lys Lys Thr Gln Thr Phe Leu 
785                 790                 795                 800 


Leu Glu Thr Pro Glu Ile Tyr Trp Lys Leu Asp Ser Lys Ala Val Pro 
                805                 810                 815     


Ser Gln Thr Val Ser Arg Asn Phe Thr Ser Val Asp His Gly Ile Ser 
            820                 825                 830         


Lys Asp Lys Arg Asp Tyr Leu Trp Thr Ser Ala Lys Asn Thr Leu Ser 
        835                 840                 845             


Thr Pro Leu Pro Lys Ala Tyr Thr Val Lys Thr Pro Thr Lys Pro Lys 
    850                 855                 860                 


Leu Gln Gln Arg Glu Asn Leu Asn Ile Pro Ile Glu Glu Ser Lys Lys 
865                 870                 875                 880 


Lys Arg Lys Met Ala Phe Glu Phe Asp Ile Asn Ser Asp Ser Ser Glu 
                885                 890                 895     


Thr Thr Asp Leu Leu Ser Met Val Ser Glu Glu Glu Thr Leu Lys Thr 
            900                 905                 910         


Leu Tyr Arg Asn Asn Asn Pro Pro Ala Ser His Leu Cys Val Lys Thr 
        915                 920                 925             


Pro Lys Lys Ala Pro Ser Ser Leu Thr Thr Pro Gly Ser Thr Leu Lys 
    930                 935                 940                 


Phe Gly Ala Ile Arg Lys Met Arg Glu Asp Arg Trp Ala Val Ile Ala 
945                 950                 955                 960 


Lys Met Asp Arg Lys Lys Lys Leu Lys Glu Ala Glu Lys Leu Phe Val 
                965                 970                 975     






<210>  3563
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__AAI26267

<400>  3563
auggaaaagc aaaagcccuu ugcauuguuc guaccaccga gaucaagcag cagucaggug       60

ucugcgguga aaccucagac ccugggaggc gauuccacuu ucuucaagag uuucaacaaa      120

uguacugaag augauuuuga guuuccauuu gcaaagacua aucucuccaa aaauggggaa      180

aacauugauu cagauccugc uuuacaaaaa guuaauuucu ugcccgugcu ugagcagguu      240

gguaauucug acugucacua ucaggaagga cuaaaagacu cugauuugga gaauucagag      300

ggauugagca gaguguauuc aaaacuguau aaggaggcug aaaagauaaa aaaauggaaa      360

guaaguacag aagcugaacu gagacagaaa gaaaguaagu ugcaagaaaa cagaaagaua      420

auugaagcac agcgaaaagc cauucaggaa cugcaauuug gaaaugaaaa aguaaguuug      480

aaauuagaag aaggaauaca agaaaauaaa gauuuaauaa aagagaauaa ugccacaagg      540

cauuuaugua aucuacucaa agaaaccugu gcuagaucug cagaaaagac aaagaaauau      600

gaauaugaac gggaagaaac caggcaaguu uauauggauc uaaauaauaa cauugagaaa      660

augauaacag cuuuugagga acuucgugug caagcugaga auuccagacu ggaaaugcau      720

uuuaaguuaa aggaagauua ugaaaaaauc caacaccuug aacaagaaua caagaaggaa      780

auaaaugaca aggaaaagca gguaucacua cuauugaucc aaaucacuga gaaagaaaau      840

aaaaugaaag auuuaacauu ucugcuagag gaauccagag auaaaguuaa ucaauuagag      900

gaaaagacaa aauuacagag ugaaaacuua aaacaaucaa uugagaaaca gcaucauuug      960

acuaaagaac uagaagauau uaaaguguca uuacaaagaa gugugaguac ucaaaaggcu     1020

uuagaggaag auuuacagau agcaacaaaa acaauuuguc agcuaacuga agaaaaagaa     1080

acucaaaugg aagaaucuaa uaaagcuaga gcugcucauu cguuuguggu uacugaauuu     1140

gaaacuacug ucugcagcuu ggaagaauua uugagaacag aacagcaaag auuggaaaaa     1200

aaugaagauc aauugaaaau acuuaccaug gagcuucaaa agaaaucaag ugagcuggaa     1260

gagaugacua agcuuacaaa uaacaaagaa guagaacuug aagaauugaa aaaagucuug     1320

ggagaaaagg aaacacuuuu auaugaaaau aaacaauuug agaagauugc ugaagaauua     1380

aaaggaacag aacaagaacu aauuggucuu cuccaagcca gagagaaaga aguacaugau     1440

uuggaaauac aguuaacugc cauuaccaca agugaacagu auuauucaaa agagguuaaa     1500

gaucuaaaaa cugagcuuga aaacgagaag cuuaagaaua cugaauuaac uucacacugc     1560

aacaagcuuu cacuagaaaa caaagagcuc acacaggaaa caagugauau gacccuagaa     1620

cucaagaauc agcaagaaga uauuaauaau aacaaaaagc aagaagaaag gauguugaaa     1680

caaauagaaa aucuucaaga aacagaaacc caauuaagaa augaacuaga auaugugaga     1740

gaagagcuaa aacagaaaag agaugaaguu aaauguaaau uggacaagag ugaagaaaau     1800

uguaacaauu uaaggaaaca aguugaaaau aaaaacaagu auauugaaga acuucagcag     1860

gagaauaagg ccuugaaaaa aaaagguaca gcagaaagca agcaacugaa uguuuaugag     1920

auaaagguca auaaauuaga guuagaacua gaaagugcca aacagaaauu uggagaaauc     1980

acagacaccu aucagaaaga aauugaggac aaaaagauau cagaagaaaa ucuuuuggaa     2040

gagguugaga aagcaaaagu aauagcugau gaagcaguaa aauuacagaa agaaauugau     2100

aagcgauguc aacauaaaau agcugaaaug guagcacuua uggaaaaaca uaagcaccaa     2160

uaugauaaga ucauugaaga aagagacuca gaauuaggac uuuauaagag caaagaacaa     2220

gaacagucau cacugagagc aucuuuggag auugaacuau ccaaucucaa agcugaacuu     2280

uugucuguua agaagcaacu ugaaauagaa agagaagaga aggaaaaacu caaaagagag     2340

gcaaaagaaa acacagcuac ucuuaaagaa aaaaaagaca agaaaacaca aacauuuuua     2400

uuggaaacac cugaaauuua uuggaaauug gauucuaaag caguuccuuc acaaacugua     2460

ucucgaaauu ucacaucagu ugaucauggc auauccaaag auaaaagaga cuaucugugg     2520

acaucugcca aaaauacuuu aucuacacca uugccaaagg cauauacagu gaagacacca     2580

acaaaaccaa aacuacagca aagagaaaac uugaauauac ccauugaaga aaguaaaaaa     2640

aagagaaaaa uggccuuuga auuugauauu aauucagaua guucagaaac uacugaucuu     2700

uugagcaugg uuucagaaga agagacauug aaaacacugu auaggaacaa uaauccacca     2760

gcuucucauc uuugugucaa aacaccaaaa aaggccccuu caucucuaac aaccccugga     2820

ucuacacuga aguuuggagc uauaagaaaa augcgggagg accguugggc uguaauugcu     2880

aaaauggaua gaaaaaaaaa acuaaaagaa gcugaaaagu uauuuguuua a              2931


<210>  3564
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYCP1__Homo_sapiens__AAI26267

<400>  3564
auggagaagc agaagcccuu cgcccuguuc gugccgcccc gcagcuccag cucccagguc       60

agcgccguga agccccagac ccucggcggg gacuccaccu ucuucaagag cuucaacaag      120

ugcacggagg acgacuucga guuccccuuc gcgaagacca accuguccaa gaacggcgag      180

aacaucgaca gcgacccggc ccugcagaag gugaacuucc uccccguccu ggagcagguc      240

gggaacuccg acugccacua ccaggagggc cugaaggaca gcgaccucga gaacuccgag      300

gggcugagcc ggguguacuc caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu ccgccagaag gaguccaagc ugcaggagaa ccggaagauc      420

aucgaggccc agcgcaaggc gauccaggag cugcaguucg gcaacgagaa ggugagccuc      480

aagcuggagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccacccgg      540

caccucugca accugcugaa ggagacgugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gggaggagac ccgccaggug uacauggacc ucaacaacaa caucgagaag      660

augaucaccg cguucgagga gcugcggguc caggccgaga acagccgccu ggagaugcac      720

uucaagcuca aggaggacua cgagaagauc cagcaccugg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucucccug cuccugaucc agaucacgga gaaggagaac      840

aagaugaagg accugaccuu ccuccuggag gagagccggg acaaggugaa ccagcuggag      900

gagaagacca agcuccagag cgagaaccug aagcagucca ucgagaagca gcaccaccug      960

accaaggagc ucgaggacau caaggugagc cugcagcgcu ccgugagcac gcagaaggcc     1020

cuggaggagg accuccagau cgccaccaag accaucugcc agcugaccga ggagaaggag     1080

acgcagaugg aggaguccaa caaggcccgg gcggcccaca gcuucguggu caccgaguuc     1140

gagaccaccg ugugcucccu ggaggagcuc cugcgcacgg agcagcagcg gcuggagaag     1200

aacgaggacc agcucaagau ccugaccaug gagcugcaga agaaguccag cgagcucgag     1260

gagaugacca agcugaccaa caacaaggag guggagcugg aggagcucaa gaagguccug     1320

ggggagaagg agacgcugcu guacgagaac aagcaguucg agaagaucgc cgaggagcuc     1380

aagggcaccg agcaggagcu gaucgggcug cuccaggccc gcgagaagga ggugcacgac     1440

cuggagaucc agcugaccgc caucaccacg agcgagcagu acuacuccaa ggaggugaag     1500

gaccucaaga ccgagcugga gaacgagaag cugaagaaca ccgagcucac cagccacugc     1560

aacaagcugu cccuggagaa caaggagcuc acgcaggaga ccagcgacau gacccuggag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg gaugcucaag     1680

cagaucgaga accugcagga gaccgagacg cagcugcgca acgagcucga guacguccgg     1740

gaggagcuga agcagaagcg cgacgaggug aagugcaagc uggacaaguc cgaggagaac     1800

ugcaacaacc uccggaagca ggucgagaac aagaacaagu acaucgagga gcugcagcag     1860

gagaacaagg cgcugaagaa gaagggcacc gccgagagca agcagcucaa cguguacgag     1920

aucaagguga acaagcugga gcuggagcuc gaguccgcca agcagaaguu cggggagauc     1980

accgacaccu accagaagga gaucgaggac aagaagauca gcgaggagaa ccugcuggag     2040

gaggucgaga aggccaaggu gaucgccgac gaggcgguga agcuccagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuga uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacucc gagcugggcc ucuacaagag caaggagcag     2220

gagcagagcu cccugcgggc cagccuggag aucgagcucu ccaaccugaa ggccgagcug     2280

cucagcguga agaagcagcu ggagaucgag cgcgaggaga aggagaagcu gaagcgggag     2340

gcgaaggaga acaccgccac gcucaaggag aagaaggaca agaagaccca gaccuuccug     2400

cuggagaccc ccgagaucua cuggaagcuc gacuccaagg ccgugcccag ccagacgguc     2460

ucccgcaacu ucaccagcgu ggaccacggc aucuccaagg acaagcggga cuaccugugg     2520

accagcgcca agaacacccu guccacgccg cuccccaagg cguacaccgu gaagaccccc     2580

accaagccca agcugcagca gcgcgagaac cugaacaucc cgaucgagga gagcaagaag     2640

aagcggaaga uggccuucga guucgacauc aacuccgaca gcuccgagac gaccgaccuc     2700

cugagcaugg ucuccgagga ggagacccug aagacccucu accgcaacaa caacccgccc     2760

gccagccacc ugugcgugaa gacgcccaag aaggccccca gcucccugac cacccccggg     2820

agcacccuca aguucggcgc cauccggaag augcgcgagg accggugggc ggugaucgcc     2880

aagauggacc gcaagaagaa gcugaaggag gccgagaagc uguucgucug a              2931


<210>  3565
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYCP1__Homo_sapiens__AAI26267

<400>  3565
auggagaagc agaagcccuu cgcccucuuc gucccccccc gcuccuccuc cucccagguc       60

uccgccguca agccccagac ccucggcggc gacuccaccu ucuucaaguc cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accucuccaa gaacggcgag      180

aacaucgacu ccgaccccgc ccuccagaag gucaacuucc uccccguccu cgagcagguc      240

ggcaacuccg acugccacua ccaggagggc cucaaggacu ccgaccucga gaacuccgag      300

ggccucuccc gcgucuacuc caagcucuac aaggaggccg agaagaucaa gaaguggaag      360

gucuccaccg aggccgagcu ccgccagaag gaguccaagc uccaggagaa ccgcaagauc      420

aucgaggccc agcgcaaggc cauccaggag cuccaguucg gcaacgagaa ggucucccuc      480

aagcucgagg agggcaucca ggagaacaag gaccucauca aggagaacaa cgccacccgc      540

caccucugca accuccucaa ggagaccugc gcccgcuccg ccgagaagac caagaaguac      600

gaguacgagc gcgaggagac ccgccagguc uacauggacc ucaacaacaa caucgagaag      660

augaucaccg ccuucgagga gcuccgcguc caggccgaga acucccgccu cgagaugcac      720

uucaagcuca aggaggacua cgagaagauc cagcaccucg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggucucccuc cuccucaucc agaucaccga gaaggagaac      840

aagaugaagg accucaccuu ccuccucgag gagucccgcg acaaggucaa ccagcucgag      900

gagaagacca agcuccaguc cgagaaccuc aagcagucca ucgagaagca gcaccaccuc      960

accaaggagc ucgaggacau caaggucucc cuccagcgcu ccgucuccac ccagaaggcc     1020

cucgaggagg accuccagau cgccaccaag accaucugcc agcucaccga ggagaaggag     1080

acccagaugg aggaguccaa caaggcccgc gccgcccacu ccuucgucgu caccgaguuc     1140

gagaccaccg ucugcucccu cgaggagcuc cuccgcaccg agcagcagcg ccucgagaag     1200

aacgaggacc agcucaagau ccucaccaug gagcuccaga agaaguccuc cgagcucgag     1260

gagaugacca agcucaccaa caacaaggag gucgagcucg aggagcucaa gaagguccuc     1320

ggcgagaagg agacccuccu cuacgagaac aagcaguucg agaagaucgc cgaggagcuc     1380

aagggcaccg agcaggagcu caucggccuc cuccaggccc gcgagaagga gguccacgac     1440

cucgagaucc agcucaccgc caucaccacc uccgagcagu acuacuccaa ggaggucaag     1500

gaccucaaga ccgagcucga gaacgagaag cucaagaaca ccgagcucac cucccacugc     1560

aacaagcucu cccucgagaa caaggagcuc acccaggaga ccuccgacau gacccucgag     1620

cucaagaacc agcaggagga caucaacaac aacaagaagc aggaggagcg caugcucaag     1680

cagaucgaga accuccagga gaccgagacc cagcuccgca acgagcucga guacguccgc     1740

gaggagcuca agcagaagcg cgacgagguc aagugcaagc ucgacaaguc cgaggagaac     1800

ugcaacaacc uccgcaagca ggucgagaac aagaacaagu acaucgagga gcuccagcag     1860

gagaacaagg cccucaagaa gaagggcacc gccgagucca agcagcucaa cgucuacgag     1920

aucaagguca acaagcucga gcucgagcuc gaguccgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagaucu ccgaggagaa ccuccucgag     2040

gaggucgaga aggccaaggu caucgccgac gaggccguca agcuccagaa ggagaucgac     2100

aagcgcugcc agcacaagau cgccgagaug gucgcccuca uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gcgcgacucc gagcucggcc ucuacaaguc caaggagcag     2220

gagcaguccu cccuccgcgc cucccucgag aucgagcucu ccaaccucaa ggccgagcuc     2280

cucuccguca agaagcagcu cgagaucgag cgcgaggaga aggagaagcu caagcgcgag     2340

gccaaggaga acaccgccac ccucaaggag aagaaggaca agaagaccca gaccuuccuc     2400

cucgagaccc ccgagaucua cuggaagcuc gacuccaagg ccguccccuc ccagaccguc     2460

ucccgcaacu ucaccuccgu cgaccacggc aucuccaagg acaagcgcga cuaccucugg     2520

accuccgcca agaacacccu cuccaccccc cuccccaagg ccuacaccgu caagaccccc     2580

accaagccca agcuccagca gcgcgagaac cucaacaucc ccaucgagga guccaagaag     2640

aagcgcaaga uggccuucga guucgacauc aacuccgacu ccuccgagac caccgaccuc     2700

cucuccaugg ucuccgagga ggagacccuc aagacccucu accgcaacaa caaccccccc     2760

gccucccacc ucugcgucaa gacccccaag aaggcccccu ccucccucac cacccccggc     2820

uccacccuca aguucggcgc cauccgcaag augcgcgagg accgcugggc cgucaucgcc     2880

aagauggacc gcaagaagaa gcucaaggag gccgagaagc ucuucgucug a              2931


<210>  3566
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYCP1__Homo_sapiens__AAI26267

<400>  3566
auggagaagc agaaacccuu cgcccuguuu gugccuccaa gaagcuccuc uucacaaguc       60

agugcuguua agccgcagac ccucggcggg gacagcacau ucuuuaaauc cuucaacaag      120

ugcacugaag augacuuuga guuccccuuu gcaaaaacga aucuuucuaa gaacggagaa      180

aauaucgauu cggacccugc ccugcagaag gugaacuucu ugccaguauu agaacaggug      240

gguaauucag auugucacua ccaagaaggc cugaaagaca gcgaucuaga gaacagugag      300

gggcucucca gggucuauuc uaagcuguac aaagaagcgg agaagauuaa aaaguggaag      360

gugagcaccg aagcugagcu ucggcagaaa gaguccaagc ugcaggaaaa ucgcaaaaua      420

aucgaggccc agcgaaaggc aauucaagaa uugcaguuug gaaacgagaa aguuucacuc      480

aagcuggaag agggcaucca ggagaauaaa gaccugauua aggaaaacaa ugccacacgu      540

caucucugca acuuacugaa ggagacuugu gcuagaagug cagagaaaac caagaaauau      600

gaguacgaaa gggaggagac acgccaggug uauauggauc uuaauaacaa uaucgaaaag      660

augauaaccg ccuucgagga auugcggguc caagcugaga acagcagacu ggaaaugcac      720

uuuaaacuaa aggaggacua cgagaagauc cagcaucucg aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca agugucucug cuucugaucc agauuacuga gaaagaaaau      840

aagaugaagg acuugacauu ccuccuggag gaauccaggg auaaaguaaa ccaguuagag      900

gaaaagacca aacugcaguc agagaaucuc aagcaaagca ucgagaaaca gcaccaucuu      960

acgaaggaac uggaggacau aaagguuagu uugcagcggu cuguguccac ucagaaagcc     1020

cuagaagagg accugcaaau ugcgaccaag acaaucugcc agcucacuga agagaaagag     1080

acccagaugg aagagagcaa caaggcacgc gccgcucacu cguuugucgu gacagaguuc     1140

gaaaccacgg uguguucucu ggaggaacuu cugcgaacug agcagcaaag auuggagaaa     1200

aaugaagauc agcucaagau ucugacaaug gaauuacaga aaaaguccuc agagcuggag     1260

gaaaugacca agcuaacuaa caauaaagag gucgaacucg aggaacugaa gaaaguucuu     1320

ggugagaagg agacauugcu guacgaaaac aaacaguucg agaagaucgc cgaggaacuc     1380

aaggggaccg aacaagagcu gaucggacuu cugcaggcaa gggagaaaga agugcacgac     1440

uuggagauuc agcucacggc uauaaccaca agugaacaau acuauagcaa ggagguaaaa     1500

gaucugaaga cugaauuaga gaaugagaaa cugaagaaca ccgaacuaac aucccauugc     1560

aauaagcucu cucuggagaa caaagaacuu acucaggaga ccagcgacau gacauuggag     1620

cugaagaauc agcaggaaga uaucaacaau aacaaaaagc aagaggaacg gaugcucaaa     1680

cagauugaga accugcagga aaccgagacu caguuacgua augagcugga auacgugcgc     1740

gaggaacuua agcaaaagag agacgagguc aaauguaagu uggauaaauc agaagagaac     1800

ugcaauaacc ucaggaaaca gguggagaau aaaaacaagu auaucgagga acugcagcag     1860

gaaaauaaag cccuaaagaa gaaaggcacg gcggagagua agcaacugaa cguuuacgaa     1920

auaaaaguga auaagcucga gcuggagcuu gaauccgcca aacagaaguu uggcgagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagauca gcgaggaaaa cuugcuggag     2040

gaagucgaga aagcaaaggu gauugcugac gaagccguaa aauuacaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug guugcccuca uggaaaagca uaaacaccag     2160

uacgacaaga uaaucgagga acgagacucu gagcuggggc uuuauaaauc aaaggaacag     2220

gagcaaagua gccugcgcgc auccuuggag auugaacucu cuaaucugaa ggccgagcua     2280

cugucgguga aaaagcagcu cgaaaucgag agagaagaga aagagaagcu gaaaagggaa     2340

gcuaaggaga acacugcgac ccuuaaggag aaaaaggaua aaaagacaca gaccuucuug     2400

cuggaaacuc ccgagaucua cuggaaauua gacagcaagg cagucccuuc ccagacagug     2460

ucacggaauu uuacgagugu cgaucacgga auuucuaaag acaagcgcga uuaccucugg     2520

accagcgcca agaacacucu guccacacca cuucccaagg cuuauaccgu gaagacaccu     2580

acuaaaccaa agcugcaaca gagagaaaau cuaaacauac cgaucgagga aagcaaaaag     2640

aagaggaaaa uggccuucga guuugacauu aacucagauu cuuccgaaac cacggaccuc     2700

cugaguaugg uuagcgagga ggaaaccuug aagacacugu accguaauaa caaucccccu     2760

gcaucucauu uaugcgugaa aacuccaaag aaagcccccu ccucacucac cacaccuggu     2820

aguacucuga aguucggcgc uauccggaag augcgagagg auagaugggc cguaauugca     2880

aaaauggaca ggaagaagaa acuuaaagaa gcggagaagc uguuugucug a              2931


<210>  3567
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYCP1__Homo_sapiens__AAI26267

<400>  3567
auggagaagc agaagcccuu cgcccuguuc gugcccccca gaagcagcag cagccaggug       60

agcgccguga agccccagac ccugggcggc gacagcaccu ucuucaagag cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accugagcaa gaacggcgag      180

aacaucgaca gcgaccccgc ccugcagaag gugaacuucc ugcccgugcu ggagcaggug      240

ggcaacagcg acugccacua ccaggagggc cugaaggaca gcgaccugga gaacagcgag      300

ggccugagca gaguguacag caagcuguac aaggaggccg agaagaucaa gaaguggaag      360

gugagcaccg aggccgagcu gagacagaag gagagcaagc ugcaggagaa cagaaagauc      420

aucgaggccc agagaaaggc cauccaggag cugcaguucg gcaacgagaa ggugagccug      480

aagcuggagg agggcaucca ggagaacaag gaccugauca aggagaacaa cgccaccaga      540

caccugugca accugcugaa ggagaccugc gccagaagcg ccgagaagac caagaaguac      600

gaguacgaga gagaggagac cagacaggug uacauggacc ugaacaacaa caucgagaag      660

augaucaccg ccuucgagga gcugagagug caggccgaga acagcagacu ggagaugcac      720

uucaagcuga aggaggacua cgagaagauc cagcaccugg agcaggagua caagaaggag      780

aucaacgaca aggagaagca ggugagccug cugcugaucc agaucaccga gaaggagaac      840

aagaugaagg accugaccuu ccugcuggag gagagcagag acaaggugaa ccagcuggag      900

gagaagacca agcugcagag cgagaaccug aagcagagca ucgagaagca gcaccaccug      960

accaaggagc uggaggacau caaggugagc cugcagagaa gcgugagcac ccagaaggcc     1020

cuggaggagg accugcagau cgccaccaag accaucugcc agcugaccga ggagaaggag     1080

acccagaugg aggagagcaa caaggccaga gccgcccaca gcuucguggu gaccgaguuc     1140

gagaccaccg ugugcagccu ggaggagcug cugagaaccg agcagcagag acuggagaag     1200

aacgaggacc agcugaagau ccugaccaug gagcugcaga agaagagcag cgagcuggag     1260

gagaugacca agcugaccaa caacaaggag guggagcugg aggagcugaa gaaggugcug     1320

ggcgagaagg agacccugcu guacgagaac aagcaguucg agaagaucgc cgaggagcug     1380

aagggcaccg agcaggagcu gaucggccug cugcaggcca gagagaagga ggugcacgac     1440

cuggagaucc agcugaccgc caucaccacc agcgagcagu acuacagcaa ggaggugaag     1500

gaccugaaga ccgagcugga gaacgagaag cugaagaaca ccgagcugac cagccacugc     1560

aacaagcuga gccuggagaa caaggagcug acccaggaga ccagcgacau gacccuggag     1620

cugaagaacc agcaggagga caucaacaac aacaagaagc aggaggagag aaugcugaag     1680

cagaucgaga accugcagga gaccgagacc cagcugagaa acgagcugga guacgugaga     1740

gaggagcuga agcagaagag agacgaggug aagugcaagc uggacaagag cgaggagaac     1800

ugcaacaacc ugagaaagca gguggagaac aagaacaagu acaucgagga gcugcagcag     1860

gagaacaagg cccugaagaa gaagggcacc gccgagagca agcagcugaa cguguacgag     1920

aucaagguga acaagcugga gcuggagcug gagagcgcca agcagaaguu cggcgagauc     1980

accgacaccu accagaagga gaucgaggac aagaagauca gcgaggagaa ccugcuggag     2040

gagguggaga aggccaaggu gaucgccgac gaggccguga agcugcagaa ggagaucgac     2100

aagagaugcc agcacaagau cgccgagaug guggcccuga uggagaagca caagcaccag     2160

uacgacaaga ucaucgagga gagagacagc gagcugggcc uguacaagag caaggagcag     2220

gagcagagca gccugagagc cagccuggag aucgagcuga gcaaccugaa ggccgagcug     2280

cugagcguga agaagcagcu ggagaucgag agagaggaga aggagaagcu gaagagagag     2340

gccaaggaga acaccgccac ccugaaggag aagaaggaca agaagaccca gaccuuccug     2400

cuggagaccc ccgagaucua cuggaagcug gacagcaagg ccgugcccag ccagaccgug     2460

agcagaaacu ucaccagcgu ggaccacggc aucagcaagg acaagagaga cuaccugugg     2520

accagcgcca agaacacccu gagcaccccc cugcccaagg ccuacaccgu gaagaccccc     2580

accaagccca agcugcagca gagagagaac cugaacaucc ccaucgagga gagcaagaag     2640

aagagaaaga uggccuucga guucgacauc aacagcgaca gcagcgagac caccgaccug     2700

cugagcaugg ugagcgagga ggagacccug aagacccugu acagaaacaa caaccccccc     2760

gccagccacc ugugcgugaa gacccccaag aaggccccca gcagccugac cacccccggc     2820

agcacccuga aguucggcgc caucagaaag augagagagg acagaugggc cgugaucgcc     2880

aagauggaca gaaagaagaa gcugaaggag gccgagaagc uguucgugug a              2931


<210>  3568
<211>  2931
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYCP1__Homo_sapiens__AAI26267

<400>  3568
auggagaagc agaaacccuu cgcccuguuu gugccuccga gaagcuccuc uagccaaguc       60

uccgcuguua agccccagac ccucggcggg gacucuacau ucuuuaagag cuucaacaag      120

ugcacggaag augacuuuga guucccuuuu gccaaaacca aucuguccaa gaacggagaa      180

aauaucgauu cugaccccgc gcuucagaag gugaacuucc ugccugugcu cgagcagguc      240

ggcaauagcg auugucacua ccaagaaggg cugaaagacu ccgaucuuga gaacagcgag      300

ggacugucuc ggguguauuc caagcucuac aaagaagcug agaagauuaa aaaguggaag      360

guuagcacag aagccgagcu gcgccagaaa gagucuaagc ugcaggaaaa uagaaaaauc      420

auugaggccc agcggaaggc uauccaagaa cuccaguuug gcaacgagaa agugucccug      480

aaacuugaag aggggauuca ggagaauaaa gaccugauca aggaaaacaa ugccacccgc      540

caucucugca accugcuuaa ggagacaugu gcuagaagcg ccgaaaagac caagaaauau      600

gaguacgaac gggaggagac acgccagguc uauauggauc ugaauaacaa uaucgaaaag      660

augauuaccg cguucgagga acucagagug caagccgaga acucucggcu ggaaaugcac      720

uuuaaacuga aggaggacua cgagaagauc cagcaucucg aacaggagua uaaaaaggaa      780

auuaacgaua aagagaagca aguuucccug cuucugaucc agauuacgga gaaagaaaau      840

aagaugaagg accucaccuu ccugcuugag gaaagccgcg auaaagugaa ccagcuggag      900

gaaaagacaa aacuccaguc cgagaaucug aagcaaucua ucgagaaaca gcaccaucug      960

accaaggaac ucgaggacau uaaggucagc cugcagagau ccgugagcac acagaaagcu     1020

cuugaagagg accugcaaau cgccaccaag acgaucugcc agcucacaga agagaaagag     1080

acccagaugg aagagucuaa caaggcucgg gccgcgcacu ccuuuguggu cacagaguuc     1140

gaaaccaccg uuuguagccu ggaggaacuu cugcgcacag agcagcaaag acucgaaaag     1200

aaugaggauc agcugaagau ucugacgaug gaacuccaga aaaagucuag cgagcuggag     1260

gaaaugacca aacuuacaaa caauaaagag guggaacugg aggaacucaa gaaagugcug     1320

ggagagaagg agacccugcu uuacgaaaac aaacaguucg agaagaucgc cgaggaacuc     1380

aagggcacag aacaagagcu gauuggccug cuccaggcuc gggagaaaga aguccacgac     1440

cuggagaucc agcuuaccgc cauuacgaca uccgaacaau acuauucuaa ggaggugaaa     1500

gaucugaaga ccgaacucga gaaugagaaa cugaagaaca ccgaacugac aagccauugc     1560

aauaaacuuu cccucgagaa caaagaacug acccaggaga caagcgacau gacgcuggag     1620

cucaagaauc agcaggaaga uaucaacaau aacaaaaagc aagaggaacg caugcugaaa     1680

cagaucgaga accuucagga aaccgagaca cagcugagaa augagcucga auacguucgg     1740

gaggaacuga agcaaaagag agacgaggug aaauguaagc uggauaaauc ugaagagaac     1800

ugcaauaacc uucgcaagca ggucgagaau aaaaacaagu auauugagga acuccagcag     1860

gaaaauaaag cucugaagaa gaaagggacc gccgagucca agcaacugaa cguguacgaa     1920

aucaaaguua auaagcucga gcuggagcuu gaaagcgcca aacagaaguu uggagagauu     1980

acagacaccu aucagaagga aaucgaggau aaaaagauuu cugaggaaaa ccugcucgag     2040

gaaguggaga aagcuaaggu caucgcggac gaagccguga aacugcaaaa ggagaucgau     2100

aagcgguguc agcacaaaau ugcugagaug gucgcccuga uggaaaagca uaaacaccag     2160

uacgacaaga ucauugagga aagagacucc gagcuuggcc ucuauaaaag caaggaacag     2220

gagcaauccu cucugcgcgc cagccuggag aucgaacucu ccaaucugaa ggcugagcuu     2280

cugucuguga aaaagcagcu cgaaauugag cgggaagaga aagagaagcu gaaaagagaa     2340

gccaaggaga acacggcgac ccugaaggaa aagaaggaua aaaagacaca gaccuuccuu     2400

cuggagacac ccgagaucua cuggaaacuc gacagcaagg cuguuccuuc ccagaccgug     2460

agccgcaauu uuacgucugu cgaucacggg auuuccaaag acaagcggga uuaccugugg     2520

acaagcgcca agaacacccu cucuacaccg cugcccaaag ccuauaccgu gaagaccccu     2580

acaaaaccca aacuucaaca gagagaaaau cugaacaucc cuaucgagga auccaaaaag     2640

aagcgcaaaa uggcuuucga guuugacauu aacagcgauu cuagcgaaac gaccgaccuc     2700

cuguccaugg uuagcgagga ggaaacacug aagacccuuu accggaauaa caaucccccg     2760

gccucucauc ugugcgugaa aacaccuaag aaagcucccu ccagccucac cacgccugga     2820

uccacacuga aguucggcgc caucagaaag augcgcgagg aucggugggc ggucauugcc     2880

aaaauggaca gaaagaaaaa gcucaaagaa gcugagaagc uguuugugug a              2931


<210>  3569
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__Q3MHC4

<400>  3569

Met Glu Lys Gln Lys Pro Phe Ala Leu Phe Val Pro Pro Arg Ser Ser 
1               5                   10                  15      


Ser Ser Gln Val Ser Ala Val Lys Pro Gln Thr Leu Gly Gly Asp Ser 
            20                  25                  30          


Thr Phe Phe Lys Ser Phe Asn Lys Cys Thr Glu Asp Asp Phe Glu Phe 
        35                  40                  45              


Pro Phe Ala Lys Thr Asn Leu Ser Lys Asn Gly Glu Asn Ile Asp Ser 
    50                  55                  60                  


Asp Pro Ala Leu Gln Asn Val Asn Phe Leu Pro Val Leu Glu Gln Val 
65                  70                  75                  80  


Gly Asn Ser Asp Cys His Tyr Gln Glu Gly Leu Lys Asp Ser Asp Leu 
                85                  90                  95      


Glu Asn Ser Glu Gly Leu Ser Arg Val Tyr Ser Lys Leu 
            100                 105                 


<210>  3570
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYCP1__Homo_sapiens__AAI05300

<400>  3570
auggaaaagc aaaagcccuu ugcauuguuc guaccaccga gaucaagcag cagucaggug       60

ucugcgguga aaccucagac ccugggaggc gauuccacuu ucuucaagag uuucaacaaa      120

uguacugaag augauuuuga guuuccauuu gcaaagacua aucucuccaa aaauggggaa      180

aacauugauu cagauccugc uuuacaaaac guuaauuucu ugcccgugcu ugagcagguu      240

gguaauucug acugucacua ucaggaagga cuaaaagacu cugauuugga gaauucagag      300

ggauugagca gaguguauuc aaaacuguaa                                       330


<210>  3571
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYCP1__Homo_sapiens__AAI05300

<400>  3571
auggagaagc agaagcccuu cgcccuguuc gugccgcccc gcagcuccag cucccaggug       60

agcgccguga agccccagac ccucggcggg gacuccaccu ucuucaagag cuucaacaag      120

ugcacggagg acgacuucga guuccccuuc gcgaagacca accuguccaa gaacggcgag      180

aacaucgaca gcgacccggc ccugcagaac gugaacuucc uccccguccu ggagcagguc      240

gggaacuccg acugccacua ccaggagggc cugaaggaca gcgaccucga gaacuccgag      300

gggcugagcc ggguguacuc caagcuguga                                       330


<210>  3572
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYCP1__Homo_sapiens__AAI05300

<400>  3572
auggagaagc agaagcccuu cgcccucuuc gucccccccc gcuccuccuc cucccagguc       60

uccgccguca agccccagac ccucggcggc gacuccaccu ucuucaaguc cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accucuccaa gaacggcgag      180

aacaucgacu ccgaccccgc ccuccagaac gucaacuucc uccccguccu cgagcagguc      240

ggcaacuccg acugccacua ccaggagggc cucaaggacu ccgaccucga gaacuccgag      300

ggccucuccc gcgucuacuc caagcucuga                                       330


<210>  3573
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYCP1__Homo_sapiens__AAI05300

<400>  3573
auggagaagc agaaacccuu cgcccuguuu gugccuccaa gaagcuccuc uucacaaguc       60

agugcuguua agccgcagac ccucggcggg gacagcacau ucuuuaaauc cuucaacaag      120

ugcacugaag augacuuuga guuccccuuu gcaaaaacga aucuuucuaa gaacggagaa      180

aauaucgauu cggacccugc ccugcagaac gugaauuucu ugccaguauu agaacaggug      240

gguaacucag auugucacua ccaagagggc cugaaggaca gcgaucuaga gaauagugag      300

gggcucucca gggucuauuc uaaacuguga                                       330


<210>  3574
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYCP1__Homo_sapiens__AAI05300

<400>  3574
auggagaagc agaagcccuu cgcccuguuc gugcccccca gaagcagcag cagccaggug       60

agcgccguga agccccagac ccugggcggc gacagcaccu ucuucaagag cuucaacaag      120

ugcaccgagg acgacuucga guuccccuuc gccaagacca accugagcaa gaacggcgag      180

aacaucgaca gcgaccccgc ccugcagaac gugaacuucc ugcccgugcu ggagcaggug      240

ggcaacagcg acugccacua ccaggagggc cugaaggaca gcgaccugga gaacagcgag      300

ggccugagca gaguguacag caagcuguga                                       330


<210>  3575
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYCP1__Homo_sapiens__AAI05300

<400>  3575
auggagaagc agaaacccuu cgcccuguuu gugccuccga gaagcuccuc uagccaaguc       60

uccgcuguua agccccagac ccucggcggg gacucuacau ucuuuaagag cuucaacaaa      120

ugcacggaag augacuuuga guucccuuuu gccaaaacca aucuguccaa gaacggagaa      180

aauaucgauu cugaccccgc gcuucagaac gugaauuucc ugccugugcu cgagcagguc      240

ggcaacagcg auugucacua ccaagaaggg cugaaggacu ccgaucuuga gaauagcgag      300

ggacugucuc ggguguauuc caaacucuga                                       330


<210>  3576
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-1__Homo_sapiens__A4PIV7

<400>  3576

Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr Gly Tyr Gln Gln Pro Ser 
    290                 295                 300                 


Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr Glu Asp Ser Ser Gln His 
305                 310                 315                 320 


Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala Tyr 
                325                 330                 335     


Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln Tyr 
            340                 345                 350         


Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro Ser 
        355                 360                 365             


Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln Gly 
    370                 375                 380                 


Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met Pro Lys Lys Pro 
                405                 410                 415     


Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu Ala Ser Gly Pro 
            420                 425                 430         


Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys Ala Asn Ile Ser 
        435                 440                 445             


Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly Lys His Ala Trp 
    450                 455                 460                 


Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile 
465                 470                 475                 480 


Ser Asp Pro Glu Glu Asp Asp Glu 
                485             


<210>  3577
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3577
augucugugg cuuucgcggc cccgaggcag cgaggcaagg gggagaucac ucccgcugcg       60

auucagaaga uguuggauga caauaaccau cuuauucagu guauaaugga cucucagaau      120

aaaggaaaga ccucagagug uucucaguau cagcagaugu ugcacacaaa cuugguauac      180

cuugcuacaa uagcagauuc uaaucaaaau augcagucuc uuuuaccagc accacccaca      240

cagaauaugc cuaugggucc uggagggaug aaucagagcg gcccuccccc accuccacgc      300

ucucacaaca ugccuucaga uggaauggua gguggggguc cuccugcacc gcacaugcag      360

aaccagauga acggccagau gccugggccu aaccauaugc cuaugcaggg accuggaccc      420

aaucaacuca auaugacaaa caguuccaug aauaugccuu caaguagcca uggauccaug      480

ggagguuaca accauucugu gccaucaucg cagagcaugc caguacagaa ucagaugaca      540

augagucagg gacaaccaau gggaaacuau ggucccagac caaauaugag uaugcagcca      600

aaccaagguc caaugaugca ucagcagccu ccuucucagc aauacaauau gccacaggga      660

ggcggacagc auuaccaagg acagcagcca ccuaugggga ugauggguca aguuaaccaa      720

ggcaaucaua ugauggguca gagacagauu ccucccuaua gaccuccuca acagggccca      780

ccacagcagu acucaggcca ggaagacuau uacggggacc aauacaguca ugguggacaa      840

gguccuccag aaggcaugaa ccagcaauau uacccugaug gucauaauga uuacgguuau      900

cagcaaccgu cguauccuga acaaggcuac gauaggccuu augaggauuc cucacaacau      960

uacuacgaag gaggaaauuc acaguauggc caacagcaag augcauacca gggaccaccu     1020

ccacaacagg gauauccacc ccagcagcag caguacccag ggcagcaagg uuacccagga     1080

cagcagcagg gcuacggucc uucacagggu gguccagguc cucaguaucc uaacuaccca     1140

cagggacaag gucagcagua uggaggauau agaccaacac agccuggacc accacagcca     1200

ccccagcaga ggccuuaugg auaugaccag aucaugccca agaagccagc agaggacgaa     1260

aaugauucga agggaguguc agaagcaucu ggcccacaaa acgaugggaa acaacugcac     1320

cccccaggaa aagcaaauau uucugagaag auuaauaaga gaucuggacc caaaaggggg     1380

aaacaugccu ggacccacag acugcgugag agaaagcagc uggugauuua ugaagagauc     1440

agcgacccug aggaagauga cgaguaa                                         1467


<210>  3578
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3578
augagcgugg ccuucgccgc gccccgccag cggggcaagg gggagaucac cccggccgcc       60

auccagaaga ugcuggacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccagcgagug cucccaguac cagcagaugc ugcacacgaa ccuggucuac      180

cucgccacca ucgccgacag caaccagaac augcaguccc ugcugcccgc gccccccacc      240

cagaacaugc cgauggggcc cggcgggaug aaccagagcg gccccccccc gcccccccgc      300

ucccacaaca ugcccagcga cggcauggug gggggcgggc cgcccgcccc ccacaugcag      360

aaccagauga acggccagau gcccgggccg aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccagcaug aacaugccgu ccagcuccca cgggagcaug      480

ggcggguaca accacuccgu gcccagcucc cagagcaugc ccguccagaa ccagaugacg      540

augucccagg gccagcccau gggcaacuac gggccgcggc ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccg cccagccagc aguacaacau gccccagggg      660

ggcgggcagc acuaccaggg ccagcagccg cccaugggca ugauggggca ggugaaccag      720

ggcaaccaca ugauggggca gcgccagauc ccccccuacc ggccgcccca gcagggcccc      780

ccccagcagu acuccgggca ggaggacuac uacggcgacc aguacagcca cggcgggcag      840

ggcccgcccg aggggaugaa ccagcaguac uaccccgacg gccacaacga cuacggguac      900

cagcagcccu ccuacccgga gcagggcuac gaccgccccu acgaggacag cucccagcac      960

uacuacgagg gcgggaacag ccaguacggc cagcagcagg acgccuacca ggggcccccc     1020

ccgcagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg guacccgggc     1080

cagcagcagg gguacggccc cucccagggg ggccccggcc cccaguaccc gaacuacccc     1140

caggggcagg gccagcagua cgggggcuac cggcccaccc agccggggcc cccccagccc     1200

ccgcagcagc gccccuacgg cuacgaccag aucaugccca agaagcccgc cgaggacgag     1260

aacgacagca agggcguguc cgaggcgagc gggccgcaga acgacggcaa gcagcugcac     1320

ccccccggga aggccaacau cuccgagaag aucaacaagc ggagcggccc caagcgcggg     1380

aagcacgccu ggacccaccg gcugcgcgag cggaagcagc ucgucaucua cgaggagauc     1440

uccgacccgg aggaggacga cgaguga                                         1467


<210>  3579
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3579
auguccgucg ccuucgccgc cccccgccag cgcggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcucgacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccuccgagug cucccaguac cagcagaugc uccacaccaa ccucgucuac      180

cucgccacca ucgccgacuc caaccagaac augcaguccc uccuccccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccaguccg gccccccccc ccccccccgc      300

ucccacaaca ugcccuccga cggcaugguc ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccuccaug aacaugcccu ccuccuccca cggcuccaug      480

ggcggcuaca accacuccgu ccccuccucc caguccaugc ccguccagaa ccagaugacc      540

augucccagg gccagcccau gggcaacuac ggcccccgcc ccaacauguc caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccucccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggucaaccag      720

ggcaaccaca ugaugggcca gcgccagauc ccccccuacc gcccccccca gcagggcccc      780

ccccagcagu acuccggcca ggaggacuac uacggcgacc aguacuccca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gccacaacga cuacggcuac      900

cagcagcccu ccuaccccga gcagggcuac gaccgccccu acgaggacuc cucccagcac      960

uacuacgagg gcggcaacuc ccaguacggc cagcagcagg acgccuacca gggccccccc     1020

ccccagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg cuaccccggc     1080

cagcagcagg gcuacggccc cucccagggc ggccccggcc cccaguaccc caacuacccc     1140

cagggccagg gccagcagua cggcggcuac cgccccaccc agcccggccc cccccagccc     1200

ccccagcagc gccccuacgg cuacgaccag aucaugccca agaagcccgc cgaggacgag     1260

aacgacucca agggcgucuc cgaggccucc ggcccccaga acgacggcaa gcagcuccac     1320

ccccccggca aggccaacau cuccgagaag aucaacaagc gcuccggccc caagcgcggc     1380

aagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucaucua cgaggagauc     1440

uccgaccccg aggaggacga cgaguga                                         1467


<210>  3580
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3580
augagcgugg ccuucgcugc acccagacag aggggcaagg gggagaucac cccugccgcg       60

auucagaaaa ugcuggacga uaacaaucac cucauacaau gcaucaugga cucccagaac      120

aagggaaaaa caucugaaug uucacaguac caacagaugc uucauacuaa ucuggucuau      180

uuggcuacga uugccgauag uaaccagaau augcagagcu uacugccagc accgcccacc      240

caaaacaugc cuaugggucc aggcgggaug aaucaguccg gacccccucc acccccucgg      300

ucucacaaca ugccaucgga cggcaugguu ggugggggac cgcccgcccc ucauaugcag      360

aaucagauga acggccaaau gccaggcccc aaucacaugc cuaugcaggg gccaggaccc      420

aaccagcuaa auaugacaaa cucaagcaug aauaugccga guuccucuca ugguagcaug      480

ggcggguaca accacuccgu gccuucaagu caaagcaugc ccguacagaa ccagaugacu      540

augucucagg gacaaccaau gggcaauuau gguccucgcc ccaacauguc caugcagcca      600

aaucaggggc ccaugaugca ccagcaaccu ccaucacagc aguacaacau gccgcaggga      660

ggcggccaac auuaucaggg gcagcagccc ccuaugggaa ugauggguca agugaaucag      720

ggcaaccaca ugauggggca gcgacaaauc ccacccuacc guccuccaca gcagggaccc      780

ccgcagcaau auagcggcca ggaggauuac uacggugacc aguauaguca ugggggccag      840

ggaccuccag aaggcaugaa ucaacaguac uaucccgaug ggcacaacga cuacggauau      900

cagcagccuu cuuaccccga gcaagguuau gauagaccau acgaagacuc cagccagcac      960

uacuaugagg gcggaaauuc gcaguacggg caacagcagg augcuuauca gggcccuccc     1020

ccacaacagg guuacccgcc ucagcagcaa caguaucccg ggcagcaggg cuacccagga     1080

caacagcagg gcuaugggcc cucucaggga gguccuggcc cacaauaccc caacuacccu     1140

caggggcagg gacaacagua uggcgguuac aggccgaccc agccagggcc cccucagcca     1200

ccccaacagc ggccuuaugg cuacgaccag auuaugccga agaaacccgc agaggaugaa     1260

aaugacucca agggagucuc agaggccagu ggcccacaga acgacgggaa gcaacuccau     1320

ccucccggaa aagcuaauau cagcgaaaag auaaacaaac gcuccggccc aaagagaggu     1380

aaacacgccu ggacacauag gcugcgggag cgcaagcagc uugugaucua ugaggaaauu     1440

ucugauccug aggaagacga ugaguga                                         1467


<210>  3581
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3581
augagcgugg ccuucgccgc ccccagacag agaggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcuggacga caacaaccac cugauccagu gcaucaugga cagccagaac      120

aagggcaaga ccagcgagug cagccaguac cagcagaugc ugcacaccaa ccugguguac      180

cuggccacca ucgccgacag caaccagaac augcagagcc ugcugcccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccagagcg gccccccccc cccccccaga      300

agccacaaca ugcccagcga cggcauggug ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuga acaugaccaa cagcagcaug aacaugccca gcagcagcca cggcagcaug      480

ggcggcuaca accacagcgu gcccagcagc cagagcaugc ccgugcagaa ccagaugacc      540

augagccagg gccagcccau gggcaacuac ggccccagac ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccagccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggugaaccag      720

ggcaaccaca ugaugggcca gagacagauc ccccccuaca gaccccccca gcagggcccc      780

ccccagcagu acagcggcca ggaggacuac uacggcgacc aguacagcca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gccacaacga cuacggcuac      900

cagcagccca gcuaccccga gcagggcuac gacagacccu acgaggacag cagccagcac      960

uacuacgagg gcggcaacag ccaguacggc cagcagcagg acgccuacca gggccccccc     1020

ccccagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg cuaccccggc     1080

cagcagcagg gcuacggccc cagccagggc ggccccggcc cccaguaccc caacuacccc     1140

cagggccagg gccagcagua cggcggcuac agacccaccc agcccggccc cccccagccc     1200

ccccagcaga gacccuacgg cuacgaccag aucaugccca agaagcccgc cgaggacgag     1260

aacgacagca agggcgugag cgaggccagc ggcccccaga acgacggcaa gcagcugcac     1320

ccccccggca aggccaacau cagcgagaag aucaacaaga gaagcggccc caagagaggc     1380

aagcacgccu ggacccacag acugagagag agaaagcagc uggugaucua cgaggagauc     1440

agcgaccccg aggaggacga cgaguga                                         1467


<210>  3582
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYT-SSX-1__Homo_sapiens__BAF56181

<400>  3582
augagcgugg ccuucgcugc ccccagacag cggggcaagg gggagaucac cccugcggcu       60

auucagaaaa ugcuggacga uaacaaucac cucauccaau gcauuaugga cucccagaac      120

aagggaaaaa caucugaaug uagccaguac caacagaugc ugcauacgaa ucuugucuau      180

cuggccacca ucgccgauuc caaccagaau augcagucuc uccugccggc ucccccuaca      240

caaaacaugc ccaugggccc ugggggaaug aaucagagcg ggcccccucc gcccccucgc      300

ucccacaaca ugcccucuga cgggaugguu ggaggcggcc cucccgcccc gcauaugcag      360

aaucagauga acgggcaaau gccuggaccc aaucacaugc cuaugcaggg ccccgggccc      420

aaccagcuua auaugaccaa cagcuccaug aauaugccuu cuagcuccca uggaagcaug      480

ggcggguaca accacucugu gccguccagc caaucuaugc ccgugcagaa ccagaugaca      540

augucccagg gacaaccuau gggcaauuau ggccccagac cuaacaugag caugcagccc      600

aaucaggggc cgaugaugca ccagcaaccu cccucccagc aguacaacau gccucaggga      660

ggcgggcaac auuaucaggg acagcagccc ccuaugggca ugauggggca agucaaucag      720

ggaaaccaca ugaugggcca gcggcaaauu cccccguacc gcccucccca gcaggggccc      780

ccucagcaau auucuggcca ggaggauuac uacggagacc aguauagcca uggcgggcag      840

ggaccgcccg aaggcaugaa ucaacaguac uauccugaug ggcacaacga cuacggcuau      900

cagcagcccu ccuacccuga gcaaggauau gauagacccu acgaagacag cucucagcac      960

uacuaugagg gcggcaauuc ccaguacgga caacagcagg augcuuauca gggcccuccc     1020

ccgcaacagg gguacccucc ccagcagcaa caguauccug gacagcaggg cuaccccggg     1080

caacagcagg gcuauggacc gagccagggc gggccuggac cccaauaccc uaacuacccc     1140

cagggccagg ggcaacagua uggaggcuac cggcccaccc agccugggcc gccccagccu     1200

ccccaacagc gcccuuaugg cuacgaccag aucaugccca agaaaccugc cgaggaugaa     1260

aaugacucua agggagugag cgaggcgucc ggcccgcaga acgacgggaa gcaacugcau     1320

cccccuggaa aagccaauau cucugaaaag auuaacaaaa gaagcggccc caagcggggg     1380

aaacacgcuu ggacacaucg ccucagagag cggaagcagc ugguuaucua ugaggaaauu     1440

uccgauccug aggaagacga ugaguga                                         1467


<210>  3583
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-1__Homo_sapiens__A4PIV8

<400>  3583

Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala 
    290                 295                 300                 


Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln 
305                 310                 315                 320 


Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro 
                325                 330                 335     


Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln 
            340                 345                 350         


Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln 
        355                 360                 365             


Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met Pro Lys Lys 
    370                 375                 380                 


Pro Ala Glu Asp Glu Asn Asp Ser Lys Gly Val Ser Glu Ala Ser Gly 
385                 390                 395                 400 


Pro Gln Asn Asp Gly Lys Gln Leu His Pro Pro Gly Lys Ala Asn Ile 
                405                 410                 415     


Ser Glu Lys Ile Asn Lys Arg Ser Gly Pro Lys Arg Gly Lys His Ala 
            420                 425                 430         


Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu 
        435                 440                 445             


Ile Ser Asp Pro Glu Glu Asp Asp Glu 
    450                 455         


<210>  3584
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3584
augucugugg cuuucgcggc cccgaggcag cgaggcaagg gggagaucac ucccgcugcg       60

auucagaaga uguuggauga caauaaccau cuuauucagu guauaaugga cucucagaau      120

aaaggaaaga ccucagagug uucucaguau cagcagaugu ugcacacaaa cuugguauac      180

cuugcuacaa uagcagauuc uaaucaaaau augcagucuc uuuuaccagc accacccaca      240

cagaauaugc cuaugggucc uggagggaug aaucagagcg gcccuccccc accuccacgc      300

ucucacaaca ugccuucaga uggaauggua gguggggguc cuccugcacc gcacaugcag      360

aaccagauga acggccagau gccugggccu aaccauaugc cuaugcaggg accuggaccc      420

aaucaacuca auaugacaaa caguuccaug aauaugccuu caaguagcca uggauccaug      480

ggagguuaca accauucugu gccaucaucg cagagcaugc caguacagaa ucagaugaca      540

augagucagg gacaaccaau gggaaacuau ggucccagac caaauaugag uaugcagcca      600

aaccaagguc caaugaugca ucagcagccu ccuucucagc aauacaauau gccacaggga      660

ggcggacagc auuaccaagg acagcagcca ccuaugggga ugauggguca aguuaaccaa      720

ggcaaucaua ugauggguca gagacagauu ccucccuaua gaccuccuca acagggccca      780

ccacagcagu acucaggcca ggaagacuau uacggggacc aauacaguca ugguggacaa      840

gguccuccag aaggcaugaa ccagcaauau uacccugaug gaaauucaca guauggccaa      900

cagcaagaug cauaccaggg accaccucca caacagggau auccacccca gcagcagcag      960

uacccagggc agcaagguua cccaggacag cagcagggcu acgguccuuc acaggguggu     1020

ccagguccuc aguauccuaa cuacccacag ggacaagguc agcaguaugg aggauauaga     1080

ccaacacagc cuggaccacc acagccaccc cagcagaggc cuuauggaua ugaccagauc     1140

augcccaaga agccagcaga ggacgaaaau gauucgaagg gagugucaga agcaucuggc     1200

ccacaaaacg augggaaaca acugcacccc ccaggaaaag caaauauuuc ugagaagauu     1260

aauaagagau cuggacccaa aagggggaaa caugccugga cccacagacu gcgugagaga     1320

aagcagcugg ugauuuauga agagaucagc gacccugagg aagaugacga guaa           1374


<210>  3585
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3585
augagcgugg ccuucgccgc gccccgccag cggggcaagg gggagaucac cccggccgcc       60

auccagaaga ugcuggacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccagcgagug cucccaguac cagcagaugc ugcacacgaa ccuggucuac      180

cucgccacca ucgccgacag caaccagaac augcaguccc ugcugcccgc gccccccacc      240

cagaacaugc cgauggggcc cggcgggaug aaccagagcg gccccccccc gcccccccgc      300

ucccacaaca ugcccagcga cggcauggug gggggcgggc cgcccgcccc ccacaugcag      360

aaccagauga acggccagau gcccgggccg aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccagcaug aacaugccgu ccagcuccca cgggagcaug      480

ggcggguaca accacuccgu gcccagcucc cagagcaugc ccguccagaa ccagaugacg      540

augucccagg gccagcccau gggcaacuac gggccgcggc ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccg cccagccagc aguacaacau gccccagggg      660

ggcgggcagc acuaccaggg ccagcagccg cccaugggca ugauggggca ggugaaccag      720

ggcaaccaca ugauggggca gcgccagauc ccccccuacc ggccgcccca gcagggcccc      780

ccccagcagu acuccgggca ggaggacuac uacggcgacc aguacagcca cggcgggcag      840

ggcccgcccg aggggaugaa ccagcaguac uaccccgacg gcaacuccca guacgggcag      900

cagcaggacg ccuaccaggg ccccccgccc cagcagggcu acccccccca gcagcagcag      960

uacccggggc agcagggcua ccccgggcag cagcagggcu acggccccag ccaggggggc     1020

cccgggccgc aguaccccaa cuacccccag ggccaggggc agcaguacgg cggcuaccgc     1080

cccacccagc cggggccccc ccagccgccc cagcagcggc ccuacggcua cgaccagauc     1140

augcccaaga agccggccga ggacgagaac gacuccaagg gggugagcga ggcguccggc     1200

ccccagaacg acgggaagca gcugcacccc cccggcaagg ccaacaucag cgagaagauc     1260

aacaagcgcu ccggcccgaa gcgggggaag cacgccugga cccaccgccu gcgggagcgc     1320

aagcagcucg ucaucuacga ggagaucagc gaccccgagg aggacgacga guga           1374


<210>  3586
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3586
auguccgucg ccuucgccgc cccccgccag cgcggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcucgacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccuccgagug cucccaguac cagcagaugc uccacaccaa ccucgucuac      180

cucgccacca ucgccgacuc caaccagaac augcaguccc uccuccccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccaguccg gccccccccc ccccccccgc      300

ucccacaaca ugcccuccga cggcaugguc ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccuccaug aacaugcccu ccuccuccca cggcuccaug      480

ggcggcuaca accacuccgu ccccuccucc caguccaugc ccguccagaa ccagaugacc      540

augucccagg gccagcccau gggcaacuac ggcccccgcc ccaacauguc caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccucccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggucaaccag      720

ggcaaccaca ugaugggcca gcgccagauc ccccccuacc gcccccccca gcagggcccc      780

ccccagcagu acuccggcca ggaggacuac uacggcgacc aguacuccca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gcaacuccca guacggccag      900

cagcaggacg ccuaccaggg cccccccccc cagcagggcu acccccccca gcagcagcag      960

uaccccggcc agcagggcua ccccggccag cagcagggcu acggccccuc ccagggcggc     1020

cccggccccc aguaccccaa cuacccccag ggccagggcc agcaguacgg cggcuaccgc     1080

cccacccagc ccggcccccc ccagcccccc cagcagcgcc ccuacggcua cgaccagauc     1140

augcccaaga agcccgccga ggacgagaac gacuccaagg gcgucuccga ggccuccggc     1200

ccccagaacg acggcaagca gcuccacccc cccggcaagg ccaacaucuc cgagaagauc     1260

aacaagcgcu ccggccccaa gcgcggcaag cacgccugga cccaccgccu ccgcgagcgc     1320

aagcagcucg ucaucuacga ggagaucucc gaccccgagg aggacgacga guga           1374


<210>  3587
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3587
augagcgugg ccuucgcugc acccagacag aggggcaagg gggagaucac cccugccgcg       60

auucagaaaa ugcuggacga uaacaaucac cucauacaau gcaucaugga cucccagaac      120

aagggaaaaa caucugaaug uucacaguac caacagaugc uucauacuaa ucuggucuau      180

uuggcuacga uugccgauag uaaccagaau augcagagcu uacugccagc accgcccacc      240

caaaacaugc cuaugggucc aggcgggaug aaucaguccg gacccccucc acccccucgg      300

ucucacaaca ugccaucgga cggcaugguu ggugggggac cgcccgcccc ucauaugcag      360

aaucagauga acggccaaau gccaggcccc aaucacaugc cuaugcaggg gccaggaccc      420

aaccagcuaa auaugacaaa cucaagcaug aauaugccga guuccucuca ugguagcaug      480

ggcggguaca accacuccgu gccuucaagu caaagcaugc ccguacagaa ccagaugacu      540

augucucagg gacaaccaau gggcaauuau gguccucgcc ccaacauguc caugcagcca      600

aaucaggggc ccaugaugca ccagcaaccu ccaucacagc aguacaacau gccgcaggga      660

ggcggccaac auuaucaggg gcagcagccc ccuaugggaa ugauggguca agugaaucag      720

ggcaaccaca ugauggggca gcgacaaauc ccacccuacc guccuccaca gcagggaccc      780

ccgcagcaau auagcggcca ggaggauuac uacggugacc aguauaguca ugggggccag      840

ggaccuccag aaggcaugaa ucaacaguac uaucccgaug ggaacucuca guacggacag      900

caacaggacg cuuaucaggg uccuccccca caacagggcu acccucccca gcagcaacag      960

uauccagggc agcagggaua cccgggccaa cagcaggguu acgggccuuc ccagggcgga     1020

cccggcccac aauaucccaa uuacccucag gggcagggac agcaauaugg uggcuacaga     1080

ccaacccagc ccgggccucc gcagccaccc caacagaggc cuuauggaua cgaucagauu     1140

augccaaaga aacccgcaga ggacgaaaac gauagcaagg gcgucucgga ggccucuggu     1200

ccucagaaug acgggaagca acuccacccg cccggcaaag cuaacaucuc cgagaagaua     1260

aauaaacggu caggaccaaa gcgcggcaaa cacgccugga cacauagacu gagggaacgg     1320

aagcagcuug ugaucuauga ggaaauuagu gauccugagg aggacgacga auga           1374


<210>  3588
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3588
augagcgugg ccuucgccgc ccccagacag agaggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcuggacga caacaaccac cugauccagu gcaucaugga cagccagaac      120

aagggcaaga ccagcgagug cagccaguac cagcagaugc ugcacaccaa ccugguguac      180

cuggccacca ucgccgacag caaccagaac augcagagcc ugcugcccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccagagcg gccccccccc cccccccaga      300

agccacaaca ugcccagcga cggcauggug ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuga acaugaccaa cagcagcaug aacaugccca gcagcagcca cggcagcaug      480

ggcggcuaca accacagcgu gcccagcagc cagagcaugc ccgugcagaa ccagaugacc      540

augagccagg gccagcccau gggcaacuac ggccccagac ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccagccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggugaaccag      720

ggcaaccaca ugaugggcca gagacagauc ccccccuaca gaccccccca gcagggcccc      780

ccccagcagu acagcggcca ggaggacuac uacggcgacc aguacagcca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gcaacagcca guacggccag      900

cagcaggacg ccuaccaggg cccccccccc cagcagggcu acccccccca gcagcagcag      960

uaccccggcc agcagggcua ccccggccag cagcagggcu acggccccag ccagggcggc     1020

cccggccccc aguaccccaa cuacccccag ggccagggcc agcaguacgg cggcuacaga     1080

cccacccagc ccggcccccc ccagcccccc cagcagagac ccuacggcua cgaccagauc     1140

augcccaaga agcccgccga ggacgagaac gacagcaagg gcgugagcga ggccagcggc     1200

ccccagaacg acggcaagca gcugcacccc cccggcaagg ccaacaucag cgagaagauc     1260

aacaagagaa gcggccccaa gagaggcaag cacgccugga cccacagacu gagagagaga     1320

aagcagcugg ugaucuacga ggagaucagc gaccccgagg aggacgacga guga           1374


<210>  3589
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYT-SSX-1__Homo_sapiens__BAF56182

<400>  3589
augagcgugg ccuucgcugc ccccagacag cggggcaagg gggagaucac cccugcggcu       60

auucagaaaa ugcuggacga uaacaaucac cucauccaau gcauuaugga cucccagaac      120

aagggaaaaa caucugaaug uagccaguac caacagaugc ugcauacgaa ucuugucuau      180

cuggccacca ucgccgauuc caaccagaau augcagucuc uccugccggc ucccccuaca      240

caaaacaugc ccaugggccc ugggggaaug aaucagagcg ggcccccucc gcccccucgc      300

ucccacaaca ugcccucuga cggcaugguu ggaggcggcc cucccgcccc gcauaugcag      360

aaucagauga acgggcaaau gccuggaccc aaucacaugc cuaugcaggg ccccgggccc      420

aaccagcuua auaugaccaa cagcuccaug aauaugccuu cuagcuccca uggaagcaug      480

ggcggguaca accacucugu gccguccagc caaucuaugc ccgugcagaa ccagaugaca      540

augucccagg gacaaccuau gggcaauuau ggccccagac cuaacaugag caugcagccc      600

aaucaggggc cgaugaugca ccagcaaccu cccucccagc aguacaacau gccucaggga      660

ggcgggcaac auuaucaggg acagcagccc ccuaugggca ugauggggca agucaaucag      720

ggaaaccaca ugaugggcca gcggcaaauu cccccguacc gcccucccca gcaggggccc      780

ccucagcaau auucuggcca ggaggauuac uacggagacc aguauagcca uggcgggcag      840

ggaccgcccg aaggcaugaa ucaacaguac uauccugaug ggaacuccca guacggccag      900

caacaggacg cuuaucaggg acccccuccc caacagggcu acccucccca gcagcaacag      960

uauccggggc agcagggaua cccuggccaa cagcaggggu acggacccag ccagggcggg     1020

ccuggccccc aauauccgaa uuacccucag ggacagggcc agcaauaugg gggauacaga     1080

cccacccagc cuggcccucc ccagcccccg caacagcggc ccuaugggua cgaucagauc     1140

augccuaaga aacccgccga ggacgaaaac gauucuaagg gaguguccga ggcgagcggc     1200

ccucagaaug acgggaagca acugcauccc ccuggcaaag ccaacaucuc ugagaagauu     1260

aauaaacgca gcggaccgaa gagaggcaaa cacgcuugga cacaccggcu ccgcgaaaga     1320

aagcagcugg uuaucuauga ggaaauuucc gaucccgagg aggacgacga auga           1374


<210>  3590
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-2__Homo_sapiens__A4PIV9

<400>  3590

Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr Gly Tyr Gln Gln Pro Ser 
    290                 295                 300                 


Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr Glu Asp Ser Ser Gln His 
305                 310                 315                 320 


Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala Tyr 
                325                 330                 335     


Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln Tyr 
            340                 345                 350         


Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro Ser 
        355                 360                 365             


Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln Gly 
    370                 375                 380                 


Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met Pro Lys Lys Pro 
                405                 410                 415     


Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu Ala Ser Gly Pro 
            420                 425                 430         


Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys Pro Thr Thr Ser 
        435                 440                 445             


Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly Glu His Ala Trp 
    450                 455                 460                 


Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile 
465                 470                 475                 480 


Ser Asp Pro Glu Glu Asp Asp Glu 
                485             


<210>  3591
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3591
augucugugg cuuucgcggc cccgaggcag cgaggcaagg gggagaucac ucccgcugcg       60

auucagaaga uguuggauga caauaaccau cuuauucagu guauaaugga cucucagaau      120

aaaggaaaga ccucagagug uucucaguau cagcagaugu ugcacacaaa cuugguauac      180

cuugcuacaa uagcagauuc uaaucaaaau augcagucuc uuuuaccagc accacccaca      240

cagaauaugc cuaugggucc uggagggaug aaucagagcg gcccuccccc accuccacgc      300

ucucacaaca ugccuucaga uggaauggua gguggggguc cuccugcacc gcacaugcag      360

aaccagauga acggccagau gccugggccu aaccauaugc cuaugcaggg accuggaccc      420

aaucaacuca auaugacaaa caguuccaug aauaugccuu caaguagcca uggauccaug      480

ggagguuaca accauucugu gccaucaucg cagagcaugc caguacagaa ucagaugaca      540

augagucagg gacaaccaau gggaaacuau ggucccagac caaauaugag uaugcagcca      600

aaccaagguc caaugaugca ucagcagccu ccuucucagc aauacaauau gccacaggga      660

ggcggacagc auuaccaagg acagcagcca ccuaugggga ugauggguca aguuaaccaa      720

ggcaaucaua ugauggguca gagacagauu ccucccuaua gaccuccuca acagggccca      780

ccacagcagu acucaggcca ggaagacuau uacggggacc aauacaguca ugguggacaa      840

gguccuccag aaggcaugaa ccagcaauau uacccugaug gucauaauga uuacgguuau      900

cagcaaccgu cguauccuga acaaggcuac gauaggccuu augaggauuc cucacaacau      960

uacuacgaag gaggaaauuc acaguauggc caacagcaag augcauacca gggaccaccu     1020

ccacaacagg gauauccacc ccagcagcag caguacccag ggcagcaagg uuacccagga     1080

cagcagcagg gcuacggucc uucacagggu gguccagguc cucaguaucc uaacuaccca     1140

cagggacaag gucagcagua uggaggauau agaccaacac agccuggacc accacagcca     1200

ccccagcaga ggccuuaugg auaugaccag aucaugccca agaagccagc agaggaagga     1260

aaugauucgg aggaagugcc agaagcaucu ggcccacaaa augaugggaa agagcugugc     1320

cccccgggaa aaccaacuac cucugagaag auucacgaga gaucuggacc caaaaggggg     1380

gaacaugccu ggacccacag acugcgugag agaaaacagc uggugauuua ugaagagauc     1440

agcgacccug aggaagauga cgaguaa                                         1467


<210>  3592
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3592
augagcgugg ccuucgccgc gccccgccag cggggcaagg gggagaucac cccggccgcc       60

auccagaaga ugcuggacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccagcgagug cucccaguac cagcagaugc ugcacacgaa ccuggucuac      180

cucgccacca ucgccgacag caaccagaac augcaguccc ugcugcccgc gccccccacc      240

cagaacaugc cgauggggcc cggcgggaug aaccagagcg gccccccccc gcccccccgc      300

ucccacaaca ugcccagcga cggcauggug gggggcgggc cgcccgcccc ccacaugcag      360

aaccagauga acggccagau gcccgggccg aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccagcaug aacaugccgu ccagcuccca cgggagcaug      480

ggcggguaca accacuccgu gcccagcucc cagagcaugc ccguccagaa ccagaugacg      540

augucccagg gccagcccau gggcaacuac gggccgcggc ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccg cccagccagc aguacaacau gccccagggg      660

ggcgggcagc acuaccaggg ccagcagccg cccaugggca ugauggggca ggugaaccag      720

ggcaaccaca ugauggggca gcgccagauc ccccccuacc ggccgcccca gcagggcccc      780

ccccagcagu acuccgggca ggaggacuac uacggcgacc aguacagcca cggcgggcag      840

ggcccgcccg aggggaugaa ccagcaguac uaccccgacg gccacaacga cuacggguac      900

cagcagcccu ccuacccgga gcagggcuac gaccgccccu acgaggacag cucccagcac      960

uacuacgagg gcgggaacag ccaguacggc cagcagcagg acgccuacca ggggcccccc     1020

ccgcagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg guacccgggc     1080

cagcagcagg gguacggccc cucccagggg ggccccggcc cccaguaccc gaacuacccc     1140

caggggcagg gccagcagua cgggggcuac cggcccaccc agccggggcc cccccagccc     1200

ccgcagcagc gccccuacgg cuacgaccag aucaugccca agaagcccgc cgaggagggc     1260

aacgacagcg aggaggugcc ggaggcgucc gggccccaga acgacggcaa ggagcugugc     1320

ccccccggga agccgaccac cagcgagaag auccacgagc gguccggccc caagcgcggg     1380

gagcacgccu ggacgcaccg gcugcgcgag cggaagcagc ucgucaucua cgaggagauc     1440

agcgaccccg aggaggacga cgaguga                                         1467


<210>  3593
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3593
auguccgucg ccuucgccgc cccccgccag cgcggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcucgacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccuccgagug cucccaguac cagcagaugc uccacaccaa ccucgucuac      180

cucgccacca ucgccgacuc caaccagaac augcaguccc uccuccccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccaguccg gccccccccc ccccccccgc      300

ucccacaaca ugcccuccga cggcaugguc ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccuccaug aacaugcccu ccuccuccca cggcuccaug      480

ggcggcuaca accacuccgu ccccuccucc caguccaugc ccguccagaa ccagaugacc      540

augucccagg gccagcccau gggcaacuac ggcccccgcc ccaacauguc caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccucccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggucaaccag      720

ggcaaccaca ugaugggcca gcgccagauc ccccccuacc gcccccccca gcagggcccc      780

ccccagcagu acuccggcca ggaggacuac uacggcgacc aguacuccca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gccacaacga cuacggcuac      900

cagcagcccu ccuaccccga gcagggcuac gaccgccccu acgaggacuc cucccagcac      960

uacuacgagg gcggcaacuc ccaguacggc cagcagcagg acgccuacca gggccccccc     1020

ccccagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg cuaccccggc     1080

cagcagcagg gcuacggccc cucccagggc ggccccggcc cccaguaccc caacuacccc     1140

cagggccagg gccagcagua cggcggcuac cgccccaccc agcccggccc cccccagccc     1200

ccccagcagc gccccuacgg cuacgaccag aucaugccca agaagcccgc cgaggagggc     1260

aacgacuccg aggagguccc cgaggccucc ggcccccaga acgacggcaa ggagcucugc     1320

ccccccggca agcccaccac cuccgagaag auccacgagc gcuccggccc caagcgcggc     1380

gagcacgccu ggacccaccg ccuccgcgag cgcaagcagc ucgucaucua cgaggagauc     1440

uccgaccccg aggaggacga cgaguga                                         1467


<210>  3594
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3594
augagcgugg ccuucgcugc acccagacag aggggcaagg gggagaucac cccugccgcg       60

auucagaaaa ugcuggacga uaacaaucac cucauacaau gcaucaugga cucccagaac      120

aagggaaaaa caucugaaug cucacaguac caacagaugc uucauacuaa ucuggucuau      180

uuggcuacga uugccgauag uaaccagaau augcagagcu uacugccagc accgcccacc      240

caaaacaugc cuaugggucc aggcgggaug aaucaguccg gacccccucc acccccucgg      300

ucucacaaca ugccaucgga cggcaugguu ggugggggac cgcccgcccc ucauaugcag      360

aaucagauga acggccaaau gccaggcccc aaucacaugc cuaugcaggg gccaggaccc      420

aaccagcuaa auaugacaaa cucaagcaug aauaugccga guuccucuca ugguagcaug      480

ggcggguaca accacuccgu gccuucaagu caaagcaugc ccguacagaa ccagaugacu      540

augucucagg gacaaccaau gggcaauuau gguccucgcc ccaacauguc caugcagcca      600

aaucaggggc ccaugaugca ccagcaaccu ccaucacagc aguacaacau gccgcaggga      660

ggcggccaac auuaucaggg gcagcagccc ccuaugggaa ugauggguca agugaaucag      720

ggcaaccaca ugauggggca gcgacaaauc ccacccuacc guccuccaca gcagggaccc      780

ccgcagcaau auagcggcca ggaggauuac uacggugacc aguauaguca ugggggccag      840

ggaccuccag aaggcaugaa ucaacaguac uaucccgaug ggcacaacga cuacggauau      900

cagcagccuu cuuaccccga gcaagguuau gauagaccau acgaagacuc cagccagcac      960

uacuaugagg gcggaaauuc gcaguacggg caacagcagg augcuuauca gggcccuccc     1020

ccacaacagg guuacccgcc ucagcagcaa caguaucccg ggcagcaggg cuacccagga     1080

caacagcagg gcuaugggcc cucucaggga gguccuggcc cacaauaccc caacuacccu     1140

caggggcagg gacaacagua uggcgguuac aggccgaccc agccagggcc cccucagcca     1200

ccccaacagc ggccuuaugg cuacgaccag auuaugccga agaaacccgc agaggaagga     1260

aaugauuccg aggaaguccc agaggccuca ggcccucaga acgacgggaa ggagcucugu     1320

cccccaggaa agccuacaac cagugagaaa auccaugaac gcagcggccc caagagaggu     1380

gaacacgcuu ggacucauag gcugcgggag cgcaaacaac uugugauaua ugaagagauc     1440

uccgacccag aggaagauga cgaguga                                         1467


<210>  3595
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3595
augagcgugg ccuucgccgc ccccagacag agaggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcuggacga caacaaccac cugauccagu gcaucaugga cagccagaac      120

aagggcaaga ccagcgagug cagccaguac cagcagaugc ugcacaccaa ccugguguac      180

cuggccacca ucgccgacag caaccagaac augcagagcc ugcugcccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccagagcg gccccccccc cccccccaga      300

agccacaaca ugcccagcga cggcauggug ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuga acaugaccaa cagcagcaug aacaugccca gcagcagcca cggcagcaug      480

ggcggcuaca accacagcgu gcccagcagc cagagcaugc ccgugcagaa ccagaugacc      540

augagccagg gccagcccau gggcaacuac ggccccagac ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccagccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggugaaccag      720

ggcaaccaca ugaugggcca gagacagauc ccccccuaca gaccccccca gcagggcccc      780

ccccagcagu acagcggcca ggaggacuac uacggcgacc aguacagcca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gccacaacga cuacggcuac      900

cagcagccca gcuaccccga gcagggcuac gacagacccu acgaggacag cagccagcac      960

uacuacgagg gcggcaacag ccaguacggc cagcagcagg acgccuacca gggccccccc     1020

ccccagcagg gcuacccccc ccagcagcag caguaccccg gccagcaggg cuaccccggc     1080

cagcagcagg gcuacggccc cagccagggc ggccccggcc cccaguaccc caacuacccc     1140

cagggccagg gccagcagua cggcggcuac agacccaccc agcccggccc cccccagccc     1200

ccccagcaga gacccuacgg cuacgaccag aucaugccca agaagcccgc cgaggagggc     1260

aacgacagcg aggaggugcc cgaggccagc ggcccccaga acgacggcaa ggagcugugc     1320

ccccccggca agcccaccac cagcgagaag auccacgaga gaagcggccc caagagaggc     1380

gagcacgccu ggacccacag acugagagag agaaagcagc uggugaucua cgaggagauc     1440

agcgaccccg aggaggacga cgaguga                                         1467


<210>  3596
<211>  1467
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYT-SSX-2__Homo_sapiens__BAF56183

<400>  3596
augagcgugg ccuucgcugc ccccagacag cggggcaagg gggagaucac cccugcggcu       60

auucagaaaa ugcuggacga uaacaaucac cucauccaau gcauuaugga cucccagaac      120

aagggaaaaa caucugaaug uagccaguac caacagaugc ugcauacgaa ucuugucuau      180

cuggccacca ucgccgauuc caaccagaau augcagucuc uccugccggc ucccccuaca      240

caaaacaugc ccaugggccc ugggggaaug aaucagagcg ggcccccucc gcccccucgc      300

ucccacaaca ugcccucuga cgggaugguu ggaggcggcc cucccgcccc gcauaugcag      360

aaucagauga acgggcaaau gccuggaccc aaucacaugc cuaugcaggg ccccgggccc      420

aaccagcuua auaugaccaa cagcuccaug aauaugccuu cuagcuccca uggaagcaug      480

ggcggguaca accacucugu gccguccagc caaucuaugc ccgugcagaa ccagaugaca      540

augucccagg gacaaccuau gggcaauuau ggccccagac cuaacaugag caugcagccc      600

aaucaggggc cgaugaugca ccagcaaccu cccucccagc aguacaacau gccucaggga      660

ggcgggcaac auuaucaggg acagcagccc ccuaugggca ugauggggca agucaaucag      720

ggaaaccaca ugaugggcca gcggcaaauu cccccguacc gcccucccca gcaggggccc      780

ccucagcaau auucugggca ggaggauuac uacggagacc aguauagcca uggcgggcag      840

ggaccgcccg aaggcaugaa ucaacaguac uauccugaug ggcacaacga cuacggcuau      900

cagcagcccu ccuacccuga gcaaggauau gauagacccu acgaagacag cucucagcac      960

uacuaugagg gcggcaauuc ccaguacgga caacagcagg augcuuauca gggcccuccc     1020

ccgcaacagg gguacccucc ccagcagcaa caguauccug gacagcaggg cuaccccggg     1080

caacagcagg gcuauggacc gagccagggc gggccuggac cccaauaccc uaacuacccc     1140

cagggccagg ggcaacagua uggaggcuac cggcccaccc agccugggcc gccccagccu     1200

ccccaacagc gcccuuaugg cuacgaccag aucaugccca agaaaccugc cgaggaagga     1260

aaugauucug aggaagugcc ggaggcgagc ggcccccaga acgacgggaa ggagcugugc     1320

ccucccggaa agccuacaac cuccgagaaa auccaugaaa gaucuggccc caagcggggc     1380

gaacacgccu ggacgcaucg ccucagagag cggaaacaac ugguuauuua ugaagagauc     1440

agcgacccgg aggaagauga cgaguga                                         1467


<210>  3597
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-2__Homo_sapiens__A4PIW0

<400>  3597

Met Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly Lys Gly Glu Ile 
1               5                   10                  15      


Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn Asn His Leu Ile 
            20                  25                  30          


Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr Ser Glu Cys Ser 
        35                  40                  45              


Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr Leu Ala Thr Ile 
    50                  55                  60                  


Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr 
65                  70                  75                  80  


Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln Ser Gly Pro Pro 
                85                  90                  95      


Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly Met Val Gly Gly 
            100                 105                 110         


Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn Gly Gln Met Pro 
        115                 120                 125             


Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro Asn Gln Leu Asn 
    130                 135                 140                 


Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser His Gly Ser Met 
145                 150                 155                 160 


Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser Met Pro Val Gln 
                165                 170                 175     


Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly Asn Tyr Gly Pro 
            180                 185                 190         


Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro Met Met His Gln 
        195                 200                 205             


Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly Gly Gly Gln His 
    210                 215                 220                 


Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly Gln Val Asn Gln 
225                 230                 235                 240 


Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro Tyr Arg Pro Pro 
                245                 250                 255     


Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu Asp Tyr Tyr Gly 
            260                 265                 270         


Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu Gly Met Asn Gln 
        275                 280                 285             


Gln Tyr Tyr Pro Asp Gly Asn Ser Gln Tyr Gly Gln Gln Gln Asp Ala 
    290                 295                 300                 


Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln Gln Gln Gln 
305                 310                 315                 320 


Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Pro 
                325                 330                 335     


Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro Gln Gly Gln 
            340                 345                 350         


Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly Pro Pro Gln 
        355                 360                 365             


Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met Pro Lys Lys 
    370                 375                 380                 


Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu Ala Ser Gly 
385                 390                 395                 400 


Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys Pro Thr Thr 
                405                 410                 415     


Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly Glu His Ala 
            420                 425                 430         


Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu 
        435                 440                 445             


Ile Ser Asp Pro Glu Glu Asp Asp Glu 
    450                 455         


<210>  3598
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3598
augucugugg cuuucgcggc cccgaggcag cgaggcaagg gggagaucac ucccgcugcg       60

auucagaaga uguuggauga caauaaccau cuuauucagu guauaaugga cucucagaau      120

aaaggaaaga ccucagagug uucucaguau cagcagaugu ugcacacaaa cuugguauac      180

cuugcuacaa uagcagauuc uaaucaaaau augcagucuc uuuuaccagc accacccaca      240

cagaauaugc cuaugggucc uggagggaug aaucagagcg gcccuccccc accuccacgc      300

ucucacaaca ugccuucaga uggaauggua gguggggguc cuccugcacc gcacaugcag      360

aaccagauga acggccagau gccugggccu aaccauaugc cuaugcaggg accuggaccc      420

aaucaacuca auaugacaaa caguuccaug aauaugccuu caaguagcca uggauccaug      480

ggagguuaca accauucugu gccaucaucg cagagcaugc caguacagaa ucagaugaca      540

augagucagg gacaaccaau gggaaacuau ggucccagac caaauaugag uaugcagcca      600

aaccaagguc caaugaugca ucagcagccu ccuucucagc aauacaauau gccacaggga      660

ggcggacagc auuaccaagg acagcagcca ccuaugggga ugauggguca aguuaaccaa      720

ggcaaucaua ugauggguca gagacagauu ccucccuaua gaccuccuca acagggccca      780

ccacagcagu acucaggcca ggaagacuau uacggggacc aauacaguca ugguggacaa      840

gguccuccag aaggcaugaa ccagcaauau uacccugaug gaaauucaca guauggccaa      900

cagcaagaug cauaccaggg accaccucca caacagggau auccacccca gcagcagcag      960

uacccagggc agcaagguua cccaggacag cagcagggcu acgguccuuc acaggguggu     1020

ccagguccuc aguauccuaa cuacccacag ggacaagguc agcaguaugg aggauauaga     1080

ccaacacagc cuggaccacc acagccaccc cagcagaggc cuuauggaua ugaccagauc     1140

augcccaaga agccagcaga ggaaggaaau gauucggagg aagugccaga agcaucuggc     1200

ccacaaaaug augggaaaga gcugugcccc ccgggaaaac caacuaccuc ugagaagauu     1260

cacgagagau cuggacccaa aaggggggaa caugccugga cccacagacu gcgugagaga     1320

aaacagcugg ugauuuauga agagaucagc gacccugagg aagaugacga guaa           1374


<210>  3599
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3599
augagcgugg ccuucgccgc gccccgccag cggggcaagg gggagaucac cccggccgcc       60

auccagaaga ugcuggacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccagcgagug cucccaguac cagcagaugc ugcacacgaa ccuggucuac      180

cucgccacca ucgccgacag caaccagaac augcaguccc ugcugcccgc gccccccacc      240

cagaacaugc cgauggggcc cggcgggaug aaccagagcg gccccccccc gcccccccgc      300

ucccacaaca ugcccagcga cggcauggug gggggcgggc cgcccgcccc ccacaugcag      360

aaccagauga acggccagau gcccgggccg aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccagcaug aacaugccgu ccagcuccca cgggagcaug      480

ggcggguaca accacuccgu gcccagcucc cagagcaugc ccguccagaa ccagaugacg      540

augucccagg gccagcccau gggcaacuac gggccgcggc ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccg cccagccagc aguacaacau gccccagggg      660

ggcgggcagc acuaccaggg ccagcagccg cccaugggca ugauggggca ggugaaccag      720

ggcaaccaca ugauggggca gcgccagauc ccccccuacc ggccgcccca gcagggcccc      780

ccccagcagu acuccgggca ggaggacuac uacggcgacc aguacagcca cggcgggcag      840

ggcccgcccg aggggaugaa ccagcaguac uaccccgacg gcaacuccca guacgggcag      900

cagcaggacg ccuaccaggg ccccccgccc cagcagggcu acccccccca gcagcagcag      960

uacccggggc agcagggcua ccccgggcag cagcagggcu acggccccag ccaggggggc     1020

cccgggccgc aguaccccaa cuacccccag ggccaggggc agcaguacgg cggcuaccgc     1080

cccacccagc cggggccccc ccagccgccc cagcagcggc ccuacggcua cgaccagauc     1140

augcccaaga agccggccga ggaggggaac gacuccgagg aggugcccga ggcgagcggc     1200

ccccagaacg acgggaagga gcugugcccc ccgggcaagc ccaccaccuc cgagaagauc     1260

cacgagcgca gcggccccaa gcggggggag cacgccugga cgcaccgccu gcgggagcgc     1320

aagcagcucg ucaucuacga ggagaucucc gaccccgagg aggacgacga guga           1374


<210>  3600
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3600
auguccgucg ccuucgccgc cccccgccag cgcggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcucgacga caacaaccac cucauccagu gcaucaugga cucccagaac      120

aagggcaaga ccuccgagug cucccaguac cagcagaugc uccacaccaa ccucgucuac      180

cucgccacca ucgccgacuc caaccagaac augcaguccc uccuccccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccaguccg gccccccccc ccccccccgc      300

ucccacaaca ugcccuccga cggcaugguc ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuca acaugaccaa cuccuccaug aacaugcccu ccuccuccca cggcuccaug      480

ggcggcuaca accacuccgu ccccuccucc caguccaugc ccguccagaa ccagaugacc      540

augucccagg gccagcccau gggcaacuac ggcccccgcc ccaacauguc caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccucccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggucaaccag      720

ggcaaccaca ugaugggcca gcgccagauc ccccccuacc gcccccccca gcagggcccc      780

ccccagcagu acuccggcca ggaggacuac uacggcgacc aguacuccca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gcaacuccca guacggccag      900

cagcaggacg ccuaccaggg cccccccccc cagcagggcu acccccccca gcagcagcag      960

uaccccggcc agcagggcua ccccggccag cagcagggcu acggccccuc ccagggcggc     1020

cccggccccc aguaccccaa cuacccccag ggccagggcc agcaguacgg cggcuaccgc     1080

cccacccagc ccggcccccc ccagcccccc cagcagcgcc ccuacggcua cgaccagauc     1140

augcccaaga agcccgccga ggagggcaac gacuccgagg agguccccga ggccuccggc     1200

ccccagaacg acggcaagga gcucugcccc cccggcaagc ccaccaccuc cgagaagauc     1260

cacgagcgcu ccggccccaa gcgcggcgag cacgccugga cccaccgccu ccgcgagcgc     1320

aagcagcucg ucaucuacga ggagaucucc gaccccgagg aggacgacga guga           1374


<210>  3601
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3601
augagcgugg ccuucgcugc acccagacag aggggcaagg gggagaucac cccugccgcg       60

auucagaaaa ugcuggacga uaacaaucac cucauacaau gcaucaugga cucccagaac      120

aagggaaaaa caucugaaug cucacaguac caacagaugc uucauacuaa ucuggucuau      180

uuggcuacga uugccgauag uaaccagaau augcagagcu uacugccagc accgcccacc      240

caaaacaugc cuaugggucc aggcgggaug aaucaguccg gacccccucc acccccucgg      300

ucucacaaca ugccaucgga cggcaugguu ggugggggac cgcccgcccc ucauaugcag      360

aaucagauga acggccaaau gccaggcccc aaucacaugc cuaugcaggg gccaggaccc      420

aaccagcuaa auaugacaaa cucaagcaug aauaugccga guuccucuca ugguagcaug      480

ggcggguaca accacuccgu gccuucaagu caaagcaugc ccguacagaa ccagaugacu      540

augucucagg gacaaccaau gggcaauuau gguccucgcc ccaacauguc caugcagcca      600

aaucaggggc ccaugaugca ccagcaaccu ccaucacagc aguacaacau gccgcaggga      660

ggcggccaac auuaucaggg gcagcagccc ccuaugggaa ugauggguca agugaaucag      720

ggcaaccaca ugauggggca gcgacaaauc ccacccuacc guccuccaca gcagggaccc      780

ccgcagcaau auagcggcca ggaggauuac uacggugacc aguauaguca ugggggccag      840

ggaccuccag aaggcaugaa ucaacaguac uaucccgaug ggaacucuca guacggacag      900

caacaggacg cuuaucaggg uccuccccca caacagggcu acccucccca gcagcaacag      960

uauccagggc agcagggaua cccgggccaa cagcaggguu acgggccuuc ccagggcgga     1020

cccggcccac aauaucccaa uuacccucag gggcagggac agcaauaugg uggcuacaga     1080

ccaacccagc ccgggccucc gcagccaccc caacagaggc cuuauggaua cgaucagauu     1140

augccaaaga aacccgcaga ggaaggcaac gacagcgagg aggucccuga agccucgggu     1200

ccgcagaaug augggaagga gcucuguccc ccaggcaagc cuacaaccuc ugagaaaauc     1260

cacgaacggu ccggacccaa gcgcggcgag cacgcuugga cucauagacu gagggaacgg     1320

aaacaacuug ugauauauga ggaaaucuca gacccagagg aagaugacga guga           1374


<210>  3602
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3602
augagcgugg ccuucgccgc ccccagacag agaggcaagg gcgagaucac ccccgccgcc       60

auccagaaga ugcuggacga caacaaccac cugauccagu gcaucaugga cagccagaac      120

aagggcaaga ccagcgagug cagccaguac cagcagaugc ugcacaccaa ccugguguac      180

cuggccacca ucgccgacag caaccagaac augcagagcc ugcugcccgc cccccccacc      240

cagaacaugc ccaugggccc cggcggcaug aaccagagcg gccccccccc cccccccaga      300

agccacaaca ugcccagcga cggcauggug ggcggcggcc cccccgcccc ccacaugcag      360

aaccagauga acggccagau gcccggcccc aaccacaugc ccaugcaggg ccccggcccc      420

aaccagcuga acaugaccaa cagcagcaug aacaugccca gcagcagcca cggcagcaug      480

ggcggcuaca accacagcgu gcccagcagc cagagcaugc ccgugcagaa ccagaugacc      540

augagccagg gccagcccau gggcaacuac ggccccagac ccaacaugag caugcagccc      600

aaccagggcc ccaugaugca ccagcagccc cccagccagc aguacaacau gccccagggc      660

ggcggccagc acuaccaggg ccagcagccc cccaugggca ugaugggcca ggugaaccag      720

ggcaaccaca ugaugggcca gagacagauc ccccccuaca gaccccccca gcagggcccc      780

ccccagcagu acagcggcca ggaggacuac uacggcgacc aguacagcca cggcggccag      840

ggcccccccg agggcaugaa ccagcaguac uaccccgacg gcaacagcca guacggccag      900

cagcaggacg ccuaccaggg cccccccccc cagcagggcu acccccccca gcagcagcag      960

uaccccggcc agcagggcua ccccggccag cagcagggcu acggccccag ccagggcggc     1020

cccggccccc aguaccccaa cuacccccag ggccagggcc agcaguacgg cggcuacaga     1080

cccacccagc ccggcccccc ccagcccccc cagcagagac ccuacggcua cgaccagauc     1140

augcccaaga agcccgccga ggagggcaac gacagcgagg aggugcccga ggccagcggc     1200

ccccagaacg acggcaagga gcugugcccc cccggcaagc ccaccaccag cgagaagauc     1260

cacgagagaa gcggccccaa gagaggcgag cacgccugga cccacagacu gagagagaga     1320

aagcagcugg ugaucuacga ggagaucagc gaccccgagg aggacgacga guga           1374


<210>  3603
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SYT-SSX-2__Homo_sapiens__BAF56184

<400>  3603
augagcgugg ccuucgcugc ccccagacag cggggcaagg gggagaucac cccugcggcu       60

auucagaaaa ugcuggacga uaacaaucac cucauccaau gcauuaugga cucccagaac      120

aagggaaaaa caucugaaug uagccaguac caacagaugc ugcauacgaa ucuugucuau      180

cuggccacca ucgccgauuc caaccagaau augcagucuc uccugccggc ucccccuaca      240

caaaacaugc ccaugggccc ugggggaaug aaucagagcg ggcccccucc gcccccucgc      300

ucccacaaca ugcccucuga cggcaugguu ggaggcggcc cucccgcccc gcauaugcag      360

aaucagauga acgggcaaau gccuggaccc aaucacaugc cuaugcaggg ccccgggccc      420

aaccagcuua auaugaccaa cagcuccaug aauaugccuu cuagcuccca uggaagcaug      480

ggcggguaca accacucugu gccguccagc caaucuaugc ccgugcagaa ccagaugaca      540

augucccagg gacaaccuau gggcaauuau ggccccagac cuaacaugag caugcagccc      600

aaucaggggc cgaugaugca ccagcaaccu cccucccagc aguacaacau gccucaggga      660

ggcgggcaac auuaucaggg acagcagccc ccuaugggca ugauggggca agucaaucag      720

ggaaaccaca ugaugggcca gcggcaaauu cccccguacc gcccucccca gcaggggccc      780

ccucagcaau auucuggcca ggaggauuac uacggagacc aguauagcca uggcgggcag      840

ggaccgcccg aaggcaugaa ucaacaguac uauccugaug ggaacuccca guacggccag      900

caacaggacg cuuaucaggg acccccuccc caacagggcu acccucccca gcagcaacag      960

uauccggggc agcagggaua cccuggccaa cagcaggggu acggacccag ccagggcggg     1020

ccuggccccc aauauccgaa uuacccucag ggacagggcc agcaauaugg gggauacaga     1080

cccacccagc cuggcccucc ccagcccccg caacagcggc ccuaugggua cgaucagauc     1140

augccuaaga aacccgccga ggaaggaaac gacucugagg aggugccuga agcguccggc     1200

ccccagaaug augggaagga gcugugcccu ccgggcaagc ccacaaccag cgagaaaauc     1260

cacgaacgcu cuggaccuaa gagaggcgag cacgccugga cgcaucggcu ccgcgaaaga     1320

aaacaacugg uuauuuauga ggaaaucagc gaccccgagg aagaugacga guga           1374


<210>  3604
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TARP__Homo_sapiens__Q0VGM3

<400>  3604

Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro 
1               5                   10                  15      


Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn 
            20                  25                  30          


Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr 
        35                  40                  45              


Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn 
    50                  55                  60                  


Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr 
65                  70                  75                  80  


Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys 
                85                  90                  95      


Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
            100                 105                 110     


<210>  3605
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TARP__Homo_sapiens__AAI05590

<400>  3605
augaagacua acgacacaua caugaaauuu agcugguuaa cggugccaga aaagucacug       60

gacaaagaac acagauguau cgucagacau gagaauaaua aaaacggagu ugaucaagaa      120

auuaucuuuc cuccaauaaa gacagauguc aucacaaugg aucccaaaga caauuguuca      180

aaagaugcaa augauacacu acugcugcag cucacaaaca ccucugcaua uuacauguac      240

cuccuccugc uccucaagag uguggucuau uuugccauca ucaccugcug ucugcuuaga      300

agaacggcuu ucugcugcaa uggagagaaa ucauaa                                336


<210>  3606
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TARP__Homo_sapiens__AAI05590

<400>  3606
augaagacca acgacaccua caugaaguuc agcuggcuga ccgugcccga gaagucccuc       60

gacaaggagc accgcugcau cguccggcac gagaacaaca agaacggcgu ggaccaggag      120

aucaucuucc cgcccaucaa gaccgacgug aucaccaugg accccaagga caacugcagc      180

aaggacgcca acgacacccu gcugcuccag cugacgaaca ccuccgccua cuacauguac      240

cugcuccugc ugcucaagag cgucguguac uucgcgauca ucacgugcug ccugcugcgc      300

cggaccgccu ucugcugcaa cggggagaag uccuga                                336


<210>  3607
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TARP__Homo_sapiens__AAI05590

<400>  3607
augaagacca acgacaccua caugaaguuc uccuggcuca ccguccccga gaagucccuc       60

gacaaggagc accgcugcau cguccgccac gagaacaaca agaacggcgu cgaccaggag      120

aucaucuucc cccccaucaa gaccgacguc aucaccaugg accccaagga caacugcucc      180

aaggacgcca acgacacccu ccuccuccag cucaccaaca ccuccgccua cuacauguac      240

cuccuccucc uccucaaguc cgucgucuac uucgccauca ucaccugcug ccuccuccgc      300

cgcaccgccu ucugcugcaa cggcgagaag uccuga                                336


<210>  3608
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TARP__Homo_sapiens__AAI05590

<400>  3608
augaagacca acgacacaua caugaaauuc agcuggcuga cugugcccga gaagucccuc       60

gauaaagagc acagaugcau cgucaggcau gagaauaaca agaauggcgu ugaccaggaa      120

auuauauuuc cuccaaucaa aacggaugug auuaccaugg acccgaagga uaacuguucu      180

aaggacgcca augauacacu ucuguugcaa uuaacuaaca ccucagcuua uuacauguau      240

cugcuacucc ugcuuaaaag uguaguguac uucgcaauca uuacaugcug ucuguugcgg      300

cgcaccgccu uuugcuguaa uggggaaaag agcuga                                336


<210>  3609
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TARP__Homo_sapiens__AAI05590

<400>  3609
augaagacca acgacaccua caugaaguuc agcuggcuga ccgugcccga gaagagccug       60

gacaaggagc acagaugcau cgugagacac gagaacaaca agaacggcgu ggaccaggag      120

aucaucuucc cccccaucaa gaccgacgug aucaccaugg accccaagga caacugcagc      180

aaggacgcca acgacacccu gcugcugcag cugaccaaca ccagcgccua cuacauguac      240

cugcugcugc ugcugaagag cgugguguac uucgccauca ucaccugcug ccugcugaga      300

agaaccgccu ucugcugcaa cggcgagaag agcuga                                336


<210>  3610
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TARP__Homo_sapiens__AAI05590

<400>  3610
augaagacca acgacacaua caugaaauuc agcuggcuga cggugcccga gaagucccuc       60

gauaaagaac acagaugcau cguccggcau gagaauaaca agaauggcgu ugaccaggaa      120

auuaucuuuc cuccgauuaa aaccgaugug aucacaaugg accccaagga uaacuguucu      180

aaggacgcca augauacccu gcuucugcaa cucacaaaca ccagcgcuua uuacauguau      240

cugcuucugc uccugaaauc cguggucuac uucgccauua ucacaugcug ucugcuccgc      300

agaaccgcgu uuugcuguaa uggggagaag ucuuga                                336


<210>  3611
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCRg__Homo_sapiens__A2JGV3

<400>  3611

Met Gln Met Phe Pro Pro Ser Pro Leu Phe Phe Phe Leu Gln Leu Leu 
1               5                   10                  15      


Lys Gln Ser Ser Arg Arg Leu Glu His Thr Phe Val Phe Leu Arg Asn 
            20                  25                  30          


Phe Ser Leu Met Leu Leu Arg Tyr Ile Gly Lys Lys Arg Arg Ala Thr 
        35                  40                  45              


Arg Phe Trp Asp Pro Arg Arg Gly Thr Pro 
    50                  55              


<210>  3612
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TCRg__Homo_sapiens__AAG29337

<400>  3612
augcagaugu uucccccaag cccacuauuu uucuuccuuc aauugcugaa acaaagcucc       60

agaaggcugg aacauaccuu ugucuucuug agaaauuuuu cccugauguu auuaagauac      120

auuggcaaga aaagaagagc aacacgauuc ugggauccca ggaggggaac accauga         177


<210>  3613
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TCRg__Homo_sapiens__AAG29337

<400>  3613
augcagaugu ucccgcccag cccccuguuc uucuuccucc agcugcugaa gcaguccagc       60

cgccggcucg agcacaccuu cguguuccug cgcaacuucu cccugaugcu ccugcgguac      120

aucggcaaga agcgccgggc cacccgcuuc ugggaccccc ggcgcgggac gcccuga         177


<210>  3614
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TCRg__Homo_sapiens__AAG29337

<400>  3614
augcagaugu ucccccccuc cccccucuuc uucuuccucc agcuccucaa gcaguccucc       60

cgccgccucg agcacaccuu cgucuuccuc cgcaacuucu cccucaugcu ccuccgcuac      120

aucggcaaga agcgccgcgc cacccgcuuc ugggaccccc gccgcggcac ccccuga         177


<210>  3615
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TCRg__Homo_sapiens__AAG29337

<400>  3615
augcagaugu uucccccuag cccacuguuc uucuuucucc aacuucugaa gcaguccucu       60

agaagguugg agcacaccuu cguguuuuua cggaacuucu cacugaugcu acuccgcuac      120

aucggcaaaa agcgacgugc cacaagauuu ugggacccga ggcgggggac ucccuga         177


<210>  3616
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TCRg__Homo_sapiens__AAG29337

<400>  3616
augcagaugu ucccccccag cccccuguuc uucuuccugc agcugcugaa gcagagcagc       60

agaagacugg agcacaccuu cguguuccug agaaacuuca gccugaugcu gcugagauac      120

aucggcaaga agagaagagc caccagauuc ugggacccca gaagaggcac ccccuga         177


<210>  3617
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TCRg__Homo_sapiens__AAG29337

<400>  3617
augcagaugu uucccccuag cccgcuguuc uucuuucucc aacugcuuaa gcaguccucu       60

agacggcugg agcacaccuu cguguuucuc cgcaacuuca gccugaugcu ucugagauac      120

aucggcaaaa agcggcgcgc cacaagauuu ugggaccccc ggcgcgggac gccuuga         177


<210>  3618
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TF2AA__Homo_sapiens__P52655

<400>  3618

Met Ala Asn Ser Ala Asn Thr Asn Thr Val Pro Lys Leu Tyr Arg Ser 
1               5                   10                  15      


Val Ile Glu Asp Val Ile Asn Asp Val Arg Asp Ile Phe Leu Asp Asp 
            20                  25                  30          


Gly Val Asp Glu Gln Val Leu Met Glu Leu Lys Thr Leu Trp Glu Asn 
        35                  40                  45              


Lys Leu Met Gln Ser Arg Ala Val Asp Gly Phe His Ser Glu Glu Gln 
    50                  55                  60                  


Gln Leu Leu Leu Gln Val Gln Gln Gln His Gln Pro Gln Gln Gln Gln 
65                  70                  75                  80  


His His His His His His His Gln Gln Ala Gln Pro Gln Gln Thr Val 
                85                  90                  95      


Pro Gln Gln Ala Gln Thr Gln Gln Val Leu Ile Pro Ala Ser Gln Gln 
            100                 105                 110         


Ala Thr Ala Pro Gln Val Ile Val Pro Asp Ser Lys Leu Ile Gln His 
        115                 120                 125             


Met Asn Ala Ser Asn Met Ser Ala Ala Ala Thr Ala Ala Thr Leu Ala 
    130                 135                 140                 


Leu Pro Ala Gly Val Thr Pro Val Gln Gln Ile Leu Thr Asn Ser Gly 
145                 150                 155                 160 


Gln Leu Leu Gln Val Val Arg Ala Ala Asn Gly Ala Gln Tyr Ile Phe 
                165                 170                 175     


Gln Pro Gln Gln Ser Val Val Leu Gln Gln Gln Val Ile Pro Gln Met 
            180                 185                 190         


Gln Pro Gly Gly Val Gln Ala Pro Val Ile Gln Gln Val Leu Ala Pro 
        195                 200                 205             


Leu Pro Gly Gly Ile Ser Pro Gln Thr Gly Val Ile Ile Gln Pro Gln 
    210                 215                 220                 


Gln Ile Leu Phe Thr Gly Asn Lys Thr Gln Val Ile Pro Thr Thr Val 
225                 230                 235                 240 


Ala Ala Pro Thr Pro Ala Gln Ala Gln Ile Thr Ala Thr Gly Gln Gln 
                245                 250                 255     


Gln Pro Gln Ala Gln Pro Ala Gln Thr Gln Ala Pro Leu Val Leu Gln 
            260                 265                 270         


Val Asp Gly Thr Gly Asp Thr Ser Ser Glu Glu Asp Glu Asp Glu Glu 
        275                 280                 285             


Glu Asp Tyr Asp Asp Asp Glu Glu Glu Asp Lys Glu Lys Asp Gly Ala 
    290                 295                 300                 


Glu Asp Gly Gln Val Glu Glu Glu Pro Leu Asn Ser Glu Asp Asp Val 
305                 310                 315                 320 


Ser Asp Glu Glu Gly Gln Glu Leu Phe Asp Thr Glu Asn Val Val Val 
                325                 330                 335     


Cys Gln Tyr Asp Lys Ile His Arg Ser Lys Asn Lys Trp Lys Phe His 
            340                 345                 350         


Leu Lys Asp Gly Ile Met Asn Leu Asn Gly Arg Asp Tyr Ile Phe Ser 
        355                 360                 365             


Lys Ala Ile Gly Asp Ala Glu Trp 
    370                 375     


<210>  3619
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TF2AA__Homo_sapiens__AAF26776

<400>  3619
auggcgaacu cggcaaauac aaacaccgug ccuaaauuau acagaucugu gauugaagau       60

gucauuaaug augugagaga caucuuucug gaugauggag uggaugaaca aguacugaug      120

gaacuaaaaa cuuuauggga aaacaaacua augcagucca gggcaguaga uggauuucau      180

ucagaagagc agcagcuucu acugcaaguu caacagcagc aucaacccca gcagcagcag      240

caucaccacc aucaccauca ucagcaagcu cagccucagc agacaguacc ucagcaagcg      300

cagacccagc agguucuuau uccugcauca cagcaagcca cagcaccaca aguuauuguu      360

ccagauucua aguugauaca gcauaugaau gcaucaaaca ugagugcugc ugcuacagcu      420

gcuaccuuag cacucccugc aggugugacu ccuguucagc agauauuaac aaauucaggc      480

cagcuucuuc agguggucag agcagccaau ggugcccaau auaucuuuca gccucagcag      540

ucagugguuc uacaacaaca gguuauacca caaaugcagc cugguggagu acaagcuccu      600

guuauacagc aggugcuggc uccucuuccu ggagggauuu caccacagac aggugucauc      660

auccagccuc agcaaaucuu auuuacagga aauaagacuc aaguuauacc uacgacagug      720

gcagcaccua caccagccca agcacagaua acugcaacug gccagcagca accgcaggcc      780

cagccugcuc aaacacaagc uccauugguc uuacaaguug auggaacugg ggauacauca      840

ucugaagaag augaagauga agaagaagac uaugaugaug augaggagga agacaaagag      900

aaagauggag cugaagaugg gcagguggaa gaagagcccc ucaauaguga agaugaugug      960

agugaugagg aaggacagga acucuuugac acagaaaaug uuguuguaug ccaauaugau     1020

aagauacaca gaaguaaaaa caaauggaaa uuucaucuca aggauggcau uaugaaucuu     1080

aauggaagag auuauauauu uuccaaagcc auuggagaug cagaauggug a              1131


<210>  3620
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TF2AA__Homo_sapiens__AAF26776

<400>  3620
auggccaaca gcgccaacac caacaccgug cccaagcugu accgcuccgu caucgaggac       60

gugaucaacg acgugcggga caucuuccuc gacgacggcg ucgacgagca gguccugaug      120

gagcugaaga cgcucuggga gaacaagcug augcagagcc gcgcggugga cggguuccac      180

uccgaggagc agcagcugcu ccuccaggug cagcagcagc accagccgca gcagcagcag      240

caccaccacc accaccacca ccagcaggcc cagccccagc agaccgugcc ccagcaggcc      300

cagacccagc agguccugau ccccgccagc cagcaggcca ccgcgcccca ggugaucgug      360

ccggacucca agcugaucca gcacaugaac gccagcaaca uguccgccgc cgcgacggcc      420

gccacccugg cccugcccgc cggcgugacc cccguccagc agauccucac caacagcggg      480

cagcugcucc agguggugcg ggcggccaac ggcgcccagu acaucuucca gccgcagcag      540

uccgucgugc ugcagcagca ggucaucccc cagaugcagc ccgggggcgu gcaggccccc      600

gugauccagc agguccuggc cccgcugccc ggcgggauca gcccccagac gggcgugauc      660

auccagcccc agcagauccu cuucaccggg aacaagaccc aggugauccc gaccacggug      720

gcggccccca cccccgccca ggcccagauc accgccaccg gccagcagca gccccaggcg      780

cagccggccc agacgcaggc gccccugguc cuccaggugg acgggaccgg cgacaccucc      840

agcgaggagg acgaggacga ggaggaggac uacgacgacg acgaggagga ggacaaggag      900

aaggacggcg ccgaggacgg gcaggucgag gaggagcccc ugaacuccga ggacgacgug      960

agcgacgagg agggccagga gcuguucgac accgagaacg uggucgugug ccaguacgac     1020

aagauccacc gcuccaagaa caaguggaag uuccaccuga aggacgggau caugaaccuc     1080

aacggccggg acuacaucuu cagcaaggcc aucggcgacg ccgaguggug a              1131


<210>  3621
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TF2AA__Homo_sapiens__AAF26776

<400>  3621
auggccaacu ccgccaacac caacaccguc cccaagcucu accgcuccgu caucgaggac       60

gucaucaacg acguccgcga caucuuccuc gacgacggcg ucgacgagca gguccucaug      120

gagcucaaga cccucuggga gaacaagcuc augcaguccc gcgccgucga cggcuuccac      180

uccgaggagc agcagcuccu ccuccagguc cagcagcagc accagcccca gcagcagcag      240

caccaccacc accaccacca ccagcaggcc cagccccagc agaccguccc ccagcaggcc      300

cagacccagc agguccucau ccccgccucc cagcaggcca ccgcccccca ggucaucguc      360

cccgacucca agcucaucca gcacaugaac gccuccaaca uguccgccgc cgccaccgcc      420

gccacccucg cccuccccgc cggcgucacc cccguccagc agauccucac caacuccggc      480

cagcuccucc aggucguccg cgccgccaac ggcgcccagu acaucuucca gccccagcag      540

uccgucgucc uccagcagca ggucaucccc cagaugcagc ccggcggcgu ccaggccccc      600

gucauccagc agguccucgc cccccucccc ggcggcaucu ccccccagac cggcgucauc      660

auccagcccc agcagauccu cuucaccggc aacaagaccc aggucauccc caccaccguc      720

gccgccccca cccccgccca ggcccagauc accgccaccg gccagcagca gccccaggcc      780

cagcccgccc agacccaggc cccccucguc cuccaggucg acggcaccgg cgacaccucc      840

uccgaggagg acgaggacga ggaggaggac uacgacgacg acgaggagga ggacaaggag      900

aaggacggcg ccgaggacgg ccaggucgag gaggagcccc ucaacuccga ggacgacguc      960

uccgacgagg agggccagga gcucuucgac accgagaacg ucgucgucug ccaguacgac     1020

aagauccacc gcuccaagaa caaguggaag uuccaccuca aggacggcau caugaaccuc     1080

aacggccgcg acuacaucuu cuccaaggcc aucggcgacg ccgaguggug a              1131


<210>  3622
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TF2AA__Homo_sapiens__AAF26776

<400>  3622
auggccaaca gcgcuaauac caacacagug cccaagcugu acagauccgu caucgaggac       60

guuauuaaug augugaggga cauauuccuc gaugacggcg uagaugaaca ggugcuuaug      120

gagcugaaaa cuuuguggga aaacaaguua augcaaucuc gggcagucga cggguuucac      180

ucagaggaac agcagcugcu acuccaggug caacagcagc aucagccuca acagcagcag      240

caccaucacc aucaccacca ucaacaggcc cagccacaac agacgguucc gcagcaggcg      300

caaacccaac aggugcugau ccccgcuagu cagcaggcca cagcaccuca ggucauugug      360

ccagauagca aacuuaucca gcacaugaau gccuccaaca ugucugcugc agccacugcu      420

gccacccugg cguugcccgc aggaguaaca ccuguucagc aaauucucac caauucgggu      480

cagcugcucc aggugguccg cgccgcuaac ggcgcccagu auaucuucca accacagcag      540

ucaguggugc uccaacagca ggucauaccc cagaugcaac cugggggagu ucaggcacca      600

gugauccagc agguauuagc uccgcugccc ggcgguauua gcccucaaac uggggugauc      660

auucagccac agcagauccu uuuuacagga aauaagaccc aagucauacc cacgacugug      720

gccgcgccua ccccagccca ggcacagauu acagcuacug gccaacagca gccccaggcc      780

caaccggcuc agacccaggc cccuuugguu cuacaggugg acggcacagg ggauaccagu      840

uccgaggagg acgaagauga ggaagaggac uacgaugacg acgaggaaga ggauaaagaa      900

aaggacggag cagaggaugg ucaagucgaa gaggagcccc ugaacucuga agacgaugug      960

agcgacgagg aaggccagga gcuguucgau acggaaaaug uaguugugug ccaguaugac     1020

aagauccauc gauccaaaaa caaguggaaa uuucaccuga aggaugggau uaugaaucuu     1080

aacggacgug acuacaucuu cucaaaagcc aucggcgaug cugaguggug a              1131


<210>  3623
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TF2AA__Homo_sapiens__AAF26776

<400>  3623
auggccaaca gcgccaacac caacaccgug cccaagcugu acagaagcgu gaucgaggac       60

gugaucaacg acgugagaga caucuuccug gacgacggcg uggacgagca ggugcugaug      120

gagcugaaga cccuguggga gaacaagcug augcagagca gagccgugga cggcuuccac      180

agcgaggagc agcagcugcu gcugcaggug cagcagcagc accagcccca gcagcagcag      240

caccaccacc accaccacca ccagcaggcc cagccccagc agaccgugcc ccagcaggcc      300

cagacccagc aggugcugau ccccgccagc cagcaggcca ccgcccccca ggugaucgug      360

cccgacagca agcugaucca gcacaugaac gccagcaaca ugagcgccgc cgccaccgcc      420

gccacccugg cccugcccgc cggcgugacc cccgugcagc agauccugac caacagcggc      480

cagcugcugc agguggugag agccgccaac ggcgcccagu acaucuucca gccccagcag      540

agcguggugc ugcagcagca ggugaucccc cagaugcagc ccggcggcgu gcaggccccc      600

gugauccagc aggugcuggc cccccugccc ggcggcauca gcccccagac cggcgugauc      660

auccagcccc agcagauccu guucaccggc aacaagaccc aggugauccc caccaccgug      720

gccgccccca cccccgccca ggcccagauc accgccaccg gccagcagca gccccaggcc      780

cagcccgccc agacccaggc cccccuggug cugcaggugg acggcaccgg cgacaccagc      840

agcgaggagg acgaggacga ggaggaggac uacgacgacg acgaggagga ggacaaggag      900

aaggacggcg ccgaggacgg ccagguggag gaggagcccc ugaacagcga ggacgacgug      960

agcgacgagg agggccagga gcuguucgac accgagaacg ugguggugug ccaguacgac     1020

aagauccaca gaagcaagaa caaguggaag uuccaccuga aggacggcau caugaaccug     1080

aacggcagag acuacaucuu cagcaaggcc aucggcgacg ccgaguggug a              1131


<210>  3624
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TF2AA__Homo_sapiens__AAF26776

<400>  3624
auggccaaca gcgcuaauac caacacagug cccaagcugu acagauccgu caucgaggac       60

guuauuaaug augugcggga caucuuccuc gaugacggcg uggaugaaca gguccugaug      120

gagcuuaaaa cgcuguggga aaacaagcuc augcaaucuc gcgccgugga cggguuucac      180

agcgaggaac agcagcugcu ucugcagguu caacagcagc aucagccuca acagcagcag      240

caccaucacc aucaccacca ucaacaggcg cagccgcaac agaccgugcc ccagcaggcu      300

caaacacagc agguccucau uccugccucc cagcaagcca ccgcucccca ggugaucguu      360

ccugauucua aacugauuca gcacaugaau gccagcaaca uguccgcugc cgcgacagcc      420

gcuacccugg cccuccccgc uggagugaca ccuguccagc aaauccugac caauucuggc      480

cagcuucucc agguggugag agccgcgaac ggggcccagu auaucuucca accgcagcag      540

agcgucguuc uccaacaaca ggugauuccc cagaugcagc cuggaggcgu gcaggcuccc      600

gucauccaac aggugcuggc cccucuuccc gggggaauuu ccccgcagac gggcguuauc      660

auucagccuc agcagauccu guuuaccggc aauaagacac aagugauucc caccacaguc      720

gcugccccua cccccgccca ggcucagauc acggcgacag ggcaacagca gccccaggcc      780

caaccugcuc agacccaggc cccgcucgug cugcagguug acggaacagg cgauaccagc      840

ucugaggagg acgaagauga ggaagaggac uacgaugacg acgaggaaga ggauaaagaa      900

aaggacgggg ccgaggaugg acaaguggaa gaggagcccc ugaacuccga agacgauguc      960

agcgacgagg aaggccagga gcuguucgau accgaaaaug uggucgugug ccaguaugac     1020

aagauccauc ggucuaaaaa caaguggaaa uuucaccuga aggaugggau uaugaaucuu     1080

aacggacgcg acuacaucuu cuccaaagcu auuggcgaug ccgaguggug a              1131


<210>  3625
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFR2__Homo_sapiens__P37173

<400>  3625

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  3626
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFR2__Homo_sapiens__AAT70724

<400>  3626
augggucggg ggcugcucag gggccugugg ccgcugcaca ucguccugug gacgcguauc       60

gccagcacga ucccaccgca cguucagaag ucgguuaaua acgacaugau agucacugac      120

aacaacggug cagucaaguu uccacaacug uguaaauuuu gugaugugag auuuuccacc      180

ugugacaacc agaaauccug caugagcaac ugcagcauca ccuccaucug ugagaagcca      240

caggaagucu guguggcugu auggagaaag aaugacgaga acauaacacu agagacaguu      300

ugccaugacc ccaagcuccc cuaccaugac uuuauucugg aagaugcugc uucuccaaag      360

ugcauuauga aggaaaaaaa aaagccuggu gagacuuucu ucauguguuc cuguagcucu      420

gaugagugca augacaacau caucuucuca gaagaauaua acaccagcaa uccugacuug      480

uugcuaguca uauuucaagu gacaggcauc agccuccugc caccacuggg aguugccaua      540

ucugucauca ucaucuucua cugcuaccgc guuaaccggc agcagaagcu gaguucaacc      600

ugggaaaccg gcaagacgcg gaagcucaug gaguucagcg agcacugugc caucauccug      660

gaagaugacc gcucugacau cagcuccacg ugugccaaca acaucaacca caacacagag      720

cugcugccca uugagcugga cacccuggug gggaaagguc gcuuugcuga ggucuauaag      780

gccaagcuga agcagaacac uucagagcag uuugagacag uggcagucaa gaucuuuccc      840

uaugaggagu augccucuug gaagacagag aaggacaucu ucucagacau caaucugaag      900

caugagaaca uacuccaguu ccugacggcu gaggagcgga agacggaguu ggggaaacaa      960

uacuggcuga ucaccgccuu ccacgccaag ggcaaccuac aggaguaccu gacgcggcau     1020

gucaucagcu gggaggaccu gcgcaagcug ggcagcuccc ucgcccgggg gauugcucac     1080

cuccacagug aucacacucc augugggagg cccaagaugc ccaucgugca cagggaccuc     1140

aagagcucca auauccucgu gaagaacgac cuaaccugcu gccuguguga cuuugggcuu     1200

ucccugcguc uggacccuac ucugucugug gaugaccugg cuaacagugg gcagguggga     1260

acugcaagau acauggcucc agaaguccua gaauccagga ugaauuugga gaauguugag     1320

uccuucaagc agaccgaugu cuacuccaug gcucuggugc ucugggaaau gacaucucgc     1380

uguaaugcag ugggagaagu aaaagauuau gagccuccau uugguuccaa ggugcgggag     1440

caccccugug ucgaaagcau gaaggacaac guguugagag aucgagggcg accagaaauu     1500

cccagcuucu ggcucaacca ccagggcauc cagauggugu gugagacguu gacugagugc     1560

ugggaccacg acccagaggc ccgucucaca gcccagugug uggcagaacg cuucagugag     1620

cuggagcauc uggacaggcu cucggggagg agcugcucgg aggagaagau uccugaagac     1680

ggcucccuaa acacuaccaa auag                                            1704


<210>  3627
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFR2__Homo_sapiens__AAT70724

<400>  3627
augggccgcg ggcugcuccg gggccugugg ccccugcaca ucgugcucug gacccgcauc       60

gccagcacca ucccgcccca cguccagaag uccgugaaca acgacaugau cgugacggac      120

aacaacgggg ccgucaaguu cccccagcug ugcaaguucu gcgacgugcg guucagcacg      180

ugcgacaacc agaaguccug caugagcaac ugcuccauca ccagcaucug cgagaagccc      240

caggaggugu gcgucgcggu guggcgcaag aacgacgaga acaucacccu ggagaccgug      300

ugccacgacc cgaagcuccc cuaccacgac uucauccugg aggacgccgc cucccccaag      360

ugcaucauga aggagaagaa gaagcccggc gagaccuucu ucaugugcag cugcuccagc      420

gacgagugca acgacaacau caucuucucc gaggaguaca acaccagcaa cccggaccug      480

cuccugguca ucuuccaggu gaccgggauc ucccugcucc cgccccuggg cguggccauc      540

agcgucauca ucaucuucua cugcuaccgg gugaaccgcc agcagaagcu guccagcacg      600

ugggagaccg gcaagacccg gaagcucaug gaguucuccg agcacugcgc caucauccug      660

gaggacgacc gcagcgacau cuccagcacg ugcgcgaaca acaucaacca caacaccgag      720

cugcucccca ucgagcugga cacccuggug gggaagggcc gguucgccga ggucuacaag      780

gccaagcuca agcagaacac cagcgagcag uucgagaccg uggccgugaa gaucuucccc      840

uacgaggagu acgcguccug gaagacggag aaggacaucu ucagcgacau caaccugaag      900

cacgagaaca uccugcaguu ccucaccgcc gaggagcgca agaccgagcu ggggaagcag      960

uacuggcuga ucaccgccuu ccacgccaag ggcaaccucc aggaguaccu gacgcggcac     1020

gucaucuccu gggaggaccu gcgcaagcuc gggagcuccc uggcccgggg caucgcgcac     1080

cuccacagcg accacacccc cugcggccgc cccaagaugc ccaucgugca ccgggaccug     1140

aaguccagca acauccuggu gaagaacgac cugaccugcu gccucugcga cuucgggcug     1200

ucccugcgcc ucgacccgac ccugagcguc gacgaccugg ccaacuccgg ccaggugggg     1260

acggcccggu acauggcccc cgaggugcuc gagagccgca ugaaccugga gaacgucgag     1320

uccuucaagc agaccgacgu guacagcaug gcccuggucc ucugggagau gaccucccgg     1380

ugcaacgcgg ugggcgaggu gaaggacuac gagccgcccu ucggcagcaa gguccgcgag     1440

caccccugcg uggaguccau gaaggacaac gugcugcggg accgcgggcg ccccgagauc     1500

cccagcuucu ggcugaacca ccagggcauc cagauggucu gcgagacccu cacggagugc     1560

ugggaccacg accccgaggc ccggcugacc gcccagugcg uggccgagcg cuucuccgag     1620

cuggagcacc uggaccggcu cagcgggcgc agcugcuccg aggagaagau cccggaggac     1680

ggcagccuga acaccaccaa guga                                            1704


<210>  3628
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFR2__Homo_sapiens__AAT70724

<400>  3628
augggccgcg gccuccuccg cggccucugg ccccuccaca ucguccucug gacccgcauc       60

gccuccacca ucccccccca cguccagaag uccgucaaca acgacaugau cgucaccgac      120

aacaacggcg ccgucaaguu cccccagcuc ugcaaguucu gcgacguccg cuucuccacc      180

ugcgacaacc agaaguccug cauguccaac ugcuccauca ccuccaucug cgagaagccc      240

caggaggucu gcgucgccgu cuggcgcaag aacgacgaga acaucacccu cgagaccguc      300

ugccacgacc ccaagcuccc cuaccacgac uucauccucg aggacgccgc cucccccaag      360

ugcaucauga aggagaagaa gaagcccggc gagaccuucu ucaugugcuc cugcuccucc      420

gacgagugca acgacaacau caucuucucc gaggaguaca acaccuccaa ccccgaccuc      480

cuccucguca ucuuccaggu caccggcauc ucccuccucc ccccccucgg cgucgccauc      540

uccgucauca ucaucuucua cugcuaccgc gucaaccgcc agcagaagcu cuccuccacc      600

ugggagaccg gcaagacccg caagcucaug gaguucuccg agcacugcgc caucauccuc      660

gaggacgacc gcuccgacau cuccuccacc ugcgccaaca acaucaacca caacaccgag      720

cuccucccca ucgagcucga cacccucguc ggcaagggcc gcuucgccga ggucuacaag      780

gccaagcuca agcagaacac cuccgagcag uucgagaccg ucgccgucaa gaucuucccc      840

uacgaggagu acgccuccug gaagaccgag aaggacaucu ucuccgacau caaccucaag      900

cacgagaaca uccuccaguu ccucaccgcc gaggagcgca agaccgagcu cggcaagcag      960

uacuggcuca ucaccgccuu ccacgccaag ggcaaccucc aggaguaccu cacccgccac     1020

gucaucuccu gggaggaccu ccgcaagcuc ggcuccuccc ucgcccgcgg caucgcccac     1080

cuccacuccg accacacccc cugcggccgc cccaagaugc ccaucgucca ccgcgaccuc     1140

aaguccucca acauccucgu caagaacgac cucaccugcu gccucugcga cuucggccuc     1200

ucccuccgcc ucgaccccac ccucuccguc gacgaccucg ccaacuccgg ccaggucggc     1260

accgcccgcu acauggcccc cgagguccuc gagucccgca ugaaccucga gaacgucgag     1320

uccuucaagc agaccgacgu cuacuccaug gcccucgucc ucugggagau gaccucccgc     1380

ugcaacgccg ucggcgaggu caaggacuac gagccccccu ucggcuccaa gguccgcgag     1440

caccccugcg ucgaguccau gaaggacaac guccuccgcg accgcggccg ccccgagauc     1500

cccuccuucu ggcucaacca ccagggcauc cagauggucu gcgagacccu caccgagugc     1560

ugggaccacg accccgaggc ccgccucacc gcccagugcg ucgccgagcg cuucuccgag     1620

cucgagcacc ucgaccgccu cuccggccgc uccugcuccg aggagaagau ccccgaggac     1680

ggcucccuca acaccaccaa guga                                            1704


<210>  3629
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFR2__Homo_sapiens__AAT70724

<400>  3629
augggcagag ggcugcucag gggacuuugg ccccugcaca ucguguugug gacccggauu       60

gccagcacaa uaccuccaca uguccagaag uccguuaaca augacaugau cgugacugau      120

aacaauggug cuguaaaauu cccgcaauua ugcaaguuuu gugacgugcg cuucucuacg      180

ugcgauaacc agaaaucaug uaugaguaau ugcagcauua ccuccaucug ugagaagccc      240

caggaagucu gcguggcagu uuggcguaaa aacgacgaga auauuacacu ggaaacugug      300

ugucacgauc cuaagcuacc auaccaugac uuuauccucg aggaugccgc gucucccaag      360

ugcauaauga aagaaaagaa aaagccuggc gagaccuucu uuauguguuc gugcucaagc      420

gacgagugua acgauaauau cauuuucagu gaagaguaua acacauccaa uccagaccug      480

cuucugguca ucuuucaggu gaccgggauu ucuuugcugc ccccucucgg aguagcuauc      540

agcguuauaa uuaucuucua cugcuaucga gugaacagac aacagaaacu guccucaacu      600

ugggaaacag gcaagaccag gaagcucaug gaguuuagug agcacugcgc cauuaucuua      660

gaagaugacc ggagcgauau cucuuccacg ugugcaaaua acauuaauca uaacacugag      720

cugcuuccaa uagaauugga cacccugguc gguaaagggc gcuucgccga gguguacaag      780

gcuaaacuaa agcagaacac aucagaacag uuugagacug uggcagucaa aaucuucccg      840

uaugaggaau acgccagcug gaagaccgag aaagacauuu uuagugauau caaucucaag      900

cacgaaaaca uacugcaauu ccuuacagcu gaggaaagaa agaccgagcu gggaaaacag      960

uauugguuga uuacggccuu ccacgcgaag ggcaaucucc aggaguaccu gacuaggcau     1020

guuaucucuu gggaagacuu acggaaacug ggcuccagcc ucgcacgcgg gaucgcccac     1080

cuucauucgg aucacacacc cugcggacga ccuaagaugc caauugugca cagagaccug     1140

aaaucuucca acaucuuggu aaagaaugau cuaaccuguu gccuguguga cuuuggucuc     1200

ucacugaggc uugaucccac ucugagugug gacgauuugg cuaacagcgg ccaggucggg     1260

acagcccggu acauggcacc ugaggugcuc gaaucccgua ugaaucugga gaacguugaa     1320

ucuuucaagc aaaccgacgu guauagcaug gcuuuagucc ugugggagau gacgucacgc     1380

ugcaaugccg ugggagaggu aaaagauuac gaaccacccu uuggcaguaa gguuagagag     1440

cauccgugug uggaauccau gaaagacaac guccuaaggg accggggucg accugagauu     1500

cccagcuucu ggcucaauca ccaggggaua cagauggugu gcgagacccu gacagaaugu     1560

ugggaucaug acccagaggc gcgccuuacu gcccaaugcg ucgcagaaag auuuucugag     1620

uuggaacacc uggauaggcu cucaggacgg aguuguagcg aggagaagau cccugaagac     1680

ggcucccuga acaccacaaa auga                                            1704


<210>  3630
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFR2__Homo_sapiens__AAT70724

<400>  3630
augggcagag gccugcugag aggccugugg ccccugcaca ucgugcugug gaccagaauc       60

gccagcacca ucccccccca cgugcagaag agcgugaaca acgacaugau cgugaccgac      120

aacaacggcg ccgugaaguu cccccagcug ugcaaguucu gcgacgugag auucagcacc      180

ugcgacaacc agaagagcug caugagcaac ugcagcauca ccagcaucug cgagaagccc      240

caggaggugu gcguggccgu guggagaaag aacgacgaga acaucacccu ggagaccgug      300

ugccacgacc ccaagcugcc cuaccacgac uucauccugg aggacgccgc cagccccaag      360

ugcaucauga aggagaagaa gaagcccggc gagaccuucu ucaugugcag cugcagcagc      420

gacgagugca acgacaacau caucuucagc gaggaguaca acaccagcaa ccccgaccug      480

cugcugguga ucuuccaggu gaccggcauc agccugcugc ccccccuggg cguggccauc      540

agcgugauca ucaucuucua cugcuacaga gugaacagac agcagaagcu gagcagcacc      600

ugggagaccg gcaagaccag aaagcugaug gaguucagcg agcacugcgc caucauccug      660

gaggacgaca gaagcgacau cagcagcacc ugcgccaaca acaucaacca caacaccgag      720

cugcugccca ucgagcugga cacccuggug ggcaagggca gauucgccga gguguacaag      780

gccaagcuga agcagaacac cagcgagcag uucgagaccg uggccgugaa gaucuucccc      840

uacgaggagu acgccagcug gaagaccgag aaggacaucu ucagcgacau caaccugaag      900

cacgagaaca uccugcaguu ccugaccgcc gaggagagaa agaccgagcu gggcaagcag      960

uacuggcuga ucaccgccuu ccacgccaag ggcaaccugc aggaguaccu gaccagacac     1020

gugaucagcu gggaggaccu gagaaagcug ggcagcagcc uggccagagg caucgcccac     1080

cugcacagcg accacacccc cugcggcaga cccaagaugc ccaucgugca cagagaccug     1140

aagagcagca acauccuggu gaagaacgac cugaccugcu gccugugcga cuucggccug     1200

agccugagac uggaccccac ccugagcgug gacgaccugg ccaacagcgg ccaggugggc     1260

accgccagau acauggcccc cgaggugcug gagagcagaa ugaaccugga gaacguggag     1320

agcuucaagc agaccgacgu guacagcaug gcccuggugc ugugggagau gaccagcaga     1380

ugcaacgccg ugggcgaggu gaaggacuac gagccccccu ucggcagcaa ggugagagag     1440

caccccugcg uggagagcau gaaggacaac gugcugagag acagaggcag acccgagauc     1500

cccagcuucu ggcugaacca ccagggcauc cagauggugu gcgagacccu gaccgagugc     1560

ugggaccacg accccgaggc cagacugacc gcccagugcg uggccgagag auucagcgag     1620

cuggagcacc uggacagacu gagcggcaga agcugcagcg aggagaagau ccccgaggac     1680

ggcagccuga acaccaccaa guga                                            1704


<210>  3631
<211>  1704
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFR2__Homo_sapiens__AAT70724

<400>  3631
augggcagag ggcugcuccg gggacugugg ccccuucaca ucgugcugug gacccgcauu       60

gccagcacaa ucccuccgca uguccagaag uccguuaaca augacaugau ugugacggau      120

aacaauggcg cugugaaauu cccccaacuc ugcaaguuuu gugacgucag auucucuacc      180

ugcgauaacc agaaaagcug uauguccaau ugcucuauca caagcauuug ugagaagccu      240

caggaagugu gcguugccgu guggcggaaa aacgacgaga auaucacccu ggaaacaguc      300

ugucacgauc ccaagcugcc uuaccaugac uuuauccugg aggaugcggc uucccccaag      360

ugcauuauga aagaaaagaa aaagccuggg gagaccuucu uuauguguuc uugcagcucc      420

gacgagugua acgauaauau cauuuucagc gaagaguaua acacaucuaa uccggaccuc      480

cugcugguga ucuuucaggu uaccggaauu ucccuccugc ccccucuugg cguggccauc      540

agcgucauua ucaucuucua cugcuaucgc gugaacagac aacagaaacu gucuuccacg      600

ugggaaaccg ggaagacacg gaagcucaug gaguuuagcg agcacugcgc cauuauccug      660

gaagaugacc gcucugauau uuccagcacc ugugcuaaua acaucaauca uaacacagag      720

cuucugccca uugaacucga cacccuggug ggaaaaggca gauucgccga ggucuacaag      780

gcuaaacuga agcagaacac guccgaacag uuugagacag uugccgugaa aaucuucccu      840

uaugaggaau acgcgucuug gaagaccgag aaagacaucu uuagcgauau uaaucucaag      900

cacgaaaaca uccugcaauu ccuuacagcc gaggaacgga agaccgagcu gggcaaacag      960

uauuggcuca uuaccgcuuu ccacgccaag gggaaucugc aggaguaccu uacacgccau     1020

gugaucuccu gggaagaccu gagaaaacuc ggaagcucuc uggcucgggg cauugcccac     1080

cuucauuccg aucacacgcc cugcgggcgc ccgaagaugc cuaucgucca cagagaccuc     1140

aaaagcucua acauccuggu gaagaaugau cuuaccuguu gccuguguga cuuuggacuc     1200

agccugcggc uugaucccac acuguccguu gacgaucucg cgaacucugg ccaggugggg     1260

accgcccgcu acauggcucc ugagguccug gaaagcagaa ugaaucugga gaacguggaa     1320

uccuucaagc aaacagacgu uuauagcaug gcccucgugc ugugggagau gaccucucgg     1380

ugcaaugcug ucggagaggu gaaagauuac gaaccucccu uuggcuccaa ggucagagag     1440

caucccugug uggaaagcau gaaagacaac guucuucgcg accggggcag accggagauu     1500

cccucuuucu ggcugaauca ccaggggauc cagauggugu gcgagacgcu cacagaaugu     1560

ugggaucaug acccugaggc ccgccugacc gcccaaugcg ucgcugaacg guuuuccgag     1620

cuggaacacc uugauagacu cagcggacgc uccuguucug aggagaagau ucccgaagac     1680

ggcagccuga acaccacaaa auga                                            1704


<210>  3632
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGM-4__Homo_sapiens__B2R7D1

<400>  3632

Met Met Asp Ala Ser Lys Glu Leu Gln Val Leu His Ile Asp Phe Leu 
1               5                   10                  15      


Asn Gln Asp Asn Ala Val Ser His His Thr Trp Glu Phe Gln Thr Ser 
            20                  25                  30          


Ser Pro Val Phe Arg Arg Gly Gln Val Phe His Leu Arg Leu Val Leu 
        35                  40                  45              


Asn Gln Pro Pro Gln Ser Tyr His Gln Leu Lys Leu Glu Phe Ser Thr 
    50                  55                  60                  


Gly Pro Asn Pro Ser Ile Ala Lys His Thr Leu Val Val Leu Asp Pro 
65                  70                  75                  80  


Arg Thr Pro Ser Asp His Tyr Asn Trp Gln Ala Thr Leu Gln Asn Glu 
                85                  90                  95      


Ser Gly Lys Glu Val Thr Val Ala Val Thr Ser Ser Pro Asn Ala Ile 
            100                 105                 110         


Leu Gly Lys Tyr Gln Leu Asn Val Lys Thr Gly Asn His Ile Leu Lys 
        115                 120                 125             


Ser Glu Glu Asn Ile Leu Tyr Leu Leu Phe Asn Pro Trp Cys Lys Glu 
    130                 135                 140                 


Asp Met Val Phe Met Pro Asp Glu Asp Glu Arg Lys Glu Tyr Ile Leu 
145                 150                 155                 160 


Asn Asp Thr Gly Cys His Tyr Val Gly Ala Ala Arg Ser Ile Lys Cys 
                165                 170                 175     


Lys Pro Trp Asn Phe Gly Gln Phe Glu Lys Asn Val Leu Asp Cys Cys 
            180                 185                 190         


Ile Ser Leu Leu Thr Glu Ser Ser Leu Lys Pro Thr Asp Arg Arg Asp 
        195                 200                 205             


Pro Val Leu Val Cys Arg Ala Met Cys Ala Met Met Ser Phe Glu Lys 
    210                 215                 220                 


Gly Gln Gly Val Leu Ile Gly Asn Trp Thr Gly Asp Tyr Glu Gly Gly 
225                 230                 235                 240 


Thr Ala Pro Tyr Lys Trp Thr Gly Ser Ala Pro Ile Leu Gln Gln Tyr 
                245                 250                 255     


Tyr Asn Thr Lys Gln Ala Val Cys Phe Gly Gln Cys Trp Val Phe Ala 
            260                 265                 270         


Gly Ile Leu Thr Thr Val Leu Arg Ala Leu Gly Ile Pro Ala Arg Ser 
        275                 280                 285             


Val Thr Gly Phe Asp Ser Ala His Asp Thr Glu Arg Asn Leu Thr Val 
    290                 295                 300                 


Asp Thr Tyr Val Asn Glu Asn Gly Glu Lys Ile Thr Ser Met Thr His 
305                 310                 315                 320 


Asp Ser Val Trp Asn Phe His Val Trp Thr Asp Ala Trp Met Lys Arg 
                325                 330                 335     


Pro Asp Leu Pro Lys Gly Tyr Asp Gly Trp Gln Ala Val Asp Ala Thr 
            340                 345                 350         


Pro Gln Glu Arg Ser Gln Gly Val Phe Cys Cys Gly Pro Ser Pro Leu 
        355                 360                 365             


Thr Ala Ile Arg Lys Gly Asp Ile Phe Ile Val Tyr Asp Thr Arg Phe 
    370                 375                 380                 


Val Phe Ser Glu Val Asn Gly Asp Arg Leu Ile Trp Leu Val Lys Met 
385                 390                 395                 400 


Val Asn Gly Gln Glu Glu Leu His Val Ile Ser Met Glu Thr Thr Ser 
                405                 410                 415     


Ile Gly Lys Asn Ile Ser Thr Lys Ala Val Gly Gln Asp Arg Arg Arg 
            420                 425                 430         


Asp Ile Thr Tyr Glu Tyr Lys Tyr Pro Glu Gly Ser Ser Glu Glu Arg 
        435                 440                 445             


Gln Val Met Asp His Ala Phe Leu Leu Leu Ser Ser Glu Arg Glu His 
    450                 455                 460                 


Arg Arg Pro Val Lys Glu Asn Phe Leu His Met Ser Val Gln Ser Asp 
465                 470                 475                 480 


Asp Val Leu Leu Gly Asn Ser Val Asn Phe Thr Val Ile Leu Lys Arg 
                485                 490                 495     


Lys Thr Ala Ala Leu Gln Asn Val Asn Ile Leu Gly Ser Phe Glu Leu 
            500                 505                 510         


Gln Leu Tyr Thr Gly Lys Lys Met Ala Lys Leu Cys Asp Leu Asn Lys 
        515                 520                 525             


Thr Ser Gln Ile Gln Gly Gln Val Ser Glu Val Thr Leu Thr Leu Asp 
    530                 535                 540                 


Ser Lys Thr Tyr Ile Asn Ser Leu Ala Ile Leu Asp Asp Glu Pro Val 
545                 550                 555                 560 


Ile Arg Gly Phe Ile Ile Ala Glu Ile Val Glu Ser Lys Glu Ile Met 
                565                 570                 575     


Ala Ser Glu Val Phe Thr Ser Phe Gln Tyr Pro Glu Phe Ser Ile Glu 
            580                 585                 590         


Leu Pro Asn Thr Gly Arg Ile Gly Gln Leu Leu Val Cys Asn Cys Ile 
        595                 600                 605             


Phe Lys Asn Thr Leu Ala Ile Pro Leu Thr Asp Val Lys Phe Ser Leu 
    610                 615                 620                 


Glu Ser Leu Gly Ile Ser Ser Leu Gln Thr Ser Asp His Gly Thr Val 
625                 630                 635                 640 


Gln Pro Gly Glu Thr Ile Gln Ser Gln Ile Lys Cys Thr Pro Ile Lys 
                645                 650                 655     


Thr Gly Pro Lys Lys Phe Ile Val Lys Leu Ser Ser Lys Gln Val Lys 
            660                 665                 670         


Glu Ile Asn Ala Gln Lys Ile Val Leu Ile Thr Lys 
        675                 680                 


<210>  3633
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGM-4__Homo_sapiens__BAG35778

<400>  3633
augauggaug caucaaaaga gcugcaaguu cuccacauug acuucuugaa ucaggacaac       60

gccguuucuc accacacaug ggaguuccaa acgagcaguc cuguguuccg gcgaggacag      120

guguuucacc ugcggcuggu gcugaaccag cccccacaau ccuaccacca acugaaacug      180

gaauucagca cagggccgaa uccuagcauc gccaaacaca cccugguggu gcucgacccg      240

aggacgcccu cagaccacua caacuggcag gcaacccuuc aaaaugaguc uggcaaagag      300

gucacagugg cugucaccag uucccccaau gccauccugg gcaaguacca acuaaacgug      360

aaaacuggaa accacauccu uaagucugaa gaaaacaucc uauaccuucu cuucaaccca      420

ugguguaaag aggacauggu uuucaugccu gaugaggacg agcgcaaaga guacauccuc      480

aaugacacgg gcugccauua cgugggggcu gccagaagua ucaaaugcaa acccuggaac      540

uuuggucagu uugagaaaaa uguccuggac ugcugcauuu cccugcugac ugagagcucc      600

cucaagccca cagauaggag ggaccccgug cuggugugca gggccaugug ugcuaugaug      660

agcuuugaga aaggccaggg cgugcucauu gggaauugga cuggggacua cgaagguggc      720

acagccccau acaaguggac aggcagugcc ccgauccugc agcaguacua caacacgaag      780

caggcugugu gcuuuggcca gugcugggug uuugcuggga uccugacuac agugcugaga      840

gcguugggca ucccagcacg cagugugaca ggcuucgauu cagcucacga cacagaaagg      900

aaccucacgg uggacaccua ugugaaugag aauggcgaga aaaucaccag uaugacccac      960

gacucugucu ggaauuucca uguguggacg gaugccugga ugaagcgacc ggaucugccc     1020

aagggcuacg acggcuggca ggcuguggac gcaacgccgc aggagcgaag ccaggguguc     1080

uucugcugug ggccaucacc acugaccgcc auccgcaaag gugacaucuu uauugucuau     1140

gacaccagau ucgucuucuc agaagugaau ggugacaggc ucaucugguu ggugaagaug     1200

gugaaugggc aggaggaguu acacguaauu ucaauggaga ccacaagcau cgggaaaaac     1260

aucagcacca aggcaguggg ccaagacagg cggagagaua ucaccuauga guacaaguau     1320

ccagaaggcu ccucugagga gaggcagguc auggaucaug ccuuccuccu ucucaguucu     1380

gagagggagc acagacgacc uguaaaagag aacuuucuuc acaugucggu acaaucagau     1440

gaugugcugc ugggaaacuc uguuaauuuc accgugauuc uuaaaaggaa gaccgcugcc     1500

cuacagaaug ucaacaucuu gggcuccuuu gaacuacagu uguacacugg caagaagaug     1560

gcaaaacugu gugaccucaa uaagaccucg cagauccaag gucaaguauc agaagugacu     1620

cugaccuugg acuccaagac cuacaucaac agccuggcua uauuagauga ugagccaguu     1680

aucagagguu ucaucauugc ggaaauugug gagucuaagg aaaucauggc cucugaagua     1740

uucacgucuu uccaguaccc ugaguucucu auagaguugc cuaacacagg cagaauuggc     1800

cagcuacuug ucugcaauug uaucuucaag aauacccugg ccaucccuuu gacugacguc     1860

aaguucucuu uggaaagccu gggcaucucc ucacuacaga ccucugacca ugggacggug     1920

cagccuggug agaccaucca aucccaaaua aaaugcaccc caauaaaaac uggacccaag     1980

aaauuuaucg ucaaguuaag uuccaaacaa gugaaagaga uuaaugcuca gaagauuguu     2040

cucaucacca aguag                                                      2055


<210>  3634
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGM-4__Homo_sapiens__BAG35778

<400>  3634
augauggacg ccagcaagga gcuccaggug cuccacaucg acuuccugaa ccaggacaac       60

gccgucuccc accacaccug ggaguuccag accagcuccc ccguguuccg ccggggccag      120

guguuccacc uccgccuggu ccugaaccag ccgccccaga gcuaccacca gcugaagcuc      180

gaguucucca cggggcccaa ccccagcauc gcgaagcaca cccugguggu gcuggacccg      240

cggacccccu ccgaccacua caacuggcag gccacccucc agaacgagag cggcaaggag      300

gucacggugg ccgugaccuc cagccccaac gccauccugg ggaaguacca gcugaacguc      360

aagaccggca accacauccu caaguccgag gagaacaucc uguaccugcu guucaacccc      420

uggugcaagg aggacauggu guucaugccg gacgaggacg agcgcaagga guacauccug      480

aacgacaccg ggugccacua cgugggcgcc gcgcggagca ucaagugcaa gcccuggaac      540

uucggccagu ucgagaagaa cguccuggac ugcugcaucu cccuccugac ggagagcucc      600

cugaagccca ccgaccgccg ggaccccgug cucgugugcc gcgccaugug cgccaugaug      660

agcuucgaga aggggcaggg cguccugauc gggaacugga ccggcgacua cgagggcggg      720

accgccccgu acaaguggac gggcuccgcg cccauccugc agcaguacua caacaccaag      780

caggccgugu gcuucgggca gugcugggug uucgccggca uccucaccac cguccugcgg      840

gcccugggga uccccgcccg cagcgugacg ggcuucgacu ccgcgcacga caccgagcgg      900

aaccucaccg uggacaccua cgucaacgag aacggcgaga agaucacgag caugacccac      960

gacagcgugu ggaacuucca cguguggacc gacgccugga ugaagcgccc cgaccugccg     1020

aagggguacg acggcuggca ggccgucgac gccacgcccc aggagcgguc ccagggggug     1080

uucugcugcg gccccagccc ccugaccgcc auccgcaagg gggacaucuu caucgucuac     1140

gacacccggu ucguguucuc cgaggugaac ggcgaccgcc ucaucuggcu ggucaagaug     1200

gugaacggcc aggaggagcu gcacgugauc agcauggaga ccaccuccau cgggaagaac     1260

aucagcacga aggcggucgg ccaggaccgg cgccgggaca ucaccuacga guacaaguac     1320

ccggaggggu ccagcgagga gcgccaggug auggaccacg ccuuccuccu gcuguccagc     1380

gagcgggagc accgccgccc cgugaaggag aacuuccucc acauguccgu ccagagcgac     1440

gacgugcugc ugggcaacuc cgugaacuuc accgucaucc ucaagcggaa gaccgccgcc     1500

cugcagaacg ugaacauccu ggggagcuuc gagcuccagc uguacacggg caagaagaug     1560

gccaagcugu gcgaccucaa caagaccucc cagauccagg gccaggugag cgaggucacc     1620

cugacccugg acuccaagac guacaucaac agccucgcga uccuggacga cgagcccgug     1680

auccgcgggu ucaucaucgc cgagaucgug gaguccaagg agaucauggc cagcgagguc     1740

uucaccagcu uccaguaccc cgaguucucc aucgagcugc cgaacaccgg ccggaucggg     1800

cagcugcucg ugugcaacug caucuucaag aacacccugg ccaucccccu gaccgacgug     1860

aaguucagcc ucgagucccu gggcaucagc ucccugcaga cgagcgacca cgggaccguc     1920

cagcccggcg agaccaucca gucccagauc aagugcaccc ccaucaagac gggcccgaag     1980

aaguucaucg ugaagcucag cuccaagcag gucaaggaga ucaacgccca gaagaucgug     2040

cugaucacca aguga                                                      2055


<210>  3635
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGM-4__Homo_sapiens__BAG35778

<400>  3635
augauggacg ccuccaagga gcuccagguc cuccacaucg acuuccucaa ccaggacaac       60

gccgucuccc accacaccug ggaguuccag accuccuccc ccgucuuccg ccgcggccag      120

gucuuccacc uccgccucgu ccucaaccag cccccccagu ccuaccacca gcucaagcuc      180

gaguucucca ccggccccaa ccccuccauc gccaagcaca cccucgucgu ccucgacccc      240

cgcacccccu ccgaccacua caacuggcag gccacccucc agaacgaguc cggcaaggag      300

gucaccgucg ccgucaccuc cucccccaac gccauccucg gcaaguacca gcucaacguc      360

aagaccggca accacauccu caaguccgag gagaacaucc ucuaccuccu cuucaacccc      420

uggugcaagg aggacauggu cuucaugccc gacgaggacg agcgcaagga guacauccuc      480

aacgacaccg gcugccacua cgucggcgcc gcccgcucca ucaagugcaa gcccuggaac      540

uucggccagu ucgagaagaa cguccucgac ugcugcaucu cccuccucac cgaguccucc      600

cucaagccca ccgaccgccg cgaccccguc cucgucugcc gcgccaugug cgccaugaug      660

uccuucgaga agggccaggg cguccucauc ggcaacugga ccggcgacua cgagggcggc      720

accgcccccu acaaguggac cggcuccgcc cccauccucc agcaguacua caacaccaag      780

caggccgucu gcuucggcca gugcuggguc uucgccggca uccucaccac cguccuccgc      840

gcccucggca uccccgcccg cuccgucacc ggcuucgacu ccgcccacga caccgagcgc      900

aaccucaccg ucgacaccua cgucaacgag aacggcgaga agaucaccuc caugacccac      960

gacuccgucu ggaacuucca cgucuggacc gacgccugga ugaagcgccc cgaccucccc     1020

aagggcuacg acggcuggca ggccgucgac gccacccccc aggagcgcuc ccagggcguc     1080

uucugcugcg gccccucccc ccucaccgcc auccgcaagg gcgacaucuu caucgucuac     1140

gacacccgcu ucgucuucuc cgaggucaac ggcgaccgcc ucaucuggcu cgucaagaug     1200

gucaacggcc aggaggagcu ccacgucauc uccauggaga ccaccuccau cggcaagaac     1260

aucuccacca aggccgucgg ccaggaccgc cgccgcgaca ucaccuacga guacaaguac     1320

cccgagggcu ccuccgagga gcgccagguc auggaccacg ccuuccuccu ccucuccucc     1380

gagcgcgagc accgccgccc cgucaaggag aacuuccucc acauguccgu ccaguccgac     1440

gacguccucc ucggcaacuc cgucaacuuc accgucaucc ucaagcgcaa gaccgccgcc     1500

cuccagaacg ucaacauccu cggcuccuuc gagcuccagc ucuacaccgg caagaagaug     1560

gccaagcucu gcgaccucaa caagaccucc cagauccagg gccaggucuc cgaggucacc     1620

cucacccucg acuccaagac cuacaucaac ucccucgcca uccucgacga cgagcccguc     1680

auccgcggcu ucaucaucgc cgagaucguc gaguccaagg agaucauggc cuccgagguc     1740

uucaccuccu uccaguaccc cgaguucucc aucgagcucc ccaacaccgg ccgcaucggc     1800

cagcuccucg ucugcaacug caucuucaag aacacccucg ccaucccccu caccgacguc     1860

aaguucuccc ucgagucccu cggcaucucc ucccuccaga ccuccgacca cggcaccguc     1920

cagcccggcg agaccaucca gucccagauc aagugcaccc ccaucaagac cggccccaag     1980

aaguucaucg ucaagcucuc cuccaagcag gucaaggaga ucaacgccca gaagaucguc     2040

cucaucacca aguga                                                      2055


<210>  3636
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGM-4__Homo_sapiens__BAG35778

<400>  3636
augauggacg ccagcaagga gcugcaagug cuccacaucg auuuccuuaa ccaagacaau       60

gcugucuccc aucacaccug ggaauuucag acaucuucac ccguuuucag aaggggccag      120

guguuucauc ugcgguuggu auuaaaccag ccuccacaaa guuaccacca gcugaaacua      180

gaguucagca cugggccgaa ucccuccauu gcaaagcaua cgcucguggu ccuggauccu      240

cgcaccccau cugaccacua uaacuggcag gccacacuuc agaaugaauc gggaaaagag      300

gugacuguug cggugaccuc aagccccaac gcuauacugg guaaguacca auugaauguc      360

aaaacaggca accacauccu caagagugaa gagaauauuc uguaucugcu cuuuaacccu      420

uggugcaagg aggauauggu guucaugcca gacgaagaug agcgaaaaga auacaucuua      480

aaugacaccg ggugucauua uguaggagcc gcacguucca uuaagugcaa acccuggaac      540

uuuggccagu ucgagaagaa uguucuggau uguugcaucu cucuuuugac ugagagcucc      600

cugaaaccua cagacagaag ggauccagug cuagucuguc gggccaugug cgcuaugaug      660

ucauuugaaa agggucaggg ggugcucaua ggaaacugga ccggcgacua cgagggcggg      720

acggcaccgu auaaguggac uggaagugcc cccauccugc agcaauacua caauaccaaa      780

caggcugugu guuucgguca gugcuggguc uuugccggca uucuuacaac uguucugcgc      840

gcguugggga ucccugcaag aagcgugacc ggauucgauu cugcccacga cacagaaagg      900

aaccucaccg uagacacgua ugugaacgag aauggcgaaa agauuacuuc caugacacau      960

gauucagucu ggaacuuuca cguguggacc gacgcuugga ugaaacggcc agaucugccc     1020

aaggguuacg acggguggca agccguugau gcaacuccuc aggagcgcag ccagggagug     1080

uucuguugcg gcccaagucc cuuaacagcu auccgaaaag gcgacauauu cauugucuau     1140

gauaccagau uuguguucuc ugagguaaau ggggacaggc ugaucuggcu cguuaagaug     1200

gugaacggac aggaggaacu ucacgucauu uccauggaaa cgaccagcau cgguaaaaau     1260

aucucgacaa aggccguggg ccaagaucgg cgucgcgaca uuacuuacga guauaaguac     1320

ccggaagggu cuuccgagga gagacagguc auggaucaug cguuucuguu gcuaucaagu     1380

gaaagggagc accggcgacc ugugaaagaa aacuuccugc auaugagcgu ucaguccgac     1440

gacgugcucc ugggaaauuc uguaaacuuu accgucauac uuaagcgcaa aacagccgca     1500

cugcagaaug ugaacaucuu gggcagcuuc gagcuccaac uguauacugg uaagaaaaug     1560

gcuaaguuau gugaucugaa uaagaccuca cagauucagg ggcagguuag ugaagugaca     1620

cuaacccucg acuccaaaac uuacaucaac agccuggcca uacuugauga cgagcccguc     1680

auuagaggcu uuaucaucgc ugagauugug gaaucuaagg agaucauggc cucagaagua     1740

uucacgaguu uucaauaccc agaguucagc auugaguugc cuaauacagg aaggauaggc     1800

cagcugcucg ugugcaacug caucuuuaaa aauacccugg caauuccccu uacugauguu     1860

aaguucuccc uggaaucuuu ggggaucucg agccuccaga ccuccgacca cggaacaguc     1920

cagccaggug agaccaucca aucacagauu aaauguacuc ccauaaagac aggcccuaag     1980

aaauuuaucg ugaagcugag uucuaaacag gugaaggaaa uuaacgccca gaaaaucguc     2040

uuaauuacga aguga                                                      2055


<210>  3637
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGM-4__Homo_sapiens__BAG35778

<400>  3637
augauggacg ccagcaagga gcugcaggug cugcacaucg acuuccugaa ccaggacaac       60

gccgugagcc accacaccug ggaguuccag accagcagcc ccguguucag aagaggccag      120

guguuccacc ugagacuggu gcugaaccag cccccccaga gcuaccacca gcugaagcug      180

gaguucagca ccggccccaa ccccagcauc gccaagcaca cccugguggu gcuggacccc      240

agaaccccca gcgaccacua caacuggcag gccacccugc agaacgagag cggcaaggag      300

gugaccgugg ccgugaccag cagccccaac gccauccugg gcaaguacca gcugaacgug      360

aagaccggca accacauccu gaagagcgag gagaacaucc uguaccugcu guucaacccc      420

uggugcaagg aggacauggu guucaugccc gacgaggacg agagaaagga guacauccug      480

aacgacaccg gcugccacua cgugggcgcc gccagaagca ucaagugcaa gcccuggaac      540

uucggccagu ucgagaagaa cgugcuggac ugcugcauca gccugcugac cgagagcagc      600

cugaagccca ccgacagaag agaccccgug cuggugugca gagccaugug cgccaugaug      660

agcuucgaga agggccaggg cgugcugauc ggcaacugga ccggcgacua cgagggcggc      720

accgcccccu acaaguggac cggcagcgcc cccauccugc agcaguacua caacaccaag      780

caggccgugu gcuucggcca gugcugggug uucgccggca uccugaccac cgugcugaga      840

gcccugggca uccccgccag aagcgugacc ggcuucgaca gcgcccacga caccgagaga      900

aaccugaccg uggacaccua cgugaacgag aacggcgaga agaucaccag caugacccac      960

gacagcgugu ggaacuucca cguguggacc gacgccugga ugaagagacc cgaccugccc     1020

aagggcuacg acggcuggca ggccguggac gccacccccc aggagagaag ccagggcgug     1080

uucugcugcg gccccagccc ccugaccgcc aucagaaagg gcgacaucuu caucguguac     1140

gacaccagau ucguguucag cgaggugaac ggcgacagac ugaucuggcu ggugaagaug     1200

gugaacggcc aggaggagcu gcacgugauc agcauggaga ccaccagcau cggcaagaac     1260

aucagcacca aggccguggg ccaggacaga agaagagaca ucaccuacga guacaaguac     1320

cccgagggca gcagcgagga gagacaggug auggaccacg ccuuccugcu gcugagcagc     1380

gagagagagc acagaagacc cgugaaggag aacuuccugc acaugagcgu gcagagcgac     1440

gacgugcugc ugggcaacag cgugaacuuc accgugaucc ugaagagaaa gaccgccgcc     1500

cugcagaacg ugaacauccu gggcagcuuc gagcugcagc uguacaccgg caagaagaug     1560

gccaagcugu gcgaccugaa caagaccagc cagauccagg gccaggugag cgaggugacc     1620

cugacccugg acagcaagac cuacaucaac agccuggcca uccuggacga cgagcccgug     1680

aucagaggcu ucaucaucgc cgagaucgug gagagcaagg agaucauggc cagcgaggug     1740

uucaccagcu uccaguaccc cgaguucagc aucgagcugc ccaacaccgg cagaaucggc     1800

cagcugcugg ugugcaacug caucuucaag aacacccugg ccaucccccu gaccgacgug     1860

aaguucagcc uggagagccu gggcaucagc agccugcaga ccagcgacca cggcaccgug     1920

cagcccggcg agaccaucca gagccagauc aagugcaccc ccaucaagac cggccccaag     1980

aaguucaucg ugaagcugag cagcaagcag gugaaggaga ucaacgccca gaagaucgug     2040

cugaucacca aguga                                                      2055


<210>  3638
<211>  2055
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGM-4__Homo_sapiens__BAG35778

<400>  3638
augauggacg ccagcaagga gcuccaggug cugcacaucg auuuccugaa ccaagacaau       60

gcugucuccc aucacaccug ggaauuucag acaucuagcc ccguuuucag acggggccag      120

guguuucauc uucgccuggu gcucaaccag ccuccgcaau ccuaccacca gcugaaacuu      180

gaguucucua cggggcccaa uccuagcauu gccaagcaua cccuggucgu gcucgauccc      240

agaacaccuu ccgaccacua uaacuggcag gcgacccugc agaaugaauc uggaaaagag      300

guuacagugg cugucaccag cucccccaac gccauccugg gcaaguacca acucaaugug      360

aaaacaggga accacauucu gaaaagcgaa gagaauaucc uuuaucugcu cuuuaacccu      420

uggugcaagg aggauauggu uuucaugccg gacgaagaug agcggaaaga auacauucug      480

aaugacaccg gaugucauua ugugggcgcc gcucgcucua ucaagugcaa acccuggaac      540

uuugggcagu ucgagaagaa uguccuugau uguugcaucu cccugcucac ggagagcucu      600

cugaaaccua ccgacagacg ggaucccgug cugguguguc gcgccaugug cgcuaugaug      660

uccuuugaaa agggacaggg cguccucauu ggcaacugga caggggacua cgagggaggc      720

accgccccuu auaaguggac agggagcgcg cccauccugc agcaauacua caauaccaaa      780

caggccguuu guuucggaca gugcugggug uuugcuggca uucuuacgac agugcugaga      840

gcccucggga ucccggcucg gucugucacc ggauucgauu ccgcccacga cacagaacgc      900

aaccugaccg uggacaccua uguuaacgag aauggcgaaa agauuacaag caugacgcau      960

gauuccgugu ggaacuuuca cgucuggacc gacgcgugga ugaaaagacc ugaucuuccc     1020

aagggcuacg acggguggca agccguggau gcuacaccuc aggagcgguc ucagggaguu     1080

uucuguugcg gccccagccc ccugaccgcc auccgcaaag gggacauuuu caucguguau     1140

gauacaagau uugucuucuc cgaggugaau ggagaccggc ucaucuggcu ggucaagaug     1200

gugaacggcc aggaggaacu gcacguuauu agcauggaaa ccacgucuau cgggaaaaau     1260

auuuccacaa aggcuguggg acaagaucgc agacgggaca ucaccuacga guauaaguac     1320

ccugaaggca gcucugagga gagacagguc auggaucaug ccuuucuccu gcuuagcucc     1380

gaacgcgagc accggagacc ggugaaagaa aacuuccugc auaugucugu ucagagcgac     1440

gacgugcucc ugggcaauuc cgucaacuuu accgugauuc uuaagcgcaa aacagccgcu     1500

cugcagaaug ugaacauccu cgggagcuuc gagcugcaac uguauaccgg aaagaaaaug     1560

gcgaagcucu gugaucugaa uaagacaucu cagauccagg gccagguuuc cgaagucacg     1620

cuuacccugg acagcaaaac auacauuaac ucucucgcca uccuggauga cgagcccgug     1680

auucgggggu uuaucauugc ugagaucgug gaauccaagg agaucauggc cagcgaaguc     1740

uucaccuccu uucaauaccc ugaguucucu auugagcugc ccaauacagg aagaaucggc     1800

cagcuucucg ugugcaacug cauuuuuaaa aauacccugg ccaucccucu gacggauguu     1860

aaguucagcc ucgaaucccu ggggauuucu agccuucaga ccuccgacca cggcacagug     1920

cagcccggag agaccaucca aagccagauu aaauguacac cgaucaagac cggcccuaag     1980

aaauuuaucg ucaagcuguc uuccaaacag gugaaggaaa uuaacgcuca aaagaucguu     2040

cucauuacga aguga                                                      2055


<210>  3639
<211>  1124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIE2__Homo_sapiens__Q02763

<400>  3639

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Ile Gln Arg Met Thr Pro Lys Ile 
            340                 345                 350         


Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             


Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 


Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 


Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     


Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met 
            420                 425                 430         


Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             


Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 


Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 


Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln 
                485                 490                 495     


Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu 
            500                 505                 510         


Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             


His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 


Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 


Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     


Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         


Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             


Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 


Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 


Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     


Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         


Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys 
        675                 680                 685             


Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 


Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 


Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln 
                725                 730                 735     


Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         


Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             


Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 


Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 


Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     


Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         


Val Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu 
        995                 1000                1005            


Ser Leu Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr 
    1010                1015                1020                


Gly Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys 
1025                1030                1035                1040


Gly Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg 
                1045                1050                1055    


Leu Glu Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg 
            1060                1065                1070        


Gln Cys Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile 
        1075                1080                1085            


Leu Val Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn 
    1090                1095                1100                


Thr Thr Leu Tyr Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala 
1105                1110                1115                1120


Glu Glu Ala Ala 
                


<210>  3640
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIE2__Homo_sapiens__CCDS6519.1

<400>  3640
auggacucuu uagccagcuu aguucucugu ggagucagcu ugcuccuuuc uggaacugug       60

gaaggugcca uggacuugau cuugaucaau ucccuaccuc uuguaucuga ugcugaaaca      120

ucucucaccu gcauugccuc uggguggcgc ccccaugagc ccaucaccau aggaagggac      180

uuugaagccu uaaugaacca gcaccaggau ccgcuggaag uuacucaaga ugugaccaga      240

gaaugggcua aaaaaguugu uuggaagaga gaaaaggcua guaagaucaa uggugcuuau      300

uucugugaag ggcgaguucg aggagaggca aucaggauac gaaccaugaa gaugcgucaa      360

caagcuuccu uccuaccagc uacuuuaacu augacugugg acaagggaga uaacgugaac      420

auaucuuuca aaaagguauu gauuaaagaa gaagaugcag ugauuuacaa aaaugguucc      480

uucauccauu cagugccccg gcaugaagua ccugauauuc uagaaguaca ccugccucau      540

gcucagcccc aggaugcugg aguguacucg gccagguaua uaggaggaaa ccucuucacc      600

ucggccuuca ccaggcugau aguccggaga ugugaagccc agaagugggg accugaaugc      660

aaccaucucu guacugcuug uaugaacaau ggugucugcc augaagauac uggagaaugc      720

auuugcccuc cuggguuuau gggaaggacg ugugagaagg cuugugaacu gcacacguuu      780

ggcagaacuu guaaagaaag gugcagugga caagagggau gcaagucuua uguguucugu      840

cucccugacc ccuaugggug uuccugugcc acaggcugga agggucugca gugcaaugaa      900

gcaugccacc cugguuuuua cgggccagau uguaagcuua ggugcagcug caacaauggg      960

gagaugugug aucgcuucca aggaugucuc ugcucuccag gauggcaggg gcuccagugu     1020

gagagagaag gcauacagag gaugacccca aagauagugg auuugccaga ucauauagaa     1080

guaaacagug guaaauuuaa ucccauuugc aaagcuucug gcuggccgcu accuacuaau     1140

gaagaaauga cccuggugaa gccggauggg acagugcucc auccaaaaga cuuuaaccau     1200

acggaucauu ucucaguagc cauauucacc auccaccgga uccucccccc ugacucagga     1260

guuugggucu gcagugugaa cacaguggcu gggauggugg aaaagcccuu caacauuucu     1320

guuaaaguuc uuccaaagcc ccugaaugcc ccaaacguga uugacacugg acauaacuuu     1380

gcugucauca acaucagcuc ugagccuuac uuuggggaug gaccaaucaa auccaagaag     1440

cuucuauaca aacccguuaa ucacuaugag gcuuggcaac auauucaagu gacaaaugag     1500

auuguuacac ucaacuauuu ggaaccucgg acagaauaug aacucugugu gcaacugguc     1560

cgucguggag agggugggga agggcauccu ggaccuguga gacgcuucac aacagcuucu     1620

aucggacucc cuccuccaag aggucuaaau cuccugccua aaagucagac cacucuaaau     1680

uugaccuggc aaccaauauu uccaagcucg gaagaugacu uuuauguuga aguggagaga     1740

aggucugugc aaaaaaguga ucagcagaau auuaaaguuc caggcaacuu gacuucggug     1800

cuacuuaaca acuuacaucc cagggagcag uacguggucc gagcuagagu caacaccaag     1860

gcccaggggg aauggaguga agaucucacu gcuuggaccc uuagugacau ucuuccuccu     1920

caaccagaaa acaucaagau uuccaacauu acacacuccu cagcugugau uucuuggaca     1980

auauuggaug gcuauucuau uucuucuauu acuauccguu acaagguuca aggcaagaau     2040

gaagaccagc acguugaugu gaagauaaag aaugccacca ucacucagua ucagcucaag     2100

ggccuagagc cugaaacagc auaccaggug gacauuuuug cagagaacaa cauaggguca     2160

agcaacccag ccuuuucuca ugaacuggug acccucccag aaucucaagc accagcggac     2220

cucggagggg ggaagaugcu gcuuauagcc auccuuggcu cugcuggaau gaccugccug     2280

acugugcugu uggccuuucu gaucauauug caauugaaga gggcaaaugu gcaaaggaga     2340

auggcccaag ccuuccaaaa cgugagggaa gaaccagcug ugcaguucaa cucagggacu     2400

cuggcccuaa acaggaaggu caaaaacaac ccagauccua caauuuaucc agugcuugac     2460

uggaaugaca ucaaauuuca agaugugauu ggggagggca auuuuggcca aguucuuaag     2520

gcgcgcauca agaaggaugg guuacggaug gaugcugcca ucaaaagaau gaaagaauau     2580

gccuccaaag augaucacag ggacuuugca ggagaacugg aaguucuuug uaaacuugga     2640

caccauccaa acaucaucaa ucucuuagga gcaugugaac aucgaggcua cuuguaccug     2700

gccauugagu acgcgcccca uggaaaccuu cuggacuucc uucgcaagag ccgugugcug     2760

gagacggacc cagcauuugc cauugccaau agcaccgcgu ccacacuguc cucccagcag     2820

cuccuucacu ucgcugccga cguggcccgg ggcauggacu acuugagcca aaaacaguuu     2880

auccacaggg aucuggcugc cagaaacauu uuaguuggug aaaacuaugu ggcaaaaaua     2940

gcagauuuug gauugucccg aggucaagag guguauguga aaaagacaau gggaaggcuc     3000

ccagugcgcu ggauggccau cgagucacug aauuacagug uguacacaac caacagugau     3060

guaugguccu augguguguu acuaugggag auuguuagcu uaggaggcac acccuacugc     3120

gggaugacuu gugcagaacu cuacgagaag cugccccagg gcuacagacu ggagaagccc     3180

cugaacugug augaugaggu guaugaucua augagacaau gcuggcggga gaagccuuau     3240

gagaggccau cauuugccca gauauuggug uccuuaaaca gaauguuaga ggagcgaaag     3300

accuacguga auaccacgcu uuaugagaag uuuacuuaug caggaauuga cuguucugcu     3360

gaagaagcgg ccuag                                                      3375


<210>  3641
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIE2__Homo_sapiens__CCDS6519.1

<400>  3641
auggacagcc uggccucccu cgugcugugc ggcgucagcc ugcuccuguc cgggaccgug       60

gagggcgcca uggaccugau ccucaucaac agccugcccc ugguguccga cgcggagacc      120

agccucacgu gcaucgccuc cggguggcgc ccgcacgagc ccaucaccau cggccgggac      180

uucgaggccc ugaugaacca gcaccaggac ccccuggagg ucacccagga cgugacccgc      240

gagugggcca agaagguggu cuggaagcgg gagaaggcca gcaagaucaa cggggcguac      300

uucugcgagg gccgcgugcg gggcgaggcc auccgcaucc ggacgaugaa gaugcgccag      360

caggccuccu uccuccccgc cacccugacc augaccgugg acaaggggga caacgucaac      420

aucagcuuca agaaggugcu gaucaaggag gaggacgcgg ugaucuacaa gaacggcucc      480

uucauccaca gcgucccgcg gcacgaggug cccgacaucc ucgaggugca ccucccccac      540

gcccagcccc aggacgccgg ggucuacucc gcccgcuaca ucggcgggaa ccuguucacg      600

agcgccuuca cccggcucau cgugcgccgg ugcgaggcgc agaagugggg cccggagugc      660

aaccaccugu gcaccgccug caugaacaac ggcgugugcc acgaggacac cggggagugc      720

aucugcccgc ccggcuucau ggggcgcacg ugcgagaagg ccugcgagcu gcacaccuuc      780

ggccggaccu gcaaggagcg cugcuccggc caggaggggu gcaagagcua cgucuucugc      840

cuccccgacc ccuacggcug cuccugcgcc accgggugga agggccugca gugcaacgag      900

gccugccacc ccggguucua cggccccgac ugcaagcugc ggugcagcug caacaacggc      960

gagaugugcg accgcuucca ggggugccuc ugcucccccg gcuggcaggg gcugcagugc     1020

gagcgggagg gcauccagcg caugacgccg aagaucgugg accugcccga ccacaucgag     1080

gugaacagcg ggaaguucaa ccccaucugc aaggcgagcg gcuggccccu cccgaccaac     1140

gaggagauga cccuggucaa gcccgacggc accgugcugc accccaagga cuucaaccac     1200

acggaccacu ucuccguggc caucuucacc auccaccgga uccugccccc ggacagcggg     1260

gucugggugu gcuccgucaa caccguggcc ggcauggugg agaagcccuu caacaucagc     1320

gucaaggugc ugcccaagcc ccugaacgcc ccgaacguga ucgacaccgg gcacaacuuc     1380

gccgucauca acaucuccag cgagcccuac uucggcgacg ggcccaucaa guccaagaag     1440

cuccuguaca agccggugaa ccacuacgag gcguggcagc acauccaggu gacgaacgag     1500

aucgucaccc ugaacuaccu cgagccccgc accgaguacg agcugugcgu gcagcuggug     1560

cgccggggcg agggcgggga gggccacccc gggcccgucc gccgguucac cacggccagc     1620

aucggccucc cgccgccccg cggccugaac cugcucccca agucccagac cacccugaac     1680

cugaccuggc agcccaucuu ccccagcucc gaggacgacu ucuacgugga gguggagcgg     1740

cgcagcgucc agaaguccga ccagcagaac aucaaggugc ccgggaaccu cacgagcgug     1800

cugcugaaca accuccaccc ccgggagcag uacgucgugc gcgcccgggu gaacaccaag     1860

gcccagggcg agugguccga ggaccugacc gccuggaccc ugagcgacau ccugccgccc     1920

cagcccgaga acaucaagau cuccaacauc acgcacagcu ccgcggucau cagcuggacc     1980

auccucgacg gguacagcau cuccagcauc accauccgcu acaaggugca gggcaagaac     2040

gaggaccagc acguggacgu caagaucaag aacgccacca ucacccagua ccagcugaag     2100

gggcuggagc ccgagacggc cuaccaggug gacaucuucg ccgagaacaa caucggcucc     2160

agcaacccgg cguucuccca cgagcucgug acccugcccg agagccaggc ccccgccgac     2220

cugggcgggg gcaagaugcu ccugaucgcc auccuggggu ccgccggcau gaccugccuc     2280

accguccugc uggcguuccu caucauccug cagcugaagc gggccaacgu gcagcgccgg     2340

auggcccagg ccuuccagaa cgugcgcgag gagcccgccg uccaguucaa cagcgggacg     2400

cucgcgcuga accggaaggu gaagaacaac ccggacccca ccaucuaccc cgugcuggac     2460

uggaacgaca ucaaguucca ggacgucauc ggcgagggca acuucggcca ggugcucaag     2520

gcccgcauca agaaggacgg gcugcggaug gacgccgcca ucaagcgcau gaaggaguac     2580

gccuccaagg acgaccaccg ggacuucgcg ggggagcugg aggugcucug caagcugggc     2640

caccacccca acaucaucaa ccugcucggg gccugcgagc accgcggcua ccuguaccug     2700

gccaucgagu acgccccgca cggcaaccuc cuggacuucc ugcgcaagag ccggguccuc     2760

gagaccgacc ccgcguucgc caucgccaac uccaccgcca gcacgcuguc cagccagcag     2820

cugcuccacu ucgccgcgga cguggcccgc gggauggacu accuguccca gaagcaguuc     2880

auccaccggg accuggccgc ccgcaacauc cucgugggcg agaacuacgu cgccaagauc     2940

gcggacuucg ggcugagccg gggccaggag guguacguga agaagaccau ggggcgccug     3000

cccguccggu ggauggccau cgagucccuc aacuacagcg uguacaccac caacagcgac     3060

gugugguccu acggcguccu gcugugggag aucgugagcc ucggcgggac gccguacugc     3120

ggcaugaccu gcgccgagcu guacgagaag cugccccagg gguaccgccu cgagaagccc     3180

cugaacugcg acgacgaggu guacgaccug augcggcagu gcuggcgcga gaagcccuac     3240

gagcggccgu ccuucgccca gauccucguc agccugaacc gcaugcugga ggagcggaag     3300

accuacguga acaccacgcu cuacgagaag uucaccuacg ccggcaucga cugcuccgcg     3360

gaggaggccg ccuga                                                      3375


<210>  3642
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIE2__Homo_sapiens__CCDS6519.1

<400>  3642
auggacuccc ucgccucccu cguccucugc ggcgucuccc uccuccucuc cggcaccguc       60

gagggcgcca uggaccucau ccucaucaac ucccuccccc ucgucuccga cgccgagacc      120

ucccucaccu gcaucgccuc cggcuggcgc ccccacgagc ccaucaccau cggccgcgac      180

uucgaggccc ucaugaacca gcaccaggac ccccucgagg ucacccagga cgucacccgc      240

gagugggcca agaaggucgu cuggaagcgc gagaaggccu ccaagaucaa cggcgccuac      300

uucugcgagg gccgcguccg cggcgaggcc auccgcaucc gcaccaugaa gaugcgccag      360

caggccuccu uccuccccgc cacccucacc augaccgucg acaagggcga caacgucaac      420

aucuccuuca agaagguccu caucaaggag gaggacgccg ucaucuacaa gaacggcucc      480

uucauccacu ccgucccccg ccacgagguc cccgacaucc ucgaggucca ccucccccac      540

gcccagcccc aggacgccgg cgucuacucc gcccgcuaca ucggcggcaa ccucuucacc      600

uccgccuuca cccgccucau cguccgccgc ugcgaggccc agaagugggg ccccgagugc      660

aaccaccucu gcaccgccug caugaacaac ggcgucugcc acgaggacac cggcgagugc      720

aucugccccc ccggcuucau gggccgcacc ugcgagaagg ccugcgagcu ccacaccuuc      780

ggccgcaccu gcaaggagcg cugcuccggc caggagggcu gcaaguccua cgucuucugc      840

cuccccgacc ccuacggcug cuccugcgcc accggcugga agggccucca gugcaacgag      900

gccugccacc ccggcuucua cggccccgac ugcaagcucc gcugcuccug caacaacggc      960

gagaugugcg accgcuucca gggcugccuc ugcucccccg gcuggcaggg ccuccagugc     1020

gagcgcgagg gcauccagcg caugaccccc aagaucgucg accuccccga ccacaucgag     1080

gucaacuccg gcaaguucaa ccccaucugc aaggccuccg gcuggccccu ccccaccaac     1140

gaggagauga cccucgucaa gcccgacggc accguccucc accccaagga cuucaaccac     1200

accgaccacu ucuccgucgc caucuucacc auccaccgca uccucccccc cgacuccggc     1260

gucugggucu gcuccgucaa caccgucgcc ggcauggucg agaagcccuu caacaucucc     1320

gucaaggucc uccccaagcc ccucaacgcc cccaacguca ucgacaccgg ccacaacuuc     1380

gccgucauca acaucuccuc cgagcccuac uucggcgacg gccccaucaa guccaagaag     1440

cuccucuaca agcccgucaa ccacuacgag gccuggcagc acauccaggu caccaacgag     1500

aucgucaccc ucaacuaccu cgagccccgc accgaguacg agcucugcgu ccagcucguc     1560

cgccgcggcg agggcggcga gggccacccc ggccccgucc gccgcuucac caccgccucc     1620

aucggccucc cccccccccg cggccucaac cuccucccca agucccagac cacccucaac     1680

cucaccuggc agcccaucuu ccccuccucc gaggacgacu ucuacgucga ggucgagcgc     1740

cgcuccgucc agaaguccga ccagcagaac aucaaggucc ccggcaaccu caccuccguc     1800

cuccucaaca accuccaccc ccgcgagcag uacgucgucc gcgcccgcgu caacaccaag     1860

gcccagggcg agugguccga ggaccucacc gccuggaccc ucuccgacau ccuccccccc     1920

cagcccgaga acaucaagau cuccaacauc acccacuccu ccgccgucau cuccuggacc     1980

auccucgacg gcuacuccau cuccuccauc accauccgcu acaaggucca gggcaagaac     2040

gaggaccagc acgucgacgu caagaucaag aacgccacca ucacccagua ccagcucaag     2100

ggccucgagc ccgagaccgc cuaccagguc gacaucuucg ccgagaacaa caucggcucc     2160

uccaaccccg ccuucuccca cgagcucguc acccuccccg agucccaggc ccccgccgac     2220

cucggcggcg gcaagaugcu ccucaucgcc auccucggcu ccgccggcau gaccugccuc     2280

accguccucc ucgccuuccu caucauccuc cagcucaagc gcgccaacgu ccagcgccgc     2340

auggcccagg ccuuccagaa cguccgcgag gagcccgccg uccaguucaa cuccggcacc     2400

cucgcccuca accgcaaggu caagaacaac cccgacccca ccaucuaccc cguccucgac     2460

uggaacgaca ucaaguucca ggacgucauc ggcgagggca acuucggcca gguccucaag     2520

gcccgcauca agaaggacgg ccuccgcaug gacgccgcca ucaagcgcau gaaggaguac     2580

gccuccaagg acgaccaccg cgacuucgcc ggcgagcucg agguccucug caagcucggc     2640

caccacccca acaucaucaa ccuccucggc gccugcgagc accgcggcua ccucuaccuc     2700

gccaucgagu acgcccccca cggcaaccuc cucgacuucc uccgcaaguc ccgcguccuc     2760

gagaccgacc ccgccuucgc caucgccaac uccaccgccu ccacccucuc cucccagcag     2820

cuccuccacu ucgccgccga cgucgcccgc ggcauggacu accucuccca gaagcaguuc     2880

auccaccgcg accucgccgc ccgcaacauc cucgucggcg agaacuacgu cgccaagauc     2940

gccgacuucg gccucucccg cggccaggag gucuacguca agaagaccau gggccgccuc     3000

cccguccgcu ggauggccau cgagucccuc aacuacuccg ucuacaccac caacuccgac     3060

gucugguccu acggcguccu ccucugggag aucgucuccc ucggcggcac ccccuacugc     3120

ggcaugaccu gcgccgagcu cuacgagaag cucccccagg gcuaccgccu cgagaagccc     3180

cucaacugcg acgacgaggu cuacgaccuc augcgccagu gcuggcgcga gaagcccuac     3240

gagcgccccu ccuucgccca gauccucguc ucccucaacc gcaugcucga ggagcgcaag     3300

accuacguca acaccacccu cuacgagaag uucaccuacg ccggcaucga cugcuccgcc     3360

gaggaggccg ccuga                                                      3375


<210>  3643
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIE2__Homo_sapiens__CCDS6519.1

<400>  3643
auggacagcc uggccucccu cgugcuuugc ggcgucucuc uguuguuauc agggaccguu       60

gagggagcua uggaucugau ccuaauuaac agucuccccc uggugagcga cgcagaaaca      120

ucccuuacuu guauagccuc ugguuggaga ccucacgagc caaucacgau uggcagggau      180

uucgaagcgc ugaugaauca gcaucaagac ccguuggagg uaacccagga ugugacacgg      240

gaaugggcua agaaagucgu guggaagcgc gagaaagccu cgaagaucaa cggggcauac      300

uuuugcgagg gacgaguucg uggcgaagcc auuagaauca ggacuaugaa aaugcggcag      360

caggcuucau uccuccccgc aacccugaca augaccgugg acaaggguga uaaugucaac      420

aucagcuuua agaaagugcu gauaaaggag gaagacgccg uaauuuauaa aaaugggagu      480

uucauccacu ccguuccucg ccaugaggug ccagauauuc ucgaggucca cuuaccccau      540

gcucaaccuc aggacgccgg aguguacucu gcgagauaua ucggcggcaa ccuguuuacu      600

agcgcauuca caaggcuuau agugcggcgc ugugaagccc agaagugggg gccagagugc      660

aaucacuugu guaccgcuug caugaacaau ggagucuguc acgaagauac gggugagugc      720

auuugucccc cuggcuuuau ggggcgaacu ugcgaaaaag ccugugagcu gcauaccuuc      780

ggaagaacau gcaaggagag gugcuccggc caggaagguu guaagucaua cguguuuugc      840

cuaccagacc cguaugggug uaguugcgca acuggaugga aaggccucca auguaacgag      900

gcuugccacc ccggcuucua cgggccugau uguaagcugc ggugcagcug uaauaacgga      960

gaaaugugcg accguuuuca ggguugucuu ugcucuccag gcuggcaggg gcugcagugc     1020

gagcgcgaag gaauccaaag aaugaccccc aaaauuguug acuugccuga ucauaucgag     1080

guaaauuccg gcaaguucaa cccaaucugu aaagccucag guuggccccu cccgacaaau     1140

gaggaaauga cccuggugaa gccugacggg acggucuuac accccaaaga uuuuaaccac     1200

acugaccauu ucagcguggc gauuuucaca auacacagga uccugccacc ugauaguggc     1260

guuugggugu gcucugucaa caccguggcc ggaaugguag agaagcccuu uaauauuucc     1320

guuaaggugc ucccaaaacc ccuuaacgca ccuaauguca ucgacacugg ccauaacuuc     1380

gcugugauaa auauuagcuc ggaaccauau uuuggggaug gaccgaucaa gucuaaaaag     1440

cuguuguaca aacccgucaa ccacuacgag gccuggcagc auauccaggu gacaaaugaa     1500

auuguuaccc uaaacuaucu ggagccucgg acggaguacg aacucugugu gcaacuggua     1560

cgacgcggug agggcgggga aggacaccca ggccccguca gaagguucac cacagcuucc     1620

aucggucuuc cuccaccccg ggggcugaau uugcucccga agucacagac uacccugaac     1680

uuaacauggc agccuauuuu uccaaguagc gaggacgauu ucuaugugga gguugaacgc     1740

agauccgugc agaagucuga ccaacagaau auaaaagucc ccggcaaccu gacuagcgug     1800

cuacucaaua accugcaccc uagggagcag uacguagugc gugcccgggu uaauaccaag     1860

gcacagggag aauggucaga ggaucuuaca gccuggaccu ugagugacau ccugccccca     1920

caaccugaaa acauuaaaau cuccaacauc acucauagcu cugcugucau uucauggacg     1980

auacucgacg gcuauaguau cagcuccauu acaauccgau acaaggugca ggggaaaaau     2040

gaggaucagc acguggacgu caagauuaag aacgcgacca ucacucagua ucaacugaaa     2100

ggacuugagc ccgaaaccgc auaccagguu gauauauuug ccgagaauaa caucgguucu     2160

ucgaauccag cuuucagcca ugaacuggug acauugccgg agucccaggc cccugcagac     2220

cucggcgggg gaaagaugcu guuaauugcc auccugggcu cagcugguau gaccugccua     2280

acugugcucc uggccuuucu uauuaucuug cagcugaaaa gagcaaacgu acaaaggcgc     2340

auggcgcagg cuuuccagaa uguccgggaa gaacccgccg ugcaauuuaa cagugggaca     2400

cucgcacuga auagaaaggu uaaaaacaau ccagauccca cgauauaccc uguguuagac     2460

uggaacgaua uuaaguucca ggacgucauc ggcgagggaa auuuuggcca ggugcugaag     2520

gccaggauua aaaaggaugg gcuucgcaug gacgcugcca ucaaacgaau gaaggaauau     2580

gcaucuaaag augaccaccg ggauuucgcu ggagaguugg aaguucucug uaagcugggc     2640

caccauccaa acauaaucaa ucuacugggu gccugcgagc accgugggua ccucuaucug     2700

gcgauugaau acgcucccca uggaaaccuu uuggacuucc ugagaaaaag caggguguua     2760

gagaccgacc cugccuuugc aaucgccaac uccacugcuu caacacucag cucucagcaa     2820

cugcuucacu ucgccgcaga uguagcgcgc ggcauggacu aucuguccca gaagcaguuu     2880

auucaucggg auuuggccgc uagaaauauc cucgucggug agaacuacgu ggccaagaua     2940

gcagacuucg gccugaguag ggggcaggaa guguauguca aaaagaccau gggacgacua     3000

ccgguucgcu ggauggcuau ugagagccug aauuacucug uguacacaac uaacuccgau     3060

guauggucau auggcgugcu ccugugggaa aucgucaguc uugggggaac cccauacugu     3120

ggcaugacgu gcgccgaguu guaugagaaa cugccccaag guuaccgguu agaaaagccu     3180

cucaauugug acgaugaggu guaugaccug augagacagu gcuggaggga aaaaccauac     3240

gagcguccca gcuuugcaca gauccuuguu ucgcugaacc gcaugcuaga ggagcggaag     3300

accuauguga auacaacucu cuacgagaag uucaccuacg ccgggauuga uuguuccgcu     3360

gaagaggcgg ccuga                                                      3375


<210>  3644
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIE2__Homo_sapiens__CCDS6519.1

<400>  3644
auggacagcc uggccagccu ggugcugugc ggcgugagcc ugcugcugag cggcaccgug       60

gagggcgcca uggaccugau ccugaucaac agccugcccc uggugagcga cgccgagacc      120

agccugaccu gcaucgccag cggcuggaga ccccacgagc ccaucaccau cggcagagac      180

uucgaggccc ugaugaacca gcaccaggac ccccuggagg ugacccagga cgugaccaga      240

gagugggcca agaagguggu guggaagaga gagaaggcca gcaagaucaa cggcgccuac      300

uucugcgagg gcagagugag aggcgaggcc aucagaauca gaaccaugaa gaugagacag      360

caggccagcu uccugcccgc cacccugacc augaccgugg acaagggcga caacgugaac      420

aucagcuuca agaaggugcu gaucaaggag gaggacgccg ugaucuacaa gaacggcagc      480

uucauccaca gcgugcccag acacgaggug cccgacaucc uggaggugca ccugccccac      540

gcccagcccc aggacgccgg cguguacagc gccagauaca ucggcggcaa ccuguucacc      600

agcgccuuca ccagacugau cgugagaaga ugcgaggccc agaagugggg ccccgagugc      660

aaccaccugu gcaccgccug caugaacaac ggcgugugcc acgaggacac cggcgagugc      720

aucugccccc ccggcuucau gggcagaacc ugcgagaagg ccugcgagcu gcacaccuuc      780

ggcagaaccu gcaaggagag augcagcggc caggagggcu gcaagagcua cguguucugc      840

cugcccgacc ccuacggcug cagcugcgcc accggcugga agggccugca gugcaacgag      900

gccugccacc ccggcuucua cggccccgac ugcaagcuga gaugcagcug caacaacggc      960

gagaugugcg acagauucca gggcugccug ugcagccccg gcuggcaggg ccugcagugc     1020

gagagagagg gcauccagag aaugaccccc aagaucgugg accugcccga ccacaucgag     1080

gugaacagcg gcaaguucaa ccccaucugc aaggccagcg gcuggccccu gcccaccaac     1140

gaggagauga cccuggugaa gcccgacggc accgugcugc accccaagga cuucaaccac     1200

accgaccacu ucagcguggc caucuucacc auccacagaa uccugccccc cgacagcggc     1260

gugugggugu gcagcgugaa caccguggcc ggcauggugg agaagcccuu caacaucagc     1320

gugaaggugc ugcccaagcc ccugaacgcc cccaacguga ucgacaccgg ccacaacuuc     1380

gccgugauca acaucagcag cgagcccuac uucggcgacg gccccaucaa gagcaagaag     1440

cugcuguaca agcccgugaa ccacuacgag gccuggcagc acauccaggu gaccaacgag     1500

aucgugaccc ugaacuaccu ggagcccaga accgaguacg agcugugcgu gcagcuggug     1560

agaagaggcg agggcggcga gggccacccc ggccccguga gaagauucac caccgccagc     1620

aucggccugc ccccccccag aggccugaac cugcugccca agagccagac cacccugaac     1680

cugaccuggc agcccaucuu ccccagcagc gaggacgacu ucuacgugga gguggagaga     1740

agaagcgugc agaagagcga ccagcagaac aucaaggugc ccggcaaccu gaccagcgug     1800

cugcugaaca accugcaccc cagagagcag uacgugguga gagccagagu gaacaccaag     1860

gcccagggcg aguggagcga ggaccugacc gccuggaccc ugagcgacau ccugcccccc     1920

cagcccgaga acaucaagau cagcaacauc acccacagca gcgccgugau cagcuggacc     1980

auccuggacg gcuacagcau cagcagcauc accaucagau acaaggugca gggcaagaac     2040

gaggaccagc acguggacgu gaagaucaag aacgccacca ucacccagua ccagcugaag     2100

ggccuggagc ccgagaccgc cuaccaggug gacaucuucg ccgagaacaa caucggcagc     2160

agcaaccccg ccuucagcca cgagcuggug acccugcccg agagccaggc ccccgccgac     2220

cugggcggcg gcaagaugcu gcugaucgcc auccugggca gcgccggcau gaccugccug     2280

accgugcugc uggccuuccu gaucauccug cagcugaaga gagccaacgu gcagagaaga     2340

auggcccagg ccuuccagaa cgugagagag gagcccgccg ugcaguucaa cagcggcacc     2400

cuggcccuga acagaaaggu gaagaacaac cccgacccca ccaucuaccc cgugcuggac     2460

uggaacgaca ucaaguucca ggacgugauc ggcgagggca acuucggcca ggugcugaag     2520

gccagaauca agaaggacgg ccugagaaug gacgccgcca ucaagagaau gaaggaguac     2580

gccagcaagg acgaccacag agacuucgcc ggcgagcugg aggugcugug caagcugggc     2640

caccacccca acaucaucaa ccugcugggc gccugcgagc acagaggcua ccuguaccug     2700

gccaucgagu acgcccccca cggcaaccug cuggacuucc ugagaaagag cagagugcug     2760

gagaccgacc ccgccuucgc caucgccaac agcaccgcca gcacccugag cagccagcag     2820

cugcugcacu ucgccgccga cguggccaga ggcauggacu accugagcca gaagcaguuc     2880

auccacagag accuggccgc cagaaacauc cuggugggcg agaacuacgu ggccaagauc     2940

gccgacuucg gccugagcag aggccaggag guguacguga agaagaccau gggcagacug     3000

cccgugagau ggauggccau cgagagccug aacuacagcg uguacaccac caacagcgac     3060

guguggagcu acggcgugcu gcugugggag aucgugagcc ugggcggcac ccccuacugc     3120

ggcaugaccu gcgccgagcu guacgagaag cugccccagg gcuacagacu ggagaagccc     3180

cugaacugcg acgacgaggu guacgaccug augagacagu gcuggagaga gaagcccuac     3240

gagagaccca gcuucgccca gauccuggug agccugaaca gaaugcugga ggagagaaag     3300

accuacguga acaccacccu guacgagaag uucaccuacg ccggcaucga cugcagcgcc     3360

gaggaggccg ccuga                                                      3375


<210>  3645
<211>  3375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIE2__Homo_sapiens__CCDS6519.1

<400>  3645
auggacagcc uggccucccu cgugcugugc ggcgucucuc uucugcucag cgggaccguu       60

gagggagcua uggaucugau ccuuauuaac ucccugcccc ucgugucuga cgccgaaaca      120

agccugacgu guaucgcguc cggcuggaga ccucacgagc cgauuaccau cgggcgggau      180

uucgaagcuc ugaugaauca gcaucaagac ccccucgagg ugacacagga ugucacccgc      240

gaaugggcca agaaaguggu uuggaagaga gagaaagccu cuaagauuaa cggagcuuac      300

uuuugcgagg gccgggugcg cggggaagcc aucagaaucc ggacaaugaa aaugcgccag      360

caggcuagcu uccugccugc cacccuuaca augaccgucg acaagggaga uaaugugaac      420

auuuccuuua agaaaguucu gaucaaggag gaagacgcgg ugauuuauaa aaauggcagc      480

uucauccacu cuguccccag acaugaggug ccugauauuc ucgaggugca ucugccccac      540

gcccaaccuc aggacgcugg cgucuacucc gcccgguaua ucgggggaaa ccuuuuuacg      600

agcgcuuuca cccgccugau uguuagacgg ugugaagccc agaagugggg cccggagugc      660

aaucaccucu guacagcgug caugaacaau gggguguguc acgaagauac cggagagugc      720

aucugucccc cuggcuuuau ggggcgcaca ugcgaaaaag ccugugagcu gcauaccuuc      780

ggaagaacgu gcaaggagcg gugcucuggc caggaaggcu guaaguccua cguguuuugc      840

cugcccgacc cuuaugggug uagcugcgcu acaggaugga aaggccucca auguaacgag      900

gccugccacc ccggguucua cggaccggau uguaagcugc gcugcucuug uaauaacggc      960

gaaaugugcg acagauuuca ggggugucuu ugcuccccug gauggcaggg ccugcagugc     1020

gagcgggaag gcauccaaag aaugaccccc aaaauugucg accucccuga ucauaucgag     1080

gugaauagcg ggaaguucaa ccccauuugu aaggcuuccg gauggccccu gccuacaaau     1140

gaggaaauga cccuuguuaa accggacggc accgugcugc accccaaaga uuuuaaccac     1200

acagaccauu ucucugucgc caucuucacg auucaccgca uccucccucc cgauagcggg     1260

guguggguuu gcuccgugaa caccgucgcc ggaauggugg agaagccuuu uaauaucagc     1320

gucaaggugc ugcccaaacc gcugaacgcu ccuaauguua uugacacagg ccauaacuuc     1380

gcggugauca auauuucuuc cgaacccuau uuuggggaug gcccuaucaa gagcaaaaag     1440

cuccuguaca aacccgucaa ccacuacgag gccuggcagc auauucaggu gaccaaugaa     1500

aucguuacac uuaacuaucu ggagccucgg accgaguacg aacucugugu gcaacugguc     1560

agacgcggag agggcgggga aggacacccc ggcccggugc ggagauucac gacagcuucu     1620

aucgggcuuc cuccuccccg cggacugaau cuccugccca agagccagac cacccugaac     1680

cucacauggc agccgauuuu ucccuccucu gaggacgauu ucuaugugga gguugaacgg     1740

agaagcgucc agaaguccga ccaacagaau aucaaagugc cuggcaaccu gaccagcgug     1800

cuucugaaua accuccaccc ccgcgagcag uacgucgugc gggccagagu uaauacaaag     1860

gcccaggggg aauggucuga ggaucugacg gcuuggaccc uguccgacau ucuuccuccc     1920

caaccugaaa acaucaaaau uagcaacauc acacauucuu ccgccgugau uagcuggacc     1980

auccucgacg gcuauuccau cucuagcauu acaauccgcu acaaggucca gggcaaaaau     2040

gaggaucagc acguggacgu uaagauuaag aacgcgacca ucacgcagua ucaacugaaa     2100

ggacuggagc ccgaaaccgc uuaccaggug gauauuuuug ccgagaauaa caucgggucc     2160

ucuaauccgg ccuucagcca ugaacucguc acacugccug agucccaggc ucccgccgac     2220

cuuggaggcg ggaagaugcu gcucaucgcu auucugggaa gcgccggcau gaccugccug     2280

acagugcuuc ucgcguuucu gaucauucug cagcucaaac gggccaacgu ucaaagacgg     2340

auggcucagg ccuuccagaa ugugcgcgag gaaccugcug uccaauuuaa cucugggacc     2400

cuggcccuua auagaaaggu gaaaaacaau cccgauccga cgaucuaccc ugugcuggac     2460

uggaacgaua uuaaguucca ggacgucauc ggcgagggaa auuuuggcca gguucucaag     2520

gcgcggauca aaaaggaugg gcugagaaug gacgccgcua uuaaacgcau gaaggaauau     2580

gccuccaaag augaccaccg ggauuucgcu ggagagcugg aagugcuuug uaagcucggc     2640

caccauccca acaucauuaa ucugcugggg gccugcgagc acagaggaua ccucuaucug     2700

gccaucgaau acgcuccuca uggcaaccuu cuggacuucc uccgcaaaag cagagugcug     2760

gagacagacc ccgcguuugc cauugcuaac ucuaccgccu ccacacugag cucucagcaa     2820

cuucuccacu ucgccgcuga ugucgcccgg gggauggacu aucugagcca gaagcaguuu     2880

auccaucgcg aucuggcggc uagaaauauc cucgugggcg agaacuacgu ugccaagauu     2940

gccgacuucg gacugucccg gggccaggaa guguauguca aaaagaccau ggggcgccuu     3000

cccgugagau ggauggcuau cgagagccug aauuacucug uuuacaccac aaacuccgau     3060

guguggagcu auggaguccu ccugugggaa auuguguccc ugggcgggac gccuuacugu     3120

ggaaugaccu gcgccgagcu uuaugagaaa cugccgcaag gcuaccggcu cgaaaagccc     3180

cugaauugug acgaugaggu uuaugaccuc augcgccagu gcuggagaga aaaaccuuac     3240

gagcggcccu cuuuugcgca gauccuggug agccuuaacc gcaugcugga agagagaaag     3300

acauauguca auaccacacu cuacgagaag uucaccuacg cuggcauuga uuguuccgcc     3360

gaagaggccg cuuga                                                      3375


<210>  3646
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TKTL1__Homo_sapiens__P51854

<400>  3646

Met Ala Asp Ala Glu Ala Arg Ala Glu Phe Pro Glu Glu Ala Arg Pro 
1               5                   10                  15      


Asp Arg Gly Thr Leu Gln Val Leu Gln Asp Met Ala Ser Arg Leu Arg 
            20                  25                  30          


Ile His Ser Ile Arg Ala Thr Cys Ser Thr Ser Ser Gly His Pro Thr 
        35                  40                  45              


Ser Cys Ser Ser Ser Ser Glu Ile Met Ser Val Leu Phe Phe Tyr Ile 
    50                  55                  60                  


Met Arg Tyr Lys Gln Ser Asp Pro Glu Asn Pro Asp Asn Asp Arg Phe 
65                  70                  75                  80  


Val Leu Ala Lys Arg Leu Ser Phe Val Asp Val Ala Thr Gly Trp Leu 
                85                  90                  95      


Gly Gln Gly Leu Gly Val Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr 
            100                 105                 110         


Phe Asp Arg Ala Ser Tyr Arg Val Phe Cys Leu Met Ser Asp Gly Glu 
        115                 120                 125             


Ser Ser Glu Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Tyr Tyr 
    130                 135                 140                 


Ser Leu Asp Asn Leu Val Ala Ile Phe Asp Val Asn Arg Leu Gly His 
145                 150                 155                 160 


Ser Gly Ala Leu Pro Ala Glu His Cys Ile Asn Ile Tyr Gln Arg Arg 
                165                 170                 175     


Cys Glu Ala Phe Gly Trp Asn Thr Tyr Val Val Asp Gly Arg Asp Val 
            180                 185                 190         


Glu Ala Leu Cys Gln Val Phe Trp Gln Ala Ser Gln Val Lys His Lys 
        195                 200                 205             


Pro Thr Ala Val Val Ala Lys Thr Phe Lys Gly Arg Gly Thr Pro Ser 
    210                 215                 220                 


Ile Glu Asp Ala Glu Ser Trp His Ala Lys Pro Met Pro Arg Glu Arg 
225                 230                 235                 240 


Ala Asp Ala Ile Ile Lys Leu Ile Glu Ser Gln Ile Gln Thr Ser Arg 
                245                 250                 255     


Asn Leu Asp Pro Gln Pro Pro Ile Glu Asp Ser Pro Glu Val Asn Ile 
            260                 265                 270         


Thr Asp Val Arg Met Thr Ser Pro Pro Asp Tyr Arg Val Gly Asp Lys 
        275                 280                 285             


Ile Ala Thr Arg Lys Ala Cys Gly Leu Ala Leu Ala Lys Leu Gly Tyr 
    290                 295                 300                 


Ala Asn Asn Arg Val Val Val Leu Asp Gly Asp Thr Arg Tyr Ser Thr 
305                 310                 315                 320 


Phe Ser Glu Ile Phe Asn Lys Glu Tyr Pro Glu Arg Phe Ile Glu Cys 
                325                 330                 335     


Phe Met Ala Glu Gln Asn Met Val Ser Val Ala Leu Gly Cys Ala Ser 
            340                 345                 350         


Arg Gly Arg Thr Ile Ala Phe Ala Ser Thr Phe Ala Ala Phe Leu Thr 
        355                 360                 365             


Arg Ala Phe Asp His Ile Arg Ile Gly Gly Leu Ala Glu Ser Asn Ile 
    370                 375                 380                 


Asn Ile Ile Gly Ser His Cys Gly Val Ser Val Gly Asp Asp Gly Ala 
385                 390                 395                 400 


Ser Gln Met Ala Leu Glu Asp Ile Ala Met Phe Arg Thr Ile Pro Lys 
                405                 410                 415     


Cys Thr Ile Phe Tyr Pro Thr Asp Ala Val Ser Thr Glu His Ala Val 
            420                 425                 430         


Ala Leu Ala Ala Asn Ala Lys Gly Met Cys Phe Ile Arg Thr Thr Arg 
        435                 440                 445             


Pro Glu Thr Met Val Ile Tyr Thr Pro Gln Glu Arg Phe Glu Ile Gly 
    450                 455                 460                 


Gln Ala Lys Val Leu Arg His Cys Val Ser Asp Lys Val Thr Val Ile 
465                 470                 475                 480 


Gly Ala Gly Ile Thr Val Tyr Glu Ala Leu Ala Ala Ala Asp Glu Leu 
                485                 490                 495     


Ser Lys Gln Asp Ile Phe Ile Arg Val Ile Asp Leu Phe Thr Ile Lys 
            500                 505                 510         


Pro Leu Asp Val Ala Thr Ile Val Ser Ser Ala Lys Ala Thr Glu Gly 
        515                 520                 525             


Arg Ile Ile Thr Val Glu Asp His Tyr Pro Gln Gly Gly Ile Gly Glu 
    530                 535                 540                 


Ala Val Cys Ala Ala Val Ser Met Asp Pro Asp Ile Gln Val His Ser 
545                 550                 555                 560 


Leu Ala Val Ser Gly Val Pro Gln Ser Gly Lys Ser Glu Glu Leu Leu 
                565                 570                 575     


Asp Met Tyr Gly Ile Ser Ala Arg His Ile Ile Val Ala Val Lys Cys 
            580                 585                 590         


Met Leu Leu Asn 
        595     


<210>  3647
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TKTL1__Homo_sapiens__BAF84950

<400>  3647
auggcggaug cugaggcgag ggcugaguuc ccggaggagg ccagaccuga caggggcacc       60

uugcaggugu ugcaagauau ggccagccgc uugcgaaucc auuccaucag ggccacaugc      120

uccacgagcu ccggccaccc uacaucaugu agcaguucuu cugagaucau gucugugcug      180

uucuucuaca ucaugaggua caagcaguca gauccagaga auccggacaa cgaccgauuu      240

guccucgcaa agagacuguc guuuguggau guggcaacag gauggcucgg acaaggacug      300

ggaguugcau guggaauggc auauacuggc aaguacuucg acagggccag cuaccgggug      360

uucugccuca ugagugaugg cgaguccuca gaaggcucug ucugggaggc aauggccuuu      420

gcuuccuacu acagucugga caaucuugug gcaaucuuug augugaaccg ccugggacac      480

aguggugcau ugcccgccga gcacugcaua aacaucuauc agaggcgcug cgaagccuuu      540

ggguggaaca cuuauguggu ggacggccgg gacguggagg cacugugcca gguauucugg      600

caggcuucuc aggugaagca caagcccacu gcuguggugg ccaagaccuu caagggccgg      660

ggcaccccaa guauugagga ugcagaaagu uggcaugcaa agccaaugcc gagagaaaga      720

gcagaugcca uuaucaaauu aauugagagc cagauacaga ccagcaggaa ucuugaccca      780

cagcccccca uugaggacuc accugaaguc aacaucacag auguaaggau gaccucucca      840

ccugauuaca gaguugguga caagauagcu acucggaaag caugcggucu ggcucuggcu      900

aagcugggcu acgcgaacaa cagagucguu gugcuggaug gugacaccag guacucuacu      960

uucucugaga uauucaacaa ggaguacccu gagcgcuuca ucgagugcuu uauggcugaa     1020

caaaacaugg ugagcguggc ucugggcugu gccucccgug gacggaccau ugcuuuugcu     1080

agcaccuuug cugccuuucu gacucgagca uuugaucaca uccggauagg aggccucgcu     1140

gagagcaaca ucaacauuau ugguucccac ugugggguau cuguugguga cgauggugcu     1200

ucccagaugg cccuggagga uauagccaug uuccgaacca uucccaagug cacgaucuuc     1260

uacccaacug augccgucuc cacggagcau gcuguugcuc uggcagccaa ugccaagggg     1320

augugcuuca uucggaccac ccgaccagaa acuaugguua uuuacacccc acaagaacgc     1380

uuugagaucg gacaggccaa gguccuccgc cacuguguca gugacaaggu cacaguuauu     1440

ggagcuggaa uuacugugua ugaagccuua gcagcugcug augagcuuuc gaaacaagau     1500

auuuuuaucc gugucaucga ccuguuuacc auuaaaccuc uggaugucgc caccaucguc     1560

uccagugcaa aagccacaga gggccggauc auuacagugg aggaucacua cccgcaaggu     1620

ggcaucgggg aagcugucug cgcagccguc uccauggauc cugacauuca gguucauucg     1680

cuggcagugu cgggagugcc ccagaguggg aaguccgagg aauugcugga uauguaugga     1740

auuagugcca gacauaucau aguggccgug aaaugcaugu ugcugaacua a              1791


<210>  3648
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TKTL1__Homo_sapiens__BAF84950

<400>  3648
auggccgacg ccgaggcgcg cgccgaguuc cccgaggagg cccggccgga ccgcggcacc       60

cuccaggugc ugcaggacau ggccagccgg cugcgcaucc acuccauccg ggcgaccugc      120

agcacgucca gcgggcaccc caccuccugc agcuccagcu ccgagaucau gagcguccug      180

uucuucuaca ucaugcgcua caagcagucc gaccccgaga accccgacaa cgaccgguuc      240

gugcucgcca agcgccugag cuucguggac gucgccaccg gcuggcuggg gcagggccuc      300

gggguggccu gcggcauggc cuacaccggc aaguacuucg accgggcguc cuaccgcgug      360

uucugccuga ugagcgacgg ggaguccagc gagggcuccg ucugggaggc cauggccuuc      420

gccagcuacu acucccugga caaccucgug gccaucuucg acgugaaccg gcuggggcac      480

agcggcgcgc ugccggccga gcacugcauc aacaucuacc agcgccggug cgaggccuuc      540

ggguggaaca cguacgucgu ggacggccgc gacguggagg cccucugcca ggucuucugg      600

caggccagcc aggugaagca caagcccacc gcgguggucg ccaagaccuu caagggccgg      660

gggacccccu ccaucgagga cgccgagagc uggcacgcca agcccaugcc gcgcgagcgg      720

gccgacgcga ucaucaagcu gaucgagucc cagauccaga cgagccgcaa ccuggacccc      780

cagccgccca ucgaggacuc ccccgaggug aacaucaccg acgugcggau gaccagcccg      840

cccgacuacc gcgucggcga caagaucgcc acccggaagg ccugcgggcu cgcccuggcc      900

aagcugggcu acgcgaacaa ccgcguggug guccucgacg gcgacacgcg cuacuccacc      960

uucagcgaga ucuucaacaa ggaguacccc gagcgguuca ucgagugcuu cauggccgag     1020

cagaacaugg uguccguggc ccuggggugc gccagccgcg gccggaccau cgcguucgcc     1080

uccaccuucg ccgccuuccu gacgcgcgcc uucgaccaca uccggaucgg gggccucgcg     1140

gagagcaaca ucaacaucau cgggucccac ugcggcguca gcgugggcga cgacggggcc     1200

ucccagaugg cccuggagga caucgccaug uuccgcacca uccccaagug caccaucuuc     1260

uaccccaccg acgccgucag cacggagcac gcgguggccc uggccgccaa cgccaagggc     1320

augugcuuca uccggaccac ccgccccgag accaugguga ucuacacgcc ccaggagcgg     1380

uucgagaucg ggcaggcgaa gguccuccgc cacugcgugu ccgacaaggu gaccgucauc     1440

ggcgccggga ucaccgugua cgaggcccug gccgcggccg acgagcugag caagcaggac     1500

aucuucaucc gggugaucga ccucuucacc aucaagccgc uggacgucgc cacgaucgug     1560

uccagcgcca aggccaccga gggccgcauc aucaccgugg aggaccacua cccccagggc     1620

gggaucggcg aggcggucug cgccgccgug agcauggacc ccgacaucca ggugcacucc     1680

cuggccguca gcggggugcc ccaguccggc aagagcgagg agcuccugga cauguacggg     1740

aucuccgccc ggcacaucau cguggcgguc aagugcaugc ugcucaacug a              1791


<210>  3649
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TKTL1__Homo_sapiens__BAF84950

<400>  3649
auggccgacg ccgaggcccg cgccgaguuc cccgaggagg cccgccccga ccgcggcacc       60

cuccaggucc uccaggacau ggccucccgc cuccgcaucc acuccauccg cgccaccugc      120

uccaccuccu ccggccaccc caccuccugc uccuccuccu ccgagaucau guccguccuc      180

uucuucuaca ucaugcgcua caagcagucc gaccccgaga accccgacaa cgaccgcuuc      240

guccucgcca agcgccucuc cuucgucgac gucgccaccg gcuggcucgg ccagggccuc      300

ggcgucgccu gcggcauggc cuacaccggc aaguacuucg accgcgccuc cuaccgcguc      360

uucugccuca uguccgacgg cgaguccucc gagggcuccg ucugggaggc cauggccuuc      420

gccuccuacu acucccucga caaccucguc gccaucuucg acgucaaccg ccucggccac      480

uccggcgccc uccccgccga gcacugcauc aacaucuacc agcgccgcug cgaggccuuc      540

ggcuggaaca ccuacgucgu cgacggccgc gacgucgagg cccucugcca ggucuucugg      600

caggccuccc aggucaagca caagcccacc gccgucgucg ccaagaccuu caagggccgc      660

ggcacccccu ccaucgagga cgccgagucc uggcacgcca agcccaugcc ccgcgagcgc      720

gccgacgcca ucaucaagcu caucgagucc cagauccaga ccucccgcaa ccucgacccc      780

cagcccccca ucgaggacuc ccccgagguc aacaucaccg acguccgcau gaccuccccc      840

cccgacuacc gcgucggcga caagaucgcc acccgcaagg ccugcggccu cgcccucgcc      900

aagcucggcu acgccaacaa ccgcgucguc guccucgacg gcgacacccg cuacuccacc      960

uucuccgaga ucuucaacaa ggaguacccc gagcgcuuca ucgagugcuu cauggccgag     1020

cagaacaugg ucuccgucgc ccucggcugc gccucccgcg gccgcaccau cgccuucgcc     1080

uccaccuucg ccgccuuccu cacccgcgcc uucgaccaca uccgcaucgg cggccucgcc     1140

gaguccaaca ucaacaucau cggcucccac ugcggcgucu ccgucggcga cgacggcgcc     1200

ucccagaugg cccucgagga caucgccaug uuccgcacca uccccaagug caccaucuuc     1260

uaccccaccg acgccgucuc caccgagcac gccgucgccc ucgccgccaa cgccaagggc     1320

augugcuuca uccgcaccac ccgccccgag accaugguca ucuacacccc ccaggagcgc     1380

uucgagaucg gccaggccaa gguccuccgc cacugcgucu ccgacaaggu caccgucauc     1440

ggcgccggca ucaccgucua cgaggcccuc gccgccgccg acgagcucuc caagcaggac     1500

aucuucaucc gcgucaucga ccucuucacc aucaagcccc ucgacgucgc caccaucguc     1560

uccuccgcca aggccaccga gggccgcauc aucaccgucg aggaccacua cccccagggc     1620

ggcaucggcg aggccgucug cgccgccguc uccauggacc ccgacaucca gguccacucc     1680

cucgccgucu ccggcguccc ccaguccggc aaguccgagg agcuccucga cauguacggc     1740

aucuccgccc gccacaucau cgucgccguc aagugcaugc uccucaacug a              1791


<210>  3650
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TKTL1__Homo_sapiens__BAF84950

<400>  3650
auggccgacg cugaggcaag agccgaguuc cccgaggaag cgaggccuga ucggggcacc       60

cuccaggugc ugcaagacau ggcuagccgc cuucgaaucc acuccauucg ugccacaugc      120

ucuacuucaa gugggcaucc aacgagcugu uccucuucgu cagagauaau gagcguccug      180

uuuuucuaca ucaugagaua uaagcagagu gauccggaaa accccgacaa ugauagguuu      240

guuuuggcaa aacgguuauc cuucguggac guagccaccg gauggcuggg ucagggccua      300

gggguggcuu gcggaauggc auacacaggc aaguauuuug aucgcgccuc uuacagaguc      360

uucugucuca ugagcgacgg ugaguccuca gaggggagug ugugggaagc uauggccuuu      420

gcgagcuauu acucucugga uaaccuuguu gcaauuuucg acgugaauag gcugggacac      480

uccggcgccu ugccugcuga gcauugcauc aacauuuauc agcggcgcug ugaagccuuu      540

ggcuggaaua cuuacgucgu ggaugggcga gacguagagg cacucugcca aguuuucugg      600

caggcuucac aggugaaaca caagccaacc gccgucgugg cgaaaacauu uaagggaaga      660

gguaccccca gcaucgagga ugccgaaagu uggcaugcaa agccuaugcc aagggagcgg      720

gcugacgcca uaaucaaacu gauugaaucu cagauccaaa cuucccguaa ccuggacccc      780

cagccuccaa uugaggauag cccggaagug aauaucacag acguccgcau gaccucgccc      840

ccugauuaca gaguuggcga caagauagcu acgaggaaag ccugugggcu cgcauuagcc      900

aagcugggau augcuaacaa ucggguggua gugcuugaug gcgacacucg auacucuacc      960

uucuccgaga uuuuuaacaa agaguaucca gaacgcuuca ucgagugcuu cauggcggaa     1020

cagaauaugg ucucaguggc auuggguugu gccaguagag ggaggacaau ugcuuuugcc     1080

agcacuuucg cagccuuucu gacccgggcu uucgaucaca uccgcaucgg aggccuagcc     1140

gaguccaaca uuaauauaau cggcucucac ugcgggguua gcgugggaga cgauggugca     1200

ucacagaugg cgcucgaaga cauugcuaug uuuagaacaa uccccaagug uaccauauuc     1260

uacccuacgg augccgucag uacugagcau gcaguggccc uggcugccaa cgcaaagggc     1320

augugcuuua uuaggacaac ccguccagag acuaugguaa ucuauacacc ccaagaacgg     1380

uucgagaucg ggcaggcuaa aguucuucga cacugcgugu ccgacaaggu caccgugauu     1440

ggagccggca ucacggucua cgaagcgcug gccgcugcag acgaguugag caaacaggau     1500

auuuuuauaa gagugaucga ccucuucacc auuaagccgc uggauguugc cacaaucgug     1560

ucuucagcua aagccacuga agguaggauc auuaccguag aggaccauua uccucaaggg     1620

ggcauaggag aggcagucug ugcggccgug aguauggauc ccgacaucca gguucacagc     1680

uuagcugugu ccggcguccc acagucuggg aagucggaag aacugcucga uauguacgga     1740

auuagcgccc gccacaucau uguggcagua aaaugcaugc uucugaauug a              1791


<210>  3651
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TKTL1__Homo_sapiens__BAF84950

<400>  3651
auggccgacg ccgaggccag agccgaguuc cccgaggagg ccagacccga cagaggcacc       60

cugcaggugc ugcaggacau ggccagcaga cugagaaucc acagcaucag agccaccugc      120

agcaccagca gcggccaccc caccagcugc agcagcagca gcgagaucau gagcgugcug      180

uucuucuaca ucaugagaua caagcagagc gaccccgaga accccgacaa cgacagauuc      240

gugcuggcca agagacugag cuucguggac guggccaccg gcuggcuggg ccagggccug      300

ggcguggccu gcggcauggc cuacaccggc aaguacuucg acagagccag cuacagagug      360

uucugccuga ugagcgacgg cgagagcagc gagggcagcg ugugggaggc cauggccuuc      420

gccagcuacu acagccugga caaccuggug gccaucuucg acgugaacag acugggccac      480

agcggcgccc ugcccgccga gcacugcauc aacaucuacc agagaagaug cgaggccuuc      540

ggcuggaaca ccuacguggu ggacggcaga gacguggagg cccugugcca gguguucugg      600

caggccagcc aggugaagca caagcccacc gccguggugg ccaagaccuu caagggcaga      660

ggcaccccca gcaucgagga cgccgagagc uggcacgcca agcccaugcc cagagagaga      720

gccgacgcca ucaucaagcu gaucgagagc cagauccaga ccagcagaaa ccuggacccc      780

cagcccccca ucgaggacag ccccgaggug aacaucaccg acgugagaau gaccagcccc      840

cccgacuaca gagugggcga caagaucgcc accagaaagg ccugcggccu ggcccuggcc      900

aagcugggcu acgccaacaa cagaguggug gugcuggacg gcgacaccag auacagcacc      960

uucagcgaga ucuucaacaa ggaguacccc gagagauuca ucgagugcuu cauggccgag     1020

cagaacaugg ugagcguggc ccugggcugc gccagcagag gcagaaccau cgccuucgcc     1080

agcaccuucg ccgccuuccu gaccagagcc uucgaccaca ucagaaucgg cggccuggcc     1140

gagagcaaca ucaacaucau cggcagccac ugcggcguga gcgugggcga cgacggcgcc     1200

agccagaugg cccuggagga caucgccaug uucagaacca uccccaagug caccaucuuc     1260

uaccccaccg acgccgugag caccgagcac gccguggccc uggccgccaa cgccaagggc     1320

augugcuuca ucagaaccac cagacccgag accaugguga ucuacacccc ccaggagaga     1380

uucgagaucg gccaggccaa ggugcugaga cacugcguga gcgacaaggu gaccgugauc     1440

ggcgccggca ucaccgugua cgaggcccug gccgccgccg acgagcugag caagcaggac     1500

aucuucauca gagugaucga ccuguucacc aucaagcccc uggacguggc caccaucgug     1560

agcagcgcca aggccaccga gggcagaauc aucaccgugg aggaccacua cccccagggc     1620

ggcaucggcg aggccgugug cgccgccgug agcauggacc ccgacaucca ggugcacagc     1680

cuggccguga gcggcgugcc ccagagcggc aagagcgagg agcugcugga cauguacggc     1740

aucagcgcca gacacaucau cguggccgug aagugcaugc ugcugaacug a              1791


<210>  3652
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TKTL1__Homo_sapiens__BAF84950

<400>  3652
auggccgacg cugaggccag agcggaauuu cccgaggaag cucggccuga ucgcggcacc       60

cuucaggugc uccaagacau ggccagcaga cugcggaucc acuccauucg cgccacaugc      120

ucuacgagcu ccgggcaucc gaccucuugu agcuccucua gcgagaucau guccguccuu      180

uucuucuaca uuaugagaua uaagcagagc gaucccgaaa acccugacaa ugaucgguuu      240

guucuggcua aacgccucuc uuucguggac guggccacag gauggcuggg ccaggggcuu      300

ggagucgcuu gcggcauggc cuacaccggg aaguauuuug auagagcguc cuaccgggug      360

uucugucuga ugagcgacgg agagucuucc gagggcagcg uuugggaagc cauggcuuuu      420

gccucuuauu acucccucga uaaccuggug gcuaucuucg acgucaaucg ccugggccac      480

agcggggccc uccccgcgga gcauugcauu aacaucuauc agagacggug ugaagccuuu      540

ggauggaaua cauacguggu ugauggccgc gacguggagg cucugugcca agucuucugg      600

caggccuccc aggugaaaca caagccuacc gcuguggucg ccaaaacauu uaaggggaga      660

ggaacccccu cuaucgagga ugccgaaagc uggcaugcua agccuaugcc gcgggagcgc      720

gcggacgcca uuaucaaacu uauugaaucc cagauccaaa cgagcagaaa ccuggacccc      780

cagccuccca uugaggauuc uccugaaguu aauaucaccg acgugcggau gacauccccg      840

cccgauuaca gagugggcga caagauugcu acccgcaaag ccugugggcu cgcccuggcu      900

aagcugggau augccaacaa ucgggucgug guucuggaug gcgacacaag auacagcacc      960

uucucugaga ucuuuaacaa agaguauccu gaacgcuuca ucgagugcuu cauggcggaa     1020

cagaauaugg ugagcgucgc ucucggcugu gccucccggg ggagaacgau ugccuuugcu     1080

ucuacauucg ccgcuuuucu gacccgcgcc uucgaucaca uccggauugg aggccuggcg     1140

gagagcaaca ucaauauuau cgggucccac ugcggaguga gcguuggcga cgauggggcc     1200

ucucagaugg cucucgaaga caucgccaug uuuagaacaa uucccaagug uaccaucuuc     1260

uacccuaccg augcuguguc cacagagcau gccgucgcgc uggccgcuaa cgccaaggga     1320

augugcuuua uucgcacgac ccggcccgag acaaugguga ucuauacacc ccaagaaaga     1380

uucgagauug gccaggcuaa aguccuucgc cacugcguga gcgacaaggu uaccgugauc     1440

ggcgccggga ucaccgucua cgaagcccug gcugcggccg acgagcucuc uaaacaggau     1500

auuuuuaucc gggugauuga ccuguucacg aucaagccuc uugauguugc uacaauugug     1560

uccagcgcca aagccaccga aggaagaauc auuaccgucg aggaccauua uccgcaaggc     1620

gggaucggag aggcugugug ugccgcggug uccauggauc ccgacaucca gguucacucu     1680

cuggcuguca gcggcgugcc ucaguccggg aagucugagg aacuccugga uauguacggc     1740

auuagcgccc ggcacaucau uguggccguc aaaugcaugc ugcucaauug a              1791


<210>  3653
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TPI/m__Homo_sapiens__P60174

<400>  3653

Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr 
1               5                   10                  15      


Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg 
            20                  25                  30          


Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly 
        35                  40                  45              


Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly 
    50                  55                  60                  


Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala 
65                  70                  75                  80  


Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys 
                85                  90                  95      


Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe 
            100                 105                 110         


Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp 
        115                 120                 125             


Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp 
    130                 135                 140                 


Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly 
145                 150                 155                 160 


Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile 
                165                 170                 175     


Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val 
            180                 185                 190         


Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile 
        195                 200                 205             


Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu 
    210                 215                 220                 


Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln 
225                 230                 235                 240 


Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys 
                245                 250                 255     


Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala 
            260                 265                 270         


Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 
        275                 280                 285     


<210>  3654
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TPI/m__Homo_sapiens__EAW88722

<400>  3654
auggcggagg acggcgagga ggcggaguuc cacuucgcgg cgcucuauau aagugggcag       60

uggccgcgac ugcgcgcaga cacugaccuu cagcgccucg gcuccagcgc cauggcgccc      120

uccaggaagu ucuucguugg gggaaacugg aagaugaacg ggcggaagca gagucugggg      180

gagcucaucg gcacucugaa cgcggccaag gugccggccg acaccgaggu gguuugugcu      240

cccccuacug ccuauaucga cuucgcccgg cagaagcuag aucccaagau ugcuguggcu      300

gcgcagaacu gcuacaaagu gacuaauggg gcuuuuacug gggagaucag cccuggcaug      360

aucaaagacu gcggagccac gugggugguc cuggggcacu cagagagaag gcaugucuuu      420

ggggagucag augagcugau ugggcagaaa guggcccaug cucuggcaga gggacucgga      480

guaaucgccu gcauugggga gaagcuagau gaaagggaag cuggcaucac ugagaagguu      540

guuuucgagc agacaaaggu caucgcagau aacgugaagg acuggagcaa ggucguccug      600

gccuaugagc cugugugggc cauugguacu ggcaagacug caacacccca acaggcccag      660

gaaguacacg agaagcuccg aggauggcug aaguccaacg ucucugaugc gguggcucag      720

agcacccgua ucauuuaugg aggcucugug acuggggcaa ccugcaagga gcuggccagc      780

cagccugaug uggauggcuu ccuugugggu ggugcuuccc ucaagcccga auucguggac      840

aucaucaaug ccaaacaaug a                                                861


<210>  3655
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TPI/m__Homo_sapiens__EAW88722

<400>  3655
auggccgagg acggcgagga ggccgaguuc cacuucgcgg cccuguacau cagcgggcag       60

uggccccgcc uccgggccga caccgaccug cagcgccugg gcuccagcgc cauggccccg      120

ucccggaagu ucuucgucgg gggcaacugg aagaugaacg ggcgcaagca gagccucggc      180

gagcugaucg gcacccugaa cgcggccaag gugcccgccg acacggaggu ggugugcgcc      240

ccgcccaccg cguacaucga cuucgcccgg cagaagcucg accccaagau cgccgucgcc      300

gcccagaacu gcuacaaggu gaccaacggg gcguucaccg gcgagaucuc ccccgggaug      360

aucaaggacu gcggcgccac gugggugguc cuggggcaca gcgagcgccg gcacguguuc      420

ggcgaguccg acgagcugau cggccagaag guggcccacg cccucgccga ggggcugggc      480

gucaucgcgu gcaucgggga gaagcuggac gagcgcgagg ccggcaucac cgagaaggug      540

guguucgagc agaccaaggu caucgccgac aacgugaagg acuggagcaa ggugguccuc      600

gccuacgagc ccgugugggc caucggcacc gggaagacgg cgaccccgca gcaggcccag      660

gaggugcacg agaagcugcg gggcuggcug aaguccaacg ucagcgacgc cguggcccag      720

uccacccgca ucaucuacgg gggcagcgug accggggcca cgugcaagga gcucgcgucc      780

cagcccgacg ucgacggcuu ccuggugggc ggggccagcc ugaagcccga guucguggac      840

aucaucaacg ccaagcagug a                                                861


<210>  3656
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TPI/m__Homo_sapiens__EAW88722

<400>  3656
auggccgagg acggcgagga ggccgaguuc cacuucgccg cccucuacau cuccggccag       60

uggccccgcc uccgcgccga caccgaccuc cagcgccucg gcuccuccgc cauggccccc      120

ucccgcaagu ucuucgucgg cggcaacugg aagaugaacg gccgcaagca gucccucggc      180

gagcucaucg gcacccucaa cgccgccaag guccccgccg acaccgaggu cgucugcgcc      240

ccccccaccg ccuacaucga cuucgcccgc cagaagcucg accccaagau cgccgucgcc      300

gcccagaacu gcuacaaggu caccaacggc gccuucaccg gcgagaucuc ccccggcaug      360

aucaaggacu gcggcgccac cugggucguc cucggccacu ccgagcgccg ccacgucuuc      420

ggcgaguccg acgagcucau cggccagaag gucgcccacg cccucgccga gggccucggc      480

gucaucgccu gcaucggcga gaagcucgac gagcgcgagg ccggcaucac cgagaagguc      540

gucuucgagc agaccaaggu caucgccgac aacgucaagg acugguccaa ggucguccuc      600

gccuacgagc ccgucugggc caucggcacc ggcaagaccg ccacccccca gcaggcccag      660

gagguccacg agaagcuccg cggcuggcuc aaguccaacg ucuccgacgc cgucgcccag      720

uccacccgca ucaucuacgg cggcuccguc accggcgcca ccugcaagga gcucgccucc      780

cagcccgacg ucgacggcuu ccucgucggc ggcgccuccc ucaagcccga guucgucgac      840

aucaucaacg ccaagcagug a                                                861


<210>  3657
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TPI/m__Homo_sapiens__EAW88722

<400>  3657
auggccgagg acggcgaaga ggcugaguuc cacuuugcag cccuguacau cagcgggcag       60

uggcccagac ucagggcgga uaccgaccuu caacggcugg gauccucugc uauggccccu      120

ucacgcaagu ucuuuguggg uggcaacugg aaaaugaaug ggcgaaagca gaguuuggga      180

gaauuaauug gcacacugaa cgcagccaaa gucccagcug auacugaagu ugugugcgca      240

ccgcccacgg ccuauauaga cuucgcucgu cagaagcuag auccuaaaau cgccguagcg      300

gcacagaauu guuacaaggu gaccaacggu gccuuuacag gggagauuag cccaggaaug      360

aucaaggacu gcggcgcuac uugggucgug cucggccauu ccgagagaag gcacguuuuc      420

ggggaaucug augagcugau uggacaaaaa guggcccaug cacuugcuga aggucugggc      480

gucaucgccu guauagggga gaaguuggac gagcgggaag cgggaaucac cgagaaagug      540

guauuugaac agacaaaggu uauugccgau aaugugaaag acuggucgaa ggucgugcuc      600

gcauaugagc ccgugugggc uaucggcacc gguaagacug ccacaccuca gcaggcucaa      660

gaaguccacg agaaacugcg cggguggcug aagucaaacg uuagcgaugc cguggcacag      720

aguaccagaa uuaucuacgg aggcuccgua acgggcgcca cuugcaaaga gcucgcuucu      780

cagccagacg uggauggguu cuuagucgga ggugcgagcc ugaagcccga auuuguggac      840

auaauuaaug caaaacagug a                                                861


<210>  3658
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TPI/m__Homo_sapiens__EAW88722

<400>  3658
auggccgagg acggcgagga ggccgaguuc cacuucgccg cccuguacau cagcggccag       60

uggcccagac ugagagccga caccgaccug cagagacugg gcagcagcgc cauggccccc      120

agcagaaagu ucuucguggg cggcaacugg aagaugaacg gcagaaagca gagccugggc      180

gagcugaucg gcacccugaa cgccgccaag gugcccgccg acaccgaggu ggugugcgcc      240

ccccccaccg ccuacaucga cuucgccaga cagaagcugg accccaagau cgccguggcc      300

gcccagaacu gcuacaaggu gaccaacggc gccuucaccg gcgagaucag ccccggcaug      360

aucaaggacu gcggcgccac cuggguggug cugggccaca gcgagagaag acacguguuc      420

ggcgagagcg acgagcugau cggccagaag guggcccacg cccuggccga gggccugggc      480

gugaucgccu gcaucggcga gaagcuggac gagagagagg ccggcaucac cgagaaggug      540

guguucgagc agaccaaggu gaucgccgac aacgugaagg acuggagcaa gguggugcug      600

gccuacgagc ccgugugggc caucggcacc ggcaagaccg ccacccccca gcaggcccag      660

gaggugcacg agaagcugag aggcuggcug aagagcaacg ugagcgacgc cguggcccag      720

agcaccagaa ucaucuacgg cggcagcgug accggcgcca ccugcaagga gcuggccagc      780

cagcccgacg uggacggcuu ccuggugggc ggcgccagcc ugaagcccga guucguggac      840

aucaucaacg ccaagcagug a                                                861


<210>  3659
<211>  861
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TPI/m__Homo_sapiens__EAW88722

<400>  3659
auggccgagg acggcgaaga ggcugaguuc cacuuugccg cgcuguacau cagcgggcag       60

uggcccagac uccgggcuga uaccgaccug caacgccuug gauccucugc cauggccccu      120

agcagaaagu ucuuuguggg cgggaacugg aaaaugaaug gacggaagca gucccugggc      180

gaacucauug ggacacugaa cgcugccaaa gucccggcug auacggaagu ugugugcgcg      240

cccccuaccg ccuauaucga cuucgcccgc cagaagcugg aucccaaaau ugcuguggcc      300

gcucagaauu guuacaaggu cacaaacgga gccuuuaccg gcgagaucuc uccuggcaug      360

auuaaggacu gcggggcgac augggugguu cugggacaua gcgagagacg gcacguguuc      420

ggcgaauccg augagcucau cgggcaaaaa gucgcccaug cucuggccga aggacugggc      480

gugaucgcuu guauugggga gaagcucgac gagcgcgaag ccggaaucac cgagaaaguu      540

guguuugaac agacaaaggu cauugccgau aaugugaaag acuggucuaa ggugguccug      600

gcuuaugagc ccguuugggc gaucggcacc ggcaagacgg ccaccccuca gcaggcucaa      660

gaagugcacg agaaacuuag aggguggcuu aagagcaacg uguccgaugc cgucgcccag      720

agcacacgga uuaucuacgg aggcucugug accggggcua caugcaaaga gcucgccucc      780

cagccggacg uugauggauu ccuggugggc ggggcgagcc uuaagcccga auuugucgac      840

auuaucaaug cuaaacagug a                                                861


<210>  3660
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRGV11__Homo_sapiens__Q99601

<400>  3660

Met Pro Leu Val Val Ala Val Ile Phe Phe Ser Leu Trp Val Phe Ala 
1               5                   10                  15      


Leu Gly Gln Leu Glu Gln Pro Glu Ile Ser Ile Ser Arg Pro Ala Asn 
            20                  25                  30          


Lys Ser Ala His Ile Ser Trp Lys Ala Ser Ile Gln Gly Phe Ser Ser 
        35                  40                  45              


Lys Ile Ile His Trp Tyr Trp Gln Lys Pro Asn Lys Gly Leu Glu Tyr 
    50                  55                  60                  


Leu Leu His Val Phe Leu Thr Ile Ser Ala Gln Asp Cys Ser Gly Gly 
65                  70                  75                  80  


Lys Thr Lys Lys Leu Glu Val Ser Lys Asn Ala His Thr Ser Thr Ser 
                85                  90                  95      


Thr Leu Lys Ile Lys Phe Leu Glu Lys Glu Asp Glu Val Val Tyr His 
            100                 105                 110         


Cys Ala Cys Trp Ile Arg His 
        115                 


<210>  3661
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRGV11__Homo_sapiens__CAA72108

<400>  3661
augccacugg uaguagcugu uaucuucuuc ucccucuggg uuuuugcacu ugggcaguug       60

gaacaaccug aaauaucuau uuccagacca gcaaauaaga gugcccacau aucuuggaag      120

gcauccaucc aaggcuuuag caguaaaauc auacacuggu acuggcagaa accaaacaaa      180

ggcuuagaau auuuauuaca ugucuucuug acaaucucug cucaagauug cucagguggg      240

aagacuaaga aacuugaggu aaguaaaaau gcucacacuu ccacuuccac uuugaaaaua      300

aaguucuuag agaaagaaga ugagguggug uaccacugug ccugcuggau uaggcac         357


<210>  3662
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRGV11__Homo_sapiens__CAA72108

<400>  3662
augccccugg uggucgccgu gaucuucuuc agccucuggg uguucgcccu gggccagcug       60

gagcagccgg agaucuccau cagccgcccc gcgaacaagu ccgcccacau cagcuggaag      120

gccuccaucc agggguucag cuccaagauc auccacuggu acuggcagaa gcccaacaag      180

ggccucgagu accugcugca cgucuuccuc accaucagcg cccaggacug cuccgggggc      240

aagaccaaga agcuggaggu gagcaagaac gcccacacgu ccaccagcac ccugaagauc      300

aaguuccucg agaaggagga cgaggugguc uaccacugcg cgugcuggau ccggcac         357


<210>  3663
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRGV11__Homo_sapiens__CAA72108

<400>  3663
augccccucg ucgucgccgu caucuucuuc ucccucuggg ucuucgcccu cggccagcuc       60

gagcagcccg agaucuccau cucccgcccc gccaacaagu ccgcccacau cuccuggaag      120

gccuccaucc agggcuucuc cuccaagauc auccacuggu acuggcagaa gcccaacaag      180

ggccucgagu accuccucca cgucuuccuc accaucuccg cccaggacug cuccggcggc      240

aagaccaaga agcucgaggu cuccaagaac gcccacaccu ccaccuccac ccucaagauc      300

aaguuccucg agaaggagga cgaggucguc uaccacugcg ccugcuggau ccgccac         357


<210>  3664
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRGV11__Homo_sapiens__CAA72108

<400>  3664
augccccugg uggucgccgu uaucuucuuu agccucuggg uguucgcucu uggccagcug       60

gagcaaccug aaauuuccau aucuagacca gcaaacaagu cagcccacau caguuggaaa      120

gcgagcauuc agggguuuuc cucuaagauc auucauuggu acuggcagaa accgaauaag      180

ggauuggagu auuuacugca cguauuccua accaucucgg cucaggacug cucagguggc      240

aaaacaaaga agcucgaagu gagcaaaaac gcccauacga guacuuccac ccugaagaua      300

aaauuucuug agaaggaaga ugaggucgug uaccacugug caugcuggau caggcau         357


<210>  3665
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRGV11__Homo_sapiens__CAA72108

<400>  3665
augccccugg ugguggccgu gaucuucuuc agccuguggg uguucgcccu gggccagcug       60

gagcagcccg agaucagcau cagcagaccc gccaacaaga gcgcccacau cagcuggaag      120

gccagcaucc agggcuucag cagcaagauc auccacuggu acuggcagaa gcccaacaag      180

ggccuggagu accugcugca cguguuccug accaucagcg cccaggacug cagcggcggc      240

aagaccaaga agcuggaggu gagcaagaac gcccacacca gcaccagcac ccugaagauc      300

aaguuccugg agaaggagga cgagguggug uaccacugcg ccugcuggau cagacac         357


<210>  3666
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRGV11__Homo_sapiens__CAA72108

<400>  3666
augccccugg uggucgccgu uaucuucuuu agccucuggg uguucgcucu gggccagcuu       60

gagcaaccug aaauuuccau cucuagaccg gccaacaaga gcgcgcacau uuccuggaag      120

gcuucuaucc agggguuuag cuccaaaauu auccauuggu acuggcagaa acccaauaag      180

ggacuggagu aucuccugca cguguuccuu accaucucug cccaggacug cagcggcggg      240

aaaacaaaga agcuggaagu cuccaaaaac gcccauacga gcaccucuac acucaagauu      300

aaauuucugg agaaggaaga ugaggugguu uaccacugug cuugcuggau ccggcau         357


<210>  3667
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__A4D1X2

<400>  3667

Met Leu Ser Leu Leu His Thr Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Val His Ser Ser Arg Gln Phe 
        115                 120                 125             


Glu Pro Ser His Ser Ile Asn Val Tyr 
    130                 135         


<210>  3668
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__EAL23985

<400>  3668
augcugucac ugcuccacac aucaacgcug gcaguccuug gggcucugug uguauauggu       60

gcaggucacc uagagcaacc ucaaauuucc aguacuaaaa cgcugucaaa aacagcccgc      120

cuggaaugug uggugucugg aauaacaauu ucugcaacau cuguauauug guaucgagag      180

agaccuggug aagucauaca guuccuggug uccauuucau augacggcac ugucagaaag      240

gaauccggca uuccgucagg caaauuugag guggauagga uaccugaaac gucuacaucc      300

acucucacca uucacaaugu agagaaacag gacauagcua ccuacuacug ugccuugugg      360

gaggugcaca gcagcagaca guuugagcca ucccauucaa uaaauguuua uuga            414


<210>  3669
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRGV9__Homo_sapiens__EAL23985

<400>  3669
augcugagcc uccugcacac cuccacccug gccgugcucg gcgcccugug cgucuacggg       60

gcgggccacc uggagcagcc ccagaucagc uccacgaaga cccucagcaa gaccgcccgc      120

cuggagugcg ugguguccgg gaucaccauc agcgccacgu ccgucuacug guaccgggag      180

cgcccgggcg aggugaucca guuccuggug agcaucuccu acgacgggac cguccggaag      240

gagagcggca uccccuccgg caaguucgag guggaccgca uccccgagac cagcaccucc      300

acgcucacca uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gagguccaca gcucccggca guucgagccc agccacucca ucaacgugua cuga            414


<210>  3670
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRGV9__Homo_sapiens__EAL23985

<400>  3670
augcucuccc uccuccacac cuccacccuc gccguccucg gcgcccucug cgucuacggc       60

gccggccacc ucgagcagcc ccagaucucc uccaccaaga cccucuccaa gaccgcccgc      120

cucgagugcg ucgucuccgg caucaccauc uccgccaccu ccgucuacug guaccgcgag      180

cgccccggcg aggucaucca guuccucguc uccaucuccu acgacggcac cguccgcaag      240

gaguccggca uccccuccgg caaguucgag gucgaccgca uccccgagac cuccaccucc      300

acccucacca uccacaacgu cgagaagcag gacaucgcca ccuacuacug cgcccucugg      360

gagguccacu ccucccgcca guucgagccc ucccacucca ucaacgucua cuga            414


<210>  3671
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRGV9__Homo_sapiens__EAL23985

<400>  3671
augcugagcc uccuucacac cuccacacug gccguguugg gcgcuuuaug cgucuacggg       60

gcaggacauc uggagcagcc ccaaaucucu ucaacuaaga cgcuaaguaa aaccgccaga      120

cucgaaugug uugugagcgg uauuacaaua uccgcgacuu cuguauauug guacagggag      180

cggccuggcg aagugaucca guuccugguc ucgauuucau augacgggac cgugcgcaag      240

gagagcggaa ucccaagugg caaauuugaa guugaucgua uuccggagac auccaccucu      300

acucuuacaa uccacaacgu ggagaagcag gacauagcua ccuacuauug cgcccugugg      360

gaaguccaua gcucccgaca guucgagccc ucacacagua ucaaugugua cuga            414


<210>  3672
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRGV9__Homo_sapiens__EAL23985

<400>  3672
augcugagcc ugcugcacac cagcacccug gccgugcugg gcgcccugug cguguacggc       60

gccggccacc uggagcagcc ccagaucagc agcaccaaga cccugagcaa gaccgccaga      120

cuggagugcg uggugagcgg caucaccauc agcgccacca gcguguacug guacagagag      180

agacccggcg aggugaucca guuccuggug agcaucagcu acgacggcac cgugagaaag      240

gagagcggca uccccagcgg caaguucgag guggacagaa uccccgagac cagcaccagc      300

acccugacca uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gaggugcaca gcagcagaca guucgagccc agccacagca ucaacgugua cuga            414


<210>  3673
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRGV9__Homo_sapiens__EAL23985

<400>  3673
augcugagcc uccugcacac cuccacacuu gccgugcugg gcgcucucug cgucuacggg       60

gccggacauc uggagcagcc ccaaaucucu agcacgaaga cccuuuccaa aacagcgaga      120

cuggaaugug uugugucugg cauuaccauc agcgcuacau ccguguauug guaccgggag      180

cgcccugggg aagucauuca guuccucgug ucuaucagcu augacggaac cguuagaaag      240

gaguccggca uuccgagcgg gaaauuugaa guggaucgga uccccgagac aucuaccucc      300

acgcugacca uccacaacgu cgagaagcag gacauugcca cauacuauug cgcccugugg      360

gaagugcaua gcucucgcca guucgagccu ucccacagca ucaauguuua cuga            414


<210>  3674
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__Q99603

<400>  3674

Met Leu Ser Leu Leu His Thr Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Val 
        115                 120         


<210>  3675
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__CAA30181

<400>  3675
augcugucac ugcuccacac aucaacgcug gcaguccuug gggcucugug uguauauggu       60

gcaggucacc uagagcaacc ucaaauuucc aguacuaaaa cgcugucaaa aacagcccgc      120

cuggaaugug uggugucugg aauaacaauu ucugcaacau cuguauauug guaucgagag      180

agaccuggug aagucauaca guuccuggug uccauuucau augacggcac ugucagaaag      240

gaauccggca uuccgucagg caaauuugag guggauagga uaccugaaac gucuacaucc      300

acucucacca uucacaaugu agagaaacag gacauagcua ccuacuacug ugccuugugg      360

gaggug                                                                 366


<210>  3676
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRGV9__Homo_sapiens__CAA30181

<400>  3676
augcugagcc uccugcacac cuccacccug gccgugcucg gcgcccugug cgucuacggg       60

gcgggccacc uggagcagcc ccagaucagc uccacgaaga cccucagcaa gaccgcccgc      120

cuggagugcg ugguguccgg gaucaccauc agcgccacgu ccgucuacug guaccgggag      180

cgcccgggcg aggugaucca guuccuggug agcaucuccu acgacgggac cguccggaag      240

gagagcggca uccccuccgg caaguucgag guggaccgca uccccgagac cagcaccucc      300

acgcucacca uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gagguc                                                                 366


<210>  3677
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRGV9__Homo_sapiens__CAA30181

<400>  3677
augcucuccc uccuccacac cuccacccuc gccguccucg gcgcccucug cgucuacggc       60

gccggccacc ucgagcagcc ccagaucucc uccaccaaga cccucuccaa gaccgcccgc      120

cucgagugcg ucgucuccgg caucaccauc uccgccaccu ccgucuacug guaccgcgag      180

cgccccggcg aggucaucca guuccucguc uccaucuccu acgacggcac cguccgcaag      240

gaguccggca uccccuccgg caaguucgag gucgaccgca uccccgagac cuccaccucc      300

acccucacca uccacaacgu cgagaagcag gacaucgcca ccuacuacug cgcccucugg      360

gagguc                                                                 366


<210>  3678
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRGV9__Homo_sapiens__CAA30181

<400>  3678
augcugagcc uccuucacac cuccacacug gccguguugg gcgcuuuaug cgucuacggg       60

gcaggacauc uggagcagcc ccaaaucucu ucaacuaaga cgcuaaguaa aaccgccaga      120

cucgaaugug uugugagcgg uauuacaaua uccgcgacuu cuguauauug guacagggag      180

cggccuggcg aagugaucca guuccugguc ucgauuucau augacgggac cgugcgcaag      240

gagagcggaa ucccaagugg caaauuugaa guugaucgaa ucccggagac auccaccucu      300

acucuuacaa uucacaacgu ggagaagcag gacauagcua ccuacuauug cgcccugugg      360

gaaguc                                                                 366


<210>  3679
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRGV9__Homo_sapiens__CAA30181

<400>  3679
augcugagcc ugcugcacac cagcacccug gccgugcugg gcgcccugug cguguacggc       60

gccggccacc uggagcagcc ccagaucagc agcaccaaga cccugagcaa gaccgccaga      120

cuggagugcg uggugagcgg caucaccauc agcgccacca gcguguacug guacagagag      180

agacccggcg aggugaucca guuccuggug agcaucagcu acgacggcac cgugagaaag      240

gagagcggca uccccagcgg caaguucgag guggacagaa uccccgagac cagcaccagc      300

acccugacca uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gaggug                                                                 366


<210>  3680
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRGV9__Homo_sapiens__CAA30181

<400>  3680
augcugagcc uccugcacac cuccacacuu gccgugcugg gcgcucucug cgucuacggg       60

gccggacauc uggagcagcc ccaaaucucu agcacgaaga cccuuuccaa aacagcgaga      120

cuggaaugug uugugucugg cauuaccauc agcgcuacau ccguguauug guaccgggag      180

cgcccugggg aagucauuca guuccucgug ucuaucagcu augacggaac cguuagaaag      240

gaguccggca uuccgagcgg gaaauuugaa guggaucgga uccccgagac aucuaccucc      300

acgcugacca uccacaacgu cgagaagcag gacauugcca cauacuauug cgcccugugg      360

gaagug                                                                 366


<210>  3681
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__Q99604

<400>  3681

Met Leu Ser Leu Leu His Thr Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Lys Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Val 
        115                 120         


<210>  3682
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRGV9__Homo_sapiens__CAA33345

<400>  3682
augcugucac ugcuccacac aucaacgcug gcaguccuug gggcucugug uguauauggu       60

gcaggucacc uagagcaacc ucaaauuucc aguacuaaaa cgcugucaaa aacagcccgc      120

cuggaaugug uggugucugg aauaaaaauu ucugcaacau cuguauauug guaucgagag      180

agaccuggug aagucauaca guuccuggug uccauuucau augacggcac ugucagaaag      240

gaaucuggca uuccgucagg caaauuugag guggauagga uaccugaaac gucuacaucc      300

acucucacca uucacaaugu agagaaacag gacauagcua ccuacuacug ugccuugugg      360

gaggug                                                                 366


<210>  3683
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRGV9__Homo_sapiens__CAA33345

<400>  3683
augcugagcc uccugcacac cuccacccug gccgugcucg gcgcccugug cgucuacggg       60

gcgggccacc uggagcagcc ccagaucagc uccacgaaga cccucagcaa gaccgcccgc      120

cuggagugcg ugguguccgg gaucaagauc agcgccaccu ccgucuacug guaccgggag      180

cgcccgggcg aggugaucca guuccuggug agcaucuccu acgacgggac gguccggaag      240

gagagcggca uccccuccgg caaguucgag guggaccgca uccccgagac cagcaccucc      300

acccucacga uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gagguc                                                                 366


<210>  3684
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRGV9__Homo_sapiens__CAA33345

<400>  3684
augcucuccc uccuccacac cuccacccuc gccguccucg gcgcccucug cgucuacggc       60

gccggccacc ucgagcagcc ccagaucucc uccaccaaga cccucuccaa gaccgcccgc      120

cucgagugcg ucgucuccgg caucaagauc uccgccaccu ccgucuacug guaccgcgag      180

cgccccggcg aggucaucca guuccucguc uccaucuccu acgacggcac cguccgcaag      240

gaguccggca uccccuccgg caaguucgag gucgaccgca uccccgagac cuccaccucc      300

acccucacca uccacaacgu cgagaagcag gacaucgcca ccuacuacug cgcccucugg      360

gagguc                                                                 366


<210>  3685
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRGV9__Homo_sapiens__CAA33345

<400>  3685
augcugagcc uccuucacac cuccacacug gccguguugg gcgcuuuaug cgucuacggg       60

gcaggacauc uggagcagcc ccaaaucucu ucaacuaaga cgcuaaguaa aaccgccaga      120

cucgaaugug uugugagcgg uauuaagaua uccgcgacau cuguauauug guacagggag      180

cggccuggcg aagugaucca guuccugguc ucgauuucau augacgggac ugugcgcaaa      240

gagagcggaa ucccaagugg caaguuugaa guugaucgaa ucccggagac cuccacaucu      300

acccuuacua uucacaacgu ggagaaacag gacauagcua cauacuauug cgcccugugg      360

gaaguc                                                                 366


<210>  3686
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRGV9__Homo_sapiens__CAA33345

<400>  3686
augcugagcc ugcugcacac cagcacccug gccgugcugg gcgcccugug cguguacggc       60

gccggccacc uggagcagcc ccagaucagc agcaccaaga cccugagcaa gaccgccaga      120

cuggagugcg uggugagcgg caucaagauc agcgccacca gcguguacug guacagagag      180

agacccggcg aggugaucca guuccuggug agcaucagcu acgacggcac cgugagaaag      240

gagagcggca uccccagcgg caaguucgag guggacagaa uccccgagac cagcaccagc      300

acccugacca uccacaacgu ggagaagcag gacaucgcca ccuacuacug cgcccugugg      360

gaggug                                                                 366


<210>  3687
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRGV9__Homo_sapiens__CAA33345

<400>  3687
augcugagcc uccugcacac cuccacacuu gccgugcugg gcgcucucug cgucuacggg       60

gccggacauc uggagcagcc ccaaaucucu agcacgaaga cccuuuccaa aacagcgaga      120

cuggaaugug uugugucugg cauuaagauc agcgcuaccu ccguguauug guaccgggag      180

cgcccugggg aagucauuca guuccucgug ucuaucagcu augacggaac aguuagaaaa      240

gaguccggca uuccgagcgg gaaguuugaa guggaucgga uccccgagac cucuacaucc      300

acccugacga uccacaacgu cgagaaacag gacauugcca ccuacuauug cgcccugugg      360

gaagug                                                                 366


<210>  3688
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRPC1__Homo_sapiens__P48995

<400>  3688

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser 
1               5                   10                  15      


Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
            20                  25                  30          


Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
        35                  40                  45              


Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
    50                  55                  60                  


Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
65                  70                  75                  80  


Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn 
                85                  90                  95      


Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Ser Ala Asp 
            100                 105                 110         


Ala Leu Leu Val Ala Ile Asp Ser Glu Val Val Gly Ala Val Asp Ile 
        115                 120                 125             


Leu Leu Asn His Arg Pro Lys Arg Ser Ser Arg Pro Thr Ile Val Lys 
    130                 135                 140                 


Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val 
145                 150                 155                 160 


Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr 
                165                 170                 175     


Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly 
            180                 185                 190         


Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg 
        195                 200                 205             


His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala 
    210                 215                 220                 


Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu 
225                 230                 235                 240 


Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn 
                245                 250                 255     


Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu 
            260                 265                 270         


Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His 
        275                 280                 285             


Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg 
    290                 295                 300                 


Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu 
305                 310                 315                 320 


Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe 
                325                 330                 335     


Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met 
            340                 345                 350         


Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr 
        355                 360                 365             


Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe 
    370                 375                 380                 


Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu 
385                 390                 395                 400 


Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met 
                405                 410                 415     


Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile 
            420                 425                 430         


Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu 
        435                 440                 445             


Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser 
    450                 455                 460                 


Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe 
465                 470                 475                 480 


His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu 
                485                 490                 495     


Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg 
            500                 505                 510         


Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile 
        515                 520                 525             


Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe 
    530                 535                 540                 


Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp 
545                 550                 555                 560 


Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys 
                565                 570                 575     


Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe 
            580                 585                 590         


Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val 
        595                 600                 605             


Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val 
    610                 615                 620                 


Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu 
625                 630                 635                 640 


Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu 
                645                 650                 655     


Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe 
            660                 665                 670         


Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro 
        675                 680                 685             


Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser 
    690                 695                 700                 


His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp 
705                 710                 715                 720 


Arg Asn Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys 
                725                 730                 735     


Cys Leu Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser 
            740                 745                 750         


Thr Asp Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu 
        755                 760                 765             


Ser Lys Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser 
    770                 775                 780                 


Lys Tyr Ala Met Phe Tyr Pro Arg Asn 
785                 790             


<210>  3689
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRPC1__Homo_sapiens__AAA93251

<400>  3689
augauggcgg cccuguaccc gagcacggac cucucgggcg ccuccuccuc cucccugccu       60

uccucuccau ccucuuccuc gccgaacgag gugauggcgc ugaaggaugu gcgggaggug      120

aaggaggaga auacgcugaa ugagaagcuu uucuugcugg cgugcgacaa gggugacuau      180

uauaugguua aaaagauuuu ggaggaaaac aguucaggug acuugaacau aaauugcgua      240

gaugugcuug ggagaaaugc uguuaccaua acuauugaaa acgaaaacuu ggauauacug      300

cagcuucuuu uggacuacgg uugucagucu gcagaugcac uuuugguggc aaucgacucu      360

gaaguagugg gagcuguuga uauacuacuu aaucaucgac caaaacgauc aucaagacca      420

acuauaguaa aacuaaugga acgaauucag aauccugagu auucaacaac uauggauguu      480

gcaccuguca uuuuagcugc ucaucguaac aacuaugaaa uucuuacaau gcucuuaaaa      540

caggauguau cucuacccaa gccccaugca guuggcugug aaugcacauu guguucugca      600

aaaaacaaaa aggauagccu ccggcauucc agguuucguc uugauauaua ucgauguuug      660

gccaguccag cucuaauaau guuaacagag gaggauccaa uucugagagc auuugaacuu      720

agugcugauu uaaaagaacu aagucuugug gagguggaau ucaggaauga uuaugaggaa      780

cuagcccggc aauguaaaau guuugcuaag gauuuacuug cacaagcccg gaauucucgu      840

gaauuggaag uuauucuaaa ccauacgucu agugacgagc cucuugacaa acggggauua      900

uuagaagaaa gaaugaauuu aagucgucua aaacuugcua ucaaauauaa ccagaaagag      960

uuugucuccc agucuaacug ccagcaguuc cugaacacug uuugguuugg acagaugucg     1020

gguuaccgac gcaagcccac cuguaagaag auaaugacug uuuugacagu aggcaucuuu     1080

uggccaguuu ugucacuuug uuauuugaua gcucccaaau cucaguuugg cagaaucauu     1140

cacacaccuu uuaugaaauu uaucauucau ggagcaucau auuucacauu ucugcuguug     1200

cuuaaucuau acucucuugu cuacaaugag gauaagaaaa acacaauggg gccagcccuu     1260

gaaagaauag acuaucuucu uauucugugg auuauuggga ugauuugguc agacauuaaa     1320

agacucuggu augaaggguu ggaagacuuu uuagaagaau cucguaauca acucaguuuu     1380

gucaugaauu cucuuuauuu ggcaaccuuu gcccucaaag ugguugcuca caacaaguuu     1440

caugauuuug cugaucggaa ggauugggau gcauuccauc cuacacuggu ggcagaaggg     1500

cuuuuugcau uugcaaaugu ucuaaguuau cuucgucucu uuuuuaugua uacaaccagc     1560

ucuaucuugg guccauuaca gauuucaaug ggacagaugu uacaagauuu uggaaaauuu     1620

cuugggaugu uucuucuugu uuuguuuucu uucacaauug gacugacaca acuguaugau     1680

aaaggauaua cuucaaagga gcagaaggac uguguaggca ucuucuguga acagcaaagc     1740

aaugauaccu uccauucguu cauuggcacc ugcuuugcuu uguucuggua uauuuucucc     1800

uuagcgcaug uggcaaucuu ugucacaaga uuuagcuaug gagaagaacu gcaguccuuu     1860

gugggagcug ucauuguugg uacauacaau gucgugguug ugauugugcu uaccaaacug     1920

cugguggcaa ugcuucauaa aagcuuucag uugauagcaa aucaugaaga caaagaaugg     1980

aaguuugcuc gagcaaaauu auggcuuagc uacuuugaug acaaauguac guuaccucca     2040

ccuuucaaca ucauucccuc accaaagacu aucugcuaua ugauuaguag ccucaguaag     2100

uggauuugcu cucauacauc aaaaggcaag gucaaacggc aaaacaguuu aaaggaaugg     2160

aggaauuuga aacagaagag agaugaaaac uaucaaaaag ugaugugcug ccuagugcau     2220

cguuacuuga cuuccaugag acagaagaug caaaguacag aucaggcaac uguggaaaau     2280

cuaaacgaac ugcgccaaga ucugucaaaa uuccgaaaug aaauaaggga uuuacuuggc     2340

uuucggacuu cuaaauaugc uauguuuuau ccaagaaauu aa                        2382


<210>  3690
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRPC1__Homo_sapiens__AAA93251

<400>  3690
augauggccg cccuguaccc cagcaccgac cucuccggcg cgagcuccag cucccugccg       60

agcuccccca gcuccagcuc ccccaacgag gugauggccc ugaaggacgu ccgcgaggug      120

aaggaggaga acacccucaa cgagaagcug uuccugcucg ccugcgacaa gggggacuac      180

uacaugguga agaagauccu ggaggagaac agcuccggcg accugaacau caacugcguc      240

gacgugcucg ggcggaacgc cgugacgauc accaucgaga acgagaaccu ggacauccug      300

cagcuccugc uggacuacgg cugccagagc gccgacgcgc uccuggucgc caucgacucc      360

gagguggugg gggccgucga cauccugcuc aaccaccgcc ccaagcggag cucccgcccg      420

accaucguga agcugaugga gcggauccag aaccccgagu acagcaccac gauggacgug      480

gcccccguca uccuggcggc ccaccgcaac aacuacgaga uccucaccau gcugcugaag      540

caggacgugu cccuccccaa gccgcacgcc gugggcugcg agugcacccu gugcagcgcc      600

aagaacaaga aggacagccu gcggcacucc cgcuuccggc ucgacaucua ccgcugccug      660

gccagccccg cgcugaucau gcucaccgag gaggacccca uccugcgggc cuucgagcug      720

uccgccgacc ucaaggagcu gagccugguc gagguggagu uccgcaacga cuacgaggag      780

cucgcccggc agugcaagau guucgccaag gaccugcugg cgcaggcccg caacucccgg      840

gagcucgagg ugauccugaa ccacacgagc uccgacgagc cccuggacaa gcgcggccuc      900

cuggaggagc ggaugaaccu gagccgccuc aagcuggcca ucaaguacaa ccagaaggag      960

uucgucuccc agagcaacug ccagcaguuc cugaacaccg ugugguucgg gcagaugucc     1020

ggcuaccggc gcaagccgac cugcaagaag aucaugaccg ugcucacggu cgggaucuuc     1080

uggcccgugc ugagccugug cuaccugauc gcccccaagu cccaguucgg ccggaucauc     1140

cacacccccu ucaugaaguu caucauccac ggggccagcu acuucaccuu ccuccugcug     1200

cucaaccugu acucccuggu guacaacgag gacaagaaga acaccauggg cccggcgcuc     1260

gagcgcaucg acuaccugcu gauccucugg aucaucggca ugaucuggag cgacaucaag     1320

cgccuguggu acgaggggcu ggaggacuuc cucgaggagu cccggaacca gcugagcuuc     1380

gucaugaacu cccuguaccu cgccacguuc gcccugaagg uggucgccca caacaaguuc     1440

cacgacuucg ccgaccgcaa ggacugggac gcguuccacc ccacccuggu ggccgagggc     1500

cucuucgccu ucgccaacgu gcugagcuac cugcgccucu ucuucaugua caccaccagc     1560

uccauccugg ggccccugca gaucagcaug ggccagaugc uccaggacuu cggcaaguuc     1620

cuggggaugu uccugcucgu ccuguucucc uucacgaucg gccugaccca gcucuacgac     1680

aagggguaca ccagcaagga gcagaaggac ugcgugggca ucuucugcga gcagcagucc     1740

aacgacaccu uccacagcuu caucgggacg ugcuucgcgc uguucuggua caucuucucc     1800

cuggcccacg uggccaucuu cgucacccgg uucagcuacg gcgaggagcu ccaguccuuc     1860

gugggcgccg ugaucgucgg gaccuacaac gugguggucg ugaucgugcu gaccaagcug     1920

cucgucgcca ugcugcacaa gagcuuccag cugaucgcga accacgagga caaggagugg     1980

aaguucgccc gggccaagcu cuggcugucc uacuucgacg acaagugcac gcugcccccg     2040

cccuucaaca ucauccccag ccccaagacc aucugcuaca ugaucuccag ccucuccaag     2100

uggaucugca gccacaccuc caagggcaag gugaagcgcc agaacagccu gaaggagugg     2160

cggaaccuga agcagaagcg cgacgagaac uaccagaagg ugaugugcug ccucguccac     2220

cgguaccuga ccagcaugcg ccagaagaug caguccacgg accaggccac cguggagaac     2280

cugaacgagc uccggcagga ccugagcaag uuccgcaacg agauccggga ccugcucggg     2340

uuccgcaccu ccaaguacgc cauguucuac ccgcggaacu ga                        2382


<210>  3691
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRPC1__Homo_sapiens__AAA93251

<400>  3691
augauggccg cccucuaccc cuccaccgac cucuccggcg ccuccuccuc cucccucccc       60

uccucccccu ccuccuccuc ccccaacgag gucauggccc ucaaggacgu ccgcgagguc      120

aaggaggaga acacccucaa cgagaagcuc uuccuccucg ccugcgacaa gggcgacuac      180

uacaugguca agaagauccu cgaggagaac uccuccggcg accucaacau caacugcguc      240

gacguccucg gccgcaacgc cgucaccauc accaucgaga acgagaaccu cgacauccuc      300

cagcuccucc ucgacuacgg cugccagucc gccgacgccc uccucgucgc caucgacucc      360

gaggucgucg gcgccgucga cauccuccuc aaccaccgcc ccaagcgcuc cucccgcccc      420

accaucguca agcucaugga gcgcauccag aaccccgagu acuccaccac cauggacguc      480

gcccccguca uccucgccgc ccaccgcaac aacuacgaga uccucaccau gcuccucaag      540

caggacgucu cccuccccaa gccccacgcc gucggcugcg agugcacccu cugcuccgcc      600

aagaacaaga aggacucccu ccgccacucc cgcuuccgcc ucgacaucua ccgcugccuc      660

gccucccccg cccucaucau gcucaccgag gaggacccca uccuccgcgc cuucgagcuc      720

uccgccgacc ucaaggagcu cucccucguc gaggucgagu uccgcaacga cuacgaggag      780

cucgcccgcc agugcaagau guucgccaag gaccuccucg cccaggcccg caacucccgc      840

gagcucgagg ucauccucaa ccacaccucc uccgacgagc cccucgacaa gcgcggccuc      900

cucgaggagc gcaugaaccu cucccgccuc aagcucgcca ucaaguacaa ccagaaggag      960

uucgucuccc aguccaacug ccagcaguuc cucaacaccg ucugguucgg ccagaugucc     1020

ggcuaccgcc gcaagcccac cugcaagaag aucaugaccg uccucaccgu cggcaucuuc     1080

uggcccgucc ucucccucug cuaccucauc gcccccaagu cccaguucgg ccgcaucauc     1140

cacacccccu ucaugaaguu caucauccac ggcgccuccu acuucaccuu ccuccuccuc     1200

cucaaccucu acucccucgu cuacaacgag gacaagaaga acaccauggg ccccgcccuc     1260

gagcgcaucg acuaccuccu cauccucugg aucaucggca ugaucugguc cgacaucaag     1320

cgccucuggu acgagggccu cgaggacuuc cucgaggagu cccgcaacca gcucuccuuc     1380

gucaugaacu cccucuaccu cgccaccuuc gcccucaagg ucgucgccca caacaaguuc     1440

cacgacuucg ccgaccgcaa ggacugggac gccuuccacc ccacccucgu cgccgagggc     1500

cucuucgccu ucgccaacgu ccucuccuac cuccgccucu ucuucaugua caccaccucc     1560

uccauccucg gcccccucca gaucuccaug ggccagaugc uccaggacuu cggcaaguuc     1620

cucggcaugu uccuccucgu ccucuucucc uucaccaucg gccucaccca gcucuacgac     1680

aagggcuaca ccuccaagga gcagaaggac ugcgucggca ucuucugcga gcagcagucc     1740

aacgacaccu uccacuccuu caucggcacc ugcuucgccc ucuucuggua caucuucucc     1800

cucgcccacg ucgccaucuu cgucacccgc uucuccuacg gcgaggagcu ccaguccuuc     1860

gucggcgccg ucaucgucgg caccuacaac gucgucgucg ucaucguccu caccaagcuc     1920

cucgucgcca ugcuccacaa guccuuccag cucaucgcca accacgagga caaggagugg     1980

aaguucgccc gcgccaagcu cuggcucucc uacuucgacg acaagugcac ccuccccccc     2040

cccuucaaca ucauccccuc ccccaagacc aucugcuaca ugaucuccuc ccucuccaag     2100

uggaucugcu cccacaccuc caagggcaag gucaagcgcc agaacucccu caaggagugg     2160

cgcaaccuca agcagaagcg cgacgagaac uaccagaagg ucaugugcug ccucguccac     2220

cgcuaccuca ccuccaugcg ccagaagaug caguccaccg accaggccac cgucgagaac     2280

cucaacgagc uccgccagga ccucuccaag uuccgcaacg agauccgcga ccuccucggc     2340

uuccgcaccu ccaaguacgc cauguucuac ccccgcaacu ga                        2382


<210>  3692
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRPC1__Homo_sapiens__AAA93251

<400>  3692
augauggccg cucuguaccc cagcaccgac cucuccggcg caucuucaag uagccuuccu       60

uccucuccau cgucaagcag uccgaacgag gugauggccc ugaaggaugu cagagaaguu      120

aaagaggaaa auacauugaa cgagaaguua uuccugcuag cgugcgacaa aggggauuau      180

uacaugguga agaaaauccu cgaagaaaau uccucuggag accugaacau uaauugugua      240

gaugugcuug guaggaacgc ugucacuaua acgaucgaga augaaaaccu ggacauuuug      300

cagcuccugc uggauuaugg cugccaaagc gccgacgcac ucuuaguggc caucgauucc      360

gagguugugg gggcugucga cauucugcuu aaucaccggc ccaagcgcuc aagucgaccu      420

accaucguga aguugaugga acguauacag aacccagagu acagcacaac uauggaugua      480

gcacccguua uccuggccgc ucauagaaau aacuaugaga uucuaaccau gcuccugaaa      540

caggacgugu cucuuccuaa gccacacgcc gucggaugug aaugcacacu guguuccgcg      600

aaaaauaaga aagauucauu gaggcauagc cgguuucgcc ucgacaucua cagaugccug      660

gcaagucccg ccuuaauuau gcugaccgag gaagacccua uccucagggc uuucgagcuu      720

ucugccgauc ugaaggaauu gucccuagug gagguggagu uucggaacga cuaugaggag      780

cuggcacgcc aguguaagau guucgcuaaa gaucuccugg cccaagcgcg aaauagcaga      840

gaacuugagg ucauacugaa ccacacuucg ucugacgaac cauuggauaa gaggggccuc      900

cuggaggagc ggaugaacuu aucccgucug aaacuagcca uuaaguacaa ucagaaagaa      960

uuuguuucac agaguaacug ccagcaauuc cucaauacag ugugguuugg ucagaugagc     1020

ggguaccgca gaaagccgac cuguaaaaag aucaugacgg uacugacugu gggaauuuuc     1080

uggcccgucc uuuccuugug cuaucugauc gcaccuaagu cucaguuugg caggaucauu     1140

cauaccccau ucaugaaauu uauaauccac ggcgcuagcu acuucacauu ucuccugcuu     1200

cugaacuugu auucacucgu guacaaugag gacaagaaaa acacuauggg gcccgcccug     1260

gaacggauug auuauuuacu gauccuaugg auaauuggaa ugaucuggag ugacaucaag     1320

cgacucuggu acgagggucu ggaagauuuc cuugaggagu cccgcaauca guugagcuuc     1380

guuaugaacu cucuguaucu cgcuaccuuu gcccugaaag uggucgcaca caauaaguuc     1440

caugacuuug ccgauagaaa ggacugggac gcuuuccacc cuacauuagu ggcggaaggc     1500

cuguuugcau ucgccaacgu acuuucauac uugaggcucu uuuucaugua caccacgagu     1560

agcauucugg ggccacuaca aaucuccaug ggacagaugc ugcaggauuu uggcaaauuc     1620

cucgguaugu uucugcuugu uuuguucucu uuuacuauug ggcugacaca auuauaugac     1680

aagggauaca ccucgaaaga gcagaaggau ugugugggca uauucugcga acagcagagc     1740

aaugacacuu uccauuccuu uaucggcaca ugcuucgcuc ucuuuuggua uauuuucuca     1800

cuggcccacg ucgcaaucuu ugugacccgg uucaguuacg gggaggagcu ucaaucuuuu     1860

gucggagccg ugaucguugg uacguauaac gugguagucg ugauuguucu gaccaaauug     1920

cucguggcua ugcugcacaa gagcuuccag cuaauagcca aucaugaaga uaaggagugg     1980

aaauuugcac gcgcgaagcu guggcucucc uacuucgacg auaaauguac acugcccccg     2040

ccuuuuaaca ucauucccuc accaaagacu aucugcuaua ugauuagcuc ucuuuccaaa     2100

uggaucugua gucacaccag caagggcaag gucaaaagac aaaauucuuu gaaggaaugg     2160

aggaaccuga aacagaagcg ugacgagaac uaccagaaag ugaugugcug uuuaguacau     2220

cgguaccuca cauccaugcg acagaagaug cagucaacug aucaggcuac cguggaaaau     2280

cugaacgagc uuagacaaga ccugaguaaa uucaggaaug agauacgcga ucuacucggg     2340

uuucggacaa gcaaguaugc cauguucuac ccuagaaacu ga                        2382


<210>  3693
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRPC1__Homo_sapiens__AAA93251

<400>  3693
augauggccg cccuguaccc cagcaccgac cugagcggcg ccagcagcag cagccugccc       60

agcagcccca gcagcagcag ccccaacgag gugauggccc ugaaggacgu gagagaggug      120

aaggaggaga acacccugaa cgagaagcug uuccugcugg ccugcgacaa gggcgacuac      180

uacaugguga agaagauccu ggaggagaac agcagcggcg accugaacau caacugcgug      240

gacgugcugg gcagaaacgc cgugaccauc accaucgaga acgagaaccu ggacauccug      300

cagcugcugc uggacuacgg cugccagagc gccgacgccc ugcugguggc caucgacagc      360

gagguggugg gcgccgugga cauccugcug aaccacagac ccaagagaag cagcagaccc      420

accaucguga agcugaugga gagaauccag aaccccgagu acagcaccac cauggacgug      480

gcccccguga uccuggccgc ccacagaaac aacuacgaga uccugaccau gcugcugaag      540

caggacguga gccugcccaa gccccacgcc gugggcugcg agugcacccu gugcagcgcc      600

aagaacaaga aggacagccu gagacacagc agauucagac uggacaucua cagaugccug      660

gccagccccg cccugaucau gcugaccgag gaggacccca uccugagagc cuucgagcug      720

agcgccgacc ugaaggagcu gagccuggug gagguggagu ucagaaacga cuacgaggag      780

cuggccagac agugcaagau guucgccaag gaccugcugg cccaggccag aaacagcaga      840

gagcuggagg ugauccugaa ccacaccagc agcgacgagc cccuggacaa gagaggccug      900

cuggaggaga gaaugaaccu gagcagacug aagcuggcca ucaaguacaa ccagaaggag      960

uucgugagcc agagcaacug ccagcaguuc cugaacaccg ugugguucgg ccagaugagc     1020

ggcuacagaa gaaagcccac cugcaagaag aucaugaccg ugcugaccgu gggcaucuuc     1080

uggcccgugc ugagccugug cuaccugauc gcccccaaga gccaguucgg cagaaucauc     1140

cacacccccu ucaugaaguu caucauccac ggcgccagcu acuucaccuu ccugcugcug     1200

cugaaccugu acagccuggu guacaacgag gacaagaaga acaccauggg ccccgcccug     1260

gagagaaucg acuaccugcu gauccugugg aucaucggca ugaucuggag cgacaucaag     1320

agacuguggu acgagggccu ggaggacuuc cuggaggaga gcagaaacca gcugagcuuc     1380

gugaugaaca gccuguaccu ggccaccuuc gcccugaagg ugguggccca caacaaguuc     1440

cacgacuucg ccgacagaaa ggacugggac gccuuccacc ccacccuggu ggccgagggc     1500

cuguucgccu ucgccaacgu gcugagcuac cugagacugu ucuucaugua caccaccagc     1560

agcauccugg gcccccugca gaucagcaug ggccagaugc ugcaggacuu cggcaaguuc     1620

cugggcaugu uccugcuggu gcuguucagc uucaccaucg gccugaccca gcuguacgac     1680

aagggcuaca ccagcaagga gcagaaggac ugcgugggca ucuucugcga gcagcagagc     1740

aacgacaccu uccacagcuu caucggcacc ugcuucgccc uguucuggua caucuucagc     1800

cuggcccacg uggccaucuu cgugaccaga uucagcuacg gcgaggagcu gcagagcuuc     1860

gugggcgccg ugaucguggg caccuacaac gugguggugg ugaucgugcu gaccaagcug     1920

cugguggcca ugcugcacaa gagcuuccag cugaucgcca accacgagga caaggagugg     1980

aaguucgcca gagccaagcu guggcugagc uacuucgacg acaagugcac ccugcccccc     2040

cccuucaaca ucauccccag ccccaagacc aucugcuaca ugaucagcag ccugagcaag     2100

uggaucugca gccacaccag caagggcaag gugaagagac agaacagccu gaaggagugg     2160

agaaaccuga agcagaagag agacgagaac uaccagaagg ugaugugcug ccuggugcac     2220

agauaccuga ccagcaugag acagaagaug cagagcaccg accaggccac cguggagaac     2280

cugaacgagc ugagacagga ccugagcaag uucagaaacg agaucagaga ccugcugggc     2340

uucagaacca gcaaguacgc cauguucuac cccagaaacu ga                        2382


<210>  3694
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRPC1__Homo_sapiens__AAA93251

<400>  3694
augauggccg cucuguaccc cagcaccgac cucuccggcg ccucuagcuc cucucugccu       60

agcuccccgu cuagcuccag ccccaacgag gugauggcgc uuaaggaugu cagagaaguu      120

aaagaggaaa auacacugaa cgagaagcuc uuucugcuug cuugcgacaa aggggauuau      180

uacaugguga agaaaauccu ggaagaaaau ucuuccggag accucaacau uaauugugug      240

gauguccugg gccggaacgc cgugacgauc accauugaga augaaaaccu ggacauccuc      300

cagcugcuuc uggauuaugg gugccaaagc gccgacgcuc uccugguugc cauugauucu      360

gagguggucg gagcugugga cauccuucug aaucaccgcc cuaagagauc cagccggccc      420

acaaucguua agcucaugga acgcauucag aacccugagu acucuaccac aauggaugug      480

gcccccguca uccuggcggc ccauagaaau aacuaugaga uucugaccau gcuccugaaa      540

caggacgugu cccuuccuaa gccgcacgcu gugggcugug aaugcacacu guguagcgcc      600

aaaaauaaga aagauucccu ccggcauucu cgcuuuagac uggacaucua ccggugccuu      660

gcuagccccg cccugauuau gcucaccgag gaagacccua uccugcgcgc guucgagcug      720

uccgccgauc ucaaggaacu gagccuuguc gagguugagu uuagaaacga cuaugaggag      780

cuggcucggc aguguaagau guucgccaaa gaucuccugg cucaagcccg caauucuaga      840

gaacuugagg ugauucugaa ccacacgucc agcgacgaac cccucgauaa gcgggggcug      900

cuggaggagc gcaugaaccu cucuagacug aaacuugcca ucaaguacaa ucagaaagaa      960

uuugugagcc aguccaacug ccagcaauuc cugaauaccg ucugguuugg acagaugucu     1020

ggcuaccgga gaaagccuac auguaaaaag aucaugaccg ugcucacagu uggcauuuuc     1080

uggcccgugc ugagccugug cuaucuuauc gcuccgaagu cccaguuugg gcgcauuauc     1140

cauaccccuu ucaugaaauu uauuauccac ggagcgagcu acuucacguu ucuccugcug     1200

cucaaccugu auucucuugu cuacaaugag gacaagaaaa acacaauggg ccccgcccug     1260

gaacggaucg auuaucuccu gauucugugg aucauuggga ugaucugguc cgacauuaag     1320

agacuuuggu acgagggacu cgaagauuuc cuggaggaga gccgcaauca gcugucuuuc     1380

gugaugaacu cccucuaucu ggcuaccuuu gcccuuaaag uuguggccca caauaaguuc     1440

caugacuuug cugaucggaa ggacugggac gccuuccacc cuacacuggu cgcggaaggc     1500

cucuuugcuu ucgccaacgu gcugagcuac cugagacuuu ucuucaugua caccaccucc     1560

ucuauccucg ggccccugca aaucagcaug ggacagaugc ugcaggauuu uggcaaauuc     1620

cucggcaugu uucugcuugu ccuguucucc uuuacaauug ggcucacgca acuguaugac     1680

aagggauaca ccucuaaaga gcagaaggau ugugugggca ucuucugcga acagcagagc     1740

aaugacacau uccauuccuu uauugggacc ugcuucgccc uguuuuggua uaucuucagc     1800

cuugcucacg uugccauuuu ugugacacgc uucucuuacg gagaggagcu ccaauccuuu     1860

gucggcgcug ugaucguugg gaccuauaac guggucgugg ugauuguucu gacgaaacug     1920

cucgucgcca ugcugcacaa gagcuuccag cuuaucgcga aucaugaaga uaaggagugg     1980

aaauuugccc gggcuaagcu guggcucucu uacuucgacg auaaauguac acugcccccu     2040

ccguuuaaca ucauucccuc cccuaagacc aucugcuaua ugauuagcuc ucugagcaaa     2100

uggaucuguu cccacaccag caagggaaag gugaaaagac aaaauucucu uaaggaaugg     2160

cgcaaccuga aacagaagcg ggacgagaac uaccagaaag ugaugugcug ucucguccau     2220

agauaccuga cauccaugcg ccagaagaug cagagcaccg aucaggccac aguggaaaau     2280

cucaacgagc ugcggcaaga ccuuuccaaa uucagaaaug agauucggga ucugcucggc     2340

uuucgcacgu cuaaguaugc uauguucuac cccagaaacu ga                        2382


<210>  3695
<211>  1104
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRP-p8__Homo_sapiens__Q7Z2W7

<400>  3695

Met Ser Phe Arg Ala Ala Arg Leu Ser Met Arg Asn Arg Arg Asn Asp 
1               5                   10                  15      


Thr Leu Asp Ser Thr Arg Thr Leu Tyr Ser Ser Ala Ser Arg Ser Thr 
            20                  25                  30          


Asp Leu Ser Tyr Ser Glu Ser Asp Leu Val Asn Phe Ile Gln Ala Asn 
        35                  40                  45              


Phe Lys Lys Arg Glu Cys Val Phe Phe Thr Lys Asp Ser Lys Ala Thr 
    50                  55                  60                  


Glu Asn Val Cys Lys Cys Gly Tyr Ala Gln Ser Gln His Met Glu Gly 
65                  70                  75                  80  


Thr Gln Ile Asn Gln Ser Glu Lys Trp Asn Tyr Lys Lys His Thr Lys 
                85                  90                  95      


Glu Phe Pro Thr Asp Ala Phe Gly Asp Ile Gln Phe Glu Thr Leu Gly 
            100                 105                 110         


Lys Lys Gly Lys Tyr Ile Arg Leu Ser Cys Asp Thr Asp Ala Glu Ile 
        115                 120                 125             


Leu Tyr Glu Leu Leu Thr Gln His Trp His Leu Lys Thr Pro Asn Leu 
    130                 135                 140                 


Val Ile Ser Val Thr Gly Gly Ala Lys Asn Phe Ala Leu Lys Pro Arg 
145                 150                 155                 160 


Met Arg Lys Ile Phe Ser Arg Leu Ile Tyr Ile Ala Gln Ser Lys Gly 
                165                 170                 175     


Ala Trp Ile Leu Thr Gly Gly Thr His Tyr Gly Leu Met Lys Tyr Ile 
            180                 185                 190         


Gly Glu Val Val Arg Asp Asn Thr Ile Ser Arg Ser Ser Glu Glu Asn 
        195                 200                 205             


Ile Val Ala Ile Gly Ile Ala Ala Trp Gly Met Val Ser Asn Arg Asp 
    210                 215                 220                 


Thr Leu Ile Arg Asn Cys Asp Ala Glu Gly Tyr Phe Leu Ala Gln Tyr 
225                 230                 235                 240 


Leu Met Asp Asp Phe Thr Arg Asp Pro Leu Tyr Ile Leu Asp Asn Asn 
                245                 250                 255     


His Thr His Leu Leu Leu Val Asp Asn Gly Cys His Gly His Pro Thr 
            260                 265                 270         


Val Glu Ala Lys Leu Arg Asn Gln Leu Glu Lys Tyr Ile Ser Glu Arg 
        275                 280                 285             


Thr Ile Gln Asp Ser Asn Tyr Gly Gly Lys Ile Pro Ile Val Cys Phe 
    290                 295                 300                 


Ala Gln Gly Gly Gly Lys Glu Thr Leu Lys Ala Ile Asn Thr Ser Ile 
305                 310                 315                 320 


Lys Asn Lys Ile Pro Cys Val Val Val Glu Gly Ser Gly Gln Ile Ala 
                325                 330                 335     


Asp Val Ile Ala Ser Leu Val Glu Val Glu Asp Ala Leu Thr Ser Ser 
            340                 345                 350         


Ala Val Lys Glu Lys Leu Val Arg Phe Leu Pro Arg Thr Val Ser Arg 
        355                 360                 365             


Leu Pro Glu Glu Glu Thr Glu Ser Trp Ile Lys Trp Leu Lys Glu Ile 
    370                 375                 380                 


Leu Glu Cys Ser His Leu Leu Thr Val Ile Lys Met Glu Glu Ala Gly 
385                 390                 395                 400 


Asp Glu Ile Val Ser Asn Ala Ile Ser Tyr Ala Leu Tyr Lys Ala Phe 
                405                 410                 415     


Ser Thr Ser Glu Gln Asp Lys Asp Asn Trp Asn Gly Gln Leu Lys Leu 
            420                 425                 430         


Leu Leu Glu Trp Asn Gln Leu Asp Leu Ala Asn Asp Glu Ile Phe Thr 
        435                 440                 445             


Asn Asp Arg Arg Trp Glu Ser Ala Asp Leu Gln Glu Val Met Phe Thr 
    450                 455                 460                 


Ala Leu Ile Lys Asp Arg Pro Lys Phe Val Arg Leu Phe Leu Glu Asn 
465                 470                 475                 480 


Gly Leu Asn Leu Arg Lys Phe Leu Thr His Asp Val Leu Thr Glu Leu 
                485                 490                 495     


Phe Ser Asn His Phe Ser Thr Leu Val Tyr Arg Asn Leu Gln Ile Ala 
            500                 505                 510         


Lys Asn Ser Tyr Asn Asp Ala Leu Leu Thr Phe Val Trp Lys Leu Val 
        515                 520                 525             


Ala Asn Phe Arg Arg Gly Phe Arg Lys Glu Asp Arg Asn Gly Arg Asp 
    530                 535                 540                 


Glu Met Asp Ile Glu Leu His Asp Val Ser Pro Ile Thr Arg His Pro 
545                 550                 555                 560 


Leu Gln Ala Leu Phe Ile Trp Ala Ile Leu Gln Asn Lys Lys Glu Leu 
                565                 570                 575     


Ser Lys Val Ile Trp Glu Gln Thr Arg Gly Cys Thr Leu Ala Ala Leu 
            580                 585                 590         


Gly Ala Ser Lys Leu Leu Lys Thr Leu Ala Lys Val Lys Asn Asp Ile 
        595                 600                 605             


Asn Ala Ala Gly Glu Ser Glu Glu Leu Ala Asn Glu Tyr Glu Thr Arg 
    610                 615                 620                 


Ala Val Glu Leu Phe Thr Glu Cys Tyr Ser Ser Asp Glu Asp Leu Ala 
625                 630                 635                 640 


Glu Gln Leu Leu Val Tyr Ser Cys Glu Ala Trp Gly Gly Ser Asn Cys 
                645                 650                 655     


Leu Glu Leu Ala Val Glu Ala Thr Asp Gln His Phe Ile Ala Gln Pro 
            660                 665                 670         


Gly Val Gln Asn Phe Leu Ser Lys Gln Trp Tyr Gly Glu Ile Ser Arg 
        675                 680                 685             


Asp Thr Lys Asn Trp Lys Ile Ile Leu Cys Leu Phe Ile Ile Pro Leu 
    690                 695                 700                 


Val Gly Cys Gly Phe Val Ser Phe Arg Lys Lys Pro Val Asp Lys His 
705                 710                 715                 720 


Lys Lys Leu Leu Trp Tyr Tyr Val Ala Phe Phe Thr Ser Pro Phe Val 
                725                 730                 735     


Val Phe Ser Trp Asn Val Val Phe Tyr Ile Ala Phe Leu Leu Leu Phe 
            740                 745                 750         


Ala Tyr Val Leu Leu Met Asp Phe His Ser Val Pro His Pro Pro Glu 
        755                 760                 765             


Leu Val Leu Tyr Ser Leu Val Phe Val Leu Phe Cys Asp Glu Val Arg 
    770                 775                 780                 


Gln Trp Tyr Val Asn Gly Val Asn Tyr Phe Thr Asp Leu Trp Asn Val 
785                 790                 795                 800 


Met Asp Thr Leu Gly Leu Phe Tyr Phe Ile Ala Gly Ile Val Phe Arg 
                805                 810                 815     


Leu His Ser Ser Asn Lys Ser Ser Leu Tyr Ser Gly Arg Val Ile Phe 
            820                 825                 830         


Cys Leu Asp Tyr Ile Ile Phe Thr Leu Arg Leu Ile His Ile Phe Thr 
        835                 840                 845             


Val Ser Arg Asn Leu Gly Pro Lys Ile Ile Met Leu Gln Arg Met Leu 
    850                 855                 860                 


Ile Asp Val Phe Phe Phe Leu Phe Leu Phe Ala Val Trp Met Val Ala 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Gly Ile Leu Arg Gln Asn Glu Gln Arg Trp 
                885                 890                 895     


Arg Trp Ile Phe Arg Ser Val Ile Tyr Glu Pro Tyr Leu Ala Met Phe 
            900                 905                 910         


Gly Gln Val Pro Ser Asp Val Asp Gly Thr Thr Tyr Asp Phe Ala His 
        915                 920                 925             


Cys Thr Phe Thr Gly Asn Glu Ser Lys Pro Leu Cys Val Glu Leu Asp 
    930                 935                 940                 


Glu His Asn Leu Pro Arg Phe Pro Glu Trp Ile Thr Ile Pro Leu Val 
945                 950                 955                 960 


Cys Ile Tyr Met Leu Ser Thr Asn Ile Leu Leu Val Asn Leu Leu Val 
                965                 970                 975     


Ala Met Phe Gly Tyr Thr Val Gly Thr Val Gln Glu Asn Asn Asp Gln 
            980                 985                 990         


Val Trp Lys Phe Gln Arg Tyr Phe Leu Val Gln Glu Tyr Cys Ser Arg 
        995                 1000                1005            


Leu Asn Ile Pro Phe Pro Phe Ile Val Phe Ala Tyr Phe Tyr Met Val 
    1010                1015                1020                


Val Lys Lys Cys Phe Lys Cys Cys Cys Lys Glu Lys Asn Met Glu Ser 
1025                1030                1035                1040


Ser Val Cys Cys Phe Lys Asn Glu Asp Asn Glu Thr Leu Ala Trp Glu 
                1045                1050                1055    


Gly Val Met Lys Glu Asn Tyr Leu Val Lys Ile Asn Thr Lys Ala Asn 
            1060                1065                1070        


Asp Thr Ser Glu Glu Met Arg His Arg Phe Arg Gln Leu Asp Thr Lys 
        1075                1080                1085            


Leu Asn Asp Leu Lys Gly Leu Leu Lys Glu Ile Ala Asn Lys Ile Lys 
    1090                1095                1100                






<210>  3696
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRP-p8__Homo_sapiens__AAZ73614

<400>  3696
auguccuuuc gggcagccag gcucagcaug aggaacagaa ggaaugacac ucuggacagc       60

acccggaccc uguacuccag cgcgucucgg agcacagacu ugucuuacag ugaaagcgac      120

uuggugaauu uuauucaagc aaauuuuaag aaacgagaau gugucuucuu uaccaaagau      180

uccaaggcca cggagaaugu gugcaagugu ggcuaugccc agagccagca cauggaaggc      240

acccagauca accaaaguga gaaauggaac uacaagaaac acaccaagga auuuccuacc      300

gacgccuuug gggauauuca guuugagaca cuggggaaga aagggaagua uauacgucug      360

uccugcgaca cggacgcgga aauccuuuac gagcugcuga cccagcacug gcaccugaaa      420

acacccaacc uggucauuuc ugugaccggg ggcgccaaga acuucgcccu gaagccgcgc      480

augcgcaaga ucuucagccg gcucaucuac aucgcgcagu ccaaaggugc uuggauucuc      540

acgggaggca cccauuaugg ccugaugaag uacaucgggg agguggugag agauaacacc      600

aucagcagga guucagagga gaauauugug gccauuggca uagcagcuug gggcaugguc      660

uccaaccggg acacccucau caggaauugc gaugcugagg gcuauuuuuu agcccaguac      720

cuuauggaug acuucacaag agauccacug uauauccugg acaacaacca cacacauuug      780

cugcucgugg acaauggcug ucauggacau cccacugucg aagcaaagcu ccggaaucag      840

cuagagaagu auaucucuga gcgcacuauu caagauucca acuauggugg caagaucccc      900

auuguguguu uugcccaagg agguggaaaa gagacuuuga aagccaucaa uaccuccauc      960

aaaaauaaaa uuccuugugu ggugguggaa ggcucgggcc agaucgcuga ugugaucgcu     1020

agccuggugg agguggagga ugcccugaca ucuucugccg ucaaggagaa gcugguacgc     1080

uuuuuacccc gcacgguguc ccggcugccu gaggaggaga cugagaguug gaucaaaugg     1140

cucaaagaaa uucucgaaug uucucaccua uuaacaguua uuaaaaugga agaagcuggg     1200

gaugaaauug ugagcaaugc caucuccuac gcucuauaca aagccuucag caccagugag     1260

caagacaagg auaacuggaa ugggcagcug aagcuucugc uggaguggaa ccagcuggac     1320

uuagccaaug augagauuuu caccaaugac cgccgauggg agucugcuga ccuucaagaa     1380

gucauguuua cggcucucau aaaggacaga cccaaguuug uccgccucuu ucuggagaau     1440

ggcuugaacc uacggaaguu ucucacccau gauguccuca cugaacucuu cuccaaccac     1500

uucagcacgc uuguguaccg gaaucugcag aucgccaaga auuccuauaa ugaugcccuc     1560

cucacguuug ucuggaaacu gguugcgaac uuccgaagag gcuuccggaa ggaagacaga     1620

aauggccggg acgagaugga cauagaacuc cacgacgugu cuccuauuac ucggcacccc     1680

cugcaagcuc ucuucaucug ggccauucuu cagaauaaga aggaacucuc caaagucauu     1740

ugggagcaga ccaggggcug cacucuggca gcccugggag ccagcaagcu ucugaagacu     1800

cuggccaaag ugaagaacga caucaaugcu gcuggggagu ccgaggagcu ggcuaaugag     1860

uacgagaccc gggcuguuga gcuguucacu gaguguuaca gcagcgauga agacuuggca     1920

gaacagcugc uggucuauuc cugugaagcu ugggguggaa gcaacugucu ggagcuggcg     1980

guggaggcca cagaccagca uuucaucgcc cagccugggg uccagaauuu ucuuucuaag     2040

caaugguaug gagagauuuc ccgagacacc aagaacugga agauuauccu gugucuguuu     2100

auuauacccu uggugggcug uggcuuugua ucauuuagga agaaaccugu cgacaagcac     2160

aagaagcugc uuugguacua uguggcguuc uucaccuccc ccuucguggu cuucuccugg     2220

aauguggucu ucuacaucgc cuuccuccug cuguuugccu acgugcugcu cauggauuuc     2280

cauucggugc cacacccccc cgagcugguc cuguacucgc uggucuuugu ccucuucugu     2340

gaugaaguga gacaguggua cguaaauggg gugaauuauu uuacugaccu guggaaugug     2400

auggacacgc uggggcuuuu uuacuucaua gcaggaauug uauuucggcu ccacucuucu     2460

aauaaaagcu cuuuguauuc uggacgaguc auuuucuguc uggacuacau uauuuucacu     2520

cuaagauuga uccacauuuu uacuguaagc agaaacuuag gacccaagau uauaaugcug     2580

cagaggaugc ugaucgaugu guucuucuuc cuguuccucu uugcggugug gaugguggcc     2640

uuuggcgugg ccaggcaagg gauccuuagg cagaaugagc agcgcuggag guggauauuc     2700

cguucgguca ucuacgagcc cuaccuggcc auguucggcc aggugcccag ugacguggau     2760

gguaccacgu augacuuugc ccacugcacc uucacuggga augaguccaa gccacugugu     2820

guggagcugg augagcacaa ccugccccgg uuccccgagu ggaucaccau cccccuggug     2880

ugcaucuaca uguuauccac caacauccug cuggucaacc ugcuggucgc cauguuuggc     2940

uacacggugg gcaccgucca ggagaacaau gaccaggucu ggaaguucca gagguacuuc     3000

cuggugcagg aguacugcag ccgccucaau auccccuucc ccuucaucgu cuucgcuuac     3060

uucuacaugg uggugaagaa gugcuucaag uguugcugca aggagaaaaa cauggagucu     3120

ucugucugcu guuucaaaaa ugaagacaau gagacucugg caugggaggg ugucaugaag     3180

gaaaacuacc uugucaagau caacacaaaa gccaacgaca ccucagagga aaugaggcau     3240

cgauuuagac aacuggauac aaagcuuaau gaucucaagg gucuucugaa agagauugcu     3300

aauaaaauca aauaa                                                      3315


<210>  3697
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRP-p8__Homo_sapiens__AAZ73614

<400>  3697
augagcuucc gcgccgcccg gcuguccaug cgcaaccggc gcaacgacac ccucgacagc       60

acccggacgc uguacuccag cgcgucccgc agcaccgacc uguccuacag cgaguccgac      120

cucgugaacu ucauccaggc caacuucaag aagcgggagu gcgucuucuu caccaaggac      180

agcaaggcca ccgagaacgu gugcaagugc ggcuacgccc agucccagca cauggagggg      240

acgcagauca accagagcga gaaguggaac uacaagaagc acaccaagga guuccccacc      300

gacgccuucg gcgacaucca guucgagacc cuggggaaga agggcaagua cauccgccug      360

uccugcgaca cggacgcgga gauccucuac gagcugcuga cccagcacug gcaccucaag      420

accccgaacc uggugaucag cgucaccggg ggcgccaaga acuucgcccu gaagccccgg      480

augcgcaaga ucuucucccg gcucaucuac aucgcccaga gcaagggcgc guggauccug      540

accgggggca cgcacuacgg gcugaugaag uacaucggcg agguggugcg cgacaacacc      600

aucucccgga gcuccgagga gaacaucguc gccaucggga ucgccgccug gggcauggug      660

agcaaccgcg acacccucau ccggaacugc gacgccgagg gcuacuuccu ggcgcaguac      720

cugauggacg acuucacgcg cgacccccuc uacauccugg acaacaacca cacccaccuc      780

cuccuggugg acaacgggug ccacggccac cccaccgucg aggccaagcu gcggaaccag      840

cucgagaagu acaucagcga gcgcaccauc caggacucca acuacggggg caagaucccg      900

aucgugugcu ucgcccaggg cgggggcaag gagacgcuga aggccaucaa caccagcauc      960

aagaacaaga uccccugcgu ggucguggag ggguccggcc agaucgccga cgugaucgcg     1020

agccuggucg agguggagga cgcccucacc uccagcgccg ugaaggagaa gcugguccgg     1080

uuccugcccc gcaccguguc ccggcucccc gaggaggaga cggagagcug gaucaagugg     1140

cugaaggaga uccuggagug cucccaccuc cugaccguga ucaagaugga ggaggccggg     1200

gacgagaucg ucagcaacgc caucuccuac gcgcuguaca aggccuucag caccuccgag     1260

caggacaagg acaacuggaa cggccagcuc aagcugcugc ucgaguggaa ccagcuggac     1320

cuggccaacg acgagaucuu caccaacgac cgccgcuggg agagcgccga ccuccaggag     1380

gugauguuca cggcccugau caaggaccgg ccgaaguucg ugcgccuguu ccucgagaac     1440

ggccugaacc ugcggaaguu ccucacccac gacguccuga ccgagcuguu cuccaaccac     1500

uucagcaccc ugguguaccg caaccuccag aucgcgaaga acuccuacaa cgacgcccug     1560

cugacguucg ucuggaagcu cguggccaac uuccggcgcg gguuccggaa ggaggaccgc     1620

aacggccggg acgagaugga caucgagcug cacgacguga gccccaucac ccgccacccc     1680

cugcaggccc ucuucaucug ggcgauccug cagaacaaga aggagcuguc caaggucauc     1740

ugggagcaga cccgggggug cacccucgcc gcccugggcg ccagcaagcu gcucaagacg     1800

cuggccaagg ugaagaacga caucaacgcg gccggggaga gcgaggagcu ggccaacgag     1860

uacgagaccc gcgccgugga gcuguucacc gagugcuacu ccagcgacga ggaccuggcc     1920

gagcagcugc ucgucuacuc cugcgaggcg uggggcggca gcaacugccu ggagcuggcc     1980

guggaggcca ccgaccagca cuucaucgcc cagcccgggg ugcagaacuu ccucuccaag     2040

cagugguacg gcgagaucag ccgggacacc aagaacugga agaucauccu gugccuguuc     2100

aucaucccgc ucgucgggug cggcuucgug uccuuccgca agaagcccgu ggacaagcac     2160

aagaagcugc ugugguacua cgucgccuuc uucacgagcc ccuucguggu guucuccugg     2220

aacgucgugu ucuacaucgc guuccuccug cuguucgccu acgugcuccu gauggacuuc     2280

cacagcgucc cccacccgcc cgagcuggug cucuacuccc ugguguucgu ccuguucugc     2340

gacgaggugc ggcaguggua cgugaacggg gucaacuacu ucaccgaccu cuggaacgug     2400

auggacaccc ugggccuguu cuacuucauc gccggcaucg uguuccgccu ccacagcucc     2460

aacaagagcu cccuguacag cgggcggguc aucuucugcc uggacuacau caucuucacc     2520

cuccgccuga uccacaucuu cacggugucc cggaaccugg gccccaagau caucaugcuc     2580

cagcgcaugc ugaucgacgu guucuucuuc cuguuccucu ucgccgucug gaugguggcg     2640

uucggggugg cccgccaggg cauccugcgg cagaacgagc agcgcuggcg guggaucuuc     2700

cgcagcguca ucuacgagcc cuaccuggcc auguucggcc aggugccgag cgacguggac     2760

gggaccaccu acgacuucgc ccacugcacc uucacgggca acgaguccaa gccccucugc     2820

gucgagcugg acgagcacaa ccugccccgg uuccccgagu ggaucaccau cccgcucgug     2880

ugcaucuaca ugcugagcac caacauccug cucgugaacc ugcuggucgc cauguucggg     2940

uacaccgugg gcacggugca ggagaacaac gaccaggucu ggaaguucca gcgcuacuuc     3000

cucgugcagg aguacugcuc ccggcugaac auccccuucc ccuucaucgu guucgcguac     3060

uucuacaugg ucgugaagaa gugcuucaag ugcugcugca aggagaagaa cauggagagc     3120

uccgugugcu gcuucaagaa cgaggacaac gagacccugg ccugggaggg ggucaugaag     3180

gagaacuacc ucgugaagau caacaccaag gccaacgaca ccagcgagga gaugcgccac     3240

cgguuccgcc agcuggacac gaagcugaac gaccucaagg gccugcugaa ggagaucgcc     3300

aacaagauca aguga                                                      3315


<210>  3698
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRP-p8__Homo_sapiens__AAZ73614

<400>  3698
auguccuucc gcgccgcccg ccucuccaug cgcaaccgcc gcaacgacac ccucgacucc       60

acccgcaccc ucuacuccuc cgccucccgc uccaccgacc ucuccuacuc cgaguccgac      120

cucgucaacu ucauccaggc caacuucaag aagcgcgagu gcgucuucuu caccaaggac      180

uccaaggcca ccgagaacgu cugcaagugc ggcuacgccc agucccagca cauggagggc      240

acccagauca accaguccga gaaguggaac uacaagaagc acaccaagga guuccccacc      300

gacgccuucg gcgacaucca guucgagacc cucggcaaga agggcaagua cauccgccuc      360

uccugcgaca ccgacgccga gauccucuac gagcuccuca cccagcacug gcaccucaag      420

acccccaacc ucgucaucuc cgucaccggc ggcgccaaga acuucgcccu caagccccgc      480

augcgcaaga ucuucucccg ccucaucuac aucgcccagu ccaagggcgc cuggauccuc      540

accggcggca cccacuacgg ccucaugaag uacaucggcg aggucguccg cgacaacacc      600

aucucccgcu ccuccgagga gaacaucguc gccaucggca ucgccgccug gggcaugguc      660

uccaaccgcg acacccucau ccgcaacugc gacgccgagg gcuacuuccu cgcccaguac      720

cucauggacg acuucacccg cgacccccuc uacauccucg acaacaacca cacccaccuc      780

cuccucgucg acaacggcug ccacggccac cccaccgucg aggccaagcu ccgcaaccag      840

cucgagaagu acaucuccga gcgcaccauc caggacucca acuacggcgg caagaucccc      900

aucgucugcu ucgcccaggg cggcggcaag gagacccuca aggccaucaa caccuccauc      960

aagaacaaga uccccugcgu cgucgucgag ggcuccggcc agaucgccga cgucaucgcc     1020

ucccucgucg aggucgagga cgcccucacc uccuccgccg ucaaggagaa gcucguccgc     1080

uuccuccccc gcaccgucuc ccgccucccc gaggaggaga ccgaguccug gaucaagugg     1140

cucaaggaga uccucgagug cucccaccuc cucaccguca ucaagaugga ggaggccggc     1200

gacgagaucg ucuccaacgc caucuccuac gcccucuaca aggccuucuc caccuccgag     1260

caggacaagg acaacuggaa cggccagcuc aagcuccucc ucgaguggaa ccagcucgac     1320

cucgccaacg acgagaucuu caccaacgac cgccgcuggg aguccgccga ccuccaggag     1380

gucauguuca ccgcccucau caaggaccgc cccaaguucg uccgccucuu ccucgagaac     1440

ggccucaacc uccgcaaguu ccucacccac gacguccuca ccgagcucuu cuccaaccac     1500

uucuccaccc ucgucuaccg caaccuccag aucgccaaga acuccuacaa cgacgcccuc     1560

cucaccuucg ucuggaagcu cgucgccaac uuccgccgcg gcuuccgcaa ggaggaccgc     1620

aacggccgcg acgagaugga caucgagcuc cacgacgucu cccccaucac ccgccacccc     1680

cuccaggccc ucuucaucug ggccauccuc cagaacaaga aggagcucuc caaggucauc     1740

ugggagcaga cccgcggcug cacccucgcc gcccucggcg ccuccaagcu ccucaagacc     1800

cucgccaagg ucaagaacga caucaacgcc gccggcgagu ccgaggagcu cgccaacgag     1860

uacgagaccc gcgccgucga gcucuucacc gagugcuacu ccuccgacga ggaccucgcc     1920

gagcagcucc ucgucuacuc cugcgaggcc uggggcggcu ccaacugccu cgagcucgcc     1980

gucgaggcca ccgaccagca cuucaucgcc cagcccggcg uccagaacuu ccucuccaag     2040

cagugguacg gcgagaucuc ccgcgacacc aagaacugga agaucauccu cugccucuuc     2100

aucauccccc ucgucggcug cggcuucguc uccuuccgca agaagcccgu cgacaagcac     2160

aagaagcucc ucugguacua cgucgccuuc uucaccuccc ccuucgucgu cuucuccugg     2220

aacgucgucu ucuacaucgc cuuccuccuc cucuucgccu acguccuccu cauggacuuc     2280

cacuccgucc cccacccccc cgagcucguc cucuacuccc ucgucuucgu ccucuucugc     2340

gacgaggucc gccaguggua cgucaacggc gucaacuacu ucaccgaccu cuggaacguc     2400

auggacaccc ucggccucuu cuacuucauc gccggcaucg ucuuccgccu ccacuccucc     2460

aacaaguccu cccucuacuc cggccgcguc aucuucugcc ucgacuacau caucuucacc     2520

cuccgccuca uccacaucuu caccgucucc cgcaaccucg gccccaagau caucaugcuc     2580

cagcgcaugc ucaucgacgu cuucuucuuc cucuuccucu ucgccgucug gauggucgcc     2640

uucggcgucg cccgccaggg cauccuccgc cagaacgagc agcgcuggcg cuggaucuuc     2700

cgcuccguca ucuacgagcc cuaccucgcc auguucggcc agguccccuc cgacgucgac     2760

ggcaccaccu acgacuucgc ccacugcacc uucaccggca acgaguccaa gccccucugc     2820

gucgagcucg acgagcacaa ccucccccgc uuccccgagu ggaucaccau cccccucguc     2880

ugcaucuaca ugcucuccac caacauccuc cucgucaacc uccucgucgc cauguucggc     2940

uacaccgucg gcaccgucca ggagaacaac gaccaggucu ggaaguucca gcgcuacuuc     3000

cucguccagg aguacugcuc ccgccucaac auccccuucc ccuucaucgu cuucgccuac     3060

uucuacaugg ucgucaagaa gugcuucaag ugcugcugca aggagaagaa cauggagucc     3120

uccgucugcu gcuucaagaa cgaggacaac gagacccucg ccugggaggg cgucaugaag     3180

gagaacuacc ucgucaagau caacaccaag gccaacgaca ccuccgagga gaugcgccac     3240

cgcuuccgcc agcucgacac caagcucaac gaccucaagg gccuccucaa ggagaucgcc     3300

aacaagauca aguga                                                      3315


<210>  3699
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRP-p8__Homo_sapiens__AAZ73614

<400>  3699
augagcuuca gagccgcuag gcuguccaug cggaaccgcc gaaaugacac ccucgauucu       60

acacguacuc uuuacucaag ugcaagcaga uccacggacc ugucuuauuc ggagucagau      120

uuggugaacu uuauccaggc caauuucaag aaaagggaau gcgucuuuuu caccaaggac      180

agcaaagcga cagagaacgu uuguaagugc ggcuacgcuc aaagucagca cauggaaggg      240

acucagauua aucaguccga gaaauggaac uauaagaagc auaccaaaga auuucccaca      300

gaugccuucg gagacauaca auuugagacc uuagguaaga aaggcaagua cauccggcug      360

ucuugugaua cugacgcaga gauucuauau gaacuccuga cacagcacug gcaucuuaaa      420

accccuaauc uggugaucag cguaacuggg ggagccaaga acuucgcuuu gaagccacgc      480

augagaaaaa ucuuuuccag gcucauuuac auagcacagu caaagggcgc cuggauccug      540

acggguggga cccacuaugg acugaugaaa uacauuggcg aggugguccg ggauaauaca      600

aucagucgca gcucugaaga gaacauugug gcuaucggca uagccgcgug ggggaugguu      660

uccaaucgag acacucucau uagaaacugc gaugcagagg gauacuucuu agcccaguau      720

cugauggacg auuuuaccag ggacccgcuu uacaucuugg acaauaacca uacacaccuu      780

cuacucgugg auaaugguug ucacggccau cccaccgucg aagcuaagcu gcggaaccaa      840

cuugagaaau auauuucaga acguacgauc caggacagca acuacggggg aaagaucccu      900

auugugugcu ucgcccaggg cggugggaaa gagacucuga aggcaauaaa uacaaguauc      960

aagaacaaaa uuccaugugu aguuguggaa ggaucuggcc agaucgcuga ugucauagcc     1020

uccuuggugg agguggagga cgcgcucacc agcucggccg ucaaggaaaa acugguucgc     1080

uuuuuaccca gaacuguguc uaggcugccu gaggaagaga cagaauccug gauuaagugg     1140

cucaaagaga uccuugagug cucacaccug uugaccguaa ucaagaugga agaggcaggc     1200

gaugaaauug ugaguaaugc uaucagcuau gcccuauaca aggcuuucuc cacgucugag     1260

caagacaaag auaacuggaa ugggcagcug aagcuccugc uugaauggaa ccagcuggac     1320

uuggccaaug augagauuuu caccaacgac cggcgauggg agagcgcaga ucuccaagaa     1380

gucauguuua cagcccugau aaaagaccgc ccaaaguucg ugagauuauu ucuggagaau     1440

ggacuaaacc ucaggaaauu ccugacucau gacguucuua ccgaauuguu uucaaaucac     1500

uucaguacac ugguguaucg gaaccuccag aucgcuaaaa auuccuacaa cgaugcgcug     1560

cuuacuuuug ucuggaagcu gguggcaaau uuccgcagag guuuuaggaa ggaggaccgu     1620

aacggccggg augagaugga cauugaauug cacgauguaa gccccaucac ccgacauccu     1680

cuccaggccc uguucaucug ggcuauuuua cagaacaaga aagagcuguc uaagguuaua     1740

ugggaacaaa caagagggug uacccuagcc gcacucggag ccucaaaacu gcuuaagacu     1800

uuggcuaagg ugaaaaauga caucaacgcc gcaggcgaga gugaggaacu ggcgaaugag     1860

uacgaaacga gggcugucga gcucuuuaca gaaugcuaua gcuccgauga ggaccuggcc     1920

gaacaguuac ugguguacuc uugugaggca uggggugggu cgaacugccu ugaguuggcc     1980

gucgaagcua ccgaucagca cuucauugcc cagccaggcg ugcaaaauuu ucucagcaag     2040

cagugguaug gagagaucuc ccgcgacacu aaaaacugga agauuauccu gugccuauuc     2100

auaaucccgc ugguuggcug uggguucgug ucauuucgga aaaagcccgu agauaaacau     2160

aagaagcucc ugugguacua ugucgcauuc uuuaccaguc cuuucguggu guuuucuugg     2220

aauguugucu ucuacauugc uuuucuuuug cuguucgccu auguguuacu cauggacuuu     2280

cacagcguac cacauccccc ugaacuggug cuuuacuccc ugguuuucgu cuuguuuugc     2340

gaugagguga gacaguggua cgugaacgga gucaauuauu ucacagaccu cuggaacguu     2400

auggacaccc ugggucuauu uuacuucauc gcgggcauug uguucaggcu gcacucaagc     2460

aauaaaucuu cccucuauag ugggcgcgug aucuuuuguc uggauuacau aauuuucacu     2520

cuucgauuga uccacauuuu uacaguaagc cggaaccugg gaccaaagau cauaauguua     2580

cagcguaugc ucaucgacgu cuucuuuuuc cuguuucuuu ucgccgugug gaugguugcu     2640

uuuggcgugg caagacaagg uauucugagg cagaaugaac agcgcuggcg guggaucuuc     2700

agaucuguca uuuaugagcc cuaccuagcc auguuuggcc aggugccguc cgauguugac     2760

gggacgaccu augauuucgc ucauugcacu uucacaggaa acgagucaaa accucucugu     2820

guggaacugg acgagcacaa uuugcccagg uuuccagaau ggaucaccau accucuggua     2880

ugcauuuaca uguuaaguac aaacauccuc cuggucaacc uucugguggc cauguucggc     2940

uacacugugg ggaccgucca agagaauaac gaucagguuu ggaaguuuca gcgauauuuc     3000

uuggugcaag aguacuguag ccgccucaau auccccuuuc cauucauugu auuugcauau     3060

uucuacaugg uggucaaaaa gugcuuuaag uguugcugua aagaaaagaa cauggagucg     3120

uccgugugcu gcuucaaaaa ugaagacaac gagacgcugg cgugggaagg aguuaugaag     3180

gagaauuauc uagugaaaau caacaccaag gccaaugaua caucugagga aaugcggcau     3240

agauuuaggc agcuggacac uaagcugaac gaucucaaag gucuguugaa ggagauugcu     3300

aauaaaauaa aguga                                                      3315


<210>  3700
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRP-p8__Homo_sapiens__AAZ73614

<400>  3700
augagcuuca gagccgccag acugagcaug agaaacagaa gaaacgacac ccuggacagc       60

accagaaccc uguacagcag cgccagcaga agcaccgacc ugagcuacag cgagagcgac      120

cuggugaacu ucauccaggc caacuucaag aagagagagu gcguguucuu caccaaggac      180

agcaaggcca ccgagaacgu gugcaagugc ggcuacgccc agagccagca cauggagggc      240

acccagauca accagagcga gaaguggaac uacaagaagc acaccaagga guuccccacc      300

gacgccuucg gcgacaucca guucgagacc cugggcaaga agggcaagua caucagacug      360

agcugcgaca ccgacgccga gauccuguac gagcugcuga cccagcacug gcaccugaag      420

acccccaacc uggugaucag cgugaccggc ggcgccaaga acuucgcccu gaagcccaga      480

augagaaaga ucuucagcag acugaucuac aucgcccaga gcaagggcgc cuggauccug      540

accggcggca cccacuacgg ccugaugaag uacaucggcg agguggugag agacaacacc      600

aucagcagaa gcagcgagga gaacaucgug gccaucggca ucgccgccug gggcauggug      660

agcaacagag acacccugau cagaaacugc gacgccgagg gcuacuuccu ggcccaguac      720

cugauggacg acuucaccag agacccccug uacauccugg acaacaacca cacccaccug      780

cugcuggugg acaacggcug ccacggccac cccaccgugg aggccaagcu gagaaaccag      840

cuggagaagu acaucagcga gagaaccauc caggacagca acuacggcgg caagaucccc      900

aucgugugcu ucgcccaggg cggcggcaag gagacccuga aggccaucaa caccagcauc      960

aagaacaaga uccccugcgu ggugguggag ggcagcggcc agaucgccga cgugaucgcc     1020

agccuggugg agguggagga cgcccugacc agcagcgccg ugaaggagaa gcuggugaga     1080

uuccugccca gaaccgugag cagacugccc gaggaggaga ccgagagcug gaucaagugg     1140

cugaaggaga uccuggagug cagccaccug cugaccguga ucaagaugga ggaggccggc     1200

gacgagaucg ugagcaacgc caucagcuac gcccuguaca aggccuucag caccagcgag     1260

caggacaagg acaacuggaa cggccagcug aagcugcugc uggaguggaa ccagcuggac     1320

cuggccaacg acgagaucuu caccaacgac agaagauggg agagcgccga ccugcaggag     1380

gugauguuca ccgcccugau caaggacaga cccaaguucg ugagacuguu ccuggagaac     1440

ggccugaacc ugagaaaguu ccugacccac gacgugcuga ccgagcuguu cagcaaccac     1500

uucagcaccc ugguguacag aaaccugcag aucgccaaga acagcuacaa cgacgcccug     1560

cugaccuucg uguggaagcu gguggccaac uucagaagag gcuucagaaa ggaggacaga     1620

aacggcagag acgagaugga caucgagcug cacgacguga gccccaucac cagacacccc     1680

cugcaggccc uguucaucug ggccauccug cagaacaaga aggagcugag caaggugauc     1740

ugggagcaga ccagaggcug cacccuggcc gcccugggcg ccagcaagcu gcugaagacc     1800

cuggccaagg ugaagaacga caucaacgcc gccggcgaga gcgaggagcu ggccaacgag     1860

uacgagacca gagccgugga gcuguucacc gagugcuaca gcagcgacga ggaccuggcc     1920

gagcagcugc ugguguacag cugcgaggcc uggggcggca gcaacugccu ggagcuggcc     1980

guggaggcca ccgaccagca cuucaucgcc cagcccggcg ugcagaacuu ccugagcaag     2040

cagugguacg gcgagaucag cagagacacc aagaacugga agaucauccu gugccuguuc     2100

aucauccccc uggugggcug cggcuucgug agcuucagaa agaagcccgu ggacaagcac     2160

aagaagcugc ugugguacua cguggccuuc uucaccagcc ccuucguggu guucagcugg     2220

aacguggugu ucuacaucgc cuuccugcug cuguucgccu acgugcugcu gauggacuuc     2280

cacagcgugc cccacccccc cgagcuggug cuguacagcc ugguguucgu gcuguucugc     2340

gacgagguga gacaguggua cgugaacggc gugaacuacu ucaccgaccu guggaacgug     2400

auggacaccc ugggccuguu cuacuucauc gccggcaucg uguucagacu gcacagcagc     2460

aacaagagca gccuguacag cggcagagug aucuucugcc uggacuacau caucuucacc     2520

cugagacuga uccacaucuu caccgugagc agaaaccugg gccccaagau caucaugcug     2580

cagagaaugc ugaucgacgu guucuucuuc cuguuccugu ucgccgugug gaugguggcc     2640

uucggcgugg ccagacaggg cauccugaga cagaacgagc agagauggag auggaucuuc     2700

agaagcguga ucuacgagcc cuaccuggcc auguucggcc aggugcccag cgacguggac     2760

ggcaccaccu acgacuucgc ccacugcacc uucaccggca acgagagcaa gccccugugc     2820

guggagcugg acgagcacaa ccugcccaga uuccccgagu ggaucaccau cccccuggug     2880

ugcaucuaca ugcugagcac caacauccug cuggugaacc ugcugguggc cauguucggc     2940

uacaccgugg gcaccgugca ggagaacaac gaccaggugu ggaaguucca gagauacuuc     3000

cuggugcagg aguacugcag cagacugaac auccccuucc ccuucaucgu guucgccuac     3060

uucuacaugg uggugaagaa gugcuucaag ugcugcugca aggagaagaa cauggagagc     3120

agcgugugcu gcuucaagaa cgaggacaac gagacccugg ccugggaggg cgugaugaag     3180

gagaacuacc uggugaagau caacaccaag gccaacgaca ccagcgagga gaugagacac     3240

agauucagac agcuggacac caagcugaac gaccugaagg gccugcugaa ggagaucgcc     3300

aacaagauca aguga                                                      3315


<210>  3701
<211>  3315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRP-p8__Homo_sapiens__AAZ73614

<400>  3701
augagcuuca gagccgcucg gcuguccaug cgcaacagac ggaaugacac ccucgauucu       60

acacgcacgc uguacagcuc cgccucuaga agcaccgacc uuuccuauuc ugagagcgau      120

cuggugaacu uuauccaggc gaauuucaag aaacgggaau gcgucuuuuu cacaaaggac      180

uccaaagcua ccgagaacgu uuguaagugc ggcuacgccc aaagccagca cauggaaggg      240

acacagauua aucagucuga gaaauggaac uauaagaagc auaccaaaga auuucccaca      300

gaugccuucg gagacaucca auuugagacc cucggcaaga aagggaagua cauucgccug      360

uccugugaua cggacgcuga gauccuuuau gaacugcuca cccagcacug gcaucugaaa      420

acaccuaauc uggugauuag cgugaccgga ggcgccaaga acuucgcucu caagccgaga      480

augcggaaaa ucuuuucucg ccugaucuac auugcccagu ccaagggggc guggauccuu      540

acaggaggca cccacuaugg ccugaugaaa uacauugggg aggucgugag agauaauacg      600

aucagccggu cuuccgaaga gaacauuguu gccaucggaa uugcugccug gggcauggug      660

agcaaucgcg acacacucau cagaaacugc gaugcugagg gguacuuccu ggcccaguau      720

cuuauggacg auuuuacccg ggacccccug uacauccucg acaauaacca uacacaccuu      780

cugcucgucg auaauggaug ucacggccau ccuaccgugg aagcgaagcu gcgcaaccaa      840

cuugagaaau auauuuccga aagaaccauc caggacucua acuacggggg aaagauuccc      900

aucguuugcu ucgcccaggg cggcgggaaa gagacacuga aggcuauuaa uacgagcauc      960

aagaacaaaa ucccuugugu ggucguggaa ggauccggcc agauugccga ugugaucgcu     1020

agccucgucg agguugagga cgcccugacc ucuuccgccg ugaaggaaaa acuugugcgg     1080

uuucugccca gaacagucag ccgccucccu gaggaagaga ccgaaucuug gauuaagugg     1140

cugaaagaga uccuggagug cagccaccuc cugacaguga uuaagaugga agaggcuggg     1200

gaugaaaucg uuuccaaugc gaucucuuau gcccuuuaca aggcuuucag caccuccgag     1260

caagacaaag auaacuggaa uggacagcug aagcuccugc uugaauggaa ccagcuggac     1320

cucgccaaug augagauuuu cacgaacgac cggagauggg agagcgccga ucugcaagaa     1380

gugauguuua cagcucugau caaagaccgc ccgaaguucg uccggcucuu ucuggagaau     1440

ggccuuaacc ugagaaaauu ccucacccau gacgugcuga ccgaacuguu uucuaaucac     1500

uucuccacac uuguuuaucg caaccuccag auugccaaga auagcuacaa cgaugcgcug     1560

cugaccuuug uguggaagcu cgucgcuaau uuccggagag gguuucgcaa agaggaccgg     1620

aacggaagag augagaugga caucgaacug cacgaugugu cucccauuac acgccauccu     1680

cuucaggccc uguucaucug ggccauucuc cagaacaaga aagagcuguc caaggucauc     1740

ugggaacaaa cgcggggcug uacccuggcu gcccuuggcg cuagcaaacu ccugaagaca     1800

cuggccaagg ugaaaaauga caucaacgcg gccggggagu ccgaggaacu cgcuaaugag     1860

uacgaaacca gagccguuga gcuguuuaca gaaugcuauu cuagcgauga ggaccuugcu     1920

gaacagcugc ucguguacuc cugugaggcc uggggaggcu cuaacugccu ggagcuggcg     1980

gucgaagcca ccgaucagca cuucauugcu cagcccgggg ugcaaaauuu ucuuagcaag     2040

cagugguaug gagagaucuc ccgggacacg aaaaacugga agauuauccu cugccuguuc     2100

auuaucccuc ugguuggcug uggguucgug agcuuucgca aaaagcccgu cgauaaacau     2160

aagaagcucc ugugguacua uguggccuuc uuuaccucuc cguucguggu cuuuuccugg     2220

aauguugugu ucuacaucgc uuuucuucuu cucuucgccu augugcugcu gauggacuuu     2280

cacagcgucc cucauccccc ugaacuugug cucuacucuc ugguuuucgu gcuguuuugc     2340

gaugagguca gacaguggua cgugaacggc guuaauuauu ucacagaccu cuggaacgug     2400

auggacaccc ugggacuguu uuacuucauu gccggcaucg ucuuccggcu gcacuccagc     2460

aauaaaucua gccucuauuc cgggagagug aucuuuuguc uggauuacau uauuuucaca     2520

cugcgccuua uccacaucuu uaccguuagc cggaaccugg gacccaagau uaucaugcuc     2580

cagagaaugc ugauugacgu guucuuuuuc cucuuucugu ucgcugucug gaugguggcg     2640

uuuggcgugg cccgccaagg gauccuuaga cagaaugaac agcgguggcg cuggauuuuc     2700

agaucuguca ucuaugagcc cuaccuggcu auguuuggac agguuccuuc cgauguggac     2760

ggcacgacau augauuucgc ccauugcacc uucacaggga acgagagcaa accgcucugu     2820

guggaacugg acgagcacaa ucugccccgg uuuccugaau ggaucaccau uccccuuguc     2880

ugcaucuaca ugcuguccac caacauucuc cuggugaacc uccugguugc cauguucggc     2940

uacacagugg gaacggucca agagaauaac gaucaggugu ggaaguuuca gcgcuauuuc     3000

cuuguucaag aguacuguuc uagacugaau aucccuuuuc ccuucauugu guuugcuuau     3060

uucuacaugg ucgugaaaaa gugcuuuaag uguugcugua aagaaaagaa cauggagagc     3120

uccguuugcu gcuucaaaaa ugaagacaac gagacccucg ccugggaagg cgugaugaag     3180

gagaauuauc uggucaaaau caacacaaag gcgaaugaua ccucugagga aaugcggcau     3240

cgcuuuagac agcuggacac aaagcugaac gaucugaaag ggcuccugaa ggagauugcu     3300

aauaaaauca aguga                                                      3315


<210>  3702
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSG10__Homo_sapiens__Q9BZW7

<400>  3702

Met Met Arg Ser Arg Ser Lys Ser Pro Arg Arg Pro Ser Pro Thr Ala 
1               5                   10                  15      


Arg Gly Ala Asn Cys Asp Val Glu Leu Leu Lys Thr Thr Thr Arg Asp 
            20                  25                  30          


Arg Glu Glu Leu Lys Cys Met Leu Glu Lys Tyr Glu Arg His Leu Ala 
        35                  40                  45              


Glu Ile Gln Gly Asn Val Lys Val Leu Lys Ser Glu Arg Asp Lys Ile 
    50                  55                  60                  


Phe Leu Leu Tyr Glu Gln Ala Gln Glu Glu Ile Thr Arg Leu Arg Arg 
65                  70                  75                  80  


Glu Met Met Lys Ser Cys Lys Ser Pro Lys Ser Thr Thr Ala His Ala 
                85                  90                  95      


Ile Leu Arg Arg Val Glu Thr Glu Arg Asp Val Ala Phe Thr Asp Leu 
            100                 105                 110         


Arg Arg Met Thr Thr Glu Arg Asp Ser Leu Arg Glu Arg Leu Lys Ile 
        115                 120                 125             


Ala Gln Glu Thr Ala Phe Asn Glu Lys Ala His Leu Glu Gln Arg Ile 
    130                 135                 140                 


Glu Glu Leu Glu Cys Thr Val His Asn Leu Asp Asp Glu Arg Met Glu 
145                 150                 155                 160 


Gln Met Ser Asn Met Thr Leu Met Lys Glu Thr Ile Ser Thr Val Glu 
                165                 170                 175     


Lys Glu Met Lys Ser Leu Ala Arg Lys Ala Met Asp Thr Glu Ser Glu 
            180                 185                 190         


Leu Gly Arg Gln Lys Ala Glu Asn Asn Ser Leu Arg Leu Leu Tyr Glu 
        195                 200                 205             


Asn Thr Glu Lys Asp Leu Ser Asp Thr Gln Arg His Leu Ala Lys Lys 
    210                 215                 220                 


Lys Tyr Glu Leu Gln Leu Thr Gln Glu Lys Ile Met Cys Leu Asp Glu 
225                 230                 235                 240 


Lys Ile Asp Asn Phe Thr Arg Gln Asn Ile Ala Gln Arg Glu Glu Ile 
                245                 250                 255     


Ser Ile Leu Gly Gly Thr Leu Asn Asp Leu Ala Lys Glu Lys Glu Cys 
            260                 265                 270         


Leu Gln Ala Cys Leu Asp Lys Lys Ser Glu Asn Ile Ala Ser Leu Gly 
        275                 280                 285             


Glu Ser Leu Ala Met Lys Glu Lys Thr Ile Ser Gly Met Lys Asn Ile 
    290                 295                 300                 


Ile Ala Glu Met Glu Gln Ala Ser Arg Gln Cys Thr Glu Ala Leu Ile 
305                 310                 315                 320 


Val Cys Glu Gln Asp Val Ser Arg Met Arg Arg Gln Leu Asp Glu Thr 
                325                 330                 335     


Asn Asp Glu Leu Ala Gln Ile Ala Arg Glu Arg Asp Ile Leu Ala His 
            340                 345                 350         


Asp Asn Asp Asn Leu Gln Glu Gln Phe Ala Lys Ala Lys Gln Glu Asn 
        355                 360                 365             


Gln Ala Leu Ser Lys Lys Leu Asn Asp Thr His Asn Glu Leu Asn Asp 
    370                 375                 380                 


Ile Lys Gln Lys Val Gln Asp Thr Asn Leu Glu Val Asn Lys Leu Lys 
385                 390                 395                 400 


Asn Ile Leu Lys Ser Glu Glu Ser Glu Asn Arg Gln Met Met Glu Gln 
                405                 410                 415     


Leu Arg Lys Ala Asn Glu Asp Ala Glu Asn Trp Glu Asn Lys Ala Arg 
            420                 425                 430         


Gln Ser Glu Ala Asp Asn Asn Thr Leu Lys Leu Glu Leu Ile Thr Ala 
        435                 440                 445             


Glu Ala Glu Gly Asn Arg Leu Lys Glu Lys Val Asp Ser Leu Asn Arg 
    450                 455                 460                 


Glu Val Glu Gln His Leu Asn Ala Glu Arg Ser Tyr Lys Ser Gln Ile 
465                 470                 475                 480 


Ser Thr Leu His Lys Ser Val Val Lys Met Glu Glu Glu Leu Gln Lys 
                485                 490                 495     


Val Gln Phe Glu Lys Val Ser Ala Leu Ala Asp Leu Ser Ser Thr Arg 
            500                 505                 510         


Glu Leu Cys Ile Lys Leu Asp Ser Ser Lys Glu Leu Leu Asn Arg Gln 
        515                 520                 525             


Leu Val Ala Lys Asp Gln Glu Ile Glu Met Arg Glu Asn Glu Leu Asp 
    530                 535                 540                 


Ser Ala His Ser Glu Ile Glu Leu Leu Arg Ser Gln Met Ala Asn Glu 
545                 550                 555                 560 


Arg Ile Ser Met Gln Asn Leu Glu Ala Leu Leu Val Ala Asn Arg Asp 
                565                 570                 575     


Lys Glu Tyr Gln Ser Gln Ile Ala Leu Gln Glu Lys Glu Ser Glu Ile 
            580                 585                 590         


Gln Leu Leu Lys Glu His Leu Cys Leu Ala Glu Asn Lys Met Ala Ile 
        595                 600                 605             


Gln Ser Arg Asp Val Ala Gln Phe Arg Asn Val Val Thr Gln Leu Glu 
    610                 615                 620                 


Ala Asp Leu Asp Ile Thr Lys Arg Gln Leu Gly Thr Glu Arg Phe Glu 
625                 630                 635                 640 


Arg Glu Arg Ala Val Gln Glu Leu Arg Arg Gln Asn Tyr Ser Ser Asn 
                645                 650                 655     


Ala Tyr His Met Ser Ser Thr Met Lys Pro Asn Thr Lys Cys His Ser 
            660                 665                 670         


Pro Glu Arg Ala His His Arg Ser Pro Asp Arg Gly Leu Asp Arg Ser 
        675                 680                 685             


Leu Glu Glu Asn Leu Cys Tyr Arg Asp Phe 
    690                 695             


<210>  3703
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TSG10__Homo_sapiens__AAK13079

<400>  3703
augaugcgaa guaggucuaa aaguccaaga cgcccaucac caacugcccg gggugcaaac       60

ugugauguag aacuuuugaa gacaacaaca agagaucgug aagaacuuaa augcaugcug      120

gaaaaauaug agcgccauuu ggcagaaauu caggguaaug ucaagguucu uaaaucugag      180

agagacaaga ucuuccuucu uuaugaacag gcacaggaag aaauuacccg acuucgacga      240

gaaaugauga aaagcuguaa gaguccuaaa ucaacaacgg cacaugcuau ucuccggcga      300

guggagacug aaagagaugu agccuuuacu gauuuacgaa gaaugaccac agaacgagau      360

agucuaaggg agaggcuaaa gauugcucaa gagacagcau uuaaugagaa ggcucaccug      420

gaacaaagga uagaggagcu ggaguguaca guucauaauc uugaugauga acguauggag      480

caaaugucaa auaugacuuu gaugaaggaa accauaagca cuguggaaaa agaaaugaaa      540

ucacuagcaa gaaaggcaau ggauaccgaa agugaacuug gcagacaaaa agcagagaau      600

aauucuuuga gacuuuugua ugaaaacaca gaaaaagauc uuucugauac ucagcgacac      660

cuugcuaaga aaaaauauga gcuacagcuu acucaggaga aaauuaugug cuuggaugaa      720

aaaauugaua acuuuacaag gcaaaauauu gcacagcgag aagaaaucag cauucuuggu      780

ggaacccuca augaucuggc uaaagaaaag gaaugccugc aagcauguuu ggauaaaaaa      840

ucugagaaua uugcaucccu uggagagagu uuggcaauga aagaaaagac cauuucaggc      900

augaagaaua ucauugcuga gauggaacag gcaucaagac aguguacuga ggcccuaauu      960

gugugugaac aagacguuuc cagaaugcgu cggcaauugg augagacaaa ugaugagcug     1020

gcccagaucg ccagggaaag agauaucuug gcucaugaca augacaaucu ccaggaacag     1080

uuugcuaaag cuaaacaaga aaaccaggca cuguccaaaa aauugaauga cacucauaau     1140

gaacuuaaug acauaaaaca gaagguucaa gauacuaauu uggagguuaa caagcugaag     1200

aauauauuaa agucugaaga aucugagaac cggcaaauga uggaacaacu ucgaaaagcc     1260

aaugaagaug cugaaaacug ggaaaauaaa gcccgucaau cagaggcaga uaacaauacc     1320

cucaaacugg aacuuaucac ugcugaggca gaggguaaca gauuaaaaga aaaaguagau     1380

ucccucaaca gagagguuga gcaacacuua aaugcagaaa ggucuuacaa gucccagauu     1440

ucuaccuuac auaaaucugu uguaaaaaug gaagaggagc uucagaaggu ucaguuugaa     1500

aaaguguccg cucuugcaga uuugucuucu acuagggaac ucuguauuaa acuugacuca     1560

agcaaagaac uucuuaaucg acagcugguu gcuaaagauc aagaaauaga aaugagggag     1620

aaugaguuag auucugcuca uucugaaauu gaacuccuga ggagucagau ggcaaaugag     1680

agaaucucca ugcagaaucu agaagcuuug cugguggcca aucgagacaa agaauaucag     1740

ucucagauag cacuucaaga aaaagaaucu gaaauucagc uucuuaaaga acaccuuugu     1800

uuggcagaaa auaaaauggc cauccagagu agagaugugg cccaguucag aaauguuguc     1860

acacaauugg aagcugauuu agacauuacc aaaagacaac uaggaacaga gcgcuuugaa     1920

agggagaggg ccguacaaga acuucgccgc caaaauuauu caaguaaugc uuaucauaug     1980

aguucuacaa ugaagccaaa uacaaaaugu cauucaccag aacgugcuca ccaucgaucu     2040

ccugaccgag gccuagaucg aucauuagaa gagaaucuuu gcuacagaga uuucuga        2097


<210>  3704
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TSG10__Homo_sapiens__AAK13079

<400>  3704
augaugcgca gccgguccaa gagcccccgc cggccguccc ccaccgcccg cggcgccaac       60

ugcgacgugg agcugcucaa gaccacgacc cgggaccgcg aggagcugaa gugcaugcug      120

gagaaguacg agcggcaccu cgcggagauc caggggaacg ucaaggugcu caagagcgag      180

cgcgacaaga ucuuccugcu guacgagcag gcccaggagg agaucacccg gcugcgccgg      240

gagaugauga aguccugcaa gagccccaag uccaccacgg cccacgccau ccugcgccgg      300

guggagaccg agcgcgacgu cgccuucacc gaccuccggc gcaugaccac ggagcgggac      360

agccugcgcg agcggcugaa gaucgcgcag gagaccgccu ucaacgagaa ggcccaccuc      420

gagcagcgca ucgaggagcu ggagugcacc gugcacaacc uggacgacga gcggauggag      480

cagaugucca acaugacccu caugaaggag acgaucagca ccguggagaa ggagaugaag      540

ucccuggccc gcaaggcgau ggacaccgag agcgagcugg gccgccagaa ggccgagaac      600

aacucccucc ggcugcugua cgagaacacc gagaaggacc ucagcgacac gcagcgccac      660

cuggccaaga agaaguacga gcugcagcuc acccaggaga agaucaugug ccuggacgag      720

aagaucgaca acuucacccg gcagaacauc gcccagcgcg aggagaucuc cauccucggg      780

ggcacccuga acgaccuggc caaggagaag gagugccugc aggcgugccu cgacaagaag      840

uccgagaaca ucgccagccu gggggagagc cuggccauga aggagaagac gaucuccggc      900

augaagaaca ucaucgccga gauggagcag gccagccggc agugcaccga ggcgcucauc      960

gucugcgagc aggacgugag ccgcaugcgg cgccagcugg acgagaccaa cgacgagcug     1020

gcccagaucg cccgggagcg cgacauccuc gcccacgaca acgacaaccu gcaggagcag     1080

uucgccaagg cgaagcagga gaaccaggcc cuguccaaga agcucaacga cacccacaac     1140

gagcugaacg acaucaagca gaaggugcag gacacgaacc uggaggucaa caagcucaag     1200

aacauccuca agagcgagga guccgagaac cggcagauga uggagcagcu gcgcaaggcc     1260

aacgaggacg ccgagaacug ggagaacaag gcccggcaga gcgaggcgga caacaacacc     1320

cugaagcugg agcugaucac cgccgaggcc gagggcaacc gccucaagga gaagguggac     1380

ucccugaacc gggaggugga gcagcaccug aacgccgagc gcagcuacaa gucccagauc     1440

agcacccugc acaaguccgu cgugaagaug gaggaggagc uccagaaggu gcaguucgag     1500

aaggucagcg cgcuggccga ccuguccagc acgcgggagc ucugcaucaa gcuggacucc     1560

agcaaggagc ugcucaaccg ccagcuggug gccaaggacc aggagaucga gaugcgggag     1620

aacgagcugg acuccgccca cagcgagauc gagcuccugc gcucccagau ggccaacgag     1680

cgcaucagca ugcagaaccu ggaggcgcuc cugguggcca accgggacaa ggaguaccag     1740

ucccagaucg cccugcagga gaaggagagc gagauccagc uccugaagga gcaccugugc     1800

cucgccgaga acaagauggc cauccagagc cgcgacgucg cgcaguuccg gaacguggug     1860

acccagcugg aggccgaccu ggacaucacc aagcgccagc ucgggaccga gcgguucgag     1920

cgcgagcggg ccguccagga gcugcgccgg cagaacuacu ccagcaacgc cuaccacaug     1980

uccagcacga ugaagcccaa caccaagugc cacuccccgg agcgcgccca ccaccggagc     2040

cccgaccgcg gccuggaccg gucccucgag gagaaccugu gcuaccgcga cuucuga        2097


<210>  3705
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TSG10__Homo_sapiens__AAK13079

<400>  3705
augaugcgcu cccgcuccaa guccccccgc cgccccuccc ccaccgcccg cggcgccaac       60

ugcgacgucg agcuccucaa gaccaccacc cgcgaccgcg aggagcucaa gugcaugcuc      120

gagaaguacg agcgccaccu cgccgagauc cagggcaacg ucaagguccu caaguccgag      180

cgcgacaaga ucuuccuccu cuacgagcag gcccaggagg agaucacccg ccuccgccgc      240

gagaugauga aguccugcaa gucccccaag uccaccaccg cccacgccau ccuccgccgc      300

gucgagaccg agcgcgacgu cgccuucacc gaccuccgcc gcaugaccac cgagcgcgac      360

ucccuccgcg agcgccucaa gaucgcccag gagaccgccu ucaacgagaa ggcccaccuc      420

gagcagcgca ucgaggagcu cgagugcacc guccacaacc ucgacgacga gcgcauggag      480

cagaugucca acaugacccu caugaaggag accaucucca ccgucgagaa ggagaugaag      540

ucccucgccc gcaaggccau ggacaccgag uccgagcucg gccgccagaa ggccgagaac      600

aacucccucc gccuccucua cgagaacacc gagaaggacc ucuccgacac ccagcgccac      660

cucgccaaga agaaguacga gcuccagcuc acccaggaga agaucaugug ccucgacgag      720

aagaucgaca acuucacccg ccagaacauc gcccagcgcg aggagaucuc cauccucggc      780

ggcacccuca acgaccucgc caaggagaag gagugccucc aggccugccu cgacaagaag      840

uccgagaaca ucgccucccu cggcgagucc cucgccauga aggagaagac caucuccggc      900

augaagaaca ucaucgccga gauggagcag gccucccgcc agugcaccga ggcccucauc      960

gucugcgagc aggacgucuc ccgcaugcgc cgccagcucg acgagaccaa cgacgagcuc     1020

gcccagaucg cccgcgagcg cgacauccuc gcccacgaca acgacaaccu ccaggagcag     1080

uucgccaagg ccaagcagga gaaccaggcc cucuccaaga agcucaacga cacccacaac     1140

gagcucaacg acaucaagca gaagguccag gacaccaacc ucgaggucaa caagcucaag     1200

aacauccuca aguccgagga guccgagaac cgccagauga uggagcagcu ccgcaaggcc     1260

aacgaggacg ccgagaacug ggagaacaag gcccgccagu ccgaggccga caacaacacc     1320

cucaagcucg agcucaucac cgccgaggcc gagggcaacc gccucaagga gaaggucgac     1380

ucccucaacc gcgaggucga gcagcaccuc aacgccgagc gcuccuacaa gucccagauc     1440

uccacccucc acaaguccgu cgucaagaug gaggaggagc uccagaaggu ccaguucgag     1500

aaggucuccg cccucgccga ccucuccucc acccgcgagc ucugcaucaa gcucgacucc     1560

uccaaggagc uccucaaccg ccagcucguc gccaaggacc aggagaucga gaugcgcgag     1620

aacgagcucg acuccgccca cuccgagauc gagcuccucc gcucccagau ggccaacgag     1680

cgcaucucca ugcagaaccu cgaggcccuc cucgucgcca accgcgacaa ggaguaccag     1740

ucccagaucg cccuccagga gaaggagucc gagauccagc uccucaagga gcaccucugc     1800

cucgccgaga acaagauggc cauccagucc cgcgacgucg cccaguuccg caacgucguc     1860

acccagcucg aggccgaccu cgacaucacc aagcgccagc ucggcaccga gcgcuucgag     1920

cgcgagcgcg ccguccagga gcuccgccgc cagaacuacu ccuccaacgc cuaccacaug     1980

uccuccacca ugaagcccaa caccaagugc cacucccccg agcgcgccca ccaccgcucc     2040

cccgaccgcg gccucgaccg cucccucgag gagaaccucu gcuaccgcga cuucuga        2097


<210>  3706
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TSG10__Homo_sapiens__AAK13079

<400>  3706
augaugagaa gcagguccaa gucuccccgg cgcccuucac caaccgcccg aggcgcuaac       60

ugcgacgugg agcugcucaa aacaacuacg cgugauagag aggaacuuaa guguaugcug      120

gaaaaauacg agaggcacuu ggcagaaauc caggggaaug ucaagguuuu aaaaagugag      180

cgggacaaga uuuuccugcu auaugagcaa gcccaggaag agauaacccg ccucagaagg      240

gaaaugauga aguccugcaa auccccgaag ucuacaacug cgcaugcuau ccugcggcgc      300

guggagaccg agcgagaugu agccuuuaca gaccuuagaa ggaugaccac ugaacgggau      360

ucgcugcgug agcgcuugaa aauugcacag gaaacagccu ucaacgagaa ggcucaccuc      420

gaacagagaa ucgaggagcu ggaauguacc gugcauaauc uggacgauga gaggauggaa      480

caaaugucaa acaugacgcu caugaaagag acuauuagca ccgucgaaaa ggagaugaag      540

aguuuagcac ggaaagccau ggacacagag uccgaacugg gacgacagaa ggcugagaau      600

aacucucuuc gcuugcugua cgaaaauacu gagaaagauc uaagcgacac ccagagacac      660

cucgccaaga aaaaguauga acugcagcuu acacaagaga aaaucaugug ccuggaugag      720

aagauagaca acuuuaccag gcagaauauc gcgcagcggg aagagauuuc caucuugggu      780

ggcacgcuca acgaucuggc aaaggaaaaa gaguguuuac aggccugccu ggacaagaaa      840

ucagagaaua uugcuagucu cggggaaagc cuugccauga aggagaaaac uaucucugga      900

augaagaaca uaauugcaga aauggagcaa gcuagccgcc aguguacaga agcccugauc      960

gugugcgagc aggacguuuc aagaaugagg cgucaauugg augagaccaa ugacgaacua     1020

gcgcagauug cccgggagcg agauauccug gcacaugaca acgauaaucu ccaggaacag     1080

uucgcuaagg ccaaacaaga gaaccaggcu cugagcaaga aacuuaacga cacucacaau     1140

gaacugaacg auaucaagca gaaagugcag gacacaaauu uggaggucaa caagcucaag     1200

aauauucuga aaagugagga aucugagaac agacaaauga uggaacaguu aaggaaggcc     1260

aaugaggaug cagaaaacug ggagaauaaa gcccgccagu ccgaggcuga caacaauacc     1320

cugaagcuag aacucauaac ggcggaggca gaaggcaacc ggcugaaaga gaagguggau     1380

agccuuaaua gagagguaga acagcacuug aacgccgaga ggucguacaa gucucaaauc     1440

uccacccugc auaaaucagu ugugaagaug gaagaggaac uccagaaagu ccaguuugag     1500

aaggugagug cucuggccga ccuuagcucc acacgcgagc uguguauuaa auuggacucu     1560

agcaaggaac uccugaaucg acaguuagug gcaaaagauc aagagaucga aaugcgggag     1620

aacgaacugg acucagccca cagugagaua gagcuacucc guucccagau ggcuaacgaa     1680

agaauuagca ugcagaaucu ggaggcccuu uuggucgcaa acagggauaa ggaauaucaa     1740

ucucagaucg cgcugcagga gaaggaauca gagauccagc uccugaaaga gcauuuaugc     1800

cuggcugaaa auaagauggc cauucaaagu cgcgacguug cacaguuccg gaacguggua     1860

acucagcuug aggccgauuu ggacaucacc aaaagacagc ucgguacaga aagguuugag     1920

cgagagcgcg cugugcaaga acugcggaga cagaauuaca gcuccaacgc cuaucacaug     1980

ucuucgacua ugaagcccaa uaccaaaugu cacagcccug agagggcaca ucaccguucc     2040

ccagaucgcg ggcuagaccg gucacuggaa gagaaccucu gcuacagaga uuucuga        2097


<210>  3707
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TSG10__Homo_sapiens__AAK13079

<400>  3707
augaugagaa gcagaagcaa gagccccaga agacccagcc ccaccgccag aggcgccaac       60

ugcgacgugg agcugcugaa gaccaccacc agagacagag aggagcugaa gugcaugcug      120

gagaaguacg agagacaccu ggccgagauc cagggcaacg ugaaggugcu gaagagcgag      180

agagacaaga ucuuccugcu guacgagcag gcccaggagg agaucaccag acugagaaga      240

gagaugauga agagcugcaa gagccccaag agcaccaccg cccacgccau ccugagaaga      300

guggagaccg agagagacgu ggccuucacc gaccugagaa gaaugaccac cgagagagac      360

agccugagag agagacugaa gaucgcccag gagaccgccu ucaacgagaa ggcccaccug      420

gagcagagaa ucgaggagcu ggagugcacc gugcacaacc uggacgacga gagaauggag      480

cagaugagca acaugacccu gaugaaggag accaucagca ccguggagaa ggagaugaag      540

agccuggcca gaaaggccau ggacaccgag agcgagcugg gcagacagaa ggccgagaac      600

aacagccuga gacugcugua cgagaacacc gagaaggacc ugagcgacac ccagagacac      660

cuggccaaga agaaguacga gcugcagcug acccaggaga agaucaugug ccuggacgag      720

aagaucgaca acuucaccag acagaacauc gcccagagag aggagaucag cauccugggc      780

ggcacccuga acgaccuggc caaggagaag gagugccugc aggccugccu ggacaagaag      840

agcgagaaca ucgccagccu gggcgagagc cuggccauga aggagaagac caucagcggc      900

augaagaaca ucaucgccga gauggagcag gccagcagac agugcaccga ggcccugauc      960

gugugcgagc aggacgugag cagaaugaga agacagcugg acgagaccaa cgacgagcug     1020

gcccagaucg ccagagagag agacauccug gcccacgaca acgacaaccu gcaggagcag     1080

uucgccaagg ccaagcagga gaaccaggcc cugagcaaga agcugaacga cacccacaac     1140

gagcugaacg acaucaagca gaaggugcag gacaccaacc uggaggugaa caagcugaag     1200

aacauccuga agagcgagga gagcgagaac agacagauga uggagcagcu gagaaaggcc     1260

aacgaggacg ccgagaacug ggagaacaag gccagacaga gcgaggccga caacaacacc     1320

cugaagcugg agcugaucac cgccgaggcc gagggcaaca gacugaagga gaagguggac     1380

agccugaaca gagaggugga gcagcaccug aacgccgaga gaagcuacaa gagccagauc     1440

agcacccugc acaagagcgu ggugaagaug gaggaggagc ugcagaaggu gcaguucgag     1500

aaggugagcg cccuggccga ccugagcagc accagagagc ugugcaucaa gcuggacagc     1560

agcaaggagc ugcugaacag acagcuggug gccaaggacc aggagaucga gaugagagag     1620

aacgagcugg acagcgccca cagcgagauc gagcugcuga gaagccagau ggccaacgag     1680

agaaucagca ugcagaaccu ggaggcccug cugguggcca acagagacaa ggaguaccag     1740

agccagaucg cccugcagga gaaggagagc gagauccagc ugcugaagga gcaccugugc     1800

cuggccgaga acaagauggc cauccagagc agagacgugg cccaguucag aaacguggug     1860

acccagcugg aggccgaccu ggacaucacc aagagacagc ugggcaccga gagauucgag     1920

agagagagag ccgugcagga gcugagaaga cagaacuaca gcagcaacgc cuaccacaug     1980

agcagcacca ugaagcccaa caccaagugc cacagccccg agagagccca ccacagaagc     2040

cccgacagag gccuggacag aagccuggag gagaaccugu gcuacagaga cuucuga        2097


<210>  3708
<211>  2097
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TSG10__Homo_sapiens__AAK13079

<400>  3708
augaugagaa gccgguccaa gucuccccgc agaccuagcc cgaccgcccg gggcgcuaac       60

ugcgacgugg agcugcucaa aacaacgacc cgcgauagag aggaacugaa guguaugcuu      120

gaaaaauacg agcggcaccu ggccgaaauc caggggaaug ucaagguucu caaauccgag      180

cgcgacaaga uuuuccugcu uuaugagcaa gcgcaggaag agaucacaag acugcggcgc      240

gaaaugauga agucuugcaa aagccccaag uccaccacag cucaugccau ucucagacgg      300

guggagaccg agcgcgaugu ggccuuuaca gaccugagac ggaugaccac ggaacgcgau      360

ucucugagag agcggcucaa aaucgcucag gaaaccgccu ucaacgagaa ggcucaccug      420

gaacagagaa uugaggagcu ugaauguaca guccauaauc uggacgauga gcgcauggaa      480

caaaugagca acaugacccu caugaaagag acaaucucca ccguggaaaa ggagaugaaa      540

agccuggccc ggaaggcgau ggacacggag ucugaacuug gaagacagaa ggccgagaau      600

aacucccugc gccuccugua cgaaaauaca gagaaagauc ugagcgacac ccagcggcac      660

cucgcuaaga aaaaguauga acugcagcuu acacaagaga aaaucaugug ccuggaugag      720

aagauugaca acuuuaccag acagaauauc gcccagcgcg aagagauuuc uauccucggc      780

gggacccuga acgaucuugc uaaggaaaaa gagugucugc aggccugccu cgacaagaaa      840

uccgagaaua uugcgagccu gggagaaucu cuggccauga aggagaaaac aaucuccggc      900

augaagaaca uuaucgcuga aauggagcaa gccagccggc aguguacgga agcucucauc      960

guuugcgagc aggacguguc cagaaugcgc cggcaacugg augagaccaa ugacgaacuu     1020

gcccagauug ccagagagcg cgauauccug gcucaugaca acgauaaucu ccaggaacag     1080

uucgcgaagg ccaaacaaga gaaccaggcu cugucuaaga aacuuaacga cacacacaau     1140

gaacugaacg auauuaagca gaaaguccag gacaccaauc ucgaggugaa caagcugaag     1200

aauauccuga aaagcgagga auccgagaac cggcaaauga uggaacagcu cagaaaggcc     1260

aaugaggaug ccgaaaacug ggagaauaaa gcucggcaga gcgaggccga caacaauaca     1320

cugaaacuug aacugauuac cgcggaggcu gaagggaacc gccucaagga gaagguugau     1380

ucucugaaua gagaggugga acagcaccug aacgccgagc gguccuacaa gagccaaauc     1440

ucuacgcuuc auaaaagcgu cgugaagaug gaagaggaac uccagaaagu gcaguuugag     1500

aaggucuccg cccuggcuga ccugucuagc acaagagagc ucuguaucaa acuggacucc     1560

agcaaggaac uucugaaucg ccagcucguu gccaaagauc aagagauuga aaugcgggag     1620

aacgaacugg acucugcuca cuccgagauc gagcugcuua gaagccagau ggccaacgaa     1680

cgcauuucua ugcagaaucu cgaggcgcug cugguggcca acagagauaa ggaauaucaa     1740

ucccagaucg cucuccagga gaaggaaagc gagauucagc ugcuuaaaga gcaucugugc     1800

cucgccgaaa auaagauggc uauccaaucc cgggacgugg cccaguuccg caacgucgug     1860

acccagcugg aggcggaucu ggacaucacc aaaagacagc uuggaacaga acgguuugag     1920

cgcgagagag ccguucaaga acuccggcgc cagaauuacu cuagcaacgc uuaucacaug     1980

uccucuacca ugaagccuaa uacaaaaugu cacagccccg agagagccca ucaccggucc     2040

ccugaucgcg gccuggacag aagccuggaa gagaaccucu gcuaccggga uuucuga        2097


<210>  3709
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSPY1__Homo_sapiens__Q01534

<400>  3709

Met Arg Pro Glu Gly Ser Leu Thr Tyr Arg Val Pro Glu Arg Leu Arg 
1               5                   10                  15      


Gln Gly Phe Cys Gly Val Gly Arg Ala Ala Gln Ala Leu Val Cys Ala 
            20                  25                  30          


Ser Ala Lys Glu Gly Thr Ala Phe Arg Met Glu Ala Val Gln Glu Gly 
        35                  40                  45              


Ala Ala Gly Val Glu Ser Glu Gln Ala Ala Leu Gly Glu Glu Ala Val 
    50                  55                  60                  


Leu Leu Leu Asp Asp Ile Met Ala Glu Val Glu Val Val Ala Glu Glu 
65                  70                  75                  80  


Glu Gly Leu Val Glu Arg Arg Glu Glu Ala Gln Arg Ala Gln Gln Ala 
                85                  90                  95      


Val Pro Gly Pro Gly Pro Met Thr Pro Glu Ser Ala Pro Glu Glu Leu 
            100                 105                 110         


Leu Ala Val Gln Val Glu Leu Glu Pro Val Asn Ala Gln Ala Arg Lys 
        115                 120                 125             


Ala Phe Ser Arg Gln Arg Glu Lys Met Glu Arg Arg Arg Lys Pro His 
    130                 135                 140                 


Leu Asp Arg Arg Gly Ala Val Ile Gln Ser Val Pro Gly Phe Trp Ala 
145                 150                 155                 160 


Asn Val Ile Ala Asn His Pro Gln Met Ser Ala Leu Ile Thr Asp Glu 
                165                 170                 175     


Asp Glu Asp Met Leu Ser Tyr Met Val Ser Leu Glu Val Gly Glu Glu 
            180                 185                 190         


Lys His Pro Val His Leu Cys Lys Ile Met Leu Phe Phe Arg Ser Asn 
        195                 200                 205             


Pro Tyr Phe Gln Asn Lys Val Ile Thr Lys Glu Tyr Leu Val Asn Ile 
    210                 215                 220                 


Thr Glu Tyr Arg Ala Ser His Ser Thr Pro Ile Glu Trp Tyr Pro Asp 
225                 230                 235                 240 


Tyr Glu Val Glu Ala Tyr Arg Arg Arg His His Asn Ser Ser Leu Asn 
                245                 250                 255     


Phe Phe Asn Trp Phe Ser Asp His Asn Phe Ala Gly Ser Asn Lys Ile 
            260                 265                 270         


Ala Glu Ile Leu Cys Lys Asp Leu Trp Arg Asn Pro Leu Gln Tyr Tyr 
        275                 280                 285             


Lys Arg Met Lys Pro Pro Glu Glu Gly Thr Glu Thr Ser Gly Asp Ser 
    290                 295                 300                 


Gln Leu Leu Ser 
305             


<210>  3710
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TSPY1__Homo_sapiens__CCDS48205.1

<400>  3710
augcgcccug agggcucgcu gaccuaccgg gugccagaga ggcugcggca ggguuucugu       60

ggcguggguc gggcagcaca ggccuuggug ugugcgagug ccaaggaggg caccgccuuc      120

aggauggagg cugugcagga gggggcggcc gggguggaga gugagcaggc ggcuuugggg      180

gaggaggcgg ugcugcuguu ggaugacaua auggcggagg uggagguggu ggcggaggag      240

gagggccucg uggagcggcg ggaggaggcc cagcgggcac agcaggcugu gccuggcccu      300

gggcccauga ccccagaguc ugcaccggag gagcugcugg ccguucaggu ggagcuggag      360

ccgguuaaug cccaagccag gaaggccuuu ucucggcagc gggaaaagau ggagcggagg      420

cgcaagcccc accuagaccg cagaggcgcc gucauccaga gcgucccugg cuucugggcc      480

aauguuauug caaaccaccc ccagauguca gcccugauca cugacgaaga ugaagacaug      540

cugagcuaca uggucagccu ggagguggga gaagagaagc auccuguuca ucucugcaag      600

aucauguugu ucuuucggag uaaccccuac uuccagaaua aagugauuac caaggaauau      660

cuggugaaca ucacagaaua cagggcuucu cauuccacuc caauugagug guauccggau      720

uaugaagugg aggccuaucg ccgcagacac cacaacagca gccuuaacuu cuucaacugg      780

uucucugacc acaacuucgc aggaucuaac aagauugcug agauccuaug uaaggaccug      840

uggcgcaauc cccugcaaua cuacaagagg augaagccac cugaagaggg aacagagacg      900

ucaggggacu cccaguuguu gaguuga                                          927


<210>  3711
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TSPY1__Homo_sapiens__CCDS48205.1

<400>  3711
augcgccccg agggcagccu gaccuaccgg gugccggagc gccuccggca gggguucugc       60

ggcgucgggc gcgccgccca ggcgcuggug ugcgccuccg ccaaggaggg caccgccuuc      120

cggauggagg ccgugcagga gggggcggcc ggcgucgaga gcgagcaggc cgcccugggc      180

gaggaggcgg ugcuccugcu ggacgacauc auggccgagg uggaggucgu ggccgaggag      240

gaggggcucg uggagcgccg ggaggaggcc cagcgcgccc agcaggcggu ccccggcccc      300

gggcccauga cgccggaguc cgcccccgag gagcugcugg ccguccaggu ggagcucgag      360

cccgugaacg cccaggcccg gaaggcguuc agccgccagc gggagaagau ggagcgccgg      420

cgcaagcccc accuggaccg gcgcggcgcc gugauccagu ccgugccggg guucugggcc      480

aacgucaucg ccaaccaccc ccagaugagc gcccugauca ccgacgagga cgaggacaug      540

cucuccuaca uggugagccu ggaggugggc gaggagaagc accccgucca ccugugcaag      600

aucaugcugu ucuuccgguc caaccccuac uuccagaaca aggugaucac caaggaguac      660

cucgugaaca ucaccgagua ccgcgcgagc cacuccacgc cgaucgagug guaccccgac      720

uacgaggucg aggccuaccg gcgccggcac cacaacagcu cccugaacuu cuucaacugg      780

uucagcgacc acaacuucgc cggcuccaac aagaucgccg agauccucug caaggaccug      840

uggcgcaacc cccugcagua cuacaagcgc augaagcccc cggaggaggg gaccgagacc      900

agcggcgacu cccagcuccu gagcuga                                          927


<210>  3712
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TSPY1__Homo_sapiens__CCDS48205.1

<400>  3712
augcgccccg agggcucccu caccuaccgc guccccgagc gccuccgcca gggcuucugc       60

ggcgucggcc gcgccgccca ggcccucguc ugcgccuccg ccaaggaggg caccgccuuc      120

cgcauggagg ccguccagga gggcgccgcc ggcgucgagu ccgagcaggc cgcccucggc      180

gaggaggccg uccuccuccu cgacgacauc auggccgagg ucgaggucgu cgccgaggag      240

gagggccucg ucgagcgccg cgaggaggcc cagcgcgccc agcaggccgu ccccggcccc      300

ggccccauga cccccgaguc cgcccccgag gagcuccucg ccguccaggu cgagcucgag      360

cccgucaacg cccaggcccg caaggccuuc ucccgccagc gcgagaagau ggagcgccgc      420

cgcaagcccc accucgaccg ccgcggcgcc gucauccagu ccguccccgg cuucugggcc      480

aacgucaucg ccaaccaccc ccagaugucc gcccucauca ccgacgagga cgaggacaug      540

cucuccuaca uggucucccu cgaggucggc gaggagaagc accccgucca ccucugcaag      600

aucaugcucu ucuuccgcuc caaccccuac uuccagaaca aggucaucac caaggaguac      660

cucgucaaca ucaccgagua ccgcgccucc cacuccaccc ccaucgagug guaccccgac      720

uacgaggucg aggccuaccg ccgccgccac cacaacuccu cccucaacuu cuucaacugg      780

uucuccgacc acaacuucgc cggcuccaac aagaucgccg agauccucug caaggaccuc      840

uggcgcaacc cccuccagua cuacaagcgc augaagcccc ccgaggaggg caccgagacc      900

uccggcgacu cccagcuccu cuccuga                                          927


<210>  3713
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TSPY1__Homo_sapiens__CCDS48205.1

<400>  3713
augagacccg agggcagccu gaccuacagg gugccugaac ggcuccgcca gggguucugc       60

ggagucgguc gagccgcuca agcacuuguu ugugccuccg cgaaggaggg cacagcuuuu      120

cguauggaag ccgugcagga gggggcagcc ggaguagaau cugagcaggc ugcacugggc      180

gaggaagccg uguuguuacu ggacgauauc auggcugagg ucgaaguggu ugccgaggag      240

gaaggucuag uggagagaag ggaagaggcg cagcgggcac aacaggccgu cccagggccg      300

ggacccauga cuccugaauc agcuccagag gagcuccugg ccgugcaggu agaacuugag      360

cccguuaacg cacaggcucg caaagccuuc aguagacaaa gggaaaagau ggagcggcgc      420

cgaaaaccuc accuggacag aaggggcgcg gugauucaga gcgucccagg cuuuugggcc      480

aaugugauag caaaccaucc ccagaugucc gcuuugauca cggaugaaga cgaggauaug      540

cucucuuaua uggugucgcu ggaggucggg gaagagaagc acccuguuca ucugugcaaa      600

auuauguuau ucuuucgguc aaauccauac uuccagaaca aggugaucac caaggaauau      660

cucguaaaua uuacagagua ccgugccagc cacaguacuc cgaucgaaug guaucccgac      720

uacgaggugg aggcuuaucg cagaaggcau cacaacuccu cucugaacuu uuucaauugg      780

uuuagcgauc acaauuucgc cggauccaac aaaauagcag aaauccuuug uaaggacuug      840

uggcggaauc cucugcaaua cuacaaacga augaagccac ccgaggaagg uaccgagaca      900

ucaggcgaua gucagcuacu cagcuga                                          927


<210>  3714
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TSPY1__Homo_sapiens__CCDS48205.1

<400>  3714
augagacccg agggcagccu gaccuacaga gugcccgaga gacugagaca gggcuucugc       60

ggcgugggca gagccgccca ggcccuggug ugcgccagcg ccaaggaggg caccgccuuc      120

agaauggagg ccgugcagga gggcgccgcc ggcguggaga gcgagcaggc cgcccugggc      180

gaggaggccg ugcugcugcu ggacgacauc auggccgagg uggagguggu ggccgaggag      240

gagggccugg uggagagaag agaggaggcc cagagagccc agcaggccgu gcccggcccc      300

ggccccauga cccccgagag cgcccccgag gagcugcugg ccgugcaggu ggagcuggag      360

cccgugaacg cccaggccag aaaggccuuc agcagacaga gagagaagau ggagagaaga      420

agaaagcccc accuggacag aagaggcgcc gugauccaga gcgugcccgg cuucugggcc      480

aacgugaucg ccaaccaccc ccagaugagc gcccugauca ccgacgagga cgaggacaug      540

cugagcuaca uggugagccu ggaggugggc gaggagaagc accccgugca ccugugcaag      600

aucaugcugu ucuucagaag caaccccuac uuccagaaca aggugaucac caaggaguac      660

cuggugaaca ucaccgagua cagagccagc cacagcaccc ccaucgagug guaccccgac      720

uacgaggugg aggccuacag aagaagacac cacaacagca gccugaacuu cuucaacugg      780

uucagcgacc acaacuucgc cggcagcaac aagaucgccg agauccugug caaggaccug      840

uggagaaacc cccugcagua cuacaagaga augaagcccc ccgaggaggg caccgagacc      900

agcggcgaca gccagcugcu gagcuga                                          927


<210>  3715
<211>  927
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TSPY1__Homo_sapiens__CCDS48205.1

<400>  3715
augagacccg agggcagccu gaccuaccgg gugccugaac gccucagaca gggguucugc       60

ggagucggcc gggccgcuca agcccugguu ugugcguccg cuaaggaggg gacagccuuu      120

cgcauggaag ccgugcagga gggagcugcc ggcguggaau cugagcaggc ugcccuuggg      180

gaggaagcgg uccugcuccu ggacgauauc auggccgagg uggaaguugu ggcugaggag      240

gaaggacuug ucgagagacg ggaagaggcc cagcgcgcuc aacaggccgu gccgggcccc      300

ggcccuauga cgcccgaaag cgcgccugag gagcugcucg ccguucaggu ggaacuggag      360

cccgucaacg cucaggccag aaaagccuuc ucccggcaac gcgaaaagau ggagagacgg      420

cgcaaaccuc accuggacag acgcggggcu gugauucagu cugugccggg auuuugggcc      480

aaugucaucg cuaaccaucc ccagaugagc gcgcucauua ccgaugaaga cgaggauaug      540

cuguccuaua ugguuucucu ugaggugggc gaagagaagc acccugugca ucugugcaaa      600

aucaugcugu ucuuucggag caaucccuac uuccagaaca aggucauuac aaaggaauau      660

cucgugaaua ucaccgagua cagagccucc cacagcacac cuaucgaaug guaucccgac      720

uacgagguug aggcuuaucg gagacgccau cacaacucuu cccuuaacuu uuucaauugg      780

uuuagcgauc acaauuucgc cgggucuaac aaaauugccg aaauccugug uaaggaccuc      840

uggcggaauc cgcugcaaua cuacaaaaga augaagccuc ccgaggaagg aaccgagaca      900

uccggcgaua gccagcugcu cucuuga                                          927


<210>  3716
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3716

Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala Ser 
1               5                   10                  15      


Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Gln 
            20                  25                  30          


Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Thr Asn Thr 
        35                  40                  45              


Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg 
    50                  55                  60                  


Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp Val Leu Glu Ser Gly 
65                  70                  75                  80  


Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser Trp 
                85                  90                  95      


Ile Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Thr Trp Asp Arg Gln Lys Leu Leu 
        115                 120         


<210>  3717
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3717
augcgguggg cccuacuggu gcuucuagcu uuccugucuc cugccaguca gaaaucuucc       60

aacuuggaag ggagaacgaa gucagucacc aggcagacug ggucaucugc ugaaaucacu      120

ugcgaucuua cuguaacaaa uaccuucuac auccacuggu accuacacca ggaggggaag      180

gccccacagc gucuucugua cuaugacguc uccacugcaa gggauguguu ggaaucagga      240

cucaguccag gaaaguauua uacucauaca cccaggaggu ggagcuggau auugagacug      300

caaaaucuaa uugaaaauga uucugggguc uauuacugug ccaccuggga caggcaaaaa      360

uuauuauaa                                                              369


<210>  3718
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3718
augcgcuggg cccugcucgu gcugcuggcc uuccucagcc ccgcguccca gaaguccagc       60

aaccuggagg gccggaccaa gagcgucacc cgccagacgg gguccagcgc cgagaucacg      120

ugcgaccuga ccgugaccaa caccuucuac auccacuggu accuccacca ggagggcaag      180

gccccgcagc ggcugcugua cuacgacgug uccaccgccc gcgacguccu cgagagcggg      240

cugucccccg gcaaguacua cacccacacg ccccggcgcu ggagcuggau ccugcggcuc      300

cagaaccuga ucgagaacga cuccggggug uacuacugcg ccaccuggga ccgccagaag      360

cugcucuga                                                              369


<210>  3719
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3719
augcgcuggg cccuccucgu ccuccucgcc uuccucuccc ccgccuccca gaaguccucc       60

aaccucgagg gccgcaccaa guccgucacc cgccagaccg gcuccuccgc cgagaucacc      120

ugcgaccuca ccgucaccaa caccuucuac auccacuggu accuccacca ggagggcaag      180

gccccccagc gccuccucua cuacgacguc uccaccgccc gcgacguccu cgaguccggc      240

cucucccccg gcaaguacua cacccacacc ccccgccgcu gguccuggau ccuccgccuc      300

cagaaccuca ucgagaacga cuccggcguc uacuacugcg ccaccuggga ccgccagaag      360

cuccucuga                                                              369


<210>  3720
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3720
augagauggg cccugcucgu gcuucuggcu uucuugagcc ccgcauccca gaagucuuca       60

aacuuagagg gcaggaccaa aagugucaca cggcaaacug ggagcuccgc cgaaaucacg      120

ugcgaccuga ccguuacaaa uacuuuuuac auucacuggu aucuacauca ggagggaaag      180

gcgccucagc gccuccugua cuaugaugug ucuaccgcuc gagacguacu ugaaucgggu      240

cugucaccag gcaaauacua uacacacacc ccgcguagau ggagcuggau auugaggcuc      300

cagaaccuga ucgagaauga uaguggggug uacuauugug ccacuuggga ccggcaaaag      360

cugcucuga                                                              369


<210>  3721
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3721
augagauggg cccugcuggu gcugcuggcc uuccugagcc ccgccagcca gaagagcagc       60

aaccuggagg gcagaaccaa gagcgugacc agacagaccg gcagcagcgc cgagaucacc      120

ugcgaccuga ccgugaccaa caccuucuac auccacuggu accugcacca ggagggcaag      180

gccccccaga gacugcugua cuacgacgug agcaccgcca gagacgugcu ggagagcggc      240

cugagccccg gcaaguacua cacccacacc cccagaagau ggagcuggau ccugagacug      300

cagaaccuga ucgagaacga cagcggcgug uacuacugcg ccaccuggga cagacagaag      360

cugcuguga                                                              369


<210>  3722
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TVC_(TRGV3)__Homo_sapiens__M13231.1

<400>  3722
augagauggg cccugcucgu gcugcuugcu uuccugagcc ccgccuccca gaagucuagc       60

aaccucgagg gccggaccaa auccgucaca cgccaaacgg ggucuagcgc ggaaauuacc      120

ugcgaccuga caguuaccaa uacauuuuac auccacuggu aucuucauca ggagggaaag      180

gcuccucaga gacugcucua cuaugaugug uccaccgccc gggacgugcu ggaaucuggc      240

cugagcccgg ggaaauacua uacacacacg ccccgcagau gguccuggau ccuccggcug      300

cagaaccuua uugagaauga uagcggaguc uacuauugug ccaccuggga ccgccaaaag      360

cugcucuga                                                              369


<210>  3723
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TX101__Homo_sapiens__Q9BY14-2

<400>  3723

Met Gly Ala Arg Gln Ile Gln Thr Ser Ser Ser Gln Thr Ser Pro Glu 
1               5                   10                  15      


Glu Ala Met Gly Thr Pro Arg Ile Gln His Leu Leu Ile Leu Leu Val 
            20                  25                  30          


Leu Gly Ala Ser Leu Leu Thr Ser Gly Leu Glu Leu Tyr Cys Gln Lys 
        35                  40                  45              


Gly Leu Ser Met Thr Val Glu Ala Asp Pro Ala Asn Met Phe Asn Trp 
    50                  55                  60                  


Thr Thr Glu Glu Val Glu Thr Cys Asp Lys Gly Ala Leu Cys Gln Glu 
65                  70                  75                  80  


Thr Ile Leu Ile Ile Lys Ala Gly Thr Glu Thr Ala Ile Leu Ala Thr 
                85                  90                  95      


Lys Gly Cys Ile Pro Glu Gly Glu Glu Ala Ile Thr Ile Val Gln His 
            100                 105                 110         


Ser Ser Pro Pro Gly Leu Ile Val Thr Ser Tyr Ser Asn Tyr Cys Glu 
        115                 120                 125             


Asp Ser Phe Cys Asn Asp Lys Asp Ser Leu Ser Gln Phe Trp Glu Phe 
    130                 135                 140                 


Ser Glu Thr Thr Ala Ser Thr Val Ser Thr Thr Leu His Cys Pro Thr 
145                 150                 155                 160 


Cys Val Ala Leu Gly Thr Cys Phe Ser Ala Pro Ser Leu Pro Cys Pro 
                165                 170                 175     


Asn Gly Thr Thr Arg Cys Tyr Gln Gly Lys Leu Glu Ile Thr Gly Gly 
            180                 185                 190         


Gly Ile Glu Ser Ser Val Glu Val Lys Gly Cys Thr Ala Met Ile Gly 
        195                 200                 205             


Cys Arg Leu Met Ser Gly Ile Leu Ala Val Gly Pro Met Phe Val Arg 
    210                 215                 220                 


Glu Ala Cys Pro His Gln Leu Leu Thr Gln Pro Arg Lys Thr Glu Asn 
225                 230                 235                 240 


Gly Ala Thr Cys Leu Pro Ile Pro Val Trp Gly Leu Gln Leu Leu Leu 
                245                 250                 255     


Pro Leu Leu Leu Pro Ser Phe Ile His Phe Ser 
            260                 265         


<210>  3724
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TX101__Homo_sapiens__CCDS12619.1

<400>  3724
augggggcga ggcagaucca gaccagcucc ucccagaccu cuccagaaga agccauggga       60

accccucgua uccagcauuu gcugauccuc cugguccuag gagccucccu ccugaccucg      120

ggccuagagc uguauuguca aaagggucug uccaugacug uggaagcaga uccagccaau      180

auguuuaacu ggaccacaga ggaaguggag acuugugaca aaggggcacu uugccaggaa      240

accauacuaa uaauuaaagc agggacugag acagccauuu uggccacgaa gggcugcauc      300

ccggaagggg aggaggccau aacaauuguc cagcacucuu caccucccgg ccugaucgug      360

accuccuaca guaacuacug ugaggauucc uucuguaaug acaaagacag ccugucucag      420

uuuugggagu ucagugagac cacagcuucc acugugucaa caacccucca uuguccaacc      480

uguguggcuu uggggaccug uuucagugcu ccuucucuuc ccugucccaa ugguacaacu      540

cgaugcuauc aaggaaaacu ugagaucacu ggagguggca uugagucguc uguggagguc      600

aaaggcugua cagccaugau uggcugcagg cugaugucug gaaucuuagc aguaggaccc      660

auguuuguga gggaagcgug cccacaucag cugcucacuc aaccucgaaa gacugaaaau      720

ggggccaccu gucuucccau uccuguuugg ggguuacagc uacugcugcc auugcugcug      780

ccaucauuua uucacuuuuc cuaa                                             804


<210>  3725
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TX101__Homo_sapiens__CCDS12619.1

<400>  3725
augggcgccc gccagaucca gaccagcucc agccagaccu cccccgagga ggccaugggg       60

acgccgcgga uccagcaccu ccugauccug cuggugcucg gcgcgagccu gcugaccucc      120

gggcucgagc uguacugcca gaagggccug agcaugaccg ucgaggccga ccccgccaac      180

auguucaacu ggaccacgga ggagguggag accugcgaca agggggcccu cugccaggag      240

accauccuga ucaucaaggc cggcaccgag acggcgaucc uggccaccaa gggcugcauc      300

cccgaggggg aggaggccau caccaucgug cagcacucca gcccgcccgg ccucaucguc      360

accuccuaca gcaacuacug cgaggacucc uucugcaacg acaaggacag ccugucccag      420

uucugggagu ucagcgagac gaccgccucc accgugagca ccacgcugca cugcccgacc      480

ugcguggcgc ucgggaccug cuucuccgcc cccagccugc ccugccccaa cggcaccacg      540

cgcugcuacc aggggaagcu ggagaucacc ggcggcggga ucgaguccag cgucgaggug      600

aagggcugca ccgccaugau cgggugccgg cucaugagcg gcauccuggc cgugggcccc      660

auguucgucc gcgaggccug cccccaccag cugcucaccc agccccggaa gacggagaac      720

ggggcgaccu gccugccgau ccccgugugg ggccugcagc uccugcugcc ccuccugcug      780

cccuccuuca uccacuucag cuga                                             804


<210>  3726
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TX101__Homo_sapiens__CCDS12619.1

<400>  3726
augggcgccc gccagaucca gaccuccucc ucccagaccu cccccgagga ggccaugggc       60

accccccgca uccagcaccu ccucauccuc cucguccucg gcgccucccu ccucaccucc      120

ggccucgagc ucuacugcca gaagggccuc uccaugaccg ucgaggccga ccccgccaac      180

auguucaacu ggaccaccga ggaggucgag accugcgaca agggcgcccu cugccaggag      240

accauccuca ucaucaaggc cggcaccgag accgccaucc ucgccaccaa gggcugcauc      300

cccgagggcg aggaggccau caccaucguc cagcacuccu ccccccccgg ccucaucguc      360

accuccuacu ccaacuacug cgaggacucc uucugcaacg acaaggacuc ccucucccag      420

uucugggagu ucuccgagac caccgccucc accgucucca ccacccucca cugccccacc      480

ugcgucgccc ucggcaccug cuucuccgcc cccucccucc ccugccccaa cggcaccacc      540

cgcugcuacc agggcaagcu cgagaucacc ggcggcggca ucgaguccuc cgucgagguc      600

aagggcugca ccgccaugau cggcugccgc cucauguccg gcauccucgc cgucggcccc      660

auguucgucc gcgaggccug cccccaccag cuccucaccc agccccgcaa gaccgagaac      720

ggcgccaccu gccuccccau ccccgucugg ggccuccagc uccuccuccc ccuccuccuc      780

cccuccuuca uccacuucuc cuga                                             804


<210>  3727
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TX101__Homo_sapiens__CCDS12619.1

<400>  3727
augggcgcca gacagaucca aaccagcucc ucucagacau caccagagga agcuaugggg       60

acuccuagga uucagcaucu gcucauacuu cugguguugg gagcaaguuu acugacgagc      120

ggucuagagc ucuacugcca gaagggccug uccaugaccg ucgaagccga cccagcgaac      180

auguucaauu ggacaacuga ggaaguugag accugugaua aaggggcucu uugccaagag      240

acaauccuga uuaucaaggc cggaaccgaa acugcaauuu uggccacaaa aggcuguauc      300

ccggagggug aagaggcuau aaccaucgug cagcacucuu cgcccccugg gcucauugua      360

acgucauaua gcaacuacug cgaggacagu uuuuguaaug auaaggacuc ccugucucag      420

uucugggaau uuagcgagac uaccgcaucc acagugucaa cuacccugca cugcccaaca      480

ugugucgccc ucggaaccug cuucagugcu cccagcuuac cuuguccaaa cggcacgacu      540

cggugcuauc agggcaaacu ggaaaucaca gggggaggua uugagucuuc cguggaaguu      600

aagggcugua ccgccaugau cgggugccgc cuuaugucag gaauauuggc ggugggcccc      660

auguuugucc gagaggcaug cccucaucaa cugcuaacuc agccacguaa gacagagaau      720

ggugccaccu gucucccgau ucccgugugg gggcugcagc uucuguugcc ucuccuguua      780

cccagcuuca uccacuuuag uuga                                             804


<210>  3728
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TX101__Homo_sapiens__CCDS12619.1

<400>  3728
augggcgcca gacagaucca gaccagcagc agccagacca gccccgagga ggccaugggc       60

acccccagaa uccagcaccu gcugauccug cuggugcugg gcgccagccu gcugaccagc      120

ggccuggagc uguacugcca gaagggccug agcaugaccg uggaggccga ccccgccaac      180

auguucaacu ggaccaccga ggagguggag accugcgaca agggcgcccu gugccaggag      240

accauccuga ucaucaaggc cggcaccgag accgccaucc uggccaccaa gggcugcauc      300

cccgagggcg aggaggccau caccaucgug cagcacagca gcccccccgg ccugaucgug      360

accagcuaca gcaacuacug cgaggacagc uucugcaacg acaaggacag ccugagccag      420

uucugggagu ucagcgagac caccgccagc accgugagca ccacccugca cugccccacc      480

ugcguggccc ugggcaccug cuucagcgcc cccagccugc ccugccccaa cggcaccacc      540

agaugcuacc agggcaagcu ggagaucacc ggcggcggca ucgagagcag cguggaggug      600

aagggcugca ccgccaugau cggcugcaga cugaugagcg gcauccuggc cgugggcccc      660

auguucguga gagaggccug cccccaccag cugcugaccc agcccagaaa gaccgagaac      720

ggcgccaccu gccugcccau ccccgugugg ggccugcagc ugcugcugcc ccugcugcug      780

cccagcuuca uccacuucag cuga                                             804


<210>  3729
<211>  804
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TX101__Homo_sapiens__CCDS12619.1

<400>  3729
augggcgcca gacagaucca aaccagcucc ucucagacaa gccccgagga agcuaugggg       60

acgccucgga uucagcaucu gcucauccug cuugugcugg gagccucccu ccugaccucu      120

ggccuugagc uguacugcca gaaggggcuc agcaugacag ucgaagcgga cccggcuaac      180

auguucaauu ggaccacaga ggaaguugag accugugaua aaggagcccu gugccaagag      240

acaauucuga ucauuaaggc cggcaccgaa acggcuaucc ucgccaccaa aggguguauc      300

cccgagggag aagaggcuau uacaaucgug cagcacuccu cuccucccgg ccugauugug      360

accagcuauu ccaacuacug cgaggacagc uuuuguaaug auaaggacuc ucuuucccag      420

uucugggaau uuagcgagac aaccgccucu acggucucca caacccugca cugcccuaca      480

uguguggcgc ucggaaccug cuucagcgcc cccucucugc cuuguccgaa cgggaccaca      540

cgcugcuauc agggaaaacu ugaaaucacg ggcgggggaa uugaguccag cguugaagug      600

aagggcugua ccgcuaugau cgggugcaga cugauguccg gcauucucgc cgucggcccc      660

auguuugugc gggaggcuug cccucaucaa cugcugacac agccccgcaa gaccgagaau      720

ggcgccacau gucucccuau ccccguuugg gggcugcagc uucugcuccc gcugcuucug      780

ccuucuuuca uccacuuuag cuga                                             804


<210>  3730
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__A0A024DBG7

<400>  3730

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Arg His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3731
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AHZ44440

<400>  3731
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuagacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3732
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AHZ44440

<400>  3732
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggaggug uaccccgagg ccaacgcccc cauccgccac     1260

aaccgcgaga gcuacauggu ccccuucauc ccgcuguacc ggaacggcga cuucuucauc     1320

uccagcaagg accuggggua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgca ucugguccug gcugcucggc     1440

gccgcgaugg ugggggccgu gcugacggcc cugcucgccg gccuggucag ccugcucugc     1500

cggcacaagc gcaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3733
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AHZ44440

<400>  3733
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc cauccgccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3734
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AHZ44440

<400>  3734
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccaucuu ugagcagugg     1200

cuacgcagac acaggccucu gcaagaggua uaccccgaag cgaaugcccc aauucggcau     1260

aaccgagaga gcuauauggu ucccuucauc ccucucuacc gcaauggcga cuuuuucauc     1320

ucuucaaagg aucuggggua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua uuaaaucuua ccuggaacag gcaucgagaa uauggagcug guugcucgga     1440

gcugccaugg ugggcgcugu ccugaccgcc uuacuggcag gucuaguguc ccuccugugu     1500

aggcacaagc ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3735
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AHZ44440

<400>  3735
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucagacac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3736
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AHZ44440

<400>  3736
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcaucuu ugagcagugg     1200

cuucggagac accgcccccu gcaagaggug uacccugaag ccaaugcccc cauucggcau     1260

aacagagagu cuuauauggu cccguucauc ccucucuacc gcaauggaga cuuuuucauu     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua ucaaauccua ccuggaacag gcuucucgga uuuggagcug gcuccugggc     1440

gcggccaugg ugggggcugu gcugaccgcc cuccuggccg gacuugucuc ccugcucugu     1500

agacacaagc gcaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3737
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__L8B082

<400>  3737

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3738
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39051

<400>  3738
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3739
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39051

<400>  3739
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgaga gcuacauggu ccccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accugggcua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgga ucugguccug gcugcucggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cugcucgccg gccuggucag ccugcucugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3740
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39051

<400>  3740
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3741
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39051

<400>  3741
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccaucuu ugagcagugg     1200

cuacgcagac acaggccucu gcaagaggua uaccccgaag cgaaugcccc aauuggccau     1260

aaccgggaga gcuauauggu ucccuucauc ccucucuacc gaaaugggga cuuuuucauc     1320

ucuucaaagg aucugggaua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua uuaaaucuua ccuggaacag gcaucgcgca uauggagcug guugcucggc     1440

gcugccaugg ugggugcugu ccugaccgcc uuacuggcag ggcuaguguc ccuccugugu     1500

agacacaaga ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3742
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39051

<400>  3742
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3743
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39051

<400>  3743
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcaucuu ugagcagugg     1200

cuucggagac accgcccccu gcaagaggug uacccugaag ccaaugcccc cauuggacau     1260

aaccgggagu cuuauauggu cccguucauc ccucucuaca gaaauggcga cuuuuucauu     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua ucaaauccua ccuggaacag gcuucucgca uuuggagcug gcuccugggg     1440

gcggccaugg ugggagcugu gcugaccgcc cuccuggccg gccuugucuc ccugcucugu     1500

cggcacaaga gaaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3744
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__L8B086

<400>  3744

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Gln Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3745
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39049

<400>  3745
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccaaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3746
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39049

<400>  3746
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcagcggc accgcccgcu ccaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aaccgggaga gcuacauggu ccccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accugggcua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgca ucugguccug gcugcucggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cugcucgccg gccuggucag ccugcucugc     1500

cggcacaagc gcaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3747
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39049

<400>  3747
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccagcgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3748
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39049

<400>  3748
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccaucuu ugagcagugg     1200

cuacaacgcc acagaccucu gcaggaggua uaccccgaag cgaaugcccc aauuggccau     1260

aacagggaga gcuauauggu ucccuucauc ccucucuacc ggaaugggga cuuuuucauc     1320

ucuucaaagg aucugggaua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua uuaaaucuua ccuggaacaa gcaucgcgaa uauggagcug guugcucggc     1440

gcugccaugg ugggugcugu ccugaccgcc uuacuggcag ggcuaguguc ccuccugugu     1500

cgccacaaga gaaagcagcu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3749
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39049

<400>  3749
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugcagagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3750
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39049

<400>  3750
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcaucuu ugagcagugg     1200

cuucaacggc acagaccccu gcaggaggug uacccugaag ccaaugcccc cauuggacau     1260

aaccgcgagu cuuauauggu cccguucauc ccucucuacc ggaauggcga cuuuuucauu     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua ucaaauccua ccuggaacag gcuucuagaa uuuggagcug gcuccugggg     1440

gcggccaugg ugggagcugu gcugaccgcc cuccuggccg gccuugucuc ccugcucugu     1500

cgccacaagc ggaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3751
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__L8B0B9

<400>  3751

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Tyr 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3752
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39050

<400>  3752
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggauaugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3753
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39050

<400>  3753
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuacgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcugu ccccggccag cuucuucucc agcuggcaga ucgugugcag ccggcucgag      840

gaguacaacu cccaccagag ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaaguc ccgcaccccg cggcucccca gcuccgccga cguggaguuc      960

ugccugagcc ugacgcagua cgaguccggc agcauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagagc     1080

uccaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu ccaggggucc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acagcaucuu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

agcuccaagg accugggcua cgacuacagc uaccuccagg acagcgaccc cgacuccuuc     1380

caggacuaca ucaagagcua ccuggagcag gccucccgga ucuggagcug gcugcucggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cugcucgccg gccuggucuc ccugcucugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacagcc ucuaccaguc ccaccuguga                                      1590


<210>  3754
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39050

<400>  3754
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuacgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3755
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39050

<400>  3755
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcuacgaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uauaugggag gccagcaucc uacaaaucca      780

aaccuccuga gucccgcuag cuuuuucucu uccuggcaaa uuguuugcuc acgccuugag      840

gaauacaaua gccaccagag ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc uaggacgccg cggcucccuu ccagcgccga cguggaauuu      960

ugccugucgu uaacucagua ugagucuggc uccauggaua aagcggcaaa cuucucauuu     1020

cguaauaccc uggaaggcuu cgccaguccc cucacaggga ucgcugacgc cagccagucc     1080

ucuaugcaua acgcacuuca cauauacaug aauggaacua ugagccaagu ccaggguuca     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acaguaucuu ugagcagugg     1200

cuacgcagac acaggccucu gcaagaggua uaucccgaag cgaaugcccc aauuggccau     1260

aaccgggagu ccuacauggu ucccuucauc ccucucuauc gaaaugggga cuuuuucauc     1320

agcucuaagg aucugggaua cgauuacuca uaucuucagg acagugaucc agacagcuuc     1380

caggacuaca uuaaauccua ucuggaacag gcaucucgca uauggucgug guugcucggc     1440

gcugccaugg ugggugcugu ccugaccgcc uuacuggcag ggcuagugag ccuccugugu     1500

agacacaaga ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaccauuccc ucuaucaguc acaccuguga                                      1590


<210>  3756
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39050

<400>  3756
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcuacgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3757
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39050

<400>  3757
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcuacgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uauaugggag gccagcaucc gaccaauccu      780

aaccuccuga gccccgccuc cuuuuucucc agcuggcaaa uugugugcuc ccggcuugag      840

gaauacaauu cucaccagag ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaaguc ccggaccccu cgccugccga gcucugcuga cgucgaauuu      960

ugccuuuccc ugacacagua ugagagcggc ucuauggaua aagccgcuaa cuucagcuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cucucagagc     1080

uccaugcaua acgcucugca cauuuacaug aauggcacaa ugagccaagu gcaggggucu     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acuccaucuu ugagcagugg     1200

cuucggagac accgcccccu gcaagaggug uauccugaag ccaaugcccc cauuggacau     1260

aaccgggaga gcuacauggu cccguucauc ccucucuaua gaaauggcga cuuuuucauu     1320

ucuuccaagg aucugggcua cgauuacagc uaucuucagg acuccgaucc cgacucuuuc     1380

caggacuaca ucaaaagcua ucuggaacag gcuucccgca uuuggucuug gcuccugggg     1440

gcggccaugg ugggagcugu gcugaccgcc cuccuggccg gccuugucag ccugcucugu     1500

cggcacaaga gaaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaccauuccc ucuaucagag ccaccuguga                                      1590


<210>  3758
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__O75767

<400>  3758

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Val Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Gly Phe Phe Pro Trp Leu Lys Val Tyr 
        195                 200                 205             


Tyr Tyr Arg Phe Val Ile Gly Leu Arg Val Trp Gln Trp Glu Val Ile 
    210                 215                 220                 


Ser Cys Lys Leu Ile Lys Arg Ala Thr Thr Arg Gln Pro 
225                 230                 235         


<210>  3759
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__CAA04137

<400>  3759
augagccccc uuuggugggg guuucugcuc aguugcuugg gcugcaaaau ccugccagga       60

gcccaggguc aguucccccg agucugcaug acgguggaca gccuagugaa caaggagugc      120

ugcccacgcc ugggugcaga gucggccaau gucuguggcu cucagcaagg ccgggggcag      180

ugcacagagg ugcgagccga cacaaggccc uggagugguc ccuacauccu acgaaaccag      240

gaugaccgug agcuguggcc aagaaaauuc uuccaccgga ccugcaagug cacaggaaac      300

uuugccggcu auaauugugg agacugcaag uuuggcugga ccggucccaa cugcgagcgg      360

aagaaaccac cagugauucg gcagaacauc cauuccuuga guccucagga aagagagcag      420

uucuugggcg ccuuagaucu cgcgaagaag agaguacacc ccgacuacgu gaucaccaca      480

caacacuggg ugggccugcu ugggcccaau ggaacccagc cgcaguuugc caacugcagu      540

guuuaugauu uuuuugugug gcuccauuau uauucuguua gagauacauu auuagguggg      600

uuuuuuccuu ggcugaaggu auauuauuac agguuuguga uuggguugag gguauggcag      660

ugggaaguaa uuucaugcaa guuaauuaag agagcaacca caaggcagcc uuag            714


<210>  3760
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__CAA04137

<400>  3760
augagccccc uguggugggg cuuccuccug uccugccugg ggugcaagau ccucccgggc       60

gcccaggggc aguucccccg cgugugcaug accgucgaca gccuggugaa caaggagugc      120

ugcccccggc ugggcgccga guccgcgaac gugugcggga gccagcaggg ccgcggccag      180

ugcaccgagg uccgggccga cacgcgcccc ugguccgggc cguacauccu ccggaaccag      240

gacgaccgcg agcuguggcc ccggaaguuc uuccaccgga ccugcaagug caccggcaac      300

uucgccgggu acaacugcgg cgacugcaag uucgggugga ccggccccaa cugcgagcgc      360

aagaagcccc cggugauccg ccagaacauc cacagccuga gcccccagga gcgggagcag      420

uuccucggcg cccuggaccu ggccaagaag cgcgugcacc ccgacuacgu caucacgacc      480

cagcacuggg uggggcuccu gggccccaac gggacccagc cgcaguucgc gaacugcucc      540

guguacgacu ucuucgucug gcugcacuac uacuccgugc gggacacccu ccugggcggc      600

uucuuccccu ggcugaaggu guacuacuac cgcuucguca ucgggcuccg gguguggcag      660

ugggagguga ucagcugcaa gcugaucaag cgcgccacga cccggcagcc cuga            714


<210>  3761
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__CAA04137

<400>  3761
augucccccc ucuggugggg cuuccuccuc uccugccucg gcugcaagau ccuccccggc       60

gcccagggcc aguucccccg cgucugcaug accgucgacu cccucgucaa caaggagugc      120

ugcccccgcc ucggcgccga guccgccaac gucugcggcu cccagcaggg ccgcggccag      180

ugcaccgagg uccgcgccga cacccgcccc ugguccggcc ccuacauccu ccgcaaccag      240

gacgaccgcg agcucuggcc ccgcaaguuc uuccaccgca ccugcaagug caccggcaac      300

uucgccggcu acaacugcgg cgacugcaag uucggcugga ccggccccaa cugcgagcgc      360

aagaagcccc ccgucauccg ccagaacauc cacucccucu ccccccagga gcgcgagcag      420

uuccucggcg cccucgaccu cgccaagaag cgcguccacc ccgacuacgu caucaccacc      480

cagcacuggg ucggccuccu cggccccaac ggcacccagc cccaguucgc caacugcucc      540

gucuacgacu ucuucgucug gcuccacuac uacuccgucc gcgacacccu ccucggcggc      600

uucuuccccu ggcucaaggu cuacuacuac cgcuucguca ucggccuccg cgucuggcag      660

ugggagguca ucuccugcaa gcucaucaag cgcgccacca cccgccagcc cuga            714


<210>  3762
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__CAA04137

<400>  3762
augagccccc uguggugggg cuuccuccuu uccugccugg gguguaagau cuugccugga       60

gcccaggguc aauuuccaag agugugcaug accgucgacu cuuuaguuaa caaagagugu      120

ugcccgaggc ugggcgcuga aucagcaaau guguguggga gucagcaggg acggggccag      180

ugcacagagg uacgcgccga uacucgaccc uggagcgguc cuuacauucu acguaaccaa      240

gacgauagag aacucuggcc aaggaaguuc uuucaccgga cguguaaaug caccgggaau      300

uucgcgggau auaacugugg cgacugcaag uuuggcugga cagggcccaa uugugagcgc      360

aaaaagccuc cagugauaag acagaacauc cauucccugu cuccccagga aagggagcag      420

uuccuuggag cucuggauuu ggccaagaaa cggguccacc cugacuacgu gauuacuacc      480

caacauuggg uuggucuccu gggcccaaau gggacacagc cgcaguuugc aaacugcucg      540

guguaugauu ucuuugucug gcugcacuac uauucagugc gcgacacccu cuuaggaggc      600

uucuuucccu ggcugaaggu auacuauuac cgauucguua ucggucuuag aguguggcag      660

ugggagguca uuagcugcaa auugaucaag agggccacua cacggcaacc uuga            714


<210>  3763
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__CAA04137

<400>  3763
augagccccc uguggugggg cuuccugcug agcugccugg gcugcaagau ccugcccggc       60

gcccagggcc aguuccccag agugugcaug accguggaca gccuggugaa caaggagugc      120

ugccccagac ugggcgccga gagcgccaac gugugcggca gccagcaggg cagaggccag      180

ugcaccgagg ugagagccga caccagaccc uggagcggcc ccuacauccu gagaaaccag      240

gacgacagag agcuguggcc cagaaaguuc uuccacagaa ccugcaagug caccggcaac      300

uucgccggcu acaacugcgg cgacugcaag uucggcugga ccggccccaa cugcgagaga      360

aagaagcccc ccgugaucag acagaacauc cacagccuga gcccccagga gagagagcag      420

uuccugggcg cccuggaccu ggccaagaag agagugcacc ccgacuacgu gaucaccacc      480

cagcacuggg ugggccugcu gggccccaac ggcacccagc cccaguucgc caacugcagc      540

guguacgacu ucuucgugug gcugcacuac uacagcguga gagacacccu gcugggcggc      600

uucuuccccu ggcugaaggu guacuacuac agauucguga ucggccugag aguguggcag      660

ugggagguga ucagcugcaa gcugaucaag agagccacca ccagacagcc cuga            714


<210>  3764
<211>  714
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__CAA04137

<400>  3764
augagccccc uguggugggg cuuccuccug uccugccuug gguguaagau ccugccugga       60

gcccagggcc aauuuccgag agugugcaug accgucgacu cucucguuaa caaagagugu      120

ugcccccggc ugggggcuga aagcgccaau guguguggau cccagcaggg ccgcgggcag      180

ugcacagagg ugagagcgga uacgcggccu uggucuggac ccuacauucu ucgcaaccaa      240

gacgauagag aacuguggcc ucggaaguuc uuucaccgca ccuguaaaug cacaggcaau      300

uucgcuggcu auaacugugg ggacugcaag uuuggaugga ccggccccaa uugugagcgg      360

aaaaagccuc cggucaucag acagaacauu cauagccucu cuccccagga acgcgagcag      420

uuccuggggg cccuggaucu cgccaagaaa agagugcacc cugacuacgu uaucacaacc      480

caacauuggg ugggacugcu uggccccaau gggacacagc cucaguuugc uaacugcucc      540

gucuaugauu ucuuugugug gcugcacuac uauagcguuc gggacacccu ccugggaggc      600

uucuuucccu ggcuuaaggu guacuauuac cgcuucguca uuggccugag aguguggcag      660

ugggagguga ucuccugcaa acucaucaag cgggccacga cccgccaacc guga            714


<210>  3765
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__P14679

<400>  3765

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3766
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AAA61242

<400>  3766
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3767
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AAA61242

<400>  3767
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgaga gcuacauggu ccccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accugggcua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgga ucugguccug gcugcucggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cugcucgccg gccuggucag ccugcucugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3768
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AAA61242

<400>  3768
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3769
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AAA61242

<400>  3769
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccaucuu ugagcagugg     1200

cuacgcagac acaggccucu gcaagaggua uaccccgaag cgaaugcccc aauuggccau     1260

aaccgggaga gcuauauggu ucccuucauc ccucucuacc gaaaugggga cuuuuucauc     1320

ucuucaaagg aucugggaua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua uuaaaucuua ccuggaacag gcaucgcgca uauggagcug guugcucggc     1440

gcugccaugg ugggugcugu ccugaccgcc uuacuggcag ggcuaguguc ccuccugugu     1500

agacacaaga ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3770
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AAA61242

<400>  3770
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3771
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AAA61242

<400>  3771
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcaucuu ugagcagugg     1200

cuucggagac accgcccccu gcaagaggug uacccugaag ccaaugcccc cauuggacau     1260

aaccgggagu cuuauauggu cccguucauc ccucucuaca gaaauggcga cuuuuucauu     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua ucaaauccua ccuggaacag gcuucucgca uuuggagcug gcuccugggg     1440

gcggccaugg ugggagcugu gcugaccgcc cuccuggccg gccuugucuc ccugcucugu     1500

cggcacaaga gaaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3772
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__U3M8N0

<400>  3772

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Val Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3773
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39054

<400>  3773
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacgugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3774
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39054

<400>  3774
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacgugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cgucgaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu gcaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgaga gcuacauggu gcccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accugggcua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgga ucugguccug gcugcucggg     1440

gccgcgaugg ugggcgccgu ccugacggcc cugcucgccg gccuggugag ccugcucugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3775
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39054

<400>  3775
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacgucggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3776
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39054

<400>  3776
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacguuggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uugugugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cgucgaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu gcaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucguag acuccaucuu ugagcagugg     1200

cuacgcagac acaggccucu gcaagagguu uaccccgaag cgaaugcccc aauuggccau     1260

aaccgggaga gcuauauggu gcccuucauc ccucucuacc gaaaugggga cuuuuucauc     1320

ucuucaaagg aucugggaua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua uuaaaucuua ccuggaacag gcaucgcgca uauggagcug guugcucggc     1440

gcugccaugg ucggugcugu gcugaccgcc uuacuggcag ggcuaguguc ccuccugugu     1500

agacacaaga ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3777
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39054

<400>  3777
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacgugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3778
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39054

<400>  3778
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacgugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugucugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cguggaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu ucaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucgugg acagcaucuu ugagcagugg     1200

cuucggagac accgcccccu gcaagagguc uacccugaag ccaaugcccc cauuggacau     1260

aaccgggagu cuuauauggu gccguucauc ccucucuaca gaaauggcga cuuuuucauu     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua ucaaauccua ccuggaacag gcuucucgca uuuggagcug gcuccugggg     1440

gcggccaugg ugggagcugu ccugaccgcc cuccuggccg gccuuguuuc ccugcucugu     1500

cggcacaaga gaaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3779
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__U3M9D5

<400>  3779

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Leu Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3780
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39162

<400>  3780
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauuuu ugagcagugg     1200

cuccgaaggc accgucuucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3781
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39162

<400>  3781
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccaucuu cgagcagugg     1200

cugcggcgcc accggcuccu gcaggaggug uacccggagg ccaacgcccc caucggccac     1260

aaccgcgaga gcuacauggu ccccuucauc ccccuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accucggcua cgacuacagc uaccugcagg acuccgaccc ggacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgga ucugguccug gcuccugggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cuccuggccg gccuggucag ccuccugugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagcccc ugcucaugga gaaggaggac     1560

uaccacuccc uguaccagag ccaccuguga                                      1590


<210>  3782
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39162

<400>  3782
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccaucuu cgagcagugg     1200

cuccgccgcc accgccuccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3783
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39162

<400>  3783
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccaucuu ugagcagugg     1200

cuacgcagac acaggcugcu ccaagaggua uacccugaag cgaaugcccc cauuggccau     1260

aaccgggaga gcuauauggu uccauucauc ccccuguacc gaaaugggga cuuuuucauc     1320

ucuucaaagg aucuuggaua ugauuacagu uaccugcagg acagcgaucc ugacuccuuc     1380

caggacuaua uuaaaucuua cuuggaacag gcaucgcgca uauggagcug gcuccugggc     1440

gcugccaugg ugggugcugu cuuaaccgcc cugcuagcag ggcucguguc ccugcuuugu     1500

agacacaaga ggaagcaauu gccagaggaa aaacagccgc ugcucaugga gaaggaggau     1560

uaucauucac uguaccagag ucaccuuuga                                      1590


<210>  3784
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39162

<400>  3784
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcaucuu cgagcagugg     1200

cugagaagac acagacugcu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3785
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39162

<400>  3785
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcaucuu ugagcagugg     1200

cuucggagac accgccugcu ccaagaggug uaccccgaag ccaaugcccc uauuggacau     1260

aaccgggagu cuuauauggu ccccuucauc ccgcuguaca gaaauggcga cuuuuucauu     1320

uccagcaagg aucuuggcua ugauuacucc uaccugcagg acucugaucc ugacagcuuc     1380

caggacuaua ucaaauccua ccucgaacag gcuucucgca uuuggagcug gcugcugggg     1440

gcggccaugg ugggagcugu gcucaccgcc cugcuugccg gccuggucuc ccuccugugu     1500

cggcacaaga gaaagcaacu gcccgaggaa aaacagccuc uucucaugga gaaggaggau     1560

uaucauagcc uguaccaguc ucaccuguga                                      1590


<210>  3786
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__U3M9J2

<400>  3786

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Met Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  3787
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  tyrosinase__Homo_sapiens__AGV39086

<400>  3787
augcuccugg cuguuuugua cugccugcug uggaguuucc agaccuccgc uggccauuuc       60

ccuagagccu gugucuccuc uaagaaccug auggagaagg aaugcugucc accguggagc      120

ggggacagga gucccugugg ccagcuuuca ggcagagguu ccugucagaa uauccuucug      180

uccaaugcac cacuugggcc ucaauuuccc uucacagggg uggaugaccg ggagucgugg      240

ccuuccgucu uuuauaauag gaccugccag ugcucuggca acuucauggg auucaacugu      300

ggaaacugca aguuuggcuu uuggggacca aacugcacag agagacgacu cuuggugaga      360

agaaacaucu ucgauuugag ugccccagag aaggacaaau uuuuugccua ccucacuuua      420

gcaaagcaua ccaucagcuc agacuauguc auccccauag ggaccuaugg ccaaaugaaa      480

aauggaucaa cacccauguu uaacgacauc aauauuuaug accucuuugu cuggaugcau      540

uauuaugugu caauggaugc acugcuuggg ggaucugaaa ucuggagaga cauugauuuu      600

gcccaugaag caccagcuuu ucugccuugg cauagacucu ucuuguugcg gugggaacaa      660

gaaauccaga agcugacagg agaugaaaac uucacuauuc cauauuggga cuggcgggau      720

gcagaaaagu gugacauuug cacagaugag uacaugggag gucagcaccc cacaaauccu      780

aacuuacuca gcccagcauc auucuucucc ucuuggcaga uugucuguag ccgauuggag      840

gaguacaaca gccaucaguc uuuaugcaau ggaacgcccg agggaccuuu acggcguaau      900

ccuggaaacc augacaaauc cagaacccca aggcuccccu cuucagcuga uguagaauuu      960

ugccugaguu ugacccaaua ugaaucuggu uccauggaua aagcugccaa uuucagcuuu     1020

agaaauacac uggaaggauu ugcuagucca cuuacuggga uagcggaugc cucucaaagc     1080

agcaugcaca augccuugca caucuauaug aauggaacaa ugucccaggu acagggaucu     1140

gccaacgauc cuaucuuccu ucuucaccau gcauuuguug acaguauguu ugagcagugg     1200

cuccgaaggc accguccucu ucaagaaguu uauccagaag ccaaugcacc cauuggacau     1260

aaccgggaau ccuacauggu uccuuuuaua ccacuguaca gaaaugguga uuucuuuauu     1320

ucauccaaag aucugggcua ugacuauagc uaucuacaag auucagaccc agacucuuuu     1380

caagacuaca uuaaguccua uuuggaacaa gcgagucgga ucuggucaug gcuccuuggg     1440

gcggcgaugg uaggggccgu ccucacugcc cugcuggcag ggcuugugag cuugcugugu     1500

cgucacaaga gaaagcagcu uccugaagaa aagcagccac uccucaugga gaaagaggau     1560

uaccacagcu uguaucagag ccauuuauaa                                      1590


<210>  3788
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       tyrosinase__Homo_sapiens__AGV39086

<400>  3788
augcugcucg ccgugcugua cugccugcuc uggagcuucc agaccuccgc cggccacuuc       60

ccccgcgcgu gcgucagcuc caagaaccug auggagaagg agugcugccc gcccuggagc      120

ggggaccggu cccccugcgg ccagcugagc gggcgcggcu ccugccagaa cauccuccug      180

agcaacgcgc cccuggggcc gcaguucccc uucaccggcg uggacgaccg ggaguccugg      240

cccagcgugu ucuacaaccg cacgugccag ugcuccggca acuucauggg guucaacugc      300

ggcaacugca aguucggguu cuggggcccc aacugcaccg agcggcgccu ccugguccgg      360

cgcaacaucu ucgaccugag cgccccggag aaggacaagu ucuucgccua ccucacccug      420

gccaagcaca ccaucuccag cgacuacgug auccccaucg ggacguacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguca gcauggacgc ccuccucggg ggcuccgaga ucuggcggga caucgacuuc      600

gcccacgagg cccccgccuu ccugccgugg caccgccugu uccugcugcg gugggagcag      660

gagauccaga agcucaccgg ggacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gcggagaagu gcgacaucug cacggacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gcccggccuc cuucuucagc agcuggcaga ucgugugcuc ccggcucgag      840

gaguacaaca gccaccaguc ccugugcaac gggacccccg agggcccccu gcgccggaac      900

cccgggaacc acgacaagag ccgcaccccg cggcuccccu ccagcgccga cguggaguuc      960

ugccuguccc ugacgcagua cgagagcggc uccauggaca aggccgccaa cuucagcuuc     1020

cgcaacaccc ucgagggguu cgcgagcccc cugaccggca ucgccgacgc cucccagucc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugucccaggu ccaggggagc     1140

gccaacgacc ccaucuuccu ccugcaccac gcguucgugg acuccauguu cgagcagugg     1200

cugcggcgcc accggccgcu ccaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgaga gcuacauggu ccccuucauc ccgcuguacc gcaacgggga cuucuucauc     1320

uccagcaagg accugggcua cgacuacagc uaccuccagg acuccgaccc cgacagcuuc     1380

caggacuaca ucaaguccua ccuggagcag gccagccgga ucugguccug gcugcucggg     1440

gccgcgaugg ugggcgccgu gcugacggcc cugcucgccg gccuggucag ccugcucugc     1500

cgccacaagc ggaagcagcu gcccgaggag aagcagccgc ugcugaugga gaaggaggac     1560

uaccacuccc ucuaccagag ccaccuguga                                      1590


<210>  3789
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       tyrosinase__Homo_sapiens__AGV39086

<400>  3789
augcuccucg ccguccucua cugccuccuc ugguccuucc agaccuccgc cggccacuuc       60

ccccgcgccu gcgucuccuc caagaaccuc auggagaagg agugcugccc ccccuggucc      120

ggcgaccgcu cccccugcgg ccagcucucc ggccgcggcu ccugccagaa cauccuccuc      180

uccaacgccc cccucggccc ccaguucccc uucaccggcg ucgacgaccg cgaguccugg      240

cccuccgucu ucuacaaccg caccugccag ugcuccggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agcgccgccu ccucguccgc      360

cgcaacaucu ucgaccucuc cgcccccgag aaggacaagu ucuucgccua ccucacccuc      420

gccaagcaca ccaucuccuc cgacuacguc auccccaucg gcaccuacgg ccagaugaag      480

aacggcucca cccccauguu caacgacauc aacaucuacg accucuucgu cuggaugcac      540

uacuacgucu ccauggacgc ccuccucggc ggcuccgaga ucuggcgcga caucgacuuc      600

gcccacgagg cccccgccuu ccuccccugg caccgccucu uccuccuccg cugggagcag      660

gagauccaga agcucaccgg cgacgagaac uucaccaucc ccuacuggga cuggcgcgac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccuccucu cccccgccuc cuucuucucc uccuggcaga ucgucugcuc ccgccucgag      840

gaguacaacu cccaccaguc ccucugcaac ggcacccccg agggcccccu ccgccgcaac      900

cccggcaacc acgacaaguc ccgcaccccc cgccuccccu ccuccgccga cgucgaguuc      960

ugccucuccc ucacccagua cgaguccggc uccauggaca aggccgccaa cuucuccuuc     1020

cgcaacaccc ucgagggcuu cgccuccccc cucaccggca ucgccgacgc cucccagucc     1080

uccaugcaca acgcccucca caucuacaug aacggcacca ugucccaggu ccagggcucc     1140

gccaacgacc ccaucuuccu ccuccaccac gccuucgucg acuccauguu cgagcagugg     1200

cuccgccgcc accgcccccu ccaggagguc uaccccgagg ccaacgcccc caucggccac     1260

aaccgcgagu ccuacauggu ccccuucauc ccccucuacc gcaacggcga cuucuucauc     1320

uccuccaagg accucggcua cgacuacucc uaccuccagg acuccgaccc cgacuccuuc     1380

caggacuaca ucaaguccua ccucgagcag gccucccgca ucugguccug gcuccucggc     1440

gccgccaugg ucggcgccgu ccucaccgcc cuccucgccg gccucgucuc ccuccucugc     1500

cgccacaagc gcaagcagcu ccccgaggag aagcagcccc uccucaugga gaaggaggac     1560

uaccacuccc ucuaccaguc ccaccucuga                                      1590


<210>  3790
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       tyrosinase__Homo_sapiens__AGV39086

<400>  3790
augcugcucg ccgugcuuua cugccuguug uggagcuucc agaccuccgc uggccacuuu       60

cccagagcau gugucucuuc aaagaacuua auggagaaag aaugcugucc uccauggagu      120

ggggacagga gcccgugcgg acaacugucc ggucggggcu cuugucagaa uauccuacuc      180

ucgaacgccc ccuuggggcc ucaguuccca uuuacaggag uugaugaccg cgagucaugg      240

cccagcgugu ucuauaaucg aacuugccag uguaguggca acuuuauggg uuucaauugc      300

gggaacugua aguuuggauu cuggggcccu aauugcacgg aacguagacu ucugguaagg      360

cggaacauuu uugauuuguc cgcgccagag aaagacaagu ucuuugcuua ccucacccug      420

gccaaacaua caauaucuag cgauuaugug auccccauug gcacuuacgg gcaaaugaag      480

aauggaucca ccccuauguu caacgacauc aauauuuaug aucuguuugu cuggaugcac      540

uacuaugugu caauggacgc acucuuaggu ggcagugaaa ucuggcgcga uauagacuuc      600

gcccaugagg cuccagcauu ccugccgugg cacagacuuu uucugcugag gugggagcag      660

gaaauccaga agcuaacagg ggaugagaac uucaccauuc ccuacuggga cuggcgggau      720

gccgaaaaau gugacaucug cacugacgag uacaugggag gccagcaucc uacaaaucca      780

aaccuccuga gccccgcuuc cuuuuucucu ucauggcaaa uuguuugcag ccgccuugag      840

gaauauaaua gucaccaguc ucuguguaac gguaccccug aggggccauu gcgaagaaac      900

cccggaaauc acgauaaguc caggacgccg cggcucccua gcucggccga cguggaauuu      960

ugccugucuu uaacucagua cgaguccggc ucaauggaua aagcggcaaa cuucaguuuu     1020

cguaauaccc uggaaggcuu cgccagcccc cucacaggga ucgcugacgc cucccagucu     1080

agcaugcaua acgcacuuca cauauauaug aauggaacua ugucacaagu ccaggguagu     1140

gcuaacgauc caauuuuucu guugcaucac gccuucgugg acuccauguu ugagcagugg     1200

cuacgcagac acaggccucu gcaagaggua uaccccgaag cgaaugcccc aaucggccau     1260

aaccgggaga gcuauauggu ucccuucauu ccucucuacc gaaaugggga cuuuuucauc     1320

ucuucaaagg aucugggaua ugauuacagu uaccuucagg acagcgaucc agacuccuuc     1380

caggacuaua ucaaaucuua ccuggaacag gcaucgcgca uuuggagcug guugcucggc     1440

gcugccaugg ugggugcugu ccugaccgcc uuacuggcag ggcuaguguc ccuccugugu     1500

agacacaaga ggaagcaacu uccggaggaa aaacagcccu ugcugaugga gaaggaggau     1560

uaucauucac ucuaccagag ucaccuguga                                      1590


<210>  3791
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       tyrosinase__Homo_sapiens__AGV39086

<400>  3791
augcugcugg ccgugcugua cugccugcug uggagcuucc agaccagcgc cggccacuuc       60

cccagagccu gcgugagcag caagaaccug auggagaagg agugcugccc ccccuggagc      120

ggcgacagaa gccccugcgg ccagcugagc ggcagaggca gcugccagaa cauccugcug      180

agcaacgccc cccugggccc ccaguucccc uucaccggcg uggacgacag agagagcugg      240

cccagcgugu ucuacaacag aaccugccag ugcagcggca acuucauggg cuucaacugc      300

ggcaacugca aguucggcuu cuggggcccc aacugcaccg agagaagacu gcuggugaga      360

agaaacaucu ucgaccugag cgcccccgag aaggacaagu ucuucgccua ccugacccug      420

gccaagcaca ccaucagcag cgacuacgug auccccaucg gcaccuacgg ccagaugaag      480

aacggcagca cccccauguu caacgacauc aacaucuacg accuguucgu guggaugcac      540

uacuacguga gcauggacgc ccugcugggc ggcagcgaga ucuggagaga caucgacuuc      600

gcccacgagg cccccgccuu ccugcccugg cacagacugu uccugcugag augggagcag      660

gagauccaga agcugaccgg cgacgagaac uucaccaucc ccuacuggga cuggagagac      720

gccgagaagu gcgacaucug caccgacgag uacaugggcg gccagcaccc caccaacccc      780

aaccugcuga gccccgccag cuucuucagc agcuggcaga ucgugugcag cagacuggag      840

gaguacaaca gccaccagag ccugugcaac ggcacccccg agggcccccu gagaagaaac      900

cccggcaacc acgacaagag cagaaccccc agacugccca gcagcgccga cguggaguuc      960

ugccugagcc ugacccagua cgagagcggc agcauggaca aggccgccaa cuucagcuuc     1020

agaaacaccc uggagggcuu cgccagcccc cugaccggca ucgccgacgc cagccagagc     1080

agcaugcaca acgcccugca caucuacaug aacggcacca ugagccaggu gcagggcagc     1140

gccaacgacc ccaucuuccu gcugcaccac gccuucgugg acagcauguu cgagcagugg     1200

cugagaagac acagaccccu gcaggaggug uaccccgagg ccaacgcccc caucggccac     1260

aacagagaga gcuacauggu gcccuucauc ccccuguaca gaaacggcga cuucuucauc     1320

agcagcaagg accugggcua cgacuacagc uaccugcagg acagcgaccc cgacagcuuc     1380

caggacuaca ucaagagcua ccuggagcag gccagcagaa ucuggagcug gcugcugggc     1440

gccgccaugg ugggcgccgu gcugaccgcc cugcuggccg gccuggugag ccugcugugc     1500

agacacaaga gaaagcagcu gcccgaggag aagcagcccc ugcugaugga gaaggaggac     1560

uaccacagcc uguaccagag ccaccuguga                                      1590


<210>  3792
<211>  1590
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       tyrosinase__Homo_sapiens__AGV39086

<400>  3792
augcugcucg ccgugcugua cugccuucug uggagcuucc agaccuccgc uggccacuuu       60

cccagagccu gugucucuag caagaaccuc auggagaaag aaugcugucc uccguggucc      120

ggggaccggu cucccugcgg acaacugagc ggccgcgggu ccugucagaa uauccuucug      180

ucuaacgcgc cucucggacc ccaguucccu uuuacaggcg uugaugacag agagagcugg      240

cccuccgugu ucuauaaucg gacgugccag uguagcggga acuuuauggg auucaauugc      300

ggcaacugua aguuuggcuu cugggggccu aauugcaccg aacgcagacu gcuggugcgg      360

cgcaacauuu uugaucucuc ugcuccggag aaagacaagu ucuuugccua ccugacacuu      420

gccaaacaua ccaucuccag cgauuauguc auucccaucg gaacauacgg ccaaaugaag      480

aaugggucua ccccuauguu caacgacauu aauaucuaug aucuguuugu guggaugcac      540

uacuauguuu ccauggacgc ucuccuggga ggcagcgaaa ucuggagaga uauugacuuc      600

gcccaugagg cucccgccuu ccuuccuugg caccggcugu uucuccugcg cugggagcag      660

gaaauccaga agcugacagg ggaugagaac uucaccauuc ccuacuggga cuggagagau      720

gcggaaaaau gugacaucug cacggacgag uacaugggag gccagcaucc gaccaauccu      780

aaccuccugu cucccgccuc cuuuuucagc uccuggcaaa uugugugcuc ucggcuugag      840

gaauauaaua gccaccaguc ccuguguaac ggcacaccug aggggccccu ccgcagaaac      900

cccggaaauc acgauaagag ccggaccccu cgccugccgu cuuccgcuga cgucgaauuu      960

ugccuuagcc ugacacagua cgagucuggc agcauggaua aagccgcuaa cuucuccuuu     1020

agaaauaccc ucgaaggguu cgccucuccc cugacgggaa ucgcggacgc cagccagucc     1080

agcaugcaua acgcucugca cauuuauaug aauggcacaa ugucucaagu gcaggggucc     1140

gccaacgauc cuaucuuucu ccugcaucac gcuuucguug acagcauguu ugagcagugg     1200

cuucggagac accgcccccu gcaagaggug uacccugaag ccaaugcccc caucggacau     1260

aaccgggagu cuuauauggu cccguucauu ccucucuaca gaaauggcga cuuuuucauc     1320

uccagcaagg aucugggcua ugauuacucc uaccuucagg acucugaucc cgacagcuuc     1380

caggacuaua uuaaauccua ccuggaacag gcuucucgca ucuggagcug gcuccugggg     1440

gcggccaugg ugggagcugu gcugaccgcc cuccuggccg gccuugucuc ccugcucugu     1500

cggcacaaga gaaagcaacu gccugaggaa aaacagcccc ugcuuaugga gaaggaggau     1560

uaucauagcc ucuaccaguc ucaccuguga                                      1590


<210>  3793
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TYRP1__Homo_sapiens__P17643

<400>  3793

Met Ser Ala Pro Lys Leu Leu Ser Leu Gly Cys Ile Phe Phe Pro Leu 
1               5                   10                  15      


Leu Leu Phe Gln Gln Ala Arg Ala Gln Phe Pro Arg Gln Cys Ala Thr 
            20                  25                  30          


Val Glu Ala Leu Arg Ser Gly Met Cys Cys Pro Asp Leu Ser Pro Val 
        35                  40                  45              


Ser Gly Pro Gly Thr Asp Arg Cys Gly Ser Ser Ser Gly Arg Gly Arg 
    50                  55                  60                  


Cys Glu Ala Val Thr Ala Asp Ser Arg Pro His Ser Pro Gln Tyr Pro 
65                  70                  75                  80  


His Asp Gly Arg Asp Asp Arg Glu Val Trp Pro Leu Arg Phe Phe Asn 
                85                  90                  95      


Arg Thr Cys His Cys Asn Gly Asn Phe Ser Gly His Asn Cys Gly Thr 
            100                 105                 110         


Cys Arg Pro Gly Trp Arg Gly Ala Ala Cys Asp Gln Arg Val Leu Ile 
        115                 120                 125             


Val Arg Arg Asn Leu Leu Asp Leu Ser Lys Glu Glu Lys Asn His Phe 
    130                 135                 140                 


Val Arg Ala Leu Asp Met Ala Lys Arg Thr Thr His Pro Leu Phe Val 
145                 150                 155                 160 


Ile Ala Thr Arg Arg Ser Glu Glu Ile Leu Gly Pro Asp Gly Asn Thr 
                165                 170                 175     


Pro Gln Phe Glu Asn Ile Ser Ile Tyr Asn Tyr Phe Val Trp Thr His 
            180                 185                 190         


Tyr Tyr Ser Val Lys Lys Thr Phe Leu Gly Val Gly Gln Glu Ser Phe 
        195                 200                 205             


Gly Glu Val Asp Phe Ser His Glu Gly Pro Ala Phe Leu Thr Trp His 
    210                 215                 220                 


Arg Tyr His Leu Leu Arg Leu Glu Lys Asp Met Gln Glu Met Leu Gln 
225                 230                 235                 240 


Glu Pro Ser Phe Ser Leu Pro Tyr Trp Asn Phe Ala Thr Gly Lys Asn 
                245                 250                 255     


Val Cys Asp Ile Cys Thr Asp Asp Leu Met Gly Ser Arg Ser Asn Phe 
            260                 265                 270         


Asp Ser Thr Leu Ile Ser Pro Asn Ser Val Phe Ser Gln Trp Arg Val 
        275                 280                 285             


Val Cys Asp Ser Leu Glu Asp Tyr Asp Thr Leu Gly Thr Leu Cys Asn 
    290                 295                 300                 


Ser Thr Glu Asp Gly Pro Ile Arg Arg Asn Pro Ala Gly Asn Val Ala 
305                 310                 315                 320 


Arg Pro Met Val Gln Arg Leu Pro Glu Pro Gln Asp Val Ala Gln Cys 
                325                 330                 335     


Leu Glu Val Gly Leu Phe Asp Thr Pro Pro Phe Tyr Ser Asn Ser Thr 
            340                 345                 350         


Asn Ser Phe Arg Asn Thr Val Glu Gly Tyr Ser Asp Pro Thr Gly Lys 
        355                 360                 365             


Tyr Asp Pro Ala Val Arg Ser Leu His Asn Leu Ala His Leu Phe Leu 
    370                 375                 380                 


Asn Gly Thr Gly Gly Gln Thr His Leu Ser Pro Asn Asp Pro Ile Phe 
385                 390                 395                 400 


Val Leu Leu His Thr Phe Thr Asp Ala Val Phe Asp Glu Trp Leu Arg 
                405                 410                 415     


Arg Tyr Asn Ala Asp Ile Ser Thr Phe Pro Leu Glu Asn Ala Pro Ile 
            420                 425                 430         


Gly His Asn Arg Gln Tyr Asn Met Val Pro Phe Trp Pro Pro Val Thr 
        435                 440                 445             


Asn Thr Glu Met Phe Val Thr Ala Pro Asp Asn Leu Gly Tyr Thr Tyr 
    450                 455                 460                 


Glu Ile Gln Trp Pro Ser Arg Glu Phe Ser Val Pro Glu Ile Ile Ala 
465                 470                 475                 480 


Ile Ala Val Val Gly Ala Leu Leu Leu Val Ala Leu Ile Phe Gly Thr 
                485                 490                 495     


Ala Ser Tyr Leu Ile Arg Ala Arg Arg Ser Met Asp Glu Ala Asn Gln 
            500                 505                 510         


Pro Leu Leu Thr Asp Gln Tyr Gln Cys Tyr Ala Glu Glu Tyr Glu Lys 
        515                 520                 525             


Leu Gln Asn Pro Asn Gln Ser Val Val 
    530                 535         


<210>  3794
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TYRP1__Homo_sapiens__AAC15468

<400>  3794
augagugcuc cuaaacuccu cucucugggc uguaucuucu uccccuugcu acuuuuucag       60

caggcccggg cucaauuccc aagacagugu gccacuguug aggcuuugag aagugguaug      120

uguugcccag accugucccc ugugucuggg ccugggacag accgcugugg cucaucauca      180

gggaggggca gaugugaggc agugacugca gacucccggc cccacagccc ucaguauccc      240

caugauggca gagaugaucg ggaggucugg cccuugcgcu ucuucaauag gacaugucac      300

ugcaacggca auuucucagg acacaacugu gggacgugcc guccuggcug gagaggagcu      360

gccugugacc agaggguucu cauagucagg agaaaucuuc uggacuuaag uaaagaagaa      420

aagaaccacu uuguccgggc ccuggauaug gcaaagcgca caacucaccc uuuauuuguc      480

auugccacca ggagaucaga agaaauacug gggccagaug gcaacacgcc acaauuugag      540

aacauuucca uuuauaacua cuuuguuugg acacacuauu acucagucaa aaagacuuuc      600

cuugggguag gacaggaaag cuuuggugaa guggauuucu cucaugaggg accagcuuuu      660

cucacauggc acagguacca ccuccugcgu cuggagaaag acaugcagga aauguugcaa      720

gagccuucuu ucucccuucc uuacuggaau uuugcaacgg ggaaaaaugu cugugauauc      780

ugcacggaug acuugauggg auccagaagc aacuuugauu ccacucuaau aagcccaaac      840

ucugucuuuu cucaauggcg aguggucugu gacuccuugg aagauuauga uacccuggga      900

acacuuugua acagcaccga ggaugggcca auuaggagaa auccagcugg aaauguggcc      960

agaccaaugg ugcaacgucu uccugaacca caggaugucg cucagugcuu ggaaguuggu     1020

uuauuugaca cgccuccuuu uuauuccaac ucuacaaaca guuuccgaaa cacaguggaa     1080

gguuacagug accccacggg aaaguaugac ccugcuguuc gaagucuuca caauuuggcu     1140

caucuauucc ugaauggaac agggggacaa acccauuugu cuccaaauga uccuauuuuu     1200

guccuccugc acaccuucac agaugcaguc uuugaugaau ggcugaggag auacaaugcu     1260

gauauaucca cauuuccauu ggaaaaugcc ccuauuggac auaauagaca auacaacaug     1320

gugccauucu ggcccccagu caccaacaca gaaauguuug uuacugcucc agacaaccug     1380

ggauacacuu augaaauuca auggccaagu cgggaguuua guguaccuga gauaauugcc     1440

auagcaguag uuggcgcuuu guuacugguu gcacucauuu uugggacugc uucuuaucug     1500

auucgugcca gacgcaguau ggaugaagcu aaccagccuc uccucacuga ucaguaucaa     1560

ugcuaugcug aagaauauga aaaacuccag aauccuaauc agucuguggu cuaa           1614


<210>  3795
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TYRP1__Homo_sapiens__AAC15468

<400>  3795
augagcgccc ccaagcugcu cucccugggc ugcaucuucu ucccgcugcu ccuguuccag       60

caggcccgcg cgcaguuccc ccggcagugc gccaccgugg aggcccugcg cagcgggaug      120

ugcugccccg accucucccc cgucagcggc ccggggaccg accggugcgg cuccagcucc      180

gggcgcggcc ggugcgaggc cgugacggcc gacagccgcc cccacagccc ccaguacccc      240

cacgacggcc gggacgaccg cgaggugugg ccgcugcggu ucuucaaccg gaccugccac      300

ugcaacggga acuucuccgg ccacaacugc gggaccugcc gccccggcug gcgcggggcg      360

gccugcgacc agcggguccu gaucgugcgc cggaaccucc uggaccuguc caaggaggag      420

aagaaccacu ucgugcgcgc ccucgacaug gccaagcgga ccacgcaccc ccuguucguc      480

aucgcgaccc gccggagcga ggagauccug ggccccgacg gcaacacccc gcaguucgag      540

aacaucucca ucuacaacua cuucgugugg acccacuacu acagcgugaa gaagacguuc      600

cucggggucg gccaggaguc cuucggggag guggacuuca gccacgaggg ccccgccuuc      660

cugaccuggc accgcuacca ccuccugcgg cuggagaagg acaugcagga gaugcugcag      720

gagcccuccu ucagccuccc cuacuggaac uucgccaccg gcaagaacgu gugcgacauc      780

ugcaccgacg accugauggg gucccgcagc aacuucgaca gcacgcugau cuccccgaac      840

agcgucuucu cccaguggcg cguggugugc gacagccucg aggacuacga cacccugggc      900

acccugugca acuccaccga ggacgggccc auccggcgca accccgccgg caacgucgcc      960

cggcccaugg ugcagcgccu cccggagccc caggacgugg cgcagugccu ggaggucggg     1020

cuguucgaca cgccgcccuu cuacagcaac uccaccaaca gcuuccggaa caccguggag     1080

ggcuacuccg accccaccgg caaguacgac cccgccgugc gcagccucca caaccuggcc     1140

caccuguucc ucaacgggac gggcgggcag acccaccugu cccccaacga ccccaucuuc     1200

guccugcucc acaccuucac cgacgccgug uucgacgagu ggcugcggcg cuacaacgcc     1260

gacaucagca cguucccgcu ggagaacgcg cccaucggcc acaaccggca guacaacaug     1320

gugcccuucu ggccgcccgu caccaacacc gagauguucg ugaccgcccc cgacaaccuc     1380

ggguacacgu acgagaucca guggcccucc cgcgaguuca gcgucccgga gaucaucgcc     1440

aucgccgugg ugggcgcccu gcugcucguc gcgcugaucu ucggcaccgc cuccuaccug     1500

auccgggccc gccggagcau ggacgaggcc aaccagcccc uccugaccga ccaguaccag     1560

ugcuacgccg aggaguacga gaagcugcag aaccccaacc aguccguggu guga           1614


<210>  3796
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TYRP1__Homo_sapiens__AAC15468

<400>  3796
auguccgccc ccaagcuccu cucccucggc ugcaucuucu ucccccuccu ccucuuccag       60

caggcccgcg cccaguuccc ccgccagugc gccaccgucg aggcccuccg cuccggcaug      120

ugcugccccg accucucccc cgucuccggc cccggcaccg accgcugcgg cuccuccucc      180

ggccgcggcc gcugcgaggc cgucaccgcc gacucccgcc cccacucccc ccaguacccc      240

cacgacggcc gcgacgaccg cgaggucugg ccccuccgcu ucuucaaccg caccugccac      300

ugcaacggca acuucuccgg ccacaacugc ggcaccugcc gccccggcug gcgcggcgcc      360

gccugcgacc agcgcguccu caucguccgc cgcaaccucc ucgaccucuc caaggaggag      420

aagaaccacu ucguccgcgc ccucgacaug gccaagcgca ccacccaccc ccucuucguc      480

aucgccaccc gccgcuccga ggagauccuc ggccccgacg gcaacacccc ccaguucgag      540

aacaucucca ucuacaacua cuucgucugg acccacuacu acuccgucaa gaagaccuuc      600

cucggcgucg gccaggaguc cuucggcgag gucgacuucu cccacgaggg ccccgccuuc      660

cucaccuggc accgcuacca ccuccuccgc cucgagaagg acaugcagga gaugcuccag      720

gagcccuccu ucucccuccc cuacuggaac uucgccaccg gcaagaacgu cugcgacauc      780

ugcaccgacg accucauggg cucccgcucc aacuucgacu ccacccucau cucccccaac      840

uccgucuucu cccaguggcg cgucgucugc gacucccucg aggacuacga cacccucggc      900

acccucugca acuccaccga ggacggcccc auccgccgca accccgccgg caacgucgcc      960

cgccccaugg uccagcgccu ccccgagccc caggacgucg cccagugccu cgaggucggc     1020

cucuucgaca ccccccccuu cuacuccaac uccaccaacu ccuuccgcaa caccgucgag     1080

ggcuacuccg accccaccgg caaguacgac cccgccgucc gcucccucca caaccucgcc     1140

caccucuucc ucaacggcac cggcggccag acccaccucu cccccaacga ccccaucuuc     1200

guccuccucc acaccuucac cgacgccguc uucgacgagu ggcuccgccg cuacaacgcc     1260

gacaucucca ccuucccccu cgagaacgcc cccaucggcc acaaccgcca guacaacaug     1320

guccccuucu ggccccccgu caccaacacc gagauguucg ucaccgcccc cgacaaccuc     1380

ggcuacaccu acgagaucca guggcccucc cgcgaguucu ccguccccga gaucaucgcc     1440

aucgccgucg ucggcgcccu ccuccucguc gcccucaucu ucggcaccgc cuccuaccuc     1500

auccgcgccc gccgcuccau ggacgaggcc aaccagcccc uccucaccga ccaguaccag     1560

ugcuacgccg aggaguacga gaagcuccag aaccccaacc aguccgucgu cuga           1614


<210>  3797
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TYRP1__Homo_sapiens__AAC15468

<400>  3797
augagcgccc ccaagcugcu cucccuuggc ugcaucuucu uuccucuguu guuauuccag       60

caagcuagag cacaguuucc aaggcagugu gccaccgugg aggcgcugcg gucugggaug      120

ugcuguccgg accuaucacc cgucagugga ccugguacag aucgcugcgg cagcuccucu      180

gggcgaggac guugugaagc uguuacugcc gacucgagac cacacucacc ccaguacccu      240

caugauggca gggacgaucg ggaggugugg ccacuccgcu ucuuuaacag aacgugccac      300

uguaauggua acuucagcgg gcauaauugc ggaaccugua ggcccggcug gcggggcgca      360

gccugcgacc aacgcguacu gauugugcga agaaaccuuc uggauuugag uaaagaagag      420

aagaaucacu uugucagggc ucucgacaug gcaaaacgga caacucaucc ucuguucgug      480

auagccaccc gucgcuccga agagauccug gggccagaug gaaacacacc gcaguuugag      540

aauauuucua ucuauaacua cuucguuugg acccacuauu acagcgugaa gaaaacuuuu      600

cucggugucg gccaggaauc cuucggggag guggacuuuu cacacgaagg acccgcuuuc      660

uuaacauggc auagauauca ucugcuuagg uuggagaagg auaugcagga gaugcugcaa      720

gaaccuaguu ucagccuacc auacuggaau uuugccaccg gcaagaacgu augugacauu      780

ugcacggaug accucauggg uucucggucc aauuucgacu caacucugau cagccccaac      840

aguguguuuu cucaguggcg aguugucugc gauucccuug aggacuauga uacccugggg      900

acauugugua auagcacuga agacggaccu auacgcagaa acccagcggg caauguggca      960

aggcccaugg ugcagcggcu cccggagccu caggaugucg cccaaugccu ggaaguuggc     1020

uuauucgaca cacccccauu uuacucgaac ucuaccaacu ccuuccgcaa uaccguggag     1080

ggguacucag auccuacggg aaaauaugac cccgcuguaa gaagucugca caaccucgcc     1140

caccuuuuuc ugaaugguac uggcgggcag acacacuuga gcccaaacga ucccaucuuc     1200

gugcuacugc auaccuuuac ugacgcaguc uucgaugagu ggcucaggcg uuacaaugcu     1260

gacauuucca cauuuccucu ggaaaacgcc ccaaucggac acaaucggca guauaacaug     1320

gugccguucu ggcccccugu uaccaauacg gagauguuug ugaccgcgcc agacaaccuu     1380

ggcuacacau augaaauuca auggcccucu cgagaguuca gcgucccuga aaucauagcc     1440

auugcagugg uaggugcucu guugcucguu gcccugaucu ucgggacugc uucauacuua     1500

auuagagcca ggcgcaguau ggaugaggca aaucagccac ugcuaaccga ccaguaucag     1560

uguuacgccg aggaauacga gaagcuccaa aaccccaauc aguccguggu cuga           1614


<210>  3798
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TYRP1__Homo_sapiens__AAC15468

<400>  3798
augagcgccc ccaagcugcu gagccugggc ugcaucuucu ucccccugcu gcuguuccag       60

caggccagag cccaguuccc cagacagugc gccaccgugg aggcccugag aagcggcaug      120

ugcugccccg accugagccc cgugagcggc cccggcaccg acagaugcgg cagcagcagc      180

ggcagaggca gaugcgaggc cgugaccgcc gacagcagac cccacagccc ccaguacccc      240

cacgacggca gagacgacag agaggugugg ccccugagau ucuucaacag aaccugccac      300

ugcaacggca acuucagcgg ccacaacugc ggcaccugca gacccggcug gagaggcgcc      360

gccugcgacc agagagugcu gaucgugaga agaaaccugc uggaccugag caaggaggag      420

aagaaccacu ucgugagagc ccuggacaug gccaagagaa ccacccaccc ccuguucgug      480

aucgccacca gaagaagcga ggagauccug ggccccgacg gcaacacccc ccaguucgag      540

aacaucagca ucuacaacua cuucgugugg acccacuacu acagcgugaa gaagaccuuc      600

cugggcgugg gccaggagag cuucggcgag guggacuuca gccacgaggg ccccgccuuc      660

cugaccuggc acagauacca ccugcugaga cuggagaagg acaugcagga gaugcugcag      720

gagcccagcu ucagccugcc cuacuggaac uucgccaccg gcaagaacgu gugcgacauc      780

ugcaccgacg accugauggg cagcagaagc aacuucgaca gcacccugau cagccccaac      840

agcguguuca gccaguggag aguggugugc gacagccugg aggacuacga cacccugggc      900

acccugugca acagcaccga ggacggcccc aucagaagaa accccgccgg caacguggcc      960

agacccaugg ugcagagacu gcccgagccc caggacgugg cccagugccu ggaggugggc     1020

cuguucgaca ccccccccuu cuacagcaac agcaccaaca gcuucagaaa caccguggag     1080

ggcuacagcg accccaccgg caaguacgac cccgccguga gaagccugca caaccuggcc     1140

caccuguucc ugaacggcac cggcggccag acccaccuga gccccaacga ccccaucuuc     1200

gugcugcugc acaccuucac cgacgccgug uucgacgagu ggcugagaag auacaacgcc     1260

gacaucagca ccuucccccu ggagaacgcc cccaucggcc acaacagaca guacaacaug     1320

gugcccuucu ggccccccgu gaccaacacc gagauguucg ugaccgcccc cgacaaccug     1380

ggcuacaccu acgagaucca guggcccagc agagaguuca gcgugcccga gaucaucgcc     1440

aucgccgugg ugggcgcccu gcugcuggug gcccugaucu ucggcaccgc cagcuaccug     1500

aucagagcca gaagaagcau ggacgaggcc aaccagcccc ugcugaccga ccaguaccag     1560

ugcuacgccg aggaguacga gaagcugcag aaccccaacc agagcguggu guga           1614


<210>  3799
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TYRP1__Homo_sapiens__AAC15468

<400>  3799
augagcgccc ccaagcugcu cucccugggc ugcaucuucu uuccucuucu ccuguuccag       60

caagcuagag cccaguuucc gcggcagugu gcgaccgugg aggcucugcg cucugggaug      120

ugcugucccg accuuagccc ugucuccgga cccggcacag auagaugcgg gucuagcucc      180

ggacggggcc gcugugaagc cguuacggcc gacucuagac cucacagccc ccaguacccu      240

caugaugggc gggacgaucg cgaggugugg ccgcugagau ucuuuaaccg gaccugccac      300

uguaauggaa acuucuccgg ccauaauugc ggcacauguc gccccgggug gagaggagcu      360

gccugcgacc aacgggugcu cauuguccgc agaaaccugc uggaucucag caaagaagag      420

aagaaucacu uugugcgggc ucuggacaug gccaaacgca ccacacaucc ucuuuucguu      480

aucgcgacca gacggucuga agagauucug ggccccgaug ggaacacacc ucaguuugag      540

aauaucucca uuuauaacua cuucgugugg acccacuauu acagcgucaa gaaaacguuu      600

cucggagugg gccaggaauc uuucggggag guugacuuuu cccacgaagg acccgccuuc      660

cugaccuggc auagauauca ccuucugcgc cucgagaagg auaugcagga gaugcugcaa      720

gaaccgagcu ucucucugcc uuacuggaau uuugcuacag gcaagaacgu gugugacauc      780

ugcaccgaug accucauggg cucccggagc aauuucgacu ccacacugau cucucccaac      840

agcgucuuuu cccaguggag aguggugugc gauagccuug aggacuauga uacccugggg      900

acgcucugua auucuacaga agacggaccu auucgccgga accccgccgg caaugucgcu      960

agacccaugg uucagcgccu gccugagccg caggaugugg cccaaugccu ugaagugggg     1020

cuguucgaca cacccccuuu uuacuccaac agcaccaacu cuuuccggaa uaccgucgag     1080

ggauacagcg aucccaccgg caaauaugac ccugcgguga gaucccucca uaaccuggcc     1140

caccuguuuc ucaaugggac aggaggccag acgcaccugu cucccaacga uccgaucuuc     1200

guucuucugc auaccuuuac agacgcugug uucgaugagu ggcuccgccg guacaaugcc     1260

gacauuagca ccuuuccucu ggaaaacgcu cccaucggcc acaauagaca guauaacaug     1320

gucccuuucu ggcccccugu gacaaauacc gagauguuug uuacggcccc cgacaaccuu     1380

ggguacacau augaaauuca auggccgucc cgcgaguuca gcgugccuga aaucauugcc     1440

aucgcugucg ugggagcgcu gcuccugguc gcccugaucu ucggcaccgc uucuuaccuc     1500

auucgggcca gacgguccau ggaugaggcc aaucagcccc ugcuuaccga ccaguaucag     1560

uguuacgcug aggaauacga gaagcugcaa aaccccaauc agagcguggu uuga           1614


<210>  3800
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TYRP2__Homo_sapiens__P40126

<400>  3800

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Leu His Ser Phe Thr Asp 
385                 390                 395                 400 


Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp Ala 
                405                 410                 415     


Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn Met 
            420                 425                 430         


Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr Ser 
        435                 440                 445             


Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val Glu 
    450                 455                 460                 


Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr Leu 
465                 470                 475                 480 


Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr Arg 
                485                 490                 495     


Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser Ser 
            500                 505                 510         


Lys Arg Tyr Thr Glu Glu Ala 
        515                 


<210>  3801
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TYRP2__Homo_sapiens__AAA20870

<400>  3801
augagccccc uuuggugggg guuucugcuc aguugcuugg gcugcaaaau ccugccagga       60

gcccaggguc aguucccccg agucugcaug acgguggaca gccuagugaa caaggagugc      120

ugcccacgcc ugggugcaga gucggccaau gucuguggcu cucagcaagg ccgggggcag      180

ugcacagagg ugcgagccga cacaaggccc uggagugguc ccuacauccu acgaaaccag      240

gaugaccgug agcuguggcc aagaaaauuc uuccaccgga ccugcaagug cacaggaaac      300

uuugccggcu auaauugugg agacugcaag uuuggcugga ccggucccaa cugcgagcgg      360

aagaaaccac cagugauucg gcagaacauc cauuccuuga guccucagga aagagagcag      420

uucuugggcg ccuuagaucu cgcgaagaag agaguacacc ccgacuacgu gaucaccaca      480

caacacuggc ugggccugcu ugggcccaau ggaacccagc cgcaguuugc caacugcagu      540

guuuaugauu uuuuugugug gcuccauuau uauucuguua gagauacauu auuaggacca      600

ggacgccccu acagggccau agauuucuca caucaaggac cugcauuugu uaccuggcac      660

cgguaccauu uguugugucu ggaaagagau cuccagcgac ucauuggcaa ugagucuuuu      720

gcuuugcccu acuggaacuu ugccacuggg aggaacgagu gugaugugug uacagaccag      780

cuguuugggg cagcgagacc agacgauccg acucugauua gucggaacuc aagauucucc      840

agcugggaaa cugucuguga uagcuuggau gacuacaacc accuggucac cuugugcaau      900

ggaaccuaug aagguuugcu gagaagaaau caaaugggaa gaaacagcau gaaauugcca      960

accuuaaaag acauacgaga uugccugucu cuccagaagu uugacaaucc ucccuucuuc     1020

cagaacucua ccuucaguuu caggaaugcu uuggaagggu uugauaaagc agaugggacu     1080

cuggauucuc aagugaugag ccuucauaau uugguucauu ccuuccugaa cgggacaaac     1140

gcuuugccac auucagccgc caaugauccc auuuuugugg uucuucauuc cuuuacugau     1200

gccaucuuug augaguggau gaaaagauuu aauccuccug cagaugccug gccucaggag     1260

cuggccccua uuggucacaa ucggauguac aacaugguuc cuuucuuccc uccagugacu     1320

aaugaagaac ucuuuuuaac cucagaccaa cuuggcuaca gcuaugccau cgaucugcca     1380

guuucaguug aagaaacucc agguuggccc acaacucucu uaguagucau gggaacacug     1440

guggcuuugg uuggucuuuu ugugcuguug gcuuuucuuc aauauagaag acuucgaaaa     1500

ggauauacac cccuaaugga gacacauuua agcagcaaga gauacacaga agaagccuag     1560


<210>  3802
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TYRP2__Homo_sapiens__AAA20870

<400>  3802
augagccccc uguggugggg cuuccuccug uccugccugg ggugcaagau ccucccgggc       60

gcccaggggc aguucccccg cgugugcaug accgucgaca gccuggugaa caaggagugc      120

ugcccccggc ugggcgccga guccgcgaac gugugcggga gccagcaggg ccgcggccag      180

ugcaccgagg uccgggccga cacgcgcccc ugguccgggc cguacauccu ccggaaccag      240

gacgaccgcg agcuguggcc ccggaaguuc uuccaccgga ccugcaagug caccggcaac      300

uucgccgggu acaacugcgg cgacugcaag uucgggugga ccggccccaa cugcgagcgc      360

aagaagcccc cggugauccg ccagaacauc cacagccuga gcccccagga gcgggagcag      420

uuccucggcg cccuggaccu ggccaagaag cgcgugcacc ccgacuacgu caucacgacc      480

cagcacuggc ucgggcugcu gggccccaac gggacccagc cgcaguucgc gaacugcucc      540

guguacgacu ucuucgugug gcuccacuac uacuccgucc gggacacccu gcugggcccc      600

ggccgccccu accgggccau cgacuucagc caccaggggc ccgccuucgu gacguggcac      660

cgcuaccacc uccugugccu ggagcgggac cuccagcgcc ugaucggcaa cgaguccuuc      720

gcccugccgu acuggaacuu cgcgaccggg cggaacgagu gcgacgugug caccgaccag      780

cuguucggcg ccgcccgccc cgacgacccc acccucauca gccggaacuc ccgcuucagc      840

uccugggaga cggucugcga cagccuggac gacuacaacc accucgugac ccugugcaac      900

gggaccuacg agggccugcu ccgccggaac cagaugggcc gcaacuccau gaagcugccc      960

acccugaagg acauccggga cugccucagc cugcagaagu ucgacaaccc gcccuucuuc     1020

cagaacucca cguucagcuu ccgcaacgcc cuggaggggu ucgacaaggc cgacggcacc     1080

cucgacagcc aggugauguc ccugcacaac cugguccaca gcuuccucaa cgggaccaac     1140

gcgcugcccc acuccgccgc caacgacccc aucuucgugg ugcugcacag cuucaccgac     1200

gccaucuucg acgaguggau gaagcgguuc aacccgcccg ccgacgcgug gccccaggag     1260

cucgccccca ucggccacaa ccgcauguac aacauggucc cguucuuccc gcccgugacg     1320

aacgaggagc uguuccugac cuccgaccag cucggguaca gcuacgccau cgaccugccc     1380

guguccgucg aggagacccc cggcuggccc accacgcugc ucguggugau gggcacccug     1440

gucgcccugg uggggcuguu cguccuccug gccuuccugc aguaccggcg ccuccggaag     1500

ggcuacacgc cccugaugga gacccaccug agcuccaagc gcuacaccga ggaggcguga     1560


<210>  3803
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TYRP2__Homo_sapiens__AAA20870

<400>  3803
augucccccc ucuggugggg cuuccuccuc uccugccucg gcugcaagau ccuccccggc       60

gcccagggcc aguucccccg cgucugcaug accgucgacu cccucgucaa caaggagugc      120

ugcccccgcc ucggcgccga guccgccaac gucugcggcu cccagcaggg ccgcggccag      180

ugcaccgagg uccgcgccga cacccgcccc ugguccggcc ccuacauccu ccgcaaccag      240

gacgaccgcg agcucuggcc ccgcaaguuc uuccaccgca ccugcaagug caccggcaac      300

uucgccggcu acaacugcgg cgacugcaag uucggcugga ccggccccaa cugcgagcgc      360

aagaagcccc ccgucauccg ccagaacauc cacucccucu ccccccagga gcgcgagcag      420

uuccucggcg cccucgaccu cgccaagaag cgcguccacc ccgacuacgu caucaccacc      480

cagcacuggc ucggccuccu cggccccaac ggcacccagc cccaguucgc caacugcucc      540

gucuacgacu ucuucgucug gcuccacuac uacuccgucc gcgacacccu ccucggcccc      600

ggccgccccu accgcgccau cgacuucucc caccagggcc ccgccuucgu caccuggcac      660

cgcuaccacc uccucugccu cgagcgcgac cuccagcgcc ucaucggcaa cgaguccuuc      720

gcccuccccu acuggaacuu cgccaccggc cgcaacgagu gcgacgucug caccgaccag      780

cucuucggcg ccgcccgccc cgacgacccc acccucaucu cccgcaacuc ccgcuucucc      840

uccugggaga ccgucugcga cucccucgac gacuacaacc accucgucac ccucugcaac      900

ggcaccuacg agggccuccu ccgccgcaac cagaugggcc gcaacuccau gaagcucccc      960

acccucaagg acauccgcga cugccucucc cuccagaagu ucgacaaccc ccccuucuuc     1020

cagaacucca ccuucuccuu ccgcaacgcc cucgagggcu ucgacaaggc cgacggcacc     1080

cucgacuccc aggucauguc ccuccacaac cucguccacu ccuuccucaa cggcaccaac     1140

gcccuccccc acuccgccgc caacgacccc aucuucgucg uccuccacuc cuucaccgac     1200

gccaucuucg acgaguggau gaagcgcuuc aacccccccg ccgacgccug gccccaggag     1260

cucgccccca ucggccacaa ccgcauguac aacauggucc ccuucuuccc ccccgucacc     1320

aacgaggagc ucuuccucac cuccgaccag cucggcuacu ccuacgccau cgaccucccc     1380

gucuccgucg aggagacccc cggcuggccc accacccucc ucgucgucau gggcacccuc     1440

gucgcccucg ucggccucuu cguccuccuc gccuuccucc aguaccgccg ccuccgcaag     1500

ggcuacaccc cccucaugga gacccaccuc uccuccaagc gcuacaccga ggaggccuga     1560


<210>  3804
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TYRP2__Homo_sapiens__AAA20870

<400>  3804
augagccccc uguggugggg cuuccuccuu uccugccugg gguguaagau cuugccugga       60

gcccaggguc aauuuccaag agugugcaug accgucgacu cuuuaguuaa caaagagugu      120

ugcccgaggc ugggcgcuga aucagcaaau guguguggga gucagcaggg acggggccag      180

ugcacagagg uacgcgccga uacucgaccc uggagcgguc cuuacauucu acguaaccaa      240

gacgauagag aacucuggcc aaggaaguuc uuucaccgga cguguaaaug caccgggaau      300

uucgcgggau auaacugugg cgacugcaag uuuggcugga cagggcccaa uugugagcgc      360

aaaaagccuc cagugauaag acagaacauc cauucccugu cuccccagga aagggagcag      420

uuccuuggag cucuggauuu ggccaagaaa cggguccacc cugacuacgu gauuacuacc      480

caacauuggc ucggucugcu gggcccaaau gggacacagc cgcaguuugc aaacugcucg      540

guuuaugauu ucuuugugug gcuccacuac uauucagucc gcgacaccuu acugggaccc      600

ggccgaccuu acagagccau cgauuucagc caucaggguc cagcuuuugu gacuuggcac      660

agguaucacc uuuugugccu ggagcgggac cuacaacguc ucauugggaa ugaaaguuuc      720

gcacugcccu acuggaacuu ugccacagga cgcaaugagu gugauguaug caccgaccag      780

cuuuucggcg cugccagacc ugaugaccca acgcugaucu ccaggaacuc ucgguucagc      840

uccugggaaa cuguuuguga cucauuggau gacuacaauc aucucgugac ccugugcaac      900

ggcacauaug agggguuacu gcgacgcaau cagaugggaa gaaacaguau gaagcucccc      960

acucuuaaag auauaaggga cugucugagc uugcaaaagu uugauaaccc gccuuucuuu     1020

caaaauucua ccuucuccuu ucggaacgcg cuagaggguu ucgacaaagc agauggcaca     1080

cuggacucac aggucaugag ccuccacaau cuggugcaua guuuucuuaa cgggaccaau     1140

gcccugcccc acucugcugc caacgaucca aucuucgugg ucuugcacuc cuuuacggac     1200

gcaauuuucg augaauggau gaagcgcuuu aauccucccg cugacgccug gccacaggag     1260

cucgcgccca ucggacauaa cagaauguac aauaugguuc cuuucuuucc accggugacu     1320

aacgaggaac uguucuuaac aagcgaccag cugggcuauu cguacgccau ugaucuaccc     1380

guaucugugg aagagacccc ugguuggcca acuacacucc uggucgugau ggggacccuu     1440

guugcauugg ugggccuguu cguccuccug gcuuuucuuc aguauaggcg ucugcggaag     1500

ggauacacgc ccuugaugga gacccaccuc uccucaaaac gauauacaga agaggccuga     1560


<210>  3805
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TYRP2__Homo_sapiens__AAA20870

<400>  3805
augagccccc uguggugggg cuuccugcug agcugccugg gcugcaagau ccugcccggc       60

gcccagggcc aguuccccag agugugcaug accguggaca gccuggugaa caaggagugc      120

ugccccagac ugggcgccga gagcgccaac gugugcggca gccagcaggg cagaggccag      180

ugcaccgagg ugagagccga caccagaccc uggagcggcc ccuacauccu gagaaaccag      240

gacgacagag agcuguggcc cagaaaguuc uuccacagaa ccugcaagug caccggcaac      300

uucgccggcu acaacugcgg cgacugcaag uucggcugga ccggccccaa cugcgagaga      360

aagaagcccc ccgugaucag acagaacauc cacagccuga gcccccagga gagagagcag      420

uuccugggcg cccuggaccu ggccaagaag agagugcacc ccgacuacgu gaucaccacc      480

cagcacuggc ugggccugcu gggccccaac ggcacccagc cccaguucgc caacugcagc      540

guguacgacu ucuucgugug gcugcacuac uacagcguga gagacacccu gcugggcccc      600

ggcagacccu acagagccau cgacuucagc caccagggcc ccgccuucgu gaccuggcac      660

agauaccacc ugcugugccu ggagagagac cugcagagac ugaucggcaa cgagagcuuc      720

gcccugcccu acuggaacuu cgccaccggc agaaacgagu gcgacgugug caccgaccag      780

cuguucggcg ccgccagacc cgacgacccc acccugauca gcagaaacag cagauucagc      840

agcugggaga ccgugugcga cagccuggac gacuacaacc accuggugac ccugugcaac      900

ggcaccuacg agggccugcu gagaagaaac cagaugggca gaaacagcau gaagcugccc      960

acccugaagg acaucagaga cugccugagc cugcagaagu ucgacaaccc ccccuucuuc     1020

cagaacagca ccuucagcuu cagaaacgcc cuggagggcu ucgacaaggc cgacggcacc     1080

cuggacagcc aggugaugag ccugcacaac cuggugcaca gcuuccugaa cggcaccaac     1140

gcccugcccc acagcgccgc caacgacccc aucuucgugg ugcugcacag cuucaccgac     1200

gccaucuucg acgaguggau gaagagauuc aacccccccg ccgacgccug gccccaggag     1260

cuggccccca ucggccacaa cagaauguac aacauggugc ccuucuuccc ccccgugacc     1320

aacgaggagc uguuccugac cagcgaccag cugggcuaca gcuacgccau cgaccugccc     1380

gugagcgugg aggagacccc cggcuggccc accacccugc ugguggugau gggcacccug     1440

guggcccugg ugggccuguu cgugcugcug gccuuccugc aguacagaag acugagaaag     1500

ggcuacaccc cccugaugga gacccaccug agcagcaaga gauacaccga ggaggccuga     1560


<210>  3806
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TYRP2__Homo_sapiens__AAA20870

<400>  3806
augagccccc uguggugggg cuuccuccug uccugccuug gguguaagau ccugccugga       60

gcccagggcc aauuuccgag agugugcaug accgucgacu cucucguuaa caaagagugu      120

ugcccccggc ugggggcuga aagcgccaau guguguggau cccagcaggg ccgcgggcag      180

ugcacagagg ugagagcgga uacgcggccu uggucuggac ccuacauucu ucgcaaccaa      240

gacgauagag aacuguggcc ucggaaguuc uuucaccgca ccuguaaaug cacaggcaau      300

uucgcuggcu auaacugugg ggacugcaag uuuggaugga ccggccccaa uugugagcgg      360

aaaaagccuc cggucaucag acagaacauu cauagccuca gcccccagga acgcgagcag      420

uuccuggggg cccuggaucu cgccaagaaa agagugcacc cugacuacgu uaucacaacc      480

caacauuggc ugggacuucu gggccccaau gggacacagc cucaguuugc uaacugcucu      540

guguaugauu ucuuugucug gcuccacuac uauagcgugc gggacacccu gcuuggaccc      600

ggccgcccgu acagagccau ugauuucucc caucagggcc cugcuuuugu uacguggcac      660

cgguaucauc ugcucugccu ggagcgcgac cugcaaagac ucaucgggaa ugaauccuuc      720

gcccugcccu acuggaacuu ugcgaccgga cggaaugagu gugaugugug cacagaccag      780

cuuuucggcg ccgcuagacc ugaugacccc acccugaucu cucgcaacuc ccgguucagc      840

ucuugggaaa cagucuguga cucccucgau gacuacaauc accuggugac ccuuugcaac      900

gggacguaug agggacugcu cagacgcaau cagaugggcc ggaacagcau gaagcugccc      960

acacugaaag auauuagaga cugucucucu cugcaaaagu uugauaaccc uccguucuuu     1020

caaaauucca ccuucagcuu ucgcaacgcc cuugaggggu ucgacaaagc ugauggaaca     1080

cuggacuccc aggugauguc ucuccacaau cugguccaua gcuuucuuaa cggcaccaau     1140

gcccugcccc acuccgcggc caacgauccu aucuucguug ugcuccacag cuuuaccgac     1200

gcuauuuucg augaauggau gaagcgguuu aaucccccug ccgacgcuug gccccaggag     1260

cuggccccga ucggccauaa cagaauguac aauauggugc cuuucuuucc cccugucaca     1320

aacgaggaac uguuccucac gucugaccag cugggguauu ccuacgccau ugaucuuccc     1380

gugagcguug aagagacccc uggauggccc acaacccugc ucguggucau gggcacacug     1440

guggcucugg uugggcuuuu cgugcuccug gcguuucugc aguaucgccg gcucagaaag     1500

ggauacaccc cgcugaugga gacgcaccuu ucuagcaaac gcuauacaga agaggccuga     1560


<210>  3807
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  UPA__Homo_sapiens__Q96NZ9

<400>  3807

Met Arg Arg Leu Leu Leu Val Thr Ser Leu Val Val Val Leu Leu Trp 
1               5                   10                  15      


Glu Ala Gly Ala Val Pro Ala Pro Lys Val Pro Ile Lys Met Gln Val 
            20                  25                  30          


Lys His Trp Pro Ser Glu Gln Asp Pro Glu Lys Ala Trp Gly Ala Arg 
        35                  40                  45              


Val Val Glu Pro Pro Glu Lys Asp Asp Gln Leu Val Val Leu Phe Pro 
    50                  55                  60                  


Val Gln Lys Pro Lys Leu Leu Thr Thr Glu Glu Lys Pro Arg Gly Gln 
65                  70                  75                  80  


Gly Arg Gly Pro Ile Leu Pro Gly Thr Lys Ala Trp Met Glu Thr Glu 
                85                  90                  95      


Asp Thr Leu Gly His Val Leu Ser Pro Glu Pro Asp His Asp Ser Leu 
            100                 105                 110         


Tyr His Pro Pro Pro Glu Glu Asp Gln Gly Glu Glu Arg Pro Arg Leu 
        115                 120                 125             


Trp Val Met Pro Asn His Gln Val Leu Leu Gly Pro Glu Glu Asp Gln 
    130                 135                 140                 


Asp His Ile Tyr His Pro Gln 
145                 150     


<210>  3808
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  UPA__Homo_sapiens__CCDS7679.1

<400>  3808
augaggaggc uccuccuggu caccagccug gugguugugc ugcuguggga ggcaggugca       60

gucccagcac ccaagguccc uaucaagaug caagucaaac acuggcccuc agagcaggac      120

ccagagaagg ccuggggcgc ccguguggug gagccuccgg agaaggacga ccagcuggug      180

gugcuguucc cuguccagaa gccgaaacuc uugaccaccg aggagaagcc acgaggucag      240

ggcaggggcc ccauccuucc aggcaccaag gccuggaugg agaccgagga cacccugggc      300

cauguccuga gucccgagcc cgaccaugac agccuguacc acccuccgcc ugaggaggac      360

cagggcgagg agaggccccg guugugggug augccaaauc accaggugcu ccugggaccg      420

gaggaagacc aagaccacau cuaccacccc caguag                                456


<210>  3809
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       UPA__Homo_sapiens__CCDS7679.1

<400>  3809
augcgccggc ugcuccuggu gaccagccug gucguggugc uccuguggga ggccggcgcc       60

guccccgcgc ccaaggugcc caucaagaug caggucaagc acuggcccuc cgagcaggac      120

cccgagaagg ccuggggcgc ccgcguggug gagccgcccg agaaggacga ccagcuggug      180

guccucuucc ccgugcagaa gcccaagcug cugaccacgg aggagaagcc gcgggggcag      240

gggcgcggcc ccauccuccc cgggaccaag gccuggaugg agaccgagga cacccugggc      300

cacgugcuga gccccgagcc ggaccacgac ucccucuacc acccgccgcc cgaggaggac      360

cagggcgagg agcggccccg ccuguggguc augcccaacc accaggugcu gcucgggccc      420

gaggaggacc aggaccacau cuaccacccc caguga                                456


<210>  3810
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       UPA__Homo_sapiens__CCDS7679.1

<400>  3810
augcgccgcc uccuccucgu caccucccuc gucgucgucc uccucuggga ggccggcgcc       60

guccccgccc ccaagguccc caucaagaug caggucaagc acuggcccuc cgagcaggac      120

cccgagaagg ccuggggcgc ccgcgucguc gagccccccg agaaggacga ccagcucguc      180

guccucuucc ccguccagaa gcccaagcuc cucaccaccg aggagaagcc ccgcggccag      240

ggccgcggcc ccauccuccc cggcaccaag gccuggaugg agaccgagga cacccucggc      300

cacguccucu cccccgagcc cgaccacgac ucccucuacc accccccccc cgaggaggac      360

cagggcgagg agcgcccccg ccucuggguc augcccaacc accagguccu ccucggcccc      420

gaggaggacc aggaccacau cuaccacccc caguga                                456


<210>  3811
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       UPA__Homo_sapiens__CCDS7679.1

<400>  3811
augagaaggc ugcuccuugu gaccagccug gucguugugu uguuauggga ggccggcgcu       60

guacccgcac cuaaagugcc aaucaaaaug caggucaagc acuggccguc cgaacaagac      120

cccgagaaag ccuggggagc gcgggugguu gaaccuccag agaaggauga ccagcuggug      180

guccuauucc ccgugcagaa accuaagcuc cugacaacug aagagaagcc acgcgggcag      240

ggucgaggcc ccauucuucc ugggacgaag gcuuggaugg agaccgaaga uacacuggga      300

cauguauugu cuccagagcc ggaccacgau ucacucuacc aucccccucc agaagaggac      360

caaggcgagg aacgucccag acuguggguu augccuaacc accaggugcu gcucggucca      420

gaggaagauc aggaccauau auaucacccc caguga                                456


<210>  3812
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       UPA__Homo_sapiens__CCDS7679.1

<400>  3812
augagaagac ugcugcuggu gaccagccug gugguggugc ugcuguggga ggccggcgcc       60

gugcccgccc ccaaggugcc caucaagaug caggugaagc acuggcccag cgagcaggac      120

cccgagaagg ccuggggcgc cagaguggug gagccccccg agaaggacga ccagcuggug      180

gugcuguucc ccgugcagaa gcccaagcug cugaccaccg aggagaagcc cagaggccag      240

ggcagaggcc ccauccugcc cggcaccaag gccuggaugg agaccgagga cacccugggc      300

cacgugcuga gccccgagcc cgaccacgac agccuguacc accccccccc cgaggaggac      360

cagggcgagg agagacccag acugugggug augcccaacc accaggugcu gcugggcccc      420

gaggaggacc aggaccacau cuaccacccc caguga                                456


<210>  3813
<211>  456
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       UPA__Homo_sapiens__CCDS7679.1

<400>  3813
augagacggc ugcuccuggu gaccagccuu gucguugugc ugcucuggga ggccggcgcu       60

gugcccgccc cuaagguccc gaucaaaaug caagugaagc acuggcccuc cgaacaggac      120

ccugagaaag cguggggagc ucgcguugug gaacccccug agaaggauga ccagcugguc      180

gugcuuuucc ccguucagaa accuaagcug cucacaacgg aagagaagcc gagagggcag      240

ggccgggggc ccauucugcc uggaaccaaa gccuggaugg agacagaaga uacccugggc      300

caugugcucu cucccgagcc ugaccacgau agccuguacc aucccccgcc ugaagaggac      360

caaggggagg aacgccccag acuuuggguc augccuaacc accaggugcu gcucggaccc      420

gaggaagauc aggaccauau cuaucacccc caguga                                456


<210>  3814
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VEGFR1__Homo_sapiens__B5A924

<400>  3814

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Lys Lys Ala 
                165                 170                 


<210>  3815
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  VEGFR1__Homo_sapiens__ACF47598

<400>  3815
auggucagcu acugggacac cgggguccug cugugcgcgc ugcucagcug ucugcuucuc       60

acaggaucua guucagguuc aaaauuaaaa gauccugaac ugaguuuaaa aggcacccag      120

cacaucaugc aagcaggcca gacacugcau cuccaaugca ggggggaagc agcccauaaa      180

uggucuuugc cugaaauggu gaguaaggaa agcgaaaggc ugagcauaac uaaaucugcc      240

uguggaagaa auggcaaaca auucugcagu acuuuaaccu ugaacacagc ucaagcaaac      300

cacacuggcu ucuacagcug caaauaucua gcuguaccua cuucaaagaa gaaggaaaca      360

gaaucugcaa ucuauauauu uauuagugau acagguagac cuuucguaga gauguacagu      420

gaaauccccg aaauuauaca caugacugaa ggaagggagc ucgucauucc cugccggguu      480

acgucaccua acaucacugu uacuuuaaaa aagaaaaagg cauaa                      525


<210>  3816
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       VEGFR1__Homo_sapiens__ACF47598

<400>  3816
auggugagcu acugggacac cggcguccug cucugcgccc ugcuguccug ccuccugcug       60

accgggagcu ccagcggcuc caagcucaag gaccccgagc ugagccugaa ggggacgcag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggggaggc ggcccacaag      180

uggucccugc cggagauggu gagcaaggag uccgagcggc ugagcaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcagc acccugacgc ugaacaccgc ccaggccaac      300

cacaccgggu ucuacuccug caaguaccuc gcggugccca ccagcaagaa gaaggagacg      360

gaguccgcca ucuacaucuu caucagcgac accggccggc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag gggcgcgagc uggugauccc gugccgggug      480

accagcccca acaucacggu cacccugaag aagaagaagg ccuga                      525


<210>  3817
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       VEGFR1__Homo_sapiens__ACF47598

<400>  3817
auggucuccu acugggacac cggcguccuc cucugcgccc uccucuccug ccuccuccuc       60

accggcuccu ccuccggcuc caagcucaag gaccccgagc ucucccucaa gggcacccag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggcgaggc cgcccacaag      180

uggucccucc ccgagauggu cuccaaggag uccgagcgcc ucuccaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcucc acccucaccc ucaacaccgc ccaggccaac      300

cacaccggcu ucuacuccug caaguaccuc gccgucccca ccuccaagaa gaaggagacc      360

gaguccgcca ucuacaucuu caucuccgac accggccgcc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag ggccgcgagc ucgucauccc cugccgcguc      480

accuccccca acaucaccgu cacccucaag aagaagaagg ccuga                      525


<210>  3818
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       VEGFR1__Homo_sapiens__ACF47598

<400>  3818
auggugagcu acugggacac cggcguccug cucugcgccc uucuguccug uuuguuacug       60

acagggucuu caaguggaag caagcuaaaa gaucccgagc ucucccugaa ggguacucag      120

cacaucaugc aagcuggcca gacgcuucau cugcagugca gaggggaagc agcccacaaa      180

uggucuuugc cugagauggu uucgaaggaa ucagagaggc ucagcauuac caaaagugcg      240

uguggacgga acggcaagca guucugcucc acacugacuc ugaauaccgc ucaagccaac      300

cauacagguu uuuauucuug uaaguaccuc gcagugccaa ccagcaaaaa gaaagaaacu      360

gaguccgcca uauauaucuu cauuucagac acagggcgcc cguuuguaga gauguacagu      420

gaaauccccg agauuaucca caugaccgaa ggacgagagu uagugauacc uugccguguc      480

acgagcccaa auaucacugu gacccugaag aaaaagaagg cuuga                      525


<210>  3819
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       VEGFR1__Homo_sapiens__ACF47598

<400>  3819
auggugagcu acugggacac cggcgugcug cugugcgccc ugcugagcug ccugcugcug       60

accggcagca gcagcggcag caagcugaag gaccccgagc ugagccugaa gggcacccag      120

cacaucaugc aggccggcca gacccugcac cugcagugca gaggcgaggc cgcccacaag      180

uggagccugc ccgagauggu gagcaaggag agcgagagac ugagcaucac caagagcgcc      240

ugcggcagaa acggcaagca guucugcagc acccugaccc ugaacaccgc ccaggccaac      300

cacaccggcu ucuacagcug caaguaccug gccgugccca ccagcaagaa gaaggagacc      360

gagagcgcca ucuacaucuu caucagcgac accggcagac ccuucgugga gauguacagc      420

gagauccccg agaucaucca caugaccgag ggcagagagc uggugauccc cugcagagug      480

accagcccca acaucaccgu gacccugaag aagaagaagg ccuga                      525


<210>  3820
<211>  525
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       VEGFR1__Homo_sapiens__ACF47598

<400>  3820
auggugagcu acugggacac cggcguccug cucugcgccc ugcuuuccug ucugcuccug       60

acagggucua gcuccggauc uaaacuuaag gaucccgagc ugagccucaa gggcacgcag      120

cacaucaugc aagcugggca gacccugcau cugcagugca gaggagaagc cgcgcacaaa      180

uggucccucc cugagauggu uucuaaggaa agcgagcggc uguccauuac aaaaagcgcu      240

uguggccgca acgggaagca guucugcucu acccuuacac ugaauaccgc ccaagccaac      300

cauacaggau uuuauuccug uaaguaccuc gcugugccga ccagcaaaaa gaaagaaacg      360

gagucugcca ucuauauuuu caucuccgac accggcagac ccuuugugga gauguacagc      420

gaaauuccug agaucaucca caugacagaa ggccgggagc uggucauucc cugccgcgug      480

accucuccua auaucacagu uacccuuaag aaaaagaagg cuuga                      525


<210>  3821
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__A0A0H5AUY0

<400>  3821

Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu Pro Ala Val Pro 
1               5                   10                  15      


Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly Ala Ala 
            20                  25                  30          


Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser Ala Tyr 
        35                  40                  45              


Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp Gly Gly 
65                  70                  75                  80  


Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe Thr Val His Phe 
                85                  90                  95      


Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg Tyr Gly Pro Phe 
            100                 105                 110         


Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe 
        115                 120                 125             


Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile 
    130                 135                 140                 


Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 
145                 150                 155                 160 


Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 
                165                 170                 175     


Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 
            180                 185                 190         


Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 
        195                 200                 205             


Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 
    210                 215                 220                 


Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 
225                 230                 235                 240 


Met Asn Leu Gly Ala Thr Leu Lys Gly 
                245                 


<210>  3822
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__BAR92607

<400>  3822
augggcuccg acgugcggga ccugaacgcg cugcugcccg ccguccccuc ccuggguggc       60

ggcggcggcu gugcccugcc ugugagcggc gcggcgcagu gggcgccggu gcuggacuuu      120

gcgcccccgg gcgcuucggc uuacgggucg uugggcggcc ccgcgccgcc accggcuccg      180

ccgccacccc cgccgccgcc gccucacucc uucaucaaac aggagccgag cuggggcggc      240

gcggagccgc acgaggagca gugccugagc gccuucacug uccacuuuuc cggccaguuc      300

acuggcacag ccggagccug ucgcuacggg cccuucgguc cuccuccgcc cagccaggcg      360

ucauccggcc aggccaggau guuuccuaac gcgcccuacc ugcccagcug ccucgagagc      420

cagcccgcua uucgcaauca ggguuacagc acggucaccu ucgacgggac gcccagcuac      480

ggucacacgc ccucgcacca ugcggcgcag uuccccaacc acucauucaa gcaugaggau      540

cccaugggcc agcagggcuc gcugggugag cagcaguacu cggugccgcc cccggucuau      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cuuugcugcu gaggacgccc      660

uacagcagug acaauuuaua ccaaaugaca ucccagcuug aaugcaugac cuggaaucag      720

augaacuuag gagccaccuu aaagggguaa                                       750


<210>  3823
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       WT1__Homo_sapiens__BAR92607

<400>  3823
augggcagcg acgugcgcga ccugaacgcc cuccugcccg ccguccccuc ccucgggggc       60

gggggcgggu gcgcgcugcc cgugagcggc gccgcccagu gggcccccgu gcuggacuuc      120

gcgccgcccg gcgccuccgc cuacgggagc cugggcgggc ccgcgccccc gcccgcgccc      180

ccgcccccgc ccccgccccc gccccacucc uucaucaagc aggagcccag cuggggcggg      240

gccgagcccc acgaggagca gugccucucc gccuucaccg uccacuucag cggccaguuc      300

accggcacgg ccggggccug ccgguacggc cccuucgggc cgccgccgcc cucccaggcc      360

agcuccggcc aggcccgcau guuccccaac gcccccuacc ugcccagcug ccuggagucc      420

cagcccgcca uccggaacca gggcuacagc accgugaccu ucgacgggac ccccuccuac      480

ggccacacgc ccagccacca cgccgcccag uuccccaacc acuccuucaa gcacgaggac      540

cccauggggc agcagggcag ccucggggag cagcaguacu ccgugccccc gcccgucuac      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cgcugcugcu ccgcacgccc      660

uacuccagcg acaaccugua ccagaugacc ucccagcugg agugcaugac cuggaaccag      720

augaaccucg gggccacccu gaagggcuga                                       750


<210>  3824
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       WT1__Homo_sapiens__BAR92607

<400>  3824
augggcuccg acguccgcga ccucaacgcc cuccuccccg ccguccccuc ccucggcggc       60

ggcggcggcu gcgcccuccc cgucuccggc gccgcccagu gggcccccgu ccucgacuuc      120

gccccccccg gcgccuccgc cuacggcucc cucggcggcc ccgccccccc ccccgccccc      180

cccccccccc cccccccccc cccccacucc uucaucaagc aggagcccuc cuggggcggc      240

gccgagcccc acgaggagca gugccucucc gccuucaccg uccacuucuc cggccaguuc      300

accggcaccg ccggcgccug ccgcuacggc cccuucggcc cccccccccc cucccaggcc      360

uccuccggcc aggcccgcau guuccccaac gcccccuacc uccccuccug ccucgagucc      420

cagcccgcca uccgcaacca gggcuacucc accgucaccu ucgacggcac ccccuccuac      480

ggccacaccc ccucccacca cgccgcccag uuccccaacc acuccuucaa gcacgaggac      540

cccaugggcc agcagggcuc ccucggcgag cagcaguacu ccgucccccc ccccgucuac      600

ggcugccaca cccccaccga cuccugcacc ggcucccagg cccuccuccu ccgcaccccc      660

uacuccuccg acaaccucua ccagaugacc ucccagcucg agugcaugac cuggaaccag      720

augaaccucg gcgccacccu caagggcuga                                       750


<210>  3825
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       WT1__Homo_sapiens__BAR92607

<400>  3825
augggcagcg acgugagaga ucugaacgcc cuccuucccg cugucccuuc ccugggaggg       60

gguggcgggu gcgcauugcc aguuucugga gccgcgcagu gggcuccggu guuagacuuc      120

gcacccccug gcgccucagc cuacgguagu cuagggggac cagcuccccc uccagcaccc      180

ccuccaccgc ccccuccacc cccucacagc uuuaucaagc aagagccauc cuggggcggc      240

gccgaacccc augaggaaca gugucugucu gcuuucaccg uacacuuuuc ggggcaguuc      300

acaggaacug ccggugcgug cagguauggc ccguuugggc cucccccacc uucacaggca      360

agcaguggac aagcccggau guuccccaau gcuccauacc uccccuccug ucuggagucu      420

cagccugcca uucgcaacca gggcuauagc acggugaccu uugaugguac accauccuac      480

gggcauacuc cgucacacca ugcagcucag uuccccaauc acaguuuuaa acacgaagac      540

ccuaugggac aacagggcag ccuuggcgag cagcaguauu cugucccacc cccuguguac      600

gggugccaua ccccaacaga uuccuguacc ggaucacaag cccuguugcu ccgaacuccc      660

uauagcagug acaaccugua ccagaugaca ucucagcugg agugcaugac cuggaaucaa      720

augaaccucg gugcgacguu aaagggcuga                                       750


<210>  3826
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       WT1__Homo_sapiens__BAR92607

<400>  3826
augggcagcg acgugagaga ccugaacgcc cugcugcccg ccgugcccag ccugggcggc       60

ggcggcggcu gcgcccugcc cgugagcggc gccgcccagu gggcccccgu gcuggacuuc      120

gccccccccg gcgccagcgc cuacggcagc cugggcggcc ccgccccccc ccccgccccc      180

cccccccccc cccccccccc cccccacagc uucaucaagc aggagcccag cuggggcggc      240

gccgagcccc acgaggagca gugccugagc gccuucaccg ugcacuucag cggccaguuc      300

accggcaccg ccggcgccug cagauacggc cccuucggcc cccccccccc cagccaggcc      360

agcagcggcc aggccagaau guuccccaac gcccccuacc ugcccagcug ccuggagagc      420

cagcccgcca ucagaaacca gggcuacagc accgugaccu ucgacggcac ccccagcuac      480

ggccacaccc ccagccacca cgccgcccag uuccccaacc acagcuucaa gcacgaggac      540

cccaugggcc agcagggcag ccugggcgag cagcaguaca gcgugccccc ccccguguac      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cccugcugcu gagaaccccc      660

uacagcagcg acaaccugua ccagaugacc agccagcugg agugcaugac cuggaaccag      720

augaaccugg gcgccacccu gaagggcuga                                       750


<210>  3827
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       WT1__Homo_sapiens__BAR92607

<400>  3827
augggcagcg acgugagaga ucugaacgcc cuccugcccg cugucccuuc ccuuggggga       60

ggcgggggau gcgcccugcc gguuucuggc gcggcucagu gggcccccgu gcucgacuuc      120

gccccucccg gggcuagcgc cuacggaucc cugggcggcc cugcuccccc uccggcgccc      180

ccucccccuc ccccgccucc cccucacucu uuuaucaagc aagagcccag cuggggaggg      240

gccgaacccc augaggaaca gugucuuucc gccuucaccg ugcacuuuuc uggccaguuc      300

acagggacgg cuggagccug ccgguauggc ccuuuugggc cgcccccucc cagccaggcu      360

uccagcggac aagcccgcau guucccuaau gcgcccuacc ugccgucuug ucucgagucc      420

cagccugcca uuagaaacca gggcuauagc accgucacau uugauggcac ccccucuuac      480

gggcauacac cuucccacca ugcugcccag uuccccaauc acagcuuuaa acacgaagac      540

ccuaugggac aacagggcuc ucugggggag cagcaguauu ccgugccccc gccuguuuac      600

ggaugccaua cccccacaga uagcuguacc ggcucccaag cucugcuccu gcggacgccc      660

uauucuagcg acaaccuuua ccagaugacc ucccagcugg agugcaugac auggaaucaa      720

augaaccucg gggccacccu gaagggauga                                       750


<210>  3828
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__P19544

<400>  3828

Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu Pro Ala Val Pro 
1               5                   10                  15      


Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly Ala Ala 
            20                  25                  30          


Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser Ala Tyr 
        35                  40                  45              


Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp Gly Gly 
65                  70                  75                  80  


Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe Thr Val His Phe 
                85                  90                  95      


Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg Tyr Gly Pro Phe 
            100                 105                 110         


Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe 
        115                 120                 125             


Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile 
    130                 135                 140                 


Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 
145                 150                 155                 160 


Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 
                165                 170                 175     


Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 
            180                 185                 190         


Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 
        195                 200                 205             


Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 
    210                 215                 220                 


Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 
225                 230                 235                 240 


Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala Gly Ser Ser Ser 
                245                 250                 255     


Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser Thr Gly Tyr Glu 
            260                 265                 270         


Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala Gln Tyr Arg Ile 
        275                 280                 285             


His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg Arg Val Pro 
    290                 295                 300                 


Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu Thr Ser Glu Lys 
305                 310                 315                 320 


Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys 
                325                 330                 335     


Leu Ser His Leu Gln Met His Ser Arg Lys His Thr Gly Glu Lys Pro 
            340                 345                 350         


Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser Arg Ser Asp 
        355                 360                 365             


Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys Pro Phe Gln 
    370                 375                 380                 


Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp His Leu Lys Thr 
385                 390                 395                 400 


His Thr Arg Thr His Thr Gly Lys Thr Ser Glu Lys Pro Phe Ser Cys 
                405                 410                 415     


Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val 
            420                 425                 430         


Arg His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala 
        435                 440                 445             


Leu 
    


<210>  3829
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__AAA61299

<400>  3829
augggcuccg acgugcggga ccugaacgcg cugcugcccg ccguccccuc ccuggguggc       60

ggcggcggcu gugcccugcc ugugagcggc gcggcgcagu gggcgccggu gcuggacuuu      120

gcgcccccgg gcgcuucggc uuacgggucg uugggcggcc ccgcgccgcc accggcuccg      180

ccgccacccc cgccgccgcc gccucacucc uucaucaaac aggagccgag cuggggcggc      240

gcggagccgc acgaggagca gugccugagc gccuucacug uccacuuuuc cggccaguuc      300

acuggcacag ccggagccug ucgcuacggg cccuucgguc cuccuccgcc cagccaggcg      360

ucauccggcc aggccaggau guuuccuaac gcgcccuacc ugcccagcug ccucgagagc      420

cagcccgcua uucgcaauca ggguuacagc acggucaccu ucgacgggac gcccagcuac      480

ggucacacgc ccucgcacca ugcggcgcag uuccccaacc acucauucaa gcaugaggau      540

cccaugggcc agcagggcuc gcugggugag cagcaguacu cggugccgcc cccggucuau      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cuuugcugcu gaggacgccc      660

uacagcagug acaauuuaua ccaaaugaca ucccagcuug aaugcaugac cuggaaucag      720

augaacuuag gagccaccuu aaagggaguu gcugcuggga gcuccagcuc agugaaaugg      780

acagaagggc agagcaacca cagcacaggg uacgagagcg auaaccacac aacgcccauc      840

cucugcggag cccaauacag aauacacacg cacggugucu ucagaggcau ucaggaugug      900

cgacgugugc cuggaguagc cccgacucuu guacggucgg caucugagac cagugagaaa      960

cgccccuuca ugugugcuua cccaggcugc aauaagagau auuuuaagcu gucccacuua     1020

cagaugcaca gcaggaagca cacuggugag aaaccauacc agugugacuu caaggacugu     1080

gaacgaaggu uuucucguuc agaccagcuc aaaagacacc aaaggagaca uacaggugug     1140

aaaccauucc aguguaaaac uugucagcga aaguucuccc gguccgacca ccugaagacc     1200

cacaccagga cucauacagg uaaaacaagu gaaaagcccu ucagcugucg guggccaagu     1260

ugucagaaaa aguuugcccg gucagaugaa uuaguccgcc aucacaacau gcaucagaga     1320

aacaugacca aacuccagcu ggcgcuuuga                                      1350


<210>  3830
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       WT1__Homo_sapiens__AAA61299

<400>  3830
augggcagcg acgugcgcga ccugaacgcc cuccugcccg ccgucccguc ccucgggggc       60

gggggcgggu gcgcgcugcc cgugagcggc gccgcccagu gggcccccgu gcuggacuuc      120

gcgccgcccg gcgccuccgc cuacgggagc cugggcgggc ccgcgccccc gcccgcgccc      180

ccgcccccgc ccccgccccc gccccacucc uucaucaagc aggagcccag cuggggcggg      240

gccgagcccc acgaggagca gugccucucc gccuucaccg uccacuucag cggccaguuc      300

accggcacgg ccggggccug ccgguacggc cccuucgggc ccccgccgcc cucccaggcc      360

agcuccggcc aggcccgcau guuccccaac gcccccuacc ugcccagcug ccuggagucc      420

cagcccgcca uccggaacca gggcuacagc accgugaccu ucgacgggac ccccuccuac      480

ggccacacgc ccagccacca cgccgcccag uuccccaacc acuccuucaa gcacgaggac      540

cccauggggc agcagggcag ccucggggag cagcaguacu ccgugccgcc gcccgucuac      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cgcugcugcu ccgcacgccc      660

uacuccagcg acaaccugua ccagaugacc ucccagcugg agugcaugac cuggaaccag      720

augaaccucg gggccacccu gaagggcgug gccgccggga gcuccagcuc cgugaagugg      780

acggagggcc agagcaacca cuccaccggg uacgagagcg acaaccacac cacccccauc      840

cugugcggcg cccaguaccg gauccacacg cacggcgucu uccgcgggau ccaggacgug      900

cggcgcgugc ccggcgucgc gcccacccuc gugcgguccg ccagcgagac cuccgagaag      960

cgccccuuca ugugcgccua ccccgggugc aacaagcggu acuucaagcu gagccaccuc     1020

cagaugcacu cccgcaagca caccggcgag aagccguacc agugcgacuu caaggacugc     1080

gagcggcgcu ucagccgguc cgaccagcug aagcgccacc agcggcgcca cacgggggug     1140

aagcccuucc agugcaagac cugccagcgg aaguucagcc gcuccgacca ccugaagacc     1200

cacacccgga cgcacaccgg caagaccagc gagaagcccu ucagcugccg cuggcccucc     1260

ugccagaaga aguucgcccg cagcgacgag cugguccggc accacaacau gcaccagcgc     1320

aacaugacca agcuccagcu ggcccuguga                                      1350


<210>  3831
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       WT1__Homo_sapiens__AAA61299

<400>  3831
augggcuccg acguccgcga ccucaacgcc cuccuccccg ccguccccuc ccucggcggc       60

ggcggcggcu gcgcccuccc cgucuccggc gccgcccagu gggcccccgu ccucgacuuc      120

gccccccccg gcgccuccgc cuacggcucc cucggcggcc ccgccccccc ccccgccccc      180

cccccccccc cccccccccc cccccacucc uucaucaagc aggagcccuc cuggggcggc      240

gccgagcccc acgaggagca gugccucucc gccuucaccg uccacuucuc cggccaguuc      300

accggcaccg ccggcgccug ccgcuacggc cccuucggcc cccccccccc cucccaggcc      360

uccuccggcc aggcccgcau guuccccaac gcccccuacc uccccuccug ccucgagucc      420

cagcccgcca uccgcaacca gggcuacucc accgucaccu ucgacggcac ccccuccuac      480

ggccacaccc ccucccacca cgccgcccag uuccccaacc acuccuucaa gcacgaggac      540

cccaugggcc agcagggcuc ccucggcgag cagcaguacu ccgucccccc ccccgucuac      600

ggcugccaca cccccaccga cuccugcacc ggcucccagg cccuccuccu ccgcaccccc      660

uacuccuccg acaaccucua ccagaugacc ucccagcucg agugcaugac cuggaaccag      720

augaaccucg gcgccacccu caagggcguc gccgccggcu ccuccuccuc cgucaagugg      780

accgagggcc aguccaacca cuccaccggc uacgaguccg acaaccacac cacccccauc      840

cucugcggcg cccaguaccg cauccacacc cacggcgucu uccgcggcau ccaggacguc      900

cgccgcgucc ccggcgucgc ccccacccuc guccgcuccg ccuccgagac cuccgagaag      960

cgccccuuca ugugcgccua ccccggcugc aacaagcgcu acuucaagcu cucccaccuc     1020

cagaugcacu cccgcaagca caccggcgag aagcccuacc agugcgacuu caaggacugc     1080

gagcgccgcu ucucccgcuc cgaccagcuc aagcgccacc agcgccgcca caccggcguc     1140

aagcccuucc agugcaagac cugccagcgc aaguucuccc gcuccgacca ccucaagacc     1200

cacacccgca cccacaccgg caagaccucc gagaagcccu ucuccugccg cuggcccucc     1260

ugccagaaga aguucgcccg cuccgacgag cucguccgcc accacaacau gcaccagcgc     1320

aacaugacca agcuccagcu cgcccucuga                                      1350


<210>  3832
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       WT1__Homo_sapiens__AAA61299

<400>  3832
augggcagcg acgugagaga ucugaacgcc cuccuucccg cugucccuuc ccugggaggg       60

gguggcgggu gcgcauugcc aguuucugga gccgcgcagu gggcuccggu guuagacuuc      120

gcacccccug gcgccucagc cuacgguagu cuagggggac cagcuccccc uccagcaccc      180

ccuccaccgc ccccuccacc cccucacagc uuuaucaagc aagagccauc cuggggcggc      240

gccgaacccc augaggaaca gugucugucu gcuuucaccg uacacuuuuc ggggcaguuc      300

acaggaacug ccggugcgug cagguauggc ccguuugggc cucccccacc uucacaggca      360

agcaguggac aagcccggau guuccccaau gcuccauacc uccccuccug ucuggagucu      420

cagccugcca uucgcaacca gggcuauagc acggugaccu uugaugguac accauccuac      480

gggcauacuc cgucacacca ugcagcucag uuccccaauc acaguuuuaa acacgaagac      540

ccuaugggac aacagggcag ccuuggcgag cagcaguauu cugucccacc cccuguguac      600

gggugccaua ccccaacaga uuccuguacc ggaucacaag cccuguugcu ccgaacuccc      660

uauagcagug acaaccugua ccagaugaca ucucagcugg agugcaugac cuggaaucaa      720

augaaccucg gugcgacguu aaagggcguu gccgcagggu ccagcucguc ugugaaaugg      780

acugaaggac aguccaauca cucaaccggc uacgagagug auaaccauac aacuccgaua      840

cuguguggug cucaguaucg uauccacacc cacggggucu ucagaggcau ucaggacgug      900

aggcggguac cuggaguugc cccaacacuu gugcgcagcg cuuccgaaac cucugagaag      960

agacccuuua ugugcgccua cccuggcugu aauaaaaggu auuucaaguu gagccaucug     1020

caaaugcacu cacggaagca uacgggggag aaacccuacc agugcgauuu uaaggacugu     1080

gaacgccgau ucaguagauc cgaucagcua aaaaggcacc agcggcguca uacuggaguc     1140

aagccauucc aaugcaaaac augccagcgc aaguuuagca gaucugacca ccucaagacc     1200

cacacuagga cacauaccgg uaaaacguca gagaagccuu ucaguugucg guggcccagc     1260

ugccagaaaa aguuugcacg auccgaugaa cuggugcgcc accauaacau gcaccagaga     1320

aauaugacca aacuucaacu ggccuuguga                                      1350


<210>  3833
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       WT1__Homo_sapiens__AAA61299

<400>  3833
augggcagcg acgugagaga ccugaacgcc cugcugcccg ccgugcccag ccugggcggc       60

ggcggcggcu gcgcccugcc cgugagcggc gccgcccagu gggcccccgu gcuggacuuc      120

gccccccccg gcgccagcgc cuacggcagc cugggcggcc ccgccccccc ccccgccccc      180

cccccccccc cccccccccc cccccacagc uucaucaagc aggagcccag cuggggcggc      240

gccgagcccc acgaggagca gugccugagc gccuucaccg ugcacuucag cggccaguuc      300

accggcaccg ccggcgccug cagauacggc cccuucggcc cccccccccc cagccaggcc      360

agcagcggcc aggccagaau guuccccaac gcccccuacc ugcccagcug ccuggagagc      420

cagcccgcca ucagaaacca gggcuacagc accgugaccu ucgacggcac ccccagcuac      480

ggccacaccc ccagccacca cgccgcccag uuccccaacc acagcuucaa gcacgaggac      540

cccaugggcc agcagggcag ccugggcgag cagcaguaca gcgugccccc ccccguguac      600

ggcugccaca cccccaccga cagcugcacc ggcagccagg cccugcugcu gagaaccccc      660

uacagcagcg acaaccugua ccagaugacc agccagcugg agugcaugac cuggaaccag      720

augaaccugg gcgccacccu gaagggcgug gccgccggca gcagcagcag cgugaagugg      780

accgagggcc agagcaacca cagcaccggc uacgagagcg acaaccacac cacccccauc      840

cugugcggcg cccaguacag aauccacacc cacggcgugu ucagaggcau ccaggacgug      900

agaagagugc ccggcguggc ccccacccug gugagaagcg ccagcgagac cagcgagaag      960

agacccuuca ugugcgccua ccccggcugc aacaagagau acuucaagcu gagccaccug     1020

cagaugcaca gcagaaagca caccggcgag aagcccuacc agugcgacuu caaggacugc     1080

gagagaagau ucagcagaag cgaccagcug aagagacacc agagaagaca caccggcgug     1140

aagcccuucc agugcaagac cugccagaga aaguucagca gaagcgacca ccugaagacc     1200

cacaccagaa cccacaccgg caagaccagc gagaagcccu ucagcugcag auggcccagc     1260

ugccagaaga aguucgccag aagcgacgag cuggugagac accacaacau gcaccagaga     1320

aacaugacca agcugcagcu ggcccuguga                                      1350


<210>  3834
<211>  1350
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       WT1__Homo_sapiens__AAA61299

<400>  3834
augggcagcg acgugagaga ucugaacgcc cuccugcccg cugucccuuc ccuuggggga       60

ggcgggggau gcgcccugcc gguuucuggc gcggcucagu gggcccccgu gcucgacuuc      120

gccccucccg gggcuagcgc cuacggaucc cugggcggcc cugcuccccc uccggcgccc      180

ccucccccuc ccccgccucc cccucacucu uuuaucaagc aagagcccag cuggggaggg      240

gccgaacccc augaggaaca gugucuuucc gccuucaccg ugcacuuuuc uggccaguuc      300

acagggacgg cuggagccug ccgguauggc ccuuuugggc cgcccccucc cagccaggcu      360

uccagcggac aagcccgcau guucccuaau gcgcccuacc ugccgucuug ucucgagucc      420

cagccugcca uuagaaacca gggcuauagc accgucacau uugauggcac ccccucuuac      480

gggcauacac cuucccacca ugcugcccag uuccccaauc acagcuuuaa acacgaagac      540

ccuaugggac aacagggcuc ucugggggag cagcaguauu ccgugccccc gccuguuuac      600

ggaugccaua cccccacaga uagcuguacc ggcucccaag cucugcuccu gcggacgccc      660

uauucuagcg acaaccuuua ccagaugacc ucccagcugg agugcaugac auggaaucaa      720

augaaccucg gggccacccu gaagggagug gccgcuggcu cuagcuccag cgucaaaugg      780

acagaaggcc agucuaauca cagcaccggg uacgaguccg auaaccauac gacaccuauc      840

cuuuguggag cgcaguaucg cauucacacc cacggcgugu ucagagggau ccaggacguu      900

cggcgcgugc cgggagucgc ccccacacug gugagaucug cuagcgaaac cuccgagaag      960

cggccuuuua ugugcgccua ccccggcugu aauaaacgcu auuucaagcu cagccaucug     1020

caaaugcacu cuagaaagca uaccggggag aaaccuuacc agugcgauuu uaaggacugu     1080

gaacggcgcu ucuccagaag cgaucagcug aaacggcacc agcgcagaca uacaggcgug     1140

aagcccuucc aaugcaaaac gugccagcgg aaguuuucua gauccgacca ccucaagacc     1200

cacacacgca cccauacagg aaaaaccagc gagaagccuu ucuccugucg guggcccucu     1260

ugccagaaaa aguuugccag aagcgaugaa cugguccgcc accauaacau gcaccagcgg     1320

aauaugacga aacuucaacu ggcucucuga                                      1350


<210>  3835
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__Q06250

<400>  3835

Met Gln Arg Arg Gly Gln Pro Leu Glu Asn His Val Ala Leu Ile His 
1               5                   10                  15      


Trp Gln Ser Ala Gly Ile Pro Ala Ser Lys Val His Asn Tyr Cys Asn 
            20                  25                  30          


Met Lys Lys Ser Arg Leu Gly Arg Ser Arg Ala Val Arg Ile Ser Gln 
        35                  40                  45              


Pro Leu Leu Ser Pro Arg Arg Cys Pro Leu His Leu Thr Glu Arg Gly 
    50                  55                  60                  


Ala Gly Leu Leu Gln Pro Gln Pro Gln Gly Pro Val Arg Thr Pro Gly 
65                  70                  75                  80  


Pro Pro Ser Gly Ser His Pro Ala Ala Ala Asp Asn 
                85                  90          


<210>  3836
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  WT1__Homo_sapiens__AAA63269

<400>  3836
augcagaggc gaggacagcc ccuggaaaac cauguggcgu ugauacacug gcaaagcgca       60

ggcaucccgg ccucgaaggu gcauaauuau ugcaauauga aaaaaucgag gcuggguagg      120

agcagggcag ugaggauuuc ucaacccuua cuuucacccc ggcgcugucc acugcaucug      180

acagagcgcg gagcugggcu gcuacagccg caaccccagg gaccagugcg cacgccuggg      240

ccgcccuccg ggagucaccc agcggccgcg gacaacuga                             279


<210>  3837
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       WT1__Homo_sapiens__AAA63269

<400>  3837
augcagcgcc ggggccagcc ccuggagaac cacguggccc ucauccacug gcagagcgcc       60

gggaucccgg cguccaaggu ccacaacuac ugcaacauga agaagucccg ccugggccgg      120

ucccgcgccg ugcggaucag ccagccccug cucagccccc gccggugccc ccugcaccug      180

accgagcgcg gggccggccu ccugcagccg cagccccagg ggcccgugcg gacccccggc      240

ccgcccagcg gcucccaccc cgccgccgcg gacaacuga                             279


<210>  3838
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       WT1__Homo_sapiens__AAA63269

<400>  3838
augcagcgcc gcggccagcc ccucgagaac cacgucgccc ucauccacug gcaguccgcc       60

ggcauccccg ccuccaaggu ccacaacuac ugcaacauga agaagucccg ccucggccgc      120

ucccgcgccg uccgcaucuc ccagccccuc cucucccccc gccgcugccc ccuccaccuc      180

accgagcgcg gcgccggccu ccuccagccc cagccccagg gccccguccg cacccccggc      240

ccccccuccg gcucccaccc cgccgccgcc gacaacuga                             279


<210>  3839
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       WT1__Homo_sapiens__AAA63269

<400>  3839
augcagagaa ggggccaacc ccuggagaac cacguggccc ucauccauug gcagagcgcu       60

gggauuccug cauccaaggu ccacaauuac ugcaacauga aaaagucucg gcuuggacgc      120

ucacgagccg uucguauaag ucagccacug uugagcccga gaaggugucc cuuacaucug      180

accgaacggg gugcgggccu acuccagccu caaccacagg ggcccgugcg cacaccugga      240

ccacccuccg gcucucaccc ugcugccgca gacaauuga                             279


<210>  3840
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       WT1__Homo_sapiens__AAA63269

<400>  3840
augcagagaa gaggccagcc ccuggagaac cacguggccc ugauccacug gcagagcgcc       60

ggcauccccg ccagcaaggu gcacaacuac ugcaacauga agaagagcag acugggcaga      120

agcagagccg ugagaaucag ccagccccug cugagcccca gaagaugccc ccugcaccug      180

accgagagag gcgccggccu gcugcagccc cagccccagg gccccgugag aacccccggc      240

ccccccagcg gcagccaccc cgccgccgcc gacaacuga                             279


<210>  3841
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       WT1__Homo_sapiens__AAA63269

<400>  3841
augcagagac ggggccaacc ccuggagaac cacguggccc ucauccauug gcagagcgcu       60

gggauuccug ccuccaaggu ccacaauuac ugcaacauga aaaagucucg ccugggaaga      120

agccgggcgg uucgcaucuc ccagccgcuu cugucuccca gacggugucc ucuccaucug      180

accgaacgcg gcgcugggcu ucugcagccc caaccucagg gacccgugag aacaccuggc      240

ccgcccagcg ggucccaccc ugccgccgcu gacaauuga                             279


<210>  3842
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  XAGE1__Homo_sapiens__Q9HD64

<400>  3842

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  3843
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  XAGE1__Homo_sapiens__AAP35763

<400>  3843
auggagagcc ccaaaaagaa gaaccagcag cugaaagucg ggauccuaca ccugggcagc       60

agacagaaga agaucaggau acagcugaga ucccagugcg cgacauggaa ggugaucugc      120

aagagcugca ucagucaaac accggggaua aaucuggauu uggguuccgg cgucaaggug      180

aagauaauac cuaaagagga acacuguaaa augccagaag caggugaaga gcaaccacaa      240

guuuag                                                                 246


<210>  3844
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       XAGE1__Homo_sapiens__AAP35763

<400>  3844
auggagagcc ccaagaagaa gaaccagcag cugaaggugg gcauccucca ccuggggucc       60

cgccagaaga agauccggau ccagcugcgc agccagugcg ccaccuggaa ggucaucugc      120

aaguccugca ucagccagac cccgggcauc aaccucgacc ugggguccgg cgugaaggug      180

aagaucaucc ccaaggagga gcacugcaag augcccgagg ccggggagga gcagccccag      240

gucuga                                                                 246


<210>  3845
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       XAGE1__Homo_sapiens__AAP35763

<400>  3845
auggaguccc ccaagaagaa gaaccagcag cucaaggucg gcauccucca ccucggcucc       60

cgccagaaga agauccgcau ccagcuccgc ucccagugcg ccaccuggaa ggucaucugc      120

aaguccugca ucucccagac ccccggcauc aaccucgacc ucggcuccgg cgucaagguc      180

aagaucaucc ccaaggagga gcacugcaag augcccgagg ccggcgagga gcagccccag      240

gucuga                                                                 246


<210>  3846
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       XAGE1__Homo_sapiens__AAP35763

<400>  3846
auggagagcc ccaagaaaaa gaaccagcaa cugaaagugg gcauccucca ccuugggucc       60

agacagaaga aaauuaggau acagcugcgg ucucagugcg ccaccuggaa ggucaucugu      120

aagucaugca uuagucaaac accuggaauc aauuuggacu uagguagcgg cguuaaagug      180

aagauuaucc caaaagagga acauuguaag augccggaag cuggggagga acagccccag      240

guauga                                                                 246


<210>  3847
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       XAGE1__Homo_sapiens__AAP35763

<400>  3847
auggagagcc ccaagaagaa gaaccagcag cugaaggugg gcauccugca ccugggcagc       60

agacagaaga agaucagaau ccagcugaga agccagugcg ccaccuggaa ggugaucugc      120

aagagcugca ucagccagac ccccggcauc aaccuggacc ugggcagcgg cgugaaggug      180

aagaucaucc ccaaggagga gcacugcaag augcccgagg ccggcgagga gcagccccag      240

guguga                                                                 246


<210>  3848
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       XAGE1__Homo_sapiens__AAP35763

<400>  3848
auggagagcc ccaagaaaaa gaaccagcaa cugaaagugg gcauccucca ccuggggucc       60

agacagaaga aaauucggau ccagcuucgc ucucagugcg ccaccuggaa ggucauuugu      120

aagagcugca ucucccaaac accuggaauu aaucuggacc ucggcucugg gguuaaagug      180

aagaucaucc cgaaagagga acauuguaag augcccgaag cuggagagga acagccucag      240

guguga                                                                 246


<210>  3849
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  4-1BBL__Homo_sapiens__P41273

<400>  3849

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  3850
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  4-1BBL__Homo_sapiens__AAA53134

<400>  3850
auggaauacg ccucugacgc uucacuggac cccgaagccc cguggccucc cgcgccccgc       60

gcucgcgccu gccgcguacu gccuugggcc cuggucgcgg ggcugcugcu gcugcugcug      120

cucgcugccg ccugcgccgu cuuccucgcc ugccccuggg ccguguccgg ggcucgcgcc      180

ucgcccggcu ccgcggccag cccgagacuc cgcgaggguc ccgagcuuuc gcccgacgau      240

cccgccggcc ucuuggaccu gcggcagggc auguuugcgc agcugguggc ccaaaauguu      300

cugcugaucg augggccccu gagcugguac agugacccag gccuggcagg cgugucccug      360

acggggggcc ugagcuacaa agaggacacg aaggagcugg ugguggccaa ggcuggaguc      420

uacuaugucu ucuuucaacu agagcugcgg cgcguggugg ccggcgaggg cucaggcucc      480

guuucacuug cgcugcaccu gcagccacug cgcucugcug cuggggccgc cgcccuggcu      540

uugaccgugg accugccacc cgccuccucc gaggcucgga acucggccuu cgguuuccag      600

ggccgcuugc ugcaccugag ugccggccag cgccugggcg uccaucuuca cacugaggcc      660

agggcacgcc augccuggca gcuuacccag ggcgccacag ucuugggacu cuuccgggug      720

acccccgaaa ucccagccgg acucccuuca ccgaggucgg aauaa                      765


<210>  3851
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3851
auggaguacg ccagcgacgc cucccuggac cccgaggcgc cguggccgcc cgcgccccgc       60

gcccgggccu gccgcgugcu ccccugggcc cuggucgccg gccugcuccu gcugcuccug      120

cuggccgccg ccugcgcggu guuccucgcc ugccccuggg ccgugagcgg ggcccgggcc      180

ucccccggca gcgcggccag cccccgccug cgggaggggc cggagcuguc ccccgacgac      240

cccgccggcc uccuggaccu gcgccagggg auguucgccc agcucgucgc ccagaacgug      300

cugcugaucg acggcccccu cuccugguac agcgacccgg gccuggcggg ggugucccug      360

accggcgggc ucagcuacaa ggaggacacc aaggagcugg ucguggccaa ggccggcgug      420

uacuacgucu ucuuccagcu ggagcuccgg cgcguggugg ccggggaggg cuccggcagc      480

gucucccugg cccugcaccu ccagccccug cggagcgcgg ccggggccgc cgcccuggcg      540

cucacggugg accugccgcc cgccuccagc gaggcccgca acuccgccuu cggcuuccag      600

gggcggcugc uccaccugag cgcgggccag cgccugggcg ugcaccucca caccgaggcc      660

cgggcccgcc acgccuggca gcugacccag ggggccaccg uccugggccu cuuccgggug      720

acgcccgaga uccccgcggg gcugcccagc ccccgcuccg aguga                      765


<210>  3852
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3852
auggaguacg ccuccgacgc cucccucgac cccgaggccc ccuggccccc cgccccccgc       60

gcccgcgccu gccgcguccu ccccugggcc cucgucgccg gccuccuccu ccuccuccuc      120

cucgccgccg ccugcgccgu cuuccucgcc ugccccuggg ccgucuccgg cgcccgcgcc      180

ucccccggcu ccgccgccuc cccccgccuc cgcgagggcc ccgagcucuc ccccgacgac      240

cccgccggcc uccucgaccu ccgccagggc auguucgccc agcucgucgc ccagaacguc      300

cuccucaucg acggcccccu cuccugguac uccgaccccg gccucgccgg cgucucccuc      360

accggcggcc ucuccuacaa ggaggacacc aaggagcucg ucgucgccaa ggccggcguc      420

uacuacgucu ucuuccagcu cgagcuccgc cgcgucgucg ccggcgaggg cuccggcucc      480

gucucccucg cccuccaccu ccagccccuc cgcuccgccg ccggcgccgc cgcccucgcc      540

cucaccgucg accucccccc cgccuccucc gaggcccgca acuccgccuu cggcuuccag      600

ggccgccucc uccaccucuc cgccggccag cgccucggcg uccaccucca caccgaggcc      660

cgcgcccgcc acgccuggca gcucacccag ggcgccaccg uccucggccu cuuccgcguc      720

acccccgaga uccccgccgg ccuccccucc ccccgcuccg aguga                      765


<210>  3853
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3853
auggaguacg ccagcgacgc uucccuggau cccgaagcac cuuggccacc ggcccccaga       60

gcgagggcuu gccgggugcu cccuugggcc cuugucgcag gccuguuguu acugcuacuc      120

cuggccgcug caugugccgu uuuccuugcu ugcccauggg ccgugucugg ggcgcgcgca      180

ucacccggaa gugccgcuag cccucgacug cgugaggguc cagaauuguc ccccgacgau      240

ccugccggcc uccuggaccu gagacagggg auguuugcac aacucguagc ucagaacgug      300

uuacugaucg auggaccacu uucuugguau ucggacccgg gcuuggccgg ugucucacug      360

accgggggac uaagcuacaa ggaggauaca aaagaacucg ugguugcgaa ggccggcgug      420

uauuacgucu ucuuucagcu ggagcuuagg cgggugguag caggcgaggg gaguggaucc      480

guuucucugg cuuugcaccu ccagccccug cgcagcgccg cuggugccgc agccuuagcu      540

cugacugugg accucccucc agcguccuca gaagcaagaa auagugccuu cggcuuucaa      600

gggaggcuuc ugcauuugag cgcuggacag cggcuaggcg uccaucugca cacggaggcc      660

cgcgcacgac acgccuggca gcucacccag ggugcuacag ugcuggggcu uuucagagug      720

acucccgaaa uuccugccgg acugccaucu cccagguccg aguga                      765


<210>  3854
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3854
auggaguacg ccagcgacgc cagccuggac cccgaggccc ccuggccccc cgcccccaga       60

gccagagccu gcagagugcu gcccugggcc cugguggccg gccugcugcu gcugcugcug      120

cuggccgccg ccugcgccgu guuccuggcc ugccccuggg ccgugagcgg cgccagagcc      180

agccccggca gcgccgccag ccccagacug agagagggcc ccgagcugag ccccgacgac      240

cccgccggcc ugcuggaccu gagacagggc auguucgccc agcugguggc ccagaacgug      300

cugcugaucg acggcccccu gagcugguac agcgaccccg gccuggccgg cgugagccug      360

accggcggcc ugagcuacaa ggaggacacc aaggagcugg ugguggccaa ggccggcgug      420

uacuacgugu ucuuccagcu ggagcugaga agaguggugg ccggcgaggg cagcggcagc      480

gugagccugg cccugcaccu gcagccccug agaagcgccg ccggcgccgc cgcccuggcc      540

cugaccgugg accugccccc cgccagcagc gaggccagaa acagcgccuu cggcuuccag      600

ggcagacugc ugcaccugag cgccggccag agacugggcg ugcaccugca caccgaggcc      660

agagccagac acgccuggca gcugacccag ggcgccaccg ugcugggccu guucagagug      720

acccccgaga uccccgccgg ccugcccagc cccagaagcg aguga                      765


<210>  3855
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3855
auggaguacg ccagcgacgc uucccuggau cccgaagccc cuuggccgcc cgcgccuaga       60

gcucgggccu gccgcgugcu ccccugggcc cuggucgcug gccuucugcu ccugcuucug      120

cucgccgcug ccugugcggu uuuccuggcc ugcccuuggg cugugucugg ggccagagcu      180

agccccggau ccgccgcguc uccucggcug cgcgagggcc cggaacucag ccccgacgau      240

ccugccgggc ugcuugaccu gagacaggga auguuugcuc aacucguggc ccagaacguc      300

cugcuuaucg auggcccccu guccugguau ucugacccug ggcucgcugg agugagccug      360

accggcggcc uguccuacaa ggaggauaca aaagaacucg uuguggccaa ggccgggguc      420

uauuacgugu ucuuucagcu ggagcuucgg cgcguugugg cuggagaggg cagcgggucu      480

gucucccugg cgcuccaucu gcagccccuu agaagcgccg cuggagccgc cgcucuggcc      540

cucacggugg accugccgcc ugcgucuucc gaagcucgga auagcgccuu cggcuuucaa      600

gggcgccugc uccaccuguc ugccggacag agacuuggcg ugcaucugca caccgaggcu      660

cgggcccgcc acgcuuggca gcucacacag ggcgccaccg uccuggggcu uuucagaguu      720

acacccgaaa uuccugcggg acugcccagc ccccgguccg aguga                      765


<210>  3856
<211>  765
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       4-1BBL__Homo_sapiens__AAA53134

<400>  3856
auggaauacg caucagaugc aucacuagau ccagaagcac cauggccucc agcuccaaga       60

gcaagagccu guagaguacu accaugggca uuaguugcag gauuauuacu auuauuauua      120

cuagcagcag caugcgcagu auuucuagca uguccauggg cuguuucugg agcuagagca      180

agcccgggcu cagcagcaag cccuagauua agagaaggac cagaauuaag cccagaugau      240

ccagcaggau uacuugauuu aagacaaggu auguuugcac aacuaguagc ucaaaaugua      300

uuacuaauag auggaccacu aaguugguau ucagauccag gauuagcagg aguaagucua      360

acagguggau uaaguuauaa agaagacaca aaagaacuag uagucgcaaa agcgggagua      420

uacuauguau uuuuccaauu agaguuaaga agaguuguag cgggcgaagg aucaggauca      480

guaucauuag cuuuacaucu acaaccacua agaucagccg cuggcgcagc ugcauuagca      540

cucacaguag aucuuccacc agcaaguuca gaagcaagaa auagugcauu cggauuccaa      600

ggaagauuau uacaucuuag cgcgggacaa cgauuaggug uacacuuaca cacagaagca      660

cgagcaagac augcauggca auuaacacaa ggagcaacag uauuaggacu auuuagagua      720

accccagaaa uaccagcagg auuacccuca ccaagaucag aauaa                      765


<210>  3857
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  APRIL__Homo_sapiens__O75888

<400>  3857

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  3858
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  APRIL__Homo_sapiens__AAC61312

<400>  3858
augccagccu caucuccuuu cuugcuagcc cccaaagggc cuccaggcaa cauggggggc       60

ccagucagag agccggcacu cucaguugcc cucugguuga guuggggggc agcucugggg      120

gccguggcuu gugccauggc ucugcugacc caacaaacag agcugcagag ccucaggaga      180

gaggugagcc ggcugcaggg gacaggaggc cccucccaga auggggaagg guaucccugg      240

cagagucucc cggagcagag uuccgaugcc cuggaagccu gggagaaugg ggagagaucc      300

cggaaaagga gagcagugcu cacccaaaaa cagaagaagc agcacucugu ccugcaccug      360

guucccauua acgccaccuc caaggaugac uccgauguga cagaggugau guggcaacca      420

gcucuuaggc gugggagagg ccuacaggcc caaggauaug guguccgaau ccaggaugcu      480

ggaguuuauc ugcuguauag ccagguccug uuucaagacg ugacuuucac caugggucag      540

guggugucuc gagaaggcca aggaaggcag gagacucuau uccgauguau aagaaguaug      600

cccucccacc cggaccgggc cuacaacagc ugcuauagcg caggugucuu ccauuuacac      660

caaggggaua uucugagugu cauaauuccc cgggcaaggg cgaaacuuaa ccucucucca      720

cauggaaccu uccugggguu ugugaaacug uga                                   753


<210>  3859
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       APRIL__Homo_sapiens__AAC61312

<400>  3859
augcccgcca gcuccccguu ccugcucgcc cccaagggcc cgcccgggaa caugggcggg       60

cccgugcgcg agcccgcgcu gagcgucgcc cuguggcucu ccuggggcgc cgcccugggg      120

gccguggcgu gcgccauggc ccugcucacc cagcagaccg agcugcagag ccugcggcgc      180

gagguguccc ggcuccaggg cacgggcggg cccagccaga acggcgaggg guaccccugg      240

cagucccugc cggagcagag cuccgacgcc cuggaggcgu gggagaacgg cgagcgcagc      300

cggaagcgcc gggccguccu cacccagaag cagaagaagc agcacuccgu gcugcaccug      360

gugcccauca acgccaccag caaggacgac uccgacguca ccgaggugau guggcagccc      420

gcccuccgcc gggggcgcgg ccugcaggcc cagggcuacg gggugcggau ccaggacgcg      480

ggcgucuacc ugcucuacag ccaggugcug uuccaggacg ugacguucac cauggggcag      540

gucguguccc gcgagggcca gggccggcag gagacccugu uccgcugcau ccggagcaug      600

cccucccacc cggaccgcgc cuacaacagc ugcuacuccg ccgggguguu ccaccuccac      660

cagggcgaca uccugagcgu caucaucccc cgggcccgcg ccaagcugaa ccucagcccc      720

cacgggaccu uccugggcuu cgugaagcug uga                                   753


<210>  3860
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       APRIL__Homo_sapiens__AAC61312

<400>  3860
augcccgccu ccucccccuu ccuccucgcc cccaagggcc cccccggcaa caugggcggc       60

cccguccgcg agcccgcccu cuccgucgcc cucuggcucu ccuggggcgc cgcccucggc      120

gccgucgccu gcgccauggc ccuccucacc cagcagaccg agcuccaguc ccuccgccgc      180

gaggucuccc gccuccaggg caccggcggc cccucccaga acggcgaggg cuaccccugg      240

cagucccucc ccgagcaguc cuccgacgcc cucgaggccu gggagaacgg cgagcgcucc      300

cgcaagcgcc gcgccguccu cacccagaag cagaagaagc agcacuccgu ccuccaccuc      360

guccccauca acgccaccuc caaggacgac uccgacguca ccgaggucau guggcagccc      420

gcccuccgcc gcggccgcgg ccuccaggcc cagggcuacg gcguccgcau ccaggacgcc      480

ggcgucuacc uccucuacuc ccagguccuc uuccaggacg ucaccuucac caugggccag      540

gucgucuccc gcgagggcca gggccgccag gagacccucu uccgcugcau ccgcuccaug      600

cccucccacc ccgaccgcgc cuacaacucc ugcuacuccg ccggcgucuu ccaccuccac      660

cagggcgaca uccucuccgu caucaucccc cgcgcccgcg ccaagcucaa ccucuccccc      720

cacggcaccu uccucggcuu cgucaagcuc uga                                   753


<210>  3861
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       APRIL__Homo_sapiens__AAC61312

<400>  3861
augcccgcca gcuccccuuu ccugcucgcu ccaaagggcc cgcccgggaa caugggaggu       60

ccugugagag agccagcacu uucugucgcc cugugguugu cauggggcgc ggcuuuaggg      120

gccguugcau gcgccauggc ucugcuaacc cagcaaacag aacuccagag ucugaggcgg      180

gaggugagcc gccuucaggg aacuggcggu cccucccaga auggggaagg auacccuugg      240

caaucucugc cagagcaguc gucagacgca uuggaagccu gggagaacgg cgagcgaagc      300

cguaaaagaa gggcuguacu cacgcagaag cagaaaaagc aacacagugu gcugcaucug      360

guccccauca augccaccuc caaagaugac ucugauguga cagaaguuau guggcagccu      420

gcgcuccggc gcggcagagg guuacaggca cagggauaug gugugaggau ucaagacgcc      480

ggcgucuacc ugcuuuauag ccagguguug uuucaggaug uaacuuucac cauggggcaa      540

guuguguccc gggagggaca gggccgccag gaaacacugu uucgauguau aagaucaaug      600

ccaagucacc cggacagggc uuacaacagc ugcuauucug ccggugucuu ccaucuacac      660

cagggggaua uccucuccgu gauuaucccc cgggcacgug cuaagcugaa ucuuucaccu      720

cauggaaccu uucugggcuu cgugaaguug uga                                   753


<210>  3862
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       APRIL__Homo_sapiens__AAC61312

<400>  3862
augcccgcca gcagccccuu ccugcuggcc cccaagggcc cccccggcaa caugggcggc       60

cccgugagag agcccgcccu gagcguggcc cuguggcuga gcuggggcgc cgcccugggc      120

gccguggccu gcgccauggc ccugcugacc cagcagaccg agcugcagag ccugagaaga      180

gaggugagca gacugcaggg caccggcggc cccagccaga acggcgaggg cuaccccugg      240

cagagccugc ccgagcagag cagcgacgcc cuggaggccu gggagaacgg cgagagaagc      300

agaaagagaa gagccgugcu gacccagaag cagaagaagc agcacagcgu gcugcaccug      360

gugcccauca acgccaccag caaggacgac agcgacguga ccgaggugau guggcagccc      420

gcccugagaa gaggcagagg ccugcaggcc cagggcuacg gcgugagaau ccaggacgcc      480

ggcguguacc ugcuguacag ccaggugcug uuccaggacg ugaccuucac caugggccag      540

guggugagca gagagggcca gggcagacag gagacccugu ucagaugcau cagaagcaug      600

cccagccacc ccgacagagc cuacaacagc ugcuacagcg ccggcguguu ccaccugcac      660

cagggcgaca uccugagcgu gaucaucccc agagccagag ccaagcugaa ccugagcccc      720

cacggcaccu uccugggcuu cgugaagcug uga                                   753


<210>  3863
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       APRIL__Homo_sapiens__AAC61312

<400>  3863
augcccgcca gcuccccuuu ccugcucgcu ccgaaggggc ccccugggaa caugggaggc       60

cccgugagag agccugcccu gucugucgcg cuuuggcuga gcuggggcgc ugcccucgga      120

gccguugcuu gcgccauggc ucugcuuacc cagcaaacag aacugcaguc ccuccggcgc      180

gaggugucua gacugcaggg caccggggga cccagccaga auggcgaagg cuacccuugg      240

caaucccugc cggagcaguc uagcgacgcc cucgaagcgu gggagaacgg ggagcggucc      300

cgcaaaagac gggccgugcu gacgcagaag cagaaaaagc aacacagcgu ccuucaucug      360

gugcccauca augcuacauc uaaagaugac uccgauguua ccgaagugau guggcagccu      420

gcccuccgca gaggacgggg ccugcaggcu cagggguaug gaguccgcau ucaagacgcc      480

ggcguguacc uucuguauag ccagguucuc uuucaggaug ugacauucac cauggggcaa      540

gucgugucua gagagggaca gggccggcag gaaacacugu uucgcuguau cagauccaug      600

cccagccacc cugaccgggc guacaacucu ugcuauuccg ccggcguguu ccaucugcac      660

cagggggaua uucucagcgu caucauuccc cgcgcuagag ccaagcugaa ucuuuccccg      720

cauggaaccu uucugggcuu cguuaagcuc uga                                   753


<210>  3864
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       APRIL__Homo_sapiens__AAC61312

<400>  3864
augccagcau caagcccauu uuuauuagca ccaaaaggac caccaggaaa uaugggagga       60

ccaguaagag aaccagcauu aucaguagca uuaugguuau cguggggagc agcauuagga      120

gcaguagcau gcgcaauggc auuauuaaca caacaaacag aauuacaaag cuuaagaaga      180

gaaguaucaa gauuacaagg aaccggagga ccaagccaaa acggagaagg guaccccugg      240

caaucauuac cagaacaauc aucagaugca uuagaagcau gggaaaaugg agaaagauca      300

agaaaaagaa gagcaguauu aacacaaaaa caaaaaaaac aacauagugu auuacaucuc      360

guaccaauaa augcaacauc aaaagaugau ucagacguaa cagaaguaau guggcaacca      420

gcacuaagaa gaggaagagg auuacaagca caaggguacg gaguaagaau acaagaugca      480

ggaguauauu uauuauauuc acaaguacua uuucaagaug uaacuuucac aaugggacaa      540

guaguaucaa gagaaggaca aggacgacaa gaaacauuau uuagaugcau aagaucaaug      600

ccaucacacc cagacagagc auacaauuca uguuauucag caggaguauu ucacuuacac      660

caaggagaua uauuaagugu aauaauacca agagcaagag caaaauuaaa ucuaucacca      720

cacggaacau ucuuaggauu uguaaaauua uaa                                   753


<210>  3865
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BAFF__Homo_sapiens__Q5H8V1

<400>  3865

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  3866
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BAFF__Homo_sapiens__AAI05124

<400>  3866
augaggcgag ggccccggag ccugcggggc agggacgcgc cagcccccac gcccugcguc       60

ccggccgagu gcuucgaccu gcugguccgc cacugcgugg ccugcgggcu ccugcgcacg      120

ccgcggccga aaccggccgg ggccagcagc ccugcgccca ggacggcgcu gcagccgcag      180

gagucggugg gcgcgggggc cggcgaggcg gcgcugcccc ugcccgggcu gcucuuuggc      240

gcccccgcgc ugcugggccu ggcacugguc cuggcgcugg uccugguggg ucuggugagc      300

uggaggcggc gacagcggcg gcuucgcggc gcguccuccg cagaggcccc cgacggagac      360

aaggacgccc cagagccccu ggacaagguc aucauucugu cuccgggaau cucugaugcc      420

acagcuccug ccuggccucc uccuggggaa gacccaggaa ccaccccacc uggccacagu      480

gucccugugc cagccacaga gcugggcucc acugaacugg ugaccaccaa gacggccggc      540

ccugagcaac aauag                                                       555


<210>  3867
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BAFF__Homo_sapiens__AAI05124

<400>  3867
augcgccggg gcccccgcag ccugcggggg cgcgacgccc cggcccccac ccccugcgug       60

cccgcggagu gcuucgaccu ccugguccgg cacugcgugg ccugcggccu gcuccgcacc      120

ccgcggccca agcccgccgg ggccuccagc cccgccccgc gcacggcgcu gcagccccag      180

gaguccgugg gcgccggggc cggcgaggcc gcgcugcccc uccccggccu gcuguucggg      240

gccccggccc uccugggccu ggcccucguc cuggcccugg ugcucguggg gcuggucagc      300

uggcggcgcc ggcagcgccg gcugcgcggc gcguccagcg ccgaggcccc cgacggggac      360

aaggacgccc ccgagccccu cgacaaggug aucauccugu ccccgggcau cagcgacgcc      420

accgcgcccg ccuggccccc gcccggcgag gaccccggga ccaccccgcc cggccacucc      480

gugcccgucc ccgccacgga gcuggggagc accgagcucg ugaccaccaa gacggccggc      540

cccgagcagc aguga                                                       555


<210>  3868
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BAFF__Homo_sapiens__AAI05124

<400>  3868
augcgccgcg gcccccgcuc ccuccgcggc cgcgacgccc ccgcccccac ccccugcguc       60

cccgccgagu gcuucgaccu ccucguccgc cacugcgucg ccugcggccu ccuccgcacc      120

ccccgcccca agcccgccgg cgccuccucc cccgcccccc gcaccgcccu ccagccccag      180

gaguccgucg gcgccggcgc cggcgaggcc gcccuccccc uccccggccu ccucuucggc      240

gcccccgccc uccucggccu cgcccucguc cucgcccucg uccucgucgg ccucgucucc      300

uggcgccgcc gccagcgccg ccuccgcggc gccuccuccg ccgaggcccc cgacggcgac      360

aaggacgccc ccgagccccu cgacaagguc aucauccucu cccccggcau cuccgacgcc      420

accgcccccg ccuggccccc ccccggcgag gaccccggca ccaccccccc cggccacucc      480

guccccgucc ccgccaccga gcucggcucc accgagcucg ucaccaccaa gaccgccggc      540

cccgagcagc aguga                                                       555


<210>  3869
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BAFF__Homo_sapiens__AAI05124

<400>  3869
augagaaggg gcccccggag ccugcgcggg cgagacgccc cugcuccaac cccgugcgug       60

cccgcagagu guuucgaucu ccuuguccgu cacugcguug ccuguggacu guugagaaca      120

ccuaggccaa agcccgcggg ugcuuccucu ccugccccac ggacugcauu acagccccaa      180

gaaucagugg gcgccggggc uggagaggca gcccugccuc uaccaggccu ccuguuuggu      240

gcuccggccc uucugggguu ggcgcucgua cuggcacugg ugcucgucgg auuagugagu      300

uggcgcagaa ggcagcggcg ccugcgaggc gccagcuccg cugaagcccc cgacggcgau      360

aaagacgcac cugagccacu ugauaagguu aucauuuugu cucccgggau aucggacgcu      420

acggccccug cguggccacc cccgggagaa gauccuggua ccacaccccc aggccauuca      480

gugccugucc ccgccacuga gcuggggagc accgagcuag ugacaaccaa aacugcagga      540

ccagaacagc aguga                                                       555


<210>  3870
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BAFF__Homo_sapiens__AAI05124

<400>  3870
augagaagag gccccagaag ccugagaggc agagacgccc ccgcccccac ccccugcgug       60

cccgccgagu gcuucgaccu gcuggugaga cacugcgugg ccugcggccu gcugagaacc      120

cccagaccca agcccgccgg cgccagcagc cccgccccca gaaccgcccu gcagccccag      180

gagagcgugg gcgccggcgc cggcgaggcc gcccugcccc ugcccggccu gcuguucggc      240

gcccccgccc ugcugggccu ggcccuggug cuggcccugg ugcugguggg ccuggugagc      300

uggagaagaa gacagagaag acugagaggc gccagcagcg ccgaggcccc cgacggcgac      360

aaggacgccc ccgagccccu ggacaaggug aucauccuga gccccggcau cagcgacgcc      420

accgcccccg ccuggccccc ccccggcgag gaccccggca ccaccccccc cggccacagc      480

gugcccgugc ccgccaccga gcugggcagc accgagcugg ugaccaccaa gaccgccggc      540

cccgagcagc aguga                                                       555


<210>  3871
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BAFF__Homo_sapiens__AAI05124

<400>  3871
augagacggg gcccccgcag ccugagaggg cgggacgccc cugcuccgac ccccugcgug       60

ccugccgagu guuucgaucu ccugguccgc cacugcguug cguguggacu ucugagaaca      120

ccccggccua agcccgcugg cgccuccucu ccugccccgc gcacggcucu ccagccccaa      180

gaaagcgugg gggccggagc uggcgaggcc gcgcugccuc uucccgggcu gcucuuugga      240

gccccugcuc ugcugggccu cgcccuggug cuugcucugg uccucguggg ccugguuucc      300

uggagacggc gccagagacg gcuucgcggg gccucuagcg cggaagcccc cgacggagau      360

aaagacgcuc cggagccucu ggauaaggug aucauucucu cccccggcau cucugacgcc      420

accgcuccug ccuggccccc ucccggggaa gauccgggaa caacaccccc uggccauagc      480

guccccgugc cugccaccga gcuggggucc accgagcugg uuacaaccaa aacggcugga      540

cccgaacagc aguga                                                       555


<210>  3872
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       BAFF__Homo_sapiens__AAI05124

<400>  3872
augagaagag gaccaagauc auuaagagga agagaugcac cagcaccaac accaugugua       60

ccagcagaau guuucgaucu auuaguaaga cauuguguag cauguggauu auuaagaaca      120

ccaagaccaa aaccagcagg agcaucauca ccagcaccaa gaacagcauu acaaccacaa      180

gaaucaguag gagcuggagc cggagaagca gcauuaccac uaccaggauu auuauuugga      240

gcacccgcau uauuaggauu agcauuagua cuagcauuag uauuaguugg uuuaguauca      300

uggagaagaa gacaaagaag auuaagagga gcuucaucag cagaagcacc ugauggagau      360

aaagaugcac cagaaccauu agauaaagua auaauauuau caccaggaau aagugaugca      420

acagcaccag cauggccacc accaggagaa gauccaggaa caacaccacc aggccauagc      480

guaccaguac cagcaacaga auuaggauca acagaacuag uaacaacaaa aacagcagga      540

ccagaacaac aauaa                                                       555


<210>  3873
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  BAFF__Homo_sapiens__Q9Y275

<400>  3873

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  3874
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  BAFF__Homo_sapiens__AAD21092

<400>  3874
auggaugacu ccacagaaag ggagcaguca cgccuuacuu cuugccuuaa gaaaagagaa       60

gaaaugaaac ugaaggagug uguuuccauc cucccacgga aggaaagccc cucuguccga      120

uccuccaaag acggaaagcu gcuggcugca accuugcugc uggcacugcu gucuugcugc      180

cucacggugg ugucuuucua ccagguggcc gcccugcaag gggaccuggc cagccuccgg      240

gcagagcugc agggccacca cgcggagaag cugccagcag gagcaggagc ccccaaggcc      300

ggccuggagg aagcuccagc ugucaccgcg ggacugaaaa ucuuugaacc accagcucca      360

ggagaaggca acuccaguca gaacagcaga aauaagcgug ccguucaggg uccagaagaa      420

acagucacuc aagacugcuu gcaacugauu gcagacagug aaacaccaac uauacaaaaa      480

ggaucuuaca cauuuguucc auggcuucuc agcuuuaaaa ggggaagugc ccuagaagaa      540

aaagagaaua aaauauuggu caaagaaacu gguuacuuuu uuauauaugg ucagguuuua      600

uauacugaua agaccuacgc caugggacau cuaauucaga ggaagaaggu ccaugucuuu      660

ggggaugaau ugagucuggu gacuuuguuu cgauguauuc aaaauaugcc ugaaacacua      720

cccaauaauu ccugcuauuc agcuggcauu gcaaaacugg aagaaggaga ugaacuccaa      780

cuugcaauac caagagaaaa ugcacaaaua ucacuggaug gagaugucac auuuuuuggu      840

gcauugaaac ugcuguga                                                    858


<210>  3875
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       BAFF__Homo_sapiens__AAD21092

<400>  3875
auggacgaca gcaccgagcg cgagcagucc cggcugacca gcugccucaa gaagcgcgag       60

gagaugaagc ugaaggagug cguguccauc cugccccgga aggagagccc guccguccgc      120

agcuccaagg acggcaagcu ccuggccgcc acgcugcucc uggcgcugcu cagcugcugc      180

cugaccgugg uguccuucua ccaggucgcc gcccugcagg gggaccucgc cagccugcgg      240

gccgagcugc agggccacca cgcggagaag cuccccgccg gggccggcgc ccccaaggcg      300

gggcuggagg aggcccccgc cgugaccgcc ggccugaaga ucuucgagcc gcccgccccc      360

ggcgagggga acuccagcca gaacucccgc aacaagcggg cggugcaggg ccccgaggag      420

accgucacgc aggacugccu ccagcugauc gccgacagcg agaccccgac cauccagaag      480

ggguccuaca ccuucgugcc cuggcugcuc agcuucaagc gcggcuccgc ccuggaggag      540

aaggagaaca agauccuggu gaaggagacg ggguacuucu ucaucuacgg ccagguccuc      600

uacaccgaca agaccuacgc caugggccac cugauccagc ggaagaaggu gcacguguuc      660

ggggacgagc ugagccucgu cacccuguuc cgcugcaucc agaacaugcc cgagacgcug      720

cccaacaacu ccugcuacag cgccggcauc gcgaagcucg aggaggggga cgagcugcag      780

cuggccaucc cgcgggagaa cgcccagauc agccucgacg gcgacgugac cuucuucggc      840

gcccugaagc ugcucuga                                                    858


<210>  3876
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       BAFF__Homo_sapiens__AAD21092

<400>  3876
auggacgacu ccaccgagcg cgagcagucc cgccucaccu ccugccucaa gaagcgcgag       60

gagaugaagc ucaaggagug cgucuccauc cucccccgca aggagucccc cuccguccgc      120

uccuccaagg acggcaagcu ccucgccgcc acccuccucc ucgcccuccu cuccugcugc      180

cucaccgucg ucuccuucua ccaggucgcc gcccuccagg gcgaccucgc cucccuccgc      240

gccgagcucc agggccacca cgccgagaag cuccccgccg gcgccggcgc ccccaaggcc      300

ggccucgagg aggcccccgc cgucaccgcc ggccucaaga ucuucgagcc ccccgccccc      360

ggcgagggca acuccuccca gaacucccgc aacaagcgcg ccguccaggg ccccgaggag      420

accgucaccc aggacugccu ccagcucauc gccgacuccg agacccccac cauccagaag      480

ggcuccuaca ccuucguccc cuggcuccuc uccuucaagc gcggcuccgc ccucgaggag      540

aaggagaaca agauccucgu caaggagacc ggcuacuucu ucaucuacgg ccagguccuc      600

uacaccgaca agaccuacgc caugggccac cucauccagc gcaagaaggu ccacgucuuc      660

ggcgacgagc ucucccucgu cacccucuuc cgcugcaucc agaacaugcc cgagacccuc      720

cccaacaacu ccugcuacuc cgccggcauc gccaagcucg aggagggcga cgagcuccag      780

cucgccaucc cccgcgagaa cgcccagauc ucccucgacg gcgacgucac cuucuucggc      840

gcccucaagc uccucuga                                                    858


<210>  3877
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       BAFF__Homo_sapiens__AAD21092

<400>  3877
auggacgaua gcaccgagag agaacagucc aggcugacau cuugccucaa gaaacgggag       60

gaaaugaaac uuaaggagug ugugucaauc cugccccgca aggaaagucc uagcguccga      120

uccucuaaag acggcaaguu guuagccgcu acucugcuac ucgcacugcu uucgugcugu      180

cugacgguug ugucauucua ccaaguagcc gcguugcagg gggaucucgc uagccugcgu      240

gccgagcugc agggacacca ugcagagaag cucccagccg gugcuggcgc accgaaagcc      300

ggguuagaag aggcucccgc cgugaccgcg ggacugaaga uuuuugaacc uccagcaccc      360

ggcgagggua acaguuccca aaauucuaga aacaaaaggg ccguccaggg gccugaggaa      420

acagugacuc aggacugccu ucaguugaua gcugauagcg agaccccaac aauccagaag      480

ggauccuaua ccuucguucc cuggcugcua ucauuuaaac ggggcagugc ccucgaagag      540

aaggaaaaua agauucuggu gaaagagacu ggcuacuucu uuaucuaugg gcaaguccuu      600

uacacagaca agaccuaugc aaugggacac cugauucagc gcaaaaaggu gcauguauuc      660

ggugaugagu ugagccucgu uacgcuguuu agauguaucc agaacaugcc ugaaacuuua      720

ccaaauaacu cuugcuacuc cgcuggcaua gccaaacugg aggaagggga cgagcuccag      780

cuugcgaucc cgagggaaaa ugcccaaauu ucacuggaug gagacgugac cuucuuuggc      840

gcauugaagc uacuguga                                                    858


<210>  3878
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       BAFF__Homo_sapiens__AAD21092

<400>  3878
auggacgaca gcaccgagag agagcagagc agacugacca gcugccugaa gaagagagag       60

gagaugaagc ugaaggagug cgugagcauc cugcccagaa aggagagccc cagcgugaga      120

agcagcaagg acggcaagcu gcuggccgcc acccugcugc uggcccugcu gagcugcugc      180

cugaccgugg ugagcuucua ccagguggcc gcccugcagg gcgaccuggc cagccugaga      240

gccgagcugc agggccacca cgccgagaag cugcccgccg gcgccggcgc ccccaaggcc      300

ggccuggagg aggcccccgc cgugaccgcc ggccugaaga ucuucgagcc ccccgccccc      360

ggcgagggca acagcagcca gaacagcaga aacaagagag ccgugcaggg ccccgaggag      420

accgugaccc aggacugccu gcagcugauc gccgacagcg agacccccac cauccagaag      480

ggcagcuaca ccuucgugcc cuggcugcug agcuucaaga gaggcagcgc ccuggaggag      540

aaggagaaca agauccuggu gaaggagacc ggcuacuucu ucaucuacgg ccaggugcug      600

uacaccgaca agaccuacgc caugggccac cugauccaga gaaagaaggu gcacguguuc      660

ggcgacgagc ugagccuggu gacccuguuc agaugcaucc agaacaugcc cgagacccug      720

cccaacaaca gcugcuacag cgccggcauc gccaagcugg aggagggcga cgagcugcag      780

cuggccaucc ccagagagaa cgcccagauc agccuggacg gcgacgugac cuucuucggc      840

gcccugaagc ugcuguga                                                    858


<210>  3879
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       BAFF__Homo_sapiens__AAD21092

<400>  3879
auggacgaua gcaccgagag agaacagucc cggcugacau cuugccucaa gaaacgcgag       60

gaaaugaagc ugaaagagug ugugagcauc cuucccagaa aggaaucccc uucuguccgg      120

agcuccaaag acggcaagcu gcucgccgcu acgcugcuuc uggcccuccu gucuugcugu      180

cugaccguug ugagcuucua ccaaguggcg gcucuccagg gggaucuggc cucccuucgc      240

gccgagcugc agggacacca ugcugagaag cucccggccg gcgcuggggc ccccaaagcg      300

ggacuggaag aggccccugc ugucacagcc ggccuuaaga uuuuugaacc cccugcuccc      360

ggggagggaa acagcucuca aaauuccaga aacaaacggg ccgugcaggg cccugaggaa      420

accguuacac aggacugccu gcagcucauc gcggauagcg agaccccgac aauucagaag      480

ggcucuuaua ccuucgugcc cuggcugcug uccuuuaaac gcgggagcgc ccucgaagag      540

aaggaaaaua agauccuggu caaagagacg ggauacuucu uuauuuaugg ccaagugcuu      600

uacaccgaca agacauaugc uauggggcac cugauccaga gaaagaaggu ucauguguuc      660

ggagaugagc ucucucuggu cacccuuuuu cgguguaucc agaacaugcc ugaaacacug      720

cccaauaacu ccugcuacag cgccggcauu gcuaaacucg aggaagggga cgagcugcag      780

cuggccaucc cucgcgaaaa ugcccaaauu ucccucgaug gagacgugac cuucuuuggc      840

gcucugaaac uucuguga                                                    858


<210>  3880
<211>  858
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       BAFF__Homo_sapiens__AAD21092

<400>  3880
auggacgacu caacagaaag agaacaauca agacuaacaa gcugccuaaa aaaaagagaa       60

gaaaugaaac uaaaagaaug cguaagcaua cuaccaagaa aagaaucucc cucaguaaga      120

ucaucaaaag acggaaaacu acuagcagca acacuacucc uagcacuccu aucaugcugc      180

cuaacuguag uaucauucua ccaaguagca gcacuacaag gagaccuagc aagucuaaga      240

gcagaauuac aaggacacca cgcugaaaaa cucccagcag gagccggagc accaaaagca      300

gguuuagaag aagcaccagc aguaaccgca ggacuaaaaa uauucgaacc accagcacca      360

ggagaaggaa acuccucaca aaacuccaga aauaaaagag caguacaagg accagaagaa      420

acaguaacac aagacugccu acaauuaaua gcagacucag aaacaccaac cauacaaaaa      480

ggaaguuaua cauuuguacc augguuauua ucauucaaaa gaggaagcgc auuagaagaa      540

aaagaaaaca aaauacuagu aaaagaaacc ggauacuucu uuauauacgg ccaaguacua      600

uacacagaca aaacauaugc aaugggacac uuaauacaaa gaaaaaaagu acauguauuc      660

ggcgacgaac uauccuuagu aacacuauuc agaugcauac aaaauaugcc agaaacacua      720

ccaaacaacu cauguuacuc agcaggaaua gccaaacuag aagaagguga cgaacuacaa      780

uuagcaauac caagagaaaa cgcacaaaua ucauuagacg gcgacguaac uuucuuugga      840

gcauuaaaac uauuauaa                                                    858


<210>  3881
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD27L__Homo_sapiens__P32970

<400>  3881

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  3882
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD27L__Homo_sapiens__AAB30121

<400>  3882
augccggagg aggguucggg cugcucggug cggcgcaggc ccuaugggug cguccugcgg       60

gcugcuuugg ucccauuggu cgcgggcuug gugaucugcc ucguggugug cauccagcgc      120

uucgcacagg cucagcagca gcugccgcuc gagucacuug ggugggacgu agcugagcug      180

cagcugaauc acacaggacc ucagcaggac cccaggcuau acuggcaggg gggcccagca      240

cugggccgcu ccuuccugca uggaccagag cuggacaagg ggcagcuacg uauccaucgu      300

gauggcaucu acaugguaca cauccaggug acgcuggcca ucugcuccuc cacgacggcc      360

uccaggcacc accccaccac ccuggccgug ggaaucugcu cucccgccuc ccguagcauc      420

agccugcugc gucucagcuu ccaccaaggu uguaccauug ccucccagcg ccugacgccc      480

cuggcccgag gggacacacu cugcaccaac cucacuggga cacuuuugcc uucccgaaac      540

acugaugaga ccuucuuugg agugcagugg gugcgccccu ga                         582


<210>  3883
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD27L__Homo_sapiens__AAB30121

<400>  3883
augcccgagg agggcagcgg gugcuccgug cgccggcgcc cguacggcug cguccugcgg       60

gccgcccucg ugccccuggu ggcggggcug gucaucugcc ucguggugug cauccagcgc      120

uucgcccagg cccagcagca gcugccccug gagagccucg gcugggacgu cgccgagcug      180

cagcugaacc acaccgggcc ccagcaggac ccgcggcucu acuggcaggg cggccccgcc      240

cuggggcgcu ccuuccugca cggccccgag cucgacaagg ggcagcugcg gauccaccgc      300

gacggcaucu acauggugca cauccaggug acccuggcga ucugcagcuc cacgaccgcc      360

agccggcacc accccaccac ccucgccguc gggaucugcu ccccggccag ccgcuccauc      420

agccugcugc ggcucuccuu ccaccagggc ugcacgaucg cgagccagcg ccugacgccc      480

cuggcccggg gcgacacccu cugcaccaac cugaccggga cccugcuccc cucccgcaac      540

accgacgaga ccuucuucgg cgugcagugg gugcggcccu ga                         582


<210>  3884
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD27L__Homo_sapiens__AAB30121

<400>  3884
augcccgagg agggcuccgg cugcuccguc cgccgccgcc ccuacggcug cguccuccgc       60

gccgcccucg ucccccucgu cgccggccuc gucaucugcc ucgucgucug cauccagcgc      120

uucgcccagg cccagcagca gcucccccuc gagucccucg gcugggacgu cgccgagcuc      180

cagcucaacc acaccggccc ccagcaggac ccccgccucu acuggcaggg cggccccgcc      240

cucggccgcu ccuuccucca cggccccgag cucgacaagg gccagcuccg cauccaccgc      300

gacggcaucu acauggucca cauccagguc acccucgcca ucugcuccuc caccaccgcc      360

ucccgccacc accccaccac ccucgccguc ggcaucugcu cccccgccuc ccgcuccauc      420

ucccuccucc gccucuccuu ccaccagggc ugcaccaucg ccucccagcg ccucaccccc      480

cucgcccgcg gcgacacccu cugcaccaac cucaccggca cccuccuccc cucccgcaac      540

accgacgaga ccuucuucgg cguccagugg guccgccccu ga                         582


<210>  3885
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD27L__Homo_sapiens__AAB30121

<400>  3885
augcccgagg aaggcagcgg gugcuccgug agaaggcggc cuuacggaug uguccugcgc       60

gccgcucucg uuccacuugu ggcaggucug guaaucugcu ugguggucug uauucagcga      120

uucgcccaag cgcagcagca guuaccgcug gagucucuag gcugggacgu ggcugaacuc      180

caacugaacc acaccgggcc ccagcaggau ccucgucuuu auuggcaggg aggcccagcc      240

cuggguagau cauuuuugca ugggcccgag cucgacaagg gacaacugag gauacaccgg      300

gauggcaucu acaugguuca uauucaggug acacuggcaa ucugcaguag cacuacggcc      360

ucccgccacc auccuaccac acucgcuguc ggcauuuguu cuccagcauc gagaucaauc      420

agcuuacuga ggcuuaguuu ccaccagggg ugcacuauag ccucccagcg guugacaccc      480

cuggcucgcg gagacacccu auguaccaau cucacuggua cacugcuucc uucucgaaac      540

accgaugaaa cguuuuucgg cgugcaaugg guaagaccau ga                         582


<210>  3886
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD27L__Homo_sapiens__AAB30121

<400>  3886
augcccgagg agggcagcgg cugcagcgug agaagaagac ccuacggcug cgugcugaga       60

gccgcccugg ugccccuggu ggccggccug gugaucugcc ugguggugug cauccagaga      120

uucgcccagg cccagcagca gcugccccug gagagccugg gcugggacgu ggccgagcug      180

cagcugaacc acaccggccc ccagcaggac cccagacugu acuggcaggg cggccccgcc      240

cugggcagaa gcuuccugca cggccccgag cuggacaagg gccagcugag aauccacaga      300

gacggcaucu acauggugca cauccaggug acccuggcca ucugcagcag caccaccgcc      360

agcagacacc accccaccac ccuggccgug ggcaucugca gccccgccag cagaagcauc      420

agccugcuga gacugagcuu ccaccagggc ugcaccaucg ccagccagag acugaccccc      480

cuggccagag gcgacacccu gugcaccaac cugaccggca cccugcugcc cagcagaaac      540

accgacgaga ccuucuucgg cgugcagugg gugagacccu ga                         582


<210>  3887
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD27L__Homo_sapiens__AAB30121

<400>  3887
augcccgagg aaggcagcgg gugcuccgug agacggcgcc cuuacggaug uguccugaga       60

gccgcucucg uuccgcuggu ggccggccuu gugaucugcc uggucgugug uauucagcgg      120

uucgcgcaag cucagcagca gcucccccug gagucucuug ggugggacgu ugccgaacug      180

caacucaacc acaccggacc ucagcaggau ccccgccugu auuggcaggg cgggccugcc      240

cugggacgga gcuuucucca uggccccgag cuggacaagg gccaacuucg gauccaccgc      300

gaugggauuu acauggugca uauccagguc acacuggcua uuugcuccuc uacgaccgcc      360

agcagacacc auccuacaac ccucgcugug ggaaucuguu ccccggccuc ucggagcauc      420

ucccugcuuc gccugagcuu ccaccagggc ugcacaauug cgucucagag acucacaccc      480

cuggccagag gggacacccu guguaccaau cucacgggaa cccugcuucc uucccgcaac      540

acagaugaaa ccuuuuucgg cguucaaugg gugagacccu ga                         582


<210>  3888
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CD27L__Homo_sapiens__AAB30121

<400>  3888
augccagaag aaggcucagg auguucagua cgaagaagac cauacggaug cguacuaaga       60

gcagcacuag uaccauuagu agcaggacua guaauaugcu uaguaguaug cauacaaaga      120

uucgcacaag cacaacaaca auuaccacua gaaucacuag gaugggacgu agcagaacua      180

caauuaaacc auacaggacc ccaacaagac ccaagacuau acuggcaagg aggaccagca      240

uuaggacgau cauucuuaca cggaccugaa cuagacaaag gacaauuaag aauacacaga      300

gacggaauau acaugguaca cauacaagua acacuagcaa uauguuccag cacaacagca      360

aguagacauc auccaacaac acuagcagua ggcauaugcu caccagcauc aagauccaua      420

aguuuacuaa gacuaucauu ccaucaagga uguacaauag ccagccaacg auuaacacca      480

cuagcaagag gagacacauu auguacaaau uuaacaggaa cauuacuacc aucaagaaau      540

acagacgaaa cauuuuucgg aguacaaugg guaagaccau aa                         582


<210>  3889
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD30L__Homo_sapiens__P32971

<400>  3889

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  3890
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD30L__Homo_sapiens__AAA74594

<400>  3890
auggacccag ggcugcagca agcacucaac ggaauggccc cuccuggaga cacagccaug       60

caugugccgg cgggcuccgu ggccagccac cuggggacca cgagccgcag cuauuucuau      120

uugaccacag ccacucuggc ucugugccuu gucuucacgg uggccacuau uaugguguug      180

gucguucaga ggacggacuc cauucccaac ucaccugaca acgucccccu caaaggagga      240

aauugcucag aagaccucuu auguauccug aaaagagcuc cauucaagaa gucaugggcc      300

uaccuccaag uggcaaagca ucuaaacaaa accaaguugu cuuggaacaa agauggcauu      360

cuccauggag ucagauauca ggaugggaau cuggugaucc aauucccugg uuuguacuuc      420

aucauuugcc aacugcaguu ucuuguacaa ugcccaaaua auucugucga ucugaaguug      480

gagcuucuca ucaacaagca uaucaaaaaa caggcccugg ugacagugug ugagucugga      540

augcaaacga aacacguaua ccagaaucuc ucucaauucu ugcuggauua ccugcagguc      600

aacaccacca uaucagucaa uguggauaca uuccaguaca uagauacaag caccuuuccu      660

cuugagaaug uguuguccau cuucuuauac aguaauucag acuga                      705


<210>  3891
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD30L__Homo_sapiens__AAA74594

<400>  3891
auggaccccg gccugcagca ggcccucaac gggauggccc cgcccggcga caccgcgaug       60

cacgugcccg ccgggagcgu cgccucccac cugggcacca cgagccgcuc cuacuucuac      120

cugaccaccg ccacccucgc ccugugccug guguucacgg uggcgaccau caugguccuc      180

guggugcagc ggaccgacag cauccccaac uccccggaca acgucccccu gaagggcggg      240

aacugcagcg aggaccugcu cugcauccug aagcgcgccc ccuucaagaa guccugggcc      300

uaccuccagg uggccaagca ccugaacaag accaagcuga gcuggaacaa ggacggcauc      360

cugcacgggg ugcgguacca ggacggcaac cucgucaucc aguuccccgg gcuguacuuc      420

aucaucugcc agcugcaguu ccucgugcag ugcccgaaca acuccgugga ccugaagcug      480

gagcuccuga ucaacaagca caucaagaag caggcgcugg ucacggugug cgagagcggc      540

augcagacca agcacgugua ccagaaccuc ucccaguucc ugcuggacua ccuccagguc      600

aacaccacca ucagcgugaa cguggacacg uuccaguaca ucgacaccuc caccuucccc      660

cuggagaacg uccugagcau cuuccucuac uccaacagcg acuga                      705


<210>  3892
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD30L__Homo_sapiens__AAA74594

<400>  3892
auggaccccg gccuccagca ggcccucaac ggcauggccc cccccggcga caccgccaug       60

cacguccccg ccggcuccgu cgccucccac cucggcacca ccucccgcuc cuacuucuac      120

cucaccaccg ccacccucgc ccucugccuc gucuucaccg ucgccaccau caugguccuc      180

gucguccagc gcaccgacuc cauccccaac ucccccgaca acgucccccu caagggcggc      240

aacugcuccg aggaccuccu cugcauccuc aagcgcgccc ccuucaagaa guccugggcc      300

uaccuccagg ucgccaagca ccucaacaag accaagcucu ccuggaacaa ggacggcauc      360

cuccacggcg uccgcuacca ggacggcaac cucgucaucc aguuccccgg ccucuacuuc      420

aucaucugcc agcuccaguu ccucguccag ugccccaaca acuccgucga ccucaagcuc      480

gagcuccuca ucaacaagca caucaagaag caggcccucg ucaccgucug cgaguccggc      540

augcagacca agcacgucua ccagaaccuc ucccaguucc uccucgacua ccuccagguc      600

aacaccacca ucuccgucaa cgucgacacc uuccaguaca ucgacaccuc caccuucccc      660

cucgagaacg uccucuccau cuuccucuac uccaacuccg acuga                      705


<210>  3893
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD30L__Homo_sapiens__AAA74594

<400>  3893
auggaccccg gccugcagca agcccucaac gggauggcuc cuccaggaga uaccgcaaug       60

cacgugccgg ccgguagcgu cgcgucccau cuuggcacaa cuucuagauc auacuucuau      120

cugacgaccg cuacauuggc cuuaugccug guuuuuacug uggcaaccau cauggugcua      180

guaguccaga ggacagacag uauucccaau agcccugaua acgugccacu caaaggggga      240

aauuguuccg aggaccugcu uugcauacug aaacgggccc ccuucaagaa aucuugggcu      300

uacuugcagg uugcaaagca ccucaacaaa accaagcugu cguggaauaa ggauggcauc      360

cugcauggug ugcgcuauca ggacgggaac cucgucauuc aauuuccugg auuauacuuc      420

aucauuuguc agcugcaguu ucuugugcag ugcccaaaua acucaguaga uuugaaacug      480

gaacuacuca ucaauaagca cauaaagaag caagcccugg uuacugugug ugagagcggc      540

augcagacaa aacaugucua ucagaaccuu agucaguucc uguuggacua ccuccaagug      600

aauaccacga ucuccgugaa cgucgauacu uuucaguaua uugacaccuc uacauucccc      660

cuggaaaaug uuuuaagcau cuuucuguac uccaacucag auuga                      705


<210>  3894
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD30L__Homo_sapiens__AAA74594

<400>  3894
auggaccccg gccugcagca ggcccugaac ggcauggccc cccccggcga caccgccaug       60

cacgugcccg ccggcagcgu ggccagccac cugggcacca ccagcagaag cuacuucuac      120

cugaccaccg ccacccuggc ccugugccug guguucaccg uggccaccau cauggugcug      180

guggugcaga gaaccgacag cauccccaac agccccgaca acgugccccu gaagggcggc      240

aacugcagcg aggaccugcu gugcauccug aagagagccc ccuucaagaa gagcugggcc      300

uaccugcagg uggccaagca ccugaacaag accaagcuga gcuggaacaa ggacggcauc      360

cugcacggcg ugagauacca ggacggcaac cuggugaucc aguuccccgg ccuguacuuc      420

aucaucugcc agcugcaguu ccuggugcag ugccccaaca acagcgugga ccugaagcug      480

gagcugcuga ucaacaagca caucaagaag caggcccugg ugaccgugug cgagagcggc      540

augcagacca agcacgugua ccagaaccug agccaguucc ugcuggacua ccugcaggug      600

aacaccacca ucagcgugaa cguggacacc uuccaguaca ucgacaccag caccuucccc      660

cuggagaacg ugcugagcau cuuccuguac agcaacagcg acuga                      705


<210>  3895
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD30L__Homo_sapiens__AAA74594

<400>  3895
auggaccccg gccugcagca agcccucaac gggauggcuc cuccgggaga uaccgccaug       60

cacgugcccg cgggcagcgu cgcuucccau cuggggacaa cgucuagaag cuacuucuau      120

cuuaccacag ccacccuggc ccucugccug guuuuuacag uggcuaccau cauggugcuu      180

gucgugcagc ggacagacuc cauuccuaau ucucccgaua acguuccucu gaagggaggc      240

aauuguagcg aggaccuccu gugcauccug aaacgcgccc ccuucaagaa auccugggcu      300

uaccuccagg uggccaagca ccugaacaaa accaaacuuu cuuggaauaa ggaugggauu      360

cugcauggag ucagauauca ggacggcaac cucgugaucc aauuuccugg ccuguacuuc      420

auuaucuguc agcuucaguu ucugguucag ugcccgaaua acagcgugga ucucaagcug      480

gaacugcuca ucaauaagca cauuaaaaag caagcgcugg ucacggugug ugaguccggg      540

augcagacca aacaugugua ucagaaccuu agccaguucc ugcucgacua ccugcaaguc      600

aauacaacca ucucuguuaa cguggauaca uuucaguaua uugacaccuc cacguucccc      660

cuugaaaaug ugcugagcau cuuucucuac ucuaacuccg auuga                      705


<210>  3896
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CD30L__Homo_sapiens__AAA74594

<400>  3896
auggaccccg gacuccaaca agcacuaaac ggaauggcac caccaggaga cacagcaaug       60

cacguaccag caggaucagu cgcaucacac uuaggaacaa caucuagauc auacuucuac      120

cucacaaccg caacauuagc acuaugccua guauucacag uagcaaccau aaugguacua      180

guaguacaaa gaacagacuc cauacccaac uccccagaua acgucccauu aaaaggagga      240

aacugcucag aagaccuccu cugcauauua aaaagagcac cauucaaaaa aucaugggca      300

uaccuacaag uagcaaaaca cuuaaacaaa accaaacuau cauggaacaa agacggaaua      360

cuacacggag uaagauacca agacggaaac uuaguaauac aauucccagg acuauacuuc      420

auaauauguc aacuacaauu ccuaguacaa ugcccaaaca auucaguaga ccuaaaauua      480

gaacuacuaa ucaacaaaca cauaaaaaaa caagcacuag uaaccguaug cgaaucagga      540

augcaaacca aacacguaua ccaaaaccua ucacaauucc uucucgacua ccuacaagua      600

aacacaacaa uaucaguaaa cguagacaca uuccaauaca uagacacauc uacauuccca      660

cuagaaaacg uacuaucaau cuuccucuac uccaacucag acuaa                      705


<210>  3897
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD40L_(CD154)__Homo_sapiens__P29965

<400>  3897

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  3898
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3898
augaucgaaa cauacaacca aacuucuccc cgaucugcgg ccacuggacu gcccaucagc       60

augaaaauuu uuauguauuu acuuacuguu uuucuuauca cccagaugau ugggucagca      120

cuuuuugcug uguaucuuca uagaagguug gacaagauag aagaugaaag gaaucuucau      180

gaagauuuug uauucaugaa aacgauacag agaugcaaca caggagaaag auccuuaucc      240

uuacugaacu gugaggagau uaaaagccag uuugaaggcu uugugaagga uauaauguua      300

aacaaagagg agacgaagaa agaaaacagc uuugaaaugc aaaaagguga ucagaauccu      360

caaauugcgg cacaugucau aagugaggcc agcaguaaaa caacaucugu guuacagugg      420

gcugaaaaag gauacuacac caugagcaac aacuugguaa cccuggaaaa ugggaaacag      480

cugaccguua aaagacaagg acucuauuau aucuaugccc aagucaccuu cuguuccaau      540

cgggaagcuu cgagucaagc uccauuuaua gccagccucu gccuaaaguc ccccgguaga      600

uucgagagaa ucuuacucag agcugcaaau acccacaguu ccgccaaacc uugcgggcaa      660

caauccauuc acuugggagg aguauuugaa uugcaaccag gugcuucggu guuugucaau      720

gugacugauc caagccaagu gagccauggc acuggcuuca cguccuuugg cuuacucaaa      780

cucuga                                                                 786


<210>  3899
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3899
augaucgaga ccuacaacca gaccagcccc cgcuccgccg ccacgggccu gccgaucagc       60

augaagaucu ucauguaccu ccugaccgug uuccugauca cccagaugau cggguccgcg      120

cuguucgccg ucuaccugca ccggcgccug gacaagaucg aggacgagcg gaaccuccac      180

gaggacuucg uguucaugaa gaccauccag cgcugcaaca cgggcgagcg gagccugucc      240

cugcucaacu gcgaggagau caagagccag uucgaggggu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacucc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgucau cagcgaggcc uccagcaaga ccaccuccgu gcugcagugg      420

gcggagaagg gguacuacac gaugagcaac aaccucguga cccuggagaa cggcaagcag      480

cugaccguca agcgccaggg ccucuacuac aucuacgccc aggugaccuu cugcuccaac      540

cgggaggcca gcucccaggc ccccuucauc gcgagccugu gccugaaguc ccccgggcgc      600

uucgagcgga uccuccugcg cgccgccaac acgcacagcu ccgccaagcc gugcggccag      660

cagagcaucc accucggggg cguguucgag cuccagcccg gggccagcgu cuucgugaac      720

gugaccgacc ccucccaggu cagccacggc accggcuuca ccuccuucgg gcugcugaag      780

cucuga                                                                 786


<210>  3900
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3900
augaucgaga ccuacaacca gaccuccccc cgcuccgccg ccaccggccu ccccaucucc       60

augaagaucu ucauguaccu ccucaccguc uuccucauca cccagaugau cggcuccgcc      120

cucuucgccg ucuaccucca ccgccgccuc gacaagaucg aggacgagcg caaccuccac      180

gaggacuucg ucuucaugaa gaccauccag cgcugcaaca ccggcgagcg cucccucucc      240

cuccucaacu gcgaggagau caagucccag uucgagggcu ucgucaagga caucaugcuc      300

aacaaggagg agaccaagaa ggagaacucc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgucau cuccgaggcc uccuccaaga ccaccuccgu ccuccagugg      420

gccgagaagg gcuacuacac cauguccaac aaccucguca cccucgagaa cggcaagcag      480

cucaccguca agcgccaggg ccucuacuac aucuacgccc aggucaccuu cugcuccaac      540

cgcgaggccu ccucccaggc ccccuucauc gccucccucu gccucaaguc ccccggccgc      600

uucgagcgca uccuccuccg cgccgccaac acccacuccu ccgccaagcc cugcggccag      660

caguccaucc accucggcgg cgucuucgag cuccagcccg gcgccuccgu cuucgucaac      720

gucaccgacc ccucccaggu cucccacggc accggcuuca ccuccuucgg ccuccucaag      780

cucuga                                                                 786


<210>  3901
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3901
augaucgaga ccuacaacca gacaagcccc agauccgccg cuacuggccu gccuauuucu       60

augaagauau ucauguaucu ccuuacggug uuucugauca cccaaaugau ugggucagca      120

uuguucgccg ucuacuuaca caggcggcug gacaaaaucg aagaugagcg caaucuacau      180

gaagacuuug uuuucaugaa gacaauucag cgaugcaaca cuggagagcg uagucucagc      240

cugcuuaauu gugaagagau caaaucccag uuugaggguu ucgugaagga uauaaugcug      300

aacaaagaag agaccaagaa ggaaaauucu uuugagaugc agaaaggcga ccaaaaccca      360

cagaucgcgg cucacguaau uucggaggcc ucaagcaaga caaccagugu guugcagugg      420

gcagaaaaag gguauuacac uauguccaau aaccucguca cacuggagaa uggaaagcag      480

cugaccguga aaagacaagg ccucuauuac aucuaugccc agguuacguu cugcucuaac      540

agggaagcua gcucccaggc accguuuauu gccucauuau gucugaagag ucccggucgg      600

uucgagcgca uccuuuugag agcugccaau acucauagcu cugcgaagcc uugcgggcag      660

caauccauac accugggagg cguguuugaa cuacagccag gcgcaucagu cuucgugaac      720

guaaccgauc ccagccaggu uagucauggg acaggauuua cuucuuucgg ucuccugaaa      780

cuuuga                                                                 786


<210>  3902
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3902
augaucgaga ccuacaacca gaccagcccc agaagcgccg ccaccggccu gcccaucagc       60

augaagaucu ucauguaccu gcugaccgug uuccugauca cccagaugau cggcagcgcc      120

cuguucgccg uguaccugca cagaagacug gacaagaucg aggacgagag aaaccugcac      180

gaggacuucg uguucaugaa gaccauccag agaugcaaca ccggcgagag aagccugagc      240

cugcugaacu gcgaggagau caagagccag uucgagggcu ucgugaagga caucaugcug      300

aacaaggagg agaccaagaa ggagaacagc uucgagaugc agaagggcga ccagaacccc      360

cagaucgccg cccacgugau cagcgaggcc agcagcaaga ccaccagcgu gcugcagugg      420

gccgagaagg gcuacuacac caugagcaac aaccugguga cccuggagaa cggcaagcag      480

cugaccguga agagacaggg ccuguacuac aucuacgccc aggugaccuu cugcagcaac      540

agagaggcca gcagccaggc ccccuucauc gccagccugu gccugaagag ccccggcaga      600

uucgagagaa uccugcugag agccgccaac acccacagca gcgccaagcc cugcggccag      660

cagagcaucc accugggcgg cguguucgag cugcagcccg gcgccagcgu guucgugaac      720

gugaccgacc ccagccaggu gagccacggc accggcuuca ccagcuucgg ccugcugaag      780

cuguga                                                                 786


<210>  3903
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3903
augaucgaga ccuacaacca gacaagcccc agauccgccg cuacgggccu gccuauuucu       60

augaagaucu ucauguaucu ccugaccgug uuucuuauua cacaaaugau cgggagcgcc      120

cuguucgcgg ucuaccucca ccggcgccug gacaaaauug aagaugagag aaaucuucau      180

gaagacuuug uuuucaugaa gaccauccag cggugcaaca caggagagcg cucccugucu      240

cuccugaauu gugaagagau caaaagccag uuugagggcu ucgugaagga uauuaugcug      300

aacaaagaag agaccaagaa ggaaaauucc uuugagaugc agaaagggga ccaaaacccg      360

cagaucgcug cccacgugau uucugaggcc agcuccaaga caaccagcgu ccuccagugg      420

gcugaaaaag gauauuacac gaugucuaau aaccugguga cccuugagaa uggcaagcag      480

cugacaguua aaagacaagg gcucuauuac aucuaugccc aggugaccuu cugcuccaac      540

cgggaagcua gcucucaggc ccccuuuauu gcgucccugu gucuuaagag cccuggacgc      600

uucgagagaa uccugcuccg ggccgcuaau acacauucuu ccgccaagcc cugcggccag      660

caaagcauuc accugggcgg ggucuuugaa cugcagccug gagcuuccgu guucguuaac      720

gugaccgauc ccucucaggu cagccauggc acgggguuua cauccuucgg acuccugaaa      780

cuuuga                                                                 786


<210>  3904
<211>  786
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CD40L_(CD154)__Homo_sapiens__AAA35662

<400>  3904
augauagaaa cauauaauca aacaagccca agaucagcag caacaggacu accaauauca       60

augaaaauau ucauguaccu acucacaguc uuccuaauaa cacaaaugau aggaucugcc      120

cuauuugcag uauaccuaca cagaagacua gauaaaauag aagacgaaag aaaccuacau      180

gaagacuucg uauucaugaa aacaauacaa agaugcaaca ccggagaaag aucccuauca      240

cuacuaaacu gcgaagaaau aaaaucacaa uucgaaggau ucguaaaaga cauaaugcua      300

aacaaagaag aaacaaaaaa agaaaacucu uucgaaaugc aaaaaggaga ccaaaaccca      360

caaauagcug cacacgucau aucagaagca ucaucaaaaa caacaucagu acuucaaugg      420

gcagaaaaag gauacuauac aaugucaaac aaucuaguaa cccuagaaaa cggaaaacaa      480

cuaacaguaa aaagacaagg acuauacuau auauacgcac aaguaacauu cugcucaaac      540

agagaagcau caucacaagc accauucauc gcaucacuau gccuaaaauc cccaggaaga      600

uucgaacgaa uccuacuaag agcagcaaac acacacucau cagcaaaacc augcggccaa      660

caaucaauac accuaggagg aguauucgaa cuacaaccag gagcaucagu auucguaaac      720

guaacagacc ccucacaagu aagccacggc acaggauuca caucauuugg acuauuaaaa      780

uuauaa                                                                 786


<210>  3905
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  EL-17C__Homo_sapiens__Q9P0M4

<400>  3905

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  3906
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  EL-17C__Homo_sapiens__AAF28105

<400>  3906
augacgcucc uccccggccu ccuguuucug accuggcugc acacaugccu ggcccaccau       60

gaccccuccc ucagggggca cccccacagu cacgguaccc cacacugcua cucggcugag      120

gaacugcccc ucggccaggc ccccccacac cugcuggcuc gaggugccaa gugggggcag      180

gcuuugccug uagcccuggu guccagccug gaggcagcaa gccacagggg gaggcacgag      240

aggcccucag cuacgaccca gugcccggug cugcggccgg aggagguguu ggaggcagac      300

acccaccagc gcuccaucuc acccuggaga uaccgugugg acacggauga ggaccgcuau      360

ccacagaagc uggccuucgc cgagugccug ugcagaggcu guaucgaugc acggacgggc      420

cgcgagacag cugcgcucaa cuccgugcgg cugcuccaga gccugcuggu gcugcgccgc      480

cggcccugcu cccgcgacgg cucggggcuc cccacaccug gggccuuugc cuuccacacc      540

gaguucaucc acguccccgu cggcugcacc ugcgugcugc cccguucagu guga            594


<210>  3907
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3907
augacccugc uccccggccu gcuguuccuc accuggcugc acacgugccu ggcccaccac       60

gacccgagcc uccgcgggca cccccacucc cacggcacgc cccacugcua cagcgccgag      120

gagcugcccc uggggcaggc gccgccccac cuccuggccc ggggcgccaa gugggggcag      180

gcccugcccg uggcccucgu cuccagccug gaggcggccu cccaccgcgg ccggcacgag      240

cgccccagcg ccaccaccca gugcccggug cugcggcccg aggaggugcu cgaggccgac      300

acccaccagc gcuccaucag ccccuggcgg uaccgcgucg acaccgacga ggaccgguac      360

ccccagaagc uggcguucgc cgagugccug ugccgcggcu gcaucgacgc ccggaccggg      420

cgcgagaccg ccgcccucaa cuccgugcgg cugcugcaga gccuccuggu gcugcgccgg      480

cgcccgugcu cccgggacgg cagcgggcuc cccacccccg gcgcguucgc cuuccacacc      540

gaguucaucc acguccccgu ggggugcacg ugcgugcugc cgcgcuccgu cuga            594


<210>  3908
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3908
augacccucc uccccggccu ccucuuccuc accuggcucc acaccugccu cgcccaccac       60

gaccccuccc uccgcggcca cccccacucc cacggcaccc cccacugcua cuccgccgag      120

gagcuccccc ucggccaggc ccccccccac cuccucgccc gcggcgccaa guggggccag      180

gcccuccccg ucgcccucgu cuccucccuc gaggccgccu cccaccgcgg ccgccacgag      240

cgccccuccg ccaccaccca gugccccguc cuccgccccg aggagguccu cgaggccgac      300

acccaccagc gcuccaucuc ccccuggcgc uaccgcgucg acaccgacga ggaccgcuac      360

ccccagaagc ucgccuucgc cgagugccuc ugccgcggcu gcaucgacgc ccgcaccggc      420

cgcgagaccg ccgcccucaa cuccguccgc cuccuccagu cccuccucgu ccuccgccgc      480

cgccccugcu cccgcgacgg cuccggccuc cccacccccg gcgccuucgc cuuccacacc      540

gaguucaucc acguccccgu cggcugcacc ugcguccucc cccgcuccgu cuga            594


<210>  3909
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3909
augacccugc uccccggccu ucuguucuug acaugguuac acacuugccu ggcccaucac       60

gacccuagcc uaagagggca uccacacucc cauggaacgc cgcacuguua cucugcugaa      120

gaacuccccc ugggucaggc accuccacac cuucuggcca ggggcgcgaa gugggggcag      180

gcuuugcccg uggcccucgu cucaagucug gaggcagcca gccaucgggg acgccacgaa      240

cgaccuuccg cuaccacaca augcccaguu cugcgucccg aggaagugcu cgaggcagau      300

acucaucaga gaucuaucuc gccuuggagg uaucggguag acaccgauga ggaccgcuac      360

ccacagaaau uagccuuugc ugaaugucug ugcagaggcu guauugaugc caggacaggu      420

cgggagaccg cggcacuuaa cucagugcgc uugcugcaaa gccuacucgu ccugcgaaga      480

aggccgugca gucgggacgg guccggacuu cccacuccug gcgccuucgc uuuucacaca      540

gaguucauac acgugccagu uggcuguacc ugcgugcugc cccguucugu cuga            594


<210>  3910
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3910
augacccugc ugcccggccu gcuguuccug accuggcugc acaccugccu ggcccaccac       60

gaccccagcc ugagaggcca cccccacagc cacggcaccc cccacugcua cagcgccgag      120

gagcugcccc ugggccaggc ccccccccac cugcuggcca gaggcgccaa guggggccag      180

gcccugcccg uggcccuggu gagcagccug gaggccgcca gccacagagg cagacacgag      240

agacccagcg ccaccaccca gugccccgug cugagacccg aggaggugcu ggaggccgac      300

acccaccaga gaagcaucag ccccuggaga uacagagugg acaccgacga ggacagauac      360

ccccagaagc uggccuucgc cgagugccug ugcagaggcu gcaucgacgc cagaaccggc      420

agagagaccg ccgcccugaa cagcgugaga cugcugcaga gccugcuggu gcugagaaga      480

agacccugca gcagagacgg cagcggccug cccacccccg gcgccuucgc cuuccacacc      540

gaguucaucc acgugcccgu gggcugcacc ugcgugcugc ccagaagcgu guga            594


<210>  3911
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3911
augacccugc uccccggccu gcuuuuccug acauggcucc acacgugccu ggcccaucac       60

gacccuagcc uuagagggca uccgcacucc cauggaacac cccacuguua cucugcugaa      120

gaacugccuc ucggccaggc gcccccucau cugcuggccc gcggggcuaa guggggacaa      180

gcccuccccg uggcccuggu cagcucccuu gaggcugccu cucaccgggg cagacacgaa      240

cggccuagcg cuaccaccca gugcccgguu cugcgccccg aggaagugcu cgaggccgau      300

acacaucaga gauccaucuc uccuuggcgg uaucgcgugg acaccgauga ggacagauac      360

ccccagaaac uggcguuugc cgaaugucuu ugccgggggu guauugaugc ucgcacagga      420

agagagaccg ccgcucugaa cagcguccgg cuccugcaau cccugcucgu gcugcgcaga      480

cggccuugca gccgcgacgg cucuggccuu cccacgccgg gggccuucgc guuucacacc      540

gaguucaucc acguuccugu gggauguaca ugcguccugc ccagauccgu guga            594


<210>  3912
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       EL-17C__Homo_sapiens__AAF28105

<400>  3912
augacauuau uaccaggacu auuauuuuua acaugguuac auacaugucu agcucaucac       60

gauccaucac uaagaggaca uccacauuca cacggaacac cucacuguua uucagcagaa      120

gaauuaccau uaggacaagc accaccacau uuacuagcaa gaggagcaaa auggggacaa      180

gcauuaccag uagcauuagu aagcucacua gaagcagcau cacauagagg aagacaugaa      240

agaccaucag caacaacaca auguccaguc uuaagaccag aagaagucuu agaagcagau      300

acacaucaaa gaucaauauc accauggcga uaccgaguag auacagauga agauagauau      360

ccacaaaaac uagcauuugc agaauguuua uguagaggau guauagaugc aagaacagga      420

agagaaacag cagcauuaaa uuccguaaga uuacuacaaa guuuacuagu auuaagaaga      480

agaccauguu caagagacgg aucaggacua ccaacuccag gagcauucgc cuuucauaca      540

gaauuuauac acguaccagu aggauguacu uguguauuac caagaucagu auaa            594


<210>  3913
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FLT3_ligand__Homo_sapiens__AAA90950.1

<400>  3913

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Val Glu Thr Val Phe His Arg Val Ser Gln Asp Gly Leu Asp Leu Leu 
                165                 170                 175     


Thr Ser 
        


<210>  3914
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FLT3_ligand__Homo_sapiens__U29874.1

<400>  3914
augacagugc uggcgccagc cuggagccca acaaccuauc uccuccugcu gcugcugcug       60

agcucgggac ucagugggac ccaggacugc uccuuccaac acagccccau cuccuccgac      120

uucgcuguca aaauccguga gcugucugac uaccugcuuc aagauuaccc agucaccgug      180

gccuccaacc ugcaggacga ggagcucugc gggggccucu ggcggcuggu ccuggcacag      240

cgcuggaugg agcggcucaa gacugucgcu ggguccaaga ugcaaggcuu gcuggagcgc      300

gugaacacgg agauacacuu ugucaccaaa ugugccuuuc agcccccccc cagcugucuu      360

cgcuucgucc agaccaacau cucccgccuc cugcaggaga ccuccgagca gcugguggcg      420

cugaagcccu ggaucacucg ccagaacuuc ucccggugcc uggagcugca gugucagccc      480

guagagacgg uguuucaccg ugucagccag gauggucucg aucuccugac cucguga         537


<210>  3915
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3915
augaccgugc uggcccccgc cuggagcccg accacguacc uccugcugcu ccugcugcuc       60

uccagcggcc uguccgggac ccaggacugc agcuuccagc acucccccau cagcuccgac      120

uucgcgguca agauccgcga gcugagcgac uaccuccugc aggacuaccc cgugaccgug      180

gccuccaacc ugcaggacga ggagcucugc ggcgggcugu ggcggcuggu ccucgcccag      240

cgcuggaugg agcggcugaa gaccguggcc ggcagcaaga ugcaggggcu gcucgagcgc      300

gugaacacgg agauccacuu cgucaccaag ugcgccuucc agcccccgcc cuccugccug      360

cgguucgugc agaccaacau cagccgccug cuccaggaga ccuccgagca gcugguggcg      420

cugaagcccu ggaucacgcg gcagaacuuc agccgcugcc ucgagcugca gugccagccc      480

gucgagaccg uguuccaccg ggugucccag gacggccugg accuccugac cagcuga         537


<210>  3916
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3916
augaccgucc ucgcccccgc cugguccccc accaccuacc uccuccuccu ccuccuccuc       60

uccuccggcc ucuccggcac ccaggacugc uccuuccagc acucccccau cuccuccgac      120

uucgccguca agauccgcga gcucuccgac uaccuccucc aggacuaccc cgucaccguc      180

gccuccaacc uccaggacga ggagcucugc ggcggccucu ggcgccucgu ccucgcccag      240

cgcuggaugg agcgccucaa gaccgucgcc ggcuccaaga ugcagggccu ccucgagcgc      300

gucaacaccg agauccacuu cgucaccaag ugcgccuucc agcccccccc cuccugccuc      360

cgcuucgucc agaccaacau cucccgccuc cuccaggaga ccuccgagca gcucgucgcc      420

cucaagcccu ggaucacccg ccagaacuuc ucccgcugcc ucgagcucca gugccagccc      480

gucgagaccg ucuuccaccg cgucucccag gacggccucg accuccucac cuccuga         537


<210>  3917
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3917
augaccgugc uggcccccgc uuggagcccu acaacuuacc uccuucuguu guuacugcua       60

uccucuggcc ucucagggac gcaggacugc aguuuccaac acagcccaau cuccucugau      120

uuugcaguca agauuagaga gcugucggac uaucuucugc aggauuaccc gguuaccgug      180

gccucaaacu ugcaggacga ggaacucugu ggaggucugu ggaggcuggu acucgcgcag      240

cgguggaugg aacgcuuaaa aacaguggcu ggcagcaaga ugcaagggcu gcuugagcga      300

gucaauacug aaauacauuu cgugaccaaa ugcgccuuuc agcccccucc aaguuguuug      360

cguuucguuc agacaaacau cuccagacug cuacaggaga ccucugagca acucguggca      420

cugaagcccu ggauuacuag gcagaauuuu agccggugcc uugaacugca gugucagccu      480

gucgagacag uguuccaccg cguaucccaa gauggauugg accuccugac cucauga         537


<210>  3918
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3918
augaccgugc uggcccccgc cuggagcccc accaccuacc ugcugcugcu gcugcugcug       60

agcagcggcc ugagcggcac ccaggacugc agcuuccagc acagccccau cagcagcgac      120

uucgccguga agaucagaga gcugagcgac uaccugcugc aggacuaccc cgugaccgug      180

gccagcaacc ugcaggacga ggagcugugc ggcggccugu ggagacuggu gcuggcccag      240

agauggaugg agagacugaa gaccguggcc ggcagcaaga ugcagggccu gcuggagaga      300

gugaacaccg agauccacuu cgugaccaag ugcgccuucc agcccccccc cagcugccug      360

agauucgugc agaccaacau cagcagacug cugcaggaga ccagcgagca gcugguggcc      420

cugaagcccu ggaucaccag acagaacuuc agcagaugcc uggagcugca gugccagccc      480

guggagaccg uguuccacag agugagccag gacggccugg accugcugac cagcuga         537


<210>  3919
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3919
augaccgugc uggcccccgc uuggagcccu acaacguacc uccugcuucu gcuccugcuu       60

uccucuggcc ugagcgggac ccaggacugc uccuuccaac acucuccgau cagcuccgau      120

uuugccguca agauuagaga gcucucugac uaucugcugc aggauuaccc cguuacagug      180

gcgagcaacc uccaggacga ggaacugugu ggaggccuuu ggcggcuggu gcucgcucag      240

cgcuggaugg aaagacugaa aaccgucgcc ggguccaaga ugcaaggacu ucuggagcgg      300

gugaauacag aaauccauuu cguuaccaaa ugcgccuuuc agccuccccc uagcugucuc      360

cgcuucgugc agacaaacau uucuagacug cugcaggaga ccuccgagca acucgucgcu      420

cugaagcccu ggaucacgcg gcagaauuuu agccgcugcc uugaacugca gugucagccu      480

guggagaccg uuuuccacag agugucucaa gauggccucg accugcuuac auccuga         537


<210>  3920
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       FLT3_ligand__Homo_sapiens__U29874.1

<400>  3920
augacaguac ucgcaccagc auggucacca acaacauacc uacuacuauu acuacuauua       60

uccucaggac uaucaggaac acaagacugc ucauuccaac acucaccaau auccucagac      120

uucgcaguaa aaauacgaga acuaucagac uacuuacuac aagacuaccc aguaacagua      180

gcauccaacc uacaagacga agaacuaugu ggaggacucu ggagauuagu acuagcacaa      240

agauggaugg aaagacuaaa aacaguagca ggcucaaaaa ugcaaggacu acuagaaaga      300

gucaacacag aaauccacuu uguaacaaaa ugcgcauuuc aaccaccccc aucaugccua      360

agauucguac aaacaaacau aucaagauua cuacaagaaa caucagaaca acuaguagca      420

uuaaaaccau ggauaacaag acaaaacuuc ucaagaugcc uagaacucca augccaaccc      480

guagaaacag uauuccacag aguaucacaa gacggauuag accuauuaac cucauaa         537


<210>  3921
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FLT3_ligand__Homo_sapiens__P49771

<400>  3921

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  3922
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3922
augacagugc uggcgccagc cuggagccca acaaccuauc uccuccugcu gcugcugcug       60

agcucgggac ucagugggac ccaggacugc uccuuccaac acagccccau cuccuccgac      120

uucgcuguca aaauccguga gcugucugac uaccugcuuc aagauuaccc agucaccgug      180

gccuccaacc ugcaggacga ggagcucugc gggggccucu ggcggcuggu ccuggcacag      240

cgcuggaugg agcggcucaa gacugucgcu ggguccaaga ugcaaggcuu gcuggagcgc      300

gugaacacgg agauacacuu ugucaccaaa ugugccuuuc agcccccccc cagcugucuu      360

cgcuucgucc agaccaacau cucccgccuc cugcaggaga ccuccgagca gcugguggcg      420

cugaagcccu ggaucacucg ccagaacuuc ucccggugcc uggagcugca gugucagccc      480

gacuccucaa cccugccacc cccauggagu ccccggcccc uggaggccac agccccgaca      540

gccccgcagc ccccucugcu ccuccuacug cugcugcccg ugggccuccu gcugcuggcc      600

gcugccuggu gccugcacug gcagaggacg cggcggagga caccccgccc uggggagcag      660

gugccccccg uccccagucc ccaggaccug cugcuugugg agcacuga                   708


<210>  3923
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3923
augaccgugc uggcccccgc cugguccccg accaccuacc uccugcugcu ccugcugcuc       60

uccagcggcc uguccgggac ccaggacugc agcuuccagc acucccccau cagcuccgac      120

uucgcgguca agauccgcga gcugagcgac uaccuccugc aggacuaccc cgugaccgug      180

gccuccaacc ugcaggacga ggagcucugc ggcgggcugu ggcggcuggu ccucgcccag      240

cgcuggaugg agcggcugaa gaccguggcc ggcagcaaga ugcaggggcu gcucgagcgc      300

gugaacacgg agauccacuu cgucaccaag ugcgccuucc agcccccgcc cuccugccug      360

cgguucgugc agaccaacau cagccgccug cuccaggaga ccuccgagca gcugguggcg      420

cugaagcccu ggaucacgcg gcagaacuuc agccgcugcc ucgagcugca gugccagccc      480

gacuccagca cccugccgcc gcccuggagc ccccggcccc ucgaggccac cgcccccacc      540

gcgccccagc ccccgcugcu gcuccugcug cuccugcccg ucggccugcu ccugcuggcc      600

gccgccuggu gccuccacug gcagcgcacg cggcgccgga cgccccgccc cggcgagcag      660

gucccgcccg ugcccagccc ccaggaccug cugcucgugg agcacuga                   708


<210>  3924
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3924
augaccgucc ucgcccccgc cugguccccc accaccuacc uccuccuccu ccuccuccuc       60

uccuccggcc ucuccggcac ccaggacugc uccuuccagc acucccccau cuccuccgac      120

uucgccguca agauccgcga gcucuccgac uaccuccucc aggacuaccc cgucaccguc      180

gccuccaacc uccaggacga ggagcucugc ggcggccucu ggcgccucgu ccucgcccag      240

cgcuggaugg agcgccucaa gaccgucgcc ggcuccaaga ugcagggccu ccucgagcgc      300

gucaacaccg agauccacuu cgucaccaag ugcgccuucc agcccccccc cuccugccuc      360

cgcuucgucc agaccaacau cucccgccuc cuccaggaga ccuccgagca gcucgucgcc      420

cucaagcccu ggaucacccg ccagaacuuc ucccgcugcc ucgagcucca gugccagccc      480

gacuccucca cccucccccc ccccuggucc ccccgccccc ucgaggccac cgcccccacc      540

gccccccagc ccccccuccu ccuccuccuc cuccuccccg ucggccuccu ccuccucgcc      600

gccgccuggu gccuccacug gcagcgcacc cgccgccgca ccccccgccc cggcgagcag      660

gucccccccg uccccucccc ccaggaccuc cuccucgucg agcacuga                   708


<210>  3925
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3925
augaccgugc uggcccccgc uuggagcccu acaacuuacc uccuucuguu guuacugcua       60

uccucuggcc ucucagggac gcaggacugc aguuuccaac acagcccaau cuccucugau      120

uuugcaguca agauuagaga gcugucggac uaucuucugc aggauuaccc gguuaccgug      180

gccucaaacu ugcaggacga ggaacucugu ggaggucugu ggaggcuggu acucgcgcag      240

cgguggaugg aacgcuuaaa aacaguggcu ggcagcaaga ugcaagggcu gcuugagcga      300

gucaauacug aaauacauuu cgugaccaaa ugcgccuuuc agcccccucc aaguuguuug      360

cguuucguuc agacaaacau cuccagacug cuacaggaga ccucugagca acucguggca      420

cugaagcccu ggauuacuag gcagaauuuu agccggugcc uugaacugca gugucagccu      480

gauuccucaa cauugccacc cccuuggagu ccacgcccgc ucgaggccac cgcucccacg      540

gcaccucaac caccccuguu acugcuccuu cuguugccug ucggacuacu gcuccuggcc      600

gcugccuggu gccuucacug gcagagaacu aggcggcgca ccccacgacc cggcgaacag      660

gugccgccug uacccagccc acaagaccug uugcucguug agcauuga                   708


<210>  3926
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3926
augaccgugc uggcccccgc cuggagcccc accaccuacc ugcugcugcu gcugcugcug       60

agcagcggcc ugagcggcac ccaggacugc agcuuccagc acagccccau cagcagcgac      120

uucgccguga agaucagaga gcugagcgac uaccugcugc aggacuaccc cgugaccgug      180

gccagcaacc ugcaggacga ggagcugugc ggcggccugu ggagacuggu gcuggcccag      240

agauggaugg agagacugaa gaccguggcc ggcagcaaga ugcagggccu gcuggagaga      300

gugaacaccg agauccacuu cgugaccaag ugcgccuucc agcccccccc cagcugccug      360

agauucgugc agaccaacau cagcagacug cugcaggaga ccagcgagca gcugguggcc      420

cugaagcccu ggaucaccag acagaacuuc agcagaugcc uggagcugca gugccagccc      480

gacagcagca cccugccccc ccccuggagc cccagacccc uggaggccac cgcccccacc      540

gccccccagc ccccccugcu gcugcugcug cugcugcccg ugggccugcu gcugcuggcc      600

gccgccuggu gccugcacug gcagagaacc agaagaagaa cccccagacc cggcgagcag      660

gugccccccg ugcccagccc ccaggaccug cugcuggugg agcacuga                   708


<210>  3927
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3927
augaccgugc uggcccccgc uuggagcccu accacguacc uccugcuucu gcuccugcuu       60

uccucuggcc ugagcgggac ccaggacugc uccuuccaac acucuccgau cagcuccgau      120

uuugccguca agauuagaga gcucucugac uaucugcugc aggauuaccc cguuacagug      180

gcgagcaacc uccaggacga ggaacugugu ggaggccuuu ggcggcuggu gcucgcucag      240

cgcuggaugg aaagacugaa aaccgucgcc ggguccaaga ugcaaggacu ucuggagcgg      300

gugaauacag aaauccauuu cguuaccaaa ugcgccuuuc agccuccccc uagcugucuc      360

cgcuucgugc agacaaacau uucuagacug cugcaggaga ccuccgagca acucgucgcu      420

cugaagcccu ggaucacgcg gcagaauuuu agccgcugcc uugaacugca gugucagccu      480

gauucuucca cccucccgcc cccuuggagc cccagaccuc uggaggccac agcucccacc      540

gccccgcaac cuccccuucu gcuccugcug cuccugccug ugggccuucu gcuccuggcg      600

gccgcuuggu gccuucacug gcagcggaca cgcagacgga caccccgccc cggggaacag      660

guuccuccgg ugcccucucc ucaagaccug cuccuggucg agcauuga                   708


<210>  3928
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       FLT3_ligand__Homo_sapiens__CCDS12767.1

<400>  3928
augaccguau uagcaccagc auggucucca acaacauacc uacuacuacu acuauuauua       60

ucuucaggac uaucagguac ccaagacugc ucauuucaac acuccccaau aucaucagac      120

uucgcuguaa aaauaagaga auuaucagac uacuuacuac aagacuaccc aguaacagua      180

gcaucaaacc uacaagauga agaacuaugc ggaggacuau ggcgacucgu auuagcacaa      240

agauggaugg aaagacuaaa aacuguagca ggaucaaaaa ugcaaggacu acuagaacga      300

guaaacacag aaauccacuu cguaaccaaa ugcgcauucc aaccaccacc auccugcuua      360

agauucguac aaacaaacau aucaagacua cuacaagaaa caucagaaca acuaguagca      420

uuaaaaccau ggauaaccag acaaaacuuc uccagaugcu uagaauuaca augccaacca      480

gacucaucca cacuaccacc acccuggucc ccaagacccc uagaagccac agcaccaaca      540

gcaccccaac cacccuuauu auuauuauua cuccuaccag ucggacuacu acuucuagca      600

gcugcauggu gccuacauug gcaaagaacc agaagacgaa caccaagacc aggagaacaa      660

guaccaccag ucccaucacc acaagaccua uuacuaguag aacacuaa                   708


<210>  3929
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  G-CSF__Homo_sapiens__P09919

<400>  3929

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  3930
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  G-CSF__Homo_sapiens__AAK62469

<400>  3930
auggcuggac cugccaccca gagccccaug aagcugaugg cccugcagcu gcugcugugg       60

cacagugcac ucuggacagu gcaggaagcc accccccugg gcccugccag cucccugccc      120

cagagcuucc ugcucaagug cuuagagcaa gugaggaaga uccagggcga uggcgcagcg      180

cuccaggaga agcuggugag ugagugugcc accuacaagc ugugccaccc cgaggagcug      240

gugcugcucg gacacucucu gggcaucccc ugggcucccc ugagcagcug ccccagccag      300

gcccugcagc uggcaggcug cuugagccaa cuccauagcg gccuuuuccu cuaccagggg      360

cuccugcagg cccuggaagg gaucuccccc gaguuggguc ccaccuugga cacacugcag      420

cuggacgucg ccgacuuugc caccaccauc uggcagcaga uggaagaacu gggaauggcc      480

ccugcccugc agcccaccca gggugccaug ccggccuucg ccucugcuuu ccagcgccgg      540

gcaggagggg uccugguugc cucccaucug cagagcuucc uggagguguc guaccgcguu      600

cuacgccacc uugcccagcc cuga                                             624


<210>  3931
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3931
auggccggcc ccgccaccca gagcccgaug aagcugaugg cgcuccagcu gcugcucugg       60

cacuccgccc uguggaccgu gcaggaggcc acgccccugg ggcccgccag cucccucccc      120

cagagcuucc ugcugaagug ccucgagcag guccgcaaga uccagggcga cggggccgcg      180

cugcaggaga agcugguguc cgagugcgcc accuacaagc ucugccaccc ggaggagcug      240

gugcugcucg gccacagccu ggggaucccc ugggcgcccc uguccagcug ccccucccag      300

gcccuccagc uggccggcug ccugagccag cuccacuccg gccuguuccu guaccagggg      360

cuccugcagg cccuggaggg caucagcccg gagcucgggc ccacccugga cacccugcag      420

cucgacgucg ccgacuucgc cacgaccauc uggcagcaga uggaggagcu gggcauggcc      480

cccgcgcugc agcccaccca gggggccaug ccggccuucg ccuccgccuu ccagcggcgc      540

gcgggcggcg ugcucguggc cagccaccuc caguccuucc uggaggucag cuaccgggug      600

cugcgccacc uggcccagcc cuga                                             624


<210>  3932
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3932
auggccggcc ccgccaccca gucccccaug aagcucaugg cccuccagcu ccuccucugg       60

cacuccgccc ucuggaccgu ccaggaggcc accccccucg gccccgccuc cucccucccc      120

caguccuucc uccucaagug ccucgagcag guccgcaaga uccagggcga cggcgccgcc      180

cuccaggaga agcucgucuc cgagugcgcc accuacaagc ucugccaccc cgaggagcuc      240

guccuccucg gccacucccu cggcaucccc ugggcccccc ucuccuccug ccccucccag      300

gcccuccagc ucgccggcug ccucucccag cuccacuccg gccucuuccu cuaccagggc      360

cuccuccagg cccucgaggg caucuccccc gagcucggcc ccacccucga cacccuccag      420

cucgacgucg ccgacuucgc caccaccauc uggcagcaga uggaggagcu cggcauggcc      480

cccgcccucc agcccaccca gggcgccaug cccgccuucg ccuccgccuu ccagcgccgc      540

gccggcggcg uccucgucgc cucccaccuc caguccuucc ucgaggucuc cuaccgcguc      600

cuccgccacc ucgcccagcc cuga                                             624


<210>  3933
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3933
auggccggcc ccgcuaccca gagcccuaug aagcugaugg cacuccaacu ucuguugugg       60

cacuccgccu uauggacagu gcaggaggcg acuccacugg ggccggcuuc uucacuaccc      120

cagaguuucc uccugaaaug ccuugaacag gucagaaaga uccaaggaga cggugccgca      180

cugcaggaga aauugguuag cgaaugugcc acguacaagc ucugccaucc ugaggaacug      240

gugcugcucg gccacuccuu agggauucca ugggcucccc ugucuucgug uccuucacag      300

gcacuucagu uggccggaug ccugagccaa cuacauagug gccucuuucu guaucagggu      360

cuucugcagg cuuuggaggg gauaucccca gagcucggac ccacccugga uacauuacag      420

cuggacguag ccgauuucgc gacuaccauc uggcaacaga uggaggaacu cggcauggcc      480

ccugcacuuc agccaacaca aggcgcuaug ccggccuuug caucugcuuu ccagaggcgg      540

gccgggggag ugcuggucgc gagccacuug caguccuuuc uagaaguguc auaccgcguu      600

cugcgacauc ucgcccagcc cuga                                             624


<210>  3934
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3934
auggccggcc ccgccaccca gagccccaug aagcugaugg cccugcagcu gcugcugugg       60

cacagcgccc uguggaccgu gcaggaggcc accccccugg gccccgccag cagccugccc      120

cagagcuucc ugcugaagug ccuggagcag gugagaaaga uccagggcga cggcgccgcc      180

cugcaggaga agcuggugag cgagugcgcc accuacaagc ugugccaccc cgaggagcug      240

gugcugcugg gccacagccu gggcaucccc ugggcccccc ugagcagcug ccccagccag      300

gcccugcagc uggccggcug ccugagccag cugcacagcg gccuguuccu guaccagggc      360

cugcugcagg cccuggaggg caucagcccc gagcugggcc ccacccugga cacccugcag      420

cuggacgugg ccgacuucgc caccaccauc uggcagcaga uggaggagcu gggcauggcc      480

cccgcccugc agcccaccca gggcgccaug cccgccuucg ccagcgccuu ccagagaaga      540

gccggcggcg ugcugguggc cagccaccug cagagcuucc uggaggugag cuacagagug      600

cugagacacc uggcccagcc cuga                                             624


<210>  3935
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3935
auggccggcc ccgcuaccca gagcccuaug aagcugaugg cccuccaacu gcuucugugg       60

cacuccgcgc ucuggacagu gcaggaggcu acgccgcugg ggcccgccuc uagccuuccu      120

caguccuucc ugcucaaaug ccuggaacag gucagaaaga uccaaggaga cggcgccgcu      180

cugcaggaga aacucguuuc ugaaugugcc accuacaagc ugugccaucc cgaggaacuu      240

gugcugcucg ggcacagccu gggcauuccu ugggcucccc uuuccucuug uccuagccag      300

gcccugcagc ucgcgggaug ccugucccaa cugcauagcg ggcucuuucu guaucaggga      360

cuucugcagg cccucgaggg caucucuccg gagcugggcc ccacacuuga uacccugcag      420

cucgacgugg cugauuucgc cacaaccauu uggcaacaga uggaggaacu ggggauggcu      480

ccugcccugc agcccacaca aggagcgaug ccugccuuug cuuccgccuu ccagcggcgc      540

gcuggcgggg uccucguggc cagccaucug cagucuuuuc uugaaguuuc cuacagagug      600

cugcggcacc ucgcccagcc cuga                                             624


<210>  3936
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       G-CSF__Homo_sapiens__AAK62469

<400>  3936
auggcaggac cagcaacaca aucaccaaug aaauuaaugg cacuacaauu acuauuaugg       60

cacucagcac uauggacagu acaagaagca acaccauuag gaccagcauc cucauuacca      120

caauccuucc uacuaaaaug ccuagaacaa guaagaaaaa uacaaggaga cggagcagca      180

uuacaagaaa aauuaguauc ugaaugcgca acauacaaac uaugucaccc agaagaacuc      240

guacuauuag gacauucccu aggaauacca ugggcaccac uaucauccug cccaucacaa      300

gcacuacaau uagcaggaug uuuaucacaa uuacacucag gacuauuccu cuaccaagga      360

cuacuacaag cacuagaagg aauaucccca gaacuaggac caacccuaga cacacuacaa      420

uuagacguag cagacuucgc aacaacaaua uggcaacaaa uggaagaacu aggcauggca      480

ccagcauuac aaccaacaca aggagcaaug ccagcauucg caucagcauu ccaacgaaga      540

gcaggaggag uauuaguagc aucacaccuu caaucauucc uagaaguauc uuaccgagua      600

cuaagacacc uagcacaacc auaa                                             624


<210>  3937
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GITRL__Homo_sapiens__Q9UNG2

<400>  3937

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  3938
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GITRL__Homo_sapiens__CCDS1305.2

<400>  3938
augacauugc auccuucacc caucacuugu gaauuuuugu uuuccacagc ucucauuucu       60

ccaaaaaugu guuugagcca cuuggaaaau augccuuuaa gccauucaag aacucaagga      120

gcucagagau cauccuggaa gcuguggcuc uuuugcucaa uaguuauguu gcuauuucuu      180

ugcuccuuca guuggcuaau cuuuauuuuu cuccaauuag agacugcuaa ggagcccugu      240

auggcuaagu uuggaccauu acccucaaaa uggcaaaugg caucuucuga accuccuugc      300

gugaauaagg ugucugacug gaagcuggag auacuucaga auggcuuaua uuuaauuuau      360

ggccaagugg cucccaaugc aaacuacaau gauguagcuc cuuuugaggu gcggcuguau      420

aaaaacaaag acaugauaca aacucuaaca aacaaaucua aaauccaaaa uguaggaggg      480

acuuaugaau ugcauguugg ggacaccaua gacuugauau ucaacucuga gcaucagguu      540

cuaaaaaaua auacauacug ggguaucauu uuacuagcaa auccccaauu caucuccuag      600


<210>  3939
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3939
augacccugc accccagccc gaucacgugc gaguuccucu ucuccaccgc ccugaucagc       60

cccaagaugu gccuguccca ccucgagaac augccccuga gccacucccg cacccagggc      120

gcccagcgga gcuccuggaa gcuguggcug uucugcagca ucgugaugcu ccuguuccuc      180

ugcuccuuca gcuggcugau cuucaucuuc cugcagcucg agaccgcgaa ggagcccugc      240

auggccaagu ucgggccgcu gcccuccaag uggcagaugg ccagcuccga gccgcccugc      300

gucaacaagg ugagcgacug gaagcuggag auccuccaga acggccugua ccugaucuac      360

gggcaggucg cccccaacgc caacuacaac gacguggcgc ccuucgaggu gcgccucuac      420

aagaacaagg acaugaucca gacccugacg aacaagucca agauccagaa cgugggcggg      480

accuacgagc ugcacgucgg cgacaccauc gaccucaucu ucaacagcga gcaccaggug      540

cugaagaaca acaccuacug gggcaucauc cugcucgcca acccccaguu caucuccuga      600


<210>  3940
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3940
augacccucc accccucccc caucaccugc gaguuccucu ucuccaccgc ccucaucucc       60

cccaagaugu gccucuccca ccucgagaac augccccucu cccacucccg cacccagggc      120

gcccagcgcu ccuccuggaa gcucuggcuc uucugcucca ucgucaugcu ccucuuccuc      180

ugcuccuucu ccuggcucau cuucaucuuc cuccagcucg agaccgccaa ggagcccugc      240

auggccaagu ucggcccccu ccccuccaag uggcagaugg ccuccuccga gccccccugc      300

gucaacaagg ucuccgacug gaagcucgag auccuccaga acggccucua ccucaucuac      360

ggccaggucg cccccaacgc caacuacaac gacgucgccc ccuucgaggu ccgccucuac      420

aagaacaagg acaugaucca gacccucacc aacaagucca agauccagaa cgucggcggc      480

accuacgagc uccacgucgg cgacaccauc gaccucaucu ucaacuccga gcaccagguc      540

cucaagaaca acaccuacug gggcaucauc cuccucgcca acccccaguu caucuccuga      600


<210>  3941
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3941
augacccugc accccagccc uaucacaugc gaguuccucu uuuccacugc ccuuauuucu       60

ccaaagaugu gucugucaca uuuggaaaac augccguuaa gucacagcag aacgcagggc      120

gcucaaaggu ccucuuggaa acuguggcua uucugcucga uagugaugcu ccuguuucuu      180

uguucauuca gcuggcugau cuuuauuuuc uugcagcucg agaccgcaaa ggaacccugc      240

auggccaaau uugggccucu gccaaguaag uggcagaugg cguccucuga gcccccuugu      300

gucaauaaag uuagcgacug gaagcuggaa auccuccaga acggauuaua ccugauuuau      360

ggucaagugg cuccaaaugc caacuacaau gauguagcac ccuucgaggu gcggcuuuau      420

aagaacaaag acaugaucca gacauugacu aauaagucca aaauacagaa cgucggcggg      480

accuacgagc ugcauguggg agauacaauc gaccuaauuu uuaauucaga acaccagguu      540

cucaagaaca auaccuauug gggcaucauu cugcuugcca acccucaauu caucaguuga      600


<210>  3942
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3942
augacccugc accccagccc caucaccugc gaguuccugu ucagcaccgc ccugaucagc       60

cccaagaugu gccugagcca ccuggagaac augccccuga gccacagcag aacccagggc      120

gcccagagaa gcagcuggaa gcuguggcug uucugcagca ucgugaugcu gcuguuccug      180

ugcagcuuca gcuggcugau cuucaucuuc cugcagcugg agaccgccaa ggagcccugc      240

auggccaagu ucggcccccu gcccagcaag uggcagaugg ccagcagcga gccccccugc      300

gugaacaagg ugagcgacug gaagcuggag auccugcaga acggccugua ccugaucuac      360

ggccaggugg cccccaacgc caacuacaac gacguggccc ccuucgaggu gagacuguac      420

aagaacaagg acaugaucca gacccugacc aacaagagca agauccagaa cgugggcggc      480

accuacgagc ugcacguggg cgacaccauc gaccugaucu ucaacagcga gcaccaggug      540

cugaagaaca acaccuacug gggcaucauc cugcuggcca acccccaguu caucagcuga      600


<210>  3943
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3943
augacccugc accccagccc uaucacaugc gaguuccucu uuuccacggc ccugauuucu       60

ccgaagaugu gucuuagcca ucuggaaaac augccccucu cccacucuag aacccagggc      120

gcucaacgga gcuccuggaa acuguggcuu uucugcucua ucgugaugcu gcucuuucug      180

uguagcuucu ccuggcugau uuuuaucuuc cuccagcugg agacagccaa ggaaccuugc      240

auggcgaaau uugggccccu uccuagcaag uggcagaugg cuucuuccga gcccccuugu      300

gucaauaaag uuagcgacug gaagcuggaa auucuccaga acggacugua ccuuaucuau      360

ggccaagugg ccccgaaugc caacuacaau gauguggcuc ccuucgaggu ccgccuguau      420

aagaacaaag acaugaucca gacccucaca aauaagucua aaauucagaa cguuggggga      480

accuacgagc ugcauguggg cgauacaauc gaccugauuu uuaauuccga acaccaggug      540

cucaagaaca auaccuauug ggggaucauu cugcuugcca acccucaauu caucagcuga      600


<210>  3944
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       GITRL__Homo_sapiens__CCDS1305.2

<400>  3944
augacacuac acccaucacc cauaacaugc gaauuccuau ucucaacagc ccuaauauca       60

ccaaaaaugu gccuaucaca ccuagaaaac augccacuau cacacucaag aacacaagga      120

gcacaaagau caucauggaa acucuggcua uucugcucaa ucguaauguu acuauuccua      180

ugcuccuucu cauggcuaau auucauauuc cuccaacuag aaacagcaaa agaaccaugc      240

auggccaaau ucggaccauu accaucuaaa uggcaaaugg caucaucaga acccccaugc      300

guaaacaaag uaucagacug gaaacuagaa auauuacaaa acggacucua uuuaauauac      360

ggacaaguag caccaaacgc aaacuacaac gacguagcac cauucgaagu aagacuauac      420

aaaaauaaag acaugauaca aacacuaaca aacaaaucaa aaauacaaaa cguaggagga      480

acauacgaac uacacguagg agacacaaua gaccuaaucu ucaacucaga acaccaagua      540

cuaaaaaaca acacauacug gggaauaaua cuacuagcaa acccacaauu cauaucauaa      600


<210>  3945
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GM-CSF__Homo_sapiens__P04141

<400>  3945

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 






<210>  3946
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GM-CSF__Homo_sapiens__AAA52122

<400>  3946
auguggcugc agagccugcu gcucuugggc acuguggccu gcagcaucuc ugcacccgcc       60

cgcucgccca gccccagcac acagcccugg gagcauguga augccaucca ggaggcccgg      120

cgucuccuga accugaguag agacacugcu gcugagauga augaaacagu agaagucauc      180

ucagaaaugu uugaccucca ggagccgacc ugccuacaga cccgccugga gcuguacaag      240

cagggccugc ggggcagccu caccaagcuc aagggccccu ugaccaugau ggccagccac      300

uacaaacagc acugcccucc aaccccggaa acuuccugug caacccagau uaucaccuuu      360

gaaaguuuca aagagaaccu gaaggacuuu cugcuuguca uccccuuuga cugcugggag      420

ccaguccagg aguga                                                       435


<210>  3947
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3947
auguggcugc agagccuccu gcugcucggc accguggccu gcuccaucag cgcccccgcg       60

cgcuccccga gccccuccac ccagcccugg gagcacguca acgccaucca ggaggcccgg      120

cgccugcuga accucagccg ggacacggcc gccgagauga acgagaccgu ggaggugauc      180

uccgagaugu ucgaccugca ggagccgacc ugccugcaga cccgccucga gcuguacaag      240

caggggcugc ggggcagccu cacgaagcug aaggggcccc ugaccaugau ggcgucccac      300

uacaagcagc acugcccgcc cacccccgag accagcugcg ccacgcagau caucaccuuc      360

gaguccuuca aggagaaccu caaggacuuc cugcugguca uccccuucga cugcugggag      420

cccgugcagg aguga                                                       435


<210>  3948
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3948
auguggcucc agucccuccu ccuccucggc accgucgccu gcuccaucuc cgcccccgcc       60

cgcucccccu cccccuccac ccagcccugg gagcacguca acgccaucca ggaggcccgc      120

cgccuccuca accucucccg cgacaccgcc gccgagauga acgagaccgu cgaggucauc      180

uccgagaugu ucgaccucca ggagcccacc ugccuccaga cccgccucga gcucuacaag      240

cagggccucc gcggcucccu caccaagcuc aagggccccc ucaccaugau ggccucccac      300

uacaagcagc acugcccccc cacccccgag accuccugcg ccacccagau caucaccuuc      360

gaguccuuca aggagaaccu caaggacuuc cuccucguca uccccuucga cugcugggag      420

cccguccagg aguga                                                       435


<210>  3949
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3949
auguggcugc agagccuccu ucuguugggc accguggccu gcuccaucuc ugcucccgca       60

agaucaccua guccaagcac acaaccgugg gagcacguca acgccauuca ggaagcgagg      120

cgguuacuga aucuaucccg cgacacugcu gccgagauga acgaaacggu ugaggugaua      180

ucugaaaugu ucgaucucca ggagcccacc ugucugcaga cacgacuuga gcuguacaag      240

caaggguugc guggaucgcu cacuaaacug aaggguccuc ugaccaugau ggcaucacau      300

uauaaacagc acugcccacc cacaccugaa accagcugug ccacucagau cauuacauuu      360

gagaguuuca aggaaaaucu caaagacuuu uuacugguaa ucccauucga uugcugggag      420

cccgugcagg aguga                                                       435


<210>  3950
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3950
auguggcugc agagccugcu gcugcugggc accguggccu gcagcaucag cgcccccgcc       60

agaagcccca gccccagcac ccagcccugg gagcacguga acgccaucca ggaggccaga      120

agacugcuga accugagcag agacaccgcc gccgagauga acgagaccgu ggaggugauc      180

agcgagaugu ucgaccugca ggagcccacc ugccugcaga ccagacugga gcuguacaag      240

cagggccuga gaggcagccu gaccaagcug aagggccccc ugaccaugau ggccagccac      300

uacaagcagc acugcccccc cacccccgag accagcugcg ccacccagau caucaccuuc      360

gagagcuuca aggagaaccu gaaggacuuc cugcugguga uccccuucga cugcugggag      420

cccgugcagg aguga                                                       435


<210>  3951
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3951
auguggcugc agagccuccu gcuucugggc accguggccu gcuccaucuc ugcucccgcc       60

agaagcccuu ccccgucuac acaacccugg gagcacguca acgcgauuca ggaagcucgg      120

cgccuccuga aucuuagcag agacacggcc gccgagauga acgaaaccgu ugaggugauc      180

uccgaaaugu ucgaucugca ggagccuaca ugucuccaga cccggcugga gcuguacaag      240

caagggcucc gcggaucucu gacaaaacuu aagggccccc ugaccaugau ggcuagccau      300

uauaaacagc acugcccucc cacaccugaa accuccugug ccacgcagau uaucaccuuu      360

gagagcuuca aggaaaaucu caaagacuuu cugcuuguga uuccguucga uugcugggag      420

cccguccagg aguga                                                       435


<210>  3952
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       GM-CSF__Homo_sapiens__AAA52122

<400>  3952
auguggcucc aaucacuacu acuacuagga acaguagcau gcucaauauc agcaccagca       60

agaucaccau caccaucaac acaaccaugg gaacacguaa acgcaauaca agaagcaaga      120

agacuacuaa acuuaucaag agacacagca gcagaaauga acgaaacagu agaagucaua      180

ucagaaaugu ucgaccuaca agaaccaaca ugccuacaaa caagacuaga acuauacaaa      240

caaggacuaa gaggaucacu aacaaaacua aaaggaccac uaacaaugau ggcaucacac      300

uacaaacaac acugcccacc aacaccagaa acaucaugcg caacacaaau aauaacauuc      360

gaaucauuca aagaaaaccu aaaagacuuc cuacuaguaa uaccauucga cugcugggaa      420

ccaguacaag aauaa                                                       435


<210>  3953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__G9JKF1

<400>  3953

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Pro Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


Gln Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Val Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  3954
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AET86952

<400>  3954
auggccucgc ccuuugcuuu acugaugguc cugguggugc ucagcugcaa gucaagcugc       60

ucuccgggcu gugaucuccc ugagacccac agccuggaua acaggaggac cuugaugcuc      120

cuggcacaaa ugagcagaau cucuccuucc uccugucuga uggacagaca ugacuuugga      180

uuuccccagg aggaguuuga uggcaaccag uuccagaagg cuccagccau cucuguccuc      240

caagagcuga uccagcagau cuucaaccuc uuuaccacaa aagauucauc ugcugcuugg      300

gaugaggacc uccuagacaa auucugcacc gaacucuacc agcagcugaa ugacuuggaa      360

gccuguguga ugcaggagga gaggguggga gaaacucccc ugaugaaugc ggacuccauc      420

uuggcuguga agaaauacuu ccgaagaauc acucucuauc ugacggagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucgugagau cccucucuuu aucaacaaac      540

uugcaagaaa gauuaaggag gaaggaauaa                                       570


<210>  3955
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3955
auggccagcc ccuucgcccu gcucauggug cuggucgugc uguccugcaa gagcuccugc       60

agcccgggcu gcgaccuccc cgagacccac ucccuggaca accgccggac ccugaugcuc      120

cuggcgcaga ugagccgcau cucccccagc uccugccuga uggaccggca cgacuucggg      180

uucccccagg aggaguucga cggcaaccag uuccagaagg ccccggccau cagcgugcuc      240

caggagcuga uccagcagau cuucaaccug uucacgacca aggacuccag cgccgccugg      300

gacgaggacc uccuggacaa guucugcacc gagcuguacc agcagcucaa cgaccuggag      360

gcgugcguca ugcaggagga gcgcgugggg gagacgcccc ugaugaacgc cgacuccauc      420

cucgccguga agaaguacuu ccggcgcauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggaggucgu gcgggcggag aucgugcgcu cccucagccu guccaccaac      540

cugcaggagc ggcuccgccg gaaggaguga                                       570


<210>  3956
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3956
auggccuccc ccuucgcccu ccucaugguc cucgucgucc ucuccugcaa guccuccugc       60

ucccccggcu gcgaccuccc cgagacccac ucccucgaca accgccgcac ccucaugcuc      120

cucgcccaga ugucccgcau cucccccucc uccugccuca uggaccgcca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccccgccau cuccguccuc      240

caggagcuca uccagcagau cuucaaccuc uucaccacca aggacuccuc cgccgccugg      300

gacgaggacc uccucgacaa guucugcacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca ugcaggagga gcgcgucggc gagacccccc ucaugaacgc cgacuccauc      420

cucgccguca agaaguacuu ccgccgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucguccgcu cccucucccu cuccaccaac      540

cuccaggagc gccuccgccg caaggaguga                                       570


<210>  3957
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3957
auggccagcc ccuucgcucu gcucauggug cuugucguuc uguccugcaa gucuucaugu       60

aguccuggcu gcgacuugcc agagacccac agcuuagaua acagaaggac acugaugcua      120

cucgcacaga ugucccggau cucuccgucg ucaugucuga uggaccgcca ugauuuuggg      180

uucccccaag aagaguuuga cggaaaucag uuccagaaag ccccugcgau uagcgugcuu      240

caggaacuga uacaacagau cuuuaacuug uucacuacga aggauaguuc cgcugccugg      300

gacgaggauc uccuggacaa auuuugcacc gaacuguacc agcagcucaa ugauuuagag      360

gcauguguaa ugcaagagga acgagugggu gagacaccac ugaugaacgc cgacucuauu      420

cuugcuguca agaaauauuu ccguagaauc acuuuguacc ugaccgaaaa gaaguauagc      480

cccugcgcau gggagguggu uagggccgag auugugcggu cccuaucacu caguacaaau      540

cugcaggaac gccuuagaag gaaagaguga                                       570


<210>  3958
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3958
auggccagcc ccuucgcccu gcugauggug cugguggugc ugagcugcaa gagcagcugc       60

agccccggcu gcgaccugcc cgagacccac agccuggaca acagaagaac ccugaugcug      120

cuggcccaga ugagcagaau cagccccagc agcugccuga uggacagaca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccccgccau cagcgugcug      240

caggagcuga uccagcagau cuucaaccug uucaccacca aggacagcag cgccgccugg      300

gacgaggacc ugcuggacaa guucugcacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga ugcaggagga gagagugggc gagacccccc ugaugaacgc cgacagcauc      420

cuggccguga agaaguacuu cagaagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucgugagaa gccugagccu gagcaccaac      540

cugcaggaga gacugagaag aaaggaguga                                       570


<210>  3959
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3959
auggccagcc ccuucgcucu gcucauggug cuggucguuc uuuccugcaa gucuagcugu       60

uccccuggcu gcgaccugcc ggagacccac ucucucgaua acagacggac acugaugcuu      120

cuggcccaga ugagccgcau cucccccucu agcugucuca uggacagaca ugauuuuggg      180

uucccucaag aagaguuuga cggaaaucag uuccagaaag cgcccgcuau uuccgugcug      240

caggaacuga uccaacagau uuuuaaccuc uucacgacca aggauagcuc ugccgccugg      300

gacgaggauc ugcuugacaa auuuugcaca gaacuguacc agcagcucaa ugaucuggag      360

gcuuguguga ugcaagagga acgggucggc gagaccccuc uuaugaacgc cgacuccauc      420

cuggcuguga agaaauauuu ccgcagaauu acacucuacc ugaccgaaaa gaaguauagc      480

cccugcgccu gggagguugu gcgggcggag aucguccgcu cucugucccu cagcacaaau      540

cugcaggaaa gacuucggcg caaagaguga                                       570


<210>  3960
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AET86952

<400>  3960
auggcaucac cauucgcauu acuuauggua cuaguaguau uaucuugcaa aucaucaugc       60

uccccaggau gcgaccuacc agaaacacac ucacuagaca acagaagaac auuaaugcua      120

cuagcacaaa ugucacgaau aagcccauca ucaugccuaa uggacagaca cgacuucgga      180

uucccacaag aagaauucga cggaaaccaa uuucaaaaag ccccagcaau aucaguacua      240

caagaacuaa uacaacaaau auucaaccua uucacaacaa aagacagcuc agcagcaugg      300

gacgaagacc uauuagacaa auucugcaca gaacuauacc aacaacuaaa cgaccuagaa      360

gcaugcguaa ugcaagaaga aagaguaggc gaaacaccau uaaugaacgc agacucaaua      420

cuagcaguaa aaaaauacuu uagaagaaua acauuauacu uaacagaaaa aaaauacagc      480

ccaugugccu gggaaguagu aagagcagaa auaguaagau cacuaucacu aucaacaaac      540

uuacaagaaa gauuaagaag aaaagaauaa                                       570


<210>  3961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01562

<400>  3961

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  3962
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAB59403

<400>  3962
auggccucgc ccuuugcuuu acugaugguc cugguggugc ucagcugcaa gucaagcugc       60

ucucugggcu gugaucuccc ugagacccac agccuggaua acaggaggac cuugaugcuc      120

cuggcacaaa ugagcagaau cucuccuucc uccugucuga uggacagaca ugacuuugga      180

uuuccccagg aggaguuuga uggcaaccag uuccagaagg cuccagccau cucuguccuc      240

caugagcuga uccagcagau cuucaaccuc uuuaccacaa aagauucauc ugcugcuugg      300

gaugaggacc uccuagacaa auucugcacc gaacucuacc agcagcugaa ugacuuggaa      360

gccuguguga ugcaggagga gaggguggga gaaacucccc ugaugaaugc ggacuccauc      420

uuggcuguga agaaauacuu ccgaagaauc acucucuauc ugacagagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau cccucucuuu aucaacaaac      540

uugcaagaaa gauuaaggag gaaggaauaa                                       570


<210>  3963
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3963
auggccagcc ccuucgcccu gcucauggug cuggucgugc uguccugcaa gagcuccugc       60

agccucggcu gcgaccugcc ggagacccac ucccuggaca accgccggac ccucaugcug      120

cuggcgcaga ugagccgcau cucccccagc uccugccuca uggaccggca cgacuucggg      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccccgccau cagcgugcug      240

cacgagcuga uccagcagau cuucaaccuc uucacgacca aggacuccag cgccgccugg      300

gacgaggacc ugcuggacaa guucugcacc gagcucuacc agcagcugaa cgaccuggag      360

gcgugcguca ugcaggagga gcgcgugggg gagaccccgc ucaugaacgc cgacuccauc      420

cuggccguga agaaguacuu ccggcgcauc acgcuguacc ucaccgagaa gaaguacagc      480

cccugcgccu gggaggucgu gcgggcggag aucaugcgcu cccugagccu guccaccaac      540

cuccaggagc ggcugcgccg gaaggaguga                                       570


<210>  3964
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3964
auggccuccc ccuucgcccu ccucaugguc cucgucgucc ucuccugcaa guccuccugc       60

ucccucggcu gcgaccuccc cgagacccac ucccucgaca accgccgcac ccucaugcuc      120

cucgcccaga ugucccgcau cucccccucc uccugccuca uggaccgcca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccccgccau cuccguccuc      240

cacgagcuca uccagcagau cuucaaccuc uucaccacca aggacuccuc cgccgccugg      300

gacgaggacc uccucgacaa guucugcacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca ugcaggagga gcgcgucggc gagacccccc ucaugaacgc cgacuccauc      420

cucgccguca agaaguacuu ccgccgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu cccucucccu cuccaccaac      540

cuccaggagc gccuccgccg caaggaguga                                       570


<210>  3965
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3965
auggccagcc ccuucgcucu gcucauggug cuugucguuc uguccugcaa gucuucaugu       60

aguuugggcu gcgacuuacc ugagacccac agccuggaua acagaaggac acuaaugcuc      120

cuggcacaga ugucccggau cucuccaucg ucaugucuua uggaccgcca ugauuuuggg      180

uucccgcaag aagaguuuga cggaaaucag uuccagaaag cccccgcgau uagcgugcug      240

cacgaauuga uacagcaaau cuuuaaccuc uucacuacga aggauaguuc cgcugccugg      300

gacgaggauc ugcuggacaa auuuugcacc gaacucuacc agcaguuaaa ugaucuggag      360

gcauguguaa ugcaggagga acgagugggu gagacaccuc uuaugaacgc cgacucuauu      420

uuggcuguca agaaauauuu ccguagaauc acucuguacc uaaccgaaaa gaaguauagc      480

ccaugcgcau gggagguggu uagggccgag auuaugcggu cccucucacu gaguacaaau      540

cuucaagaac gccugagaag gaaagaguga                                       570


<210>  3966
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3966
auggccagcc ccuucgcccu gcugauggug cugguggugc ugagcugcaa gagcagcugc       60

agccugggcu gcgaccugcc cgagacccac agccuggaca acagaagaac ccugaugcug      120

cuggcccaga ugagcagaau cagccccagc agcugccuga uggacagaca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccccgccau cagcgugcug      240

cacgagcuga uccagcagau cuucaaccug uucaccacca aggacagcag cgccgccugg      300

gacgaggacc ugcuggacaa guucugcacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga ugcaggagga gagagugggc gagacccccc ugaugaacgc cgacagcauc      420

cuggccguga agaaguacuu cagaagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gccugagccu gagcaccaac      540

cugcaggaga gacugagaag aaaggaguga                                       570


<210>  3967
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3967
auggccagcc ccuucgcucu gcucauggug cuggucguuc uuuccugcaa gucuagcugu       60

ucccugggcu gcgaccuccc ugagacccac ucucuggaua acagacggac acuuaugcug      120

cucgcccaga ugagccgcau cuccccgucu agcugucuga uggacagaca ugauuuuggg      180

uucccccaag aagaguuuga cggaaaucag uuccagaaag cgccugcuau uuccgugcug      240

cacgaacuca uccagcaaau uuuuaaccug uucacgacca aggauagcuc ugccgccugg      300

gacgaggauc uucuggacaa auuuugcaca gaacucuacc agcagcugaa ugaucuugag      360

gcuuguguga ugcaggagga acgggucggc gagacacccc ugaugaacgc cgacuccauc      420

cucgcuguga agaaauauuu ccgcagaauu acccuguacc ugaccgaaaa gaaguauagc      480

ccuugcgccu gggagguugu gcgggcggag aucaugcgcu cucucucccu gagcacaaau      540

cuucaagaaa gacugcggcg caaagaguga                                       570


<210>  3968
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAB59403

<400>  3968
auggcaucac cauucgcccu acuaaugguc cuaguaguac uaucaugcaa aucaucaugc       60

ucacuaggau gcgaccuacc agaaacacac ucacuagaua acagaagaac acuaaugcua      120

cuagcacaaa ugucacgaau aucaccaagc ucaugccuaa uggacagaca cgacuucgga      180

uucccacaag aagaauucga uggaaaccaa uuccaaaaag caccagcaau aagcguacua      240

cacgaacuaa uacaacaaau auucaaucua uucacaacaa aagacucauc agcagcaugg      300

gacgaagacc uacuagacaa auucugcaca gaacuauacc aacaauuaaa cgacuuagaa      360

gcaugcguaa ugcaagaaga aagaguagga gaaacaccac uaaugaacgc cgacucaaua      420

cuagcaguaa aaaaauauuu cagaagaauc acauuauacc uaacagaaaa aaaauacuca      480

ccaugcgcau gggaaguagu aagagcagaa auaaugagau cauuaucauu aucaacaaac      540

cuacaagaaa gauuaagacg aaaagaauaa                                       570


<210>  3969
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01563

<400>  3969

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  3970
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA59181

<400>  3970
auggccuuga ccuuugcuuu acugguggcc cuccuggugc ucagcugcaa gucaagcugc       60

ucugugggcu gugaucugcc ucaaacccac agccugggua gcaggaggac cuugaugcuc      120

cuggcacaga ugaggaaaau cucucuuuuc uccugcuuga aggacagaca ugacuuugga      180

uuuccccagg aggaguuugg caaccaguuc caaaaggcug aaaccauccc uguccuccau      240

gagaugaucc agcagaucuu caaucucuuc agcacaaagg acucaucugc ugcuugggau      300

gagacccucc uagacaaauu cuacacugaa cucuaccagc agcugaauga ccuggaagcc      360

ugugugauac aggggguggg ggugacagag acuccccuga ugaaggagga cuccauucug      420

gcugugagga aauacuucca aagaaucacu cucuaucuga aagagaagaa auacagcccu      480

ugugccuggg agguugucag agcagaaauc augagaucuu uuucuuuguc aacaaacuug      540

caagaaaguu uaagaaguaa ggaauga                                          567


<210>  3971
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3971
auggcccuga ccuucgcccu ccugguggcg cugcucgucc ugagcugcaa guccagcugc       60

uccgugggcu gcgaccugcc ccagacccac agccucgggu cccgccggac gcugaugcug      120

cucgcccaga ugcgcaagau cagccuguuc uccugccuga aggaccggca cgacuucggc      180

uucccgcagg aggaguucgg gaaccaguuc cagaaggccg agaccauccc cgugcuccac      240

gagaugaucc agcagaucuu caaccuguuc agcaccaagg acuccagcgc cgccugggac      300

gagacccugc ucgacaaguu cuacacggag cuguaccagc agcugaacga ccucgaggcg      360

ugcgucaucc agggcguggg ggugaccgag acgccccuga ugaaggagga cuccauccug      420

gccguccgca aguacuucca gcggaucacc cucuaccuga aggagaagaa guacagcccc      480

ugcgccuggg agguggugcg cgccgagauc augcgguccu ucagccuguc caccaaccuc      540

caggagagcc ugcgcuccaa ggaguga                                          567


<210>  3972
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3972
auggcccuca ccuucgcccu ccucgucgcc cuccucgucc ucuccugcaa guccuccugc       60

uccgucggcu gcgaccuccc ccagacccac ucccucggcu cccgccgcac ccucaugcuc      120

cucgcccaga ugcgcaagau cucccucuuc uccugccuca aggaccgcca cgacuucggc      180

uucccccagg aggaguucgg caaccaguuc cagaaggccg agaccauccc cguccuccac      240

gagaugaucc agcagaucuu caaccucuuc uccaccaagg acuccuccgc cgccugggac      300

gagacccucc ucgacaaguu cuacaccgag cucuaccagc agcucaacga ccucgaggcc      360

ugcgucaucc agggcgucgg cgucaccgag accccccuca ugaaggagga cuccauccuc      420

gccguccgca aguacuucca gcgcaucacc cucuaccuca aggagaagaa guacuccccc      480

ugcgccuggg aggucguccg cgccgagauc augcgcuccu ucucccucuc caccaaccuc      540

caggaguccc uccgcuccaa ggaguga                                          567


<210>  3973
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3973
auggcccuga ccuucgcucu ccuuguggca cuguuggucu uaagcugcaa guccucuugu       60

ucaguuggcu gcgaccugcc ccagacacac agucuaggga gcagaaggac ucucaugcug      120

cuugcccaaa ugcggaaaau cucccuguuu ucuuguuuga aggaucgcca ugacuucgga      180

uuuccucagg aggaguucgg uaaccaguuu cagaaagcgg aaacgauucc agugcuccac      240

gaaaugauac aacagaucuu caaucuguuu ucgaccaagg auucaagcgc ugccugggac      300

gagacacugc ucgauaaauu cuacacugaa uuauaucagc agcugaacga ccuugaggca      360

ugcguaauuc aaggcguggg ggucaccgag acaccguuga ugaaggaaga uaguauccug      420

gccgugcgaa aguacuuuca gcguauuacc cuauaucuca aagagaagaa auacuccccc      480

ugugcuuggg aaguugugag agcagagauc augaggucuu ucagccuguc cacuaaucuu      540

caggagucac ugcggaguaa ggaauga                                          567


<210>  3974
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3974
auggcccuga ccuucgcccu gcugguggcc cugcuggugc ugagcugcaa gagcagcugc       60

agcgugggcu gcgaccugcc ccagacccac agccugggca gcagaagaac ccugaugcug      120

cuggcccaga ugagaaagau cagccuguuc agcugccuga aggacagaca cgacuucggc      180

uucccccagg aggaguucgg caaccaguuc cagaaggccg agaccauccc cgugcugcac      240

gagaugaucc agcagaucuu caaccuguuc agcaccaagg acagcagcgc cgccugggac      300

gagacccugc uggacaaguu cuacaccgag cuguaccagc agcugaacga ccuggaggcc      360

ugcgugaucc agggcguggg cgugaccgag accccccuga ugaaggagga cagcauccug      420

gccgugagaa aguacuucca gagaaucacc cuguaccuga aggagaagaa guacagcccc      480

ugcgccuggg agguggugag agccgagauc augagaagcu ucagccugag caccaaccug      540

caggagagcc ugagaagcaa ggaguga                                          567


<210>  3975
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3975
auggcccuga ccuucgcucu ccugguggcc cuucuggucc ucagcugcaa guccucuugu       60

agcguuggcu gcgaccugcc ccagacacac ucccuugggu cuagacggac gcugaugcuc      120

cuggcgcaaa ugcgcaaaau cagccuguuu uccugucuca aggauagaca ugacuucgga      180

uuuccucagg aggaauuugg caaccaguuu cagaaagcug agaccauucc ggugcugcac      240

gaaaugaucc aacagauuuu caaucuuuuc ucuacaaagg auagcuccgc cgccugggac      300

gagacccugc ucgauaaauu cuacacagaa cuguaucagc agcuuaacga ccuggaggcu      360

ugcgugaucc aaggggucgg agugaccgag acaccccuca ugaaggaaga uagcauucug      420

gccguucgga aguacuuuca gcgcaucacc cuguaucuca aagagaagaa auacucuccu      480

ugugcuuggg aaguggucag agccgagauc augcgguccu ucagccuguc uacgaaucuu      540

caggaguccc ugcgcagcaa ggaauga                                          567


<210>  3976
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA59181

<400>  3976
auggcacuaa cauucgcacu acuaguagca uuacuaguau uaucaugcaa aucaucaugc       60

ucaguaggau gcgaccuacc acaaacacac ucauuaggau caagaagaac acuaaugcua      120

cuagcacaaa ugagaaaaau aucacuauuc ucaugccuaa aagacagaca cgacuucgga      180

uucccacaag aagaauucgg aaaccaauuc caaaaagcag aaacaauacc aguacuacac      240

gaaaugauac aacaaauauu caacuuauuc ucaacaaaag acucaucagc agcaugggac      300

gaaacccuac uagacaaauu cuacacagaa cuauaccaac aacuaaacga ccuagaagca      360

ugcguaauac aaggaguagg agucacagaa acaccacuaa ugaaagaaga cucaauacua      420

gcaguaagaa aauacuucca acgaauaaca cuauaccuaa aagaaaaaaa auacucccca      480

ugcgcauggg aaguaguaag agcagaaaua augagauccu ucucacuauc caccaaccua      540

caagaauccc uaagaucaaa agaauaa                                          567


<210>  3977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01566

<400>  3977

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  3978
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAH69409

<400>  3978
auggcccugu ccuuuucuuu acuuauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucuaggcu gugaucugcc ucagacccac agccugggua auaggagggc cuugauacuc      120

cugggacaaa ugggaagaau cucuccuuuc uccugccuga aggacagaca ugauuuccga      180

aucccccagg aggaguuuga uggcaaccag uuccagaagg cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacag aggacucauc ugcugcuugg      300

gaacagagcc uccuagaaaa auuuuccacu gaacuuuacc agcaacugaa ugaccuggaa      360

gcauguguga uacaggaggu ugggguggaa gagacucccc ugaugaauga ggacuccauc      420

cuggcuguga ggaaauacuu ccaaagaauc acucuuuauc uaauagagag gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau cccucucguu uucaacaaac      540

uugcaaaaaa gauuaaggag gaaggauuga                                       570


<210>  3979
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3979
auggcccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc ccagacccac ucccucggga accgccgggc gcugauccug      120

cucggccaga uggggcgcau cagcccguuc uccugccuga aggaccggca cgacuuccgc      180

aucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccuc uucuccacgg aggacagcuc cgccgccugg      300

gagcagagcc ugcuggagaa guucuccacc gagcucuacc agcagcugaa cgaccuggag      360

gcgugcguga uccaggaggu cgggguggag gagacgcccc ucaugaacga ggacagcauc      420

cuggccgugc ggaaguacuu ccagcgcauc acccuguacc ucaucgagcg gaaguacucc      480

cccugcgccu gggaggucgu gcgcgccgag aucaugcgga gccuguccuu cagcaccaac      540

cugcagaagc gccuccggcg caaggacuga                                       570


<210>  3980
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3980
auggcccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucggccaga ugggccgcau cucccccuuc uccugccuca aggaccgcca cgacuuccgc      180

aucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccaccg aggacuccuc cgccgccugg      300

gagcaguccc uccucgagaa guucuccacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca uccaggaggu cggcgucgag gagacccccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaucgagcg caaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu cccucuccuu cuccaccaac      540

cuccagaagc gccuccgccg caaggacuga                                       570


<210>  3981
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3981
auggcccuga gcuucucccu ccuuauggcu gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ccagacccac agccuaggga acagaagggc acucauucug      120

cuuggacaaa ugggucggau auccccuuuu ucuugccuga aagaucgcca ugacuuccga      180

aucccacagg aggaauuuga uggcaaucag uuccagaagg cccaagcgau uucgguuuug      240

cacgagauga uccagcagac auuuaaccuc uucucaacug aagacagcag ugcugccugg      300

gagcaguccc ugcuggaaaa auuuucuacg gagcucuauc aacaguuaaa ugaucuggag      360

gcauguguga uucaggaagu agggguggag gaaaccccgc uuaugaacga ggacagcauc      420

uuggccgucc guaaguacuu ccagagaaua acacuguauc uaaucgagag gaaauacucc      480

cccugcgcuu gggaaguggu ucgggcagag auuaugcgcu cacucaguuu uagcacuaau      540

cugcaaaaga gacuuaggcg gaaggauuga                                       570


<210>  3982
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3982
auggcccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cugggccaga ugggcagaau cagccccuuc agcugccuga aggacagaca cgacuucaga      180

aucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcaccg aggacagcag cgccgccugg      300

gagcagagcc ugcuggagaa guucagcacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga uccaggaggu gggcguggag gagacccccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaucgagag aaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gccugagcuu cagcaccaac      540

cugcagaaga gacugagaag aaaggacuga                                       570


<210>  3983
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3983
auggcccuga gcuucucccu ccugauggcu gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ccagacccac ucucuuggga acagacgggc ccugauucuc      120

cugggacaaa ugggccgcau cagcccuuuu uccugccuga aagauagaca ugacuuccgg      180

auuccgcagg aggaauuuga ugggaaucag uuccagaagg cgcaagcuau cucuguucuc      240

cacgagauga uucagcagac auuuaaccug uucagcacgg aagacuccag cgccgccugg      300

gagcagucuc uucuggaaaa auuuuccacc gagcucuauc aacagcugaa ugaucuugag      360

gcuuguguga uccaggaagu gggagucgag gaaacacccc ugaugaacga ggacagcauc      420

cucgccgugc gcaaguacuu ccagagaauu acccuguauc ugaucgagcg gaaauacucu      480

ccuugcgcuu gggaaguugu gcgcgccgag auuaugagau cccucagcuu uucuacaaau      540

cugcaaaagc ggcuucgcag aaaggauuga                                       570


<210>  3984
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAH69409

<400>  3984
auggcacuau cauucucacu acuaauggca guacuaguac uaucauacaa auccauaugc       60

ucacucggau gcgaccuacc acaaacacac ucacuaggaa acagaagagc auuaauacua      120

cuaggacaaa ugggaagaau aucaccauuc ucaugccuaa aagacagaca cgacuucaga      180

auaccacaag aagaauucga cggaaaccaa uuccaaaaag cacaagccau auccguacua      240

cacgaaauga uacaacaaac auucaacuua uucucaacag aagacagcuc agcagcaugg      300

gaacaaucac uacuagaaaa auucucaaca gaacuauacc aacaauuaaa cgaccuagaa      360

gcaugcguaa uccaagaagu agguguagaa gaaacaccac ucaugaacga agacucaaua      420

uuagcaguaa gaaaauacuu ccaaagaauc acacuauacu uaauagaaag aaaauacuca      480

ccaugcgcau gggaagucgu aagagcagaa auaaugagau cauuaucauu cucaacaaac      540

cuacaaaaac gacuaagaag aaaagacuaa                                       570


<210>  3985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01567

<400>  3985

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  3986
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAH74991

<400>  3986
auggcccggu ccuuuucuuu acugaugguc gugcugguac ucagcuacaa auccaucugc       60

ucucugggcu gugaucugcc ucagacccac agccugcgua auaggagggc cuugauacuc      120

cuggcacaaa ugggaagaau cucuccuuuc uccugcuuga aggacagaca ugaauucaga      180

uucccagagg aggaguuuga uggccaccag uuccagaaga cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacag aggacucauc ugcugcuugg      300

gaacagagcc uccuagaaaa auuuuccacu gaacuuuacc agcaacugaa ugaccuggaa      360

gcauguguga uacaggaggu ugggguggaa gagacucccc ugaugaauga ggacuucauc      420

cuggcuguga ggaaauacuu ccaaagaauc acucuuuauc uaauggagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuu uucaacaaac      540

uugaaaaaag gauuaaggag gaaggauuga                                       570


<210>  3987
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3987
auggcccgca gcuucucccu gcucauggug guccuggugc ugagcuacaa guccaucugc       60

agccucggcu gcgaccugcc ccagacccac ucccugcgga accgccgggc ccucauccug      120

cuggcgcaga uggggcgcau cagcccguuc uccugccuca aggaccggca cgaguuccgc      180

uuccccgagg aggaguucga cggccaccag uuccagaaga cccaggccau cagcgugcug      240

cacgagauga uccagcagac guucaaccug uucuccaccg aggacagcuc cgccgccugg      300

gagcagagcc uccuggagaa guucuccacc gagcuguacc agcagcucaa cgaccuggag      360

gccugcguca uccaggaggu ggggguggag gagacgcccc ugaugaacga ggacuucauc      420

cucgcggucc ggaaguacuu ccagcgcauc acccuguacc ugauggagaa gaaguacagc      480

cccugcgccu gggagguggu gcgggccgag aucaugcgcu ccuucagcuu cuccaccaac      540

cucaagaagg gccugcggcg caaggacuga                                       570


<210>  3988
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3988
auggcccgcu ccuucucccu ccucaugguc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccuccgca accgccgcgc ccucauccuc      120

cucgcccaga ugggccgcau cucccccuuc uccugccuca aggaccgcca cgaguuccgc      180

uuccccgagg aggaguucga cggccaccag uuccagaaga cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccaccg aggacuccuc cgccgccugg      300

gagcaguccc uccucgagaa guucuccacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca uccaggaggu cggcgucgag gagacccccc ucaugaacga ggacuucauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucauggagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucuccuu cuccaccaac      540

cucaagaagg gccuccgccg caaggacuga                                       570


<210>  3989
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3989
auggccagga gcuucucccu gcucauggug guccuuguuc ugucuuacaa gucaaucugc       60

aguuugggcu gugacuuacc ccagacccac agccugagaa accggcgcgc ucuaauucuc      120

cuggcacaaa uggggcgaau auccccuuuu ucuugccuua aagaucguca ugaguucaga      180

uuuccagaag aggaguucga cggacaccag uuucagaaga cacaggccau cucggugcug      240

caugaaauga uucaacagac uuucaauuug uuuucaacgg aagauagcag ugcggcuugg      300

gagcaguccc uccuggagaa auucucuacc gaacuguauc agcaacucaa cgacuuagag      360

gccuguguaa uccaggaagu gggugucgag gagacaccgc ugaugaauga agauuuuauu      420

cuugcaguga ggaaguacuu ccagcggauc acuuuguauc ugauggagaa aaaguacagc      480

cccugcgccu gggaaguugu gcgcgcugag auaaugagau ccuuuucauu caguaccaac      540

cuaaagaaag gccucaggcg gaaggacuga                                       570


<210>  3990
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3990
auggccagaa gcuucagccu gcugauggug gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugagaa acagaagagc ccugauccug      120

cuggcccaga ugggcagaau cagccccuuc agcugccuga aggacagaca cgaguucaga      180

uuccccgagg aggaguucga cggccaccag uuccagaaga cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcaccg aggacagcag cgccgccugg      300

gagcagagcc ugcuggagaa guucagcacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga uccaggaggu gggcguggag gagacccccc ugaugaacga ggacuucauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugauggagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagcuu cagcaccaac      540

cugaagaagg gccugagaag aaaggacuga                                       570


<210>  3991
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3991
auggcccgga gcuucucccu gcucauggug guccugguuc uuucuuacaa gagcaucugc       60

ucccugggcu gugaccuccc ccagacccac ucucugagaa accgcagagc ucuuauucug      120

cucgcccaaa uggggcggau cagcccuuuu uccugccuga aagaucgcca ugaguucaga      180

uuuccggaag aggaguucga cggacaccag uuucagaaga cacaggcgau uucugugcug      240

caugaaauga uccaacagac guucaaucuc uuuagcaccg aagauuccag cgcugccugg      300

gagcagucuc ugcuugagaa auucuccaca gaacuguauc agcaacucaa cgaccuggag      360

gccuguguga uucaggaagu cggcguggag gagacacccc uuaugaauga agauuuuauc      420

cuggcuguuc ggaaguacuu ccagcgcauc acccucuauc ugauggagaa aaaguacagc      480

ccuugcgccu gggaaguggu cagagcugag auuaugcggu cuuuuuccuu cagcaccaac      540

cugaagaaag ggcuccgcag aaaggacuga                                       570


<210>  3992
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAH74991

<400>  3992
auggcacgaa gcuucucacu acuaauggua guacuaguac uaucauacaa aagcauaugc       60

ucacucggau gcgaccuacc acaaacacac ucacuaagaa acagaagagc acucauacua      120

uuagcacaaa ugggacgaau aucaccauuc ucaugccuaa aagacagaca cgaauucaga      180

uucccagaag aagaauuuga cggacaccaa uuucaaaaaa cacaagcaau aagcguacua      240

cacgaaauga uacaacaaac auucaacuua uucucaacag aagacagcuc agcagcaugg      300

gaacaaucac uacuagaaaa auucuccaca gaacuauacc aacaacuaaa cgaccuagaa      360

gcaugcguaa uacaagaagu aggaguagaa gaaacaccac uaaugaacga agacuucaua      420

uuagcaguaa gaaaauacuu ccaaagaauc acacuauacc uaauggaaaa aaaauacuca      480

ccaugcgcau gggaaguagu aagagcagaa auaaugagau cauucucauu cucaacaaac      540

uuaaaaaaag gacuaagaag aaaagacuaa                                       570


<210>  3993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01568

<400>  3993

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  3994
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA52718

<400>  3994
auggcccugu ccuuuucuuu acugauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucugggcu gugaucugcc ucagacccac agccugggua auaggagggc cuugauacuc      120

cuggcacaaa ugggaagaau cucuccuuuc uccugccuga aggacagaca ugacuuugga      180

uucccccagg aggaguuuga uggcaaccag uuccagaagg cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacaa aggacucauc ugcuacuugg      300

gaacagagcc uccuagaaaa auuuuccacu gaacuuaacc agcagcugaa ugaccuggaa      360

gccugcguga uacaggaggu ugggguggaa gagacucccc ugaugaaugu ggacuccauc      420

cuggcuguga agaaauacuu ccaaagaauc acucuuuauc ugacagagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuu aucaaaaauu      540

uuucaagaaa gauuaaggag gaaggaauga                                       570


<210>  3995
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  3995
auggcccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc ccagacccac ucccucggga accgccgggc gcugauccug      120

cucgcccaga ugggccgcau cagcccguuc uccugccuga aggaccggca cgacuucggg      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccuc uucuccacga aggacagcuc cgccaccugg      300

gagcagagcc ugcuggagaa guucuccacc gagcucaacc agcagcugaa cgaccuggag      360

gcgugcguga uccaggaggu cgggguggag gagacgcccc ucaugaacgu ggacagcauc      420

cuggccguca agaaguacuu ccagcgcauc acccuguacc ucaccgagaa gaaguacucc      480

cccugcgccu gggagguggu gcgggccgag aucaugcgca gcuucucccu gagcaagauc      540

uuccaggagc ggcugcgccg gaaggaguga                                       570


<210>  3996
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  3996
auggcccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucgcccaga ugggccgcau cucccccuuc uccugccuca aggaccgcca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccacca aggacuccuc cgccaccugg      300

gagcaguccc uccucgagaa guucuccacc gagcucaacc agcagcucaa cgaccucgag      360

gccugcguca uccaggaggu cggcgucgag gagacccccc ucaugaacgu cgacuccauc      420

cucgccguca agaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucucccu cuccaagauc      540

uuccaggagc gccuccgccg caaggaguga                                       570


<210>  3997
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  3997
auggcccuga gcuucucccu ccuuauggcu gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ccagacccac agccuaggga acagaagggc acucauucug      120

cuugcccaaa ugggacggau auccccuuuu ucuugccuga aagaucgcca ugacuucggu      180

uuuccacagg aggaguucga uggcaaucag uuucagaagg cgcaagcuau cucgguuuug      240

cacgaaauga uucagcagac auucaaccuc uuuucaacua aagacagcag ugccacgugg      300

gaacaguccc ugcuggagaa guucucuacc gaacucaauc aacaguuaaa cgaucuggag      360

gcauguguga uccaggaggu agggguggaa gagacaccgc uuaugaaugu cgacagcauu      420

uuggccguga aaaaguauuu ucagcgaauc acucuguacc uaaccgaaaa gaaauauucc      480

cccugcgcuu gggagguugu gcgugcagag auaaugagau cauucagucu cagcaagauc      540

uuucaagaaa ggcugcggcg caaagaguga                                       570


<210>  3998
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  3998
auggcccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cuggcccaga ugggcagaau cagccccuuc agcugccuga aggacagaca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcacca aggacagcag cgccaccugg      300

gagcagagcc ugcuggagaa guucagcacc gagcugaacc agcagcugaa cgaccuggag      360

gccugcguga uccaggaggu gggcguggag gagacccccc ugaugaacgu ggacagcauc      420

cuggccguga agaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagccu gagcaagauc      540

uuccaggaga gacugagaag aaaggaguga                                       570


<210>  3999
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  3999
auggcccuga gcuucucccu ccugauggcu gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ccagacccac ucucuuggga acagacgggc ccugauucuc      120

cuggcgcaaa ugggacgcau cagcccuuuu uccugccuga aagauagaca ugacuucggc      180

uuuccgcagg aggaguucga ugggaaucag uuucagaagg cucaagccau uucuguucuc      240

cacgaaauga uccagcagac auucaaccug uuuagcacga aagacuccag cgccaccugg      300

gaacagucuc uucuggagaa guucuccaca gaacucaauc aacagcugaa cgaucuugag      360

gcuuguguga uucaggaggu gggagucgaa gagacacccc ugaugaaugu ggacagcauc      420

cucgccguua aaaaguauuu ucagcggauc acccuguacc ugaccgaaaa gaaauauucu      480

ccuugcgcuu gggagguggu ccgcgccgag auuaugagau ccuucagccu cucuaagauc      540

uuucaagaac ggcugcgcag aaaagaguga                                       570


<210>  4000
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA52718

<400>  4000
auggcacuau cauucucacu ccuaauggca guacucguac uaucauacaa aucaauaugc       60

ucacuaggau gcgaccuacc acaaacacac ucacucggaa accgaagagc acuaauacua      120

cuagcacaaa ugggacgaau aucaccauuc ucaugccuaa aagaccgaca cgacuucgga      180

uuuccacaag aagaauucga uggaaaccaa uuccaaaaag cccaagcaau aucaguauua      240

cacgaaauga uacaacaaac auucaaccua uuuucaacaa aagacucauc agcaacaugg      300

gaacaaucac uauuagaaaa auucucaaca gaacuaaacc aacaacuaaa cgaccuagaa      360

gcaugcguaa uacaagaagu aggaguagaa gaaacaccac uaaugaacgu agacucaaua      420

cuagcaguaa aaaaauacuu ccaaagaaua acacuauacc uaacagaaaa aaaauacuca      480

cccugcgcau gggaaguagu acgagcagaa auaaugagau cauucucauu aucaaaaaua      540

uuucaagaaa gacuaagaag aaaagaauaa                                       570


<210>  4001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01569

<400>  4001

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  4002
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAH93755

<400>  4002
auggccuugc ccuuuguuuu acugauggcc cugguggugc ucaacugcaa gucaaucugu       60

ucucugggcu gugaucugcc ucagacccac agccugagua acaggaggac uuugaugaua      120

auggcacaaa ugggaagaau cucuccuuuc uccugccuga aggacagaca ugacuuugga      180

uuuccucagg aggaguuuga uggcaaccag uuccagaagg cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacaa aggacucauc ugcuacuugg      300

gaugagacac uucuagacaa auucuacacu gaacuuuacc agcagcugaa ugaccuggaa      360

gccuguauga ugcaggaggu uggaguggaa gacacuccuc ugaugaaugu ggacucuauc      420

cugacuguga gaaaauacuu ucaaagaauc acccucuauc ugacagagaa gaaauacagc      480

ccuugugcau gggagguugu cagagcagaa aucaugagau ccuucucuuu aucagcaaac      540

uugcaagaaa gauuaaggag gaaggaauga                                       570


<210>  4003
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4003
auggcccugc ccuucgugcu ccugauggcc cuggucgugc ucaacugcaa gagcaucugc       60

ucccugggcu gcgaccugcc gcagacccac agccucucca accgccggac ccugaugauc      120

auggcgcaga uggggcgcau cagccccuuc uccugccuga aggaccggca cgacuucggc      180

uucccccagg aggaguucga cgggaaccag uuccagaagg cccaggccau cagcgugcuc      240

cacgagauga uccagcagac guucaaccug uucuccacca aggacagcuc cgccaccugg      300

gacgagaccc ugcucgacaa guucuacacg gagcuguacc agcagcugaa cgaccucgag      360

gccugcauga ugcaggaggu cggcguggag gacacgcccc ugaugaacgu ggacagcauc      420

cugaccgucc gcaaguacuu ccagcggauc acccucuacc ugaccgagaa gaaguacucc      480

ccgugcgcgu gggagguggu gcgcgccgag aucaugcgga gcuucucccu gagcgccaac      540

cuccaggagc gccugcggcg caaggaguga                                       570


<210>  4004
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4004
auggcccucc ccuucguccu ccucauggcc cucgucgucc ucaacugcaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucucca accgccgcac ccucaugauc      120

auggcccaga ugggccgcau cucccccuuc uccugccuca aggaccgcca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccacca aggacuccuc cgccaccugg      300

gacgagaccc uccucgacaa guucuacacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcauga ugcaggaggu cggcgucgag gacacccccc ucaugaacgu cgacuccauc      420

cucaccgucc gcaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucucccu cuccgccaac      540

cuccaggagc gccuccgccg caaggaguga                                       570


<210>  4005
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4005
auggcccugc ccuucgugcu ccuuauggcu cuggucguuu ugaacugcaa gagcaucugu       60

uccuuaggcu gcgaccugcc ucagacccac ucucuaucaa auagaaggac acucaugauu      120

auggcacaaa uggggcggau aaguccauuu agcugucuga aagaucgcca ugacuucgga      180

uuuccgcagg aggaguucga ugguaaccag uuucagaagg cccaagcgau cuccgugcuu      240

cacgaaauga uucagcagac uuucaaucug uuuucuacga aagacucguc agcuaccugg      300

gaugaaacau ugcucgacaa guucuacacu gagcuguauc agcaacugaa cgaucucgaa      360

gccugcauga ugcaggaggu aggcguggag gacacccccu uaaugaaugu cgauagcauc      420

cugacagugc gaaaauacuu ucagcguauu acccuuuauu ugacugaaaa gaaguacagu      480

ccuugugcau gggagguugu gagagccgaa aucaugaggu ccuucucucu gagcgcuaac      540

cuacaggagc ggcuccgcag aaaagaguga                                       570


<210>  4006
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4006
auggcccugc ccuucgugcu gcugauggcc cugguggugc ugaacugcaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugagca acagaagaac ccugaugauc      120

auggcccaga ugggcagaau cagccccuuc agcugccuga aggacagaca cgacuucggc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcacca aggacagcag cgccaccugg      300

gacgagaccc ugcuggacaa guucuacacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcauga ugcaggaggu gggcguggag gacacccccc ugaugaacgu ggacagcauc      420

cugaccguga gaaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagccu gagcgccaac      540

cugcaggaga gacugagaag aaaggaguga                                       570


<210>  4007
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4007
auggcccugc ccuucgugcu ccugauggcu cuugucguuc ugaacugcaa gagcaucugu       60

ucccucggcu gcgaccugcc ucagacccac ucucuuagca auagacggac acugaugauu      120

auggcccaaa uggggcgcau cuccccguuu ucuugucuca aagauagaca ugacuucgga      180

uuuccccagg aggaguucga uggcaaccag uuucagaagg cgcaagcuau uagcgugcug      240

cacgaaauga uccagcagac guucaaucug uuuuccacca aagacucuag cgccacaugg      300

gaugaaaccc uccuggacaa guucuacaca gagcuuuauc agcaacugaa cgaucucgaa      360

gccugcauga ugcaggaggu gggggucgag gacaccccuc ugaugaaugu ggauuccauu      420

cuuacaguuc ggaaauacuu ucagcgcauc acccuguauc ucacggaaaa gaaguacagc      480

cccugugcuu gggagguggu cagagccgaa aucaugcggu cuuucucccu gagcgcuaac      540

cugcaggagc gccucagacg gaaagaguga                                       570


<210>  4008
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAH93755

<400>  4008
auggcacuac cauucguacu acuaauggca cuaguaguac ucaauugcaa aucaauaugc       60

ucacuaggau gcgacuuacc acaaacacac ucacuaucaa acagaagaac acuaaugaua      120

auggcacaaa ugggacgaau aagcccauuc ucaugccuaa aagacagaca cgauuucgga      180

uucccacaag aagaauucga cggaaaccaa uuccaaaaag cacaagcaau aucaguauua      240

cacgaaauga uacaacaaac auucaaccua uucucaacaa aagacucauc agcaacaugg      300

gacgaaacac uucuagacaa auucuacaca gaacuauauc aacaacuaaa cgaccuagaa      360

gcaugcauga ugcaagaagu aggaguagaa gacacaccac uaaugaacgu agacucaauu      420

cuaacaguac gaaaauacuu ccaaagaaua acacuauacu uaacagaaaa aaaauacuca      480

ccaugcgcau gggaaguagu aagagccgaa auaaugagau cauucucacu aucagcaaac      540

cuacaagaaa gacuaagaag aaaagaauaa                                       570


<210>  4009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01570

<400>  4009

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  4010
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAH74956

<400>  4010
auggcauugc ccuuugcuuu aaugauggcc cugguggugc ucagcugcaa gucaagcugc       60

ucucugggcu guaaucuguc ucaaacccac agccugaaua acaggaggac uuugaugcuc      120

auggcacaaa ugaggagaau cucuccuuuc uccugccuga aggacagaca ugacuuugaa      180

uuuccccagg aggaauuuga uggcaaccag uuccagaaag cucaagccau cucuguccuc      240

caugagauga ugcagcagac cuucaaucuc uucagcacaa agaacucauc ugcugcuugg      300

gaugagaccc uccuagaaaa auucuacauu gaacuuuucc agcaaaugaa ugaccuggaa      360

gccuguguga uacaggaggu ugggguggaa gagacucccc ugaugaauga ggacuccauc      420

cuggcuguga agaaauacuu ccaaagaauc acucuuuauc ugauggagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau cccucucuuu uucaacaaac      540

uugcaaaaaa gauuaaggag gaaggauuga                                       570


<210>  4011
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4011
auggcccugc ccuucgcccu caugauggcg cugguggucc ugagcugcaa guccagcugc       60

ucccucggcu gcaaccugag ccagacccac ucccugaaca accgccggac ccucaugcug      120

auggcccaga ugcgccggau cagcccguuc uccugccuga aggaccgcca cgacuucgag      180

uucccccagg aggaguucga cgggaaccag uuccagaagg cccaggccau cagcgugcuc      240

cacgagauga ugcagcagac guucaaccug uucuccacca agaacagcuc cgccgcgugg      300

gacgagaccc ugcucgagaa guucuacauc gagcuguucc agcagaugaa cgaccuggag      360

gccugcguga uccaggaggu cggcguggag gagacgcccc ucaugaacga ggacagcauc      420

cuggccguga agaaguacuu ccagcggauc acccuguacc ucauggagaa gaaguacucc      480

cccugcgccu gggaggucgu gcgcgcggag aucaugcgga gccuguccuu cagcaccaac      540

cugcagaagc gccuccggcg caaggacuga                                       570


<210>  4012
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4012
auggcccucc ccuucgcccu caugauggcc cucgucgucc ucuccugcaa guccuccugc       60

ucccucggcu gcaaccucuc ccagacccac ucccucaaca accgccgcac ccucaugcuc      120

auggcccaga ugcgccgcau cucccccuuc uccugccuca aggaccgcca cgacuucgag      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga ugcagcagac cuucaaccuc uucuccacca agaacuccuc cgccgccugg      300

gacgagaccc uccucgagaa guucuacauc gagcucuucc agcagaugaa cgaccucgag      360

gccugcguca uccaggaggu cggcgucgag gagacccccc ucaugaacga ggacuccauc      420

cucgccguca agaaguacuu ccagcgcauc acccucuacc ucauggagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu cccucuccuu cuccaccaac      540

cuccagaagc gccuccgccg caaggacuga                                       570


<210>  4013
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4013
auggcccugc ccuucgcucu caugauggca cuuguggucc ugagcugcaa guccucuugu       60

ucauugggcu gcaacuuaag ucagacccac agccugaaua acagaaggac acuaaugcuc      120

auggcccaaa ugcggcgcau cuccccuuuu ucuugucuga aagaccgaca ugauuucgag      180

uuuccacagg aagaguucga cgggaaucag uuucagaagg cgcaagcuau uucgguucuu      240

cacgaaauga ugcagcagac uuucaaccug uuuucaacga aaaauagcag ugccgcaugg      300

gaugagaccu ugcucgaaaa guucuacaua gagcuguuuc agcaaaugaa cgaccuggag      360

gccugcguga uccaggaagu aggaguggag gaaacaccgc ucaugaauga ggauuccauu      420

uuagcuguca aaaaguauuu ccagcguauc acucuguacc uuauggagaa gaaauauucu      480

cccugugcau gggaaguggu uagagccgag auuaugagga gcuuguccuu uucaaccaac      540

cugcagaagc ggcuacgcag aaaagacuga                                       570


<210>  4014
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4014
auggcccugc ccuucgcccu gaugauggcc cugguggugc ugagcugcaa gagcagcugc       60

agccugggcu gcaaccugag ccagacccac agccugaaca acagaagaac ccugaugcug      120

auggcccaga ugagaagaau cagccccuuc agcugccuga aggacagaca cgacuucgag      180

uucccccagg aggaguucga cggcaaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga ugcagcagac cuucaaccug uucagcacca agaacagcag cgccgccugg      300

gacgagaccc ugcuggagaa guucuacauc gagcuguucc agcagaugaa cgaccuggag      360

gccugcguga uccaggaggu gggcguggag gagacccccc ugaugaacga ggacagcauc      420

cuggccguga agaaguacuu ccagagaauc acccuguacc ugauggagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gccugagcuu cagcaccaac      540

cugcagaaga gacugagaag aaaggacuga                                       570


<210>  4015
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4015
auggcccugc ccuucgcucu caugauggcc cugguggucc uuagcugcaa guccucuugu       60

agccugggcu gcaaccucuc ccagacccac ucucugaaua acagacggac acuuaugcug      120

auggcgcaaa ugcgcagaau cagcccuuuu uccugucuca aagaccggca ugauuucgag      180

uuuccgcagg aagaguucga cgggaaucag uuucagaagg cucaagccau uucuguucug      240

cacgaaauga ugcagcagac guucaaccug uuuagcacca aaaauuccag cgccgcuugg      300

gaugagacac uccuggaaaa guucuacauc gagcuuuuuc agcaaaugaa cgaccuggag      360

gccugcguga uucaggaagu gggagucgag gaaacacccc ucaugaauga ggauucuauc      420

cuggcuguga aaaaguauuu ccagcgcauu acccuuuacc ugauggagaa gaaauauucc      480

ccuugugccu gggaaguugu gagagcggag aucaugcgga gccucucuuu uuccaccaac      540

cugcagaagc gccugagacg gaaagacuga                                       570


<210>  4016
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAH74956

<400>  4016
auggcacuac cauucgcacu aaugauggca cuaguaguac uaucaugcaa aucaucaugc       60

ucacuaggau gcaaccuauc acaaacacac ucacucaaca acagaagaac acuaauguua      120

auggcacaaa ugagaagaau aucaccauuc ucaugccuaa aagacagaca cgacuucgaa      180

uucccacaag aagaauucga cggaaaccaa uuccaaaaag cacaagcaau aucaguacua      240

cacgaaauga ugcaacaaac auucaaccua uucucaacaa aaaacucauc agcagcaugg      300

gacgaaacac uauuagaaaa auucuacaua gaacuauucc aacaaaugaa cgaccuagaa      360

gcaugcguaa uacaagaagu aggaguagaa gaaacaccau uaaugaacga agacucaaua      420

cuagcaguaa aaaaauacuu ccaaagaaua acacuauacc uaauggaaaa aaaauacagc      480

ccaugcgcau gggaagucgu aagagcagaa auaaugagaa gccuaagcuu cagcacuaac      540

cuacaaaaaa gacuacgaag aaaagacuaa                                       570


<210>  4017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P01571

<400>  4017

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  4018
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA52725

<400>  4018
auggcccugu ccuuuucuuu acugauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucuaggcu gugaucugcc ucagacccac agccugggua auaggagggc cuugauacuc      120

cuggcacaaa ugggaagaau cucuccuuuc uccugccuga aggacagaca ugacuuugga      180

cuuccccagg aggaguuuga uggcaaccag uuccagaaga cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacag aggacucauc ugcugcuugg      300

gaacagagcc uccuagaaaa auuuuccacu gaacuuuacc agcaacugaa uaaccuggaa      360

gcauguguga uacaggaggu ugggauggaa gagacucccc ugaugaauga ggacuccauc      420

cuggcuguga ggaaauacuu ccaaagaauc acucuuuauc uaacagagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau cccucucuuu uucaacaaac      540

uugcaaaaaa uauuaaggag gaaggauuga                                       570


<210>  4019
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4019
auggcccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc ccagacccac ucccucggga accgccgggc gcugauccug      120

cucgcccaga ugggccgcau cagcccguuc uccugccuga aggaccggca cgacuucggg      180

cugccccagg aggaguucga cggcaaccag uuccagaaga cccaggccau cagcgugcuc      240

cacgagauga uccagcagac guucaaccug uucuccaccg aggacagcuc cgccgccugg      300

gagcagagcc ugcucgagaa guucuccacc gagcuguacc agcagcugaa caaccucgag      360

gcgugcguga uccaggaggu cgggauggag gagacgcccc ugaugaacga ggacagcauc      420

cuggccgugc gcaaguacuu ccagcggauc acccucuacc ugaccgagaa gaaguacucc      480

cccugcgccu gggagguggu ccgcgccgag aucaugcgga gccuguccuu cagcaccaac      540

cuccagaaga uccugcgccg gaaggacuga                                       570


<210>  4020
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4020
auggcccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucgcccaga ugggccgcau cucccccuuc uccugccuca aggaccgcca cgacuucggc      180

cucccccagg aggaguucga cggcaaccag uuccagaaga cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccaccg aggacuccuc cgccgccugg      300

gagcaguccc uccucgagaa guucuccacc gagcucuacc agcagcucaa caaccucgag      360

gccugcguca uccaggaggu cggcauggag gagacccccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu cccucuccuu cuccaccaac      540

cuccagaaga uccuccgccg caaggacuga                                       570


<210>  4021
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4021
auggcccuga gcuucucccu ccuuauggcu gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ccagacccac agccuaggga acagaagggc acucauucug      120

cuugcccaaa ugggacggau auccccuuuu ucuugccuga aagaucgcca ugacuucggu      180

uugccacagg aggaauuuga uggcaaucag uuccagaaga cacaagcgau cucgguucuc      240

cacgagauga uucagcagac uuuuaaccug uucucaacgg aagacagcag ugcugccugg      300

gagcaguccc ugcucgaaaa auuuucuacc gaguuauauc aacagcugaa uaaccuugag      360

gcauguguga uccaggaagu agggauggag gaaacaccgu ugaugaauga ggauagcauu      420

cuggccgugc gaaaguacuu ccagcguauc acucuauauc ucaccgagaa aaaguacucc      480

cccugcgcuu gggaagucgu gagagcagag auaaugaggu cacugaguuu uagcacaaac      540

cuucaaaaga uccugcggcg caaagacuga                                       570


<210>  4022
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4022
auggcccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cuggcccaga ugggcagaau cagccccuuc agcugccuga aggacagaca cgacuucggc      180

cugccccagg aggaguucga cggcaaccag uuccagaaga cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcaccg aggacagcag cgccgccugg      300

gagcagagcc ugcuggagaa guucagcacc gagcuguacc agcagcugaa caaccuggag      360

gccugcguga uccaggaggu gggcauggag gagacccccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gccugagcuu cagcaccaac      540

cugcagaaga uccugagaag aaaggacuga                                       570


<210>  4023
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4023
auggcccuga gcuucucccu ccugauggcu gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ccagacccac ucucuuggga acagacgggc ccugauucuc      120

cuggcgcaaa ugggacgcau cagcccuuuu uccugccuga aagauagaca ugacuucggc      180

cucccgcagg aggaauuuga ugggaaucag uuccagaaga cacaagcuau uucuguucug      240

cacgagauga uccagcagac guuuaaccuu uucagcaccg aagacuccag cgccgccugg      300

gagcagucuc ugcucgaaaa auuuuccaca gagcuguauc aacagcuuaa uaaccuggag      360

gcuuguguga uucaggaagu gggaauggag gaaacacccc ucaugaauga ggauagcauc      420

cuggccgucc ggaaguacuu ccagcgcauc acccuguauc ucaccgagaa aaaguacucu      480

ccuugcgcuu gggaaguggu uagagccgag auuaugcggu cccugagcuu uucuacaaac      540

cuucaaaaga uccugcgcag aaaagacuga                                       570


<210>  4024
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA52725

<400>  4024
auggcacuau cauucucacu acuaauggca guacucguac uaucauacaa aucaauaugc       60

ucacucggau gcgaccuacc acaaacacac ucauuaggaa acagaagagc acucauacua      120

cuagcacaaa ugggaagaau aucaccauuc ucaugccuaa aagacagaca ugacuucgga      180

uuaccacaag aagaauucga cggaaaccaa uuccaaaaaa cacaagcaau aucaguacuc      240

cacgaaauga uacaacaaac auucaacuua uucucaacag aagacucauc agcagcaugg      300

gaacaaucac uacuagaaaa auucucaaca gaacuauacc aacaacuaaa caaccuagaa      360

gcaugcguaa uacaagaagu aggcauggaa gaaacaccac uaaugaacga agacucaaua      420

cuagcaguaa gaaaauacuu ccaaagaaua acacuauacu uaacagaaaa aaaauauuca      480

ccaugcgcau gggaaguagu acgcgcagaa auaaugagaa gccuaagcuu cuccacaaac      540

cuacaaaaaa uauuaagaag aaaagacuaa                                       570


<210>  4025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P05013

<400>  4025

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  4026
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAH69471

<400>  4026
auggcuuugc cuuuugcuuu acugauggcc cugguggugc ucagcugcaa gucaagcugc       60

ucucuggacu gugaucugcc ucagacccac agccuggguc acaggaggac caugaugcuc      120

cuggcacaaa ugaggagaau cucucuuuuc uccugucuga aggacagaca ugacuucaga      180

uuuccccagg aggaguuuga uggcaaccag uuccagaagg cugaagccau cucuguccuc      240

caugagguga uucagcagac cuucaaccuc uucagcacaa aggacucauc uguugcuugg      300

gaugagaggc uucuagacaa acucuauacu gaacuuuacc agcagcugaa ugaccuggaa      360

gccuguguga ugcaggaggu guggguggga gggacucccc ugaugaauga ggacuccauc      420

cuggcuguga gaaaauacuu ccaaagaauc acucucuacc ugacagagaa aaaguacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuc aucaagaaac      540

uugcaagaaa gguuaaggag gaaggaauaa                                       570


<210>  4027
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4027
auggcccugc ccuucgcccu ccugauggcg cugguggucc ucagcugcaa guccagcugc       60

ucccuggacu gcgaccugcc gcagacccac agccucggcc accgccggac caugaugcug      120

cuggcccaga ugcgccggau cucccucuuc agcugccuga aggaccgcca cgacuuccgg      180

uucccccagg aggaguucga cgggaaccag uuccagaagg ccgaggccau cuccgugcug      240

cacgagguga uccagcagac guucaaccuc uucagcacca aggacuccag cgucgccugg      300

gacgagcgcc ugcuggacaa gcucuacacc gagcuguacc agcagcugaa cgaccucgag      360

gcgugcguga ugcaggaggu gugggucggc gggacgcccc ugaugaacga ggacuccauc      420

cuggccgugc ggaaguacuu ccagcgcauc acccucuacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu ccgggccgag aucaugcgcu ccuucagcuc cagccggaac      540

cugcaggagc gccuccggcg caaggaguga                                       570


<210>  4028
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4028
auggcccucc ccuucgcccu ccucauggcc cucgucgucc ucuccugcaa guccuccugc       60

ucccucgacu gcgaccuccc ccagacccac ucccucggcc accgccgcac caugaugcuc      120

cucgcccaga ugcgccgcau cucccucuuc uccugccuca aggaccgcca cgacuuccgc      180

uucccccagg aggaguucga cggcaaccag uuccagaagg ccgaggccau cuccguccuc      240

cacgagguca uccagcagac cuucaaccuc uucuccacca aggacuccuc cgucgccugg      300

gacgagcgcc uccucgacaa gcucuacacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca ugcaggaggu cugggucggc ggcacccccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucuccuc cucccgcaac      540

cuccaggagc gccuccgccg caaggaguga                                       570


<210>  4029
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4029
auggcccugc ccuucgcucu ccuuauggca cugguggucu ugagcugcaa guccucuugu       60

ucauuagacu gcgaucugcc ucagacccac agucuaggcc auagaaggac aaugaugcuc      120

cuggcccaaa ugcggcgcau cagccuuuuc uccugucuga aagaccgaca cgauuuccgu      180

uuuccacagg aggaauuuga cgggaaccag uuucagaagg cggaggcuau uucuguuuug      240

caugaaguga uacaacagac uuucaaucuc uuuucgacga aagauucaag cguagccugg      300

gacgagagac ugcuggauaa gcucuacacc gaauuauauc agcagcugaa cgaccuugag      360

gcaugcguga ugcaagaggu cuggguggga gguacaccgu ugaugaauga agauaguauc      420

cuggccguua ggaaauacuu ccagcggauu acucuauauc ucaccgagaa gaaguacucc      480

cccugugcuu gggaaguggu ccgcgcagag aucaugagau cuuuuagcuc cucaaggaac      540

cugcaggagc ggcuucgccg aaaagaauga                                       570


<210>  4030
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4030
auggcccugc ccuucgcccu gcugauggcc cugguggugc ugagcugcaa gagcagcugc       60

agccuggacu gcgaccugcc ccagacccac agccugggcc acagaagaac caugaugcug      120

cuggcccaga ugagaagaau cagccuguuc agcugccuga aggacagaca cgacuucaga      180

uucccccagg aggaguucga cggcaaccag uuccagaagg ccgaggccau cagcgugcug      240

cacgagguga uccagcagac cuucaaccug uucagcacca aggacagcag cguggccugg      300

gacgagagac ugcuggacaa gcuguacacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga ugcaggaggu gugggugggc ggcacccccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagcag cagcagaaac      540

cugcaggaga gacugagaag aaaggaguga                                       570


<210>  4031
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4031
auggcccugc ccuucgcucu ccugauggcc cuuguggucc ugagcugcaa guccucuugu       60

agccucgacu gcgaucugcc ucagacccac ucccuuggcc auagacggac aaugaugcug      120

cucgcgcaaa ugcgcagaau cucucuguuu agcugucuga aagaccggca cgauuuccgc      180

uuuccgcagg aggaguucga cgggaaccag uuucagaagg cugaagccau uuccguucuc      240

caugaaguga uccaacagac guucaaucug uuuucuacca aagauagcuc cguggccugg      300

gacgagagac uucuggauaa gcucuacaca gaacuguauc agcagcuuaa cgaccuggag      360

gcuugcguca ugcaagaggu guggguugga ggcacacccc ucaugaauga agauagcauu      420

cuggccgugc ggaaauacuu ccagcgcauc acccuguauc ucaccgagaa gaaguacucu      480

ccuugugcuu gggaagucgu gagagccgag auuaugcggu ccuuuucuag cucccgcaac      540

cugcaggaga gacuucggcg caaagaauga                                       570


<210>  4032
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAH69471

<400>  4032
auggcauuac cauucgcacu acuaauggca uuaguaguau uaucauguaa aagcucaugc       60

ucacuagacu gcgaccuacc acaaacacac ucauuaggac acagaagaac aaugaugcuc      120

cuagcacaaa ugagaagaau aucacuauuc ucaugcuuaa aagacagaca cgacuucaga      180

uucccacaag aagaauucga cggaaaccaa uuccaaaaag cagaagcaau aucaguauua      240

cacgaaguaa uacaacaaac auucaaccua uucucaacaa aagacucauc ugucgcaugg      300

gacgaaagac uacuagacaa acuauacaca gaauuauacc aacaacuaaa cgacuuagaa      360

gcaugcguaa ugcaagaagu auggguagga ggaacaccac uaaugaacga agacucaaua      420

cuagcaguaa gaaaauacuu ccaaagaaua accuuauacc uaacagaaaa aaaauacuca      480

ccaugugcau gggaaguagu aagagcagaa auaaugagau cauucucauc aucaagaaau      540

cuacaagaaa gacuacgaag aaaagaauaa                                       570


<210>  4033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P05014

<400>  4033

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  4034
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA52726

<400>  4034
auggcccugu ccuuuucuuu acugauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucugggcu gugaucugcc ucagacccac agccugggua auaggagggc cuugauacuc      120

cuggcacaaa ugggaagaau cucucauuuc uccugccuga aggacagaca ugauuucgga      180

uuccccgagg aggaguuuga uggccaccag uuccagaagg cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaucuc uucagcacag aggacucauc ugcugcuugg      300

gaacagagcc uccuagaaaa auuuuccacu gaacuuuacc agcaacugaa ugaccuggaa      360

gcauguguga uacaggaggu ugggguggaa gagacucccc ugaugaauga ggacuccauc      420

cuggcuguga ggaaauacuu ccaaagaauc acucuuuauc uaacagagaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau cccucucguu uucaacaaac      540

uugcaaaaaa gauuaaggag gaaggauuga                                       570


<210>  4035
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4035
auggcccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc ccagacccac ucccucggga accgccgggc gcugauccug      120

cucgcccaga ugggccgcau cagccacuuc uccugccuga aggaccggca cgacuucggg      180

uucccggagg aggaguucga cggccaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccuc uucuccacgg aggacagcuc cgccgcgugg      300

gagcagagcc ugcuggagaa guucuccacc gagcucuacc agcagcugaa cgaccuggag      360

gccugcguga uccaggaggu cgggguggag gagacgcccc ucaugaacga ggacagcauc      420

cuggccgugc gcaaguacuu ccagcggauc acccuguacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu gcgcgcggag aucaugcgga gccuguccuu cagcaccaac      540

cugcagaagc gccuccggcg caaggacuga                                       570


<210>  4036
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4036
auggcccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucgcccaga ugggccgcau cucccacuuc uccugccuca aggaccgcca cgacuucggc      180

uuccccgagg aggaguucga cggccaccag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccaccg aggacuccuc cgccgccugg      300

gagcaguccc uccucgagaa guucuccacc gagcucuacc agcagcucaa cgaccucgag      360

gccugcguca uccaggaggu cggcgucgag gagacccccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu cccucuccuu cuccaccaac      540

cuccagaagc gccuccgccg caaggacuga                                       570


<210>  4037
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4037
auggcccuga gcuucucccu ccuuauggcu gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ccagacccac agccuaggga acagaagggc acucauucug      120

cuugcccaaa ugggacggau aucccauuuu ucuugccuga aagaucgcca cgacuucggu      180

uuuccugagg aagaguucga uggccaucag uuucagaagg cgcaggcuau cucgguuuug      240

cacgaaauga uucaacagac auucaaucuc uuuucaacug aggacagcag ugccgcaugg      300

gaacaguccc ugcuggagaa auucucuacg gagcucuauc agcaauuaaa cgaucuggaa      360

gccuguguga uccaggaggu agggguggaa gagaccccac uuaugaauga ggacagcauu      420

uuggcugucc gaaaguacuu ucagcguauc acacuguauc uaacugagaa aaaguacucc      480

ccgugcgcau gggaaguggu uagagccgaa auaaugaggu cacucaguuu cagcaccaac      540

cugcagaagc ggcuucgcag aaaagauuga                                       570


<210>  4038
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4038
auggcccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cuggcccaga ugggcagaau cagccacuuc agcugccuga aggacagaca cgacuucggc      180

uuccccgagg aggaguucga cggccaccag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcaccg aggacagcag cgccgccugg      300

gagcagagcc ugcuggagaa guucagcacc gagcuguacc agcagcugaa cgaccuggag      360

gccugcguga uccaggaggu gggcguggag gagacccccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gccugagcuu cagcaccaac      540

cugcagaaga gacugagaag aaaggacuga                                       570


<210>  4039
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4039
auggcccuga gcuucucccu ccugauggcu gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ccagacccac ucucuuggga acagacgggc ccugauucuc      120

cuggcgcaaa ugggacgcau cagccauuuu uccugccuga aagauagaca cgacuucggc      180

uuuccugagg aagaguucga ugggcaucag uuucagaagg cucaggccau uucuguucuc      240

cacgaaauga uccaacagac auucaaucug uuuagcacgg aggacuccag cgccgcuugg      300

gaacagucuc uucuggagaa auucuccacc gagcucuauc agcaacugaa cgaucuugaa      360

gccuguguga uucaggaggu gggagucgaa gagacaccgc ugaugaauga ggacagcauc      420

cucgcugugc ggaaguacuu ucagcgcauc acccuguauc ugacagagaa aaaguacucu      480

cccugcgccu gggaaguugu gagagcggaa auuaugcggu cccucagcuu cucuaccaac      540

cugcagaagc gccuuagacg gaaagauuga                                       570


<210>  4040
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA52726

<400>  4040
auggcauuaa gcuucucacu acucauggcc guacuaguac uaucauacaa aucaauaugc       60

ucacuaggau gcgaucuacc acaaacacac ucccuaggaa acagaagagc acuaauacuc      120

cuagcacaaa ugggacgaau aagccacuuc ucaugccuaa aagacagaca cgacuucgga      180

uucccagaag aagaauucga cggacaccaa uuccaaaaag cacaagcaau aucaguacua      240

cacgaaauga uacaacaaac auucaaccuc uucucaacag aagacucauc agcagcaugg      300

gaacaaucac uacuagaaaa auucucaaca gaacuauacc aacaacuaaa cgaccuagaa      360

gcaugcguaa uacaagaagu aggaguagaa gaaacaccac uaaugaacga agacucaaua      420

cuagcaguaa gaaaauacuu ccaaagaaua acacuauacc uaaccgaaaa aaaauacuca      480

ccaugcgcau gggaaguagu aagagcagaa auaaugagaa gccuaucauu cucaacaaac      540

cuacaaaaaa gacuaagacg aaaagacuaa                                       570


<210>  4041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P05015

<400>  4041

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  4042
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA36042

<400>  4042
auggcccugu ccuuuucuuu acugauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucugggcu gugaucugcc ucagacucac agccugggua auaggagggc cuugauacuc      120

cuggcacaaa ugggaagaau cucucauuuc uccugccuga aggacagaua ugauuucgga      180

uucccccagg agguguuuga uggcaaccag uuccagaagg cucaagccau cucugccuuc      240

caugagauga uccagcagac cuucaaucuc uucagcacaa aggauucauc ugcugcuugg      300

gaugagaccc uccuagacaa auucuacauu gaacuuuucc agcaacugaa ugaccuagaa      360

gccuguguga cacaggaggu ugggguggaa gagauugccc ugaugaauga ggacuccauc      420

cuggcuguga ggaaauacuu ucaaagaauc acucuuuauc ugauggggaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuu uucaacaaac      540

uugcaaaaag gauuaagaag gaaggauuga                                       570


<210>  4043
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4043
auggcccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc ccagacccac ucccucggga accgccgggc gcugauccug      120

cucgcccaga ugggccgcau cagccacuuc uccugccuga aggaccggua cgacuucggg      180

uucccgcagg agguguucga cggcaaccag uuccagaagg cccaggccau cagcgccuuc      240

cacgagauga uccagcagac cuucaaccug uucuccacga aggacagcuc cgcggccugg      300

gacgagaccc uccuggacaa guucuacauc gagcuguucc agcagcucaa cgaccuggag      360

gccugcguga cccaggaggu cgggguggag gagaucgccc ugaugaacga ggacagcauc      420

cucgcggugc gcaaguacuu ccagcggauc acccuguacc ugaugggcaa gaaguacucc      480

cccugcgccu gggaggucgu gcgcgccgag aucaugcgga gcuucuccuu cagcacgaac      540

cuccagaagg gccugcgccg gaaggacuga                                       570


<210>  4044
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4044
auggcccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucgcccaga ugggccgcau cucccacuuc uccugccuca aggaccgcua cgacuucggc      180

uucccccagg aggucuucga cggcaaccag uuccagaagg cccaggccau cuccgccuuc      240

cacgagauga uccagcagac cuucaaccuc uucuccacca aggacuccuc cgccgccugg      300

gacgagaccc uccucgacaa guucuacauc gagcucuucc agcagcucaa cgaccucgag      360

gccugcguca cccaggaggu cggcgucgag gagaucgccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaugggcaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucuccuu cuccaccaac      540

cuccagaagg gccuccgccg caaggacuga                                       570


<210>  4045
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4045
auggcccuga gcuucucccu ccuuauggcu gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ccagacccac agccuaggga acagaagggc acucauucug      120

cuugcccaaa ugggacggau aucccauuuu ucuugccuga aagaucgcua ugacuucggu      180

uuuccucagg agguuuucga uggcaaucag uuucagaagg cgcaagcuau cucggccuuc      240

cacgaaauga uucagcagac auuuaacuug uucucaacua aagacagcag ugcagccugg      300

gaugagacgc uccuggacaa guuuuacauc gaacuguucc agcaacucaa ugauuuagag      360

gcuuguguga cccaggaagu agggguggag gagauugcac ugaugaacga agacuccauc      420

cuugccgucc gaaaauauuu ucagcguaua acauuguacc ugaugggaaa gaaguauucu      480

ccaugcgcuu gggagguggu uagagccgaa aucaugagga gcuucuccuu uucaacuaau      540

cuacagaaag gccuccggcg caaggauuga                                       570


<210>  4046
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4046
auggcccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cuggcccaga ugggcagaau cagccacuuc agcugccuga aggacagaua cgacuucggc      180

uucccccagg agguguucga cggcaaccag uuccagaagg cccaggccau cagcgccuuc      240

cacgagauga uccagcagac cuucaaccug uucagcacca aggacagcag cgccgccugg      300

gacgagaccc ugcuggacaa guucuacauc gagcuguucc agcagcugaa cgaccuggag      360

gccugcguga cccaggaggu gggcguggag gagaucgccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaugggcaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagcuu cagcaccaac      540

cugcagaagg gccugagaag aaaggacuga                                       570


<210>  4047
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4047
auggcccuga gcuucucccu ccugauggcu gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ccagacccac ucucuuggga acagacgggc ccugauucuc      120

cuggcgcaaa ugggacgcau cagccauuuu uccugccuga aagauagaua ugacuucggc      180

uuuccucagg agguuuucga ugggaaucag uuucagaagg cucaagccau uucugccuuc      240

cacgaaauga uccagcagac auuuaaccuc uucagcacga aagacuccag cgcugccugg      300

gaugagaccc ugcuugacaa guuuuacauu gaacuguucc agcaacucaa ugaucuggag      360

gcuuguguga cacaggaagu gggagucgag gagaucgccc uuaugaacga agacucuauc      420

cuggcggugc ggaaauauuu ucagcgcauu acccucuacc ugaugggcaa gaaguauucc      480

ccgugcgccu gggagguugu gagagcugaa aucaugcgga gcuucucuuu uuccacaaau      540

cugcagaaag ggcuccgcag aaaggauuga                                       570


<210>  4048
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA36042

<400>  4048
auggcacuaa gcuuuagcuu acuaauggca guacuaguac uaucauacaa aaguauaugc       60

ucauuaggau gcgaucuacc acaaacacac ucacuaggaa acagaagagc acuaauacua      120

uuagcacaaa ugggacgaau aagccauuuc ucaugcuuaa aagauagaua ugacuuugga      180

uuuccacaag aaguauucga uggaaaucaa uuucaaaaag cacaagcaau aagugcauuc      240

caugaaauga uacaacaaac auucaaucua uuuagcacaa aagauagcuc agcagcaugg      300

gaugaaacac uauuagacaa auucuauaua gaacucuucc aacaacuaaa ugacuuagaa      360

gcaugcguaa cacaagaagu aggaguagaa gaaauagcac uaaugaacga agacucaaua      420

uuagcaguaa gaaaauacuu ucaaagaaua acauuauauc uaaugggaaa aaaauauagc      480

ccaugcgcau gggaagucgu aagagcagaa auaaugagaa gcuuuagcuu uagcacaaac      540

uuacaaaaag gcuuaagaag aaaagauuaa                                       570


<210>  4049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__P32881

<400>  4049

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  4050
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAA52716

<400>  4050
auggccuuga cuuuuuauuu acuggucgcc cuaguggugc ucagcuacaa gucauucagc       60

ucucugggcu gugaucugcc ucagacucac agccugggua acaggagggc cuugauacuc      120

cuggcacaaa ugcgaagaau cucuccuuuc uccugccuga aggacagaca ugacuuugaa      180

uucccccagg aggaguuuga ugauaaacag uuccagaagg cucaagccau cucuguccuc      240

caugagauga uccagcagac cuucaaccuc uucagcacaa aggacucauc ugcugcuuug      300

gaugagaccc uucuagauga auucuacauc gaacuugacc agcagcugaa ugaccuggag      360

uccuguguga ugcaggaagu gggggugaua gagucucccc ugauguacga ggacuccauc      420

cuggcuguga ggaaauacuu ccaaagaauc acucuauauc ugacagagaa gaaauacagc      480

ucuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuu aucaaucaac      540

uugcaaaaaa gauugaagag uaaggaauga                                       570


<210>  4051
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4051
auggcccuga ccuucuaccu ccugguggcc cuggucgugc ucagcuacaa guccuucagc       60

ucccugggcu gcgaccugcc ccagacccac agccucggga accgccgggc gcugauccug      120

cucgcccaga ugcgccggau cuccccguuc agcugccuga aggaccgcca cgacuucgag      180

uucccccagg aggaguucga cgacaagcag uuccagaagg cccaggccau cuccgugcug      240

cacgagauga uccagcagac guucaaccuc uucagcacca aggacuccag cgccgcgcug      300

gacgagaccc ugcucgacga guucuacauc gagcuggacc agcagcugaa cgaccucgag      360

uccugcguca ugcaggaggu gggcgugauc gagagccccc ugauguacga ggacuccauc      420

cuggccgucc ggaaguacuu ccagcgcauc acccucuacc ugacggagaa gaaguacagc      480

uccugcgccu gggagguggu gcgggccgag aucaugcgca gcuucucccu gagcaucaac      540

cuccagaagc ggcugaaguc caaggaguga                                       570


<210>  4052
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4052
auggcccuca ccuucuaccu ccucgucgcc cucgucgucc ucuccuacaa guccuucucc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc ccucauccuc      120

cucgcccaga ugcgccgcau cucccccuuc uccugccuca aggaccgcca cgacuucgag      180

uucccccagg aggaguucga cgacaagcag uuccagaagg cccaggccau cuccguccuc      240

cacgagauga uccagcagac cuucaaccuc uucuccacca aggacuccuc cgccgcccuc      300

gacgagaccc uccucgacga guucuacauc gagcucgacc agcagcucaa cgaccucgag      360

uccugcguca ugcaggaggu cggcgucauc gagucccccc ucauguacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaccgagaa gaaguacucc      480

uccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucucccu cuccaucaac      540

cuccagaagc gccucaaguc caaggaguga                                       570


<210>  4053
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4053
auggcccuga ccuucuaccu ccuuguggcu cuggucguuu ugagcuauaa guccuuuucu       60

ucauuaggcu gcgaccugcc ccagacacac agucuaggga acagaagggc acucauccug      120

cuugcccaaa ugcggcgcau uagcccuuuc uccugucuga aagaucgaca ugacuuugag      180

uucccacagg aagaguuuga ugacaagcag uuccagaaag cgcaagcuau aucuguguug      240

cacgaaauga uccagcagac uuuuaaucuc uucucgacga aggauucaag cgccgcacug      300

gacgagaccc ugcucgauga auuuuacauu gaguuagacc agcaacugaa cgaucuugag      360

aguugcguaa ugcaggaagu gggagucauc gaguccccgu ugauguauga agacucuauu      420

cuggccgugc guaaauacuu ccagagaauc acacuauauc ucacugagaa gaaguacagc      480

uccugugcuu gggagguugu gagggcagaa auaaugcggu cauuuagucu gagcaucaau      540

cuucagaaac gccugaaguc uaaagaguga                                       570


<210>  4054
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4054
auggcccuga ccuucuaccu gcugguggcc cugguggugc ugagcuacaa gagcuucagc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc ccugauccug      120

cuggcccaga ugagaagaau cagccccuuc agcugccuga aggacagaca cgacuucgag      180

uucccccagg aggaguucga cgacaagcag uuccagaagg cccaggccau cagcgugcug      240

cacgagauga uccagcagac cuucaaccug uucagcacca aggacagcag cgccgcccug      300

gacgagaccc ugcuggacga guucuacauc gagcuggacc agcagcugaa cgaccuggag      360

agcugcguga ugcaggaggu gggcgugauc gagagccccc ugauguacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaccgagaa gaaguacagc      480

agcugcgccu gggagguggu gagagccgag aucaugagaa gcuucagccu gagcaucaac      540

cugcagaaga gacugaagag caaggaguga                                       570


<210>  4055
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4055
auggcccuga ccuucuaccu ccugguggcu cuugucguuc ugagcuauaa guccuuuucu       60

agccucggcu gcgaccugcc ccagacacac ucccuuggga acagacgggc ccugauccuc      120

cuggcgcaaa ugcgcagaau uucuccuuuc agcugucuga aagaucggca ugacuuugag      180

uucccgcagg aagaguuuga ugacaagcag uuccagaaag cucaagccau cuccgugcuc      240

cacgaaauga uucagcagac guuuaaucug uucucuacca aggauagcuc cgccgcucuu      300

gacgagacac ugcucgauga auuuuacauc gagcuggacc agcaacuuaa cgaucuggag      360

agcugcguga ugcaggaagu cggagugauu gagucucccc ucauguauga agacuccauc      420

cuggccguuc gcaaauacuu ccagagaauc acccuguauc ucacagagaa gaaguacagc      480

ucuugugcuu gggagguggu ccgggccgaa auuaugcgcu ccuuuagccu gucuaucaau      540

cuucagaaaa gacugaaguc caaagaguga                                       570


<210>  4056
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAA52716

<400>  4056
auggcacuaa ccuucuacuu acuaguagcc cuaguaguac uaucauacaa aucauuuuca       60

ucacuaggau gcgaccuccc acaaacacac ucacuaggaa acagaagagc acucauacua      120

cuagcacaaa ugcgaagaau aucaccauuc ucaugccuaa aagacagaca cgacuucgaa      180

uucccacaag aagaauucga cgacaaacaa uuccaaaaag cacaagcaau auccguacua      240

cacgaaauga uacaacaaac auucaaccua uucucaacaa aagacucauc agcagcacua      300

gacgaaacac uacuagacga auucuacaua gaacuagacc aacaacucaa cgacuuagaa      360

ucaugcguaa ugcaagaagu aggcguaauc gaaucaccac uaauguacga agacuccaua      420

cuagcaguaa gaaaauacuu ucaacgaaua acacuauacc uaacagaaaa aaaauacuca      480

ucaugcgcau gggaaguagu acgagcagaa auaaugagau cauucucauu aagcauaaac      540

uuacaaaaaa gacuaaaauc aaaagaauaa                                       570


<210>  4057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__Q14618

<400>  4057

Met Pro Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Trp Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  4058
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__CAA24970

<400>  4058
augccccugu ccuuuucuuu acugauggcc gugcuggugc ucagcuacaa auccaucugu       60

ucucugggcu gugaucugcc ucagacucac agccugggua auaggagggc cuggauacuc      120

cuggcacaaa ugggaagaau cucucauuuc uccugccuga aggacagaua ugauuucgga      180

uucccccagg agguguuuga uggcaaccag uuccagaagg cucaagccau cucugccuuc      240

caugagauga uccagcagac cuucaaucuc uucagcacaa aggauucuuc ugcugcuugg      300

gaugagaccc uccuagacaa auucuacauu gaacuuuucc agcaacugaa ugaccuagaa      360

gccuguguga cacaggaggu ugggguggaa gagauugccc ugaugaauga ggacuccauc      420

cuggcuguga ggaaauacuu ucaaagaauc acucuuuauc ugauggggaa gaaauacagc      480

ccuugugccu gggagguugu cagagcagaa aucaugagau ccuucucuuu uucaacaaac      540

uugcaaaaag gauuaagaag gaaggauuga                                       570


<210>  4059
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4059
augccccuga gcuucucccu ccugauggcc gugcuggucc ucagcuacaa guccaucugc       60

agccugggcu gcgaccugcc gcagacccac ucccucggga accgccgggc cuggauccug      120

cuggcgcaga ugggccgcau cagccacuuc uccugccuca aggaccggua cgacuucggg      180

uucccccagg agguguucga cggcaaccag uuccagaagg cccaggccau cagcgccuuc      240

cacgagauga uccagcagac cuucaaccug uucuccacga aggacagcuc cgccgcgugg      300

gacgagaccc ugcucgacaa guucuacauc gagcuguucc agcagcugaa cgaccucgag      360

gccugcguga cccaggaggu cgggguggag gagaucgccc ugaugaacga ggacagcauc      420

cuggccgugc gcaaguacuu ccagcggauc acccucuacc ugaugggcaa gaaguacucc      480

cccugcgcgu gggaggucgu gcgcgccgag aucaugcgga gcuucuccuu cagcacgaac      540

cugcagaagg gccuccgccg gaaggacuga                                       570


<210>  4060
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4060
augccccucu ccuucucccu ccucauggcc guccucgucc ucuccuacaa guccaucugc       60

ucccucggcu gcgaccuccc ccagacccac ucccucggca accgccgcgc cuggauccuc      120

cucgcccaga ugggccgcau cucccacuuc uccugccuca aggaccgcua cgacuucggc      180

uucccccagg aggucuucga cggcaaccag uuccagaagg cccaggccau cuccgccuuc      240

cacgagauga uccagcagac cuucaaccuc uucuccacca aggacuccuc cgccgccugg      300

gacgagaccc uccucgacaa guucuacauc gagcucuucc agcagcucaa cgaccucgag      360

gccugcguca cccaggaggu cggcgucgag gagaucgccc ucaugaacga ggacuccauc      420

cucgccgucc gcaaguacuu ccagcgcauc acccucuacc ucaugggcaa gaaguacucc      480

cccugcgccu gggaggucgu ccgcgccgag aucaugcgcu ccuucuccuu cuccaccaac      540

cuccagaagg gccuccgccg caaggacuga                                       570


<210>  4061
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4061
augccccuga gcuucucccu ccuuauggcc gugcuggucu ugucuuacaa gucaaucugc       60

aguuuaggcu gugaccugcc ucagacccac agccuaggga acagaagggc uuggauucuc      120

cuggcacaaa ugggacggau aucccauuuu ucuugccuua aagaucgcua ugacuucggu      180

uuuccacagg agguuuucga uggcaaucag uuucagaagg cccaagcgau cucggcuuuc      240

cacgaaauga uucagcagac auuuaaccug uucucaacua aagacagcag ugccgcaugg      300

gaugagacgu ugcucgacaa guuuuacauc gaacuguucc agcaacugaa ugaucucgag      360

gccuguguga cccaggaagu agggguggag gagauugcuu uaaugaacga agacuccauc      420

cuggcagucc gaaaauauuu ucagcguaua acacuuuacu ugaugggaaa gaaguauucu      480

ccgugcgccu gggagguggu uagagcugaa aucaugagga gcuucuccuu uucaacuaau      540

cugcagaaag gccuacggcg caaggauuga                                       570


<210>  4062
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4062
augccccuga gcuucagccu gcugauggcc gugcuggugc ugagcuacaa gagcaucugc       60

agccugggcu gcgaccugcc ccagacccac agccugggca acagaagagc cuggauccug      120

cuggcccaga ugggcagaau cagccacuuc agcugccuga aggacagaua cgacuucggc      180

uucccccagg agguguucga cggcaaccag uuccagaagg cccaggccau cagcgccuuc      240

cacgagauga uccagcagac cuucaaccug uucagcacca aggacagcag cgccgccugg      300

gacgagaccc ugcuggacaa guucuacauc gagcuguucc agcagcugaa cgaccuggag      360

gccugcguga cccaggaggu gggcguggag gagaucgccc ugaugaacga ggacagcauc      420

cuggccguga gaaaguacuu ccagagaauc acccuguacc ugaugggcaa gaaguacagc      480

cccugcgccu gggagguggu gagagccgag aucaugagaa gcuucagcuu cagcaccaac      540

cugcagaagg gccugagaag aaaggacuga                                       570


<210>  4063
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4063
augccccuga gcuucucccu ccugauggcc gugcuugucc ugucuuacaa gagcaucugc       60

ucccucggcu gugaccugcc ucagacccac ucucuuggga acagacgggc uuggauucug      120

cucgcccaaa ugggacgcau cagccauuuu uccugccuga aagauagaua ugacuucggc      180

uuuccgcagg agguuuucga ugggaaucag uuucagaagg cgcaagcuau uucugccuuc      240

cacgaaauga uccagcagac auuuaaccug uucagcacga aagacuccag cgccgcuugg      300

gaugagaccc uccuggacaa guuuuacauu gaacuuuucc agcaacugaa ugaucucgag      360

gccuguguga cacaggaagu gggagucgag gagaucgcuc ugaugaacga agacucuauc      420

cuugccgugc ggaaauauuu ucagcgcauu acccuguacc ucaugggcaa gaaguauucc      480

cccugcgcgu gggagguugu gagagccgaa aucaugcgga gcuucucuuu uuccacaaau      540

cugcagaaag ggcugcgcag aaaggauuga                                       570


<210>  4064
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__CAA24970

<400>  4064
augccauuaa gcuuuaguuu acuaauggca guacuaguac uaucauacaa aagcauaugc       60

ucacuaggau gcgaucuacc acaaacacac ucacuaggaa acagacgagc auggauauua      120

cuagcacaaa ugggaagaau aagccauuuc ucaugccuaa aagauagaua ugacuuugga      180

uuuccacaag aaguauucga uggaaaucaa uuucaaaaag cacaagcaau aagcgcauuc      240

caugaaauga uacaacaaac auucaaucua uuuaguacaa aagacagcuc agcagcaugg      300

gaugaaacac uauuagacaa auucuauaua gaacuauuuc aacaacuaaa ugacuuagaa      360

gcaugcguaa cacaagaagu aggaguagaa gaaauagcac uaaugaacga agacucaaua      420

uuagcaguaa gaaaauacuu ucaaagaaua acacuauauu uaaugggaaa aaaauacagc      480

ccaugcgcau gggaaguagu aagagcagaa auaaugagaa gcuuuagcuu uagcacaaac      540

uuacaaaaag gauuaagaag aaaagauuaa                                       570


<210>  4065
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__Q86UP4

<400>  4065

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu 
1               5                   10                  15      


Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met 
            100                 105                 110         


Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Lys Glu 
                165     


<210>  4066
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNalpha__Homo_sapiens__AAP20099

<400>  4066
augugugacc uaccacaaac ccacagccug gguagcagga ggaccuugau gcuccuggcg       60

cagaugagga gaaucucucu uuucuccugc uugaaggaca gacaugacuu uggauuuccc      120

caggaggagu uuggcaacca guuccaaaag gcugaaacca ucccuguccu ccaugagaug      180

auccagcaga ucuucaaccu cuucagcaca aaagacucau cugcugcuug ggaugagacc      240

cuccuagaca aauucuacac ugaacucuac cagcagcuga augaccugga agccugugug      300

auacaggggg ugggggugac agagacuccc cugaugaagg aggacuccau ucuggcugug      360

aggaaauacu uccaaagaau cacucucuau cugaaagaga agaaauacag cccuugugcc      420

ugggagguug ucagagcaga aaucaugaga ucuuuuucuu ugucaacaaa cuugcaagaa      480

aguuuaagau cuaaagagua a                                                501


<210>  4067
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4067
augugcgacc ugccccagac ccacagccuc ggcucccgcc ggacccugau gcugcucgcc       60

cagaugcgcc ggaucagccu guucuccugc cugaaggacc gccacgacuu cggguucccg      120

caggaggagu ucggcaacca guuccagaag gccgagacca uccccgugcu ccacgagaug      180

auccagcaga ucuucaaccu guucagcacc aaggacucca gcgcggccug ggacgagacc      240

cugcucgaca aguucuacac cgagcuguac cagcagcuga acgaccucga ggccugcguc      300

auccaggggg ugggcgugac ggagacgccc cugaugaagg aggacuccau ccuggccguc      360

cggaaguacu uccagcgcau cacccucuac cugaaggaga agaaguacag ccccugcgcc      420

ugggaggugg ugcgggcgga gaucaugcgc uccuucagcc uguccaccaa ccuccaggag      480

agccugcggu ccaaggagug a                                                501


<210>  4068
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4068
augugcgacc ucccccagac ccacucccuc ggcucccgcc gcacccucau gcuccucgcc       60

cagaugcgcc gcaucucccu cuucuccugc cucaaggacc gccacgacuu cggcuucccc      120

caggaggagu ucggcaacca guuccagaag gccgagacca uccccguccu ccacgagaug      180

auccagcaga ucuucaaccu cuucuccacc aaggacuccu ccgccgccug ggacgagacc      240

cuccucgaca aguucuacac cgagcucuac cagcagcuca acgaccucga ggccugcguc      300

auccagggcg ucggcgucac cgagaccccc cucaugaagg aggacuccau ccucgccguc      360

cgcaaguacu uccagcgcau cacccucuac cucaaggaga agaaguacuc ccccugcgcc      420

ugggaggucg uccgcgccga gaucaugcgc uccuucuccc ucuccaccaa ccuccaggag      480

ucccuccgcu ccaaggagug a                                                501


<210>  4069
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4069
augugcgacc ugccccagac ccacagccuc ggcuccagaa ggacacuuau gcuguuggcc       60

caaaugcggc gcaucucuuu auucucaugu cugaaggauc gacaugacuu uggguucccu      120

caggaggaau uuggaaacca guuccagaaa gcugagacua uuccagugcu acacgaaaug      180

auacaacaga ucuuuaaucu cuucaguacg aaggauagcu ccgcagccug ggacgagacc      240

cugcuugaua aauuuuacac agaacuguau cagcaguuga acgaccucga ggcgugcguc      300

auucaaggug uuggcgugac ugagaccccg cugaugaagg aagauucuau ccuggcugua      360

cguaaauacu uccagagaau uacacucuau uuaaaggaga agaaauacuc gcccugugcc      420

ugggaagugg ucagggcaga gaucaugcgg ucauuuagcc ugaguaccaa ucuucaggag      480

uccuugcgcu cuaaggaaug a                                                501


<210>  4070
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4070
augugcgacc ugccccagac ccacagccug ggcagcagaa gaacccugau gcugcuggcc       60

cagaugagaa gaaucagccu guucagcugc cugaaggaca gacacgacuu cggcuucccc      120

caggaggagu ucggcaacca guuccagaag gccgagacca uccccgugcu gcacgagaug      180

auccagcaga ucuucaaccu guucagcacc aaggacagca gcgccgccug ggacgagacc      240

cugcuggaca aguucuacac cgagcuguac cagcagcuga acgaccugga ggccugcgug      300

auccagggcg ugggcgugac cgagaccccc cugaugaagg aggacagcau ccuggccgug      360

agaaaguacu uccagagaau cacccuguac cugaaggaga agaaguacag ccccugcgcc      420

ugggaggugg ugagagccga gaucaugaga agcuucagcc ugagcaccaa ccugcaggag      480

agccugagaa gcaaggagug a                                                501


<210>  4071
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4071
augugcgacc ugccccagac ccacagccuc ggcuccagac ggacacugau gcuucuggcc       60

caaaugcgca gaaucucucu cuucagcugu cugaaggauc ggcaugacuu uggguucccu      120

caggaggaau uuggaaacca guuccagaaa gcugagacga uuccggugcu ucacgaaaug      180

auccaacaga uuuuuaaucu guucuccacc aaggauucua gcgccgcgug ggacgagaca      240

cuccuggaua aauuuuacac cgaacuguau cagcagcuca acgaccugga ggcuugcguc      300

auccaaggcg uuggggugac agagacaccc cuuaugaagg aagauuccau ucuggccgug      360

cgcaaauacu uccagagaau cacccucuau cugaaggaga agaaauacuc uccuugugcc      420

ugggaagucg ugcgggcuga gaucaugcgc agcuuuuccc uuagcaccaa ucugcaggag      480

ucucucagau ccaaggaaug a                                                501


<210>  4072
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNalpha__Homo_sapiens__AAP20099

<400>  4072
augugcgacc uaccacaaac acacucacua ggaucaagaa gaacacuaau gcuacuagca       60

caaaugcgaa gaauaucauu auucucaugc cuaaaagaca gacacgacuu cggauuccca      120

caagaagaau ucggaaacca auuccaaaaa gcagaaacaa uaccaguacu acacgaaaug      180

auacaacaaa uauucaaccu auucucaaca aaagacucau cagccgcaug ggacgaaaca      240

cuacuagaca aauucuacac agaauuauac caacaacuaa acgacuuaga agcaugcgua      300

auacaaggag uaggagucac agaaacacca cuaaugaaag aagacucaau acuagcagua      360

agaaaauacu uccaaagaau aacacuauac cuaaaagaaa aaaaauacuc accaugcgca      420

ugggaaguag uaagagcaga aauaaugaga uccuucucac uaucaacaaa ccuacaagaa      480

ucacuaagau caaaagaaua a                                                501


<210>  4073
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNB__Homo_sapiens__P01574

<400>  4073

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  4074
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNB__Homo_sapiens__AAA36040

<400>  4074
augaccaaca agugucuccu ccaaauugcu cuccuguugu gcuucuccac uacagcucuu       60

uccaugagcu acaacuugcu uggauuccua caaagaagca gcaauuuuca gugucagaag      120

cuccuguggc aauugaaugg gaggcuugaa uacugccuca aggacaggau gaacuuugac      180

aucccugagg agauuaagca gcugcagcag uuccagaagg aggacgccgc auugaccauc      240

uaugagaugc uccagaacau cuuugcuauu uucagacaag auucaucuag cacuggcugg      300

aaugagacua uuguugagaa ccuccuggcu aaugucuauc aucagauaaa ccaucugaag      360

acaguccugg aagaaaaacu ggagaaagaa gauuucacca ggggaaaacu caugagcagu      420

cugcaccuga aaagauauua ugggaggauu cugcauuacc ugaaggccaa ggaguacagu      480

cacugugccu ggaccauagu cagaguggaa auccuaagga acuuuuacuu cauuaacaga      540

cuuacagguu accuccgaaa cuga                                             564


<210>  4075
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNB__Homo_sapiens__AAA36040

<400>  4075
augaccaaca agugccugcu ccagaucgcc cugcugcucu gcuucagcac cacggcccug       60

uccaugagcu acaaccugcu cggcuuccug cagcgcucca gcaacuucca gugccagaag      120

cugcucuggc agcugaacgg gcggcuggag uacugccuca aggaccgcau gaacuucgac      180

auccccgagg agaucaagca gcugcagcag uuccagaagg aggacgcggc ccugaccauc      240

uacgagaugc uccagaacau cuucgccauc uuccggcagg acuccagcuc caccggcugg      300

aacgagacca ucguggagaa ccugcuggcc aacgucuacc accagaucaa ccaccucaag      360

acggugcugg aggagaagcu ggagaaggag gacuucaccc gcgggaagcu caugagcucc      420

cugcaccuga agcgguacua cggccgcauc cuccacuacc ugaaggccaa ggaguacagc      480

cacugcgcgu ggaccaucgu gcgggucgag auccugcgca acuucuacuu caucaaccgg      540

cucaccgggu accugcgcaa cuga                                             564


<210>  4076
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNB__Homo_sapiens__AAA36040

<400>  4076
augaccaaca agugccuccu ccagaucgcc cuccuccucu gcuucuccac caccgcccuc       60

uccauguccu acaaccuccu cggcuuccuc cagcgcuccu ccaacuucca gugccagaag      120

cuccucuggc agcucaacgg ccgccucgag uacugccuca aggaccgcau gaacuucgac      180

auccccgagg agaucaagca gcuccagcag uuccagaagg aggacgccgc ccucaccauc      240

uacgagaugc uccagaacau cuucgccauc uuccgccagg acuccuccuc caccggcugg      300

aacgagacca ucgucgagaa ccuccucgcc aacgucuacc accagaucaa ccaccucaag      360

accguccucg aggagaagcu cgagaaggag gacuucaccc gcggcaagcu cauguccucc      420

cuccaccuca agcgcuacua cggccgcauc cuccacuacc ucaaggccaa ggaguacucc      480

cacugcgccu ggaccaucgu ccgcgucgag auccuccgca acuucuacuu caucaaccgc      540

cucaccggcu accuccgcaa cuga                                             564


<210>  4077
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNB__Homo_sapiens__AAA36040

<400>  4077
augaccaaca agugccugcu ccagaucgcc cuucuguugu guuucagcac aacugcuuua       60

uccaugucuu acaaucugcu aggcuuucuc caaagaucaa guaacuucca gugccagaaa      120

cugcuuuggc agcugaaugg gagguuggag uauugucuca aggaccggau gaacuuugau      180

auucccgaag agauaaaaca acugcagcag uuccagaagg aagacgcagc ccugacgauc      240

uacgagaugc uccaaaauau uuuugcgauc uuccgccagg auagcuccuc uaccggaugg      300

aacgaaacaa uuguggagaa uuuacuggcu aacgucuauc accagaucaa ucaucuuaaa      360

acuguuuugg aggaaaagcu ggagaaggaa gacuuuaccc gagguaaacu aaugucguca      420

cuccaccuga agcguuacua uggcagaaua cuucauuacc ugaaagccaa ggaguauagc      480

cacugcgcau ggacaaucgu gaggguagag auuuugcgga acuucuacuu uaucaaucgc      540

cucaccgggu accugagaaa cuga                                             564


<210>  4078
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNB__Homo_sapiens__AAA36040

<400>  4078
augaccaaca agugccugcu gcagaucgcc cugcugcugu gcuucagcac caccgcccug       60

agcaugagcu acaaccugcu gggcuuccug cagagaagca gcaacuucca gugccagaag      120

cugcuguggc agcugaacgg cagacuggag uacugccuga aggacagaau gaacuucgac      180

auccccgagg agaucaagca gcugcagcag uuccagaagg aggacgccgc ccugaccauc      240

uacgagaugc ugcagaacau cuucgccauc uucagacagg acagcagcag caccggcugg      300

aacgagacca ucguggagaa ccugcuggcc aacguguacc accagaucaa ccaccugaag      360

accgugcugg aggagaagcu ggagaaggag gacuucacca gaggcaagcu gaugagcagc      420

cugcaccuga agagauacua cggcagaauc cugcacuacc ugaaggccaa ggaguacagc      480

cacugcgccu ggaccaucgu gagaguggag auccugagaa acuucuacuu caucaacaga      540

cugaccggcu accugagaaa cuga                                             564


<210>  4079
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNB__Homo_sapiens__AAA36040

<400>  4079
augaccaaca agugccugcu ccagaucgcc cugcuucugu guuucagcac aacggcucuc       60

uccaugucuu acaaucugcu uggcuuucug caaagaagcu ccaacuucca gugccagaaa      120

cuccuguggc agcugaaugg gcggcucgag uauugucuga aggaccgcau gaacuuugau      180

auucccgaag agaucaaaca acuucagcag uuccagaagg aagacgccgc gcugaccauu      240

uacgagaugc uccaaaauau cuuugcuauu uucagacagg auucuagcuc cacaggaugg      300

aacgaaacca ucguggagaa ucugcuugcc aacgucuauc accagaucaa ucaucugaaa      360

acaguucucg aggaaaagcu ggagaaggaa gacuuuaccc ggggcaaacu gaugucuagc      420

cuccaccuga agcgcuacua ugggcggauu cuucauuacc ugaaagccaa ggaguauucc      480

cacugcgcuu ggacaaucgu gagaguggag auucuccgca acuucuacuu uaucaauaga      540

cugaccggau accuucggaa cuga                                             564


<210>  4080
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNB__Homo_sapiens__AAA36040

<400>  4080
augacaaaca aaugccuacu acaaauagca cuacuccuau gcuucuccac aacagcacua       60

ucaaugucau acaaccuacu aggauuccua caacgauccu caaacuucca augccaaaaa      120

cuacuauggc aacuaaacgg aagacuagaa uacugcuuaa aagaccgcau gaacuucgac      180

auaccagaag aaauaaaaca acuacaacaa uuccaaaaag aagacgcagc acuaaccaua      240

uacgaaaugc uacaaaacau auucgcaaua uuccgacaag acucaucauc aacaggaugg      300

aacgaaacaa uaguagaaaa ccuccuagca aacguauacc accaaauaaa ccacuuaaaa      360

acaguacuag aagaaaaauu agaaaaagaa gacuucacaa gaggaaaauu aaugucauca      420

cuacaccuaa aacgauacua uggaagaaua cuacacuacc uaaaagcaaa agaauacuca      480

cauugcgcau ggacaauagu acgaguagaa auacuaagaa acuucuacuu cauaaacaga      540

cuaacaggau accuacgaaa cuaa                                             564


<210>  4081
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNB__Homo_sapiens__Q15943

<400>  4081

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Cys Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Arg Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Val Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Arg Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Arg Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Asp Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Val Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  4082
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNB__Homo_sapiens__AAC41702

<400>  4082
augaccaaca agugucuccu ccaaauugcu cuccuguugu gcuucuccac gacagcucuu       60

uccaugagcu acaacuugcu uggauuccua caaagaagca gcaauuguca gugucagaag      120

cuccuguggc aauugaaugg gaggcuugaa uacugccuca aggacaggag gaacuuugac      180

aucccugagg agauuaagca gcugcagcag uuccagaagg aggacgccgc agugaccauc      240

uaugagaugc uccagaacau cuuugcuauu uucagacaag auucaucgag cacuggcugg      300

aaugagacua uuguugagaa ccuccuggcu aaugucuauc aucagagaaa ccaucugaag      360

acaguccugg aagaaaaacu ggagaaagaa gauuucacca ggggaaaacg caugagcagu      420

cugcaccuga aaagauauua ugggaggauu cugcauuacc ugaaggccaa ggaggacagu      480

cacugugccu ggaccauagu cagaguggaa auccuaagga acuuuuacgu cauuaacaga      540

cuuacagguu accuccgaaa cuga                                             564


<210>  4083
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNB__Homo_sapiens__AAC41702

<400>  4083
augaccaaca agugccugcu ccagaucgcc cugcugcucu gcuucagcac cacggcccug       60

uccaugagcu acaaccugcu cggcuuccug cagcgcucca gcaacugcca gugccagaag      120

cugcucuggc agcugaacgg gcggcuggag uacugccuca aggaccgccg gaacuucgac      180

auccccgagg agaucaagca gcugcagcag uuccagaagg aggacgcggc cgugaccauc      240

uacgagaugc ugcagaacau cuucgccauc uuccgccagg acuccagcuc caccggcugg      300

aacgagacca ucgucgagaa ccuccuggcc aacguguacc accagcggaa ccaccugaag      360

acggugcucg aggagaagcu ggagaaggag gacuucaccc gcgggaagcg gaugagcucc      420

cugcaccuca agcgcuacua cggccggauc cugcacuacc ugaaggccaa ggaggacagc      480

cacugcgcgu ggaccaucgu ccgcguggag auccuccgga acuucuacgu gaucaaccgc      540

cugaccgggu accugcggaa cuga                                             564


<210>  4084
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNB__Homo_sapiens__AAC41702

<400>  4084
augaccaaca agugccuccu ccagaucgcc cuccuccucu gcuucuccac caccgcccuc       60

uccauguccu acaaccuccu cggcuuccuc cagcgcuccu ccaacugcca gugccagaag      120

cuccucuggc agcucaacgg ccgccucgag uacugccuca aggaccgccg caacuucgac      180

auccccgagg agaucaagca gcuccagcag uuccagaagg aggacgccgc cgucaccauc      240

uacgagaugc uccagaacau cuucgccauc uuccgccagg acuccuccuc caccggcugg      300

aacgagacca ucgucgagaa ccuccucgcc aacgucuacc accagcgcaa ccaccucaag      360

accguccucg aggagaagcu cgagaaggag gacuucaccc gcggcaagcg cauguccucc      420

cuccaccuca agcgcuacua cggccgcauc cuccacuacc ucaaggccaa ggaggacucc      480

cacugcgccu ggaccaucgu ccgcgucgag auccuccgca acuucuacgu caucaaccgc      540

cucaccggcu accuccgcaa cuga                                             564


<210>  4085
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNB__Homo_sapiens__AAC41702

<400>  4085
augaccaaca agugccugcu ccagaucgcc cuucuguugu guuucagcac aacugcuuua       60

uccaugucuu acaaucugcu aggcuuucuc caaagaucaa guaacugcca gugucagaaa      120

cugcuuuggc agcugaaugg gagguuggag uauugccuca aggaccggcg caacuucgau      180

auucccgaag agauaaaaca acugcagcag uuucagaagg aagacgcagc cgugacgauc      240

uacgagaugc ugcaaaauau uuucgcgauc uuucgacagg auagcuccuc uaccggaugg      300

aacgaaacaa uugucgagaa ucucuuagcu aacguuuauc accagcguaa ucaucugaaa      360

acugugcuug aggaaaaguu ggagaaggaa gacuucacca gagguaaaag gaugucguca      420

cugcaccuaa agcgguacua uggccgcauc cuccauuacc ugaaagccaa ggaggauagc      480

cacugugcau ggacaauagu aagaguggag auccuuagga acuuuuaugu cauuaaucgg      540

cugaccgggu acuugcgcaa cuga                                             564


<210>  4086
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNB__Homo_sapiens__AAC41702

<400>  4086
augaccaaca agugccugcu gcagaucgcc cugcugcugu gcuucagcac caccgcccug       60

agcaugagcu acaaccugcu gggcuuccug cagagaagca gcaacugcca gugccagaag      120

cugcuguggc agcugaacgg cagacuggag uacugccuga aggacagaag aaacuucgac      180

auccccgagg agaucaagca gcugcagcag uuccagaagg aggacgccgc cgugaccauc      240

uacgagaugc ugcagaacau cuucgccauc uucagacagg acagcagcag caccggcugg      300

aacgagacca ucguggagaa ccugcuggcc aacguguacc accagagaaa ccaccugaag      360

accgugcugg aggagaagcu ggagaaggag gacuucacca gaggcaagag aaugagcagc      420

cugcaccuga agagauacua cggcagaauc cugcacuacc ugaaggccaa ggaggacagc      480

cacugcgccu ggaccaucgu gagaguggag auccugagaa acuucuacgu gaucaacaga      540

cugaccggcu accugagaaa cuga                                             564


<210>  4087
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNB__Homo_sapiens__AAC41702

<400>  4087
augaccaaca agugccugcu ccagaucgcc cugcuucugu guuucagcac aacggcucuc       60

uccaugucuu acaaucugcu uggcuuucug caaagaagcu ccaacugcca gugucagaaa      120

cuccuguggc agcugaaugg gcggcucgag uauugccuga aggaccgcag aaacuucgau      180

auucccgaag agaucaaaca acuucagcag uuucagaagg aagacgccgc ggugaccauu      240

uacgagaugc ugcaaaauau cuucgcuauu uuucggcagg auucuagcuc cacaggaugg      300

aacgaaacca ucgucgagaa ucuccuggcc aacguuuauc accagcgcaa ucaucuuaaa      360

acagugcugg aggaaaagcu cgagaaggaa gacuucacca gaggcaaacg gaugucuagc      420

cugcaccuga agcgcuacua ugggagaauc cuccauuacc ugaaagccaa ggaggauucc      480

cacugugcuu ggacaauugu gcgggucgag auccuucgca acuuuuaugu gauuaauaga      540

cugaccggau accuccggaa cuga                                             564


<210>  4088
<211>  564
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNB__Homo_sapiens__AAC41702

<400>  4088
augacaaaua aaugccuacu acaaauagca cuacuacuau gcuucuccac aaccgcacua       60

ucaaugucau acaaccuacu aggauuccuc caaagaucau caaacugcca augccaaaaa      120

cuacuauggc aacuaaacgg aagacuagaa uacugccuaa aagacagacg aaacuucgac      180

auaccagaag aaauaaaaca acuacaacaa uuccaaaaag aagacgcagc aguaacaauc      240

uacgaaaugc uacaaaacau auucgcaaua uucagacaag acucaucauc aacaggaugg      300

aacgaaacaa uaguagaaaa cuuacuagca aauguauacc accaaagaaa ccacuuaaaa      360

acaguacuag aagaaaaacu agaaaaagaa gacuucacaa gaggaaaaag aaugucauca      420

cuacaccuaa aaagauacua cggcagaaua cuacacuacc uaaaagcaaa agaagacuca      480

cacugcgcau ggacaauagu acgaguagaa auacuaagaa acuucuaugu aauaaacaga      540

cuaacaggau acuuaagaaa cuaa                                             564


<210>  4089
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__P01579

<400>  4089

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  4090
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__AAB59534

<400>  4090
augaaauaua caaguuauau cuuggcuuuu cagcucugca ucguuuuggg uucucuuggc       60

uguuacugcc aggacccaua uguaaaagaa gcagaaaacc uuaagaaaua uuuuaaugca      120

ggucauucag auguagcgga uaauggaacu cuuuucuuag gcauuuugaa gaauuggaaa      180

gaggagagug acagaaaaau aaugcagagc caaauugucu ccuuuuacuu caaacuuuuu      240

aaaaacuuua aagaugacca gagcauccaa aagagugugg agaccaucaa ggaagacaug      300

aaugucaagu uuuucaauag caacaaaaag aaacgagaug acuucgaaaa gcugacuaau      360

uauucgguaa cugacuugaa uguccaacgc aaagcaauac augaacucau ccaagugaug      420

gcugaacugu cgccagcagc uaaaacaggg aagcgaaaaa ggagucagau gcuguuucga      480

ggucgaagag caucccagua a                                                501


<210>  4091
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__AAB59534

<400>  4091
augaaguaca ccagcuacau ccucgccuuc cagcucugca ucgugcuggg cucccugggg       60

ugcuacugcc aggaccccua cgucaaggag gccgagaacc ucaagaagua cuucaacgcg      120

ggccacagcg acguggccga caacgggacc cuguuccugg gcauccucaa gaacuggaag      180

gaggaguccg accgcaagau caugcagagc cagaucgugu ccuucuacuu caagcuguuc      240

aagaacuuca aggacgacca gagcauccag aaguccgucg agacgaucaa ggaggacaug      300

aacgugaagu ucuucaacag caacaagaag aagcgggacg acuucgagaa gcugaccaac      360

uacuccguga ccgaccucaa cguccagcgc aaggccaucc acgagcugau ccaggugaug      420

gccgagcuga gcccggccgc gaagaccggg aagcggaagc gcucccagau gcuguuccgg      480

ggccgccggg ccagccagug a                                                501


<210>  4092
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__AAB59534

<400>  4092
augaaguaca ccuccuacau ccucgccuuc cagcucugca ucguccucgg cucccucggc       60

ugcuacugcc aggaccccua cgucaaggag gccgagaacc ucaagaagua cuucaacgcc      120

ggccacuccg acgucgccga caacggcacc cucuuccucg gcauccucaa gaacuggaag      180

gaggaguccg accgcaagau caugcagucc cagaucgucu ccuucuacuu caagcucuuc      240

aagaacuuca aggacgacca guccauccag aaguccgucg agaccaucaa ggaggacaug      300

aacgucaagu ucuucaacuc caacaagaag aagcgcgacg acuucgagaa gcucaccaac      360

uacuccguca ccgaccucaa cguccagcgc aaggccaucc acgagcucau ccaggucaug      420

gccgagcucu cccccgccgc caagaccggc aagcgcaagc gcucccagau gcucuuccgc      480

ggccgccgcg ccucccagug a                                                501


<210>  4093
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__AAB59534

<400>  4093
augaaguaca ccagcuauau ccucgccuuc cagcucugca uugugcuugg cucccugggg       60

uguuacugcc aagaccccua ugucaaagag gcugaaaacu ugaagaaaua cuuuaaugca      120

ggacacucug auguugccga caacgguaca uuauuccugg gcauacuaaa gaauuggaaa      180

gaggaaucag auagaaagau caugcagagu cagauuguga gcuuuuauuu caagcucuuu      240

aaaaacuuca aggacgauca guccauccaa aaaucuguag agacuauuaa ggaagacaug      300

aaugugaaau uuuucaacuc gaauaagaag aaaagggaug acuuugagaa gcugacgaac      360

uacucaguca ccgaucuuaa ugugcagcgg aaagcgaucc augagcugau acagguuaug      420

gcugaauuga gcccugccgc aaagacaggg aaacgcaagc gaagucagau gcuguuccgu      480

ggaagaaggg ccucccaaug a                                                501


<210>  4094
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__AAB59534

<400>  4094
augaaguaca ccagcuacau ccuggccuuc cagcugugca ucgugcuggg cagccugggc       60

ugcuacugcc aggaccccua cgugaaggag gccgagaacc ugaagaagua cuucaacgcc      120

ggccacagcg acguggccga caacggcacc cuguuccugg gcauccugaa gaacuggaag      180

gaggagagcg acagaaagau caugcagagc cagaucguga gcuucuacuu caagcuguuc      240

aagaacuuca aggacgacca gagcauccag aagagcgugg agaccaucaa ggaggacaug      300

aacgugaagu ucuucaacag caacaagaag aagagagacg acuucgagaa gcugaccaac      360

uacagcguga ccgaccugaa cgugcagaga aaggccaucc acgagcugau ccaggugaug      420

gccgagcuga gccccgccgc caagaccggc aagagaaaga gaagccagau gcuguucaga      480

ggcagaagag ccagccagug a                                                501


<210>  4095
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__AAB59534

<400>  4095
augaaguaca ccagcuauau ccuggccuuc cagcucugca uugugcuggg cucccuuggg       60

uguuacugcc aagaccccua ugucaaagag gcugaaaacc ugaagaaaua cuuuaaugcc      120

ggacacucug auguugcgga caacggcaca cucuuccugg ggauccuuaa gaauuggaaa      180

gaggaaagcg auagaaagau uaugcagucc cagaucgugu cuuuuuauuu caagcuguuu      240

aaaaacuuca aggacgauca gagcauucaa aaauccgugg agacgaucaa ggaagacaug      300

aaugucaaau uuuucaacuc uaauaagaag aaacgggaug acuuugagaa gcucaccaac      360

uacagcguga cagaucugaa uguucagcgc aaagcuaucc augagcugau ucaggugaug      420

gccgaacucu ccccugccgc uaagaccgga aaaagaaagc ggagccagau gcuguuccgc      480

ggcagacggg ccucucaaug a                                                501


<210>  4096
<211>  501
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__AAB59534

<400>  4096
augaaauaca caucauacau auuagcauuc caacuaugca uaguacuagg aucacuagga       60

ugcuacugcc aagacccaua cguaaaagaa gcagaaaacc uaaaaaaaua cuucaacgca      120

ggucacucag acguagcaga caacggaaca cuauuccuag gaauauuaaa aaacuggaaa      180

gaagaaucag acagaaaaau aaugcaauca caaauaguau cauucuacuu caaacuauuc      240

aaaaacuuca aagacgacca aucaauacaa aaaucaguag aaacaauaaa agaagacaug      300

aacguaaaau ucuucaacag caauaaaaaa aaaagagacg acuucgaaaa acuaacaaac      360

uacucaguaa cagaccuaaa cguacaaaga aaagcaauac acgaauuaau acaaguaaug      420

gcagaacuau caccagcagc aaaaacagga aaaagaaaaa gaucacaaau guuauucaga      480

ggaagaagag caagccaaua a                                                501


<210>  4097
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14609

<400>  4097

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
    130                 135                 140                 






<210>  4098
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__AAP20100

<400>  4098
augcaggacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcga aaaaggaguc agaugcuguu ucgaggucga      420

agagcauccc aguaa                                                       435


<210>  4099
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__AAP20100

<400>  4099
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcgg aagcgcuccc agaugcuguu ccggggccgc      420

cgggcgagcc aguga                                                       435


<210>  4100
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__AAP20100

<400>  4100
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcgc aagcgcuccc agaugcucuu ccgcggccgc      420

cgcgccuccc aguga                                                       435


<210>  4101
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__AAP20100

<400>  4101
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcgc aaacgaucac agaugcuguu ucguggcaga      420

agggcaagcc aguga                                                       435


<210>  4102
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__AAP20100

<400>  4102
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagaga aagagaagcc agaugcuguu cagaggcaga      420

agagccagcc aguga                                                       435


<210>  4103
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__AAP20100

<400>  4103
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagaga aaacggagcc agaugcucuu ucgcgggaga      420

cgggcuuccc aguga                                                       435


<210>  4104
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__AAP20100

<400>  4104
augcaagacc cauacguaaa agaagccgaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

agcgacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acagcaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacagc      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cagcaaaaac aggaaaaaga aaaagaucac aaaugcuauu cagaggaaga      420

agagcaucac aauaa                                                       435


<210>  4105
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14610

<400>  4105

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Lys Arg Ser Leu 
    130                 


<210>  4106
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44326

<400>  4106
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcga aaaaggaguc ucuag                      405


<210>  4107
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44326

<400>  4107
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcgg aagcgcuccc uguga                      405


<210>  4108
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44326

<400>  4108
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcgc aagcgcuccc ucuga                      405


<210>  4109
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44326

<400>  4109
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcgc aaacgaucac uguga                      405


<210>  4110
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44326

<400>  4110
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagaga aagagaagcc uguga                      405


<210>  4111
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44326

<400>  4111
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagaga aaacggagcc ucuga                      405


<210>  4112
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44326

<400>  4112
augcaagacc cauacguaaa agaagcagaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cagcaaaaac aggaaaaaga aaaagaucac uauaa                      405


<210>  4113
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14611

<400>  4113

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Lys Arg Ser 
    130             


<210>  4114
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44330

<400>  4114
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcga aaaaggaguu aa                         402


<210>  4115
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44330

<400>  4115
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcgg aagcgcuccu ga                         402


<210>  4116
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44330

<400>  4116
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcgc aagcgcuccu ga                         402


<210>  4117
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44330

<400>  4117
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcgc aaacgaucau ga                         402


<210>  4118
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44330

<400>  4118
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagaga aagagaagcu ga                         402


<210>  4119
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44330

<400>  4119
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagaga aaacggagcu ga                         402


<210>  4120
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44330

<400>  4120
augcaagacc cauacguaaa agaagcagaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaagcuucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cagcaaaaac aggaaaaaga aaaagaucau aa                         402


<210>  4121
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14612

<400>  4121

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Lys Arg Leu 
    130             


<210>  4122
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44331

<400>  4122
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcga aaaaggcucu ag                         402


<210>  4123
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44331

<400>  4123
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcgg aagcgccugu ga                         402


<210>  4124
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44331

<400>  4124
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcgc aagcgccucu ga                         402


<210>  4125
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44331

<400>  4125
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcgc aaacgacugu ga                         402


<210>  4126
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44331

<400>  4126
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagaga aagagacugu ga                         402


<210>  4127
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44331

<400>  4127
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagaga aaacggcucu ga                         402


<210>  4128
<211>  402
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44331

<400>  4128
augcaagacc cauacguaaa agaagcagaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg aucaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cagcaaaaac aggaaaaaga aaaagacuau aa                         402


<210>  4129
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14613

<400>  4129

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Leu 
    130 


<210>  4130
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44329

<400>  4130
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcuc uag                                   393


<210>  4131
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44329

<400>  4131
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcug uga                                   393


<210>  4132
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44329

<400>  4132
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcuc uga                                   393


<210>  4133
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44329

<400>  4133
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcug uga                                   393


<210>  4134
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44329

<400>  4134
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagcug uga                                   393


<210>  4135
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44329

<400>  4135
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagcuc uga                                   393


<210>  4136
<211>  393
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44329

<400>  4136
augcaagacc cauacguaaa agaagccgaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cucggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaucauucu auuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cagcaaaaac aggaaaacua uaa                                   393


<210>  4137
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14614

<400>  4137

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Leu 
        115                 120                 125 


<210>  4138
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44328

<400>  4138
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cacucuag                                                    378


<210>  4139
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44328

<400>  4139
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg cccuguga                                                    378


<210>  4140
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44328

<400>  4140
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg cccucuga                                                    378


<210>  4141
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44328

<400>  4141
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cucuguga                                                    378


<210>  4142
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44328

<400>  4142
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg cccuguga                                                    378


<210>  4143
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44328

<400>  4143
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug cccucuga                                                    378


<210>  4144
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44328

<400>  4144
augcaagacc cauacguaaa agaagcagaa aacuuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacucuuc cuaggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cucucaccag cacuauaa                                                    378


<210>  4145
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q14615

<400>  4145

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala 
        115                 120                 


<210>  4146
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__CAA44327

<400>  4146
augcaagacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cauaa                                                       375


<210>  4147
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__CAA44327

<400>  4147
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccuga                                                       375


<210>  4148
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__CAA44327

<400>  4148
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccuga                                                       375


<210>  4149
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__CAA44327

<400>  4149
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cuuga                                                       375


<210>  4150
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__CAA44327

<400>  4150
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccuga                                                       375


<210>  4151
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__CAA44327

<400>  4151
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccuga                                                       375


<210>  4152
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__CAA44327

<400>  4152
augcaagacc ccuacguaaa agaagcagaa aaccuaaaaa aauacuucaa cgcaggacac       60

agcgacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

agcgacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca guagaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acagcaacaa aaaaaaaaga gacgacuucg aaaaauuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag cauaa                                                       375


<210>  4153
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__Q8NHY9

<400>  4153

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Thr Arg Ser Gln Met Leu Phe Arg Gly Arg Arg Ala Ser Gln 
    130                 135                 140                 






<210>  4154
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNG__Homo_sapiens__AAM28885

<400>  4154
augcaggacc cauauguaaa agaagcagaa aaccuuaaga aauauuuuaa ugcaggucau       60

ucagauguag cggauaaugg aacucuuuuc uuaggcauuu ugaagaauug gaaagaggag      120

agugacagaa aaauaaugca gagccaaauu gucuccuuuu acuucaaacu uuuuaaaaac      180

uuuaaagaug accagagcau ccaaaagagu guggagacca ucaaggaaga caugaauguc      240

aaguuuuuca auagcaacaa aaagaaacga gaugacuucg aaaagcugac uaauuauucg      300

guaacugacu ugaaugucca acgcaaagca auacaugaac ucauccaagu gauggcugaa      360

cugucgccag cagcuaaaac agggaagcga acaaggaguc agaugcuguu ucgaggucga      420

agagcauccc aguaa                                                       435


<210>  4155
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNG__Homo_sapiens__AAM28885

<400>  4155
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgucg cggacaacgg gacccucuuc cugggcaucc ugaagaacug gaaggaggag      120

uccgaccgca agaucaugca gagccagauc guguccuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagucc guggagacca ucaaggagga caugaacguc      240

aaguucuuca acagcaacaa gaagaagcgg gacgacuucg agaagcucac gaacuacucc      300

gugaccgacc ugaacgugca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cugagcccgg ccgccaagac cgggaagcgg acccgcuccc agaugcuguu ccggggccgc      420

cgggcgagcc aguga                                                       435


<210>  4156
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNG__Homo_sapiens__AAM28885

<400>  4156
augcaggacc ccuacgucaa ggaggccgag aaccucaaga aguacuucaa cgccggccac       60

uccgacgucg ccgacaacgg cacccucuuc cucggcaucc ucaagaacug gaaggaggag      120

uccgaccgca agaucaugca gucccagauc gucuccuucu acuucaagcu cuucaagaac      180

uucaaggacg accaguccau ccagaagucc gucgagacca ucaaggagga caugaacguc      240

aaguucuuca acuccaacaa gaagaagcgc gacgacuucg agaagcucac caacuacucc      300

gucaccgacc ucaacgucca gcgcaaggcc auccacgagc ucauccaggu cauggccgag      360

cucucccccg ccgccaagac cggcaagcgc acccgcuccc agaugcucuu ccgcggccgc      420

cgcgccuccc aguga                                                       435


<210>  4157
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNG__Homo_sapiens__AAM28885

<400>  4157
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg cagacaacgg gacccucuuu cuuggaaucc ugaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagaua guuucauucu acuuuaaguu guucaagaac      180

uuuaaagacg aucagaguau ccaaaagagc guggagacaa uuaaagaaga caugaaugua      240

aaguucuuua acuccaauaa aaagaagagg gaugacuucg agaaauuaac uaacuauucu      300

gugacggauc ugaaugucca gcggaaggcc auccaugagc uaauucaggu gauggcggaa      360

cucucgccug cugccaaaac cgguaagcgc acacgaucac agaugcuguu ucguggcaga      420

agggcaagcc aguga                                                       435


<210>  4158
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNG__Homo_sapiens__AAM28885

<400>  4158
augcaggacc ccuacgugaa ggaggccgag aaccugaaga aguacuucaa cgccggccac       60

agcgacgugg ccgacaacgg cacccuguuc cugggcaucc ugaagaacug gaaggaggag      120

agcgacagaa agaucaugca gagccagauc gugagcuucu acuucaagcu guucaagaac      180

uucaaggacg accagagcau ccagaagagc guggagacca ucaaggagga caugaacgug      240

aaguucuuca acagcaacaa gaagaagaga gacgacuucg agaagcugac caacuacagc      300

gugaccgacc ugaacgugca gagaaaggcc auccacgagc ugauccaggu gauggccgag      360

cugagccccg ccgccaagac cggcaagaga accagaagcc agaugcuguu cagaggcaga      420

agagccagcc aguga                                                       435


<210>  4159
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNG__Homo_sapiens__AAM28885

<400>  4159
augcaggacc ccuacgugaa ggaggccgaa aaccugaaaa aguauuucaa ugcuggccac       60

agcgaugucg ccgacaacgg gacccucuuu cugggaaucc uuaaaaauug gaaggaggaa      120

uccgauagaa aaauuaugca aucucagauc guuagcuucu acuuuaagcu guucaagaac      180

uuuaaagacg aucaguccau ucagaagucu guggagacaa ucaaagaaga caugaaugug      240

aaguucuuua acagcaauaa aaagaagcgg gaugacuucg agaaacucac gaacuauucc      300

gucaccgauc ugaaugugca acgcaaggcg auucaugagc uuauccaggu uauggcugaa      360

cugucuccug ccgccaaaac aggcaagaga acccggagcc agaugcucuu ucgcgggaga      420

cgggcuuccc aguga                                                       435


<210>  4160
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNG__Homo_sapiens__AAM28885

<400>  4160
augcaagacc cauacguaaa agaagcagaa aaccuaaaaa aauacuucaa cgcaggacac       60

ucagacguag cagacaacgg aacacuauuc cuaggaauac uaaaaaacug gaaagaagaa      120

ucagacagaa aaauaaugca aucacaaaua guaucauucu acuucaaacu auucaaaaac      180

uucaaagacg accaaucaau acaaaaauca gucgaaacaa uaaaagaaga caugaacgua      240

aaauucuuca acucaaacaa aaaaaaaaga gacgacuucg aaaaacuaac aaacuacuca      300

guaacagacc uaaacguaca aagaaaagca auacacgaac uaauacaagu aauggcagaa      360

cuaucaccag ccgcaaaaac aggaaaaaga acaagaucac aaaugcuauu cagaggaaga      420

agagcaagcc aauaa                                                       435


<210>  4161
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IFNomega__Homo_sapiens__P05000

<400>  4161

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  4162
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IFNomega__Homo_sapiens__AAH69095

<400>  4162
auggcccucc uguucccucu acuggcagcc cuagugauga ccagcuauag cccuguugga       60

ucucugggcu gugaucugcc ucagaaccau ggccuacuua gcaggaacac cuuggugcuu      120

cugcaccaaa ugaggagaau cuccccuuuc uugugucuca aggacagaag agacuucagg      180

uucccccagg agaugguaaa agggagccag uugcagaagg cccaugucau gucuguccuc      240

caugagaugc ugcagcagau cuucagccuc uuccacacag agcgcuccuc ugcugccugg      300

aacaugaccc uccuagacca acuccacacu ggacuucauc agcaacugca acaccuggag      360

accugcuugc ugcagguagu gggagaagga gaaucugcug gggcaauuag cagcccugca      420

cugaccuuga ggagguacuu ccagggaauc cgugucuacc ugaaagagaa gaaauacagc      480

gacugugccu gggaaguugu cagaauggaa aucaugaaau ccuuguucuu aucaacaaac      540

augcaagaaa gacugagaag uaaagauaga gaccugggcu caucuuga                   588


<210>  4163
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4163
auggcccucc uguucccccu gcuggccgcg cucgugauga ccagcuacuc cccggucggc       60

agccuggggu gcgaccugcc ccagaaccac ggccuccugu cccgcaacac ccuggugcuc      120

cugcaccaga ugcggcgcau cagccccuuc cugugccuca aggaccggcg cgacuuccgg      180

uucccccagg agauggugaa ggggucccag cugcagaagg cccacgucau gagcgugcug      240

cacgagaugc uccagcagau cuucucccug uuccacacgg agcgcagcuc cgccgccugg      300

aacaugaccc ugcucgacca gcugcacacc ggccugcacc agcagcucca gcaccuggag      360

accugccugc uccagguggu cggggagggc gagagcgccg gcgcgaucuc cagcccggcc      420

cugacgcugc ggcgcuacuu ccaggggauc cggguguacc ucaaggagaa gaaguacucc      480

gacugcgccu gggagguggu ccgcauggag aucaugaagu cccuguuccu gagcaccaac      540

augcaggagc ggcuccgcag caaggaccgg gaccugggcu ccagcuga                   588


<210>  4164
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4164
auggcccucc ucuucccccu ccucgccgcc cucgucauga ccuccuacuc ccccgucggc       60

ucccucggcu gcgaccuccc ccagaaccac ggccuccucu cccgcaacac ccucguccuc      120

cuccaccaga ugcgccgcau cucccccuuc cucugccuca aggaccgccg cgacuuccgc      180

uucccccagg agauggucaa gggcucccag cuccagaagg cccacgucau guccguccuc      240

cacgagaugc uccagcagau cuucucccuc uuccacaccg agcgcuccuc cgccgccugg      300

aacaugaccc uccucgacca gcuccacacc ggccuccacc agcagcucca gcaccucgag      360

accugccucc uccaggucgu cggcgagggc gaguccgccg gcgccaucuc cucccccgcc      420

cucacccucc gccgcuacuu ccagggcauc cgcgucuacc ucaaggagaa gaaguacucc      480

gacugcgccu gggaggucgu ccgcauggag aucaugaagu cccucuuccu cuccaccaac      540

augcaggagc gccuccgcuc caaggaccgc gaccucggcu ccuccuga                   588


<210>  4165
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4165
auggcccucc uguucccccu ucuggcugca uuggugauga ccagcuacuc cccugucggc       60

ucuuuagggu gcgaccugcc acagaaccac ggacuacucu caagaaauac acugguucuu      120

cugcaucaaa ugaggcggau caguccguuu uugugucuca aggaucgccg agacuuccgu      180

uuuccccagg agauggugaa ggguagccag cugcagaagg cccacguaau guccgugcug      240

caugaaaugc uccaacagau uuucucuuua uuucacacug agagaucguc agcggcuugg      300

aacaugacgc ugcuugauca guugcauacc ggccugcacc agcaacuaca gcaccucgaa      360

acaugccugc uucaggucgu gggggaggga gaaagcgccg gcgcaauaag uuccccugcc      420

cugacuuuga ggcgguauuu ccaggguauc cgcguuuacc ucaaagagaa gaaauauucu      480

gacugugcuu gggagguggu cagaauggaa auuaugaaaa gccuguuuuu auccaccaau      540

augcaagaga ggcugcgguc aaaggaucgc gaccucggga guagcuga                   588


<210>  4166
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4166
auggcccugc uguucccccu gcuggccgcc cuggugauga ccagcuacag ccccgugggc       60

agccugggcu gcgaccugcc ccagaaccac ggccugcuga gcagaaacac ccuggugcug      120

cugcaccaga ugagaagaau cagccccuuc cugugccuga aggacagaag agacuucaga      180

uucccccagg agauggugaa gggcagccag cugcagaagg cccacgugau gagcgugcug      240

cacgagaugc ugcagcagau cuucagccug uuccacaccg agagaagcag cgccgccugg      300

aacaugaccc ugcuggacca gcugcacacc ggccugcacc agcagcugca gcaccuggag      360

accugccugc ugcagguggu gggcgagggc gagagcgccg gcgccaucag cagccccgcc      420

cugacccuga gaagauacuu ccagggcauc agaguguacc ugaaggagaa gaaguacagc      480

gacugcgccu gggagguggu gagaauggag aucaugaaga gccuguuccu gagcaccaac      540

augcaggaga gacugagaag caaggacaga gaccugggca gcagcuga                   588


<210>  4167
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4167
auggcccucc uguucccccu gcuugcugcc cuggugauga ccagcuacuc cccugucggc       60

ucucucgggu gcgaccugcc gcagaaccac ggacuucuga gcagaaauac acucguucug      120

cugcaucaaa ugcggcgcau cucccccuuu cucugucuga aggauagacg ggacuuccgc      180

uuuccucagg agauggugaa gggcucucag cuucagaagg cgcacgugau gagcguccug      240

caugaaaugc uccaacagau uuucucccug uuucacacgg agagaucuag cgcugccugg      300

aacaugaccc uucuggauca gcuccauaca gggcugcacc agcaacugca gcaccucgaa      360

accugccugc uucagguggu uggagagggc gaauccgccg gggcuaucag cucucccgcc      420

cugacacucc ggcgcuauuu ccagggaauu agaguguacc ugaaagagaa gaaauauucc      480

gacugugcuu gggaggucgu gcggauggaa aucaugaaaa gccuuuuucu gucuaccaau      540

augcaagagc gccucagauc caaggaucgg gaccugggca gcucuuga                   588


<210>  4168
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IFNomega__Homo_sapiens__AAH69095

<400>  4168
auggcacuac ucuucccacu acuagcagca uuagucauga caucauacuc accaguagga       60

ucacuaggau gcgaccuacc acaaaaccac ggauuacuaa gcagaaacac acuaguacua      120

cuacaccaaa ugagaagaau aucaccauuc cuaugcuuaa aagacagaag agacuucaga      180

uucccacaag aaaugguaaa aggaucacaa uuacaaaaag cacacguaau gucaguacua      240

cacgaaaugc uacaacaaau auucucacua uuccacacag aaagaucauc agccgcaugg      300

aacaugacac uauuagacca acuacacaca ggacuccacc aacaacuaca acaccuagaa      360

acaugccuac uacaaguagu aggcgaagga gaaucagcag gagcaauauc aucaccagca      420

cuaacacuaa gaagauacuu ccaaggaaua agaguauacc uaaaagaaaa aaaauacuca      480

gacugcgcau gggaaguagu aagaauggaa auaaugaaaa gccuauuccu cucaacaaac      540

augcaagaaa gacuacgcuc aaaagauaga gacuuaggau caucauaa                   588


<210>  4169
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-10__Homo_sapiens__P22301

<400>  4169

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  4170
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-10__Homo_sapiens__AAA63207

<400>  4170
augcacagcu cagcacugcu cuguugccug guccuccuga cuggggugag ggccagccca       60

ggccagggca cccagucuga gaacagcugc acccacuucc caggcaaccu gccuaacaug      120

cuucgagauc uccgagaugc cuucagcaga gugaagacuu ucuuucaaau gaaggaucag      180

cuggacaacu uguuguuaaa ggaguccuug cuggaggacu uuaaggguua ccuggguugc      240

caagccuugu cugagaugau ccaguuuuac cuggaggagg ugaugcccca agcugagaac      300

caagacccag acaucaaggc gcaugugaac ucccuggggg agaaccugaa gacccucagg      360

cugaggcuac ggcgcuguca ucgauuucuu cccugugaaa acaagagcaa ggccguggag      420

caggugaaga augccuuuaa uaagcuccaa gagaaaggca ucuacaaagc caugagugag      480

uuugacaucu ucaucaacua cauagaagcc uacaugacaa ugaagauacg aaacuga         537


<210>  4171
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-10__Homo_sapiens__AAA63207

<400>  4171
augcacagcu ccgcccugcu cugcugccug gugcugcuca ccggcgugcg cgccagcccc       60

gggcagggca cccaguccga gaacagcugc acgcacuucc cggggaaccu gcccaacaug      120

cugcgggacc uccgcgacgc guucucccgg gugaagaccu ucuuccagau gaaggaccag      180

cuggacaacc ugcuccugaa ggagagccug cucgaggacu ucaagggcua ccuggggugc      240

caggcccugu ccgagaugau ccaguucuac cucgaggagg ugaugcccca ggccgagaac      300

caggaccccg acaucaaggc ccacgucaac agccugggcg agaaccugaa gacccuccgc      360

cugcggcugc gccggugcca ccgcuuccuc ccgugcgaga acaaguccaa ggccguggag      420

caggucaaga acgcguucaa caagcugcag gagaagggca ucuacaaggc caugagcgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagauccg gaacuga         537


<210>  4172
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-10__Homo_sapiens__AAA63207

<400>  4172
augcacuccu ccgcccuccu cugcugccuc guccuccuca ccggcguccg cgccuccccc       60

ggccagggca cccaguccga gaacuccugc acccacuucc ccggcaaccu ccccaacaug      120

cuccgcgacc uccgcgacgc cuucucccgc gucaagaccu ucuuccagau gaaggaccag      180

cucgacaacc uccuccucaa ggagucccuc cucgaggacu ucaagggcua ccucggcugc      240

caggcccucu ccgagaugau ccaguucuac cucgaggagg ucaugcccca ggccgagaac      300

caggaccccg acaucaaggc ccacgucaac ucccucggcg agaaccucaa gacccuccgc      360

cuccgccucc gccgcugcca ccgcuuccuc cccugcgaga acaaguccaa ggccgucgag      420

caggucaaga acgccuucaa caagcuccag gagaagggca ucuacaaggc cauguccgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagauccg caacuga         537


<210>  4173
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-10__Homo_sapiens__AAA63207

<400>  4173
augcacagcu ccgcccugcu cugcugucuu gugcuguuga ccggcgucag agcuucuccc       60

gggcagggaa cacaaucaga gaacaguugc acucauuucc cugguaauuu accaaacaug      120

cugagggacc uacgggaugc auuuagccgc guuaagacgu ucuuucagau gaaagaccag      180

cucgauaauc ugcuucugaa ggaauccuug cucgaggacu ucaaaggcua ccuggggugu      240

caggcccugu cugaaaugau ccaauuuuau cucgaggaag ugaugccgca ggcggagaac      300

caggaucccg acauuaaggc ucacguaaau ucguuaggag agaaccugaa aacccuucga      360

uugcgucuga gaaggugcca ucgguuccua ccuugugaaa auaagucaaa ggccguggag      420

caggucaaaa acgcauuuaa uaagcuccaa gaaaaaggca uauacaaggc caugagcgag      480

uucgauaucu uuauuaacua uaucgaggcu uacaugacaa ugaaaauucg caauuga         537


<210>  4174
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-10__Homo_sapiens__AAA63207

<400>  4174
augcacagca gcgcccugcu gugcugccug gugcugcuga ccggcgugag agccagcccc       60

ggccagggca cccagagcga gaacagcugc acccacuucc ccggcaaccu gcccaacaug      120

cugagagacc ugagagacgc cuucagcaga gugaagaccu ucuuccagau gaaggaccag      180

cuggacaacc ugcugcugaa ggagagccug cuggaggacu ucaagggcua ccugggcugc      240

caggcccuga gcgagaugau ccaguucuac cuggaggagg ugaugcccca ggccgagaac      300

caggaccccg acaucaaggc ccacgugaac agccugggcg agaaccugaa gacccugaga      360

cugagacuga gaagaugcca cagauuccug cccugcgaga acaagagcaa ggccguggag      420

caggugaaga acgccuucaa caagcugcag gagaagggca ucuacaaggc caugagcgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagaucag aaacuga         537


<210>  4175
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-10__Homo_sapiens__AAA63207

<400>  4175
augcacagcu ccgcccugcu cugcugucug gugcuucuga ccggcgucag agcuucuccc       60

gggcagggaa cacaaagcga gaacuccugc acgcauuucc cuggcaaucu cccgaacaug      120

cugcgggacc uucgcgaugc cuuuucuaga guuaagaccu ucuuucagau gaaagaccag      180

cuggauaauc uccugcugaa ggaaagccuc cuggaggacu ucaaagggua ccuuggaugu      240

caggcgcugu ccgaaaugau ccaauuuuau cucgaggaag ugaugcccca ggcugagaac      300

caggauccug acauuaaggc ccacgucaau ucucugggcg agaaccuuaa aacacugcgg      360

cuccgccuga gacggugcca ucgcuuccug cccugugaaa auaagagcaa ggccguggaa      420

caggugaaaa acgcuuuuaa uaagcuccaa gagaaaggga ucuacaaggc cauguccgag      480

uucgauauuu uuaucaacua uauugaggcu uacaugacca ugaaaaucag aaauuga         537


<210>  4176
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-10__Homo_sapiens__AAA63207

<400>  4176
augcacuccu cagcacuacu augcugccua guauuacuaa caggaguaag agcaucacca       60

ggacaaggaa cacaaucaga aaacucaugc acacacuucc caggaaaccu accaaacaug      120

cuaagagacc uaagagacgc auucucaaga guaaaaacau ucuuccaaau gaaagaccaa      180

cuagacaacu uacuacuaaa agaaucacua cuagaagacu ucaaaggaua ccuaggaugc      240

caagcacuau cagaaaugau acaauucuac cuagaagaag ucaugccaca agcagaaaac      300

caagacccag acauaaaagc acacguaaac ucacuaggag aaaacuuaaa aacauuaaga      360

cuaagacuaa gaagaugcca cagauuccua ccaugcgaaa acaaaucaaa agcaguagaa      420

caaguaaaaa acgcauucaa caaacuacaa gaaaaaggaa uauacaaagc aaugucagaa      480

uucgacauau ucauaaacua cauagaagca uacaugacaa ugaaaauaag aaacuaa         537


<210>  4177
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-11__Homo_sapiens__P20809

<400>  4177

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  4178
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-11__Homo_sapiens__AAA59132

<400>  4178
augaacugug uuugccgccu gguccugguc gugcugagcc uguggccaga uacagcuguc       60

gccccugggc caccaccugg ccccccucga guuuccccag acccucgggc cgagcuggac      120

agcaccgugc uccugacccg cucucuccug gcggacacgc ggcagcuggc ugcacagcug      180

agggacaaau ucccagcuga cggggaccac aaccuggauu cccugcccac ccuggccaug      240

agugcggggg cacugggagc ucuacagcuc ccaggugugc ugacaaggcu gcgagcggac      300

cuacuguccu accugcggca cgugcagugg cugcgccggg cagguggcuc uucccugaag      360

acccuggagc ccgagcuggg cacccugcag gcccgacugg accggcugcu gcgccggcug      420

cagcuccuga ugucccgccu ggcccugccc cagccacccc cggacccgcc ggcgcccccg      480

cuggcgcccc ccuccucagc cugggggggc aucagggccg cccacgccau ccuggggggg      540

cugcaccuga cacuugacug ggccgugagg ggacugcugc ugcugaagac ucggcuguga      600


<210>  4179
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-11__Homo_sapiens__AAA59132

<400>  4179
augaacugcg ugugccgccu gguccucgug gugcugagcc uguggcccga caccgccguc       60

gcccccgggc ccccgcccgg cccgccccgg gugucccccg acccccgcgc ggagcucgac      120

agcaccgugc ugcugacgcg gucccuccug gccgacaccc gccagcuggc cgcccagcuc      180

cgggacaagu uccccgccga cggcgaccac aaccuggaca gccugcccac ccucgcgaug      240

uccgccgggg cccugggcgc ccugcagcuc cccggggucc ugacccgccu gcgggcggac      300

cuccugagcu accugcgcca cgugcagugg cuccggcgcg ccggcggcuc cagccugaag      360

acgcuggagc ccgagcucgg gacccugcag gcccggcugg accgccuccu gcggcgccug      420

cagcuccuga ugucccggcu ggcccucccc cagcccccgc ccgacccgcc cgccccgccc      480

cuggcgccgc ccagcuccgc cuggggcggg auccgcgccg cccacgccau ccugggcggg      540

cuccaccuga cccuggacug ggcggugcgg ggccuccugc ugcucaagac ccgccuguga      600


<210>  4180
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-11__Homo_sapiens__AAA59132

<400>  4180
augaacugcg ucugccgccu cguccucguc guccucuccc ucuggcccga caccgccguc       60

gcccccggcc ccccccccgg ccccccccgc gucucccccg acccccgcgc cgagcucgac      120

uccaccgucc uccucacccg cucccuccuc gccgacaccc gccagcucgc cgcccagcuc      180

cgcgacaagu uccccgccga cggcgaccac aaccucgacu cccuccccac ccucgccaug      240

uccgccggcg cccucggcgc ccuccagcuc cccggcgucc ucacccgccu ccgcgccgac      300

cuccucuccu accuccgcca cguccagugg cuccgccgcg ccggcggcuc cucccucaag      360

acccucgagc ccgagcucgg cacccuccag gcccgccucg accgccuccu ccgccgccuc      420

cagcuccuca ugucccgccu cgcccucccc cagccccccc ccgacccccc cgcccccccc      480

cucgcccccc ccuccuccgc cuggggcggc auccgcgccg cccacgccau ccucggcggc      540

cuccaccuca cccucgacug ggccguccgc ggccuccucc uccucaagac ccgccucuga      600


<210>  4181
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-11__Homo_sapiens__AAA59132

<400>  4181
augaacugcg uguguagacu gguccucguu gugcuuagcc uguggcccga caccgccgua       60

gcuccuggcc caccgcccgg gccuccaagg gugucccccg auccucgggc agaguuggac      120

ucuacagucu uacugacucg cucacuacuc gccgauacgc gacagcuggc ggcucaacuu      180

cgugacaagu ucccagccga uggagaccac aaucuggaua guuugcccac ccucgcaaug      240

agcgccggug cucugggcgc acugcagcuc ccuggggugu uaacaagacu gagggccgac      300

cuuuuguccu accugcggca uguucagugg cuacgcagag cuggaggguc uucgcucaaa      360

acucuggaac cagagcuugg uacccugcag gccagguugg aucggcuccu gcgccgauua      420

caacugcuca ugucaagacu ugcgcugccg cagcccccuc cagauccccc ugcaccaccc      480

uuggccccgc cuagcagugc uuggggcgga aucagggccg cacacgcuau ucuaggcggc      540

cugcaucuca cacuggacug ggccgugcgg gggcuucugu ugcucaagac ccgucuguga      600


<210>  4182
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-11__Homo_sapiens__AAA59132

<400>  4182
augaacugcg ugugcagacu ggugcuggug gugcugagcc uguggcccga caccgccgug       60

gcccccggcc ccccccccgg cccccccaga gugagccccg accccagagc cgagcuggac      120

agcaccgugc ugcugaccag aagccugcug gccgacacca gacagcuggc cgcccagcug      180

agagacaagu uccccgccga cggcgaccac aaccuggaca gccugcccac ccuggccaug      240

agcgccggcg cccugggcgc ccugcagcug cccggcgugc ugaccagacu gagagccgac      300

cugcugagcu accugagaca cgugcagugg cugagaagag ccggcggcag cagccugaag      360

acccuggagc ccgagcuggg cacccugcag gccagacugg acagacugcu gagaagacug      420

cagcugcuga ugagcagacu ggcccugccc cagccccccc ccgacccccc cgcccccccc      480

cuggcccccc ccagcagcgc cuggggcggc aucagagccg cccacgccau ccugggcggc      540

cugcaccuga cccuggacug ggccgugaga ggccugcugc ugcugaagac cagacuguga      600


<210>  4183
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-11__Homo_sapiens__AAA59132

<400>  4183
augaacugcg uguguagacu gguccucguu gugcugagcc uuuggcccga caccgccgug       60

gcuccuggcc cgcccccugg gcccccucgg gucucccccg auccucgcgc cgagcuggac      120

ucuacagugc uccugacgag aagccuucug gcggauaccc ggcagcucgc ugcccaacug      180

cgcgacaagu ucccggccga uggagaccac aaucuggauu cccuccccac acuggcuaug      240

ucugccggcg cucuuggggc ccugcagcuc ccuggaguuc ugaccagacu ucgggcggac      300

cugcucagcu accugcgcca ugugcagugg cugagacggg ccggcggguc cucucucaaa      360

acacuggaac ccgagcuugg aacccugcag gcucgccucg auagacugcu ucggcgccug      420

caacuccuga ugagcagacu ggcccucccu cagcccccgc cugauccccc ugcuccuccc      480

cuggcgcccc cguccagcgc cuggggcggc auccgggccg cucacgccau ucuuggggga      540

cugcaucuca cacuggacug ggcuguccgc ggccuucugc uccugaagac cagacuguga      600


<210>  4184
<211>  600
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-11__Homo_sapiens__AAA59132

<400>  4184
augaacugug uauguagacu aguauuagua guauuaucau uauggccaga cacagcagua       60

gcaccaggac caccaccagg accaccaaga guaucaccag acccaagagc agaauuagac      120

ucaacaguuc ucuuaacaag aucuuuacua gcagacacaa gacaauuagc agcacaacua      180

agagacaaau ucccagcaga uggagaucau aauuuagaua guuuaccaac auuagcuaug      240

ucagcaggag cauuaggagc acuacaacua ccaggaguac uaacaagauu aagagcagac      300

uuauuaucau acuuaagaca uguacaaugg uuaagaagag caggaggauc aucucuaaaa      360

acacuagaac cagaacuagg aaccuuacaa gcaagauuag accgauuauu aagaagauua      420

caauuauuaa ugucaagauu agcauuacca caaccaccac cagauccacc agcaccacca      480

uuagcaccac caucuucagc auggggagga auaagagcag cacaugccau auuaggagga      540

cuacaccuaa cauuagacug ggcaguaaga ggacuacuac uacuaaaaac aagacuauaa      600


<210>  4185
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-12A__Homo_sapiens__P29459

<400>  4185

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  4186
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-12A__Homo_sapiens__AAK84425

<400>  4186
auguguccag cgcgcagccu ccuccuugug gcuacccugg uccuccugga ccaccucagu       60

uuggccagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac      120

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa      180

uuuuacccuu gcacuucuga agagauugau caugaagaua ucacaaaaga uaaaaccagc      240

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga      300

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug      360

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc      420

augaaugcaa agcuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug      480

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa      540

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau      600

gcuuucagaa uucgggcagu gacuauugau agagugauga gcuaucugaa ugcuuccuaa      660


<210>  4187
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4187
augugccccg cccgcagccu gcuccuggug gccacccugg uccuccugga ccaccugucc       60

cucgcgcgga accugccggu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc uccugcgcgc cguguccaac augcugcaga aggcccggca gacgcucgag      180

uucuacccgu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

acggucgagg ccugccugcc ccuggagcuc accaagaacg agagcugccu gaacucccgc      300

gagaccagcu ucaucaccaa cggguccugc cuggcgagcc ggaagacguc cuucaugaug      360

gcccucugcc ugagcuccau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcuccugau ggaccccaag cgccagaucu uccuggacca gaacaugcuc      480

gccgugaucg acgagcugau gcaggcgcug aacuucaaca gcgagaccgu cccccagaag      540

uccagccucg aggagccgga cuucuacaag accaagauca agcugugcau ccugcuccac      600

gccuuccgga uccgcgccgu gacgaucgac cgggugaugu ccuaccugaa cgccagcuga      660


<210>  4188
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4188
augugccccg cccgcucccu ccuccucguc gccacccucg uccuccucga ccaccucucc       60

cucgcccgca accuccccgu cgccaccccc gaccccggca uguuccccug ccuccaccac      120

ucccagaacc uccuccgcgc cgucuccaac augcuccaga aggcccgcca gacccucgag      180

uucuaccccu gcaccuccga ggagaucgac cacgaggaca ucaccaagga caagaccucc      240

accgucgagg ccugccuccc ccucgagcuc accaagaacg aguccugccu caacucccgc      300

gagaccuccu ucaucaccaa cggcuccugc cucgccuccc gcaagaccuc cuucaugaug      360

gcccucugcc ucuccuccau cuacgaggac cucaagaugu accaggucga guucaagacc      420

augaacgcca agcuccucau ggaccccaag cgccagaucu uccucgacca gaacaugcuc      480

gccgucaucg acgagcucau gcaggcccuc aacuucaacu ccgagaccgu cccccagaag      540

uccucccucg aggagcccga cuucuacaag accaagauca agcucugcau ccuccuccac      600

gccuuccgca uccgcgccgu caccaucgac cgcgucaugu ccuaccucaa cgccuccuga      660


<210>  4189
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4189
augugccccg ccagaagccu gcuccuugug gcuacccugg ucuuguuaga ccaccugucc       60

cuagcaagga accucccugu ugccacacca gauccgggca uguuccccug ucugcaucac      120

ucucagaauc uucugcgggc ggugucaaac auguugcaaa aggcucgcca gacucucgag      180

uuuuacccuu gcacgaguga agagaucgac caugaagaua uuaccaaaga caagacaagc      240

acuguagagg ccugucugcc acuggaacuc accaaaaaug aguccugcuu aaacucucga      300

gagacaucgu ucauaaccaa ugggucaugu cuggcaagcc guaagacaag uuuuaugaug      360

gcccuuugcu uguccucuau cuaugaagau cugaaaaugu accaggugga guucaagacu      420

augaacgcua agcuacucau ggaccccaaa agacagauuu uucuggauca aaauaugcuu      480

gcagucaucg acgaacugau gcaggccuug aacuucaaua gcgagaccgu gccucagaag      540

uccucacucg aggaaccaga uuuuuauaaa acgaagauua aacuguguau cuuacugcac      600

gcuuucagga uacgggccgu uacuaucgac cgcgugauga guuaccucaa cgcgagcuga      660


<210>  4190
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4190
augugccccg ccagaagccu gcugcuggug gccacccugg ugcugcugga ccaccugagc       60

cuggccagaa accugcccgu ggccaccccc gaccccggca uguuccccug ccugcaccac      120

agccagaacc ugcugagagc cgugagcaac augcugcaga aggccagaca gacccuggag      180

uucuaccccu gcaccagcga ggagaucgac cacgaggaca ucaccaagga caagaccagc      240

accguggagg ccugccugcc ccuggagcug accaagaacg agagcugccu gaacagcaga      300

gagaccagcu ucaucaccaa cggcagcugc cuggccagca gaaagaccag cuucaugaug      360

gcccugugcc ugagcagcau cuacgaggac cugaagaugu accaggugga guucaagacc      420

augaacgcca agcugcugau ggaccccaag agacagaucu uccuggacca gaacaugcug      480

gccgugaucg acgagcugau gcaggcccug aacuucaaca gcgagaccgu gccccagaag      540

agcagccugg aggagcccga cuucuacaag accaagauca agcugugcau ccugcugcac      600

gccuucagaa ucagagccgu gaccaucgac agagugauga gcuaccugaa cgccagcuga      660


<210>  4191
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4191
augugccccg ccagaagccu gcuccuggug gcuacccuug uccugcucga ccaccugucc       60

cuugcccgga accugccugu ugcgacaccg gaucccggca uguucccuug ucuccaucac      120

ucucagaauc ugcugcgcgc ugugagcaac augcuccaaa aggccagaca gacgcuggag      180

uuuuaccccu gcaccuccga agagaucgac caugaagaua uuacaaaaga caagaccucu      240

acaguggagg ccugucuucc ucuggaacuc accaaaaaug agagcugccu gaacucccgg      300

gagacaucuu ucaucaccaa ugggagcugu cuugcuuccc gcaagacgag cuuuaugaug      360

gcccugugcc ucucuuccau uuaugaagau cugaaaaugu accaggucga guucaagacc      420

augaacgcua agcugcucau ggaccccaaa agacagaucu uucuggauca aaauaugcuu      480

gccgugauug acgaacugau gcaggcgcuc aacuucaaua gcgagacagu uccucagaag      540

ucuucccugg aggaaccgga uuuuuauaaa accaagauca aacuuuguau ccugcuccac      600

gccuuccgga uucgcgcugu gacaaucgac agagucauga gcuaccugaa cgccucuuga      660


<210>  4192
<211>  660
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-12A__Homo_sapiens__AAK84425

<400>  4192
augugcccag caagaucacu acuacuagua gcaacacuag uacuacuaga ccaccuauca       60

cucgccagaa accucccagu agccacacca gacccaggaa uguuccccug ccuccaccau      120

ucccaaaacc uacuaagagc aguaucaaac augcuacaaa aagcaagaca aacacuagaa      180

uucuauccau gcacaucaga agaaauagac cacgaagaca uaacaaaaga caaaacauca      240

accguagaag caugccuccc acucgaacuc acaaaaaacg aaucaugccu aaacucaaga      300

gaaacaucau ucauaacaaa cggcucaugc uuagccucaa gaaaaacauc auucaugaug      360

gcacuaugcc ucucauccau auaugaagac uuaaaaaugu accaaguaga auuuaaaacc      420

augaacgcaa aauuacuaau ggacccaaaa agacaaauau uccuagacca aaacaugcua      480

gcaguaauag acgaacuaau gcaagcacua aacuucaacu cagaaaccgu accccaaaaa      540

ucaucucuag aagaaccaga cuucuacaaa acaaaaauaa aacuaugcau acuacuacac      600

gccuucagaa uaagagccgu cacaauagac agagucaugu cauaccuaaa cgccucauaa      660


<210>  4193
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-12__Homo_sapiens__P29460

<400>  4193

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  4194
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-12__Homo_sapiens__AAA35695

<400>  4194
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

ggcucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguuag                                          987


<210>  4195
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-12__Homo_sapiens__AAA35695

<400>  4195
augugccacc agcagcuggu gaucagcugg uucucccucg ucuuccuggc cagcccccug       60

guggccaucu gggagcucaa gaaggacgug uacgucgugg agcuggacug guacccggac      120

gcgcccggcg agaugguggu ccugaccugc gacacccccg aggaggacgg gaucacgugg      180

acccucgacc aguccagcga ggugcugggc uccgggaaga cccugaccau ccaggugaag      240

gaguucggcg acgccgggca guacacgugc cacaagggcg gcgagguccu cagccacucc      300

cugcugcucc ugcacaagaa ggaggacggg aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgguuc      420

acgugcuggu ggcugaccac caucagcacc gaccugaccu ucuccgucaa gagcucccgc      480

gggagcuccg acccgcaggg cgugacgugc ggggccgcca cccucagcgc ggagcgggug      540

cgcggcgaca acaaggagua cgaguacucc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agucccugcc caucgaggug auggucgacg cggugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucauccgg gacaucauca agcccgaccc gcccaagaac      720

cuccagcuga agccccugaa gaacucccgc cagguggagg ucagcuggga guaccccgac      780

accuggucca cgccgcacag cuacuucucc cucaccuucu gcguccaggu gcagggcaag      840

agcaagcggg agaagaagga ccgcguguuc accgacaaga ccuccgccac ggugaucugc      900

cggaagaacg ccagcaucuc cgugcgcgcc caggaccggu acuacagcuc cagcuggucc      960

gagugggcca gcguccccug cuccuga                                          987


<210>  4196
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-12__Homo_sapiens__AAA35695

<400>  4196
augugccacc agcagcucgu caucuccugg uucucccucg ucuuccucgc cuccccccuc       60

gucgccaucu gggagcucaa gaaggacguc uacgucgucg agcucgacug guaccccgac      120

gcccccggcg agauggucgu ccucaccugc gacacccccg aggaggacgg caucaccugg      180

acccucgacc aguccuccga gguccucggc uccggcaaga cccucaccau ccaggucaag      240

gaguucggcg acgccggcca guacaccugc cacaagggcg gcgagguccu cucccacucc      300

cuccuccucc uccacaagaa ggaggacggc aucuggucca ccgacauccu caaggaccag      360

aaggagccca agaacaagac cuuccuccgc ugcgaggcca agaacuacuc cggccgcuuc      420

accugcuggu ggcucaccac caucuccacc gaccucaccu ucuccgucaa guccucccgc      480

ggcuccuccg acccccaggg cgucaccugc ggcgccgcca cccucuccgc cgagcgcguc      540

cgcggcgaca acaaggagua cgaguacucc gucgagugcc aggaggacuc cgccugcccc      600

gccgccgagg agucccuccc caucgagguc auggucgacg ccguccacaa gcucaaguac      660

gagaacuaca ccuccuccuu cuucauccgc gacaucauca agcccgaccc ccccaagaac      720

cuccagcuca agccccucaa gaacucccgc caggucgagg ucuccuggga guaccccgac      780

accuggucca ccccccacuc cuacuucucc cucaccuucu gcguccaggu ccagggcaag      840

uccaagcgcg agaagaagga ccgcgucuuc accgacaaga ccuccgccac cgucaucugc      900

cgcaagaacg ccuccaucuc cguccgcgcc caggaccgcu acuacuccuc cuccuggucc      960

gagugggccu ccguccccug cuccuga                                          987


<210>  4197
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-12__Homo_sapiens__AAA35695

<400>  4197
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuugc cucuccccug       60

guugcuauuu gggaguugaa gaaagacgug uacguagugg aauuagauug guauccugac      120

gcaccaggcg agauggucgu gcugaccugu gauacaccgg aagaggacgg gauaacuugg      180

acgcuagauc agucaaguga aguucucgga agcgguaaga cccugacaau ccaggugaaa      240

gaguucggcg acgccgggca guacacuugc cauaagggag gcgagguccu uucccacucu      300

cuguugcucc ugcauaaaaa ggaagauggu auuuggucga ccgacauccu gaaggaucaa      360

aaagagccca agaacaaaac auuucucaga ugugaagcga agaauuauuc agggagguuu      420

accugcuggu gguuaacuac aauuagcacc gaccugacgu ucagugugaa auccucucgg      480

ggaagcuccg auccucaggg cguaacuugu ggcgcugcca cccuuucagc agagcgcguu      540

cgaggggaca acaaggagua cgaauauagu guggagugcc aggaagauag cgccugucca      600

gcugcagagg aaucuuugcc caucgagguc augguggacg ccgugcacaa gcugaaauac      660

gagaauuaua cauccucauu cuuuauacgu gacaucauua agccugaucc acccaaaaac      720

cuacagcuca agccucugaa aaauagcaga caagucgaag uuaguuggga guacccagac      780

acuuggucua ccccgcauuc cuacuucagc cuuacauuuu gcgugcaggu acagggaaag      840

ucgaaaaggg aaaagaagga ucggguguuc accgacaaaa cgucugcuac ugucaucugu      900

cgcaagaacg ccuccauuuc agugagagcg caggauaggu auuacaguag cuccuggucu      960

gagugggcaa gcguucccug cucauga                                          987


<210>  4198
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-12__Homo_sapiens__AAA35695

<400>  4198
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg agcuggacug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugc cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accugcuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gagcagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaggacag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gacaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagcaga cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu gcagggcaag      840

agcaagagag agaagaagga cagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caggacagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcuga                                          987


<210>  4199
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-12__Homo_sapiens__AAA35695

<400>  4199
augugccacc agcaacuggu gaucagcugg uucucccucg ucuuucuggc cucuccccuu       60

guugcuauuu gggagcugaa gaaagacgug uacguggucg aacucgauug guauccugac      120

gccccgggcg agaugguggu ucugaccugu gauacacccg aagaggacgg gaucacgugg      180

acccuugauc agagcuccga agugcuggga ucuggcaaga cacucaccau ucaggucaaa      240

gaguucgggg acgcgggaca guacacaugc cauaagggcg gggaggugcu gagccacucc      300

cugcuccugc uucauaaaaa ggaagaugga aucuggucua ccgacauucu gaaggaucaa      360

aaagagccua agaacaaaac auuucucaga ugugaagcua agaauuauag cggccgguuu      420

accugcuggu ggcugacgac caucuccaca gaccuuaccu ucagcguuaa aucuucccgc      480

ggcagcucug auccccaggg ggugacaugu ggagccgcca cccuguccgc ugagagaguc      540

cggggcgaca acaaggagua cgaauauagc guggagugcc aggaagauuc ugccuguccu      600

gcugccgagg aaucccuccc caucgaggug auggucgacg cgguucacaa gcugaaauac      660

gagaauuaua cgagcuccuu cuuuauucgc gacaucauua agccugaucc gcccaaaaac      720

cugcagcuca agccucugaa aaauucuaga caaguggaag ugagcuggga guaccccgac      780

acauggucca ccccucauag cuacuucucu cuuacauuuu gcguccaggu gcaggggaag      840

uccaaacggg aaaagaagga ucgcguuuuc accgacaaaa ccagcgccac agugaucugu      900

agaaagaacg cuucuauuag cguccgggcc caggaucgcu auuacuccuc uagcuggucc      960

gagugggcua gcgugcccug cucuuga                                          987


<210>  4200
<211>  987
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-12__Homo_sapiens__AAA35695

<400>  4200
augugccacc aacaacuagu aauaucaugg uucucacuag uauucuuggc aucaccccua       60

guagcaauau gggaacuaaa aaaagacgua uacguaguag aacuagacug guacccagac      120

gcaccaggag aaaugguagu auuaacaugc gacacaccag aagaagaugg aauaacuugg      180

acauuagacc aaucaaguga aguauuagga ucaggcaaaa cacuaacuau acaaguaaaa      240

gaauuuggag acgcaggaca auacaccugc cacaaaggag gcgaaguccu aucacauuca      300

cuacuauuau uacacaaaaa agaagacgga aucuggagca cagacauauu aaaagaccaa      360

aaagaaccaa aaaacaaaac auuucuaaga ugcgaagcua aaaacuauuc aggaagauuc      420

acaugcuggu ggcuaacaac caucaguacc gacuuaacau ucucaguaaa aucaucaaga      480

ggaucaucag acccacaagg aguaacaugu ggagcagcaa cacuaagcgc agaaagagua      540

cgaggagaca acaaagaaua cgaauauuca guagaauguc aagaagacuc agcaugcccu      600

gcagcagaag aaucauuacc aauagaagua auggucgacg cuguacacaa acuaaaauau      660

gaaaauuaca caagcaguuu cuucauaaga gacauaauaa aacccgaccc accaaaaaac      720

cuacaacuaa aaccauuaaa aaauucaaga caaguagaag uaucauggga auacccagau      780

acauggagca caccacacag uuacuucuca uuaacauucu gcguacaagu acaaggaaaa      840

aguaaaagag aaaaaaaaga cagaguauuc acagauaaga cuucagcaac aguaauaugc      900

agaaaaaacg caagcauaag cguacgagca caagacagau auuacucaag cucaugguca      960

gaaugggcau caguaccaug uucauaa                                          987


<210>  4201
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-13__Homo_sapiens__P35225

<400>  4201

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
    130                 135                 140                 


Phe Asn 
145     


<210>  4202
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-13__Homo_sapiens__CAA48823

<400>  4202
augcauccgc uccucaaucc ucuccuguug gcacugggcc ucauggcgcu uuuguugacc       60

acggucauug cucucacuug ccuuggcggc uuugccuccc caggcccugu gccucccucu      120

acagcccuca gggagcucau ugaggagcug gucaacauca cccagaacca gaaggcuccg      180

cucugcaaug gcagcauggu auggagcauc aaccugacag cuggcaugua cugugcagcc      240

cuggaauccc ugaucaacgu gucaggcugc agugccaucg agaagaccca gaggaugcug      300

agcggauucu gcccgcacaa ggucucagcu gggcaguuuu ccagcuugca uguccgagac      360

accaaaaucg agguggccca guuuguaaag gaccugcucu uacauuuaaa gaaacuuuuu      420

cgcgagggac gguucaacug a                                                441


<210>  4203
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-13__Homo_sapiens__CAA48823

<400>  4203
augcaccccc ugcucaaccc gcugcugcuc gcccugggcc ugauggcccu ccugcugacc       60

accgugaucg cgcucacgug ccucgggggc uucgccagcc ccgggcccgu gcccccgucc      120

accgcccugc gcgagcucau cgaggagcug gucaacauca cccagaacca gaaggcgccc      180

cugugcaacg gcagcauggu gugguccauc aaccucaccg ccgggaugua cugcgccgcc      240

cuggagagcc ugaucaacgu cuccggcugc agcgccaucg agaagacgca gcggaugcuc      300

uccggcuucu gcccccacaa ggugagcgcc gggcaguucu ccagccugca cgugcgcgac      360

accaagaucg aggucgcgca guucgugaag gaccugcucc ugcaccugaa gaagcuguuc      420

cgggagggcc gcuucaacug a                                                441


<210>  4204
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-13__Homo_sapiens__CAA48823

<400>  4204
augcaccccc uccucaaccc ccuccuccuc gcccucggcc ucauggcccu ccuccucacc       60

accgucaucg cccucaccug ccucggcggc uucgccuccc ccggccccgu cccccccucc      120

accgcccucc gcgagcucau cgaggagcuc gucaacauca cccagaacca gaaggccccc      180

cucugcaacg gcuccauggu cugguccauc aaccucaccg ccggcaugua cugcgccgcc      240

cucgaguccc ucaucaacgu cuccggcugc uccgccaucg agaagaccca gcgcaugcuc      300

uccggcuucu gcccccacaa ggucuccgcc ggccaguucu ccucccucca cguccgcgac      360

accaagaucg aggucgccca guucgucaag gaccuccucc uccaccucaa gaagcucuuc      420

cgcgagggcc gcuucaacug a                                                441


<210>  4205
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-13__Homo_sapiens__CAA48823

<400>  4205
augcaccccc ugcucaaccc ucuucuguug gccuuaggcc ugauggcucu acuccugacc       60

acagugaucg cacuuacuug ccuuggggga uucgccagcc cagguccggu ucccccuucc      120

acggcguuga gagagcucau ugaagaguug gucaauauaa cccagaacca aaaggcucca      180

cuguguaaug gcucuauggu guggucaauc aaccucacag ccgggaugua cugcgcagcc      240

uuagaaaguc ugauuaaugu aagcggaugu uccgcuaucg agaaaacuca gaggaugcuu      300

ucuggcuuuu gcccccauaa ggugucggca ggucaguucu caagccugca cguccgggac      360

accaaaauug aaguggccca guuuguuaag gaucugcuac uccaucugaa aaagcuguuc      420

cgcgaggggc gauuuaacug a                                                441


<210>  4206
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-13__Homo_sapiens__CAA48823

<400>  4206
augcaccccc ugcugaaccc ccugcugcug gcccugggcc ugauggcccu gcugcugacc       60

accgugaucg cccugaccug ccugggcggc uucgccagcc ccggccccgu gccccccagc      120

accgcccuga gagagcugau cgaggagcug gugaacauca cccagaacca gaaggccccc      180

cugugcaacg gcagcauggu guggagcauc aaccugaccg ccggcaugua cugcgccgcc      240

cuggagagcc ugaucaacgu gagcggcugc agcgccaucg agaagaccca gagaaugcug      300

agcggcuucu gcccccacaa ggugagcgcc ggccaguuca gcagccugca cgugagagac      360

accaagaucg agguggccca guucgugaag gaccugcugc ugcaccugaa gaagcuguuc      420

agagagggca gauucaacug a                                                441


<210>  4207
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-13__Homo_sapiens__CAA48823

<400>  4207
augcaccccc ugcucaaccc ucugcuucug gcccucggcc ugauggcccu ucugcucacc       60

acagugaucg cucugacgug ccuuggggga uucgcgagcc cgggccccgu cccucccucc      120

accgcucuca gagagcugau ugaggaacuu guuaauauca cacagaacca aaaggccccu      180

cuguguaaug ggucuauggu guggagcauu aaccucaccg ccggaaugua cugcgcugcc      240

cuggaauccc uuaucaaugu gucuggcugu agcgcuauug agaaaacaca gcggaugcug      300

uccggguuuu gcccccauaa ggucucugcc ggacaguuca gcucccucca cgugcgcgac      360

accaaaaucg aaguugcgca guuugugaag gaucugcugc uccaucugaa aaagcuguuc      420

agagagggcc gguuuaacug a                                                441


<210>  4208
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-13__Homo_sapiens__CAA48823

<400>  4208
augcacccac uacuaaaccc acuacuacua gcacuaggac uaauggcacu acuacuaaca       60

acaguaauag cacuaacaug ccuaggagga uucgcaucac caggaccagu accaccauca      120

acagcacuaa gagaacuaau agaagaacua guaaacauaa cacaaaacca aaaagcacca      180

cuaugcaacg gaucaauggu auggucaaua aaccuaacag caggaaugua cugcgcagca      240

cuagaaucac uaauaaacgu aucaggaugc ucagcaauag aaaaaacaca aagaaugcua      300

ucaggauucu gcccacacaa aguaucagca ggacaauucu caucacuaca cguaagagac      360

acaaaaauag aaguagcaca auucguaaaa gaccuacuac uacaccuaaa aaaacuauuc      420

cgagaaggaa gauucaacua a                                                441


<210>  4209
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-14__Homo_sapiens__P40222

<400>  4209

Met Lys Asn Gln Asp Lys Lys Asn Gly Ala Ala Lys Gln Ser Asn Pro 
1               5                   10                  15      


Lys Ser Ser Pro Gly Gln Pro Glu Ala Gly Pro Glu Gly Ala Gln Glu 
            20                  25                  30          


Arg Pro Ser Gln Ala Ala Pro Ala Val Glu Ala Glu Gly Pro Gly Ser 
        35                  40                  45              


Ser Gln Ala Pro Arg Lys Pro Glu Gly Ala Gln Ala Arg Thr Ala Gln 
    50                  55                  60                  


Ser Gly Ala Leu Arg Asp Val Ser Glu Glu Leu Ser Arg Gln Leu Glu 
65                  70                  75                  80  


Asp Ile Leu Ser Thr Tyr Cys Val Asp Asn Asn Gln Gly Gly Pro Gly 
                85                  90                  95      


Glu Asp Gly Ala Gln Gly Glu Pro Ala Glu Pro Glu Asp Ala Glu Lys 
            100                 105                 110         


Ser Arg Thr Tyr Val Ala Arg Asn Gly Glu Pro Glu Pro Thr Pro Val 
        115                 120                 125             


Val Asn Gly Glu Lys Glu Pro Ser Lys Gly Asp Pro Asn Thr Glu Glu 
    130                 135                 140                 


Ile Arg Gln Ser Asp Glu Val Gly Asp Arg Asp His Arg Arg Pro Gln 
145                 150                 155                 160 


Glu Lys Lys Lys Ala Lys Gly Leu Gly Lys Glu Ile Thr Leu Leu Met 
                165                 170                 175     


Gln Thr Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu 
            180                 185                 190         


Cys Lys Lys Tyr Ala Glu Leu Leu Glu Glu His Arg Asn Ser Gln Lys 
        195                 200                 205             


Gln Met Lys Leu Leu Gln Lys Lys Gln Ser Gln Leu Val Gln Glu Lys 
    210                 215                 220                 


Asp His Leu Arg Gly Glu His Ser Lys Ala Val Leu Ala Arg Ser Lys 
225                 230                 235                 240 


Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Arg Ser Leu Lys 
                245                 250                 255     


Glu Glu Gly Val Gln Arg Ala Arg Glu Glu Glu Glu Lys Arg Lys Glu 
            260                 265                 270         


Val Thr Ser His Phe Gln Val Thr Leu Asn Asp Ile Gln Leu Gln Met 
        275                 280                 285             


Glu Gln His Asn Glu Arg Asn Ser Lys Leu Arg Gln Glu Asn Met Glu 
    290                 295                 300                 


Leu Ala Glu Arg Leu Lys Lys Leu Ile Glu Gln Tyr Glu Leu Arg Glu 
305                 310                 315                 320 


Glu His Ile Asp Lys Val Phe Lys His Lys Asp Leu Gln Gln Gln Leu 
                325                 330                 335     


Val Asp Ala Lys Leu Gln Gln Ala Gln Glu Met Leu Lys Glu Ala Glu 
            340                 345                 350         


Glu Arg His Gln Arg Glu Lys Asp Phe Leu Leu Lys Glu Ala Val Glu 
        355                 360                 365             


Ser Gln Arg Met Cys Glu Leu Met Lys Gln Gln Glu Thr His Leu Lys 
    370                 375                 380                 


Gln Gln Leu Ala Leu Tyr Thr Glu Lys Phe Glu Glu Phe Gln Asn Thr 
385                 390                 395                 400 


Leu Ser Lys Ser Ser Glu Val Phe Thr Thr Phe Lys Gln Glu Met Glu 
                405                 410                 415     


Lys Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Thr Met Tyr 
            420                 425                 430         


Arg Ser Arg Trp Glu Ser Ser Asn Lys Ala Leu Leu Glu Met Ala Glu 
        435                 440                 445             


Glu Lys Thr Val Arg Asp Lys Glu Leu Glu Gly Leu Gln Val Lys Ile 
    450                 455                 460                 


Gln Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Asp 
465                 470                 475                 480 


Leu Asn Lys Arg Val Gln Asp Leu Ser Ala Gly Gly Gln Gly Ser Leu 
                485                 490                 495     


Thr Asp Ser Gly Pro Glu Arg Arg Pro Glu Gly Pro Gly Ala Gln Ala 
            500                 505                 510         


Pro Ser Ser Pro Arg Val Thr Glu Ala Pro Cys Tyr Pro Gly Ala Pro 
        515                 520                 525             


Ser Thr Glu Ala Ser Gly Gln Thr Gly Pro Gln Glu Pro Thr Ser Ala 
    530                 535                 540                 


Arg Ala 
545     


<210>  4210
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-14__Homo_sapiens__AAI03824

<400>  4210
augaagaacc aagacaaaaa gaacggggcu gccaaacaau ccaauccaaa aagcagccca       60

ggacaaccgg aagcaggacc cgagggagcc caggagcggc ccagccaggc ggcuccugca      120

guagaagcag aaggucccgg cagcagccag gcuccucgga agccggaggg ggcucaagcc      180

agaacggcuc agucuggggc ccuucgugau gucucugagg agcugagccg ccaacuggaa      240

gacauacuga gcacauacug uguggacaau aaccaggggg gccccggcga ggauggggca      300

cagggugagc cggcugaacc cgaagaugca gagaaguccc ggaccuaugu ggcaaggaau      360

ggggagccug aaccaacucc aguagucaau ggagagaagg aacccuccaa gggggaucca      420

aacacagaag agauccggca gagugacgag gucggagacc gagaccaucg aaggccacag      480

gagaagaaaa aagccaaggg uuuggggaag gagaucacgu ugcugaugca gacauugaau      540

acucugagua ccccagagga gaagcuggcu gcucugugca agaaguaugc ugaacugcug      600

gaggagcacc ggaauucaca gaagcagaug aagcuccuac agaaaaagca gagccagcug      660

gugcaagaga aggaccaccu gcgcggugag cacagcaagg ccguccuggc ccgcagcaag      720

cuugagagcc uaugccguga gcugcagcgg cacaaccgcu cccucaagga agaaggugug      780

cagcgggccc gggaggagga ggagaagcgc aaggagguga ccucgcacuu ccaggugaca      840

cugaaugaca uucagcugca gauggaacag cacaaugagc gcaacuccaa gcugcgccaa      900

gagaacaugg agcuggcuga gaggcucaag aagcugauug agcaguauga gcugcgcgag      960

gagcauaucg acaaagucuu caaacacaag gaccuacaac agcagcuggu ggaugccaag     1020

cuccagcagg cccaggagau gcuaaaggag gcagaagagc ggcaccagcg ggagaaggau     1080

uuucuccuga aagaggcagu agagucccag aggaugugug agcugaugaa gcagcaagag     1140

acccaccuga agcaacagcu ugcccuauac acagagaagu uugaggaguu ccagaacaca     1200

cuuuccaaaa gcagcgaggu auucaccaca uucaagcagg agauggaaaa gaugacuaag     1260

aagaucaaga agcuggagaa agaaaccacc auguaccggu cccgguggga gagcagcaac     1320

aaggcccugc uugagauggc ugaggagaaa acaguccggg auaaagaacu ggagggccug     1380

cagguaaaaa uccaacggcu ggagaagcug ugccgggcac ugcagacaga gcgcaaugac     1440

cugaacaaga ggguacagga ccugagugcu gguggccagg gcucccucac ugacaguggc     1500

ccugagagga ggccagaggg gccuggggcu caagcaccca gcucccccag ggucacagaa     1560

gcgccuugcu acccaggagc accgagcaca gaagcaucag gccagacugg gccucaagag     1620

cccaccuccg ccagggccua g                                               1641


<210>  4211
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-14__Homo_sapiens__AAI03824

<400>  4211
augaagaacc aggacaagaa gaacggcgcc gccaagcaga gcaaccccaa guccagcccg       60

gggcagcccg aggcgggccc cgagggggcc caggagcgcc ccucccaggc cgccccggcc      120

guggaggcgg agggccccgg gagcucccag gcgccccgga agcccgaggg cgcccaggcc      180

cgcaccgccc agagcggcgc ccugcgggac gucuccgagg agcucagccg ccagcuggag      240

gacauccugu ccaccuacug cguggacaac aaccagggcg ggccggggga ggacggcgcc      300

cagggggagc ccgccgagcc cgaggacgcc gagaaguccc ggacguacgu ggcgcgcaac      360

ggcgagcccg agccgacccc cgucgugaac ggcgagaagg agcccagcaa gggggacccc      420

aacaccgagg agauccggca gagcgacgag gugggcgacc gcgaccaccg gcgcccgcag      480

gagaagaaga aggccaaggg gcucggcaag gagaucaccc ugcugaugca gacgcucaac      540

acccugucca cccccgagga gaagcuggcc gcccucugca agaaguacgc cgagcugcug      600

gaggagcacc ggaacagcca gaagcagaug aagcuccugc agaagaagca gucccagcug      660

guccaggaga aggaccaccu ccgcggcgag cacagcaagg cggugcuggc ccgguccaag      720

cuggagagcc ucugccgcga gcugcagcgg cacaaccgcu cccugaagga ggagggggug      780

cagcgggccc gcgaggagga ggagaagcgg aaggagguca ccagccacuu ccaggugacg      840

cucaacgaca uccagcugca gauggagcag cacaacgagc gcaacagcaa gcugcggcag      900

gagaacaugg agcucgccga gcgccugaag aagcugaucg agcaguacga gcuccgcgag      960

gagcacaucg acaagguguu caagcacaag gaccugcagc agcagcuggu cgacgccaag     1020

cuccagcagg cgcaggagau gcugaaggag gccgaggagc ggcaccagcg cgagaaggac     1080

uuccugcuca aggaggccgu ggagucccag cggaugugcg agcugaugaa gcagcaggag     1140

acccaccuga agcagcagcu cgcccuguac accgagaagu ucgaggaguu ccagaacacc     1200

cugagcaagu ccagcgaggu guucacgacc uucaagcagg agauggagaa gaugaccaag     1260

aagaucaaga agcucgagaa ggagaccacg auguaccgcu cccgguggga gagcuccaac     1320

aaggcccugc uggagauggc ggaggagaag accguccgcg acaaggagcu cgagggccuc     1380

caggugaaga uccagcggcu ggagaagcug ugccgcgccc ugcagaccga gcggaacgac     1440

cugaacaagc gcgugcagga ccucagcgcc gggggccagg ggucccugac cgacagcggc     1500

cccgagcggc gccccgaggg cccgggggcc caggcgcccu ccagcccccg ggucacggag     1560

gcccccugcu acccgggcgc ccccuccacc gaggccagcg ggcagaccgg cccccaggag     1620

cccaccuccg cccgcgcgug a                                               1641


<210>  4212
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-14__Homo_sapiens__AAI03824

<400>  4212
augaagaacc aggacaagaa gaacggcgcc gccaagcagu ccaaccccaa guccuccccc       60

ggccagcccg aggccggccc cgagggcgcc caggagcgcc ccucccaggc cgcccccgcc      120

gucgaggccg agggccccgg cuccucccag gccccccgca agcccgaggg cgcccaggcc      180

cgcaccgccc aguccggcgc ccuccgcgac gucuccgagg agcucucccg ccagcucgag      240

gacauccucu ccaccuacug cgucgacaac aaccagggcg gccccggcga ggacggcgcc      300

cagggcgagc ccgccgagcc cgaggacgcc gagaaguccc gcaccuacgu cgcccgcaac      360

ggcgagcccg agcccacccc cgucgucaac ggcgagaagg agcccuccaa gggcgacccc      420

aacaccgagg agauccgcca guccgacgag gucggcgacc gcgaccaccg ccgcccccag      480

gagaagaaga aggccaaggg ccucggcaag gagaucaccc uccucaugca gacccucaac      540

acccucucca cccccgagga gaagcucgcc gcccucugca agaaguacgc cgagcuccuc      600

gaggagcacc gcaacuccca gaagcagaug aagcuccucc agaagaagca gucccagcuc      660

guccaggaga aggaccaccu ccgcggcgag cacuccaagg ccguccucgc ccgcuccaag      720

cucgaguccc ucugccgcga gcuccagcgc cacaaccgcu cccucaagga ggagggcguc      780

cagcgcgccc gcgaggagga ggagaagcgc aaggagguca ccucccacuu ccaggucacc      840

cucaacgaca uccagcucca gauggagcag cacaacgagc gcaacuccaa gcuccgccag      900

gagaacaugg agcucgccga gcgccucaag aagcucaucg agcaguacga gcuccgcgag      960

gagcacaucg acaaggucuu caagcacaag gaccuccagc agcagcucgu cgacgccaag     1020

cuccagcagg cccaggagau gcucaaggag gccgaggagc gccaccagcg cgagaaggac     1080

uuccuccuca aggaggccgu cgagucccag cgcaugugcg agcucaugaa gcagcaggag     1140

acccaccuca agcagcagcu cgcccucuac accgagaagu ucgaggaguu ccagaacacc     1200

cucuccaagu ccuccgaggu cuucaccacc uucaagcagg agauggagaa gaugaccaag     1260

aagaucaaga agcucgagaa ggagaccacc auguaccgcu cccgcuggga guccuccaac     1320

aaggcccucc ucgagauggc cgaggagaag accguccgcg acaaggagcu cgagggccuc     1380

caggucaaga uccagcgccu cgagaagcuc ugccgcgccc uccagaccga gcgcaacgac     1440

cucaacaagc gcguccagga ccucuccgcc ggcggccagg gcucccucac cgacuccggc     1500

cccgagcgcc gccccgaggg ccccggcgcc caggcccccu ccuccccccg cgucaccgag     1560

gcccccugcu accccggcgc ccccuccacc gaggccuccg gccagaccgg cccccaggag     1620

cccaccuccg cccgcgccug a                                               1641


<210>  4213
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-14__Homo_sapiens__AAI03824

<400>  4213
augaagaacc aggacaaaaa gaauggcgcc gcuaaacaaa gcaaccccaa guccucuccu       60

gggcagccag aggcaggacc ggaaggugcc caggagagac ccucacaggc ggcuccugcc      120

guggaagcag agggcccagg gaguagccaa gcccccagga aaccugaagg agcucaggca      180

cggaccgccc aguccggcgc ucugcgcgau gucucugagg agcucucgcg acagcuugaa      240

gacauccugu caacauacug cguugauaau aaccaaggug ggccaggaga ggacggcgcc      300

cagggcgaac ccgcggagcc ugaggaugca gaaaagagcc guacuuaugu ggccagaaau      360

ggggagccag aaccgacgcc cguagugaac ggagagaagg aaccuaguaa aggugaccca      420

aauaccgagg agauuaggca guccgaugaa gucggcgacc gggaucaccg cagaccccag      480

gagaagaaaa aggcuaaagg guugggaaag gaaauaacau uacugaugca aacucuaaac      540

acccucucua caccugagga aaagcuggcc gcacuuugua aaaaguacgc ugagcuguug      600

gaggaacaua ggaauagcca gaaacagaug aagcuccugc agaaaaagca aucccagcug      660

gugcaggaga aagaccaccu ccggggcgaa cauucaaagg ccguuuuagc gcgcaguaag      720

cuggagagcc uuugccgaga auugcaaaga cacaacaggu cucugaaaga ggagggugug      780

cagcgggccc gugaagagga agagaagcgc aaagagguca ccucccauuu ccaggugacu      840

cuaaaugaua uccagcucca aauggaacag cacaacgaga gaaauucaaa gcugaggcag      900

gaaaacaugg agcuugcaga acggcugaaa aaguugauug agcaguauga gcuccgagaa      960

gaacacaucg acaagguauu uaaacauaag gaucugcaac agcaguuagu ugacgcuaaa     1020

cugcagcaag cccaggaaau gcucaaggag gcugaggagc gccaccagag agagaaagac     1080

uuccuucuga aggaagccgu ggagagccaa aggaugugug aauugaugaa gcagcaggag     1140

acacaucuaa aacagcaacu ggcacucuac accgaaaagu uugaggaguu ccagaauacg     1200

cugaguaaau cuuccgaagu cuuuacuacc uucaagcagg agauggagaa aaugacaaag     1260

aagauuaaaa agcuggaaaa agagacuacc auguaucgga gccgcuggga aucgucuaac     1320

aaggcccugu uggagauggc ugaagagaaa acagugagag auaaggaacu cgaggggcuu     1380

caggugaaaa uccaaagguu agagaagcug ugccgugcgc uacagaccga acggaacgac     1440

cucaauaagc gaguccagga ucuguccgca ggaggccagg gcucacuuac ggacaguggg     1500

ccagagagaa ggcccgaagg accgggugcc caagcuccua gcucuccccg cguuacugag     1560

gccccauguu acccuggcgc acccuccaca gaagccagcg ggcagaccgg accacaggag     1620

cccacuucag cucgggccug a                                               1641


<210>  4214
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-14__Homo_sapiens__AAI03824

<400>  4214
augaagaacc aggacaagaa gaacggcgcc gccaagcaga gcaaccccaa gagcagcccc       60

ggccagcccg aggccggccc cgagggcgcc caggagagac ccagccaggc cgcccccgcc      120

guggaggccg agggccccgg cagcagccag gcccccagaa agcccgaggg cgcccaggcc      180

agaaccgccc agagcggcgc ccugagagac gugagcgagg agcugagcag acagcuggag      240

gacauccuga gcaccuacug cguggacaac aaccagggcg gccccggcga ggacggcgcc      300

cagggcgagc ccgccgagcc cgaggacgcc gagaagagca gaaccuacgu ggccagaaac      360

ggcgagcccg agcccacccc cguggugaac ggcgagaagg agcccagcaa gggcgacccc      420

aacaccgagg agaucagaca gagcgacgag gugggcgaca gagaccacag aagaccccag      480

gagaagaaga aggccaaggg ccugggcaag gagaucaccc ugcugaugca gacccugaac      540

acccugagca cccccgagga gaagcuggcc gcccugugca agaaguacgc cgagcugcug      600

gaggagcaca gaaacagcca gaagcagaug aagcugcugc agaagaagca gagccagcug      660

gugcaggaga aggaccaccu gagaggcgag cacagcaagg ccgugcuggc cagaagcaag      720

cuggagagcc ugugcagaga gcugcagaga cacaacagaa gccugaagga ggagggcgug      780

cagagagcca gagaggagga ggagaagaga aaggagguga ccagccacuu ccaggugacc      840

cugaacgaca uccagcugca gauggagcag cacaacgaga gaaacagcaa gcugagacag      900

gagaacaugg agcuggccga gagacugaag aagcugaucg agcaguacga gcugagagag      960

gagcacaucg acaagguguu caagcacaag gaccugcagc agcagcuggu ggacgccaag     1020

cugcagcagg cccaggagau gcugaaggag gccgaggaga gacaccagag agagaaggac     1080

uuccugcuga aggaggccgu ggagagccag agaaugugcg agcugaugaa gcagcaggag     1140

acccaccuga agcagcagcu ggcccuguac accgagaagu ucgaggaguu ccagaacacc     1200

cugagcaaga gcagcgaggu guucaccacc uucaagcagg agauggagaa gaugaccaag     1260

aagaucaaga agcuggagaa ggagaccacc auguacagaa gcagauggga gagcagcaac     1320

aaggcccugc uggagauggc cgaggagaag accgugagag acaaggagcu ggagggccug     1380

caggugaaga uccagagacu ggagaagcug ugcagagccc ugcagaccga gagaaacgac     1440

cugaacaaga gagugcagga ccugagcgcc ggcggccagg gcagccugac cgacagcggc     1500

cccgagagaa gacccgaggg ccccggcgcc caggccccca gcagccccag agugaccgag     1560

gcccccugcu accccggcgc ccccagcacc gaggccagcg gccagaccgg cccccaggag     1620

cccaccagcg ccagagccug a                                               1641


<210>  4215
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-14__Homo_sapiens__AAI03824

<400>  4215
augaagaacc aggacaaaaa gaauggcgcc gcuaaacaaa gcaaccccaa guccucuccu       60

gggcagccgg aggccggacc cgaaggcgcg caggagagac cuagccaggc ugcccccgcc      120

guggaagcug aggggccugg auccucucaa gcuccccgga aaccugaagg cgcccaggcc      180

cgcaccgcgc agagcggggc ccugagagau gucuccgagg agcucucucg gcagcuggaa      240

gacauccuua gcacauacug cguugauaau aaccaaggag gcccgggcga ggacggggcu      300

cagggagaac ccgccgagcc ugaggaugcu gaaaaguccc gcacguaugu ggccagaaau      360

ggcgagcccg aaccuacccc cguggucaac ggggagaagg aaccgagcaa aggagacccu      420

aauacagagg agauucggca gucugaugaa gugggcgacc gcgaucacag acggccccag      480

gagaagaaaa aggcgaaagg gcugggaaag gaaaucaccc uccugaugca aacacuuaac      540

acccugucca caccugagga aaagcucgcc gcucugugua aaaaguacgc cgagcugcuc      600

gaggaacauc gcaauagcca gaaacagaug aagcugcuuc agaaaaagca aucucagcug      660

guucaggaga aagaccaccu cagaggcgaa cauuccaagg cugugcuggc ccggagcaaa      720

cuugagucuc ugugccgcga acuccaaaga cacaaccggu cccugaagga ggagggcguc      780

cagcgcgcca gagaagagga agagaagcgg aaagagguga ccagccauuu ccagguuacg      840

cugaaugaua uucagcucca aauggaacag cacaacgaga gaaauuccaa gcugcgccag      900

gaaaacaugg agcuugcuga acggcugaaa aagcucaucg agcaguauga gcugagagag      960

gaacacauug acaagguguu uaaacauaag gaucuucaac agcagcuggu cgacgcgaaa     1020

cuccagcaag cccaggaaau gcugaaggag gcugaggaac gccaccagcg ggagaaagac     1080

uuccugcuca aggaagccgu ggagucucaa agaaugugug aacugaugaa gcagcaggag     1140

acccaucuua aacagcaacu ggcccucuac acagaaaagu uugaggaguu ccagaauacc     1200

cugagcaaau ccagcgaagu guuuacaacc uucaagcagg agauggagaa aaugacgaag     1260

aagaucaaga aacuugaaaa agagacaacc auguaucgcu cucgguggga auccagcaac     1320

aaggcucugc ucgagauggc cgaagagaaa acagucagag auaaggaacu ggaggggcug     1380

cagguuaaaa uccaacgccu cgagaagcug ugccgggcgc uucagaccga aagaaacgac     1440

cugaauaagc gcgugcagga ucucucugcu ggaggccagg ggagccugac cgacuccgga     1500

cccgagcgga gacccgaagg cccuggggcc caagccccgu cuagcccccg ggugacagag     1560

gcuccuuguu accccggagc cccuuccacg gaagcuagcg gccagaccgg cccccaggag     1620

ccgacaucug cccgcgcgug a                                               1641


<210>  4216
<211>  1641
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-14__Homo_sapiens__AAI03824

<400>  4216
augaaaaacc aagacaaaaa aaauggcgca gcaaagcaaa gcaacccuaa aaguagccca       60

ggccaacccg aagcaggacc ggaaggugca caagaaagac caagccaagc cgcaccagca      120

guagaagccg aaggcccagg aagcucacaa gcaccaagga aacccgaagg agcgcaagca      180

cggacagccc aaaguggugc acuaagagau guuucagaag aacuaucacg acaacuagaa      240

gacaucuuau ccaccuauug cguagauaau aaccaaggag gcccaggaga agauggagcc      300

caaggcgaac cagcagaacc ggaagacgcg gaaaaaucaa gaacuuaugu cgcacgaaau      360

ggagaacccg aacccacgcc aguaguaaac ggcgaaaaag aaccaagcaa aggggacccg      420

aauacagaag aaauaagaca aagcgacgaa guaggagaca gggaucacag aagaccucaa      480

gaaaaaaaaa aagccaaagg acugggaaaa gaaauuacau ugcuaaugca aacacuaaau      540

acguuaagca caccagaaga gaaacucgca gcauugugca aaaaauaugc cgaauuacua      600

gaagaacaca gaaacucaca aaaacaaaug aaauuauuac aaaaaaaaca aagccaauua      660

guccaagaaa aggaccauuu aagaggagaa cacucaaaag caguacuagc acgaaguaaa      720

cucgaaucac uuuguaggga auuacaaagg cacaauagau cacuaaaaga agaaggagua      780

caaagagcac gagaagaaga ggagaaacga aaagaaguaa cgagucauuu ccaaguuaca      840

uuaaaugaua uccaauuaca aauggaacaa cacaacgaaa gaaauucaaa guuacgacaa      900

gaaaauaugg aacuagcaga aagauuaaaa aaauuaauag aacaauauga acuaagagaa      960

gaacauauug auaaaguauu uaaacauaaa gacuuacaac aacaacuagu agacgccaaa     1020

cuacaacaag cacaagaaau guugaaagaa gccgaagaac gacaccaaag agaaaaagau     1080

uucuuauuaa aggaagcagu agaaagucag agaaugugug aauuaaugaa acaacaagaa     1140

acccacuuaa aacaacaacu ugcauuauac acagaaaaau uugaagaauu ccaaaacaca     1200

uuaucaaagu caagugaggu uuuuacaaca uuuaaacaag aaauggaaaa aaugaccaaa     1260

aagauaaaaa aauuagaaaa agaaaccaca auguauagaa gcagauggga aucaucaaau     1320

aaagcacuac uagaaauggc agaagaaaag acaguaagag auaaagaauu agaagguuug     1380

caagugaaaa uacaaagacu agaaaaacua ugcagagcac uacaaacaga aaggaacgau     1440

uuaaauaaaa gaguacaaga cuuaucagca ggaggacaag gaagucuaac agacucagga     1500

ccagaaagac gaccugaagg accuggcgca caagcaccau caagucccag aguaacagag     1560

gcaccaugcu accccggagc acccaguaca gaagcuagcg gacagacggg accacaagaa     1620

ccaacgucag caagagcgua a                                               1641


<210>  4217
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-15__Homo_sapiens__P40933

<400>  4217

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  4218
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-15__Homo_sapiens__AAA21551

<400>  4218
augagaauuu cgaaaccaca uuugagaagu auuuccaucc agugcuacuu guguuuacuu       60

cuaaacaguc auuuucuaac ugaagcuggc auucaugucu ucauuuuggg cuguuucagu      120

gcagggcuuc cuaaaacaga agccaacugg gugaauguaa uaagugauuu gaaaaaaauu      180

gaagaucuua uucaaucuau gcauauugau gcuacuuuau auacggaaag ugauguucac      240

cccaguugca aaguaacagc aaugaagugc uuucucuugg aguuacaagu uauuucacuu      300

gaguccggag augcaaguau ucaugauaca guagaaaauc ugaucauccu agcaaacaac      360

aguuugucuu cuaaugggaa uguaacagaa ucuggaugca aagaauguga ggaacuggag      420

gaaaaaaaua uuaaagaauu uuugcagagu uuuguacaua uuguccaaau guucaucaac      480

acuucuuga                                                              489


<210>  4219
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-15__Homo_sapiens__AAA21551

<400>  4219
augcgcauca gcaagcccca ccuccggucc aucagcaucc agugcuaccu gugccugcug       60

cucaacuccc acuuccugac cgaggccggc auccacgugu ucauccuggg gugcuucagc      120

gccggccucc cgaagaccga ggcgaacugg gucaacguga ucuccgaccu gaagaagauc      180

gaggaccuga uccagagcau gcacaucgac gccacgcucu acaccgaguc cgacgugcac      240

cccagcugca aggucaccgc caugaagugc uuccugcugg agcuccaggu gaucucccug      300

gagagcgggg acgccuccau ccacgacacc guggagaacc ugaucauccu cgccaacaac      360

agccugucca gcaacggcaa cgucacggag uccgggugca aggagugcga ggagcuggag      420

gagaagaaca ucaaggaguu ccuccagagc uucgugcaca ucgugcagau guucaucaac      480

accuccuga                                                              489


<210>  4220
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-15__Homo_sapiens__AAA21551

<400>  4220
augcgcaucu ccaagcccca ccuccgcucc aucuccaucc agugcuaccu cugccuccuc       60

cucaacuccc acuuccucac cgaggccggc auccacgucu ucauccucgg cugcuucucc      120

gccggccucc ccaagaccga ggccaacugg gucaacguca ucuccgaccu caagaagauc      180

gaggaccuca uccaguccau gcacaucgac gccacccucu acaccgaguc cgacguccac      240

cccuccugca aggucaccgc caugaagugc uuccuccucg agcuccaggu caucucccuc      300

gaguccggcg acgccuccau ccacgacacc gucgagaacc ucaucauccu cgccaacaac      360

ucccucuccu ccaacggcaa cgucaccgag uccggcugca aggagugcga ggagcucgag      420

gagaagaaca ucaaggaguu ccuccagucc uucguccaca ucguccagau guucaucaac      480

accuccuga                                                              489


<210>  4221
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-15__Homo_sapiens__AAA21551

<400>  4221
augagaauca gcaagcccca ccugaggucc auuucuauac agugcuaccu cugucuucug       60

uugaacucac auuucuuaac cgaagccggc auccacgugu uuauucuggg gugcuucagu      120

gcuggacuac cuaaaacaga agcaaauugg gucaacguua ucagcgaccu caagaaaauu      180

gaggaucuga uccaauccau gcauauagac gccacucuuu auacggaauc ugaugugcac      240

ccaucgugua agguaaccgc gaugaaaugc uuucuguugg agcuccaggu gaucucacug      300

gaaagcggug acgcuaguau ucaugauaca gucgagaauc ugaucauucu cgccaacaau      360

uccuuaucua gcaacggcaa ugugacugag uccgggugua aggaaugcga ggaacuggag      420

gagaagaaca ucaaagaguu ccuucaguca uuuguucaca uagugcagau guucauuaau      480

accaguuga                                                              489


<210>  4222
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-15__Homo_sapiens__AAA21551

<400>  4222
augagaauca gcaagcccca ccugagaagc aucagcaucc agugcuaccu gugccugcug       60

cugaacagcc acuuccugac cgaggccggc auccacgugu ucauccuggg cugcuucagc      120

gccggccugc ccaagaccga ggccaacugg gugaacguga ucagcgaccu gaagaagauc      180

gaggaccuga uccagagcau gcacaucgac gccacccugu acaccgagag cgacgugcac      240

cccagcugca aggugaccgc caugaagugc uuccugcugg agcugcaggu gaucagccug      300

gagagcggcg acgccagcau ccacgacacc guggagaacc ugaucauccu ggccaacaac      360

agccugagca gcaacggcaa cgugaccgag agcggcugca aggagugcga ggagcuggag      420

gagaagaaca ucaaggaguu ccugcagagc uucgugcaca ucgugcagau guucaucaac      480

accagcuga                                                              489


<210>  4223
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-15__Homo_sapiens__AAA21551

<400>  4223
augagaauca gcaagcccca ucugcggucc auuucuaucc agugcuaccu cugucugcuu       60

cugaacagcc acuuccucac cgaagccggc auucacgugu uuauccuggg gugcuucucc      120

gcuggacuuc cuaaaacaga agccaauugg gucaacguua uuucugaccu gaagaaaauc      180

gaggaucuca uccaaagcau gcauauugac gcgacgcugu auaccgaauc cgaugugcac      240

ccgucuugua aggugacagc uaugaaaugc uuucugcucg agcugcaggu caucagccuu      300

gaauccggcg acgccagcau ucaugauacc guggagaauc ugaucauucu cgccaacaau      360

ucucugucca gcaacgggaa uguuacagag ucuggaugua aggaaugcga ggaacuugag      420

gagaagaaca ucaaagaguu ccugcagucc uuugugcaca uuguccagau guucaucaau      480

accagcuga                                                              489


<210>  4224
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-15__Homo_sapiens__AAA21551

<400>  4224
augagaauau caaaaccaca ccucagauca auaucaauac aaugcuacuu augccuacua       60

cuaaacucac acuuccuaac agaagcagga auacacguau ucauacucgg augcuucagc      120

gcaggacuac caaaaacaga agcaaacugg guaaacguaa uaucagaccu aaaaaaaaua      180

gaagaccuaa uacaaucaau gcacauagac gccacacuau acacagaauc agacguacac      240

ccaucaugca aaguaacagc aaugaaaugc uuccuacuag aacuacaagu aauaucacuc      300

gaaucaggag acgcaucaau acacgacaca guagaaaacc uaauaauacu agcaaacaac      360

ucacuaucau caaacggaaa cguaacagaa ucaggaugca aagaaugcga agaauuagaa      420

gaaaaaaaca uaaaagaauu ccuacaauca uucguacaca uaguacaaau guucauaaac      480

acaucauaa                                                              489


<210>  4225
<211>  1332
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-16__Homo_sapiens__Q14005

<400>  4225

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu Pro Ser Ser 
        995                 1000                1005            


Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly Ala Ser Pro 
    1010                1015                1020                


Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser Ala Glu Thr 
1025                1030                1035                1040


Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu Leu Arg Glu 
                1045                1050                1055    


Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp Gly Asp His 
            1060                1065                1070        


Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu Ser Ser Glu 
        1075                1080                1085            


Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp Glu Ala Thr 
    1090                1095                1100                


Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His Lys Glu Glu 
1105                1110                1115                1120


Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp Leu Glu Asn 
                1125                1130                1135    


Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu Ala Ser Gln 
            1140                1145                1150        


Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile Asn Gly Lys 
        1155                1160                1165            


Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile Leu Arg Gln 
    1170                1175                1180                


Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys Leu Thr Pro 
1185                1190                1195                1200


Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala Ala Ser Ala 
                1205                1210                1215    


Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu Ala Thr Val 
            1220                1225                1230        


Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly Phe Ser Leu 
        1235                1240                1245            


Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu Thr Ile Asn 
    1250                1255                1260                


Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr Val Gln Pro 
1265                1270                1275                1280


Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln Gly Leu Thr 
                1285                1290                1295    


Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp Gly Pro Val 
            1300                1305                1310        


Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu Thr Thr Ala 
        1315                1320                1325            


Ala Gly Asp Ser 
    1330        


<210>  4226
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-16__Homo_sapiens__CCDS42069.1

<400>  4226
auggagucgc acagccgcgc uggaaagagc agaaaaucug caaaauuucg guccaucucc       60

aggucccuga ugcucuguaa ugcuaagacc agugaugaug gcucuagccc ugaugagaaa      120

uauccugauc ccuuugagau uuccuuggcc cagggcaagg agggaauuuu ccacucaucu      180

gugcagcugg cagacacauc ggaggcuggg cccagcagug uuccugaucu agcacuggcc      240

ucggaggcug cucaacucca agcagcuggg aaugaucgag gcaagaccug uaggaggaua      300

uucuucauga aggaaucuuc cacagcuucc ucucgagaaa agccuggaaa acuagaagca      360

caaaguagua acuuccuguu uccuaaagcc ugccaccaaa gggcacgcag caacucaacc      420

aguguuaauc ccuauugcac aagagaaauu gauuuuccaa ugaccaagaa aucugcagcg      480

cccacggaca ggcagccuua cucucucugc aguaacagga agucccucuc ucaacaauug      540

gacuguccag caggaaaggc ugcgggaacu ucgagaccaa cacggucccu gagcacagcu      600

cagcucgugc agccaucugg gggccuccag gcuucaguca ucuccaacau cgugcugaug      660

aagggccagg cuaagggucu gggcuucagc aucguugggg gaaaagacag cauuuauggc      720

cccauuggga uuuacgucaa aaccauuuuu gcagggggag cagcagcagc cgauggaagg      780

cuacaggaag gugaugaaau ucuggagcuc aauggugaau caauggcugg acuaacacau      840

caggaugcuu ugcagaaguu caagcaagcc aaaaaggggc uccucacccu caccgugaga      900

acccgccuga cggcgccucc uucccugugc agccaccugu cucccccacu gugccgcucc      960

cugagcucca gcacuuguau caccaaggac agcagcuccu ucgccuugga aagccccucg     1020

gcucccauca gcaccgccaa gcccaauuac agaaucaugg uggagguuuc ucugcagaaa     1080

gaggccggcg ugggccuggg caucggccug ugcagcguuc ccuacuucca augcaucucu     1140

ggcauuuucg uccacacgcu gucaccagga uccguggcgc accuggacgg acgucuccgg     1200

uguggggacg agauugugga aaucagugau uccccugugc acugccugac gcucaaugaa     1260

gucuacacga uccugaguca cugugauccc gguccagucc ccaucauugu uagccgacau     1320

ccagacccac aggucucuga acagcaacuc aaagaagcug uggcccaggc uguggaaaac     1380

accaaguuug gaaaggagag gcaucagugg agucuggaag gugucaaaag gcuggaaagc     1440

aguuggcacg ggcggcccac cuuggagaag gaacgagaga agaacucagc acccccgcau     1500

cgcagggcuc agaaggucau gauccgcucc agcagugaca gcagcuacau gucugggucc     1560

ccagggggaa guccugggag uggcagugcu gagaagccgu ccucugacgu ggacaucagc     1620

acacacagcc ccagcuugcc ucuggcacgg gagccagugg ugcuuucuau agcauccucc     1680

aggcugcccc aggagagccc accccuccca gagagccggg acagccaccc gccgcugaga     1740

cugaagaaau ccuuugagau uuuggugaga aagccuaugu ccuccaagcc caagccucca     1800

cccagaaaau acuuuaaaag ugacagugac ccucagaaga gucuggaaga gagagagaac     1860

uccucaugcu cuucugggca caccccaccc accuguggcc aggaagcgag agagcugcug     1920

ccacugcugc uaccacagga agacacagca gggagaagcc cuagugccuc ugccggcugc     1980

ccaggaccug guaucggccc acagaccaag uccuccacag agggcgagcc aggguggaga     2040

agagccagcc cagugaccca aacauccccg auaaaacacc cacugcuuaa gaggcaggcu     2100

cggauggacu auagcuuuga uaccacagcc gaagacccuu ggguuaggau uucugacugc     2160

aucaaaaacu uauuuagccc caucaugagu gagaaccaug gccacaugcc ucuacagccc     2220

aaugccagcc ugaaugaaga agaagggaca cagggccacc cagaugggac cccaccaaag     2280

cuggacaccg ccaauggcac ucccaaaguu uacaagucag cagacagcag cacugugaag     2340

aaagguccuc cuguggcucc caagccagcc ugguuucgcc aaagcuugaa agguuugagg     2400

aaucgugcuu cagacccaag agggcucccu gauccugccu uguccaccca gccagcaccu     2460

gcuuccaggg agcaccuagg aucacacauc cgggccuccu ccuccuccuc cuccaucagg     2520

cagagaauca gcuccuuuga aaccuuuggc uccucucaac ugccugacaa aggagcccag     2580

agacugagcc uccagcccuc cucuggggag gcagcaaaac cucuugggaa gcaugaggaa     2640

ggacgguuuu cuggacucuu ggggcgaggg gcugcaccca cucuugugcc ccagcagccu     2700

gagcaaguac uguccucggg guccccugca gccuccgagg ccagagaccc aggugugucu     2760

gaguccccuc ccccagggcg gcagcccaau cagaaaacuc uccccccugg cccggacccg     2820

cuccuaaggc ugcugucaac acaggcugag gaaucucaag gcccagugcu caagaugccu     2880

agccagcgag cacggagcuu cccccugacc aggucccagu ccugugagac gaagcuacuu     2940

gacgaaaaga ccagcaaacu cuauucuauc agcagccaag ugucaucggc ugucaugaaa     3000

uccuugcugu gccuuccauc uucuaucucc ugugcccaga cucccugcau ccccaaggaa     3060

ggggcaucuc caacaucauc auccaacgaa gacucagcug caaaugguuc ugcugaaaca     3120

ucugccuugg acacaggguu cucgcucaac cuuucagagc ugagagaaua uacagagggu     3180

cucacggaag ccaaggaaga cgaugauggg gaccacaguu cccuucaguc uggucagucc     3240

guuaucuccc ugcugagcuc agaagaauua aaaaaacuca ucgaggaggu gaagguucug     3300

gaugaagcaa cauuaaagca auuagacggc auccauguca ccaucuuaca caaggaggaa     3360

ggugcugguc uuggguucag cuuggcagga ggagcagauc uagaaaacaa ggugauuacg     3420

guucacagag uguuuccaaa ugggcuggcc ucccaggaag ggacuauuca gaagggcaau     3480

gagguucuuu ccaucaacgg caagucucuc aaggggacca cgcaccauga ugccuuggcc     3540

auccuccgcc aagcucgaga gcccaggcaa gcugugauug ucacaaggaa gcugacucca     3600

gaggccaugc ccgaccucaa cuccuccacu gacucugcag ccucagccuc ugcagccagu     3660

gauguuucug uagaaucuac agcagaggcc acagucugca cggugacacu ggagaagaug     3720

ucggcagggc ugggcuucag ccuggaagga gggaagggcu cccuacacgg agacaagccu     3780

cucaccauua acaggauuuu caaaggagca gccucagaac aaagugagac aguccagccu     3840

ggagaugaaa ucuuacagcu ggguggcacu gccaugcagg gccucacacg guuugaagcc     3900

uggaacauca ucaaggcacu gccugaugga ccugucacga uugucaucag gagaaaaagc     3960

cuccagucca aggaaaccac agcugcugga gacuccuag                            3999


<210>  4227
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4227
auggagagcc acucccgcgc cggcaagagc cggaaguccg ccaaguuccg cagcaucucc       60

cggagccuga ugcucugcaa cgcgaagacc uccgacgacg ggagcucccc cgacgagaag      120

uacccggacc ccuucgagau cagccuggcc cagggcaagg aggggaucuu ccacuccagc      180

gugcagcugg ccgacaccuc cgaggccggc cccagcuccg uccccgaccu cgcccuggcg      240

agcgaggccg cccagcugca ggccgcgggg aacgaccgcg gcaagacgug ccggcgcauc      300

uucuucauga aggaguccag caccgccucc agccgggaga agccgggcaa gcucgaggcc      360

cagagcucca acuuccuguu ccccaaggcc ugccaccagc gcgcccggag caacuccacc      420

agcgugaacc ccuacugcac ccgcgagauc gacuucccca ugacgaagaa guccgcggcc      480

ccgaccgacc ggcagcccua cagccugugc uccaaccgca agagccucuc ccagcagcug      540

gacugccccg ccgggaaggc cgccggcacc agccggccca cccgcucccu gagcacggcg      600

cagcucgugc agccguccgg gggccugcag gccagcguca ucuccaacau cgugcugaug      660

aaggggcagg ccaagggccu cggcuucagc aucguggggg gcaaggacuc caucuacggg      720

cccaucggca ucuacgucaa gaccaucuuc gccggcgggg ccgcggccgc cgacggccgg      780

cugcaggagg gggacgagau ccuggagcuc aacggcgaga gcauggccgg gcugacccac      840

caggacgccc ugcagaaguu caagcaggcg aagaagggcc uccugacccu gacggugcgc      900

acccggcuca ccgccccccc cucccugugc agccaccuga gcccgccccu cugccgcucc      960

cugagcucca gcaccugcau cacgaaggac uccagcuccu ucgcccugga gagccccucc     1020

gcccccauca gcaccgcgaa gccgaacuac cggaucaugg uggaggucuc ccuccagaag     1080

gaggccggcg uggggcuggg caucgggcug ugcagcgugc ccuacuucca gugcaucucc     1140

ggcaucuucg uccacacccu cagccccggg uccguggccc accuggacgg ccgccugcgg     1200

ugcggcgacg agaucgugga gaucagcgac ucccccgucc acugccucac ccugaacgag     1260

guguacacga uccugagcca cugcgacccg gggcccgugc ccaucaucgu cagccgccac     1320

cccgacccgc agguguccga gcagcagcuc aaggaggccg uggcccaggc ggucgagaac     1380

accaaguucg gcaaggagcg ccaccagugg agccuggagg gggugaagcg gcuggagucc     1440

agcuggcacg gccgccccac ccucgagaag gagcgggaga agaacuccgc ccccccgcac     1500

cgccgggccc agaaggugau gauccgcagc uccagcgacu ccagcuacau guccgggagc     1560

cccggcggcu cccccgggag cggcuccgcc gagaagccca gcuccgacgu cgacaucagc     1620

acccacuccc cgagccugcc ccuggcccgg gagcccgugg uccucagcau cgcguccagc     1680

cgccugcccc aggagucccc gccccugccc gagagccggg acucccaccc cccgcuccgc     1740

cugaagaaga gcuucgagau ccuggugcgg aagcccaugu ccagcaagcc caagcccccg     1800

ccccgcaagu acuucaaguc cgacagcgac ccccagaagu cccuggagga gcgggagaac     1860

agcuccugca gcuccgggca cacgcccccg accugcggcc aggaggcccg cgagcuccug     1920

ccccugcucc ugccccagga ggacaccgcc ggccggagcc ccuccgccag cgccgggugc     1980

ccgggccccg ggaucggccc ccagaccaag uccagcacgg agggggagcc gggcuggcgc     2040

cgggcgagcc ccgugaccca gaccuccccc aucaagcacc cccugcucaa gcgccaggcc     2100

cggauggacu acagcuucga caccacggcc gaggacccgu ggguccgcau cuccgacugc     2160

aucaagaacc uguucagccc caucaugucc gagaaccacg gccacaugcc ccugcagccc     2220

aacgccagcc ucaacgagga ggaggggacc cagggccacc cggacgggac cccccccaag     2280

cuggacaccg cgaacggcac gcccaaggug uacaaguccg ccgacagcuc caccgugaag     2340

aaggggccgc ccgucgcccc caagcccgcc ugguuccgcc agagccugaa gggccuccgg     2400

aaccgcgccu ccgacccgcg gggccugccc gaccccgcgc ugagcaccca gcccgccccg     2460

gccucccgcg agcaccucgg gagccacauc cgggccucca gcuccagcuc cagcauccgc     2520

cagcggauca gcuccuucga gaccuucggc agcucccagc ugcccgacaa gggggcccag     2580

cgccugagcc uccagcccuc cagcggcgag gcggccaagc cccuggggaa gcacgaggag     2640

ggccgguucu ccggccugcu cgggcgcggc gccgccccga cccuggugcc ccagcagccc     2700

gagcaggugc ugagcuccgg gagccccgcc gcguccgagg cccgggaccc gggcgucagc     2760

gagucccccc ccccggggcg ccagcccaac cagaagacgc ucccccccgg cccggacccc     2820

cugcugcggc uccugagcac ccaggccgag gagucccagg gccccgugcu gaagaugccc     2880

agccagcgcg cccgguccuu cccgcucacc cgcagccagu ccugcgagac caagcugcug     2940

gacgagaaga cgagcaagcu cuacagcauc uccagccagg uguccagcgc ggucaugaag     3000

ucccugcugu gccuccccag cuccaucagc ugcgcccaga cccccugcau ccccaaggag     3060

ggggccuccc cgaccagcuc cagcaacgag gacuccgccg ccaacggcag cgcggagacc     3120

uccgcccugg acacgggguu cagccugaac cucuccgagc ugcgggagua caccgagggc     3180

cugaccgagg ccaaggagga cgacgacggc gaccacagcu cccuccagag cgggcagagc     3240

gugaucuccc ugcugagcuc cgaggagcuc aagaagcuga ucgaggaggu gaagguccug     3300

gacgaggcca cccucaagca gcuggacggc auccacguga cgauccugca caaggaggag     3360

ggggccggcc ucggguucag ccuggcgggc ggcgccgacc uggagaacaa ggugaucacc     3420

guccaccgcg uguuccccaa cgggcucgcc ucccaggagg gcaccaucca gaaggggaac     3480

gaggugcuga gcaucaacgg caagucccug aaggggacca cgcaccacga cgcccucgcc     3540

auccugcggc aggcgcgcga gccccggcag gccgucaucg ugacccgcaa gcugaccccc     3600

gaggccaugc cggaccucaa cagcuccacc gacagcgccg ccuccgcgag cgccgccucc     3660

gacgugagcg ucgaguccac ggccgaggcg accgugugca ccgugacccu ggagaagaug     3720

agcgccggcc ugggcuucuc ccucgagggg ggcaagggga gccugcacgg cgacaagccc     3780

cugacgauca accgcaucuu caagggggcc gccagcgagc aguccgagac cguccagccc     3840

ggcgacgaga uccuccagcu gggcgggacc gccaugcagg gccugacccg guucgaggcg     3900

uggaacauca ucaaggcccu ccccgacggg ccggugacga ucgugauccg ccggaagagc     3960

cugcagucca aggagaccac cgccgccggc gacagcuga                            3999


<210>  4228
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4228
auggaguccc acucccgcgc cggcaagucc cgcaaguccg ccaaguuccg cuccaucucc       60

cgcucccuca ugcucugcaa cgccaagacc uccgacgacg gcuccucccc cgacgagaag      120

uaccccgacc ccuucgagau cucccucgcc cagggcaagg agggcaucuu ccacuccucc      180

guccagcucg ccgacaccuc cgaggccggc cccuccuccg uccccgaccu cgcccucgcc      240

uccgaggccg cccagcucca ggccgccggc aacgaccgcg gcaagaccug ccgccgcauc      300

uucuucauga aggaguccuc caccgccucc ucccgcgaga agcccggcaa gcucgaggcc      360

caguccucca acuuccucuu ccccaaggcc ugccaccagc gcgcccgcuc caacuccacc      420

uccgucaacc ccuacugcac ccgcgagauc gacuucccca ugaccaagaa guccgccgcc      480

cccaccgacc gccagcccua cucccucugc uccaaccgca agucccucuc ccagcagcuc      540

gacugccccg ccggcaaggc cgccggcacc ucccgcccca cccgcucccu cuccaccgcc      600

cagcucgucc agcccuccgg cggccuccag gccuccguca ucuccaacau cguccucaug      660

aagggccagg ccaagggccu cggcuucucc aucgucggcg gcaaggacuc caucuacggc      720

cccaucggca ucuacgucaa gaccaucuuc gccggcggcg ccgccgccgc cgacggccgc      780

cuccaggagg gcgacgagau ccucgagcuc aacggcgagu ccauggccgg ccucacccac      840

caggacgccc uccagaaguu caagcaggcc aagaagggcc uccucacccu caccguccgc      900

acccgccuca ccgccccccc cucccucugc ucccaccucu cccccccccu cugccgcucc      960

cucuccuccu ccaccugcau caccaaggac uccuccuccu ucgcccucga gucccccucc     1020

gcccccaucu ccaccgccaa gcccaacuac cgcaucaugg ucgaggucuc ccuccagaag     1080

gaggccggcg ucggccucgg caucggccuc ugcuccgucc ccuacuucca gugcaucucc     1140

ggcaucuucg uccacacccu cucccccggc uccgucgccc accucgacgg ccgccuccgc     1200

ugcggcgacg agaucgucga gaucuccgac ucccccgucc acugccucac ccucaacgag     1260

gucuacacca uccucuccca cugcgacccc ggccccgucc ccaucaucgu cucccgccac     1320

cccgaccccc aggucuccga gcagcagcuc aaggaggccg ucgcccaggc cgucgagaac     1380

accaaguucg gcaaggagcg ccaccagugg ucccucgagg gcgucaagcg ccucgagucc     1440

uccuggcacg gccgccccac ccucgagaag gagcgcgaga agaacuccgc ccccccccac     1500

cgccgcgccc agaaggucau gauccgcucc uccuccgacu ccuccuacau guccggcucc     1560

cccggcggcu cccccggcuc cggcuccgcc gagaagcccu ccuccgacgu cgacaucucc     1620

acccacuccc ccucccuccc ccucgcccgc gagcccgucg uccucuccau cgccuccucc     1680

cgccuccccc aggagucccc cccccucccc gagucccgcg acucccaccc cccccuccgc     1740

cucaagaagu ccuucgagau ccucguccgc aagcccaugu ccuccaagcc caagcccccc     1800

ccccgcaagu acuucaaguc cgacuccgac ccccagaagu cccucgagga gcgcgagaac     1860

uccuccugcu ccuccggcca cacccccccc accugcggcc aggaggcccg cgagcuccuc     1920

ccccuccucc ucccccagga ggacaccgcc ggccgcuccc ccuccgccuc cgccggcugc     1980

cccggccccg gcaucggccc ccagaccaag uccuccaccg agggcgagcc cggcuggcgc     2040

cgcgccuccc ccgucaccca gaccuccccc aucaagcacc cccuccucaa gcgccaggcc     2100

cgcauggacu acuccuucga caccaccgcc gaggaccccu ggguccgcau cuccgacugc     2160

aucaagaacc ucuucucccc caucaugucc gagaaccacg gccacaugcc ccuccagccc     2220

aacgccuccc ucaacgagga ggagggcacc cagggccacc ccgacggcac cccccccaag     2280

cucgacaccg ccaacggcac ccccaagguc uacaaguccg ccgacuccuc caccgucaag     2340

aagggccccc ccgucgcccc caagcccgcc ugguuccgcc agucccucaa gggccuccgc     2400

aaccgcgccu ccgacccccg cggccucccc gaccccgccc ucuccaccca gcccgccccc     2460

gccucccgcg agcaccucgg cucccacauc cgcgccuccu ccuccuccuc cuccauccgc     2520

cagcgcaucu ccuccuucga gaccuucggc uccucccagc uccccgacaa gggcgcccag     2580

cgccucuccc uccagcccuc cuccggcgag gccgccaagc cccucggcaa gcacgaggag     2640

ggccgcuucu ccggccuccu cggccgcggc gccgccccca cccucguccc ccagcagccc     2700

gagcaggucc ucuccuccgg cucccccgcc gccuccgagg cccgcgaccc cggcgucucc     2760

gagucccccc cccccggccg ccagcccaac cagaagaccc ucccccccgg ccccgacccc     2820

cuccuccgcc uccucuccac ccaggccgag gagucccagg gccccguccu caagaugccc     2880

ucccagcgcg cccgcuccuu cccccucacc cgcucccagu ccugcgagac caagcuccuc     2940

gacgagaaga ccuccaagcu cuacuccauc uccucccagg ucuccuccgc cgucaugaag     3000

ucccuccucu gccuccccuc cuccaucucc ugcgcccaga cccccugcau ccccaaggag     3060

ggcgccuccc ccaccuccuc cuccaacgag gacuccgccg ccaacggcuc cgccgagacc     3120

uccgcccucg acaccggcuu cucccucaac cucuccgagc uccgcgagua caccgagggc     3180

cucaccgagg ccaaggagga cgacgacggc gaccacuccu cccuccaguc cggccagucc     3240

gucaucuccc uccucuccuc cgaggagcuc aagaagcuca ucgaggaggu caagguccuc     3300

gacgaggcca cccucaagca gcucgacggc auccacguca ccauccucca caaggaggag     3360

ggcgccggcc ucggcuucuc ccucgccggc ggcgccgacc ucgagaacaa ggucaucacc     3420

guccaccgcg ucuuccccaa cggccucgcc ucccaggagg gcaccaucca gaagggcaac     3480

gagguccucu ccaucaacgg caagucccuc aagggcacca cccaccacga cgcccucgcc     3540

auccuccgcc aggcccgcga gccccgccag gccgucaucg ucacccgcaa gcucaccccc     3600

gaggccaugc ccgaccucaa cuccuccacc gacuccgccg ccuccgccuc cgccgccucc     3660

gacgucuccg ucgaguccac cgccgaggcc accgucugca ccgucacccu cgagaagaug     3720

uccgccggcc ucggcuucuc ccucgagggc ggcaagggcu cccuccacgg cgacaagccc     3780

cucaccauca accgcaucuu caagggcgcc gccuccgagc aguccgagac cguccagccc     3840

ggcgacgaga uccuccagcu cggcggcacc gccaugcagg gccucacccg cuucgaggcc     3900

uggaacauca ucaaggcccu ccccgacggc cccgucacca ucgucauccg ccgcaagucc     3960

cuccagucca aggagaccac cgccgccggc gacuccuga                            3999


<210>  4229
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4229
auggagagcc acuccagagc cggcaagucu aggaaaucag cuaaguuccg gaguaucagc       60

cgcucccuga ugcucugcaa cgcaaaaacc ucugacgaug ggucgucacc cgacgaaaag      120

uacccugauc cauuugagau uagccuugcc cagggaaaag aagguauauu ccauaguucc      180

gugcaacugg cggacacauc ugaggcuggc ccgagcuccg uccccgauuu ggccuuagca      240

ucagaagccg cucagcugca ggcagccggg aaugaccgag gaaagacuug ucguagaauc      300

uuuuucauga aggagaguag cacggcuucu uccagggaga aaccuggcaa gcuagaagcc      360

cagucaagca acuuucucuu cccaaaagcg ugccaccaac gggcacgcag uaauucuacc      420

uccguuaacc ccuauuguac aagagagauu gauuuuccua ugacuaagaa aagcgccgcu      480

ccaaccgaca ggcagcccua cucgcugugc ucuaaucgga agucccuuuc acagcagcug      540

gauuguccug ccgguaaggc agcugggaca agucgcccaa cccgaagccu uuccacugcc      600

caacucgugc agccgucugg aggccugcag gcgagcguaa ucucaaacau ugugcugaug      660

aaaggccagg ccaaggggcu cggauucagu aucgucggug gcaaagacuc cauauauggg      720

cccaucggaa uuuacgugaa gacaaucuuu gcaggcggug cugccgcugc cgaugggaga      780

uuacaagaag gagacgagau ucuggagcuu aauggcgaaa gcauggcagg cuugacccau      840

caggaugccc ugcagaaauu caagcaagcu aaaaaggggc uacucacgcu gacuguuagg      900

acccggcuua cagcgccucc aucucugugc ucacacuuga gucccccucu cugucguagc      960

cuguccucuu cgacuugcau caccaaggac agcuccucau uugcauuaga gaguccaucu     1020

gcccccauaa gcacagcuaa accgaacuau cgcauuaugg uggaagucuc ccugcagaag     1080

gaggccggag ugggucucgg caucgggcuu uguucaguac cuuacuucca gugcauuagc     1140

ggaaucuuug uucauacccu gucucccggc uccguggcac acuuggacgg uagacuaagg     1200

uguggggaug aaaucgucga gauuagugac agcccagugc acugccugac gcucaaugag     1260

guguauacua uacugucuca uugcgauccu ggccccgucc caaucauugu uucccggcac     1320

cccgacccuc aggugucaga acaacagcuu aaagaggccg uagcucaggc cguggaaaac     1380

acaaaguucg gaaaagagcg acaucagugg agucuggaag gcgucaagcg cuuggagagc     1440

ucguggcacg ggagaccaac ccucgagaag gaaagggaga aaaauuccgc accgccccac     1500

cggcgcgcgc aaaaggugau gaucagaucu agcucagaua guuccuacau gucuggaagc     1560

ccugguggcu ccccaggguc aggaagcgcu gaaaaaccca guucugacgu ugauauaucc     1620

acucauagcc cuucgcugcc auuagccagg gagcccgugg uccugucaau ugcaucuagu     1680

cgucuaccgc aggaaucccc uccacucccc gagagccggg acucucaccc uccccugcga     1740

cuuaagaaau ccuucgagau cuuggugaga aagccaauga gcucaaagcc uaaaccccca     1800

ccgaggaagu acuuuaaaag ugauagcgac ccucagaagu cucuggagga gcgcgaaaac     1860

uccucaugua guagcggcca uacaccccca accugcgguc aggaggcccg ggagcuccug     1920

ccccuucugu ugccucaaga agauacggcu gggagauccc caucugccuc ggcaggcugu     1980

cccggaccug gcaucgggcc gcagaccaaa agcucaacag agggagaacc agguuggagg     2040

cgcgcuuccc ccguaacuca gaccaguccu auuaagcacc cacuccugaa gcgacaggcc     2100

cggauggacu auucuuucga cacaacugcg gaggaucccu ggguucguau cagcgacugc     2160

auuaaaaauu uauuuucccc uauaauguca gaaaaccaug gccacaugcc gcugcaaccc     2220

aaugccucuc uaaacgagga ggaagggacc cagggacacc cagauggcac accucccaag     2280

cucgacaccg cuaacgguac uccaaaagug uacaagagcg cagauaguuc cacggucaaa     2340

aaggggccuc ccguggcccc aaaaccggcu ugguucagac agagccugaa gggccuuagg     2400

aaucgcgccu cugacccucg gggauugccc gauccagcac ugucaacaca acccgcgccu     2460

gccuccagag agcaucucgg cagucacauc agggcuagcu cgucuuccag cucaauucga     2520

cagcgcauca guucuuuuga aaccuucggg uccagccagc ugccagacaa gggagcccag     2580

cgguuaucac ugcaacccag uagcggcgag gcagcuaaac cucuugguaa gcaugaagag     2640

gggagauuuu ccggauugcu cggcaggggu gccgcaccga cucugguccc acagcagccc     2700

gaacaggugc uaucuagcgg cuccccugcc gcuucagaag cgcgugaucc cgggguuucu     2760

gagaguccac cucccggacg ccaaccaaac cagaaaaccc ugccuccggg ccccgaccca     2820

cuccugcggc uuuugucgac acaggccgaa gagagccagg ggccugugcu gaagaugccc     2880

ucccaaagag caaggucuuu cccauuaacc cgaucacaga gcugugaaac uaaacuccug     2940

gaugagaaga cauccaaguu guauaguauc ucuagccagg uaucauccgc ugucaugaaa     3000

agucuguugu gccucccuag cucuauuucc ugugcccaaa cgcccugcau accgaaggag     3060

ggagccucac caaccagcuc gucuaaugaa gacagugcug caaacggcuc cgccgagacu     3120

agcgcgcugg auacagguuu uucacuaaau cuguccgaac uccgggagua caccgagggg     3180

cugacagaag cuaaagagga cgacgaugga gaccacucua gccuucagag uggccagucc     3240

gugaucagcu ugcugucuuc agaagaguua aagaaacuca uugaagaggu uaaggugcug     3300

gaugaggcca cucuuaagca gcuggacggu auccacguca ccauucuaca uaaagaagag     3360

ggcgcagggc ucggauucag ucuggccggc ggggcugauu uggaaaacaa ggugaucacg     3420

guacaccgcg uguuuccuaa uggacuggca ucccaagagg gcaccauaca gaaagguaac     3480

gaaguuuuaa gcaucaaugg gaagucucuc aaaggaacaa cucaucacga cgcccuggcg     3540

auucuuagac aggcuaggga gccccggcag gccgucaucg ugacccgaaa gcugacacca     3600

gaggcaaugc ccgauuugaa cucgucaacu gacagcgccg cuuccgccag ugcagcuucu     3660

gaugugagcg ucgaauccac cgccgaggcg acgguuugua cagugacccu cgaaaagaug     3720

ucagccggcc uggguuucag ucuagagggc gggaaaggau cucugcaugg cgacaagccu     3780

cuuacuauua auagaaucuu uaaaggggca gcuagcgaac aauccgagac agugcagccg     3840

ggagaugaga uacuccagcu gggcgguacc gccaugcagg gguugacucg cuucgaggcu     3900

uggaacauua ucaaggcacu gcccgacgga ccaguaacca uugucaucag gcguaaauca     3960

uuacaaagca aggaaacaac ggccgccggc gauucuuga                            3999


<210>  4230
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4230
auggagagcc acagcagagc cggcaagagc agaaagagcg ccaaguucag aagcaucagc       60

agaagccuga ugcugugcaa cgccaagacc agcgacgacg gcagcagccc cgacgagaag      120

uaccccgacc ccuucgagau cagccuggcc cagggcaagg agggcaucuu ccacagcagc      180

gugcagcugg ccgacaccag cgaggccggc cccagcagcg ugcccgaccu ggcccuggcc      240

agcgaggccg cccagcugca ggccgccggc aacgacagag gcaagaccug cagaagaauc      300

uucuucauga aggagagcag caccgccagc agcagagaga agcccggcaa gcuggaggcc      360

cagagcagca acuuccuguu ccccaaggcc ugccaccaga gagccagaag caacagcacc      420

agcgugaacc ccuacugcac cagagagauc gacuucccca ugaccaagaa gagcgccgcc      480

cccaccgaca gacagcccua cagccugugc agcaacagaa agagccugag ccagcagcug      540

gacugccccg ccggcaaggc cgccggcacc agcagaccca ccagaagccu gagcaccgcc      600

cagcuggugc agcccagcgg cggccugcag gccagcguga ucagcaacau cgugcugaug      660

aagggccagg ccaagggccu gggcuucagc aucgugggcg gcaaggacag caucuacggc      720

cccaucggca ucuacgugaa gaccaucuuc gccggcggcg ccgccgccgc cgacggcaga      780

cugcaggagg gcgacgagau ccuggagcug aacggcgaga gcauggccgg ccugacccac      840

caggacgccc ugcagaaguu caagcaggcc aagaagggcc ugcugacccu gaccgugaga      900

accagacuga ccgccccccc cagccugugc agccaccuga gccccccccu gugcagaagc      960

cugagcagca gcaccugcau caccaaggac agcagcagcu ucgcccugga gagccccagc     1020

gcccccauca gcaccgccaa gcccaacuac agaaucaugg uggaggugag ccugcagaag     1080

gaggccggcg ugggccuggg caucggccug ugcagcgugc ccuacuucca gugcaucagc     1140

ggcaucuucg ugcacacccu gagccccggc agcguggccc accuggacgg cagacugaga     1200

ugcggcgacg agaucgugga gaucagcgac agccccgugc acugccugac ccugaacgag     1260

guguacacca uccugagcca cugcgacccc ggccccgugc ccaucaucgu gagcagacac     1320

cccgaccccc aggugagcga gcagcagcug aaggaggccg uggcccaggc cguggagaac     1380

accaaguucg gcaaggagag acaccagugg agccuggagg gcgugaagag acuggagagc     1440

agcuggcacg gcagacccac ccuggagaag gagagagaga agaacagcgc ccccccccac     1500

agaagagccc agaaggugau gaucagaagc agcagcgaca gcagcuacau gagcggcagc     1560

cccggcggca gccccggcag cggcagcgcc gagaagccca gcagcgacgu ggacaucagc     1620

acccacagcc ccagccugcc ccuggccaga gagcccgugg ugcugagcau cgccagcagc     1680

agacugcccc aggagagccc cccccugccc gagagcagag acagccaccc cccccugaga     1740

cugaagaaga gcuucgagau ccuggugaga aagcccauga gcagcaagcc caagcccccc     1800

cccagaaagu acuucaagag cgacagcgac ccccagaaga gccuggagga gagagagaac     1860

agcagcugca gcagcggcca cacccccccc accugcggcc aggaggccag agagcugcug     1920

ccccugcugc ugccccagga ggacaccgcc ggcagaagcc ccagcgccag cgccggcugc     1980

cccggccccg gcaucggccc ccagaccaag agcagcaccg agggcgagcc cggcuggaga     2040

agagccagcc ccgugaccca gaccagcccc aucaagcacc cccugcugaa gagacaggcc     2100

agaauggacu acagcuucga caccaccgcc gaggaccccu gggugagaau cagcgacugc     2160

aucaagaacc uguucagccc caucaugagc gagaaccacg gccacaugcc ccugcagccc     2220

aacgccagcc ugaacgagga ggagggcacc cagggccacc ccgacggcac cccccccaag     2280

cuggacaccg ccaacggcac ccccaaggug uacaagagcg ccgacagcag caccgugaag     2340

aagggccccc ccguggcccc caagcccgcc ugguucagac agagccugaa gggccugaga     2400

aacagagcca gcgaccccag aggccugccc gaccccgccc ugagcaccca gcccgccccc     2460

gccagcagag agcaccuggg cagccacauc agagccagca gcagcagcag cagcaucaga     2520

cagagaauca gcagcuucga gaccuucggc agcagccagc ugcccgacaa gggcgcccag     2580

agacugagcc ugcagcccag cagcggcgag gccgccaagc cccugggcaa gcacgaggag     2640

ggcagauuca gcggccugcu gggcagaggc gccgccccca cccuggugcc ccagcagccc     2700

gagcaggugc ugagcagcgg cagccccgcc gccagcgagg ccagagaccc cggcgugagc     2760

gagagccccc cccccggcag acagcccaac cagaagaccc ugccccccgg ccccgacccc     2820

cugcugagac ugcugagcac ccaggccgag gagagccagg gccccgugcu gaagaugccc     2880

agccagagag ccagaagcuu cccccugacc agaagccaga gcugcgagac caagcugcug     2940

gacgagaaga ccagcaagcu guacagcauc agcagccagg ugagcagcgc cgugaugaag     3000

agccugcugu gccugcccag cagcaucagc ugcgcccaga cccccugcau ccccaaggag     3060

ggcgccagcc ccaccagcag cagcaacgag gacagcgccg ccaacggcag cgccgagacc     3120

agcgcccugg acaccggcuu cagccugaac cugagcgagc ugagagagua caccgagggc     3180

cugaccgagg ccaaggagga cgacgacggc gaccacagca gccugcagag cggccagagc     3240

gugaucagcc ugcugagcag cgaggagcug aagaagcuga ucgaggaggu gaaggugcug     3300

gacgaggcca cccugaagca gcuggacggc auccacguga ccauccugca caaggaggag     3360

ggcgccggcc ugggcuucag ccuggccggc ggcgccgacc uggagaacaa ggugaucacc     3420

gugcacagag uguuccccaa cggccuggcc agccaggagg gcaccaucca gaagggcaac     3480

gaggugcuga gcaucaacgg caagagccug aagggcacca cccaccacga cgcccuggcc     3540

auccugagac aggccagaga gcccagacag gccgugaucg ugaccagaaa gcugaccccc     3600

gaggccaugc ccgaccugaa cagcagcacc gacagcgccg ccagcgccag cgccgccagc     3660

gacgugagcg uggagagcac cgccgaggcc accgugugca ccgugacccu ggagaagaug     3720

agcgccggcc ugggcuucag ccuggagggc ggcaagggca gccugcacgg cgacaagccc     3780

cugaccauca acagaaucuu caagggcgcc gccagcgagc agagcgagac cgugcagccc     3840

ggcgacgaga uccugcagcu gggcggcacc gccaugcagg gccugaccag auucgaggcc     3900

uggaacauca ucaaggcccu gcccgacggc cccgugacca ucgugaucag aagaaagagc     3960

cugcagagca aggagaccac cgccgccggc gacagcuga                            3999


<210>  4231
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4231
auggagagcc acuccagagc cggcaagucu cggaaaagcg cuaaguuccg cuccaucucu       60

agaagccuga ugcucugcaa cgccaaaacc uccgacgaug ggucuagccc cgacgaaaag      120

uacccugauc cguuugagau uucccuggcg cagggaaaag aaggcaucuu ccauagcucu      180

gugcaacuug cugacacauc cgaggccggg cccagcucug ucccugaucu ggcccucgcu      240

uccgaagccg cucagcugca ggccgcggga aaugaccggg gcaagacgug ucgcagaauc      300

uuuuucauga aggagagcuc uaccgccucc agccgggaga aacccgggaa acuugaagcu      360

caguccucua acuuucuguu cccuaaggcc ugccaccaac gcgcuagaag caauuccaca      420

agcguuaacc ccuauuguac ccgggagauu gauuuuccua ugacaaagaa aucugccgcg      480

ccgaccgacc gccagcccua cucccucugc agcaauagaa agucucugag ccagcagcug      540

gauuguccug ccggaaaggc ugccggcaca ucccggccca cccgcucucu cagcacggcu      600

caacuggugc agccuuccgg cgggcuucag gccagcguga uuucuaacau cguccugaug      660

aaaggacagg ccaagggccu cggguucucc aucgugggag gcaaagacag cauuuauggg      720

cccaucggaa uuuacguuaa gaccaucuuu gcuggcggcg cggccgcugc cgaugggaga      780

cugcaagaag gagacgagau ucuugagcug aauggcgaau cuauggccgg gcucacacau      840

caggaugcuc ugcagaaauu caagcaagcc aaaaagggac ugcucacccu gacagugcgg      900

acccgccuua cggcgccgcc uucccugugc agccaccucu ccccuccccu guguagaucu      960

cuuagcuccu cuacaugcau caccaaggac agcuccagcu uugcucugga gucucccucc     1020

gcccccauua gcacagccaa accuaacuau cggaucaugg ucgaaguguc ucuccagaag     1080

gaggcuggcg uugggcuggg aaucggccug uguuccgugc cguacuucca gugcauuagc     1140

ggcaucuuug uccauacccu cucucccggg agcguggccc accuggacgg aagacuucgc     1200

uguggcgaug aaauugugga gaucuccgac agcccugucc acugccugac ccucaaugag     1260

guuuauacaa uucugucuca uugcgauccc gggccugugc ccaucaucgu gucccggcac     1320

ccggacccuc aggucagcga acaacagcuu aaagaggcug uggcccaggc gguugaaaac     1380

acgaaguucg gaaaagagag acaucagugg ucccuggaag gcgugaagcg ccucgagucu     1440

agcuggcacg ggcggcccac ccuggagaag gaaagagaga aaaauuccgc cccuccccac     1500

cgccgggcuc aaaaggucau gauuagaucu agcuccgauu cuagcuacau guccggcagc     1560

ccuggaggcu cucccggguc cggaagcgcc gaaaaaccgu cuuccgacgu ggauaucagc     1620

acacauucuc cuucccugcc ccucgcucgc gagcccguug ugcugagcau ugccuccagc     1680

cggcuuccuc aggaaucucc gccccugccu gagagcagag acucccaucc cccucuccgc     1740

cugaagaaau cuuucgagau ccugguccgg aagcccauga gcuccaagcc uaaacccccg     1800

ccuagaaagu acuuuaaauc ugauagcgac ccccagaagu cccuugagga gcgggaaaac     1860

ucuagcuguu ccagcggcca caccccuccc acaugcgggc aggaggcgcg cgagcuccug     1920

ccgcugcucc ugccucaaga agauaccgcc ggaagaucuc ccuccgcuag cgccggcugu     1980

ccugggcccg gcauuggacc ccagacgaaa ucuuccacag agggcgaacc uggguggcgg     2040

agagcuagcc cggugaccca gaccuccccc aucaagcacc cucuucugaa gcgccaggcc     2100

cggauggacu auucuuucga cacaaccgcc gaggaucccu gggucagaau cagcgacugc     2160

auuaaaaauc ucuuuucccc uaucaugagc gaaaaccaug gacacaugcc ccugcaaccu     2220

aaugcuucuc ugaacgagga ggaaggcaca caggggcacc cggauggaac gcccccuaaa     2280

cuugacaccg cgaacggcac acccaaggug uacaaguccg ccgauagcuc uaccguuaaa     2340

aaggggccuc ccguggcucc gaaaccugcc ugguuccgcc agagccucaa gggccugaga     2400

aaucgggccu ccgacccccg cggacugccc gauccugcuc ucucuacaca acccgccccu     2460

gcgagcagag agcaucuggg cucccacauu cgggcuucua gcuccagcuc cuccauccgc     2520

cagagaauua gcuccuuuga aaccuucggg ucuagccagc uuccggacaa gggagcccag     2580

cggcuguccc uccaacccuc uagcggcgag gccgcuaaac cucuggggaa gcaugaagag     2640

ggacgcuuuu ccggccugcu ugggagaggc gccgcgccca cgcucguccc ucagcagccc     2700

gaacaggugc ugagcucugg auccccggcu gccagcgaag cccgggaucc uggcguuucu     2760

gagucucccc cucccgggcg ccaaccuaac cagaaaaccc ugcccccggg accugacccc     2820

cuccugagac uucugagcac acaggcugaa gagucucagg gccccgugcu caagaugccu     2880

agccaacggg ccagauccuu cccgcugacc cgcucucaga gcugugaaac aaaacugcuu     2940

gaugagaaga ccuccaagcu cuauagcauc uccucucagg ucagcuccgc ugugaugaaa     3000

ucucugcugu gccuccccag cuccauuucu ugugcccaaa cgccuugcau ccccaaggag     3060

ggggcgagcc cuacauccag cucuaaugaa gacuccgccg cuaacggaag cgccgagacc     3120

ucugcucugg auacaggcuu uucccuuaau cugagcgaac uccgggagua caccgagggc     3180

cugaccgaag ccaaagagga cgacgauggg gaccacucuu cccugcagag cggacagucc     3240

gugaucagcc uucugucuag cgaggaacuc aagaaacuga uugaagaggu uaagguccuc     3300

gaugaggcca cacugaagca gcuugacggc auccacguga cgauucugca uaaagaagag     3360

ggggcuggac ucggcuucuc ccuggcuggg ggagccgauc uggaaaacaa ggugaucacc     3420

guccacagag uguuucccaa uggccuugcu ucucaagagg gcacaauuca gaaagggaac     3480

gaaguucuga gcaucaaugg aaagucccuc aaaggcacca cacaucacga cgcccuggcc     3540

auccuccgcc aggcucggga gccuagacag gccgugauug ucacccgcaa gcugacgccg     3600

gaggcgaugc ccgaucuuaa cucuagcaca gacuccgcug ccucugccag cgcugccucc     3660

gaugugagcg uugaaucuac cgcggaggcu accgugugua cagucacccu ggaaaagaug     3720

uccgccgggc ucggauucag ccuggagggc gggaaaggau cucugcaugg cgacaagccu     3780

cuuacaauca aucggauuuu uaaaggcgcc gcuuccgaac aaagcgagac ggugcagccc     3840

ggggaugaga uccugcagcu cggaggcacc gccaugcagg ggcugacaag auucgaagcg     3900

uggaacauua ucaaggcccu cccugacgga cccguuacca ucgugauucg ccggaaaucc     3960

cugcaaucua aggagacaac cgcggccggc gauagcuga                            3999


<210>  4232
<211>  3999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-16__Homo_sapiens__CCDS42069.1

<400>  4232
auggaaucac auucaagagc ggguaaaucu cgaaaaucug cgaaauuccg cuccauuuca       60

agaagucuaa uguuaugcaa cgcgaaaaca ucggaugacg gcagcucgcc agaugaaaaa      120

uauccagauc ccuucgaaau uucguuagcc caaggaaagg aaggaaucuu ucauagcuca      180

guucaacucg cugauacuuc ugaagccgga ccuagcucag uaccggaccu cgcucucgcu      240

agcgaagcug cacaacugca agccgcaggc aaugaucgag gaaaaacuug uaggagaauc      300

uuuuuuauga aggagagcag uacugccuca ucuagagaaa aaccuggaaa auuagaagca      360

caaucgucaa auuuuuuguu cccuaaagca ugucaccagc gagcucgauc aaauucuaca      420

ucagucaacc cauacuguac acgagaaaua gauuuuccga ugacuaaaaa aucggcagcu      480

ccaacugauc gacaaccuua uucacuaugc ucaaauagaa aaucucugag ucaacaacuu      540

gauuguccag ccggaaaagc cgccggaacc ucaaggccga cccgaagccu aucuacugca      600

caauuaguac aaccaucagg ggguuuacaa gccucgguaa uuucaaauau aguguuaaug      660

aaaggacaag caaagggguu aggcuucagc auugucggug gaaaggauag uauauauggc      720

ccgauaggga uauacguaaa aacaauuuuu gcugggggug ccgccgccgc ugauggaaga      780

cuccaagaag gagacgagau acuagaacua aacggcgaga gcauggccgg auugacccac      840

caagacgcuc uacaaaaauu uaaacaagcu aaaaaagggc ucuuaacauu aacgguaagg      900

acaagacuaa cagcaccgcc uucgcuaugc ucacaccuua guccucccuu auguagaucu      960

cucuccaguu caacauguau cacaaaagau aguucaucuu uugcacuaga auccccuagu     1020

gcucccaucu caacugccaa accaaauuau agaauuaugg uagaaguaag cuuacaaaaa     1080

gaggcagggg ugggacuagg aauaggauua ugcagcgucc ccuacuucca augcauaucc     1140

ggaaucuucg uccauacacu aucuccuggc ucaguggcac accucgaugg aagacuuaga     1200

uguggugaug aaauuguaga aauauccgau aguccuguac acugucuaac uuuaaaugaa     1260

guuuacacua uacuuucuca cugugaucca ggaccagugc cuaucauagu aucucgacac     1320

ccagauccac aaguaucaga acaacaauug aaagaagcag uagcacaagc aguggaaaau     1380

acuaaauuug gaaaagaaag acaccagugg ucauuagaag gcgucaaacg cuuggaaucu     1440

agcuggcaug gcagaccaac auuagagaaa gagagagaaa agaacuccgc accuccccau     1500

agaagagcac agaaaguaau gauccguagc agcagcgaca guucauacau gucagguagu     1560

ccaggaggua guccaggaag uggauccgca gaaaaaccau caucagaugu cgacauaagu     1620

acccauaguc caucacuucc ccuagcaagg gaaccuguug uauuaucaau agcauccagc     1680

cgauuacccc aagaaucacc accacuucca gaaucuagag auucacaccc ccccuuacgc     1740

uuaaaaaaau cguuugaaau uuuaguacgc aaaccaaugu cuucuaaacc aaaaccacca     1800

ccuagaaaau auuuuaaguc agauucagac ccacaaaaau cuuuagaaga acgcgaaaau     1860

aguucauguu cauccggcca cacaccaccc acguguggac aagaagcuag agaacuauua     1920

ccacuucuuc uaccccaaga agauacagca gguagaucac caucugcauc agcgggcugu     1980

ccaggcccgg gaauuggucc ucaaaccaaa ucaaguacag aaggagaacc agguuggaga     2040

agagcaaguc cagucacaca aacaagcccu auaaaacauc cuuuacuaaa gcgacaggcg     2100

cgaauggacu auuccuuuga uacuacagcu gaagacccau ggguccgaau aucugacugc     2160

auaaagaauu uguuuagucc aauaauguca gaaaaccaug gacauaugcc guuacaacca     2220

aacgcaucau uaaacgaaga agaaggaacu caaggucauc cagacgguac uccacccaaa     2280

uuagauacag caaauggaac uccaaaagua uauaaaucag cagauucaag uaccguaaaa     2340

aaggguccac caguagcacc caaaccugca ugguucaggc aaaguuugaa aggccuccga     2400

aaccgagcca gcgacccuag aggacugcca gauccugcuc uaucgacuca accagcucca     2460

gcauccaggg aacacuuagg uucacacauu cgagcuucua guaguuccuc auccauuagg     2520

caacgaauau cuaguuucga aacauuugga aguucccaac uaccagacaa aggugcucaa     2580

cgcuuguccc uacaacccuc cucaggcgaa gcagcaaaac cauuaggcaa acacgaagaa     2640

gguagauuca guggucuacu agggagagga gcagcaccca cacucguacc acaacaacca     2700

gaacaaguuu uauccagugg gucacccgca gcaucagaag cacgagaucc cggcguuagu     2760

gagucuccac cuccaggcag acagccuaau caaaaaacac uaccuccugg uccugaucca     2820

cuacuaagau uauuaucaac ccaagcugaa gaaucucaag gcccgguuuu gaaaaugccu     2880

ucgcagaggg caaggucauu uccucuuacc cgaucucaaa gcugcgagac aaaacuacua     2940

gaugaaaaaa ccuccaaauu auauuccaua ucaucacagg uaucuagugc aguuaugaaa     3000

ucuuuacucu gucuaccgag uucaauuuca ugcgcucaaa caccauguau ccccaaagaa     3060

ggcgcaucac cgacaucauc caguaaugaa gauucugcug caaacggauc cgcagaaaca     3120

ucugcauuag acaccggcuu uucccuaaau uuaagugaac uaagagaaua cacagaggga     3180

cuaacagaag caaaggaaga cgacgauggu gaucauucau cccuacaauc cgggcagucc     3240

guaauaaguc uauuaucauc ugaagaauua aaaaagcuaa uugaagaagu aaaaguauua     3300

gaugaagcua cacuuaaaca auuagacgga auccacguua ccauuuugca uaaagaagag     3360

ggugcaggac uagguuucag ucuagcaggu ggcgcagauu uagaaaauaa gguuauaacc     3420

guacauagag ucuucccaaa cggcuuagcc ucucaagaag gaacaaucca aaaaggaaau     3480

gaaguucuau ccaucaacgg aaaaagccua aaaggaacaa cacaccauga cgcacuugcc     3540

auacuaagac aagcaagaga accaagacaa gcaguaauag uaacgcguaa auuaacuccu     3600

gaagcaaugc ccgaucucaa uucgaguacu gacucagcgg caagcgccuc agccgcaagu     3660

gaugucucag uagaaucaac agccgaagcg acaguuugca caguaacacu cgaaaaaaug     3720

agugcaggac ugggauuuuc auuagaagga ggcaagggua gccuacacgg agauaaacca     3780

cuaacaauaa auagaauuuu uaaaggagcu gcaucagaac aaagugaaac cguacaaccg     3840

ggugacgaaa uucuacaauu aggugggaca gccaugcaag gauuaacuag guucgaagca     3900

uggaacauaa uuaaagcucu cccggacgga ccagucacua uaguaauaag aagaaaauca     3960

cuccaaucga aagaaacaac ugcggcgggg gacuccuga                            3999


<210>  4233
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17A__Homo_sapiens__Q16552

<400>  4233

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  4234
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17A__Homo_sapiens__AAC50341

<400>  4234
augacuccug ggaagaccuc auugguguca cugcuacugc ugcugagccu ggaggccaua       60

gugaaggcag gaaucacaau cccacgaaau ccaggaugcc caaauucuga ggacaagaac      120

uucccccgga cugugauggu caaccugaac auccauaacc ggaauaccaa uaccaauccc      180

aaaagguccu cagauuacua caaccgaucc accucaccuu ggaaucucca ccgcaaugag      240

gacccugaga gauaucccuc ugugaucugg gaggcaaagu gccgccacuu gggcugcauc      300

aacgcugaug ggaacgugga cuaccacaug aacucugucc ccauccagca agagauccug      360

guccugcgca gggagccucc acacugcccc aacuccuucc ggcuggagaa gauacuggug      420

uccgugggcu gcaccugugu caccccgauu guccaccaug uggccuaa                   468


<210>  4235
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4235
augacccccg gcaagaccag ccuggugucc cuccugcugc uccugagccu ggaggccauc       60

gucaaggccg ggaucaccau cccgcgcaac cccggcugcc ccaacuccga ggacaagaac      120

uucccccgga ccgugauggu gaaccucaac auccacaacc gcaacaccaa caccaacccg      180

aagcggagcu ccgacuacua caaccgcagc acgucccccu ggaaccugca ccggaacgag      240

gaccccgagc gcuaccccag cgucaucugg gaggcgaagu gccggcaccu ggggugcauc      300

aacgccgacg gcaacgugga cuaccacaug aacuccgugc cgauccagca ggagauccuc      360

guccugcgcc gggagccgcc ccacugcccc aacagcuucc gccuggagaa gauccucgug      420

uccguggggu gcacgugcgu cacccccauc gugcaccacg uggccuga                   468


<210>  4236
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4236
augacccccg gcaagaccuc ccucgucucc cuccuccucc uccucucccu cgaggccauc       60

gucaaggccg gcaucaccau cccccgcaac cccggcugcc ccaacuccga ggacaagaac      120

uucccccgca ccgucauggu caaccucaac auccacaacc gcaacaccaa caccaacccc      180

aagcgcuccu ccgacuacua caaccgcucc accucccccu ggaaccucca ccgcaacgag      240

gaccccgagc gcuaccccuc cgucaucugg gaggccaagu gccgccaccu cggcugcauc      300

aacgccgacg gcaacgucga cuaccacaug aacuccgucc ccauccagca ggagauccuc      360

guccuccgcc gcgagccccc ccacugcccc aacuccuucc gccucgagaa gauccucguc      420

uccgucggcu gcaccugcgu cacccccauc guccaccacg ucgccuga                   468


<210>  4237
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4237
augacccccg gcaagacaag ccuggugucc cuccuucugu uguuaucucu ggaggccauc       60

gucaaagcug ggauuacuau accuagaaac ccaggaugcc ccaauucaga agacaagaac      120

uucccgagga cgguuauggu gaaucuaaac auccacaauc ggaacaccaa uacaaacccu      180

aaacgcagua gcgauuacua uaaucgaucc acuucuccau ggaaccucca ucguaaugag      240

gaccccgaaa gauacccuuc gguaauuugg gaggcaaagu guaggcaccu ggguugcauc      300

aacgccgaug gcaaugugga cuaucauaug aacucagucc caauucagca agaaauccuu      360

gugcugcggc gcgagccccc ucacugucca aauagcuuua gauuggagaa aauacucguu      420

aguguggggu gcaccugugu cacaccgauc gugcaucacg uagcguga                   468


<210>  4238
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4238
augacccccg gcaagaccag ccuggugagc cugcugcugc ugcugagccu ggaggccauc       60

gugaaggccg gcaucaccau ccccagaaac cccggcugcc ccaacagcga ggacaagaac      120

uuccccagaa ccgugauggu gaaccugaac auccacaaca gaaacaccaa caccaacccc      180

aagagaagca gcgacuacua caacagaagc accagccccu ggaaccugca cagaaacgag      240

gaccccgaga gauaccccag cgugaucugg gaggccaagu gcagacaccu gggcugcauc      300

aacgccgacg gcaacgugga cuaccacaug aacagcgugc ccauccagca ggagauccug      360

gugcugagaa gagagccccc ccacugcccc aacagcuuca gacuggagaa gauccuggug      420

agcgugggcu gcaccugcgu gacccccauc gugcaccacg uggccuga                   468


<210>  4239
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4239
augacccccg gcaagacaag ccuggugucc cuccugcuuc ugcucucucu ggaggccauc       60

gucaaagcug ggauuacgau cccuagaaac ccgggaugcc ccaauagcga agacaagaac      120

uucccucgga ccguuauggu gaaucuuaac auucacaauc gcaacacaaa uaccaacccc      180

aaaagauccu cugauuacua uaaucggagc acauccccuu ggaaccugca ucgcaaugag      240

gaccccgaaa gauacccuuc ugugaucugg gaggccaagu gucggcaccu cggcugcauu      300

aacgcggaug ggaaugucga cuaucauaug aacagcgugc cgauccagca agaaauccug      360

guucugcgca gagagccccc ucacuguccc aauuccuuuc ggcucgagaa aauucuggug      420

agcgucggau gcaccugugu gacaccuauc guucaucacg uggcuuga                   468


<210>  4240
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17A__Homo_sapiens__AAC50341

<400>  4240
augacaccag gaaaaacauc acuaguaucc cuauuacuac uacuaucacu agaagcaaua       60

guaaaagcag gaauaacaau accaagaaau ccaggaugcc caaacucaga agacaaaaac      120

uucccaagaa caguaauggu aaaccuaaac auacacaaca gaaacacaaa cacaaaccca      180

aaaagaucau ccgacuauua caacagauca acauccccau ggaaccuaca cagaaacgaa      240

gacccagaaa gauacccauc aguaauaugg gaagcaaaau gcagacaccu aggaugcaua      300

aacgcagacg gaaacguaga cuaccacaug aacuccguac caauacaaca agaaauacua      360

guauuaagac gagaaccacc acacugccca aacucauuca gacuagaaaa aauacuagua      420

ucaguaggau gcacaugcgu aacaccaaua guacaccacg uagcauaa                   468


<210>  4241
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17B__Homo_sapiens__Q9NRM6

<400>  4241

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  4242
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17B__Homo_sapiens__AAH00980

<400>  4242
augucgcucg ugcugcuaag ccuggccgcg cugugcagga gcgccguacc ccgagagccg       60

accguucaau guggcucuga aacugggcca ucuccagagu ggaugcuaca acaugaucua      120

aucccgggag acuugaggga ccuccgagua gaaccuguua caacuagugu ugcaacaggg      180

gacuauucaa uuuugaugaa uguaagcugg guacuccggg cagaugccag cauccgcuug      240

uugaaggcca ccaagauuug ugugacgggc aaaagcaacu uccaguccua cagcugugug      300

aggugcaauu acacagaggc cuuccagacu cagaccagac ccucuggugg uaaauggaca      360

uuuuccuaca ucggcuuccc uguagagcug aacacagucu auuucauugg ggcccauaau      420

auuccuaaug caaauaugaa ugaagauggc ccuuccaugu cugugaauuu caccucacca      480

ggcugccuag accacauaau gaaauauaaa aaaaagugug ucaaggccgg aagccugugg      540

gauccgaaca ucacugcuug uaagaagaau gaggagacag uagaagugaa cuucacaacc      600

acuccccugg gaaacagaua cauggcucuu auccaacaca gcacuaucau cggguuuucu      660

cagguguuug agccacacca gaagaaacaa acgcgagcuu caguggugau uccagugacu      720

ggggauagug aaggugcuac ggugcagcug acuccauauu uuccuacuug uggcagcgac      780

ugcauccgac auaaaggaac aguugugcuc ugcccacaaa caggcguccc uuucccucug      840

gauaacaaca aaagcaagcc gggaggcugg cugccucucc uccugcuguc ucugcuggug      900

gccacauggg ugcugguggc agggaucuau cuaaugugga ggcacgaaag gaucaagaag      960

acuuccuuuu cuaccaccac acuacugccc cccauuaagg uucuuguggu uuacccaucu     1020

gaaauauguu uccaucacac aauuuguuac uucacugaau uucuucaaaa ccauugcaga     1080

agugagguca uccuugaaaa guggcagaaa aagaaaauag cagagauggg uccagugcag     1140

uggcuugcca cucaaaagaa ggcagcagac aaagucgucu uccuucuuuc caaugacguc     1200

aacagugugu gcgaugguac cuguggcaag agcgagggca gucccaguga gaacucucaa     1260

gaccucuucc cccuugccuu uaaccuuuuc ugcagugauc uaagaagcca gauucaucug     1320

cacaaauacg ugguggucua cuuuagagag auugauacaa aagacgauua caaugcucuc     1380

agugucugcc ccaaguacca ccucaugaag gaugccacug cuuucugugc agaacuucuc     1440

caugucaagc agcagguguc agcaggaaaa agaucacaag ccugccacga uggcugcugc     1500

uccuuguag                                                             1509


<210>  4243
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4243
augagccugg ugcuccuguc ccuggccgcc cucugccgca gcgcggugcc ccgggagccg       60

accgugcagu gcggcuccga gaccgggccc agccccgagu ggaugcugca gcacgaccug      120

auccccggcg accuccgcga ccugcgggug gagccgguca cgaccuccgu ggccaccggg      180

gacuacagca uccugaugaa cguguccugg guccuccgcg ccgacgccag cauccggcug      240

cugaaggcca ccaagaucug cgugacgggc aaguccaacu uccagagcua cuccugcgug      300

cgcugcaacu acaccgaggc guuccagacc cagacccggc ccagcggggg caaguggacg      360

uucuccuaca ucggcuuccc cgucgagcuc aacaccgugu acuucaucgg ggcccacaac      420

auccccaacg ccaacaugaa cgaggacggc ccgagcaugu ccgugaacuu caccagcccc      480

gggugccugg accacaucau gaaguacaag aagaagugcg ucaaggccgg cucccugugg      540

gaccccaaca ucaccgcgug caagaagaac gaggagacgg uggaggugaa cuucaccacc      600

acgccccucg ggaaccgcua cauggcccug auccagcaca gcaccaucau cggcuucucc      660

caggucuucg agccgcacca gaagaagcag acccgggcca gcguggugau ccccgucacc      720

ggcgacagcg agggggccac cgugcagcug acgcccuacu ucccgaccug cggcuccgac      780

ugcauccgcc acaaggggac cgugguccuc ugcccccaga ccggcgugcc cuucccccug      840

gacaacaaca agagcaagcc cggcgggugg cugccgcucc ugcugcucuc ccugcuggug      900

gccacguggg uccucguggc gggcaucuac cugauguggc ggcacgagcg caucaagaag      960

accagcuucu ccaccaccac gcugcucccg cccaucaagg uccugguggu guaccccagc     1020

gagaucugcu uccaccacac caucugcuac uucaccgagu uccugcagaa ccacugccgg     1080

uccgagguca uccucgagaa guggcagaag aagaagaucg ccgagauggg gcccgugcag     1140

uggcuggcca cccagaagaa ggccgccgac aagguggucu uccugcucag caacgacgug     1200

aacuccgugu gcgacggcac gugcggcaag agcgaggggu cccccagcga gaacucccag     1260

gaccuguucc cccuggcguu caaccucuuc ugcagcgacc ugcgcuccca gauccaccuc     1320

cacaaguacg ucguggugua cuuccgggag aucgacacca aggacgacua caacgcccug     1380

agcgucugcc ccaaguacca ccugaugaag gacgccaccg ccuucugcgc cgagcugcuc     1440

cacgugaagc agcaggucuc cgcgggcaag cgcagccagg ccugccacga cgggugcugc     1500

ucccuguga                                                             1509


<210>  4244
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4244
augucccucg uccuccucuc ccucgccgcc cucugccgcu ccgccguccc ccgcgagccc       60

accguccagu gcggcuccga gaccggcccc ucccccgagu ggaugcucca gcacgaccuc      120

auccccggcg accuccgcga ccuccgcguc gagcccguca ccaccuccgu cgccaccggc      180

gacuacucca uccucaugaa cgucuccugg guccuccgcg ccgacgccuc cauccgccuc      240

cucaaggcca ccaagaucug cgucaccggc aaguccaacu uccaguccua cuccugcguc      300

cgcugcaacu acaccgaggc cuuccagacc cagacccgcc ccuccggcgg caaguggacc      360

uucuccuaca ucggcuuccc cgucgagcuc aacaccgucu acuucaucgg cgcccacaac      420

auccccaacg ccaacaugaa cgaggacggc cccuccaugu ccgucaacuu caccuccccc      480

ggcugccucg accacaucau gaaguacaag aagaagugcg ucaaggccgg cucccucugg      540

gaccccaaca ucaccgccug caagaagaac gaggagaccg ucgaggucaa cuucaccacc      600

accccccucg gcaaccgcua cauggcccuc auccagcacu ccaccaucau cggcuucucc      660

caggucuucg agccccacca gaagaagcag acccgcgccu ccgucgucau ccccgucacc      720

ggcgacuccg agggcgccac cguccagcuc acccccuacu uccccaccug cggcuccgac      780

ugcauccgcc acaagggcac cgucguccuc ugcccccaga ccggcguccc cuucccccuc      840

gacaacaaca aguccaagcc cggcggcugg cucccccucc uccuccucuc ccuccucguc      900

gccaccuggg uccucgucgc cggcaucuac cucauguggc gccacgagcg caucaagaag      960

accuccuucu ccaccaccac ccuccucccc cccaucaagg uccucgucgu cuaccccucc     1020

gagaucugcu uccaccacac caucugcuac uucaccgagu uccuccagaa ccacugccgc     1080

uccgagguca uccucgagaa guggcagaag aagaagaucg ccgagauggg ccccguccag     1140

uggcucgcca cccagaagaa ggccgccgac aaggucgucu uccuccucuc caacgacguc     1200

aacuccgucu gcgacggcac cugcggcaag uccgagggcu cccccuccga gaacucccag     1260

gaccucuucc cccucgccuu caaccucuuc ugcuccgacc uccgcuccca gauccaccuc     1320

cacaaguacg ucgucgucua cuuccgcgag aucgacacca aggacgacua caacgcccuc     1380

uccgucugcc ccaaguacca ccucaugaag gacgccaccg ccuucugcgc cgagcuccuc     1440

cacgucaagc agcaggucuc cgccggcaag cgcucccagg ccugccacga cggcugcugc     1500

ucccucuga                                                             1509


<210>  4245
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4245
augagccugg ugcuccuuuc ccuggccgcu uugugcagau cugcaguccc cagggagccu       60

accguucagu guggcucaga aacagggcca aguccggagu ggauguuaca acacgaccug      120

auccccggag aucuacggga ccuccgcgug gaaccuguaa cuacgagcgu ggccaccggu      180

gauuacucca uucugaugaa cgucucuugg gugcuucgag cggacgcuuc gauacgucug      240

uugaaggcca caaaaaucug cguuacuggc aagucaaauu uccagagcua uaguugugug      300

agaugcaacu acaccgaggc auuucagaca cagaccaggc cauccggggg aaaauggacu      360

uucucuuaua uuggcuuucc cgucgaacuc aauacagugu acuucaucgg ugcccauaac      420

auuccuaaug cuaacaugaa ugaggauggg ccaagcaugu ccguaaacuu uaccucaccc      480

ggaugucugg accacaucau gaaguauaaa aagaagugcg uuaaagcagg cagucugugg      540

gauccuaaua uaacggccug uaagaaaaac gaggaaacug uggaggucaa uuucaccaca      600

acuccacucg gcaaccggua cauggcuuua auccaacaua gcaccauuau cggguuuucu      660

cagguguucg aaccgcacca gaagaaacag acacgcgccu ccguggucau ucccguuacc      720

ggagacucag agggugcgac ggugcaacug acuccuuauu uuccaacaug cggcagcgau      780

uguaucagac auaaggggac cguagugcuu ugcccccaga cuggaguccc uuucccauug      840

gacaauaaca agaguaaacc cggcgguugg cugccgcuac uccugcuuuc ucuguuggug      900

gcaacauggg uucucguggc cgggauauac cugaugugga ggcacgagcg gauuaagaaa      960

accuccuuua gcacgaccac auuacugccu cccaucaagg uccucguggu auacccaucg     1020

gaaauuuguu uccaccauac uaucugcuau uuuaccgagu uccuucagaa ucacugccgc     1080

ucugaaguua uccuggagaa auggcagaag aaaaagauug cugaaauggg accugugcaa     1140

ugguuggcca cacagaagaa agcagcugau aaggucgugu uccuacuguc caacgacguc     1200

aacucagugu gugauggcac uugcggcaaa agugagggga gccccuccga aaauucucag     1260

gaccucuuuc cacuggccuu caaccuguuu uguagcgacc uucgaucaca aauacauuug     1320

cacaaguacg uugugguaua uuucagagag aucgauacca aagacgauua caaugcgcuc     1380

agugucugcc ccaaguauca ccugaugaag gacgccacag cauuuugugc ugaguuacug     1440

caugugaaac agcagguuuc cgccggaaag aggagccagg cuugccacga ugguuguugc     1500

ucucuauga                                                             1509


<210>  4246
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4246
augagccugg ugcugcugag ccuggccgcc cugugcagaa gcgccgugcc cagagagccc       60

accgugcagu gcggcagcga gaccggcccc agccccgagu ggaugcugca gcacgaccug      120

auccccggcg accugagaga ccugagagug gagcccguga ccaccagcgu ggccaccggc      180

gacuacagca uccugaugaa cgugagcugg gugcugagag ccgacgccag caucagacug      240

cugaaggcca ccaagaucug cgugaccggc aagagcaacu uccagagcua cagcugcgug      300

agaugcaacu acaccgaggc cuuccagacc cagaccagac ccagcggcgg caaguggacc      360

uucagcuaca ucggcuuccc cguggagcug aacaccgugu acuucaucgg cgcccacaac      420

auccccaacg ccaacaugaa cgaggacggc cccagcauga gcgugaacuu caccagcccc      480

ggcugccugg accacaucau gaaguacaag aagaagugcg ugaaggccgg cagccugugg      540

gaccccaaca ucaccgccug caagaagaac gaggagaccg uggaggugaa cuucaccacc      600

accccccugg gcaacagaua cauggcccug auccagcaca gcaccaucau cggcuucagc      660

cagguguucg agccccacca gaagaagcag accagagcca gcguggugau ccccgugacc      720

ggcgacagcg agggcgccac cgugcagcug acccccuacu uccccaccug cggcagcgac      780

ugcaucagac acaagggcac cguggugcug ugcccccaga ccggcgugcc cuucccccug      840

gacaacaaca agagcaagcc cggcggcugg cugccccugc ugcugcugag ccugcuggug      900

gccaccuggg ugcugguggc cggcaucuac cugaugugga gacacgagag aaucaagaag      960

accagcuuca gcaccaccac ccugcugccc cccaucaagg ugcugguggu guaccccagc     1020

gagaucugcu uccaccacac caucugcuac uucaccgagu uccugcagaa ccacugcaga     1080

agcgagguga uccuggagaa guggcagaag aagaagaucg ccgagauggg ccccgugcag     1140

uggcuggcca cccagaagaa ggccgccgac aagguggugu uccugcugag caacgacgug     1200

aacagcgugu gcgacggcac cugcggcaag agcgagggca gccccagcga gaacagccag     1260

gaccuguucc cccuggccuu caaccuguuc ugcagcgacc ugagaagcca gauccaccug     1320

cacaaguacg ugguggugua cuucagagag aucgacacca aggacgacua caacgcccug     1380

agcgugugcc ccaaguacca ccugaugaag gacgccaccg ccuucugcgc cgagcugcug     1440

cacgugaagc agcaggugag cgccggcaag agaagccagg ccugccacga cggcugcugc     1500

agccuguga                                                             1509


<210>  4247
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4247
augagccugg ugcuccuguc ccuugccgcu cugugcagau cugccguccc ccgggagccu       60

accguucagu guggcagcga aacagggccg ucccccgagu ggaugcucca acacgaccug      120

aucccuggag aucuucgcga ccugagagug gaacccguga cgaccucugu cgcgacaggc      180

gauuacagca uucucaugaa cguguccugg guucugcggg cugacgccuc uauccgccug      240

cucaaggcca ccaaaauuug cgugacaggc aagagcaauu uccaguccua uagcuguguc      300

agaugcaacu acaccgaggc uuuucagaca cagacccggc cuucuggagg caaauggacg      360

uucuccuaua ucggguuucc cguggaacug aauaccguuu acuucauugg agcccauaac      420

aucccuaaug cuaacaugaa ugaggauggc ccgagcaugu cugugaacuu uacauccccc      480

ggcugucuug accacaucau gaaguauaaa aagaagugcg ucaaagccgg gagccugugg      540

gauccuaaua uuaccgcgug uaagaaaaac gaggaaacag uggaggugaa uuucaccacg      600

acaccccucg gaaaccgcua cauggcccug auccaacauu cuaccauuau cggcuuuucc      660

caggucuucg aaccucacca gaagaaacag acaagagcua gcguugugau ucccgugacc      720

ggggacuccg agggagccac cguccaacuu acaccguauu uuccuacgug cggcucugau      780

uguauccggc auaaggggac cgugguucug ugcccccaga caggagugcc uuucccccuc      840

gacaauaaca agagcaaacc cggcggcugg cugccucugc uccugcuuuc ccugcucguc      900

gcuaccuggg ugcugguugc cgggauuuac cuuauguggc gccacgagag aaucaagaaa      960

acauccuuuu cuaccacgac acugcucccg cccaucaagg ugcuggucgu guacccuucc     1020

gaaauuuguu uccaccauac caucugcuau uuuaccgagu uccugcagaa ucacugccgg     1080

agcgaaguca uucucgagaa auggcagaag aaaaagaucg cggaaauggg acccgugcaa     1140

uggcuggcca cacagaagaa agcugccgau aagguugugu uccuucuguc uaacgacguc     1200

aacagcgugu gugaugggac cugcgggaaa uccgagggau cuccuagcga gaauagccag     1260

gaccucuuuc cccuggcuuu caaccuguuu uguagcgacc uucgcucuca aauucaucuc     1320

cacaaguacg uuguggucua uuucagagaa aucgauacaa aagacgauua caaugcccug     1380

uccgugugcc cgaaguauca ccugaugaag gacgccacgg cuuuuugugc ggagcuccug     1440

caugugaaac agcagguuag cgccggcaag cggucucagg cuugccacga uggguguugc     1500

ucccuuuga                                                             1509


<210>  4248
<211>  1509
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17B__Homo_sapiens__AAH00980

<400>  4248
augucauuag uauuauuauc acuagccgca cuaugucgau cggcuguucc aagagaacca       60

accguacaau gcggaucaga aacaggucca ucaccagaau ggauguuaca acacgacuua      120

auaccgggcg aucuuagaga uuuaagagua gaaccaguua caacaucugu agcuacaggu      180

gauuacucaa uuuuaaugaa cguaagcugg guacuaagag cugacgccuc aauacgccug      240

cuaaaagcaa caaaaauuug cgucaccgga aaauccaacu uucaauccua cucaugugua      300

agaugcaauu auaccgaagc uuuucaaaca caaacacgcc cauccggagg aaaauggaca      360

uuuucauaca uaggauuucc uguagaauua aacacagucu acuuuauagg ugcacauaac      420

auuccaaacg caaacaugaa ugaagaugga ccaucaaugu cagucaacuu cacaucaccu      480

ggaugucuag accauauaau gaaauauaaa aaaaaaugcg uaaaagcugg aucccuaugg      540

gacccaaaca uaacugcaug caaaaaaaau gaagaaacag uagaagucaa uuucacaacu      600

acaccacuug gaaauagaua uauggcucua auacaacacu caacaauaau cggauucucc      660

caaguauuug aaccacacca aaaaaaacaa acacgagccu caguaguaau cccagucaca      720

ggagacuccg aaggagcaac uguacaauua acccccuacu uucccacaug uggcuccgac      780

uguauaagac auaaaggaac aguugucuua ugcccacaaa cagguguacc cuucccccug      840

gacaauaaua aaagcaaacc cgguggaugg cuuccauuac ucuuacuauc acuacuaguc      900

gccacauggg uauuaguagc aggaaucuac uuaauguggc gucaugaacg aauaaaaaaa      960

acaucuuucu ccacuacaac auuacuucca ccaauaaaag uguuaguagu auaccccucc     1020

gaaauaugcu uucaccacac aauaugcuau uuuacagaau uccuacaaaa ccauugcaga     1080

agugaaguaa uacucgaaaa auggcaaaaa aaaaagaucg cagaaauggg accaguccaa     1140

ugguuagcaa cacaaaaaaa agcagcagac aaaguaguau uccuuuuauc aaaugacgua     1200

aacucggucu gugacgguac auguggaaaa ucagaaggau caccaucaga aaacucacaa     1260

gaccuauucc cacuagcauu caauuuauuu ugcucagacu uaagaucaca aauacacuua     1320

cacaaauaug uaguagucua cuuuagagaa auagacacaa aagacgauua uaacgcauua     1380

agugucuguc caaaauacca cuuaaugaaa gacgcaacag cauuuugugc ugaauuacua     1440

cacguuaaac agcaaguauc ugccgguaaa agaucacaag caugucacga cggaugcugu     1500

ucccuauaa                                                             1509


<210>  4249
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17B__Homo_sapiens__Q9UHF5

<400>  4249

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  4250
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17B__Homo_sapiens__AAF01318

<400>  4250
auggacuggc cucacaaccu gcuguuucuu cuuaccauuu ccaucuuccu ggggcugggc       60

cagcccagga gccccaaaag caagaggaag gggcaagggc ggccugggcc ccuggccccu      120

ggcccucacc aggugccacu ggaccuggug ucacggauga aaccguaugc ccgcauggag      180

gaguaugaga ggaacaucga ggagauggug gcccagcuga ggaacagcuc agagcuggcc      240

cagagaaagu gugaggucaa cuugcagcug uggaugucca acaagaggag ccugucuccc      300

uggggcuaca gcaucaacca cgaccccagc cguauccccg uggaccugcc ggaggcacgg      360

ugccuguguc ugggcugugu gaaccccuuc accaugcagg aggaccgcag cauggugagc      420

gugccggugu ucagccaggu uccugugcgc cgccgccucu gcccgccacc gccccgcaca      480

gggccuugcc gccagcgcgc agucauggag accaucgcug ugggcugcac cugcaucuuc      540

uga                                                                    543


<210>  4251
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4251
auggacuggc cccacaaccu ccuguuccug cugaccauca gcaucuuccu cggccugggg       60

cagccccgcu cccccaagag caagcggaag ggccaggggc gccccggccc ccuggccccg      120

gggccccacc aggugccccu cgaccugguc ucccggauga agcccuacgc ccgcauggag      180

gaguacgagc ggaacaucga ggagauggug gcgcagcugc gcaacagcuc cgagcucgcc      240

cagcggaagu gcgaggugaa ccugcagcug uggaugagca acaagcgcuc ccucagcccg      300

uggggcuacu ccaucaacca cgaccccagc cggauccccg ucgaccugcc cgaggcccgc      360

ugccugugcc ucggcugcgu gaacccguuc accaugcagg aggaccgguc cauggugagc      420

guccccgugu ucucccaggu gcccguccgc cggcgccugu gcccgccccc gccccggacc      480

gggcccugcc gccagcgggc cgugauggag accaucgccg ugggcugcac gugcaucuuc      540

uga                                                                    543


<210>  4252
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4252
auggacuggc cccacaaccu ccucuuccuc cucaccaucu ccaucuuccu cggccucggc       60

cagccccgcu cccccaaguc caagcgcaag ggccagggcc gccccggccc ccucgccccc      120

ggcccccacc aggucccccu cgaccucguc ucccgcauga agcccuacgc ccgcauggag      180

gaguacgagc gcaacaucga ggagaugguc gcccagcucc gcaacuccuc cgagcucgcc      240

cagcgcaagu gcgaggucaa ccuccagcuc uggaugucca acaagcgcuc ccucuccccc      300

uggggcuacu ccaucaacca cgaccccucc cgcauccccg ucgaccuccc cgaggcccgc      360

ugccucugcc ucggcugcgu caaccccuuc accaugcagg aggaccgcuc cauggucucc      420

guccccgucu ucucccaggu ccccguccgc cgccgccucu gccccccccc cccccgcacc      480

ggccccugcc gccagcgcgc cgucauggag accaucgccg ucggcugcac cugcaucuuc      540

uga                                                                    543


<210>  4253
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4253
auggacuggc cccacaaccu guuguuccuu cugaccauca gcauuuuucu cggcuuaggg       60

cagccuagau ccccaaaguc uaaaaggaag ggacaagguc ggccgggccc ccuggccccu      120

gggccacauc aggugccccu agaucucguc ucacgcauga aaccuuacgc ucgaauggag      180

gaauaugagc guaauauaga agagaugguu gcacagcuga gaaacaguag cgaacuugcc      240

cagaggaagu gcgaggugaa ucugcaauug uggaugucca acaaacgguc ucucucgcca      300

uggggauacu caaucaauca cgaccccagc cgcauuccug uagaucugcc agaggcgaga      360

ugucugugcc ucggcugugu gaacccguuc acaaugcagg aagacaggag uauggucucc      420

gugcccgugu uuucucaggu uccuguccgg cgccgauuau gcccaccccc uccaagaacu      480

ggucccugua ggcagcgggc ugugauggag acgaucgccg uagggugcac cuguauuuuc      540

uga                                                                    543


<210>  4254
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4254
auggacuggc cccacaaccu gcuguuccug cugaccauca gcaucuuccu gggccugggc       60

cagcccagaa gccccaagag caagagaaag ggccagggca gacccggccc ccuggccccc      120

ggcccccacc aggugccccu ggaccuggug agcagaauga agcccuacgc cagaauggag      180

gaguacgaga gaaacaucga ggagauggug gcccagcuga gaaacagcag cgagcuggcc      240

cagagaaagu gcgaggugaa ccugcagcug uggaugagca acaagagaag ccugagcccc      300

uggggcuaca gcaucaacca cgaccccagc agaauccccg uggaccugcc cgaggccaga      360

ugccugugcc ugggcugcgu gaaccccuuc accaugcagg aggacagaag cauggugagc      420

gugcccgugu ucagccaggu gcccgugaga agaagacugu gccccccccc ccccagaacc      480

ggccccugca gacagagagc cgugauggag accaucgccg ugggcugcac cugcaucuuc      540

uga                                                                    543


<210>  4255
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4255
auggacuggc cccacaaccu ccuguuccug cuuaccauca gcauuuuucu gggccucggg       60

cagccuagau ccccgaaguc uaaacggaag ggacaaggcc gccccgggcc ucuggccccc      120

ggaccucauc aggugccccu ugaucugguc agcagaauga aaccuuacgc ucggauggag      180

gaauaugagc gcaauaucga agagaugguu gcccagcuca gaaacuccuc ugaacuggcg      240

cagcggaagu gcgaggugaa ucugcaacuc uggaugagca acaaacgcuc ccugucuccg      300

uggggcuaca gcauuaauca cgaccccucc agaaucccug uggaucuucc cgaggcucgg      360

ugucugugcc ucgggugugu caacccuuuc acaaugcagg aagaccgcag cauggugucu      420

guucccgugu uuucccaggu cccggugaga cggcgccugu gcccuccccc ucccagaacg      480

ggacccuguc ggcagcgcgc cguuauggag accauugccg ugggcugcac auguaucuuc      540

uga                                                                    543


<210>  4256
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17B__Homo_sapiens__AAF01318

<400>  4256
auggacuggc cacauaacuu acuauuuuua uuaacaauaa guauauucuu aggauuagga       60

caaccaagaa gcccaaaauc aaaaagaaaa ggacaaggaa gaccaggacc acuagcacca      120

ggaccacauc aaguaccauu agacuuaguc ucaagaauga aaccauacgc aagaauggaa      180

gaauacgaaa gaaauauaga agaaauggua gcacaauuaa gaaauagcuc agaauuagca      240

caaagaaaau gcgaaguaaa ucuacaacua uggaugucaa acaaaagauc gcuaucacca      300

uggggauaua gcauaaacca ugacccauca agaauaccag uagacuuacc agaagcaaga      360

ugucuauguc uaggaugcgu aaacccauuc acaaugcaag aagauagauc aaugguaagc      420

guaccaguau ucucacaagu accaguaaga agaagauuau gcccaccacc accaagaaca      480

ggaccaugca gacaaagagc agucauggaa acaauagcag uaggaugcac augcauauuu      540

uaa                                                                    543


<210>  4257
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17D__Homo_sapiens__Q8TAD2

<400>  4257

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  4258
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17D__Homo_sapiens__AAH36243

<400>  4258
augcugguag ccggcuuccu gcuggcgcug ccgccgagcu gggccgcggg cgccccgagg       60

gcgggcaggc gccccgcgcg gccgcggggc ugcgcggacc ggccggagga gcuacuggag      120

cagcuguacg ggcgccuggc ggccggcgug cucagugccu uccaccacac gcugcagcug      180

gggccgcgug agcaggcgcg caacgcgagc ugcccggcag ggggcaggcc cgccgaccgc      240

cgcuuccggc cgcccaccaa ccugcgcagc gugucgcccu gggccuacag aaucuccuac      300

gacccggcga gguaccccag guaccugccu gaagccuacu gccugugccg gggcugccug      360

accgggcugu ucggcgagga ggacgugcgc uuccgcagcg ccccugucua caugcccacc      420

gucguccugc gccgcacccc cgccugcgcc ggcggccguu ccgucuacac cgaggccuac      480

gucaccaucc ccgugggcug caccugcguc cccgagccgg agaaggacgc agacagcauc      540

aacuccagca ucgacaaaca gggcgccaag cuccugcugg gccccaacga cgcgcccgcu      600

ggccccuga                                                              609


<210>  4259
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4259
augcuggugg ccggcuuccu ccuggcccug cccccgagcu gggcggccgg ggcgccccgc       60

gccggccggc gccccgcccg gccccgcggg ugcgccgacc ggccggagga gcuccuggag      120

cagcuguacg gccgccucgc cgccgggguc cuguccgccu uccaccacac ccugcagcuc      180

ggcccccggg agcaggcgcg caacgccagc ugccccgccg gcgggcggcc cgccgaccgc      240

cgguuccgcc cgcccaccaa ccugcggucc gugagccccu gggccuaccg caucuccuac      300

gaccccgcgc gguacccgcg cuaccugccc gaggccuacu gccucugccg gggcugccug      360

accgggcugu ucggcgagga ggacgugcgc uuccggagcg cccccgucua caugcccacc      420

guggugcucc gccggacccc ggccugcgcc gggggccgcu ccgucuacac cgaggcguac      480

gugacgaucc ccgugggcug cacgugcguc cccgagcccg agaaggacgc cgacagcauc      540

aacuccagca ucgacaagca gggggccaag cugcugcucg gcccgaacga cgcccccgcc      600

gggcccuga                                                              609


<210>  4260
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4260
augcucgucg ccggcuuccu ccucgcccuc ccccccuccu gggccgccgg cgccccccgc       60

gccggccgcc gccccgcccg cccccgcggc ugcgccgacc gccccgagga gcuccucgag      120

cagcucuacg gccgccucgc cgccggcguc cucuccgccu uccaccacac ccuccagcuc      180

ggcccccgcg agcaggcccg caacgccucc ugccccgccg gcggccgccc cgccgaccgc      240

cgcuuccgcc cccccaccaa ccuccgcucc gucucccccu gggccuaccg caucuccuac      300

gaccccgccc gcuacccccg cuaccucccc gaggccuacu gccucugccg cggcugccuc      360

accggccucu ucggcgagga ggacguccgc uuccgcuccg cccccgucua caugcccacc      420

gucguccucc gccgcacccc cgccugcgcc ggcggccgcu ccgucuacac cgaggccuac      480

gucaccaucc ccgucggcug caccugcguc cccgagcccg agaaggacgc cgacuccauc      540

aacuccucca ucgacaagca gggcgccaag cuccuccucg gccccaacga cgcccccgcc      600

ggccccuga                                                              609


<210>  4261
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4261
augcuggugg ccggcuuccu ccuugcucug cccccuagcu gggcagccgg ggcgccaaga       60

gcuggaaggc ggccggcccg cccccgaggu ugcgcagacc guccugagga auuguuagag      120

cagcuguacg gcagacuagc cgcugggguc cucuccgcau uucaccauac ccugcaacuu      180

ggaccaaggg aacaggcccg gaacgcuucu ugucccgccg gcggucgccc ugcggauaga      240

agguuccggc cacccacaaa ucugcgcuca guuaguccuu gggcauaucg aaucagcuac      300

gacccagcca gauauccgag guacuugccc gaggcuuauu gccucugucg ggggugccug      360

acuggacugu uuggcgaaga ggaugugcgu uuccgcuccg ccccuguaua caugccaacg      420

gugguccuca gaaggacccc cgcaugugcu ggcgggcggu cuguguauac agaggccuac      480

guuacuauuc cugugggaug caccuguguc ccagaacccg agaaggacgc ggauucgaua      540

aacucaagca ucgacaaaca gggugccaag uuacugcuug gcccgaauga ugcuccugca      600

gggcccuga                                                              609


<210>  4262
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4262
augcuggugg ccggcuuccu gcuggcccug ccccccagcu gggccgccgg cgcccccaga       60

gccggcagaa gacccgccag acccagaggc ugcgccgaca gacccgagga gcugcuggag      120

cagcuguacg gcagacuggc cgccggcgug cugagcgccu uccaccacac ccugcagcug      180

ggccccagag agcaggccag aaacgccagc ugccccgccg gcggcagacc cgccgacaga      240

agauucagac cccccaccaa ccugagaagc gugagccccu gggccuacag aaucagcuac      300

gaccccgcca gauaccccag auaccugccc gaggccuacu gccugugcag aggcugccug      360

accggccugu ucggcgagga ggacgugaga uucagaagcg cccccgugua caugcccacc      420

guggugcuga gaagaacccc cgccugcgcc ggcggcagaa gcguguacac cgaggccuac      480

gugaccaucc ccgugggcug caccugcgug cccgagcccg agaaggacgc cgacagcauc      540

aacagcagca ucgacaagca gggcgccaag cugcugcugg gccccaacga cgcccccgcc      600

ggccccuga                                                              609


<210>  4263
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4263
augcuggugg ccggcuuccu ccuggcccuu cccccuagcu gggcugcggg ggcuccgaga       60

gccggacggc gccccgccag accucggggc ugcgcugacc gccccgagga acugcucgag      120

cagcuguacg ggagacuugc cgcuggaguc cuguccgccu uucaccauac ccuccaacug      180

ggcccucggg aacaggcgcg caacgccucu ugucccgcug ggggaagacc ugccgaucgg      240

cgcuucagac cgcccacaaa ucugcggagc guuuccccuu gggcuuaucg caucucuuac      300

gaccccgcca gauauccucg guaccucccc gaggcguauu gccugugucg cggcugccuu      360

acgggccugu uuggggaaga ggaugugaga uuccggagcg ccccggugua caugccuacc      420

gucgugcuca gacgcacacc cgcuugugcc ggaggccggu ccguuuauac cgaggcuuac      480

gugacaauuc cugucgggug caccugugug cccgaacccg agaaggacgc cgauucuauc      540

aacagcucca uugacaaaca gggagccaag cugcuucugg gcccuaauga ugcuccggcg      600

gggcccuga                                                              609


<210>  4264
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17D__Homo_sapiens__AAH36243

<400>  4264
augcuaguag caggcuuuuu acuagcauua ccaccaaguu gggcagcagg agcaccaaga       60

gcaggaagaa gaccagcaag accacgagga ugcgcagaua gaccagaaga auuauuagaa      120

caauuauaug gaagauuagc agcaggagua uuaucagcau uucaucauac auuacaauua      180

ggaccaagag aacaagcaag aaaugcauca uguccagcag gaggaagacc agcagacaga      240

agauuuagac caccaacaaa ucuaagaagu guaucaccau gggcauauag aauaucauac      300

gauccagcaa gauauccuag auacuuacca gaagcauacu guuuauguag aggauguuua      360

acuggacuau uuggagaaga agauguaaga uuuagaucag caccaguaua uaugccaaca      420

guaguauuaa gaagaacacc agcaugugca ggagguagau caguauauac agaagcauau      480

guuacaauac caguaggaug cacaugugua ccagaaccag aaaaagaugc agauaguaua      540

aauucaucaa uagacaaaca aggagcaaaa uuauuauuag gaccuaacga ugcaccagca      600

ggaccauaa                                                              609


<210>  4265
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17F__Homo_sapiens__F1JZ09

<400>  4265

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Leu Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  4266
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17F__Homo_sapiens__ADY18335

<400>  4266
augacaguga agacccugca uggcccagcc auggucaagu acuugcugcu gucgauauug       60

gggcuugccu uucugaguga ggcggcagcu cggaaaaucc ccaaaguagg acauacuuuu      120

uuccaaaagc cugagaguug cccgccugug ccaggaggua guaugaagcu ugacauuggc      180

aucaucaaug aaaaccagcg cguuuccaug ucacguaaca ucgagagccg cuccaccucc      240

cccuggaauu acacugucac uugggacccc aaccgguacc ccuuggaagu uguacaggcc      300

caguguagga acuugggcug caucaaugcu caaggaaagg aagacaucuc caugaauucc      360

guucccaucc agcaagagac ccuggucguc cggaggaagc accaaggcug cucuguuucu      420

uuccaguugg agaaggugcu ggugacuguu ggcugcaccu gcgucacccc ugucauccac      480

caugugcagu aa                                                          492


<210>  4267
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4267
augaccguga agacccugca cggccccgcc auggucaagu accuccugcu gagcauccuc       60

gggcuggccu uccuguccga ggcggccgcc cgcaagaucc cgaagguggg ccacaccuuc      120

uuccagaagc ccgagagcug cccgcccgug cccgggggcu ccaugaagcu cgacaucggg      180

aucaucaacg agaaccagcg ggucagcaug ucccgcaaca ucgagagccg guccaccagc      240

cccuggaacu acaccgugac cugggacccc aaccgcuacc cccuggaggu gguccaggcc      300

cagugccgga accugggcug caucaacgcc cagggcaagg aggacaucuc caugaacagc      360

gugccgaucc agcaggagac gcucgugguc cgccggaagc accaggggug cuccgugagc      420

uuccagcugg agaaggugcu ggucaccgug ggcugcacgu gcgugacccc cgucauccac      480

cacgugcagu ga                                                          492


<210>  4268
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4268
augaccguca agacccucca cggccccgcc auggucaagu accuccuccu cuccauccuc       60

ggccucgccu uccucuccga ggccgccgcc cgcaagaucc ccaaggucgg ccacaccuuc      120

uuccagaagc ccgaguccug cccccccguc cccggcggcu ccaugaagcu cgacaucggc      180

aucaucaacg agaaccagcg cgucuccaug ucccgcaaca ucgagucccg cuccaccucc      240

cccuggaacu acaccgucac cugggacccc aaccgcuacc cccucgaggu cguccaggcc      300

cagugccgca accucggcug caucaacgcc cagggcaagg aggacaucuc caugaacucc      360

guccccaucc agcaggagac ccucgucguc cgccgcaagc accagggcug cuccgucucc      420

uuccagcucg agaagguccu cgucaccguc ggcugcaccu gcgucacccc cgucauccac      480

cacguccagu ga                                                          492


<210>  4269
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4269
augaccguga agacacugca cggccccgcc auggucaaau accuccuucu gagcaucuug       60

ggguuagcuu uccuguccga ggcagccgcg agaaagauuc cuaaaguugg acauacguuu      120

uuccagaagc cagaaucuug cccgcccgug ccugguggcu caaugaaacu agacauaggg      180

aucauuaacg agaaucaaag gguaaguaug agccggaaca ucgaaucccg cucuacuucg      240

ccauggaauu auaccgugac augggauccc aaccgauacc cucucgaggu cgugcaggcu      300

cagugucgua aucugggaug cauuaacgcc cagggcaagg aagacaucuc aaugaauagc      360

guuccaauac aacaggagac ucuugugguc agaaggaagc accaggguug uagugugucc      420

uuucagcugg agaaaguauu gguuaccgug gggugcacau gugucacccc cgugauccau      480

cacgugcaau ga                                                          492


<210>  4270
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4270
augaccguga agacccugca cggccccgcc auggugaagu accugcugcu gagcauccug       60

ggccuggccu uccugagcga ggccgccgcc agaaagaucc ccaagguggg ccacaccuuc      120

uuccagaagc ccgagagcug cccccccgug cccggcggca gcaugaagcu ggacaucggc      180

aucaucaacg agaaccagag agugagcaug agcagaaaca ucgagagcag aagcaccagc      240

cccuggaacu acaccgugac cugggacccc aacagauacc cccuggaggu ggugcaggcc      300

cagugcagaa accugggcug caucaacgcc cagggcaagg aggacaucag caugaacagc      360

gugcccaucc agcaggagac ccugguggug agaagaaagc accagggcug cagcgugagc      420

uuccagcugg agaaggugcu ggugaccgug ggcugcaccu gcgugacccc cgugauccac      480

cacgugcagu ga                                                          492


<210>  4271
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4271
augaccguga agacacugca cggccccgcc auggucaaau accuccugcu uagcauccug       60

gggcucgcuu uccuguccga ggccgcggcu agaaagauuc cuaaaguugg acauacguuu      120

uuccagaagc cggaaucuug ucccccugug cccggcggga gcaugaaacu ugacaucgga      180

auuaucaaug agaaucaacg gguguccaug ucucgcaaca uugaaagcag auccaccucu      240

ccuuggaauu auacagucac cugggauccc aaccgguacc cucuggaggu gguucaggcc      300

cagugccgca aucucggcug caucaacgcc caggggaagg aagacaucag caugaacucc      360

gugccgauuc aacaggagac acuggucgug agacggaagc accagggaug uagcguuucu      420

uuucagcugg agaaagugcu cgucaccgug ggcugcacau gugugacccc cgucauccau      480

cacguucaau ga                                                          492


<210>  4272
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17F__Homo_sapiens__ADY18335

<400>  4272
augacaguaa aaacccuaca cggaccagca augguaaaau accuacuacu aucaauacua       60

ggauuagcau uucuaucaga agcagcagca agaaaaauac caaaaguagg acacacauuu      120

uuccaaaaac cagaaucaug cccacccgua ccaggaggau caaugaaacu agacauagga      180

auaauaaacg aaaaccaaag aguaucaaug ucaagaaaca uagaaucacg aucaacauca      240

ccauggaacu acacaguaac augggaccca aacagauacc cacuagaagu aguacaagca      300

caaugcagaa accuaggaug cauaaacgca caaggaaaag aagacauauc aaugaacuca      360

guuccaauac aacaagaaac auuaguagua agaagaaaac accaaggaug cucaguauca      420

uuccaacuag aaaaaguacu aguaacagua ggaugcacau gcguaacacc agucauacac      480

cacguacaau aa                                                          492


<210>  4273
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-17F__Homo_sapiens__Q96PD4

<400>  4273

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  4274
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-17F__Homo_sapiens__AAK83350

<400>  4274
augacaguga agacccugca uggcccagcc auggucaagu acuugcugcu gucgauauug       60

gggcuugccu uucugaguga ggcggcagcu cggaaaaucc ccaaaguagg acauacuuuu      120

uuccaaaagc cugagaguug cccgccugug ccaggaggua guaugaagcu ugacauuggc      180

aucaucaaug aaaaccagcg cguuuccaug ucacguaaca ucgagagccg cuccaccucc      240

cccuggaauu acacugucac uugggacccc aaccgguacc ccucggaagu uguacaggcc      300

caguguagga acuugggcug caucaaugcu caaggaaagg aagacaucuc caugaauucc      360

guucccaucc agcaagagac ccuggucguc cggaggaagc accaaggcug cucuguuucu      420

uuccaguugg agaaggugcu ggugacuguu ggcugcaccu gcgucacccc ugucauccac      480

caugugcagu aa                                                          492


<210>  4275
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4275
augaccguga agacccugca cggccccgcc auggucaagu accuccugcu gagcauccuc       60

gggcuggccu uccuguccga ggcggccgcc cgcaagaucc cgaagguggg ccacaccuuc      120

uuccagaagc ccgagagcug cccgcccgug cccgggggcu ccaugaagcu cgacaucggg      180

aucaucaacg agaaccagcg ggucagcaug ucccgcaaca ucgagagccg guccaccagc      240

cccuggaacu acaccgugac cugggacccc aaccgcuacc ccuccgaggu gguccaggcc      300

cagugccgga accugggcug caucaacgcc cagggcaagg aggacaucag caugaacucc      360

gugccgaucc agcaggagac gcuggugguc cgccggaagc accaggggug cagcgugucc      420

uuccagcucg agaaggugcu ggucaccgug ggcugcacgu gcgugacccc cgucauccac      480

cacgugcagu ga                                                          492


<210>  4276
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4276
augaccguca agacccucca cggccccgcc auggucaagu accuccuccu cuccauccuc       60

ggccucgccu uccucuccga ggccgccgcc cgcaagaucc ccaaggucgg ccacaccuuc      120

uuccagaagc ccgaguccug cccccccguc cccggcggcu ccaugaagcu cgacaucggc      180

aucaucaacg agaaccagcg cgucuccaug ucccgcaaca ucgagucccg cuccaccucc      240

cccuggaacu acaccgucac cugggacccc aaccgcuacc ccuccgaggu cguccaggcc      300

cagugccgca accucggcug caucaacgcc cagggcaagg aggacaucuc caugaacucc      360

guccccaucc agcaggagac ccucgucguc cgccgcaagc accagggcug cuccgucucc      420

uuccagcucg agaagguccu cgucaccguc ggcugcaccu gcgucacccc cgucauccac      480

cacguccagu ga                                                          492


<210>  4277
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4277
augaccguga agacacugca cggccccgcc auggucaaau accuccuucu gagcaucuug       60

ggguuagcuu uccuguccga ggcagccgcg agaaagauuc cuaaaguugg acauacguuu      120

uuccagaagc cagaaucuug cccgcccgug ccugguggcu caaugaaacu agacauaggg      180

aucauuaacg agaaucaaag gguaaguaug agccggaaca ucgaaucccg cucuacuucg      240

ccauggaauu auaccgugac augggauccc aaccgauacc cuucagaggu cgugcaggcu      300

cagugucgua aucucggaug cauuaacgcc cagggcaagg aagacaucag caugaauagu      360

guuccaauac aacaggagac ucuggugguc agaaggaagc accaggguug uuccgugucu      420

uuucagcuug agaaaguacu gguuaccgug gggugcacau gugucacccc cgugauccau      480

cacgugcaau ga                                                          492


<210>  4278
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4278
augaccguga agacccugca cggccccgcc auggugaagu accugcugcu gagcauccug       60

ggccuggccu uccugagcga ggccgccgcc agaaagaucc ccaagguggg ccacaccuuc      120

uuccagaagc ccgagagcug cccccccgug cccggcggca gcaugaagcu ggacaucggc      180

aucaucaacg agaaccagag agugagcaug agcagaaaca ucgagagcag aagcaccagc      240

cccuggaacu acaccgugac cugggacccc aacagauacc ccagcgaggu ggugcaggcc      300

cagugcagaa accugggcug caucaacgcc cagggcaagg aggacaucag caugaacagc      360

gugcccaucc agcaggagac ccugguggug agaagaaagc accagggcug cagcgugagc      420

uuccagcugg agaaggugcu ggugaccgug ggcugcaccu gcgugacccc cgugauccac      480

cacgugcagu ga                                                          492


<210>  4279
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4279
augaccguga agacacugca cggccccgcc auggucaaau accuccugcu uagcauccug       60

gggcucgcuu uccuguccga ggccgcggcu agaaagauuc cuaaaguugg acauacguuu      120

uuccagaagc cggaaucuug ucccccugug cccggcggga gcaugaaacu ugacaucgga      180

auuaucaacg agaaucaacg gguguccaug ucucgcaaca uugaaagcag auccaccucu      240

ccuuggaauu auacagucac cugggauccc aaccgguacc cuagcgaggu gguucaggcc      300

cagugccgca aucugggcug caucaacgcc caggggaagg aagacaucuc caugaauagc      360

gugccgauuc aacaggagac acucgucgug agacggaagc accagggaug uucuguuucc      420

uuucagcugg agaaagugcu ggucaccgug ggcugcacau gugugacccc cgucauccau      480

cacguucaau ga                                                          492


<210>  4280
<211>  492
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-17F__Homo_sapiens__AAK83350

<400>  4280
augacaguaa aaacacuaca cggaccagca auggucaaau accuacuacu aucaauacua       60

ggacuagcau uccuaucaga agcagcagca agaaaaauac caaaaguagg acacacauuc      120

uuccaaaaac cagaauccug cccaccagua ccaggaggau caaugaaacu agacauagga      180

auaauaaacg aaaaccaaag aguaagcaug ucaagaaaca uagaauccag aucaacaucc      240

ccauggaacu acacaguaac cugggaccca aacagauacc caucagaagu aguacaagca      300

caaugcagaa accuaggcug cauaaacgca caaggaaaag aagacauauc aaugaacuca      360

guaccaauac aacaagaaac auuaguagua agaagaaaac accaaggaug cucaguauca      420

uuccaacuag aaaaaguacu aguaacagua ggaugcacau gcguaacucc aguaauacac      480

cacguacaau aa                                                          492


<210>  4281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__A0A024R3E0

<400>  4281

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Glu Asn Leu Glu Ser Asp 
            20                  25                  30          


Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
        35                  40                  45              


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
    50                  55                  60                  


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
65                  70                  75                  80  


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
                85                  90                  95      


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
            100                 105                 110         


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
        115                 120                 125             


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
    130                 135                 140                 


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
145                 150                 155                 160 


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
                165                 170                 175     


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
            180                 185                 


<210>  4282
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__EAW67185

<400>  4282
auggcugcug aaccaguaga agacaauugc aucaacuuug uggcaaugaa auuuauugac       60

aauacgcuuu acuuuauaga aaaccuggaa uccgauuacu uuggcaagcu ugaaucuaaa      120

uuaucaguca uaagaaauuu gaaugaccaa guucucuuca uugaccaagg aaaucggccu      180

cuauuugaag auaugacuga uucugacugu agagauaaug caccccggac cauauuuauu      240

auaaguaugu auaaagauag ccagccuaga gguauggcug uaacuaucuc ugugaagugu      300

gagaaaauuu caacucucuc cugugagaac aaaauuauuu ccuuuaagga aaugaauccu      360

ccugauaaca ucaaggauac aaaaagugac aucauauucu uucagagaag ugucccagga      420

caugauaaua agaugcaauu ugaaucuuca ucauacgaag gauacuuucu agcuugugaa      480

aaagagagag accuuuuuaa acucauuuug aaaaaagagg augaauuggg ggauagaucu      540

auaauguuca cuguucaaaa cgaagacuag                                       570


<210>  4283
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-18__Homo_sapiens__EAW67185

<400>  4283
auggccgccg agcccgugga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccugu acuucaucga gaaccucgag agcgacuacu ucggcaagcu ggaguccaag      120

cugagcguga uccgcaaccu caacgaccag gugcuguuca ucgaccaggg gaaccggccg      180

cuguucgagg acaugaccga cuccgacugc cgcgacaacg cgccccggac gaucuucauc      240

aucagcaugu acaaggacuc ccagccccgc ggcauggccg ucaccaucag cgugaagugc      300

gagaagaucu ccacccucag cugcgagaac aagaucaucu ccuucaagga gaugaacccg      360

cccgacaaca ucaaggacac caagagcgac aucaucuucu uccagcgguc cgugcccggg      420

cacgacaaca agaugcaguu cgagagcucc agcuacgagg gcuacuuccu ggccugcgag      480

aaggagcgcg accuguucaa gcucauccug aagaaggagg acgagcuggg ggaccggucc      540

aucauguuca cgguccagaa cgaggacuga                                       570


<210>  4284
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-18__Homo_sapiens__EAW67185

<400>  4284
auggccgccg agcccgucga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccucu acuucaucga gaaccucgag uccgacuacu ucggcaagcu cgaguccaag      120

cucuccguca uccgcaaccu caacgaccag guccucuuca ucgaccaggg caaccgcccc      180

cucuucgagg acaugaccga cuccgacugc cgcgacaacg ccccccgcac caucuucauc      240

aucuccaugu acaaggacuc ccagccccgc ggcauggccg ucaccaucuc cgucaagugc      300

gagaagaucu ccacccucuc cugcgagaac aagaucaucu ccuucaagga gaugaacccc      360

cccgacaaca ucaaggacac caaguccgac aucaucuucu uccagcgcuc cguccccggc      420

cacgacaaca agaugcaguu cgaguccucc uccuacgagg gcuacuuccu cgccugcgag      480

aaggagcgcg accucuucaa gcucauccuc aagaaggagg acgagcucgg cgaccgcucc      540

aucauguuca ccguccagaa cgaggacuga                                       570


<210>  4285
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-18__Homo_sapiens__EAW67185

<400>  4285
auggccgcug agcccgugga agacaacugc aucaauuucg ucgcaaugaa guuuauugau       60

aacacccugu acuucauaga gaaucucgaa agcgacuauu uuggcaaacu ugaguccaag      120

cugucuguua ucagaaacuu gaaugaucag guguuauuca uugaccaagg gaacaggccu      180

cuguuugaag auaugacaga cucagauugu cgggacaaug ccccacgcac uaucuucauu      240

aucaguaugu acaaagauag ccagccgcga ggaauggcgg uaacgauauc cgugaagugc      300

gagaaaaucu cuacccuauc gugugagaac aagauuaucu cauuuaagga aaugaauccc      360

ccugacaaca uuaaagauac aaagagcgac aucauauucu uucagcguag ugucccaggu      420

cacgauaaua aaaugcaguu cgaguccucu agcuaugaag gcuacuuucu cgcuugcgag      480

aaggagagag accuguucaa acuuauucug aagaaggaag acgaguuggg ggauaggucc      540

aucauguuua cugugcaaaa cgaagacuga                                       570


<210>  4286
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-18__Homo_sapiens__EAW67185

<400>  4286
auggccgccg agcccgugga ggacaacugc aucaacuucg uggccaugaa guucaucgac       60

aacacccugu acuucaucga gaaccuggag agcgacuacu ucggcaagcu ggagagcaag      120

cugagcguga ucagaaaccu gaacgaccag gugcuguuca ucgaccaggg caacagaccc      180

cuguucgagg acaugaccga cagcgacugc agagacaacg cccccagaac caucuucauc      240

aucagcaugu acaaggacag ccagcccaga ggcauggccg ugaccaucag cgugaagugc      300

gagaagauca gcacccugag cugcgagaac aagaucauca gcuucaagga gaugaacccc      360

cccgacaaca ucaaggacac caagagcgac aucaucuucu uccagagaag cgugcccggc      420

cacgacaaca agaugcaguu cgagagcagc agcuacgagg gcuacuuccu ggccugcgag      480

aaggagagag accuguucaa gcugauccug aagaaggagg acgagcuggg cgacagaagc      540

aucauguuca ccgugcagaa cgaggacuga                                       570


<210>  4287
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-18__Homo_sapiens__EAW67185

<400>  4287
auggccgcug agcccgugga agacaacugc aucaauuucg ucgccaugaa guuuauugau       60

aacacccugu acuucaucga gaaucucgaa agcgacuauu uuggcaaacu ggaguccaag      120

cucucuguua uuagaaaccu gaaugaucag gugcuuuuca ucgaccaagg gaaccggccu      180

cuguuugaag auaugacaga cagcgauugu cgcgacaaug cgccgagaac gauuuucauc      240

aucuccaugu acaaagauuc ucagccccgg ggaauggcug ugaccauuag cgucaagugc      300

gagaaaaucu ccacacuuuc uugugagaac aagauuauca gcuuuaagga aaugaauccu      360

cccgacaaca uuaaagauac caaguccgac aucauuuucu uucagcgcag cgugccuggc      420

cacgauaaua aaaugcaguu cgagucuucc agcuaugaag gguacuuucu ggccugcgag      480

aaggagagag accucuucaa acugauccug aagaaggaag acgagcucgg agaucggucu      540

aucauguuua caguucaaaa cgaagacuga                                       570


<210>  4288
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-18__Homo_sapiens__EAW67185

<400>  4288
auggcagcag aaccaguaga agacaacugc auaaacuucg uagcaaugaa auucauagac       60

aacacauuau acuucauaga aaaccuagaa ucagacuacu ucggaaaacu agaaucaaaa      120

cuaucaguaa uacgcaacuu aaacgaccaa guacuauuca uagaccaagg aaacagaccc      180

cuauucgaag acaugacaga cucagacugc agagacaacg caccaagaac aauauucaua      240

auaucaaugu acaaagacag ccaaccaaga ggaauggcag uaacaauauc aguaaaaugu      300

gaaaaaauau caacacuaag cugcgaaaac aaaauaauaa gcuucaaaga aaugaaccca      360

ccagacaaca uaaaagacac aaaauccgac auaauauucu uccaaagauc aguacccgga      420

cacgacaaca aaaugcaauu cgaaucauca ucauacgaag gauacuuccu agcaugcgaa      480

aaagaacgag accuauucaa acuaauacua aaaaaagaag augaacuagg agacagauca      540

auaauguuca caguacaaaa cgaagacuaa                                       570


<210>  4289
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__B0YJ28

<400>  4289

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Gly Glu Leu Leu Lys Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  4290
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__ACA06006

<400>  4290
auggcugcug aaccaguaga agacaauugc aucaacuuug uggcaaugaa auuuauugac       60

aauacgcuuu acuuuauagg ugaacuauua aaaaaccugg aaucagauua cuuuggcaag      120

cuugaaucua aauuaucagu cauaagaaau uugaaugacc aaguucucuu cauugaccaa      180

ggaaaucggc cucuauuuga agauaugacu gauucugacu guagagauaa ugcaccccgg      240

accauauuua uuauaaguau guauaaagau agccagccua gagguauggc uguaacuauc      300

ucugugaagu gugagaaaau uucaacucuc uccugugaga acaaaauuau uuccuuuaag      360

gaaaugaauc cuccugauaa caucaaggau acaaaaagug acaucauauu cuuucagaga      420

agugucccag gacaugauaa uaagaugcaa uuugaaucuu caucauacga aggauacuuu      480

cuagcuugug aaaaagagag agaccuuuuu aaacucauuu ugaaaaaaga ggaugaauug      540

ggggauagau cuauaauguu cacuguucaa aacgaagacu ag                         582


<210>  4291
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-18__Homo_sapiens__ACA06006

<400>  4291
auggccgccg agcccgugga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccugu acuucaucgg cgagcuccug aagaaccugg agagcgacua cuucgggaag      120

cucgagucca agcugagcgu gauccgcaac cugaacgacc agguccucuu caucgaccag      180

ggcaaccggc cgcuguucga ggacaugacc gacuccgacu gccgcgacaa cgcgccccgg      240

acgaucuuca ucaucagcau guacaaggac ucccagcccc gcgggauggc cgugaccauc      300

agcgugaagu gcgagaagau cuccacccug agcugcgaga acaagaucau cuccuucaag      360

gagaugaacc cgcccgacaa caucaaggac accaagagcg acaucaucuu cuuccagcgg      420

uccgugcccg gccacgacaa caagaugcag uucgagagcu ccagcuacga gggguacuuc      480

cucgccugcg agaaggagcg cgaccuguuc aagcugaucc ucaagaagga ggacgagcug      540

ggcgaccggu ccaucauguu cacgguccag aacgaggacu ga                         582


<210>  4292
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-18__Homo_sapiens__ACA06006

<400>  4292
auggccgccg agcccgucga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccucu acuucaucgg cgagcuccuc aagaaccucg aguccgacua cuucggcaag      120

cucgagucca agcucuccgu cauccgcaac cucaacgacc agguccucuu caucgaccag      180

ggcaaccgcc cccucuucga ggacaugacc gacuccgacu gccgcgacaa cgccccccgc      240

accaucuuca ucaucuccau guacaaggac ucccagcccc gcggcauggc cgucaccauc      300

uccgucaagu gcgagaagau cuccacccuc uccugcgaga acaagaucau cuccuucaag      360

gagaugaacc cccccgacaa caucaaggac accaaguccg acaucaucuu cuuccagcgc      420

uccguccccg gccacgacaa caagaugcag uucgaguccu ccuccuacga gggcuacuuc      480

cucgccugcg agaaggagcg cgaccucuuc aagcucaucc ucaagaagga ggacgagcuc      540

ggcgaccgcu ccaucauguu caccguccag aacgaggacu ga                         582


<210>  4293
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-18__Homo_sapiens__ACA06006

<400>  4293
auggccgcug agcccgugga agacaacugc aucaauuucg ucgcaaugaa guuuauugau       60

aacacccugu acuucauagg cgagcuccuu aaaaaucugg aaagcgacua uuuugggaag      120

uuggagucca aauuaucugu uaucagaaac cugaaugauc aggugcuauu cauugaccaa      180

ggaaacaggc cucucuuuga agauaugaca gacucagauu gucgggacaa ugccccacgc      240

acuaucuuca uuaucaguau guacaaggau agccagccgc gagguauggc gguaacgaua      300

uccgugaaau gcgagaagau cucuacccug ucgugugaga acaagauuau cucauuuaaa      360

gaaaugaauc ccccugacaa cauuaaggau acaaaaagcg acaucauauu cuuucagcgu      420

agugucccag gccacgauaa uaagaugcag uucgaguccu cuagcuauga aggguacuuu      480

cuugcuugcg agaaagagag agaccuguuc aaguugauuc ucaagaaaga agacgagcug      540

ggagauaggu ccaucauguu uacugugcaa aacgaagacu ga                         582


<210>  4294
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-18__Homo_sapiens__ACA06006

<400>  4294
auggccgccg agcccgugga ggacaacugc aucaacuucg uggccaugaa guucaucgac       60

aacacccugu acuucaucgg cgagcugcug aagaaccugg agagcgacua cuucggcaag      120

cuggagagca agcugagcgu gaucagaaac cugaacgacc aggugcuguu caucgaccag      180

ggcaacagac cccuguucga ggacaugacc gacagcgacu gcagagacaa cgcccccaga      240

accaucuuca ucaucagcau guacaaggac agccagccca gaggcauggc cgugaccauc      300

agcgugaagu gcgagaagau cagcacccug agcugcgaga acaagaucau cagcuucaag      360

gagaugaacc cccccgacaa caucaaggac accaagagcg acaucaucuu cuuccagaga      420

agcgugcccg gccacgacaa caagaugcag uucgagagca gcagcuacga gggcuacuuc      480

cuggccugcg agaaggagag agaccuguuc aagcugaucc ugaagaagga ggacgagcug      540

ggcgacagaa gcaucauguu caccgugcag aacgaggacu ga                         582


<210>  4295
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-18__Homo_sapiens__ACA06006

<400>  4295
auggccgcug agcccgugga agacaacugc aucaauuucg ucgccaugaa guuuauugau       60

aacacccugu acuucaucgg cgagcuccug aaaaaucuug aaagcgacua uuuugggaag      120

cuggagucca aacucucugu uauuagaaac cugaaugauc aggugcuuuu caucgaccaa      180

ggaaaccggc cucuguuuga agauaugaca gacagcgauu gucgcgacaa ugcgccgaga      240

acgauuuuca ucaucuccau guacaaggau ucucagcccc ggggcauggc ugugaccauu      300

agcgucaaau gcgagaagau cuccacacuc ucuugugaga acaagauuau cagcuuuaaa      360

gaaaugaauc cucccgacaa cauuaaggau accaaauccg acaucauuuu cuuucagcgc      420

agcgugccug ggcacgauaa uaagaugcag uucgagucuu ccagcuauga aggauacuuu      480

cuggccugcg agaaagagag agaccuguuc aagcucaucc ugaagaaaga agacgagcuu      540

ggcgaucggu cuaucauguu uacaguucaa aacgaagacu ga                         582


<210>  4296
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-18__Homo_sapiens__ACA06006

<400>  4296
auggcagcag aaccaguaga agacaacugc auaaacuucg uagcaaugaa auucauagac       60

aacacacuau acuucauagg agaacuacua aaaaaccuag aaucagacua cuucggaaaa      120

cuagaaucaa aacuauccgu aauaagaaac cuaaacgacc aaguacuauu cauagaccaa      180

ggaaacagac cacucuucga agacaugaca gacucagacu gcagagacaa cgcaccaaga      240

acaauauuca uaauaucaau guacaaagac ucacaaccaa gaggaauggc aguaaccaua      300

ucaguaaaau gcgaaaaaau aucaacacua ucaugcgaaa acaaaauaau aucauucaaa      360

gaaaugaacc caccagacaa cauaaaagac acaaaaucag acauaauauu cuuccaaaga      420

ucaguaccag gacacgacaa caaaaugcaa uucgaaagcu caucauacga aggauacuuc      480

cuagcaugcg aaaaagaaag agaccuauuc aaauuaauac uaaaaaaaga agacgaacua      540

ggagacagau caauaauguu cacaguccaa aacgaagacu aa                         582


<210>  4297
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__Q14116

<400>  4297

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  4298
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-18__Homo_sapiens__AAH07007

<400>  4298
auggcugcug aaccaguaga agacaauugc aucaacuuug uggcaaugaa auuuauugac       60

aauacgcuuu acuuuauagc ugaagaugau gaaaaccugg aauccgauua cuuuggcaag      120

cuugaaucua aauuaucagu cauaagaaau uugaaugacc aaguucucuu cauugaccaa      180

ggaaaucggc cucuauuuga agauaugacu gauucugacu guagagauaa ugcaccccgg      240

accauauuua uuauaaguau guauaaagau agccagccua gagguauggc uguaacuauc      300

ucugugaagu gugagaaaau uucaacucuc uccugugaga acaaaauuau uuccuuuaag      360

gaaaugaauc cuccugauaa caucaaggau acaaaaagug acaucauauu cuuucagaga      420

agugucccag gacaugauaa uaagaugcaa uuugaaucuu caucauacga aggauacuuu      480

cuagcuugug aaaaagagag agaccuuuuu aaacucauuu ugaaaaaaga ggaugaauug      540

ggggauagau cuauaauguu cacuguucaa aacgaagacu ag                         582


<210>  4299
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-18__Homo_sapiens__AAH07007

<400>  4299
auggccgccg agcccgugga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccugu acuucaucgc cgaggacgac gagaaccucg agagcgacua cuucggcaag      120

cuggagucca agcugagcgu gauccgcaac cucaacgacc aggugcuguu caucgaccag      180

gggaaccggc cgcuguucga ggacaugacc gacuccgacu gccgcgacaa cgcgccccgg      240

acgaucuuca ucaucagcau guacaaggac ucccagcccc gcggcauggc cgucaccauc      300

agcgugaagu gcgagaagau cuccacccuc agcugcgaga acaagaucau cuccuucaag      360

gagaugaacc cgcccgacaa caucaaggac accaagagcg acaucaucuu cuuccagcgg      420

uccgugcccg ggcacgacaa caagaugcag uucgagagcu ccagcuacga gggcuacuuc      480

cuggccugcg agaaggagcg cgaccuguuc aagcucaucc ugaagaagga ggacgagcug      540

ggggaccggu ccaucauguu cacgguccag aacgaggacu ga                         582


<210>  4300
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-18__Homo_sapiens__AAH07007

<400>  4300
auggccgccg agcccgucga ggacaacugc aucaacuucg ucgccaugaa guucaucgac       60

aacacccucu acuucaucgc cgaggacgac gagaaccucg aguccgacua cuucggcaag      120

cucgagucca agcucuccgu cauccgcaac cucaacgacc agguccucuu caucgaccag      180

ggcaaccgcc cccucuucga ggacaugacc gacuccgacu gccgcgacaa cgccccccgc      240

accaucuuca ucaucuccau guacaaggac ucccagcccc gcggcauggc cgucaccauc      300

uccgucaagu gcgagaagau cuccacccuc uccugcgaga acaagaucau cuccuucaag      360

gagaugaacc cccccgacaa caucaaggac accaaguccg acaucaucuu cuuccagcgc      420

uccguccccg gccacgacaa caagaugcag uucgaguccu ccuccuacga gggcuacuuc      480

cucgccugcg agaaggagcg cgaccucuuc aagcucaucc ucaagaagga ggacgagcuc      540

ggcgaccgcu ccaucauguu caccguccag aacgaggacu ga                         582


<210>  4301
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-18__Homo_sapiens__AAH07007

<400>  4301
auggccgcug agcccgugga agacaacugc aucaauuucg ucgcaaugaa guuuauugau       60

aacacccugu acuucauagc cgaggacgau gaaaaucucg agagcgacua uuuuggcaaa      120

cuugaaucca agcugucugu uaucagaaac uugaaugauc agguguuauu cauugaccaa      180

gggaacaggc cucuguuuga ggauaugaca gacucagauu gucgggacaa ugcgccacgc      240

acuaucuuca uuaucaguau guacaaagau agccagccgc gaggaauggc uguaacgaua      300

uccgugaagu gcgagaaaau cucuacccua ucgugugaaa acaagauuau cucauuuaag      360

gagaugaauc ccccugacaa cauuaaagau acaaagagcg acaucauauu cuuucagcgu      420

agugucccag gucacgacaa uaaaaugcag uucgaauccu cuagcuauga gggcuacuuu      480

cucgccugcg agaaggaaag agaucuguuc aaacuuauuc ugaagaagga ggacgaauug      540

ggggauaggu ccaucauguu uacugugcaa aacgaggacu ga                         582


<210>  4302
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-18__Homo_sapiens__AAH07007

<400>  4302
auggccgccg agcccgugga ggacaacugc aucaacuucg uggccaugaa guucaucgac       60

aacacccugu acuucaucgc cgaggacgac gagaaccugg agagcgacua cuucggcaag      120

cuggagagca agcugagcgu gaucagaaac cugaacgacc aggugcuguu caucgaccag      180

ggcaacagac cccuguucga ggacaugacc gacagcgacu gcagagacaa cgcccccaga      240

accaucuuca ucaucagcau guacaaggac agccagccca gaggcauggc cgugaccauc      300

agcgugaagu gcgagaagau cagcacccug agcugcgaga acaagaucau cagcuucaag      360

gagaugaacc cccccgacaa caucaaggac accaagagcg acaucaucuu cuuccagaga      420

agcgugcccg gccacgacaa caagaugcag uucgagagca gcagcuacga gggcuacuuc      480

cuggccugcg agaaggagag agaccuguuc aagcugaucc ugaagaagga ggacgagcug      540

ggcgacagaa gcaucauguu caccgugcag aacgaggacu ga                         582


<210>  4303
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-18__Homo_sapiens__AAH07007

<400>  4303
auggccgcug agcccgugga agacaacugc aucaauuucg ucgccaugaa guuuauugau       60

aacacccugu acuucaucgc ggaggacgau gaaaaucucg agagcgacua uuuuggcaaa      120

cuggaaucca agcucucugu uauuagaaac cugaaugauc aggugcuuuu caucgaccaa      180

gggaaccggc cucuguuuga ggauaugaca gacagcgauu gucgcgacaa ugcuccgaga      240

acgauuuuca ucaucuccau guacaaagau ucucagcccc ggggaauggc cgugaccauu      300

agcgucaagu gcgagaaaau cuccacacuu ucuugugaaa acaagauuau cagcuuuaag      360

gagaugaauc cucccgacaa cauuaaagau accaaguccg acaucauuuu cuuucagcgc      420

agcgugccug gccacgacaa uaaaaugcag uucgaaucuu ccagcuauga gggguacuuu      480

cuggccugcg agaaggaaag agaucucuuc aaacugaucc ugaagaagga ggacgaacuc      540

ggagaucggu cuaucauguu uacaguucaa aacgaggacu ga                         582


<210>  4304
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-18__Homo_sapiens__AAH07007

<400>  4304
auggcagcag aaccaguaga agacaacugc auaaacuucg uagcaaugaa auucaucgac       60

aacacacuau acuucauagc agaagacgau gaaaaccuag aaagcgacua cuucggaaaa      120

uuagaaucaa aacuaucagu aauaagaaac cuaaacgacc aaguacuauu cauagaccaa      180

ggaaacagac cacuauucga agacaugaca gacucagacu gcagagacaa cgcaccaaga      240

acaauauuca uaauaucaau guacaaagac agccaaccac gaggaauggc aguaacaaua      300

agcguaaaau gcgaaaaaau aucaacacua ucaugcgaaa acaaaauaau aucauucaaa      360

gaaaugaacc caccagauaa cauaaaagac acaaaaucag auauaauauu cuuccaaaga      420

ucaguaccag gacacgacaa caaaaugcaa uucgaaucau caucauacga aggauacuuc      480

cuagcaugcg aaaaagaacg agaccuauuc aaacuaauac uaaaaaaaga agacgaauua      540

ggagacagau caauaauguu cacaguacaa aacgaagacu aa                         582


<210>  4305
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-19__Homo_sapiens__Q9UHD0

<400>  4305

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
                165                 170                 175     


Ala 
    


<210>  4306
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-19__Homo_sapiens__CCDS1469.1

<400>  4306
augaaguuac aguguguuuc ccuuuggcuc cuggguacaa uacugauauu gugcucagua       60

gacaaccacg gucucaggag augucugauu uccacagaca ugcaccauau agaagagagu      120

uuccaagaaa ucaaaagagc cauccaagcu aaggacaccu ucccaaaugu cacuauccug      180

uccacauugg agacucugca gaucauuaag cccuuagaug ugugcugcgu gaccaagaac      240

cuccuggcgu ucuacgugga caggguguuc aaggaucauc aggagccaaa ccccaaaauc      300

uugagaaaaa ucagcagcau ugccaacucu uuccucuaca ugcagaaaac ucugcggcaa      360

ugucaggaac agaggcagug ucacugcagg caggaagcca ccaaugccac cagagucauc      420

caugacaacu augaucagcu ggagguccac gcugcugcca uuaaaucccu gggagagcuc      480

gacgucuuuc uagccuggau uaauaagaau caugaaguaa uguucucagc uuga            534


<210>  4307
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4307
augaagcugc agugcgugag ccucuggcug cugggcacca uccucauccu gugcuccguc       60

gacaaccacg ggcugcgccg gugccucauc agcaccgaca ugcaccacau cgaggagucc      120

uuccaggaga ucaagcgcgc cauccaggcc aaggacacgu uccccaacgu gaccauccug      180

agcacccugg agacccucca gaucaucaag ccgcuggacg ugugcugcgu cacgaagaac      240

cugcucgcgu ucuacgugga ccggguguuc aaggaccacc aggagcccaa ccccaagauc      300

cugcgcaaga ucuccagcau cgccaacucc uuccuguaca ugcagaagac ccuccggcag      360

ugccaggagc agcgccagug ccacugccgg caggaggcca ccaacgccac ccgcgucauc      420

cacgacaacu acgaccagcu ggaggugcac gccgcggcca ucaagagccu gggcgagcuc      480

gacguguucc uggccuggau caacaagaac cacgagguca uguucuccgc cuga            534


<210>  4308
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4308
augaagcucc agugcgucuc ccucuggcuc cucggcacca uccucauccu cugcuccguc       60

gacaaccacg gccuccgccg cugccucauc uccaccgaca ugcaccacau cgaggagucc      120

uuccaggaga ucaagcgcgc cauccaggcc aaggacaccu uccccaacgu caccauccuc      180

uccacccucg agacccucca gaucaucaag ccccucgacg ucugcugcgu caccaagaac      240

cuccucgccu ucuacgucga ccgcgucuuc aaggaccacc aggagcccaa ccccaagauc      300

cuccgcaaga ucuccuccau cgccaacucc uuccucuaca ugcagaagac ccuccgccag      360

ugccaggagc agcgccagug ccacugccgc caggaggcca ccaacgccac ccgcgucauc      420

cacgacaacu acgaccagcu cgagguccac gccgccgcca ucaagucccu cggcgagcuc      480

gacgucuucc ucgccuggau caacaagaac cacgagguca uguucuccgc cuga            534


<210>  4309
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4309
augaagcugc agugcgugag ccucuggcuu cugggcacca ucuugauuuu auguuccguc       60

gacaaccacg ggcugagaag gugccuaaua ucuacagaua ugcaucacau cgaggaauca      120

uuccaagaga uuaaacgggc cauccaggcu aaggacacuu uucccaaugu uacgauucuc      180

aguacccugg aaacacuuca gaucauaaaa ccucuggaug uguguugcgu aacuaagaac      240

uugcucgcau ucuacgugga ccgcgucuuu aaagaucauc aggagccaaa uccgaagauc      300

cugcgaaaga uuagcuccau cgccaacucu uuccuguaua ugcagaaaac ccuccgucaa      360

ugucaggaac agagacaaug ccacuguagg caggaggcga caaaugcuac ccgggugauu      420

caugacaacu acgaucaguu agagguucac gccgcagcca ucaagucgcu gggagaacuu      480

gacguguuuu uggcuuggau aaauaaaaac cacgagguca uguucucagc auga            534


<210>  4310
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4310
augaagcugc agugcgugag ccuguggcug cugggcacca uccugauccu gugcagcgug       60

gacaaccacg gccugagaag augccugauc agcaccgaca ugcaccacau cgaggagagc      120

uuccaggaga ucaagagagc cauccaggcc aaggacaccu uccccaacgu gaccauccug      180

agcacccugg agacccugca gaucaucaag ccccuggacg ugugcugcgu gaccaagaac      240

cugcuggccu ucuacgugga cagaguguuc aaggaccacc aggagcccaa ccccaagauc      300

cugagaaaga ucagcagcau cgccaacagc uuccuguaca ugcagaagac ccugagacag      360

ugccaggagc agagacagug ccacugcaga caggaggcca ccaacgccac cagagugauc      420

cacgacaacu acgaccagcu ggaggugcac gccgccgcca ucaagagccu gggcgagcug      480

gacguguucc uggccuggau caacaagaac cacgagguga uguucagcgc cuga            534


<210>  4311
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4311
augaagcugc agugcgugag ccucuggcug cuuggcacca uccugauucu cuguuccguc       60

gacaaccacg ggcugagacg gugccuuauc ucuacagaua ugcaucacau ugaggagagc      120

uuccaagaaa ucaaacgcgc cauucaggcu aaggacacgu uucccaaugu uaccauccug      180

uccacacucg aaacccugca gaucauuaaa ccucuggaug uguguugcgu gacaaagaac      240

cuccuggccu ucuacgucga cagaguguuu aaagaucauc aggagccgaa ucccaagauc      300

cuucggaaga uuucuagcau cgcgaacucc uuccuguaua ugcagaaaac ccuccgccaa      360

ugucaggaac agagacaaug ccacugucgg caggaggcua caaaugccac ccgcguuauu      420

caugacaacu acgaucagcu ggaggugcac gccgcugcca ucaagucucu uggagaacug      480

gacgucuuuc ucgcuuggau uaauaaaaac cacgagguga uguucagcgc cuga            534


<210>  4312
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-19__Homo_sapiens__CCDS1469.1

<400>  4312
augaaacuac aaugcguauc acuauggcua cuaggaacaa uacuaauacu augcucagua       60

gacaaucacg gacuaagaag augccuaaua ucaacagaca ugcaccacau agaagaauca      120

uuucaagaaa uaaaaagagc aauacaagca aaagacacau ucccaaacgu aacaauacua      180

ucaacacuag aaacacuaca aauaauaaaa ccacucgacg uaugcugcgu aacaaaaaac      240

uuacuagcau ucuacguaga cagagucuuc aaagaccacc aagaaccaaa cccaaaaaua      300

cuaagaaaaa uaucaagcau agccaacuca uuccuauaca ugcaaaaaac acuaagacaa      360

ugccaagaac aaagacaaug ccacugcaga caagaagcaa caaacgcaac aagaguaaua      420

cacgacaacu acgaccaauu agaaguacac gcagcagcaa uaaaaucacu aggagaacua      480

gacguauucc uagcauggau aaacaaaaac caugaaguaa uguucucagc auaa            534


<210>  4313
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1_alpha__Homo_sapiens__P01583

<400>  4313

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  4314
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1_alpha__Homo_sapiens__AAA59133

<400>  4314
auggccaaag uuccagacau guuugaagac cugaagaacu guuacaguga aaaugaagaa       60

gacaguuccu ccauugauca ucugucucug aaucagaaau ccuucuauca uguaagcuau      120

ggcccacucc augaaggcug cauggaucaa ucugugucuc ugaguaucuc ugaaaccucu      180

aaaacaucca agcuuaccuu caaggagagc auggugguag uagcaaccaa cgggaagguu      240

cugaagaaga gacgguugag uuuaagccaa uccaucacug augaugaccu ggaggccauc      300

gccaaugacu cagaggaaga aaucaucaag ccuaggucag caccuuuuag cuuccugagc      360

aaugugaaau acaacuuuau gaggaucauc aaauacgaau ucauccugaa ugacgcccuc      420

aaucaaagua uaauucgagc caaugaucag uaccucacgg cugcugcauu acauaaucug      480

gaugaagcag ugaaauuuga caugggugcu uauaagucau caaaggauga ugcuaaaauu      540

accgugauuc uaagaaucuc aaaaacucaa uuguauguga cugcccaaga ugaagaccaa      600

ccagugcugc ugaaggagau gccugagaua cccaaaacca ucacagguag ugagaccaac      660

cuccucuucu ucugggaaac ucacggcacu aagaacuauu ucacaucagu ugcccaucca      720

aacuuguuua uugccacaaa gcaagacuac ugggugugcu uggcaggggg gccacccucu      780

aucacugacu uucagauacu ggaaaaccag gcguag                                816


<210>  4315
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4315
auggccaagg ugcccgacau guucgaggac cugaagaacu gcuacagcga gaacgaggag       60

gacuccagcu ccaucgacca ccucagccug aaccagaagu ccuucuacca cgucagcuac      120

ggcccgcugc acgagggcug cauggaccag uccgugagcc ucuccaucag cgagaccucc      180

aagaccagca agcugacguu caaggagucc augguggucg uggccaccaa cggcaaggug      240

cugaagaagc gccggcucag ccugucccag agcaucaccg acgacgaccu ggaggcgauc      300

gccaacgacu ccgaggagga gaucaucaag ccccgcagcg cccccuucuc cuuccucagc      360

aacgucaagu acaacuucau gcggaucauc aaguacgagu ucauccugaa cgacgcccug      420

aaccagagca ucauccgcgc caacgaccag uaccucaccg cggccgcccu gcacaaccug      480

gacgaggccg ugaaguucga caugggggcg uacaagucca gcaaggacga cgccaagauc      540

acggugaucc uccggaucuc caagacccag cuguacguca ccgcccagga cgaggaccag      600

cccgugcugc ucaaggagau gccggagauc cccaagacca ucacgggcag cgagaccaac      660

cugcuguucu ucugggagac ccacgggacc aagaacuacu ucacguccgu ggcccacccc      720

aaccucuuca ucgccaccaa gcaggacuac ugggucugcc uggcgggcgg gcccccgagc      780

aucaccgacu uccagauccu ggagaaccag gccuga                                816


<210>  4316
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4316
auggccaagg uccccgacau guucgaggac cucaagaacu gcuacuccga gaacgaggag       60

gacuccuccu ccaucgacca ccucucccuc aaccagaagu ccuucuacca cgucuccuac      120

ggcccccucc acgagggcug cauggaccag uccgucuccc ucuccaucuc cgagaccucc      180

aagaccucca agcucaccuu caaggagucc auggucgucg ucgccaccaa cggcaagguc      240

cucaagaagc gccgccucuc ccucucccag uccaucaccg acgacgaccu cgaggccauc      300

gccaacgacu ccgaggagga gaucaucaag ccccgcuccg cccccuucuc cuuccucucc      360

aacgucaagu acaacuucau gcgcaucauc aaguacgagu ucauccucaa cgacgcccuc      420

aaccagucca ucauccgcgc caacgaccag uaccucaccg ccgccgcccu ccacaaccuc      480

gacgaggccg ucaaguucga caugggcgcc uacaaguccu ccaaggacga cgccaagauc      540

accgucaucc uccgcaucuc caagacccag cucuacguca ccgcccagga cgaggaccag      600

cccguccucc ucaaggagau gcccgagauc cccaagacca ucaccggcuc cgagaccaac      660

cuccucuucu ucugggagac ccacggcacc aagaacuacu ucaccuccgu cgcccacccc      720

aaccucuuca ucgccaccaa gcaggacuac ugggucugcc ucgccggcgg cccccccucc      780

aucaccgacu uccagauccu cgagaaccag gccuga                                816


<210>  4317
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4317
auggccaagg ugcccgacau guucgaggau cugaaaaacu gcuacagcga aaaugaggaa       60

gacuccucuu caaucgauca ccucagucuu aaccaaaaga gcuuuuauca ugucuccuac      120

ggcccucugc acgaggggug uauggaccag ucuguuucgu ugucaauuag cgaaaccagu      180

aaaacaucca aguuaacuuu caaagagucu auggugguag uggcuacgaa uggaaagguc      240

cugaagaaaa gaaggcuaag ccucucccag ucaauaaccg augacgaucu ggaggcaauc      300

gccaacgaca gugaagagga aauuaucaag ccacggagcg cgccguuuuc uuuccuuucc      360

aaugugaaau auaacuuuau gcgcauuauc aaguacgagu ucauacugaa ugaugcuuug      420

aaccagucaa ucauucgagc caaugaccag uaucucacag cagccgcucu gcauaaccug      480

gaugaggcag uuaaauuuga caugggugcc uacaagagca guaaggauga cgcuaaaauc      540

acugugauuc uccguaucuc uaagacccaa uuauauguca cagcccagga cgaagaucag      600

cccgugcugc uuaaagagau gccugaaaua ccaaagacca uuacuggcuc cgagacaaau      660

uugcuguucu uuugggaaac ccacgggacg aaaaacuacu ucacuagcgu agcgcauccc      720

aaucuauuua ucgcaaccaa gcaggacuac uggguuugcc ucgccggagg cccuccaucg      780

auuacagauu uccaaauccu ggagaaccag gcuuga                                816


<210>  4318
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4318
auggccaagg ugcccgacau guucgaggac cugaagaacu gcuacagcga gaacgaggag       60

gacagcagca gcaucgacca ccugagccug aaccagaaga gcuucuacca cgugagcuac      120

ggcccccugc acgagggcug cauggaccag agcgugagcc ugagcaucag cgagaccagc      180

aagaccagca agcugaccuu caaggagagc augguggugg uggccaccaa cggcaaggug      240

cugaagaaga gaagacugag ccugagccag agcaucaccg acgacgaccu ggaggccauc      300

gccaacgaca gcgaggagga gaucaucaag cccagaagcg cccccuucag cuuccugagc      360

aacgugaagu acaacuucau gagaaucauc aaguacgagu ucauccugaa cgacgcccug      420

aaccagagca ucaucagagc caacgaccag uaccugaccg ccgccgcccu gcacaaccug      480

gacgaggccg ugaaguucga caugggcgcc uacaagagca gcaaggacga cgccaagauc      540

accgugaucc ugagaaucag caagacccag cuguacguga ccgcccagga cgaggaccag      600

cccgugcugc ugaaggagau gcccgagauc cccaagacca ucaccggcag cgagaccaac      660

cugcuguucu ucugggagac ccacggcacc aagaacuacu ucaccagcgu ggcccacccc      720

aaccuguuca ucgccaccaa gcaggacuac ugggugugcc uggccggcgg cccccccagc      780

aucaccgacu uccagauccu ggagaaccag gccuga                                816


<210>  4319
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4319
auggccaagg ugcccgacau guucgaggau cugaaaaacu gcuacagcga aaaugaggaa       60

gacuccucua gcaucgauca ccucucccug aaccagaagu cuuuuuauca ugucagcuac      120

ggcccucuuc acgaggggug uauggaccaa uccguuucuc ugagcauuuc cgaaaccagc      180

aaaacaucua agcucacguu caaagagucc augguggugg ucgcuaccaa uggaaaggug      240

cugaagaaaa gacggcuuag ccugucucag uccaucacag augacgaucu cgaggccauu      300

gcgaacgaca gcgaagagga aaucauuaag ccgcgcucug cucccuuuuc cuuccugagc      360

aauguuaaau auaacuuuau gagaaucauc aaguacgagu ucauucugaa ugaugcccuc      420

aaccagucca ucauucgggc caaugaccag uaucugaccg cugccgcccu ucauaaccug      480

gaugaggcug ugaaauuuga caugggcgcg uacaagucua gcaaggauga cgccaaaauc      540

acagucauuc uccgcaucuc caagacccaa cuguauguga cagcucagga cgaagaucag      600

ccuguucuuc ugaaagagau gcccgaaauu ccuaagacca ucacggggag cgagaccaau      660

cuccuguucu uuugggaaac acacggaacc aaaaacuacu ucacaucugu ggcccauccc      720

aaucuguuua ucgcuaccaa gcaggacuac ugggucugcc ucgccggcgg gccuccgucc      780

auuacggauu uccaaauccu ggagaaccag gcguga                                816


<210>  4320
<211>  816
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-1_alpha__Homo_sapiens__AAA59133

<400>  4320
auggcaaaag uaccagacau guucgaagac uuaaaaaauu gcuacucaga aaacgaagaa       60

gacucaucau ccauagacca ccuaucacua aaccaaaaau ccuucuauca cguaucauac      120

ggaccacuac acgaaggaug cauggaccaa ucaguaucac uaucuauauc agaaacauca      180

aaaacaucaa aacuaacauu caaagaauca augguaguag uagcaacaaa cggaaaagua      240

uuaaaaaaaa gaagauuauc acuaucacaa uccauaacag acgacgaccu agaagccaua      300

gcaaaugacu cagaagaaga aauaauaaaa ccacgaucag caccauuuuc auuccuauca      360

aauguaaaau acaauuucau gcgaauaaua aaauacgaau ucauauuaaa cgacgcacua      420

aaccaaucaa uaauaagagc caacgaccaa uaccuaacug cagcagcacu acacaaccuc      480

gacgaagcag uaaaauucga caugggagcc uauaaaucau caaaagacga cgcaaaaaua      540

acagucauau uaagaauauc aaaaacacaa uuauacguaa cagcacaaga cgaagaccaa      600

ccaguacuac uaaaagaaau gccugaaaua ccaaaaacaa uaacaggauc agaaacaaac      660

uuauuauucu ucugggaaac acacggaaca aaaaacuacu ucacaucugu agcacaccca      720

aaccuauuca uagcaaccaa acaagacuac uggguaugcc uagcuggagg cccaccaucc      780

aucacagacu uccaaauacu agaaaaccaa gcauaa                                816


<210>  4321
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1_beta__Homo_sapiens__P01584

<400>  4321

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  4322
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1_beta__Homo_sapiens__AAA59135

<400>  4322
auggcagaag uaccugagcu cgccagugaa augauggcuu auuacagugg caaugaggau       60

gacuuguucu uugaagcuga uggcccuaaa cagaugaagu gcuccuucca ggaccuggac      120

cucugcccuc uggauggcgg cauccagcua cgaaucuccg accaccacua cagcaagggc      180

uucaggcagg ccgcgucagu uguuguggcc auggacaagc ugaggaagau gcugguuccc      240

ugcccacaga ccuuccagga gaaugaccug agcaccuucu uucccuucau cuuugaagaa      300

gaaccuaucu ucuucgacac augggauaac gaggcuuaug ugcacgaugc accuguacga      360

ucacugaacu gcacgcuccg ggacucacag caaaaaagcu uggugauguc ugguccauau      420

gaacugaaag cucuccaccu ccagggacag gauauggagc aacaaguggu guucuccaug      480

uccuuuguac aaggagaaga aaguaaugac aaaauaccug uggccuuggg ccucaaggaa      540

aagaaucugu accuguccug cguguugaaa gaugauaagc ccacucuaca gcuggagagu      600

guagauccca aaaauuaccc aaagaagaag auggaaaagc gauuugucuu caacaagaua      660

gaaaucaaua acaagcugga auuugagucu gcccaguucc ccaacuggua caucagcacc      720

ucucaagcag aaaacaugcc cgucuuccug ggagggacca aaggcggcca ggauauaacu      780

gacuucacca ugcaauuugu gucuuccuaa                                       810


<210>  4323
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4323
auggccgagg ugcccgagcu ggccagcgag augauggcgu acuacuccgg caacgaggac       60

gaccucuucu ucgaggccga cgggccgaag cagaugaagu gcagcuucca ggaccuggac      120

cugugccccc ucgacggcgg gauccagcug cgcaucuccg accaccacua cagcaagggc      180

uuccggcagg ccgccuccgu cgugguggcc auggacaagc ugcgcaagau gcucgucccc      240

ugcccccaga ccuuccagga gaacgaccug agcaccuucu ucccguucau cuucgaggag      300

gagcccaucu ucuucgacac gugggacaac gaggcguacg ugcacgacgc ccccgugcgg      360

ucccugaacu gcacccuccg cgacagccag cagaaguccc uggucaugag cgggcccuac      420

gagcugaagg cccuccaccu ccagggccag gacauggagc agcaggucgu guucuccaug      480

agcuucgugc agggcgagga guccaacgac aagaucccgg uggcccuggg gcugaaggag      540

aagaaccugu accugagcug cgugcucaag gacgacaagc ccacccugca gcuggagucc      600

gucgacccca agaacuaccc caagaagaag auggagaagc gguucguguu caacaagauc      660

gagaucaaca acaagcucga guucgagagc gcgcaguucc cgaacuggua caucuccacc      720

agccaggccg agaacaugcc cguguuccug ggcgggacga agggcgggca ggacaucacc      780

gacuucacca ugcaguucgu cuccagcuga                                       810


<210>  4324
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4324
auggccgagg uccccgagcu cgccuccgag augauggccu acuacuccgg caacgaggac       60

gaccucuucu ucgaggccga cggccccaag cagaugaagu gcuccuucca ggaccucgac      120

cucugccccc ucgacggcgg cauccagcuc cgcaucuccg accaccacua cuccaagggc      180

uuccgccagg ccgccuccgu cgucgucgcc auggacaagc uccgcaagau gcucgucccc      240

ugcccccaga ccuuccagga gaacgaccuc uccaccuucu uccccuucau cuucgaggag      300

gagcccaucu ucuucgacac cugggacaac gaggccuacg uccacgacgc ccccguccgc      360

ucccucaacu gcacccuccg cgacucccag cagaaguccc ucgucauguc cggccccuac      420

gagcucaagg cccuccaccu ccagggccag gacauggagc agcaggucgu cuucuccaug      480

uccuucgucc agggcgagga guccaacgac aagauccccg ucgcccucgg ccucaaggag      540

aagaaccucu accucuccug cguccucaag gacgacaagc ccacccucca gcucgagucc      600

gucgacccca agaacuaccc caagaagaag auggagaagc gcuucgucuu caacaagauc      660

gagaucaaca acaagcucga guucgagucc gcccaguucc ccaacuggua caucuccacc      720

ucccaggccg agaacaugcc cgucuuccuc ggcggcacca agggcggcca ggacaucacc      780

gacuucacca ugcaguucgu cuccuccuga                                       810


<210>  4325
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4325
auggccgagg ugcccgaacu ggcuagcgag augauggcau acuauuccgg caacgaagac       60

gaucucuucu uugaggccga cgggccuaag cagaugaaau gcucuuucca agaucuugac      120

cuguguccau uggauggagg uauccaguua agaauuucag accaccauua caguaagggc      180

uuuaggcagg cggcuagcgu cguuguggcc auggauaaac ugcggaagau gcuaguaccg      240

ugcccccaga ccuuccaaga aaaugaccuc uccacauuuu ucccuuuuau auucgaggag      300

gaaccaaucu uuuucgauac uugggacaac gaggcauaug ugcacgaugc ccccguccgc      360

ucucugaauu guacgcuucg agacucgcag cagaaaucac uggugaugag cgggccuuac      420

gaauugaagg cucuccaucu gcagggacaa gauauggagc agcagguugu guuuaguaug      480

uccuucgucc agggcgagga aucuaacgac aagauuccag uggcacuggg ucucaaagag      540

aagaauuuau aucugagcug cguacuuaaa gacgauaagc ccaccuugca acuggaaucc      600

guugacccua aaaacuaccc aaagaagaaa auggagaagc guuuuguguu caauaaaauc      660

gaaauuaaca auaagcuaga guucgaguca gcccaguuuc cgaacuggua uaucaguaca      720

agccaggcug aaaauaugcc cgucuuccuc gggggaacua aaggcggcca agauauaacc      780

gacuuuacaa ugcaguucgu gucuuccuga                                       810


<210>  4326
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4326
auggccgagg ugcccgagcu ggccagcgag augauggccu acuacagcgg caacgaggac       60

gaccuguucu ucgaggccga cggccccaag cagaugaagu gcagcuucca ggaccuggac      120

cugugccccc uggacggcgg cauccagcug agaaucagcg accaccacua cagcaagggc      180

uucagacagg ccgccagcgu ggugguggcc auggacaagc ugagaaagau gcuggugccc      240

ugcccccaga ccuuccagga gaacgaccug agcaccuucu uccccuucau cuucgaggag      300

gagcccaucu ucuucgacac cugggacaac gaggccuacg ugcacgacgc ccccgugaga      360

agccugaacu gcacccugag agacagccag cagaagagcc uggugaugag cggccccuac      420

gagcugaagg cccugcaccu gcagggccag gacauggagc agcagguggu guucagcaug      480

agcuucgugc agggcgagga gagcaacgac aagauccccg uggcccuggg ccugaaggag      540

aagaaccugu accugagcug cgugcugaag gacgacaagc ccacccugca gcuggagagc      600

guggacccca agaacuaccc caagaagaag auggagaaga gauucguguu caacaagauc      660

gagaucaaca acaagcugga guucgagagc gcccaguucc ccaacuggua caucagcacc      720

agccaggccg agaacaugcc cguguuccug ggcggcacca agggcggcca ggacaucacc      780

gacuucacca ugcaguucgu gagcagcuga                                       810


<210>  4327
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4327
auggccgagg ugcccgaacu ggcuagcgag augauggccu acuauuccgg caacgaagac       60

gaucucuucu uugaggcgga cgggccuaag cagaugaaau gcucuuucca agaucuggac      120

cuuuguccgc uggauggagg cauccagcuc agaauuagcg accaccauua cuccaagggg      180

uuucggcagg cugccucugu cguuguggcc auggauaaac ugcgcaagau gcuugugccc      240

ugcccucaga ccuuccaaga aaaugaccug agcacauuuu uccccuuuau cuucgaggag      300

gaaccuaucu uuuucgauac gugggacaac gaggcuuaug uccacgaugc ccccgugaga      360

ucccucaauu guacccugcg ggacucucag cagaaaagcc ugguuauguc cggaccuuac      420

gaacucaagg cucugcaucu ucagggccaa gauauggagc aacagguggu cuuuagcaug      480

ucuuucgugc agggggagga auccaacgac aagauuccgg uugcccuggg acucaaagag      540

aagaaucugu aucuuagcug cgugcugaaa gacgauaagc ccacacucca gcuggaaucu      600

gucgacccua aaaacuaccc caagaagaaa auggagaagc gcuuuguguu caauaaaauu      660

gaaaucaaca auaagcugga guucgagucc gcgcaguuuc cuaacuggua uaucagcacc      720

ucucaggccg aaaauaugcc cguguuccuc ggcggcacaa aagggggaca agauauuacc      780

gacuuuacaa ugcaguucgu cuccagcuga                                       810


<210>  4328
<211>  810
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-1_beta__Homo_sapiens__AAA59135

<400>  4328
auggcagaag uaccagaauu agcaucagaa augauggcau auuacucagg aaacgaagau       60

gaucuauucu ucgaagcaga cggaccaaaa caaaugaaau guagcuucca agaccuagac      120

cuauguccac uagauggcgg aauacaacua agaauaucag accaccacua cucaaaagga      180

uuccgacaag cagcaucagu aguaguagcu auggacaaau uaagaaaaau gcuaguacca      240

ugcccacaaa cauuccaaga aaacgaccua ucaacauucu ucccauucau auucgaagaa      300

gaaccaauau ucuucgacac cugggacaac gaagccuaug uacacgacgc accaguaaga      360

ucacuaaacu gcacauuacg agacucacaa caaaaaucac uagucauguc aggacccuac      420

gaacuaaaag cacuacacuu acaaggacaa gacauggaac aacaaguagu auucucaaug      480

ucauuuguac aaggagaaga aucaaacgau aaaauaccag uagcacuagg acucaaagaa      540

aaaaaccuau aucuaucaug uguauuaaaa gaugacaaac caacauuaca acuagaauca      600

gucgauccaa aaaacuaccc aaaaaaaaaa auggaaaaaa gauucguauu caacaaaaua      660

gaaauaaaca auaaacuaga auucgaaucc gcacaauucc caaacuggua cauaucaaca      720

ucccaagcag aaaacaugcc aguauuccua ggaggaacaa aaggaggaca agacauaaca      780

gacuucacaa ugcaauucgu aucaucauaa                                       810


<210>  4329
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__P18510-2

<400>  4329

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  4330
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4330
auggcuuuag agacgaucug ccgacccucu gggagaaaau ccagcaagau gcaagccuuc       60

agaaucuggg auguuaacca gaagaccuuc uaucugagga acaaccaacu aguugcugga      120

uacuugcaag gaccaaaugu caauuuagaa gaaaagauag augugguacc cauugagccu      180

caugcucugu ucuugggaau ccauggaggg aagaugugcc uguccugugu caagucuggu      240

gaugagacca gacuccagcu ggaggcaguu aacaucacug accugagcga gaacagaaag      300

caggacaagc gcuucgccuu cauccgcuca gacaguggcc ccaccaccag uuuugagucu      360

gccgccugcc ccgguugguu ccucugcaca gcgauggaag cugaccagcc cgucagccuc      420

accaauaugc cugacgaagg cgucaugguc accaaauucu acuuccagga ggacgaguag      480


<210>  4331
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4331
auggcccugg agaccaucug ccgccccagc ggccggaagu ccagcaagau gcaggccuuc       60

cgcaucuggg acgugaacca gaagaccuuc uaccuccgga acaaccagcu ggucgcgggg      120

uaccugcagg gcccgaacgu gaaccucgag gagaagaucg acgugguccc caucgagccc      180

cacgcccugu uccuggggau ccacggcggg aagaugugcc ucuccugcgu caagagcggc      240

gacgagacgc gccugcagcu ggaggccgug aacaucaccg accucuccga gaaccggaag      300

caggacaagc gcuucgccuu cauccggagc gacuccggcc ccaccaccag cuucgagucc      360

gccgcgugcc cggggugguu ccugugcacg gccauggagg ccgaccagcc cgugagccug      420

accaacaugc ccgacgaggg cgugauggug accaaguucu acuuccagga ggacgaguga      480


<210>  4332
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4332
auggcccucg agaccaucug ccgccccucc ggccgcaagu ccuccaagau gcaggccuuc       60

cgcaucuggg acgucaacca gaagaccuuc uaccuccgca acaaccagcu cgucgccggc      120

uaccuccagg gccccaacgu caaccucgag gagaagaucg acgucguccc caucgagccc      180

cacgcccucu uccucggcau ccacggcggc aagaugugcc ucuccugcgu caaguccggc      240

gacgagaccc gccuccagcu cgaggccguc aacaucaccg accucuccga gaaccgcaag      300

caggacaagc gcuucgccuu cauccgcucc gacuccggcc ccaccaccuc cuucgagucc      360

gccgccugcc ccggcugguu ccucugcacc gccauggagg ccgaccagcc cgucucccuc      420

accaacaugc ccgacgaggg cgucaugguc accaaguucu acuuccagga ggacgaguga      480


<210>  4333
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4333
auggcccugg agaccaucug cagacccagc ggcaggaagu ccucuaaaau gcaggcuuuc       60

cggauuuggg acgugaacca aaagacauuu uaccuccgca auaaccagcu ugucgcaggg      120

uaucugcagg gaccuaaugu uaacuuggaa gagaaaauag augugguacc aaucgaaccg      180

cacgccuuau uccuggguau ucauggcggg aagauguguc uaucaugcgu gaaaagugga      240

gacgagacuc gacuccagcu ggaagcgguc aauaucacgg aucuuagcga gaaccguaag      300

caagacaaga gauuugcuuu cauuaggucc gauucuggcc ccaccacauc guuugaguca      360

gccgcauguc cugguugguu ccugugcacu gccauggaag cugaccagcc agugagcuug      420

accaauaugc ccgaugaggg gguuauggug acaaaauuuu acuuccagga agacgaguga      480


<210>  4334
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4334
auggcccugg agaccaucug cagacccagc ggcagaaaga gcagcaagau gcaggccuuc       60

agaaucuggg acgugaacca gaagaccuuc uaccugagaa acaaccagcu gguggccggc      120

uaccugcagg gccccaacgu gaaccuggag gagaagaucg acguggugcc caucgagccc      180

cacgcccugu uccugggcau ccacggcggc aagaugugcc ugagcugcgu gaagagcggc      240

gacgagacca gacugcagcu ggaggccgug aacaucaccg accugagcga gaacagaaag      300

caggacaaga gauucgccuu caucagaagc gacagcggcc ccaccaccag cuucgagagc      360

gccgccugcc ccggcugguu ccugugcacc gccauggagg ccgaccagcc cgugagccug      420

accaacaugc ccgacgaggg cgugauggug accaaguucu acuuccagga ggacgaguga      480


<210>  4335
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4335
auggcccugg agaccaucug cagacccagc ggccggaagu ccucuaaaau gcaggcuuuc       60

cgcauuuggg acgugaacca aaagacauuu uaccucagaa auaaccagcu ggucgccggg      120

uaucuucagg gaccuaaugu uaaccuggaa gagaaaaucg auguggugcc gauugaaccc      180

cacgcucucu uccugggcau ccauggggga aagauguguc uuagcugcgu caaauccggc      240

gacgagacgc ggcugcagcu cgaagcggug aauauuaccg aucugucuga gaaccgcaag      300

caagacaaga gauuugccuu cauccggagc gauuccgggc cuacaaccuc uuuugagagc      360

gccgcuuguc ccggaugguu ccugugcaca gccauggaag cugaccagcc uguuucccuc      420

accaauaugc ccgaugaggg cgugaugguc acaaaauuuu acuuccagga agacgaguga      480


<210>  4336
<211>  480
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2113.1

<400>  4336
auggcacuag aaacaauaug cagaccauca ggaagaaaau caucaaaaau gcaagcauuc       60

agaauauggg acguaaacca aaaaacauuc uauuuaagaa acaaccaacu aguagcagga      120

uacuuacaag gaccaaacgu aaaccuagaa gaaaaaauag acguaguacc aauagaacca      180

cacgcacuau uccuaggaau acacggagga aaaaugugcc uaagcugcgu aaaaucagga      240

gacgaaacaa gauuacaauu agaagccgua aacauaacag accuaucaga aaacagaaaa      300

caagacaaaa gauucgcauu cauaagauca gacucaggac caacaacauc auucgaauca      360

gcagcaugcc caggaugguu ccuauguaca gcaauggaag cagaccaacc aguaucacua      420

acaaacaugc cagacgaagg aguaauggua acaaaauucu acuuccaaga agacgaauaa      480


<210>  4337
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__P18510-3

<400>  4337

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  4338
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4338
auggcuuuag cugacuugua ugaagaagga gguggaggag gaggagaagg ugaagacaau       60

gcugacucaa aggagacgau cugccgaccc ucugggagaa aauccagcaa gaugcaagcc      120

uucagaaucu gggauguuaa ccagaagacc uucuaucuga ggaacaacca acuaguugcu      180

ggauacuugc aaggaccaaa ugucaauuua gaagaaaaga uagauguggu acccauugag      240

ccucaugcuc uguucuuggg aauccaugga gggaagaugu gccuguccug ugucaagucu      300

ggugaugaga ccagacucca gcuggaggca guuaacauca cugaccugag cgagaacaga      360

aagcaggaca agcgcuucgc cuucauccgc ucagacagug gccccaccac caguuuugag      420

ucugccgccu gccccgguug guuccucugc acagcgaugg aagcugacca gcccgucagc      480

cucaccaaua ugccugacga aggcgucaug gucaccaaau ucuacuucca ggaggacgag      540

uag                                                                    543


<210>  4339
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4339
auggcccugg ccgaccucua cgaggagggc gggggcgggg gcggggaggg cgaggacaac       60

gcggacagca aggagaccau cugccgcccc uccggccgca agagcuccaa gaugcaggcc      120

uuccggaucu gggacgugaa ccagaagacc uucuaccugc ggaacaacca gcuggucgcc      180

ggguaccucc agggcccgaa cgugaaccug gaggagaaga ucgacguggu ccccaucgag      240

ccccacgccc uguuccucgg gauccacggc gggaagaugu gccugagcug cgugaagucc      300

ggcgacgaga cgcgccugca gcucgaggcc gugaacauca ccgaccugag cgagaaccgg      360

aagcaggaca agcgcuucgc guucauccgg uccgacagcg gccccaccac cuccuucgag      420

agcgccgccu gcccggggug guuccugugc acggccaugg aggcggacca gcccgucucc      480

cucaccaaca ugcccgacga gggcgugaug gugaccaagu ucuacuucca ggaggacgag      540

uga                                                                    543


<210>  4340
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4340
auggcccucg ccgaccucua cgaggagggc ggcggcggcg gcggcgaggg cgaggacaac       60

gccgacucca aggagaccau cugccgcccc uccggccgca aguccuccaa gaugcaggcc      120

uuccgcaucu gggacgucaa ccagaagacc uucuaccucc gcaacaacca gcucgucgcc      180

ggcuaccucc agggccccaa cgucaaccuc gaggagaaga ucgacgucgu ccccaucgag      240

ccccacgccc ucuuccucgg cauccacggc ggcaagaugu gccucuccug cgucaagucc      300

ggcgacgaga cccgccucca gcucgaggcc gucaacauca ccgaccucuc cgagaaccgc      360

aagcaggaca agcgcuucgc cuucauccgc uccgacuccg gccccaccac cuccuucgag      420

uccgccgccu gccccggcug guuccucugc accgccaugg aggccgacca gcccgucucc      480

cucaccaaca ugcccgacga gggcgucaug gucaccaagu ucuacuucca ggaggacgag      540

uga                                                                    543


<210>  4341
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4341
auggcccugg cugaccucua cgaggaaggc gggggaggug gcggggaggg agaagauaac       60

gcagacagca aggagaccau cugcagaccc uccggcagga aaucuucaaa gaugcaggcc      120

uuccggauuu gggaugugaa ucaaaagaca uuuuaucuuc gcaacaauca gcuggucgcg      180

gguuacuugc aggggccuaa cguuaauuua gaagagaaga uagacguggu accaaucgag      240

ccgcacgcuc uguuccuagg cauucaugga ggcaaaaugu gucucaguug cgugaaaagc      300

ggggaugaaa cucgacugca gcuugaggcc gucaacauca cggaccuguc cgaaaaucgu      360

aagcaagaua aaagauuugc auucauuagg ucugacucgg gacccaccac aucauuugag      420

agcgccgcuu guccugguug guucuugugc acugcaaugg aggccgauca gccagugagu      480

cucaccaaca ugcccgacga aggcguuaug gugacaaagu uuuauuucca ggaggaugaa      540

uga                                                                    543


<210>  4342
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4342
auggcccugg ccgaccugua cgaggagggc ggcggcggcg gcggcgaggg cgaggacaac       60

gccgacagca aggagaccau cugcagaccc agcggcagaa agagcagcaa gaugcaggcc      120

uucagaaucu gggacgugaa ccagaagacc uucuaccuga gaaacaacca gcugguggcc      180

ggcuaccugc agggccccaa cgugaaccug gaggagaaga ucgacguggu gcccaucgag      240

ccccacgccc uguuccuggg cauccacggc ggcaagaugu gccugagcug cgugaagagc      300

ggcgacgaga ccagacugca gcuggaggcc gugaacauca ccgaccugag cgagaacaga      360

aagcaggaca agagauucgc cuucaucaga agcgacagcg gccccaccac cagcuucgag      420

agcgccgccu gccccggcug guuccugugc accgccaugg aggccgacca gcccgugagc      480

cugaccaaca ugcccgacga gggcgugaug gugaccaagu ucuacuucca ggaggacgag      540

uga                                                                    543


<210>  4343
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4343
auggcccugg cugaccucua cgaggaaggc gggggaggcg ggggagaggg cgaagauaac       60

gccgacagca aggagaccau cugcagaccc uccgggcgga aaucuagcaa gaugcaggcg      120

uuccgcauuu gggaugugaa ucagaaaaca uuuuaucuga gaaacaauca acuugucgcu      180

ggauaccugc agggcccuaa cguuaaucuc gaagagaaga ucgacguggu gccgauugag      240

ccccacgccc uguuccuugg cauccauggg ggaaaaaugu gucuguccug cgucaagucu      300

ggcgaugaaa cgcggcucca gcuggaggcc gugaacauua ccgaccugag cgaaaaucgc      360

aagcaagaua aaagauuugc uuucauccgg uccgacucug ggccuacaac cagcuuugag      420

uccgccgcuu gucccggaug guuccucugc acagccaugg aggcggauca gccuguuagc      480

cugaccaaca ugcccgacga aggcgugaug gucacaaagu uuuauuucca ggaggaugaa      540

uga                                                                    543


<210>  4344
<211>  543
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS2114.1

<400>  4344
auggcacuag cagacuuaua cgaagaagga ggaggaggag gaggagaagg agaagauaau       60

gcagacagca aagaaacaau auguagacca agcggaagaa aaagcucaaa aaugcaagca      120

uucagaauau gggacguaaa ccaaaaaaca uucuaucuaa gaaacaauca auuaguagca      180

ggauauuuac aaggaccaaa cguaaacuua gaagaaaaaa uagacguagu accaauagaa      240

ccacaugcau uauucuuagg aauacacgga ggaaaaaugu gucuaucaug cguaaaauca      300

ggagaugaaa caagauuaca auuagaagca guaaauauaa cagaccuaag ugaaaacaga      360

aaacaagaca aaagauuugc auuuauaaga agcgacagcg gaccaacaac aaguuucgaa      420

agcgcagcau guccaggaug guuucuaugu acagcaaugg aagcagauca accaguauca      480

cuaacaaaca ugccagauga aggaguaaug guaacaaaau uuuacuuuca agaagacgaa      540

uaa                                                                    543


<210>  4345
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__P18510

<400>  4345

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  4346
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4346
auggaaaucu gcagaggccu ccgcagucac cuaaucacuc uccuccucuu ccuguuccau       60

ucagagacga ucugccgacc cucugggaga aaauccagca agaugcaagc cuucagaauc      120

ugggauguua accagaagac cuucuaucug aggaacaacc aacuaguugc uggauacuug      180

caaggaccaa augucaauuu agaagaaaag auagaugugg uacccauuga gccucaugcu      240

cuguucuugg gaauccaugg agggaagaug ugccuguccu gugucaaguc uggugaugag      300

accagacucc agcuggaggc aguuaacauc acugaccuga gcgagaacag aaagcaggac      360

aagcgcuucg ccuucauccg cucagacagu ggccccacca ccaguuuuga gucugccgcc      420

ugccccgguu gguuccucug cacagcgaug gaagcugacc agcccgucag ccucaccaau      480

augccugacg aaggcgucau ggucaccaaa uucuacuucc aggaggacga guag            534


<210>  4347
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4347
auggagaucu gccgcggccu gcggagccac cucaucaccc ugcuccucuu ccuguuccac       60

uccgagacca ucugccgccc cagcgggcgg aaguccagca agaugcaggc cuuccgcauc      120

ugggacguga accagaagac guucuaccug cggaacaacc agcucgucgc cggcuaccug      180

caggggccga acgugaaccu ggaggagaag aucgacgugg uccccaucga gccccacgcg      240

cuguuccugg gcauccacgg gggcaagaug ugccuguccu gcgucaagag cggcgacgag      300

acccgccucc agcuggaggc cgugaacauc accgaccugu ccgagaaccg gaagcaggac      360

aagcgcuucg ccuucauccg gagcgacucc gggcccacca cgagcuucga guccgccgcc      420

ugcccgggcu gguuccucug caccgcgaug gaggccgacc agcccgugag ccugaccaac      480

augcccgacg agggggugau ggugaccaag uucuacuucc aggaggacga guga            534


<210>  4348
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4348
auggagaucu gccgcggccu ccgcucccac cucaucaccc uccuccucuu ccucuuccac       60

uccgagacca ucugccgccc cuccggccgc aaguccucca agaugcaggc cuuccgcauc      120

ugggacguca accagaagac cuucuaccuc cgcaacaacc agcucgucgc cggcuaccuc      180

cagggcccca acgucaaccu cgaggagaag aucgacgucg uccccaucga gccccacgcc      240

cucuuccucg gcauccacgg cggcaagaug ugccucuccu gcgucaaguc cggcgacgag      300

acccgccucc agcucgaggc cgucaacauc accgaccucu ccgagaaccg caagcaggac      360

aagcgcuucg ccuucauccg cuccgacucc ggccccacca ccuccuucga guccgccgcc      420

ugccccggcu gguuccucug caccgccaug gaggccgacc agcccgucuc ccucaccaac      480

augcccgacg agggcgucau ggucaccaag uucuacuucc aggaggacga guga            534


<210>  4349
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4349
auggagaucu gcagaggccu gaggagccac cucauuaccc uucuguuguu cuuauuucau       60

uccgaaacaa uaugucggcc cucugggcgc aagucaagua aaaugcaggc cuuccgaauc      120

ugggacguga accaaaagac uuuuuaccug cguaauaacc agcuagucgc uggauaucuc      180

caggguccua auguuaaccu ggaggagaaa auugaugugg uaccaaucga accgcacgca      240

cuuuuccugg gcauucaugg gggaaagaug ugcuugagcu gugugaaauc cggcgacgaa      300

acgagacucc agcuggaggc cgucaauauc accgaucugu cugagaacag gaagcaagac      360

aagcgguuug cguucauacg cucggauuca ggucccacaa cuagcuuuga aagugcugcc      420

ugcccugggu gguuccucug uaccgcaaug gaggccgacc agccaguguc cuuaacaaau      480

augcccgaug aaggaguuau ggugaccaaa uuuuacuucc aggaggacga guga            534


<210>  4350
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4350
auggagaucu gcagaggccu gagaagccac cugaucaccc ugcugcuguu ccuguuccac       60

agcgagacca ucugcagacc cagcggcaga aagagcagca agaugcaggc cuucagaauc      120

ugggacguga accagaagac cuucuaccug agaaacaacc agcugguggc cggcuaccug      180

cagggcccca acgugaaccu ggaggagaag aucgacgugg ugcccaucga gccccacgcc      240

cuguuccugg gcauccacgg cggcaagaug ugccugagcu gcgugaagag cggcgacgag      300

accagacugc agcuggaggc cgugaacauc accgaccuga gcgagaacag aaagcaggac      360

aagagauucg ccuucaucag aagcgacagc ggccccacca ccagcuucga gagcgccgcc      420

ugccccggcu gguuccugug caccgccaug gaggccgacc agcccgugag ccugaccaac      480

augcccgacg agggcgugau ggugaccaag uucuacuucc aggaggacga guga            534


<210>  4351
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4351
auggagaucu gcagaggccu gcggagccac cucauuaccc ugcuucuguu ccucuuucau       60

uccgaaacaa ucugucgccc cucugggaga aagagcucca aaaugcaggc cuuccggauu      120

ugggacguga accaaaagac guuuuaccug cgcaauaacc agcuugucgc uggauaucug      180

cagggcccua auguuaaccu cgaggagaaa aucgaugugg ugccgauuga accccacgcc      240

cuguuccugg ggauccaugg aggcaagaug ugccucucuu gugucaaaag cggggacgaa      300

accagacugc agcuugaggc ggugaauauc acagaucugu ccgagaaccg gaagcaagac      360

aagcgcuuug cuuucauuag aucugauagc ggaccuacca cauccuuuga aagcgccgcc      420

ugccccggcu gguuccucug uaccgcuaug gaggccgacc agccuguuuc ucugacaaau      480

augcccgaug aaggcgugau ggucaccaaa uuuuacuucc aggaggacga guga            534


<210>  4352
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-1ra_(antagonist)__Homo_sapiens__CCDS46396.1

<400>  4352
auggaaauau gccgaggacu aagaucacac uuaauaacac uacuacuauu ccuauuccac       60

agcgaaacaa uaugcagacc aucaggaaga aaaucaucaa aaaugcaagc auucagaaua      120

ugggacguaa accaaaaaac auucuaccua agaaacaacc aacuaguagc aggauaccua      180

caaggaccaa acguaaaccu agaagaaaaa auagacguag uaccaauaga accacacgca      240

cuauuccuag gaauacacgg aggaaaaaug ugccuaucau gcguaaaauc aggagacgaa      300

acaagacuac aacuagaagc aguaaacaua acagaucuau cagaaaacag aaaacaagac      360

aaaagauucg cauucauaag aucagacuca ggaccaacaa caucauuuga aucagcagca      420

ugcccaggau gguucuuaug cacagccaug gaagcagauc aaccaguauc auuaacaaac      480

augccagacg aaggaguaau gguaacaaaa uucuacuucc aagaagacga auaa            534


<210>  4353
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-20__Homo_sapiens__Q9NYY1

<400>  4353

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     






<210>  4354
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-20__Homo_sapiens__AAH69311

<400>  4354
augaaagccu cuagucuugc cuucagccuu cucucugcug cguuuuaucu ccuauggacu       60

ccuuccacug gacugaagac acucaauuug ggaagcugug ugaucgccac aaaccuucag      120

gaaauacgaa auggauuuuc ugagauacgg ggcagugugc aagccaaaga uggaaacauu      180

gacaucagaa ucuuaaggag gacugagucu uugcaagaca caaagccugc gaaucgaugc      240

ugccuccugc gccauuugcu aagacucuau cuggacaggg uauuuaaaaa cuaccagacc      300

ccugaccauu auacucuccg gaagaucagc agccucgcca auuccuuucu uaccaucaag      360

aaggaccucc ggcucuguca ugcccacaug acaugccauu guggggagga agcaaugaag      420

aaauacagcc agauucugag ucacuuugaa aagcuggaac cucaggcagc aguugugaag      480

gcuuuggggg aacuagacau ucuucugcaa uggauggagg agacagaaua g               531


<210>  4355
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-20__Homo_sapiens__AAH69311

<400>  4355
augaaggcca gcucccuggc cuucagccuc cuguccgcgg ccuucuaccu gcucuggacc       60

cccagcaccg gccugaagac gcugaaccuc ggguccugcg ugaucgccac caaccugcag      120

gagauccgca acggcuucag cgagauccgg ggguccgucc aggccaagga cggcaacauc      180

gacauccgca uccugcggcg caccgagagc cuccaggaca ccaagccggc caaccggugc      240

ugccugcugc gccaccuccu gcggcuguac cucgaccgcg uguucaagaa cuaccagacg      300

cccgaccacu acacccugcg gaagaucucc agccuggcga acuccuuccu caccaucaag      360

aaggaccugc gccugugcca cgcccacaug accugccacu gcggggagga ggccaugaag      420

aaguacagcc agauccucuc ccacuucgag aagcuggagc cccaggccgc gguggucaag      480

gcccugggcg agcucgacau ccugcugcag uggauggagg agacggagug a               531


<210>  4356
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-20__Homo_sapiens__AAH69311

<400>  4356
augaaggccu ccucccucgc cuucucccuc cucuccgccg ccuucuaccu ccucuggacc       60

cccuccaccg gccucaagac ccucaaccuc ggcuccugcg ucaucgccac caaccuccag      120

gagauccgca acggcuucuc cgagauccgc ggcuccgucc aggccaagga cggcaacauc      180

gacauccgca uccuccgccg caccgagucc cuccaggaca ccaagcccgc caaccgcugc      240

ugccuccucc gccaccuccu ccgccucuac cucgaccgcg ucuucaagaa cuaccagacc      300

cccgaccacu acacccuccg caagaucucc ucccucgcca acuccuuccu caccaucaag      360

aaggaccucc gccucugcca cgcccacaug accugccacu gcggcgagga ggccaugaag      420

aaguacuccc agauccucuc ccacuucgag aagcucgagc cccaggccgc cgucgucaag      480

gcccucggcg agcucgacau ccuccuccag uggauggagg agaccgagug a               531


<210>  4357
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-20__Homo_sapiens__AAH69311

<400>  4357
augaaggcca gcucccuggc uuucucucuc cuuucagcag ccuuuuaccu guuguggacc       60

cccaguacag gcuuaaaaac ucugaaccua gggagcugcg ugaucgcgac gaaucuccag      120

gagauuagaa acggauucuc cgaaauaagg gguucugucc aagcuaagga cggcaauauc      180

gauauucgga uccugcgccg aaccgagucg cuucaggaca caaaaccugc caaccguugu      240

ugccuguuga gacaccuccu gaggcuguau cucgaucggg uuuuuaagaa uuaccagacu      300

ccagaccauu auaccuuacg caaaauuuca agccuggcaa acaguuuccu uacaaucaag      360

aaggauuuga gacuguguca cgcccauaug accugccacu guggggaaga ggcuaugaaa      420

aaguacuccc agauacuauc ucauuuugaa aaacucgagc cgcaagcagc cgugguaaag      480

gcucugggag agcuugacau ccuguugcag uggauggaag agacugaaug a               531


<210>  4358
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-20__Homo_sapiens__AAH69311

<400>  4358
augaaggcca gcagccuggc cuucagccug cugagcgccg ccuucuaccu gcuguggacc       60

cccagcaccg gccugaagac ccugaaccug ggcagcugcg ugaucgccac caaccugcag      120

gagaucagaa acggcuucag cgagaucaga ggcagcgugc aggccaagga cggcaacauc      180

gacaucagaa uccugagaag aaccgagagc cugcaggaca ccaagcccgc caacagaugc      240

ugccugcuga gacaccugcu gagacuguac cuggacagag uguucaagaa cuaccagacc      300

cccgaccacu acacccugag aaagaucagc agccuggcca acagcuuccu gaccaucaag      360

aaggaccuga gacugugcca cgcccacaug accugccacu gcggcgagga ggccaugaag      420

aaguacagcc agauccugag ccacuucgag aagcuggagc cccaggccgc cguggugaag      480

gcccugggcg agcuggacau ccugcugcag uggauggagg agaccgagug a               531


<210>  4359
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-20__Homo_sapiens__AAH69311

<400>  4359
augaaggcca gcucccuggc uuucucucuc cugagcgccg cguuuuaccu ucuguggacc       60

cccuccacag gccucaaaac gcugaaccuu gggucuugcg ugaucgcuac caaucugcag      120

gagauuagaa acggauucag cgaaauccgg ggcuccgucc aagccaagga cgggaauauu      180

gauauccgca uucucagacg gacagagucu cugcaggaca ccaaaccugc caaccgcugu      240

ugccugcuca gacaucugcu ucggcuguau cucgaucgcg uuuuuaagaa uuaccagaca      300

ccggaccacu auacccugag aaaaaucagc ucccuugcua acagcuuccu gacaaucaag      360

aaggaucucc ggcuguguca cgcccauaug accugccacu guggagaaga ggcuaugaaa      420

aaguacucuc agauucuguc ccauuuugaa aaacucgagc cccaagccgc gguggugaag      480

gcccugggcg agcuugacau ccugcuccag uggauggaag agacggaaug a               531


<210>  4360
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-20__Homo_sapiens__AAH69311

<400>  4360
augaaagcau caucacuagc auucucauua uuaucagcag cauucuaccu acuauggaca       60

ccaucaacag gacuaaaaac acuaaacuua ggaucaugcg uaauagcaac aaaccuacaa      120

gaaauaagaa acggauucuc agaaauaaga ggaucaguac aagcaaaaga cggaaacaua      180

gacauaagaa uacuaagaag aacagaauca cuacaagaca caaaaccagc aaacagaugc      240

ugccuacuaa gacaccuacu aagacuauau cuagacagag uauucaaaaa cuaccaaaca      300

ccagaccacu acacacuaag aaaaauaucc ucacuagcaa acucauuccu aacaauaaaa      360

aaagaccuaa gacuaugcca cgcccacaug acaugccacu gcggagaaga agcaaugaaa      420

aaauacucac aaauacuauc acacuucgaa aaacuagaac cacaagccgc aguaguaaaa      480

gcacuaggag aacuagacau acuacuacaa uggauggaag aaacagaaua a               531


<210>  4361
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-21__Homo_sapiens__NP_001193935.1

<400>  4361

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Val Ser Thr Leu Ser Phe Ile 
145                 150             


<210>  4362
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-21__Homo_sapiens__CCDS75189.1

<400>  4362
augagaucca guccuggcaa cauggagagg auugucaucu gucugauggu caucuucuug       60

gggacacugg uccacaaauc aagcucccaa ggucaagauc gccacaugau uagaaugcgu      120

caacuuauag auauuguuga ucagcugaaa aauuauguga augacuuggu cccugaauuu      180

cugccagcuc cagaagaugu agagacaaac ugugaguggu cagcuuuuuc cugcuuucag      240

aaggcccaac uaaagucagc aaauacagga aacaaugaaa ggauaaucaa uguaucaauu      300

aaaaagcuga agaggaaacc accuuccaca aaugcaggga gaagacagaa acacagacua      360

acaugcccuu caugugauuc uuaugagaaa aaaccaccca aagaauuccu agaaagauuc      420

aaaucacuuc uccaaaaggu aucuaccuua aguuucauuu ga                         462


<210>  4363
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4363
augcgcagcu cccccggcaa cauggagcgg aucgugaucu gccugauggu caucuuccuc       60

gggacccugg ugcacaagag cuccagccag ggccaggacc gccacaugau ccggaugcgc      120

cagcugaucg acaucgugga ccagcucaag aacuacguca acgaccuggu gcccgaguuc      180

cugcccgccc ccgaggacgu ggagaccaac ugcgaguggu ccgccuucag cugcuuccag      240

aaggcgcagc ucaaguccgc caacacgggg aacaacgagc ggaucaucaa cgucagcauc      300

aagaagcuga agcgcaagcc cccguccacc aacgccggcc ggcgccagaa gcaccggcug      360

accugcccca gcugcgacuc cuacgagaag aagccgccca aggaguuccu cgagcgcuuc      420

aagagccugc ugcagaaggu guccacccuc agcuucaucu ga                         462


<210>  4364
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4364
augcgcuccu cccccggcaa cauggagcgc aucgucaucu gccucauggu caucuuccuc       60

ggcacccucg uccacaaguc cuccucccag ggccaggacc gccacaugau ccgcaugcgc      120

cagcucaucg acaucgucga ccagcucaag aacuacguca acgaccucgu ccccgaguuc      180

cuccccgccc ccgaggacgu cgagaccaac ugcgaguggu ccgccuucuc cugcuuccag      240

aaggcccagc ucaaguccgc caacaccggc aacaacgagc gcaucaucaa cgucuccauc      300

aagaagcuca agcgcaagcc ccccuccacc aacgccggcc gccgccagaa gcaccgccuc      360

accugccccu ccugcgacuc cuacgagaag aagcccccca aggaguuccu cgagcgcuuc      420

aagucccucc uccagaaggu cuccacccuc uccuucaucu ga                         462


<210>  4365
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4365
augagaagcu cccccggcaa cauggagagg aucgugauuu gccugauggu cauauuccuc       60

gggacccuug uucacaaguc uucaagucag ggacaagacc ggcauaugau ccgcaugcga      120

cagcugauug auaucgugga ccaguugaaa aauuacguaa acgauuuagu gccugaauuu      180

cugccagccc cggaggacgu cgaaacaaau ugugagugga gcgcuuucuc cugcuuucag      240

aaggcacaac uaaaaucugc caacacuggu aauaacgaac guauuaucaa ugugucgaua      300

aagaaacuca agagaaagcc cccuucaacg aacgcgggca ggcggcagaa acaccgccug      360

accuguccaa gcugcgauag uuaugagaag aaacccccua aggaguuccu ugaaagauuu      420

aaaucccugu ugcagaaggu uucuacacuc agcuucaucu ga                         462


<210>  4366
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4366
augagaagca gccccggcaa cauggagaga aucgugaucu gccugauggu gaucuuccug       60

ggcacccugg ugcacaagag cagcagccag ggccaggaca gacacaugau cagaaugaga      120

cagcugaucg acaucgugga ccagcugaag aacuacguga acgaccuggu gcccgaguuc      180

cugcccgccc ccgaggacgu ggagaccaac ugcgagugga gcgccuucag cugcuuccag      240

aaggcccagc ugaagagcgc caacaccggc aacaacgaga gaaucaucaa cgugagcauc      300

aagaagcuga agagaaagcc ccccagcacc aacgccggca gaagacagaa gcacagacug      360

accugcccca gcugcgacag cuacgagaag aagcccccca aggaguuccu ggagagauuc      420

aagagccugc ugcagaaggu gagcacccug agcuucaucu ga                         462


<210>  4367
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4367
augagaagcu cccccggcaa cauggagcgg aucgugauuu gccugauggu caucuuccuc       60

gggacccugg uucacaaguc uagcucccag ggacaagacc gccauaugau uagaaugcgg      120

cagcuuaucg auauugugga ccagcugaaa aauuacguga acgaucucgu cccugaauuu      180

cugccggccc ccgaggacgu ggaaacaaau ugugaguggu cugcuuucag cugcuuucag      240

aaggcccaac uuaaauccgc gaacacgggc aauaacgaac gcaucaucaa uguuucuauu      300

aagaaacuga agagaaagcc ucccagcacc aacgcugggc ggcgccagaa acacagacuc      360

acauguccuu ccugcgauag cuaugagaag aaacccccua aggaguuccu ggaacgguuu      420

aaaucucugc uccagaaggu guccacccug agcuucaucu ga                         462


<210>  4368
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-21__Homo_sapiens__CCDS75189.1

<400>  4368
augagaucaa gcccaggaaa cauggaaaga auaguaauau gcuuaauggu aauauuccua       60

ggaacacuag uacacaaauc aucaucacaa ggacaagaca gacacaugau aagaaugaga      120

caacuaauag acauaguaga ccaacuaaaa aacuacguaa acgaccuagu accagaauuc      180

cuaccagcac cagaagacgu agaaacaaac ugcgaauggu cagcauucuc augcuuccaa      240

aaagcacaac uaaaaagcgc aaacacagga aacaacgaaa gaauaauaaa cguaucaaua      300

aaaaaacuaa aaagaaaacc accaucaaca aacgcaggaa gaagacaaaa acacagacua      360

acaugcccaa gcugcgacuc auacgaaaaa aaaccaccaa aagaauucuu agaaagauuc      420

aaaagccuac uacaaaaagu aagcacacua ucauucauau aa                         462


<210>  4369
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-21__Homo_sapiens__NP_068575.1

<400>  4369

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  4370
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-21__Homo_sapiens__CCDS3727.1

<400>  4370
augagaucca guccuggcaa cauggagagg auugucaucu gucugauggu caucuucuug       60

gggacacugg uccacaaauc aagcucccaa ggucaagauc gccacaugau uagaaugcgu      120

caacuuauag auauuguuga ucagcugaaa aauuauguga augacuuggu cccugaauuu      180

cugccagcuc cagaagaugu agagacaaac ugugaguggu cagcuuuuuc cugcuuucag      240

aaggcccaac uaaagucagc aaauacagga aacaaugaaa ggauaaucaa uguaucaauu      300

aaaaagcuga agaggaaacc accuuccaca aaugcaggga gaagacagaa acacagacua      360

acaugcccuu caugugauuc uuaugagaaa aaaccaccca aagaauuccu agaaagauuc      420

aaaucacuuc uccaaaagau gauucaucag caucuguccu cuagaacaca cggaagugaa      480

gauuccuga                                                              489


<210>  4371
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4371
augcgcagcu cccccggcaa cauggagcgg aucgugaucu gccugauggu caucuuccuc       60

gggacccugg ugcacaagag cuccagccag ggccaggacc gccacaugau ccggaugcgc      120

cagcugaucg acaucgugga ccagcucaag aacuacguca acgaccuggu gcccgaguuc      180

cugcccgccc ccgaggacgu ggagaccaac ugcgaguggu ccgccuucag cugcuuccag      240

aaggcgcagc ucaaguccgc caacacgggg aacaacgagc ggaucaucaa cgucagcauc      300

aagaagcuga agcgcaagcc cccguccacc aacgccggcc ggcgccagaa gcaccggcug      360

accugcccca gcugcgacuc cuacgagaag aagccgccca aggaguuccu cgagcgcuuc      420

aagagccugc ugcagaagau gauccaccag caccucucca gccggaccca cggguccgag      480

gacagcuga                                                              489


<210>  4372
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4372
augcgcuccu cccccggcaa cauggagcgc aucgucaucu gccucauggu caucuuccuc       60

ggcacccucg uccacaaguc cuccucccag ggccaggacc gccacaugau ccgcaugcgc      120

cagcucaucg acaucgucga ccagcucaag aacuacguca acgaccucgu ccccgaguuc      180

cuccccgccc ccgaggacgu cgagaccaac ugcgaguggu ccgccuucuc cugcuuccag      240

aaggcccagc ucaaguccgc caacaccggc aacaacgagc gcaucaucaa cgucuccauc      300

aagaagcuca agcgcaagcc ccccuccacc aacgccggcc gccgccagaa gcaccgccuc      360

accugccccu ccugcgacuc cuacgagaag aagcccccca aggaguuccu cgagcgcuuc      420

aagucccucc uccagaagau gauccaccag caccucuccu cccgcaccca cggcuccgag      480

gacuccuga                                                              489


<210>  4373
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4373
augagaagcu cccccggcaa cauggagagg aucgugauuu gccugauggu cauauuccuc       60

gggacccuug uucacaaguc uucaagucag ggacaagacc ggcauaugau ccgcaugcga      120

cagcugauug auaucgugga ccaguugaaa aauuacguaa acgauuuagu gccugaauuu      180

cugccagccc cggaggacgu cgaaacaaau ugugagugga gcgcuuucuc cugcuuucag      240

aaggcacaac uaaaaucugc caacacuggu aauaacgaac guauuaucaa ugugucgaua      300

aagaaacuca agagaaagcc cccuucaacg aacgcgggca ggcggcagaa acaccgccug      360

accuguccaa gcugcgauag uuaugagaag aaacccccua aggaguuccu ugaaagauuu      420

aaaucccugu ugcagaagau gauccaucag caccucucua gcaggacaca uggguccgag      480

gacucauga                                                              489


<210>  4374
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4374
augagaagca gccccggcaa cauggagaga aucgugaucu gccugauggu gaucuuccug       60

ggcacccugg ugcacaagag cagcagccag ggccaggaca gacacaugau cagaaugaga      120

cagcugaucg acaucgugga ccagcugaag aacuacguga acgaccuggu gcccgaguuc      180

cugcccgccc ccgaggacgu ggagaccaac ugcgagugga gcgccuucag cugcuuccag      240

aaggcccagc ugaagagcgc caacaccggc aacaacgaga gaaucaucaa cgugagcauc      300

aagaagcuga agagaaagcc ccccagcacc aacgccggca gaagacagaa gcacagacug      360

accugcccca gcugcgacag cuacgagaag aagcccccca aggaguuccu ggagagauuc      420

aagagccugc ugcagaagau gauccaccag caccugagca gcagaaccca cggcagcgag      480

gacagcuga                                                              489


<210>  4375
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4375
augagaagcu cccccggcaa cauggagcgg aucgugauuu gccugauggu caucuuccuc       60

gggacccugg uucacaaguc uagcucccag ggacaagacc gccauaugau uagaaugcgg      120

cagcuuaucg auauugugga ccagcugaaa aauuacguga acgaucucgu cccugaauuu      180

cugccggccc ccgaggacgu ggaaacaaau ugugaguggu cugcuuucag cugcuuucag      240

aaggcccaac uuaaauccgc gaacacgggc aauaacgaac gcaucaucaa uguuucuauu      300

aagaaacuga agagaaagcc ucccagcacc aacgcugggc ggcgccagaa acacagacuc      360

acauguccuu ccugcgauag cuaugagaag aaacccccua aggaguuccu ggaacgguuu      420

aaaucucugc uccagaagau gauccaucag caccugucca gccgcaccca uggaucugag      480

gacuccuga                                                              489


<210>  4376
<211>  489
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-21__Homo_sapiens__CCDS3727.1

<400>  4376
augagaucau caccaggaaa cauggaaaga auaguaauau gccuaauggu aauauuccuc       60

ggaacacuag uacacaaauc aucaucacaa ggacaagaca gacacaugau aagaaugaga      120

caacuaauag acauaguaga ccaacuaaaa aacuacguaa acgaccuagu accagaauuc      180

cuaccagcac cagaagacgu agaaacaaac ugcgaauggu cagcauucuc augcuuccaa      240

aaagcacaac uaaaaucagc aaacacagga aacaacgaaa gaauaauaaa cguaucaaua      300

aaaaaauuaa aaagaaaacc accaucaaca aacgcaggac gaagacaaaa acacagacuc      360

acaugcccau caugcgacuc auacgaaaaa aaaccaccaa aagaauuccu agaaagauuc      420

aaaucacuac uacaaaaaau gauacaccaa caccuaucau caagaacaca cggaucagaa      480

gacagcuaa                                                              489


<210>  4377
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-22__Homo_sapiens__Q9GZX6

<400>  4377

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  4378
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-22__Homo_sapiens__AAG22064

<400>  4378
auggccgccc ugcagaaauc ugugagcucu uuccuuaugg ggacccuggc caccagcugc       60

cuccuucucu uggcccucuu gguacaggga ggagcagcug cgcccaucag cucccacugc      120

aggcuugaca aguccaacuu ccagcagccc uauaucacca accgcaccuu caugcuggcu      180

aaggaggcua gcuuggcuga uaacaacaca gacguucguc ucauugggga gaaacuguuc      240

cacggaguca guaugaguga gcgcugcuau cugaugaagc aggugcugaa cuucacccuu      300

gaagaagugc uguucccuca aucugauagg uuccagccuu auaugcagga gguggugccc      360

uuccuggcca ggcucagcaa caggcuaagc acaugucaua uugaagguga ugaccugcau      420

auccagagga augugcaaaa gcugaaggac acagugaaaa agcuuggaga gaguggagag      480

aucaaagcaa uuggagaacu ggauuugcug uuuaugucuc ugagaaaugc cugcauuuga      540


<210>  4379
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-22__Homo_sapiens__AAG22064

<400>  4379
auggccgccc ugcagaaguc cgugagcagc uuccucaugg gcacccuggc gaccuccugc       60

cugcuccugc uggcccuccu gguccagggc ggggccgccg cccccaucag cucccacugc      120

cgccuggaca agagcaacuu ccagcagccg uacaucacga accggaccuu caugcucgcg      180

aaggaggccu cccuggccga caacaacacc gacgugcgcc ugaucgggga gaagcuguuc      240

cacggcguga gcauguccga gcggugcuac cucaugaagc agguccugaa cuucacccuc      300

gaggaggugc uguuccccca gagcgaccgc uuccagcccu acaugcagga gguggucccc      360

uuccuggccc ggcucuccaa ccgccugagc acgugccaca ucgaggggga cgaccugcac      420

auccagcgga acgugcagaa gcucaaggac accgugaaga agcugggcga guccggcgag      480

aucaaggcga ucggggagcu ggaccuccug uucaugagcc ugcgcaacgc cugcaucuga      540


<210>  4380
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-22__Homo_sapiens__AAG22064

<400>  4380
auggccgccc uccagaaguc cgucuccucc uuccucaugg gcacccucgc caccuccugc       60

cuccuccucc ucgcccuccu cguccagggc ggcgccgccg cccccaucuc cucccacugc      120

cgccucgaca aguccaacuu ccagcagccc uacaucacca accgcaccuu caugcucgcc      180

aaggaggccu cccucgccga caacaacacc gacguccgcc ucaucggcga gaagcucuuc      240

cacggcgucu ccauguccga gcgcugcuac cucaugaagc agguccucaa cuucacccuc      300

gaggaggucc ucuuccccca guccgaccgc uuccagcccu acaugcagga ggucgucccc      360

uuccucgccc gccucuccaa ccgccucucc accugccaca ucgagggcga cgaccuccac      420

auccagcgca acguccagaa gcucaaggac accgucaaga agcucggcga guccggcgag      480

aucaaggcca ucggcgagcu cgaccuccuc uucauguccc uccgcaacgc cugcaucuga      540


<210>  4381
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-22__Homo_sapiens__AAG22064

<400>  4381
auggccgcuc ugcagaaaag cguguccucu uuccucaugg gcacccuugc aacaucaugc       60

cuguuguuac uggcccuacu cguccaaggg ggagcggcug cccccaucag uagccacugu      120

agacuggaca aguccaacuu ucagcagccu uacauuacua auaggacguu caugcuugca      180

aaggaggccu cucuggcuga uaacaauacc gacguucggu ugauagguga aaaacucuuu      240

cauggcgugu cgaugucaga gcgcugcuau cugaugaagc agguacugaa cuucacacuc      300

gaagaggugu uauuuccaca aagcgaucga uuccagccgu acaugcagga agucgugccc      360

uuucuggcac gucuuaguaa uagauugucc acuugucaca ucgaggggga cgaucugcau      420

auucagagga acguucaaaa acuaaaggac accgugaaga aacucggaga gucuggcgaa      480

aucaaggcca uuggugagcu ggaucuucug uucaugagcu ugcggaaugc uugcaucuga      540


<210>  4382
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-22__Homo_sapiens__AAG22064

<400>  4382
auggccgccc ugcagaagag cgugagcagc uuccugaugg gcacccuggc caccagcugc       60

cugcugcugc uggcccugcu ggugcagggc ggcgccgccg cccccaucag cagccacugc      120

agacuggaca agagcaacuu ccagcagccc uacaucacca acagaaccuu caugcuggcc      180

aaggaggcca gccuggccga caacaacacc gacgugagac ugaucggcga gaagcuguuc      240

cacggcguga gcaugagcga gagaugcuac cugaugaagc aggugcugaa cuucacccug      300

gaggaggugc uguuccccca gagcgacaga uuccagcccu acaugcagga gguggugccc      360

uuccuggcca gacugagcaa cagacugagc accugccaca ucgagggcga cgaccugcac      420

auccagagaa acgugcagaa gcugaaggac accgugaaga agcugggcga gagcggcgag      480

aucaaggcca ucggcgagcu ggaccugcug uucaugagcc ugagaaacgc cugcaucuga      540


<210>  4383
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-22__Homo_sapiens__AAG22064

<400>  4383
auggccgcuc ugcagaaaag cguguccucu uuccucaugg gcacccuggc cacaagcugc       60

cuucugcucc uggcgcuucu gguccaaggg ggagcugccg cccccaucuc cucucacugu      120

agacucgaca agagcaacuu ucagcagccu uacauuacga aucggaccuu caugcuggcu      180

aaggaggccu cccuggcuga uaacaauaca gacguucgcc ucaucggcga aaaacuguuu      240

cauggggugu cuaugagcga gagaugcuau cuuaugaaac aggugcugaa cuucacccuc      300

gaagaggucc uguuuccgca auccgaucgg uuccagcccu acaugcagga agugguuccu      360

uuucuugccc gccugagcaa uagacucucu acaugucaca uugagggaga cgaucugcau      420

auccagcgga acgugcaaaa gcugaaggac accgucaaga aacucggcga guccggggaa      480

auuaaggcga ucggagagcu ggaucuucug uucaugagcc uccgcaaugc cugcaucuga      540


<210>  4384
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-22__Homo_sapiens__AAG22064

<400>  4384
auggcagcac uacaaaaauc aguaucauca uuccuaaugg gaacacuagc aacaucaugc       60

cuacuacuac uagcacuacu aguacaagga ggagcagcag caccaauauc aucacacugc      120

agauuagaca aaucaaacuu ccaacaacca uacauaacaa acagaacauu caugcuagca      180

aaagaagcau cacuagcaga caacaacaca gacguaagau uaauaggaga aaaacuuuuc      240

cacggaguau caaugucaga aagaugcuac cuaaugaaac aaguacuaaa cuucacauua      300

gaagaaguac uauucccaca aagcgacaga uuccaaccau acaugcaaga aguaguacca      360

uuccuagcaa gacuaucaaa cagacuaucc acaugccaca uagaaggaga cgaccuacac      420

auacaaagaa acguacaaaa acuaaaagac acaguaaaaa aacuaggaga aucaggagaa      480

auaaaagcaa uaggagaacu agaccuacua uucaugucac uaagaaacgc augcauauaa      540


<210>  4385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-23__Homo_sapiens__Q9NPF7

<400>  4385

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  4386
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-23__Homo_sapiens__AAH66268

<400>  4386
augcugggga gcagagcugu aaugcugcug uugcuacugc ccuggacagc ucagggcaga       60

gcugugccug ggggcagcag cccugccugg acucagugcc agcagcuuuc acagaagcuc      120

ugcacacugg ccuggagugc acauccacua gugggacaca uggaucuaag agaagaggga      180

gaugaagaga cuacaaauga uguuccccau auccagugug gagauggcug ugacccccaa      240

ggacucaggg acaacaguca guucugcuug caaaggaucc accagggucu gauuuuuuau      300

gagaagcugc uaggaucgga uauuuucaca ggggagccuu cucugcuccc ugauagcccu      360

gugggccagc uucaugccuc ccuacugggc cucagccaac uccugcagcc ugagggucac      420

cacugggaga cucagcagau uccaagccuc agucccagcc agccauggca gcgucuccuu      480

cuccgcuuca agauccuucg cagccuccag gccuuugugg ccguagccgc ccgggucuuu      540

gcccauggag cagcaacccu gagucccuaa                                       570


<210>  4387
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-23__Homo_sapiens__AAH66268

<400>  4387
augcugggca gccgcgccgu gaugcuccug cugcuccugc ccuggaccgc ccaggggcgg       60

gcggucccgg gcggguccag ccccgccugg acccagugcc agcagcuguc ccagaagcuc      120

ugcacgcugg ccuggagcgc ccacccccug gugggccaca uggaccuccg cgaggagggg      180

gacgaggaga ccaccaacga cgugccccac auccagugcg gcgacggcug cgacccgcag      240

gggcugcggg acaacuccca guucugccug cagcgcaucc accagggccu caucuucuac      300

gagaagcugc uggggagcga caucuucacc ggcgagcccu cccuccugcc cgacagcccc      360

gucgggcagc ugcacgccuc ccuccugggc cugagccagc uccugcagcc ggagggccac      420

cacugggaga cgcagcagau ccccucccug agccccuccc agcccuggca gcggcuccug      480

cugcgcuuca agauccuccg gagccugcag gcguucgugg ccguggccgc ccgcgucuuc      540

gcgcacgggg ccgccacccu guccccguga                                       570


<210>  4388
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-23__Homo_sapiens__AAH66268

<400>  4388
augcucggcu cccgcgccgu caugcuccuc cuccuccucc ccuggaccgc ccagggccgc       60

gccguccccg gcggcuccuc ccccgccugg acccagugcc agcagcucuc ccagaagcuc      120

ugcacccucg ccugguccgc ccacccccuc gucggccaca uggaccuccg cgaggagggc      180

gacgaggaga ccaccaacga cgucccccac auccagugcg gcgacggcug cgacccccag      240

ggccuccgcg acaacuccca guucugccuc cagcgcaucc accagggccu caucuucuac      300

gagaagcucc ucggcuccga caucuucacc ggcgagcccu cccuccuccc cgacuccccc      360

gucggccagc uccacgccuc ccuccucggc cucucccagc uccuccagcc cgagggccac      420

cacugggaga cccagcagau ccccucccuc ucccccuccc agcccuggca gcgccuccuc      480

cuccgcuuca agauccuccg cucccuccag gccuucgucg ccgucgccgc ccgcgucuuc      540

gcccacggcg ccgccacccu cucccccuga                                       570


<210>  4389
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-23__Homo_sapiens__AAH66268

<400>  4389
augcugggca gcagagccgu gaugcuccuu cuguuguuac ccuggaccgc ucaggggagg       60

gcagucccug gagguuccuc uccagccugg acacaaugcc agcagcuguc acagaagcua      120

uguacucucg cguggagugc ucacccgcug guuggccaua uggaccuucg ggaggaaggg      180

gaugaggaaa cgaccaacga cgugccccac auccaaugcg gagauggcug ugacccucag      240

ggucugcgcg auaauagcca guucugcuug cagcguauuc aucaagggcu cauauuuuac      300

gagaaacugc ugggauccga caucuucaca ggcgaaccau cucucuuacc cgauucgccu      360

guaggccagc ugcacgccuc acuuuugggg cugagccagc uacuccagcc agagggacau      420

cacugggaga cucaacagau ucccagucug uccccuucuc agccauggca acgacuucug      480

uugagauuua agauccucag gagccugcag gcauucgugg ccgucgcugc acggguguuu      540

gcccacggug cugccaccuu auccccguga                                       570


<210>  4390
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-23__Homo_sapiens__AAH66268

<400>  4390
augcugggca gcagagccgu gaugcugcug cugcugcugc ccuggaccgc ccagggcaga       60

gccgugcccg gcggcagcag ccccgccugg acccagugcc agcagcugag ccagaagcug      120

ugcacccugg ccuggagcgc ccacccccug gugggccaca uggaccugag agaggagggc      180

gacgaggaga ccaccaacga cgugccccac auccagugcg gcgacggcug cgacccccag      240

ggccugagag acaacagcca guucugccug cagagaaucc accagggccu gaucuucuac      300

gagaagcugc ugggcagcga caucuucacc ggcgagccca gccugcugcc cgacagcccc      360

gugggccagc ugcacgccag ccugcugggc cugagccagc ugcugcagcc cgagggccac      420

cacugggaga cccagcagau ccccagccug agccccagcc agcccuggca gagacugcug      480

cugagauuca agauccugag aagccugcag gccuucgugg ccguggccgc cagaguguuc      540

gcccacggcg ccgccacccu gagccccuga                                       570


<210>  4391
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-23__Homo_sapiens__AAH66268

<400>  4391
augcugggca gcagagccgu gaugcuccug cuucugcucc ccuggaccgc ucaggggcgg       60

gccgucccug gaggcuccuc uccggcgugg acacaaugcc agcagcugag ccagaagcug      120

uguacgcuug cuugguccgc ccacccccuc guugggcaua uggaccugcg cgaggaagga      180

gaugaggaaa ccacaaacga cgugccucac auccaaugcg gcgaugggug ugacccccag      240

ggacugagag auaauucuca guucugccuc cagcggauuc aucaaggccu gaucuuuuac      300

gagaaacuuc ugggcagcga cauuuucacc ggggaaccuu cccuccugcc cgauucuccu      360

gugggacagc uucacgccag ccugcucggc cugucccagc ugcuccagcc ggaggggcau      420

cacugggaga cacaacagau ccccagccug ucuccuuccc agcccuggca acgccuucug      480

cucagauuua agauucugcg gagccuucag gcuuucgucg ccguggcugc ccgcguuuuu      540

gcgcacggag ccgcuacccu gucuccuuga                                       570


<210>  4392
<211>  570
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-23__Homo_sapiens__AAH66268

<400>  4392
augcuaggau caagagcagu aaugcuacua uuauuacuac cauggacagc ucaaggaaga       60

gcaguaccag gaggaucauc accagcaugg acacaaugcc aacaacuauc acaaaaauua      120

uguacacuag cauggucagc acacccacua guaggacaca uggacuuaag agaagaagga      180

gacgaagaaa caacaaacga cguaccacac auacaaugcg gagacggaug cgacccacaa      240

ggacuaagag acaacucaca auucugucua caaagaauac accaaggccu aauauucuac      300

gaaaaacuau uaggaucaga cauauucaca ggagaaccau cacuauuacc cgacucacca      360

guaggacaau uacacgcauc acuuuuagga cuaucacaac uacuacaacc agaaggacau      420

cacugggaaa cccaacaaau cccaucauua ucacccucac aaccauggca aagacuacua      480

cuaagauuua aaauacuaag aucacuacaa gcauucguag caguagcagc aagaguauuc      540

gcacacggag cagcaacacu aucaccauaa                                       570


<210>  4393
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-24__Homo_sapiens__Q13007

<400>  4393

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Arg Pro 
1               5                   10                  15      


Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val Val 
            20                  25                  30          


Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser Gly 
        35                  40                  45              


Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
    50                  55                  60                  


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
65                  70                  75                  80  


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
                85                  90                  95      


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
            100                 105                 110         


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
        115                 120                 125             


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
    130                 135                 140                 


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
145                 150                 155                 160 


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
                165                 170                 175     


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
            180                 185                 190         


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205     


<210>  4394
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-24__Homo_sapiens__AAA91780

<400>  4394
augaauuuuc aacagaggcu gcaaagccug uggacuuuag ccagacccuu cugcccuccu       60

uugcuggcga cagccucuca aaugcagaug guugugcucc cuugccuggg uuuuacccug      120

cuucucugga gccagguauc aggggcccag ggccaagaau uccacuuugg gcccugccaa      180

gugaaggggg uuguucccca gaaacugugg gaagccuucu gggcugugaa agacacuaug      240

caagcucagg auaacaucac gagugcccgg cugcugcagc aggagguucu gcagaacguc      300

ucggaugcug agagcuguua ccuuguccac acccugcugg aguucuacuu gaaaacuguu      360

uucaaaaacu accacaauag aacaguugaa gucaggacuc ugaagucauu cucuacucug      420

gccaacaacu uuguucucau cgugucacaa cugcaaccca gucaagaaaa ugagauguuu      480

uccaucagag acagugcaca caggcgguuu cugcuauucc ggagagcauu caaacaguug      540

gacguagaag cagcucugac caaagcccuu ggggaagugg acauucuucu gaccuggaug      600

cagaaauucu acaagcucug a                                                621


<210>  4395
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-24__Homo_sapiens__AAA91780

<400>  4395
augaacuucc agcagcgccu gcagagccuc uggacccugg cccggcccuu cugcccgccc       60

cugcucgcca ccgcguccca gaugcagaug gugguccugc ccugccuggg cuucacgcuc      120

cugcugugga gccagguguc cggggcccag ggccaggagu uccacuucgg gcccugccag      180

gugaagggcg ucgugccgca gaagcucugg gaggccuucu gggccgugaa ggacaccaug      240

caggcccagg acaacaucac cagcgcgcgc cugcugcagc aggagguccu ccagaacgug      300

uccgacgccg agagcugcua ccuggugcac acccugcucg aguucuaccu gaagacgguc      360

uucaagaacu accacaaccg gaccguggag gugcgcaccc ugaaguccuu cagcacccuc      420

gccaacaacu ucguccugau cgugucccag cugcagccca gccaggagaa cgagauguuc      480

uccauccggg acagcgccca ccgccgguuc cuccuguucc gccgggcguu caagcagcug      540

gacguggagg ccgcccucac gaaggcccug ggggaggucg acauccugcu caccuggaug      600

cagaaguucu acaagcugug a                                                621


<210>  4396
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-24__Homo_sapiens__AAA91780

<400>  4396
augaacuucc agcagcgccu ccagucccuc uggacccucg cccgccccuu cugccccccc       60

cuccucgcca ccgccuccca gaugcagaug gucguccucc ccugccucgg cuucacccuc      120

cuccucuggu cccaggucuc cggcgcccag ggccaggagu uccacuucgg ccccugccag      180

gucaagggcg ucguccccca gaagcucugg gaggccuucu gggccgucaa ggacaccaug      240

caggcccagg acaacaucac cuccgcccgc cuccuccagc aggagguccu ccagaacguc      300

uccgacgccg aguccugcua ccucguccac acccuccucg aguucuaccu caagaccguc      360

uucaagaacu accacaaccg caccgucgag guccgcaccc ucaaguccuu cuccacccuc      420

gccaacaacu ucguccucau cgucucccag cuccagcccu cccaggagaa cgagauguuc      480

uccauccgcg acuccgccca ccgccgcuuc cuccucuucc gccgcgccuu caagcagcuc      540

gacgucgagg ccgcccucac caaggcccuc ggcgaggucg acauccuccu caccuggaug      600

cagaaguucu acaagcucug a                                                621


<210>  4397
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-24__Homo_sapiens__AAA91780

<400>  4397
augaacuucc agcaaagacu gcagagccuc uggacccuug ccaggcccuu uugcccucca       60

cuguuggcua cagcauccca gaugcagaug guggucuuac cgugucuggg cuucacucua      120

cuccuguggu cucaaguuuc aggggcccag ggacaggagu uucacuucgg ucccugccag      180

gugaagggcg uagugccuca aaaacuuugg gaagcguuuu gggcugucaa ggacacgaug      240

caggcccagg auaauaucac cagugcacgg cuguugcagc aagaggugcu ccagaacguu      300

agcgacgccg aauccuguua ccuggugcau acacugcucg aguucuauuu aaaaacuguc      360

uuuaagaauu accacaaccg caccguggaa guacgaacac ugaaaucuuu cucgacccuu      420

gcuaauaacu uuguuuugau ugugucacag cugcaaccaa gccaggagaa ugagauguuc      480

aguauacgug auuccgcaca uagaagguuu cuacucuucc ggcgcgccuu uaagcagcug      540

gacgucgaag cugcccuuac uaaggcgcug ggggaggugg auaucuugcu cacauggaug      600

cagaaauucu auaagcugug a                                                621


<210>  4398
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-24__Homo_sapiens__AAA91780

<400>  4398
augaacuucc agcagagacu gcagagccug uggacccugg ccagacccuu cugccccccc       60

cugcuggcca ccgccagcca gaugcagaug guggugcugc ccugccuggg cuucacccug      120

cugcugugga gccaggugag cggcgcccag ggccaggagu uccacuucgg ccccugccag      180

gugaagggcg uggugcccca gaagcugugg gaggccuucu gggccgugaa ggacaccaug      240

caggcccagg acaacaucac cagcgccaga cugcugcagc aggaggugcu gcagaacgug      300

agcgacgccg agagcugcua ccuggugcac acccugcugg aguucuaccu gaagaccgug      360

uucaagaacu accacaacag aaccguggag gugagaaccc ugaagagcuu cagcacccug      420

gccaacaacu ucgugcugau cgugagccag cugcagccca gccaggagaa cgagauguuc      480

agcaucagag acagcgccca cagaagauuc cugcuguuca gaagagccuu caagcagcug      540

gacguggagg ccgcccugac caaggcccug ggcgaggugg acauccugcu gaccuggaug      600

cagaaguucu acaagcugug a                                                621


<210>  4399
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-24__Homo_sapiens__AAA91780

<400>  4399
augaacuucc agcaaagacu gcagagccuc uggacccugg cccggcccuu uugcccuccg       60

cuucuggcua cagccuccca gaugcagaug gugguccucc ccugucuggg cuucacgcuu      120

cugcucuggu cucaaguuag cggggcgcag ggacaggagu uucacuucgg cccuugccag      180

gugaaggggg ugguccccca aaaacugugg gaggcuuuuu gggccgugaa ggacaccaug      240

caggcccagg auaauaucac auccgcucgc cugcuccagc aagaaguucu gcagaacgug      300

ucugacgccg aaagcuguua ccuuguccau acccugcucg aguucuaucu gaaaacagug      360

uuuaagaauu accacaacag aaccguugaa gugcggacac uuaaauccuu cucuacccug      420

gcuaauaacu uuguccucau ugugagccag cugcaaccuu cccaggagaa ugagauguuc      480

agcauccgcg auucugccca uagacgguuu cuucucuucc gcagagcguu uaagcagcug      540

gacguggaag ccgcucuuac gaaggcccug ggagaggucg auauucuccu gaccuggaug      600

cagaaauucu auaagcugug a                                                621


<210>  4400
<211>  621
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-24__Homo_sapiens__AAA91780

<400>  4400
augaacuucc aacaaagacu acaaucacua uggacauuag caagaccauu cugcccacca       60

cuacuagcaa cagcaucaca aaugcaaaug guaguacucc caugccuagg auucacauua      120

cuauuauggu cacaaguauc cggagcccaa ggacaagaau uccacuucgg accaugccaa      180

guaaaaggag uaguaccaca aaaacuaugg gaagcauucu gggcaguaaa agauacaaug      240

caagcacaag acaacauaac aucagccaga cuacuacaac aagaaguacu acaaaacgua      300

ucagacgcag aaucaugcua ccuaguacac acacuccuag aauucuaccu aaaaacagua      360

uucaaaaacu aucacaacag aacaguagaa guaagaacac uaaaaucauu cucaacacua      420

gcaaacaacu ucguauuaau aguuucacaa cuacaaccau cccaagaaaa cgaaauguuc      480

ucaauaagag auuccgcaca cagaagauuc cuacuauuca gaagagcauu caaacaacua      540

gacgucgaag cagcacuaac aaaagcacua ggagaaguag acauacuacu aacauggaug      600

caaaaauucu acaaauuaua a                                                621


<210>  4401
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-24__Homo_sapiens__Q2YHE6

<400>  4401

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Lys 
1               5                   10                  15      


Leu Arg Ile Thr Ser Arg Val Pro Gly Cys Cys Asn Arg Arg Phe Cys 
            20                  25                  30          


Arg Thr Ser Arg Met Leu Arg Ala Val Thr Leu Ser Thr Pro Cys Trp 
        35                  40                  45              


Ser Ser Thr 
    50      


<210>  4402
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-24__Homo_sapiens__AAV52800

<400>  4402
augaauuuuc aacagaggcu gcaaagccug uggacuuuag ccagcaagcu caggauaaca       60

ucacgagugc ccggcugcug caacaggagg uucugcagaa cgucucggau gcugagggcu      120

guuaccuugu ccacacccug cuggaguucu acuuga                                156


<210>  4403
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-24__Homo_sapiens__AAV52800

<400>  4403
augaacuucc agcagcgccu gcagagccuc uggacccugg ccuccaagcu gcggaucacc       60

agccgcgugc ccggcugcug caaccggcgc uucugccgga cgucccgcau gcuccgggcc      120

gucacccuga gcaccccgug cugguccagc accuga                                156


<210>  4404
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-24__Homo_sapiens__AAV52800

<400>  4404
augaacuucc agcagcgccu ccagucccuc uggacccucg ccuccaagcu ccgcaucacc       60

ucccgcgucc ccggcugcug caaccgccgc uucugccgca ccucccgcau gcuccgcgcc      120

gucacccucu ccacccccug cugguccucc accuga                                156


<210>  4405
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-24__Homo_sapiens__AAV52800

<400>  4405
augaacuucc agcaaagacu gcagagccuc uggacccuug ccuccaagcu gaggaucaca       60

ucucgggugc ccggcugcug uaaucgccga uuuugccgua cuucaagaau guugagggcu      120

gucacguuaa guaccccuug uuggagcucc acauga                                156


<210>  4406
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-24__Homo_sapiens__AAV52800

<400>  4406
augaacuucc agcagagacu gcagagccug uggacccugg ccagcaagcu gagaaucacc       60

agcagagugc ccggcugcug caacagaaga uucugcagaa ccagcagaau gcugagagcc      120

gugacccuga gcacccccug cuggagcagc accuga                                156


<210>  4407
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-24__Homo_sapiens__AAV52800

<400>  4407
augaacuucc agcaaagacu gcagagccuc uggacccugg ccuccaagcu gcggaucaca       60

ucucgcgugc ccggcugcug uaauagacgg uuuugccgca cgagcagaau gcuucgggcu      120

gucacccucu ccacaccuug uuggucuagc accuga                                156


<210>  4408
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-24__Homo_sapiens__AAV52800

<400>  4408
augaacuuuc aacaaagacu acaaucacua uggacauuag caucaaaauu aagaauaaca       60

ucaagaguac caggaugcug uaacagaaga uucugcagaa caucaagaau gcuaagagca      120

guaacauuaa gcacaccaug cuggucaagc acauaa                                156


<210>  4409
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-25__Homo_sapiens__Q969H8

<400>  4409

Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          


Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              


His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  


Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  


Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      


Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         


Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             


Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 


Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 


Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
                165                 170             


<210>  4410
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-25__Homo_sapiens__AAH10129

<400>  4410
auggcggcgc ccagcggagg guggaacggc gucggcgcga gcuugugggc cgcgcugcuc       60

cuaggggccg uggcgcugag gccggcggag gcgguguccg agcccacgac gguggcguuu      120

gacgugcggc ccggcggcgu cgugcauucc uucucccaua acgugggccc gggggacaaa      180

uauacgugua uguucacuua cgccucucaa ggagggacca augagcaaug gcagaugagu      240

cuggggacca gcgaagacca ccagcacuuc accugcacca ucuggaggcc ccaggggaag      300

uccuaucugu acuucacaca guucaaggca gaggugcggg gcgcugagau ugaguacgcc      360

auggccuacu cuaaagccgc auuugaaagg gaaagugaug ucccucugaa aacugaggaa      420

uuugaaguga ccaaaacagc aguggcucac aggcccgggg cauucaaagc ugagcugucc      480

aagcugguga uuguggccaa ggcaucgcgc acugagcugu ga                         522


<210>  4411
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-25__Homo_sapiens__AAH10129

<400>  4411
auggccgccc ccagcggcgg guggaacggc gugggggcgu cccugugggc cgcccuccug       60

cugggcgccg ucgcccuccg cccggcggag gccgugagcg agcccaccac cguggccuuc      120

gacguccggc ccgggggcgu ggugcacucc uucagccaca acgucggccc cggggacaag      180

uacacgugca uguucaccua cgccucccag ggcgggacca acgagcagug gcagaugagc      240

cugggcaccu ccgaggacca ccagcacuuc acgugcacca ucuggcgccc gcaggggaag      300

uccuaccugu acuucaccca guucaaggcg gaggugcggg gcgccgagau cgaguacgcc      360

auggccuaca gcaaggccgc guucgagcgc gagagcgacg ugccccucaa gaccgaggag      420

uucgagguca cgaagaccgc cguggcccac cggcccggcg ccuucaaggc cgagcugucc      480

aagcugguga ucgucgcgaa ggccagccgc accgagcucu ga                         522


<210>  4412
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-25__Homo_sapiens__AAH10129

<400>  4412
auggccgccc ccuccggcgg cuggaacggc gucggcgccu cccucugggc cgcccuccuc       60

cucggcgccg ucgcccuccg ccccgccgag gccgucuccg agcccaccac cgucgccuuc      120

gacguccgcc ccggcggcgu cguccacucc uucucccaca acgucggccc cggcgacaag      180

uacaccugca uguucaccua cgccucccag ggcggcacca acgagcagug gcagaugucc      240

cucggcaccu ccgaggacca ccagcacuuc accugcacca ucuggcgccc ccagggcaag      300

uccuaccucu acuucaccca guucaaggcc gagguccgcg gcgccgagau cgaguacgcc      360

auggccuacu ccaaggccgc cuucgagcgc gaguccgacg ucccccucaa gaccgaggag      420

uucgagguca ccaagaccgc cgucgcccac cgccccggcg ccuucaaggc cgagcucucc      480

aagcucguca ucgucgccaa ggccucccgc accgagcucu ga                         522


<210>  4413
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-25__Homo_sapiens__AAH10129

<400>  4413
auggccgcuc ccagcggcgg guggaacgga gugggugcau cccugugggc cgcgcuccuu       60

cugggcgcug ucgccuugag accugcagag gccguuucug aaccaaccac aguggcuuuc      120

gacguaaggc ccgggggagu gguccacuca uuuagucaua augugggccc gggugauaag      180

uacacuugca uguucacgua ugcaagccaa gggggaacca acgagcagug gcagaugucc      240

uuaggcacau cugaagacca ccagcauuuu acuuguacca ucuggcggcc ucagggcaaa      300

ucguaccugu auuucacaca auuuaaggcc gagguucgcg gggcugaaau ugaguacgcc      360

auggcguauu caaaagcagc cuucgagcga gaaagcgaug ugccacuaaa gaccgaggaa      420

uuugagguca cuaaaacagc uguggcccac cgucccggag cauucaaggc ugagcucagu      480

aagcugguaa uaguugccaa agcguccaga accgaacuuu ga                         522


<210>  4414
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-25__Homo_sapiens__AAH10129

<400>  4414
auggccgccc ccagcggcgg cuggaacggc gugggcgcca gccugugggc cgcccugcug       60

cugggcgccg uggcccugag acccgccgag gccgugagcg agcccaccac cguggccuuc      120

gacgugagac ccggcggcgu ggugcacagc uucagccaca acgugggccc cggcgacaag      180

uacaccugca uguucaccua cgccagccag ggcggcacca acgagcagug gcagaugagc      240

cugggcacca gcgaggacca ccagcacuuc accugcacca ucuggagacc ccagggcaag      300

agcuaccugu acuucaccca guucaaggcc gaggugagag gcgccgagau cgaguacgcc      360

auggccuaca gcaaggccgc cuucgagaga gagagcgacg ugccccugaa gaccgaggag      420

uucgagguga ccaagaccgc cguggcccac agacccggcg ccuucaaggc cgagcugagc      480

aagcugguga ucguggccaa ggccagcaga accgagcugu ga                         522


<210>  4415
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-25__Homo_sapiens__AAH10129

<400>  4415
auggccgcuc ccagcggcgg guggaacgga gugggcgccu cccugugggc ggcucuccug       60

cuuggggccg ucgcccugag accugcugag gccguuucug aaccgaccac aguggcuuuc      120

gacgugcggc ccggaggcgu cgugcacagc uuuucccaua auguugggcc uggagauaag      180

uacacgugca uguucaccua ugccucucag ggcggcacaa acgagcaaug gcagaugagc      240

cucgggaccu ccgaagacca ccagcauuuu acauguacca ucuggcgccc ccagggaaaa      300

ucuuaccugu auuucacaca auuuaaggcg gaggugagag gcgccgaaau ugaguacgcu      360

auggccuaua gcaaagcugc cuucgagcgg gaauccgaug ucccucuuaa gaccgaggaa      420

uuugagguga cgaaaaccgc gguugcccac cgccccgggg cuuucaaggc cgagcugagc      480

aagcucguga ucgucgcuaa agccucuaga acagaacugu ga                         522


<210>  4416
<211>  522
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-25__Homo_sapiens__AAH10129

<400>  4416
auggcagcac caucaggagg auggaaugga guaggcgcau cauuaugggc agcauuauua       60

uuaggagcag uagcauuaag accagcagaa gcaguaucag aaccaacaac aguagcauuc      120

gauguaagac caggaggagu uguacauuca uuuucacaua acguaggacc aggagauaaa      180

uauacaugua uguuuacaua ugcaucacaa ggaggaacaa acgaacaaug gcaaauguca      240

uuaggaacau cagaagauca ucaacauuuc acaugcacaa uauggagacc acaaggaaaa      300

ucauauuuau acuuuacaca auucaaagca gaaguaagag gagcagaaau agaauaugca      360

auggcauauu caaaagcagc auucgaaaga gaaucagaug uaccacuaaa aacagaagaa      420

uuugaaguaa caaaaacagc aguagcacac agaccaggag cauuuaaagc agaauuauca      480

aaacuaguaa uaguagcaaa agcaucaaga acagaacuau aa                         522


<210>  4417
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-25__Homo_sapiens__Q9H293

<400>  4417

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  4418
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-25__Homo_sapiens__AAG40848

<400>  4418
augagggagc gacccagauu aggugaggac aguucucuca uuagccuuuu ccuacaggug       60

guugcauucu uggcaauggu caugggaacc cacaccuaca gccacuggcc cagcugcugc      120

cccagcaaag ggcaggacac cucugaggag cugcugaggu ggagcacugu gccugugccu      180

ccccuagagc cugcuaggcc caaccgccac ccagaguccu guagggccag ugaagaugga      240

ccccucaaca gcagggccau cucccccugg agauaugagu uggacagaga cuugaaccgg      300

cucccccagg accuguacca cgcccguugc cugugcccgc acugcgucag ccuacagaca      360

ggcucccaca uggacccccg gggcaacucg gagcugcucu accacaacca gacugucuuc      420

uacaggcggc caugccaugg cgagaagggc acccacaagg gcuacugccu ggagcgcagg      480

cuguaccgug uuuccuuagc uugugugugu gugcggcccc gugugauggg cuag            534


<210>  4419
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-25__Homo_sapiens__AAG40848

<400>  4419
augcgcgagc ggccccgccu gggcgaggac agcucccuca ucagccuguu ccugcagguc       60

gucgccuucc ucgccauggu gauggggacc cacaccuacu cccacuggcc gagcugcugc      120

cccuccaagg gccaggacac gagcgaggag cugcugcggu gguccaccgu gcccgugccc      180

ccgcucgagc ccgcgcgccc caaccggcac cccgagagcu gccgcgccuc cgaggacggg      240

ccgcugaaca gccgggccau cucccccugg cgcuacgagc uggaccggga ccucaaccgc      300

cugccccagg accuguacca cgcccggugc cucugccccc acugcgugag ccugcagacc      360

ggcucccaca uggacccgcg cgggaacagc gagcugcucu accacaacca gaccguguuc      420

uaccggcgcc ccugccacgg cgagaagggc acgcacaagg gguacugccu ggagcggcgc      480

cuguaccggg ucucccucgc cugcgugugc gugcgccccc gggucauggg cuga            534


<210>  4420
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-25__Homo_sapiens__AAG40848

<400>  4420
augcgcgagc gcccccgccu cggcgaggac uccucccuca ucucccucuu ccuccagguc       60

gucgccuucc ucgccauggu caugggcacc cacaccuacu cccacuggcc cuccugcugc      120

cccuccaagg gccaggacac cuccgaggag cuccuccgcu gguccaccgu ccccgucccc      180

ccccucgagc ccgcccgccc caaccgccac cccgaguccu gccgcgccuc cgaggacggc      240

ccccucaacu cccgcgccau cucccccugg cgcuacgagc ucgaccgcga ccucaaccgc      300

cucccccagg accucuacca cgcccgcugc cucugccccc acugcgucuc ccuccagacc      360

ggcucccaca uggacccccg cggcaacucc gagcuccucu accacaacca gaccgucuuc      420

uaccgccgcc ccugccacgg cgagaagggc acccacaagg gcuacugccu cgagcgccgc      480

cucuaccgcg ucucccucgc cugcgucugc guccgccccc gcgucauggg cuga            534


<210>  4421
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-25__Homo_sapiens__AAG40848

<400>  4421
augagagaga ggccccggcu gggcgaagac agcucccuca ucucucuuuu ccugcaagug       60

gucgccuuuu uggcuauggu uauggggacc cacacauacu cacauuggcc uaguugcugu      120

ccaagcaagg gacaggauac uuccgaggaa uuacugcgcu ggucuacggu gccgguaccc      180

ccucuagagc cagcacgacc caaccgucac ccugaaucgu gcagagccuc agaggacggu      240

ccacucaaua gcagggcgau uagucccugg cgguaugagc uggaucgcga ccuuaacaga      300

cugccucagg auuuguacca ugcuaggugu cucugcccac acuguguguc ccugcagacc      360

ggcucucaua uggacccgcg ggggaauagc gaacugcucu aucacaacca gacagucuuc      420

uaccgccgac ccugccacgg agagaaaggc acucauaagg guuauuguuu agaaagaagg      480

cuguaccggg ugucccuugc cugcguuugu gugcguccuc gcgucauggg guga            534


<210>  4422
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-25__Homo_sapiens__AAG40848

<400>  4422
augagagaga gacccagacu gggcgaggac agcagccuga ucagccuguu ccugcaggug       60

guggccuucc uggccauggu gaugggcacc cacaccuaca gccacuggcc cagcugcugc      120

cccagcaagg gccaggacac cagcgaggag cugcugagau ggagcaccgu gcccgugccc      180

ccccuggagc ccgccagacc caacagacac cccgagagcu gcagagccag cgaggacggc      240

ccccugaaca gcagagccau cagccccugg agauacgagc uggacagaga ccugaacaga      300

cugccccagg accuguacca cgccagaugc cugugccccc acugcgugag ccugcagacc      360

ggcagccaca uggaccccag aggcaacagc gagcugcugu accacaacca gaccguguuc      420

uacagaagac ccugccacgg cgagaagggc acccacaagg gcuacugccu ggagagaaga      480

cuguacagag ugagccuggc cugcgugugc gugagaccca gagugauggg cuga            534


<210>  4423
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-25__Homo_sapiens__AAG40848

<400>  4423
augagagagc ggccccgccu gggcgaagac agcucccuca ucucucuguu ccuucaggug       60

gucgccuuuc uggcuauggu uauggggacc cacacauaca gccauuggcc uuccugcugu      120

ccgucuaagg gacaagauac gagcgaggaa cuccugagau gguccaccgu gcccgugccu      180

ccccuugagc cugcccggcc caaccgccac ccugaaucuu gcagagcgag cgaggacggc      240

ccgcucaauu cccgggcuau uagccccugg cgcuaugagc uggauagaga ccugaaccgg      300

cugccucagg aucucuacca ugcccgcugu cugugccccc acugugucuc ucuucagaca      360

gggucccaua uggacccuag aggaaauagc gaacugcucu aucacaacca gaccguguuc      420

uaccggcgcc ccugccacgg cgagaaaggg acacauaagg gauauugucu ggaaagacgg      480

cuuuaccgcg uuucucuggc cugcgugugu gucagaccgc gggugauggg cuga            534


<210>  4424
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-25__Homo_sapiens__AAG40848

<400>  4424
augagagaaa gaccaagauu aggagaagac ucaucacuaa uaucacuauu ucuacaagua       60

guagcauuuu uagcaauggu aaugggaaca cauacauauu cacauuggcc aucauguugc      120

ccaagcaaag gacaagacac aagcgaagaa cuacuaagau ggucaacagu accaguacca      180

ccacuagaac cagcaagacc aaacagacac ccagaaucau gcagagcauc agaagaugga      240

ccauuaaauu caagagcaau aucaccaugg agauacgaac uagauagaga uuuaaauaga      300

uuaccacaag acuuauacca ugcaagaugc uuaugcccac acuguguauc acuacaaaca      360

ggaucacaua uggauccaag aggaaauuca gaauuacuau accauaacca aacaguauuu      420

uauagaagac caugucacgg agaaaaagga acacacaaag gauauugcuu agaaagaaga      480

uuauacagag uaucacuagc augcguaugc guaagaccaa gaguaauggg auaa            534


<210>  4425
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-26__Homo_sapiens__Q9NPH9

<400>  4425

Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 
            20                  25                  30          


Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 
        35                  40                  45              


Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 
    50                  55                  60                  


Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 
65                  70                  75                  80  


Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 
                85                  90                  95      


Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 
            100                 105                 110         


Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 
        115                 120                 125             


Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 
145                 150                 155                 160 


Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 
                165                 170     


<210>  4426
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-26__Homo_sapiens__AAH66270

<400>  4426
augcugguga auuucauuuu gagguguggg uugcuguuag ucacucuguc ucuugccauu       60

gccaagcaca agcaaucuuc cuucaccaaa aguuguuacc caaggggaac auugucccaa      120

gcuguugacg cucucuauau caaagcagca uggcucaaag caacgauucc agaagaccgc      180

auaaaaaaua uacgauuauu aaaaaagaaa acaaaaaagc aguuuaugaa aaacugucaa      240

uuucaagaac agcuucuguc cuucuucaug gaagacguuu uuggucaacu gcaauugcaa      300

ggcugcaaga aaauacgcuu uguggaggac uuucauagcc uuaggcagaa auugagccac      360

uguauuuccu gugcuucauc agcuagagag augaaaucca uuaccaggau gaaaagaaua      420

uuuuauagga uuggaaacaa aggaaucuac aaagccauca gugaacugga uauucuucuu      480

uccuggauua aaaaauuauu ggaaagcagu caguaa                                516


<210>  4427
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-26__Homo_sapiens__AAH66270

<400>  4427
augcugguga acuucauccu ccgcugcggc cugcugcucg ucacccugag ccuggccauc       60

gccaagcaca agcaguccag cuucaccaag uccugcuacc cccgggggac gcucagccag      120

gcgguggacg cccuguacau caaggccgcc uggcugaagg ccaccauccc ggaggaccgc      180

aucaagaaca uccggcuccu gaagaagaag accaagaagc aguucaugaa gaacugccag      240

uuccaggagc agcugcucuc cuucuucaug gaggacgugu ucggccagcu gcagcugcag      300

gggugcaaga agauccgcuu cgucgaggac uuccacagcc uccggcagaa gcugucccac      360

ugcaucagcu gcgcguccag cgcccgcgag augaagucca ucacccggau gaagcgcauc      420

uucuaccgga ucggcaacaa ggggaucuac aaggccauca gcgagcugga cauccuccug      480

uccuggauca agaagcugcu cgagagcucc caguga                                516


<210>  4428
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-26__Homo_sapiens__AAH66270

<400>  4428
augcucguca acuucauccu ccgcugcggc cuccuccucg ucacccucuc ccucgccauc       60

gccaagcaca agcaguccuc cuucaccaag uccugcuacc cccgcggcac ccucucccag      120

gccgucgacg cccucuacau caaggccgcc uggcucaagg ccaccauccc cgaggaccgc      180

aucaagaaca uccgccuccu caagaagaag accaagaagc aguucaugaa gaacugccag      240

uuccaggagc agcuccucuc cuucuucaug gaggacgucu ucggccagcu ccagcuccag      300

ggcugcaaga agauccgcuu cgucgaggac uuccacuccc uccgccagaa gcucucccac      360

ugcaucuccu gcgccuccuc cgcccgcgag augaagucca ucacccgcau gaagcgcauc      420

uucuaccgca ucggcaacaa gggcaucuac aaggccaucu ccgagcucga cauccuccuc      480

uccuggauca agaagcuccu cgaguccucc caguga                                516


<210>  4429
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-26__Homo_sapiens__AAH66270

<400>  4429
augcugguga acuucauacu cagaugcggc cuucuguugg ucaccuuaag ccuggccauu       60

gcuaagcaca aacaguccuc uuuuacaaag ucauguuacc ccagggggac ucuaagucaa      120

gcaguugacg cccucuauau aaaagcggcu uggcugaagg ccacgauccc ugaggaucgg      180

auuaaaaaua uccgccuucu gaagaagaaa accaagaaac aguucaugaa gaacugccag      240

uuucaggaac aauugcucag cuucuuuaug gaggacgugu ucggacagcu gcagcugcag      300

gguuguaaaa agauucgauu uguagaagau uuccauuccc uccgucaaaa guuaucucac      360

ugcaucucgu gugcaucaag cgccagagag augaaaagua uaacaaggau gaagcggauc      420

uuuuaccgca uuggcaauaa agggaucuau aaggcuauuu ccgaacugga cauccuuuug      480

ucuuggauca aaaagcugcu agagagcucc caguga                                516


<210>  4430
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-26__Homo_sapiens__AAH66270

<400>  4430
augcugguga acuucauccu gagaugcggc cugcugcugg ugacccugag ccuggccauc       60

gccaagcaca agcagagcag cuucaccaag agcugcuacc ccagaggcac ccugagccag      120

gccguggacg cccuguacau caaggccgcc uggcugaagg ccaccauccc cgaggacaga      180

aucaagaaca ucagacugcu gaagaagaag accaagaagc aguucaugaa gaacugccag      240

uuccaggagc agcugcugag cuucuucaug gaggacgugu ucggccagcu gcagcugcag      300

ggcugcaaga agaucagauu cguggaggac uuccacagcc ugagacagaa gcugagccac      360

ugcaucagcu gcgccagcag cgccagagag augaagagca ucaccagaau gaagagaauc      420

uucuacagaa ucggcaacaa gggcaucuac aaggccauca gcgagcugga cauccugcug      480

agcuggauca agaagcugcu ggagagcagc caguga                                516


<210>  4431
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-26__Homo_sapiens__AAH66270

<400>  4431
augcugguga acuucauccu cagaugcggc cugcuucugg ucacccucag ccuggccauu       60

gcuaagcaca aacaguccuc uuuuacaaag agcuguuacc cccgggggac gcuuucccaa      120

gccguugacg cgcuguauau caaagcugcc uggcucaagg ccaccauucc ugaggaucgc      180

aucaaaaaua uuagacugcu gaagaagaaa acaaagaaac aguucaugaa gaacugccag      240

uuucaggaac aacuccuguc uuucuuuaug gaggacgugu ucggacagcu ucagcugcag      300

ggcuguaaaa agauccgguu uguggaagau uuccauagcc uccgccaaaa gcugucccac      360

ugcaucucuu gugcuagcuc cgccagagag augaaaagca uuacccggau gaagcgcauc      420

uuuuacagaa uugggaauaa aggaaucuau aaggcuauuu cugaacuuga cauccugcuc      480

uccuggauua aaaagcugcu ggagagcucu caguga                                516


<210>  4432
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-26__Homo_sapiens__AAH66270

<400>  4432
augcuaguaa acuucauacu aagaugcgga cuacuacuag uaacccuauc acuagcaaua       60

gcaaaacaca aacaaucauc auucacaaaa uccugcuacc caagaggaac cuuaucacaa      120

gcaguagacg cauuauacau aaaagcagca uggcuaaaag caaccauacc agaagacaga      180

auaaaaaaca uaagacuacu aaaaaaaaaa acaaaaaaac aauucaugaa aaacugccaa      240

uuccaagaac aacuacuauc auucuucaug gaagacguau ucggacaacu acaacuacaa      300

ggaugcaaaa aaauaagauu cguagaagac uuccacucac uaagacaaaa acuaucccac      360

ugcauaucau gcgcaagcuc agcaagagaa augaaaucaa uaacaagaau gaaaagaaua      420

uucuacagaa uaggaaacaa aggaauauac aaagcaauau cagaacuaga cauacuacua      480

ucauggauca aaaaacuacu cgaaucauca caauaa                                516


<210>  4433
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-27A__Homo_sapiens__Q8NEV9

<400>  4433

Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210>  4434
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-27A__Homo_sapiens__ABK41903

<400>  4434
augggccaga cggcaggcga ccuuggcugg cggcucagcc uguugcugcu ucccuugcuc       60

cugguucaag cuggugucug gggauuccca aggcccccag ggaggcccca gcugagccug      120

caggagcugc ggagggaguu cacagucagc cugcaucucg ccaggaagcu gcucuccgag      180

guucggggcc aggcccaccg cuuugcggaa ucucaccugc caggagugaa ccuguaccuc      240

cugccccugg gagagcagcu cccugauguu ucccugaccu uccaggccug gcgccgccuc      300

ucugacccgg agcgucucug cuucaucucc accacgcuuc agcccuucca ugcccugcug      360

ggagggcugg ggacccaggg ccgcuggacc aacauggaga ggaugcagcu gugggccaug      420

aggcuggacc uccgcgaucu gcagcggcac cuccgcuucc aggugcuggc ugcaggauuc      480

aaccucccgg aggaggagga ggaggaagag gaggaggagg aggaggagag gaaggggcug      540

cucccagggg cacugggcag cgccuuacag ggcccggccc agguguccug gccccagcuc      600

cucuccaccu accgccugcu gcacuccuug gagcucgucu uaucucgggc cgugcgggag      660

uugcugcugc uguccaaggc ugggcacuca gucuggcccu ugggguuccc aacauugagc      720

ccccagcccu ga                                                          732


<210>  4435
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4435
augggccaga ccgccgggga ccugggcugg cgccucuccc ugcugcuccu gccccugcuc       60

cuggugcagg ccggggucug gggcuucccg cggccgcccg ggcgccccca gcugucccuc      120

caggagcugc ggcgcgaguu caccgugagc cugcaccucg cgcggaagcu gcuguccgag      180

gugcgcggcc aggcccaccg guucgccgag agccaccucc ccggcgucaa ccuguaccug      240

cucccccugg gggagcagcu gcccgacgug ucccucacgu uccaggccug gcgccggcug      300

agcgaccccg agcgccugug cuucaucucc accacccucc agccguucca cgcccugcug      360

ggcgggcucg gcacccaggg gcgguggacg aacauggagc gcaugcagcu gugggcgaug      420

cggcuggacc uccgcgaccu gcagcggcac cuccgcuucc aggugcuggc cgccggcuuc      480

aaccugcccg aggaggagga ggaggaggag gaggaggagg aggaggagcg gaagggccug      540

cuccccgggg cccugggcag cgcgcugcag gggcccgccc aggucuccug gccgcagcuc      600

cugagcaccu accgccugcu ccacucccug gagcuggugc ucagccgggc cgugcgcgag      660

cugcugcucc uguccaaggc cggccacagc gucuggcccc ugggcuuccc cacccugagc      720

ccccagccgu ga                                                          732


<210>  4436
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4436
augggccaga ccgccggcga ccucggcugg cgccucuccc uccuccuccu cccccuccuc       60

cucguccagg ccggcgucug gggcuucccc cgcccccccg gccgccccca gcucucccuc      120

caggagcucc gccgcgaguu caccgucucc cuccaccucg cccgcaagcu ccucuccgag      180

guccgcggcc aggcccaccg cuucgccgag ucccaccucc ccggcgucaa ccucuaccuc      240

cucccccucg gcgagcagcu ccccgacguc ucccucaccu uccaggccug gcgccgccuc      300

uccgaccccg agcgccucug cuucaucucc accacccucc agcccuucca cgcccuccuc      360

ggcggccucg gcacccaggg ccgcuggacc aacauggagc gcaugcagcu cugggccaug      420

cgccucgacc uccgcgaccu ccagcgccac cuccgcuucc agguccucgc cgccggcuuc      480

aaccuccccg aggaggagga ggaggaggag gaggaggagg aggaggagcg caagggccuc      540

cuccccggcg cccucggcuc cgcccuccag ggccccgccc aggucuccug gccccagcuc      600

cucuccaccu accgccuccu ccacucccuc gagcucgucc ucucccgcgc cguccgcgag      660

cuccuccucc ucuccaaggc cggccacucc gucuggcccc ucggcuuccc cacccucucc      720

ccccagcccu ga                                                          732


<210>  4437
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4437
augggccaga ccgccgggga ccugggaugg agacucagcc uucuguuguu accccugcua       60

cucgugcaag cuggugucug gggcuucccu aggccaccgg ggcggcccca gcugucccuu      120

caggagcugc gccgagaauu uacaguuucu uugcaccucg cacguaagcu gcugucagag      180

gugagaggac aggcccauag guucgcggaa agucaccucc cuggcguaaa cuuauaccug      240

cuuccauugg gugagcaacu gcccgaugug agccuaacuu uucaggcuug gcggcgccuc      300

uccgacccug aaagacugug cuucaucucu acgacccuuc agccauuuca ugcccuguug      360

ggcggacucg gcacacaggg gagguggacu aauauggagc ggaugcaacu gugggcaaug      420

cgcuuagauc ugcgagaccu ccagagacac cuuagguucc agguccuggc cgcuggguuu      480

aacuugcccg aggaagagga agaggaggaa gaggaagagg aagaggagcg gaaaggacua      540

cugccuggug cacucggcuc ggcccugcag gggccagcuc aagugucaug gccgcagcuu      600

cugagcaccu aucguuugcu ccauagucug gaauuaguuc ugucccgcgc cgugagagag      660

cuacuccugc uuucuaaggc gggacacagc gucuggcccu ugggcuuccc uacacugucc      720

ccacagcccu ga                                                          732


<210>  4438
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4438
augggccaga ccgccggcga ccugggcugg agacugagcc ugcugcugcu gccccugcug       60

cuggugcagg ccggcgugug gggcuucccc agaccccccg gcagacccca gcugagccug      120

caggagcuga gaagagaguu caccgugagc cugcaccugg ccagaaagcu gcugagcgag      180

gugagaggcc aggcccacag auucgccgag agccaccugc ccggcgugaa ccuguaccug      240

cugccccugg gcgagcagcu gcccgacgug agccugaccu uccaggccug gagaagacug      300

agcgaccccg agagacugug cuucaucagc accacccugc agcccuucca cgcccugcug      360

ggcggccugg gcacccaggg cagauggacc aacauggaga gaaugcagcu gugggccaug      420

agacuggacc ugagagaccu gcagagacac cugagauucc aggugcuggc cgccggcuuc      480

aaccugcccg aggaggagga ggaggaggag gaggaggagg aggaggagag aaagggccug      540

cugcccggcg cccugggcag cgcccugcag ggccccgccc aggugagcug gccccagcug      600

cugagcaccu acagacugcu gcacagccug gagcuggugc ugagcagagc cgugagagag      660

cugcugcugc ugagcaaggc cggccacagc guguggcccc ugggcuuccc cacccugagc      720

ccccagcccu ga                                                          732


<210>  4439
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4439
augggccaga ccgccgggga ccugggaugg agacucagcc ugcuucugcu cccccugcuu       60

cuggugcaag cuggcgucug gggguucccu cggccgcccg gacgcccuca gcucucccug      120

caggagcuga gacgggaauu uacaguuucu cuccaccugg cccgcaagcu gcugagcgag      180

gugagaggcc aggcgcaucg guucgcugaa ucccaccucc ccggggugaa ccuguaccuu      240

cugccucucg gagagcaacu gcccgauguc ucucugacgu uucaggccug gcgcagacuc      300

agcgacccug aacggcugug cuucaucucc accacacuuc agccguuuca ugcccugcuc      360

ggcggccugg ggacccaggg acgcuggaca aauauggaga gaaugcaacu uugggcuaug      420

cggcuggauc uccgcgaccu gcagagacac cuucgguucc aggugcucgc cgcuggcuuu      480

aaccugcccg aggaagagga agaggaggaa gaggaagagg aagaggagcg caaagggcuu      540

cugccuggag cccucggcuc ugcgcugcag gggcccgccc aaguuagcug gccucagcuu      600

cuguccaccu auagacuccu gcauagccug gaacucgugc ugucucgggc ugucagagag      660

cuucugcucc uguccaaggc cggacacagc guguggcccc ugggcuuccc gacacuuucu      720

ccucagcccu ga                                                          732


<210>  4440
<211>  732
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-27A__Homo_sapiens__ABK41903

<400>  4440
augggacaaa cagcaggaga cuuaggaugg agauuaucac uacucuuauu accacuccua       60

cuaguacaag cuggaguuug gggauucccu agaccaccag gaagaccaca auuaagcuua      120

caagaacuaa gaagagaauu uacuguauca cuacaucuag caagaaaauu auuaucagaa      180

guaagaggac aagcacacag auucgcagaa ucccaucuac caggaguaaa cuuauacuua      240

cuaccacuag gcgaacaacu accagacguu ucauuaaccu uucaagcuug gagaagauua      300

ucagauccag aaagauuaug cuuuauaucc acaacacuac aacccuuuca cgcacuauua      360

ggaggucuag gaacacaagg aagauggacu aacauggaaa gaaugcaauu augggccaug      420

agauuagacu uaagagaucu acaaagacau uuaagauucc aaguacuagc agcaggauuu      480

aaccuaccag aagaagaaga agaagaagaa gaagaagaag aagaagaaag aaaaggccuu      540

cuaccaggag cacuaggaag cgcacuacaa ggaccagccc aaguaucaug gccccaauua      600

cuaucaacau auagauuacu acauagccua gaauuaguau uaucaagagc aguaagagaa      660

cuauuacuau uaagcaaagc aggacacucu guauggccac uagguuuucc aacacuaucu      720

ccacaaccau aa                                                          732


<210>  4441
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-27B__Homo_sapiens__Q14213

<400>  4441

Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro 
1               5                   10                  15      


Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg 
            20                  25                  30          


Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp 
        35                  40                  45              


Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala 
    50                  55                  60                  


Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu 
65                  70                  75                  80  


Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu 
                85                  90                  95      


Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp 
            100                 105                 110         


Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys 
        115                 120                 125             


Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln 
    130                 135                 140                 


Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile 
145                 150                 155                 160 


Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg 
                165                 170                 175     


Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala 
            180                 185                 190         


Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu 
        195                 200                 205             


Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr 
    210                 215                 220                 


Met Ser Leu Gly Lys 
225                 


<210>  4442
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-27B__Homo_sapiens__AAC33488

<400>  4442
augaccccgc agcuucuccu ggcccuuguc cucugggcca gcugcccgcc cugcagugga       60

aggaaagggc ccccagcagc ucugacacug ccccgggugc aaugccgagc cucucgguac      120

ccgaucgccg uggauugcuc cuggacccug ccgccugcuc caaacuccac cagccccgug      180

uccuucauug ccacguacag gcucggcaug gcugcccggg gccacagcug gcccugccug      240

cagcagacgc caacguccac cagcugcacc aucacggaug uccagcuguu cuccauggcu      300

cccuacgugc ucaaugucac cgccguccac cccuggggcu ccagcagcag cuucgugccu      360

uucauaacag agcacaucau caagcccgac ccuccagaag gcgugcgccu aagcccccuc      420

gcugagcgcc agcuacaggu gcagugggag ccucccgggu ccuggcccuu cccagagauc      480

uucucacuga aguacuggau ccguuacaag cgucagggag cugcgcgcuu ccaccgggug      540

gggcccauug aagccacguc cuucauccuc agggcugugc ggccccgagc cagguacuac      600

guccaagugg cggcucagga ccucacagac uacggggaac ugagugacug gagucucccc      660

gccacugcca caaugagccu gggcaaguag                                       690


<210>  4443
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4443
augacgcccc agcugcuccu ggcccuggug cucugggcca gcugcccgcc cugcuccggc       60

cgcaaggggc cgcccgcggc ccugacccug ccccgggucc agugccgcgc cagccgguac      120

cccaucgccg uggacugcuc cuggacccuc ccgcccgccc ccaacagcac cucccccgug      180

agcuucaucg cgaccuaccg ccugggcaug gccgcccggg ggcacuccug gcccugccug      240

cagcagaccc ccacgagcac cuccugcacc aucaccgacg uccagcuguu cagcauggcc      300

ccguacgugc ucaacgugac ggcgguccac cccuggggcu ccagcuccag cuucgugccc      360

uucaucaccg agcacaucau caagcccgac ccgcccgagg gggugcgccu gagcccccuc      420

gccgagcggc agcugcaggu ccagugggag cccccgggcu ccuggcccuu ccccgagauc      480

uucucccuga aguacuggau ccgcuacaag cggcagggcg ccgcccgcuu ccaccgggug      540

gggcccaucg aggccaccag cuucauccuc cgcgcggugc ggccgcgcgc ccgguacuac      600

guccaggugg ccgcccagga ccugaccgac uacggcgagc uguccgacug gagccucccc      660

gccacggcga ccaugagccu ggggaaguga                                       690


<210>  4444
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4444
augacccccc agcuccuccu cgcccucguc cucugggccu ccugcccccc cugcuccggc       60

cgcaagggcc cccccgccgc ccucacccuc ccccgcgucc agugccgcgc cucccgcuac      120

cccaucgccg ucgacugcuc cuggacccuc ccccccgccc ccaacuccac cucccccguc      180

uccuucaucg ccaccuaccg ccucggcaug gccgcccgcg gccacuccug gcccugccuc      240

cagcagaccc ccaccuccac cuccugcacc aucaccgacg uccagcucuu cuccauggcc      300

cccuacgucc ucaacgucac cgccguccac cccuggggcu ccuccuccuc cuucgucccc      360

uucaucaccg agcacaucau caagcccgac ccccccgagg gcguccgccu cuccccccuc      420

gccgagcgcc agcuccaggu ccagugggag ccccccggcu ccuggcccuu ccccgagauc      480

uucucccuca aguacuggau ccgcuacaag cgccagggcg ccgcccgcuu ccaccgcguc      540

ggccccaucg aggccaccuc cuucauccuc cgcgccgucc gcccccgcgc ccgcuacuac      600

guccaggucg ccgcccagga ccucaccgac uacggcgagc ucuccgacug gucccucccc      660

gccaccgcca ccaugucccu cggcaaguga                                       690


<210>  4445
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4445
augacacccc agcugcuccu ugcccuggug uugugggcua gcugcccucc auguuccggc       60

agaaaggggc cgcccgcagc cuuaacccug ccuagggucc aaugccgggc gucucgcuac      120

ccaaucgcug uugacuguuc auggacucua cccccugccc caaacaguac gagccccgug      180

uccuucauug caaccuaucg acucggaaug gccgcucgug gucacucuug gccuugccug      240

cagcagacac caacuucgac cucauguaca auaaccgaug uacagcuuuu uagcauggca      300

ccguacgugc ugaaugucac ugccgugcau cccuggggca guuccucuag cuucguuccu      360

uuuaucacag agcacauuau caaaccagau cccccugaag gggugagauu guccccacuc      420

gcugagaggc aacugcaggu ccagugggaa cccccgggau cauggccuuu ccccgagauu      480

uuuagucuga aguauuggau ccgguacaaa cgccagggcg ccgcgagauu ccauagggug      540

gguccaauag aagcaaccag cuuuauccuc cgggccguac gcccucgagc uagauauuac      600

guucaagugg ccgcacagga cuuaacggac uauggggagc ugucugauug gucccuuccc      660

gcuacugcca ccaugucauu gggaaaguga                                       690


<210>  4446
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4446
augacccccc agcugcugcu ggcccuggug cugugggcca gcugcccccc cugcagcggc       60

agaaagggcc cccccgccgc ccugacccug cccagagugc agugcagagc cagcagauac      120

cccaucgccg uggacugcag cuggacccug ccccccgccc ccaacagcac cagccccgug      180

agcuucaucg ccaccuacag acugggcaug gccgccagag gccacagcug gcccugccug      240

cagcagaccc ccaccagcac cagcugcacc aucaccgacg ugcagcuguu cagcauggcc      300

cccuacgugc ugaacgugac cgccgugcac cccuggggca gcagcagcag cuucgugccc      360

uucaucaccg agcacaucau caagcccgac ccccccgagg gcgugagacu gagcccccug      420

gccgagagac agcugcaggu gcagugggag ccccccggca gcuggcccuu ccccgagauc      480

uucagccuga aguacuggau cagauacaag agacagggcg ccgccagauu ccacagagug      540

ggccccaucg aggccaccag cuucauccug agagccguga gacccagagc cagauacuac      600

gugcaggugg ccgcccagga ccugaccgac uacggcgagc ugagcgacug gagccugccc      660

gccaccgcca ccaugagccu gggcaaguga                                       690


<210>  4447
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4447
augacacccc agcugcuccu ggcccuugug cugugggcua gcugcccucc guguuccggc       60

agaaaggggc ccccugccgc gcucacccug ccccgggucc aaugccgcgc uucuagauac      120

ccuaucgccg uugacuguag cuggacgcuu cccccugccc cgaacuccac cucucccgug      180

agcuucauug cuacauaucg gcugggaaug gccgcucgcg gccacuccug gccuugccuc      240

cagcagaccc ccacaucuac cagcuguaca aucaccgaug ugcagcuguu uuccauggcc      300

ccuuacgucc ugaaugugac ggcgguucau cccugggggu cuagcuccag cuucgugccg      360

uuuauuaccg agcacaucau uaaaccugau cccccugaag gagucagacu cucuccccug      420

gccgagcggc aacuucaggu gcagugggaa cccccuggcu ccuggccguu ccccgagauc      480

uuuagccuga aguauuggau ccgcuacaaa agacaggggg cugcccgguu ccaucgcguu      540

ggaccuauug aagcuacauc uuuuauccuc agagccgugc ggccccgcgc gagauauuac      600

guccaagugg ccgcucagga ccugaccgac uauggcgagc uuuccgauug gagccugccu      660

gccacagcua ccaugucccu cggcaaguga                                       690


<210>  4448
<211>  690
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-27B__Homo_sapiens__AAC33488

<400>  4448
augacaccac aacuauuauu agcacuagua cuaugggcau caugcccacc augcucagga       60

agaaaaggac ccccagcugc auuaacacua ccaagaguac aaugcagagc aucaagauac      120

ccaauagcag uagacugcuc auggacacua ccaccagccc caaacucaac aucaccagua      180

ucauucaucg caacauacag acuaggaaug gcagcaagag gacacucaug gccaugccua      240

caacaaacac cuacaucaac auccugcaca auaacagacg uacaauuauu uucaauggca      300

ccauacguac uaaacguaac agcaguacac ccauggggau caucaagcuc auucguccca      360

uucauaacag aacacauaau aaaaccagac ccacccgaag gagucagacu aucaccauua      420

gcagaaagac aauuacaagu acaaugggaa ccaccaggau cuuggccauu cccagaaaua      480

uucucccuaa aauauuggau acgauacaaa agacaaggag cagcaagauu ucauagagua      540

ggaccaauag aagcaacauc auucauauua agagcaguaa gaccaagagc aagauacuac      600

guccaaguag cugcacaaga ccuaacagac uacggagaac uaucagacug gucauuaccu      660

gcaacagcaa caaugucccu aggaaaauaa                                       690


<210>  4449
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-28A__Homo_sapiens__Q8IZJ0

<400>  4449

Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  4450
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-28A__Homo_sapiens__AAI13582

<400>  4450
augaaacuag acaugacugg ggacugcacg ccagugcugg ugcugauggc cgcagugcug       60

accgugacug gagcaguucc ugucgccagg cuccacgggg cucucccgga ugcaaggggc      120

ugccacauag cccaguucaa gucccugucu ccacaggagc ugcaggccuu uaagagggcc      180

aaagaugccu uagaagaguc gcuucugcug aaggacugca ggugccacuc ccgccucuuc      240

cccaggaccu gggaccugag gcagcugcag gugagggagc gccccauggc uuuggaggcu      300

gagcuggccc ugacgcugaa gguucuggag gccaccgcug acacugaccc agcccuggug      360

gacgucuugg accagccccu ucacacccug caccauaucc ucucccaguu ccgggccugu      420

auccagccuc agcccacggc agggcccagg acccggggcc gccuccacca uuggcuguac      480

cggcuccagg aggccccaaa aaaggagucc ccuggcugcc ucgaggccuc ugucaccuuc      540

aaccucuucc gccuccucac gcgagaccug aauuguguug ccagugggga ccuguguguc      600

uga                                                                    603


<210>  4451
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4451
augaagcugg acaugaccgg cgacugcacc cccgugcucg uccugauggc cgccgugcug       60

acggugaccg gggcgguccc gguggcccgc cuccacggcg cccugcccga cgcccggggg      120

ugccacaucg cccaguucaa gagccugagc ccccaggagc uccaggcguu caagcgcgcc      180

aaggacgccc uggaggaguc ccugcuccug aaggacugcc ggugccacuc ccgccuguuc      240

ccccggaccu gggaccuccg ccagcuccag gugcgggagc gcccgauggc ccuggaggcg      300

gagcuggccc ugacccugaa gguccucgag gccacggccg acaccgaccc cgcccuggug      360

gacgugcugg accagccccu ccacacccug caccacaucc ugagccaguu ccgggcgugc      420

auccagcccc agccgaccgc cggcccccgc acgcgggggc gccuccacca cuggcuguac      480

cggcugcagg aggcccccaa gaaggagucc cccggcugcc ucgaggccag cgucaccuuc      540

aaccuguucc gccugcucac ccgggaccug aacugcgugg ccuccggcga ccugugcgug      600

uga                                                                    603


<210>  4452
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4452
augaagcucg acaugaccgg cgacugcacc cccguccucg uccucauggc cgccguccuc       60

accgucaccg gcgccguccc cgucgcccgc cuccacggcg cccuccccga cgcccgcggc      120

ugccacaucg cccaguucaa gucccucucc ccccaggagc uccaggccuu caagcgcgcc      180

aaggacgccc ucgaggaguc ccuccuccuc aaggacugcc gcugccacuc ccgccucuuc      240

ccccgcaccu gggaccuccg ccagcuccag guccgcgagc gccccauggc ccucgaggcc      300

gagcucgccc ucacccucaa gguccucgag gccaccgccg acaccgaccc cgcccucguc      360

gacguccucg accagccccu ccacacccuc caccacaucc ucucccaguu ccgcgccugc      420

auccagcccc agcccaccgc cggcccccgc acccgcggcc gccuccacca cuggcucuac      480

cgccuccagg aggcccccaa gaaggagucc cccggcugcc ucgaggccuc cgucaccuuc      540

aaccucuucc gccuccucac ccgcgaccuc aacugcgucg ccuccggcga ccucugcguc      600

uga                                                                    603


<210>  4453
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4453
augaagcugg acaugaccgg cgauugcaca cccgugcucg uccuuauggc cgcuguucug       60

acugugacgg gggcaguacc uguggccaga uugcacggag cguuaccaga cgcuaggggu      120

ugucauaucg cccaguucaa aagccugucc ccgcaagagc uacaggcauu uaagcgggcc      180

aaagaugcuc ucgaagaguc ucugcuucug aaggacugcc gcugucacuc acgauuguuc      240

ccccguaccu gggaucucag acagcugcag gucagggaac ggccuauggc acuggaggcc      300

gaacucgcuu uaacacugaa agugcuugag gccacugcgg acaccgaucc agcauugguu      360

gacgugcugg aucaaccccu acauacacuc caccauauuc ugagucaguu ucgcgccugc      420

auacagccuc agccaaccgc uggccccaga acuagggggc ggcuucacca cuggcuguac      480

cgcuugcaag aggccccuaa gaaggaaagc ccaggauguc ucgaggcauc cgucacauuc      540

aaccuguuuc gauuacugac cagagaccuc aauugcgugg cuucuggcga ucuuugugua      600

uga                                                                    603


<210>  4454
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4454
augaagcugg acaugaccgg cgacugcacc cccgugcugg ugcugauggc cgccgugcug       60

accgugaccg gcgccgugcc cguggccaga cugcacggcg cccugcccga cgccagaggc      120

ugccacaucg cccaguucaa gagccugagc ccccaggagc ugcaggccuu caagagagcc      180

aaggacgccc uggaggagag ccugcugcug aaggacugca gaugccacag cagacuguuc      240

cccagaaccu gggaccugag acagcugcag gugagagaga gacccauggc ccuggaggcc      300

gagcuggccc ugacccugaa ggugcuggag gccaccgccg acaccgaccc cgcccuggug      360

gacgugcugg accagccccu gcacacccug caccacaucc ugagccaguu cagagccugc      420

auccagcccc agcccaccgc cggccccaga accagaggca gacugcacca cuggcuguac      480

agacugcagg aggcccccaa gaaggagagc cccggcugcc uggaggccag cgugaccuuc      540

aaccuguuca gacugcugac cagagaccug aacugcgugg ccagcggcga ccugugcgug      600

uga                                                                    603


<210>  4455
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4455
augaagcugg acaugaccgg cgauugcaca cccgugcucg uccugauggc cgcuguucuu       60

acggugaccg gggccgugcc ugucgcgaga cugcacggag cucucccgga cgcccggggc      120

ugucauaucg cccaguucaa aagccugucu ccccaagagc uucaggcuuu uaagcgcgcc      180

aaagaugcuc uggaagaguc ccuccugcug aaggacugca gaugucacag ccgccucuuc      240

ccucggacau gggaucugag acagcuucag gugcgggaac gccccauggc ccuggaggcg      300

gaacucgccc ugacccuuaa aguucuggag gcuacagccg acaccgaucc ugcucucgug      360

gacguccugg aucaaccccu gcauacacuc caccauauuc ugucccaguu uagagccugc      420

auccagccuc agccgaccgc ggggccccgg acgcgcggaa gacuucacca cuggcuguac      480

cggcuccaag aggccccuaa gaaggaaucu cccggcuguc uggaggcuag cgugaccuuc      540

aaccuuuuuc gccugcucac aagagaccug aauugcguug ccuccgggga ucugugugug      600

uga                                                                    603


<210>  4456
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-28A__Homo_sapiens__AAI13582

<400>  4456
augaaauuag acaugacagg agacuguaca ccaguacucg uacuaauggc agcaguacua       60

acaguuacag gagcaguacc aguagcaaga cuacacggag cacuaccaga cgcaagagga      120

ugucacauag cacaauucaa aucauuauca ccacaagaac uccaagcauu uaaaagagcc      180

aaagacgcac uagaagaauc auuacuauua aaagacugca gaugccacuc acgacuauuc      240

ccaagaacau gggaccuaag acaacuacaa guaagagaaa gaccaauggc auuagaagcc      300

gaacuagcau uaacauuaaa aguacuagaa gcaacagcag acacagaucc agcccuaguc      360

gacguacuag accaaccacu acacacacua caccacauac uaucacaauu uagagccugc      420

auacaaccac aaccaacagc aggaccacga acaagaggca gacuacacca cuggcuauac      480

agacuacaag aagccccaaa aaaagaauca ccaggaugcc uagaagcauc aguaacauuc      540

aaccuauuca gacuauuaac aagagaccua aacugcguag caucaggaga ccuaugcgua      600

uaa                                                                    603


<210>  4457
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-28B__Homo_sapiens__Q8IZI9

<400>  4457

Met Thr Gly Asp Cys Met Pro Val Leu Val Leu Met Ala Ala Val Leu 
1               5                   10                  15      


Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro 
            20                  25                  30          


Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln 
        35                  40                  45              


Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu 
    50                  55                  60                  


Leu Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala 
                85                  90                  95      


Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp 
            100                 105                 110         


Pro Ala Leu Gly Asp Val Leu Asp Gln Pro Leu His Thr Leu His His 
        115                 120                 125             


Ile Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly 
    130                 135                 140                 


Pro Arg Thr Arg Gly Arg Leu His His Trp Leu His Arg Leu Gln Glu 
145                 150                 155                 160 


Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe 
                165                 170                 175     


Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly 
            180                 185                 190         


Asp Leu Cys Val 
        195     


<210>  4458
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-28B__Homo_sapiens__AAI30315

<400>  4458
augaccgggg acugcaugcc agugcuggug cugauggccg cagugcugac cgugacugga       60

gcaguuccug ucgccaggcu ccgcggggcu cucccggaug caaggggcug ccacauagcc      120

caguucaagu cccugucucc acaggagcug caggccuuua agagggccaa agaugccuua      180

gaagagucgc uucugcugaa ggacugcaag ugccgcuccc gccucuuccc caggaccugg      240

gaccugaggc agcugcaggu gagggagcgc cccguggcuu uggaggcuga gcuggcccug      300

acgcugaagg uucuggaggc caccgcugac acugacccag cccuggggga ugucuuggac      360

cagccccuuc acacccugca ccauauccuc ucccagcucc gggccuguau ccagccucag      420

cccacggcag ggcccaggac ccggggccgc cuccaccauu ggcugcaccg gcuccaggag      480

gccccaaaaa aggagucccc uggcugccuc gaggccucug ucaccuucaa ccucuuccgc      540

cuccucacgc gagaccugaa uuguguugcc agcggggacc ugugugucug a               591


<210>  4459
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4459
augaccggcg acugcaugcc cgugcugguc cucauggccg ccgugcugac cgugacgggg       60

gcggucccgg uggcccgccu gcggggcgcc cuccccgacg cccgcgggug ccacaucgcc      120

caguucaaga gccugagccc ccaggagcug caggcguuca agcgggccaa ggacgcccuc      180

gaggaguccc ugcugcucaa ggacugcaag ugccgcuccc ggcuguuccc ccgcaccugg      240

gaccugcggc agcuccaggu gcgcgagcgg ccggucgccc uggaggcgga gcuggcccuc      300

acccugaagg ugcuggaggc caccgccgac acggaccccg cccucggcga cgugcuggac      360

cagccccugc acacccucca ccacauccug agccagcugc gcgcgugcau ccagccccag      420

ccgaccgccg ggccccggac ccgcggccgg cuccaccacu ggcugcaccg ccugcaggag      480

gcccccaaga aggagucccc cggcugccuc gaggccagcg ucacguucaa ccuguuccgg      540

cugcucaccc gcgaccugaa cugcguggcc uccggggacc ugugcgugug a               591


<210>  4460
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4460
augaccggcg acugcaugcc cguccucguc cucauggccg ccguccucac cgucaccggc       60

gccguccccg ucgcccgccu ccgcggcgcc cuccccgacg cccgcggcug ccacaucgcc      120

caguucaagu cccucucccc ccaggagcuc caggccuuca agcgcgccaa ggacgcccuc      180

gaggaguccc uccuccucaa ggacugcaag ugccgcuccc gccucuuccc ccgcaccugg      240

gaccuccgcc agcuccaggu ccgcgagcgc cccgucgccc ucgaggccga gcucgcccuc      300

acccucaagg uccucgaggc caccgccgac accgaccccg cccucggcga cguccucgac      360

cagccccucc acacccucca ccacauccuc ucccagcucc gcgccugcau ccagccccag      420

cccaccgccg gcccccgcac ccgcggccgc cuccaccacu ggcuccaccg ccuccaggag      480

gcccccaaga aggagucccc cggcugccuc gaggccuccg ucaccuucaa ccucuuccgc      540

cuccucaccc gcgaccucaa cugcgucgcc uccggcgacc ucugcgucug a               591


<210>  4461
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4461
augaccggcg acugcaugcc cgugcugguc cucauggccg cuguucuuac agugacuggg       60

gcaguaccug uggccagacu gaggggagcg uugccagaug cucgggguug ucacaucgcc      120

caguucaaga gcuuaucccc gcaagagcug caggcauuua aacgcgccaa ggacgcucua      180

gaagagucuc uccugcuuaa agauugcaag ugucgaucac gucuguuccc cagaacgugg      240

gacuugaggc agcuccaggu ccgggaacgc ccuguggcac uggaggccga acuggcucuc      300

accuuaaaag uucuggaggc cacagcggau acugacccag cacuuggcga uguguuggac      360

caaccccugc auacccuaca ccauauucuc agucagcuga gagccugcau acagccucag      420

ccaacagcug ggcccaggac ccggggacgc cuucaccauu ggcugcaccg auugcaagag      480

gccccuaaga aggaaagccc aggcugucuc gaggcauccg ucacuuuuaa ccuguucaga      540

uuacugacaa gggaucucaa uugcguggcu ucuggugacc uuuguguaug a               591


<210>  4462
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4462
augaccggcg acugcaugcc cgugcuggug cugauggccg ccgugcugac cgugaccggc       60

gccgugcccg uggccagacu gagaggcgcc cugcccgacg ccagaggcug ccacaucgcc      120

caguucaaga gccugagccc ccaggagcug caggccuuca agagagccaa ggacgcccug      180

gaggagagcc ugcugcugaa ggacugcaag ugcagaagca gacuguuccc cagaaccugg      240

gaccugagac agcugcaggu gagagagaga cccguggccc uggaggccga gcuggcccug      300

acccugaagg ugcuggaggc caccgccgac accgaccccg cccugggcga cgugcuggac      360

cagccccugc acacccugca ccacauccug agccagcuga gagccugcau ccagccccag      420

cccaccgccg gccccagaac cagaggcaga cugcaccacu ggcugcacag acugcaggag      480

gcccccaaga aggagagccc cggcugccug gaggccagcg ugaccuucaa ccuguucaga      540

cugcugacca gagaccugaa cugcguggcc agcggcgacc ugugcgugug a               591


<210>  4463
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4463
augaccggcg acugcaugcc cgugcugguc cucauggccg cuguucugac agugacgggg       60

gccgugccug ucgcgagacu ucggggagcu cugccggaug cccgcggcug ucacaucgcc      120

caguucaaga gccucucucc ccaagagcug caggcuuuua aaagagccaa ggacgcucuu      180

gaagaguccc ugcuccugaa agauugcaag ugucggagcc gccuguuccc uagaaccugg      240

gaccuccggc agcuucaggu gcgcgaaaga cccguugccc uggaggcgga acuggcccuc      300

acacugaaag ugcuugaggc uaccgccgau acagacccug cucuggggga uguccucgac      360

caaccccugc auacccugca ccauauucuc ucccagcugc gggccugcau ccagccucag      420

ccgacagcgg gaccccgcac cagaggccgg cuucaccauu ggcugcaccg ccuccaagag      480

gccccuaaga aggaaucucc cgggugucug gaggcuagcg ugacguuuaa ccuuuucaga      540

cugcucaccc gggaucugaa uugcguugcc uccggagacc ugugugugug a               591


<210>  4464
<211>  591
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-28B__Homo_sapiens__AAI30315

<400>  4464
augacaggag acuguaugcc aguacuagua uuaauggcag caguauuaac aguaacagga       60

gcaguaccag uagcaagacu aagaggagca uuaccagacg caagaggaug ccacauagca      120

caauucaaaa gucuaucacc acaagaacua caagcauuca aaagagcaaa agacgcacua      180

gaagaaucac uauuacuaaa agacuguaaa ugcagaucaa gacuauuccc aagaacaugg      240

gaucuaagac aauuacaagu aagagaaaga ccaguagcac uagaagcaga auuagcacua      300

acauuaaaag uacuagaagc aacagcagac acagaccccg cauuaggaga cguacuagac      360

caaccauuac acacacuaca ccacauauua ucacaacuua gagcaugcau acaaccacaa      420

ccaacagcag gaccaagaac aagaggaaga cuacaccacu ggcuacacag acuacaagaa      480

gcaccaaaaa aagaaagccc aggaugccua gaagcaucag ucacauucaa ccucuucaga      540

cuacuaacaa gagacuuaaa cugcguagca uccggagacc uauguguaua a               591


<210>  4465
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-29__Homo_sapiens__Q8IU54

<400>  4465

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


<210>  4466
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-29__Homo_sapiens__AAH74985

<400>  4466
auggcugcag cuuggaccgu ggugcuggug acuuuggugc uaggcuuggc cguggcaggc       60

ccugucccca cuuccaagcc caccacaacu gggaagggcu gccacauugg cagguucaaa      120

ucucugucac cacaggagcu agcgagcuuc aagaaggcca gggacgccuu ggaagaguca      180

cucaagcuga aaaacuggag uugcagcucu ccugucuucc ccgggaauug ggaccugagg      240

cuucuccagg ugagggagcg cccuguggcc uuggaggcug agcuggcccu gacgcugaag      300

guccuggagg ccgcugcugg cccagcccug gaggacgucc uagaccagcc ccuucacacc      360

cugcaccaca uccucuccca gcuccaggcc uguauccagc cucagcccac agcagggccc      420

aggccccggg gccgccucca ccacuggcug caccggcucc aggaggcccc caaaaaggag      480

uccgcuggcu gccuggaggc aucugucacc uucaaccucu uccgccuccu cacgcgagac      540

cucaaauaug uggccgaugg gaaccugugu cugagaacgu caacccaccc ugaguccacc      600

uga                                                                    603


<210>  4467
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-29__Homo_sapiens__AAH74985

<400>  4467
auggccgccg cguggaccgu gguccuggug acccucgugc ugggccuggc cgucgccggg       60

cccgugccga cgagcaagcc caccaccacc ggcaaggggu gccacaucgg ccgcuucaag      120

ucccucagcc cccaggagcu ggccuccuuc aagaaggccc gggacgcgcu ggaggagagc      180

cucaagcuga agaacugguc cugcagcucc cccguguucc cggggaacug ggaccugcgc      240

cuccugcagg uccgggagcg ccccguggcc cuggaggccg agcucgcccu gacgcugaag      300

gugcucgagg cggccgccgg ccccgcccug gaggacgucc uggaccagcc ccuccacacc      360

cugcaccaca uccugagcca gcuccaggcc ugcauccagc cgcagcccac cgcgggcccc      420

cggccccgcg ggcggcugca ccacuggcug caccgccucc aggaggcccc gaagaaggag      480

uccgccggcu gccuggaggc cagcgugacc uucaaccugu uccggcuccu gacgcgcgac      540

cugaaguacg uggccgacgg gaaccucugc cugcggaccu ccacccaccc cgagagcacc      600

uga                                                                    603


<210>  4468
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-29__Homo_sapiens__AAH74985

<400>  4468
auggccgccg ccuggaccgu cguccucguc acccucgucc ucggccucgc cgucgccggc       60

cccgucccca ccuccaagcc caccaccacc ggcaagggcu gccacaucgg ccgcuucaag      120

ucccucuccc cccaggagcu cgccuccuuc aagaaggccc gcgacgcccu cgaggagucc      180

cucaagcuca agaacugguc cugcuccucc cccgucuucc ccggcaacug ggaccuccgc      240

cuccuccagg uccgcgagcg ccccgucgcc cucgaggccg agcucgcccu cacccucaag      300

guccucgagg ccgccgccgg ccccgcccuc gaggacgucc ucgaccagcc ccuccacacc      360

cuccaccaca uccucuccca gcuccaggcc ugcauccagc cccagcccac cgccggcccc      420

cgcccccgcg gccgccucca ccacuggcuc caccgccucc aggaggcccc caagaaggag      480

uccgccggcu gccucgaggc cuccgucacc uucaaccucu uccgccuccu cacccgcgac      540

cucaaguacg ucgccgacgg caaccucugc cuccgcaccu ccacccaccc cgaguccacc      600

uga                                                                    603


<210>  4469
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-29__Homo_sapiens__AAH74985

<400>  4469
auggccgcug cauggaccgu gguccugguu acacucgugc uuggccuggc cguagcgggg       60

cccgugccua cuagcaagcc aacgaccaca ggaaaagguu gccacaucgg cagauucaag      120

uccuugucuc cgcaggaguu agcuucauuu aaaaaggcca gggacgcacu ggaagagagu      180

cuaaaacuca agaacuggag cuguuccucu cccgucuucc cugggaauug ggaucugcgg      240

cuucugcaag ugcgcgaacg accaguugcc uuggaggcug aacucgcacu gacucugaag      300

gugcucgagg ccgcugccgg acccgcguua gaggacgucc uggaucagcc ucuucauacc      360

uugcaccaua uucugucgca gcuacaggca ugcauacaac cacagcccac agccggcccu      420

cguccaagag guaggcucca ccauuggcug caccggcuuc aggaagcucc gaaaaaggag      480

ucagccgggu gucuggaagc aagcgugacc uuuaacuugu uccgccuccu gacuagagac      540

uuaaaauacg uagcugaugg aaaucugugc cucaggacaa guacccaccc cgaguccacg      600

uga                                                                    603


<210>  4470
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-29__Homo_sapiens__AAH74985

<400>  4470
auggccgccg ccuggaccgu ggugcuggug acccuggugc ugggccuggc cguggccggc       60

cccgugccca ccagcaagcc caccaccacc ggcaagggcu gccacaucgg cagauucaag      120

agccugagcc cccaggagcu ggccagcuuc aagaaggcca gagacgcccu ggaggagagc      180

cugaagcuga agaacuggag cugcagcagc cccguguucc ccggcaacug ggaccugaga      240

cugcugcagg ugagagagag acccguggcc cuggaggccg agcuggcccu gacccugaag      300

gugcuggagg ccgccgccgg ccccgcccug gaggacgugc uggaccagcc ccugcacacc      360

cugcaccaca uccugagcca gcugcaggcc ugcauccagc cccagcccac cgccggcccc      420

agacccagag gcagacugca ccacuggcug cacagacugc aggaggcccc caagaaggag      480

agcgccggcu gccuggaggc cagcgugacc uucaaccugu ucagacugcu gaccagagac      540

cugaaguacg uggccgacgg caaccugugc cugagaacca gcacccaccc cgagagcacc      600

uga                                                                    603


<210>  4471
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-29__Homo_sapiens__AAH74985

<400>  4471
auggccgcug ccuggaccgu gguccugguu acacucgugc ugggccuugc gguggcuggg       60

cccgucccua cgagcaagcc gaccacaacc ggaaaaggcu gccacaucgg gagauucaag      120

ucccugucuc cccaggagcu cgccagcuuu aaaaaggccc gggacgcucu ggaagagucc      180

cuuaaacuga agaacugguc uuguagcucc ccuguguucc ccggaaauug ggaucuccgc      240

cugcugcaag uuagagaacg gccuguggcc cucgaggcug aacuggcccu uacacugaag      300

guccucgagg cggccgcugg ccccgcccug gaggacgugc uugaucagcc ucugcauacc      360

cuccaccaua uucugucuca gcugcaggcu ugcauccaac cgcagcccac agccgggccu      420

cgccccagag gacggcucca ccauuggcug caccgccuuc aggaagcgcc uaaaaaggag      480

agcgccggcu gucuggaggc uuccguuacc uuuaaccucu ucagacugcu uacgcgggac      540

cugaaauacg uggccgaugg caaucucugc cugcgcacca gcacacaccc cgaaucuacc      600

uga                                                                    603


<210>  4472
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-29__Homo_sapiens__AAH74985

<400>  4472
auggcagcag cauggacagu aguacuagua acacuaguau uaggacuagc aguagcagga       60

ccaguaccaa caucaaaacc aacaacaacu ggaaaaggau gucacauagg aagauucaaa      120

ucauuaucac cacaagaacu agcaaguuuc aaaaaagcaa gagacgcacu agaagaauca      180

cuaaaauuaa aaaacuggag cugcaguuca cccguauucc caggaaacug ggaucuaaga      240

cuacuacaag uaagagaacg accaguagca cuagaagcag aacuagcacu aacauuaaaa      300

guauuagaag cagcagccgg cccagccuua gaagacguau uagaccaacc acuacauaca      360

cuacaccaua uacuaucuca acuacaagca ugcauacaac cacaaccaac agcaggacca      420

agaccacgag gaagacuaca ccacugguua cacagacuac aagaagcacc aaaaaaagaa      480

ucagcaggau guuuagaagc aucagucaca uucaaccuau ucagacuacu aacaagagac      540

cuaaaauacg uagcagacgg aaacuuaugc cuaagaaccu caacacaucc cgaaucaaca      600

uaa                                                                    603


<210>  4473
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__P60568

<400>  4473

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  4474
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__AAA98792

<400>  4474
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cacaaacagu       60

gcaccuacuu caaguucuac aaagaaaaca cagcuacaac uggagcauuu acugcuggau      120

uuacagauga uuuugaaugg aauuaauaau uacaagaauc ccaaacucac caggaugcuc      180

acauuuaagu uuuacaugcc caagaaggcc acagaacuga aacaucuuca gugucuagaa      240

gaagaacuca aaccucugga ggaagugcua aauuuagcuc aaagcaaaaa cuuucacuua      300

agacccaggg acuuaaucag caauaucaac guaauaguuc uggaacuaaa gggaucugaa      360

acaacauuca ugugugaaua ugcugaugag acagcaacca uuguagaauu ucugaacaga      420

uggauuaccu uuugucaaag caucaucuca acacugacuu ga                         462


<210>  4475
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-2__Homo_sapiens__AAA98792

<400>  4475
auguaccgca ugcagcugcu cagcugcauc gcccuguccc uggcccucgu gaccaacagc       60

gcgcccaccu ccagcuccac gaagaagacc cagcugcagc uggagcaccu ccugcuggac      120

cuccagauga uccugaacgg caucaacaac uacaagaacc cgaagcugac ccggaugcuc      180

accuucaagu ucuacaugcc caagaaggcc acggagcuga agcaccucca gugccuggag      240

gaggagcuga agccccugga ggagguccuc aaccuggccc agagcaagaa cuuccaccuc      300

cgcccccggg accugaucuc caacaucaac gugaucgugc uggagcugaa ggggagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacga ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucagc acccugaccu ga                         462


<210>  4476
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-2__Homo_sapiens__AAA98792

<400>  4476
auguaccgca ugcagcuccu cuccugcauc gcccucuccc ucgcccucgu caccaacucc       60

gcccccaccu ccuccuccac caagaagacc cagcuccagc ucgagcaccu ccuccucgac      120

cuccagauga uccucaacgg caucaacaac uacaagaacc ccaagcucac ccgcaugcuc      180

accuucaagu ucuacaugcc caagaaggcc accgagcuca agcaccucca gugccucgag      240

gaggagcuca agccccucga ggagguccuc aaccucgccc aguccaagaa cuuccaccuc      300

cgcccccgcg accucaucuc caacaucaac gucaucgucc ucgagcucaa gggcuccgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucucc acccucaccu ga                         462


<210>  4477
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-2__Homo_sapiens__AAA98792

<400>  4477
auguacagaa ugcagcugcu cagcugcauc gcccuuuccc uggcuuuggu gaccaacucu       60

gcacccacau caaguagcac uaagaaaacg caauuacagc uggagcaccu acuccuggac      120

cuucagauga uucugaaugg cauaaacaau uauaagaacc cuaaauugac caggaugcuc      180

acauucaagu uuuacaugcc gaaaaaggcc acugaacuga agcaucugca gugucucgag      240

gaagaguuaa aaccacugga agagguccuu aauuuggcgc aauccaagaa cuuccaccua      300

cggccccgcg aucugaucuc uaauauuaac guuaucgugc ucgagcugaa agggucggaa      360

accacauuua ugugcgagua ugcugacgaa accgccacua uuguagaguu ccuuaaucga      420

uggaucacau uuugucaguc aauaaucagc acccugacgu ga                         462


<210>  4478
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-2__Homo_sapiens__AAA98792

<400>  4478
auguacagaa ugcagcugcu gagcugcauc gcccugagcc uggcccuggu gaccaacagc       60

gcccccacca gcagcagcac caagaagacc cagcugcagc uggagcaccu gcugcuggac      120

cugcagauga uccugaacgg caucaacaac uacaagaacc ccaagcugac cagaaugcug      180

accuucaagu ucuacaugcc caagaaggcc accgagcuga agcaccugca gugccuggag      240

gaggagcuga agccccugga ggaggugcug aaccuggccc agagcaagaa cuuccaccug      300

agacccagag accugaucag caacaucaac gugaucgugc uggagcugaa gggcagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucguggaguu ccugaacaga      420

uggaucaccu ucugccagag caucaucagc acccugaccu ga                         462


<210>  4479
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-2__Homo_sapiens__AAA98792

<400>  4479
auguacagaa ugcagcugcu cagcugcauc gcccuguccc uugcucuggu gaccaacucu       60

gcccccacaa gcuccucuac gaagaaaacc caacuccagc uggagcaccu ucugcucgac      120

cugcagauga uucugaaugg caucaacaau uauaagaacc cuaaacucac acggaugcug      180

accuucaagu uuuacaugcc gaaaaaggcg acagaacuua agcaucugca gugucucgag      240

gaggaacuga aaccccuuga agagguccug aaucucgcuc aaagcaagaa cuuccaccuc      300

cgcccuagag aucugauuuc caauaucaac guuauugugc uggagcugaa agggucugaa      360

accacauuua ugugcgagua ugccgacgaa accgccacga ucguggaguu ccuuaaucgg      420

uggaucaccu uuugucagag cauuaucucc acacugaccu ga                         462


<210>  4480
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-2__Homo_sapiens__AAA98792

<400>  4480
auguacagaa ugcaacuacu aucaugcaua gcacuaucac uagcacuagu aacaaacuca       60

gcaccaacau caucaucaac caaaaaaaca caacuacaac ucgaacaccu ccuccucgac      120

cuacaaauga uacuaaacgg aauaaacaac uacaaaaacc caaaacuaac aagaaugcua      180

acauucaaau ucuacaugcc aaaaaaagca acagaacuaa aacaccuaca augccuagaa      240

gaagaacuca aaccacuaga agaaguacua aaccucgcac aaucaaaaaa cuuccaccua      300

cgaccaagag accuaauauc aaacauaaac gucauaguac uagaacuaaa aggaucagaa      360

acaacauuca ugugcgaaua ugcagacgaa acagcaacaa uaguagaauu ccuaaacaga      420

uggauaacau ucugccaauc aauaauauca acacuaacau aa                         462


<210>  4481
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__Q0GK43

<400>  4481

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  4482
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__ABI20697

<400>  4482
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cacaaacagu       60

gcaccuacuu caaguucuac aaagaaaaca cagcuacaac uggagcauuu acugcuggau      120

uuacagauga uuuugaaugg aauuaauaau uacaagaauc ccaaacucac caggaugcuc      180

acauuuaagu uuuacaugcc caagaaggcc acagaacuga aacaucuuca gugucuagaa      240

gaagaacuca aaccucugga ggaagugcua aauuuagcuc aaagcaaaaa cuuucacuua      300

agacccaggg acuuaaucag caauaucaac guaauaguuc uggaacuaaa gggaucugaa      360

acaacauuca ugugugaaua ugcugaugag acagcaacca uuguagaauu ucugaacaga      420

uggauuaccu uuugucaaag caucaucuca acacugacuu ga                         462


<210>  4483
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-2__Homo_sapiens__ABI20697

<400>  4483
auguaccgca ugcagcugcu cagcugcauc gcccuguccc uggcccucgu gaccaacagc       60

gcgcccaccu ccagcuccac gaagaagacc cagcugcagc uggagcaccu ccugcuggac      120

cuccagauga uccugaacgg caucaacaac uacaagaacc cgaagcugac ccggaugcuc      180

accuucaagu ucuacaugcc caagaaggcc acggagcuga agcaccucca gugccuggag      240

gaggagcuga agccccugga ggagguccuc aaccuggccc agagcaagaa cuuccaccuc      300

cgcccccggg accugaucuc caacaucaac gugaucgugc uggagcugaa ggggagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacga ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucagc acccugaccu ga                         462


<210>  4484
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-2__Homo_sapiens__ABI20697

<400>  4484
auguaccgca ugcagcuccu cuccugcauc gcccucuccc ucgcccucgu caccaacucc       60

gcccccaccu ccuccuccac caagaagacc cagcuccagc ucgagcaccu ccuccucgac      120

cuccagauga uccucaacgg caucaacaac uacaagaacc ccaagcucac ccgcaugcuc      180

accuucaagu ucuacaugcc caagaaggcc accgagcuca agcaccucca gugccucgag      240

gaggagcuca agccccucga ggagguccuc aaccucgccc aguccaagaa cuuccaccuc      300

cgcccccgcg accucaucuc caacaucaac gucaucgucc ucgagcucaa gggcuccgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucucc acccucaccu ga                         462


<210>  4485
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-2__Homo_sapiens__ABI20697

<400>  4485
auguacagaa ugcagcugcu cagcugcauc gcccuuuccc uggcuuuggu gaccaacucu       60

gcacccacau caaguagcac uaagaaaacg caauuacagc uggagcaccu acuccuggac      120

cuucagauga uucugaaugg cauaaacaau uauaagaacc cuaaauugac caggaugcuc      180

acauucaagu uuuacaugcc gaaaaaggcc acugaacuga agcaucugca gugucucgag      240

gaagaguuaa aaccacugga agagguccuu aauuuggcgc aauccaagaa cuuccaccua      300

cggccccgcg aucugaucuc uaauauuaac guuaucgugc ucgagcugaa agggucggaa      360

accacauuua ugugcgagua ugcugacgaa accgccacua uuguagaguu ccuuaaucga      420

uggaucacau uuugucaguc aauaaucagc acccugacgu ga                         462


<210>  4486
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-2__Homo_sapiens__ABI20697

<400>  4486
auguacagaa ugcagcugcu gagcugcauc gcccugagcc uggcccuggu gaccaacagc       60

gcccccacca gcagcagcac caagaagacc cagcugcagc uggagcaccu gcugcuggac      120

cugcagauga uccugaacgg caucaacaac uacaagaacc ccaagcugac cagaaugcug      180

accuucaagu ucuacaugcc caagaaggcc accgagcuga agcaccugca gugccuggag      240

gaggagcuga agccccugga ggaggugcug aaccuggccc agagcaagaa cuuccaccug      300

agacccagag accugaucag caacaucaac gugaucgugc uggagcugaa gggcagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucguggaguu ccugaacaga      420

uggaucaccu ucugccagag caucaucagc acccugaccu ga                         462


<210>  4487
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-2__Homo_sapiens__ABI20697

<400>  4487
auguacagaa ugcagcugcu cagcugcauc gcccuguccc uugcucuggu gaccaacucu       60

gcccccacaa gcuccucuac gaagaaaacc caacuccagc uggagcaccu ucugcucgac      120

cugcagauga uucugaaugg caucaacaau uauaagaacc cuaaacucac acggaugcug      180

accuucaagu uuuacaugcc gaaaaaggcg acagaacuua agcaucugca gugucucgag      240

gaggaacuga aaccccuuga agagguccug aaucucgcuc aaagcaagaa cuuccaccuc      300

cgcccuagag aucugauuuc caauaucaac guuauugugc uggagcugaa agggucugaa      360

accacauuua ugugcgagua ugccgacgaa accgccacga ucguggaguu ccuuaaucgg      420

uggaucaccu uuugucagag cauuaucucc acacugaccu ga                         462


<210>  4488
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-2__Homo_sapiens__ABI20697

<400>  4488
auguacagaa ugcaacuccu aucaugcaua gcacucucac uagcacucgu aacaaacuca       60

gcaccaacau caucaucaac aaaaaaaaca caacuccaac uagaacaccu acuacuagac      120

cuacaaauga uacuaaacgg aauaaacaac uacaaaaacc caaaacuaac aagaaugcua      180

accuucaaau ucuacaugcc aaaaaaagca acagaacuaa aacaccucca augccuagaa      240

gaagaacuca aaccacuaga agaaguacua aaccuagcac aaucaaaaaa cuuccaccua      300

agaccaagag accuaauauc aaacauaaac gucauaguac ucgaacuaaa aggaucagaa      360

acaacauuca ugugcgaaua cgccgacgaa acagcaacaa uaguagaauu ccuaaacaga      420

uggauaacau ucugccaauc aauaauauca acacuaacau aa                         462


<210>  4489
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__Q13169

<400>  4489

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Lys Lys 
            20                  25                  30          


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
        35                  40                  45              


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
    50                  55                  60                  


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys Gln Leu Gln 
65                  70                  75                  80  


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala 
                85                  90                  95      


Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
            100                 105                 110         


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
        115                 120                 125             


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
    130                 135                 140                 


Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150                 155     


<210>  4490
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__AAA70092

<400>  4490
auguacagga ugcaacuccu gucuugcauu gcacuaauuc uugcacuugu cacaaacagu       60

gcaccuacuu caaguucgac aaagaaaaca aagaaaacac agcuacaacu ggagcauuua      120

cugcuggauu uacagaugau uuugaaugga auuaauaauu acaagaaucc caaacucacc      180

aggaugcuca cauuuaaguu uuacaugccc aagaaggcca cagaacugaa acagcuucag      240

ugucuagaag aagaacucaa accucuggag gaagugcuga auuuagcuca aagcaaaaac      300

uuucacuuaa gacccaggga cuuaaucagc aauaucaacg uaauaguucu ggaacuaaag      360

ggaucugaaa caacauucau gugugaauau gcagaugaga cagcaaccau uguagaauuu      420

cugaacagau ggauuaccuu uugucaaagc aucaucucaa cacuaacuug a               471


<210>  4491
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-2__Homo_sapiens__AAA70092

<400>  4491
auguaccgca ugcagcugcu cagcugcauc gcccugaucc uggcccucgu gaccaacucc       60

gcgcccacca gcuccagcac gaagaagacc aagaagaccc agcugcagcu ggagcaccuc      120

cugcuggacc uccagaugau ccugaacggc aucaacaacu acaagaaccc gaagcugacc      180

cggaugcuca cguucaaguu cuacaugccc aagaaggcca ccgagcugaa gcagcugcag      240

ugccucgagg aggagcugaa gccccuggag gagguccuca accuggccca guccaagaac      300

uuccaccucc gcccccggga ccugaucagc aacaucaacg ugaucgugcu ggagcugaag      360

ggguccgaga ccaccuucau gugcgaguac gccgacgaga cggccaccau cgucgaguuc      420

cucaaccgcu ggaucaccuu cugccagagc aucaucucca cccugacgug a               471


<210>  4492
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-2__Homo_sapiens__AAA70092

<400>  4492
auguaccgca ugcagcuccu cuccugcauc gcccucaucc ucgcccucgu caccaacucc       60

gcccccaccu ccuccuccac caagaagacc aagaagaccc agcuccagcu cgagcaccuc      120

cuccucgacc uccagaugau ccucaacggc aucaacaacu acaagaaccc caagcucacc      180

cgcaugcuca ccuucaaguu cuacaugccc aagaaggcca ccgagcucaa gcagcuccag      240

ugccucgagg aggagcucaa gccccucgag gagguccuca accucgccca guccaagaac      300

uuccaccucc gcccccgcga ccucaucucc aacaucaacg ucaucguccu cgagcucaag      360

ggcuccgaga ccaccuucau gugcgaguac gccgacgaga ccgccaccau cgucgaguuc      420

cucaaccgcu ggaucaccuu cugccagucc aucaucucca cccucaccug a               471


<210>  4493
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-2__Homo_sapiens__AAA70092

<400>  4493
auguacagaa ugcagcugcu cagcugcauc gcccuuauuc uggcuuuggu gaccaacucc       60

gcacccacau cuucaaguac uaagaaaacg aagaaaaccc aauuacagcu ggagcaccua      120

cuccuggacc uucagaugau acugaauggc aucaacaauu auaagaaccc uaaauugaca      180

aggaugcuca cuuucaaguu uuacaugcca aagaaagcca ccgaacugaa gcagcugcaa      240

ugucucgagg aagaguuaaa accgcuggaa gagguccuua auuuggcgca gagcaagaac      300

uuccaucugc ggccccgcga ucuaauuucc aauaucaacg uuauugugcu cgagcugaaa      360

gggucugaaa caaccuuuau gugcgaguau gcugacgaaa cugccacaau cguagaguuc      420

cuuaaucgau ggauaaccuu uugucagucg aucauuucaa cgcugacuug a               471


<210>  4494
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-2__Homo_sapiens__AAA70092

<400>  4494
auguacagaa ugcagcugcu gagcugcauc gcccugaucc uggcccuggu gaccaacagc       60

gcccccacca gcagcagcac caagaagacc aagaagaccc agcugcagcu ggagcaccug      120

cugcuggacc ugcagaugau ccugaacggc aucaacaacu acaagaaccc caagcugacc      180

agaaugcuga ccuucaaguu cuacaugccc aagaaggcca ccgagcugaa gcagcugcag      240

ugccuggagg aggagcugaa gccccuggag gaggugcuga accuggccca gagcaagaac      300

uuccaccuga gacccagaga ccugaucagc aacaucaacg ugaucgugcu ggagcugaag      360

ggcagcgaga ccaccuucau gugcgaguac gccgacgaga ccgccaccau cguggaguuc      420

cugaacagau ggaucaccuu cugccagagc aucaucagca cccugaccug a               471


<210>  4495
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-2__Homo_sapiens__AAA70092

<400>  4495
auguacagaa ugcagcugcu cagcugcauc gcccugauuc uugcucuggu gaccaacucc       60

gcccccacau cuagcuccac gaagaaaacc aagaaaacac aacuccagcu ggagcaccuu      120

cugcucgacc ugcagaugau ccugaauggc auuaacaauu auaagaaccc uaaacucacc      180

cggaugcuga cauucaaguu uuacaugccg aagaaagcga ccgaacuuaa gcagcugcaa      240

ugucucgagg aggaacugaa accccuugaa gagguccuga aucucgcuca gucuaagaac      300

uuccaucugc gcccuagaga ucugaucagc aauauuaacg uuaucgugcu cgagcugaaa      360

ggguccgaaa caaccuuuau gugcgaguau gccgacgaaa cggccaccau cguggaguuc      420

cuuaaucggu ggauuacauu uugucagucu aucauuagca cccugacaug a               471


<210>  4496
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-2__Homo_sapiens__AAA70092

<400>  4496
auguacagaa ugcaacuacu aucaugcaua gcacuaauac uagcacuagu aaccaacuca       60

gcaccaacau caucaucaac aaaaaaaacc aaaaaaacac aacuacaacu agaacaccua      120

cuacuagacc uacaaaugau acucaacgga auaaacaacu acaaaaaccc caaacuaaca      180

agaaugcuaa cauucaaauu cuacaugcca aaaaaagcaa cagaacuaaa acaacuacaa      240

ugcuuagaag aagaacuaaa accacuagaa gaaguacuaa accuagccca aucaaaaaac      300

uuccaccuaa gaccaagaga ccucauauca aacauaaacg uaauaguacu agaacuaaaa      360

ggaucagaaa caacauucau gugcgaauac gcagacgaaa ccgcaacaau aguagaauuc      420

cuaaacagau ggauaacauu cugccaauca auaauaucaa cauuaacaua a               471


<210>  4497
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__Q6NZ91

<400>  4497

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Leu Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  4498
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__AAH66256

<400>  4498
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cacaaacagu       60

gcacuuacuu caaguucuac aaagaaaaca cagcuacaac uggagcauuu acugcuggau      120

uuacagauga uuuugaaugg aauuaauaau uacaagaauc ccaaacucac caggaugcuc      180

acauuuaagu uuuacaugcc caagaaggcc acagaacuga aacaucuuca gugucuagaa      240

gaagaacuca aaccucugga ggaagugcua aauuuagcuc aaagcaaaaa cuuucacuua      300

agacccaggg acuuaaucag caauaucaac guaauaguuc uggaacuaaa gggaucugaa      360

acaacauuca ugugugaaua ugcugaugag acagcaacca uuguagaauu ucugaacaga      420

uggauuaccu uuugucaaag caucaucuca acacugacuu ga                         462


<210>  4499
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-2__Homo_sapiens__AAH66256

<400>  4499
auguaccgca ugcagcugcu cagcugcauc gcccuguccc uggcccucgu gaccaacagc       60

gcgcugaccu ccagcuccac gaagaagacc cagcugcagc ucgagcaccu ccugcuggac      120

cugcagauga uccugaacgg caucaacaac uacaagaacc ccaagcucac ccggaugcug      180

accuucaagu ucuacaugcc gaagaaggcc acggagcuga agcaccucca gugccuggag      240

gaggagcuga agccccucga ggagguccug aaccuggccc agagcaagaa cuuccaccuc      300

cgcccccggg accugaucuc caacaucaac gugaucgugc uggagcucaa ggggagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacga ucgucgaguu ccugaaccgc      420

uggaucaccu ucugccaguc caucaucagc acccugaccu ga                         462


<210>  4500
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-2__Homo_sapiens__AAH66256

<400>  4500
auguaccgca ugcagcuccu cuccugcauc gcccucuccc ucgcccucgu caccaacucc       60

gcccucaccu ccuccuccac caagaagacc cagcuccagc ucgagcaccu ccuccucgac      120

cuccagauga uccucaacgg caucaacaac uacaagaacc ccaagcucac ccgcaugcuc      180

accuucaagu ucuacaugcc caagaaggcc accgagcuca agcaccucca gugccucgag      240

gaggagcuca agccccucga ggagguccuc aaccucgccc aguccaagaa cuuccaccuc      300

cgcccccgcg accucaucuc caacaucaac gucaucgucc ucgagcucaa gggcuccgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucucc acccucaccu ga                         462


<210>  4501
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-2__Homo_sapiens__AAH66256

<400>  4501
auguacagaa ugcagcugcu cagcugcauc gcccuuuccc uggcuuuggu gaccaacucu       60

gcauuaacau caaguagcac uaagaaaacg caacugcagc uagagcaccu ccugcuugac      120

cugcagauga uuuugaaugg cauaaacaau uauaagaacc ccaaacucac caggaugcug      180

acauucaagu uuuacaugcc uaaaaaggcc acugaacuga agcaucucca guguuuagag      240

gaggaacuga aaccacuuga agaggucuug aaucuggcgc aauccaagaa cuuccaccua      300

cggccgcgcg aucucaucuc uaauauuaac guuaucgugc uggagcuuaa agggucggaa      360

accacauuua ugugcgagua ugcugacgaa accgccacua uuguagaguu ccugaaucga      420

uggaucacau uuugucaguc aauaaucagc accuugacgu ga                         462


<210>  4502
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-2__Homo_sapiens__AAH66256

<400>  4502
auguacagaa ugcagcugcu gagcugcauc gcccugagcc uggcccuggu gaccaacagc       60

gcccugacca gcagcagcac caagaagacc cagcugcagc uggagcaccu gcugcuggac      120

cugcagauga uccugaacgg caucaacaac uacaagaacc ccaagcugac cagaaugcug      180

accuucaagu ucuacaugcc caagaaggcc accgagcuga agcaccugca gugccuggag      240

gaggagcuga agccccugga ggaggugcug aaccuggccc agagcaagaa cuuccaccug      300

agacccagag accugaucag caacaucaac gugaucgugc uggagcugaa gggcagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucguggaguu ccugaacaga      420

uggaucaccu ucugccagag caucaucagc acccugaccu ga                         462


<210>  4503
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-2__Homo_sapiens__AAH66256

<400>  4503
auguacagaa ugcagcugcu cagcugcauc gcccuguccc uugcucuggu gaccaacucu       60

gcccucacaa gcuccucuac gaagaaaacc caacugcagc uugagcaccu ccugcuggac      120

cugcagauga uucucaaugg caucaacaau uauaagaacc ccaaacugac acggaugcuu      180

accuucaagu uuuacaugcc uaaaaaggcg acagaacuga agcaccucca gugucuggag      240

gaggaacuua aaccgcugga agagguccuc aaucuggcuc aaagcaagaa cuuccaucug      300

cgccccagag aucucauuuc caauaucaac guuauugugc uggagcuuaa agggucugaa      360

accacauuua ugugcgagua ugccgacgaa accgccacga ucguggaguu ccugaaucgg      420

uggaucaccu uuugucagag cauuaucucc acacucaccu ga                         462


<210>  4504
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-2__Homo_sapiens__AAH66256

<400>  4504
auguaccgaa ugcaacuacu aucaugcaua gcacuauccc uagccuuagu aacaaacuca       60

gcacuaacau cauccuccac aaaaaaaaca caacuacaac uagaacaccu acuccuagac      120

cuacaaauga uacuaaacgg aauaaacaac uacaaaaacc caaaacucac aagaaugcua      180

acauucaaau ucuacaugcc aaaaaaagca acagaacuaa aacaccuaca augccuagaa      240

gaagaacuaa aaccacuaga agaaguacua aaccuagcac aaucaaaaaa cuuccaccua      300

agaccaagag accuaauauc aaacauaaac guaauaguac uagaacuaaa aggaucagaa      360

acaacauuca ugugcgaaua cgcagacgaa acagcaacaa uaguagaauu ccuaaaccga      420

uggauaacau ucugccaauc aauaauauca acacuaacau aa                         462


<210>  4505
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__Q6NZ93

<400>  4505

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Ala Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  4506
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-2__Homo_sapiens__AAH66254

<400>  4506
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cgcaaacagu       60

gcaccuacuu caaguucuac aaagaaaaca cagcuacaac uggagcauuu acugcuggau      120

uuacagauga uuuugaaugg aauuaauaau uacaagaauc ccaaacucac caggaugcuc      180

acauuuaagu uuuacaugcc caagaaggcc acagaacuga aacaucuuca gugucuagaa      240

gaagaacuca aaccucugga ggaagugcua aauuuagcuc aaagcaaaaa cuuucacuua      300

agacccaggg acuuaaucag caauaucaac guaauaguuc uggaacuaaa gggaucugaa      360

acaacauuca ugugugaaua ugcugaugag acagcaacca uuguagaauu ucugaacaga      420

uggauuaccu uuugucaaag caucaucuca acacugacuu ga                         462


<210>  4507
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-2__Homo_sapiens__AAH66254

<400>  4507
auguaccgca ugcagcugcu cagcugcauc gcccuguccc uggcccucgu ggcgaacagc       60

gcccccaccu ccagcuccac caagaagacg cagcugcagc uggagcaccu ccugcuggac      120

cuccagauga uccugaacgg caucaacaac uacaagaacc cgaagcugac ccggaugcuc      180

accuucaagu ucuacaugcc caagaaggcc accgagcuga agcaccucca gugccuggag      240

gaggagcuga agccccugga ggagguccuc aaccuggccc agagcaagaa cuuccaccuc      300

cgcccccggg accugaucuc caacaucaac gugaucgugc uggagcugaa ggggagcgag      360

acgaccuuca ugugcgagua cgccgacgag accgcgacca ucgucgaguu ccucaaccgc      420

uggaucacgu ucugccaguc caucaucagc acccugaccu ga                         462


<210>  4508
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-2__Homo_sapiens__AAH66254

<400>  4508
auguaccgca ugcagcuccu cuccugcauc gcccucuccc ucgcccucgu cgccaacucc       60

gcccccaccu ccuccuccac caagaagacc cagcuccagc ucgagcaccu ccuccucgac      120

cuccagauga uccucaacgg caucaacaac uacaagaacc ccaagcucac ccgcaugcuc      180

accuucaagu ucuacaugcc caagaaggcc accgagcuca agcaccucca gugccucgag      240

gaggagcuca agccccucga ggagguccuc aaccucgccc aguccaagaa cuuccaccuc      300

cgcccccgcg accucaucuc caacaucaac gucaucgucc ucgagcucaa gggcuccgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucgucgaguu ccucaaccgc      420

uggaucaccu ucugccaguc caucaucucc acccucaccu ga                         462


<210>  4509
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-2__Homo_sapiens__AAH66254

<400>  4509
auguacagaa ugcagcugcu cagcugcauc gcccuuuccc uggcuuuggu ggcaaacucu       60

gcccccaccu caaguagcac aaagaaaacu caauuacagc uggagcaccu acuccuggac      120

cuucagauga uucugaaugg cauaaacaau uauaagaacc cuaaauugac gaggaugcuc      180

accuucaagu uuuacaugcc gaaaaaggcg acagaacuga agcaucugca gugucucgag      240

gaagaguuaa aaccacugga agagguccuu aauuuggcuc aauccaagaa cuuccaccua      300

cggccccgcg aucugaucuc uaauauuaac guuaucgugc ucgagcugaa agggucggaa      360

acuaccuuua ugugcgagua ugccgacgaa acagcaacca uuguagaguu ccuuaaucga      420

uggaucacuu uuugucaguc aauaaucagc acacugaccu ga                         462


<210>  4510
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-2__Homo_sapiens__AAH66254

<400>  4510
auguacagaa ugcagcugcu gagcugcauc gcccugagcc uggcccuggu ggccaacagc       60

gcccccacca gcagcagcac caagaagacc cagcugcagc uggagcaccu gcugcuggac      120

cugcagauga uccugaacgg caucaacaac uacaagaacc ccaagcugac cagaaugcug      180

accuucaagu ucuacaugcc caagaaggcc accgagcuga agcaccugca gugccuggag      240

gaggagcuga agccccugga ggaggugcug aaccuggccc agagcaagaa cuuccaccug      300

agacccagag accugaucag caacaucaac gugaucgugc uggagcugaa gggcagcgag      360

accaccuuca ugugcgagua cgccgacgag accgccacca ucguggaguu ccugaacaga      420

uggaucaccu ucugccagag caucaucagc acccugaccu ga                         462


<210>  4511
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-2__Homo_sapiens__AAH66254

<400>  4511
auguacagaa ugcagcugcu cagcugcauc gcccuguccc uugcucuggu ggccaacucu       60

gcgcccacca gcuccucuac aaagaaaacg caacuccagc uggagcaccu ucugcucgac      120

cugcagauga uucugaaugg caucaacaau uauaagaacc cuaaacucac ccggaugcug      180

acauucaagu uuuacaugcc gaaaaaggcu accgaacuua agcaucugca gugucucgag      240

gaggaacuga aaccccuuga agagguccug aaucucgccc aaagcaagaa cuuccaccuc      300

cgcccuagag aucugauuuc caauaucaac guuauugugc uggagcugaa agggucugaa      360

acaaccuuua ugugcgagua ugccgacgaa acagcuacca ucguggaguu ccuuaaucgg      420

uggaucacgu uuugucagag cauuaucucc acccugacau ga                         462


<210>  4512
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-2__Homo_sapiens__AAH66254

<400>  4512
auguacagaa ugcaacuacu aucaugcaua gcacucucac uagcacuagu agcaaacuca       60

gcaccaacau caucaucaac aaaaaaaaca caacuacaac uagaacaccu acuacuagac      120

cuacaaauga uccuaaacgg aauaaacaac uacaaaaacc caaaacuaac aagaaugcua      180

acauucaaau ucuacaugcc caaaaaagca acagaacuaa aacaccuaca augccuagaa      240

gaagaacuaa aaccacuaga agaaguacua aaccuagcac aauccaaaaa cuuccaccua      300

agaccaagag accuaauauc aaacauaaac guaauaguac uagaacuaaa aggaucagaa      360

acaacauuca ugugcgaaua cgcagacgaa acagccacaa uaguagaauu ccuaaacaga      420

uggauaacau ucugccaauc aauaauauca acacuaaccu aa                         462


<210>  4513
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-31__Homo_sapiens__Q6EBC2

<400>  4513

Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 
            20                  25                  30          


Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 
        35                  40                  45              


Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 
    50                  55                  60                  


Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 
65                  70                  75                  80  


Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 
                85                  90                  95      


Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 
            100                 105                 110         


Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 
        115                 120                 125             


Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 
    130                 135                 140                 


Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 
145                 150                 155                 160 


Gln Ala Thr Thr 
                


<210>  4514
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-31__Homo_sapiens__AAI32999

<400>  4514
auggccucuc acucaggccc cucgacgucu gugcucuuuc uguucugcug ccugggaggc       60

uggcuggccu cccacacguu gcccguccgu uuacuacgac caagugauga uguacagaaa      120

auagucgagg aauuacaguc ccucucgaag augcuuuuga aagaugugga ggaagagaag      180

ggcgugcucg ugucccagaa uuacacgcug ccgugucuca gcccugacgc ccagccgcca      240

aacaacaucc acagcccagc cauccgggca uaucucaaga caaucagaca gcuagacaac      300

aaaucuguua uugaugagau cauagagcac cucgacaaac ucauauuuca agaugcacca      360

gaaacaaaca uuucugugcc aacagacacc caugaaugua aacgcuucau ccugacuauu      420

ucucaacagu uuucagagug cauggaccuc gcacuaaaau cauugaccuc uggagcccaa      480

caggccacca cuuaa                                                       495


<210>  4515
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-31__Homo_sapiens__AAI32999

<400>  4515
auggccagcc acuccggccc cagcaccucc gugcuguucc ucuucugcug ccucgggggc       60

uggcuggcca gccacacccu gccgguccgc cugcugcggc ccuccgacga cgugcagaag      120

aucguggagg agcuccagag ccuguccaag augcugcuca aggacgucga ggaggagaag      180

ggggugcugg ugagccagaa cuacacgcug cccugccucu cccccgacgc gcagccgccc      240

aacaacaucc acagccccgc cauccgcgcc uaccugaaga ccauccggca gcuggacaac      300

aaguccguca ucgacgagau caucgagcac cucgacaagc ugaucuucca ggacgccccc      360

gagaccaaca ucagcgugcc gaccgacacg cacgagugca agcgcuucau ccugaccauc      420

ucccagcagu ucagcgagug cauggaccuc gcccugaagu cccugaccag cggcgcgcag      480

caggccacca cguga                                                       495


<210>  4516
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-31__Homo_sapiens__AAI32999

<400>  4516
auggccuccc acuccggccc cuccaccucc guccucuucc ucuucugcug ccucggcggc       60

uggcucgccu cccacacccu ccccguccgc cuccuccgcc ccuccgacga cguccagaag      120

aucgucgagg agcuccaguc ccucuccaag augcuccuca aggacgucga ggaggagaag      180

ggcguccucg ucucccagaa cuacacccuc cccugccucu cccccgacgc ccagcccccc      240

aacaacaucc acucccccgc cauccgcgcc uaccucaaga ccauccgcca gcucgacaac      300

aaguccguca ucgacgagau caucgagcac cucgacaagc ucaucuucca ggacgccccc      360

gagaccaaca ucuccguccc caccgacacc cacgagugca agcgcuucau ccucaccauc      420

ucccagcagu ucuccgagug cauggaccuc gcccucaagu cccucaccuc cggcgcccag      480

caggccacca ccuga                                                       495


<210>  4517
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-31__Homo_sapiens__AAI32999

<400>  4517
auggccagcc acuccggccc cucuaccuca gugcuguucc ucuuuugcug ucuuggggga       60

uggcuggcua gucauacauu gccugucaga uuacugaggc caagcgacga uguucagaag      120

aucguggagg aacuacaauc ccucucuaaa augcugcuua aggacguaga ggaagagaaa      180

ggugugcugg ucucgcagaa cuacacuuug ccgugccucu cacccgaugc acagccucca      240

aauaacauuc acagccccgc cauacgggcg uaucugaaga cgauccgcca gcuggacaau      300

aaaaguguga uugaugaaau cauugagcau cucgacaagu uaaucuucca agaugcuccu      360

gagaccaaca uauccguucc aacagacacu cacgaaugua agcgauuuau ccugaccauu      420

ucucagcagu ucagcgagug cauggaucuu gccuugaaau cccugacauc aggcgcacag      480

caagccacca cuuga                                                       495


<210>  4518
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-31__Homo_sapiens__AAI32999

<400>  4518
auggccagcc acagcggccc cagcaccagc gugcuguucc uguucugcug ccugggcggc       60

uggcuggcca gccacacccu gcccgugaga cugcugagac ccagcgacga cgugcagaag      120

aucguggagg agcugcagag ccugagcaag augcugcuga aggacgugga ggaggagaag      180

ggcgugcugg ugagccagaa cuacacccug cccugccuga gccccgacgc ccagcccccc      240

aacaacaucc acagccccgc caucagagcc uaccugaaga ccaucagaca gcuggacaac      300

aagagcguga ucgacgagau caucgagcac cuggacaagc ugaucuucca ggacgccccc      360

gagaccaaca ucagcgugcc caccgacacc cacgagugca agagauucau ccugaccauc      420

agccagcagu ucagcgagug cauggaccug gcccugaaga gccugaccag cggcgcccag      480

caggccacca ccuga                                                       495


<210>  4519
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-31__Homo_sapiens__AAI32999

<400>  4519
auggccagcc acuccggccc cucuaccagc gugcuguucc ucuuuugcug ucuuggggga       60

uggcuggcuu cccauacacu gccugucaga cuccugcggc cgucugacga uguucagaag      120

aucguggagg aacuucaaag ccuguccaaa augcuccuga aggacgugga ggaagagaaa      180

ggcguccugg ugucucagaa cuacacgcuc cccugccuga gcccugaugc ccagcccccu      240

aauaacauuc acucccccgc gauccgcgcu uaucuuaaga ccauuagaca gcuggacaau      300

aaaagcguua ucgaugaaau uaucgagcau cucgacaagc ugaucuucca agaugccccu      360

gagacaaaca uuucugugcc gaccgacaca cacgaaugua agcgguuuau ccuuaccauu      420

ucccagcagu ucagcgagug cauggaucug gcccucaaau cucugacauc cggggcucag      480

caagccacca cguga                                                       495


<210>  4520
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-31__Homo_sapiens__AAI32999

<400>  4520
auggcaucac acucaggacc aucaaccuca guauuauucc uauucugcug cuuaggagga       60

uggcucgcau cacacacacu accaguaaga cuacuaagac cauccgacga cguacaaaaa      120

auaguagaag aacuacaauc acuaucaaaa augcuacuca aagacguaga agaagaaaaa      180

ggaguacuag uaucacaaaa cuacacacua ccaugccuau caccagacgc acaaccacca      240

aacaacauac acuccccagc aauaagagca uacuuaaaaa caauaagaca acuagacaac      300

aaaucaguaa uagacgaaau aauagaacac cuagacaaac uaauauucca agacgcacca      360

gaaacaaaca uaucuguacc aacagacaca cacgaaugca aaagauucau acuaacaaua      420

ucacaacaau ucucagaaug uauggacuua gcacuaaaau ccuuaacauc aggagcacaa      480

caagcaacaa cauaa                                                       495


<210>  4521
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-32__Homo_sapiens__P24001

<400>  4521

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  4522
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-32__Homo_sapiens__AAH09401

<400>  4522
augugcuucc cgaagguccu cucugaugac augaagaagc ugaaggcccg aaugguaaug       60

cuccucccua cuucugcuca gggguugggg gccugggucu cagcguguga cacugaggac      120

acugugggac accugggacc cuggagggac aaggauccgg cccuuuggug ccaacucugc      180

cucucuucac agcaccaggc cauagaaaga uuuuaugaua aaaugcaaaa ugcagaauca      240

ggacguggac aggugauguc gagccuggca gagcuggagg acgacuucaa agagggcuac      300

cuggagacag uggcggcuua uuaugaggag cagcacccag agcucacucc ucuacuugaa      360

aaagaaagag auggauuacg gugccgaggc aacagauccc cugucccgga uguugaggau      420

cccgcaaccg aggagccugg ggagagcuuu ugugacaagg ucaugagaug guuccaggcc      480

augcugcagc ggcugcagac cugguggcac gggguucugg ccugggugaa ggagaaggug      540

guggcccugg uccaugcagu gcaggcccuc uggaaacagu uccagaguuu cugcugcucu      600

cugucagagc ucuucauguc cucuuuccag uccuacggag ccccacgggg ggacaaggag      660

gagcugacac cccagaagug cucugaaccc caauccucaa aauga                      705


<210>  4523
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-32__Homo_sapiens__AAH09401

<400>  4523
augugcuucc ccaaggugcu gagcgacgac augaagaagc ucaaggcccg cauggucaug       60

cugcugccga ccuccgccca gggccucggg gcguggguga gcgccugcga caccgaggac      120

accgugggcc accuggggcc cuggcgggac aaggaccccg cccuguggug ccagcucugc      180

cuguccagcc agcaccaggc caucgagcgc uucuacgaca agaugcagaa cgccgagucc      240

ggccgggggc aggucaugag cucccuggcg gagcucgagg acgacuucaa ggagggcuac      300

cuggagaccg uggccgccua cuacgaggag cagcaccccg agcugacccc gcuccuggag      360

aaggagcgcg acggccugcg gugccgcggg aaccggagcc ccgugcccga cgucgaggac      420

cccgccaccg aggagccggg cgaguccuuc ugcgacaagg ugaugcgcug guuccaggcg      480

augcuccagc ggcugcagac gugguggcac ggggugcugg ccugggucaa ggagaaggug      540

guggcccucg uccacgccgu gcaggcccug uggaagcagu uccagagcuu cugcugcucc      600

cugagcgagc uguucauguc cagcuuccag uccuacggcg cgccccgcgg ggacaaggag      660

gagcucacgc cccagaagug cagcgagccc caguccagca aguga                      705


<210>  4524
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-32__Homo_sapiens__AAH09401

<400>  4524
augugcuucc ccaagguccu cuccgacgac augaagaagc ucaaggcccg cauggucaug       60

cuccucccca ccuccgccca gggccucggc gccugggucu ccgccugcga caccgaggac      120

accgucggcc accucggccc cuggcgcgac aaggaccccg cccucuggug ccagcucugc      180

cucuccuccc agcaccaggc caucgagcgc uucuacgaca agaugcagaa cgccgagucc      240

ggccgcggcc aggucauguc cucccucgcc gagcucgagg acgacuucaa ggagggcuac      300

cucgagaccg ucgccgccua cuacgaggag cagcaccccg agcucacccc ccuccucgag      360

aaggagcgcg acggccuccg cugccgcggc aaccgcuccc ccguccccga cgucgaggac      420

cccgccaccg aggagcccgg cgaguccuuc ugcgacaagg ucaugcgcug guuccaggcc      480

augcuccagc gccuccagac cugguggcac ggcguccucg ccugggucaa ggagaagguc      540

gucgcccucg uccacgccgu ccaggcccuc uggaagcagu uccaguccuu cugcugcucc      600

cucuccgagc ucuucauguc cuccuuccag uccuacggcg ccccccgcgg cgacaaggag      660

gagcucaccc cccagaagug cuccgagccc caguccucca aguga                      705


<210>  4525
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-32__Homo_sapiens__AAH09401

<400>  4525
augugcuucc ccaaggugcu gagcgacgau augaaaaagc ucaaagccag aauggucaug       60

cuucugccua ccuccgcuca gggcuugggg gcauggguuu cugccuguga cacagaggau      120

acugugggac acuuaggucc auggagggac aaggauccgg cgcuguggug ccaacuaugu      180

cucucaaguc agcaucaggc uaucgaacgg uuuuacgaca aaaugcagaa cgccgagagc      240

ggccgcgggc aaguaauguc cucucuggca gaacuugagg augacuucaa ggaaggauau      300

cuggagacgg uggccgcuua cuaugaggaa cagcaccccg aguugacccc ucuccuggaa      360

aaggagcgag auggccugcg uugcagaggu aauaggucgc caguccccga cguggaggau      420

ccugcaacag aggaaccagg ggaaucauuu ugugacaaag uuaugcggug guuccaggcc      480

augcuccagc gcuuacaaac uugguggcau ggagugcugg cuugggucaa ggagaaagug      540

guagcccuug uucacgcggu gcaggcauug uggaagcagu uucagagcuu cugcuguagu      600

cuguccgaac uauuuauguc uagcuuccaa uccuacggcg cccccagagg cgauaaagag      660

gagcucaccc cucagaagug cucagaacca cagaguagca aguga                      705


<210>  4526
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-32__Homo_sapiens__AAH09401

<400>  4526
augugcuucc ccaaggugcu gagcgacgac augaagaagc ugaaggccag aauggugaug       60

cugcugccca ccagcgccca gggccugggc gccuggguga gcgccugcga caccgaggac      120

accgugggcc accugggccc cuggagagac aaggaccccg cccuguggug ccagcugugc      180

cugagcagcc agcaccaggc caucgagaga uucuacgaca agaugcagaa cgccgagagc      240

ggcagaggcc aggugaugag cagccuggcc gagcuggagg acgacuucaa ggagggcuac      300

cuggagaccg uggccgccua cuacgaggag cagcaccccg agcugacccc ccugcuggag      360

aaggagagag acggccugag augcagaggc aacagaagcc ccgugcccga cguggaggac      420

cccgccaccg aggagcccgg cgagagcuuc ugcgacaagg ugaugagaug guuccaggcc      480

augcugcaga gacugcagac cugguggcac ggcgugcugg ccugggugaa ggagaaggug      540

guggcccugg ugcacgccgu gcaggcccug uggaagcagu uccagagcuu cugcugcagc      600

cugagcgagc uguucaugag cagcuuccag agcuacggcg cccccagagg cgacaaggag      660

gagcugaccc cccagaagug cagcgagccc cagagcagca aguga                      705


<210>  4527
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-32__Homo_sapiens__AAH09401

<400>  4527
augugcuucc ccaaggugcu gagcgacgau augaaaaagc ucaaagccag aauggucaug       60

cugcuuccua ccuccgccca gggccugggg gccuggguuu cugcguguga cacagaggau      120

acggugggac accucggccc guggcgggac aaggaucccg cucuguggug ccaacuuugu      180

cugagcuccc agcaucaggc caucgaacgc uuuuacgaca aaaugcagaa cgccgagucu      240

gggagaggac aagugaugag cucccucgcu gaacuggagg augacuucaa ggaaggcuau      300

cuggagaccg ucgccgcuua cuaugaggaa cagcacccug agcucacacc ccugcuugaa      360

aaggagcggg augggcugcg cugcagagga aaucggucuc cugugcccga cguugaggau      420

ccugccaccg aagaaccggg cgagagcuuu ugugacaaag ugaugcgcug guuccaggcg      480

augcuccaga gacugcaaac augguggcau ggcguccuug ccugggugaa ggagaaaguu      540

guggcucugg uccacgccgu gcaggcucuc uggaagcagu uucaguccuu cugcuguagc      600

cugucugaac uguuuauguc cagcuuccaa ucuuacgggg cuccccgggg agauaaagag      660

gagcucaccc cucagaagug cuccgaaccc cagagcucua aguga                      705


<210>  4528
<211>  705
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-32__Homo_sapiens__AAH09401

<400>  4528
auguguuucc caaaaguauu aucagacgau augaaaaaau uaaaagcuag aaugguaaug       60

cuauuaccaa caucagcaca aggauuagga gcauggguau cagcauguga uacagaagau      120

acaguaggac aucuaggacc auggagagau aaagauccag cauuauggug ccaauuaugu      180

cuaucaucac aacaccaagc cauagaaaga uucuaugaua aaaugcaaaa cgcagaaagu      240

ggaaggggac aaguaaugag cucacuagca gaauuagaag augacuucaa agaaggauau      300

cuagaaacag uagccgcaua cuaugaagaa caacauccag aacuaacacc auuacuagaa      360

aaagaaagag auggauuaag augucgagga aauagaagcc caguaccaga cguagaagau      420

ccagcaacag aagaaccagg agaaagcuuu ugcgauaaag uuaugcgaug guuucaagca      480

auguuacaaa gacuacaaac cugguggcau ggcguucucg cauggguaaa agaaaaagua      540

guagcacuag uacacgcagu acaagcacua uggaaacaau uucaaucauu cuguugcuca      600

uuaagcgaau uauucaugag caguuuccaa agcuauggag caccaagagg agauaaagaa      660

gaauuaacac cacaaaaaug cucagaacca caaucaagca aauaa                      705


<210>  4529
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-33__Homo_sapiens__O95760

<400>  4529

Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 


<210>  4530
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-33__Homo_sapiens__AAH47085

<400>  4530
augaagccua aaaugaagua uucaaccaac aaaauuucca cagcaaagug gaagaacaca       60

gcaagcaaag ccuuguguuu caagcuggga aaaucccaac agaaggccaa agaaguuugc      120

cccauguacu uuaugaagcu ccgcucuggc cuuaugauaa aaaaggaggc cuguuacuuu      180

aggagagaaa ccaccaaaag gccuucacug aaaacaggua gaaagcacaa aagacaucug      240

guacucgcug ccugucaaca gcagucuacu guggagugcu uugccuuugg uauaucaggg      300

guccagaaau auacuagagc acuucaugau ucaaguauca caggaauuuc accuauuaca      360

gaguaucuug cuucucuaag cacauacaau gaucaaucca uuacuuuugc uuuggaggau      420

gaaaguuaug agauauaugu ugaagacuug aaaaaagaug aaaagaaaga uaagguguua      480

cugaguuacu augagucuca acaccccuca aaugaaucag gugacggugu ugaugguaag      540

auguuaaugg uaacccugag uccuacaaaa gacuucuggu ugcaugccaa caacaaggaa      600

cacucugugg agcuccauaa gugugaaaaa ccacugccag accaggccuu cuuuguccuu      660

cauaauaugc acuccaacug uguuucauuu gaaugcaaga cugauccugg aguguuuaua      720

gguguaaagg auaaucaucu ugcucugauu aaaguagacu cuucugagaa uuuguguacu      780

gaaaauaucu uguuuaagcu cucugaaacu uag                                   813


<210>  4531
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-33__Homo_sapiens__AAH47085

<400>  4531
augaagccca agaugaagua cagcaccaac aagaucucca ccgccaagug gaagaacacg       60

gccagcaagg cgcugugcuu caagcucggc aagucccagc agaaggccaa ggaggugugc      120

ccgauguacu ucaugaagcu gcgcagcggg cugaugauca agaaggaggc cugcuacuuc      180

cggcgcgaga ccaccaagcg gcccucccuc aagaccggcc gcaagcacaa gcggcaccug      240

guccuggccg ccugccagca gcagagcacg guggagugcu ucgcguucgg gaucuccggc      300

gugcagaagu acacccgcgc ccuccacgac agcuccauca ccgggaucag ccccaucacc      360

gaguaccugg ccucccugag cacguacaac gaccagucca ucaccuucgc ccucgaggac      420

gagagcuacg agaucuacgu cgaggaccug aagaaggacg agaagaagga caaggugcug      480

cucuccuacu acgagagcca gcaccccucc aacgagagcg gcgacggcgu ggacgggaag      540

augcugaugg ucacccuguc cccgaccaag gacuucuggc uccacgcgaa caacaaggag      600

cacagcgugg agcugcacaa gugcgagaag ccccugcccg accaggccuu cuucgugcuc      660

cacaacaugc acagcaacug cgucuccuuc gagugcaaga cggaccccgg cguguucauc      720

ggggugaagg acaaccaccu ggcccugauc aaggucgaca gcuccgagaa ccucugcacc      780

gagaacaucc uguucaagcu gagcgagacc uga                                   813


<210>  4532
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-33__Homo_sapiens__AAH47085

<400>  4532
augaagccca agaugaagua cuccaccaac aagaucucca ccgccaagug gaagaacacc       60

gccuccaagg cccucugcuu caagcucggc aagucccagc agaaggccaa ggaggucugc      120

cccauguacu ucaugaagcu ccgcuccggc cucaugauca agaaggaggc cugcuacuuc      180

cgccgcgaga ccaccaagcg ccccucccuc aagaccggcc gcaagcacaa gcgccaccuc      240

guccucgccg ccugccagca gcaguccacc gucgagugcu ucgccuucgg caucuccggc      300

guccagaagu acacccgcgc ccuccacgac uccuccauca ccggcaucuc ccccaucacc      360

gaguaccucg ccucccucuc caccuacaac gaccagucca ucaccuucgc ccucgaggac      420

gaguccuacg agaucuacgu cgaggaccuc aagaaggacg agaagaagga caagguccuc      480

cucuccuacu acgaguccca gcaccccucc aacgaguccg gcgacggcgu cgacggcaag      540

augcucaugg ucacccucuc ccccaccaag gacuucuggc uccacgccaa caacaaggag      600

cacuccgucg agcuccacaa gugcgagaag ccccuccccg accaggccuu cuucguccuc      660

cacaacaugc acuccaacug cgucuccuuc gagugcaaga ccgaccccgg cgucuucauc      720

ggcgucaagg acaaccaccu cgcccucauc aaggucgacu ccuccgagaa ccucugcacc      780

gagaacaucc ucuucaagcu cuccgagacc uga                                   813


<210>  4533
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-33__Homo_sapiens__AAH47085

<400>  4533
augaagccca aaaugaagua cagcaccaac aaaaucucca cagccaagug gaaaaauacu       60

gcuucuaagg cacugugcuu caagcucggc aaaucacagc aaaaggccaa agaggugugu      120

ccuauguauu uuaugaaguu gagaaguggg cugaugauua aaaaggaagc gugcuacuuc      180

aggcgggaga cgaccaagcg cccaagccuu aaaacaggac gaaagcacaa acgucauuua      240

guccuggcug ccugucagca gcaguccacu guugaaugcu uugcauucgg uauaucuggc      300

gugcaaaagu auaccagagc ccuacacgac ucgucaauca cagggauuag cccgaucacc      360

gaguaccucg cuagucuguc cacuuauaac gaucagucua uuacauuugc acuugaagac      420

gagagcuacg agaucuaugu agaagaucug aaaaaggacg agaaaaagga uaagguguug      480

cucuccuacu acgaaucaca gcaucccagu aaugagagcg gagacggcgu cgaugguaaa      540

augcugaugg ugacccuguc uccuacgaag gacuucuggc uccacgccaa caauaaagag      600

cauuccguug aauuacacaa gugugagaaa ccacugcccg aucaggccuu uuucgugcuu      660

cacaacaugc auucaaauug cgucagcuuu gaauguaaga cugacccugg gguguucaua      720

ggaguaaagg auaaccacuu ggcucugauc aaaguugaca guucugagaa ucuaugcacc      780

gaaaacauuc ucuuuaagcu guccgagaca uga                                   813


<210>  4534
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-33__Homo_sapiens__AAH47085

<400>  4534
augaagccca agaugaagua cagcaccaac aagaucagca ccgccaagug gaagaacacc       60

gccagcaagg cccugugcuu caagcugggc aagagccagc agaaggccaa ggaggugugc      120

cccauguacu ucaugaagcu gagaagcggc cugaugauca agaaggaggc cugcuacuuc      180

agaagagaga ccaccaagag acccagccug aagaccggca gaaagcacaa gagacaccug      240

gugcuggccg ccugccagca gcagagcacc guggagugcu ucgccuucgg caucagcggc      300

gugcagaagu acaccagagc ccugcacgac agcagcauca ccggcaucag ccccaucacc      360

gaguaccugg ccagccugag caccuacaac gaccagagca ucaccuucgc ccuggaggac      420

gagagcuacg agaucuacgu ggaggaccug aagaaggacg agaagaagga caaggugcug      480

cugagcuacu acgagagcca gcaccccagc aacgagagcg gcgacggcgu ggacggcaag      540

augcugaugg ugacccugag ccccaccaag gacuucuggc ugcacgccaa caacaaggag      600

cacagcgugg agcugcacaa gugcgagaag ccccugcccg accaggccuu cuucgugcug      660

cacaacaugc acagcaacug cgugagcuuc gagugcaaga ccgaccccgg cguguucauc      720

ggcgugaagg acaaccaccu ggcccugauc aagguggaca gcagcgagaa ccugugcacc      780

gagaacaucc uguucaagcu gagcgagacc uga                                   813


<210>  4535
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-33__Homo_sapiens__AAH47085

<400>  4535
augaagccca aaaugaagua cagcaccaac aaaaucucca cagccaagug gaaaaauacg       60

gcuucuaagg cccugugcuu caagcucggc aaaagccagc aaaaggcgaa agaggugugu      120

ccuauguauu uuaugaagcu gagauccggg cuuaugauua aaaaggaggc uugcuacuuc      180

cggcgcgaaa ccacaaagag accgucucug aaaaccggac ggaagcacaa acgccaucuc      240

guccuggccg ccugucagca gcagagcaca guugaaugcu uugcuuucgg caucuccggg      300

gugcaaaagu auaccagagc ccuucacgac ucuagcauua caggaaucuc ccccauuacc      360

gaguaccugg cuagccucuc uacguauaac gaucagucca ucaccuuugc ccuggaagac      420

gagagcuacg agaucuaugu ggaagaucug aaaaaggacg agaaaaagga uaagguccuc      480

cugucuuacu acgaauccca gcauccuagc aaugagucug gcgacggggu ggauggaaaa      540

augcuuaugg uuacacuguc ccccaccaag gacuucuggc uccacgcgaa caauaaagag      600

cauagcgugg aacugcacaa gugugagaaa ccucuucccg aucaggccuu uuucguccug      660

cacaacaugc auuccaauug cgugucuuuu gaauguaaga cagacccugg cguuuucauu      720

ggcgugaagg auaaccaccu cgcucugauc aaagucgaca gcuccgagaa ucugugcacc      780

gaaaacauuc ucuuuaagcu gagcgagacg uga                                   813


<210>  4536
<211>  813
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-33__Homo_sapiens__AAH47085

<400>  4536
augaaaccaa aaaugaaaua cucaacaaac aaaauaucaa cagcaaaaug gaaaaacaca       60

gcaucaaaag cacuaugcuu caaauuagga aaaucacaac aaaaagcaaa agaagucugc      120

ccaauguauu ucaugaaacu aagaucagga cuaaugauaa aaaaagaagc uugcuauuuc      180

agaagagaaa caacaaaaag accaucacua aaaacaggaa gaaaacacaa acgacaccua      240

guacuagcag ccugccaaca acaauccaca guagaaugcu ucgcauucgg aauaucaggc      300

guacaaaaau acacaagagc acuccacgac ucauccauaa caggaauauc accaaucaca      360

gaauaccuag caucccuauc aacauacaac gaucaaucua uaacauucgc acucgaagac      420

gaaucauacg aaauauacgu agaagaccua aaaaaagacg aaaaaaaaga caaaguauua      480

uuaagcuacu acgaaagcca acacccauca aacgaaucag gagacggagu agacggaaaa      540

augcuaaugg uaacauuauc accaacaaaa gauuucuggu uacaugcaaa caacaaagaa      600

cacucagucg aauuacacaa augcgaaaaa ccacuaccag accaagcauu cuucguauua      660

cacaacaugc acucaaacug cguaucauuc gaaugcaaaa cagacccagg aguauucaua      720

ggaguaaaag auaaccacuu agcauuaaua aaaguagacu caucagaaaa ccuaugcaca      780

gaaaacauac uauucaaauu aucagaaaca uaa                                   813


<210>  4537
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-37__Homo_sapiens__Q9NZH6

<400>  4537

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Ser Pro Lys Val Lys Asn Leu Asn Pro Lys Lys Phe Ser Ile His Asp 
    50                  55                  60                  


Gln Asp His Lys Val Leu Val Leu Asp Ser Gly Asn Leu Ile Ala Val 
65                  70                  75                  80  


Pro Asp Lys Asn Tyr Ile Arg Pro Glu Ile Phe Phe Ala Leu Ala Ser 
                85                  90                  95      


Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile Leu Leu Gly 
            100                 105                 110         


Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp Lys Gly Gln 
        115                 120                 125             


Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met Lys Leu Ala 
    130                 135                 140                 


Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr Arg Ala Gln 
145                 150                 155                 160 


Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro Gly Trp Phe 
                165                 170                 175     


Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val Thr Asp Lys 
            180                 185                 190         


Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro Val Cys Lys 
        195                 200                 205             


Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
    210                 215             


<210>  4538
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-37__Homo_sapiens__AAF69252

<400>  4538
auguccuuug ugggggagaa cucaggagug aaaaugggcu cugaggacug ggaaaaagau       60

gaaccccagu gcugcuuaga agacccggcu ggaagccccc uggaaccagg cccaagccuc      120

cccaccauga auuuuguuca cacaagucca aaggugaaga acuuaaaccc gaagaaauuc      180

agcauucaug accaggauca caaaguacug guccuggacu cugggaaucu cauagcaguu      240

ccagauaaaa acuacauacg cccagagauc uucuuugcau uagccucauc cuugagcuca      300

gccucugcgg agaaaggaag uccgauucuc cugggggucu cuaaagggga guuuugucuc      360

uacugugaca aggauaaagg acaaagucau ccaucccuuc agcugaagaa ggagaaacug      420

augaagcugg cugcccaaaa ggaaucagca cgccggcccu ucaucuuuua uagggcucag      480

gugggcuccu ggaacaugcu ggagucggcg gcucaccccg gaugguucau cugcaccucc      540

ugcaauugua augagccugu uggggugaca gauaaauuug agaacaggaa acacauugaa      600

uuuucauuuc aaccaguuug caaagcugaa augagcccca gugaggucag cgauuag         657


<210>  4539
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-37__Homo_sapiens__AAF69252

<400>  4539
augagcuucg ugggcgagaa cuccgggguc aagaugggca gcgaggacug ggagaaggac       60

gagccccagu gcugccugga ggacccggcc gggagccccc ucgagcccgg ccccucccug      120

ccgaccauga acuucgugca caccuccccc aaggugaaga accugaaccc caagaaguuc      180

agcauccacg accaggacca caagguccuc gugcuggacu ccgggaaccu gaucgccgug      240

cccgacaaga acuacauccg cccggagauc uucuucgcgc ucgccagcuc ccugagcucc      300

gccagcgccg agaagggcuc ccccauccug cucggcguca gcaaggggga guucugccug      360

uacugcgaca aggacaaggg ccagucccac cccagccugc agcucaagaa ggagaagcug      420

augaagcugg ccgcgcagaa ggaguccgcc cggcgccccu ucaucuucua ccgggcccag      480

guggggagcu ggaacaugcu cgaguccgcc gcgcacccgg gcugguucau cugcacgagc      540

ugcaacugca acgagcccgu gggggucacc gacaaguucg agaaccgcaa gcacaucgag      600

uucagcuucc agcccgugug caaggccgag auguccccca gcgagguguc cgacuga         657


<210>  4540
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-37__Homo_sapiens__AAF69252

<400>  4540
auguccuucg ucggcgagaa cuccggcguc aagaugggcu ccgaggacug ggagaaggac       60

gagccccagu gcugccucga ggaccccgcc ggcucccccc ucgagcccgg ccccucccuc      120

cccaccauga acuucgucca caccuccccc aaggucaaga accucaaccc caagaaguuc      180

uccauccacg accaggacca caagguccuc guccucgacu ccggcaaccu caucgccguc      240

cccgacaaga acuacauccg ccccgagauc uucuucgccc ucgccuccuc ccucuccucc      300

gccuccgccg agaagggcuc ccccauccuc cucggcgucu ccaagggcga guucugccuc      360

uacugcgaca aggacaaggg ccagucccac cccucccucc agcucaagaa ggagaagcuc      420

augaagcucg ccgcccagaa ggaguccgcc cgccgccccu ucaucuucua ccgcgcccag      480

gucggcuccu ggaacaugcu cgaguccgcc gcccaccccg gcugguucau cugcaccucc      540

ugcaacugca acgagcccgu cggcgucacc gacaaguucg agaaccgcaa gcacaucgag      600

uucuccuucc agcccgucug caaggccgag augucccccu ccgaggucuc cgacuga         657


<210>  4541
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-37__Homo_sapiens__AAF69252

<400>  4541
augagcuucg ugggcgagaa cuccgggguc aagaugggau cugaagacug ggagaaagau       60

gaaccccagu gcugucugga ggacccugcc gguucaccac ucgaaccggg ccccagucuu      120

ccuaccauga auuuuguuca cacaagccca aaggugaaaa accugaaucc caagaaauuc      180

uccauccaug aucaagacca caagguauug guguuagauu cugggaaccu gauugcuguc      240

ccugacaaga auuacauaag accagagauc uuuuucgcac uagccucguc acucagcagu      300

gcguccgcug agaaaggauc ucccauucug cuuggcguga gcaaggguga auuuugccug      360

uauugugaua aagacaaggg gcagucccau ccuucauugc agcucaaaaa ggagaagcug      420

augaaacugg ccgcacagaa ggaaagugcc aggcggccau ucaucuuuua ccgcgcucaa      480

guuggaagcu ggaacaugcu cgagucugca gcccacccgg gcugguucau uugcacuucc      540

uguaauugca acgagcccgu gggcgucacg gauaaauuug aaaaucgaaa gcauaucgag      600

uucucauuuc agccugugug uaaagcugaa augagcccaa gugagguauc ugacuga         657


<210>  4542
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-37__Homo_sapiens__AAF69252

<400>  4542
augagcuucg ugggcgagaa cagcggcgug aagaugggca gcgaggacug ggagaaggac       60

gagccccagu gcugccugga ggaccccgcc ggcagccccc uggagcccgg ccccagccug      120

cccaccauga acuucgugca caccagcccc aaggugaaga accugaaccc caagaaguuc      180

agcauccacg accaggacca caaggugcug gugcuggaca gcggcaaccu gaucgccgug      240

cccgacaaga acuacaucag acccgagauc uucuucgccc uggccagcag ccugagcagc      300

gccagcgccg agaagggcag ccccauccug cugggcguga gcaagggcga guucugccug      360

uacugcgaca aggacaaggg ccagagccac cccagccugc agcugaagaa ggagaagcug      420

augaagcugg ccgcccagaa ggagagcgcc agaagacccu ucaucuucua cagagcccag      480

gugggcagcu ggaacaugcu ggagagcgcc gcccaccccg gcugguucau cugcaccagc      540

ugcaacugca acgagcccgu gggcgugacc gacaaguucg agaacagaaa gcacaucgag      600

uucagcuucc agcccgugug caaggccgag augagcccca gcgaggugag cgacuga         657


<210>  4543
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-37__Homo_sapiens__AAF69252

<400>  4543
augagcuucg ugggcgagaa cuccgggguc aagaugggau cugaagacug ggagaaagau       60

gaaccccagu gcugucugga ggacccugcc ggcagcccgc ucgaacccgg gccuucccug      120

cccaccauga auuuuguuca cacaucuccu aaggugaaaa accuuaaucc caagaaauuc      180

agcauccaug aucaagacca caaggugcug guccucgauu ccggaaaccu gauugcugug      240

ccugacaaga auuacaucag accggagauc uuuuucgccc uugcgucuag ccuguccagc      300

gcuucugccg agaaaggcuc ccccauucuc cuggggguua gcaagggaga auuuugccug      360

uauugugaua aagacaaggg ccagucucau ccuucccucc agcugaaaaa ggagaaacuu      420

augaagcugg ccgcucagaa ggaaagcgcc cggcgccccu ucaucuuuua cagagcucaa      480

gugggcucuu ggaacaugcu cgaguccgcc gcgcacccug ggugguucau uugcacgagc      540

uguaauugca acgagcccgu cggagugacc gauaaauuug aaaaucggaa gcauaucgag      600

uucuccuuuc agccgguuug uaaagccgaa augucuccua gcgagguguc cgacuga         657


<210>  4544
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-37__Homo_sapiens__AAF69252

<400>  4544
augucauucg uaggagaaaa uucaggagua aaaaugggau cagaagacug ggaaaaagac       60

gaaccacaau gcugccuaga agacccugca ggcucaccac uagaaccagg accaucauua      120

ccaacaauga acuucguaca cacaucccca aaaguaaaaa accuaaaccc aaaaaaauuc      180

ucaauacacg aucaagacca caaaguacua guacuagacu caggaaaccu aauagcagua      240

ccagauaaaa acuacauaag accagaaaua uucuucgcac uagcaucauc acuaucaagc      300

gcaucagcag aaaaaggauc accaauacua cuaggaguau caaaaggaga auucugcuua      360

uacugcgaca aagacaaagg acaaucacac ccaucacuac aacuaaaaaa agaaaaauua      420

augaaacuag cagcacaaaa agaaucagca agaagaccau ucauauucua uagagcacaa      480

guaggaucau ggaacauguu agaaucagca gcccacccag gaugguucau auguacauca      540

ugcaacugca acgaaccagu aggaguaaca gacaaauucg aaaacagaaa acacauagaa      600

uucucauucc aaccaguaug caaagcagaa augucaccaa gugaaguauc agacuaa         657


<210>  4545
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__P08700

<400>  4545

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  4546
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__AAA35725

<400>  4546
augagccgcc ugcccguccu gcuccugcuc caacuccugg uccgccccgg acuccaagcu       60

cccaugaccc agacaacgcc cuugaagaca agcuggguua acugcucuaa caugaucgau      120

gaaauuauaa cacacuuaaa gcagccaccu uugccuuugc uggacuucaa caaccucaau      180

ggggaagacc aagacauucu gauggaaaau aaccuucgaa ggccaaaccu ggaggcauuc      240

aacagggcug ucaagaguuu acagaacgca ucagcaauug agagcauucu uaaaaaucuc      300

cugccauguc ugccccuggc cacggccgca cccacgcgac auccaaucca uaucaaggac      360

ggugacugga augaauuccg gaggaaacug acguucuauc ugaaaacccu ugagaaugcg      420

caggcucaac agacgacuuu gagccucgcg aucuuuuga                             459


<210>  4547
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-3__Homo_sapiens__AAA35725

<400>  4547
augagccgcc ugcccgugcu ccugcugcuc cagcugcugg uccggccggg ccuccaggcc       60

cccaugaccc agaccacgcc ccugaagacc uccuggguga acugcagcaa caugaucgac      120

gagaucauca cccaccugaa gcagcccccg cucccccugc uggacuucaa caaccucaac      180

ggggaggacc aggacauccu gauggagaac aaccugcgcc ggcccaaccu cgaggccuuc      240

aaccgcgcgg ugaagucccu gcagaacgcc agcgccaucg aguccauccu gaagaaccuc      300

cugcccugcc ugccgcucgc caccgccgcg cccacgcggc accccaucca caucaaggac      360

ggcgacugga acgaguuccg ccggaagcug accuucuacc ugaagacccu cgagaacgcc      420

caggcccagc agaccacgcu gagccuggcc aucuucuga                             459


<210>  4548
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-3__Homo_sapiens__AAA35725

<400>  4548
augucccgcc uccccguccu ccuccuccuc cagcuccucg uccgccccgg ccuccaggcc       60

cccaugaccc agaccacccc ccucaagacc uccuggguca acugcuccaa caugaucgac      120

gagaucauca cccaccucaa gcagcccccc cucccccucc ucgacuucaa caaccucaac      180

ggcgaggacc aggacauccu cauggagaac aaccuccgcc gccccaaccu cgaggccuuc      240

aaccgcgccg ucaagucccu ccagaacgcc uccgccaucg aguccauccu caagaaccuc      300

cuccccugcc ucccccucgc caccgccgcc cccacccgcc accccaucca caucaaggac      360

ggcgacugga acgaguuccg ccgcaagcuc accuucuacc ucaagacccu cgagaacgcc      420

caggcccagc agaccacccu cucccucgcc aucuucuga                             459


<210>  4549
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-3__Homo_sapiens__AAA35725

<400>  4549
augagcagac ugcccgugcu ccuucuguug caguuacugg ucaggccugg ccuacaagcc       60

ccaaugaccc agacaacucc gcucaagacg uccuggguua acugcucuaa uaugaucgac      120

gagauuauaa cccaccugaa acagcccccu cuuccacugu uggauuucaa caaucucaac      180

ggggaagacc aggauauccu gauggagaau aaccugcggc gccccaaucu cgaggcuuuu      240

aaccgagcag ugaagucauu acaaaaugcc agugcgauug aaagcauccu gaaaaaccuu      300

uugccuuguc ugccacuagc uacagccgca cccacucguc auccuauuca caucaaggac      360

ggagauugga augaguucag aaggaaacuc accuuuuacc ugaagacacu ugaaaacgcc      420

caggcucagc agaccacucu guccuuggca auauucuga                             459


<210>  4550
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-3__Homo_sapiens__AAA35725

<400>  4550
augagcagac ugcccgugcu gcugcugcug cagcugcugg ugagacccgg ccugcaggcc       60

cccaugaccc agaccacccc ccugaagacc agcuggguga acugcagcaa caugaucgac      120

gagaucauca cccaccugaa gcagcccccc cugccccugc uggacuucaa caaccugaac      180

ggcgaggacc aggacauccu gauggagaac aaccugagaa gacccaaccu ggaggccuuc      240

aacagagccg ugaagagccu gcagaacgcc agcgccaucg agagcauccu gaagaaccug      300

cugcccugcc ugccccuggc caccgccgcc cccaccagac accccaucca caucaaggac      360

ggcgacugga acgaguucag aagaaagcug accuucuacc ugaagacccu ggagaacgcc      420

caggcccagc agaccacccu gagccuggcc aucuucuga                             459


<210>  4551
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-3__Homo_sapiens__AAA35725

<400>  4551
augagcagac ugcccgugcu ccugcuucug cagcuccugg ugcggccugg ccuucaagcc       60

ccgaugaccc agacaacgcc ccugaagacc uccuggguua acugcucuaa uaugaucgac      120

gagauuauca cacaccucaa acagccuccc cugccucugc ucgauuucaa caaucugaac      180

ggggaagacc aggauauucu uauggagaau aaccugcgca gacccaaucu cgaggcuuuu      240

aaccgggccg ucaagagccu gcaaaaugcg uccgcuaucg aaucuauucu uaaaaaccug      300

cucccuuguc ugccgcuggc caccgccgcu cccacacgcc auccuaucca caucaaggac      360

ggagauugga augaguucag acggaaacuc accuuuuacc ugaagacacu ugaaaacgcc      420

caggcucagc agaccacgcu gagccucgcc auuuucuga                             459


<210>  4552
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-3__Homo_sapiens__AAA35725

<400>  4552
augucaagac uacccguacu acuacuacua caacuacuag uaagaccagg acuacaagca       60

ccaaugacac aaacaacacc acuaaaaaca uccuggguaa acugcucaaa caugauagac      120

gaaauaauca cacaccuaaa acaaccacca cuaccacuac uagacuucaa caaccuaaac      180

ggagaagacc aagacauacu cauggaaaac aaccuaagaa gaccaaaccu agaagcauuc      240

aacagagccg uaaaaucacu acaaaacgca ucagcaauag aaucaauacu aaaaaaccua      300

cuaccaugcc ucccacuagc aacagcagca ccaacaagac acccaauaca cauaaaagac      360

ggagacugga acgaauucag aagaaaacua acauucuacc uaaaaacacu agaaaacgca      420

caagcacaac aaacaacacu cucacuagca auauucuaa                             459


<210>  4553
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__Q6NZ78

<400>  4553

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Ser Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  4554
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__AAH66275

<400>  4554
augagccgcc ugcccguccu gcuccugcuc caacuccugg uccgccccgg acuccaagcu       60

cccaugaccc agacaacguc cuugaagaca agcuggguua acugcucuaa caugaucgau      120

gaaauuauaa cacacuuaaa gcagccaccu uugccuuugc uggacuucaa cagccucaau      180

ggggaagacc aagacauucu gauggaaaau aaccuucgaa ggccaaaccu ggaggcauuc      240

aacagggcug ucaagaguuu acagaacgca ucagcaauug agagcauucu uaaaaaucuc      300

cugccauguc ugccccuggc cacggccgca cccacgcgac auccaaucca uaucaaggac      360

ggugacugga augaauuccg gaggaaacug acguucuauc ugaaaacccu ugagaaugcg      420

caggcucaac agacgacuuu gagccucgcg aucuuuuga                             459


<210>  4555
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-3__Homo_sapiens__AAH66275

<400>  4555
augagccgcc ugcccgugcu ccugcugcuc cagcugcugg uccggccggg ccuccaggcc       60

cccaugaccc agaccacguc ccugaagacc agcuggguga acugcuccaa caugaucgac      120

gagaucauca cccaccugaa gcagccgccc cucccccugc uggacuucaa cagccucaac      180

ggggaggacc aggacauccu gauggagaac aaccugcgcc ggcccaaccu cgaggccuuc      240

aaccgcgcgg ugaagucccu gcagaacgcc agcgccaucg aguccauccu gaagaaccuc      300

cugcccugcc ugccccucgc caccgccgcg ccgacgcggc accccaucca caucaaggac      360

ggcgacugga acgaguuccg ccggaagcug accuucuacc ugaagacccu cgagaacgcc      420

caggcccagc agaccacgcu gagccuggcc aucuucuga                             459


<210>  4556
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-3__Homo_sapiens__AAH66275

<400>  4556
augucccgcc uccccguccu ccuccuccuc cagcuccucg uccgccccgg ccuccaggcc       60

cccaugaccc agaccaccuc ccucaagacc uccuggguca acugcuccaa caugaucgac      120

gagaucauca cccaccucaa gcagcccccc cucccccucc ucgacuucaa cucccucaac      180

ggcgaggacc aggacauccu cauggagaac aaccuccgcc gccccaaccu cgaggccuuc      240

aaccgcgccg ucaagucccu ccagaacgcc uccgccaucg aguccauccu caagaaccuc      300

cuccccugcc ucccccucgc caccgccgcc cccacccgcc accccaucca caucaaggac      360

ggcgacugga acgaguuccg ccgcaagcuc accuucuacc ucaagacccu cgagaacgcc      420

caggcccagc agaccacccu cucccucgcc aucuucuga                             459


<210>  4557
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-3__Homo_sapiens__AAH66275

<400>  4557
augagcagac ugcccgugcu ccuucuguug caguuacugg ugaggccugg ccuacaagcc       60

ccaaugaccc agacaacuuc ccucaagacg ucuuggguua acugcucaaa uaugaucgac      120

gagauuauaa cccaccugaa acagccgccc cuuccucugu uggauuucaa cagucucaau      180

ggggaagacc aggauauccu gauggagaac aaucugcggc gcccaaaccu cgaggcuuuu      240

aaucgagcag ucaagagcuu acaaaacgcc uccgcgauug aaucuauccu gaaaaaucuu      300

uugcccuguc ugccucuagc uacagccgca ccaacucguc aucccauuca caucaaggac      360

ggagauugga acgaguucag aaggaaacuc accuuuuacc ugaagacacu ugaaaaugcc      420

caggcucagc agaccacucu gucguuggca auauucuga                             459


<210>  4558
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-3__Homo_sapiens__AAH66275

<400>  4558
augagcagac ugcccgugcu gcugcugcug cagcugcugg ugagacccgg ccugcaggcc       60

cccaugaccc agaccaccag ccugaagacc agcuggguga acugcagcaa caugaucgac      120

gagaucauca cccaccugaa gcagcccccc cugccccugc uggacuucaa cagccugaac      180

ggcgaggacc aggacauccu gauggagaac aaccugagaa gacccaaccu ggaggccuuc      240

aacagagccg ugaagagccu gcagaacgcc agcgccaucg agagcauccu gaagaaccug      300

cugcccugcc ugccccuggc caccgccgcc cccaccagac accccaucca caucaaggac      360

ggcgacugga acgaguucag aagaaagcug accuucuacc ugaagacccu ggagaacgcc      420

caggcccagc agaccacccu gagccuggcc aucuucuga                             459


<210>  4559
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-3__Homo_sapiens__AAH66275

<400>  4559
augagcagac ugcccgugcu ccugcuucug cagcuccugg uccggccugg ccuucaagcc       60

ccgaugaccc agacaacguc ccugaagacc ucuuggguua acugcagcaa uaugaucgac      120

gagauuauca cacaccucaa acagcccccu cugccccugc ucgauuucaa cucccugaau      180

ggggaagacc aggauauucu uauggagaac aaucugcgca gaccuaaccu cgaggcuuuu      240

aaucgggccg ugaagucucu gcaaaacgcg agcgcuaucg aauccauucu uaaaaaucug      300

cuccccuguc ugccucuggc caccgccgcu ccgacacgcc aucccaucca caucaaggac      360

ggagauugga acgaguucag acggaaacuc accuuuuacc ugaagacacu ugaaaaugcc      420

caggcucagc agaccacgcu gucucucgcc auuuucuga                             459


<210>  4560
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-3__Homo_sapiens__AAH66275

<400>  4560
augucaagac uaccaguacu acuacuccua caauuacuag uaagaccagg acuacaagca       60

ccaaugacac aaaccacauc ccuaaaaaca ucauggguaa acugcucaaa caugaucgac      120

gaaauaauaa cacacuuaaa acaaccacca cuaccacuac uagacuucaa cucacuaaac      180

ggagaagacc aagacauacu cauggaaaac aaccuaagaa gaccaaaccu agaagcauuc      240

aacagagcag uaaaaucacu acaaaacgca ucagcaauag aauccauacu aaaaaaccua      300

cucccaugcc uaccacuagc aacagcagca ccaacaagac acccaauaca cauaaaagac      360

ggagacugga acgaauucag acgaaaacua acauucuacc uaaaaacacu agaaaacgca      420

caagcacaac aaacaacacu aucacuagca auauucuaa                             459


<210>  4561
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__Q6NZ79

<400>  4561

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr Arg Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  4562
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-3__Homo_sapiens__AAH66274

<400>  4562
augagccgcc ugcccguccu gcuccugcuc caacuccugg uccgccccgg acuccaagcu       60

cccaugaccc agacaacguc cuugaagaca agcuggguua acugcucuaa caugaucgau      120

gaaauuauaa cacgcuuaaa gcagccaccu uugccuuugc uggacuucaa caaccucaau      180

ggggaagacc aagacauucu gauggaaaau aaccuucgaa ggccaaaccu ggaggcauuc      240

aacagggcug ucaagaguuu acagaacgca ucagcaauug agagcauucu uaaaaaucuc      300

cugccauguc ugccccuggc cacggccgca cccacgcgac auccaaucca uaucaaggac      360

ggugacugga augaauuccg gaggaaacug acguucuauc ugaaaacccu ugagaaugcg      420

caggcucaac agacgacuuu gagccucgcg aucuuuuga                             459


<210>  4563
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-3__Homo_sapiens__AAH66274

<400>  4563
augagccgcc ugcccgugcu ccugcugcuc cagcugcugg ugcggccggg ccuccaggcc       60

cccaugaccc agaccacguc ccugaagacc agcuggguga acugcuccaa caugaucgac      120

gagaucauca cccgccugaa gcagccgccc cucccccugc uggacuucaa caaccucaac      180

ggggaggacc aggacauccu gauggagaac aaccugcggc gccccaaccu cgaggccuuc      240

aaccgggcgg ucaagagccu gcagaacgcc uccgccaucg agagcauccu gaagaaccuc      300

cugcccugcc ugccccucgc caccgccgcg ccgacgcgcc accccaucca caucaaggac      360

ggcgacugga acgaguuccg gcgcaagcug accuucuacc ugaagacccu cgagaacgcc      420

caggcccagc agaccacgcu gucccuggcc aucuucuga                             459


<210>  4564
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-3__Homo_sapiens__AAH66274

<400>  4564
augucccgcc uccccguccu ccuccuccuc cagcuccucg uccgccccgg ccuccaggcc       60

cccaugaccc agaccaccuc ccucaagacc uccuggguca acugcuccaa caugaucgac      120

gagaucauca cccgccucaa gcagcccccc cucccccucc ucgacuucaa caaccucaac      180

ggcgaggacc aggacauccu cauggagaac aaccuccgcc gccccaaccu cgaggccuuc      240

aaccgcgccg ucaagucccu ccagaacgcc uccgccaucg aguccauccu caagaaccuc      300

cuccccugcc ucccccucgc caccgccgcc cccacccgcc accccaucca caucaaggac      360

ggcgacugga acgaguuccg ccgcaagcuc accuucuacc ucaagacccu cgagaacgcc      420

caggcccagc agaccacccu cucccucgcc aucuucuga                             459


<210>  4565
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-3__Homo_sapiens__AAH66274

<400>  4565
augagcagac ugcccgugcu ccuucuguug caguuacugg ucaggccugg ccuacaagcc       60

ccaaugaccc agacaacuuc ccucaagacg ucuuggguua acugcucaaa uaugaucgac      120

gagauuauaa cccggcugaa acagccgccc cuuccucugu uggauuucaa caaucucaac      180

ggggaagacc aggauauccu gauggagaau aaccugcgcc gaccaaaucu cgaggcuuuu      240

aaccgugcag ugaagaguuu acaaaaugcc agcgcgauug aauccauccu gaaaaaccuu      300

uugcccuguc ugccucuagc uacagccgca ccaacuagac accccauuca uaucaaggac      360

ggagauugga augaguucag gcggaaacuc accuuuuacc ugaagacacu ugaaaacgcc      420

caggcucagc agaccacucu gucuuuggca auauucuga                             459


<210>  4566
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-3__Homo_sapiens__AAH66274

<400>  4566
augagcagac ugcccgugcu gcugcugcug cagcugcugg ugagacccgg ccugcaggcc       60

cccaugaccc agaccaccag ccugaagacc agcuggguga acugcagcaa caugaucgac      120

gagaucauca ccagacugaa gcagcccccc cugccccugc uggacuucaa caaccugaac      180

ggcgaggacc aggacauccu gauggagaac aaccugagaa gacccaaccu ggaggccuuc      240

aacagagccg ugaagagccu gcagaacgcc agcgccaucg agagcauccu gaagaaccug      300

cugcccugcc ugccccuggc caccgccgcc cccaccagac accccaucca caucaaggac      360

ggcgacugga acgaguucag aagaaagcug accuucuacc ugaagacccu ggagaacgcc      420

caggcccagc agaccacccu gagccuggcc aucuucuga                             459


<210>  4567
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-3__Homo_sapiens__AAH66274

<400>  4567
augagcagac ugcccgugcu ccugcuucug cagcuccugg uccggccugg ccuucaagcc       60

ccgaugaccc agacaacguc ccugaagacc ucuuggguua acugcagcaa uaugaucgac      120

gagauuauca cacgccucaa acagcccccu cugccccugc ucgauuucaa caaucugaac      180

ggggaagacc aggauauucu uauggagaau aaccugagac ggccuaaucu cgaggcuuuu      240

aaccgcgccg ugaagucccu gcaaaaugcg ucugcuaucg aaagcauucu uaaaaaccug      300

cuccccuguc ugccucuggc caccgccgcu ccgacaagac accccaucca uaucaaggac      360

ggagauugga augaguuccg gcgcaaacuc accuuuuacc ugaagacacu ugaaaacgcc      420

caggcucagc agaccacgcu gucccucgcc auuuucuga                             459


<210>  4568
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-3__Homo_sapiens__AAH66274

<400>  4568
augucaagac uaccaguacu acuacuacua caacuacuag uaagaccagg acuacaagca       60

ccaaugaccc aaacaacauc acuaaaaaca uccuggguaa acugcucaaa caugauagac      120

gaaauaauaa caagacuaaa acaaccacca cuaccacuac uagacuucaa caaccuaaac      180

ggagaagacc aagacauacu aauggaaaac aaccuaagaa gaccaaaccu agaagcauuc      240

aaccgagcag uaaaaucacu acaaaacgca ucagcaauag aauccauacu aaaaaaccua      300

cuaccaugcc uaccacuagc aacagcagca ccaacaagac acccaauaca cauaaaagac      360

ggagacugga acgaauucag aagaaaacua acauucuacc uaaaaacacu agaaaacgca      420

caagcacaac aaacaacacu cucacuagca auauucuaa                             459


<210>  4569
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-4__Homo_sapiens__P05112-2

<400>  4569

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr 
        35                  40                  45              


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
    50                  55                  60                  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
65                  70                  75                  80  


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
                85                  90                  95      


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
            100                 105                 110         


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
        115                 120                 125             


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
    130                 135         


<210>  4570
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-4__Homo_sapiens__CCDS4159.1

<400>  4570
augggucuca ccucccaacu gcuucccccu cuguucuucc ugcuagcaug ugccggcaac       60

uuuguccacg gacacaagug cgauaucacc uuacaggaga ucaucaaaac uuugaacagc      120

cucacagagc agaagaacac aacugagaag gaaaccuucu gcagggcugc gacugugcuc      180

cggcaguucu acagccacca ugagaaggac acucgcugcc ugggugcgac ugcacagcag      240

uuccacaggc acaagcagcu gauccgauuc cugaaacggc ucgacaggaa ccucuggggc      300

cuggcgggcu ugaauuccug uccugugaag gaagccaacc agaguacguu ggaaaacuuc      360

uuggaaaggc uaaagacgau caugagagag aaauauucaa aguguucgag cuga            414


<210>  4571
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4571
augggccuga ccagccagcu ccugcccccg cuguucuucc uccuggccug cgccgggaac       60

uucgugcacg gccacaagug cgacaucacc cugcaggaga ucaucaagac gcucaacucc      120

cugaccgagc agaagaacac caccgagaag gagacguucu gccgcgcggc caccguccug      180

cggcaguucu acagccacca cgagaaggac acccgcugcc ucggggccac cgcccagcag      240

uuccaccggc acaagcagcu gauccgcuuc cugaagcggc ucgaccgcaa ccuguggggc      300

cuggccgggc ucaacuccug ccccgugaag gaggcgaacc agagcacgcu ggagaacuuc      360

cuggagcggc ucaagaccau caugcgcgag aaguacucca agugcagcuc cuga            414


<210>  4572
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4572
augggccuca ccucccagcu ccuccccccc cucuucuucc uccucgccug cgccggcaac       60

uucguccacg gccacaagug cgacaucacc cuccaggaga ucaucaagac ccucaacucc      120

cucaccgagc agaagaacac caccgagaag gagaccuucu gccgcgccgc caccguccuc      180

cgccaguucu acucccacca cgagaaggac acccgcugcc ucggcgccac cgcccagcag      240

uuccaccgcc acaagcagcu cauccgcuuc cucaagcgcc ucgaccgcaa ccucuggggc      300

cucgccggcc ucaacuccug ccccgucaag gaggccaacc aguccacccu cgagaacuuc      360

cucgagcgcc ucaagaccau caugcgcgag aaguacucca agugcuccuc cuga            414


<210>  4573
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4573
augggccuga ccagccagcu ccuucccccu cuguucuuuu uguuagccug cgcugggaac       60

uucgugcacg gacauaagug ugacaucaca cugcaagaga uuauaaaaac ucuaaauucc      120

cucacggaac agaagaacac cacagagaaa gaaacuuuuu gcagagcagc caccguccug      180

aggcaguucu acucucacca ugagaaggau acacgguguc uuggugcgac cgcucagcaa      240

uuucaccgcc auaaacagcu gauccgauuc uugaagcguc ucgacagaaa ucuguggggc      300

cuggccgggc ucaacucaug cccaguuaag gaagcaaauc agaguacuuu agagaacuuu      360

cuggagaggc uuaaaacaau uaugcgggaa aaguauagca aauguuccuc uuga            414


<210>  4574
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4574
augggccuga ccagccagcu gcugcccccc cuguucuucc ugcuggccug cgccggcaac       60

uucgugcacg gccacaagug cgacaucacc cugcaggaga ucaucaagac ccugaacagc      120

cugaccgagc agaagaacac caccgagaag gagaccuucu gcagagccgc caccgugcug      180

agacaguucu acagccacca cgagaaggac accagaugcc ugggcgccac cgcccagcag      240

uuccacagac acaagcagcu gaucagauuc cugaagagac uggacagaaa ccuguggggc      300

cuggccggcc ugaacagcug ccccgugaag gaggccaacc agagcacccu ggagaacuuc      360

cuggagagac ugaagaccau caugagagag aaguacagca agugcagcag cuga            414


<210>  4575
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4575
augggccuga ccagccagcu ccugcccccu cuuuucuuuc ugcucgccug cgcugggaac       60

uucgugcacg gacauaagug ugacaucaca cugcaagaga uuaucaaaac gcuuaauucc      120

cugaccgaac agaagaacac aaccgagaaa gaaacauuuu gcagagccgc gaccguccuc      180

cggcaguucu acucucacca ugagaaggau acacgcuguc ugggcgcuac cgcccagcaa      240

uuucacagac auaaacagcu gauucgguuc cucaagcgcc uggacagaaa ucuuuggggg      300

cuggccggac ucaacagcug cccgguuaag gaagcuaauc aguccacgcu ggagaacuuu      360

cuugagcggc ugaaaaccau caugcgcgaa aaguauucua aauguagcuc cuga            414


<210>  4576
<211>  414
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-4__Homo_sapiens__CCDS4159.1

<400>  4576
augggacuaa caagccaacu acuaccacca cuauucuucc uacucgcaug cgcaggaaac       60

uucguacacg gacacaaaug cgacauaaca cuacaagaaa uaauaaaaac acuaaacuca      120

cuaacagaac aaaaaaacac aacagaaaaa gaaacauucu gcagagcagc aacaguauua      180

agacaauucu acagccacca cgaaaaagac acaagaugcc uaggagcaac agcacaacaa      240

uuccacagac acaaacaacu aauacgauuc cucaaaagac uagacagaaa ccuaugggga      300

cuagcaggac uaaacucaug cccaguaaaa gaagcaaacc aaagcacacu agaaaacuuu      360

cuagaaagac uaaaaacaau aaugagagaa aaauacagca aaugcucaag cuaa            414


<210>  4577
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-4__Homo_sapiens__P05112

<400>  4577

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  4578
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-4__Homo_sapiens__CCDS4158.1

<400>  4578
augggucuca ccucccaacu gcuucccccu cuguucuucc ugcuagcaug ugccggcaac       60

uuuguccacg gacacaagug cgauaucacc uuacaggaga ucaucaaaac uuugaacagc      120

cucacagagc agaagacucu gugcaccgag uugaccguaa cagacaucuu ugcugccucc      180

aagaacacaa cugagaagga aaccuucugc agggcugcga cugugcuccg gcaguucuac      240

agccaccaug agaaggacac ucgcugccug ggugcgacug cacagcaguu ccacaggcac      300

aagcagcuga uccgauuccu gaaacggcuc gacaggaacc ucuggggccu ggcgggcuug      360

aauuccuguc cugugaagga agccaaccag aguacguugg aaaacuucuu ggaaaggcua      420

aagacgauca ugagagagaa auauucaaag uguucgagcu ga                         462


<210>  4579
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4579
augggccuga ccagccagcu ccugcccccg cuguucuucc uccuggccug cgccgggaac       60

uucgugcacg gccacaagug cgacaucacc cugcaggaga ucaucaagac gcucaacucc      120

cugaccgagc agaagacccu gugcaccgag cucacgguca ccgacaucuu cgcggccagc      180

aagaacacca ccgagaagga gacguucugc cgcgccgcca ccgugcugcg gcaguucuac      240

ucccaccacg agaaggacac ccgcugccug ggggccaccg cgcagcaguu ccaccggcac      300

aagcagcuca uccgcuuccu gaagcggcug gaccgcaacc ucuggggccu ggccgggcug      360

aacagcugcc ccgugaagga ggccaaccag uccacgcucg agaacuuccu ggagcggcug      420

aagaccauca ugcgcgagaa guacagcaag ugcuccagcu ga                         462


<210>  4580
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4580
augggccuca ccucccagcu ccuccccccc cucuucuucc uccucgccug cgccggcaac       60

uucguccacg gccacaagug cgacaucacc cuccaggaga ucaucaagac ccucaacucc      120

cucaccgagc agaagacccu cugcaccgag cucaccguca ccgacaucuu cgccgccucc      180

aagaacacca ccgagaagga gaccuucugc cgcgccgcca ccguccuccg ccaguucuac      240

ucccaccacg agaaggacac ccgcugccuc ggcgccaccg cccagcaguu ccaccgccac      300

aagcagcuca uccgcuuccu caagcgccuc gaccgcaacc ucuggggccu cgccggccuc      360

aacuccugcc ccgucaagga ggccaaccag uccacccucg agaacuuccu cgagcgccuc      420

aagaccauca ugcgcgagaa guacuccaag ugcuccuccu ga                         462


<210>  4581
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4581
augggccuga ccagccagcu ccuucccccu cuguucuuuu uguuagccug cgcugggaac       60

uucgugcacg gacauaagug cgacaucaca cugcaagaga uuauaaaaac ucuaaauucc      120

cucacggaac agaagacccu gugcacagag cuuacuguca ccgauaucuu ugcagccucu      180

aaaaacacaa ccgaaaagga gacuuucugu agagcggcua caguucugag gcaguuuuac      240

ucacaccaug aaaaagacac ccggugcuug ggugccacgg cacagcaauu ccaccgccau      300

aagcagcuca uucgauuucu gaagcgucug gauagaaauc ucuggggcuu agccgggcug      360

aacaguuguc cagugaaaga ggcuaaucag agcacucuug agaacuucuu ggaaaggcug      420

aagaccauca ugcgggagaa auauuccaag uguucuucgu ga                         462


<210>  4582
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4582
augggccuga ccagccagcu gcugcccccc cuguucuucc ugcuggccug cgccggcaac       60

uucgugcacg gccacaagug cgacaucacc cugcaggaga ucaucaagac ccugaacagc      120

cugaccgagc agaagacccu gugcaccgag cugaccguga ccgacaucuu cgccgccagc      180

aagaacacca ccgagaagga gaccuucugc agagccgcca ccgugcugag acaguucuac      240

agccaccacg agaaggacac cagaugccug ggcgccaccg cccagcaguu ccacagacac      300

aagcagcuga ucagauuccu gaagagacug gacagaaacc uguggggccu ggccggccug      360

aacagcugcc ccgugaagga ggccaaccag agcacccugg agaacuuccu ggagagacug      420

aagaccauca ugagagagaa guacagcaag ugcagcagcu ga                         462


<210>  4583
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4583
augggccuga ccagccagcu ccugcccccu cuuuucuuuc ugcucgccug cgcugggaac       60

uucgugcacg gacauaagug ugacaucaca cugcaagaga uuaucaaaac gcuuaauucc      120

cugaccgaac agaagacacu cugcaccgag cugacaguca ccgauauuuu ugccgcgucu      180

aaaaacacaa ccgaaaagga gacguucugu agagcugcca ccguucugcg gcaguuuuac      240

agccaccaug aaaaagacac acgcugccuc ggcgccaccg cucagcaauu ccacagacau      300

aagcagcuga uccgguuucu uaagcgccug gauagaaauc ucugggggcu ggccggacuu      360

aacuccuguc cggugaaaga ggcuaaucag ucuacacugg agaacuuccu cgaacggcug      420

aagaccauua ugcgcgagaa auauagcaag ugcuccucuu ga                         462


<210>  4584
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-4__Homo_sapiens__CCDS4158.1

<400>  4584
augggacuaa caucacaacu acuaccacca cuauucuucc uacuagcaug cgcaggaaac       60

uucguccacg gacacaaaug cgacauaaca cuacaagaaa uaauaaaaac acuaaacuca      120

cuaacagaac aaaaaacacu augcacagaa cuaacaguaa cagacauauu cgcagcauca      180

aaaaacacaa cagaaaaaga aacauucugc agagcagcaa caguauuacg acaauucuac      240

ucacaccacg aaaaagacac aagaugccua ggagcaacag cacaacaauu ccaccgacac      300

aaacaacuaa uaagauuccu aaaaagacua gacagaaacc uauggggacu agcaggauua      360

aacucaugcc caguaaaaga agcaaaccaa agcacacuag aaaacuuccu agaaagacua      420

aaaacaauaa ugagagaaaa auacucaaaa ugcucaucau aa                         462


<210>  4585
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-5__Homo_sapiens__P05113

<400>  4585

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  4586
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-5__Homo_sapiens__AAA74469

<400>  4586
augaggaugc uucugcauuu gaguuugcua gcucuuggag cugccuacgu guaugccauc       60

cccacagaaa uucccacaag ugcauuggug aaagagaccu uggcacugcu uucuacucau      120

cgaacucugc ugauagccaa ugagacucug aggauuccug uuccuguaca uaaaaaucac      180

caacugugca cugaagaaau cuuucaggga auaggcacac uggagaguca aacugugcaa      240

ggggguacug uggaaagacu auucaaaaac uuguccuuaa uaaagaaaua cauugacggc      300

caaaaaaaaa aguguggaga agaaagacgg agaguaaacc aauuccuaga cuaccugcaa      360

gaguuucuug guguaaugaa caccgagugg auaauagaaa guuga                      405


<210>  4587
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-5__Homo_sapiens__AAA74469

<400>  4587
augcgcaugc ugcuccaccu gagccugcuc gcccugggcg ccgcguacgu guacgccauc       60

cccaccgaga ucccgaccuc cgcccugguc aaggagacgc ucgcccugcu gagcacccac      120

cggacccucc ugaucgccaa cgagacccug cgcauccccg ugcccgugca caagaaccac      180

cagcucugca cggaggagau cuuccagggg aucggcaccc uggaguccca gaccguccag      240

ggcgggaccg uggagcggcu guucaagaac cucagccuga ucaagaagua caucgacggg      300

cagaagaaga agugcggcga ggagcgccgg cgcgugaacc aguuccugga cuaccuccag      360

gaguuccugg gcgucaugaa cacggagugg aucaucgagu ccuga                      405


<210>  4588
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-5__Homo_sapiens__AAA74469

<400>  4588
augcgcaugc uccuccaccu cucccuccuc gcccucggcg ccgccuacgu cuacgccauc       60

cccaccgaga uccccaccuc cgcccucguc aaggagaccc ucgcccuccu cuccacccac      120

cgcacccucc ucaucgccaa cgagacccuc cgcauccccg uccccgucca caagaaccac      180

cagcucugca ccgaggagau cuuccagggc aucggcaccc ucgaguccca gaccguccag      240

ggcggcaccg ucgagcgccu cuucaagaac cucucccuca ucaagaagua caucgacggc      300

cagaagaaga agugcggcga ggagcgccgc cgcgucaacc aguuccucga cuaccuccag      360

gaguuccucg gcgucaugaa caccgagugg aucaucgagu ccuga                      405


<210>  4589
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-5__Homo_sapiens__AAA74469

<400>  4589
augagaaugc ugcuccaccu uagccuguug gccuuaggcg cugcauacgu guaugccauc       60

cccaccgaga uuccuacauc cgcgcugguc aaggaaacuc uagcucuccu gucuacgcau      120

aggacccuuc ugauagccaa cgagacauug cggaucccag uuccggugca caaaaaucau      180

cagcucugca cugaagagau uuuccaaggg aucggaaccc uggaaucaca gacaguacag      240

gguggcaccg uggagcgccu guuuaagaac cucaguuuaa uuaaaaagua caucgacggg      300

cagaaaaaga aguguggaga ggaacgacgu agagucaauc aauuccugga uuaucuucag      360

gaguuuuugg gcgugaugaa cacugaaugg auaaucgaga gcuga                      405


<210>  4590
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-5__Homo_sapiens__AAA74469

<400>  4590
augagaaugc ugcugcaccu gagccugcug gcccugggcg ccgccuacgu guacgccauc       60

cccaccgaga uccccaccag cgcccuggug aaggagaccc uggcccugcu gagcacccac      120

agaacccugc ugaucgccaa cgagacccug agaauccccg ugcccgugca caagaaccac      180

cagcugugca ccgaggagau cuuccagggc aucggcaccc uggagagcca gaccgugcag      240

ggcggcaccg uggagagacu guucaagaac cugagccuga ucaagaagua caucgacggc      300

cagaagaaga agugcggcga ggagagaaga agagugaacc aguuccugga cuaccugcag      360

gaguuccugg gcgugaugaa caccgagugg aucaucgaga gcuga                      405


<210>  4591
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-5__Homo_sapiens__AAA74469

<400>  4591
augagaaugc ugcuccaccu gagccuucug gcccucggcg cugccuacgu guaugcgauc       60

cccaccgaga uuccuacauc cgcucugguc aaggaaacgc uugcccugcu cucuacccau      120

cggacacugc ugaucgccaa cgagacccuc cgcauuccgg uucccgugca caaaaaucau      180

cagcugugca cagaagagau cuuccaaggg auuggaaccc uugaaagcca gacagugcag      240

ggcgggaccg ucgagagacu guuuaagaac cucucccuga ucaaaaagua caucgacgga      300

cagaaaaaga aguguggcga ggaacggcgc agagugaauc aauuccuuga uuaucugcag      360

gaguuucucg ggguuaugaa cacggaaugg auuaucgagu cuuga                      405


<210>  4592
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-5__Homo_sapiens__AAA74469

<400>  4592
augagaaugc uacuacaccu aucacuacua gcacuaggag cagcauacgu auacgcaaua       60

ccaacagaaa uaccaacauc agcacuaguc aaagaaacac uagcacuacu aucaacacac      120

agaacacuau uaauagcaaa cgaaacccua agaauaccag uaccaguaca caaaaaccac      180

caacuaugca cagaagaaau auuccaagga auaggaacac uagaaucaca aacaguacaa      240

ggaggaacag uagaaagacu auucaaaaac cuaucauuaa uaaaaaaaua cauagacgga      300

caaaaaaaaa aaugcggaga agaaagacga agaguaaacc aauuccuaga cuacuuacaa      360

gaauuccuag gaguaaugaa cacagaaugg auaauagaau cauaa                      405


<210>  4593
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-6__Homo_sapiens__P05231

<400>  4593

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  4594
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-6__Homo_sapiens__AAA52728

<400>  4594
augaacuccu ucuccacaag cgccuucggu ccaguugccu ucucccuggg gcugcuccug       60

guguugccug cugccuuccc ugccccagua cccccaggag aagauuccaa agauguagcc      120

gccccacaca gacagccacu caccucuuca gaacgaauug acaaacaaau ucgguacauc      180

cucgacggca ucucagcccu gagaaaggag acauguaaca agaguaacau gugugaaagc      240

agcaaagagg cacuggcaga aaacaaccug aaccuuccaa agauggcuga aaaagaugga      300

ugcuuccaau cuggauucaa ugaggagacu ugccugguga aaaucaucac uggucuuuug      360

gaguuugagg uauaccuaga guaccuccag aacagauuug agaguaguga ggaacaagcc      420

agagcugucc agaugaguac aaaaguccug auccaguucc ugcagaaaaa ggcaaagaau      480

cuagaugcaa uaaccacccc ugacccaacc acaaaugcca gccugcugac gaagcugcag      540

gcacagaacc aguggcugca ggacaugaca acucaucuca uucugcgcag cuuuaaggag      600

uuccugcagu ccagccugag ggcucuucgg caaauguag                             639


<210>  4595
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-6__Homo_sapiens__AAA52728

<400>  4595
augaacagcu ucuccaccag cgccuucggc cccguggccu ucucccuggg gcuccugcug       60

guccucccgg cggccuuccc cgcccccgug cccccgggcg aggacagcaa ggacguggcc      120

gcgccccacc gccagccccu gaccuccagc gagcggaucg acaagcagau ccgcuacauc      180

cuggacggga ucuccgcccu ccggaaggag acgugcaaca agagcaacau gugcgagucc      240

agcaaggagg cccuggccga gaacaaccug aaccucccca agauggccga gaaggacggc      300

ugcuuccagu ccggguucaa cgaggagacc ugccugguca agaucaucac cggccugcuc      360

gaguucgagg uguaccugga guaccugcag aaccgcuucg agagcuccga ggagcaggcg      420

cgggccgugc agaugagcac caagguccuc auccaguucc ugcagaagaa ggccaagaac      480

cuggacgcca ucacgacccc ggaccccacc accaacgccu cccuccugac gaagcugcag      540

gcgcagaacc aguggcucca ggacaugacc acccaccuga uccugcgcag cuucaaggag      600

uuccuccagu ccagccugcg ggcccugcgc cagauguga                             639


<210>  4596
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-6__Homo_sapiens__AAA52728

<400>  4596
augaacuccu ucuccaccuc cgccuucggc cccgucgccu ucucccucgg ccuccuccuc       60

guccuccccg ccgccuuccc cgcccccguc ccccccggcg aggacuccaa ggacgucgcc      120

gccccccacc gccagccccu caccuccucc gagcgcaucg acaagcagau ccgcuacauc      180

cucgacggca ucuccgcccu ccgcaaggag accugcaaca aguccaacau gugcgagucc      240

uccaaggagg cccucgccga gaacaaccuc aaccucccca agauggccga gaaggacggc      300

ugcuuccagu ccggcuucaa cgaggagacc ugccucguca agaucaucac cggccuccuc      360

gaguucgagg ucuaccucga guaccuccag aaccgcuucg aguccuccga ggagcaggcc      420

cgcgccgucc agauguccac caagguccuc auccaguucc uccagaagaa ggccaagaac      480

cucgacgcca ucaccacccc cgaccccacc accaacgccu cccuccucac caagcuccag      540

gcccagaacc aguggcucca ggacaugacc acccaccuca uccuccgcuc cuucaaggag      600

uuccuccagu ccucccuccg cgcccuccgc cagauguga                             639


<210>  4597
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-6__Homo_sapiens__AAA52728

<400>  4597
augaacagcu ucuccaccuc ugccuuuggc cccguggcuu ucucacuggg gcuccuucug       60

gucuugccug cagccuuucc agcgccgguu cccccuggag aggacaguaa ggauguggcu      120

gccccacaca gacagcccuu aacaagcucc gaaaggaucg acaaacaaau ucgguacaua      180

cuggauggua ucucugcacu acgcaaggag acuugcaaua aaucgaacau gugugaauca      240

agcaaggagg cccucgcuga aaauaaccug aaucuuccua aaauggcaga gaaggacggc      300

ugcuuccaga guggguuuaa cgaggaaacg ugucugguaa agauuaucac cggauugcuc      360

gaguucgaag uguaucugga guaccugcag aaucgauuug aguccucuga agaacaggcc      420

cgugcugucc aaaugagcac aaaagugcuc auucaguucu uacagaagaa agccaagaac      480

cuggaugcga ucacuacccc agaccccaca accaaugcau cccuuuugac uaaacugcag      540

gcccaaaacc aguggcuaca ggauaugaca acccaucuca uacugagauc auuuaaggag      600

uuccuucaga guagccugag ggcuuugcgg caaauguga                             639


<210>  4598
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-6__Homo_sapiens__AAA52728

<400>  4598
augaacagcu ucagcaccag cgccuucggc cccguggccu ucagccuggg ccugcugcug       60

gugcugcccg ccgccuuccc cgcccccgug ccccccggcg aggacagcaa ggacguggcc      120

gccccccaca gacagccccu gaccagcagc gagagaaucg acaagcagau cagauacauc      180

cuggacggca ucagcgcccu gagaaaggag accugcaaca agagcaacau gugcgagagc      240

agcaaggagg cccuggccga gaacaaccug aaccugccca agauggccga gaaggacggc      300

ugcuuccaga gcggcuucaa cgaggagacc ugccugguga agaucaucac cggccugcug      360

gaguucgagg uguaccugga guaccugcag aacagauucg agagcagcga ggagcaggcc      420

agagccgugc agaugagcac caaggugcug auccaguucc ugcagaagaa ggccaagaac      480

cuggacgcca ucaccacccc cgaccccacc accaacgcca gccugcugac caagcugcag      540

gcccagaacc aguggcugca ggacaugacc acccaccuga uccugagaag cuucaaggag      600

uuccugcaga gcagccugag agcccugaga cagauguga                             639


<210>  4599
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-6__Homo_sapiens__AAA52728

<400>  4599
augaacagcu ucuccaccuc ugccuuuggc cccguggcuu ucagccuggg gcuccugcuu       60

guccugccug ccgcguuucc ggcucccguu ccucccggag aggacuccaa ggauguggcc      120

gccccucaca gacagccccu cacaucuagc gaacggaucg acaaacaaau ucgcuacauc      180

cuggauggca uuuccgcucu uagaaaggag acgugcaaua aaucuaacau gugugaaagc      240

uccaaggagg cccuggcuga aaauaaccuc aaucugccua aaauggccga gaaggacggg      300

ugcuuccaga gcggauuuaa cgaggaaacc ugucugguga agaucauuac aggccuccug      360

gaguucgaag ucuaucuuga guaccugcag aaucgguuug agucuuccga agaacaggcg      420

cgcgccgugc aaaugagcac caaaguucuc auccaguucc ugcagaagaa agcuaagaac      480

cuugaugcca ucacaacccc ggaccccaca accaaugcuu cucugcucac gaaacugcag      540

gcccaaaacc aguggcugca ggauaugacc acacaucuca uucugagauc cuuuaaggag      600

uuccuucaga gcucucugcg ggcgcuccgc caaauguga                             639


<210>  4600
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-6__Homo_sapiens__AAA52728

<400>  4600
augaacuccu ucucaacauc agcauucgga ccaguagcau ucucccucgg acuauuacua       60

guauuacccg cagcauuccc agcaccagua cccccaggag aagauucaaa agauguagca      120

gcaccacauc gacaaccacu aacaucaucc gaaagaauag acaaacaaau aagauacauc      180

cuagauggaa ucuccgcucu aagaaaagaa accugcaaua aauccaacau gugcgaauca      240

ucaaaagaag cauuagcaga aaacaaccua aaucuaccaa aaauggcaga aaaagacgga      300

ugcuuccaau caggauucaa cgaagaaaca ugccuaguaa aaauaauaac aggauuauua      360

gaauucgaag uauaccuaga auaccuacaa aacagauucg aaucuucaga agaacaagca      420

agagcaguac aaauguccac caaaguacua auacaauucu uacaaaaaaa agcaaaaaac      480

uuagacgcaa uaacaacccc agaccccaca acaaacgcau cacuacucac aaaauuacaa      540

gcccaaaacc aauggcuaca agacaugaca acacacuuaa uacuaagauc auucaaagaa      600

uuccuacaau ccucacuaag agcacuaaga caaauguaa                             639


<210>  4601
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-7__Homo_sapiens__A8K673

<400>  4601

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Ser Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  4602
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-7__Homo_sapiens__BAF84227

<400>  4602
auguuccaug uuucuuuuag guauaucuuu ggacuuccuc cccugauccu uguucuguug       60

ccaguagcau caucugauug ugauauugaa gguaaagaua gcaaacaaua ugagaguguu      120

cuaaugguca gcaucgauca auuauuggac agcaugaaag aaauugguag caauugccug      180

aauaaugaau uuaacuuuuu uaaaagacau aucugugaug cuaauaagga agguauguuu      240

uuauuccgug cugcucgcaa guugaggcaa uuucuuaaaa ugaauagcac uggugauuuu      300

gaucuccacu uauuaaaagu uucagaaggc acaacaauac uguugaacug cacuggccag      360

guuaaaggaa gaaaaccagc ugcccugggu gaagcccaac caacaaagag uuuggaagaa      420

aauaaaucuu uaaaggaaca gaaaaaacug aaugacuugu guuuccuaaa gagacuauua      480

caagagauaa aaacuuguug gaauaaaauu uugaugggca cuaaagaaca cuga            534


<210>  4603
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-7__Homo_sapiens__BAF84227

<400>  4603
auguuccacg ugagcuuccg cuacaucuuc ggccugcccc cgcucauccu gguccugcuc       60

cccguggccu ccagcgacug cgacaucgag gggaaggacu ccaagcagua cgagagcgug      120

cugauggucu ccaucgacca gcugcucgac agcaugaagg agaucggcuc caacugccug      180

aacaacgagu ucaacuucuu caagcggcac aucugcgacg ccaacaagga ggggauguuc      240

cuguuccgcg cggcccggaa gcuccgccag uuccugaaga ugaacagcac cggcgacuuc      300

gaccugcacc uccugaaggu guccgagggg accacgaucc ugcucaacug caccggccag      360

gugaagggcc ggaagcccgc cgcccugggg gaggcccagc ccaccaagag ccuggaggag      420

aacaaguccc ucaaggagca gaagaagcug aacgaccugu gcuuccucaa gcgccugcug      480

caggagauca agaccugcug gaacaagauc cucaugggca cgaaggagca cuga            534


<210>  4604
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-7__Homo_sapiens__BAF84227

<400>  4604
auguuccacg ucuccuuccg cuacaucuuc ggccuccccc cccucauccu cguccuccuc       60

cccgucgccu ccuccgacug cgacaucgag ggcaaggacu ccaagcagua cgaguccguc      120

cucauggucu ccaucgacca gcuccucgac uccaugaagg agaucggcuc caacugccuc      180

aacaacgagu ucaacuucuu caagcgccac aucugcgacg ccaacaagga gggcauguuc      240

cucuuccgcg ccgcccgcaa gcuccgccag uuccucaaga ugaacuccac cggcgacuuc      300

gaccuccacc uccucaaggu cuccgagggc accaccaucc uccucaacug caccggccag      360

gucaagggcc gcaagcccgc cgcccucggc gaggcccagc ccaccaaguc ccucgaggag      420

aacaaguccc ucaaggagca gaagaagcuc aacgaccucu gcuuccucaa gcgccuccuc      480

caggagauca agaccugcug gaacaagauc cucaugggca ccaaggagca cuga            534


<210>  4605
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-7__Homo_sapiens__BAF84227

<400>  4605
auguuccacg ugagcuuuag auacaucuuc ggccugcccc cucucauucu uguccuguug       60

ccaguugccu ccucugacug cgauauagag gggaaggacu caaaacagua ugaaagugug      120

uuaaugguaa gcaucgauca acugcuagac uccaugaagg agauuggauc uaacugucuc      180

aauaacgaau uuaauuucuu uaaaaggcau aucugcgaug cuaacaagga ggguauguuc      240

cuguuucggg cagcccgcaa acuucgacag uuccugaaga ugaacucgac cggcgacuuu      300

gauuugcacc uccugaaggu gucagaaggg acaacuauuc ugcucaauug uacgggacag      360

gucaaaggcc guaagccggc ggcuuuaggu gaggcccagc ccaccaaaag ccuggaggaa      420

aauaagaguc uuaaagagca aaagaaguug aacgaccugu gcuuccuaaa aagacuccug      480

caggaaauca agacauguug gaauaaaaua cuuaugggga cuaaggagca uuga            534


<210>  4606
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-7__Homo_sapiens__BAF84227

<400>  4606
auguuccacg ugagcuucag auacaucuuc ggccugcccc cccugauccu ggugcugcug       60

cccguggcca gcagcgacug cgacaucgag ggcaaggaca gcaagcagua cgagagcgug      120

cugaugguga gcaucgacca gcugcuggac agcaugaagg agaucggcag caacugccug      180

aacaacgagu ucaacuucuu caagagacac aucugcgacg ccaacaagga gggcauguuc      240

cuguucagag ccgccagaaa gcugagacag uuccugaaga ugaacagcac cggcgacuuc      300

gaccugcacc ugcugaaggu gagcgagggc accaccaucc ugcugaacug caccggccag      360

gugaagggca gaaagcccgc cgcccugggc gaggcccagc ccaccaagag ccuggaggag      420

aacaagagcc ugaaggagca gaagaagcug aacgaccugu gcuuccugaa gagacugcug      480

caggagauca agaccugcug gaacaagauc cugaugggca ccaaggagca cuga            534


<210>  4607
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-7__Homo_sapiens__BAF84227

<400>  4607
auguuccacg ugagcuuuag auacaucuuc ggccugcccc cucucauucu gguccuucug       60

ccgguugccu ccucugacug cgauaucgag gggaaggaca gcaaacagua ugaauccgug      120

cucauggugu cuauugauca acugcuugac agcaugaagg agaucggauc caacugucug      180

aauaacgaau uuaauuucuu uaaacggcau auuugcgaug cuaacaagga gggcauguuc      240

cucuuucgcg ccgcgagaaa acugcggcag uuccugaaga ugaacucuac cggggacuuu      300

gaucuccauc ugcuuaaggu cagcgaagga acaacgaucc ugcucaauug uaccggccag      360

gugaaagggc gcaagcccgc ugcccuggga gaggcccagc cuacaaaauc ccuugaggaa      420

aauaagagcc ugaaagagca aaagaagcuc aacgaccugu gcuuccugaa aagacuccug      480

caggaaauca agaccuguug gaauaaaauu cuuaugggca caaaggagca cuga            534


<210>  4608
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-7__Homo_sapiens__BAF84227

<400>  4608
auguuccacg uaucauuuag auacauauuc ggacuacccc cacuaauacu aguacuacua       60

ccaguagcau caucagacug cgacauagaa ggaaaagacu ccaaacaaua cgaaagcgua      120

cuaaugguau caauagauca acuacuagac ucaaugaaag aaauaggauc aaacugccua      180

aacaacgaau ucaacuucuu caaaagacac aucugcgacg caaacaaaga aggaauguuc      240

cuauucagag cagcaagaaa acuacgacaa uuccuaaaaa ugaacucaac aggagacuuc      300

gaccuacacc uacuaaaagu aucagaagga acaacaauac uauuaaacug cacaggacaa      360

guaaaaggaa gaaaaccagc agcacuagga gaagcacaac caacaaaauc acuagaagaa      420

aacaaaagcc ucaaagaaca aaaaaaacua aacgaccuau gcuuccuaaa aagacuauua      480

caagaaauaa aaacaugcug gaacaaaaua cuaaugggaa caaaagaaca cuaa            534


<210>  4609
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-7__Homo_sapiens__P13232

<400>  4609

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  4610
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-7__Homo_sapiens__AAA59156

<400>  4610
auguuccaug uuucuuuuag guauaucuuu ggacuuccuc cccugauccu uguucuguug       60

ccaguagcau caucugauug ugauauugaa gguaaagaug gcaaacaaua ugagaguguu      120

cuaaugguca gcaucgauca auuauuggac agcaugaaag aaauugguag caauugccug      180

aauaaugaau uuaacuuuuu uaaaagacau aucugugaug cuaauaagga agguauguuu      240

uuauuccgug cugcucgcaa guugaggcaa uuucuuaaaa ugaauagcac uggugauuuu      300

gaucuccacu uauuaaaagu uucagaaggc acaacaauac uguugaacug cacuggccag      360

guuaaaggaa gaaaaccagc ugcccugggu gaagcccaac caacaaagag uuuggaagaa      420

aauaaaucuu uaaaggaaca gaaaaaacug aaugacuugu guuuccuaaa gagacuauua      480

caagagauaa aaacuuguug gaauaaaauu uugaugggca cuaaagaaca cuga            534


<210>  4611
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-7__Homo_sapiens__AAA59156

<400>  4611
auguuccacg ugagcuuccg cuacaucuuc ggccugcccc cgcucauccu gguccugcuc       60

cccguggccu ccagcgacug cgacaucgag gggaaggacg gcaagcagua cgaguccgug      120

cugaugguca gcaucgacca gcugcucgac uccaugaagg agaucgggag caacugccug      180

aacaacgagu ucaacuucuu caagcggcac aucugcgacg ccaacaagga gggcauguuc      240

cuguuccgcg cggcccggaa gcuccgccag uuccugaaga ugaacuccac cggggacuuc      300

gaccugcacc uccugaaggu gagcgagggc accacgaucc ugcucaacug caccggccag      360

gugaaggggc ggaagcccgc cgcccugggc gaggcccagc ccaccaaguc ccuggaggag      420

aacaagagcc ucaaggagca gaagaagcug aacgaccugu gcuuccucaa gcgccugcug      480

caggagauca agaccugcug gaacaagauc cucaugggga cgaaggagca cuga            534


<210>  4612
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-7__Homo_sapiens__AAA59156

<400>  4612
auguuccacg ucuccuuccg cuacaucuuc ggccuccccc cccucauccu cguccuccuc       60

cccgucgccu ccuccgacug cgacaucgag ggcaaggacg gcaagcagua cgaguccguc      120

cucauggucu ccaucgacca gcuccucgac uccaugaagg agaucggcuc caacugccuc      180

aacaacgagu ucaacuucuu caagcgccac aucugcgacg ccaacaagga gggcauguuc      240

cucuuccgcg ccgcccgcaa gcuccgccag uuccucaaga ugaacuccac cggcgacuuc      300

gaccuccacc uccucaaggu cuccgagggc accaccaucc uccucaacug caccggccag      360

gucaagggcc gcaagcccgc cgcccucggc gaggcccagc ccaccaaguc ccucgaggag      420

aacaaguccc ucaaggagca gaagaagcuc aacgaccucu gcuuccucaa gcgccuccuc      480

caggagauca agaccugcug gaacaagauc cucaugggca ccaaggagca cuga            534


<210>  4613
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-7__Homo_sapiens__AAA59156

<400>  4613
auguuccacg ugagcuuuag auacaucuuc ggccugcccc cucucauucu uguccuguug       60

ccaguugccu ccucugacug cgauauagag gggaaggacg gaaaacagua ugaaucagug      120

uuaaugguaa guaucgauca acugcuagac agcaugaagg agauugguuc caacugucuc      180

aauaacgaau uuaauuucuu uaaaaggcau aucugcgaug cuaacaagga gggcauguuc      240

cuguuucggg cagcccgcaa acuucgacag uuccugaaga ugaacucuac cggggacuuu      300

gauuugcacc uccugaaggu gucggaagga acaacuauuc ugcucaauug uacgggccag      360

gucaaagguc guaagccggc ggcuuuaggg gaggcccagc ccaccaaauc acuggaggaa      420

aauaagagcc uuaaagagca aaagaaguug aacgaccugu gcuuccuaaa aagacuccug      480

caggaaauca agacauguug gaauaaaaua cuuaugggaa cuaaggagca uuga            534


<210>  4614
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-7__Homo_sapiens__AAA59156

<400>  4614
auguuccacg ugagcuucag auacaucuuc ggccugcccc cccugauccu ggugcugcug       60

cccguggcca gcagcgacug cgacaucgag ggcaaggacg gcaagcagua cgagagcgug      120

cugaugguga gcaucgacca gcugcuggac agcaugaagg agaucggcag caacugccug      180

aacaacgagu ucaacuucuu caagagacac aucugcgacg ccaacaagga gggcauguuc      240

cuguucagag ccgccagaaa gcugagacag uuccugaaga ugaacagcac cggcgacuuc      300

gaccugcacc ugcugaaggu gagcgagggc accaccaucc ugcugaacug caccggccag      360

gugaagggca gaaagcccgc cgcccugggc gaggcccagc ccaccaagag ccuggaggag      420

aacaagagcc ugaaggagca gaagaagcug aacgaccugu gcuuccugaa gagacugcug      480

caggagauca agaccugcug gaacaagauc cugaugggca ccaaggagca cuga            534


<210>  4615
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-7__Homo_sapiens__AAA59156

<400>  4615
auguuccacg ugagcuuuag auacaucuuc ggccugcccc cucucauucu gguccuucug       60

ccgguugccu ccucugacug cgauaucgag gggaaggacg gaaaacagua ugaaagcgug      120

cucauggugu ccauugauca acugcuugac ucuaugaagg agaucggcag caacugucug      180

aauaacgaau uuaauuucuu uaaacggcau auuugcgaug cuaacaagga ggggauguuc      240

cucuuucgcg ccgcgagaaa acugcggcag uuccugaaga ugaacuccac cggagacuuu      300

gaucuccauc ugcuuaaggu cucugaaggc acaacgaucc ugcucaauug uaccggacag      360

gugaaagggc gcaagcccgc ugcccugggc gaggcccagc cuacaaaaag ccuugaggaa      420

aauaaguccc ugaaagagca aaagaagcuc aacgaccugu gcuuccugaa aagacuccug      480

caggaaauca agaccuguug gaauaaaauu cuuaugggca caaaggagca cuga            534


<210>  4616
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-7__Homo_sapiens__AAA59156

<400>  4616
auguuccacg uaucauucag auacauauuc ggacuaccac cacuaauacu aguacuacua       60

ccaguagcau caucagacug cgacauagaa ggaaaagacg gcaaacaaua cgaaucagua      120

cuaauggucu caauagauca auuacuagac ucaaugaaag aaauaggauc aaacugccua      180

aacaacgaau ucaacuucuu caaaagacac auaugcgacg caaacaaaga aggaauguuc      240

cuauucagag cagcaagaaa acuaagacaa uuccuaaaaa ugaacucaac aggagacuuc      300

gaccuacacu uacuaaaagu aucagaagga acaacaauac uacuaaacug cacaggacaa      360

guaaaaggaa gaaaaccagc agcacucgga gaagcacaac caacaaaauc auuagaagaa      420

aacaaaucac uaaaagaaca aaaaaaacua aacgauuuau gcuucuuaaa aagacuacua      480

caagaaauaa aaacaugcug gaacaaaaua cuaaugggaa caaaagaaca cuaa            534


<210>  4617
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-9__Homo_sapiens__P15248

<400>  4617

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 






<210>  4618
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-9__Homo_sapiens__AAA35887

<400>  4618
augcuucugg ccaugguccu uaccucugcc cugcuccugu gcuccguggc aggccagggg       60

uguccaaccu uggcggggau ccuggacauc aacuuccuca ucaacaagau gcaggaagau      120

ccagcuucca agugccacug cagugcuaau gugaccaguu gucucuguuu gggcauuccc      180

ucugacaacu gcaccagacc augcuucagu gagagacugu cucagaugac caauaccacc      240

augcaaacaa gauacccacu gauuuucagu cgggugaaaa aaucaguuga aguacuaaag      300

aacaacaagu guccauauuu uuccugugaa cagccaugca accaaaccac ggcaggcaac      360

gcgcugacau uucugaagag ucuucuggaa auuuuccaga aagaaaagau gagagggaug      420

agaggcaaga uauga                                                       435


<210>  4619
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-9__Homo_sapiens__AAA35887

<400>  4619
augcugcucg ccauggugcu gaccagcgcc cugcuccugu gcuccgucgc gggccagggg       60

ugccccaccc uggccggcau ccucgacauc aacuuccuga ucaacaagau gcaggaggac      120

ccggccagca agugccacug cuccgccaac gugacgagcu gccugugccu cgggaucccc      180

uccgacaacu gcacccgccc cugcuucagc gagcggcugu cccagaugac caacaccacg      240

augcagaccc gcuacccccu gaucuucagc cgggugaaga aguccgucga ggugcucaag      300

aacaacaagu gcccguacuu cagcugcgag cagcccugca accagaccac cgccggcaac      360

gcgcugacgu uccugaaguc ccuccuggag aucuuccaga aggagaagau gcgcgggaug      420

cggggcaaga ucuga                                                       435


<210>  4620
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-9__Homo_sapiens__AAA35887

<400>  4620
augcuccucg ccaugguccu caccuccgcc cuccuccucu gcuccgucgc cggccagggc       60

ugccccaccc ucgccggcau ccucgacauc aacuuccuca ucaacaagau gcaggaggac      120

cccgccucca agugccacug cuccgccaac gucaccuccu gccucugccu cggcaucccc      180

uccgacaacu gcacccgccc cugcuucucc gagcgccucu cccagaugac caacaccacc      240

augcagaccc gcuacccccu caucuucucc cgcgucaaga aguccgucga gguccucaag      300

aacaacaagu gccccuacuu cuccugcgag cagcccugca accagaccac cgccggcaac      360

gcccucaccu uccucaaguc ccuccucgag aucuuccaga aggagaagau gcgcggcaug      420

cgcggcaaga ucuga                                                       435


<210>  4621
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-9__Homo_sapiens__AAA35887

<400>  4621
augcugcucg ccauggugcu uaccagcgcu cuguuguuau gcuccgucgc aggccagggg       60

ugucccacac uggccggaau ccuagacauu aacuuccuca uaaauaagau gcaagaagau      120

ccugcgucua aaugccacug uucagcuaac guuacgaguu gccugugucu ugguauccca      180

agcgacaauu gcacuagacc guguuuuucc gaaaggcugu cucagaugac caacacaacu      240

augcagaccc gguaccccuu gauuuucucg cgcgugaaga aaucaguaga ggugcucaag      300

aauaacaaau gcccuuauuu uagcugugaa cagccaugca aucaaacaac cgccggcaac      360

gcacugacuu uccugaagag ucucuuagag aucuuucaga aggagaaaau gcgagggaug      420

cguggaaaga uuuga                                                       435


<210>  4622
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-9__Homo_sapiens__AAA35887

<400>  4622
augcugcugg ccauggugcu gaccagcgcc cugcugcugu gcagcguggc cggccagggc       60

ugccccaccc uggccggcau ccuggacauc aacuuccuga ucaacaagau gcaggaggac      120

cccgccagca agugccacug cagcgccaac gugaccagcu gccugugccu gggcaucccc      180

agcgacaacu gcaccagacc cugcuucagc gagagacuga gccagaugac caacaccacc      240

augcagacca gauacccccu gaucuucagc agagugaaga agagcgugga ggugcugaag      300

aacaacaagu gccccuacuu cagcugcgag cagcccugca accagaccac cgccggcaac      360

gcccugaccu uccugaagag ccugcuggag aucuuccaga aggagaagau gagaggcaug      420

agaggcaaga ucuga                                                       435


<210>  4623
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-9__Homo_sapiens__AAA35887

<400>  4623
augcugcucg ccauggugcu gaccagcgcu cugcugcucu gcuccgucgc cggccagggg       60

ugucccacac uggcgggaau ccuugacauu aacuuccuga ucaauaagau gcaagaagau      120

ccugcuucua aaugccacug uagcgccaac guuacguccu gccucugucu gggcauuccg      180

ucugacaauu gcaccagacc cuguuuuagc gaacggcugu cccagaugac aaacaccaca      240

augcagaccc gcuacccucu caucuucucu agagugaaga aaagcgugga gguccugaag      300

aauaacaaau gccccuauuu uuccugugaa cagccuugca aucaaacaac cgccgggaac      360

gcucuuacgu uccuuaagag ccuccuggag auuuuucaga aggagaaaau gcggggaaug      420

cgcggcaaga ucuga                                                       435


<210>  4624
<211>  435
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       IL-9__Homo_sapiens__AAA35887

<400>  4624
augcuacuag caaugguacu aacaucagca cuacuacuau gcucaguagc aggacaagga       60

ugcccaacau uagcaggaau auuagacaua aacuuccuaa uaaacaaaau gcaagaagac      120

ccagcaucaa aaugccacug cucagcaaac guaacaucau gccuaugccu aggaauacca      180

ucagacaacu gcacaagacc augcuucucc gaaagacuau cacaaaugac aaacacaaca      240

augcaaacac gauacccacu aauauucuca agaguaaaaa aaucaguaga aguacuaaaa      300

aacaacaaau gcccauacuu cucaugcgaa caaccaugca accaaacaac agcaggaaac      360

gcacuaacau uccuaaaauc acuacuagaa aucuuccaaa aagaaaaaau gagaggaaug      420

agaggaaaaa uauaa                                                       435


<210>  4625
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LIF__Homo_sapiens__P15018

<400>  4625

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  4626
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LIF__Homo_sapiens__AAA51699

<400>  4626
augaaggucu uggcggcagg aguugugccc cugcuguugg uucugcacug gaaacauggg       60

gcggggagcc cccuccccau caccccuguc aacgccaccu gugccauacg ccacccaugu      120

cacaacaacc ucaugaacca gaucaggagc caacuggcac agcucaaugg cagugccaau      180

gcccucuuua uucucuauua cacagcccag ggggagccgu uccccaacaa ccuggacaag      240

cuauguggcc ccaacgugac ggacuucccg cccuuccacg ccaacggcac ggagaaggcc      300

aagcuggugg agcuguaccg cauagucgug uaccuuggca ccucccuggg caacaucacc      360

cgggaccaga agauccucaa ccccagugcc cucagccucc acagcaagcu caacgccacc      420

gccgacaucc ugcgaggccu ccuuagcaac gugcugugcc gccugugcag caaguaccac      480

gugggccaug uggacgugac cuacggcccu gacaccucgg guaaggaugu cuuccagaag      540

aagaagcugg gcugucaacu ccuggggaag uauaagcaga ucaucgccgu guuggcccag      600

gccuucuag                                                              609


<210>  4627
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LIF__Homo_sapiens__AAA51699

<400>  4627
augaaggugc uggccgccgg cgucgugccc cuccugcugg ugcuccacug gaagcacggg       60

gcgggcagcc cgcugcccau cacccccguc aacgcgaccu gcgccauccg ccaccccugc      120

cacaacaacc ugaugaacca gauccggucc cagcucgccc agcugaacgg gagcgccaac      180

gcccuguuca uccucuacua cacggcccag ggcgagccgu uccccaacaa ccuggacaag      240

cugugcgggc ccaacgugac cgacuucccg cccuuccacg ccaacggcac cgagaaggcc      300

aagcucgugg agcuguaccg caucgucgug uaccugggca ccucccucgg gaacaucacg      360

cgggaccaga agauccugaa ccccagcgcg cugucccucc acagcaagcu gaacgccacc      420

gccgacaucc ugcgcggccu ccuguccaac gugcugugcc ggcucugcag caaguaccac      480

gucgggcacg uggacgugac cuacggcccc gacaccuccg ggaaggacgu cuuccagaag      540

aagaagcugg gcugccagcu gcucggcaag uacaagcaga ucaucgccgu gcuggcccag      600

gcguucuga                                                              609


<210>  4628
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LIF__Homo_sapiens__AAA51699

<400>  4628
augaaggucc ucgccgccgg cgucgucccc cuccuccucg uccuccacug gaagcacggc       60

gccggcuccc cccuccccau cacccccguc aacgccaccu gcgccauccg ccaccccugc      120

cacaacaacc ucaugaacca gauccgcucc cagcucgccc agcucaacgg cuccgccaac      180

gcccucuuca uccucuacua caccgcccag ggcgagcccu uccccaacaa ccucgacaag      240

cucugcggcc ccaacgucac cgacuucccc cccuuccacg ccaacggcac cgagaaggcc      300

aagcucgucg agcucuaccg caucgucguc uaccucggca ccucccucgg caacaucacc      360

cgcgaccaga agauccucaa ccccuccgcc cucucccucc acuccaagcu caacgccacc      420

gccgacaucc uccgcggccu ccucuccaac guccucugcc gccucugcuc caaguaccac      480

gucggccacg ucgacgucac cuacggcccc gacaccuccg gcaaggacgu cuuccagaag      540

aagaagcucg gcugccagcu ccucggcaag uacaagcaga ucaucgccgu ccucgcccag      600

gccuucuga                                                              609


<210>  4629
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LIF__Homo_sapiens__AAA51699

<400>  4629
augaaggugc uggccgcugg cgucguuccc cuccuucugg uguugcacug gaaacauggg       60

gcaggaagcc cuuuaccaau caccccggua aacgccacau gcgcgauuag acaccccugu      120

cauaauaacc ugaugaauca gauaaggucc caacuagcuc agcucaacgg uucugccaau      180

gcacuguuca uccuuuacua uacugcccag ggcgagccuu uuccaaacaa ucuggacaag      240

uugugcgggc ccaacgugac ggauuucccu ccauuucacg cuaauggaac cgaaaaagca      300

aagcucgucg agcuguaccg gauugugguu uaucugggca caucacucgg uaacaucacu      360

cgcgaccaga aaauuuuaaa ucccagugcc cugagccuuc auuccaaguu gaacgcuacc      420

gccgauaucc ugcgagggcu acucucuaau gugcuguguc gucuuugcuc gaaguaccac      480

gucggacacg uggacguaac auauggcccu gauaccucag gcaaagacgu uuuccaaaag      540

aaaaagcugg ggugucaguu gcucggaaaa uacaagcaga uaaucgcggu gcuggcacag      600

gccuuuuga                                                              609


<210>  4630
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LIF__Homo_sapiens__AAA51699

<400>  4630
augaaggugc uggccgccgg cguggugccc cugcugcugg ugcugcacug gaagcacggc       60

gccggcagcc cccugcccau cacccccgug aacgccaccu gcgccaucag acaccccugc      120

cacaacaacc ugaugaacca gaucagaagc cagcuggccc agcugaacgg cagcgccaac      180

gcccuguuca uccuguacua caccgcccag ggcgagcccu uccccaacaa ccuggacaag      240

cugugcggcc ccaacgugac cgacuucccc cccuuccacg ccaacggcac cgagaaggcc      300

aagcuggugg agcuguacag aaucguggug uaccugggca ccagccuggg caacaucacc      360

agagaccaga agauccugaa ccccagcgcc cugagccugc acagcaagcu gaacgccacc      420

gccgacaucc ugagaggccu gcugagcaac gugcugugca gacugugcag caaguaccac      480

gugggccacg uggacgugac cuacggcccc gacaccagcg gcaaggacgu guuccagaag      540

aagaagcugg gcugccagcu gcugggcaag uacaagcaga ucaucgccgu gcuggcccag      600

gccuucuga                                                              609


<210>  4631
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LIF__Homo_sapiens__AAA51699

<400>  4631
augaaggugc uggccgcugg cgucguuccc cuccugcuug ugcugcacug gaaacauggg       60

gccggaagcc cucucccgau cacccccgug aacgcgacau gcgcuauuag acacccuugu      120

cauaauaacc ugaugaauca gauccggucc caacuugccc agcugaacgg cucugccaau      180

gcucucuuca uucuguacua uacggcccag ggggagcccu uuccuaacaa ucuggacaag      240

cucugcggac ccaacgucac cgauuucccu ccguuucacg cuaauggcac agaaaaagcc      300

aagcuggugg agcuuuaccg caucguugug uaucugggga ccagccucgg aaacauuaca      360

agagaccaga aaauccugaa ucccuccgcg cuuucucugc auagcaagcu caacgccacc      420

gcugauaucc ugcggggccu gcucuccaau guccuguguc gccuuugcuc uaaguaccac      480

gugggccacg uugacgugac auaugggccu gauaccagcg gaaaagacgu cuuccaaaag      540

aaaaagcugg gcugucagcu ccuggggaaa uacaagcaga uuaucgccgu gcuugcucag      600

gccuuuuga                                                              609


<210>  4632
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LIF__Homo_sapiens__AAA51699

<400>  4632
augaaaguac uagcagccgg agucguacca cuacuauuag uacuacacug gaaacacgga       60

gcaggaucac cucuaccaau aacaccagua aacgcaacuu gcgcaauaag acacccaugc      120

cacaacaacc uaaugaacca aauaagauca caacuagcac aacuaaacgg aucagcaaac      180

gcacuauuca uauuauacua cacagcacaa ggagaaccau ucccaaacaa ccuagacaaa      240

cuaugcggac caaacguaac agacuuccca ccauuucacg caaacggaac agaaaaagca      300

aaauuaguag aacuauacag aauaguagua uaccuaggaa caucacuagg aaacauaaca      360

agagaccaaa aaauauuaaa cccaucagca cuaucacuac acucaaaacu aaacgcaaca      420

gcagacauau uaagaggacu acuauccaac guauuaugca gacuaugcuc aaaauaccac      480

guaggacaug uagacguaac auacggacca gacacaucag guaaagacgu auuccaaaaa      540

aaaaaauuag gaugccaauu acuaggaaaa uacaaacaaa uaauagcagu acuagcacaa      600

gcauuuuaa                                                              609


<210>  4633
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LIGHT__Homo_sapiens__O43557

<400>  4633

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 






<210>  4634
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LIGHT__Homo_sapiens__AAC25169

<400>  4634
auggaggaga gugucguacg gcccucagug uuuguggugg auggacagac cgacauccca       60

uucacgaggc ugggacgaag ccaccggaga cagucgugca guguggcccg ggugggucug      120

ggucucuugc uguugcugau gggggcuggg cuggccgucc aaggcugguu ccuccugcag      180

cugcacuggc gucuaggaga gauggucacc cgccugccug acggaccugc aggcuccugg      240

gagcagcuga uacaagagcg aaggucucac gaggucaacc cagcagcgca ucucacaggg      300

gccaacucca gcuugaccgg cagcgggggg ccgcuguuau gggagacuca gcugggccug      360

gccuuccuga ggggccucag cuaccacgau ggggcccuug uggucaccaa agcuggcuac      420

uacuacaucu acuccaaggu gcagcugggc ggugugggcu gcccgcuggg ccuggccagc      480

accaucaccc acggccucua caagcgcaca ccccgcuacc ccgaggagcu ggagcuguug      540

gucagccagc agucacccug cggacgggcc accagcagcu cccgggucug gugggacagc      600

agcuuccugg gugguguggu acaccuggag gcuggggaga agguggucgu ccgugugcug      660

gaugaacgcc ugguucgacu gcgugauggu acccggucuu acuucggggc uuucauggug      720

uga                                                                    723


<210>  4635
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4635
auggaggaga gcgugguccg ccccuccgug uucguggucg acggccagac cgacaucccg       60

uucacccggc uggggcgcag ccaccggcgc caguccugca gcguggcccg ggugggccuc      120

gggcugcugc uccugcugau gggcgccggg cucgcggucc agggcugguu ccugcugcag      180

cuccacuggc gccugggcga gauggugacg cggcugcccg acgggcccgc cggcuccugg      240

gagcagcuca uccaggagcg ccggagccac gaggugaacc ccgccgccca ccugaccggg      300

gccaacucca gccugaccgg cuccgggggc ccgcuccugu gggagaccca gcugggccuc      360

gcguuccugc gcgggcugag cuaccacgac ggcgcccucg ucgugacgaa ggccggguac      420

uacuacaucu acuccaaggu gcagcugggc ggcgucgggu gcccccuggg ccucgccagc      480

accaucaccc acgggcugua caagcggacg ccccgcuacc ccgaggagcu ggagcuccug      540

gugucccagc agagcccgug cggccgggcg accuccagcu cccgcgugug gugggacagc      600

uccuuccucg ggggcgucgu gcaccuggag gccggcgaga agguggucgu gcgggugcug      660

gacgagcgcc ugguccggcu ccgcgacggg acccggagcu acuucggcgc cuucauggug      720

uga                                                                    723


<210>  4636
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4636
auggaggagu ccgucguccg ccccuccguc uucgucgucg acggccagac cgacaucccc       60

uucacccgcc ucggccgcuc ccaccgccgc caguccugcu ccgucgcccg cgucggccuc      120

ggccuccucc uccuccucau gggcgccggc cucgccgucc agggcugguu ccuccuccag      180

cuccacuggc gccucggcga gauggucacc cgccuccccg acggccccgc cggcuccugg      240

gagcagcuca uccaggagcg ccgcucccac gaggucaacc ccgccgccca ccucaccggc      300

gccaacuccu cccucaccgg cuccggcggc ccccuccucu gggagaccca gcucggccuc      360

gccuuccucc gcggccucuc cuaccacgac ggcgcccucg ucgucaccaa ggccggcuac      420

uacuacaucu acuccaaggu ccagcucggc ggcgucggcu gcccccucgg ccucgccucc      480

accaucaccc acggccucua caagcgcacc ccccgcuacc ccgaggagcu cgagcuccuc      540

gucucccagc agucccccug cggccgcgcc accuccuccu cccgcgucug gugggacucc      600

uccuuccucg gcggcgucgu ccaccucgag gccggcgaga aggucgucgu ccgcguccuc      660

gacgagcgcc ucguccgccu ccgcgacggc acccgcuccu acuucggcgc cuucaugguc      720

uga                                                                    723


<210>  4637
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4637
auggaggaaa gcguggucag acccuccguu uucgugguag acggccagac cgauaucccu       60

uuuacaaggc uggggcgguc ucaccgccga caaucaugca guguggcccg ugucggacuc      120

ggucuucugu uguuacugau gggcgcuggg cuagcagugc agggaugguu ccuccugcag      180

cuucauugga gacugggcga gaugguuacu agguugccag acgguccggc cgggagcugg      240

gaacagcuca uucaagagcg gcgcucccac gaagugaacc ccgcggcuca ucugacggga      300

gccaauucuu cgcugaccgg cucaggcggg ccucucuuau gggagacaca gcugggacuu      360

gcauuuuuga gaggucugag cuaccacgau ggcgcccuag ucgugacuaa ggcuggguau      420

uacuauauau acaguaaagu acagcucgga ggcguugguu guccacuggg gcuugcaucc      480

accaucacac auggacugua uaagaggacu ccccgguacc cugaggaauu ggagcuccug      540

gugucucagc aaagcccaug cggccgcgcc accuccucaa gucgagucug gugggacagc      600

ucuuucuuag gcgggguggu gcaccuggaa gcuggagaga aagucguugu gagaguacuc      660

gaugagaggc uugugcggcu gcgugacggu acacgcuccu auuuuggcgc cuucaugguc      720

uga                                                                    723


<210>  4638
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4638
auggaggaga gcguggugag acccagcgug uucguggugg acggccagac cgacaucccc       60

uucaccagac ugggcagaag ccacagaaga cagagcugca gcguggccag agugggccug      120

ggccugcugc ugcugcugau gggcgccggc cuggccgugc agggcugguu ccugcugcag      180

cugcacugga gacugggcga gauggugacc agacugcccg acggccccgc cggcagcugg      240

gagcagcuga uccaggagag aagaagccac gaggugaacc ccgccgccca ccugaccggc      300

gccaacagca gccugaccgg cagcggcggc ccccugcugu gggagaccca gcugggccug      360

gccuuccuga gaggccugag cuaccacgac ggcgcccugg uggugaccaa ggccggcuac      420

uacuacaucu acagcaaggu gcagcugggc ggcgugggcu gcccccuggg ccuggccagc      480

accaucaccc acggccugua caagagaacc cccagauacc ccgaggagcu ggagcugcug      540

gugagccagc agagccccug cggcagagcc accagcagca gcagagugug gugggacagc      600

agcuuccugg gcggcguggu gcaccuggag gccggcgaga aggugguggu gagagugcug      660

gacgagagac uggugagacu gagagacggc accagaagcu acuucggcgc cuucauggug      720

uga                                                                    723


<210>  4639
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4639
auggaggaaa gcguggucag acccuccguu uucguggugg acggccagac cgauaucccu       60

uuuacacggc uggggcgcuc ucacagacgg caaagcugcu ccgucgcccg cgugggacuc      120

ggccugcuuc ugcuccugau gggggcugga cuugccguuc agggcugguu ccugcuccag      180

cugcauugga gacuggggga gauggugacg cggcucccgg acggacccgc gggcucuugg      240

gaacagcuga uucaagagcg cagaagccac gaagucaacc cugcugccca ucuuaccggc      300

gccaauuccu cucugacagg gagcggaggc ccccuccugu gggagaccca gcuugggcug      360

gcuuuucucc ggggacuguc cuaccacgau ggcgcccugg ugguuacaaa ggcuggguau      420

uacuauaucu acagcaaagu gcagcucgga ggcgucggcu guccucuggg gcuugccucu      480

accauuacac auggacugua uaagcgcacc cccagauacc cugaggaacu cgagcugcuu      540

gugucccagc aaagcccgug cggccgggcg acgucuucca gccgcgugug gugggacucu      600

uccuuccucg ggggagucgu ucaccuggaa gccggcgaga aagugguggu cagagugcug      660

gaugagcggc ugguucgccu cagagacggg acccggagcu auuuuggagc uuucauggug      720

uga                                                                    723


<210>  4640
<211>  723
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LIGHT__Homo_sapiens__AAC25169

<400>  4640
auggaagaaa guguaguaag accaaguguu uuuguaguag auggacaaac agauauacca       60

uuuacaagau uaggaagauc acaucgaaga caaaguugua guguggcaag aguaggauua      120

ggauuauuau uauuacuaau gggugcggga uuagcaguac aaggaugguu uuuauuacaa      180

uugcauugga gguuagguga aauggugacu agauuaccgg acggaccugc aggaaguugg      240

gaacaacuaa uacaagaaag aagaucacac gaaguaaauc cagcagcaca ccuaacagga      300

gcaaauaguu cauuaacagg aaguggaggu ccauuguuau gggaaacaca auuagguuua      360

gcauuuuuaa gaggauuaag uuaucaugau ggagcauuag uaguaacaaa agcaggauau      420

uauuauauau auucaaaagu acaauuagga ggaguugggu guccauuagg auuagcgagc      480

acgauaacac auggauuaua caaaaggaca ccaagauauc cugaagaauu agaauuacua      540

guaagucaac aaucaccaug uggaagagca acaaguucaa guagaguaug gugggauagu      600

ucauuucuag gaggaguagu acauuuagaa gcaggagaaa aaguaguugu aagaguauua      660

gaugaaaggu uaguaagacu aagagauggu acaagaucau auuuuggagc auuuauggua      720

uaa                                                                    723


<210>  4641
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__B4DVZ8

<400>  4641

Met Pro Glu Ile Val Asp Thr Lys Asp Leu Thr Ile Glu Lys Val Val 
1               5                   10                  15      


Ile Asn Gly Gln Glu Val Lys Tyr Ala Leu Gly Glu Arg Gln Ser Tyr 
            20                  25                  30          


Lys Gly Ser Pro Met Glu Ile Ser Leu Pro Ile Ala Leu Ser Lys Asn 
        35                  40                  45              


Gln Glu Ile Val Ile Glu Ile Ser Phe Glu Thr Ser Pro Lys Ser Ser 
    50                  55                  60                  


Ala Leu Gln Trp Leu Thr Pro Glu Gln Thr Ser Gly Lys Glu His Pro 
65                  70                  75                  80  


Tyr Leu Phe Ser Gln Cys Gln Ala Ile His Cys Arg Ala Ile Leu Pro 
                85                  90                  95      


Cys Gln Asp Thr Pro Ser Val Lys Leu Thr Tyr Thr Ala Glu Val Ser 
            100                 105                 110         


Val Pro Lys Glu Leu Val Ala Leu Met Ser Ala Ile Arg Asp Gly Glu 
        115                 120                 125             


Thr Pro Asp Pro Glu Asp Pro Ser Arg Lys Ile Tyr Lys Phe Ile Gln 
    130                 135                 140                 


Lys Val Pro Ile Pro Cys Tyr Leu Ile Ala Leu Val Val Gly Ala Leu 
145                 150                 155                 160 


Glu Ser Arg Gln Ile Gly Pro Arg Thr Leu Val Trp Ser Glu Lys Glu 
                165                 170                 175     


Gln Val Glu Lys Ser Ala Tyr Glu Phe Ser Glu Thr Glu Ser Met Leu 
            180                 185                 190         


Lys Ile Ala Glu Asp Leu Gly Gly Pro Tyr Val Trp Gly Gln Tyr Asp 
        195                 200                 205             


Leu Leu Val Leu Pro Pro Ser Phe Pro Tyr Gly Gly Met Glu Asn Pro 
    210                 215                 220                 


Cys Leu Thr Phe Val Thr Pro Thr Leu Leu Ala Gly Asp Lys Ser Leu 
225                 230                 235                 240 


Ser Asn Val Ile Ala His Glu Ile Ser His Ser Trp Thr Gly Asn Leu 
                245                 250                 255     


Val Thr Asn Lys Thr Trp Asp His Phe Trp Leu Asn Glu Gly His Thr 
            260                 265                 270         


Val Tyr Leu Glu Arg His Ile Cys Gly Arg Leu Phe Gly Glu Lys Phe 
        275                 280                 285             


Arg His Phe Asn Ala Leu Gly Gly Trp Gly Glu Leu Gln Asn Ser Val 
    290                 295                 300                 


Lys Thr Phe Gly Glu Thr His Pro Phe Thr Lys Leu Val Val Asp Leu 
305                 310                 315                 320 


Thr Asp Ile Asp Pro Asp Val Ala Tyr Ser Ser Val Pro Tyr Glu Lys 
                325                 330                 335     


Gly Phe Ala Leu Leu Phe Tyr Leu Glu Gln Leu Leu Gly Gly Pro Glu 
            340                 345                 350         


Ile Phe Leu Gly Phe Leu Lys Ala Tyr Val Glu Lys Phe Ser Tyr Lys 
        355                 360                 365             


Ser Ile Thr Thr Asp Asp Trp Lys Asp Phe Leu Tyr Ser Tyr Phe Lys 
    370                 375                 380                 


Asp Lys Val Asp Val Leu Asn Gln Val Asp Trp Asn Ala Trp Leu Tyr 
385                 390                 395                 400 


Ser Pro Gly Leu Pro Pro Ile Lys Pro Asn Tyr Asp Met Thr Leu Thr 
                405                 410                 415     


Asn Ala Cys Ile Ala Leu Ser Gln Arg Trp Ile Thr Ala Lys Glu Asp 
            420                 425                 430         


Asp Leu Asn Ser Phe Asn Ala Thr Asp Leu Lys Asp Leu Ser Ser His 
        435                 440                 445             


Gln Leu Asn Glu Phe Leu Ala Gln Thr Leu Gln Arg Ala Pro Leu Pro 
    450                 455                 460                 


Leu Gly His Ile Lys Arg Met Gln Glu Val Tyr Asn Phe Asn Ala Ile 
465                 470                 475                 480 


Asn Asn Ser Glu Ile Arg Phe Arg Trp Leu Arg Leu Cys Ile Gln Ser 
                485                 490                 495     


Lys Trp Glu Asp Ala Ile Pro Leu Ala Leu Lys Met Ala Thr Glu Gln 
            500                 505                 510         


Gly Arg Met Lys Phe Thr Arg Pro Leu Phe Lys Asp Leu Ala Ala Phe 
        515                 520                 525             


Asp Lys Ser His Asp Gln Ala Val Arg Thr Tyr Gln Glu His Lys Ala 
    530                 535                 540                 


Ser Met His Pro Val Thr Ala Met Leu Val Gly Lys Asp Leu Lys Val 
545                 550                 555                 560 


Asp 
    


<210>  4642
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__BAG62860

<400>  4642
augcccgaga uaguggauac aaaggaccuu acaauagaaa aaguagugau caauggacaa       60

gaagucaaau augcucuugg agaaagacaa aguuacaagg gaucgccaau ggaaaucucu      120

cuuccuaucg cuuugagcaa aaaucaagaa auuguuauag aaauuucuuu ugagaccucu      180

ccaaaaucuu cugcucucca guggcucacu ccugaacaga cuucugggaa ggaacaccca      240

uaucucuuua gucagugcca ggccauccac ugcagagcaa uccuuccuug ucaggacacu      300

ccuucuguga aauuaaccua uacugcagag gugucugucc cuaaagaacu gguggcacuu      360

augagugcua uucgugaugg agaaacaccu gacccagaag acccaagcag gaaaauauac      420

aaauucaucc aaaaaguucc aauacccugc uaccugauug cuuuaguugu uggagcuuua      480

gaaagcaggc aaauuggccc aagaacuuug guguggucug agaaagagca gguggaaaag      540

ucugcuuaug aguuuucuga gacugaaucu augcuuaaaa uagcagaaga ucugggagga      600

ccguauguau ggggacagua ugaccuauug guccugccac cauccuuccc uuaugguggc      660

auggagaauc cuugccuuac uuuuguaacu ccuacucuac uggcaggcga caagucacuc      720

uccaauguca uugcacauga aauaucucau agcuggacag ggaaucuagu gaccaacaaa      780

acuugggauc acuuuugguu aaaugaggga cauacugugu acuuggaacg ccacauuugc      840

ggacgauugu uuggugaaaa guucagacau uuuaaugcuc ugggaggaug gggagaacua      900

cagaauucgg uaaagacauu uggggagaca cauccuuuca ccaaacuugu gguugaucug      960

acagauauag acccugaugu agcuuauucu ucaguucccu augagaaggg cuuugcuuua     1020

cuuuuuuacc uugaacaacu gcuuggagga ccagagauuu uccuaggauu cuuaaaagcu     1080

uauguugaga aguuuuccua uaagagcaua acuacugaug acuggaagga uuuccuguau     1140

uccuauuuua aagauaaggu ugauguucuc aaucaaguug auuggaaugc cuggcucuac     1200

ucuccuggac ugccucccau aaagcccaau uaugauauga cucugacaaa ugcuuguauu     1260

gccuuaaguc aaagauggau uacugccaaa gaagaugauu uaaauucauu caaugccaca     1320

gaccugaagg aucucucuuc ucaucaauug aaugaguuuu uagcacagac gcuccagagg     1380

gcaccucuuc cauuggggca cauaaagcga augcaagagg uguacaacuu caaugccauu     1440

aacaauucug aaauacgauu cagauggcug cggcucugca uucaauccaa gugggaggac     1500

gcaauuccuu uggcgcuaaa gauggcaacu gaacaaggaa gaaugaaguu uacccggccc     1560

uuauucaagg aucuugcugc cuuugacaaa ucccaugauc aagcuguccg aaccuaccaa     1620

gagcacaaag caagcaugca ucccgugacu gcaaugcugg uggggaaaga cuuaaaagug     1680

gauuaa                                                                1686


<210>  4643
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4643
augcccgaga ucguggacac caaggaccug accaucgaga aggucgugau caacggccag       60

gaggugaagu acgcccucgg ggagcgccag agcuacaagg gcuccccgau ggagaucagc      120

cugcccaucg cccuguccaa gaaccaggag aucgucaucg agaucagcuu cgagacgucc      180

cccaagagcu ccgcgcucca guggcugacc cccgagcaga ccagcgggaa ggagcacccg      240

uaccuguucu cccagugcca ggccauccac ugccgggcca uccuccccug ccaggacacc      300

cccagcguga agcugacgua caccgccgag guguccgucc ccaaggagcu gguggcccuc      360

augagcgcga uccgcgacgg cgagaccccg gaccccgagg accccucccg gaagaucuac      420

aaguucaucc agaaggugcc caucccgugc uaccugaucg cccuggucgu gggggcccuc      480

gagagccgcc agaucggccc ccggacccug gugugguccg agaaggagca ggucgagaag      540

uccgccuacg aguucagcga gacggagagc augcugaaga ucgcggagga ccucggcggg      600

cccuacgugu ggggccagua cgaccugcug gugcugcccc cguccuuccc cuacgggggc      660

auggagaacc ccugccugac cuucgucacc cccacccugc ucgccgggga caagagccug      720

agcaacguga ucgcccacga gaucucccac agcuggacgg gcaaccuggu gaccaacaag      780

accugggacc acuucuggcu caacgagggc cacaccgucu accuggagcg ccacaucugc      840

gggcggcugu ucggcgagaa guuccgccac uucaacgccc ucgggggcug gggcgagcug      900

cagaacuccg ugaagacguu cggggagacc cacccguuca ccaagcuggu ggucgaccuc      960

accgacaucg accccgacgu ggccuacagc uccgugcccu acgagaaggg cuucgcgcug     1020

cuguucuacc ucgagcagcu gcucgggggc cccgagaucu uccucggguu ccugaaggcc     1080

uacgucgaga aguucagcua caaguccauc acgaccgacg acuggaagga cuuccuguac     1140

agcuacuuca aggacaaggu ggacguccuc aaccaggugg acuggaacgc cuggcuguac     1200

uccccgggcc ugccgcccau caagcccaac uacgacauga cccucaccaa cgccugcauc     1260

gcccugagcc agcgguggau cacggcgaag gaggacgacc ugaacuccuu caacgccacc     1320

gaccucaagg accugagcuc ccaccagcug aacgaguucc ucgcccagac ccugcagcgc     1380

gcgccccugc cccugggcca caucaagcgg augcaggagg uguacaacuu caacgccauc     1440

aacaacagcg agauccgcuu ccgguggcuc cgccugugca uccaguccaa gugggaggac     1500

gccauccccc uggcccucaa gauggccacc gagcaggggc ggaugaaguu cacgcgcccg     1560

cuguucaagg accuggccgc cuucgacaag agccacgacc aggcgguccg gaccuaccag     1620

gagcacaagg ccuccaugca ccccgugacc gccaugcucg ugggcaagga ccugaagguc     1680

gacuga                                                                1686


<210>  4644
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4644
augcccgaga ucgucgacac caaggaccuc accaucgaga aggucgucau caacggccag       60

gaggucaagu acgcccucgg cgagcgccag uccuacaagg gcucccccau ggagaucucc      120

cuccccaucg cccucuccaa gaaccaggag aucgucaucg agaucuccuu cgagaccucc      180

cccaaguccu ccgcccucca guggcucacc cccgagcaga ccuccggcaa ggagcacccc      240

uaccucuucu cccagugcca ggccauccac ugccgcgcca uccuccccug ccaggacacc      300

cccuccguca agcucaccua caccgccgag gucuccgucc ccaaggagcu cgucgcccuc      360

auguccgcca uccgcgacgg cgagaccccc gaccccgagg accccucccg caagaucuac      420

aaguucaucc agaagguccc cauccccugc uaccucaucg cccucgucgu cggcgcccuc      480

gagucccgcc agaucggccc ccgcacccuc gucugguccg agaaggagca ggucgagaag      540

uccgccuacg aguucuccga gaccgagucc augcucaaga ucgccgagga ccucggcggc      600

cccuacgucu ggggccagua cgaccuccuc guccuccccc ccuccuuccc cuacggcggc      660

auggagaacc ccugccucac cuucgucacc cccacccucc ucgccggcga caagucccuc      720

uccaacguca ucgcccacga gaucucccac uccuggaccg gcaaccucgu caccaacaag      780

accugggacc acuucuggcu caacgagggc cacaccgucu accucgagcg ccacaucugc      840

ggccgccucu ucggcgagaa guuccgccac uucaacgccc ucggcggcug gggcgagcuc      900

cagaacuccg ucaagaccuu cggcgagacc caccccuuca ccaagcucgu cgucgaccuc      960

accgacaucg accccgacgu cgccuacucc uccguccccu acgagaaggg cuucgcccuc     1020

cucuucuacc ucgagcagcu ccucggcggc cccgagaucu uccucggcuu ccucaaggcc     1080

uacgucgaga aguucuccua caaguccauc accaccgacg acuggaagga cuuccucuac     1140

uccuacuuca aggacaaggu cgacguccuc aaccaggucg acuggaacgc cuggcucuac     1200

ucccccggcc ucccccccau caagcccaac uacgacauga cccucaccaa cgccugcauc     1260

gcccucuccc agcgcuggau caccgccaag gaggacgacc ucaacuccuu caacgccacc     1320

gaccucaagg accucuccuc ccaccagcuc aacgaguucc ucgcccagac ccuccagcgc     1380

gccccccucc cccucggcca caucaagcgc augcaggagg ucuacaacuu caacgccauc     1440

aacaacuccg agauccgcuu ccgcuggcuc cgccucugca uccaguccaa gugggaggac     1500

gccauccccc ucgcccucaa gauggccacc gagcagggcc gcaugaaguu cacccgcccc     1560

cucuucaagg accucgccgc cuucgacaag ucccacgacc aggccguccg caccuaccag     1620

gagcacaagg ccuccaugca ccccgucacc gccaugcucg ucggcaagga ccucaagguc     1680

gacuga                                                                1686


<210>  4645
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4645
augcccgaga ucguggacac caaggaucug acaauugaaa aagucguuau aaacggccag       60

gaggugaagu acgcccucgg ggaaagacaa agcuauaaag gauccccuau ggagaucucu      120

cuuccaauug cucugucaaa gaaucaggaa aucguaauug agaucaguuu cgagacuagc      180

ccgaaauccu cugcauugca gugguuaacg cccgaacaga ccucggguaa ggagcacccu      240

uaccuguuuu cacaaugcca ggccauacau uguagggcga uccuaccaug ccaggacaca      300

cccagcguga agcucacuua uaccgcugaa gucagugugc cuaaagagcu gguugcccuu      360

auguccgcaa uucgggaugg cgagacacca gaccccgaag auccuucucg caagaucuac      420

aaauucauuc agaaggugcc aaucccgugu uaucugauag ccuuggucgu gggggcucuc      480

gagagccgac aaauuggacc ccguacccug guaugguccg aaaaagagca gguugaaaag      540

ucagcauacg aguuuaguga gacugaaagc augcugaaga ucgccgagga ccucggcggu      600

ccuuaugugu gggggcagua cgauuuacug guccuuccac ccucuuuccc uuacggaggc      660

auggaaaacc caugcuugac auuugugacc cccacgcugc uagcuggcga caaaucccuc      720

ucaaauguga uugcccacga gaucagccau aguuggacug ggaaccuggu caccaauaag      780

acaugggauc acuucuggcu uaacgaagga cauacuguuu aucuggagag acacaucugu      840

gguagguugu uuggcgagaa auuccggcac uuuaaugcgc ucgggggaug gggcgaacug      900

cagaacucug ugaagaccuu cggugagaca cauccguuua ccaaauuagu aguggaccug      960

acggauauug acccugaugu cgcauacucc agcgugcccu augaaaaggg guucgcccuc     1020

cuguuuuacc uugagcaauu gcuaggaggc ccagaaauau uccugggcuu ccucaaggcu     1080

uauguugaga aauuuucgua caagucuauc acuacagacg acuggaaaga uuuccuguau     1140

uccuacuuua aggacaaagu ggauguccuu aaucaggugg acuggaacgc cuggcuguac     1200

ucaccugggu ugcccccaau uaagcccaau uaugauauga cccucacuaa cgcaugcauc     1260

gcucugaguc agcgcuggau aacagccaaa gaggacgauu uaaauagcuu caacgcgacc     1320

gaccugaagg aucuauccuc ucaccaacuc aaugaauuuc uggcccagac gcuucagaga     1380

gcaccuuugc cacugggaca uauuaagagg augcaggagg uauacaacuu caacgcuauc     1440

aauaacagcg aaauccgguu ucgcuggcuc cgacugugua uucaaucaaa augggaggac     1500

gccaucccgc uugcucugaa gauggccacc gagcagggua gaaugaaauu cacaaggccc     1560

uuguuuaagg aucucgcagc cuucgacaaa agucacgacc aggcuguucg gacuuaucag     1620

gaacacaagg cguccaugca uccugugacc gcaaugcugg ucggcaagga uuuaaaagug     1680

gacuga                                                                1686


<210>  4646
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4646
augcccgaga ucguggacac caaggaccug accaucgaga agguggugau caacggccag       60

gaggugaagu acgcccuggg cgagagacag agcuacaagg gcagccccau ggagaucagc      120

cugcccaucg cccugagcaa gaaccaggag aucgugaucg agaucagcuu cgagaccagc      180

cccaagagca gcgcccugca guggcugacc cccgagcaga ccagcggcaa ggagcacccc      240

uaccuguuca gccagugcca ggccauccac ugcagagcca uccugcccug ccaggacacc      300

cccagcguga agcugaccua caccgccgag gugagcgugc ccaaggagcu gguggcccug      360

augagcgcca ucagagacgg cgagaccccc gaccccgagg accccagcag aaagaucuac      420

aaguucaucc agaaggugcc cauccccugc uaccugaucg cccugguggu gggcgcccug      480

gagagcagac agaucggccc cagaacccug guguggagcg agaaggagca gguggagaag      540

agcgccuacg aguucagcga gaccgagagc augcugaaga ucgccgagga ccugggcggc      600

cccuacgugu ggggccagua cgaccugcug gugcugcccc ccagcuuccc cuacggcggc      660

auggagaacc ccugccugac cuucgugacc cccacccugc uggccggcga caagagccug      720

agcaacguga ucgcccacga gaucagccac agcuggaccg gcaaccuggu gaccaacaag      780

accugggacc acuucuggcu gaacgagggc cacaccgugu accuggagag acacaucugc      840

ggcagacugu ucggcgagaa guucagacac uucaacgccc ugggcggcug gggcgagcug      900

cagaacagcg ugaagaccuu cggcgagacc caccccuuca ccaagcuggu gguggaccug      960

accgacaucg accccgacgu ggccuacagc agcgugcccu acgagaaggg cuucgcccug     1020

cuguucuacc uggagcagcu gcugggcggc cccgagaucu uccugggcuu ccugaaggcc     1080

uacguggaga aguucagcua caagagcauc accaccgacg acuggaagga cuuccuguac     1140

agcuacuuca aggacaaggu ggacgugcug aaccaggugg acuggaacgc cuggcuguac     1200

agccccggcc ugccccccau caagcccaac uacgacauga cccugaccaa cgccugcauc     1260

gcccugagcc agagauggau caccgccaag gaggacgacc ugaacagcuu caacgccacc     1320

gaccugaagg accugagcag ccaccagcug aacgaguucc uggcccagac ccugcagaga     1380

gccccccugc cccugggcca caucaagaga augcaggagg uguacaacuu caacgccauc     1440

aacaacagcg agaucagauu cagauggcug agacugugca uccagagcaa gugggaggac     1500

gccauccccc uggcccugaa gauggccacc gagcagggca gaaugaaguu caccagaccc     1560

cuguucaagg accuggccgc cuucgacaag agccacgacc aggccgugag aaccuaccag     1620

gagcacaagg ccagcaugca ccccgugacc gccaugcugg ugggcaagga ccugaaggug     1680

gacuga                                                                1686


<210>  4647
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4647
augcccgaga ucguggacac caaggaucug acaauugaaa aagucguuau caacggccag       60

gaggugaagu acgcccucgg ggaaagacaa agcuauaaag gauccccuau ggagauuucu      120

cugccgaucg cucuuagcaa gaaucaggaa auugugaucg agaucuccuu cgagacgucu      180

cccaaaagcu ccgcccugca guggcucacc ccugaacaga caucuggcaa ggagcacccc      240

uaccuguuua gccaaugcca ggcgauucau ugucgggcua uccuuccuug ccaggacacc      300

cccuccguca agcugacaua uaccgccgaa gugagcguuc cuaaagagcu cguggcccug      360

augucugcua uucgcgaugg ggagacaccg gaccccgaag auccuuccag aaagaucuac      420

aaauucauuc agaagguccc caucccuugu uaucugauug cccucguggu uggagcucug      480

gagagccggc aaaucggccc ccgcacccuu guguggucug aaaaagagca ggucgaaaag      540

uccgccuacg aguuuagcga gacggaaucu augcugaaga ucgcggagga ccucggggga      600

ccguaugugu ggggccagua cgaucugcuu gugcugccuc ccuccuuccc uuacggcggg      660

auggaaaacc ccugccucac cuuugucaca cccacccugc uggccggaga caaaagccuc      720

uccaauguua uugcucacga gaucucucau agcuggacag gcaaccuggu gaccaauaag      780

acgugggauc acuucuggcu uaacgaaggg cauacagugu aucuggagag acacauuugu      840

ggacggcucu uuggcgagaa auuccgccac uuuaaugccc uugggggaug gggcgaacug      900

cagaacuccg ucaagaccuu cggcgagaca cauccuuuua ccaaacuggu gguugaccuc      960

accgauaucg acccggaugu ggcuuacagc ucuguccccu augaaaaggg guucgcccug     1020

cuguuuuacc ucgagcaacu gcuuggaggc ccugaaauuu uccugggguu ccucaaagcg     1080

uauguggaga aguuuuccua caagagcauc acaacggacg acuggaaaga uuuccuguau     1140

ucuuacuuua aggacaaagu ugaugugcuu aaucaggucg acuggaacgc cuggcuguac     1200

agccccggac ucccucccau caagccgaau uaugauauga cccugacaaa cgcuugcauu     1260

gcccuguccc agagauggau caccgcuaaa gaggacgauc ucaauucuuu caacgccaca     1320

gaccugaagg aucuuagcuc ccaccaacug aaugaauuuc ucgcccagac ccugcagcgg     1380

gcuccucugc cccuuggcca uauuaagcgc augcaggagg uguacaacuu caacgcgauc     1440

aauaacagcg aaauuagauu ucgguggcuc cgccugugua uccaaucuaa augggaggac     1500

gccaucccuc uggcucucaa gauggccacg gagcagggga gaaugaaauu cacacggccc     1560

cuguuuaagg aucuugccgc uuucgacaaa ucccacgacc aggccguccg caccuaucag     1620

gaacacaagg cgagcaugca uccugugacc gcuaugcugg uuggaaagga ucucaaagug     1680

gacuga                                                                1686


<210>  4648
<211>  1686
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__BAG62860

<400>  4648
augccagaaa uaguagacac aaaagaccuc acaauagaaa aaguugucau aaauggacaa       60

gaagucaaau augcacucgg agaaagacaa ucauacaaag gaucaccaau ggaaauauca      120

uuaccaauag cauuaaguaa aaaccaagaa aucguaauag aaauaaguuu cgaaacaucu      180

ccaaaaucau ccgccuuaca auggcugacc ccggaacaaa caucaggaaa agaacaucca      240

uaccuauuuu cacaauguca agcaauacac ugcagagcua uacuaccaug ccaagacaca      300

ccaucaguaa aacuaacaua uaccgcagaa gucucagucc caaaagaauu aguugcacua      360

auguccgcaa uaagagacgg ugaaacaccu gauccagaag acccaucucg aaaaauauac      420

aaauucauac aaaaaguacc aaucccaugc uauuuaauag cacucguagu aggagcacuc      480

gaaagccgac agauaggccc acgaacacua guauggucag aaaaagaaca aguagaaaaa      540

ucagcauacg aauuuucaga aacagaauca augcuaaaaa uagcagaaga ccucggggga      600

ccauacgugu ggggacaaua cgaccuucua guacuaccac caaguuuccc auacggagga      660

auggaaaauc ccugucucac cuuuguaaca ccaaccuuau uagcaggaga uaaaucacug      720

agcaauguaa uagcgcauga aauaucacac ucauggacag gaaaucucgu aacaaauaaa      780

acaugggauc auuuuuggcu aaacgaaggu cacacaguuu aucuugaacg acauauuugc      840

ggacgucuau ucggagaaaa auuuagacac uucaaugcau uaggaggaug gggagaacuu      900

caaaacucgg uaaaaaccuu uggagaaaca cacccauuca ccaaacuagu agucgauuua      960

acagauauag auccagacgu agcauauuca aguguaccau acgaaaaagg auucgcacuc     1020

cuauucuacc ucgagcaacu ccucgguggc ccugaaauau uucuaggauu cuuaaaagca     1080

uauguagaaa aauuuagcua caaaucgaua acaacagaug auuggaaaga uuuccuuuau     1140

uccuacuuca aagacaaagu agacguauua aaccaagucg auuggaacgc auggcuauac     1200

uccccagguu uaccaccuau aaaaccaaac uacgauauga cucucacaaa cgcuugcaua     1260

gcacucucac aaagauggau cacugcaaaa gaagacgacc uaaauuccuu caacgcaaca     1320

gacuuaaaag accucagcuc acaccaauua aacgaauucc ucgcacaaac gcuccaaaga     1380

gcacccuuac cauuggguca cauaaaacga augcaagaag uauacaacuu caacgcuaua     1440

aacaacuccg aaaucagauu ccgauggcua agauuaugua uccaaucaaa augggaagac     1500

gcaauaccac uagccuuaaa aauggcaacu gaacaaggac gaaugaaauu cacuagaccc     1560

uuauucaaag acuuagcagc auucgacaaa ucacaugacc aggcaguaag aacauaccaa     1620

gaacacaaag cuucuaugca ccccguaacu gcaauguuag uaggaaaaga ucucaaaguc     1680

gacuaa                                                                1686


<210>  4649
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__P01374

<400>  4649

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  4650
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__AAA61199

<400>  4650
augacaccac cugaacgucu cuuccuccca agggugugug gcaccacccu acaccuccuc       60

cuucuggggc ugcugcuggu ucugcugccu ggggcccagg ggcucccugg uguuggccuc      120

acaccuucag cugcccagac ugcccgucag caccccaaga ugcaucuugc ccacagcacc      180

cucaaaccug cugcucaccu cauuggagac cccagcaagc agaacucacu gcucuggaga      240

gcaaacacgg accgugccuu ccuccaggau gguuucuccu ugagcaacaa uucucuccug      300

guccccacca guggcaucua cuucgucuac ucccaggugg ucuucucugg gaaagccuac      360

ucucccaagg ccaccuccuc cccacucuac cuggcccaug agguccagcu cuucuccucc      420

caguaccccu uccaugugcc ucuccucagc ucccagaaga ugguguaucc agggcugcag      480

gaacccuggc ugcacucgau guaccacggg gcugcguucc agcucaccca gggagaccag      540

cuauccaccc acacagaugg caucccccac cuaguccuca gcccuaguac ugucuucuuu      600

ggagccuucg cucuguag                                                    618


<210>  4651
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4651
augacgcccc cggagcgccu guuccucccc cgggugugcg gcaccacccu gcaccuccuc       60

cugcuggggc uccugcuggu ccuccugccc ggcgcccagg ggcugcccgg cguggggcuc      120

accccgagcg ccgcgcagac cgcccgccag caccccaaga ugcaccuggc ccacuccacc      180

cugaagcccg ccgcccaccu caucggcgac cccagcaagc agaacucccu gcuguggcgg      240

gcgaacacgg accgcgccuu ccuccaggac ggcuucagcc uguccaacaa cagccugcuc      300

gugccgaccu ccgggaucua cuucgucuac agccaggugg uguucuccgg caaggccuac      360

agccccaagg ccaccuccag cccccuguac cuggcgcacg agguccagcu guucuccagc      420

caguaccccu uccacgugcc gcugcugucc agccagaaga ugguguaccc cgggcuccag      480

gagcccuggc ugcacuccau guaccacggc gccgccuucc agcugaccca gggggaccag      540

cucagcacgc acaccgacgg caucccccac cugguccugu ccccgagcac cguguucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4652
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4652
augacccccc ccgagcgccu cuuccucccc cgcgucugcg gcaccacccu ccaccuccuc       60

cuccucggcc uccuccucgu ccuccucccc ggcgcccagg gccuccccgg cgucggccuc      120

acccccuccg ccgcccagac cgcccgccag caccccaaga ugcaccucgc ccacuccacc      180

cucaagcccg ccgcccaccu caucggcgac cccuccaagc agaacucccu ccucuggcgc      240

gccaacaccg accgcgccuu ccuccaggac ggcuucuccc ucuccaacaa cucccuccuc      300

guccccaccu ccggcaucua cuucgucuac ucccaggucg ucuucuccgg caaggccuac      360

ucccccaagg ccaccuccuc cccccucuac cucgcccacg agguccagcu cuucuccucc      420

caguaccccu uccacguccc ccuccucucc ucccagaaga uggucuaccc cggccuccag      480

gagcccuggc uccacuccau guaccacggc gccgccuucc agcucaccca gggcgaccag      540

cucuccaccc acaccgacgg caucccccac cucguccucu cccccuccac cgucuucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4653
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4653
augacacccc cugagagacu guuccuccca agggugugcg gcaccacucu ucaccuguug       60

uuacuggggc uacuccuggu ccuucugccg ggagcccagg guuugcccgg cguugggcuc      120

acgccuagcg cugcacaaac cgcccggcag cauccaaaga ugcaccuggc gcauuccaca      180

cugaaacccg cugcccaccu caucggagac ccuucuaagc agaacucauu acuguggcgc      240

gcaaauacug aucgagccuu ucuucaggac ggcuucaguu ugagcaacaa uucccugcua      300

gugccaaccu cugguauuua cuuuguauau ucgcaagugg ucuucucagg gaaggcuuac      360

agccccaaag caacaaguuc cccucucuau cuggcccaug aagugcagcu guuuucuagc      420

caguacccau uccacguucc gcuuuugucc ucacagaaaa ugguguaucc cggacuccaa      480

gagccuuggc ugcacaguau guaccauggc gcugccuuuc aguuaaccca gggcgaucag      540

cugagcacuc acacagacgg gauaccacau cucguccuuu cucccuccac cguguucuuu      600

ggagcguucg cacuguga                                                    618


<210>  4654
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4654
augacccccc ccgagagacu guuccugccc agagugugcg gcaccacccu gcaccugcug       60

cugcugggcc ugcugcuggu gcugcugccc ggcgcccagg gccugcccgg cgugggccug      120

acccccagcg ccgcccagac cgccagacag caccccaaga ugcaccuggc ccacagcacc      180

cugaagcccg ccgcccaccu gaucggcgac cccagcaagc agaacagccu gcuguggaga      240

gccaacaccg acagagccuu ccugcaggac ggcuucagcc ugagcaacaa cagccugcug      300

gugcccacca gcggcaucua cuucguguac agccaggugg uguucagcgg caaggccuac      360

agccccaagg ccaccagcag cccccuguac cuggcccacg aggugcagcu guucagcagc      420

caguaccccu uccacgugcc ccugcugagc agccagaaga ugguguaccc cggccugcag      480

gagcccuggc ugcacagcau guaccacggc gccgccuucc agcugaccca gggcgaccag      540

cugagcaccc acaccgacgg caucccccac cuggugcuga gccccagcac cguguucuuc      600

ggcgccuucg cccuguga                                                    618


<210>  4655
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4655
augacacccc cugagagacu guuccucccg cgggugugcg gcaccacgcu gcaccuucug       60

cuccuggggc uucugcucgu ccugcugccc ggagcccagg gccucccugg gguuggacug      120

acccccagcg cugcccaaac agcgcgccag cauccuaaga ugcaccuugc ucauuccacc      180

cugaaacccg ccgcccaccu caucggcgac ccuucuaagc agaacagccu gcuuuggaga      240

gcuaauacag aucgggccuu ucugcaggac ggguucuccc ucucuaacaa uagccugcug      300

gugccgaccu ccggaauuua cuuuguguau ucucaagucg uguucagcgg caaggcuuac      360

ucccccaaag ccacaagcuc uccucucuau cuggcgcaug aaguucagcu guuuuccagc      420

caguaccccu uccacgugcc ucuucucucu ucccagaaaa uggucuaucc cggccugcaa      480

gagccguggc uucacagcau guaccauggg gccgcuuuuc agcugaccca gggagaucag      540

cucucuacgc acaccgacgg caucccucau cuggugcugu cccccagcac aguuuucuuu      600

ggggccuucg cucucuga                                                    618


<210>  4656
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__AAA61199

<400>  4656
augacaccac cagaaagacu auuccuacca cgcgucugcg gaacaacauu acaccucuua       60

cuacuaggac uacuauuagu auuacuacca ggagcacaag gccuaccagg aguaggacua      120

acaccaucag cugcacaaac agcacgccaa cacccaaaaa ugcacuuagc acacucaacu      180

uuaaaaccag cagcacaucu aauaggagac ccaucaaaac aaaacucacu auuauggaga      240

gcaaacacag acagagcauu ccuacaagac ggauucuccu uaucaaacaa cucacuccua      300

guaccaacau caggaauaua cuucguauac ucacaaguag uauuuucagg aaaagcauac      360

ucacccaaag caacaucauc accccuauac cuagcacacg aaguacaacu auucucaucu      420

caauacccau uccacguacc cuuacuaucu ucacaaaaaa ugguauaccc aggccuacaa      480

gaaccauggu uacacucaau guaccacgga gcagcauucc aacuaacaca aggcgaccaa      540

uuaucaacac acacagacgg aauaccacac cuaguacuau caccaucaac agucuucuuc      600

ggagcauucg cacuauaa                                                    618


<210>  4657
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__P09960

<400>  4657

Met Pro Glu Ile Val Asp Thr Cys Ser Leu Ala Ser Pro Ala Ser Val 
1               5                   10                  15      


Cys Arg Thr Lys His Leu His Leu Arg Cys Ser Val Asp Phe Thr Arg 
            20                  25                  30          


Arg Thr Leu Thr Gly Thr Ala Ala Leu Thr Val Gln Ser Gln Glu Asp 
        35                  40                  45              


Asn Leu Arg Ser Leu Val Leu Asp Thr Lys Asp Leu Thr Ile Glu Lys 
    50                  55                  60                  


Val Val Ile Asn Gly Gln Glu Val Lys Tyr Ala Leu Gly Glu Arg Gln 
65                  70                  75                  80  


Ser Tyr Lys Gly Ser Pro Met Glu Ile Ser Leu Pro Ile Ala Leu Ser 
                85                  90                  95      


Lys Asn Gln Glu Ile Val Ile Glu Ile Ser Phe Glu Thr Ser Pro Lys 
            100                 105                 110         


Ser Ser Ala Leu Gln Trp Leu Thr Pro Glu Gln Thr Ser Gly Lys Glu 
        115                 120                 125             


His Pro Tyr Leu Phe Ser Gln Cys Gln Ala Ile His Cys Arg Ala Ile 
    130                 135                 140                 


Leu Pro Cys Gln Asp Thr Pro Ser Val Lys Leu Thr Tyr Thr Ala Glu 
145                 150                 155                 160 


Val Ser Val Pro Lys Glu Leu Val Ala Leu Met Ser Ala Ile Arg Asp 
                165                 170                 175     


Gly Glu Thr Pro Asp Pro Glu Asp Pro Ser Arg Lys Ile Tyr Lys Phe 
            180                 185                 190         


Ile Gln Lys Val Pro Ile Pro Cys Tyr Leu Ile Ala Leu Val Val Gly 
        195                 200                 205             


Ala Leu Glu Ser Arg Gln Ile Gly Pro Arg Thr Leu Val Trp Ser Glu 
    210                 215                 220                 


Lys Glu Gln Val Glu Lys Ser Ala Tyr Glu Phe Ser Glu Thr Glu Ser 
225                 230                 235                 240 


Met Leu Lys Ile Ala Glu Asp Leu Gly Gly Pro Tyr Val Trp Gly Gln 
                245                 250                 255     


Tyr Asp Leu Leu Val Leu Pro Pro Ser Phe Pro Tyr Gly Gly Met Glu 
            260                 265                 270         


Asn Pro Cys Leu Thr Phe Val Thr Pro Thr Leu Leu Ala Gly Asp Lys 
        275                 280                 285             


Ser Leu Ser Asn Val Ile Ala His Glu Ile Ser His Ser Trp Thr Gly 
    290                 295                 300                 


Asn Leu Val Thr Asn Lys Thr Trp Asp His Phe Trp Leu Asn Glu Gly 
305                 310                 315                 320 


His Thr Val Tyr Leu Glu Arg His Ile Cys Gly Arg Leu Phe Gly Glu 
                325                 330                 335     


Lys Phe Arg His Phe Asn Ala Leu Gly Gly Trp Gly Glu Leu Gln Asn 
            340                 345                 350         


Ser Val Lys Thr Phe Gly Glu Thr His Pro Phe Thr Lys Leu Val Val 
        355                 360                 365             


Asp Leu Thr Asp Ile Asp Pro Asp Val Ala Tyr Ser Ser Val Pro Tyr 
    370                 375                 380                 


Glu Lys Gly Phe Ala Leu Leu Phe Tyr Leu Glu Gln Leu Leu Gly Gly 
385                 390                 395                 400 


Pro Glu Ile Phe Leu Gly Phe Leu Lys Ala Tyr Val Glu Lys Phe Ser 
                405                 410                 415     


Tyr Lys Ser Ile Thr Thr Asp Asp Trp Lys Asp Phe Leu Tyr Ser Tyr 
            420                 425                 430         


Phe Lys Asp Lys Val Asp Val Leu Asn Gln Val Asp Trp Asn Ala Trp 
        435                 440                 445             


Leu Tyr Ser Pro Gly Leu Pro Pro Ile Lys Pro Asn Tyr Asp Met Thr 
    450                 455                 460                 


Leu Thr Asn Ala Cys Ile Ala Leu Ser Gln Arg Trp Ile Thr Ala Lys 
465                 470                 475                 480 


Glu Asp Asp Leu Asn Ser Phe Asn Ala Thr Asp Leu Lys Asp Leu Ser 
                485                 490                 495     


Ser His Gln Leu Asn Glu Phe Leu Ala Gln Thr Leu Gln Arg Ala Pro 
            500                 505                 510         


Leu Pro Leu Gly His Ile Lys Arg Met Gln Glu Val Tyr Asn Phe Asn 
        515                 520                 525             


Ala Ile Asn Asn Ser Glu Ile Arg Phe Arg Trp Leu Arg Leu Cys Ile 
    530                 535                 540                 


Gln Ser Lys Trp Glu Asp Ala Ile Pro Leu Ala Leu Lys Met Ala Thr 
545                 550                 555                 560 


Glu Gln Gly Arg Met Lys Phe Thr Arg Pro Leu Phe Lys Asp Leu Ala 
                565                 570                 575     


Ala Phe Asp Lys Ser His Asp Gln Ala Val Arg Thr Tyr Gln Glu His 
            580                 585                 590         


Lys Ala Ser Met His Pro Val Thr Ala Met Leu Val Gly Lys Asp Leu 
        595                 600                 605             


Lys Val Asp 
    610     


<210>  4658
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__AAA36176

<400>  4658
augcccgaga uaguggauac cuguucguug gccucuccgg cuuccgucug ccggaccaag       60

caccugcacc ugcgcugcag cgucgacuuu acucgccgga cgcugaccgg gacugcugcu      120

cucacggucc agucucagga ggacaaucug cgcagccugg uuuuggauac aaaggaccuu      180

acaauagaaa aaguagugau caauggacaa gaagucaaau augcucuugg agaaagacaa      240

aguuacaagg gaucgccaau ggaaaucucu cuuccuaucg cuuugagcaa aaaucaagaa      300

auuguuauag aaauuucuuu ugagaccucu ccaaaaucuu cugcucucca guggcucacu      360

ccugaacaga cuucugggaa ggaacaccca uaucucuuua gucagugcca ggccauccac      420

ugcagagcaa uccuuccuug ucaggacacu ccuucuguga aauuaaccua uacugcagag      480

gugucugucc cuaaagaacu gguggcacuu augagugcua uucgugaugg agaaacaccu      540

gacccagaag acccaagcag gaaaauauac aaauucaucc aaaaaguucc aauacccugc      600

uaccugauug cuuuaguugu uggagcuuua gaaagcaggc aaauuggccc aagaacuuug      660

guguggucug agaaagagca gguggaaaag ucugcuuaug aguuuucuga gacugaaucu      720

augcuuaaaa uagcagaaga ucugggagga ccguauguau ggggacagua ugaccuauug      780

guccugccac cauccuuccc uuaugguggc auggagaauc cuugccuuac uuuuguaacu      840

ccuacucuac uggcaggcga caagucacuc uccaauguca uugcacauga aauaucucau      900

agcuggacag ggaaucuagu gaccaacaaa acuugggauc acuuuugguu aaaugaggga      960

cauacugugu acuuggaacg ccacauuugc ggacgauugu uuggugaaaa guucagacau     1020

uuuaaugcuc ugggaggaug gggagaacua cagaauucgg uaaagacauu uggggagaca     1080

cauccuuuca ccaaacuugu gguugaucug acagauauag acccugaugu agcuuauucu     1140

ucaguucccu augagaaggg cuuugcuuua cuuuuuuacc uugaacaacu gcuuggagga     1200

ccagagauuu uccuaggauu cuuaaaagcu uauguugaga aguuuuccua uaagagcaua     1260

acuacugaug acuggaagga uuuccuguau uccuauuuua aagauaaggu ugauguucuc     1320

aaucaaguug auuggaaugc cuggcucuac ucuccuggac ugccucccau aaagcccaau     1380

uaugauauga cucugacaaa ugcuuguauu gccuuaaguc aaagauggau uacugccaaa     1440

gaagaugauu uaaauucauu caaugccaca gaccugaagg aucucucuuc ucaucaauug     1500

aaugaguuuu uagcacagac gcuccagagg gcaccucuuc cauuggggca cauaaagcga     1560

augcaagagg uguacaacuu caaugccauu aacaauucug aaauacgauu cagauggcug     1620

cggcucugca uucaauccaa gugggaggac gcaauuccuu uggcgcuaaa gauggcaacu     1680

gaacaaggaa gaaugaaguu uacccggccc uuauucaagg aucuugcugc cuuugacaaa     1740

ucccaugauc aagcuguccg aaccuaccaa gagcacaaag caagcaugca ucccgugacu     1800

gcaaugcugg uggggaaaga cuuaaaagug gauuaa                               1836


<210>  4659
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4659
augcccgaga ucguggacac gugcagccug gccuccccgg ccagcgucug ccgcaccaag       60

caccuccacc uccggugcuc cguggacuuc acccgccgga cccugaccgg caccgcggcc      120

cugacggugc agagccagga ggacaaccug cgcucccugg uccucgacac caaggaccug      180

accaucgaga agguggugau caacgggcag gaggucaagu acgcccuggg cgagcggcag      240

agcuacaagg ggucccccau ggagaucagc cuccccaucg cccuguccaa gaaccaggag      300

aucgugaucg agaucagcuu cgagaccucc cccaagagcu ccgcccugca guggcucacg      360

ccggagcaga ccagcggcaa ggagcacccc uaccuguucu cccagugcca ggcgauccac      420

ugccgcgcca uccugcccug ccaggacacc cccagcguga agcucaccua cacggccgag      480

gucuccgugc cgaaggagcu gguggcccug augagcgcga uccgggacgg ggagaccccc      540

gaccccgagg accccucccg caagaucuac aaguucaucc agaagguccc gauccccugc      600

uaccucaucg cccugguggu gggcgcccug gagagccggc agaucggccc ccgcacccuc      660

gucuggagcg agaaggagca ggucgagaag uccgccuacg aguucagcga gaccgagucc      720

augcugaaga ucgccgagga ccucgggggc cccuacgugu gggggcagua cgaccugcug      780

gugcugccgc ccagcuuccc cuacggcggg auggagaacc ccugccucac guucgugacc      840

ccgacccugc uggcgggcga caagucccuc agcaacguga ucgcccacga gaucucccac      900

agcuggaccg gcaaccuggu cacgaacaag accugggacc acuucuggcu gaacgagggg      960

cacaccgugu accucgagcg gcacaucugc ggccgccugu ucggggagaa guuccggcac     1020

uucaacgccc ugggcggcug gggcgagcuc cagaacuccg ugaagaccuu cggggagacg     1080

caccccuuca ccaagcuggu cguggaccug accgacaucg accccgacgu cgccuacagc     1140

uccgugcccu acgagaaggg guucgcccuc cuguucuacc uggagcagcu ccugggcggg     1200

ccggagaucu uccugggcuu ccucaaggcg uacguggaga aguucagcua caaguccauc     1260

accacggacg acuggaagga cuuccuguac agcuacuuca aggacaaggu cgacgugcug     1320

aaccaggugg acuggaacgc cuggcucuac ucccccggcc ugccgcccau caagcccaac     1380

uacgacauga cccugaccaa cgccugcauc gcccugagcc agcgcuggau caccgccaag     1440

gaggacgacc ucaacuccuu caacgcgacg gaccugaagg accugagcuc ccaccagcuc     1500

aacgaguucc uggcccagac ccugcagcgg gcgccccucc cccuggggca caucaagcgc     1560

augcaggagg ucuacaacuu caacgccauc aacaacagcg agauccgguu ccgcuggcug     1620

cggcucugca uccagagcaa gugggaggac gccaucccgc uggcccugaa gauggccacc     1680

gagcagggcc gcaugaaguu cacccggccc cucuucaagg accuggccgc cuucgacaag     1740

ucccacgacc aggcggugcg cacguaccag gagcacaagg ccagcaugca ccccgugacc     1800

gccaugcugg ucgggaagga ccucaaggug gacuga                               1836


<210>  4660
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4660
augcccgaga ucgucgacac cugcucccuc gccucccccg ccuccgucug ccgcaccaag       60

caccuccacc uccgcugcuc cgucgacuuc acccgccgca cccucaccgg caccgccgcc      120

cucaccgucc agucccagga ggacaaccuc cgcucccucg uccucgacac caaggaccuc      180

accaucgaga aggucgucau caacggccag gaggucaagu acgcccucgg cgagcgccag      240

uccuacaagg gcucccccau ggagaucucc cuccccaucg cccucuccaa gaaccaggag      300

aucgucaucg agaucuccuu cgagaccucc cccaaguccu ccgcccucca guggcucacc      360

cccgagcaga ccuccggcaa ggagcacccc uaccucuucu cccagugcca ggccauccac      420

ugccgcgcca uccuccccug ccaggacacc cccuccguca agcucaccua caccgccgag      480

gucuccgucc ccaaggagcu cgucgcccuc auguccgcca uccgcgacgg cgagaccccc      540

gaccccgagg accccucccg caagaucuac aaguucaucc agaagguccc cauccccugc      600

uaccucaucg cccucgucgu cggcgcccuc gagucccgcc agaucggccc ccgcacccuc      660

gucugguccg agaaggagca ggucgagaag uccgccuacg aguucuccga gaccgagucc      720

augcucaaga ucgccgagga ccucggcggc cccuacgucu ggggccagua cgaccuccuc      780

guccuccccc ccuccuuccc cuacggcggc auggagaacc ccugccucac cuucgucacc      840

cccacccucc ucgccggcga caagucccuc uccaacguca ucgcccacga gaucucccac      900

uccuggaccg gcaaccucgu caccaacaag accugggacc acuucuggcu caacgagggc      960

cacaccgucu accucgagcg ccacaucugc ggccgccucu ucggcgagaa guuccgccac     1020

uucaacgccc ucggcggcug gggcgagcuc cagaacuccg ucaagaccuu cggcgagacc     1080

caccccuuca ccaagcucgu cgucgaccuc accgacaucg accccgacgu cgccuacucc     1140

uccguccccu acgagaaggg cuucgcccuc cucuucuacc ucgagcagcu ccucggcggc     1200

cccgagaucu uccucggcuu ccucaaggcc uacgucgaga aguucuccua caaguccauc     1260

accaccgacg acuggaagga cuuccucuac uccuacuuca aggacaaggu cgacguccuc     1320

aaccaggucg acuggaacgc cuggcucuac ucccccggcc ucccccccau caagcccaac     1380

uacgacauga cccucaccaa cgccugcauc gcccucuccc agcgcuggau caccgccaag     1440

gaggacgacc ucaacuccuu caacgccacc gaccucaagg accucuccuc ccaccagcuc     1500

aacgaguucc ucgcccagac ccuccagcgc gccccccucc cccucggcca caucaagcgc     1560

augcaggagg ucuacaacuu caacgccauc aacaacuccg agauccgcuu ccgcuggcuc     1620

cgccucugca uccaguccaa gugggaggac gccauccccc ucgcccucaa gauggccacc     1680

gagcagggcc gcaugaaguu cacccgcccc cucuucaagg accucgccgc cuucgacaag     1740

ucccacgacc aggccguccg caccuaccag gagcacaagg ccuccaugca ccccgucacc     1800

gccaugcucg ucggcaagga ccucaagguc gacuga                               1836


<210>  4661
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4661
augcccgaga ucguggauac cugcagccug gccuccccug cuucugucug uagaacaaag       60

caccuccauc uuaggugcuc aguugacuuc acucggcgca cgcugaccgg cacagcagcc      120

uugacugugc agagucaaga agacaacuua cgaagccugg uacuagauac caaagaccuc      180

acaauugaga agguggucau aaaugggcag gaagugaaau acgcgcuggg agagcgucag      240

uccuauaagg guucuccaau ggaaaucucg cuuccgauug cucugucaaa gaaccaggag      300

aucguuauug agaucagcuu ugaaaccagu cccaaguccu cugccuugca auggcucacu      360

ccugagcaga caagcggcaa ggaacaccca uaccuguucu cccaguguca ggcaauacau      420

ugcagagcca uccugcccug ucaagauacc ccuucaguga aacucacgua uacugcugag      480

gucagugugc caaaggaguu aguagcacug augagcgcca uuagggacgg ggaaaccccc      540

gauccugagg acccaucucg gaaaaucuac aaguuuauuc agaaaguucc gauccccugc      600

uaucuuauag cuuugguggu cggagcccug gaaucccgcc agauuggccc uagaacacuu      660

guguggucag agaaggaaca gguggagaaa agcgcguacg aguucaguga aacugagucu      720

augcucaaaa ucgcagaaga ucuggguggg ccauaugucu ggggacaaua cgaccuucug      780

guuuugcccc cuuccuuucc auacggcggc auggagaauc ccugucucac cuucgugaca      840

ccgacccugu uagccgggga uaagagccug ucgaacguaa uugcucacga aaucucucau      900

uccuggacgg gaaaucucgu gacuaacaaa acaugggacc acuuuuggcu uaaugagggu      960

cacaccgucu aucuggagag gcauaucugc ggccgguugu ucggggaaaa guuucgccac     1020

uucaacgccc uaggaggcug gggugagcug caaaauucag ugaaaacuuu uggggaaaca     1080

cauccuuuca ccaagcucgu uguggaucug acggacauug accccgaugu cgcauacagu     1140

agcgugccau augagaaagg auuugcucua cuguucuacu uggaacagcu ccugggcggc     1200

ccugagauau ucuuaggguu ucugaaggcc uauguagaga aguucuccua caaaucuauc     1260

accacagacg auuggaagga cuuucuauau agcuacuuca aagauaaggu ugacgugcuc     1320

aaccaggucg auuggaaugc guggcuguac ucacccggac uuccacccau uaaaccuaac     1380

uaugacauga cuuugaccaa ugccuguauc gcacugaguc agcgauggau aacagcuaag     1440

gaagaugacc ucaacuccuu uaaugccacu gaucugaagg accuuagcuc ucaccagcug     1500

aacgaguucu uggcucagac ccuccaaaga gccccacugc cguuagguca cauuaaaagg     1560

augcaggaag uguacaacuu uaaugcaauc aacaauucag agauccgguu ccguuggcug     1620

cgccuaugca uucagaguaa gugggaggac gccauccccc ucgcucugaa aauggcgaca     1680

gaacagggca gaaugaaguu uaccaggccu cuuuucaaag auuuggcagc cuuugacaag     1740

agccaugauc aagcuguccg gacuuaucag gagcacaagg ccuccaugca uccagugacg     1800

gcaaugcugg uugggaaaga ccucaaggug gauuga                               1836


<210>  4662
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4662
augcccgaga ucguggacac cugcagccug gccagccccg ccagcgugug cagaaccaag       60

caccugcacc ugagaugcag cguggacuuc accagaagaa cccugaccgg caccgccgcc      120

cugaccgugc agagccagga ggacaaccug agaagccugg ugcuggacac caaggaccug      180

accaucgaga agguggugau caacggccag gaggugaagu acgcccuggg cgagagacag      240

agcuacaagg gcagccccau ggagaucagc cugcccaucg cccugagcaa gaaccaggag      300

aucgugaucg agaucagcuu cgagaccagc cccaagagca gcgcccugca guggcugacc      360

cccgagcaga ccagcggcaa ggagcacccc uaccuguuca gccagugcca ggccauccac      420

ugcagagcca uccugcccug ccaggacacc cccagcguga agcugaccua caccgccgag      480

gugagcgugc ccaaggagcu gguggcccug augagcgcca ucagagacgg cgagaccccc      540

gaccccgagg accccagcag aaagaucuac aaguucaucc agaaggugcc cauccccugc      600

uaccugaucg cccugguggu gggcgcccug gagagcagac agaucggccc cagaacccug      660

guguggagcg agaaggagca gguggagaag agcgccuacg aguucagcga gaccgagagc      720

augcugaaga ucgccgagga ccugggcggc cccuacgugu ggggccagua cgaccugcug      780

gugcugcccc ccagcuuccc cuacggcggc auggagaacc ccugccugac cuucgugacc      840

cccacccugc uggccggcga caagagccug agcaacguga ucgcccacga gaucagccac      900

agcuggaccg gcaaccuggu gaccaacaag accugggacc acuucuggcu gaacgagggc      960

cacaccgugu accuggagag acacaucugc ggcagacugu ucggcgagaa guucagacac     1020

uucaacgccc ugggcggcug gggcgagcug cagaacagcg ugaagaccuu cggcgagacc     1080

caccccuuca ccaagcuggu gguggaccug accgacaucg accccgacgu ggccuacagc     1140

agcgugcccu acgagaaggg cuucgcccug cuguucuacc uggagcagcu gcugggcggc     1200

cccgagaucu uccugggcuu ccugaaggcc uacguggaga aguucagcua caagagcauc     1260

accaccgacg acuggaagga cuuccuguac agcuacuuca aggacaaggu ggacgugcug     1320

aaccaggugg acuggaacgc cuggcuguac agccccggcc ugccccccau caagcccaac     1380

uacgacauga cccugaccaa cgccugcauc gcccugagcc agagauggau caccgccaag     1440

gaggacgacc ugaacagcuu caacgccacc gaccugaagg accugagcag ccaccagcug     1500

aacgaguucc uggcccagac ccugcagaga gccccccugc cccugggcca caucaagaga     1560

augcaggagg uguacaacuu caacgccauc aacaacagcg agaucagauu cagauggcug     1620

agacugugca uccagagcaa gugggaggac gccauccccc uggcccugaa gauggccacc     1680

gagcagggca gaaugaaguu caccagaccc cuguucaagg accuggccgc cuucgacaag     1740

agccacgacc aggccgugag aaccuaccag gagcacaagg ccagcaugca ccccgugacc     1800

gccaugcugg ugggcaagga ccugaaggug gacuga                               1836


<210>  4663
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4663
augcccgaga ucguggauac cugcagccug gccuccccug cuucugucug uagaacaaag       60

caccuccauc ugcggugcag cguugacuuc acgcgcagaa cccuuacagg caccgccgcg      120

cugacagugc agucccaaga agacaaccuc cggucucugg ugcuugauac caaagaccug      180

acaauugaga aggucgugau caaugggcag gaaguuaaau acgcucucgg agagcgccag      240

agcuauaagg gcuccccgau ggaaauuucu cugcccaucg cccugagcaa aaaccaggag      300

auugugaucg agaucuccuu ugaaaccagc ccuaagucuu ccgcccucca auggcugacg      360

cccgagcaga ccagcgggaa ggaacacccu uaccuuuucu cucaguguca ggcuauucau      420

ugcagagcca uccugcccug ucaagauaca ccuuccguca aacucaccua uacagcugag      480

gugagcguuc cgaaggagcu gguggcccuu augucugcga uucgggacgg agaaaccccc      540

gauccugagg accccucccg caaaaucuac aaguuuauuc agaaaguccc uauccccugc      600

uaucugauug cccucguggu gggcgcucug gaaagcagac agaucgggcc gcggacgcug      660

gucugguccg agaaggaaca gguugagaag ucugccuacg aguucagcga aacagagucc      720

augcucaaaa ucgcugaaga ucugggaggc ccuuaugugu ggggccaaua cgaccuucug      780

gugcugcccc cuagcuuucc cuacggggga auggagaauc ccugucucac cuucgucaca      840

ccuacccuuc uggccggcga uaagucucuc uccaacguga uugcgcacga aaucagccau      900

ucuuggaccg ggaaucuggu uacaaacaaa acgugggacc acuuuuggcu gaaugaggga      960

cacaccgugu aucucgagcg ccauauuugc ggcagacugu ucggggaaaa guuucggcac     1020

uucaacgccc uuggaggcug gggcgagcug cagaauagcg ucaaaacauu uggggaaacc     1080

cauccguuca caaagcucgu gguugaucug accgacaucg accccgaugu ggcuuacucc     1140

ucugucccuu augagaaagg auuugcccuu cuguucuacc ucgaacagcu gcugggcggg     1200

cccgagauuu uccucggauu ucugaaggcu uauguggaga aguucagcua caaauccauc     1260

acgacagacg auuggaagga cuuucuuuau agcuacuuca aagauaaggu cgacgugcug     1320

aaccaaguug auuggaaugc cuggcucuac ucuccuggcc ugcccccgau caaaccuaac     1380

uaugacauga cccugaccaa ugccuguauu gcucuuuccc agcgcuggau cacagcgaag     1440

gaagaugacc ucaacagcuu uaaugccacc gaucugaagg accugucuuc ccaccagcuc     1500

aacgaguucc uggcucagac acuucaaaga gcuccccugc cucucgggca cauuaaacgg     1560

augcaggaag uguacaacuu uaaugccauc aacaauagcg agauucgcuu cagauggcug     1620

cggcugugca uccaguccaa gugggaggac gccauccccc uugcccucaa aauggcgacg     1680

gaacagggaa gaaugaaguu uacccgcccu cuguucaaag aucuggcugc cuuugacaag     1740

ucucaugauc aagccguccg gacauaucag gagcacaagg cuagcaugca ucccgugacc     1800

gccaugcucg uuggcaaaga ccugaaggug gauuga                               1836


<210>  4664
<211>  1836
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__AAA36176

<400>  4664
augccagaaa uaguagauac uuguucacua gcaagcccag caucugucug uagaacuaaa       60

caccuacacc ucaggugcuc uguagauuuc acacgacgaa cauuaacagg cacagcugca      120

cuuacaguac aaucacaaga agauaacuua agaagcuuag uacuagacac aaaagacuua      180

acuauagaga aaguuguaau aaauggucaa gaaguaaaau augcacuugg ugaacgucaa      240

ucauacaaag gaucuccuau ggaaauauca uuacccaucg cuuuaagcaa aaaccaagaa      300

auugucauug aaaucuccuu cgaaacaagc ccaaaaucau cagcacuaca auggcuaacc      360

ccugagcaaa cuucaggcaa agaacacccc uacuuauucu cacaauguca agcaauacac      420

uguagggcaa uauuaccaug ucaagacaca ccaucaguua aacuaacuua uaccgcagaa      480

guaucaguac ccaaagaauu aguagccuua augucagcaa uaagagaugg agaaacuccc      540

gacccagaag aucccagccg uaaaauuuau aaauucauuc agaaaguacc uauaccuugu      600

uaccuaauug cccuagucgu cggagcccua gaaagcagac aaauaggacc aagaacacua      660

guauggagug agaaagaaca aguagaaaaa uccgccuaug aauuuucaga aacagaauca      720

auguuaaaaa uagcagagga ucucggagga ccauacguuu ggggucaaua cgaucuccua      780

guauuaccuc caucauuccc cuacggagga auggaaaauc ccugucuaac auucguaacc      840

ccaacauuac uagcaggaga uaaaucgcua uccaacguaa uugcacauga aauaucacau      900

ucauggacag guaaccuagu aacaaacaaa acaugggauc acuucugguu aaaugaagga      960

cauacaguau accuagaacg ucauauaugc ggcagacuuu ucggagaaaa guuucgacac     1020

uuuaacgcac uagguggcug gggggaacuc caaaacucag uuaaaacauu uggagaaaca     1080

caucccuuca caaaacuagu aguagaucua accgauauug acccagacgu ugcuuauuca     1140

ucaguuccau acgaaaaagg auucgcacua cuauuuuacc uagaacaacu uuuaggcgga     1200

ccugaaauuu ucuuaggcuu ucuaaaagca uacguagaaa aauuuaguua uaaaucaauc     1260

acaacagaug acuggaaaga uuucuuauau ucguacuuca aggauaaagu agacguacua     1320

aaucaaguag acuggaacgc auggcuauac ucuccaggac ucccuccaau uaaacccaac     1380

uacgauauga cauuaacaaa cgcauguaua gcacuaucac aaagauggau uacagcuaaa     1440

gaagacgacc uuaauucauu caacgcaaca gauuuaaaag accuaucauc ucaucaacuc     1500

aacgaauucc uagcacaaac cuuacaaaga gcaccacuac cacuaggaca cauaaaaaga     1560

augcaagaag ucuauaacuu uaacgcaaua aauaacucag aaauuagauu uagauggcuc     1620

agacucugua uacaaucaaa augggaggau gcaauaccau uagcacuaaa aauggcaaca     1680

gaacaaggua gaaugaaauu uacaagaccu cuuuuuaaag accucgccgc auucgacaaa     1740

ucacacgacc aagcaguaag aacuuaucaa gaacacaagg ccucaaugca uccaguaaca     1800

gcaaugcuag uuggaaaaga uuuaaaaguc gauuaa                               1836


<210>  4665
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__Q5ST95

<400>  4665

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Asn Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  4666
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__BAE78638

<400>  4666
augacaccac cugaacgucu cuuccuccca agggugugug gcaccacccu acaccuccuc       60

cuucuggggc ugcugcuggu ucugcugccu ggggcccagg ggcucccugg uguuggccuc      120

acaccuucag cugcccagac ugcccgucag caccccaaga ugcaucuugc ccacagcaac      180

cucaaaccug cugcucaccu cauuggagac cccagcaagc agaacucacu gcucuggaga      240

gcaaacacgg accgugccuu ccuccaggau gguuucuccu ugagcaacaa uucucuccug      300

guccccacca guggcaucua cuucgucuac ucccaggugg ucuucucugg gaaagccuac      360

ucucccaagg ccaccuccuc cccacucuac cuggcccaug agguccagcu cuucuccucc      420

caguaccccu uccaugugcc ucuccucagc ucccagaaga ugguguaucc agggcugcag      480

gaacccuggc ugcacucgau guaccacggg gcugcguucc agcucaccca gggagaccag      540

cuauccaccc acacagaugg caucccccac cuaguccuca gcccuaguac ugucuucuuu      600

ggagccuucg cucuguag                                                    618


<210>  4667
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4667
augacgcccc cggagcgccu guuccucccc cgggugugcg gcaccacccu gcaccuccuc       60

cugcuggggc uccugcuggu ccuccugccc ggcgcccagg ggcugcccgg cguggggcuc      120

accccgagcg ccgcgcagac cgcccgccag caccccaaga ugcaccuggc ccacuccaac      180

cugaagcccg ccgcccaccu caucggcgac cccagcaagc agaacucccu gcuguggcgg      240

gcgaacaccg accgcgccuu ccuccaggac ggcuucagcc uguccaacaa cagccugcuc      300

gugccgacgu ccgggaucua cuucgucuac agccaggugg uguucuccgg caaggccuac      360

agccccaagg ccaccuccag cccccuguac cuggcgcacg agguccagcu guucuccagc      420

caguaccccu uccacgugcc gcugcugucc agccagaaga ugguguaccc cgggcuccag      480

gagcccuggc ugcacuccau guaccacggc gccgccuucc agcugaccca gggggaccag      540

cucagcaccc acacggacgg caucccccac cugguccugu ccccgagcac cguguucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4668
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4668
augacccccc ccgagcgccu cuuccucccc cgcgucugcg gcaccacccu ccaccuccuc       60

cuccucggcc uccuccucgu ccuccucccc ggcgcccagg gccuccccgg cgucggccuc      120

acccccuccg ccgcccagac cgcccgccag caccccaaga ugcaccucgc ccacuccaac      180

cucaagcccg ccgcccaccu caucggcgac cccuccaagc agaacucccu ccucuggcgc      240

gccaacaccg accgcgccuu ccuccaggac ggcuucuccc ucuccaacaa cucccuccuc      300

guccccaccu ccggcaucua cuucgucuac ucccaggucg ucuucuccgg caaggccuac      360

ucccccaagg ccaccuccuc cccccucuac cucgcccacg agguccagcu cuucuccucc      420

caguaccccu uccacguccc ccuccucucc ucccagaaga uggucuaccc cggccuccag      480

gagcccuggc uccacuccau guaccacggc gccgccuucc agcucaccca gggcgaccag      540

cucuccaccc acaccgacgg caucccccac cucguccucu cccccuccac cgucuucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4669
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4669
augacacccc cugagagacu guuccuccca agggugugcg gcaccacucu ucaccuguug       60

uuacuggggc uacuccuggu ccuucugccg ggagcccagg guuugcccgg cguugggcuc      120

acgccuagcg cugcacaaac cgcccggcag cauccaaaga ugcaccuggc gcauuccaac      180

cugaaacccg cugcccaccu caucggagac ccuucuaagc agaacucauu acuguggcgc      240

gcaaauacag aucgagccuu ucuucaggac ggcuucaguu ugagcaauaa cucccugcua      300

gugccaacuu cugguauuua cuuuguauau ucgcaagugg ucuucucagg gaaggcuuac      360

agccccaaag caaccaguuc cccucucuau cuggcccaug aagugcagcu guuuucuagc      420

caguacccau uccacguucc gcuuuugucc ucacagaaaa ugguguaucc cggacuccaa      480

gagccuuggc ugcacaguau guaccauggc gcugccuuuc aguuaacaca gggcgaucag      540

cugagcaccc acacugacgg gauaccacau cucguccuuu cucccuccac aguguucuuu      600

ggagcguucg cacuguga                                                    618


<210>  4670
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4670
augacccccc ccgagagacu guuccugccc agagugugcg gcaccacccu gcaccugcug       60

cugcugggcc ugcugcuggu gcugcugccc ggcgcccagg gccugcccgg cgugggccug      120

acccccagcg ccgcccagac cgccagacag caccccaaga ugcaccuggc ccacagcaac      180

cugaagcccg ccgcccaccu gaucggcgac cccagcaagc agaacagccu gcuguggaga      240

gccaacaccg acagagccuu ccugcaggac ggcuucagcc ugagcaacaa cagccugcug      300

gugcccacca gcggcaucua cuucguguac agccaggugg uguucagcgg caaggccuac      360

agccccaagg ccaccagcag cccccuguac cuggcccacg aggugcagcu guucagcagc      420

caguaccccu uccacgugcc ccugcugagc agccagaaga ugguguaccc cggccugcag      480

gagcccuggc ugcacagcau guaccacggc gccgccuucc agcugaccca gggcgaccag      540

cugagcaccc acaccgacgg caucccccac cuggugcuga gccccagcac cguguucuuc      600

ggcgccuucg cccuguga                                                    618


<210>  4671
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4671
augacacccc cugagagacu guuccucccg cgggugugcg gcaccacgcu gcaccuucug       60

cuccuggggc uucugcucgu ccugcugccc ggagcccagg gccucccugg gguuggacug      120

acccccagcg cugcccaaac agcgcgccag cauccuaaga ugcaccuugc ucauuccaac      180

cugaaacccg ccgcccaccu caucggcgac ccuucuaagc agaauagccu gcuuuggaga      240

gcuaacaccg aucgggccuu ucugcaggac ggguucuccc ucucuaauaa cagccugcug      300

gugccgacau ccggaauuua cuuuguguau ucucaagucg uguucagcgg caaggcuuac      360

ucccccaaag ccaccagcuc uccucucuau cuggcgcaug aaguucagcu guuuuccagc      420

caguaccccu uccacgugcc ucuucucucu ucccagaaaa uggucuaucc cggccugcaa      480

gagccguggc uucacagcau guaccauggg gccgcuuuuc agcugacaca gggagaucag      540

cucucuaccc acacggacgg caucccucau cuggugcugu cccccagcac cguuuucuuu      600

ggggccuucg cucucuga                                                    618


<210>  4672
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__BAE78638

<400>  4672
augacaccac cagaaagacu auuccuacca agaguaugcg gaacaacauu acaccuacua       60

cuacuaggau uacuacuagu auuauuaccc ggagcacaag gccuaccagg aguuggacua      120

acaccaucag cagcacaaac agcaagacaa cacccaaaaa ugcaccuagc acacucaaau      180

cuaaaacccg cagcacaccu aaucggagac cccuccaaac aaaacucacu ucuauggaga      240

gcaaauacag auagagcauu ccuacaagac ggcuucucau uaucaaacaa cucacuacua      300

guaccaacau cuggaauaua cuucguauau ucccaaguag uauucucagg aaaagcauac      360

ucaccaaaag caacaucauc cccacuauac uuagcacacg aaguacaauu auuuucaucc      420

caauacccau uucacguccc acuacuauca ucccaaaaaa ugguauaucc aggacuacaa      480

gaaccauggc uacacucaau guaccacggc gcagcauuuc aauuaacaca aggcgaccaa      540

cuaucaacac acacagacgg cauaccacac cuaguacuau caccaucaac aguauucuuc      600

ggcgcauucg cacuauaa                                                    618


<210>  4673
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__Q5STV3

<400>  4673

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  4674
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__BAC54943

<400>  4674
augacaccac cugaacgucu cuuccuccca agggugugug gcaccacccu acaccuccuc       60

cuucuggggc ugcugcuggu ucugcugccu ggggcccagg ggcucccugg uguuggccuc      120

acaccuucag cugcccagac ugcccgucag caccccaaga ugcaucuugc ccacagcacc      180

cucaaaccug cugcucaccu cauuggagac cccagcaagc agaacucacu gcucuggaga      240

gcaaacacgg accgugccuu ccuccaggau gguuucuccu ugagcaacaa uucucuccug      300

guccccacca guggcaucua cuucgucuac ucccaggugg ucuucucugg gaaagccuac      360

ucucccaagg ccaccuccuc cccacucuac cuggcccaug agguccagcu cuucuccucc      420

caguaccccu uccaugugcc ucuccucagc ucccagaaga ugguguaucc agggcugcag      480

gaacccuggc ugcacucgau guaccacggg gcugcguucc agcucaccca gggagaccag      540

cuauccaccc acacagaugg caucccccac cuaguccuca gcccuaguac ugucuucuuu      600

ggagccuucg cucuguag                                                    618


<210>  4675
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4675
augacgcccc cggagcgccu guuccucccc cgggugugcg gcaccacccu gcaccuccuc       60

cugcuggggc uccugcuggu ccuccugccc ggcgcccagg ggcugcccgg cguggggcuc      120

accccgagcg ccgcgcagac cgcccgccag caccccaaga ugcaccuggc ccacuccacc      180

cugaagcccg ccgcccaccu caucggcgac cccagcaagc agaacucccu gcuguggcgg      240

gcgaacacgg accgcgccuu ccuccaggac ggcuucagcc uguccaacaa cagccugcuc      300

gugccgaccu ccgggaucua cuucgucuac agccaggugg uguucuccgg caaggccuac      360

agccccaagg ccaccuccag cccccuguac cuggcgcacg agguccagcu guucuccagc      420

caguaccccu uccacgugcc gcugcugucc agccagaaga ugguguaccc cgggcuccag      480

gagcccuggc ugcacuccau guaccacggc gccgccuucc agcugaccca gggggaccag      540

cucagcacgc acaccgacgg caucccccac cugguccugu ccccgagcac cguguucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4676
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4676
augacccccc ccgagcgccu cuuccucccc cgcgucugcg gcaccacccu ccaccuccuc       60

cuccucggcc uccuccucgu ccuccucccc ggcgcccagg gccuccccgg cgucggccuc      120

acccccuccg ccgcccagac cgcccgccag caccccaaga ugcaccucgc ccacuccacc      180

cucaagcccg ccgcccaccu caucggcgac cccuccaagc agaacucccu ccucuggcgc      240

gccaacaccg accgcgccuu ccuccaggac ggcuucuccc ucuccaacaa cucccuccuc      300

guccccaccu ccggcaucua cuucgucuac ucccaggucg ucuucuccgg caaggccuac      360

ucccccaagg ccaccuccuc cccccucuac cucgcccacg agguccagcu cuucuccucc      420

caguaccccu uccacguccc ccuccucucc ucccagaaga uggucuaccc cggccuccag      480

gagcccuggc uccacuccau guaccacggc gccgccuucc agcucaccca gggcgaccag      540

cucuccaccc acaccgacgg caucccccac cucguccucu cccccuccac cgucuucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4677
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4677
augacacccc cugagagacu guuccuccca agggugugcg gcaccacucu ucaccuguug       60

uuacuggggc uacuccuggu ccuucugccg ggagcccagg guuugcccgg cguugggcuc      120

acgccuagcg cugcacaaac cgcccggcag cauccaaaga ugcaccuggc gcauuccaca      180

cugaaacccg cugcccaccu caucggagac ccuucuaagc agaacucauu acuguggcgc      240

gcaaauacug aucgagccuu ucuucaggac ggcuucaguu ugagcaacaa uucccugcua      300

gugccaaccu cugguauuua cuuuguauau ucgcaagugg ucuucucagg gaaggcuuac      360

agccccaaag caacaaguuc cccucucuau cuggcccaug aagugcagcu guuuucuagc      420

caguacccau uccacguucc gcuuuugucc ucacagaaaa ugguguaucc cggacuccaa      480

gagccuuggc ugcacaguau guaccauggc gcugccuuuc aguuaaccca gggcgaucag      540

cugagcacuc acacagacgg gauaccacau cucguccuuu cucccuccac cguguucuuu      600

ggagcguucg cacuguga                                                    618


<210>  4678
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4678
augacccccc ccgagagacu guuccugccc agagugugcg gcaccacccu gcaccugcug       60

cugcugggcc ugcugcuggu gcugcugccc ggcgcccagg gccugcccgg cgugggccug      120

acccccagcg ccgcccagac cgccagacag caccccaaga ugcaccuggc ccacagcacc      180

cugaagcccg ccgcccaccu gaucggcgac cccagcaagc agaacagccu gcuguggaga      240

gccaacaccg acagagccuu ccugcaggac ggcuucagcc ugagcaacaa cagccugcug      300

gugcccacca gcggcaucua cuucguguac agccaggugg uguucagcgg caaggccuac      360

agccccaagg ccaccagcag cccccuguac cuggcccacg aggugcagcu guucagcagc      420

caguaccccu uccacgugcc ccugcugagc agccagaaga ugguguaccc cggccugcag      480

gagcccuggc ugcacagcau guaccacggc gccgccuucc agcugaccca gggcgaccag      540

cugagcaccc acaccgacgg caucccccac cuggugcuga gccccagcac cguguucuuc      600

ggcgccuucg cccuguga                                                    618


<210>  4679
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4679
augacacccc cugagagacu guuccucccg cgggugugcg gcaccacgcu gcaccuucug       60

cuccuggggc uucugcucgu ccugcugccc ggagcccagg gccucccugg gguuggacug      120

acccccagcg cugcccaaac agcgcgccag cauccuaaga ugcaccuugc ucauuccacc      180

cugaaacccg ccgcccaccu caucggcgac ccuucuaagc agaacagccu gcuuuggaga      240

gcuaauacag aucgggccuu ucugcaggac ggguucuccc ucucuaacaa uagccugcug      300

gugccgaccu ccggaauuua cuuuguguau ucucaagucg uguucagcgg caaggcuuac      360

ucccccaaag ccacaagcuc uccucucuau cuggcgcaug aaguucagcu guuuuccagc      420

caguaccccu uccacgugcc ucuucucucu ucccagaaaa uggucuaucc cggccugcaa      480

gagccguggc uucacagcau guaccauggg gccgcuuuuc agcugaccca gggagaucag      540

cucucuacgc acaccgacgg caucccucau cuggugcugu cccccagcac aguuuucuuu      600

ggggccuucg cucucuga                                                    618


<210>  4680
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__BAC54943

<400>  4680
augacaccac cagaacgccu auuuuuacca agaguaugcg gaacaacacu acaucuacua       60

cuacuaggac uacuacuagu auuacuacca ggagcacaag gauuaccagg aguaggacua      120

acaccaucag cagcacaaac agcaagacaa cacccaaaaa ugcaucuagc acacucuaca      180

cuaaaaccag cagcacaccu cauaggagac ccaucaaaac aaaacucacu auuauggaga      240

gcaaacacag acagagcauu ccuacaagac ggauuuucac uaucaaacaa cucacuacua      300

gucccaacau caggaauaua cuucguauac ucacaaguag uauucucagg caaagcauau      360

ucaccaaaag caaccucauc accacuauac cuagcacacg aaguccaacu auucucauca      420

caauacccau uccacguacc auuacuauca ucacaaaaaa ugguauaucc aggacuacaa      480

gaaccauggc uacacucaau guaccacgga gccgcauucc aacuaacaca aggcgaccaa      540

cuaucaacac acacagaugg aauaccacac uuaguauuau cacccucaac cgucuucuuc      600

ggagcauucg cacuauaa                                                    618


<210>  4681
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__Q6FG55

<400>  4681

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Arg Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  4682
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTalpha__Homo_sapiens__CAG47049

<400>  4682
augacaccac cugaacgucu cuuccuccca agggugcgug gcaccacccu acaccuccuc       60

cuucuggggc ugcugcuggu ucugcugccu ggggcccagg ggcucccugg uguuggccuc      120

acaccuucag cugcccagac ugcccgucag caccccaaga ugcaucuugc ccacagcacc      180

cucaaaccug cugcucaccu cauuggagac cccagcaagc agaacucacu gcucuggaga      240

gcaaacacgg accgugccuu ccuccaggau gguuucuccu ugagcaacaa uucucuccug      300

guccccacca guggcaucua cuucgucuac ucccaggugg ucuucucugg gaaagccuac      360

ucucccaagg ccaccuccuc cccacucuac cuggcccaug agguccagcu cuucuccucc      420

caguaccccu uccaugugcc ucuccucagc ucccagaaga ugguguaucc agggcugcag      480

gaacccuggc ugcacucgau guaccacggg gcugcguucc agcucaccca gggagaccag      540

cuauccaccc acacagaugg caucccccac cuaguccuca gcccuaguac ugucuucuuu      600

ggagccuucg cucuguag                                                    618


<210>  4683
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4683
augacgcccc cggagcgccu guuccucccc cgggugcgcg gcaccacccu gcaccuccuc       60

cugcuggggc uccugcuggu ccuccugccc ggcgcccagg ggcugcccgg cguggggcuc      120

accccgagcg ccgcgcagac cgcccggcag caccccaaga ugcaccuggc ccacuccacc      180

cugaagcccg ccgcccaccu caucggcgac cccagcaagc agaacucccu gcuguggcgc      240

gcgaacacgg accgggccuu ccuccaggac ggcuucagcc uguccaacaa cagccugcuc      300

gugccgaccu ccgggaucua cuucgucuac agccaggugg uguucuccgg caaggccuac      360

agccccaagg ccaccuccag cccccuguac cuggcgcacg agguccagcu guucuccagc      420

caguaccccu uccacgugcc gcugcugucc agccagaaga ugguguaccc cgggcuccag      480

gagcccuggc ugcacuccau guaccacggc gccgccuucc agcugaccca gggggaccag      540

cucagcacgc acaccgacgg caucccccac cugguccugu ccccgagcac cguguucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4684
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4684
augacccccc ccgagcgccu cuuccucccc cgcguccgcg gcaccacccu ccaccuccuc       60

cuccucggcc uccuccucgu ccuccucccc ggcgcccagg gccuccccgg cgucggccuc      120

acccccuccg ccgcccagac cgcccgccag caccccaaga ugcaccucgc ccacuccacc      180

cucaagcccg ccgcccaccu caucggcgac cccuccaagc agaacucccu ccucuggcgc      240

gccaacaccg accgcgccuu ccuccaggac ggcuucuccc ucuccaacaa cucccuccuc      300

guccccaccu ccggcaucua cuucgucuac ucccaggucg ucuucuccgg caaggccuac      360

ucccccaagg ccaccuccuc cccccucuac cucgcccacg agguccagcu cuucuccucc      420

caguaccccu uccacguccc ccuccucucc ucccagaaga uggucuaccc cggccuccag      480

gagcccuggc uccacuccau guaccacggc gccgccuucc agcucaccca gggcgaccag      540

cucuccaccc acaccgacgg caucccccac cucguccucu cccccuccac cgucuucuuc      600

ggcgccuucg cccucuga                                                    618


<210>  4685
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4685
augacacccc cugagagacu guuccuccca agggugcggg gcaccacucu ucaccuguug       60

uuacuggggc uacuccuggu ccuucugccg ggagcccagg guuugcccgg cguugggcuc      120

acgccuagcg cugcacaaac cgcccgccag cauccaaaga ugcaccuggc gcauuccaca      180

cugaaacccg cugcccaccu caucggagac ccuucuaagc agaacucauu acuguggcga      240

gcaaauacug aucgugccuu ucuucaggac ggcuucaguu ugagcaacaa uucccugcua      300

gugccaaccu cugguauuua cuuuguauau ucgcaagugg ucuucucagg gaaggcuuac      360

agccccaaag caacaaguuc cccucucuau cuggcccaug aagugcagcu guuuucuagc      420

caguacccau uccacguucc gcuuuugucc ucacagaaaa ugguguaucc cggacuccaa      480

gagccuuggc ugcacaguau guaccauggc gcugccuuuc aguuaaccca gggcgaucag      540

cugagcacuc acacagacgg gauaccacau cucguccuuu cucccuccac cguguucuuu      600

ggagcguucg cacuguga                                                    618


<210>  4686
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4686
augacccccc ccgagagacu guuccugccc agagugagag gcaccacccu gcaccugcug       60

cugcugggcc ugcugcuggu gcugcugccc ggcgcccagg gccugcccgg cgugggccug      120

acccccagcg ccgcccagac cgccagacag caccccaaga ugcaccuggc ccacagcacc      180

cugaagcccg ccgcccaccu gaucggcgac cccagcaagc agaacagccu gcuguggaga      240

gccaacaccg acagagccuu ccugcaggac ggcuucagcc ugagcaacaa cagccugcug      300

gugcccacca gcggcaucua cuucguguac agccaggugg uguucagcgg caaggccuac      360

agccccaagg ccaccagcag cccccuguac cuggcccacg aggugcagcu guucagcagc      420

caguaccccu uccacgugcc ccugcugagc agccagaaga ugguguaccc cggccugcag      480

gagcccuggc ugcacagcau guaccacggc gccgccuucc agcugaccca gggcgaccag      540

cugagcaccc acaccgacgg caucccccac cuggugcuga gccccagcac cguguucuuc      600

ggcgccuucg cccuguga                                                    618


<210>  4687
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4687
augacacccc cugagagacu guuccucccg cgggugcgcg gcaccacgcu gcaccuucug       60

cuccuggggc uucugcucgu ccugcugccc ggagcccagg gccucccugg gguuggacug      120

acccccagcg cugcccaaac agcgagacag cauccuaaga ugcaccuugc ucauuccacc      180

cugaaacccg ccgcccaccu caucggcgac ccuucuaagc agaacagccu gcuuuggcgg      240

gcuaauacag aucgcgccuu ucugcaggac ggguucuccc ucucuaacaa uagccugcug      300

gugccgaccu ccggaauuua cuuuguguau ucucaagucg uguucagcgg caaggcuuac      360

ucccccaaag ccacaagcuc uccucucuau cuggcgcaug aaguucagcu guuuuccagc      420

caguaccccu uccacgugcc ucuucucucu ucccagaaaa uggucuaucc cggccugcaa      480

gagccguggc uucacagcau guaccauggg gccgcuuuuc agcugaccca gggagaucag      540

cucucuacgc acaccgacgg caucccucau cuggugcugu cccccagcac aguuuucuuu      600

ggggccuucg cucucuga                                                    618


<210>  4688
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTalpha__Homo_sapiens__CAG47049

<400>  4688
augaccccac cagaaagacu auuucuacca agaguaagag gaacaacacu acaucuacua       60

cuacuaggac uacuacuagu auuacuacca ggagcacaag gucuaccagg aguaggauua      120

acaccuucag cagcccaaac agcaagacaa cacccaaaaa ugcaccuagc acacucaaca      180

cuaaaaccag cagcacacuu aauaggagac ccaucaaaac aaaacucccu ccuauggaga      240

gcaaacacag acagagcauu ccuacaagau ggauucucac ucucaaauaa cucauuacua      300

gucccaacau caggaauaua cuucguauac ucacaaguag uauucucagg aaaagcauac      360

ucaccaaaag caacaucauc accacuauac cuagcccacg aaguacaacu auuuucaucc      420

caauacccau uucacguacc acuacuauca ucacaaaaaa ugguauaccc aggacuacaa      480

gaaccauggc uacacucaau guaccacggu gcagcauucc aauuaaccca aggagaccaa      540

uuaucaacac auacagacgg aaucccacac cuaguccuau caccaucaac agucuucuuc      600

ggagcauucg cauuauaa                                                    618


<210>  4689
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTbeta__Homo_sapiens__Q06643

<400>  4689

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  4690
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTbeta__Homo_sapiens__AAA36191

<400>  4690
augggggcac uggggcugga gggcaggggu gggaggcucc aggggagggg uucccuccug       60

cuagcugugg caggagccac uucucuggug accuuguugc uggcggugcc uaucacuguc      120

cuggcugugc uggccuuagu gccccaggau cagggaggac ugguaacgga gacggccgac      180

cccggggcac aggcccagca aggacugggg uuucagaagc ugccagagga ggagccagaa      240

acagaucuca gccccgggcu cccagcugcc caccucauag gcgcuccgcu gaaggggcag      300

gggcuaggcu gggagacgac gaaggaacag gcguuucuga cgagcgggac gcaguucucg      360

gacgccgagg ggcuggcgcu cccgcaggac ggccucuauu accucuacug ucucgucggc      420

uaccggggcc gggcgccccc uggcggcggg gacccccagg gccgcucggu cacgcugcgc      480

agcucucugu accgggcggg gggcgccuac gggccgggca cucccgagcu gcugcucgag      540

ggcgccgaga cggugacucc agugcuggac ccggccagga gacaagggua cgggccucuc      600

ugguacacga gcgugggguu cggcggccug gugcagcucc ggaggggcga gaggguguac      660

gucaacauca gucaccccga uaugguggac uucgcgagag ggaagaccuu cuuuggggcc      720

gugauggugg gguga                                                       735


<210>  4691
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4691
augggcgccc uggggcucga gggccgcggg ggccggcugc aggggcgcgg cagccugcuc       60

cuggccgugg cgggcgccac cucccugguc acccuccugc uggccgugcc caucacggug      120

cucgccgucc uggcccuggu gccgcaggac cagggcgggc ucgugaccga gaccgcggac      180

cccggggccc aggcccagca gggccugggg uuccagaagc ugcccgagga ggagcccgag      240

accgaccuca gcccgggccu gcccgccgcg caccugaucg gcgcgccccu caaggggcag      300

ggccuggggu gggagacgac caaggagcag gccuuccuga ccuccggcac ccaguucagc      360

gacgccgagg gccucgcccu gccccaggac gggcuguacu accucuacug ccuggucggc      420

uaccgggggc gcgccccgcc cggcgggggc gacccccagg gccgguccgu gacgcugcgc      480

agcucccucu accgggccgg gggcgccuac gggcccggca ccccggagcu gcugcucgag      540

ggggccgaga ccgugacccc cguccuggac cccgcccgcc ggcagggcua cggcccccug      600

ugguacacga gcgugggguu cggcgggcuc gugcagcugc gccggggcga gcgcgucuac      660

gugaacaucu cccacccgga caugguggac uucgcgcggg ggaagaccuu cuucggcgcc      720

gucauggugg gcuga                                                       735


<210>  4692
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4692
augggcgccc ucggccucga gggccgcggc ggccgccucc agggccgcgg cucccuccuc       60

cucgccgucg ccggcgccac cucccucguc acccuccucc ucgccguccc caucaccguc      120

cucgccgucc ucgcccucgu cccccaggac cagggcggcc ucgucaccga gaccgccgac      180

cccggcgccc aggcccagca gggccucggc uuccagaagc uccccgagga ggagcccgag      240

accgaccucu cccccggccu ccccgccgcc caccucaucg gcgccccccu caagggccag      300

ggccucggcu gggagaccac caaggagcag gccuuccuca ccuccggcac ccaguucucc      360

gacgccgagg gccucgcccu cccccaggac ggccucuacu accucuacug ccucgucggc      420

uaccgcggcc gcgccccccc cggcggcggc gacccccagg gccgcuccgu cacccuccgc      480

uccucccucu accgcgccgg cggcgccuac ggccccggca cccccgagcu ccuccucgag      540

ggcgccgaga ccgucacccc cguccucgac cccgcccgcc gccagggcua cggcccccuc      600

ugguacaccu ccgucggcuu cggcggccuc guccagcucc gccgcggcga gcgcgucuac      660

gucaacaucu cccaccccga cauggucgac uucgcccgcg gcaagaccuu cuucggcgcc      720

gucauggucg gcuga                                                       735


<210>  4693
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4693
augggcgccc uggggcucga gggaagaggu ggcaggcuuc aggggcgggg aagccuguug       60

uuagcugugg caggcgccac cucccugguc acacuacucc uggcgguucc caucacugug      120

cuugcuguac uggccuuggu gccucaagac cagggugggc ucgucacgga aaccgcagau      180

ccaggagccc aggcucagca aggccugggc uuccagaagc ugccggagga ggaacccgaa      240

acagaccucu cuccuggguu accagcagcc caccugauug gagcuccccu uaaaggucag      300

ggcuuggggu gggagacuac caaggagcag gccuuucuga caucaggaac ccaauucagu      360

gaugcggaag gccuagcacu cccucaggac ggucuguacu aucuuuacug ccuggugggg      420

uaucgcggac gagccccacc cggcggcggg gauccucagg gacguagcgu uacuuugaga      480

uccucucucu acagggcugg uggcgccuau gggccaggaa caccggagcu guuacuggaa      540

ggcgcagaga ccgugacgcc cguccucgac ccugcucggc gccaggguua cgggccacuu      600

ugguauacuu cggugggcuu uggaggccug guacaauuga gaaggggaga gcggguuuac      660

gugaacauau cacaucccga uauggucgac uucgcccgcg ggaaaaccuu uuucggugcg      720

gugauggugg gcuga                                                       735


<210>  4694
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4694
augggcgccc ugggccugga gggcagaggc ggcagacugc agggcagagg cagccugcug       60

cuggccgugg ccggcgccac cagccuggug acccugcugc uggccgugcc caucaccgug      120

cuggccgugc uggcccuggu gccccaggac cagggcggcc uggugaccga gaccgccgac      180

cccggcgccc aggcccagca gggccugggc uuccagaagc ugcccgagga ggagcccgag      240

accgaccuga gccccggccu gcccgccgcc caccugaucg gcgccccccu gaagggccag      300

ggccugggcu gggagaccac caaggagcag gccuuccuga ccagcggcac ccaguucagc      360

gacgccgagg gccuggcccu gccccaggac ggccuguacu accuguacug ccuggugggc      420

uacagaggca gagccccccc cggcggcggc gacccccagg gcagaagcgu gacccugaga      480

agcagccugu acagagccgg cggcgccuac ggccccggca cccccgagcu gcugcuggag      540

ggcgccgaga ccgugacccc cgugcuggac cccgccagaa gacagggcua cggcccccug      600

ugguacacca gcgugggcuu cggcggccug gugcagcuga gaagaggcga gagaguguac      660

gugaacauca gccaccccga caugguggac uucgccagag gcaagaccuu cuucggcgcc      720

gugauggugg gcuga                                                       735


<210>  4695
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4695
augggcgccc uggggcucga gggaagaggc gggcggcugc agggacgcgg cagccuucug       60

cucgcugugg ccggggcgac cucccugguc acacuucugc ucgcuguucc caucacggug      120

cuggccgugc uggcccucgu cccucaagac cagggaggcc uggugaccga aacagcugau      180

ccgggcgccc aggcucagca agggcuugga uuccagaagc ugcccgagga ggaaccugaa      240

accgaccucu cucccggccu gccugccgcg caccuuauug gggcgccccu gaaaggacag      300

ggccucgggu gggagacaac caaggagcag gcuuuucuga caagcggaac ccaauucucc      360

gaugccgaag gccuggcucu cccucaggac ggccuguacu aucuuuacug ccugguuggg      420

uauagaggac gggccccgcc cggcggggga gauccucagg gccgcucugu gacgcucaga      480

agcucccugu accgggccgg gggagccuau ggccccggca ccccugagcu ucugcucgaa      540

ggggcugaga cagucacccc cgugcuggac ccggcccgca gacagggaua cggcccucug      600

ugguauacau cuguuggguu uggaggccuc gugcaacugc ggcgcgggga gagagucuac      660

gugaacauca gccaucccga uaugguggac uucgcucggg gcaaaaccuu uuucggagcc      720

gucaugguug gcuga                                                       735


<210>  4696
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTbeta__Homo_sapiens__AAA36191

<400>  4696
augggagcau uaggauuaga agguagagga ggaagauuac aaggaagagg aagucugcuu       60

cuagcaguug caggagcaac aaguuuagua acacuacuau uagcaguacc aauuacagua      120

uuagcaguau uagcacuagu accacaagau caaggaggau uaguaacaga aacagcagau      180

ccaggugcac aagcacaaca gggucuagga uuucaaaaau uaccagaaga agaaccagaa      240

acagauuuaa guccgggauu accugcagcu cauuuaauag gugcaccauu aaaaggacaa      300

ggauuaggau gggaaacaac aaaagaacaa gcauuuuuaa caagugguac acaauuuagu      360

gaugcagaag guuuagcauu accucaagac ggauuauauu auuuauauug cuuaguugga      420

uauagaggaa gagcaccacc agguggagga gauccacaag gaagaagugu aacauuaaga      480

ucaucauuau auagagcagg aggagcauac ggaccaggaa caccagaacu acuuuuagaa      540

ggagcagaaa caguaacacc aguauuagau ccagcaagaa gacaaggaua uggaccauua      600

ugguauacaa guguaggauu uggaggauua guucaauuaa gaagaggaga aagaguauau      660

guaaauauaa gccauccuga uaugguagau uuugcaagag gaaaaacauu uuuuggagca      720

guaaugguag gauaa                                                       735


<210>  4697
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LTbeta__Homo_sapiens__Q5STB2

<400>  4697

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  4698
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LTbeta__Homo_sapiens__BAC54938

<400>  4698
augggggcac uggggcugga gggcaggggu gggaggcucc aggggagggg uucccuccug       60

cuagcugugg caggagccac uucucuggug accuuguugc uggcggugcc uaucacuguc      120

cuggcugugc uggccuuagu gccccaggau cagggaggac ugguaacgga gacggccgac      180

cccggggcac aggcccagca aggacugggg uuucagaagc ugccagagga ggagccagaa      240

acagaucuca gccccgggcu cccagcugcc caccucauag gcgcuccgcu gaaggggcag      300

gggcuaggcu gggagacgac gaaggaacag gcguuucuga cgagcgggac gcaguucucg      360

gacgccgagg ggcuggcgcu cccgcaggac ggccucuauu accucuacug ucucgucggc      420

uaccggggcc gggcgccccc uggcggcggg gacccccagg gccgcucggu cacgcugcgc      480

agcucucugu accgggcggg gggcgccuac gggccgggca cucccgagcu gcugcucgag      540

ggcgccgaga cggugacucc agugcuggac ccggccagga gacaagggua cgggccucuc      600

ugguacacga gcgugggguu cggcggccug gugcagcucc ggaggggcga gaggguguac      660

gucaacauca gucaccccga uaugguggac uucgcgagag ggaagaccuu cuuuggggcc      720

gugauggugg gguga                                                       735


<210>  4699
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4699
augggcgccc uggggcucga gggccgcggg ggccggcugc aggggcgcgg cagccugcuc       60

cuggccgugg cgggcgccac cucccugguc acccuccugc uggccgugcc caucacggug      120

cucgccgucc uggcccuggu gccgcaggac cagggcgggc ucgugaccga gaccgcggac      180

cccggggccc aggcccagca gggccugggg uuccagaagc ugcccgagga ggagcccgag      240

accgaccuca gcccgggccu gcccgccgcg caccugaucg gcgcgccccu caaggggcag      300

ggccuggggu gggagacgac caaggagcag gccuuccuga ccuccggcac ccaguucagc      360

gacgccgagg gccucgcccu gccccaggac gggcuguacu accucuacug ccuggucggc      420

uaccgggggc gcgccccgcc cggcgggggc gacccccagg gccgguccgu gacgcugcgc      480

agcucccucu accgggccgg gggcgccuac gggcccggca ccccggagcu gcugcucgag      540

ggggccgaga ccgugacccc cguccuggac cccgcccgcc ggcagggcua cggcccccug      600

ugguacacga gcgugggguu cggcgggcuc gugcagcugc gccggggcga gcgcgucuac      660

gugaacaucu cccacccgga caugguggac uucgcgcggg ggaagaccuu cuucggcgcc      720

gucauggugg gcuga                                                       735


<210>  4700
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4700
augggcgccc ucggccucga gggccgcggc ggccgccucc agggccgcgg cucccuccuc       60

cucgccgucg ccggcgccac cucccucguc acccuccucc ucgccguccc caucaccguc      120

cucgccgucc ucgcccucgu cccccaggac cagggcggcc ucgucaccga gaccgccgac      180

cccggcgccc aggcccagca gggccucggc uuccagaagc uccccgagga ggagcccgag      240

accgaccucu cccccggccu ccccgccgcc caccucaucg gcgccccccu caagggccag      300

ggccucggcu gggagaccac caaggagcag gccuuccuca ccuccggcac ccaguucucc      360

gacgccgagg gccucgcccu cccccaggac ggccucuacu accucuacug ccucgucggc      420

uaccgcggcc gcgccccccc cggcggcggc gacccccagg gccgcuccgu cacccuccgc      480

uccucccucu accgcgccgg cggcgccuac ggccccggca cccccgagcu ccuccucgag      540

ggcgccgaga ccgucacccc cguccucgac cccgcccgcc gccagggcua cggcccccuc      600

ugguacaccu ccgucggcuu cggcggccuc guccagcucc gccgcggcga gcgcgucuac      660

gucaacaucu cccaccccga cauggucgac uucgcccgcg gcaagaccuu cuucggcgcc      720

gucauggucg gcuga                                                       735


<210>  4701
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4701
augggcgccc uggggcucga gggaagaggu ggcaggcuuc aggggcgggg aagccuguug       60

uuagcugugg caggcgccac cucccugguc acacuacucc uggcgguucc caucacugug      120

cuugcuguac uggccuuggu gccucaagac cagggugggc ucgucacgga aaccgcagau      180

ccaggagccc aggcucagca aggccugggc uuccagaagc ugccggagga ggaacccgaa      240

acagaccucu cuccuggguu accagcagcc caccugauug gagcuccccu uaaaggucag      300

ggcuuggggu gggagacuac caaggagcag gccuuucuga caucaggaac ccaauucagu      360

gaugcggaag gccuagcacu cccucaggac ggucuguacu aucuuuacug ccuggugggg      420

uaucgcggac gagccccacc cggcggcggg gauccucagg gacguagcgu uacuuugaga      480

uccucucucu acagggcugg uggcgccuau gggccaggaa caccggagcu guuacuggaa      540

ggcgcagaga ccgugacgcc cguccucgac ccugcucggc gccaggguua cgggccacuu      600

ugguauacuu cggugggcuu uggaggccug guacaauuga gaaggggaga gcggguuuac      660

gugaacauau cacaucccga uauggucgac uucgcccgcg ggaaaaccuu uuucggugcg      720

gugauggugg gcuga                                                       735


<210>  4702
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4702
augggcgccc ugggccugga gggcagaggc ggcagacugc agggcagagg cagccugcug       60

cuggccgugg ccggcgccac cagccuggug acccugcugc uggccgugcc caucaccgug      120

cuggccgugc uggcccuggu gccccaggac cagggcggcc uggugaccga gaccgccgac      180

cccggcgccc aggcccagca gggccugggc uuccagaagc ugcccgagga ggagcccgag      240

accgaccuga gccccggccu gcccgccgcc caccugaucg gcgccccccu gaagggccag      300

ggccugggcu gggagaccac caaggagcag gccuuccuga ccagcggcac ccaguucagc      360

gacgccgagg gccuggcccu gccccaggac ggccuguacu accuguacug ccuggugggc      420

uacagaggca gagccccccc cggcggcggc gacccccagg gcagaagcgu gacccugaga      480

agcagccugu acagagccgg cggcgccuac ggccccggca cccccgagcu gcugcuggag      540

ggcgccgaga ccgugacccc cgugcuggac cccgccagaa gacagggcua cggcccccug      600

ugguacacca gcgugggcuu cggcggccug gugcagcuga gaagaggcga gagaguguac      660

gugaacauca gccaccccga caugguggac uucgccagag gcaagaccuu cuucggcgcc      720

gugauggugg gcuga                                                       735


<210>  4703
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4703
augggcgccc uggggcucga gggaagaggc gggcggcugc agggacgcgg cagccuucug       60

cucgcugugg ccggggcgac cucccugguc acacuucugc ucgcuguucc caucacggug      120

cuggccgugc uggcccucgu cccucaagac cagggaggcc uggugaccga aacagcugau      180

ccgggcgccc aggcucagca agggcuugga uuccagaagc ugcccgagga ggaaccugaa      240

accgaccucu cucccggccu gccugccgcg caccuuauug gggcgccccu gaaaggacag      300

ggccucgggu gggagacaac caaggagcag gcuuuucuga caagcggaac ccaauucucc      360

gaugccgaag gccuggcucu cccucaggac ggccuguacu aucuuuacug ccugguuggg      420

uauagaggac gggccccgcc cggcggggga gauccucagg gccgcucugu gacgcucaga      480

agcucccugu accgggccgg gggagccuau ggccccggca ccccugagcu ucugcucgaa      540

ggggcugaga cagucacccc cgugcuggac ccggcccgca gacagggaua cggcccucug      600

ugguauacau cuguuggguu uggaggccuc gugcaacugc ggcgcgggga gagagucuac      660

gugaacauca gccaucccga uaugguggac uucgcucggg gcaaaaccuu uuucggagcc      720

gucaugguug gcuga                                                       735


<210>  4704
<211>  735
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LTbeta__Homo_sapiens__BAC54938

<400>  4704
augggugcac uaggauuaga aggaagagga gguagauuac aaggaagagg aaguuuacua       60

uuagcaguag caggggcaac aagucuagua acuuuauuac uagcaguacc aauaacagua      120

uuagcaguau uagcauuggu accacaagau caagguggau uaguaacaga aacugcagau      180

ccaggagcac aagcacaaca aggauuagga uuucaaaaau uaccagaaga agaaccugaa      240

acugauuuaa guccaggauu accagcagca cauuuaauag gagcaccacu aaaaggacaa      300

ggauuaggau gggaaacaac aaaagaacaa gcauuucuaa caaguggaac acaauucuca      360

gaugcagaag gauuagcauu accacaagau ggauuauacu auuuauacug uuuaguagga      420

uauagaggaa gagcaccgcc uggaggagga gauccacaag gaagaucagu aacacuacgc      480

aguagcuuau auagagcagg aggagcauac gguccaggaa caccagaauu auuguuagaa      540

ggagccgaaa caguaacacc aguuuuagau ccagcaagaa gacaaggaua ugguccauua      600

ugguauacaa guguagguuu ugguggauua guacaacuaa gaagaggaga aagaguauau      660

guaaauauau cacauccaga uauggucgau uuugcaagag gaaaaacauu uuuuggagca      720

guaaugguag gauaa                                                       735


<210>  4705
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  M-CSF__Homo_sapiens__P09603

<400>  4705

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  4706
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  M-CSF__Homo_sapiens__CCDS816.1

<400>  4706
augaccgcgc cgggcgccgc cgggcgcugc ccucccacga cauggcuggg cucccugcug       60

uuguuggucu gucuccuggc gagcaggagu aucaccgagg aggugucgga guacuguagc      120

cacaugauug ggaguggaca ccugcagucu cugcagcggc ugauugacag ucagauggag      180

accucgugcc aaauuacauu ugaguuugua gaccaggaac aguugaaaga uccagugugc      240

uaccuuaaga aggcauuucu ccugguacaa gacauaaugg aggacaccau gcgcuucaga      300

gauaacaccc ccaaugccau cgccauugug cagcugcagg aacucucuuu gaggcugaag      360

agcugcuuca ccaaggauua ugaagagcau gacaaggccu gcguccgaac uuucuaugag      420

acaccucucc aguugcugga gaaggucaag aaugucuuua augaaacaaa gaaucuccuu      480

gacaaggacu ggaauauuuu cagcaagaac ugcaacaaca gcuuugcuga augcuccagc      540

caagaugugg ugaccaagcc ugauugcaac ugccuguacc ccaaagccau cccuagcagu      600

gacccggccu cugucucccc ucaucagccc cucgcccccu ccauggcccc uguggcuggc      660

uugaccuggg aggacucuga gggaacugag ggcagcuccc ucuugccugg ugagcagccc      720

cugcacacag uggauccagg cagugccaag cagcggccac ccaggagcac cugccagagc      780

uuugagccgc cagagacccc aguugucaag gacagcacca ucgguggcuc accacagccu      840

cgccccucug ucggggccuu caaccccggg auggaggaua uucuugacuc ugcaaugggc      900

acuaauuggg ucccagaaga agccucugga gaggccagug agauucccgu accccaaggg      960

acagagcuuu cccccuccag gccaggaggg ggcagcaugc agacagagcc cgccagaccc     1020

agcaacuucc ucucagcauc uucuccacuc ccugcaucag caaagggcca acagccggca     1080

gauguaacug guaccgccuu gcccagggug ggccccguga ggcccacugg ccaggacugg     1140

aaucacaccc cccagaagac agaccaucca ucugcccugc ucagagaccc cccggagcca     1200

ggcucuccca ggaucucauc acugcgcccc cagggccuca gcaaccccuc cacccucucu     1260

gcucagccac agcuuuccag aagccacucc ucgggcagcg ugcugccccu uggggagcug     1320

gagggcagga ggagcaccag ggaucggagg agccccgcag agccagaagg aggaccagca     1380

agugaagggg cagccaggcc ccugccccgu uuuaacuccg uuccuuugac ugacacaggc     1440

caugagaggc aguccgaggg auccuucagc ccgcagcucc aggagucugu cuuccaccug     1500

cuggugccca gugucauccu ggucuugcug gccgucggag gccucuuguu cuacaggugg     1560

aggcggcgga gccaucaaga gccucagaga gcggauucuc ccuuggagca accagagggc     1620

agcccccuga cucaggauga cagacaggug gaacugccag uguag                     1665


<210>  4707
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4707
augaccgccc ccggcgccgc ggggcgcugc ccgcccacca cguggcuggg cagccuccug       60

cugcucgugu gccugcuggc cucccggagc aucaccgagg aggucuccga guacugcagc      120

cacaugaucg gguccggcca ccuccagagc cugcagcgcc ugaucgacuc ccagauggag      180

accagcugcc agaucaccuu cgaguucgug gaccaggagc agcucaagga ccccgugugc      240

uaccugaaga aggccuuccu gcucguccag gacaucaugg aggacacgau gcgguuccgc      300

gacaacaccc ccaacgccau cgccaucgug cagcugcagg agcugucccu ccggcugaag      360

uccugcuuca ccaaggacua cgaggagcac gacaaggcgu gcgugcgcac cuucuacgag      420

acgccgcugc agcuccugga gaaggucaag aacguguuca acgagaccaa gaaccugcuc      480

gacaaggacu ggaacaucuu cuccaagaac ugcaacaaca gcuucgccga gugcuccagc      540

caggacgugg ucaccaagcc cgacugcaac ugccuguacc ccaaggccau ccccuccagc      600

gacccggccu ccgugagccc ccaccagccc cuggcgcccu ccauggcccc gguggccggg      660

cucaccuggg aggacagcga gggcacggag ggcagcuccc ugcugcccgg ggagcagccc      720

cuccacaccg ucgaccccgg cagcgccaag cagcggccgc cccgcuccac gugccagagc      780

uucgagccgc ccgagacccc cguggugaag gacuccacca ucgggggcag cccccagccc      840

cggcccuccg ucggggccuu caacccgggc auggaggaca uccuggacag cgcgaugggc      900

accaacuggg ugcccgagga ggccuccggg gaggccagcg agauccccgu gccccagggc      960

accgagcugu ccccgagccg ccccgggggc ggcuccaugc agaccgagcc cgcccggccg     1020

agcaacuucc ucuccgccag cuccccgcug cccgcgagcg ccaaggggca gcagcccgcc     1080

gacgucacgg gcaccgcccu gccccgcgug gggcccgugc ggcccaccgg ccaggacugg     1140

aaccacacgc cccagaagac cgaccacccg uccgcccucc ugcgcgaccc gcccgagccc     1200

gggagccccc ggaucagcuc ccugcgcccc cagggccuca gcaaccccuc cacccugagc     1260

gcgcagcccc agcugucccg gagccacucc agcggcuccg uccucccgcu gggggagcug     1320

gagggccgcc ggagcacccg cgaccggcgc ucccccgccg agcccgaggg cgggcccgcc     1380

agcgaggggg ccgcccgccc gcucccccgg uucaacuccg ugccccugac cgacacgggc     1440

cacgagcgcc agagcgaggg cuccuucagc ccccagcugc aggaguccgu guuccaccuc     1500

cuggucccga gcgugauccu gguccuccug gcggucgggg gccugcuguu cuaccggugg     1560

cgccggcgca gccaccagga gccccagcgg gccgacagcc cccucgagca gccggagggg     1620

agcccccuga cccaggacga ccgccaggug gagcugcccg uguga                     1665


<210>  4708
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4708
augaccgccc ccggcgccgc cggccgcugc ccccccacca ccuggcucgg cucccuccuc       60

cuccucgucu gccuccucgc cucccgcucc aucaccgagg aggucuccga guacugcucc      120

cacaugaucg gcuccggcca ccuccagucc cuccagcgcc ucaucgacuc ccagauggag      180

accuccugcc agaucaccuu cgaguucguc gaccaggagc agcucaagga ccccgucugc      240

uaccucaaga aggccuuccu ccucguccag gacaucaugg aggacaccau gcgcuuccgc      300

gacaacaccc ccaacgccau cgccaucguc cagcuccagg agcucucccu ccgccucaag      360

uccugcuuca ccaaggacua cgaggagcac gacaaggccu gcguccgcac cuucuacgag      420

accccccucc agcuccucga gaaggucaag aacgucuuca acgagaccaa gaaccuccuc      480

gacaaggacu ggaacaucuu cuccaagaac ugcaacaacu ccuucgccga gugcuccucc      540

caggacgucg ucaccaagcc cgacugcaac ugccucuacc ccaaggccau ccccuccucc      600

gaccccgccu ccgucucccc ccaccagccc cucgcccccu ccauggcccc cgucgccggc      660

cucaccuggg aggacuccga gggcaccgag ggcuccuccc uccuccccgg cgagcagccc      720

cuccacaccg ucgaccccgg cuccgccaag cagcgccccc cccgcuccac cugccagucc      780

uucgagcccc ccgagacccc cgucgucaag gacuccacca ucggcggcuc cccccagccc      840

cgccccuccg ucggcgccuu caaccccggc auggaggaca uccucgacuc cgccaugggc      900

accaacuggg uccccgagga ggccuccggc gaggccuccg agauccccgu cccccagggc      960

accgagcucu cccccucccg ccccggcggc ggcuccaugc agaccgagcc cgcccgcccc     1020

uccaacuucc ucuccgccuc cuccccccuc cccgccuccg ccaagggcca gcagcccgcc     1080

gacgucaccg gcaccgcccu cccccgcguc ggccccgucc gccccaccgg ccaggacugg     1140

aaccacaccc cccagaagac cgaccacccc uccgcccucc uccgcgaccc ccccgagccc     1200

ggcucccccc gcaucuccuc ccuccgcccc cagggccucu ccaaccccuc cacccucucc     1260

gcccagcccc agcucucccg cucccacucc uccggcuccg uccucccccu cggcgagcuc     1320

gagggccgcc gcuccacccg cgaccgccgc ucccccgccg agcccgaggg cggccccgcc     1380

uccgagggcg ccgcccgccc ccucccccgc uucaacuccg ucccccucac cgacaccggc     1440

cacgagcgcc aguccgaggg cuccuucucc ccccagcucc aggaguccgu cuuccaccuc     1500

cucguccccu ccgucauccu cguccuccuc gccgucggcg gccuccucuu cuaccgcugg     1560

cgccgccgcu cccaccagga gccccagcgc gccgacuccc cccucgagca gcccgagggc     1620

uccccccuca cccaggacga ccgccagguc gagcuccccg ucuga                     1665


<210>  4709
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4709
augaccgccc ccggcgcugc agggagaugc ccuccaacaa cuuggcuggg aagccuccuu       60

cuguuggugu guuuacuggc cuccaggucu aucacggagg aagucucaga guacugcagu      120

cacaugauug guagcggcca ucuacagucc cuccaacggc ugauagacuc ucagauggaa      180

accucguguc agaucacauu cgaguuuguu gaucaggaac aacuuaagga cccggugugc      240

uaucugaaaa aggcguucuu gcucguacag gauauuaugg aggacacuau gcgcuuucga      300

gauaacaccc ccaaugcuau cgccauugug cagcugcagg agcugucacu ccguuuaaaa      360

agcuguuuca caaaggacua cgaagaacac gauaaagcau gcgucagaac cuuuuaugaa      420

acuccucugc aacuuuugga gaaggugaag aacguuuuca augagaccaa aaaccugcua      480

gacaaggauu ggaauaucuu uaguaaaaac uguaauaacu ccuucgccga augcucuagc      540

caggacgugg ucacaaagcc agauuguaau ugccucuacc ccaaagcuau accuuccuca      600

gacccagcaa gugugagccc ccaucagccu cuggccccau cuauggcucc gguagccggg      660

cuuacguggg aggauuccga aggaacugag ggcucaagcc uguugcccgg ugaacagccu      720

cuccacaccg uugacccagg gagugcgaag caaaggcccc cucggucuac augucagucc      780

uuugagccac ccgagacucc gguggucaag gacagcacca ucggaggcuc gccucagccc      840

cgcccaucug ugggcgcauu caacccuggg auggaagaua uucuggacuc cgccauggga      900

acaaauuggg ugcccgagga ggcuucaggu gaggccagug aaaucccagu cccccaaggc      960

accgaguuaa gcccuuccag accaggggga ggcucuaugc agacggagcc ggcaaggccc     1020

agcaacuuuc ugucagcuag uuccccucuc ccagccagcg cgaaagguca gcagcccgcc     1080

gauguuacug ggacagcacu uccucgggug ggaccaguac gccccaccgg ccaagacugg     1140

aaucauacuc cgcagaagac agaucacccu ucugcucugu ugcgagaccc acccgaaccu     1200

ggcucaccca gaauuaguag ccuaaggcca caggggcugu ccaacccuuc uacccucucg     1260

gcccagcccc aacugagccg gucccacuca aguggaucug ugcuuccacu gggugaguug     1320

gaaggccguc gcagcacgag agauaggcgg uccccggcug agccugaagg gggacccgcc     1380

ucagagggcg cagcccgacc acucccccgc uucaauagcg ucccucugac cgacacaggu     1440

caugagagac agucugaagg guccuuuagu ccacaguuac aggagagcgu guuccaucug     1500

cuaguucccu cugugauccu cguccugcuu gcugugggcg gauugcuguu cuauaggugg     1560

cggcgcagau cccaccaaga accucagagg gcggauucac cgcucgagca gccagagggc     1620

aguccccuga cucaggacga ucgucaagua gaacuuccug uuuga                     1665


<210>  4710
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4710
augaccgccc ccggcgccgc cggcagaugc ccccccacca ccuggcuggg cagccugcug       60

cugcuggugu gccugcuggc cagcagaagc aucaccgagg aggugagcga guacugcagc      120

cacaugaucg gcagcggcca ccugcagagc cugcagagac ugaucgacag ccagauggag      180

accagcugcc agaucaccuu cgaguucgug gaccaggagc agcugaagga ccccgugugc      240

uaccugaaga aggccuuccu gcuggugcag gacaucaugg aggacaccau gagauucaga      300

gacaacaccc ccaacgccau cgccaucgug cagcugcagg agcugagccu gagacugaag      360

agcugcuuca ccaaggacua cgaggagcac gacaaggccu gcgugagaac cuucuacgag      420

accccccugc agcugcugga gaaggugaag aacguguuca acgagaccaa gaaccugcug      480

gacaaggacu ggaacaucuu cagcaagaac ugcaacaaca gcuucgccga gugcagcagc      540

caggacgugg ugaccaagcc cgacugcaac ugccuguacc ccaaggccau ccccagcagc      600

gaccccgcca gcgugagccc ccaccagccc cuggccccca gcauggcccc cguggccggc      660

cugaccuggg aggacagcga gggcaccgag ggcagcagcc ugcugcccgg cgagcagccc      720

cugcacaccg uggaccccgg cagcgccaag cagagacccc ccagaagcac cugccagagc      780

uucgagcccc ccgagacccc cguggugaag gacagcacca ucggcggcag cccccagccc      840

agacccagcg ugggcgccuu caaccccggc auggaggaca uccuggacag cgccaugggc      900

accaacuggg ugcccgagga ggccagcggc gaggccagcg agauccccgu gccccagggc      960

accgagcuga gccccagcag acccggcggc ggcagcaugc agaccgagcc cgccagaccc     1020

agcaacuucc ugagcgccag cagcccccug cccgccagcg ccaagggcca gcagcccgcc     1080

gacgugaccg gcaccgcccu gcccagagug ggccccguga gacccaccgg ccaggacugg     1140

aaccacaccc cccagaagac cgaccacccc agcgcccugc ugagagaccc ccccgagccc     1200

ggcagcccca gaaucagcag ccugagaccc cagggccuga gcaaccccag cacccugagc     1260

gcccagcccc agcugagcag aagccacagc agcggcagcg ugcugccccu gggcgagcug     1320

gagggcagaa gaagcaccag agacagaaga agccccgccg agcccgaggg cggccccgcc     1380

agcgagggcg ccgccagacc ccugcccaga uucaacagcg ugccccugac cgacaccggc     1440

cacgagagac agagcgaggg cagcuucagc ccccagcugc aggagagcgu guuccaccug     1500

cuggugccca gcgugauccu ggugcugcug gccgugggcg gccugcuguu cuacagaugg     1560

agaagaagaa gccaccagga gccccagaga gccgacagcc cccuggagca gcccgagggc     1620

agcccccuga cccaggacga cagacaggug gagcugcccg uguga                     1665


<210>  4711
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4711
augaccgccc ccggcgcugc cgggagaugc ccuccgacaa cguggcuggg aagccuccug       60

cuucuggugu gucuccuggc gucccggucu aucaccgagg aagucagcga guacugcucc      120

cacaugauug gcucugggca ucuucagagc cugcaacgcc ucaucgacuc ccagauggaa      180

acaucuuguc agauuaccuu cgaguuuguu gaucaggaac aacugaagga ccccgugugc      240

uaucugaaaa aggcuuuccu ccuggugcag gauaucaugg aggacacaau gagauuucgg      300

gauaacaccc cuaaugccau ugccaucguc cagcuucagg agcugagccu ccgccugaaa      360

uccuguuuca caaaggacua cgaggaacac gauaaggcuu gcgugagaac cuuuuaugaa      420

acgccccuuc aacugcucga gaaaguuaag aacguguuca augagaccaa aaaccugcug      480

gacaaggauu ggaauaucuu uagcaaaaac uguaauaacu cuuucgccga augcuccagc      540

caggacgucg ugacaaagcc ugauuguaau ugccucuacc ccaaagcuau uccuucuucc      600

gacccggcca gcguuucucc ccaucagccu cuggcgcccu ccauggcccc uguggcugga      660

cuuaccuggg aggauagcga aggcacagag ggguccucuc ugcuccccgg agaacagccg      720

cugcacaccg ucgacccugg cagcgccaag caacggcccc cucgcuccac gugucagagc      780

uuugagccuc ccgagacacc cguggugaag gacucuacca ucggcggguc cccgcagccc      840

agaccuagcg ucggagcuuu caaccccggc auggaagaua uucuugacuc ugccaugggg      900

acaaauuggg uuccugagga agcgagcgga gaggccuccg aaauccccgu gccgcaaggc      960

accgagcugu cuccuagccg gcccggggga ggcuccaugc agaccgagcc ugcucgcccc     1020

agcaacuuuc ucucugccuc cagcccucug cccgcuucug ccaaaggcca gcagccggcc     1080

gaugugacag ggacggcucu gccuagaguc ggacccgugc ggcccaccgg ccaagacugg     1140

aaucauacac cucagaagac cgaucacccg uccgcgcucc ugcgcgaucc cccugaaccc     1200

gggagcccua gaauuuccuc ucuucggccc cagggacuga gcaacccuuc cacacucucu     1260

gcccagcccc aacugagccg cucccacagc ucuggcuccg uucuuccgcu gggggagcuc     1320

gaaggaagac ggagcaccag agaccgccgg ucuccugcug agcccgaagg cggcccugcc     1380

uccgaggggg ccgcuagacc ccugccgcgc uucaauagcg ugccucugac ggacacagga     1440

caugagcggc agucugaagg cagcuuuagc ccccagcucc aggaguccgu cuuccaucug     1500

cuugugccuu cuguuauccu ggugcuccug gccgucgggg gacugcuuuu cuauagaugg     1560

cgccggagau cccaccaaga accccagcgc gcggauagcc cccucgagca gccugagggc     1620

uccccgcuga cccaggacga ucggcaagug gaacugcccg ucuga                     1665


<210>  4712
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       M-CSF__Homo_sapiens__CCDS816.1

<400>  4712
augacggcac caggagcagc cggcagaugc ccuccaacua cauggcuagg aucauuauua       60

uuacucguau gcuugcuagc uucaagauca aucacugaag aaguauccga auauuguuca      120

cauaugauug gauccggcca ucuacaaagc uuacaaagac uuauagauuc acaaauggaa      180

acaaguugcc aaauaacauu ugaauuugua gaccaagaac aauuaaaaga uccaguuugu      240

uaucucaaaa aggcauuuuu auuaguacaa gacauaaugg aagacacaau gagauucaga      300

gauaacacac caaacgcuau agcuauagua caacuacaag aacuaucucu ucgccuuaaa      360

ucauguuuua caaaagauua cgaagaacau gauaaagcau guguaagaac cuuuuacgaa      420

acaccacuac aacuauuaga aaaaguuaaa aacguauuca acgaaacaaa aaaucuuuua      480

gauaaagacu ggaacauuuu uucaaaaaac ugcaauaauu cauucgcaga auguucauca      540

caagacguag uaaccaaacc agacuguaac ugccuauacc ccaaagcuau accaaguucu      600

gauccagcca gcguuucacc ucaccaacca cuagcaccuu caauggcacc ugucgcaggc      660

cuaacauggg aagacucaga gggaaccgaa ggaaguucuc uacuaccagg agaacaaccu      720

uuacauaccg uagacccugg cucagcaaaa caaagaccuc cacgaucuac augccaauca      780

uuugagccac cagaaacacc uguaguaaaa gauucuacaa uaggcggaag cccacaacca      840

cguccaucug ucggugccuu caaucccgga auggaagaca uuuuagauuc agcaaugggu      900

acaaauuggg uaccagaaga agcauccgga gaagcauccg aaauaccagu uccacaagga      960

acagaacuua guccaucuag accaggagga ggauccaugc aaacugaacc cgcaagacca     1020

ucaaacuuuu uaucagcauc auccccauua ccagcauccg caaaaggcca acaaccagca     1080

gacgucacag gaacugcuuu accacgagua ggaccaguaa gaccuacagg ucaagauugg     1140

aaucauaccc cacaaaaaac agaucauccc ucagcccuac uaagagaccc accagaacca     1200

gguucaccaa gaauuucuag ucuaagacca caaggauuau caaauccuuc aacauuaucc     1260

gcucaaccuc aauuaucuag aucucauagc ucaggaagcg uucucccccu uggagaacuc     1320

gaaggaagaa gaucuacacg agaucgaaga ucaccagcag aaccugaagg cggcccagca     1380

ucagaaggug cagcacgucc acuaccaaga uuuaacucug uaccacuaac ugauacagga     1440

caugaaagac aaucagaagg aaguuucuca ccccaacuac aagaaucagu auuccauuua     1500

cuuguaccaa guguaauucu aguccuucua gcaguuggag gcuuacucuu cuacagaugg     1560

agacgacguu cccaucaaga accacaacga gcagauucac cacuagaaca accugaagga     1620

ucaccacuaa cccaagacga cagacaagua gaacugccag uauaa                     1665


<210>  4713
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MIF__Homo_sapiens__A6MUU8

<400>  4713

Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp Gly 
1               5                   10                  15      


Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys Pro 
            20                  25                  30          


Pro Gln Tyr Ile Ala Val Gln Val Val Pro Asp Gln Leu Met Ala Phe 
        35                  40                  45              


Gly Gly Ser Ser Glu Pro Trp Ala Phe Cys Ser Leu His Ser Ile Gly 
    50                  55                  60                  


Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu Phe Gly 
65                  70                  75                  80  


Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr Ile Asn 
                85                  90                  95      


Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser Pro Phe 
            100                 105                 110         


Ala 
    


<210>  4714
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MIF__Homo_sapiens__ABR12395

<400>  4714
auguucaucg uaaacaccaa cgugccccgc gccuccgugc cggacggguu ccucuccgag       60

cucacccagc agcuggcgca ggccaccggc aagccccccc aguacauugc ggugcaagug      120

gucccggacc agcucauggc cuuugggggg uccagcgaac cgugggcguu uugcagccug      180

cacagcauug gcaaaaucgg cggcgcgcag aaccgcuccu acagcaagcu gcuguucggc      240

cugcuggccg agcgccugcg caucagcccg gacaggguuu acaucaacua uuacgacaug      300

aacgcggcca auguggggug gaacaacucc cccuuugccu aa                         342


<210>  4715
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MIF__Homo_sapiens__ABR12395

<400>  4715
auguucaucg ugaacaccaa cgucccccgc gccagcgugc cggacggcuu ccuguccgag       60

cucacccagc agcuggccca ggcgacgggg aagccgcccc aguacaucgc cgugcagguc      120

gugcccgacc agcugauggc cuucggcggg agcuccgagc ccugggccuu cugcagccuc      180

cacuccaucg gcaagaucgg gggcgcccag aaccggagcu acuccaagcu gcuguucggc      240

cuccuggcgg agcgccugcg gaucagcccc gaccgcgugu acaucaacua cuacgacaug      300

aacgccgcca acgucgggug gaacaacucc cccuucgccu ga                         342


<210>  4716
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MIF__Homo_sapiens__ABR12395

<400>  4716
auguucaucg ucaacaccaa cgucccccgc gccuccgucc ccgacggcuu ccucuccgag       60

cucacccagc agcucgccca ggccaccggc aagccccccc aguacaucgc cguccagguc      120

guccccgacc agcucauggc cuucggcggc uccuccgagc ccugggccuu cugcucccuc      180

cacuccaucg gcaagaucgg cggcgcccag aaccgcuccu acuccaagcu ccucuucggc      240

cuccucgccg agcgccuccg caucuccccc gaccgcgucu acaucaacua cuacgacaug      300

aacgccgcca acgucggcug gaacaacucc cccuucgccu ga                         342


<210>  4717
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MIF__Homo_sapiens__ABR12395

<400>  4717
auguucaucg ugaacaccaa uguccccaga gccagcguuc cugacggcuu ucuguccgag       60

cucacacagc aacuugcuca ggcaacuggg aagccaccgc aguacauugc cgugcaggua      120

gugcccgauc aacugauggc guucggaggu ucuucagaac cuugggcuuu uugcaguuug      180

cacagcauag gcaaaaucgg gggagcccag aacagguccu auucuaaguu acuguucggc      240

cuacucgcag agcggcugcg cauuucgcca gaccgagucu acaucaauua uuacgauaug      300

aacgccgcua auguggguug gaacaauuca cccuuugcau ga                         342


<210>  4718
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MIF__Homo_sapiens__ABR12395

<400>  4718
auguucaucg ugaacaccaa cgugcccaga gccagcgugc ccgacggcuu ccugagcgag       60

cugacccagc agcuggccca ggccaccggc aagccccccc aguacaucgc cgugcaggug      120

gugcccgacc agcugauggc cuucggcggc agcagcgagc ccugggccuu cugcagccug      180

cacagcaucg gcaagaucgg cggcgcccag aacagaagcu acagcaagcu gcuguucggc      240

cugcuggccg agagacugag aaucagcccc gacagagugu acaucaacua cuacgacaug      300

aacgccgcca acgugggcug gaacaacagc cccuucgccu ga                         342


<210>  4719
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MIF__Homo_sapiens__ABR12395

<400>  4719
auguucaucg ugaacaccaa uguccccaga gccagcguuc cugacggcuu ucuguccgag       60

cucacacagc aacuggcuca ggccacgggg aagccgcccc aguacauugc gguccaggug      120

gugccugauc aacuuauggc uuucggaggc ucuagcgaac ccugggccuu uugcucccug      180

cacucuaucg ggaaaauugg aggcgcccag aaccggagcu auuccaagcu ccuguucggg      240

cuucuggcug agcgccucag aaucucuccu gaccgggugu acauuaauua uuacgauaug      300

aacgccgcua auguuggaug gaacaauagc cccuuugccu ga                         342


<210>  4720
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       MIF__Homo_sapiens__ABR12395

<400>  4720
auguucauag uaaauacaaa uguaccaaga gcaagcguac cagauggauu ucuaucagaa       60

uuaacacaac aauuagcaca agcaacagga aaaccaccac aauauauagc aguacaagua      120

guaccagauc aauuaauggc auucggagga ucaagcgaac caugggcauu uugcucacua      180

cauagcauag gaaaaauagg aggagcacaa aauagaucau acucaaaauu acuauuugga      240

uuacuagcag aaagacuaag aauaucacca gauagaguuu acauaaacua uuacgauaug      300

aaugcagcaa acguaggaug gaacaauagc ccauucgcau aa                         342


<210>  4721
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MIF__Homo_sapiens__P14174

<400>  4721

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  4722
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MIF__Homo_sapiens__AAA21814

<400>  4722
augccgaugu ucaucguaaa caccaacgug ccccgcgccu ccgugccgga cggguuccuc       60

uccgagcuca cccagcagcu ggcgcaggcc accggcaagc ccccccagua caucgcggug      120

cacguggucc cggaccagcu cauggccuuc ggcggcucca gcgagccgug cgcgcucugc      180

agccugcaca gcaucggcaa gaucggcggc gcgcagaacc gcuccuacag caagcugcug      240

ugcggccugc uggccgagcg ccugcgcauc agcccggaca gggucuacau caacuauuac      300

gacaugaacg cggccaaugu gggcuggaac aacuccaccu ucgccuaa                   348


<210>  4723
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MIF__Homo_sapiens__AAA21814

<400>  4723
augcccaugu ucaucgugaa caccaacguc ccgcgcgcca gcgugcccga cggcuuccug       60

uccgagcuca cccagcagcu ggcccaggcg acggggaagc cgccccagua caucgccgug      120

cacgucgugc ccgaccagcu gauggccuuc ggcgggagcu ccgagcccug cgcccucugc      180

agccugcacu ccaucggcaa gaucgggggc gcccagaacc ggagcuacuc caagcugcuc      240

ugcggccugc uggcggagcg ccuccggauc agccccgacc gcguguacau caacuacuac      300

gacaugaacg ccgccaacgu cggguggaac aacuccaccu ucgccuga                   348


<210>  4724
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MIF__Homo_sapiens__AAA21814

<400>  4724
augcccaugu ucaucgucaa caccaacguc ccccgcgccu ccguccccga cggcuuccuc       60

uccgagcuca cccagcagcu cgcccaggcc accggcaagc ccccccagua caucgccguc      120

cacgucgucc ccgaccagcu cauggccuuc ggcggcuccu ccgagcccug cgcccucugc      180

ucccuccacu ccaucggcaa gaucggcggc gcccagaacc gcuccuacuc caagcuccuc      240

ugcggccucc ucgccgagcg ccuccgcauc ucccccgacc gcgucuacau caacuacuac      300

gacaugaacg ccgccaacgu cggcuggaac aacuccaccu ucgccuga                   348


<210>  4725
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MIF__Homo_sapiens__AAA21814

<400>  4725
augcccaugu ucaucgugaa caccaauguc ccuagagcca gcguuccaga cggcuuucug       60

uccgagcuca cacagcaacu ugcucaggca acugggaagc cgccccagua cauugccgug      120

cacguagugc cugaucagcu gauggcguuc ggagguucuu cagaaccaug cgcuuugugu      180

aguuuacaua gcauaggcaa aaucggggga gcccaaaaca gguccuauuc uaagcugcua      240

ugcggccucc uggcagagcg gcuucgcauu ucgcccgacc gagucuacau caauuauuac      300

gauaugaacg ccgcuaaugu ggguuggaac aauucaacgu uugcauga                   348


<210>  4726
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MIF__Homo_sapiens__AAA21814

<400>  4726
augcccaugu ucaucgugaa caccaacgug cccagagcca gcgugcccga cggcuuccug       60

agcgagcuga cccagcagcu ggcccaggcc accggcaagc ccccccagua caucgccgug      120

cacguggugc ccgaccagcu gauggccuuc ggcggcagca gcgagcccug cgcccugugc      180

agccugcaca gcaucggcaa gaucggcggc gcccagaaca gaagcuacag caagcugcug      240

ugcggccugc uggccgagag acugagaauc agccccgaca gaguguacau caacuacuac      300

gacaugaacg ccgccaacgu gggcuggaac aacagcaccu ucgccuga                   348


<210>  4727
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MIF__Homo_sapiens__AAA21814

<400>  4727
augcccaugu ucaucgugaa caccaauguc ccuagagcca gcguuccgga cggcuuucug       60

uccgagcuca cacagcaacu ggcucaggcc acggggaagc ccccucagua cauugcggug      120

cacguggucc ccgaucagcu uauggcuuuc ggaggcucua gcgaaccuug cgcccugugu      180

ucccuccauu cuaucgggaa aauuggaggc gcccaaaacc ggagcuauuc caagcugcuu      240

ugcgggcugc ucgcugagcg ccugagaauc ucucccgacc ggguguacau uaauuauuac      300

gauaugaacg ccgcuaaugu uggauggaac aauagcaccu uugccuga                   348


<210>  4728
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       MIF__Homo_sapiens__AAA21814

<400>  4728
augccaaugu ucauaguaaa cacaaaugua ccaagagcau caguaccaga cggauuccua       60

ucagaauuaa cacaacaacu agcacaagca acaggaaaac caccacaaua cauagcagua      120

cacguaguac cagaccaacu aauggcauuc ggaggaucau cagaaccaug cgcacuaugc      180

ucacuacacu caauaggaaa aauaggagga gcacaaaaca gaucauacuc aaaauuacua      240

ugcggacuac uagcagaaag acuaagaaua ucaccagaca gaguauacau aaacuauuac      300

gacaugaacg cagcaaacgu aggauggaac aauucaacau ucgcauaa                   348


<210>  4729
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OSM__Homo_sapiens__P13725

<400>  4729

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  4730
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OSM__Homo_sapiens__AAA36388

<400>  4730
auggggguac ugcucacaca gaggacgcug cucagucugg uccuugcacu ccuguuucca       60

agcauggcga gcauggcggc uauaggcagc ugcucgaaag aguaccgcgu gcuccuuggc      120

cagcuccaga agcagacaga ucucaugcag gacaccagca gacuccugga ccccuauaua      180

cguauccaag gccuggaugu uccuaaacug agagagcacu gcagggagcg ccccggggcc      240

uuccccagug aggagacccu gagggggcug ggcaggcggg gcuuccugca gacccucaau      300

gccacacugg gcugcguccu gcacagacug gccgacuuag agcagcgccu ccccaaggcc      360

caggauuugg agaggucugg gcugaacauc gaggacuugg agaagcugca gauggcgagg      420

ccgaacaucc ucgggcucag gaacaacauc uacugcaugg cccagcugcu ggacaacuca      480

gacacggcug agcccacgaa ggcuggccgg ggggccucuc agccgcccac ccccaccccu      540

gccucggaug cuuuucagcg caagcuggag ggcugcaggu uccugcaugg cuaccaucgc      600

uucaugcacu caguggggcg ggucuucagc aagugggggg agagcccgaa ccggagccgg      660

agacacagcc cccaccaggc ccugaggaag ggggugcgca ggaccagacc cuccaggaaa      720

ggcaagagac ucaugaccag gggacagcug ccccgguag                             759


<210>  4731
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OSM__Homo_sapiens__AAA36388

<400>  4731
augggcgugc ugcucaccca gcgcacccug cugagccucg uccuggcccu ccuguucccc       60

uccauggcca gcauggcggc caucgggucc ugcagcaagg aguaccgggu gcugcugggc      120

cagcuccaga agcagacgga ccugaugcag gacaccuccc gccugcucga cccguacauc      180

cggauccagg ggcuggacgu gcccaagcug cgcgagcacu gccgggagcg ccccggcgcc      240

uuccccagcg aggagacccu ccgggggcug ggccgccggg gcuuccugca gacccucaac      300

gccacgcugg ggugcguccu gcaccgccuc gccgaccugg agcagcggcu gccgaaggcg      360

caggaccucg agcgcuccgg ccugaacauc gaggaccugg agaagcucca gauggcccgg      420

cccaacaucc uggggcugcg caacaacauc uacugcaugg cccagcuccu ggacaacagc      480

gacaccgccg agcccaccaa ggcgggccgc ggggccuccc agcccccgac ccccacgccc      540

gccagcgacg ccuuccagcg gaagcuggag ggcugccggu uccuccacgg cuaccaccgc      600

uucaugcacu ccguggggcg gguguucagc aaguggggcg agucccccaa ccgcagccgg      660

cgccacuccc cgcaccaggc ccugcgcaag gggguccggc gcacccggcc cagccgcaag      720

ggcaagcggc ugaugacccg cggccagcuc ccccgguga                             759


<210>  4732
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OSM__Homo_sapiens__AAA36388

<400>  4732
augggcgucc uccucaccca gcgcacccuc cucucccucg uccucgcccu ccucuucccc       60

uccauggccu ccauggccgc caucggcucc ugcuccaagg aguaccgcgu ccuccucggc      120

cagcuccaga agcagaccga ccucaugcag gacaccuccc gccuccucga ccccuacauc      180

cgcauccagg gccucgacgu ccccaagcuc cgcgagcacu gccgcgagcg ccccggcgcc      240

uuccccuccg aggagacccu ccgcggccuc ggccgccgcg gcuuccucca gacccucaac      300

gccacccucg gcugcguccu ccaccgccuc gccgaccucg agcagcgccu ccccaaggcc      360

caggaccucg agcgcuccgg ccucaacauc gaggaccucg agaagcucca gauggcccgc      420

cccaacaucc ucggccuccg caacaacauc uacugcaugg cccagcuccu cgacaacucc      480

gacaccgccg agcccaccaa ggccggccgc ggcgccuccc agccccccac ccccaccccc      540

gccuccgacg ccuuccagcg caagcucgag ggcugccgcu uccuccacgg cuaccaccgc      600

uucaugcacu ccgucggccg cgucuucucc aaguggggcg agucccccaa ccgcucccgc      660

cgccacuccc cccaccaggc ccuccgcaag ggcguccgcc gcacccgccc cucccgcaag      720

ggcaagcgcc ucaugacccg cggccagcuc ccccgcuga                             759


<210>  4733
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OSM__Homo_sapiens__AAA36388

<400>  4733
augggcgugc ugcucaccca gagaacacuu cugagcuugg ucuuagcccu gcuauucccc       60

uccauggcuu cuauggcagc caucggguca ugcaguaagg aguacagggu ucuccuggga      120

caacuucaga aacagacuga ccugaugcag gauacgagcc gguugcucga cccuuauauu      180

cgcauacaag gucuggaugu gccaaagcug cgagaacacu gucgugagag accgggcgcg      240

uuucccuccg aagagacccu caggggguua ggacggcgcg gcuuccugca gacacuuaac      300

gcuacuuugg guugcguacu gcauagacua gccgaccucg aacagaggcu gccuaaagca      360

caggaucuug agcggucugg gcugaauauc gaggacuugg aaaagcucca aauggcccgc      420

ccaaacauuc ugggauuacg aaauaacauc uacuguaugg cucagcugcu cgauaauucg      480

gacaccgcag agcccacaaa agccggcaga ggcgcuucac agccuccaac ccccacuccu      540

gccagcgaug cguuucagag gaaacuugaa gggugccggu uccugcacgg auaucaucgu      600

uuuaugcaca gugugggucg cgucuucucc aaguggggcg agucuccaaa cagaagcagg      660

cggcauuccc cgcaccaagc auugcgaaag ggggugcgca gaacaaggcc cucacggaag      720

ggaaaacgcc uaaugaccag aggccagcug ccuagguga                             759


<210>  4734
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OSM__Homo_sapiens__AAA36388

<400>  4734
augggcgugc ugcugaccca gagaacccug cugagccugg ugcuggcccu gcuguucccc       60

agcauggcca gcauggccgc caucggcagc ugcagcaagg aguacagagu gcugcugggc      120

cagcugcaga agcagaccga ccugaugcag gacaccagca gacugcugga ccccuacauc      180

agaauccagg gccuggacgu gcccaagcug agagagcacu gcagagagag acccggcgcc      240

uuccccagcg aggagacccu gagaggccug ggcagaagag gcuuccugca gacccugaac      300

gccacccugg gcugcgugcu gcacagacug gccgaccugg agcagagacu gcccaaggcc      360

caggaccugg agagaagcgg ccugaacauc gaggaccugg agaagcugca gauggccaga      420

cccaacaucc ugggccugag aaacaacauc uacugcaugg cccagcugcu ggacaacagc      480

gacaccgccg agcccaccaa ggccggcaga ggcgccagcc agccccccac ccccaccccc      540

gccagcgacg ccuuccagag aaagcuggag ggcugcagau uccugcacgg cuaccacaga      600

uucaugcaca gcgugggcag aguguucagc aaguggggcg agagccccaa cagaagcaga      660

agacacagcc cccaccaggc ccugagaaag ggcgugagaa gaaccagacc cagcagaaag      720

ggcaagagac ugaugaccag aggccagcug cccagauga                             759


<210>  4735
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OSM__Homo_sapiens__AAA36388

<400>  4735
augggcgugc ugcucaccca gagaacacug cuuagccugg uccucgcccu gcuuuucccc       60

uccauggcuu cuauggccgc gaucgggagc ugcuccaagg aguaccgggu ucugcucgga      120

caacugcaga aacagacgga ccugaugcag gauaccucuc gccuccugga cccuuauauu      180

agaauccaag gccuugaugu gccgaagcug cgggaacacu gucgcgagag acccggggcu      240

uuuccuagcg aagagacacu ccggggacug ggccgcagag gguuccuuca gacccugaac      300

gccacacucg gaugcgugcu gcaucggcug gccgaccucg aacagcgccu gcccaaagcu      360

caggaucuug agagauccgg ccugaauauu gaggaccucg aaaagcugca aauggcccgg      420

ccuaacaucc uuggccugcg caauaacauu uacuguaugg cucagcuccu ggauaauucu      480

gacaccgccg agcccacaaa agcggggaga ggagccagcc agccuccgac ccccacgccu      540

gcuuccgaug ccuuucagcg gaagcuggaa ggcugccgcu uccuccacgg guaucauaga      600

uuuaugcaca gcgucggacg gguguucucu aaguggggcg agucccccaa cagaagccgc      660

cggcauucuc cucaccaagc ucugagaaaa gggguucgcc ggaccagacc cucccgcaag      720

ggaaaacggc uuaugacaag aggccagcug ccgcgcuga                             759


<210>  4736
<211>  759
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       OSM__Homo_sapiens__AAA36388

<400>  4736
augggcguau uauuaacaca aagaacauua cuaucacuag uacuagcauu auuauucccc       60

ucaauggccu caauggcagc aauaggcuca ugcucaaaag aauacagagu acuauuagga      120

caacuacaaa aacaaacaga cuuaaugcaa gacacaagca gacuucuaga uccauauaua      180

agaauacaag gauuagacgu cccaaaacua agagaacacu gcagagaaag accaggagca      240

uucccaucag aagaaacacu aagaggauua ggacgaagag gauucuuaca aacacuaaac      300

gcaacacuag gauguguauu acauagauua gccgaccuag aacaaagacu accaaaagca      360

caagaccuag aacgaucagg acuaaacaua gaagacuuag aaaaauuaca aauggcaaga      420

ccaaacauac ucggauuacg aaacaauaua uauugcaugg cacaacuauu agacaacuca      480

gauacagcag aacccacaaa agcaggacga ggagcaucac aaccaccaac accaacacca      540

gcaucagacg cauuccaacg aaaacuagaa ggauguagau uccuacaugg auaccacaga      600

uuuaugcacu cagucggaag aguauucuca aaauggggag aaaguccaaa cagaucaaga      660

agacacucac cacaccaagc acucagaaaa ggaguaagaa gaacaagacc aucaagaaaa      720

ggaaaacgac uaaugacaag gggccaacua ccaagauaa                             759


<210>  4737
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40L__Homo_sapiens__P23510

<400>  4737

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  4738
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OX40L__Homo_sapiens__BAA14259

<400>  4738
auggaaaggg uccaaccccu ggaagagaau gugggaaaug cagccaggcc aagauucgag       60

aggaacaagc uauugcuggu ggccucugua auucagggac uggggcugcu ccugugcuuc      120

accuacaucu gccugcacuu cucugcucuu cagguaucac aucgguaucc ucgaauucaa      180

aguaucaaag uacaauuuac cgaauauaag aaggagaaag guuucauccu cacuucccaa      240

aaggaggaug aaaucaugaa ggugcagaac aacucaguca ucaucaacug ugauggguuu      300

uaucucaucu cccugaaggg cuacuucucc caggaaguca acauuagccu ucauuaccag      360

aaggaugagg agccccucuu ccaacugaag aaggucaggu cugucaacuc cuugauggug      420

gccucucuga cuuacaaaga caaagucuac uugaauguga ccacugacaa uaccucccug      480

gaugacuucc augugaaugg cggagaacug auucuuaucc aucaaaaucc uggugaauuc      540

uguguccuuu ga                                                          552


<210>  4739
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OX40L__Homo_sapiens__BAA14259

<400>  4739
auggagcgcg ugcagccccu ggaggagaac gucggcaacg ccgcccggcc gcgcuucgag       60

cggaacaagc uccugcuggu ggcgagcgug auccaggggc ucggccugcu gcucugcuuc      120

accuacaucu gccugcacuu cuccgcccug caggucagcc accgcuaccc ccggauccag      180

uccaucaagg ugcaguucac cgaguacaag aaggagaagg gguucauccu cacgagccag      240

aaggaggacg agaucaugaa ggugcagaac aacuccguca ucaucaacug cgacggcuuc      300

uaccugauca gccugaaggg guacuucucc caggagguga acaucagccu ccacuaccag      360

aaggacgagg agccccuguu ccagcugaag aaggugcgcu ccgucaacag ccucauggug      420

gccucccuga ccuacaagga caagguguac cugaacguca ccaccgacaa cacgagccuc      480

gacgacuucc acgugaacgg cggcgagcug auccugaucc accagaaccc cggggaguuc      540

ugcgugcucu ga                                                          552


<210>  4740
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OX40L__Homo_sapiens__BAA14259

<400>  4740
auggagcgcg uccagccccu cgaggagaac gucggcaacg ccgcccgccc ccgcuucgag       60

cgcaacaagc uccuccucgu cgccuccguc auccagggcc ucggccuccu ccucugcuuc      120

accuacaucu gccuccacuu cuccgcccuc caggucuccc accgcuaccc ccgcauccag      180

uccaucaagg uccaguucac cgaguacaag aaggagaagg gcuucauccu caccucccag      240

aaggaggacg agaucaugaa gguccagaac aacuccguca ucaucaacug cgacggcuuc      300

uaccucaucu cccucaaggg cuacuucucc caggagguca acaucucccu ccacuaccag      360

aaggacgagg agccccucuu ccagcucaag aagguccgcu ccgucaacuc ccucaugguc      420

gccucccuca ccuacaagga caaggucuac cucaacguca ccaccgacaa caccucccuc      480

gacgacuucc acgucaacgg cggcgagcuc auccucaucc accagaaccc cggcgaguuc      540

ugcguccucu ga                                                          552


<210>  4741
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OX40L__Homo_sapiens__BAA14259

<400>  4741
auggagagag ugcagccccu ggaagagaac gucggcaaug ccgcuaggcc ucgguucgaa       60

cgcaacaagc uccuucuggu ugcaagcgug auccaagggu ugggauuacu gcuaugcuuu      120

accuacauuu gucuccacuu cuccgcccug cagguaucuc aucgauaucc acguauacag      180

ucaaucaaag ugcaguuuac agaguacaag aaagaaaagg guuucauucu uacgagucaa      240

aaagaggacg agaucaugaa gguccagaau aacagcguga uuaucaauug cgauggcuuu      300

uaucugauau ccuugaaggg guacuucucu caggaaguua acaucucgcu ccacuaucag      360

aaagacgagg aaccgcuguu ucaacugaag aaagugagau cagucaauag ccucauggug      420

gcgaguuuaa cuuacaagga uaaaguauau cugaacguua ccacagacaa uacuucccuu      480

gaugacuucc augugaacgg aggcgaguug auucugaucc accagaaucc cggugaguuu      540

uguguccuau ga                                                          552


<210>  4742
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OX40L__Homo_sapiens__BAA14259

<400>  4742
auggagagag ugcagccccu ggaggagaac gugggcaacg ccgccagacc cagauucgag       60

agaaacaagc ugcugcuggu ggccagcgug auccagggcc ugggccugcu gcugugcuuc      120

accuacaucu gccugcacuu cagcgcccug caggugagcc acagauaccc cagaauccag      180

agcaucaagg ugcaguucac cgaguacaag aaggagaagg gcuucauccu gaccagccag      240

aaggaggacg agaucaugaa ggugcagaac aacagcguga ucaucaacug cgacggcuuc      300

uaccugauca gccugaaggg cuacuucagc caggagguga acaucagccu gcacuaccag      360

aaggacgagg agccccuguu ccagcugaag aaggugagaa gcgugaacag ccugauggug      420

gccagccuga ccuacaagga caagguguac cugaacguga ccaccgacaa caccagccug      480

gacgacuucc acgugaacgg cggcgagcug auccugaucc accagaaccc cggcgaguuc      540

ugcgugcugu ga                                                          552


<210>  4743
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OX40L__Homo_sapiens__BAA14259

<400>  4743
auggagagag ugcagccccu ggaagagaac gucggcaaug ccgcucggcc ucgcuucgaa       60

agaaacaagc uccugcuugu ugccagcgug auccaagggc ugggacuccu gcuuugcuuu      120

accuacauuu gucugcacuu cuccgcgcuc caggugucuc aucgguaucc gcgcauccag      180

agcauuaaag uccaguuuac agaguacaag aaagaaaagg gcuucauccu gacgucccaa      240

aaagaggacg agauuaugaa ggugcagaau aacucuguua ucaucaauug cgauggguuu      300

uaucugauua gccucaaggg auacuucucc caggaaguga acaucucucu gcacuaucag      360

aaagacgagg aaccccuuuu ucaacugaag aaagucagaa gcguuaauuc ccucauggug      420

gcuagccuga ccuacaagga uaaaguguau cuuaacguca caaccgacaa uacaucucug      480

gaugacuucc augugaacgg cggggagcuc auucugaucc accagaaucc uggagaguuu      540

ugugugcugu ga                                                          552


<210>  4744
<211>  552
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       OX40L__Homo_sapiens__BAA14259

<400>  4744
auggaaagag uacaaccacu agaagaaaac guaggaaacg cagcaagacc aagauucgaa       60

agaaacaaau uacuacuagu agcaucagua auacaaggac uaggacuacu auuaugcuuc      120

acauacauau gccuacacuu cucagcacua caaguauccc acagauaccc aagaauacaa      180

ucaauaaaag uacaauucac cgaauacaaa aaagaaaaag gcuucauacu aacaucccaa      240

aaagaagacg aaauaaugaa aguacaaaac aacucaguaa uaauaaacug cgauggauuc      300

uaccuaauau cacuaaaagg auacuucuca caagaaguaa acauaucccu acacuaccaa      360

aaagacgaag aaccacuauu ccaacuaaaa aaaguaagau caguaaacuc acuaaugguc      420

gcaucacuaa cauacaaaga caaaguauau cuaaacguca caaccgacaa cacaucccua      480

gacgacuucc acguaaacgg aggagaacua auacuaauac accaaaaccc aggagaauuc      540

ugcguacucu aa                                                          552


<210>  4745
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  OX40L__Homo_sapiens__P43489

<400>  4745

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  4746
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  OX40L__Homo_sapiens__AAI05071

<400>  4746
augugcgugg gggcucggcg gcugggccgc gggccgugug cggcucugcu ccuccugggc       60

cuggggcuga gcaccgugac ggggcuccac ugugucgggg acaccuaccc cagcaacgac      120

cggugcugcc acgagugcag gccaggcaac gggaugguga gccgcugcag ccgcucccag      180

aacacggugu gccguccgug cgggccgggc uucuacaacg acguggucag cuccaagccg      240

ugcaagcccu gcacguggug uaaccucaga agugggagug agcggaagca gcugugcacg      300

gccacacagg acacagucug ccgcugccgg gcgggcaccc agccccugga cagcuacaag      360

ccuggaguug acugugcccc cugcccucca gggcacuucu ccccaggcga caaccaggcc      420

ugcaagcccu ggaccaacug caccuuggcu gggaagcaca cccugcagcc ggccagcaau      480

agcucggacg caaucuguga ggacagggac cccccagcca cgcagcccca ggagacccag      540

ggccccccgg ccaggcccau cacuguccag cccacugaag ccuggcccag aaccucacag      600

ggacccucca cccggcccgu ggaggucccc gggggccgug cgguugccgc cauccugggc      660

cugggccugg ugcuggggcu gcugggcccc cuggccaucc ugcuggcccu guaccugcuc      720

cggagggacc agaggcugcc ccccgaugcc cacaagcccc cugggggagg caguuuccgg      780

acccccaucc aagaggagca ggccgacgcc cacuccaccc uggccaagau cuga            834


<210>  4747
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       OX40L__Homo_sapiens__AAI05071

<400>  4747
augugcgugg gcgcccgccg gcuggggcgc ggccccugcg ccgcgcuccu gcugcucggg       60

cugggccuga gcaccgucac cgggcuccac ugcgugggcg acacguaccc cuccaacgac      120

cggugcugcc acgagugccg ccccggcaac gggaugguga gccggugcuc ccgcagccag      180

aacaccgucu gccggcccug cggccccggg uucuacaacg acgugguguc cagcaagccg      240

ugcaagcccu gcaccuggug caaccugcgc uccggcagcg agcggaagca gcugugcacc      300

gccacgcagg acaccgucug ccgcugccgg gccgggaccc agccccucga cuccuacaag      360

cccggcgugg acugcgcccc gugcccgccc ggccacuuca gccccgggga caaccaggcc      420

ugcaagcccu ggaccaacug cacgcuggcg ggcaagcaca cccugcagcc cgccuccaac      480

agcuccgacg ccaucugcga ggaccgcgac ccgcccgcca cccagcccca ggagacccag      540

gggccgcccg cgcggcccau cacggugcag cccaccgagg ccuggccccg caccagccag      600

ggccccucca cccggcccgu cgaggugccg ggcgggcgcg ccguggccgc cauccucggc      660

cuggggcugg uccucggccu gcuggggccc cucgcgaucc ugcuggcccu cuaccugcug      720

cggcgcgacc agcggcuccc gcccgacgcc cacaagccgc ccggcggcgg gagcuuccgc      780

acgcccaucc aggaggagca ggccgacgcc cacuccaccc uggcgaagau cuga            834


<210>  4748
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       OX40L__Homo_sapiens__AAI05071

<400>  4748
augugcgucg gcgcccgccg ccucggccgc ggccccugcg ccgcccuccu ccuccucggc       60

cucggccucu ccaccgucac cggccuccac ugcgucggcg acaccuaccc cuccaacgac      120

cgcugcugcc acgagugccg ccccggcaac ggcauggucu cccgcugcuc ccgcucccag      180

aacaccgucu gccgccccug cggccccggc uucuacaacg acgucgucuc cuccaagccc      240

ugcaagcccu gcaccuggug caaccuccgc uccggcuccg agcgcaagca gcucugcacc      300

gccacccagg acaccgucug ccgcugccgc gccggcaccc agccccucga cuccuacaag      360

cccggcgucg acugcgcccc cugccccccc ggccacuucu cccccggcga caaccaggcc      420

ugcaagcccu ggaccaacug cacccucgcc ggcaagcaca cccuccagcc cgccuccaac      480

uccuccgacg ccaucugcga ggaccgcgac ccccccgcca cccagcccca ggagacccag      540

ggcccccccg cccgccccau caccguccag cccaccgagg ccuggccccg caccucccag      600

ggccccucca cccgccccgu cgaggucccc ggcggccgcg ccgucgccgc cauccucggc      660

cucggccucg uccucggccu ccucggcccc cucgccaucc uccucgcccu cuaccuccuc      720

cgccgcgacc agcgccuccc ccccgacgcc cacaagcccc ccggcggcgg cuccuuccgc      780

acccccaucc aggaggagca ggccgacgcc cacuccaccc ucgccaagau cuga            834


<210>  4749
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       OX40L__Homo_sapiens__AAI05071

<400>  4749
augugcgugg gcgccagaag gcuggggcgg ggacccugug cugcacuccu ucuguugggu       60

uuaggccuga gcaccgucac agggcuacac ugcguuggag acacuuaccc uuccaacgau      120

cgcuguugcc augagugucg accaggcaau gguauggugu cucguugcuc aagaagucag      180

aacacgguau guaggccgug cgggcccgga uucuauaaug acguggucag cuccaagccu      240

uguaaaccau gcaccuggug uaaccuccgg ucuggcucgg aacgcaagca acugugcaca      300

gccacucagg auaccgugug cagauguagg gcgggcacac agccccuuga cucauacaaa      360

ccugggguug auugcgcucc augucccccu ggacacuuua gcccagguga caaucaggcc      420

ugcaagccgu ggaccaacug uacucuggca ggcaaacaua cauugcaacc cgccaguaau      480

uccucugaug cuaucugcga ggaccgggau ccuccagcaa cccagcccca ggaaacgcag      540

gggccuccag cccgccccau uacugugcaa ccgaccgagg cuuggccucg aacaagccag      600

ggacccucca cuagaccagu cgaagugccu ggcgguaggg ccguagcggc aauacucggg      660

cugggacugg uucucggcuu acugggcccc cuugccaucu ugcuggcucu auaucuccug      720

cggcgugacc agcgccuucc acccgaugcc cacaagccuc cagggggagg uucauucaga      780

accccgauuc aggaggagca agcagacgcu cauaguacac uggccaagau cuga            834


<210>  4750
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       OX40L__Homo_sapiens__AAI05071

<400>  4750
augugcgugg gcgccagaag acugggcaga ggccccugcg ccgcccugcu gcugcugggc       60

cugggccuga gcaccgugac cggccugcac ugcgugggcg acaccuaccc cagcaacgac      120

agaugcugcc acgagugcag acccggcaac ggcaugguga gcagaugcag cagaagccag      180

aacaccgugu gcagacccug cggccccggc uucuacaacg acguggugag cagcaagccc      240

ugcaagcccu gcaccuggug caaccugaga agcggcagcg agagaaagca gcugugcacc      300

gccacccagg acaccgugug cagaugcaga gccggcaccc agccccugga cagcuacaag      360

cccggcgugg acugcgcccc cugccccccc ggccacuuca gccccggcga caaccaggcc      420

ugcaagcccu ggaccaacug cacccuggcc ggcaagcaca cccugcagcc cgccagcaac      480

agcagcgacg ccaucugcga ggacagagac ccccccgcca cccagcccca ggagacccag      540

ggcccccccg ccagacccau caccgugcag cccaccgagg ccuggcccag aaccagccag      600

ggccccagca ccagacccgu ggaggugccc ggcggcagag ccguggccgc cauccugggc      660

cugggccugg ugcugggccu gcugggcccc cuggccaucc ugcuggcccu guaccugcug      720

agaagagacc agagacugcc ccccgacgcc cacaagcccc ccggcggcgg cagcuucaga      780

acccccaucc aggaggagca ggccgacgcc cacagcaccc uggccaagau cuga            834


<210>  4751
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       OX40L__Homo_sapiens__AAI05071

<400>  4751
augugcgugg gcgccagacg gcuggggcgc ggacccugug cugcccuccu gcuucugggc       60

cucgggcuga gcaccgucac aggacuucac ugcguuggcg acacguaccc uuccaacgau      120

agauguugcc augagugucg gccggggaau ggaauggugu cucgcugcag cagaucccag      180

aacaccgugu gucggcccug cggcccuggc uucuauaaug acgucguguc uagcaagccc      240

uguaaaccuu gcacauggug uaaccugcgc uccgggucug aaagaaagca acucugcacc      300

gcgacacagg auaccguuug ccggugucgc gcuggaacac agccccugga cagcuacaaa      360

ccuggcgugg auugcgcccc gugucccccu gggcacuuuu cccccggaga caaucaggcc      420

ugcaagccuu ggaccaacug uacgcuggcu ggcaaacaua cccuccaacc cgccagcaau      480

ucuuccgaug cuaucugcga ggacagagau ccgccugcca cacagcccca ggaaacccag      540

gggccucccg cgcggcccau uacaguccaa ccuaccgagg ccuggccgcg cacgagccag      600

ggacccucua caagaccugu ggaaguuccc ggcggccggg cuguggccgc uauccugggg      660

cuuggacugg uccucggccu gcuugggccu cuggccauuc uccuggcgcu guaucuccug      720

cgcagagacc agcggcuucc cccggaugcc cacaagccuc ccggaggcgg guccuucaga      780

accccuaucc aggaggagca agcugacgcc cauagcacac uggcuaagau uuga            834


<210>  4752
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       OX40L__Homo_sapiens__AAI05071

<400>  4752
auguguguug gagcacguag auuaggaaga ggaccaugug cagcauuacu acuacuagga       60

uuaggauuau caacaguaac aggucuacau ugcguuggag auacauaccc aucaaacgac      120

agauguugcc augaauguag accuggaaau ggaaugguau ccagauguag cagaagccaa      180

aacacaguau gcagaccaug cggcccagga uuuuauaacg auguaguauc cucuaaacca      240

uguaaacccu guacauggug uaauuuacga ucaggaagcg aaagaaaaca auuauguaca      300

gcaacacaag auacaguaug cagaugcaga gcaggaacac aaccacuaga uucauacaaa      360

ccagguguag auugcgcucc auguccucca ggacacuucu cacccggaga caaucaagca      420

uguaaaccau ggacaaauug cacauuagca ggaaaacaua cucuacaacc agcaucaaau      480

aguucagaug caauauguga agauagagau ccaccagcaa cccaaccaca agaaacacaa      540

ggaccaccag cacgaccaau aacaguacaa ccgacagaag cauggccaag aacaucacaa      600

ggaccaucaa caagaccagu cgaaguacca ggaggaagag caguagcagc aauauuagga      660

uuaggacuag uauuaggacu acuaggccca cuagcaauau uacuagcacu auaucuauua      720

agaagagacc aaagauuacc accagacgca cacaaaccac caggcggagg cucauucagg      780

acuccaauac aagaagaaca agcagacgca cacucaacau uggcaaaaau auaa            834


<210>  4753
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RANK_ligand__Homo_sapiens__O14788

<400>  4753

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  4754
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4754
augcgccgcg ccagcagaga cuacaccaag uaccugcgug gcucggagga gaugggcggc       60

ggccccggag ccccgcacga gggcccccug cacgccccgc cgccgccugc gccgcaccag      120

cccccugccg ccucccgcuc cauguucgug gcccuccugg ggcuggggcu gggccagguu      180

gucugcagcg ucgcccuguu cuucuauuuc agagcgcaga uggauccuaa uagaauauca      240

gaagauggca cucacugcau uuauagaauu uugagacucc augaaaaugc agauuuucaa      300

gacacaacuc uggagaguca agauacaaaa uuaauaccug auucauguag gagaauuaaa      360

caggccuuuc aaggagcugu gcaaaaggaa uuacaacaua ucguuggauc acagcacauc      420

agagcagaga aagcgauggu ggauggcuca ugguuagauc uggccaagag gagcaagcuu      480

gaagcucagc cuuuugcuca ucucacuauu aaugccaccg acaucccauc ugguucccau      540

aaagugaguc uguccucuug guaccaugau cgggguuggg ccaagaucuc caacaugacu      600

uuuagcaaug gaaaacuaau aguuaaucag gauggcuuuu auuaccugua ugccaacauu      660

ugcuuucgac aucaugaaac uucaggagac cuagcuacag aguaucuuca acuaauggug      720

uacgucacua aaaccagcau caaaauccca aguucucaua cccugaugaa aggaggaagc      780

accaaguauu ggucagggaa uucugaauuc cauuuuuauu ccauaaacgu ugguggauuu      840

uuuaaguuac ggucuggaga ggaaaucagc aucgaggucu ccaaccccuc cuuacuggau      900

ccggaucagg augcaacaua cuuuggggcu uuuaaaguuc gagauauaga uuga            954


<210>  4755
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4755
augcgccggg ccagccgcga cuacaccaag uaccugcggg gcuccgagga gaugggcggc       60

gggcccggcg ccccgcacga ggggccccuc cacgcgcccc cgccgcccgc gccccaccag      120

cccccggccg ccagccgcuc cauguucgug gcccugcugg gccucggccu ggggcagguc      180

gugugcagcg uggcccuguu cuucuacuuc cgggcccaga uggaccccaa ccgcaucucc      240

gaggacggca cccacugcau cuaccggauc cuccgccugc acgagaacgc cgacuuccag      300

gacacgaccc uggagagcca ggacaccaag cucauccccg acuccugccg gcgcaucaag      360

caggccuucc agggggcggu ccagaaggag cugcagcaca ucguggggag ccagcacauc      420

cgggccgaga aggccauggu ggacgggucc uggcuggacc ucgccaagcg cagcaagcug      480

gaggcccagc ccuucgcgca ccugaccauc aacgccacgg acauccccuc cggcagccac      540

aaggucuccc ucagcuccug guaccacgac cggggcuggg ccaagaucag caacaugacc      600

uucuccaacg ggaagcugau cgugaaccag gacggcuucu acuaccugua cgccaacauc      660

ugcuuccgcc accacgagac cagcggggac cucgccaccg aguaccugca gcugauggug      720

uacgucacga agaccuccau caagaucccc agcagccaca cccucaugaa gggcggcucc      780

accaaguacu ggagcgggaa cuccgaguuc cacuucuaca gcaucaacgu gggcggguuc      840

uucaagcugc gguccggcga ggagaucagc aucgaggugu ccaaccccag ccugcucgac      900

cccgaccagg acgcgacgua cuucggggcc uucaaggucc gcgacaucga cuga            954


<210>  4756
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4756
augcgccgcg ccucccgcga cuacaccaag uaccuccgcg gcuccgagga gaugggcggc       60

ggccccggcg ccccccacga gggcccccuc cacgcccccc ccccccccgc cccccaccag      120

ccccccgccg ccucccgcuc cauguucguc gcccuccucg gccucggccu cggccagguc      180

gucugcuccg ucgcccucuu cuucuacuuc cgcgcccaga uggaccccaa ccgcaucucc      240

gaggacggca cccacugcau cuaccgcauc cuccgccucc acgagaacgc cgacuuccag      300

gacaccaccc ucgaguccca ggacaccaag cucauccccg acuccugccg ccgcaucaag      360

caggccuucc agggcgccgu ccagaaggag cuccagcaca ucgucggcuc ccagcacauc      420

cgcgccgaga aggccauggu cgacggcucc uggcucgacc ucgccaagcg cuccaagcuc      480

gaggcccagc ccuucgccca ccucaccauc aacgccaccg acauccccuc cggcucccac      540

aaggucuccc ucuccuccug guaccacgac cgcggcuggg ccaagaucuc caacaugacc      600

uucuccaacg gcaagcucau cgucaaccag gacggcuucu acuaccucua cgccaacauc      660

ugcuuccgcc accacgagac cuccggcgac cucgccaccg aguaccucca gcucaugguc      720

uacgucacca agaccuccau caagaucccc uccucccaca cccucaugaa gggcggcucc      780

accaaguacu gguccggcaa cuccgaguuc cacuucuacu ccaucaacgu cggcggcuuc      840

uucaagcucc gcuccggcga ggagaucucc aucgaggucu ccaaccccuc ccuccucgac      900

cccgaccagg acgccaccua cuucggcgcc uucaaggucc gcgacaucga cuga            954


<210>  4757
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4757
augagaaggg ccagccggga cuacaccaag uaucugcgcg gcuccgagga aaugggaggg       60

ggucccggcg cuccucacga ggggccacuc caugcaccgc ccccuccagc gccccaccag      120

ccuccagccg cuucucgauc aauguucgug gcccuucugg gauugggcuu aggucaaguc      180

guuugcagug uggcacuguu uuucuacuuu cgugcccaga uggaucccaa cagaaucagc      240

gaagacggga cacauuguau uuauaggaua cuacggcucc acgagaaugc ugauuuccag      300

gacacuacgc uggaauccca ggauaccaaa cuuaucccug acucuugccg cagaauuaag      360

caagcauuuc agggagccgu acagaaagag cugcagcaua ucgugggcuc gcaacacauu      420

agggcugaga aggccauggu cgauggcuca ugguuggacc ucgcgaaacg gagcaagcug      480

gaagcacagc cauucgccca ccugacaauc aacgcuacug auauaccgag ugggucccau      540

aaggugucuc ucagcuccug guaccacgac cgcggauggg ccaaaaucuc aaauaugacc      600

uuuaguaacg guaaguuaau uguuaaucag gauggcuucu auuaccugua ugcaaacauc      660

uguuuucgac aucacgagac aagcggggac cuugcuaccg aauacuugca gcugauggug      720

uacgucacua aaacaucuau uaagaucccc uccucacaca cccuaaugaa aggaggcagc      780

acgaaguauu ggagugguaa uucugaguuc cauuuuuacu ccauaaacgu agggggauuc      840

uuuaagcuca gaagcggcga ggaaauuucg aucgaggugu cuaauccuuc ccugcuugau      900

ccagaccaag acgccacuua uuucggcgcg uucaaaguua gggauauuga cuga            954


<210>  4758
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4758
augagaagag ccagcagaga cuacaccaag uaccugagag gcagcgagga gaugggcggc       60

ggccccggcg ccccccacga gggcccccug cacgcccccc ccccccccgc cccccaccag      120

ccccccgccg ccagcagaag cauguucgug gcccugcugg gccugggccu gggccaggug      180

gugugcagcg uggcccuguu cuucuacuuc agagcccaga uggaccccaa cagaaucagc      240

gaggacggca cccacugcau cuacagaauc cugagacugc acgagaacgc cgacuuccag      300

gacaccaccc uggagagcca ggacaccaag cugauccccg acagcugcag aagaaucaag      360

caggccuucc agggcgccgu gcagaaggag cugcagcaca ucgugggcag ccagcacauc      420

agagccgaga aggccauggu ggacggcagc uggcuggacc uggccaagag aagcaagcug      480

gaggcccagc ccuucgccca ccugaccauc aacgccaccg acauccccag cggcagccac      540

aaggugagcc ugagcagcug guaccacgac agaggcuggg ccaagaucag caacaugacc      600

uucagcaacg gcaagcugau cgugaaccag gacggcuucu acuaccugua cgccaacauc      660

ugcuucagac accacgagac cagcggcgac cuggccaccg aguaccugca gcugauggug      720

uacgugacca agaccagcau caagaucccc agcagccaca cccugaugaa gggcggcagc      780

accaaguacu ggagcggcaa cagcgaguuc cacuucuaca gcaucaacgu gggcggcuuc      840

uucaagcuga gaagcggcga ggagaucagc aucgagguga gcaaccccag ccugcuggac      900

cccgaccagg acgccaccua cuucggcgcc uucaagguga gagacaucga cuga            954


<210>  4759
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4759
augagacggg ccagccgcga cuacaccaag uaucugagag gcuccgagga aaugggaggg       60

ggccccgggg cuccucacga gggaccgcuc caugcgcccc cucccccugc uccccaccag      120

ccuccggccg ccucucggag cauguucgug gcccugcuug gccuggggcu cggacaaguc      180

guuugcuccg uggcucuguu uuucuacuuu cgcgcccaga uggaucccaa cagaaucucu      240

gaagacggca cacauuguau uuaucggauc cuucgccugc acgagaaugc ugauuuccag      300

gacacgaccc ucgaaagcca ggauacaaaa cugauuccug acuccugcag acggaucaag      360

caagccuuuc agggcgcggu gcagaaagag cugcagcaua uugucggguc ucaacacauc      420

cgcgccgaga aggcuauggu ggauggaagc uggcucgacc uggccaaaag auccaaacuu      480

gaagcucagc ccuucgccca ccugaccauc aacgcgacag auauuccuag cggcucucau      540

aagguuuccc ucagcucuug guaccacgac cggggguggg ccaagaucuc caauaugacc      600

uuuagcaacg gaaagcugau ugugaaucag gauggcuucu auuaccuuua ugcuaacauc      660

uguuuucgcc aucacgagac aucuggggac cuggccaccg aauaccucca gcugaugguc      720

uacgugacga aaaccuccau uaagaucccc agcucccaca cacugaugaa aggaggcucu      780

accaaguauu ggagcggcaa uuccgaguuc cauuuuuaca gcauuaacgu ugggggauuc      840

uuuaagcuca gaucuggcga ggaaaucucc aucgagguga gcaauccguc ucugcuugau      900

ccugaccaag acgcuacaua uuucggggcc uucaaagucc gggauauuga cuga            954


<210>  4760
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       RANK_ligand__Homo_sapiens__CCDS9384.1

<400>  4760
augagaagag caagcagaga cuacacaaaa uacuuaagag gaagcgaaga aaugggagga       60

gguccaggag caccacauga aggaccauua caugcgccuc caccaccagc accacaccaa      120

ccaccagcag caucaagauc aauguuugua gcacuauuag gacuaggacu uggacaagua      180

gucuguucag uagcacuauu uuucuacuuc agagcacaaa uggacccaaa cagaauauca      240

gaagacggaa cacacugcau auaccgaaua uuaagacuac acgaaaacgc agacuuucaa      300

gauacaacau uagaaucaca agacacaaaa cuaauaccug acaguugcag aagaauaaaa      360

caagcauucc aaggagcagu acaaaaagaa uuacaacaua uaguaggauc acaacacaua      420

agagcagaaa aagcaauggu agacggauca ugguuagacc uagccaaaag aucaaaacua      480

gaagcacaac cauucgccca cuuaacaaua aacgcaacag acaucccaag uggaagucac      540

aaaguaucac uaucaucaug guaccacgac agagguuggg caaaaauaag uaauaugaca      600

uucucaaacg gaaaauuaau aguaaaccaa gacggauuuu acuacuuaua ugcaaacaua      660

ugcuucagac aucacgaaac cucaggcgac cuagcaacag aauaccuaca auuaauggua      720

uacguaacaa aaacaucaau aaaaauacca aguucacaua cacuaaugaa aggcggauca      780

accaaauacu ggucugguaa uucagaauuc cacuuuuacu cuaucaacgu aggaggauuu      840

uucaaacuac gaucagggga agaaauaagc auagaaguau caaauccuuc acuauuagac      900

cccgaccaag augcuacaua cuucggcgca uucaaaguaa gagacauaga cuaa            954


<210>  4761
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Stem_Cell_Factor__Homo_sapiens__P21583-2

<400>  4761

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Gly Lys Ala 
                165                 170                 175     


Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu 
            180                 185                 190         


Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr 
        195                 200                 205             


Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln 
    210                 215                 220                 


Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg 
225                 230                 235                 240 


Glu Phe Gln Glu Val 
                245 


<210>  4762
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4762
augaagaaga cacaaacuug gauucucacu ugcauuuauc uucagcugcu ccuauuuaau       60

ccucucguca aaacugaagg gaucugcagg aaucguguga cuaauaaugu aaaagacguc      120

acuaaauugg uggcaaaucu uccaaaagac uacaugauaa cccucaaaua uguccccggg      180

auggauguuu ugccaaguca uuguuggaua agcgagaugg uaguacaauu gucagacagc      240

uugacugauc uucuggacaa guuuucaaau auuucugaag gcuugaguaa uuauuccauc      300

auagacaaac uugugaauau aguggaugac cuuguggagu gcgugaaaga aaacucaucu      360

aaggaucuaa aaaaaucauu caagagccca gaacccaggc ucuuuacucc ugaagaauuc      420

uuuagaauuu uuaauagauc cauugaugcc uucaaggacu uuguaguggc aucugaaacu      480

agugauugug ugguuucuuc aacauuaagu ccugagaaag ggaaggccaa aaaucccccu      540

ggagacucca gccuacacug ggcagccaug gcauugccag cauuguuuuc ucuuauaauu      600

ggcuuugcuu uuggagccuu auacuggaag aagagacagc caagucuuac aagggcaguu      660

gaaaauauac aaauuaauga agaggauaau gagauaagua uguugcaaga gaaagagaga      720

gaguuucaag aaguguaa                                                    738


<210>  4763
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4763
augaagaaga cccagaccug gauccugacg ugcaucuacc uccagcugcu ccucuucaac       60

ccccugguga agaccgaggg caucugccgc aaccggguca ccaacaacgu gaaggacgug      120

accaagcugg ucgccaaccu cccgaaggac uacaugauca cgcugaagua cgugcccggg      180

auggacgugc ugcccagcca cugcuggauc uccgagaugg ucgugcagcu cagcgacucc      240

cugaccgacc ugcucgacaa guucagcaac aucuccgagg gccugagcaa cuacuccauc      300

aucgacaagc uggugaacau cgucgacgac cucguggagu gcgugaagga gaacagcucc      360

aaggaccuga agaaguccuu caagagcccc gagccgcgcc uguucacccc cgaggaguuc      420

uuccggaucu ucaaccgcag caucgacgcc uucaaggacu ucgucguggc guccgagacc      480

agcgacugcg uggucuccag cacgcucucc cccgagaagg ggaaggccaa gaacccgccc      540

ggcgacagcu cccugcacug ggccgccaug gcccugcccg cgcuguucag ccugaucauc      600

ggguucgccu ucggcgcccu guacuggaag aagcggcagc ccagccucac ccgcgccgug      660

gagaacaucc agaucaacga ggaggacaac gagaucucca ugcugcagga gaaggagcgg      720

gaguuccagg agguguga                                                    738


<210>  4764
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4764
augaagaaga cccagaccug gauccucacc ugcaucuacc uccagcuccu ccucuucaac       60

ccccucguca agaccgaggg caucugccgc aaccgcguca ccaacaacgu caaggacguc      120

accaagcucg ucgccaaccu ccccaaggac uacaugauca cccucaagua cguccccggc      180

auggacgucc uccccuccca cugcuggauc uccgagaugg ucguccagcu cuccgacucc      240

cucaccgacc uccucgacaa guucuccaac aucuccgagg gccucuccaa cuacuccauc      300

aucgacaagc ucgucaacau cgucgacgac cucgucgagu gcgucaagga gaacuccucc      360

aaggaccuca agaaguccuu caaguccccc gagccccgcc ucuucacccc cgaggaguuc      420

uuccgcaucu ucaaccgcuc caucgacgcc uucaaggacu ucgucgucgc cuccgagacc      480

uccgacugcg ucgucuccuc cacccucucc cccgagaagg gcaaggccaa gaaccccccc      540

ggcgacuccu cccuccacug ggccgccaug gcccuccccg cccucuucuc ccucaucauc      600

ggcuucgccu ucggcgcccu cuacuggaag aagcgccagc ccucccucac ccgcgccguc      660

gagaacaucc agaucaacga ggaggacaac gagaucucca ugcuccagga gaaggagcgc      720

gaguuccagg aggucuga                                                    738


<210>  4765
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4765
augaagaaaa cccagacaug gauccugacu ugcauuuacc uccaacuucu guuguucaac       60

cccuuaguga agacggaggg cauauguaga aauaggguca ccaacaaugu uaaagacgug      120

acaaagcugg uagccaaccu accuaaagau uauaugauca cucucaagua cgugccaggg      180

auggacgucc ugccgagcca cugcuggauu uccgaaaugg ugguucagcu uucugauuca      240

cugaccgacu ugcucgauaa guuuaguaau aucagcgagg gacuguccaa cuauucuauu      300

aucgacaaac uggugaauau agucgaugac cucguggaau guguaaagga gaacucguca      360

aaagauuuaa agaaaaguuu caagagcccc gaaccucggc uguuuacacc agaggaguuc      420

uuucgcaucu ucaaucgauc cauugacgcu uuuaaggauu ucguuguggc aucugaaacc      480

agcgacugcg ucguguccuc aacucuuagu cccgagaaag guaaggccaa aaacccucca      540

ggcgauagcu cuuugcauug ggcggcuaug gcccugcccg cacuauuuuc ccucaucauu      600

ggguucgccu uuggagcucu guacuggaag aaacgucagc cuucacuuac aagagcagug      660

gaaaauaucc agauaaacga ggaggacaau gaaauuagca ugcugcaaga gaaggaaagg      720

gaguuccagg aagucuga                                                    738


<210>  4766
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4766
augaagaaga cccagaccug gauccugacc ugcaucuacc ugcagcugcu gcuguucaac       60

ccccugguga agaccgaggg caucugcaga aacagaguga ccaacaacgu gaaggacgug      120

accaagcugg uggccaaccu gcccaaggac uacaugauca cccugaagua cgugcccggc      180

auggacgugc ugcccagcca cugcuggauc agcgagaugg uggugcagcu gagcgacagc      240

cugaccgacc ugcuggacaa guucagcaac aucagcgagg gccugagcaa cuacagcauc      300

aucgacaagc uggugaacau cguggacgac cugguggagu gcgugaagga gaacagcagc      360

aaggaccuga agaagagcuu caagagcccc gagcccagac uguucacccc cgaggaguuc      420

uucagaaucu ucaacagaag caucgacgcc uucaaggacu ucgugguggc cagcgagacc      480

agcgacugcg uggugagcag cacccugagc cccgagaagg gcaaggccaa gaaccccccc      540

ggcgacagca gccugcacug ggccgccaug gcccugcccg cccuguucag ccugaucauc      600

ggcuucgccu ucggcgcccu guacuggaag aagagacagc ccagccugac cagagccgug      660

gagaacaucc agaucaacga ggaggacaac gagaucagca ugcugcagga gaaggagaga      720

gaguuccagg agguguga                                                    738


<210>  4767
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4767
augaagaaaa cccagacaug gauccugacg ugcauuuacc uccaacugcu ucuguucaac       60

ccccucguga agaccgaggg caucuguaga aaucggguca caaacaaugu uaaagacgug      120

accaagcugg uggccaaccu uccuaaagau uauaugauua cacugaagua cgucccgggg      180

auggacgugc uccccagcca cugcuggauc uccgaaaugg uugugcagcu gucugauagc      240

cugaccgacc uccuggauaa guuuuccaau auuucugagg gacuuagcaa cuauuccauc      300

aucgacaaac uggucaauau uguggaugac cucguugaau gugugaagga gaacucuagc      360

aaagaucuga agaaauccuu caagagcccu gaaccccgcc uuuuuacacc ugaggaguuc      420

uuuagaaucu ucaaucgguc uauugacgcu uuuaaggauu ucgucguggc cuccgaaacc      480

agcgacugcg uggucucuuc cacgcugagc cccgagaaag gcaaggcgaa aaacccuccg      540

ggggauucuu cccuccauug ggcugccaug gcccugcccg cucuguuuag ccucaucauu      600

ggauucgccu uuggcgcucu guacuggaag aaacgccagc cuucccuuac cagagccguu      660

gaaaauaucc agauuaacga ggaggacaau gaaaucucua ugcugcaaga gaaggaacgg      720

gaguuccagg aaguguga                                                    738


<210>  4768
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31867.1

<400>  4768
augaaaaaaa cacaaaccug gauacuaaca ugcauauauc uacaauuauu auuauucaac       60

ccacuaguaa aaacagaagg aauaugccga aacagaguca caaacaacgu aaaagacgua      120

acaaaacuag uagcaaacuu accaaaagac uacaugauaa cacuaaaaua cguaccagga      180

auggacguac uaccaucaca cugcuggaua ucagaaaugg uaguacaacu aucagauucc      240

uuaacagacc uauuagacaa auucucaaac auaucagaag gauuaucaaa cuauucaaua      300

auagacaaac uaguaaacau aguagacgac cuaguagaau gcguaaaaga aaacucauca      360

aaagacuuaa aaaaaucauu caaaucacca gaaccaagac uauuuacacc agaagaauuc      420

uucagaauau ucaacagauc aauagacgca uuuaaagacu ucguaguagc uucagaaaca      480

ucagacugcg uaguaucauc aacacuauca ccagaaaaag gcaaagcaaa aaacccacca      540

ggagacucau cauuacacug ggcagcaaug gcacuacccg cacuauucuc acuaauaaua      600

ggauucgccu uuggugcauu auacuggaaa aaaagacaac caucacucac aagagcagua      660

gaaaacauac aaaucaacga agaagacaac gaaauaucaa ugcuacaaga aaaagaacga      720

gaauuccaag aaguauaa                                                    738


<210>  4769
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Stem_Cell_Factor__Homo_sapiens__P21583

<400>  4769

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  4770
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4770
augaagaaga cacaaacuug gauucucacu ugcauuuauc uucagcugcu ccuauuuaau       60

ccucucguca aaacugaagg gaucugcagg aaucguguga cuaauaaugu aaaagacguc      120

acuaaauugg uggcaaaucu uccaaaagac uacaugauaa cccucaaaua uguccccggg      180

auggauguuu ugccaaguca uuguuggaua agcgagaugg uaguacaauu gucagacagc      240

uugacugauc uucuggacaa guuuucaaau auuucugaag gcuugaguaa uuauuccauc      300

auagacaaac uugugaauau aguggaugac cuuguggagu gcgugaaaga aaacucaucu      360

aaggaucuaa aaaaaucauu caagagccca gaacccaggc ucuuuacucc ugaagaauuc      420

uuuagaauuu uuaauagauc cauugaugcc uucaaggacu uuguaguggc aucugaaacu      480

agugauugug ugguuucuuc aacauuaagu ccugagaaag auuccagagu cagugucaca      540

aaaccauuua uguuaccccc uguugcagcc agcucccuua ggaaugacag caguagcagu      600

aauaggaagg ccaaaaaucc cccuggagac uccagccuac acugggcagc cauggcauug      660

ccagcauugu uuucucuuau aauuggcuuu gcuuuuggag ccuuauacug gaagaagaga      720

cagccaaguc uuacaagggc aguugaaaau auacaaauua augaagagga uaaugagaua      780

aguauguugc aagagaaaga gagagaguuu caagaagugu aa                         822


<210>  4771
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4771
augaagaaga cccagaccug gauccugacg ugcaucuacc uccagcugcu ccuguucaac       60

ccccugguga agaccgaggg caucugccgc aaccggguca ccaacaacgu gaaggacgug      120

accaagcugg ucgccaaccu cccgaaggac uacaugauca cgcugaagua cgugcccggg      180

auggacgugc ugcccagcca cugcuggauc uccgagaugg ucgugcagcu cagcgacucc      240

cugaccgacc ugcucgacaa guucagcaac aucuccgagg gccugagcaa cuacuccauc      300

aucgacaagc uggugaacau cgucgacgac cucguggagu gcgugaagga gaacagcucc      360

aaggaccuga agaaguccuu caagagcccc gagccgcgcc uguucacccc cgaggaguuc      420

uuccggaucu ucaaccgcag caucgacgcc uucaaggacu ucgucguggc guccgagacc      480

agcgacugcg uggucuccag cacgcucucc cccgagaagg acagccgggu guccgugacc      540

aagcccuuca ugcugccgcc cgucgccgcc agcagccugc gcaacgacuc cagcuccagc      600

aaccggaagg ccaagaaccc gcccggggac uccagccucc acugggccgc gauggcccug      660

cccgcccugu ucucccucau caucggcuuc gccuucgggg cgcuguacug gaagaagcgc      720

cagcccagcc ugacccgggc cguggagaac auccagauca acgaggagga caacgagauc      780

uccaugcucc aggagaagga gcgcgaguuc caggaggugu ga                         822


<210>  4772
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4772
augaagaaga cccagaccug gauccucacc ugcaucuacc uccagcuccu ccucuucaac       60

ccccucguca agaccgaggg caucugccgc aaccgcguca ccaacaacgu caaggacguc      120

accaagcucg ucgccaaccu ccccaaggac uacaugauca cccucaagua cguccccggc      180

auggacgucc uccccuccca cugcuggauc uccgagaugg ucguccagcu cuccgacucc      240

cucaccgacc uccucgacaa guucuccaac aucuccgagg gccucuccaa cuacuccauc      300

aucgacaagc ucgucaacau cgucgacgac cucgucgagu gcgucaagga gaacuccucc      360

aaggaccuca agaaguccuu caaguccccc gagccccgcc ucuucacccc cgaggaguuc      420

uuccgcaucu ucaaccgcuc caucgacgcc uucaaggacu ucgucgucgc cuccgagacc      480

uccgacugcg ucgucuccuc cacccucucc cccgagaagg acucccgcgu cuccgucacc      540

aagcccuuca ugcucccccc cgucgccgcc uccucccucc gcaacgacuc cuccuccucc      600

aaccgcaagg ccaagaaccc ccccggcgac uccucccucc acugggccgc cauggcccuc      660

cccgcccucu ucucccucau caucggcuuc gccuucggcg cccucuacug gaagaagcgc      720

cagcccuccc ucacccgcgc cgucgagaac auccagauca acgaggagga caacgagauc      780

uccaugcucc aggagaagga gcgcgaguuc caggaggucu ga                         822


<210>  4773
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4773
augaagaaaa cccagacaug gauccugacu ugcauuuacc uccaacuucu guuguucaac       60

cccuuaguga agacggaggg cauauguaga aauaggguca ccaacaaugu uaaagacgug      120

acaaagcugg uagccaaccu accuaaagau uauaugauca cucucaagua cgugccaggg      180

auggacgucc ugccgagcca cugcuggauu uccgaaaugg ugguucagcu uucugauuca      240

cugaccgacu ugcucgauaa guuuaguaau aucagcgagg gacuguccaa cuauucuauu      300

aucgacaaac uggugaauau agucgaugac cucguggaau guguaaagga gaacucguca      360

aaagauuuaa agaaaaguuu caagagcccc gaaccucggc uguuuacacc agaggaguuc      420

uuucgcaucu ucaaucgauc cauugacgcu uuuaaggauu ucguuguggc aucugaaacc      480

agcgacugcg ucguguccuc aacucuuagu cccgagaaag auagccgugu gucugucaca      540

aagccuuuua uguugccacc cguugccgcg uccucacuga gaaacgacag caguucuucc      600

aauaggaaag cuaagaaccc uccaggugac agcucgcuac auugggccgc aauggcccuc      660

ccggcucugu ucucucuuau cauuggcuuu gcauucgggg cccuguacug gaaaaagcgg      720

cagcccuccu ugacccgcgc uguggaaaau auccagauaa acgaggagga uaaugaaauu      780

ucaaugcucc aagagaaaga aagagaguuu caggaaguau ga                         822


<210>  4774
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4774
augaagaaga cccagaccug gauccugacc ugcaucuacc ugcagcugcu gcuguucaac       60

ccccugguga agaccgaggg caucugcaga aacagaguga ccaacaacgu gaaggacgug      120

accaagcugg uggccaaccu gcccaaggac uacaugauca cccugaagua cgugcccggc      180

auggacgugc ugcccagcca cugcuggauc agcgagaugg uggugcagcu gagcgacagc      240

cugaccgacc ugcuggacaa guucagcaac aucagcgagg gccugagcaa cuacagcauc      300

aucgacaagc uggugaacau cguggacgac cugguggagu gcgugaagga gaacagcagc      360

aaggaccuga agaagagcuu caagagcccc gagcccagac uguucacccc cgaggaguuc      420

uucagaaucu ucaacagaag caucgacgcc uucaaggacu ucgugguggc cagcgagacc      480

agcgacugcg uggugagcag cacccugagc cccgagaagg acagcagagu gagcgugacc      540

aagcccuuca ugcugccccc cguggccgcc agcagccuga gaaacgacag cagcagcagc      600

aacagaaagg ccaagaaccc ccccggcgac agcagccugc acugggccgc cauggcccug      660

cccgcccugu ucagccugau caucggcuuc gccuucggcg cccuguacug gaagaagaga      720

cagcccagcc ugaccagagc cguggagaac auccagauca acgaggagga caacgagauc      780

agcaugcugc aggagaagga gagagaguuc caggaggugu ga                         822


<210>  4775
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4775
augaagaaaa cccagacaug gauccugacg ugcauuuacc uccaacugcu ucuguucaac       60

ccccucguga agaccgaggg caucuguaga aaucggguca caaacaaugu uaaagacgug      120

accaagcugg uggccaaccu uccuaaagau uauaugauua cacugaagua cgucccgggg      180

auggacgugc uccccagcca cugcuggauc uccgaaaugg uugugcagcu gucugauagc      240

cugaccgacc uccuggauaa guuuuccaau auuucugagg gacuuagcaa cuauuccauc      300

aucgacaaac uggucaauau uguggaugac cucguugaau gugugaagga gaacucuagc      360

aaagaucuga agaaauccuu caagagcccu gaaccccgcc uuuuuacacc ugaggaguuc      420

uuuagaaucu ucaaucgguc uauugacgcu uuuaaggauu ucgucguggc cuccgaaacc      480

agcgacugcg uggucucuuc cacgcugagc cccgagaaag auucucgcgu uuccgugacc      540

aagccuuuua ugcucccgcc cguggcggcu agcucccuga gaaacgacuc uagcuccagc      600

aaucggaaag ccaagaaccc ucccggcgac ucuucccugc auugggccgc uauggcccuc      660

ccugcucugu ucagccuuau cauuggguuu gccuucggag cgcuguacug gaaaaagcgc      720

cagcccucuc ucacaagagc cgucgaaaau auccagauua acgaggagga uaaugaaauc      780

agcaugcugc aagagaaaga acgggaguuu caggaagugu ga                         822


<210>  4776
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Stem_Cell_Factor__Homo_sapiens__CCDS31868.1

<400>  4776
augaaaaaaa cacaaacaug gauccucaca ugcauauacc uacaacuacu acuauucaac       60

ccauuaguaa aaacagaagg aaucugcaga aacagaguaa caaacaacgu caaagacgua      120

acaaaacuag uagcaaaucu acccaaagac uacaugauaa cacuaaaaua cguaccagga      180

auggacguac ucccauccca cugcuggaua uccgaaaugg uaguacaacu aucagauuca      240

cuaacagacc uauuagacaa auucucaaac auaucagaag gauuaucaaa cuacucuaua      300

auagacaaau uaguaaacau aguagacgac cuagucgaau guguuaaaga aaacuccuca      360

aaagaccuaa aaaaaagcuu caaaucacca gaaccucgac uauucacacc cgaagaauuc      420

uucagaauau ucaacagauc aauagacgca uucaaagacu ucguuguagc aucagaaaca      480

ucugacugug uaguaagcuc aacacuauca ccagaaaaag acucacgagu auccgucaca      540

aaaccauuua ugcuaccacc aguagcugca ucaucauuaa gaaacgacuc aucaucaucc      600

aacagaaaag caaaaaaccc accaggagac ucaucacuac acugggcagc aauggcacua      660

ccagcauuau uuucauuaau aauaggauuc gcauucggag cacuauacug gaaaaaacgu      720

caaccaucau uaacacgagc aguagaaaac auacaaauaa acgaagaaga uaacgaaaua      780

ucaaugcuac aagaaaaaga aagagaauuu caagaaguuu aa                         822


<210>  4777
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFbeta1__Homo_sapiens__A0A024R0P8

<400>  4777

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  4778
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFbeta1__Homo_sapiens__EAW57033

<400>  4778
augccgcccu ccgggcugcg gcugcugcug cugcugcuac cgcugcugug gcuacuggug       60

cugacgccug gccggccggc cgcgggacua uccaccugca agacuaucga cauggagcug      120

gugaagcgga agcgcaucga ggccauccgc ggccagaucc uguccaagcu gcggcucgcc      180

agccccccga gccaggggga ggugccgccc ggcccgcugc ccgaggccgu gcucgcccug      240

uacaacagca cccgcgaccg gguggccggg gagagugcag aaccggagcc cgagccugag      300

gccgacuacu acgccaagga ggucacccgc gugcuaaugg uggaaaccca caacgaaauc      360

uaugacaagu ucaagcagag uacacacagc auauauaugu ucuucaacac aucagagcuc      420

cgagaagcgg uaccugaacc cguguugcuc ucccgggcag agcugcgucu gcugaggcuc      480

aaguuaaaag uggagcagca cguggagcug uaccagaaau acagcaacaa uuccuggcga      540

uaccucagca accggcugcu ggcacccagc gacucgccag agugguuauc uuuugauguc      600

accggaguug ugcggcagug guugagccgu ggaggggaaa uugagggcuu ucgccuuagc      660

gcccacugcu ccugugacag cagggauaac acacugcaag uggacaucaa cggguucacu      720

accggccgcc gaggugaccu ggccaccauu cauggcauga accggccuuu ccugcuucuc      780

auggccaccc cgcuggagag ggcccagcau cugcaaagcu cccggcaccg ccgagcccug      840

gacaccaacu auugcuucag cuccacggag aagaacugcu gcgugcggca gcuguacauu      900

gacuuccgca aggaccucgg cuggaagugg auccacgagc ccaagggcua ccaugccaac      960

uucugccucg ggcccugccc cuacauuugg agccuggaca cgcaguacag caagguccug     1020

gcccuguaca accagcauaa cccgggcgcc ucggcggcgc cgugcugcgu gccgcaggcg     1080

cuggagccgc ugcccaucgu guacuacgug ggccgcaagc ccaaggugga gcagcugucc     1140

aacaugaucg ugcgcuccug caagugcagc uga                                  1173


<210>  4779
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4779
augcccccga gcggccugcg ccuccugcug cuccugcugc cccuccugug gcugcucgug       60

cugacccccg ggcggcccgc cgccggccug uccacgugca agaccaucga cauggagcuc      120

gucaagcgca agcggaucga ggcgauccgc gggcagaucc ugagcaagcu gcggcucgcc      180

uccccgccca gccagggcga ggugccgccc gggccccugc ccgaggccgu gcuggcccuc      240

uacaacucca cccgcgaccg ggucgccggc gagagcgcgg agcccgagcc cgagccggag      300

gccgacuacu acgccaagga ggugacccgc gugcugaugg ucgagaccca caacgagauc      360

uacgacaagu ucaagcaguc cacgcacagc aucuacaugu ucuucaacac cuccgagcug      420

cgggaggccg ugcccgagcc cgugcuccug agccgcgcgg agcugcggcu ccugcgccug      480

aagcucaagg ucgagcagca cguggagcug uaccagaagu acuccaacaa cagcuggcgg      540

uaccugucca accgccuccu ggcccccagc gacuccccgg aguggcugag cuucgacgug      600

accggcgucg ugcggcagug gcucucccgc gggggcgaga ucgagggguu ccggcugagc      660

gcccacugcu ccugcgacag ccgcgacaac acccuccagg uggacaucaa cggcuucacg      720

accgggcggc gcggcgaccu ggccaccauc cacggcauga accggcccuu ccugcugcuc      780

auggccacgc cccuggagcg cgcgcagcac cuccagagcu cccgccaccg gcgcgcccug      840

gacaccaacu acugcuucag cuccaccgag aagaacugcu gcguccggca gcuguacauc      900

gacuuccgca aggaccuggg guggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccucg ggccgugccc cuacaucugg agccuggaca cccaguacuc caaggugcug     1020

gcccucuaca accagcacaa ccccggcgcc agcgcggccc ccugcugcgu gccgcaggcc     1080

cuggagcccc ugcccaucgu cuacuacgug ggccggaagc ccaaggugga gcagcugucc     1140

aacaugaucg uccgcagcug caagugcucc uga                                  1173


<210>  4780
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4780
augccccccu ccggccuccg ccuccuccuc cuccuccucc cccuccucug gcuccucguc       60

cucacccccg gccgccccgc cgccggccuc uccaccugca agaccaucga cauggagcuc      120

gucaagcgca agcgcaucga ggccauccgc ggccagaucc ucuccaagcu ccgccucgcc      180

uccccccccu cccagggcga gguccccccc ggcccccucc ccgaggccgu ccucgcccuc      240

uacaacucca cccgcgaccg cgucgccggc gaguccgccg agcccgagcc cgagcccgag      300

gccgacuacu acgccaagga ggucacccgc guccucaugg ucgagaccca caacgagauc      360

uacgacaagu ucaagcaguc cacccacucc aucuacaugu ucuucaacac cuccgagcuc      420

cgcgaggccg uccccgagcc cguccuccuc ucccgcgccg agcuccgccu ccuccgccuc      480

aagcucaagg ucgagcagca cgucgagcuc uaccagaagu acuccaacaa cuccuggcgc      540

uaccucucca accgccuccu cgcccccucc gacucccccg aguggcucuc cuucgacguc      600

accggcgucg uccgccagug gcucucccgc ggcggcgaga ucgagggcuu ccgccucucc      660

gcccacugcu ccugcgacuc ccgcgacaac acccuccagg ucgacaucaa cggcuucacc      720

accggccgcc gcggcgaccu cgccaccauc cacggcauga accgccccuu ccuccuccuc      780

auggccaccc cccucgagcg cgcccagcac cuccaguccu cccgccaccg ccgcgcccuc      840

gacaccaacu acugcuucuc cuccaccgag aagaacugcu gcguccgcca gcucuacauc      900

gacuuccgca aggaccucgg cuggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccucg gccccugccc cuacaucugg ucccucgaca cccaguacuc caagguccuc     1020

gcccucuaca accagcacaa ccccggcgcc uccgccgccc ccugcugcgu cccccaggcc     1080

cucgagcccc uccccaucgu cuacuacguc ggccgcaagc ccaaggucga gcagcucucc     1140

aacaugaucg uccgcuccug caagugcucc uga                                  1173


<210>  4781
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4781
augcccccua gcggccugag acuccuucug uuguuacugc cacuacucug gcugcuugug       60

cugaccccgg ggaggcccgc cgcuggauug uccacaugca agacuaucga cauggagcuc      120

gucaaacgga agcgcauuga agcaauacga ggucagaucc ugucuaaacu gcgucucgcc      180

ucaccuccaa gucaaggcga gguucccccu gggccauuac ccgaagcggu gcuggcucuu      240

uacaacagca cgagagauag gguagccgga gaguccgcag aaccugagcc agagccggaa      300

gccgacuauu acgcuaagga ggugacccgg gucuugaugg uggaaacaca caaugagauu      360

uaugauaaau ucaagcaguc uacucauucg aucuacaugu uuuucaacac cucagagcug      420

cgcgaagcag uucccgagcc ugugcuacuc agcagagccg aacugaggcu ucugcgguug      480

aagcucaaag ucgagcagca cguggaacug uaucagaagu acaguaauaa cuccuggcgc      540

uauuuaucua aucgacugcu cgcuccaagc gacucccccg aguggcuuuc auuugaugua      600

acaggcguug ugagacaaug gcugaguagg gguggggaga uugaaggauu ccgguugagc      660

gcccauuguu cuugcgacuc ccgugauaac acccuacagg ucgacaucaa uggcuuuacu      720

acaggccgca gaggggaucu ggcgaccaua cacggaauga acaggccuuu ccuccugcuu      780

auggcaacgc cacuggagcg ggcccagcau uugcagucaa gccgacaccg cagagcucuc      840

gacacuaauu acuguuuuag uucuaccgag aaaaacugcu gugugaggca acuguacauc      900

gauuuccgga aggacuuagg uuggaaaugg auucacgaac ccaagggcua ucaugccaau      960

uuuugccugg ggccgugucc uuacaucugg ucccuagaua cacaguauag caaggugcuc     1020

gcacuguaca accagcacaa ucccggagcu ucggccgcgc caugcugugu cccucaggcc     1080

cuugaacccu ugccaauugu uuauuacgug ggccgcaaac ccaagguaga gcaacugucu     1140

aacaugaucg ugagauccug caaauguuca uga                                  1173


<210>  4782
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4782
augcccccca gcggccugag acugcugcug cugcugcugc cccugcugug gcugcuggug       60

cugacccccg gcagacccgc cgccggccug agcaccugca agaccaucga cauggagcug      120

gugaagagaa agagaaucga ggccaucaga ggccagaucc ugagcaagcu gagacuggcc      180

agccccccca gccagggcga ggugcccccc ggcccccugc ccgaggccgu gcuggcccug      240

uacaacagca ccagagacag aguggccggc gagagcgccg agcccgagcc cgagcccgag      300

gccgacuacu acgccaagga ggugaccaga gugcugaugg uggagaccca caacgagauc      360

uacgacaagu ucaagcagag cacccacagc aucuacaugu ucuucaacac cagcgagcug      420

agagaggccg ugcccgagcc cgugcugcug agcagagccg agcugagacu gcugagacug      480

aagcugaagg uggagcagca cguggagcug uaccagaagu acagcaacaa cagcuggaga      540

uaccugagca acagacugcu ggcccccagc gacagccccg aguggcugag cuucgacgug      600

accggcgugg ugagacagug gcugagcaga ggcggcgaga ucgagggcuu cagacugagc      660

gcccacugca gcugcgacag cagagacaac acccugcagg uggacaucaa cggcuucacc      720

accggcagaa gaggcgaccu ggccaccauc cacggcauga acagacccuu ccugcugcug      780

auggccaccc cccuggagag agcccagcac cugcagagca gcagacacag aagagcccug      840

gacaccaacu acugcuucag cagcaccgag aagaacugcu gcgugagaca gcuguacauc      900

gacuucagaa aggaccuggg cuggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccugg gccccugccc cuacaucugg agccuggaca cccaguacag caaggugcug     1020

gcccuguaca accagcacaa ccccggcgcc agcgccgccc ccugcugcgu gccccaggcc     1080

cuggagcccc ugcccaucgu guacuacgug ggcagaaagc ccaaggugga gcagcugagc     1140

aacaugaucg ugagaagcug caagugcagc uga                                  1173


<210>  4783
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4783
augcccccua gcggccugag acuccugcuu cugcuccugc cgcuucugug gcuccuggug       60

cugacccccg ggcggccugc cgcuggacuc uccacaugca agacgaucga cauggagcug      120

gucaaacgca agagaauuga agccauccgg ggccagauuc uuucuaaacu gcgccucgcg      180

agcccucccu cccaagggga gguucccccu ggaccgcugc ccgaagcugu gcuugcccug      240

uacaacucua ccagagaucg gguggccggc gagagcgcug aaccugagcc cgagccugaa      300

gccgacuauu acgcuaagga ggucacacgc gugcucaugg uugaaaccca caaugagauc      360

uaugauaaau ucaagcaguc cacacauucu auuuacaugu uuuucaacac cagcgagcug      420

agagaagccg ugcccgagcc gguccugcuc ucccgggcgg aacugcgccu ucugagacuc      480

aagcugaaag uggagcagca cguugaacuu uaucagaagu acagcaauaa cucuuggcgg      540

uaucugucca aucgccuccu ggccccuagc gacucucccg aguggcuguc cuuugaugug      600

acaggggucg ugagacaaug gcucagccgg ggaggcgaga ucgaaggcuu ccgccugucu      660

gcucauuguu ccugcgacag cagagauaac acccuucagg uggacaucaa uggguuuacg      720

accggacgga gaggcgaucu ggccacaauu cacgggauga accgcccuuu ccuccugcuu      780

auggcuacac cccuggagcg ggcccagcau cuccaguccu cuagacaccg ccgggcgcug      840

gacaccaauu acuguuuuag cuccaccgag aaaaacugcu gugucagaca acuguacauc      900

gauuuccgca aggaccucgg auggaaaugg auucacgaac ccaagggcua ucaugccaau      960

uuuugccugg ggccuugucc guacaucugg agccuugaua cgcaguauuc uaagguucug     1020

gcucucuaca accagcacaa ucccggagcc uccgcugccc cuugcugugu gccccaggcc     1080

cuggaaccuc ugcccauugu guauuacguc ggccggaaac cgaaggugga gcaacuuagc     1140

aacaugaucg uuagaucuug caaauguagc uga                                  1173


<210>  4784
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TGFbeta1__Homo_sapiens__EAW57033

<400>  4784
augccaccau cuggacuaag acuuuuauua cuacuacuac cacuauuaug gcuuuuaguu       60

cuaacaccag gaaggccagc agcaggacua ucaacaugca aaaccauuga uauggaauua      120

guaaaacgaa aaagaaucga agccauacga ggacaaauac uaucaaaacu uagacuugca      180

agcccaccuu cccaaggcga aguaccuccc ggaccauuac cugaagcagu auuagcucua      240

uacaacucca cucgagaccg aguagccgga gaauccgccg aaccagaacc agaaccagaa      300

gcagauuacu acgcaaaaga aguaacaaga guuuugaugg uagaaacgca caacgaaaua      360

uaugacaaau ucaaacaauc cacacauucu auauacaugu ucuucaauac aucugaacua      420

agagaagcag uacccgaacc aguacuauua ucacgagccg aacuaagacu ucuccgacua      480

aaacuaaaag uagaacaaca cguugaacuu uaucaaaaau acucaaauaa uucauggaga      540

uauuuaucaa auagauuauu agcaccauca gacucuccag aauggcuauc auuugacgua      600

accggaguag uaagacaaug guuaucuaga ggaggagaaa uagaagguuu ccgauuauca      660

gcacacugcu caugcgauuc ccgagacaau acauuacaag ucgacauaaa uggauucaca      720

acaggcagaa gaggagaccu agcaacaaua cacggaauga auagaccauu ccuauuauua      780

auggcaacac cauuagaaag agcacaacac cuacaaucuu caagacacag aagagcacua      840

gacacaaacu acuguuucuc aucuacagaa aaaaacugcu gcgucagaca auuauauaua      900

gauuucagaa aagaccuugg auggaaaugg auucaugaac caaaaggaua ccacgcaaac      960

uucuguuuag gaccaugucc auacauaugg ucacuagaua cacaauacuc aaaaguucua     1020

gcacucuaca aucaacacaa cccaggagcu ucagccgcac caugcugugu accacaagcu     1080

cuagaaccac uuccaauagu uuacuaugua ggaagaaaac caaaaguaga acaauuauca     1140

aacaugaucg uacgaucaug uaaaugcuca uaa                                  1173


<210>  4785
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFbeta1__Homo_sapiens__P01137

<400>  4785

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  4786
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFbeta1__Homo_sapiens__AAH00125

<400>  4786
augccgcccu ccgggcugcg gcugcugcug cugcugcuac cgcugcugug gcuacuggug       60

cugacgccug gccggccggc cgcgggacua uccaccugca agacuaucga cauggagcug      120

gugaagcgga agcgcaucga ggccauccgc ggccagaucc uguccaagcu gcggcucgcc      180

agccccccga gccaggggga ggugccgccc ggcccgcugc ccgaggccgu gcucgcccug      240

uacaacagca cccgcgaccg gguggccggg gagagugcag aaccggagcc cgagccugag      300

gccgacuacu acgccaagga ggucacccgc gugcuaaugg uggaaaccca caacgaaauc      360

uaugacaagu ucaagcagag uacacacagc auauauaugu ucuucaacac aucagagcuc      420

cgagaagcgg uaccugaacc cguguugcuc ucccgggcag agcugcgucu gcugaggcuc      480

aaguuaaaag uggagcagca cguggagcug uaccagaaau acagcaacaa uuccuggcga      540

uaccucagca accggcugcu ggcacccagc gacucgccag agugguuauc uuuugauguc      600

accggaguug ugcggcagug guugagccgu ggaggggaaa uugagggcuu ucgccuuagc      660

gcccacugcu ccugugacag cagggauaac acacugcaag uggacaucaa cggguucacu      720

accggccgcc gaggugaccu ggccaccauu cauggcauga accggccuuu ccugcuucuc      780

auggccaccc cgcuggagag ggcccagcau cugcaaagcu cccggcaccg ccgagcccug      840

gacaccaacu auugcuucag cuccacggag aagaacugcu gcgugcggca gcuguacauu      900

gacuuccgca aggaccucgg cuggaagugg auccacgagc ccaagggcua ccaugccaac      960

uucugccucg ggcccugccc cuacauuugg agccuggaca cgcaguacag caagguccug     1020

gcccuguaca accagcauaa cccgggcgcc ucggcggcgc cgugcugcgu gccgcaggcg     1080

cuggagccgc ugcccaucgu guacuacgug ggccgcaagc ccaaggugga gcagcugucc     1140

aacaugaucg ugcgcuccug caagugcagc uga                                  1173


<210>  4787
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4787
augcccccga gcggccugcg ccuccugcug cuccugcugc cccuccugug gcugcucgug       60

cugacccccg ggcggcccgc cgccggccug uccacgugca agaccaucga cauggagcuc      120

gucaagcgca agcggaucga ggcgauccgc gggcagaucc ugagcaagcu gcggcucgcc      180

uccccgccca gccagggcga ggugccgccc gggccccugc ccgaggccgu gcuggcccuc      240

uacaacucca cccgcgaccg ggucgccggc gagagcgcgg agcccgagcc cgagccggag      300

gccgacuacu acgccaagga ggugacccgc gugcugaugg ucgagaccca caacgagauc      360

uacgacaagu ucaagcaguc cacgcacagc aucuacaugu ucuucaacac cuccgagcug      420

cgggaggccg ugcccgagcc cgugcuccug agccgcgcgg agcugcggcu ccugcgccug      480

aagcucaagg ucgagcagca cguggagcug uaccagaagu acuccaacaa cagcuggcgg      540

uaccugucca accgccuccu ggcccccagc gacuccccgg aguggcugag cuucgacgug      600

accggcgucg ugcggcagug gcucucccgc gggggcgaga ucgagggguu ccggcugagc      660

gcccacugcu ccugcgacag ccgcgacaac acccuccagg uggacaucaa cggcuucacg      720

accgggcggc gcggcgaccu ggccaccauc cacggcauga accggcccuu ccugcugcuc      780

auggccacgc cccuggagcg cgcgcagcac cuccagagcu cccgccaccg gcgcgcccug      840

gacaccaacu acugcuucag cuccaccgag aagaacugcu gcguccggca gcuguacauc      900

gacuuccgca aggaccuggg guggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccucg ggccgugccc cuacaucugg agccuggaca cccaguacuc caaggugcug     1020

gcccucuaca accagcacaa ccccggcgcc agcgcggccc ccugcugcgu gccgcaggcc     1080

cuggagcccc ugcccaucgu cuacuacgug ggccggaagc ccaaggugga gcagcugucc     1140

aacaugaucg uccgcagcug caagugcucc uga                                  1173


<210>  4788
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4788
augccccccu ccggccuccg ccuccuccuc cuccuccucc cccuccucug gcuccucguc       60

cucacccccg gccgccccgc cgccggccuc uccaccugca agaccaucga cauggagcuc      120

gucaagcgca agcgcaucga ggccauccgc ggccagaucc ucuccaagcu ccgccucgcc      180

uccccccccu cccagggcga gguccccccc ggcccccucc ccgaggccgu ccucgcccuc      240

uacaacucca cccgcgaccg cgucgccggc gaguccgccg agcccgagcc cgagcccgag      300

gccgacuacu acgccaagga ggucacccgc guccucaugg ucgagaccca caacgagauc      360

uacgacaagu ucaagcaguc cacccacucc aucuacaugu ucuucaacac cuccgagcuc      420

cgcgaggccg uccccgagcc cguccuccuc ucccgcgccg agcuccgccu ccuccgccuc      480

aagcucaagg ucgagcagca cgucgagcuc uaccagaagu acuccaacaa cuccuggcgc      540

uaccucucca accgccuccu cgcccccucc gacucccccg aguggcucuc cuucgacguc      600

accggcgucg uccgccagug gcucucccgc ggcggcgaga ucgagggcuu ccgccucucc      660

gcccacugcu ccugcgacuc ccgcgacaac acccuccagg ucgacaucaa cggcuucacc      720

accggccgcc gcggcgaccu cgccaccauc cacggcauga accgccccuu ccuccuccuc      780

auggccaccc cccucgagcg cgcccagcac cuccaguccu cccgccaccg ccgcgcccuc      840

gacaccaacu acugcuucuc cuccaccgag aagaacugcu gcguccgcca gcucuacauc      900

gacuuccgca aggaccucgg cuggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccucg gccccugccc cuacaucugg ucccucgaca cccaguacuc caagguccuc     1020

gcccucuaca accagcacaa ccccggcgcc uccgccgccc ccugcugcgu cccccaggcc     1080

cucgagcccc uccccaucgu cuacuacguc ggccgcaagc ccaaggucga gcagcucucc     1140

aacaugaucg uccgcuccug caagugcucc uga                                  1173


<210>  4789
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4789
augcccccua gcggccugag acuccuucug uuguuacugc cacuacucug gcugcuugug       60

cugaccccgg ggaggcccgc cgcuggauug uccacaugca agacuaucga cauggagcuc      120

gucaaacgga agcgcauuga agcaauacga ggucagaucc ugucuaaacu gcgucucgcc      180

ucaccuccaa gucaaggcga gguucccccu gggccauuac ccgaagcggu gcuggcucuu      240

uacaacagca cgagagauag gguagccgga gaguccgcag aaccugagcc agagccggaa      300

gccgacuauu acgcuaagga ggugacccgg gucuugaugg uggaaacaca caaugagauu      360

uaugauaaau ucaagcaguc uacucauucg aucuacaugu uuuucaacac cucagagcug      420

cgcgaagcag uucccgagcc ugugcuacuc agcagagccg aacugaggcu ucugcgguug      480

aagcucaaag ucgagcagca cguggaacug uaucagaagu acaguaauaa cuccuggcgc      540

uauuuaucua aucgacugcu cgcuccaagc gacucccccg aguggcuuuc auuugaugua      600

acaggcguug ugagacaaug gcugaguagg gguggggaga uugaaggauu ccgguugagc      660

gcccauuguu cuugcgacuc ccgugauaac acccuacagg ucgacaucaa uggcuuuacu      720

acaggccgca gaggggaucu ggcgaccaua cacggaauga acaggccuuu ccuccugcuu      780

auggcaacgc cacuggagcg ggcccagcau uugcagucaa gccgacaccg cagagcucuc      840

gacacuaauu acuguuuuag uucuaccgag aaaaacugcu gugugaggca acuguacauc      900

gauuuccgga aggacuuagg uuggaaaugg auucacgaac ccaagggcua ucaugccaau      960

uuuugccugg ggccgugucc uuacaucugg ucccuagaua cacaguauag caaggugcuc     1020

gcacuguaca accagcacaa ucccggagcu ucggccgcgc caugcugugu cccucaggcc     1080

cuugaacccu ugccaauugu uuauuacgug ggccgcaaac ccaagguaga gcaacugucu     1140

aacaugaucg ugagauccug caaauguuca uga                                  1173


<210>  4790
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4790
augcccccca gcggccugag acugcugcug cugcugcugc cccugcugug gcugcuggug       60

cugacccccg gcagacccgc cgccggccug agcaccugca agaccaucga cauggagcug      120

gugaagagaa agagaaucga ggccaucaga ggccagaucc ugagcaagcu gagacuggcc      180

agccccccca gccagggcga ggugcccccc ggcccccugc ccgaggccgu gcuggcccug      240

uacaacagca ccagagacag aguggccggc gagagcgccg agcccgagcc cgagcccgag      300

gccgacuacu acgccaagga ggugaccaga gugcugaugg uggagaccca caacgagauc      360

uacgacaagu ucaagcagag cacccacagc aucuacaugu ucuucaacac cagcgagcug      420

agagaggccg ugcccgagcc cgugcugcug agcagagccg agcugagacu gcugagacug      480

aagcugaagg uggagcagca cguggagcug uaccagaagu acagcaacaa cagcuggaga      540

uaccugagca acagacugcu ggcccccagc gacagccccg aguggcugag cuucgacgug      600

accggcgugg ugagacagug gcugagcaga ggcggcgaga ucgagggcuu cagacugagc      660

gcccacugca gcugcgacag cagagacaac acccugcagg uggacaucaa cggcuucacc      720

accggcagaa gaggcgaccu ggccaccauc cacggcauga acagacccuu ccugcugcug      780

auggccaccc cccuggagag agcccagcac cugcagagca gcagacacag aagagcccug      840

gacaccaacu acugcuucag cagcaccgag aagaacugcu gcgugagaca gcuguacauc      900

gacuucagaa aggaccuggg cuggaagugg auccacgagc ccaagggcua ccacgccaac      960

uucugccugg gccccugccc cuacaucugg agccuggaca cccaguacag caaggugcug     1020

gcccuguaca accagcacaa ccccggcgcc agcgccgccc ccugcugcgu gccccaggcc     1080

cuggagcccc ugcccaucgu guacuacgug ggcagaaagc ccaaggugga gcagcugagc     1140

aacaugaucg ugagaagcug caagugcagc uga                                  1173


<210>  4791
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4791
augcccccua gcggccugag acuccugcuu cugcuccugc cgcuucugug gcuccuggug       60

cugacccccg ggcggccugc cgcuggacuc uccacaugca agacgaucga cauggagcug      120

gucaaacgca agagaauuga agccauccgg ggccagauuc uuucuaaacu gcgccucgcg      180

agcccucccu cccaagggga gguucccccu ggaccgcugc ccgaagcugu gcuugcccug      240

uacaacucua ccagagaucg gguggccggc gagagcgcug aaccugagcc cgagccugaa      300

gccgacuauu acgcuaagga ggucacacgc gugcucaugg uugaaaccca caaugagauc      360

uaugauaaau ucaagcaguc cacacauucu auuuacaugu uuuucaacac cagcgagcug      420

agagaagccg ugcccgagcc gguccugcuc ucccgggcgg aacugcgccu ucugagacuc      480

aagcugaaag uggagcagca cguugaacuu uaucagaagu acagcaauaa cucuuggcgg      540

uaucugucca aucgccuccu ggccccuagc gacucucccg aguggcuguc cuuugaugug      600

acaggggucg ugagacaaug gcucagccgg ggaggcgaga ucgaaggcuu ccgccugucu      660

gcucauuguu ccugcgacag cagagauaac acccuucagg uggacaucaa uggguuuacg      720

accggacgga gaggcgaucu ggccacaauu cacgggauga accgcccuuu ccuccugcuu      780

auggcuacac cccuggagcg ggcccagcau cuccaguccu cuagacaccg ccgggcgcug      840

gacaccaauu acuguuuuag cuccaccgag aaaaacugcu gugucagaca acuguacauc      900

gauuuccgca aggaccucgg auggaaaugg auucacgaac ccaagggcua ucaugccaau      960

uuuugccugg ggccuugucc guacaucugg agccuugaua cgcaguauuc uaagguucug     1020

gcucucuaca accagcacaa ucccggagcc uccgcugccc cuugcugugu gccccaggcc     1080

cuggaaccuc ugcccauugu guauuacguc ggccggaaac cgaaggugga gcaacuuagc     1140

aacaugaucg uuagaucuug caaauguagc uga                                  1173


<210>  4792
<211>  1173
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TGFbeta1__Homo_sapiens__AAH00125

<400>  4792
augccaccau caggauuaag auuacuacua uuacuacuac cacuucuaug guuauuagua       60

cuaacaccag gaagacccgc cgcaggacua ucaacaugca aaacaauaga cauggaauua      120

guaaaaagaa aacgcauaga agcaauaaga ggacaaauau uaucaaaauu aagacuagca      180

uccccacccu cacaaggaga agucccacca ggcccacuac cagaagcagu acuagcacua      240

uacaacucaa caagagacag aguagcagga gaaucagcag aaccugaacc ggaaccagaa      300

gcagacuacu acgcaaaaga aguaacaaga guacuaaugg uugaaacuca uaacgaaaua      360

uaugacaaau ucaaacaauc aacacauuca auuuauaugu ucuuuaacac aucagaacua      420

agagaagcag uuccugaacc aguccuauua uccagagcag aauuaagacu auuaagauua      480

aaauuaaaag uagaacaaca uguagaacua uaucaaaaau acucaaacaa uucuuggaga      540

uaccuaucca aucgucuccu agccccauca gauuccccag aauggcuauc auucgauguc      600

acaggaguag uaaggcaaug guuauccaga ggaggagaaa uagaaggauu uagacuauca      660

gcacacugca guugcgacuc uagagacaau acucuacaag uagauauaaa uggcuuuaca      720

acaggacgua ggggagauuu agcaacuaua cacgguauga aucgaccauu ucuauuacua      780

auggcaacac cacuugaacg ugcucaacac uuacaaucuu cacgccacag aagagcacuc      840

gacacaaauu acugcuucuc aagcacagaa aaaaacugcu gcguuagaca auuauacaua      900

gacuucagaa aagauuuagg auggaaaugg auccacgaac caaaaggaua ccaugccaac      960

uucuguuuag gaccaugccc auacauaugg ucacuagaca cacaauacuc aaaaguccua     1020

gcucuauaua aucaacauaa cccaggugcc uccgcagccc cuuguugugu accccaagca     1080

cuagaaccau uaccaauagu auauuacgua ggaagaaaac caaaaguaga acaacuauca     1140

aauaugauag uaagaagcug caaauguuca uaa                                  1173


<210>  4793
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFbeta2__Homo_sapiens__P61812

<400>  4793

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  4794
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFbeta2__Homo_sapiens__AAH96235

<400>  4794
augcacuacu gugugcugag cgcuuuucug auccugcauc uggucacggu cgcgcucagc       60

cugucuaccu gcagcacacu cgauauggac caguucaugc gcaagaggau cgaggcgauc      120

cgcgggcaga uccugagcaa gcugaagcuc accagucccc cagaagacua uccugagccc      180

gaggaagucc ccccggaggu gauuuccauc uacaacagca ccagggacuu gcuccaggag      240

aaggcgagcc ggagggcggc cgccugcgag cgcgagagga gcgacgaaga guacuacgcc      300

aaggagguuu acaaaauaga caugccgccc uucuuccccu ccgaaaaugc caucccgccc      360

acuuucuaca gacccuacuu cagaauuguu cgauuugacg ucucagcaau ggagaagaau      420

gcuuccaauu uggugaaagc agaguucaga gucuuucguu ugcagaaccc aaaagccaga      480

gugccugaac aacggauuga gcuauaucag auucucaagu ccaaagauuu aacaucucca      540

acccagcgcu acaucgacag caaaguugug aaaacaagag cagaaggcga auggcucucc      600

uucgauguaa cugaugcugu ucaugaaugg cuucaccaua aagacaggaa ccugggauuu      660

aaaauaagcu uacacugucc cugcugcacu uuuguaccau cuaauaauua caucauccca      720

aauaaaagug aagaacuaga agcaagauuu gcagguauug auggcaccuc cacauauacc      780

aguggugauc agaaaacuau aaaguccacu aggaaaaaaa acagugggaa gaccccacau      840

cuccugcuaa uguuauugcc cuccuacaga cuugagucac aacagaccaa ccggcggaag      900

aagcgugcuu uggaugcggc cuauugcuuu agaaaugugc aggauaauug cugccuacgu      960

ccacuuuaca uugauuucaa gagggaucua ggguggaaau ggauacacga acccaaaggg     1020

uacaaugcca acuucugugc uggagcaugc ccguauuuau ggaguucaga cacucagcac     1080

agcagggucc ugagcuuaua uaauaccaua aauccagaag caucugcuuc uccuugcugc     1140

gugucccaag auuuagaacc ucuaaccauu cucuacuaca uuggcaaaac acccaagauu     1200

gaacagcuuu cuaauaugau uguaaagucu ugcaaaugca gcuaa                     1245


<210>  4795
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4795
augcacuacu gcgugcugag cgccuuccuc auccugcacc uggucaccgu ggcccucucc       60

cugagcacgu gcuccacccu ggacauggac caguucaugc gcaagcggau cgaggcgauc      120

cgcggccaga uccucagcaa gcugaagcug accagcccgc ccgaggacua ccccgagccc      180

gaggaggugc ccccggaggu caucuccauc uacaacucca cccgggaccu ccugcaggag      240

aaggccagcc gccgggccgc cgccugcgag cgcgagcggu ccgacgagga guacuacgcg      300

aaggaggugu acaagaucga caugccgccc uucuucccca gcgagaacgc caucccgccc      360

accuucuacc gccccuacuu ccggaucgug cgcuucgacg ucuccgccau ggagaagaac      420

gccagcaacc uggugaaggc ggaguuccgg guguuccgcc uccagaaccc caaggcccgg      480

guccccgagc agcgcaucga gcuguaccag auccugaagu ccaaggaccu cacgagcccc      540

acccagcggu acaucgacuc caagguggug aagacccgcg ccgaggggga guggcugagc      600

uucgacguca ccgacgccgu gcacgagugg cugcaccaca aggaccggaa ccucggcuuc      660

aagaucuccc ugcacugccc cugcugcacg uucgugccca gcaacaacua caucaucccg      720

aacaaguccg aggagcugga ggcccgcuuc gcggggaucg acggcaccag caccuacacc      780

agcggggacc agaagacgau caaguccacc cggaagaaga acagcggcaa gacgccccac      840

cuccugcuga ugcuccugcc cuccuaccgc cuggagagcc agcagaccaa ccggcgcaag      900

aagcgcgccc ucgacgccgc cuacugcuuc cggaacgucc aggacaacug cugccugcgc      960

ccccuguaca ucgacuucaa gcgggaccuc ggcuggaagu ggauccacga gccgaagggg     1020

uacaacgcca acuucugcgc gggcgccugc cccuaccugu gguccagcga cacccagcac     1080

ucccgcgugc ugagccucua caacaccauc aaccccgagg ccuccgccag ccccugcugc     1140

gugucccagg accuggagcc gcugaccauc cucuacuaca ucgggaagac ccccaagauc     1200

gagcagcuga gcaacaugau cgucaagucc ugcaagugca gcuga                     1245


<210>  4796
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4796
augcacuacu gcguccucuc cgccuuccuc auccuccacc ucgucaccgu cgcccucucc       60

cucuccaccu gcuccacccu cgacauggac caguucaugc gcaagcgcau cgaggccauc      120

cgcggccaga uccucuccaa gcucaagcuc accucccccc ccgaggacua ccccgagccc      180

gaggaggucc cccccgaggu caucuccauc uacaacucca cccgcgaccu ccuccaggag      240

aaggccuccc gccgcgccgc cgccugcgag cgcgagcgcu ccgacgagga guacuacgcc      300

aaggaggucu acaagaucga caugcccccc uucuuccccu ccgagaacgc cauccccccc      360

accuucuacc gccccuacuu ccgcaucguc cgcuucgacg ucuccgccau ggagaagaac      420

gccuccaacc ucgucaaggc cgaguuccgc gucuuccgcc uccagaaccc caaggcccgc      480

guccccgagc agcgcaucga gcucuaccag auccucaagu ccaaggaccu caccuccccc      540

acccagcgcu acaucgacuc caaggucguc aagacccgcg ccgagggcga guggcucucc      600

uucgacguca ccgacgccgu ccacgagugg cuccaccaca aggaccgcaa ccucggcuuc      660

aagaucuccc uccacugccc cugcugcacc uucguccccu ccaacaacua caucaucccc      720

aacaaguccg aggagcucga ggcccgcuuc gccggcaucg acggcaccuc caccuacacc      780

uccggcgacc agaagaccau caaguccacc cgcaagaaga acuccggcaa gaccccccac      840

cuccuccuca ugcuccuccc cuccuaccgc cucgaguccc agcagaccaa ccgccgcaag      900

aagcgcgccc ucgacgccgc cuacugcuuc cgcaacgucc aggacaacug cugccuccgc      960

ccccucuaca ucgacuucaa gcgcgaccuc ggcuggaagu ggauccacga gcccaagggc     1020

uacaacgcca acuucugcgc cggcgccugc cccuaccucu gguccuccga cacccagcac     1080

ucccgcgucc ucucccucua caacaccauc aaccccgagg ccuccgccuc ccccugcugc     1140

gucucccagg accucgagcc ccucaccauc cucuacuaca ucggcaagac ccccaagauc     1200

gagcagcucu ccaacaugau cgucaagucc ugcaagugcu ccuga                     1245


<210>  4797
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4797
augcacuacu gcgugcugag cgccuuccuc auccuucauc uggucaccgu ugcuuugucc       60

uuaucuacau guucaacucu ggacauggau caguuuauga gaaagaggau ugaggcaaua      120

cggggccaaa uccuaaguaa acucaagcug acgagcccuc ccgaagacua uccagagccg      180

gaagaggugc ccccugaagu aauuuccauc uacaacucua cccgcgaucu ucugcaggag      240

aaagccucgc gacgugcggc ugccugcgag agagaaaggu cagacgagga auauuacgca      300

aaggaggugu auaaaauuga uaugccaccc uucuuuccua gcgagaaugc caucccaccc      360

acauucuacc ggccuuauuu ucgcauaguc agauucgacg ugagugcuau ggaaaagaac      420

gcauccaauu ugguuaaggc cgaguuuagg guguuccggc uccagaaccc aaaagcucgc      480

gucccggaac agcgaaucga gcuguaccaa auucugaagu cuaaagaucu cacuagcccc      540

acccagagau acaucgacuc caagguggua aaaacaaggg ccgaagggga gugguuauca      600

uuugauguua ccgacgcggu gcacgagugg cugcaucaca aggaucggaa ucuuggauuc      660

aagauuaguu ugcauugucc uugcuguacu uuugucccaa gcaacaauua uaucauaccc      720

aacaaaucug aggaacugga agcacguuuc gccgguauug acggcacauc caccuacacg      780

ucaggggauc agaagacuau caaaagcacc cgcaagaaaa auaguggaaa gacaccucac      840

cuacuccuga ugcuucugcc aucuuauaga uuggaguccc agcaaacuaa caggcggaaa      900

aagcgagcuc ucgacgccgc auacugcuuu cgcaaugugc aggacaacug uugccugaga      960

cccuuauaua uugauuucaa gagggaccug ggcuggaaau ggauccacga accgaagggu     1020

uacaaugcua acuucugugc cggggcgugc ccuuaucucu ggagcucgga uacccagcau     1080

ucucgggugc uuucccugua caauacaauc aaccccgagg ccucagcaag uccauguugc     1140

gucagccagg acuuggagcc ucuaaccauu cuguacuaua uaggaaaaac gcccaagauc     1200

gaacaacucu ccaacaugau uguuaaaucu ugcaagugua gcuga                     1245


<210>  4798
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4798
augcacuacu gcgugcugag cgccuuccug auccugcacc uggugaccgu ggcccugagc       60

cugagcaccu gcagcacccu ggacauggac caguucauga gaaagagaau cgaggccauc      120

agaggccaga uccugagcaa gcugaagcug accagccccc ccgaggacua ccccgagccc      180

gaggaggugc cccccgaggu gaucagcauc uacaacagca ccagagaccu gcugcaggag      240

aaggccagca gaagagccgc cgccugcgag agagagagaa gcgacgagga guacuacgcc      300

aaggaggugu acaagaucga caugcccccc uucuucccca gcgagaacgc cauccccccc      360

accuucuaca gacccuacuu cagaaucgug agauucgacg ugagcgccau ggagaagaac      420

gccagcaacc uggugaaggc cgaguucaga guguucagac ugcagaaccc caaggccaga      480

gugcccgagc agagaaucga gcuguaccag auccugaaga gcaaggaccu gaccagcccc      540

acccagagau acaucgacag caagguggug aagaccagag ccgagggcga guggcugagc      600

uucgacguga ccgacgccgu gcacgagugg cugcaccaca aggacagaaa ccugggcuuc      660

aagaucagcc ugcacugccc cugcugcacc uucgugccca gcaacaacua caucaucccc      720

aacaagagcg aggagcugga ggccagauuc gccggcaucg acggcaccag caccuacacc      780

agcggcgacc agaagaccau caagagcacc agaaagaaga acagcggcaa gaccccccac      840

cugcugcuga ugcugcugcc cagcuacaga cuggagagcc agcagaccaa cagaagaaag      900

aagagagccc uggacgccgc cuacugcuuc agaaacgugc aggacaacug cugccugaga      960

ccccuguaca ucgacuucaa gagagaccug ggcuggaagu ggauccacga gcccaagggc     1020

uacaacgcca acuucugcgc cggcgccugc cccuaccugu ggagcagcga cacccagcac     1080

agcagagugc ugagccugua caacaccauc aaccccgagg ccagcgccag ccccugcugc     1140

gugagccagg accuggagcc ccugaccauc cuguacuaca ucggcaagac ccccaagauc     1200

gagcagcuga gcaacaugau cgugaagagc ugcaagugca gcuga                     1245


<210>  4799
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4799
augcacuacu gcgugcugag cgccuuccuc auccugcauc uugucaccgu ugcucugucc       60

cucucuacau guagcacgcu ggacauggau caguuuauga gaaagcggau ugaggccauc      120

cgcggccaaa uucuuuccaa acugaagcuc accucucccc cugaagacua uccggagccc      180

gaagaggugc cucccgaagu gaucagcauu uacaacucca caagagaucu gcugcaggag      240

aaagcgucuc ggcgcgcugc cgccugcgag agagaacgga gcgacgagga auauuacgcu      300

aaggaggucu auaaaaucga uaugccuccc uucuuuccuu ccgagaaugc caucccgccc      360

accuucuacc gcccuuauuu uagaauugug cgguucgacg uuagcgcuau ggaaaagaac      420

gccucuaauc ucgugaaggc ggaguuucgc gucuucagac ugcagaaccc caaagcccgg      480

gugccugaac agcgcaucga gcuuuaccaa auucugaagu ccaaagaucu cacaagcccc      540

acccagagau acaucgacuc uaagguugug aaaacacggg cugaagggga guggcugucc      600

uuugauguca ccgacgccgu gcacgagugg cuucaucaca aggaucgcaa ucugggauuc      660

aagauuagcc uccauugucc gugcuguacg uuugugccuu cuaacaauua uaucauuccc      720

aacaaauccg aggaacugga agcuagauuc gccggcaucg acgggaccag cacauacacc      780

uccggagauc agaagacaau caaaucuacc cggaagaaaa auagcggcaa gacgccucau      840

cugcuccuga ugcuucugcc cuccuauaga cucgagagcc agcaaacaaa ccgccggaaa      900

aagagagcgc uggacgccgc uuacugcuuu cgcaaugucc aggacaacug uugccuucgg      960

ccccuguaua uugauuucaa gagagaccuc ggguggaaau ggauccacga accuaaggga     1020

uacaaugcca acuucugugc uggcgccugc ccguaucugu ggucuuccga uacccagcac     1080

agccgcguuc ugucucucua caauacaauu aaccccgagg ccagcgcuuc cccuuguugc     1140

gugucucagg accuggagcc ccuuaccauc cuguacuaua uuggcaaaac cccuaagauc     1200

gaacaacuca gcaacaugau cgugaaaucc ugcaagugua gcuga                     1245


<210>  4800
<211>  1245
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TGFbeta2__Homo_sapiens__AAH96235

<400>  4800
augcacuacu gcguacuauc agccuucuua auacuacacc uaguaacagu agcauuaucc       60

uuaucaacau gcucaacauu agacauggau caauucaugc guaaaagaau cgaagcuauu      120

agaggacaaa uacuuucaaa acucaaacuc accucuccac cagaagauua cccagaacca      180

gaagaaguac ccccagaagu aauuucaaua uacaauucaa caagagaucu acuccaagaa      240

aaagcaucac gaagagcagc agccugcgaa agagaacguu cagaugaaga auacuaugca      300

aaagaaguau acaaaauaga caugccacca uucuuuccau cugaaaacgc aauaccacca      360

accuucuaca gaccauauuu ccgcauaguc agauucgacg ucucagcaau ggaaaaaaau      420

gcauccaacc uaguaaaagc agaauuccga guauucagac uccaaaaccc caaagcccga      480

gucccagaac aacgcauaga acucuaucaa auacuaaaau ccaaagacuu aacaucccca      540

acccaaagau auauugacuc aaaaguagua aaaacaagag ccgaaggaga augguuauca      600

uuugacguaa ccgacgccgu acaugaaugg cuacaccaca aagacagaaa cuuaggauuc      660

aaaauauccc uacacugccc auguugcaca uucguaccua gcaacaauua cauaauccca      720

aacaaaucag aagaacuaga agcaagauuc gccgguauag acggaacauc uacuuacaca      780

uccggagacc aaaaaacaau aaaaucaaca agaaaaaaaa acucaggcaa aacaccacac      840

uuacuccuca ugcuauuacc aucauauaga uuagaauccc aacaaacaaa uagaagaaaa      900

aaacgcgccc uagaugcagc auauuguuuu cgaaacguac aagauaauug cugucuaaga      960

ccacucuaca uugacuuuaa acgagaccua ggauggaaau ggauccacga accaaaagga     1020

uauaacgcaa acuucugcgc aggugcaugu cccuaccuau gguccucaga cacacaacac     1080

ucaagaguac ucucacuaua uaacacaaua aaucccgaag caucggcaag cccaugcugc     1140

guaucacaag aucuagaacc acucacaaua cuguauuaca uaggaaaaac acccaaaaua     1200

gaacaacucu caaacaugau aguaaaaucc uguaaaugcu cauaa                     1245


<210>  4801
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFbeta3__Homo_sapiens__A5YM40

<400>  4801

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  4802
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFbeta3__Homo_sapiens__ABQ59024

<400>  4802
augaagaugc acuugcaaag ggcucuggug guccuggccc ugcugaacuu ugccacgguc       60

agccucucuc uguccacuug caccaccuug gacuucggcc acaucaagaa gaagagggug      120

gaagccauua ggggacagau cuugagcaag cucaggcuca ccagcccccc ugagccaacg      180

gugaugaccc acguccccua ucagguccug gcccuuuaca acagcacccg ggagcugcug      240

gaggagaugc auggggagag ggaggaaggc ugcacccagg aaaacaccga gucggaauac      300

uaugccaaag aaauccauaa auucgacaug auccaggggc uggcggagca caacgaacug      360

gcugucugcc cuaaaggaau uaccuccaag guuuuccgcu ucaauguguc cucaguggag      420

aaaaauagaa ccaaccuauu ccgagcagaa uuccgggucu ugcgggugcc caaccccagc      480

ucuaagcgga augagcagag gaucgagcuc uuccagaucc uucggccaga ugagcacauu      540

gccaaacagc gcuauaucgg uggcaagaau cugcccacac ggggcacugc cgaguggcug      600

uccuuugaug ucacugacac ugugcgugag uggcuguuga gaagagaguc caacuuaggu      660

cuagaaauca gcauucacug uccaugucac accuuucagc ccaauggaga uauccuggaa      720

aacauucacg aggugaugga aaucaaauuc aaaggcgugg acaaugagga ugaccauggc      780

cguggagauc uggggcgccu caagaagcag aaggaucacc acaacccuca ucuaauccuc      840

augaugauuc ccccacaccg gcucgacaac ccgggccagg ggggucagag gaagaagcgg      900

gcuuuggaca ccaauuacug cuuccgcaac uuggaggaga acugcugugu gcgcccccuc      960

uacauugacu uccgacagga ucugggcugg aagugggucc augaaccuaa gggcuacuau     1020

gccaacuucu gcucaggccc uugcccauac cuccgcagug cagacacaac ccacagcacg     1080

gugcugggac uguacaacac ucugaacccu gaagcaucug ccucgccuug cugcgugccc     1140

caggaccugg agccccugac cauccuguac uauguuggga ggacccccaa aguggagcag     1200

cucuccaaca ugguggugaa gucuuguaaa uguagcuga                            1239


<210>  4803
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4803
augaagaugc accuccagcg cgcccucgug gugcuggccc ugcucaacuu cgcgaccgug       60

agccuguccc ugagcacgug caccacccuc gacuucggcc acaucaagaa gaagcgggug      120

gaggccaucc gcgggcagau ccuguccaag cugcggcuca ccagcccgcc cgagcccacc      180

gucaugacgc acgugcccua ccaggugcug gcccuguaca acuccacccg cgagcuccug      240

gaggagaugc acggcgagcg ggaggagggg ugcacccagg agaacaccga gagcgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc uggccgagca caacgagcuc      360

gcggucugcc ccaaggggau cacguccaag guguuccgcu ucaacgugag cuccgucgag      420

aagaaccgga ccaaccuguu ccgcgccgag uuccgggugc ugcgcgugcc gaaccccagc      480

uccaagcgga acgagcagcg caucgagcug uuccagaucc ugcggcccga cgagcacauc      540

gccaagcagc gcuacaucgg cggcaagaac cugcccaccc gggggaccgc cgaguggcuc      600

agcuucgacg ucacggacac cgugcgcgag uggcugcugc ggcgcgaguc caaccucggc      660

cuggagauca gcauccacug cccgugccac accuuccagc ccaacgggga cauccuggag      720

aacauccacg aggugaugga gaucaaguuc aagggcgucg acaacgagga cgaccacggg      780

cggggcgacc ucggccgccu gaagaagcag aaggaccacc acaaccccca ccugauccuc      840

augaugaucc cgccccaccg gcuggacaac cccgggcagg gcgggcagcg caagaagcgc      900

gcgcuggaca ccaacuacug cuuccggaac cucgaggaga acugcugcgu gcgcccccug      960

uacaucgacu uccggcagga ccugggcugg aagugggugc acgagcccaa gggcuacuac     1020

gccaacuucu gcuccgggcc gugccccuac cuccgcagcg ccgacacgac ccacuccacc     1080

guccugggcc uguacaacac ccucaacccc gaggccagcg ccucccccug cugcgugccg     1140

caggaccugg agccccugac gauccucuac uacguggggc ggacccccaa ggucgagcag     1200

cugagcaaca ugguggucaa gagcugcaag ugcuccuga                            1239


<210>  4804
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4804
augaagaugc accuccagcg cgcccucguc guccucgccc uccucaacuu cgccaccguc       60

ucccucuccc ucuccaccug caccacccuc gacuucggcc acaucaagaa gaagcgcguc      120

gaggccaucc gcggccagau ccucuccaag cuccgccuca ccuccccccc cgagcccacc      180

gucaugaccc acguccccua ccagguccuc gcccucuaca acuccacccg cgagcuccuc      240

gaggagaugc acggcgagcg cgaggagggc ugcacccagg agaacaccga guccgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc ucgccgagca caacgagcuc      360

gccgucugcc ccaagggcau caccuccaag gucuuccgcu ucaacgucuc cuccgucgag      420

aagaaccgca ccaaccucuu ccgcgccgag uuccgcgucc uccgcguccc caaccccucc      480

uccaagcgca acgagcagcg caucgagcuc uuccagaucc uccgccccga cgagcacauc      540

gccaagcagc gcuacaucgg cggcaagaac cuccccaccc gcggcaccgc cgaguggcuc      600

uccuucgacg ucaccgacac cguccgcgag uggcuccucc gccgcgaguc caaccucggc      660

cucgagaucu ccauccacug ccccugccac accuuccagc ccaacggcga cauccucgag      720

aacauccacg aggucaugga gaucaaguuc aagggcgucg acaacgagga cgaccacggc      780

cgcggcgacc ucggccgccu caagaagcag aaggaccacc acaaccccca ccucauccuc      840

augaugaucc ccccccaccg ccucgacaac cccggccagg gcggccagcg caagaagcgc      900

gcccucgaca ccaacuacug cuuccgcaac cucgaggaga acugcugcgu ccgcccccuc      960

uacaucgacu uccgccagga ccucggcugg aagugggucc acgagcccaa gggcuacuac     1020

gccaacuucu gcuccggccc cugccccuac cuccgcuccg ccgacaccac ccacuccacc     1080

guccucggcc ucuacaacac ccucaacccc gaggccuccg ccucccccug cugcgucccc     1140

caggaccucg agccccucac cauccucuac uacgucggcc gcacccccaa ggucgagcag     1200

cucuccaaca uggucgucaa guccugcaag ugcuccuga                            1239


<210>  4805
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4805
augaagaugc aucugcagag agcccucgug guccuugcuc uguugaacuu cgcaaccguu       60

agcuuauccc ugucuacaug cacuacgcua gacuuuggcc acaucaaaaa gaaaagggug      120

gaggccauuc gggggcaaau acucucaaag cugcgccuua ccaguccccc ugaaccaaca      180

guaaugacuc acgugccgua ccagguccug gcguuguaua auagcacccg agagcuccug      240

gaagagaugc auggagaacg ugaggagggu uguacacagg aaaacaccga guccgaauac      300

uaugcuaaag agauccacaa guucgauaug auucagggcc uggccgagca uaaugaacuc      360

gcagugugcc ccaaggggau cacuucuaaa guuuuuagau ucaacguguc gucagucgag      420

aagaauagga caaacuuauu ucgggccgag uuccgcgugc ugagaguacc uaauccaagc      480

aguaaaagga acgaacaacg gauugaacuu uuucagaucu ugcgccccga cgagcacaua      540

gcuaagcagc gauacaucgg aggcaaaaau cugccuacca gagguacggc agaguggcua      600

uccuucgaug uuacugacac cgugagggaa uggcuccugc ggcgugaguc uaaccuuggg      660

cuggaaauua gcauccacug uccaugccau acauuucagc ccaauggaga uauuuuggag      720

aacauccacg aagucaugga gauaaaguuc aagggcgugg acaaugagga ugaccauggc      780

cgcggggauc ucggaagacu gaaaaagcaa aaagaccacc acaacccuca uuuaauucug      840

augaugaucc caccgcacag gcucgauaau cccggucagg gcgggcagcg gaagaaacga      900

gcccuugaca cuaacuauug uuuucgcaac cuggaagaga auugcugugu gagaccuuug      960

uacauugauu ucaggcagga ccuaggaugg aagugggucc augaaccaaa aggcuauuac     1020

gcuaacuuuu gcuccggucc cuguccuuac cugcggucag ccgacaccac acacaguacc     1080

guucucgggc uguauaauac gcuuaaccca gaggcgagcg caucucccug cugugugccg     1140

caagaucugg aaccuuugac uauccucuac uauguaggac gcacacccaa gguggagcag     1200

cuguccaaua uggucgugaa gucaugcaaa ugcagcuga                            1239


<210>  4806
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4806
augaagaugc accugcagag agcccuggug gugcuggccc ugcugaacuu cgccaccgug       60

agccugagcc ugagcaccug caccacccug gacuucggcc acaucaagaa gaagagagug      120

gaggccauca gaggccagau ccugagcaag cugagacuga ccagcccccc cgagcccacc      180

gugaugaccc acgugcccua ccaggugcug gcccuguaca acagcaccag agagcugcug      240

gaggagaugc acggcgagag agaggagggc ugcacccagg agaacaccga gagcgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc uggccgagca caacgagcug      360

gccgugugcc ccaagggcau caccagcaag guguucagau ucaacgugag cagcguggag      420

aagaacagaa ccaaccuguu cagagccgag uucagagugc ugagagugcc caaccccagc      480

agcaagagaa acgagcagag aaucgagcug uuccagaucc ugagacccga cgagcacauc      540

gccaagcaga gauacaucgg cggcaagaac cugcccacca gaggcaccgc cgaguggcug      600

agcuucgacg ugaccgacac cgugagagag uggcugcuga gaagagagag caaccugggc      660

cuggagauca gcauccacug ccccugccac accuuccagc ccaacggcga cauccuggag      720

aacauccacg aggugaugga gaucaaguuc aagggcgugg acaacgagga cgaccacggc      780

agaggcgacc ugggcagacu gaagaagcag aaggaccacc acaaccccca ccugauccug      840

augaugaucc ccccccacag acuggacaac cccggccagg gcggccagag aaagaagaga      900

gcccuggaca ccaacuacug cuucagaaac cuggaggaga acugcugcgu gagaccccug      960

uacaucgacu ucagacagga ccugggcugg aagugggugc acgagcccaa gggcuacuac     1020

gccaacuucu gcagcggccc cugccccuac cugagaagcg ccgacaccac ccacagcacc     1080

gugcugggcc uguacaacac ccugaacccc gaggccagcg ccagccccug cugcgugccc     1140

caggaccugg agccccugac cauccuguac uacgugggca gaacccccaa gguggagcag     1200

cugagcaaca ugguggugaa gagcugcaag ugcagcuga                            1239


<210>  4807
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4807
augaagaugc accuucagag agcccucgug guccuggcuc ugcugaacuu cgccaccguu       60

agccucuccc ugucuacaug cacgacccuu gacuuuggcc auaucaaaaa gaaacgggug      120

gaggcgauuc gcgggcaaau ccugagcaag cucagacuga caucuccccc ugaaccgacc      180

gugaugacac acguccccua ccaggugcug gcucucuaua auuccacccg ggagcugcuu      240

gaagagaugc auggagaacg cgaggagggc uguacacagg aaaacaccga gagcgaauac      300

uaugccaaag agauucacaa guucgauaug auccaggggc uggccgagca uaaugaacuc      360

gcuguuugcc cuaagggaau uacguccaaa guguuuagau ucaacgucuc uagcguggag      420

aagaaucgga ccaaccuguu ucgcgccgag uucagaguuc uucgggugcc caauccuucc      480

agcaaacgca acgaacaaag aaucgaacug uuucagaucc uccggcccga cgagcacauu      540

gcuaagcagc gcuacaucgg cgggaaaaau cugccuacaa gaggaaccgc cgaguggcug      600

ucuuucgaug ucacagacac cgugcgggaa uggcuccugc gcagagaguc caaccuuggc      660

cuggaaauua gcauccacug uccgugccau acguuucagc ccaauggcga uauucucgag      720

aacauccacg aagugaugga gauuaaguuc aagggggucg acaaugagga ugaccaugga      780

cggggcgauc uggggagacu uaaaaagcaa aaagaccacc acaacccuca ucugauccuc      840

augaugauuc ccccucaccg ccuggauaau cccggacagg gcgggcagcg gaagaaaaga      900

gcgcuggaca caaacuauug uuuucgcaac cucgaagaga auugcugugu ucggccgcug      960

uacaucgauu ucagacagga ccuuggaugg aagugggugc augaaccuaa aggcuauuac     1020

gccaacuuuu gcucuggccc cuguccuuac cugcgcuccg cugacaccac acacagcacc     1080

gugcucgggc uguauaauac ccuuaacccc gaggccucug cuucccccug cugugucccu     1140

caagaucugg aaccgcucac aauccuguac uaugugggac ggacgcccaa gguugagcag     1200

cugagcaaua ugguggucaa guccugcaaa ugcucuuga                            1239


<210>  4808
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TGFbeta3__Homo_sapiens__ABQ59024

<400>  4808
augaaaaugc accuacaacg agcacuagua guacuagcac uacucaauuu cgccacagua       60

ucacuaucac uaucaacaug cacaacccua gacuuuggac acauaaaaaa aaaaagggua      120

gaagcaauca gaggacaaau uuuaucaaaa cucagauuaa caucaccacc agaaccaaca      180

guuaugacac acguaccaua ccaaguccuc gcauuauaua acagcacacg agaacuauua      240

gaagaaaugc acggugaaag agaagaagga ugcacacaag aaaacacuga aucagaauac      300

uacgcaaaag aaauccauaa auucgacaug auccaaggac uagcagaaca uaacgaauua      360

gccguaugcc caaaaggcau aaccucaaaa guauucagau ucaacgucuc aagcguagaa      420

aaaaaccgua caaacuuauu ccgagcggaa uucagaguuc uaagaguacc aaauccuuca      480

ucaaaaagaa acgaacagag aauagaauua uuucaaauac uccgaccaga cgaacacaua      540

gcaaaacaaa gauacauagg aggaaaaaac cuaccaacaa gaggaaccgc agaauggcua      600

agcuuugacg uaacagacac aguaagagaa uggcuauuaa ggagagaauc aaaccuagga      660

cucgaaauaa guauacacug cccaugccac acauuccaac caaacggaga cauacuagaa      720

aacauacacg aaguuaugga aauaaaauuc aaaggagucg acaaugaaga ugaucacgga      780

aggggagacc uaggaagauu aaaaaaacaa aaagaccacc auaacccuca ucuaauauua      840

augaugauac caccucacag auuagauaac ccaggacaag gaggccaacg caaaaaaaga      900

gcacucgaua caaacuauug cuucagaaac cuagaagaaa acugcugcgu acgaccauua      960

uauauagacu uuagacaaga ccuaggaugg aaauggguac acgaaccaaa aggauacuau     1020

gcaaacuucu guucuggacc cugccccuac cucagaucag cagacacaac acauucaaca     1080

guacuaggcu uauacaacac auuaaauccc gaagcaucug caucaccaug cugcguccca     1140

caagacuuag aaccauuaac cauacuauac uacguaggac gaacaccaaa aguagaacaa     1200

uuaucaaaca uggucguaaa aucaugcaag ugcuccuaa                            1239


<210>  4809
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TGFbeta3__Homo_sapiens__P10600

<400>  4809

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  4810
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TGFbeta3__Homo_sapiens__AAC79727

<400>  4810
augaagaugc acuugcaaag ggcucuggug guccuggccc ugcugaacuu ugccacgguc       60

agccucucuc uguccacuug caccaccuug gacuucggcc acaucaagaa gaagagggug      120

gaagccauua ggggacagau cuugagcaag cucaggcuca ccagcccccc ugagccaacg      180

gugaugaccc acguccccua ucagguccug gcccuuuaca acagcacccg ggagcugcug      240

gaggagaugc auggggagag ggaggaaggc ugcacccagg aaaacaccga gucggaauac      300

uaugccaaag aaauccauaa auucgacaug auccaggggc uggcggagca caacgaacug      360

gcugucugcc cuaaaggaau uaccuccaag guuuuccgcu ucaauguguc cucaguggag      420

aaaaauagaa ccaaccuauu ccgagcagaa uuccgggucu ugcgggugcc caaccccagc      480

ucuaagcgga augagcagag gaucgagcuc uuccagaucc uucggccaga ugagcacauu      540

gccaaacagc gcuauaucgg uggcaagaau cugcccacac ggggcacugc cgaguggcug      600

uccuuugaug ucacugacac ugugcgugag uggcuguuga gaagagaguc caacuuaggu      660

cuagaaauca gcauucacug uccaugucac accuuucagc ccaauggaga uauccuggaa      720

aacauucacg aggugaugga aaucaaauuc aaaggcgugg acaaugagga ugaccauggc      780

cguggagauc uggggcgccu caagaagcag aaggaucacc acaacccuca ucuaauccuc      840

augaugauuc ccccacaccg gcucgacaac ccgggccagg ggggucagag gaagaagcgg      900

gcuuuggaca ccaauuacug cuuccgcaac uuggaggaga acugcugugu gcgcccccuc      960

uacauugacu uccgacagga ucugggcugg aagugggucc augaaccuaa gggcuacuau     1020

gccaacuucu gcucaggccc uugcccauac cuccgcagug cagacacaac ccacagcacg     1080

gugcugggac uguacaacac ucugaacccu gaagcaucug ccucgccuug cugcgugccc     1140

caggaccugg agccccugac cauccuguac uauguuggga ggacccccaa aguggagcag     1200

cucuccaaca ugguggugaa gucuuguaaa uguagcuga                            1239


<210>  4811
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4811
augaagaugc accuccagcg cgcccucgug gugcuggccc ugcucaacuu cgcgaccgug       60

agccuguccc ugagcacgug caccacccuc gacuucggcc acaucaagaa gaagcgggug      120

gaggccaucc gcgggcagau ccuguccaag cugcggcuca ccagcccgcc cgagcccacc      180

gucaugacgc acgugcccua ccaggugcug gcccuguaca acuccacccg cgagcuccug      240

gaggagaugc acggcgagcg ggaggagggg ugcacccagg agaacaccga gagcgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc uggccgagca caacgagcuc      360

gcggucugcc ccaaggggau cacguccaag guguuccgcu ucaacgugag cuccgucgag      420

aagaaccgga ccaaccuguu ccgcgccgag uuccgggugc ugcgcgugcc gaaccccagc      480

uccaagcgga acgagcagcg caucgagcug uuccagaucc ugcggcccga cgagcacauc      540

gccaagcagc gcuacaucgg cggcaagaac cugcccaccc gggggaccgc cgaguggcuc      600

agcuucgacg ucacggacac cgugcgcgag uggcugcugc ggcgcgaguc caaccucggc      660

cuggagauca gcauccacug cccgugccac accuuccagc ccaacgggga cauccuggag      720

aacauccacg aggugaugga gaucaaguuc aagggcgucg acaacgagga cgaccacggg      780

cggggcgacc ucggccgccu gaagaagcag aaggaccacc acaaccccca ccugauccuc      840

augaugaucc cgccccaccg gcuggacaac cccgggcagg gcgggcagcg caagaagcgc      900

gcgcuggaca ccaacuacug cuuccggaac cucgaggaga acugcugcgu gcgcccccug      960

uacaucgacu uccggcagga ccugggcugg aagugggugc acgagcccaa gggcuacuac     1020

gccaacuucu gcuccgggcc gugccccuac cuccgcagcg ccgacacgac ccacuccacc     1080

guccugggcc uguacaacac ccucaacccc gaggccagcg ccucccccug cugcgugccg     1140

caggaccugg agccccugac gauccucuac uacguggggc ggacccccaa ggucgagcag     1200

cugagcaaca ugguggucaa gagcugcaag ugcuccuga                            1239


<210>  4812
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4812
augaagaugc accuccagcg cgcccucguc guccucgccc uccucaacuu cgccaccguc       60

ucccucuccc ucuccaccug caccacccuc gacuucggcc acaucaagaa gaagcgcguc      120

gaggccaucc gcggccagau ccucuccaag cuccgccuca ccuccccccc cgagcccacc      180

gucaugaccc acguccccua ccagguccuc gcccucuaca acuccacccg cgagcuccuc      240

gaggagaugc acggcgagcg cgaggagggc ugcacccagg agaacaccga guccgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc ucgccgagca caacgagcuc      360

gccgucugcc ccaagggcau caccuccaag gucuuccgcu ucaacgucuc cuccgucgag      420

aagaaccgca ccaaccucuu ccgcgccgag uuccgcgucc uccgcguccc caaccccucc      480

uccaagcgca acgagcagcg caucgagcuc uuccagaucc uccgccccga cgagcacauc      540

gccaagcagc gcuacaucgg cggcaagaac cuccccaccc gcggcaccgc cgaguggcuc      600

uccuucgacg ucaccgacac cguccgcgag uggcuccucc gccgcgaguc caaccucggc      660

cucgagaucu ccauccacug ccccugccac accuuccagc ccaacggcga cauccucgag      720

aacauccacg aggucaugga gaucaaguuc aagggcgucg acaacgagga cgaccacggc      780

cgcggcgacc ucggccgccu caagaagcag aaggaccacc acaaccccca ccucauccuc      840

augaugaucc ccccccaccg ccucgacaac cccggccagg gcggccagcg caagaagcgc      900

gcccucgaca ccaacuacug cuuccgcaac cucgaggaga acugcugcgu ccgcccccuc      960

uacaucgacu uccgccagga ccucggcugg aagugggucc acgagcccaa gggcuacuac     1020

gccaacuucu gcuccggccc cugccccuac cuccgcuccg ccgacaccac ccacuccacc     1080

guccucggcc ucuacaacac ccucaacccc gaggccuccg ccucccccug cugcgucccc     1140

caggaccucg agccccucac cauccucuac uacgucggcc gcacccccaa ggucgagcag     1200

cucuccaaca uggucgucaa guccugcaag ugcuccuga                            1239


<210>  4813
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4813
augaagaugc aucugcagag agcccucgug guccuugcuc uguugaacuu cgcaaccguu       60

agcuuauccc ugucuacaug cacuacgcua gacuuuggcc acaucaaaaa gaaaagggug      120

gaggccauuc gggggcaaau acucucaaag cugcgccuua ccaguccccc ugaaccaaca      180

guaaugacuc acgugccgua ccagguccug gcguuguaua auagcacccg agagcuccug      240

gaagagaugc auggagaacg ugaggagggu uguacacagg aaaacaccga guccgaauac      300

uaugcuaaag agauccacaa guucgauaug auucagggcc uggccgagca uaaugaacuc      360

gcagugugcc ccaaggggau cacuucuaaa guuuuuagau ucaacguguc gucagucgag      420

aagaauagga caaacuuauu ucgggccgag uuccgcgugc ugagaguacc uaauccaagc      480

aguaaaagga acgaacaacg gauugaacuu uuucagaucu ugcgccccga cgagcacaua      540

gcuaagcagc gauacaucgg aggcaaaaau cugccuacca gagguacggc agaguggcua      600

uccuucgaug uuacugacac cgugagggaa uggcuccugc ggcgugaguc uaaccuuggg      660

cuggaaauua gcauccacug uccaugccau acauuucagc ccaauggaga uauuuuggag      720

aacauccacg aagucaugga gauaaaguuc aagggcgugg acaaugagga ugaccauggc      780

cgcggggauc ucggaagacu gaaaaagcaa aaagaccacc acaacccuca uuuaauucug      840

augaugaucc caccgcacag gcucgauaau cccggucagg gcgggcagcg gaagaaacga      900

gcccuugaca cuaacuauug uuuucgcaac cuggaagaga auugcugugu gagaccuuug      960

uacauugauu ucaggcagga ccuaggaugg aagugggucc augaaccaaa aggcuauuac     1020

gcuaacuuuu gcuccggucc cuguccuuac cugcggucag ccgacaccac acacaguacc     1080

guucucgggc uguauaauac gcuuaaccca gaggcgagcg caucucccug cugugugccg     1140

caagaucugg aaccuuugac uauccucuac uauguaggac gcacacccaa gguggagcag     1200

cuguccaaua uggucgugaa gucaugcaaa ugcagcuga                            1239


<210>  4814
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4814
augaagaugc accugcagag agcccuggug gugcuggccc ugcugaacuu cgccaccgug       60

agccugagcc ugagcaccug caccacccug gacuucggcc acaucaagaa gaagagagug      120

gaggccauca gaggccagau ccugagcaag cugagacuga ccagcccccc cgagcccacc      180

gugaugaccc acgugcccua ccaggugcug gcccuguaca acagcaccag agagcugcug      240

gaggagaugc acggcgagag agaggagggc ugcacccagg agaacaccga gagcgaguac      300

uacgccaagg agauccacaa guucgacaug auccagggcc uggccgagca caacgagcug      360

gccgugugcc ccaagggcau caccagcaag guguucagau ucaacgugag cagcguggag      420

aagaacagaa ccaaccuguu cagagccgag uucagagugc ugagagugcc caaccccagc      480

agcaagagaa acgagcagag aaucgagcug uuccagaucc ugagacccga cgagcacauc      540

gccaagcaga gauacaucgg cggcaagaac cugcccacca gaggcaccgc cgaguggcug      600

agcuucgacg ugaccgacac cgugagagag uggcugcuga gaagagagag caaccugggc      660

cuggagauca gcauccacug ccccugccac accuuccagc ccaacggcga cauccuggag      720

aacauccacg aggugaugga gaucaaguuc aagggcgugg acaacgagga cgaccacggc      780

agaggcgacc ugggcagacu gaagaagcag aaggaccacc acaaccccca ccugauccug      840

augaugaucc ccccccacag acuggacaac cccggccagg gcggccagag aaagaagaga      900

gcccuggaca ccaacuacug cuucagaaac cuggaggaga acugcugcgu gagaccccug      960

uacaucgacu ucagacagga ccugggcugg aagugggugc acgagcccaa gggcuacuac     1020

gccaacuucu gcagcggccc cugccccuac cugagaagcg ccgacaccac ccacagcacc     1080

gugcugggcc uguacaacac ccugaacccc gaggccagcg ccagccccug cugcgugccc     1140

caggaccugg agccccugac cauccuguac uacgugggca gaacccccaa gguggagcag     1200

cugagcaaca ugguggugaa gagcugcaag ugcagcuga                            1239


<210>  4815
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4815
augaagaugc accuucagag agcccucgug guccuggcuc ugcugaacuu cgccaccguu       60

agccucuccc ugucuacaug cacgacccuu gacuuuggcc auaucaaaaa gaaacgggug      120

gaggcgauuc gcgggcaaau ccugagcaag cucagacuga caucuccccc ugaaccgacc      180

gugaugacac acguccccua ccaggugcug gcucucuaua auuccacccg ggagcugcuu      240

gaagagaugc auggagaacg cgaggagggc uguacacagg aaaacaccga gagcgaauac      300

uaugccaaag agauucacaa guucgauaug auccaggggc uggccgagca uaaugaacuc      360

gcuguuugcc cuaagggaau uacguccaaa guguuuagau ucaacgucuc uagcguggag      420

aagaaucgga ccaaccuguu ucgcgccgag uucagaguuc uucgggugcc caauccuucc      480

agcaaacgca acgaacaaag aaucgaacug uuucagaucc uccggcccga cgagcacauu      540

gcuaagcagc gcuacaucgg cgggaaaaau cugccuacaa gaggaaccgc cgaguggcug      600

ucuuucgaug ucacagacac cgugcgggaa uggcuccugc gcagagaguc caaccuuggc      660

cuggaaauua gcauccacug uccgugccau acguuucagc ccaauggcga uauucucgag      720

aacauccacg aagugaugga gauuaaguuc aagggggucg acaaugagga ugaccaugga      780

cggggcgauc uggggagacu uaaaaagcaa aaagaccacc acaacccuca ucugauccuc      840

augaugauuc ccccucaccg ccuggauaau cccggacagg gcgggcagcg gaagaaaaga      900

gcgcuggaca caaacuauug uuuucgcaac cucgaagaga auugcugugu ucggccgcug      960

uacaucgauu ucagacagga ccuuggaugg aagugggugc augaaccuaa aggcuauuac     1020

gccaacuuuu gcucuggccc cuguccuuac cugcgcuccg cugacaccac acacagcacc     1080

gugcucgggc uguauaauac ccuuaacccc gaggccucug cuucccccug cugugucccu     1140

caagaucugg aaccgcucac aauccuguac uaugugggac ggacgcccaa gguugagcag     1200

cugagcaaua ugguggucaa guccugcaaa ugcucuuga                            1239


<210>  4816
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TGFbeta3__Homo_sapiens__AAC79727

<400>  4816
augaaaaugc accuacaacg agcacuagua guauuagcau uacuaaauuu cgcaaccgua       60

agccuaucau uaucaacuug cacaacacua gauuucggac auaucaaaaa aaaacgugua      120

gaagcgauuc gaggacaaau acuauccaaa cuacgacuaa caaguccacc agaaccaaca      180

guaaugacac acguaccaua ccaaguacua gcauuauaca acucaaccag ggaacuacua      240

gaagaaaugc acggagaaag agaagaagga ugcacacaag aaaacacaga aucagaauac      300

uacgccaaag aaauacacaa auuugacaug auccaaggau uagcagaaca caacgaauua      360

gcugucugcc ccaaaggaau aacaucaaaa gucuuuagau uuaauguaag cagcguugaa      420

aaaaacagaa caaaccuauu ccgagcagaa uuuagaguac uaaggguacc aaaccccagu      480

ucaaaaagaa augaacaaag aauagaacua uuucaaauau uacgaccaga ugaacacaua      540

gcaaaacaaa gauacauagg cggaaaaaac cuaccaacaa gaggaacagc agaauggcua      600

ucauuugacg uaacagacac uguacgagaa ugguuacuaa gaagagaauc aaacuuagga      660

cuagaaauaa gcauacacug cccaugucac accuuccaac cgaacggaga cauauuagaa      720

aacauacacg aaguaaugga aauaaaauuc aaaggaguag acaaugaaga ugaccaugga      780

agaggagacu uagggagauu aaaaaaacaa aaagaccauc acaacccaca uuuaauacua      840

augaugaucc caccacacag acuagacaac cccggacaag gaggacaaag aaaaaaaaga      900

gcccuagaua caaauuacug cuuuagaaac cuagaagaaa acuguugcgu acgaccauua      960

uacauagacu ucagacaaga cuuaggaugg aaauggguac acgaaccuaa aggauacuac     1020

gcaaacuuuu gcagcggacc augcccauac cuuagaucag cugacacaac ccacuccaca     1080

gucuuaggac uauauaacac auuaaaucca gaagcaucag caucaccaug uuguguacca     1140

caagaccuag aaccgcuaac aauacucuau uacguaggaa gaacaccaaa aguagaacaa     1200

cuaaguaaca uggugguaaa aucaugcaaa uguucauaa                            1239


<210>  4817
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TL1A__Homo_sapiens__O95150

<400>  4817

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  4818
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TL1A__Homo_sapiens__AAH69435

<400>  4818
auggccgagg aucugggacu gagcuuuggg gaaacagcca guguggaaau gcugccagag       60

cacggcagcu gcaggcccaa ggccaggagc agcagcgcac gcugggcucu caccugcugc      120

cugguguugc uccccuuccu ugcaggacuc accacauacc ugcuugucag ccagcuccgg      180

gcccagggag aggccugugu gcaguuccag gcucuaaaag gacaggaguu ugcaccuuca      240

caucagcaag uuuaugcacc ucuuagagca gacggagaua agccaagggc acaccugaca      300

guugugagac aaacucccac acagcacuuu aaaaaucagu ucccagcucu gcacugggaa      360

caugaacuag gccuggccuu caccaagaac cgaaugaacu auaccaacaa auuccugcug      420

aucccagagu cgggagacua cuucauuuac ucccagguca cauuccgugg gaugaccucu      480

gagugcagug aaaucagaca agcaggccga ccaaacaagc cagacuccau cacugugguc      540

aucaccaagg uaacagacag cuacccugag ccaacccagc uccucauggg gaccaagucu      600

gugugcgaag uagguagcaa cugguuccag cccaucuacc ucggagccau guucuccuug      660

caagaagggg acaagcuaau ggugaacguc agugacaucu cuuuggugga uuacacaaaa      720

gaagauaaaa ccuucuuugg agccuucuua cuauag                                756


<210>  4819
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TL1A__Homo_sapiens__AAH69435

<400>  4819
auggccgagg accugggccu cagcuucggg gagaccgccu ccguggagau gcugcccgag       60

cacggcagcu gccgcccgaa ggcgcggucc agcuccgccc gcugggcccu gaccugcugc      120

cucguccugc ugcccuuccu cgccgggcug acgaccuacc ugcucgugag ccagcugcgg      180

gcccagggcg aggcgugcgu gcaguuccag gcccugaagg ggcaggaguu cgcccccucc      240

caccagcagg ucuacgcgcc ccuccgcgcc gacggcgaca agccgcgggc ccaccugacc      300

guggugcgcc agacccccac gcagcacuuc aagaaccagu uccccgcccu gcacugggag      360

cacgagcucg gccuggccuu caccaagaac cggaugaacu acaccaacaa guuccugcuc      420

auccccgaga gcggggacua cuucaucuac ucccagguca ccuuccgcgg caugacgagc      480

gagugcuccg agauccggca ggccgggcgc ccgaacaagc ccgacagcau caccguggug      540

aucaccaagg ucaccgacuc cuaccccgag cccacgcagc ugcugauggg caccaagagc      600

gugugcgagg ugggguccaa cugguuccag ccgaucuacc ucggcgcgau guucagccug      660

caggagggcg acaagcugau ggucaacgug uccgacauca gccucgugga cuacaccaag      720

gaggacaaga ccuucuucgg ggccuuccug cuguga                                756


<210>  4820
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TL1A__Homo_sapiens__AAH69435

<400>  4820
auggccgagg accucggccu cuccuucggc gagaccgccu ccgucgagau gcuccccgag       60

cacggcuccu gccgccccaa ggcccgcucc uccuccgccc gcugggcccu caccugcugc      120

cucguccucc uccccuuccu cgccggccuc accaccuacc uccucgucuc ccagcuccgc      180

gcccagggcg aggccugcgu ccaguuccag gcccucaagg gccaggaguu cgcccccucc      240

caccagcagg ucuacgcccc ccuccgcgcc gacggcgaca agccccgcgc ccaccucacc      300

gucguccgcc agacccccac ccagcacuuc aagaaccagu uccccgcccu ccacugggag      360

cacgagcucg gccucgccuu caccaagaac cgcaugaacu acaccaacaa guuccuccuc      420

auccccgagu ccggcgacua cuucaucuac ucccagguca ccuuccgcgg caugaccucc      480

gagugcuccg agauccgcca ggccggccgc cccaacaagc ccgacuccau caccgucguc      540

aucaccaagg ucaccgacuc cuaccccgag cccacccagc uccucauggg caccaagucc      600

gucugcgagg ucggcuccaa cugguuccag cccaucuacc ucggcgccau guucucccuc      660

caggagggcg acaagcucau ggucaacguc uccgacaucu cccucgucga cuacaccaag      720

gaggacaaga ccuucuucgg cgccuuccuc cucuga                                756


<210>  4821
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TL1A__Homo_sapiens__AAH69435

<400>  4821
auggccgagg accugggccu cagcuucggg gaaaccgcuu ccguggagau gcuucccgaa       60

cacggaucuu gcagaccuaa ggcaagguca aguagcgccc ggugggcgcu gacauguugc      120

uuggucuuac ugccauuucu agcuggucuc acuacguacc ugcuuguuuc ccagcugcgc      180

gcccaaggcg aggcaugugu gcaguuccag gccuugaaag ggcaggaauu ugcuccgucu      240

caucaacagg uauaugcacc ccuccgagcc gauggagaca agccucgugc ucaccugacc      300

guggucagac agacaccaac ucagcauuuc aaaaaccaau uucccgcccu gcacugggag      360

caugagcucg gcuuagcguu caccaagaau aggaugaacu acacaaauaa auuucugcuu      420

aucccugaau cgggugauua uuucauuuac ucacagguga ccuuucgggg gaugacuagc      480

gagugcagug aaauacgcca ggcaggaaga ccaaacaagc ccgacuccau cacaguugug      540

auuaccaagg ucacggauuc uuauccugag ccaacucagu ugcugauggg caccaaaagc      600

gugugugagg uaggcuccaa uugguuccaa ccgaucuacc uaggggccau guuuucacuc      660

caggaaggag acaagcugau gguuaacgug agugauauua gccuugucga cuauacaaaa      720

gaggauaaga cuuucuuugg ugcuuuccug uuguga                                756


<210>  4822
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TL1A__Homo_sapiens__AAH69435

<400>  4822
auggccgagg accugggccu gagcuucggc gagaccgcca gcguggagau gcugcccgag       60

cacggcagcu gcagacccaa ggccagaagc agcagcgcca gaugggcccu gaccugcugc      120

cuggugcugc ugcccuuccu ggccggccug accaccuacc ugcuggugag ccagcugaga      180

gcccagggcg aggccugcgu gcaguuccag gcccugaagg gccaggaguu cgcccccagc      240

caccagcagg uguacgcccc ccugagagcc gacggcgaca agcccagagc ccaccugacc      300

guggugagac agacccccac ccagcacuuc aagaaccagu uccccgcccu gcacugggag      360

cacgagcugg gccuggccuu caccaagaac agaaugaacu acaccaacaa guuccugcug      420

auccccgaga gcggcgacua cuucaucuac agccagguga ccuucagagg caugaccagc      480

gagugcagcg agaucagaca ggccggcaga cccaacaagc ccgacagcau caccguggug      540

aucaccaagg ugaccgacag cuaccccgag cccacccagc ugcugauggg caccaagagc      600

gugugcgagg ugggcagcaa cugguuccag cccaucuacc ugggcgccau guucagccug      660

caggagggcg acaagcugau ggugaacgug agcgacauca gccuggugga cuacaccaag      720

gaggacaaga ccuucuucgg cgccuuccug cuguga                                756


<210>  4823
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TL1A__Homo_sapiens__AAH69435

<400>  4823
auggccgagg accugggccu cagcuucggg gaaaccgcuu ccguggagau gcugcccgaa       60

cacggaucuu gcagaccuaa ggcccggagc uccucugcgc gcugggcucu uacauguugc      120

cugguccucc ugccguuucu ugccggccug acgaccuacc uccugguuag ccagcugaga      180

gcccaagggg aggcuugugu gcaguuccag gcccucaaag gacaggaauu ugcucccucc      240

caucaacagg uguaugcccc ucugcgggcg gauggcgaca agccccgcgc ccaccuuaca      300

gucgugagac agaccccuac acagcauuuc aaaaaccaau uucccgcucu gcacugggag      360

caugagcucg ggcuggccuu caccaagaau cggaugaacu acacaaauaa auuucuucug      420

aucccugaau cuggagauua uuucauuuac agccagguua ccuuucgcgg caugacgucc      480

gagugcagcg aaaucagaca ggcuggccgg ccgaacaagc ccgacucuau uaccgugguc      540

aucacaaagg ugaccgauuc cuauccugag cccacacagc uccugauggg gaccaaaagc      600

guuugugagg ugggaucuaa uugguuccaa ccuauuuacc ugggcgccau guuuucccuc      660

caggaagggg acaagcugau ggucaacgug agcgauaucu cucuugugga cuauacgaaa      720

gaggauaaga cauucuuugg agcguuccug cucuga                                756


<210>  4824
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TL1A__Homo_sapiens__AAH69435

<400>  4824
auggcagaag accuaggacu aucauucgga gaaacagcau caguagaaau gcuacccgaa       60

cacgguucau gcagaccaaa agcaagauca ucauccgcaa gaugggcacu aacaugcugc      120

cuaguacuac uuccauuccu agcaggauua acaacauacc uauuagucag ccaacuacga      180

gcacaaggag aagcaugcgu acaauuccaa gcacuaaaag gacaagaauu cgcucccuca      240

caccaacaag uauacgcacc acuaagagca gacggagaca aaccaagagc acaucuaaca      300

guagucagac aaacaccuac acaacacuuc aaaaaucaau uccccgcucu acacugggaa      360

cacgaacuag gauuagcauu cacaaaaaau agaaugaacu acacaaacaa auuccuauua      420

auaccagaau caggcgacua cuuuauauac ucacaaguaa cuuucagagg aaugacauca      480

gaaugcucag aaauaagaca agcaggaaga ccaaacaaac cagacuccau aacaguagua      540

auaacaaaag uaacagacuc auaccccgaa ccuacucaau uacuaauggg aacaaaauca      600

guaugcgaag uaggcucaaa cugguuccaa ccaauauacu uaggagcuau guucaguuua      660

caagaaggag auaaauuaau gguaaacguu uccgacauau cacuaguaga cuacacaaaa      720

gaagauaaaa cauucuucgg agcauucuua cuauaa                                756


<210>  4825
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TWEAK__Homo_sapiens__Q4ACW9

<400>  4825

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  4826
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TWEAK__Homo_sapiens__AAI04421

<400>  4826
auggccgccc gucggagcca gaggcggagg gggcgccggg gggagccggg caccgcccug       60

cuggucccgc ucgcgcuggg ccugggccug gcgcuggccu gccucggccu ccugcuggcc      120

guggucaguu uggggagccg ggcaucgcug uccgcccagg agccugccca ggaggagcug      180

guggcagagg aggaccagga cccgucggaa cugaaucccc agacagaaga aagccaggau      240

ccugcgccuu uccugaaccg acuaguucgg ccucgcagaa gugcaccuaa aggccggaaa      300

acacgggcuc gaagagcgau cgcagcccau uaugaaguuc auccacgacc uggacaggac      360

ggagcgcagg caggugugga cgggacagug aguggcuggg aggaagccag aaucaacagc      420

uccagcccuc ugcgcuacaa ccgccagauc ggggaguuua uagucacccg ggcugggcuc      480

uacuaccugu acugucaggu gcacuuugau gaggggaagg cugucuaccu gaagcuggac      540

uugcuggugg auggugugcu ggcccugcgc ugccuggagg aauucucagc cacugcggcg      600

aguucccucg ggccccagcu ccgccucugc caggugucug ggcuguuggc ccugcggcca      660

ggguccuccc ugcggauccg cacccucccc ugggcccauc ucaaggcugc ccccuuccuc      720

accuacuucg gacucuucca gguucacuga                                       750


<210>  4827
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4827
auggccgccc gccggagcca gcgccggcgc gggcggcgcg gggagcccgg caccgcgcug       60

cucgugccgc uggcccuggg gcucggccug gcccuggccu gccucgggcu gcugcucgcc      120

gucguguccc ugggcagccg ggcgucccug agcgcccagg agcccgccca ggaggagcuc      180

guggccgagg aggaccagga ccccuccgag cugaaccccc agaccgagga gagccaggac      240

ccggcgcccu uccugaaccg ccucguccgg ccccgccggu ccgcccccaa gggccgcaag      300

acgcgggccc gccgggccau cgccgcgcac uacgaggugc acccgcgccc cgggcaggac      360

ggcgcccagg ccggggugga cggcaccguc agcggguggg aggaggcccg gaucaacucc      420

agcagccccc ugcgcuacaa ccggcagauc ggcgaguuca ucgugacccg cgccggccug      480

uacuaccucu acugccaggu gcacuucgac gaggggaagg cggucuaccu gaagcuggac      540

cuccuggugg acggcgugcu ggcccuccgg ugccuggagg aguucuccgc caccgccgcc      600

uccagccugg ggccccagcu ccgccugugc caggucuccg gccugcucgc gcugcgcccg      660

ggcagcuccc ugcggauccg cacgcucccc ugggcccacc ugaaggccgc ccccuuccug      720

accuacuucg gccucuucca ggugcacuga                                       750


<210>  4828
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4828
auggccgccc gccgcuccca gcgccgccgc ggccgccgcg gcgagcccgg caccgcccuc       60

cucguccccc ucgcccucgg ccucggccuc gcccucgccu gccucggccu ccuccucgcc      120

gucgucuccc ucggcucccg cgccucccuc uccgcccagg agcccgccca ggaggagcuc      180

gucgccgagg aggaccagga ccccuccgag cucaaccccc agaccgagga gucccaggac      240

cccgcccccu uccucaaccg ccucguccgc ccccgccgcu ccgcccccaa gggccgcaag      300

acccgcgccc gccgcgccau cgccgcccac uacgaggucc acccccgccc cggccaggac      360

ggcgcccagg ccggcgucga cggcaccguc uccggcuggg aggaggcccg caucaacucc      420

uccucccccc uccgcuacaa ccgccagauc ggcgaguuca ucgucacccg cgccggccuc      480

uacuaccucu acugccaggu ccacuucgac gagggcaagg ccgucuaccu caagcucgac      540

cuccucgucg acggcguccu cgcccuccgc ugccucgagg aguucuccgc caccgccgcc      600

uccucccucg gcccccagcu ccgccucugc caggucuccg gccuccucgc ccuccgcccc      660

ggcuccuccc uccgcauccg cacccucccc ugggcccacc ucaaggccgc ccccuuccuc      720

accuacuucg gccucuucca gguccacuga                                       750


<210>  4829
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4829
auggccgcua gaaggagcca gcggcgccga ggccguagag gggagcccgg aaccgcacug       60

cucgugccuc uugcccuggg uuugggcuua gcgcuggcuu gccuagggcu ccugcuugcc      120

gucguuuccc ugggaucuag ggcaucauug agugcccaag aaccagcuca ggaggaacuc      180

guggcagagg aagaccagga uccgagcgag cugaaccccc agacagagga aucccaagac      240

ccugccccau uccugaaucg gcucguacgc cccagaaggu cugcuccuaa gggccggaaa      300

acucgcgcca gacgagcgau cgcagcccac uacgaggugc auccaaggcc cggucaggau      360

ggggcucagg ccggagucga cggcacggug ucgggcuggg aagaggcacg gauuaacuca      420

agcaguccuu uacguuauaa ucgccagaua ggggaguuua ucguuaccag agcuggacug      480

uacuaucuuu acugucaagu gcacuucgau gaagguaagg ccgucuauuu gaaacuggac      540

cuacucgugg auggcguacu ggcgcuuagg ugccuggagg aauuuuccgc cacagcagcu      600

ucuagcuugg ggccacagcu ccggcugugu cagguuuccg gauuacuggc ccuccgaccg      660

ggcucaaguc uucgcauuag aacucugccc ugggcucauu ugaaggccgc accuuuccua      720

accuacuuug gucuguucca ggugcacuga                                       750


<210>  4830
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4830
auggccgcca gaagaagcca gagaagaaga ggcagaagag gcgagcccgg caccgcccug       60

cuggugcccc uggcccuggg ccugggccug gcccuggccu gccugggccu gcugcuggcc      120

guggugagcc ugggcagcag agccagccug agcgcccagg agcccgccca ggaggagcug      180

guggccgagg aggaccagga ccccagcgag cugaaccccc agaccgagga gagccaggac      240

cccgcccccu uccugaacag acuggugaga cccagaagaa gcgcccccaa gggcagaaag      300

accagagcca gaagagccau cgccgcccac uacgaggugc accccagacc cggccaggac      360

ggcgcccagg ccggcgugga cggcaccgug agcggcuggg aggaggccag aaucaacagc      420

agcagccccc ugagauacaa cagacagauc ggcgaguuca ucgugaccag agccggccug      480

uacuaccugu acugccaggu gcacuucgac gagggcaagg ccguguaccu gaagcuggac      540

cugcuggugg acggcgugcu ggcccugaga ugccuggagg aguucagcgc caccgccgcc      600

agcagccugg gcccccagcu gagacugugc caggugagcg gccugcuggc ccugagaccc      660

ggcagcagcc ugagaaucag aacccugccc ugggcccacc ugaaggccgc ccccuuccug      720

accuacuucg gccuguucca ggugcacuga                                       750


<210>  4831
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4831
auggccgcua gacggagcca gcgcagacgg ggccgcagag gggagcccgg aaccgcccug       60

cucgugccuc uggcgcuugg ccuggggcuc gcucuggccu gccuuggacu gcuccuggcc      120

gucguuuccc ugggcucucg ggcuagccuc uccgcccaag aaccggcuca ggaggaacug      180

guggccgagg aagaccagga ucccucugag cuuaacccuc agacagagga aagccaagac      240

cccgcgccuu uccugaaucg ccucgugaga ccccggcgcu ccgccccuaa ggggagaaaa      300

acgcgggcuc gcagagccau cgcugcccac uacgaggucc auccgcggcc cggacaggau      360

ggcgcgcagg ccggcgugga cgggaccguu ucuggauggg aagaggcucg cauuaacagc      420

uccagcccuc ugagauauaa ucggcagauc ggcgaguuua uugugacaag agccgggcuu      480

uacuaucugu acugucaagu ccacuucgau gaaggaaagg cuguguaucu caaacuggac      540

cugcucguug auggcgugcu ggcccuucgc ugccuggagg aauuuucugc caccgcugcg      600

uccagccucg ggccccagcu gcggcuuugu caggucucug gacugcucgc ccugagaccu      660

ggcuccagcc ugcgcauccg gacacucccc ugggcucauc ugaaggccgc cccguuccuu      720

accuacuuug gccuguucca ggugcacuga                                       750


<210>  4832
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TWEAK__Homo_sapiens__AAI04421

<400>  4832
auggcagcca gaagaucaca aagaagaaga ggaagaagag gagaaccagg uacagcacuu       60

uuaguaccau uagcauuagg auuaggauua gcauuggcuu gccuaggacu auuacuagca      120

gucguaaguu uaggaucaag agcaagcuua agugcacaag aaccagcuca agaagaauua      180

guagcagaag aagaccaaga cccaagcgaa cuaaauccac aaacagaaga aucgcaagau      240

ccagcgccau uuuuaaauag acuagucagg ccacgaagau cugcaccuaa aggaagaaaa      300

acaagagcaa gaagagcaau agcagcacau uaugaaguac acccaagacc aggacaagau      360

ggcgcucaag cagguguaga uggaacagua aguggauggg aagaagcaag aauaaacuca      420

aguucaccau ugagauauaa cagacaaauu ggagaauuca uaguaacaag agcuggauua      480

uauuaucuau auugccaagu acauuucgau gaaggaaaag cugucuaucu aaaacuagau      540

cuauuaguug auggcguauu agcuuuaagg ugcuuagaag aauucucagc aacugcagca      600

ucaucauuag gaccacaauu aagauuaugu caaguaagcg gacuauuagc auuaagacca      660

ggcucaaguc uaagaauaag aacacuacca ugggcacauu uaaaagcagc accauucuua      720

acauauuuug guuuauuuca aguacacuaa                                       750


<210>  4833
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL11__Homo_sapiens__P51671

<400>  4833

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  4834
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL11__Homo_sapiens__AAA98957

<400>  4834
augaaggucu ccgcagcacu ucuguggcug cugcucauag cagcugccuu cagcccccag       60

gggcucgcug ggccagcuuc ugucccaacc accugcugcu uuaaccuggc caauaggaag      120

auaccccuuc agcgacuaga gagcuacagg agaaucacca guggcaaaug uccccagaaa      180

gcugugaucu ucaagaccaa acuggccaag gauaucugug ccgaccccaa gaagaagugg      240

gugcaggauu ccaugaagua ucuggaccaa aaaucuccaa cuccaaagcc auaa            294


<210>  4835
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL11__Homo_sapiens__AAA98957

<400>  4835
augaagguga gcgccgcccu gcucuggcug cugcucaucg cggccgccuu cagcccccag       60

ggccuggccg ggccggccag cguccccacg accugcugcu ucaaccuggc gaaccgcaag      120

aucccccucc agcggcugga guccuaccgc cggaucacca gcggcaagug cccccagaag      180

gccgugaucu ucaagaccaa gcuggccaag gacaucugcg ccgacccgaa gaagaagugg      240

gugcaggacu ccaugaagua ccucgaccag aaguccccca cccccaagcc cuga            294


<210>  4836
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL11__Homo_sapiens__AAA98957

<400>  4836
augaaggucu ccgccgcccu ccucuggcuc cuccucaucg ccgccgccuu cuccccccag       60

ggccucgccg gccccgccuc cguccccacc accugcugcu ucaaccucgc caaccgcaag      120

aucccccucc agcgccucga guccuaccgc cgcaucaccu ccggcaagug cccccagaag      180

gccgucaucu ucaagaccaa gcucgccaag gacaucugcg ccgaccccaa gaagaagugg      240

guccaggacu ccaugaagua ccucgaccag aaguccccca cccccaagcc cuga            294


<210>  4837
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL11__Homo_sapiens__AAA98957

<400>  4837
augaagguga gcgccgcucu gcucuggcuu cuguugaucg cagccgcguu caguccccag       60

ggcuuagcug ggccugccuc ugucccaacc acaugcuguu uuaaccuggc aaauagaaaa      120

auuccgcuac aaaggcucga gucauaccgg cgcauaacuu ccggaaagug cccccagaaa      180

gccguuaucu ucaagacgaa acuggcuaag gacauuugug cagauccuaa gaaaaagugg      240

gugcaggaca gcaugaaaua ucuugaucag aaguccccaa cccccaaacc uuga            294


<210>  4838
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL11__Homo_sapiens__AAA98957

<400>  4838
augaagguga gcgccgcccu gcuguggcug cugcugaucg ccgccgccuu cagcccccag       60

ggccuggccg gccccgccag cgugcccacc accugcugcu ucaaccuggc caacagaaag      120

aucccccugc agagacugga gagcuacaga agaaucacca gcggcaagug cccccagaag      180

gccgugaucu ucaagaccaa gcuggccaag gacaucugcg ccgaccccaa gaagaagugg      240

gugcaggaca gcaugaagua ccuggaccag aagagcccca cccccaagcc cuga            294


<210>  4839
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL11__Homo_sapiens__AAA98957

<400>  4839
augaagguga gcgccgcucu gcucuggcug cuucugaucg ccgcggcuuu cagcccccag       60

ggccucgccg ggccugccuc ugucccgacc acaugcuguu uuaaccuggc uaauagaaaa      120

auuccccuuc aacggcugga gagcuaccgc agaaucacgu ccggaaagug cccucagaaa      180

gccguuauuu ucaagaccaa acucgcuaag gacaucugug ccgaucccaa gaaaaagugg      240

gugcaggacu cuaugaaaua ucuggaucag aaguccccua cacccaaacc uuga            294


<210>  4840
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL11__Homo_sapiens__AAA98957

<400>  4840
augaaaguau cagcagcacu acuauggcua cuacuaauag cagcagcauu cucaccacaa       60

ggacuagcag gaccagcauc aguaccaaca acaugcugcu ucaaccuagc aaacagaaaa      120

auaccacuac aaagacuaga aucauacaga agaauaacau caggaaaaug cccacaaaaa      180

gcaguaauau ucaaaacaaa acuagcaaaa gacauaugcg cagacccaaa aaaaaaaugg      240

guacaagacu caaugaaaua ccuagaccaa aaaucaccaa caccaaaacc auaa            294


<210>  4841
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL11__Homo_sapiens__Q6I9T4

<400>  4841

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  4842
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL11__Homo_sapiens__ABK41951

<400>  4842
augaaggucu ccgcagcacu ucuguggcug cugcucauag cagcugccuu cagcccccag       60

gggcucgcug ggccagcuuc ugucccaacc accugcugcu uuaaccuggc caauaggaag      120

auaccccuuc agcgacuaga gagcuacagg agaaucacca guggcaaaug uccccagaaa      180

gcugugaucu ucaagaccaa acuggccaag gauaucugug ccgaccccaa gaagaagugg      240

gugcaggauu ccaugaagua ucuggaccaa aaaucuccaa cuccaaagcc auaa            294


<210>  4843
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL11__Homo_sapiens__ABK41951

<400>  4843
augaagguga gcgccgcccu gcucuggcug cugcucaucg cggccgccuu cagcccccag       60

ggccuggccg ggccggccag cguccccacg accugcugcu ucaaccuggc gaaccgcaag      120

aucccccucc agcggcugga guccuaccgc cggaucacca gcggcaagug cccccagaag      180

gccgugaucu ucaagaccaa gcuggccaag gacaucugcg ccgacccgaa gaagaagugg      240

gugcaggacu ccaugaagua ccucgaccag aaguccccca cccccaagcc cuga            294


<210>  4844
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL11__Homo_sapiens__ABK41951

<400>  4844
augaaggucu ccgccgcccu ccucuggcuc cuccucaucg ccgccgccuu cuccccccag       60

ggccucgccg gccccgccuc cguccccacc accugcugcu ucaaccucgc caaccgcaag      120

aucccccucc agcgccucga guccuaccgc cgcaucaccu ccggcaagug cccccagaag      180

gccgucaucu ucaagaccaa gcucgccaag gacaucugcg ccgaccccaa gaagaagugg      240

guccaggacu ccaugaagua ccucgaccag aaguccccca cccccaagcc cuga            294


<210>  4845
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL11__Homo_sapiens__ABK41951

<400>  4845
augaagguga gcgccgcucu gcucuggcuu cuguugaucg cagccgcguu caguccccag       60

ggcuuagcug ggccugccuc ugucccaacc acaugcuguu uuaaccuggc aaauagaaaa      120

auuccgcuac aaaggcucga gucauaccgg cgcauaacuu ccggaaagug cccccagaaa      180

gccguuaucu ucaagacgaa acuggcuaag gacauuugug cagauccuaa gaaaaagugg      240

gugcaggaca gcaugaaaua ucuugaucag aaguccccaa cccccaaacc uuga            294


<210>  4846
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL11__Homo_sapiens__ABK41951

<400>  4846
augaagguga gcgccgcccu gcuguggcug cugcugaucg ccgccgccuu cagcccccag       60

ggccuggccg gccccgccag cgugcccacc accugcugcu ucaaccuggc caacagaaag      120

aucccccugc agagacugga gagcuacaga agaaucacca gcggcaagug cccccagaag      180

gccgugaucu ucaagaccaa gcuggccaag gacaucugcg ccgaccccaa gaagaagugg      240

gugcaggaca gcaugaagua ccuggaccag aagagcccca cccccaagcc cuga            294


<210>  4847
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL11__Homo_sapiens__ABK41951

<400>  4847
augaagguga gcgccgcucu gcucuggcug cuucugaucg ccgcggcuuu cagcccccag       60

ggccucgccg ggccugccuc ugucccgacc acaugcuguu uuaaccuggc uaauagaaaa      120

auuccccuuc aacggcugga gagcuaccgc agaaucacgu ccggaaagug cccucagaaa      180

gccguuauuu ucaagaccaa acucgcuaag gacaucugug ccgaucccaa gaaaaagugg      240

gugcaggacu cuaugaaaua ucuggaucag aaguccccua cacccaaacc uuga            294


<210>  4848
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL11__Homo_sapiens__ABK41951

<400>  4848
augaaaguau cagccgcacu acuauggcua cuacuaauag cagcagcauu cucaccacaa       60

ggacuagcag gaccagcauc aguaccaaca acaugcugcu ucaaccuagc aaacagaaaa      120

auaccauuac aaagacuaga aucauacaga agaauaacau caggaaaaug cccacaaaaa      180

gcaguaauau ucaaaacaaa acucgcaaaa gacauaugcg cagacccaaa aaaaaaaugg      240

guacaagacu caaugaaaua ccuagaccaa aaaucaccaa caccaaaacc auaa            294


<210>  4849
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL12__Mus_musculus__Q62401

<400>  4849

Met Lys Ile Ser Thr Leu Leu Cys Leu Leu Leu Ile Ala Thr Thr Ile 
1               5                   10                  15      


Ser Pro Gln Val Leu Ala Gly Pro Asp Ala Val Ser Thr Pro Val Thr 
            20                  25                  30          


Cys Cys Tyr Asn Val Val Lys Gln Lys Ile His Val Arg Lys Leu Lys 
        35                  40                  45              


Ser Tyr Arg Arg Ile Thr Ser Ser Gln Cys Pro Arg Glu Ala Val Ile 
    50                  55                  60                  


Phe Arg Thr Ile Leu Asp Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys 
65                  70                  75                  80  


Trp Val Lys Asn Ser Ile Asn His Leu Asp Lys Thr Ser Gln Thr Phe 
                85                  90                  95      


Ile Leu Glu Pro Ser Cys Leu Gly 
            100                 


<210>  4850
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL12__Mus_musculus__AAB49424

<400>  4850
augaagauuu ccacacuucu augccuccug cucauagcua ccaccaucag uccucaggua       60

uuggcuggac cagaugcggu gagcacccca gucacgugcu guuauaaugu uguuaagcag      120

aagauucacg uccggaagcu gaagagcuac aggagaauca caagcagcca guguccccgg      180

gaagcuguga ucuucaggac cauacuggau aaggagaucu gugcugaccc caaggagaag      240

uggguuaaga auuccauaaa ccacuuggau aagacgucuc aaaccuucau ccuugaaccu      300

ucaugucuag gcuga                                                       315


<210>  4851
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL12__Mus_musculus__AAB49424

<400>  4851
augaagauca gcacccugcu cugccugcug cucaucgcca ccacgaucag cccccaggug       60

cuggccggcc cggacgcggu cuccaccccc gugaccugcu gcuacaacgu ggucaagcag      120

aagauccacg ugcgcaagcu gaaguccuac cggcgcauca ccagcuccca gugcccccgg      180

gaggccguga ucuuccgcac gauccucgac aaggagaucu gcgccgaccc caaggagaag      240

ugggucaaga acagcaucaa ccaccuggac aagaccuccc agaccuucau ccuggagccg      300

agcugccucg gguga                                                       315


<210>  4852
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL12__Mus_musculus__AAB49424

<400>  4852
augaagaucu ccacccuccu cugccuccuc cucaucgcca ccaccaucuc cccccagguc       60

cucgccggcc ccgacgccgu cuccaccccc gucaccugcu gcuacaacgu cgucaagcag      120

aagauccacg uccgcaagcu caaguccuac cgccgcauca ccuccuccca gugcccccgc      180

gaggccguca ucuuccgcac cauccucgac aaggagaucu gcgccgaccc caaggagaag      240

ugggucaaga acuccaucaa ccaccucgac aagaccuccc agaccuucau ccucgagccc      300

uccugccucg gcuga                                                       315


<210>  4853
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL12__Mus_musculus__AAB49424

<400>  4853
augaagauca gcacccugcu cugccuucug uugauugcca caacuauauc uccccaggug       60

uuagcuggcc cugacgcagu cuccacgcca guuaccuguu gcuacaacgu gguaaaacaa      120

aagauccacg ugagaaaacu gaagucauau aggcggauua caaguagcca guguccgcgc      180

gaggccguca ucuuccgaac uauucuagau aaagaaaucu gcgcggaccc caaggagaag      240

ugggugaaaa auuccauaaa ccaucucgau aagaccucuc agacauuuau ccuggaaccu      300

ucgugucuug gguga                                                       315


<210>  4854
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL12__Mus_musculus__AAB49424

<400>  4854
augaagauca gcacccugcu gugccugcug cugaucgcca ccaccaucag cccccaggug       60

cuggccggcc ccgacgccgu gagcaccccc gugaccugcu gcuacaacgu ggugaagcag      120

aagauccacg ugagaaagcu gaagagcuac agaagaauca ccagcagcca gugccccaga      180

gaggccguga ucuucagaac cauccuggac aaggagaucu gcgccgaccc caaggagaag      240

ugggugaaga acagcaucaa ccaccuggac aagaccagcc agaccuucau ccuggagccc      300

agcugccugg gcuga                                                       315


<210>  4855
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL12__Mus_musculus__AAB49424

<400>  4855
augaagauca gcacccugcu cugccugcuu cugauugcca caacgaucag cccccaggug       60

cucgcuggcc cugacgccgu cucuaccccg guuacauguu gcuacaacgu ggugaaacaa      120

aagauucacg ucagaaaacu gaaguccuau cggcgcauca ccuccucuca gugucccaga      180

gaggcgguga uuuuccggac aauccuugau aaagaaaucu gcgcugaccc uaaggagaag      240

uggguuaaaa auagcauuaa ccaucuggau aagaccuccc agacauuuau ccucgaaccc      300

ucuugucugg gguga                                                       315


<210>  4856
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL12__Mus_musculus__AAB49424

<400>  4856
augaaaauaa gcacacuacu augccuacua cuaauagcaa caacaauauc accacaagua       60

cuagcaggac cagacgcagu aucaacacca guaacaugcu gcuacaacgu aguaaaacaa      120

aaaauacacg uaagaaaacu aaaaucauac agaagaauaa caucaucaca augcccaaga      180

gaagcaguaa uauucagaac aauacuagac aaagaaauau gcgcagaccc aaaagaaaaa      240

uggguaaaaa acucaauaaa ccaccuagac aaaacaucac aaacauucau acuagaacca      300

ucaugccuag gauaa                                                       315


<210>  4857
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL13__Homo_sapiens__Q99616

<400>  4857

Met Lys Val Ser Ala Val Leu Leu Cys Leu Leu Leu Met Thr Ala Ala 
1               5                   10                  15      


Phe Asn Pro Gln Gly Leu Ala Gln Pro Asp Ala Leu Asn Val Pro Ser 
            20                  25                  30          


Thr Cys Cys Phe Thr Phe Ser Ser Lys Lys Ile Ser Leu Gln Arg Leu 
        35                  40                  45              


Lys Ser Tyr Val Ile Thr Thr Ser Arg Cys Pro Gln Lys Ala Val Ile 
    50                  55                  60                  


Phe Arg Thr Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys 
65                  70                  75                  80  


Trp Val Gln Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Thr Leu 
                85                  90                  95      


Lys Thr 
        


<210>  4858
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL13__Homo_sapiens__AAB38703

<400>  4858
augaaagucu cugcagugcu ucugugccug cugcucauga cagcagcuuu caacccccag       60

ggacuugcuc agccagaugc acucaacguc ccaucuacuu gcugcuucac auuuagcagu      120

aagaagaucu ccuugcagag gcugaagagc uaugugauca ccaccagcag guguccccag      180

aaggcuguca ucuucagaac caaacugggc aaggagaucu gugcugaccc aaaggagaag      240

uggguccaga auuauaugaa acaccugggc cggaaagcuc acacccugaa gacuuga         297


<210>  4859
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL13__Homo_sapiens__AAB38703

<400>  4859
augaagguga gcgccguccu gcucugccug cugcucauga ccgccgcguu caacccccag       60

ggccuggccc agccggacgc ccugaacgug cccuccacgu gcugcuucac cuucagcucc      120

aagaagauca gccuccagcg ccugaagucc uacgugauca ccaccagccg gugcccccag      180

aaggccguca ucuuccgcac caagcugggg aaggagaucu gcgccgaccc caaggagaag      240

ugggugcaga acuacaugaa gcaccucggc cggaaggcgc acacgcugaa gaccuga         297


<210>  4860
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL13__Homo_sapiens__AAB38703

<400>  4860
augaaggucu ccgccguccu ccucugccuc cuccucauga ccgccgccuu caacccccag       60

ggccucgccc agcccgacgc ccucaacguc cccuccaccu gcugcuucac cuucuccucc      120

aagaagaucu cccuccagcg ccucaagucc uacgucauca ccaccucccg cugcccccag      180

aaggccguca ucuuccgcac caagcucggc aaggagaucu gcgccgaccc caaggagaag      240

uggguccaga acuacaugaa gcaccucggc cgcaaggccc acacccucaa gaccuga         297


<210>  4861
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL13__Homo_sapiens__AAB38703

<400>  4861
augaagguga gcgccguccu gcucugccuu cuguugauga ccgcugcauu caacccccag       60

ggcuuagccc aaccugacgc gcugaauguu ccauccacau guugcuuuac uuucucuagu      120

aaaaagaucu cacuacagag acucaaaagc uacgugauua cgaccuccag guguccgcag      180

aaggcuguaa uauuucggac aaaacugggg aaggagaucu gcgccgaucc caaggaaaaa      240

ugggugcaga acuauaugaa gcaccuugga cgcaaagcac auacucugaa gaccuga         297


<210>  4862
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL13__Homo_sapiens__AAB38703

<400>  4862
augaagguga gcgccgugcu gcugugccug cugcugauga ccgccgccuu caacccccag       60

ggccuggccc agcccgacgc ccugaacgug cccagcaccu gcugcuucac cuucagcagc      120

aagaagauca gccugcagag acugaagagc uacgugauca ccaccagcag augcccccag      180

aaggccguga ucuucagaac caagcugggc aaggagaucu gcgccgaccc caaggagaag      240

ugggugcaga acuacaugaa gcaccugggc agaaaggccc acacccugaa gaccuga         297


<210>  4863
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL13__Homo_sapiens__AAB38703

<400>  4863
augaagguga gcgccguccu gcucugccug cuucugauga ccgcugccuu caacccccag       60

ggccucgcgc aaccugacgc ucugaauguu ccguccacau guugcuuuac guucucuagc      120

aaaaagaucu cccuucagag acugaaaucu uacgugauua ccacaagccg guguccccag      180

aaggccguga ucuuucgcac caaacucggg aaggagauuu gcgccgaucc uaaggaaaaa      240

uggguccaga acuauaugaa gcaccuggga agaaaagcuc auacacugaa gaccuga         297


<210>  4864
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL13__Homo_sapiens__AAB38703

<400>  4864
augaaaguau cagcaguacu acuaugccua cuacuaauga cagcagcauu caacccacaa       60

ggacuagcac aaccagacgc acuaaacgua ccaucaacau gcugcuucac auucucauca      120

aaaaaaauau cacuacaaag acuaaaauca uacguaauaa caacaucaag augcccacaa      180

aaagcaguaa uauucagaac aaaacuagga aaagaaauau gcgcagaccc aaaagaaaaa      240

uggguacaaa acuacaugaa acaccuagga agaaaagcac acacacuaaa aacauaa         297


<210>  4865
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL14__Homo_sapiens__Q16627

<400>  4865

Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val Phe Ile Thr Lys Arg Gly His Ser Val Cys Thr Asn Pro Ser Asp 
65                  70                  75                  80  


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
                85                  90              


<210>  4866
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL14__Homo_sapiens__AAC63329

<400>  4866
augaagaucu ccguggcugc cauucccuuc uuccuccuca ucaccaucgc ccuagggacc       60

aagacugaau ccuccucacg gggaccuuac caccccucag agugcugcuu caccuacacu      120

accuacaaga ucccgcguca gcggauuaug gauuacuaug agaccaacag ccagugcucc      180

aagcccggaa uugucuucau caccaaaagg ggccauuccg ucuguaccaa ccccagugac      240

aagugggucc aggacuauau caaggacaug aaggagaacu ga                         282


<210>  4867
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL14__Homo_sapiens__AAC63329

<400>  4867
augaagauca gcguggccgc cauccccuuc uuccugcuca ucaccaucgc gcugggcacc       60

aagacggagu ccagcucccg cgggccguac caccccagcg agugcugcuu caccuacacc      120

accuacaaga ucccccggca gcgcaucaug gacuacuacg agacgaacuc ccagugcagc      180

aagcccggca ucgucuucau caccaagcgg gggcacuccg ugugcaccaa cccgagcgac      240

aagugggugc aggacuacau caaggacaug aaggagaacu ga                         282


<210>  4868
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL14__Homo_sapiens__AAC63329

<400>  4868
augaagaucu ccgucgccgc cauccccuuc uuccuccuca ucaccaucgc ccucggcacc       60

aagaccgagu ccuccucccg cggccccuac caccccuccg agugcugcuu caccuacacc      120

accuacaaga ucccccgcca gcgcaucaug gacuacuacg agaccaacuc ccagugcucc      180

aagcccggca ucgucuucau caccaagcgc ggccacuccg ucugcaccaa ccccuccgac      240

aagugggucc aggacuacau caaggacaug aaggagaacu ga                         282


<210>  4869
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL14__Homo_sapiens__AAC63329

<400>  4869
augaagauca gcguggccgc uauucccuuc uuucugcuca uaaccaucgc acuuggcaca       60

aaaacugagu ccucuucaag agggccuuac cacccaagug aaugcuguuu cacguauacc      120

acauacaaga uuccgaggca gcggaucaug gacuauuacg agacuaacag ccaaugcucc      180

aaacccggaa uugucuuuau caccaagcgc ggucauucug uuuguacaaa uccuucggau      240

aaaugggugc aggacuauau aaaggauaug aaggaaaacu ga                         282


<210>  4870
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL14__Homo_sapiens__AAC63329

<400>  4870
augaagauca gcguggccgc cauccccuuc uuccugcuga ucaccaucgc ccugggcacc       60

aagaccgaga gcagcagcag aggccccuac caccccagcg agugcugcuu caccuacacc      120

accuacaaga uccccagaca gagaaucaug gacuacuacg agaccaacag ccagugcagc      180

aagcccggca ucguguucau caccaagaga ggccacagcg ugugcaccaa ccccagcgac      240

aagugggugc aggacuacau caaggacaug aaggagaacu ga                         282


<210>  4871
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL14__Homo_sapiens__AAC63329

<400>  4871
augaagauca gcguggccgc uauucccuuc uuucugcuca ucaccauugc ccugggcaca       60

aaaacggagu ccucuagcag agggccuuac cacccguccg aaugcuguuu caccuauaca      120

accuacaaga ucccccggca gcgcauuaug gacuauuacg agacaaacuc ucaaugcagc      180

aaaccuggaa ucgucuuuau caccaagaga ggccauuccg uuuguacaaa ucccucugau      240

aaaugggugc aggacuauau uaaggauaug aaggaaaacu ga                         282


<210>  4872
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL14__Homo_sapiens__AAC63329

<400>  4872
augaaaauau caguagcagc aauaccauuc uuccuacuaa uaacaauagc acuaggaaca       60

aaaacagaau caucaucaag aggaccauac cacccaucag aaugcugcuu cacauacaca      120

acauacaaaa uaccaagaca aagaauaaug gacuacuacg aaacaaacuc acaaugcuca      180

aaaccaggaa uaguauucau aacaaaaaga ggacacucag uaugcacaaa cccaucagac      240

aaauggguac aagacuacau aaaagacaug aaagaaaacu aa                         282


<210>  4873
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL15__Homo_sapiens__Q16663

<400>  4873

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gln Phe Ile Asn Asp Ala Glu Thr Glu Leu Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Val Leu Asn Ser Phe His 
        35                  40                  45              


Phe Ala Ala Asp Cys Cys Thr Ser Tyr Ile Ser Gln Ser Ile Pro Cys 
    50                  55                  60                  


Ser Leu Met Lys Ser Tyr Phe Glu Thr Ser Ser Glu Cys Ser Lys Pro 
65                  70                  75                  80  


Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Gln Val Cys Ala Lys Pro 
                85                  90                  95      


Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser 
            100                 105                 110         


Ile 
    


<210>  4874
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL15__Homo_sapiens__AAB94617

<400>  4874
augaaggucu ccguggcugc ccucuccugc cucaugcuug uugcuguccu uggaucccag       60

gcccaguuca uaaaugaugc agagacagag uuaaugaugu caaagcuucc acuggaaaau      120

ccaguaguuc ugaacagcuu ucacuuugcu gcugacugcu gcaccuccua caucucacaa      180

agcaucccgu guucacucau gaaaaguuau uuugaaacga gcagcgagug cuccaagcca      240

ggugucauau uccucaccaa gaaggggagg caagucugug ccaaacccag ugguccggga      300

guucaggauu gcaugaaaaa gcugaagccc uacucaauau aa                         342


<210>  4875
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL15__Homo_sapiens__AAB94617

<400>  4875
augaagguga gcgucgccgc ccuguccugc cucaugcugg uggcggugcu gggcagccag       60

gcccaguuca ucaacgacgc cgagaccgag cucaugaugu ccaagcugcc ccuggagaac      120

ccggucgugc ucaacagcuu ccacuucgcc gccgacugcu gcaccuccua caucagccag      180

uccauccccu gcagccugau gaaguccuac uucgagacga gcuccgagug cagcaagccc      240

ggggugaucu uccugaccaa gaagggccgc caggucugcg cgaagcccuc cgggccgggc      300

gugcaggacu gcaugaagaa gcucaagccc uacagcaucu ga                         342


<210>  4876
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL15__Homo_sapiens__AAB94617

<400>  4876
augaaggucu ccgucgccgc ccucuccugc cucaugcucg ucgccguccu cggcucccag       60

gcccaguuca ucaacgacgc cgagaccgag cucaugaugu ccaagcuccc ccucgagaac      120

cccgucgucc ucaacuccuu ccacuucgcc gccgacugcu gcaccuccua caucucccag      180

uccauccccu gcucccucau gaaguccuac uucgagaccu ccuccgagug cuccaagccc      240

ggcgucaucu uccucaccaa gaagggccgc caggucugcg ccaagcccuc cggccccggc      300

guccaggacu gcaugaagaa gcucaagccc uacuccaucu ga                         342


<210>  4877
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL15__Homo_sapiens__AAB94617

<400>  4877
augaagguga gcgucgccgc ucuguccugc cucaugcuug uugcagugcu gggcucucag       60

gcccaauuca ucaacgacgc ggagaccgaa uugaugaugu caaaauuacc ccuggagaau      120

ccuguagugc uaaacaguuu ucacuucgcu gccgauuguu gcacaagcua cauuucccag      180

ucuauaccau guucgcucau gaagucauau uuugaaacua gcagugagug cuccaaaccg      240

ggggucaucu uccugacgaa gaaaggaaga caggugugug caaagcccuc ugguccuggc      300

guucaggacu gcaugaagaa acuuaagcca uacagcauuu ga                         342


<210>  4878
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL15__Homo_sapiens__AAB94617

<400>  4878
augaagguga gcguggccgc ccugagcugc cugaugcugg uggccgugcu gggcagccag       60

gcccaguuca ucaacgacgc cgagaccgag cugaugauga gcaagcugcc ccuggagaac      120

cccguggugc ugaacagcuu ccacuucgcc gccgacugcu gcaccagcua caucagccag      180

agcauccccu gcagccugau gaagagcuac uucgagacca gcagcgagug cagcaagccc      240

ggcgugaucu uccugaccaa gaagggcaga caggugugcg ccaagcccag cggccccggc      300

gugcaggacu gcaugaagaa gcugaagccc uacagcaucu ga                         342


<210>  4879
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL15__Homo_sapiens__AAB94617

<400>  4879
augaagguga gcgucgccgc ucuguccugc cucaugcugg uugccgugcu uggcucucag       60

gcgcaauuca ucaacgacgc ugagaccgaa cugaugauga gcaaacuccc ccuggagaau      120

ccuguggucc uuaacuccuu ucacuucgcc gccgauuguu gcacaucuua cauuagccag      180

uccaucccgu guucucugau gaaaagcuau uuugaaacgu ccagcgagug cucuaagccc      240

ggggugauuu uccucaccaa gaaaggaaga cagguuugug cuaagccuuc cggccccggg      300

gugcaggacu gcaugaagaa acugaagccu uacagcaucu ga                         342


<210>  4880
<211>  342
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL15__Homo_sapiens__AAB94617

<400>  4880
augaaaguau caguagcagc acuaucaugc cuaauguuag uagcaguacu aggaucacaa       60

gcacaauuca uaaacgacgc agaaacagaa cuaaugauga gcaaacuacc acuagaaaac      120

ccaguaguac uaaacucauu ccacuucgca gcagacugcu gcacaucaua cauaucacaa      180

ucaauaccau gcucacuaau gaaaucauac uucgaaacau caucagaaug cucaaaacca      240

ggaguaauau uccuaacaaa aaaaggaaga caaguaugcg caaaaccauc aggaccagga      300

guacaagacu gcaugaaaaa acuaaaacca uacucaauau aa                         342


<210>  4881
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL16__Homo_sapiens__O15467

<400>  4881

Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Thr Ser Ala Ser Arg Ser Gln Pro Lys Val Pro Glu Trp Val Asn 
            20                  25                  30          


Thr Pro Ser Thr Cys Cys Leu Lys Tyr Tyr Glu Lys Val Leu Pro Arg 
        35                  40                  45              


Arg Leu Val Val Gly Tyr Arg Lys Ala Leu Asn Cys His Leu Pro Ala 
    50                  55                  60                  


Ile Ile Phe Val Thr Lys Arg Asn Arg Glu Val Cys Thr Asn Pro Asn 
65                  70                  75                  80  


Asp Asp Trp Val Gln Glu Tyr Ile Lys Asp Pro Asn Leu Pro Leu Leu 
                85                  90                  95      


Pro Thr Arg Asn Leu Ser Thr Val Lys Ile Ile Thr Ala Lys Asn Gly 
            100                 105                 110         


Gln Pro Gln Leu Leu Asn Ser Gln 
        115                 120 


<210>  4882
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL16__Homo_sapiens__AAC05587

<400>  4882
augaaggucu ccgaggcugc ccugucucuc cuuguccuca uccuuaucau uacuucggcu       60

ucucgcagcc agccaaaagu uccugagugg gugaacaccc cauccaccug cugccugaag      120

uauuaugaga aaguguugcc aaggagacua guggugggau acagaaaggc ccucaacugu      180

caccugccag caaucaucuu cgucaccaag aggaaccgag aagucugcac caaccccaau      240

gacgacuggg uccaagagua caucaaggau cccaaccuac cuuugcugcc uaccaggaac      300

uuguccacgg uuaaaauuau uacagcaaag aauggucaac cccagcuccu caacucccag      360

uga                                                                    363


<210>  4883
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL16__Homo_sapiens__AAC05587

<400>  4883
augaagguga gcgaggccgc ccugucccuc cugguccuga uccucaucau caccagcgcg       60

ucccgcagcc agcccaaggu gccggagugg gugaacaccc ccuccacgug cugccugaag      120

uacuacgaga agguccugcc ccggcgccuc guggugggcu accggaaggc ccugaacugc      180

caccuccccg ccaucaucuu cgucaccaag cgcaaccggg aggugugcac caacccgaac      240

gacgacuggg ugcaggagua caucaaggac cccaaccugc cccugcugcc cacccgcaac      300

cucagcacgg ucaagaucau caccgccaag aacgggcagc cgcagcugcu gaacucccag      360

uga                                                                    363


<210>  4884
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL16__Homo_sapiens__AAC05587

<400>  4884
augaaggucu ccgaggccgc ccucucccuc cucguccuca uccucaucau caccuccgcc       60

ucccgcuccc agcccaaggu ccccgagugg gucaacaccc ccuccaccug cugccucaag      120

uacuacgaga agguccuccc ccgccgccuc gucgucggcu accgcaaggc ccucaacugc      180

caccuccccg ccaucaucuu cgucaccaag cgcaaccgcg aggucugcac caaccccaac      240

gacgacuggg uccaggagua caucaaggac cccaaccucc cccuccuccc cacccgcaac      300

cucuccaccg ucaagaucau caccgccaag aacggccagc cccagcuccu caacucccag      360

uga                                                                    363


<210>  4885
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL16__Homo_sapiens__AAC05587

<400>  4885
augaagguga gcgaggccgc ucugucccuc cuuguccuga ucuugauuau aaccucugca       60

ucaagaaguc agcccaaagu uccugaaugg gugaacacac caagcacuug cuguuuaaag      120

uacuaugaga aaguacugcc gaggcggcua guggucggcu accgcaaggc ccucaauugc      180

caccuucccg cgaucauuuu cgugacgaaa cgaaaccgug aaguuuguac caauccuaac      240

gacgauuggg ugcaagagua uaucaaggac ccaaaucugc cccuguugcc uacaagaaac      300

cucuccacug ucaagauuau caccgcuaaa aaugggcagc cacagcugcu gaacucucag      360

uga                                                                    363


<210>  4886
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL16__Homo_sapiens__AAC05587

<400>  4886
augaagguga gcgaggccgc ccugagccug cuggugcuga uccugaucau caccagcgcc       60

agcagaagcc agcccaaggu gcccgagugg gugaacaccc ccagcaccug cugccugaag      120

uacuacgaga aggugcugcc cagaagacug guggugggcu acagaaaggc ccugaacugc      180

caccugcccg ccaucaucuu cgugaccaag agaaacagag aggugugcac caaccccaac      240

gacgacuggg ugcaggagua caucaaggac cccaaccugc cccugcugcc caccagaaac      300

cugagcaccg ugaagaucau caccgccaag aacggccagc cccagcugcu gaacagccag      360

uga                                                                    363


<210>  4887
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL16__Homo_sapiens__AAC05587

<400>  4887
augaagguga gcgaggccgc ucugucccuc cugguccuua uccugauuau caccucugcc       60

agcagauccc agcccaaagu uccugaaugg gugaacacac cgucuacgug cugucucaag      120

uacuaugaga aagugcugcc ccggcgccuu gucgugggcu acagaaaggc gcugaauugc      180

caccucccug cuauuaucuu cguuaccaaa cggaaccgcg aaguguguac aaaucccaac      240

gacgauuggg uccaagagua uauuaaggac ccuaaucugc cccugcuccc uaccagaaac      300

cugagcacag ugaagaucau caccgccaaa aaugggcagc cgcagcuucu gaacucccag      360

uga                                                                    363


<210>  4888
<211>  363
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL16__Homo_sapiens__AAC05587

<400>  4888
augaaaguau cagaagcagc acuaucacua cuaguacuaa uacuaauaau aacaucagca       60

ucaagaucac aaccaaaagu cccagaaugg guaaacacac caucaacaug cugccuaaaa      120

uacuacgaaa aaguacuacc aagaagacua guaguaggau acagaaaagc acuaaacugc      180

caccuaccag caauaauauu cguaacaaaa agaaacagag aaguaugcac aaacccaaac      240

gacgacuggg uacaagaaua cauaaaagac ccaaaccuac cacuacuacc aacaagaaac      300

cuaucaacag ucaaaauaau aacagcaaaa aacggacaac cacaacuacu aaacucacaa      360

uaa                                                                    363


<210>  4889
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL17__Homo_sapiens__Q92583

<400>  4889

Met Ala Pro Leu Lys Met Leu Ala Leu Val Thr Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Thr Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Thr Trp Tyr Gln Thr Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Thr Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210>  4890
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL17__Homo_sapiens__AAH69107

<400>  4890
auggccccac ugaagaugcu ggcccugguc acccuccucc ugggggcuuc ucugcagcac       60

auccacgcag cucgagggac caaugugggc cgggagugcu gccuggagua cuucaaggga      120

gccauucccc uuagaaagcu gaagacgugg uaccagacau cugaggacug cuccagggau      180

gccaucguuu uuguaacugu gcagggcagg gccaucuguu cggaccccaa caacaagaga      240

gugaagaaug caguuaaaua ccugcaaagc cuugagaggu cuuga                      285


<210>  4891
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL17__Homo_sapiens__AAH69107

<400>  4891
auggcgcccc ugaagaugcu cgcccuggug acccugcucc ugggcgccag ccugcagcac       60

auccacgccg cccgcgggac caacgucggc cgggagugcu gccucgagua cuucaagggg      120

gccaucccgc ugcgcaagcu gaagacgugg uaccagaccu ccgaggacug cagccgggac      180

gccaucgugu ucgugaccgu ccagggccgc gcgaucugcu ccgaccccaa caacaagcgg      240

gugaagaacg ccgugaagua ccuccagagc cuggagcgcu ccuga                      285


<210>  4892
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL17__Homo_sapiens__AAH69107

<400>  4892
auggcccccc ucaagaugcu cgcccucguc acccuccucc ucggcgccuc ccuccagcac       60

auccacgccg cccgcggcac caacgucggc cgcgagugcu gccucgagua cuucaagggc      120

gccauccccc uccgcaagcu caagaccugg uaccagaccu ccgaggacug cucccgcgac      180

gccaucgucu ucgucaccgu ccagggccgc gccaucugcu ccgaccccaa caacaagcgc      240

gucaagaacg ccgucaagua ccuccagucc cucgagcgcu ccuga                      285


<210>  4893
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL17__Homo_sapiens__AAH69107

<400>  4893
auggcucccc ugaagaugcu cgcccuugug acccuguugu uaggcgcaag ccugcagcac       60

auccaugccg cgagagggac aaacgucgga agggagugcu gucuagaaua cuucaaaggu      120

gcuauuccuc uccggaagcu gaaaacuugg uaucaaacgu ccgaggacug cucucgcgau      180

gccauaguuu uugugaccgu acagggccga gcaaucuguu cagacccaaa uaacaagcgu      240

gugaaaaaug ccgucaagua ccuucagagu cuggaaagaa gcuga                      285


<210>  4894
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL17__Homo_sapiens__AAH69107

<400>  4894
auggcccccc ugaagaugcu ggcccuggug acccugcugc ugggcgccag ccugcagcac       60

auccacgccg ccagaggcac caacgugggc agagagugcu gccuggagua cuucaagggc      120

gccauccccc ugagaaagcu gaagaccugg uaccagacca gcgaggacug cagcagagac      180

gccaucgugu ucgugaccgu gcagggcaga gccaucugca gcgaccccaa caacaagaga      240

gugaagaacg ccgugaagua ccugcagagc cuggagagaa gcuga                      285


<210>  4895
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL17__Homo_sapiens__AAH69107

<400>  4895
auggcucccc ugaagaugcu cgcccuggug acccuucugc ucggcgccag ccugcagcac       60

auccaugcgg cuagagggac aaacgucgga cgggagugcu gucuugaaua cuucaaaggc      120

gccauuccuc ugcgcaagcu caaaacgugg uaucaaaccu ccgaggacug cucuagagau      180

gccaucguuu uugugacagu gcaggggcgg gcuauuugua gcgacccgaa uaacaagcgc      240

gucaaaaaug ccgugaagua ccugcagucc cuggaaagau cuuga                      285


<210>  4896
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL17__Homo_sapiens__AAH69107

<400>  4896
auggcaccac uaaaaaugcu agcacuagua acacuauuau uaggagcauc acuacaacac       60

auacacgcag caagaggaac aaacguagga agagaaugcu gccuagaaua cuucaaagga      120

gcaauaccac uaagaaaacu aaaaacaugg uaccaaacau cagaagacug cucaagagac      180

gcaauaguau ucguaacagu acaaggaaga gcaauaugcu cagacccaaa caacaaaaga      240

guaaaaaacg caguaaaaua ccuacaauca cuagaaagau cauaa                      285


<210>  4897
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL18__Homo_sapiens__P55774

<400>  4897

Met Lys Gly Leu Ala Ala Ala Leu Leu Val Leu Val Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Ser Cys Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu 
            20                  25                  30          


Val Tyr Thr Ser Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser 
        35                  40                  45              


Glu Thr Ser Pro Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys 
    50                  55                  60                  


Arg Gly Arg Gln Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys 
65                  70                  75                  80  


Tyr Ile Ser Asp Leu Lys Leu Asn Ala 
                85                  


<210>  4898
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL18__Homo_sapiens__AAC32287

<400>  4898
augaagggcc uugcagcugc ccuccuuguc cucgucugca ccauggcccu cugcuccugu       60

gcacaaguug guaccaacaa agagcucugc ugccucgucu auaccuccug gcagauucca      120

caaaaguuca uaguugacua uucugaaacc agcccccagu gccccaagcc aggugucauc      180

cuccuaacca agagaggccg gcagaucugu gcugacccca auaagaagug gguccagaaa      240

uacaucagcg accugaagcu gaaugccuga                                       270


<210>  4899
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL18__Homo_sapiens__AAC32287

<400>  4899
augaagggcc uggccgccgc gcuccuggug cuggucugca ccauggcccu cugcagcugc       60

gcccaggugg ggaccaacaa ggagcugugc ugccuggugu acacguccug gcagaucccc      120

cagaaguuca ucgucgacua cagcgagacc uccccgcagu gccccaagcc cggcgugauc      180

cuccugacca agcgcgggcg gcagaucugc gccgacccca acaagaagug ggugcagaag      240

uacaucagcg accugaagcu caacgccuga                                       270


<210>  4900
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL18__Homo_sapiens__AAC32287

<400>  4900
augaagggcc ucgccgccgc ccuccucguc cucgucugca ccauggcccu cugcuccugc       60

gcccaggucg gcaccaacaa ggagcucugc ugccucgucu acaccuccug gcagaucccc      120

cagaaguuca ucgucgacua cuccgagacc uccccccagu gccccaagcc cggcgucauc      180

cuccucacca agcgcggccg ccagaucugc gccgacccca acaagaagug gguccagaag      240

uacaucuccg accucaagcu caacgccuga                                       270


<210>  4901
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL18__Homo_sapiens__AAC32287

<400>  4901
augaagggcc uggccgcugc acuccuugug cuggucugca ccauggccuu guguagcugc       60

gcgcagguug ggacaaacaa agaguuaugu ugccuggugu acacuuccug gcaaaucccc      120

cagaaguuca uuguagacua uucugaaacg ucaccucagu guccaaaacc gggagugaua      180

cuacucacca agagagguag gcagaucugc gcugauccca auaaaaagug gguccaaaag      240

uacauuagug accugaaacu uaacgccuga                                       270


<210>  4902
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL18__Homo_sapiens__AAC32287

<400>  4902
augaagggcc uggccgccgc ccugcuggug cuggugugca ccauggcccu gugcagcugc       60

gcccaggugg gcaccaacaa ggagcugugc ugccuggugu acaccagcug gcagaucccc      120

cagaaguuca ucguggacua cagcgagacc agcccccagu gccccaagcc cggcgugauc      180

cugcugacca agagaggcag acagaucugc gccgacccca acaagaagug ggugcagaag      240

uacaucagcg accugaagcu gaacgccuga                                       270


<210>  4903
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL18__Homo_sapiens__AAC32287

<400>  4903
augaagggcc uggccgcugc ccuccuggug cuugucugca ccauggcgcu guguagcugc       60

gcucagguug ggacaaacaa agagcucugu ugccuggugu acacguccug gcaaaucccc      120

cagaaguuca uuguggacua uucugaaacc agcccucagu guccgaaacc cggagucauc      180

cuucugacaa agagaggccg gcagauuugc gccgauccua auaaaaagug ggugcaaaag      240

uacaucuccg accucaaacu gaacgccuga                                       270


<210>  4904
<211>  270
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL18__Homo_sapiens__AAC32287

<400>  4904
augaaaggac uagcagcagc acuacuagua cuaguaugca caauggcacu augcucaugc       60

gcacaaguag gaacaaacaa agaacuaugc ugccuaguau acacaucaug gcaaauacca      120

caaaaauuca uaguagacua cucagaaaca ucaccacaau gcccaaaacc aggaguaaua      180

cuacuaacaa aaagaggaag acaaauaugc gcagacccaa acaaaaaaug gguacaaaaa      240

uacauaucag accuaaaacu aaacgcauaa                                       270


<210>  4905
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL19__Homo_sapiens__Q6IBD6

<400>  4905

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  4906
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL19__Homo_sapiens__ABK41949

<400>  4906
auggcccugc uacuggcccu cagccugcug guucucugga cuuccccagc cccaacucug       60

aguggcacca augaugcuga agacugcugc cugucuguga cccagaaacc caucccuggg      120

uacaucguga ggaacuucca cuaccuucuc aucaaggaug gcugcagggu gccugcugua      180

guguucacca cacugagggg ccgccagcuc ugugcacccc cagaccagcc cuggguagaa      240

cgcaucaucc agagacugca gaggaccuca gccaagauga agcgccgcag caguuaa         297


<210>  4907
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL19__Homo_sapiens__ABK41949

<400>  4907
auggcccugc uccuggcccu gagccuccug gugcugugga ccucccccgc gccgacccuc       60

agcggcacga acgacgccga ggacugcugc cuguccguca cccagaagcc cauccccggg      120

uacaucgugc gcaacuucca cuaccugcuc aucaaggacg gcugccgggu gcccgccguc      180

guguucacca cccugcgcgg gcggcagcug ugcgccccgc ccgaccagcc cuggguggag      240

cgcaucaucc agcggcucca gcgcacgagc gccaagauga agcggcgcuc cagcuga         297


<210>  4908
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL19__Homo_sapiens__ABK41949

<400>  4908
auggcccucc uccucgcccu cucccuccuc guccucugga ccucccccgc ccccacccuc       60

uccggcacca acgacgccga ggacugcugc cucuccguca cccagaagcc cauccccggc      120

uacaucgucc gcaacuucca cuaccuccuc aucaaggacg gcugccgcgu ccccgccguc      180

gucuucacca cccuccgcgg ccgccagcuc ugcgcccccc ccgaccagcc cugggucgag      240

cgcaucaucc agcgccucca gcgcaccucc gccaagauga agcgccgcuc cuccuga         297


<210>  4909
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL19__Homo_sapiens__ABK41949

<400>  4909
auggcccugc uccuugcucu gagcuuguua gugcugugga cuucccccgc accuacacua       60

ucuggcacua acgacgccga ggauugcugu cucucaguca cgcagaagcc aaucccgggg      120

uacauuguua gaaauuucca cuaucugcuu auaaaagacg gaugcagggu gcccgcggua      180

guguuuacca cacugcgggg ucgccaauug ugugcuccuc cagaucagcc cugggucgaa      240

cgaaucauuc agcgucucca gagaaccagu gccaagauga aaaggcggag cuccuga         297


<210>  4910
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL19__Homo_sapiens__ABK41949

<400>  4910
auggcccugc ugcuggcccu gagccugcug gugcugugga ccagccccgc ccccacccug       60

agcggcacca acgacgccga ggacugcugc cugagcguga cccagaagcc cauccccggc      120

uacaucguga gaaacuucca cuaccugcug aucaaggacg gcugcagagu gcccgccgug      180

guguucacca cccugagagg cagacagcug ugcgcccccc ccgaccagcc cuggguggag      240

agaaucaucc agagacugca gagaaccagc gccaagauga agagaagaag cagcuga         297


<210>  4911
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL19__Homo_sapiens__ABK41949

<400>  4911
auggcccugc uccuggcccu uagccugcuc gugcugugga ccucccccgc cccuacacuu       60

ucuggcacga acgacgcgga ggauugcugu cugagcguca cccagaagcc gauccccggg      120

uacauuguua gaaauuucca cuaucuccug aucaaagacg gaugccgggu gccugcugug      180

gucuuuacaa cccugcgcgg cagacaacuc ugugcucccc cugaucagcc cuggguggaa      240

cggauuaucc agcgccugca gagaacaucc gccaagauga aacggcgcuc uagcuga         297


<210>  4912
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL19__Homo_sapiens__ABK41949

<400>  4912
auggcauuac uauuagcauu aagcuuacua guacuaugga caucaccagc accaacacua       60

ucaggaacaa acgaugcaga agacuguugc uuaagcguaa cacaaaaacc aauaccagga      120

uauauaguaa gaaauuucca uuacuuacua auaaaagaug gauguagagu accagcagua      180

guauucacaa cauuaagagg aagacaacua ugugcaccac cagaucaacc auggguagaa      240

agaauaauac aaagauuaca aagaacaagc gcaaaaauga aaagaagauc aagcuaa         297


<210>  4913
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL19__Homo_sapiens__Q99731

<400>  4913

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  4914
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL19__Homo_sapiens__AAC50944

<400>  4914
auggcccugc uacuggcccu cagccugcug guucucugga cuuccccagc cccaacucug       60

aguggcacca augaugcuga agacugcugc cugucuguga cccagaaacc caucccuggg      120

uacaucguga ggaacuucca cuaccuucuc aucaaggaug gcugcagggu gccugcugua      180

guguucacca cacugagggg ccgccagcuc ugugcacccc cagaccagcc cuggguagaa      240

cgcaucaucc agagacugca gaggaccuca gccaagauga agcgccgcag caguuaa         297


<210>  4915
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL19__Homo_sapiens__AAC50944

<400>  4915
auggcccugc uccuggcccu gagccuccug gugcugugga ccucccccgc gccgacccuc       60

agcggcacga acgacgccga ggacugcugc cuguccguca cccagaagcc cauccccggg      120

uacaucgugc gcaacuucca cuaccugcuc aucaaggacg gcugccgggu gcccgccguc      180

guguucacca cccugcgcgg gcggcagcug ugcgccccgc ccgaccagcc cuggguggag      240

cgcaucaucc agcggcucca gcgcacgagc gccaagauga agcggcgcuc cagcuga         297


<210>  4916
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL19__Homo_sapiens__AAC50944

<400>  4916
auggcccucc uccucgcccu cucccuccuc guccucugga ccucccccgc ccccacccuc       60

uccggcacca acgacgccga ggacugcugc cucuccguca cccagaagcc cauccccggc      120

uacaucgucc gcaacuucca cuaccuccuc aucaaggacg gcugccgcgu ccccgccguc      180

gucuucacca cccuccgcgg ccgccagcuc ugcgcccccc ccgaccagcc cugggucgag      240

cgcaucaucc agcgccucca gcgcaccucc gccaagauga agcgccgcuc cuccuga         297


<210>  4917
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL19__Homo_sapiens__AAC50944

<400>  4917
auggcccugc uccuugcucu gagcuuguua gugcugugga cuucccccgc accuacacua       60

ucuggcacua acgacgccga ggauugcugu cucucaguca cgcagaagcc aaucccgggg      120

uacauuguua gaaauuucca cuaucugcuu auaaaagacg gaugcagggu gcccgcggua      180

guguuuacca cacugcgggg ucgccaauug ugugcuccuc cagaucagcc cugggucgaa      240

cgaaucauuc agcgucucca gagaaccagu gccaagauga aaaggcggag cuccuga         297


<210>  4918
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL19__Homo_sapiens__AAC50944

<400>  4918
auggcccugc ugcuggcccu gagccugcug gugcugugga ccagccccgc ccccacccug       60

agcggcacca acgacgccga ggacugcugc cugagcguga cccagaagcc cauccccggc      120

uacaucguga gaaacuucca cuaccugcug aucaaggacg gcugcagagu gcccgccgug      180

guguucacca cccugagagg cagacagcug ugcgcccccc ccgaccagcc cuggguggag      240

agaaucaucc agagacugca gagaaccagc gccaagauga agagaagaag cagcuga         297


<210>  4919
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL19__Homo_sapiens__AAC50944

<400>  4919
auggcccugc uccuggcccu uagccugcuc gugcugugga ccucccccgc cccuacacuu       60

ucuggcacga acgacgcgga ggauugcugu cugagcguca cccagaagcc gauccccggg      120

uacauuguua gaaauuucca cuaucuccug aucaaagacg gaugccgggu gccugcugug      180

gucuuuacaa cccugcgcgg cagacaacuc ugugcucccc cugaucagcc cuggguggaa      240

cggauuaucc agcgccugca gagaacaucc gccaagauga aacggcgcuc uagcuga         297


<210>  4920
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL19__Homo_sapiens__AAC50944

<400>  4920
auggcauuac uauuagcauu aucauuacua guacuaugga caucaccagc accaacacua       60

ucaggaacaa acgaugcaga agacuguugc uuaagcguaa cacaaaaacc aauaccagga      120

uauauaguaa gaaauuucca uuacuuacua auaaaagaug gauguagagu accagcagua      180

guauucacaa cauuaagagg aagacaacua ugugcaccac cagaucaacc auggguagaa      240

agaauaauac aaagacuaca aagaacaagc gcaaaaauga aaagaagauc aagcuaa         297


<210>  4921
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL1__Homo_sapiens__P22362

<400>  4921

Met Gln Ile Ile Thr Thr Ala Leu Val Cys Leu Leu Leu Ala Gly Met 
1               5                   10                  15      


Trp Pro Glu Asp Val Asp Ser Lys Ser Met Gln Val Pro Phe Ser Arg 
            20                  25                  30          


Cys Cys Phe Ser Phe Ala Glu Gln Glu Ile Pro Leu Arg Ala Ile Leu 
        35                  40                  45              


Cys Tyr Arg Asn Thr Ser Ser Ile Cys Ser Asn Glu Gly Leu Ile Phe 
    50                  55                  60                  


Lys Leu Lys Arg Gly Lys Glu Ala Cys Ala Leu Asp Thr Val Gly Trp 
65                  70                  75                  80  


Val Gln Arg His Arg Lys Met Leu Arg His Cys Pro Ser Lys Arg Lys 
                85                  90                  95      






<210>  4922
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL1__Homo_sapiens__AAA52705

<400>  4922
augcagauca ucaccacagc ccuggugugc uugcugcuag cugggaugug gccggaagau       60

guggacagca agagcaugca gguacccuuc uccagauguu gcuucucauu ugcggagcaa      120

gagauucccc ugagggcaau ccuguguuac agaaauacca gcuccaucug cuccaaugag      180

ggcuuaauau ucaagcugaa gagaggcaaa gaggccugcg ccuuggacac aguuggaugg      240

guucagaggc acagaaaaau gcugaggcac ugcccgucaa aaagaaaaug a               291


<210>  4923
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL1__Homo_sapiens__AAA52705

<400>  4923
augcagauca ucaccaccgc ccuggugugc cuccugcugg ccggcaugug gcccgaggac       60

gucgacagca aguccaugca ggucccguuc agccgcugcu gcuucuccuu cgcggagcag      120

gagauccccc uccgggccau ccugugcuac cgcaacacga gcuccaucug cagcaacgag      180

gggcugaucu ucaagcucaa gcggggcaag gaggccugcg cccuggacac cguggggugg      240

gugcagcgcc accggaagau gcugcgccac ugccccucca agcggaagug a               291


<210>  4924
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL1__Homo_sapiens__AAA52705

<400>  4924
augcagauca ucaccaccgc ccucgucugc cuccuccucg ccggcaugug gcccgaggac       60

gucgacucca aguccaugca gguccccuuc ucccgcugcu gcuucuccuu cgccgagcag      120

gagauccccc uccgcgccau ccucugcuac cgcaacaccu ccuccaucug cuccaacgag      180

ggccucaucu ucaagcucaa gcgcggcaag gaggccugcg cccucgacac cgucggcugg      240

guccagcgcc accgcaagau gcuccgccac ugccccucca agcgcaagug a               291


<210>  4925
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL1__Homo_sapiens__AAA52705

<400>  4925
augcagauca uuaccacagc ccuggugugc cuccuucugg cuggcaugug gcccgaggac       60

gucgauagca aguccaugca aguuccuuuc ucuagauguu gcuuuucauu cgcagaacag      120

gagauaccau ugagggccau cuuauguuac cggaacacga guagcauuug cuccaaugaa      180

gggcugaucu uuaaacuaaa gcgcggaaaa gaggcgugug cucucgacac uguggguugg      240

guacagcgac accguaagau gcugagacau ugcccgucua aaaggaagug a               291


<210>  4926
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL1__Homo_sapiens__AAA52705

<400>  4926
augcagauca ucaccaccgc ccuggugugc cugcugcugg ccggcaugug gcccgaggac       60

guggacagca agagcaugca ggugcccuuc agcagaugcu gcuucagcuu cgccgagcag      120

gagauccccc ugagagccau ccugugcuac agaaacacca gcagcaucug cagcaacgag      180

ggccugaucu ucaagcugaa gagaggcaag gaggccugcg cccuggacac cgugggcugg      240

gugcagagac acagaaagau gcugagacac ugccccagca agagaaagug a               291


<210>  4927
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL1__Homo_sapiens__AAA52705

<400>  4927
augcagauca uuaccacagc ccuggugugc cuccugcuug cuggcaugug gcccgaggac       60

gucgauagca aguccaugca aguuccuuuc ucuagauguu gcuuuagcuu cgccgaacag      120

gagaucccgc ugcgggcgau ucucuguuac cgcaacacgu ccucuaucug cagcaaugaa      180

gggcugauuu uuaaacuuaa gagaggaaaa gaggcuugug cccuggacac cgugggcugg      240

gugcagcggc accgcaagau gcucagacau ugccccucca aacggaagug a               291


<210>  4928
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL1__Homo_sapiens__AAA52705

<400>  4928
augcaaauaa uaacaacagc auuaguaugu cuauuacuag caggaaugug gccagaagau       60

guagauagca aaagcaugca aguaccauuu agcagaugcu guuucucauu cgcagaacaa      120

gaaauaccau uaagagcaau auuaugcuau agaaauacau caagcauaug cucaaacgaa      180

ggauuaauau uuaaauuaaa aagaggaaaa gaagcaugcg cacuagauac aguaggaugg      240

guacaaagac auagaaaaau guuaagacau ugcccaagca aaagaaaaua a               291


<210>  4929
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL20__Homo_sapiens__P78556

<400>  4929

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      






<210>  4930
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL20__Homo_sapiens__AAC50943

<400>  4930
augugcugua ccaagaguuu gcuccuggcu gcuuugaugu cagugcugcu acuccaccuc       60

ugcggcgaau cagaagcagc aagcaacuuu gacugcuguc uuggauacac agaccguauu      120

cuucauccua aauuuauugu gggcuucaca cggcagcugg ccaaugaagg cugugacauc      180

aaugcuauca ucuuucacac aaagaaaaag uugucugugu gcgcaaaucc aaaacagacu      240

ugggugaaau auauugugcg ucuccucagu aaaaaaguca agaacaugua a               291


<210>  4931
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL20__Homo_sapiens__AAC50943

<400>  4931
augugcugca ccaagagccu gcuccuggcc gcccugaugu ccgugcuccu gcugcaccuc       60

ugcggcgaga gcgaggcggc cuccaacuuc gacugcugcc ugggguacac cgaccgcauc      120

cugcacccca aguucaucgu cggcuucacg cggcagcucg ccaacgaggg gugcgacauc      180

aacgccauca ucuuccacac caagaagaag cugagcgugu gcgccaaccc gaagcagacc      240

ugggugaagu acaucguccg ccugcucucc aagaagguga agaacaugug a               291


<210>  4932
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL20__Homo_sapiens__AAC50943

<400>  4932
augugcugca ccaagucccu ccuccucgcc gcccucaugu ccguccuccu ccuccaccuc       60

ugcggcgagu ccgaggccgc cuccaacuuc gacugcugcc ucggcuacac cgaccgcauc      120

cuccacccca aguucaucgu cggcuucacc cgccagcucg ccaacgaggg cugcgacauc      180

aacgccauca ucuuccacac caagaagaag cucuccgucu gcgccaaccc caagcagacc      240

ugggucaagu acaucguccg ccuccucucc aagaagguca agaacaugug a               291


<210>  4933
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL20__Homo_sapiens__AAC50943

<400>  4933
augugcugua ccaagagccu gcuccuugcc gcucugaugu ccguguuguu acugcaccua       60

ugcggcgagu cugaagcagc cucaaacuuc gacuguugcc ucggguacac agauagaauc      120

cugcauccca aauuuauugu cggauucacu aggcagcuug cgaaugaggg uugugacaua      180

aacgcuauca uuuuucacac gaagaaaaag cugaguguuu gcgccaaucc uaaacaaacc      240

ugggugaagu auaucguacg guugcucagc aagaaaguga agaacaugug a               291


<210>  4934
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL20__Homo_sapiens__AAC50943

<400>  4934
augugcugca ccaagagccu gcugcuggcc gcccugauga gcgugcugcu gcugcaccug       60

ugcggcgaga gcgaggccgc cagcaacuuc gacugcugcc ugggcuacac cgacagaauc      120

cugcacccca aguucaucgu gggcuucacc agacagcugg ccaacgaggg cugcgacauc      180

aacgccauca ucuuccacac caagaagaag cugagcgugu gcgccaaccc caagcagacc      240

ugggugaagu acaucgugag acugcugagc aagaagguga agaacaugug a               291


<210>  4935
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL20__Homo_sapiens__AAC50943

<400>  4935
augugcugua ccaagagccu gcuccuggcc gcucuuaugu ccgugcugcu ccugcaccuu       60

ugcggcgagu cugaagccgc gagcaacuuc gacuguugcc ugggguacac agauagaauc      120

cuccauccca aauuuauugu cggauucacg cggcagcugg cuaaugaggg cugugacauc      180

aacgccauua ucuuucacac caagaaaaag cuguccguuu gcgccaaucc uaaacaaaca      240

ugggugaagu auauugugcg ccuccugucu aagaaaguca agaacaugug a               291


<210>  4936
<211>  291
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL20__Homo_sapiens__AAC50943

<400>  4936
augugcugca caaaaucacu acuacuagca gcacuaaugu caguacuauu acuacaccua       60

ugcggagaau cagaagcagc aucaaacuuc gacugcugcc uaggauacac agacagaaua      120

cuacacccaa aauucauagu aggauucaca agacaacuag caaacgaagg augcgacaua      180

aacgcaauaa uauuccacac aaaaaaaaaa cuaucaguau gcgcaaaccc aaaacaaaca      240

uggguaaaau acauaguaag acuacuauca aaaaaaguaa aaaacaugua a               291


<210>  4937
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL21__Homo_sapiens__O00585

<400>  4937

Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser 
        115                 120                 125             


Gln Thr Pro Lys Gly Pro 
    130                 


<210>  4938
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL21__Homo_sapiens__AAB86594

<400>  4938
auggcucagu cacuggcucu gagccuccuu auccugguuc uggccuuugg aauccccagg       60

acccaaggca gugauggagg ggcucaggac uguugccuca aguacagcca aaggaagauu      120

cccgccaagg uuguccgcag cuaccggaag caggaaccaa gcuuaggcug cuccauccca      180

gcuauccugu ucuugccccg caagcgcucu caggcagagc uaugugcaga cccaaaggag      240

cucugggugc agcagcugau gcagcaucug gacaagacac cauccccaca gaaaccagcc      300

cagggcugca ggaaggacag gggggccucc aagacuggca agaaaggaaa gggcuccaaa      360

ggcugcaaga ggacugagcg gucacagacc ccuaaagggc cauag                      405


<210>  4939
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL21__Homo_sapiens__AAB86594

<400>  4939
auggcccaga gccuggcccu cucccugcug auccucgugc uggcguucgg caucccccgc       60

acccagggga gcgacggcgg ggcccaggac ugcugccuga aguacuccca gcggaagauc      120

ccggccaagg ucgugcgcag cuaccggaag caggagcccu cccucggcug cagcaucccc      180

gccauccugu uccugccccg caagcggucc caggccgagc ucugcgcgga cccgaaggag      240

cugugggugc agcagcugau gcagcaccuc gacaagaccc ccagccccca gaagcccgcc      300

caggggugcc gcaaggaccg gggcgccucc aagacgggca agaaggggaa gggcagcaag      360

gggugcaagc gcaccgagcg gucccagacc ccgaagggcc ccuga                      405


<210>  4940
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL21__Homo_sapiens__AAB86594

<400>  4940
auggcccagu cccucgcccu cucccuccuc auccucgucc ucgccuucgg caucccccgc       60

acccagggcu ccgacggcgg cgcccaggac ugcugccuca aguacuccca gcgcaagauc      120

cccgccaagg ucguccgcuc cuaccgcaag caggagcccu cccucggcug cuccaucccc      180

gccauccucu uccucccccg caagcgcucc caggccgagc ucugcgccga ccccaaggag      240

cucugggucc agcagcucau gcagcaccuc gacaagaccc ccucccccca gaagcccgcc      300

cagggcugcc gcaaggaccg cggcgccucc aagaccggca agaagggcaa gggcuccaag      360

ggcugcaagc gcaccgagcg cucccagacc cccaagggcc ccuga                      405


<210>  4941
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL21__Homo_sapiens__AAB86594

<400>  4941
auggcccaga gccuggcucu cucccuucug aucuuggugu uagcauucgg cauucccaga       60

acccaagggu cugacggagg ugcccaggau ugcugucuga aguacucaca gaggaaaaua      120

ccugcgaagg ucguucggag uuaucgcaaa caggagccaa gccuaggcug cuccaucccg      180

gcuauucucu uucugccccg aaagcguucu caagccgaac uuugugcaga cccuaaagag      240

cugugggugc agcaguugau gcagcaccuc gauaagacac caucgcccca aaagccugcc      300

caggggugca gaaaagacag gggagcuuca aagacuggca aaaaggguaa agggagcaag      360

ggauguaagc ggacggaacg cagucagacc ccaaaaggcc ccuga                      405


<210>  4942
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL21__Homo_sapiens__AAB86594

<400>  4942
auggcccaga gccuggcccu gagccugcug auccuggugc uggccuucgg cauccccaga       60

acccagggca gcgacggcgg cgcccaggac ugcugccuga aguacagcca gagaaagauc      120

cccgccaagg uggugagaag cuacagaaag caggagccca gccugggcug cagcaucccc      180

gccauccugu uccugcccag aaagagaagc caggccgagc ugugcgccga ccccaaggag      240

cugugggugc agcagcugau gcagcaccug gacaagaccc ccagccccca gaagcccgcc      300

cagggcugca gaaaggacag aggcgccagc aagaccggca agaagggcaa gggcagcaag      360

ggcugcaaga gaaccgagag aagccagacc cccaagggcc ccuga                      405


<210>  4943
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL21__Homo_sapiens__AAB86594

<400>  4943
auggcccaga gccuggcucu cucccugcuu auccuggugc ucgccuucgg cauucccaga       60

acccaagggu cugacggagg cgcgcaggau ugcugucuga aguacagcca gcggaaaauc      120

ccugcuaagg ucguucgcuc cuauagaaaa caggagccgu cucuugggug cagcauuccc      180

gccauccugu uucucccucg gaagcgcucc caagccgaac ugugugcuga ccccaaagag      240

cugugggugc agcagcucau gcagcaccug gauaagacac cuucucccca aaagccugcc      300

cagggaugca gaaaagaccg gggcgcuagc aagacgggga aaaagggaaa aggcuccaag      360

ggcuguaagc gcaccgaaag aagccagaca ccgaaagggc ccuga                      405


<210>  4944
<211>  405
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL21__Homo_sapiens__AAB86594

<400>  4944
auggcacaau cauuagcacu aucacuacua auacuaguau uagcauucgg aauaccaaga       60

acacaaggau cagacggagg agcacaagac ugcugccuaa aauacucaca aagaaaaaua      120

ccagcaaaag uaguaagauc auacagaaaa caagaaccau cacuaggaug cucaauacca      180

gcaauacuau uccuaccaag aaaaagauca caagcagaac uaugcgcaga cccaaaagaa      240

cuauggguac aacaacucau gcaacacuua gacaaaacac caagcccaca aaaaccagca      300

caaggaugca gaaaagacag aggagcauca aaaacaggaa aaaaaggaaa aggaucaaaa      360

ggaugcaaaa gaacagaacg aucacaaaca ccaaaaggac cauaa                      405


<210>  4945
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL22__Homo_sapiens__O00626

<400>  4945

Met Asp Arg Leu Gln Thr Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Thr Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Thr Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Thr Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210>  4946
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL22__Homo_sapiens__BAG34909

<400>  4946
auggaucgcc uacagacugc acuccugguu guccucgucc uccuugcugu ggcgcuucaa       60

gcaacugagg caggccccua cggcgccaac auggaagaca gcgucugcug ccgugauuac      120

guccguuacc gucugccccu gcgcguggug aaacacuucu acuggaccuc agacuccugc      180

ccgaggccug gcgugguguu gcuaaccuuc agggauaagg agaucugugc cgaucccaga      240

gugcccuggg ugaagaugau ucucaauaag cugagccaau ga                         282


<210>  4947
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL22__Homo_sapiens__BAG34909

<400>  4947
auggaccgcc ugcagaccgc ccuccuggug guccuggugc uccuggccgu ggcgcugcag       60

gccaccgagg ccggccccua cggggccaac auggaggaca gcgucugcug ccgggacuac      120

gugcgcuacc ggcucccgcu gcgcgugguc aagcacuucu acuggacguc cgacagcugc      180

ccccggcccg gcguggugcu gcucaccuuc cgcgacaagg agaucugcgc cgacccccgg      240

gucccguggg ugaagaugau ccugaacaag cugucccagu ga                         282


<210>  4948
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL22__Homo_sapiens__BAG34909

<400>  4948
auggaccgcc uccagaccgc ccuccucguc guccucgucc uccucgccgu cgcccuccag       60

gccaccgagg ccggccccua cggcgccaac auggaggacu ccgucugcug ccgcgacuac      120

guccgcuacc gccucccccu ccgcgucguc aagcacuucu acuggaccuc cgacuccugc      180

ccccgccccg gcgucguccu ccucaccuuc cgcgacaagg agaucugcgc cgacccccgc      240

guccccuggg ucaagaugau ccucaacaag cucucccagu ga                         282


<210>  4949
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL22__Homo_sapiens__BAG34909

<400>  4949
auggacagac ugcagaccgc ccuccuugug guccugguuu uguuagcugu ggcacugcaa       60

gccacagagg cgggccccua cggggcuaac auggaagaua gcguaugcug uagggacuau      120

gugcgguacc gccuaccucu ccgagucgug aagcacuucu auuggacuuc cgauucuugc      180

ccacguccgg gaguugugcu gcuuacguuu agagacaaag agaucugugc cgaucccagg      240

gucccuuggg ugaagaugau ucugaauaaa uugucacagu ga                         282


<210>  4950
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL22__Homo_sapiens__BAG34909

<400>  4950
auggacagac ugcagaccgc ccugcuggug gugcuggugc ugcuggccgu ggcccugcag       60

gccaccgagg ccggccccua cggcgccaac auggaggaca gcgugugcug cagagacuac      120

gugagauaca gacugccccu gagaguggug aagcacuucu acuggaccag cgacagcugc      180

cccagacccg gcguggugcu gcugaccuuc agagacaagg agaucugcgc cgaccccaga      240

gugcccuggg ugaagaugau ccugaacaag cugagccagu ga                         282


<210>  4951
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL22__Homo_sapiens__BAG34909

<400>  4951
auggacagac ugcagaccgc ccuccuggug guccuuguuc ugcucgcugu ggcccugcaa       60

gcgacagagg cuggccccua cggggccaac auggaagaua gcgugugcug ucgggacuau      120

guccgcuaca gacuuccucu gcgggugguu aagcacuucu auuggacguc cgauucuugc      180

ccgcgccccg gagugguccu ccugaccuuu agagacaaag agaucugugc cgauccucgg      240

gugcccuggg uuaagaugau ucugaauaaa cucagccagu ga                         282


<210>  4952
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL22__Homo_sapiens__BAG34909

<400>  4952
auggacagac uacaaacagc acuauuagua guacuaguac uauuagcagu agcauuacaa       60

gcaacagaag caggaccaua uggagcaaac auggaagaua gcguaugcug uagagauuac      120

guaagauaua gauuaccauu aagaguagua aaacacuuuu acuggacauc agacucaugc      180

ccaagaccag gaguaguauu acuaacauuc agagacaaag aaauaugcgc agacccaaga      240

guaccauggg uaaaaaugau acuaaauaaa uuaagccaau aa                         282


<210>  4953
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL24__Homo_sapiens__O00175

<400>  4953

Met Ala Gly Leu Met Thr Ile Val Thr Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Thr Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Thr Thr Cys 
        115                 


<210>  4954
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL24__Homo_sapiens__AAD15410

<400>  4954
auggcaggcc ugaugaccau aguaaccagc cuucuguucc uuggugucug ugcccaccac       60

aucaucccua cgggcucugu ggucaucccc ucucccugcu gcauguucuu uguuuccaag      120

agaauuccug agaaccgagu ggucagcuac cagcugucca gcaggagcac augccucaag      180

gcaggaguga ucuucaccac caagaagggc cagcaguucu guggcgaccc caagcaggag      240

uggguccaga gguacaugaa gaaccuggac gccaagcaga agaaggcuuc cccuagggcc      300

agggcagugg cugucaaggg cccuguccag agauauccug gcaaccaaac caccugcuaa      360


<210>  4955
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL24__Homo_sapiens__AAD15410

<400>  4955
auggccggcc ugaugaccau cgugaccagc cuccuguucc ugggggucug cgcccaccac       60

aucaucccca cgggcuccgu ggugaucccg agccccugcu gcauguucuu cgucuccaag      120

cgcauccccg agaaccgggu ggugagcuac cagcucucca gccgcuccac cugccugaag      180

gcggggguca ucuucaccac caagaagggc cagcaguucu gcggggaccc caagcaggag      240

ugggugcagc gguacaugaa gaaccuggac gccaagcaga agaaggccag cccgcgcgcc      300

cgggccgugg cggucaaggg ccccgugcag cgcuaccccg gcaaccagac gaccugcuga      360


<210>  4956
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL24__Homo_sapiens__AAD15410

<400>  4956
auggccggcc ucaugaccau cgucaccucc cuccucuucc ucggcgucug cgcccaccac       60

aucaucccca ccggcuccgu cgucaucccc ucccccugcu gcauguucuu cgucuccaag      120

cgcauccccg agaaccgcgu cgucuccuac cagcucuccu cccgcuccac cugccucaag      180

gccggcguca ucuucaccac caagaagggc cagcaguucu gcggcgaccc caagcaggag      240

uggguccagc gcuacaugaa gaaccucgac gccaagcaga agaaggccuc cccccgcgcc      300

cgcgccgucg ccgucaaggg ccccguccag cgcuaccccg gcaaccagac caccugcuga      360


<210>  4957
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL24__Homo_sapiens__AAD15410

<400>  4957
auggccggcc ugaugaccau cgugacaagc cuccuuuucc ugggggucug cgcucaccau       60

auuauaccca cuggauccgu ugugaucccu ucuccauguu gcauguuuuu cguaucaaag      120

aggauuccgg agaacagagu ggucaguuac caguugagcu cccggucuac guguuuaaaa      180

gccgguguga ucuuuaccac aaagaaaggc caacaguucu gcggggaccc caagcaggaa      240

uggguucagc gcuauaugaa aaaucuggau gcaaagcaaa agaaagcguc gccucgagcu      300

cgugccgugg cagucaaggg accagugcag agauaccccg gcaaccagac uaccuguuga      360


<210>  4958
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL24__Homo_sapiens__AAD15410

<400>  4958
auggccggcc ugaugaccau cgugaccagc cugcuguucc ugggcgugug cgcccaccac       60

aucaucccca ccggcagcgu ggugaucccc agccccugcu gcauguucuu cgugagcaag      120

agaauccccg agaacagagu ggugagcuac cagcugagca gcagaagcac cugccugaag      180

gccggcguga ucuucaccac caagaagggc cagcaguucu gcggcgaccc caagcaggag      240

ugggugcaga gauacaugaa gaaccuggac gccaagcaga agaaggccag ccccagagcc      300

agagccgugg ccgugaaggg ccccgugcag agauaccccg gcaaccagac caccugcuga      360


<210>  4959
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL24__Homo_sapiens__AAD15410

<400>  4959
auggccggcc ugaugaccau cgugacaagc cuccuguucc uuggggucug cgcucaccau       60

auuaucccca cgggauccgu ugugauuccu ucuccguguu gcauguuuuu cgugagcaag      120

agaauccccg agaaccgggu cguguccuac cagcugucua gccgcuccac cugucucaaa      180

gccggcguua uuuuuacaac caagaaaggg caacaguucu gcggagaccc uaagcaggaa      240

ugggugcaga gauauaugaa aaaucuggau gcgaagcaaa agaaggcuuc uccccgggcc      300

cgcgccgucg cugugaaagg cccuguucag agauaccccg ggaaccagac aaccuguuga      360


<210>  4960
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL24__Homo_sapiens__AAD15410

<400>  4960
auggcaggau uaaugacaau aguaacauca cuauuauucu uaggaguaug cgcacaccau       60

auaauaccaa caggaucagu aguaauacca agcccaugcu guauguuuuu cguaagcaaa      120

agaauaccag aaaacagagu aguaagcuau caauuaagcu caagaucaac augucuaaaa      180

gcaggaguaa uauucacaac aaaaaaagga caacaauucu guggagaccc aaaacaagaa      240

uggguacaaa gauacaugaa aaaucuagac gcaaaacaaa aaaaagcaag cccaagagca      300

agagcaguag caguaaaagg accaguacaa agauauccag gaaaccaaac aacaugcuaa      360


<210>  4961
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL25__Homo_sapiens__O15444

<400>  4961

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Thr Gln Thr Phe Gln Ala Gly Pro His 
            100                 105                 110         


Ala Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys 
        115                 120                 125             


Phe Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile 
    130                 135                 140                 


Ser Ala Asn Ser Gly Leu 
145                 150 


<210>  4962
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL25__Homo_sapiens__AAI30562

<400>  4962
augaaccugu ggcuccuggc cugccuggug gccggcuucc ugggagccug ggcccccgcu       60

guccacaccc aaggugucuu ugaggacugc ugccuggccu accacuaccc cauugggugg      120

gcugugcucc ggcgcgccug gacuuaccgg auccaggagg ugagcgggag cugcaaucug      180

ccugcugcga uauucuaccu ccccaagaga cacaggaagg ugugugggaa ccccaaaagc      240

agggaggugc agagagccau gaagcuccug gaugcucgaa auaagguuuu ugcaaagcuc      300

caccacaaca cgcagaccuu ccaagcaggc ccucaugcug uaaagaaguu gaguucugga      360

aacuccaagu uaucaucauc caaguuuagc aaucccauca gcagcagcaa gaggaauguc      420

ucccuccuga uaucagcuaa uucaggacug uga                                   453


<210>  4963
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL25__Homo_sapiens__AAI30562

<400>  4963
augaaccugu ggcuccuggc cugccuggug gccggcuucc ucggggcgug ggcccccgcc       60

guccacaccc agggcguguu cgaggacugc ugccuggccu accacuaccc gaucgggugg      120

gccgugcugc gccgggcgug gaccuaccgc auccaggagg ucagcggcuc cugcaaccuc      180

cccgccgcca ucuucuaccu gcccaagcgg caccgcaagg ugugcgggaa ccccaagagc      240

cgggaggugc agcgcgccau gaagcugcuc gacgcgcgga acaaggucuu cgccaagcug      300

caccacaaca cgcagaccuu ccaggccggc ccgcacgccg ugaagaagcu guccagcggc      360

aacuccaagc ucagcuccag caaguucucc aaccccauca gcuccagcaa gcgcaacgug      420

ucccugcuga ucagcgccaa cuccgggcuc uga                                   453


<210>  4964
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL25__Homo_sapiens__AAI30562

<400>  4964
augaaccucu ggcuccucgc cugccucguc gccggcuucc ucggcgccug ggcccccgcc       60

guccacaccc agggcgucuu cgaggacugc ugccucgccu accacuaccc caucggcugg      120

gccguccucc gccgcgccug gaccuaccgc auccaggagg ucuccggcuc cugcaaccuc      180

cccgccgcca ucuucuaccu ccccaagcgc caccgcaagg ucugcggcaa ccccaagucc      240

cgcgaggucc agcgcgccau gaagcuccuc gacgcccgca acaaggucuu cgccaagcuc      300

caccacaaca cccagaccuu ccaggccggc ccccacgccg ucaagaagcu cuccuccggc      360

aacuccaagc ucuccuccuc caaguucucc aaccccaucu ccuccuccaa gcgcaacguc      420

ucccuccuca ucuccgccaa cuccggccuc uga                                   453


<210>  4965
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL25__Homo_sapiens__AAI30562

<400>  4965
augaaccugu ggcuccuugc cugccuggug gcuggcuucu ugggggcaug ggcccccgcg       60

guccacaccc agggaguuuu ugaggacugu ugcuuagcuu accauuaucc uaucgguugg      120

gccgugcuga gaagggcaug gacauaccgg auucaagaag uaagcggcuc cuguaaucua      180

ccagccgcua uauucuaucu cccgaagcgc caccgaaaag ugugcgggaa ccccaagucu      240

cgugaggucc agagagcaau gaaacugcuu gaugccagga auaagguguu ugcuaaacug      300

caucacaaca cucagacguu ccaggccgga ccucaugcgg uuaagaaguu gucaaguggc      360

aauagcaaac ucuccucuuc gaaguuuuca aacccaauca gcaguuccaa acggaaugug      420

ucucugcuga uuagcgcaaa cuccggucuc uga                                   453


<210>  4966
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL25__Homo_sapiens__AAI30562

<400>  4966
augaaccugu ggcugcuggc cugccuggug gccggcuucc ugggcgccug ggcccccgcc       60

gugcacaccc agggcguguu cgaggacugc ugccuggccu accacuaccc caucggcugg      120

gccgugcuga gaagagccug gaccuacaga auccaggagg ugagcggcag cugcaaccug      180

cccgccgcca ucuucuaccu gcccaagaga cacagaaagg ugugcggcaa ccccaagagc      240

agagaggugc agagagccau gaagcugcug gacgccagaa acaagguguu cgccaagcug      300

caccacaaca cccagaccuu ccaggccggc ccccacgccg ugaagaagcu gagcagcggc      360

aacagcaagc ugagcagcag caaguucagc aaccccauca gcagcagcaa gagaaacgug      420

agccugcuga ucagcgccaa cagcggccug uga                                   453


<210>  4967
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL25__Homo_sapiens__AAI30562

<400>  4967
augaaccugu ggcuccuggc cugccuugug gcuggcuucc ugggggccug ggcgcccgcu       60

guccacaccc agggaguuuu ugaggacugu ugccucgccu accauuaucc uaucggcugg      120

gccgugcuga gacgggcuug gacauaccgc auucaagaag ugagcggguc cuguaaucuu      180

ccggccgcua ucuucuaucu gcccaagaga caccggaaag ucugcggaaa cccuaagucu      240

cgcgaggugc agagagccau gaaacuccug gaugcgcgga auaagguuuu ugccaaacug      300

caucacaaca cgcagaccuu ccaggcuggc ccccaugccg ugaagaagcu cagcuccgga      360

aauucuaaac ugagcuccuc uaaguuuagc aacccuauuu ccagcucuaa acgcaauguc      420

ucccuucuga ucagcgcuaa cucugggcuc uga                                   453


<210>  4968
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL25__Homo_sapiens__AAI30562

<400>  4968
augaaucuau ggcuacuagc cugccuagua gcaggauucc uaggagcaug ggcaccagca       60

guacacacac aaggaguauu cgaagacugc ugccuagcau accacuaccc aauaggaugg      120

gcaguacuaa gaagagcaug gacauacaga auacaagaag uaucaggauc augcaacuua      180

ccagcagcaa uauucuaccu accaaaaaga cacagaaaag uaugcggaaa cccaaaauca      240

agagaaguac aaagagcaau gaaacuacua gacgcaagaa acaaaguauu cgcaaaacua      300

caccacaaca cacaaacauu ccaagcagga ccacacgcag uaaaaaaauu aucaucaggc      360

aacuccaaac uaucaucauc aaaauucuca aacccaauau caucaucaaa aagaaacgua      420

ucacuacuaa uaucagcaaa cucaggacua uaa                                   453


<210>  4969
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL26__Homo_sapiens__Q9Y258

<400>  4969

Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210>  4970
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL26__Homo_sapiens__AAD15411

<400>  4970
augaugggcc ucuccuuggc cucugcugug cuccuggccu cccuccugag ucuccaccuu       60

ggaacugcca cacgugggag ugacauaucc aagaccugcu gcuuccaaua cagccacaag      120

ccccuucccu ggaccugggu gcgaagcuau gaauucacca guaacagcug cucccagcgg      180

gcugugauau ucacuaccaa aagaggcaag aaagucugua cccauccaag gaaaaaaugg      240

gugcaaaaau acauuucuuu acugaaaacu ccgaaacaau uguga                      285


<210>  4971
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL26__Homo_sapiens__AAD15411

<400>  4971
augaugggcc ugagccucgc cuccgccgug cugcuggcga gccuccuguc ccugcaccuc       60

gggaccgcca cccgcggcag cgacaucucc aagacgugcu gcuuccagua cagccacaag      120

ccccugccgu ggaccugggu ccgguccuac gaguucacca gcaacuccug cagccagcgc      180

gccgugaucu ucaccacgaa gcgggggaag aaggugugca cccacccccg caagaagugg      240

guccagaagu acaucucccu gcucaagacc cccaagcagc uguga                      285


<210>  4972
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL26__Homo_sapiens__AAD15411

<400>  4972
augaugggcc ucucccucgc cuccgccguc cuccucgccu cccuccucuc ccuccaccuc       60

ggcaccgcca cccgcggcuc cgacaucucc aagaccugcu gcuuccagua cucccacaag      120

ccccuccccu ggaccugggu ccgcuccuac gaguucaccu ccaacuccug cucccagcgc      180

gccgucaucu ucaccaccaa gcgcggcaag aaggucugca cccacccccg caagaagugg      240

guccagaagu acaucucccu ccucaagacc cccaagcagc ucuga                      285


<210>  4973
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL26__Homo_sapiens__AAD15411

<400>  4973
augaugggcc ugagccucgc cuccgcugug cuucuggcau cuuuguuauc acugcaccua       60

gggaccgcca caagaggaag ugacaucagc aagacuugcu guuuccagua cucccauaaa      120

ccccucccuu ggacgugggu caggucuuau gaguuuaccu cgaacucaug cagccaacgg      180

gcgguuauuu ucacaacuaa gcgcgguaaa aaggugugua cccacccacg aaagaaaugg      240

guacagaagu acauaagucu gcuuaaaaca ccgaagcagc uguga                      285


<210>  4974
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL26__Homo_sapiens__AAD15411

<400>  4974
augaugggcc ugagccuggc cagcgccgug cugcuggcca gccugcugag ccugcaccug       60

ggcaccgcca ccagaggcag cgacaucagc aagaccugcu gcuuccagua cagccacaag      120

ccccugcccu ggaccugggu gagaagcuac gaguucacca gcaacagcug cagccagaga      180

gccgugaucu ucaccaccaa gagaggcaag aaggugugca cccaccccag aaagaagugg      240

gugcagaagu acaucagccu gcugaagacc cccaagcagc uguga                      285


<210>  4975
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL26__Homo_sapiens__AAD15411

<400>  4975
augaugggcc ugagccucgc cuccgcugug cugcuugccu cucugcucag ccugcaccuu       60

gggaccgcga caagaggauc cgacaucucu aagacgugcu guuuccagua cagccauaaa      120

ccccugccuu ggaccugggu ccgguccuau gaguuuacau cuaacagcug cucccaacgc      180

gcuguuauuu ucaccacaaa gagaggcaaa aaggugugua cccacccgcg gaaaaagugg      240

gugcagaagu acaucagccu ccugaaaaca cccaagcagc uguga                      285


<210>  4976
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL26__Homo_sapiens__AAD15411

<400>  4976
augaugggac uaucacuagc aucagcagua cuacuagcau cacuacuauc acuacaccua       60

ggaacagcaa caagaggauc agacauauca aaaacaugcu gcuuccaaua cucacacaaa      120

ccacuaccau ggacaugggu aagaucauac gaauucacau caaacucaug cucacaaaga      180

gcaguaauau ucacaacaaa aagaggaaaa aaaguaugca cacacccaag aaaaaaaugg      240

guacaaaaau acauaucacu acuaaaaaca ccaaaacaac uauaa                      285


<210>  4977
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL27__Homo_sapiens__Q5VZ77

<400>  4977

Met Lys Gly Pro Pro Thr Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ser Pro Asp Pro Thr Ala Ala Phe Leu Leu Pro Pro Ser Thr Ala 
            20                  25                  30          


Cys Cys Thr Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 
        35                  40                  45              


Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 
    50                  55                  60                  


Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 
65                  70                  75                  80  


Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 
                85                  90                  95      


His Gly Thr Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 
            100                 105                 110         






<210>  4978
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL27__Homo_sapiens__AAI48264

<400>  4978
augaaggggc ccccaaccuu cugcagccuc cugcugcugu cauugcuccu gagcccagac       60

ccuacagcag cauuccuacu gccacccagc acugccugcu guacucagcu cuaccgaaag      120

ccacucucag acaagcuacu gaggaagguc auccaggugg aacugcagga ggcugacggg      180

gacugucacc uccaggcuuu cgugcuucac cuggcucaac gcagcaucug cauccacccc      240

cagaacccca gccugucaca gugguuugag caccaagaga gaaagcucca ugggacucug      300

cccaagcuga auuuugggau gcuaaggaaa augggcuag                             339


<210>  4979
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL27__Homo_sapiens__AAI48264

<400>  4979
augaaggggc ccccgaccuu cugcagccug cuccugcugu cccuccugcu gagccccgac       60

cccaccgccg ccuuccuccu gcccccgucc acggcgugcu gcacccagcu guaccgcaag      120

ccccucagcg acaagcugcu gcggaaggug auccaggucg agcuccagga ggccgacggc      180

gacugccacc uccaggccuu cgugcugcac cuggcccagc gcuccaucug cauccacccc      240

cagaacccca gccuguccca gugguucgag caccaggagc ggaagcugca cggcacccuc      300

ccgaagcuga acuucgggau gcugcgcaag augggcuga                             339


<210>  4980
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL27__Homo_sapiens__AAI48264

<400>  4980
augaagggcc cccccaccuu cugcucccuc cuccuccucu cccuccuccu cucccccgac       60

cccaccgccg ccuuccuccu cccccccucc accgccugcu gcacccagcu cuaccgcaag      120

ccccucuccg acaagcuccu ccgcaagguc auccaggucg agcuccagga ggccgacggc      180

gacugccacc uccaggccuu cguccuccac cucgcccagc gcuccaucug cauccacccc      240

cagaaccccu cccucuccca gugguucgag caccaggagc gcaagcucca cggcacccuc      300

cccaagcuca acuucggcau gcuccgcaag augggcuga                             339


<210>  4981
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL27__Homo_sapiens__AAI48264

<400>  4981
augaaggggc ccccuaccuu cugcagccug cuccuucugu ccuuguuacu gucuccagac       60

ccgacagccg cuuuucuacu gcccccuuca acugcauguu gcacgcagcu guacagaaaa      120

ccacuuagug auaagcuguu gaggaaagug auccaagucg agcuccagga agccgacggc      180

gauugucacc uccaggcguu cguucugcau cucgcucagc ggagcauuug cauacacccc      240

caaaacccuu ccuuaucuca gugguuugag caucaggaac gcaagcugca cggaacccuu      300

ccaaaauuga auuucgguau gcugcgaaag augggcuga                             339


<210>  4982
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL27__Homo_sapiens__AAI48264

<400>  4982
augaagggcc cccccaccuu cugcagccug cugcugcuga gccugcugcu gagccccgac       60

cccaccgccg ccuuccugcu gccccccagc accgccugcu gcacccagcu guacagaaag      120

ccccugagcg acaagcugcu gagaaaggug auccaggugg agcugcagga ggccgacggc      180

gacugccacc ugcaggccuu cgugcugcac cuggcccaga gaagcaucug cauccacccc      240

cagaacccca gccugagcca gugguucgag caccaggaga gaaagcugca cggcacccug      300

cccaagcuga acuucggcau gcugagaaag augggcuga                             339


<210>  4983
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL27__Homo_sapiens__AAI48264

<400>  4983
augaaggggc ccccuaccuu cugcagccug cuccugcuuu cccugcuccu gucuccggac       60

cccacagccg cuuuucuucu gccucccagc acggccuguu gcacccagcu cuacagaaaa      120

ccucuguccg auaagcugcu ccggaaagug auccaagucg agcugcagga agcggacggc      180

gauugucacc uucaggcuuu cguucugcau cucgcccagc gcucuauuug cauccacccc      240

caaaacccua gccuguccca gugguuugag caucaggaaa gaaaacuuca cggaacacug      300

ccgaagcuca auuucggcau gcugcggaag augggguga                             339


<210>  4984
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL27__Homo_sapiens__AAI48264

<400>  4984
augaaaggac caccaacauu cugcucacua cuacuacuau cacuacuacu aucacccgac       60

ccaacagcag cauuccuauu accaccauca acagcaugcu gcacacaacu auacagaaaa      120

ccacuaucag acaaacuacu aagaaaagua auacaaguag aacuacaaga agcagacgga      180

gacugccacc uacaagcauu cguacuacac cuagcacaaa gaucaauaug cauacaccca      240

caaaacccau cacuaucaca augguucgaa caccaagaaa gaaaacuaca cggaacacua      300

ccaaaacuaa acuucggaau gcuaagaaaa augggauaa                             339


<210>  4985
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL28__Homo_sapiens__A0N0Q3

<400>  4985

Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 
1               5                   10                  15      


Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 
            20                  25                  30          


Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 
        35                  40                  45              


Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 
    50                  55                  60                  


Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 
65                  70                  75                  80  


Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 
                85                  90                  95      


Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 
            100                 105                 110         


Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
        115                 120                 125         


<210>  4986
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL28__Homo_sapiens__ABK41944

<400>  4986
augcagcaga gaggacucgc caucguggcc uuggcugucu gugcggcccu acaugccuca       60

gaagccauac uucccauugc cuccagcugu ugcacggagg uuucacauca uauuuccaga      120

aggcuccugg aaagagugaa uaugugucgc auccagagag cugaugggga uugugacuug      180

gcugcuguca uccuucaugu caagcgcaga agaaucugug ucagcccgca caaccauacu      240

guuaagcagu ggaugaaagu gcaagcugcc aagaaaaaug guaaaggaaa uguuugccac      300

aggaagaaac accauggcaa gaggaacagu aacagggcac aucaggggaa acacgaaaca      360

uacggccaua aaacuccuua uuag                                             384


<210>  4987
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL28__Homo_sapiens__ABK41944

<400>  4987
augcagcagc gcggccuggc caucguggcc cucgcggucu gcgccgcccu gcacgccagc       60

gaggccaucc ugcccaucgc guccagcugc ugcaccgagg ugucccacca caucagccgg      120

cgccuccugg agcgggugaa caugugccgc auccagcggg ccgacgggga cugcgaccug      180

gccgccguca uccuccacgu gaagcgccgg cgcaucugcg uguccccgca caaccacacc      240

gucaagcagu ggaugaaggu gcaggcggcc aagaagaacg gcaaggggaa cgugugccac      300

cggaagaagc accacggcaa gcgcaacagc aaccgggccc accaggggaa gcacgagacg      360

uacggccaca agacccccua cuga                                             384


<210>  4988
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL28__Homo_sapiens__ABK41944

<400>  4988
augcagcagc gcggccucgc caucgucgcc cucgccgucu gcgccgcccu ccacgccucc       60

gaggccaucc uccccaucgc cuccuccugc ugcaccgagg ucucccacca caucucccgc      120

cgccuccucg agcgcgucaa caugugccgc auccagcgcg ccgacggcga cugcgaccuc      180

gccgccguca uccuccacgu caagcgccgc cgcaucugcg ucucccccca caaccacacc      240

gucaagcagu ggaugaaggu ccaggccgcc aagaagaacg gcaagggcaa cgucugccac      300

cgcaagaagc accacggcaa gcgcaacucc aaccgcgccc accagggcaa gcacgagacc      360

uacggccaca agacccccua cuga                                             384


<210>  4989
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL28__Homo_sapiens__ABK41944

<400>  4989
augcagcaaa gaggccuggc caucguggcu cucgcagucu gcgccgcgcu ucacgcuagc       60

gaggccauuc ugcccauagc auccucuugu ugcaccgaag uuucacauca caucaguagg      120

cgguuguuag agcgcgugaa caugugucgu auucagcgag ccgacgggga uugcgaccug      180

gcugcaguaa uccuacaugu gaagagaagg cggauuugug ucagcccuca caaucauaca      240

gugaaacagu ggaugaaggu ucaggccgcu aaaaagaacg gaaaagguaa ugugugccac      300

cgcaagaagc accauggcaa aagaaacucc aauagggccc accaagggaa gcaugaaacu      360

uacggacaca aaacgccaua uuga                                             384


<210>  4990
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL28__Homo_sapiens__ABK41944

<400>  4990
augcagcaga gaggccuggc caucguggcc cuggccgugu gcgccgcccu gcacgccagc       60

gaggccaucc ugcccaucgc cagcagcugc ugcaccgagg ugagccacca caucagcaga      120

agacugcugg agagagugaa caugugcaga auccagagag ccgacggcga cugcgaccug      180

gccgccguga uccugcacgu gaagagaaga agaaucugcg ugagccccca caaccacacc      240

gugaagcagu ggaugaaggu gcaggccgcc aagaagaacg gcaagggcaa cgugugccac      300

agaaagaagc accacggcaa gagaaacagc aacagagccc accagggcaa gcacgagacc      360

uacggccaca agacccccua cuga                                             384


<210>  4991
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL28__Homo_sapiens__ABK41944

<400>  4991
augcagcaaa gaggccuggc caucguggcu cucgccgucu gcgcggcucu gcacgccagc       60

gaggccauuc uucccaucgc uuccucuugu ugcaccgaag uuagccauca cauuucccgg      120

cgccugcucg agagagugaa caugugucgg auccagcgcg ccgacgggga uugcgaccug      180

gcugccguga uucuucaugu caagagacgg cgcaucugug ugucuccuca caaucauaca      240

guuaaacagu ggaugaaggu gcaggcggcc aaaaagaacg gaaaaggcaa ugucugccac      300

agaaagaagc accaugggaa acggaacagc aaucgcgcuc accaaggaaa gcaugaaacg      360

uacggccaca aaaccccgua uuga                                             384


<210>  4992
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL28__Homo_sapiens__ABK41944

<400>  4992
augcaacaaa gaggacuagc aauaguagca uuagcaguau gcgcagcauu acacgcgagc       60

gaagcaauac uaccaauagc aagcaguugc uguacagaag uaucacacca uauaucaaga      120

agacuauuag aaagaguaaa uauguguaga auacaaagag cagauggaga uugcgaucua      180

gcagcaguaa uauuacacgu aaaaagaaga agaauaugug uaucaccaca uaaccauaca      240

guaaaacaau ggaugaaagu acaagcagca aaaaaaaaug gaaaaggaaa uguaugucac      300

agaaaaaaac accauggaaa aagaaauagc aauagagcac accaaggaaa acacgaaaca      360

uacggacaua aaacaccaua uuaa                                             384


<210>  4993
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL28__Homo_sapiens__Q9NRJ3

<400>  4993

Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 
1               5                   10                  15      


Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 
            20                  25                  30          


Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 
        35                  40                  45              


Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 
    50                  55                  60                  


Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 
65                  70                  75                  80  


Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 
                85                  90                  95      


Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 
            100                 105                 110         


Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
        115                 120                 125         


<210>  4994
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL28__Homo_sapiens__AAF87205

<400>  4994
augcagcaga gaggacucgc caucguggcc uuggcugucu gugcggcccu acaugccuca       60

gaagccauac uucccauugc cuccagcugu ugcacggagg uuucacauca uauuuccaga      120

aggcuccugg aaagagugaa uaugugucgc auccagagag cugaugggga uugugacuug      180

gcugcuguca uccuucaugu caagcgcaga agaaucugug ucagcccgca caaccauacu      240

guuaagcagu ggaugaaagu gcaagcugcc aagaaaaaug guaaaggaaa uguuugccac      300

aggaagaaac accauggcaa gaggaacagu aacagggcac aucaggggaa acacgaaaca      360

uacggccaua aaacuccuua uuag                                             384


<210>  4995
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL28__Homo_sapiens__AAF87205

<400>  4995
augcagcagc gcggccuggc caucguggcc cucgcggucu gcgccgcccu gcacgccagc       60

gaggccaucc ugcccaucgc guccagcugc ugcaccgagg ugucccacca caucagccgg      120

cgccuccugg agcgggugaa caugugccgc auccagcggg ccgacgggga cugcgaccug      180

gccgccguca uccuccacgu gaagcgccgg cgcaucugcg uguccccgca caaccacacc      240

gucaagcagu ggaugaaggu gcaggcggcc aagaagaacg gcaaggggaa cgugugccac      300

cggaagaagc accacggcaa gcgcaacagc aaccgggccc accaggggaa gcacgagacg      360

uacggccaca agacccccua cuga                                             384


<210>  4996
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL28__Homo_sapiens__AAF87205

<400>  4996
augcagcagc gcggccucgc caucgucgcc cucgccgucu gcgccgcccu ccacgccucc       60

gaggccaucc uccccaucgc cuccuccugc ugcaccgagg ucucccacca caucucccgc      120

cgccuccucg agcgcgucaa caugugccgc auccagcgcg ccgacggcga cugcgaccuc      180

gccgccguca uccuccacgu caagcgccgc cgcaucugcg ucucccccca caaccacacc      240

gucaagcagu ggaugaaggu ccaggccgcc aagaagaacg gcaagggcaa cgucugccac      300

cgcaagaagc accacggcaa gcgcaacucc aaccgcgccc accagggcaa gcacgagacc      360

uacggccaca agacccccua cuga                                             384


<210>  4997
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL28__Homo_sapiens__AAF87205

<400>  4997
augcagcaaa gaggccuggc caucguggcu cucgcagucu gcgccgcgcu ucacgcuagc       60

gaggccauuc ugcccauagc auccucuugu ugcaccgaag uuucacauca caucaguagg      120

cgguuguuag agcgcgugaa caugugucgu auucagcgag ccgacgggga uugcgaccug      180

gcugcaguaa uccuacaugu gaagagaagg cggauuugug ucagcccuca caaucauaca      240

gugaaacagu ggaugaaggu ucaggccgcu aaaaagaacg gaaaagguaa ugugugccac      300

cgcaagaagc accauggcaa aagaaacucc aauagggccc accaagggaa gcaugaaacu      360

uacggacaca aaacgccaua uuga                                             384


<210>  4998
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL28__Homo_sapiens__AAF87205

<400>  4998
augcagcaga gaggccuggc caucguggcc cuggccgugu gcgccgcccu gcacgccagc       60

gaggccaucc ugcccaucgc cagcagcugc ugcaccgagg ugagccacca caucagcaga      120

agacugcugg agagagugaa caugugcaga auccagagag ccgacggcga cugcgaccug      180

gccgccguga uccugcacgu gaagagaaga agaaucugcg ugagccccca caaccacacc      240

gugaagcagu ggaugaaggu gcaggccgcc aagaagaacg gcaagggcaa cgugugccac      300

agaaagaagc accacggcaa gagaaacagc aacagagccc accagggcaa gcacgagacc      360

uacggccaca agacccccua cuga                                             384


<210>  4999
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL28__Homo_sapiens__AAF87205

<400>  4999
augcagcaaa gaggccuggc caucguggcu cucgccgucu gcgcggcucu gcacgccagc       60

gaggccauuc uucccaucgc uuccucuugu ugcaccgaag uuagccauca cauuucccgg      120

cgccugcucg agagagugaa caugugucgg auccagcgcg ccgacgggga uugcgaccug      180

gcugccguga uucuucaugu caagagacgg cgcaucugug ugucuccuca caaucauaca      240

guuaaacagu ggaugaaggu gcaggcggcc aaaaagaacg gaaaaggcaa ugucugccac      300

agaaagaagc accaugggaa acggaacagc aaucgcgcuc accaaggaaa gcaugaaacg      360

uacggccaca aaaccccgua uuga                                             384


<210>  5000
<211>  384
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL28__Homo_sapiens__AAF87205

<400>  5000
augcaacaaa gaggacuagc aauaguagca uuagcaguau gcgcagcauu acacgcaagc       60

gaagcaauac uaccaauagc aagcucaugc uguacagaag uaucacacca uauaucaaga      120

agacuauuag aaagaguaaa uaugugcaga auacaaagag cagauggaga cugcgaccuc      180

gcagcaguaa uauuacacgu aaaaagaaga agaauaugug uaucaccaca uaaccauaca      240

guaaaacaau ggaugaaagu acaagcagca aaaaaaaaug gaaaaggaaa uguaugucac      300

agaaaaaaac accauggaaa aagaaauagc aauagagcac accaaggaaa acacgaaaca      360

uacggacaua aaacaccaua uuaa                                             384


<210>  5001
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL2__Homo_sapiens__P13500

<400>  5001

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  5002
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL2__Homo_sapiens__AAA18102

<400>  5002
augaaagucu cugccgcccu ucugugccug cugcucauag cagccaccuu cauuccccaa       60

gggcucgcuc agccagaugc aaucaaugcc ccagucaccu gcugcuauaa cuucaccaau      120

aggaagaucu cagugcagag gcucgcgagc uauagaagaa ucaccagcag caaguguccc      180

aaagaagcug ugaucuucaa gaccauugug gccaaggaga ucugugcuga ccccaagcag      240

aaguggguuc aggauuccau ggaccaccug gacaagcaaa cccaaacucc gaagacuuga      300


<210>  5003
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL2__Homo_sapiens__AAA18102

<400>  5003
augaagguga gcgccgcccu gcucugccug cugcucaucg cggccaccuu caucccccag       60

ggccuggccc agccggacgc caucaacgcc cccgugaccu gcugcuacaa cuucacgaac      120

cgcaagaucu ccguccagcg gcuggcgagc uaccgccgga ucaccuccag caagugcccc      180

aaggaggccg ugaucuucaa gaccaucguc gccaaggaga ucugcgccga ccccaagcag      240

aagugggugc aggacuccau ggaccaccuc gacaagcaga cccagacgcc gaagaccuga      300


<210>  5004
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL2__Homo_sapiens__AAA18102

<400>  5004
augaaggucu ccgccgcccu ccucugccuc cuccucaucg ccgccaccuu caucccccag       60

ggccucgccc agcccgacgc caucaacgcc cccgucaccu gcugcuacaa cuucaccaac      120

cgcaagaucu ccguccagcg ccucgccucc uaccgccgca ucaccuccuc caagugcccc      180

aaggaggccg ucaucuucaa gaccaucguc gccaaggaga ucugcgccga ccccaagcag      240

aagugggucc aggacuccau ggaccaccuc gacaagcaga cccagacccc caagaccuga      300


<210>  5005
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL2__Homo_sapiens__AAA18102

<400>  5005
augaagguga gcgccgcucu gcucugccuu cuguugaucg cagccaccuu cauuccccag       60

ggcuuagcgc aaccugacgc uauaaacgcc ccagucacau guugcuacaa uuuuacuaac      120

agaaaaaucu ccguucagag gcuggcaucu uaucggcgca uuacgucaag uaaguguccg      180

aaagaggccg ugaucuucaa gaccauugua gcuaaagaaa ucugcgcaga ucccaagcag      240

aagugggugc aggacagcau ggaucaccua gacaaacaaa cacagacucc uaagaccuga      300


<210>  5006
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL2__Homo_sapiens__AAA18102

<400>  5006
augaagguga gcgccgcccu gcugugccug cugcugaucg ccgccaccuu caucccccag       60

ggccuggccc agcccgacgc caucaacgcc cccgugaccu gcugcuacaa cuucaccaac      120

agaaagauca gcgugcagag acuggccagc uacagaagaa ucaccagcag caagugcccc      180

aaggaggccg ugaucuucaa gaccaucgug gccaaggaga ucugcgccga ccccaagcag      240

aagugggugc aggacagcau ggaccaccug gacaagcaga cccagacccc caagaccuga      300


<210>  5007
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL2__Homo_sapiens__AAA18102

<400>  5007
augaagguga gcgccgcucu gcucugccug cuucugaucg ccgcgaccuu cauuccccag       60

ggccucgcuc aaccugacgc caucaacgcc ccggucacau guugcuacaa uuuuacgaac      120

agaaaaauuu ccguucagcg gcuggcuucu uaucgcagaa ucaccagcuc caaguguccc      180

aaagaggccg ugauuuucaa gacaaucgug gcuaaagaaa ucugcgccga uccuaagcag      240

aagugggucc aggacucuau ggaucaccuu gacaaacaaa cccagacacc caagaccuga      300


<210>  5008
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL2__Homo_sapiens__AAA18102

<400>  5008
augaaaguau cagcagcacu acuaugccua cuacuaauag cagcaacauu cauaccacaa       60

ggauuagcac aaccagacgc aauaaacgca ccaguaacau gcugcuacaa cuucacaaac      120

agaaaaauau caguacaaag acuagcauca uacagaagaa uaacaucauc aaaaugccca      180

aaagaagcag uaauauucaa aacaauagua gcaaaagaaa uaugcgcaga cccaaaacaa      240

aaauggguac aagacucaau ggaccaccua gacaaacaaa cacaaacacc aaaaacauaa      300


<210>  5009
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL3__Homo_sapiens__A0N0R1

<400>  5009

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  5010
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL3__Homo_sapiens__AAI71831

<400>  5010
augcaggucu ccacugcugc ccuugcuguc cuccucugca ccauggcucu cugcaaccag       60

uucucugcau cacuugcugc ugacacgccg accgccugcu gcuucagcua caccucccgg      120

cagauuccac agaauuucau agcugacuac uuugagacga gcagccagug cuccaagccu      180

ggugucaucu uccuaaccaa gcgaagccgg caggucugug cugaccccag ugaggagugg      240

guccagaaau augucagcga ccuggagcug agugccuga                             279


<210>  5011
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL3__Homo_sapiens__AAI71831

<400>  5011
augcagguca gcaccgccgc ccuggcggug cuccugugca ccauggcccu gugcaaccag       60

uucuccgcca gccucgccgc cgacacgccc accgcgugcu gcuucuccua caccagccgc      120

cagaucccgc agaacuucau cgccgacuac uucgagaccu ccagccagug cuccaagccc      180

ggcgugaucu uccugacgaa gcggagccgc caggugugcg ccgaccccuc cgaggagugg      240

guccagaagu acgugagcga ccuggagcuc uccgccuga                             279


<210>  5012
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL3__Homo_sapiens__AAI71831

<400>  5012
augcaggucu ccaccgccgc ccucgccguc cuccucugca ccauggcccu cugcaaccag       60

uucuccgccu cccucgccgc cgacaccccc accgccugcu gcuucuccua caccucccgc      120

cagauccccc agaacuucau cgccgacuac uucgagaccu ccucccagug cuccaagccc      180

ggcgucaucu uccucaccaa gcgcucccgc caggucugcg ccgaccccuc cgaggagugg      240

guccagaagu acgucuccga ccucgagcuc uccgccuga                             279


<210>  5013
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL3__Homo_sapiens__AAI71831

<400>  5013
augcaaguga gcaccgccgc ucuggcaguc cuccuuugca caauggcccu guguaaccag       60

uucuccgcgu cuuuggcugc cgacacuccc acggcaugcu guuuuucaua caccaguaga      120

cagaucccuc agaauuucau ugccgauuau uuugagacaa gcucccagug cucuaagcca      180

ggcguuauau ucuuaacuaa aaggucgcgg caagugugug cugacccguc agaagagugg      240

guacagaagu acgugagcga ucuggaacua agugcauga                             279


<210>  5014
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL3__Homo_sapiens__AAI71831

<400>  5014
augcagguga gcaccgccgc ccuggccgug cugcugugca ccauggcccu gugcaaccag       60

uucagcgcca gccuggccgc cgacaccccc accgccugcu gcuucagcua caccagcaga      120

cagauccccc agaacuucau cgccgacuac uucgagacca gcagccagug cagcaagccc      180

ggcgugaucu uccugaccaa gagaagcaga caggugugcg ccgaccccag cgaggagugg      240

gugcagaagu acgugagcga ccuggagcug agcgccuga                             279


<210>  5015
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL3__Homo_sapiens__AAI71831

<400>  5015
augcaaguga gcaccgccgc ucuggccguc cuccugugca caauggcgcu uuguaaccag       60

uucuccgcuu cucuggccgc cgacacgccc accgcuugcu guuuuagcua cacauccaga      120

cagaucccuc agaauuucau ugccgauuau uuugagaccu cuagccagug cuccaagccg      180

ggcguuaucu uccucacaaa acggucucgc caagugugug cugaccccag cgaagagugg      240

gugcagaagu acgucuccga ucuggaacuu agcgccuga                             279


<210>  5016
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL3__Homo_sapiens__AAI71831

<400>  5016
augcaaguau caacagcagc acuagcagua cuacuaugca caauggcacu augcaaccaa       60

uucucagcau cacuagcagc agacacacca acagcaugcu gcuucucaua cacaucaaga      120

caaauaccac aaaacuucau agcagacuac uucgaaacau caucacaaug cucaaaacca      180

ggaguaauau uccuaacaaa aagaucaaga caaguaugcg cagacccauc agaagaaugg      240

guacaaaaau acguaucaga ccuagaacua ucagcauaa                             279


<210>  5017
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL3__Homo_sapiens__P10147

<400>  5017

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  5018
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL3__Homo_sapiens__AAA35858

<400>  5018
augcaggucu ccacugcugc ccuugcuguc cuccucugca ccauggcucu cugcaaccag       60

uucucugcau cacuugcugc ugacacgccg accgccugcu gcuucagcua caccucccgg      120

cagauuccac agaauuucau agcugacuac uuugagacga gcagccagug cuccaagccc      180

ggugucaucu uccuaaccaa gcgaagccgg caggucugug cugaccccag ugaggagugg      240

guccagaaau augucagcga ccuggagcug agugccuga                             279


<210>  5019
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL3__Homo_sapiens__AAA35858

<400>  5019
augcagguca gcaccgccgc ccuggcggug cuccugugca ccauggcccu gugcaaccag       60

uucuccgcca gccucgccgc cgacacgccc accgcgugcu gcuucuccua caccagccgc      120

cagaucccgc agaacuucau cgccgacuac uucgagaccu ccagccagug cuccaagccc      180

ggcgugaucu uccugacgaa gcggagccgc caggugugcg ccgaccccuc cgaggagugg      240

guccagaagu acgugagcga ccuggagcuc uccgccuga                             279


<210>  5020
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL3__Homo_sapiens__AAA35858

<400>  5020
augcaggucu ccaccgccgc ccucgccguc cuccucugca ccauggcccu cugcaaccag       60

uucuccgccu cccucgccgc cgacaccccc accgccugcu gcuucuccua caccucccgc      120

cagauccccc agaacuucau cgccgacuac uucgagaccu ccucccagug cuccaagccc      180

ggcgucaucu uccucaccaa gcgcucccgc caggucugcg ccgaccccuc cgaggagugg      240

guccagaagu acgucuccga ccucgagcuc uccgccuga                             279


<210>  5021
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL3__Homo_sapiens__AAA35858

<400>  5021
augcaaguga gcaccgccgc ucuggcaguc cuccuuugca caauggcccu guguaaccag       60

uucuccgcgu cuuuggcugc cgacacuccc acggcaugcu guuuuucaua caccaguaga      120

cagaucccuc agaauuucau ugccgauuau uuugagacaa gcucccagug cucuaagcca      180

ggcguuauau ucuuaacuaa aaggucgcgg caagugugug cugacccguc agaagagugg      240

guacagaagu acgugagcga ucuggaacua agugcauga                             279


<210>  5022
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL3__Homo_sapiens__AAA35858

<400>  5022
augcagguga gcaccgccgc ccuggccgug cugcugugca ccauggcccu gugcaaccag       60

uucagcgcca gccuggccgc cgacaccccc accgccugcu gcuucagcua caccagcaga      120

cagauccccc agaacuucau cgccgacuac uucgagacca gcagccagug cagcaagccc      180

ggcgugaucu uccugaccaa gagaagcaga caggugugcg ccgaccccag cgaggagugg      240

gugcagaagu acgugagcga ccuggagcug agcgccuga                             279


<210>  5023
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL3__Homo_sapiens__AAA35858

<400>  5023
augcaaguga gcaccgccgc ucuggccguc cuccugugca caauggcgcu uuguaaccag       60

uucuccgcuu cucuggccgc cgacacgccc accgcuugcu guuuuagcua cacauccaga      120

cagaucccuc agaauuucau ugccgauuau uuugagaccu cuagccagug cuccaagccg      180

ggcguuaucu uccucacaaa acggucucgc caagugugug cugaccccag cgaagagugg      240

gugcagaagu acgucuccga ucuggaacuu agcgccuga                             279


<210>  5024
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL3__Homo_sapiens__AAA35858

<400>  5024
augcaaguau caacagcagc acuagcagua cuacuaugca caauggcacu augcaaccaa       60

uucucagcau cacuagcagc agacacacca acagcaugcu gcuucucaua cacaucaaga      120

caaauaccac aaaacuucau agcagacuac uucgaaacau caucacaaug cucaaaacca      180

ggaguaauau ucuuaacaaa aagaucaaga caaguaugcg cagacccauc agaagaaugg      240

guacaaaaau acguaucaga ccuagaacua ucagcauaa                             279


<210>  5025
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL4__Homo_sapiens__P13236

<400>  5025

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  5026
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL4__Homo_sapiens__AAA51576

<400>  5026
augaagcucu gcgugacugu ccugucucuc cucaugcuag uagcugccuu cugcucucca       60

gcgcucucag caccaauggg cucagacccu cccaccgccu gcugcuuuuc uuacaccgcg      120

aggaagcuuc cucgcaacuu ugugguagau uacuaugaga ccagcagccu cugcucccag      180

ccagcugugg uauuccaaac caaaagaagc aagcaagucu gugcugaucc cagugaaucc      240

uggguccagg aguacgugua ugaccuggaa cugaacuga                             279


<210>  5027
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL4__Homo_sapiens__AAA51576

<400>  5027
augaagcugu gcgugaccgu ccucagccug cugaugcucg uggccgccuu cugcuccccc       60

gcgcugagcg ccccgauggg cuccgacccg cccaccgccu gcugcuucag cuacacggcc      120

cgcaagcugc cccggaacuu cguggucgac uacuacgaga ccuccagccu cugcucccag      180

cccgccgugg uguuccagac caagcgcagc aagcaggucu gcgcggaccc cuccgagagc      240

ugggugcagg aguacgugua cgaccuggag cugaacuga                             279


<210>  5028
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL4__Homo_sapiens__AAA51576

<400>  5028
augaagcucu gcgucaccgu ccucucccuc cucaugcucg ucgccgccuu cugcuccccc       60

gcccucuccg cccccauggg cuccgacccc cccaccgccu gcugcuucuc cuacaccgcc      120

cgcaagcucc cccgcaacuu cgucgucgac uacuacgaga ccuccucccu cugcucccag      180

cccgccgucg ucuuccagac caagcgcucc aagcaggucu gcgccgaccc cuccgagucc      240

uggguccagg aguacgucua cgaccucgag cucaacuga                             279


<210>  5029
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL4__Homo_sapiens__AAA51576

<400>  5029
augaagcugu gcgugaccgu ccucagccuu cugauguugg uugccgcuuu cuguuccccc       60

gcauuaucug ccccuauggg cucagaccca ccgacagcgu gcuguuuuag uuacacugcu      120

agaaaacugc ccaggaacuu cgugguagau uauuacgaga cgagcucccu augcucucag      180

ccugccgugg ucuuucaaac caagcggucg aaacaggugu gugcagaccc aucagaaagc      240

uggguucagg aguaugugua cgaucucgaa cugaauuga                             279


<210>  5030
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL4__Homo_sapiens__AAA51576

<400>  5030
augaagcugu gcgugaccgu gcugagccug cugaugcugg uggccgccuu cugcagcccc       60

gcccugagcg cccccauggg cagcgacccc cccaccgccu gcugcuucag cuacaccgcc      120

agaaagcugc ccagaaacuu cgugguggac uacuacgaga ccagcagccu gugcagccag      180

cccgccgugg uguuccagac caagagaagc aagcaggugu gcgccgaccc cagcgagagc      240

ugggugcagg aguacgugua cgaccuggag cugaacuga                             279


<210>  5031
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL4__Homo_sapiens__AAA51576

<400>  5031
augaagcugu gcgugaccgu ccucagccug cuuaugcugg uugccgcuuu cuguuccccc       60

gcccucucug cgccuauggg cagcgacccg cccacagcuu gcuguuuuuc cuacacggcc      120

agaaaacugc cucggaacuu cgugguggau uauuacgaga ccucuagccu uugcucccag      180

cccgccgucg uguuucaaac aaagcgcucu aaacagguuu gugcugaccc uagcgaaucc      240

ugggugcagg aguaugucua cgaucuggaa cucaauuga                             279


<210>  5032
<211>  279
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL4__Homo_sapiens__AAA51576

<400>  5032
augaaacuau gcguaacagu acuaucacua cuaaugcuag uagcagcauu cugcucacca       60

gcacuaucag caccaauggg aucagaccca ccaacagcau gcugcuucuc auacacagca      120

agaaaacuac caagaaacuu cguaguagac uacuacgaaa caucaucacu augcucacaa      180

ccagcaguag uauuccaaac aaaaagauca aaacaaguau gcgcagaccc aucagaauca      240

uggguacaag aauacguaua cgaccuagaa cuaaacuaa                             279


<210>  5033
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL4__Homo_sapiens__Q7M4M2

<400>  5033

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Asn Ser Lys Pro Lys Glu Ala 
            20                  25                  30          


Ser Lys Ser Val Leu Ile Pro Val Asn Pro Gly Ser Arg Ser Thr Cys 
        35                  40                  45              


Met Thr Trp Asn 
    50          


<210>  5034
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL4__Homo_sapiens__AAX07293

<400>  5034
augaagcucu gcgugacugu ccugucucuc cucaugcuag uagcugccuu cugcucucca       60

gcgcucucag caccaaauuc caaaccaaaa gaagcaagca agucugugcu gaucccagug      120

aauccugggu ccaggaguac guguaugacc uggaacuga                             159


<210>  5035
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL4__Homo_sapiens__AAX07293

<400>  5035
augaagcugu gcgugaccgu ccucagccug cugaugcucg uggccgccuu cugcuccccc       60

gcgcugagcg ccccgaacuc caagcccaag gaggccagca aguccgugcu gauccccguc      120

aaccccggca gccgcuccac gugcaugacc uggaacuga                             159


<210>  5036
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL4__Homo_sapiens__AAX07293

<400>  5036
augaagcucu gcgucaccgu ccucucccuc cucaugcucg ucgccgccuu cugcuccccc       60

gcccucuccg cccccaacuc caagcccaag gaggccucca aguccguccu cauccccguc      120

aaccccggcu cccgcuccac cugcaugacc uggaacuga                             159


<210>  5037
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL4__Homo_sapiens__AAX07293

<400>  5037
augaagcugu gcgugaccgu ccucagccuu cugauguugg uugccgcuuu cuguuccccc       60

gcauuaucug ccccuaacuc aaaaccaaag gaggcgagua aaagcgugcu gaucccggua      120

aaucccggcu ccagaucuac augcaugacu uggaacuga                             159


<210>  5038
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL4__Homo_sapiens__AAX07293

<400>  5038
augaagcugu gcgugaccgu gcugagccug cugaugcugg uggccgccuu cugcagcccc       60

gcccugagcg cccccaacag caagcccaag gaggccagca agagcgugcu gauccccgug      120

aaccccggca gcagaagcac cugcaugacc uggaacuga                             159


<210>  5039
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL4__Homo_sapiens__AAX07293

<400>  5039
augaagcugu gcgugaccgu ccucagccug cuuaugcugg uugccgcuuu cuguuccccc       60

gcccucucug cgccuaacag caaaccgaag gaggcuucca aaucugugcu gauccccgug      120

aauccuggca gcagauccac augcaugacg uggaacuga                             159


<210>  5040
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL4__Homo_sapiens__AAX07293

<400>  5040
augaaacuau gcguaacagu acuaucacua cuaaugcuag uagcagcauu cugcucacca       60

gcacuaucag caccaaacuc aaaaccaaaa gaagcaucaa aaucaguacu aauaccagua      120

aacccaggau caagaucaac augcaugaca uggaacuaa                             159


<210>  5041
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL5__Homo_sapiens__D0EI67

<400>  5041

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  5042
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL5__Homo_sapiens__ACW84342

<400>  5042
augaaggucu ccgcggcagc ccucgcuguc auccucauug cuacugcccu cugcgcuccu       60

gcaucugccu ccccauauuc cucggacacc acacccugcu gcuuugccua cauugcccgc      120

ccacugcccc gugcccacau caaggaguau uucuacacca guggcaagug cuccaaccca      180

gcagucgucu uugucacccg aaagaaccgc caagugugug ccaacccaga gaagaaaugg      240

guucgggagu acaucaacuc uuuggagaug agcuag                                276


<210>  5043
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL5__Homo_sapiens__ACW84342

<400>  5043
augaagguga gcgccgccgc gcuggccguc auccucaucg ccaccgcccu gugcgccccc       60

gcguccgcca gcccguacuc cagcgacacc acgcccugcu gcuucgccua caucgcccgc      120

ccccugcccc gggcgcacau caaggaguac uucuacaccu ccggcaagug cagcaacccg      180

gccguggugu ucgucacccg caagaaccgc caggugugcg ccaaccccga gaagaagugg      240

gugcgggagu acaucaacuc ccucgagaug agcuga                                276


<210>  5044
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL5__Homo_sapiens__ACW84342

<400>  5044
augaaggucu ccgccgccgc ccucgccguc auccucaucg ccaccgcccu cugcgccccc       60

gccuccgccu cccccuacuc cuccgacacc acccccugcu gcuucgccua caucgcccgc      120

ccccuccccc gcgcccacau caaggaguac uucuacaccu ccggcaagug cuccaacccc      180

gccgucgucu ucgucacccg caagaaccgc caggucugcg ccaaccccga gaagaagugg      240

guccgcgagu acaucaacuc ccucgagaug uccuga                                276


<210>  5045
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL5__Homo_sapiens__ACW84342

<400>  5045
augaagguga gcgccgcugc acuggccguc auccucauug cgaccgcucu uugcgccccc       60

gcauccgccu cuccuuacuc aagugacaca acuccauguu gcuucgcuua uauagcaaga      120

ccgcugccca gggcccacau caaagaguac uuuuauacga gcggcaagug uuccaacccu      180

gcuguugugu ucguaacccg gaaaaaucgc caggugugcg ccaacccaga aaagaaaugg      240

guccgagagu acauuaauuc uuuggaaaug ucguga                                276


<210>  5046
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL5__Homo_sapiens__ACW84342

<400>  5046
augaagguga gcgccgccgc ccuggccgug auccugaucg ccaccgcccu gugcgccccc       60

gccagcgcca gccccuacag cagcgacacc acccccugcu gcuucgccua caucgccaga      120

ccccugccca gagcccacau caaggaguac uucuacacca gcggcaagug cagcaacccc      180

gccguggugu ucgugaccag aaagaacaga caggugugcg ccaaccccga gaagaagugg      240

gugagagagu acaucaacag ccuggagaug agcuga                                276


<210>  5047
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL5__Homo_sapiens__ACW84342

<400>  5047
augaagguga gcgccgcugc ccuggcgguc auccucauug cuaccgcccu gugcgccccc       60

gcuuccgccu cuccuuacag cuccgacaca acgccguguu gcuucgcuua uaucgccaga      120

ccccuuccuc gggcgcacau uaaagaguac uuuuauaccu cuggcaagug uagcaacccc      180

gccguugugu ucgugacacg caaaaauaga caggucugcg cuaacccuga aaagaaaugg      240

gugcgggagu acaucaauuc ccuggaaaug ucuuga                                276


<210>  5048
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL5__Homo_sapiens__ACW84342

<400>  5048
augaaaguaa gcgcagcagc acuagcagua auacuaauag caacagcauu augcgcacca       60

gcaagcgcaa gcccauacuc aagcgauaca acaccauguu gcuuugcaua uauagcaaga      120

ccacuaccaa gagcacacau aaaagaauac uuuuacacaa gcggaaaaug uagcaaucca      180

gcaguaguau ucguaacaag aaaaaauaga caaguaugug caaauccaga aaaaaaaugg      240

guaagagaau acauaaacuc acuagaaaug ucauaa                                276


<210>  5049
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL5__Homo_sapiens__P13501

<400>  5049

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  5050
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL5__Homo_sapiens__AAC03541

<400>  5050
augaaggucu ccgcggcagc ccucgcuguc auccucauug cuacugcccu cugcgcuccu       60

gcaucugccu ccccauauuc cucggacacc acacccugcu gcuuugccua cauugcccgc      120

ccacugcccc gugcccacau caaggaguau uucuacacca guggcaagug cuccaaccca      180

gcagucgucu uugucacccg aaagaaccgc caagugugug ccaacccaga gaagaaaugg      240

guucgggagu acaucaacuc uuuggagaug agcuag                                276


<210>  5051
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL5__Homo_sapiens__AAC03541

<400>  5051
augaagguga gcgccgccgc gcuggccguc auccucaucg ccaccgcccu gugcgccccc       60

gcguccgcca gcccguacuc cagcgacacc acgcccugcu gcuucgccua caucgcccgc      120

ccccugcccc gggcgcacau caaggaguac uucuacaccu ccggcaagug cagcaacccg      180

gccguggugu ucgucacccg caagaaccgc caggugugcg ccaaccccga gaagaagugg      240

gugcgggagu acaucaacuc ccucgagaug agcuga                                276


<210>  5052
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL5__Homo_sapiens__AAC03541

<400>  5052
augaaggucu ccgccgccgc ccucgccguc auccucaucg ccaccgcccu cugcgccccc       60

gccuccgccu cccccuacuc cuccgacacc acccccugcu gcuucgccua caucgcccgc      120

ccccuccccc gcgcccacau caaggaguac uucuacaccu ccggcaagug cuccaacccc      180

gccgucgucu ucgucacccg caagaaccgc caggucugcg ccaaccccga gaagaagugg      240

guccgcgagu acaucaacuc ccucgagaug uccuga                                276


<210>  5053
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL5__Homo_sapiens__AAC03541

<400>  5053
augaagguga gcgccgcugc acuggccguc auccucauug cgaccgcucu uugcgccccc       60

gcauccgccu cuccuuacuc aagugacaca acuccauguu gcuucgcuua uauagcaaga      120

ccgcugccca gggcccacau caaagaguac uuuuauacga gcggcaagug uuccaacccu      180

gcuguugugu ucguaacccg gaaaaaucgc caggugugcg ccaacccaga aaagaaaugg      240

guccgagagu acauuaauuc uuuggaaaug ucguga                                276


<210>  5054
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL5__Homo_sapiens__AAC03541

<400>  5054
augaagguga gcgccgccgc ccuggccgug auccugaucg ccaccgcccu gugcgccccc       60

gccagcgcca gccccuacag cagcgacacc acccccugcu gcuucgccua caucgccaga      120

ccccugccca gagcccacau caaggaguac uucuacacca gcggcaagug cagcaacccc      180

gccguggugu ucgugaccag aaagaacaga caggugugcg ccaaccccga gaagaagugg      240

gugagagagu acaucaacag ccuggagaug agcuga                                276


<210>  5055
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL5__Homo_sapiens__AAC03541

<400>  5055
augaagguga gcgccgcugc ccuggcgguc auccucauug cuaccgcccu gugcgccccc       60

gcuuccgccu cuccuuacag cuccgacaca acgccguguu gcuucgcuua uaucgccaga      120

ccccuuccuc gggcgcacau uaaagaguac uuuuauaccu cuggcaagug uagcaacccc      180

gccguugugu ucgugacacg caaaaauaga caggucugcg cuaacccuga aaagaaaugg      240

gugcgggagu acaucaauuc ccuggaaaug ucuuga                                276


<210>  5056
<211>  276
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL5__Homo_sapiens__AAC03541

<400>  5056
augaaaguaa gcgcagcagc acucgcagua auacuaauag caacagcauu augcgcacca       60

gcaagcgcaa gcccauacuc aagcgauaca acaccauguu gcuuugcaua uauagcaaga      120

ccacuaccaa gagcacacau aaaagaauac uuuuacacaa gcggaaaaug uagcaaucca      180

gcaguaguau ucguaacaag aaaaaauaga caaguaugug caaauccaga aaaaaaaugg      240

guaagagaau acauaaacuc acuagaaaug ucauaa                                276


<210>  5057
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL6__Mus_musculus__P27784

<400>  5057

Met Arg Asn Ser Lys Thr Ala Ile Ser Phe Phe Ile Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gly Leu Ile Gln Glu Met Glu Lys Glu Asp Arg 
            20                  25                  30          


Arg Tyr Asn Pro Pro Ile Ile His Gln Gly Phe Gln Asp Thr Ser Ser 
        35                  40                  45              


Asp Cys Cys Phe Ser Tyr Ala Thr Gln Ile Pro Cys Lys Arg Phe Ile 
    50                  55                  60                  


Tyr Tyr Phe Pro Thr Ser Gly Gly Cys Ile Lys Pro Gly Ile Ile Phe 
65                  70                  75                  80  


Ile Ser Arg Arg Gly Thr Gln Val Cys Ala Asp Pro Ser Asp Arg Arg 
                85                  90                  95      


Val Gln Arg Cys Leu Ser Thr Leu Lys Gln Gly Pro Arg Ser Gly Asn 
            100                 105                 110         


Lys Val Ile Ala 
        115     


<210>  5058
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL6__Mus_musculus__AAA37329

<400>  5058
augagaaacu ccaagacugc cauuucauuc uuuauccuug uggcuguccu ugggucccag       60

gcuggccuca uacaagaaau ggaaaaagaa gaucgucgcu auaacccucc aauaauucau      120

caaggcuuuc aagacacuuc uucagacugc ugcuucucuu augccacaca gaucccaugu      180

aaaagauuua uauauuauuu ccccaccagu ggugggugca ucaagccggg caucaucuuu      240

aucagcagga ggggaaccca ggucugugcc gaccccagcg aucggagagu ucagaggugc      300

cuaagcaccc ugaagcaagg cccaagaucu gggaacaagg ucauugcuug a               351


<210>  5059
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL6__Mus_musculus__AAA37329

<400>  5059
augcgcaaca gcaagaccgc caucuccuuc uucauccugg uggccguccu cggcagccag       60

gcggggcuga uccaggagau ggagaaggag gaccggcgcu acaacccgcc caucauccac      120

cagggcuucc aggacaccuc cagcgacugc ugcuucuccu acgccacgca gauccccugc      180

aagcgguuca ucuacuacuu ccccaccagc gggggcugca ucaagcccgg gaucaucuuc      240

aucucccgcc ggggcaccca ggugugcgcc gacccgagcg accgccgggu gcagcgcugc      300

cuguccaccc ucaagcaggg cccccggagc gggaacaagg ucaucgccug a               351


<210>  5060
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL6__Mus_musculus__AAA37329

<400>  5060
augcgcaacu ccaagaccgc caucuccuuc uucauccucg ucgccguccu cggcucccag       60

gccggccuca uccaggagau ggagaaggag gaccgccgcu acaacccccc caucauccac      120

cagggcuucc aggacaccuc cuccgacugc ugcuucuccu acgccaccca gauccccugc      180

aagcgcuuca ucuacuacuu ccccaccucc ggcggcugca ucaagcccgg caucaucuuc      240

aucucccgcc gcggcaccca ggucugcgcc gaccccuccg accgccgcgu ccagcgcugc      300

cucuccaccc ucaagcaggg cccccgcucc ggcaacaagg ucaucgccug a               351


<210>  5061
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL6__Mus_musculus__AAA37329

<400>  5061
augagaaaca gcaagaccgc caucuccuuc uuuauucugg uggcuguccu cggcucucag       60

gcagggcuua uacaagagau ggaaaaagag gacaggcggu acaauccccc uaucauucac      120

cagggauucc aggauacauc aagugacugc uguuuuagcu augccacuca gaucccaugc      180

aagcgcuuca uuuacuauuu uccgacgucc gguggcugua ucaaacccgg gauaaucuuc      240

auuucucgac guggaaccca aguuugcgcg gauccuucgg acagaagggu gcagcggugu      300

cugucaacau ugaagcaggg cccacgcagc gguaacaaag uaaucgcuug a               351


<210>  5062
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL6__Mus_musculus__AAA37329

<400>  5062
augagaaaca gcaagaccgc caucagcuuc uucauccugg uggccgugcu gggcagccag       60

gccggccuga uccaggagau ggagaaggag gacagaagau acaacccccc caucauccac      120

cagggcuucc aggacaccag cagcgacugc ugcuucagcu acgccaccca gauccccugc      180

aagagauuca ucuacuacuu ccccaccagc ggcggcugca ucaagcccgg caucaucuuc      240

aucagcagaa gaggcaccca ggugugcgcc gaccccagcg acagaagagu gcagagaugc      300

cugagcaccc ugaagcaggg ccccagaagc ggcaacaagg ugaucgccug a               351


<210>  5063
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL6__Mus_musculus__AAA37329

<400>  5063
augagaaaca gcaagaccgc caucuccuuc uuuauucugg uggcuguccu cggcucucag       60

gccgggcuga uccaagagau ggaaaaagag gaccggcgcu acaauccccc uauuauccac      120

cagggauucc aggauacaag cuccgacugc uguuuuucuu augcgacgca gauuccgugc      180

aagagauuca ucuacuauuu ucccaccagc ggcgggugua ucaaaccugg aauuaucuuc      240

auuucccggc gcggcacaca aguuugcgcu gaucccucug acagacgggu gcagcgcugu      300

cuuagcaccc ugaagcaggg gccuagaucc ggaaacaaag ugaucgccug a               351


<210>  5064
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL6__Mus_musculus__AAA37329

<400>  5064
augagaaacu caaaaacagc aauaucauuc uucauacuag uagcaguacu aggaucacaa       60

gcaggacuaa uacaagaaau ggaaaaagaa gacagaagau acaacccacc aauaauacac      120

caaggauucc aagacacauc aucagacugc ugcuucucau acgcaacaca aauaccaugc      180

aaaagauuca uauacuacuu cccaacauca ggaggaugca uaaaaccagg aauaauauuc      240

auaucaagaa gaggaacaca aguaugcgca gacccaucag acagaagagu acaaagaugc      300

cuaucaacac uaaaacaagg accaagauca ggaaacaaag uaauagcaua a               351


<210>  5065
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL7__Homo_sapiens__P80098

<400>  5065

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 
            20                  25                  30          


Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 
                85                  90                  95      


Pro Lys Leu 
            


<210>  5066
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL7__Homo_sapiens__AAH92436

<400>  5066
augaaagccu cugcagcacu ucugugucug cugcucacag cagcugcuuu cagcccccag       60

gggcuugcuc agccaguugg gauuaauacu ucaacuaccu gcugcuacag auuuaucaau      120

aagaaaaucc cuaagcagag gcuggagagc uacagaagga ccaccaguag ccacuguccc      180

cgggaagcug uaaucuucaa gaccaaacug gacaaggaga ucugugcuga ccccacacag      240

aagugggucc aggacuuuau gaagcaccug gacaagaaaa cccaaacucc aaagcuuuga      300


<210>  5067
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL7__Homo_sapiens__AAH92436

<400>  5067
augaaggcca gcgccgcgcu gcucugccug cugcucaccg ccgccgccuu cagcccccag       60

ggccuggccc agccgguggg gaucaacacc uccacgaccu gcugcuaccg cuucaucaac      120

aagaagaucc ccaagcagcg gcuggagucc uaccgccgga ccaccagcuc ccacugcccc      180

cgcgaggcgg ucaucuucaa gacgaagcuc gacaaggaga ucugcgccga ccccacccag      240

aagugggugc aggacuucau gaagcaccug gacaagaaga cccagacccc gaagcuguga      300


<210>  5068
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL7__Homo_sapiens__AAH92436

<400>  5068
augaaggccu ccgccgcccu ccucugccuc cuccucaccg ccgccgccuu cuccccccag       60

ggccucgccc agcccgucgg caucaacacc uccaccaccu gcugcuaccg cuucaucaac      120

aagaagaucc ccaagcagcg ccucgagucc uaccgccgca ccaccuccuc ccacugcccc      180

cgcgaggccg ucaucuucaa gaccaagcuc gacaaggaga ucugcgccga ccccacccag      240

aagugggucc aggacuucau gaagcaccuc gacaagaaga cccagacccc caagcucuga      300


<210>  5069
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL7__Homo_sapiens__AAH92436

<400>  5069
augaaggcca gcgcugcacu gcucugccuu cuguugaccg ccgcggcuuu cucuccccag       60

ggcuuagccc aaccuguggg gaucaacaca uccacuacgu guugcuacag auuuauuaau      120

aaaaagauac caaaacagag gcuggaguca uaucggcgca ccacaaguag ccacuguccg      180

cgagaagcag ucaucuucaa gacuaaacua gacaaggaga uuugcgccga ucccacccag      240

aaguggguuc aggacuuuau gaaacaucuc gauaagaaaa cacaaacccc uaagcuguga      300


<210>  5070
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL7__Homo_sapiens__AAH92436

<400>  5070
augaaggcca gcgccgcccu gcugugccug cugcugaccg ccgccgccuu cagcccccag       60

ggccuggccc agcccguggg caucaacacc agcaccaccu gcugcuacag auucaucaac      120

aagaagaucc ccaagcagag acuggagagc uacagaagaa ccaccagcag ccacugcccc      180

agagaggccg ugaucuucaa gaccaagcug gacaaggaga ucugcgccga ccccacccag      240

aagugggugc aggacuucau gaagcaccug gacaagaaga cccagacccc caagcuguga      300


<210>  5071
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL7__Homo_sapiens__AAH92436

<400>  5071
augaaggcca gcgcugcccu gcucugccug cuucugaccg cggcugccuu cucuccccag       60

ggccucgccc aaccuguggg gaucaacaca uccacgaccu guugcuacag auuuauuaau      120

aaaaagaucc cgaaacagcg gcuggagagc uaucgcagaa caaccuccuc ucacuguccc      180

cgggaagcug ucauuuucaa gacaaaacuu gacaaggaga ucugcgccga uccuacccag      240

aaguggguuc aggacuuuau gaaacaucug gauaagaaaa cacaaacccc caagcucuga      300


<210>  5072
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL7__Homo_sapiens__AAH92436

<400>  5072
augaaagcau cagcagcacu acuaugccua uuacuaacag cagcagcauu cucaccacaa       60

ggacuagcac aaccaguagg aauaaacaca ucaacaacau gcugcuacag auucauaaac      120

aaaaaaauac caaaacaaag acuagaauca uacagaagaa caacaucauc acacugccca      180

agagaagcag uaauauucaa aacaaaacua gacaaagaaa uaugcgcaga cccaacacaa      240

aaauggguac aagacuucau gaaacaccua gacaaaaaaa cacaaacacc aaaacuauaa      300


<210>  5073
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL7__Homo_sapiens__Q7Z7Q8

<400>  5073

Met Trp Lys Pro Met Pro Ser Pro Ser Asn Met Lys Ala Ser Ala Ala 
1               5                   10                  15      


Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala Phe Ser Pro Gln Gly Leu 
            20                  25                  30          


Ala Gln Pro Val Gly Ile Asn Thr Ser Thr Thr Cys Cys Tyr Arg Phe 
        35                  40                  45              


Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu Ser Tyr Arg Arg Thr 
    50                  55                  60                  


Thr Ser Ser His Cys Pro Arg Glu Ala Val Ile Phe Lys Thr Lys Leu 
65                  70                  75                  80  


Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys Trp Val Gln Asp Phe 
                85                  90                  95      


Met Lys His Leu Asp Lys Lys Thr Gln Thr Pro Lys Leu 
            100                 105                 


<210>  5074
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL7__Homo_sapiens__EAW80210

<400>  5074
auguggaagc ccaugcccuc acccuccaac augaaagccu cugcagcacu ucugugucug       60

cugcucacag cagcugcuuu cagcccccag gggcuugcuc agccaguugg gauuaauacu      120

ucaacuaccu gcugcuacag auuuaucaau aagaaaaucc cuaagcagag gcuggagagc      180

uacagaagga ccaccaguag ccacuguccc cgggaagcug uaaucuucaa gaccaaacug      240

gacaaggaga ucugugcuga ccccacacag aagugggucc aggacuuuau gaagcaccug      300

gacaagaaaa cccaaacucc aaagcuuuga                                       330


<210>  5075
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL7__Homo_sapiens__EAW80210

<400>  5075
auguggaagc ccaugccgag ccccuccaac augaaggcca gcgccgcgcu gcucugccug       60

cugcucaccg ccgccgccuu cagcccccag ggccuggccc agcccguggg gaucaacacc      120

uccacgaccu gcugcuaccg cuucaucaac aagaagaucc cgaagcagcg gcuggagucc      180

uaccgccgga ccaccagcuc ccacugcccc cgcgaggcgg ucaucuucaa gacgaagcuc      240

gacaaggaga ucugcgccga ccccacccag aagugggugc aggacuucau gaagcaccug      300

gacaagaaga cccagacccc caagcuguga                                       330


<210>  5076
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL7__Homo_sapiens__EAW80210

<400>  5076
auguggaagc ccaugcccuc ccccuccaac augaaggccu ccgccgcccu ccucugccuc       60

cuccucaccg ccgccgccuu cuccccccag ggccucgccc agcccgucgg caucaacacc      120

uccaccaccu gcugcuaccg cuucaucaac aagaagaucc ccaagcagcg ccucgagucc      180

uaccgccgca ccaccuccuc ccacugcccc cgcgaggccg ucaucuucaa gaccaagcuc      240

gacaaggaga ucugcgccga ccccacccag aagugggucc aggacuucau gaagcaccuc      300

gacaagaaga cccagacccc caagcucuga                                       330


<210>  5077
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL7__Homo_sapiens__EAW80210

<400>  5077
auguggaagc ccaugccuag cccauccaac augaaagccu cugcugcacu gcucugccuu       60

cuguugaccg ccgcggcuuu cucaccgcag ggcuuagccc aacccguggg gaucaauaca      120

aguacuacgu guugcuacag auuuauuaac aagaaaauac cuaagcagag gcuggagagc      180

uaucggcgca ccacauccuc ucacugucca cgagaagcag ucaucuucaa aacuaagcua      240

gacaaggaga uuugcgccga ucccacccag aaauggguuc aggacuuuau gaagcaucuc      300

gauaaaaaga cacaaacccc uaaacuguga                                       330


<210>  5078
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL7__Homo_sapiens__EAW80210

<400>  5078
auguggaagc ccaugcccag ccccagcaac augaaggcca gcgccgcccu gcugugccug       60

cugcugaccg ccgccgccuu cagcccccag ggccuggccc agcccguggg caucaacacc      120

agcaccaccu gcugcuacag auucaucaac aagaagaucc ccaagcagag acuggagagc      180

uacagaagaa ccaccagcag ccacugcccc agagaggccg ugaucuucaa gaccaagcug      240

gacaaggaga ucugcgccga ccccacccag aagugggugc aggacuucau gaagcaccug      300

gacaagaaga cccagacccc caagcuguga                                       330


<210>  5079
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL7__Homo_sapiens__EAW80210

<400>  5079
auguggaagc ccaugccuag cccguccaac augaaagccu cugcugcccu gcucugccug       60

cuucugaccg cggcugccuu cagcccccag ggccucgccc aaccuguggg gaucaauaca      120

uccacgaccu guugcuacag auuuauuaac aagaaaaucc ccaagcagcg gcuggagucu      180

uaucgcagaa caaccagcuc ccacuguccu cgggaagcug ucauuuucaa aacaaaacuu      240

gacaaggaga ucugcgccga ucccacccag aaguggguuc aggacuuuau gaagcaucug      300

gauaaaaaga cacaaacccc uaaacucuga                                       330


<210>  5080
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL7__Homo_sapiens__EAW80210

<400>  5080
auguggaaac caaugccauc accaucaaac augaaagcau cagcagcacu acuaugccua       60

cuacuaacag cagcagcauu cucaccacaa ggacuagcac aaccaguagg aauaaacaca      120

ucaacaacau gcugcuacag auucauaaac aaaaaaauac caaaacaaag acuagaauca      180

uacagaagaa caacaucauc acacugcccc agagaagcag uaauauucaa aacaaaacua      240

gacaaagaaa uaugcgcaga cccaacacaa aaauggguac aagacuucau gaaacaccua      300

gacaaaaaaa cacaaacacc aaaacuauaa                                       330


<210>  5081
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL8__Homo_sapiens__H0UIC7

<400>  5081

Met Leu Lys Leu Thr Pro Leu Pro Ser Lys Met Lys Val Ser Ala Ala 
1               5                   10                  15      


Leu Leu Cys Leu Leu Leu Met Ala Ala Thr Phe Ser Pro Gln Gly Leu 
            20                  25                  30          


Ala Gln Pro Asp Ser Val Ser Ile Pro Ile Thr Cys Cys Phe Asn Val 
        35                  40                  45              


Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu Glu Ser Tyr Thr Arg Ile 
    50                  55                  60                  


Thr Asn Ile Gln Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Lys Arg 
65                  70                  75                  80  


Gly Lys Glu Val Cys Ala Asp Pro Lys Glu Arg Trp Val Arg Asp Ser 
                85                  90                  95      


Met Lys His Leu Asp Gln Ile Phe Gln Asn Leu Lys Pro 
            100                 105                 


<210>  5082
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL8__Homo_sapiens__EAW80207

<400>  5082
augcugaagc ucacacccuu gcccuccaag augaagguuu cugcagcgcu ucugugccug       60

cugcucaugg cagccacuuu cagcccucag ggacuugcuc agccagauuc aguuuccauu      120

ccaaucaccu gcugcuuuaa cgugaucaau aggaaaauuc cuauccagag gcuggagagc      180

uacacaagaa ucaccaacau ccaauguccc aaggaagcug ugaucuucaa gaccaaacgg      240

ggcaaggagg ucugugcuga ccccaaggag agauggguca gggauuccau gaagcaucug      300

gaccaaauau uucaaaaucu gaagccauga                                       330


<210>  5083
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL8__Homo_sapiens__EAW80207

<400>  5083
augcugaagc ucaccccgcu gcccagcaag augaaggugu ccgccgcccu gcucugccug       60

cugcucaugg cggccaccuu cagcccccag ggccuggccc agcccgacuc cgucagcauc      120

cccaucacgu gcugcuucaa cgugaucaac cgcaagaucc cgauccagcg gcuggagucc      180

uacacccgca ucaccaacau ccagugcccc aaggaggccg ugaucuucaa gaccaagcgg      240

gggaaggagg ucugcgccga ccccaaggag cgcugggugc gggacagcau gaagcaccuc      300

gaccagaucu uccagaaccu gaagcccuga                                       330


<210>  5084
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL8__Homo_sapiens__EAW80207

<400>  5084
augcucaagc ucaccccccu ccccuccaag augaaggucu ccgccgcccu ccucugccuc       60

cuccucaugg ccgccaccuu cuccccccag ggccucgccc agcccgacuc cgucuccauc      120

cccaucaccu gcugcuucaa cgucaucaac cgcaagaucc ccauccagcg ccucgagucc      180

uacacccgca ucaccaacau ccagugcccc aaggaggccg ucaucuucaa gaccaagcgc      240

ggcaaggagg ucugcgccga ccccaaggag cgcugggucc gcgacuccau gaagcaccuc      300

gaccagaucu uccagaaccu caagcccuga                                       330


<210>  5085
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL8__Homo_sapiens__EAW80207

<400>  5085
augcugaagc ucacaccccu uccuagcaaa augaaggugu ccgccgcucu guugugcuua       60

cugcuaaugg cagccaccuu cucuccacag ggccucgcgc aaccggacuc agucaguauc      120

cccauuacuu guugcuuuaa cguuauaaau agaaaaaucc cuauucagag gcuggagagc      180

uacacgcgga ucaccaacau ucagugucca aaggaagcug ugaucuucaa aacaaagcgc      240

gggaaggagg uaugcgccga ucccaaagaa cgaugggugc gugacuccau gaagcaccuu      300

gaucagauau uucaaaaucu gaaaccuuga                                       330


<210>  5086
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL8__Homo_sapiens__EAW80207

<400>  5086
augcugaagc ugaccccccu gcccagcaag augaagguga gcgccgcccu gcugugccug       60

cugcugaugg ccgccaccuu cagcccccag ggccuggccc agcccgacag cgugagcauc      120

cccaucaccu gcugcuucaa cgugaucaac agaaagaucc ccauccagag acuggagagc      180

uacaccagaa ucaccaacau ccagugcccc aaggaggccg ugaucuucaa gaccaagaga      240

ggcaaggagg ugugcgccga ccccaaggag agauggguga gagacagcau gaagcaccug      300

gaccagaucu uccagaaccu gaagcccuga                                       330


<210>  5087
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL8__Homo_sapiens__EAW80207

<400>  5087
augcugaagc ucacaccccu gccuagcaaa augaaggugu ccgccgcccu ucugugccuc       60

cugcuuaugg cugcgaccuu cucuccgcag ggccuggcuc aacccgacag cgucuccauc      120

ccuauuacgu guugcuuuaa cguuaucaau agaaaaauuc ccauccagcg gcucgagucu      180

uacacccgca uuacaaacau ccaguguccu aaggaagccg ugaucuucaa aaccaagaga      240

gggaaggagg ugugcgccga ucccaaagaa cggugggucc gcgacagcau gaagcaccug      300

gaucagauuu uucaaaaucu gaaaccuuga                                       330


<210>  5088
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL8__Homo_sapiens__EAW80207

<400>  5088
augcuaaaac uaacaccacu accaucaaaa augaaaguau cagcagcacu acuaugccua       60

cuacuaaugg cagcaacauu cucaccacaa ggacuagcac aaccagacuc aguaucaaua      120

ccaauaacau gcugcuucaa cguaauaaac agaaaaauac caauacaaag acuagaauca      180

uacacaagaa uaacaaacau acaaugccca aaagaagcag uaauauucaa aacaaaaaga      240

ggaaaagaag uaugcgcaga cccaaaagaa agauggguaa gagacucaau gaaacaccua      300

gaccaaauau uccaaaaccu aaaaccauaa                                       330


<210>  5089
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL8__Homo_sapiens__P80075

<400>  5089

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210>  5090
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL8__Homo_sapiens__CAA76341

<400>  5090
augaagguuu cugcagcgcu ucugugccug cugcucaugg cagccacuuu cagcccucag       60

ggacuugcuc agccagauuc aguuuccauu ccaaucaccu gcugcuuuaa cgugaucaau      120

aggaaaauuc cuauccagag gcuggagagc uacacaagaa ucaccaacau ccaauguccc      180

aaggaagcug ugaucuucaa gaccaaacgg ggcaaggagg ucugugcuga ccccaaggag      240

agauggguca gggauuccau gaagcaucug gaccaaauau uucaaaaucu gaagccauga      300


<210>  5091
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL8__Homo_sapiens__CAA76341

<400>  5091
augaagguga gcgccgcccu gcucugccug cugcucaugg cggccaccuu cagcccccag       60

ggccuggccc agccggacuc cgucuccauc cccaucacgu gcugcuucaa cgugaucaac      120

cgcaagaucc ccauccagcg gcuggagagc uacacccgca ucaccaacau ccagugcccc      180

aaggaggccg ugaucuucaa gaccaagcgg gggaaggagg ucugcgccga cccgaaggag      240

cgcugggugc gggacuccau gaagcaccuc gaccagaucu uccagaaccu gaagcccuga      300


<210>  5092
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL8__Homo_sapiens__CAA76341

<400>  5092
augaaggucu ccgccgcccu ccucugccuc cuccucaugg ccgccaccuu cuccccccag       60

ggccucgccc agcccgacuc cgucuccauc cccaucaccu gcugcuucaa cgucaucaac      120

cgcaagaucc ccauccagcg ccucgagucc uacacccgca ucaccaacau ccagugcccc      180

aaggaggccg ucaucuucaa gaccaagcgc ggcaaggagg ucugcgccga ccccaaggag      240

cgcugggucc gcgacuccau gaagcaccuc gaccagaucu uccagaaccu caagcccuga      300


<210>  5093
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL8__Homo_sapiens__CAA76341

<400>  5093
augaagguga gcgccgcucu gcucugccuu cuguugaugg cagccaccuu cucuccccag       60

ggcuuagcgc aaccugacuc cgucucaauc ccaauuacau guugcuuuaa cguuauaaau      120

agaaaaaucc cgauucagag gcuggagagu uacacucgga ucacgaacau ucaguguccc      180

aaggaagcug ugaucuucaa aaccaagcgc gggaaagagg uaugcgccga uccuaaggaa      240

cgaugggugc gugacagcau gaagcaccua gaucagauau uucaaaaucu caaaccauga      300


<210>  5094
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL8__Homo_sapiens__CAA76341

<400>  5094
augaagguga gcgccgcccu gcugugccug cugcugaugg ccgccaccuu cagcccccag       60

ggccuggccc agcccgacag cgugagcauc cccaucaccu gcugcuucaa cgugaucaac      120

agaaagaucc ccauccagag acuggagagc uacaccagaa ucaccaacau ccagugcccc      180

aaggaggccg ugaucuucaa gaccaagaga ggcaaggagg ugugcgccga ccccaaggag      240

agauggguga gagacagcau gaagcaccug gaccagaucu uccagaaccu gaagcccuga      300


<210>  5095
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL8__Homo_sapiens__CAA76341

<400>  5095
augaagguga gcgccgcucu gcucugccug cuucugaugg ccgcgaccuu cucuccccag       60

ggccucgcuc aaccugacuc cgucagcauc ccgauuacau guugcuuuaa cguuaucaau      120

agaaaaauuc ccauccagcg gcuggagucc uacacgcgca uuaccaacau ccaguguccu      180

aaggaagccg ugaucuucaa aacaaagaga gggaaagagg ugugcgccga ucccaaggaa      240

cggugggucc gcgacucuau gaagcaccuu gaucagauuu uucaaaaucu gaaaccuuga      300


<210>  5096
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL8__Homo_sapiens__CAA76341

<400>  5096
augaaaguau cagcagcacu acuaugccua cuacuaaugg cagcaacauu cucaccacaa       60

ggacuagcac aaccagacuc aguaucaaua ccaauaacau gcugcuucaa cguaauaaac      120

agaaaaauac caauacaaag auuagaauca uacacaagaa uaacaaacau acaaugccca      180

aaagaagcag uaauauucaa aacaaaaaga ggaaaagaag uaugcgcaga cccaaaagaa      240

agauggguaa gagacucaau gaaacaccua gaccaaauau uccaaaacuu aaaaccauaa      300


<210>  5097
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CCL9__Mus_musculus__P51670

<400>  5097

Met Lys Pro Phe His Thr Ala Leu Ser Phe Leu Ile Leu Thr Thr Ala 
1               5                   10                  15      


Leu Gly Ile Trp Ala Gln Ile Thr His Ala Thr Glu Thr Lys Glu Val 
            20                  25                  30          


Gln Ser Ser Leu Lys Ala Gln Gln Gly Leu Glu Ile Glu Met Phe His 
        35                  40                  45              


Met Gly Phe Gln Asp Ser Ser Asp Cys Cys Leu Ser Tyr Asn Ser Arg 
    50                  55                  60                  


Ile Gln Cys Ser Arg Phe Ile Gly Tyr Phe Pro Thr Ser Gly Gly Cys 
65                  70                  75                  80  


Thr Arg Pro Gly Ile Ile Phe Ile Ser Lys Arg Gly Phe Gln Val Cys 
                85                  90                  95      


Ala Asn Pro Ser Asp Arg Arg Val Gln Arg Cys Ile Glu Arg Leu Glu 
            100                 105                 110         


Gln Asn Ser Gln Pro Arg Thr Tyr Lys Gln 
        115                 120         


<210>  5098
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CCL9__Mus_musculus__AAA92583

<400>  5098
augaagccuu uucauacugc ccucuccuuc cucauucuua caacugcucu uggaaucugg       60

gcccagauca cacaugcaac agagacaaaa gaaguccaga gcagucugaa ggcacagcaa      120

gggcuugaaa uugaaauguu ucacaugggc uuucaagacu cuucagauug cugccugucc      180

uauaacucac ggauucagug uucaagauuu auagguuauu uucccaccag uggugggugu      240

accaggccgg gcaucaucuu uaucagcaag aggggguucc aggucugugc caaccccagu      300

gaucggagag uucagagaug cauugaaaga uuggagcaaa acucacaacc acggaccuac      360

aaacaauaa                                                              369


<210>  5099
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CCL9__Mus_musculus__AAA92583

<400>  5099
augaagcccu uccacaccgc ccugagcuuc cucauccuga ccacggcccu gggcaucugg       60

gcgcagauca cccacgccac cgagaccaag gaggugcagu ccagccucaa ggcccagcag      120

gggcuggaga ucgagauguu ccacaugggc uuccaggacu ccagcgacug cugccugucc      180

uacaacagcc gcauccagug cucccgguuc aucggguacu ucccgacgag cggcgggugc      240

acccgccccg gcaucaucuu caucuccaag cggggcuucc aggucugcgc caaccccagc      300

gaccgccggg ugcagcgcug caucgagcgg cucgagcaga acucccagcc ccgcaccuac      360

aagcaguga                                                              369


<210>  5100
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CCL9__Mus_musculus__AAA92583

<400>  5100
augaagcccu uccacaccgc ccucuccuuc cucauccuca ccaccgcccu cggcaucugg       60

gcccagauca cccacgccac cgagaccaag gagguccagu ccucccucaa ggcccagcag      120

ggccucgaga ucgagauguu ccacaugggc uuccaggacu ccuccgacug cugccucucc      180

uacaacuccc gcauccagug cucccgcuuc aucggcuacu uccccaccuc cggcggcugc      240

acccgccccg gcaucaucuu caucuccaag cgcggcuucc aggucugcgc caaccccucc      300

gaccgccgcg uccagcgcug caucgagcgc cucgagcaga acucccagcc ccgcaccuac      360

aagcaguga                                                              369


<210>  5101
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CCL9__Mus_musculus__AAA92583

<400>  5101
augaagcccu uccacaccgc ccugagcuuu cucauccuua caacugcucu gggcauuugg       60

gcacagauaa cgcaugccac cgagacaaaa gaagugcaau ccucuuugaa ggcgcagcag      120

ggguuagaga ucgaaauguu ccacauggga uuucaggacu caagugauug cugucugagc      180

uacaacucca ggauucaaug cucuagauuc aucgguuauu uuccuacuuc gggcgggugu      240

acccggccag gaauuaucuu cauaucaaaa cgcggcuuuc aggucugcgc uaauccgagc      300

gaccgacgug uucagagaug uaucgagagg cuagaacaga acagucaacc ccggacauac      360

aagcaguga                                                              369


<210>  5102
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CCL9__Mus_musculus__AAA92583

<400>  5102
augaagcccu uccacaccgc ccugagcuuc cugauccuga ccaccgcccu gggcaucugg       60

gcccagauca cccacgccac cgagaccaag gaggugcaga gcagccugaa ggcccagcag      120

ggccuggaga ucgagauguu ccacaugggc uuccaggaca gcagcgacug cugccugagc      180

uacaacagca gaauccagug cagcagauuc aucggcuacu uccccaccag cggcggcugc      240

accagacccg gcaucaucuu caucagcaag agaggcuucc aggugugcgc caaccccagc      300

gacagaagag ugcagagaug caucgagaga cuggagcaga acagccagcc cagaaccuac      360

aagcaguga                                                              369


<210>  5103
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CCL9__Mus_musculus__AAA92583

<400>  5103
augaagcccu uccacaccgc ccugagcuuu cucauccuga caacggcucu uggcauuugg       60

gcccagauca cccaugcgac agagaccaaa gaagugcaau ccucucugaa ggcucagcag      120

gggcucgaga uugaaauguu ccacauggga uuucaggaca gcuccgauug cugucugucu      180

uacaacagca gaauccaaug cucccgguuc auuggcuauu uuccuacauc ugggggaugu      240

acccgcccgg gcaucaucuu cauuagcaaa agaggguuuc aggucugcgc caaucccucc      300

gaccggcgcg uucagagaug uaucgagcgg cuugaacaga acagccaacc ucgcacauac      360

aagcaguga                                                              369


<210>  5104
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CCL9__Mus_musculus__AAA92583

<400>  5104
augaaaccau uccacacagc acuaucauuc cuaauacuaa caacagcacu aggaauaugg       60

gcacaaauaa cacacgcaac agaaacaaaa gaaguacaau caucacuaaa agcacaacaa      120

ggacuagaaa uagaaauguu ccacauggga uuccaagacu caucagacug cugcuuauca      180

uacaacucaa gaauacaaug cucaagauuc auaggauacu ucccaacauc aggaggaugc      240

acaagaccag gaauaauauu cauaucaaaa agaggauucc aaguaugcgc aaaccccuca      300

gacagaagag uacaaagaug cauagaaaga cuagaacaaa acucacaacc aagaacauac      360

aaacaauaa                                                              369


<210>  5105
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__A0N0N7

<400>  5105

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  5106
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__ABK41928

<400>  5106
auggcuccga uaucucuguc guggcugcuc cgcuuggcca ccuucugcca ucugacuguc       60

cugcuggcug gacagcacca cggugugacg aaaugcaaca ucacgugcag caagaugaca      120

ucaaagauac cuguagcuuu gcucauccac uaucaacaga accaggcauc augcggcaaa      180

cgcgcaauca ucuuggagac gagacagcac aggcuguucu gugccgaccc gaaggagcaa      240

ugggucaagg acgcgaugca gcaucuggac cgccaggcug cugcccuaac ucgaaauggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagga ccaccccugc cgccggggga      360

auggacgagu cugugguccu ggagcccgaa gccacaggcg aaagcaguag ccuggagccg      420

acuccuucuu cccaggaagc acagagggcc cuggggaccu ccccagagcu gccgacgggc      480

gugacugguu ccucagggac caggcucccc ccgacgccaa aggcucagga uggagggccu      540

gugggcacgg agcuuuuccg agugccuccc gucuccacug ccgccacgug gcagaguucu      600

gcuccccacc aaccugggcc cagccucugg gcugaggcaa agaccucuga ggccccgucc      660

acccaggacc ccuccaccca ggccuccacu gcguccuccc cagccccaga ggagaaugcu      720

ccgucugaag gccagcgugu guggggucag ggacagagcc ccaggccaga gaacucucug      780

gagcgggagg agaugggucc cgugccagcg cacacggaug ccuuccagga cugggggccu      840

ggcagcaugg cccacgucuc uguggucccu gucuccucag aagggacccc cagcagggag      900

ccaguggcuu caggcagcug gaccccuaag gcugaggaac ccauccaugc caccauggac      960

ccccagaggc ugggcguccu uaucacuccu gucccugacg cccaggcugc cacccggagg     1020

caggcggugg ggcugcuggc cuuccuuggc cuccucuucu gccugggggu ggccauguuc     1080

accuaccaga gccuccaggg cugcccucga aagauggcag gagagauggc ggagggccuu     1140

cgcuacaucc cccggagcug ugguaguaau ucauaugucc uggugcccgu guga           1194


<210>  5107
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5107
auggccccca ucagccuguc cuggcuccug cgccuggcca ccuucugcca ccucaccgug       60

cugcuggcgg gccagcacca cggggucacg aagugcaaca ucacgugcag caagaugacc      120

uccaagaucc cgguggcccu ccugauccac uaccagcaga accaggccag cugcggcaag      180

cgggccauca uccuggagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggugaagg acgcgaugca gcaccuggac cggcaggccg ccgcccugac ccggaacggg      300

ggcaccuucg agaagcagau cggggagguc aagccccgca ccacccccgc ggccggcggc      360

auggacgagu ccguggugcu cgagccggag gccacggggg agagcuccag ccuggagccc      420

acccccucca gccaggaggc ccagcgggcc cugggcaccu cccccgagcu cccgaccggg      480

gucacgggca gcuccgggac ccgccugccg cccaccccca aggcgcagga cggcggcccc      540

guggggaccg agcuguuccg ggugccgccc gucagcacgg ccgccaccug gcaguccagc      600

gcgccccacc agcccggccc cucccucugg gccgaggcca agaccagcga ggcccccucc      660

acccaggacc ccagcacgca ggccagcacc gccuccagcc cggcccccga ggagaacgcg      720

cccuccgagg ggcagcgcgu guggggccag ggccagagcc cccggccgga gaacucccug      780

gagcgcgagg agauggggcc cgugcccgcc cacaccgacg ccuuccagga cuggggcccc      840

gggagcaugg cccacgucuc cguggugccg gucagcuccg agggcacccc cagccgggag      900

cccguggccu ccgggagcug gacgccgaag gcggaggagc ccauccacgc caccauggac      960

ccccagcgcc ugggcgugcu caucaccccc gucccggacg cccaggccgc gacccggcgc     1020

caggccgugg gccugcuggc cuuccucggg cugcuguucu gccucggcgu ggccauguuc     1080

acguaccagu cccugcaggg gugcccccgg aagauggccg gcgagauggc ggaggggcug     1140

cgcuacaucc cccggagcug cggcuccaac agcuacgucc ucgugcccgu guga           1194


<210>  5108
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5108
auggccccca ucucccucuc cuggcuccuc cgccucgcca ccuucugcca ccucaccguc       60

cuccucgccg gccagcacca cggcgucacc aagugcaaca ucaccugcuc caagaugacc      120

uccaagaucc ccgucgcccu ccucauccac uaccagcaga accaggccuc cugcggcaag      180

cgcgccauca uccucgagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggucaagg acgccaugca gcaccucgac cgccaggccg ccgcccucac ccgcaacggc      300

ggcaccuucg agaagcagau cggcgagguc aagccccgca ccacccccgc cgccggcggc      360

auggacgagu ccgucguccu cgagcccgag gccaccggcg aguccuccuc ccucgagccc      420

acccccuccu cccaggaggc ccagcgcgcc cucggcaccu cccccgagcu ccccaccggc      480

gucaccggcu ccuccggcac ccgccucccc cccaccccca aggcccagga cggcggcccc      540

gucggcaccg agcucuuccg cguccccccc gucuccaccg ccgccaccug gcaguccucc      600

gccccccacc agcccggccc cucccucugg gccgaggcca agaccuccga ggcccccucc      660

acccaggacc ccuccaccca ggccuccacc gccuccuccc ccgcccccga ggagaacgcc      720

cccuccgagg gccagcgcgu cuggggccag ggccaguccc cccgccccga gaacucccuc      780

gagcgcgagg agaugggccc cguccccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcuccaugg cccacgucuc cgucgucccc gucuccuccg agggcacccc cucccgcgag      900

cccgucgccu ccggcuccug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagcgcc ucggcguccu caucaccccc guccccgacg cccaggccgc cacccgccgc     1020

caggccgucg gccuccucgc cuuccucggc cuccucuucu gccucggcgu cgccauguuc     1080

accuaccagu cccuccaggg cugcccccgc aagauggccg gcgagauggc cgagggccuc     1140

cgcuacaucc cccgcuccug cggcuccaac uccuacgucc ucguccccgu cuga           1194


<210>  5109
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5109
auggccccca ucagccuguc cuggcuccuu agacuggcua ccuucugcca cuugacagug       60

uuacuggcag gccagcauca cggggucacu aaguguaaca uuacgugcuc uaaaaugacc      120

ucaaagauac cuguugcccu acucauccau uaccaacaga aucaggcgag uuguggaaaa      180

agggcuauua uccuggagac acggcagcac cgccuguuuu gcgccgaccc aaaggaacaa      240

ugggugaaag augcaaugca gcaucuugac cgacaggccg cugcauugac ucguaacggu      300

ggcaccuucg agaagcagau uggggaagua aagccgagaa caacccccgc cgcuggaggc      360

auggaugaga gcgugguccu cgaaccugag gccacuggug aguccucuuc gcuggaacca      420

acacccucaa gccaagaggc gcagagggca cuggggacca guccugaacu cccaacggga      480

gugacuggcu ccucuggcac ccgguuaccc ccuacaccaa aagcccagga cgggggaccg      540

guugguacug agcuguuucg cgugcccccu gucagcaccg cugccacaug gcaguccuca      600

gcaccacacc aacccggccc uagucuuugg gcugaggcca agaccagcga agcgccaucu      660

acgcaggauc ccuccacuca ggccucaaca gcaagcaguc cggcuccuga ggaaaaugcc      720

cccucugagg ggcaaagagu guggggacag ggccaguccc caaggccuga aaacagcuug      780

gagcgggagg aaaugggucc cguaccagcu cacaccgacg ccuuccagga uugggggccc      840

ggaucgaugg cacauguuuc uguggucccu guguccucag agggcacucc aagucgcgaa      900

ccgguggcca gcggcuccug gacacccaaa gcugaggaac cuauccacgc gaccauggac      960

ccacaacgac uggggguccu aauaacgccc guuccugaug cacaggccgc uaccagaagg     1020

caggccgugg gacuccuggc auuucuuggu cuguuguucu gucucggcgu agccauguuu     1080

acauaucagu cucugcaagg gugcccacgg aagauggcug gagagauggc cgagggcuua     1140

cguuacaucc cccgcagcug ugguucaaau aguuaugugc uggucccggu guga           1194


<210>  5110
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5110
auggccccca ucagccugag cuggcugcug agacuggcca ccuucugcca ccugaccgug       60

cugcuggccg gccagcacca cggcgugacc aagugcaaca ucaccugcag caagaugacc      120

agcaagaucc ccguggcccu gcugauccac uaccagcaga accaggccag cugcggcaag      180

agagccauca uccuggagac cagacagcac agacuguucu gcgccgaccc caaggagcag      240

ugggugaagg acgccaugca gcaccuggac agacaggccg ccgcccugac cagaaacggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagaa ccacccccgc cgccggcggc      360

auggacgaga gcguggugcu ggagcccgag gccaccggcg agagcagcag ccuggagccc      420

acccccagca gccaggaggc ccagagagcc cugggcacca gccccgagcu gcccaccggc      480

gugaccggca gcagcggcac cagacugccc cccaccccca aggcccagga cggcggcccc      540

gugggcaccg agcuguucag agugcccccc gugagcaccg ccgccaccug gcagagcagc      600

gccccccacc agcccggccc cagccugugg gccgaggcca agaccagcga ggcccccagc      660

acccaggacc ccagcaccca ggccagcacc gccagcagcc ccgcccccga ggagaacgcc      720

cccagcgagg gccagagagu guggggccag ggccagagcc ccagacccga gaacagccug      780

gagagagagg agaugggccc cgugcccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcagcaugg cccacgugag cguggugccc gugagcagcg agggcacccc cagcagagag      900

cccguggcca gcggcagcug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagagac ugggcgugcu gaucaccccc gugcccgacg cccaggccgc caccagaaga     1020

caggccgugg gccugcuggc cuuccugggc cugcuguucu gccugggcgu ggccauguuc     1080

accuaccaga gccugcaggg cugccccaga aagauggccg gcgagauggc cgagggccug     1140

agauacaucc ccagaagcug cggcagcaac agcuacgugc uggugcccgu guga           1194


<210>  5111
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5111
auggccccca ucagccuguc cuggcuccug agacuugcua ccuucugcca ccugacagug       60

cuccuggccg gccagcauca cggggucacg aaguguaaca uuaccugcuc uaaaaugaca      120

agcaagaucc cuguugcgcu ucugauucau uaccaacaga aucaggcuuc cuguggaaaa      180

cgggccauca uucucgagac ccgccagcac agacuguuuu gcgccgaccc gaaggaacaa      240

ugggugaaag augcuaugca gcaucuggac cggcaggccg cugcccucac acgcaacggc      300

gggaccuucg agaagcagau cggagaagug aagcccagaa caaccccugc ggccggcggg      360

auggaugagu cugucgugcu ggaacccgag gcuacgggag agagcuccuc ucuugaaccu      420

acccccagcu cccaagaggc ccagcgggcu cugggcacaa gcccugaacu cccgaccggc      480

guuacagggu cuuccggaac ccgccugccc ccuacgccca aagcccagga cggcgggccu      540

gugggaacag agcuuuuuag agugcccccg gucagcaccg cggccacaug gcagucuucc      600

gcuccucacc aacccggccc uagccugugg gccgaggcua agaccucuga agcccccucc      660

acccaggauc ccagcacaca ggccuccacg gcuucuagcc cugcgccgga ggaaaaugcc      720

cccuccgagg ggcaacgggu uuggggacag ggccagagcc cucgccccga aaacucucuc      780

gagagagagg aaaugggccc ugugcccgcu cacaccgacg ccuuccagga uugggggccg      840

ggauccaugg cccaugucag cguggugccu gucucuagcg agggcacacc cucccgggaa      900

ccuguugcuu cugggagcug gacccccaaa gccgaggaac cuauccacgc gacaauggac      960

ccccaacgcc ugggagugcu gauuaccccg gugccugaug cucaggccgc cacgagacgg     1020

caggcugucg gccuccuggc cuuucuuggg cuccuguucu gucugggagu ggcuauguuu     1080

acauaucagu cccuucaagg cugcccccgc aagauggccg gcgagauggc ggaggggcug     1140

agauacaucc cccggagcug uggaucuaau uccuauguuc ucgugccugu cuga           1194


<210>  5112
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CX3CL1__Homo_sapiens__ABK41928

<400>  5112
auggcaccua uaagucucag uuggcuacua cgacucgcca cauuuuguca uuuaacagua       60

cuacuagcag gacaacauca uggaguaaca aaauguaaca uaacaugcuc aaaaaugaca      120

ucaaaaauac caguagcauu auuaauacau uaccaacaaa aucaggcuuc auguggaaaa      180

cgagcaauaa uacuagaaac acgucaacau agacuuuuuu gugcagaucc aaaagaacaa      240

ugggucaaag acgcaaugca acauuuagau agacaagcag cagcacuaac aagaaacggc      300

ggaacauuug aaaaacaaau aggagaagua aaaccuagaa caacaccagc agcagguggc      360

auggaugaau cuguaguacu agaaccagaa gcaacaggag aaucaucaag uuuagaacca      420

acaccaaguu cucaagaagc acaaagagcc cuaggaacaa guccagaacu accaacagga      480

guaacaggaa guucaggaac aagacuucca ccaacuccua aagcacaaga uggaggacca      540

guagguacag aacuauucag aguaccacca guaucaacag cugcaacaug gcaaucaagu      600

gccccucacc aaccagggcc aucacuaugg gcugaagcga aaacuucaga agcaccuucu      660

acacaagacc cuucuacuca agcaucaacc gcauccagcc cagcaccaga agaaaacgca      720

ccaucggaag gucaaagagu auggggacaa ggacaaucac caagacccga aaacucacua      780

gaaagagaag aaaugggacc agucccagca cauacugaug cuuuucaaga uuggggacca      840

ggaagcaugg cccauguauc agucguacca guaucaagug aaggaacacc aagcagagaa      900

ccaguagcaa guggaucaug gaccccuaaa gcugaagaac caauacaugc uacaauggac      960

ccacaaagau uaggaguauu aauuacaccu guucccgaug cacaagccgc aacuagaaga     1020

caagcaguug gacucuuagc auuuuuggga uuacucuucu guuuaggagu agcuauguuu     1080

acauaucaau cauuacaagg auguccacga aaaauggcag gcgaaauggc agaaggauua     1140

agauauauac ccagaucaug ugguucaaau ucauacguau uaguaccagu auaa           1194


<210>  5113
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__P78423

<400>  5113

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  5114
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__AAB49679

<400>  5114
auggcuccga uaucucuguc guggcugcuc cgcuuggcca ccuucugcca ucugacuguc       60

cugcuggcug gacagcacca cggugugacg aaaugcaaca ucacgugcag caagaugaca      120

ucaaagauac cuguagcuuu gcucauccac uaucaacaga accaggcauc augcggcaaa      180

cgcgcaauca ucuuggagac gagacagcac aggcuguucu gugccgaccc gaaggagcaa      240

ugggucaagg acgcgaugca gcaucuggac cgccaggcug cugcccuaac ucgaaauggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagga ccaccccugc cgccggggga      360

auggacgagu cugugguccu ggagcccgaa gccacaggcg aaagcaguag ccuggagccg      420

acuccuucuu cccaggaagc acagagggcc cuggggaccu ccccagagcu gccgacgggc      480

gugacugguu ccucagggac caggcucccc ccgacgccaa aggcucagga uggagggccu      540

gugggcacgg agcuuuuccg agugccuccc gucuccacug ccgccacgug gcagaguucu      600

gcuccccacc aaccugggcc cagccucugg gcugaggcaa agaccucuga ggccccgucc      660

acccaggacc ccuccaccca ggccuccacu gcguccuccc cagccccaga ggagaaugcu      720

ccgucugaag gccagcgugu guggggucag ggacagagcc ccaggccaga gaacucucug      780

gagcgggagg agaugggucc cgugccagcg cacacggaug ccuuccagga cugggggccu      840

ggcagcaugg cccacgucuc uguggucccu gucuccucag aagggacccc cagcagggag      900

ccaguggcuu caggcagcug gaccccuaag gcugaggaac ccauccaugc caccauggac      960

ccccagaggc ugggcguccu uaucacuccu gucccugacg cccaggcugc cacccggagg     1020

caggcggugg ggcugcuggc cuuccuuggc cuccucuucu gccugggggu ggccauguuc     1080

accuaccaga gccuccaggg cugcccucga aagauggcag gagagauggc ggagggccuu     1140

cgcuacaucc cccggagcug ugguaguaau ucauaugucc uggugcccgu guga           1194


<210>  5115
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5115
auggccccca ucagccuguc cuggcuccug cgccuggcca ccuucugcca ccucaccgug       60

cugcuggcgg gccagcacca cggggucacg aagugcaaca ucacgugcag caagaugacc      120

uccaagaucc cgguggcccu ccugauccac uaccagcaga accaggccag cugcggcaag      180

cgggccauca uccuggagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggugaagg acgcgaugca gcaccuggac cggcaggccg ccgcccugac ccggaacggg      300

ggcaccuucg agaagcagau cggggagguc aagccccgca ccacccccgc ggccggcggc      360

auggacgagu ccguggugcu cgagccggag gccacggggg agagcuccag ccuggagccc      420

acccccucca gccaggaggc ccagcgggcc cugggcaccu cccccgagcu cccgaccggg      480

gucacgggca gcuccgggac ccgccugccg cccaccccca aggcgcagga cggcggcccc      540

guggggaccg agcuguuccg ggugccgccc gucagcacgg ccgccaccug gcaguccagc      600

gcgccccacc agcccggccc cucccucugg gccgaggcca agaccagcga ggcccccucc      660

acccaggacc ccagcacgca ggccagcacc gccuccagcc cggcccccga ggagaacgcg      720

cccuccgagg ggcagcgcgu guggggccag ggccagagcc cccggccgga gaacucccug      780

gagcgcgagg agauggggcc cgugcccgcc cacaccgacg ccuuccagga cuggggcccc      840

gggagcaugg cccacgucuc cguggugccg gucagcuccg agggcacccc cagccgggag      900

cccguggccu ccgggagcug gacgccgaag gcggaggagc ccauccacgc caccauggac      960

ccccagcgcc ugggcgugcu caucaccccc gucccggacg cccaggccgc gacccggcgc     1020

caggccgugg gccugcuggc cuuccucggg cugcuguucu gccucggcgu ggccauguuc     1080

acguaccagu cccugcaggg gugcccccgg aagauggccg gcgagauggc ggaggggcug     1140

cgcuacaucc cccggagcug cggcuccaac agcuacgucc ucgugcccgu guga           1194


<210>  5116
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5116
auggccccca ucucccucuc cuggcuccuc cgccucgcca ccuucugcca ccucaccguc       60

cuccucgccg gccagcacca cggcgucacc aagugcaaca ucaccugcuc caagaugacc      120

uccaagaucc ccgucgcccu ccucauccac uaccagcaga accaggccuc cugcggcaag      180

cgcgccauca uccucgagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggucaagg acgccaugca gcaccucgac cgccaggccg ccgcccucac ccgcaacggc      300

ggcaccuucg agaagcagau cggcgagguc aagccccgca ccacccccgc cgccggcggc      360

auggacgagu ccgucguccu cgagcccgag gccaccggcg aguccuccuc ccucgagccc      420

acccccuccu cccaggaggc ccagcgcgcc cucggcaccu cccccgagcu ccccaccggc      480

gucaccggcu ccuccggcac ccgccucccc cccaccccca aggcccagga cggcggcccc      540

gucggcaccg agcucuuccg cguccccccc gucuccaccg ccgccaccug gcaguccucc      600

gccccccacc agcccggccc cucccucugg gccgaggcca agaccuccga ggcccccucc      660

acccaggacc ccuccaccca ggccuccacc gccuccuccc ccgcccccga ggagaacgcc      720

cccuccgagg gccagcgcgu cuggggccag ggccaguccc cccgccccga gaacucccuc      780

gagcgcgagg agaugggccc cguccccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcuccaugg cccacgucuc cgucgucccc gucuccuccg agggcacccc cucccgcgag      900

cccgucgccu ccggcuccug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagcgcc ucggcguccu caucaccccc guccccgacg cccaggccgc cacccgccgc     1020

caggccgucg gccuccucgc cuuccucggc cuccucuucu gccucggcgu cgccauguuc     1080

accuaccagu cccuccaggg cugcccccgc aagauggccg gcgagauggc cgagggccuc     1140

cgcuacaucc cccgcuccug cggcuccaac uccuacgucc ucguccccgu cuga           1194


<210>  5117
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5117
auggccccca ucagccuguc cuggcuccuu agacuggcua ccuucugcca cuugacagug       60

uuacuggcag gccagcauca cggggucacu aaguguaaca uuacgugcuc uaaaaugacc      120

ucaaagauac cuguugcccu acucauccau uaccaacaga aucaggcgag uuguggaaaa      180

agggcuauua uccuggagac acggcagcac cgccuguuuu gcgccgaccc aaaggaacaa      240

ugggugaaag augcaaugca gcaucuugac cgacaggccg cugcauugac ucguaacggu      300

ggcaccuucg agaagcagau uggggaagua aagccgagaa caacccccgc cgcuggaggc      360

auggaugaga gcgugguccu cgaaccugag gccacuggug aguccucuuc gcuggaacca      420

acacccucaa gccaagaggc gcagagggca cuggggacca guccugaacu cccaacggga      480

gugacuggcu ccucuggcac ccgguuaccc ccuacaccaa aagcccagga cgggggaccg      540

guugguacug agcuguuucg cgugcccccu gucagcaccg cugccacaug gcaguccuca      600

gcaccacacc aacccggccc uagucuuugg gcugaggcca agaccagcga agcgccaucu      660

acgcaggauc ccuccacuca ggccucaaca gcaagcaguc cggcuccuga ggaaaaugcc      720

cccucugagg ggcaaagagu guggggacag ggccaguccc caaggccuga aaacagcuug      780

gagcgggagg aaaugggucc cguaccagcu cacaccgacg ccuuccagga uugggggccc      840

ggaucgaugg cacauguuuc uguggucccu guguccucag agggcacucc aagucgcgaa      900

ccgguggcca gcggcuccug gacacccaaa gcugaggaac cuauccacgc gaccauggac      960

ccacaacgac uggggguccu aauaacgccc guuccugaug cacaggccgc uaccagaagg     1020

caggccgugg gacuccuggc auuucuuggu cuguuguucu gucucggcgu agccauguuu     1080

acauaucagu cucugcaagg gugcccacgg aagauggcug gagagauggc cgagggcuua     1140

cguuacaucc cccgcagcug ugguucaaau aguuaugugc uggucccggu guga           1194


<210>  5118
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5118
auggccccca ucagccugag cuggcugcug agacuggcca ccuucugcca ccugaccgug       60

cugcuggccg gccagcacca cggcgugacc aagugcaaca ucaccugcag caagaugacc      120

agcaagaucc ccguggcccu gcugauccac uaccagcaga accaggccag cugcggcaag      180

agagccauca uccuggagac cagacagcac agacuguucu gcgccgaccc caaggagcag      240

ugggugaagg acgccaugca gcaccuggac agacaggccg ccgcccugac cagaaacggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagaa ccacccccgc cgccggcggc      360

auggacgaga gcguggugcu ggagcccgag gccaccggcg agagcagcag ccuggagccc      420

acccccagca gccaggaggc ccagagagcc cugggcacca gccccgagcu gcccaccggc      480

gugaccggca gcagcggcac cagacugccc cccaccccca aggcccagga cggcggcccc      540

gugggcaccg agcuguucag agugcccccc gugagcaccg ccgccaccug gcagagcagc      600

gccccccacc agcccggccc cagccugugg gccgaggcca agaccagcga ggcccccagc      660

acccaggacc ccagcaccca ggccagcacc gccagcagcc ccgcccccga ggagaacgcc      720

cccagcgagg gccagagagu guggggccag ggccagagcc ccagacccga gaacagccug      780

gagagagagg agaugggccc cgugcccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcagcaugg cccacgugag cguggugccc gugagcagcg agggcacccc cagcagagag      900

cccguggcca gcggcagcug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagagac ugggcgugcu gaucaccccc gugcccgacg cccaggccgc caccagaaga     1020

caggccgugg gccugcuggc cuuccugggc cugcuguucu gccugggcgu ggccauguuc     1080

accuaccaga gccugcaggg cugccccaga aagauggccg gcgagauggc cgagggccug     1140

agauacaucc ccagaagcug cggcagcaac agcuacgugc uggugcccgu guga           1194


<210>  5119
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5119
auggccccca ucagccuguc cuggcuccug agacuugcua ccuucugcca ccugacagug       60

cuccuggccg gccagcauca cggggucacg aaguguaaca uuaccugcuc uaaaaugaca      120

agcaagaucc cuguugcgcu ucugauucau uaccaacaga aucaggcuuc cuguggaaaa      180

cgggccauca uucucgagac ccgccagcac agacuguuuu gcgccgaccc gaaggaacaa      240

ugggugaaag augcuaugca gcaucuggac cggcaggccg cugcccucac acgcaacggc      300

gggaccuucg agaagcagau cggagaagug aagcccagaa caaccccugc ggccggcggg      360

auggaugagu cugucgugcu ggaacccgag gcuacgggag agagcuccuc ucuugaaccu      420

acccccagcu cccaagaggc ccagcgggcu cugggcacaa gcccugaacu cccgaccggc      480

guuacagggu cuuccggaac ccgccugccc ccuacgccca aagcccagga cggcgggccu      540

gugggaacag agcuuuuuag agugcccccg gucagcaccg cggccacaug gcagucuucc      600

gcuccucacc aacccggccc uagccugugg gccgaggcua agaccucuga agcccccucc      660

acccaggauc ccagcacaca ggccuccacg gcuucuagcc cugcgccgga ggaaaaugcc      720

cccuccgagg ggcaacgggu uuggggacag ggccagagcc cucgccccga aaacucucuc      780

gagagagagg aaaugggccc ugugcccgcu cacaccgacg ccuuccagga uugggggccg      840

ggauccaugg cccaugucag cguggugccu gucucuagcg agggcacacc cucccgggaa      900

ccuguugcuu cugggagcug gacccccaaa gccgaggaac cuauccacgc gacaauggac      960

ccccaacgcc ugggagugcu gauuaccccg gugccugaug cucaggccgc cacgagacgg     1020

caggcugucg gccuccuggc cuuucuuggg cuccuguucu gucugggagu ggcuauguuu     1080

acauaucagu cccuucaagg cugcccccgc aagauggccg gcgagauggc ggaggggcug     1140

agauacaucc cccggagcug uggaucuaau uccuauguuc ucgugccugu cuga           1194


<210>  5120
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CX3CL1__Homo_sapiens__AAB49679

<400>  5120
auggcaccaa uuucacuaag cuggcuauua agauuagcaa cauuuuguca uuuaaccgua       60

cuacucgcag gacaacauca cggaguaaca aaaugcaaca uaacauguuc uaaaaugaca      120

ucuaaaauac caguagcacu uuuaauacac uaucaacaaa aucaagcauc auguggaaaa      180

cgcgcaauaa uacuagaaac cagacaacau cguuuauuuu gcgcagaccc aaaagaacaa      240

uggguaaaag augcaaugca acauuuagau agacaagcag cagcauuaac aagaaaugga      300

gguacauuug aaaaacaaau aggagaagua aaaccuagaa caacaccugc agcaggaggc      360

auggaugaau caguaguauu agaaccagaa gcaacaggcg aaaguaguuc auuagaacca      420

acaccaagua gucaagaagc acaaagagca uuaggaacau caccagaauu accaaccggc      480

guaacgggau cgucaggaac acguuuacca ccaacaccaa aagcacaaga uggcggacca      540

guaggcacag aauuauucag aguuccacca guuaguacug cagcaaccug gcaaucuagc      600

gccccacauc aaccaggucc aucccuaugg gcagaagcca aaacaagcga agcuccauca      660

acacaagauc ccucaacaca agcaucaaca gcaaguucuc ccgcaccaga agaaaaugcu      720

ccaagugaag gacagcgagu auggggacaa ggacaauccc caagaccaga aaauucuuua      780

gaaagagaag aaaugggacc aguaccagcu cauacagaug cauuccaaga cuggggacca      840

ggaucaaugg cucaugucuc uguagucccu guaaguucag aaggaacacc aucaagagaa      900

ccaguagcau ccggaagcug gacaccaaaa gcagaagagc caauacaugc uacaauggau      960

ccgcaacgcc uaggaguucu aauuacaccu guaccagaug cacaagcagc uacaagacga     1020

caagcaguug gauuacuagc auuuuuagga cuacuauuuu gucuaggagu agcaauguuc     1080

acauaucaau cuuuacaagg auguccaaga aagauggcag gagaaauggc agaaggauua     1140

agauacauac ccagauccug uggaaguaac ucauauguau uaguaccagu auaa           1194


<210>  5121
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__Q6I9S9

<400>  5121

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Pro Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  5122
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CX3CL1__Homo_sapiens__CAG33707

<400>  5122
auggcuccga uaucucuguc guggcugcuc cgcuuggcca ccuucugcca ucugacuguc       60

cugcuggcug gacagcacca cggugugacg aaaugcaaca ucacgugcag caagaugaca      120

ucaaagauac cuguagcuuu gcucauccac uaucaacaga accaggcauc augcggcaaa      180

cgcgcaauca ucuuggagac gagacagcac aggcuguucu gugccgaccc gaaggagcaa      240

ugggucaagg acgcgaugca gcaucuggac cgccaggcug cugcccuaac ucgaaauggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagga ccaccccugc cgccggggga      360

auggacgagu cugugguccu ggagcccgaa gccacaggcg aaagcaguag cccggagccg      420

acuccuucuu cccaggaagc acagagggcc cuggggaccu ccccagagcu gccgacgggc      480

gugacugguu ccucagggac caggcucccc ccgacgccaa aggcucagga uggagggccu      540

gugggcacgg agcuuuuccg agugccuccc gucuccacug ccgccacgug gcagaguucu      600

gcuccccacc aaccugggcc cagccucugg gcugaggcaa agaccucuga ggccccgucc      660

acccaggacc ccuccaccca ggccuccacu gcguccuccc cagccccaga ggagaaugcu      720

ccgucugaag gccagcgugu guggggucag ggacagagcc ccaggccaga gaacucucug      780

gagcgggagg agaugggucc cgugccagcg cacacggaug ccuuccagga cugggggccu      840

ggcagcaugg cccacgucuc uguggucccu gucuccucag aagggacccc cagcagggag      900

ccaguggcuu caggcagcug gaccccuaag gcugaggaac ccauccaugc caccauggac      960

ccccagaggc ugggcguccu uaucacuccu gucccugacg cccaggcugc cacccggagg     1020

caggcggugg ggcugcuggc cuuccuuggc cuccucuucu gccugggggu ggccauguuc     1080

accuaccaga gccuccaggg cugcccucga aagauggcag gagagauggc ggagggccuu     1140

cgcuacaucc cccggagcug ugguaguaau ucauaugucc uggugcccgu uuaa           1194


<210>  5123
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5123
auggccccca ucagccuguc cuggcuccug cgccuggcca ccuucugcca ccucaccgug       60

cugcuggcgg gccagcacca cggggucacg aagugcaaca ucacgugcag caagaugacc      120

uccaagaucc cgguggcccu ccugauccac uaccagcaga accaggccag cugcggcaag      180

cgggccauca uccuggagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggugaagg acgcgaugca gcaccuggac cggcaggccg ccgcccugac ccggaacggg      300

ggcaccuucg agaagcagau cggggagguc aagccccgca ccacccccgc ggccggcggc      360

auggacgagu ccguggugcu cgagccggag gccacggggg agagcuccag ccccgagccc      420

acccccucca gccaggaggc ccagcgggcc cugggcaccu ccccggagcu gcccaccggg      480

gucacgggca gcuccgggac ccgccucccg cccaccccca aggcgcagga cggcggcccc      540

guggggaccg agcuguuccg ggugccgccc gucagcacgg ccgccaccug gcaguccagc      600

gcgccccacc agcccggccc cucccugugg gccgaggcca agaccagcga ggcccccucc      660

acccaggacc cgagcacgca ggccagcacc gccuccagcc ccgcccccga ggagaacgcg      720

cccuccgagg ggcagcgcgu guggggccag ggccagagcc cgcggcccga gaacucccuc      780

gagcgcgagg agauggggcc cgugcccgcc cacaccgacg ccuuccagga cuggggcccg      840

gggagcaugg cccacgucuc cguggugccc gucagcuccg agggcacccc cagccgggag      900

ccgguggccu ccgggagcug gacgcccaag gcggaggagc ccauccacgc caccauggac      960

ccccagcgcc ugggcgugcu gaucaccccg guccccgacg cccaggccgc gacccggcgc     1020

caggccgugg gccuccuggc cuuccugggg cuccuguucu gccugggcgu ggccauguuc     1080

acguaccagu cccuccaggg gugcccccgg aagauggccg gcgagauggc ggaggggcug     1140

cgcuacaucc cccggagcug cggcuccaac agcuacgucc uggugccggu guga           1194


<210>  5124
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5124
auggccccca ucucccucuc cuggcuccuc cgccucgcca ccuucugcca ccucaccguc       60

cuccucgccg gccagcacca cggcgucacc aagugcaaca ucaccugcuc caagaugacc      120

uccaagaucc ccgucgcccu ccucauccac uaccagcaga accaggccuc cugcggcaag      180

cgcgccauca uccucgagac ccgccagcac cgccucuucu gcgccgaccc caaggagcag      240

ugggucaagg acgccaugca gcaccucgac cgccaggccg ccgcccucac ccgcaacggc      300

ggcaccuucg agaagcagau cggcgagguc aagccccgca ccacccccgc cgccggcggc      360

auggacgagu ccgucguccu cgagcccgag gccaccggcg aguccuccuc ccccgagccc      420

acccccuccu cccaggaggc ccagcgcgcc cucggcaccu cccccgagcu ccccaccggc      480

gucaccggcu ccuccggcac ccgccucccc cccaccccca aggcccagga cggcggcccc      540

gucggcaccg agcucuuccg cguccccccc gucuccaccg ccgccaccug gcaguccucc      600

gccccccacc agcccggccc cucccucugg gccgaggcca agaccuccga ggcccccucc      660

acccaggacc ccuccaccca ggccuccacc gccuccuccc ccgcccccga ggagaacgcc      720

cccuccgagg gccagcgcgu cuggggccag ggccaguccc cccgccccga gaacucccuc      780

gagcgcgagg agaugggccc cguccccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcuccaugg cccacgucuc cgucgucccc gucuccuccg agggcacccc cucccgcgag      900

cccgucgccu ccggcuccug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagcgcc ucggcguccu caucaccccc guccccgacg cccaggccgc cacccgccgc     1020

caggccgucg gccuccucgc cuuccucggc cuccucuucu gccucggcgu cgccauguuc     1080

accuaccagu cccuccaggg cugcccccgc aagauggccg gcgagauggc cgagggccuc     1140

cgcuacaucc cccgcuccug cggcuccaac uccuacgucc ucguccccgu cuga           1194


<210>  5125
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5125
auggccccca ucagccuguc cuggcuccuu agacuggcua ccuucugcca cuugacagug       60

uuacuggcag gccagcauca cggggucacu aaguguaaca uuacgugcuc uaaaaugacc      120

ucaaagauac cuguugcccu acucauccau uaccaacaga aucaggcgag uuguggaaaa      180

agggcuauua uccuggagac acggcagcac cgccuguuuu gcgccgaccc aaaggaacaa      240

ugggugaaag augcaaugca gcaucuugac cgacaggccg cugcauugac ucguaacggu      300

ggcaccuucg agaagcagau uggggaagua aagccgagaa caacccccgc cgcuggaggc      360

auggaugaga gcgugguccu cgaaccugag gccacuggug aguccucuuc gccagaaccc      420

acaccuucaa gccaagaggc gcagagggca cuggggacca guccagaacu gcccacggga      480

gugacuggcu ccucuggcac ccggcucccu ccaacaccga aagcccagga cgggggaccc      540

guugguacug aguuauuucg cgugccucca gucagcaccg cugccacaug gcaguccuca      600

gcaccccacc aaccuggccc aagucugugg gcugaggcca agaccagcga agcgcccucu      660

acgcaggauc cguccacuca ggccucaaca gcaagcaguc cugcucccga ggaaaaugcc      720

ccaucugagg ggcaaagagu guggggacag ggccaguccc cuaggcccga aaacagccuu      780

gagcgggagg aaaugggucc aguacccgcu cacaccgacg ccuuccagga uugggggccu      840

ggaucgaugg cacauguuuc ugugguccca guguccucag agggcacucc gagucgcgaa      900

cccguggcca gcggcuccug gacaccuaaa gcugaggaac caauccacgc gaccauggac      960

ccccaacgau uggggguccu gauaacgccu guuccagaug cacaggccgc uaccagaagg     1020

caggccgugg gacuacucgc auuucugggu cuucuguucu guuugggcgu agccauguuu     1080

acauaucagu cucuccaagg gugcccccgg aagauggcug gagagauggc cgagggccug     1140

cguuacaucc cgcgcagcug ugguucaaau aguuaugugu uagucccugu guga           1194


<210>  5126
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5126
auggccccca ucagccugag cuggcugcug agacuggcca ccuucugcca ccugaccgug       60

cugcuggccg gccagcacca cggcgugacc aagugcaaca ucaccugcag caagaugacc      120

agcaagaucc ccguggcccu gcugauccac uaccagcaga accaggccag cugcggcaag      180

agagccauca uccuggagac cagacagcac agacuguucu gcgccgaccc caaggagcag      240

ugggugaagg acgccaugca gcaccuggac agacaggccg ccgcccugac cagaaacggc      300

ggcaccuucg agaagcagau cggcgaggug aagcccagaa ccacccccgc cgccggcggc      360

auggacgaga gcguggugcu ggagcccgag gccaccggcg agagcagcag ccccgagccc      420

acccccagca gccaggaggc ccagagagcc cugggcacca gccccgagcu gcccaccggc      480

gugaccggca gcagcggcac cagacugccc cccaccccca aggcccagga cggcggcccc      540

gugggcaccg agcuguucag agugcccccc gugagcaccg ccgccaccug gcagagcagc      600

gccccccacc agcccggccc cagccugugg gccgaggcca agaccagcga ggcccccagc      660

acccaggacc ccagcaccca ggccagcacc gccagcagcc ccgcccccga ggagaacgcc      720

cccagcgagg gccagagagu guggggccag ggccagagcc ccagacccga gaacagccug      780

gagagagagg agaugggccc cgugcccgcc cacaccgacg ccuuccagga cuggggcccc      840

ggcagcaugg cccacgugag cguggugccc gugagcagcg agggcacccc cagcagagag      900

cccguggcca gcggcagcug gacccccaag gccgaggagc ccauccacgc caccauggac      960

ccccagagac ugggcgugcu gaucaccccc gugcccgacg cccaggccgc caccagaaga     1020

caggccgugg gccugcuggc cuuccugggc cugcuguucu gccugggcgu ggccauguuc     1080

accuaccaga gccugcaggg cugccccaga aagauggccg gcgagauggc cgagggccug     1140

agauacaucc ccagaagcug cggcagcaac agcuacgugc uggugcccgu guga           1194


<210>  5127
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5127
auggccccca ucagccuguc cuggcuccug agacuugcua ccuucugcca ccugacagug       60

cuccuggccg gccagcauca cggggucacg aaguguaaca uuaccugcuc uaaaaugaca      120

agcaagaucc cuguugcgcu ucugauucau uaccaacaga aucaggcuuc cuguggaaaa      180

cgggccauca uucucgagac ccgccagcac agacuguuuu gcgccgaccc gaaggaacaa      240

ugggugaaag augcuaugca gcaucuggac cggcaggccg cugcccucac acgcaacggc      300

gggaccuucg agaagcagau cggagaagug aagcccagaa caaccccugc ggccggcggg      360

auggaugagu cugucgugcu ggaacccgag gcuacgggag agagcuccuc uccugaaccc      420

accccuagcu cccaagaggc ccagcgggcu cuuggcacaa gcccggaacu gcccaccggc      480

guuacagggu cuuccggaac ccgccucccu cccacgccua aagcccagga cggcgggccc      540

gugggaacag agcuguuuag agucccgccu gugagcaccg cggccacaug gcagucuucc      600

gcuccccacc aaccuggccc cagccuuugg gccgaggcua agaccucuga agcccccucc      660

acccaggauc cuagcacaca ggccuccacg gcuucuagcc cggcgcccga ggaaaaugcc      720

ccuuccgagg ggcaacgggu uuggggacag ggccagagcc cccgcccuga aaacucucug      780

gagagagagg aaaugggccc cgugccggcu cacaccgacg ccuuccagga uugggggccu      840

ggauccaugg cccaugucag cguggugccc gucucuagcg agggcacacc uucccgggaa      900

cccguugcuu cugggagcug gaccccuaaa gccgaggaac ccauccacgc gacaauggac      960

ccgcaacgcc ucggagugcu gauuaccccu gugcccgaug cucaggccgc cacgagacgg     1020

caggcugucg gccugcucgc cuuucugggg cuucuguucu gucucggagu ggcuauguuu     1080

acauaucagu cccugcaagg cugcccccgc aagauggccg gcgagauggc ggaggggcuu     1140

agauacaucc cucggagcug uggaucuaau uccuauguuc uggugccggu cuga           1194


<210>  5128
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CX3CL1__Homo_sapiens__CAG33707

<400>  5128
auggcaccua uaagcuuaag cugguuacua agauuagcaa ccuucuguca ucuaacaguu       60

uuacuagcag gacaacauca uggaguaacu aaauguaaca uaacauguuc aaaaaugacu      120

aguaaaauac caguagcuuu auuaauacac uaucaacaaa aucaagcaag uuguggcaaa      180

agagcaauaa uccuagaaac aagacaacau agauuauucu gugcagaucc aaaagaacaa      240

uggguaaaag augcaaugca acauuuagau agacaagcag cagccuuaac uagaaaugga      300

gguacauuug aaaaacaaau aggagaagua aaaccaagga caacaccugc agcaggagga      360

auggaugaau caguaguuuu agaaccagaa gccacaggug aaucuucauc accagaacca      420

acaccauccu cacaagaagc acaaagagca uuaggaacau caccagaauu acccacagga      480

guuacaggga guagugguac aagguuaccu ccuacaccaa aagcccaaga ugguggaccc      540

guugguacag aacuuuuuag aguacccccu guaucaacag cagcaacaug gcaaucauca      600

gcaccacauc aaccaggacc aucauuaugg gcagaagcaa aaacaucaga agcaccuucu      660

acacaagacc caucaacaca agcuucaaca gcaucaucuc cagcucccga agaaaacgcu      720

ccuucagaag gacaaagagu auggggacaa ggacaaucac caagaccaga aaauucacuu      780

gaacgagaag aaaugggacc aguaccagca cacaccgaug cauuucaaga uuggggacca      840

ggaaguaugg cacauguaag uguaguacca guaaguucag aagguacacc aucaagagaa      900

ccagucgcau caggaagcug gacaccaaaa gcagaagaac caauacacgc gacaauggac      960

ccccaaagac uaggaguauu aauaacacca guccccgaug cccaagcagc uacaagaaga     1020

caagcuguag gccuucuagc uuuucuagga uuauuauuuu guuugggugu ugcaauguuu     1080

acauaucaau ccuuacaagg augcccacga aaaauggcag gagaaauggc agaaggacua     1140

agauauauac cccgaucaug cggaucaaau ucauacguac uuguaccagu auaa           1194


<210>  5129
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL10__Homo_sapiens__A0A024RDA4

<400>  5129

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  5130
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL10__Homo_sapiens__EAX05772

<400>  5130
augaaucaaa cugccauucu gauuugcugc cuuaucuuuc ugacucuaag uggcauucaa       60

ggaguaccuc ucucuagaac uguacgcugu accugcauca gcauuaguaa ucaaccuguu      120

aauccaaggu cuuuagaaaa acuugaaauu auuccugcaa gccaauuuug uccacguguu      180

gagaucauug cuacaaugaa aaagaagggu gagaagagau gucugaaucc agaaucgaag      240

gccaucaaga auuuacugaa agcaguuagc aaggaaaggu cuaaaagauc uccuuaa         297


<210>  5131
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5131
augaaccaga ccgccauccu gaucugcugc cucaucuucc ugacccugag cggcauccag       60

ggggugcccc ucucccgcac cguccggugc acgugcauca gcaucuccaa ccagccggug      120

aacccccgca gccuggagaa gcuggagauc auccccgccu cccaguucug cccccgggug      180

gagaucaucg cgaccaugaa gaagaagggc gagaagcgcu gccucaaccc ggagagcaag      240

gccaucaaga accugcugaa ggccgucucc aaggagcgga gcaagcgcuc ccccuga         297


<210>  5132
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5132
augaaccaga ccgccauccu caucugcugc cucaucuucc ucacccucuc cggcauccag       60

ggcguccccc ucucccgcac cguccgcugc accugcaucu ccaucuccaa ccagcccguc      120

aacccccgcu cccucgagaa gcucgagauc auccccgccu cccaguucug cccccgcguc      180

gagaucaucg ccaccaugaa gaagaagggc gagaagcgcu gccucaaccc cgaguccaag      240

gccaucaaga accuccucaa ggccgucucc aaggagcgcu ccaagcgcuc ccccuga         297


<210>  5133
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5133
augaaccaga ccgccauccu gauuugcugu cucauauucc uuacacugag cggcauccaa       60

ggggugcccu uguccagaac ugucaggugc acguguauuu cuaucucaaa ucagccuguu      120

aacccacgga guuuagagaa gcuggaaauu aucccggcua gccaguuuug cccccgcgug      180

gagauaaucg caaccaugaa aaagaaagga gaaaagcgau gucuaaaucc ugaguccaaa      240

gccauuaaga accuccugaa ggcgguaucu aaagaacguu cgaagagauc accauga         297


<210>  5134
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5134
augaaccaga ccgccauccu gaucugcugc cugaucuucc ugacccugag cggcauccag       60

ggcgugcccc ugagcagaac cgugagaugc accugcauca gcaucagcaa ccagcccgug      120

aaccccagaa gccuggagaa gcuggagauc auccccgcca gccaguucug ccccagagug      180

gagaucaucg ccaccaugaa gaagaagggc gagaagagau gccugaaccc cgagagcaag      240

gccaucaaga accugcugaa ggccgugagc aaggagagaa gcaagagaag ccccuga         297


<210>  5135
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5135
augaaccaga ccgccauccu gauuugcugu cucaucuucc ugacacuuag cggcauucaa       60

ggggugcccc uguccagaac gguccggugc accuguaucu cuauuagcaa ucagccuguu      120

aacccgcgcu cccucgagaa gcuggaaauc auccccgcuu cucaguuuug cccuagagug      180

gagauuaucg ccacaaugaa aaagaaagga gaaaagcggu gucuuaaucc cgagagcaaa      240

gcgauuaaga accugcucaa ggcugugucc aaagaacgcu cuaagagaag cccuuga         297


<210>  5136
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL10__Homo_sapiens__EAX05772

<400>  5136
augaaccaaa cagcaauacu aauaugcugc cuaauauucc uaacacuauc aggaauacaa       60

ggaguaccac uaucaagaac aguaagaugc acaugcauau caauaucaaa ccaaccagua      120

aacccaagau cacuagaaaa acuagaaaua auaccagcau cacaauucug cccaagagua      180

gaaauaauag caacaaugaa aaaaaaagga gaaaaaagau gccuaaaccc agaaucaaaa      240

gcaauaaaaa accuacuaaa agcaguauca aaagaaagau caaaaagauc accauaa         297


<210>  5137
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL10__Homo_sapiens__P02778

<400>  5137

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  5138
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL10__Homo_sapiens__AAH10954

<400>  5138
augaaucaaa cugccauucu gauuugcugc cuuaucuuuc ugacucuaag uggcauucaa       60

ggaguaccuc ucucuagaac uguacgcugu accugcauca gcauuaguaa ucaaccuguu      120

aauccaaggu cuuuagaaaa acuugaaauu auuccugcaa gccaauuuug uccacguguu      180

gagaucauug cuacaaugaa aaagaagggu gagaagagau gucugaaucc agaaucgaag      240

gccaucaaga auuuacugaa agcaguuagc aaggaaaggu cuaaaagauc uccuuaa         297


<210>  5139
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5139
augaaccaga ccgccauccu gaucugcugc cucaucuucc ugacccugag cggcauccag       60

ggggugcccc ucucccgcac cguccggugc acgugcauca gcaucuccaa ccagccggug      120

aacccccgca gccuggagaa gcuggagauc auccccgccu cccaguucug cccccgggug      180

gagaucaucg cgaccaugaa gaagaagggc gagaagcgcu gccucaaccc ggagagcaag      240

gccaucaaga accugcugaa ggccgucucc aaggagcgga gcaagcgcuc ccccuga         297


<210>  5140
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5140
augaaccaga ccgccauccu caucugcugc cucaucuucc ucacccucuc cggcauccag       60

ggcguccccc ucucccgcac cguccgcugc accugcaucu ccaucuccaa ccagcccguc      120

aacccccgcu cccucgagaa gcucgagauc auccccgccu cccaguucug cccccgcguc      180

gagaucaucg ccaccaugaa gaagaagggc gagaagcgcu gccucaaccc cgaguccaag      240

gccaucaaga accuccucaa ggccgucucc aaggagcgcu ccaagcgcuc ccccuga         297


<210>  5141
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5141
augaaccaga ccgccauccu gauuugcugu cucauauucc uuacacugag cggcauccaa       60

ggggugcccu uguccagaac ugucaggugc acguguauuu cuaucucaaa ucagccuguu      120

aacccacgga guuuagagaa gcuggaaauu aucccggcua gccaguuuug cccccgcgug      180

gagauaaucg caaccaugaa aaagaaagga gaaaagcgau gucuaaaucc ugaguccaaa      240

gccauuaaga accuccugaa ggcgguaucu aaagaacguu cgaagagauc accauga         297


<210>  5142
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5142
augaaccaga ccgccauccu gaucugcugc cugaucuucc ugacccugag cggcauccag       60

ggcgugcccc ugagcagaac cgugagaugc accugcauca gcaucagcaa ccagcccgug      120

aaccccagaa gccuggagaa gcuggagauc auccccgcca gccaguucug ccccagagug      180

gagaucaucg ccaccaugaa gaagaagggc gagaagagau gccugaaccc cgagagcaag      240

gccaucaaga accugcugaa ggccgugagc aaggagagaa gcaagagaag ccccuga         297


<210>  5143
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5143
augaaccaga ccgccauccu gauuugcugu cucaucuucc ugacacuuag cggcauucaa       60

ggggugcccc uguccagaac gguccggugc accuguaucu cuauuagcaa ucagccuguu      120

aacccgcgcu cccucgagaa gcuggaaauc auccccgcuu cucaguuuug cccuagagug      180

gagauuaucg ccacaaugaa aaagaaagga gaaaagcggu gucuuaaucc cgagagcaaa      240

gcgauuaaga accugcucaa ggcugugucc aaagaacgcu cuaagagaag cccuuga         297


<210>  5144
<211>  297
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL10__Homo_sapiens__AAH10954

<400>  5144
augaaccaaa cagcaauacu cauaugcugc cuaauauucc uaacacuauc aggaauacaa       60

ggaguaccac uaucaagaac aguaagaugc acaugcauau caauaucaaa ccaaccagua      120

aacccaagau cacuagaaaa acuagaaaua auaccagcau cacaauucug cccacgagua      180

gaaauaauag caacaaugaa aaaaaaagga gaaaaaagau gccuaaaccc agaaucaaaa      240

gcaauaaaaa accuacuaaa agcaguauca aaagaaagau caaaacgauc accauaa         297


<210>  5145
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL11__Homo_sapiens__O14625

<400>  5145

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  5146
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL11__Homo_sapiens__AAC39775

<400>  5146
augaguguga agggcauggc uauagccuug gcugugauau ugugugcuac aguuguucaa       60

ggcuucccca uguucaaaag aggacgcugu cuuugcauag gcccuggggu aaaagcagug      120

aaaguggcag auauugagaa agccuccaua auguacccaa guaacaacug ugacaaaaua      180

gaagugauua uuacccugaa agaaaauaaa ggacaacgau gccuaaaucc caaaucgaag      240

caagcaaggc uuauaaucaa aaaaguugaa agaaagaauu uuuaa                      285


<210>  5147
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5147
augagcguga agggcauggc caucgcccug gcggucaucc ucugcgccac cguggugcag       60

ggguucccca uguucaagcg cggccggugc cugugcaucg ggccgggcgu caaggccgug      120

aagguggccg acaucgagaa ggccuccauc auguacccca gcaacaacug cgacaagauc      180

gaggucauca ucacccugaa ggagaacaag gggcagcgcu gccucaaccc caaguccaag      240

caggcgcggc ugaucaucaa gaagguggag cgcaagaacu ucuga                      285


<210>  5148
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5148
auguccguca agggcauggc caucgcccuc gccgucaucc ucugcgccac cgucguccag       60

ggcuucccca uguucaagcg cggccgcugc cucugcaucg gccccggcgu caaggccguc      120

aaggucgccg acaucgagaa ggccuccauc auguaccccu ccaacaacug cgacaagauc      180

gaggucauca ucacccucaa ggagaacaag ggccagcgcu gccucaaccc caaguccaag      240

caggcccgcc ucaucaucaa gaaggucgag cgcaagaacu ucuga                      285


<210>  5149
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5149
augagcguga aaggcauggc caucgcucug gcagucauuc ucugcgccac cguugugcag       60

ggguucccca uguuuaaaag aggaaggugu cuuugcauag guccuggcgu aaaggcggug      120

aaagucgcug acaucgagaa ggccuccauu auguacccau cuaacaauug ugauaaaauc      180

gaagugauua ucacacugaa ggagaacaag gggcaacggu gcuugaaucc gaaaucaaag      240

caggcacgcu uaauaaucaa aaagguugaa cgaaagaacu ucuga                      285


<210>  5150
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5150
augagcguga agggcauggc caucgcccug gccgugaucc ugugcgccac cguggugcag       60

ggcuucccca uguucaagag aggcagaugc cugugcaucg gccccggcgu gaaggccgug      120

aagguggccg acaucgagaa ggccagcauc auguacccca gcaacaacug cgacaagauc      180

gaggugauca ucacccugaa ggagaacaag ggccagagau gccugaaccc caagagcaag      240

caggccagac ugaucaucaa gaagguggag agaaagaacu ucuga                      285


<210>  5151
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5151
augagcguga agggcauggc caucgcucug gccgucauuc ucugcgcgac cguugugcag       60

ggguucccca uguuuaaaag aggacggugu cugugcaucg gcccuggggu gaaggcuguc      120

aaaguggccg acauugagaa ggccuccauc auguacccgu cuaacaauug ugauaaaauu      180

gaaguuauca ucacacuuaa ggagaacaag ggacaacgcu gccugaaucc caaaagcaag      240

caggcuagac ucauuaucaa aaagguggaa cggaaaaacu ucuga                      285


<210>  5152
<211>  285
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL11__Homo_sapiens__AAC39775

<400>  5152
augucaguaa aaggaauggc aauagcacua gcaguaauac uaugcgcaac aguaguacaa       60

ggauucccaa uguucaaaag aggaagaugc cuaugcauag gaccaggagu aaaagcagua      120

aaaguagcag acauagaaaa agcaagcaua auguauccau caaacaauug cgacaaaaua      180

gaaguaauaa uaacauuaaa agaaaacaaa ggacaaagau gccuaaaucc aaaaagcaaa      240

caagcaagac uaauaauaaa aaaaguagaa agaaaaaacu uuuaa                      285


<210>  5153
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL12__Homo_sapiens__P48061

<400>  5153

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  5154
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL12__Homo_sapiens__AAA97434

<400>  5154
augaacgcca aggucguggu cgugcugguc cucgugcuga ccgcgcucug ccucagcgac       60

gggaagcccg ucagccugag cuacagaugc ccaugccgau ucuucgaaag ccauguugcc      120

agagccaacg ucaagcaucu caaaauucuc aacacuccaa acugugcccu ucagauugua      180

gcccggcuga agaacaacaa cagacaagug ugcauugacc cgaagcuaaa guggauucag      240

gaguaccugg agaaagcuuu aaacaagagg uucaagaugu ga                         282


<210>  5155
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5155
augaacgcca agguggucgu ggugcugguc cucgugcuga ccgcccugug ccucagcgac       60

ggcaagcccg ugucccugag cuaccgcugc ccgugccggu ucuucgaguc ccacgucgcg      120

cgcgccaacg ugaagcaccu gaagauccuc aacaccccca acugcgcccu gcagaucgug      180

gcccggcuga agaacaacaa ccgccagguc ugcaucgacc ccaagcucaa guggauccag      240

gaguaccugg agaaggcccu gaacaagcgg uucaagaugu ga                         282


<210>  5156
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5156
augaacgcca aggucgucgu cguccucguc cucguccuca ccgcccucug ccucuccgac       60

ggcaagcccg ucucccucuc cuaccgcugc cccugccgcu ucuucgaguc ccacgucgcc      120

cgcgccaacg ucaagcaccu caagauccuc aacaccccca acugcgcccu ccagaucguc      180

gcccgccuca agaacaacaa ccgccagguc ugcaucgacc ccaagcucaa guggauccag      240

gaguaccucg agaaggcccu caacaagcgc uucaagaugu ga                         282


<210>  5157
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5157
augaacgcca agguggucgu ugugcuggua cucgugcuua ccgcucugug cuugagcgac       60

ggcaaacccg ucuccuuauc uuacagaugu ccuugcaggu ucuuugaguc acacguggca      120

cgggccaaug uuaagcaucu gaaaauccua aacacaccaa auugugcgcu ccagauugug      180

gcucgccuga agaacaauaa ccgacaaguc ugcauagauc cgaaacuuaa guggauccag      240

gaauaucugg agaaggccuu gaauaaacgu uucaagaugu ga                         282


<210>  5158
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5158
augaacgcca aggugguggu ggugcuggug cuggugcuga ccgcccugug ccugagcgac       60

ggcaagcccg ugagccugag cuacagaugc cccugcagau ucuucgagag ccacguggcc      120

agagccaacg ugaagcaccu gaagauccug aacaccccca acugcgcccu gcagaucgug      180

gccagacuga agaacaacaa cagacaggug ugcaucgacc ccaagcugaa guggauccag      240

gaguaccugg agaaggcccu gaacaagaga uucaagaugu ga                         282


<210>  5159
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5159
augaacgcca agguggucgu ugugcuggug cucguccuga ccgcucuuug ccugagcgac       60

ggcaaacccg ugucccucuc uuacagaugu ccuugccggu ucuuugagag ccacguugcc      120

cgcgcgaaug ugaagcaucu gaaaauccuu aacacaccga auugugcucu gcagauuguc      180

gccagacuca agaacaauaa ccggcaagug ugcaucgauc ccaaacugaa guggauucag      240

gaauaucugg agaaggcccu caauaaacgc uucaagaugu ga                         282


<210>  5160
<211>  282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL12__Homo_sapiens__AAA97434

<400>  5160
augaacgcaa aaguaguagu aguacuagua cuaguacuaa cagcacuaug cuuaagcgac       60

ggaaaaccag uaagccuaag cuacagaugc ccaugcagau ucuucgaaag ccacguagca      120

agagcaaacg uaaaacaccu aaaaauacua aacacaccaa acugcgcacu acaaauagua      180

gcaagacuaa aaaacaacaa cagacaagua ugcauagacc caaaacuaaa auggauacaa      240

gaauaccuag aaaaagcacu aaacaaaaga uucaaaaugu aa                         282


<210>  5161
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL13__Homo_sapiens__L8E878

<400>  5161

Met Tyr Thr Cys Ile Leu Ser His Ile Cys Leu Asp Lys Leu Leu Ser 
1               5                   10                  15      


Leu Thr Ser Phe Ser Leu Thr Phe Phe Val Gly Gly Gly Ala Gly Gly 
            20                  25                  30          


Thr Leu Val Ser Asn Ser Leu Met Ile Pro Ile Asn Leu Met Thr Phe 
        35                  40                  45              


Asn Lys Val Glu Gln Thr Phe Tyr Leu Lys Lys Lys Lys Lys 
    50                  55                  60          


<210>  5162
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL13__Homo_sapiens__CCQ42936

<400>  5162
auguacacau guauccuuuc acacauuugc cuugacaaac uucuuucacu cacaucuuuu       60

ucacugacuu uuuuuguggg gggcggggcc ggggggacuc ugguaucuaa uucuuuaaug      120

auuccuauaa aucuaaugac auucaauaaa guugagcaaa cauuuuacuu aaaaaaaaaa      180

aaaaaauaa                                                              189


<210>  5163
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5163
auguacacgu gcauccugag ccacaucugc cucgacaagc ugcugucccu caccagcuuc       60

ucccugaccu ucuucguggg cgggggcgcc gggggcaccc uggucagcaa cucccucaug      120

auccccauca accugaugac cuucaacaag guggagcaga ccuucuaccu gaagaagaag      180

aagaaguga                                                              189


<210>  5164
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5164
auguacaccu gcauccucuc ccacaucugc cucgacaagc uccucucccu caccuccuuc       60

ucccucaccu ucuucgucgg cggcggcgcc ggcggcaccc ucgucuccaa cucccucaug      120

auccccauca accucaugac cuucaacaag gucgagcaga ccuucuaccu caagaagaag      180

aagaaguga                                                              189


<210>  5165
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5165
auguacacuu gcauccugag ccacauuugu cucgacaaac uucuguccuu gacaucuuuc       60

ucauuaaccu uuuucguggg cgggggagcc gguggcacgc uggucaguaa cagccuaaug      120

auacccauca aucucaugac cuuuaacaag guugagcaga cauucuaucu gaagaaaaag      180

aaaaaguga                                                              189


<210>  5166
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5166
auguacaccu gcauccugag ccacaucugc cuggacaagc ugcugagccu gaccagcuuc       60

agccugaccu ucuucguggg cggcggcgcc ggcggcaccc uggugagcaa cagccugaug      120

auccccauca accugaugac cuucaacaag guggagcaga ccuucuaccu gaagaagaag      180

aagaaguga                                                              189


<210>  5167
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5167
auguauaccu gcauccugag ccacauuugu cucgacaagc ugcuuucccu gacaucuuuc       60

agccucacgu uuuucguggg cgggggagcc ggcgggaccc uggucuccaa cucucuuaug      120

auccccauua aucugaugac auuuaacaaa guugagcaga ccuucuaccu caagaaaaag      180

aaaaaguga                                                              189


<210>  5168
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL13__Homo_sapiens__CCQ42936

<400>  5168
auguacacau gcauacuauc acacauaugc cuagacaaac uacuaucacu aacaucauuc       60

ucacuaacau ucuucguagg aggaggagca ggaggaacac uaguaucaaa cucacuaaug      120

auaccaauaa accuaaugac auucaacaaa guagaacaaa cauucuaccu aaaaaaaaaa      180

aaaaaauaa                                                              189


<210>  5169
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL13__Homo_sapiens__O43927

<400>  5169

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  5170
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL13__Homo_sapiens__AAC14402

<400>  5170
augaaguuca ucucgacauc ucugcuucuc augcugcugg ucagcagccu cucuccaguc       60

caagguguuc uggaggucua uuacacaagc uugaggugua gaugugucca agagagcuca      120

gucuuuaucc cuagacgcuu cauugaucga auucaaaucu ugccccgugg gaaugguugu      180

ccaagaaaag aaaucauagu cuggaagaag aacaagucaa uugugugugu ggacccucaa      240

gcugaaugga uacaaagaau gauggaagua uugagaaaaa gaaguucuuc aacucuacca      300

guuccagugu uuaagagaaa gauucccuga                                       330


<210>  5171
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5171
augaaguuca ucagcaccuc ccugcuccug augcugcucg ugagcucccu gagccccguc       60

cagggcgugc uggaggugua cuacaccucc cuccgcugcc ggugcgucca ggagagcucc      120

guguucaucc cgcgccgguu caucgaccgc auccagaucc ugccccgggg gaacggcugc      180

ccccgcaagg agaucaucgu guggaagaag aacaagagca ucgucugcgu ggacccccag      240

gccgagugga uccagcggau gauggaggug cugcgcaagc gguccagcuc cacgcucccg      300

guccccgugu ucaagcgcaa gauccccuga                                       330


<210>  5172
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5172
augaaguuca ucuccaccuc ccuccuccuc augcuccucg ucuccucccu cucccccguc       60

cagggcgucc ucgaggucua cuacaccucc cuccgcugcc gcugcgucca ggaguccucc      120

gucuucaucc cccgccgcuu caucgaccgc auccagaucc ucccccgcgg caacggcugc      180

ccccgcaagg agaucaucgu cuggaagaag aacaagucca ucgucugcgu cgacccccag      240

gccgagugga uccagcgcau gauggagguc cuccgcaagc gcuccuccuc cacccucccc      300

guccccgucu ucaagcgcaa gauccccuga                                       330


<210>  5173
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5173
augaaguuca ucagcaccuc ccugcuccuu augcuguugg ugucuucauu aagucccguc       60

cagggcguuc uggaggugua cuauacaagc cuaagaugua ggugcguaca agaauccucu      120

guguuuauuc cucggcgcuu cauagaccga auccagauuc ucccacgugg gaacggaugc      180

ccgagaaaag agaucauugu cuggaagaaa aauaagucga ucgugugugu ugauccccag      240

gccgaaugga uacagaggau gauggaggug cugcggaaac gcucaagcag uacucuuccu      300

gucccagugu uuaagagaaa gauccccuga                                       330


<210>  5174
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5174
augaaguuca ucagcaccag ccugcugcug augcugcugg ugagcagccu gagccccgug       60

cagggcgugc uggaggugua cuacaccagc cugagaugca gaugcgugca ggagagcagc      120

guguucaucc ccagaagauu caucgacaga auccagaucc ugcccagagg caacggcugc      180

cccagaaagg agaucaucgu guggaagaag aacaagagca ucgugugcgu ggacccccag      240

gccgagugga uccagagaau gauggaggug cugagaaaga gaagcagcag cacccugccc      300

gugcccgugu ucaagagaaa gauccccuga                                       330


<210>  5175
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5175
augaaguuca ucagcaccuc ccugcuccug augcuucugg ugucuagccu cucccccguc       60

cagggcguuc uggaggugua cuauacaucu cuuagaugcc ggugugugca agaaagcucc      120

gucuuuauuc cucgcagauu caucgaccgg auucagaucc ugccgcgcgg gaacggaugc      180

cccagaaaag agauuaucgu guggaagaaa aauaagucua ucguuugugu ggauccucag      240

gccgaaugga uucagcggau gauggagguc cuccgcaaaa gaagcuccag cacgcugccc      300

gugccuguuu uuaagcggaa gauccccuga                                       330


<210>  5176
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL13__Homo_sapiens__AAC14402

<400>  5176
augaaauuua uaucaacauc acuacuacua augcuauuag uaucaagccu aagcccagua       60

caaggaguac ucgaaguaua uuacacaagc uuaagaugua gauguguaca agaaucaagc      120

guauucauac caagaagauu uauagacaga auacaaauac uaccaagagg aaacggaugc      180

ccaagaaaag aaauaauagu auggaaaaaa aauaaaucaa uaguaugcgu agacccacaa      240

gcagaaugga uacaaagaau gauggaagua uuaagaaaaa gaucaagcuc aacauuacca      300

guaccaguau ucaaaagaaa aauaccauaa                                       330


<210>  5177
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL14__Homo_sapiens__O95715

<400>  5177

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  5178
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL14__Homo_sapiens__AAP35743

<400>  5178
augucccugc ucccacgccg cgccccuccg gucagcauga ggcuccuggc ggccgcgcug       60

cuccugcugc ugcuggcgcu guacaccgcg cguguggacg gguccaaaug caagugcucc      120

cggaagggac ccaagauccg cuacagcgac gugaagaagc uggaaaugaa gccaaaguac      180

ccgcacugcg aggagaagau gguuaucauc accaccaaga gcguguccag guaccgaggu      240

caggagcacu gccugcaccc caagcugcag agcaccaagc gcuucaucaa gugguacaac      300

gccuggaacg agaagcgcag ggucuacgaa gaauag                                336


<210>  5179
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5179
augagccugc ucccccgccg ggccccgccc guguccaugc gccugcuggc cgcggcccuc       60

cugcugcucc ugcuggcccu cuacaccgcc cgggucgacg gcagcaagug caagugcucc      120

cgcaaggggc ccaagauccg guacagcgac gugaagaagc uggagaugaa gcccaaguac      180

ccgcacugcg aggagaagau ggugaucauc accacgaagu ccgucagccg cuaccggggc      240

caggagcacu gccugcaccc caagcuccag uccaccaagc gcuucaucaa gugguacaac      300

gccuggaacg agaagcggcg cguguacgag gaguga                                336


<210>  5180
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5180
augucccucc ucccccgccg cgcccccccc gucuccaugc gccuccucgc cgccgcccuc       60

cuccuccucc uccucgcccu cuacaccgcc cgcgucgacg gcuccaagug caagugcucc      120

cgcaagggcc ccaagauccg cuacuccgac gucaagaagc ucgagaugaa gcccaaguac      180

ccccacugcg aggagaagau ggucaucauc accaccaagu ccgucucccg cuaccgcggc      240

caggagcacu gccuccaccc caagcuccag uccaccaagc gcuucaucaa gugguacaac      300

gccuggaacg agaagcgccg cgucuacgag gaguga                                336


<210>  5181
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5181
augagccugc uccccagaag ggccccucca guguccaugc ggcuucuggc ugcagccuug       60

uuacugcuac uccuggcgcu uuacaccgcu cgcgucgacg gcucuaagug caaauguuca      120

cgaaaggggc cgaaaauccg uuauagugau guuaagaaac uggagaugaa gcccaaguac      180

ccucacugcg aagagaaaau ggugauuaua acaacuaaga gcguauccag auauagggga      240

caggaacauu guuugcaccc aaaacuccaa ucuacgaagc gguucaucaa augguacaac      300

gccuggaaug agaagcgcag aguguaugaa gaguga                                336


<210>  5182
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5182
augagccugc ugcccagaag agcccccccc gugagcauga gacugcuggc cgccgcccug       60

cugcugcugc ugcuggcccu guacaccgcc agaguggacg gcagcaagug caagugcagc      120

agaaagggcc ccaagaucag auacagcgac gugaagaagc uggagaugaa gcccaaguac      180

ccccacugcg aggagaagau ggugaucauc accaccaaga gcgugagcag auacagaggc      240

caggagcacu gccugcaccc caagcugcag agcaccaaga gauucaucaa gugguacaac      300

gccuggaacg agaagagaag aguguacgag gaguga                                336


<210>  5183
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5183
augagccugc uccccagacg ggccccuccg guguccaugc gccugcuugc ugccgcgcug       60

cuccugcuuc ugcucgcucu guacaccgcc agagucgacg gcucuaagug caaauguagc      120

cggaaggggc ccaaaauccg cuauuccgau guuaagaaac uggagaugaa gccuaaguac      180

ccccacugcg aagagaaaau ggugauuauc acaacgaagu cugugagcag auaucgggga      240

caggaacauu gucuccaccc uaaacugcaa uccaccaagc gcuucauuaa augguacaac      300

gccuggaaug agaagagacg ggucuaugaa gaguga                                336


<210>  5184
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL14__Homo_sapiens__AAP35743

<400>  5184
augucacuac uaccaagaag agcaccacca guaucaauga gacuacuagc agcagcacua       60

cuacuacuau uacuagcacu auacacagca agaguagacg gaagcaaaug caaaugcuca      120

agaaaaggac caaaaauaag auacucagac guaaaaaaau uagaaaugaa accaaaauac      180

ccacacugcg aagaaaaaau gguaauaaua acaacaaaau caguaucaag auacagagga      240

caagaacacu gccuacaccc aaaacuacaa agcacaaaaa gauucauaaa augguacaac      300

gcauggaacg aaaaaagaag aguauacgaa gaauaa                                336


<210>  5185
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL15__Mus_musculus__Q9WVL7

<400>  5185

Met Ala Ala Gln Gly Trp Ser Met Leu Leu Leu Ala Val Leu Asn Leu 
1               5                   10                  15      


Gly Ile Phe Val Arg Pro Cys Asp Thr Gln Glu Leu Arg Cys Leu Cys 
            20                  25                  30          


Ile Gln Glu His Ser Glu Phe Ile Pro Leu Lys Leu Ile Lys Asn Ile 
        35                  40                  45              


Met Val Ile Phe Glu Thr Ile Tyr Cys Asn Arg Lys Glu Val Ile Ala 
    50                  55                  60                  


Val Pro Lys Asn Gly Ser Met Ile Cys Leu Asp Pro Asp Ala Pro Trp 
65                  70                  75                  80  


Val Lys Ala Thr Val Gly Pro Ile Thr Asn Arg Phe Leu Pro Glu Asp 
                85                  90                  95      


Leu Lys Gln Lys Glu Phe Pro Pro Ala Met Lys Leu Leu Tyr Ser Val 
            100                 105                 110         


Glu His Glu Lys Pro Leu Tyr Leu Ser Phe Gly Arg Pro Glu Asn Lys 
        115                 120                 125             


Arg Ile Phe Pro Phe Pro Ile Arg Glu Thr Ser Arg His Phe Ala Asp 
    130                 135                 140                 


Leu Ala His Asn Ser Asp Arg Asn Phe Leu Arg Asp Ser Ser Glu Val 
145                 150                 155                 160 


Ser Leu Thr Gly Ser Asp Ala 
                165         


<210>  5186
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL15__Mus_musculus__AAD38079

<400>  5186
auggcugcuc aaggcugguc caugcuccug cuggcugucc uuaaccuagg caucuucguc       60

cgucccugug acacucaaga gcuacgaugu cuguguauuc aggaacacuc ugaauucauu      120

ccucucaaac ucauuaaaaa uauaauggug auauucgaga ccauuuacug caacagaaag      180

gaagugauag cagucccaaa aaaugggagu augauuuguu uggauccuga ugcuccaugg      240

gugaaggcua cuguuggccc aauuacuaac agguuccuac cugaggaccu caaacaaaag      300

gaauuuccac cggcaaugaa gcuucuguau aguguugagc augaaaagcc ucuauaucuu      360

ucauuuggga gaccugagaa caagagaaua uuucccuuuc caauucggga gaccucuaga      420

cacuuugcug auuuagcuca caacagugau aggaauuuuc uacgggacuc cagugaaguc      480

agcuugacag gcagugaugc cuaa                                             504


<210>  5187
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL15__Mus_musculus__AAD38079

<400>  5187
auggccgccc agggcuggag caugcugcuc cuggcggugc ugaaccucgg gaucuucguc       60

cgccccugcg acacccagga gcugcggugc cugugcaucc aggagcacuc cgaguucauc      120

ccgcucaagc ugaucaagaa caucauggug aucuucgaga ccaucuacug caaccgcaag      180

gaggugaucg ccguccccaa gaacggcagc augaucugcc uggaccccga cgcccccugg      240

gugaaggcca cgguggggcc gaucaccaac cgguuccucc ccgaggaccu gaagcagaag      300

gaguucccgc ccgccaugaa gcugcucuac uccgucgagc acgagaagcc ccuguaccug      360

agcuucggcc gccccgagaa caagcggauc uuccccuucc ccauccgcga gaccucccgg      420

cacuucgcgg accucgccca caacagcgac cgcaacuucc ugcgggacuc cagcgaggug      480

ucccugaccg ggagcgacgc cuga                                             504


<210>  5188
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL15__Mus_musculus__AAD38079

<400>  5188
auggccgccc agggcugguc caugcuccuc cucgccgucc ucaaccucgg caucuucguc       60

cgccccugcg acacccagga gcuccgcugc cucugcaucc aggagcacuc cgaguucauc      120

ccccucaagc ucaucaagaa caucaugguc aucuucgaga ccaucuacug caaccgcaag      180

gaggucaucg ccguccccaa gaacggcucc augaucugcc ucgaccccga cgcccccugg      240

gucaaggcca ccgucggccc caucaccaac cgcuuccucc ccgaggaccu caagcagaag      300

gaguuccccc ccgccaugaa gcuccucuac uccgucgagc acgagaagcc ccucuaccuc      360

uccuucggcc gccccgagaa caagcgcauc uuccccuucc ccauccgcga gaccucccgc      420

cacuucgccg accucgccca caacuccgac cgcaacuucc uccgcgacuc cuccgagguc      480

ucccucaccg gcuccgacgc cuga                                             504


<210>  5189
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL15__Mus_musculus__AAD38079

<400>  5189
auggccgcuc agggcuggag caugcugcuc cuugcagugc ugaacuuggg gaucuucguc       60

agacccugcg acacccaaga guuaaggugu cugugcauuc aggaacacuc cgaguuuaua      120

ccucuaaagc ucaucaaaaa uauuaugguu aucuucgaaa caauuuacug uaaccggaag      180

gaggugaucg ccguaccgaa aaauggaucu augauaugcc uggauccaga cgcgcccugg      240

gugaaggcua cugucggucc uaucacgaac cgcuuucuuc cagaagaucu gaaacagaag      300

gaguuucccc cugccaugaa guugcucuau ucaguggagc augaaaaacc acuguaccug      360

aguuuuggcc gacccgagaa uaagcguauu uucccuuuuc caaucagaga aaccagcagg      420

cacuucgcag accucgccca uaacuccgau cggaauuucu uacgcgacuc uucggagguu      480

ucacugacag ggagcgaugc uuga                                             504


<210>  5190
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL15__Mus_musculus__AAD38079

<400>  5190
auggccgccc agggcuggag caugcugcug cuggccgugc ugaaccuggg caucuucgug       60

agacccugcg acacccagga gcugagaugc cugugcaucc aggagcacag cgaguucauc      120

ccccugaagc ugaucaagaa caucauggug aucuucgaga ccaucuacug caacagaaag      180

gaggugaucg ccgugcccaa gaacggcagc augaucugcc uggaccccga cgcccccugg      240

gugaaggcca ccgugggccc caucaccaac agauuccugc ccgaggaccu gaagcagaag      300

gaguuccccc ccgccaugaa gcugcuguac agcguggagc acgagaagcc ccuguaccug      360

agcuucggca gacccgagaa caagagaauc uuccccuucc ccaucagaga gaccagcaga      420

cacuucgccg accuggccca caacagcgac agaaacuucc ugagagacag cagcgaggug      480

agccugaccg gcagcgacgc cuga                                             504


<210>  5191
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL15__Mus_musculus__AAD38079

<400>  5191
auggccgcuc agggcuggag caugcugcuc cuggccgugc uuaaccuggg gaucuucguc       60

agacccugcg acacccaaga gcuccggugu cugugcauuc aggaacacuc cgaguuuauc      120

ccucuuaagc ugauuaaaaa uaucaugguu auuuucgaaa caaucuacug uaaccgcaag      180

gaggugaucg cggugccgaa aaauggaucu augauuugcc ucgaucccga cgcuccuugg      240

gucaaggcca cggugggccc caucaccaac agauuucugc cugaagaucu gaaacagaag      300

gaguuucccc cugccaugaa gcuccuguau agcguugagc augaaaaacc gcuuuaccug      360

uccuucgggc ggcccgagaa uaagcgcauu uucccuuuuc ccaucagaga aacaucucgg      420

cacuucgcug accucgccca uaacagcgau cgcaauuuuc ugagagacuc cucugaggug      480

agccuuaccg gauccgaugc uuga                                             504


<210>  5192
<211>  504
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL15__Mus_musculus__AAD38079

<400>  5192
auggcagcac aaggaugguc aaugcuacua cuagcaguac uaaaccuagg aauauucgua       60

agacccugcg acacacaaga acuaagaugc cuaugcauac aagaacacuc agaauucaua      120

ccacuaaaac uaauaaaaaa caucauggua auauucgaaa caauauacug caacagaaaa      180

gaaguaauag caguaccaaa aaacggcuca augauaugcc uagaccccga cgcaccaugg      240

guaaaagcaa cagucggacc aauaacaaac agauuccuac cagaagaccu aaaacaaaaa      300

gaauucccac cagcaaugaa acuacuauac ucaguagaac acgaaaaacc auuauaucua      360

ucauucggaa gaccagaaaa caaaagaaua uucccauucc caauaagaga aacauccaga      420

cacuucgcag accuagcaca caacucagau agaaacuucc uaagagacuc aucagaagua      480

ucacuaacag gaucagacgc auaa                                             504


<210>  5193
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL1__Homo_sapiens__P09341

<400>  5193

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  5194
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL1__Homo_sapiens__AAA35933

<400>  5194
auggcccgcg cugcucucuc cgccgccccc agcaaucccc ggcuccugcg aguggcacug       60

cugcuccugc uccugguagc cgcuggccgg cgcgcagcag gagcguccgu ggccacugaa      120

cugcgcugcc agugcuugca gacccugcag ggaauucacc ccaagaacau ccaaagugug      180

aacgugaagu cccccggacc ccacugcgcc caaaccgaag ucauagccac acucaagaau      240

gggcggaaag cuugccucaa uccugcaucc cccauaguua agaaaaucau cgaaaagaug      300

cugaacagug acaaauccaa cuga                                             324


<210>  5195
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5195
auggcccgcg ccgcgcugag cgccgccccc uccaacccgc ggcuccugcg cguggcccug       60

cuccugcugc uccuggucgc cgcgggccgg cgcgccgccg gggccagcgu ggcgaccgag      120

cugcggugcc agugccucca gacccugcag ggcauccacc ccaagaacau ccaguccgug      180

aacgucaaga gccccgggcc ccacugcgcc cagacggagg ugaucgccac ccugaagaac      240

ggccgcaagg ccugccucaa cccggccucc cccaucguga agaagaucau cgagaagaug      300

cugaacagcg acaaguccaa cuga                                             324


<210>  5196
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5196
auggcccgcg ccgcccucuc cgccgccccc uccaaccccc gccuccuccg cgucgcccuc       60

cuccuccucc uccucgucgc cgccggccgc cgcgccgccg gcgccuccgu cgccaccgag      120

cuccgcugcc agugccucca gacccuccag ggcauccacc ccaagaacau ccaguccguc      180

aacgucaagu cccccggccc ccacugcgcc cagaccgagg ucaucgccac ccucaagaac      240

ggccgcaagg ccugccucaa ccccgccucc cccaucguca agaagaucau cgagaagaug      300

cucaacuccg acaaguccaa cuga                                             324


<210>  5197
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5197
auggccagag cugcacugag cgccgcgccc uccaacccua ggcugcuucg gguggcucug       60

uuguuacugc uacucgucgc cgcaggccgc cgagccgcug gggcaucugu ugccaccgag      120

cugcguugcc agugucuuca aacacugcag ggaauccacc caaagaauau ucagucagug      180

aacguaaaaa guccgggucc ccauugcgcu cagacugaag ugauagccac guugaagaau      240

ggcagaaaag cgugucucaa cccugcaagc ccaaucguca agaaaauuau cgagaagaug      300

cucaauuccg acaagucuaa cuga                                             324


<210>  5198
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5198
auggccagag ccgcccugag cgccgccccc agcaacccca gacugcugag aguggcccug       60

cugcugcugc ugcugguggc cgccggcaga agagccgccg gcgccagcgu ggccaccgag      120

cugagaugcc agugccugca gacccugcag ggcauccacc ccaagaacau ccagagcgug      180

aacgugaaga gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

ggcagaaagg ccugccugaa ccccgccagc cccaucguga agaagaucau cgagaagaug      300

cugaacagcg acaagagcaa cuga                                             324


<210>  5199
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5199
auggccagag cugcccugag cgcggcuccc uccaacccuc ggcuccugcg cguggcccuu       60

cugcuccugc uucuggucgc cgcuggcaga cgggccgcug gggccucugu ugcgaccgag      120

cuccgcugcc agugucugca aacacugcag ggaauccacc cgaagaauau ucagagcgug      180

aacgugaaau cccccggccc ucauugcgcc cagacggaag ucaucgcuac ccucaagaau      240

gggagaaaag ccugucugaa ccccgcuucu ccuauuguga agaaaaucau ugagaagaug      300

cuuaauagcg acaaguccaa cuga                                             324


<210>  5200
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL1__Homo_sapiens__AAA35933

<400>  5200
auggcaagag cagcacuaag cgcagcacca agcaacccaa gacuacuaag aguagcacua       60

cuauuacuac uacuaguagc agcaggaaga agagcagcag gagcaucagu agcaacagaa      120

cuaagaugcc aaugccuaca aacacuacaa ggaauacacc caaaaaacau acaaagcgua      180

aacguaaaau caccaggacc acacugcgca caaacagaag uaauagcaac acuaaaaaac      240

ggaagaaaag caugccuaaa cccagcauca ccaauaguaa aaaaaauaau agaaaaaaug      300

cuaaacagcg acaaaucaaa cuaa                                             324


<210>  5201
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL2__Homo_sapiens__A0A024RDD9

<400>  5201

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  5202
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL2__Homo_sapiens__EAX05701

<400>  5202
auggcccgcg ccacgcucuc cgccgccccc agcaaucccc ggcuccugcg gguggcgcug       60

cugcuccugc uccugguggc cgccagccgg cgcgcagcag gagcgccccu ggccacugaa      120

cugcgcugcc agugcuugca gacccugcag ggaauucacc ucaagaacau ccaaagugug      180

aaggugaagu cccccggacc ccacugcgcc caaaccgaag ucauagccac acucaagaau      240

gggcagaaag cuugucucaa ccccgcaucg cccaugguua agaaaaucau cgaaaagaug      300

cugaaaaaug gcaaauccaa cuga                                             324


<210>  5203
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5203
auggcccgcg ccacccugag cgcggccccc uccaacccgc ggcuccugcg cguggcccug       60

cuccugcugc uccuggucgc cgccagccgg cgcgcggccg gcgcgccccu ggccaccgag      120

cuccggugcc agugccugca gacgcugcag gggauccacc ucaagaacau ccaguccgug      180

aaggucaaga gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

gggcagaagg ccugccugaa cccggccucc cccaugguga agaagaucau cgagaagaug      300

cucaagaacg gcaagagcaa cuga                                             324


<210>  5204
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5204
auggcccgcg ccacccucuc cgccgccccc uccaaccccc gccuccuccg cgucgcccuc       60

cuccuccucc uccucgucgc cgccucccgc cgcgccgccg gcgccccccu cgccaccgag      120

cuccgcugcc agugccucca gacccuccag ggcauccacc ucaagaacau ccaguccguc      180

aaggucaagu cccccggccc ccacugcgcc cagaccgagg ucaucgccac ccucaagaac      240

ggccagaagg ccugccucaa ccccgccucc cccaugguca agaagaucau cgagaagaug      300

cucaagaacg gcaaguccaa cuga                                             324


<210>  5205
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5205
auggccagag cuacccugag cgcagccccc uccaacccua ggcuccuucg gguggcgcug       60

uuguuacugc uacucgucgc ugccucucgc cgagcagccg gcgcuccacu ggcaacagag      120

cuucguugcc agugucugca aacuuugcag gggauccacc ucaagaauau ucagucaguu      180

aaagugaaga guccgggacc ccauugcgcc cagacggaag uaauagcuac ccugaaaaac      240

ggucaaaagg ccugucugaa uccugcgagc ccaaugguga aaaagaucau ugagaagaug      300

cucaaaaacg gcaaguccaa uuga                                             324


<210>  5206
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5206
auggccagag ccacccugag cgccgccccc agcaacccca gacugcugag aguggcccug       60

cugcugcugc ugcugguggc cgccagcaga agagccgccg gcgccccccu ggccaccgag      120

cugagaugcc agugccugca gacccugcag ggcauccacc ugaagaacau ccagagcgug      180

aaggugaaga gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

ggccagaagg ccugccugaa ccccgccagc cccaugguga agaagaucau cgagaagaug      300

cugaagaacg gcaagagcaa cuga                                             324


<210>  5207
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5207
auggccagag cuacccugag cgccgcgccc uccaacccuc ggcuccugcg cguggcccuu       60

cugcuccugc uucuggucgc ugccucuaga cgggcugccg gggcuccgcu cgccacagag      120

cugcgcugcc agugucugca aacgcuccag gggauccacc ugaagaauau ucagagcguu      180

aaagugaagu cccccggacc ucauugcgcg cagaccgaag ugaucgccac acuuaaaaac      240

ggccaaaagg cuugucugaa ucccgccucu ccuaugguca aaaagauuau cgagaagaug      300

cucaaaaacg gcaagagcaa uuga                                             324


<210>  5208
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL2__Homo_sapiens__EAX05701

<400>  5208
auggcaagag caacacuaag cgcagcacca agcaacccaa gacuacuaag aguagcacua       60

cuacuacuau uacuaguagc agcaagcaga agagcagcag gagcaccacu agcaacagaa      120

cucagaugcc aaugccuaca aacacuacaa ggaauacacc uaaaaaacau acaaagcgua      180

aaaguaaaau caccaggacc acacugcgca caaacagaag uaauagcaac acuaaaaaac      240

ggacaaaaag caugccuaaa cccagcauca ccaaugguca aaaaaauaau agaaaaaaug      300

cuaaaaaacg gaaaaucaaa cuaa                                             324


<210>  5209
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL2__Homo_sapiens__P19875

<400>  5209

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  5210
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL2__Homo_sapiens__AAA63182

<400>  5210
auggcccgcg ccacgcucuc cgccgccccc agcaaucccc ggcuccugcg aguggcgcug       60

cugcuccugc uccugguggc cgccagccgg cgcgcagcag gagcgccccu ggccacugaa      120

cugcgcugcc agugcuugca gacccugcag ggaauucacc ucaagaacau ccaaagugug      180

aaggugaagu cccccggacc ccacugcgcc caaaccgaag ucauagccac acucaagaau      240

gggcagaaag cuugucucaa ccccgcaucg cccaugguua agaaaaucau cgaaaagaug      300

cugaaaaaug gcaaauccaa cuga                                             324


<210>  5211
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5211
auggcccgcg ccacccugag cgcggccccc uccaacccgc ggcuccugcg cguggcccug       60

cuccugcugc uccuggucgc cgccagccgg cgcgcggccg gcgcgccccu ggccaccgag      120

cuccggugcc agugccugca gacgcugcag gggauccacc ucaagaacau ccaguccgug      180

aaggucaaga gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

gggcagaagg ccugccugaa cccggccucc cccaugguga agaagaucau cgagaagaug      300

cucaagaacg gcaagagcaa cuga                                             324


<210>  5212
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5212
auggcccgcg ccacccucuc cgccgccccc uccaaccccc gccuccuccg cgucgcccuc       60

cuccuccucc uccucgucgc cgccucccgc cgcgccgccg gcgccccccu cgccaccgag      120

cuccgcugcc agugccucca gacccuccag ggcauccacc ucaagaacau ccaguccguc      180

aaggucaagu cccccggccc ccacugcgcc cagaccgagg ucaucgccac ccucaagaac      240

ggccagaagg ccugccucaa ccccgccucc cccaugguca agaagaucau cgagaagaug      300

cucaagaacg gcaaguccaa cuga                                             324


<210>  5213
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5213
auggccagag cuacccugag cgcagccccc uccaacccua ggcuccuucg gguggcgcug       60

uuguuacugc uacucgucgc ugccucucgc cgagcagccg gcgcuccacu ggcaacagag      120

cuucguugcc agugucugca aacuuugcag gggauccacc ucaagaauau ucagucaguu      180

aaagugaaga guccgggacc ccauugcgcc cagacggaag uaauagcuac ccugaaaaac      240

ggucaaaagg ccugucugaa uccugcgagc ccaaugguga aaaagaucau ugagaagaug      300

cucaaaaacg gcaaguccaa uuga                                             324


<210>  5214
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5214
auggccagag ccacccugag cgccgccccc agcaacccca gacugcugag aguggcccug       60

cugcugcugc ugcugguggc cgccagcaga agagccgccg gcgccccccu ggccaccgag      120

cugagaugcc agugccugca gacccugcag ggcauccacc ugaagaacau ccagagcgug      180

aaggugaaga gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

ggccagaagg ccugccugaa ccccgccagc cccaugguga agaagaucau cgagaagaug      300

cugaagaacg gcaagagcaa cuga                                             324


<210>  5215
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5215
auggccagag cuacccugag cgccgcgccc uccaacccuc ggcuccugcg cguggcccuu       60

cugcuccugc uucuggucgc ugccucuaga cgggcugccg gggcuccgcu cgccacagag      120

cugcgcugcc agugucugca aacgcuccag gggauccacc ugaagaauau ucagagcguu      180

aaagugaagu cccccggacc ucauugcgcg cagaccgaag ugaucgccac acuuaaaaac      240

ggccaaaagg cuugucugaa ucccgccucu ccuaugguca aaaagauuau cgagaagaug      300

cucaaaaacg gcaagagcaa uuga                                             324


<210>  5216
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL2__Homo_sapiens__AAA63182

<400>  5216
auggcaagag caacacuaag cgcagcacca agcaacccaa gacuacuaag aguagcacua       60

cuacuacuac uacuaguagc agcaagcaga agagcagcag gagccccacu agcaacagaa      120

cuaagaugcc aaugccuaca aacacuacaa ggaauacacc uaaaaaacau acaaagcgua      180

aaaguaaaau caccaggacc acacugcgca caaacagaag uaauagcaac acuaaaaaac      240

ggacaaaaag caugccuaaa cccagcauca ccaaugguaa aaaaaauaau agaaaaaaug      300

cuaaaaaacg gaaaaucaaa cuaa                                             324


<210>  5217
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL3__Homo_sapiens__P19876

<400>  5217

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  5218
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL3__Homo_sapiens__AAH16308

<400>  5218
auggcccacg ccacgcucuc cgccgccccc agcaaucccc ggcuccugcg gguggcgcug       60

cugcuccugc uccugguggc cgccagccgg cgcgcagcag gagcguccgu ggucacugaa      120

cugcgcugcc agugcuugca gacacugcag ggaauucacc ucaagaacau ccaaagugug      180

aauguaaggu cccccggacc ccacugcgcc caaaccgaag ucauagccac acucaagaau      240

gggaagaaag cuugucucaa ccccgcaucc cccaugguuc agaaaaucau cgaaaagaua      300

cugaacaagg ggagcaccaa cuga                                             324


<210>  5219
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5219
auggcccacg ccacccugag cgcggccccc uccaacccgc gccuccugcg gguggcccug       60

cuccugcugc uccuggucgc cgccagccgc cgggcggccg gcgccuccgu ggugaccgag      120

cugcgcugcc agugccucca gacgcugcag gggauccacc ugaagaacau ccagagcguc      180

aacgugcggu cccccggccc ccacugcgcc cagaccgagg ugaucgcgac ccucaagaac      240

gggaagaagg ccugccugaa ccccgccagc ccgauggucc agaagaucau cgagaagauc      300

cugaacaagg gcuccaccaa cuga                                             324


<210>  5220
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5220
auggcccacg ccacccucuc cgccgccccc uccaaccccc gccuccuccg cgucgcccuc       60

cuccuccucc uccucgucgc cgccucccgc cgcgccgccg gcgccuccgu cgucaccgag      120

cuccgcugcc agugccucca gacccuccag ggcauccacc ucaagaacau ccaguccguc      180

aacguccgcu cccccggccc ccacugcgcc cagaccgagg ucaucgccac ccucaagaac      240

ggcaagaagg ccugccucaa ccccgccucc cccauggucc agaagaucau cgagaagauc      300

cucaacaagg gcuccaccaa cuga                                             324


<210>  5221
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5221
auggcccacg cuacccugag cgcagccccc uccaacccua gacuccuuag gguggcgcug       60

uuguuacugc uacucgucgc ugccucucgg cgcgcagccg gcgcuucagu ugugacagag      120

cugcgaugcc agugucuuca aacucugcag gggauccauu ugaagaauau ucagagugua      180

aacgugcgua gcccaggacc gcacugcgca cagacggaag ucauagccac ccucaaaaau      240

gguaagaaag ccugucugaa ccccgcuucc ccuauggugc aaaagaucau ugagaaaauc      300

cugaauaagg gcucuacaaa cuga                                             324


<210>  5222
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5222
auggcccacg ccacccugag cgccgccccc agcaacccca gacugcugag aguggcccug       60

cugcugcugc ugcugguggc cgccagcaga agagccgccg gcgccagcgu ggugaccgag      120

cugagaugcc agugccugca gacccugcag ggcauccacc ugaagaacau ccagagcgug      180

aacgugagaa gccccggccc ccacugcgcc cagaccgagg ugaucgccac ccugaagaac      240

ggcaagaagg ccugccugaa ccccgccagc cccauggugc agaagaucau cgagaagauc      300

cugaacaagg gcagcaccaa cuga                                             324


<210>  5223
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5223
auggcccacg cuacccugag cgccgcgccc uccaacccua gacuccugcg gguggcccuu       60

cugcuccugc uucuggucgc ugccucucgc agagcugccg gcgcuagcgu ugugacagag      120

cuccggugcc agugucugca aacgcugcag gggauccauc ucaagaauau ucaguccgug      180

aacguccgcu cuccgggacc ccacugcgcc cagaccgaag ugaucgcgac acugaaaaau      240

ggcaagaaag ccugucuuaa cccugcuagc cccaugguuc aaaagauuau cgagaaaauu      300

cugaauaagg gguccaccaa cuga                                             324


<210>  5224
<211>  324
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL3__Homo_sapiens__AAH16308

<400>  5224
auggcacacg caacacuaag cgcagcacca agcaacccaa gacuacuaag aguagcacua       60

cuacuacuac uacuaguagc agcaagcaga agagcagcag gagcaucagu aguaacagaa      120

cuaagaugcc aaugcuuaca aacacuacaa ggaauacacc uaaaaaacau acaaagcgua      180

aacguaagau caccaggacc acacugcgca caaacagaag uaauagcaac acuaaaaaac      240

ggaaaaaaag caugccuaaa cccagcauca ccaaugguac aaaaaauaau agaaaaaaua      300

cuaaacaaag gaagcacaaa cuaa                                             324


<210>  5225
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL4__Homo_sapiens__P02776

<400>  5225

Met Ser Ser Ala Ala Gly Phe Cys Ala Ser Arg Pro Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu Pro Leu Val Val Ala Phe Ala Ser Ala Glu 
            20                  25                  30          


Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys Thr Thr Ser 
        35                  40                  45              


Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile Lys Ala Gly 
    50                  55                  60                  


Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys Asn Gly Arg 
65                  70                  75                  80  


Lys Ile Cys Leu Asp Leu Gln Ala Pro Leu Tyr Lys Lys Ile Ile Lys 
                85                  90                  95      


Lys Leu Leu Glu Ser 
            100     


<210>  5226
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL4__Homo_sapiens__AAA60066

<400>  5226
augagcuccg cagccggguu cugcgccuca cgccccgggc ugcuguuccu gggguugcug       60

cuccugccac uuguggucgc cuucgccagc gcugaagcug aagaagaugg ggaccugcag      120

ugccugugug ugaagaccac cucccagguc cgucccaggc acaucaccag ccuggaggug      180

aucaaggccg gaccccacug ccccacugcc caacugauag ccacgcugaa gaauggaagg      240

aaaauuugcu uggaccugca agccccgcug uacaagaaaa uaauuaagaa acuuuuggag      300

aguuag                                                                 306


<210>  5227
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5227
augagcuccg ccgccggcuu cugcgcgagc cgccccgggc uccuguuccu gggccugcuc       60

cugcugccgc ucguggucgc cuucgccucc gccgaggccg aggaggacgg ggaccugcag      120

ugccugugcg ugaagaccac cagccaggug cggccccgcc acaucacguc ccucgagguc      180

aucaaggcgg gcccccacug ccccaccgcc cagcugaucg ccacccugaa gaacgggcgg      240

aagaucugcc ucgaccugca ggccccgcug uacaagaaga ucaucaagaa gcuccuggag      300

agcuga                                                                 306


<210>  5228
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5228
auguccuccg ccgccggcuu cugcgccucc cgccccggcc uccucuuccu cggccuccuc       60

cuccuccccc ucgucgucgc cuucgccucc gccgaggccg aggaggacgg cgaccuccag      120

ugccucugcg ucaagaccac cucccagguc cgcccccgcc acaucaccuc ccucgagguc      180

aucaaggccg gcccccacug ccccaccgcc cagcucaucg ccacccucaa gaacggccgc      240

aagaucugcc ucgaccucca ggccccccuc uacaagaaga ucaucaagaa gcuccucgag      300

uccuga                                                                 306


<210>  5229
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5229
augagcuccg ccgcuggcuu cugcgcaucu agacccgggc ugcucuuucu uggacuguug       60

uuacugccuc uaguggucgc cuucgcguca gcugaggccg aagaggacgg ugaucuccag      120

ugucugugcg uuaagaccac aagucaagug aggccacggc acaucacuag ccuugaagua      180

auuaaagcag gcccgcauug ucccacggcc cagcugauag cuaccuugaa gaacgggcgc      240

aaaaucugcc ucgaccugca ggcaccucug uacaagaaaa uuaucaagaa gcucuuagag      300

uccuga                                                                 306


<210>  5230
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5230
augagcagcg ccgccggcuu cugcgccagc agacccggcc ugcuguuccu gggccugcug       60

cugcugcccc uggugguggc cuucgccagc gccgaggccg aggaggacgg cgaccugcag      120

ugccugugcg ugaagaccac cagccaggug agacccagac acaucaccag ccuggaggug      180

aucaaggccg gcccccacug ccccaccgcc cagcugaucg ccacccugaa gaacggcaga      240

aagaucugcc uggaccugca ggccccccug uacaagaaga ucaucaagaa gcugcuggag      300

agcuga                                                                 306


<210>  5231
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5231
augagcuccg ccgccggcuu cugcgccucu agacccgggc ugcucuuucu gggacuucug       60

cuccugccuc uuguggucgc guucgcuagc gccgaggccg aagaggacgg cgaucugcag      120

ugucucugcg uuaagaccac aucccaagug cggccgcgcc acaucacguc ucuggaagug      180

auuaaagcug ggccccauug uccuaccgcc cagcugaucg cuacacucaa gaacggaaga      240

aaaauuugcc uggaccuuca ggcuccccug uacaagaaaa ucauuaagaa gcuccuggag      300

agcuga                                                                 306


<210>  5232
<211>  306
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL4__Homo_sapiens__AAA60066

<400>  5232
augucaucag cagcaggauu cugcgcauca agaccaggac uacuauuccu aggacuacua       60

cuacuaccau uaguaguagc auucgcauca gcagaagcag aagaagacgg agaccuacaa      120

ugccuaugcg uaaaaacaac aucacaagua agaccaagac acauaacauc acuagaagua      180

auaaaagcag gaccacacug cccaacagca caacuaauag caacacuaaa aaacggaaga      240

aaaauaugcc uagaccuaca agcaccacua uacaaaaaaa uaauaaaaaa acuacuagaa      300

ucauaa                                                                 306


<210>  5233
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL5__Homo_sapiens__P42830

<400>  5233

Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210>  5234
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL5__Homo_sapiens__AAA86426

<400>  5234
augagccucc uguccagccg cgcggcccgu guccccgguc cuucgagcuc cuugugcgcg       60

cuguuggugc ugcugcugcu gcugacgcag ccagggccca ucgccagcgc ugguccugcc      120

gcugcugugu ugagagagcu gcguugcguu uguuuacaga ccacgcaagg aguucauccc      180

aaaaugauca guaaucugca aguguucgcc auaggcccac agugcuccaa gguggaagug      240

guagccuccc ugaagaacgg gaaggaaauu ugucuugauc cagaagcccc uuuucuaaag      300

aaagucaucc agaaaauuuu ggacggugga aacaaggaaa acuga                      345


<210>  5235
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5235
augagccugc ucuccagccg cgccgcccgg gugcccggcc cguccagcuc ccugugcgcg       60

cugcucgucc ugcugcuccu gcugacccag cccgggccca ucgccagcgc cggccccgcc      120

gccgcggugc uccgcgagcu gcggugcgug ugccugcaga ccacgcaggg gguccacccg      180

aagaugaucu ccaaccucca gguguucgcc aucggccccc agugcagcaa gguggagguc      240

guggccuccc ugaagaacgg gaaggagauc ugccuggacc ccgaggcccc cuuccucaag      300

aaggugaucc agaagauccu ggacggcggc aacaaggaga acuga                      345


<210>  5236
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5236
augucccucc ucuccucccg cgccgcccgc guccccggcc ccuccuccuc ccucugcgcc       60

cuccucgucc uccuccuccu ccucacccag cccggcccca ucgccuccgc cggccccgcc      120

gccgccgucc uccgcgagcu ccgcugcguc ugccuccaga ccacccaggg cguccacccc      180

aagaugaucu ccaaccucca ggucuucgcc aucggccccc agugcuccaa ggucgagguc      240

gucgccuccc ucaagaacgg caaggagauc ugccucgacc ccgaggcccc cuuccucaag      300

aaggucaucc agaagauccu cgacggcggc aacaaggaga acuga                      345


<210>  5237
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5237
augagccugc ucuccucuag agccgcuagg gugcccggcc cuucaaguag ccuuugcgca       60

cuguuggucu uacugcuacu ccugacccag ccagggccga ucgccuccgc gggacccgcu      120

gccgcaguuc uucgggagcu gcgcugugug ugcuugcaaa caacucaggg uguacacccu      180

aagaugauuu cuaaccucca gguguucgcc auaggcccac aguguucgaa agucgaagug      240

guugcuucac ugaagaaugg gaaagagauc ugccuggacc ccgaagcacc uuuucucaag      300

aaagugauuc aaaagaucuu agauggaggc aacaaggaga auuga                      345


<210>  5238
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5238
augagccugc ugagcagcag agccgccaga gugcccggcc ccagcagcag ccugugcgcc       60

cugcuggugc ugcugcugcu gcugacccag cccggcccca ucgccagcgc cggccccgcc      120

gccgccgugc ugagagagcu gagaugcgug ugccugcaga ccacccaggg cgugcacccc      180

aagaugauca gcaaccugca gguguucgcc aucggccccc agugcagcaa gguggaggug      240

guggccagcc ugaagaacgg caaggagauc ugccuggacc ccgaggcccc cuuccugaag      300

aaggugaucc agaagauccu ggacggcggc aacaaggaga acuga                      345


<210>  5239
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5239
augagccugc ucuccucuag agccgcucgg gugcccggcc cuagcuccuc ucugugcgcc       60

cuucuggucc uccugcuucu gcucacccag ccggggccca ucgcgagcgc uggaccugcc      120

gccgcuguuc ugcgcgagcu gagaugugug ugccuccaaa caacgcaggg cgugcacccc      180

aagaugauuu ccaaccugca ggucuucgcc aucgggccuc aguguucuaa aguggaaguu      240

guggcuagcc uuaagaaugg aaaagagauu ugccuggacc ccgaagcccc uuuucucaag      300

aaagucaucc aaaagauucu ggauggcggg aacaaggaga auuga                      345


<210>  5240
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL5__Homo_sapiens__AAA86426

<400>  5240
augucacuac uaucaucaag agcagcaaga guaccaggac caucaucauc acuaugcgca       60

cuacuaguac uacuauuacu acuaacacaa ccaggaccaa uagcaucagc aggaccagca      120

gcagcaguac uaagagaacu aagaugcgua ugccuacaaa caacacaagg aguacaccca      180

aaaaugauau caaaccuaca aguauucgca auaggaccac aaugcucaaa aguagaagua      240

guagcaucac uaaaaaacgg aaaagaaaua ugccuagacc cagaagcacc auucuuaaaa      300

aaaguaauac aaaaaauacu agacggagga aacaaagaaa acuaa                      345


<210>  5241
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL5__Homo_sapiens__Q6I9S7

<400>  5241

Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210>  5242
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL5__Homo_sapiens__AAP35453

<400>  5242
augagccucc uguccagccg cgcggcccgu guccccgguc cuucgagcuc cuugugcgcg       60

cuguuggugc ugcugcugcu gcugacgcag ccagggccca ucgccagcgc ugguccugcc      120

gcugcugugu ugagagagcu gcguugcguu uguuuacaga ccacgcaagg aguucauccc      180

aaaaugauca guaaucugca aguguucgcc auaggcccac agugcuccaa gguggaagug      240

guagccuccc ugaagaacgg gaaggaaauu ugucuugauc cagaagcccc uuuucuaaag      300

aaagucaucc agaaaauuuu ggacggugga aacaaggaaa acuag                      345


<210>  5243
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5243
augagccugc ucuccagccg cgccgcccgg gugcccggcc cguccagcuc ccugugcgcg       60

cugcucgucc ugcugcuccu gcugacccag cccgggccca ucgccagcgc cggccccgcc      120

gccgcggugc uccgcgagcu gcggugcgug ugccugcaga ccacgcaggg gguccacccg      180

aagaugaucu ccaaccucca gguguucgcc aucggccccc agugcagcaa gguggagguc      240

guggccuccc ugaagaacgg gaaggagauc ugccuggacc ccgaggcccc cuuccucaag      300

aaggugaucc agaagauccu ggacggcggc aacaaggaga acuga                      345


<210>  5244
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5244
augucccucc ucuccucccg cgccgcccgc guccccggcc ccuccuccuc ccucugcgcc       60

cuccucgucc uccuccuccu ccucacccag cccggcccca ucgccuccgc cggccccgcc      120

gccgccgucc uccgcgagcu ccgcugcguc ugccuccaga ccacccaggg cguccacccc      180

aagaugaucu ccaaccucca ggucuucgcc aucggccccc agugcuccaa ggucgagguc      240

gucgccuccc ucaagaacgg caaggagauc ugccucgacc ccgaggcccc cuuccucaag      300

aaggucaucc agaagauccu cgacggcggc aacaaggaga acuga                      345


<210>  5245
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5245
augagccugc ucuccucuag agccgcuagg gugcccggcc cuucaaguag ccuuugcgca       60

cuguuggucu uacugcuacu ccugacccag ccagggccga ucgccuccgc gggacccgcu      120

gccgcaguuc uucgggagcu gcgcugugug ugcuugcaaa caacucaggg uguacacccu      180

aagaugauuu cuaaccucca gguguucgcc auaggcccac aguguucgaa agucgaagug      240

guugcuucac ugaagaaugg gaaagagauc ugccuggacc ccgaagcacc uuuucucaag      300

aaagugauuc aaaagaucuu agauggaggc aacaaggaga auuga                      345


<210>  5246
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5246
augagccugc ugagcagcag agccgccaga gugcccggcc ccagcagcag ccugugcgcc       60

cugcuggugc ugcugcugcu gcugacccag cccggcccca ucgccagcgc cggccccgcc      120

gccgccgugc ugagagagcu gagaugcgug ugccugcaga ccacccaggg cgugcacccc      180

aagaugauca gcaaccugca gguguucgcc aucggccccc agugcagcaa gguggaggug      240

guggccagcc ugaagaacgg caaggagauc ugccuggacc ccgaggcccc cuuccugaag      300

aaggugaucc agaagauccu ggacggcggc aacaaggaga acuga                      345


<210>  5247
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5247
augagccugc ucuccucuag agccgcucgg gugcccggcc cuagcuccuc ucugugcgcc       60

cuucuggucc uccugcuucu gcucacccag ccggggccca ucgcgagcgc uggaccugcc      120

gccgcuguuc ugcgcgagcu gagaugugug ugccuccaaa caacgcaggg cgugcacccc      180

aagaugauuu ccaaccugca ggucuucgcc aucgggccuc aguguucuaa aguggaaguu      240

guggcuagcc uuaagaaugg aaaagagauu ugccuggacc ccgaagcccc uuuucucaag      300

aaagucaucc aaaagauucu ggauggcggg aacaaggaga auuga                      345


<210>  5248
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL5__Homo_sapiens__AAP35453

<400>  5248
augucacuac uaucaucaag agcagcaaga guaccaggac caucaucauc acuaugcgca       60

cuacuaguac uacuacuauu auuaacacaa ccaggaccaa uagcaucagc aggaccagca      120

gcagcaguac uaagagaacu aagaugcgua ugccuacaaa caacacaagg aguacaccca      180

aaaaugauau caaaccuaca aguauucgca auaggaccac aaugcucaaa aguagaagua      240

guagcaucac uaaaaaacgg aaaagaaaua ugccuagacc cagaagcacc auuccuaaaa      300

aaaguaauac aaaaaauacu agacggagga aacaaagaaa acuaa                      345


<210>  5249
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL6__Homo_sapiens__P80162

<400>  5249

Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 
        35                  40                  45              


Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 
            100                 105                 110         


Lys Asn 
        


<210>  5250
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL6__Homo_sapiens__AAC51338

<400>  5250
augagccucc cguccagccg cgcggcccgu gucccggguc cuucgggcuc cuugugcgcg       60

cugcucgcgc ugcugcuccu gcugacgccg ccggggcccc ucgccagcgc ugguccuguc      120

ucugcugugc ugacagagcu gcguugcacu uguuuacgcg uuacgcugag aguaaacccc      180

aaaacgauug guaaacugca gguguucccc gcaggcccgc agugcuccaa gguggaagug      240

guagccuccc ugaagaacgg gaagcaaguu ugucuggacc cggaagcccc uuuucuaaag      300

aaagucaucc agaaaauuuu ggacagugga aacaagaaaa acuga                      345


<210>  5251
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5251
augagccugc ccuccagccg cgccgcccgg gugccgggcc ccuccgggag ccucugcgcg       60

cugcuggccc uccugcugcu ccugaccccg cccggccccc uggccuccgc cgggcccguc      120

agcgccgugc ucaccgagcu gcgcugcacg ugccugcggg ugacccuccg cgucaacccc      180

aagaccaucg gcaagcucca gguguucccc gcggggccgc agugcuccaa gguggagguc      240

guggccagcc ugaagaacgg caagcagguc ugccuggacc ccgaggcccc cuuccugaag      300

aaggugaucc agaagauccu ggacuccggc aacaagaaga acuga                      345


<210>  5252
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5252
augucccucc ccuccucccg cgccgcccgc guccccggcc ccuccggcuc ccucugcgcc       60

cuccucgccc uccuccuccu ccucaccccc cccggccccc ucgccuccgc cggccccguc      120

uccgccgucc ucaccgagcu ccgcugcacc ugccuccgcg ucacccuccg cgucaacccc      180

aagaccaucg gcaagcucca ggucuucccc gccggccccc agugcuccaa ggucgagguc      240

gucgccuccc ucaagaacgg caagcagguc ugccucgacc ccgaggcccc cuuccucaag      300

aaggucaucc agaagauccu cgacuccggc aacaagaaga acuga                      345


<210>  5253
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5253
augagccugc ccuccucuag agccgcuagg gugccuggcc caucagggag ucucugcgca       60

cuucuggccu uguuacugcu acucaccccg cccggaccuc uggcgagcgc ugguccaguc      120

uccgccguuc uuacagagcu gcgguguacu ugcuugcgcg ugacgcuccg aguaaacccc      180

aagaccaucg gcaaauuaca gguguucccu gcagggccac aauguucuaa ggucgaagug      240

guugccucgc ugaaaaaugg aaaacaggug ugccucgacc ccgaggcucc uuuucugaag      300

aaggucauuc agaagauacu ggauucaggc aacaaaaaga auuga                      345


<210>  5254
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5254
augagccugc ccagcagcag agccgccaga gugcccggcc ccagcggcag ccugugcgcc       60

cugcuggccc ugcugcugcu gcugaccccc cccggccccc uggccagcgc cggccccgug      120

agcgccgugc ugaccgagcu gagaugcacc ugccugagag ugacccugag agugaacccc      180

aagaccaucg gcaagcugca gguguucccc gccggccccc agugcagcaa gguggaggug      240

guggccagcc ugaagaacgg caagcaggug ugccuggacc ccgaggcccc cuuccugaag      300

aaggugaucc agaagauccu ggacagcggc aacaagaaga acuga                      345


<210>  5255
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5255
augagccugc ccuccucuag agccgcucgg gugccuggcc cgagcggguc ccucugcgcc       60

cugcuugcgc ugcuccugcu ucugacaccc ccuggacccc ucgcuucugc cggcccuguc      120

agcgccguuc ugaccgagcu gcgcuguacg ugccucagag ugacccugcg ggugaacccc      180

aagacaaucg ggaaacuuca ggucuucccu gcuggaccgc aauguuccaa gguggaaguu      240

guggccucuc ugaaaaaugg caagcagguc ugccucgacc ccgaggcucc uuuucugaaa      300

aaggugauuc agaagauccu ugauagcggg aacaaaaaga auuga                      345


<210>  5256
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL6__Homo_sapiens__AAC51338

<400>  5256
augucacuac caucaucaag agcagcaaga guaccaggac caucaggaag ccuaugcgca       60

uuacuagcac uacuacuacu acuaacacca ccaggaccac uagcaucagc aggaccagua      120

ucagcaguac uaacagaacu aagaugcaca ugccuaagag uaacacuaag aguaaaccca      180

aaaacaauag gaaaacuaca aguauuccca gcaggaccac aaugcucaaa aguagaagua      240

guagcaucac uaaaaaacgg aaaacaagua ugccuagacc cagaagcacc auuccuaaaa      300

aaaguaauac aaaaaauacu agacucagga aacaaaaaaa acuaa                      345


<210>  5257
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL7__Homo_sapiens__P02775

<400>  5257

Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             






<210>  5258
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL7__Homo_sapiens__AAA62836

<400>  5258
augagccuca gacuugauac caccccuucc uguaacagug cgagaccacu ucaugccuug       60

caggugcugc ugcuucuguc auugcugcug acugcucugg cuuccuccac caaaggacaa      120

acuaagagaa acuuggcgaa aggcaaagag gaaagucuag acagugacuu guaugcugaa      180

cuccgcugca uguguauaaa gacaaccucu ggaauucauc ccaaaaacau ccaaaguuug      240

gaagugaucg ggaaaggaac ccauugcaac caagucgaag ugauagccac acugaaggau      300

gggaggaaaa ucugccugga cccagaugcu cccagaauca agaaaauugu acagaaaaaa      360

uuggcaggug augaaucugc ugauuaa                                          387


<210>  5259
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5259
augagccugc gccucgacac cacccccucc ugcaacagcg cccggccgcu gcacgcccuc       60

caggugcugc ugcugcucuc ccugcugcuc acggcgcugg ccagcuccac caagggccag      120

accaagcgca accuggccaa ggggaaggag gagagccucg acuccgaccu guacgccgag      180

cugcggugca ugugcaucaa gaccacgagc ggcauccacc ccaagaacau ccagucccuc      240

gaggucaucg ggaagggcac ccacugcaac cagguggagg ugaucgccac ccugaaggac      300

gggcgcaaga ucugccugga ccccgacgcg ccccggauca agaagaucgu ccagaagaag      360

cucgccggcg acgagagcgc cgacuga                                          387


<210>  5260
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5260
augucccucc gccucgacac cacccccucc ugcaacuccg cccgcccccu ccacgcccuc       60

cagguccucc uccuccucuc ccuccuccuc accgcccucg ccuccuccac caagggccag      120

accaagcgca accucgccaa gggcaaggag gagucccucg acuccgaccu cuacgccgag      180

cuccgcugca ugugcaucaa gaccaccucc ggcauccacc ccaagaacau ccagucccuc      240

gaggucaucg gcaagggcac ccacugcaac caggucgagg ucaucgccac ccucaaggac      300

ggccgcaaga ucugccucga ccccgacgcc ccccgcauca agaagaucgu ccagaagaag      360

cucgccggcg acgaguccgc cgacuga                                          387


<210>  5261
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5261
augagccuga gacucgacac cacacccucc ugcaacucug ccaggccucu ucacgcucug       60

caaguguugu uacugcuauc acuccugcuu acugcacugg ccaguagcac gaagggccag      120

accaaacgga auuuggcgaa ggggaaagag gaaucccucg auucugaccu guacgcugag      180

cugcgcugua ugugcaucaa gacaacuucg gguauucauc cgaaaaacau acagucacuc      240

gaagucaucg gaaagggcac ccacuguaau cagguugagg ugauugccac auuaaaggau      300

gggcgaaaaa ucugccugga cccagaugca ccccguauua agaaaaucgu acagaagaaa      360

cuugccggag acgaaagcgc ugauuga                                          387


<210>  5262
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5262
augagccuga gacuggacac cacccccagc ugcaacagcg ccagaccccu gcacgcccug       60

caggugcugc ugcugcugag ccugcugcug accgcccugg ccagcagcac caagggccag      120

accaagagaa accuggccaa gggcaaggag gagagccugg acagcgaccu guacgccgag      180

cugagaugca ugugcaucaa gaccaccagc ggcauccacc ccaagaacau ccagagccug      240

gaggugaucg gcaagggcac ccacugcaac cagguggagg ugaucgccac ccugaaggac      300

ggcagaaaga ucugccugga ccccgacgcc cccagaauca agaagaucgu gcagaagaag      360

cuggccggcg acgagagcgc cgacuga                                          387


<210>  5263
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5263
augagccuga gacucgacac cacacccucc ugcaacucug cccggccucu gcacgcccuu       60

caggugcugc uccugcuuag ccugcuccug acggcucugg cguccucuac caagggccaa      120

acaaaacgca aucucgcuaa ggggaaagag gaaagccugg auuccgaccu uuacgccgag      180

cugagaugua ugugcaucaa gaccacaucu ggcauucauc cgaaaaacau ccagagccuc      240

gaagucauug gaaaggggac ccacuguaau cagguugagg ugaucgccac acugaaggau      300

ggacggaaaa uuugccuuga ccccgaugcu ccucgcauca agaaaaucgu gcagaagaaa      360

cuggccggcg acgaauccgc ugauuga                                          387


<210>  5264
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL7__Homo_sapiens__AAA62836

<400>  5264
augucacuaa gacucgacac aacaccauca ugcaacucag caagaccacu acacgcacua       60

caaguacuac uacuacuaag ccuacuacua acagcacuag caagcucaac aaaaggacaa      120

acaaaaagaa accuagcaaa aggaaaagaa gaaucacuag acagcgaccu auacgcagaa      180

cuaagaugca ugugcauaaa aacaacauca ggaauacacc caaaaaacau acaaagcuua      240

gaaguaauag gaaaaggaac acacugcaac caaguagaag uaauagcaac acuaaaagac      300

ggaagaaaaa uaugccuaga cccagacgca ccaagaauaa aaaaaauagu acaaaaaaaa      360

cuagcaggag acgaaucagc agacuaa                                          387


<210>  5265
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL8__Homo_sapiens__P10145

<400>  5265

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  5266
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL8__Homo_sapiens__AAA35611

<400>  5266
augacuucca agcuggccgu ggcucucuug gcagccuucc ugauuucugc agcucugugu       60

gaaggugcag uuuugccaag gagugcuaaa gaacuuagau gucagugcau aaagacauac      120

uccaaaccuu uccaccccaa auuuaucaaa gaacugagag ugauugagag uggaccacac      180

ugcgccaaca cagaaauuau uguaaagcuu ucugauggaa gagagcucug ucuggacccc      240

aaggaaaacu gggugcagag gguuguggag aaguuuuuga agagggcuga gaauucauaa      300


<210>  5267
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5267
augaccagca agcuggccgu ggcccuccug gcggccuucc ugaucuccgc cgcccucugc       60

gagggcgccg uccugccccg cagcgcgaag gagcugcggu gccagugcau caagaccuac      120

uccaagccgu uccaccccaa guucaucaag gagcuccgcg ugaucgagag cgggccccac      180

ugcgccaaca cggagaucau cgugaagcug uccgacggcc gggagcugug ccucgacccc      240

aaggagaacu ggguccagcg cgugguggag aaguuccuga agcgggccga gaacagcuga      300


<210>  5268
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5268
augaccucca agcucgccgu cgcccuccuc gccgccuucc ucaucuccgc cgcccucugc       60

gagggcgccg uccucccccg cuccgccaag gagcuccgcu gccagugcau caagaccuac      120

uccaagcccu uccaccccaa guucaucaag gagcuccgcg ucaucgaguc cggcccccac      180

ugcgccaaca ccgagaucau cgucaagcuc uccgacggcc gcgagcucug ccucgacccc      240

aaggagaacu ggguccagcg cgucgucgag aaguuccuca agcgcgccga gaacuccuga      300


<210>  5269
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5269
augaccagca agcuggccgu ggcucuccuu gcagccuucc ugaucuccgc ggcuuugugc       60

gagggcgccg ucuuacccag aucugcaaaa gaacugaggu gucagugcau uaagacauac      120

ucaaaaccuu uucacccaaa guucauaaaa gagcuacggg uuaucgaaag ugggccgcau      180

ugugccaaca cugagauuau cgugaagcuc agcgacggac gcgaacugug ccuugauccc      240

aaggagaauu ggguacaacg aguggucgag aaauuucuga agcgugcuga aaacuccuga      300


<210>  5270
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5270
augaccagca agcuggccgu ggcccugcug gccgccuucc ugaucagcgc cgcccugugc       60

gagggcgccg ugcugcccag aagcgccaag gagcugagau gccagugcau caagaccuac      120

agcaagcccu uccaccccaa guucaucaag gagcugagag ugaucgagag cggcccccac      180

ugcgccaaca ccgagaucau cgugaagcug agcgacggca gagagcugug ccuggacccc      240

aaggagaacu gggugcagag agugguggag aaguuccuga agagagccga gaacagcuga      300


<210>  5271
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5271
augaccagca agcuggccgu ggcucuccug gccgcguucc uuaucuccgc ugcccugugc       60

gagggcgccg uccuccccag aucugcuaaa gaacugcggu gucagugcau uaagacauac      120

agcaaaccuu uucacccgaa guucaucaaa gagcuucgcg uuauugaauc cgggccccau      180

ugugccaaca cggagaucau ugugaagcug ucugacggaa gagaacucug ccuggauccu      240

aaggagaauu gggugcaacg ggucguggag aaauuucuga agcgcgcuga aaacagcuga      300


<210>  5272
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL8__Homo_sapiens__AAA35611

<400>  5272
augacaucaa aacuagcagu agcacuacua gcagcauucc uaauaucagc agcacuaugc       60

gaaggagcag uacuaccaag aucagcaaaa gaauuaagau gccaaugcau aaaaacauac      120

ucaaaaccau uccacccaaa auucauaaaa gaacuaagag uaauagaauc aggaccacac      180

ugcgcaaaca cagaaauaau aguaaaacua ucagacggaa gagaacuaug ccuagaccca      240

aaagaaaacu ggguacaaag aguaguagaa aaauuccuaa aaagagcaga aaacucauaa      300


<210>  5273
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL9__Homo_sapiens__L8E8X0

<400>  5273

Met Met Gln His Pro Cys Leu Phe Met Thr Gly Cys Leu Leu Ser Phe 
1               5                   10                  15      


Ser Asn Asn Lys Lys His Val Val Lys His Leu Arg Ile Phe Trp Thr 
            20                  25                  30          


Val Phe Lys Lys Tyr Thr Val Tyr Arg Lys Ser Tyr Asn Leu Thr Met 
        35                  40                  45              


Lys Arg Thr Leu 
    50          


<210>  5274
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL9__Homo_sapiens__CCQ43176

<400>  5274
augaugcaac auccuugucu uuuuaugaca ggauguuugc ucagcuucuc caacaauaag       60

aagcacgugg uaaaacacuu gcggauauuc uggacuguuu uuaaaaaaua uacaguuuac      120

cgaaaaucau auaaucuuac aaugaaaagg acuuuauag                             159


<210>  5275
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5275
augaugcagc accccugccu guucaugacc ggcugccucc ugagcuucuc caacaacaag       60

aagcacgugg ucaagcaccu ccgcaucuuc uggaccgugu ucaagaagua cacgguguac      120

cgcaagagcu acaaccugac caugaagcgg acccuguga                             159


<210>  5276
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5276
augaugcagc accccugccu cuucaugacc ggcugccucc ucuccuucuc caacaacaag       60

aagcacgucg ucaagcaccu ccgcaucuuc uggaccgucu ucaagaagua caccgucuac      120

cgcaaguccu acaaccucac caugaagcgc acccucuga                             159


<210>  5277
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5277
augaugcagc accccugccu guucaugacc ggcugucucc uuagcuuuuc caacaauaag       60

aaacaugugg ucaagcaccu gagaaucuuc uggacaguuu uuaaaaagua cacuguguau      120

aggaaaucuu acaacuugac gaugaagcgg accuuauga                             159


<210>  5278
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5278
augaugcagc accccugccu guucaugacc ggcugccugc ugagcuucag caacaacaag       60

aagcacgugg ugaagcaccu gagaaucuuc uggaccgugu ucaagaagua caccguguac      120

agaaagagcu acaaccugac caugaagaga acccuguga                             159


<210>  5279
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5279
augaugcagc accccugccu guucaugacc ggcugucucc ugagcuuuuc caacaauaag       60

aaacaugugg ucaagcaccu uagaaucuuc uggacaguuu uuaaaaagua cacgguguau      120

cggaaaucuu acaaccugac caugaagcgc acacucuga                             159


<210>  5280
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL9__Homo_sapiens__CCQ43176

<400>  5280
augaugcaac acccaugccu auucaugacc ggaugccuac uaucauucuc aaacaacaaa       60

aaacacguag ucaaacaccu aagaauauuc uggacaguau ucaaaaaaua cacaguauac      120

agaaaaucau acaaccuaac aaugaaaaga acacuauaa                             159


<210>  5281
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CXCL9__Homo_sapiens__Q07325

<400>  5281

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  5282
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CXCL9__Homo_sapiens__AAH63122

<400>  5282
augaagaaaa gugguguucu uuuccucuug ggcaucaucu ugcugguucu gauuggagug       60

caaggaaccc caguagugag aaagggucgc uguuccugca ucagcaccaa ccaagggacu      120

auccaccuac aauccuugaa agaccuuaaa caauuugccc caagcccuuc cugcgagaaa      180

auugaaauca uugcuacacu gaagaaugga guucaaacau gucuaaaccc agauucagca      240

gaugugaagg aacugauuaa aaagugggag aaacagguca gccaaaagaa aaagcaaaag      300

aaugggaaaa aacaucaaaa aaagaaaguu cugaaaguuc gaaaaucuca acguucucgu      360

caaaagaaga cuacauaa                                                    378


<210>  5283
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5283
augaagaagu ccggcgugcu guuccuccug gggaucaucc ugcucguccu gaucggcgug       60

caggggaccc ccgugguccg caagggccgg ugcagcugca ucagcaccaa ccaggggacg      120

auccaccucc agucccugaa ggaccugaag caguucgccc cgagccccuc cugcgagaag      180

aucgagauca ucgccacccu gaagaacggc gugcagaccu gccucaaccc cgacagcgcg      240

gacgugaagg agcugaucaa gaagugggag aagcaggucu cccagaagaa gaagcagaag      300

aacggcaaga agcaccagaa gaagaaggug cugaaggugc gcaagagcca gcggucccgc      360

cagaagaaga ccacguga                                                    378


<210>  5284
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5284
augaagaagu ccggcguccu cuuccuccuc ggcaucaucc uccucguccu caucggcguc       60

cagggcaccc ccgucguccg caagggccgc ugcuccugca ucuccaccaa ccagggcacc      120

auccaccucc agucccucaa ggaccucaag caguucgccc ccucccccuc cugcgagaag      180

aucgagauca ucgccacccu caagaacggc guccagaccu gccucaaccc cgacuccgcc      240

gacgucaagg agcucaucaa gaagugggag aagcaggucu cccagaagaa gaagcagaag      300

aacggcaaga agcaccagaa gaagaagguc cucaaggucc gcaaguccca gcgcucccgc      360

cagaagaaga ccaccuga                                                    378


<210>  5285
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5285
augaagaaaa gcggcgugcu guuccuccuu gggauaauuc uguuggucuu aauaggaguu       60

caggguaccc ccgugguaag aaaggggagg ugcuccugua ucucuacaaa ccaaggcacu      120

auucaucugc agucacuaaa agaccucaag caguuugccc cuaguccaag cugcgagaaa      180

aucgaaauua ucgcuacgcu gaagaaugga gugcagaccu gucuuaaccc ggauuccgca      240

gacgucaagg agcugaucaa aaagugggaa aaacaagugu cucagaagaa aaagcagaag      300

aauggcaaaa agcaccagaa aaagaaaguu uugaaggugc ggaaaucgca acgcucacga      360

cagaagaaga caacuuga                                                    378


<210>  5286
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5286
augaagaaga gcggcgugcu guuccugcug ggcaucaucc ugcuggugcu gaucggcgug       60

cagggcaccc ccguggugag aaagggcaga ugcagcugca ucagcaccaa ccagggcacc      120

auccaccugc agagccugaa ggaccugaag caguucgccc ccagccccag cugcgagaag      180

aucgagauca ucgccacccu gaagaacggc gugcagaccu gccugaaccc cgacagcgcc      240

gacgugaagg agcugaucaa gaagugggag aagcagguga gccagaagaa gaagcagaag      300

aacggcaaga agcaccagaa gaagaaggug cugaagguga gaaagagcca gagaagcaga      360

cagaagaaga ccaccuga                                                    378


<210>  5287
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5287
augaagaaaa gcggcgugcu guuccuccug gggaucauuc uucugguccu caucggaguu       60

cagggcaccc ccguggugag aaaggggcgg ugcuccugua uuucuacaaa ccaaggaacg      120

auccaucugc agagccuuaa agaccugaag caguuugccc cuuccccguc uugcgagaaa      180

auugaaauca ucgcuacccu caagaauggc guccagacau gucugaaccc cgauagcgcc      240

gacgugaagg agcugauuaa aaagugggaa aaacaaguuu cccagaagaa aaagcagaag      300

aaugggaaaa agcaccagaa aaagaaagug cucaaggucc gcaaaucuca aagaagccgg      360

cagaagaaga ccacauga                                                    378


<210>  5288
<211>  378
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       CXCL9__Homo_sapiens__AAH63122

<400>  5288
augaaaaaau caggaguacu auuccuacua ggaauaauac uacuaguacu aauaggagua       60

caaggaacac caguaguaag aaaaggaaga ugcagcugca uaucaacaaa ccaaggaaca      120

auacaccuac aaucacuaaa agaccuaaaa caauucgcac caucaccauc augcgaaaaa      180

auagaaauaa uagcaacacu aaaaaacgga guacaaacau gccuaaaccc agacucagca      240

gacguaaaag aauuaauaaa aaaaugggaa aaacaaguaa gccaaaaaaa aaaacaaaaa      300

aauggaaaaa aacaccaaaa aaaaaaagua cuaaaaguaa gaaaaagcca aagaucaaga      360

caaaaaaaaa ccacauaa                                                    378


<210>  5289
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  XCL1__Homo_sapiens__P47992

<400>  5289

Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      


Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys 
            20                  25                  30          


Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              


Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  


Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  


Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      


Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         


Thr Gly 
        


<210>  5290
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  XCL1__Homo_sapiens__AAC50164

<400>  5290
augagacuuc ucauccuggc ccuccuuggc aucugcucuc ucacugcaua cauuguggaa       60

gguguaggga gugaagucuc agauaagagg accuguguga gccucacuac ccagcgacug      120

ccgguuagca gaaucaagac cuacaccauc acggaaggcu ccuugagagc aguaauuuuu      180

auuaccaaac guggccuaaa agucugugcu gauccacaag ccacgugggu gagagacgug      240

gucaggagca uggacaggaa auccaacacc agaaauaaca ugauccagac caagccaaca      300

ggaacccagc aaucgaccaa uacagcugug acccugacug gcuag                      345


<210>  5291
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       XCL1__Homo_sapiens__AAC50164

<400>  5291
augcgccugc ucauccuggc ccugcucggc aucugcagcc ugaccgccua caucguggag       60

ggggucggcu ccgaggugag cgacaagcgg accugcgugu cccugacgac ccagcgccuc      120

cccgucagcc ggaucaagac cuacaccauc acggaggggu cccugcgcgc ggugaucuuc      180

aucaccaagc ggggccugaa ggugugcgcc gacccgcagg ccaccugggu ccgcgacgug      240

gugcggagca uggaccgcaa guccaacacc cggaacaaca ugauccagac gaagcccacc      300

gggacccagc agagcaccaa cacggccguc acccucaccg gcuga                      345


<210>  5292
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       XCL1__Homo_sapiens__AAC50164

<400>  5292
augcgccucc ucauccucgc ccuccucggc aucugcuccc ucaccgccua caucgucgag       60

ggcgucggcu ccgaggucuc cgacaagcgc accugcgucu cccucaccac ccagcgccuc      120

cccgucuccc gcaucaagac cuacaccauc accgagggcu cccuccgcgc cgucaucuuc      180

aucaccaagc gcggccucaa ggucugcgcc gacccccagg ccaccugggu ccgcgacguc      240

guccgcucca uggaccgcaa guccaacacc cgcaacaaca ugauccagac caagcccacc      300

ggcacccagc aguccaccaa caccgccguc acccucaccg gcuga                      345


<210>  5293
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       XCL1__Homo_sapiens__AAC50164

<400>  5293
augagacugc ucauccuugc ccuguugggc auuugcagcu uaaccgcuua cauaguggag       60

ggggucggau ccgaaguuuc ugacaagagg acaugugugu cacugacuac gcagcggcua      120

cccguaaguc gcaucaaaac cuauacaauu acugagggua gccuccgagc agugaucuuc      180

auuaccaagc guggccugaa agucugcgcc gauccucaag cgacaugggu gagagacguu      240

gugaggucca uggaucggaa gucuaacacc cgcaauaaca ugauccagac uaaaccaaca      300

gggacccagc agucgacgaa uacugcuguc acccuuacag gauga                      345


<210>  5294
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       XCL1__Homo_sapiens__AAC50164

<400>  5294
augagacugc ugauccuggc ccugcugggc aucugcagcc ugaccgccua caucguggag       60

ggcgugggca gcgaggugag cgacaagaga accugcguga gccugaccac ccagagacug      120

cccgugagca gaaucaagac cuacaccauc accgagggca gccugagagc cgugaucuuc      180

aucaccaaga gaggccugaa ggugugcgcc gacccccagg ccaccugggu gagagacgug      240

gugagaagca uggacagaaa gagcaacacc agaaacaaca ugauccagac caagcccacc      300

ggcacccagc agagcaccaa caccgccgug acccugaccg gcuga                      345


<210>  5295
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       XCL1__Homo_sapiens__AAC50164

<400>  5295
augagacugc ucauccuggc ccuucugggc auuugcagcc ucaccgcuua caucguggag       60

ggggucggau ccgaaguuuc ugacaagcgg acauguguga gccugacgac ccagcgccuu      120

cccgugucca gaauuaaaac auauaccauc acagagggcu cucugcgggc cgucauuuuc      180

aucaccaagc gcgggcucaa agugugcgcg gauccucaag cuacaugggu uagagacgug      240

guccggagca uggaucgcaa guccaacacc agaaauaaca ugauccagac gaaaccgacc      300

ggaacacagc agucuaccaa uacagccgug acccugacgg gcuga                      345


<210>  5296
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       XCL1__Homo_sapiens__AAC50164

<400>  5296
augagacuac uaauacuagc auuacuagga auaugcucac uaacagcaua cauaguagaa       60

ggaguaggaa gcgaaguauc agacaaaaga acaugcguaa gccuaacaac acaaagacua      120

ccaguaucaa gaauaaaaac auacacaaua acagaaggaa gccuaagagc aguaauauuc      180

auaacaaaaa gaggacuaaa aguaugcgca gacccacaag caacaugggu aagagacgua      240

guaagaucaa uggacagaaa aagcaacaca agaaacaaca ugauacaaac aaaaccaaca      300

ggaacacaac aaucaacaaa cacagcagua acacuaacag gauaa                      345


<210>  5297
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  XCL2__Homo_sapiens__Q9UBD3

<400>  5297

Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      


Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser His Arg Arg Thr Cys 
            20                  25                  30          


Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              


Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  


Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  


Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      


Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         


Thr Gly 
        


<210>  5298
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  XCL2__Homo_sapiens__AAH69360

<400>  5298
augagacuuc ucauccuggc ccuccuuggc aucugcucuc ucacugcaua cauuguggaa       60

gguguaggga gugaagucuc acauaggagg accuguguga gccucacuac ccagcgacug      120

ccaguuagca gaaucaagac cuacaccauc acggaaggcu ccuugagagc aguaauuuuu      180

auuaccaaac guggccuaaa agucugugcu gauccacaag ccacgugggu gagagacgug      240

gucaggagca uggacaggaa auccaacacc agaaauaaca ugauccagac caagccaaca      300

ggaacccagc aaucgaccaa uacagcugug acccugacug gcuag                      345


<210>  5299
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       XCL2__Homo_sapiens__AAH69360

<400>  5299
augcgccugc ucauccuggc ccugcucggc aucugcagcc ugaccgccua caucguggag       60

ggggucggcu ccgaggugag ccaccggcgg accugcgugu cccugacgac ccagcgccuc      120

cccgucagcc gcaucaagac cuacaccauc acggaggggu cccugcgggc ggugaucuuc      180

aucaccaagc gcggccugaa ggugugcgcc gacccgcagg ccaccugggu ccgggacgug      240

gugcgcagca uggaccggaa guccaacacc cgcaacaaca ugauccagac gaagcccacc      300

gggacccagc agagcaccaa cacggccguc acccucaccg gcuga                      345


<210>  5300
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       XCL2__Homo_sapiens__AAH69360

<400>  5300
augcgccucc ucauccucgc ccuccucggc aucugcuccc ucaccgccua caucgucgag       60

ggcgucggcu ccgaggucuc ccaccgccgc accugcgucu cccucaccac ccagcgccuc      120

cccgucuccc gcaucaagac cuacaccauc accgagggcu cccuccgcgc cgucaucuuc      180

aucaccaagc gcggccucaa ggucugcgcc gacccccagg ccaccugggu ccgcgacguc      240

guccgcucca uggaccgcaa guccaacacc cgcaacaaca ugauccagac caagcccacc      300

ggcacccagc aguccaccaa caccgccguc acccucaccg gcuga                      345


<210>  5301
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       XCL2__Homo_sapiens__AAH69360

<400>  5301
augagacugc ucauccuugc ccuguugggc auuugcagcu uaaccgcuua cauaguggag       60

ggggucggau ccgaaguuuc ucacaggcgg acaugugugu cacugacuac gcagcgccua      120

cccguaaguc gaaucaagac cuauacaauu acugagggua gccuccgugc agugaucuuc      180

auuaccaaaa gaggccugaa ggucugcgcc gacccucaag cgacaugggu gagggauguu      240

gugcggucca uggaccgcaa aucuaacacc agaaauaaca ugauccagac uaagccaaca      300

gggacccagc agucgacgaa uacugcuguc acccuuacag gauga                      345


<210>  5302
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       XCL2__Homo_sapiens__AAH69360

<400>  5302
augagacugc ugauccuggc ccugcugggc aucugcagcc ugaccgccua caucguggag       60

ggcgugggca gcgaggugag ccacagaaga accugcguga gccugaccac ccagagacug      120

cccgugagca gaaucaagac cuacaccauc accgagggca gccugagagc cgugaucuuc      180

aucaccaaga gaggccugaa ggugugcgcc gacccccagg ccaccugggu gagagacgug      240

gugagaagca uggacagaaa gagcaacacc agaaacaaca ugauccagac caagcccacc      300

ggcacccagc agagcaccaa caccgccgug acccugaccg gcuga                      345


<210>  5303
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       XCL2__Homo_sapiens__AAH69360

<400>  5303
augagacugc ucauccuggc ccuucugggc auuugcagcc ucaccgcuua caucguggag       60

ggggucggau ccgaaguuuc ucaccggcgc acauguguga gccugacgac ccagagacuu      120

cccguguccc ggauuaagac auauaccauc acagagggcu cucugcgcgc cgucauuuuc      180

aucaccaaaa gagggcucaa ggugugcgcg gacccucaag cuacaugggu ucgggaugug      240

guccgcagca uggacagaaa auccaacacc cggaauaaca ugauccagac gaagccgacc      300

ggaacacagc agucuaccaa uacagccgug acccugacgg gcuga                      345


<210>  5304
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       XCL2__Homo_sapiens__AAH69360

<400>  5304
augagacuac uaauacuagc acuauuagga auaugcucac uaacagcaua cauaguagaa       60

ggaguaggaa gcgaaguauc acacagaaga acaugcguaa gucuaacaac acaaagacua      120

ccaguaucaa gaauaaaaac auacacaaua acagaaggaa gucuaagagc aguaauauuc      180

auaacaaaaa gaggacuaaa aguaugcgca gacccacaag caacaugggu aagagacgua      240

guaagaucaa uggacagaaa aagcaacaca agaaacaaca ugauacaaac aaaaccaaca      300

ggaacacaac aaucaacaaa cacagcagua acacuaacag gauaa                      345


<210>  5305
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__A0A024KS17

<400>  5305

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Arg Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu Gln Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala Tyr 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Ile 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5306
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5306
auguggaggc uaacaguguc gaauaacgcu uuacaaacaa uuauuaacgc ccgguuacca       60

ggcaaagagg ggcuguggca gauucaucug caggacggaa aaaucagcgc cauugaugcg      120

caauccggcg ugaugcccau aacugaaaac agccuggaug ccgaacaagg uuuaguuaua      180

ccgccguuug uggagccaca uauucaccug gacaccacgc aaaccgccgg acaaccaaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacccaug acgacgugaa acaacgcgca uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau gucuccgacg caacgcugac ugcguugaaa      420

gcgaugcugg aagugaaaca ggaaguugcg ccguggauug aucugcaaau cgucgccuuc      480

ccgcaggaag ggauuuuguc guaucccaac ggugaagcgu ugcuggaaga ggcgcuacgc      540

uuaggggcag auguuguugg ggcgauuccg cauuuugaau uuacccguga auacggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgacguucac      660

ugugaugaga ucgaugacga gcagucgcgc uuugucgaaa ccguugcugc ccuggcguac      720

cgugaaggca ugggcgcgcg agucaccgcc agccacacca cggcaaugca cuccuauaac      780

ggggcguaua ccucacgucu guuccgcuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccgcugg ucaauauuca ucugcaagga cgauucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccaguugau gggcuacggg cagauuaacg auggccugaa uuuaaucacc     1080

caccacagug ccagaacguu gaauuugcag gauuacggca uugccgccgg aaacagcgca     1140

aaccugauua uccugccggc ugaaaaugga uuugaugcgc ugcgccguca gguuccgaua     1200

cguuauucgg uacguggcgg caaggugauu gccaguacac aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguga                            1299


<210>  5307
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5307
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccggcugccc       60

ggcaaggagg ggcuguggca gauccaccuc caggacggca agaucuccgc gaucgacgcc      120

cagagcgggg ucaugccgau cacggagaac ucccuggacg ccgagcaggg ccuggugauc      180

ccgcccuucg uggagcccca cauccaccuc gacaccaccc agaccgccgg gcagcccaac      240

uggaaccaga gcggcacgcu guucgagggc aucgagcgcu gggccgagcg gaaggcgcug      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcggac ccacguggac gucuccgacg ccacgcugac cgcgcucaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cgucgccuuc      480

ccccaggagg gcauccucag cuaccccaac ggggaggccc ugcuggagga ggcgcuccgc      540

cugggcgccg acgugguggg ggccaucccg cacuucgagu ucacccggga guacggcguc      600

gagucccugc acaagaccuu cgcccucgcc cagaaguacg accgccugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgg uucguggaga cggucgcggc ccuggccuac      720

cgcgagggca ugggggcccg ggugaccgcc ucccacacca ccgcgaugca cagcuacaac      780

ggcgccuaca cgucccgccu cuuccggcug cugaagauga gcgggaucaa cuucguggcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcggcgcggc      900

aucacccggg ugaaggagau gcuggagucc gggaucaacg ugugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc gcuggggacc gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggguacggc cagaucaacg acggccugaa ccucaucacg     1080

caccacagcg cccgcacccu gaaccugcag gacuacggga ucgcggccgg caacuccgcc     1140

aaccucauca uccugcccgc cgagaacggg uucgacgcgc ugcggcgcca gguccccauc     1200

cgguacagcg ugcgcggcgg gaaggucauc gccuccaccc agcccgccca gaccacggug     1260

uaccucgagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5308
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5308
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccgccucccc       60

ggcaaggagg gccucuggca gauccaccuc caggacggca agaucuccgc caucgacgcc      120

caguccggcg ucaugcccau caccgagaac ucccucgacg ccgagcaggg ccucgucauc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgccuac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccauc     1200

cgcuacuccg uccgcggcgg caaggucauc gccuccaccc agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5309
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5309
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc uaggcuuccc       60

ggcaaggagg ggcuguggca aauacacuug caggacggaa aaaucuccgc aauugaugcc      120

cagucuggug ucaugccuau cacugaaaau ucauuagacg cggagcaggg ccugguuauu      180

ccaccguucg uggaacccca uauccaccua gauacgaccc aaacagcugg gcagccuaac      240

uggaaucaga guggaacucu cuuugagggc auagaacggu gggccgagcg caaggcacug      300

cuuacccaug acgauguaaa acagcgagcc uggcaaacac ugaaguggca gaucgcuaac      360

gguauucagc acgugcguac ccaugucgac gugagcgaug caacuuugac agcccucaaa      420

gcuaugcugg agguuaagca ggaaguggcc ccauggaucg accugcaaau ugucgcguuc      480

ccccaggagg ggauccucuc cuacccuaau ggagaagcau uacuggagga ggcccuuaga      540

uugggcgcug augugguagg cgccauacca cacuuugagu ucaccaggga auaugggguu      600

gaaucucugc acaagacguu ugcacuagcu cagaaauacg accggcucau ugaugugcau      660

ugcgacgaga ucgaugacga acaaucgcgc uucgucgaga cuguggccgc gcuggccuau      720

agagagggaa ugggugcaag ggugaccgcu ucacacacaa cugccaugca uagcuacaac      780

ggcgcuuaua ccagucggcu uuuucgccug uugaagaugu ccgggauuaa uuucgucgcc      840

aacccccucg uuaauaucca ucugcaggga cgauuugaca cauacccuaa aagaaggggc      900

aucacccggg ugaaggaaau guuagagucu gguauuaacg uauguuucgg gcacgaugac      960

guguuugauc caugguaucc gcugggaacg gcaaauaugc uccagguccu ucacaugggc     1020

cugcacgugu gccaguugau gggcuacggg caaauaaacg acggacuaaa ucugaucacu     1080

caucacagcg cccguacacu caaccugcag gauuacggua uugcugcggg caacuccgca     1140

aaucuuauca uacugcccgc cgaaaacggg uucgacgcuu ugcgcagaca gguuccuauu     1200

agguauucag ugcggggagg caaagucauc gccaguaccc agccagcaca aacuacagug     1260

uaccucgagc agcccgaagc caucgauuau aagcgauga                            1299


<210>  5310
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5310
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc cagacugccc       60

ggcaaggagg gccuguggca gauccaccug caggacggca agaucagcgc caucgacgcc      120

cagagcggcg ugaugcccau caccgagaac agccuggacg ccgagcaggg ccuggugauc      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggccuac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccauc     1200

agauacagcg ugagaggcgg caaggugauc gccagcaccc agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5311
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5311
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucggcugccc       60

ggcaaggagg ggcuuuggca aauccaucug caggacggaa aaauuuccgc caucgaugcg      120

cagucuggcg ucaugccuau uacggaaaau agccucgacg cugagcaggg gcugguuauc      180

ccgcccuucg uggaaccuca cauccaccuu gauaccacac aaaccgccgg acagcccaac      240

uggaaucagu ccggcacacu guuugagggg auugaacgcu gggccgagag aaaggcucuc      300

cugacccaug acgaugugaa acagcgggcc uggcaaacac ugaaguggca gaucgcuaac      360

ggcauucagc acguccgcac ccauguggac guuucugaug ccacgcucac cgcgcugaaa      420

gccaugcuug aggugaagca ggaagucgcu ccuuggaucg accugcaaau uguggccuuc      480

ccccaggagg gaauccucag cuacccuaau ggcgaagcuc ugcuugagga ggcccugaga      540

cucggggcgg auguuguggg agccauuccg cacuuugagu ucacacggga auauggcguc      600

gaaucccugc acaagaccuu ugcucuggcc cagaaauacg accgccucau cgaugugcau      660

ugcgacgaga ucgaugacga acaaucuaga uucguggaga cagucgcugc ccuggccuau      720

cgggagggga ugggagcucg cguuaccgcg agccacacga cagccaugca uuccuacaac      780

ggcgcuuaua ccagcagacu uuuucggcug cucaagaugu cugggauuaa uuucguggcc      840

aacccccugg ugaauaucca ccuucaggga cgcuuugaca cauacccuaa aagacggggc      900

auuacccgcg ucaaggaaau gcuggagucc ggcaucaacg uguguuucgg gcacgaugac      960

guuuuugauc ccugguaucc ucucggaacc gccaauaugc uccaggugcu gcauaugggc     1020

cugcacgucu gccagcugau gggguacgga caaauuaacg acggccuuaa ucugaucaca     1080

caucacagcg cuagaacgcu caaccugcag gauuacggga ucgccgcggg aaacucugcu     1140

aaucuuauua uccugcccgc cgaaaacggc uucgacgccc uccggagaca ggugccgauu     1200

cgcuauuccg uucggggcgg gaaagugauc gcuagcaccc agccugccca aacaaccguc     1260

uaccuggagc agcccgaagc uauugauuau aagagauga                            1299


<210>  5312
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDU35197

<400>  5312
auguggagac uaacaguuuc aaauaacgca uuacaaacaa uaauaaaugc uagacuccca       60

ggaaaagaag gacuauggca aauccauuua caagauggaa aaaucucagc aauagaugca      120

caaaguggag uaaugccaau aacagaaaac agccuagaug cagaacaagg cuuaguaaua      180

ccaccauuug uagagccaca cauacacuua gauacgacuc aaacagcagg ccaaccaaau      240

uggaaccaaa guggaacacu auuugaagga auagaaagau gggcagaaag aaaagcauua      300

cuaacacacg augacguaaa acaaagagca uggcaaacau uaaaauggca aauagcaaac      360

ggaauccaac auguaagaac acacguagac guaucagacg cuacauuaac agcacucaaa      420

gcaaugcuag aaguaaaaca agaaguagcc ccauggauag aucuacaaau aguagcauuu      480

ccucaagaag gaauauuauc cuauccuaau ggagaagcac uacuagaaga agcauuacga      540

cuaggugcag acguaguagg agcaaucccu cauuuugaau ucacaaggga auacggcgua      600

gaaagcuuac acaaaaccuu ugcucuagca caaaaauacg acagauuaau agauguccau      660

ugcgacgaaa uagacgauga acaaucaaga uuuguagaaa caguagcagc auuagcauau      720

agagaaggua ugggugcaag aguaacagca ucacauacua cagcaaugca uagcuacaau      780

ggugcauaca caucaagacu cuuuagauua cuuaaaauga guggaauaaa uuuuguugcu      840

aacccacuag uaaacauaca ccuucaagga agauucgaua cguacccaaa aagaagaggu      900

aucacaagag uaaaagagau guuagaauca ggaauaaacg uaugcuucgg acacgacgau      960

guauuugacc caugguaucc auuaggaaca gccaauaugc uacaaguacu acauaugggu     1020

cuccauguau gucaacucau gggauacggu caaauaaacg auggacuaaa uuuaauaacu     1080

caucacucag caagaacucu aaaccuacaa gacuauggaa uagccgcagg aaauucagca     1140

aauuugauaa uacuaccagc agaaaacggu uuugacgcac uaagaagaca aguuccaaua     1200

agauauagcg ucagaggugg aaaaguaaua gcaagcacuc aaccagcuca aacaacaguu     1260

uacuuagaac aaccagaagc aauagacuau aaaagauaa                            1299


<210>  5313
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__A0A0H2V4N7

<400>  5313

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Arg Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu His Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Thr Gln Ser Gly Val Met Pro Val Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Leu Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Met Ala Ser Thr Gln Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5314
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5314
auguggaggc uaacaguguc gaauaacgcu uuacaaacaa uuauuaacgc ccgguuaccc       60

ggcaaagagg ggcuguggca gauucaucuu cacgacggaa aaaucagcgc cauugauacg      120

caaucuggug ugaugcccgu aacugaaaac agccuggaug ccgaacaagg uuuaguuuua      180

ccgccguuug uggagccgca uauucaccug gacaccacgc aaaccgccgg acaaccgaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacccaug acgaugugaa acaacgcgcc uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau gucuccgacg caacgcugac ugcguugaaa      420

gcgaugcugg aagugaaaca ggaaguugcg ccguggauug aucugcaaau cgucgccuuc      480

ccgcaggaag ggauuuuguc guaucccaac ggugaagcgu ugcuggaaga ggcguuacgc      540

uuaggggcag acguuguugg ggcgauuccg cauuuugaau uuacccguga auauggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgauguucac      660

ugugacgaga uugaugauga gcaaucacgc uuugucgaaa ccguugcugc ccuggcgcac      720

cgugaaggca ugggcgcgcg agucaccgcc agccauacua cggcaaugca cuccuauaac      780

ggggcguaua cuucgcgccu guuucguuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccguugg ucaauauuca ucugcaagga cguuucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccagcugau gggcuacggg cagauuaacg acggccugaa uuuaaucacc     1080

caccacagcg ccaggacguu gaauuugcag gauuacggca uugccgccgg aaacagcgcc     1140

aaccugauua uccugccggc ugaaaauggg uuugaugcgu ugcgccguca gguuccggua     1200

cguuauucgg uacguggcgg uaaggugaug gccagcacac aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguaa                            1299


<210>  5315
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5315
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccggcugccc       60

ggcaaggagg ggcuguggca gauccaccuc cacgacggca agaucuccgc gaucgacacg      120

cagagcgggg ucaugccggu gaccgagaac ucccuggacg ccgagcaggg ccuggugcuc      180

ccgcccuucg ucgagcccca cauccaccug gacaccaccc agacggccgg gcagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagcgcu gggccgagcg gaaggcccuc      300

cugacccacg acgacgugaa gcagcgcgcg uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcggac gcacgucgac guguccgacg ccacccucac cgcccugaag      420

gcgaugcugg aggugaagca ggaggucgcc cccuggaucg accuccagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggggaggccc ugcucgagga ggcccugcgc      540

cugggcgcgg acguggucgg ggccaucccg cacuucgagu ucacccggga guacggcgug      600

gagucccucc acaagacguu cgcccuggcc cagaaguacg accgccugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgg uucgucgaga ccguggccgc gcucgcccac      720

cgcgagggca ugggggcccg ggugaccgcc ucccacacca cggccaugca cagcuacaac      780

ggcgcguaca ccucccgccu guuccggcug cucaagauga gcgggaucaa cuucgucgcc      840

aacccccugg ugaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcggcgcggc      900

aucacccggg ugaaggagau gcuggagucc gggaucaacg ucugcuucgg ccacgacgac      960

guguucgacc ccugguaccc gcuggggacg gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgucu gccagcugau gggguacggc cagaucaacg acggccucaa ccugaucacc     1080

caccacagcg cccgcacccu gaaccuccag gacuacggga ucgccgcggg caacuccgcc     1140

aaccugauca uccugcccgc cgagaacggg uucgacgccc uccggcgcca ggugcccguc     1200

cgguacagcg ugcgcggcgg gaaggugaug gcguccaccc agcccgccca gacgaccguc     1260

uaccuggagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5316
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5316
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccgccucccc       60

ggcaaggagg gccucuggca gauccaccuc cacgacggca agaucuccgc caucgacacc      120

caguccggcg ucaugcccgu caccgagaac ucccucgacg ccgagcaggg ccucguccuc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgcccac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccguc     1200

cgcuacuccg uccgcggcgg caaggucaug gccuccaccc agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5317
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5317
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc uaggcuuccc       60

ggcaaggagg ggcuguggca aauacacuug caugacggaa aaaucuccgc aauugauacu      120

cagucuggug ucaugccugu uacggaaaau ucauuagacg ccgagcaggg ccuggugcua      180

ccaccguucg uagaacccca cauccaucuc gauaccacac agacugcggg gcaaccuaac      240

uggaaucaga guggaacccu guuugagggc auugaacggu gggcugagcg caaggcccuu      300

cugacacacg acgaugugaa acagcgagca uggcagaccu ugaaguggca aaucgccaac      360

gguauacagc auguccguac ucacguggac guuagcgaug cuacacucac cgcacugaaa      420

gccaugcugg aggugaagca ggaagucgcu ccauggaucg accuccagau uguggccuuc      480

ccccaagagg ggaucuuauc cuacccuaau ggagaagcgc ugcuugagga ggcauugaga      540

cugggcgccg auguaguugg cgcuauucca cacuuugagu ucacgaggga auauggggug      600

gaaucucuac auaagacuuu ugcccucgca cagaaauacg accggcugau cgauguccac      660

ugcgacgaga uagaugacga acagucgcgc uucguggaga ccguggcugc ccuugcgcau      720

agagagggaa ugggugccag ggucacagca ucacacacua ccgcuaugca cagcuauaac      780

ggcgccuaca caagucggcu guuucgcuug cucaagaugu ccgggauuaa uuucguugcu      840

aacccccugg ugaauaucca uuuacaagga cgauuugaca ccuauccuaa aagaaggggc      900

auuacgcggg uaaaggaaau gcuggagucu gguaucaacg uguguuucgg gcacgaugac      960

gucuuugauc caugguaccc gcucggaacu gccaauaugc uucaggugcu gcauaugggc     1020

uugcacguuu gccagcuaau gggcuauggg cagaucaacg acggacugaa ucucauuaca     1080

caucacagcg cacguacccu gaaccuucaa gauuacggua uagccgcugg caacuccgcg     1140

aaucugauca uuuugcccgc agaaaacggg uucgacgccc uccgcagaca ggugccuguc     1200

agguacucag ugcggggagg caaaguaaug gcuaguacuc agccagccca gacaaccguu     1260

uaucuggagc aacccgaagc aaucgauuac aagcgauga                            1299


<210>  5318
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5318
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc cagacugccc       60

ggcaaggagg gccuguggca gauccaccug cacgacggca agaucagcgc caucgacacc      120

cagagcggcg ugaugcccgu gaccgagaac agccuggacg ccgagcaggg ccuggugcug      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggcccac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccgug     1200

agauacagcg ugagaggcgg caaggugaug gccagcaccc agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5319
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5319
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucggcugccc       60

ggcaaggagg ggcuuuggca aauccaucug cacgacggaa aaauuuccgc caucgauacg      120

cagucuggcg ucaugccugu uaccgaaaau agccucgacg cggagcaggg gcuggugcuu      180

ccgcccuucg uggaaccuca cauucaucug gauacaaccc agacagcugg acaacccaac      240

uggaaucagu ccggcacccu cuuugagggg aucgaacgcu gggccgagag aaaggcccug      300

cugacacacg acgaugucaa acagcgggcu uggcagaccc ucaaguggca aaucgccaac      360

ggcauucagc augugcgcac gcacguugac gugucugaug cuacccugac agcccuuaaa      420

gcgaugcugg aggucaagca ggaaguggcc ccuuggaucg accuccagau uguugcuuuc      480

ccccaagagg gaauccugag cuacccuaau ggcgaagccc uucuggagga ggcucucaga      540

cugggggccg auguggucgg agcgauuccg cacuuugagu ucacccggga auauggcgug      600

gaaucccugc auaagacauu ugcccucgcu cagaaauacg accgccugau cgaugugcac      660

ugcgacgaga uugaugacga acagucuaga uucgucgaga ccguugccgc ucuugcccau      720

cgggagggga ugggagcccg cgugacggcu agccacacaa ccgcgaugca cuccuauaac      780

ggcgccuaca caagcagacu guuucggcuc cugaagaugu cugggaucaa uuucguggcu      840

aacccccuug ucaauaucca ucugcaagga cgcuuugaca ccuauccuaa aagacggggc      900

auuacccgcg ugaaggaaau gcucgagucc ggcaucaacg uuuguuucgg gcacgaugac      960

guguuugauc ccugguaccc ucugggaaca gccaauaugc ugcagguccu ccauaugggc     1020

cugcacgugu gccagcuuau gggguaugga cagauuaacg acggccugaa ucucaucacg     1080

caucacagcg ccagaacccu gaaccuucaa gauuacggga uugcugccgg aaacucugcg     1140

aaucugauca uccuccccgc ugaaaacggc uucgacgccc ugcggagaca gguuccggug     1200

cgcuacuccg uccggggcgg gaaagugaug gccagcacac agccugcuca gaccacaguc     1260

uaucuggagc aacccgaagc cauugauuac aagagauga                            1299


<210>  5320
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAN78935

<400>  5320
auguggagac uaacagucuc aaauaacgcu uuacaaacaa uaauaaaugc aagacuacca       60

ggaaaagaag gacuauggca aauacaccua cacgacggaa aaauaagcgc aauagacaca      120

caaucaggag uaaugccagu cacagaaaau agcuuagacg cugaacaagg auugguauua      180

ccaccauuug uagaaccaca cauccacuua gacacuacac aaacagccgg acaaccaaau      240

uggaaccaaa guggaacacu auucgaagga auagaaagau gggcagaaag aaaagcacua      300

uuaacccacg acgacguaaa acaaagagca uggcaaacac uaaaauggca aauagcaaau      360

gggauacaac auguacgaac acauguagau guaucagaug caacauuaac cgcauugaaa      420

gcaauguuag aaguaaaaca agaagucgca ccauggauag accuacaaau ugucgcauuc      480

ccccaagaag gaauacuauc auaccccaau ggugaagcau uacuagaaga agcacuaaga      540

cucggagcag auguaguugg agcaauacca cacuuugaau ucacuagaga auauggaguc      600

gaaagccuac acaaaacauu ugcacuagcu caaaaauaug auagauuaau agacguacac      660

ugugaugaaa uagaugauga acaaucaagg uuuguagaaa caguagcagc auuagcacau      720

agagaaggaa ugggagcaag aguaacagca agucauacaa cagcaaugca uucauacaac      780

ggagcauaca caagcagacu auuuaggcua cuaaaaaugu ccggaauaaa uuuugucgca      840

aacccacuag uaaacauaca cuuacaagga cgauucgaca cauacccaaa aagacgagga      900

aucacuagag uaaaagaaau guuagaauca ggaauaaacg uaugcuuugg acaugacgau      960

guuuuugauc ccugguaucc auuaggaaca gccaacaugu uacaaguacu acacauggga     1020

cuacaugucu gucaauuaau ggguuaugga caaauaaacg augguuuaaa ucuaauaaca     1080

caccacucag caagaacauu aaauuuacaa gacuacggaa uagcagcagg aaauucagca     1140

aacuuaauaa uacuaccugc agaaaacgga uucgacgcgu uaagacgaca aguacccgua     1200

agauacagcg uaagaggugg aaaaguaaug gcaucaacuc aacccgcaca aacaacaguu     1260

uacuuagaac aaccagaagc aauagacuau aaaagauaa                            1299


<210>  5321
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__A0A0H2YX33

<400>  5321

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Gln Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu His Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Val Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Leu Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5322
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5322
auguggaggc uaacaguguc gaauaaugcu uuacaaacaa uuauuaacgc ccaguuaccc       60

ggcaaagagg ggcuguggca gauucaucuu cacgacggaa aaaucagcgc cauugaugcg      120

caauccgggg ugaugcccgu aacugaaaac agccuggaug ccgaacaagg uuuaguuuua      180

ccgccguuug uggagccgca uauucaccug gacaccacgc aaaccgccgg acaaccgaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacucaug acgaugugaa acaacgcgca uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau gucuccgacg caacgcugac ugcguugaaa      420

gcgaugcugg aagugaaaca ggaaguugcg ccguggauug aucugcaaau cgucgccuuc      480

ccgcaggaag ggauuuuguc guaucccaac ggugaagcgu ugcuggaaga ggcgcuacgc      540

uuaggggcag auguuguugg ggcgauuccg cauuuugaau uuacccguga auacggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgacguucac      660

ugugaugaga ucgaugacga gcagucgcgc uuugucgaaa ccguugcugc ccuggcgcac      720

cgugaaggca ugggcgcgcg agucaccgcc agccauacua cggcaaugca cuccuauaac      780

ggggcguaua cuucgcgccu guuccguuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccguugg ucaauauuca ucugcaagga cguuucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccagcugau gggcuacggg cagauuaacg acggccugaa uuuaaucacc     1080

caccacagcg ccaggacguu gaauuugcag gauuacggca uugccgccgg aaacagcgcc     1140

aaccugauua uccugccggc ugaaaauggg uuugaugcgc ugcgccguca gguuccggua     1200

cguuauucgg uacguggcgg caaggugauu gccagcacac aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguaa                            1299


<210>  5323
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5323
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccagcugccc       60

ggcaaggagg ggcuguggca gauccaccuc cacgacggca agaucuccgc gaucgacgcc      120

cagagcgggg ucaugccggu gacggagaac ucccuggacg ccgagcaggg ccuggugcuc      180

ccgcccuucg ucgagcccca cauccaccug gacaccaccc agaccgccgg gcagcccaac      240

uggaaccaga gcggcacgcu guucgagggc aucgagcggu gggccgagcg caaggcgcuc      300

cugacccacg acgacgugaa gcagcgggcc uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcgcac ccacgucgac guguccgacg ccacgcucac cgcgcugaag      420

gccaugcugg aggugaagca ggaggucgcc cccuggaucg accuccagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggggaggccc ugcucgagga ggcgcugcgg      540

cugggcgccg acguggucgg ggccaucccg cacuucgagu ucacccgcga guacggcgug      600

gagucccucc acaagaccuu cgcccuggcc cagaaguacg accggcugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgc uucgucgaga cgguggcggc ccucgcccac      720

cgggagggca ugggggcccg cgugaccgcc ucccacacca ccgcgaugca cagcuacaac      780

ggcgccuaca cgucccggcu guuccgccug cucaagauga gcgggaucaa cuucgucgcc      840

aacccccugg ugaacaucca ccuccagggc cgguucgaca ccuaccccaa gcgccggggc      900

aucacccgcg ugaaggagau gcuggagucc gggaucaacg ucugcuucgg ccacgacgac      960

guguucgacc ccugguaccc gcuggggacc gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgucu gccagcugau gggguacggc cagaucaacg acggccucaa ccugaucacg     1080

caccacagcg cccggacccu gaaccuccag gacuacggga ucgcggccgg caacuccgcc     1140

aaccugauca uccugcccgc cgagaacggg uucgacgcgc uccgccgcca ggugcccguc     1200

cgguacagcg ugcggggcgg gaaggugauc gccuccaccc agcccgccca gaccacgguc     1260

uaccuggagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5324
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5324
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccagcucccc       60

ggcaaggagg gccucuggca gauccaccuc cacgacggca agaucuccgc caucgacgcc      120

caguccggcg ucaugcccgu caccgagaac ucccucgacg ccgagcaggg ccucguccuc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgcccac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccguc     1200

cgcuacuccg uccgcggcgg caaggucauc gccuccaccc agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5325
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5325
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucaacuuccc       60

ggcaaggagg ggcuguggca gauacacuug caugacggaa aaaucuccgc aauugaugcc      120

cagucuggug ucaugccugu uacugaaaau ucauuagacg cggagcaggg ccuggugcua      180

ccaccguucg uagaacccca cauccaucuc gauacgaccc aaacagcugg gcagccuaac      240

uggaaucaga guggaacucu guuugagggc auugaaaggu gggccgagcg gaaggcacuu      300

cugacccacg acgaugugaa acagcgcgcc uggcaaacau ugaaguggca gaucgcuaac      360

gguauacagc auguccgaac ccacguggac guuagcgaug caacucucac agcccugaaa      420

gcuaugcugg aggugaagca ggaagucgcc ccauggaucg accuccaaau uguggcguuc      480

ccccaggagg ggaucuuauc cuacccuaau ggagaagcac ugcuugagga ggccuugcgu      540

cugggcgcug auguaguugg cgccauucca cacuuugagu ucaccagaga auauggggug      600

gaaucucuac auaagacguu ugcacucgcu cagaaauacg acaggcugau cgauguccac      660

ugcgacgaga uagaugacga acaaucgcgg uucguggaga cuguggccgc gcuugcccau      720

cgcgagggaa ugggugcaag agucaccgcu ucacacacaa cugccaugca cagcuauaac      780

ggcgcuuaca ccaguaggcu guuucgguug cucaagaugu ccgggauuaa uuucguugcc      840

aacccccugg ugaauaucca uuuacaggga cgcuuugaca cauauccuaa acgaagaggc      900

auuaccaggg uaaaggaaau gcuggagucu gguaucaacg uguguuucgg gcacgaugac      960

gucuuugauc caugguaccc gcucggaacg gcaaauaugc uucaggugcu gcauaugggc     1020

uugcacguuu gccagcuaau gggcuauggg caaaucaacg acggacugaa ucucauuacu     1080

caucacagcg cccggacacu gaaccuucag gauuacggua uagcugcggg caacuccgca     1140

aaucugauca uuuugcccgc cgaaaacggg uucgacgcuc uccgucgcca ggugccuguc     1200

agauacucag ugaggggagg caaaguaauc gccaguaccc agccagcaca aacuacaguu     1260

uaucuggagc agcccgaagc cauagauuac aagcgguga                            1299


<210>  5326
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5326
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc ccagcugccc       60

ggcaaggagg gccuguggca gauccaccug cacgacggca agaucagcgc caucgacgcc      120

cagagcggcg ugaugcccgu gaccgagaac agccuggacg ccgagcaggg ccuggugcug      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggcccac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccgug     1200

agauacagcg ugagaggcgg caaggugauc gccagcaccc agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5327
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5327
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucaacugccc       60

ggcaaggagg ggcuuuggca gauccaccuu caugacggaa aaauuuccgc caucgaugcg      120

cagucuggcg ucaugccugu uacggaaaau agccucgacg cugagcaggg gcuggugcuu      180

ccgcccuucg uggaaccuca cauucaucug gauaccacac aaaccgccgg acagcccaac      240

uggaaucagu ccggcacacu cuuugagggg aucgaacggu gggccgagcg caaggcucug      300

cugacccacg acgaugucaa acagagagcc uggcaaacac ucaaguggca gaucgcuaac      360

ggcauucagc augugcggac ccacguugac gugucugaug ccacgcugac cgcgcuuaaa      420

gccaugcugg aggucaagca ggaaguggcu ccuuggaucg accuccaaau uguugccuuc      480

ccccaggagg gaauccugag cuacccuaau ggcgaagcuc ugcuggagga ggcccuccgc      540

cugggggcgg auguggucgg agccauuccg cacuuugagu ucacaagaga auauggcgug      600

gaaucccugc auaagaccuu ugcucucgcc cagaaauacg accggcugau cgaugugcac      660

ugcgacgaga uugaugacga acaaucucgc uucgucgaga caguugcugc ccuugcccau      720

agagagggga ugggagcucg ggugaccgcg agccacacga cagccaugca cuccuauaac      780

ggcgcuuaca ccagccgccu guuuagacuc cugaagaugu cugggaucaa uuucguggcc      840

aacccccuug ucaauaucca ucugcaggga cgguuugaca cauauccuaa acgcagaggc      900

auuacccggg ugaaggaaau gcucgagucc ggcaucaacg uuuguuucgg gcacgaugac      960

guguuugauc ccugguaccc ucugggaacc gccaauaugc ugcagguccu ccauaugggc     1020

cugcacgugu gccagcuuau gggguaugga caaauuaacg acggccugaa ucucaucaca     1080

caucacagcg cucgcacgcu gaaccuucag gauuacggga uugccgcggg aaacucugcu     1140

aaucugauca uccuccccgc cgaaaacggc uucgacgccc ugagacggca gguuccggug     1200

agauacuccg uccgcggcgg gaaagugauu gcuagcaccc agccugccca aacaaccguc     1260

uaucuggagc agcccgaagc uaucgauuac aagcgguga                            1299


<210>  5328
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABI99817

<400>  5328
auguggagau uaacaguauc aaauaaugca cuacaaacaa uaauaaaugc acaacuaccu       60

ggaaaagaag gacuauggca aauacaucua cacgauggaa aaauaucugc aauagacgca      120

caaucaggag uaaugccagu cacagaaaau agcuuagacg cugaacaagg acuaguacuc      180

cccccauucg ucgaaccaca uauacacuua gauacuacac aaacagccgg acaaccaaau      240

uggaaucaau caggaacauu auuugaagga auagaaagau gggccgaaag aaaagcauua      300

cuaacacacg augacguaaa acaaagagcu uggcaaacau uaaaauggca aauagcaaau      360

ggcauacagc augucagaac acacgucgau guaucugacg caacccuaac agcacuaaaa      420

gcuaugcuag aaguaaaaca agaaguagcu ccauggauag auuuacaaau agucgcauuu      480

ccacaagaag gaauacuauc auaucccaau ggagaagcuu uauuagaaga agcuuuaaga      540

cuaggugcag augucguugg agcaaucccu cauuucgaau ucacaagaga auacggaguu      600

gaaucacuac acaaaacauu cgcacuagcc caaaaauacg aucgauuaau agacguucau      660

ugcgaugaaa uagaugauga acaaucacga uuuguugaaa caguagcagc auuagcacau      720

agagaaggca ugggagcacg aguaacagca ucacacacaa cugcaaugca cucauacaau      780

ggagcauaua caucacgguu auucagacua cuaaaaauga gugggauaaa cuuuguagcc      840

aacccacuag uaaacauaca cuuacaagga cgauuugaca cauauccuaa aagacgagga      900

auaaccagag uaaaagaaau gcuagaauca ggaaucaaug uaugcuucgg acacgaugau      960

guauuugacc caugguaucc acuuggcaca gcaaauaugu uacaaguacu ccauauggga     1020

cuacaugucu gucaacuaau gggauacgga caaauaaacg auggauuaaa ccuaauaaca     1080

caccauucug caagaacuuu aaauuuacaa gauuauggaa uagcagcagg caauucagca     1140

aaccuuauaa uucuacccgc agaaaauggc uucgaugcau uaagaagaca aguuccagua     1200

agauauucag uaagaggagg aaaaguaauc gcaucaacac aaccugcaca aacaacagua     1260

uaccuagaac aaccagaagc aauagacuau aaacgauaa                            1299


<210>  5329
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__F4NM90

<400>  5329

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Arg Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu Gln Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5330
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5330
auguggaggu uaacaguguc gaauaacgcu uuacaaacaa uuauuaacgc ccgguuacca       60

ggcaaagagg ggcuguggca gauucaucug caggacggaa aaaucagcgc cauugaugcg      120

caauccggcg ugaugcccau aacugaaaac agccuggaug ccgaacaagg uuuaguuaua      180

ccgccguuug uggagccgca uauucaccug gacaccacgc aaaccgccgg acaaccgaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacccaug acgaugugaa acaacgcgcc uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau guuucggaug caacgcuaac ugcgcugaaa      420

gcaaugcugg aagugaagca ggaagucgcg ccguggauug aucugcaaau ugucgccuuc      480

ccucaggaag ggauuuuguc guaucccaac ggugaagcgu ugcuggaaga ggcguuacgc      540

uuaggggcag auguaguggg ggcgauuccg cauuuugaau uuacccguga auacggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgacguucac      660

ugugaugaga ucgaugacga gcagucgcgc uuugucgaaa ccguugcugc ccuggcgcac      720

cgugaaggca ugggcgcgcg agucaccgcc agccacacca cggcaaugca cuccuauaac      780

ggggcguaua ccucacgccu guuccgcuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccgcugg ucaauauuca ucugcaagga cguuucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccaguugau gggcuacggg cagauuaacg auggccugaa uuuaaucacc     1080

caccacagug ccagaacauu gaauuugcag gauuacggca uugccgccgg aaacagcgca     1140

aaccugauua uccugccggc ugaaaaugga uuugaugcgc ugcgccguca gguuccggua     1200

cguuauucgg uacguggcgg caaggugauu gccaguacac aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguaa                            1299


<210>  5331
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5331
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccggcugccc       60

ggcaaggagg ggcuguggca gauccaccuc caggacggca agaucuccgc gaucgacgcc      120

cagagcgggg ucaugccgau cacggagaac ucccuggacg ccgagcaggg ccuggugauc      180

ccgcccuucg uggagcccca cauccaccuc gacaccaccc agaccgccgg gcagcccaac      240

uggaaccaga gcggcacgcu guucgagggc aucgagcgcu gggccgagcg gaaggcgcug      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcggac ccacguggac gucuccgacg ccacgcugac cgcgcucaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cgucgccuuc      480

ccccaggagg gcauccucag cuaccccaac ggggaggccc ugcuggagga ggcgcuccgc      540

cugggcgccg acgugguggg ggccaucccg cacuucgagu ucacccggga guacggcguc      600

gagucccugc acaagaccuu cgcccucgcc cagaaguacg accgccugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgg uucguggaga cggucgcggc ccuggcccac      720

cgcgagggca ugggggcccg ggugaccgcc ucccacacca ccgcgaugca cagcuacaac      780

ggcgccuaca cgucccgccu cuuccggcug cugaagauga gcgggaucaa cuucguggcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcggcgcggc      900

aucacccggg ugaaggagau gcuggagucc gggaucaacg ugugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc gcuggggacc gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggguacggc cagaucaacg acggccugaa ccucaucacg     1080

caccacagcg cccgcacccu gaaccugcag gacuacggga ucgcggccgg caacuccgcc     1140

aaccucauca uccugcccgc cgagaacggg uucgacgcgc ugcggcgcca gguccccgug     1200

cgguacagcg uccgcggcgg gaaggugauc gccuccaccc agcccgccca gaccacggug     1260

uaccucgagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5332
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5332
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccgccucccc       60

ggcaaggagg gccucuggca gauccaccuc caggacggca agaucuccgc caucgacgcc      120

caguccggcg ucaugcccau caccgagaac ucccucgacg ccgagcaggg ccucgucauc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgcccac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccguc     1200

cgcuacuccg uccgcggcgg caaggucauc gccuccaccc agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5333
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5333
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc uaggcuuccc       60

ggcaaggagg ggcuguggca aauacacuug caggacggaa aaaucuccgc aauugaugcc      120

cagucuggug ucaugccuau cacugaaaau ucauuagacg cggagcaggg ccugguuauu      180

ccaccguucg uggaacccca uauccaccua gauacgaccc aaacagcugg gcagccuaac      240

uggaaucaga guggaacucu cuuugagggc auagaacggu gggccgagcg caaggcacug      300

cuuacccaug acgauguaaa acagcgagcc uggcaaacac ugaaguggca gaucgcuaac      360

gguauucagc acgugcguac ccaugucgac gugagcgaug caacuuugac agcccucaaa      420

gcuaugcugg agguuaagca ggaaguggcc ccauggaucg accugcaaau ugucgcguuc      480

ccccaggagg ggauccucuc cuacccuaau ggagaagcau uacuggagga ggcccuuaga      540

uugggcgcug augugguagg cgccauacca cacuuugagu ucaccaggga auaugggguu      600

gaaucucugc acaagacguu ugcacuagcu cagaaauacg accggcucau ugaugugcau      660

ugcgacgaga ucgaugacga acaaucgcgc uucgucgaga cuguggccgc gcuggcccac      720

agagagggaa ugggugcaag ggugaccgcu ucacauacaa cugccaugca cagcuauaac      780

ggcgcuuaca ccagucggcu uuuucgccug uugaagaugu ccgggauuaa uuucgucgcc      840

aacccccucg uuaauaucca ucugcaggga cgauuugaca cauauccuaa aagaaggggc      900

aucacccggg ugaaggaaau guuagagucu gguauuaacg uauguuucgg gcacgaugac      960

guguuugauc caugguaccc gcugggaacg gcaaauaugc uccagguccu ucacaugggc     1020

cugcaugugu gccaguugau gggcuauggg caaauaaacg acggacuaaa ucugaucacu     1080

caccauagcg cccguacacu caaccugcag gauuacggua uugcugcggg caacuccgca     1140

aaucuuauca uacugcccgc cgaaaacggg uucgacgcuu ugcgcagaca gguuccugug     1200

agguacucag uccggggagg caaagugauu gccaguaccc agccagcaca aacuacagua     1260

uaucucgagc agcccgaagc caucgauuac aagcgauga                            1299


<210>  5334
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5334
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc cagacugccc       60

ggcaaggagg gccuguggca gauccaccug caggacggca agaucagcgc caucgacgcc      120

cagagcggcg ugaugcccau caccgagaac agccuggacg ccgagcaggg ccuggugauc      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggcccac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccgug     1200

agauacagcg ugagaggcgg caaggugauc gccagcaccc agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5335
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5335
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucggcugccc       60

ggcaaggagg ggcuuuggca aauccaucug caggacggaa aaauuuccgc caucgaugcg      120

cagucuggcg ucaugccuau uacggaaaau agccucgacg cugagcaggg gcugguuauc      180

ccgcccuucg uggaaccuca cauccaccuu gauaccacac aaaccgccgg acagcccaac      240

uggaaucagu ccggcacacu guuugagggg auugaacgcu gggccgagag aaaggcucuc      300

cugacccaug acgaugugaa acagcgggcc uggcaaacac ugaaguggca gaucgcuaac      360

ggcauucagc acguccgcac ccauguggac guuucugaug ccacgcucac cgcgcugaaa      420

gccaugcuug aggugaagca ggaagucgcu ccuuggaucg accugcaaau uguggccuuc      480

ccccaggagg gaauccucag cuacccuaau ggcgaagcuc ugcuugagga ggcccugaga      540

cucggggcgg auguuguggg agccauuccg cacuuugagu ucacacggga auauggcguc      600

gaaucccugc acaagaccuu ugcucuggcc cagaaauacg accgccucau cgaugugcau      660

ugcgacgaga ucgaugacga acaaucuaga uucguggaga cagucgcugc ccuggcccac      720

cgggagggga ugggagcucg cguuaccgcg agccauacga cagccaugca cuccuauaac      780

ggcgcuuaca ccagcagacu uuuucggcug cucaagaugu cugggauuaa uuucguggcc      840

aacccccugg ugaauaucca ccuucaggga cgcuuugaca cauauccuaa aagacggggc      900

auuacccgcg ucaaggaaau gcuggagucc ggcaucaacg uguguuucgg gcaugaugac      960

guuuuugauc ccugguaccc ucucggaacc gccaauaugc uccaggugcu gcacaugggc     1020

cugcaugucu gccagcugau gggguaugga caaauuaacg acggccuuaa ucugaucaca     1080

caccauagcg cuagaacgcu caaccugcag gauuacggga ucgccgcggg aaacucugcu     1140

aaucuuauua uccugcccgc cgaaaacggc uucgacgccc uccggagaca ggugccgguu     1200

cgcuacuccg ugcggggcgg gaaagucauu gcuagcaccc agccugccca aacaaccgug     1260

uaucuggagc agcccgaagc uaucgauuac aagagauga                            1299


<210>  5336
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__EGJ07181

<400>  5336
auguggagau uaacuguauc aaauaacgca uuacaaacaa uaauaaaugc aagacuacca       60

ggaaaagaag guuuauggca aauacaucua caagacggaa aaauaucagc cauagacgca      120

caaagcggcg uaaugccaau aaccgaaaau aguuuagacg cagaacaagg acuaguaaua      180

ccaccuuuug uagaaccaca cauacacuua gauacuacac aaacggcagg acaaccaaau      240

uggaaucaau caggaacacu uuuugaagga auagaaagau gggcagaaag aaaagcucug      300

uuaacucacg augauguuaa acaaagagcc uggcaaacuc ucaaauggca aauagcaaac      360

ggaauacaac auguacgaac acauguugau guuagcgacg caacacuaac agcuuuaaaa      420

gccauguuag aaguaaaaca agaaguagca ccauggauag auuugcaaau aguagcauuu      480

ccacaagaag gaauauuauc auauccuaau ggagaagcac uacuagaaga agcauuaaga      540

uuaggagcag acguugucgg ugcaauacca cacuuugaau uuacacgaga auacggagua      600

gaaucacuac auaaaacauu ugcauuggca caaaaauacg acagauuaau agauguacau      660

ugcgacgaaa uugacgacga acaaucaaga uucguagaaa caguagcagc cuuagcacac      720

cgagaaggga ugggagcaag aguaacagca agccauacaa cagcaaugca cucauacaau      780

ggagccuaua caucaagacu auucagacua uuaaaaauga guggcaucaa cuuuguagca      840

aauccauuag ucaacauaca cuuacaaggu cgauuugaua cauauccuaa aagaagaggc      900

aucacaagag uaaaagaaau guuagagucu ggaauaaaug uaugcuuugg acaugacgac      960

guauuugauc ccugguaucc auuaggaacc gcuaauaugu uacaaguauu gcauaugggc     1020

uuacacguau gucaauuaau ggguuauggc caaauaaacg acggccuaaa uuuaauuacu     1080

caccauagug caagaacauu aaaccuacaa gacuauggca uagcagcagg aaacucagcu     1140

aacuuaauaa uacuaccagc agaaaacggc uuugaugcac uaagaagaca aguaccagua     1200

cgauauuccg uaagaggagg aaaaguaaua gcuagcacac aaccagcaca aacaacagua     1260

uaccuugaac aaccagaagc aauagacuau aaaagauaa                            1299


<210>  5337
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__H9UNZ4

<400>  5337

Met Pro Ile Thr Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Ile 
1               5                   10                  15      


Pro Pro Phe Val Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala 
            20                  25                  30          


Gly Gln Pro Asn Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu 
        35                  40                  45              


Arg Trp Ala Glu Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln 
    50                  55                  60                  


Arg Ala Trp Gln Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His 
65                  70                  75                  80  


Val Arg Thr His Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys 
                85                  90                  95      


Ala Met Leu Glu Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln 
            100                 105                 110         


Ile Val Ala Phe Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu 
        115                 120                 125             


Ala Leu Leu Glu Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala 
    130                 135                 140                 


Ile Pro His Phe Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His 
145                 150                 155                 160 


Lys Thr Phe Ala Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His 
                165                 170                 175     


Cys Asp Glu Ile Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala 
            180                 185                 190         


Ala Leu Ala His His Glu Gly Met Gly Ala Arg Val Thr Ala Ser His 
        195                 200                 205             


Thr Thr Ala Met His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe 
    210                 215                 220                 


Arg Leu Leu Lys Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val 
225                 230                 235                 240 


Asn Ile His Leu Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly 
                245                 250                 255     


Ile Thr Arg Val Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe 
            260                 265                 270         


Gly His Asp Asp Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn 
        275                 280                 285             


Met Leu Gln Val Leu His Met Gly Leu His Val Cys Gln Leu Met Gly 
    290                 295                 300                 


Tyr Gly Gln Ile Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala 
305                 310                 315                 320 


Arg Thr Leu Asn Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala 
                325                 330                 335     


Asn Leu Ile Ile Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg 
            340                 345                 350         


Gln Val Pro Val Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser 
        355                 360                 365             


Thr Gln Pro Ala Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile 
    370                 375                 380                 


Asp Tyr Lys Arg 
385             


<210>  5338
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5338
augcccauaa cugaaaacag ccuggaugcc gaacaagguu uaguuauacc gccguuugug       60

gagccacaua uucaccugga caccacgcaa accgccggac aaccgaacug gaaucagucc      120

ggcacgcugu uugaaggcau ugaacgcugg gccgagcgca aagcguuauu aacccaugac      180

gaugugaaac aacgcgcaug gcaaacgcug aaauggcaga uugccaacgg cauucagcau      240

gugcguaccc augucgaugu uucggaugca acgcuaacug cgcugaaagc aaugcuggaa      300

gugaagcagg aagucgcgcc guggauugau cugcaaaucg ucgccuuccc ucaggaaggg      360

auuuugucgu aucccaacgg ugaagcguug cuggaagagg cguuacgcuu aggggcagau      420

guaguggggg cgauuccgca uuuugaauuu acccgugaau acggcgugga gucgcugcau      480

aaaaccuucg cccuggcgca aaaauacgac cgucucaucg acguucacug ugaugagauc      540

gaugacgagc agucgcgcuu ugucgaaacc guugcugccc uggcgcacca ugaaggcaug      600

ggcgcgcgag ucaccgccag ccacaccacg gcaaugcacu ccuauaacgg ggcguauacc      660

ucacgccugu uccgcuugcu gaaaaugucc gguauuaacu uugucgccaa cccgcugguc      720

aauauucauc ugcaaggacg uuucgauacg uauccaaaac gucgcggcau cacgcgcguu      780

aaagagaugc uggaguccgg cauuaacguc ugcuuugguc acgaugaugu cuucgauccg      840

ugguauccgc ugggaacggc gaauaugcug caagugcugc auauggggcu gcauguuugc      900

caguugaugg gcuacgggca gauuaacgau ggccugaauu uaaucaccca ccacagcgca      960

aggacguuga auuugcagga uuacggcauu gccgccggaa acagcgccaa ccugauuauc     1020

cugccggcug aaaauggguu ugaugcgcug cgccgucagg uuccgguacg uuauucggua     1080

cguggcggca aggugauugc cagcacacaa ccggcacaaa ccaccguaua ucuggagcag     1140

ccagaagcca ucgauuacaa acguuga                                         1167


<210>  5339
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5339
augcccauca ccgagaacag ccuggacgcc gagcagggcc ucgugauccc gcccuucguc       60

gagccccaca uccaccugga caccacgcag accgccgggc agcccaacug gaaccagucc      120

ggcacccugu ucgaggggau cgagcgcugg gcggagcgga aggcccuccu gacccacgac      180

gacgugaagc agcgcgccug gcagacgcug aaguggcaga ucgccaacgg cauccagcac      240

gugcggaccc acgucgacgu gagcgacgcc acccucaccg cgcugaaggc caugcuggag      300

gugaagcagg aggucgcccc guggaucgac cuccagaucg uggccuuccc ccaggagggg      360

auccuguccu accccaacgg cgaggcgcug cucgaggagg cccugcgccu gggcgccgac      420

guggucgggg ccauccccca cuucgaguuc acgcgggagu acggcgugga gagccuccac      480

aagaccuucg cccuggcgca gaaguacgac cgccugaucg acgugcacug cgacgagauc      540

gacgacgagc agucccgguu cgucgagacc guggccgccc ucgcccacca cgaggggaug      600

ggcgcccgcg ugaccgcgag ccacacgacc gccaugcacu ccuacaacgg ggccuacacc      660

agccggcugu uccgccugcu caagaugucc ggcaucaacu ucgucgccaa cccgcuggug      720

aacauccacc uccagggccg guucgacacc uaccccaagc gccgggggau cacgcgcgug      780

aaggagaugc uggagagcgg caucaacguc ugcuucgggc acgacgacgu guucgacccc      840

ugguaccccc ugggcaccgc caacaugcuc caggugcugc acaugggccu gcacgucugc      900

cagcugaugg gguacggcca gaucaacgac gggcucaacc ugaucaccca ccacuccgcg      960

cggacccuga accuccagga cuacggcauc gccgccggga acagcgccaa ccugaucauc     1020

cugccggccg agaacggcuu cgacgcgcuc cgccgccagg ugcccgugcg guacuccguc     1080

cggggcggga aggugaucgc cagcacgcag cccgcccaga ccaccgucua ccuggagcag     1140

cccgaggcca ucgacuacaa gcgcuga                                         1167


<210>  5340
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5340
augcccauca ccgagaacuc ccucgacgcc gagcagggcc ucgucauccc ccccuucguc       60

gagccccaca uccaccucga caccacccag accgccggcc agcccaacug gaaccagucc      120

ggcacccucu ucgagggcau cgagcgcugg gccgagcgca aggcccuccu cacccacgac      180

gacgucaagc agcgcgccug gcagacccuc aaguggcaga ucgccaacgg cauccagcac      240

guccgcaccc acgucgacgu cuccgacgcc acccucaccg cccucaaggc caugcucgag      300

gucaagcagg aggucgcccc cuggaucgac cuccagaucg ucgccuuccc ccaggagggc      360

auccucuccu accccaacgg cgaggcccuc cucgaggagg cccuccgccu cggcgccgac      420

gucgucggcg ccauccccca cuucgaguuc acccgcgagu acggcgucga gucccuccac      480

aagaccuucg cccucgccca gaaguacgac cgccucaucg acguccacug cgacgagauc      540

gacgacgagc agucccgcuu cgucgagacc gucgccgccc ucgcccacca cgagggcaug      600

ggcgcccgcg ucaccgccuc ccacaccacc gccaugcacu ccuacaacgg cgccuacacc      660

ucccgccucu uccgccuccu caagaugucc ggcaucaacu ucgucgccaa cccccucguc      720

aacauccacc uccagggccg cuucgacacc uaccccaagc gccgcggcau cacccgcguc      780

aaggagaugc ucgaguccgg caucaacguc ugcuucggcc acgacgacgu cuucgacccc      840

ugguaccccc ucggcaccgc caacaugcuc cagguccucc acaugggccu ccacgucugc      900

cagcucaugg gcuacggcca gaucaacgac ggccucaacc ucaucaccca ccacuccgcc      960

cgcacccuca accuccagga cuacggcauc gccgccggca acuccgccaa ccucaucauc     1020

cuccccgccg agaacggcuu cgacgcccuc cgccgccagg uccccguccg cuacuccguc     1080

cgcggcggca aggucaucgc cuccacccag cccgcccaga ccaccgucua ccucgagcag     1140

cccgaggcca ucgacuacaa gcgcuga                                         1167


<210>  5341
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5341
augcccauca ccgagaacag ccuggacgcc gaacagggcc ucgugauucc uccauucguc       60

gagccgcaca uacaucuuga uacaacucaa acggcugggc agcccaauug gaaccagucc      120

ggaacccugu uugaagguau cgagagaugg gcagaaagga aggccuuguu aacacacgac      180

gauguuaaac agcgggcgug gcaaacucug aaguggcaga uugcuaaugg cauccagcau      240

gugcgcaccc acguagacgu gucugaugcc acacuaaccg cacucaaagc caugcuggag      300

gucaagcagg agguggcucc uuggauugac cuucaaaucg uugcauuccc acaggaaggg      360

auacugucau accccaacgg agaggccuug cucgaagagg cucugcgacu gggcgccgau      420

guggucggug cgaucccuca uuuugaguuc acucgugaau auggggugga gagucuccac      480

aaaacauuug cauuagccca gaaguacgac agacugauug auguacacug cgacgaaauc      540

gaugacgagc agagcagguu cguugaaacc guggcugccc uugcacauca cgagggaaug      600

ggcgcucggg ucacggccuc ccauacuacc gcgaugcacu cuuauaaugg cgccuacaca      660

ucgcgcuugu uuagacugcu aaagauguca gggauuaacu ucguggcaaa uccacucgug      720

aacauccauc ugcaaggaag guuugauacu uaucccaaac ggcgcgguau aacccgaguc      780

aaggagaugc uugaaagcgg cauuaauguu uguuucgggc acgacgacgu guuugauccu      840

ugguacccac ugggaacagc uaacauguug cagguacucc acaugggccu gcaugugugc      900

caguuaaugg guuaugggca aaucaaugac ggacugaacc ucauuaccca ccauagugcc      960

agaacgcuua aucugcagga uuacggcauc gcugccggca acuccgcaaa uuugaucauu     1020

cuaccggccg agaacggguu cgacgcucug aggcggcagg uccccgugcg uuacucuguu     1080

cgcggaggua aagugauagc gagcacucag ccugcacaaa caaccgucua ucucgaacag     1140

ccagaggcca ucgauuacaa gagauga                                         1167


<210>  5342
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5342
augcccauca ccgagaacag ccuggacgcc gagcagggcc uggugauccc ccccuucgug       60

gagccccaca uccaccugga caccacccag accgccggcc agcccaacug gaaccagagc      120

ggcacccugu ucgagggcau cgagagaugg gccgagagaa aggcccugcu gacccacgac      180

gacgugaagc agagagccug gcagacccug aaguggcaga ucgccaacgg cauccagcac      240

gugagaaccc acguggacgu gagcgacgcc acccugaccg cccugaaggc caugcuggag      300

gugaagcagg agguggcccc cuggaucgac cugcagaucg uggccuuccc ccaggagggc      360

auccugagcu accccaacgg cgaggcccug cuggaggagg cccugagacu gggcgccgac      420

guggugggcg ccauccccca cuucgaguuc accagagagu acggcgugga gagccugcac      480

aagaccuucg cccuggccca gaaguacgac agacugaucg acgugcacug cgacgagauc      540

gacgacgagc agagcagauu cguggagacc guggccgccc uggcccacca cgagggcaug      600

ggcgccagag ugaccgccag ccacaccacc gccaugcaca gcuacaacgg cgccuacacc      660

agcagacugu ucagacugcu gaagaugagc ggcaucaacu ucguggccaa cccccuggug      720

aacauccacc ugcagggcag auucgacacc uaccccaaga gaagaggcau caccagagug      780

aaggagaugc uggagagcgg caucaacgug ugcuucggcc acgacgacgu guucgacccc      840

ugguaccccc ugggcaccgc caacaugcug caggugcugc acaugggccu gcacgugugc      900

cagcugaugg gcuacggcca gaucaacgac ggccugaacc ugaucaccca ccacagcgcc      960

agaacccuga accugcagga cuacggcauc gccgccggca acagcgccaa ccugaucauc     1020

cugcccgccg agaacggcuu cgacgcccug agaagacagg ugcccgugag auacagcgug     1080

agaggcggca aggugaucgc cagcacccag cccgcccaga ccaccgugua ccuggagcag     1140

cccgaggcca ucgacuacaa gagauga                                         1167


<210>  5343
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5343
augcccauca ccgagaacag ccuggacgcc gaacagggcc ucgugauucc uccguucguc       60

gagccccaca uccaucugga uacaacgcaa accgcugggc agccuaauug gaaccagucc      120

ggaacacuuu uugaaggcau ugagagaugg gccgaacgga aggcgcugcu cacccacgac      180

gauguuaaac agcgcgcuug gcaaacacug aaguggcaga ucgccaaugg gauucagcau      240

gugagaaccc acguggacgu cucugaugcc acacuuaccg cucugaaagc caugcucgag      300

gugaagcagg agguugcucc cuggaucgac cugcaaaucg uggccuuccc ucaggaaggc      360

auucugagcu accccaacgg agaggcgcuc cuggaagagg cccuucggcu gggggcugau      420

gucgugggag ccaucccuca uuuugaguuc acgcgcgaau auggcguuga gucccuccac      480

aaaaccuuug cucuggccca gaaguacgac agacuuauug augugcacug cgacgaaauc      540

gaugacgagc agucucgguu cgucgaaaca guggcggccc uggcucauca cgagggcaug      600

ggggcccgcg ugaccgcuag ccauacaacc gccaugcacu ccuauaaugg agccuacacg      660

ucuagacucu uucggcugcu gaagaugagc ggcauuaacu ucgucgcuaa uccgcucguu      720

aacauccauc ugcaagggcg cuuugauaca uaucccaaaa gacggggaau uacccgcgug      780

aaggagaugc uugaauccgg caucaaugug uguuucgggc acgacgacgu cuuugauccu      840

ugguaccccc ugggaacagc gaacaugcuc caggugcugc acaugggccu ucauguuugc      900

cagcugaugg gcuaugggca aaucaaugac ggacucaacc ugauuaccca ccauagcgcc      960

agaacccuga aucuccagga uuacggcauc gcugccggga acucugccaa ucugauuauc     1020

cuuccugcug agaacggauu cgacgcccug cggcgccagg ugcccgucag auacuccgug     1080

cggggcggga aaguuauugc gagcacacag ccggcucaaa cgaccgugua ucucgaacag     1140

ccugaggcca ucgauuacaa gagauga                                         1167


<210>  5344
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__AFG39237

<400>  5344
augccaauaa cagaaaauuc auuggaugca gaacaaggau uaguaauucc accauucgua       60

gaaccacaca uacauuuaga cacaacacaa acagcaggac aaccaaauug gaaucaauca      120

ggaacuuuau ucgaaggaau cgaacgcugg gcagaaagaa aagcacuauu aacacacgac      180

gauguuaaac aaagagccug gcaaacucua aaauggcaaa uagcaaacgg aauacaacac      240

guaagaacac acguagacgu aucagacgca acuuuaacag cacuaaaagc aauguuagaa      300

guaaaacaag aaguagcacc guggauagac cuacaaauag uagcauuucc acaagaagga      360

aucuuaagcu auccaaacgg agaagcauua cuagaagaag cacuaagacu cggagcagau      420

guaguaggag caauaccaca cuuugaauuc acaagagaau auggaguaga aucuuuacau      480

aaaacauuug cacuagcaca aaaauacgac agacucaucg auguccacug cgaugaaaua      540

gacgaugaac aaaguagauu ugucgaaaca guugcagcac uagcacauca cgaaggaaug      600

ggagcaagag uaacagcauc acauacaaca gcaaugcacu cauacaaugg cgcauacaca      660

agucgacuau uuagauuauu aaaaauguca ggaauaaacu uuguagcuaa cccacuagua      720

aauauccacc uccaaggaag auucgacaca uacccaaaaa gacgaggaau cacaagagua      780

aaagaaaugu uagaaagugg aauaaacgua ugcuuuggac augacgaugu auucgaucca      840

ugguauccuc uuggaacagc caauauguua caaguacuac acaugggacu acauguaugc      900

caauuaaugg gauacggaca aauaaacgac ggucuuaacu uaauaacaca ucacagugca      960

agaacauuaa acuuacaaga cuauggcaua gcagccggaa auucagcaaa ucuaauaauu     1020

cuaccagcag aaaacggcuu ugaugcauua agaagacaag uuccaguaag auacucagua     1080

agaggaggua aaguaaucgc aucaacacaa ccagcccaaa caacaguaua uuuagaacaa     1140

ccagaagcaa uagacuacaa aagauaa                                         1167


<210>  5345
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__Q1RFJ5

<400>  5345

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Gln Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu His Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Val Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Leu Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5346
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5346
auguggaggc uaacaguguc gaauaaugcu uuacaaacaa uuauuaacgc ccaguuaccc       60

ggcaaagagg ggcuguggca gauucaucuu cacgacggaa aaaucagcgc cauugaugcg      120

caauccgggg ugaugcccgu aacugaaaac agccuggaug ccgaacaagg uuuaguuuua      180

ccgccguuug uggagccgca uauucaccug gacaccacgc aaaccgccgg acaaccgaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacucaug acgaugugaa acaacgcgca uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau gucuccgacg caacgcugac ugcguugaaa      420

gcgaugcugg aagugaaaca ggaaguugcg ccguggauug aucugcaaau cgucgccuuc      480

ccgcaggaag ggauuuuguc guaucccaac ggugaagcgc ugcuggaaga ggcgcuacgc      540

uuaggggcag auguuguugg ggcgauuccg cauuuugaau uuacccguga auacggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgacguucac      660

ugugaugaga ucgaugacga gcagucgcgc uuugucgaaa ccguugcugc ccuggcgcac      720

cgugaaggca ugggcgcgcg agucaccgcc agccauacua cggcaaugca cuccuauaac      780

ggggcguaua cuucgcgccu guuccguuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccguugg ucaauauuca ucugcaagga cguuucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccagcugau gggcuacggg cagauuaacg acggccugaa uuuaaucacc     1080

caccacagcg ccaggacguu gaauuugcag gauuacggca uugccgccgg aaacagcgcc     1140

aaccugauua uccugccggc ugaaaauggg uuugaugcgc ugcgccguca gguuccggua     1200

cguuauucgg uacguggcgg caaggugauu gccagcacac aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguaa                            1299


<210>  5347
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5347
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccagcugccc       60

ggcaaggagg ggcuguggca gauccaccuc cacgacggca agaucuccgc gaucgacgcc      120

cagagcgggg ucaugccggu gacggagaac ucccuggacg ccgagcaggg ccuggugcuc      180

ccgcccuucg ucgagcccca cauccaccug gacaccaccc agaccgccgg gcagcccaac      240

uggaaccaga gcggcacgcu guucgagggc aucgagcggu gggccgagcg caaggcgcuc      300

cugacccacg acgacgugaa gcagcgggcc uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcgcac ccacgucgac guguccgacg ccacgcucac cgcgcugaag      420

gccaugcugg aggugaagca ggaggucgcc cccuggaucg accuccagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggggaggccc ugcucgagga ggcgcugcgg      540

cugggcgccg acguggucgg ggccaucccg cacuucgagu ucacccgcga guacggcgug      600

gagucccucc acaagaccuu cgcccuggcc cagaaguacg accggcugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgc uucgucgaga cgguggcggc ccucgcccac      720

cgggagggca ugggggcccg cgugaccgcc ucccacacca ccgcgaugca cagcuacaac      780

ggcgccuaca cgucccggcu guuccgccug cucaagauga gcgggaucaa cuucgucgcc      840

aacccccugg ugaacaucca ccuccagggc cgguucgaca ccuaccccaa gcgccggggc      900

aucacccgcg ugaaggagau gcuggagucc gggaucaacg ucugcuucgg ccacgacgac      960

guguucgacc ccugguaccc gcuggggacc gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgucu gccagcugau gggguacggc cagaucaacg acggccucaa ccugaucacg     1080

caccacagcg cccggacccu gaaccuccag gacuacggga ucgcggccgg caacuccgcc     1140

aaccugauca uccugcccgc cgagaacggg uucgacgcgc uccgccgcca ggugcccguc     1200

cgguacagcg ugcggggcgg gaaggugauc gccuccaccc agcccgccca gaccacgguc     1260

uaccuggagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5348
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5348
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccagcucccc       60

ggcaaggagg gccucuggca gauccaccuc cacgacggca agaucuccgc caucgacgcc      120

caguccggcg ucaugcccgu caccgagaac ucccucgacg ccgagcaggg ccucguccuc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgcccac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccguc     1200

cgcuacuccg uccgcggcgg caaggucauc gccuccaccc agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5349
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5349
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucaacuuccc       60

ggcaaggagg ggcuguggca gauacacuug caugacggaa aaaucuccgc aauugaugcc      120

cagucuggug ucaugccugu uacugaaaau ucauuagacg cggagcaggg ccuggugcua      180

ccaccguucg uagaacccca cauccaucuc gauacgaccc aaacagcugg gcagccuaac      240

uggaaucaga guggaacucu guuugagggc auugaaaggu gggccgagcg gaaggcacuu      300

cugacccacg acgaugugaa acagcgcgcc uggcaaacau ugaaguggca gaucgcuaac      360

gguauacagc auguccgaac ccacguggac guuagcgaug caacucucac agcccugaaa      420

gcuaugcugg aggugaagca ggaagucgcc ccauggaucg accuccaaau uguggcguuc      480

ccccaggagg ggaucuuauc cuacccuaau ggagaagcac ugcuugagga ggccuugcgu      540

cugggcgcug auguaguugg cgccauucca cacuuugagu ucaccagaga auauggggug      600

gaaucucuac auaagacguu ugcacucgcu cagaaauacg acaggcugau cgauguccac      660

ugcgacgaga uagaugacga acaaucgcgg uucguggaga cuguggccgc gcuugcccau      720

cgcgagggaa ugggugcaag agucaccgcu ucacacacaa cugccaugca cagcuauaac      780

ggcgcuuaca ccaguaggcu guuucgguug cucaagaugu ccgggauuaa uuucguugcc      840

aacccccugg ugaauaucca uuuacaggga cgcuuugaca cauauccuaa acgaagaggc      900

auuaccaggg uaaaggaaau gcuggagucu gguaucaacg uguguuucgg gcacgaugac      960

gucuuugauc caugguaccc gcucggaacg gcaaauaugc uucaggugcu gcauaugggc     1020

uugcacguuu gccagcuaau gggcuauggg caaaucaacg acggacugaa ucucauuacu     1080

caucacagcg cccggacacu gaaccuucag gauuacggua uagcugcggg caacuccgca     1140

aaucugauca uuuugcccgc cgaaaacggg uucgacgcuc uccgucgcca ggugccuguc     1200

agauacucag ugaggggagg caaaguaauc gccaguaccc agccagcaca aacuacaguu     1260

uaucuggagc agcccgaagc cauagauuac aagcgguga                            1299


<210>  5350
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5350
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc ccagcugccc       60

ggcaaggagg gccuguggca gauccaccug cacgacggca agaucagcgc caucgacgcc      120

cagagcggcg ugaugcccgu gaccgagaac agccuggacg ccgagcaggg ccuggugcug      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggcccac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccgug     1200

agauacagcg ugagaggcgg caaggugauc gccagcaccc agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5351
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5351
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucaacugccc       60

ggcaaggagg ggcuuuggca gauccaccuu caugacggaa aaauuuccgc caucgaugcg      120

cagucuggcg ucaugccugu uacggaaaau agccucgacg cugagcaggg gcuggugcuu      180

ccgcccuucg uggaaccuca cauucaucug gauaccacac aaaccgccgg acagcccaac      240

uggaaucagu ccggcacacu cuuugagggg aucgaacggu gggccgagcg caaggcucug      300

cugacccacg acgaugucaa acagagagcc uggcaaacac ucaaguggca gaucgcuaac      360

ggcauucagc augugcggac ccacguugac gugucugaug ccacgcugac cgcgcuuaaa      420

gccaugcugg aggucaagca ggaaguggcu ccuuggaucg accuccaaau uguugccuuc      480

ccccaggagg gaauccugag cuacccuaau ggcgaagcuc ugcuggagga ggcccuccgc      540

cugggggcgg auguggucgg agccauuccg cacuuugagu ucacaagaga auauggcgug      600

gaaucccugc auaagaccuu ugcucucgcc cagaaauacg accggcugau cgaugugcac      660

ugcgacgaga uugaugacga acaaucucgc uucgucgaga caguugcugc ccuugcccau      720

agagagggga ugggagcucg ggugaccgcg agccacacga cagccaugca cuccuauaac      780

ggcgcuuaca ccagccgccu guuuagacuc cugaagaugu cugggaucaa uuucguggcc      840

aacccccuug ucaauaucca ucugcaggga cgguuugaca cauauccuaa acgcagaggc      900

auuacccggg ugaaggaaau gcucgagucc ggcaucaacg uuuguuucgg gcacgaugac      960

guguuugauc ccugguaccc ucugggaacc gccaauaugc ugcagguccu ccauaugggc     1020

cugcacgugu gccagcuuau gggguaugga caaauuaacg acggccugaa ucucaucaca     1080

caucacagcg cucgcacgcu gaaccuucag gauuacggga uugccgcggg aaacucugcu     1140

aaucugauca uccuccccgc cgaaaacggc uucgacgccc ugagacggca gguuccggug     1200

agauacuccg uccgcggcgg gaaagugauu gcuagcaccc agccugccca aacaaccguc     1260

uaucuggagc agcccgaagc uaucgauuac aagcgguga                            1299


<210>  5352
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__ABE05869

<400>  5352
auguggagau uaacaguaag caauaacgca cuacaaacaa uaauaaaugc acaacuccca       60

ggaaaagaag gauuauggca aauucacuua caugacggaa aaauaucagc aauagaugca      120

caaucaggag ucaugccagu aacagaaaau agccuugacg cagaacaagg gcuaguccua      180

cccccauucg uagaaccaca cauacauuua gauacuacac aaacagcagg ucaaccaaau      240

uggaaucaau caggaacacu auuugaagga auagaaagau gggcagaaag aaaagcauua      300

cuaacacaug augacguaaa acaaagagca uggcaaacac ucaaauggca aauagccaau      360

ggaauacaac auguaagaac ucacgucgac gucagugacg cuacauuaac ugcacuuaaa      420

gcaaugcugg aaguaaaaca agaaguagca ccauggaucg aucuacaaau aguagcauuu      480

ccacaagaag gaauauuauc uuacccuaau ggagaagcuu uacuagaaga agcauuaaga      540

cuaggagcug acguaguagg agcaauacca cacuuugaau uuacaagaga auauggcgua      600

gaaucuuuac auaagacauu cgcacuagca caaaaauacg auaggcuaau agauguacau      660

ugcgacgaaa uagaugauga acaaagcaga uucguagaaa caguagcagc acuugcacac      720

agagaaggaa ugggagcaag aguuacagca ucacacacaa cagcaaugca uaguuacaau      780

ggagcauaca caagcagauu auuuagacuc cuaaaaauga guggaauaaa cuuuguagca      840

aauccacuag uaaauauaca uuuacaagga cgauuugaua cuuauccaaa aagacgagga      900

auaacaagag uaaaagaaau gcuagaaucu ggcauaaaug ugugcuucgg ccaugaugau      960

gucuuugauc caugguaucc acuagguaca gcaaauaugc uacaaguucu acacauggga     1020

uuacauguau gccaacuuau gggauaugga caaauaaacg acggccuuaa ccuaauaaca     1080

caccacucag ccagaacauu aaauuuacaa gacuacggaa uagcagcagg aaauucagca     1140

aaucucauaa uacugccagc agaaaacgga uuugaugccu uaagaagaca aguaccuguu     1200

agauacagcg uuagaggagg uaagguaaua gcaucaacac aaccagcaca aacaacagua     1260

uaccuagaac aaccagaagc uauagacuac aaaagauaa                            1299


<210>  5353
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__Q2VP09

<400>  5353

Met Lys Gln Arg Ile Thr Val Thr Val Asp Ser Asp Ser Tyr Gln Leu 
1               5                   10                  15      


Leu Lys Ala Tyr Asp Val Asn Ile Ser Gly Leu Val Ser Thr Thr Met 
            20                  25                  30          


Gln Asn Glu Ala Arg Arg Leu Arg Ala Glu Arg Trp Lys Ala Glu Asn 
        35                  40                  45              


Gln Glu Gly Met Ala Glu Val Ala Arg Phe Ile Glu Met Asn Gly Ser 
    50                  55                  60                  


Phe Ala Asp Glu Asn Arg Asp Trp 
65                  70          


<210>  5354
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5354
augaagcagc guauuacagu gacaguugac agcgacagcu aucaguugcu caaggcauau       60

gaugucaaua ucuccggucu gguaagcaca accaugcaga augaagcccg ucgucugcgu      120

gccgaacgcu ggaaagcgga aaaucaggaa gggauggcug aggucgcccg guuuauugaa      180

augaacggcu cuuuugcuga cgagaacagg gacugguga                             219


<210>  5355
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5355
augaagcagc gcaucaccgu gaccgucgac agcgacuccu accagcugcu caaggccuac       60

gacgugaaca ucagcggccu gguguccacg accaugcaga acgaggcccg gcgccugcgg      120

gcggagcgcu ggaaggccga gaaccaggag gggauggccg aggucgcccg guucaucgag      180

augaacggca gcuucgccga cgagaaccgc gacugguga                             219


<210>  5356
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5356
augaagcagc gcaucaccgu caccgucgac uccgacuccu accagcuccu caaggccuac       60

gacgucaaca ucuccggccu cgucuccacc accaugcaga acgaggcccg ccgccuccgc      120

gccgagcgcu ggaaggccga gaaccaggag ggcauggccg aggucgcccg cuucaucgag      180

augaacggcu ccuucgccga cgagaaccgc gacugguga                             219


<210>  5357
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5357
augaagcaga gaaucaccgu gacagucgac agcgauuccu accaacugcu caaagccuau       60

gacguuaaca uuucuggccu ugugucaacu acgaugcaga augaggcuag gcggcugcgc      120

gcagaacgau ggaaggccga gaaccaggaa gggauggcgg agguagcucg uuucauagaa      180

augaauggaa guuuugccga ugagaacaga gacugguga                             219


<210>  5358
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5358
augaagcaga gaaucaccgu gaccguggac agcgacagcu accagcugcu gaaggccuac       60

gacgugaaca ucagcggccu ggugagcacc accaugcaga acgaggccag aagacugaga      120

gccgagagau ggaaggccga gaaccaggag ggcauggccg agguggccag auucaucgag      180

augaacggca gcuucgccga cgagaacaga gacugguga                             219


<210>  5359
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5359
augaagcaga gaaucaccgu gacagucgac agcgauuccu accaacugcu caaagccuau       60

gacguuaaca uuucuggccu ggugagcacg accaugcaga augaggcucg gcgccuuaga      120

gccgaacggu ggaaggcgga gaaccaggaa gggauggcug agguggcccg cuucaucgaa      180

augaauggau ccuuugccga ugagaacaga gacugguga                             219


<210>  5360
<211>  219
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__ACQ41973

<400>  5360
augaaacaaa gaauaacagu aacaguagau agcgacagcu aucaauuacu aaaagcauau       60

gacguaaaca uaagcggacu aguaagcaca acaaugcaaa augaagcaag aagacuaaga      120

gcagaaagau ggaaagcaga aaaucaagaa ggaauggcag aaguagcaag auuuauagaa      180

augaauggau cauucgcaga cgaaaacaga gacugguaa                             219


<210>  5361
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__Q53ZC8

<400>  5361

Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425         


<210>  5362
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5362
augucgaaua acgcuuuaca aacaauuauu aacgcccggu uaccaggcga agaggggcug       60

uggcagauuc aucugcagga cggaaaaauc agcgccauug augcgcaauc cggcgugaug      120

cccauaacug aaaacagccu ggaugccgaa caagguuuag uuauaccgcc guuuguggag      180

ccacauauuc accuggacac cacgcaaacc gccggacaac cgaacuggaa ucaguccggc      240

acgcuguuug aaggcauuga acgcugggcc gagcgcaaag cguuauuaac ccaugacgau      300

gugaaacaac gcgcauggca aacgcugaaa uggcagauug ccaacggcau ucagcaugug      360

cguacccaug ucgauguuuc ggaugcaacg cuaacugcgc ugaaagcaau gcuggaagug      420

aagcaggaag ucgcgccgug gauugaucug caaaucgucg ccuucccuca ggaagggauu      480

uugucguauc ccaacgguga agcguugcug gaagaggcgu uacgcuuagg ggcagaugua      540

gugggggcga uuccgcauuu ugaauuuacc cgugaauacg gcguggaguc gcugcauaaa      600

accuucgccc uggcgcaaaa auacgaccgu cucaucgacg uucacuguga ugagaucgau      660

gacgagcagu cgcgcuuugu cgaaaccguu gcugcccugg cgcaccauga aggcaugggc      720

gcgcgaguca ccgccagcca caccacggca augcacuccu auaacggggc guauaccuca      780

cgccuguucc gcuugcugaa aauguccggu auuaacuuug ucgccaaccc gcuggucaau      840

auucaucugc aaggacguuu cgauacguau ccaaaacguc gcggcaucac gcgcguuaaa      900

gagaugcugg aguccggcau uaacgucugc uuuggucacg augaugucuu cgauccgugg      960

uauccgcugg gaacggcgaa uaugcugcaa gugcugcaua uggggcugca uguuugccag     1020

uugaugggcu acgggcagau uaacgauggc cugaauuuaa ucacccacca cagcgcaagg     1080

acguugaauu ugcaggauua cggcauugcc gccggaaaca gcgccaaccu gauuauccug     1140

ccggcugaaa auggguuuga ugcgcugcgc cgucagguuc cgguacguua uucgguacgu     1200

ggcggcaagg ugauugccag cacacaaccg gcacaaacca ccguauaucu ggagcagcca     1260

gaagccaucg auuacaaacg uuga                                            1284


<210>  5363
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5363
augagcaaca acgcccugca gaccaucauc aacgcccgcc uccccggcga ggaggggcug       60

uggcagaucc accuccagga cggcaagauc uccgcgaucg acgcccagag cggggugaug      120

ccgaucaccg agaacucccu ggacgccgag cagggccugg ucaucccgcc cuucguggag      180

ccccacaucc accuggacac gacccagacc gccgggcagc ccaacuggaa ccagagcggc      240

acccucuucg agggcaucga gcggugggcc gagcgcaagg cgcugcugac gcacgacgac      300

gugaagcagc gggccuggca gacccucaag uggcagaucg ccaacgggau ccagcacguc      360

cgcacccacg uggacguguc cgacgccacc cugacggcgc ugaaggccau gcucgagguc      420

aagcaggagg uggcccccug gaucgaccug cagaucgugg ccuuccccca ggagggcauc      480

cugagcuacc ccaacgggga ggcccuccug gaggaggcgc ugcggcucgg cgccgacguc      540

gugggggcca ucccgcacuu cgaguucacc cgcgaguacg gcguggaguc ccugcacaag      600

accuucgccc uggcccagaa guacgaccgg cucaucgacg uccacugcga cgagaucgac      660

gacgagcaga gccgcuucgu ggagaccgug gcggcccugg cccaccacga gggcaugggg      720

gcccggguca cggccuccca caccaccgcg augcacagcu acaacggcgc cuacaccucc      780

cgccuguucc ggcuccugaa gaugagcggg aucaacuucg uggccaaccc ccuggugaac      840

auccaccucc agggccgcuu cgacacguac cccaagcggc gcggcaucac ccgggucaag      900

gagaugcugg aguccgggau caacgugugc uucggccacg acgacguguu cgaccccugg      960

uacccgcugg ggaccgccaa caugcuccag guccugcaca ugggccugca cgugugccag     1020

cucauggggu acggccagau caacgacggc cugaaccuga ucacccacca cagcgcccgc     1080

acgcucaacc ugcaggacua cgggaucgcg gccggcaacu ccgccaaccu gaucauccuc     1140

cccgccgaga acggguucga cgcgcugcgg cgccaggugc ccguccggua cagcgugcgc     1200

ggcgggaagg ucaucgccuc cacccagccc gcccagacca ccguguaccu ggagcagccg     1260

gaggccaucg acuacaagcg guga                                            1284


<210>  5364
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5364
auguccaaca acgcccucca gaccaucauc aacgcccgcc uccccggcga ggagggccuc       60

uggcagaucc accuccagga cggcaagauc uccgccaucg acgcccaguc cggcgucaug      120

cccaucaccg agaacucccu cgacgccgag cagggccucg ucaucccccc cuucgucgag      180

ccccacaucc accucgacac cacccagacc gccggccagc ccaacuggaa ccaguccggc      240

acccucuucg agggcaucga gcgcugggcc gagcgcaagg cccuccucac ccacgacgac      300

gucaagcagc gcgccuggca gacccucaag uggcagaucg ccaacggcau ccagcacguc      360

cgcacccacg ucgacgucuc cgacgccacc cucaccgccc ucaaggccau gcucgagguc      420

aagcaggagg ucgcccccug gaucgaccuc cagaucgucg ccuuccccca ggagggcauc      480

cucuccuacc ccaacggcga ggcccuccuc gaggaggccc uccgccucgg cgccgacguc      540

gucggcgcca ucccccacuu cgaguucacc cgcgaguacg gcgucgaguc ccuccacaag      600

accuucgccc ucgcccagaa guacgaccgc cucaucgacg uccacugcga cgagaucgac      660

gacgagcagu cccgcuucgu cgagaccguc gccgcccucg cccaccacga gggcaugggc      720

gcccgcguca ccgccuccca caccaccgcc augcacuccu acaacggcgc cuacaccucc      780

cgccucuucc gccuccucaa gauguccggc aucaacuucg ucgccaaccc ccucgucaac      840

auccaccucc agggccgcuu cgacaccuac cccaagcgcc gcggcaucac ccgcgucaag      900

gagaugcucg aguccggcau caacgucugc uucggccacg acgacgucuu cgaccccugg      960

uacccccucg gcaccgccaa caugcuccag guccuccaca ugggccucca cgucugccag     1020

cucaugggcu acggccagau caacgacggc cucaaccuca ucacccacca cuccgcccgc     1080

acccucaacc uccaggacua cggcaucgcc gccggcaacu ccgccaaccu caucauccuc     1140

cccgccgaga acggcuucga cgcccuccgc cgccaggucc ccguccgcua cuccguccgc     1200

ggcggcaagg ucaucgccuc cacccagccc gcccagacca ccgucuaccu cgagcagccc     1260

gaggccaucg acuacaagcg cuga                                            1284


<210>  5365
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5365
augagcaaca augcccugca gaccaucauu aacgcuagac uccccggcga ggaagggcuu       60

uggcaaauac aucugcagga cggaaagauc uccgcaauug augcccaguc uggugugaug      120

ccuaucacag agaauaguuu ggacgcggaa cagggcuuag ucauuccacc guucguugag      180

ccccacaucc accuggauac uacgcaaacc gcugggcagc cuaacuggaa ucagagugga      240

acacuauuug aaggcauaga gaggugggcc gagcggaaag cacuccugac ucaugacgau      300

gugaagcagc gcgccuggca aacccuuaaa uggcagaucg cuaacgguau ucagcacgua      360

cgaacacaug uggacgucag cgaugcaacc cugacugccu ugaaggcuau gcucgaagug      420

aaacaggagg uugccccaug gaucgaccug caaauugugg cguuccccca ggaagggauc      480

cuguccuacc cuaauggaga ggcacucuua gaggaagccc ugcgucuugg cgcugauguc      540

gugggcgcca uaccacacuu ugaguucaca agagaauaug ggguagaguc uuugcacaag      600

accuuugcac uggcucagaa guacgacagg cuaauugaug uucauugcga cgaaaucgau      660

gacgagcaau cgcgguucgu ggagacgguc gccgcgcucg cccaccauga aggaaugggu      720

gcacgcguga cugcuucaca caccacagcc augcacagcu auaacggcgc uuacacuuca      780

agacuguuua ggcuucugaa aauguccggg auuaauuucg uggccaaccc cuuggucaau      840

auccaucucc agggacgguu ugacaccuau ccuaagcgcc gaggcaucac aagaguuaaa      900

gagaugcugg aaucugguau uaacgugugu uucgggcacg augacguauu ugauccaugg      960

uacccguuag gaaccgcaaa uaugcuccag gugcugcaua ugggccuuca cgucugccag     1020

cugaugggcu augggcaaau aaacgacgga uugaaucuaa ucacgcauca cagcgccagg     1080

acucugaacc uccaggauua cgguauugcu gcgggcaacu ccgcaaaucu gaucauacuu     1140

cccgccgaga acggguucga cgcucugcgg cgucaggugc cuguucgcua cucagugaga     1200

ggaggcaagg ucauugccag uacacagcca gcacaaacca cuguguauuu ggaacagccc     1260

gaggccaucg auuacaaaag guga                                            1284


<210>  5366
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5366
augagcaaca acgcccugca gaccaucauc aacgccagac ugcccggcga ggagggccug       60

uggcagaucc accugcagga cggcaagauc agcgccaucg acgcccagag cggcgugaug      120

cccaucaccg agaacagccu ggacgccgag cagggccugg ugaucccccc cuucguggag      180

ccccacaucc accuggacac cacccagacc gccggccagc ccaacuggaa ccagagcggc      240

acccuguucg agggcaucga gagaugggcc gagagaaagg cccugcugac ccacgacgac      300

gugaagcaga gagccuggca gacccugaag uggcagaucg ccaacggcau ccagcacgug      360

agaacccacg uggacgugag cgacgccacc cugaccgccc ugaaggccau gcuggaggug      420

aagcaggagg uggcccccug gaucgaccug cagaucgugg ccuuccccca ggagggcauc      480

cugagcuacc ccaacggcga ggcccugcug gaggaggccc ugagacuggg cgccgacgug      540

gugggcgcca ucccccacuu cgaguucacc agagaguacg gcguggagag ccugcacaag      600

accuucgccc uggcccagaa guacgacaga cugaucgacg ugcacugcga cgagaucgac      660

gacgagcaga gcagauucgu ggagaccgug gccgcccugg cccaccacga gggcaugggc      720

gccagaguga ccgccagcca caccaccgcc augcacagcu acaacggcgc cuacaccagc      780

agacuguuca gacugcugaa gaugagcggc aucaacuucg uggccaaccc ccuggugaac      840

auccaccugc agggcagauu cgacaccuac cccaagagaa gaggcaucac cagagugaag      900

gagaugcugg agagcggcau caacgugugc uucggccacg acgacguguu cgaccccugg      960

uacccccugg gcaccgccaa caugcugcag gugcugcaca ugggccugca cgugugccag     1020

cugaugggcu acggccagau caacgacggc cugaaccuga ucacccacca cagcgccaga     1080

acccugaacc ugcaggacua cggcaucgcc gccggcaaca gcgccaaccu gaucauccug     1140

cccgccgaga acggcuucga cgcccugaga agacaggugc ccgugagaua cagcgugaga     1200

ggcggcaagg ugaucgccag cacccagccc gcccagacca ccguguaccu ggagcagccc     1260

gaggccaucg acuacaagag auga                                            1284


<210>  5367
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5367
augagcaaca augcccugca gaccaucauu aacgcuagac uccccggcga ggaagggcug       60

uggcaaaucc accuucagga cggaaagauu uccgccaucg augcgcaguc uggcgugaug      120

ccuauuacag agaauagccu ggacgcugaa caggggcucg ucaucccgcc cuucguugag      180

ccucauaucc accuggauac gacccaaaca gccggacagc ccaacuggaa ucaguccggc      240

acccuuuuug aagggauuga gcggugggcc gagcgcaaag cucugcucac acaugacgau      300

gugaagcaga gagccuggca aacccugaaa uggcagaucg cuaacggcau ucagcacgug      360

cggacacaug ucgacguguc ugaugccacc cugacggcgc ucaaggccau gcuggaaguu      420

aaacaggagg uggcuccuug gaucgaccuu caaauugucg ccuuccccca ggaaggaauc      480

cugagcuacc cuaauggcga ggcucuccug gaggaagccc uucgccuggg ggcggaugug      540

guuggagcca uuccgcacuu ugaguucacc agagaauaug gcguggaguc ccuccacaag      600

acauuugcuc uggcccagaa guacgaccgg cugaucgaug uccauugcga cgaaaucgau      660

gacgagcaau cucgcuucgu ggagaccgug gcugcccucg cccaccauga agggauggga      720

gcuagaguca cagcgagcca caccacggcc augcacuccu auaacggcgc uuacacaagc      780

cggcuguuuc gccuucugaa aaugucuggg auuaauuucg uugccaaccc ccucgugaau      840

auccaucugc agggaagauu ugacaccuau ccuaagcggc gcggcauuac aagagugaaa      900

gagaugcuug aauccggcau caacgucugu uucgggcacg augacguguu ugaucccugg      960

uacccucugg gaaccgccaa uaugcuccag guucugcaua ugggccugca cgugugccag     1020

cucauggggu auggacaaau uaacgacggc cugaaucuua ucacccauca cagcgcucgg     1080

acacugaacc uccaggauua cgggaucgcc gcgggaaacu cugcuaaucu gauuauccuu     1140

cccgccgaga acggcuucga cgcccugcgc agacaggucc cggugcggua cuccguuaga     1200

ggcgggaagg ugauugcuag cacgcagccu gcccaaacca cagucuaucu cgaacagccc     1260

gaggcuaucg auuacaaacg cuga                                            1284


<210>  5368
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAP92816

<400>  5368
augucaaaua acgcauuaca aacaauaaua aaugcaagac uacccggaga agaaggacua       60

uggcaaauac acuuacaaga cggaaaaauc agugcuaucg augcacaauc aggaguaaug      120

ccaauaacug aaaauagccu agacgcagaa caaggccuag uaauaccacc auuuguugaa      180

ccgcauauac accuagacac aacacaaaca gcagggcaac caaacuggaa ccaaucagga      240

acacuauuug aaggaauaga aagaugggcu gaaagaaaag cacuacuaac acacgacgac      300

guaaaacaac gagccuggca aacacuaaaa uggcaaauag caaacggaau acaacacguu      360

agaacucaug uagaugucuc agaugcaaca uuaacagcgu uaaaagcaau gcuugaagua      420

aaacaagaag uugcaccaug gauagacuua cagauaguag cauuccccca agaaggaaua      480

cuaucauacc cuaacggaga agcauuacuu gaagaagcuc uaagacuagg cgcagaugua      540

guaggagcaa uaccacacuu cgaauuuaca agagaauacg gaguagaauc acuacacaaa      600

acauucgcuu uagcacaaaa auaugaccga uuaauagacg uucacugcga cgaaaucgac      660

gaugagcaau cuagauucgu agaaacagua gcugccuuag cucaucacga aggaaugggg      720

gcaagaguaa cagcaucuca uacaacagcu augcacuccu acaacggagc auacacaagu      780

cgacuauuua gauuauuaaa aaugucaggc auaaauuuug uagcaaaucc acuaguaaau      840

auacacuuac aagguagauu ugauacauac ccaaaacgac gaggaauaac aagaguaaaa      900

gaaaugcuag aaagcggcau aaauguaugc uucggacacg acgacguauu cgauccaugg      960

uauccccuag gaacagcaaa uaugcuacaa guuuuacaua ugggacuaca cguaugucaa     1020

uuaaugggau acggacaaau aaaugacggc cuaaaucuga uaacacacca cucagcacga     1080

acacuaaauu uacaagacua cggaauagca gcaggaaaca gcgcaaaccu uaucauauua     1140

ccagcagaaa acggauuuga cgcauuaaga agacaaguac caguuagaua uuccguaaga     1200

ggaggaaaag uaauagcauc uacacaacca gcacaaacaa caguauaccu agaacaacca     1260

gaagcaauag auuacaaaag auaa                                            1284


<210>  5369
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__Q6Q8Q1

<400>  5369

Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425         


<210>  5370
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5370
augucgaaua acgcuuuaca aacaauuauu aacgcccggu uaccaggcga agaggggcug       60

uggcagauuc aucugcagga cggaaaaauc agcgccauug augcgcaauc cggcgugaug      120

cccauaacug aaaacagccu ggaugccgaa caagguuuag uuauaccgcc guuuguggag      180

ccacauauuc accuggacac cacgcaaacc gccggacaac cgaacuggaa ucaguccggc      240

acgcuguuug aaggcauuga acgcugggcc gagcgcaaag cguuauuaac ccaugacgau      300

gugaaacaac gcgcauggca gacgcugaaa uggcagauug ccaacggcau ucagcaugug      360

cguacccaug ucgauguuuc ggaugcaacg cuaacugcgc ugaaagcaau gcuggaagug      420

aagcaggaag ucgcgccgug gauugaucug caaaucgucg ccuucccuca ggaagggauu      480

uugucguauc ccaacgguga agcguugcug gaagaggcgu uacgcuuaag ggcagaugua      540

gugggggcga uuccgcauuu ugaauuuacc cgugaauacg gcguggaguc gcugcauaaa      600

accuucgccc uggcgcaaaa auacgaccgu cucaucgacg uucacuguga ugagaucgau      660

gacgagcagu cgcgcuuugu cgaaaccguu gcugcccugg cgcaccauga aggcaugggc      720

gcgcgaguca ccgccagcca caccacggca augcacuccu auaacggggc guauaccuca      780

cgccuguucc gcuugcugaa aauguccggu auuaacuuug ucgccaaccc gcuggucaau      840

auucaucugc aaggacguuu cgauacguau ccaaaacguc gcggcaucac gcgcguuaaa      900

gagaugcugg aguccggcau uaacgucugc uuuggucacg augaugucuu cgauccgugg      960

uauccgcugg gaacggcgaa uaugcugcaa gugcugcaua uggggcugca uguuugccag     1020

uugaugggcu acgggcagau uaacgauggc cugaauuuaa ucacccacca cagcgcaagg     1080

acguugaauu ugcaggauua cggcauugcc gccggaaaca gcgccaaccu gauuauccug     1140

ccggcugaaa auggguuuga ugcgcugcgc cgucagguuc cgguacguua uucgguacgu     1200

ggcggcaagg ugauugccag cacacaaccg gcacaaacca ccguauaucu ggagcagcca     1260

gaagccaucg auuacaaacg uuga                                            1284


<210>  5371
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5371
augagcaaca acgcccugca gaccaucauc aacgcccgcc uccccggcga ggaggggcug       60

uggcagaucc accuccagga cggcaagauc uccgcgaucg acgcccagag cggggugaug      120

ccgaucaccg agaacucccu ggacgccgag cagggccugg ucaucccgcc cuucguggag      180

ccccacaucc accuggacac gacccagacc gccgggcagc ccaacuggaa ccagagcggc      240

acccucuucg agggcaucga gcggugggcc gagcgcaagg cgcugcugac gcacgacgac      300

gugaagcagc gggccuggca gacccucaag uggcagaucg ccaacgggau ccagcacguc      360

cgcacccacg uggacguguc cgacgccacc cugacggcgc ugaaggccau gcucgagguc      420

aagcaggagg uggcccccug gaucgaccug cagaucgugg ccuuccccca ggagggcauc      480

cugagcuacc ccaacgggga ggcccuccug gaggaggcgc ugcggcuccg cgccgacguc      540

gugggcgcca ucccgcacuu cgaguucacc cgggaguacg ggguggaguc ccugcacaag      600

accuucgccc uggcccagaa guacgaccgc cucaucgacg uccacugcga cgagaucgac      660

gacgagcaga gccgguucgu ggagaccgug gcggcccugg cccaccacga gggcaugggc      720

gcccgcguca cggccuccca caccaccgcg augcacagcu acaacggggc cuacaccucc      780

cggcuguucc gccuccugaa gaugagcggc aucaacuucg uggccaaccc ccuggugaac      840

auccaccucc aggggcgguu cgacacguac cccaagcgcc ggggcaucac ccgcgucaag      900

gagaugcugg aguccggcau caacgugugc uucgggcacg acgacguguu cgaccccugg      960

uacccgcugg gcaccgccaa caugcuccag guccugcaca uggggcugca cgugugccag     1020

cucaugggcu acgggcagau caacgacggc cugaaccuga ucacccacca cagcgcccgg     1080

acgcucaacc ugcaggacua cggcaucgcg gccgggaacu ccgccaaccu gaucauccuc     1140

cccgccgaga acggcuucga cgcgcugcgc cgccaggugc ccguccggua cagcgugcgc     1200

gggggcaagg ucaucgccuc cacccagccc gcccagacca ccguguaccu ggagcagccg     1260

gaggccaucg acuacaagcg guga                                            1284


<210>  5372
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5372
auguccaaca acgcccucca gaccaucauc aacgcccgcc uccccggcga ggagggccuc       60

uggcagaucc accuccagga cggcaagauc uccgccaucg acgcccaguc cggcgucaug      120

cccaucaccg agaacucccu cgacgccgag cagggccucg ucaucccccc cuucgucgag      180

ccccacaucc accucgacac cacccagacc gccggccagc ccaacuggaa ccaguccggc      240

acccucuucg agggcaucga gcgcugggcc gagcgcaagg cccuccucac ccacgacgac      300

gucaagcagc gcgccuggca gacccucaag uggcagaucg ccaacggcau ccagcacguc      360

cgcacccacg ucgacgucuc cgacgccacc cucaccgccc ucaaggccau gcucgagguc      420

aagcaggagg ucgcccccug gaucgaccuc cagaucgucg ccuuccccca ggagggcauc      480

cucuccuacc ccaacggcga ggcccuccuc gaggaggccc uccgccuccg cgccgacguc      540

gucggcgcca ucccccacuu cgaguucacc cgcgaguacg gcgucgaguc ccuccacaag      600

accuucgccc ucgcccagaa guacgaccgc cucaucgacg uccacugcga cgagaucgac      660

gacgagcagu cccgcuucgu cgagaccguc gccgcccucg cccaccacga gggcaugggc      720

gcccgcguca ccgccuccca caccaccgcc augcacuccu acaacggcgc cuacaccucc      780

cgccucuucc gccuccucaa gauguccggc aucaacuucg ucgccaaccc ccucgucaac      840

auccaccucc agggccgcuu cgacaccuac cccaagcgcc gcggcaucac ccgcgucaag      900

gagaugcucg aguccggcau caacgucugc uucggccacg acgacgucuu cgaccccugg      960

uacccccucg gcaccgccaa caugcuccag guccuccaca ugggccucca cgucugccag     1020

cucaugggcu acggccagau caacgacggc cucaaccuca ucacccacca cuccgcccgc     1080

acccucaacc uccaggacua cggcaucgcc gccggcaacu ccgccaaccu caucauccuc     1140

cccgccgaga acggcuucga cgcccuccgc cgccaggucc ccguccgcua cuccguccgc     1200

ggcggcaagg ucaucgccuc cacccagccc gcccagacca ccgucuaccu cgagcagccc     1260

gaggccaucg acuacaagcg cuga                                            1284


<210>  5373
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5373
augagcaaca augcccugca gaccaucauu aacgcuagac uccccggcga ggaagggcuu       60

uggcaaauac aucugcagga cggaaagauc uccgcaauug augcccaguc uggugugaug      120

ccuaucacag agaauaguuu ggacgcggaa cagggcuuag ucauuccacc guucguugag      180

ccccacaucc accuggauac uacgcaaacc gcugggcagc cuaacuggaa ucagagugga      240

acacuauuug aaggcauaga gaggugggcc gagcggaaag cacuccugac ucaugacgau      300

gugaagcagc gcgccuggca aacccuuaaa uggcagaucg cuaacgguau ucagcacgua      360

cgaacacaug uggacgucag cgaugcaacc cugacugccu ugaaggcuau gcucgaagug      420

aaacaggagg uugccccaug gaucgaccug caaauugugg cguuccccca ggaagggauc      480

cuguccuacc cuaauggaga ggcacucuua gaggaagccc ugcgucuuag agcugauguc      540

gugggcgcca uaccacacuu ugaguucaca agggaauaug gcguagaguc uuugcacaag      600

accuuugcac uggcucagaa guacgaccgg cuaauugaug uucauugcga cgaaaucgau      660

gacgagcaau cgcgcuucgu ggagacgguc gccgcgcucg cccaccauga agggauggga      720

gcaagaguga cugcuucaca caccacagcc augcacagcu auaacggugc uuacacuuca      780

aggcuguuuc ggcuucugaa aauguccggc auuaauuucg uggccaaccc cuuggucaau      840

auccaucucc aggggcgcuu ugacaccuau ccuaagcgaa gaggaaucac aaggguuaaa      900

gagaugcugg aaucuggcau uaacgugugu uucggucacg augacguauu ugauccaugg      960

uacccguuag ggaccgcaaa uaugcuccag gugcugcaua ugggacuuca cgucugccag     1020

cugaugggcu auggccaaau aaacgacggg uugaaucuaa ucacgcauca cagcgcccgg     1080

acucugaacc uccaggauua cggaauugcu gcggguaacu ccgcaaaucu gaucauacuu     1140

cccgccgaga acggcuucga cgcucugcgu cgccaggugc cuguuagaua cucagugagg     1200

ggagggaagg ucauugccag uacacagcca gcacaaacca cuguguauuu ggaacagccc     1260

gaggccaucg auuacaaacg guga                                            1284


<210>  5374
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5374
augagcaaca acgcccugca gaccaucauc aacgccagac ugcccggcga ggagggccug       60

uggcagaucc accugcagga cggcaagauc agcgccaucg acgcccagag cggcgugaug      120

cccaucaccg agaacagccu ggacgccgag cagggccugg ugaucccccc cuucguggag      180

ccccacaucc accuggacac cacccagacc gccggccagc ccaacuggaa ccagagcggc      240

acccuguucg agggcaucga gagaugggcc gagagaaagg cccugcugac ccacgacgac      300

gugaagcaga gagccuggca gacccugaag uggcagaucg ccaacggcau ccagcacgug      360

agaacccacg uggacgugag cgacgccacc cugaccgccc ugaaggccau gcuggaggug      420

aagcaggagg uggcccccug gaucgaccug cagaucgugg ccuuccccca ggagggcauc      480

cugagcuacc ccaacggcga ggcccugcug gaggaggccc ugagacugag agccgacgug      540

gugggcgcca ucccccacuu cgaguucacc agagaguacg gcguggagag ccugcacaag      600

accuucgccc uggcccagaa guacgacaga cugaucgacg ugcacugcga cgagaucgac      660

gacgagcaga gcagauucgu ggagaccgug gccgcccugg cccaccacga gggcaugggc      720

gccagaguga ccgccagcca caccaccgcc augcacagcu acaacggcgc cuacaccagc      780

agacuguuca gacugcugaa gaugagcggc aucaacuucg uggccaaccc ccuggugaac      840

auccaccugc agggcagauu cgacaccuac cccaagagaa gaggcaucac cagagugaag      900

gagaugcugg agagcggcau caacgugugc uucggccacg acgacguguu cgaccccugg      960

uacccccugg gcaccgccaa caugcugcag gugcugcaca ugggccugca cgugugccag     1020

cugaugggcu acggccagau caacgacggc cugaaccuga ucacccacca cagcgccaga     1080

acccugaacc ugcaggacua cggcaucgcc gccggcaaca gcgccaaccu gaucauccug     1140

cccgccgaga acggcuucga cgcccugaga agacaggugc ccgugagaua cagcgugaga     1200

ggcggcaagg ugaucgccag cacccagccc gcccagacca ccguguaccu ggagcagccc     1260

gaggccaucg acuacaagag auga                                            1284


<210>  5375
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5375
augagcaaca augcccugca gaccaucauu aacgcuagac uccccggcga ggaagggcug       60

uggcaaaucc accuucagga cggaaagauu uccgccaucg augcgcaguc uggcgugaug      120

ccuauuacag agaauagccu ggacgcugaa caggggcucg ucaucccgcc cuucguugag      180

ccucauaucc accuggauac gacccaaaca gccggacagc ccaacuggaa ucaguccggc      240

acccuuuuug aagggauuga gcggugggcc gagcgcaaag cucugcucac acaugacgau      300

gugaagcaga gagccuggca aacccugaaa uggcagaucg cuaacggcau ucagcacgug      360

cggacacaug ucgacguguc ugaugccacc cugacggcgc ucaaggccau gcuggaaguu      420

aaacaggagg uggcuccuug gaucgaccuu caaauugucg ccuuccccca ggaaggaauc      480

cugagcuacc cuaauggcga ggcucuccug gaggaagccc uucgccugag agcggaugug      540

guuggggcca uuccgcacuu ugaguucacc cgggaauaug gaguggaguc ccuccacaag      600

acauuugcuc uggcccagaa guacgaccgc cugaucgaug uccauugcga cgaaaucgau      660

gacgagcaau cuagauucgu ggagaccgug gcugcccucg cccaccauga aggcaugggg      720

gcucggguca cagcgagcca caccacggcc augcacuccu auaacggagc uuacacaagc      780

cgccuguuua gacuucugaa aaugucuggc auuaauuucg uugccaaccc ccucgugaau      840

auccaucugc aggggcgguu ugacaccuau ccuaagcgca gaggaauuac acgggugaaa      900

gagaugcuug aauccggcau caacgucugu uucggccacg augacguguu ugaucccugg      960

uacccucugg ggaccgccaa uaugcuccag guucugcaua ugggacugca cgugugccag     1020

cucaugggcu augggcaaau uaacgacgga cugaaucuua ucacccauca cagcgcucgc     1080

acacugaacc uccaggauua cggcaucgcc gcggggaacu cugcuaaucu gauuauccuu     1140

cccgccgaga acggauucga cgcccugaga cggcaggucc cggugagaua cuccguucgc     1200

ggcggcaagg ugauugcuag cacgcagccu gcccaaacca cagucuaucu cgaacagccc     1260

gaggcuaucg auuacaaacg guga                                            1284


<210>  5376
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__AAS58473

<400>  5376
augaguaaca acgcauuaca aacaauaaua aaugcgagau uaccagguga agaaggacuu       60

uggcaaauac auuuacaaga uggaaaaaua ucugcaauag acgcacaaag cggaguaaug      120

ccaauaacag aaaauucacu agaugcagaa caaggauuag uaauaccacc uuucguagaa      180

ccacauauac auuuagacac uacacaaaca gcaggucaac caaacuggaa ccaaucagga      240

acauuauuug aaggaauaga gagaugggcc gaaagaaaag ccuuacuaac acacgacgac      300

gucaaacaaa gagcauggca aacauuaaaa uggcaaauag caaacggaau acaacaugua      360

agaacacaug uagacguaag ugacgcaaca cuaacagcac uaaaagcaau guuagaagua      420

aagcaagaag uagcaccaug gauagaucua caaauaguag cauuccccca agaaggaaua      480

cuaucauauc caaacggaga agcacuacuu gaagaagccc uaagacuaag agcagaugua      540

guaggagcaa uaccacacuu ugaauucaca agagaauacg gaguagaauc acuacauaaa      600

acuuuugccc uagcacaaaa auacgauaga cuaauagaug uacauuguga cgaaauagac      660

gaugaacaau cacgauucgu ugaaaccguc gcugcacuag cacaucacga agggaugggu      720

gcaagaguaa cagcuucaca cacaacugcc augcacucuu auaacggagc auacacaagc      780

agauuauuca gacuauuaaa aaugagugga auaaacuuug uagcuaaucc ccuaguaaau      840

auacauuuac aagguagauu ugacacauac ccgaaaagaa gaggaauaac aagaguaaaa      900

gaaaugcuag aaagcggcau aaacguaugu uucggacaug acgacguauu cgaccccugg      960

uauccauuag gaacagccaa cauguuacaa guccuacaca ugggccuaca ugucugccaa     1020

cuuaugggau acggacaaau uaacgacgga cuaaacuuaa ucacacauca uuccgcaaga     1080

acacucaauu uacaagacua ugguauagca gcaggaaacu cagcuaaccu aauaauacua     1140

ccugcagaaa acggcuucga cgcauuaaga agacaaguuc caguaagaua cucaguacga     1200

ggagggaaag uaauagcauc aacgcaacca gcucaaacaa caguauauuu agaacaacca     1260

gaagcaauag acuauaaaag auaa                                            1284


<210>  5377
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__W8ZNH5

<400>  5377

Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      


Ala Arg Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Phe His Asp 
            20                  25                  30          


Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Val Thr 
        35                  40                  45              


Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Leu Pro Pro Phe Val 
    50                  55                  60                  


Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  


Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      


Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         


Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             


Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 


Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 


Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     


Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         


Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             


Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 


Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 


Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     


His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         


Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             


Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 


Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 


Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     


Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         


Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             


Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 


Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 


Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Lys Pro Ala 
                405                 410                 415     


Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         






<210>  5378
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5378
auguggaggc uaacaguguc gaauaaugcu uuacaaacaa uuauuaacgc ccgguuaccc       60

ggcaaagagg ggcuguggca gauucauuuu cacgacggaa aaaucagcgc cauugaugcg      120

caauccggcg ugaugcccgu aacugaaaac agccuggaug ccgaacaagg uuuaguuuua      180

ccgccguuug uggagccgca uauucaccug gacaccacgc aaaccgccgg acaaccgaac      240

uggaaucagu ccggcacgcu guuugaaggc auugaacgcu gggccgagcg caaagcguua      300

uuaacucaug acgaugugaa acaacgcgca uggcaaacgc ugaaauggca gauugccaac      360

ggcauucagc augugcguac ccaugucgau guuucggacg caacgcugac ugcgcugaaa      420

gcaaugcugg aagugaaaca ggaaguugcg ccguggauug aucuacaaau cgucgccuuc      480

ccgcaggaag ggauuuuguc guaucccaau ggugaagcgu ugcuggaaga ggcguuacgc      540

uuaggggcag acguuguugg ggcgauuccg cauuuugaau uuacccguga auauggcgug      600

gagucgcugc auaaaaccuu cgcccuggcg caaaaauacg accgucucau cgauguucac      660

ugugacgaga uugaugauga gcaaucacgc uuugucgaaa ccguugcugc ccuggcgcac      720

cgugaaggca ugggcgcgcg agucaccgcc agccauacua cggcaaugca cuccuauaac      780

ggggcguaua cuucgcgccu guuucguuug cugaaaaugu ccgguauuaa cuuugucgcc      840

aacccguugg ucaauauuca ucugcaagga cguuucgaua cguauccaaa acgucgcggc      900

aucacgcgcg uuaaagagau gcuggagucc ggcauuaacg ucugcuuugg ucacgaugau      960

gucuucgauc cgugguaucc gcugggaacg gcgaauaugc ugcaagugcu gcauaugggg     1020

cugcauguuu gccagcugau gggcuauggg cagauuaacg acggccugaa uuuaaucacc     1080

caccacagug ccagaacguu gaauuugcag gauuacggca uugccgccgg aaacagcgcc     1140

aaccugauua uccugccggc ugaaaauggg uuugacgcgc ugcgccguca gguuccggug     1200

cgcuauucgg uacguggcgg caaggugauu gccagcacaa aaccggcaca aaccaccgua     1260

uaucuggagc agccagaagc caucgauuac aaacgguaa                            1299


<210>  5379
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5379
auguggcgcc ugaccgugag caacaacgcc cuccagacca ucaucaacgc ccggcugccc       60

ggcaaggagg ggcuguggca gauccacuuc cacgacggca agaucuccgc gaucgacgcc      120

cagagcgggg ucaugccggu gacggagaac ucccucgacg ccgagcaggg ccuggugcug      180

ccgcccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg gcagcccaac      240

uggaaccaga gcggcacgcu guucgagggc aucgagcgcu gggccgagcg gaaggcgcug      300

cucacccacg acgacgugaa gcagcgcgcc uggcagaccc ugaaguggca gaucgccaac      360

gggauccagc acgugcggac ccacgucgac guguccgacg ccacgcugac cgcgcucaag      420

gccaugcugg aggugaagca ggaggucgcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccucag cuaccccaac ggggaggccc ugcuggagga ggcgcuccgc      540

cugggcgccg acguggucgg ggccaucccg cacuucgagu ucacccggga guacggcgug      600

gagucccugc acaagaccuu cgcccucgcc cagaaguacg accgccugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagccgg uucgucgaga cgguggcggc ccuggcccac      720

cgcgagggca ugggggcccg ggugaccgcc ucccacacca ccgcgaugca cagcuacaac      780

ggcgccuaca cgucccgccu cuuccggcug cugaagauga gcgggaucaa cuucgucgcc      840

aacccccucg ugaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcggcgcggc      900

aucacccggg ugaaggagau gcuggagucc gggaucaacg ucugcuucgg ccacgacgac      960

guguucgacc ccugguaccc gcuggggacc gccaacaugc uccaggugcu gcacaugggc     1020

cugcacgucu gccagcugau gggguacggc cagaucaacg acggccugaa ccucaucacg     1080

caccacagcg cccgcacccu gaaccugcag gacuacggga ucgcggccgg caacuccgcc     1140

aaccucauca uccugcccgc cgagaacggg uucgacgcgc ugcggcgcca ggugcccguc     1200

cgguacagcg ugcgcggcgg gaaggugauc gccuccacca agcccgccca gaccacgguc     1260

uaccucgagc agccggaggc caucgacuac aagcgcuga                            1299


<210>  5380
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5380
auguggcgcc ucaccgucuc caacaacgcc cuccagacca ucaucaacgc ccgccucccc       60

ggcaaggagg gccucuggca gauccacuuc cacgacggca agaucuccgc caucgacgcc      120

caguccggcg ucaugcccgu caccgagaac ucccucgacg ccgagcaggg ccucguccuc      180

ccccccuucg ucgagcccca cauccaccuc gacaccaccc agaccgccgg ccagcccaac      240

uggaaccagu ccggcacccu cuucgagggc aucgagcgcu gggccgagcg caaggcccuc      300

cucacccacg acgacgucaa gcagcgcgcc uggcagaccc ucaaguggca gaucgccaac      360

ggcauccagc acguccgcac ccacgucgac gucuccgacg ccacccucac cgcccucaag      420

gccaugcucg aggucaagca ggaggucgcc cccuggaucg accuccagau cgucgccuuc      480

ccccaggagg gcauccucuc cuaccccaac ggcgaggccc uccucgagga ggcccuccgc      540

cucggcgccg acgucgucgg cgccaucccc cacuucgagu ucacccgcga guacggcguc      600

gagucccucc acaagaccuu cgcccucgcc cagaaguacg accgccucau cgacguccac      660

ugcgacgaga ucgacgacga gcagucccgc uucgucgaga ccgucgccgc ccucgcccac      720

cgcgagggca ugggcgcccg cgucaccgcc ucccacacca ccgccaugca cuccuacaac      780

ggcgccuaca ccucccgccu cuuccgccuc cucaagaugu ccggcaucaa cuucgucgcc      840

aacccccucg ucaacaucca ccuccagggc cgcuucgaca ccuaccccaa gcgccgcggc      900

aucacccgcg ucaaggagau gcucgagucc ggcaucaacg ucugcuucgg ccacgacgac      960

gucuucgacc ccugguaccc ccucggcacc gccaacaugc uccagguccu ccacaugggc     1020

cuccacgucu gccagcucau gggcuacggc cagaucaacg acggccucaa ccucaucacc     1080

caccacuccg cccgcacccu caaccuccag gacuacggca ucgccgccgg caacuccgcc     1140

aaccucauca uccuccccgc cgagaacggc uucgacgccc uccgccgcca gguccccguc     1200

cgcuacuccg uccgcggcgg caaggucauc gccuccacca agcccgccca gaccaccguc     1260

uaccucgagc agcccgaggc caucgacuac aagcgcuga                            1299


<210>  5381
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5381
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc uaggcuuccc       60

ggcaaggagg ggcuguggca aauacacuuc caugacggaa aaaucuccgc aauugaugcc      120

cagucuggug ucaugccugu uacugaaaau ucauuggacg cggagcaggg cuuagugcug      180

ccaccguuug uagaacccca cauccaucua gauacgaccc agacagcugg gcaaccuaac      240

uggaaucaga guggaacucu cuucgagggc auugaacggu gggccgagcg caaggcacug      300

cuuacccacg acgaugugaa acagcgagcc uggcagacac ugaaguggca aaucgcuaac      360

gguauacagc auguccguac ccacguggac guuagcgaug caacuuugac agcccucaaa      420

gcuaugcugg aggugaagca ggaagucgcc ccauggaucg accugcagau uguggcguuu      480

ccccaagagg ggauccucuc cuacccuaau ggagaagcau uacuggagga ggcccuuaga      540

uugggcgcug auguaguugg cgccauucca cacuucgaau uuaccaggga guauggggug      600

gaaucucugc auaagacguu cgcacuagcu cagaaauacg accggcucau cgauguccac      660

ugcgacgaga uagaugacga acagucgcgc uuuguggaga cuguggccgc gcuggcccau      720

agagagggaa ugggugcaag ggucaccgcu ucacacacaa cugccaugca cagcuauaac      780

ggcgcuuaca ccagucggcu uuuccgccug uugaagaugu ccgggauuaa uuuuguugcc      840

aacccccucg ugaauaucca ucugcaagga cgauucgaca cauauccuaa aagaaggggc      900

auuacccggg uaaaggaaau guuagagucu gguaucaacg uguguuuugg gcacgaugac      960

gucuucgauc caugguaccc gcugggaacg gcaaauaugc uccaggugcu ucauaugggc     1020

cugcacguuu gccaguugau gggcuauggg cagaucaacg acggacuaaa ucugauuacu     1080

caucacagcg cccguacacu caaccugcaa gauuacggua uagcugcggg caacuccgca     1140

aaucuuauca uucugcccgc cgaaaacggg uuugacgcuu ugcgcagaca ggugccuguc     1200

agguacucag ugcggggagg caaaguaauc gccaguacca agccagcaca gacuacaguu     1260

uaucucgagc agcccgaagc cauagauuac aagcgauga                            1299


<210>  5382
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5382
auguggagac ugaccgugag caacaacgcc cugcagacca ucaucaacgc cagacugccc       60

ggcaaggagg gccuguggca gauccacuuc cacgacggca agaucagcgc caucgacgcc      120

cagagcggcg ugaugcccgu gaccgagaac agccuggacg ccgagcaggg ccuggugcug      180

ccccccuucg uggagcccca cauccaccug gacaccaccc agaccgccgg ccagcccaac      240

uggaaccaga gcggcacccu guucgagggc aucgagagau gggccgagag aaaggcccug      300

cugacccacg acgacgugaa gcagagagcc uggcagaccc ugaaguggca gaucgccaac      360

ggcauccagc acgugagaac ccacguggac gugagcgacg ccacccugac cgcccugaag      420

gccaugcugg aggugaagca ggagguggcc cccuggaucg accugcagau cguggccuuc      480

ccccaggagg gcauccugag cuaccccaac ggcgaggccc ugcuggagga ggcccugaga      540

cugggcgccg acgugguggg cgccaucccc cacuucgagu ucaccagaga guacggcgug      600

gagagccugc acaagaccuu cgcccuggcc cagaaguacg acagacugau cgacgugcac      660

ugcgacgaga ucgacgacga gcagagcaga uucguggaga ccguggccgc ccuggcccac      720

agagagggca ugggcgccag agugaccgcc agccacacca ccgccaugca cagcuacaac      780

ggcgccuaca ccagcagacu guucagacug cugaagauga gcggcaucaa cuucguggcc      840

aacccccugg ugaacaucca ccugcagggc agauucgaca ccuaccccaa gagaagaggc      900

aucaccagag ugaaggagau gcuggagagc ggcaucaacg ugugcuucgg ccacgacgac      960

guguucgacc ccugguaccc ccugggcacc gccaacaugc ugcaggugcu gcacaugggc     1020

cugcacgugu gccagcugau gggcuacggc cagaucaacg acggccugaa ccugaucacc     1080

caccacagcg ccagaacccu gaaccugcag gacuacggca ucgccgccgg caacagcgcc     1140

aaccugauca uccugcccgc cgagaacggc uucgacgccc ugagaagaca ggugcccgug     1200

agauacagcg ugagaggcgg caaggugauc gccagcacca agcccgccca gaccaccgug     1260

uaccuggagc agcccgaggc caucgacuac aagagauga                            1299


<210>  5383
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5383
auguggagac ugaccgugag caacaaugcc cuccagacaa ucauuaacgc ucggcugccc       60

ggcaaggagg ggcuuuggca aauccacuuc caugacggaa aaauuuccgc caucgaugcg      120

cagucuggcg ucaugccugu uacggaaaau agccuggacg cugagcaggg gcucgugcug      180

ccgcccuuug uggaaccuca cauucaucuu gauaccacac agaccgccgg acaacccaac      240

uggaaucagu ccggcacacu guucgagggg aucgaacgcu gggccgagag aaaggcucuc      300

cugacccacg acgaugucaa acagcgggcc uggcagacac ugaaguggca aaucgcuaac      360

ggcauucagc augugcgcac ccacguugac gugucugaug ccacgcucac cgcgcugaaa      420

gccaugcuug aggucaagca ggaaguggcu ccuuggaucg accugcagau uguugccuuu      480

ccccaagagg gaauccucag cuacccuaau ggcgaagcuc ugcuugagga ggcccugaga      540

cucggggcgg auguggucgg agccauuccg cacuucgaau uuacacggga guauggcgug      600

gaaucccugc auaagaccuu cgcucuggcc cagaaauacg accgccucau cgaugugcac      660

ugcgacgaga uugaugacga acagucuaga uuugucgaga caguugcugc ccuggcccau      720

cgggagggga ugggagcucg cgugaccgcg agccacacga cagccaugca cuccuauaac      780

ggcgcuuaca ccagcagacu uuuccggcug cucaagaugu cugggaucaa uuuuguggcc      840

aacccccugg ucaauaucca ucuucaagga cgcuucgaca cauauccuaa aagacggggc      900

auuacccgcg ugaaggaaau gcuggagucc ggcaucaacg uuuguuuugg gcacgaugac      960

guguucgauc ccugguaccc ucucggaacc gccaauaugc ugcagguccu gcauaugggc     1020

cuccacgugu gccagcugau gggguaugga cagauuaacg acggccuuaa ucugaucaca     1080

caucacagcg cuagaacgcu caaccugcaa gauuacggga uugccgcggg aaacucugcu     1140

aaucuuauca uccugcccgc cgaaaacggc uuugacgccc uccggagaca gguuccggug     1200

cgcuacuccg uccggggcgg gaaagugauu gcuagcacca agccugccca gacaaccguc     1260

uaucuggagc agcccgaagc uaucgauuac aagagauga                            1299


<210>  5384
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_codA__Escherichia_coli__CDN80736

<400>  5384
auguggaggu uaacaguauc uaacaacgca cuacaaacaa uaauaaaugc ucgacuucca       60

ggcaaagaag gacuuuggca aauacacuuu caugauggca aaaucagcgc aauagacgca      120

caaucaggag ugaugcccgu caccgaaaau ucauuagacg cagaacaagg acuagucuua      180

cccccauucg uagaaccgca uauacacuua gauacuacac aaacagcagg acaaccaaau      240

uggaaccaau cuggaacacu auucgaagga auagaaagau gggcagaaag aaaagcacua      300

cuaacacacg augacguaaa acaaagagca uggcaaacac uaaaauggca aauagcaaac      360

ggaauccaac acguacgaac acauguagau gucucagacg caacacuaac cgcacuaaaa      420

gcaauguuag aagucaaaca agaaguagca ccauggaucg aucuacaaau aguagcauuu      480

ccacaagaag gaauacugag cuauccaaac ggagaagcau uauuagaaga agcacuaaga      540

cuaggagcag acguaguagg ugcaauacca cauuuugaau uuacaagaga auauggcgua      600

gaaucucucc acaaaacuuu cgcacuagca caaaaauaug auagauuaau agauguacau      660

ugcgaugaaa uagacgauga acagaguaga uucguagaaa caguagcagc acuugcacau      720

agggaaggua ugggcgcaag aguaacagca agucacacaa cagcaaugca cucauacaau      780

ggagcauaua ccaguagacu cuuucgacuc cucaaaaugu caggaauaaa uuuuguagcc      840

aacccucuag uuaauauaca cuuacaagga agauucgaca cauacccuaa aagaagagga      900

auaacaagag uaaaagaaau guuagaauca ggcauaaacg uuuguuuugg acacgaugau      960

guauuugauc cuugguaucc auuaggaaca gccaauaugu uacaaguacu ccauaugggu     1020

uuacauguau gccaauuaau gggauacgga caaaucaaug auggauuaaa cuuaauaaca     1080

caccauucag caagaacacu aaaucuacaa gauuauggaa uagcagccgg aaauucagca     1140

aaucuaauaa uacuaccagc agaaaacgga uuugacgccc ugagaagaca aguaccagua     1200

agauacucag uaagaggagg aaaaguaaua gcaucaacaa aaccagcaca aacaaccgua     1260

uacuuagaac aaccagaagc aauagacuau aaaagauaa                            1299


<210>  5385
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A023ZJG6

<400>  5385

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5386
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5386
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5387
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5387
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5388
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5388
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5389
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5389
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5390
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5390
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5391
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5391
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5392
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AHY78226

<400>  5392
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcgu uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caaggggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauag         477


<210>  5393
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A024XGF7

<400>  5393

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5394
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5394
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5395
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5395
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5396
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5396
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5397
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5397
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5398
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5398
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5399
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5399
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5400
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG88187

<400>  5400
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggga guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaaggc uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5401
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A024XUW9

<400>  5401

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5402
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5402
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5403
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5403
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5404
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5404
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5405
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5405
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5406
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5406
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5407
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5407
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5408
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG92959

<400>  5408
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugccu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu gguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5409
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0C5ITD0

<400>  5409

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5410
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5410
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5411
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5411
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5412
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5412
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5413
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5413
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5414
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5414
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5415
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5415
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5416
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJP42194

<400>  5416
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggguguuu aauaaauaau      120

aaagacggaa guguauuagg aagagggcau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug caaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5417
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4WVI5

<400>  5417

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5418
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5418
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5419
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5419
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5420
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5420
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5421
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5421
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5422
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5422
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5423
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5423
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5424
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91284

<400>  5424
augguaacag gaggaauggc gaguaaaugg gaccaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gagggugucu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggggc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5425
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4WY08

<400>  5425

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5426
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5426
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5427
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5427
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5428
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5428
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5429
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5429
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5430
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5430
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5431
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5431
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5432
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV91722

<400>  5432
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug caaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5433
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4WZA2

<400>  5433

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5434
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5434
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5435
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5435
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5436
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5436
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5437
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5437
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5438
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5438
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5439
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5439
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5440
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92162

<400>  5440
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggau caguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5441
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4WZQ5

<400>  5441

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5442
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5442
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5443
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5443
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5444
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5444
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5445
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5445
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5446
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5446
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5447
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5447
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5448
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV92601

<400>  5448
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaagggaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5449
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X0R8

<400>  5449

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5450
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5450
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5451
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5451
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5452
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5452
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5453
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5453
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5454
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5454
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5455
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5455
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5456
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93034

<400>  5456
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguggacg augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauag         477


<210>  5457
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X195

<400>  5457

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5458
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5458
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5459
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5459
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5460
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5460
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5461
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5461
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5462
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5462
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5463
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5463
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5464
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93300

<400>  5464
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaaguccg ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5465
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X2R9

<400>  5465

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5466
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5466
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugaggu uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucccca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5467
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5467
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5468
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5468
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5469
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5469
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5470
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5470
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5471
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5471
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5472
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV93739

<400>  5472
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa ggaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5473
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X3Q1

<400>  5473

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5474
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5474
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5475
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5475
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5476
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5476
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5477
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5477
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5478
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5478
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5479
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5479
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5480
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94006

<400>  5480
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc gauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5481
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X4K1

<400>  5481

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5482
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5482
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5483
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5483
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5484
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5484
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5485
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5485
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5486
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5486
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5487
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5487
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5488
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94445

<400>  5488
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguacuagg aagaggacau aauaugaggu uucaaaaagg aagcgcaaca      180

uuacauggag aaauaagcac auuagaaaau ugugggaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5489
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X5B7

<400>  5489

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5490
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5490
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5491
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5491
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5492
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5492
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5493
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5493
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5494
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5494
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5495
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5495
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5496
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV94715

<400>  5496
augguaacgg gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5497
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X7R4

<400>  5497

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5498
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5498
auggugacag ggggaauggc aagcaaaugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5499
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5499
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5500
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5500
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5501
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5501
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5502
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5502
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5503
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5503
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5504
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95147

<400>  5504
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uugcauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagccca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5505
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4X7X4

<400>  5505

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5506
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5506
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5507
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5507
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5508
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5508
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5509
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5509
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5510
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5510
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5511
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5511
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5512
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95584

<400>  5512
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag ggggauguuu aauaaauaau      120

aaagauggaa guguauuagg aaggggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caaggggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauag         477


<210>  5513
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XA07

<400>  5513

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5514
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5514
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5515
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5515
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5516
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5516
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5517
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5517
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5518
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5518
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5519
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5519
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5520
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV95852

<400>  5520
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaac ugcggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caaggugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5521
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XA25

<400>  5521

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5522
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5522
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5523
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5523
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5524
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5524
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5525
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5525
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5526
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5526
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5527
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5527
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5528
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96293

<400>  5528
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua gugguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5529
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XAV6

<400>  5529

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asn Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5530
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5530
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucaauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5531
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5531
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucaacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5532
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5532
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucaacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5533
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5533
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauaaacga aagaccgcag gauugguuug aggacaucgg ugaguga         477


<210>  5534
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5534
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucaacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5535
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5535
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauuaacga aagaccccag gauugguuug aggacaucgg cgaguga         477


<210>  5536
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV96709

<400>  5536
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcgu uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaac      120

aaagacggaa gcguguuagg aagaggacau aauaugagau uccaaaaagg aagugcaaca      180

uuacacggag aaauaagcac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gacacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugcgu aguaggagaa aauguaaauu ucaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauaaauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5537
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XCJ5

<400>  5537

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5538
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5538
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5539
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5539
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5540
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5540
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5541
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5541
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5542
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5542
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5543
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5543
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5544
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97145

<400>  5544
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacauggag aaauaaguac auuagaaaau ugcggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5545
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XDL4

<400>  5545

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5546
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5546
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5547
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5547
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5548
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5548
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5549
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5549
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5550
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5550
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5551
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5551
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5552
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV97588

<400>  5552
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg gagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacgacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caaggugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5553
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XG53

<400>  5553

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5554
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5554
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5555
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5555
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5556
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5556
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5557
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5557
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5558
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5558
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5559
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5559
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5560
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98027

<400>  5560
augguaacag gaggaauggc gaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5561
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XGH3

<400>  5561

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5562
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5562
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5563
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5563
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5564
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5564
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5565
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5565
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5566
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5566
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5567
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5567
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5568
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98465

<400>  5568
augguaacag gagggauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcgu uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5569
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XHD4

<400>  5569

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5570
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5570
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5571
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5571
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5572
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5572
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5573
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5573
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5574
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5574
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5575
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5575
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5576
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV98898

<400>  5576
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggggga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaagcac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagagaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5577
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XIK5

<400>  5577

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5578
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5578
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5579
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5579
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5580
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5580
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5581
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5581
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5582
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5582
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5583
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5583
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5584
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99338

<400>  5584
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuggg aaggggacau aauaugagau uucaaaaagg aagugcgaca      180

cuacauggag aaauaaguac acuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguggaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5585
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XJR4

<400>  5585

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5586
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5586
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugaggu uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucccca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5587
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5587
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5588
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5588
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5589
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5589
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5590
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5590
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5591
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5591
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5592
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJV99779

<400>  5592
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguguuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguucg aagauauagg agaauaa         477


<210>  5593
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XL36

<400>  5593

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5594
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5594
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5595
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5595
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5596
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5596
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5597
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5597
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5598
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5598
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5599
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5599
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5600
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00204

<400>  5600
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaagcac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aaggccacaa gauugguuug aagauauagg agaauaa         477


<210>  5601
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XNH2

<400>  5601

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5602
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5602
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5603
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5603
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5604
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5604
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5605
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5605
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5606
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5606
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5607
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5607
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5608
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW00633

<400>  5608
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5609
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XNS1

<400>  5609

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5610
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5610
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5611
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5611
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5612
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5612
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5613
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5613
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5614
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5614
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5615
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5615
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5616
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01072

<400>  5616
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagagggcau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caaggggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5617
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XQY5

<400>  5617

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5618
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5618
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5619
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5619
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5620
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5620
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5621
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5621
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5622
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5622
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5623
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5623
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5624
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01508

<400>  5624
augguaacag gagggauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggga guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uacuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacagu uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5625
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XS80

<400>  5625

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5626
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5626
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5627
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5627
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5628
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5628
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5629
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5629
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5630
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5630
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5631
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5631
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5632
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02360

<400>  5632
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaac      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu ucaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagacga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5633
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XS82

<400>  5633

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5634
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5634
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5635
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5635
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5636
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5636
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5637
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5637
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5638
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5638
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5639
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5639
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5640
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW01943

<400>  5640
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguguuggg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5641
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XTC2

<400>  5641

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5642
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5642
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5643
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5643
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5644
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5644
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5645
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5645
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5646
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5646
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5647
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5647
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5648
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW02785

<400>  5648
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggga guguauuagg aagaggacac aauaugagau uucaaaaagg aagugcaacg      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5649
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XUZ4

<400>  5649

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5650
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5650
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5651
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5651
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5652
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5652
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5653
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5653
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5654
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5654
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5655
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5655
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5656
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03227

<400>  5656
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aaggggacau aauaugagau uucaaaaagg aagugcaaca      180

uugcauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua gugguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5657
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XW26

<400>  5657

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5658
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5658
auggugacag ggggaauggc aagcaaaugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5659
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5659
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5660
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5660
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5661
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5661
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5662
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5662
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5663
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5663
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5664
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW03664

<400>  5664
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacauggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5665
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XXD1

<400>  5665

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5666
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5666
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccccag gauugguuug aagauauugg ugaguag         477


<210>  5667
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5667
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5668
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5668
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5669
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5669
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5670
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5670
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5671
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5671
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5672
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04100

<400>  5672
augguaacag gaggaauggc aaguaaaugg gaucaaaagg gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac acuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguucg aagauauagg agaauaa         477


<210>  5673
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XYH3

<400>  5673

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5674
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5674
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5675
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5675
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5676
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5676
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5677
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5677
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5678
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5678
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5679
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5679
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5680
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04531

<400>  5680
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5681
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4XZT0

<400>  5681

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5682
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5682
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5683
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5683
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5684
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5684
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5685
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5685
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5686
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5686
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5687
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5687
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5688
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW04966

<400>  5688
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcgaca      180

uuacacggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5689
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y164

<400>  5689

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5690
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5690
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5691
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5691
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5692
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5692
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5693
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5693
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5694
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5694
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5695
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5695
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5696
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05404

<400>  5696
augguaacag gaggaauggc aaguaaaugg gaucaaaaag ggauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caaggggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauga         477


<210>  5697
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y2A8

<400>  5697

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5698
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5698
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5699
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5699
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5700
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5700
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5701
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5701
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5702
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5702
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5703
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5703
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5704
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW05846

<400>  5704
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uugcacggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5705
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y3N1

<400>  5705

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5706
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5706
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5707
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5707
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5708
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5708
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5709
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5709
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5710
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5710
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5711
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5711
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5712
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06284

<400>  5712
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagccca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aacguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5713
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y5S3

<400>  5713

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5714
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5714
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5715
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5715
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5716
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5716
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5717
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5717
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5718
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5718
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5719
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5719
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5720
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW06723

<400>  5720
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5721
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y5Y1

<400>  5721

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5722
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5722
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5723
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5723
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5724
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5724
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5725
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5725
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5726
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5726
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5727
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5727
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5728
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07156

<400>  5728
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uccaaaaagg aagugcaaca      180

cuacauggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau ucauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5729
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y7I2

<400>  5729

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5730
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5730
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5731
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5731
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5732
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5732
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5733
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5733
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5734
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5734
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5735
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5735
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5736
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW07594

<400>  5736
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcgu uaggauauaa agaaggggga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu ucaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5737
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Y8S5

<400>  5737

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5738
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5738
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5739
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5739
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5740
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5740
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5741
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5741
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5742
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5742
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5743
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5743
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5744
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08024

<400>  5744
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacaugggg aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagccca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5745
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YAR2

<400>  5745

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5746
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5746
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaggacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5747
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5747
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5748
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5748
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5749
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5749
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5750
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5750
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5751
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5751
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5752
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08463

<400>  5752
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcgaca      180

uuacauggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac acuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccgcaa gauugguuug aagauauagg agaauaa         477


<210>  5753
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YBY2

<400>  5753

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5754
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5754
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5755
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5755
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5756
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5756
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5757
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5757
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5758
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5758
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5759
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5759
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5760
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW08888

<400>  5760
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacgacac uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauag         477


<210>  5761
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YCB3

<400>  5761

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5762
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5762
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5763
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5763
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5764
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5764
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5765
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5765
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5766
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5766
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5767
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5767
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5768
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09327

<400>  5768
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacac aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggggaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5769
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YEC2

<400>  5769

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5770
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5770
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5771
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5771
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5772
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5772
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5773
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5773
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5774
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5774
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5775
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5775
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5776
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW09763

<400>  5776
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaac      120

aaagacggaa guguacuagg aagaggacau aauaugagau uccaaaaagg aagugcaaca      180

cuacacggag aaauaagcac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac acuaucacca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggggaa aauguaaauu ucaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagacga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5777
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YF30

<400>  5777

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5778
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5778
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5779
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5779
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5780
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5780
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5781
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5781
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5782
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5782
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5783
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5783
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5784
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10199

<400>  5784
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugcgacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5785
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YGU2

<400>  5785

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5786
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5786
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5787
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5787
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5788
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5788
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5789
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5789
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5790
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5790
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5791
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5791
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5792
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10633

<400>  5792
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauacacaac auuaagucca ugugacaugu gcacgggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccgcaa gauugguuug aagauauagg agaauaa         477


<210>  5793
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YHN3

<400>  5793

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5794
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5794
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5795
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5795
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5796
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5796
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5797
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5797
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5798
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5798
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5799
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5799
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5800
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW10903

<400>  5800
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aaggccacaa gauugguuug aagauauagg agaauaa         477


<210>  5801
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YIU4

<400>  5801

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5802
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5802
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5803
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5803
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5804
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5804
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5805
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5805
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5806
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5806
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5807
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5807
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5808
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11343

<400>  5808
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauacaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa cgagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5809
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YJ74

<400>  5809

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5810
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5810
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5811
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5811
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5812
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5812
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5813
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5813
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5814
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5814
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5815
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5815
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5816
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW11786

<400>  5816
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5817
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YKC5

<400>  5817

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5818
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5818
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5819
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5819
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5820
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5820
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5821
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5821
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5822
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5822
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5823
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5823
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5824
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12225

<400>  5824
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcgaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aggauauagg agaauag         477


<210>  5825
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YMN8

<400>  5825

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5826
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5826
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5827
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5827
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5828
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5828
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5829
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5829
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5830
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5830
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5831
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5831
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5832
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW12668

<400>  5832
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugccu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uacggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguggua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5833
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YMV6

<400>  5833

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5834
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5834
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5835
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5835
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5836
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5836
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5837
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5837
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5838
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5838
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5839
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5839
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5840
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13105

<400>  5840
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaagcac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5841
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YPP6

<400>  5841

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5842
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5842
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5843
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5843
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5844
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5844
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5845
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5845
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5846
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5846
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5847
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5847
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5848
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13529

<400>  5848
augguaacag gagggauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5849
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YRD4

<400>  5849

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5850
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5850
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5851
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5851
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5852
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5852
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5853
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5853
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5854
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5854
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5855
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5855
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5856
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW13968

<400>  5856
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc gauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5857
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YS13

<400>  5857

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5858
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5858
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaggacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5859
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5859
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5860
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5860
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5861
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5861
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5862
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5862
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5863
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5863
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5864
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14407

<400>  5864
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaacu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caaggggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5865
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YTJ7

<400>  5865

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5866
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5866
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5867
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5867
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5868
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5868
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5869
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5869
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5870
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5870
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5871
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5871
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5872
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW14829

<400>  5872
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac guuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguucg aagauauagg agaauaa         477


<210>  5873
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YUX9

<400>  5873

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5874
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5874
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5875
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5875
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5876
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5876
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5877
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5877
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5878
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5878
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5879
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5879
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5880
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15253

<400>  5880
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5881
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YV34

<400>  5881

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5882
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5882
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5883
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5883
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5884
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5884
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5885
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5885
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5886
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5886
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5887
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5887
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5888
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW15690

<400>  5888
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuagg aagagggcau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacgac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5889
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YXE1

<400>  5889

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5890
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5890
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5891
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5891
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5892
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5892
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5893
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5893
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5894
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5894
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5895
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5895
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5896
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16133

<400>  5896
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaggcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaagcac guuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aaugugaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5897
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YYM6

<400>  5897

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5898
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5898
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5899
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5899
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5900
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5900
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5901
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5901
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5902
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5902
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5903
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5903
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5904
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW16568

<400>  5904
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugccu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu ucaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5905
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4YZB7

<400>  5905

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5906
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5906
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5907
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5907
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5908
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5908
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5909
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5909
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5910
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5910
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5911
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5911
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5912
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17006

<400>  5912
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaacg      180

uuacacggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu agugggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5913
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z060

<400>  5913

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5914
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5914
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5915
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5915
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5916
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5916
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5917
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5917
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5918
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5918
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5919
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5919
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5920
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17430

<400>  5920
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaaguccg ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5921
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z1S2

<400>  5921

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5922
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5922
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5923
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5923
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5924
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5924
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5925
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5925
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5926
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5926
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5927
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5927
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5928
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW17876

<400>  5928
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacac aauaugagau uucaaaaagg aagcgcaaca      180

uuacacggag aaauaagcac acuagaaaau uguggaaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugcgacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagacg acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5929
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z2L6

<400>  5929

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5930
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5930
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5931
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5931
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5932
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5932
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5933
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5933
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5934
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5934
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5935
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5935
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5936
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18315

<400>  5936
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggguauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaucaac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5937
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z4A1

<400>  5937

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5938
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5938
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugaggu uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucccca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5939
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5939
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5940
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5940
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5941
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5941
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5942
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5942
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5943
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5943
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5944
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW18752

<400>  5944
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacac aauaugagau uccaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauag         477


<210>  5945
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z552

<400>  5945

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5946
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5946
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5947
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5947
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5948
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5948
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5949
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5949
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5950
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5950
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5951
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5951
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5952
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19190

<400>  5952
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaggacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu gguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5953
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z6N6

<400>  5953

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5954
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5954
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5955
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5955
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5956
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5956
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5957
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5957
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5958
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5958
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5959
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5959
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5960
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW19616

<400>  5960
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagcgcaaca      180

uuacauggag aaauaaguac acuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caaggugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguggua gugguagaug augaaaggug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5961
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z800

<400>  5961

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5962
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5962
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5963
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5963
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5964
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5964
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5965
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5965
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5966
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5966
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5967
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5967
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5968
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20032

<400>  5968
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagauggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacauggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagccca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca cgaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5969
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4Z9V2

<400>  5969

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5970
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5970
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5971
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5971
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5972
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5972
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5973
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5973
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5974
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5974
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5975
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5975
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5976
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20469

<400>  5976
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggggaaaaa      360

uauuuacaga caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5977
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZB52

<400>  5977

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5978
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5978
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5979
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5979
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5980
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5980
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5981
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5981
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5982
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5982
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5983
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5983
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5984
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW20914

<400>  5984
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaagcac auuagaaaac uguggaaggc uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5985
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZCA2

<400>  5985

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5986
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5986
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5987
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5987
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5988
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5988
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5989
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5989
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5990
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5990
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5991
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5991
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  5992
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21349

<400>  5992
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggguauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  5993
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZCG3

<400>  5993

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  5994
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5994
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  5995
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5995
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  5996
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5996
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  5997
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5997
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  5998
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5998
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  5999
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  5999
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6000
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW21790

<400>  6000
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6001
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZEM2

<400>  6001

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6002
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6002
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6003
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6003
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6004
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6004
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6005
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6005
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6006
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6006
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6007
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6007
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6008
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22218

<400>  6008
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauacgaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugucu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uccaaaaagg aagugcaaca      180

uuacauggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua gugguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6009
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZFD0

<400>  6009

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6010
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6010
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6011
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6011
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6012
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6012
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6013
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6013
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6014
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6014
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6015
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6015
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6016
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW22656

<400>  6016
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugccu aauaaauaau      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaacu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6017
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZGR1

<400>  6017

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Thr Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6018
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6018
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucaccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6019
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6019
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucacgac ccucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacacgac ccucuccccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6020
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6020
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucaccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6021
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6021
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucacuac guuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauaccacac uguauacuac ccuaucaccu ugcgacaugu guacaggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagaguaa aggagagaag      360

uaucuccaga cccgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6022
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6022
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucaccac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6023
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6023
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuacgac ccuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauacaaccc uguauacaac ccuuagcccu ugcgacaugu guacaggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaaguccaa aggagagaag      360

uaucugcaga cccggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6024
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23097

<400>  6024
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaacaac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aaggccacaa gauugguuug aagauauagg agaauaa         477


<210>  6025
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZIM2

<400>  6025

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6026
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6026
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6027
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6027
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6028
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6028
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6029
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6029
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6030
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6030
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6031
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6031
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6032
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23539

<400>  6032
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6033
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZJC0

<400>  6033

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6034
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6034
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6035
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6035
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6036
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6036
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6037
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6037
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6038
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6038
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6039
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6039
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6040
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW23972

<400>  6040
augguaacag gaggaauggc gaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg gagugcaaca      180

uuacacggag aaauaaguac auuagaaaac ugcggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6041
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZK17

<400>  6041

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6042
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6042
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6043
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6043
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6044
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6044
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6045
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6045
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6046
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6046
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6047
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6047
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6048
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24410

<400>  6048
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaac      120

aaagacggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugcgacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6049
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZMC8

<400>  6049

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6050
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6050
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6051
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6051
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6052
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6052
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6053
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6053
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6054
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6054
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6055
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6055
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6056
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW24849

<400>  6056
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggaugccu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6057
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZMX9

<400>  6057

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6058
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6058
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6059
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6059
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6060
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6060
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6061
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6061
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6062
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6062
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6063
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6063
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6064
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25291

<400>  6064
augguaacag gagggauggc aaguaaaugg gaccaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcgaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caaggugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6065
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZP21

<400>  6065

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6066
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6066
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccaauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau ucaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6067
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6067
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6068
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6068
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6069
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6069
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6070
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6070
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6071
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6071
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6072
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25697

<400>  6072
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccgauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagagggcac aauaugaggu uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac acuagaaaau ugugggagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6073
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZQ62

<400>  6073

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6074
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6074
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6075
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6075
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6076
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6076
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6077
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6077
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6078
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6078
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6079
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6079
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6080
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26215

<400>  6080
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggaggg guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagagaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6081
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZQ92

<400>  6081

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6082
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6082
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6083
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6083
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6084
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6084
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6085
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6085
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6086
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6086
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6087
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6087
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6088
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW25948

<400>  6088
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

cuacauggag aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaagucca ugugauaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6089
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZS31

<400>  6089

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6090
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6090
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6091
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6091
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6092
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6092
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6093
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6093
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6094
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6094
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6095
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6095
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6096
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26880

<400>  6096
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauacaa agaaggggga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaagcac auuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uaucuacaaa caaggggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6097
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZS87

<400>  6097

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6098
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6098
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6099
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6099
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6100
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6100
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6101
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6101
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6102
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6102
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6103
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6103
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6104
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW26613

<400>  6104
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagcgcgaca      180

uuacauggag aaauaaguac auuagaaaau ugcggaaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6105
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZTS6

<400>  6105

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6106
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6106
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6107
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6107
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6108
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6108
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6109
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6109
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6110
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6110
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6111
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6111
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6112
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27148

<400>  6112
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6113
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZUK0

<400>  6113

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6114
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6114
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6115
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6115
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6116
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6116
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6117
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6117
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6118
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6118
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6119
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6119
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6120
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27576

<400>  6120
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguacuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac auuagaaaac uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagagaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6121
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZVN6

<400>  6121

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6122
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6122
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6123
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6123
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6124
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6124
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6125
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6125
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6126
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6126
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6127
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6127
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6128
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW27843

<400>  6128
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aagagggcau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaagcac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caaggggaca ugaaguagua guaguagaug augaaaggug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6129
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZWP2

<400>  6129

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6130
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6130
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6131
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6131
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6132
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6132
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6133
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6133
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6134
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6134
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6135
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6135
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6136
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28286

<400>  6136
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcac uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa gcguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacauggag aaauaaguac auuagaaaau uguggaaggu uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac acuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggggaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6137
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__A0A0D4ZX07

<400>  6137

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6138
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6138
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6139
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6139
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6140
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6140
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6141
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6141
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6142
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6142
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6143
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6143
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6144
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AJW28555

<400>  6144
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaagcac auuagaaaac uguggaaggc uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6145
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__Q12178

<400>  6145

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6146
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6146
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg uuccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6147
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6147
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6148
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6148
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6149
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6149
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6150
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6150
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6151
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6151
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6152
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__AAB67713

<400>  6152
augguaacag gaggaauggc aagcaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcgc uaggauauaa agaaggagga guaccaauag gaggaugcuu aauaaauaac      120

aaagacggaa gcguacuagg aagaggacau aauaugagau uccaaaaagg aagugcaaca      180

uuacacggag aaauaagcac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacac uauauacaac auuaucacca ugugacaugu gcacaggagc aauaauaaug      300

uacggaauac caagaugugu aguaggagaa aauguaaauu ucaaaagcaa aggagaaaaa      360

uaucuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagacga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6153
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__W7PK48

<400>  6153

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6154
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6154
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6155
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6155
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6156
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6156
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6157
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6157
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6158
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6158
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6159
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6159
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6160
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWG82851

<400>  6160
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggauau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagauggaa guguauuagg aaggggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacaugggg aaauaaguac auuagaaaau uguggaagau uagaaggaaa aguauauaaa      240

gauacaacgu uauauacaac auuaagucca ugugauaugu guacaggagc aauaauaaug      300

uauggaauac caagaugcgu aguaggagaa aauguaaauu uuaaaaguaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug augaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccacaa gauugguuug aagauauagg agaauaa         477


<210>  6161
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__W7R647

<400>  6161

Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210>  6162
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6162
auggugacag ggggaauggc aagcaagugg gaucagaagg guauggacau ugccuaugag       60

gaggcggccu uagguuacaa agaggguggu guuccuauug gcggaugucu uaucaauaac      120

aaagacggaa guguucucgg ucguggucac aacaugagau uucaaaaggg auccgccaca      180

cuacauggug agaucuccac uuuggaaaac ugugggagau uagagggcaa aguguacaaa      240

gauaccacuu uguauacgac gcugucucca ugcgacaugu guacaggugc caucaucaug      300

uaugguauuc cacgcugugu ugucggugag aacguuaauu ucaaaaguaa gggcgagaaa      360

uauuuacaaa cuagagguca cgagguuguu guuguugacg augagaggug uaaaaagauc      420

augaaacaau uuaucgauga aagaccucag gauugguuug aagauauugg ugaguag         477


<210>  6163
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6163
auggugaccg gcgggauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggcggccc ugggguacaa ggagggcggg guccccaucg gcggcugccu caucaacaac      120

aaggacgggu ccgugcuggg ccgcgggcac aacaugcggu uccagaaggg cagcgccacc      180

cugcacgggg agaucuccac gcucgagaac ugcggccgcc uggagggcaa gguguacaag      240

gacaccaccc uguacaccac gcucagcccg ugcgacaugu gcaccggggc caucaucaug      300

uacggcaucc cccggugcgu cgugggggag aacgugaacu ucaaguccaa gggcgagaag      360

uaccugcaga cccgcggcca cgaggucgug guggucgacg acgagcggug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg ggaguga         477


<210>  6164
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6164
auggucaccg gcggcauggc cuccaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ucggcuacaa ggagggcggc guccccaucg gcggcugccu caucaacaac      120

aaggacggcu ccguccucgg ccgcggccac aacaugcgcu uccagaaggg cuccgccacc      180

cuccacggcg agaucuccac ccucgagaac ugcggccgcc ucgagggcaa ggucuacaag      240

gacaccaccc ucuacaccac ccucuccccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc cccgcugcgu cgucggcgag aacgucaacu ucaaguccaa gggcgagaag      360

uaccuccaga cccgcggcca cgaggucguc gucgucgacg acgagcgcug caagaagauc      420

augaagcagu ucaucgacga gcgcccccag gacugguucg aggacaucgg cgaguga         477


<210>  6165
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6165
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagcagccc uggguuauaa ggagggcggg guccccauug gaggcugccu cauaaacaau      120

aaagacgguu ccguucuugg gagaggacac aacaugaggu uccaaaaggg cucugcgaca      180

cugcauggcg aaaucucaac uuuggagaau ugugggcggu uagaaggaaa aguguacaag      240

gauacgaccc uguauacaac ucuaaguccu ugcgacaugu guaccggugc uauuaucaug      300

uacggcauuc cacgcugcgu agugggggag aacgucaauu uuaagagcaa aggagagaag      360

uaucuccaga cacgaggcca cgaagugguu guggucgaug acgagcguug uaaaaagauc      420

augaaacagu ucauagauga aagaccgcag gacugguuug aggauaucgg ugaguga         477


<210>  6166
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6166
auggugaccg gcggcauggc cagcaagugg gaccagaagg gcauggacau cgccuacgag       60

gaggccgccc ugggcuacaa ggagggcggc gugcccaucg gcggcugccu gaucaacaac      120

aaggacggca gcgugcuggg cagaggccac aacaugagau uccagaaggg cagcgccacc      180

cugcacggcg agaucagcac ccuggagaac ugcggcagac uggagggcaa gguguacaag      240

gacaccaccc uguacaccac ccugagcccc ugcgacaugu gcaccggcgc caucaucaug      300

uacggcaucc ccagaugcgu ggugggcgag aacgugaacu ucaagagcaa gggcgagaag      360

uaccugcaga ccagaggcca cgagguggug gugguggacg acgagagaug caagaagauc      420

augaagcagu ucaucgacga gagaccccag gacugguucg aggacaucgg cgaguga         477


<210>  6167
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6167
auggugaccg gcgggauggc cagcaagugg gaccagaaag gaauggauau cgcuuacgag       60

gaagccgcgc ugggcuauaa ggaaggggga guccccauug gcgggugccu caucaacaau      120

aaagacggau ccguucuggg cagaggccac aacaugcggu uccaaaaggg gucugcuaca      180

cuucauggag agauuagcac gcuggagaau uguggccgcc ucgaagggaa aguguacaag      240

gauaccacac uguauaccac acuuuccccu ugcgacaugu guaccggagc caucauuaug      300

uacggcaucc cgagaugcgu ggucggggag aacgugaauu uuaagucuaa aggagagaag      360

uaucugcaga cacggggcca cgaaguugug gucguggaug acgagcgcug uaaaaagauc      420

augaaacagu ucauugauga aagaccccag gacugguuug aggauaucgg cgaguga         477


<210>  6168
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytosine_Deaminase_fcy1__Saccharomyces_cerevisiae__EWH15533

<400>  6168
augguaacag gaggaauggc aaguaaaugg gaucaaaaag gaauggacau agcauaugaa       60

gaagcagcau uaggauauaa agaaggagga guaccaauag gaggauguuu aauaaauaau      120

aaagacggaa guguauuagg aagaggacau aauaugagau uucaaaaagg aagugcaaca      180

uuacacggag aaauaaguac acuagaaaac uguggaagac uagaaggaaa aguauauaaa      240

gauacaacau uauauacaac auuaagucca ugugacaugu gcacaggagc aauaauaaug      300

uauggaauac caagaugugu aguaggagaa aauguaaauu uuaaaagcaa aggagaaaaa      360

uauuuacaaa caagaggaca ugaaguagua guaguagaug acgaaagaug uaaaaaaaua      420

augaaacaau uuauagauga aagaccgcaa gauugguuug aagauauagg agaauaa         477


<210>  6169
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Deoxy-cytidine_Kinase_dCK__Homo_sapiens__P27707

<400>  6169

Met Ala Thr Pro Pro Lys Arg Ser Cys Pro Ser Phe Ser Ala Ser Ser 
1               5                   10                  15      


Glu Gly Thr Arg Ile Lys Lys Ile Ser Ile Glu Gly Asn Ile Ala Ala 
            20                  25                  30          


Gly Lys Ser Thr Phe Val Asn Ile Leu Lys Gln Leu Cys Glu Asp Trp 
        35                  40                  45              


Glu Val Val Pro Glu Pro Val Ala Arg Trp Cys Asn Val Gln Ser Thr 
    50                  55                  60                  


Gln Asp Glu Phe Glu Glu Leu Thr Met Ser Gln Lys Asn Gly Gly Asn 
65                  70                  75                  80  


Val Leu Gln Met Met Tyr Glu Lys Pro Glu Arg Trp Ser Phe Thr Phe 
                85                  90                  95      


Gln Thr Tyr Ala Cys Leu Ser Arg Ile Arg Ala Gln Leu Ala Ser Leu 
            100                 105                 110         


Asn Gly Lys Leu Lys Asp Ala Glu Lys Pro Val Leu Phe Phe Glu Arg 
        115                 120                 125             


Ser Val Tyr Ser Asp Arg Tyr Ile Phe Ala Ser Asn Leu Tyr Glu Ser 
    130                 135                 140                 


Glu Cys Met Asn Glu Thr Glu Trp Thr Ile Tyr Gln Asp Trp His Asp 
145                 150                 155                 160 


Trp Met Asn Asn Gln Phe Gly Gln Ser Leu Glu Leu Asp Gly Ile Ile 
                165                 170                 175     


Tyr Leu Gln Ala Thr Pro Glu Thr Cys Leu His Arg Ile Tyr Leu Arg 
            180                 185                 190         


Gly Arg Asn Glu Glu Gln Gly Ile Pro Leu Glu Tyr Leu Glu Lys Leu 
        195                 200                 205             


His Tyr Lys His Glu Ser Trp Leu Leu His Arg Thr Leu Lys Thr Asn 
    210                 215                 220                 


Phe Asp Tyr Leu Gln Glu Val Pro Ile Leu Thr Leu Asp Val Asn Glu 
225                 230                 235                 240 


Asp Phe Lys Asp Lys Tyr Glu Ser Leu Val Glu Lys Val Lys Glu Phe 
                245                 250                 255     


Leu Ser Thr Leu 
            260 


<210>  6170
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6170
auggccaccc cgcccaagag aagcugcccg ucuuucucag ccagcucuga ggggacccgc       60

aucaagaaaa ucuccaucga agggaacauc gcugcaggga agucaacauu ugugaauauc      120

cuuaaacaau ugugugaaga uugggaagug guuccugaac cuguugccag auggugcaau      180

guucaaagua cucaagauga auuugaggaa cuuacaaugu cucagaaaaa uggugggaau      240

guucuucaga ugauguauga gaaaccugaa cgauggucuu uuaccuucca aacauaugcc      300

ugucucaguc gaauaagagc ucagcuugcc ucucugaaug gcaagcucaa agaugcagag      360

aaaccuguau uauuuuuuga acgaucugug uauagugaca gguauauuuu ugcaucuaau      420

uuguaugaau cugaaugcau gaaugagaca gaguggacaa uuuaucaaga cuggcaugac      480

uggaugaaua accaauuugg ccaaagccuu gaauuggaug gaaucauuua ucuucaagcc      540

acuccagaga caugcuuaca uagaauauau uuacggggaa gaaaugaaga gcaaggcauu      600

ccucuugaau auuuagagaa gcuucauuau aaacaugaaa gcuggcuccu gcauaggaca      660

cugaaaacca acuucgauua ucuucaagag gugccuaucu uaacacugga uguuaaugaa      720

gacuuuaaag acaaauauga aagucugguu gaaaagguca aagaguuuuu gaguacuuug      780

uga                                                                    783


<210>  6171
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6171
auggccacgc ccccgaagcg cagcugcccc uccuucagcg ccuccagcga gggcacccgg       60

aucaagaaga ucuccaucga ggggaacauc gcggccggca agagcaccuu cgugaacauc      120

cugaagcagc ucugcgagga cugggagguc gugcccgagc ccguggcccg cuggugcaac      180

guccagucca cccaggacga guucgaggag cugaccauga gccagaagaa cgggggcaac      240

gugcugcaga ugauguacga gaagccggag cggugguccu ucaccuucca gacguacgcc      300

ugccucagcc gcauccgggc ccagcuggcg ucccugaacg ggaagcucaa ggacgccgag      360

aagcccgugc uguucuucga gcgcagcguc uacuccgacc gguacaucuu cgccagcaac      420

cuguacgagu ccgagugcau gaacgagacc gaguggacca ucuaccagga cuggcacgac      480

uggaugaaca accaguucgg ccagagccuc gagcuggacg gcaucaucua ccugcaggcc      540

acccccgaga cgugccucca ccgcaucuac cugcgggggc gcaacgagga gcagggcauc      600

ccccuggagu accucgagaa gcugcacuac aagcacgagu ccuggcugcu ccaccggacc      660

cugaagacca acuucgacua ccugcaggag gugccgaucc ucacccugga cgugaacgag      720

gacuucaagg acaaguacga gagccugguc gagaagguga aggaguuccu cuccacgcug      780

uga                                                                    783


<210>  6172
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6172
auggccaccc cccccaagcg cuccugcccc uccuucuccg ccuccuccga gggcacccgc       60

aucaagaaga ucuccaucga gggcaacauc gccgccggca aguccaccuu cgucaacauc      120

cucaagcagc ucugcgagga cugggagguc guccccgagc ccgucgcccg cuggugcaac      180

guccagucca cccaggacga guucgaggag cucaccaugu cccagaagaa cggcggcaac      240

guccuccaga ugauguacga gaagcccgag cgcugguccu ucaccuucca gaccuacgcc      300

ugccucuccc gcauccgcgc ccagcucgcc ucccucaacg gcaagcucaa ggacgccgag      360

aagcccgucc ucuucuucga gcgcuccguc uacuccgacc gcuacaucuu cgccuccaac      420

cucuacgagu ccgagugcau gaacgagacc gaguggacca ucuaccagga cuggcacgac      480

uggaugaaca accaguucgg ccagucccuc gagcucgacg gcaucaucua ccuccaggcc      540

acccccgaga ccugccucca ccgcaucuac cuccgcggcc gcaacgagga gcagggcauc      600

ccccucgagu accucgagaa gcuccacuac aagcacgagu ccuggcuccu ccaccgcacc      660

cucaagacca acuucgacua ccuccaggag guccccaucc ucacccucga cgucaacgag      720

gacuucaagg acaaguacga gucccucguc gagaagguca aggaguuccu cuccacccuc      780

uga                                                                    783


<210>  6173
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6173
auggccacac ccccuaagag aagcugccca uccuucucug cuucaaguga gggcaccagg       60

aucaaaaaga uuagcauaga agggaacauc gcagccggaa aauccacuuu ugugaauauu      120

cugaagcagc ucugugagga cugggaaguc guuccggagc ccguggcgcg guggugcaac      180

guacaaucua cgcaggauga auuugaggag cuuaccaugu cgcagaaaaa ugguggcaac      240

gugcugcaga ugauguacga aaagccugag cgcuggucau ucacauucca aacuuaugcu      300

uguuugagcc gaauccgugc ccaguuagca agucugaaug ggaagcuaaa agacgccgaa      360

aagccagucc ucuuuuucga gagauccgug uacucugaua gguauauuuu ugcuagcaac      420

cuguacgagu ccgaaugcau gaaugagacc gaauggacaa ucuaucagga cuggcacgau      480

uggaugaaca aucaguucgg acaaucacuu gagcuggacg gcauaaucua cuugcaggca      540

acccccgaaa cuugucucca ucggauuuau cugcgcggua gaaacgagga gcaggggauc      600

ccucuggaau accucgagaa auuacacuac aagcaugaaa guuggcugcu ucacaggaca      660

uugaaaacca auuuugauua ucugcaggag guuccaauuc uaacgcucga cgugaacgaa      720

gauuucaagg acaaguacga gagccugguc gagaaaguga aggaauuucu uucuacucug      780

uga                                                                    783


<210>  6174
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6174
auggccaccc cccccaagag aagcugcccc agcuucagcg ccagcagcga gggcaccaga       60

aucaagaaga ucagcaucga gggcaacauc gccgccggca agagcaccuu cgugaacauc      120

cugaagcagc ugugcgagga cugggaggug gugcccgagc ccguggccag auggugcaac      180

gugcagagca cccaggacga guucgaggag cugaccauga gccagaagaa cggcggcaac      240

gugcugcaga ugauguacga gaagcccgag agauggagcu ucaccuucca gaccuacgcc      300

ugccugagca gaaucagagc ccagcuggcc agccugaacg gcaagcugaa ggacgccgag      360

aagcccgugc uguucuucga gagaagcgug uacagcgaca gauacaucuu cgccagcaac      420

cuguacgaga gcgagugcau gaacgagacc gaguggacca ucuaccagga cuggcacgac      480

uggaugaaca accaguucgg ccagagccug gagcuggacg gcaucaucua ccugcaggcc      540

acccccgaga ccugccugca cagaaucuac cugagaggca gaaacgagga gcagggcauc      600

ccccuggagu accuggagaa gcugcacuac aagcacgaga gcuggcugcu gcacagaacc      660

cugaagacca acuucgacua ccugcaggag gugcccaucc ugacccugga cgugaacgag      720

gacuucaagg acaaguacga gagccuggug gagaagguga aggaguuccu gagcacccug      780

uga                                                                    783


<210>  6175
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6175
auggccacac ccccuaagag aagcugcccg uccuucucug cuagcuccga gggcacccgg       60

aucaaaaaga uuucuaucga agggaacauu gccgcgggaa aaagcacguu ugugaauauc      120

cugaagcagc ucugugagga cugggaaguc guucccgagc cuguggcucg cuggugcaac      180

gugcaaucca cccaggauga auuugaggag cugacaaugu cucagaaaaa uggcgggaac      240

guccuucaga ugauguacga aaagcccgag agauggagcu ucaccuucca aacauaugcc      300

ugucuguccc ggauucgcgc ccagcucgcu agccugaaug gaaaacuuaa ggacgccgaa      360

aagccugugc uguuuuucga gagaucuguu uacuccgauc gguauaucuu ugcuagcaac      420

cucuacgagu cugaaugcau gaaugagacc gaauggacaa ucuaucagga cuggcacgau      480

uggaugaaca aucaguucgg ccaaucccug gagcuggacg ggauuaucua ccuccaggcc      540

acccccgaaa cgugucugca ucgcauuuau cuuagaggac ggaacgagga gcagggcauc      600

ccucuggaau accucgagaa acugcacuac aagcaugaaa gcuggcuucu gcaccgcacc      660

cucaaaacaa auuuugauua ucugcaggag gugccgauuc ugacccucga cgucaacgaa      720

gauuucaagg acaaguacga gucucuggug gagaaaguua aggaauuucu uuccacacug      780

uga                                                                    783


<210>  6176
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Deoxy-cytidine_Kinase_dCK__Homo_sapiens__AAA35752

<400>  6176
auggcaacac caccaaaaag aagcugccca ucauucucag caucaucaga aggcacaaga       60

auaaaaaaaa uaaguauaga aggaaauaua gcagcaggaa aaucaacauu cguaaacaua      120

cuaaaacaau uaugcgaaga cugggaagua guaccagaac caguagcaag auggugcaac      180

guacaaucaa cacaagauga auucgaagaa cuaacaauga gccaaaaaaa cggaggaaac      240

guccuacaaa ugauguacga aaaaccagaa agauggucau ucacauucca aacauacgca      300

ugccuaucaa gaauaagagc acaacuagca ucccuaaacg gaaaacuaaa agacgccgaa      360

aaaccaguac uauucuucga aagaucagua uacagcgaca gauacauauu cgcaucaaac      420

uuauaugaaa gcgaaugcau gaaugaaaca gaauggacaa uauaccaaga uuggcacgac      480

uggaugaaua accaauucgg acaaucacua gaauuagaug gaauaauaua uuuacaagca      540

acaccagaaa caugucuaca cagaauauac cuaagaggaa gaaacgaaga acaaggaaua      600

ccacuagaau acuuagaaaa auuacacuac aaacacgaau cauggcuauu acacagaaca      660

cuaaaaacaa auuucgauua ccuacaagaa guaccaauac uaacacuaga cguaaacgaa      720

gacuucaaag acaaauacga aucacuagua gaaaaaguaa aagaauucuu aucaacacua      780

uaa                                                                    783


<210>  6177
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__Q540Z9

<400>  6177

Met Ala Glu Ala Ala Ser Cys Ala Arg Lys Gly Thr Lys Tyr Ala Glu 
1               5                   10                  15      


Gly Thr Gln Pro Phe Thr Val Leu Ile Glu Gly Asn Ile Gly Ser Gly 
            20                  25                  30          


Lys Thr Thr Tyr Leu Asn His Phe Glu Lys Tyr Lys Asn Asp Ile Cys 
        35                  40                  45              


Leu Leu Thr Glu Pro Val Glu Lys Trp Arg Asn Val Asn Gly Val Asn 
    50                  55                  60                  


Leu Leu Glu Leu Met Tyr Lys Asp Pro Lys Lys Trp Ala Met Pro Phe 
65                  70                  75                  80  


Gln Ser Tyr Val Thr Leu Thr Met Leu Gln Ser His Thr Ala Pro Thr 
                85                  90                  95      


Asn Lys Lys Leu Lys Ile Met Glu Arg Ser Ile Phe Ser Ala Arg Tyr 
            100                 105                 110         


Cys Phe Val Glu Asn Met Arg Arg Asn Gly Ser Leu Glu Gln Gly Met 
        115                 120                 125             


Tyr Asn Thr Leu Glu Glu Trp Tyr Lys Phe Ile Glu Glu Ser Ile His 
    130                 135                 140                 


Val Gln Ala Asp Leu Ile Ile Tyr Leu Arg Thr Ser Pro Glu Val Ala 
145                 150                 155                 160 


Tyr Glu Arg Ile Arg Gln Arg Ala Arg Ser Glu Glu Ser Cys Val Pro 
                165                 170                 175     


Leu Lys Tyr Leu Gln Glu Leu His Glu Leu His Glu Asp Trp Leu Ile 
            180                 185                 190         


His Gln Arg Arg Pro Gln Ser Cys Lys Val Leu Val Leu Asp Ala Asp 
        195                 200                 205             


Leu Asn Leu Glu Asn Ile Gly Thr Glu Tyr Gln Arg Ser Glu Ser Ser 
    210                 215                 220                 


Ile Phe Asp Ala Ile Ser Ser Asn Gln Gln Pro Ser Pro Val Leu Val 
225                 230                 235                 240 


Ser Pro Ser Lys Arg Gln Arg Val Ala Arg 
                245                 250 


<210>  6178
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6178
auggcggagg cagcauccug ugcccgaaag gggaccaagu acgccgaggg cacccagccc       60

uucaccgucc ucaucgaggg caacaucggc agcgggaaga ccacguauuu gaaccacuuc      120

gagaaguaca agaacgacau uugccugcug accgagcccg ucgagaagug gcgcaacguc      180

aacgggguaa aucugcugga gcugauguac aaagauccca agaagugggc caugcccuuu      240

cagaguuaug ucacgcugac caugcugcag ucgcacaccg ccccaaccaa caagaagcua      300

aaaauaaugg agcgcuccau uuuuagcgcu cgcuauugcu ucguggagaa caugcgacga      360

aacggcucgc uggagcaggg cauguacaau acgcuggagg agugguacaa guucaucgaa      420

gaguccauuc acgugcaggc ggaccucauc auauaucugc gcaccucgcc ggagguggcg      480

uacgaacgca uccggcagcg ggcucguucu gaggagagcu gcgugccgcu uaaguaccuu      540

caggagcugc augaguugca cgaggacugg uugauacacc agagacgacc gcagucgugc      600

aagguccuag uccucgaugc cgaucugaac cuggaaaaca uuggcaccga guaccagcgc      660

ucggagagca gcauauucga cgccaucuca aguaaccaac agcccucgcc gguucuggug      720

ucgcccagca agcgccagag ggucgccaga uaa                                   753


<210>  6179
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6179
auggccgagg ccgcgagcug cgcccgcaag ggcaccaagu acgccgaggg gacccagccc       60

uucacggugc ugaucgaggg caacaucggg uccggcaaga ccaccuaccu caaccacuuc      120

gagaaguaca agaacgacau cugccugcug accgagccgg ucgagaagug gcggaacgug      180

aacgggguga accuccugga gcugauguac aaggacccca agaagugggc caugcccuuc      240

cagagcuacg ucacgcucac caugcugcag ucccacaccg cccccaccaa caagaagcug      300

aagaucaugg agcgcagcau cuucuccgcg cgguacugcu ucguggagaa caugcgccgg      360

aacggcagcc ucgagcaggg cauguacaac acgcuggagg agugguacaa guucaucgag      420

gaguccaucc acgugcaggc cgaccugauc aucuaccucc gcaccagccc ggaggucgcc      480

uacgagcgga uccgccagcg ggcccgcucc gaggagagcu gcgugccccu gaaguaccug      540

caggagcucc acgagcugca cgaggacugg cugauccacc agcggcgccc ccaguccugc      600

aaggugcucg uccuggacgc ggaccugaac cucgagaaca ucgggaccga guaccagcgg      660

agcgagucca gcaucuucga cgccaucucc agcaaccagc agcccucccc ggugcuggug      720

agccccucca agcgccagcg ggucgcccgc uga                                   753


<210>  6180
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6180
auggccgagg ccgccuccug cgcccgcaag ggcaccaagu acgccgaggg cacccagccc       60

uucaccgucc ucaucgaggg caacaucggc uccggcaaga ccaccuaccu caaccacuuc      120

gagaaguaca agaacgacau cugccuccuc accgagcccg ucgagaagug gcgcaacguc      180

aacggcguca accuccucga gcucauguac aaggacccca agaagugggc caugcccuuc      240

caguccuacg ucacccucac caugcuccag ucccacaccg cccccaccaa caagaagcuc      300

aagaucaugg agcgcuccau cuucuccgcc cgcuacugcu ucgucgagaa caugcgccgc      360

aacggcuccc ucgagcaggg cauguacaac acccucgagg agugguacaa guucaucgag      420

gaguccaucc acguccaggc cgaccucauc aucuaccucc gcaccucccc cgaggucgcc      480

uacgagcgca uccgccagcg cgcccgcucc gaggaguccu gcgucccccu caaguaccuc      540

caggagcucc acgagcucca cgaggacugg cucauccacc agcgccgccc ccaguccugc      600

aagguccucg uccucgacgc cgaccucaac cucgagaaca ucggcaccga guaccagcgc      660

uccgaguccu ccaucuucga cgccaucucc uccaaccagc agcccucccc cguccucguc      720

ucccccucca agcgccagcg cgucgcccgc uga                                   753


<210>  6181
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6181
auggccgagg cugcaagcug cgccagaaag ggcaccaaau acgcggaagg gacacagccc       60

uucacugugc ugaucgaggg aaacauuggu uccggcaaga cgaccuaucu caaucacuuu      120

gaaaaauaca agaacgacau augucuucug acagagccug ucgaaaaaug gaggaauguu      180

aacgggguga auuuguuaga gcugauguau aaggauccaa agaaaugggc uaugccguuc      240

caaucuuacg uaacucuaac caugcuccag ucacauacag cccccaccaa caagaaacug      300

aagaucaugg agcggaguau uuuuagcgca cgcuauugcu ucguggaaaa uaugcgacgu      360

aacggauccc uugagcaggg cauguacaau acucuggaag agugguauaa auuuaucgag      420

gaaucuauuc acguccaggc cgacuugauc auauaccuca gaacaucgcc ugagguggcu      480

uacgaaagga uccggcaacg cgcaagauca gaggaaagcu guguuccacu gaaguaucug      540

caggagcucc augaguuaca cgaagauugg cugauucauc agaggcggcc ccagaguugc      600

aaggugcuug ucuuggacgc cgaucugaac cuagagaaua ucgguaccga auaccaacgc      660

uccgagucua gcauuuucga cgcuaucucc ucaaaccagc agccuagucc agugcucgua      720

agccccucua aacgacagag aguugccagg uga                                   753


<210>  6182
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6182
auggccgagg ccgccagcug cgccagaaag ggcaccaagu acgccgaggg cacccagccc       60

uucaccgugc ugaucgaggg caacaucggc agcggcaaga ccaccuaccu gaaccacuuc      120

gagaaguaca agaacgacau cugccugcug accgagcccg uggagaagug gagaaacgug      180

aacggcguga accugcugga gcugauguac aaggacccca agaagugggc caugcccuuc      240

cagagcuacg ugacccugac caugcugcag agccacaccg cccccaccaa caagaagcug      300

aagaucaugg agagaagcau cuucagcgcc agauacugcu ucguggagaa caugagaaga      360

aacggcagcc uggagcaggg cauguacaac acccuggagg agugguacaa guucaucgag      420

gagagcaucc acgugcaggc cgaccugauc aucuaccuga gaaccagccc cgagguggcc      480

uacgagagaa ucagacagag agccagaagc gaggagagcu gcgugccccu gaaguaccug      540

caggagcugc acgagcugca cgaggacugg cugauccacc agagaagacc ccagagcugc      600

aaggugcugg ugcuggacgc cgaccugaac cuggagaaca ucggcaccga guaccagaga      660

agcgagagca gcaucuucga cgccaucagc agcaaccagc agcccagccc cgugcuggug      720

agccccagca agagacagag aguggccaga uga                                   753


<210>  6183
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6183
auggccgagg cugccagcug cgcgagaaag ggcaccaaau acgcugaagg gacacagccc       60

uucacggugc ugaucgaggg aaacauuggc uccgggaaga ccacauaucu caaucacuuu      120

gaaaaauaca agaacgacau cugucugcuu accgagccug ucgaaaaaug gcggaauguu      180

aacggaguga aucugcucga gcugauguau aaggauccga agaaaugggc caugcccuuc      240

caaucuuacg ugacacuuac caugcugcag agccauacag ccccuaccaa caagaaacuc      300

aagauuaugg agcgcuccau cuuuucugcu agauauugcu ucgucgaaaa uaugcggcgc      360

aacggcagcc uggagcaggg gauguacaau acgcuggaag agugguauaa auuuauugag      420

gaauccaucc acgugcaggc cgaccucauc auuuaccuga gaaccucucc cgagguugcu      480

uacgaacgga uccgccaaag agcccggagc gaggaauccu gugugccucu uaaguaucug      540

caggagcucc augagcugca cgaagauugg cuuauucauc agcgcagacc ccagagcugc      600

aagguccugg ugcucgacgc ggaucugaac cuggagaaua ucggaacaga auaccaacgg      660

ucugagucca gcauuuucga cgccaucucu uccaaccagc agccuagccc gguucucgug      720

ucucccucca aacgccagag agucgcucgg uga                                   753


<210>  6184
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAM27518

<400>  6184
auggcagaag cagcaucaug cgcaagaaaa ggaacaaaau acgcagaagg cacacaacca       60

uucacaguau uaauagaagg aaacauagga ucaggaaaaa caacauaccu aaaccauuuc      120

gaaaaauaca aaaacgacau augccuacua accgaaccag uagaaaaaug gagaaacgua      180

aacggaguaa accuacuaga acuaauguac aaagacccaa aaaaaugggc aaugccauuc      240

caaucauacg ucacacuaac aauguuacaa ucacacaccg ccccaacaaa caaaaaauua      300

aaaauaaugg aaagaucaau auucagcgca agauacugcu uuguagaaaa caugagaaga      360

aacggaucac uugaacaagg cauguauaac acacuagaag aaugguacaa auucaucgaa      420

gaaucaauac auguccaagc cgaccuaaua auauauuuaa gaaccucacc agaaguagca      480

uacgaaagaa uaagacaaag agcaagaucu gaagaaagcu gcguaccauu aaaauaccua      540

caagaacuac acgaauuaca cgaagacugg cuaauacacc aaagaagacc acaaucaugu      600

aaaguacuag uacuagacgc agacuuaaac cuagaaaaca uaggaacaga auaccaaaga      660

ucagaaucau caauauucga cgcaauauca ucaaaccaac aaccaucacc aguacuagua      720

ucaccaucaa aaagacaaag agucgccaga uaa                                   753


<210>  6185
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__Q9XZT6

<400>  6185

Met Ala Glu Ala Ala Ser Cys Ala Arg Lys Gly Thr Lys Tyr Ala Glu 
1               5                   10                  15      


Gly Thr Gln Pro Phe Thr Val Leu Ile Glu Gly Asn Ile Gly Ser Gly 
            20                  25                  30          


Lys Thr Thr Tyr Leu Asn His Phe Glu Lys Tyr Lys Asn Asp Ile Cys 
        35                  40                  45              


Leu Leu Thr Glu Pro Val Glu Lys Trp Arg Asn Val Asn Gly Val Asn 
    50                  55                  60                  


Leu Leu Glu Leu Met Tyr Lys Asp Pro Lys Lys Trp Ala Met Pro Phe 
65                  70                  75                  80  


Gln Ser Tyr Val Thr Leu Thr Met Leu Gln Ser His Thr Ala Pro Thr 
                85                  90                  95      


Asn Lys Lys Leu Lys Ile Met Glu Arg Ser Ile Phe Ser Ala Arg Tyr 
            100                 105                 110         


Cys Phe Val Glu Asn Met Arg Arg Asn Gly Ser Leu Glu Gln Gly Met 
        115                 120                 125             


Tyr Asn Thr Leu Glu Glu Trp Tyr Lys Phe Ile Glu Glu Ser Ile His 
    130                 135                 140                 


Val Gln Ala Asp Leu Ile Ile Tyr Leu Arg Thr Ser Pro Glu Val Ala 
145                 150                 155                 160 


Tyr Glu Arg Ile Arg Gln Arg Ala Arg Ser Glu Glu Ser Cys Val Pro 
                165                 170                 175     


Leu Lys Tyr Leu Gln Glu Leu His Glu Leu His Glu Asp Trp Leu Ile 
            180                 185                 190         


His Gln Arg Arg Pro Gln Ser Cys Lys Val Leu Val Leu Asp Ala Asp 
        195                 200                 205             


Leu Asn Leu Glu Asn Ile Gly Thr Glu Tyr Gln Arg Ser Glu Ser Ser 
    210                 215                 220                 


Ile Phe Asp Ala Ile Ser Ser Asn Gln Gln Pro Ser Pro Val Leu Val 
225                 230                 235                 240 


Ser Pro Ser Lys Arg Gln Arg Val Ala Arg 
                245                 250 


<210>  6186
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6186
auggcggagg cagcauccug ugcccgaaag gggaccaagu acgccgaggg cacccagccc       60

uucaccgucc ucaucgaggg caacaucggc agcgggaaga ccacguauuu gaaccacuuc      120

gagaaguaca agaacgacau uugccugcug accgagcccg ucgagaagug gcgcaacguc      180

aacgggguaa aucugcugga gcugauguac aaagauccca agaagugggc caugcccuuu      240

cagaguuaug ucacgcugac caugcugcag ucgcacaccg ccccaaccaa caagaagcua      300

aaaauaaugg agcgcuccau uuuuagcgcu cgcuauugcu ucguggagaa caugcgacga      360

aacggcucgc uggagcaggg cauguacaau acgcuggagg agugguacaa guucaucgaa      420

gaguccauuc acgugcaggc ggaccucauc auauaucugc gcaccucgcc ggagguggcg      480

uacgaacgca uccggcagcg ggcucguucu gaggagagcu gcgugccgcu uaaguaccuu      540

caggagcugc augaguugca cgaggacugg uugauacacc agagacgacc gcagucgugc      600

aagguccuag uccucgaugc cgaucugaac cuggaaaaca uuggcaccga guaccagcgc      660

ucggagagca gcauauucga cgccaucuca aguaaccaac agcccucgcc gguucuggug      720

ucgcccagca agcgccagag ggucgccaga uaa                                   753


<210>  6187
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6187
auggccgagg ccgcgagcug cgcccgcaag ggcaccaagu acgccgaggg gacccagccc       60

uucacggugc ugaucgaggg caacaucggg uccggcaaga ccaccuaccu caaccacuuc      120

gagaaguaca agaacgacau cugccugcug accgagccgg ucgagaagug gcggaacgug      180

aacgggguga accuccugga gcugauguac aaggacccca agaagugggc caugcccuuc      240

cagagcuacg ucacgcucac caugcugcag ucccacaccg cccccaccaa caagaagcug      300

aagaucaugg agcgcagcau cuucuccgcg cgguacugcu ucguggagaa caugcgccgg      360

aacggcagcc ucgagcaggg cauguacaac acgcuggagg agugguacaa guucaucgag      420

gaguccaucc acgugcaggc cgaccugauc aucuaccucc gcaccagccc ggaggucgcc      480

uacgagcgga uccgccagcg ggcccgcucc gaggagagcu gcgugccccu gaaguaccug      540

caggagcucc acgagcugca cgaggacugg cugauccacc agcggcgccc ccaguccugc      600

aaggugcucg uccuggacgc ggaccugaac cucgagaaca ucgggaccga guaccagcgg      660

agcgagucca gcaucuucga cgccaucucc agcaaccagc agcccucccc ggugcuggug      720

agccccucca agcgccagcg ggucgcccgc uga                                   753


<210>  6188
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6188
auggccgagg ccgccuccug cgcccgcaag ggcaccaagu acgccgaggg cacccagccc       60

uucaccgucc ucaucgaggg caacaucggc uccggcaaga ccaccuaccu caaccacuuc      120

gagaaguaca agaacgacau cugccuccuc accgagcccg ucgagaagug gcgcaacguc      180

aacggcguca accuccucga gcucauguac aaggacccca agaagugggc caugcccuuc      240

caguccuacg ucacccucac caugcuccag ucccacaccg cccccaccaa caagaagcuc      300

aagaucaugg agcgcuccau cuucuccgcc cgcuacugcu ucgucgagaa caugcgccgc      360

aacggcuccc ucgagcaggg cauguacaac acccucgagg agugguacaa guucaucgag      420

gaguccaucc acguccaggc cgaccucauc aucuaccucc gcaccucccc cgaggucgcc      480

uacgagcgca uccgccagcg cgcccgcucc gaggaguccu gcgucccccu caaguaccuc      540

caggagcucc acgagcucca cgaggacugg cucauccacc agcgccgccc ccaguccugc      600

aagguccucg uccucgacgc cgaccucaac cucgagaaca ucggcaccga guaccagcgc      660

uccgaguccu ccaucuucga cgccaucucc uccaaccagc agcccucccc cguccucguc      720

ucccccucca agcgccagcg cgucgcccgc uga                                   753


<210>  6189
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6189
auggccgagg cugcaagcug cgccagaaag ggcaccaaau acgcggaagg gacacagccc       60

uucacugugc ugaucgaggg aaacauuggu uccggcaaga cgaccuaucu caaucacuuu      120

gaaaaauaca agaacgacau augucuucug acagagccug ucgaaaaaug gaggaauguu      180

aacgggguga auuuguuaga gcugauguau aaggauccaa agaaaugggc uaugccguuc      240

caaucuuacg uaacucuaac caugcuccag ucacauacag cccccaccaa caagaaacug      300

aagaucaugg agcggaguau uuuuagcgca cgcuauugcu ucguggaaaa uaugcgacgu      360

aacggauccc uugagcaggg cauguacaau acucuggaag agugguauaa auuuaucgag      420

gaaucuauuc acguccaggc cgacuugauc auauaccuca gaacaucgcc ugagguggcu      480

uacgaaagga uccggcaacg cgcaagauca gaggaaagcu guguuccacu gaaguaucug      540

caggagcucc augaguuaca cgaagauugg cugauucauc agaggcggcc ccagaguugc      600

aaggugcuug ucuuggacgc cgaucugaac cuagagaaua ucgguaccga auaccaacgc      660

uccgagucua gcauuuucga cgcuaucucc ucaaaccagc agccuagucc agugcucgua      720

agccccucua aacgacagag aguugccagg uga                                   753


<210>  6190
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6190
auggccgagg ccgccagcug cgccagaaag ggcaccaagu acgccgaggg cacccagccc       60

uucaccgugc ugaucgaggg caacaucggc agcggcaaga ccaccuaccu gaaccacuuc      120

gagaaguaca agaacgacau cugccugcug accgagcccg uggagaagug gagaaacgug      180

aacggcguga accugcugga gcugauguac aaggacccca agaagugggc caugcccuuc      240

cagagcuacg ugacccugac caugcugcag agccacaccg cccccaccaa caagaagcug      300

aagaucaugg agagaagcau cuucagcgcc agauacugcu ucguggagaa caugagaaga      360

aacggcagcc uggagcaggg cauguacaac acccuggagg agugguacaa guucaucgag      420

gagagcaucc acgugcaggc cgaccugauc aucuaccuga gaaccagccc cgagguggcc      480

uacgagagaa ucagacagag agccagaagc gaggagagcu gcgugccccu gaaguaccug      540

caggagcugc acgagcugca cgaggacugg cugauccacc agagaagacc ccagagcugc      600

aaggugcugg ugcuggacgc cgaccugaac cuggagaaca ucggcaccga guaccagaga      660

agcgagagca gcaucuucga cgccaucagc agcaaccagc agcccagccc cgugcuggug      720

agccccagca agagacagag aguggccaga uga                                   753


<210>  6191
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6191
auggccgagg cugccagcug cgcgagaaag ggcaccaaau acgcugaagg gacacagccc       60

uucacggugc ugaucgaggg aaacauuggc uccgggaaga ccacauaucu caaucacuuu      120

gaaaaauaca agaacgacau cugucugcuu accgagccug ucgaaaaaug gcggaauguu      180

aacggaguga aucugcucga gcugauguau aaggauccga agaaaugggc caugcccuuc      240

caaucuuacg ugacacuuac caugcugcag agccauacag ccccuaccaa caagaaacuc      300

aagauuaugg agcgcuccau cuuuucugcu agauauugcu ucgucgaaaa uaugcggcgc      360

aacggcagcc uggagcaggg gauguacaau acgcuggaag agugguauaa auuuauugag      420

gaauccaucc acgugcaggc cgaccucauc auuuaccuga gaaccucucc cgagguugcu      480

uacgaacgga uccgccaaag agcccggagc gaggaauccu gugugccucu uaaguaucug      540

caggagcucc augagcugca cgaagauugg cuuauucauc agcgcagacc ccagagcugc      600

aagguccugg ugcucgacgc ggaucugaac cuggagaaua ucggaacaga auaccaacgg      660

ucugagucca gcauuuucga cgccaucucu uccaaccagc agccuagccc gguucucgug      720

ucucccucca aacgccagag agucgcucgg uga                                   753


<210>  6192
<211>  753
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Deoxynucleoside_Kinase_dNK__Drosophila_melanogaster__AAD47355

<400>  6192
auggcagaag cagcaucaug cgcaagaaaa ggaacuaaau acgcagaagg cacacaacca       60

uucacaguau uaauagaagg aaacauagga agcggaaaaa caacauacuu aaaccacuuc      120

gaaaaauaua aaaacgacau augccuacua acugaaccag uagaaaaaug gagaaacgua      180

aacggaguaa acuuacuaga acuaauguac aaagacccua aaaaaugggc aaugccauuc      240

caaucauacg uaacacuaac aaugcuacaa ucacauacag caccaacaaa caaaaaacua      300

aaaauaaugg aaagaaguau auucucagca agauauugcu ucguagaaaa caugagaaga      360

aacggaagcc uagaacaagg aauguacaac acauuagaag aaugguacaa auucauagaa      420

gaaucaauac acguacaagc cgaccuaaua auauaccuaa gaacaucacc agaaguagca      480

uacgaaagaa uaagacaaag agcaagaagc gaagaaagcu gcguaccauu aaaauaccua      540

caagaacuac acgaacuaca cgaagacugg cuaauacacc aaagaagacc acaaaguugc      600

aaaguauuag uauuagacgc agaccuaaau cuagaaaaca uaggaacaga auaucaaaga      660

ucagaaucaa guauauucga cgcaauauca ucaaaccaac aaccaucacc aguacuagua      720

ucacccucaa aaagacaaag aguagcaaga uaa                                   753


<210>  6193
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A023Z7B9

<400>  6193

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6194
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6194
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6195
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6195
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6196
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6196
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6197
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6197
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6198
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6198
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6199
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6199
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6200
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHY74112

<400>  6200
auggcaacac cacauauaaa ugcagaaaug ggggacuuug cagauguagu acuaaugcca       60

ggggacccau uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaaccuaua aagggagaaa aauaucagua      180

augggacaug gaaugggcau uccaaguugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucauguggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuuugaua ugguacgaaa ugccguagac      420

gcagccaaag cauuaggaau agacgcaaga gugggaaauc uuuuuagcgc agacuuauuu      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagggauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguaccguaa gcgaccacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac uauuaggaga caaagaauaa      720


<210>  6201
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A024KMI2

<400>  6201

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6202
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6202
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggugu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6203
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6203
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6204
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6204
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6205
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6205
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6206
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6206
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6207
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6207
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6208
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDU33019

<400>  6208
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auauauagca gaaacauucc ucgaagacgc aagagaagua      120

aauaacguaa gagggauguu aggauuuaca gggacauaua aaggaagaaa aauaagugua      180

augggacaug guaugggaau accaucaugc aguauauaua ccaaagaauu aauaacggac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcgggg ccguacuacc acaugugaaa      300

uuaagagaug uaguaauagg aaugggggca uguacagaca guaaaguaaa uaggauaaga      360

uuuaaagauc acgauuucgc agcaauagca gacuucgaua ugguaagaaa ugcaguugac      420

gcagcaaaag cauuaggagu agacgcaaga gugggaaauc uauucagugc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguggaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc guuaacaaua      600

uguacgguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug auaugauaaa aauagcauua gaaaguguac uauuaggaga uaaagaauga      720


<210>  6209
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E0SRY5

<400>  6209

Met Thr Ala His Ile Asn Ala Lys Leu Gly Asp Phe Ala Pro Thr Val 
1               5                   10                  15      


Ile Met Pro Gly Asp Pro Leu Arg Ala Lys Phe Ile Ala Glu Asn Tyr 
            20                  25                  30          


Leu Gln Asp His Arg Glu Val Thr Asn Val Arg Asn Met Leu Gly Tyr 
        35                  40                  45              


Thr Gly Phe Tyr Ser Gly Gln Leu Ile Ser Val Met Gly His Gly Met 
    50                  55                  60                  


Gly Ile Pro Ser Met Thr Leu Tyr Ala His Glu Leu Val Asn Asp Phe 
65                  70                  75                  80  


Asp Val Lys Arg Ile Ile Arg Val Gly Ser Leu Gly Ala Thr Gln Arg 
                85                  90                  95      


Thr Ile Lys Met Arg Asp Ile Ile Leu Ala Val Ala Ser Gly Thr Asp 
            100                 105                 110         


Ser Val Thr Asn Phe Lys Arg Ser Ser Gly Tyr Phe Met Ala Ser Ser 
        115                 120                 125             


Ala Tyr Phe Pro Leu Leu Gln Lys Ala Trp Ser Leu Ala Gln Glu Ala 
    130                 135                 140                 


Gly Leu Glu Val Lys Ala Gly Asn Val Phe Ser Gly Asp Ile Tyr Tyr 
145                 150                 155                 160 


Asp Pro Asp Asp Asn Leu Ile Pro Ala Leu Glu Lys Phe Gly Val Leu 
                165                 170                 175     


Gly Ile Asp Met Glu Val Ala Gly Leu Tyr Ala Leu Ala His Gln Phe 
            180                 185                 190         


Gly Ile Glu Ala Leu Ala Ile Leu Thr Val Ser Asp His Cys Leu Thr 
        195                 200                 205             


Gly Glu Glu Thr Thr Ala Glu Glu Arg Gln Leu Thr Phe Asn Asn Met 
    210                 215                 220                 


Ile Glu Leu Ala Leu Asn Thr Ala Val Ala Ile 
225                 230                 235 


<210>  6210
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6210
augacugcac auauaaaugc uaaacuaggc gauuuugcac caacaguaau uaugccagga       60

gauccucuaa gggcgaaauu uauagccgaa aacuaucugc aggaccaccg ugaagucaca      120

aauguucgga auauguuggg auacacggga uucuauucag ggcaacucau uucugugaug      180

gggcacggaa ugggaauucc aucaaugaca uuauaugccc augaacuggu uaaugauuuu      240

gauguaaaac ggauuauucg uguuggcagu cuuggugcaa cacaacguac aauuaaaaug      300

cgggauauua uuuuagcggu cgcuuccgga acagacucug ucacuaauuu uaaacguagu      360

ucggguuacu uuauggcguc cuccgcauau uuccccuuau uacaaaaagc auggucauua      420

gcucaggaag ccgguuuaga gguaaaagcu ggcaauguau uuagcggcga cauuuauuac      480

gauccggaug auaauuuaau uccggcacuu gagaaauucg gagugcuagg uaucgauaug      540

gaagucgcag gguuauaugc acuugcacau caauucggua uugaagcguu ggcaauuuua      600

acgguauccg aucacugucu gacaggagaa gaaacaacag cagaagagcg acaguuaaca      660

uuuaacaaca ugauugaauu ggcgcugaau acugcugucg ccauuuag                   708


<210>  6211
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6211
augaccgccc acaucaacgc caagcugggc gacuucgcgc ccaccgugau caugccgggg       60

gacccccucc gcgccaaguu caucgccgag aacuaccugc aggaccaccg ggaggucacg      120

aacgugcgca acaugcuggg cuacaccggg uucuacagcg gccagcucau cuccgugaug      180

gggcacggca ugggcauccc cagcaugacc cuguacgccc acgagcuggu caacgacuuc      240

gacgugaagc ggaucauccg cguggggucc cucggcgcca cccagcggac gaucaagaug      300

cgcgacauca uccuggcggu cgccagcggg accgacuccg ugaccaacuu caagcggagc      360

uccggcuacu ucauggccag cuccgccuac uucccccugc uccagaaggc guggagccug      420

gcccaggagg ccgggcugga ggugaaggcc ggcaacgucu ucuccggcga caucuacuac      480

gacccggacg acaaccucau ccccgcccug gagaaguucg gggugcuggg caucgacaug      540

gagguggcgg ggcucuacgc ccuggcccac caguucggca ucgaggcccu ggccauccuc      600

accgucagcg accacugccu gacgggcgag gagaccaccg cggaggagcg ccagcugacc      660

uucaacaaca ugaucgagcu cgcccugaac acggccgugg ccaucuga                   708


<210>  6212
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6212
augaccgccc acaucaacgc caagcucggc gacuucgccc ccaccgucau caugcccggc       60

gacccccucc gcgccaaguu caucgccgag aacuaccucc aggaccaccg cgaggucacc      120

aacguccgca acaugcucgg cuacaccggc uucuacuccg gccagcucau cuccgucaug      180

ggccacggca ugggcauccc cuccaugacc cucuacgccc acgagcucgu caacgacuuc      240

gacgucaagc gcaucauccg cgucggcucc cucggcgcca cccagcgcac caucaagaug      300

cgcgacauca uccucgccgu cgccuccggc accgacuccg ucaccaacuu caagcgcucc      360

uccggcuacu ucauggccuc cuccgccuac uucccccucc uccagaaggc cuggucccuc      420

gcccaggagg ccggccucga ggucaaggcc ggcaacgucu ucuccggcga caucuacuac      480

gaccccgacg acaaccucau ccccgcccuc gagaaguucg gcguccucgg caucgacaug      540

gaggucgccg gccucuacgc ccucgcccac caguucggca ucgaggcccu cgccauccuc      600

accgucuccg accacugccu caccggcgag gagaccaccg ccgaggagcg ccagcucacc      660

uucaacaaca ugaucgagcu cgcccucaac accgccgucg ccaucuga                   708


<210>  6213
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6213
augaccgccc acaucaacgc uaagcugggc gacuucgcac ccacagugau uaugccuggg       60

gauccacuca gagccaaauu uauagcggag aauuaccuuc aggaccauag ggaagucacu      120

aacguucgga auaugcuggg auauacgggu uucuacagcg gccaauugau cuccgugaug      180

gggcacggaa ugggcauucc gucuaugacc uuauaugcuc augagcuggu aaacgauuuu      240

gacgugaagc gcaucauucg agucgguuca cuaggggcca cacagcguac uaucaaaaug      300

agagauauaa uccucgcagu ggccagugga accgacagcg uuacaaauuu caagaggucc      360

ucuggcuacu uuauggcuuc gucagcauau uucccccugc uucagaaagc cuggagccug      420

gcucaggaag ccggcuugga ggugaaggcg gggaacgucu uuaguggaga uauuuacuau      480

gacccugaug acaaucucau cccagcacug gaaaaguucg gugugcuggg cauugauaug      540

gagguagccg ggcucuacgc uuuagcccac caauuuggaa ucgaggcacu ggcuauacuu      600

accguuuccg accauugcuu gacuggcgaa gagacaaccg ccgaggaacg gcagcugacg      660

uucaacaaua ugauugagcu agcgcucaac acugccgugg caaucuga                   708


<210>  6214
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6214
augaccgccc acaucaacgc caagcugggc gacuucgccc ccaccgugau caugcccggc       60

gacccccuga gagccaaguu caucgccgag aacuaccugc aggaccacag agaggugacc      120

aacgugagaa acaugcuggg cuacaccggc uucuacagcg gccagcugau cagcgugaug      180

ggccacggca ugggcauccc cagcaugacc cuguacgccc acgagcuggu gaacgacuuc      240

gacgugaaga gaaucaucag agugggcagc cugggcgcca cccagagaac caucaagaug      300

agagacauca uccuggccgu ggccagcggc accgacagcg ugaccaacuu caagagaagc      360

agcggcuacu ucauggccag cagcgccuac uucccccugc ugcagaaggc cuggagccug      420

gcccaggagg ccggccugga ggugaaggcc ggcaacgugu ucagcggcga caucuacuac      480

gaccccgacg acaaccugau ccccgcccug gagaaguucg gcgugcuggg caucgacaug      540

gagguggccg gccuguacgc ccuggcccac caguucggca ucgaggcccu ggccauccug      600

accgugagcg accacugccu gaccggcgag gagaccaccg ccgaggagag acagcugacc      660

uucaacaaca ugaucgagcu ggcccugaac accgccgugg ccaucuga                   708


<210>  6215
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6215
augaccgccc acaucaacgc uaagcugggc gacuucgccc ccacagugau uaugccuggg       60

gauccgcuca gagcgaaauu uaucgcugag aauuaccugc aggaccaucg ggaagucacg      120

aacguucgca auaugcuugg auauaccggc uucuacagcg ggcaacugau uuccgugaug      180

ggacacggca uggggauccc cucuaugaca cucuaugccc augagcuggu gaacgauuuu      240

gacgucaaga gaauuauccg ggugggaagc cuuggcgcca cccagcgcac aaucaaaaug      300

agagauauua uccuggcugu ugccuccggc accgacucug ugacaaauuu caagcggagc      360

uccggguacu uuauggcuuc uagcgccuau uucccucucc ugcagaaagc guggucccug      420

gcccaggaag cuggacucga ggucaaggcc ggcaacgugu uuagcgggga uauuuacuau      480

gaccccgaug acaaucugau cccugcucuu gaaaaguucg gaguucuggg cauugauaug      540

gagguggccg ggcucuacgc gcuggcccac caauuuggaa ucgaggcucu ugccauucug      600

accgucucug accauugccu cacgggcgaa gagaccacag cugaggaacg ccagcugacc      660

uucaacaaua ugaucgagcu ggcccucaac acagccgugg cuaucuga                   708


<210>  6216
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACD54493

<400>  6216
augacagcac acauaaaugc aaaacuagga gauuucgcac caacaguaau aaugccagga       60

gacccauuaa gagcaaaauu cauagcagaa aacuacuuac aagaucacag ggaaguaaca      120

aacgucagaa acaugcuagg auacacagga uucuacucag gacaauuaau aaguguaaug      180

ggacacggga ugggaauacc aucaaugaca uuauacgcac acgaauuagu aaacgacuuc      240

gacguuaaaa gaauaauaag aguaggaagc cuaggagcaa cccaaagaac aauaaaaaug      300

agagacauaa uacuagcagu agcaucagga acagacucag uaacaaacuu uaaaagaagu      360

ucaggauauu ucauggcauc aucagcauac uucccacuac uacaaaaagc auggucauua      420

gcacaagaag caggcuuaga aguaaaagca ggaaacguau ucucaggaga cauauacuau      480

gacccagacg acaacuuaau accagcacua gaaaaauucg gaguacuagg aauagacaug      540

gaaguagcug gacuauacgc auuagcacac caauucggaa uagaagcacu agcaaucuua      600

acaguaucag accacugccu aacaggagaa gaaacaacag cagaagaaag acaauuaaca      660

uucaacaaca ugauagaauu agcacuaaau acagcaguag caauauaa                   708


<210>  6217
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E0U7I4

<400>  6217

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6218
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6218
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cuacgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6219
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6219
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6220
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6220
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6221
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6221
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6222
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6222
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6223
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6223
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6224
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEE59766

<400>  6224
auggcaacac cacauauaaa cgcagaaaug ggggacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagaugc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca gggacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggcau accaucaugc aguauauaua caaaagaauu aauaacagac      240

uucggaguga aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauugg aaugggagca uguaccgaua gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagcc gauuucgaua ugguacgaaa ugcaguagac      420

gcagcaaagg cauuaggagu agacgcaaga guaggaaauc uauucagcgc agacuuauuu      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua cggaguagcc gcagaauuug gagcaaaagc acuuacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacuc gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6225
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E0VFI3

<400>  6225

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6226
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6226
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgaugug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6227
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6227
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6228
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6228
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6229
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6229
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6230
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6230
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6231
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6231
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6232
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AEQ15845

<400>  6232
auggcaacac cacauauaaa ugccgaaaug ggagacuuug cagacguagu acuaaugcca       60

ggagauccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaauggguau accaucaugu aguauauaca caaaagaauu aaucacagac      240

uuuggaguaa aaaaaauaau aagaguagga aguugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaca gcaaaguaaa uagaauaaga      360

uuuaaagacc augauuuugc cgcaauagca gauuucgaua ugguacgaaa cgcaguagac      420

gcagcaaaag cacuaggagu agaugcaaga guaggaaauu uauuuagcgc ggacuuauuu      480

uacagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacgaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acuuucaaug acaugauaaa aauagcauua gaaagcguuu uacuaggaga uaaagaauaa      720


<210>  6233
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E0Y455

<400>  6233

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6234
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6234
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6235
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6235
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6236
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6236
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6237
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6237
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6238
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6238
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6239
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6239
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6240
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFS76188

<400>  6240
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagaucccc uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaaguc      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacggac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguauuacc acacgugaaa      300

cuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cacuaggaau agacgcaaga gugggaaauu uauuuagcgc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaaucuu aggaguagaa      540

auggaagcgg caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacgaua      600

uguacaguaa gcgaucacau aagaacgcac gaacaaacaa cagcagcaga acgacaaaca      660

acauucaaug auaugauaaa aauagcacua gaaagcguac uauuaggcga uaaagaauaa      720


<210>  6241
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E1M7E2

<400>  6241

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6242
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6242
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggugu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6243
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6243
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6244
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6244
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6245
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6245
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6246
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6246
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6247
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6247
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6248
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJF59253

<400>  6248
auggcaacac cacauauaaa ugcagaaaug ggagauuuug cagauguagu acuaaugcca       60

ggagacccgc uaagagccaa auacauagca gaaacauuuu uagaagacgc aagagaaguc      120

aauaauguaa gagggauguu aggauuuaca ggaaccuaca aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accuucaugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

cuaagagaug uaguaauagg aaugggagcc uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuuugaca ugguaagaaa ugcaguggac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauuuagcgc agauuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau auggaauacu aggaguagaa      540

auggaagcag cagggauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gugaucauau aaggacgcac gaacaaacaa cagcagcaga aagacaaacu      660

acauuuaaug acaugauaaa aauagcacua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6249
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0E3KJD7

<400>  6249

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6250
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6250
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6251
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6251
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6252
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6252
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6253
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6253
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6254
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6254
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6255
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6255
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6256
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKA93549

<400>  6256
auggcaacac cacauauaaa cgcagaaaug ggagacuuug cagauguagu acuaaugccc       60

ggagauccac uaagagcaaa auacauagca gaaacauucu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu agguuuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguaggu ucgugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaagg guaggcaauu uauuuagugc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cuggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaauc      600

ugcacaguaa gugaucacau aagaacacau gaacaaacaa cagcagcaga acgacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguau uauuaggaga uaaagaauaa      720


<210>  6257
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0F6CCW6

<400>  6257

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6258
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6258
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcaaacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6259
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6259
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6260
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6260
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6261
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6261
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6262
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6262
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6263
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6263
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6264
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFJ32072

<400>  6264
auggcaacac cccauauaaa ugcagaaaug ggggacuuug cagauguagu acuaaugcca       60

ggggauccac uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagggaagua      120

aauaacguac gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggccaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uuguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcuauagca gauuucgaua ugguaagaaa ugccguagac      420

gcggcaaaag cacuaggaau agacgcgaga guaggaaauc uauuuagcgc agacuuauuc      480

uauagcccag acggagaaau guucgacgua auggaaaagu auggaauacu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauucg gagcaaaagc acuaacaaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauuuaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6265
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0F6FGI8

<400>  6265

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6266
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6266
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcaaacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6267
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6267
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6268
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6268
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6269
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6269
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6270
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6270
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6271
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6271
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6272
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJA29528

<400>  6272
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagauccac uaagagcuaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaacu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguggga aguugcggag caguucuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagacc acgauuucgc agcaauagca gauuuugaua ugguaagaaa ugcaguagau      420

gcagcgaaag cauuaggaau agacgcacga guaggaaauu uauuuagcgc agacuuauuc      480

uauagcccag acggggaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaggc auuaacaaua      600

ugcacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacagaca      660

acauucaaug acaugauaaa aauagcauua gaaaguguac uacuaggaga uaaagaauaa      720


<210>  6273
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0F6GWR2

<400>  6273

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6274
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6274
auggcuacuc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ucgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuucugua      180

augggccacg guauggguau cccguccugc uccaucuaca cuaaagaacu gaucaccgau      240

uucggcguga agaaaaucau ucgcguuggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgugacg uagugauugg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc agcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggugaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcag cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccauau ucgcacgcac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6275
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6275
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6276
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6276
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6277
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6277
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6278
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6278
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6279
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6279
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6280
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI57857

<400>  6280
auggcaacac cacauaucaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagccaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaaccuaua aaggacgaaa aauaagugua      180

augggacaug gaaugggaau accaaguugu ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa agaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

cuaagagaug uaguaauagg gaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagcgc agaccuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cggcagcaga aagacaaacg      660

acguucaaug acaugauaaa aauagcauua gaaagcguac uauuaggaga uaaagaguaa      720


<210>  6281
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0G2SIK5

<400>  6281

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6282
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6282
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggugacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgu guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6283
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6283
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6284
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6284
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6285
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6285
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6286
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6286
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6287
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6287
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6288
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJM76720

<400>  6288
auggcaacac cccauauaaa ugcagagaug ggagacuucg cagauguagu acuaaugcca       60

ggagauccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc gagagaagua      120

aacaacguaa gaggaaugcu aggauuuaca ggaacauaua aaggaagaaa aauaucaguc      180

augggacaug gcaugggaau accaaguugu aguauauaua ccaaagaauu aauaacagac      240

uuuggaguca aaaaaauaau aagaguagga ucaugcggag caguacuccc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua guaagguaaa uagaauacga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcacga guaggaaauc uauuuagcgc agacuuauuc      480

uauagcccgg acggagaaau guuugaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagggauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6289
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0G3J9R6

<400>  6289

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6290
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6290
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagccg cuggcaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6291
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6291
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6292
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6292
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6293
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6293
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6294
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6294
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6295
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6295
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6296
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK37374

<400>  6296
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagggaagua      120

aauaacguca gaggaauguu aggcuuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaucaugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga aguuguggag caguacuacc acacguaaaa      300

cuaagagacg uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaggauc augauuucgc agcuauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cccuaggagu agacgcaaga gugggaaauc uauuuagugc agaccuauuc      480

uauagcccgg acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguau cagaucacau aagaacacac gaacaaacaa cagcagccga aagacaaacu      660

acguuuaaug acaugauaaa aauagcacua gaaagugugc uauuaggaga uaaagaauaa      720


<210>  6297
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0G3J9Y2

<400>  6297

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6298
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6298
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggugacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgu guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6299
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6299
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6300
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6300
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6301
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6301
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6302
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6302
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6303
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6303
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6304
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK35966

<400>  6304
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuu uagaagaugc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguggga ucaugcggag caguacuacc acacguuaaa      300

cuaagagaug uaguaauagg aaugggagca uguaccgaua gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaua ugguaaggaa ugcaguagac      420

gcggcaaaag cauuaggagu ggacgcaaga guaggaaauu uauuuagcgc agacuuauuc      480

uauagcccag auggagaaau guucgaugua auggaaaaau augggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcggcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6305
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0G3KD68

<400>  6305

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6306
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6306
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6307
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6307
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6308
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6308
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6309
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6309
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6310
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6310
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6311
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6311
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6312
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKK51383

<400>  6312
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguugu auuaaugcca       60

ggagacccau uaagagccaa guacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguga gaggaauguu aggauuuaca ggaacauaua aaggaaggaa aauaagcgua      180

augggccaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uucggaguaa aaaaaauaau aagaguagga ucauguggag cagugcuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagcc uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaua ugguacgaaa ugcaguagac      420

gcagcaaaag cauuaggagu agaugcaaga guaggaaauc uauuuagcgc ggacuuauuc      480

uauagcccag acggagaaau guucgacgua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguaccguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga acgacaaacc      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uacuaggaga uaaagaauaa      720


<210>  6313
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0H2Z6H1

<400>  6313

Met Asp Leu Gly Gly Ala Val Thr Pro Pro Leu Ile Cys His Lys Lys 
1               5                   10                  15      


Asp Lys Met Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe 
            20                  25                  30          


Ala Asp Val Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile 
        35                  40                  45              


Ala Glu Thr Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly 
    50                  55                  60                  


Met Leu Gly Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met 
65                  70                  75                  80  


Gly His Gly Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu 
                85                  90                  95      


Ile Thr Asp Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly 
            100                 105                 110         


Ala Val Leu Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly 
        115                 120                 125             


Ala Cys Thr Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp 
    130                 135                 140                 


Phe Ala Ala Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala 
145                 150                 155                 160 


Ala Lys Ala Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala 
                165                 170                 175     


Asp Leu Phe Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys 
            180                 185                 190         


Tyr Gly Ile Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val 
        195                 200                 205             


Ala Ala Glu Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp 
    210                 215                 220                 


His Ile Arg Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr 
225                 230                 235                 240 


Phe Asn Asp Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp 
                245                 250                 255     


Lys Glu 
        


<210>  6314
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6314
auggauuugg gcggagcagu gacuccgccu uuaauauguc acaaaaagga uaaaaugaug       60

gcuacuccac acauuaaugc agaaaugggc gauuuugcug acguaguuuu gaugccaggu      120

gacccgcugc gugcgaagua uauugcugaa acuuuccuug aagaugcccg ugaagugaac      180

aacguucgcg guaugcuggg cuucacuggu acuuacaaag gccgcaaaau uuccguaaug      240

ggccacggua uggguauccc guccugcucc aucuacacca aagaacugau cacugauuuc      300

ggcgugaaga aaauuauccg cguugguucc uguggcgcug uucugccgca cguaaaacug      360

cgcgacgucg uuaucgguau gggugccugc accgauucca aaguuaaccg cauccguuuu      420

aaagaccaug acuuugccgc uaucgcugac uucgacaugg ugcguaacgc gguagacgcg      480

gcaaaagcac ugggcguuga ugcucguguu gguaaccugu ucuccgcuga ccuguucuac      540

ucuccggacg gcgaaauguu cgacgugaug gaaaaauacg gcauccucgg cguggaaaug      600

gaagcggcug guaucuacgg cgucgcugca gaauuuggcg cgaaagcccu gaccaucugc      660

accgugucug accacauccg cacucacgag cagaccacug ccgcugagcg ucagaccacc      720

uucaacgaca ugaucaaaau cgcgcuggaa uccguucugc ugggcgauaa agaguaa         777


<210>  6315
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6315
auggaccugg gcggggccgu gacgcccccg cucaucugcc acaagaagga caagaugaug       60

gccacgcccc acaucaacgc ggagaugggc gacuucgccg acgucgugcu gaugcccggg      120

gacccccugc gcgccaagua caucgccgag accuuccucg aggacgcccg ggaggugaac      180

aacguccgcg gcaugcuggg guucaccggc accuacaagg gccggaagau cagcgugaug      240

gggcacggca uggggauccc guccugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucauccg cgucgggucc ugcggcgcgg ugcuccccca cgugaagcug      360

cgggacgucg ugaucggcau gggggccugc accgacagca aggugaaccg cauccgguuc      420

aaggaccacg acuucgccgc caucgcggac uucgacaugg uccgcaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgcgcggguc gggaaccucu ucuccgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg gguggagaug      600

gaggccgccg gcaucuacgg ggucgccgcg gaguucggcg ccaaggcccu caccaucugc      660

accguguccg accacauccg cacgcacgag cagaccaccg ccgccgagcg gcagaccacg      720

uucaacgaca ugaucaagau cgcgcuggag agcgugcugc ucggggacaa ggaguga         777


<210>  6316
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6316
auggaccucg gcggcgccgu cacccccccc cucaucugcc acaagaagga caagaugaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acgucguccu caugcccggc      120

gacccccucc gcgccaagua caucgccgag accuuccucg aggacgcccg cgaggucaac      180

aacguccgcg gcaugcucgg cuucaccggc accuacaagg gccgcaagau cuccgucaug      240

ggccacggca ugggcauccc cuccugcucc aucuacacca aggagcucau caccgacuuc      300

ggcgucaaga agaucauccg cgucggcucc ugcggcgccg uccuccccca cgucaagcuc      360

cgcgacgucg ucaucggcau gggcgccugc accgacucca aggucaaccg cauccgcuuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg uccgcaacgc cgucgacgcc      480

gccaaggccc ucggcgucga cgcccgcguc ggcaaccucu ucuccgccga ccucuucuac      540

ucccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccucgg cgucgagaug      600

gaggccgccg gcaucuacgg cgucgccgcc gaguucggcg ccaaggcccu caccaucugc      660

accgucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg ccagaccacc      720

uucaacgaca ugaucaagau cgcccucgag uccguccucc ucggcgacaa ggaguga         777


<210>  6317
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6317
auggaccugg gcggggccgu gacucccccu cucaucugcc acaagaaaga uaagaugaug       60

gcuacaccac auauuaacgc agagauggga gacuucgccg augucguucu uaugccgggu      120

gacccccuga gagcgaaaua cauagcugaa accuuuuugg aggaugccag ggaagugaau      180

aacguacggg gcauguuagg guucacggga accuauaagg gccgcaaaau cagcgugaug      240

ggucacggga ugggcauucc uuccuguucu aucuacacaa aggagcugau uacugacuuu      300

ggagucaaga aaaucauacg agugggcuca ugcggggcag uucuaccaca ugugaagcuc      360

cgugaugucg ugaucggaau gggugccugu accgacagua aaguaaauag aauuagguuc      420

aaggaucacg acuuugcugc aaucgccgau uucgacaugg uucggaacgc uguggaugcc      480

gcgaaagcac ugggcgucga cgcccgcgug gggaaucuuu uuagcgcuga ccuguucuau      540

ucccccgaug gagaaauguu ugacgugaug gagaaguacg gcauuuuggg ugucgagaug      600

gaagccgcag ggaucuaugg aguugcugcc gaguucggcg cgaaggcccu cacaauaugc      660

accgugucug aucauauuag aacucacgaa cagacaaccg cagcugagag gcaaacgacu      720

uuuaacgaca ugaucaaaau ugcccuggag ucgguacugc ucggcgauaa ggaauga         777


<210>  6318
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6318
auggaccugg gcggcgccgu gacccccccc cugaucugcc acaagaagga caagaugaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acguggugcu gaugcccggc      120

gacccccuga gagccaagua caucgccgag accuuccugg aggacgccag agaggugaac      180

aacgugagag gcaugcuggg cuucaccggc accuacaagg gcagaaagau cagcgugaug      240

ggccacggca ugggcauccc cagcugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucaucag agugggcagc ugcggcgccg ugcugcccca cgugaagcug      360

agagacgugg ugaucggcau gggcgccugc accgacagca aggugaacag aaucagauuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg ugagaaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgccagagug ggcaaccugu ucagcgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg cguggagaug      600

gaggccgccg gcaucuacgg cguggccgcc gaguucggcg ccaaggcccu gaccaucugc      660

accgugagcg accacaucag aacccacgag cagaccaccg ccgccgagag acagaccacc      720

uucaacgaca ugaucaagau cgcccuggag agcgugcugc ugggcgacaa ggaguga         777


<210>  6319
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6319
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaugaug       60

gcuaccccgc auauuaacgc cgagauggga gacuucgcgg augucguucu gaugcccggc      120

gacccucuua gagcuaaaua caucgccgaa acguuucugg aggaugcccg ggaagugaau      180

aacgugcgcg ggaugcucgg auucaccggc acauauaagg ggagaaaaau uagcgucaug      240

ggacacggca ugggcauccc cuccuguucu auuuacacca aggagcugau cacagacuuu      300

ggggugaaga aaaucauucg gguuggaagc ugcggcgcug ugcuuccuca ugucaagcug      360

cgcgaugugg uuaucgggau gggagccugu accgacucca aagugaaucg gauuagauuc      420

aaggaucacg acuuugcugc caucgcggau uucgacaugg uccgcaacgc cguggaugcu      480

gccaaagcuc ucggcgugga cgccagaguc gggaaucugu uuucugcgga ccuguucuau      540

agccccgaug gagaaauguu ugacguuaug gagaaguacg gcauucucgg cguggagaug      600

gaagccgcug ggaucuaugg aguggccgcu gaguucggcg ccaaggcccu gacaauuugc      660

accgucuccg aucauauccg gacgcacgaa cagaccacag cugcggagcg ccaaaccaca      720

uuuaacgaca ugaucaaaau ugcccuugag ucugugcugc ucggggauaa ggaauga         777


<210>  6320
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABJ03941

<400>  6320
auggauuuag gaggagcagu aacgccacca cuaauaugcc auaaaaaaga caaaaugaug       60

gcaacaccac auauaaaugc agaaauggga gacuuugcag auguaguauu aaugccagga      120

gacccacuaa gagcaaaaua cauagcagaa acauuucuag aagacgcaag agaaguaaau      180

aauguacgag gaauguuagg auuuacagga acauauaaag gaagaaaaau aucaguaaug      240

ggacauggaa ugggaauacc aucaugcagc auauauacaa aagaauuaau aacagauuuu      300

ggaguaaaaa aaauaauacg aguaggaagu ugcggagcag uacuaccaca cguaaaauua      360

agagauguag uaauaggaau gggagccugu acagauagca aaguaaauag aauuagauuu      420

aaagaucacg acuucgcagc aaucgcagau uucgauaugg uaagaaaugc aguggacgcg      480

gcaaaagcau uaggaguaga cgcaagagua ggaaauuuau uuagugcuga cuuauuuuau      540

agcccagacg gagaaauguu cgauguaaug gaaaaauacg gaauacuagg aguagaaaug      600

gaagcagcag gaauauaugg aguagcagca gaauuuggag caaaagcacu aacaauaugc      660

acaguaucag aucauauaag aacacaugaa caaacgacag cagcagaaag acaaacaaca      720

uucaaugaua ugauaaaaau agcauuagaa aguguacuau uaggagauaa ggaauaa         777


<210>  6321
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0H3EQW1

<400>  6321

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6322
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6322
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggu uccuguggug cuguucugcc gcacguaaaa      300

cugcgugacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6323
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6323
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6324
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6324
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6325
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6325
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6326
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6326
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6327
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6327
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6328
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADR29841

<400>  6328
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugccc       60

ggagacccgc uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aagggagaaa aauaucagua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

cuaagagaug uaguaauagg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuuugaua ugguaagaaa ugcaguggac      420

gcagcaaaag cauugggagu agaugcaaga guaggaaauc uauuuagcgc agacuuguuc      480

uauagcccag acggagaaau guuugaugua auggaaaaau acggaauacu aggaguagaa      540

auggaagcag caggaauaua uggcguagca gcagaauuug gagcaaaagc acuaacgaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6329
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0H3XF09

<400>  6329

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6330
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6330
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6331
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6331
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6332
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6332
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6333
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6333
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6334
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6334
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6335
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6335
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6336
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AKM37993

<400>  6336
auggcaacgc cucauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccuu uaagagcaaa guacauagca gagacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauucaca ggaacauaua aaggacgaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaca caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguaggu ucaugcggag caguauuacc acacguaaaa      300

uuacgagaug uaguaaucgg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agccauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcuaaag cauuaggaau agacgcaaga guaggaaauc uauuuagugc agaccuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gugaucacau acguacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6337
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli_
       _A0A0J9WZC9

<400>  6337

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6338
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6338
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacuggguau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6339
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6339
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6340
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6340
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6341
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6341
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6342
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6342
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6343
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6343
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6344
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAL40848

<400>  6344
auggcaacac cacauauaaa cgcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcgaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accuucaugc aguauauaua caaaagaacu aauaacggau      240

uuuggaguaa aaaaaauaau aagaguagga ucauguggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggggcc uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguggac      420

gcagcaaaag cacuaggaau agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauaguccgg acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag ccggaauaua uggaguagca gcagaauuug gagcgaaagc auuaacaaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac ucuuaggaga uaaagaauaa      720


<210>  6345
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__A7ZVS7

<400>  6345

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6346
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6346
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6347
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6347
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6348
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6348
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6349
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6349
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6350
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6350
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6351
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6351
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6352
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV17365

<400>  6352
auggcaacac cacauauaaa ugcagaaaug ggagacuucg cagacguugu acuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggcuuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaucaugc aguauauaua caaaagaacu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagggaug uagugauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uucaaagauc acgauuucgc agcaauagca gauuucgaca ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagcgc agaccuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauacu aggaguggaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguga gcgaucacau aagaacacac gaacaaacaa cagcggcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguau uauuaggaga uaaagaauaa      720


<210>  6353
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__A8A8B3

<400>  6353

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6354
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6354
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6355
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6355
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6356
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6356
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6357
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6357
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6358
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6358
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6359
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6359
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6360
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABV08767

<400>  6360
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagacguagu acuaaugcca       60

ggagacccac uuagagcaaa auacauagca gaaacauuuc uagaagacgc uagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugu agcauauaua caaaagaacu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucuugcgggg caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagauu caaaaguaaa uagaauacga      360

uuuaaagauc acgauuucgc agcaauagca gacuuugaua ugguaagaaa ugcaguagac      420

gcggcaaaag cuuuaggaau agacgcaaga guaggaaauu uauuuagugc agacuuauuc      480

uauagcccag auggagaaau guucgaugua auggaaaaau auggaauauu aggcguggaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaccauau acgaacacac gaacaaacaa cagcagccga aagacaaaca      660

acauuuaaug auaugauaaa aauagcauua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6361
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B1IS35

<400>  6361

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6362
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6362
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguaa agaaaauuau ccgcguaggc uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6363
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6363
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6364
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6364
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6365
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6365
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6366
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6366
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6367
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6367
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6368
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACA79283

<400>  6368
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauugca gaaaccuuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaaguugu ucgauauaua caaaagaauu aauaacagac      240

uuuggcguaa aaaaaauaau aagaguagga agcugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagcc uguacagaua gcaaaguaaa uagaauuaga      360

uuuaaagauc acgauuuugc ggcaauagcc gauuuugaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu ggacgcaaga guaggaaauc uauuuagugc agacuuauuu      480

uauagcccag acggggaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguggca gcggaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagccga aagacaaaca      660

acguucaaug acaugauaaa aauagcacua gaaaguguau uauuaggaga uaaagaauaa      720


<210>  6369
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B1LEI9

<400>  6369

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6370
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6370
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

auggggcacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuu      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6371
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6371
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6372
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6372
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6373
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6373
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6374
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6374
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6375
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6375
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6376
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB16204

<400>  6376
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gcaugggaau accaucaugu ucaauuuaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaaucau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug ucguaauugg aaugggagca ugcacagaua guaaaguaaa uagaauaaga      360

uucaaagauc augauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cacuaggaau agacgcaaga guagguaauc uauuuagcgc agacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggcguagca gcagaauuug gcgcaaaagc acuaacgaua      600

uguaccguaa gcgaucauau aagaacgcac gaacagacaa cagcggcaga gagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6377
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B1XFJ4

<400>  6377

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6378
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6378
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacuggguau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6379
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6379
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6380
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6380
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6381
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6381
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6382
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6382
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6383
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6383
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6384
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACB05312

<400>  6384
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacguaua aaggaagaaa aaucucagua      180

augggacaug gaaugggaau accaucaugu aguauauaua ccaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauuaga      360

uuuaaagauc acgacuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagau      420

gcggcaaaag cauuaggaau agacgcaaga guaggaaauu uauuuagugc ggacuuauuu      480

uauagcccag auggagaaau guucgaugua auggaaaaau acggaauacu aggaguagaa      540

auggaagcag caggaauaua cggaguagca gcggaauuug gagcaaaagc auuaacaauc      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acguucaaug acaugauaaa aauagcacua gaaaguguac uauuaggcga uaaagaauaa      720


<210>  6385
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B3HEI4

<400>  6385

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6386
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6386
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cuacgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6387
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6387
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6388
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6388
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6389
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6389
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6390
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6390
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6391
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6391
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6392
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AIF62240

<400>  6392
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aagggagaaa aauaagugua      180

augggccaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uucggaguaa aaaagauaau aagaguagga ucaugcggag caguacuacc acacgugaaa      300

uuaagagaug uaguaauagg aaugggugca uguacagaca gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagcc gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauagcccag acggagaaau guuugaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaauc      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6393
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B5Z4R6

<400>  6393

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6394
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6394
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcaaacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6395
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6395
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6396
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6396
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6397
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6397
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6398
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6398
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6399
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6399
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6400
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI39330

<400>  6400
auggcaacac cacauauaaa ugcugaaaug ggagacuucg cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auauauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gagggauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaagcugc ucaaucuaua caaaggaacu aauaacagac      240

uuuggaguga aaaaaauaau aagaguagga aguugcggag caguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuuugaua ugguaagaaa ugccguagac      420

gcagcaaaag cauuggggau agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauagcccag acggggaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaucacau aagaacacau gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguau uauuaggcga uaaagaauaa      720


<210>  6401
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B6I6N1

<400>  6401

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6402
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6402
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6403
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6403
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6404
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6404
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6405
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6405
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6406
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6406
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6407
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6407
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6408
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAG80183

<400>  6408
auggcaacac cacauaucaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucaguu      180

augggacaug gaaugggaau accaucaugc agcauauaua caaaagaacu gauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagacc acgauuucgc agcaauagca gauuuugaua ugguaagaaa ugcaguugac      420

gcagcaaaag cauuaggaau agacgcaaga guuggaaauc uauuuagcgc agacuuauuc      480

uauagcccag acggggaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagggauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gugaucacau aagaacgcac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguac uauuaggcga uaaagaauaa      720


<210>  6409
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7LEN0

<400>  6409

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6410
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6410
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6411
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6411
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6412
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6412
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6413
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6413
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6414
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6414
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6415
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6415
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6416
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV02186

<400>  6416
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacuuuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuaca ggaacauaua aaggacgaaa aauaaguguc      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug ucguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagcc gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cacuaggaau agacgcgaga guaggaaauc uauuuagcgc agacuuauuu      480

uauagcccgg acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagggauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguau cagaucacau aagaacacac gaacaaacaa cagcagcaga gagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguac uacuaggcga uaaagaauaa      720


<210>  6417
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7LXU6

<400>  6417

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6418
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6418
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6419
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6419
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6420
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6420
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6421
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6421
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6422
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6422
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6423
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6423
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6424
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR01347

<400>  6424
auggcaacac cacauauaaa ugcagaaaug ggagauuuug cagauguagu auuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuacc ggaacauaua aagggagaaa aauaucagua      180

augggacaug gaaugggaau accaagcugc aguauauaua caaaagaauu aauaacagau      240

uuuggaguaa aaaaaauaau aagaguagga aguuguggag caguauuacc acauguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc ugcaauagca gauuucgaua ugguacggaa ugcaguggac      420

gcagcaaaag cauuaggaau agacgcgaga guaggaaauc uauuuagugc agaccuauuc      480

uauagcccag acggagaaau guucgacgua auggaaaaau auggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcggaauuug gagcaaaagc auuaacgaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6425
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7MNJ1

<400>  6425

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6426
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6426
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacuggguau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6427
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6427
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6428
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6428
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6429
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6429
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6430
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6430
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6431
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6431
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6432
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR06204

<400>  6432
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu gcuaaugccc       60

ggagacccac uaagggcaaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaaguugc ucaauauaua ccaaagaauu aauaacagau      240

uuuggaguua aaaaaauaau aagaguagga aguugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc ggcaauagca gauuuugaua ugguacgaaa ugccguagac      420

gcagccaaag cacuaggaau ugacgcaaga guuggaaauu uauuuagugc agacuuauuu      480

uauaguccag acggagaaau guucgaugug auggaaaaau acggaauauu aggaguggaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacua cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcgugc uauuaggaga caaagaauaa      720


<210>  6433
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7N2V8

<400>  6433

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6434
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6434
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggugacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgu guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6435
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6435
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6436
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6436
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6437
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6437
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6438
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6438
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6439
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6439
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6440
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAV18213

<400>  6440
auggccacac cacauaucaa ugcagaaaug ggagacuucg cagauguagu guuaaugcca       60

ggagauccac uacgagcaaa auacauagca gaaacauuuc uagaagaugc aagagaagua      120

aauaacguaa gaggaauguu aggcuuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauuuucagc agacuuauuu      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauccu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacau gagcaaacaa cagcagcaga aagacaaaca      660

acauuuaaug acaugauaaa aauagcccua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6441
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7NH52

<400>  6441

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6442
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6442
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccguacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6443
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6443
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6444
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6444
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6445
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6445
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6446
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6446
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6447
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6447
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6448
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR16117

<400>  6448
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauucc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggguuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaaguugu ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguggga aguugcggag caguacuacc gcacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagauu caaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguggac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagugc agacuuauuc      480

uauucaccag acggagaaau guucgaugua auggaaaaau auggaauauu aggaguagaa      540

auggaagcag caggaauaua cggaguagca gcagaauuug gagcaaaagc acuaacuaua      600

uguacuguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaacg acaugauaaa aauagcacua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6449
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7NW64

<400>  6449

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6450
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6450
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgaugug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6451
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6451
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6452
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6452
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6453
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6453
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6454
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6454
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6455
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6455
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6456
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAR21012

<400>  6456
auggcaacac cacauauaaa ugcagaaaug ggugacuuug cagaugucgu acuaaugcca       60

ggagacccau uaagagccaa auacauugca gaaacauucu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu gggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggcau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguauuacc acacguaaaa      300

uuaagagaug uaguaaucgg aaugggagcc uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc ggcaauagca gauuucgaua ugguacgaaa ugcaguagac      420

gcagcaaaag cauugggagu agacgcaaga guaggaaacc uauuuucagc agauuuauuu      480

uauagcccag auggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagguauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aaggacacac gaacaaacaa cagcagcaga aaggcaaacu      660

acauuuaaug acaugauaaa aauagcacua gaaagcguau uauugggcga uaaagaauaa      720


<210>  6457
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__B7UR12

<400>  6457

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6458
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6458
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggggcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc uacugggcga uaaagaguaa      720


<210>  6459
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6459
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6460
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6460
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6461
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6461
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6462
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6462
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6463
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6463
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6464
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CAS12230

<400>  6464
auggcaacac cacauauaaa cgcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac ucagagcaaa auacauagca gagaccuuuc uggaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucaguc      180

augggacaug gaaugggaau accaucaugc ucaauauaua ccaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucgugcggag caguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa ucgaauaaga      360

uuuaaagauc acgauuuugc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauucagcgc ugacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguggaa      540

auggaagcug caggaauaua uggaguagca gcagaauuug gcgcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau acgaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6465
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__C3SE47

<400>  6465

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6466
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6466
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcaaacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6467
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6467
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6468
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6468
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6469
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6469
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6470
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6470
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6471
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6471
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6472
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACI72751

<400>  6472
auggcaacac cacauauaaa ugcagaaaug ggagacuucg cggacguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguga gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaauggguau accaucaugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga aguugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggggca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguacgaaa ugcaguagac      420

gcagcaaagg cauuaggaau agacgcaaga guaggaaacc uauuuagcgc agacuuauuc      480

uacaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcuaaagc acuaacaaua      600

ugcacaguga gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6473
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__C4ZT66

<400>  6473

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6474
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6474
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacuggguau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6475
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6475
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6476
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6476
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6477
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6477
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6478
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6478
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6479
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6479
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6480
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ACR65334

<400>  6480
auggcaacac cacauauaaa ugcggaaaug ggagauuuug cagacguagu auuaaugcca       60

ggugacccac uaagagcaaa auacauagca gaaacauuuu uagaagaugc aagagaagua      120

aauaacguaa ggggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accauccugc ucaauauaua caaaagaauu aauaacagac      240

uucggaguaa aaaaaauaau aagaguaggc aguuguggag cuguauuacc acacguaaaa      300

cuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguugac      420

gcagccaaag ccuuaggaau agaugcaaga guaggaaacu uauucagcgc agaucuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag ccggaauaua uggaguagca gcagaauuug gagcaaaagc acugacaaua      600

uguacaguau cagaucacau acgaacacau gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6481
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__C8TQD7

<400>  6481

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6482
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6482
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6483
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6483
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6484
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6484
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6485
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6485
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6486
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6486
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6487
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6487
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6488
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI28709

<400>  6488
auggcaacgc cacauauaaa ugcagaaaug ggagacuuug cagauguagu uuuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca gggacauaua aagguagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacugac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauugggagu agacgcaaga guaggaaauc uauuuagugc agacuuauuc      480

uauagcccgg acggagaaau guucgaugua auggaaaaau acggaauauu aggcguagaa      540

auggaagcag caggaauaua uggaguagcc gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gagcaaacaa cagcggcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6489
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__C8U157

<400>  6489

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6490
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6490
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6491
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6491
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6492
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6492
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6493
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6493
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6494
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6494
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6495
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6495
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6496
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI33919

<400>  6496
auggcaacac cacauauaaa ugccgaaaug ggagacuuug cagauguagu auuaaugcca       60

ggggacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaca aaggaagaaa aauaucagua      180

augggacaug gaaugggaau acccucaugc aguauauaua caaaagaauu aaucacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua guaaaguaaa cagaauacga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggcau agacgcaaga guaggaaauc uuuuuagcgc agacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc auuaacaaua      600

uguacaguaa gcgaucauau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aaucgcacua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6497
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__C8UN92

<400>  6497

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6498
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6498
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca ugguacguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6499
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6499
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6500
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6500
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6501
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6501
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6502
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6502
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6503
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6503
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6504
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__BAI38958

<400>  6504
auggcaacac cacauauaaa ugcagaaaug ggugacuuug cagauguagu auuaaugcca       60

ggagauccgc uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuaca ggaaccuaua aaggaagaaa aaucucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucauguggag caguauuacc acauguaaaa      300

uuaagagaug uagugauagg aaugggagca uguacagauu caaaagucaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagcc gauuucgaua uggugcgaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagugc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauacu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcuga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagugugc uacuaggaga uaaagaauaa      720


<210>  6505
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__D3GY24

<400>  6505

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6506
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6506
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggugu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6507
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6507
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6508
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6508
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6509
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6509
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6510
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6510
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6511
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6511
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6512
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBG37702

<400>  6512
auggcaacac cacauaucaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguauuacc acacguaaaa      300

uugagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaca ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agaugcaaga guaggaaauc uauuuagcgc ggacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau auggaauacu gggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcgaaagc acuaacaaua      600

uguaccguaa gugaucauau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6513
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__D3QNE6

<400>  6513

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6514
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6514
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcaaacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6515
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6515
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6516
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6516
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6517
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6517
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6518
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6518
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6519
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6519
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6520
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADD59655

<400>  6520
auggcaacac cucauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua ccaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcgggg caguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugccguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagcgc agauuuauuc      480

uauaguccag auggagaaau guucgaugua auggaaaaau acggaauauu aggaguagag      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguga gugaucacau aagaacacau gaacaaacaa cagcggcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcgcua gaaaguguau uauuaggaga uaaagaauaa      720


<210>  6521
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__D6I4N2

<400>  6521

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6522
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6522
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6523
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6523
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6524
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6524
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6525
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6525
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6526
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6526
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6527
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6527
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6528
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFE60543

<400>  6528
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auauauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu agguuuuaca ggaacauaua aaggaagaaa aauaagugua      180

auggggcaug gaaugggaau accaucaugc aguauauaua cuaaagaacu aauaacagac      240

uuuggaguga aaaaaauaau aagaguagga aguugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cacuaggaau agaugcaaga guaggaaauc uauuuagcgc agaccuauuc      480

uauaguccug acggugaaau guucgaugua auggaaaaau acggaauauu agggguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gggcaaaagc auuaacaaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa ccgcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac uacuaggaga uaaagaguaa      720


<210>  6529
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__D6IHU2

<400>  6529

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6530
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6530
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaucacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6531
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6531
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6532
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6532
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6533
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6533
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6534
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6534
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6535
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6535
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6536
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF03573

<400>  6536
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagauccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggcuucaca ggaacauaua aaggaaggaa aauaagcgua      180

augggacaug gcaugggaau accaucaugu ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguaggc ucaugcggag caguacuacc ucauguaaaa      300

uuaagggaug uaguaauagg aaugggagcc uguacagaua gcaaaguaaa ucgaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauu uauuuagcgc agauuuauuu      480

uauaguccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucauau aagaacacau gaacaaacaa cagcagccga aagacaaaca      660

acauucaaug acaugauaaa aaucgcacua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6537
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__D6J6A4

<400>  6537

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6538
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6538
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc ucuuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg uaguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagau      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcguggcu gcagaguuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6539
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6539
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6540
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6540
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6541
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6541
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6542
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6542
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6543
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6543
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6544
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EFF14801

<400>  6544
auggcgacac cacauauaaa cgcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggggacccau uaagagcaaa auacauagcc gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau acccucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaagauaau aagaguagga ucaugcggag ccguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagau      420

gcagcaaaag cacuaggagu agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauaguccag auggagaaau guuugaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag cagggauaua uggaguggca gcagaauucg gagcaaaagc acuaacaaua      600

uguacagugu cagaucauau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6545
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__E0J437

<400>  6545

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6546
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6546
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6547
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6547
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6548
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6548
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6549
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6549
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6550
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6550
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6551
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6551
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6552
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFH14259

<400>  6552
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagacguagu auuaaugcca       60

ggagacccau uaagagcaaa auacauagca gaaacauuuc uagaagaugc aagagaagua      120

aauaacguaa gaggaauguu aggcuuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaagcugc ucaauauaua caaaagaacu gauaacagac      240

uuuggaguaa aaaaaauaau aagaguggga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguaccgaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuuugaua ugguaagaaa ugcaguggac      420

gcagcaaaag cauuaggaau agaugcaaga gugggaaauc ucuuuagugc ggaccuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagcc gcagaauuug gcgcaaaagc auuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug auaugauaaa aauagcacua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6553
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__E2QLE4

<400>  6553

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6554
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6554
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cggguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6555
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6555
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6556
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6556
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6557
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6557
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6558
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6558
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6559
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6559
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6560
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AJO86506

<400>  6560
auggcaacac cacauauaaa ugcagaaaug ggagacuucg cagauguagu acuaaugcca       60

ggagacccac uaagagcaaa auauauagca gaaacauuuc uagaagacgc aagagaagua      120

aacaacguaa gagguauguu aggauuuaca ggaacauaua aaggaagaaa aauaagugua      180

augggacaug gaaugggaau accaucaugu aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag ccguacuacc acacguaaaa      300

cuaagagaug uaguaauagg aaugggagcc uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaca ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggagu agacgcgaga guaggaaauu uauuuagcgc agacuuauuc      480

uauucaccag acggagaaau guucgaugua auggaaaaau auggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6561
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__E3PFG7

<400>  6561

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6562
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6562
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cuacgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6563
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6563
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6564
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6564
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6565
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6565
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6566
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6566
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6567
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6567
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6568
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CBJ04246

<400>  6568
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagauccau uaagagcaaa auauauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuaca ggaacauaua aagguagaaa aauaucagua      180

augggacaug gaaugggaau acccucaugc agcauauaua caaaagaauu aauaacagac      240

uucggaguga aaaaaauaau aagaguagga ucauguggag caguacuacc acacgugaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agccauagca gauuucgaua ugguaagaaa cgcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauc uauuuagcgc agacuuguuc      480

uauucaccag acggggaaau guucgaugua auggaaaaau acggaauuuu aggcguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau uagaacacau gaacaaacaa cagcagcuga acgacaaaca      660

acauucaaug acaugauaaa aauagcacua gagaguguac uauuaggaga uaaagaauaa      720


<210>  6569
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__E8YEH0

<400>  6569

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6570
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6570
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6571
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6571
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6572
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6572
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6573
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6573
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6574
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6574
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6575
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6575
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6576
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ADX52500

<400>  6576
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu gcuaaugcca       60

ggggacccac uaagagcgaa auacauagca gaaacauuuc uagaagacgc gagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucgugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguacuacc acacguaaaa      300

cuaagagaug uaguaauagg gaugggagca uguacagaua gcaaaguaaa uagaauacga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguacgaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauu uauuuagcgc agauuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcggcaga aagacaaaca      660

acguuuaaug acaugauaaa aauagcacuc gaaagcgugc uauuaggaga uaaagaauaa      720


<210>  6577
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4NLK2

<400>  6577

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6578
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6578
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6579
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6579
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6580
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6580
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6581
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6581
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6582
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6582
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6583
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6583
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6584
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGJ07033

<400>  6584
auggcaacac cacauauaaa ugcagaaaug ggagauuuug cagauguagu acuaaugcca       60

ggagauccac uaagggccaa auauauugca gaaacauuuc uagaagaugc aagagaagua      120

aauaacguac gaggaaugcu aggauuuacc ggaacauaua aaggaagaaa aaucucagua      180

augggacaug gaaugggcau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau acgaguagga ucguguggag caguacuccc ucacguaaaa      300

uuaagagaug uaguuauagg aaugggagcc uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaaggaa ugcaguggac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaacu uauuuagugc agacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcggaauuug gagcaaaagc acuaacaaua      600

uguaccguga gugaucacau aagaacacac gaacaaacaa cugcagcaga aagacaaaca      660

acauuuaaug auaugauaaa aauagcacua gaaaguguac uauuaggaga uaaagaauaa      720


<210>  6585
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4SEX7

<400>  6585

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6586
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6586
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6587
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6587
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6588
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6588
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6589
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6589
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6590
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6590
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6591
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6591
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6592
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI12380

<400>  6592
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auauauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu gggauucaca ggaacauaua aaggaagaaa aauaucagua      180

augggacacg gcaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau acgaguagga ucaugcggag ccguacuacc acacguaaaa      300

uuaagagacg uaguaauagg aaugggagca uguacagaua guaaaguaaa cagaauacga      360

uuuaaagauc augauuucgc agcaauagca gauuuugaua ugguaagaaa ugcaguagac      420

gcugcaaaag cacuaggagu agacgcaaga guaggaaauc uauuuagugc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acgggauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacgaua      600

uguacaguga gcgaucacau aagaacacac gaacaaacga cagcagccga acgacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6593
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4STB8

<400>  6593

Met Asp Leu Gly Gly Ala Val Thr Pro Pro Leu Ile Cys His Lys Lys 
1               5                   10                  15      


Asp Lys Thr Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe 
            20                  25                  30          


Ala Asp Val Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile 
        35                  40                  45              


Ala Glu Thr Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly 
    50                  55                  60                  


Met Leu Gly Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met 
65                  70                  75                  80  


Gly His Gly Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu 
                85                  90                  95      


Ile Thr Asp Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly 
            100                 105                 110         


Ala Val Leu Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly 
        115                 120                 125             


Ala Cys Thr Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp 
    130                 135                 140                 


Phe Ala Ala Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala 
145                 150                 155                 160 


Ala Lys Ala Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala 
                165                 170                 175     


Asp Leu Phe Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys 
            180                 185                 190         


Tyr Gly Ile Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val 
        195                 200                 205             


Ala Ala Glu Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp 
    210                 215                 220                 


His Ile Arg Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr 
225                 230                 235                 240 


Phe Asn Asp Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp 
                245                 250                 255     


Lys Glu 
        


<210>  6594
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6594
auggauuugg gcggagcagu gacuccgccu uuaauauguc acaaaaagga uaaaacgaug       60

gcuacuccac acauuaaugc agaaaugggc gauuuugcug acguaguuuu gaugccaggc      120

gacccgcugc gugcgaagua uauugcugaa acuuuccuug aagaugcccg ugaagugaac      180

aacguucgcg guaugcuggg cuucacuggu acuuacaaag gccgcaaaau uuccguaaug      240

ggccacggua uggguauccc guccugcucc aucuacacca aagaacugau cacugauuuc      300

ggcgugaaga aaauuauccg cguggguucc uguggcgcug uucugccgca cguaaaacug      360

cgcgacgucg uuaucgguau gggugccugc accgauucca aaguuaaccg cauccguuuu      420

aaagaccaug acuuugccgc uaucgcugac uucgacaugg ugcguaacgc gguagacgcg      480

gcaaaagcac ugggcguuga ugcucgcguu gguaaccugu ucuccgcuga ccuguucuac      540

ucuccggacg gcgaaauguu cgacgugaug gaaaaauacg gcauccucgg cguggaaaug      600

gaagcggcgg guaucuacgg cgucgcugca gaauuuggcg cgaaagcccu gaccaucugc      660

accgugucug accacauccg cacucacgag cagaccacug ccgcugagcg ucagaccacc      720

uucaacgaca ugaucaaaau cgcgcuggaa uccguucugc ugggcgauaa agaguaa         777


<210>  6595
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6595
auggaccugg gcggggccgu gaccccgccc cucaucugcc acaagaagga caagaccaug       60

gccacgcccc acaucaacgc ggagaugggc gacuucgccg acgucgugcu gaugcccggg      120

gacccccugc gcgccaagua caucgccgag accuuccucg aggacgcccg ggaggugaac      180

aacguccgcg gcaugcuggg guucaccggc accuacaagg gccggaagau cagcgugaug      240

gggcacggca uggggauccc guccugcagc aucuacacga aggagcugau caccgacuuc      300

ggcgugaaga agaucauccg cgucgggucc ugcggcgcgg ugcuccccca cgugaagcug      360

cgggacgucg ugaucggcau gggggccugc accgacagca aggugaaccg cauccgguuc      420

aaggaccacg acuucgccgc caucgcggac uucgacaugg uccgcaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgcgcggguc gggaaccucu ucuccgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg gguggagaug      600

gaggccgccg gcaucuacgg ggucgccgcg gaguucggcg ccaaggcccu caccaucugc      660

acgguguccg accacauccg cacccacgag cagaccaccg ccgccgagcg gcagacgacc      720

uucaacgaca ugaucaagau cgcgcuggag agcgugcugc ucggggacaa ggaguga         777


<210>  6596
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6596
auggaccucg gcggcgccgu cacccccccc cucaucugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acgucguccu caugcccggc      120

gacccccucc gcgccaagua caucgccgag accuuccucg aggacgcccg cgaggucaac      180

aacguccgcg gcaugcucgg cuucaccggc accuacaagg gccgcaagau cuccgucaug      240

ggccacggca ugggcauccc cuccugcucc aucuacacca aggagcucau caccgacuuc      300

ggcgucaaga agaucauccg cgucggcucc ugcggcgccg uccuccccca cgucaagcuc      360

cgcgacgucg ucaucggcau gggcgccugc accgacucca aggucaaccg cauccgcuuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg uccgcaacgc cgucgacgcc      480

gccaaggccc ucggcgucga cgcccgcguc ggcaaccucu ucuccgccga ccucuucuac      540

ucccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccucgg cgucgagaug      600

gaggccgccg gcaucuacgg cgucgccgcc gaguucggcg ccaaggcccu caccaucugc      660

accgucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg ccagaccacc      720

uucaacgaca ugaucaagau cgcccucgag uccguccucc ucggcgacaa ggaguga         777


<210>  6597
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6597
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaccaug       60

gcuacuccac auauuaacgc agagauggga gacuucgccg augucguucu uaugccgggu      120

gacccccuga gagcgaaaua cauagcugaa acguuuuugg aggaugccag ggaagugaau      180

aacguacggg gcauguuagg guucaccgga acauauaagg gccgcaaaau cagcgugaug      240

ggucacggga ugggcauucc uuccuguucu aucuacacua aggagcugau uaccgacuuu      300

ggagucaaga aaaucauacg agugggcuca ugcggggcag uucuaccaca ugugaagcuc      360

cgugaugucg ugaucggaau gggugccugu acagacagua aaguaaauag aauuagguuc      420

aaggaucacg acuuugcugc aaucgccgau uucgacaugg uucggaacgc uguggaugcc      480

gcgaaagcac ugggcgucga cgcccgcgug gggaaucuuu uuagcgcuga ccuguucuau      540

ucccccgaug gagaaauguu ugacgugaug gagaaguacg gcauuuuggg ugucgagaug      600

gaagccgcag ggaucuaugg aguugcugcc gaguucggcg cgaaggcccu caccauaugc      660

acugugucug aucauauuag aacacacgaa cagaccacgg cagcugagag gcaaacuacc      720

uuuaacgaca ugaucaaaau ugcccuggag ucgguacugc ucggcgauaa ggaauga         777


<210>  6598
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6598
auggaccugg gcggcgccgu gacccccccc cugaucugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acguggugcu gaugcccggc      120

gacccccuga gagccaagua caucgccgag accuuccugg aggacgccag agaggugaac      180

aacgugagag gcaugcuggg cuucaccggc accuacaagg gcagaaagau cagcgugaug      240

ggccacggca ugggcauccc cagcugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucaucag agugggcagc ugcggcgccg ugcugcccca cgugaagcug      360

agagacgugg ugaucggcau gggcgccugc accgacagca aggugaacag aaucagauuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg ugagaaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgccagagug ggcaaccugu ucagcgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg cguggagaug      600

gaggccgccg gcaucuacgg cguggccgcc gaguucggcg ccaaggcccu gaccaucugc      660

accgugagcg accacaucag aacccacgag cagaccaccg ccgccgagag acagaccacc      720

uucaacgaca ugaucaagau cgcccuggag agcgugcugc ugggcgacaa ggaguga         777


<210>  6599
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6599
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaccaug       60

gcuacgccgc auauuaacgc cgagauggga gacuucgcgg augucguucu gaugcccggc      120

gacccucuua gagcuaaaua caucgccgaa accuuucugg aggaugcccg ggaagugaau      180

aacgugcgcg ggaugcucgg auucacaggc accuauaagg ggagaaaaau uagcgucaug      240

ggacacggca ugggcauccc cuccuguucu auuuacacaa aggagcugau caccgacuuu      300

ggggugaaga aaaucauucg gguuggaagc ugcggcgcug ugcuuccuca ugucaagcug      360

cgcgaugugg uuaucgggau gggagccugu acagacucca aagugaaucg gauuagauuc      420

aaggaucacg acuuugcugc caucgcggau uucgacaugg uccgcaacgc cguggaugcu      480

gccaaagcuc ucggcgugga cgccagaguc gggaaucugu uuucugcgga ccuguucuau      540

agccccgaug gagaaauguu ugacguuaug gagaaguacg gcauucucgg cguggagaug      600

gaagccgcug ggaucuaugg aguggccgcu gaguucggcg ccaaggcccu gaccauuugc      660

acggucuccg aucauauccg gacccacgaa cagacaaccg cugcggagcg ccaaacaacc      720

uuuaacgaca ugaucaaaau ugcccuugag ucugugcugc ucggggauaa ggaauga         777


<210>  6600
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI17958

<400>  6600
auggaucuag gaggagcagu aacaccacca uuaauaugcc auaaaaaaga caaaacuaug       60

gcaacaccac auauaaaugc agaaauggga gacuuugcag auguaguauu aaugccagga      120

gacccacuaa gagcaaaaua cauagcagaa acauuucuag aagacgcaag agaaguaaau      180

aacguaagag gaaugcuagg auuuacagga acuuauaaag gaagaaaaau aucaguaaug      240

ggacauggaa ugggaauacc aucaugcucg auauauacaa aagaauuaau aacagauuuu      300

ggaguaaaaa aaauaauaag aguaggauca ugcggagcag uacuaccuca uguaaaacua      360

agagauguag uaauaggaau gggagcaugu acagauagua aaguaaauag aauaagguuu      420

aaagaucacg acuucgcagc aauagcagau uucgauaugg uuagaaaugc aguugaugca      480

gcaaaagccu uaggaguaga cgcaagagua ggaaauuuau uuagugcaga cuuauucuau      540

aguccagacg gagaaauguu cgacguaaug gaaaaauacg gaauauuagg aguagaaaug      600

gaagcagcag gaauauaugg aguagcagca gaauuuggag caaaagcacu uacuauuugu      660

acaguaagcg aucacauaag aacacaugaa caaacaacag cagcagaaag acaaacaacg      720

uucaaugaca ugauaaaaau agcauuagaa agcguauuau uaggagauaa agaauaa         777


<210>  6601
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4T9F1

<400>  6601

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6602
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6602
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aauugcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6603
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6603
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6604
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6604
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6605
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6605
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6606
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6606
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6607
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6607
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6608
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI23374

<400>  6608
auggcaacac cacauauaaa ugcggaaaug ggagacuuug ccgauguagu auuaaugcca       60

ggagacccau uaagggcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu gggauuuaca ggaacauaua aaggaaggaa aauaagugua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaacu aauaacagau      240

uuuggaguaa aaaaaauaau aagaguagga ucauguggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gacuucgaua ugguaagaaa ugcaguagac      420

gcagccaaag cauuaggaau agacgcaaga guaggaaauu uauuuagcgc agacuuauuc      480

uauaguccug acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguga gcgaucacau uagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauuuaaug acaugauaaa aauagcauua gaaaguguau uauuaggaga uaaagaauaa      720


<210>  6609
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4UXB7

<400>  6609

Met Asp Leu Gly Gly Ala Leu Thr Pro Pro Leu Leu Cys His Lys Lys 
1               5                   10                  15      


Asp Lys Thr Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe 
            20                  25                  30          


Ala Asp Val Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile 
        35                  40                  45              


Ala Glu Thr Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly 
    50                  55                  60                  


Met Leu Gly Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met 
65                  70                  75                  80  


Gly His Gly Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu 
                85                  90                  95      


Ile Thr Asp Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly 
            100                 105                 110         


Ala Val Leu Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly 
        115                 120                 125             


Ala Cys Thr Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp 
    130                 135                 140                 


Phe Ala Ala Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala 
145                 150                 155                 160 


Ala Lys Ala Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala 
                165                 170                 175     


Asp Leu Phe Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys 
            180                 185                 190         


Tyr Gly Ile Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val 
        195                 200                 205             


Ala Ala Glu Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp 
    210                 215                 220                 


His Ile Arg Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr 
225                 230                 235                 240 


Phe Asn Asp Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp 
                245                 250                 255     


Lys Glu 
        


<210>  6610
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6610
auggauuugg gcggagcguu gacuccgccu uuguuauguc acaaaaagga uaaaacaaug       60

gcuaccccac acauuaaugc agaaaugggc gauuucgcug acguaguuuu gaugccaggc      120

gacccgcugc gugcgaagua uauugcugaa acuuuccuug aagaugcccg ugaagugaau      180

aacguucgcg guaugcuggg cuucacuggu acuuacaaag gccgcaaaau uuccguaaug      240

ggucacggua uggguauccc guccugcucc aucuacacca aagaacugau caccgauuuc      300

ggcgugaaga aaauuauccg cguaggcucc uguggcgcug uucuaccaca cguaaaacug      360

cgcgacgucg uuaucgguau gggugccugc accgauucca aaguuaaccg uauccguuuu      420

aaagaccaug acuuugccgc uaucgcugac uuugacaugg ugcguaacgc gguagacgcg      480

gcuaaagcac ugggcguuga ugcucgcguu gguaaccugu ucuccgcuga ccuguucuac      540

ucuccggacg gcgaaauguu cgacgugaug gaaaaauacg gcauccucgg cguggaaaug      600

gaagcagcug guaucuacgg cgucgcugca gaauuuggcg cgaaagcccu gaccaucugc      660

accgugucug accacauccg cacucacgag cagaccacug ccgcugagcg ucagaccacc      720

uucaacgaca ugaucaaaau cgcacuggaa uccguucugu ugggcgauaa agaguaa         777


<210>  6611
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6611
auggaccugg gcggggcccu caccccgccc cugcugugcc acaagaagga caagaccaug       60

gccacgcccc acaucaacgc ggagaugggc gacuucgccg acgugguccu caugcccggg      120

gacccccugc gcgccaagua caucgccgag accuuccugg aggacgcccg ggaggugaac      180

aacgugcgcg gcaugcucgg guucaccggc accuacaagg gccggaagau cagcgucaug      240

gggcacggca uggggauccc guccugcagc aucuacacga aggagcugau caccgacuuc      300

ggcgugaaga agaucauccg cguggggucc ugcggcgcgg uccugcccca cgugaagcuc      360

cgggacgugg ucaucggcau gggggccugc accgacagca aggugaaccg cauccgguuc      420

aaggaccacg acuucgccgc caucgcggac uucgacaugg ugcgcaacgc cgucgacgcc      480

gccaaggccc ugggcgugga cgcgcgggug gggaaccugu ucuccgccga ccucuucuac      540

agccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccuggg gguggagaug      600

gaggccgccg gcaucuacgg gguggccgcg gaguucggcg ccaaggcccu gaccaucugc      660

acggucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg gcagacgacc      720

uucaacgaca ugaucaagau cgcgcucgag agcgugcugc ugggggacaa ggaguga         777


<210>  6612
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6612
auggaccucg gcggcgcccu cacccccccc cuccucugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acgucguccu caugcccggc      120

gacccccucc gcgccaagua caucgccgag accuuccucg aggacgcccg cgaggucaac      180

aacguccgcg gcaugcucgg cuucaccggc accuacaagg gccgcaagau cuccgucaug      240

ggccacggca ugggcauccc cuccugcucc aucuacacca aggagcucau caccgacuuc      300

ggcgucaaga agaucauccg cgucggcucc ugcggcgccg uccuccccca cgucaagcuc      360

cgcgacgucg ucaucggcau gggcgccugc accgacucca aggucaaccg cauccgcuuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg uccgcaacgc cgucgacgcc      480

gccaaggccc ucggcgucga cgcccgcguc ggcaaccucu ucuccgccga ccucuucuac      540

ucccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccucgg cgucgagaug      600

gaggccgccg gcaucuacgg cgucgccgcc gaguucggcg ccaaggcccu caccaucugc      660

accgucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg ccagaccacc      720

uucaacgaca ugaucaagau cgcccucgag uccguccucc ucggcgacaa ggaguga         777


<210>  6613
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6613
auggaccugg gcggggcccu cacacccccu cuucugugcc acaagaaaga uaagaccaug       60

gcuacuccac auaucaacgc agagauggga gacuucgccg auguggucuu gaugccgggu      120

gaccccuuaa gagcgaaaua cauugcugaa acguuucugg aggaugccag ggaaguuaau      180

aacgugcggg gcaugcuagg guucaccgga acauauaagg gccgcaaaau aagcguaaug      240

ggucacggga ugggaauccc uuccuguucu auuuacacua aggagcucau caccgacuuu      300

ggcgugaaga aaauuauccg agucggcuca ugcggggcag ugcugccaca uguuaaacuu      360

cgugaugugg ucauaggaau gggugccugu acagacagua aggugaauag aaucagguuc      420

aaggaucacg acuuugcugc aauugccgau uucgacaugg uacggaacgc uguugaugcc      480

gcgaaagcac ugggcgugga cgcccgcguc gggaauuugu uuagcgcuga ccucuucuau      540

ucccccgaug gagaaauguu ugacgugaug gagaaguacg gcauccuggg uguggagaug      600

gaagccgcag ggauuuaugg agucgcugcc gaguucggcg cgaaggcccu gaccaucugc      660

acuguuucug aucauauaag aacacacgaa cagaccacgg cagcugagag gcaaacuacc      720

uuuaacgaca ugauuaaaau cgcccucgag ucgguguuac ugggcgauaa ggaauga         777


<210>  6614
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6614
auggaccugg gcggcgcccu gacccccccc cugcugugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acguggugcu gaugcccggc      120

gacccccuga gagccaagua caucgccgag accuuccugg aggacgccag agaggugaac      180

aacgugagag gcaugcuggg cuucaccggc accuacaagg gcagaaagau cagcgugaug      240

ggccacggca ugggcauccc cagcugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucaucag agugggcagc ugcggcgccg ugcugcccca cgugaagcug      360

agagacgugg ugaucggcau gggcgccugc accgacagca aggugaacag aaucagauuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg ugagaaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgccagagug ggcaaccugu ucagcgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg cguggagaug      600

gaggccgccg gcaucuacgg cguggccgcc gaguucggcg ccaaggcccu gaccaucugc      660

accgugagcg accacaucag aacccacgag cagaccaccg ccgccgagag acagaccacc      720

uucaacgaca ugaucaagau cgcccuggag agcgugcugc ugggcgacaa ggaguga         777


<210>  6615
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6615
auggaccugg gcggggcccu cacacccccu cugcuuugcc acaagaaaga uaagaccaug       60

gcuacgccgc auaucaacgc cgagauggga gacuucgcgg augugguccu gaugcccggc      120

gacccucuca gagcuaaaua cauugccgaa accuuucugg aggaugcccg ggaaguuaau      180

aacgugcgcg ggaugcuugg auucacaggc accuauaagg ggagaaaaau cagcgugaug      240

ggacacggca ugggcauucc cuccuguucu aucuacacaa aggagcugau uaccgacuuu      300

ggggucaaga aaaucauccg ggugggaagc ugcggcgcug uucucccuca ugugaagcug      360

cgcgaugucg ugauugggau gggagccugu acagacucca aaguuaauag aauccgguuc      420

aaggaucacg acuuugcugc cauugcggau uucgacaugg ugcgcaacgc cgucgaugcu      480

gccaaagcuc ugggcgugga cgccagagug gggaaucucu uuucugcgga ccuguucuau      540

agccccgaug gagaaauguu ugacgucaug gagaaguacg gcauccuugg cguugagaug      600

gaagccgcug ggauuuaugg aguggccgcu gaguucggcg ccaaggcccu gaccaucugc      660

acgguguccg aucauauucg gacccacgaa cagacaaccg cugcggagcg ccaaacaacc      720

uuuaacgaca ugaucaaaau cgcccucgag ucuguccugc uuggggauaa ggaauga         777


<210>  6616
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI42706

<400>  6616
auggaccuag gaggagcacu aacaccacca cuauuaugcc auaaaaaaga caaaacaaug       60

gcaacaccac auauaaaugc agaaauggga gacuuugcag auguaguacu aaugccagga      120

gacccacuaa gagcaaaaua cauagccgaa acauuucuag aagacgcaag agaaguaaau      180

aacguaagag gaauguuagg auuuacaggg acauauaaag gaagaaaaau aaguguaaug      240

ggacauggaa ugggaauacc aucaugcagu auauauacaa aagaauuaau aacggacuuu      300

ggaguaaaaa agaucauaag aguaggcuca ugcggagcag uacuaccaca uguaaaauua      360

agagauguag uaauaggaau gggagcaugu accgauucaa aagucaauag aauaagauuu      420

aaagaucacg auuucgcggc aauagcagac uuugauaugg uaagaaaugc aguagacgca      480

gcaaaagcau uaggaguaga cgcaagagua ggaaaucuau uuagcgcaga cuuauucuau      540

agcccagacg gagaaauguu cgauguaaug gaaaaauacg gaauauuagg aguagaaaug      600

gaagcggcag gaauauaugg aguagcagca gaauuuggag caaaagcauu aacaauaugu      660

acaguaagcg aucacauaag aacacacgaa caaacaacag cugcagaaag acaaacaaca      720

uucaaugaca ugauaaaaau agcacuagaa agcguacuac uaggagauaa agaauaa         777


<210>  6617
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4VN60

<400>  6617

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6618
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6618
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcaaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaua aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6619
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6619
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6620
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6620
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6621
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6621
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6622
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6622
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6623
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6623
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6624
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI43348

<400>  6624
auggcaacac cacauauuaa ugcagaaaug ggagacuuug cagauguagu acuaaugcca       60

ggagacccau uaagagcaaa auauauagca gaaacauuuu uagaagacgc aagagaagua      120

aauaacguaa gagggauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaaguugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaagauaau aagaguagga ucaugcggag caguauuacc acacguaaaa      300

uuaagagaug uagugauagg aaugggagca uguacagaua guaaagucaa ucgaauaaga      360

uucaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agaugcaaga guaggaaauc uauuuucagc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau acggaauacu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acucacaaua      600

uguacaguaa gcgaucacau aagaacgcac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaacg acaugauaaa aauagcauua gaaagcguac uacuaggaga caaagaauaa      720


<210>  6625
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__F4VQF8

<400>  6625

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6626
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6626
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagccg cuggcaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6627
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6627
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6628
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6628
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6629
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6629
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6630
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6630
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6631
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6631
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6632
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__EGI52751

<400>  6632
auggcaacac cacauauaaa ugcagaaaug ggagacuuug ccgauguagu gcuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaauguu aggauuuaca ggaaccuaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugu ucaauauaua caaaagaauu gauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga ucaugcggag caguauuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggagca uguaccgaca gcaaaguaaa uagaauaaga      360

uuuaaagauc augauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcggcaaaag cauuaggagu agacgcaaga guaggaaacc uauuuagcgc agacuuguuu      480

uauagcccag acggagaaau guuugaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc guuaacaaua      600

uguacaguaa gugaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa gauagcacua gaaagcguac uauugggaga uaaagaauaa      720


<210>  6633
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__H9V0H4

<400>  6633

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6634
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6634
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcguaggc uccuguggcg cuguucugcc acacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccguauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcag cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc uguugggcga uaaagaguaa      720


<210>  6635
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6635
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6636
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6636
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6637
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6637
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6638
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6638
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6639
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6639
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6640
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AFG43267

<400>  6640
auggcaacac cacauauuaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggggacccau uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aacaauguaa gaggaauguu aggauuuaca ggaacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugc ucaauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguugga ucaugcggag caguacuacc acacguaaaa      300

uuaagagaug uaguaauagg aaugggggca uguacagaua gcaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agcaauagca gauuucgaua ugguacgaaa ugccguggac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauauu aggaguagaa      540

auggaagcag caggaauaua cggaguagca gcagaauuug gagcaaaagc gcuaacaaua      600

ugcacaguaa gugaucacau aagaacgcac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguau uauuaggcga uaaagaauaa      720


<210>  6641
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__J7QV83

<400>  6641

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6642
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6642
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagauc augacuuugc cgcuaucgcu gacuuugaca uggugcguaa cgcgguagac      420

gcggcuaaag cacugggcau ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

uguaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6643
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6643
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6644
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6644
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6645
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6645
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6646
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6646
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6647
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6647
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6648
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CCK49767

<400>  6648
auggcaacac cacauauaaa ugcugaaaug ggagauuuug cagauguagu acugaugcca       60

ggugauccac uaagagcaaa auacauagca gaaacauuuu uagaagacgc aagagaagug      120

aauaacguaa gaggaauguu gggauuuaca gggacauaua aaggaagaaa aauaucagua      180

augggacaug gaaugggaau accaucaugu aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguagga aguugcggag caguauuacc acacguaaaa      300

uuaagagaug ucguaauagg aaugggagca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuuugc agccauagca gauuuugaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaaga guaggaaauu uauuuagugc agacuuauuc      480

uauaguccag acggagaaau guucgaugua auggaaaaau acggaauacu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcauua gaaagcguac uauuaggaga uaaagaauaa      720


<210>  6649
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__P0ABP8

<400>  6649

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Ile Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6650
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6650
auggcuaccc cacacauuaa ugcagaaaug ggcgauuucg cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacc gguacuuaca aaggccgcaa aauuuccgua      180

augggucacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucaccgau      240

uucggcguga agaaaauuau ccgcgugggu uccuguggcg caguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcaguagau      420

gcagcuaaag cacuggguau ugaugcucgc guggguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauucu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccguau cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacu      660

accuucaacg acaugaucaa aaucgcacug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6651
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6651
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcau cgacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacgug auggagaagu acgggauccu cggcgucgag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgugu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgucc uccuggggga caaggaguga      720


<210>  6652
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6652
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcau cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6653
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6653
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggaau cgacgcacgc guggguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacguc auggagaaau acgggauucu uggaguggag      540

auggaagcug ccggcaucua ugguguggca gcugaguucg gggccaaggc gcugaccaua      600

uguacagucu cugaucacau uagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugaucaa aauugcuuug gagucgguuc uccugggaga uaaggaauga      720


<210>  6654
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6654
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcau cgacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6655
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6655
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuugggau cgacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacgug auggagaaau acgggauucu gggagucgag      540

auggaagcgg ccggcaucua uggcguugcu gccgaguucg gggcuaaggc ccugaccauu      600

uguacagugu ccgaucacau ccggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aauugcgcuc gagucugugc ugcuuggaga uaaggaauga      720


<210>  6656
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AAA24401

<400>  6656
auggcaacac cacauauaaa ugcagaaaug ggggacuuug cagauguagu auuaaugccu       60

ggggacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaauguaa gaggaauguu aggauuuaca ggaacauaua aaggacgaaa aauaucagua      180

augggccaug gaaugggaau acccucaugc aguauauaua caaaagaauu aauaacagac      240

uuuggaguaa aaaaaaucau aagaguagga agcugcggag caguacuacc gcacguaaaa      300

cuacgagaug uaguaauagg aaugggggca uguacagaua guaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcaguagac      420

gcagcaaaag cauuaggaau agacgcaagg guaggaaauu uauuuagcgc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau auggaauacu aggaguagaa      540

auggaagcag caggaauaua uggaguagca gcagaauuug gugcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa cagcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaagcguau uauuaggaga uaaagaauaa      720


<210>  6657
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__Q0T8S9

<400>  6657

Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210>  6658
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6658
auggcuacuc cacacauuaa ugcagaaaug ggcgauuuug cugacguagu uuugaugcca       60

ggcgacccgc ugcgugcgaa guauauugcu gaaacuuucc uugaagaugc ccgugaagug      120

aacaacguuc gcgguaugcu gggcuucacu gguacuuaca aaggccgcaa aauuuccgua      180

augggccacg guauggguau cccguccugc uccaucuaca ccaaagaacu gaucacugau      240

uucggcguga agaaaauuau ccgcguuggu uccuguggcg cuguucugcc gcacguaaaa      300

cugcgcgacg ucguuaucgg uaugggugcc ugcaccgauu ccaaaguuaa ccgcauccgu      360

uuuaaagacc augacuuugc cgcuaucgcu gacuucgaca uggugcguaa cgcgguagac      420

gcggcaaaag cacugggcgu ugaugcucgc guugguaacc uguucuccgc ugaccuguuc      480

uacucuccgg acggcgaaau guucgacgug auggaaaaau acggcauccu cggcguggaa      540

auggaagcgg cugguaucua cggcgucgcu gcagaauuug gcgcgaaagc ccugaccauc      600

ugcaccgugu cugaccacau ccgcacucac gagcagacca cugccgcuga gcgucagacc      660

accuucaacg acaugaucaa aaucgcgcug gaauccguuc ugcugggcga uaaagaguaa      720


<210>  6659
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6659
auggccacgc cccacaucaa cgccgagaug ggcgacuucg cggacguggu ccugaugccg       60

ggggaccccc uccgcgccaa guacaucgcc gagaccuucc uggaggacgc ccgggaggug      120

aacaacgugc gcggcaugcu gggguucacc ggcaccuaca aggggcggaa gaucagcguc      180

augggccacg gcauggggau ccccuccugc agcaucuaca ccaaggagcu caucaccgac      240

uucggcguga agaagaucau ccgcgugggg uccugcggcg ccguccugcc ccacgugaag      300

cugcgggacg uggucaucgg gaugggcgcg ugcacggaca gcaaggugaa ccgcauccgg      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugcgcaa cgcggucgac      420

gccgccaagg cccucggcgu ggacgcccgg guggggaacc uguucuccgc ggaccuguuc      480

uacagcccgg acggcgagau guucgacguc auggagaagu acgggauccu cggcguggag      540

auggaggccg ccggcaucua cgggguggcc gccgaguucg gcgcgaaggc ccugaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacga ccgccgccga gcggcagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc uccuggggga caaggaguga      720


<210>  6660
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6660
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacgucgu ccucaugccc       60

ggcgaccccc uccgcgccaa guacaucgcc gagaccuucc ucgaggacgc ccgcgagguc      120

aacaacgucc gcggcaugcu cggcuucacc ggcaccuaca agggccgcaa gaucuccguc      180

augggccacg gcaugggcau ccccuccugc uccaucuaca ccaaggagcu caucaccgac      240

uucggcguca agaagaucau ccgcgucggc uccugcggcg ccguccuccc ccacgucaag      300

cuccgcgacg ucgucaucgg caugggcgcc ugcaccgacu ccaaggucaa ccgcauccgc      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca ugguccgcaa cgccgucgac      420

gccgccaagg cccucggcgu cgacgcccgc gucggcaacc ucuucuccgc cgaccucuuc      480

uacucccccg acggcgagau guucgacguc auggagaagu acggcauccu cggcgucgag      540

auggaggccg ccggcaucua cggcgucgcc gccgaguucg gcgccaaggc ccucaccauc      600

ugcaccgucu ccgaccacau ccgcacccac gagcagacca ccgccgccga gcgccagacc      660

accuucaacg acaugaucaa gaucgcccuc gaguccgucc uccucggcga caaggaguga      720


<210>  6661
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6661
auggccacac cccacaucaa cgcugagaug ggcgacuucg cagauguggu ccugaugccu       60

ggggacccac ucagagccaa guacauugcg gaaaccuuuc uugaggaugc uagggaaguu      120

aauaacgugc ggggaaugcu ggguuucacu ggcacguaua aagggcgcaa gauaagcgua      180

augggacaug gcauggguau cccguccugc ucuauuuaca ccaaagaguu gaucacagac      240

uuugggguga agaaaauuau ccgagucgga ucauguggcg ccguguuacc ccacguuaag      300

cugcgugaug uggucauagg caugggggca ugcacugaca guaaggugaa uagaaucagg      360

uucaaagauc augacuuugc cgcuauugca gauuucgaca ugguacggaa cgccguugau      420

gcugccaagg cgcuaggagu ggacgcacgc gucgguaauc ucuuuagcgc cgaucuguuc      480

uauuccccug acggcgaaau guuugacgug auggagaaau acgggauccu uggaguggag      540

auggaagcug ccggcauuua uggugucgca gcugaguucg gggccaaggc gcugaccauc      600

uguacaguuu cugaucacau aagaacccau gaacagacua cagccgcaga gaggcaaacc      660

acguuuaacg acaugauuaa aaucgcuuug gagucggugc uccugggaga uaaggaauga      720


<210>  6662
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6662
auggccaccc cccacaucaa cgccgagaug ggcgacuucg ccgacguggu gcugaugccc       60

ggcgaccccc ugagagccaa guacaucgcc gagaccuucc uggaggacgc cagagaggug      120

aacaacguga gaggcaugcu gggcuucacc ggcaccuaca agggcagaaa gaucagcgug      180

augggccacg gcaugggcau ccccagcugc agcaucuaca ccaaggagcu gaucaccgac      240

uucggcguga agaagaucau cagagugggc agcugcggcg ccgugcugcc ccacgugaag      300

cugagagacg uggugaucgg caugggcgcc ugcaccgaca gcaaggugaa cagaaucaga      360

uucaaggacc acgacuucgc cgccaucgcc gacuucgaca uggugagaaa cgccguggac      420

gccgccaagg cccugggcgu ggacgccaga gugggcaacc uguucagcgc cgaccuguuc      480

uacagccccg acggcgagau guucgacgug auggagaagu acggcauccu gggcguggag      540

auggaggccg ccggcaucua cggcguggcc gccgaguucg gcgccaaggc ccugaccauc      600

ugcaccguga gcgaccacau cagaacccac gagcagacca ccgccgccga gagacagacc      660

accuucaacg acaugaucaa gaucgcccug gagagcgugc ugcugggcga caaggaguga      720


<210>  6663
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6663
auggccacac cccacaucaa cgcugagaug ggcgacuucg ccgauguggu ccugaugccu       60

ggggacccgc ucagagcgaa guacauugcu gaaaccuuuc uggaggaugc ccgggaaguu      120

aauaacgugc gcggaaugcu uggcuucacg gggaccuaua aaggaagaaa gaucagcgug      180

augggccaug ggaugggcau ucccuccugc ucuaucuaca caaaagagcu gauuaccgac      240

uuuggaguca agaaaaucau ccgggugggc agcugugggg ccguucuccc ucacgugaag      300

cugcgcgaug ucgugauugg aaugggcgcu ugcacagacu ccaagguuaa uagaauccgg      360

uucaaagauc augacuuugc cgcuauugcc gauuucgaca uggugcgcaa cgcggucgau      420

gccgcuaagg cccuuggggu ggacgcuaga gugggaaauc uguuuucugc cgaucucuuc      480

uauagccccg acggcgaaau guuugacguc auggagaaau acgggauccu gggaguugag      540

auggaagcgg ccggcauuua uggcguggcu gccgaguucg gggcuaaggc ccugaccauc      600

uguacagugu ccgaucacau ucggacccau gaacagacga ccgccgcuga gcgccaaaca      660

accuuuaacg acaugaucaa aaucgcgcuc gagucugucc ugcuuggaga uaaggaauga      720


<210>  6664
<211>  720
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABG72650

<400>  6664
auggcaacac cacauauaaa ugcagaaaug ggagacuuug cagauguagu auuaaugcca       60

ggagacccac uaagagcaaa auacauagca gaaacauuuc uagaagacgc aagagaagua      120

aauaacguaa gaggaaugcu aggauuuaca ggaacauaua aaggaagaaa aauaucaguc      180

augggacaug gaaugggaau accaucaugc ucaauauaca ccaaagaauu aauaacagac      240

uuuggaguaa aaaaaauaau aagaguaggc aguugcggag caguacuacc acacguaaaa      300

uuacgagaug ucguaauagg aaugggagca uguacagauu caaaaguaaa uagaauaaga      360

uuuaaagauc acgauuucgc agcaauagca gauuucgaua ugguaagaaa ugcuguagac      420

gcagcaaaag cauuaggagu agacgcaaga guaggaaauc uauuuagcgc agacuuauuc      480

uauagcccag acggagaaau guucgaugua auggaaaaau auggaauauu aggaguagaa      540

auggaagcag caggaauaua uggaguagcc gcagaauuug gagcaaaagc acuaacaaua      600

uguacaguaa gcgaucacau aagaacacac gaacaaacaa ccgcagcaga aagacaaaca      660

acauucaaug acaugauaaa aauagcacua gaaaguguac uauugggaga uaaagaauga      720


<210>  6665
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__Q1R259

<400>  6665

Met Asp Leu Gly Gly Ala Val Thr Pro Pro Leu Ile Cys His Lys Lys 
1               5                   10                  15      


Asp Lys Met Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe 
            20                  25                  30          


Ala Asp Val Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile 
        35                  40                  45              


Ala Glu Thr Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly 
    50                  55                  60                  


Met Leu Gly Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met 
65                  70                  75                  80  


Gly His Gly Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu 
                85                  90                  95      


Ile Thr Asp Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly 
            100                 105                 110         


Ala Val Leu Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly 
        115                 120                 125             


Ala Cys Thr Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp 
    130                 135                 140                 


Phe Ala Ala Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala 
145                 150                 155                 160 


Ala Lys Ala Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala 
                165                 170                 175     


Asp Leu Phe Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys 
            180                 185                 190         


Tyr Gly Ile Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val 
        195                 200                 205             


Ala Ala Glu Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp 
    210                 215                 220                 


His Ile Arg Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr 
225                 230                 235                 240 


Phe Asn Asp Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp 
                245                 250                 255     


Lys Glu 
        


<210>  6666
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6666
auggauuugg gcggagcagu gacuccgccu uuaauauguc acaaaaagga uaaaaugaug       60

gcuacuccac acauuaaugc agaaaugggc gauuuugcug acguaguuuu gaugccaggu      120

gacccgcugc gugcgaagua uauugcugaa acuuuccuug aagaugcccg ugaagugaac      180

aacguucgcg guaugcuggg cuucacuggu acuuacaaag gccgcaaaau uuccguaaug      240

ggccacggua uggguauccc guccugcucc aucuacacca aagaacugau cacugauuuc      300

ggcgugaaga aaauuauccg cguugguucc uguggcgcug uucugccgca cguaaaacug      360

cgcgacgucg uuaucgguau gggugccugc accgauucca aaguuaaccg cauccguuuu      420

aaagaccaug acuuugccgc uaucgcugac uucgacaugg ugcguaacgc gguagacgcg      480

gcaaaagcac ugggcguuga ugcucguguu gguaaccugu ucuccgcuga ccuguucuac      540

ucuccggacg gcgaaauguu cgacgugaug gaaaaauacg gcauccucgg cguggaaaug      600

gaagcggcug guaucuacgg cgucgcugca gaauuuggcg cgaaagcccu gaccaucugc      660

accgugucug accacauccg cacucacgag cagaccacug ccgcugagcg ucagaccacc      720

uucaacgaca ugaucaaaau cgcgcuggaa uccguucugc ugggcgauaa agaguaa         777


<210>  6667
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6667
auggaccugg gcggggccgu gacgcccccg cucaucugcc acaagaagga caagaugaug       60

gccacgcccc acaucaacgc ggagaugggc gacuucgccg acgucgugcu gaugcccggg      120

gacccccugc gcgccaagua caucgccgag accuuccucg aggacgcccg ggaggugaac      180

aacguccgcg gcaugcuggg guucaccggc accuacaagg gccggaagau cagcgugaug      240

gggcacggca uggggauccc guccugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucauccg cgucgggucc ugcggcgcgg ugcuccccca cgugaagcug      360

cgggacgucg ugaucggcau gggggccugc accgacagca aggugaaccg cauccgguuc      420

aaggaccacg acuucgccgc caucgcggac uucgacaugg uccgcaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgcgcggguc gggaaccucu ucuccgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg gguggagaug      600

gaggccgccg gcaucuacgg ggucgccgcg gaguucggcg ccaaggcccu caccaucugc      660

accguguccg accacauccg cacgcacgag cagaccaccg ccgccgagcg gcagaccacg      720

uucaacgaca ugaucaagau cgcgcuggag agcgugcugc ucggggacaa ggaguga         777


<210>  6668
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6668
auggaccucg gcggcgccgu cacccccccc cucaucugcc acaagaagga caagaugaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acgucguccu caugcccggc      120

gacccccucc gcgccaagua caucgccgag accuuccucg aggacgcccg cgaggucaac      180

aacguccgcg gcaugcucgg cuucaccggc accuacaagg gccgcaagau cuccgucaug      240

ggccacggca ugggcauccc cuccugcucc aucuacacca aggagcucau caccgacuuc      300

ggcgucaaga agaucauccg cgucggcucc ugcggcgccg uccuccccca cgucaagcuc      360

cgcgacgucg ucaucggcau gggcgccugc accgacucca aggucaaccg cauccgcuuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg uccgcaacgc cgucgacgcc      480

gccaaggccc ucggcgucga cgcccgcguc ggcaaccucu ucuccgccga ccucuucuac      540

ucccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccucgg cgucgagaug      600

gaggccgccg gcaucuacgg cgucgccgcc gaguucggcg ccaaggcccu caccaucugc      660

accgucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg ccagaccacc      720

uucaacgaca ugaucaagau cgcccucgag uccguccucc ucggcgacaa ggaguga         777


<210>  6669
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6669
auggaccugg gcggggccgu gacucccccu cucaucugcc acaagaaaga uaagaugaug       60

gcuacaccac auauuaacgc agagauggga gacuucgccg augucguucu uaugccgggu      120

gacccccuga gagcgaaaua cauagcugaa accuuuuugg aggaugccag ggaagugaau      180

aacguacggg gcauguuagg guucacggga accuauaagg gccgcaaaau cagcgugaug      240

ggucacggga ugggcauucc uuccuguucu aucuacacaa aggagcugau uacugacuuu      300

ggagucaaga aaaucauacg agugggcuca ugcggggcag uucuaccaca ugugaagcuc      360

cgugaugucg ugaucggaau gggugccugu accgacagua aaguaaauag aauuagguuc      420

aaggaucacg acuuugcugc aaucgccgau uucgacaugg uucggaacgc uguggaugcc      480

gcgaaagcac ugggcgucga cgcccgcgug gggaaucuuu uuagcgcuga ccuguucuau      540

ucccccgaug gagaaauguu ugacgugaug gagaaguacg gcauuuuggg ugucgagaug      600

gaagccgcag ggaucuaugg aguugcugcc gaguucggcg cgaaggcccu cacaauaugc      660

accgugucug aucauauuag aacucacgaa cagacaaccg cagcugagag gcaaacgacu      720

uuuaacgaca ugaucaaaau ugcccuggag ucgguacugc ucggcgauaa ggaauga         777


<210>  6670
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6670
auggaccugg gcggcgccgu gacccccccc cugaucugcc acaagaagga caagaugaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acguggugcu gaugcccggc      120

gacccccuga gagccaagua caucgccgag accuuccugg aggacgccag agaggugaac      180

aacgugagag gcaugcuggg cuucaccggc accuacaagg gcagaaagau cagcgugaug      240

ggccacggca ugggcauccc cagcugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucaucag agugggcagc ugcggcgccg ugcugcccca cgugaagcug      360

agagacgugg ugaucggcau gggcgccugc accgacagca aggugaacag aaucagauuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg ugagaaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgccagagug ggcaaccugu ucagcgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg cguggagaug      600

gaggccgccg gcaucuacgg cguggccgcc gaguucggcg ccaaggcccu gaccaucugc      660

accgugagcg accacaucag aacccacgag cagaccaccg ccgccgagag acagaccacc      720

uucaacgaca ugaucaagau cgcccuggag agcgugcugc ugggcgacaa ggaguga         777


<210>  6671
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6671
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaugaug       60

gcuaccccgc auauuaacgc cgagauggga gacuucgcgg augucguucu gaugcccggc      120

gacccucuua gagcuaaaua caucgccgaa acguuucugg aggaugcccg ggaagugaau      180

aacgugcgcg ggaugcucgg auucaccggc acauauaagg ggagaaaaau uagcgucaug      240

ggacacggca ugggcauccc cuccuguucu auuuacacca aggagcugau cacagacuuu      300

ggggugaaga aaaucauucg gguuggaagc ugcggcgcug ugcuuccuca ugucaagcug      360

cgcgaugugg uuaucgggau gggagccugu accgacucca aagugaaucg gauuagauuc      420

aaggaucacg acuuugcugc caucgcggau uucgacaugg uccgcaacgc cguggaugcu      480

gccaaagcuc ucggcgugga cgccagaguc gggaaucugu uuucugcgga ccuguucuau      540

agccccgaug gagaaauguu ugacguuaug gagaaguacg gcauucucgg cguggagaug      600

gaagccgcug ggaucuaugg aguggccgcu gaguucggcg ccaaggcccu gacaauuugc      660

accgucuccg aucauauccg gacgcacgaa cagaccacag cugcggagcg ccaaaccaca      720

uuuaacgaca ugaucaaaau ugcccuugag ucugugcugc ucggggauaa ggaauga         777


<210>  6672
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__ABE10555

<400>  6672
auggaucuag gaggagcagu aacaccacca uuaauaugcc auaaaaaaga caaaaugaug       60

gcuacacccc auauaaaugc agaaauggga gacuucgccg auguaguacu aaugccagga      120

gacccacuaa gagcaaaaua cauagcagaa acauucuuag aagacgcaag agaaguaaau      180

aacguaagag gaaugcuagg auuuacagga acauauaaag gaagaaaaau aucaguaaug      240

ggacauggaa ugggaauacc aucaugcuca auauauacaa aagaauugau aacagacuuu      300

ggaguaaaaa aaauaauaag aguaggaagu ugcggagcag ugcuaccgca cguaaaauua      360

agagauguag uaauaggaau gggagcaugu acagauagca aaguaaauag aauaagauuu      420

aaagaucacg auuucgcagc aauagcagau uuugauaugg uaagaaaugc aguagacgcu      480

gcaaaagcau uaggaguaga cgcaagagua ggaaaucuau uuagcgcaga cuuauucuau      540

aguccagacg gagaaauguu ugacguaaug gaaaaauacg gaauauuagg uguagaaaug      600

gaagcagcag gaauauaugg uguagcagca gaauuuggag caaaagcacu aacaauaugu      660

acaguaagcg aucacauaag aacacacgaa caaacaacag cagcagaaag gcaaacaaca      720

uuuaaugaca ugauaaaaau agcauuagaa aguguacuau uaggagauaa agaauaa         777


<210>  6673
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__W8ZSE4

<400>  6673

Met Asp Leu Gly Gly Ala Val Thr Pro Pro Leu Ile Cys His Lys Lys 
1               5                   10                  15      


Asp Lys Thr Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe 
            20                  25                  30          


Ala Asp Val Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile 
        35                  40                  45              


Ala Glu Thr Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly 
    50                  55                  60                  


Met Leu Gly Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met 
65                  70                  75                  80  


Gly His Gly Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu 
                85                  90                  95      


Ile Thr Asp Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly 
            100                 105                 110         


Ala Val Leu Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly 
        115                 120                 125             


Ala Cys Thr Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp 
    130                 135                 140                 


Phe Ala Ala Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala 
145                 150                 155                 160 


Ala Lys Ala Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala 
                165                 170                 175     


Asp Leu Phe Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys 
            180                 185                 190         


Tyr Gly Ile Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val 
        195                 200                 205             


Ala Ala Glu Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp 
    210                 215                 220                 


His Ile Arg Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr 
225                 230                 235                 240 


Phe Asn Asp Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp 
                245                 250                 255     


Lys Glu 
        


<210>  6674
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6674
auggauuugg gcggagcagu gacuccgccu uuaauauguc acaaaaagga uaaaacgaug       60

gcuacuccac acauuaaugc agaaaugggc gauuuugcug acguaguuuu gaugccaggc      120

gacccgcugc gugcgaagua uauugcugaa acuuuccuug aagaugcccg ugaagugaac      180

aacguucgcg guaugcuggg cuucacuggu acuuacaaag gccgcaaaau uuccguaaug      240

ggccacggua uggguauccc guccugcucc aucuacacca aagaacugau cacugauuuc      300

ggcgugaaga aaauuauccg cguggguucc uguggcgcug uucugccgca cguaaaacug      360

cgcgacgucg uuaucgguau gggugccugc accgauucca aaguuaaccg cauccguuuu      420

aaagaccaug acuuugccgc uaucgcugac uucgacaugg ugcguaacgc gguagacgcg      480

gcaaaagcac ugggcguuga ugcucgcguu gguaaccugu ucuccgcuga ccuguucuac      540

ucuccggacg gcgaaauguu cgacgugaug gaaaaauacg gcauccucgg cguggaaaug      600

gaagcggcgg guaucuacgg cgucgcugca gaauuuggcg cgaaagcccu gaccaucugc      660

accgugucug accacauccg cacucacgag cagaccacug ccgcugagcg ucagaccacc      720

uucaacgaca ugaucaaaau cgcgcuggaa uccguucugc ugggcgauaa agaguaa         777


<210>  6675
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6675
auggaccugg gcggggccgu gaccccgccc cucaucugcc acaagaagga caagaccaug       60

gccacgcccc acaucaacgc ggagaugggc gacuucgccg acgucgugcu gaugcccggg      120

gacccccugc gcgccaagua caucgccgag accuuccucg aggacgcccg ggaggugaac      180

aacguccgcg gcaugcuggg guucaccggc accuacaagg gccggaagau cagcgugaug      240

gggcacggca uggggauccc guccugcagc aucuacacga aggagcugau caccgacuuc      300

ggcgugaaga agaucauccg cgucgggucc ugcggcgcgg ugcuccccca cgugaagcug      360

cgggacgucg ugaucggcau gggggccugc accgacagca aggugaaccg cauccgguuc      420

aaggaccacg acuucgccgc caucgcggac uucgacaugg uccgcaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgcgcggguc gggaaccucu ucuccgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg gguggagaug      600

gaggccgccg gcaucuacgg ggucgccgcg gaguucggcg ccaaggcccu caccaucugc      660

acgguguccg accacauccg cacccacgag cagaccaccg ccgccgagcg gcagacgacc      720

uucaacgaca ugaucaagau cgcgcuggag agcgugcugc ucggggacaa ggaguga         777


<210>  6676
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6676
auggaccucg gcggcgccgu cacccccccc cucaucugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acgucguccu caugcccggc      120

gacccccucc gcgccaagua caucgccgag accuuccucg aggacgcccg cgaggucaac      180

aacguccgcg gcaugcucgg cuucaccggc accuacaagg gccgcaagau cuccgucaug      240

ggccacggca ugggcauccc cuccugcucc aucuacacca aggagcucau caccgacuuc      300

ggcgucaaga agaucauccg cgucggcucc ugcggcgccg uccuccccca cgucaagcuc      360

cgcgacgucg ucaucggcau gggcgccugc accgacucca aggucaaccg cauccgcuuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg uccgcaacgc cgucgacgcc      480

gccaaggccc ucggcgucga cgcccgcguc ggcaaccucu ucuccgccga ccucuucuac      540

ucccccgacg gcgagauguu cgacgucaug gagaaguacg gcauccucgg cgucgagaug      600

gaggccgccg gcaucuacgg cgucgccgcc gaguucggcg ccaaggcccu caccaucugc      660

accgucuccg accacauccg cacccacgag cagaccaccg ccgccgagcg ccagaccacc      720

uucaacgaca ugaucaagau cgcccucgag uccguccucc ucggcgacaa ggaguga         777


<210>  6677
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6677
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaccaug       60

gcuacuccac auauuaacgc agagauggga gacuucgccg augucguucu uaugccgggu      120

gacccccuga gagcgaaaua cauagcugaa acguuuuugg aggaugccag ggaagugaau      180

aacguacggg gcauguuagg guucaccgga acauauaagg gccgcaaaau cagcgugaug      240

ggucacggga ugggcauucc uuccuguucu aucuacacua aggagcugau uaccgacuuu      300

ggagucaaga aaaucauacg agugggcuca ugcggggcag uucuaccaca ugugaagcuc      360

cgugaugucg ugaucggaau gggugccugu acagacagua aaguaaauag aauuagguuc      420

aaggaucacg acuuugcugc aaucgccgau uucgacaugg uucggaacgc uguggaugcc      480

gcgaaagcac ugggcgucga cgcccgcgug gggaaucuuu uuagcgcuga ccuguucuau      540

ucccccgaug gagaaauguu ugacgugaug gagaaguacg gcauuuuggg ugucgagaug      600

gaagccgcag ggaucuaugg aguugcugcc gaguucggcg cgaaggcccu caccauaugc      660

acugugucug aucauauuag aacacacgaa cagaccacgg cagcugagag gcaaacuacc      720

uuuaacgaca ugaucaaaau ugcccuggag ucgguacugc ucggcgauaa ggaauga         777


<210>  6678
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6678
auggaccugg gcggcgccgu gacccccccc cugaucugcc acaagaagga caagaccaug       60

gccacccccc acaucaacgc cgagaugggc gacuucgccg acguggugcu gaugcccggc      120

gacccccuga gagccaagua caucgccgag accuuccugg aggacgccag agaggugaac      180

aacgugagag gcaugcuggg cuucaccggc accuacaagg gcagaaagau cagcgugaug      240

ggccacggca ugggcauccc cagcugcagc aucuacacca aggagcugau caccgacuuc      300

ggcgugaaga agaucaucag agugggcagc ugcggcgccg ugcugcccca cgugaagcug      360

agagacgugg ugaucggcau gggcgccugc accgacagca aggugaacag aaucagauuc      420

aaggaccacg acuucgccgc caucgccgac uucgacaugg ugagaaacgc cguggacgcc      480

gccaaggccc ugggcgugga cgccagagug ggcaaccugu ucagcgccga ccuguucuac      540

agccccgacg gcgagauguu cgacgugaug gagaaguacg gcauccuggg cguggagaug      600

gaggccgccg gcaucuacgg cguggccgcc gaguucggcg ccaaggcccu gaccaucugc      660

accgugagcg accacaucag aacccacgag cagaccaccg ccgccgagag acagaccacc      720

uucaacgaca ugaucaagau cgcccuggag agcgugcugc ugggcgacaa ggaguga         777


<210>  6679
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6679
auggaccugg gcggggccgu gacacccccu cucaucugcc acaagaaaga uaagaccaug       60

gcuacgccgc auauuaacgc cgagauggga gacuucgcgg augucguucu gaugcccggc      120

gacccucuua gagcuaaaua caucgccgaa accuuucugg aggaugcccg ggaagugaau      180

aacgugcgcg ggaugcucgg auucacaggc accuauaagg ggagaaaaau uagcgucaug      240

ggacacggca ugggcauccc cuccuguucu auuuacacaa aggagcugau caccgacuuu      300

ggggugaaga aaaucauucg gguuggaagc ugcggcgcug ugcuuccuca ugucaagcug      360

cgcgaugugg uuaucgggau gggagccugu acagacucca aagugaaucg gauuagauuc      420

aaggaucacg acuuugcugc caucgcggau uucgacaugg uccgcaacgc cguggaugcu      480

gccaaagcuc ucggcgugga cgccagaguc gggaaucugu uuucugcgga ccuguucuau      540

agccccgaug gagaaauguu ugacguuaug gagaaguacg gcauucucgg cguggagaug      600

gaagccgcug ggaucuaugg aguggccgcu gaguucggcg ccaaggcccu gaccauuugc      660

acggucuccg aucauauccg gacccacgaa cagacaaccg cugcggagcg ccaaacaacc      720

uuuaacgaca ugaucaaaau ugcccuugag ucugugcugc ucggggauaa ggaauga         777


<210>  6680
<211>  777
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__CDN85331

<400>  6680
auggauuuag gaggagcagu aacaccacca cuaauaugcc auaaaaaaga uaaaacaaug       60

gcgacaccac auaucaaugc agagaugggu gacuuugcag auguaguacu aaugccagga      120

gauccacuaa gggcaaaaua uauagcagaa acauuucuag aagacgcaag agaaguaaau      180

aauguaagag gaauguuagg auuuacagga acauauaaag guagaaaaau aucaguaaug      240

ggacauggaa ugggaauacc aaguugcagu auauauacaa aagaauuaau aacagacuuu      300

ggaguaaaaa aaauaauaag aguaggaagu ugcggagcag uauuaccaca cguaaaauua      360

agagauguag uaauaggaau gggggcgugu acagauagca aagucaacag aauaagauuu      420

aaagaucacg auuucgcagc aauagcagac uucgauaugg uaagaaaugc aguagacgca      480

gcaaaagcau uaggaguaga cgcaagagua ggcaaucuau uuagcgcaga ccuauucuau      540

ucaccagacg gagaaauguu cgauguaaug gaaaaauacg gaauauuagg aguagaaaug      600

gaagcagcag gaauauaugg aguagcagca gaauuuggag caaaagcacu aacaauaugu      660

acaguuagcg aucauauuag aacacacgaa caaacaacag cagcagaaag acaaacaaca      720

uucaaugaca ugauaaagau agcacuagaa aguguauuau uaggagauaa agaauaa         777


<210>  6681
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__X5FDR9

<400>  6681

Met Lys Lys Asp Met Asp Ile Asn Ile Asp Ala Leu Leu Arg Asp Thr 
1               5                   10                  15      


Phe Leu Thr Val Val Glu Leu Arg Gln Gly Thr Thr Val Arg His Gly 
            20                  25                  30          


Ile Glu Leu Tyr Arg His Cys Gln Arg Gln Val Glu Leu Val Arg Glu 
        35                  40                  45              


Arg Leu Lys Asp Ala Gly Phe Ser Arg Glu Asn Val Glu His Ile Thr 
    50                  55                  60                  


Tyr Ala Gln Cys Ala Leu Leu Asp Glu Thr Val Leu Ser Arg Ser Gly 
65                  70                  75                  80  


Met Asp Asp Gly Gln Ala Ile Trp Met Lys Asn Pro Leu Gln Ser His 
                85                  90                  95      


Phe Phe Asn Thr Leu Gln Ala Gly Glu Leu Leu Tyr Glu Arg Met Lys 
            100                 105                 110         


Gln Val Leu Gln Glu Pro Ala Pro Ala Gln Ala Val Leu Thr Cys Phe 
        115                 120                 125             


His Arg Val Leu Leu Leu Gly Phe Arg Gly Arg Tyr Gln Asp Pro Ala 
    130                 135                 140                 


Ala Pro Glu Arg Asp Gln Leu Ile Ser Thr Leu Asn Gly Gln Val Ala 
145                 150                 155                 160 


Pro Phe Gly Val Leu Pro Glu Thr Ala Val Leu Asn Val Pro Leu Ser 
                165                 170                 175     


Thr Arg Gln His Pro Leu Leu His Ser Pro Phe Phe Trp Leu Val Thr 
            180                 185                 190         


Leu Ala Leu Leu Leu Ala Gly Val Trp Trp Gly Leu His His Trp Leu 
        195                 200                 205             


Asn Val Leu Val Asp Glu Leu Leu Pro Gln Ser Leu Arg 
    210                 215                 220     


<210>  6682
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6682
augaaaaaag auauggauau caauaucgau gcgcugcugc gcgacacguu ucugacggug       60

guggaacugc gucagggaac caccgugcgu cacgguaucg agcuguaucg ccacugucag      120

cggcaggugg aacugguccg cgaacgucug aaagaugccg gauucagucg ggagaacgug      180

gagcacauaa cuuacgcgca gugcgcccug cuggacgaaa cggugcucag ccguaguggc      240

auggacgacg gucaggccau cuggaugaaa aacccacucc agucgcauuu cuucaacacc      300

cugcaggccg gugagcugcu guacgagcgg augaagcagg ugcuacagga acccgccccc      360

gcgcaggccg ugcugaccug cuuucaccgu guccugcugc ugggauuucg cgggcguuau      420

caggauccgg cagccccgga gcgcgaccag cuuauuucga cgcucaacgg gcaggucgcg      480

ccauuuggug ugcugccgga aacggcggua cugaacgugc cguuauccac ccgucagcac      540

ccuuugcugc auucgccauu uuucuggcug guaacacugg cgcugcuacu ggcgggcguc      600

uggugggggc uacaccacug gcugaaugua cugguggaug aacugcugcc gcaaagccug      660

cguuaa                                                                 666


<210>  6683
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6683
augaagaagg acauggacau caacaucgac gcccugcucc gcgacaccuu ccugaccgug       60

gucgagcugc ggcagggcac gaccgugcgc cacgggaucg agcucuaccg gcacugccag      120

cgccaggugg agcugguccg ggagcgccug aaggacgccg gcuucagccg ggagaacgug      180

gagcacauca ccuacgcgca gugcgcccuc cuggacgaga ccgugcuguc ccgcagcggg      240

auggacgacg gccaggccau cuggaugaag aacccccucc agucccacuu cuucaacacg      300

cugcaggccg gggagcugcu cuacgagcgg augaagcagg uccugcagga gccggccccc      360

gcgcaggccg ugcugaccug cuuccaccgc gugcuccugc ugggcuuccg gggccgcuac      420

caggaccccg ccgcccccga gcgggaccag cucaucagca cccugaacgg gcaggucgcg      480

ccguucggcg ugcugcccga gaccgccgug cucaacgucc cccuguccac gcgccagcac      540

ccccugcucc acagcccguu cuucuggcug gugacccugg cccuccugcu ggccggggug      600

ugguggggcc uccaccacug gcugaacguc cugguggacg agcuccugcc ccagucccug      660

cgguga                                                                 666


<210>  6684
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6684
augaagaagg acauggacau caacaucgac gcccuccucc gcgacaccuu ccucaccguc       60

gucgagcucc gccagggcac caccguccgc cacggcaucg agcucuaccg ccacugccag      120

cgccaggucg agcucguccg cgagcgccuc aaggacgccg gcuucucccg cgagaacguc      180

gagcacauca ccuacgccca gugcgcccuc cucgacgaga ccguccucuc ccgcuccggc      240

auggacgacg gccaggccau cuggaugaag aacccccucc agucccacuu cuucaacacc      300

cuccaggccg gcgagcuccu cuacgagcgc augaagcagg uccuccagga gcccgccccc      360

gcccaggccg uccucaccug cuuccaccgc guccuccucc ucggcuuccg cggccgcuac      420

caggaccccg ccgcccccga gcgcgaccag cucaucucca cccucaacgg ccaggucgcc      480

cccuucggcg uccuccccga gaccgccguc cucaacgucc cccucuccac ccgccagcac      540

ccccuccucc acucccccuu cuucuggcuc gucacccucg cccuccuccu cgccggcguc      600

ugguggggcc uccaccacug gcucaacguc cucgucgacg agcuccuccc ccagucccuc      660

cgcuga                                                                 666


<210>  6685
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6685
augaagaagg acauggauau caacauugac gcccugcuca gagauaccuu ccuuacagug       60

gucgagcuga ggcagggcac uacgguucgg cacgggauag aauuguaccg ccauugccaa      120

cgacaggugg aguuaguacg ugaaagacug aaggacgcug gauuuagcag ggagaaugug      180

gaacacauca ccuaugcaca gugugcccua cucgaugaga caguccuguc ccggucuggu      240

auggacgaug gccaggcgau uuggaugaaa aacccccuuc aaucacauuu cuuuaauacu      300

cugcaggcug gggaguugcu cuacgaacgc augaaacagg ugcugcagga gccugcccca      360

gcacaagccg uucugaccug cuuccacaga gugcucuuac ugggauuuag gggccgguau      420

caggacccgg cugcacccga acgcgaucag cuuaucagua cauugaacgg ucaggucgcc      480

ccuuucgggg ugcugccaga gaccgcugua cuaaauguuc cccucagcac ucgacaacau      540

ccucugcuuc acuccccauu uuucuggcug gugacauugg cccuccuguu agcgggaguc      600

ugguggggcc ugcaccauug gcucaacgug cuuguggacg agcuguugcc ccagucucua      660

agauga                                                                 666


<210>  6686
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6686
augaagaagg acauggacau caacaucgac gcccugcuga gagacaccuu ccugaccgug       60

guggagcuga gacagggcac caccgugaga cacggcaucg agcuguacag acacugccag      120

agacaggugg agcuggugag agagagacug aaggacgccg gcuucagcag agagaacgug      180

gagcacauca ccuacgccca gugcgcccug cuggacgaga ccgugcugag cagaagcggc      240

auggacgacg gccaggccau cuggaugaag aacccccugc agagccacuu cuucaacacc      300

cugcaggccg gcgagcugcu guacgagaga augaagcagg ugcugcagga gcccgccccc      360

gcccaggccg ugcugaccug cuuccacaga gugcugcugc ugggcuucag aggcagauac      420

caggaccccg ccgcccccga gagagaccag cugaucagca cccugaacgg ccagguggcc      480

cccuucggcg ugcugcccga gaccgccgug cugaacgugc cccugagcac cagacagcac      540

ccccugcugc acagccccuu cuucuggcug gugacccugg cccugcugcu ggccggcgug      600

ugguggggcc ugcaccacug gcugaacgug cugguggacg agcugcugcc ccagagccug      660

agauga                                                                 666


<210>  6687
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6687
augaagaaag acauggauau caacauugac gcccugcuca gagauaccuu ccugacagug       60

gucgagcuuc ggcagggcac gaccguucgc cacgggaucg aacuguacag acauugccaa      120

cgccaggugg agcucgugcg ggaaagacug aaggacgcug gauuuagccg ggagaauguc      180

gaacacauua cauaugccca gugugcgcuu cuggaugaga ccgugcucuc ccgcucuggc      240

auggacgaug ggcaggcuau cuggaugaaa aacccccugc aaagccauuu cuuuaauaca      300

cugcaggccg gagagcuccu guacgaaaga augaagcagg uucuucagga gccugccccg      360

gcucaagccg ugcugaccug cuuccaccgg guccuccugc uuggcuuucg cgggagauau      420

caggaccccg cugccccuga acgggaucag cugauuucca cacucaacgg acagguggcg      480

cccuucggcg uucugccuga gaccgccgug cugaaugucc cccucucuac gcgccaacau      540

ccucugcuuc acagcccguu uuucuggcug gugacccucg cucugcuucu ggccggcgug      600

uggugggggc uccaccauug gcugaacguc cugguugacg agcuccugcc ccagucccuu      660

agauga                                                                 666


<210>  6688
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Purine_Nucleoside_Phosphorylase_deoD__Escherichia_coli__AHW84482

<400>  6688
augaaaaaag acauggauau aaacauagac gcauuacuaa gagacacauu cuuaacagua       60

guagaauuaa gacaaggaac aacaguuaga cacggaauag aacuauacag acacugccaa      120

agacaaguag aacuaguaag agaaagauua aaagacgcag gauucagcag agaaaaugua      180

gaacacauaa cauacgcaca augcgcacuc cuagaugaaa caguccuauc uagaucagga      240

auggacgacg gacaagcaau auggaugaaa aacccacuac aaucacacuu cuucaacaca      300

cuacaagcag gagaauuacu auacgaaaga augaaacaag uacuacaaga accagcacca      360

gcccaagcag uacuaacaug cuuucacaga guacuacuac uaggcuuuag aggaagauac      420

caagacccag cugcaccaga aagagaucaa cuaauuucaa cauuaaacgg acaaguagca      480

ccauucggag uacuaccaga aacagcaguc uuaaauguac cacuaucaac aagacaacac      540

ccacuauuac acucaccauu cuucugguua guaacacuag cccuacuacu agcaggagua      600

ugguggggac uacaccacug gcuaaacgua cuaguagacg aacuacuacc acaaucacua      660

agauaa                                                                 666


<210>  6689
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPP5

<400>  6689

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Asn Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Lys Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Arg Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Glu 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Gln Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6690
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6690
auggcuucgu accccugcca ucaacacgcg ucggcguucg accaggcugc gcguucucgc       60

ggccauaaca accgacguac ggcguugcgc ccucgccggc agcaaaaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug uguuacccgg ccgcgcgaua ccguaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacgag      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

caaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca cccccggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacua a              1131


<210>  6691
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6691
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacaaca accgccggac cgcccugcgc ccgcggcgcc agcagaaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggcu cccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcgcgug cucggggcca gcgagaccau cgccaacauc      300

uacaccacgc agcaccggcu ggaccagggc gagaucuccg ccggcgacgc ggccgugguc      360

augaccagcg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcuccagc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccgcc accccaucgc cgcccugcuc ugcuaccccg ccgcccggua ccgcaugggg      540

uccaugaccc cgcaggccgu ccuggccuuc guggcgcuga ucccgcccac ccuccccggc      600

accaacaucg ugcugggcgc ccugcccgag gaccggcaca ucgaccgccu cgccaagcgg      660

cagcgccccg gggagcggcu ggaccuggcc augcucgccg cgauccgccg ggucuacgag      720

cugcuggcca acacggugcg cuaccuccag ggcgggggca gcuggcgcga ggacuggggc      780

cagcuguccg ggaccgccgu gccgccccag ggcgccgagc cccagagcaa cgcggggccc      840

cagccccaca ucggcgacac ccuguucacc cucuuccggg cccccgagcu gcuggccccg      900

aacggggacc ucuacaacgu cuucgccugg gcccuggacg ugcuggcgaa gcgccuccgg      960

cccaugcacg uguucauccu ggacuacgac cagucccccg ccggcugccg cgacgcccug     1020

cuccagcuga cgagcggcau gguccagacc cacgugacca cccccggguc caucccgacg     1080

aucugcgacc uggcccggac cuucgcccgc gagaugggcg aggcgaacug a              1131


<210>  6692
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6692
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacaaca accgccgcac cgcccuccgc ccccgccgcc agcagaaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccgcaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacgag      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cagccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6693
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6693
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacaaca aucggcgcac cgcucugcga ccucguagac agcagaaggc cacagaggug      120

aggcucgaac agaaaaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaagacga ccacaacuca auuguuaguu gcacugggcu cacgcgacga uauuguguac      240

guacccgagc cuaugaccua uuggagagug cuaggggcca gugaaacaau agcuaacauc      300

uacaccacuc agcacaggcu cgaccaggga gagauuagcg caggcgaugc cgcugucgug      360

augacauccg cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaagc cgggucuucg cacgccccuc cacccgcacu uacucugauc      480

uuugaucggc acccuauagc ugccuugcuc uguuacccag cggcccgcua ucgaaugggc      540

ucaaugaccc cgcaagcagu ccuggcuuuc guggcccuga uucccccuac acucccaggc      600

acuaauaucg uauuaggagc ucugcccgag gacagacaua ucgauaggcu ugccaaacgg      660

cagcguccug gugagcgcuu ggaccuggca augcuagccg cuauuagaag gguuuacgaa      720

cuccuggcga acaccgugcg guaccuucag ggcgggggaa gcuggcgaga ggauuggggc      780

cagcugagug guacagcagu cccaccccaa ggggccgaac cgcaguccaa ugcuggaccu      840

cagccccaca ucggcgacac cuuguuuacu cucuuccgcg ccccagagcu guuagcaccu      900

aacggcgauc uguauaaugu guuugccugg gcucucgacg ugcuugccaa gagacugagg      960

cccaugcaug ucuucauauu ggacuacgau caaucuccag cagggugccg ggacgcgcua     1020

cugcagcuca cgagcggaau gguucagaca cacgugacca cucccgguuc cauuccuaca     1080

aucugugauc uggcucgcac cuuugccaga gagaugggcg aagcaaacug a              1131


<210>  6694
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6694
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacaaca acagaagaac cgcccugaga cccagaagac agcagaaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua cagaaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacgag      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

cagccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6695
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6695
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacaaca aucgcagaac cgcccugcgg ccucgcagac agcagaaggc cacagaggug      120

cggcucgaac agaaaaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaagacca caaccacaca acugcucguu gcucugggga gcagagacga uauuguguac      240

gugccugagc ccaugaccua uuggcggguc cuuggagccu ccgaaacaau cgcuaacauu      300

uacaccacgc agcaccgccu ggaccagggc gagaucucug ccggggaugc ggccgugguu      360

augaccagcg cucagauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcu      420

ccccauaucg gcggcgaagc gggguccucu cacgccccuc cgcccgcucu gacacugauc      480

uuugauagac acccuauugc cgcucuccug uguuaccccg ccgcccggua ucgcauggga      540

agcaugaccc cucaagcugu gcuugcguuc guugcccuga uucccccgac gcucccuggc      600

acaaauaucg ugcugggggc ccuucccgag gacagacaua ucgaucggcu ggccaaacgc      660

cagagaccug gagagcggcu cgaccuggcc augcuggcug ccauuagacg cgucuacgaa      720

cuccuggcga acaccgugcg guaccuucag ggcgggggau ccuggagaga ggauuggggc      780

cagcugagcg gcacagcugu gccuccccaa ggggccgaac cccagucuaa ugccggaccg      840

cagccccaca ucggcgacac ccucuuuacc cuguuccgcg cuccugagcu ucuggccccc      900

aacggggauc ucuauaaugu cuuugcuugg gcccuggacg uucuggcgaa gcggcucaga      960

ccuaugcaug uguucauucu ggacuacgau caaucccccg ccggaugccg cgacgcccuu     1020

cugcagcuca caagcggcau ggugcagacg cacgucacca caccgggguc uaucccuacc     1080

aucugugauc uggcucggac auuugcuaga gagaugggag aagccaacug a              1131


<210>  6696
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59251

<400>  6696
auggcaagcu auccuuguca ccaacaugca ucagcauucg aucaagcagc gagaucuaga       60

ggacacaaua acagaagaac agcguuaaga ccaaggagac aacaaaaagc aaccgaaguu      120

agacuagaac aaaaaaugcc aacacuacua agaguauaca uugacggacc ccauggaaug      180

ggaaaaacaa caacaacaca auuacuugua gcacuaggaa gucgagauga uauagucuau      240

guaccagaac caaugacaua uuggagaguu uuaggagcua gugaaacuau agcaaauaua      300

uauacaacac aacacagacu agaucaagga gaaaucagug caggagaugc ugcaguagua      360

augacaucag cacaaauaac aaugggaaug ccauaugcag ucacagaugc aguauuagca      420

ccacauauag guggugaagc aggcagcucu caugcaccac cacccgcauu aacauuaauu      480

uuugauagac auccaauagc agcauuacuu ugcuauccag cagcaagaua cagaaugggc      540

aguaugacac cacaagcagu auuagcauuu guagcacuaa uaccaccaac auuaccuggc      600

acaaauauag uuuuaggugc acuaccagaa gauagacaua uagaucgacu agcaaaacga      660

caaaggcccg gagaaagauu agauuuagca augcucgcag caaucagaag aguauaugaa      720

uuauuagcaa acaccguaag auacuuacaa ggaggaggau cauggagaga agauugggga      780

caacuaagug gaacagcagu acccccacaa ggugcugaac cacaaucaaa ugcaggaccg      840

caaccccaua uaggagauac acucuuuaca uuauuuagag cuccagaacu auuagcacca      900

aauggagauc uauauaaugu auuugcaugg gcacuagaug uguuagcaaa aagauuaagg      960

cccaugcaug uauuuauacu agauuacgau caaucaccug caggaugucg agaugcccuc     1020

uuacaacuaa caucaggaau gguacaaaca cauguaacaa cuccaggaag uauaccaaca     1080

auaugugauu uagcaagaac auuugccaga gaaaugggag aagcaaauua a              1131


<210>  6697
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPP6

<400>  6697

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val His Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Val 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Pro Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala His 
    370                 375     


<210>  6698
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6698
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

caccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcggua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc gugguccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gugagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cuacuugcca auacggugcg guaucugcag ugcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccuu gacgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggaaac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc caugucaccc ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcucacua a              1131


<210>  6699
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6699
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

caccucgagc agaagaugcc cacgcugcug cgggucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcuccuggug gcgcugggga gccgcgacga caucguguac      240

guccccgagc cgaugaccua cuggcgggug cucggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcgaggc cgggagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggc      540

agcaugaccc cgcaggccgu ccuggccuuc guggugcuca ucccgcccac ccugcccggc      600

accaacaucg uccugggggc gcuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gcgagcggcu ggaccucgcc augcuggccg ccauccgccg gguguacggg      720

cugcucgcga acacggugcg cuaccugcag ugcggcggcu ccuggcggga ggacuggggg      780

cagcugagcg gcaccgcccu cacgccccag ggggccgagc cccaguccaa cgccggcccg      840

cgcccccaca ucggggagac ccuguucacc cuguuccgcg cgcccgagcu ccuggccccc      900

aacggcgacc uguacaacgu cuucgccugg gcccucgacg ugcuggccaa gcggcugcgc      960

ccgaugcacg uguucauccu cgacuacgac cagagccccg cgggcugccg ggacgcccug     1020

cugcagcuca ccuccgggau gguccagacc cacgugaccc cgcccggcag cauccccacg     1080

aucugcgacc uggcccgcac cuucgcccgg gagauggggg aggcccacug a              1131


<210>  6700
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6700
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

caccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucguccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ugcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgcccu caccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgagac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucaccc cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggcccacug a              1131


<210>  6701
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6701
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc aacucuucug agggucuaua ucgauggacc gcacgguaug      180

ggcaaaacga ccacaacuca auuguuaguu gcacugggga gucgggacga uauuguguac      240

guacccgaac cuaugaccua uuggcgcgug cuaggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcauagacu cgaccagggc gaaauuuccg ccggugaugc cgcugucgug      360

augacaucug cccagaucac cauggggaug ccauaugcgg uuacggacgc agugcuggca      420

ccccacauug gaggcgaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc auccuauagc ugccuugcuc ugcuacccag cggcccggua ucugaugggg      540

agcaugaccc cgcaagcagu ccuggcuuuc gugguacuca uucccccuac auuaccagga      600

acuaacaucg uucugggugc ccuucccgag gaccgccaca ucgaucgauu ggcuaagaga      660

cagaggccug gcgaacggcu ggaccuagcc augcucgcag ccauucgucg cguguacggg      720

cugcuugcua auaccgucag auaccugcag uguggaggca guuggaggga ggauuggggu      780

caguuguccg ggacagcgcu caccccacaa ggagcagaac cccagucuaa cgccggcccg      840

cggccucaua ucggcgagac gcuguuuacu uuauuccgag cucccgagcu gcucgcccca      900

aauggggacc uuuauaacgu guuugcaugg gcccuggaug uguuggcuaa acgccuaaga      960

ccuaugcacg ucuucauacu ggacuacgac cagagccccg ccggaugcag ggaugcacuc     1020

cugcaacuua cauccgguau gguucagacc cacgugacuc cacccggcuc aauuccuaca     1080

aucugugacc uggcgcggac cuuugcucgc gaaauggggg aggcccauug a              1131


<210>  6702
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6702
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

caccuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggugcuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ugcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgcccu gaccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgagac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugaccc cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggcccacug a              1131


<210>  6703
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6703
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc gacgcugcuu cgggucuaua ucgauggacc ccacggcaug      180

gggaaaacca caaccacaca acugcucguu gcucugggau cccgcgacga uauuguguac      240

gugccugaac ccaugaccua uuggagaguc cuuggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaucggcu ggaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaugggcaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccacaucg gcggggaggc cggaucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc auccuauugc cgcucuccug ugcuaccccg ccgccagaua ucuuaugggc      540

uccaugaccc cucaagcugu gcuggcguuc guugugcuca uucccccgac gcugccuggg      600

acaaacaucg uccuuggagc ccugcccgag gaccggcaca ucgaucgccu cgcuaagaga      660

cagcggccug gcgaacgccu ggaccuggcc augcucgccg cuauuagacg gguguacggg      720

cugcuugcca auaccgugag auaccugcag uguggaggca gcuggcgcga ggauuggggc      780

cagcucucug ggacagcgcu gacaccccaa ggagcugaac cccaguccaa cgccggcccu      840

cggccgcaua ucggggagac ccuuuuuacc cuguucagag cccccgagcu ccuggcuccu      900

aauggagacc uguauaacgu cuuugccugg gcucucgaug uucuggccaa acgccuucgg      960

cccaugcacg uguucauucu ggacuacgac cagagcccug cgggcugcag agaugcccuc     1020

cugcaacuua cgucugggau ggugcagacc cacgucacac ccccgggauc caucccuacc     1080

aucugugacc uggcucgcac auuugcccgg gaaaugggcg aggcucauug a              1131


<210>  6704
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59252

<400>  6704
auggcaucau auccaggaca ucaacaugca agcgcauuug aucaagcagc aagaucaaga       60

ggccacagca auagaagaac cgcacuuaga ccaagacgac aacaagaagc aacggaagua      120

cauuuagaac aaaaaaugcc aacacuuuua cgaguauaua uugauggacc acauggaaug      180

ggaaaaacua caacaacaca acuauuagua gcauuaggca guagagauga uauaguuuau      240

guaccagaac caaugacaua uuggagaguu uuaggagcau cagaaacaau agcaaauaua      300

uauaccacac aacauaggcu ugaccaagga gaaauaagug cuggcgaugc cgcaguaguc      360

augacuuccg cacaaauaac uauggguaug ccauaugcag uaacagaugc cguacuagca      420

ccacacauug guggagaagc cgguucaagu caugcaccuc caccagcauu aacacugaua      480

uuugauagac auccaauagc ugcacuauua uguuauccag cagcuagaua uuuaauggga      540

ucaaugacac cucaagcagu acuagcauuc gucguuuuaa uuccaccaac auuaccagga      600

acuaauauag uacuuggagc auuaccagaa gauagacaua uagacaggcu ugcaaaaaga      660

caacgaccag gagaaagauu agauuuagca auguuagcag caauaagaag aguuuaugga      720

uuauuagcaa auacaguaag auauuuacaa uguggaggau cauggagaga agauugggga      780

caacucucag gaacagcuuu aaccccacaa ggagcugaac cacaaucaaa ugcaggacca      840

agaccacaua uaggagaaac auuauuuaca cucuucagag caccagaauu acuagcacca      900

aauggagauu uauauaaugu auuugccugg gcacuagaug uauuagcaaa aagauuaaga      960

ccuaugcaug uauuuauauu agauuaugac caaucaccag caggaugcag agaugcuuua     1020

uuacaacuaa caagugguau gguacaaaca cauguaacac caccuggaag uauaccaaca     1080

auaugugacu uagcacgaac auucgcaaga gaaaugggag aggcacauua a              1131


<210>  6705
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPP7

<400>  6705

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Glu 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Pro 
    370                 375     


<210>  6706
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6706
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgcccggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cgugcuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug uguuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugccgggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacgag      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccuu gacgccccag ggugccgagc cccagagcaa cgcgggcccg      840

cgaccccaua ucggggaaac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcucccua a              1131


<210>  6707
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6707
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcccgagc agaagaugcc cacgcuccug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcugcucgug gcgcugggca gccgggacga caucguguac      240

gucccggagc ccaugaccua cuggcgcgug cugggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccggcu cgaccagggc gagaucagcg ccggcgacgc ggccgugguc      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgccccgc cgcccgcccu gacgcucauc      480

uucgaccgcc accccaucgc cgcgcugcug ugcuaccccg ccgcccggua ccucaugggg      540

agcaugacgc cccaggccgu ccuggccuuc guggcgcuga ucccgcccac ccuccccggc      600

accaacaucg ugcugggcgc ccugcccgag gaccgccaca ucgaccggcu cgccaagcgc      660

cagcggcccg gggagcgccu ggaccuggcc augcucgccg cgauccggcg cgucuacgag      720

cugcuggcca acaccgugcg guaccuccag ggcgggggcu ccuggcgcga ggacuggggc      780

cagcugagcg ggaccgcccu gacgccccag ggcgccgagc cgcaguccaa cgcggggccc      840

cgcccccaca ucggcgagac ccucuucacc cuguuccggg cccccgagcu gcucgccccg      900

aacggggacc uguacaacgu guucgccugg gcccuggacg uccucgcgaa gcgccugcgg      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugccg cgacgcccuc     1020

cugcagcuga ccuccggcau ggugcagacc cacgucacca cgcccgggag caucccgacc     1080

aucugcgacc ucgcccggac cuucgcccgc gagaugggcg aggcgcccug a              1131


<210>  6708
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6708
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccccgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacgag      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgcccu caccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgagac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggcccccug a              1131


<210>  6709
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6709
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggccagagc agaagaugcc gacucuccuu cgggucuaua ucgaugggcc ccauggaaug      180

gguaaaacga ccacaacuca acuguugguu gcauuaggca gucgcgacga uauuguguac      240

guaccugaac caaugaccua uuggagagug cugggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacaggcu agaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug cccuaugcgg uuacggacgc agugcucgcc      420

ccucauauug ggggagaggc uggcucguca cacgccccac ccccugcacu gacucuuauc      480

uuugaucggc acccaauagc ugcccuguug uguuacccgg cggcccgcua ucucaugggc      540

agcaugacac cccaagcagu ccuggcuuuc guggcccuga ucccuccaac ccuccccggg      600

acuaacauug uauuaggagc ucugccugag gaccgacaua ucgauagacu ugccaagagg      660

cagcggccag gugaacguuu ggaccuggca augcuagccg cuauucgcag aguuuacgag      720

cuccuggcga auaccgugag guaccuucag ggcgggggaa guuggcggga agauuggggc      780

cagcuguccg guacagcauu gacgccccaa ggggccgagc cgcagucuaa cgcuggaccu      840

cgaccccaca ucggcgagac ccucuuuacu cuguuccgcg ccccagaauu acuggcaccu      900

aauggcgacc ucuauaacgu cuuugccugg gcucuugaug ugcuggccaa aagauugagg      960

cccaugcaug uguucauacu agacuacgac cagagcccag cagggugccg ggaugcgcug     1020

cuccaacuga cauccggaau gguccagacc cacguuacua cacccgguuc aauuccuacc     1080

aucugugacc uugcucgcac guuugccaga gagaugggcg aagcaccaug a              1131


<210>  6710
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6710
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacccgagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacgag      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgcccu gaccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgagac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggcccccug a              1131


<210>  6711
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6711
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggccggagc agaagaugcc cacgcuccug cgcgucuaua ucgaugggcc ucauggaaug      180

ggcaaaacca caaccacaca acuucugguu gcucucgggu ccagagacga uauuguguac      240

gugcccgaac cuaugaccua uuggcggguc cugggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccgccu ugaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucagauuac aaugggaaug cccuaugccg ugaccgacgc uguccuggcc      420

ccucauaucg gcggcgaggc ggggucuagc cacgccccgc ccccugcucu cacacugauc      480

uuugauagac accccauugc cgcucugcuc uguuacccug ccgcccggua ucugauggga      540

uccaugacgc cccaagcugu gcuugcguuc guugcccuga ucccgccuac ccuccccggc      600

acaaacauug ugcugggggc ccuuccugag gaccgccaua ucgauagacu ggcuaagcgg      660

cagcgccccg gagaaagacu cgaccuggcc augcuggcug ccauucggag agucuacgag      720

cuccuggcga auaccgugcg cuaccuucag ggcgggggaa gcuggcggga agauuggggc      780

cagcugucug gcacagcucu cacaccccaa ggggccgagc cucaguccaa cgccggaccg      840

agaccccaca ucggcgagac ccuguuuacc cuuuuccgcg cuccugaacu gcucgccccc      900

aauggggacc uguauaacgu guuugcuugg gcccuggaug uccucgcgaa acggcugaga      960

ccuaugcaug uuuucauucu ugacuacgac cagagccccg ccggaugccg cgaugcucug     1020

cuccaacuga cgucuggcau ggugcagacc cacgugacaa ccccgggguc caucccuaca     1080

aucugugacc uugcccggac cuuugcuaga gagaugggag aagcccccug a              1131


<210>  6712
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59253

<400>  6712
auggcuucgu acccaugcca ucaacaugca agcgcauucg aucaagcagc aagaucaaga       60

ggacauagua aucgaagaac agcucuaaga ccaagaagac aacaagaagc uacagaagua      120

agaccagaac aaaaaaugcc uacauuacua agaguauaua uagauggacc ucauggaaug      180

ggaaaaacaa caacaacaca acuacuuguu gcauuaggau caagagauga uauaguuuac      240

guuccagaac cgaugacaua cuggagagua cuaggagcau cagaaacaau agcaaacauu      300

uauacaacac aacauagauu agaucaagga gaaauaucag caggagaugc ugcaguagua      360

augacaagug cacaaauaac aaugggaaug ccauaugcag uaacagaugc uguacuagcg      420

ccacacauag gaggugaagc agguucauca cacgcaccac caccagcacu uacauuaaua      480

uuugauagac auccaauagc agcauuauug ugcuauccug cagcuagaua ucuuauggga      540

ucaaugacac cacaagcagu uuuagccuuu guugcuuuaa uacccccaac auuaccugga      600

acaaauauag uacuuggagc auuaccagaa gauagacaca uagauagguu agcaaaaaga      660

caaagaccag gagaaagacu ugaucuagca auguuggcug caauaagaag aguauaugaa      720

uuauuagcca auacaguaag auacuuacaa ggaggagguu cuuggagaga agauugggga      780

caacuaagcg gaacagcucu uacaccucaa ggagcagaac cccaaucaaa ugccggacca      840

agaccucaua uaggagaaac acuauuuacu uuauuuagag caccagaacu ucuagcaccu      900

aacggagacu uauauaacgu cuuugcaugg gcacuagacg uauuagcaaa aagauuaaga      960

ccaaugcaug uauuuauucu agauuaugau caaucaccag caggauguag agaugcauua     1020

uuacaacuca cuucaggaau gguacaaaca cauguaacua ccccaggaag uauaccaaca     1080

auuugugacc uugcuagaac auuugcacga gaaaugggag aggcaccaua a              1131


<210>  6713
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPP8

<400>  6713

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Ala Thr Glu Val His Leu Glu Gln Lys Met Pro Thr Leu 
        35                  40                  45              


Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr 
    50                  55                  60                  


Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val 
65                  70                  75                  80  


Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr Ile 
                85                  90                  95      


Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser 
            100                 105                 110         


Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly 
        115                 120                 125             


Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly Gly 
    130                 135                 140                 


Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe 
145                 150                 155                 160 


Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr 
                165                 170                 175     


Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Val Leu 
            180                 185                 190         


Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro 
        195                 200                 205             


Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu 
    210                 215                 220                 


Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu 
225                 230                 235                 240 


Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg Glu 
                245                 250                 255     


Asp Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala Glu 
            260                 265                 270         


Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu Phe 
        275                 280                 285             


Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr 
    290                 295                 300                 


Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Pro 
305                 310                 315                 320 


Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg 
                325                 330                 335     


Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr 
            340                 345                 350         


Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala 
        355                 360                 365             


Arg Glu Met Gly Glu Ala His 
    370                 375 


<210>  6714
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6714
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagccac ggaaguccac      120

cuggagcaga aaaugcccac gcuacugcgg guuuauauag acgguccuca cgggaugggg      180

aaaaccacca ccacgcaacu gcugguggcc cuggguucgc gcgacgauau cgucuacgua      240

cccgagccga ugacuuacug gcgggugcug ggggcuuccg agacaaucgc gaacaucuac      300

accacacaac accgccucga ccagggugag auaucggccg gggacgcggc ggugguaaug      360

acaagcgccc agauaacaau gggcaugccu uaugccguga ccgacgccgu ucuggcuccu      420

cauaucgggg gggaggcugg gagcucacau gccccgcccc cggcccucac ccucaucuuc      480

gaccgccauc ccaucgccgc ccuccugugc uacccggccg cgcgguaccu uaugggcagc      540

augacccccc aggccgugcu ggcguucgug guccucaucc cgccgaccuu gcccggcaca      600

aacaucgugu ugggggcccu uccggaggac agacacaucg accgccuggc caaacgccag      660

cgccccggug agcggcuuga ccuggcuaug cuggccgcga uucgccgcgu uuacgggcua      720

cuugccaaua cggugcggua ucugcagugc ggcgggucgu ggcgggagga uuggggacag      780

cuuucgggga cggccuugac gccccagggu gccgagcccc agagcaacgc gggcccacga      840

ccccauaucg gggaaacguu auuuacccug uuucgggccc ccgaguugcu ggcccccaac      900

ggcgaccugu acaacguguu ugccugggcc uuggacgucu uggccaaacg ccuccguccc      960

augcacgucu uuauccugga uuacgaccaa ucgcccgccg gcugccggga cgcccugcug     1020

caacuuaccu ccgggauggu ccagacccau gucaccaccc caggcuccau accgacgauc     1080

ugcgaccugg cgcgcacguu ugcccgggag augggggagg cucacuaa                  1128


<210>  6715
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6715
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggccac cgaggugcac      120

cucgagcaga agaugcccac gcugcugcgg gucuacaucg acggccccca cgggaugggc      180

aagaccacca ccacgcagcu ccugguggcg cuggggagcc gcgacgacau cguguacguc      240

cccgagccga ugaccuacug gcgggugcuc ggcgccuccg agaccaucgc caacaucuac      300

accacgcagc accgccugga ccagggcgag aucagcgccg gggacgcggc cguggucaug      360

accuccgccc agaucaccau gggcaugccc uacgccguga ccgacgccgu gcuggcgccc      420

cacaucgggg gcgaggccgg gagcucccac gcgcccccgc ccgcccucac gcugaucuuc      480

gaccggcacc ccaucgccgc ccugcucugc uaccccgccg cccgcuaccu gaugggcagc      540

augaccccgc aggccguccu ggccuucgug gugcucaucc cgcccacccu gcccggcacc      600

aacaucgucc ugggggcgcu ccccgaggac cggcacaucg accgccuggc caagcggcag      660

cgccccggcg agcggcugga ccucgccaug cuggccgcca uccgccgggu guacgggcug      720

cucgcgaaca cggugcgcua ccugcagugc ggcggcuccu ggcgggagga cugggggcag      780

cugagcggca ccgcccucac gccccagggg gccgagcccc aguccaacgc cggcccgcgc      840

ccccacaucg gggagacccu guucacccug uuccgcgcgc ccgagcuccu ggcccccaac      900

ggcgaccugu acaacgucuu cgccugggcc cucgacgugc uggccaagcg gcugcgcccg      960

augcacgugu ucauccucga cuacgaccag agccccgcgg gcugccggga cgcccugcug     1020

cagcucaccu ccgggauggu ccagacccac gugaccacgc ccggcagcau ccccaccauc     1080

ugcgaccugg cccgcaccuu cgcccgggag augggggagg cccacuga                  1128


<210>  6716
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6716
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggccac cgagguccac      120

cucgagcaga agaugcccac ccuccuccgc gucuacaucg acggccccca cggcaugggc      180

aagaccacca ccacccagcu ccucgucgcc cucggcuccc gcgacgacau cgucuacguc      240

cccgagccca ugaccuacug gcgcguccuc ggcgccuccg agaccaucgc caacaucuac      300

accacccagc accgccucga ccagggcgag aucuccgccg gcgacgccgc cgucgucaug      360

accuccgccc agaucaccau gggcaugccc uacgccguca ccgacgccgu ccucgccccc      420

cacaucggcg gcgaggccgg cuccucccac gccccccccc ccgcccucac ccucaucuuc      480

gaccgccacc ccaucgccgc ccuccucugc uaccccgccg cccgcuaccu caugggcucc      540

augacccccc aggccguccu cgccuucguc guccucaucc cccccacccu ccccggcacc      600

aacaucgucc ucggcgcccu ccccgaggac cgccacaucg accgccucgc caagcgccag      660

cgccccggcg agcgccucga ccucgccaug cucgccgcca uccgccgcgu cuacggccuc      720

cucgccaaca ccguccgcua ccuccagugc ggcggcuccu ggcgcgagga cuggggccag      780

cucuccggca ccgcccucac cccccagggc gccgagcccc aguccaacgc cggcccccgc      840

ccccacaucg gcgagacccu cuucacccuc uuccgcgccc ccgagcuccu cgcccccaac      900

ggcgaccucu acaacgucuu cgccugggcc cucgacgucc ucgccaagcg ccuccgcccc      960

augcacgucu ucauccucga cuacgaccag ucccccgccg gcugccgcga cgcccuccuc     1020

cagcucaccu ccggcauggu ccagacccac gucaccaccc ccggcuccau ccccaccauc     1080

ugcgaccucg cccgcaccuu cgcccgcgag augggcgagg cccacuga                  1128


<210>  6717
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6717
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggccac agaggugcau      120

cucgaacaga agaugccaac ucuucugagg gucuauaucg auggaccgca cgguaugggc      180

aaaacgacca caacucaauu guuaguugca cuggggaguc gggacgauau uguguacgua      240

cccgagccua ugaccuauug gcgcgugcua ggagccagcg aaacaauagc uaauaucuac      300

accacucagc auagacucga ccagggcgag auuuccgccg gugaugccgc ugucgugaug      360

acaucugccc agaucaccau ggggaugcca uaugcgguua cggacgcagu gcuggcaccc      420

cacauuggag gcgaagcugg cucgucacac gccccuccac ccgcacuuac ucugaucuuu      480

gauaggcauc cuauagcugc cuugcucugc uacccagcgg cccgguaucu gauggggagc      540

augaccccgc aagcaguccu ggcuuucgug guacucauuc ccccuacauu accaggaacu      600

aacaucguuc ugggugcccu ucccgaggac cgccacaucg aucgauuggc uaagagacag      660

aggccuggcg agcggcugga ccuagccaug cucgcagcca uucgucgcgu guacgggcug      720

cuugcuaaua ccgucagaua ccugcagugu ggaggcaguu ggagggaaga uuggggucag      780

uuguccggga cagcgcucac cccacaagga gcagagcccc agucuaacgc cggcccgcgg      840

ccucauaucg gcgaaacgcu guuuacuuua uuccgagcuc ccgagcugcu cgccccaaau      900

ggggaccuuu auaacguguu ugcaugggcc cuggaugugu uggcuaaacg ccuaagaccu      960

augcacgucu ucauacugga cuacgaccag agccccgccg gaugcaggga ugcacuccug     1020

caacuuacau ccgguauggu ucagacccac gugacuacac caggcucaau ucccaccauc     1080

ugugaccugg cgcggacguu ugcucgcgag augggggaag cccauuga                  1128


<210>  6718
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6718
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggccac cgaggugcac      120

cuggagcaga agaugcccac ccugcugaga guguacaucg acggccccca cggcaugggc      180

aagaccacca ccacccagcu gcugguggcc cugggcagca gagacgacau cguguacgug      240

cccgagccca ugaccuacug gagagugcug ggcgccagcg agaccaucgc caacaucuac      300

accacccagc acagacugga ccagggcgag aucagcgccg gcgacgccgc cguggugaug      360

accagcgccc agaucaccau gggcaugccc uacgccguga ccgacgccgu gcuggccccc      420

cacaucggcg gcgaggccgg cagcagccac gccccccccc ccgcccugac ccugaucuuc      480

gacagacacc ccaucgccgc ccugcugugc uaccccgccg ccagauaccu gaugggcagc      540

augacccccc aggccgugcu ggccuucgug gugcugaucc cccccacccu gcccggcacc      600

aacaucgugc ugggcgcccu gcccgaggac agacacaucg acagacuggc caagagacag      660

agacccggcg agagacugga ccuggccaug cuggccgcca ucagaagagu guacggccug      720

cuggccaaca ccgugagaua ccugcagugc ggcggcagcu ggagagagga cuggggccag      780

cugagcggca ccgcccugac cccccagggc gccgagcccc agagcaacgc cggccccaga      840

ccccacaucg gcgagacccu guucacccug uucagagccc ccgagcugcu ggcccccaac      900

ggcgaccugu acaacguguu cgccugggcc cuggacgugc uggccaagag acugagaccc      960

augcacgugu ucauccugga cuacgaccag agccccgccg gcugcagaga cgcccugcug     1020

cagcugacca gcggcauggu gcagacccac gugaccaccc ccggcagcau ccccaccauc     1080

ugcgaccugg ccagaaccuu cgccagagag augggcgagg cccacuga                  1128


<210>  6719
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6719
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggccac agaggugcau      120

cucgaacaga agaugccgac gcugcuucgg gucuauaucg auggacccca cggcaugggg      180

aaaaccacaa ccacacaacu gcucguugcu cugggauccc gcgacgauau uguguacgug      240

ccugagccca ugaccuauug gagaguccuu ggcgccucug aaacaaucgc uaauauuuac      300

accacgcagc aucggcugga ccagggggag aucagcgccg gagaugcggc cgugguuaug      360

accuccgcuc agauuacaau gggcaugccu uaugccguga ccgacgcugu ccucgcgccc      420

cacaucggcg gggaagccgg aucuagccac gccccuccgc ccgcucugac acugaucuuu      480

gaucgccauc cuauugccgc ucuccugugc uaccccgccg ccagauaucu uaugggcucc      540

augaccccuc aagcugugcu ggcguucguu gugcucauuc ccccgacgcu gccugggaca      600

aacaucgucc uuggagcccu gcccgaggac cggcacaucg aucgccucgc uaagagacag      660

cggccuggcg agcgccugga ccuggccaug cucgccgcua uuagacgggu guacgggcug      720

cuugccaaua ccgugagaua ccugcagugu ggaggcagcu ggcgcgaaga uuggggccag      780

cucucuggga cagcgcugac accccaagga gcugagcccc aguccaacgc cggcccucgg      840

ccgcauaucg gggaaacccu uuuuacccug uucagagccc ccgagcuccu ggcuccuaau      900

ggagaccugu auaacgucuu ugccugggcu cucgauguuc uggccaaacg ccuucggccc      960

augcacgugu ucauucugga cuacgaccag agcccugcgg gcugcagaga ugcccuccug     1020

caacuuacgu cugggauggu gcagacccac gucacaaccc ccggauccau cccgacaauc     1080

ugugaccugg cucgcaccuu ugcccgggag augggcgaag cucauuga                  1128


<210>  6720
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59254

<400>  6720
auggcuucau auccaggcca ucaacaugca ucugcauuug aucaagcagc uagaucaaga       60

ggacauucaa auaggagaac agcuuuaaga ccaagaagac aacaagcaac ggaaguacau      120

cuagaacaaa aaaugccaac auuauuaaga guauauaucg auggaccuca cggcaugggu      180

aaaacaacaa ccacacaauu acuaguagca cuaggaagua gagacgauau aguauauguc      240

ccagaaccua ugacauauug gagaguauua ggagcaagcg aaacaauagc aaauauauau      300

acaacacaac acagauuaga ucaaggagaa auauccgcag gagaugcagc aguaguaaug      360

acaucugcac aaaucacuau gggaaugcca uaugcuguaa cagacgcagu auuagcacca      420

cauauuggag gagaagcagg uucaucgcau gcaccaccuc ccgcauuaac auuaaucuuc      480

gaccgucauc ccauagcagc acucuuaugu uauccagcag cuagguacuu aaugggaucu      540

augacaccac aagcaguccu agcuuucgua guauuaauac caccaacacu accuggaacu      600

aauaucguau uaggagcuuu accugaagau cgacauauag auagacuagc aaaaagacaa      660

agaccaggug aacgacuaga ucucgcaaug uuagcagcaa uaagaagagu auauggauua      720

cuagcaaaua ccguccgaua uuuacaaugu ggaggaucau ggcgagaaga uuggggacaa      780

uuaucuggca cagcauuaac accucaagga gcagaaccac aaucaaaugc aggaccaaga      840

ccacauauag gagaaacucu uuucaccuua uuuagagcac cagaauuacu agcaccaaau      900

ggugaucuau acaauguauu ugcuugggca uuagauguau uagcaaaaag acuacgacca      960

augcauguau ucauauuaga uuaugaucaa aguccagcug gaugcagaga ugcauuacua     1020

caauuaacaa gcggaauggu acaaacacac guaaccacac caggaucaau accuaccaua     1080

ugcgaccuag caagaacauu ugcaagagaa augggagaag cacauuaa                  1128


<210>  6721
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPP9

<400>  6721

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val His Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Asn Met Thr Pro Gln Ala Val Leu Ala Phe Val Val 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6722
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6722
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

caccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcggua ccuuaugggc      540

aacaugaccc cccaggccgu gcuggcguuc gugguccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gugagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cuacuugcca auacggugcg guaucugcag ugcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccuu gacgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggaaac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca cccccggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacua a              1131


<210>  6723
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6723
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

caccucgagc agaagaugcc cacgcugcug cgggucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcuccuggug gcgcugggga gccgcgacga caucguguac      240

guccccgagc cgaugaccua cuggcgggug cucggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcgaggc cgggagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggc      540

aacaugaccc cgcaggccgu ccuggccuuc guggugcuca ucccgcccac ccugcccggc      600

accaacaucg uccugggggc gcuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gcgagcggcu ggaccucgcc augcuggccg ccauccgccg gguguacggg      720

cugcucgcga acacggugcg cuaccugcag ugcggcggca gcuggcggga ggacuggggg      780

cagcuguccg gcaccgcccu cacgccccag ggggccgagc cccagagcaa cgccggcccg      840

cgcccccaca ucggggagac ccuguucacc cuguuccgcg cgcccgagcu ccuggccccc      900

aacggcgacc uguacaacgu cuucgccugg gcccucgacg ugcuggccaa gcggcugcgc      960

ccgaugcacg uguucauccu cgacuacgac cagucccccg cgggcugccg ggacgcccug     1020

cugcagcuca ccagcgggau gguccagacc cacgugacca cgcccggcuc cauccccacc     1080

aucugcgacc uggcccgcac cuucgcccgg gagauggggg aggccaacug a              1131


<210>  6724
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6724
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

caccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

aacaugaccc cccaggccgu ccucgccuuc gucguccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ugcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgcccu caccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgagac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6725
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6725
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc aacucuucug agggucuaua ucgauggacc gcacgguaug      180

ggcaaaacga ccacaacuca auuguuaguu gcacugggga gucgggacga uauuguguac      240

guacccgaac cuaugaccua uuggcgcgug cuaggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcauagacu cgaccagggc gaaauuuccg ccggugaugc cgcugucgug      360

augacaucug cccagaucac cauggggaug ccauaugcgg uuacggacgc agugcuggca      420

ccccacauug gaggcgaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc auccuauagc ugccuugcuc ugcuacccag cggcccggua ucugaugggg      540

aacaugaccc cgcaagcagu ccuggcuuuc gugguacuca uucccccuac auuaccagga      600

acuaauaucg uucugggugc ccuucccgag gaccgccaca ucgaucgauu ggcuaagaga      660

cagaggccug gcgaacggcu ggaccuagcc augcucgcag ccauucgucg cguguacggg      720

cugcuugcua acaccgucag auaccugcag uguggaggca gcuggaggga ggauuggggu      780

caguugagug ggacagcgcu caccccacaa ggagcagaac cccaguccaa ugccggcccg      840

cggccucaua ucggcgagac gcuguuuacu uuauuccgag cucccgagcu gcucgcccca      900

aacggggacc uuuauaaugu guuugcaugg gcccuggaug uguuggcuaa acgccuaaga      960

ccuaugcacg ucuucauacu ggacuacgac cagucucccg ccggaugcag ggaugcacuc     1020

cugcaacuua caagcgguau gguucagacc cacgugacua caccaggcuc cauucccacc     1080

aucugugacc uggcgcggac guuugcucgc gaaauggggg aggccaacug a              1131


<210>  6726
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6726
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

caccuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

aacaugaccc cccaggccgu gcuggccuuc guggugcuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ugcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgcccu gaccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgagac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6727
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6727
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc gacgcugcuu cgggucuaua ucgauggacc ccacggcaug      180

gggaaaacca caaccacaca acugcucguu gcucugggau cccgcgacga uauuguguac      240

gugccugaac ccaugaccua uuggagaguc cuuggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaucggcu ggaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaugggcaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccacaucg gcggggaggc cggaucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc auccuauugc cgcucuccug ugcuaccccg ccgccagaua ucuuaugggc      540

aacaugaccc cucaagcugu gcuggcguuc guugugcuca uucccccgac gcugccuggg      600

acaaauaucg uccuuggagc ccugcccgag gaccggcaca ucgaucgccu cgcuaagaga      660

cagcggccug gcgaacgccu ggaccuggcc augcucgccg cuauuagacg gguguacggg      720

cugcuugcca acaccgugag auaccugcag uguggaggcu ccuggcgcga ggauuggggc      780

cagcucagcg ggacagcgcu gacaccccaa ggagcugaac cccagucuaa ugccggcccu      840

cggccgcaua ucggggagac ccuuuuuacc cuguucagag cccccgagcu ccuggcuccu      900

aacggagacc uguauaaugu cuuugccugg gcucucgaug uucuggccaa acgccuucgg      960

cccaugcacg uguucauucu ggacuacgac caguccccug cgggcugcag agaugcccuc     1020

cugcaacuua cgagcgggau ggugcagacc cacgucacaa cccccggauc uaucccgaca     1080

aucugugacc uggcucgcac cuuugcccgg gaaaugggcg aggcuaacug a              1131


<210>  6728
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59255

<400>  6728
auggcaucau acccaggaca ccaacacgcc agugcuuuug aucaagcugc aagaaguaga       60

ggacauucaa auagaagaac ugcauuaaga ccaagaagac aacaagaagc aacagaagua      120

cauuuagaac aaaaaaugcc uacacuauua agaguauaua ucgauggacc ucauggaaug      180

gguaaaacua cuacaacaca auuacuagua gcucuaggca guagagauga cauuguauau      240

guaccagaac cuaugacaua uuggagagua cuaggagcau cagaaacaau agcaaacauu      300

uauacaacac aacauagacu cgaucaagga gaaauaagcg caggcgaugc agcaguagua      360

augacaucug cacaaauuac uaugggaaug cccuaugccg uaacagacgc uguacuagcc      420

ccucauauug guggagaagc gggaagcuca caugcaccac caccagcacu caccuuaaua      480

uuugacagac auccaauugc agcauuauua uguuauccag cagcaagaua ucuaauggga      540

aauaugacuc cacaagcagu auuagcauuc guuguacuaa uaccuccaac auuaccagga      600

acaaacauag uuuuaggagc auuaccugaa gauagacaca uagauagauu agcaaaaaga      660

caaagaccag gagaacgacu agaccuagca augcuagcag caauaagaag aguauauggu      720

uuauuagcaa auacaguacg auaucuucaa ugugguggau cauggagaga agauugggga      780

caauuaagug gaaccgcauu aacaccacaa ggagcagaac cacaaucaaa cgcaggacca      840

agaccacaca uaggcgaaac auuauucaca uuauuuagag caccagaacu auuagcccca      900

aauggagauc uguauaaugu cuucgcuugg gcauuagaug uauuagcaaa aagauuaaga      960

ccuaugcaug uauuuauauu agacuaugau caaaguccag cuggauguag agacgcauua     1020

uuacaauuaa caucaggaau gguacaaacu cauguaacaa caccuggaag uauacccaca     1080

auaugugacu uagccagaac auuugcacga gaaaugggag aagccaauua a              1131


<210>  6729
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPQ0

<400>  6729

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Asn Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Lys Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro 
        195                 200                 205             


Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu 
    210                 215                 220                 


Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Glu Leu 
225                 230                 235                 240 


Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg Glu 
                245                 250                 255     


Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala Glu 
            260                 265                 270         


Pro Gln Ser Asn Ala Gly Pro Gln Pro His Ile Gly Asp Thr Leu Phe 
        275                 280                 285             


Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr 
    290                 295                 300                 


Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Pro 
305                 310                 315                 320 


Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg 
                325                 330                 335     


Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr 
            340                 345                 350         


Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala 
        355                 360                 365             


Arg Glu Met Gly Glu Ala Asn 
    370                 375 


<210>  6730
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6730
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauaaca accgacguac ggcguugcgc ccucgccggc agcaaaaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug uguuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccucc cgccgaccuu gcccggcaca      600

aacaucgugu ugggggcccu uccggaggac agacacaucg accgccuggc caaacgccag      660

cgccccggcg agcggcuuga ccuggcuaug cuggccgcga uucgccgcgu uuacgagcug      720

cuugccaaua cggugcggua ucugcagggc ggcgggucgu ggcgggagga uuggggacag      780

cuuucgggga cggccgugcc gccccagggu gccgagcccc agagcaacgc gggcccacaa      840

ccccauaucg gggacacguu auuuacccug uuucgggccc ccgaguugcu ggcccccaac      900

ggcgaccugu auaacguguu ugccugggcc uuggacgucu uggccaaacg ccuccguccc      960

augcacgucu uuauccugga uuacgaccaa ucgcccgccg gcugccggga cgcccugcug     1020

caacuuaccu ccgggauggu ccagacccac gucaccaccc ccggcuccau accgacgauc     1080

ugcgaccugg cgcgcacguu ugcccgggag augggggagg cuaacuaa                  1128


<210>  6731
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6731
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacaaca accgccggac cgcccugcgc ccgcggcgcc agcagaaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggcu cccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcgcgug cucggggcca gcgagaccau cgccaacauc      300

uacaccacgc agcaccggcu ggaccagggc gagaucuccg ccggcgacgc ggccgugguc      360

augaccagcg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcuccagc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccgcc accccaucgc cgcccugcuc ugcuaccccg ccgcccggua ccugaugggg      540

uccaugaccc cgcaggccgu ccuggccuuc guggcgcucc cgcccacccu gcccggcacc      600

aacaucgugc ugggcgcccu ccccgaggac cgccacaucg accggcuggc caagcgccag      660

cggcccgggg agcgccugga ccucgccaug cuggccgcga uccggcgcgu cuacgagcug      720

cucgccaaca cggugcggua ccugcagggc gggggcagcu ggcgcgagga cuggggccag      780

cuguccggga ccgccgugcc gccccagggc gccgagcccc agagcaacgc ggggccccag      840

ccccacaucg gcgacacccu cuucacccug uuccgcgccc ccgagcugcu cgccccgaac      900

ggggaccugu acaacgucuu cgccugggcc cuggacgugc ucgcgaagcg gcugcgcccc      960

augcacgugu ucauccugga cuacgaccag ucccccgccg gcugccggga cgcccuccug     1020

cagcugacga gcggcauggu ccagacccac gugaccaccc ccggguccau cccgacgauc     1080

ugcgaccucg cccgcaccuu cgcccgggag augggcgagg cgaacuga                  1128


<210>  6732
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6732
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacaaca accgccgcac cgcccuccgc ccccgccgcc agcagaaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccucc cccccacccu ccccggcacc      600

aacaucgucc ucggcgcccu ccccgaggac cgccacaucg accgccucgc caagcgccag      660

cgccccggcg agcgccucga ccucgccaug cucgccgcca uccgccgcgu cuacgagcuc      720

cucgccaaca ccguccgcua ccuccagggc ggcggcuccu ggcgcgagga cuggggccag      780

cucuccggca ccgccguccc cccccagggc gccgagcccc aguccaacgc cggcccccag      840

ccccacaucg gcgacacccu cuucacccuc uuccgcgccc ccgagcuccu cgcccccaac      900

ggcgaccucu acaacgucuu cgccugggcc cucgacgucc ucgccaagcg ccuccgcccc      960

augcacgucu ucauccucga cuacgaccag ucccccgccg gcugccgcga cgcccuccuc     1020

cagcucaccu ccggcauggu ccagacccac gucaccaccc ccggcuccau ccccaccauc     1080

ugcgaccucg cccgcaccuu cgcccgcgag augggcgagg ccaacuga                  1128


<210>  6733
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6733
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacaaca aucggcgcac cgcucugcga ccucguagac agcagaaggc cacagaggug      120

aggcucgaac agaaaaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaagacga ccacaacuca auuguuaguu gcacugggcu cacgcgacga uauuguguac      240

guacccgagc cuaugaccua uuggagagug cuaggggcca gugaaacaau agcuaacauc      300

uacaccacuc agcacaggcu cgaccaggga gagauuagcg caggcgaugc cgcugucgug      360

augacauccg cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaagc ugggucuucg cacgccccuc cacccgcacu uacucugauc      480

uuugaucggc acccuauagc ugccuugcuc uguuacccag cggcccgcua ucugaugggc      540

ucaaugaccc cgcaagcagu ccuggcuuuc guggccuuac ccccuacacu cccaggcacu      600

aauaucguac ugggagcccu ucccgaggac cgacauauug auagauuggc caaaaggcag      660

cggccuggug agcgucugga ccuagcaaug cucgccgcua uccgcagagu uuacgaacug      720

cuugcgaaca ccgugaggua ccugcagggc gggggaagcu ggcgggagga uuggggccag      780

uugaguggua cagcaguccc accccaaggg gccgaaccgc aguccaaugc uggaccucag      840

ccccacauug gcgacacccu cuuuacgcug uuccgagccc cagaguuacu ggcaccuaac      900

ggcgaucucu auaauguguu ugccugggcu cuugacgugc uggccaagcg cuugagaccc      960

augcaugucu ucauccuaga cuacgaucaa ucuccagcag ggugcaggga cgcgcugcuc     1020

cagcugacua gcggaauggu ucagacacac gugaccacuc ccgguuccau accuacaauu     1080

ugugaucuug cucggaccuu ugcccgcgag augggcgaag caaacuga                  1128


<210>  6734
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6734
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacaaca acagaagaac cgcccugaga cccagaagac agcagaaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccugc cccccacccu gcccggcacc      600

aacaucgugc ugggcgcccu gcccgaggac agacacaucg acagacuggc caagagacag      660

agacccggcg agagacugga ccuggccaug cuggccgcca ucagaagagu guacgagcug      720

cuggccaaca ccgugagaua ccugcagggc ggcggcagcu ggagagagga cuggggccag      780

cugagcggca ccgccgugcc cccccagggc gccgagcccc agagcaacgc cggcccccag      840

ccccacaucg gcgacacccu guucacccug uucagagccc ccgagcugcu ggcccccaac      900

ggcgaccugu acaacguguu cgccugggcc cuggacgugc uggccaagag acugagaccc      960

augcacgugu ucauccugga cuacgaccag agccccgccg gcugcagaga cgcccugcug     1020

cagcugacca gcggcauggu gcagacccac gugaccaccc ccggcagcau ccccaccauc     1080

ugcgaccugg ccagaaccuu cgccagagag augggcgagg ccaacuga                  1128


<210>  6735
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6735
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacaaca aucgcagaac cgcccugcgg ccucgcagac agcagaaggc cacagaggug      120

cggcucgaac agaaaaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaagacca caaccacaca acugcucguu gcucugggga gcagagacga uauuguguac      240

gugccugagc ccaugaccua uuggcggguc cuuggagccu ccgaaacaau cgcuaacauu      300

uacaccacgc agcaccgccu ggaccagggc gagaucucug ccggggaugc ggccgugguu      360

augaccagcg cucagauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaagc cggguccucu cacgccccuc cgcccgcucu gacacugauc      480

uuugauagac acccuauugc cgcucuccug uguuaccccg ccgcccggua ucuuauggga      540

agcaugaccc cucaagcugu gcuggcguuc guugcccugc ccccgacgcu cccuggcaca      600

aauaucgugc uuggggcucu gcccgaggac cgccauauug auagacucgc caaacggcag      660

cgcccuggag agagacugga ccuggccaug cucgcugcca uccggagagu cuacgaacug      720

cuugcgaaca ccgugcgcua ccugcagggc gggggauccu ggcgggagga uuggggccag      780

cucagcggca cagcugugcc uccccaaggg gccgaacccc agucuaaugc cggaccgcag      840

ccccacauug gcgacacccu guuuacccuu uucagagcuc cugagcugcu cgcccccaac      900

ggggaucugu auaaugucuu ugcuugggcc cuggacguuc ucgcgaagcg ccugcggccu      960

augcaugugu ucauccuuga cuacgaucaa ucccccgccg gaugcagaga cgcucugcuc     1020

cagcugacaa gcggcauggu gcagacgcac gucaccacac cggggucuau uccuaccauc     1080

ugugaucuug cccgcacauu ugcucgggag augggagaag ccaacuga                  1128


<210>  6736
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59256

<400>  6736
auggcuucau auccauguca ucaacaugca uccgcauuug aucaagcagc aagaucaaga       60

ggacauaaua aucgaagaac agcccuuaga ccaagaagac aacaaaaagc uacagaaguu      120

agauuagaac aaaaaaugcc aacauuauua agaguauaua uagauggacc acaugguaug      180

gguaaaacua caacaacaca auuacucguu gcauuaggau caagggacga cauaguauac      240

guaccagaac caaugacaua cuggagagua cucggcgcua gugaaacgau ugcuaauaua      300

uauacaacac aacacagauu agaccaagga gaaauaucag caggagaugc agcaguaguu      360

augacaucag cucaaauaac aauggguaug ccauaugcag uaacagaugc gguccuagca      420

ccacauauug gcggcgaagc uggaucauca cacgcaccac caccagcauu aacauuaaua      480

uuugauagac auccaauagc cgcauuauua uguuauccag cagcuagaua ucuaauggga      540

uccaugacac cacaagcagu auuagcuuuu guagcauuac caccuacuuu accagggaca      600

aauauaguuc uaggugcuuu accagaagau agacauauag auagacuagc aaaaagacaa      660

cgaccaggag aaagauuaga uuuagcaaug uuagcagcaa uaagaagagu uuacgaacua      720

uuagcaaaua caguuagaua ucuacaagga ggaggaucau ggagagaaga uuggggacaa      780

uuaucuggaa cagcaguacc accacaagga gcagaaccac aauccaaugc aggaccucaa      840

ccacauauag gagauacacu auuuacauua uucagagcac cagaauuauu agcaccaaau      900

ggugaucuau auaauguuuu ugcaugggcu cuagauguau uagcaaaaag auuaagacca      960

augcauguau uuauauuaga uuaugaucaa ucaccagcug guuguagaga ugcacuacua     1020

caauuaacau cagguauggu ucaaacucac guuaccacac caggcaguau accaacaaua     1080

ugugaucuag caagaacauu ugcacgagaa augggagaag caaauuaa                  1128


<210>  6737
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPQ2

<400>  6737

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Gly Gly Trp Glu Leu Thr Cys Pro Ala Pro Gly Pro His Pro His 
145                 150                 155                 160 


Leu Arg Pro Pro Ser His Arg Arg Pro Pro Val Leu Pro Gly Arg Ala 
                165                 170                 175     


Ile Pro Tyr Gly Gln His Asp Pro Pro Gly Arg Ala Gly Val Arg Gly 
            180                 185                 190         


Pro His Pro Ala Asp Leu Ala Arg His Lys His Arg Val Gly Gly Pro 
        195                 200                 205             


Ser Gly Gly Gln Thr His Arg Pro Pro Gly Gln Thr Pro Ala Pro Arg 
    210                 215                 220                 


Arg Ala Ala 
225         


<210>  6738
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6738
auggcuucgu accccggcca ucagcacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgcccggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg gggggggagg cugggagcuc acaugccccg cccccggccc ucacccucau      480

cuucgaccgc caucccaucg ccgcccuccu guguuacccg gccgcgcgau accuuauggg      540

cagcaugacc ccccaggccg ugcuggcguu cguggcccuc aucccgccga ccuugcccgg      600

cacaaacauc guguuggggg cccuuccgga ggacagacac aucgaccgcc uggccaaacg      660

ccagcgcccc ggcgagcggc uuga                                             684


<210>  6739
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6739
auggccagcu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcccgagc agaagaugcc cacgcuccug cgcguguaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcugcucgug gcgcugggga gccgggacga caucguguac      240

gucccggagc ccaugaccua cuggcagguc cugggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu cgaccagggc gagaucagcg ccggggacgc ggccguggug      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcggggg cugggagcug acgugcccgg cccccggccc ccacccccac      480

cuccggccgc ccagccaccg ccggccgccc guccugcccg ggcgcgccau ccccuacggc      540

cagcacgacc cgcccgggcg ggccggcgug cgcggccccc accccgccga ccuggcgcgg      600

cacaagcacc gcgucggggg ccccuccggg ggccagaccc accggccccc ggggcagacc      660

cccgcgcccc gccgggccgc cuga                                             684


<210>  6740
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6740
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccccgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcggcgg cugggagcuc accugccccg cccccggccc ccacccccac      480

cuccgccccc ccucccaccg ccgccccccc guccuccccg gccgcgccau ccccuacggc      540

cagcacgacc cccccggccg cgccggcguc cgcggccccc accccgccga ccucgcccgc      600

cacaagcacc gcgucggcgg ccccuccggc ggccagaccc accgcccccc cggccagacc      660

cccgcccccc gccgcgccgc cuga                                             684


<210>  6741
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6741
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggccagagc agaagaugcc gacucuccuu cgggucuaua ucgauggacc ccaugguaug      180

ggcaaaacga ccacaacuca acuguugguu gcauuaggga gucgcgacga uauuguguac      240

guaccugaac caaugaccua uuggcaagug cugggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu agaccagggc gaaauuuccg ccggugaugc agcugucgug      360

augacaucug cccagaucac cauggggaug cccuaugcgg uuacggacgc agugcucgcc      420

ccucauauug gaggcggcgg gugggagcug acuugcccag cucccggacc ucacccacac      480

cuuaggccgc ccucgcaucg gcgcccucca guccugcccg gucgagccau cccuuacggc      540

cagcacgauc cacccgggag agcaggagug aggggcccgc auccugcuga cuuggcccgg      600

cacaagcacc guguaggugg gcccucagga ggccagaccc aucgcccacc uggccagaca      660

cccgcgccaa gaagggccgc auga                                             684


<210>  6742
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6742
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacccgagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcggcgg cugggagcug accugccccg cccccggccc ccacccccac      480

cugagacccc ccagccacag aagacccccc gugcugcccg gcagagccau ccccuacggc      540

cagcacgacc cccccggcag agccggcgug agaggccccc accccgccga ccuggccaga      600

cacaagcaca gagugggcgg ccccagcggc ggccagaccc acagaccccc cggccagacc      660

cccgccccca gaagagccgc cuga                                             684


<210>  6743
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6743
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggccggagc agaagaugcc cacgcuccug cgcgucuaua ucgauggacc ucauggcaug      180

gggaaaacca caaccacaca acuucugguu gcucucggau ccagagacga uauuguguac      240

gugcccgaac cuaugaccua uuggcagguc cugggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ugaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggcaug cccuaugccg ugaccgacgc uguccuggcc      420

ccucauaucg gcgggggagg cugggagcuc acaugcccgg cgcccgggcc ucacccccau      480

cugcgcccuc ccucucacag acggccgccu gugcugcccg gacgcgccau cccuuacggc      540

cagcacgauc cucccgggag agcuggaguu cggggccccc auccggccga ccucgcucgc      600

cacaagcaca gagugggcgg gcccagcgga ggccagaccc aucggccucc cgggcagacg      660

ccugccccca gacgcgccgc uuga                                             684


<210>  6744
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59258

<400>  6744
auggcaucau auccaggaca ucaacaugca agcgcauuug aucaagcagc aagaagcaga       60

ggacauucaa aucgaagaac agcuuuaaga ccaagaagac aacaagaagc aacagaagua      120

agaccagaac aaaaaaugcc aacauuacua agaguuuaua uagauggucc ccauggaaug      180

gguaaaacaa cuacuacaca auuauuagua gcauuaggau caagagauga uauaguauac      240

guuccagaac caaugacaua uuggcaagua uuaggagcau cagaaacaau cgcaaauaua      300

uacaccacac aacauagauu agaucaagga gaaauaagug caggugaugc agcaguaguu      360

augacaagug cucaaauaac uaugggaaug ccauaugcag uaacagaugc aguauuagca      420

ccacauauag gaggaggagg augggaauua acauguccag caccaggacc acauccacau      480

uuaagaccac ccucucauag aagaccacca guucuaccag gaagagcaau accauaugga      540

caacaugacc caccaggaag agcaggagua agaggaccac auccagcaga uuuagcacga      600

cauaaacaca gaguuggagg accaucagga ggacaaacuc aucgcccacc uggacaaaca      660

ccagcaccaa gaagagcagc auaa                                             684


<210>  6745
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPQ3

<400>  6745

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Gly Gly Trp Glu Leu Thr Cys Pro Ala Pro Gly Pro His Pro His 
145                 150                 155                 160 


Leu Arg Pro Pro Ser His Arg Arg Pro Pro Val Leu Pro Gly Arg Ala 
                165                 170                 175     


Ile Pro Tyr Gly Gln His Asp Pro Pro Gly Arg Ala Gly Val Arg Gly 
            180                 185                 190         


Pro His Pro Ala Asp Leu Ala Arg His Lys His Arg Val Gly Gly Pro 
        195                 200                 205             


Ser Gly Gly Gln Thr His Arg Pro Pro Gly Gln Thr Pro Ala Pro Arg 
    210                 215                 220                 


Arg Ala Ala 
225         


<210>  6746
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6746
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgcccggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg gggggggagg cugggagcuc acaugccccg cccccggccc ucacccucau      480

cuucgaccgc caucccaucg ccgcccuccu guguuacccg gccgcgcgau accuuauggg      540

cagcaugacc ccccaggccg ugcuggcguu cguggcccuc aucccgccga ccuugcccgg      600

cacaaacauc guguuggggg cccuuccgga ggacagacac aucgaccgcc uggccaaacg      660

ccagcgcccc ggcgagcggc uuga                                             684


<210>  6747
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6747
auggccagcu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcccgagc agaagaugcc cacgcuccug cgcguguaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcugcucgug gcgcugggga gccgggacga caucguguac      240

gucccggagc ccaugaccua cuggcgcgug cugggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccggcu cgaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcggggg cugggagcug acgugcccgg cccccggccc ccacccccac      480

cuccgcccgc ccagccaccg gcgcccgccc guccugcccg ggcgggccau ccccuacggc      540

cagcacgacc cgcccgggcg cgccggcgug cggggccccc accccgccga ccuggcgcgc      600

cacaagcacc gggucggggg ccccuccggg ggccagaccc accggccccc ggggcagacc      660

cccgcgcccc gccgcgccgc cuga                                             684


<210>  6748
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6748
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccccgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcggcgg cugggagcuc accugccccg cccccggccc ccacccccac      480

cuccgccccc ccucccaccg ccgccccccc guccuccccg gccgcgccau ccccuacggc      540

cagcacgacc cccccggccg cgccggcguc cgcggccccc accccgccga ccucgcccgc      600

cacaagcacc gcgucggcgg ccccuccggc ggccagaccc accgcccccc cggccagacc      660

cccgcccccc gccgcgccgc cuga                                             684


<210>  6749
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6749
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggccagagc agaagaugcc gacucuccuu cgggucuaua ucgauggacc ccaugguaug      180

ggcaaaacga ccacaacuca acuguugguu gcauuaggga gucgcgacga uauuguguac      240

guaccugaac caaugaccua uuggagagug cugggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcacaggcu agaccagggc gaaauuuccg ccggugaugc agcugucgug      360

augacaucug cccagaucac cauggggaug cccuaugcgg uuacggacgc agugcucgcc      420

ccucauauug gaggcggcgg gugggagcug acuugcccag cucccggacc ucacccacac      480

cuucggccgc ccucgcaucg ccgaccucca guccugcccg guagagccau cccuuacggc      540

caacacgauc cacccgggag ggcaggagug cggggcccgc auccugcuga cuuggcccgu      600

cacaagcacc gcguaggugg gcccucagga ggccagaccc auagaccacc uggccagaca      660

cccgcgccaa ggcgggccgc auga                                             684


<210>  6750
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6750
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacccgagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcggcgg cugggagcug accugccccg cccccggccc ccacccccac      480

cugagacccc ccagccacag aagacccccc gugcugcccg gcagagccau ccccuacggc      540

cagcacgacc cccccggcag agccggcgug agaggccccc accccgccga ccuggccaga      600

cacaagcaca gagugggcgg ccccagcggc ggccagaccc acagaccccc cggccagacc      660

cccgccccca gaagagccgc cuga                                             684


<210>  6751
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6751
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggccggagc agaagaugcc cacgcuccug cgcgucuaua ucgauggacc ucauggcaug      180

gggaaaacca caaccacaca acuucugguu gcucucggau ccagagacga uauuguguac      240

gugcccgaac cuaugaccua uuggcggguc cugggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccgccu ugaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaugggcaug cccuaugccg ugaccgacgc uguccuggcc      420

ccucauaucg gcgggggagg cugggagcuc acaugcccgg cgcccgggcc ucacccccac      480

cugagaccuc ccucucaucg gcgcccgccu gugcugcccg gacgcgccau cccuuacggc      540

caacacgauc cucccgggcg ggcuggaguu cgcggccccc auccggccga ccucgcuaga      600

cacaagcacc gggugggcgg gcccagcgga ggccagaccc auagaccucc cgggcagacg      660

ccugccccca gacgggccgc uuga                                             684


<210>  6752
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59259

<400>  6752
auggcaucau auccagguca ccaacacgcu ucagcauuug aucaagcagc aagaucaaga       60

ggacauagua auagaagaac agcauuaaga ccaagaagac aacaagaagc aacagaagua      120

agaccagaac aaaaaaugcc aacauuacua agaguauaua uagauggacc ucacggaaug      180

gguaaaacaa caacaacaca auuauuagua gcacuaggau caagagauga uauaguauau      240

guaccagaac caaugacaua uuggagagua cuaggagcau cagaaacaau agcaaauaua      300

uauacaacac aacauagacu agaucaagga gaaauaucag caggugacgc agcaguagua      360

augacaagcg cacaaauaac aaugggaaug ccauaugcag uaacagaugc uguauuagca      420

ccacauauag gaggaggagg augggaauua acauguccag caccaggacc ucacccucau      480

cuaagaccac caucacauag gagaccacca guauuaccag gaagagcaau accauaugga      540

caacaugauc caccaggaag agcaggugua agaggaccac auccagcaga uuuagcaaga      600

cauaaacaua gaguaggugg gccaagcgga ggacaaacac aucgaccacc aggucaaaca      660

ccagcuccaa gaagggcagc auaa                                             684


<210>  6753
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPQ4

<400>  6753

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ser Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Val 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6754
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6754
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uagcgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcggua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc gugguccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gugagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cuacuugcca auacggugcg guaucugcag ugcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccuu gacgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggaaac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc caugucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacua a              1131


<210>  6755
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6755
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcuccuggug gcgcugggga gccgggacga cuccguguac      240

guccccgagc cgaugaccua cuggcgcgug cucggcgcca gcgagaccau cgccaacauc      300

uacaccacgc agcaccggcu ggaccagggc gagaucuccg ccggggacgc ggccgugguc      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcgaggc cggguccagc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccgcc accccaucgc cgcccugcuc ugcuaccccg ccgcccggua ccugaugggc      540

uccaugaccc cgcaggccgu ccuggccuuc guggugcuca ucccgcccac ccugcccggc      600

accaacaucg uccugggggc gcuccccgag gaccgccaca ucgaccggcu ggccaagcgc      660

cagcggcccg gcgagcgccu ggaccucgcc augcuggccg ccauccggcg cguguacggg      720

cugcucgcga acacggugcg guaccugcag ugcggcggca gcuggcgcga ggacuggggg      780

cagcuguccg gcaccgcccu cacgccccag ggggccgagc cccagagcaa cgccggcccg      840

cgcccccaca ucggggagac ccuguucacc cuguuccggg cgcccgagcu ccuggccccc      900

aacggcgacc uguacaacgu cuucgccugg gcccucgacg ugcuggccaa gcgccugcgg      960

ccgaugcacg uguucauccu cgacuacgac cagucccccg cgggcugccg cgacgcccug     1020

cugcagcuca ccagcgggau gguccagacc cacgugacca cgcccggcuc cauccccacc     1080

aucugcgacc uggcccggac cuucgcccgc gagauggggg aggccaacug a              1131


<210>  6756
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6756
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga cuccgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucguccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ugcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgcccu caccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgagac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6757
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6757
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgauggacc gcaugguaug      180

ggcaaaacga ccacaacuca auuguuaguu gcacugggga gucgcgacga uagcguguac      240

guacccgaac cuaugaccua uuggagagug cuaggagccu ccgagacaau ugcuaauaua      300

uacaccacuc agcacaggcu cgaccagggc gaaaucucug ccggugaugc cgcugucgug      360

augacaucgg cccagauuac cauggggaug ccauaugcgg uuacggacgc agugcuggca      420

ccccauaucg gaggcgaggc uggcucaagc cacgccccuc cacccgcacu uacucugauu      480

uuugaucggc acccuaucgc ugccuugcuc ugcuacccag cggcccgcua ucugaugggg      540

aguaugaccc cgcaagcagu ccuggcuuuc gugguacuca uacccccuac auuaccagga      600

acuaacaucg uucugggugc ccuucccgag gaccgacaua uugauagauu ggcuaagagg      660

cagcggccug gcgaacgucu ggaccuagcc augcucgcag ccauccgcag aguguacggg      720

cugcuugcua auaccgucag guaccugcag uguggaggcu ccuggcggga ggauuggggu      780

caguugucug ggacagcgcu caccccacaa ggagcagaac cccagagcaa cgccggcccg      840

cgaccucaca uuggcgagac gcuguuuacu uuauuccgcg cucccgagcu gcucgcccca      900

aauggggacc uuuauaacgu guuugcaugg gcccuggaug uguuggcuaa aagacuaagg      960

ccuaugcaug ucuucauccu ggacuacgac cagucccccg ccggaugccg ggaugcacuc     1020

cugcaacuua caucagguau gguucagacc cacgugacua caccaggcag uauacccacc     1080

auuugugacc uggcgcgcac guuugcuaga gaaauggggg aggccaauug a              1131


<210>  6758
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6758
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga cagcguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggugcuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ugcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgcccu gaccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgagac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6759
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6759
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgauggacc ccauggcaug      180

gggaaaacca caaccacaca acugcucguu gcucugggau ccagagacga uucuguguac      240

gugccugaac ccaugaccua uuggcggguc cuuggcgcca gcgagacaau ugcuaauauc      300

uacaccacgc agcaccgccu ggaccagggg gaaauuuccg ccggagaugc ggccgugguu      360

augaccucug cucagaucac aaugggcaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauauug gcggggaggc cggaagcucc cacgccccuc cgcccgcucu gacacugauc      480

uuugauagac acccuaucgc cgcucuccug ugcuaccccg ccgcccggua ucuuaugggc      540

agcaugaccc cucaagcugu gcuggcguuc guugugcuca uucccccgac gcugccuggg      600

acaaacaucg uccuuggagc ccugcccgag gaccgccaua uugauagacu cgcuaagcgg      660

cagcgcccug gcgaaagacu ggaccuggcc augcucgccg cuauccggag aguguacggg      720

cugcuugcca auaccgugcg cuaccugcag uguggaggcu cuuggcggga ggauuggggc      780

cagcucuccg ggacagcgcu gacaccccaa ggagcugaac cccagagcaa cgccggcccu      840

agaccgcaca uuggggagac ccuuuuuacc cuguuccgcg cccccgagcu ccuggcuccu      900

aauggagacc uguauaacgu cuuugccugg gcucucgaug uucuggccaa acggcuuaga      960

cccaugcaug uguucauccu ggacuacgac cagucuccug cgggcugccg cgaugcccuc     1020

cugcaacuua cguccgggau ggugcagacc cacgucacaa cccccggaag cauuccgaca     1080

aucugugacc uggcucggac cuuugccaga gaaaugggcg aggcuaauug a              1131


<210>  6760
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59260

<400>  6760
auggccagcu auccagguca ucaacaugca agugcauuug accaagcagc aagaucaaga       60

ggucauucaa auagaaggac agcucuaaga ccuagaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacauuauua agaguauaua uagauggacc acauggaaug      180

ggaaaaacaa caaccacaca auuauuagua gcuuuaggau caagagauga cucaguauau      240

guaccagagc caaugacgua uuggagagua cuaggagcaa gcgaaacaau agcaaauaua      300

uacacaacac aacauagauu agaucaagga gaaauaagcg caggagaugc agcaguagua      360

augaccagug cacaaauaac aaugggaaug ccuuaugcag uuaccgaugc aguauuagcc      420

ccacauauag guggugaagc agguaguuca caugcaccac caccugcguu aacauuaauu      480

uuugaucgac acccaauagc cgcccuacua ugcuaccccg cagcaagaua ucuaauggga      540

aguaugacac cacaagcagu auuagcauuu guaguuuuaa uaccuccuac cuuaccagga      600

acaaauauag uauuaggagc auugccugaa gacagacaua uagaccgauu agcaaaaaga      660

caaagaccag gagaaagacu agaucuagcu auguuagcag caauaagacg aguauacgga      720

cuauuagcaa acacaguuag auauuuacaa uguggaggau cguggagaga agauugggga      780

caauuaagug gaacagcauu aacaccacaa ggagcagaac cacaaagcaa cgcaggacca      840

agaccacaca uaggcgaaac auuguuuaca cuauuuagag caccagaauu auuagcacca      900

aacggagauc uauauaacgu auuugccugg gcauuagaug uuuuagcaaa aagauuaaga      960

ccaaugcaug uauuuauucu agauuaugau caaucaccgg caggauguag agaugcauua     1020

uuacaacuua caagcggaau gguacaaaca caugugacaa caccaggauc aauaccaaca     1080

auaugugacc uugcaagaac auuugcaaga gaaaugggug aagcuaauua a              1131


<210>  6761
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__B2CPQ5

<400>  6761

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val His Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Val 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asn Trp Gly Gln Leu Ser Gly Thr Ala Leu Thr Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Glu Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6762
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6762
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

caccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcggua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc gugguccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gugagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cuacuugcca auacggugcg guaucugcag ugcggcgggu cguggcggga gaauugggga      780

cagcuuucgg ggacggccuu gacgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggaaac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca cccccggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacua a              1131


<210>  6763
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6763
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

caccucgagc agaagaugcc cacgcugcug cgggucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcuccuggug gcgcugggga gccgcgacga caucguguac      240

guccccgagc cgaugaccua cuggcgggug cucggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcgaggc cgggagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggc      540

agcaugaccc cgcaggccgu ccuggccuuc guggugcuca ucccgcccac ccugcccggc      600

accaacaucg uccugggggc gcuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gcgagcggcu ggaccucgcc augcuggccg ccauccgccg gguguacggg      720

cugcucgcga acacggugcg cuaccugcag ugcggcggcu ccuggcggga gaacuggggg      780

cagcugagcg gcaccgcccu cacgccccag ggggccgagc cccaguccaa cgccggcccg      840

cgcccccaca ucggggagac ccuguucacc cuguuccgcg cgcccgagcu ccuggccccc      900

aacggcgacc uguacaacgu cuucgccugg gcccucgacg ugcuggccaa gcggcugcgc      960

ccgaugcacg uguucauccu cgacuacgac cagagccccg cgggcugccg ggacgcccug     1020

cugcagcuca ccuccgggau gguccagacc cacgugacca cgcccggcag cauccccacc     1080

aucugcgacc uggcccgcac cuucgcccgg gagauggggg aggccaacug a              1131


<210>  6764
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6764
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

caccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucguccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ugcggcggcu ccuggcgcga gaacuggggc      780

cagcucuccg gcaccgcccu caccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgagac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6765
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6765
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc aacucuucug agggucuaua ucgauggacc gcacgguaug      180

ggcaaaacga ccacaacuca auuguuaguu gcacugggga gucgggacga uauuguguac      240

guacccgaac cuaugaccua uuggcgcgug cuaggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcauagacu cgaccagggc gaaauuuccg ccggugaugc cgcugucgug      360

augacaucug cccagaucac cauggggaug ccauaugcgg uuacggacgc agugcuggca      420

ccccacauug gaggcgaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc auccuauagc ugccuugcuc ugcuacccag cggcccggua ucugaugggg      540

agcaugaccc cgcaagcagu ccuggcuuuc gugguacuca uucccccuac auuaccagga      600

acuaacaucg uucugggugc ccuucccgag gaccgccaca ucgaucgauu ggcuaagaga      660

cagaggccug gcgaacggcu ggaccuagcc augcucgcag ccauucgucg cguguacggg      720

cugcuugcua auaccgucag auaccugcag uguggaggca guuggaggga gaacuggggu      780

caguuguccg ggacagcgcu caccccacaa ggagcagaac cccagucuaa ugccggcccg      840

cggccucaua ucggcgagac gcuguuuacu uuauuccgag cucccgagcu gcucgcccca      900

aacggggauc uuuauaaugu guuugcaugg gcccuggacg uguuggcuaa acgccuaaga      960

ccuaugcacg ucuucauacu ggauuacgac cagagccccg ccggaugcag ggacgcacuc     1020

cugcaacuua cauccgguau gguucagacc cacgugacua caccaggcuc aauucccacc     1080

aucugugauc uggcgcggac guuugcucgc gaaauggggg aggccaacug a              1131


<210>  6766
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6766
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

caccuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggugcuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ugcggcggca gcuggagaga gaacuggggc      780

cagcugagcg gcaccgcccu gaccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgagac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6767
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6767
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

caucucgagc agaagaugcc gacgcugcuu cgggucuaua ucgauggacc ccacggcaug      180

gggaaaacca caaccacaca acugcucguu gcucugggau cccgcgacga uauuguguac      240

gugccugaac ccaugaccua uuggagaguc cuuggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaucggcu ggaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaugggcaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccacaucg gcggggaggc cggaucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc auccuauugc cgcucuccug ugcuaccccg ccgccagaua ucuuaugggc      540

uccaugaccc cucaagcugu gcuggcguuc guugugcuca uucccccgac gcugccuggg      600

acaaacaucg uccuuggagc ccugcccgag gaccggcaca ucgaucgccu cgcuaagaga      660

cagcggccug gcgaacgccu ggaccuggcc augcucgccg cuauuagacg gguguacggg      720

cugcuugcca auaccgugag auaccugcag uguggaggca gcuggcgcga gaacuggggc      780

cagcucucug ggacagcgcu gacaccccaa ggagcugaac cccaguccaa ugccggcccu      840

cggccgcaua ucggggagac ccuuuuuacc cuguucagag cccccgagcu ccuggcuccu      900

aacggagauc uguauaaugu cuuugccugg gcucucgacg uucuggccaa acgccuucgg      960

cccaugcacg uguucauucu ggauuacgac cagagcccug cgggcugcag agacgcccuc     1020

cugcaacuua cgucugggau ggugcagacc cacgucacaa cccccggauc caucccgaca     1080

aucugugauc uggcucgcac cuuugcccgg gaaaugggcg aggcuaacug a              1131


<210>  6768
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__ACB59261

<400>  6768
auggcuaguu auccaggaca ucaacaugca ucagcauuug aucaagccgc aagaucaaga       60

ggacauucaa auagaagaac ugcacuaaga ccaagacgac aacaagaagc aacagaagua      120

caucuagaac aaaaaaugcc uacacuacua agaguauaca uagauggacc acaugguaug      180

gguaaaacaa cgaccacaca auuauuagua gcacuuggca gucgugacga uauaguauau      240

gucccagaac caaugacaua uuggagagua cuuggagcau cagaaacaau agcaaauauc      300

uauacaacac aacauagacu agaucaaggu gaaauaagug caggagaugc agcaguagua      360

augaccucag cacaaaucac aauggguaug ccauaugcag uaacagaugc aguauuagca      420

ccacacauug gaggagaagc aggaucaagu caugcaccuc caccagcauu aacacuaauu      480

uuugauagac auccaauagc agcacuacug ugcuauccag cagcucgaua cuuaauggga      540

ucaaugacac cacaagcagu ucuagccuuu guaguauuaa uaccaccaac auuaccagga      600

acaaacauag uacuaggagc acuaccagaa gauagacaua uagaucgacu agcaaaaaga      660

caaaggccag gagaacgauu agaucuugca auguuagcag caauaagaag aguauacgga      720

uuauuagcaa auacuguaag auaucuacaa ugcggagguu cauggagaga aaacugggga      780

caacuaucag gaacagcauu aacaccacaa ggagcugaac cacaaucaaa cgcaggucca      840

agaccacaua uaggagaaac acucuucacc cucuuuagag caccagaacu acuagcacca      900

aacggugauu uauauaaugu auuugcaugg gcccuagaug uauuagcaaa aagacuaaga      960

ccaaugcaug uauuuauacu agauuaugau caaucacccg caggaugucg cgaugcacua     1020

uuacaauuaa caagcgguau gguacaaaca cauguaacaa ccccaggauc aauaccaaca     1080

auuugugauu uagcaagaac auucgcaaga gaaaugggag aagcaaauug a              1131


<210>  6769
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__O72346

<400>  6769

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6770
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6770
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgcccggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacug a              1131


<210>  6771
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6771
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcccgagc agaagaugcc cacgcuccug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcugcucgug gcgcugggca gccgggacga caucguguac      240

gucccggagc ccaugaccua cuggcgcgug cugggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccggcu cgaccagggc gagaucagcg ccggcgacgc ggccgugguc      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgccccgc cgcccgcccu gacgcucauc      480

uucgaccgcc accccaucgc cgcgcugcug ugcuaccccg ccgcccggua ccucaugggg      540

agcaugacgc cccaggccgu ccuggccuuc guggcgcuga ucccgcccac ccuccccggc      600

accaacaucg ugcugggcgc ccugcccgag gaccgccaca ucgaccggcu cgccaagcgc      660

cagcggcccg gggagcgccu ggaccuggcc augcucgccg cgauccggcg cgucuacggc      720

cugcuggcca acaccgugcg guaccuccag ggcgggggcu ccuggcgcga ggacuggggg      780

cagcugagcg gcaccgccgu gcccccgcag ggggccgagc cccaguccaa cgcgggcccc      840

cgcccccaca ucggggacac ccuguucacc cucuuccggg ccccggagcu gcuggccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccuggacg ugcuggcgaa gcgccuccgg      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugccg cgacgcccug     1020

cuccagcuga cguccgggau gguccagacc cacgugacca ccccgggcag cauccccacg     1080

aucugcgacc uggcccggac cuucgcccgc gagauggggg aggcgaacug a              1131


<210>  6772
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6772
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccccgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6773
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6773
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggccagagc agaagaugcc gacucuccuu cgggucuaua ucgaugggcc ccauggaaug      180

gguaaaacga ccacaacuca acuguugguu gcauuaggca gucgcgacga uauuguguac      240

guaccugaac caaugaccua uuggagagug cugggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacaggcu agaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug cccuaugcgg uuacggacgc agugcucgcc      420

ccucauauug ggggagaggc uggcucguca cacgccccac ccccugcacu gacucuuauc      480

uuugaucggc acccaauagc ugcccuguug uguuacccgg cggcccgcua ucucaugggc      540

agcaugacgc cccaagcagu ccuggcuuuc guggcccuga ucccuccaac acuccccggg      600

acuaacauug uauuaggagc ucugccugag gaccgacaua ucgauagacu ugccaagagg      660

cagcggccag gugaacguuu ggaccuggca augcuagccg cuauucgcag aguuuacggc      720

cuccuggcga auaccgugag guaccuucaa gggggaggca guuggcggga ggauuggggu      780

cagcuguccg ggacagcagu gcccccgcag ggagccgaac cucagucuaa cgcuggcccc      840

cgaccacaca ucggcgacac cuuguuuacc cucuuccgcg ccccugagcu guuagcaccc      900

aauggggauc uguauaacgu cuuugccugg gcucucgacg ugcuugccaa aagacugagg      960

ccaaugcaug ucuucauauu ggacuacgau cagagccccg caggaugccg ggacgcgcua     1020

cugcaacuca cuuccgguau gguucagaca cacgugacca cuccuggcuc aauuccaaca     1080

aucugugauc uggcucgcac cuuugccaga gagauggggg aagcaaauug a              1131


<210>  6774
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6774
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacccgagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6775
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6775
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggccggagc agaagaugcc cacgcuccug cgcgucuaua ucgaugggcc ucauggaaug      180

ggcaaaacca caaccacaca acuucugguu gcucucgggu ccagagacga uauuguguac      240

gugcccgaac cuaugaccua uuggcggguc cugggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccgccu ugaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucagauuac aaugggaaug cccuaugccg ugaccgacgc uguccuggcc      420

ccucauaucg gcggcgaggc ggggucuagc cacgccccgc ccccugcucu cacacugauc      480

uuugauagac accccauugc cgcucugcuc uguuacccug ccgcccggua ucugauggga      540

uccaugacgc cccaagcugu gcuugcguuc guugcccuga ucccgccuac ccuccccggc      600

acaaacauug ugcugggggc ccuuccugag gaccgccaua ucgauagacu ggcuaagcgg      660

cagcgccccg gagaaagacu cgaccuggcc augcuggcug ccauucggag agucuacggc      720

cuccuggcga auaccgugcg cuaccuucaa gggggaggca gcuggcggga ggauuggggc      780

cagcugucug ggacagcugu gcccccucag ggagccgaac cgcaguccaa cgccggcccc      840

agaccucaca ucggggacac ccucuuuacc cuguuccgcg cucccgagcu ucuggccccu      900

aauggagauc ucuauaacgu cuuugcuugg gcccuggacg uucuggcgaa acggcucaga      960

cccaugcaug uguucauucu ggacuacgau cagagcccgg ccggcugccg cgacgcccuu     1020

cugcaacuca caucugggau ggugcagacg cacgucacca caccuggauc cauccccacc     1080

aucugugauc uggcucggac auuugcuaga gagaugggcg aagccaauug a              1131


<210>  6776
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAC16235

<400>  6776
auggcaucau auccauguca ccaacacgca agugcauuug aucaagcagc aaggagcaga       60

ggucauucaa auagaagaac agcauuaaga ccuagacgac aacaagaagc uacugaagua      120

agaccagaac aaaaaaugcc aaccuuauua agaguauaua uagauggucc acacggaaug      180

ggaaaaacua caacaacuca auuacuuguu gcauuagguu caagggacga uauaguauau      240

guaccagaac cuaugacaua cuggagagua cuaggugcau cugaaacaau ugcaaauauu      300

uauacaacac aacauagacu agaucaaggc gaaauaucag caggagaugc agcaguuguu      360

augacaagug cacaaauaac uaugggaaug ccauacgcag uuacagacgc aguacucgca      420

ccacauauag gaggagaagc aggaucuuca caugcaccac caccagcacu aacauuaaua      480

uucgacagac aucccauagc agcauuacua ugcuauccag cugcaagaua uuuaauggga      540

ucaaugacac cacaagcagu auuagccuuu guagccuuga uaccaccaac auuaccaggc      600

acaaacauug uucuaggagc auuaccagaa gauagacaua uagauagacu agcaaaaaga      660

caaagaccag gagaaagacu agauuuagcc augcucgcag caauaagaag agucuaugga      720

cuuuuagcaa auacaguaag auacuuacaa ggaggagguu cauggagaga agacugggga      780

caacuaucag gaacagcagu accaccucaa ggagcagaac cacaaucaaa cgcaggaccg      840

agaccccaua uaggagauac auuauucacc uuauuuagag caccagaauu acucgcacca      900

aauggagacc uauauaaugu auuugccugg gcauuagaug uacuagcuaa aagacucaga      960

ccaaugcacg uauuuauacu agauuaugau caauccccag cagguuguag agaugcacuc     1020

uuacaauuaa caucaggaau gguucaaaca cauguaacaa caccaggauc uaucccaaca     1080

auaugugauc uagccagaac auuugcuaga gaaaugggag aagcuaauua a              1131


<210>  6777
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__P06478

<400>  6777

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6778
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6778
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucaugucg ggggggaggc ugggaguuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cgugguggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacug a              1131


<210>  6779
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6779
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacgucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcaggccgu gcuggccuuc guggcgcuca ucccgcccac ccugcccggc      600

accaacaucg uccugggcgc ccuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gggagcggcu ggaccucgcc augcuggccg cgauccgccg gguguacggc      720

cugcucgcca acacggugcg cuaccugcag ggcgggggcu ccugguggga ggacuggggg      780

cagcugagcg gcaccgccgu cccgccccag ggggccgagc cccaguccaa cgcgggcccc      840

cggccccaca ucggggacac ccucuucacc cuguuccgcg cccccgagcu gcucgccccg      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcucgcgaa gcgccugcgg      960

cccaugcacg ucuucauccu ggacuacgac cagagccccg ccggcugccg cgacgcccuc     1020

cugcagcuga cguccgggau ggugcagacc cacgugacca cccccggcag caucccgacg     1080

aucugcgacc ucgcccggac cuucgcccgc gagauggggg aggcgaacug a              1131


<210>  6780
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6780
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacgucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccugguggga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6781
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6781
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccaugucg ggggagaggc uggcucguca cacgccccuc cacccgcacu uacucugauu      480

uuugauaggc acccuaucgc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcaggcagu gcuggcuuuc guagcccuca uacccccuac auuaccaggg      600

acuaacaucg uucugggagc ccuucccgag gaccgccaua uugaucgauu ggccaagaga      660

cagaggccug gugaacggcu ggaccuagca augcucgccg cuauccgucg cguguacggc      720

cugcuugcga auaccgucag auaccugcaa gggggaggca guugguggga ggauuggggu      780

caguuguccg ggacagcagu gccaccccag ggagccgaac cgcagucuaa cgcuggcccu      840

aggccccaca uuggcgacac ccucuuuacg cuguuccggg ccccagaguu acuggcaccu      900

aauggggauc ucuauaacgu guuugccugg gcucuugacg uccuggccaa acgauugcgc      960

cccaugcaug uuuucauccu agacuacgau caaagcccag caggaugcag agacgcgcug     1020

cuccagcuga cuuccgguau ggugcagaca cacguaacca cucccggcuc aauaccuaca     1080

auuugugauc uugcuaggac cuuugcccgg gagauggggg aagcaaauug a              1131


<210>  6782
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6782
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacgugg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcugguggga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6783
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6783
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccaugugg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuaucgc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucaggcugu ucuggcguuc guggcccuca uucccccgac gcugccuggc      600

acaaacaucg uccuuggggc ucugcccgag gaccggcaua uugaucgccu cgccaagaga      660

cagcggccug gagaacgccu ggaccuggcc augcucgcug ccaucagacg gguguacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca gcugguggga ggauuggggc      780

cagcucucug ggacagcugu cccuccccag ggagccgaac cccaguccaa cgccggcccg      840

cgcccccaca uuggggacac ccuguuuacc cuuuuccggg cuccugagcu gcucgccccc      900

aauggagauc uguauaacgu uuuugcuugg gcccuggacg ugcucgcgaa aagacugcgc      960

ccuaugcaug uguucauccu ugacuacgau caaagccccg ccggcugccg ggacgcucug     1020

cuccagcuga caucugggau gguccagacg cacgugacca caccgggauc cauuccuacc     1080

aucugugauc uugccagaac auuugcucgc gagaugggcg aagccaauug a              1131


<210>  6784
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45811

<400>  6784
auggcaucau acccuuguca ccaacaugca ucagcauuug aucaagcagc acgaucaaga       60

ggacauucaa auagaagaac ugcacuaaga ccuagaagac aacaagaagc aacagaagua      120

agauuagaac aaaaaaugcc cacacuacuu agaguuuaua uagauggacc acaugguaug      180

ggaaaaacaa caacaacuca auuacuagua gcauuaggau caagagauga uauaguauau      240

guucccgaac ccaugaccua cuggcaagua uuaggagcaa gcgaaacaau agcaaauaua      300

uacacaacuc aacauagacu ugaccaaggc gaaauaucag caggagacgc agcaguugua      360

augacaucag cacaaauaac aaugggcaug ccauaugcag uuacagacgc aguauuagcu      420

ccccacguag gaggcgaagc aggauccuca caugcaccac caccagcacu aacauuaauu      480

uuugacagac accccauagc ugcacuccua uguuacccag cagcaagaua uuuaaugggc      540

ucaaugacac cacaagcagu auuagccuuc guagcauuga uacccccaac auuaccagga      600

acaaauaucg uuuuaggagc auuaccagaa gacagacaua uagaucgccu ugcaaagaga      660

caaagaccug gagaaagacu agaccuugca augcuagcag caaucagaag aguauacgga      720

uuacuagcaa auacaguaag auaucuucaa ggaggaggau caugguggga agauugggga      780

caauuaucag gaacagcagu uccaccacaa ggagcagaac cucaaucaaa ugcuggcccu      840

agaccacaua uaggagauac auuauuuacu uuauucagag caccugaauu acucgcuccc      900

aauggugauu uauauaaugu uuucgcuugg gcauuagaug uauuagcaaa aagacuaaga      960

ccaaugcaug uauuuauauu agauuaugau caaucaccag caggauguag agaugcuuua     1020

cuacaauuaa caagugguau gguacaaaca cauguaacaa ccccugguuc uauaccaaca     1080

auaugugauu uggcaagaac auuugcaaga gaaaugggcg aagcaaauua a              1131


<210>  6785
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__P08333

<400>  6785

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Ile 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Ile Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6786
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6786
auggcuucgu accccggcca ucagcacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgcccggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aauaggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguacaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gauccagacc cacgucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacug a              1131


<210>  6787
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6787
auggccagcu accccggcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcccgagc agaagaugcc cacgcuccug cgcgucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcugcucgug gcgcugggga gccgggacga caucguguac      240

gucccggagc ccaugaccua cuggcgcgug cugggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccggcu cgaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caucggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcgaggc cgggagcucc cacgccccgc cgcccgcccu gacgcucauc      480

uucgaccgcc accccaucgc cgcgcugcug ugcuaccccg ccgcccggua ccucaugggc      540

agcaugacgc cccaggccgu ccuggccuuc guggcgcuga ucccgcccac ccuccccggc      600

accaacaucg ugcugggggc ccugcccgag gaccgccaca ucgaccggcu cgccaagcgc      660

cagcggcccg gcgagcgccu ggaccuggcc augcucgccg cgauccggcg cgucuacggg      720

cugcuggcca acaccgugcg guaccuccag ggcggcgggu ccuggcgcga ggacuggggc      780

cagcugagcg ggaccgccgu gcccccgcag ggcgccgagc cccaguccaa cgcggggccc      840

cgcccccaca ucggcgacac ccuguucacc cucuuccggg ccccggagcu gcuggccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccuggacg ugcuggcgaa gcgccuccgg      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccgggugccg cgacgcccug     1020

cuccagcuga cguccggcau gauccagacc cacgucacca ccccggggag cauccccacg     1080

aucugcgacc uggcccggac cuucgcccgc gagaugggcg aggcgaacug a              1131


<210>  6788
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6788
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccccgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caucggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gauccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6789
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6789
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggccagagc agaagaugcc gacucuccuu cgggucuaua ucgauggacc ccaugguaug      180

ggcaaaacga ccacaacuca acuguugguu gcauuaggga gucgcgacga uauuguguac      240

guaccugaac caaugaccua uuggagagug cugggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcacaggcu agaccagggc gaaauuuccg ccggugaugc agcugucgug      360

augacaucug cccagaucac cauugggaug cccuaugcgg uuacggacgc agugcucgcc      420

ccucauaucg gaggcgaggc uggcucguca cacgccccac ccccugcacu gacucuuaua      480

uuugaucggc acccaaucgc ugcccuguug ugcuacccgg cggcccgcua ucucaugggg      540

agcaugacgc cccaagcagu ccuggcuuuc guggcccuga uuccuccaac acuccccgga      600

acuaacaucg uauuaggugc ucugccugag gaccgacaua uugauagacu ugccaagagg      660

cagcggccag gcgaacguuu ggaccuggca augcuagccg cuauccgcag aguuuacggg      720

cuccuggcga auaccgugag guaccuucag ggaggcggua guuggcggga ggauuggggg      780

cagcuguccg gaacagcagu gcccccgcaa ggcgccgaac cucagucuaa cgcuggcccc      840

cgaccacaca uaggggacac cuuguuuacc cucuuccgcg ccccugagcu guuagcaccc      900

aauggagauc uguauaacgu cuuugccugg gcucucgacg ugcuugccaa aagacugagg      960

ccaaugcaug ucuucauuuu ggacuacgau cagagccccg cagguugucg ggacgcgcua     1020

cugcaacuca cuuccggcau gauccagaca cacguuacca cuccuggguc aauuccaaca     1080

aucugcgauc uggcucgcac cuuugccaga gagaugggag aagcaaauug a              1131


<210>  6790
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6790
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacccgagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caucggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau gauccagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6791
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6791
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggccggagc agaagaugcc cacgcuccug cgcgucuaua ucgauggacc ucauggcaug      180

gggaaaacca caaccacaca acuucugguu gcucucggau ccagagacga uauuguguac      240

gugcccgaac cuaugaccua uuggcggguc cugggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccgccu ugaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaucggcaug cccuaugccg ugaccgacgc uguccuggcc      420

ccucauaucg gcggggaggc gggaucuagc cacgccccgc ccccugcucu cacacugauu      480

uuugauagac accccaucgc cgcucugcuc ugcuacccug ccgcccggua ucugaugggc      540

uccaugacgc cccaagcugu gcuugcguuc guugcccuga uuccgccuac ccuccccggg      600

acaaacaucg ugcugggagc ccuuccugag gaccgccaua uugauagacu ggcuaagcgg      660

cagcgccccg gcgaaagacu cgaccuggcc augcuggcug ccauccggag agucuacggg      720

cuccuggcga auaccgugcg cuaccuucag ggaggcggca gcuggcggga ggauuggggg      780

cagcugucug gaacagcugu gcccccucaa ggcgccgaac cgcaguccaa cgccgggccc      840

agaccucaca uuggagacac ccucuuuacc cuguuccgcg cucccgagcu ucuggccccu      900

aauggcgauc ucuauaacgu cuuugcuugg gcccuggacg uucuggcgaa acggcucaga      960

cccaugcaug uguucauccu ggacuacgau cagagcccgg ccgggugucg cgacgcccuu     1020

cugcaacuca caucuggaau gauccagacg cacgugacca caccuggcuc cauucccacc     1080

aucugcgauc uggcucggac auuugcuaga gagaugggcg aagccaauug a              1131


<210>  6792
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAA45814

<400>  6792
auggcaucau auccaggaca ucaacaugca ucagcauucg aucaagcagc aagaucaaga       60

ggacauagca aucguagaac agcauuacga ccaagacgac aacaagaagc aacagaagua      120

agaccagaac aaaaaaugcc aacauuacua agaguauaua uagauggucc acauggaaug      180

ggaaaaacaa caacaacuca auuauuagua gcacuaggau caagagauga uauaguuuac      240

guaccagaac caaugacaua uuggagagua cuaggagccu cagaaacuau agcaaauaua      300

uacacaacac aacacagauu agaucaagga gaaauaagug caggugacgc ugcaguuguu      360

augacaagug cacaaauaac uauaggcaug ccuuaugcag uaacugaugc uguccuagca      420

ccacauauag gaggagaagc aggaucauca cacgcuccuc caccugcccu cacauuaaua      480

uuugaucgac accccauagc ugcacuauua uguuauccag cagcaagaua ucucauggga      540

uccaugacac cacaagcugu uuuagccuuu guagcauuaa uuccaccaac ucucccaggc      600

acaaauauug uauuaggagc ccuaccagaa gaucgacaua uagauagauu agcaaaaaga      660

caaagaccag gagaaagauu agauuuagcu augcuagcug cuauacgucg aguauaugga      720

uuacuagcaa auacaguaag auauuuacaa ggaggaggaa guuggagaga agacugggga      780

caauuaucag gaacagcugu accaccacaa ggagcagaac cacaaucaaa ugcaggacca      840

agaccacaca uaggugauac acuauuuacc uuauucagag caccagaacu auuagcucca      900

aauggagacc uauauaacgu auuugcaugg gccuuagacg uauuagcuaa aagacuaaga      960

ccaaugcaug uuuuuauucu cgacuaugau caaucaccag ccgguuguag agacgcauua     1020

cuacaauuaa cuucagguau gauacaaaca cauguaacaa caccuggauc aauaccaacc     1080

auaugcgacc uagcaaggac auuugcaaga gaaaugggag aagcaaauua a              1131


<210>  6793
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9DLP2

<400>  6793

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Gly Val Gly Glu Ala Asn 
    370                 375     


<210>  6794
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6794
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca cccccggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg ggaguggggg aggcuaacug a              1131


<210>  6795
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6795
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccggagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcaggccgu ccuggccuuc guggcgcuca ucccgcccac ccugcccggc      600

accaacaucg ugcugggcgc ccuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gggagcggcu ggaccucgcc augcuggccg cgauccgccg ggucuacggc      720

cugcucgcca acacggugcg cuaccugcag ggcgggggcu ccuggcggga ggacuggggg      780

cagcugagcg gcaccgccgu gccgccccag ggggccgagc cccaguccaa cgcgggcccc      840

cgcccccaca ucggggacac ccucuucacc cuguuccgcg cccccgagcu gcucgccccg      900

aacggcgacc uguacaacgu cuucgccugg gcccuggacg ugcucgcgaa gcggcugcgc      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugccg ggacgcccuc     1020

cugcagcuga cguccgggau gguccagacc cacgugacca cccccggcag caucccgacg     1080

aucugcgacc ucgcccgcac cuucgcccgc ggggugggcg aggcgaacug a              1131


<210>  6796
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6796
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc ggcgucggcg aggccaacug a              1131


<210>  6797
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6797
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc acccuauagc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcaggcagu ccuggcuuuc guggcccuca uucccccuac auuaccaggg      600

acuaacaucg uacugggagc ccuucccgag gaccgccaua ucgaucgauu ggccaagaga      660

cagaggccug gugaacggcu ggaccuagca augcucgccg cuauucgucg cguuuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca guuggaggga ggauuggggu      780

caguuguccg ggacagcagu cccaccccag ggagccgaac cgcagucuaa cgcuggcccu      840

cggccccaca ucggcgacac ccucuuuacg cuguuccgag ccccagaguu acuggcaccu      900

aauggggauc ucuauaacgu guuugccugg gcucuugacg ugcuggccaa acgcuugaga      960

cccaugcaug ucuucauacu agacuacgau caaagcccag caggaugcag ggacgcgcug     1020

cuccagcuga cuuccgguau gguucagaca cacgugacca cucccggcuc aauuccuaca     1080

aucugugauc uugcucggac cuuugcccgc gggguaggag aggcaaauug a              1131


<210>  6798
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6798
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga ggcgugggcg aggccaacug a              1131


<210>  6799
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6799
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuauugc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucaggcugu gcuggcguuc guugcccuca uucccccgac gcugccuggc      600

acaaacaucg ugcuuggggc ucugcccgag gaccggcaua ucgaucgccu cgccaagaga      660

cagcggccug gagaacgccu ggaccuggcc augcucgcug ccauuagacg ggucuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca gcuggcgcga ggauuggggc      780

cagcucucug ggacagcugu gccuccccag ggagccgaac cccaguccaa cgccggcccg      840

cggccccaca ucggggacac ccuguuuacc cuuuucagag cuccugagcu gcucgccccc      900

aauggagauc uguauaacgu cuuugcuugg gcccuggacg uucucgcgaa acgccugcgg      960

ccuaugcaug uguucauucu ugacuacgau caaagccccg ccggcugcag agacgcucug     1020

cuccagcuga caucugggau ggugcagacg cacgucacca caccgggauc caucccuacc     1080

aucugugauc uugcccgcac auuugcucgg ggcgugggcg aggccaauug a              1131


<210>  6800
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAG40842

<400>  6800
auggcuucau auccauguca ucaacacgca ucagcauucg aucaagccgc aagaucaaga       60

ggucauucaa auagaagaac agcacuaaga ccaagaagac aacaagaagc aacugaagua      120

agacuagaac aaaaaaugcc aacuuuacua agaguuuaua uugauggccc acauggcaug      180

ggaaaaacaa cuacaacaca acuccuagua gcauuaggcu cacgagauga uauaguauac      240

gucccagaac caaugacaua uuggcaagua uuaggagcau cagaaacaau agcuaauaua      300

uauacaacac aacauagacu cgaucaaggu gaaauaucag caggugaugc agcaguagua      360

augacaucag cacaaauaac aaugggaaug ccauacgcag uaacagacgc aguacuagca      420

ccccacauag gaggugaagc cgguucauca caugcaccac caccugcacu aacacuaaua      480

uuugaucgac aucccauagc ugcauuauua uguuacccug cagcaagaua ucuaauggga      540

ucaaugacac cacaagcagu auuagcauuu gucgcacuaa uaccaccaac uuuaccagga      600

acaaauauag uauuaggagc acuaccagaa gacaggcaua uagauagacu agcaaaaaga      660

caaagaccag gagaacgcuu agaucuagca augcuagcag caauuaggag aguauaugga      720

uuauuagcaa auacaguuag auauuuacaa ggcgguggau cauggagaga ggauugggga      780

caauuaucag guacugcagu accaccucaa ggagcagaac cacaaucaaa cgccggaccg      840

agaccacaua uaggugauac auuauucaca uuauuuagag ccccagaacu acuagcacca      900

aauggugauu uauauaacgu auucgcaugg gccuuagaug uacuagcaaa aagguuaaga      960

cccaugcaug uuuucauauu agauuaugau caaaguccag caggauguag agaugcucua     1020

cuacaauuaa caaguggaau gguucaaacu cauguaacaa caccaggauc cauaccaaca     1080

auaugugauu uagcaagaac uuucgcaaga ggaguaggug aagcaaauua a              1131


<210>  6801
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS0

<400>  6801

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro 
        275                 280 


<210>  6802
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6802
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

uga                                                                    843


<210>  6803
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6803
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcaggccgu ccuggccuuc guggcgcuca ucccgcccac ccugcccggc      600

accaacaucg ugcugggcgc ccuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gggagcggcu ggaccucgcc augcuggccg cgauccgccg ggucuacggc      720

cugcucgcca acacggugcg cuaccugcag ggcgggggcu ccuggcggga ggacuggggg      780

cagcugagcg gcaccgccgu gccgccccag ggggccgagc cccaguccaa cgcgggcccc      840

uga                                                                    843


<210>  6804
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6804
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

uga                                                                    843


<210>  6805
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6805
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc acccuauagc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcaggcagu ccuggcuuuc guggcccuca uucccccuac auuaccaggg      600

acuaacaucg uacugggagc ccuucccgag gaccgccaua ucgaucgauu ggccaagaga      660

cagaggccug gugaacggcu ggaccuagca augcucgccg cuauucgucg cguuuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca guuggaggga ggauuggggu      780

caguuguccg ggacagcagu cccaccccag ggagccgaac cgcagucuaa cgcuggcccu      840

uga                                                                    843


<210>  6806
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6806
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

uga                                                                    843


<210>  6807
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6807
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuauugc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucaggcugu gcuggcguuc guugcccuca uucccccgac gcugccuggc      600

acaaacaucg ugcuuggggc ucugcccgag gaccggcaua ucgaucgccu cgccaagaga      660

cagcggccug gagaacgccu ggaccuggcc augcucgcug ccauuagacg ggucuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca gcuggcgcga ggauuggggc      780

cagcucucug ggacagcugu gccuccccag ggagccgaac cccaguccaa cgccggcccg      840

uga                                                                    843


<210>  6808
<211>  843
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AEL30083

<400>  6808
auggcaucau auccaugcca ucaacaugca agcgcauuug aucaagcagc aagaucaaga       60

ggacauagca auagaagaac ugcauuaaga ccaagaagac aacaagaagc aacagaagua      120

agauuagaac aaaaaaugcc aacacuacua agaguauaua uagauggacc acacggcaug      180

ggaaaaacca caacuacaca acuauuagua gcucuaggaa gcagagauga uauaguauau      240

guuccagaac caaugacaua uuggcaagua cucggagcau cagaaacaau agcaaauaua      300

uacacaacac aacauagacu ugaucaagga gaaauaagcg caggugaugc agcuguuguu      360

augacaagcg cacaaauaac aaugggaaug ccauaugcag uaaccgaugc aguauuagca      420

ccucacauag gaggagaagc aggaaguagc caugcaccac caccagcauu aacacuaaua      480

uuugaccgac acccaauagc agcauuacua uguuauccag cagcaagaua ucuaauggga      540

aguaugacac cacaagcagu acuagcauuu guagcauuaa uacccccaac auuaccagga      600

acaaauauag uauuaggagc acuaccagaa gauagacaua uagauagauu agcaaaaaga      660

caaagaccag gagaaagauu agauuuagca auguuagcag caauaaggag aguauaugga      720

uuauuagcaa auacaguaag auauuuacaa ggaggaggau cauggagaga agacugggga      780

caauuaucag gaacagcagu accaccacaa ggagcagaac cucaaucaaa ugcaggacca      840

uaa                                                                    843


<210>  6809
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS1

<400>  6809

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp 
            100                 105             


<210>  6810
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6810
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgacuag                                          327


<210>  6811
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6811
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcguguaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggacuga                                          327


<210>  6812
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6812
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgacuga                                          327


<210>  6813
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6813
auggccagcu accccugcca ccagcaugcu uccgcauucg accaggccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgacuga                                          327


<210>  6814
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6814
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggacuga                                          327


<210>  6815
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6815
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggacuga                                          327


<210>  6816
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11946

<400>  6816
auggcaucau acccaugcca ccaacacgca ucagcauucg accaagcagc aagaucaaga       60

ggacacucaa acagaagaac agcacuaaga ccaagaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacacuacua agaguauaca uagacggacc acacggaaug      180

ggaaaaacaa caacaacaca acuacuagua gcacuaggau caagagacga cauaguauac      240

guaccagaac caaugacaua cuggcaagua cuaggagcau cagaaacaau agcaaacaua      300

uacacaacac aacacagacu agacuaa                                          327


<210>  6817
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS2

<400>  6817

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr 
            100             


<210>  6818
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6818
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacau aa                                                          312


<210>  6819
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6819
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcguguaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgu ga                                                          312


<210>  6820
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6820
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccu ga                                                          312


<210>  6821
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6821
auggccagcu accccugcca ccagcaugcu uccgcauucg accaggccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuu ga                                                          312


<210>  6822
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6822
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccu ga                                                          312


<210>  6823
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6823
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgu ga                                                          312


<210>  6824
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11945

<400>  6824
auggcaucau acccaugcca ccaacacgca ucagcauucg accaagcagc aagaucaaga       60

ggacacucaa acagaagaac agcacuaaga ccaagaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacacuacua agaguauaca uagacggacc acacggaaug      180

ggaaaaacaa caacaacaca acuacuagua gcacuaggau caagagacga cauaguauac      240

guaccagaac caaugacaua cuggcaagua cuaggagcau cagaaacaau agcaaacaua      300

uacacaacau aa                                                          312


<210>  6825
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS3

<400>  6825

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Ala His Asp Pro Ile Ser Gly Thr Arg Tyr Leu 
    130                 135                 140                 


Pro Cys Phe Gly Pro Pro Ser Cys Trp Pro Pro Thr Ala Thr Cys Ile 
145                 150                 155                 160 


Thr Cys Leu Pro Gly Pro Trp Thr Ser Trp Pro Asn Ala Ser Val Pro 
                165                 170                 175     


Cys Thr Ser Leu Ser Trp Ile Thr Thr Asn Arg Pro Pro Ala Ala Gly 
            180                 185                 190         


Thr Pro Cys Cys Asn Leu Pro Pro Gly Trp Ser Arg Pro Thr Ser Pro 
        195                 200                 205             


Pro Gln Ala Pro Tyr Arg Arg Ser Ala Thr Trp Arg Ala Arg Leu Pro 
    210                 215                 220                 


Gly Arg Trp Gly Arg Leu Thr Glu Thr Arg Lys Glu Thr Ile Pro Glu 
225                 230                 235                 240 


Gly Thr Arg Ala Met Thr Ala Ile Lys Arg Gln Asn Lys Thr His Gly 
                245                 250                 255     


Cys Trp Val Val Cys Ser 
            260         


<210>  6826
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6826
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg cccacgaccc cauaucgggg      420

acacguuauu uacccuguuu cgggcccccg aguugcuggc ccccaacggc gaccuguaua      480

acguguuugc cugggccuug gacgucuugg ccaaacgccu ccgucccaug cacgucuuua      540

uccuggauua cgaccaaucg cccgccggcu gccgggacgc ccugcugcaa cuuaccuccg      600

ggauggucca gacccacguc accaccccag gcuccauacc gacgaucugc gaccuggcgc      660

gcacguuugc ccgggagaug ggggaggcua acugaaacac ggaaggagac aauaccggaa      720

ggaacccgcg cuaugacggc aauaaaaaga cagaauaaaa cgcacgggug uugggucguu      780

uguucauaa                                                              789


<210>  6827
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6827
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg cccacgaccc caucagcggc      420

acccgguacc ugcccugcuu cgggccgccc uccugcuggc cgcccacggc gaccugcauc      480

acgugccucc ccggccccug gaccagcugg cccaacgccu ccgugcccug caccagccug      540

uccuggauca ccaccaaccg cccgcccgcc gccgggaccc ccugcugcaa ccugcccccg      600

ggcuggagcc ggcccacguc cccgccccag gcccccuacc gccggagcgc gaccuggcgc      660

gcccggcucc ccggccgcug ggggcggcug accgagaccc gcaaggagac gauccccgag      720

ggcacccggg ccaugaccgc caucaagcgc cagaacaaga cccacgggug cugggugguc      780

ugcuccuga                                                              789


<210>  6828
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6828
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg cccacgaccc caucuccggc      420

acccgcuacc uccccugcuu cggccccccc uccugcuggc cccccaccgc caccugcauc      480

accugccucc ccggccccug gaccuccugg cccaacgccu ccguccccug caccucccuc      540

uccuggauca ccaccaaccg cccccccgcc gccggcaccc ccugcugcaa ccuccccccc      600

ggcugguccc gccccaccuc ccccccccag gcccccuacc gccgcuccgc caccuggcgc      660

gcccgccucc ccggccgcug gggccgccuc accgagaccc gcaaggagac cauccccgag      720

ggcacccgcg ccaugaccgc caucaagcgc cagaacaaga cccacggcug cugggucguc      780

ugcuccuga                                                              789


<210>  6829
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6829
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg cacaugaccc cauuucgggg      420

acgagguacc ugccuuguuu uggaccaccc ucaugcuggc cuccaacugc caccuguauc      480

acaugccuuc cgggccccug gacuagcugg ccuaacgcua guguuccaug uaccucccug      540

ucuuggauaa caaccaaucg gcccccugcc gcaggcacgc caugcuguaa cuugcccccg      600

ggguggagcc gcccuacuuc acccccacag gcuccuuauc gaagauccgc cacauggagg      660

gcgcggcucc ccggacguug gggucgccug accgagacua gaaaggagac aaucccagaa      720

ggcaccaggg ccaugacggc aauuaaacgg cagaauaaga cccacgggug cugggugguc      780

uguaguuga                                                              789


<210>  6830
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6830
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg cccacgaccc caucagcggc      420

accagauacc ugcccugcuu cggccccccc agcugcuggc cccccaccgc caccugcauc      480

accugccugc ccggccccug gaccagcugg cccaacgcca gcgugcccug caccagccug      540

agcuggauca ccaccaacag accccccgcc gccggcaccc ccugcugcaa ccugcccccc      600

ggcuggagca gacccaccag ccccccccag gcccccuaca gaagaagcgc caccuggaga      660

gccagacugc ccggcagaug gggcagacug accgagacca gaaaggagac cauccccgag      720

ggcaccagag ccaugaccgc caucaagaga cagaacaaga cccacggcug cuggguggug      780

ugcagcuga                                                              789


<210>  6831
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6831
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg cucaugaccc caucucuggc      420

acccgcuacc ucccuuguuu uggcccgccc agcugcuggc cucccacagc caccuguauc      480

acgugccugc cugggcccug gacauccugg ccgaacgcga gcgugccuug uaccucucug      540

uccuggauua caaccaauag acccccugcc gcuggaaccc ccugcuguaa ccugcccccu      600

ggcuggagcc ggccgacauc ucccccucag gcccccuauc gcagauccgc uacguggcgg      660

gcccgccucc cugggagaug gggacggcuu accgagacaa gaaaggagac cauccccgaa      720

ggcacacgcg ccaugaccgc uauuaaacgg cagaauaaga cgcacgggug cugggucgug      780

uguagcuga                                                              789


<210>  6832
<211>  789
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11944

<400>  6832
auggcauccu acccuugcca ucaacaugcc ucagcauuug accaagcagc uagaucaaga       60

ggacacucaa acagaagaac agcauuaaga ccaagacgac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacacuacua agaguauaua uagauggacc acauggaaug      180

ggaaaaacaa caacaacaca acucuuagua gcacuaggau caagagacga uauaguauac      240

guaccagaac caaugacaua uuggcaagua uuaggagcau cagaaacaau agcaaacaua      300

uauacaacac aacaucgauu agaucaagga gaaauaucag caggagacgc agcaguggua      360

augacaucag cacaaaucac uaugggaaug ccauacgcag cacaugaccc cauauccgga      420

acaagauauc uaccaugcuu cggaccacca ucaugcuggc caccaacagc aacauguaua      480

acaugcuuac caggaccaug gacaucaugg ccuaacgccu caguaccaug uaccucauua      540

ucauggauua caacaaacag accaccagca gcaggaacac cauguugcaa ucuaccacca      600

ggauggucua gaccaacauc accaccacaa gcaccuuaua gaagaucagc aacauggaga      660

gcaagacuuc cagguagaug gggacgcuua accgaaacca gaaaagaaac aauaccagaa      720

ggaacaagag cuaugacagc aauaaaacga caaaacaaaa cacauggaug cuggguagua      780

uguucauaa                                                              789


<210>  6833
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS4

<400>  6833

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Arg Pro Cys Trp Arg Ser Trp Pro 
            180                 185                 190         


Ser Ser Arg Arg Pro Cys Pro Ala Gln Thr Ser Cys Trp Gly Pro Phe 
        195                 200                 205             


Arg Arg Thr Asp Thr Ser Thr Ala Trp Pro Asn Ala Ser Ala Pro Ala 
    210                 215                 220                 


Ser Gly Leu Thr Trp Leu Cys Trp Pro Arg Phe Ala Ala Phe Thr Gly 
225                 230                 235                 240 


Cys Leu Pro Ile Arg Cys Gly Ile Cys Arg Ala Ala Gly Arg Gly Gly 
                245                 250                 255     


Arg Ile Gly Asp Ser Phe Arg Gly Arg Pro Cys Arg Pro Arg Val Pro 
            260                 265                 270         


Ser Pro Arg Ala Thr Arg Ala His Asp Pro Ile Ser Gly Thr Arg Tyr 
        275                 280                 285             


Leu Pro Cys Phe Gly Pro Pro Ser Cys Trp Pro Pro Thr Ala Thr Cys 
    290                 295                 300                 


Ile Thr Cys Leu Pro Gly Pro Trp Thr Ser Trp Pro Asn Ala Ser Val 
305                 310                 315                 320 


Pro Cys Thr Ser Leu Ser Trp Ile Thr Thr Asn Arg Pro Pro Ala Ala 
                325                 330                 335     


Gly Thr Pro Cys Cys Asn Leu Pro Pro Gly Trp Ser Arg Pro Thr Ser 
            340                 345                 350         


Pro Pro Gln Ala Pro Tyr Arg Arg Ser Ala Thr Trp Arg Ala Arg Leu 
        355                 360                 365             


Pro Gly Arg Trp Gly Arg Leu Thr Glu Thr Arg Lys Glu Thr Ile Pro 
    370                 375                 380                 


Glu Gly Thr Arg Ala Met Thr Ala Ile Lys Arg Gln Asn Lys Thr His 
385                 390                 395                 400 


Gly Cys Trp Val Val Cys Ser 
                405         


<210>  6834
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6834
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc ccaggccgug cuggcguucg uggcccucau cccgccgacc uugcccggca      600

caaacaucgu guugggggcc cuuccggagg acagacacau cgaccgccug gccaaacgcc      660

agcgccccgg cgagcggcuu gaccuggcua ugcuggccgc gauucgccgc guuuacgggc      720

ugcuugccaa uacggugcgg uaucugcagg gcggcggguc guggcgggag gauuggggac      780

agcuuucggg gacggccgug ccgccccagg gugccgagcc ccagagcaac gcgggcccac      840

gaccccauau cggggacacg uuauuuaccc uguuucgggc ccccgaguug cuggccccca      900

acggcgaccu guauaacgug uuugccuggg ccuuggacgu cuuggccaaa cgccuccguc      960

ccaugcacgu cuuuauccug gauuacgacc aaucgcccgc cggcugccgg gacgcccugc     1020

ugcaacuuac cuccgggaug guccagaccc acgucaccac cccaggcucc auaccgacga     1080

ucugcgaccu ggcgcgcacg uuugcccggg agauggggga ggcuaacuga aacacggaag     1140

gagacaauac cggaaggaac ccgcgcuaug acggcaauaa aaagacagaa uaaaacgcac     1200

ggguguuggg ucguuuguuc auaa                                            1224


<210>  6835
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6835
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccccggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcggcccug cuggcgcucc uggcccagcu cccggcgccc cugcccggcc      600

cagaccagcu gcuggggccc cuuccggcgc accgacacgu ccaccgccug gcccaacgcg      660

agcgcccccg ccuccggccu gaccuggcuc ugcuggccgc gguucgccgc cuucaccggg      720

ugccugccca uccgcugcgg caucugccgg gcggccgggc gcggcggccg caucggggac      780

agcuuccggg gccgccccug ccggccccgc gucccgagcc cccgggccac gcgcgcccac      840

gaccccaucu ccgggacccg guaccugccc ugcuucggcc cgcccagcug cuggcccccg      900

accgcgaccu gcaucacgug ccuccccggg cccuggaccu ccuggcccaa cgccagcgug      960

ccgugcaccu cccugagcug gaucaccacg aaccgcccgc ccgccgccgg cacccccugc     1020

ugcaaccugc cgcccggcug gucccggccc accagcccgc cccaggcccc cuaccgccgg     1080

uccgcgaccu ggcgcgcccg gcuccccggg cgcuggggcc ggcugacgga gacccgcaag     1140

gagaccaucc ccgaggggac ccgggccaug acggccauca agcgccagaa caagacccac     1200

ggcugcuggg uggucugcag cuga                                            1224


<210>  6836
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6836
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccgccccug cuggcgcucc uggcccuccu cccgccgccc cugccccgcc      600

cagaccuccu gcuggggccc cuuccgccgc accgacaccu ccaccgccug gcccaacgcc      660

uccgcccccg ccuccggccu caccuggcuc ugcuggcccc gcuucgccgc cuucaccggc      720

ugccucccca uccgcugcgg caucugccgc gccgccggcc gcggcggccg caucggcgac      780

uccuuccgcg gccgccccug ccgcccccgc guccccuccc cccgcgccac ccgcgcccac      840

gaccccaucu ccggcacccg cuaccucccc ugcuucggcc cccccuccug cuggcccccc      900

accgccaccu gcaucaccug ccuccccggc cccuggaccu ccuggcccaa cgccuccguc      960

cccugcaccu cccucuccug gaucaccacc aaccgccccc ccgccgccgg cacccccugc     1020

ugcaaccucc cccccggcug gucccgcccc accucccccc cccaggcccc cuaccgccgc     1080

uccgccaccu ggcgcgcccg ccuccccggc cgcuggggcc gccucaccga gacccgcaag     1140

gagaccaucc ccgagggcac ccgcgccaug accgccauca agcgccagaa caagacccac     1200

ggcugcuggg ucgucugcuc cuga                                            1224


<210>  6837
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6837
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaggc cggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc acccuauagc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcgccccug cuggcgaagu uggccuuccu cuagaaggcc augucccgca      600

cagacaagcu gcugggggcc uuuccggcgu acugacaccu ccacagcuug gccaaacgcc      660

ucagcucccg ccaguggacu gaccuggcuc uguuggccgc gcuuugcagc cuucacgggu      720

ugcuuaccua ucagaugugg cauuugcagg gcugcggggc ggggaggccg aaucggugau      780

agcuuucgcg ggagacccug uaggccacgg gucccuucuc cccgcgcaac uagagcccau      840

gacccaauuu ccggaacaag guaccugccc ugcuucggcc cuccaucaug uuggccgccc      900

accgcuacuu gcaucacaug ccuuccuggc ccauggacca gcuggcccaa ugccagugug      960

ccuuguacgu cuuuguccug gauaaccaca aaccguccac ccgcagccgg gacuccgugc     1020

uguaaucugc cuccaggaug gagccggccc accucgccuc cccaggcucc auaccgaaga     1080

ucugccacau ggagggcacg ccuaccuggu cgguggggca gacucacuga gaccaggaag     1140

gaaacaauuc ccgaggggac ccgcgcgaug acugcuauca aacgacagaa caagacgcac     1200

ggaugcuggg uaguuuguuc cuga                                            1224


<210>  6838
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6838
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc ccagacccug cuggagaagc uggcccagca gcagaagacc cugccccgcc      600

cagaccagcu gcuggggccc cuucagaaga accgacacca gcaccgccug gcccaacgcc      660

agcgcccccg ccagcggccu gaccuggcug ugcuggccca gauucgccgc cuucaccggc      720

ugccugccca ucagaugcgg caucugcaga gccgccggca gaggcggcag aaucggcgac      780

agcuucagag gcagacccug cagacccaga gugcccagcc ccagagccac cagagcccac      840

gaccccauca gcggcaccag auaccugccc ugcuucggcc cccccagcug cuggcccccc      900

accgccaccu gcaucaccug ccugcccggc cccuggacca gcuggcccaa cgccagcgug      960

cccugcacca gccugagcug gaucaccacc aacagacccc ccgccgccgg cacccccugc     1020

ugcaaccugc cccccggcug gagcagaccc accagccccc cccaggcccc cuacagaaga     1080

agcgccaccu ggagagccag acugcccggc agauggggca gacugaccga gaccagaaag     1140

gagaccaucc ccgagggcac cagagccaug accgccauca agagacagaa caagacccac     1200

ggcugcuggg uggugugcag cuga                                            1224


<210>  6839
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6839
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuauugc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucggcccug cuggcgcagc uggccgucuu ccagacggcc uugucccgcu      600

cagacgagcu gcuggggccc uuuccgcaga acagacaccu cuacagcgug gcccaacgcc      660

uccgcucccg ccagcgggcu gaccuggcuc uguuggccuc gguuugccgc uuucaccgga      720

ugccugccga ucagaugugg cauuugccgc gccgcggggc ggggaggcag aaucggcgau      780

ucuuuucgcg ggcggcccug uagaccucgc gugcccuccc cucgggcuac aagagcccau      840

gaccccauua gcggaacgcg cuaccuuccg ugcuucggcc cucccuccug uuggccuccc      900

accgccacau gcauuaccug ccugccuggg cccuggacau cuuggccgaa ugcuagcguu      960

ccuuguaccu cccucagcug gaucacgaca aaccggccuc ccgccgcugg aacccccugc     1020

uguaaucugc cgcccggcug gucuagaccu accuccccuc cccaggcccc cuaccgccgg     1080

agcgcgacau ggagagcccg gcugccuggg cgcuggggaa gacucaccga gacacggaag     1140

gaaacgaucc ccgagggcac cagagcuaug acagccauca aacgccagaa caagacccac     1200

ggcugcuggg uggucuguuc uuga                                            1224


<210>  6840
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11943

<400>  6840
auggcaaguu auccauguca ucaacaugca ucagcauuug aucaagcagc aagaagcagg       60

ggacauucaa auagaagaac ugcucuuaga cccaggagac aacaagaagc aacagaaguu      120

agauuagaac aaaaaaugcc uacauuauua cgaguauaca uagacggacc acauggaaug      180

ggaaaaacaa caacaacgca auuacuagua gcuuuaggau caagagauga cauaguauac      240

guuccggaac caaugacaua uuggcaagua cuuggagcaa gugaaacaau agcaaacaua      300

uauacuaccc aacaucgauu agaucaagga gaaauaagcg caggagaugc ugcuguagua      360

augacaucag cacaaauaac aauggggaug ccauaugcag uuaccgaugc aguauuagca      420

ccucauauag gcggagaagc aggaaguagu caugcaccac caccagcacu uacuuuaaua      480

uuugauaggc auccuauagc agcauuauua uguuaucccg cagcaagaua uuuaauggga      540

agcaugacac caagaccaug uuggagauca uggccgucau caagaagacc auguccugca      600

caaacaucau guuggggacc auuuagaaga acagacacua guacagcuug gccaaaugca      660

agugcuccag caucaggacu aacauggcuc uguuggccaa gauuugcagc auucacagga      720

uguuugccaa uaagaugcgg aauauguaga gcagcaggac gaggaggaag aauaggugau      780

ucauucagag gaagaccuug uagaccaaga guaccuaguc caagagcaac uagagcccau      840

gauccaauua gcggaacaag auauuuacca uguuuuggac caccuaguug uuggccacca      900

acagcaacau guauaacuug uuuaccagga ccguggacau cauggccuaa cgcaagugua      960

ccauguaccu cacuaucaug gauaacaaca aauagaccac cagccgcagg uacaccuugc     1020

ugcaauuuac ccccuggaug gucaagacca acuuccccac cucaagcacc auacagaagg     1080

uccgcaacau ggcgugcaag auuaccagga agauggggaa gacucacaga aacaagaaaa     1140

gaaacaauac cagaaggaac uagagcuaug acugcaauaa aaagacaaaa uaaaacacau     1200

ggaugcuggg uaguauguuc auaa                                            1224


<210>  6841
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9ENS5

<400>  6841

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Gln Ala Pro Tyr Arg Arg Ser Ala Thr Trp Arg Ala Arg Leu 
        355                 360                 365             


Pro Gly Arg Trp Gly Arg Leu Thr Glu Thr Arg Lys Glu Thr Ile Pro 
    370                 375                 380                 


Glu Gly Thr Arg Ala Met Thr Ala Ile Lys Arg Gln Asn Lys Thr His 
385                 390                 395                 400 


Gly Cys Trp Val Val Cys Ser 
                405         


<210>  6842
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6842
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca cccaggcucc auaccgacga     1080

ucugcgaccu ggcgcgcacg uuugcccggg agauggggga ggcuaacuga aacacggaag     1140

gagacaauac cggaaggaac ccgcgcuaug acggcaauaa aaagacagaa uaaaacgcac     1200

ggguguuggg ucguuuguuc auaa                                            1224


<210>  6843
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6843
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcaggccgu ccuggccuuc guggcgcuca ucccgcccac ccugcccggc      600

accaacaucg ugcugggcgc ccuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gggagcggcu ggaccucgcc augcuggccg cgauccgccg ggucuacggc      720

cugcucgcca acacggugcg cuaccugcag ggcgggggcu ccuggcggga ggacuggggg      780

cagcugagcg gcaccgccgu gccgccccag ggggccgagc cccaguccaa cgcgggcccc      840

cgcccccaca ucggggacac ccucuucacc cuguuccgcg cccccgagcu gcucgccccg      900

aacggcgacc uguacaacgu cuucgccugg gcccuggacg ugcucgcgaa gcggcugcgc      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugccg ggacgcccuc     1020

cugcagcuga cguccgggau gguccagacc cacgugacca cccaggcccc cuaccgccgg     1080

agcgccacgu ggcgcgcgcg gcucccgggc cgcugggggc ggcugaccga gacccgcaag     1140

gagaccaucc ccgagggcac gcgggccaug accgccauca agcgccagaa caagacccac     1200

gggugcuggg uggucugcuc cuga                                            1224


<210>  6844
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6844
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccaggcccc cuaccgccgc     1080

uccgccaccu ggcgcgcccg ccuccccggc cgcuggggcc gccucaccga gacccgcaag     1140

gagaccaucc ccgagggcac ccgcgccaug accgccauca agcgccagaa caagacccac     1200

ggcugcuggg ucgucugcuc cuga                                            1224


<210>  6845
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6845
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc acccuauagc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcaggcagu ccuggcuuuc guggcccuca uucccccuac auuaccaggg      600

acuaacaucg uacugggagc ccuucccgag gaccgccaua ucgaucgauu ggccaagaga      660

cagaggccug gugaacggcu ggaccuagca augcucgccg cuauucgucg cguuuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca guuggaggga ggauuggggu      780

caguuguccg ggacagcagu cccaccccag ggagccgaac cgcagucuaa cgcuggcccu      840

cggccccaca ucggcgacac ccucuuuacg cuguuccgag ccccagaguu acuggcaccu      900

aauggggauc ucuauaacgu guuugccugg gcucuugacg ugcuggccaa acgcuugaga      960

cccaugcaug ucuucauacu agacuacgau caaagcccag caggaugcag ggacgcgcug     1020

cuccagcuga cuuccgguau gguucagaca cacgugacca cucaggcucc cuaucggcgc     1080

ucagccacau ggagagcaag gcuuccuggc cguugggggc ggcugaccga gacgcgaaag     1140

gaaaccauuc cagagggaac aagagccaug acugcuauca aaaggcaaaa uaagacccac     1200

ggcuguuggg uagugugcag uuga                                            1224


<210>  6846
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6846
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccaggcccc cuacagaaga     1080

agcgccaccu ggagagccag acugcccggc agauggggca gacugaccga gaccagaaag     1140

gagaccaucc ccgagggcac cagagccaug accgccauca agagacagaa caagacccac     1200

ggcugcuggg uggugugcag cuga                                            1224


<210>  6847
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6847
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuauugc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucaggcugu gcuggcguuc guugcccuca uucccccgac gcugccuggc      600

acaaacaucg ugcuuggggc ucugcccgag gaccggcaua ucgaucgccu cgccaagaga      660

cagcggccug gagaacgccu ggaccuggcc augcucgcug ccauuagacg ggucuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca gcuggcgcga ggauuggggc      780

cagcucucug ggacagcugu gccuccccag ggagccgaac cccaguccaa cgccggcccg      840

cggccccaca ucggggacac ccuguuuacc cuuuucagag cuccugagcu gcucgccccc      900

aauggagauc uguauaacgu cuuugcuugg gcccuggacg uucucgcgaa acgccugcgg      960

ccuaugcaug uguucauucu ugacuacgau caaagccccg ccggcugcag agacgcucug     1020

cuccagcuga caucugggau ggugcagacg cacgucacca cacaggcccc guaucgccgg     1080

uccgcuaccu ggagagcccg ccuuccugga cgguggggca gacugacaga gacccgcaag     1140

gaaacgaucc ccgagggcac acgggcgaug accgccauca aaagacaaaa uaagacccac     1200

ggguguuggg ugguuugcag cuga                                            1224


<210>  6848
<211>  1224
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__BAB11942

<400>  6848
auggcaaguu auccuugcca ucaacacgca agugcauuug accaagcagc acgaaguaga       60

ggucacagua auagacgaac agcacuuaga ccacgaagac aacaagaagc cacagaagua      120

cgauuagaac aaaaaaugcc cacacuauua agaguauaca uagauggucc ucauggaaug      180

ggcaaaacaa caacuacaca auuauuagua gcauuaggaa guagagauga uauaguauau      240

guuccggaac caaugacaua uuggcaagua uuaggagccu cagaaacgau agcaaacaua      300

uacacuacac aacauaggcu agaucaagga gaaauaagug cuggagaugc agcagucgua      360

augacaucag cccaaauaac aaugggaaug ccauaugcag uaacagaugc cguauuagcu      420

ccacauauag gaggagaagc aggaucauca caugcuccac ccccagcucu aacucucaua      480

uuugauagac auccaauagc ugcacuauua uguuauccug cagcuagaua ucugauggga      540

agcaugacac cacaagcagu auuagcauuc guagcuuuaa uucccccaac auuaccaggc      600

acaaauauag uucuuggagc uuuaccagaa gauagacaua uagauagauu ggccaaaaga      660

caaagaccag gagaaagacu agauuuagcu auguuagcag caauaagaag aguuuacggu      720

uuauuagcaa acacaguaag auaucuacaa ggaggaggua guuggagaga agauugggga      780

caauuaagug gaacagcugu accaccacaa ggagcagaac cacaaucaaa ugcuggacca      840

cgaccacaua uaggagacac acuauuuaca cuauuuagag caccagaacu cuuagcuccc      900

aauggagauu uauauaaugu uuuugccugg gccuuagaug uacuagcuaa aagauuaagg      960

ccaaugcacg uauuuauacu agauuacgau caaucacccg caggaugucg agacgcacua     1020

cuacaacuaa ccucaggaau gguccaaacu cauguaacua cacaagcacc auaucgaagg     1080

agcgcaacau ggagagcaag auuaccagga agauggggaa ggcuaacgga aacuagaaaa     1140

gaaacaauuc cagaaggaac uagagcaaug acagcaauaa aaagacaaaa caaaacacau     1200

ggauguuggg uagucuguag uuaa                                            1224


<210>  6849
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9IYZ7

<400>  6849

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asn Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Gly Gly Trp Glu Leu Thr Cys Pro Ala Pro Gly Pro His Pro His 
145                 150                 155                 160 


Leu Arg Pro Pro Ser His Arg Arg Pro Pro Val Leu Pro Gly Arg Ala 
                165                 170                 175     


Ile Pro Tyr Gly Gln His Asp Pro Pro Gly Arg Ala Gly Val Arg Gly 
            180                 185                 190         


Pro His Pro Ala Asp Leu Ala Arg His Lys His Arg Val Gly Gly Pro 
        195                 200                 205             


Ser Gly Gly Gln Thr His Arg Pro Pro Gly Gln Thr Pro Ala Pro Arg 
    210                 215                 220                 


Arg Ala Ala 
225         


<210>  6850
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6850
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacaa uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg gggggggagg cugggagcuc acaugccccg cccccggccc ucacccucau      480

cuucgaccgc caucccaucg ccgcccuccu gugcuacccg gccgcgcgau accuuauggg      540

cagcaugacc ccccaggccg ugcuggcguu cguggcccuc aucccgccga ccuugcccgg      600

cacaaacauc guguuggggg cccuuccgga ggacagacac aucgaccgcc uggccaaacg      660

ccagcgcccc ggcgagcggc uuga                                             684


<210>  6851
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6851
auggccagcu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacaa caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcgggggcgg gugggagcuc acgugccccg ccccgggccc ccacccccac      480

cuccggcccc cgagccaccg ccggccgccc guccugcccg gccgcgccau ccccuacggg      540

cagcacgacc cgcccggccg ggccggggug cgcggccccc accccgccga ccuggcgcgg      600

cacaagcacc gcgugggcgg gcccuccggc gggcagaccc accggccgcc cggccagacc      660

cccgcgcccc gccgggccgc cuga                                             684


<210>  6852
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6852
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacaa caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcggcgg cugggagcuc accugccccg cccccggccc ccacccccac      480

cuccgccccc ccucccaccg ccgccccccc guccuccccg gccgcgccau ccccuacggc      540

cagcacgacc cccccggccg cgccggcguc cgcggccccc accccgccga ccucgcccgc      600

cacaagcacc gcgucggcgg ccccuccggc ggccagaccc accgcccccc cggccagacc      660

cccgcccccc gccgcgccgc cuga                                             684


<210>  6853
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6853
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacaa uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaacauc      300

uacaccacuc agcacagacu cgaucaggga gaaauuuccg caggcgacgc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggaugc agugcuggcc      420

ccucauauug ggggaggcgg cugggagcuu acuuguccug cuccagggcc ccacccucac      480

cugaggccac cgucgcaucg gcgacccccu gucuugccag gacgcgccau ccccuacggu      540

cagcacgacc cuccaggcag agcaggggug aggggacccc auccggcuga ucucgcccgg      600

cacaagcacc guguaggcgg uccuucaggg ggacagaccc auagaccccc aggccagaca      660

cccgcgcccc gcagggccgc auga                                             684


<210>  6854
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6854
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacaa caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcggcgg cugggagcug accugccccg cccccggccc ccacccccac      480

cugagacccc ccagccacag aagacccccc gugcugcccg gcagagccau ccccuacggc      540

cagcacgacc cccccggcag agccggcgug agaggccccc accccgccga ccuggccaga      600

cacaagcaca gagugggcgg ccccagcggc ggccagaccc acagaccccc cggccagacc      660

cccgccccca gaagagccgc cuga                                             684


<210>  6855
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6855
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacaa uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaacauu      300

uacaccacgc agcaccggcu ggaucagggc gaaaucagcg ccggggacgc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgaugc uguccucgcg      420

ccccauaucg gcggcggggg augggagcug acauguccug ccccgggccc ccacccucac      480

cugagacccc cuucucaucg ccggcccccg gugcucccug ggcgcgccau ccccuacgga      540

cagcacgacc cucccggcag agcugggguu cggggacccc auccugccga ucuggcucgc      600

cacaagcaca gagugggcgg cccgagcggg ggacagaccc aucggccccc uggccagacg      660

cccgccccua gacgcgccgc uuga                                             684


<210>  6856
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72505

<400>  6856
auggcaaguu auccaugcca ucaacacgca ucagcauucg aucaagcagc aagaucaaga       60

ggacauucaa auagaagaac agcauuaaga ccaagaagac aacaagaagc aacagaagua      120

cgauuagaac aaaaaaugcc aacauuauua cgaguauaca uagacggacc acauggaaug      180

gguaaaacaa caacaacaca acuacuagua gcauuaggau caagagauaa uauaguauau      240

guaccagaac cuaugacaua cuggcaagua cuaggagcau cagaaacaau agcaaacauu      300

uacacaacac aacacagacu agaucaagga gaaauaagug caggagaugc agcaguagua      360

augacaucag cacaaauaac aaugggaaug ccauaugcag uaacagaugc aguacuagcg      420

ccacauauag ggggcggagg augggaacua acauguccag caccaggacc acauccacau      480

uuaagaccac caucacauag aagaccacca guacuaccag gaagagcaau accauauggu      540

caacaugauc caccaggacg agcaggugua agaggaccuc auccagcaga cuuagcaaga      600

cauaaacaua gaguaggagg cccaucagga ggacaaacac auagaccacc aggacaaaca      660

cccgcaccca gaagagcagc auaa                                             684


<210>  6857
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9IYZ9

<400>  6857

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Arg Leu Gly Ala His Met Pro Arg Pro Arg Pro Ser Pro Ser Ser 
145                 150                 155                 160 


Ser Thr Ala Ile Pro Ser Pro Pro Ser Cys Ala Thr Arg Pro Arg Asp 
                165                 170                 175     


Thr Leu Trp Ala Ala 
            180     


<210>  6858
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6858
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg gggggaggcu gggagcucac augccccgcc cccggcccuc acccucaucu      480

ucgaccgcca ucccaucgcc gcccuccugu gcuacccggc cgcgcgauac cuuaugggca      540

gcauga                                                                 546


<210>  6859
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6859
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcgggcggcu cggcgcccac augccccgcc cgcggcccag ccccuccagc      480

uccacggcca uccccagccc gcccuccugc gccacccgcc cccgggacac ccugugggcc      540

gcguga                                                                 546


<210>  6860
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6860
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggccgccu cggcgcccac augccccgcc cccgccccuc ccccuccucc      480

uccaccgcca uccccucccc ccccuccugc gccacccgcc cccgcgacac ccucugggcc      540

gccuga                                                                 546


<210>  6861
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6861
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggaaggcu uggcgcccac augccucggc cacgccccuc gccuucaagc      480

aguacugcca ucccaucccc gcccucuugu gcaacccgac cuagagauac acugugggcu      540

gccuga                                                                 546


<210>  6862
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6862
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcagacu gggcgcccac augcccagac ccagacccag ccccagcagc      480

agcaccgcca uccccagccc ccccagcugc gccaccagac ccagagacac ccugugggcc      540

gccuga                                                                 546


<210>  6863
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6863
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggccgccu gggggcccac augccuagac cgcggcccuc uccuagcucc      480

agcacagcca uccccucucc ucccuccugu gcuacccgcc cgagagauac gcugugggcc      540

gcuuga                                                                 546


<210>  6864
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72503

<400>  6864
auggcaucau acccaugcca ccaacacgca ucagcauucg accaagcagc aagaucaaga       60

ggacacucaa accgaagaac agcacuaaga ccaagaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacacuacua agaguauaca uagauggccc acacggaaug      180

ggaaaaacaa caacaacaca acuacuugua gcauuaggau caagagacga cauaguauac      240

guaccagaac caaugacaua cuggcaagua cuaggagcau cagaaacaau agcaaacaua      300

uacacaacac aacacagacu agaccaagga gaaauaucag caggagacgc agcaguagua      360

augacaucag cacaaauaac aaugggaaug ccauacgcag uaacagacgc aguauuagca      420

ccacacauag gaggaagacu aggagcacac augccaagac caagaccauc accaagcuca      480

agcacagcaa uaccaucacc accaucaugc gcaacaagac caagagacac acuaugggca      540

gcauaa                                                                 546


<210>  6865
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9IZ02

<400>  6865

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Asn Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Lys Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Leu Pro Arg Gln 
                85                  90                  95      


Ser Arg Thr Ser Thr Pro His Asn Thr Ala Ser Thr Arg Val Arg Tyr 
            100                 105                 110         


Arg Pro Gly Thr Arg Arg Trp 
        115                 


<210>  6866
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6866
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauaaca accgacguac ggcguugcgc ccucgccggc agcaaaaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ccacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug uuggggcuuc cgagacaauc gcgaacaucu      300

acaccacaca acaccgccuc gaccagggug agauaucggc cggggacgcg gcggugguaa      360


<210>  6867
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6867
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacaaca accgccggac cgcccugcgc ccgcggcgcc agcagaaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggcu cccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcgcgug cucgggcugc cccggcagag ccgcaccucc      300

acgccccaca acaccgccag cacccgggug cgcuaccggc ccggcacccg ccggugguga      360


<210>  6868
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6868
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacaaca accgccgcac cgcccuccgc ccccgccgcc agcagaaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggccucc cccgccaguc ccgcaccucc      300

accccccaca acaccgccuc cacccgcguc cgcuaccgcc ccggcacccg ccgcugguga      360


<210>  6869
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6869
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacaaca aucggcgcac cgcucugcga ccucguagac agcagaaggc cacagaggug      120

aggcucgaac agaaaaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaagacga ccacaacuca auuguuaguu gcacugggcu cacgcgacga uauuguguac      240

guacccgagc cuaugaccua uuggagagug cuagggcucc caaggcagag ucggacaagc      300

acuccccaca acaccgccuc cacacgcguc cgauacagac cuggaaccag gcggugguga      360


<210>  6870
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6870
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacaaca acagaagaac cgcccugaga cccagaagac agcagaaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggccugc ccagacagag cagaaccagc      300

accccccaca acaccgccag caccagagug agauacagac ccggcaccag aagaugguga      360


<210>  6871
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6871
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacaaca aucgcagaac cgcccugcgg ccucgcagac agcagaaggc cacagaggug      120

cggcucgaac agaaaaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaagacca caaccacaca acugcucguu gcucugggga gcagagacga uauuguguac      240

gugccugagc ccaugaccua uuggcggguc cuuggacugc cucgccaguc cagaacaucu      300

acgccccaca acaccgccag cacccgggug cgcuacagac cuggcacacg gcgcugguga      360


<210>  6872
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72499

<400>  6872
auggcaagcu auccauguca ccaacacgca agcgcauucg aucaagcagc aagaagcaga       60

ggacauaaca auagaagaac agcauuaaga ccaagaagac aacaaaaagc aacagaagua      120

agauuagaac aaaaaaugcc aacacuauua agaguauaca uagacggacc acacggaaug      180

ggaaaaacaa caacaacaca auuauuagua gcauuaggau caagagauga cauaguauau      240

guaccagaac caaugacaua cuggagagua cuaggacuac caagacaaag cagaacauca      300

acaccacaca auacagcaag cacaagagua agauauagac caggaacaag aagaugguaa      360


<210>  6873
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9IZ03

<400>  6873

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Ile Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr 
            100             


<210>  6874
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6874
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc aacaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgauaacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacau aa                                                          312


<210>  6875
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6875
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcguguaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaucaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgu ga                                                          312


<210>  6876
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6876
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaucaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccu ga                                                          312


<210>  6877
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6877
auggccagcu accccugcca ccagcaugcu uccgcauucg accaggccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuauaaccua uuggcaagug cuaggggcca gcgagacaau cgcuaauauu      300

uacaccacuu ga                                                          312


<210>  6878
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6878
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaucaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccu ga                                                          312


<210>  6879
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6879
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaucaccua uuggcagguc cuuggagccu cugagacaau ugcuaauauc      300

uacaccacgu ga                                                          312


<210>  6880
<211>  312
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72498

<400>  6880
auggcaucau acccaugcca ccaacacgca ucagcauucg accaagcagc aagaucaaga       60

ggacacucaa acagaagaac agcacuaaga ccaagaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacacuacua agaguauaca uagacggacc acacggaaug      180

ggaaaaacaa caacaacaca acuacuagua gcacuaggau caagagacga cauaguauac      240

guaccagaac caauaacaua cuggcaagua cuaggagcau cagaaacaau agcaaacaua      300

uacacaacau aa                                                          312


<210>  6881
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9IZ07

<400>  6881

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Gly Gly Trp Glu Leu Thr Cys Pro Ala Pro Gly Pro His Pro His 
145                 150                 155                 160 


Leu Arg Pro Ala Ser His Arg Arg Pro Pro Val Leu Pro Gly Arg Ala 
                165                 170                 175     


Val Pro Tyr Gly Gln His Asp Pro Pro Gly Arg Ala Gly Val Arg Gly 
            180                 185                 190         


Pro His Pro Ala Asp Leu Ala Arg His Lys His Arg Val Gly Gly Pro 
        195                 200                 205             


Ser Gly Gly Gln Thr His Arg Pro Pro Gly Gln Thr Pro Ala Pro Arg 
    210                 215                 220                 






<210>  6882
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6882
auggcuucgu accccggcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcgggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg gggggggagg cugggagcuc acaugccccg cccccggccc ucacccucau      480

cuucgaccgg caucccaucg ccgcccuccu gugcuacccg gccgcgcggu accuuauggg      540

cagcaugacc ccccaggccg ugcuggcguu cguggcccuc aucccgccga ccuugcccgg      600

cacaaacauc guguuggggg cccuuccgga ggacagacac aucgaccgcc uggccaaacg      660

ccagcgcccc gguga                                                       675


<210>  6883
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6883
auggccagcu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcagccgg       60

gggcacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacggccc ccacgggaug      180

ggcaagacca ccaccacgca gcuccuggug gcgcugggga gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcgcgug cucggcgccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccggcu ggaccagggc gagaucagcg ccggggacgc ggccgugguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg ggggcggggg cugggagcuc acgugccccg ccccgggccc ccacccccac      480

cuccgccccg ccagccaccg gcgcccgccc guccugcccg ggcgggccgu gcccuacggc      540

cagcacgacc cgcccgggcg cgccggcgug cggggccccc accccgcgga ccuggcccgc      600

cacaagcacc gggucggggg cccguccggg ggccagaccc accgcccgcc cgggcagacc      660

cccgcgcccc gguga                                                       675


<210>  6884
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6884
auggccuccu accccggcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcgcguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcggcgg cugggagcuc accugccccg cccccggccc ccacccccac      480

cuccgccccg ccucccaccg ccgccccccc guccuccccg gccgcgccgu ccccuacggc      540

cagcacgacc cccccggccg cgccggcguc cgcggccccc accccgccga ccucgcccgc      600

cacaagcacc gcgucggcgg ccccuccggc ggccagaccc accgcccccc cggccagacc      660

cccgcccccc gcuga                                                       675


<210>  6885
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6885
auggccagcu accccggcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

gggcacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgauggacc gcaugguaug      180

ggcaaaacga ccacaacuca auuguuaguu gcacugggga gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggagagug cuaggagcca gcgagacaau agcuaauauc      300

uacaccacuc agcacaggcu cgaccagggc gaaauuuccg ccggugaugc cgcugucgug      360

augacaucug cccagaucac cauggggaug ccauaugcgg uuacggacgc agugcuggca      420

ccccauauug gaggcggcgg gugggagcuu acuugcccug cuccaggacc ccacccucau      480

cugcggccag ccucgcaccg ccgaccgccc gucuugccug guagagcagu gccauacggc      540

caacacgauc ccccugggag ggcuggagua cggggcccac aucccgccga ccucgcgcgu      600

cacaagcacc gcguuggugg gccgucagga ggccagaccc auagaccucc cggccagaca      660

ccagccccua gguga                                                       675


<210>  6886
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6886
auggccagcu accccggcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggagagug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcggcgg cugggagcug accugccccg cccccggccc ccacccccac      480

cugagacccg ccagccacag aagacccccc gugcugcccg gcagagccgu gcccuacggc      540

cagcacgacc cccccggcag agccggcgug agaggccccc accccgccga ccuggccaga      600

cacaagcaca gagugggcgg ccccagcggc ggccagaccc acagaccccc cggccagacc      660

cccgccccca gauga                                                       675


<210>  6887
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6887
auggccagcu accccggcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

gggcacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgauggacc ccauggcaug      180

gggaaaacca caaccacaca acugcucguu gcucugggau ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcggguc cuuggcgccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccgccu ggaccagggg gaaaucagcg ccggagaugc ggccgugguu      360

augaccuccg cucagauuac aaugggcaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcgggggagg cugggagcug acaugcccug ccccggggcc ccacccucac      480

cugagacccg ccucucaucg gcgcccuccc gugcucccgg gacgcgcugu uccuuacggc      540

caacacgauc ccccugggcg ggccggagug cgcggccccc aucccgcuga ccuggccaga      600

cacaagcacc gggucggcgg gccuagcgga ggccagaccc auagaccgcc cgggcagacg      660

ccugccccca gauga                                                       675


<210>  6888
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72494

<400>  6888
auggcaucau auccaggaca ccaacacgcc agcgcauuug aucaagcagc acgaagcaga       60

ggacauucaa auaggagaac agcauuacga ccacgaagac aacaagaagc aacagaagua      120

agacuagaac aaaaaaugcc aacauuacua agaguauaca uagauggacc acauggaaug      180

ggaaaaacaa caacaacaca acuauuagua gcauuaggcu caagagacga uauaguauau      240

guaccagaac caaugaccua cuggagagua cuaggagcau cagaaacaau agcaaacaua      300

uauacaacac aacauagauu agaucaagga gaaauaucag caggagacgc agcaguagua      360

augacaucag cacaaauaac caugggaaug ccauaugcag uaacagaugc aguacuagca      420

ccacauauag gaggaggagg augggaauua acauguccag caccaggacc acauccacau      480

uuaagaccag caucacauag aaggccacca guauuaccag gaagagcagu cccauacgga      540

caacaugauc cuccaggaag agcaggagua agaggaccac auccagcaga ccuagcaaga      600

cacaaacaca gaguaggagg accaucagga ggacaaacac auagaccacc aggacaaaca      660

ccagcaccaa gauaa                                                       675


<210>  6889
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__Q9QNF7

<400>  6889

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  6890
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6890
auggcuucgu accccugcca ucaacacgcg ucugcguucg accaggcugc gcguucucgc       60

ggccauagca accgacguac ggcguugcgc ccucgccggc agcaagaagc cacggaaguc      120

cgccuggagc agaaaaugcc cacgcuacug cggguuuaua uagacggucc ucacgggaug      180

gggaaaacca ccaccacgca acugcuggug gcccuggguu cgcgcgacga uaucgucuac      240

guacccgagc cgaugacuua cuggcaggug cugggggcuu ccgagacaau cgcgaacauc      300

uacaccacac aacaccgccu cgaccagggu gagauaucgg ccggggacgc ggcgguggua      360

augacaagcg cccagauaac aaugggcaug ccuuaugccg ugaccgacgc cguucuggcu      420

ccucauaucg ggggggaggc ugggagcuca caugccccgc ccccggcccu cacccucauc      480

uucgaccgcc aucccaucgc cgcccuccug ugcuacccgg ccgcgcgaua ccuuaugggc      540

agcaugaccc cccaggccgu gcuggcguuc guggcccuca ucccgccgac cuugcccggc      600

acaaacaucg uguugggggc ccuuccggag gacagacaca ucgaccgccu ggccaaacgc      660

cagcgccccg gcgagcggcu ugaccuggcu augcuggccg cgauucgccg cguuuacggg      720

cugcuugcca auacggugcg guaucugcag ggcggcgggu cguggcggga ggauugggga      780

cagcuuucgg ggacggccgu gccgccccag ggugccgagc cccagagcaa cgcgggccca      840

cgaccccaua ucggggacac guuauuuacc cuguuucggg cccccgaguu gcuggccccc      900

aacggcgacc uguauaacgu guuugccugg gccuuggacg ucuuggccaa acgccuccgu      960

cccaugcacg ucuuuauccu ggauuacgac caaucgcccg ccggcugccg ggacgcccug     1020

cugcaacuua ccuccgggau gguccagacc cacgucacca ccccaggcuc cauaccgacg     1080

aucugcgacc uggcgcgcac guuugcccgg gagauggggg aggcuaacug a              1131


<210>  6891
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6891
auggccagcu accccugcca ccagcacgcc uccgcguucg accaggccgc ccgcagccgg       60

ggccacucca accgccggac cgcccugcgc ccgcggcgcc agcaggaggc caccgaggug      120

cggcucgagc agaagaugcc cacgcugcug cgcgucuaca ucgacgggcc ccacggcaug      180

gggaagacca ccaccacgca gcuccuggug gcgcugggca gccgggacga caucguguac      240

guccccgagc cgaugaccua cuggcagguc cucggggccu ccgagaccau cgccaacauc      300

uacaccacgc agcaccgccu ggaccagggc gagaucagcg ccggcgacgc ggccguggug      360

augaccuccg cccagaucac cauggggaug cccuacgccg ugaccgacgc cgugcuggcg      420

ccccacaucg gcggggaggc cggcagcucc cacgcgcccc cgcccgcccu cacgcugauc      480

uucgaccggc accccaucgc cgcccugcuc ugcuaccccg ccgcccgcua ccugaugggg      540

agcaugaccc cgcaggccgu ccuggccuuc guggcgcuca ucccgcccac ccugcccggc      600

accaacaucg ugcugggcgc ccuccccgag gaccggcaca ucgaccgccu ggccaagcgg      660

cagcgccccg gggagcggcu ggaccucgcc augcuggccg cgauccgccg ggucuacggc      720

cugcucgcca acacggugcg cuaccugcag ggcgggggcu ccuggcggga ggacuggggg      780

cagcugagcg gcaccgccgu gccgccccag ggggccgagc cccaguccaa cgcgggcccc      840

cgcccccaca ucggggacac ccucuucacc cuguuccgcg cccccgagcu gcucgccccg      900

aacggcgacc uguacaacgu cuucgccugg gcccuggacg ugcucgcgaa gcggcugcgc      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugccg ggacgcccuc     1020

cugcagcuga cguccgggau gguccagacc cacgugacca cccccggcag caucccgacg     1080

aucugcgacc ucgcccgcac cuucgcccgg gagauggggg aggcgaacug a              1131


<210>  6892
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6892
auggccuccu accccugcca ccagcacgcc uccgccuucg accaggccgc ccgcucccgc       60

ggccacucca accgccgcac cgcccuccgc ccccgccgcc agcaggaggc caccgagguc      120

cgccucgagc agaagaugcc cacccuccuc cgcgucuaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcuccucguc gcccucggcu cccgcgacga caucgucuac      240

guccccgagc ccaugaccua cuggcagguc cucggcgccu ccgagaccau cgccaacauc      300

uacaccaccc agcaccgccu cgaccagggc gagaucuccg ccggcgacgc cgccgucguc      360

augaccuccg cccagaucac caugggcaug cccuacgccg ucaccgacgc cguccucgcc      420

ccccacaucg gcggcgaggc cggcuccucc cacgcccccc cccccgcccu cacccucauc      480

uucgaccgcc accccaucgc cgcccuccuc ugcuaccccg ccgcccgcua ccucaugggc      540

uccaugaccc cccaggccgu ccucgccuuc gucgcccuca ucccccccac ccuccccggc      600

accaacaucg uccucggcgc ccuccccgag gaccgccaca ucgaccgccu cgccaagcgc      660

cagcgccccg gcgagcgccu cgaccucgcc augcucgccg ccauccgccg cgucuacggc      720

cuccucgcca acaccguccg cuaccuccag ggcggcggcu ccuggcgcga ggacuggggc      780

cagcucuccg gcaccgccgu ccccccccag ggcgccgagc cccaguccaa cgccggcccc      840

cgcccccaca ucggcgacac ccucuucacc cucuuccgcg cccccgagcu ccucgccccc      900

aacggcgacc ucuacaacgu cuucgccugg gcccucgacg uccucgccaa gcgccuccgc      960

cccaugcacg ucuucauccu cgacuacgac cagucccccg ccggcugccg cgacgcccuc     1020

cuccagcuca ccuccggcau gguccagacc cacgucacca cccccggcuc cauccccacc     1080

aucugcgacc ucgcccgcac cuucgcccgc gagaugggcg aggccaacug a              1131


<210>  6893
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6893
auggccagcu accccugcca ccagcaugcu uccgcauucg accaagccgc gagaucuagg       60

ggccacucaa accggcgcac cgcucugcga ccucguagac agcaggaggc cacagaagug      120

aggcucgagc agaagaugcc aacucuucug cgggucuaua ucgaugggcc gcauggaaug      180

gguaaaacga ccacaacuca auuguuaguu gcacugggca gucgcgacga uauuguguac      240

guacccgaac cuaugaccua uuggcaagug cuaggggcca gcgagacaau agcuaauauc      300

uacaccacuc agcacagacu cgaccaggga gaaauuuccg caggcgaugc cgcugucgug      360

augacaucug cccagaucac cauggguaug ccauaugcgg uuacggacgc agugcuggcu      420

ccccauauug ggggagaggc uggcucguca cacgccccuc cacccgcacu uacucugauc      480

uuugauaggc acccuauagc ugccuugcuc uguuacccag cggcccggua ucugaugggc      540

agcaugaccc cgcaggcagu ccuggcuuuc guggcccuca uucccccuac auuaccaggg      600

acuaacaucg uacugggagc ccuucccgag gaccgccaua ucgaucgauu ggccaagaga      660

cagaggccug gugaacggcu ggaccuagca augcucgccg cuauucgucg cguuuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca guuggaggga ggauuggggu      780

caguuguccg ggacagcagu cccaccccag ggagccgaac cgcagucuaa cgcuggcccu      840

cggccccaca ucggcgacac ccucuuuacg cuguuccgag ccccagaguu acuggcaccu      900

aauggggauc ucuauaacgu guuugccugg gcucuugacg ugcuggccaa acgcuugaga      960

cccaugcaug ucuucauacu agacuacgau caaagcccag caggaugcag ggacgcgcug     1020

cuccagcuga cuuccgguau gguucagaca cacgugacca cucccggcuc aauuccuaca     1080

aucugugauc uugcucggac cuuugcccgc gagauggggg aagcaaauug a              1131


<210>  6894
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6894
auggccagcu accccugcca ccagcacgcc agcgccuucg accaggccgc cagaagcaga       60

ggccacagca acagaagaac cgcccugaga cccagaagac agcaggaggc caccgaggug      120

agacuggagc agaagaugcc cacccugcug agaguguaca ucgacggccc ccacggcaug      180

ggcaagacca ccaccaccca gcugcuggug gcccugggca gcagagacga caucguguac      240

gugcccgagc ccaugaccua cuggcaggug cugggcgcca gcgagaccau cgccaacauc      300

uacaccaccc agcacagacu ggaccagggc gagaucagcg ccggcgacgc cgccguggug      360

augaccagcg cccagaucac caugggcaug cccuacgccg ugaccgacgc cgugcuggcc      420

ccccacaucg gcggcgaggc cggcagcagc cacgcccccc cccccgcccu gacccugauc      480

uucgacagac accccaucgc cgcccugcug ugcuaccccg ccgccagaua ccugaugggc      540

agcaugaccc cccaggccgu gcuggccuuc guggcccuga ucccccccac ccugcccggc      600

accaacaucg ugcugggcgc ccugcccgag gacagacaca ucgacagacu ggccaagaga      660

cagagacccg gcgagagacu ggaccuggcc augcuggccg ccaucagaag aguguacggc      720

cugcuggcca acaccgugag auaccugcag ggcggcggca gcuggagaga ggacuggggc      780

cagcugagcg gcaccgccgu gcccccccag ggcgccgagc cccagagcaa cgccggcccc      840

agaccccaca ucggcgacac ccuguucacc cuguucagag cccccgagcu gcuggccccc      900

aacggcgacc uguacaacgu guucgccugg gcccuggacg ugcuggccaa gagacugaga      960

cccaugcacg uguucauccu ggacuacgac cagagccccg ccggcugcag agacgcccug     1020

cugcagcuga ccagcggcau ggugcagacc cacgugacca cccccggcag cauccccacc     1080

aucugcgacc uggccagaac cuucgccaga gagaugggcg aggccaacug a              1131


<210>  6895
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6895
auggccagcu accccugcca ccagcaugcu uccgccuucg accaagcggc uagaucucgg       60

ggccacagca accgcagaac cgcccugcgg ccucgcagac agcaggaggc cacagaagug      120

cggcucgagc agaagaugcc gacgcugcuu cgcgucuaua ucgaugggcc ccauggaaug      180

ggcaaaacca caaccacaca acugcucguu gcucuggggu ccagagacga uauuguguac      240

gugccugaac ccaugaccua uuggcagguc cuuggagccu cugagacaau cgcuaauauu      300

uacaccacgc agcaccggcu ggaccagggc gaaaucagcg ccggggaugc ggccgugguu      360

augaccuccg cucaaauuac aaugggaaug ccuuaugccg ugaccgacgc uguccucgcg      420

ccccauaucg gcggcgaggc cgggucuagc cacgccccuc cgcccgcucu gacacugauc      480

uuugaucgcc acccuauugc cgcucuccug uguuaccccg ccgccagaua ucuuauggga      540

uccaugaccc cucaggcugu gcuggcguuc guugcccuca uucccccgac gcugccuggc      600

acaaacaucg ugcuuggggc ucugcccgag gaccggcaua ucgaucgccu cgccaagaga      660

cagcggccug gagaacgccu ggaccuggcc augcucgcug ccauuagacg ggucuacggc      720

cugcuugcga auaccgugag auaccugcaa gggggaggca gcuggcgcga ggauuggggc      780

cagcucucug ggacagcugu gccuccccag ggagccgaac cccaguccaa cgccggcccg      840

cggccccaca ucggggacac ccuguuuacc cuuuucagag cuccugagcu gcucgccccc      900

aauggagauc uguauaacgu cuuugcuugg gcccuggacg uucucgcgaa acgccugcgg      960

ccuaugcaug uguucauucu ugacuacgau caaagccccg ccggcugcag agacgcucug     1020

cuccagcuga caucugggau ggugcagacg cacgucacca caccgggauc caucccuacc     1080

aucugugauc uugcccgcac auuugcucgg gagaugggcg aagccaauug a              1131


<210>  6896
<211>  1131
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Thymidine_Kinase_TK__Herpes_Simplex_Virus_1_(HSV-1)__AAF72491

<400>  6896
auggcaaguu acccaugcca ucaacacgcc ucagcauuug aucaagcagc aagaucuaga       60

ggucauagua auagaagaac agcucucaga ccaagaagac aacaagaagc aacagaagua      120

cgauuagaac aaaaaaugcc aacacuacua agaguauaua uagacggacc acauggaaug      180

ggcaaaacaa caacaacaca auuauuagua gcauuagguu cacgagauga uauaguauau      240

guaccagaac caaugacaua uuggcaagua uuaggagcaa gcgaaacuau agcaaauaua      300

uauacaacac aacauagacu agaucaaggu gaaauaagcg caggagaugc agccguagua      360

augacaucag cucaaauaac aaugggaaug ccauaugcag uaacugaugc aguauuagca      420

ccacacauag gaggagaagc aggcucauca caugccccac ccccagcauu aacacuaaua      480

uucgaucgac acccaauagc ugcacuauug uguuauccag cagcuagaua uuuaauggga      540

agcaugacuc cacaagcagu uuuagcauuu guagcauuaa uaccuccaac auuaccagga      600

acaaacauug uacuaggagc acuaccagaa gauagacaua uagauagauu agcaaaaaga      660

caaagaccag gagaaagauu agaucuugca auguuagcug caauaagaag aguauaugga      720

uuauuagcaa acacuguaag auaccuacaa ggaggaggau ccuggagaga agauugggga      780

caauuaagug gaacagcagu acccccacaa ggugcagaac cucaauccaa cgcaggacca      840

agaccccaua uaggagacac uuuauucaca uuauuuagag ccccagaauu auuagcacca      900

aauggcgauu uauauaacgu auuugcaugg gcauuagacg uacuugcaaa aagacuaaga      960

ccuaugcacg uauucauauu agauuaugac caaucaccag caggcugucg agaugccuua     1020

uuacaacuua caucuggaau gguacaaaca cacguaacaa caccaggguc cauaccaaca     1080

aucugugauu uagcacgaac auuugcuaga gaaaugggug aagccaauua a              1131


<210>  6897
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Apo2L/TRAIL__Homo_sapiens__P50591

<400>  6897

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  6898
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6898
auggcuauga uggaggucca ggggggaccc agccugggac agaccugcgu gcugaucgug       60

aucuucacag ugcuccugca gucucucugu guggcuguaa cuuacgugua cuuuaccaac      120

gagcugaagc agaugcagga caaguacucc aaaaguggca uugcuuguuu cuuaaaagaa      180

gaugacaguu auugggaccc caaugacgaa gagaguauga acagccccug cuggcaaguc      240

aaguggcaac uccgucagcu cguuagaaag augauuuuga gaaccucuga ggaaaccauu      300

ucuacaguuc aagaaaagca acaaaauauu ucuccccuag ugagagaaag agguccucag      360

agaguagcag cucacauaac ugggaccaga ggaagaagca acacauuguc uucuccaaac      420

uccaagaaug aaaaggcucu gggccgcaaa auaaacuccu gggaaucauc aaggaguggg      480

cauucauucc ugagcaacuu gcacuugagg aauggugaac uggucaucca ugaaaaaggg      540

uuuuacuaca ucuauuccca aacauacuuu cgauuucagg aggaaauaaa agaaaacaca      600

aagaacgaca aacaaauggu ccaauauauu uacaaauaca caaguuaucc ugacccuaua      660

uuguugauga aaagugcuag aaauaguugu uggucuaaag augcagaaua uggacucuau      720

uccaucuauc aagggggaau auuugagcuu aaggaaaaug acagaauuuu uguuucugua      780

acaaaugagc acuugauaga cauggaccau gaagccaguu uuuucggggc cuuuuuaguu      840

ggcuaa                                                                 846


<210>  6899
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6899
auggccauga uggaggugca gggcgggccc agccugggcc agaccugcgu ccucaucgug       60

aucuucaccg ugcugcugca gucccucugc gucgccguga cguacgugua cuucaccaac      120

gagcugaagc agaugcagga caaguacagc aaguccggga ucgcgugcuu ccugaaggag      180

gacgacagcu acugggaccc gaacgacgag gaguccauga acagccccug cuggcagguc      240

aaguggcagc uccgccagcu ggugcggaag augauccugc gcaccuccga ggagaccauc      300

agcacggugc aggagaagca gcagaacauc agcccccucg uccgggagcg cggcccccag      360

cggguggccg cccacaucac cgggacccgc ggccggucca acacccuguc cagcccgaac      420

uccaagaacg agaaggcccu gggccgcaag aucaacagcu gggaguccag ccgguccggg      480

cacagcuucc ucuccaaccu gcaccuccgc aacggcgagc uggugaucca cgagaagggg      540

uucuacuaca ucuacagcca gacguacuuc cgguuccagg aggagaucaa ggagaacacc      600

aagaacgaca agcagauggu ccaguacauc uacaaguaca ccagcuaccc cgaccccauc      660

cugcugauga aguccgcccg caacagcugc ugguccaagg acgcggagua cggccucuac      720

agcaucuacc agggcgggau cuucgagcug aaggagaacg accggaucuu cguguccgug      780

accaacgagc accugaucga cauggaccac gaggccagcu ucuucggcgc cuuccucguc      840

ggguga                                                                 846


<210>  6900
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6900
auggccauga uggaggucca gggcggcccc ucccucggcc agaccugcgu ccucaucguc       60

aucuucaccg uccuccucca gucccucugc gucgccguca ccuacgucua cuucaccaac      120

gagcucaagc agaugcagga caaguacucc aaguccggca ucgccugcuu ccucaaggag      180

gacgacuccu acugggaccc caacgacgag gaguccauga acucccccug cuggcagguc      240

aaguggcagc uccgccagcu cguccgcaag augauccucc gcaccuccga ggagaccauc      300

uccaccgucc aggagaagca gcagaacauc uccccccucg uccgcgagcg cggcccccag      360

cgcgucgccg cccacaucac cggcacccgc ggccgcucca acacccucuc cucccccaac      420

uccaagaacg agaaggcccu cggccgcaag aucaacuccu gggaguccuc ccgcuccggc      480

cacuccuucc ucuccaaccu ccaccuccgc aacggcgagc ucgucaucca cgagaagggc      540

uucuacuaca ucuacuccca gaccuacuuc cgcuuccagg aggagaucaa ggagaacacc      600

aagaacgaca agcagauggu ccaguacauc uacaaguaca ccuccuaccc cgaccccauc      660

cuccucauga aguccgcccg caacuccugc ugguccaagg acgccgagua cggccucuac      720

uccaucuacc agggcggcau cuucgagcuc aaggagaacg accgcaucuu cgucuccguc      780

accaacgagc accucaucga cauggaccac gaggccuccu ucuucggcgc cuuccucguc      840

ggcuga                                                                 846


<210>  6901
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6901
auggccauga uggaggugca gggcgggccc agccugggac aaaccugcgu ccucaucguu       60

auuuucacag ugcuucugca guccuugugu guagcuguga cuuacgucua uuuuacgaac      120

gaauuaaagc agaugcagga caaauacucu aagucaggua uagcaugcuu ccugaaagag      180

gaugacaguu auugggaucc uaaugacgaa gagagcauga acuccccaug uuggcaagug      240

aaguggcagc uaagacagcu cguuaggaaa augauccugc ggaccucuga agagacaauu      300

ucgacugugc aggagaagca acagaauauc ucaccgcuug uccgcgaacg aggcccccag      360

cguguggccg cgcacauuac cgggacaaga ggaaggagca acacccugag uuccccuaau      420

ucuaagaacg agaaggcuuu gggccggaaa aucaauagcu gggaauccuc acgcaguggu      480

cauagcuuuc ucucuaaccu gcaccugaga aauggggagc ucguaauaca ugagaaagga      540

uucuacuaua ucuacuccca gacuuauuuu agguuccaag aagagauuaa ggaaaacacc      600

aaaaaugaua agcagauggu ucaguacauc uacaaguaua caucauaccc agaccccauu      660

uuacugauga aaagcgcccg gaacaguugc uggucuaagg augcagagua uggccuuuac      720

uccaucuauc aaggcgggau auuugaauug aaagagaaug accgcauuuu cgugagcguc      780

acgaacgagc accugaucga uauggaccau gaagccucgu uuuucggagc uuuucuagug      840

gguuga                                                                 846


<210>  6902
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6902
auggccauga uggaggugca gggcggcccc agccugggcc agaccugcgu gcugaucgug       60

aucuucaccg ugcugcugca gagccugugc guggccguga ccuacgugua cuucaccaac      120

gagcugaagc agaugcagga caaguacagc aagagcggca ucgccugcuu ccugaaggag      180

gacgacagcu acugggaccc caacgacgag gagagcauga acagccccug cuggcaggug      240

aaguggcagc ugagacagcu ggugagaaag augauccuga gaaccagcga ggagaccauc      300

agcaccgugc aggagaagca gcagaacauc agcccccugg ugagagagag aggcccccag      360

agaguggccg cccacaucac cggcaccaga ggcagaagca acacccugag cagccccaac      420

agcaagaacg agaaggcccu gggcagaaag aucaacagcu gggagagcag cagaagcggc      480

cacagcuucc ugagcaaccu gcaccugaga aacggcgagc uggugaucca cgagaagggc      540

uucuacuaca ucuacagcca gaccuacuuc agauuccagg aggagaucaa ggagaacacc      600

aagaacgaca agcagauggu gcaguacauc uacaaguaca ccagcuaccc cgaccccauc      660

cugcugauga agagcgccag aaacagcugc uggagcaagg acgccgagua cggccuguac      720

agcaucuacc agggcggcau cuucgagcug aaggagaacg acagaaucuu cgugagcgug      780

accaacgagc accugaucga cauggaccac gaggccagcu ucuucggcgc cuuccuggug      840

ggcuga                                                                 846


<210>  6903
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6903
auggccauga uggaggugca gggcgggccc agccugggac aaaccugcgu ccucaucguu       60

auuuucacag ugcugcuuca gucccugugu guggcuguca cguacgugua uuuuaccaac      120

gaacucaagc agaugcagga caaauacucu aagagcggca ucgccugcuu ccugaaagag      180

gaugacuccu auugggaucc uaaugacgaa gagucuauga acagcccgug uuggcaaguu      240

aaguggcagc uuagacagcu ggugcggaaa augauucucc gcacauccga agagaccauc      300

ucuacagucc aggagaagca acagaauauu agcccccugg ugagagaacg ggggccucag      360

cgcguugcgg cucacaucac cggaacaaga ggccggucca acacccugag cucucccaau      420

uccaagaacg agaaagcccu cgggcgcaag aucaauagcu gggaaucuuc cagaagcgga      480

cauucuuuuc uguccaaccu ucaucugcgg aauggcgagc ucgugauuca cgagaaaggc      540

uucuacuaua ucuacagcca gacguauuuu cgcuuccaag aagagauuaa ggaaaacacc      600

aaaaaugaua agcagauggu ccaguacauc uacaaguaua cauccuaccc ugaccccauu      660

cugcuuauga aaucugccag aaacagcugc ugguccaagg augcugagua ugggcuguac      720

agcaucuauc aaggaggcau uuuugaacuc aaagagaaug accggaucuu cgugucugug      780

accaacgagc accugaucga uauggaccau gaagccuccu uuuucggggc uuuucugguc      840

ggauga                                                                 846


<210>  6904
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Apo2L/TRAIL__Homo_sapiens__AAB01233

<400>  6904
auggcaauga uggaaguaca aggaggacca ucacuaggcc aaacaugugu acuaaucgua       60

auauucacag uacuacuaca aucacuaugc guagcaguaa cauacguaua cuucaccaac      120

gaacuaaaac aaaugcaaga uaaauacagc aaaucaggaa uagcaugcuu ccuaaaagaa      180

gacgacucau acugggaccc aaaugacgaa gaaucaauga acaguccaug uuggcaagua      240

aaauggcaau uacgacaacu aguaagaaaa augauauuaa gaacuuccga agaaacaaua      300

ucaacaguac aagaaaaaca acaaaacaua ucaccauuag uaagagaaag aggaccacaa      360

agaguagcag cccauauaac aggaacaaga ggaagaagca acacacuauc aucaccaaac      420

agcaaaaacg aaaaagcauu aggaagaaaa auaaacucau gggaaucauc aagaucugga      480

cacucauucu uaagcaacuu acaccuaaga aacggagaac uagucaucca cgaaaaagga      540

uucuauuaca uauacucuca aacauacuuu cgcuuccaag aagaaauaaa agaaaacaca      600

aaaaacgaca aacaaauggu acaauacaua uacaaauaca caucauaucc agacccaauc      660

uuacuaauga aauccgcacg aaacucaugu uggucaaaag acgcagaaua cggacuauac      720

ucaauauauc aaggaggaau auuugaacua aaagaaaacg acagaauauu cguaucagua      780

acaaacgaac accuaauaga cauggaccac gaagcaucau ucuucggagc auuccuagua      840

ggauaa                                                                 846


<210>  6905
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Apo3L__Homo_sapiens__O43508

<400>  6905

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  6906
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Apo3L__Homo_sapiens__AAC39724

<400>  6906
auggccgccc gucggagcca gaggcggagg gggcgccggg gggagccggg caccgcccug       60

cuggucccgc ucgcgcuggg ccugggccug gcgcuggccu gccucggccu ccugcuggcc      120

guggucaguu uggggagccg ggcaucgcug uccgcccagg agccugccca ggaggagcug      180

guggcagagg aggaccagga cccgucggaa cugaaucccc agacagaaga aagccaggau      240

ccugcgccuu uccugaaccg acuaguucgg ccucgcagaa gugcaccuaa aggccggaaa      300

acacgggcuc gaagagcgau cgcagcccau uaugaaguuc auccacgacc uggacaggac      360

ggagcgcagg caggugugga cgggacagug aguggcuggg aggaagccag aaucaacagc      420

uccagcccuc ugcgcuacaa ccgccagauc ggggaguuua uagucacccg ggcugggcuc      480

uacuaccugu acugucaggu gcacuuugau gaggggaagg cugucuaccu gaagcuggac      540

uugcuggugg auggugugcu ggcccugcgc ugccuggagg aauucucagc cacugcggcg      600

aguucccucg ggccccagcu ccgccucugc caggugucug ggcuguuggc ccugcggcca      660

ggguccuccc ugcggauccg cacccucccc ugggcccauc ucaaggcugc ccccuuccuc      720

accuacuucg gacucuucca gguucacuga                                       750


<210>  6907
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6907
auggccgccc gccggagcca gcgccggcgc gggcggcgcg gggagcccgg caccgcgcug       60

cucgugccgc uggcccuggg gcucggccug gcccuggccu gccucgggcu gcugcucgcc      120

gucguguccc ugggcagccg ggcgucccug agcgcccagg agcccgccca ggaggagcuc      180

guggccgagg aggaccagga ccccuccgag cugaaccccc agaccgagga gagccaggac      240

ccggcgcccu uccugaaccg ccucguccgg ccccgccggu ccgcccccaa gggccgcaag      300

acgcgggccc gccgggccau cgccgcgcac uacgaggugc acccgcgccc cgggcaggac      360

ggcgcccagg ccggggugga cggcaccguc agcggguggg aggaggcccg gaucaacucc      420

agcagccccc ugcgcuacaa ccggcagauc ggcgaguuca ucgugacccg cgccggccug      480

uacuaccucu acugccaggu gcacuucgac gaggggaagg cggucuaccu gaagcuggac      540

cuccuggugg acggcgugcu ggcccuccgg ugccuggagg aguucuccgc caccgccgcc      600

uccagccugg ggccccagcu ccgccugugc caggucuccg gccugcucgc gcugcgcccg      660

ggcagcuccc ugcggauccg cacgcucccc ugggcccacc ugaaggccgc ccccuuccug      720

accuacuucg gccucuucca ggugcacuga                                       750


<210>  6908
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6908
auggccgccc gccgcuccca gcgccgccgc ggccgccgcg gcgagcccgg caccgcccuc       60

cucguccccc ucgcccucgg ccucggccuc gcccucgccu gccucggccu ccuccucgcc      120

gucgucuccc ucggcucccg cgccucccuc uccgcccagg agcccgccca ggaggagcuc      180

gucgccgagg aggaccagga ccccuccgag cucaaccccc agaccgagga gucccaggac      240

cccgcccccu uccucaaccg ccucguccgc ccccgccgcu ccgcccccaa gggccgcaag      300

acccgcgccc gccgcgccau cgccgcccac uacgaggucc acccccgccc cggccaggac      360

ggcgcccagg ccggcgucga cggcaccguc uccggcuggg aggaggcccg caucaacucc      420

uccucccccc uccgcuacaa ccgccagauc ggcgaguuca ucgucacccg cgccggccuc      480

uacuaccucu acugccaggu ccacuucgac gagggcaagg ccgucuaccu caagcucgac      540

cuccucgucg acggcguccu cgcccuccgc ugccucgagg aguucuccgc caccgccgcc      600

uccucccucg gcccccagcu ccgccucugc caggucuccg gccuccucgc ccuccgcccc      660

ggcuccuccc uccgcauccg cacccucccc ugggcccacc ucaaggccgc ccccuuccuc      720

accuacuucg gccucuucca gguccacuga                                       750


<210>  6909
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6909
auggccgcua gaaggagcca gcggcgccga ggccguagag gggagcccgg aaccgcacug       60

cucgugccuc uugcccuggg uuugggcuua gcgcuggcuu gccuagggcu ccugcuugcc      120

gucguuuccc ugggaucuag ggcaucauug agugcccaag aaccagcuca ggaggaacuc      180

guggcagagg aagaccagga uccgagcgag cugaaccccc agacagagga aucccaagac      240

ccugccccau uccugaaucg gcucguacgc cccagaaggu cugcuccuaa gggccggaaa      300

acucgcgcca gacgagcgau cgcagcccac uacgaggugc auccaaggcc cggucaggau      360

ggggcucagg ccggagucga cggcacggug ucgggcuggg aagaggcacg gauuaacuca      420

agcaguccuu uacguuauaa ucgccagaua ggggaguuua ucguuaccag agcuggacug      480

uacuaucuuu acugucaagu gcacuucgau gaagguaagg ccgucuauuu gaaacuggac      540

cuacucgugg auggcguacu ggcgcuuagg ugccuggagg aauuuuccgc cacagcagcu      600

ucuagcuugg ggccacagcu ccggcugugu cagguuuccg gauuacuggc ccuccgaccg      660

ggcucaaguc uucgcauuag aacucugccc ugggcucauu ugaaggccgc accuuuccua      720

accuacuuug gucuguucca ggugcacuga                                       750


<210>  6910
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6910
auggccgcca gaagaagcca gagaagaaga ggcagaagag gcgagcccgg caccgcccug       60

cuggugcccc uggcccuggg ccugggccug gcccuggccu gccugggccu gcugcuggcc      120

guggugagcc ugggcagcag agccagccug agcgcccagg agcccgccca ggaggagcug      180

guggccgagg aggaccagga ccccagcgag cugaaccccc agaccgagga gagccaggac      240

cccgcccccu uccugaacag acuggugaga cccagaagaa gcgcccccaa gggcagaaag      300

accagagcca gaagagccau cgccgcccac uacgaggugc accccagacc cggccaggac      360

ggcgcccagg ccggcgugga cggcaccgug agcggcuggg aggaggccag aaucaacagc      420

agcagccccc ugagauacaa cagacagauc ggcgaguuca ucgugaccag agccggccug      480

uacuaccugu acugccaggu gcacuucgac gagggcaagg ccguguaccu gaagcuggac      540

cugcuggugg acggcgugcu ggcccugaga ugccuggagg aguucagcgc caccgccgcc      600

agcagccugg gcccccagcu gagacugugc caggugagcg gccugcuggc ccugagaccc      660

ggcagcagcc ugagaaucag aacccugccc ugggcccacc ugaaggccgc ccccuuccug      720

accuacuucg gccuguucca ggugcacuga                                       750


<210>  6911
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6911
auggccgcua gacggagcca gcgcagacgg ggccgcagag gggagcccgg aaccgcccug       60

cucgugccuc uggcgcuugg ccuggggcuc gcucuggccu gccuuggacu gcuccuggcc      120

gucguuuccc ugggcucucg ggcuagccuc uccgcccaag aaccggcuca ggaggaacug      180

guggccgagg aagaccagga ucccucugag cuuaacccuc agacagagga aagccaagac      240

cccgcgccuu uccugaaucg ccucgugaga ccccggcgcu ccgccccuaa ggggagaaaa      300

acgcgggcuc gcagagccau cgcugcccac uacgaggucc auccgcggcc cggacaggau      360

ggcgcgcagg ccggcgugga cgggaccguu ucuggauggg aagaggcucg cauuaacagc      420

uccagcccuc ugagauauaa ucggcagauc ggcgaguuua uugugacaag agccgggcuu      480

uacuaucugu acugucaagu ccacuucgau gaaggaaagg cuguguaucu caaacuggac      540

cugcucguug auggcgugcu ggcccuucgc ugccuggagg aauuuucugc caccgcugcg      600

uccagccucg ggccccagcu gcggcuuugu caggucucug gacugcucgc ccugagaccu      660

ggcuccagcc ugcgcauccg gacacucccc ugggcucauc ugaaggccgc cccguuccuu      720

accuacuuug gccuguucca ggugcacuga                                       750


<210>  6912
<211>  750
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Apo3L__Homo_sapiens__AAC39724

<400>  6912
auggcagcua gaagaucaca aagaagaaga ggaagaagag gagaaccagg uacagcccua       60

uuaguaccau uagcauuagg auuaggcuua gcauuagcau guuuaggauu acuauuagca      120

gucguaucac uaggcucaag agcaagucua ucagcacaag aaccagcaca agaagaauua      180

guagcagaag aagaccaaga uccaagcgaa uuaaauccac aaacagaaga aucacaagau      240

ccagcacccu uucuaaaucg auuaguacga cccagaagaa gugcaccaaa aggaagaaaa      300

acaagagcaa gacgagcuau agcagcacau uaugaaguac auccaagacc aggacaagau      360

ggagcacaag caggaguuga uggaacagua ucaggauggg aagaagcuag aauaaauuca      420

ucaucaccac uaagauauaa cagacaaauu ggagaauuua uaguaacaag agcaggauua      480

uauuauuuau auugucaagu acauuuugau gaaggaaaag caguauauuu aaaacuagau      540

cuauuaguag auggaguacu agcauuaaga ugucuagaag aauuuagugc uacagcagca      600

ucaagucuag gaccucaauu aagauuaugu caaguaagug gacuauuagc auuaagacca      660

ggaagcucau uaagaauacg uacauuacca ugggcacauu uaaaagcagc accauuuuua      720

acauacuuug gauuauucca aguacauuaa                                       750


<210>  6913
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bad__Homo_sapiens__A0A024R562

<400>  6913

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  6914
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bad__Homo_sapiens__EAW74236

<400>  6914
auguuccaga ucccagaguu ugagccgagu gagcaggaag acuccagcuc ugcagagagg       60

ggccugggcc ccagccccgc aggggacggg cccucaggcu ccggcaagca ucaucgccag      120

gccccaggcc uccuguggga cgccagucac cagcaggagc agccaaccag cagcagccau      180

cauggaggcg cuggggcugu ggagauccgg agucgccaca gcuccuaccc cgcggggacg      240

gaggacgacg aagggauggg ggaggagccc agccccuuuc ggggccgcuc gcgcucggcg      300

ccccccaacc ucugggcagc acagcgcuau ggccgcgagc uccggaggau gagugacgag      360

uuuguggacu ccuuuaagaa gggacuuccu cgcccgaaga gcgcgggcac agcaacgcag      420

augcggcaaa gcuccagcug gacgcgaguc uuccaguccu ggugggaucg gaacuugggc      480

aggggaagcu ccgcccccuc ccaguga                                          507


<210>  6915
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bad__Homo_sapiens__EAW74236

<400>  6915
auguuccaga uccccgaguu cgagccgagc gagcaggagg acuccagcuc cgccgagcgc       60

ggccuggggc ccagccccgc cggcgacggg cccuccggca gcgggaagca ccaccggcag      120

gcgccgggcc uccuguggga cgccucccac cagcaggagc agcccaccag cuccagccac      180

cacggcgggg ccggcgccgu ggagauccgc ucccggcaca gcuccuaccc cgccgggacc      240

gaggacgacg agggcauggg ggaggagccc agcccguucc gcggccgguc ccgcagcgcg      300

ccgcccaacc ugugggccgc ccagcgguac ggccgcgagc uccggcgcau guccgacgag      360

uucgucgaca gcuucaagaa ggggcugccc cggcccaagu ccgccggcac ggcgacccag      420

augcgccaga gcagcuccug gacccgggug uuccagagcu ggugggaccg caaccugggg      480

cggggcucca gcgcccccuc ccaguga                                          507


<210>  6916
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bad__Homo_sapiens__EAW74236

<400>  6916
auguuccaga uccccgaguu cgagcccucc gagcaggagg acuccuccuc cgccgagcgc       60

ggccucggcc ccucccccgc cggcgacggc cccuccggcu ccggcaagca ccaccgccag      120

gcccccggcc uccucuggga cgccucccac cagcaggagc agcccaccuc cuccucccac      180

cacggcggcg ccggcgccgu cgagauccgc ucccgccacu ccuccuaccc cgccggcacc      240

gaggacgacg agggcauggg cgaggagccc ucccccuucc gcggccgcuc ccgcuccgcc      300

ccccccaacc ucugggccgc ccagcgcuac ggccgcgagc uccgccgcau guccgacgag      360

uucgucgacu ccuucaagaa gggccucccc cgccccaagu ccgccggcac cgccacccag      420

augcgccagu ccuccuccug gacccgcguc uuccaguccu ggugggaccg caaccucggc      480

cgcggcuccu ccgcccccuc ccaguga                                          507


<210>  6917
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bad__Homo_sapiens__EAW74236

<400>  6917
auguuccaga uccccgaguu ugaaccuagc gagcaagaag acuccucuuc agccgagaga       60

ggccuggggc caaguccggc uggagauggu cccagcggcu ccgggaagca ccauaggcag      120

gcaccuggac uccuuuggga cgccucucac cagcaggaac aaccaaccuc gucaagccau      180

cacggcggug cgggggcugu ggagauucgg agucgccauu ccucuuaccc cgccggaaca      240

gaggaugacg aaggcauggg cgaggaaccu agcccauucc gagggcguuc cagaucagca      300

cccccuaacc ugugggccgc ucagagguau ggacgggagu ugcgcagaau gagugaugag      360

uuugucgaca gcuucaaaaa ggguuuacca aggccgaaau cugcaggcac ugccacgcag      420

augcggcagu ccucaagcug gacccgcguu uuucaaaguu ggugggaucg aaaucugggg      480

agaggaucuu ccgcucccag ccaguga                                          507


<210>  6918
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bad__Homo_sapiens__EAW74236

<400>  6918
auguuccaga uccccgaguu cgagcccagc gagcaggagg acagcagcag cgccgagaga       60

ggccugggcc ccagccccgc cggcgacggc cccagcggca gcggcaagca ccacagacag      120

gcccccggcc ugcuguggga cgccagccac cagcaggagc agcccaccag cagcagccac      180

cacggcggcg ccggcgccgu ggagaucaga agcagacaca gcagcuaccc cgccggcacc      240

gaggacgacg agggcauggg cgaggagccc agccccuuca gaggcagaag cagaagcgcc      300

ccccccaacc ugugggccgc ccagagauac ggcagagagc ugagaagaau gagcgacgag      360

uucguggaca gcuucaagaa gggccugccc agacccaaga gcgccggcac cgccacccag      420

augagacaga gcagcagcug gaccagagug uuccagagcu ggugggacag aaaccugggc      480

agaggcagca gcgcccccag ccaguga                                          507


<210>  6919
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bad__Homo_sapiens__EAW74236

<400>  6919
auguuccaga uccccgaguu ugaaccuagc gagcaagaag acuccucuag cgccgagaga       60

ggccuggggc cgucccccgc uggagauggc ccuucuggga gcggaaagca ccaucggcag      120

gcccccggcc uccuguggga cgcgucccac cagcaggaac aaccuaccuc uagcucccau      180

cacgggggag cuggcgccgu ggagauucgc agcagacauu cuuccuaccc cgccggcaca      240

gaggaugacg aagggauggg agaggaaccu agcccguucc ggggccgcuc uagauccgcu      300

cccccuaacc uuugggccgc ucagcgguau gggcgcgagc ugagacggau gagcgaugag      360

uuugucgacu cuuucaaaaa gggacucccc cgcccuaaau ccgccggcac ggcgacccag      420

augagacaga gcuccucuug gacacggguu uuucaaagcu ggugggaucg caaucugggg      480

agaggaucca gcgcccccuc ucaguga                                          507


<210>  6920
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bad__Homo_sapiens__EAW74236

<400>  6920
auguuucaaa uaccagaauu cgaaccaagu gaacaagaag auaguaguag ugcagaaaga       60

ggauuaggac caaguccagc aggagaugga ccaaguggaa guggaaaaca ucauagacaa      120

gcuccaggau uauuauggga ugcaagucau caacaagaac aaccaacaag caguagucau      180

cauggaggag caggagcagu agaaauaaga aguagacaua guaguuaucc ggcaggaaca      240

gaagaugaug aaggaauggg agaagaacca ucaccauuua ggggaagaag uagaagugca      300

ccaccaaauu uaugggcagc acaaagauau ggaagagaau uaagaagaau gagugaugaa      360

uuuguagaua guuuuaaaaa aggauuacca agaccaaaaa gugcaggaac agcaacacaa      420

augaggcaaa guagcaguug gacaagagua uuucaaaguu ggugggauag aaauuuagga      480

agaggaagca gugcaccaag ucaauaa                                          507


<210>  6921
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bad__Homo_sapiens__Q92934

<400>  6921

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  6922
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bad__Homo_sapiens__AAB72092

<400>  6922
auguuccaga ucccagaguu ugagccgagu gagcaggaag acuccagcuc ugcagagagg       60

ggccugggcc ccagccccgc aggggacggg cccucaggcu ccggcaagca ucaucgccag      120

gccccaggcc uccuguggga cgccagucac cagcaggagc agccaaccag cagcagccau      180

cauggaggcg cuggggcugu ggagauccgg agucgccaca gcuccuaccc cgcggggacg      240

gaggacgacg aagggauggg ggaggagccc agccccuuuc ggggccguuc gcgcucggcg      300

ccccccaacc ucugggcagc acagcgcuau ggccgcgagc uccggaggau gagugacgag      360

uuuguggacu ccuuuaagaa gggacuuccu cgcccgaaga gcgcgggcac agcaacgcag      420

augcggcaaa gcuccagcug gacgcgaguc uuccaguccu ggugggaucg gaacuugggc      480

aggggaagcu ccgcccccuc ccaguga                                          507


<210>  6923
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bad__Homo_sapiens__AAB72092

<400>  6923
auguuccaga uccccgaguu cgagccgagc gagcaggagg acuccagcuc cgccgagcgc       60

ggccuggggc ccagccccgc cggcgacggg cccuccggca gcgggaagca ccaccggcag      120

gcgccgggcc uccuguggga cgccucccac cagcaggagc agcccaccag cuccagccac      180

cacggcgggg ccggcgccgu ggagauccgc ucccggcaca gcuccuaccc cgccgggacc      240

gaggacgacg agggcauggg ggaggagccc agcccguucc gcggccgguc ccgcagcgcg      300

ccgcccaacc ugugggccgc ccagcgguac ggccgcgagc uccggcgcau guccgacgag      360

uucgucgaca gcuucaagaa ggggcugccc cggcccaagu ccgccggcac ggcgacccag      420

augcgccaga gcagcuccug gacccgggug uuccagagcu ggugggaccg caaccugggg      480

cggggcucca gcgcccccuc ccaguga                                          507


<210>  6924
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bad__Homo_sapiens__AAB72092

<400>  6924
auguuccaga uccccgaguu cgagcccucc gagcaggagg acuccuccuc cgccgagcgc       60

ggccucggcc ccucccccgc cggcgacggc cccuccggcu ccggcaagca ccaccgccag      120

gcccccggcc uccucuggga cgccucccac cagcaggagc agcccaccuc cuccucccac      180

cacggcggcg ccggcgccgu cgagauccgc ucccgccacu ccuccuaccc cgccggcacc      240

gaggacgacg agggcauggg cgaggagccc ucccccuucc gcggccgcuc ccgcuccgcc      300

ccccccaacc ucugggccgc ccagcgcuac ggccgcgagc uccgccgcau guccgacgag      360

uucgucgacu ccuucaagaa gggccucccc cgccccaagu ccgccggcac cgccacccag      420

augcgccagu ccuccuccug gacccgcguc uuccaguccu ggugggaccg caaccucggc      480

cgcggcuccu ccgcccccuc ccaguga                                          507


<210>  6925
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bad__Homo_sapiens__AAB72092

<400>  6925
auguuccaga uccccgaguu ugaaccuagc gagcaagaag acuccucuuc agccgagaga       60

ggccuggggc caaguccggc uggagauggu cccagcggcu ccgggaagca ccauaggcag      120

gcaccuggac uccuuuggga cgccucucac cagcaggaac aaccaaccuc gucaagccau      180

cacggcggug cgggggcugu ggagauucgg agucgccauu ccucuuaccc cgccggaaca      240

gaggaugacg aaggcauggg cgaggaaccu agcccauucc gagggcguuc cagaucagca      300

cccccuaacc ugugggccgc ucagagguau ggacgggagu ugcgcagaau gagugaugag      360

uuugucgaca gcuucaaaaa ggguuuacca aggccgaaau cugcaggcac ugccacgcag      420

augcggcagu ccucaagcug gacccgcguu uuucaaaguu ggugggaucg aaaucugggg      480

agaggaucuu ccgcucccag ccaguga                                          507


<210>  6926
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bad__Homo_sapiens__AAB72092

<400>  6926
auguuccaga uccccgaguu cgagcccagc gagcaggagg acagcagcag cgccgagaga       60

ggccugggcc ccagccccgc cggcgacggc cccagcggca gcggcaagca ccacagacag      120

gcccccggcc ugcuguggga cgccagccac cagcaggagc agcccaccag cagcagccac      180

cacggcggcg ccggcgccgu ggagaucaga agcagacaca gcagcuaccc cgccggcacc      240

gaggacgacg agggcauggg cgaggagccc agccccuuca gaggcagaag cagaagcgcc      300

ccccccaacc ugugggccgc ccagagauac ggcagagagc ugagaagaau gagcgacgag      360

uucguggaca gcuucaagaa gggccugccc agacccaaga gcgccggcac cgccacccag      420

augagacaga gcagcagcug gaccagagug uuccagagcu ggugggacag aaaccugggc      480

agaggcagca gcgcccccag ccaguga                                          507


<210>  6927
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bad__Homo_sapiens__AAB72092

<400>  6927
auguuccaga uccccgaguu ugaaccuagc gagcaagaag acuccucuag cgccgagaga       60

ggccuggggc cgucccccgc uggagauggc ccuucuggga gcggaaagca ccaucggcag      120

gcccccggcc uccuguggga cgcgucccac cagcaggaac aaccuaccuc uagcucccau      180

cacgggggag cuggcgccgu ggagauucgc agcagacauu cuuccuaccc cgccggcaca      240

gaggaugacg aagggauggg agaggaaccu agcccguucc ggggccgcuc uagauccgcu      300

cccccuaacc uuugggccgc ucagcgguau gggcgcgagc ugagacggau gagcgaugag      360

uuugucgacu cuuucaaaaa gggacucccc cgcccuaaau ccgccggcac ggcgacccag      420

augagacaga gcuccucuug gacacggguu uuucaaagcu ggugggaucg caaucugggg      480

agaggaucca gcgcccccuc ucaguga                                          507


<210>  6928
<211>  507
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bad__Homo_sapiens__AAB72092

<400>  6928
auguuucaaa uaccagaauu ugaaccaagu gaacaagaag auucaaguag ugcagaaaga       60

ggauuaggac caucaccagc aggagaugga ccaaguggaa guggaaaaca ucauagacaa      120

gcaccaggau uauuauggga ugcaucacau caacaagaac aaccaacauc aagcucacau      180

cauggaggag caggagcagu agaaauaaga ucaagacaca guucauaucc agcaggaaca      240

gaagaugaug aaggaauggg agaagaacca ucaccauuua gaggaagauc aagaagugca      300

ccaccaaauu uaugggcagc acaaagauau ggaagagaau uaagaagaau gagugaugaa      360

uuuguagaua guuuuaaaaa aggauuacca agaccaaaaa gugcaggaac agcaacacaa      420

augagacaaa guucaagcug gacaagagua uuucaaaguu ggugggauag aaauuuagga      480

agaggaucaa gcgcaccauc acaauaa                                          507


<210>  6929
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bak__Homo_sapiens__Q16611

<400>  6929

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  6930
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bak__Homo_sapiens__AAA74466

<400>  6930
auggcuucgg ggcaaggccc agguccuccc aggcaggagu gcggagagcc ugcccugccc       60

ucugcuucug aggagcaggu agcccaggac acagaggagg uuuuccgcag cuacguuuuu      120

uaccgccauc agcaggaaca ggaggcugaa gggguggcug ccccugccga cccagagaug      180

gucaccuuac cucugcaacc uagcagcacc auggggcagg ugggacggca gcucgccauc      240

aucggggacg acaucaaccg acgcuaugac ucagaguucc agaccauguu gcagcaccug      300

cagcccacgg cagagaaugc cuaugaguac uucaccaaga uugccaccag ccuguuugag      360

aguggcauca auuggggccg ugugguggcu cuucugggcu ucggcuaccg ucuggcccua      420

cacgucuacc agcauggccu gacuggcuuc cuaggccagg ugacccgcuu cguggucgac      480

uucaugcugc aucacugcau ugcccggugg auugcacaga gggguggcug gguggcagcc      540

cugaacuugg gcaauggucc cauccugaac gugcuggugg uucugggugu gguucuguug      600

ggccaguuug ugguacgaag auucuucaaa ucauga                                636


<210>  6931
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bak__Homo_sapiens__AAA74466

<400>  6931
auggccagcg gccaggggcc cggcccgccc cgccaggagu gcggggagcc cgcccugccc       60

uccgcgagcg aggagcaggu cgcccaggac accgaggagg uguuccgguc cuacguguuc      120

uaccgccacc agcaggagca ggaggccgag ggcguggccg ccccggcgga ccccgagaug      180

gucacccucc cccugcagcc cagcuccacg augggccagg uggggcggca gcuggccauc      240

aucggcgacg acaucaaccg ccgguacgac agcgaguucc agaccaugcu ccagcaccuc      300

cagccgaccg ccgagaacgc cuacgaguac uucaccaaga ucgcgacguc ccuguucgag      360

agcgggauca acuggggccg cguggucgcc cugcuggggu ucggcuaccg gcuggcccuc      420

cacguguacc agcacgggcu gaccggcuuc cugggccagg ugacccgcuu cgucguggac      480

uucaugcucc accacugcau cgcccggugg aucgcccagc gcgggggcug gguggcggcc      540

cugaaccugg ggaacggccc cauccucaac guccuggugg ugcugggcgu cgugcuccug      600

gggcaguucg ugguccggcg cuucuucaag uccuga                                636


<210>  6932
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bak__Homo_sapiens__AAA74466

<400>  6932
auggccuccg gccagggccc cggccccccc cgccaggagu gcggcgagcc cgcccucccc       60

uccgccuccg aggagcaggu cgcccaggac accgaggagg ucuuccgcuc cuacgucuuc      120

uaccgccacc agcaggagca ggaggccgag ggcgucgccg cccccgccga ccccgagaug      180

gucacccucc cccuccagcc cuccuccacc augggccagg ucggccgcca gcucgccauc      240

aucggcgacg acaucaaccg ccgcuacgac uccgaguucc agaccaugcu ccagcaccuc      300

cagcccaccg ccgagaacgc cuacgaguac uucaccaaga ucgccaccuc ccucuucgag      360

uccggcauca acuggggccg cgucgucgcc cuccucggcu ucggcuaccg ccucgcccuc      420

cacgucuacc agcacggccu caccggcuuc cucggccagg ucacccgcuu cgucgucgac      480

uucaugcucc accacugcau cgcccgcugg aucgcccagc gcggcggcug ggucgccgcc      540

cucaaccucg gcaacggccc cauccucaac guccucgucg uccucggcgu cguccuccuc      600

ggccaguucg ucguccgccg cuucuucaag uccuga                                636


<210>  6933
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bak__Homo_sapiens__AAA74466

<400>  6933
auggccagcg gccaggggcc cggaccucca agacaagagu gcggugaacc ggcucugccc       60

uccgcaucug aggaacaggu ggcccaggac accgaggaag ucuucagguc auacguuuuc      120

uaucggcacc agcaagagca ggaggcggaa ggcguggcug ccccugcaga uccagagaug      180

guaacacucc cccuucagcc uaguagcacu augggacagg uggggcgcca acuggccauc      240

auuggcgacg auauaaaccg acguuacgac uccgaauuuc agacgauguu gcagcauuua      300

cagccaaccg cugagaaugc auaugaguac uuuacaaaga ucgccacuuc ucuguucgaa      360

ucggguauua acugggggag agucguggcu cuacucggau uuggcuauag gcuggcccuu      420

cacguuuacc aacauggccu gaccggguuc uugggacagg ugacacgguu ugucguggau      480

uucaugcucc accauuguau cgcgcgcugg auugcacaga gagguggcug gguagccgcu      540

cugaaucugg ggaacggacc cauccucaau guuuuagugg uccugggcgu ggugcuuuug      600

ggucaauuug ucguuaggcg guucuuuaaa ucauga                                636


<210>  6934
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bak__Homo_sapiens__AAA74466

<400>  6934
auggccagcg gccagggccc cggccccccc agacaggagu gcggcgagcc cgcccugccc       60

agcgccagcg aggagcaggu ggcccaggac accgaggagg uguucagaag cuacguguuc      120

uacagacacc agcaggagca ggaggccgag ggcguggccg cccccgccga ccccgagaug      180

gugacccugc cccugcagcc cagcagcacc augggccagg ugggcagaca gcuggccauc      240

aucggcgacg acaucaacag aagauacgac agcgaguucc agaccaugcu gcagcaccug      300

cagcccaccg ccgagaacgc cuacgaguac uucaccaaga ucgccaccag ccuguucgag      360

agcggcauca acuggggcag agugguggcc cugcugggcu ucggcuacag acuggcccug      420

cacguguacc agcacggccu gaccggcuuc cugggccagg ugaccagauu cgugguggac      480

uucaugcugc accacugcau cgccagaugg aucgcccaga gaggcggcug gguggccgcc      540

cugaaccugg gcaacggccc cauccugaac gugcuggugg ugcugggcgu ggugcugcug      600

ggccaguucg uggugagaag auucuucaag agcuga                                636


<210>  6935
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bak__Homo_sapiens__AAA74466

<400>  6935
auggccagcg gccaggggcc cggaccuccg agacaagagu gcggcgaacc cgcucugccu       60

uccgccucug aggaacaggu ggcgcaggac accgaggaag ucuuccggag cuacguuuuc      120

uaucgccacc agcaagagca ggaggcugaa gggguggccg cccccgcuga uccugagaug      180

gugacacucc cccugcagcc uuccucuacg augggacagg ucggcagaca acuugccauc      240

auuggggacg auaucaaccg gcgcuacgac agcgaauuuc agaccaugcu gcagcaucuc      300

cagccgacag cugagaaugc cuaugaguac uuuaccaaga uugcgacauc ccuguucgaa      360

ucuggaauca acuggggcag agugguugcc cuucugggcu uuggguaucg gcucgcucug      420

cacguguacc aacauggacu gaccggcuuc cucgggcagg ucacacgcuu ugugguugau      480

uucaugcugc accauuguau ugccagaugg aucgcucagc ggggaggcug gguggccgcg      540

cuuaaucugg ggaacggacc cauccucaau guccuggugg ugcuuggcgu cguucugcuc      600

ggccaauuug uggugcgcag auucuuuaaa agcuga                                636


<210>  6936
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bak__Homo_sapiens__AAA74466

<400>  6936
auggcaucag gacaaggacc aggaccacca agacaagaau guggagaacc agcacuacca       60

ucagcaagcg aagaacaagu agcacaagau acagaagaag uauucagaag uuacguauuu      120

uacagacacc aacaagaaca agaagcagaa ggaguagcag caccagcaga cccagaaaug      180

guaacacucc cacuacaacc aucaaguaca augggucaag uaggcagaca auuagcaaua      240

auaggagacg acauaaauag aagauacgau agcgaauucc aaacaauguu acaacacuua      300

caaccaacag cggaaaaugc auaugaauau uucacaaaaa uagcaacaag uuuauucgaa      360

agugguauaa auuggggaag aguaguagca uuauuaggcu ucggauauag auuagcauua      420

cacguauacc aacacggacu aacaggauuu uuaggacaag uaacuagauu cguaguagau      480

uuuauguuac aucacugcau agcuagaugg auagcacaaa gaggaggaug gguagcagca      540

cuaaauuuag gaaacggacc aauacuaaau guauuaguag uauuaggagu aguauuauua      600

ggacaauucg uaguaagaag auuuuuuaaa agcuaa                                636


<210>  6937
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bak__Homo_sapiens__Q8NFF3

<400>  6937

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Pro Ser Ser 
        35                  40                  45              


Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile Ile Gly Asp Asp Ile 
    50                  55                  60                  


Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met Leu Gln His Leu Gln 
65                  70                  75                  80  


Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr Lys Ile Ala Thr Ser 
                85                  90                  95      


Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val Val Ala Leu Leu Gly 
            100                 105                 110         


Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln His Gly Leu Thr Gly 
        115                 120                 125             


Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp Phe Met Leu His His 
    130                 135                 140                 


Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly Trp Val Ala Ala Leu 
145                 150                 155                 160 


Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu Val Val Leu Gly Val 
                165                 170                 175     


Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe Phe Lys Ser 
            180                 185                 190 


<210>  6938
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bak__Homo_sapiens__AAM74949

<400>  6938
auggcuucgg ggcaaggccc agguccuccc aggcaggagu guggagagcc ugcccugccc       60

ucugcuucug aggagcaggu agcccaggac acagaggagg uuuuccgcag cuacguuuuu      120

uaccgccauc agcaaccuag cagcaccaug gggcaggugg gacggcagcu cgccaucauc      180

ggggacgaca ucaaccgacg cuaugacuca gaguuccaga ccauguugca gcaccugcag      240

cccacggcag agaaugccua ugaguacuuc accaagauug ccaccagccu guuugagagu      300

ggcaucaauu ggggccgugu gguggcucuu cugggcuucg gcuaccgucu ggcccuacac      360

gucuaccagc auggccugac uggcuuccua ggccagguga cccgcuucgu ggucgacuuc      420

augcugcauc acugcauugc ccgguggauu gcacagaggg guggcugggu ggcagcccug      480

aacuugggca auggucccau ccugaacgug cuggugguuc uggguguggu ucuguugggc      540

caguuugugg uacgaagauu cuucaaauca uga                                   573


<210>  6939
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bak__Homo_sapiens__AAM74949

<400>  6939
auggccagcg gccaggggcc cggcccgccc cgccaggagu gcggggagcc cgcccugccc       60

uccgcgagcg aggagcaggu cgcccaggac accgaggagg uguuccgguc cuacguguuc      120

uaccgccacc agcagccgag cuccaccaug ggccaggugg ggcggcagcu cgccaucauc      180

ggcgacgaca ucaaccgccg guacgacagc gaguuccaga cgaugcugca gcaccuccag      240

cccaccgccg agaacgccua cgaguacuuc accaagaucg cgaccucccu guucgagagc      300

ggcaucaacu gggggcgcgu cguggcccug cugggcuucg gguaccggcu cgcccugcac      360

guguaccagc acggccugac gggguuccuc ggccagguca cccgcuucgu gguggacuuc      420

augcugcacc acugcaucgc ccgguggauc gcgcagcgcg gcgggugggu cgccgcccug      480

aaccucggca acgggcccau ccugaacgug cugguggucc ucggcguggu gcugcugggc      540

caguucgucg ugcggcgcuu cuucaagucc uga                                   573


<210>  6940
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bak__Homo_sapiens__AAM74949

<400>  6940
auggccuccg gccagggccc cggccccccc cgccaggagu gcggcgagcc cgcccucccc       60

uccgccuccg aggagcaggu cgcccaggac accgaggagg ucuuccgcuc cuacgucuuc      120

uaccgccacc agcagcccuc cuccaccaug ggccaggucg gccgccagcu cgccaucauc      180

ggcgacgaca ucaaccgccg cuacgacucc gaguuccaga ccaugcucca gcaccuccag      240

cccaccgccg agaacgccua cgaguacuuc accaagaucg ccaccucccu cuucgagucc      300

ggcaucaacu ggggccgcgu cgucgcccuc cucggcuucg gcuaccgccu cgcccuccac      360

gucuaccagc acggccucac cggcuuccuc ggccagguca cccgcuucgu cgucgacuuc      420

augcuccacc acugcaucgc ccgcuggauc gcccagcgcg gcggcugggu cgccgcccuc      480

aaccucggca acggccccau ccucaacguc cucgucgucc ucggcgucgu ccuccucggc      540

caguucgucg uccgccgcuu cuucaagucc uga                                   573


<210>  6941
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bak__Homo_sapiens__AAM74949

<400>  6941
auggccagcg gccaggggcc cggaccucca agacaagagu gcggugaacc ggcucugccc       60

uccgcaucug aggaacaggu ggcccaggac accgaggaag ucuucagguc auacguguuu      120

uaucggcacc agcaaccuag uagcacaaug ggccaggugg ggcgccagcu cgcgaucauu      180

ggagaugaca uaaaccgacg uuacgauucc gaguuccaga cuaugcuuca acaucugcag      240

ccaacggcug agaaugccua ugaauacuuu accaagaucg caacaucuuu guucgagucg      300

ggcauuaacu gggguagagu aguggccuua cugggguuug gauauaggcu agcucuccac      360

gucuaccagc auggccugac uggcuuccuu gggcagguua cccgguuugu uguggacuuc      420

augcugcacc auuguaucgc acgcuggauu gcccaaagag gagguugggu cgcugccuug      480

aaucucggca acgggcccau ccugaaugug cugguaguuc ucggaguggu cuuacugggc      540

caguuugugg ugaggcgguu cuuuaaauca uga                                   573


<210>  6942
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bak__Homo_sapiens__AAM74949

<400>  6942
auggccagcg gccagggccc cggccccccc agacaggagu gcggcgagcc cgcccugccc       60

agcgccagcg aggagcaggu ggcccaggac accgaggagg uguucagaag cuacguguuc      120

uacagacacc agcagcccag cagcaccaug ggccaggugg gcagacagcu ggccaucauc      180

ggcgacgaca ucaacagaag auacgacagc gaguuccaga ccaugcugca gcaccugcag      240

cccaccgccg agaacgccua cgaguacuuc accaagaucg ccaccagccu guucgagagc      300

ggcaucaacu ggggcagagu gguggcccug cugggcuucg gcuacagacu ggcccugcac      360

guguaccagc acggccugac cggcuuccug ggccagguga ccagauucgu gguggacuuc      420

augcugcacc acugcaucgc cagauggauc gcccagagag gcggcugggu ggccgcccug      480

aaccugggca acggccccau ccugaacgug cugguggugc ugggcguggu gcugcugggc      540

caguucgugg ugagaagauu cuucaagagc uga                                   573


<210>  6943
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bak__Homo_sapiens__AAM74949

<400>  6943
auggccagcg gccaggggcc cggaccuccg agacaagagu gcggcgaacc cgcucugccu       60

uccgccucug aggaacaggu ggcgcaggac accgaggaag ucuuccggag cuacguguuu      120

uaucgccacc agcaacccuc cucuacaaug gggcagguug gaagacagcu cgcuaucauu      180

ggcgaugaca ucaaccggcg cuacgauagc gaguuccaga cgaugcugca acaucuucag      240

ccuaccgccg agaaugccua ugaauacuuu acaaagauug cuaccucccu guucgagucu      300

gggaucaacu ggggaagagu ggucgcccuc cugggcuuug gcuaucggcu ugcucugcac      360

guguaccagc augggcucac aggauuccug ggccagguua cccgcuuugu ggucgacuuc      420

augcugcacc auuguauugc cagauggauc gcgcaacgcg ggggaugggu ggccgcucuc      480

aaucugggca acgggcccau ccuuaauguu cugguggucc ucggaguggu gcugcuuggc      540

caguuugucg uucggagauu cuuuaaaagc uga                                   573


<210>  6944
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bak__Homo_sapiens__AAM74949

<400>  6944
auggcaucag gucaaggacc aggaccacca agacaagaau guggagaacc agcauuacca       60

agugcuucag aagaacaagu agcacaagau acagaagaag uauuuagauc auauguauuu      120

uauagacacc aacaaccauc aucaacaaug ggacaaguag gaagacaauu agcaauaaua      180

ggagacgaua uaaauagaag auaugauuca gaauuucaaa caauguuaca acauuuacaa      240

ccaacagcag aaaaugcaua ugaauauuuc acaaaaauag caacaucauu auuugaauca      300

ggaauaaauu ggggaagagu aguagcuuua uuaggauucg gauaucgauu agcccuacau      360

guauaucaac auggauuaac aggauuuuua ggacaaguua caagauuugu aguugauuuu      420

auguuacauc auuguauagc uagauggaua gcacaaagag gaggaugggu agcagcacua      480

aaucuaggaa auggaccaau acuaaaugua uuaguaguau uaggaguagu acuauuagga      540

caauuuguag uaagaagauu uuuuaaauca uaa                                   573


<210>  6945
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__A0A0C4MVT1

<400>  6945

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Val Ser Ser Arg Ile 
1               5                   10                  15      


Glu Gln Gly Glu Trp Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp Pro 
            20                  25                  30          


Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys Arg 
        35                  40                  45              


Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile Ala 
    50                  55                  60                  


Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
65                  70                  75                  80  


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
                85                  90                  95      


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys Val 
            100                 105                 110         


Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu Arg 
        115                 120                 125             


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Gly Leu Pro 
    130                 135                 140                 


Leu Ala Glu Ser Leu Lys Arg Leu Met Ser Leu Ser Pro Gly Arg Pro 
145                 150                 155                 160 


Pro Leu Leu Leu Trp Asp Ala His Val Ala Asp Arg Asp His Leu Cys 
                165                 170                 175     


Gly Gly Ser Ala His Arg Leu Thr His His Leu Glu Glu Asp Gly Leu 
            180                 185                 190         


Arg Pro Pro Ala Ala Leu Asp Cys Val Phe Pro Pro 
        195                 200                 


<210>  6946
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__AIO10780

<400>  6946
auggacgggu ccggggagca gcccagaggc gggguuucau ccaggaucga gcagggcgaa       60

uggggggggg aggcacccga gcuggcccug gacccggugc cucaggaugc guccaccaag      120

aagcugagcg agugucucaa gcgcaucggg gacgaacugg acaguaacau ggagcugcag      180

aggaugauug ccgccgugga cacagacucc ccccgagagg ucuuuuuccg aguggcagcu      240

gacauguuuu cugacggcaa cuucaacugg ggccggguug ucgcccuuuu cuacuuugcc      300

agcaaacugg ugcucaaggc ccugugcacc aaggugccgg aacugaucag aaccaucaug      360

ggcuggacau uggacuuccu ccgggagcgg cuguugggcu ggauccaaga ccaggguggu      420

ugggggcugc cccuggccga gucacugaag cgacugaugu cccugucucc aggacggccu      480

ccucuccuac uuugggacgc ccacguggca gaccgugacc aucuuugugg cgggagugcu      540

caccgccuca cucaccaucu ggaagaagau gggcugaggc ccccagcugc cuuggacugu      600

guuuuuccuc cauaa                                                       615


<210>  6947
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__AIO10780

<400>  6947
auggacggca gcggggagca gccccgcggc ggggugucca gccggaucga gcagggcgag       60

uggggcgggg aggcccccga gcuggcccuc gaccccgucc cccaggacgc guccaccaag      120

aagcugagcg agugccugaa gcgcaucggc gacgagcucg acuccaacau ggagcugcag      180

cggaugaucg ccgccgugga caccgacagc ccccgcgagg uguucuuccg ggucgccgcc      240

gacauguucu ccgacgggaa cuucaacugg ggccgcgugg uggcgcuguu cuacuucgcc      300

agcaagcucg uccugaaggc ccugugcacg aaggugccgg agcucauccg gaccaucaug      360

ggguggaccc uggacuuccu gcgcgagcgg cuccugggcu ggauccagga ccagggcggg      420

uggggccugc cccucgccga gucccugaag cgccugauga gccucucccc cgggcggccc      480

ccgcugcugc ucugggacgc gcacguggcc gaccgcgacc accugugcgg cgggagcgcc      540

caccggcuga cccaccaccu cgaggaggac ggccugcgcc cgcccgccgc ccuggacugc      600

gucuucccgc ccuga                                                       615


<210>  6948
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__AIO10780

<400>  6948
auggacggcu ccggcgagca gccccgcggc ggcgucuccu cccgcaucga gcagggcgag       60

uggggcggcg aggcccccga gcucgcccuc gaccccgucc cccaggacgc cuccaccaag      120

aagcucuccg agugccucaa gcgcaucggc gacgagcucg acuccaacau ggagcuccag      180

cgcaugaucg ccgccgucga caccgacucc ccccgcgagg ucuucuuccg cgucgccgcc      240

gacauguucu ccgacggcaa cuucaacugg ggccgcgucg ucgcccucuu cuacuucgcc      300

uccaagcucg uccucaaggc ccucugcacc aagguccccg agcucauccg caccaucaug      360

ggcuggaccc ucgacuuccu ccgcgagcgc cuccucggcu ggauccagga ccagggcggc      420

uggggccucc cccucgccga gucccucaag cgccucaugu cccucucccc cggccgcccc      480

ccccuccucc ucugggacgc ccacgucgcc gaccgcgacc accucugcgg cggcuccgcc      540

caccgccuca cccaccaccu cgaggaggac ggccuccgcc cccccgccgc ccucgacugc      600

gucuuccccc ccuga                                                       615


<210>  6949
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__AIO10780

<400>  6949
auggacggca gcggggagca gcccagagga gguguguccu cuaggaucga acaaggcgag       60

uggggagggg aagccccuga gcuggcucuc gauccagucc cgcaggacgc aucaaccaag      120

aaacuuagug aaugccugaa gcggauuggc gaugaguugg acagcaacau ggaguuacag      180

cgcaugauag ccgcgguuga uacagacucu ccccgagaag uguucuuucg uguagcugcc      240

gauauguucu ccgacgguaa uuuuaacugg gggagagugg ucgcacuguu cuacuuugcc      300

ucgaagcuag ugcucaaagc ucuguguacu aaaguuccug agcuuaucag gacgauuaug      360

ggauggaccc uggauuucuu gcgggaacgc cuccugggcu ggauccagga ccaaggcggg      420

uggggacugc cacucgcaga gucauuaaag agacugauga gccuuagucc cgguaggccu      480

ccauugcugc uaugggaugc ccacguggcu gaccgggauc aucucugcgg cggguccgcc      540

caccgccuga cacaucaccu ugaggaagac ggacugcgac ccccugcggc auuggacugu      600

gucuuuccac cguga                                                       615


<210>  6950
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__AIO10780

<400>  6950
auggacggca gcggcgagca gcccagaggc ggcgugagca gcagaaucga gcagggcgag       60

uggggcggcg aggcccccga gcuggcccug gaccccgugc cccaggacgc cagcaccaag      120

aagcugagcg agugccugaa gagaaucggc gacgagcugg acagcaacau ggagcugcag      180

agaaugaucg ccgccgugga caccgacagc cccagagagg uguucuucag aguggccgcc      240

gacauguuca gcgacggcaa cuucaacugg ggcagagugg uggcccuguu cuacuucgcc      300

agcaagcugg ugcugaaggc ccugugcacc aaggugcccg agcugaucag aaccaucaug      360

ggcuggaccc uggacuuccu gagagagaga cugcugggcu ggauccagga ccagggcggc      420

uggggccugc cccuggccga gagccugaag agacugauga gccugagccc cggcagaccc      480

ccccugcugc ugugggacgc ccacguggcc gacagagacc accugugcgg cggcagcgcc      540

cacagacuga cccaccaccu ggaggaggac ggccugagac cccccgccgc ccuggacugc      600

guguuccccc ccuga                                                       615


<210>  6951
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__AIO10780

<400>  6951
auggacggca gcggggagca gccccgcgga ggcguguccu cucggaucga acaaggggag       60

uggggaggcg aagccccuga gcuggcucuc gauccggucc cccaggacgc cagcaccaag      120

aaacuguccg aaugccuuaa gcgcauuggg gaugagcugg acucuaacau ggagcuccag      180

agaaugaucg cggcuguuga uacagacagc ccucgggaag uguucuuucg cguggccgcc      240

gauauguucu ccgacggaaa uuuuaacugg ggcagagucg uggcucuguu cuacuuugcc      300

ucuaaacuug uucugaaggc ucucuguacg aaagugcccg agcugauucg gaccaucaug      360

ggcuggacac uggauuuccu ccgcgaaaga cugcuugggu ggauucagga ccaaggaggc      420

ugggggcugc cucucgccga gagccugaag cggcuuaugu cccugagccc cggacgcccu      480

ccgcuccugc ugugggaugc gcacgucgcc gacagagauc aucucugcgg cgggucugcu      540

caccggcuga cccaucaccu ugaggaagac ggacugagac ccccugccgc ucucgacugu      600

guguuucccc cuuga                                                       615


<210>  6952
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__AIO10780

<400>  6952
auggauggaa gcggagaaca accaagagga ggaguaagua guagaauaga acaaggagaa       60

uggggaggag aagcaccaga auuagcacua gauccaguac cacaagaugc aucaacgaaa      120

aaauuaucag aauguuuaaa aagaauagga gaugaauuag auaguaauau ggaauuacaa      180

agaaugauag cagcaguaga uacagauagu ccaagagaag uauuuuuuag aguagcagca      240

gauauguuua gugauggaaa uuuuaauugg ggaagaguag uagcauuauu uuauuuugca      300

aguaaauuag uauuaaaagc auuauguaca aaagugccag aauuaauaag aacaauaaug      360

ggauggacau uagauuuucu gagagaaaga uuauuaggau ggauucaaga ucaaggagga      420

uggggauuac cauuagcaga aagcuuaaaa agauuaauga guuuaagucc aggaagacca      480

ccauuacuau uaugggaugc acauguagca gauagagauc aucuaugugg aggaucagca      540

cauagauuaa cacaucauuu agaagaagau ggauuaagac caccagcagc auuagauugu      600

guauuuccac cauaa                                                       615


<210>  6953
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__A0A0C4MW46

<400>  6953

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Val Ser Ser Arg Ile 
1               5                   10                  15      


Glu Gln Gly Glu Trp Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp Pro 
            20                  25                  30          


Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys Arg 
        35                  40                  45              


Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile Ala 
    50                  55                  60                  


Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
65                  70                  75                  80  


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
                85                  90                  95      


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys Val 
            100                 105                 110         


Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu Arg 
        115                 120                 125             


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu 
    130                 135                 140                 


Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe Val 
145                 150                 155                 160 


Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
                165                 170                 175 


<210>  6954
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__AIO10778

<400>  6954
auggacgggu ccggggagca gcccagaggc gggguuucau ccaggaucga gcagggcgaa       60

uggggggggg aggcacccga gcuggcccug gacccggugc cucaggaugc guccaccaag      120

aagcugagcg agugucucaa gcgcaucggg gacgaacugg acaguaacau ggagcugcag      180

aggaugauug ccgccgugga cacagacucc ccccgagagg ucuuuuuccg aguggcagcu      240

gacauguuuu cugacggcaa cuucaacugg ggccggguug ucgcccuuuu cuacuuugcc      300

agcaaacugg ugcucaaggc ccugugcacc aaggugccgg aacugaucag aaccaucaug      360

ggcuggacau uggacuuccu ccgggagcgg cuguugggcu ggauccaaga ccaggguggu      420

ugggacggcc uccucuccua cuuugggacg cccacguggc agaccgugac caucuuugug      480

gcgggagugc ucaccgccuc acucaccauc uggaagaaga ugggcuga                   528


<210>  6955
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__AIO10778

<400>  6955
auggacggca gcggggagca gccccgcggc ggggugucca gccggaucga gcagggcgag       60

uggggcgggg aggccccgga gcuggcccuc gaccccgucc cccaggacgc guccaccaag      120

aagcugagcg agugccugaa gcgcaucggc gacgagcucg acuccaacau ggagcugcag      180

cggaugaucg ccgccgugga caccgacagc ccccgcgagg uguucuuccg ggucgccgcc      240

gacauguucu ccgacgggaa cuucaacugg ggccgcgugg uggcgcuguu cuacuucgcc      300

agcaagcucg uccugaaggc ccugugcacg aaggugccgg agcucauccg gaccaucaug      360

ggguggaccc uggacuuccu gcgcgagcgg cuccugggcu ggauccagga ccagggcggg      420

ugggacggcc ugcucuccua cuucgggacc cccacguggc agaccgugac caucuucguc      480

gccggcgugc ugaccgcgag ccugacgauc uggaagaaga ugggguga                   528


<210>  6956
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__AIO10778

<400>  6956
auggacggcu ccggcgagca gccccgcggc ggcgucuccu cccgcaucga gcagggcgag       60

uggggcggcg aggcccccga gcucgcccuc gaccccgucc cccaggacgc cuccaccaag      120

aagcucuccg agugccucaa gcgcaucggc gacgagcucg acuccaacau ggagcuccag      180

cgcaugaucg ccgccgucga caccgacucc ccccgcgagg ucuucuuccg cgucgccgcc      240

gacauguucu ccgacggcaa cuucaacugg ggccgcgucg ucgcccucuu cuacuucgcc      300

uccaagcucg uccucaaggc ccucugcacc aagguccccg agcucauccg caccaucaug      360

ggcuggaccc ucgacuuccu ccgcgagcgc cuccucggcu ggauccagga ccagggcggc      420

ugggacggcc uccucuccua cuucggcacc cccaccuggc agaccgucac caucuucguc      480

gccggcgucc ucaccgccuc ccucaccauc uggaagaaga ugggcuga                   528


<210>  6957
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__AIO10778

<400>  6957
auggacggca gcggggagca gcccagagga gguguguccu cuaggaucga acaaggcgag       60

uggggagggg aagccccuga gcuggcucuc gauccagucc cgcaggacgc aucaaccaag      120

aaacuuagug aaugccugaa gcggauuggc gaugaguugg acagcaacau ggaguuacag      180

cgcaugauag ccgcgguuga uacagacucu ccccgagaag uguucuuucg uguagcugcc      240

gauauguucu ccgacgguaa uuuuaacugg gggagagugg ucgcacuguu cuacuuugcc      300

ucgaagcuag ugcucaaagc ucuguguacu aaaguuccug agcuuaucag gacgauuaug      360

ggauggaccc uggauuucuu gcgggaacgc cuccugggcu ggauccagga ccaaggcggg      420

ugggauggac ugcucucaua uuuugguaca ccaacuuggc agaccgugac aauuuucguc      480

gcaggcgugu uaaccgccag ccugacuauc uggaagaaga ugggguga                   528


<210>  6958
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__AIO10778

<400>  6958
auggacggca gcggcgagca gcccagaggc ggcgugagca gcagaaucga gcagggcgag       60

uggggcggcg aggcccccga gcuggcccug gaccccgugc cccaggacgc cagcaccaag      120

aagcugagcg agugccugaa gagaaucggc gacgagcugg acagcaacau ggagcugcag      180

agaaugaucg ccgccgugga caccgacagc cccagagagg uguucuucag aguggccgcc      240

gacauguuca gcgacggcaa cuucaacugg ggcagagugg uggcccuguu cuacuucgcc      300

agcaagcugg ugcugaaggc ccugugcacc aaggugcccg agcugaucag aaccaucaug      360

ggcuggaccc uggacuuccu gagagagaga cugcugggcu ggauccagga ccagggcggc      420

ugggacggcc ugcugagcua cuucggcacc cccaccuggc agaccgugac caucuucgug      480

gccggcgugc ugaccgccag ccugaccauc uggaagaaga ugggcuga                   528


<210>  6959
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__AIO10778

<400>  6959
auggacggca gcggggagca gcccagagga ggcguguccu cucggaucga acaaggggag       60

uggggaggcg aagccccuga gcuggcucuc gauccggucc cccaggacgc cagcaccaag      120

aaacuguccg aaugccuuaa gcgcauuggg gaugagcugg acucuaacau ggagcuccag      180

agaaugaucg cggcuguuga uacagacagc ccucgggaag uguucuuucg cguggccgcc      240

gauauguucu ccgacggaaa uuuuaacugg ggcagagucg uggcucuguu cuacuuugcc      300

ucuaaacuug uucugaaggc ucucuguacg aaagugcccg agcugauucg gaccaucaug      360

ggcuggacac uggauuuccu ccgcgaaaga cugcuugggu ggauucagga ccaaggaggc      420

ugggaugggc ugcucagcua uuuuggaacc ccuacauggc agaccgucac aaucuucgug      480

gccggcguuc ugaccgcguc ccuuacgauc uggaagaaga ugggguga                   528


<210>  6960
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__AIO10778

<400>  6960
auggacggaa guggagaaca accaagagga ggaguaucaa guagaauaga acaaggagaa       60

uggggaggag aagcaccaga auuagcauua gauccaguac cacaagaugc aaguacaaaa      120

aaauuaagug aauguuuaaa aagaauagga gaugaacuag auaguaauau ggaauuacaa      180

agaaugauag cagcaguaga uacagauagu ccaagagaag uauuuuuuag aguagcagca      240

gauauguuua gugauggaaa uuuuaauugg ggaagaguag uagcauuauu uuauuuugca      300

aguaaacuag uauuaaaagc auuauguaca aaaguaccag aacuaauaag aacaauaaug      360

ggauggacau uagauuuuuu aagagaaaga uuguuaggau ggauacaaga ucaaggagga      420

ugggauggau uauuaaguua uuuuggaaca ccaacauggc aaacaguaac aauauuugua      480

gcaggaguau ugacagcaag uuuaacaaua uggaaaaaaa ugggauaa                   528


<210>  6961
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__A0A0C4MWS3

<400>  6961

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Phe His Pro Gly 
1               5                   10                  15      


Ser Ser Arg Ala Asn Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp Pro 
            20                  25                  30          


Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys Arg 
        35                  40                  45              


Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile Ala 
    50                  55                  60                  


Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
65                  70                  75                  80  


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
                85                  90                  95      


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys Val 
            100                 105                 110         


Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu Arg 
        115                 120                 125             


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Gly Leu Pro 
    130                 135                 140                 


Leu Ala Glu Ser Leu Lys Arg Leu Met Ser Leu Ser Pro Gly Arg Pro 
145                 150                 155                 160 


Pro Leu Leu Leu Trp Asp Ala His Val Ala Asp Arg Asp His Leu Cys 
                165                 170                 175     


Gly Gly Ser Ala His Arg Leu Thr His His Leu Glu Glu Asp Gly Leu 
            180                 185                 190         


Arg Pro Pro Ala Ala Leu Asp Cys Val Phe Pro Pro 
        195                 200                 


<210>  6962
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__AIO10779

<400>  6962
auggacgggu ccggggagca gcccagaggc gggggguuuc auccaggauc gagcagggcg       60

aauggggggg aggcacccga gcuggcccug gacccggugc cucaggaugc guccaccaag      120

aagcugagcg agugucucaa gcgcaucggg gacgaacugg acaguaacau ggagcugcag      180

aggaugauug ccgccgugga cacagacucc ccccgagagg ucuuuuuccg aguggcagcu      240

gacauguuuu cugacggcaa cuucaacugg ggccggguug ucgcccuuuu cuacuuugcc      300

agcaaacugg ugcucaaggc ccugugcacc aaggugccgg aacugaucag aaccaucaug      360

ggcuggacau uggacuuccu ccgggagcgg cuguugggcu ggauccaaga ccaggguggu      420

ugggggcugc cccuggccga gucacugaag cgacugaugu cccugucucc aggacggccu      480

ccucuccuac uuugggacgc ccacguggca gaccgugacc aucuuugugg cgggagugcu      540

caccgccuca cucaccaucu ggaagaagau gggcugaggc ccccagcugc cuuggacugu      600

guuuuuccuc cauaa                                                       615


<210>  6963
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__AIO10779

<400>  6963
auggacggca gcggggagca gccccgcggc gggggcuucc accccggguc cagccgggcc       60

aacggcggcg aggcccccga gcuggcgcuc gaccccgugc cccaggacgc cuccaccaag      120

aagcugagcg agugccugaa gcgcaucggg gacgagcucg acuccaacau ggagcugcag      180

cggaugaucg ccgccgucga caccgacagc ccgcgcgagg uguucuuccg gguggccgcg      240

gacauguucu ccgacggcaa cuucaacugg gggcgcgucg uggcccuguu cuacuucgcc      300

agcaagcucg ugcugaaggc ccugugcacg aagguccccg agcucauccg gaccaucaug      360

ggcuggaccc uggacuuccu gcgcgagcgg cuccuggggu ggauccagga ccagggcggc      420

ugggggcugc cccucgcgga gucccugaag cgccugauga gccucucccc cggccggccg      480

ccccugcugc ucugggacgc ccacguggcc gaccgcgacc accugugcgg gggcagcgcc      540

caccggcuga cccaccaccu cgaggaggac ggccugcgcc cgcccgccgc gcuggacugc      600

guguucccgc ccuga                                                       615


<210>  6964
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__AIO10779

<400>  6964
auggacggcu ccggcgagca gccccgcggc ggcggcuucc accccggcuc cucccgcgcc       60

aacggcggcg aggcccccga gcucgcccuc gaccccgucc cccaggacgc cuccaccaag      120

aagcucuccg agugccucaa gcgcaucggc gacgagcucg acuccaacau ggagcuccag      180

cgcaugaucg ccgccgucga caccgacucc ccccgcgagg ucuucuuccg cgucgccgcc      240

gacauguucu ccgacggcaa cuucaacugg ggccgcgucg ucgcccucuu cuacuucgcc      300

uccaagcucg uccucaaggc ccucugcacc aagguccccg agcucauccg caccaucaug      360

ggcuggaccc ucgacuuccu ccgcgagcgc cuccucggcu ggauccagga ccagggcggc      420

uggggccucc cccucgccga gucccucaag cgccucaugu cccucucccc cggccgcccc      480

ccccuccucc ucugggacgc ccacgucgcc gaccgcgacc accucugcgg cggcuccgcc      540

caccgccuca cccaccaccu cgaggaggac ggccuccgcc cccccgccgc ccucgacugc      600

gucuuccccc ccuga                                                       615


<210>  6965
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__AIO10779

<400>  6965
auggacggca gcggggagca gcccagagga gguggcuucc acccuggguc cucuagggcc       60

aacggaggcg aagcuccaga gcuggcacuc gauccggugc cccaggacgc cucaaccaag      120

aaacuuagug aaugccugaa gcggaucggu gaugaguugg acagcaauau ggaauuacag      180

cgcaugauug cggcugucga uacagacucc ccucgagagg uguuuuuccg uguugccgca      240

gauauguuuu cugacgggaa cuucaauugg ggaagaguag uggcccuguu uuacuucgcu      300

ucgaaauugg uccucaaggc acuguguacu aaagugccag agcuuauaag gacgaucaug      360

ggcuggaccc uggauuuucu acgggaacgc cuccugggcu ggauucagga ccaaggggga      420

uggggucugc cccucgccga gucauuaaag agacugauga gccuuagucc uggcaggcca      480

cccuugcugc uaugggaugc ucauguugcc gaccgggauc accucugcgg gggauccgcg      540

caucgccuga cacaccaucu ugaagaggac ggccugcgac cuccagcagc cuuggacugu      600

guguucccgc ccuga                                                       615


<210>  6966
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__AIO10779

<400>  6966
auggacggca gcggcgagca gcccagaggc ggcggcuucc accccggcag cagcagagcc       60

aacggcggcg aggcccccga gcuggcccug gaccccgugc cccaggacgc cagcaccaag      120

aagcugagcg agugccugaa gagaaucggc gacgagcugg acagcaacau ggagcugcag      180

agaaugaucg ccgccgugga caccgacagc cccagagagg uguucuucag aguggccgcc      240

gacauguuca gcgacggcaa cuucaacugg ggcagagugg uggcccuguu cuacuucgcc      300

agcaagcugg ugcugaaggc ccugugcacc aaggugcccg agcugaucag aaccaucaug      360

ggcuggaccc uggacuuccu gagagagaga cugcugggcu ggauccagga ccagggcggc      420

uggggccugc cccuggccga gagccugaag agacugauga gccugagccc cggcagaccc      480

ccccugcugc ugugggacgc ccacguggcc gacagagacc accugugcgg cggcagcgcc      540

cacagacuga cccaccaccu ggaggaggac ggccugagac cccccgccgc ccuggacugc      600

guguuccccc ccuga                                                       615


<210>  6967
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__AIO10779

<400>  6967
auggacggca gcggggagca gcccagagga ggcggguucc acccuggauc cucucgggcc       60

aacggcgggg aagcuccgga gcuggcccuc gaucccgugc cucaagacgc gagcaccaag      120

aaacuguccg aaugccuuaa gcgcaucgga gaugagcugg acucuaauau ggaacuccag      180

agaaugauug cugccgucga uacagacagc ccccgggagg uguuuuuccg cguugccgcu      240

gauauguuuu ccgacggcaa cuucaauugg ggcagagugg ucgcccuguu uuacuucgcu      300

ucuaaacuug ugcugaaggc ccucuguacg aaaguuccug agcugauccg gaccauuaug      360

ggguggacac uggauuuucu ccgcgaaaga cugcuuggau ggauccagga ccagggcggg      420

uggggacugc cccucgcgga gagccugaag cggcuuaugu cccugagccc uggccgcccg      480

ccccuccugc ugugggaugc ccauguggcu gacagagauc accucugcgg gggaucugcc      540

caucggcuga cccaccaucu ugaagaggac ggccugcgcc cucccgcugc ccucgacugu      600

gucuucccuc ccuga                                                       615


<210>  6968
<211>  615
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__AIO10779

<400>  6968
auggauggaa guggagaaca accaagagga ggaggauuuc auccaggauc aagcagagca       60

aauggaggag aagcaccaga acuagcguua gauccaguac cacaagaugc aaguacaaaa      120

aaauuaucag aauguuuaaa aagaauagga gaugaauuag auaguaauau ggaauuacaa      180

agaaugauag cagcaguaga uacagauagu ccaagagaag uauuuuuuag aguagcagca      240

gauauguuua gugauggaaa uuuuaauugg ggaagaguag uagcauuauu uuauuuugca      300

ucaaaauuag uauuaaaagc auuauguaca aaaguaccag aauuaauaag aacaauaaug      360

ggauggacac uagauuuuuu aagagaaaga uuacuagggu ggauacaaga ucaaggagga      420

uggggauuac cacuagcaga aaguuuaaaa agauuaauga guuuaagucc aggaagacca      480

ccauuauuac uaugggaugc acauguugca gacagagauc auuuaugugg aggaucagca      540

cauagauuaa cacaucaucu agaagaagau ggacuuagac caccagcagc auuagauugu      600

guuuuuccac cauaa                                                       615


<210>  6969
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__I6LPK7

<400>  6969

Met Ile Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg 
1               5                   10                  15      


Val Ala Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val 
            20                  25                  30          


Val Ala Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys 
        35                  40                  45              


Thr Lys Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp 
    50                  55                  60                  


Phe Leu Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp 
65                  70                  75                  80  


Val Arg Leu Leu Lys Pro Pro His Pro His His Arg Ala Leu Thr Thr 
                85                  90                  95      


Ala Pro Ala Pro Pro Ser Leu Pro Pro Ala Thr Pro Leu Gly Pro Trp 
            100                 105                 110         


Ala Phe Trp Ser Arg Ser Gln Trp Cys Pro Leu Pro Ile Phe Arg Ser 
        115                 120                 125             


Ser Asp Val Val Tyr Asn Ala Phe Ser Leu Arg Val 
    130                 135                 140 


<210>  6970
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__ADZ05507

<400>  6970
augauugccg ccguggacac agacuccccc cgagaggucu uuuuccgagu ggcagcugac       60

auguuuucug acggcaacuu caacuggggc cggguugucg cccuuuucua cuuugccagc      120

aaacuggugc ucaaggcccu gugcaccaag gugccggaac ugaucagaac caucaugggc      180

uggacauugg acuuccuccg ggagcggcug uugggcugga uccaagacca gggugguugg      240

gugagacucc ucaagccucc ucacccccac caccgcgccc ucaccaccgc cccugcccca      300

ccgucccugc cccccgccac uccucuggga cccugggccu ucuggagcag gucacagugg      360

ugcccucucc ccaucuucag aucaucagau guggucuaua augcguuuuc cuuacguguc      420

uga                                                                    423


<210>  6971
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__ADZ05507

<400>  6971
augaucgccg ccguggacac cgacagcccc cgcgaggucu ucuuccgggu ggcggccgac       60

auguucuccg acggcaacuu caacuggggg cgcguggucg cccuguucua cuucgccagc      120

aagcucgugc ugaaggcccu gugcaccaag gugccggagc ucauccggac gaucaugggc      180

uggacccugg acuuccugcg cgagcggcuc cuggggugga uccaggacca gggcgggugg      240

guccgccugc ucaagccgcc ccacccccac caccgggcgc ugaccaccgc ccccgccccg      300

cccucccugc cgcccgccac gccccucggc cccugggcgu ucuggagccg cucccagugg      360

ugcccccugc ccaucuuccg gagcuccgac gugguguaca acgccuucag ccugcgcguc      420

uga                                                                    423


<210>  6972
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__ADZ05507

<400>  6972
augaucgccg ccgucgacac cgacuccccc cgcgaggucu ucuuccgcgu cgccgccgac       60

auguucuccg acggcaacuu caacuggggc cgcgucgucg cccucuucua cuucgccucc      120

aagcucgucc ucaaggcccu cugcaccaag guccccgagc ucauccgcac caucaugggc      180

uggacccucg acuuccuccg cgagcgccuc cucggcugga uccaggacca gggcggcugg      240

guccgccucc ucaagccccc ccacccccac caccgcgccc ucaccaccgc ccccgccccc      300

cccucccucc cccccgccac cccccucggc cccugggccu ucuggucccg cucccagugg      360

ugcccccucc ccaucuuccg cuccuccgac gucgucuaca acgccuucuc ccuccgcguc      420

uga                                                                    423


<210>  6973
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__ADZ05507

<400>  6973
augaucgccg cuguggacac cgauagcccc agagaggucu ucuuuagggu ugcagccgac       60

auguucuccg auggcaacuu uaauuggggg cgggugguag cgcuguucua cuuugcuucu      120

aagcucgugc uuaaagcccu gugcacaaag gucccugaau ugauucgcac uauaauggga      180

uggacguuag acuuccugcg agagcgucua cucgguugga uccaggauca aggcgggugg      240

gugagacugc uuaaaccacc gcacccccau cacagggcac ugaccacagc cccugcucca      300

cccucauugc cuccagcaac uccccucgga ccuugggccu uuuggagucg gagccagugg      360

uguccacugc cgauuuuccg cuccucugac guuguguaua acgcuuuuuc gcugagaguc      420

uga                                                                    423


<210>  6974
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__ADZ05507

<400>  6974
augaucgccg ccguggacac cgacagcccc agagaggugu ucuucagagu ggccgccgac       60

auguucagcg acggcaacuu caacuggggc agaguggugg cccuguucua cuucgccagc      120

aagcuggugc ugaaggcccu gugcaccaag gugcccgagc ugaucagaac caucaugggc      180

uggacccugg acuuccugag agagagacug cugggcugga uccaggacca gggcggcugg      240

gugagacugc ugaagccccc ccacccccac cacagagccc ugaccaccgc ccccgccccc      300

cccagccugc cccccgccac cccccugggc cccugggccu ucuggagcag aagccagugg      360

ugcccccugc ccaucuucag aagcagcgac gugguguaca acgccuucag ccugagagug      420

uga                                                                    423


<210>  6975
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__ADZ05507

<400>  6975
augaucgccg cuguggacac cgauagcccc agagaggucu ucuuucgggu ugccgcggac       60

auguucuccg auggcaacuu uaauuggggg cgcguggugg cucuguucua cuuugccucu      120

aagcucgucc ugaaagcccu uugcacaaag gugccugaac ugauuagaac gaucauggga      180

uggacccucg acuuccugcg ggagcgccuu cugggcugga uucaggauca agggggaugg      240

guuagacucc ugaaaccgcc ccacccucau caccgggcuc ugacaaccgc ccccgcuccu      300

cccagccucc cuccggccac accccugggc ccuugggcgu uuuggucccg cucucagugg      360

uguccccuuc cuaucuucag aagcuccgac guggucuaua acgccuuuuc ucugcgggug      420

uga                                                                    423


<210>  6976
<211>  423
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__ADZ05507

<400>  6976
augauagcag caguagauac agauucacca agagaaguau uuuucagagu agcagcagau       60

auguuuucag auggaaauuu caauugggga agaguaguag cacuauuuua cuuugcauca      120

aaauuaguau uaaaagcauu auguacaaaa guaccagaau uaauaagaac aauaauggga      180

uggacacuag auuucuuaag agaaagauua cuaggaugga uacaagauca aggaggaugg      240

guaagacuau uaaaaccacc acauccacau caccgagcau uaacaacagc accagcacca      300

ccaucacuac caccagcaac accacuagga ccaugggcau uuuggucaag aagucaaugg      360

ugcccacuac caauauuuag aucaucagau guaguauaca augcauuuuc auuaagagua      420

uaa                                                                    423


<210>  6977
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__K4JQN1

<400>  6977

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Phe His Pro Gly 
1               5                   10                  15      


Ser Ser Arg Ala Asn Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp Pro 
            20                  25                  30          


Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys Arg 
        35                  40                  45              


Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile Ala 
    50                  55                  60                  


Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
65                  70                  75                  80  


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
                85                  90                  95      


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys Val 
            100                 105                 110         


Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu Arg 
        115                 120                 125             


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu 
    130                 135                 140                 


Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe Val 
145                 150                 155                 160 


Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
                165                 170                 175 


<210>  6978
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__AFU81108

<400>  6978
auggacgggu ccggggagca gcccagaggc gggggguuuc auccaggauc gagcagggcg       60

aauggggggg aggcacccga gcuggcccug gacccggugc cucaggaugc guccaccaag      120

aagcugagcg agugucucaa gcgcaucggg gacgaacugg acaguaacau ggagcugcag      180

aggaugauug ccgccgugga cacagacucc ccccgagagg ucuuuuuccg aguggcagcu      240

gacauguuuu cugacggcaa cuucaacugg ggccggguug ucgcccuuuu cuacuuugcc      300

agcaaacugg ugcucaaggc ccugugcacc aaggugccgg aacugaucag aaccaucaug      360

ggcuggacau uggacuuccu ccgggagcgg cuguugggcu ggauccaaga ccaggguggu      420

ugggacggcc uccucuccua cuuugggacg cccacguggc agaccgugac caucuuugug      480

gcgggagugc ucaccgccuc acucaccauc uggaagaaga ugggcuga                   528


<210>  6979
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__AFU81108

<400>  6979
auggacggca gcggggagca gccccgcggc gggggcuucc acccgggguc cagccgggcc       60

aacggcggcg aggcccccga gcuggcgcuc gaccccgugc cccaggacgc cuccaccaag      120

aagcugagcg agugccugaa gcgcaucggg gacgagcucg acuccaacau ggagcugcag      180

cggaugaucg ccgccgucga caccgacagc ccgcgcgagg uguucuuccg gguggccgcg      240

gacauguucu ccgacggcaa cuucaacugg gggcgcgucg uggcccuguu cuacuucgcc      300

agcaagcucg ugcugaaggc ccugugcacg aagguccccg agcucauccg gaccaucaug      360

ggcuggaccc uggacuuccu gcgcgagcgg cuccuggggu ggauccagga ccagggcggc      420

ugggacgggc ugcucuccua cuucggcacc cccacguggc agaccgugac caucuucgug      480

gcgggggucc ugaccgccag ccugacgauc uggaagaaga ugggcuga                   528


<210>  6980
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__AFU81108

<400>  6980
auggacggcu ccggcgagca gccccgcggc ggcggcuucc accccggcuc cucccgcgcc       60

aacggcggcg aggcccccga gcucgcccuc gaccccgucc cccaggacgc cuccaccaag      120

aagcucuccg agugccucaa gcgcaucggc gacgagcucg acuccaacau ggagcuccag      180

cgcaugaucg ccgccgucga caccgacucc ccccgcgagg ucuucuuccg cgucgccgcc      240

gacauguucu ccgacggcaa cuucaacugg ggccgcgucg ucgcccucuu cuacuucgcc      300

uccaagcucg uccucaaggc ccucugcacc aagguccccg agcucauccg caccaucaug      360

ggcuggaccc ucgacuuccu ccgcgagcgc cuccucggcu ggauccagga ccagggcggc      420

ugggacggcc uccucuccua cuucggcacc cccaccuggc agaccgucac caucuucguc      480

gccggcgucc ucaccgccuc ccucaccauc uggaagaaga ugggcuga                   528


<210>  6981
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__AFU81108

<400>  6981
auggacggca gcggggagca gcccagagga gguggcuucc acccuggguc cucuagggcc       60

aacggaggcg aagcuccaga gcuggcacuc gauccggugc cccaagacgc cucaaccaag      120

aaacuuagug aaugccugaa gcggaucggu gaugaguugg acagcaauau ggaauuacag      180

cgcaugauug cggcugucga uacagacucc ccucgagagg uguuuuuccg uguugccgca      240

gauauguuuu cugacgggaa cuucaauugg ggaagaguag uggcccuguu uuacuucgcu      300

ucgaaauugg uccucaaggc acuguguacu aaagugccag agcuuauaag gacgaucaug      360

ggcuggaccc uggauuuucu acgggaacgc cuccugggcu ggauucagga ccaaggggga      420

ugggaugguc ugcucucaua uuucggcaca cccacuuggc agaccguuac aaucuuugug      480

gccggggucu uaaccgcuag ccugacuauu uggaagaaga ugggauga                   528


<210>  6982
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__AFU81108

<400>  6982
auggacggca gcggcgagca gcccagaggc ggcggcuucc accccggcag cagcagagcc       60

aacggcggcg aggcccccga gcuggcccug gaccccgugc cccaggacgc cagcaccaag      120

aagcugagcg agugccugaa gagaaucggc gacgagcugg acagcaacau ggagcugcag      180

agaaugaucg ccgccgugga caccgacagc cccagagagg uguucuucag aguggccgcc      240

gacauguuca gcgacggcaa cuucaacugg ggcagagugg uggcccuguu cuacuucgcc      300

agcaagcugg ugcugaaggc ccugugcacc aaggugcccg agcugaucag aaccaucaug      360

ggcuggaccc uggacuuccu gagagagaga cugcugggcu ggauccagga ccagggcggc      420

ugggacggcc ugcugagcua cuucggcacc cccaccuggc agaccgugac caucuucgug      480

gccggcgugc ugaccgccag ccugaccauc uggaagaaga ugggcuga                   528


<210>  6983
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__AFU81108

<400>  6983
auggacggca gcggggagca gcccagagga ggcggguucc acccuggauc cucucgggcc       60

aacggcgggg aagcuccgga gcuggcccuc gaucccgugc cucaagacgc gagcaccaag      120

aaacuguccg aaugccuuaa gcgcaucgga gaugagcugg acucuaauau ggaacuccag      180

agaaugauug cugccgucga uacagacagc ccccgggagg uguuuuuccg cguugccgcu      240

gauauguuuu ccgacggcaa cuucaauugg ggcagagugg ucgcccuguu uuacuucgcu      300

ucuaaacuug ugcugaaggc ccucuguacg aaaguuccug agcugauccg gaccauuaug      360

ggguggacac uggauuuucu ccgcgaaaga cugcuuggau ggauccagga ccagggcggg      420

ugggauggac ugcucagcua uuucggcacc cccacauggc aaaccgugac aauuuuuguc      480

gcgggggugc ugaccgccuc ccuuacgauc uggaagaaga ugggauga                   528


<210>  6984
<211>  528
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__AFU81108

<400>  6984
auggauggaa guggggaaca accaagagga ggaggauuuc auccaggaag uaguagagca       60

aauggaggag aagcuccaga auuagcauua gauccaguac cacaagaugc aaguacaaaa      120

aaauuaagug aauguuuaaa aagaauagga gaugaauuag auaguaauau ggaauuacaa      180

agaaugauag cagcaguaga uacagauuca ccaagagaag uauuuuuuag aguagcagca      240

gauauguuua gugauggaaa uuuuaauugg gguagaguag uagcauuauu uuauuuugca      300

aguaaauuag uacuaaaagc auuauguaca aaaguaccag aauuaauaag aacaauaaug      360

ggauggacau uagauuuuuu aagggaaaga uuauuaggau ggauacaaga ucaaggagga      420

ugggauggau uauuaagcua uuuuggaaca ccaacauggc aaacaguaac aauauuugua      480

gcaggaguau uaacagcaag uuuaacaaua uggaaaaaaa ugggauaa                   528


<210>  6985
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__Q07812

<400>  6985

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         






<210>  6986
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bax__Homo_sapiens__AAA03619

<400>  6986
auggacgggu ccggggagca gcccagaggc ggggggccca ccagcucuga gcagaucaug       60

aagacagggg cccuuuugcu ucaggguuuc auccaggauc gagcagggcg aauggggggg      120

gaggcacccg agcuggcccu ggacccggug ccucaggaug cguccaccaa gaagcugagc      180

gagugucuca agcgcaucgg ggacgaacug gacaguaaca uggagcugca gaggaugauu      240

gccgccgugg acacagacuc cccccgagag gucuuuuucc gaguggcagc ugacauguuu      300

ucugacggca acuucaacug gggccggguu gucgcccuuu ucuacuuugc cagcaaacug      360

gugcucaagg cccugugcac caaggugccg gaacugauca gaaccaucau gggcuggaca      420

uuggacuucc uccgggagcg gcuguugggc uggauccaag accagggugg uugggacggc      480

cuccucuccu acuuugggac gcccacgugg cagaccguga ccaucuuugu ggcgggagug      540

cucaccgccu cgcucaccau cuggaagaag augggcuga                             579


<210>  6987
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bax__Homo_sapiens__AAA03619

<400>  6987
auggacggca gcggggagca gccccgcggc gggggcccga ccuccagcga gcagaucaug       60

aagaccgggg cccugcuccu gcagggcuuc auccaggacc gggccggccg caugggcggg      120

gaggcgcccg agcuggcccu cgaccccgug ccccaggacg ccuccacgaa gaagcugagc      180

gagugccuga agcggaucgg ggacgagcuc gacuccaaca uggagcugca gcgcaugauc      240

gccgccgucg acaccgacag cccgcgggag guguucuucc gcguggcggc cgacauguuc      300

uccgacggca acuucaacug ggggcggguc guggcccugu ucuacuucgc cagcaagcuc      360

gugcugaagg cgcugugcac caaggucccc gagcucaucc gcaccaucau gggcuggacg      420

cuggacuucc ugcgggagcg ccuccugggc uggauccagg accagggcgg gugggacggg      480

cugcucuccu acuucggcac ccccaccugg cagaccguga cgaucuucgu ggccggcguc      540

cugaccgcca gccugaccau cuggaagaag augggguga                             579


<210>  6988
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bax__Homo_sapiens__AAA03619

<400>  6988
auggacggcu ccggcgagca gccccgcggc ggcggcccca ccuccuccga gcagaucaug       60

aagaccggcg cccuccuccu ccagggcuuc auccaggacc gcgccggccg caugggcggc      120

gaggcccccg agcucgcccu cgaccccguc ccccaggacg ccuccaccaa gaagcucucc      180

gagugccuca agcgcaucgg cgacgagcuc gacuccaaca uggagcucca gcgcaugauc      240

gccgccgucg acaccgacuc cccccgcgag gucuucuucc gcgucgccgc cgacauguuc      300

uccgacggca acuucaacug gggccgcguc gucgcccucu ucuacuucgc cuccaagcuc      360

guccucaagg cccucugcac caaggucccc gagcucaucc gcaccaucau gggcuggacc      420

cucgacuucc uccgcgagcg ccuccucggc uggauccagg accagggcgg cugggacggc      480

cuccucuccu acuucggcac ccccaccugg cagaccguca ccaucuucgu cgccggcguc      540

cucaccgccu cccucaccau cuggaagaag augggcuga                             579


<210>  6989
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bax__Homo_sapiens__AAA03619

<400>  6989
auggacggca gcggggagca gcccagagga gguggcccua ccuccucuga acaaaucaug       60

aagacagggg cccugcuccu ucagggauuc auucaggaua gggcuggccg gauggguggg      120

gaggcaccag aacuggccuu ggacccggug ccccaggaug cgucaacuaa aaaguuaagu      180

gagugccuga aacgcauagg agacgaacua gauagcaaca uggagcucca acgaaugauc      240

gcugccgucg acacggauuc cccucgugag guguuuuuca gaguugcagc cgacauguuu      300

ucugauggca auuucaacug gggcagggua guggcucugu uuuacuucgc aucgaaacuu      360

guccugaagg ccuuguguac caaggugcca gaacucauuc ggacaaucau gggguggacu      420

cuggacuuuc ugcgcgagag acucuuagga uggauucagg aucagggugg cugggacggg      480

cugcuuucau auuucggaac ccccacaugg cagaccguua cuaucuuugu ggcuggcguc      540

uugacagcca gccugaccau auggaagaaa auggguuga                             579


<210>  6990
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bax__Homo_sapiens__AAA03619

<400>  6990
auggacggca gcggcgagca gcccagaggc ggcggcccca ccagcagcga gcagaucaug       60

aagaccggcg cccugcugcu gcagggcuuc auccaggaca gagccggcag aaugggcggc      120

gaggcccccg agcuggcccu ggaccccgug ccccaggacg ccagcaccaa gaagcugagc      180

gagugccuga agagaaucgg cgacgagcug gacagcaaca uggagcugca gagaaugauc      240

gccgccgugg acaccgacag ccccagagag guguucuuca gaguggccgc cgacauguuc      300

agcgacggca acuucaacug gggcagagug guggcccugu ucuacuucgc cagcaagcug      360

gugcugaagg cccugugcac caaggugccc gagcugauca gaaccaucau gggcuggacc      420

cuggacuucc ugagagagag acugcugggc uggauccagg accagggcgg cugggacggc      480

cugcugagcu acuucggcac ccccaccugg cagaccguga ccaucuucgu ggccggcgug      540

cugaccgcca gccugaccau cuggaagaag augggcuga                             579


<210>  6991
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bax__Homo_sapiens__AAA03619

<400>  6991
auggacggca gcggggagca gcccagagga ggcgggccua ccuccucuga acaaaucaug       60

aagacaggag cccugcuccu gcagggcuuc auucaggauc gggcugggcg caugggaggc      120

gaggccccgg aacuugcgcu ggaccccgug ccucaggaug cuagcacgaa aaagcucucc      180

gagugccuga aaagaaucgg cgacgaacuu gauucuaaca uggagcugca acggaugauu      240

gccgccgucg acaccgauag cccccgcgag guguuuuuca gaguugcugc cgacauguuu      300

uccgauggga auuucaacug gggacgggug gucgcucucu uuuacuucgc cucuaagcug      360

gugcugaaag cgcucuguac aaagguuccu gaacugaucc gcaccauuau gggcuggaca      420

cuugacuuuc ugagagagcg gcuccugggg uggauccagg aucagggagg cugggacggg      480

cuucugagcu auuucggaac ccccacaugg cagaccguga cgaucuuugu cgccggcgug      540

cucaccgcuu cccugacaau uuggaagaaa augggcuga                             579


<210>  6992
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bax__Homo_sapiens__AAA03619

<400>  6992
auggauggaa guggagaaca accaagagga ggaggaccaa caagcaguga acaaauaaug       60

aaaacaggag cauuauuauu acaaggauuu auacaagaua gagcaggaag aaugggagga      120

gaagcaccag aauuagcauu agauccagua ccacaagaug caagcacaaa aaaacuaagc      180

gaaugcuuaa aaagaauagg agaugaauua gauaguaaua uggaauuaca aagaaugaua      240

gcagcaguag auacagauag uccaagagaa guauuuuuca gaguagcagc agauauguuu      300

agugacggaa auuuuaauug gggaagagua guagcauuau uuuauuuugc aaguaaauua      360

guauuaaaag cauuauguac aaaaguacca gaauuaauaa gaacaauaau gggauggaca      420

uuagauuuuc uaagagaaag acuuuuagga uggauacaag aucaaggagg augggaugga      480

cuauuaaguu auuucggaac accaacaugg caaacaguaa caauauuugu agcaggagua      540

uuaacagcaa guuuaacaau auggaaaaaa auggguuga                             579


<210>  6993
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bcl-10__Homo_sapiens__O95999

<400>  6993

Met Glu Pro Thr Ala Pro Ser Leu Thr Glu Glu Asp Leu Thr Glu Val 
1               5                   10                  15      


Lys Lys Asp Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile 
            20                  25                  30          


Ile Ala Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser 
        35                  40                  45              


Arg Glu Asp Thr Glu Glu Ile Ser Cys Arg Thr Ser Ser Arg Lys Arg 
    50                  55                  60                  


Ala Gly Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp 
65                  70                  75                  80  


Thr Leu Val Glu Ser Ile Arg Arg Glu Lys Thr Gln Asn Phe Leu Ile 
                85                  90                  95      


Gln Lys Ile Thr Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu 
            100                 105                 110         


His Leu Lys Gly Leu Lys Cys Ser Ser Cys Glu Pro Phe Pro Asp Gly 
        115                 120                 125             


Ala Thr Asn Asn Leu Ser Arg Ser Asn Ser Asp Glu Ser Asn Phe Ser 
    130                 135                 140                 


Glu Lys Leu Arg Ala Ser Thr Val Met Tyr His Pro Glu Gly Glu Ser 
145                 150                 155                 160 


Ser Thr Thr Pro Phe Phe Ser Thr Asn Ser Ser Leu Asn Leu Pro Val 
                165                 170                 175     


Leu Glu Val Gly Arg Thr Glu Asn Thr Ile Phe Ser Ser Thr Thr Leu 
            180                 185                 190         


Pro Arg Pro Gly Asp Pro Gly Ala Pro Pro Leu Pro Pro Asp Leu Gln 
        195                 200                 205             


Leu Glu Glu Glu Gly Thr Cys Ala Asn Ser Ser Glu Met Phe Leu Pro 
    210                 215                 220                 


Leu Arg Ser Arg Thr Val Ser Arg Gln 
225                 230             


<210>  6994
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bcl-10__Homo_sapiens__AAC99767

<400>  6994
auggagccca ccgcaccguc ccucaccgag gaggaccuca cugaagugaa gaaggacgcc       60

uuagaaaauu uacguguaua ccugugugag aaaaucauag cugagagaca uuuugaucau      120

cuacgugcaa aaaaaauacu caguagagaa gacacugaag aaauuucuug ucgaacauca      180

aguagaaaaa gggcuggaaa auuguuagac uacuuacagg aaaacccaaa aggucuggac      240

acccuuguug aaucuauucg gcgagaaaaa acacagaacu uccugauaca gaagauuaca      300

gaugaagugc ugaaacuuag aaauauaaaa cuagaacauc ugaaaggacu aaaauguagc      360

aguugugaac cuuuuccaga uggagccacg aacaaccucu ccagaucaaa uucagaugag      420

aguaauuucu cugaaaaacu gagggcaucc acugucaugu accauccaga aggagaaucc      480

agcacgacgc ccuuuuuuuc uacuaauucu ucucugaauu ugccuguucu agaaguaggc      540

agaacugaaa auaccaucuu cucuucaacu acacuuccca gaccugggga cccaggggcu      600

ccuccuuugc caccagaucu acaguuagaa gaagaaggaa cuugugcaaa cucuagugag      660

auguuucuuc ccuuaagauc acguacuguu ucacgacaau ga                         702


<210>  6995
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  6995
auggagccca ccgcccccag ccugaccgag gaggaccuca cggaggugaa gaaggacgcc       60

cuggagaacc ugcgcgucua ccucugcgag aagaucaucg cggagcggca cuucgaccac      120

cuccgcgcca agaagauccu gucccgggag gacaccgagg agaucagcug ccgcaccucc      180

agccggaagc gcgccggcaa gcugcuggac uaccugcagg agaaccccaa ggggcucgac      240

acccuggugg aguccauccg gcgcgagaag acgcagaacu uccugaucca gaagaucacc      300

gacgaggugc ucaagcugcg gaacaucaag cuggagcacc ucaagggccu gaagugcagc      360

uccugcgagc ccuuccccga cggggccacc aacaaccuga gccgcuccaa cagcgacgag      420

uccaacuuca gcgagaagcu ccgggccucc accgucaugu accacccgga gggcgagagc      480

uccacgaccc ccuucuucag caccaacucc agccugaacc ugcccgugcu cgaggugggg      540

cgcaccgaga acacgaucuu cuccagcacc acccugcccc ggccgggcga ccccggcgcg      600

ccgccccugc cgcccgaccu ccagcuggag gaggagggga ccugcgccaa cagcuccgag      660

auguuccugc cccuccgcag ccggacgguc ucccgccagu ga                         702


<210>  6996
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  6996
auggagccca ccgcccccuc ccucaccgag gaggaccuca ccgaggucaa gaaggacgcc       60

cucgagaacc uccgcgucua ccucugcgag aagaucaucg ccgagcgcca cuucgaccac      120

cuccgcgcca agaagauccu cucccgcgag gacaccgagg agaucuccug ccgcaccucc      180

ucccgcaagc gcgccggcaa gcuccucgac uaccuccagg agaaccccaa gggccucgac      240

acccucgucg aguccauccg ccgcgagaag acccagaacu uccucaucca gaagaucacc      300

gacgaggucc ucaagcuccg caacaucaag cucgagcacc ucaagggccu caagugcucc      360

uccugcgagc ccuuccccga cggcgccacc aacaaccucu cccgcuccaa cuccgacgag      420

uccaacuucu ccgagaagcu ccgcgccucc accgucaugu accaccccga gggcgagucc      480

uccaccaccc ccuucuucuc caccaacucc ucccucaacc uccccguccu cgaggucggc      540

cgcaccgaga acaccaucuu cuccuccacc acccuccccc gccccggcga ccccggcgcc      600

cccccccucc cccccgaccu ccagcucgag gaggagggca ccugcgccaa cuccuccgag      660

auguuccucc cccuccgcuc ccgcaccguc ucccgccagu ga                         702


<210>  6997
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  6997
auggagccca ccgccccuag ccugacagaa gaggaccuca cugaagugaa gaaggaugcu       60

cuugagaacc ugagagucua cuugugcgaa aagaucauug cagagaggca cuucgaccau      120

uuacgggcca aaaagauacu gucccgcgag gauacggaag agaucucuug ucgaaccuca      180

agucguaaaa gagcgggcaa gcuacucgac uaucugcagg aaaauccaaa ggggcuugau      240

acacugguug agagcauuag gcgggagaaa acucaaaacu uuuugaucca gaagauuacc      300

gacgaagugc ucaaacugcg caauaucaag cuggagcacc ucaaaggauu aaagugcucc      360

ucuugugaac cguuccccga uggugcuaca aacaaucugu cgagaucaaa cagcgacgag      420

aguaauuuuu ccgaaaaacu uagggccucu accguaaugu accauccuga gggcgagagc      480

uccacuacac cauucuuuuc aaccaacagu agcuugaauc ugcccgugcu agaagucggg      540

cggacggaga acacuauauu cucuuccacc acacucccuc gcccaggaga ucccggcgca      600

ccuccacugc cgcccgaccu ucagcuggaa gaggaaggua cuugcgccaa uucaagcgag      660

auguuuuugc cucuccgaag uagaaccgug ucuaggcagu ga                         702


<210>  6998
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  6998
auggagccca ccgcccccag ccugaccgag gaggaccuga ccgaggugaa gaaggacgcc       60

cuggagaacc ugagagugua ccugugcgag aagaucaucg ccgagagaca cuucgaccac      120

cugagagcca agaagauccu gagcagagag gacaccgagg agaucagcug cagaaccagc      180

agcagaaaga gagccggcaa gcugcuggac uaccugcagg agaaccccaa gggccuggac      240

acccuggugg agagcaucag aagagagaag acccagaacu uccugaucca gaagaucacc      300

gacgaggugc ugaagcugag aaacaucaag cuggagcacc ugaagggccu gaagugcagc      360

agcugcgagc ccuuccccga cggcgccacc aacaaccuga gcagaagcaa cagcgacgag      420

agcaacuuca gcgagaagcu gagagccagc accgugaugu accaccccga gggcgagagc      480

agcaccaccc ccuucuucag caccaacagc agccugaacc ugcccgugcu ggaggugggc      540

agaaccgaga acaccaucuu cagcagcacc acccugccca gacccggcga ccccggcgcc      600

cccccccugc cccccgaccu gcagcuggag gaggagggca ccugcgccaa cagcagcgag      660

auguuccugc cccugagaag cagaaccgug agcagacagu ga                         702


<210>  6999
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  6999
auggagccca ccgccccuag ccugacagaa gaggaccuca cggaagugaa gaaagaugcu       60

cuggagaacc uuagagucua ccugugcgaa aagaucauug ccgagcggca cuucgaccau      120

cuccgcgcga aaaagauccu guccagagag gauaccgaag agauuucuug ucggacaagc      180

ucccgcaaaa gagcuggcaa acuucuggac uaucuccagg aaaauccgaa ggggcuggau      240

acccugguug agucuauccg gcgcgagaag acacaaaacu uucucauuca gaagaucacc      300

gacgaagugc ugaaacuuag aaauaucaag cuggagcacc ucaaaggacu gaagugcagc      360

uccugugaac ccuucccuga uggcgccaca aacaaucuuu cucggagcaa cuccgacgag      420

agcaauuuuu cugaaaagcu gcgcgccucc accgugaugu accaucccga gggggagagc      480

ucuacgaccc cuuucuuuuc cacaaacagc ucucucaauc ugcccguccu ggaaguggga      540

agaaccgaga acacaauuuu cuccagcacc acgcucccuc ggccgggcga ucccggggcu      600

ccuccccugc cucccgaccu ucagcuggaa gaggaaggaa caugcgccaa uuccucugag      660

auguuucucc cgcugcgcag cagaaccguu ucccggcagu ga                         702


<210>  7000
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bcl-10__Homo_sapiens__AAC99767

<400>  7000
auggaaccaa cagcaccauc acuaaccgaa gaagaccuaa cagaagucaa aaaagacgca       60

cuagaaaacc uaagaguaua ccuaugcgaa aaaauaauag cagaaagaca cuucgaccac      120

cuaagagcaa aaaaaauccu auccagagaa gacacagaag aaauaucaug cagaacauca      180

agcagaaaaa gagcaggaaa acuauuagac uaccuucaag aaaacccaaa aggcuuagac      240

acucuaguag aauccauaag aagagaaaaa acacaaaacu ucuuaauaca aaaaauaaca      300

gacgaaguac uaaaauuaag aaacauaaaa cuugaacacc uaaaaggacu aaaaugcuca      360

ucaugcgaac cauucccaga uggagcaaca aacaaccuau caagaucaaa cuccgacgaa      420

ucaaacuucu ccgaaaaacu acgagcauca acaguaaugu accacccaga aggagaaagc      480

uccacaacac cauuuuucag uacaaacuca ucacuaaacc uaccaguauu agaaguagga      540

agaacagaaa acacaauauu cucaucaaca acacuaccaa gaccaggaga cccaggagca      600

ccaccacucc caccagaccu acaacuagaa gaagaaggaa caugcgccaa cucaagcgaa      660

auguuccuac cacuaagauc aagaacagua ucaagacaau aa                         702


<210>  7001
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__A8ASI8

<400>  7001

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210>  7002
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__ACD47108

<400>  7002
auggacugug aggucaacaa cgguuccagc cucagggaug agugcaucac aaaccuacug       60

guguuuggcu uccuccaaag cuguucugac aacagcuucc gcagagagcu ggacgcacug      120

ggccacgagc ugccagugcu ggcuccccag ugggagggcu acgaugagcu gcagacugau      180

ggcaaccgca gcagccacuc ccgcuuggga agaauagagg cagauucuga aagucaagaa      240

gacaucaucc ggaauauugc caggcaccuc gcccaggucg gggacagcau ggaccguagc      300

aucccuccgg gccuggugaa cggccuggcc cugcagcuca ggaacaccag ccggucggag      360

gaggaccgga acagggaccu ggccacugcc cuggagcagc ugcugcaggc cuacccuaga      420

gacauggaga aggagaagac caugcuggug cuggcccugc ugcuggccaa gaagguggcc      480

agucacacgc cguccuugcu ccgugauguc uuucacacaa cagugaauuu uauuaaccag      540

aaccuacgca ccuacgugag gagcuuagcc agaaauggga uggacuga                   588


<210>  7003
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bid__Homo_sapiens__ACD47108

<400>  7003
auggacugcg aggugaacaa cggcagcucc cugcgcgacg agugcaucac caaccuccug       60

gucuucgggu uccugcagag cugcuccgac aacagcuucc ggcgcgagcu cgacgcccug      120

ggccacgagc ugcccgugcu cgccccgcag ugggaggggu acgacgagcu gcagaccgac      180

ggcaaccggu ccagccacuc ccgccugggg cggaucgagg cggacagcga gucccaggag      240

gacaucaucc gcaacaucgc ccggcaccuc gcccaggugg gcgacagcau ggaccgcucc      300

aucccgcccg gccuggucaa cgggcuggcc cuccagcugc ggaacacgag ccgcuccgag      360

gaggaccgga accgcgaccu ggccaccgcg cucgagcagc ugcugcaggc cuacccccgg      420

gacauggaga aggagaagac caugcucgug cuggcccugc uccuggccaa gaagguggcg      480

agccacaccc ccucccugcu ccgcgacguc uuccacacga ccgugaacuu caucaaccag      540

aaccugcgga ccuacgugcg cagccuggcc cggaacggca uggacuga                   588


<210>  7004
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bid__Homo_sapiens__ACD47108

<400>  7004
auggacugcg aggucaacaa cggcuccucc cuccgcgacg agugcaucac caaccuccuc       60

gucuucggcu uccuccaguc cugcuccgac aacuccuucc gccgcgagcu cgacgcccuc      120

ggccacgagc uccccguccu cgccccccag ugggagggcu acgacgagcu ccagaccgac      180

ggcaaccgcu ccucccacuc ccgccucggc cgcaucgagg ccgacuccga gucccaggag      240

gacaucaucc gcaacaucgc ccgccaccuc gcccaggucg gcgacuccau ggaccgcucc      300

aucccccccg gccucgucaa cggccucgcc cuccagcucc gcaacaccuc ccgcuccgag      360

gaggaccgca accgcgaccu cgccaccgcc cucgagcagc uccuccaggc cuacccccgc      420

gacauggaga aggagaagac caugcucguc cucgcccucc uccucgccaa gaaggucgcc      480

ucccacaccc ccucccuccu ccgcgacguc uuccacacca ccgucaacuu caucaaccag      540

aaccuccgca ccuacguccg cucccucgcc cgcaacggca uggacuga                   588


<210>  7005
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bid__Homo_sapiens__ACD47108

<400>  7005
auggacugcg aagugaacaa uggcagcucc cugagagaug aauguaucac caaccuccuu       60

gucuucgggu uucugcaguc uugcucagac aauaguuuca ggcgggaguu ggaugccuua      120

ggacacgaac ugcccguucu agcuccucaa ugggaggguu acgacgaacu ccagacagau      180

ggcaaccgca gcucccauuc ucgacugggg cguauugagg cagacucgga gucacaggaa      240

gauauaauca gaaauauugc caggcaccuu gcucaggugg gagacagcau ggaucggagu      300

aucccaccgg gccugguaaa cgguuuggcg cuccaacugc gcaauacuuc cagaucugag      360

gaagacagga accgggaucu ggccacggca cucgagcagu uacugcaggc cuauccccgc      420

gacauggaga aggagaaaac caugcuugug uuggcucugc uacucgcaaa gaaagucgcc      480

agccauacac cuucccugcu ucgagaugug uuucacacua ccguuaauuu cauuaaccag      540

aaucugagaa cauacgugag gucauuggcu cggaacggga uggacuga                   588


<210>  7006
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bid__Homo_sapiens__ACD47108

<400>  7006
auggacugcg aggugaacaa cggcagcagc cugagagacg agugcaucac caaccugcug       60

guguucggcu uccugcagag cugcagcgac aacagcuuca gaagagagcu ggacgcccug      120

ggccacgagc ugcccgugcu ggccccccag ugggagggcu acgacgagcu gcagaccgac      180

ggcaacagaa gcagccacag cagacugggc agaaucgagg ccgacagcga gagccaggag      240

gacaucauca gaaacaucgc cagacaccug gcccaggugg gcgacagcau ggacagaagc      300

aucccccccg gccuggugaa cggccuggcc cugcagcuga gaaacaccag cagaagcgag      360

gaggacagaa acagagaccu ggccaccgcc cuggagcagc ugcugcaggc cuaccccaga      420

gacauggaga aggagaagac caugcuggug cuggcccugc ugcuggccaa gaagguggcc      480

agccacaccc ccagccugcu gagagacgug uuccacacca ccgugaacuu caucaaccag      540

aaccugagaa ccuacgugag aagccuggcc agaaacggca uggacuga                   588


<210>  7007
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bid__Homo_sapiens__ACD47108

<400>  7007
auggacugcg aagugaacaa uggcagcucc cugagagaug aauguaucac caaccuccug       60

gucuucgggu uucuucaguc uugcagcgac aauuccuucc ggcgcgagcu ggaugcccuc      120

ggacacgaac ugcccguucu ugcuccucaa ugggagggcu acgacgaacu gcagacagau      180

gggaacagau cuagccauuc ccggcucgga cgcauugagg ccgacucuga gagccaggaa      240

gauaucauua gaaauaucgc gcggcaccug gcucaggugg gcgacuccau ggaucgcagc      300

auuccgcccg ggcuggugaa cggacucgcc cugcaacuua gaaauacguc ucgguccgag      360

gaagaccgca acagagaucu ggccaccgcu cucgagcagc ugcuucaggc cuauccucgg      420

gacauggaga aggagaaaac aaugcugguc cucgcucugc ugcucgccaa gaaaguggcg      480

agccauaccc ccucucugcu ucgcgauguu uuucacacaa ccgugaauuu caucaaccag      540

aaucugagaa cauacguccg gucccucgcc cgcaacggca uggacuga                   588


<210>  7008
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bid__Homo_sapiens__ACD47108

<400>  7008
auggauugcg aaguaaauaa cggaucauca cuaagagacg aaugcauaac aaaucuauua       60

guauuuggau uucuacaaag uuguagcgau aacucauuca gaagagaacu agaugcauua      120

ggacaugaau uaccaguacu agcaccacaa ugggaaggau augacgaauu acaaacagau      180

ggaaauagau caagccauag uagacuagga agaauagaag cagacucaga aucacaagaa      240

gacauaauac gaaacauagc aagacacuua gcacaaguag gagacucaau ggauagaucg      300

auaccaccag gacuaguaaa cggacuagca cuacaacuaa gaaacacaag uagaagcgaa      360

gaagauagaa auagagaucu agcaacagca cuagaacaac uacuacaagc uuauccaaga      420

gacauggaaa aagaaaaaac aaugcuagua cuagcacuau uacucgcaaa aaaaguagca      480

agucacacac caagcuuauu aagagacgua uuccauacaa caguaaauuu cauaaaccaa      540

aacuuaagaa cauacguaag aucauuagca agaaauggaa uggacuaa                   588


<210>  7009
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__B2ZP78

<400>  7009

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Gly Ala Ser Asp Asn Asn 
65                  70                  75                  80  


Thr Ala Ser Ala Glu Glu Glu Thr Glu Ala Ala Gly Ser Val Ala Val 
                85                  90                  95      


Glu Arg Gly Leu His Gly Ala Ala Thr Val Val Leu Gly Gln Gly Gln 
            100                 105                 110         


His Gly Gly Cys Ala Pro Glu Glu Glu Asp 
        115                 120         


<210>  7010
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__ACD47106

<400>  7010
auggacugug aggucaacaa cgguuccagc cucagggaug agugcaucac aaaccuacug       60

guguuuggcu uccuccaaag cuguucugac aacagcuucc gcagagagcu ggacgcacug      120

ggccacgagc ugccagugcu ggcuccccag ugggagggcu acgaugagcu gcagacugau      180

ggcaaccgca gcagccacuc ccgcuuggga agaauagagg caggggcguc agacaauaac      240

acagcaagug cugaggaaga aacggaggcg gcagggagcg uggcaguuga gcguggccuu      300

cauggagcug cgacaguggu acucgggcag gggcagcacg gaggcugugc gccagaggag      360

gaggacuga                                                              369


<210>  7011
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bid__Homo_sapiens__ACD47106

<400>  7011
auggacugcg aggugaacaa cggcagcucc cugcgcgacg agugcaucac caaccuccug       60

gucuucgggu uccugcagag cugcuccgac aacagcuucc ggcgcgagcu cgacgcccug      120

ggccacgagc ugcccgugcu cgccccgcag ugggaggggu acgacgagcu gcagaccgac      180

ggcaaccggu ccagccacuc ccgccugggg cggaucgagg cgggcgccag cgacaacaac      240

acggccuccg ccgaggagga gaccgaggcc gcgggcagcg uggccgucga gcgcgggcuc      300

cacggcgccg ccaccguggu gcuggggcag ggccagcacg ggggcugcgc gcccgaggag      360

gaggacuga                                                              369


<210>  7012
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bid__Homo_sapiens__ACD47106

<400>  7012
auggacugcg aggucaacaa cggcuccucc cuccgcgacg agugcaucac caaccuccuc       60

gucuucggcu uccuccaguc cugcuccgac aacuccuucc gccgcgagcu cgacgcccuc      120

ggccacgagc uccccguccu cgccccccag ugggagggcu acgacgagcu ccagaccgac      180

ggcaaccgcu ccucccacuc ccgccucggc cgcaucgagg ccggcgccuc cgacaacaac      240

accgccuccg ccgaggagga gaccgaggcc gccggcuccg ucgccgucga gcgcggccuc      300

cacggcgccg ccaccgucgu ccucggccag ggccagcacg gcggcugcgc ccccgaggag      360

gaggacuga                                                              369


<210>  7013
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bid__Homo_sapiens__ACD47106

<400>  7013
auggacugcg aggugaacaa uggcagcucc cugagagaug aauguaucac caaccuccuu       60

gucuucgggu uucugcaguc uugcucagac aauaguuuca ggcgggaguu ggaugccuua      120

ggacacgaac ugcccguucu agcuccucaa ugggaggguu acgacgaacu ccagacagau      180

ggcaaccgca gcucccauuc ucgacugggg cguauugagg caggagccuc ggacaauaac      240

acugcgucag cugaggaaga gacggaagcc gcaggcagcg uggccguaga gagaggucuu      300

cacggggcug caaccguggu ccugggacag ggccagcaug gcgggugugc cccagaggaa      360

gaggauuga                                                              369


<210>  7014
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bid__Homo_sapiens__ACD47106

<400>  7014
auggacugcg aggugaacaa cggcagcagc cugagagacg agugcaucac caaccugcug       60

guguucggcu uccugcagag cugcagcgac aacagcuuca gaagagagcu ggacgcccug      120

ggccacgagc ugcccgugcu ggccccccag ugggagggcu acgacgagcu gcagaccgac      180

ggcaacagaa gcagccacag cagacugggc agaaucgagg ccggcgccag cgacaacaac      240

accgccagcg ccgaggagga gaccgaggcc gccggcagcg uggccgugga gagaggccug      300

cacggcgccg ccaccguggu gcugggccag ggccagcacg gcggcugcgc ccccgaggag      360

gaggacuga                                                              369


<210>  7015
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bid__Homo_sapiens__ACD47106

<400>  7015
auggacugcg aggugaacaa uggcagcucc cugagagaug aauguaucac caaccuccug       60

gucuucgggu uucuucaguc uugcagcgac aauuccuucc ggcgcgagcu ggaugcccuc      120

ggacacgaac ugcccguucu ugcuccucaa ugggagggcu acgacgaacu gcagacagau      180

gggaacagau cuagccauuc ccggcucgga cgcauugagg ccggcgcguc ugacaauaac      240

acggcuagcg ccgaggaaga gaccgaagcc gcuggguccg uggccgugga gagaggacug      300

cacggcgcug ccacagucgu gcugggccag gggcagcaug gaggcugugc gccggaggaa      360

gaggauuga                                                              369


<210>  7016
<211>  369
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bid__Homo_sapiens__ACD47106

<400>  7016
auggauugug aaguaaauaa uggaaguagu uuaagagaug aauguauaac aaauuuauua       60

guauuuggau uuuuacaaag uuguagugau aauaguuuua gaagagaauu agaugcauua      120

ggacaugaau uaccaguauu agcaccacaa ugggaaggau augaugaacu acaaacagau      180

ggaaauagaa guagucauag cagauuagga agaauagaag caggagcaag ugauaauaau      240

acagcaagug cagaagaaga aacagaagca gcaggaagcg uagcaguaga aagaggauua      300

cauggagcag caacaguagu acuaggacaa ggacaacaug gaggaugugc accagaagaa      360

gaagauuaa                                                              369


<210>  7017
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__B2ZP79

<400>  7017

Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
1               5                   10                  15      


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
            20                  25                  30          


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
        35                  40                  45              


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
    50                  55                  60                  


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
65                  70                  75                  80  


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
                85                  90                  95      


Gly Met Asp 
            


<210>  7018
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__ACD47107

<400>  7018
auggaccgua gcaucccucc gggccuggug aacggccugg cccugcagcu caggaacacc       60

agccggucgg aggaggaccg gaacagggac cuggccacug cccuggagca gcugcugcag      120

gccuacccua gagacaugga gaaggagaag accaugcugg ugcuggcccu gcugcuggcc      180

aagaaggugg ccagucacac gccguccuug cuccgugaug ucuuucacac aacagugaau      240

uuuauuaacc agaaccuacg caccuacgug aggagcuuag ccagaaaugg gauggacuga      300


<210>  7019
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bid__Homo_sapiens__ACD47107

<400>  7019
auggaccgca gcaucccgcc cggccuggug aacgggcucg cccugcagcu gcggaacacc       60

ucccgcagcg aggaggaccg gaaccgcgac cucgccaccg cgcuggagca gcugcuccag      120

gccuaccccc gggacaugga gaaggagaag acgaugcugg uccuggcccu ccugcuggcc      180

aagaaggugg ccucccacac ccccagccuc cugcgcgacg uguuccacac caccgucaac      240

uucaucaacc agaaccugcg gacguacgug cgcucccucg cgcggaacgg cauggacuga      300


<210>  7020
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bid__Homo_sapiens__ACD47107

<400>  7020
auggaccgcu ccaucccccc cggccucguc aacggccucg cccuccagcu ccgcaacacc       60

ucccgcuccg aggaggaccg caaccgcgac cucgccaccg cccucgagca gcuccuccag      120

gccuaccccc gcgacaugga gaaggagaag accaugcucg uccucgcccu ccuccucgcc      180

aagaaggucg ccucccacac ccccucccuc cuccgcgacg ucuuccacac caccgucaac      240

uucaucaacc agaaccuccg caccuacguc cgcucccucg cccgcaacgg cauggacuga      300


<210>  7021
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bid__Homo_sapiens__ACD47107

<400>  7021
auggacagaa gcauuccccc uggccuggug aacgggcucg cccuucagcu gaggaauacc       60

ucccggucug aggaagaucg caaccgagac uuggcuacag cauuagagca acugcuacag      120

gccuacccac gugauaugga aaaggagaaa acuaugcucg uccuggcgcu ucuguuggcu      180

aagaaaguug ccucacacac gccgagucuc cugagagacg uguuccauac cacaguaaau      240

uuuaucaacc agaaucugag gacuuaugug cggagccucg cacgcaacgg aauggauuga      300


<210>  7022
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bid__Homo_sapiens__ACD47107

<400>  7022
auggacagaa gcaucccccc cggccuggug aacggccugg cccugcagcu gagaaacacc       60

agcagaagcg aggaggacag aaacagagac cuggccaccg cccuggagca gcugcugcag      120

gccuacccca gagacaugga gaaggagaag accaugcugg ugcuggcccu gcugcuggcc      180

aagaaggugg ccagccacac ccccagccug cugagagacg uguuccacac caccgugaac      240

uucaucaacc agaaccugag aaccuacgug agaagccugg ccagaaacgg cauggacuga      300


<210>  7023
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bid__Homo_sapiens__ACD47107

<400>  7023
auggacagaa gcauuccccc uggccuggug aacgggcucg cccugcagcu ucggaauacc       60

ucccgcucug aggaagauag aaaccgggac cuggcuacag cccucgagca acugcuucag      120

gcguacccgc gcgauaugga aaaggagaaa acgaugcugg uccucgcucu gcugcucgcc      180

aagaaaguug ccagccacac ccccucccug cuuagagacg uguuccauac aaccgugaau      240

uuuaucaacc agaaucugcg gacauauguc cgcucucucg cuagaaacgg aauggauuga      300


<210>  7024
<211>  300
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bid__Homo_sapiens__ACD47107

<400>  7024
auggacagau caauaccacc aggacuagua aacggacucg cacuacaacu aagaaacaca       60

agcagaagcg aagaagacag aaacagagac cuagcaacag cacuagaaca acuacuacaa      120

gcauacccaa gagacaugga aaaagaaaaa acaaugcuag uauuagcacu acuacuagca      180

aaaaaaguag caagccacac accaagccua cuaagagacg uauuccauac aacaguaaac      240

uucauaaacc aaaaccuaag aacauacgua agaucacuag caagaaacgg aauggacuaa      300


<210>  7025
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__P55957

<400>  7025

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210>  7026
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bid__Homo_sapiens__AAC34365

<400>  7026
auggacugug aggucaacaa cgguuccagc cucagggaug agugcaucac aaaccuacug       60

guguuuggcu uccuccaaag cuguucugac aacagcuucc gcagagagcu ggacgcacug      120

ggccacgagc ugccagugcu ggcuccccag ugggagggcu acgaugagcu gcagacugau      180

ggcaaccgca gcagccacuc ccgcuuggga agaauagagg cagauucuga aagucaagaa      240

gacaucaucc ggaauauugc caggcaccuc gcccaggucg gggacagcau ggaccguagc      300

aucccuccgg gccuggugaa cggccuggcc cugcagcuca ggaacaccag ccggucggag      360

gaggaccgga acagggaccu ggccacugcc cuggagcagc ugcugcaggc cuacccuaga      420

gacauggaga aggagaagac caugcuggug cuggcccugc ugcuggccaa gaagguggcc      480

agucacacgc cguccuugcu ccgugauguc uuucacacaa cagugaauuu uauuaaccag      540

aaccuacgca ccuacgugag gagcuuagcc agaaauggga uggacuga                   588


<210>  7027
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bid__Homo_sapiens__AAC34365

<400>  7027
auggacugcg aggugaacaa cggcagcucc cugcgcgacg agugcaucac caaccuccug       60

gucuucgggu uccugcagag cugcuccgac aacagcuucc ggcgcgagcu cgacgcccug      120

ggccacgagc ugcccgugcu cgccccgcag ugggaggggu acgacgagcu gcagaccgac      180

ggcaaccggu ccagccacuc ccgccugggg cggaucgagg cggacagcga gucccaggag      240

gacaucaucc gcaacaucgc ccggcaccuc gcccaggugg gcgacagcau ggaccgcucc      300

aucccgcccg gccuggucaa cgggcuggcc cuccagcugc ggaacacgag ccgcuccgag      360

gaggaccgga accgcgaccu ggccaccgcg cucgagcagc ugcugcaggc cuacccccgg      420

gacauggaga aggagaagac caugcucgug cuggcccugc uccuggccaa gaagguggcg      480

agccacaccc ccucccugcu ccgcgacguc uuccacacga ccgugaacuu caucaaccag      540

aaccugcgga ccuacgugcg cagccuggcc cggaacggca uggacuga                   588


<210>  7028
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bid__Homo_sapiens__AAC34365

<400>  7028
auggacugcg aggucaacaa cggcuccucc cuccgcgacg agugcaucac caaccuccuc       60

gucuucggcu uccuccaguc cugcuccgac aacuccuucc gccgcgagcu cgacgcccuc      120

ggccacgagc uccccguccu cgccccccag ugggagggcu acgacgagcu ccagaccgac      180

ggcaaccgcu ccucccacuc ccgccucggc cgcaucgagg ccgacuccga gucccaggag      240

gacaucaucc gcaacaucgc ccgccaccuc gcccaggucg gcgacuccau ggaccgcucc      300

aucccccccg gccucgucaa cggccucgcc cuccagcucc gcaacaccuc ccgcuccgag      360

gaggaccgca accgcgaccu cgccaccgcc cucgagcagc uccuccaggc cuacccccgc      420

gacauggaga aggagaagac caugcucguc cucgcccucc uccucgccaa gaaggucgcc      480

ucccacaccc ccucccuccu ccgcgacguc uuccacacca ccgucaacuu caucaaccag      540

aaccuccgca ccuacguccg cucccucgcc cgcaacggca uggacuga                   588


<210>  7029
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bid__Homo_sapiens__AAC34365

<400>  7029
auggacugcg aagugaacaa uggcagcucc cugagagaug aauguaucac caaccuccuu       60

gucuucgggu uucugcaguc uugcucagac aauaguuuca ggcgggaguu ggaugccuua      120

ggacacgaac ugcccguucu agcuccucaa ugggaggguu acgacgaacu ccagacagau      180

ggcaaccgca gcucccauuc ucgacugggg cguauugagg cagacucgga gucacaggaa      240

gauauaauca gaaauauugc caggcaccuu gcucaggugg gagacagcau ggaucggagu      300

aucccaccgg gccugguaaa cgguuuggcg cuccaacugc gcaauacuuc cagaucugag      360

gaagacagga accgggaucu ggccacggca cucgagcagu uacugcaggc cuauccccgc      420

gacauggaga aggagaaaac caugcuugug uuggcucugc uacucgcaaa gaaagucgcc      480

agccauacac cuucccugcu ucgagaugug uuucacacua ccguuaauuu cauuaaccag      540

aaucugagaa cauacgugag gucauuggcu cggaacggga uggacuga                   588


<210>  7030
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bid__Homo_sapiens__AAC34365

<400>  7030
auggacugcg aggugaacaa cggcagcagc cugagagacg agugcaucac caaccugcug       60

guguucggcu uccugcagag cugcagcgac aacagcuuca gaagagagcu ggacgcccug      120

ggccacgagc ugcccgugcu ggccccccag ugggagggcu acgacgagcu gcagaccgac      180

ggcaacagaa gcagccacag cagacugggc agaaucgagg ccgacagcga gagccaggag      240

gacaucauca gaaacaucgc cagacaccug gcccaggugg gcgacagcau ggacagaagc      300

aucccccccg gccuggugaa cggccuggcc cugcagcuga gaaacaccag cagaagcgag      360

gaggacagaa acagagaccu ggccaccgcc cuggagcagc ugcugcaggc cuaccccaga      420

gacauggaga aggagaagac caugcuggug cuggcccugc ugcuggccaa gaagguggcc      480

agccacaccc ccagccugcu gagagacgug uuccacacca ccgugaacuu caucaaccag      540

aaccugagaa ccuacgugag aagccuggcc agaaacggca uggacuga                   588


<210>  7031
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bid__Homo_sapiens__AAC34365

<400>  7031
auggacugcg aagugaacaa uggcagcucc cugagagaug aauguaucac caaccuccug       60

gucuucgggu uucuucaguc uugcagcgac aauuccuucc ggcgcgagcu ggaugcccuc      120

ggacacgaac ugcccguucu ugcuccucaa ugggagggcu acgacgaacu gcagacagau      180

gggaacagau cuagccauuc ccggcucgga cgcauugagg ccgacucuga gagccaggaa      240

gauaucauua gaaauaucgc gcggcaccug gcucaggugg gcgacuccau ggaucgcagc      300

auuccgcccg ggcuggugaa cggacucgcc cugcaacuua gaaauacguc ucgguccgag      360

gaagaccgca acagagaucu ggccaccgcu cucgagcagc ugcuucaggc cuauccucgg      420

gacauggaga aggagaaaac aaugcugguc cucgcucugc ugcucgccaa gaaaguggcg      480

agccauaccc ccucucugcu ucgcgauguu uuucacacaa ccgugaauuu caucaaccag      540

aaucugagaa cauacguccg gucccucgcc cgcaacggca uggacuga                   588


<210>  7032
<211>  588
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bid__Homo_sapiens__AAC34365

<400>  7032
auggauugcg aaguaaauaa cggaagcuca cuaagagacg aaugcauaac aaaucuauua       60

guauuuggau uuuuacaaag cuguagcgau aacaguuuca gaagagaacu agacgcacuc      120

ggacaugaac uaccaguacu agcaccacaa ugggaaggau augacgaacu acaaacagau      180

ggaaauagau caagccauag cagacuagga agaauagaag cagacucaga aucacaagaa      240

gacauaauaa gaaacauagc aagacaccuu gcacaaguag gagacuccau ggauagauca      300

auaccaccag gacuaguaaa cggacuagca cuacaacuaa gaaacacaag cagaucagaa      360

gaagacagaa auagagaucu agcaacagcc cuagaacaau uacuacaagc auauccaaga      420

gacauggaaa aagaaaaaac aauguuagua cuagcacuau uauuagcaaa aaaaguagca      480

agccauacac caucauuacu aagagacgua uuccauacaa caguaaacuu cauaaaccaa      540

aaccuaagaa cauacguacg aucucuagca agaaauggaa uggacuaa                   588


<210>  7033
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bik__Homo_sapiens__A0A024R4X6

<400>  7033

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 






<210>  7034
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bik__Homo_sapiens__EAW73284

<400>  7034
augucugaag uaagaccccu cuccagagac aucuugaugg agacccuccu guaugagcag       60

cuccuggaac ccccgaccau ggagguucuu ggcaugacug acucugaaga ggaccuggac      120

ccuauggagg acuucgauuc uuuggaaugc auggagggca gugacgcauu ggcccugcgg      180

cuggccugca ucggggacga gauggacgug agccucaggg ccccgcgccu ggcccagcuc      240

uccgaggugg ccaugcacag ccugggucug gcuuucaucu acgaccagac ugaggacauc      300

agggauguuc uuagaaguuu cauggacggu uucaccacac uuaaggagaa cauaaugagg      360

uucuggagau ccccgaaccc cggguccugg guguccugcg aacaggugcu gcuggcgcug      420

cugcugcugc uggcgcugcu gcugccgcug cucagcgggg gccugcaccu gcugcucaag      480

uga                                                                    483


<210>  7035
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bik__Homo_sapiens__EAW73284

<400>  7035
augagcgagg ugcgcccccu gucccgggac auccucaugg agacccugcu guacgagcag       60

cuccuggagc cgcccaccau ggaggugcug ggcaugacgg acagcgagga ggaccucgac      120

cccauggagg acuucgacuc ccuggagugc auggagggga gcgacgcccu ggcccuccgc      180

cuggcgugca ucggcgacga gauggacgug ucccugcggg cgccccgccu cgcccagcug      240

agcgaggugg ccaugcacuc ccuggggcuc gccuucaucu acgaccagac cgaggacauc      300

cgggacgucc ugcgcagcuu cauggacggc uucaccaccc ugaaggagaa caucaugcgg      360

uucuggcgcu ccccgaaccc cgggagcugg guguccugcg agcagguccu ccuggcccug      420

cuccugcugc ucgcccugcu gcucccccug cugagcggcg gccuccaccu ccugcugaag      480

uga                                                                    483


<210>  7036
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bik__Homo_sapiens__EAW73284

<400>  7036
auguccgagg uccgcccccu cucccgcgac auccucaugg agacccuccu cuacgagcag       60

cuccucgagc cccccaccau ggagguccuc ggcaugaccg acuccgagga ggaccucgac      120

cccauggagg acuucgacuc ccucgagugc auggagggcu ccgacgcccu cgcccuccgc      180

cucgccugca ucggcgacga gauggacguc ucccuccgcg ccccccgccu cgcccagcuc      240

uccgaggucg ccaugcacuc ccucggccuc gccuucaucu acgaccagac cgaggacauc      300

cgcgacgucc uccgcuccuu cauggacggc uucaccaccc ucaaggagaa caucaugcgc      360

uucuggcgcu cccccaaccc cggcuccugg gucuccugcg agcagguccu ccucgcccuc      420

cuccuccucc ucgcccuccu ccucccccuc cucuccggcg gccuccaccu ccuccucaag      480

uga                                                                    483


<210>  7037
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bik__Homo_sapiens__EAW73284

<400>  7037
augagcgagg ugagaccccu guccagggac auccucaugg aaacccuucu guacgagcag       60

uuguuagaac cuccaacaau ggagguccug ggcaugacug auucugaaga ggaccuagau      120

ccgauggagg acuucgauuc acucgaaugc auggagggga gugacgcccu ggcccuucgg      180

cuggcaugua uuggagauga aauggacguu agcuugcgcg cuccccgacu cgcgcaacug      240

uccgaggugg cuaugcacuc ucugggucuc gccuuuauau augaucagac ggaggacauc      300

cgugauguau uaagaucguu cauggacggc uuuaccacac ugaaggaaaa cauuaugagg      360

uucuggcggu caccuaaucc agggagcugg gugaguugcg agcagguccu uuuggcacug      420

cuacuccugc uugcccuguu gcucccccug uuauccggag gccugcaucu ccuucugaaa      480

uga                                                                    483


<210>  7038
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bik__Homo_sapiens__EAW73284

<400>  7038
augagcgagg ugagaccccu gagcagagac auccugaugg agacccugcu guacgagcag       60

cugcuggagc cccccaccau ggaggugcug ggcaugaccg acagcgagga ggaccuggac      120

cccauggagg acuucgacag ccuggagugc auggagggca gcgacgcccu ggcccugaga      180

cuggccugca ucggcgacga gauggacgug agccugagag cccccagacu ggcccagcug      240

agcgaggugg ccaugcacag ccugggccug gccuucaucu acgaccagac cgaggacauc      300

agagacgugc ugagaagcuu cauggacggc uucaccaccc ugaaggagaa caucaugaga      360

uucuggagaa gccccaaccc cggcagcugg gugagcugcg agcaggugcu gcuggcccug      420

cugcugcugc uggcccugcu gcugccccug cugagcggcg gccugcaccu gcugcugaag      480

uga                                                                    483


<210>  7039
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bik__Homo_sapiens__EAW73284

<400>  7039
augagcgagg ugagaccccu gucccgggac auccucaugg agacccugcu uuacgagcag       60

cugcucgaac cuccgacaau ggagguccug ggcaugacgg auucugaaga ggaccuugau      120

cccauggagg acuucgauag ccuggaaugc auggaggggu ccgacgcccu cgcucugcgc      180

cuggccugua uuggagauga aauggacguu ucucucagag cgccucggcu ggcucaacuu      240

agcgaggugg ccaugcacuc ccugggccuc gccuuuaucu augaucagac cgaggacauu      300

cgcgaugugc ugagaucuuu cauggacggg uuuacaaccc uuaaggaaaa caucaugcgg      360

uucuggcgca gccccaaucc uggauccugg gucagcugcg aacaggugcu gcucgcucug      420

cugcuccugc uugcccugcu ccugccccuu cugucuggcg ggcuccaucu gcugcucaaa      480

uga                                                                    483


<210>  7040
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bik__Homo_sapiens__EAW73284

<400>  7040
augucugaag uaagaccacu aucaagagau auauuaaugg aaacauuauu auaugaacaa       60

cuauuagaac cucccacaau ggaaguauua ggaaugacag auagugaaga agaucuagau      120

ccaauggaag auuucgauag uuuagaaugu auggaaggau cagacgcauu agcacuaaga      180

cuagcaugca uaggagauga aauggacgua agcuuaagag caccaagauu agcacaacua      240

agugaaguag caaugcauag cuuaggauua gcauuuauau augaccaaac agaagacaua      300

agagauguau uaagaucauu cauggacgga uucacaacau uaaaagaaaa cauaaugaga      360

uucuggagau caccaaaucc aggaagcugg guaucaugcg aacaaguacu acuagcauua      420

uuauuacuau uagcauuauu auuaccauua uuaucaggcg gacuacaucu auuacuaaaa      480

uaa                                                                    483


<210>  7041
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bik__Homo_sapiens__Q13323

<400>  7041

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 






<210>  7042
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bik__Homo_sapiens__AAC50413

<400>  7042
augucugaag uaagaccccu cuccagagac aucuugaugg agacccuccu guaugagcag       60

cuccuggaac ccccgaccau ggagguucuu ggcaugacug acucugaaga ggaccuggac      120

ccuauggagg acuucgauuc uuuggaaugc auggagggca gugacgcauu ggcccugcgg      180

cuggccugca ucggggacga gauggacgug agccucaggg ccccgcgccu ggcccagcuc      240

uccgaggugg ccaugcacag ccugggucug gcuuucaucu acgaccagac ugaggacauc      300

agggauguuc uuagaaguuu cauggacggu uucaccacac uuaaggagaa cauaaugagg      360

uucuggagau ccccgaaccc cggguccugg guguccugcg aacaggugcu gcuggcgcug      420

cugcugcugc uggcgcugcu gcugccgcug cucagcgggg gccugcaccu gcugcucaag      480

uga                                                                    483


<210>  7043
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bik__Homo_sapiens__AAC50413

<400>  7043
augagcgagg ugcgcccccu gucccgggac auccucaugg agacccugcu guacgagcag       60

cuccuggagc cgcccaccau ggaggugcug ggcaugacgg acagcgagga ggaccucgac      120

cccauggagg acuucgacuc ccuggagugc auggagggga gcgacgcccu ggcccuccgc      180

cuggcgugca ucggcgacga gauggacgug ucccugcggg cgccccgccu cgcccagcug      240

agcgaggugg ccaugcacuc ccuggggcuc gccuucaucu acgaccagac cgaggacauc      300

cgggacgucc ugcgcagcuu cauggacggc uucaccaccc ugaaggagaa caucaugcgg      360

uucuggcgcu ccccgaaccc cgggagcugg guguccugcg agcagguccu ccuggcccug      420

cuccugcugc ucgcccugcu gcucccccug cugagcggcg gccuccaccu ccugcugaag      480

uga                                                                    483


<210>  7044
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bik__Homo_sapiens__AAC50413

<400>  7044
auguccgagg uccgcccccu cucccgcgac auccucaugg agacccuccu cuacgagcag       60

cuccucgagc cccccaccau ggagguccuc ggcaugaccg acuccgagga ggaccucgac      120

cccauggagg acuucgacuc ccucgagugc auggagggcu ccgacgcccu cgcccuccgc      180

cucgccugca ucggcgacga gauggacguc ucccuccgcg ccccccgccu cgcccagcuc      240

uccgaggucg ccaugcacuc ccucggccuc gccuucaucu acgaccagac cgaggacauc      300

cgcgacgucc uccgcuccuu cauggacggc uucaccaccc ucaaggagaa caucaugcgc      360

uucuggcgcu cccccaaccc cggcuccugg gucuccugcg agcagguccu ccucgcccuc      420

cuccuccucc ucgcccuccu ccucccccuc cucuccggcg gccuccaccu ccuccucaag      480

uga                                                                    483


<210>  7045
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bik__Homo_sapiens__AAC50413

<400>  7045
augagcgagg ugagaccccu guccagggac auccucaugg aaacccuucu guacgagcag       60

uuguuagaac cuccaacaau ggagguccug ggcaugacug auucugaaga ggaccuagau      120

ccgauggagg acuucgauuc acucgaaugc auggagggga gugacgcccu ggcccuucgg      180

cuggcaugua uuggagauga aauggacguu agcuugcgcg cuccccgacu cgcgcaacug      240

uccgaggugg cuaugcacuc ucugggucuc gccuuuauau augaucagac ggaggacauc      300

cgugauguau uaagaucguu cauggacggc uuuaccacac ugaaggaaaa cauuaugagg      360

uucuggcggu caccuaaucc agggagcugg gugaguugcg agcagguccu uuuggcacug      420

cuacuccugc uugcccuguu gcucccccug uuauccggag gccugcaucu ccuucugaaa      480

uga                                                                    483


<210>  7046
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bik__Homo_sapiens__AAC50413

<400>  7046
augagcgagg ugagaccccu gagcagagac auccugaugg agacccugcu guacgagcag       60

cugcuggagc cccccaccau ggaggugcug ggcaugaccg acagcgagga ggaccuggac      120

cccauggagg acuucgacag ccuggagugc auggagggca gcgacgcccu ggcccugaga      180

cuggccugca ucggcgacga gauggacgug agccugagag cccccagacu ggcccagcug      240

agcgaggugg ccaugcacag ccugggccug gccuucaucu acgaccagac cgaggacauc      300

agagacgugc ugagaagcuu cauggacggc uucaccaccc ugaaggagaa caucaugaga      360

uucuggagaa gccccaaccc cggcagcugg gugagcugcg agcaggugcu gcuggcccug      420

cugcugcugc uggcccugcu gcugccccug cugagcggcg gccugcaccu gcugcugaag      480

uga                                                                    483


<210>  7047
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bik__Homo_sapiens__AAC50413

<400>  7047
augagcgagg ugagaccccu gucccgggac auccucaugg agacccugcu uuacgagcag       60

cugcucgaac cuccgacaau ggagguccug ggcaugacgg auucugaaga ggaccuugau      120

cccauggagg acuucgauag ccuggaaugc auggaggggu ccgacgcccu cgcucugcgc      180

cuggccugua uuggagauga aauggacguu ucucucagag cgccucggcu ggcucaacuu      240

agcgaggugg ccaugcacuc ccugggccuc gccuuuaucu augaucagac cgaggacauu      300

cgcgaugugc ugagaucuuu cauggacggg uuuacaaccc uuaaggaaaa caucaugcgg      360

uucuggcgca gccccaaucc uggauccugg gucagcugcg aacaggugcu gcucgcucug      420

cugcuccugc uugcccugcu ccugccccuu cugucuggcg ggcuccaucu gcugcucaaa      480

uga                                                                    483


<210>  7048
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bik__Homo_sapiens__AAC50413

<400>  7048
augucagaag uaagaccacu aucaagagau auauuaaugg aaacauuauu auaugaacaa       60

cuauuagaac caccaacaau ggaaguauua ggaaugacag auagugaaga agaucuagau      120

ccaauggaag auuucgauag cuuagaaugu auggaaggau cagacgcauu agcacuaaga      180

cuagcaugca uaggagauga aauggacgua aguuuaagag caccaagacu agcacaauua      240

agugaaguag caaugcauag cuuaggauua gcauuuauau augaccaaac cgaagacaua      300

agagauguau uaagaucauu cauggacgga uucacaacau uaaaagaaaa cauaaugaga      360

uucuggagau caccaaaucc aggaagcugg guaucaugcg aacaaguacu acuagcauua      420

cuauuacuau uagcauuacu auuaccacua cuaucuggag gacuacaucu auuacuaaaa      480

uaa                                                                    483


<210>  7049
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bim__Homo_sapiens__O43521

<400>  7049

Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Thr Ser Leu Gln Thr Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Thr Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Thr Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Thr Gln Thr Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro 
    130                 135                 140                 


Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn 
145                 150                 155                 160 


Ala Tyr Tyr Ala Arg Arg Val Phe Leu Asn Asn Tyr Gln Ala Ala Glu 
                165                 170                 175     


Asp His Pro Arg Met Val Ile Leu Arg Leu Leu Arg Tyr Ile Val Arg 
            180                 185                 190         


Leu Val Trp Arg Met His 
        195             


<210>  7050
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Bim__Homo_sapiens__AAC39593

<400>  7050
auggcaaagc aaccuucuga uguaaguucu gagugugacc gagaagguag acaauugcag       60

ccugcggaga ggccucccca gcucagaccu ggggccccua ccucccuaca gacagagcca      120

caagguaauc cugaaggcaa ucacggaggu gaaggggaca gcugccccca cggcagcccu      180

cagggcccgc uggccccacc ugccagcccu ggcccuuuug cuaccagauc cccgcuuuuc      240

aucuuuauga gaagauccuc ccugcugucu cgauccucca guggguauuu cucuuuugac      300

acagacagga gcccagcacc caugaguugu gacaaaucaa cacaaacccc aaguccuccu      360

ugccaggccu ucaaccacua ucucagugca auggcuucca ugaggcaggc ugaaccugca      420

gauaugcgcc cagagauaug gaucgcccaa gaguugcggc guaucggaga cgaguuuaac      480

gcuuacuaug caaggagggu auuuuugaau aauuaccaag cagccgaaga ccacccacga      540

augguuaucu uacgacuguu acguuacauu guccgccugg uguggagaau gcauuga         597


<210>  7051
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Bim__Homo_sapiens__AAC39593

<400>  7051
auggccaagc agcccagcga cguguccagc gagugcgacc gcgagggccg gcagcugcag       60

ccggccgagc gcccgcccca gcuccggccc ggggcgccca ccucccugca gaccgagccc      120

cagggcaacc ccgaggggaa ccacggcggg gagggcgaca gcugccccca cggcuccccg      180

caggggcccc uggccccgcc cgccagcccc ggccccuucg ccacgcgcag cccccucuuc      240

aucuucaugc ggcgcuccuc ccugcugagc cgguccagcu ccggguacuu cagcuucgac      300

accgaccgcu cccccgcccc gaugagcugc gacaagucca cccagacccc cagcccgccc      360

ugccaggcgu ucaaccacua ccucuccgcc auggccagca ugcggcaggc cgagcccgcg      420

gacaugcgcc ccgagaucug gaucgcccag gagcugcggc gcaucggcga cgaguucaac      480

gccuacuacg cccggcgcgu cuuccugaac aacuaccagg ccgcggagga ccacccccgg      540

auggugaucc uccgccugcu gcgguacauc gugcgccucg ucuggcggau gcacuga         597


<210>  7052
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Bim__Homo_sapiens__AAC39593

<400>  7052
auggccaagc agcccuccga cgucuccucc gagugcgacc gcgagggccg ccagcuccag       60

cccgccgagc gcccccccca gcuccgcccc ggcgccccca ccucccucca gaccgagccc      120

cagggcaacc ccgagggcaa ccacggcggc gagggcgacu ccugccccca cggcuccccc      180

cagggccccc ucgccccccc cgccuccccc ggccccuucg ccacccgcuc cccccucuuc      240

aucuucaugc gccgcuccuc ccuccucucc cgcuccuccu ccggcuacuu cuccuucgac      300

accgaccgcu cccccgcccc cauguccugc gacaagucca cccagacccc cucccccccc      360

ugccaggccu ucaaccacua ccucuccgcc auggccucca ugcgccaggc cgagcccgcc      420

gacaugcgcc ccgagaucug gaucgcccag gagcuccgcc gcaucggcga cgaguucaac      480

gccuacuacg cccgccgcgu cuuccucaac aacuaccagg ccgccgagga ccacccccgc      540

auggucaucc uccgccuccu ccgcuacauc guccgccucg ucuggcgcau gcacuga         597


<210>  7053
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Bim__Homo_sapiens__AAC39593

<400>  7053
auggccaagc agcccagcga cguguccucu gagugcgaua gagaaggcag gcaacugcag       60

ccugcugagc ggccaccgca gcuccgcccc ggggcaccua ccucacuuca gacagaacca      120

caaggaaacc ccgaggguaa ucacggcggg gaaggagaca guuguccuca uggcagccca      180

cagggucccc uggccccucc agcguccccg gggcccuucg cuacucgauc uccuuuguuu      240

aucuucaugc guagaucguc auuacugagc aggaguuccu cuggauacuu uagcuucgau      300

acggaccggu ccccagcccc caugucaugc gauaaaagua cccagacacc uagcccaccc      360

ugucaggcau uuaaccacua ucuaucugcc auggcuucca ugcgccaagc agagccggcc      420

gacaugagac cugagauuug gauagcucag gaacucaggc ggaucggcga ugaguucaau      480

gccuacuaug cgcgccgagu cuuucugaac aauuaccagg cagccgaaga ccaucccaga      540

augguuauuc uuaggcuguu gcgguauauc gugcgucucg uauggcgcau gcacuga         597


<210>  7054
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Bim__Homo_sapiens__AAC39593

<400>  7054
auggccaagc agcccagcga cgugagcagc gagugcgaca gagagggcag acagcugcag       60

cccgccgaga gaccccccca gcugagaccc ggcgccccca ccagccugca gaccgagccc      120

cagggcaacc ccgagggcaa ccacggcggc gagggcgaca gcugccccca cggcagcccc      180

cagggccccc uggccccccc cgccagcccc ggccccuucg ccaccagaag cccccuguuc      240

aucuucauga gaagaagcag ccugcugagc agaagcagca gcggcuacuu cagcuucgac      300

accgacagaa gccccgcccc caugagcugc gacaagagca cccagacccc cagccccccc      360

ugccaggccu ucaaccacua ccugagcgcc auggccagca ugagacaggc cgagcccgcc      420

gacaugagac ccgagaucug gaucgcccag gagcugagaa gaaucggcga cgaguucaac      480

gccuacuacg ccagaagagu guuccugaac aacuaccagg ccgccgagga ccaccccaga      540

auggugaucc ugagacugcu gagauacauc gugagacugg uguggagaau gcacuga         597


<210>  7055
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Bim__Homo_sapiens__AAC39593

<400>  7055
auggccaagc agcccagcga cguguccucu gagugcgaua gagaaggccg gcaacugcag       60

ccugcugagc gcccgcccca gcucagaccu ggggccccca ccagccugca gacagaaccu      120

caaggaaacc ccgagggcaa ucacggggga gaaggcgacu ccuguccuca ugggucuccg      180

cagggacccc uugcgccucc cgcuagcccu ggccccuucg ccacgcgguc cccgcuguuu      240

aucuucaugc gcagaucuag ccuccugucc cggucuagcu ccggcuacuu uagcuucgau      300

accgaccgcu cuccugcccc cauguccugc gauaaaagca cacagacccc uucuccuccc      360

ugucaggcuu uuaaccacua ucuuuccgcc auggcuagca ugagacaagc cgagcccgcg      420

gacaugcggc cggagauuug gaucgcccag gaacugcgca gaauugggga ugaguucaau      480

gcuuacuaug cccggcgcgu cuuucucaac aauuaccagg cugccgaaga ccaucccaga      540

augguuaucc ugcggcugcu ccgcuauauu gugagacugg uguggcggau gcacuga         597


<210>  7056
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Bim__Homo_sapiens__AAC39593

<400>  7056
auggcaaaac aaccaagcga cguaucauca gaaugugaca gagaaggaag acaauuacaa       60

ccagcagaaa gaccuccaca auuaagacca ggagcaccaa caucacuaca aacagaacca      120

caaggcaauc cagaaggaaa ucacggagga gaaggagacu cauguccaca cggaucacca      180

caaggaccau uagcaccacc agcaucacca ggaccauuug caacaagauc accacuauuc      240

auauucaugc gaagaucauc acuauuauca agaucaucau caggauacuu uucauuugac      300

acagacagaa guccagcacc aaugucaugc gauaaaucaa cacaaacacc aucaccacca      360

ugucaagcau ucaaucacua ucuaucagca auggcaucaa ugagacaagc agaaccagcc      420

gacaugagac cagaaauaug gauagcacaa gaacuaagac gaauaggaga ugaauucaac      480

gcauacuaug caagaagagu auucuuaaac aauuaccaag cagcagaaga ucacccaaga      540

augguaauau uacgacuauu aagauauaua guaagauuag uauggagaau gcacuaa         597


<210>  7057
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Blk__Homo_sapiens__P51451

<400>  7057

Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210>  7058
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Blk__Homo_sapiens__AAH07371

<400>  7058
auggggcugg uaaguagcaa aaagccggac aaggaaaagc cgaucaaaga gaaggacaag       60

ggccaaugga gcccccugaa ggucagcgcc caagacaagg acgccccgcc acugccgccc      120

cugguugucu ucaaccaccu uacuccucca ccgcccgaug aacaccugga ugaagacaag      180

cauuucgugg uggcucugua ugacuacacc gcuaugaaug aucgggaccu gcagaugcug      240

aagggggaga agcuacaggu ccugaaggga acuggagacu gguggcuggc caggucacuc      300

gucacaggaa gagaaggcua ugugcccagc aacuuugugg cccgagugga gagccuggaa      360

auggaaaggu gguucuuuag aucacagggu cggaaggagg cugagaggca gcuucuugcu      420

ccaaucaaca aggccggcuc cuuucuuauc agagagagug aaaccaacaa aggugccuuc      480

ucccugucug ugaaggaugu caccacccag ggggagcuga ucaagcacua uaagauccgc      540

ugccuggaug aagggggcua cuacaucucc ccccggauca ccuuccccuc gcuccaggcc      600

cuggugcagc acuauucuaa gaagggggau ggucuaugcc agaggcugac ccugcccugu      660

gugcgcccgg ccccgcagaa ucccugggcc caggaugaau gggagauccc ccggcagucu      720

cucaggcugg ucaggaaacu cgggucugga caauucggcg aagucuggau ggguuacuac      780

aaaaacaaca ugaagguggc cauuaagacg cugaaggagg gaaccauguc uccagaagcc      840

uuucugggug aggccaacgu gaugaaggcu cugcagcacg agcggcuggu ccgacucuac      900

gcagugguca ccaaggagcc caucuacauu gucaccgagu acauggccag aggaugccug      960

cuggauuucc ugaagacaga ugaagggagc agauugucac ucccaaggcu gauugacaug     1020

ucggcgcaga uugcugaagg gauggcauac auugagcgca ugaauuccau ccaccgcgac     1080

cugcgggcgg ccaacauccu ggugucugag gccuugugcu gcaaaauugc ugauuuuggc     1140

uuggcucgaa ucaucgacag ugaauacacg gcccaagagg gggccaaguu ccccaucaag     1200

uggacagccc cggaagccau ccacuucggg gucuucacca ucaaagcaga cguguggucg     1260

uuuggagucc uccugaugga aguugucacu uaugggcggg ugccauaccc agggaugagc     1320

aaccccgagg ucauccgcaa ccuggagcgc ggcuaccgca ugccgcgccc cgacaccugc     1380

ccgcccgagc uguaccgcgg cgucaucgcc gagugcuggc gcagccggcc cgaggagcgg     1440

cccaccuucg aguuccugca gucggugcug gaggacuucu acacggccac cgagcggcag     1500

uacgagcugc agcccuag                                                   1518


<210>  7059
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Blk__Homo_sapiens__AAH07371

<400>  7059
augggccugg ugagcuccaa gaagcccgac aaggagaagc cgaucaagga gaaggacaag       60

gggcagugga gcccccucaa ggucuccgcc caggacaagg acgccccgcc ccugccgccc      120

cugguggugu ucaaccaccu caccccgccg ccgcccgacg agcaccugga cgaggacaag      180

cacuucgucg uggcgcugua cgacuacacc gccaugaacg accgcgaccu ccagaugcug      240

aagggcgaga agcuccaggu gcugaagggg acgggcgacu gguggcuggc ccggagccug      300

gucaccgggc gcgagggcua cgugcccucc aacuucgugg cccgggucga gagccucgag      360

auggagcgcu gguucuuccg gucccagggc cgcaaggagg ccgagcggca gcugcuggcg      420

cccaucaaca aggccgggag cuuccucauc cgcgaguccg agaccaacaa gggcgccuuc      480

agccuguccg ugaaggacgu gaccacgcag ggggagcuga ucaagcacua caagauccgg      540

ugccucgacg agggcgggua cuacaucagc ccccgcauca ccuuccccuc ccugcaggcc      600

cugguccagc acuacagcaa gaagggcgac ggccucugcc agcggcugac ccugcccugc      660

gugcgccccg cgccccagaa ccccugggcc caggacgagu gggagauccc ccggcagucc      720

cuccgccugg ugcggaagcu ggggagcggc caguucgggg aggucuggau gggcuacuac      780

aagaacaaca ugaagguggc caucaagacc cucaaggagg gcacgauguc ccccgaggcc      840

uuccuggggg aggccaacgu gaugaaggcg cugcagcacg agcgccucgu ccggcuguac      900

gccgugguga ccaaggagcc caucuacauc gucaccgagu acauggcccg cggcugccug      960

cucgacuucc ugaagaccga cgaggggagc cggcuguccc ucccccgccu gaucgacaug     1020

agcgcccaga ucgccgaggg cauggcguac aucgagcgga ugaacagcau ccaccgcgac     1080

cugcgcgccg ccaacauccu cguguccgag gcccugugcu gcaagaucgc cgacuucggg     1140

cuggcgcgga ucaucgacag cgaguacacg gcccaggagg gcgccaaguu ccccaucaag     1200

uggaccgccc ccgaggccau ccacuucggc guguucacca ucaaggcgga cgucuggucc     1260

uucggggugc uccugaugga ggucgugacc uacggccgcg ugccguaccc cgggaugagc     1320

aaccccgagg ucauccggaa ccuggagcgc ggcuaccgga ugccccgccc ggacacgugc     1380

ccgcccgagc ucuaccgcgg ggugaucgcc gagugcuggc ggucccggcc cgaggagcgc     1440

cccaccuucg aguuccugca gagcgugcug gaggacuucu acaccgccac cgagcggcag     1500

uacgagcucc agcccuga                                                   1518


<210>  7060
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Blk__Homo_sapiens__AAH07371

<400>  7060
augggccucg ucuccuccaa gaagcccgac aaggagaagc ccaucaagga gaaggacaag       60

ggccaguggu ccccccucaa ggucuccgcc caggacaagg acgccccccc ccuccccccc      120

cucgucgucu ucaaccaccu cacccccccc ccccccgacg agcaccucga cgaggacaag      180

cacuucgucg ucgcccucua cgacuacacc gccaugaacg accgcgaccu ccagaugcuc      240

aagggcgaga agcuccaggu ccucaagggc accggcgacu gguggcucgc ccgcucccuc      300

gucaccggcc gcgagggcua cguccccucc aacuucgucg cccgcgucga gucccucgag      360

auggagcgcu gguucuuccg cucccagggc cgcaaggagg ccgagcgcca gcuccucgcc      420

cccaucaaca aggccggcuc cuuccucauc cgcgaguccg agaccaacaa gggcgccuuc      480

ucccucuccg ucaaggacgu caccacccag ggcgagcuca ucaagcacua caagauccgc      540

ugccucgacg agggcggcua cuacaucucc ccccgcauca ccuuccccuc ccuccaggcc      600

cucguccagc acuacuccaa gaagggcgac ggccucugcc agcgccucac ccuccccugc      660

guccgccccg ccccccagaa ccccugggcc caggacgagu gggagauccc ccgccagucc      720

cuccgccucg uccgcaagcu cggcuccggc caguucggcg aggucuggau gggcuacuac      780

aagaacaaca ugaaggucgc caucaagacc cucaaggagg gcaccauguc ccccgaggcc      840

uuccucggcg aggccaacgu caugaaggcc cuccagcacg agcgccucgu ccgccucuac      900

gccgucguca ccaaggagcc caucuacauc gucaccgagu acauggcccg cggcugccuc      960

cucgacuucc ucaagaccga cgagggcucc cgccucuccc ucccccgccu caucgacaug     1020

uccgcccaga ucgccgaggg cauggccuac aucgagcgca ugaacuccau ccaccgcgac     1080

cuccgcgccg ccaacauccu cgucuccgag gcccucugcu gcaagaucgc cgacuucggc     1140

cucgcccgca ucaucgacuc cgaguacacc gcccaggagg gcgccaaguu ccccaucaag     1200

uggaccgccc ccgaggccau ccacuucggc gucuucacca ucaaggccga cgucuggucc     1260

uucggcgucc uccucaugga ggucgucacc uacggccgcg uccccuaccc cggcaugucc     1320

aaccccgagg ucauccgcaa ccucgagcgc ggcuaccgca ugccccgccc cgacaccugc     1380

ccccccgagc ucuaccgcgg cgucaucgcc gagugcuggc gcucccgccc cgaggagcgc     1440

cccaccuucg aguuccucca guccguccuc gaggacuucu acaccgccac cgagcgccag     1500

uacgagcucc agcccuga                                                   1518


<210>  7061
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Blk__Homo_sapiens__AAH07371

<400>  7061
augggccugg ugagcuccaa gaaacccgac aaggagaaac cuaucaagga aaaagauaag       60

gggcaguggu cuccacucaa ggucucagcc caagacaaag augcuccgcc ccuuccucca      120

cugguugugu ucaaccacuu gacacccccu ccacccgacg agcauuuaga ugaagacaag      180

cacuuuguag uggcacugua cgauuauacc gccaugaaug acagagaucu acagaugcuc      240

aaaggagaga agcugcaggu ccuuaaaggu acuggcgacu gguggcuggc gaggaguuug      300

gugacggggc gggaaggaua cguuccuagc aacuucgugg cucgcgucga gucccucgag      360

auggaacgau gguuuuuccg uucucagggc agaaaggagg ccgaaaggca acugcuggca      420

ccaauuaaua aggccgguuc guuucucaua cgggagucag agaccaacaa aggggcuuuc      480

agcuuaagug ugaaggaugu aacaacucag ggagaacuga ucaaacauua uaagauucgc      540

ugccuugacg agggcggcua cuauaucucc ccgagaauua ccuuucccuc uuugcaggca      600

cugguucagc acuacagcaa aaagggggau ggacuauguc aaaggcucac acugccuugc      660

gugcggccag cuccccagaa uccuugggcc caggacgaau gggagauccc acgccagucc      720

cuucgacugg ucagaaaauu ggguucaggc caauucgggg aaguguggau gggauauuac      780

aagaacaaua ugaagguggc cauaaaaacc cucaaggagg gcacuaugag ucccgaggcg      840

uuucugggug aagcaaacgu caugaaagcc uuacagcaug agaggcuggu ucggcucuac      900

gcugugguaa caaaggaacc gaucuauauu gugaccgagu acauggcccg ugggugucuu      960

cuggacuucu ugaaaacgga ugaaggaagc cgccuaucuc ugccuagacu caucgacaug     1020

uccgcacaga uugcugaggg cauggccuau aucgagagga ugaacucaau acaccgggau     1080

cugcgagcgg ccaauauucu ugucagcgaa gcacugugcu guaagaucgc ugacuuuggc     1140

uuggcccgca uuaucgauag ugaguacacu gcucaagaag gggccaaguu ccccaucaaa     1200

uggaccgcac cagaggccau ucacuuugga guguucacaa uaaaggcuga cguuuggucu     1260

uucggugugc uccugaugga agucgugacu uauggcagag uaccuuaccc cgggaugucc     1320

aauccagagg uuaucaggaa cuuagagcgg ggauaucgca ugcccagacc ugauaccugc     1380

ccaccggaac uguacagggg cgugauugcg gaguguuggc guagccggcc cgaggaacga     1440

ccuacauuug aguuccuaca gucgguccuc gaagacuuuu acaccgcaac ggagagacag     1500

uaugaacugc agccauga                                                   1518


<210>  7062
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Blk__Homo_sapiens__AAH07371

<400>  7062
augggccugg ugagcagcaa gaagcccgac aaggagaagc ccaucaagga gaaggacaag       60

ggccagugga gcccccugaa ggugagcgcc caggacaagg acgccccccc ccugcccccc      120

cugguggugu ucaaccaccu gacccccccc ccccccgacg agcaccugga cgaggacaag      180

cacuucgugg uggcccugua cgacuacacc gccaugaacg acagagaccu gcagaugcug      240

aagggcgaga agcugcaggu gcugaagggc accggcgacu gguggcuggc cagaagccug      300

gugaccggca gagagggcua cgugcccagc aacuucgugg ccagagugga gagccuggag      360

auggagagau gguucuucag aagccagggc agaaaggagg ccgagagaca gcugcuggcc      420

cccaucaaca aggccggcag cuuccugauc agagagagcg agaccaacaa gggcgccuuc      480

agccugagcg ugaaggacgu gaccacccag ggcgagcuga ucaagcacua caagaucaga      540

ugccuggacg agggcggcua cuacaucagc cccagaauca ccuuccccag ccugcaggcc      600

cuggugcagc acuacagcaa gaagggcgac ggccugugcc agagacugac ccugcccugc      660

gugagacccg ccccccagaa ccccugggcc caggacgagu gggagauccc cagacagagc      720

cugagacugg ugagaaagcu gggcagcggc caguucggcg agguguggau gggcuacuac      780

aagaacaaca ugaagguggc caucaagacc cugaaggagg gcaccaugag ccccgaggcc      840

uuccugggcg aggccaacgu gaugaaggcc cugcagcacg agagacuggu gagacuguac      900

gccgugguga ccaaggagcc caucuacauc gugaccgagu acauggccag aggcugccug      960

cuggacuucc ugaagaccga cgagggcagc agacugagcc ugcccagacu gaucgacaug     1020

agcgcccaga ucgccgaggg cauggccuac aucgagagaa ugaacagcau ccacagagac     1080

cugagagccg ccaacauccu ggugagcgag gcccugugcu gcaagaucgc cgacuucggc     1140

cuggccagaa ucaucgacag cgaguacacc gcccaggagg gcgccaaguu ccccaucaag     1200

uggaccgccc ccgaggccau ccacuucggc guguucacca ucaaggccga cguguggagc     1260

uucggcgugc ugcugaugga gguggugacc uacggcagag ugcccuaccc cggcaugagc     1320

aaccccgagg ugaucagaaa ccuggagaga ggcuacagaa ugcccagacc cgacaccugc     1380

ccccccgagc uguacagagg cgugaucgcc gagugcugga gaagcagacc cgaggagaga     1440

cccaccuucg aguuccugca gagcgugcug gaggacuucu acaccgccac cgagagacag     1500

uacgagcugc agcccuga                                                   1518


<210>  7063
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Blk__Homo_sapiens__AAH07371

<400>  7063
augggccugg ugagcuccaa gaaacccgac aaggagaaac cuaucaagga aaaagauaag       60

gggcaguggu cuccgcucaa ggucagcgcc caagacaaag augcuccccc ucugcccccu      120

cuuguugugu ucaaccaccu gacacccccu ccgcccgacg agcaucucga ugaagacaag      180

cacuuugugg ucgcccugua cgauuauacc gcgaugaaug acagagaucu ucagaugcug      240

aaaggagaga agcuccaggu gcugaaaggc acgggggacu gguggcuggc ucggucccuc      300

guuaccggac gcgaaggcua cgugccuucu aacuucgucg ccagagugga gagccuggag      360

auggaacggu gguuuuuccg cucccagggg agaaaggagg ccgaacggca acuucuggcu      420

cccauuaaua aggccggauc uuuucucauc cgcgagagcg agacaaacaa aggcgcuuuc      480

ucccugagcg uuaaggaugu gaccacacag ggcgaacuua uuaaacauua uaagaucaga      540

ugccuggacg aagggggaua cuauauuucu ccucggauca ccuuucccuc ccuccaggcc      600

cugguccagc acuacagcaa aaagggcgau gggcuguguc aacgccucac acugccgugc      660

gugagaccug cgccccagaa uccuugggcc caggacgaau gggagauccc ccggcagucu      720

cuucgccugg ugagaaaacu cggauccggc caauucgggg aagucuggau gggauauuac      780

aagaacaaua ugaagguugc uauuaaaacc cugaaggagg gcacgaugag ccccgaggcc      840

uuucuuggcg aagcuaacgu gaugaaagcc cugcagcaug agcggcucgu gcgccuguac      900

gcggucguga ccaaggaacc uaucuauauu guuacagagu acauggccag agggugucug      960

cucgacuucc ugaaaaccga ugaaggaucu cggcuuuccc ugccgagacu caucgacaug     1020

agcgcucaga uugccgaggg cauggcuuau aucgagcgca ugaacuccau ucaccgggau     1080

cugagagccg ccaauauccu ugugucugaa gcucugugcu guaagaucgc ggacuuuggg     1140

cucgcccgca uuaucgauag cgaguacaca gcucaagaag gagccaaguu ccccauuaaa     1200

uggaccgccc cugaggcuau ccacuuuggc gucuucacga uuaaggccga cguguggucc     1260

uucgggguuc ugcugaugga aguggucaca uauggacggg ugcccuaccc uggcaugagc     1320

aaucccgagg ucaucagaaa ccucgagcgc ggcuaucgga ugccgagacc ugauaccugu     1380

cccccugaac uguaccgcgg ggugaucgcg gagugcuggc ggucuagacc cgaggagcgc     1440

ccuacauuug aguuccuuca guccguucug gaagacuuuu acaccgcuac cgagcggcag     1500

uaugaacucc agcccuga                                                   1518


<210>  7064
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Blk__Homo_sapiens__AAH07371

<400>  7064
augggauuag uaucaucaaa aaaaccagau aaagaaaaac caauaaaaga aaaagauaaa       60

ggacaaugga gcccauuaaa aguaucagca caagacaaag acgcaccacc auuaccaccc      120

cucguggugu uuaaucaccu uacacccccu ccaccagaug aacacuuaga cgaagauaaa      180

cauuuugucg uagcauuaua cgauuauaca gcaaugaacg acagagaucu acaaaugcug      240

aaaggagaaa aacuacaagu acucaaggga acaggugauu ggugguuagc gagaucauua      300

guaacaggaa gagaaggaua uguaccaagu aacuuuguag caagagucga aagucuagaa      360

auggaacgau gguucuuuag aucacaagga agaaaagaag cagagcgaca auuauuagca      420

ccaauaaaua aagcaggaag cuuccucaua agagaaagcg aaacuaauaa aggagcauuu      480

ucauuaucag uaaaagaugu aaccacacaa ggagaacuaa uaaaacauua uaaaauaaga      540

ugccuagaug aaggcggaua uuacauauca ccacgcauaa cauuucccag uuuacaagca      600

cuaguacagc auuauucaaa aaaaggcgau ggauuaugcc aaagacuaac auuaccaugu      660

guaagaccag caccacagaa cccaugggca caagaugaau gggaaauacc aagacaauca      720

cuuagauuag uaagaaaauu aggcuccgga caauuuggug aaguauggau ggguuacuac      780

aaaaauaaca ugaaaguagc uaucaaaaca uuaaaagaag guacaauguc accagaagcc      840

uucuuaggag aagcaaaugu aaugaaagcu cuccaacacg aacgauuagu gagacuuuac      900

gcaguaguaa caaaagaacc aauauacaua gucacagaau auauggcaag gggaugucuc      960

cuagacuuuc uaaaaacaga ugaaggauca agacuaucac uaccaagacu aauagauaug     1020

agcgcacaaa uagcugaagg cauggccuau auugaaagaa ugaauaguau ccauagagac     1080

uuacgagcag caaacauauu aguuagugaa gccuuaugcu guaaaauagc agauuuugga     1140

cuagcacgaa uaauagacuc agaauacacu gcacaggaag gugcuaaauu cccaauaaaa     1200

uggacagcuc cggaagcaau acacuuugga guauuuacaa uaaaagcgga cguuugguca     1260

uuuggagucu uacuaaugga aguaguaaca uauggaagag uuccauaucc aggaauguca     1320

aacccagaag uaauaagaaa ccuagaaaga ggauauagaa ugccaagacc agauacaugu     1380

ccaccagaau uauacagagg cguuauagcg gaaugcugga gaaguaggcc ugaagaaaga     1440

ccaacauuug aauuuuuaca aucaguacua gaagauuuuu acacugcaac agaaagacag     1500

uacgaauuac aaccauaa                                                   1518


<210>  7065
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_3__Homo_sapiens__P42574

<400>  7065

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  7066
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_3__Homo_sapiens__AAA74929

<400>  7066
auggagaaca cugaaaacuc aguggauuca aaauccauua aaaauuugga accaaagauc       60

auacauggaa gcgaaucaau ggacucugga auaucccugg acaacaguua uaaaauggau      120

uauccugaga uggguuuaug uauaauaauu aauaauaaga auuuucauaa aagcacugga      180

augacaucuc ggucugguac agaugucgau gcagcaaacc ucagggaaac auucagaaac      240

uugaaauaug aagucaggaa uaaaaaugau cuuacacgug aagaaauugu ggaauugaug      300

cgugauguuu cuaaagaaga ucacagcaaa aggagcaguu uuguuugugu gcuucugagc      360

cauggugaag aaggaauaau uuuuggaaca aauggaccug uugaccugaa aaaaauaaca      420

aacuuuuuca gaggggaucg uuguagaagu cuaacuggaa aacccaaacu uuucauuauu      480

caggccugcc gugguacaga acuggacugu ggcauugaga cagacagugg uguugaugau      540

gacauggcgu gucauaaaau accaguggag gccgacuucu uguaugcaua cuccacagca      600

ccugguuauu auucuuggcg aaauucaaag gauggcuccu gguucaucca gucgcuuugu      660

gccaugcuga aacaguaugc cgacaagcuu gaauuuaugc acauucuuac ccggguuaac      720

cgaaaggugg caacagaauu ugaguccuuu uccuuugacg cuacuuuuca ugcaaagaaa      780

cagauuccau guauuguuuc caugcucaca aaagaacucu auuuuuauca cuaa            834


<210>  7067
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7067
auggagaaca ccgagaacag cguggacucc aagagcauca agaaccugga gcccaagauc       60

auccacggcu ccgagagcau ggacuccggg aucagccucg acaacuccua caagauggac      120

uacccggaga ugggccugug caucaucauc aacaacaaga acuuccacaa gagcaccggg      180

augacguccc gcagcggcac cgacgucgac gccgccaacc ugcgggagac cuuccgcaac      240

cucaaguacg aggugcggaa caagaacgac cugacccgcg aggagaucgu ggagcugaug      300

cgggacgucu ccaaggagga ccacagcaag cgcuccagcu ucgugugcgu gcuccugucc      360

cacggggagg agggcaucau cuucggcacg aacgggcccg ucgaccugaa gaagaucacc      420

aacuucuucc ggggcgaccg cugccggagc cucaccggga agcccaagcu guucaucauc      480

caggcgugcc gcggcaccga gcuggacugc gggaucgaga cggacuccgg cguggacgac      540

gacauggccu gccacaagau ccccguggag gccgacuucc ucuacgccua cagcaccgcc      600

ccgggcuacu acuccuggcg gaacagcaag gacgggagcu gguucaucca gucccugugc      660

gcgaugcuga agcaguacgc cgacaagcuc gaguucaugc acauccugac ccgcgucaac      720

cggaaggugg ccaccgaguu cgagagcuuc uccuucgacg ccacguucca cgcgaagaag      780

cagauccccu gcaucgugag caugcugacc aaggagcucu acuucuacca cuga            834


<210>  7068
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7068
auggagaaca ccgagaacuc cgucgacucc aaguccauca agaaccucga gcccaagauc       60

auccacggcu ccgaguccau ggacuccggc aucucccucg acaacuccua caagauggac      120

uaccccgaga ugggccucug caucaucauc aacaacaaga acuuccacaa guccaccggc      180

augaccuccc gcuccggcac cgacgucgac gccgccaacc uccgcgagac cuuccgcaac      240

cucaaguacg agguccgcaa caagaacgac cucacccgcg aggagaucgu cgagcucaug      300

cgcgacgucu ccaaggagga ccacuccaag cgcuccuccu ucgucugcgu ccuccucucc      360

cacggcgagg agggcaucau cuucggcacc aacggccccg ucgaccucaa gaagaucacc      420

aacuucuucc gcggcgaccg cugccgcucc cucaccggca agcccaagcu cuucaucauc      480

caggccugcc gcggcaccga gcucgacugc ggcaucgaga ccgacuccgg cgucgacgac      540

gacauggccu gccacaagau ccccgucgag gccgacuucc ucuacgccua cuccaccgcc      600

cccggcuacu acuccuggcg caacuccaag gacggcuccu gguucaucca gucccucugc      660

gccaugcuca agcaguacgc cgacaagcuc gaguucaugc acauccucac ccgcgucaac      720

cgcaaggucg ccaccgaguu cgaguccuuc uccuucgacg ccaccuucca cgccaagaag      780

cagauccccu gcaucgucuc caugcucacc aaggagcucu acuucuacca cuga            834


<210>  7069
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7069
auggagaaca ccgaaaauag cguggacucc aagucuauca aaaaccugga gcccaagauu       60

auacacggcu cagaaaguau ggauagcggg aucucccucg acaauucuua caaaauggau      120

uauccugaga ugggacuuug cauuaucauu aacaauaaga acuuccauaa aucgacaggu      180

augacuucaa gaagcggcac ggacgucgau gccgcuaauc ugagggaaac cuuucggaac      240

uugaaguacg agguucgcaa uaagaacgac uuaacacgag aggaaaucgu ggagcugaug      300

cgugauguaa guaaagaaga ccacuccaag agaucuagcu ucgugugugu ccuacucucc      360

cauggggagg agggaauaau cuuuggcacu aaugguccag uggaucugaa aaagauuacc      420

aacuucuuua ggggagaccg gugccgcuca cuuacaggga aaccgaagcu guucaucauu      480

caggcaugua gaggcaccga auuggauugc ggcaucgaga cugacagugg gguugaugac      540

gacauggccu gucacaagau acccguggaa gcggauuuuc ucuaugcuua cagcacagcc      600

ccuggauauu acucuuggag gaacuccaaa gacgguucau gguucauuca aagccugugc      660

gcaaugcuga agcaguaugc cgauaaacuc gaguuuaugc auaucuuaac ccgggucaau      720

cgcaaggugg cuacggaguu cgaaaguuuu ucuuucgacg caacuuuuca cgccaaaaag      780

cagauuccau guaucguauc caugcugacc aaagagcuuu acuucuacca cuga            834


<210>  7070
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7070
auggagaaca ccgagaacag cguggacagc aagagcauca agaaccugga gcccaagauc       60

auccacggca gcgagagcau ggacagcggc aucagccugg acaacagcua caagauggac      120

uaccccgaga ugggccugug caucaucauc aacaacaaga acuuccacaa gagcaccggc      180

augaccagca gaagcggcac cgacguggac gccgccaacc ugagagagac cuucagaaac      240

cugaaguacg aggugagaaa caagaacgac cugaccagag aggagaucgu ggagcugaug      300

agagacguga gcaaggagga ccacagcaag agaagcagcu ucgugugcgu gcugcugagc      360

cacggcgagg agggcaucau cuucggcacc aacggccccg uggaccugaa gaagaucacc      420

aacuucuuca gaggcgacag augcagaagc cugaccggca agcccaagcu guucaucauc      480

caggccugca gaggcaccga gcuggacugc ggcaucgaga ccgacagcgg cguggacgac      540

gacauggccu gccacaagau ccccguggag gccgacuucc uguacgccua cagcaccgcc      600

cccggcuacu acagcuggag aaacagcaag gacggcagcu gguucaucca gagccugugc      660

gccaugcuga agcaguacgc cgacaagcug gaguucaugc acauccugac cagagugaac      720

agaaaggugg ccaccgaguu cgagagcuuc agcuucgacg ccaccuucca cgccaagaag      780

cagauccccu gcaucgugag caugcugacc aaggagcugu acuucuacca cuga            834


<210>  7071
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7071
auggagaaca ccgaaaauag cguggacucc aagucuauca aaaaccugga gcccaagauu       60

auccacggca gcgaauccau ggauucuggg auuagccucg acaauuccua caaaauggau      120

uauccugaga ugggacugug caucauuauc aacaauaaga acuuccauaa aucuacaggc      180

augacgagca gauccgggac cgacgucgau gccgcuaauc uucgggaaac auuucgcaac      240

cugaaguacg agguuagaaa uaagaacgac cucacccggg aggaaaucgu ggagcugaug      300

cgcgauguga gcaaagaaga ccacucuaag agauccagcu ucgucugugu gcuucugucu      360

cauggagagg agggcauuau cuuugggaca aauggaccgg uugaucucaa aaagauuacc      420

aacuucuuuc ggggcgaccg cugcagaucc cugacaggca aacccaagcu guucaucauu      480

caggccuguc gggggaccga acucgauugc ggaaucgaga cggacagcgg cguggaugac      540

gacauggcgu gucacaagau uccugucgaa gcugauuuuc uguaugccua cucuaccgcc      600

cccggguauu acuccuggcg caauagcaaa gacggauccu gguucaucca aucucuuugc      660

gcuaugcuga agcaguaugc cgauaaacuc gaguuuaugc auauccugac aagagugaac      720

cggaagguug cuaccgaauu ugagagcuuc uccuucgacg ccacauuuca cgcgaaaaag      780

cagauuccuu guaucgugag caugcuuacc aaagagcugu acuucuacca cuga            834


<210>  7072
<211>  834
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_3__Homo_sapiens__AAA74929

<400>  7072
auggaaaaca cagaaaauag cguagacuca aaaucaauaa aaaaccuaga accaaaaaua       60

auacacggau cagaaucaau ggacucagga auaagccuag acaacucaua caaaauggau      120

uacccagaaa ugggauuaug cauaauaaua aacaacaaaa acuuccauaa aucaacagga      180

augaccucaa gaagcggcac agacguagac gcagcaaacc uaagagaaac auucagaaac      240

cuaaaauacg aaguaagaaa caaaaacgac cuaacaagag aagaaauagu agaacuaaug      300

agagacguau caaaagaaga ccauuccaaa agaucaucau ucguaugcgu acuacuaagc      360

cacggagaag aaggaauaau auucggaacc aacggaccag uagaccuaaa aaaaauuacc      420

aacuuuuuuc gaggagacag augccgauca cuaaccggaa aaccaaaauu auucauaaua      480

caagcaugca gaggcacaga acuagacugc ggaauagaaa cagacucagg aguagacgac      540

gacauggcau gccacaaaau acccguagaa gcagauuucc uauaugcaua caguacagca      600

ccaggauacu auucauggag aaacucaaaa gacggcagcu gguucauaca aucacuaugc      660

gcaauguuaa aacaauacgc agacaaacua gaauucaugc acauauuaac aagaguaaac      720

agaaaaguag caacagaauu cgaaucauuc agcuucgacg caacauucca cgcaaaaaaa      780

caaauaccau gcauaguauc aaugcuaaca aaagaacuau acuucuacca cuaa            834


<210>  7073
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_6__Homo_sapiens__P55212

<400>  7073

Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala Gly Gly Glu 
1               5                   10                  15      


Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys Arg Glu Met Phe Asp 
            20                  25                  30          


Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly Ile Ala Leu 
        35                  40                  45              


Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu Pro Glu Arg 
    50                  55                  60                  


Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp 
65                  70                  75                  80  


Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu 
                85                  90                  95      


Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala Asp Ala Asp 
            100                 105                 110         


Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn His Ile Tyr 
        115                 120                 125             


Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys 
    130                 135                 140                 


Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val Ile Pro Leu Asp 
                165                 170                 175     


Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr Asn Ile Thr Glu Val 
            180                 185                 190         


Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met 
        195                 200                 205             


Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn 
    210                 215                 220                 


Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly 
225                 230                 235                 240 


Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val 
                245                 250                 255     


Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys 
            260                 265                 270         


Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe 
        275                 280                 285             


Phe Pro Lys Ser Asn 
    290             


<210>  7074
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_6__Homo_sapiens__AAH00305

<400>  7074
augagcucgg ccucggggcu ccgcaggggg cacccggcag guggggaaga aaacaugaca       60

gaaacagaug ccuucuauaa aagagaaaug uuugauccgg cagaaaagua caaaauggac      120

cacaggagga gaggaauugc uuuaaucuuc aaucaugaga gguucuuuug gcacuuaaca      180

cugccagaaa ggcggggcac cugcgcagau agagacaauc uuacccgcag guuuucagau      240

cuaggauuug aagugaaaug cuuuaaugau cuuaaagcag aagaacuacu gcucaaaauu      300

caugaggugu caacuguuag ccacgcagau gccgauugcu uugugugugu cuuccugagc      360

cauggcgaag gcaaucacau uuaugcauau gaugcuaaaa ucgaaauuca gacauuaacu      420

ggcuuguuca aaggagacaa gugucacagc cugguuggaa aacccaagau auuuaucauu      480

caggcauguc ggggaaacca gcacgaugug ccagucauuc cuuuggaugu aguagauaau      540

cagacagaga aguuggacac caacauaacu gagguggaug cagccuccgu uuacacgcug      600

ccugcuggag cugacuuccu cauguguuac ucuguugcag aaggauauua uucucaccgg      660

gaaacuguga acggcucaug guacauucaa gauuugugug agauguuggg aaaauauggc      720

uccuccuuag aguucacaga acuccucaca cuggugaaca ggaaaguuuc ucagcgccga      780

guggacuuuu gcaaagaccc aagugcaauu ggaaagaagc agguucccug uuuugccuca      840

augcuaacua aaaagcugca uuucuuucca aaaucuaauu aa                         882


<210>  7075
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7075
augagcuccg ccagcggccu gcgccggggg caccccgccg gcggggagga gaacaugacc       60

gagaccgacg cguucuacaa gcgcgagaug uucgacccgg ccgagaagua caagauggac      120

caccggcgcc ggggcaucgc ccucaucuuc aaccacgagc gcuucuucug gcaccugacg      180

cugcccgagc ggcgcgggac cugcgccgac cgggacaacc ucacccgccg guucuccgac      240

cugggcuucg aggugaagug cuucaacgac cugaaggccg aggagcuccu gcugaagauc      300

cacgagguga gcaccguguc ccacgcggac gccgacugcu ucgugugcgu cuuccucagc      360

cacggcgagg ggaaccacau cuacgccuac gacgccaaga ucgagaucca gacgcugacc      420

ggccuguuca agggggacaa gugccacucc cucgugggca agcccaagau cuucaucauc      480

caggcgugcc gcgggaacca gcacgacgug cccgucaucc cgcuggacgu gguggacaac      540

cagaccgaga agcuggacac caacaucacg gaggucgacg ccgccagcgu guacacccuc      600

cccgccggcg ccgacuuccu gaugugcuac uccguggcgg agggcuacua cagccaccgg      660

gagaccguca acggguccug guacauccag gaccugugcg agaugcucgg caaguacggg      720

agcucccugg aguucaccga gcugcucacg cuggugaacc gcaaggugag ccagcggcgc      780

gucgacuucu gcaaggaccc cuccgccauc ggcaagaagc agguccccug cuucgccagc      840

augcugacca agaagcucca cuucuucccg aaguccaacu ga                         882


<210>  7076
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7076
auguccuccg ccuccggccu ccgccgcggc caccccgccg gcggcgagga gaacaugacc       60

gagaccgacg ccuucuacaa gcgcgagaug uucgaccccg ccgagaagua caagauggac      120

caccgccgcc gcggcaucgc ccucaucuuc aaccacgagc gcuucuucug gcaccucacc      180

cuccccgagc gccgcggcac cugcgccgac cgcgacaacc ucacccgccg cuucuccgac      240

cucggcuucg aggucaagug cuucaacgac cucaaggccg aggagcuccu ccucaagauc      300

cacgaggucu ccaccgucuc ccacgccgac gccgacugcu ucgucugcgu cuuccucucc      360

cacggcgagg gcaaccacau cuacgccuac gacgccaaga ucgagaucca gacccucacc      420

ggccucuuca agggcgacaa gugccacucc cucgucggca agcccaagau cuucaucauc      480

caggccugcc gcggcaacca gcacgacguc cccgucaucc cccucgacgu cgucgacaac      540

cagaccgaga agcucgacac caacaucacc gaggucgacg ccgccuccgu cuacacccuc      600

cccgccggcg ccgacuuccu caugugcuac uccgucgccg agggcuacua cucccaccgc      660

gagaccguca acggcuccug guacauccag gaccucugcg agaugcucgg caaguacggc      720

uccucccucg aguucaccga gcuccucacc cucgucaacc gcaaggucuc ccagcgccgc      780

gucgacuucu gcaaggaccc cuccgccauc ggcaagaagc agguccccug cuucgccucc      840

augcucacca agaagcucca cuucuucccc aaguccaacu ga                         882


<210>  7077
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7077
augagcuccg ccucuggccu uagaaggggg caccccgcug gaggugagga aaacaugacc       60

gagacagacg cauucuacaa gcgggaaaug uuugauccug ccgagaaaua uaagauggac      120

caucgccgac guggcaucgc gcucauuuuc aaucacgaaa gauuuuucug gcaucuuacu      180

cugccagaga ggcgggggac gugcgcugau cgcgacaacu ugaccagaag guuuucagau      240

uuaggauucg aggugaaaug uuuuaaugac cugaaggccg aggaacuacu ccugaaaaua      300

cacgaaguca guacaguuag ccaugcagau gccgacugcu ucgugugugu auuucuuucc      360

cacggcgagg guaaccacau cuacgcuuau gaugcaaaga uugagaucca gacucugacc      420

ggguuguuca agggagacaa augccauucu cucgugggca agccgaaaau uuuuaucaua      480

caagccuguc ggggcaauca gcacgauguc cccgugaucc cucuggacgu uguggauaac      540

cagacagaaa agcuggacac caauauuacu gaggucgacg cugccucggu guacacacuc      600

ccagcggggg cagauuucuu aaugugcuau ucaguagccg aaggauacua uagccaucgc      660

gagaccguua acgguaguug guacauccag gaccugugug aaaugcuugg caaauacggg      720

uccucuuugg aguuuacgga gcugcuaacu cucgugaauc gaaaggucag ccaaagaagg      780

guggauuucu gcaaggaccc cuccgcuauu ggaaagaaac aggugccuug uuucgccuca      840

augcugacca aaaagcugca cuuuuuccca aaaaguaacu ga                         882


<210>  7078
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7078
augagcagcg ccagcggccu gagaagaggc caccccgccg gcggcgagga gaacaugacc       60

gagaccgacg ccuucuacaa gagagagaug uucgaccccg ccgagaagua caagauggac      120

cacagaagaa gaggcaucgc ccugaucuuc aaccacgaga gauucuucug gcaccugacc      180

cugcccgaga gaagaggcac cugcgccgac agagacaacc ugaccagaag auucagcgac      240

cugggcuucg aggugaagug cuucaacgac cugaaggccg aggagcugcu gcugaagauc      300

cacgagguga gcaccgugag ccacgccgac gccgacugcu ucgugugcgu guuccugagc      360

cacggcgagg gcaaccacau cuacgccuac gacgccaaga ucgagaucca gacccugacc      420

ggccuguuca agggcgacaa gugccacagc cuggugggca agcccaagau cuucaucauc      480

caggccugca gaggcaacca gcacgacgug cccgugaucc cccuggacgu gguggacaac      540

cagaccgaga agcuggacac caacaucacc gagguggacg ccgccagcgu guacacccug      600

cccgccggcg ccgacuuccu gaugugcuac agcguggccg agggcuacua cagccacaga      660

gagaccguga acggcagcug guacauccag gaccugugcg agaugcuggg caaguacggc      720

agcagccugg aguucaccga gcugcugacc cuggugaaca gaaaggugag ccagagaaga      780

guggacuucu gcaaggaccc cagcgccauc ggcaagaagc aggugcccug cuucgccagc      840

augcugacca agaagcugca cuucuucccc aagagcaacu ga                         882


<210>  7079
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7079
augagcuccg ccucuggacu uagacggggg caccccgcug gaggcgagga aaacaugacc       60

gagacagacg ccuucuacaa gcgcgaaaug uuugauccug cggagaaaua uaagauggac      120

cauagacggc gcgggaucgc ucucauuuuc aaucacgaaa gauuuuucug gcaucugacg      180

cuuccggagc ggcgcggaac cugcgccgau agagacaacc ugacacggcg cuuuagcgau      240

cucggcuucg aggugaaaug uuuuaaugac cugaaggccg aggaacuucu gcucaaaauc      300

cacgaagucu ccaccguuuc ucaugcugau gccgacugcu ucgugugugu guuucugagc      360

cacggggagg gaaaccacau uuacgcuuau gaugccaaga ucgagauuca gacacugacc      420

ggccucuuca agggcgacaa augccauucc cuggucggga agcccaaaau cuuuaucauu      480

caagcgugua gaggaaauca gcacgaugug ccuguuaucc cccuugacgu ggucgauaac      540

cagacagaaa agcuggacac caauauuacg gagguggacg ccgcuucugu uuacacccuc      600

ccugccggcg cugauuuccu gaugugcuau agcguggccg aaggguacua uucccaucgg      660

gagacaguca acggaagcug guacauccag gaccuuugug aaaugcuggg caaauacggg      720

ucuucccucg aguuuaccga gcugcugaca cucgugaauc gcaaggugag ccaaagacgg      780

gucgauuucu gcaaggaccc cucugcgauu ggcaaaaagc agguuccuug uuucgccucc      840

augcugacca aaaagcugca cuuuuucccg aaaagcaacu ga                         882


<210>  7080
<211>  882
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_6__Homo_sapiens__AAH00305

<400>  7080
augaguagug caucaggacu aagaagagga cauccagcag gaggagaaga aaacaugaca       60

gaaacagaug cauucuacaa aagagaaaug uucgacccag cagaaaaaua caaaauggau      120

caccgaagaa gaggaauagc auuaauauuc aaucacgaaa gauuuuuuug gcacuuaaca      180

cuaccagaaa gaagaggaac augcgcagac agagacaacc uaacacgaag auuuucagac      240

uuaggauucg aagucaaaug cuucaaugac cuaaaagcag aagaacuacu acuaaaaaua      300

cacgaaguaa gcacaguauc acacgcagau gcagacugcu ucguaugcgu auuuuuauca      360

cacggugaag gaaaucacau auacgcauac gacgcaaaaa uagaaauaca aacacuaaca      420

ggacuauuua aaggagacaa augccacagu uuaguaggaa aaccaaaaau auucauaaua      480

caagcaugca gaggcaauca acacgacgua ccaguaauac cacuagaugu aguagauaac      540

caaacagaaa aacuagacac aaacauaacc gaaguagacg cagcaagcgu auacacacua      600

ccagcaggag cagauuuccu aaugugcuac ucaguagcag aaggauauua cucacacaga      660

gaaacaguaa auggaucaug guacauacaa gaccuuugcg aaaugcuugg aaaauauggg      720

ucaucacuag aauucacaga acuauuaaca cuaguaaaua gaaaaguauc acaaagaaga      780

gucgacuuuu guaaagaccc aucagcaauc ggaaaaaaac aaguacccug uuucgcaagc      840

augcuaacaa aaaaauuaca cuucuucccu aaaucaaacu aa                         882


<210>  7081
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_7__Homo_sapiens__P55210

<400>  7081

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  7082
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_7__Homo_sapiens__AAC50303

<400>  7082
auggcagaug aucagggcug uauugaagag caggggguug aggauucagc aaaugaagau       60

ucaguggaug cuaagccaga ccgguccucg uuuguaccgu cccucuucag uaagaagaag      120

aaaaauguca ccaugcgauc caucaagacc acccgggacc gagugccuac auaucaguac      180

aacaugaauu uugaaaagcu gggcaaaugc aucauaauaa acaacaagaa cuuugauaaa      240

gugacaggua ugggcguucg aaacggaaca gacaaagaug ccgaggcgcu cuucaagugc      300

uuccgaagcc uggguuuuga cgugauuguc uauaaugacu gcucuugugc caagaugcaa      360

gaucugcuua aaaaagcuuc ugaagaggac cauacaaaug ccgccugcuu cgccugcauc      420

cucuuaagcc auggagaaga aaauguaauu uaugggaaag auggugucac accaauaaag      480

gauuugacag cccacuuuag gggggauaga ugcaaaaccc uuuuagagaa acccaaacuc      540

uucuucauuc aggcuugccg agggaccgag cuugaugaug gcauccaggc cgacucgggg      600

cccaucaaug acacagaugc uaauccucga uacaagaucc caguggaagc ugacuuccuc      660

uucgccuauu ccacgguucc aggcuauuac ucguggagga gcccaggaag aggcuccugg      720

uuugugcaag cccucugcuc cauccuggag gagcacggaa aagaccugga aaucaugcag      780

auccucacca gggugaauga cagaguugcc aggcacuuug agucucaguc ugaugaccca      840

cacuuccaug agaagaagca gauccccugu guggucucca ugcucaccaa ggaacucuac      900

uucagucaau ag                                                          912


<210>  7083
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7083
auggccgacg accagggcug caucgaggag cagggggugg aggacagcgc caacgaggac       60

uccgucgacg cgaagcccga ccgcagcucc uucgugccga gccuguucuc caagaagaag      120

aagaacguga ccaugcggag caucaagacc acgcgcgacc ggguccccac cuaccaguac      180

aacaugaacu ucgagaagcu cggcaagugc aucaucauca acaacaagaa cuucgacaag      240

gugaccggga ugggcgugcg caacgggacc gacaaggacg ccgaggcccu guucaagugc      300

uuccgguccc ugggcuucga cgucaucgug uacaacgacu gcagcugcgc caagaugcag      360

gaccuccuga agaaggccuc cgaggaggac cacacgaacg cggccugcuu cgccugcauc      420

cugcucagcc acggcgagga gaacgugauc uacgggaagg acggcgucac ccccaucaag      480

gaccugaccg cccacuuccg cggggaccgg ugcaagaccc ugcucgagaa gcccaagcug      540

uucuucaucc aggcgugccg cggcacggag cuggacgacg ggauccaggc cgacuccggc      600

ccgaucaacg acaccgacgc caacccccgg uacaagaucc ccguggaggc cgacuuccuc      660

uucgccuaca gcaccgugcc cggcuacuac uccuggcgca gcccggggcg gggcuccugg      720

uucguccagg cgcugugcag cauccuggag gagcacggga aggaccucga gaucaugcag      780

auccugaccc gcgugaacga ccggguggcc cgccacuucg agucccagag cgacgacccc      840

cacuuccacg agaagaagca gauccccugc gucgugucca ugcugacgaa ggagcucuac      900

uucagccagu ga                                                          912


<210>  7084
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7084
auggccgacg accagggcug caucgaggag cagggcgucg aggacuccgc caacgaggac       60

uccgucgacg ccaagcccga ccgcuccucc uucguccccu cccucuucuc caagaagaag      120

aagaacguca ccaugcgcuc caucaagacc acccgcgacc gcguccccac cuaccaguac      180

aacaugaacu ucgagaagcu cggcaagugc aucaucauca acaacaagaa cuucgacaag      240

gucaccggca ugggcguccg caacggcacc gacaaggacg ccgaggcccu cuucaagugc      300

uuccgcuccc ucggcuucga cgucaucguc uacaacgacu gcuccugcgc caagaugcag      360

gaccuccuca agaaggccuc cgaggaggac cacaccaacg ccgccugcuu cgccugcauc      420

cuccucuccc acggcgagga gaacgucauc uacggcaagg acggcgucac ccccaucaag      480

gaccucaccg cccacuuccg cggcgaccgc ugcaagaccc uccucgagaa gcccaagcuc      540

uucuucaucc aggccugccg cggcaccgag cucgacgacg gcauccaggc cgacuccggc      600

cccaucaacg acaccgacgc caacccccgc uacaagaucc ccgucgaggc cgacuuccuc      660

uucgccuacu ccaccguccc cggcuacuac uccuggcgcu cccccggccg cggcuccugg      720

uucguccagg cccucugcuc cauccucgag gagcacggca aggaccucga gaucaugcag      780

auccucaccc gcgucaacga ccgcgucgcc cgccacuucg agucccaguc cgacgacccc      840

cacuuccacg agaagaagca gauccccugc gucgucucca ugcucaccaa ggagcucuac      900

uucucccagu ga                                                          912


<210>  7085
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7085
auggccgacg aucagggcug caucgaggaa caaggggugg aggacagcgc uaacgaagau       60

uccgucgacg caaagcccga uagaucuuca uucguuccua gucuguuuag caaaaagaaa      120

aagaauguga ccaugagguc cauuaaaaca acucgggacc gcguaccaac guaccaguau      180

aacaugaauu ucgagaagcu cggaaagugu auaaucauua acaauaaaaa cuuugauaag      240

gugaccggua ugggcguccg aaaugggaca gacaaagaug ccgaagcgcu uuucaagugc      300

uuucguucuc ugggauucga cgugaucguu uacaacgauu guucgugcgc uaaaaugcag      360

gacuuguuaa agaaggccuc agaggaggau cacacuaaug cagccuguuu ugcuugcauu      420

cugcuaagcc auggcgaaga gaacgugauc uaugguaaag acggggucac cccgauaaag      480

gaccucacag cacacuucag aggagauagg uguaaaaccc ugcuugaaaa gcccaaacug      540

uuuuucaucc aggccugccg gggcacugag uuggacgaug gcauucaagc ugacaguggg      600

ccuaucaaug auacagacgc caacccacgc uacaagauuc ccguggaggc ggauuuucuc      660

uucgcauauu ccaccguacc uggauacuau ucuuggagaa gcccagguag gggcuccugg      720

uuuguucagg cccuguguuc aauccuggag gaacauggga aagaccucga aauaaugcag      780

auuuuaacgc gggugaauga ucgcgucgcu cgacacuucg agagucagag cgacgauccc      840

cauuuccacg aaaagaagca aaucccuugc guggugucua ugcugacuaa agagcuuuac      900

uuuucccagu ga                                                          912


<210>  7086
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7086
auggccgacg accagggcug caucgaggag cagggcgugg aggacagcgc caacgaggac       60

agcguggacg ccaagcccga cagaagcagc uucgugccca gccuguucag caagaagaag      120

aagaacguga ccaugagaag caucaagacc accagagaca gagugcccac cuaccaguac      180

aacaugaacu ucgagaagcu gggcaagugc aucaucauca acaacaagaa cuucgacaag      240

gugaccggca ugggcgugag aaacggcacc gacaaggacg ccgaggcccu guucaagugc      300

uucagaagcc ugggcuucga cgugaucgug uacaacgacu gcagcugcgc caagaugcag      360

gaccugcuga agaaggccag cgaggaggac cacaccaacg ccgccugcuu cgccugcauc      420

cugcugagcc acggcgagga gaacgugauc uacggcaagg acggcgugac ccccaucaag      480

gaccugaccg cccacuucag aggcgacaga ugcaagaccc ugcuggagaa gcccaagcug      540

uucuucaucc aggccugcag aggcaccgag cuggacgacg gcauccaggc cgacagcggc      600

cccaucaacg acaccgacgc caaccccaga uacaagaucc ccguggaggc cgacuuccug      660

uucgccuaca gcaccgugcc cggcuacuac agcuggagaa gccccggcag aggcagcugg      720

uucgugcagg cccugugcag cauccuggag gagcacggca aggaccugga gaucaugcag      780

auccugacca gagugaacga cagaguggcc agacacuucg agagccagag cgacgacccc      840

cacuuccacg agaagaagca gauccccugc guggugagca ugcugaccaa ggagcuguac      900

uucagccagu ga                                                          912


<210>  7087
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7087
auggccgacg aucagggcug caucgaggaa caaggggugg aggacagcgc uaacgaagau       60

uccgucgacg ccaagcccga uagaucuagc uucguuccuu cccuguuuuc uaaaaagaaa      120

aagaauguga ccaugcggag cauuaaaaca acgcgcgaca gagugccgac cuaccaguau      180

aacaugaauu ucgagaagcu cggaaagugu aucauuauca acaauaaaaa cuuugauaag      240

gucacaggca ugggggugcg gaauggaacc gacaaagaug cggaagcucu guucaagugc      300

uuucgcuccc uuggcuucga cguuauugug uacaacgauu guucuugcgc caaaaugcag      360

gaccugcuca agaaggccag cgaggaggau cacacaaaug cugccuguuu ugcuugcauc      420

cugcuuuccc auggggaaga gaacgucauc uauggaaaag acggcgugac ccccauuaag      480

gaccugacag cccacuucag aggcgaucgg uguaaaaccc uccuggaaaa gccuaaacug      540

uuuuucaucc aggcgugccg cgggacggag cucgacgaug gcauucaagc cgacagcgga      600

cccaucaaug auaccgacgc uaacccuaga uacaagauuc ccguugaggc cgauuuucug      660

uucgcuuauu cuacagugcc uggguacuau uccuggcgga gcccgggacg cggcucuugg      720

uuuguccagg cccuuuguuc cauccuggag gaacauggga aagaccucga aauuaugcag      780

auccugacca gagugaauga ucggguggcg cgccacuucg agagccaguc ugacgauccc      840

cauuuccacg aaaagaagca aaucccuugc gucguuucca ugcuuacaaa agagcuguac      900

uuuagccagu ga                                                          912


<210>  7088
<211>  912
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_7__Homo_sapiens__AAC50303

<400>  7088
auggcugaug accaaggaug caucgaagaa caaggaguag aagacucagc aaaugaagac       60

agcguagacg caaaaccaga cagaucauca uucguaccau cacuuuucag caaaaaaaaa      120

aaaaacguaa caaugagauc aauaaaaaca acaagagaca gaguaccaac auaccaauau      180

aacaugaauu uugaaaaacu aggaaaaugc auaauaauaa acaacaaaaa cuucgacaaa      240

guaacaggca ugggaguaag aaacggaaca gacaaagacg ccgaagcacu auucaaaugc      300

uucagauccc uaggauucga cguaauaguc uacaacgacu gcucaugugc caaaaugcaa      360

gaccuauuaa aaaaagcauc agaagaagau cacacaaacg cagcaugcuu ugcauguaua      420

cuacuaagcc acggagaaga aaacguaaua uacggaaaag acggaguuac acccauaaaa      480

gauuuaacag cacacuucag aggugacaga ugcaaaacac uacuagaaaa accaaaacuc      540

uucuucauac aagcaugcag aggaacagaa uuagacgacg gaauacaagc agacucagga      600

cccauaaacg acacagacgc aaauccaaga uacaaaauac caguagaagc agauuuccua      660

uucgcauaca gcacaguacc aggauacuac ucauggagau caccaggaag aggaucaugg      720

uucguacaag cacuauguuc aauacuagaa gaacacggaa aagacuuaga aauaaugcaa      780

auacuaacaa gaguuaacga cagaguagca agacacuucg aaucacaaag cgacgacccc      840

cauuuccacg aaaaaaaaca aauaccaugu guaguaagua ugcuaacaaa agaauuauac      900

uucucacaau aa                                                          912


<210>  7089
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__B5BU46

<400>  7089

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Arg Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
                245                 250                 255     


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Gly Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Thr Cys Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 






<210>  7090
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__BAG70096

<400>  7090
auggacuuca gcagaaaucu uuaugauauu ggggaacaac uggacaguga agaucuggcc       60

ucccucaagu uccugagccu ggacuacauu ccgcaaagga agcaagaacc caucaaggau      120

gccuugaugu uauuccagag acuccaggaa aagagaaugu uggaggaaag caaucugucc      180

uuccugaggg agcugcucuu ccgaauuaau agacuggauu ugcugauuac cuaccuaaac      240

acuagaaagg aggagaugga aagggaacuu cagacaccag gcagggcuca aauuucugcc      300

uacaggguca ugcucuauca gauuucagaa gaagugagca gaucagaauu gaggucuuuu      360

aaguuucuuu ugcaagagga aaucuccaaa ugcaaacugg augaugacau gaaccugcug      420

gauauuuuca uagagaugga gaagaggguc auccugggag aaggaaaguu ggacauccug      480

aaaagagucu gugcccaaau caacaagagc cugcugaaga uaaucaacga cuaugaagaa      540

uucagcaaag gggaggaguu guguggggua augacaaucu cggacucucc aagagaacag      600

gauagugaau cacagacuuu ggacaaaguu uaccaaauga aaagcaaacc ucggggauac      660

ugucugauca ucaacaauca caauuuugca aaagcacggg agaaagugcc caaacuucac      720

agcauuaggg acaggaaugg aacacacuug gaugcagggg cuuugaccac gaccuuugaa      780

gagcuucauu uugagaucaa gccccacgau gacugcacag uagagcaaau cuaugagauu      840

uugaaaaucu accaacucau ggaccacagu aacauggacu gcuucaucug cuguauccuc      900

ucccauggag acaagggcau caucuauggc acugauggac aggaggcccc caucuaugag      960

cugacaucuc aguucacugg uuugaagugc ccuucccuug cuggaaaacc caaaguguuu     1020

uuuauucagg cuugucaggg ggauaacuac cagaaaggua uaccuguuga gacugauuca     1080

gaggagcaac ccuauuuaga aauggauuua ucaucaccuc aaacgagaua uaucccggau     1140

gaggcugacu uucugcuggg gauggccacu gugaauaacu guguuuccua ccgaaacccu     1200

gcagagggaa ccugguacau ccagucacuu ugccagagcc ugggagagcg auguccucga     1260

ggcgaugaua uucucaccau ccugacugaa gugaacuaug aaguaagcaa caaggaugac     1320

aagaaaaaca uggggaaaca gaugccucag ccuacuugca cacuaagaaa aaaacuuguc     1380

uucccuucug auuaa                                                      1395


<210>  7091
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7091
auggacuuca gccgcaaccu guacgacauc ggcgagcagc ucgacuccga ggaccuggcc       60

agccugaagu uccucucccu ggacuacauc ccccagcgga agcaggagcc gaucaaggac      120

gcccugaugc uguuccagcg ccugcaggag aagcggaugc uggaggagag caaccucucc      180

uuccugcgcg agcuccucuu ccggaucaac cgccuggacc ugcucaucac cuaccugaac      240

acccggaagg aggagaugga gcgcgagcug cagacgcccg ggcgggcgca gaucagcgcc      300

uaccgcguga ugcucuacca gaucuccgag gaggucagcc gguccgagcu gcgcagcuuc      360

aaguuccugc uccaggagga gaucuccaag ugcaagcugg acgacgacau gaaccugcuc      420

gacaucuuca ucgagaugga gaagcgggug auccugggcg aggggaagcu ggacauccuc      480

aagcgcgugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucuccaagg gcgaggagcu cugcgggguc augaccauca gcgacagccc ccgggagcag      600

gacagcgagu cccagacccu ggacaaggug uaccagauga aguccaagcc ccgcggcuac      660

ugccugauca ucaacaacca caacuucgcc aaggcccggg agaaggugcc gaagcuccac      720

uccauccgcg accggaacgg cacccaccug gacgcggggg cccugacgac caccuucgag      780

gagcuccacu ucgagaucaa gccccacgac gacugcaccg ucgagcagau cuacgagauc      840

cugaagaucu accagcugau ggaccacagc aacauggacu gcuucaucug cugcauccuc      900

agccacggcg acaaggggau caucuacggc acggacgggc aggaggcccc caucuacgag      960

cugaccuccc aguucaccgg ccugaagugc cccagccucg ccggcaagcc gaagguguuc     1020

uucauccagg cgugccaggg ggacaacuac cagaagggca uccccgugga gaccgacucc     1080

gaggagcagc ccuaccugga gauggaccug agcagccccc agacgcgcua caucccggac     1140

gaggccgacu uccuccuggg gauggccacc gucaacaacu gcguguccua ccggaacccc     1200

gccgagggca ccugguacau ccagucccug ugccagagcc ucggcgagcg cugcccccgc     1260

ggggacgaca uccugaccau ccugacggag gugaacuacg aggucuccaa caaggacgac     1320

aagaagaaca ugggcaagca gaugccccag ccgaccugca cccugcggaa gaagcucgug     1380

uuccccagcg acuga                                                      1395


<210>  7092
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7092
auggacuucu cccgcaaccu cuacgacauc ggcgagcagc ucgacuccga ggaccucgcc       60

ucccucaagu uccucucccu cgacuacauc ccccagcgca agcaggagcc caucaaggac      120

gcccucaugc ucuuccagcg ccuccaggag aagcgcaugc ucgaggaguc caaccucucc      180

uuccuccgcg agcuccucuu ccgcaucaac cgccucgacc uccucaucac cuaccucaac      240

acccgcaagg aggagaugga gcgcgagcuc cagacccccg gccgcgccca gaucuccgcc      300

uaccgcguca ugcucuacca gaucuccgag gaggucuccc gcuccgagcu ccgcuccuuc      360

aaguuccucc uccaggagga gaucuccaag ugcaagcucg acgacgacau gaaccuccuc      420

gacaucuuca ucgagaugga gaagcgcguc auccucggcg agggcaagcu cgacauccuc      480

aagcgcgucu gcgcccagau caacaagucc cuccucaaga ucaucaacga cuacgaggag      540

uucuccaagg gcgaggagcu cugcggcguc augaccaucu ccgacucccc ccgcgagcag      600

gacuccgagu cccagacccu cgacaagguc uaccagauga aguccaagcc ccgcggcuac      660

ugccucauca ucaacaacca caacuucgcc aaggcccgcg agaagguccc caagcuccac      720

uccauccgcg accgcaacgg cacccaccuc gacgccggcg cccucaccac caccuucgag      780

gagcuccacu ucgagaucaa gccccacgac gacugcaccg ucgagcagau cuacgagauc      840

cucaagaucu accagcucau ggaccacucc aacauggacu gcuucaucug cugcauccuc      900

ucccacggcg acaagggcau caucuacggc accgacggcc aggaggcccc caucuacgag      960

cucaccuccc aguucaccgg ccucaagugc cccucccucg ccggcaagcc caaggucuuc     1020

uucauccagg ccugccaggg cgacaacuac cagaagggca uccccgucga gaccgacucc     1080

gaggagcagc ccuaccucga gauggaccuc uccucccccc agacccgcua cauccccgac     1140

gaggccgacu uccuccucgg cauggccacc gucaacaacu gcgucuccua ccgcaacccc     1200

gccgagggca ccugguacau ccagucccuc ugccaguccc ucggcgagcg cugcccccgc     1260

ggcgacgaca uccucaccau ccucaccgag gucaacuacg aggucuccaa caaggacgac     1320

aagaagaaca ugggcaagca gaugccccag cccaccugca cccuccgcaa gaagcucguc     1380

uuccccuccg acuga                                                      1395


<210>  7093
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7093
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuugcc       60

ucucugaagu uuuugucauu agacuauauu ccccaaagga aacaggagcc uauaaaggau      120

gcucugaugc uauuccagcg gcuccaggaa aaacgcaugc uggaggaaag uaaucuuagc      180

uuucugcgag agcucuuguu ccguaucaac agacuggacc ugcucauuac cuacuuaaau      240

acaaggaagg aggaaaugga gcgggaacug caaacuccag ggcgcgcaca gaucuccgcc      300

uauagaguga ugcuuuacca gauuucugag gaggucucga ggucagaauu gcggagcuuu      360

aaauuccugc uacaggagga aaucaguaag ugcaagcucg augacgauau gaaccugcuu      420

gacauauuua ucgagaugga aaaacgcguu auucugggag aggguaaguu ggauauccuc      480

aaacgagugu gugcgcaaau uaauaagucc cuguuaaaaa ucauaaacga cuaugaggag      540

uucucuaagg gcgaggaacu gugcggggua augacgauua gcgauucccc gagagagcag      600

gacucagaaa gucagacccu cgacaaggug uaccagauga aaagcaagcc caggggauau      660

ugucuuauca uuaauaacca caauuuugcu aaagcccggg agaagguccc uaaacugcau      720

ucuauccgug aucgcaacgg cacacacuug gacgccggug cacuaacuac cacauucgag      780

gaacugcauu uugagaucaa gccacacgau gacugcaccg uggaacaaau uuacgagaua      840

cucaaaaucu accagcugau ggaucauucc aauauggacu guuucauuug cuguauccuu      900

ucacacgggg auaagggaau aauuuauggc acugacggcc aggaagcucc caucuacgag      960

cugacaagcc aauuuaccgg guugaagugc ccuagucucg caggaaaacc aaagguuuuc     1020

uucauccagg ccugucaggg ugauaacuau cagaaaggca uucccgugga gacggacucu     1080

gaagaacaac cuuaccugga aauggauuua uccagcccac agacuagaua uaucccggac     1140

gaggcugacu uucugcuagg gauggccacc gucaauaacu gcgugucgua caggaauccc     1200

gcggagggaa caugguauau ucagucucuc ugucaguccc ugggcgaacg gugcccucga     1260

ggugaugaca uacuuacuau cuugaccgag guaaacuacg aaguuucaaa caaggaugac     1320

aaaaagaaua uggggaagca aaugccacag cccacaugca cccugcgcaa aaagcucgug     1380

uucccuagug auuga                                                      1395


<210>  7094
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7094
auggacuuca gcagaaaccu guacgacauc ggcgagcagc uggacagcga ggaccuggcc       60

agccugaagu uccugagccu ggacuacauc ccccagagaa agcaggagcc caucaaggac      120

gcccugaugc uguuccagag acugcaggag aagagaaugc uggaggagag caaccugagc      180

uuccugagag agcugcuguu cagaaucaac agacuggacc ugcugaucac cuaccugaac      240

accagaaagg aggagaugga gagagagcug cagacccccg gcagagccca gaucagcgcc      300

uacagaguga ugcuguacca gaucagcgag gaggugagca gaagcgagcu gagaagcuuc      360

aaguuccugc ugcaggagga gaucagcaag ugcaagcugg acgacgacau gaaccugcug      420

gacaucuuca ucgagaugga gaagagagug auccugggcg agggcaagcu ggacauccug      480

aagagagugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucagcaagg gcgaggagcu gugcggcgug augaccauca gcgacagccc cagagagcag      600

gacagcgaga gccagacccu ggacaaggug uaccagauga agagcaagcc cagaggcuac      660

ugccugauca ucaacaacca caacuucgcc aaggccagag agaaggugcc caagcugcac      720

agcaucagag acagaaacgg cacccaccug gacgccggcg cccugaccac caccuucgag      780

gagcugcacu ucgagaucaa gccccacgac gacugcaccg uggagcagau cuacgagauc      840

cugaagaucu accagcugau ggaccacagc aacauggacu gcuucaucug cugcauccug      900

agccacggcg acaagggcau caucuacggc accgacggcc aggaggcccc caucuacgag      960

cugaccagcc aguucaccgg ccugaagugc cccagccugg ccggcaagcc caagguguuc     1020

uucauccagg ccugccaggg cgacaacuac cagaagggca uccccgugga gaccgacagc     1080

gaggagcagc ccuaccugga gauggaccug agcagccccc agaccagaua cauccccgac     1140

gaggccgacu uccugcuggg cauggccacc gugaacaacu gcgugagcua cagaaacccc     1200

gccgagggca ccugguacau ccagagccug ugccagagcc ugggcgagag augccccaga     1260

ggcgacgaca uccugaccau ccugaccgag gugaacuacg aggugagcaa caaggacgac     1320

aagaagaaca ugggcaagca gaugccccag cccaccugca cccugagaaa gaagcuggug     1380

uuccccagcg acuga                                                      1395


<210>  7095
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7095
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuggcc       60

ucucuuaagu uucugagccu cgacuauauu ccccaacgga aacaggagcc uaucaaggau      120

gcucugaugc uuuuccagcg ccugcaggag aaaagaaugc ucgaggaauc caaucugucu      180

uuucugcggg agcuccuguu ccgcauuaac agacuugacc ugcucaucac cuaccugaau      240

acacggaagg aggaaaugga gcgcgaacuu caaacgccgg ggagagccca gauuagcgcg      300

uaucggguga ugcuguacca gaucuccgag gaggucucuc gcagcgaacu cagauccuuu      360

aaauuccugc ugcaggagga aaucagcaag ugcaagcucg augacgauau gaaccugcuu      420

gacauuuuua ucgagaugga aaaacggguu auucugggag agggcaagcu cgauauccug      480

aaacgcgugu gugcucaaau uaauaagucu cuucugaaaa ucauuaacga cuaugaggag      540

uucuccaagg gggaagaacu cugcggagug augaccauca gcgauucucc cagagagcag      600

gacuccgaaa gccagacacu ggacaagguc uaccagauga aaucuaagcc ucggggcuau      660

ugucugauca uuaauaacca caauuuugcc aaagcccgcg agaaggugcc caaacuccau      720

uccaucagag aucggaacgg gacccaccug gacgcuggag cccuuacaac cacauucgag      780

gaacugcauu uugagauuaa gccucacgau gacugcaccg uugaacaaau cuacgagauu      840

cucaaaaucu accagcugau ggaucauagc aauauggacu guuucaucug cuguauucuu      900

ucccacggcg auaagggcau cauuuauggg acggacggac aggaagcucc caucuacgag      960

cugaccucuc aauuuacagg ccucaagugc ccuagccugg ccgggaaacc gaagguguuc     1020

uucauucagg cgugucaggg agauaacuau cagaaaggca uccccgucga gaccgacucc     1080

gaagaacaac cuuaccugga aauggaucuc agcucucccc agacaagaua uaucccugac     1140

gaggccgacu uucugcuugg gauggcuacc gugaauaacu gcguuuccua ccgcaauccc     1200

gccgagggaa cgugguauau ucagagccug ugucagucuc ucggcgaacg gugcccgaga     1260

ggcgaugaca uccugacaau ucugaccgag gugaacuacg aagucagcaa caaggaugac     1320

aaaaagaaua uggggaagca aaugccucag cccacaugca cccuucgcaa aaagcucgug     1380

uucccuuccg auuga                                                      1395


<210>  7096
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_8__Homo_sapiens__BAG70096

<400>  7096
auggacuucu ccagaaacuu auacgacaua ggagaacaau uagauucuga agaccucgcc       60

ucacuaaaau uccuaucauu agacuauaua ccacaaagaa aacaagaacc uauaaaagau      120

gcauuaaugc ucuuccaaag auuacaagaa aaacgaaugc uagaagaaag uaacuuauca      180

uucuuaaggg aacuauuauu ccgcauaaac cgucuagacc uucuaauaac auaucuaaac      240

acuagaaaag aagaaaugga acgagaacua caaacaccag gaagagcaca aauaucagca      300

uauagaguaa uguuauauca aauaagcgaa gaaguaagua gaucagaauu aagaagcuuc      360

aaauucuuac uacaagaaga aauaucaaaa uguaaacucg acgacgauau gaauuuacua      420

gacauauuca ucgaaaugga aaaaagagua auacuaggcg aaggaaaacu agacauauua      480

aaacgaguau gugcacaaau caauaaaucg cuauuaaaaa uuauaaacga uuacgaagaa      540

uucagcaaag gcgaagaacu augcggagua augacaauau cagacucacc aagagaacaa      600

gacucagaau cacaaacucu agacaaaguu uaucaaauga aauccaaacc acgaggauau      660

ugccuaauaa uaaacaauca caacuucgca aaagccagag aaaaaguacc aaaacuccac      720

ucaauaagag acagaaacgg aacacaccua gacgccggag cacuaacaac cacauucgaa      780

gaacuacacu ucgaaauaaa accacacgac gacuguaccg uagaacaaau auaugaaaua      840

uuaaaaaucu accaauuaau ggaucacuca aauauggacu gcuucauaug cugcaucuug      900

ucacacggag acaaagggau cauuuacgga acagacggac aagaagcacc aauauacgaa      960

cuaaccucac aauucacagg acucaaaugc ccaucauuag caggcaaacc aaaagucuuu     1020

uucauccaag caugccaagg cgauaauuac caaaaaggaa uaccaguaga aacagacagc     1080

gaagaacaac cauaccuaga aauggaucuc ucaucacccc aaacaagaua uauaccagau     1140

gaagcagacu uccuacuagg cauggcaacu guaaacaacu gcguaagcua cagaaaccca     1200

gcggaaggaa ccugguacau acaaucucua ugccaaucau uaggagaaag augcccaaga     1260

ggagacgaca uacuaacaau uuuaacagaa guaaacuaug aaguauccaa uaaagacgau     1320

aaaaaaaaua uggguaaaca aaugccacaa ccaacaugca cccuaagaaa aaaauuagua     1380

uucccuagug auuaa                                                      1395


<210>  7097
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__B6CGU5

<400>  7097

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Ala Leu Thr Thr Thr Phe Glu Glu 
            180                 185                 190         


Leu His Phe Glu Ile Lys Pro His His Asp Cys Thr Val Glu Gln Ile 
        195                 200                 205             


Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp 
    210                 215                 220                 


Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr 
225                 230                 235                 240 


Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe 
                245                 250                 255     


Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe 
            260                 265                 270         


Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu 
        275                 280                 285             


Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro 
    290                 295                 300                 


Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala 
305                 310                 315                 320 


Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp 
                325                 330                 335     


Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly 
            340                 345                 350         


Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn 
        355                 360                 365             


Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe 
    370                 375                 380                 


Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
385                 390                 395 


<210>  7098
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__ABX09989

<400>  7098
auggacuuca gcagaaaucu uuaugauauu ggggaacaac uggacaguga agaucuggcc       60

ucccucaagu uccugagccu ggacuacauu ccgcaaagga agcaagaacc caucaaggau      120

gccuugaugu uauuccagag acuccaggaa aagagaaugu uggaggaaag caaucugucc      180

uuccugaagg agcugcucuu ccgaauuaau agacuggauu ugcugauuac cuaccuaaac      240

acuagaaagg aggagaugga aagggaacuu cagacaccag gcagggcuca aauuucugcc      300

uacaggguca ugcucuauca gauuucagaa gaagugagca gaucagaauu gaggucuuuu      360

aaguuucuuu ugcaagagga aaucuccaaa ugcaaacugg augaugacau gaaccugcug      420

gauauuuuca uagagaugga gaagaggguc auccugggag aaggaaaguu ggacauccug      480

aaaagagucu gugcccaaau caacaagagc cugcugaaga uaaucaacga cuaugaagaa      540

uucagcaaag gggcuuugac cacgaccuuu gaagagcuuc auuuugagau caagccccac      600

caugacugca caguagagca aaucuaugag auuuugaaaa ucuaccaacu cauggaccac      660

aguaacaugg acugcuucau cugcuguauc cucucccaug gagacaaggg caucaucuau      720

ggcacugaug gacaggaggc ccccaucuau gagcugacau cucaguucac ugguuugaag      780

ugcccuuccc uugcuggaaa acccaaagug uuuuuuauuc aggcuuguca gggggauaac      840

uaccagaaag guauaccugu ugagacugau ucagaggagc aacccuauuu agaaauggau      900

uuaucaucac cucaaacgag auauaucccg gaugaggcug acuuucugcu ggggauggcc      960

acugugaaua acuguguuuc cuaccgaaac ccugcagagg gaaccuggua cauccaguca     1020

cuuugccaga gccugagaga gcgauguccu cgaggcgaug auauucucac cauccugacu     1080

gaagugaacu augaaguaag caacaaggau gacaagaaaa acauggggaa acagaugccu     1140

cagccuacuu ucacacuaag aaaaaaacuu gucuucccuu cugauuga                  1188


<210>  7099
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7099
auggacuuca gccgcaaccu guacgacauc ggcgagcagc ucgacuccga ggaccuggcc       60

agccugaagu uccucucccu ggacuacauc ccccagcgga agcaggagcc gaucaaggac      120

gcccugaugc uguuccagcg ccugcaggag aagcggaugc uggaggagag caaccucucc      180

uuccugaagg agcuccucuu ccgcaucaac cggcuggacc ugcucaucac cuaccugaac      240

acccgcaagg aggagaugga gcgggagcug cagacgcccg ggcgcgcgca gaucagcgcc      300

uaccggguga ugcucuacca gaucuccgag gaggucagcc gcuccgagcu gcggagcuuc      360

aaguuccugc uccaggagga gaucuccaag ugcaagcugg acgacgacau gaaccugcuc      420

gacaucuuca ucgagaugga gaagcgcgug auccugggcg aggggaagcu ggacauccuc      480

aagcgggugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucuccaagg gcgcccucac caccaccuuc gaggagcugc acuucgagau caagccccac      600

cacgacugca cggucgagca gaucuacgag auccugaaga ucuaccagcu cauggaccac      660

agcaacaugg acugcuucau cugcugcauc cugucccacg gggacaaggg caucaucuac      720

ggcaccgacg ggcaggaggc ccccaucuac gagcugacca gccaguucac cggccucaag      780

ugcccguccc uggcggggaa gcccaaggug uucuucaucc aggccugcca gggcgacaac      840

uaccagaagg ggauccccgu ggagacggac agcgaggagc agcccuaccu ggagauggac      900

cucuccagcc cgcagacccg cuacaucccc gacgaggccg acuuccugcu gggcauggcc      960

accgucaaca acugcgugag cuaccggaac cccgcggagg gcaccuggua cauccagucc     1020

cucugccaga gccugcgcga gcggugcccc cgcggggacg acauccugac gauccucacc     1080

gaggugaacu acgaggucuc caacaaggac gacaagaaga acaugggcaa gcagaugccg     1140

cagcccaccu ucacccugcg gaagaagcug guguucccca gcgacuga                  1188


<210>  7100
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7100
auggacuucu cccgcaaccu cuacgacauc ggcgagcagc ucgacuccga ggaccucgcc       60

ucccucaagu uccucucccu cgacuacauc ccccagcgca agcaggagcc caucaaggac      120

gcccucaugc ucuuccagcg ccuccaggag aagcgcaugc ucgaggaguc caaccucucc      180

uuccucaagg agcuccucuu ccgcaucaac cgccucgacc uccucaucac cuaccucaac      240

acccgcaagg aggagaugga gcgcgagcuc cagacccccg gccgcgccca gaucuccgcc      300

uaccgcguca ugcucuacca gaucuccgag gaggucuccc gcuccgagcu ccgcuccuuc      360

aaguuccucc uccaggagga gaucuccaag ugcaagcucg acgacgacau gaaccuccuc      420

gacaucuuca ucgagaugga gaagcgcguc auccucggcg agggcaagcu cgacauccuc      480

aagcgcgucu gcgcccagau caacaagucc cuccucaaga ucaucaacga cuacgaggag      540

uucuccaagg gcgcccucac caccaccuuc gaggagcucc acuucgagau caagccccac      600

cacgacugca ccgucgagca gaucuacgag auccucaaga ucuaccagcu cauggaccac      660

uccaacaugg acugcuucau cugcugcauc cucucccacg gcgacaaggg caucaucuac      720

ggcaccgacg gccaggaggc ccccaucuac gagcucaccu cccaguucac cggccucaag      780

ugccccuccc ucgccggcaa gcccaagguc uucuucaucc aggccugcca gggcgacaac      840

uaccagaagg gcauccccgu cgagaccgac uccgaggagc agcccuaccu cgagauggac      900

cucuccuccc cccagacccg cuacaucccc gacgaggccg acuuccuccu cggcauggcc      960

accgucaaca acugcgucuc cuaccgcaac cccgccgagg gcaccuggua cauccagucc     1020

cucugccagu cccuccgcga gcgcugcccc cgcggcgacg acauccucac cauccucacc     1080

gaggucaacu acgaggucuc caacaaggac gacaagaaga acaugggcaa gcagaugccc     1140

cagcccaccu ucacccuccg caagaagcuc gucuuccccu ccgacuga                  1188


<210>  7101
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7101
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuugcc       60

ucucugaagu uuuugucauu agacuauauu ccccaaagga aacaggagcc uauaaaggau      120

gcucugaugc uauuccagcg gcuccaggaa aaacgcaugc uggaggaaag uaaucuuagc      180

uuucugaagg agcucuuguu ccgaaucaac cgucuggacc ugcucauuac cuacuuaaau      240

acaagaaaag aggaaaugga gagggaacug caaacuccag ggcgggcaca gaucuccgcc      300

uaucgcguga ugcuuuacca gauuucugag gaggucucga gaucagaauu gaggagcuuu      360

aaguuccugc uacaggagga aaucaguaag ugcaaacucg augacgauau gaaccugcuu      420

gacauauuua ucgagaugga aaagcggguu auucugggag aggguaaauu ggauauccuc      480

aagcgcgugu gugcgcaaau uaauaaaucc cuguuaaaga ucauaaacga cuaugaggag      540

uucucuaagg gcgcucugac gaccacauuu gaggaacucc acuucgagau uaaaccgcau      600

cacgauugca cuguagaaca gaucuacgag auucuuaaga ucuaucagcu gauggaccau      660

agcaauaugg acuguuuuau cugcuguauu uugucccacg gggauaaagg aauaaucuac      720

ggcaccgacg gucaggaggc ccccauuuac gaacuaacau cacaauucac cgggcugaag      780

ugcccuaguc ucgcaggaaa accaaaggug uuuuucaucc aggccuguca gggcgauaac      840

uaucaaaaag gcauacccgu cgagacugac agcgaagaac agccuuaccu ggaaauggau      900

cuuucuuccc cacagacacg auauauuccc gacgaggcug auuuccuguu ggggauggca      960

accgugaaua acugcguuuc auacagaaau ccugccgagg gaacguggua uauccagagc     1020

cucugucaaa gucugaggga acggugccca cguggugacg auaucuuaac uauucugacc     1080

gaggugaacu acgaagucuc uaauaaggac gauaagaaaa acaugggcaa gcagaugccg     1140

cagcccacau uuacucuacg caaaaagcuc guguucccuu ccgacuga                  1188


<210>  7102
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7102
auggacuuca gcagaaaccu guacgacauc ggcgagcagc uggacagcga ggaccuggcc       60

agccugaagu uccugagccu ggacuacauc ccccagagaa agcaggagcc caucaaggac      120

gcccugaugc uguuccagag acugcaggag aagagaaugc uggaggagag caaccugagc      180

uuccugaagg agcugcuguu cagaaucaac agacuggacc ugcugaucac cuaccugaac      240

accagaaagg aggagaugga gagagagcug cagacccccg gcagagccca gaucagcgcc      300

uacagaguga ugcuguacca gaucagcgag gaggugagca gaagcgagcu gagaagcuuc      360

aaguuccugc ugcaggagga gaucagcaag ugcaagcugg acgacgacau gaaccugcug      420

gacaucuuca ucgagaugga gaagagagug auccugggcg agggcaagcu ggacauccug      480

aagagagugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucagcaagg gcgcccugac caccaccuuc gaggagcugc acuucgagau caagccccac      600

cacgacugca ccguggagca gaucuacgag auccugaaga ucuaccagcu gauggaccac      660

agcaacaugg acugcuucau cugcugcauc cugagccacg gcgacaaggg caucaucuac      720

ggcaccgacg gccaggaggc ccccaucuac gagcugacca gccaguucac cggccugaag      780

ugccccagcc uggccggcaa gcccaaggug uucuucaucc aggccugcca gggcgacaac      840

uaccagaagg gcauccccgu ggagaccgac agcgaggagc agcccuaccu ggagauggac      900

cugagcagcc cccagaccag auacaucccc gacgaggccg acuuccugcu gggcauggcc      960

accgugaaca acugcgugag cuacagaaac cccgccgagg gcaccuggua cauccagagc     1020

cugugccaga gccugagaga gagaugcccc agaggcgacg acauccugac cauccugacc     1080

gaggugaacu acgaggugag caacaaggac gacaagaaga acaugggcaa gcagaugccc     1140

cagcccaccu ucacccugag aaagaagcug guguucccca gcgacuga                  1188


<210>  7103
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7103
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuggcc       60

ucucuuaagu uucugagccu cgacuauauu ccccaacgga aacaggagcc uaucaaggau      120

gcucugaugc uuuuccagcg ccugcaggag aaaagaaugc ucgaggaauc caaucugucu      180

uuucugaagg agcuccuguu ccggauuaac cgccuugacc ugcucaucac cuaccugaau      240

acaagaaaag aggaaaugga gcgggaacuu caaacgccgg ggcgcgccca gauuagcgcg      300

uauagaguga ugcuguacca gaucuccgag gaggucucuc ggagcgaacu ccgcuccuuu      360

aaguuccugc ugcaggagga aaucagcaag ugcaaacucg augacgauau gaaccugcuu      420

gacauuuuua ucgagaugga aaagagaguu auucugggag agggcaaacu cgauauccug      480

aagcgggugu gugcucaaau uaauaaaucu cuucugaaga ucauuaacga cuaugaggag      540

uucuccaagg gggcccucac cacaaccuuu gaagaacugc acuucgagau caaaccccau      600

cacgauugca caguggaaca gaucuacgag auucugaaga ucuaucagcu cauggaccau      660

agcaauaugg acuguuuuau uugcuguauc cugucucacg gagauaaagg cauuaucuac      720

gggaccgacg gacaggaggc cccuaucuac gaacuuacau cccaauucac cggccugaag      780

ugccccagcc ucgcuggcaa accuaagguc uuuuucauuc aggccuguca gggggauaac      840

uaucaaaaag gaauccccgu ggagacggac ucugaagaac agccuuaccu ggaaauggau      900

cuuuccagcc cgcagacccg cuauauuccc gacgaggcug auuuccugcu cggcauggcc      960

acaguuaaua acugcguguc cuacagaaau ccugcggagg ggaccuggua uauccagucu     1020

cugugucaaa gccugcggga acgcugcccc agaggagacg auauucucac aauccugacc     1080

gaggucaacu acgaaguguc caauaaggac gauaagaaaa acaugggcaa gcagaugccu     1140

cagcccacgu uuacacuucg gaaaaagcug guuuucccga gcgacuga                  1188


<210>  7104
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_8__Homo_sapiens__ABX09989

<400>  7104
auggacuucu ccagaaaucu auacgacaua ggagaacaac uagacucaga agaccuagcu       60

ucucuaaaau uucuaucacu agacuacaua ccacaacgaa aacaagaacc aauaaaagac      120

gcauuaaugc uauuccaaag auuacaagaa aaaagaaugc uagaagaauc aaaucuauca      180

uuccuaaaag aacuacuauu uagaauaaac agacucgacc uccuaauaac auaccuaaac      240

acaagaaaag aagaaaugga aagagaacuc caaaccccag gaagagcaca aauaucagca      300

uaccgaguaa ugcuauauca aauaucagaa gaagucucac gaucagaacu acgauccuuc      360

aaauuccuau uacaagaaga aauaucaaaa ugcaaacuag acgacgacau gaacuuacua      420

gacauauuua uagaaaugga aaaaagagua auacuaggag agggcaaacu cgacauacua      480

aaaagaguuu gcgcccaaau uaauaaauca cugcuaaaaa uaaucaauga cuacgaagaa      540

uucucaaaag gagcacuaac cacuacauuc gaagaacugc acuucgaaau aaaaccacac      600

cacgacugua caguagaaca aauauacgaa auauuaaaaa uauaccaacu gauggaucau      660

uccaauaugg acugcuuuau augcugcaua cucucacacg gagacaaagg aauaauauac      720

ggaacagacg gucaagaagc accaauauac gaacuuacau cacaauucac aggauuaaaa      780

ugcccaucau uagccggaaa accaaaagua uucuucaucc aagcaugcca aggcgacaac      840

uaccaaaaag gcauaccagu agaaacagac agugaagaac aaccauacuu agaaauggau      900

uuauccucac cccaaacaag auauauaccc gacgaagcag acuucuuacu aggaauggca      960

acuguuaaua acugcguuuc auauagaaau ccagcagaag gaacauggua uauacaauca     1020

uuaugccaaa gccuaagaga aagaugcccc agaggagacg auauacuuac aauacuaaca     1080

gaaguaaacu acgaaguuuc caacaaagac gacaaaaaaa acaugggcaa acaaaugccu     1140

caaccaacau ucacuuuaag aaaaaaauua guauucccua gcgauuaa                  1188


<210>  7105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__C3S3G0

<400>  7105

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Thr Cys Trp Ile Phe Ser 
            100                 105             


<210>  7106
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__ACF93415

<400>  7106
auggacuuca gcagaaaucu uuaugauauu ggggaacaac uggacaguga agaucuggcc       60

ucccucaagu uccugagccu ggacuacauu ccgcaaagga agcaagaacc caucaaggau      120

gccuugaugu uauuccagag acuccaggaa aagagaaugu uggaggaaag caaucugucc      180

uuccugaagg agcugcucuu ccgaauuaau agacuggauu ugcugauuac cuaccuaaac      240

acuagaaagg aggagaugga aagggaacuu cagacaccag gcagggcuca aauuucugcc      300

uacagaaccu gcuggauauu uucauag                                          327


<210>  7107
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7107
auggacuuca gccgcaaccu guacgacauc ggcgagcagc ucgacuccga ggaccuggcc       60

agccugaagu uccucucccu ggacuacauc ccccagcgga agcaggagcc gaucaaggac      120

gcccugaugc uguuccagcg ccugcaggag aagcggaugc uggaggagag caaccucucc      180

uuccugaagg agcuccucuu ccgcaucaac cggcuggacc ugcucaucac cuaccugaac      240

acccgcaagg aggagaugga gcgggagcug cagacgcccg ggcgcgcgca gaucagcgcc      300

uaccggaccu gcuggaucuu cuccuga                                          327


<210>  7108
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7108
auggacuucu cccgcaaccu cuacgacauc ggcgagcagc ucgacuccga ggaccucgcc       60

ucccucaagu uccucucccu cgacuacauc ccccagcgca agcaggagcc caucaaggac      120

gcccucaugc ucuuccagcg ccuccaggag aagcgcaugc ucgaggaguc caaccucucc      180

uuccucaagg agcuccucuu ccgcaucaac cgccucgacc uccucaucac cuaccucaac      240

acccgcaagg aggagaugga gcgcgagcuc cagacccccg gccgcgccca gaucuccgcc      300

uaccgcaccu gcuggaucuu cuccuga                                          327


<210>  7109
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7109
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuugcc       60

ucucugaagu uuuugucauu agacuauauu ccccaaagga aacaggagcc uauaaaggau      120

gcucugaugc uauuccagcg gcuccaggaa aaacgcaugc uggaggaaag uaaucuuagc      180

uuucugaagg aguugcucuu ucgaaucaac cgucuggacc ugcucauuac cuacuuaaau      240

acaagaaaag aggaaaugga gagggaacug caaacuccag ggcgggcaca gaucuccgcc      300

uaucgcacgu gcuggauuuu cucuuga                                          327


<210>  7110
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7110
auggacuuca gcagaaaccu guacgacauc ggcgagcagc uggacagcga ggaccuggcc       60

agccugaagu uccugagccu ggacuacauc ccccagagaa agcaggagcc caucaaggac      120

gcccugaugc uguuccagag acugcaggag aagagaaugc uggaggagag caaccugagc      180

uuccugaagg agcugcuguu cagaaucaac agacuggacc ugcugaucac cuaccugaac      240

accagaaagg aggagaugga gagagagcug cagacccccg gcagagccca gaucagcgcc      300

uacagaaccu gcuggaucuu cagcuga                                          327


<210>  7111
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7111
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuggcc       60

ucucuuaagu uucugagccu cgacuauauu ccccaacgga aacaggagcc uaucaaggau      120

gcucugaugc uuuuccagcg ccugcaggag aaaagaaugc ucgaagaauc caaucugucu      180

uuucugaagg agcuccuguu ccggauuaac cgccuugacc ugcucaucac cuaccugaau      240

acaagaaaag aggaaaugga gcgggaacuu caaacgccgg ggcgcgccca gauuagcgcg      300

uauagaaccu gcuggaucuu uuccuga                                          327


<210>  7112
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_8__Homo_sapiens__ACF93415

<400>  7112
auggacuucu caagaaaccu auacgacaua ggagaacaac uagacucaga agaccuagca       60

ucacuaaaau uccuaucacu agacuacaua ccacaaagaa aacaagaacc aauaaaagac      120

gcacuaaugc uauuccaaag acuacaagaa aaaagaaugc uagaagaauc aaaccuauca      180

uuccuaaaag aacuacuauu cagaauaaac agacuagacc uacuaauaac auaccuaaac      240

acaagaaaag aagaaaugga aagagaacua caaacaccag gaagagcaca aauaucagca      300

uacagaacau gcuggauauu cucauaa                                          327


<210>  7113
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__Q14790

<400>  7113

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 
        195                 200                 205             


Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 
    210                 215                 220                 


Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 
225                 230                 235                 240 


Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 
                245                 250                 255     


Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 
            260                 265                 270         


Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 
        275                 280                 285             


Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 
    290                 295                 300                 


Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 
305                 310                 315                 320 


Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 
                325                 330                 335     


Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 
        355                 360                 365             


Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 
    370                 375                 380                 


Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 
385                 390                 395                 400 


Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 
                405                 410                 415     


Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 
            420                 425                 430         


Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 
        435                 440                 445             


Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 
    450                 455                 460                 


Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
465                 470                 475                 


<210>  7114
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_8__Homo_sapiens__CAA66853

<400>  7114
auggacuuca gcagaaaucu uuaugauauu ggggaacaac uggacaguga agaucuggcc       60

ucccucaagu uccugagccu ggacuacauu ccgcaaagga agcaagaacc caucaaggau      120

gccuugaugu uauuccagag acuccaggaa aagagaaugu uggaggaaag caaucugucc      180

uuccugaagg agcugcucuu ccgaauuaau agacuggauu ugcugauuac cuaccuaaac      240

acuagaaagg aggagaugga aagggaacuu cagacaccag gcagggcuca aauuucugcc      300

uacaggguca ugcucuauca gauuucagaa gaagugagca gaucagaauu gaggucuuuu      360

aaguuucuuu ugcaagagga aaucuccaaa ugcaaacugg augaugacau gaaccugcug      420

gauauuuuca uagagaugga gaagaggguc auccugggag aaggaaaguu ggacauccug      480

aaaagagucu gugcccaaau caacaagagc cugcugaaga uaaucaacga cuaugaagaa      540

uucagcaaag agagaagcag cagccuugaa ggaaguccug augaauuuuc aaauggggag      600

gaguugugug ggguaaugac aaucucggac ucuccaagag aacaggauag ugaaucacag      660

acuuuggaca aaguuuacca aaugaaaagc aaaccucggg gauacugucu gaucaucaac      720

aaucacaauu uugcaaaagc acgggagaaa gugcccaaac uucacagcau uagggacagg      780

aauggaacac acuuggaugc aggggcuuug accacgaccu uugaagagcu ucauuuugag      840

aucaagcccc acgaugacug cacaguagag caaaucuaug agauuuugaa aaucuaccaa      900

cucauggacc acaguaacau ggacugcuuc aucugcugua uccucuccca uggagacaaa      960

ggcaucaucu auggcacuga uggacaggag gcccccaucu augagcugac aucucaguuc     1020

acugguuuga agugcccuuc ccuugcugga aaacccaaag uguuuuuuau ucaggcuugu     1080

cagggggaua acuaccagaa agguauaccu guugagacug auucagagga gcaacccuau     1140

uuagaaaugg auuuaucauc accucaaacg agauauaucc cggaugaggc ugacuuucug     1200

cuggggaugg ccacugugaa uaacuguguu uccuaccgaa acccugcaga gggaaccugg     1260

uacauccagu cacuuugcca gagccugaga gagcgauguc cucgaggcga ugauauucuc     1320

accauccuga cugaagugaa cuaugaagua agcaacaagg augacaagaa aaacaugggg     1380

aaacagaugc cucagccuac uuucacacua agaaaaaaac uugucuuccc uucugauuga     1440


<210>  7115
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7115
auggacuuca gccgcaaccu guacgacauc ggcgagcagc ucgacuccga ggaccuggcc       60

agccugaagu uccucucccu ggacuacauc ccccagcgga agcaggagcc gaucaaggac      120

gcccugaugc uguuccagcg ccugcaggag aagcggaugc uggaggagag caaccucucc      180

uuccugaagg agcuccucuu ccgcaucaac cggcuggacc ugcucaucac cuaccugaac      240

acccgcaagg aggagaugga gcgggagcug cagacgcccg ggcgcgcgca gaucagcgcc      300

uaccggguga ugcucuacca gaucuccgag gaggucagcc gcuccgagcu gcggagcuuc      360

aaguuccugc uccaggagga gaucuccaag ugcaagcugg acgacgacau gaaccugcuc      420

gacaucuuca ucgagaugga gaagcgcgug auccugggcg aggggaagcu ggacauccuc      480

aagcgggugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucuccaagg agcgcagcuc cagccucgag ggcucccccg acgaguucag caacggggag      600

gagcugugcg gcgucaugac caucuccgac agcccccggg agcaggacag cgagucccag      660

acccuggaca agguguacca gaugaagucc aagccgcgcg gcuacugccu caucaucaac      720

aaccacaacu ucgccaaggc ccgggagaag gugcccaagc ugcacagcau ccgcgaccgg      780

aacgggaccc accuggacgc gggcgcccuc acgaccaccu ucgaggagcu gcacuucgag      840

aucaagcccc acgacgacug caccgucgag cagaucuacg agauccugaa gaucuaccag      900

cucauggacc acagcaacau ggacugcuuc aucugcugca uccuguccca cggggacaag      960

ggcaucaucu acgggacgga cggccaggag gcccccaucu acgagcugac cagccaguuc     1020

accggccuca agugcccguc ccuggccggg aagcccaagg uguucuucau ccaggcgugc     1080

cagggcgaca acuaccagaa ggggaucccc guggagaccg acagcgagga gcagcccuac     1140

cuggagaugg accucuccag cccgcagacg cgcuacaucc ccgacgaggc cgacuuccug     1200

cugggcaugg ccaccgucaa caacugcgug uccuaccgga accccgccga gggcaccugg     1260

uacauccaga gccucugcca gucccugcgc gagcgcugcc cccgcgggga cgacauccug     1320

accauccuga cggaggugaa cuacgagguc agcaacaagg acgacaagaa gaacaugggc     1380

aagcagaugc cgcagcccac cuucacccuc cggaagaagc ugguguuccc cuccgacuga     1440


<210>  7116
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7116
auggacuucu cccgcaaccu cuacgacauc ggcgagcagc ucgacuccga ggaccucgcc       60

ucccucaagu uccucucccu cgacuacauc ccccagcgca agcaggagcc caucaaggac      120

gcccucaugc ucuuccagcg ccuccaggag aagcgcaugc ucgaggaguc caaccucucc      180

uuccucaagg agcuccucuu ccgcaucaac cgccucgacc uccucaucac cuaccucaac      240

acccgcaagg aggagaugga gcgcgagcuc cagacccccg gccgcgccca gaucuccgcc      300

uaccgcguca ugcucuacca gaucuccgag gaggucuccc gcuccgagcu ccgcuccuuc      360

aaguuccucc uccaggagga gaucuccaag ugcaagcucg acgacgacau gaaccuccuc      420

gacaucuuca ucgagaugga gaagcgcguc auccucggcg agggcaagcu cgacauccuc      480

aagcgcgucu gcgcccagau caacaagucc cuccucaaga ucaucaacga cuacgaggag      540

uucuccaagg agcgcuccuc cucccucgag ggcucccccg acgaguucuc caacggcgag      600

gagcucugcg gcgucaugac caucuccgac uccccccgcg agcaggacuc cgagucccag      660

acccucgaca aggucuacca gaugaagucc aagccccgcg gcuacugccu caucaucaac      720

aaccacaacu ucgccaaggc ccgcgagaag guccccaagc uccacuccau ccgcgaccgc      780

aacggcaccc accucgacgc cggcgcccuc accaccaccu ucgaggagcu ccacuucgag      840

aucaagcccc acgacgacug caccgucgag cagaucuacg agauccucaa gaucuaccag      900

cucauggacc acuccaacau ggacugcuuc aucugcugca uccucuccca cggcgacaag      960

ggcaucaucu acggcaccga cggccaggag gcccccaucu acgagcucac cucccaguuc     1020

accggccuca agugccccuc ccucgccggc aagcccaagg ucuucuucau ccaggccugc     1080

cagggcgaca acuaccagaa gggcaucccc gucgagaccg acuccgagga gcagcccuac     1140

cucgagaugg accucuccuc cccccagacc cgcuacaucc ccgacgaggc cgacuuccuc     1200

cucggcaugg ccaccgucaa caacugcguc uccuaccgca accccgccga gggcaccugg     1260

uacauccagu cccucugcca gucccuccgc gagcgcugcc cccgcggcga cgacauccuc     1320

accauccuca ccgaggucaa cuacgagguc uccaacaagg acgacaagaa gaacaugggc     1380

aagcagaugc cccagcccac cuucacccuc cgcaagaagc ucgucuuccc cuccgacuga     1440


<210>  7117
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7117
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuugcc       60

ucucugaagu uuuugucauu agacuauauu ccccaaagga aacaggagcc uauaaaggau      120

gcucugaugc uauuccagcg gcuccaggaa aaacgcaugc uggaggaaag uaaucuuagc      180

uuucugaagg agcuccucuu ccgaaucaac cgucuggacc ugcucauuac cuacuuaaau      240

acaagaaaag aggaaaugga gagggaacug caaacuccag ggcgggcaca gaucuccgcc      300

uaucgcguga ugcuuuacca gauuucugag gaggucucga gaucagaauu gaggagcuuu      360

aaguuccugc uacaggagga aaucaguaag ugcaaacucg augacgauau gaaccugcuu      420

gacauauuua ucgagaugga aaagcggguu auucugggag aggguaaauu ggauauccuc      480

aagcgcgugu gugcgcaaau uaauaaaucc cuguuaaaga ucauaaacga cuaugaggag      540

uucucuaagg agcgaagcuc cucacuggaa ggcaguccgg augaguuuag caauggggaa      600

gaguugugcg gaguaaugac gauuucugac ucccccagag agcaggacuc agaaagccag      660

acccuugaua aaguguacca gaugaagagu aaaccuaggg gcuauugucu gaucauuaac      720

aaucacaacu ucgcuaaggc ccgggagaaa gucccaaagu ugcauucuau ccgugaccgc      780

aaugguacac accuagaugc aggggcccug acuaccacau uugaagaacu ccauuucgaa      840

aucaaacccc acgacgauug caccguggag caaauuuacg agauacugaa gaucuaccag      900

cuuauggacc auuccaacau ggauuguuuu auuugcugua uccugagcca cggagacaag      960

ggcauaauuu auggcacuga ugggcaggaa gcuccuaucu acgaguugac aucgcaauuc     1020

accggacuca aaugcccauc ucuggcaggu aagcccaaag uuuucuuuau ccaggccugu     1080

cagggcgaca auuaucagaa ggggauuccu guggaaacgg auuccgagga gcaaccauac     1140

uuagaaaugg accugucaag uccgcagacu agauauaucc ccgacgaggc ugauuuccua     1200

cucggaaugg ccaccgucaa caauugcgug agcuacagga acccugcgga aggcacaugg     1260

uauauucagu cccuguguca gucucuucgg gagcgaugcc cacgcgguga cgauauauug     1320

acuauccuga ccgaaguaaa cuacgagguu agcaauaaag acgauaagaa gaacaugggg     1380

aaacaaaugc cccagccuac auuuacccuc agaaagaaac ugguguuccc aucagacuga     1440


<210>  7118
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7118
auggacuuca gcagaaaccu guacgacauc ggcgagcagc uggacagcga ggaccuggcc       60

agccugaagu uccugagccu ggacuacauc ccccagagaa agcaggagcc caucaaggac      120

gcccugaugc uguuccagag acugcaggag aagagaaugc uggaggagag caaccugagc      180

uuccugaagg agcugcuguu cagaaucaac agacuggacc ugcugaucac cuaccugaac      240

accagaaagg aggagaugga gagagagcug cagacccccg gcagagccca gaucagcgcc      300

uacagaguga ugcuguacca gaucagcgag gaggugagca gaagcgagcu gagaagcuuc      360

aaguuccugc ugcaggagga gaucagcaag ugcaagcugg acgacgacau gaaccugcug      420

gacaucuuca ucgagaugga gaagagagug auccugggcg agggcaagcu ggacauccug      480

aagagagugu gcgcccagau caacaagagc cugcugaaga ucaucaacga cuacgaggag      540

uucagcaagg agagaagcag cagccuggag ggcagccccg acgaguucag caacggcgag      600

gagcugugcg gcgugaugac caucagcgac agccccagag agcaggacag cgagagccag      660

acccuggaca agguguacca gaugaagagc aagcccagag gcuacugccu gaucaucaac      720

aaccacaacu ucgccaaggc cagagagaag gugcccaagc ugcacagcau cagagacaga      780

aacggcaccc accuggacgc cggcgcccug accaccaccu ucgaggagcu gcacuucgag      840

aucaagcccc acgacgacug caccguggag cagaucuacg agauccugaa gaucuaccag      900

cugauggacc acagcaacau ggacugcuuc aucugcugca uccugagcca cggcgacaag      960

ggcaucaucu acggcaccga cggccaggag gcccccaucu acgagcugac cagccaguuc     1020

accggccuga agugccccag ccuggccggc aagcccaagg uguucuucau ccaggccugc     1080

cagggcgaca acuaccagaa gggcaucccc guggagaccg acagcgagga gcagcccuac     1140

cuggagaugg accugagcag cccccagacc agauacaucc ccgacgaggc cgacuuccug     1200

cugggcaugg ccaccgugaa caacugcgug agcuacagaa accccgccga gggcaccugg     1260

uacauccaga gccugugcca gagccugaga gagagaugcc ccagaggcga cgacauccug     1320

accauccuga ccgaggugaa cuacgaggug agcaacaagg acgacaagaa gaacaugggc     1380

aagcagaugc cccagcccac cuucacccug agaaagaagc ugguguuccc cagcgacuga     1440


<210>  7119
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7119
auggacuuca gcagaaaccu guacgauauc ggcgagcagc ucgacuccga agaucuggcc       60

ucucuuaagu uucugagccu cgacuauauu ccccaacgga aacaggagcc uaucaaggau      120

gcucugaugc uuuuccagcg ccugcaggag aaaagaaugc ucgaggaauc caaucugucu      180

uuucugaagg agcuccuguu ccggauuaac cgccuugacc ugcucaucac cuaccugaau      240

acaagaaaag aggaaaugga gcgggaacuu caaacgccgg ggcgcgccca gauuagcgcg      300

uauagaguga ugcuguacca gaucuccgag gaggucucuc ggagcgaacu ccgcuccuuu      360

aaguuccugc ugcaggagga aaucagcaag ugcaaacucg augacgauau gaaccugcuu      420

gacauuuuua ucgagaugga aaagagaguu auucugggag agggcaaacu cgauauccug      480

aagcgggugu gugcucaaau uaauaaaucu cuucugaaga ucauuaacga cuaugaggag      540

uucuccaagg agcgcagcag cucccucgaa gggagccccg augaguuuuc uaauggagaa      600

gaacugugcg gcgugaugac caucuccgac agcccuagag agcaggacuc cgaaucucag      660

acacuggaua aagucuacca gaugaagucu aaaccccggg gguauugucu caucauuaac      720

aaucacaacu ucgccaaggc ccgcgagaaa gugccuaagc ugcauuccau cagagaccgg      780

aauggaaccc accuugaugc uggcgcccug acaaccacau uugaagaacu ccauuucgaa      840

auuaaacccc acgacgauug caccguugag caaaucuacg agauucugaa gaucuaccag      900

cuuauggacc auagcaacau ggauuguuuu aucugcugua uucugucuca cggcgacaag      960

gggaucauuu auggaacgga uggccaggaa gcuccuaucu acgagcucac cucccaauuc     1020

acagggcuga aaugcccgag ccuggccgga aagcccaaag uguucuuuau ucaggcgugu     1080

cagggcgaca auuaucagaa ggggaucccu gucgaaaccg auucugagga gcaacccuac     1140

cucgaaaugg accugagcuc cccucagaca agauauaucc ccgacgaggc cgauuuccuu     1200

cugggaaugg cuaccgugaa caauugcguu ucuuaccgca acccggccga aggcacgugg     1260

uauauucaga gccucuguca gucccugcgg gagagaugcc cucgcggcga cgauauccug     1320

acaauucuua ccgaagugaa cuacgagguc agcaauaaag acgauaagaa gaacaugggg     1380

aaacaaaugc cccagccuac auuuacccuc cggaagaaac ugguguuccc cucugacuga     1440


<210>  7120
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_8__Homo_sapiens__CAA66853

<400>  7120
auggacuucu caagaaauuu auacgacaua ggugaacaac uagauucaga agacuuagca       60

ucucuaaagu uucuuucacu agacuacaua ccacaaagaa aacaagaacc aauaaaagau      120

gcccuaaugc uauuccaaag auuacaagaa aaacgaaugc uagaagaauc aaauuuaucu      180

uuucucaaag aauuacucuu uagaauaaac agacuagacc uacuaauaac auaccugaac      240

acacgcaaag aagaaaugga acgagaacua caaaccccag gaagagcaca aauaucagca      300

uauagaguaa ugcuauacca aaucuccgaa gaaguaucca gaucagaacu aagaucauuu      360

aaauuccucc uacaagaaga aauuucaaaa uguaaauuag acgacgacau gaaucuacua      420

gacaucuuca uagaaaugga aaaaagagua auacuaggag aaggaaaauu agauauacua      480

aaacgaguau gcgcacaaau aaauaaauca uuauuaaaaa ucauaaacga cuaugaagaa      540

uuuucaaaag aaagaaguuc aucauuagaa ggaucacccg acgaauucuc caauggagaa      600

gaauuaugcg gaguaaugac aaucucagac aguccaagag aacaagacuc agaaucacaa      660

acccucgaca aaguauacca aaugaaauca aaaccaagag gauacugucu aauaauaaac      720

aaccacaacu ucgccaaagc aagagaaaaa guacccaaau uacacuccau cagagacaga      780

aacgguacuc aucuagaugc aggcgcucuu acaacuacau ucgaagaacu acacuucgaa      840

auaaaaccuc acgacgacug cacaguagaa caaauauaug aaauacuaaa aaucuaucaa      900

cuaauggauc auucaaacau ggacugcuuc auuugcugca uacuaucuca cggagacaaa      960

ggaauaaucu acggaacaga cggacaagaa gcaccaauau augaauuaac aagccaauuu     1020

acaggacuaa aauguccauc acucgcagga aaaccuaaag uauuuuucau acaagcaugc     1080

caaggcgaua auuaccaaaa aggaauaccc guagaaacag acuccgaaga acaaccauac     1140

cucgaaaugg aucuaucauc accacaaacu cgauauauac cagacgaagc agacuuuuua     1200

uuaggcaugg caacaguaaa uaauugcgua ucauauagaa acccagccga aggcacuugg     1260

uacauacaau cccuauguca aucauuaaga gaacgaugcc cccgaggaga cgacauacuc     1320

acaauauuaa cagaaguaaa cuaugaagua uccaauaaag acgauaaaaa aaacaugggc     1380

aaacaaaugc cucaaccuac auuuacacuc agaaaaaaac uaguauuucc aagcgacuaa     1440


<210>  7121
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__A0A024R8F1

<400>  7121

Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Thr Leu Thr Ser Val Ile Asp Pro Ser Arg Ile Thr Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Thr Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Thr Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Thr Gln Leu Leu Met Thr Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Thr Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Thr Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Thr Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ala Ile Ala Thr Arg Glu Glu Leu His 
        355                 360                 365             


Ala Gln His Ala Arg Gly Leu Gln Glu Lys Asp Ala Leu Arg Lys Gln 
    370                 375                 380                 


Val Arg Glu Leu Gly Glu Lys Ala Asp Glu Leu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Gln Cys Glu Ala Gln Leu Leu Ala Val Glu Gly Arg Leu Arg Arg Gln 
                405                 410                 415     


Gln Leu Glu Thr Leu Val Leu Ser Ser Asp Leu Glu Asp Gly Ser Pro 
            420                 425                 430         


Arg Arg Ser Gln Glu Leu Ser Leu Pro Gln Asp Leu Glu Asp Thr Gln 
        435                 440                 445             


Leu Ser Asp Lys Gly Cys Leu Ala Gly Gly Gly Ser Pro Lys Gln Pro 
    450                 455                 460                 


Phe Ala Ala Leu His Gln Glu Gln Val Leu Arg Asn Pro His Asp Ala 
465                 470                 475                 480 


Gly Leu Ser Ser Gly Glu Pro Pro Glu Lys Glu Arg Arg Arg Leu Lys 
                485                 490                 495     


Glu Ser Phe Glu Asn Tyr Arg Arg Lys Arg Ala Leu Arg Lys Met Gln 
            500                 505                 510         


Lys Gly Trp Arg Gln Gly Glu Glu Asp Arg Glu Asn Thr Thr Gly Ser 
        515                 520                 525             


Asp Asn Thr Asp Thr Glu Gly Ser 
    530                 535     


<210>  7122
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__EAW88222

<400>  7122
augucggacu acgagaacga ugacgagugc uggagcgucc uggagggcuu ccgggugacg       60

cucaccucgg ucaucgaccc cucacgcauc acaccuuacc ugcggcagug caagguccug      120

aaccccgaug augaggagca ggugcucagc gaccccaacc uggucauccg caaacggaaa      180

gugggugugc uccuggacau ccugcagcgg accggccaca agggcuacgu ggccuuccuc      240

gagagccugg agcucuacua cccgcagcug uacaagaagg ucacaggcaa ggagccggcc      300

cgcgucuucu ccaugaucau cgacgcgucc ggggagucag gccugacuca gcugcugaug      360

acugagguca ugaagcugca gaagaaggug caggaccuga ccgcgcugcu gagcuccaaa      420

gaugacuuca ucaaggagcu gcgggugaag gacagccugc ugcgcaagca ccaggagcgu      480

gugcagaggc ucaaggagga gugcgaggcc ggcagccgcg agcucaagcg cugcaaggag      540

gagaacuacg accuggccau gcgccuggcg caccagagug aggagaaggg cgccgcgcuc      600

augcggaacc gugaccugca gcuggagauu gaccagcuca agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acgcugaagc ucaggcacgc cauggagcag      720

cggcccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu ccaggcccgg      780

gugcaggagc uggaggccuc cguccaggag gggaagcugg acaggagcag ccccuacauc      840

cagguacugg aggaggacug gcggcaggcg cugcgggacc accaggagca ggccaacacc      900

aucuucuccc ugcgcaagga ccuccgccag ggcgaggccc gacgccuccg gugcauggag      960

gagaaggaga uguucgagcu gcagugccug gcacuacgua aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu gcugcagaug gaggaggucg ccauugagcg ggaccaggcc     1080

auagccacgc gggaggagcu gcacgcacag cacgcccggg gccugcagga gaaggacgcg     1140

cugcgcaagc aggugcggga gcugggcgag aaggcggaug agcugcagcu gcagguguuc     1200

cagugugagg cgcagcuacu ggccguggag ggcaggcuca ggcggcagca gcuggagacg     1260

cucguccuga gcuccgaccu ggaagauggc ucacccagga ggucccagga gcucucacuc     1320

ccccaggacc uggaggacac ccagcucuca gacaaaggcu gccuugccgg cggggggagc     1380

ccgaaacagc ccuuugcagc ucugcaccag gagcagguuu ugcggaaccc ccaugacgca     1440

ggccugagca gcggggagcc gcccgagaag gagcggcggc gccucaaaga gaguuuugag     1500

aacuaccgca ggaagcgcgc ccucaggaag augcagaaag gauggcggca gggggaggag     1560

gaccgggaga acaccacggg cagcgacaac accgacacug agggcuccua g              1611


<210>  7123
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7123
augagcgacu acgagaacga cgacgagugc ugguccgugc uggagggcuu ccgcgugacc       60

cucaccagcg ugaucgaccc cucccggauc acgccguacc ugcgccagug caaggugcug      120

aaccccgacg acgaggagca gguccucagc gaccccaacc uggugauccg gaagcgcaag      180

gugggggucc ugcucgacau ccugcagcgg accggccaca agggguacgu ggccuuccug      240

gagucccucg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagccggcc      300

cgcgucuuca gcaugaucau cgacgcgucc ggggagagcg gccucaccca gcugcugaug      360

acggagguga ugaagcucca gaagaaggug caggaccuga ccgcccugcu cuccagcaag      420

gacgacuuca ucaaggagcu gcgggucaag gacucccugc uccgcaagca ccaggagcgg      480

gugcagcgcc ugaaggagga gugcgaggcc ggcagccggg agcugaagcg cugcaaggag      540

gagaacuacg accucgccau gcggcuggcc caccaguccg aggagaaggg ggcggcccug      600

augcgcaacc gggaccucca gcuggagauc gaccagcuga agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acccugaagc ugcggcacgc cauggagcag      720

cgccccuccc aggagcuccu gugggagcug cagcaggaga aggcgcuccu gcaggcccgg      780

guccaggagc uggaggccag cgugcaggag ggcaagcucg accgcuccag ccccuacauc      840

caggugcugg aggaggacug gcggcaggcc cugcgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccugcggcag ggggaggcgc gccggcugcg cugcauggag      960

gagaaggaga uguucgagcu ccagugccug gcccugcgga aggacagcaa gauguacaag     1020

gaccgcaucg aggccauccu ccugcagaug gaggaggucg ccaucgagcg ggaccaggcc     1080

aucgcgacgc gcgaggagcu gcacgcccag cacgcccggg gccugcagga gaaggacgcc     1140

cuccgcaagc agguccggga gcugggggag aaggccgacg agcugcagcu ccagguguuc     1200

cagugcgagg cgcagcugcu ggccguggag ggccgccucc ggcgccagca gcuggagacc     1260

cuggugcuca gcuccgaccu ggaggacggc agcccccggc gcucccagga gcugagccuc     1320

ccgcaggacc uggaggacac ccagcugucc gacaaggggu gccucgccgg cgggggcagc     1380

cccaagcagc ccuucgccgc ccugcaccag gagcaggucc ugcggaaccc ccacgacgcg     1440

ggccucucca gcggggagcc gcccgagaag gagcgccggc gccugaagga guccuucgag     1500

aacuaccgcc ggaagcgcgc ccugcggaag augcagaagg gcuggcgcca gggggaggag     1560

gaccgggaga acaccacggg cagcgacaac accgacaccg agggguccug a              1611


<210>  7124
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7124
auguccgacu acgagaacga cgacgagugc ugguccgucc ucgagggcuu ccgcgucacc       60

cucaccuccg ucaucgaccc cucccgcauc acccccuacc uccgccagug caagguccuc      120

aaccccgacg acgaggagca gguccucucc gaccccaacc ucgucauccg caagcgcaag      180

gucggcgucc uccucgacau ccuccagcgc accggccaca agggcuacgu cgccuuccuc      240

gagucccucg agcucuacua cccccagcuc uacaagaagg ucaccggcaa ggagcccgcc      300

cgcgucuucu ccaugaucau cgacgccucc ggcgaguccg gccucaccca gcuccucaug      360

accgagguca ugaagcucca gaagaagguc caggaccuca ccgcccuccu cuccuccaag      420

gacgacuuca ucaaggagcu ccgcgucaag gacucccucc uccgcaagca ccaggagcgc      480

guccagcgcc ucaaggagga gugcgaggcc ggcucccgcg agcucaagcg cugcaaggag      540

gagaacuacg accucgccau gcgccucgcc caccaguccg aggagaaggg cgccgcccuc      600

augcgcaacc gcgaccucca gcucgagauc gaccagcuca agcacucccu caugaaggcc      660

gaggacgacu gcaaggucga gcgcaagcac acccucaagc uccgccacgc cauggagcag      720

cgccccuccc aggagcuccu cugggagcuc cagcaggaga aggcccuccu ccaggcccgc      780

guccaggagc ucgaggccuc cguccaggag ggcaagcucg accgcuccuc ccccuacauc      840

cagguccucg aggaggacug gcgccaggcc cuccgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccuccgccag ggcgaggccc gccgccuccg cugcauggag      960

gagaaggaga uguucgagcu ccagugccuc gcccuccgca aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu ccuccagaug gaggaggucg ccaucgagcg cgaccaggcc     1080

aucgccaccc gcgaggagcu ccacgcccag cacgcccgcg gccuccagga gaaggacgcc     1140

cuccgcaagc agguccgcga gcucggcgag aaggccgacg agcuccagcu ccaggucuuc     1200

cagugcgagg cccagcuccu cgccgucgag ggccgccucc gccgccagca gcucgagacc     1260

cucguccucu ccuccgaccu cgaggacggc uccccccgcc gcucccagga gcucucccuc     1320

ccccaggacc ucgaggacac ccagcucucc gacaagggcu gccucgccgg cggcggcucc     1380

cccaagcagc ccuucgccgc ccuccaccag gagcaggucc uccgcaaccc ccacgacgcc     1440

ggccucuccu ccggcgagcc ccccgagaag gagcgccgcc gccucaagga guccuucgag     1500

aacuaccgcc gcaagcgcgc ccuccgcaag augcagaagg gcuggcgcca gggcgaggag     1560

gaccgcgaga acaccaccgg cuccgacaac accgacaccg agggcuccug a              1611


<210>  7125
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7125
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cucaaggauu acuccuuauc uucggcagug uaaggugcug      120

aauccagacg augaggagca aguauugagu gacccgaacu uagugauacg caaacgaaag      180

gucggggugc ugcuagauau ccuccagcgu acgggacaca aagguuacgu ugccuuucug      240

gaaagccuug agcuguauua cccccaguug uauaagaaag ugaccggcaa ggagccugcu      300

agagucuucu ccaugauuau cgacgcaucu ggggaaucgg gacucacaca gcugcugaug      360

acugagguga ugaagcucca aaagaaggua caggauuuaa ccgcccugcu uucaagcaaa      420

gacgauuuua uuaaggaauu gaggguuaaa gacagucugc uacggaagca ucaggagcgc      480

gugcagagac ucaaggagga augcgaggcg ggcuccaggg aacugaaacg guguaaggag      540

gaaaauuacg aucuugcuau gcgccuggcc caccaaucug aggagaaagg ugcagccuug      600

augcgaaaca gagaccucca gcuggaaauc gaccaguuaa agcauagccu gaugaaagcu      660

gaggaugacu gcaaggucga aaggaaacac acacucaaac uucggcaugc aauggagcag      720

cguccauccc aagaacuguu gugggagcua cagcaggaga aggcccugcu ccaagcucgc      780

gugcaggaac uggaggccuc agugcaggaa gggaaacuug auagaaguag ccccuauaua      840

cagguccugg aggaagacug gaggcaagcg uugcgggauc accaggagca ggcaaauacc      900

aucuucucuc uccgaaagga ccugcgccag ggagaggcca gaagguuacg guguauggaa      960

gagaaagaaa uguuugagcu gcaaugccua gcucuccgca aggauuccaa aauguacaag     1020

gacagaauug aggccauccu gcuucagaug gaagagguug caauugaaag ggaucaggcu     1080

aucgccacuc gugaggaauu gcacgcgcag caugcccggg gccugcaaga gaaggacgca     1140

cuccgaaaac aggugagaga gcugggcgaa aaggcugaug agcuucagcu gcagguauuc     1200

caaugugaag cccaguugcu cgcuguggag gggaggcugc gccggcagca auuagaaaca     1260

cugguccuau caagcgaccu cgaggacgga aguccuagaa ggucucagga gcugucccuu     1320

ccacaggauu uggaagacac ccagcugagc gauaaagguu gccucgccgg cgggggaucg     1380

cccaagcaac cuuuugcagc ccugcaccag gaacaggugu uacgcaaccc acaugacgcu     1440

ggccugucuu ccggugaacc gcccgagaaa gaacgacggc gucuuaagga gucauucgag     1500

aauuacagaa ggaagcgcgc guugcggaaa augcagaagg gguggagaca aggagaagag     1560

gauagggaaa acacgacugg cagugacaau accgauacag agggcagcug a              1611


<210>  7126
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7126
augagcgacu acgagaacga cgacgagugc uggagcgugc uggagggcuu cagagugacc       60

cugaccagcg ugaucgaccc cagcagaauc acccccuacc ugagacagug caaggugcug      120

aaccccgacg acgaggagca ggugcugagc gaccccaacc uggugaucag aaagagaaag      180

gugggcgugc ugcuggacau ccugcagaga accggccaca agggcuacgu ggccuuccug      240

gagagccugg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagcccgcc      300

agaguguuca gcaugaucau cgacgccagc ggcgagagcg gccugaccca gcugcugaug      360

accgagguga ugaagcugca gaagaaggug caggaccuga ccgcccugcu gagcagcaag      420

gacgacuuca ucaaggagcu gagagugaag gacagccugc ugagaaagca ccaggagaga      480

gugcagagac ugaaggagga gugcgaggcc ggcagcagag agcugaagag augcaaggag      540

gagaacuacg accuggccau gagacuggcc caccagagcg aggagaaggg cgccgcccug      600

augagaaaca gagaccugca gcuggagauc gaccagcuga agcacagccu gaugaaggcc      660

gaggacgacu gcaaggugga gagaaagcac acccugaagc ugagacacgc cauggagcag      720

agacccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu gcaggccaga      780

gugcaggagc uggaggccag cgugcaggag ggcaagcugg acagaagcag ccccuacauc      840

caggugcugg aggaggacug gagacaggcc cugagagacc accaggagca ggccaacacc      900

aucuucagcc ugagaaagga ccugagacag ggcgaggcca gaagacugag augcauggag      960

gagaaggaga uguucgagcu gcagugccug gcccugagaa aggacagcaa gauguacaag     1020

gacagaaucg aggccauccu gcugcagaug gaggaggugg ccaucgagag agaccaggcc     1080

aucgccacca gagaggagcu gcacgcccag cacgccagag gccugcagga gaaggacgcc     1140

cugagaaagc aggugagaga gcugggcgag aaggccgacg agcugcagcu gcagguguuc     1200

cagugcgagg cccagcugcu ggccguggag ggcagacuga gaagacagca gcuggagacc     1260

cuggugcuga gcagcgaccu ggaggacggc agccccagaa gaagccagga gcugagccug     1320

ccccaggacc uggaggacac ccagcugagc gacaagggcu gccuggccgg cggcggcagc     1380

cccaagcagc ccuucgccgc ccugcaccag gagcaggugc ugagaaaccc ccacgacgcc     1440

ggccugagca gcggcgagcc ccccgagaag gagagaagaa gacugaagga gagcuucgag     1500

aacuacagaa gaaagagagc ccugagaaag augcagaagg gcuggagaca gggcgaggag     1560

gacagagaga acaccaccgg cagcgacaac accgacaccg agggcagcug a              1611


<210>  7127
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7127
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cagccggauu acgccuuauc ugcgccagug uaaggugcuu      120

aauccggacg augaggaaca agugcugucc gaccccaacc ucgucaucag aaaacggaag      180

guggggguuc ugcuugauau ucugcagcgc accggacaca aaggcuacgu ggccuuucuc      240

gaaucucugg agcuguauua cccucagcuc uauaagaaag ucacagggaa ggagcccgcu      300

agaguguuca gcaugaucau ugacgccucc ggagaaucug gccugaccca gcuucugaug      360

acagagguua ugaagcucca gaaaaaggug caagaucuga ccgcgcuucu gagcuccaaa      420

gacgauuuua ucaaggaacu ccgggucaaa gacagccugc ugcgcaagca ucaggagaga      480

gugcagcggc ucaaggagga augcgaggcu gggucucgcg aacugaaaag auguaaggag      540

gaaaauuacg aucuugccau gcggcuggcc caccaauccg aggagaaagg agcugcccuc      600

augcgcaaca gagaccugca gcuugaaauc gaccagcuga agcauagccu caugaaagcu      660

gaggaugacu gcaaggugga acggaaacac acacugaagc ugcgccaugc cauggagcag      720

agaccuucuc aagaacuccu gugggagcuu cagcaggaga aggcgcugcu ccaagcccgg      780

guccaggaac uggaggcuuc cguucaggaa ggcaaacuug auagaagcuc ucccuauauu      840

caggugcugg aggaagacug gcgccaagcc cuccgggauc accaggagca ggcuaauacc      900

aucuucuccc ugagaaagga ccugcgccag ggcgaggccc ggagacuccg cuguauggaa      960

gagaaagaaa uguuugagcu gcaaugccuu gcgcugcgga aggauagcaa aauguacaag     1020

gacagaauug aggccauccu ccugcagaug gaagaggugg cuauugaacg cgaucaggcc     1080

aucgcuacgc gggaggaacu gcacgcccag caugccagag ggcuucaaga gaaggacgcu     1140

cuccgcaaac agguccggga gcugggagaa aaggcggaug agcugcagcu ccagguguuc     1200

caaugugaag cccagcugcu ugcuguugag ggcagacugc ggcgccagca acucgaaacc     1260

cuggugcugu ccucugaccu ugaggacggg agcccuagac ggucccagga gcucagccug     1320

ccgcaggauc uggaagacac acagcucucu gauaaaggau gccuggccgg cgggggaucc     1380

cccaagcaac cuuuugccgc ccuucaccag gagcaggucc ugagaaaccc ccaugacgcu     1440

ggccucagcu cuggcgaacc ucccgagaaa gaacgccgga gacugaagga gagcuucgag     1500

aauuaccgca gaaagcgggc gcugcgcaaa augcagaagg gguggagaca aggagaagag     1560

gaucgggaaa acaccacagg cuccgacaau accgauacgg aggggucuug a              1611


<210>  7128
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_9__Homo_sapiens__EAW88222

<400>  7128
augucagauu acgaaaauga ugaugaaugu uggucaguuu uagaaggauu uagagugaca       60

cuaaccucag uaauagaccc aaguaggaua acaccauauc uaagacaaug uaaagugcua      120

aauccagaug acgaagaaca aguauuaagc gauccaaauc uaguaauaag aaaaagaaaa      180

guaggaguuc ucuuagacau acuccaacga acaggacaca agggauacgu agcauuucua      240

gaaagccugg aauuauauua uccacaacuc uacaaaaaag ucacaggaaa agaaccagca      300

agagucuuua gcaugauaau agaugcgagu ggagaaucug gacuaacaca auuauuaaug      360

acugaaguua ugaaacuuca aaaaaaagua caagacuuaa cagcuuuauu aagcucaaaa      420

gacgacuuua uuaaagaauu acgaguaaaa gauagcuuac ugagaaaaca ccaagaacga      480

guacaaagac uaaaagaaga augcgaagca gggagcagag aacuaaaaag auguaaagaa      540

gaaaauuaug acuuagccau gagauuagcu caucaaucgg aagaaaaagg agcugcauua      600

augcgaaauc gagaucucca acuugaaaua gaucaguuga aacauucauu aaugaaagca      660

gaagacgauu gcaaaguaga acgaaagcac acacuaaaac uaagacacgc aauggaacaa      720

agacccaguc aagaauuacu gugggaauua caacaagaaa aagcacuauu acaagcaagg      780

guacaagaac uagaagccuc aguacaagaa gggaaacuag accguagcag cccuuacaua      840

caaguacuag aagaagacug gcgacaagca cuaagagauc accaggaaca ggccaauaca      900

auauuuucac uaaggaaaga ucuaaggcaa ggugaagcaa gacgauuaag auguauggaa      960

gaaaaagaaa uguuugaauu gcaauguuua gcacuaagaa aagauucaaa aauguauaaa     1020

gauagaauug aagcaauacu uuuacaaaug gaagaaguag ccauagaaag agaucaggca     1080

aucgcaacaa gagaagaauu gcacgcacaa caugcaagag gacuacaaga aaaagaugca     1140

uuacgcaaac aagugagaga acuaggagaa aaagcagaug aauuacaauu acaaguauuc     1200

caaugcgaag cacagcuauu agcaguagaa ggaagauuaa gaagacaaca auuagaaacc     1260

uuagucuuau caucagacuu agaagaugga ucacccagaa gaucacaaga auuaucguua     1320

ccacaagauc uugaagacac acaauuaagu gauaaaggau gcuuagcagg cgggggaagc     1380

ccaaaacaac ccuuugcagc auuacaucaa gaacaagugc uccgcaaucc gcaugaugcc     1440

ggacucagua gcggugaacc uccagagaaa gaaagaagaa gauugaaaga aagcuuugaa     1500

aauuauaggc gcaaaagagc acucagaaaa augcaaaaag gauggagaca aggagaagaa     1560

gaucgagaaa acacaaccgg uagcgauaau acagacacag aaggaaguua a              1611


<210>  7129
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__A0A024R8I4

<400>  7129

Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Thr Leu Thr Ser Val Ile Asp Pro Ser Arg Ile Thr Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Thr Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Thr Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Thr Gln Leu Leu Met Thr Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Thr Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Thr Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Thr Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ser Thr Gln Met Glu Gly Leu 
        355                 360                 365     


<210>  7130
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__EAW88219

<400>  7130
augucggacu acgagaacga ugacgagugc uggagcgucc uggagggcuu ccgggugacg       60

cucaccucgg ucaucgaccc cucacgcauc acaccuuacc ugcggcagug caagguccug      120

aaccccgaug augaggagca ggugcucagc gaccccaacc uggucauccg caaacggaaa      180

gugggugugc uccuggacau ccugcagcgg accggccaca agggcuacgu ggccuuccuc      240

gagagccugg agcucuacua cccgcagcug uacaagaagg ucacaggcaa ggagccggcc      300

cgcgucuucu ccaugaucau cgacgcgucc ggggagucag gccugacuca gcugcugaug      360

acugagguca ugaagcugca gaagaaggug caggaccuga ccgcgcugcu gagcuccaaa      420

gaugacuuca ucaaggagcu gcgggugaag gacagccugc ugcgcaagca ccaggagcgu      480

gugcagaggc ucaaggagga gugcgaggcc ggcagccgcg agcucaagcg cugcaaggag      540

gagaacuacg accuggccau gcgccuggcg caccagagug aggagaaggg cgccgcgcuc      600

augcggaacc gugaccugca gcuggagauu gaccagcuca agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acgcugaagc ucaggcacgc cauggagcag      720

cggcccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu ccaggcccgg      780

gugcaggagc uggaggccuc cguccaggag gggaagcugg acaggagcag ccccuacauc      840

cagguacugg aggaggacug gcggcaggcg cugcgggacc accaggagca ggccaacacc      900

aucuucuccc ugcgcaagga ccuccgccag ggcgaggccc gacgccuccg gugcauggag      960

gagaaggaga uguucgagcu gcagugccug gcacuacgua aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu gcugcagaug gaggaggucg ccauugagcg ggaccagagc     1080

acacaaaugg aggggcugug a                                               1101


<210>  7131
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7131
augagcgacu acgagaacga cgacgagugc ugguccgugc uggagggcuu ccgcgucacc       60

cucaccagcg ugaucgaccc cucccggauc acgccguacc ugcgccagug caaggugcug      120

aaccccgacg acgaggagca gguccucagc gaccccaacc uggugauccg gaagcgcaag      180

gugggggucc ugcucgacau ccugcagcgg accggccaca agggguacgu ggccuuccug      240

gagucccucg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagccggcc      300

cgcgucuuca gcaugaucau cgacgcgucc ggggagagcg gccucaccca gcugcugaug      360

acggagguga ugaagcucca gaagaaggug caggaccuga ccgcccugcu cuccagcaag      420

gacgacuuca ucaaggagcu gcgggucaag gacucccugc uccgcaagca ccaggagcgg      480

gugcagcgcc ugaaggagga gugcgaggcc ggcagccggg agcugaagcg cugcaaggag      540

gagaacuacg accucgccau gcggcuggcc caccaguccg aggagaaggg ggcggcccug      600

augcgcaacc gggaccucca gcuggagauc gaccagcuga agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acccugaagc ugcggcacgc cauggagcag      720

cgccccuccc aggagcuccu gugggagcug cagcaggaga aggcgcuccu gcaggcccgg      780

guccaggagc uggaggccag cgugcaggag ggcaagcucg accgcuccag ccccuacauc      840

caggugcugg aggaggacug gcggcaggcc cugcgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccugcggcag ggggaggcgc gccggcugcg cugcauggag      960

gagaaggaga uguucgagcu ccagugccug gcccugcgga aggacagcaa gauguacaag     1020

gaccgcaucg aggccauccu ccugcagaug gaggaggucg ccaucgagcg ggaccagagc     1080

acgcagaugg agggccugug a                                               1101


<210>  7132
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7132
auguccgacu acgagaacga cgacgagugc ugguccgucc ucgagggcuu ccgcgucacc       60

cucaccuccg ucaucgaccc cucccgcauc acccccuacc uccgccagug caagguccuc      120

aaccccgacg acgaggagca gguccucucc gaccccaacc ucgucauccg caagcgcaag      180

gucggcgucc uccucgacau ccuccagcgc accggccaca agggcuacgu cgccuuccuc      240

gagucccucg agcucuacua cccccagcuc uacaagaagg ucaccggcaa ggagcccgcc      300

cgcgucuucu ccaugaucau cgacgccucc ggcgaguccg gccucaccca gcuccucaug      360

accgagguca ugaagcucca gaagaagguc caggaccuca ccgcccuccu cuccuccaag      420

gacgacuuca ucaaggagcu ccgcgucaag gacucccucc uccgcaagca ccaggagcgc      480

guccagcgcc ucaaggagga gugcgaggcc ggcucccgcg agcucaagcg cugcaaggag      540

gagaacuacg accucgccau gcgccucgcc caccaguccg aggagaaggg cgccgcccuc      600

augcgcaacc gcgaccucca gcucgagauc gaccagcuca agcacucccu caugaaggcc      660

gaggacgacu gcaaggucga gcgcaagcac acccucaagc uccgccacgc cauggagcag      720

cgccccuccc aggagcuccu cugggagcuc cagcaggaga aggcccuccu ccaggcccgc      780

guccaggagc ucgaggccuc cguccaggag ggcaagcucg accgcuccuc ccccuacauc      840

cagguccucg aggaggacug gcgccaggcc cuccgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccuccgccag ggcgaggccc gccgccuccg cugcauggag      960

gagaaggaga uguucgagcu ccagugccuc gcccuccgca aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu ccuccagaug gaggaggucg ccaucgagcg cgaccagucc     1080

acccagaugg agggccucug a                                               1101


<210>  7133
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7133
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cucaaggauu acuccuuauc uucggcagug uaaggugcug      120

aauccagacg augaggaaca aguauugagu gacccgaacu uagugauacg caaacgaaag      180

gucggggugc ugcuagauau ccuccagcgu acgggacaca aagguuacgu ugccuuucug      240

gaaagccuug agcuguauua cccccaguug uauaagaaag ugaccggcaa ggagccugcu      300

agagucuucu ccaugauuau cgacgcaucu ggggaaucgg gacucacaca gcugcugaug      360

acugagguga ugaagcucca aaagaaggua caggauuuaa ccgcccugcu uucaagcaaa      420

gacgauuuua uuaaggaauu gaggguuaaa gacagucugc uacggaagca ucaggagcgc      480

gugcagagac ucaaggagga augcgaggcg ggcuccaggg aacugaaacg guguaaggag      540

gaaaauuacg aucuugcuau gcgccuggcc caccaaucug aggagaaagg ugcagccuug      600

augcgaaaca gagaccucca gcuggaaauc gaccaguuaa agcauagccu gaugaaagcu      660

gaggaugacu gcaaggucga aaggaaacac acacucaaac uucggcaugc aauggagcag      720

cguccauccc aagaacuguu gugggagcua cagcaggaga aggcccugcu ccaagcucgc      780

gugcaggaac uggaggccuc agugcaggaa gggaaacuug auagaaguag ccccuauaua      840

cagguccugg aggaagacug gaggcaagcg uugcgggauc accaggagca ggcaaauacc      900

aucuucucuc uccgaaagga ccugcgccag ggagaggcca gaagguuacg guguauggaa      960

gagaaagaaa uguuugagcu gcaaugccua gcucuccgca aggauuccaa aauguacaag     1020

gacagaauug aggccauccu gcuucagaug gaagagguug caauugaaag ggaucaguca     1080

acucagaugg agggcuugug a                                               1101


<210>  7134
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7134
augagcgacu acgagaacga cgacgagugc uggagcgugc uggagggcuu cagagugacc       60

cugaccagcg ugaucgaccc cagcagaauc acccccuacc ugagacagug caaggugcug      120

aaccccgacg acgaggagca ggugcugagc gaccccaacc uggugaucag aaagagaaag      180

gugggcgugc ugcuggacau ccugcagaga accggccaca agggcuacgu ggccuuccug      240

gagagccugg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagcccgcc      300

agaguguuca gcaugaucau cgacgccagc ggcgagagcg gccugaccca gcugcugaug      360

accgagguga ugaagcugca gaagaaggug caggaccuga ccgcccugcu gagcagcaag      420

gacgacuuca ucaaggagcu gagagugaag gacagccugc ugagaaagca ccaggagaga      480

gugcagagac ugaaggagga gugcgaggcc ggcagcagag agcugaagag augcaaggag      540

gagaacuacg accuggccau gagacuggcc caccagagcg aggagaaggg cgccgcccug      600

augagaaaca gagaccugca gcuggagauc gaccagcuga agcacagccu gaugaaggcc      660

gaggacgacu gcaaggugga gagaaagcac acccugaagc ugagacacgc cauggagcag      720

agacccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu gcaggccaga      780

gugcaggagc uggaggccag cgugcaggag ggcaagcugg acagaagcag ccccuacauc      840

caggugcugg aggaggacug gagacaggcc cugagagacc accaggagca ggccaacacc      900

aucuucagcc ugagaaagga ccugagacag ggcgaggcca gaagacugag augcauggag      960

gagaaggaga uguucgagcu gcagugccug gcccugagaa aggacagcaa gauguacaag     1020

gacagaaucg aggccauccu gcugcagaug gaggaggugg ccaucgagag agaccagagc     1080

acccagaugg agggccugug a                                               1101


<210>  7135
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7135
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cagccggauu acgccuuauc ugcgccagug uaaggugcuu      120

aauccggacg augaggaaca agugcugucc gaccccaacc ucgucaucag aaaacggaag      180

guggggguuc ugcuugauau ucugcagcgc accggacaca aaggcuacgu ggccuuucuc      240

gaaucucugg agcuguauua cccucagcuc uauaagaaag ucacagggaa ggagcccgcu      300

agaguguuca gcaugaucau ugacgccucc ggagaaucug gccugaccca gcuucugaug      360

acagagguua ugaagcucca gaaaaaggug caagaucuga ccgcgcuucu gagcuccaaa      420

gacgauuuua ucaaggaacu ccgggucaaa gacagccugc ugcgcaagca ucaggagaga      480

gugcagcggc ucaaggagga augcgaggcu gggucucgcg aacugaaaag auguaaggag      540

gaaaauuacg aucuugccau gcggcuggcc caccaauccg aggagaaagg agcugcccuc      600

augcgcaaca gagaccugca gcuugaaauc gaccagcuga agcauagccu caugaaagcu      660

gaggaugacu gcaaggugga acggaaacac acacugaagc ugcgccaugc cauggagcag      720

agaccuucuc aagaacuccu gugggagcuu cagcaggaga aggcgcugcu ccaagcccgg      780

guccaggaac uggaggcuuc cguucaggaa ggcaaacuug auagaagcuc ucccuauauu      840

caggugcugg aggaagacug gcgccaagcc cuccgggauc accaggagca ggcuaauacc      900

aucuucuccc ugagaaagga ccugcgccag ggcgaggccc ggagacuccg cuguauggaa      960

gagaaagaaa uguuugagcu gcaaugccuu gcgcugcgga aggauagcaa aauguacaag     1020

gacagaauug aggccauccu ccugcagaug gaagaggugg cuauugaacg cgaucagucc     1080

acgcagaugg aggggcugug a                                               1101


<210>  7136
<211>  1101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_9__Homo_sapiens__EAW88219

<400>  7136
augagugauu acgaaaauga ugaugagugc uggagcguau uagaaggauu cagaguaaca       60

uuaacaucag uaauagaccc aaguagaaua acaccauacc uaagacaaug caaaguacua      120

aaucccgaug acgaagaaca aguacuauca gauccaaauc uaguaauaag aaaaagaaaa      180

guaggaguac uauuagacau auuacagaga acaggacaua aaggauacgu agcauuccua      240

gaaaguuuag aauuauacua uccacaacua uauaaaaaag uaacuggaaa agaaccagca      300

agaguauuua guaugauaau agacgcaagu ggggaaagug gauuaacaca acuauugaug      360

acagaaguaa ugaaacuaca gaaaaaagua caagaccuaa cagcgcuacu aagcucaaaa      420

gacgacuuua uaaaggaacu gagaguaaaa gacaguuuac uaagaaaaca ccaagaacga      480

guucaacgac ucaaagaaga augcgaagca ggaagcagag aauugaaaag augcaaagaa      540

gaaaacuaug auuuagcaau gagauuagca caucaaucag aagaaaaagg agccgcacua      600

augcgaaaca gagaucucca acuagagaua gaucaauuaa aacauagucu aaugaaagca      660

gaagacgauu gcaaaguaga aagaaaacac acgcuaaagc uaagacaugc aauggaacaa      720

agaccaucac aagaacuacu augggaacua caacaagaaa aagcacuauu acaagcaaga      780

guacaagaac uagaagcauc aguccaagaa ggaaaauuag acagaagcuc acccuauauc      840

caaguccugg aagaagauug gcgacaggca uuaagagauc accaagaaca agcaaacaca      900

auauucucau uaagaaaaga uuuaagacaa ggugaggcaa gaagacuaag augcauggag      960

gaaaaggaaa uguucgaauu acaaugucua gcacuaagaa aagauagcaa gauguauaaa     1020

gauagaauag aagcuauauu acuacaaaug gaagaaguag caauagaaag agaucaauca     1080

acacaaaugg aaggacuaua a                                               1101


<210>  7137
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__P55211

<400>  7137

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                405                 410                 415     






<210>  7138
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__AAH02452

<400>  7138
auggacgaag cggaucggcg gcuccugcgg cggugccggc ugcggcuggu ggaagagcug       60

cagguggacc agcucuggga cgcccugcug agccgcgagc uguucaggcc ccauaugauc      120

gaggacaucc agcgggcagg cucuggaucu cggcgggauc aggccaggca gcugaucaua      180

gaucuggaga cucgagggag ucaggcucuu ccuuuguuca ucuccugcuu agaggacaca      240

ggccaggaca ugcuggcuuc guuucugcga acuaacaggc aagcagcaaa guugucgaag      300

ccaacccuag aaaaccuuac cccaguggug cucagaccag agauucgcaa accagagguu      360

cucagaccgg aaacacccag accaguggac auugguucug gaggauuugg ugaugucggu      420

gcucuugaga guuugagggg aaaugcagau uuggcuuaca uccugagcau ggagcccugu      480

ggccacugcc ucauuaucaa caaugugaac uucugccgug aguccgggcu ccgcacccgc      540

acuggcucca acaucgacug ugagaaguug cggcgucgcu ucuccucgcu gcauuucaug      600

guggagguga agggcgaccu gacugccaag aaaauggugc uggcuuugcu ggagcuggcg      660

cagcaggacc acggugcucu ggacugcugc guggugguca uucucucuca cggcugucag      720

gccagccacc ugcaguuccc aggggcuguc uacggcacag auggaugccc ugugucgguc      780

gagaagauug ugaacaucuu caaugggacc agcugcccca gccugggagg gaagcccaag      840

cucuuuuuca uccaggccug ugguggggag cagaaagacc auggguuuga gguggccucc      900

acuuccccug aagacgaguc cccuggcagu aaccccgagc cagaugccac cccguuccag      960

gaagguuuga ggaccuucga ccagcuggac gccauaucua guuugcccac acccagugac     1020

aucuuugugu ccuacucuac uuucccaggu uuuguuuccu ggagggaccc caagaguggc     1080

uccugguacg uugagacccu ggacgacauc uuugagcagu gggcucacuc ugaagaccug     1140

cagucccucc ugcuuagggu cgcuaaugcu guuucgguga aagggauuua uaaacagaug     1200

ccugguugcu uuaauuuccu ccggaaaaaa cuuuucuuua aaacaucaua a              1251


<210>  7139
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7139
auggacgagg ccgaccgccg gcugcuccgc cggugccgcc ugcggcuggu ggaggagcuc       60

caggucgacc agcuguggga cgcccugcuc agccgcgagc uguuccggcc ccacaugauc      120

gaggacaucc agcgcgcggg cuccgggagc cggcgcgacc aggcccggca gcugaucauc      180

gaccucgaga cccgcggcuc ccaggcccug ccgcuguuca ucagcugccu cgaggacacc      240

gggcaggaca ugcuggccuc cuuccugcgg acgaaccgcc aggccgcgaa gcucagcaag      300

cccacccugg agaaccugac ccccguggug cuccggcccg agauccgcaa gccggagguc      360

cugcggcccg agacgccccg ccccguggac aucggcuccg ggggcuucgg cgacgugggg      420

gcccuggaga gccuccgggg caacgccgac cuggccuaca uccuguccau ggagccgugc      480

gggcacugcc ucaucaucaa caacgucaac uucugccgcg agagcggccu gcggacccgc      540

accgggucca acaucgacug cgagaagcug cgccggcgcu ucagcucccu ccacuucaug      600

guggagguga agggcgaccu gaccgcgaag aagauggucc uggcccuccu ggagcuggcc      660

cagcaggacc acggcgcccu cgacugcugc guggugguca uccugagcca cgggugccag      720

gccucccacc uccaguuccc cggcgcggug uacgggaccg acggcugccc cgugagcguc      780

gagaagaucg ugaacaucuu caacggcacg uccugcccca gccucggggg caagccgaag      840

cuguucuuca uccaggccug cgggggcgag cagaaggacc acggguucga gguggccucc      900

accagccccg aggacgagag ccccggcucc aaccccgagc cggacgccac ccccuuccag      960

gagggccugc ggaccuucga ccagcuggac gccaucagcu cccugcccac gcccagcgac     1020

aucuucgucu ccuacagcac cuucccgggg uucguguccu ggcgcgaccc caagagcggc     1080

uccugguacg uggagacccu ggacgacauc uucgagcagu gggcgcacag cgaggaccuc     1140

cagucccugc ugcuccgggu cgccaacgcc gugagcguga aggggaucua caagcagaug     1200

cccggcugcu ucaacuuccu gcgcaagaag cuguucuuca agaccuccug a              1251


<210>  7140
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7140
auggacgagg ccgaccgccg ccuccuccgc cgcugccgcc uccgccucgu cgaggagcuc       60

caggucgacc agcucuggga cgcccuccuc ucccgcgagc ucuuccgccc ccacaugauc      120

gaggacaucc agcgcgccgg cuccggcucc cgccgcgacc aggcccgcca gcucaucauc      180

gaccucgaga cccgcggcuc ccaggcccuc ccccucuuca ucuccugccu cgaggacacc      240

ggccaggaca ugcucgccuc cuuccuccgc accaaccgcc aggccgccaa gcucuccaag      300

cccacccucg agaaccucac ccccgucguc cuccgccccg agauccgcaa gcccgagguc      360

cuccgccccg agaccccccg ccccgucgac aucggcuccg gcggcuucgg cgacgucggc      420

gcccucgagu cccuccgcgg caacgccgac cucgccuaca uccucuccau ggagcccugc      480

ggccacugcc ucaucaucaa caacgucaac uucugccgcg aguccggccu ccgcacccgc      540

accggcucca acaucgacug cgagaagcuc cgccgccgcu ucuccucccu ccacuucaug      600

gucgagguca agggcgaccu caccgccaag aagauggucc ucgcccuccu cgagcucgcc      660

cagcaggacc acggcgcccu cgacugcugc gucgucguca uccucuccca cggcugccag      720

gccucccacc uccaguuccc cggcgccguc uacggcaccg acggcugccc cgucuccguc      780

gagaagaucg ucaacaucuu caacggcacc uccugccccu cccucggcgg caagcccaag      840

cucuucuuca uccaggccug cggcggcgag cagaaggacc acggcuucga ggucgccucc      900

accucccccg aggacgaguc ccccggcucc aaccccgagc ccgacgccac ccccuuccag      960

gagggccucc gcaccuucga ccagcucgac gccaucuccu cccuccccac ccccuccgac     1020

aucuucgucu ccuacuccac cuuccccggc uucgucuccu ggcgcgaccc caaguccggc     1080

uccugguacg ucgagacccu cgacgacauc uucgagcagu gggcccacuc cgaggaccuc     1140

cagucccucc uccuccgcgu cgccaacgcc gucuccguca agggcaucua caagcagaug     1200

cccggcugcu ucaacuuccu ccgcaagaag cucuucuuca agaccuccug a              1251


<210>  7141
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7141
auggacgagg ccgauagaag gcugcuccgg cgcugccgac uucgucuggu ggaagaguug       60

caggucgacc aauuauggga ugcucugcua agcagagaac ucuucaggcc ccacaugauc      120

gaggacauuc agcgggcagg cuccgggucu cgcagagauc aggccaggca gcugauaauc      180

gaccuugaaa cccggggauc acaagcgcug ccuuuguuua uuaguugucu cgaggauaca      240

ggucaggaca ugcuggcuag cuuccugcgc acuaaccgac aggccgcaaa gcucuccaaa      300

ccaacguuag agaaucugac cccgguugug cuuagacccg aaaucaggaa gccugaggua      360

uugcggccag aaacaccccg uccuguggau auuggcucug ggggauuugg cgacgucggu      420

gcccuggagu cgcuacgcgg gaacgcugau cucgcauaca uccugucaau ggagccaugc      480

ggacauuguc uuauaaucaa uaacgugaau uucugcagag aaagcggccu gaggacucgg      540

accggcagua acauugacug ugagaaauug cgacgcagau uuuccucucu ccacuucaug      600

guugaaguga agggggaucu gacagccaaa aagauggucu uagcucugcu cgagcuugcc      660

cagcaagacc auggagcgcu ggacugcugu gugguaguua ucuugagcca cgguugccag      720

gcaucccauc uacaguuucc cggcgccgug uaugggaccg auggaugucc ugucucagug      780

gaaaagauug ugaauaucuu caacggcaca aguugcccaa gccugggugg gaaaccgaag      840

cucuuuuuca uacaggcuug uggaggcgag caaaaagacc acggcuuuga ggucgccucu      900

acuucccccg aagaugaguc accugggagc aauccagaac ccgacgcaac cccuuuccag      960

gagggacuga ggacguuuga ucagcuugac gcuauuaguu cucugccaac ucccuccgau     1020

aucuucguua gcuacucgac cuucccgggu uuugugucuu ggcgggaccc uaaguccggc     1080

ucaugguaug uagaaacauu ggaugacauu uucgagcaau gggcccacag ugaggaucuc     1140

cagagccugu uacugcgcgu ggcgaacgcc gucuccguga aagggaucua caagcagaug     1200

cccggaugcu uuaauuuccu aagaaagaaa cucuuuuuca agacuucuug a              1251


<210>  7142
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7142
auggacgagg ccgacagaag acugcugaga agaugcagac ugagacuggu ggaggagcug       60

cagguggacc agcuguggga cgcccugcug agcagagagc uguucagacc ccacaugauc      120

gaggacaucc agagagccgg cagcggcagc agaagagacc aggccagaca gcugaucauc      180

gaccuggaga ccagaggcag ccaggcccug ccccuguuca ucagcugccu ggaggacacc      240

ggccaggaca ugcuggccag cuuccugaga accaacagac aggccgccaa gcugagcaag      300

cccacccugg agaaccugac ccccguggug cugagacccg agaucagaaa gcccgaggug      360

cugagacccg agacccccag acccguggac aucggcagcg gcggcuucgg cgacgugggc      420

gcccuggaga gccugagagg caacgccgac cuggccuaca uccugagcau ggagcccugc      480

ggccacugcc ugaucaucaa caacgugaac uucugcagag agagcggccu gagaaccaga      540

accggcagca acaucgacug cgagaagcug agaagaagau ucagcagccu gcacuucaug      600

guggagguga agggcgaccu gaccgccaag aagauggugc uggcccugcu ggagcuggcc      660

cagcaggacc acggcgcccu ggacugcugc guggugguga uccugagcca cggcugccag      720

gccagccacc ugcaguuccc cggcgccgug uacggcaccg acggcugccc cgugagcgug      780

gagaagaucg ugaacaucuu caacggcacc agcugcccca gccugggcgg caagcccaag      840

cuguucuuca uccaggccug cggcggcgag cagaaggacc acggcuucga gguggccagc      900

accagccccg aggacgagag ccccggcagc aaccccgagc ccgacgccac ccccuuccag      960

gagggccuga gaaccuucga ccagcuggac gccaucagca gccugcccac ccccagcgac     1020

aucuucguga gcuacagcac cuuccccggc uucgugagcu ggagagaccc caagagcggc     1080

agcugguacg uggagacccu ggacgacauc uucgagcagu gggcccacag cgaggaccug     1140

cagagccugc ugcugagagu ggccaacgcc gugagcguga agggcaucua caagcagaug     1200

cccggcugcu ucaacuuccu gagaaagaag cuguucuuca agaccagcug a              1251


<210>  7143
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7143
auggacgagg ccgauagacg gcugcuccgc agaugccggc ugcgccuugu ggaggaacug       60

caggucgacc aacucuggga ugcucugcuu agcagagaac uguuccggcc ccacaugauc      120

gaggacauuc agcgcgccgg cuccgggucu agacgggauc aggcgcgcca gcucaucauu      180

gaccuggaaa ccagaggaag ccaagcucug ccucucuuua ucuccugucu ggaggauaca      240

ggccaggaca ugcuugccuc uuuccugcgg acgaaccgcc aggccgcuaa gcucagcaaa      300

ccgacccugg agaaucuuac acccguugug cugagaccug aaauucggaa gcccgaggug      360

cuccgcccug aaacccccag accugucgau aucggguccg gaggcuuugg ggacguggga      420

gcccuggagu cucugcgggg caacgcugau cucgccuaca uccugagcau ggagccgugc      480

ggccauuguc uuauuaucaa uaacguuaau uucugcagag aauccgggcu gcgcacacgg      540

accggaagca acauugacug ugagaaacuc agacgccggu uuucuucccu gcacuucaug      600

guggaaguca agggcgaucu uacagcgaaa aagauggugc uggcccuccu ggagcuggcu      660

cagcaagacc auggggcccu cgacugcugu guugugguca uccugagcca cggaugccag      720

gcuucucauc uucaguuucc cggcgccgug uaugggaccg auggaugucc uguguccguc      780

gaaaagauug uuaauaucuu caacggcacg agcugccccu cucugggcgg gaaaccuaag      840

cucuuuuuca uucaggcgug uggaggcgag caaaaagacc acggguuuga gguggccucc      900

accagccccg aagaugaguc cccgggaucu aauccugaac ccgacgcuac accuuuccag      960

gagggccuga gaaccuuuga ucagcuugac gccaucagcu cccugcccac acccagcgau     1020

aucuucgugu cuuacuccac cuucccuggg uuugucagcu ggcgcgaccc gaagucugga     1080

agcugguaug uggaaacgcu cgaugacauu uucgagcaau gggcucacuc cgaggaucug     1140

cagucucugc uccugcgggu ugccaacgcc gugagcguca aaggcaucua caagcagaug     1200

cccggcugcu uuaauuuccu uagaaagaaa cuguuuuuca agacauccug a              1251


<210>  7144
<211>  1251
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_9__Homo_sapiens__AAH02452

<400>  7144
auggaugaag ccgauagaag acuacuaaga agaugcagau uaagacuagu agaagaguua       60

caaguagacc aacuauggga cgcuuuauua ucaagagaau uauucagacc ccauaugauu      120

gaagauauac aaagagcagg aucaggauca agacgagauc aagcuagaca acuaauaaua      180

gaccuagaaa cuagaggauc acaagcuuua ccacuauuca uaucauguuu ggaagauacg      240

ggacaagaua uguuagccuc auucuuaaga acuaauagac aagcagcaaa acuaucaaaa      300

ccaacauuag aaaacuuaac accaguugua uuacgaccag aaauacgaaa accugaagua      360

cuaagaccag aaacuccccg accaguagac auaggaucag gagguuuugg agacguagga      420

gcacuagaau cauuaagagg uaacgcugau uuagcuuaua uauuaagcau ggaacccugc      480

ggacauuguc uaauaauaaa uaacguaaau uuuuguagag aaucaggauu aagaacgcgc      540

acaggaucua auauagauug ugaaaaauua agaagaagau ucucaagcuu acauuucaug      600

guagaaguaa aaggugaccu aacagcaaaa aaaaugguac uagcauuacu agaauuagcu      660

caacaagauc acggagcacu agauuguugu guaguaguaa uauuaucuca uggaugucaa      720

gcaagucauc uccaauuccc aggugcagua uauggaacag acggaugccc aguaucagua      780

gaaaaaauag uaaauaucuu uaacggaacc ucauguccaa gccuuggagg aaaaccaaaa      840

uuauucuuua uucaagcaug cggaggagaa caaaaagauc acggauuuga agucgcauca      900

acaucaccug aagaugaauc cccaggguca aauccagaac cugacgcaac accuuuccaa      960

gaaggauuaa gaacauucga ucaauuagau gccauaagcu cauuaccaac accaucagau     1020

auauucguaa guuauucaac auucccagga uuuguauccu ggcgagaucc aaaaagugga     1080

aguugguaug uagaaacacu agacgacaua uuugaacaau gggcacauuc agaagaucua     1140

caaucauuac uccuuagagu cgccaaugca guaucuguaa aaggaauaua uaaacaaaug     1200

ccuggauguu uuaauuucuu aagaaaaaaa uuauuuuuua aaacaaguua a              1251


<210>  7145
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__Q9H257

<400>  7145

Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Thr Leu Thr Ser Val Ile Asp Pro Ser Arg Ile Thr Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Thr Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Thr Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Thr Gln Leu Leu Met Thr Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Thr Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Thr Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Thr Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ala Ile Ala Thr Arg Glu Glu Leu His 
        355                 360                 365             


Ala Gln His Ala Arg Gly Leu Gln Glu Lys Asp Ala Leu Arg Lys Gln 
    370                 375                 380                 


Val Arg Glu Leu Gly Glu Lys Ala Asp Glu Leu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Gln Cys Glu Ala Gln Leu Leu Ala Val Glu Gly Arg Leu Arg Arg Gln 
                405                 410                 415     


Gln Leu Glu Thr Leu Val Leu Ser Ser Asp Leu Glu Asp Gly Ser Pro 
            420                 425                 430         


Arg Arg Ser Gln Glu Leu Ser Leu Pro Gln Asp Leu Glu Asp Thr Gln 
        435                 440                 445             


Leu Ser Asp Lys Gly Cys Leu Ala Gly Gly Gly Ser Pro Lys Gln Pro 
    450                 455                 460                 


Phe Ala Ala Leu His Gln Glu Gln Val Leu Arg Asn Pro His Asp Ala 
465                 470                 475                 480 


Gly Leu Ser Ser Gly Glu Pro Pro Glu Lys Glu Arg Arg Arg Leu Lys 
                485                 490                 495     


Glu Ser Phe Glu Asn Tyr Arg Arg Lys Arg Ala Leu Arg Lys Met Gln 
            500                 505                 510         


Lys Gly Trp Arg Gln Gly Glu Glu Asp Arg Glu Asn Thr Thr Gly Ser 
        515                 520                 525             


Asp Asn Thr Asp Thr Glu Gly Ser 
    530                 535     


<210>  7146
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Caspase_9__Homo_sapiens__BAF84770

<400>  7146
augucggacu acgagaacga ugacgagugc uggagcgucc uggagggcuu ccgggugacg       60

cucaccucgg ucaucgaccc cucacgcauc acaccuuacc ugcggcagug caagguccug      120

aaccccgaug augaggagca ggugcucagc gaccccaacc uggucauccg caaacggaaa      180

gugggugugc uccuggacau ccugcagcgg accggccaca agggcuacgu ggccuuccuc      240

gagagccugg agcucuacua cccgcagcug uacaagaagg ucacaggcaa ggagccggcc      300

cgcgucuucu ccaugaucau cgacgcgucc ggggagucag gccugacuca gcugcugaug      360

acugagguca ugaagcugca gaagaaggug caggaccuga ccgcgcugcu gagcuccaaa      420

gaugacuuca ucaaggagcu gcgggugaag gacagccugc ugcgcaagca ccaggagcgu      480

gugcagaggc ucaaggagga gugcgaggcc ggcagccgcg agcucaagcg cugcaaggag      540

gagaacuacg accuggccau gcgccuggcg caccagagug aggagaaggg cgccgcgcuc      600

augcggaacc gugaccugca gcuggagauu gaccagcuca agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acgcugaagc ucaggcacgc cauggagcag      720

cggcccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu ccaggcccgg      780

gugcaggagc uggaggccuc cguccaggag gggaagcugg acaggagcag ccccuacauc      840

cagguacugg aggaggacug gcggcaggcg cugcgggacc accaggagca ggccaacacc      900

aucuucuccc ugcgcaagga ccuccgccag ggcgaggccc gacgccuccg gugcauggag      960

gagaaggaga uguucgagcu gcagugccug gcacuacgua aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu gcugcagaug gaggaggucg ccauugagcg ggaccaggcc     1080

auagccacgc gggaggagcu gcacgcacag cacgcccggg gccugcagga gaaggacgcg     1140

cugcgcaagc aggugcggga gcugggcgag aaggcggaug agcugcagcu gcagguguuc     1200

cagugugagg cgcagcuacu ggccguggag ggcaggcuca ggcggcagca gcuggagacg     1260

cucguccuga gcuccgaccu ggaagauggc ucacccagga ggucccagga gcucucacuc     1320

ccccaggacc uggaggacac ccagcucuca gacaaaggcu gccuugccgg cggggggagc     1380

ccgaaacagc ccuuugcagc ucugcaccag gagcagguuu ugcggaaccc ccaugacgca     1440

ggccugagca gcggggagcc gcccgagaag gagcggcggc gccucaaaga gaguuuugag     1500

aacuaccgca ggaagcgcgc ccucaggaag augcagaaag gauggcggca gggggaggag     1560

gaccgggaga acaccacggg cagcgacaac accgacacug agggcuccua g              1611


<210>  7147
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7147
augagcgacu acgagaacga cgacgagugc ugguccgugc uggagggcuu ccgcgugacc       60

cucaccagcg ugaucgaccc cucccggauc acgccguacc ugcgccagug caaggugcug      120

aaccccgacg acgaggagca gguccucagc gaccccaacc uggugauccg gaagcgcaag      180

gugggggucc ugcucgacau ccugcagcgg accggccaca agggguacgu ggccuuccug      240

gagucccucg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagccggcc      300

cgcgucuuca gcaugaucau cgacgcgucc ggggagagcg gccucaccca gcugcugaug      360

acggagguga ugaagcucca gaagaaggug caggaccuga ccgcccugcu cuccagcaag      420

gacgacuuca ucaaggagcu gcgggucaag gacucccugc uccgcaagca ccaggagcgg      480

gugcagcgcc ugaaggagga gugcgaggcc ggcagccggg agcugaagcg cugcaaggag      540

gagaacuacg accucgccau gcggcuggcc caccaguccg aggagaaggg ggcggcccug      600

augcgcaacc gggaccucca gcuggagauc gaccagcuga agcacagccu caugaaggcc      660

gaggacgacu gcaaggugga gcgcaagcac acccugaagc ugcggcacgc cauggagcag      720

cgccccuccc aggagcuccu gugggagcug cagcaggaga aggcgcuccu gcaggcccgg      780

guccaggagc uggaggccag cgugcaggag ggcaagcucg accgcuccag ccccuacauc      840

caggugcugg aggaggacug gcggcaggcc cugcgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccugcggcag ggggaggcgc gccggcugcg cugcauggag      960

gagaaggaga uguucgagcu ccagugccug gcccugcgga aggacagcaa gauguacaag     1020

gaccgcaucg aggccauccu ccugcagaug gaggaggucg ccaucgagcg ggaccaggcc     1080

aucgcgacgc gcgaggagcu gcacgcccag cacgcccggg gccugcagga gaaggacgcc     1140

cuccgcaagc agguccggga gcugggggag aaggccgacg agcugcagcu ccagguguuc     1200

cagugcgagg cgcagcugcu ggccguggag ggccgccucc ggcgccagca gcuggagacc     1260

cuggugcuca gcuccgaccu ggaggacggc agcccccggc gcucccagga gcugagccuc     1320

ccgcaggacc uggaggacac ccagcugucc gacaaggggu gccucgccgg cgggggcagc     1380

cccaagcagc ccuucgccgc ccugcaccag gagcaggucc ugcggaaccc ccacgacgcg     1440

ggccucucca gcggggagcc gcccgagaag gagcgccggc gccugaagga guccuucgag     1500

aacuaccgcc ggaagcgcgc ccugcggaag augcagaagg gcuggcgcca gggggaggag     1560

gaccgggaga acaccacggg cagcgacaac accgacaccg agggguccug a              1611


<210>  7148
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7148
auguccgacu acgagaacga cgacgagugc ugguccgucc ucgagggcuu ccgcgucacc       60

cucaccuccg ucaucgaccc cucccgcauc acccccuacc uccgccagug caagguccuc      120

aaccccgacg acgaggagca gguccucucc gaccccaacc ucgucauccg caagcgcaag      180

gucggcgucc uccucgacau ccuccagcgc accggccaca agggcuacgu cgccuuccuc      240

gagucccucg agcucuacua cccccagcuc uacaagaagg ucaccggcaa ggagcccgcc      300

cgcgucuucu ccaugaucau cgacgccucc ggcgaguccg gccucaccca gcuccucaug      360

accgagguca ugaagcucca gaagaagguc caggaccuca ccgcccuccu cuccuccaag      420

gacgacuuca ucaaggagcu ccgcgucaag gacucccucc uccgcaagca ccaggagcgc      480

guccagcgcc ucaaggagga gugcgaggcc ggcucccgcg agcucaagcg cugcaaggag      540

gagaacuacg accucgccau gcgccucgcc caccaguccg aggagaaggg cgccgcccuc      600

augcgcaacc gcgaccucca gcucgagauc gaccagcuca agcacucccu caugaaggcc      660

gaggacgacu gcaaggucga gcgcaagcac acccucaagc uccgccacgc cauggagcag      720

cgccccuccc aggagcuccu cugggagcuc cagcaggaga aggcccuccu ccaggcccgc      780

guccaggagc ucgaggccuc cguccaggag ggcaagcucg accgcuccuc ccccuacauc      840

cagguccucg aggaggacug gcgccaggcc cuccgcgacc accaggagca ggccaacacc      900

aucuucuccc uccgcaagga ccuccgccag ggcgaggccc gccgccuccg cugcauggag      960

gagaaggaga uguucgagcu ccagugccuc gcccuccgca aggacuccaa gauguacaag     1020

gaccgcaucg aggccauccu ccuccagaug gaggaggucg ccaucgagcg cgaccaggcc     1080

aucgccaccc gcgaggagcu ccacgcccag cacgcccgcg gccuccagga gaaggacgcc     1140

cuccgcaagc agguccgcga gcucggcgag aaggccgacg agcuccagcu ccaggucuuc     1200

cagugcgagg cccagcuccu cgccgucgag ggccgccucc gccgccagca gcucgagacc     1260

cucguccucu ccuccgaccu cgaggacggc uccccccgcc gcucccagga gcucucccuc     1320

ccccaggacc ucgaggacac ccagcucucc gacaagggcu gccucgccgg cggcggcucc     1380

cccaagcagc ccuucgccgc ccuccaccag gagcaggucc uccgcaaccc ccacgacgcc     1440

ggccucuccu ccggcgagcc ccccgagaag gagcgccgcc gccucaagga guccuucgag     1500

aacuaccgcc gcaagcgcgc ccuccgcaag augcagaagg gcuggcgcca gggcgaggag     1560

gaccgcgaga acaccaccgg cuccgacaac accgacaccg agggcuccug a              1611


<210>  7149
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7149
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cucaaggauu acuccuuauc uucggcagug uaaggugcug      120

aauccagacg augaggagca aguauugagu gacccgaacu uagugauacg caaacgaaag      180

gucggggugc ugcuagauau ccuccagcgu acgggacaca aagguuacgu ugccuuucug      240

gaaagccuug agcuguauua cccccaguug uauaagaaag ugaccggcaa ggagccugcu      300

agagucuucu ccaugauuau cgacgcaucu ggggaaucgg gacucacaca gcugcugaug      360

acugagguga ugaagcucca aaagaaggua caggauuuaa ccgcccugcu uucaagcaaa      420

gacgauuuua uuaaggaauu gaggguuaaa gacagucugc uacggaagca ucaggagcgc      480

gugcagagac ucaaggagga augcgaggcg ggcuccaggg aacugaaacg guguaaggag      540

gaaaauuacg aucuugcuau gcgccuggcc caccaaucug aggagaaagg ugcagccuug      600

augcgaaaca gagaccucca gcuggaaauc gaccaguuaa agcauagccu gaugaaagcu      660

gaggaugacu gcaaggucga aaggaaacac acacucaaac uucggcaugc aauggagcag      720

cguccauccc aagaacuguu gugggagcua cagcaggaga aggcccugcu ccaagcucgc      780

gugcaggaac uggaggccuc agugcaggaa gggaaacuug auagaaguag ccccuauaua      840

cagguccugg aggaagacug gaggcaagcg uugcgggauc accaggagca ggcaaauacc      900

aucuucucuc uccgaaagga ccugcgccag ggagaggcca gaagguuacg guguauggaa      960

gagaaagaaa uguuugagcu gcaaugccua gcucuccgca aggauuccaa aauguacaag     1020

gacagaauug aggccauccu gcuucagaug gaagagguug caauugaaag ggaucaggcu     1080

aucgccacuc gugaggaauu gcacgcgcag caugcccggg gccugcaaga gaaggacgca     1140

cuccgaaaac aggugagaga gcugggcgaa aaggcugaug agcuucagcu gcagguauuc     1200

caaugugaag cccaguugcu cgcuguggag gggaggcugc gccggcagca auuagaaaca     1260

cugguccuau caagcgaccu cgaggacgga aguccuagaa ggucucagga gcugucccuu     1320

ccacaggauu uggaagacac ccagcugagc gauaaagguu gccucgccgg cgggggaucg     1380

cccaagcaac cuuuugcagc ccugcaccag gaacaggugu uacgcaaccc acaugacgcu     1440

ggccugucuu ccggugaacc gcccgagaaa gaacgacggc gucuuaagga gucauucgag     1500

aauuacagaa ggaagcgcgc guugcggaaa augcagaagg gguggagaca aggagaagag     1560

gauagggaaa acacgacugg cagugacaau accgauacag agggcagcug a              1611


<210>  7150
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7150
augagcgacu acgagaacga cgacgagugc uggagcgugc uggagggcuu cagagugacc       60

cugaccagcg ugaucgaccc cagcagaauc acccccuacc ugagacagug caaggugcug      120

aaccccgacg acgaggagca ggugcugagc gaccccaacc uggugaucag aaagagaaag      180

gugggcgugc ugcuggacau ccugcagaga accggccaca agggcuacgu ggccuuccug      240

gagagccugg agcuguacua cccccagcug uacaagaagg ugaccggcaa ggagcccgcc      300

agaguguuca gcaugaucau cgacgccagc ggcgagagcg gccugaccca gcugcugaug      360

accgagguga ugaagcugca gaagaaggug caggaccuga ccgcccugcu gagcagcaag      420

gacgacuuca ucaaggagcu gagagugaag gacagccugc ugagaaagca ccaggagaga      480

gugcagagac ugaaggagga gugcgaggcc ggcagcagag agcugaagag augcaaggag      540

gagaacuacg accuggccau gagacuggcc caccagagcg aggagaaggg cgccgcccug      600

augagaaaca gagaccugca gcuggagauc gaccagcuga agcacagccu gaugaaggcc      660

gaggacgacu gcaaggugga gagaaagcac acccugaagc ugagacacgc cauggagcag      720

agacccagcc aggagcugcu gugggagcug cagcaggaga aggcccugcu gcaggccaga      780

gugcaggagc uggaggccag cgugcaggag ggcaagcugg acagaagcag ccccuacauc      840

caggugcugg aggaggacug gagacaggcc cugagagacc accaggagca ggccaacacc      900

aucuucagcc ugagaaagga ccugagacag ggcgaggcca gaagacugag augcauggag      960

gagaaggaga uguucgagcu gcagugccug gcccugagaa aggacagcaa gauguacaag     1020

gacagaaucg aggccauccu gcugcagaug gaggaggugg ccaucgagag agaccaggcc     1080

aucgccacca gagaggagcu gcacgcccag cacgccagag gccugcagga gaaggacgcc     1140

cugagaaagc aggugagaga gcugggcgag aaggccgacg agcugcagcu gcagguguuc     1200

cagugcgagg cccagcugcu ggccguggag ggcagacuga gaagacagca gcuggagacc     1260

cuggugcuga gcagcgaccu ggaggacggc agccccagaa gaagccagga gcugagccug     1320

ccccaggacc uggaggacac ccagcugagc gacaagggcu gccuggccgg cggcggcagc     1380

cccaagcagc ccuucgccgc ccugcaccag gagcaggugc ugagaaaccc ccacgacgcc     1440

ggccugagca gcggcgagcc ccccgagaag gagagaagaa gacugaagga gagcuucgag     1500

aacuacagaa gaaagagagc ccugagaaag augcagaagg gcuggagaca gggcgaggag     1560

gacagagaga acaccaccgg cagcgacaac accgacaccg agggcagcug a              1611


<210>  7151
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7151
augagcgacu acgagaacga ugacgaaugc ugguccgugc uggagggcuu cagagucacc       60

cucacaucug uuaucgaucc cagccggauu acgccuuauc ugcgccagug uaaggugcuu      120

aauccggacg augaggaaca agugcugucc gaccccaacc ucgucaucag aaaacggaag      180

guggggguuc ugcuugauau ucugcagcgc accggacaca aaggcuacgu ggccuuucuc      240

gaaucucugg agcuguauua cccucagcuc uauaagaaag ucacagggaa ggagcccgcu      300

agaguguuca gcaugaucau ugacgccucc ggagaaucug gccugaccca gcuucugaug      360

acagagguua ugaagcucca gaaaaaggug caagaucuga ccgcgcuucu gagcuccaaa      420

gacgauuuua ucaaggaacu ccgggucaaa gacagccugc ugcgcaagca ucaggagaga      480

gugcagcggc ucaaggagga augcgaggcu gggucucgcg aacugaaaag auguaaggag      540

gaaaauuacg aucuugccau gcggcuggcc caccaauccg aggagaaagg agcugcccuc      600

augcgcaaca gagaccugca gcuugaaauc gaccagcuga agcauagccu caugaaagcu      660

gaggaugacu gcaaggugga acggaaacac acacugaagc ugcgccaugc cauggagcag      720

agaccuucuc aagaacuccu gugggagcuu cagcaggaga aggcgcugcu ccaagcccgg      780

guccaggaac uggaggcuuc cguucaggaa ggcaaacuug auagaagcuc ucccuauauu      840

caggugcugg aggaagacug gcgccaagcc cuccgggauc accaggagca ggcuaauacc      900

aucuucuccc ugagaaagga ccugcgccag ggcgaggccc ggagacuccg cuguauggaa      960

gagaaagaaa uguuugagcu gcaaugccuu gcgcugcgga aggauagcaa aauguacaag     1020

gacagaauug aggccauccu ccugcagaug gaagaggugg cuauugaacg cgaucaggcc     1080

aucgcuacgc gggaggaacu gcacgcccag caugccagag ggcuucaaga gaaggacgcu     1140

cuccgcaaac agguccggga gcugggagaa aaggcggaug agcugcagcu ccagguguuc     1200

caaugugaag cccagcugcu ugcuguugag ggcagacugc ggcgccagca acucgaaacc     1260

cuggugcugu ccucugaccu ugaggacggg agcccuagac ggucccagga gcucagccug     1320

ccgcaggauc uggaagacac acagcucucu gauaaaggau gccuggccgg cgggggaucc     1380

cccaagcaac cuuuugccgc ccuucaccag gagcaggucc ugagaaaccc ccaugacgcu     1440

ggccucagcu cuggcgaacc ucccgagaaa gaacgccgga gacugaagga gagcuucgag     1500

aauuaccgca gaaagcgggc gcugcgcaaa augcagaagg gguggagaca aggagaagag     1560

gaucgggaaa acaccacagg cuccgacaau accgauacgg aggggucuug a              1611


<210>  7152
<211>  1611
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Caspase_9__Homo_sapiens__BAF84770

<400>  7152
augagugacu acgaaaacga cgaugaaugu uggagcgugu uagaaggauu uaggguaacu       60

uugaccucag uaauugaccc aucaagaaua acaccauauc ugagacaaug uaaaguacua      120

aacccagaug augaagaaca aguacuauca gauccaaauc uaguaauaag aaaaaggaaa      180

guaggaguac uacuugauau ucugcaaaga acaggacaua aaggauacgu ugcauuucuc      240

gagucauuag aacuauauua cccacaacua uauaaaaaag uaacaggaaa agaaccagca      300

agaguuuuca guaugauaau agaugcaagu ggagaaagug gacuaacaca acuauugaug      360

accgaaguaa ugaaauugca aaaaaaagua caagacuuaa cagcauuauu gucaucaaaa      420

gacgauuuua uaaaagaacu aagaguaaaa gacagucuac uaagaaaaca ccaagaacga      480

guacaacgac uaaaagaaga augcgaagca ggcaguagag aauuaaaaag augcaaagaa      540

gaaaacuaug aucuagcaau gagacuagca caucaaagug aagaaaaagg agccgcauua      600

augcggaauc gagauuuaca acucgaaaua gaccaguuaa aacacagucu aaugaaagcg      660

gaagaugauu guaaaguaga acgcaaacac acucuuaaac ucagacacgc cauggagcaa      720

aggccaaguc aagaacuauu augggaauua caacaagaaa aagcucuauu acaagcacga      780

guacaagaac uagaagcauc cguacaagaa gggaaacuug auagaaguag uccauauaua      840

caaguacuag aagaagacug gagacaagca uugcgagacc aucaggaaca agcaaacaca      900

auauucaguc uuaggaaaga ucuaagacag ggggaagcac gaagacuuag augcauggaa      960

gaaaaagaaa uguuugaacu acaaugccug gcccuaagaa aagacucaaa aauguauaaa     1020

gauagaauug aagcaauauu acuucaaaug gaagaagugg caauugaaag agaccaagca     1080

auagcaacuc gagaagaauu acacgcacaa caugcaaggg gauuacaaga aaaagaugcc     1140

uuaagaaaac aaguaagaga acuaggggaa aaagcagaug aacuccaauu acaaguauuc     1200

cagugcgagg cacaacuccu agcuguagaa ggaagauuaa gaaggcagca acuagaaaca     1260

uuaguauuaa gcucagacuu agaagauggg ucaccaagac gaagccaaga auuaucuuua     1320

ccgcaagacc uagaagacac acaguuauca gauaagggau gcuuagccgg uggaggaagc     1380

ccgaaacaac cauuugcagc guuacaucaa gaacaagugc uaagaaaccc acaugaugcu     1440

ggacuaucaa gcggagaacc accagaaaaa gaaagaagaa gacuaaaaga aaguuucgaa     1500

aauuauagga gaaaaagagc acuaagaaaa augcaaaaag guuggagaca gggagaagaa     1560

gauagagaaa acacgacagg aagcgauaac acugacacag aagggucaua a              1611


<210>  7153
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__A0A024R9B7

<400>  7153

Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala 
1               5                   10                  15      


Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly 
            20                  25                  30          


Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala 
        35                  40                  45              


Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu 
    50                  55                  60                  


Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys 
65                  70                  75  


<210>  7154
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__EAW91792

<400>  7154
auggcucccg aaguuuugcc aaaaccucgg augcguggcc uucuggccag gcgucugcga       60

aaucauaugg cuguagcauu cgugcuaucc cuggggguug cagcuuugua uaaguuucgu      120

guggcugauc aaagaaagaa ggcauacgca gauuucuaca gaaacuacga ugucaugaaa      180

gauuuugagg agaugaggaa ggcugguauc uuucagagug uaaaguaa                   228


<210>  7155
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7155
auggcccccg aggugcugcc gaagccccgc augcggggcc uccuggcccg ccggcugcgc       60

aaccacaugg cggucgccuu cgugcucagc cugggggugg ccgcccugua caaguuccgg      120

gucgccgacc agcgcaagaa ggcguacgcc gacuucuacc ggaacuacga cgugaugaag      180

gacuucgagg agaugcgcaa ggccggcauc uuccaguccg ugaaguga                   228


<210>  7156
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7156
auggcccccg agguccuccc caagccccgc augcgcggcc uccucgcccg ccgccuccgc       60

aaccacaugg ccgucgccuu cguccucucc cucggcgucg ccgcccucua caaguuccgc      120

gucgccgacc agcgcaagaa ggccuacgcc gacuucuacc gcaacuacga cgucaugaag      180

gacuucgagg agaugcgcaa ggccggcauc uuccaguccg ucaaguga                   228


<210>  7157
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7157
auggcccccg aggugcugcc uaagccaaga augaggggcc uccuugcucg gcgccugcga       60

aaccacaugg cagucgccuu cguuuugagc uuaggggugg cggcucugua caaauuucgu      120

guagccgacc agagaaagaa agcauaugcc gauuucuaca ggaauuauga cgugaugaag      180

gauuuugaag agaugcggaa agcuggaauc uuccaauccg ucaaguga                   228


<210>  7158
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7158
auggcccccg aggugcugcc caagcccaga augagaggcc ugcuggccag aagacugaga       60

aaccacaugg ccguggccuu cgugcugagc cugggcgugg ccgcccugua caaguucaga      120

guggccgacc agagaaagaa ggccuacgcc gacuucuaca gaaacuacga cgugaugaag      180

gacuucgagg agaugagaaa ggccggcauc uuccagagcg ugaaguga                   228


<210>  7159
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7159
auggcccccg aggugcugcc uaagccgaga augcggggcc uccuggcucg cagacuucgg       60

aaccacaugg ccgucgcguu cguucugagc cucggggugg cugcccugua caaauuucgc      120

guggccgacc agagaaagaa ggcuuaugcc gauuucuacc ggaauuauga cgucaugaaa      180

gauuuugaag agaugcgcaa agcuggaauc uuccaauccg ugaaguga                   228


<210>  7160
<211>  228
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__EAW91792

<400>  7160
auggcaccag aaguacuacc aaaaccaaga augagaggac uauuagcaag aagauuaaga       60

aaucacaugg caguagcauu uguauuaagc uuaggaguag cagcacuaua uaaauuuaga      120

guagcagauc aaagaaaaaa agcauaugca gauuucuaua gaaauuacga uguaaugaaa      180

gauuucgaag aaaugagaaa agcaggaaua uuucaaucag uaaaauaa                   228


<210>  7161
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__A0A024RAP6

<400>  7161

Met Cys Leu Tyr Phe Gly Ser Ala Phe Ala Thr Pro Phe Leu Val Val 
1               5                   10                  15      


Arg His Gln Leu Leu Lys Thr 
            20              


<210>  7162
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__EAW95922

<400>  7162
auguguuugu acuuuggauc ugcauuugcu acacccuucc uuguaguaag acaccaacug       60

cuuaaaacau aa                                                           72


<210>  7163
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7163
augugccugu acuucggcag cgccuucgcc acccccuucc ucgugguccg ccaccagcug       60

cugaagaccu ga                                                           72


<210>  7164
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7164
augugccucu acuucggcuc cgccuucgcc acccccuucc ucgucguccg ccaccagcuc       60

cucaagaccu ga                                                           72


<210>  7165
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7165
augugccugu acuucggcag cgccuuugcu acccccuucc ucguggucag acaccagcuu       60

cugaagacau ga                                                           72


<210>  7166
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7166
augugccugu acuucggcag cgccuucgcc acccccuucc ugguggugag acaccagcug       60

cugaagaccu ga                                                           72


<210>  7167
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7167
augugccugu acuucggcag cgccuuugcu acccccuucc ucguggucag acaccagcug       60

cuuaagacau ga                                                           72


<210>  7168
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__EAW95922

<400>  7168
augugucuau auuucgguuc agcuuucgcu acaccuuucc uuguaguuag acaucaacuu       60

cuaaaaacau aa                                                           72


<210>  7169
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__A0A024RBN6

<400>  7169

Met Ile Val Leu Arg Leu Met Pro Val Gly Gly Arg Arg Pro Ile Val 
1               5                   10                  15      


Thr Ser Phe Gly Gly Cys Ser Thr Ala Pro Arg Ala Asn Phe Pro Leu 
            20                  25                  30          


Pro Leu Pro Ala Leu Arg Gln Ser Arg Ser Lys Met Ala Val Val Gly 
        35                  40                  45              


Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser Arg Pro Gln Leu Gly 
    50                  55                  60                  


Arg Pro Met Ser Ser Gly Ala His Gly Glu Glu Gly Ser Ala Arg Met 
65                  70                  75                  80  


Trp Lys Thr Leu Thr Phe Phe Val Ala Leu Pro Gly Val Ala Val Ser 
                85                  90                  95      


Met Leu Asn Val Tyr Leu Lys Ser His His Gly Glu His Glu Arg Pro 
            100                 105                 110         


Glu Phe Ile Ala Tyr Pro His Leu Arg Ile Arg Thr Lys Pro Phe Pro 
        115                 120                 125             


Trp Gly Asp Gly Asn His Thr Leu Phe His Asn Pro His Val Asn Pro 
    130                 135                 140                 


Leu Pro Thr Gly Tyr Glu Asp Glu 
145                 150         


<210>  7170
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__EAW98190

<400>  7170
augauagugc ucagguuaau gccaguggga gggcggcgcc caauaguaac uuccuuugga       60

gguuguagua ccgcccccag agccaauuuu ccacuuccgc uuccggcgcu gcggcagucc      120

agaucaaaaa uggcgguagu uggugugucc ucgguuucuc ggcugcuggg ucggucccgc      180

ccacagcugg ggcggccuau gucgaguggc gcccauggcg aagagggcuc agcucgcaug      240

uggaagacuc ucaccuucuu cgucgcgcuc cccggggugg cagucagcau gcugaaugug      300

uaccugaagu cgcaccacgg agagcacgag agacccgagu ucaucgccua cccccaucuc      360

cgcaucagga ccaagccguu ucccugggga gaugguaacc auacucuauu ccauaacccu      420

caugugaauc cacuuccaac uggcuacgaa gaugaauaa                             459


<210>  7171
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7171
augaucgugc ugcgccugau gcccgucggc gggcggcgcc cgaucgugac cagcuucggc       60

gggugcucca ccgcgccccg ggccaacuuc ccccugcccc ugccggcccu ccgccagagc      120

cgguccaaga uggccguggu cggcgugagc uccgugagcc gccugcuggg gcggucccgc      180

ccccagcucg gccggcccau gagcuccggc gcccacgggg aggagggcag cgcccgcaug      240

uggaagacgc ugaccuucuu cgucgcccug cccggggugg cgguguccau gcucaacguc      300

uaccucaaga gccaccacgg cgagcacgag cggccggagu ucaucgccua cccccaccuc      360

cgcauccgga ccaagcccuu ccccuggggc gacgggaacc acacccuguu ccacaacccg      420

cacgugaacc cccugcccac gggcuacgag gacgaguga                             459


<210>  7172
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7172
augaucgucc uccgccucau gcccgucggc ggccgccgcc ccaucgucac cuccuucggc       60

ggcugcucca ccgccccccg cgccaacuuc ccccuccccc uccccgcccu ccgccagucc      120

cgcuccaaga uggccgucgu cggcgucucc uccgucuccc gccuccucgg ccgcucccgc      180

ccccagcucg gccgccccau guccuccggc gcccacggcg aggagggcuc cgcccgcaug      240

uggaagaccc ucaccuucuu cgucgcccuc cccggcgucg ccgucuccau gcucaacguc      300

uaccucaagu cccaccacgg cgagcacgag cgccccgagu ucaucgccua cccccaccuc      360

cgcauccgca ccaagcccuu ccccuggggc gacggcaacc acacccucuu ccacaacccc      420

cacgucaacc cccuccccac cggcuacgag gacgaguga                             459


<210>  7173
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7173
augaucgugc ugagacucau gcccgucggc gggaggcggc cuauuguuac cagcuucgga       60

gguugcucca cagccccacg cgcuaacuuu ccgcuucccc ugccugcauu gcgacagucu      120

cguucaaaga uggccguggu aggcgugagu agcgucucca gauuacuggg gaggucucgg      180

ccacaacuag gacgccccau gucgucaggc gcgcacggug aggaagggag cgcuagaaug      240

uggaaaacuc ucacguucuu uguggcccug ccuggaguug cagugaguau gcuuaauguc      300

uaccugaagu cccaucacgg cgagcaugaa aggccagagu ucauagccua uccccacuug      360

cggauccgca ccaaaccuuu uccauggggc gacgggaacc auacacucuu ccacaauccg      420

cacgugaacc cccugccuac uggauacgaa gaugaguga                             459


<210>  7174
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7174
augaucgugc ugagacugau gcccgugggc ggcagaagac ccaucgugac cagcuucggc       60

ggcugcagca ccgcccccag agccaacuuc ccccugcccc ugcccgcccu gagacagagc      120

agaagcaaga uggccguggu gggcgugagc agcgugagca gacugcuggg cagaagcaga      180

ccccagcugg gcagacccau gagcagcggc gcccacggcg aggagggcag cgccagaaug      240

uggaagaccc ugaccuucuu cguggcccug cccggcgugg ccgugagcau gcugaacgug      300

uaccugaaga gccaccacgg cgagcacgag agacccgagu ucaucgccua cccccaccug      360

agaaucagaa ccaagcccuu ccccuggggc gacggcaacc acacccuguu ccacaacccc      420

cacgugaacc cccugcccac cggcuacgag gacgaguga                             459


<210>  7175
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7175
augaucgugc ugagacucau gcccgucggc gggcggcgcc cuauuguuac cagcuucgga       60

ggcugcucca cagccccgag agcuaacuuu ccccugccuc uucccgcccu gcggcagucu      120

cgcagcaaga uggcgguggu gggggucucc ucugugagca gacuccuggg acggucccgc      180

ccucaacuug gcagacccau gucuagcggg gcucacggag aggaaggcuc cgcccggaug      240

uggaaaacgc ugaccuucuu uguugcccuc ccuggcgugg cugucagcau gcugaaugug      300

uaccugaagu cucaucacgg ggagcaugaa cgcccggagu ucaucgccua uccccaccuc      360

cggauuagaa caaaaccuuu ucccugggga gacggcaacc auacccuguu ccacaauccu      420

cacguuaacc cccuuccgac aggguacgaa gaugaguga                             459


<210>  7176
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__EAW98190

<400>  7176
augauaguau uaagacuaau gccaguagga ggaagaagac caauaguaac aucauucgga       60

ggaugcucaa cagcaccaag agcaaacuuc ccacuaccac uaccagcacu aagacaauca      120

agaucaaaaa uggcaguagu aggaguauca ucaguaagua gacuauuagg aagaucaaga      180

ccacaacuag gaagaccaau gucaucagga gcacacggag aagaaggauc agcaagaaug      240

uggaaaacac uaacauucuu cguagcauua ccaggagucg caguaucaau guuaaacgua      300

uacuuaaaau cacaccacgg cgaacacgaa agaccagaau uuauagcaua cccacacuua      360

agaauacgaa caaaaccauu cccaugggga gauggaaauc acacacuauu ccacaaccca      420

cacguaaacc cacuaccaac aggauacgaa gacgaauaa                             459


<210>  7177
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__A0A024RBY9

<400>  7177

Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn 
1               5                   10                  15      


Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met 
            20                  25                  30          


Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys 
        35                  40                  45              


Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val 
    50                  55                  60                  


Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln 
                85                  90                  95      


Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala 
            100                 105                 110         


Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn 
        115                 120                 125             


Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln 
    130                 135                 140                 


Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln 
145                 150                 155                 160 


Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys 
                165                 170                 175     


Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr 
            180                 185                 190         


Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe 
        195                 200                 205             


Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr 
    210                 215                 220                 


Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe 
225                 230                 235                 240 


Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp 
                245                 250                 255     


Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser 
            260                 265             


<210>  7178
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__EAW98784

<400>  7178
auggguuugu cuccaucugc uccugcuguu gcaguucagg ccucaaaugc uucagcgucc       60

ccaccuucag gaugcccgau gcaugaaggg aaaaugaaag gcuguccagu gaauacagag      120

ccaucuggcc caaccuguga gaagaaaaca uacucugugc cugcccacca ggaacgcgcc      180

uaugaguacg uggagugucc cauuaggggc acugcggcug agaauaagga gaaccuagau      240

ccuucaaauc ugaugccacc accaaaucaa acaccagcuc cagaucagcc auuugcauug      300

ucuacuguca gagaagaguc auccauuccg agagcagauu cagagaaaaa guggguuuac      360

ccuucugagc agauguucug gaaugcaaug uuaaagaaag gguggaagug gaaggaugag      420

gauaucaguc agaaggauau guauaauauc auuagaauuc acaaucagaa uaacgagcag      480

gcuuggaagg agauuuugaa gugggaagcc cuucaugcug cagagugucc uuguggucca      540

ucauugaucc gguuuggagg gaaagcaaaa gaguauucac caagggcacg aauucguucc      600

uggauggggu augaguugcc uuuugauagg cacgauugga ucauaaaccg uugcgggaca      660

gaaguuagau augugauuga uuauuaugau gguggugaag ucaacaagga cuaccaguuc      720

accauccugg acguccgucc ugccuuagau ucacuuucgg caguauggga cagaaugaaa      780

gucgcuuggu ggcguuggac cucguaa                                          807


<210>  7179
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7179
augggccuga gccccuccgc cccggccgug gcgguccagg ccagcaacgc cuccgccagc       60

ccgcccuccg ggugccccau gcacgagggc aagaugaagg ggugccccgu gaacaccgag      120

cccagcggcc cgaccugcga gaagaagacg uacuccgugc ccgcccacca ggagcgcgcg      180

uacgaguacg ucgagugccc cauccggggg accgccgccg agaacaagga gaaccucgac      240

cccagcaacc ugaugccccc gcccaaccag acccccgccc ccgaccagcc cuucgcgcug      300

uccaccgugc gcgaggagag cuccaucccg cgggccgaca gcgagaagaa guggguguac      360

cccuccgagc agauguucug gaacgccaug cucaagaagg gcuggaagug gaaggacgag      420

gacaucagcc agaaggacau guacaacauc auccgcaucc acaaccagaa caacgagcag      480

gccuggaagg agauccugaa gugggaggcc cugcacgcgg ccgagugccc cugcggcccc      540

ucccucaucc gguucggggg caaggccaag gaguacagcc cgcgcgcccg gauccgcucc      600

uggauggggu acgagcugcc cuucgaccgg cacgacugga ucaucaaccg cugcggcacg      660

gagguccggu acgugaucga cuacuacgac gggggcgagg ugaacaagga cuaccaguuc      720

accauccugg acguccgccc cgcccucgac agccuguccg cgguguggga ccggaugaag      780

guggccuggu ggcgcuggac cagcuga                                          807


<210>  7180
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7180
augggccucu cccccuccgc ccccgccguc gccguccagg ccuccaacgc cuccgccucc       60

ccccccuccg gcugccccau gcacgagggc aagaugaagg gcugccccgu caacaccgag      120

cccuccggcc ccaccugcga gaagaagacc uacuccgucc ccgcccacca ggagcgcgcc      180

uacgaguacg ucgagugccc cauccgcggc accgccgccg agaacaagga gaaccucgac      240

cccuccaacc ucaugccccc ccccaaccag acccccgccc ccgaccagcc cuucgcccuc      300

uccaccgucc gcgaggaguc cuccaucccc cgcgccgacu ccgagaagaa gugggucuac      360

cccuccgagc agauguucug gaacgccaug cucaagaagg gcuggaagug gaaggacgag      420

gacaucuccc agaaggacau guacaacauc auccgcaucc acaaccagaa caacgagcag      480

gccuggaagg agauccucaa gugggaggcc cuccacgccg ccgagugccc cugcggcccc      540

ucccucaucc gcuucggcgg caaggccaag gaguacuccc cccgcgcccg cauccgcucc      600

uggaugggcu acgagcuccc cuucgaccgc cacgacugga ucaucaaccg cugcggcacc      660

gagguccgcu acgucaucga cuacuacgac ggcggcgagg ucaacaagga cuaccaguuc      720

accauccucg acguccgccc cgcccucgac ucccucuccg ccgucuggga ccgcaugaag      780

gucgccuggu ggcgcuggac cuccuga                                          807


<210>  7181
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7181
augggccuga gccccuccgc cccugcugug gcaguccagg ccucuaacgc gucagcuagu       60

ccaccgagcg ggugccccau gcacgaggga aagaugaaag guuguccugu uaauaccgaa      120

ccauccggcc ccacaugcga gaagaaaacu uacucugugc cugcccauca agaaagagca      180

uaugaguacg uagaaugucc aaucaggggg acggccgcug agaacaagga gaaucucgac      240

cccucgaacc uuaugccucc accgaaucag acccccgcac cugaucagcc auucgcccug      300

ucaacagugc gggaagagag caguauuccc cgcgcugacu ccgagaaaaa gugggucuau      360

ccuucugaac agauguuuug gaacgccaug uugaagaaag gauggaagug gaaagaugag      420

gacauaagcc aaaaggauau guacaauauc auucgaaucc acaaccagaa uaacgaacag      480

gcguggaaag agauuuuaaa gugggaagca cugcaugccg cugagugccc auguggcccc      540

ucccuaaucc guuucggugg gaaggccaaa gaauauucac cgagagcaag gauacggagu      600

uggaugggau acgagcuccc uuuugaccgc cacgauugga ucauuaauag augcggcacu      660

gaggugaggu auguuaucga cuacuacgau ggcggggaag ugaacaagga cuaucaguuc      720

accauucugg auguccggcc cgcucuugac agccugucug ccguguggga ucgcaugaaa      780

guagcguggu ggcgauggac auccuga                                          807


<210>  7182
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7182
augggccuga gccccagcgc ccccgccgug gccgugcagg ccagcaacgc cagcgccagc       60

ccccccagcg gcugccccau gcacgagggc aagaugaagg gcugccccgu gaacaccgag      120

cccagcggcc ccaccugcga gaagaagacc uacagcgugc ccgcccacca ggagagagcc      180

uacgaguacg uggagugccc caucagaggc accgccgccg agaacaagga gaaccuggac      240

cccagcaacc ugaugccccc ccccaaccag acccccgccc ccgaccagcc cuucgcccug      300

agcaccguga gagaggagag cagcaucccc agagccgaca gcgagaagaa guggguguac      360

cccagcgagc agauguucug gaacgccaug cugaagaagg gcuggaagug gaaggacgag      420

gacaucagcc agaaggacau guacaacauc aucagaaucc acaaccagaa caacgagcag      480

gccuggaagg agauccugaa gugggaggcc cugcacgccg ccgagugccc cugcggcccc      540

agccugauca gauucggcgg caaggccaag gaguacagcc ccagagccag aaucagaagc      600

uggaugggcu acgagcugcc cuucgacaga cacgacugga ucaucaacag augcggcacc      660

gaggugagau acgugaucga cuacuacgac ggcggcgagg ugaacaagga cuaccaguuc      720

accauccugg acgugagacc cgcccuggac agccugagcg ccguguggga cagaaugaag      780

guggccuggu ggagauggac cagcuga                                          807


<210>  7183
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7183
augggccuga gccccuccgc cccugcugug gccguccagg cgucuaacgc uagcgccucc       60

ccgcccucug ggugcccuau gcacgaggga aagaugaaag gcugucccgu uaauaccgaa      120

ccuagcgggc ccacaugcga gaagaaaacg uacuccgugc cugcccauca agaaagagcu      180

uaugaguacg uggaaugucc gauccgggga accgccgcug agaacaagga gaaucucgac      240

cccucuaacc ugaugccucc cccuaaucag acacccgccc cggaucagcc uuucgcgcuu      300

agcaccgucc gcgaagaguc cagcauuccc agagccgacu cugagaaaaa guggguguau      360

ccuuccgaac agauguuuug gaacgcuaug cugaagaaag gcuggaagug gaaagaugag      420

gacaucagcc aaaaggauau guacaauauu auccggauuc acaaccagaa uaacgaacag      480

gccuggaaag agauccucaa gugggaagcu cugcaugccg cggagugccc cugugggccc      540

ucucuuaucc gcuucggagg caaggccaaa gaauauuccc cuagagcucg gauucgcagc      600

uggaugggcu acgagcugcc guuugacaga cacgauugga ucauuaaucg gugcgggaca      660

gagguucgcu augugaucga cuacuacgau ggaggcgaag ucaacaagga cuaucaguuc      720

accauucucg augugagacc cgcccuggac ucucuguccg cuguuuggga ucggaugaaa      780

guggccuggu ggcgcuggac aagcuga                                          807


<210>  7184
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__EAW98784

<400>  7184
augggacuaa guccaagcgc accagcagua gcaguacaag caaguaacgc aagcgcauca       60

ccgccaucag gauguccaau gcacgaagga aaaaugaaag gauguccagu aaacacagaa      120

ccaagcggac caacaugcga aaaaaaaaca uauagcgugc cagcacacca agaaagagca      180

uaugaauaug uagaaugccc aauaagagga acagcagcag aaaauaaaga aaauuuagac      240

ccaagcaauc uaaugccccc accaaaucaa acaccagcac cagaucaacc auucgcauua      300

ucaacaguaa gagaagaauc aaguauacca agagcagaca gcgaaaaaaa auggguauac      360

ccaagugaac aaauguuuug gaacgcaaug cuaaaaaaag gauggaaaug gaaagaugaa      420

gauauaucac aaaaagacau guacaauaua auaagaauac acaaucaaaa uaaugaacaa      480

gcauggaagg aaauacuaaa augggaagca cuacacgcag cagaaugccc augcggacca      540

aguuuaauaa gauuuggagg aaaagcaaaa gaauacagcc caagagcaag aauaagaagc      600

uggaugggau acgaacuacc auuugauaga caugacugga uaauaaacag augcggaaca      660

gaaguaagau acguaauaga uuacuaugac ggaggagaag uaaauaaaga uuaccaauuu      720

acaauacuag auguaagacc agcauuagac ucacuaucag caguauggga uagaaugaaa      780

guagcauggu ggagauggac aaguuaa                                          807


<210>  7185
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__B8XYC5

<400>  7185

Met Phe Ala Pro Ala Val Met Arg Ala Phe Arg Lys Asn Lys Thr Leu 
1               5                   10                  15      


Gly Tyr Gly Val Pro Met Leu Leu Leu Ile Val Gly Gly Ser Phe Gly 
            20                  25                  30          


Leu Arg Glu Phe Ser Gln Ile Arg Tyr Asp Ala Val Lys Ser Lys Met 
        35                  40                  45              


Asp Pro Glu Leu Glu Lys Lys Leu Lys Glu Asn Lys Ile Ser Leu Glu 
    50                  55                  60                  


Ser Glu Tyr Glu Lys Ile Lys Asp Ser Lys Phe Asp Asp Trp Lys Asn 
65                  70                  75                  80  


Ile Arg Gly Pro Arg Pro Trp Glu Asp Pro Asp Leu Leu Gln Gly Arg 
                85                  90                  95      


Asn Pro Glu Ser Leu Lys Thr Lys Thr Thr 
            100                 105     


<210>  7186
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7186
auguuugcac ccgcggugau gcgugcuuuu cgcaagaaca agacucucgg cuauggaguc       60

cccauguugu ugcugauugu uggagguucu uuuggucuuc gugaguuuuc ucaaauccga      120

uaugaugcug ugaagaguaa aauggauccu gagcuugaaa aaaaacugaa agagaauaaa      180

auaucuuuag agucggaaua ugagaaaauc aaagacucca aguuugauga cuggaagaau      240

auucgaggac ccaggccuug ggaagauccu gaccuccucc aaggaagaaa uccagaaagc      300

cuuaagacua agacaacuug a                                                321


<210>  7187
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7187
auguucgccc ccgccgugau gcgcgcguuc cggaagaaca agacccuggg cuacggggug       60

ccgaugcucc ugcugaucgu gggcgggagc uucggccucc gcgaguucuc ccagauccgg      120

uacgacgccg ucaagagcaa gauggacccc gagcuggaga agaagcugaa ggagaacaag      180

aucucccucg agagcgagua cgagaagauc aaggacucca aguucgacga cuggaagaac      240

auccgcgggc cccggcccug ggaggacccg gaccugcugc agggccgcaa ccccgagagc      300

cucaagacca agacgaccug a                                                321


<210>  7188
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7188
auguucgccc ccgccgucau gcgcgccuuc cgcaagaaca agacccucgg cuacggcguc       60

cccaugcucc uccucaucgu cggcggcucc uucggccucc gcgaguucuc ccagauccgc      120

uacgacgccg ucaaguccaa gauggacccc gagcucgaga agaagcucaa ggagaacaag      180

aucucccucg aguccgagua cgagaagauc aaggacucca aguucgacga cuggaagaac      240

auccgcggcc cccgccccug ggaggacccc gaccuccucc agggccgcaa ccccgagucc      300

cucaagacca agaccaccug a                                                321


<210>  7189
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7189
auguucgccc ccgcugugau gagagcauuu aggaagaaca aaacccuggg cuacgggguc       60

ccuaugcucc uucugaucgu uggagguagc uucggcuugc gggaguuuuc ccagauucgc      120

uaugacgccg ugaagucuaa aauggaucca gaauuagaga agaaacugaa ggaaaauaag      180

auaucacuag agagugaaua cgagaaaauc aaggacagca aauucgauga cuggaagaac      240

auucgagggc cgcgucccug ggaggauccu gaccuccugc aaggaagaaa uccagaaucc      300

cuuaaaacaa agacuacgug a                                                321


<210>  7190
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7190
auguucgccc ccgccgugau gagagccuuc agaaagaaca agacccuggg cuacggcgug       60

cccaugcugc ugcugaucgu gggcggcagc uucggccuga gagaguucag ccagaucaga      120

uacgacgccg ugaagagcaa gauggacccc gagcuggaga agaagcugaa ggagaacaag      180

aucagccugg agagcgagua cgagaagauc aaggacagca aguucgacga cuggaagaac      240

aucagaggcc ccagacccug ggaggacccc gaccugcugc agggcagaaa ccccgagagc      300

cugaagacca agaccaccug a                                                321


<210>  7191
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7191
auguucgccc ccgcugugau gagagccuuu cggaagaaca aaacccuggg cuacgggguc       60

ccuaugcucc ugcuuaucgu uggaggcagc uucgggcugc gcgaguuuuc ccagauuaga      120

uaugacgcgg ugaagucuaa aauggauccg gaacucgaga agaaacugaa ggaaaauaag      180

aucagccuug aguccgaaua cgagaaaauu aaggacucua aauucgauga cuggaagaac      240

auccggggac cccgcccuug ggaggauccc gaccugcucc aaggcagaaa uccugaaagc      300

cugaaaacaa agacgaccug a                                                321


<210>  7192
<211>  321
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__ACJ76681

<400>  7192
auguucgcac cagcaguaau gagagcauuc agaaaaaaca aaacacuagg auacggagua       60

ccaaugcuac uauuaauagu aggaggaagc uucggacuaa gagaauucuc acaaauaaga      120

uacgacgcag uaaaaagcaa aauggaccca gaacuagaaa aaaaacuaaa agaaaacaaa      180

auaagccuag aaucagaaua cgaaaaaaua aaagacucaa aauucgacga cuggaaaaac      240

auaagaggac caagaccaug ggaagaccca gaccuacuac aaggaagaaa cccagaaagc      300

cuaaaaacaa aaacaacaua a                                                321


<210>  7193
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__G4XXL9

<400>  7193

Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser 
1               5                   10                  15      


Gln Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn 
            20                  25                  30          


Leu His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser 
        35                  40                  45              


Tyr Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr 
    50                  55                  60                  


Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys 
65                  70                  75                  80  


Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile 
                85                  90                  95      


Ala Tyr Leu Lys Lys Ala Thr Asn Glu 
            100                 105 


<210>  7194
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AEP27189

<400>  7194
augggugaug uugagaaagg caagaagauu uuuauuauga aguguuccca gugccacacc       60

guugaaaagg gaggcaagca caagacuggg ccaaaucucc auggucucuu ugggcggaag      120

acaggucagg ccccuggaua cucuuacaca gccgccaaua agaacaaagg caucaucugg      180

ggagaggaua cacugaugga guauuuggag aaucccaaga aguacauccc uggaacaaaa      240

augaucuuug ucggcauuaa gaagaaggaa gaaagggcag acuuaauagc uuaucucaaa      300

aaagcuacua augaguaa                                                    318


<210>  7195
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7195
augggcgacg uggagaaggg gaagaagauc uucaucauga agugcagcca gugccacacc       60

gucgagaagg gcgggaagca caagaccggc cccaaccugc acggccucuu cgggcgcaag      120

acgggccagg ccccggggua cuccuacacc gccgcgaaca agaacaaggg caucaucugg      180

ggcgaggaca cccugaugga guaccuggag aaccccaaga aguacauccc cgggaccaag      240

augaucuucg uggggaucaa gaagaaggag gagcgggccg accucaucgc cuaccugaag      300

aaggccacga acgaguga                                                    318


<210>  7196
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7196
augggcgacg ucgagaaggg caagaagauc uucaucauga agugcuccca gugccacacc       60

gucgagaagg gcggcaagca caagaccggc cccaaccucc acggccucuu cggccgcaag      120

accggccagg cccccggcua cuccuacacc gccgccaaca agaacaaggg caucaucugg      180

ggcgaggaca cccucaugga guaccucgag aaccccaaga aguacauccc cggcaccaag      240

augaucuucg ucggcaucaa gaagaaggag gagcgcgccg accucaucgc cuaccucaag      300

aaggccacca acgaguga                                                    318


<210>  7197
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7197
augggcgacg uggagaaggg gaaaaagauc uucauuauga aaugcagcca gugucacacc       60

gucgaaaagg gagguaaaca uaagacaggc cccaaccugc acgggcucuu uggaagaaag      120

acuggccaag ccccugguua cuccuauacg gcugcaaaua aaaacaaggg gauaaucugg      180

ggagaggaua cccuuaugga auaccuggag aauccgaaaa aguauauucc aggcacaaaa      240

augaucuucg uuggcauuaa gaagaaagaa gagagggccg acuugaucgc guacuuaaag      300

aaagcuacua acgaguga                                                    318


<210>  7198
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7198
augggcgacg uggagaaggg caagaagauc uucaucauga agugcagcca gugccacacc       60

guggagaagg gcggcaagca caagaccggc cccaaccugc acggccuguu cggcagaaag      120

accggccagg cccccggcua cagcuacacc gccgccaaca agaacaaggg caucaucugg      180

ggcgaggaca cccugaugga guaccuggag aaccccaaga aguacauccc cggcaccaag      240

augaucuucg ugggcaucaa gaagaaggag gagagagccg accugaucgc cuaccugaag      300

aaggccacca acgaguga                                                    318


<210>  7199
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7199
augggcgacg uggagaaggg gaaaaagauc uucauuauga aaugcagcca gugucacacc       60

gucgaaaagg gaggcaaaca uaagacaggg cccaaccugc acggacucuu uggcagaaag      120

acggggcaag ccccuggaua cuccuauacc gcugccaaua aaaacaaggg caucauuugg      180

ggcgaggaua cacugaugga auaccuugag aauccgaaaa aguauauccc cgggaccaaa      240

augauuuucg uuggaaucaa gaagaaagag gaacgggcgg accugaucgc uuaccucaag      300

aaagccacaa acgaguga                                                    318


<210>  7200
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AEP27189

<400>  7200
augggagacg uagaaaaagg aaaaaaaaua uucauaauga aaugcagcca augccacaca       60

guagaaaaag gaggaaaaca caaaacagga ccaaaccuac acggacuauu cggaagaaaa      120

acaggacaag caccaggaua cagcuacaca gcagcaaaca aaaacaaagg aauaauaugg      180

ggagaagaca cacuaaugga auaccuagaa aacccaaaaa aauacauacc aggaacaaaa      240

augauauucg uaggaauaaa aaaaaaagaa gaaagagcag accuaauagc auaccuaaaa      300

aaagcaacaa acgaauaa                                                    318


<210>  7201
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__H0UI06

<400>  7201

Met His Thr Gln Asp Ser Glu Val Val Pro Val Pro Ala Trp Pro Phe 
1               5                   10                  15      


Ser Leu Val Val Phe Ser Cys Gly Gly Cys Trp Ser Val Thr Ala Lys 
            20                  25                  30          


Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
        35                  40                  45              


Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
    50                  55                  60                  


Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
65                  70                  75                  80  


Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
            100                 105                 110         


Lys Gln Glu 
        115 


<210>  7202
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__CCF23109

<400>  7202
augcauacgc aagacucgga gguaguuccg guuccggcgu ggccauuuuc guugguggug       60

uucaguugug gcgguugcug gucaguaaca gccaagaugc ugcggaaucu gcuggcucuu      120

cgucagauug ggcagaggac gauaagcacu gcuucccgca ggcauuuuaa aaauaaaguu      180

ccggagaagc aaaaacuguu ccaggaggau gaugaaauuc cacuguaucu aaaggguggg      240

guagcugaug cccuccugua uagagccacc augauucuua caguuggugg aacagcauau      300

gccauauaug agcuggcugu ggcuucauuu cccaagaagc aggaguga                   348


<210>  7203
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7203
augcacaccc aggacagcga gguggugccc gugccggccu ggcccuucuc ccuggugguc       60

uucagcugcg gcgggugcug guccgugacc gccaagaugc uccgcaaccu gcuggcgcuc      120

cggcagaucg gccagcgcac gaucagcacc gccucccggc gccacuucaa gaacaaggug      180

cccgagaagc agaagcuguu ccaggaggac gacgagaucc cccuguaccu caagggcggg      240

gucgccgacg cccugcugua ccgggccacc augauccuca ccgucggggg cacggcguac      300

gccaucuacg agcuggccgu ggccagcuuc ccgaagaagc aggaguga                   348


<210>  7204
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7204
augcacaccc aggacuccga ggucgucccc guccccgccu ggcccuucuc ccucgucguc       60

uucuccugcg gcggcugcug guccgucacc gccaagaugc uccgcaaccu ccucgcccuc      120

cgccagaucg gccagcgcac caucuccacc gccucccgcc gccacuucaa gaacaagguc      180

cccgagaagc agaagcucuu ccaggaggac gacgagaucc cccucuaccu caagggcggc      240

gucgccgacg cccuccucua ccgcgccacc augauccuca ccgucggcgg caccgccuac      300

gccaucuacg agcucgccgu cgccuccuuc cccaagaagc aggaguga                   348


<210>  7205
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7205
augcacaccc aggacagcga gguggucccc guuccugccu ggccauucuc ccugguggua       60

uuuucuugcg gcggguguug gucagugaca gcuaagaugc ucagaaaccu ucuggcauug      120

aggcaaaucg gacagcggac uauuaguacg gccagccgcc gacauuucaa aaauaagguc      180

ccggaaaaac agaaguuauu ucaggaggau gacgaaauac cccuguaccu aaaagguggc      240

guggcggaug cucuccugua ucgugccacc augauccuua caguuggggg aacugcauac      300

gccauuuaug agcuggcugu ggcauccuuc ccuaagaagc aagaauga                   348


<210>  7206
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7206
augcacaccc aggacagcga gguggugccc gugcccgccu ggcccuucag ccugguggug       60

uucagcugcg gcggcugcug gagcgugacc gccaagaugc ugagaaaccu gcuggcccug      120

agacagaucg gccagagaac caucagcacc gccagcagaa gacacuucaa gaacaaggug      180

cccgagaagc agaagcuguu ccaggaggac gacgagaucc cccuguaccu gaagggcggc      240

guggccgacg cccugcugua cagagccacc augauccuga ccgugggcgg caccgccuac      300

gccaucuacg agcuggccgu ggccagcuuc cccaagaagc aggaguga                   348


<210>  7207
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7207
augcacaccc aggacagcga gguggucccc guuccugccu ggccguucuc ccugguggug       60

uuuucuugcg gcggguguug gagcgucaca gcuaagaugc ucagaaaccu gcuugcccug      120

cggcaaaucg gacagcgcac gauuuccacc gcgucuagac ggcauuucaa aaauaaggug      180

cccgaaaaac agaagcucuu ucaggaggau gacgaaaucc cucuguaccu uaaaggcggg      240

guugcugaug cccugcucua ucgcgccaca augauucuga ccgugggagg cacagcuuac      300

gccaucuaug agcuggcugu cgccagcuuc cccaagaagc aagaauga                   348


<210>  7208
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__CCF23109

<400>  7208
augcacacac aagauagcga aguaguacca guaccagcau ggccauucuc acuaguaguc       60

uuuagcugug gaggaugcug gaguguaaca gcaaaaaugc uaagaaacuu auuagcacua      120

agacaaauag gacaaagaac aauaucaaca gcaagcagaa gacauuucaa aaacaaagua      180

ccagaaaaac aaaaacuauu ucaagaagac gaugaaauac cauuauaccu aaaaggagga      240

guagcagaug cauuacuaua uagagcaaca augauauuaa caguaggagg aacagcauac      300

gcaauauaug aacuagcagu agcaucauuc ccaaaaaaac aagaauaa                   348


<210>  7209
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__H6SG12

<400>  7209

Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser 
1               5                   10                  15      


Thr Ala Arg Asn Arg Phe Gln Asn Arg Val Arg Glu Lys Gln Leu Phe 
            20                  25                  30          


Gln Glu Asp Asn Asp Ile Pro Leu Tyr Leu Lys Gly Gly Ile Val Asp 
        35                  40                  45              


Asn Ile Leu Tyr Arg Val Thr Met Thr Leu Cys Leu Gly Gly Thr Val 
    50                  55                  60                  


Tyr Ser Leu Tyr Ser Leu Gly Trp Ala Ser Phe Pro Arg Asn 
65                  70                  75              


<210>  7210
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__CCF23103

<400>  7210
augcaggccc uucggguguc ccaggcgcug auccgcuccu ucagcuccac cgcccggaac       60

cgcuuucaga accgagugcg cgagaaacag cucuuccagg aggacaauga caucccguug      120

uaccugaagg gcggcaucgu ugacaacauc cuguaccgag ugacaaugac gcugugucug      180

ggcggcacug ucuacagcuu guacucccuu ggcugggccu ccuuccccag gaauuaa         237


<210>  7211
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7211
augcaggccc ugcgcgugag ccaggcccuc auccgguccu ucagcuccac cgcgcgcaac       60

cgguuccaga accgcguccg ggagaagcag cuguuccagg aggacaacga caucccccug      120

uaccucaagg gcgggaucgu ggacaacauc cuguaccgcg ugaccaugac gcugugccuc      180

ggcgggaccg ucuacagccu guacucccug ggcugggcca gcuucccgcg gaacuga         237


<210>  7212
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7212
augcaggccc uccgcgucuc ccaggcccuc auccgcuccu ucuccuccac cgcccgcaac       60

cgcuuccaga accgcguccg cgagaagcag cucuuccagg aggacaacga caucccccuc      120

uaccucaagg gcggcaucgu cgacaacauc cucuaccgcg ucaccaugac ccucugccuc      180

ggcggcaccg ucuacucccu cuacucccuc ggcugggccu ccuucccccg caacuga         237


<210>  7213
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7213
augcaggccc ugagagugag ccaagcucuc aucagguccu ucucuucaac cgcacggaac       60

cgcuuucaga aucgaguccg ugagaagcag cuuuuccagg aagacaacga uauuccccug      120

uacuugaaag gcgggauagu ugacaauauc uuauauagag ugacaaugac ucugugccua      180

ggagguacgg uauacagucu cuauagccug ggcugggccu ccuuuccuag gaacuga         237


<210>  7214
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7214
augcaggccc ugagagugag ccaggcccug aucagaagcu ucagcagcac cgccagaaac       60

agauuccaga acagagugag agagaagcag cuguuccagg aggacaacga caucccccug      120

uaccugaagg gcggcaucgu ggacaacauc cuguacagag ugaccaugac ccugugccug      180

ggcggcaccg uguacagccu guacagccug ggcugggcca gcuuccccag aaacuga         237


<210>  7215
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7215
augcaggccc ugagagugag ccaagcucuc auccgguccu ucucuagcac cgcccgcaac       60

agauuucaga aucggguccg cgagaagcag cuguuccagg aagacaacga uauuccccuu      120

uaccugaaag gcgggaucgu ugacaauauu cucuauagag ugacaaugac gcugugccuu      180

ggaggcaccg uguacucccu guauucucuc gggugggcga gcuuuccucg gaacuga         237


<210>  7216
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__CCF23103

<400>  7216
augcaagcau uaagaguaag ccaagcauua auaagaagcu uuagcucaac agcaagaaau       60

agauuucaaa auagaguaag agaaaaacaa cuauuucaag aagacaauga cauaccauua      120

uacuuaaaag gaggaauagu agauaacaua cuauauagag uaacaaugac auuaugcuua      180

ggaggaacag uauacucacu auauagcuua ggaugggcau cauucccaag aaauuaa         237


<210>  7217
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__H6SG13

<400>  7217

Met Ala Leu Pro Leu Arg Pro Leu Thr Arg Gly Val Ala Ser Ala Ala 
1               5                   10                  15      


Lys Gly Gly His Gly Gly Ala Gly Ala Arg Thr Trp Arg Leu Leu Thr 
            20                  25                  30          


Phe Val Leu Ala Leu Pro Ser Val Ala Leu Cys Thr Phe Asn Ser Tyr 
        35                  40                  45              


Leu His Ser Gly His Arg Pro Arg Pro Glu Phe Arg Pro Tyr Gln His 
    50                  55                  60                  


Leu Arg Ile Arg Thr Lys Pro Tyr Pro Trp Gly Asp Gly Asn His Thr 
65                  70                  75                  80  


Leu Phe His Asn Ser His Val Asn Pro Leu Pro Thr Gly Tyr Glu His 
                85                  90                  95      


Pro 
    


<210>  7218
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__CCF23106

<400>  7218
auggcuuugc cucugaggcc ccugacccgg ggcguggcca gcgcugccaa aggaggccac       60

ggaggagcag gagcucguac cuggcgucug cugaccuucg ugcuggcgcu gcccagcgug      120

gcccucugca ccuucaacuc cuaucuccac ucgggccacc gcccgcgccc cgaguuccgu      180

cccuaccaac accuccgcau ccgcaccaag cccuaccccu ggggggacgg caaccacacu      240

cuguuccaca auagccacgu gaacccucug cccacgggcu acgaacaccc cuga            294


<210>  7219
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7219
auggcccugc cccuccgccc gcugacccgg ggcguggcca gcgcggccaa gggcgggcac       60

gggggcgccg gggcccgcac cuggcggcug cucacguucg uccuggcccu gcccuccgug      120

gcgcucugca ccuucaacag cuaccugcac uccggccacc gcccccggcc cgaguuccgc      180

ccguaccagc accuccggau ccgcaccaag cccuaccccu ggggcgacgg gaaccacacc      240

cuguuccaca acagccacgu gaacccccug ccgacgggcu acgagcaccc cuga            294


<210>  7220
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7220
auggcccucc cccuccgccc ccucacccgc ggcgucgccu ccgccgccaa gggcggccac       60

ggcggcgccg gcgcccgcac cuggcgccuc cucaccuucg uccucgcccu ccccuccguc      120

gcccucugca ccuucaacuc cuaccuccac uccggccacc gcccccgccc cgaguuccgc      180

cccuaccagc accuccgcau ccgcaccaag cccuaccccu ggggcgacgg caaccacacc      240

cucuuccaca acucccacgu caacccccuc cccaccggcu acgagcaccc cuga            294


<210>  7221
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7221
auggcccugc cccucagacc ucuuaccagg ggcguggcua gcgcagccaa agggggacac       60

gguggcgcgg gggcucggac auggcgccug uugacuuucg ucuuagcccu gccauccguu      120

gcacuaugca cguuuaacuc uuaccuccau ucaggacacc gaccgcgucc cgaguucaga      180

ccuuaucagc aucugaggau ccggaccaag ccauaccccu ggggcgacgg uaaucacaca      240

cuuuuucaua acagucacgu gaauccucug ccaacugggu augaacaccc cuga            294


<210>  7222
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7222
auggcccugc cccugagacc ccugaccaga ggcguggcca gcgccgccaa gggcggccac       60

ggcggcgccg gcgccagaac cuggagacug cugaccuucg ugcuggcccu gcccagcgug      120

gcccugugca ccuucaacag cuaccugcac agcggccaca gacccagacc cgaguucaga      180

cccuaccagc accugagaau cagaaccaag cccuaccccu ggggcgacgg caaccacacc      240

cuguuccaca acagccacgu gaacccccug cccaccggcu acgagcaccc cuga            294


<210>  7223
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7223
auggcccugc cccucagacc ucugacccgg ggcguggcua gcgccgcgaa agggggacac       60

ggcggggcug gagcccgcac auggagacuu cugacguucg uccucgcccu gccguccguu      120

gcucuuugca ccuuuaacuc uuaccugcau agcggccacc ggccccgccc ugaguucaga      180

cccuaucagc aucuccggau ccgcacaaag ccuuaccccu ggggagacgg gaaucacacc      240

cuguuucaua acucccacgu gaauccucug ccgacaggcu augaacaccc cuga            294


<210>  7224
<211>  294
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__CCF23106

<400>  7224
auggcacuac cacuaagacc auuaacaaga ggaguagcau cagcagcaaa aggaggacac       60

ggaggagcag gagcaagaac auggagacua cuaacauucg uacuagcacu accaucagua      120

gcacuaugca cauucaacuc auaccuacac ucaggacaca gaccaagacc agaauucaga      180

ccauaccaac accuaagaau aagaacaaaa ccauacccau ggggagacgg aaaccacaca      240

cuauuccaca acucacacgu aaacccacua ccaacaggau acgaacaccc auaa            294


<210>  7225
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__H6SG14

<400>  7225

Met Leu Pro Arg Ala Ala Trp Ser Leu Val Leu Arg Lys Gly Gly Gly 
1               5                   10                  15      


Gly Arg Arg Gly Met His Ser Ser Glu Gly Thr Thr Arg Gly Gly Gly 
            20                  25                  30          


Lys Met Ser Pro Tyr Thr Asn Cys Tyr Ala Gln Arg Tyr Tyr Pro Met 
        35                  40                  45              


Pro Glu Glu Pro Phe Cys Thr Glu Leu Asn Ala Glu Glu Gln Ala Leu 
    50                  55                  60                  


Lys Glu Lys Glu Lys Gly Ser Trp Thr Gln Leu Thr His Ala Glu Lys 
65                  70                  75                  80  


Val Ala Leu Tyr Arg Leu Gln Phe Asn Glu Thr Phe Ala Glu Met Asn 
                85                  90                  95      


Arg Arg Ser Asn Glu Trp Lys Thr Val Met Gly Cys Val Phe Phe Phe 
            100                 105                 110         


Ile Gly Phe Ala Ala Leu Val Ile Trp Trp Gln Arg Val Tyr Val Phe 
        115                 120                 125             


Pro Pro Lys Pro Ile Thr Leu Thr Asp Glu Arg Lys Ala Gln Gln Leu 
    130                 135                 140                 


Gln Arg Met Leu Asp Met Lys Val Asn Pro Val Gln Gly Leu Ala Ser 
145                 150                 155                 160 


Arg Trp Asp Tyr Glu Lys Lys Gln Trp Lys Lys 
                165                 170     


<210>  7226
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__CCF23107

<400>  7226
augcucccca gagcugccug gagcuuggug cugaggaaag guggaggugg aagacgaggg       60

augcacagcu cagaaggcac cacccguggu ggggggaaga ugucccccua caccaacugc      120

uaugcccagc gcuacuaccc caugccagaa gagcccuucu gcacagaacu caacgcugag      180

gagcaggccc ugaaggagaa ggagaaggga agcuggaccc agcugaccca cgccgaaaag      240

guggccuugu accggcucca guucaaugag accuuugcgg agaugaaccg ucgcuccaau      300

gaguggaaga cagugauggg uugugucuuc uucuucauug gauucgcagc ucuggugauu      360

ugguggcagc gggucuacgu auuuccucca aagccgauca ccuugacgga cgagcggaaa      420

gcccagcagc ugcagcgcau gcuggacaug aaggugaauc cugugcaggg ccuggccucc      480

cgcugggacu augagaagaa gcaguggaag aaguga                                516


<210>  7227
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7227
augcugcccc gcgccgccug gagccucgug cugcggaagg gcgggggcgg gcgccggggc       60

augcacucca gcgaggggac cacccgcggc ggcgggaaga uguccccgua cacgaacugc      120

uacgcgcagc gguacuaccc caugcccgag gagcccuucu gcaccgagcu gaacgccgag      180

gagcaggccc ucaaggagaa ggagaagggc agcuggaccc agcugaccca cgccgagaag      240

gucgcccugu accgccucca guucaacgag acguucgcgg agaugaaccg gcgcuccaac      300

gaguggaaga ccgugauggg gugcguguuc uucuucaucg gcuucgccgc ccuggucauc      360

ugguggcagc ggguguacgu guucccgccc aagcccauca cccugaccga cgagcgcaag      420

gcccagcagc uccagcggau gcuggacaug aaggucaacc ccgugcaggg gcuggcgagc      480

cgcugggacu acgagaagaa gcaguggaag aaguga                                516


<210>  7228
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7228
augcuccccc gcgccgccug gucccucguc cuccgcaagg gcggcggcgg ccgccgcggc       60

augcacuccu ccgagggcac cacccgcggc ggcggcaaga ugucccccua caccaacugc      120

uacgcccagc gcuacuaccc caugcccgag gagcccuucu gcaccgagcu caacgccgag      180

gagcaggccc ucaaggagaa ggagaagggc uccuggaccc agcucaccca cgccgagaag      240

gucgcccucu accgccucca guucaacgag accuucgccg agaugaaccg ccgcuccaac      300

gaguggaaga ccgucauggg cugcgucuuc uucuucaucg gcuucgccgc ccucgucauc      360

ugguggcagc gcgucuacgu cuuccccccc aagcccauca cccucaccga cgagcgcaag      420

gcccagcagc uccagcgcau gcucgacaug aaggucaacc ccguccaggg ccucgccucc      480

cgcugggacu acgagaagaa gcaguggaag aaguga                                516


<210>  7229
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7229
augcugccca gagccgcuug gagccucgug cuuaggaagg gcgggggagg ucggcgcggc       60

augcacuccu cugaggggac cacacgagga ggcgguaaaa ugucaccuua cacuaacugc      120

uaugcacagc guuacuaucc aaugccggaa gaacccuucu guacggaacu gaaugccgag      180

gaacaagcgu ugaaggagaa agagaagggg aguuggaccc aguuaacaca ugcugaaaaa      240

gucgcccugu acagacuaca guuuaacgag acuuucgcag aaaugaauag gcggagcaac      300

gaguggaaga ccguuauggg augcguguuu uucuuuaucg gcuucgccgc ucucguaauu      360

ugguggcagc gcguguaugu cuuuccucca aagcccauaa cacugaccga cgagagaaaa      420

gcacaacagc uucagaggau gcuggauaug aaggugaauc cuguucaggg cuuggccucc      480

cggugggacu acgagaaaaa gcaauggaaa aaguga                                516


<210>  7230
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7230
augcugccca gagccgccug gagccuggug cugagaaagg gcggcggcgg cagaagaggc       60

augcacagca gcgagggcac caccagaggc ggcggcaaga ugagccccua caccaacugc      120

uacgcccaga gauacuaccc caugcccgag gagcccuucu gcaccgagcu gaacgccgag      180

gagcaggccc ugaaggagaa ggagaagggc agcuggaccc agcugaccca cgccgagaag      240

guggcccugu acagacugca guucaacgag accuucgccg agaugaacag aagaagcaac      300

gaguggaaga ccgugauggg cugcguguuc uucuucaucg gcuucgccgc ccuggugauc      360

ugguggcaga gaguguacgu guuccccccc aagcccauca cccugaccga cgagagaaag      420

gcccagcagc ugcagagaau gcuggacaug aaggugaacc ccgugcaggg ccuggccagc      480

agaugggacu acgagaagaa gcaguggaag aaguga                                516


<210>  7231
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7231
augcugccca gagccgcuug gagccucgug cugcggaagg gcgggggagg ccgcagaggg       60

augcacuccu cugagggaac cacacggggc gggggaaaaa ugagcccuua cacgaacugc      120

uaugcccagc gcuacuaucc gaugcccgaa gaaccuuucu guaccgaacu uaaugcggag      180

gaacaagcuc ugaaggagaa agagaagggc uccuggacac agcucaccca ugccgaaaaa      240

gucgcccugu acagacuuca guuuaacgag acauucgcug aaaugaaucg gcgcucuaac      300

gaguggaaga ccguuauggg cugcguguuu uucuuuaucg gguucgccgc ucuggugauu      360

ugguggcaga gagucuaugu guuucccccu aagcccauca cacucaccga cgagcggaaa      420

gcccaacagc ugcagcgcau gcuggauaug aagguuaauc cugugcaggg acucgcgagc      480

agaugggacu acgagaaaaa gcaauggaaa aaguga                                516


<210>  7232
<211>  516
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__CCF23107

<400>  7232
augcuaccga gagcagcaug gagccuagua uuaagaaaag gagguggagg aagaagagga       60

augcacucaa gcgaaggaac aacaagagga ggaggaaaaa ugucaccaua uacaaauugc      120

uaugcacaaa gauauuaccc aaugccagaa gaaccauucu gcacggaauu aaacgcagaa      180

gaacaagcac uaaaagaaaa agaaaaagga ucauggacac aauuaacaca ugcagaaaaa      240

guagcauuau acagacuaca auucaaugaa acauucgcag aaaugaacag aagaucaaac      300

gaauggaaaa caguaauggg augcguauuc uuuuucauag guuuugcagc acuaguaaua      360

ugguggcaaa gaguauacgu auucccacca aaaccaauaa cauuaacaga ugaaagaaaa      420

gcacaacaac uacaaagaau guuagauaug aaagucaauc caguacaagg acuagcaagc      480

agaugggauu acgaaaaaaa acaauggaaa aaauaa                                516


<210>  7233
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__H6SG15

<400>  7233

Met Ala Val Val Gly Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser 
1               5                   10                  15      


Arg Pro Gln Leu Gly Arg Pro Met Ser Ser Gly Ala His Gly Glu Glu 
            20                  25                  30          


Gly Ser Ala Arg Met Trp Lys Thr Leu Thr Phe Phe Val Ala Leu Pro 
        35                  40                  45              


Gly Val Ala Val Ser Met Leu Asn Val Tyr Leu Lys Ser His His Gly 
    50                  55                  60                  


Glu His Glu Arg Pro Glu Phe Ile Ala Tyr Pro His Leu Arg Ile Arg 
65                  70                  75                  80  


Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe His Asn 
                85                  90                  95      


Pro His Val Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
            100                 105                 


<210>  7234
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__CCF23108

<400>  7234
auggcgguag uugguguguc cucgguuucu cggcugcugg gucggucccg cccacagcug       60

gggcggccua ugucgagugg cgcccauggc gaagagggcu cagcucgcau guggaagacu      120

cucaccuucu ucgucgcgcu ccccggggug gcagucagca ugcugaaugu guaccugaag      180

ucgcaccacg gagagcacga gagacccgag uucaucgccu acccccaucu ccgcaucagg      240

accaagccgu uucccugggg agaugguaac cauacucuau uccauaaccc ucaugugaau      300

ccacuuccaa cuggcuacga agaugaauaa                                       330


<210>  7235
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7235
auggccgugg ucggcgugag cagcgugagc cgccugcucg ggcggucccg cccccagcug       60

ggccggccga ugagcuccgg ggcccacggc gaggagggga gcgcgcgcau guggaagacc      120

cugaccuucu ucgucgcccu ccccggcgug gccgugucca ugcugaacgu cuaccugaag      180

ucccaccacg gcgagcacga gcggcccgag uucaucgccu acccccaccu ccgcauccgg      240

acgaagccgu uccccugggg cgacgggaac cacacccugu uccacaaccc ccacgugaac      300

ccccugccga ccggguacga ggacgaguga                                       330


<210>  7236
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7236
auggccgucg ucggcgucuc cuccgucucc cgccuccucg gccgcucccg cccccagcuc       60

ggccgcccca uguccuccgg cgcccacggc gaggagggcu ccgcccgcau guggaagacc      120

cucaccuucu ucgucgcccu ccccggcguc gccgucucca ugcucaacgu cuaccucaag      180

ucccaccacg gcgagcacga gcgccccgag uucaucgccu acccccaccu ccgcauccgc      240

accaagcccu uccccugggg cgacggcaac cacacccucu uccacaaccc ccacgucaac      300

ccccucccca ccggcuacga ggacgaguga                                       330


<210>  7237
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7237
auggccgugg ucggcguuag cuccgugucu agacugcucg ggaggucacg gccccagcuu       60

ggacgcccua ugaguagcgg ugcucacggc gaggaagggu ccgcacgaau guggaagacc      120

cugacauucu uuguagccuu gccaggagug gcggucucua uguuaaacgu guaccugaaa      180

ucgcaucacg gcgagcauga acguccggag uucaucgcuu auccccaccu aagaauuagg      240

acuaagccuu uuccaugggg ugacgggaau cauacccucu uccacaaccc ccacguuaau      300

ccucugccaa cgggauacga agaugaguga                                       330


<210>  7238
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7238
auggccgugg ugggcgugag cagcgugagc agacugcugg gcagaagcag accccagcug       60

ggcagaccca ugagcagcgg cgcccacggc gaggagggca gcgccagaau guggaagacc      120

cugaccuucu ucguggcccu gcccggcgug gccgugagca ugcugaacgu guaccugaag      180

agccaccacg gcgagcacga gagacccgag uucaucgccu acccccaccu gagaaucaga      240

accaagcccu uccccugggg cgacggcaac cacacccugu uccacaaccc ccacgugaac      300

ccccugccca ccggcuacga ggacgaguga                                       330


<210>  7239
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7239
auggccgugg ucggcguuag cuccgugucu agacugcucg ggcggagccg cccccagcug       60

ggaagaccua uguccucugg cgcucacggg gaggaaggaa gcgcccggau guggaagacc      120

cuuacauucu uuguggcgcu gccgggcguc gcugugucca ugcucaacgu uuaccugaaa      180

ucucaucacg gggagcauga acgccccgag uucaucgccu auccucaccu ucggauuaga      240

acgaagcccu uuccuugggg agacggcaau cauacccugu uccacaaccc ccacgugaau      300

ccucucccga caggcuacga agaugaguga                                       330


<210>  7240
<211>  330
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__CCF23108

<400>  7240
auggcaguag uaggaguauc aucaguauca agacuacuag gaagaucaag accacaacuc       60

ggaagaccaa ugucaucagg agcacacgga gaagaaggau cagcaagaau guggaaaaca      120

cuaacauucu ucguagcauu accaggagua gcaguaucaa ugcuaaacgu auaccuaaaa      180

ucacaucacg gagaacauga aagaccagaa uucauagcau acccacaccu aagaauaaga      240

acaaaaccau ucccaugggg agacggaaau cacacacuau uccacaaccc acacguaaac      300

ccacuaccaa caggauauga agacgaauaa                                       330


<210>  7241
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__O95101

<400>  7241

Met Ser Ser Gly Ala His Gly Glu Glu Gly Ser Ala Arg Met Trp Lys 
1               5                   10                  15      


Ala Leu Thr Tyr Phe Val Ala Leu Pro Gly Val Gly Val Ser Met Leu 
            20                  25                  30          


Asn Val Phe Leu Lys Ser Arg His Glu Glu His Glu Arg Pro Pro Phe 
        35                  40                  45              


Val Ala Tyr Pro His Leu Arg Ile Arg Thr Lys Pro Phe Pro Trp Gly 
    50                  55                  60                  


Asp Gly Asn His Thr Leu Phe His Asn Pro His Val Asn Pro Leu Pro 
65                  70                  75                  80  


Thr Gly Tyr Glu Asp Glu 
                85      


<210>  7242
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAC98895

<400>  7242
augucgagug gcgcccacgg cgaggagggu ucagcucgga uguggaaggc ccucaccuac       60

uucguggcgc ugcccggggu gggagugagc augcucaacg uguuccucaa gucgcggcac      120

gaagagcacg agagaccccc guucguugcc uacccucacc ugcgcaucag gaccaagccc      180

uuccccuggg gagacgguaa ccauacccuc uuccacaacc cucaugugaa cccacuuccg      240

accggcuaug aagaugagua a                                                261


<210>  7243
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7243
augagcagcg gcgcccacgg ggaggagggc agcgcccgca uguggaaggc gcugaccuac       60

uucguggccc uccccggggu cggcgugucc augcugaacg uguuccugaa gucccggcac      120

gaggagcacg agcgcccgcc cuucgucgcc uacccccacc uccggauccg caccaagccc      180

uucccguggg gcgacgggaa ccacacgcug uuccacaacc cccacgugaa cccccugccc      240

accggcuacg aggacgagug a                                                261


<210>  7244
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7244
auguccuccg gcgcccacgg cgaggagggc uccgcccgca uguggaaggc ccucaccuac       60

uucgucgccc uccccggcgu cggcgucucc augcucaacg ucuuccucaa gucccgccac      120

gaggagcacg agcgcccccc cuucgucgcc uacccccacc uccgcauccg caccaagccc      180

uuccccuggg gcgacggcaa ccacacccuc uuccacaacc cccacgucaa cccccucccc      240

accggcuacg aggacgagug a                                                261


<210>  7245
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7245
augagcuccg gcgcccacgg ggaggaagga ucugcuagaa uguggaaggc acugaccuac       60

uucguggccc uccccggugu cggcguuuca augcuuaacg uguuucugaa aaguaggcau      120

gaggaacacg agcggccucc auucguagcg uauccgcauu ugcgcauccg aacaaagccc      180

uuuccuuggg gagacgggaa ucacacuuua uuccauaacc cacacgugaa uccccugccu      240

acgggcuacg aagaugagug a                                                261


<210>  7246
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7246
augagcagcg gcgcccacgg cgaggagggc agcgccagaa uguggaaggc ccugaccuac       60

uucguggccc ugcccggcgu gggcgugagc augcugaacg uguuccugaa gagcagacac      120

gaggagcacg agagaccccc cuucguggcc uacccccacc ugagaaucag aaccaagccc      180

uuccccuggg gcgacggcaa ccacacccug uuccacaacc cccacgugaa cccccugccc      240

accggcuacg aggacgagug a                                                261


<210>  7247
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7247
augagcuccg gcgcccacgg ggaggaagga ucugcuagaa uguggaaggc ccugaccuac       60

uucguggcgc uccccggcgu cgggguuagc augcugaacg uguuucuuaa aucccggcau      120

gaggaacacg agcgcccucc guucguggcu uauccccauc ugagaauccg gacaaagccu      180

uuucccuggg gagacggcaa ucacacccuc uuccauaacc cucacgucaa uccccugccu      240

acgggguacg aagaugagug a                                                261


<210>  7248
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAC98895

<400>  7248
augucaucag gagcacacgg agaagaagga ucagcaagaa uguggaaagc acuaacauac       60

uucguagcac uaccaggagu aggaguauca augcuaaacg uauuccuaaa aucaagacac      120

gaagaacacg aaagaccacc auucguagca uacccacacc uaagaauaag aacaaaacca      180

uucccauggg gagacggaaa ccacacacua uuccacaacc cacacguaaa cccacuacca      240

acaggauacg aagacgaaua a                                                261


<210>  7249
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__P08574

<400>  7249

Met Ala Ala Ala Ala Ala Ser Leu Arg Gly Val Val Leu Gly Pro Arg 
1               5                   10                  15      


Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg Gly Leu Leu Cys Ser Ala 
            20                  25                  30          


Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ala Leu Ser 
        35                  40                  45              


Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu 
    50                  55                  60                  


Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Met Ala Leu His Ser 
65                  70                  75                  80  


Ala Val Ser Ala Ser Asp Leu Glu Leu His Pro Pro Ser Tyr Pro Trp 
                85                  90                  95      


Ser His Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg 
            100                 105                 110         


Gly Phe Gln Val Tyr Lys Gln Val Cys Ala Ser Cys His Ser Met Asp 
        115                 120                 125             


Phe Val Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Asp Glu 
    130                 135                 140                 


Ala Lys Glu Leu Ala Ala Glu Val Glu Val Gln Asp Gly Pro Asn Glu 
145                 150                 155                 160 


Asp Gly Glu Met Phe Met Arg Pro Gly Lys Leu Phe Asp Tyr Phe Pro 
                165                 170                 175     


Lys Pro Tyr Pro Asn Ser Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala 
            180                 185                 190         


Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu 
        195                 200                 205             


Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly 
    210                 215                 220                 


Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln 
225                 230                 235                 240 


Ala Ile Ala Met Ala Pro Pro Ile Tyr Thr Asp Val Leu Glu Phe Asp 
                245                 250                 255     


Asp Gly Thr Pro Ala Thr Met Ser Gln Ile Ala Lys Asp Val Cys Thr 
            260                 265                 270         


Phe Leu Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met 
        275                 280                 285             


Gly Leu Lys Met Leu Met Met Met Ala Leu Leu Val Pro Leu Val Tyr 
    290                 295                 300                 


Thr Ile Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala 
305                 310                 315                 320 


Tyr Arg Pro Pro Lys 
                325 


<210>  7250
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAV38601

<400>  7250
auggcggcag cugcggcuuc gcuucgcggg guaguguugg gcccgcgggg cgcggggcuc       60

ccgggcgcgc gugcccgggg ucugcugugc agcgcgcguc ccgggcagcu cccgcuacgg      120

acaccucagg caguggccuu gucgucgaag ucuggccuuu cccgaggccg gaaagugaug      180

cugucagcgc ugggcaugcu ggcggcaggg ggugcggggc uggccauggc ucugcauucg      240

gcugugagug ccagugaccu ggagcugcac ccccccagcu auccgugguc ucaccguggc      300

cuccucucuu ccuuggacca caccagcauc cggagggguu uccagguaua uaagcaggug      360

ugcgccuccu gccacagcau ggacuucgug gccuaccgcc accugguggg cgugugcuac      420

acggaggaug aagcuaagga gcuggcugcg gagguggagg uucaagacgg ccccaaugaa      480

gauggggaga uguucaugcg gccagggaag cuguucgacu auuucccaaa accauacccc      540

aacagugagg cugcucgagc ugccaacaac ggagcauugc ccccugaccu cagcuacauc      600

gugcgagcua ggcauggugg ugaggacuac gucuucuccc ugcucacggg cuacugcgag      660

ccacccaccg gggugucacu gcgggaaggu cucuacuuca accccuacuu uccuggccag      720

gccauugcca uggccccucc caucuacaca gaugucuuag aguuugacga uggcacccca      780

gcuaccaugu cccagauagc caaggaugug ugcaccuucc ugcgcugggc aucugagcca      840

gagcacgacc aucgaaaacg cauggggcuc aagauguuga ugaugauggc ucugcuggug      900

ccccuggucu acaccauaaa gcggcacaag uggucagucc ugaagagucg gaagcuggca      960

uaucggccgc ccaaguag                                                    978


<210>  7251
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7251
auggccgccg cggccgccag ccugcgcggc gugguccucg ggccccgcgg cgccgggcug       60

ccgggcgccc gcgcgcgggg gcugcucugc uccgcccgcc ccggccagcu gccccugcgg      120

acgccccagg ccguggcccu cagcuccaag agcggccugu cccgcgggcg gaaggugaug      180

cugagcgcgc ucggcaugcu ggccgccggg ggcgccgggc uggccauggc gcuccacucc      240

gccgucagcg ccuccgaccu ggagcugcac ccgcccagcu accccugguc ccaccgcggc      300

cuccugagcu cccuggacca caccagcauc cggcgcggcu uccaggugua caagcagguc      360

ugcgccuccu gccacagcau ggacuucgug gccuaccggc accucguggg ggugugcuac      420

accgaggacg aggcgaagga gcuggccgcc gaggucgagg ugcaggacgg ccccaacgag      480

gacggggaga uguucaugcg cccgggcaag cuguucgacu acuuccccaa gcccuacccc      540

aacuccgagg ccgcccgggc ggccaacaac ggcgcccucc cgcccgaccu gagcuacauc      600

gugcgcgccc ggcacggggg cgaggacuac gucuucuccc ugcucaccgg guacugcgag      660

ccgcccaccg gcgugagccu gcgcgagggg cuguacuuca accccuacuu ccccggccag      720

gccaucgcga uggccccgcc caucuacacc gacgugcucg aguucgacga cggcacgccc      780

gccaccauga gccagaucgc caaggacguc ugcaccuucc ugcggugggc guccgagccc      840

gagcacgacc accgcaagcg gauggggcug aagaugcuca ugaugauggc ccugcuggug      900

ccccucgugu acaccaucaa gcgccacaag uggagcgucc ugaagucccg gaagcuggcc      960

uaccggcccc cgaaguga                                                    978


<210>  7252
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7252
auggccgccg ccgccgccuc ccuccgcggc gucguccucg gcccccgcgg cgccggccuc       60

cccggcgccc gcgcccgcgg ccuccucugc uccgcccgcc ccggccagcu cccccuccgc      120

accccccagg ccgucgcccu cuccuccaag uccggccucu cccgcggccg caaggucaug      180

cucuccgccc ucggcaugcu cgccgccggc ggcgccggcc ucgccauggc ccuccacucc      240

gccgucuccg ccuccgaccu cgagcuccac ccccccuccu accccugguc ccaccgcggc      300

cuccucuccu cccucgacca caccuccauc cgccgcggcu uccaggucua caagcagguc      360

ugcgccuccu gccacuccau ggacuucguc gccuaccgcc accucgucgg cgucugcuac      420

accgaggacg aggccaagga gcucgccgcc gaggucgagg uccaggacgg ccccaacgag      480

gacggcgaga uguucaugcg ccccggcaag cucuucgacu acuuccccaa gcccuacccc      540

aacuccgagg ccgcccgcgc cgccaacaac ggcgcccucc cccccgaccu cuccuacauc      600

guccgcgccc gccacggcgg cgaggacuac gucuucuccc uccucaccgg cuacugcgag      660

ccccccaccg gcgucucccu ccgcgagggc cucuacuuca accccuacuu ccccggccag      720

gccaucgcca uggccccccc caucuacacc gacguccucg aguucgacga cggcaccccc      780

gccaccaugu cccagaucgc caaggacguc ugcaccuucc uccgcugggc cuccgagccc      840

gagcacgacc accgcaagcg caugggccuc aagaugcuca ugaugauggc ccuccucguc      900

ccccucgucu acaccaucaa gcgccacaag ugguccgucc ucaagucccg caagcucgcc      960

uaccgccccc ccaaguga                                                    978


<210>  7253
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7253
auggccgcug cagccgcgag ccugagaggc gugguccucg ggcccagggg agcuggucuu       60

ccuggcgccc gggcacgcgg gcuguugugc uccgcccgac caggacaguu accgcugcgu      120

acaccccaag cuguugcacu aucuucaaag aguggccuca gcagagguag gaaagugaug      180

cuguccgccc uugggaugcu ggcugccgga ggcgcgggcu uggcaauggc ccuccacucu      240

gcuguaucgg ccucagaccu ggagcugcau ccuccaagcu accccuggag ucaccggggg      300

cucuuauccu cucuggauca uaccagcauc cgcagaggau uccaggugua uaagcagguc      360

ugugcauccu gccacucaau ggacuuugug gcuuacaggc aucuuguugg uguguguuau      420

acugaagaug aggccaaaga auuggcggcc gaggucgaag ugcaggacgg cccuaacgag      480

gauggggaga uguucaugcg gccaggaaag cuguuugacu acuuccccaa accuuaucca      540

aauagugaag cagcucgcgc cgcuaacaau ggcgcccuac cgcccgaucu cagcuacauu      600

guacgagcaa gacacggugg ggaggacuau guguuuucuc ugcuuacggg auacugcgaa      660

ccuccaaccg gcguuucccu gagggagggc uuguacuuca accccuauuu uccugggcaa      720

gccauagcua uggcgccacc caucuacaca gauguccucg aguucgacga uggaacuccg      780

gcaaccaugu cacagauugc caaggacgug uguacauuuc ugcggugggc uagcgaaccu      840

gagcacgauc aucguaagcg cauggguuua aaaaugcuga ugaugauggc ccuccuugug      900

ccccuggucu auaccaucaa gagacacaaa uggaguguuu ugaagucuag gaaacuagca      960

uaccggccac cuaaguga                                                    978


<210>  7254
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7254
auggccgccg ccgccgccag ccugagaggc guggugcugg gccccagagg cgccggccug       60

cccggcgcca gagccagagg ccugcugugc agcgccagac ccggccagcu gccccugaga      120

accccccagg ccguggcccu gagcagcaag agcggccuga gcagaggcag aaaggugaug      180

cugagcgccc ugggcaugcu ggccgccggc ggcgccggcc uggccauggc ccugcacagc      240

gccgugagcg ccagcgaccu ggagcugcac ccccccagcu accccuggag ccacagaggc      300

cugcugagca gccuggacca caccagcauc agaagaggcu uccaggugua caagcaggug      360

ugcgccagcu gccacagcau ggacuucgug gccuacagac accugguggg cgugugcuac      420

accgaggacg aggccaagga gcuggccgcc gagguggagg ugcaggacgg ccccaacgag      480

gacggcgaga uguucaugag acccggcaag cuguucgacu acuuccccaa gcccuacccc      540

aacagcgagg ccgccagagc cgccaacaac ggcgcccugc cccccgaccu gagcuacauc      600

gugagagcca gacacggcgg cgaggacuac guguucagcc ugcugaccgg cuacugcgag      660

ccccccaccg gcgugagccu gagagagggc cuguacuuca accccuacuu ccccggccag      720

gccaucgcca uggccccccc caucuacacc gacgugcugg aguucgacga cggcaccccc      780

gccaccauga gccagaucgc caaggacgug ugcaccuucc ugagaugggc cagcgagccc      840

gagcacgacc acagaaagag aaugggccug aagaugcuga ugaugauggc ccugcuggug      900

ccccuggugu acaccaucaa gagacacaag uggagcgugc ugaagagcag aaagcuggcc      960

uacagacccc ccaaguga                                                    978


<210>  7255
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7255
auggccgcug ccgcggcuag ccugagaggc gugguccucg ggccccgggg agccggccug       60

ccuggggccc gcgcuagagg acuucugugc uccgcccggc cgggccagcu cccccugcgc      120

accccucaag cuguugcccu uucuagcaag uccgggcugu cuagaggacg gaaagugaug      180

cucagcgcgc ugggcaugcu ggccgcuggc ggggccggac ucgcuauggc ccugcacucc      240

gcggugucug ccagcgaccu ugagcugcau cccccuuccu accccuggag ccaccgcggc      300

cuccugucuu cccuugauca uacaagcauc agacgggggu uccaggucua uaaacaggug      360

ugugcuucuu gccacuccau ggacuuuguu gccuaccgcc aucugguggg agucuguuau      420

acggaagaug aggcuaagga acucgccgcc gagguggaag uucaggacgg cccuaacgag      480

gauggggaga uguucaugag accgggaaag cuguuugacu acuuccccaa accuuauccc      540

aauagcgaag cugcgcgggc cgcuaacaau ggcgcccugc cucccgaucu cucuuacauu      600

gugcgcgcca gacacggcgg ggaggacuau gucuuuuccc ugcuuaccgg auacugcgaa      660

ccgccuacag gcgugagccu gcgggagggg cucuacuuca accccuauuu uccuggacaa      720

gcuaucgcca uggcgccucc cauuuacacc gaugugcugg aguucgacga uggcacaccc      780

gcuaccaugu cccagaucgc caaggacguc uguacauuuc uucgcugggc cucugaaccg      840

gagcacgauc auagaaagcg gauggggcug aaaaugcuca ugaugauggc ucugcugguu      900

ccccucgugu auaccauuaa gagacacaaa uggagcgugc ugaagucccg caaacuugcc      960

uaccggccuc ccaaguga                                                    978


<210>  7256
<211>  978
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAV38601

<400>  7256
auggcagcag cagcagcauc auuacgugga guaguacuag gaccuagagg agcaggauua       60

ccaggagcua gagcaagagg auuauuaugu ucugcacgac caggacaacu uccauuaaga      120

acuccacaag ccguugcauu aucaucaaaa ucuggacuuu cacgaggaag aaaaguaaug      180

uuaucagcac uaggaaugcu agccgcagga ggagcaggau uagcaauggc cuuacauuca      240

gcaguaucag cuucagacuu agaacuacac ccuccgucau auccauggag ucaucgagga      300

cuacuaaguu cauuagauca uacaucaaua agaagaggau uucaaguaua uaaacaagua      360

ugugcaucau gucauucaau ggauuuugua gccuacagac auuuaguugg aguauguuau      420

acagaagacg aagcaaaaga auuagccgca gaaguugaag uacaagaugg accaaaugaa      480

gauggagaaa uguuuaugag accuggaaaa uuauuugacu auuuuccaaa accauaccca      540

aauagcgaag cagcaagagc cgcaaauaau ggagcacuac cuccugaucu uucauauauu      600

gucagagcaa gacauggugg ugaagauuau guauuuucau uacuaacagg auauugugaa      660

ccaccuacag gaguaucauu aagagaagga uuauacuuua acccauauuu uccaggacaa      720

gcaauagcua uggcaccacc aauauauaca gauguauuag aauuugacga uggaacaccu      780

gcaacaaugu cacaaauagc aaaagaugua uguacauuuu uacgaugggc aucagaacca      840

gaacaugauc aucguaaaag aaugggauua aaaauguuaa ugaugauggc auuauuaguu      900

ccuuuaguuu auacuauaaa acgacauaaa uggaguguuu uaaaauccag aaaauuagca      960

uauagaccuc caaaauaa                                                    978


<210>  7257
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__P99999

<400>  7257

Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser 
1               5                   10                  15      


Gln Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn 
            20                  25                  30          


Leu His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser 
        35                  40                  45              


Tyr Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr 
    50                  55                  60                  


Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys 
65                  70                  75                  80  


Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile 
                85                  90                  95      


Ala Tyr Leu Lys Lys Ala Thr Asn Glu 
            100                 105 


<210>  7258
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAA35732

<400>  7258
augggugaug uugagaaagg caagaagauu uuuauuauga aguguuccca gugccacacc       60

guugaaaagg gaggcaagca caagacuggg ccaaaucucc auggucucuu ugggcggaag      120

acaggucagg ccccuggaua cucuuacaca gccgccaaua agaacaaagg caucaucugg      180

ggagaggaua cacugaugga guauuuggag aaucccaaga aguacauccc uggaacaaaa      240

augaucuuug ucggcauuaa gaagaaggaa gaaagggcag acuuaauagc uuaucucaaa      300

aaagcuacua augaguaa                                                    318


<210>  7259
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7259
augggcgacg uggagaaggg gaagaagauc uucaucauga agugcagcca gugccacacc       60

gucgagaagg gcgggaagca caagaccggc cccaaccugc acggccucuu cgggcgcaag      120

acgggccagg ccccggggua cuccuacacc gccgcgaaca agaacaaggg caucaucugg      180

ggcgaggaca cccugaugga guaccuggag aaccccaaga aguacauccc cgggaccaag      240

augaucuucg uggggaucaa gaagaaggag gagcgggccg accucaucgc cuaccugaag      300

aaggccacga acgaguga                                                    318


<210>  7260
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7260
augggcgacg ucgagaaggg caagaagauc uucaucauga agugcuccca gugccacacc       60

gucgagaagg gcggcaagca caagaccggc cccaaccucc acggccucuu cggccgcaag      120

accggccagg cccccggcua cuccuacacc gccgccaaca agaacaaggg caucaucugg      180

ggcgaggaca cccucaugga guaccucgag aaccccaaga aguacauccc cggcaccaag      240

augaucuucg ucggcaucaa gaagaaggag gagcgcgccg accucaucgc cuaccucaag      300

aaggccacca acgaguga                                                    318


<210>  7261
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7261
augggcgacg uggagaaggg gaaaaagauc uucauuauga aaugcagcca gugucacacc       60

gucgaaaagg gagguaaaca uaagacaggc cccaaccugc acgggcucuu uggaagaaag      120

acuggccaag ccccugguua cuccuauacg gcugcaaaua aaaacaaggg gauaaucugg      180

ggagaggaua cccuuaugga auaccuggag aauccgaaaa aguauauucc aggcacaaaa      240

augaucuucg uuggcauuaa gaagaaagaa gagagggccg acuugaucgc guacuuaaag      300

aaagcuacua acgaguga                                                    318


<210>  7262
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7262
augggcgacg uggagaaggg caagaagauc uucaucauga agugcagcca gugccacacc       60

guggagaagg gcggcaagca caagaccggc cccaaccugc acggccuguu cggcagaaag      120

accggccagg cccccggcua cagcuacacc gccgccaaca agaacaaggg caucaucugg      180

ggcgaggaca cccugaugga guaccuggag aaccccaaga aguacauccc cggcaccaag      240

augaucuucg ugggcaucaa gaagaaggag gagagagccg accugaucgc cuaccugaag      300

aaggccacca acgaguga                                                    318


<210>  7263
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7263
augggcgacg uggagaaggg gaaaaagauc uucauuauga aaugcagcca gugucacacc       60

gucgaaaagg gaggcaaaca uaagacaggg cccaaccugc acggacucuu uggcagaaag      120

acggggcaag ccccuggaua cuccuauacc gcugccaaua aaaacaaggg caucauuugg      180

ggcgaggaua cacugaugga auaccuugag aauccgaaaa aguauauccc cgggaccaaa      240

augauuuucg uuggaaucaa gaagaaagag gaacgggcgg accugaucgc uuaccucaag      300

aaagccacaa acgaguga                                                    318


<210>  7264
<211>  318
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAA35732

<400>  7264
augggagacg uagaaaaagg aaaaaaaaua uucauaauga aaugcagcca augccacaca       60

guagaaaaag gaggaaaaca caaaacagga ccaaaccuac acggacuauu cggaagaaaa      120

acaggacaag caccaggaua cagcuacaca gcagcaaaca aaaacaaagg aauaauaugg      180

ggagaagaca cacuaaugga auaccuagaa aacccaaaaa aauacauacc aggaacaaaa      240

augauauucg uaggaauaaa aaaaaaagaa gaaagagcag accuaauagc auaccuaaaa      300

aaagcaacaa acgaauaa                                                    318


<210>  7265
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q496I0

<400>  7265

Met Leu Trp Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
1               5                   10                  15      


Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
            20                  25                  30          


Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
        35                  40                  45              


Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
    50                  55                  60                  


Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
65                  70                  75                  80  


Lys Gln Glu 
            


<210>  7266
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAI00853

<400>  7266
augcugugga aucugcuggc ucuucgucag auugggcaga ggacgauaag cacugcuucc       60

cgcaggcauu uuaaaaauaa aguuccggag aagcaaaaac uguuccagga ggaugaugaa      120

auuccacugu aucuaaaggg ugggguagcu gaugcccucc uguauagagc caccaugauu      180

cuuacaguug guggaacagc auaugccaua uaugagcugg cuguggcuuc auuucccaag      240

aagcaggagu ga                                                          252


<210>  7267
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7267
augcugugga accuccuggc ccugcgccag aucggccagc ggaccaucag caccgccucc       60

cgccggcacu ucaagaacaa ggugcccgag aagcagaagc uguuccagga ggacgacgag      120

aucccgcucu accugaaggg cgggguggcg gacgcccucc uguaccgcgc cacgaugauc      180

cugaccgucg ggggcaccgc cuacgccauc uacgagcucg cgguggccag cuuccccaag      240

aagcaggagu ga                                                          252


<210>  7268
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7268
augcucugga accuccucgc ccuccgccag aucggccagc gcaccaucuc caccgccucc       60

cgccgccacu ucaagaacaa gguccccgag aagcagaagc ucuuccagga ggacgacgag      120

aucccccucu accucaaggg cggcgucgcc gacgcccucc ucuaccgcgc caccaugauc      180

cucaccgucg gcggcaccgc cuacgccauc uacgagcucg ccgucgccuc cuuccccaag      240

aagcaggagu ga                                                          252


<210>  7269
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7269
augcugugga accuccuugc ccugagacag aucggccaaa ggaccauuag cacagcuucc       60

cggcgccacu ucaagaauaa agugcccgag aagcagaaau uguuucagga agacgaugag      120

auaccuuuau accugaaagg gggagucgca gacgcccuac ucuaucgagc gacuaugauc      180

cugacgguug guggcaccgc uuacgccauu uaugaacuug caguggccuc uuucccaaag      240

aagcaggagu ga                                                          252


<210>  7270
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7270
augcugugga accugcuggc ccugagacag aucggccaga gaaccaucag caccgccagc       60

agaagacacu ucaagaacaa ggugcccgag aagcagaagc uguuccagga ggacgacgag      120

aucccccugu accugaaggg cggcguggcc gacgcccugc uguacagagc caccaugauc      180

cugaccgugg gcggcaccgc cuacgccauc uacgagcugg ccguggccag cuuccccaag      240

aagcaggagu ga                                                          252


<210>  7271
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7271
augcugugga accuccuggc ccuuagacag aucggccaac ggaccauuag cacagcuucc       60

cgcagacacu ucaagaauaa agugcccgag aagcagaaac uguuucagga agacgaugag      120

aucccucucu accugaaagg gggagucgcc gacgcgcuuc uguaucgggc uacgaugauu      180

cucaccguug gcgggacagc cuacgccauc uaugaacugg cuguggccuc uuucccgaag      240

aagcaggagu ga                                                          252


<210>  7272
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAI00853

<400>  7272
augcuaugga accuacuagc acuaagacaa auaggacaaa gaacaauauc aacagcaagc       60

agaagacacu ucaaaaacaa aguaccagaa aaacaaaaac uauuccaaga agacgacgaa      120

auaccacuau accuaaaagg aggaguagca gacgcacuac uauacagagc aacaaugaua      180

cuaacaguag gaggaacagc auacgcaaua uacgaacuag caguagcauc auucccaaaa      240

aaacaagaau aa                                                          252


<210>  7273
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q53XN1

<400>  7273

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu Gly Ile Met Glu Leu Ala Val Gly Leu Thr Ser Cys Phe 
        35                  40                  45              


Val Thr Phe Leu Leu Pro Ala Gly Trp Ile Leu Ser His Leu Glu Thr 
    50                  55                  60                  


Tyr Arg Arg Pro Glu 
65                  


<210>  7274
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAP88805

<400>  7274
auguccgucc ugacgccgcu gcugcugcgg ggcuugacag gcucggcccg gcggcuccca       60

gugccgcgcg ccaagaucca uucguugccg ccggagggga agcuugggau cauggaauug      120

gccguugggc uuaccuccug cuucgugacc uuccuccugc cagcgggcug gauccuguca      180

caccuggaga ccuacaggag gccagaguag                                       210


<210>  7275
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7275
augagcgugc ugacgccccu ccugcugcgc ggccucaccg gguccgcccg gcgccugccg       60

gucccccggg ccaagaucca cagccugccg cccgagggca agcucgggau cauggagcug      120

gcggugggcc ugaccuccug cuucgugacc uuccuccugc ccgccgggug gauccugagc      180

caccucgaga ccuaccgccg gcccgaguga                                       210


<210>  7276
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7276
auguccgucc ucaccccccu ccuccuccgc ggccucaccg gcuccgcccg ccgccucccc       60

gucccccgcg ccaagaucca cucccucccc cccgagggca agcucggcau cauggagcuc      120

gccgucggcc ucaccuccug cuucgucacc uuccuccucc ccgccggcug gauccucucc      180

caccucgaga ccuaccgccg ccccgaguga                                       210


<210>  7277
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7277
augagcgugc ugacaccccu ccuucugaga ggcuugaccg gguccgccag gcgguuaccu       60

gucccacgcg cuaagaucca cucucugccg cccgagggaa aacuagguau uauggaacuc      120

gcaguuggcc ugacuucaug cuucgugacg uuucuucugc cugccgggug gauauugagu      180

caucucgaga ccuaccgacg uccagaauga                                       210


<210>  7278
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7278
augagcgugc ugaccccccu gcugcugaga ggccugaccg gcagcgccag aagacugccc       60

gugcccagag ccaagaucca cagccugccc cccgagggca agcugggcau cauggagcug      120

gccgugggcc ugaccagcug cuucgugacc uuccugcugc ccgccggcug gauccugagc      180

caccuggaga ccuacagaag acccgaguga                                       210


<210>  7279
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7279
augagcgugc ugacaccccu ccugcuuaga ggccugaccg gguccgcccg gcgccucccu       60

gucccgagag cuaagaucca cucucugccc ccugagggaa aacuuggcau uauggaacug      120

gccguugggc ucacgagcug cuucgugacc uuucugcugc ccgcgggaug gauccucucc      180

caucuggaga cauaccggcg cccugaauga                                       210


<210>  7280
<211>  210
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAP88805

<400>  7280
augucaguac uaacaccacu acuacuaaga ggacuaacag gaucagcaag aagacuacca       60

guaccaagag caaaaauaca cucacuacca ccagaaggaa aauuaggcau aauggaacua      120

gcaguaggac uaacaucaug uuucguaaca uuccuacuac cagcaggaug gauacuauca      180

caccuagaaa cauacagaag accagaauaa                                       210


<210>  7281
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q6FGA0

<400>  7281

Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp 
1               5                   10                  15      


Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr 
            20                  25                  30          


Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp 
        35                  40                  45              


Ser Thr Val Tyr Asp Tyr Ala Gly Lys Asn Lys Val Pro Glu Leu Gln 
    50                  55                  60                  


Lys Phe Phe Gln Lys Ala Asp Gly Val Pro Val Tyr Leu Lys Arg Gly 
65                  70                  75                  80  


Leu Pro Asp Gln Met Leu Tyr Arg Thr Thr Met Ala Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ile Tyr Cys Leu Ile Ala Leu Tyr Met Ala Ser Gln Pro Lys 
            100                 105                 110         


Asn Lys 
        


<210>  7282
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAY15087

<400>  7282
auguacuaca aguuuagugg cuucacgcag aaguuggcag gagcaugggc uucggaggcc       60

uauagcccgc agggauuaaa gccugugguu uccacagaag caccaccuau cauauuugcc      120

acaccaacua aacugaccuc cgauuccaca guguaugauu augcugggaa aaacaaaguu      180

ccagagcuac aaaaguuuuu ccagaaagcu gauggugugc ccgucuaccu gaaacgaggc      240

cugccugacc aaaugcuuua ccggaccacc auggcgcuga cugugggagg gaccaucuac      300

ugccugaucg cccucuacau ggcuucgcag cccaaaaaca aauga                      345


<210>  7283
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7283
auguacuaca aguucagcgg cuucacccag aagcuggccg gggccugggc guccgaggcc       60

uacagccccc agggccucaa gccggugguc uccaccgagg ccccgcccau caucuucgcc      120

acgcccacca agcugaccag cgacuccacc guguacgacu acgccgggaa gaacaaggug      180

cccgagcugc agaaguucuu ccagaaggcg gacggcgucc ccguguaccu caagcgcggg      240

cugcccgacc agaugcugua ccggacgacc auggcccuca ccgugggcgg caccaucuac      300

ugccugaucg cccuguacau ggccagccag cccaagaaca aguga                      345


<210>  7284
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7284
auguacuaca aguucuccgg cuucacccag aagcucgccg gcgccugggc cuccgaggcc       60

uacucccccc agggccucaa gcccgucguc uccaccgagg ccccccccau caucuucgcc      120

acccccacca agcucaccuc cgacuccacc gucuacgacu acgccggcaa gaacaagguc      180

cccgagcucc agaaguucuu ccagaaggcc gacggcgucc ccgucuaccu caagcgcggc      240

cuccccgacc agaugcucua ccgcaccacc auggcccuca ccgucggcgg caccaucuac      300

ugccucaucg cccucuacau ggccucccag cccaagaaca aguga                      345


<210>  7285
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7285
auguacuaua aguucagcgg cuuuacccag aaacuggccg gggcuugggc auccgaggcc       60

uacucucccc aaggacucaa gccugugguc ucaacagaag cgccaccgau cauuuucgcu      120

acucccacga aacuuaccag ugacagcaca guuuaugauu acgccgguaa gaacaaagug      180

ccugagcugc agaaguuuuu ccagaaggca gacggcguac caguguauuu gaaaagaggg      240

uuacccgauc agaugcugua caggacuacc auggcccuaa cagucggagg caccauauau      300

ugccucaucg cucuguacau ggcaucccaa ccuaagaaua aauga                      345


<210>  7286
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7286
auguacuaca aguucagcgg cuucacccag aagcuggccg gcgccugggc cagcgaggcc       60

uacagccccc agggccugaa gcccguggug agcaccgagg ccccccccau caucuucgcc      120

acccccacca agcugaccag cgacagcacc guguacgacu acgccggcaa gaacaaggug      180

cccgagcugc agaaguucuu ccagaaggcc gacggcgugc ccguguaccu gaagagaggc      240

cugcccgacc agaugcugua cagaaccacc auggcccuga ccgugggcgg caccaucuac      300

ugccugaucg cccuguacau ggccagccag cccaagaaca aguga                      345


<210>  7287
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7287
auguacuaua aguucagcgg cuuuacccag aaacuggccg gggcuugggc cuccgaggcg       60

uacucucccc aaggacucaa gccugugguc agcacagaag cuccgcccau cauuuucgcc      120

acgccuacca aacugacauc cgacucuacc guuuaugauu acgccggcaa gaacaaagug      180

cccgagcuuc agaaguuuuu ccagaaggcu gacggggugc cugucuaucu gaaaagagga      240

cuccccgauc agaugcugua ccggacaacc auggcccuua cagugggcgg gaccaucuau      300

ugccugauug cucucuacau ggccagccaa ccuaagaaua aauga                      345


<210>  7288
<211>  345
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAY15087

<400>  7288
auguacuaca aauucucagg auucacacaa aaacuagcag gagcaugggc aucagaagca       60

uacucaccac aaggacuaaa accaguagua ucaacagaag caccaccaau aauauucgca      120

acaccaacaa aacuaacauc agacucaaca guauacgacu acgcaggaaa aaacaaagua      180

ccagaacuac aaaaauucuu ccaaaaagca gacggaguac caguauacuu aaaaagagga      240

cuaccagacc aaaugcuaua cagaacaaca auggcacuaa caguaggagg aacaauauac      300

ugccuaauag cacuauacau ggcaucacaa ccaaaaaaca aauaa                      345


<210>  7289
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q6FGI7

<400>  7289

Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser 
1               5                   10                  15      


Thr Ala Arg Asn Arg Phe Gln Asn Arg Val Arg Glu Lys Gln Lys Leu 
            20                  25                  30          


Phe Gln Glu Asp Asn Asp Ile Pro Leu Tyr Leu Lys Gly Gly Ile Val 
        35                  40                  45              


Asp Asn Ile Leu Tyr Arg Val Thr Met Thr Leu Cys Leu Gly Gly Thr 
    50                  55                  60                  


Val Tyr Ser Leu Tyr Ser Leu Gly Trp Ala Ser Phe Pro Arg Asn 
65                  70                  75                  


<210>  7290
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAP35570

<400>  7290
augcaggccc uucggguguc ccaggcgcug auccgcuccu ucagcuccac cgcccggaac       60

cgcuuucaga accgagugcg cgagaaacag aagcucuucc aggaggacaa ugacaucccg      120

uuguaccuga agggcggcau cguugacaac auccuguacc gagugacaau gacgcugugu      180

cugggcggca cugucuacag cuuguacucc cuuggcuggg ccuccuuccc caggaauuag      240


<210>  7291
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7291
augcaggccc ugcgcgugag ccaggcccuc auccgguccu ucagcuccac cgcgcgcaac       60

cgguuccaga accgcguccg ggagaagcag aagcuguucc aggaggacaa cgacaucccc      120

cuguaccuca agggcgggau cguggacaac auccuguacc gcgugaccau gacgcugugc      180

cucggcggga ccgucuacag ccuguacucc cugggcuggg ccagcuuccc gcggaacuga      240


<210>  7292
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7292
augcaggccc uccgcgucuc ccaggcccuc auccgcuccu ucuccuccac cgcccgcaac       60

cgcuuccaga accgcguccg cgagaagcag aagcucuucc aggaggacaa cgacaucccc      120

cucuaccuca agggcggcau cgucgacaac auccucuacc gcgucaccau gacccucugc      180

cucggcggca ccgucuacuc ccucuacucc cucggcuggg ccuccuuccc ccgcaacuga      240


<210>  7293
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7293
augcaggccc ugagagugag ccaagcucuc aucagguccu ucucuucaac cgcacggaac       60

cgcuuucaga aucgaguccg ugagaagcag aaacuuuucc aggaagacaa cgauauuccc      120

cuguacuuga agggcgggau aguugacaau aucuuauaua gagugacaau gacucugugc      180

cuaggaggua cgguauacag ucucuauagc cugggcuggg ccuccuuucc uaggaacuga      240


<210>  7294
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7294
augcaggccc ugagagugag ccaggcccug aucagaagcu ucagcagcac cgccagaaac       60

agauuccaga acagagugag agagaagcag aagcuguucc aggaggacaa cgacaucccc      120

cuguaccuga agggcggcau cguggacaac auccuguaca gagugaccau gacccugugc      180

cugggcggca ccguguacag ccuguacagc cugggcuggg ccagcuuccc cagaaacuga      240


<210>  7295
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7295
augcaggccc ugagagugag ccaagcucuc auccgguccu ucucuagcac cgcccgcaac       60

agauuucaga aucggguccg cgagaagcag aaacuguucc aggaagacaa cgauauuccc      120

cuuuaccuga agggcgggau cguugacaau auucucuaua gagugacaau gacgcugugc      180

cuuggaggca ccguguacuc ccuguauucu cucggguggg cgagcuuucc ucggaacuga      240


<210>  7296
<211>  240
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAP35570

<400>  7296
augcaagcac uaagaguauc acaagcacua auaagaucau ucucaucaac agcaagaaac       60

agauuccaaa acagaguaag agaaaaacaa aaacuauucc aagaagacaa cgacauacca      120

cuauaccuaa aaggaggaau aguagacaac auacuauaca gaguaacaau gacacuaugc      180

cuaggaggaa caguauacuc acuauacuca cuaggauggg caucauuccc aagaaacuaa      240


<210>  7297
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q71U45

<400>  7297

Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg 
1               5                   10                  15      


Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu 
            20                  25                  30          


Asn Lys Trp Arg Leu Leu Ala Met Met Thr Val Tyr Phe Gly Ser Gly 
        35                  40                  45              


Phe Ala Ala Pro Phe Phe Ile Val Arg His Gln Leu Leu Lys Lys 
    50                  55                  60              


<210>  7298
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAP97260

<400>  7298
auguugggcc agaguauccg gagguucacg accuccgugg uccgucgcag ccacuaugag       60

gaggguccgg ggaagaauuu gccauuuuca guggaaaaca aguggcgguu gcuggcuaug      120

augaccgugu acuuuggauc uggguuugcc gcaccuuucu uuauaguaag acaccagcua      180

cuuaaaaaau aa                                                          192


<210>  7299
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7299
augcugggcc agagcauccg ccgguucacc accuccgugg uccgccggag ccacuacgag       60

gaggggcccg gcaagaaccu cccguucucc guggagaaca aguggcgccu gcuggccaug      120

augacggugu acuucgggag cggcuucgcc gcgcccuucu ucaucguccg gcaccagcuc      180

cugaagaagu ga                                                          192


<210>  7300
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7300
augcucggcc aguccauccg ccgcuucacc accuccgucg uccgccgcuc ccacuacgag       60

gagggccccg gcaagaaccu ccccuucucc gucgagaaca aguggcgccu ccucgccaug      120

augaccgucu acuucggcuc cggcuucgcc gcccccuucu ucaucguccg ccaccagcuc      180

cucaagaagu ga                                                          192


<210>  7301
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7301
augcugggcc agagcaucag aagguucacc acauccgugg uccggcgcuc ucacuacgag       60

gaagggcccg gaaagaaccu cccuuuuuca guugagaaua aauggcgacu ucuggccaug      120

augacugugu auuucgguag uggcuuugcu gcaccauucu uuauuguacg ucaucaauug      180

uuaaagaaau ga                                                          192


<210>  7302
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7302
augcugggcc agagcaucag aagauucacc accagcgugg ugagaagaag ccacuacgag       60

gagggccccg gcaagaaccu gcccuucagc guggagaaca aguggagacu gcuggccaug      120

augaccgugu acuucggcag cggcuucgcc gcccccuucu ucaucgugag acaccagcug      180

cugaagaagu ga                                                          192


<210>  7303
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7303
augcugggcc agagcaucag acgguucacc acauccgugg uccgcagauc ucacuacgag       60

gaagggcccg gaaagaaccu cccuuuuagc guugagaaua aauggcggcu gcuugccaug      120

augacggugu auuucggcuc cggguuugcu gccccguucu uuauugugcg ccaucaacug      180

cucaagaaau ga                                                          192


<210>  7304
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAP97260

<400>  7304
augcuaggac aaucaauaag aagauucaca acaucaguag uaagaagauc acacuacgaa       60

gaaggaccag gaaaaaaccu accauucuca guagaaaaca aauggagacu acuagcaaug      120

augacaguau acuucggauc aggauucgca gcaccauucu ucauaguaag acaccaacua      180

cuaaaaaaau aa                                                          192


<210>  7305
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q86WV2

<400>  7305

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15      


Thr Ser Val Cys Val Arg Ala His Glu Ser Val Val Lys Ser Glu Asp 
            20                  25                  30          


Phe Ser Leu Pro Ala Tyr Met Asp Arg Arg Asp His Pro Leu Pro Glu 
        35                  40                  45              


Val Ala His Val Lys His Leu Ser Ala Ser Gln Lys Ala Leu Lys Glu 
    50                  55                  60                  


Lys Glu Lys Ala Ser Trp Ser Ser Leu Ser Met Asp Glu Lys Val Glu 
65                  70                  75                  80  


Cys Gly Tyr 
            


<210>  7306
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAH47869

<400>  7306
auguuggcua ccaggguauu uagccuaguu ggcaagcgag caauuuccac cucugugugu       60

guacgagcuc augaaagugu ugugaagagc gaagacuuuu cgcucccagc uuauauggau      120

cggcgugacc accccuugcc ggagguggcc caugucaagc accugucugc cagccagaag      180

gcacugaagg agaaggagaa ggccuccugg agcagccucu ccauggauga gaaagucgag      240

uguggguauu ga                                                          252


<210>  7307
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7307
augcuggcca cccgcguguu cagccucguc ggcaagcggg ccaucuccac cagcgugugc       60

gugcgcgcgc acgaguccgu cgucaagagc gaggacuucu cccugcccgc cuacauggac      120

cggcgcgacc acccgcugcc cgagguggcc cacgugaagc accucagcgc cucccagaag      180

gcccugaagg agaaggagaa ggcgagcugg uccagccugu ccauggacga gaagguggag      240

ugcggguacu ga                                                          252


<210>  7308
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7308
augcucgcca cccgcgucuu cucccucguc ggcaagcgcg ccaucuccac cuccgucugc       60

guccgcgccc acgaguccgu cgucaagucc gaggacuucu cccuccccgc cuacauggac      120

cgccgcgacc acccccuccc cgaggucgcc cacgucaagc accucuccgc cucccagaag      180

gcccucaagg agaaggagaa ggccuccugg uccucccucu ccauggacga gaaggucgag      240

ugcggcuacu ga                                                          252


<210>  7309
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7309
augcuggcca ccagaguguu cagccucguc ggcaagaggg cuaucuccac aucuguuugc       60

gugcgggcac acgagucagu agugaaaagu gaagacuuua gccuucccgc cuacauggau      120

cgccgagacc auccucugcc agaggucgcg cacgugaagc auuuguccgc uucucagaaa      180

gccuuaaagg aaaaagagaa ggcaucgugg ucaagccuga guauggauga aaagguugag      240

uguggguauu ga                                                          252


<210>  7310
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7310
augcuggcca ccagaguguu cagccuggug ggcaagagag ccaucagcac cagcgugugc       60

gugagagccc acgagagcgu ggugaagagc gaggacuuca gccugcccgc cuacauggac      120

agaagagacc acccccugcc cgagguggcc cacgugaagc accugagcgc cagccagaag      180

gcccugaagg agaaggagaa ggccagcugg agcagccuga gcauggacga gaagguggag      240

ugcggcuacu ga                                                          252


<210>  7311
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7311
augcuggcca ccagaguguu cagccucguc ggcaagcggg cuaucuccac aucuguuugc       60

gugcgcgccc acgagagcgu ggucaaaucc gaagacuuuu cucugcccgc guacauggau      120

agacgggacc auccucuucc ggagguggcu cacguuaagc aucugagcgc cucccagaaa      180

gcccucaagg aaaaagagaa ggcuucuugg agcucccuga gcauggauga aaagguggag      240

uguggguauu ga                                                          252


<210>  7312
<211>  252
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAH47869

<400>  7312
augcuagcaa caagaguauu uagccuagua ggaaaaagag caauaagcac aagcguaugc       60

guaagagcac acgaaagcgu aguaaaaagc gaagacuuua gcuuaccagc auacauggac      120

agaagagauc acccacuacc agaaguagca cauguaaaac acuuaagcgc aagccaaaaa      180

gcacuaaaag aaaaagaaaa agcaucaugg ucaagcuuaa gcauggacga aaaaguagaa      240

uguggauauu aa                                                          252


<210>  7313
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__Q9UEG9

<400>  7313

Met Ser Ser Gly Ala His Gly Glu Glu Gly Ser Ala Arg Met Trp Lys 
1               5                   10                  15      


Thr Leu Thr Phe Phe Val Ala Leu Pro Gly Val Ala Val Ser Met Leu 
            20                  25                  30          


Asn Val Tyr Leu Lys Ser His His Gly Glu His Glu Arg Pro Glu Phe 
        35                  40                  45              


Ile Ala Tyr Pro His Leu Arg Ile Arg Thr Lys Pro Phe Pro Trp Gly 
    50                  55                  60                  


Asp Gly Asn His Thr Leu Phe His Asn Pro His Val Asn Pro Leu Pro 
65                  70                  75                  80  


Thr Gly Tyr Glu Asp Glu 
                85      


<210>  7314
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cytochrome_c__Homo_sapiens__AAD00554

<400>  7314
augucgagug gcgcccaugg cgaagagggc ucagcucgca uguggaagac ucucaccuuc       60

uucgucgcgc uccccggggu ggcagucagc augcugaaug uguaccugaa gucgcaccac      120

ggagagcacg agagacccga guucaucgcc uacccccauc uccgcaucag gaccaagccg      180

uuucccuggg gagaugguaa ccauacucua uuccauaacc cucaugugaa uccacuucca      240

acuggcuacg aagaugaaua a                                                261


<210>  7315
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7315
augagcagcg gcgcccacgg ggaggagggc agcgcccgca uguggaagac ccugaccuuc       60

uucguggcgc uccccggggu cgccgugucc augcugaacg uguaccugaa gucccaccac      120

ggcgagcacg agcggccgga guucaucgcc uacccccacc uccgcauccg gacgaagccc      180

uuccccuggg gcgacgggaa ccacacccug uuccacaacc cgcacgucaa cccccugccc      240

accggcuacg aggacgagug a                                                261


<210>  7316
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7316
auguccuccg gcgcccacgg cgaggagggc uccgcccgca uguggaagac ccucaccuuc       60

uucgucgccc uccccggcgu cgccgucucc augcucaacg ucuaccucaa gucccaccac      120

ggcgagcacg agcgccccga guucaucgcc uacccccacc uccgcauccg caccaagccc      180

uuccccuggg gcgacggcaa ccacacccuc uuccacaacc cccacgucaa cccccucccc      240

accggcuacg aggacgagug a                                                261


<210>  7317
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7317
augagcuccg gcgcccacgg ggaggaagga ucugcuagaa uguggaagac ccugacauuc       60

uuuguggcac uccccggugu cgccguuuca augcuuaacg uguaccugaa aagucaucac      120

ggcgagcaug aaaggccuga guucaucgcg uauccacacu ugcggauucg cacuaagccg      180

uuucccuggg gagacgggaa ucauacguua uuccacaacc cucacguaaa uccacugccc      240

accggcuacg aagaugagug a                                                261


<210>  7318
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7318
augagcagcg gcgcccacgg cgaggagggc agcgccagaa uguggaagac ccugaccuuc       60

uucguggccc ugcccggcgu ggccgugagc augcugaacg uguaccugaa gagccaccac      120

ggcgagcacg agagacccga guucaucgcc uacccccacc ugagaaucag aaccaagccc      180

uuccccuggg gcgacggcaa ccacacccug uuccacaacc cccacgugaa cccccugccc      240

accggcuacg aggacgagug a                                                261


<210>  7319
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7319
augagcuccg gcgcccacgg ggaggaagga ucugcuagaa uguggaagac ccugacauuc       60

uuuguggccc uccccggcgu cgcgguuagc augcugaacg uguaccuuaa aucccaucac      120

ggggagcaug aacggccuga guucaucgcu uauccgcauc ugcgcauuag aacgaagccc      180

uuuccuuggg gagacggcaa ucacacccuc uuccacaacc cccacgugaa uccucugccc      240

acaggguacg aagaugagug a                                                261


<210>  7320
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Cytochrome_c__Homo_sapiens__AAD00554

<400>  7320
augucaucag gagcacacgg agaagaagga ucagcaagaa uguggaaaac acuaacauuc       60

uucguagcac uaccaggagu agcaguauca augcuaaacg uauaccuaaa aucacaccac      120

ggagaacacg aaagaccaga auucauagca uacccacacc uaagaauaag aacaaaacca      180

uucccauggg gagacggaaa ccacacacua uuccacaacc cacacguaaa cccacuacca      240

acaggauacg aagacgaaua a                                                261


<210>  7321
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FasL__Homo_sapiens__P48023

<400>  7321

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  7322
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FasL__Homo_sapiens__AAC50071

<400>  7322
augcagcagc ccuucaauua cccauauccc cagaucuacu ggguggacag cagugccagc       60

ucucccuggg ccccuccagg cacaguucuu cccuguccaa ccucugugcc cagaaggccu      120

ggucaaagga ggccaccacc accaccgcca ccgccaccac uaccaccucc gccgccgccg      180

ccaccacugc cuccacuacc gcugccaccc cugaagaaga gagggaacca cagcacaggc      240

cugugucucc uugugauguu uuucaugguu cugguugccu ugguaggauu gggccugggg      300

auguuucagc ucuuccaccu acagaaggag cuggcagaac uccgagaguc uaccagccag      360

augcacacag caucaucuuu ggagaagcaa auaggccacc ccaguccacc cccugaaaaa      420

aaggagcuga ggaaaguggc ccauuuaaca ggcaagucca acucaagguc caugccucug      480

gaaugggaag acaccuaugg aauuguccug cuuucuggag ugaaguauaa gaaggguggc      540

cuugugauca augaaacugg gcuguacuuu guauauucca aaguauacuu ccggggucaa      600

ucuugcaaca accugccccu gagccacaag gucuacauga ggaacucuaa guauccccag      660

gaucugguga ugauggaggg gaagaugaug agcuacugca cuacugggca gaugugggcc      720

cgcagcagcu accugggggc aguguucaau cuuaccagug cugaucauuu auaugucaac      780

guaucugagc ucucucuggu caauuuugag gaaucucaga cguuuuucgg cuuauauaag      840

cucuaa                                                                 846


<210>  7323
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FasL__Homo_sapiens__AAC50071

<400>  7323
augcagcagc ccuucaacua cccguacccc cagaucuacu ggguggacag cuccgccagc       60

ucccccuggg cccccccggg caccguccug cccugcccca ccagcgugcc ccgccggccg      120

gggcagcgcc ggcccccccc cccgcccccc cccccgcccc uccccccccc gccccccccc      180

ccgccccugc ccccccugcc gcuccccccc cugaagaagc gcggcaacca cuccacgggg      240

cugugccucc uggugauguu cuucaugguc cugguggcgc ucgugggccu ggggcugggc      300

auguuccagc ucuuccaccu gcagaaggag cuggccgagc uccgggagag caccucccag      360

augcacaccg ccagcucccu ggagaagcag aucggccacc cgagcccccc ccccgagaag      420

aaggagcugc gcaaggucgc ccaccucacc gggaagucca acagccgguc caugccgcug      480

gagugggagg acacguacgg caucgugcug cucagcgggg ugaaguacaa gaagggcggg      540

cuggucauca acgagaccgg ccuguacuuc guguacucca agguguacuu ccgcggccag      600

agcugcaaca accucccccu gucccacaag gucuacaugc ggaacagcaa guacccccag      660

gaccugguga ugauggaggg gaagaugaug uccuacugca ccaccggcca gaugugggcc      720

cgcagcagcu accucggggc gguguucaac cugacguccg ccgaccaccu guacgucaac      780

gugagcgagc ucucccuggu gaacuucgag gagagccaga ccuucuucgg ccuguacaag      840

cucuga                                                                 846


<210>  7324
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FasL__Homo_sapiens__AAC50071

<400>  7324
augcagcagc ccuucaacua ccccuacccc cagaucuacu gggucgacuc cuccgccucc       60

ucccccuggg ccccccccgg caccguccuc cccugcccca ccuccguccc ccgccgcccc      120

ggccagcgcc gccccccccc cccccccccc cccccccccc uccccccccc cccccccccc      180

cccccccucc ccccccuccc ccuccccccc cucaagaagc gcggcaacca cuccaccggc      240

cucugccucc ucgucauguu cuucaugguc cucgucgccc ucgucggccu cggccucggc      300

auguuccagc ucuuccaccu ccagaaggag cucgccgagc uccgcgaguc caccucccag      360

augcacaccg ccuccucccu cgagaagcag aucggccacc ccuccccccc ccccgagaag      420

aaggagcucc gcaaggucgc ccaccucacc ggcaagucca acucccgcuc caugccccuc      480

gagugggagg acaccuacgg caucguccuc cucuccggcg ucaaguacaa gaagggcggc      540

cucgucauca acgagaccgg ccucuacuuc gucuacucca aggucuacuu ccgcggccag      600

uccugcaaca accucccccu cucccacaag gucuacaugc gcaacuccaa guacccccag      660

gaccucguca ugauggaggg caagaugaug uccuacugca ccaccggcca gaugugggcc      720

cgcuccuccu accucggcgc cgucuucaac cucaccuccg ccgaccaccu cuacgucaac      780

gucuccgagc ucucccucgu caacuucgag gagucccaga ccuucuucgg ccucuacaag      840

cucuga                                                                 846


<210>  7325
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FasL__Homo_sapiens__AAC50071

<400>  7325
augcagcaac ccuucaacua cccuuaucca cagaucuacu ggguggacag cuccgccucu       60

ucaccguggg cucccccugg caccguccug ccaugcccca caaguguucc uagaaggcca      120

gggcagcggc gacccccucc accgcccccu ccacccccuc ucccaccccc gccuccccca      180

ccuccccuuc caccccugcc uuugccaccg uuaaagaaac gcggaaauca cagcacuggu      240

cugugucuac ucgugauguu uuucauggua cugguggcac uugucggccu gggguuggga      300

auguuucaac ucuuccaucu gcagaaggag cuggccgaac uccgugaguc cacgucucag      360

augcacaccg cgucgucauu agaaaaacag auuggccauc ccagcccucc acccgagaag      420

aaagaacuga gaaagguggc ucaccuuaca gguaagagua acuccagguc uaugccuuug      480

gagugggagg auacuuaugg gauaguucug cuaagcggag ugaaauacaa gaaaggcggc      540

cucgucauca augaaaccgg gcuguauuuu guguacucca agguauauuu ccggggacag      600

ucaugcaaca aucuuccacu gagucauaaa guuuacaugc gcaacagcaa guacccccaa      660

gacuugguga ugauggaggg uaagaugaug ucuuauugua caaccggcca gaugugggcc      720

agauccucau accucggggc agucuuuaau cugacuagcg ccgaucacuu auaugugaac      780

gugagugaac ugucucucgu caauuucgag gagucccaga cauuuuucgg acuuuacaaa      840

cuguga                                                                 846


<210>  7326
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FasL__Homo_sapiens__AAC50071

<400>  7326
augcagcagc ccuucaacua ccccuacccc cagaucuacu ggguggacag cagcgccagc       60

agccccuggg ccccccccgg caccgugcug cccugcccca ccagcgugcc cagaagaccc      120

ggccagagaa gacccccccc cccccccccc cccccccccc ugcccccccc cccccccccc      180

cccccccugc ccccccugcc ccugcccccc cugaagaaga gaggcaacca cagcaccggc      240

cugugccugc uggugauguu cuucauggug cugguggccc uggugggccu gggccugggc      300

auguuccagc uguuccaccu gcagaaggag cuggccgagc ugagagagag caccagccag      360

augcacaccg ccagcagccu ggagaagcag aucggccacc ccagcccccc ccccgagaag      420

aaggagcuga gaaagguggc ccaccugacc ggcaagagca acagcagaag caugccccug      480

gagugggagg acaccuacgg caucgugcug cugagcggcg ugaaguacaa gaagggcggc      540

cuggugauca acgagaccgg ccuguacuuc guguacagca agguguacuu cagaggccag      600

agcugcaaca accugccccu gagccacaag guguacauga gaaacagcaa guacccccag      660

gaccugguga ugauggaggg caagaugaug agcuacugca ccaccggcca gaugugggcc      720

agaagcagcu accugggcgc cguguucaac cugaccagcg ccgaccaccu guacgugaac      780

gugagcgagc ugagccuggu gaacuucgag gagagccaga ccuucuucgg ccuguacaag      840

cuguga                                                                 846


<210>  7327
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FasL__Homo_sapiens__AAC50071

<400>  7327
augcagcaac ccuucaacua cccuuauccg cagaucuacu ggguggacag cuccgccucu       60

agccccuggg cuccucccgg caccguccug ccuugcccca cauccguucc uagacggccg      120

gggcagcgca gacccccucc cccucccccg ccucccccuc ugcccccucc cccgcccccu      180

cccccucugc ccccgcuucc ucugcccccu cucaagaaac ggggaaauca cucuacgggc      240

cugugucuuc uggugauguu uuucauggug cucgucgccc ugguggggcu cggacucggc      300

auguuucagc uguuccaucu ucaaaaggag cuggcggaac uccgcgagag caccucccag      360

augcacacag cuucuagccu ggaaaaacag auugggcauc ccuccccucc cccggagaag      420

aaagaacuua gaaagguugc ccaccugacc ggaaagagca acucucgguc caugccucuc      480

gagugggagg auacauaugg caucgugcug cugagcggcg ucaaauacaa gaaaggggga      540

cucgugauua augaaaccgg ccuguauuuu guuuacucua agguguauuu ccgcgggcag      600

uccugcaaca aucuuccccu gagccauaaa gucuacauga gaaacucuaa guacccccaa      660

gaccucguga ugauggaggg aaagaugaug uccuauugua caaccggcca gaugugggcc      720

cggagcuccu accugggggc uguguuuaau cuuacgucug ccgaucaccu guaugucaac      780

guuagcgaac ucucccuggu gaauuucgag gagagccaga ccuuuuucgg acuguacaaa      840

cucuga                                                                 846


<210>  7328
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       FasL__Homo_sapiens__AAC50071

<400>  7328
augcaacaac cauucaacua cccauaucca caaauauacu ggguagacuc uucagcauca       60

ucaccauggg caccaccagg aacaguacuc ccuugcccaa caucuguacc aagaagacca      120

ggacaaagaa gacccccacc cccaccacca ccaccaccuc uuccaccccc cccaccacca      180

ccacccuuac caccacuacc ccuaccacca uuaaaaaaaa gagguaacca cuccacaggc      240

cuaugcuuac uaguaauguu cuucauggua cuagucgccc uuguaggacu aggacucgga      300

auguuucaau uauuccacuu acaaaaagaa cuagcagaac uaagagaauc uacaucacaa      360

augcacaccg ccucaucacu agaaaaacaa auuggacacc caucaccacc accagaaaaa      420

aaagaacuca gaaaagucgc acacuuaaca ggaaaaucaa acuccagauc aaugccacua      480

gaaugggaag acacauacgg aauaguacua cuuucaggag uaaaauacaa aaaaggagga      540

cuaguaauaa acgaaacagg auuauacuuc guauacucaa aaguauacuu ucgaggacaa      600

ucaugcaaca accuaccacu aucacacaaa guauacauga gaaacucaaa auacccacaa      660

gaccuaguaa ugauggaagg aaaaaugaug ucauauugca caacaggaca aaugugggca      720

agaucaucuu accuaggagc agucuucaac uuaacaucag cugaccaccu auacguaaac      780

guauccgaac uaucauuagu aaacuucgaa gaaucacaaa cuuucuucgg acucuacaaa      840

cuauaa                                                                 846


<210>  7329
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__J3KQ52

<400>  7329

Met Gln Thr Phe Pro Ser Gly Glu Ile Ile Gly Gly His Glu Ala Lys 
1               5                   10                  15      


Pro His Ser Arg Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys 
            20                  25                  30          


Ser Leu Lys Arg Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu 
        35                  40                  45              


Thr Ala Ala His Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala 
    50                  55                  60                  


His Asn Ile Lys Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys 
65                  70                  75                  80  


Arg Pro Ile Pro His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp 
                85                  90                  95      


Ile Met Leu Leu Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val 
            100                 105                 110         


Gln Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln 
        115                 120                 125             


Thr Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His 
    130                 135                 140                 


Ser His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys 
145                 150                 155                 160 


Cys Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys 
                165                 170                 175     


Val Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly 
        195                 200                 205             


Arg Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe 
    210                 215                 220                 


Val His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
225                 230                 235 


<210>  7330
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__EAW66003

<400>  7330
augcagacuu uuccuucagg ggagaucauc gggggacaug aggccaagcc ccacucccgc       60

cccuacaugg cuuaucuuau gaucugggau cagaagucuc ugaagaggug cgguggcuuc      120

cugauacgag acgacuucgu gcugacagcu gcucacuguu ggggaagcuc cauaaauguc      180

accuuggggg cccacaauau caaagaacag gagccgaccc agcaguuuau cccugugaaa      240

agacccaucc cccauccagc cuauaauccu aagaacuucu ccaacgacau caugcuacug      300

cagcuggaga gaaaggccaa gcggaccaga gcugugcagc cccucaggcu accuagcaac      360

aaggcccagg ugaagccagg gcagacaugc aguguggccg gcugggggca gacggccccc      420

cugggaaaac acucacacac acuacaagag gugaagauga cagugcagga agaucgaaag      480

ugcgaaucug acuuacgcca uuauuacgac aguaccauug aguugugcgu gggggaccca      540

gagauuaaaa agacuuccuu uaagggggac ucuggaggcc cucuugugug uaacaaggug      600

gcccagggca uugucuccua uggacgaaac aauggcaugc cuccacgagc cugcaccaaa      660

gucucaagcu uuguacacug gauaaagaaa accaugaaac gcuacuaa                   708


<210>  7331
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7331
augcagaccu uccccagcgg cgagaucauc gggggccacg aggccaagcc ccacucccgc       60

cccuacaugg ccuaccugau gaucugggac cagaaguccc ucaagcggug cgggggcuuc      120

cugauccgcg acgacuucgu gcugaccgcg gcccacugcu gggggagcag caucaacguc      180

acgcucggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgugaag      240

cggccgaucc cccaccccgc cuacaacccc aagaacuucu ccaacgacau caugcugcug      300

cagcucgagc gcaaggccaa gcggacccgc gcggugcagc cgcugcggcu gcccagcaac      360

aaggcccagg ucaagcccgg ccagaccugc uccguggccg gguggggcca gacggcgccc      420

cucgggaagc acagccacac ccugcaggag gugaagauga ccguccagga ggaccgcaag      480

ugcgaguccg accugcggca cuacuacgac agcaccaucg agcucugcgu gggcgacccg      540

gagaucaaga agacguccuu caagggggac agcggcggcc cccuggugug caacaagguc      600

gcccagggga ucguguccua cggccgcaac aacgggaugc cgccccgggc cugcaccaag      660

gugagcuccu ucguccacug gaucaagaag accaugaagc gcuacuga                   708


<210>  7332
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7332
augcagaccu uccccuccgg cgagaucauc ggcggccacg aggccaagcc ccacucccgc       60

cccuacaugg ccuaccucau gaucugggac cagaaguccc ucaagcgcug cggcggcuuc      120

cucauccgcg acgacuucgu ccucaccgcc gcccacugcu ggggcuccuc caucaacguc      180

acccucggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgucaag      240

cgccccaucc cccaccccgc cuacaacccc aagaacuucu ccaacgacau caugcuccuc      300

cagcucgagc gcaaggccaa gcgcacccgc gccguccagc cccuccgccu ccccuccaac      360

aaggcccagg ucaagcccgg ccagaccugc uccgucgccg gcuggggcca gaccgccccc      420

cucggcaagc acucccacac ccuccaggag gucaagauga ccguccagga ggaccgcaag      480

ugcgaguccg accuccgcca cuacuacgac uccaccaucg agcucugcgu cggcgacccc      540

gagaucaaga agaccuccuu caagggcgac uccggcggcc cccucgucug caacaagguc      600

gcccagggca ucgucuccua cggccgcaac aacggcaugc ccccccgcgc cugcaccaag      660

gucuccuccu ucguccacug gaucaagaag accaugaagc gcuacuga                   708


<210>  7333
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7333
augcagaccu uccccagcgg cgagaucauu gggggacacg aagccaagcc ucauuccaga       60

ccauacaugg cuuaucugau gauaugggac caaaaaucuc ucaagaggug cgguggcuuu      120

cuuauccggg augacuucgu gcugacagca gcccacuguu gggggucaag uauuaacguc      180

acuuugggag cgcauaauau caaagagcag gaaccgacgc agcaguuuau ucccguuaag      240

cgcccuaucc cacaccccgc uuacaacccu aaaaauuuca gcaacgauau aauguuacug      300

caacuagagc gaaaggccaa gcguaccaga gcagugcagc cacucaggcu gcccuccaau      360

aaagcccagg uaaagccugg ccagacaugc ucuguggcug guugggggca aacugcacca      420

cuuggaaaac auucgcacac ccugcaggaa gucaagauga cagugcagga ggaccggaaa      480

ugugagucag auuugcgcca cuauuacgac agcaccaucg aacucugcgu uggcgauccg      540

gagauuaaga agacaaguuu uaaaggcgac uccgggggac cccuggugug uaacaagguc      600

gcccagggua ucgugucuua uggcagaaau aacgggaugc cuccaagggc uugcacuaaa      660

guaagcuccu ucguucauug gauuaagaaa accaugaagc gguacuga                   708


<210>  7334
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7334
augcagaccu uccccagcgg cgagaucauc ggcggccacg aggccaagcc ccacagcaga       60

cccuacaugg ccuaccugau gaucugggac cagaagagcc ugaagagaug cggcggcuuc      120

cugaucagag acgacuucgu gcugaccgcc gcccacugcu ggggcagcag caucaacgug      180

acccugggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgugaag      240

agacccaucc cccaccccgc cuacaacccc aagaacuuca gcaacgacau caugcugcug      300

cagcuggaga gaaaggccaa gagaaccaga gccgugcagc cccugagacu gcccagcaac      360

aaggcccagg ugaagcccgg ccagaccugc agcguggccg gcuggggcca gaccgccccc      420

cugggcaagc acagccacac ccugcaggag gugaagauga ccgugcagga ggacagaaag      480

ugcgagagcg accugagaca cuacuacgac agcaccaucg agcugugcgu gggcgacccc      540

gagaucaaga agaccagcuu caagggcgac agcggcggcc cccuggugug caacaaggug      600

gcccagggca ucgugagcua cggcagaaac aacggcaugc cccccagagc cugcaccaag      660

gugagcagcu ucgugcacug gaucaagaag accaugaaga gauacuga                   708


<210>  7335
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7335
augcagaccu uccccagcgg cgagaucauu gggggacacg aagccaagcc ucauuccaga       60

ccguacaugg cuuaucugau gaucugggac caaaaaucuc ucaagcggug cggcggguuu      120

cugauucgcg augacuucgu gcuuacagcc gcgcacuguu ggggaagcuc caucaacguc      180

acgcugggcg cucauaauau uaaagagcag gaacccaccc agcaguuuau cccuguuaag      240

agacccaucc cucaccccgc cuacaacccu aaaaauuucu cuaacgauau uaugcuccug      300

caacuugagc ggaaggccaa gcgcacaaga gcugugcagc cgcugcggcu ccccagcaau      360

aaagcccagg ugaagccugg gcagaccugc uccgucgcug gauggggcca aacagcgccc      420

cugggcaaac auucucacac ccugcaggaa gugaagauga caguucagga ggaccgcaaa      480

ugugagagcg aucucagaca cuauuacgac uccaccaucg aacugugcgu gggggauccu      540

gagauuaaga agacgagcuu uaaaggagac ucuggcgggc cccuugucug uaacaaggug      600

gcccagggaa ucguuuccua uggccggaau aacgggaugc cgccucgcgc cugcaccaaa      660

gugagcucuu ucguccauug gauuaagaaa acaaugaaga gauacuga                   708


<210>  7336
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Granzyme_B__Homo_sapiens__EAW66003

<400>  7336
augcaaacau ucccaagugg agaaauaaua ggaggacacg aagcaaaacc acacucacga       60

ccauacaugg cauaccuaau gaucugggac caaaaaucac uaaaacgcug cggaggauuc      120

cuaauaagag acgacuucgu acuaacagca gcacacugcu ggggaucauc aauaaacguc      180

acauuaggcg cccacaacau aaaagaacaa gaaccaacac aacaauucau accaguaaaa      240

agaccaauac cacacccagc auacaaccca aaaaacuuca gcaacgacau cauguuacua      300

caacuagaaa gaaaagcaaa aagaacaaga gcaguacaac cacuaagacu accaucaaac      360

aaagcacaag uaaaaccagg acaaacaugu ucaguagcag gauggggaca aacagcacca      420

uuaggaaaac acucacacac acuacaagaa guaaaaauga caguacaaga agacagaaaa      480

ugcgaaucag aucuaagaca cuacuacgac ucaacaauag aacuaugcgu aggagaccca      540

gaaauaaaaa aaacaagcuu caaaggcgac ucaggcggac cauuaguaug uaacaaagua      600

gcacaaggaa uaguaagcua cggaagaaac aacggaaugc caccaagagc augcacaaaa      660

guaucaucau ucguccacug gauaaaaaaa acaaugaaaa gauacuaa                   708


<210>  7337
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__Q67BC3

<400>  7337

Met Lys Ser Leu Ser Leu Leu His Leu Phe Pro Leu Pro Arg Ala Lys 
1               5                   10                  15      


Arg Glu Gln Gly Gly Asn Asn Ser Ser Ser Asn Gln Gly Ser Leu Pro 
            20                  25                  30          


Glu Lys Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro 
        35                  40                  45              


Arg Ala Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His 
    50                  55                  60                  


Ser Arg Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu 
65                  70                  75                  80  


Lys Arg Cys Gly Gly Phe Leu Ile Gln Asp Asp Phe Val Leu Thr Ala 
                85                  90                  95      


Ala His Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn 
            100                 105                 110         


Ile Lys Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro 
        115                 120                 125             


Ile Pro His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met 
    130                 135                 140                 


Leu Leu Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro 
145                 150                 155                 160 


Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys 
                165                 170                 175     


Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His 
            180                 185                 190         


Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu 
        195                 200                 205             


Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly 
    210                 215                 220                 


Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn 
                245                 250                 255     


Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His 
            260                 265                 270         


Trp Ile Lys Lys Thr Met Lys Arg Tyr 
        275                 280     


<210>  7338
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__AAR23323

<400>  7338
augaagucac ugagccugcu ccaccucuuu ccucucccaa gagcuaaaag agagcaagga       60

ggaaacaaca gcagcuccaa ccagggcagc cuuccugaga agaugcaacc aauccugcuu      120

cugcuggccu uccuccugcu gcccagggca gaugcagggg agaucaucgg gggacaugag      180

gccaagcccc acucccgccc cuacauggcu uaucuuauga ucugggauca gaagucucug      240

aagaggugcg guggcuuccu gauacaagac gacuucgugc ugacagcugc ucacuguugg      300

ggaagcucca uaaaugucac cuugggggcc cacaauauca aagaacagga gccgacccag      360

caguuuaucc cugugaaaag acccaucccc cauccagccu auaauccuaa gaacuucucc      420

aacgacauca ugcuacugca gcuggagaga aaggccaagc ggaccagagc ugugcagccc      480

cucaggcuac cuagcaacaa ggcccaggug aagccagggc agacaugcag uguggccggc      540

ugggggcaga cggccccccu gggaaaacac ucacacacac uacaagaggu gaagaugaca      600

gugcaggaag aucgaaagug cgaaucugac uuacgccauu auuacgacag uaccauugag      660

uugugcgugg gggacccaga gauuaaaaag acuuccuuua agggggacuc uggaggcccu      720

cuugugugua acaagguggc ccagggcauu gucuccuaug gacgaaacaa uggcaugccu      780

ccacgagccu gcaccaaagu cucaagcuuu guacacugga uaaagaaaac caugaaacgc      840

uacuaa                                                                 846


<210>  7339
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7339
augaaguccc ugagccuccu gcaccuguuc ccccuccccc gcgccaagcg ggagcagggc       60

gggaacaaca gcuccagcaa ccagggcucc cugcccgaga agaugcagcc cauccugcuc      120

cugcuggccu uccuccugcu gccccgcgcg gacgccgggg agaucaucgg cgggcacgag      180

gccaagccgc acagccggcc cuacauggcc uaccucauga ucugggacca gaagucccug      240

aagcgcugcg gcggcuuccu gauccaggac gacuucgugc ucaccgccgc gcacugcugg      300

gggagcucca ucaacgucac ccugggcgcc cacaacauca aggagcagga gcccacgcag      360

caguucaucc ccgugaagcg gccgaucccc caccccgccu acaaccccaa gaacuucagc      420

aacgacauca ugcugcucca gcuggagcgc aaggccaagc ggacccgcgc ggugcagccg      480

cugcggcucc ccuccaacaa ggcccagguc aagcccgggc agaccugcag cguggccggc      540

ugggggcaga ccgcgccccu gggcaagcac ucccacacgc ugcaggaggu gaagaugacc      600

guccaggagg accgcaagug cgagagcgac cuccggcacu acuacgacuc caccaucgag      660

cugugcgugg gcgacccgga gaucaagaag accagcuuca agggggacuc cggcgggccc      720

cuggugugca acaaggucgc ccagggcauc gugagcuacg gccgcaacaa cgggaugccg      780

ccccgggccu gcacgaaggu guccagcuuc guccacugga ucaagaagac caugaagcgc      840

uacuga                                                                 846


<210>  7340
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7340
augaaguccc ucucccuccu ccaccucuuc ccccuccccc gcgccaagcg cgagcagggc       60

ggcaacaacu ccuccuccaa ccagggcucc cuccccgaga agaugcagcc cauccuccuc      120

cuccucgccu uccuccuccu cccccgcgcc gacgccggcg agaucaucgg cggccacgag      180

gccaagcccc acucccgccc cuacauggcc uaccucauga ucugggacca gaagucccuc      240

aagcgcugcg gcggcuuccu cauccaggac gacuucgucc ucaccgccgc ccacugcugg      300

ggcuccucca ucaacgucac ccucggcgcc cacaacauca aggagcagga gcccacccag      360

caguucaucc ccgucaagcg ccccaucccc caccccgccu acaaccccaa gaacuucucc      420

aacgacauca ugcuccucca gcucgagcgc aaggccaagc gcacccgcgc cguccagccc      480

cuccgccucc ccuccaacaa ggcccagguc aagcccggcc agaccugcuc cgucgccggc      540

uggggccaga ccgccccccu cggcaagcac ucccacaccc uccaggaggu caagaugacc      600

guccaggagg accgcaagug cgaguccgac cuccgccacu acuacgacuc caccaucgag      660

cucugcgucg gcgaccccga gaucaagaag accuccuuca agggcgacuc cggcggcccc      720

cucgucugca acaaggucgc ccagggcauc gucuccuacg gccgcaacaa cggcaugccc      780

ccccgcgccu gcaccaaggu cuccuccuuc guccacugga ucaagaagac caugaagcgc      840

uacuga                                                                 846


<210>  7341
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7341
augaaaagcc ugucccuccu ucaccuguuc cccuugccua gagccaaaag ggagcagggc       60

gggaacaauu cuucaaguaa ccaagguagc uuaccagaaa agaugcagcc gauccugcua      120

cuccuggcuu uucuucuguu gccccgggca gacgccggag agauuauagg cgggcaugaa      180

gcgaaaccuc acucccgccc auacauggcu uaucucauga ucugggauca gaagucucug      240

aaacgaugcg gaggcuuccu gauucaggac gauuuugugc ucaccgccgc acauuguugg      300

gguucgucaa ucaaugucac auuaggggcc cacaacauua aggagcaaga acccacucag      360

caguucaucc cuguuaagcg uccaauaccc cauccugcuu acaauccaaa gaacuuuagc      420

aaugacauca ugcugcuuca guuggagaga aaggcaaaaa ggacgcgggc cgugcaaccg      480

cugcgccuac ccaguaacaa ggcucaggua aaaccuggac agaccugcuc cguggccggc      540

uggggccaga cagcgccacu cgggaagcac ucucacacuc ugcaagaggu caagaugacc      600

gugcaggaag auagaaaaug ugagagcgac cuuaggcauu auuacgauuc cacaauugaa      660

cugugcguug gagaccccga gaucaagaaa accucauuca agggugauag uggcgggccu      720

uuggugugua auaaagucgc acagggaauu gugagcuaug gccggaacaa ugguaugcca      780

ccccgcgccu gcacuaaggu aucuuccuuu guucacugga ucaaaaagac aaugaagcga      840

uacuga                                                                 846


<210>  7342
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7342
augaagagcc ugagccugcu gcaccuguuc ccccugccca gagccaagag agagcagggc       60

ggcaacaaca gcagcagcaa ccagggcagc cugcccgaga agaugcagcc cauccugcug      120

cugcuggccu uccugcugcu gcccagagcc gacgccggcg agaucaucgg cggccacgag      180

gccaagcccc acagcagacc cuacauggcc uaccugauga ucugggacca gaagagccug      240

aagagaugcg gcggcuuccu gauccaggac gacuucgugc ugaccgccgc ccacugcugg      300

ggcagcagca ucaacgugac ccugggcgcc cacaacauca aggagcagga gcccacccag      360

caguucaucc ccgugaagag acccaucccc caccccgccu acaaccccaa gaacuucagc      420

aacgacauca ugcugcugca gcuggagaga aaggccaaga gaaccagagc cgugcagccc      480

cugagacugc ccagcaacaa ggcccaggug aagcccggcc agaccugcag cguggccggc      540

uggggccaga ccgccccccu gggcaagcac agccacaccc ugcaggaggu gaagaugacc      600

gugcaggagg acagaaagug cgagagcgac cugagacacu acuacgacag caccaucgag      660

cugugcgugg gcgaccccga gaucaagaag accagcuuca agggcgacag cggcggcccc      720

cuggugugca acaagguggc ccagggcauc gugagcuacg gcagaaacaa cggcaugccc      780

cccagagccu gcaccaaggu gagcagcuuc gugcacugga ucaagaagac caugaagaga      840

uacuga                                                                 846


<210>  7343
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7343
augaaaagcc ugucccuccu gcaccuuuuc ccccugccca gagccaagcg ggagcagggc       60

gggaacaauu cuagcuccaa ccaaggaucu cucccggaaa agaugcagcc cauccugcuu      120

cugcucgcuu uucugcugcu cccucgcgcc gacgcgggcg agauuaucgg gggacaugaa      180

gcuaaacccc acagcagacc uuacauggcc uaucugauga uuugggauca gaagucccuu      240

aaacggugcg gcggguuccu gauccaggac gauuuugugc ucaccgccgc ucauuguugg      300

ggaucuagca uuaaugucac acugggcgcc cacaacauca aggagcaaga acccacgcag      360

caguucaucc cuguuaagcg cccgauuccc cauccugcuu acaaucccaa aaacuuuucc      420

aaugacauca ugcuucugca gcucgagaga aaggccaaac ggacccgcgc ggugcaaccu      480

cugagacugc ccagcaacaa ggcccaggug aaaccgggcc agacaugcuc ugucgcuggg      540

uggggacaga ccgccccucu cggcaagcac ucccacacac ugcaagaggu gaagaugacc      600

guucaggaag aucggaaaug ugagagcgac cuucgccauu auuacgauuc uacaauugaa      660

cugugcgugg gggaccccga gaucaagaaa accuccuuca agggagauag cggcgggccu      720

cucgucugua auaaaguggc ucagggaauu guuucuuaug gcagaaacaa uggcaugccu      780

ccccgggccu gcacgaaggu guccagcuuu guccacugga ucaaaaagac caugaagcgc      840

uacuga                                                                 846


<210>  7344
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Granzyme_B__Homo_sapiens__AAR23323

<400>  7344
augaaaucac uaagccuacu ccacuuauuc ccacuaccac gagcaaaaag agaacaagga       60

ggaaacaacu caucuucuaa ccaaggauca uuaccagaaa aaaugcaacc aauacuauua      120

cuacucgcau ucuuacuacu accaagagca gacgccggag aaauaauagg aggacacgaa      180

gcaaaaccac acucaagacc auacauggca uacuuaauga uaugggacca aaaaucacua      240

aaaagaugug gugguuuucu gauacaagac gacuucguac uaacagcagc acacugcugg      300

gguagcucaa uaaacguaac acuaggagca cacaacauaa aagaacaaga accaacacaa      360

caauucauac caguaaaaag accaauacca cacccagcau auaacccaaa aaauuucuca      420

aacgacauaa uguuacuaca acuagaacga aaagcaaaaa gaacacgagc aguacaacca      480

cuaagacuac caucaaacaa agcacaagua aaaccaggac aaacaugcuc aguagcagga      540

uggggacaaa cugcaccacu aggaaaacac ucacacacac uacaagaagu aaaaaugaca      600

guacaagaag acagaaaaug cgaaucagac cuaagacacu auuacgacuc aacaauagaa      660

cucugugucg gagaccccga aauaaaaaaa acaucauuca aaggagacuc aggaggacca      720

cuagucugca acaaaguagc acaaggaaua guaaguuacg gaagaaacaa cggaaugcca      780

ccaagagcau gcacaaaagu aucaucauuu guacacugga uaaaaaaaac aaugaaaaga      840

uacuaa                                                                 846


<210>  7345
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__Q6XGZ2

<400>  7345

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu 
            20                  25                  30          


Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser 
        35                  40                  45              


Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr 
    50                  55                  60                  


Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser 
65                  70                  75                  80  


Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp 
                85                  90                  95      


Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu 
            100                 105                 110         


Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn 
        115                 120                 125             


Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp 
    130                 135                 140                 


Ile Lys Lys Thr Met Lys Arg Tyr 
145                 150         


<210>  7346
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__AAP70246

<400>  7346
augcaaccaa uccugcuucu gcuggccuuc cuccugcugc ccagggcaga ucagcuggag       60

agaaaggcca agcggaccag agcugugcag ccccucaggc uaccuagcaa caaggcccag      120

gugaagccag ggcagacaug caguguggcc ggcugggggc agacggcccc ccugggaaaa      180

cacucacaca cacuacaaga ggugaagaug acagugcagg aagaucgaaa gugcgaaucu      240

gacuuacgcc auuauuacga caguaccauu gaguugugcg ugggggaccc agagauuaaa      300

aagacuuccu uuaaggggga cucuggaggc ccucuugugu guaacaaggu ggcccagggc      360

auugucuccu auggacgaaa caauggcaug ccuccacgag ccugcaccaa agucucaagc      420

uuuguacacu ggauaaagaa aaccaugaaa cgcuacuaa                             459


<210>  7347
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7347
augcagccca uccugcuccu gcuggccuuc cuccugcugc cgcgcgccga ccagcucgag       60

cggaaggcga agcgcacccg ggccgugcag ccccugcgcc ugcccagcaa caaggcccag      120

gucaagcccg gccagaccug cuccguggcc ggguggggcc agacggcccc gcucgggaag      180

cacagccaca cccugcagga ggugaagaug accguccagg aggaccggaa gugcgagucc      240

gaccugcgcc acuacuacga cagcaccauc gagcucugcg ugggcgaccc cgagaucaag      300

aagacguccu ucaaggggga cagcggcggc ccccuggugu gcaacaaggu cgcgcagggg      360

aucguguccu acggccggaa caacgggaug cccccgcgcg ccugcaccaa ggugagcucc      420

uucguccacu ggaucaagaa gaccaugaag cgguacuga                             459


<210>  7348
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7348
augcagccca uccuccuccu ccucgccuuc cuccuccucc cccgcgccga ccagcucgag       60

cgcaaggcca agcgcacccg cgccguccag ccccuccgcc uccccuccaa caaggcccag      120

gucaagcccg gccagaccug cuccgucgcc ggcuggggcc agaccgcccc ccucggcaag      180

cacucccaca cccuccagga ggucaagaug accguccagg aggaccgcaa gugcgagucc      240

gaccuccgcc acuacuacga cuccaccauc gagcucugcg ucggcgaccc cgagaucaag      300

aagaccuccu ucaagggcga cuccggcggc ccccucgucu gcaacaaggu cgcccagggc      360

aucgucuccu acggccgcaa caacggcaug cccccccgcg ccugcaccaa ggucuccucc      420

uucguccacu ggaucaagaa gaccaugaag cgcuacuga                             459


<210>  7349
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7349
augcagccca uccugcuccu ucuggccuuc uuguuacugc cuagagcuga ccaacuagag       60

aggaaggcaa aacggacccg cgccgugcag ccacuccgac ugccgagcaa caaggcgcag      120

gucaaacccg gccagacaug cuccguugcu ggguggggac aaacugcccc ucuugguaag      180

cacucucaua cgcugcagga agugaaaaug accguacagg aggaucguaa gugugaauca      240

gacuugagac acuacuauga uaguacaauu gagcucugcg ugggcgaccc agaaauaaag      300

aaaacuagcu uuaaggggga uuccggaggc ccccuggucu guaauaaagu ggcacagggu      360

aucguuucuu acgggaggaa caauggaaug ccuccacggg ccugcaccaa ggugucguca      420

uucguccauu ggauuaaaaa gacaaugaag cgcuauuga                             459


<210>  7350
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7350
augcagccca uccugcugcu gcuggccuuc cugcugcugc ccagagccga ccagcuggag       60

agaaaggcca agagaaccag agccgugcag ccccugagac ugcccagcaa caaggcccag      120

gugaagcccg gccagaccug cagcguggcc ggcuggggcc agaccgcccc ccugggcaag      180

cacagccaca cccugcagga ggugaagaug accgugcagg aggacagaaa gugcgagagc      240

gaccugagac acuacuacga cagcaccauc gagcugugcg ugggcgaccc cgagaucaag      300

aagaccagcu ucaagggcga cagcggcggc ccccuggugu gcaacaaggu ggcccagggc      360

aucgugagcu acggcagaaa caacggcaug ccccccagag ccugcaccaa ggugagcagc      420

uucgugcacu ggaucaagaa gaccaugaag agauacuga                             459


<210>  7351
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7351
augcagccca uccugcuccu gcuugccuuc cugcuccugc cuagagcuga ccaacuugag       60

cggaaggcca aacgcaccag agcggugcag ccgcugcggc uccccagcaa caaggcucag      120

gucaaaccug gccagacaug cuccguugcc ggguggggac aaacggcucc ccugggcaag      180

cacucucaua cccugcagga agugaaaaug acagugcagg aggaucgcaa gugugaaagc      240

gaccucagac acuacuauga uuccaccauu gagcugugcg ucggggaccc ugaaaucaag      300

aaaacaucuu uuaagggaga uagcggcggg ccccuugugu guaauaaagu ugcccaggga      360

auuguguccu acggccggaa caauggcaug ccuccgcgcg ccugcaccaa ggucucuagc      420

uucgugcauu ggaucaaaaa gacaaugaag agauauuga                             459


<210>  7352
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Granzyme_B__Homo_sapiens__AAP70246

<400>  7352
augcaaccaa uacuacuacu acuagcauuc cuacuauuac caagagcaga ccaacuagaa       60

cgaaaagcaa aaagaacaag agcaguacaa ccacuaagac uaccaucaaa caaagcacaa      120

guaaaaccag gacaaacaug cucaguagca ggauggggac aaacagcacc acuaggaaaa      180

cacucacaca cauuacaaga aguaaaaaug acaguacaag aagacagaaa augcgaauca      240

gaccuaagac acuacuacga cucaacaaua gaacuaugcg uaggagaccc agaaauaaaa      300

aaaacaagcu ucaaaggaga cucaggagga ccauuaguau gcaacaaagu agcacaagga      360

auaguaagcu acggaagaaa caacggaaug ccaccaagag caugcacaaa aguaagcuca      420

uucguacacu ggauaaaaaa aacaaugaaa agauacuaa                             459


<210>  7353
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__Q6XGZ3

<400>  7353

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln 
65                  70                  75                  80  


Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr 
                85                  90                  95      


Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser 
            100                 105                 110         


His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys 
        115                 120                 125             


Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val 
    130                 135                 140                 


Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly 
145                 150                 155                 160 


Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg 
                165                 170                 175     


Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val 
            180                 185                 190         


His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
        195                 200         


<210>  7354
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__AAP70245

<400>  7354
augcaaccaa uccugcuucu gcuggccuuc cuccugcugc ccagggcaga ugcaggggag       60

aucaucgggg gacaugaggc caagccccac ucccgccccu acauggcuua ucuuaugauc      120

ugggaucaga agucucugaa gaggugcggu ggcuuccuga uacgagacga cuucgugcug      180

acagcugcuc acuguugggg aagccuggag agaaaggcca agcggaccag agcugugcag      240

ccccucaggc uaccuagcaa caaggcccag gugaagccag ggcagacaug caguguggcc      300

ggcugggggc agacggcccc ccugggaaaa cacucacaca cacuacaaga ggugaagaug      360

acagugcagg aagaucgaaa gugcgaaucu gacuuacgcc auuauuacga caguaccauu      420

gaguugugcg ugggggaccc agagauuaaa aagacuuccu uuaaggggga cucuggaggc      480

ccucuugugu guaacaaggu ggcccagggc auugucuccu auggacgaaa caauggcaug      540

ccuccacgag ccugcaccaa agucucaagc uuuguacacu ggauaaagaa aaccaugaaa      600

cgcuacuaa                                                              609


<210>  7355
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7355
augcagccca uccugcuccu gcuggccuuc cuccugcugc cccgcgccga cgcgggcgag       60

aucaucgggg gccacgaggc caagccccac agccggcccu acauggccua ccucaugauc      120

ugggaccaga agucccugaa gcgcugcggg ggcuuccuga uccgggacga cuucgugcuc      180

accgccgccc acugcugggg gagccuggag cgcaaggcga agcggacccg cgccguccag      240

ccccugcggc ucccguccaa caaggcccag gugaagcccg gccagacgug cagcguggcc      300

ggcugggggc agaccgcgcc ccugggcaag cacucccaca cccugcagga ggucaagaug      360

accgugcagg aggaccgcaa gugcgagagc gaccuccggc acuacuacga cuccacgauc      420

gagcugugcg ugggggaccc cgagaucaag aagaccagcu ucaagggcga cuccgggggc      480

ccgcuggucu gcaacaaggu ggcccagggc aucgugagcu acgggcgcaa caacggcaug      540

ccgccccggg ccugcaccaa ggucuccagc uucgugcacu ggaucaagaa gaccaugaag      600

cgcuacuga                                                              609


<210>  7356
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7356
augcagccca uccuccuccu ccucgccuuc cuccuccucc cccgcgccga cgccggcgag       60

aucaucggcg gccacgaggc caagccccac ucccgccccu acauggccua ccucaugauc      120

ugggaccaga agucccucaa gcgcugcggc ggcuuccuca uccgcgacga cuucguccuc      180

accgccgccc acugcugggg cucccucgag cgcaaggcca agcgcacccg cgccguccag      240

ccccuccgcc uccccuccaa caaggcccag gucaagcccg gccagaccug cuccgucgcc      300

ggcuggggcc agaccgcccc ccucggcaag cacucccaca cccuccagga ggucaagaug      360

accguccagg aggaccgcaa gugcgagucc gaccuccgcc acuacuacga cuccaccauc      420

gagcucugcg ucggcgaccc cgagaucaag aagaccuccu ucaagggcga cuccggcggc      480

ccccucgucu gcaacaaggu cgcccagggc aucgucuccu acggccgcaa caacggcaug      540

cccccccgcg ccugcaccaa ggucuccucc uucguccacu ggaucaagaa gaccaugaag      600

cgcuacuga                                                              609


<210>  7357
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7357
augcagccca uacugcuccu ucuggccuuc uuguuacugc cuagagcuga cgcaggcgag       60

auuauagggg gacacgaagc caagccacau agcaggccgu acauggcgua ucuaaugauc      120

ugggaucaaa aaucccucaa gcggugcggu ggcuuucuga uucgcgacga uuucgugcuu      180

accgcugccc acuguugggg gucucuggag cgaaaagcaa agcguacaag agccguccag      240

cccuugaggc ucccuucaaa caaagcucag guuaagccag gacagacuug caguguggca      300

ggcugggguc aaacggcucc ccuggggaag cauagccaca cccugcagga aguaaaaaug      360

acagugcagg aggaccggaa gugugaaucc gaucuccgcc auuacuauga cucuacuauc      420

gaguuaugcg ucggagaucc ugagauuaaa aagaccucgu uuaaaggcga cucaggcggg      480

ccacuggugu guaauaaggu ugcccaggga aucgugagcu acgguagaaa caauggcaug      540

cccccuaggg ccugcacaaa ggucaguucc uucgugcacu ggaucaaaaa gaccaugaaa      600

cgguauuga                                                              609


<210>  7358
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7358
augcagccca uccugcugcu gcuggccuuc cugcugcugc ccagagccga cgccggcgag       60

aucaucggcg gccacgaggc caagccccac agcagacccu acauggccua ccugaugauc      120

ugggaccaga agagccugaa gagaugcggc ggcuuccuga ucagagacga cuucgugcug      180

accgccgccc acugcugggg cagccuggag agaaaggcca agagaaccag agccgugcag      240

ccccugagac ugcccagcaa caaggcccag gugaagcccg gccagaccug cagcguggcc      300

ggcuggggcc agaccgcccc ccugggcaag cacagccaca cccugcagga ggugaagaug      360

accgugcagg aggacagaaa gugcgagagc gaccugagac acuacuacga cagcaccauc      420

gagcugugcg ugggcgaccc cgagaucaag aagaccagcu ucaagggcga cagcggcggc      480

ccccuggugu gcaacaaggu ggcccagggc aucgugagcu acggcagaaa caacggcaug      540

ccccccagag ccugcaccaa ggugagcagc uucgugcacu ggaucaagaa gaccaugaag      600

agauacuga                                                              609


<210>  7359
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7359
augcagccca uccugcuccu gcuugccuuc cugcuccugc cuagagcuga cgccggcgag       60

auuaucgggg gacacgaagc gaagccgcau agccggcccu acauggcuua ucuuaugauu      120

ugggaucaaa aaucccugaa gcgcugcggc ggguuucuca ucagagacga uuucgugcug      180

accgccgccc acuguugggg aucucuggag cggaaagcua agcgcacaag agccguccag      240

ccucuccggc ugcccagcaa caaagcucag guuaagccug gccagacgug cuccguggcc      300

ggguggggac aaaccgcgcc ccuuggcaag cauucucaca cacugcagga agugaaaaug      360

accguccagg aggaccgcaa gugugaaagc gaucucagac auuacuauga cuccacaauu      420

gagcugugcg ugggcgaucc ugagaucaaa aagaccucuu uuaaagggga cagcggaggc      480

ccgcuuguuu guaauaaggu ggcccagggg aucgucuccu acggacggaa caauggcaug      540

cccccucgcg cuugcacaaa ggugagcucu uucguucacu ggauuaaaaa gaccaugaaa      600

agauauuga                                                              609


<210>  7360
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Granzyme_B__Homo_sapiens__AAP70245

<400>  7360
augcaaccaa uauuauuacu acuagcauuc cuauuacuac caagagcaga cgcaggagaa       60

auaauaggcg gacacgaagc aaaaccccau agcagaccau auauggcaua cuuaaugaua      120

ugggaccaaa aaagccuaaa aagaugcgga ggauuuuuaa uaagagauga cuuuguauua      180

acagcagcac acuguugggg aucacucgaa agaaaagcaa aaagaacaag agcaguccaa      240

ccacuaagau uaccaucaaa caaagcacaa guaaaaccag gacaaacaug cucaguagca      300

ggauggggac aaacagcgcc auuaggaaaa cacucacaca cacuacaaga aguaaaaaug      360

acaguacaag aagacagaaa augugaauca gacuuaagac auuacuauga cucaacaaua      420

gaauuaugcg uaggagaccc agaaauaaaa aaaacaagcu uuaaaggaga cucaggagga      480

ccauuaguau guaacaaagu agcacaagga auaguaagcu acggaagaaa caauggaaug      540

ccaccaagag caugcacaaa aguaagcuca uucguacacu ggauaaaaaa aacaaugaaa      600

agauauuaa                                                              609


<210>  7361
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__Q6XGZ4

<400>  7361

Met Gln Thr Phe Pro Ser Gly Glu Ile Ile Gly Gly His Glu Ala Lys 
1               5                   10                  15      


Pro His Ser Arg Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys 
            20                  25                  30          


Ser Leu Lys Arg Cys Gly Gly Phe Leu Ile Gln Asp Asp Phe Val Leu 
        35                  40                  45              


Thr Ala Ala His Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala 
    50                  55                  60                  


His Asn Ile Lys Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys 
65                  70                  75                  80  


Arg Pro Ile Pro His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp 
                85                  90                  95      


Ile Met Leu Leu Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val 
            100                 105                 110         


Gln Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln 
        115                 120                 125             


Thr Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His 
    130                 135                 140                 


Ser His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys 
145                 150                 155                 160 


Cys Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys 
                165                 170                 175     


Val Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly 
        195                 200                 205             


Arg Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe 
    210                 215                 220                 


Val His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
225                 230                 235 


<210>  7362
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Granzyme_B__Homo_sapiens__AAP70244

<400>  7362
augcagacuu uuccuucagg ggagaucauc gggggacaug aggccaagcc ccacucccgc       60

cccuacaugg cuuaucuuau gaucugggau cagaagucuc ugaagaggug cgguggcuuc      120

cugauacaag acgacuucgu gcugacagcu gcucacuguu ggggaagcuc cauaaauguc      180

accuuggggg cccacaauau caaagaacag gagccgaccc agcaguuuau cccugugaaa      240

agacccaucc cccauccagc cuauaauccu aagaacuucu ccaacgacau caugcuacug      300

cagcuggaga gaaaggccaa gcggaccaga gcugugcagc cccucaggcu accuagcaac      360

aaggcccagg ugaagccagg gcagacaugc aguguggccg gcugggggca gacggccccc      420

cugggaaaac acucacacac acuacaagag gugaagauga cagugcagga agaucgaaag      480

ugcgaaucug acuuacgcca uuauuacgac aguaccauug aguugugcgu gggggaccca      540

gagauuaaaa agacuuccuu uaagggggac ucuggaggcc cucuugugug uaacaaggug      600

gcccagggca uugucuccua uggacgaaac aauggcaugc cuccacgagc cugcaccaaa      660

gucucaagcu uuguacacug gauaaagaaa accaugaaac gcuacuaa                   708


<210>  7363
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7363
augcagaccu uccccagcgg cgagaucauc gggggccacg aggccaagcc ccacucccgc       60

cccuacaugg ccuaccugau gaucugggac cagaaguccc ucaagcggug cgggggcuuc      120

cugauccagg acgacuucgu gcugaccgcg gcccacugcu gggggagcag caucaacguc      180

acgcucggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgugaag      240

cgcccgaucc cccaccccgc cuacaacccc aagaacuucu ccaacgacau caugcugcug      300

cagcucgagc ggaaggccaa gcgcacccgg gcggugcagc cgcugcgccu gcccagcaac      360

aaggcccagg ucaagcccgg ccagaccugc uccguggccg gguggggcca gacggcgccc      420

cucgggaagc acagccacac ccugcaggag gugaagauga ccguccagga ggaccggaag      480

ugcgaguccg accugcgcca cuacuacgac agcaccaucg agcucugcgu gggcgacccg      540

gagaucaaga agacguccuu caagggggac agcggcggcc cccuggugug caacaagguc      600

gcccagggga ucguguccua cggccggaac aacgggaugc cgccccgcgc cugcaccaag      660

gugagcuccu ucguccacug gaucaagaag accaugaagc gguacuga                   708


<210>  7364
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7364
augcagaccu uccccuccgg cgagaucauc ggcggccacg aggccaagcc ccacucccgc       60

cccuacaugg ccuaccucau gaucugggac cagaaguccc ucaagcgcug cggcggcuuc      120

cucauccagg acgacuucgu ccucaccgcc gcccacugcu ggggcuccuc caucaacguc      180

acccucggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgucaag      240

cgccccaucc cccaccccgc cuacaacccc aagaacuucu ccaacgacau caugcuccuc      300

cagcucgagc gcaaggccaa gcgcacccgc gccguccagc cccuccgccu ccccuccaac      360

aaggcccagg ucaagcccgg ccagaccugc uccgucgccg gcuggggcca gaccgccccc      420

cucggcaagc acucccacac ccuccaggag gucaagauga ccguccagga ggaccgcaag      480

ugcgaguccg accuccgcca cuacuacgac uccaccaucg agcucugcgu cggcgacccc      540

gagaucaaga agaccuccuu caagggcgac uccggcggcc cccucgucug caacaagguc      600

gcccagggca ucgucuccua cggccgcaac aacggcaugc ccccccgcgc cugcaccaag      660

gucuccuccu ucguccacug gaucaagaag accaugaagc gcuacuga                   708


<210>  7365
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7365
augcagaccu uccccagcgg cgagaucauu gggggacacg aagccaagcc ucauuccaga       60

ccauacaugg cuuaucugau gauaugggac caaaaaucuc ucaagaggug cgguggcuuu      120

cuuauccagg augacuucgu gcugacagca gcccacuguu gggggucaag uauuaacguc      180

acuuugggag cgcauaauau caaagagcag gaaccgacgc agcaauuuau ucccguuaag      240

cggccuaucc cacaccccgc uuacaacccu aaaaauuuca gcaacgauau aauguuacug      300

cagcuagagc gcaaggccaa gcgaacccgu gcagugcagc cacucagacu gcccuccaau      360

aaagcccagg uaaagccugg ccaaacaugc ucuguggcug guugggggca gacugcacca      420

cuuggaaaac auucgcacac ccugcaggaa gucaagauga cagugcagga ggacaggaaa      480

ugugagucag auuugcggca cuauuacgac agcaccaucg aacucugcgu uggcgauccg      540

gagauuaaga agacaaguuu uaaaggcgac uccgggggac cccuggugug uaacaagguc      600

gcccaaggua ucgugucuua uggccgcaau aacgggaugc cuccaagagc uugcacuaaa      660

guaagcuccu ucguucauug gauuaagaaa accaugaaga gguacuga                   708


<210>  7366
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7366
augcagaccu uccccagcgg cgagaucauc ggcggccacg aggccaagcc ccacagcaga       60

cccuacaugg ccuaccugau gaucugggac cagaagagcc ugaagagaug cggcggcuuc      120

cugauccagg acgacuucgu gcugaccgcc gcccacugcu ggggcagcag caucaacgug      180

acccugggcg cccacaacau caaggagcag gagcccaccc agcaguucau ccccgugaag      240

agacccaucc cccaccccgc cuacaacccc aagaacuuca gcaacgacau caugcugcug      300

cagcuggaga gaaaggccaa gagaaccaga gccgugcagc cccugagacu gcccagcaac      360

aaggcccagg ugaagcccgg ccagaccugc agcguggccg gcuggggcca gaccgccccc      420

cugggcaagc acagccacac ccugcaggag gugaagauga ccgugcagga ggacagaaag      480

ugcgagagcg accugagaca cuacuacgac agcaccaucg agcugugcgu gggcgacccc      540

gagaucaaga agaccagcuu caagggcgac agcggcggcc cccuggugug caacaaggug      600

gcccagggca ucgugagcua cggcagaaac aacggcaugc cccccagagc cugcaccaag      660

gugagcagcu ucgugcacug gaucaagaag accaugaaga gauacuga                   708


<210>  7367
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7367
augcagaccu uccccagcgg cgagaucauu gggggacacg aagccaagcc ucauuccaga       60

ccguacaugg cuuaucugau gaucugggac caaaaaucuc ucaagcggug cggcggguuu      120

cugauucagg augacuucgu gcuuacagcc gcgcacuguu ggggaagcuc caucaacguc      180

acgcugggcg cucauaauau uaaagagcag gaacccaccc agcaauuuau cccuguuaag      240

cgccccaucc cucaccccgc cuacaacccu aaaaauuucu cuaacgauau uaugcuccug      300

cagcuugaga gaaaggccaa gcggacacgc gcugugcagc cgcugagacu ccccagcaau      360

aaagcccagg ugaagccugg gcaaaccugc uccgucgcug gauggggcca gacagcgccc      420

cugggcaaac auucucacac ccugcaggaa gugaagauga caguucagga ggaccggaaa      480

ugugagagcg aucuccgcca cuauuacgac uccaccaucg aacugugcgu gggggauccu      540

gagauuaaga agacgagcuu uaaaggagac ucuggcgggc cccuugucug uaacaaggug      600

gcccaaggaa ucguuuccua uggcagaaau aacgggaugc cgccucgggc cugcaccaaa      660

gugagcucuu ucguccauug gauuaagaaa acaaugaagc gcuacuga                   708


<210>  7368
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Granzyme_B__Homo_sapiens__AAP70244

<400>  7368
augcaaacau ucccaucagg agaaauaaua ggaggacaug aagcaaaacc acacucaaga       60

ccguacaugg cauacuuaau gauaugggau caaaaaucac uaaaaagaug cggaggauuu      120

cuaauccaag acgacuucgu acuaacagca gcucacugcu ggggaucauc aauaaacgua      180

acacuaggag cacacaacau aaaagaacaa gaacccacac aacaauuuau accaguaaaa      240

agaccaaucc cacacccagc auacaaccca aaaaacuucu caaacgacau aauguuauua      300

caauuagaaa gaaaagcaaa aagaacaaga gcaguacaac cauuaagacu accaucaaac      360

aaagcacaag ucaaaccagg acaaacaugc ucaguagcug gauggggaca aacagcacca      420

cuaggaaaac acagucacac acuacaagaa guaaaaauga ccguacaaga agacagaaaa      480

ugcgaaucag accuaagaca cuacuacgac ucaacaauag aacuaugcgu aggagaccca      540

gaaauaaaaa aaacaagcuu caaaggagac agcggagguc cauuaguaug caacaaagua      600

gcucaaggaa uaguaaguua cggaagaaac aacggaaugc cacccagagc augcacaaaa      660

gucucaucau ucguacacug gauaaaaaaa acaaugaaaa gauacuaa                   708


<210>  7369
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TNF__Homo_sapiens__P01375

<400>  7369

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  7370
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TNF__Homo_sapiens__AAA36758

<400>  7370
augagcacug aaagcaugau ccgggacgug gagcuggccg aggaggcgcu ccccaagaag       60

acaggggggc cccagggcuc caggcggugc uuguuccuca gccucuucuc cuuccugauc      120

guggcaggcg ccaccacgcu cuucugccug cugcacuuug gagugaucgg cccccagagg      180

gaagaguucc ccagggaccu cucucuaauc agcccucugg cccaggcagu cagaucaucu      240

ucucgaaccc cgagugacaa gccuguagcc cauguuguag caaacccuca agcugagggg      300

cagcuccagu ggcugaaccg ccgggccaau gcccuccugg ccaauggcgu ggagcugaga      360

gauaaccagc ugguggugcc aucagagggc cuguaccuca ucuacuccca gguccucuuc      420

aagggccaag gcugccccuc cacccaugug cuccucaccc acaccaucag ccgcaucgcc      480

gucuccuacc agaccaaggu caaccuccuc ucugccauca agagccccug ccagagggag      540

accccagagg gggcugaggc caagcccugg uaugagccca ucuaucuggg aggggucuuc      600

cagcuggaga agggugaccg acucagcgcu gagaucaauc ggcccgacua ucucgacuuu      660

gccgagucug ggcaggucua cuuugggauc auugcccugu ga                         702


<210>  7371
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TNF__Homo_sapiens__AAA36758

<400>  7371
augagcaccg aguccaugau ccgcgacgug gagcuggccg aggaggcccu ccccaagaag       60

accggcgggc cgcagggcag ccggcgcugc cuguuccugu cccucuucag cuuccugauc      120

gucgcggggg ccacgacccu guucugccuc cugcacuucg gcgugaucgg gccccagcgg      180

gaggaguucc cccgcgaccu gucccucauc agcccccugg cccaggccgu gcgguccagc      240

ucccgcaccc cgagcgacaa gcccgucgcc cacguggugg cgaaccccca ggccgagggc      300

cagcugcagu ggcucaaccg gcgcgccaac gcccugcugg cgaacggcgu cgagcuccgg      360

gacaaccagc ugguggugcc cuccgagggg cuguaccuca ucuacagcca gguccuguuc      420

aagggccagg ggugcccguc cacccacgug cugcucacgc acaccaucag ccgcaucgcc      480

guguccuacc agaccaaggu caaccugcug agcgccauca agucccccug ccagcgggag      540

acccccgagg gcgccgaggc caagcccugg uacgagccga ucuaccucgg gggcguguuc      600

cagcuggaga agggcgaccg ccugagcgcg gagaucaacc ggcccgacua ccucgacuuc      660

gccgaguccg gccaggugua cuucgggauc aucgcccugu ga                         702


<210>  7372
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TNF__Homo_sapiens__AAA36758

<400>  7372
auguccaccg aguccaugau ccgcgacguc gagcucgccg aggaggcccu ccccaagaag       60

accggcggcc cccagggcuc ccgccgcugc cucuuccucu cccucuucuc cuuccucauc      120

gucgccggcg ccaccacccu cuucugccuc cuccacuucg gcgucaucgg cccccagcgc      180

gaggaguucc cccgcgaccu cucccucauc uccccccucg cccaggccgu ccgcuccucc      240

ucccgcaccc ccuccgacaa gcccgucgcc cacgucgucg ccaaccccca ggccgagggc      300

cagcuccagu ggcucaaccg ccgcgccaac gcccuccucg ccaacggcgu cgagcuccgc      360

gacaaccagc ucgucguccc cuccgagggc cucuaccuca ucuacuccca gguccucuuc      420

aagggccagg gcugccccuc cacccacguc cuccucaccc acaccaucuc ccgcaucgcc      480

gucuccuacc agaccaaggu caaccuccuc uccgccauca agucccccug ccagcgcgag      540

acccccgagg gcgccgaggc caagcccugg uacgagccca ucuaccucgg cggcgucuuc      600

cagcucgaga agggcgaccg ccucuccgcc gagaucaacc gccccgacua ccucgacuuc      660

gccgaguccg gccaggucua cuucggcauc aucgcccucu ga                         702


<210>  7373
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TNF__Homo_sapiens__AAA36758

<400>  7373
augagcaccg aguccaugau cagagacgug gaacuggccg aggaagcucu ccccaagaaa       60

acaggcgggc cucagggauc uaggcggugc cuuuuccugu cauuguuuag uuucuuaauu      120

gucgccggug caacuacgcu guuuugucua cuccacuucg gcguuauagg gccacaacgc      180

gaggaauuuc cgcgagaucu gagccuuauc ucuccccugg cgcaggcugu gcguuccucg      240

ucaagaaccc cuagcgacaa gccaguagcc cauguggucg caaaccccca ggccgaggga      300

caguugcaau ggcucaauag gcgggcuaac gcacugcugg ccaauggcgu ggagcuccgc      360

gauaaccagu uaguugugcc uagugaaggu cuguaccuua uuuauuccca ggucuuguuc      420

aaagggcagg gaugcccauc uacacacgug cugcuaacuc auaccaucag cagaauugcu      480

guauccuacc aaacaaaggu uaaucuccug ucagccauca aaagucccug ucagagggag      540

accccugaag gcgcggaggc aaagccaugg uaugagccga uauaccuugg cgggguguuu      600

cagcuggaaa agggagaccg guugagcgcc gagaucaacc gccccgauua ucucgacuuc      660

gcugaaucug gucaggucua cuuuggcauu aucgcccugu ga                         702


<210>  7374
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TNF__Homo_sapiens__AAA36758

<400>  7374
augagcaccg agagcaugau cagagacgug gagcuggccg aggaggcccu gcccaagaag       60

accggcggcc cccagggcag cagaagaugc cuguuccuga gccuguucag cuuccugauc      120

guggccggcg ccaccacccu guucugccug cugcacuucg gcgugaucgg cccccagaga      180

gaggaguucc ccagagaccu gagccugauc agcccccugg cccaggccgu gagaagcagc      240

agcagaaccc ccagcgacaa gcccguggcc cacguggugg ccaaccccca ggccgagggc      300

cagcugcagu ggcugaacag aagagccaac gcccugcugg ccaacggcgu ggagcugaga      360

gacaaccagc ugguggugcc cagcgagggc cuguaccuga ucuacagcca ggugcuguuc      420

aagggccagg gcugccccag cacccacgug cugcugaccc acaccaucag cagaaucgcc      480

gugagcuacc agaccaaggu gaaccugcug agcgccauca agagccccug ccagagagag      540

acccccgagg gcgccgaggc caagcccugg uacgagccca ucuaccuggg cggcguguuc      600

cagcuggaga agggcgacag acugagcgcc gagaucaaca gacccgacua ccuggacuuc      660

gccgagagcg gccaggugua cuucggcauc aucgcccugu ga                         702


<210>  7375
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TNF__Homo_sapiens__AAA36758

<400>  7375
augagcaccg aguccaugau cagagacgug gaacuggccg aggaagcucu ccccaagaaa       60

acaggcgggc cucagggauc ucggcgcugc cuguuccuua gccuguuuuc cuuccucauu      120

gucgccggcg cgacgacccu guuuugucuu cugcacuucg ggguuaucgg accgcaaaga      180

gaggaauuuc cccgggaucu cucucugauu agcccucugg cucaggccgu gcgcuccucu      240

agcagaacac ccuccgacaa gccuguggcc caugucgugg cuaaccccca ggccgagggc      300

cagcuccaau ggcugaaucg gcgcgcuaac gcccuucugg cgaauggggu ugagcucaga      360

gauaaccagc uggugguccc uagcgaagga cuuuaccuga ucuauucuca gguucucuuc      420

aaaggccagg gcugcccguc cacccacgug cugcugacac auaccauuag ccggaucgcc      480

gugucuuacc aaacaaaggu caaucuccug uccgcuauca aaagccccug ucagcgcgag      540

accccugaag gggccgaggc uaagcccugg uaugagccua uuuaccuugg aggcguguuu      600

cagcuggaaa agggggacag acucucugcc gagaucaacc ggcccgauua ucuggacuuc      660

gcggaauccg gacaggugua cuuuggcauu aucgcccuuu ga                         702


<210>  7376
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TNF__Homo_sapiens__AAA36758

<400>  7376
augucaacag aaucuaugau aagagacguc gaacuagcag aagaagcauu accaaaaaaa       60

accggaggac cacaaggcuc aagaagaugc cuauuccuau cauuauucuc auuccuaaua      120

guagcaggcg caacaacacu auuuugccua uuacauuucg gaguaaucgg accacaaaga      180

gaagaauucc cacgcgaccu aucauuaaua ucuccacuag cacaagccgu uagaucauca      240

ucaagaacac caucagacaa accaguagcc cacgucguag caaaccccca agccgaagga      300

caacuacaau ggcuaaaccg cagagcaaac gcacuauuag ccaacggagu agaauuaaga      360

gacaaccaac uaguaguacc aucagaagga cuauaccuaa uauacucaca aguacuauuc      420

aaaggacaag gcugcccauc aacccacgua cuacuaacac acacaauauc aagaauagca      480

guaucauacc aaacaaaagu aaaccuacua ucagcaauaa aaucaccaug ccaaagagaa      540

acacccgaag gagcagaagc caaaccaugg uacgaaccua uauaccuagg aggaguauuc      600

caauuagaaa aaggagacag acuaucagca gaaauaaaca gaccagauua ccuagauuuc      660

gcagaauccg gacaaguaua cuucggaaua auagcacuau aa                         702


<210>  7377
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TNF__Homo_sapiens__Q5STB3

<400>  7377

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  7378
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TNF__Homo_sapiens__ADV31546

<400>  7378
augagcacug aaagcaugau ccgggacgug gagcuggccg aggaggcgcu ccccaagaag       60

acaggggggc cccagggcuc caggcggugc uuguuccuca gccucuucuc cuuccugauc      120

guggcaggcg ccaccacgcu cuucugccug cugcacuuug gggugaucgg cccccagagg      180

gaagaguucc ccagggaccu cucucuaauc agcccucugg cccaggcagu cagaucaucu      240

ucucgaaccc cgagugacaa gccuguagcc cauguuguag caaacccuca agcugagggg      300

cagcuccagu ggcugaaccg ccgggccaau gcccuccugg ccaauggcgu ggagcugaga      360

gauaaccagu ugguggugcc aucagagggc cuguaccuca ucuacuccca gguccucuuc      420

aagggccaag gcugccccuc cacccaugug cuccucaccc acaccaucag ccgcaucgcc      480

gucuccuacc agaccaaggu caaccuccuc ucugccauca agagccccug ccagagggag      540

accccagagg gggcugaggc caagcccugg uaugagccca ucuaucuggg aggggucuuc      600

cagcuggaga agggugaccg acucagcgcu gagaucaauc ggcccgacua ucucgacuuu      660

gccgagucug ggcaggucua cuuugggauc auugcccugu ga                         702


<210>  7379
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TNF__Homo_sapiens__ADV31546

<400>  7379
augagcaccg aguccaugau ccgcgacgug gagcuggccg aggaggcccu ccccaagaag       60

accggcgggc cgcagggcag ccggcgcugc cuguuccugu cccucuucag cuuccugauc      120

gucgcggggg ccacgacccu guucugccuc cugcacuucg gcgugaucgg gccccagcgg      180

gaggaguucc cccgcgaccu gucccucauc agcccccugg cccaggccgu gcgguccagc      240

ucccgcaccc cgagcgacaa gcccgucgcc cacguggugg cgaaccccca ggccgagggc      300

cagcugcagu ggcucaaccg gcgcgccaac gcccugcugg cgaacggcgu cgagcuccgg      360

gacaaccagc ugguggugcc cuccgagggg cuguaccuca ucuacagcca gguccuguuc      420

aagggccagg ggugcccguc cacccacgug cugcucacgc acaccaucag ccgcaucgcc      480

guguccuacc agaccaaggu caaccugcug agcgccauca agucccccug ccagcgggag      540

acccccgagg gcgccgaggc caagcccugg uacgagccga ucuaccucgg gggcguguuc      600

cagcuggaga agggcgaccg ccugagcgcg gagaucaacc ggcccgacua ccucgacuuc      660

gccgaguccg gccaggugua cuucgggauc aucgcccugu ga                         702


<210>  7380
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TNF__Homo_sapiens__ADV31546

<400>  7380
auguccaccg aguccaugau ccgcgacguc gagcucgccg aggaggcccu ccccaagaag       60

accggcggcc cccagggcuc ccgccgcugc cucuuccucu cccucuucuc cuuccucauc      120

gucgccggcg ccaccacccu cuucugccuc cuccacuucg gcgucaucgg cccccagcgc      180

gaggaguucc cccgcgaccu cucccucauc uccccccucg cccaggccgu ccgcuccucc      240

ucccgcaccc ccuccgacaa gcccgucgcc cacgucgucg ccaaccccca ggccgagggc      300

cagcuccagu ggcucaaccg ccgcgccaac gcccuccucg ccaacggcgu cgagcuccgc      360

gacaaccagc ucgucguccc cuccgagggc cucuaccuca ucuacuccca gguccucuuc      420

aagggccagg gcugccccuc cacccacguc cuccucaccc acaccaucuc ccgcaucgcc      480

gucuccuacc agaccaaggu caaccuccuc uccgccauca agucccccug ccagcgcgag      540

acccccgagg gcgccgaggc caagcccugg uacgagccca ucuaccucgg cggcgucuuc      600

cagcucgaga agggcgaccg ccucuccgcc gagaucaacc gccccgacua ccucgacuuc      660

gccgaguccg gccaggucua cuucggcauc aucgcccucu ga                         702


<210>  7381
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TNF__Homo_sapiens__ADV31546

<400>  7381
augagcaccg aguccaugau cagagacgug gaacuggccg aggaagcucu ccccaagaaa       60

acaggcgggc cucagggauc uaggcggugc cuuuuccugu cauuguuuag uuucuuaauu      120

gucgccggug caacuacgcu guuuugucua cuccacuucg gcguuauagg gccacaacgc      180

gaggaauuuc cgcgagaucu gagccuuauc ucuccccugg cgcaggcugu gcguuccucg      240

ucaagaaccc cuagcgacaa gccaguagcc cauguggucg caaaccccca ggccgaggga      300

caguugcaau ggcucaauag gcgggcuaac gcacugcugg ccaauggcgu ggagcuccgc      360

gauaaccagu uaguugugcc uagugaaggu cuguaccuua uuuauuccca ggucuuguuc      420

aaagggcagg gaugcccauc uacacacgug cugcuaacuc auaccaucag cagaauugcu      480

guauccuacc aaacaaaggu uaaucuccug ucagccauca aaagucccug ucagagggag      540

accccugaag gcgcggaggc aaagccaugg uaugagccga uauaccuugg cgggguguuu      600

cagcuggaaa agggagaccg guugagcgcc gagaucaacc gccccgauua ucucgacuuc      660

gcugaaucug gucaggucua cuuuggcauu aucgcccugu ga                         702


<210>  7382
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TNF__Homo_sapiens__ADV31546

<400>  7382
augagcaccg agagcaugau cagagacgug gagcuggccg aggaggcccu gcccaagaag       60

accggcggcc cccagggcag cagaagaugc cuguuccuga gccuguucag cuuccugauc      120

guggccggcg ccaccacccu guucugccug cugcacuucg gcgugaucgg cccccagaga      180

gaggaguucc ccagagaccu gagccugauc agcccccugg cccaggccgu gagaagcagc      240

agcagaaccc ccagcgacaa gcccguggcc cacguggugg ccaaccccca ggccgagggc      300

cagcugcagu ggcugaacag aagagccaac gcccugcugg ccaacggcgu ggagcugaga      360

gacaaccagc ugguggugcc cagcgagggc cuguaccuga ucuacagcca ggugcuguuc      420

aagggccagg gcugccccag cacccacgug cugcugaccc acaccaucag cagaaucgcc      480

gugagcuacc agaccaaggu gaaccugcug agcgccauca agagccccug ccagagagag      540

acccccgagg gcgccgaggc caagcccugg uacgagccca ucuaccuggg cggcguguuc      600

cagcuggaga agggcgacag acugagcgcc gagaucaaca gacccgacua ccuggacuuc      660

gccgagagcg gccaggugua cuucggcauc aucgcccugu ga                         702


<210>  7383
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TNF__Homo_sapiens__ADV31546

<400>  7383
augagcaccg aguccaugau cagagacgug gaacuggccg aggaagcucu ccccaagaaa       60

acaggcgggc cucagggauc ucggcgcugc cuguuccuua gccuguuuuc cuuccucauu      120

gucgccggcg cgacgacccu guuuugucuu cugcacuucg ggguuaucgg accgcaaaga      180

gaggaauuuc cccgggaucu cucucugauu agcccucugg cucaggccgu gcgcuccucu      240

agcagaacac ccuccgacaa gccuguggcc caugucgugg cuaaccccca ggccgagggc      300

cagcuccaau ggcugaaucg gcgcgcuaac gcccuucugg cgaauggggu ugagcucaga      360

gauaaccagc uggugguccc uagcgaagga cuuuaccuga ucuauucuca gguucucuuc      420

aaaggccagg gcugcccguc cacccacgug cugcugacac auaccauuag ccggaucgcc      480

gugucuuacc aaacaaaggu caaucuccug uccgcuauca aaagccccug ucagcgcgag      540

accccugaag gggccgaggc uaagcccugg uaugagccua uuuaccuugg aggcguguuu      600

cagcuggaaa agggggacag acucucugcc gagaucaacc ggcccgauua ucuggacuuc      660

gcggaauccg gacaggugua cuuuggcauu aucgcccuuu ga                         702


<210>  7384
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TNF__Homo_sapiens__ADV31546

<400>  7384
augucaacag aaucaaugau aagagacgua gaacuagcag aagaagcauu accaaaaaaa       60

acaggaggac cacaaggaag cagacgaugc uuauuccuau cacuauucuc auuuuuaaua      120

guagcaggag caacaacacu auucugccua uuacauuucg gagucauagg accacaaaga      180

gaagaauucc cuagagaccu aucacuaaua ucaccacuag cacaagcagu aagaucauca      240

agcagaacac caucagacaa accaguagcc cacguaguag caaacccaca agcagaagga      300

caacuccaau ggcuaaaccg aagagccaac gcauuacucg caaacggagu agaauuaaga      360

gacaaccaau uaguaguacc aucagaaggc cucuaucuaa uauacucaca aguauuauuc      420

aaaggacaag gauguccauc aacccacgua cuacuaacac acacaauauc aagaauagca      480

guaucauacc aaacaaaagu aaaccuacua agcgcaauaa aaucacccug ccaaagagaa      540

acaccugaag gagccgaagc aaaaccaugg uaugaaccaa uauaccuagg aggaguauuc      600

caauuagaaa aaggagaccg acuauccgca gaaauaaaua gaccagacua ccuagacuuc      660

gcagaaucag gacaaguaua cuucggaaua auagcacuau aa                         702


<210>  7385
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Angiopoietin-2__Homo_sapiens__B2R6E3

<400>  7385

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Gly Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Phe Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     






<210>  7386
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7386
auguggcaga uuguuuucuu uacucugagc ugugaucuug ucuuggccgc agccuauaac       60

aacuuucgga agagcaugga cagcauagga aagaagcaau aucaggucca gcaugggucc      120

ugcagcuaca cuuuccuccu gccagagaug gacaacugcc gcucuuccuc cagccccuac      180

guguccaaug cugugcagag ggacgcgccg cucgaauacg augacucggu gcagaggcug      240

caagugcugg agaacaucau ggaaaacaac acucaguggc uaaugaagcu ugagaauuau      300

auccaggaca acaugaagaa agaaauggua gagauacagc agaaugcagu acagaaccag      360

acggcuguga ugauagaaau agggacaaac cuguugaacc aaacagcgga gcaaacgcgg      420

aaguuaacug auguggaagc ccaaguauua aaucagacca cgagacuuga acuucagcuc      480

uuggaacacu cccucucgac aaacaaauug ggaaaacaga uuuuggacca gaccagugaa      540

auaaacaaau uucaagauaa gaacaguuuc cuagaaaaga aggugcuagc uauggaagac      600

aagcacauca uccaacuaca gucaauaaaa gaagagaaag aucagcuaca gguguuagua      660

uccaagcaaa auuccaucau ugaagaacua gaaaaaaaaa uagugacugc cacugugaau      720

aauucaguuc uucagaagca gcaacaugau cucauggaga caguuaauaa cuuacugacu      780

augaugucca caucaaacuc agcuaaggac cccacuguug cuaaagaaga acaaaucagc      840

uucagagacu gugcugaagu auucaaauca ggacacacca cgaauggcau cuacacguua      900

acauucccua auucuacaga agagaucaag gccuacugug acauggaagc uggaggaggc      960

ggguggacaa uuauucagcg acgugaggau ggcagcguug auuuucagag gacuuggaaa     1020

gaauauaaag ugggauuugg uaacccuuca ggagaauauu ggcugggaaa ugaguuuguu     1080

ucgcaacuga cuaaucagca acgcuaugug cuuaaaauac accuuaaaga cugggaaggg     1140

aaugaggcuu acucauugua ugaacauuuc uaucucucaa gugaagaacu caauuauagg     1200

auucaccuua aaggacuuac agggacagcc ggcaaaauaa gcagcaucag ccaaccagga     1260

aaugauuuua gcacaaagga uggagacaac gacaaaugua uuugcaaaug uucacaaaug     1320

cuaacaggag gcuggugguu ugaugcaugu gguccuucca acuugaacgg aauguacuau     1380

ccacagaggc agaacacaaa uaaguucaac ggcauuaaau gguacuacug gaaaggcuca     1440

ggcuauucgc ucaaggccac aaccaugaug auccgaccag cagauuucua a              1491


<210>  7387
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7387
auguggcaga ucguguucuu cacccugagc ugcgaccucg uccuggccgc cgcguacaac       60

aacuuccgca aguccaugga cagcaucggc aagaagcagu accaggugca gcacgggucc      120

ugcagcuaca ccuuccugcu ccccgagaug gacaacugcc gguccagcuc cagcccguac      180

guguccaacg ccguccagcg cgacgcgccc cuggaguacg acgacagcgu gcagcggcuc      240

caggugcugg agaacaucau ggagaacaac acgcaguggc ugaugaagcu ggagaacuac      300

auccaggaca acaugaagaa ggagaugguc gagauccagc agaacgccgu gcagaaccag      360

accgccguga ugaucgagau cggcaccaac cuccugaacc agaccgccga gcagacgcgc      420

aagcugaccg acgucgaggc ccaggugcuc aaccagacca cccggcugga gcugcagcuc      480

cuggagcacu cccugagcac gaacaagcuc gggaagcaga uccuggacca gaccuccgag      540

aucaacaagu uccaggacaa gaacagcuuc cuggagaaga aggugcucgc cauggaggac      600

aagcacauca uccagcugca guccaucaag gaggagaagg accagcugca gguccucgug      660

agcaagcaga acuccaucau cgaggagcug gagaagaaga ucgugaccgc caccgucaac      720

aacagcgugc ugcagaagca gcagcacgac cucauggaga cggugaacaa ccugcugacc      780

augaugucca ccagcaacag cgcgaaggac cccaccgucg ccaaggagga gcagaucucc      840

uuccgcgacu gcgccgaggu guucaagagc ggccacacga ccaacgggau cuacacccuc      900

accuucccca acuccacgga ggagaucaag gccuacugcg acauggaggc cggcggcggg      960

ggcuggacca ucauccagcg gcgcgaggac gggagcgugg acuuccagcg gaccuggaag     1020

gaguacaagg ucggcuucgg gaacccgucc ggcgaguacu ggcugggcaa cgaguucgug     1080

agccagcuga ccaaccagca gcgcuacgug cucaagaucc accugaagga cugggagggg     1140

aacgaggcgu acucccugua cgagcacuuc uaccucagcu ccgaggagcu gaacuaccgg     1200

auccaccuga agggccucac ggggaccgcc ggcaagauca gcuccaucag ccagcccggc     1260

aacgacuucu ccaccaagga cggggacaac gacaagugca ucugcaagug cagccagaug     1320

cugaccggcg gguggugguu cgacgccugc ggccccucca accugaacgg gauguacuac     1380

ccccagcgcc agaacacgaa caaguucaac ggcaucaagu gguacuacug gaagggcagc     1440

ggguacuccc ucaaggccac caccaugaug auccggccgg ccgacuucug a              1491


<210>  7388
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7388
auguggcaga ucgucuucuu cacccucucc ugcgaccucg uccucgccgc cgccuacaac       60

aacuuccgca aguccaugga cuccaucggc aagaagcagu accaggucca gcacggcucc      120

ugcuccuaca ccuuccuccu ccccgagaug gacaacugcc gcuccuccuc cucccccuac      180

gucuccaacg ccguccagcg cgacgccccc cucgaguacg acgacuccgu ccagcgccuc      240

cagguccucg agaacaucau ggagaacaac acccaguggc ucaugaagcu cgagaacuac      300

auccaggaca acaugaagaa ggagaugguc gagauccagc agaacgccgu ccagaaccag      360

accgccguca ugaucgagau cggcaccaac cuccucaacc agaccgccga gcagacccgc      420

aagcucaccg acgucgaggc ccagguccuc aaccagacca cccgccucga gcuccagcuc      480

cucgagcacu cccucuccac caacaagcuc ggcaagcaga uccucgacca gaccuccgag      540

aucaacaagu uccaggacaa gaacuccuuc cucgagaaga agguccucgc cauggaggac      600

aagcacauca uccagcucca guccaucaag gaggagaagg accagcucca gguccucguc      660

uccaagcaga acuccaucau cgaggagcuc gagaagaaga ucgucaccgc caccgucaac      720

aacuccgucc uccagaagca gcagcacgac cucauggaga ccgucaacaa ccuccucacc      780

augaugucca ccuccaacuc cgccaaggac cccaccgucg ccaaggagga gcagaucucc      840

uuccgcgacu gcgccgaggu cuucaagucc ggccacacca ccaacggcau cuacacccuc      900

accuucccca acuccaccga ggagaucaag gccuacugcg acauggaggc cggcggcggc      960

ggcuggacca ucauccagcg ccgcgaggac ggcuccgucg acuuccagcg caccuggaag     1020

gaguacaagg ucggcuucgg caaccccucc ggcgaguacu ggcucggcaa cgaguucguc     1080

ucccagcuca ccaaccagca gcgcuacguc cucaagaucc accucaagga cugggagggc     1140

aacgaggccu acucccucua cgagcacuuc uaccucuccu ccgaggagcu caacuaccgc     1200

auccaccuca agggccucac cggcaccgcc ggcaagaucu ccuccaucuc ccagcccggc     1260

aacgacuucu ccaccaagga cggcgacaac gacaagugca ucugcaagug cucccagaug     1320

cucaccggcg gcuggugguu cgacgccugc ggccccucca accucaacgg cauguacuac     1380

ccccagcgcc agaacaccaa caaguucaac ggcaucaagu gguacuacug gaagggcucc     1440

ggcuacuccc ucaaggccac caccaugaug auccgccccg ccgacuucug a              1491


<210>  7389
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7389
auguggcaga ucguguucuu uacccugagc ugcgaccucg uccuugccgc ugcauacaac       60

aauuucagaa aguccaugga uucuauuggc aaaaagcaau aucagguuca gcacggguca      120

uguaguuaca cauuucuguu gcccgagaug gacaacugca ggagcuccuc uucgccuuau      180

gugucaaaug ccguacagcg ggaugcgcca uuagaauacg acgauagcgu gcaacgccug      240

cagguccuag agaacauaau ggaaaauaac acucaguggc ucaugaaacu ggagaauuau      300

auccaggaca acaugaagaa agaaauggug gagauucaac agaaugcugu ucagaaccag      360

acggccguga ugaucgagau uggaaccaau cuucugaacc aaacagcaga acagacucga      420

aaguugaccg augucgaggc ccaggugcuc aaucaaacaa cccgucugga acugcagcuc      480

uuagagcaua gucuguccac uaacaaacuu gguaagcaga ucuuggacca gacaucugag      540

auaaauaagu uccaagauaa aaacagcuuu cuggaaaaga aaguacuagc uauggaggac      600

aagcacauca uucagcucca guccaucaag gaagagaaag aucagcugca aguucuugug      660

ucaaagcaga acaguauuau cgaagaacug gagaaaaaga uagucaccgc aacggugaau      720

aacagcgugu ugcagaaaca gcaacaugac cucauggaaa cugucaauaa ccuguuaacc      780

augaugucua cauccaauuc agccaaggau ccgacuguug cuaaagagga acagauuagc      840

uucagagacu gugccgaggu guuuaagagu ggccacacca caaacgggau cuacacccug      900

acguucccca auucuacuga agagauuaag gcguauugcg acauggaggc aggaggcggu      960

ggguggacaa ucauccagag gcgggaagau ggauccguag acuuucagcg caccuggaaa     1020

gaguacaagg ugggcuucgg caacccuagc ggggaauacu ggcucggaaa ugaguuuguc     1080

ucgcaacuua cuaaccagca gagauaugug cugaaaauuc auuugaagga uugggaaggu     1140

aaugaggccu acucucuaua ugagcacuuc uaccuguccu cagaggagcu caacuauagg     1200

auacaccuga aaggccuuac agggaccgcu ggaaagauca guagcauuuc ccaaccaggc     1260

aaugacuuuu cuacgaagga uggugacaac gauaaaugua ucugcaagug uagccagaug     1320

cugaccgggg gauggugguu cgacgccugc ggccccucaa auuugaacgg cauguacuau     1380

ccucagcggc agaacacaaa uaaauucaac gggauaaagu gguacuacug gaaaggaagu     1440

gguuauuccc ucaaggcaac uaccaugaug auucgcccag cugauuuuug a              1491


<210>  7390
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7390
auguggcaga ucguguucuu cacccugagc ugcgaccugg ugcuggccgc cgccuacaac       60

aacuucagaa agagcaugga cagcaucggc aagaagcagu accaggugca gcacggcagc      120

ugcagcuaca ccuuccugcu gcccgagaug gacaacugca gaagcagcag cagccccuac      180

gugagcaacg ccgugcagag agacgccccc cuggaguacg acgacagcgu gcagagacug      240

caggugcugg agaacaucau ggagaacaac acccaguggc ugaugaagcu ggagaacuac      300

auccaggaca acaugaagaa ggagauggug gagauccagc agaacgccgu gcagaaccag      360

accgccguga ugaucgagau cggcaccaac cugcugaacc agaccgccga gcagaccaga      420

aagcugaccg acguggaggc ccaggugcug aaccagacca ccagacugga gcugcagcug      480

cuggagcaca gccugagcac caacaagcug ggcaagcaga uccuggacca gaccagcgag      540

aucaacaagu uccaggacaa gaacagcuuc cuggagaaga aggugcuggc cauggaggac      600

aagcacauca uccagcugca gagcaucaag gaggagaagg accagcugca ggugcuggug      660

agcaagcaga acagcaucau cgaggagcug gagaagaaga ucgugaccgc caccgugaac      720

aacagcgugc ugcagaagca gcagcacgac cugauggaga ccgugaacaa ccugcugacc      780

augaugagca ccagcaacag cgccaaggac cccaccgugg ccaaggagga gcagaucagc      840

uucagagacu gcgccgaggu guucaagagc ggccacacca ccaacggcau cuacacccug      900

accuucccca acagcaccga ggagaucaag gccuacugcg acauggaggc cggcggcggc      960

ggcuggacca ucauccagag aagagaggac ggcagcgugg acuuccagag aaccuggaag     1020

gaguacaagg ugggcuucgg caaccccagc ggcgaguacu ggcugggcaa cgaguucgug     1080

agccagcuga ccaaccagca gagauacgug cugaagaucc accugaagga cugggagggc     1140

aacgaggccu acagccugua cgagcacuuc uaccugagca gcgaggagcu gaacuacaga     1200

auccaccuga agggccugac cggcaccgcc ggcaagauca gcagcaucag ccagcccggc     1260

aacgacuuca gcaccaagga cggcgacaac gacaagugca ucugcaagug cagccagaug     1320

cugaccggcg gcuggugguu cgacgccugc ggccccagca accugaacgg cauguacuac     1380

ccccagagac agaacaccaa caaguucaac ggcaucaagu gguacuacug gaagggcagc     1440

ggcuacagcc ugaaggccac caccaugaug aucagacccg ccgacuucug a              1491


<210>  7391
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7391
auguggcaga ucguguucuu uacccugagc ugcgaccucg uccuggccgc ugccuacaac       60

aauuucagaa aguccaugga uucuauuggc aaaaagcaau aucagguuca gcacgggagc      120

uguuccuaca cauuucuucu gcccgagaug gacaacugcc ggucuagcuc cucuccuuau      180

gugagcaaug cggugcagcg cgaugcuccg cucgaauacg acgauuccgu ccaaagacuu      240

caggugcugg agaacaucau ggaaaauaac acgcaguggc ugaugaaacu cgagaauuau      300

auucaggaca acaugaagaa agaaaugguu gagauccaac agaaugccgu gcagaaccag      360

accgccguca ugauugagau cggaacaaau cugcugaacc aaaccgcuga acagacacgg      420

aagcucaccg auguggaggc ccagguucug aaucaaacaa cccgccuuga acugcagcuc      480

cuggagcaua gccuuucuac gaacaagcug ggcaaacaga uccucgacca gaccuccgag      540

auuaauaagu uccaagauaa aaacagcuuu cuggaaaaga aagugcuggc uauggaggac      600

aagcacauca uucagcucca gucuaucaag gaagagaaag aucagcugca aguccuugug      660

uccaagcaga acagcauuau cgaagaacug gagaaaaaga uugugacagc caccgucaau      720

aacucuguuc uccagaaaca gcaacaugac cugauggaaa cagugaauaa ccuucugacc      780

augaugucca cgagcaauuc cgcgaaggau cccacagugg ccaaagagga acagaucucu      840

uucagagacu gugcugaggu cuuuaagagc gggcacacca caaacggaau cuacacccuc      900

accuucccua auuccacaga agagauuaag gccuauugcg acauggaggc uggcggggga      960

ggcuggacga ucauucagcg gcgcgaagau ggcagcgugg acuuucagag aaccuggaaa     1020

gaguacaagg uuggguucgg aaaccccucu ggcgaauacu ggcuggggaa ugaguuugug     1080

ucccaacuga caaaccagca gcgguauguc cucaaaaucc aucugaagga uugggaagga     1140

aaugaggccu acagccuuua ugagcacuuc uaccugucua gcgaggagcu caacuaucgc     1200

auucaccuga aaggccuuac cgggacagcg ggaaagaucu ccucuaucag ccaaccuggc     1260

aaugacuuuu ccaccaagga uggcgacaac gauaaaugua uuugcaagug uagccagaug     1320

cugacagggg gauggugguu cgacgccugc ggccccucua aucucaacgg gauguacuau     1380

ccucagagac agaacacgaa uaaauucaac ggaaucaagu gguacuacug gaaaggcucc     1440

ggguauagcc ugaaggcuac caccaugaug auucggccgg ccgauuuuug a              1491


<210>  7392
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Angiopoietin-2__Homo_sapiens__BAG35440

<400>  7392
auguggcaaa uaguauucuu uaccuuaucu ugcgauuuag uauuagccgc cgcauauaac       60

aacuuuagaa aaagcaugga cucaaucgga aaaaaacaau aucaagugca acacggauca      120

ugcagcuaua cauuucuacu cccagaaaug gacaacugca gaucaagcag cucaccauau      180

gucucaaacg ccguccaaag agacgcacca cuagaauaug acgacucagu acaaagauua      240

caaguauuag agaauauaau ggaaaacaau acacaauggc uaaugaaacu agaaaauuac      300

auacaagaca auaugaaaaa agaaauggua gaaauacaac aaaacgcagu ccaaaaccaa      360

acagcaguaa ugaucgaaau aggaaccaac uuacuuaacc aaacagcaga acaaacaaga      420

aaacuaacag acguagaagc acaaguccua aaucaaacua caagacuuga auuacaacuu      480

cuagaacauu cauuaucaac aaacaaacuc ggaaaacaaa uacucgacca aacaucagaa      540

auaaauaaau uucaagacaa aaauucauuc cucgaaaaaa aaguauuagc cauggaagac      600

aaacacauaa uacaacuuca aagcauaaag gaagaaaaag accaacuaca aguccuagua      660

ucaaaacaaa auucaauaau agaagaauua gaaaaaaaaa uaguaacagc aacaguaaac      720

aacucaguau uacagaaaca acaacacgac cuaauggaaa cagucaacaa cuuauuaaca      780

augaugucca caucaaacuc agcaaaagau cccacaguag caaaagaaga acaaaucuca      840

uuuagagacu gugcagaagu uuucaaaucc ggacacacaa caaacggcau auauaccuua      900

acuuucccaa auucaacuga agaaauaaaa gcauacugug auauggaagc aggaggaggc      960

ggauggacaa uaauacaacg aagagaagac gguucuguag auuuccaaag aacauggaaa     1020

gaauacaaag uagguuucgg aaauccaagc ggagaauacu ggcuagguaa ugaauucgua     1080

ucacaacuaa caaaccaaca aagauacgua cuaaaaauac acuuaaaaga cugggaaggc     1140

aaugaagcau acucacuaua cgaacacuuu uacuuaucau cagaagagcu aaauuauaga     1200

auucaccuga aaggccucac aggcaccgca ggaaaaauau ccucaaucuc acaaccaggu     1260

aacgacuucu caacaaaaga cggagacaac gacaaaugca uaugcaaaug cucucaaaug     1320

cuaacaggcg guuggugguu cgacgcaugc ggaccgagca aucuaaacgg aauguacuau     1380

ccccaaagac aaaauacaaa caaauucaac ggaaucaaau gguauuacug gaaaggcucc     1440

ggauauagcc uaaaagcaac aacaaugaug auaagaccug cagacuuuua a              1491


<210>  7393
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Angiopoietin-2__Homo_sapiens__O15123

<400>  7393

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     






<210>  7394
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7394
auguggcaga uuguuuucuu uacucugagc ugugaucuug ucuuggccgc agccuauaac       60

aacuuucgga agagcaugga cagcauagga aagaagcaau aucaggucca gcaugggucc      120

ugcagcuaca cuuuccuccu gccagagaug gacaacugcc gcucuuccuc cagccccuac      180

guguccaaug cugugcagag ggacgcgccg cucgaauacg augacucggu gcagaggcug      240

caagugcugg agaacaucau ggaaaacaac acucaguggc uaaugaagcu ugagaauuau      300

auccaggaca acaugaagaa agaaauggua gagauacagc agaaugcagu acagaaccag      360

acggcuguga ugauagaaau agggacaaac cuguugaacc aaacagcuga gcaaacgcgg      420

aaguuaacug auguggaagc ccaaguauua aaucagacca cgagacuuga acuucagcuc      480

uuggaacacu cccucucgac aaacaaauug gaaaaacaga uuuuggacca gaccagugaa      540

auaaacaaau ugcaagauaa gaacaguuuc cuagaaaaga aggugcuagc uauggaagac      600

aagcacauca uccaacuaca gucaauaaaa gaagagaaag aucagcuaca gguguuagua      660

uccaagcaaa auuccaucau ugaagaacua gaaaaaaaaa uagugacugc cacggugaau      720

aauucaguuc uucaaaagca gcaacaugau cucauggaga caguuaauaa cuuacugacu      780

augaugucca caucaaacuc agcuaaggac cccacuguug cuaaagaaga acaaaucagc      840

uucagagacu gugcugaagu auucaaauca ggacacacca caaauggcau cuacacguua      900

acauucccua auucuacaga agagaucaag gccuacugug acauggaagc uggaggaggc      960

ggguggacaa uuauucagcg acgugaggau ggcagcguug auuuucagag gacuuggaaa     1020

gaauauaaag ugggauuugg uaacccuuca ggagaauauu ggcugggaaa ugaguuuguu     1080

ucgcaacuga cuaaucagca acgcuaugug cuuaaaauac accuuaaaga cugggaaggg     1140

aaugaggcuu acucauugua ugaacauuuc uaucucucaa gugaagaacu caauuauagg     1200

auucaccuua aaggacuuac agggacagcc ggcaaaauaa gcagcaucag ccaaccagga     1260

aaugauuuua gcacaaagga uggagacaac gacaaaugua uuugcaaaug uucacaaaug     1320

cuaacaggag gcuggugguu ugaugcaugu gguccuucca acuugaacgg aauguacuau     1380

ccacagaggc agaacacaaa uaaguucaac ggcauuaaau gguacuacug gaaaggcuca     1440

ggcuauucgc ucaaggccac aaccaugaug auccgaccag cagauuucua a              1491


<210>  7395
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7395
auguggcaga ucguguucuu cacccugagc ugcgaccucg uccuggccgc cgcguacaac       60

aacuuccgca aguccaugga cagcaucggc aagaagcagu accaggugca gcacgggucc      120

ugcagcuaca ccuuccugcu ccccgagaug gacaacugcc gguccagcuc cagcccguac      180

guguccaacg ccguccagcg cgacgcgccc cuggaguacg acgacagcgu gcagcggcuc      240

caggugcugg agaacaucau ggagaacaac acgcaguggc ugaugaagcu ggagaacuac      300

auccaggaca acaugaagaa ggagaugguc gagauccagc agaacgccgu gcagaaccag      360

accgccguga ugaucgagau cggcaccaac cuccugaacc agaccgccga gcagacgcgc      420

aagcugaccg acgucgaggc ccaggugcuc aaccagacca cccggcugga gcugcagcuc      480

cuggagcacu cccugagcac gaacaagcuc gagaagcaga uccuggacca gaccuccgag      540

aucaacaagc ugcaggacaa gaacagcuuc cucgagaaga aggugcuggc cauggaggac      600

aagcacauca uccagcugca guccaucaag gaggagaagg accagcucca gguccuggug      660

agcaagcaga acuccaucau cgaggagcug gagaagaaga ucgugaccgc caccgucaac      720

aacagcgugc uccagaagca gcagcacgac cugauggaga cggugaacaa ccugcucacc      780

augaugucca ccagcaacag cgcgaaggac cccaccgucg ccaaggagga gcagaucucc      840

uuccgcgacu gcgccgaggu guucaagagc gggcacacga ccaacggcau cuacacccug      900

accuucccca acuccacgga ggagaucaag gccuacugcg acauggaggc cgggggcggc      960

ggguggacca ucauccagcg gcgcgaggac ggcagcgugg acuuccagcg gaccuggaag     1020

gaguacaagg ucggguucgg caacccgucc ggggaguacu ggcugggcaa cgaguucgug     1080

agccagcuca ccaaccagca gcgcuacgug cugaagaucc accugaagga cugggagggc     1140

aacgaggcgu acucccucua cgagcacuuc uaccugagcu ccgaggagcu gaacuaccgg     1200

auccaccuca aggggcugac gggcaccgcc gggaagauca gcuccaucag ccagcccggc     1260

aacgacuucu ccaccaagga cggcgacaac gacaagugca ucugcaagug cagccagaug     1320

cugaccgggg gcuggugguu cgacgccugc gggcccucca accucaacgg cauguacuac     1380

ccccagcgcc agaacacgaa caaguucaac gggaucaagu gguacuacug gaagggcagc     1440

ggcuacuccc ugaaggccac caccaugaug auccggccgg ccgacuucug a              1491


<210>  7396
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7396
auguggcaga ucgucuucuu cacccucucc ugcgaccucg uccucgccgc cgccuacaac       60

aacuuccgca aguccaugga cuccaucggc aagaagcagu accaggucca gcacggcucc      120

ugcuccuaca ccuuccuccu ccccgagaug gacaacugcc gcuccuccuc cucccccuac      180

gucuccaacg ccguccagcg cgacgccccc cucgaguacg acgacuccgu ccagcgccuc      240

cagguccucg agaacaucau ggagaacaac acccaguggc ucaugaagcu cgagaacuac      300

auccaggaca acaugaagaa ggagaugguc gagauccagc agaacgccgu ccagaaccag      360

accgccguca ugaucgagau cggcaccaac cuccucaacc agaccgccga gcagacccgc      420

aagcucaccg acgucgaggc ccagguccuc aaccagacca cccgccucga gcuccagcuc      480

cucgagcacu cccucuccac caacaagcuc gagaagcaga uccucgacca gaccuccgag      540

aucaacaagc uccaggacaa gaacuccuuc cucgagaaga agguccucgc cauggaggac      600

aagcacauca uccagcucca guccaucaag gaggagaagg accagcucca gguccucguc      660

uccaagcaga acuccaucau cgaggagcuc gagaagaaga ucgucaccgc caccgucaac      720

aacuccgucc uccagaagca gcagcacgac cucauggaga ccgucaacaa ccuccucacc      780

augaugucca ccuccaacuc cgccaaggac cccaccgucg ccaaggagga gcagaucucc      840

uuccgcgacu gcgccgaggu cuucaagucc ggccacacca ccaacggcau cuacacccuc      900

accuucccca acuccaccga ggagaucaag gccuacugcg acauggaggc cggcggcggc      960

ggcuggacca ucauccagcg ccgcgaggac ggcuccgucg acuuccagcg caccuggaag     1020

gaguacaagg ucggcuucgg caaccccucc ggcgaguacu ggcucggcaa cgaguucguc     1080

ucccagcuca ccaaccagca gcgcuacguc cucaagaucc accucaagga cugggagggc     1140

aacgaggccu acucccucua cgagcacuuc uaccucuccu ccgaggagcu caacuaccgc     1200

auccaccuca agggccucac cggcaccgcc ggcaagaucu ccuccaucuc ccagcccggc     1260

aacgacuucu ccaccaagga cggcgacaac gacaagugca ucugcaagug cucccagaug     1320

cucaccggcg gcuggugguu cgacgccugc ggccccucca accucaacgg cauguacuac     1380

ccccagcgcc agaacaccaa caaguucaac ggcaucaagu gguacuacug gaagggcucc     1440

ggcuacuccc ucaaggccac caccaugaug auccgccccg ccgacuucug a              1491


<210>  7397
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7397
auguggcaga ucguguucuu uacccugagc ugcgaccucg uccuugccgc ugcauacaac       60

aauuucagaa aguccaugga uucuauuggc aaaaagcaau aucagguuca gcacggguca      120

uguaguuaca cauuucuguu gcccgagaug gacaacugca ggagcuccuc uucgccuuau      180

gugucaaaug ccguacagcg ggaugcgcca uuagaauacg acgauagcgu gcaacgccug      240

cagguccuag agaacauaau ggaaaauaac acucaguggc ucaugaaacu ggagaauuau      300

auccaggaca acaugaagaa agaaauggug gagauucaac agaaugcugu ucagaaccag      360

acggccguga ugaucgagau uggaaccaau cuucugaacc aaacagcaga acagacucga      420

aaguugaccg augucgaggc ccaggugcuc aaucaaacaa cccgucugga acugcagcuc      480

uuagagcaua gucuguccac uaacaaacuu gagaaacaga ucuuggacca gacaucugaa      540

auaaauaagc ugcaagauaa aaacagcuuc cuagagaaga aaguacucgc uauggaagac      600

aagcacauca uucagcugca guccaucaag gaggaaaaag aucagcuuca aguucuggug      660

ucaaagcaga acaguauuau cgaggaguug gaaaagaaga uagucaccgc aacggugaau      720

aacagcgugc uccagaaaca gcaacaugac cugauggaga cugucaauaa cuuacugacc      780

augaugucua cauccaauuc agccaaggau ccgacuguug cuaaagaaga acagauuagc      840

uuuagagacu gugccgaagu guucaagagu ggucacacca caaacggcau cuacacccuc      900

acguuuccca auucuacuga ggagauuaag gcguauugcg acauggaagc agggggaggc      960

gguuggacaa ucauccagag gcgggaggau ggguccguag acuuccagcg caccuggaaa     1020

gaauacaagg ugggauuugg caacccuagc ggcgaguacu ggcuugggaa ugaguucguc     1080

ucgcaacuga cuaaccagca gagauaugug uugaaaauuc aucuaaagga uugggaggga     1140

aaugaggccu acucucugua ugaacacuuu uaccucuccu cagaggaacu gaacuauagg     1200

auacaccuua aaggucugac aggcaccgcu gggaagauca guagcauuuc ccaaccagga     1260

aaugacuucu cuacgaagga uggcgacaac gauaaaugua ucugcaagug uagccagaug     1320

uugaccggug gguggugguu ugacgccugc ggacccucaa aucucaacgg cauguacuau     1380

ccucagcggc agaacacaaa uaaauucaac ggcauaaagu gguacuacug gaaagggagu     1440

ggauauuccc ugaaggcaac uaccaugaug auucgcccag cugauuucug a              1491


<210>  7398
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7398
auguggcaga ucguguucuu cacccugagc ugcgaccugg ugcuggccgc cgccuacaac       60

aacuucagaa agagcaugga cagcaucggc aagaagcagu accaggugca gcacggcagc      120

ugcagcuaca ccuuccugcu gcccgagaug gacaacugca gaagcagcag cagccccuac      180

gugagcaacg ccgugcagag agacgccccc cuggaguacg acgacagcgu gcagagacug      240

caggugcugg agaacaucau ggagaacaac acccaguggc ugaugaagcu ggagaacuac      300

auccaggaca acaugaagaa ggagauggug gagauccagc agaacgccgu gcagaaccag      360

accgccguga ugaucgagau cggcaccaac cugcugaacc agaccgccga gcagaccaga      420

aagcugaccg acguggaggc ccaggugcug aaccagacca ccagacugga gcugcagcug      480

cuggagcaca gccugagcac caacaagcug gagaagcaga uccuggacca gaccagcgag      540

aucaacaagc ugcaggacaa gaacagcuuc cuggagaaga aggugcuggc cauggaggac      600

aagcacauca uccagcugca gagcaucaag gaggagaagg accagcugca ggugcuggug      660

agcaagcaga acagcaucau cgaggagcug gagaagaaga ucgugaccgc caccgugaac      720

aacagcgugc ugcagaagca gcagcacgac cugauggaga ccgugaacaa ccugcugacc      780

augaugagca ccagcaacag cgccaaggac cccaccgugg ccaaggagga gcagaucagc      840

uucagagacu gcgccgaggu guucaagagc ggccacacca ccaacggcau cuacacccug      900

accuucccca acagcaccga ggagaucaag gccuacugcg acauggaggc cggcggcggc      960

ggcuggacca ucauccagag aagagaggac ggcagcgugg acuuccagag aaccuggaag     1020

gaguacaagg ugggcuucgg caaccccagc ggcgaguacu ggcugggcaa cgaguucgug     1080

agccagcuga ccaaccagca gagauacgug cugaagaucc accugaagga cugggagggc     1140

aacgaggccu acagccugua cgagcacuuc uaccugagca gcgaggagcu gaacuacaga     1200

auccaccuga agggccugac cggcaccgcc ggcaagauca gcagcaucag ccagcccggc     1260

aacgacuuca gcaccaagga cggcgacaac gacaagugca ucugcaagug cagccagaug     1320

cugaccggcg gcuggugguu cgacgccugc ggccccagca accugaacgg cauguacuac     1380

ccccagagac agaacaccaa caaguucaac ggcaucaagu gguacuacug gaagggcagc     1440

ggcuacagcc ugaaggccac caccaugaug aucagacccg ccgacuucug a              1491


<210>  7399
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7399
auguggcaga ucguguucuu uacccugagc ugcgaccucg uccuggccgc ugccuacaac       60

aauuucagaa aguccaugga uucuauuggc aaaaagcaau aucagguuca gcacgggagc      120

uguuccuaca cauuucuucu gcccgagaug gacaacugcc ggucuagcuc cucuccuuau      180

gugagcaaug cggugcagcg cgaugcuccg cucgaauacg acgauuccgu ccaaagacuu      240

caggugcugg agaacaucau ggaaaauaac acgcaguggc ugaugaaacu cgagaauuau      300

auucaggaca acaugaagaa agaaaugguu gagauccaac agaaugccgu gcagaaccag      360

accgccguca ugauugagau cggaacaaau cugcugaacc aaaccgcuga acagacacgg      420

aagcucaccg auguggaggc ccagguucug aaucaaacaa cccgccuuga acugcagcuc      480

cuggagcaua gccuuucuac gaacaagcug gagaaacaga uccucgacca gaccuccgaa      540

auuaauaagc ugcaagauaa aaacagcuuc cuggagaaga aagugcucgc uauggaagac      600

aagcacauca uucagcugca gucuaucaag gaggaaaaag aucagcuuca aguccuggug      660

uccaagcaga acagcauuau cgaggagcuc gagaaaaaga uugugacagc caccgucaau      720

aacucuguuc ugcagaaaca gcaacaugac cuuauggaga cagugaauaa ccugcucacc      780

augaugucca cgagcaauuc cgcgaaggau cccacagugg ccaaagaaga acagaucucu      840

uuuagagacu gugcugaagu cuucaagagc ggccacacca caaacgggau cuacacccug      900

accuuuccua auuccacaga ggagauuaag gccuauugcg acauggaagc uggaggcggg      960

ggauggacga ucauucagcg gcgcgaggau ggcagcgugg acuuccagag aaccuggaaa     1020

gaauacaagg uuggcuuugg gaaccccucu ggagaguacu ggcugggcaa ugaguucgug     1080

ucccaacuca caaaccagca gcgguauguc cugaaaaucc aucuuaagga uugggaaggg     1140

aaugaggccu acagccugua ugaacacuuu uaccucucua gcgaggaacu gaacuaucgc     1200

auucaccuua aaggacugac cggcacagcg gggaagaucu ccucuaucag ccaaccugga     1260

aaugacuucu ccaccaagga uggcgacaac gauaaaugua uuugcaagug uagccagaug     1320

cucacgggcg gguggugguu ugacgccugc ggacccucua aucugaacgg cauguacuau     1380

ccucagagac agaacacaaa uaaauucaac gggaucaagu gguacuacug gaaaggaucc     1440

ggcuauagcc ugaaggcuac caccaugaug auucggccgg ccgauuucug a              1491


<210>  7400
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Angiopoietin-2__Homo_sapiens__AAB63190

<400>  7400
auguggcaaa uagucuuuuu cacucuauca ugugaccuag uacuagcagc agcauauaac       60

aauuuuagaa aaucaaugga caguauagga aaaaaacaau accaaguaca acacgguucc      120

ugcuccuaua cauucuuacu accagaaaug gacaauugca gaagcucaag uucaccauac      180

guaucuaacg caguacaaag agacgcacca uuagaauacg acgacucagu acaacgacua      240

caaguacuag aaaacauaau ggaaaacaau acacaauggc uaaugaaauu agaaaauuau      300

auccaagaca acaugaaaaa agaaauggua gaaauacaac aaaacgcagu ccaaaaccaa      360

acagcaguaa ugauagaaau cggaacaaac cuacuaaacc aaacagcaga acaaacaaga      420

aaacuuacag acguagaagc ucaaguauua aaccaaacaa caagacuaga acuacaacua      480

cuagaacacu cacuaaguac aaauaaacuc gaaaaacaaa uauuagauca aacaagcgaa      540

auaaauaaau uacaggauaa aaacucauuc cucgagaaaa aaguauuagc aauggaagau      600

aaacacauaa uacaacuaca aucaauaaaa gaagaaaaag accaacucca aguauuagua      660

aguaaacaaa auagcauaau agaagaauua gaaaaaaaaa uaguaacugc aacaguaaac      720

aacucaguac uacaaaaaca acaacacgac cuaauggaaa caguaaacaa cuuacuaaca      780

augaugagca caucaaacuc agcaaaagac ccaaccguag caaaagaaga acaaaucuca      840

uuccgugauu gcgccgaagu auucaaauca ggccacacaa caaacggcau cuauacauua      900

acauucccaa acucaacuga agaaauaaaa gcauacugcg auauggaagc cggaggaggc      960

ggauggacca uaauacaaag aagagaagac ggaagcguag auuuucaaag gacauggaaa     1020

gaauacaaag uaggauucgg uaacccaagu ggagaauacu gguuaggaaa cgaauucgua     1080

agccaacuaa caaaccaaca aagguacgua cucaaaauac accuuaaaga uugggaagga     1140

aacgaagcau auucccuaua cgaacacuuc uacuuaagcu ccgaagaacu aaauuaucga     1200

auacauuuaa aagggcuaac aggcacagcc ggaaaaauau caaguauaag ucaaccagga     1260

aacgacuucu caacaaaaga cggagacaac gacaaaugca uaugcaaaug cucacaaaug     1320

cuaaccggag gauggugguu cgacgcaugc ggaccaucaa accucaacgg aauguacuau     1380

ccccagagac aaaacacaaa caaauuuaac ggaauaaaau gguauuacug gaaaggauca     1440

ggauacaguc ucaaagcuac aacaaugaug auuagaccag cagauuucua a              1491


<210>  7401
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__A0A0F7G8J1

<400>  7401

Met Asp His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Leu Gly Asp Ser Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Phe 
            20                  25                  30          


Leu Phe Ser Leu Ser Arg Lys Gln Val Ala Ala Arg Ser Val Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Ala Glu Thr Asn Phe Ile Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Asp Gln Gln Cys Val Val Met Ala Glu Asn Ser 
65                  70                  75                  80  


Lys Thr Ser Pro Ile Ala Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Arg Ile Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Thr Ser Lys Thr Lys Ser Gly Val Ile Cys Gln Lys Trp Ser 
        115                 120                 125             


Val Ser Ser Pro His Ile Pro Lys Tyr Ser Pro Glu Lys Phe Pro Leu 
    130                 135                 140                 


Ala Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Glu Lys 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Thr Arg Phe Asp Tyr Cys 
                165                 170                 175     


Asp Ile Pro Glu Cys Glu Asp Glu Cys Met His Cys Ser Gly Glu His 
            180                 185                 190         


Tyr Glu Gly Lys Ile Ser Lys Thr Met Ser Gly Ile Glu Cys Gln Ser 
        195                 200                 205             


Trp Gly Ser Gln Ser Pro His Ala His Gly Tyr Leu Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Met Asn Tyr Cys Arg Asn Pro Asp Gly Glu 
225                 230                 235                 240 


Pro Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Phe 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Thr Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Arg Gly Glu Asn Tyr Arg Gly Thr Val Ser 
        275                 280                 285             


Val Thr Ala Ser Gly His Thr Cys Gln Arg Trp Ser Ala Gln Ser Pro 
    290                 295                 300                 


His Lys His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Glu 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Glu Thr Ala Pro Trp Cys Tyr 
                325                 330                 335     


Thr Thr Asp Ser Glu Val Arg Trp Asp Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Gly Ser Ser Thr Thr Ser Thr Glu His Leu Asp Ala Pro Val Pro Pro 
        355                 360                 365             


Glu Gln Thr Pro Val Ala Gln Asp Cys Tyr Arg Gly Asn Gly Glu Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Ile Thr Gly Arg Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Val Ser Met Thr Pro His Arg His Glu Lys Thr Pro Gly Asn Phe 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Ser Pro Trp Cys Tyr Thr Thr Asp Pro Arg Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Glu Thr Glu Gln Gln Val Thr Asn Phe 
    450                 455                 460                 


Pro Ala Ile Ala Gln Val Pro Ser Val Glu Asp Leu Ser Glu Asp Cys 
465                 470                 475                 480 


Met Phe Gly Asn Gly Lys Arg Tyr Arg Gly Lys Arg Ala Thr Thr Val 
                485                 490                 495     


Ala Gly Val Pro Cys Gln Glu Trp Ala Ala Gln Glu Pro His Arg His 
            500                 505                 510         


Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn 
        515                 520                 525             


Tyr Cys Arg Asn Pro Asp Gly Asp Asp Asn Gly Pro Trp Cys Tyr Thr 
    530                 535                 540                 


Thr Asn Pro Gln Lys Leu Phe Asp Tyr Cys Asp Val Pro Gln Cys Val 
545                 550                 555                 560 


Thr Ser Ser Phe Asp Cys Gly Lys Pro Lys Val Glu Pro Lys Lys Cys 
                565                 570                 575     


Pro Ala Arg Val Val Gly Gly Cys Val Ser Ile Pro His Ser Trp Pro 
            580                 585                 590         


Trp Gln Ile Ser Leu Arg Tyr Arg Tyr Arg Gly His Phe Cys Gly Gly 
        595                 600                 605             


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Lys His Cys Leu Glu 
    610                 615                 620                 


Lys Ser Ser Ser Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Glu 
625                 630                 635                 640 


Glu Tyr His Leu Gly Glu Gly Val Gln Glu Ile Asp Val Ser Lys Leu 
                645                 650                 655     


Phe Lys Glu Pro Ser Gly Ala Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            660                 665                 670         


Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Thr Pro 
        675                 680                 685             


Asn Tyr Val Val Ala Asp Arg Thr Ala Cys Tyr Ile Thr Gly Trp Gly 
    690                 695                 700                 


Glu Thr Lys Gly Thr Tyr Gly Ala Gly Leu Leu Lys Glu Ala Arg Leu 
705                 710                 715                 720 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Tyr Leu Gly Gly 
                725                 730                 735     


Lys Val Ser Pro Asn Glu Leu Cys Ala Gly His Leu Ala Gly Gly Ile 
            740                 745                 750         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        755                 760                 765             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    770                 775                 780                 


Leu Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
785                 790                 795                 800 


Trp Ile Glu Glu Ile Met Arg Arg Asn 
                805                 


<210>  7402
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__AKG50977

<400>  7402
auggaccaua aagagguagu ucuucuccuu cuuuuauuuc ugaaaucagg ucucggggac       60

ucucuggaug acuacgucaa uacucaggga gcuuuccugu ucaguuuguc ucggaagcag      120

guggcagcca ggagcgugga agaaugugca gccaagugug aggcggaaac aaacuucauu      180

ugcagggcuu uccaguauca caguaaagau cagcagugug uggugauggc ugagaacagc      240

aagaccuccc ccaucgcuag gaugagagac gugguucuau ucgagaagag aaucuaucuc      300

uccgagugca agacuggaaa ugggaagaac uacagaggga ccacguccaa aacgaaaagu      360

ggugucaucu gucaaaaaug gagugucagc ucuccgcaca uacccaagua uucaccugaa      420

aaguuuccuu uagcgggacu ggaggagaac uacugcagga acccagacaa cgaugaaaag      480

ggacccuggu guuacaccac ugacccagag acccgauucg acuacugcga caucccugag      540

ugugaagaug aaugcaugca cugcagugga gaacauuaug agggcaaaau uuccaagacc      600

augucgggga uugaaugcca gucuuggggc ucucagagcc cacaugcuca cggauaccuu      660

ccuuccaaau uuccaaacaa gaaucugaag augaauuacu gccguaaccc ggauggggag      720

ccccgcccau ggugcuucac cacggauccc aacaaacgcu gggaauucug ugacaucccg      780

agaugcacca cacccccacc aacuuccggg ccaacguauc agugucugaa gggaagaggu      840

gaaaacuacc gagggacagu gucugucacu gcaucugggc acaccuguca acgcuggagu      900

gcgcagagcc cccacaagca caacaggacc cccgaaaacu uucccugcaa aaaucuggag      960

gagaacuacu gccguaaccc ugauggagaa acggcuccgu ggugcuacac aaccgacagc     1020

gaggugaggu gggauuacug caagauaccg uccugugggu ccuccacgac auccacggag     1080

caucuggaug cccccgugcc acccgagcaa accccugucg cccaggacug cuacagaggc     1140

aauggggaga guuaccgagg cacgucuucc acaaccauca cgggaagaaa augucagucc     1200

uggguaucca ugacgccaca ucggcaugag aagaccccag gaaacuuccc aaaugcuggc     1260

uugacaauga acuacugcag gaacccagac gcugauaaaa gcccuuggug cuacaccacu     1320

gauccaagag ugagauggga guacugcaac cugaagaaau gcucagagac agaacagcag     1380

gucacaaacu uuccagcuau ugcgcagguu cccaguguag aggaucuuuc ggaagacugc     1440

auguucggga augggaaaag guaccggggc aagagggcca ccacgguggc cggcgucccc     1500

ugccaggagu gggcugccca ggagccccac agacacagca ucuucacucc agagacaaau     1560

ccacgggcag gucuggagaa aaauuacugc cguaauccug acggcgacga caacgguccc     1620

uggugcuaca cgacaaaccc acaaaagcuc uuugacuacu gcgacguccc ucagugugua     1680

accucuucau uugauugcgg gaagcccaag guggagccaa agaagugucc ugcgagggug     1740

guaggugggu guguguccau cccacacucc uggcccuggc aaauuagccu ucgauacagg     1800

uacagagggc acuucugcgg aggcacuuua auauccccgg agugggugcu gacugcuaag     1860

cacugccugg aaaaguccuc aaguccuuca ucauacaagg ucauuuuggg ugcacacgaa     1920

gaguaccacc uuggagaagg aguucaggag auagacgugu ccaagcuguu caaggagccc     1980

ucuggggcgg acauagccuu gcucaagcug agcagcccug ccgucaucac ugacaaggua     2040

aucccggcuu gucugccaac cccgaacuau guggucgccg accggacagc guguuacauc     2100

acuggcuggg gagaaaccaa aggcacguac ggcgcuggcu uacuuaagga agcccggcug     2160

cccgugauug agaacaaagu guguaaucgc uacgaguauc ugggcgggaa ggucagcccc     2220

aacgagcugu gugcggggca ucuggcugga ggcaucgaca gcugccaggg ugacagcgga     2280

gggccucugg ugugcuuuga gaaggacaaa uacauuuuac aaggagucac uucuuggggu     2340

cuuggcugug cgcuccccaa uaagccuggu guguaugucc guguuucaag guuuguuacu     2400

uggauugagg aaauaaugag aagaaauuaa                                      2430


<210>  7403
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7403
auggaccaca aggagguggu ccugcuccug cuccuguucc ucaagagcgg ccugggggac       60

ucccuggacg acuacgugaa cacccagggc gccuuccugu ucagccuguc ccgcaagcag      120

gucgccgcgc ggagcgugga ggagugcgcc gccaagugcg aggccgagac caacuucauc      180

ugccgcgccu uccaguacca cuccaaggac cagcagugcg uggugauggc ggagaacagc      240

aagacguccc ccaucgcccg gaugcgcgac gucguccucu ucgagaagcg gaucuaccug      300

agcgagugca agaccgggaa cggcaagaac uaccgcggga ccaccuccaa gaccaagagc      360

ggcgugaucu gccagaagug guccgugagc uccccgcaca uccccaagua cagccccgag      420

aaguuccccc uggccggccu cgaggagaac uacugccgga acccggacaa cgacgagaag      480

gggcccuggu gcuacaccac cgaccccgag acccgcuucg acuacugcga cauccccgag      540

ugcgaggacg agugcaugca cugcuccggc gagcacuacg aggggaagau cagcaagacg      600

auguccggca ucgagugcca gagcuggggg ucccagagcc cgcacgccca cggcuaccug      660

cccagcaagu uccccaacaa gaaccugaag augaacuacu gccggaaccc cgacggcgag      720

ccgcgccccu ggugcuucac caccgacccc aacaagcggu gggaguucug cgacaucccc      780

cgcugcacca cgccgccgcc caccuccggg cccaccuacc agugccucaa gggccgcggg      840

gagaacuacc ggggcaccgu gagcgugacg gcguccggcc acacgugcca gcgguggagc      900

gcccagagcc cccacaagca caaccgcacc cccgagaacu uccccugcaa gaaccuggag      960

gagaacuacu gccggaaccc cgacggggag accgccccgu ggugcuacac gaccgacucc     1020

gagguccgcu gggacuacug caagaucccc uccugcggca gcuccaccac cagcacggag     1080

caccuggacg cccccgugcc cccggagcag acccccgugg cccaggacug cuaccggggg     1140

aacggcgagu ccuaccgcgg gaccagcucc accacgauca ccggccggaa gugccagagc     1200

ugggucucca ugacgcccca ccgccacgag aagaccccgg gcaacuuccc caacgcgggg     1260

cucaccauga acuacugccg caaccccgac gccgacaaga gccccuggug cuacaccacc     1320

gacccgcggg ugcgcuggga guacugcaac cugaagaagu gcuccgagac cgagcagcag     1380

gucacgaacu uccccgccau cgcccaggug cccagcgugg aggaccuguc cgaggacugc     1440

auguucggca acgggaagcg guaccgcggc aagcgggcca ccaccguggc gggggucccc     1500

ugccaggagu gggccgccca ggagccgcac cgccacagca ucuucacccc cgagaccaac     1560

ccccgggccg gccucgagaa gaacuacugc cgcaaccccg acggcgacga caacgggccg     1620

uggugcuaca cgaccaaccc ccagaagcug uucgacuacu gcgacgugcc ccagugcgug     1680

accagcuccu ucgacugcgg caagcccaag gucgagccga agaagugccc cgcccgggug     1740

gucgggggcu gcgugagcau cccccacucc uggcccuggc agaucagccu gcgcuaccgg     1800

uaccgcgggc acuucugcgg cggcacccuc aucuccccgg agugggugcu gacggcgaag     1860

cacugccugg agaaguccag cagccccucc agcuacaagg ucauccucgg ggcccacgag     1920

gaguaccacc ugggcgaggg ggugcaggag aucgacgugu ccaagcuguu caaggagccc     1980

agcggcgccg acaucgcccu ccugaagcug uccagccccg ccgucaucac cgacaaggug     2040

aucccggcgu gccuccccac ccccaacuac guggucgccg accggaccgc cugcuacauc     2100

acgggcuggg gcgagaccaa ggggaccuac ggggccggcc ugcugaagga ggcgcgccuc     2160

ccggugaucg agaacaaggu gugcaaccgg uacgaguacc ucgggggcaa ggucuccccc     2220

aacgagcugu gcgccggcca ccuggccggg ggcaucgaca gcugccaggg ggacuccggc     2280

gggccccugg ugugcuucga gaaggacaag uacauccugc agggcgugac cagcuggggc     2340

cucgggugcg cccugcccaa caagccgggc gucuacgugc gcgugagccg guucgucacg     2400

uggaucgagg agaucaugcg ccggaacuga                                      2430


<210>  7404
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7404
auggaccaca aggaggucgu ccuccuccuc cuccucuucc ucaaguccgg ccucggcgac       60

ucccucgacg acuacgucaa cacccagggc gccuuccucu ucucccucuc ccgcaagcag      120

gucgccgccc gcuccgucga ggagugcgcc gccaagugcg aggccgagac caacuucauc      180

ugccgcgccu uccaguacca cuccaaggac cagcagugcg ucgucauggc cgagaacucc      240

aagaccuccc ccaucgcccg caugcgcgac gucguccucu ucgagaagcg caucuaccuc      300

uccgagugca agaccggcaa cggcaagaac uaccgcggca ccaccuccaa gaccaagucc      360

ggcgucaucu gccagaagug guccgucucc uccccccaca uccccaagua cucccccgag      420

aaguuccccc ucgccggccu cgaggagaac uacugccgca accccgacaa cgacgagaag      480

ggccccuggu gcuacaccac cgaccccgag acccgcuucg acuacugcga cauccccgag      540

ugcgaggacg agugcaugca cugcuccggc gagcacuacg agggcaagau cuccaagacc      600

auguccggca ucgagugcca guccuggggc ucccaguccc cccacgccca cggcuaccuc      660

cccuccaagu uccccaacaa gaaccucaag augaacuacu gccgcaaccc cgacggcgag      720

ccccgccccu ggugcuucac caccgacccc aacaagcgcu gggaguucug cgacaucccc      780

cgcugcacca cccccccccc caccuccggc cccaccuacc agugccucaa gggccgcggc      840

gagaacuacc gcggcaccgu cuccgucacc gccuccggcc acaccugcca gcgcuggucc      900

gcccaguccc cccacaagca caaccgcacc cccgagaacu uccccugcaa gaaccucgag      960

gagaacuacu gccgcaaccc cgacggcgag accgcccccu ggugcuacac caccgacucc     1020

gagguccgcu gggacuacug caagaucccc uccugcggcu ccuccaccac cuccaccgag     1080

caccucgacg cccccguccc ccccgagcag acccccgucg cccaggacug cuaccgcggc     1140

aacggcgagu ccuaccgcgg caccuccucc accaccauca ccggccgcaa gugccagucc     1200

ugggucucca ugacccccca ccgccacgag aagacccccg gcaacuuccc caacgccggc     1260

cucaccauga acuacugccg caaccccgac gccgacaagu cccccuggug cuacaccacc     1320

gacccccgcg uccgcuggga guacugcaac cucaagaagu gcuccgagac cgagcagcag     1380

gucaccaacu uccccgccau cgcccagguc cccuccgucg aggaccucuc cgaggacugc     1440

auguucggca acggcaagcg cuaccgcggc aagcgcgcca ccaccgucgc cggcgucccc     1500

ugccaggagu gggccgccca ggagccccac cgccacucca ucuucacccc cgagaccaac     1560

ccccgcgccg gccucgagaa gaacuacugc cgcaaccccg acggcgacga caacggcccc     1620

uggugcuaca ccaccaaccc ccagaagcuc uucgacuacu gcgacguccc ccagugcguc     1680

accuccuccu ucgacugcgg caagcccaag gucgagccca agaagugccc cgcccgcguc     1740

gucggcggcu gcgucuccau cccccacucc uggcccuggc agaucucccu ccgcuaccgc     1800

uaccgcggcc acuucugcgg cggcacccuc aucucccccg aguggguccu caccgccaag     1860

cacugccucg agaaguccuc cucccccucc uccuacaagg ucauccucgg cgcccacgag     1920

gaguaccacc ucggcgaggg cguccaggag aucgacgucu ccaagcucuu caaggagccc     1980

uccggcgccg acaucgcccu ccucaagcuc uccucccccg ccgucaucac cgacaagguc     2040

auccccgccu gccuccccac ccccaacuac gucgucgccg accgcaccgc cugcuacauc     2100

accggcuggg gcgagaccaa gggcaccuac ggcgccggcc uccucaagga ggcccgccuc     2160

cccgucaucg agaacaaggu cugcaaccgc uacgaguacc ucggcggcaa ggucuccccc     2220

aacgagcucu gcgccggcca ccucgccggc ggcaucgacu ccugccaggg cgacuccggc     2280

ggcccccucg ucugcuucga gaaggacaag uacauccucc agggcgucac cuccuggggc     2340

cucggcugcg cccuccccaa caagcccggc gucuacgucc gcgucucccg cuucgucacc     2400

uggaucgagg agaucaugcg ccgcaacuga                                      2430


<210>  7405
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7405
auggaccaca aggagguggu ccugcuccuu cuguuguucu uaaaaagcgg ccugggggau       60

ucccuagacg auuacguuaa cacccaggga gccuuucucu ucucucuguc aagaaagcaa      120

guggcugcaa ggaguguaga agagugcgcc gcgaaaugug aagcugagac aaauuuuauc      180

ugccgggccu uccaguauca uagcaaggac cagcagugug uggucauggc agaaaacucc      240

aaaacuucuc ccauugcccg caugcgagau gugguucuuu uugagaagcg uauauaccug      300

ucggagugca agacggguaa uggcaaaaac uauagaggga ccacaucaaa gacuaaaagc      360

ggagugaucu gucaaaagug gagugucucc ucuccucaca uuccaaaaua cagcccggaa      420

aaguuccccu uggcuggccu cgaggaaaau uauugcagga acccugacaa ugaugagaag      480

gguccauggu guuacaccac agaccccgag acccgguuug auuauugcga caucccugaa      540

ugugaggaug aaugcaugca uuguuccggg gagcacuacg aaggaaaaau uucaaagacu      600

augaguggca ucgagugcca gagcuggggc ucucaguccc cacaugcaca cggguaccug      660

cccucaaaau ucccuaacaa gaaucugaaa augaacuauu gccgcaaucc agacggagag      720

ccgagacccu gguguuuuac aaccgauccu aacaagaggu gggaguucug cgacauacca      780

cgguguacga cucccccucc aaccagcggu cccacauacc agugccucaa aggccgcggg      840

gaaaauuauc gaggaacugu gaguguaacc gccucuggcc acacauguca aagauggucc      900

gcucagagcc cgcauaagca caacaggacc ccugaaaauu uucccugcaa gaacuuagag      960

gaaaacuacu gucggaaucc agacggugag acggccccuu ggugcuauac uacagauucg     1020

gagguucguu gggacuacug uaaaaucccc ucuugcgggu ccucaaccac aaguacugaa     1080

caucuggaug cgccagugcc cccugagcag accccagucg cacaggacug uuaucgcgga     1140

aacggcgaaa gcuacagagg cacguccucu accacaauua cugggaggaa gugccaaagc     1200

ugggugucaa ugaccccgca ccggcacgag aaaacacccg gaaauuuccc uaacgccggu     1260

cuuacuauga auuacugccg aaacccagau gcugacaaga gucccuggug uuauaccaca     1320

gauccucgcg ugagauggga auacugcaau uugaaaaagu guuccgagac cgagcagcag     1380

gucacuaacu uuccagccau cgcacaaguu cccagcgugg aagaccuguc ugaggauugc     1440

auguucggca augggaagag guaucgggga aaacgcgcua cgacaguagc cggcgugccg     1500

ugucaggaau gggcggccca ggagccucau agacacucaa uuuucacccc agagacuaac     1560

cccagggcag gucuagaaaa gaauuacugc cguaacccug acggggauga caauggcccc     1620

ugguguuaua ccacaaaccc acagaaacuc uuugacuacu gcgauguccc ucaaugugug     1680

accaguagcu ucgacugcgg aaagcccaaa guugagccaa agaagugucc ggcucgggug     1740

gucggcgggu gcguguccau cccucauucu uggcccuggc agauaucgcu gcgauauaga     1800

uacaggggac acuuuugcgg uggcacucuu auuagcccag aauggguacu gacagccaaa     1860

cauuguuugg agaaguccuc aagucccucu agcuacaaag uuauccucgg ggcucacgaa     1920

gaguaucacc ugggagaggg cgugcaggaa auugaugucu ccaaguuauu caaagagccu     1980

ucaggugccg acaucgcacu gcucaaacuu agcucuccag ccgugaucac ggauaagguc     2040

auucccgcuu gccugccuac cccgaauuac gugguugcgg accgcacugc auguuauaua     2100

acaggguggg gcgaaaccaa gggaacauac ggcgccgggu ugcuaaagga ggcucggcug     2160

ccagugaucg aaaacaaagu augcaacaga uaugaguacc ucggagguaa ggucuccccc     2220

aaugagcugu gugccggcca ucuugcaggg ggaauugaua guugccaggg cgacagcggu     2280

gggccucugg uguguuuuga aaaagauaag uauaucuugc aaggcguuac uucuugggga     2340

cucggcugcg cccugccaaa caaacccggg guguacguca gggugucccg cuucguaacc     2400

uggauagagg aaauuaugcg acggaauuga                                      2430


<210>  7406
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7406
auggaccaca aggagguggu gcugcugcug cugcuguucc ugaagagcgg ccugggcgac       60

agccuggacg acuacgugaa cacccagggc gccuuccugu ucagccugag cagaaagcag      120

guggccgcca gaagcgugga ggagugcgcc gccaagugcg aggccgagac caacuucauc      180

ugcagagccu uccaguacca cagcaaggac cagcagugcg uggugauggc cgagaacagc      240

aagaccagcc ccaucgccag aaugagagac guggugcugu ucgagaagag aaucuaccug      300

agcgagugca agaccggcaa cggcaagaac uacagaggca ccaccagcaa gaccaagagc      360

ggcgugaucu gccagaagug gagcgugagc agcccccaca uccccaagua cagccccgag      420

aaguuccccc uggccggccu ggaggagaac uacugcagaa accccgacaa cgacgagaag      480

ggccccuggu gcuacaccac cgaccccgag accagauucg acuacugcga cauccccgag      540

ugcgaggacg agugcaugca cugcagcggc gagcacuacg agggcaagau cagcaagacc      600

augagcggca ucgagugcca gagcuggggc agccagagcc cccacgccca cggcuaccug      660

cccagcaagu uccccaacaa gaaccugaag augaacuacu gcagaaaccc cgacggcgag      720

cccagacccu ggugcuucac caccgacccc aacaagagau gggaguucug cgacaucccc      780

agaugcacca cccccccccc caccagcggc cccaccuacc agugccugaa gggcagaggc      840

gagaacuaca gaggcaccgu gagcgugacc gccagcggcc acaccugcca gagauggagc      900

gcccagagcc cccacaagca caacagaacc cccgagaacu uccccugcaa gaaccuggag      960

gagaacuacu gcagaaaccc cgacggcgag accgcccccu ggugcuacac caccgacagc     1020

gaggugagau gggacuacug caagaucccc agcugcggca gcagcaccac cagcaccgag     1080

caccuggacg cccccgugcc ccccgagcag acccccgugg cccaggacug cuacagaggc     1140

aacggcgaga gcuacagagg caccagcagc accaccauca ccggcagaaa gugccagagc     1200

ugggugagca ugacccccca cagacacgag aagacccccg gcaacuuccc caacgccggc     1260

cugaccauga acuacugcag aaaccccgac gccgacaaga gccccuggug cuacaccacc     1320

gaccccagag ugagauggga guacugcaac cugaagaagu gcagcgagac cgagcagcag     1380

gugaccaacu uccccgccau cgcccaggug cccagcgugg aggaccugag cgaggacugc     1440

auguucggca acggcaagag auacagaggc aagagagcca ccaccguggc cggcgugccc     1500

ugccaggagu gggccgccca ggagccccac agacacagca ucuucacccc cgagaccaac     1560

cccagagccg gccuggagaa gaacuacugc agaaaccccg acggcgacga caacggcccc     1620

uggugcuaca ccaccaaccc ccagaagcug uucgacuacu gcgacgugcc ccagugcgug     1680

accagcagcu ucgacugcgg caagcccaag guggagccca agaagugccc cgccagagug     1740

gugggcggcu gcgugagcau cccccacagc uggcccuggc agaucagccu gagauacaga     1800

uacagaggcc acuucugcgg cggcacccug aucagccccg agugggugcu gaccgccaag     1860

cacugccugg agaagagcag cagccccagc agcuacaagg ugauccuggg cgcccacgag     1920

gaguaccacc ugggcgaggg cgugcaggag aucgacguga gcaagcuguu caaggagccc     1980

agcggcgccg acaucgcccu gcugaagcug agcagccccg ccgugaucac cgacaaggug     2040

auccccgccu gccugcccac ccccaacuac gugguggccg acagaaccgc cugcuacauc     2100

accggcuggg gcgagaccaa gggcaccuac ggcgccggcc ugcugaagga ggccagacug     2160

cccgugaucg agaacaaggu gugcaacaga uacgaguacc ugggcggcaa ggugagcccc     2220

aacgagcugu gcgccggcca ccuggccggc ggcaucgaca gcugccaggg cgacagcggc     2280

ggcccccugg ugugcuucga gaaggacaag uacauccugc agggcgugac cagcuggggc     2340

cugggcugcg cccugcccaa caagcccggc guguacguga gagugagcag auucgugacc     2400

uggaucgagg agaucaugag aagaaacuga                                      2430


<210>  7407
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7407
auggaccaca aggagguggu ccugcuccug cuucuguucc ucaaaagcgg ccugggggau       60

ucccuugacg auuacguuaa cacccaggga gccuuucugu ucucucucag cagaaagcaa      120

guggcugccc gguccgugga agagugcgcg gcuaaaugug aagccgagac aaauuuuauc      180

ugccgcgccu uccaguauca uucuaaggac cagcagugug ucgugauggc ugaaaacagc      240

aaaacguccc ccauugccag aaugcgggau guugugcugu uugagaagcg caucuaccug      300

ucugagugca agaccggcaa ugggaaaaac uauagaggaa caaccagcaa gacaaaaucc      360

ggcgucauuu gucaaaagug gagcgugucu uccccucaca ucccgaaaua cagccccgaa      420

aaguucccuc ucgcugggcu ggaggaaaau uauugccgga accccgacaa ugaugagaag      480

ggaccuuggu guuacaccac agaccccgag acccgcuuug auuauugcga cauuccugaa      540

ugugaggaug aaugcaugca uuguucuggc gagcacuacg aaggcaaaau cuccaagacg      600

augagcggga ucgagugcca gucuugggga ucccagagcc cgcaugccca cggcuaccuu      660

cccuccaaau ucccuaacaa gaaucugaaa augaacuauu gcagaaaucc cgacggggag      720

ccucggcccu gguguuuuac cacagauccg aacaagcgcu gggaguucug cgacauuccu      780

agauguacca cacccccucc caccucugga cccacguacc agugccucaa aggccgcggg      840

gaaaauuauc ggggaacagu uagcgugacc gcguccggcc acacauguca aagauggagc      900

gcccagucuc cucauaagca caaccggacc ccggaaaauu uucccugcaa gaaccuggag      960

gaaaacuacu gucgcaaucc ugacggcgag accgcucccu ggugcuauac aacggauucc     1020

gaggucagau gggacuacug uaaaaucccu agcugcgggu cuagcaccac auccaccgaa     1080

caucuugaug cccccgugcc gccugagcag acacccgugg cucaggacug uuaucgggga     1140

aacggcgaau cuuacagagg gaccagcucc acgacaauua ccggacgcaa gugccaaagc     1200

ugggucucua ugaccccuca ccggcacgag aaaacacccg gcaauuuccc uaacgccggg     1260

cugaccauga auuacugcag aaaccccgau gcggacaagu ccccguggug uuauacaacg     1320

gauccucgcg uucgguggga auacugcaau cucaaaaagu guagcgagac cgagcaacag     1380

gugacaaacu uucccgccau cgcucaggug cccucugucg aagaccuguc cgaggauugc     1440

auguucggaa auggcaagag auaucgcggc aaacgggcca ccacaguggc ugggguuccu     1500

ugucaggaau gggccgccca ggagccgcau agacacagca uuuucacccc cgagacgaac     1560

ccucgcgcug gacuggaaaa gaauuacugc cggaaccccg acggcgauga caaugggccu     1620

ugguguuaua ccacaaaccc ccagaaacuc uuugacuacu gcgaugugcc ucaauguguc     1680

accuccucuu ucgacugcgg aaagcccaaa guggagccga agaagugucc ugcgagaguu     1740

gugggcgggu gcgucagcau cccccauucc uggccuuggc agauuucucu gcgcuaucgg     1800

uacagaggcc acuuuugcgg aggcacacuu aucagccccg aaugggugcu gaccgccaaa     1860

cauugucucg agaaguccag cucuccgucc agcuacaaag ucauccuggg ggcucacgaa     1920

gaguaucacc uuggagaggg cgugcaggaa auugauguuu cuaagcuguu caaagagccu     1980

uccggggccg acaucgcccu ccugaagcug agcucucccg cugugauuac ggauaagguc     2040

aucccugccu gccuccccac acccaauuac gugguugcgg accggaccgc uuguuauauu     2100

acaggauggg gcgaaaccaa agggaccuac ggcgccggac ugcuuaagga ggcccgccug     2160

ccugugaucg aaaacaaagu cugcaacaga uaugaguacc ucggcgggaa ggugagcccg     2220

aaugagcugu gugcuggaca ucuugccggc gggaucgauu ccugccaggg agacagcggc     2280

gggccccugg uguguuuuga aaaagauaag uauauucucc aaggcguuac aucuugggga     2340

cugggcugcg cucugccuaa caaacccggg gucuacgugc ggguguccag auucgucacg     2400

uggaucgagg aaauuaugcg ccggaauuga                                      2430


<210>  7408
<211>  2430
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Angiostatin__Homo_sapiens__AKG50977

<400>  7408
auggaucaua aagagguagu auuacuauug uuacuauuuu uaaaauccgg acuaggagac       60

agucucgacg acuauguaaa uacccagggu gcauuucuau uuucauuauc aagaaaacaa      120

guagcagcac gaagcgugga agaaugcgca gcuaaaugug aggcugaaac aaauuuuaua      180

uguagagcau uccaauauca uagcaaagau caacaaugcg uuguaauggc cgaaaacuca      240

aaaacaaguc cuaucgcgag aaugagagau guaguacuuu ucgaaaaaag aauuuaucuu      300

agcgaaugua aaaccggaaa uggcaaaaau uacagaggaa caacaucaaa aaccaaaagu      360

gguguuaucu gucaaaaaug gucuguaucu agcccacaua uuccaaaaua uucaccugaa      420

aaauucccgu uagcaggucu agaagagaau uauuguagaa auccugauaa cgaugaaaaa      480

gguccauggu gcuacacgac agaucccgaa acuagauucg auuacuguga uauaccugaa      540

ugcgaagaug aguguaugca cugcucaggu gaacauuacg aaggcaaaau uucaaaaaca      600

augucaggua uagaauguca aucaugggga ucucaaucac cacacgcaca ugguuauuua      660

cccaguaaau ucccaaauaa aaaucuaaaa augaacuauu guagaaaccc ggacggugaa      720

cccagaccau gguguuuuac uacagaucca aacaaaagau gggaauuuug ugauauacca      780

agauguacaa caccuccccc uacaucagga ccuacauauc aauguuuaaa agggagagga      840

gaaaacuaua gagguacagu cucaguaaca gcaaguggac auacauguca aagaugguca      900

gcacaaaguc cccauaaaca uaauagaacu cccgaaaauu ucccuugcaa aaaucuagaa      960

gaaaacuauu gcagaaaccc agacggagaa acagcaccgu ggugcuacac uacagacagu     1020

gaaguaagau gggauuacug uaagauaccu ucauguggaa gcucaacuac aaguacagaa     1080

caccuagacg caccuguucc accugaacaa acuccggucg cacaagauug uuaucgcggu     1140

aauggagaau cauacagggg uacaagcuca acuaccauaa caggcagaaa augccaaagu     1200

uggguaagua ugacuccuca ucgacacgaa aaaaccccag gaaauuuucc aaacgcagga     1260

cugacaauga acuacugcag aaacccagau gccgauaaau ccccauggug uuacacaaca     1320

gauccgagag uacgauggga guauuguaac cuuaaaaaau guagugaaac agaacaacaa     1380

guaacaaauu ucccagcaau ugcacaaguu ccuucuguag aagaccuauc agaagauugu     1440

auguuuggca acggaaaaag auaucgcggu aaaagagcaa caacaguagc aggcguacca     1500

ugucaagaau gggcugcuca agaaccacac cgacauagua uauucacgcc agaaacaaau     1560

cccagagcug gcuuagagaa aaauuauugu agaaauccag auggagacga uaaugggccc     1620

ugguguuaua caacaaaucc ucaaaaacuu uucgauuacu gcgauguacc acaaugcguu     1680

acaucaucau uugacugugg aaaaccaaaa guggaaccua agaaaugucc agcaagagua     1740

guaggaggcu guguaucgau accacacuca uggccauggc agauuagucu aagauauagg     1800

uacagagguc auuucugugg aggaacccua auuaguccag aauggguccu aacagcaaaa     1860

cauugucugg aaaaaucuag cagucccucu agcuacaaag uaauacucgg ugcccacgaa     1920

gaauaucacu uaggagaagg uguccaagaa auugauguau caaaacuauu caaagaacca     1980

agcggcgcag auauagcauu auuaaaacua aguagcccug cagucauaac cgauaaaguc     2040

auaccugcau gucuaccaac cccaaauuau guaguagcag auagaacugc uuguuacaua     2100

acaggcuggg gugaaaccaa aggaacauau ggagccggac uacuaaaaga agccagguua     2160

ccaguaauug aaaauaaagu auguaacaga uaugaauauc uaggaggaaa aguaucacca     2220

aacgaauuau gugcaggaca ccuagcggga ggaauugauu caugccaagg ugauucaggu     2280

ggaccauuag uauguuucga aaaagauaaa uacauauuac aaggaguaac aucauggggu     2340

cugggaugcg cauuaccaaa uaagccaggu guuuauguca gagucucucg cuuuguaacu     2400

uggauagaag aaauaaugag gagaaauuaa                                      2430


<210>  7409
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__P00747

<400>  7409

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  7410
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__AAN85555

<400>  7410
auggaacaua aggaaguggu ucuucuacuu cuuuuauuuc ugaaaucagg ucaaggagag       60

ccucuggaug acuaugugaa uacccagggg gcuucacugu ucagugucac uaagaagcag      120

cugggagcag gaaguauaga agaaugugca gcaaaaugug aggaggacga agaauucacc      180

ugcagggcau uccaauauca caguaaagag caacaaugug ugauaauggc ugaaaacagg      240

aaguccucca uaaucauuag gaugagagau guaguuuuau uugaaaagaa aguguaucuc      300

ucagagugca agacugggaa uggaaagaac uacagaggga cgauguccaa aacaaaaaau      360

ggcaucaccu gucaaaaaug gaguuccacu ucuccccaca gaccuagauu cucaccugcu      420

acacaccccu cagagggacu ggaggagaac uacugcagga auccagacaa cgauccgcag      480

gggcccuggu gcuauacuac ugauccagaa aagagauaug acuacugcga cauucuugag      540

ugugaagagg aauguaugca uugcagugga gaaaacuaug acggcaaaau uuccaagacc      600

augucuggac uggaaugcca ggccugggac ucucagagcc cacacgcuca uggauacauu      660

ccuuccaaau uuccaaacaa gaaccugaag aagaauuacu gucguaaccc cgauagggag      720

cugcggccuu gguguuucac caccgacccc aacaagcgcu gggaacuuug cgacaucccc      780

cgcugcacaa caccuccacc aucuucuggu cccaccuacc agugucugaa gggaacaggu      840

gaaaacuauc gcgggaaugu ggcuguuacc guguccgggc acaccuguca gcacuggagu      900

gcacagaccc cucacacaca uaacaggaca ccagaaaacu uccccugcaa aaauuuggau      960

gaaaacuacu gccgcaaucc ugacggaaaa agggccccau ggugccauac aaccaacagc     1020

caagugcggu gggaguacug uaagauaccg uccugugacu ccuccccagu auccacggaa     1080

caauuggcuc ccacagcacc accugagcua accccugugg uccaggacug cuaccauggu     1140

gauggacaga gcuaccgagg cacauccucc accaccacca caggaaagaa gugucagucu     1200

uggucaucua ugacaccaca ccggcaccag aagaccccag aaaacuaccc aaaugcuggc     1260

cugacaauga acuacugcag gaauccagau gccgauaaag gccccuggug uuuuaccaca     1320

gaccccagcg ucagguggga guacugcaac cugaaaaaau gcucaggaac agaagcgagu     1380

guuguagcac cuccgccugu uguccugcuu ccagauguag agacuccuuc cgaagaagac     1440

uguauguuug ggaaugggaa aggauaccga ggcaagaggg cgaccacugu uacugggacg     1500

ccaugccagg acugggcugc ccaggagccc cauagacaca gcauuuucac uccagagaca     1560

aauccacggg cgggucugga aaaaaauuac ugccguaacc cugaugguga uguagguggu     1620

cccuggugcu acacgacaaa uccaagaaaa cuuuacgacu acugugaugu cccucagugu     1680

gcggccccuu cauuugauug ugggaagccu caaguggagc cgaagaaaug uccuggaagg     1740

guuguagggg gguguguggc ccacccacau uccuggcccu ggcaagucag ucuuagaaca     1800

agguuuggaa ugcacuucug uggaggcacc uugauauccc cagagugggu guugacugcu     1860

gcccacugcu uggagaaguc cccaaggccu ucauccuaca aggucauccu gggugcacac     1920

caagaaguga aucucgaacc gcauguucag gaaauagaag ugucuaggcu guucuuggag     1980

cccacacgaa aagauauugc cuugcuaaag cuaagcaguc cugccgucau cacugacaaa     2040

guaaucccag cuugucugcc auccccaaau uauguggucg cugaccggac cgaauguuuc     2100

aucacuggcu ggggagaaac ccaagguacu uuuggagcug gccuucucaa ggaagcccag     2160

cucccuguga uugagaauaa agugugcaau cgcuaugagu uucugaaugg aagaguccaa     2220

uccaccgaac ucugugcugg gcauuuggcc ggaggcacug acaguugcca gggugacagu     2280

ggagggccuc ugguuugcuu cgagaaggac aaauacauuu uacaaggagu cacuucuugg     2340

ggucuuggcu gugcacgccc caauaagccu ggugucuaug uucguguuuc aagguuuguu     2400

acuuggauug agggagugau gagaaauaau uaa                                  2433


<210>  7411
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7411
auggagcaca aggagguggu ccugcuccug cugcuguucc ucaagagcgg ccagggggag       60

ccccuggacg acuacgugaa cacccagggc gccucccucu ucagcgugac caagaagcag      120

cugggggccg gcuccaucga ggagugcgcg gccaagugcg aggaggacga ggaguucacg      180

ugccgcgccu uccaguacca cagcaaggag cagcagugcg ucaucauggc cgagaaccgg      240

aaguccagca ucaucauccg caugcgggac guggugcugu ucgagaagaa ggucuaccuc      300

uccgagugca agaccgggaa cggcaagaac uaccgcggca ccaugagcaa gaccaagaac      360

gggaucacgu gccagaagug guccagcacc uccccgcacc ggccccgcuu cagccccgcc      420

acccaccccu ccgagggccu ggaggagaac uacugccgga acccggacaa cgacccccag      480

gggcccuggu gcuacaccac ggaccccgag aagcgcuacg acuacugcga cauccuggag      540

ugcgaggagg agugcaugca cugcagcggc gagaacuacg acgggaagau cuccaagacc      600

augagcggcc ucgagugcca ggcgugggac ucccagagcc cgcacgccca cggcuacauc      660

cccuccaagu uccccaacaa gaaccugaag aagaacuacu gccggaaccc cgaccgcgag      720

cugcggccgu ggugcuucac caccgacccc aacaagcgcu gggagcucug cgacaucccc      780

cggugcacga cgcccccgcc cagcagcggg cccaccuacc agugccucaa gggcaccggg      840

gagaacuacc gcggcaacgu ggccgugacc gucuccggcc acacgugcca gcacuggagc      900

gcccagacgc cccacaccca caaccggacc ccggagaacu uccccugcaa gaaccuggac      960

gagaacuacu gccgcaaccc cgacgggaag cgggcgcccu ggugccacac caccaacucc     1020

caggugcgcu gggaguacug caagaucccg agcugcgacu ccagccccgu guccaccgag     1080

cagcuggccc ccaccgcgcc cccggagcug acccccgucg ugcaggacug cuaccacggc     1140

gacgggcaga gcuaccgggg caccuccagc accacgacca ccgggaagaa gugccagucc     1200

uggagcucca ugacgcccca ccgccaccag aagaccccgg agaacuaccc caacgccggc     1260

cugaccauga acuacugccg gaaccccgac gccgacaagg gccccuggug cuucaccacc     1320

gacccgagcg ugcgcuggga guacugcaac cucaagaagu gcuccgggac ggaggccagc     1380

gucguggccc cgccgcccgu gguccugcug cccgacgugg agacccccuc cgaggaggac     1440

ugcauguucg gcaacgggaa gggcuaccgc gggaagcggg ccaccaccgu gaccggcacg     1500

cccugccagg acugggccgc ccaggagccc caccgccaca gcaucuucac ccccgagacc     1560

aacccccggg cgggccucga gaagaacuac ugccgcaacc ccgacgggga cgucggcggg     1620

cccuggugcu acaccacgaa cccgcggaag cuguacgacu acugcgacgu gccccagugc     1680

gccgcccccu ccuucgacug cggcaagccc cagguggagc cgaagaagug ccccgggcgc     1740

gucgugggcg gcugcgucgc ccacccccac agcuggcccu ggcaggucag ccugcggacc     1800

cgcuucggga ugcacuucug cggcgggacc cucaucuccc cggagugggu gcugaccgcc     1860

gcgcacugcc uggagaaguc cccgcggccc agcagcuaca aggugauccu cggcgcccac     1920

caggagguga accuggagcc ccacgugcag gagaucgagg ucucccgccu guuccucgag     1980

cccacgcgga aggacaucgc ccugcugaag cucagcuccc ccgccgugau caccgacaag     2040

gugauccccg ccugccugcc gagccccaac uacgucgugg cggaccgcac cgagugcuuc     2100

aucaccggcu ggggcgagac gcaggggacc uucggggccg gccugcucaa ggaggcccag     2160

cugcccguga ucgagaacaa ggucugcaac cgguacgagu uccugaacgg gcgcgugcag     2220

uccaccgagc ucugcgccgg ccaccuggcg ggcgggaccg acagcugcca gggcgacucc     2280

gggggccccc uggugugcuu cgagaaggac aaguacaucc uccagggggu cacgagcugg     2340

ggccugggcu gcgcccggcc gaacaagccc gggguguacg ugcgcgucuc ccgguucgug     2400

accuggaucg agggcgugau gcgcaacaac uga                                  2433


<210>  7412
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7412
auggagcaca aggaggucgu ccuccuccuc cuccucuucc ucaaguccgg ccagggcgag       60

ccccucgacg acuacgucaa cacccagggc gccucccucu ucuccgucac caagaagcag      120

cucggcgccg gcuccaucga ggagugcgcc gccaagugcg aggaggacga ggaguucacc      180

ugccgcgccu uccaguacca cuccaaggag cagcagugcg ucaucauggc cgagaaccgc      240

aaguccucca ucaucauccg caugcgcgac gucguccucu ucgagaagaa ggucuaccuc      300

uccgagugca agaccggcaa cggcaagaac uaccgcggca ccauguccaa gaccaagaac      360

ggcaucaccu gccagaagug guccuccacc uccccccacc gcccccgcuu cucccccgcc      420

acccaccccu ccgagggccu cgaggagaac uacugccgca accccgacaa cgacccccag      480

ggccccuggu gcuacaccac cgaccccgag aagcgcuacg acuacugcga cauccucgag      540

ugcgaggagg agugcaugca cugcuccggc gagaacuacg acggcaagau cuccaagacc      600

auguccggcc ucgagugcca ggccugggac ucccaguccc cccacgccca cggcuacauc      660

cccuccaagu uccccaacaa gaaccucaag aagaacuacu gccgcaaccc cgaccgcgag      720

cuccgccccu ggugcuucac caccgacccc aacaagcgcu gggagcucug cgacaucccc      780

cgcugcacca cccccccccc cuccuccggc cccaccuacc agugccucaa gggcaccggc      840

gagaacuacc gcggcaacgu cgccgucacc gucuccggcc acaccugcca gcacuggucc      900

gcccagaccc cccacaccca caaccgcacc cccgagaacu uccccugcaa gaaccucgac      960

gagaacuacu gccgcaaccc cgacggcaag cgcgcccccu ggugccacac caccaacucc     1020

cagguccgcu gggaguacug caagaucccc uccugcgacu ccucccccgu cuccaccgag     1080

cagcucgccc ccaccgcccc ccccgagcuc acccccgucg uccaggacug cuaccacggc     1140

gacggccagu ccuaccgcgg caccuccucc accaccacca ccggcaagaa gugccagucc     1200

ugguccucca ugacccccca ccgccaccag aagacccccg agaacuaccc caacgccggc     1260

cucaccauga acuacugccg caaccccgac gccgacaagg gccccuggug cuucaccacc     1320

gaccccuccg uccgcuggga guacugcaac cucaagaagu gcuccggcac cgaggccucc     1380

gucgucgccc ccccccccgu cguccuccuc cccgacgucg agacccccuc cgaggaggac     1440

ugcauguucg gcaacggcaa gggcuaccgc ggcaagcgcg ccaccaccgu caccggcacc     1500

cccugccagg acugggccgc ccaggagccc caccgccacu ccaucuucac ccccgagacc     1560

aacccccgcg ccggccucga gaagaacuac ugccgcaacc ccgacggcga cgucggcggc     1620

cccuggugcu acaccaccaa cccccgcaag cucuacgacu acugcgacgu cccccagugc     1680

gccgcccccu ccuucgacug cggcaagccc caggucgagc ccaagaagug ccccggccgc     1740

gucgucggcg gcugcgucgc ccacccccac uccuggcccu ggcaggucuc ccuccgcacc     1800

cgcuucggca ugcacuucug cggcggcacc cucaucuccc ccgagugggu ccucaccgcc     1860

gcccacugcc ucgagaaguc cccccgcccc uccuccuaca aggucauccu cggcgcccac     1920

caggagguca accucgagcc ccacguccag gagaucgagg ucucccgccu cuuccucgag     1980

cccacccgca aggacaucgc ccuccucaag cucuccuccc ccgccgucau caccgacaag     2040

gucauccccg ccugccuccc cucccccaac uacgucgucg ccgaccgcac cgagugcuuc     2100

aucaccggcu ggggcgagac ccagggcacc uucggcgccg gccuccucaa ggaggcccag     2160

cuccccguca ucgagaacaa ggucugcaac cgcuacgagu uccucaacgg ccgcguccag     2220

uccaccgagc ucugcgccgg ccaccucgcc ggcggcaccg acuccugcca gggcgacucc     2280

ggcggccccc ucgucugcuu cgagaaggac aaguacaucc uccagggcgu caccuccugg     2340

ggccucggcu gcgcccgccc caacaagccc ggcgucuacg uccgcgucuc ccgcuucguc     2400

accuggaucg agggcgucau gcgcaacaac uga                                  2433


<210>  7413
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7413
auggagcaca aggaaguggu ccugcuccuu cuguuguucu uaaaaagcgg ccagggggag       60

ccccuggacg auuacguuaa cacccaagga gccucccuau uuucugugac aaagaaacag      120

cucggugcug gcucaaucga agagugcgca gccaagugug aagaggacga ggaguucacu      180

ugcagagcgu uucaguauca uaguaaagaa cagcaaugug uaauuauggc ugaaaauagg      240

aaaagcucca uaaucauucg gaugcgcgau gugguccugu ucgagaagaa aguguaccuu      300

ucugagugca agacggggaa cggaaagaau uaucgaggca ccaugucgaa gaccaaaaac      360

gguaucacuu gucagaagug gucaagcacc aguccucacc guccaagauu uuccccggcc      420

acacaucccu cugaagggcu ggaggaaaau uacugcagga acccugacaa ugauccacag      480

ggacccuggu guuauaccac ugacccugag aagcgguacg auuauugcga cauuuuggaa      540

ugugaggagg aaugcaugca cuguagcggc gagaacuacg auggcaaaau cuccaagaca      600

augucagggc ucgaaugcca ggcaugggac agucaaagcc cacaugccca cggauacaua      660

cccucuaaau ucccuaauaa gaaccugaaa aagaauuauu gccgcaaccc agauagagag      720

cugaggccgu gguguuuuac cacggacccc aauaaacggu gggaacucug cgauaucccu      780

cgcuguacua ccccaccccc uuccucaggu ccaacauacc agugcuuaaa gggcacuggg      840

gagaacuauc gaggaaaugu ugcugugacc gucagcggcc acacauguca gcauuggagu      900

gcacagacac cccacacgca uaacagaacu ccggagaacu ucccuugcaa gaaucuggac      960

gaaaacuacu guaggaaucc cgacgguaaa cgggccccau ggugccacac aaccaacucu     1020

caagugcguu gggaguauug uaagauuccu uccugcgaua gcucgcccgu aucuacugaa     1080

cagcuugcuc caacagcccc uccugaguug accccaguug ugcaggacug uuaccacggg     1140

gauggacaau ccuaucgcgg cacgucaagu accacaacua ccggcaaaaa gugccagagc     1200

ugguccucua ugacaccgca uagacaccag aaaacucccg aaaauuaccc uaacgcgggg     1260

cugaccauga auuacugcag gaacccagac gcagauaagg gacccuggug uuuuacaacc     1320

gacccuagcg uccgguggga guauugcaau cuaaagaaau guucagguac ugaggccagu     1380

gugguggcuc cacccccggu cguucuccug ccugaugugg aaacgccauc cgaggaagac     1440

ugcauguucg gcaacgggaa gggauaccga ggcaaacgcg ccacaaccgu aacugguacc     1500

cccugucagg auugggcagc ucaagagccu cauagacaca gcaucuuuac acccgagacc     1560

aauccaaggg ccgggcuuga aaagaacuau ugccggaauc cugacggcga ugugggaggc     1620

cccugguguu acacuacaaa cccacgcaaa cuguaugacu acugcgacgu cccgcagugu     1680

gcggccccuu cuuucgauug cgggaagccc cagguggagc caaagaaaug ucccggaaga     1740

guugugggug gcugcgucgc acauccucac ucauggccau ggcaagugag uuugaggacg     1800

cguuuuggga ugcacuucug cggaggcacc cucauuagcc ccgaaugggu acugacugcu     1860

gcccauuguu uagagaaguc cccucggccg ucuucguaua aaguuauccu gggugcucac     1920

caggaaguga aucucgagcc acauguccag gagauagaag ugagccgacu uuuccuggag     1980

cccacaagaa aggacauugc cuugcuaaaa cuguccucac ccgcagucau caccgauaag     2040

gugauuccag ccugccuccc caguccuaac uacguugugg cugacaggac agaauguuuu     2100

aucacugggu ggggcgagac ccagggaacg uucggcgcgg ggcugcuuaa ggaagcacag     2160

cugccgguaa ucgagaacaa agucugcaau cgcuacgagu uuuugaacgg acgggugcaa     2220

ucuaccgaac ucugugccgg ucaccuggcu ggcgggacag auagcugcca gggagacucc     2280

ggcggucccu uaguuuguuu cgagaaggau aaauauauuc ugcagggggu gacuucaugg     2340

ggccuaggau gcgccagacc aaauaagccu ggcgucuacg ugaggguaag ccgcuuugug     2400

accuggauag aagggguuau gcgaaacaau uga                                  2433


<210>  7414
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7414
auggagcaca aggagguggu gcugcugcug cugcuguucc ugaagagcgg ccagggcgag       60

ccccuggacg acuacgugaa cacccagggc gccagccugu ucagcgugac caagaagcag      120

cugggcgccg gcagcaucga ggagugcgcc gccaagugcg aggaggacga ggaguucacc      180

ugcagagccu uccaguacca cagcaaggag cagcagugcg ugaucauggc cgagaacaga      240

aagagcagca ucaucaucag aaugagagac guggugcugu ucgagaagaa gguguaccug      300

agcgagugca agaccggcaa cggcaagaac uacagaggca ccaugagcaa gaccaagaac      360

ggcaucaccu gccagaagug gagcagcacc agcccccaca gacccagauu cagccccgcc      420

acccacccca gcgagggccu ggaggagaac uacugcagaa accccgacaa cgacccccag      480

ggccccuggu gcuacaccac cgaccccgag aagagauacg acuacugcga cauccuggag      540

ugcgaggagg agugcaugca cugcagcggc gagaacuacg acggcaagau cagcaagacc      600

augagcggcc uggagugcca ggccugggac agccagagcc cccacgccca cggcuacauc      660

cccagcaagu uccccaacaa gaaccugaag aagaacuacu gcagaaaccc cgacagagag      720

cugagacccu ggugcuucac caccgacccc aacaagagau gggagcugug cgacaucccc      780

agaugcacca cccccccccc cagcagcggc cccaccuacc agugccugaa gggcaccggc      840

gagaacuaca gaggcaacgu ggccgugacc gugagcggcc acaccugcca gcacuggagc      900

gcccagaccc cccacaccca caacagaacc cccgagaacu uccccugcaa gaaccuggac      960

gagaacuacu gcagaaaccc cgacggcaag agagcccccu ggugccacac caccaacagc     1020

caggugagau gggaguacug caagaucccc agcugcgaca gcagccccgu gagcaccgag     1080

cagcuggccc ccaccgcccc ccccgagcug acccccgugg ugcaggacug cuaccacggc     1140

gacggccaga gcuacagagg caccagcagc accaccacca ccggcaagaa gugccagagc     1200

uggagcagca ugacccccca cagacaccag aagacccccg agaacuaccc caacgccggc     1260

cugaccauga acuacugcag aaaccccgac gccgacaagg gccccuggug cuucaccacc     1320

gaccccagcg ugagauggga guacugcaac cugaagaagu gcagcggcac cgaggccagc     1380

gugguggccc ccccccccgu ggugcugcug cccgacgugg agacccccag cgaggaggac     1440

ugcauguucg gcaacggcaa gggcuacaga ggcaagagag ccaccaccgu gaccggcacc     1500

cccugccagg acugggccgc ccaggagccc cacagacaca gcaucuucac ccccgagacc     1560

aaccccagag ccggccugga gaagaacuac ugcagaaacc ccgacggcga cgugggcggc     1620

cccuggugcu acaccaccaa ccccagaaag cuguacgacu acugcgacgu gccccagugc     1680

gccgccccca gcuucgacug cggcaagccc cagguggagc ccaagaagug ccccggcaga     1740

guggugggcg gcugcguggc ccacccccac agcuggcccu ggcaggugag ccugagaacc     1800

agauucggca ugcacuucug cggcggcacc cugaucagcc ccgagugggu gcugaccgcc     1860

gcccacugcc uggagaagag ccccagaccc agcagcuaca aggugauccu gggcgcccac     1920

caggagguga accuggagcc ccacgugcag gagaucgagg ugagcagacu guuccuggag     1980

cccaccagaa aggacaucgc ccugcugaag cugagcagcc ccgccgugau caccgacaag     2040

gugauccccg ccugccugcc cagccccaac uacguggugg ccgacagaac cgagugcuuc     2100

aucaccggcu ggggcgagac ccagggcacc uucggcgccg gccugcugaa ggaggcccag     2160

cugcccguga ucgagaacaa ggugugcaac agauacgagu uccugaacgg cagagugcag     2220

agcaccgagc ugugcgccgg ccaccuggcc ggcggcaccg acagcugcca gggcgacagc     2280

ggcggccccc uggugugcuu cgagaaggac aaguacaucc ugcagggcgu gaccagcugg     2340

ggccugggcu gcgccagacc caacaagccc ggcguguacg ugagagugag cagauucgug     2400

accuggaucg agggcgugau gagaaacaac uga                                  2433


<210>  7415
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7415
auggagcaca aggaaguggu ccugcuccug cuucuguucc ucaaaagcgg ccagggggag       60

ccccuggacg auuacguuaa cacccaagga gccucccucu uuucugugac aaagaaacag      120

cugggcgcug ggagcaucga agagugcgcc gcgaagugug aagaggacga ggaguucacg      180

ugcagagcuu uucaguauca uuccaaagag cagcaaugug ugauuauggc cgaaaaucgg      240

aagucuagca ucauuauccg caugagagau gucgugcuuu ucgagaagaa aguuuaccug      300

uccgagugca agaccggaaa cggcaaaaau uaucggggga caaugucuaa gaccaaaaac      360

ggaauuacau gucagaagug gagcuccacc agcccucacc gcccgagauu uucucccgcc      420

acacauccuu ccgaaggccu ggaggaaaau uacugccgga accccgacaa ugauccucag      480

ggccccuggu guuauaccac ggacccugag aagcgcuacg auuauugcga cauccucgaa      540

ugugaggagg aaugcaugca cuguagcggg gagaacuacg auggaaaaau cucuaagacc      600

auguccggcc uggaaugcca ggcuugggac agccaaucuc cgcaugccca cggguacauu      660

cccuccaaau ucccuaauaa gaaccuuaaa aagaauuauu gcagaaaccc cgaucgggag      720

cugcgcccuu gguguuuuac aaccgacccc aauaaaagau gggaacucug cgauaucccg      780

cgguguacaa ccccuccccc uagcuccgga cccacguacc agugccugaa gggcacaggg      840

gagaacuauc gcggaaaugu ggcugucacc gugucuggcc acacauguca gcauuggagc      900

gcccagacac cccacaccca uaacagaacc ccugagaacu ucccgugcaa gaaucuugac      960

gaaaacuacu gucggaaucc cgacggcaaa cgcgcgccuu ggugccacac gaccaacucc     1020

caaguuagau gggaguauug uaagauuccc agcugcgauu cuuccccugu gagcacagaa     1080

cagcuggccc ccaccgcucc gccugagcuc acacccgucg ugcaggacug uuaccacggg     1140

gauggacaau cuuaucgggg caccagcucc acgacaacca ccgggaaaaa gugccagucu     1200

uggagcucca ugacaccuca uagacaccag aaaacccccg aaaauuaccc uaacgccgga     1260

cugacaauga auuacugccg caaccccgac gcugauaagg gcccguggug uuuuacgacc     1320

gacccuagcg ugcgguggga guauugcaau cugaagaaau guucugggac agaggccucc     1380

gucguugcgc ccccucccgu ggugcuccug ccggaugucg aaacccccag cgaggaagac     1440

ugcauguucg gaaacggcaa gggcuacaga gggaaacgcg ccacaaccgu gacgggaacc     1500

ccuugucagg auugggcugc ccaagagccc caucggcacu cuaucuuuac accugagacc     1560

aaucccagag cuggccuuga aaagaacuau ugccgcaauc cugacgggga uguuggaggc     1620

cccugguguu acacaaccaa cccgcggaaa cuguaugacu acugcgacgu gccucagugu     1680

gccgcccccu ccuucgauug cgggaagccu caggucgagc ccaagaaaug uccgggcaga     1740

gugguuggag gcugcguggc ucauccucac agcuggcccu ggcaggucuc ccuccgcacg     1800

cgguuuggga ugcacuucug cggaggcaca cugauuucuc cugaaugggu gcuuaccgcg     1860

gcccauuguc uggaaaagag ccccagaccc uccucuuaua aagucauccu cggggcucac     1920

caagaaguga aucuggagcc ucauguucag gagauugaag ugagccgccu guuccucgag     1980

ccgacacgga aggacaucgc ccugcuuaaa cuguccagcc ccgccgucau caccgauaag     2040

gugauuccug cuugccuccc cucuccuaac uacguugugg ccgacagaac cgaauguuuu     2100

aucacaggau ggggcgagac gcaggggacc uucggcgcgg gacugcuuaa ggaagcucag     2160

cugcccguca uugagaacaa agugugcaau cgguacgagu uucucaacgg ccgcgugcaa     2220

uccacagaac ugugugccgg gcaccuggcc ggaggcaccg auagcugcca gggggacucu     2280

ggaggcccuc ucguuuguuu cgagaaggau aaauauaucc ugcagggggu cacauccugg     2340

ggccuuggau gcgcuagacc gaauaagccc ggcguguacg ugcgggucag cagauuugug     2400

accuggauug aagggguuau gcgcaacaau uga                                  2433


<210>  7416
<211>  2433
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Angiostatin__Homo_sapiens__AAN85555

<400>  7416
auggaacaua aagaaguugu auuauuacua uuauuauuuu uaaaaucugg ucaaggagaa       60

ccauuagacg auuauguaaa uacccaggga gcuucauuau ucagugucac gaaaaaacaa      120

cuuggagcag gcucaauaga agaaugcgcu gcuaaaugcg aagaagacga agaauuuaca      180

ugcagggcau uucaauauca uagcaaagaa caacaaugug uaaucauggc agaaaaucga      240

aaaucuucaa uaauaauaag aaugagagau guaguauuau ucgaaaaaaa aguauacuua      300

uccgaaugca aaaccggaaa cggaaaaaau uacagaggaa caaugaguaa aacuaaaaac      360

gguauuacau gucaaaaaug gucuaguacc ucaccacaua gacccagauu uaguccagca      420

acacacccau cagaaggccu agaagaaaau uacugcagaa aucccgauaa ugacccucaa      480

ggcccuuggu gcuacacaac ugacccugaa aaacgauacg auuauugcga cauacucgaa      540

ugcgaagaag aauguaugca uugcuccgga gaaaacuaug augguaaaau aucaaagaca      600

augucugggu uagaaugcca agcaugggau ucacaauccc cucaugcaca uggauauaua      660

ccaaguaaau ucccuaacaa aaaucuaaag aaaaacuacu guagaaaucc agacagagag      720

uuaagaccau gguguuuuac uacagauccu aauaaaagau gggaauuaug cgauauaccu      780

agaugcacaa caccaccucc caguucuggu ccaacuuacc aaugcuuaaa aggaacaggu      840

gaaaacuaca gagguaaugu agcuguuaca guaucaggac auacauguca acacuggagc      900

gcucaaacuc cacauacuca uaacagaaca ccugaaaauu uuccuuguaa aaaucuagau      960

gaaaauuauu guaggaaucc cgauggaaaa cgagcuccgu ggugucacac aaccaauuca     1020

caagugagau gggaauauug caaaauaccg ucaugugauu cauccccagu aucuacugaa     1080

caacuagcgc cuacagcccc cccagaauua acuccagucg uacaagauug uuaucacgga     1140

gaugggcaau cauacagagg aacaucaagu acaacaacca ccggcaaaaa augucaauca     1200

uggucuucaa ugaccccgca uagacaucaa aagacgccag aaaauuaccc aaaugccgga     1260

uuaaccauga auuauugcag aaaucccgau gcugauaaag guccauggug cuucacaaca     1320

gauccaucag uacgauggga auacuguaau cuaaagaaau gcaguggaac cgaagccucg     1380

guuguagcac caccaccagu gguauuacua ccugauguug aaacaccuag cgaagaagau     1440

uguauguuug gaaauggaaa aggcuaucga ggaaaaagag cgacaacugu aacaggaacu     1500

ccgugucaag auugggcugc acaggaacca cauagacacu caauuuuuac accugaaaca     1560

aauccaagag caggcuuaga aaaaaauuac uguagaaacc cugacgguga uguaggagga     1620

ccaugguguu auacaacuaa uccucgaaaa cuauacgacu acugugacgu uccucaaugc     1680

gcugcucccu cauucgacug uggaaaacca caaguagaac caaaaaaaug uccaggcaga     1740

guagucggag guugcguagc acacccgcac ucauggccuu ggcaaguauc auuaagaaca     1800

agauuuggca ugcacuuuug uggugggaca uuaauauccc cagaaugggu auuaacagcu     1860

gcccauugcu uagagaaauc uccaagacca ucaucauaca aggugauauu aggugcacau     1920

caagaaguaa aucucgagcc acacgugcaa gagauagaag uaaguagacu auuuuuagaa     1980

ccaacaagaa aagauauagc acuauuaaaa cucucuucgc cagccgucau uaccgauaaa     2040

guuauaccug cuuguuuacc aagucccaau uauguagucg cagauagaac ugaauguuuu     2100

auuacaggau ggggggaaac acaagguacu uuuggugcug ggcuacuuaa agaagcucaa     2160

cuuccaguua uagaaaauaa aguauguaau cgauaugaau uucuuaaugg aagaguacaa     2220

ucaacagaau uaugcgcagg ucaucuagca ggcggaacag acucaugcca aggagacagu     2280

ggcgguccac ucguauguuu ugaaaaagau aaauauauac uucaaggugu cacaucaugg     2340

ggauugggau gugcucgacc aaauaaacca gguguauaug ucagaguauc cagauucgua     2400

acauggauag aaggugucau gagaaauaac uaa                                  2433


<210>  7417
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__Q5TEH5

<400>  7417

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg 
    130                 135     


<210>  7418
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Angiostatin__Homo_sapiens__EAW47592

<400>  7418
auggaacaua aggaaguggu ucuucuacuu cuuuuauuuc ugaaaucagg ucaaggagag       60

ccucuggaug acuaugugaa uacccagggg gcuucacugu ucagugucac uaagaagcag      120

cugggagcag gaaguauaga agaaugugca gcaaaaugug aggaggacga agaauucacc      180

ugcagggcau uccaauauca caguaaagag caacaaugug ugauaauggc ugaaaacagg      240

aaguccucca uaaucauuag gaugagagau guaguuuuau uugaaaagaa aguguaucuc      300

ucagagugca agacugggaa uggaaagaac uacagaggga cgauguccaa aacaaaaaau      360

ggcaucaccu gucaaaaaug gaguuccacu ucuccccaca gaccuaggua a               411


<210>  7419
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7419
auggagcaca aggagguggu ccugcuccug cugcuguucc ucaagagcgg ccagggggag       60

ccccuggacg acuacgugaa cacccagggc gccucccucu ucagcgugac caagaagcag      120

cugggggccg gcuccaucga ggagugcgcg gccaagugcg aggaggacga ggaguucacg      180

ugccgcgccu uccaguacca cagcaaggag cagcagugcg ucaucauggc cgagaaccgg      240

aaguccagca ucaucauccg caugcgggac guggugcugu ucgagaagaa ggucuaccuc      300

uccgagugca agaccgggaa cggcaagaac uaccgcggca ccaugagcaa gaccaagaac      360

gggaucacgu gccagaagug guccagcacc uccccgcacc ggccccgcug a               411


<210>  7420
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7420
auggagcaca aggaggucgu ccuccuccuc cuccucuucc ucaaguccgg ccagggcgag       60

ccccucgacg acuacgucaa cacccagggc gccucccucu ucuccgucac caagaagcag      120

cucggcgccg gcuccaucga ggagugcgcc gccaagugcg aggaggacga ggaguucacc      180

ugccgcgccu uccaguacca cuccaaggag cagcagugcg ucaucauggc cgagaaccgc      240

aaguccucca ucaucauccg caugcgcgac gucguccucu ucgagaagaa ggucuaccuc      300

uccgagugca agaccggcaa cggcaagaac uaccgcggca ccauguccaa gaccaagaac      360

ggcaucaccu gccagaagug guccuccacc uccccccacc gcccccgcug a               411


<210>  7421
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7421
auggagcaca aggaaguggu ccugcuccuu cuguuguucu uaaaaagcgg ccagggggag       60

ccccuggacg auuacguuaa cacccaagga gccucccuau uuucugugac aaagaaacag      120

cucggugcug gcucaaucga agagugcgca gccaagugug aagaggacga ggaguucacu      180

ugcagagcgu uucaguauca uaguaaagaa cagcaaugug uaauuauggc ugaaaauagg      240

aaaagcucca uaaucauucg gaugcgcgau gugguccugu ucgagaagaa aguguaccuu      300

ucugagugca agacggggaa cggaaagaau uaucgaggca ccaugucgaa gacuaaaaac      360

gguaucacau gucagaagug gucaagcacc aguccucacc guccaagaug a               411


<210>  7422
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7422
auggagcaca aggagguggu gcugcugcug cugcuguucc ugaagagcgg ccagggcgag       60

ccccuggacg acuacgugaa cacccagggc gccagccugu ucagcgugac caagaagcag      120

cugggcgccg gcagcaucga ggagugcgcc gccaagugcg aggaggacga ggaguucacc      180

ugcagagccu uccaguacca cagcaaggag cagcagugcg ugaucauggc cgagaacaga      240

aagagcagca ucaucaucag aaugagagac guggugcugu ucgagaagaa gguguaccug      300

agcgagugca agaccggcaa cggcaagaac uacagaggca ccaugagcaa gaccaagaac      360

ggcaucaccu gccagaagug gagcagcacc agcccccaca gacccagaug a               411


<210>  7423
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7423
auggagcaca aggaaguggu ccugcuccug cuucuguucc ucaaaagcgg ccagggggag       60

ccccuggacg auuacguuaa cacccaagga gccucccuuu ucucugugac aaagaaacag      120

cugggcgcug ggagcaucga agagugcgcc gcgaagugug aagaggacga ggaauuuacg      180

ugcagagcuu uucaguauca uuccaaagag cagcaaugug ugauuauggc cgaaaaucgg      240

aagucuagca ucauuauccg caugagagau gucguucucu ucgagaagaa aguguaccug      300

uccgagugca agaccggaaa cggcaaaaau uaucggggga caaugucuaa gaccaaaaac      360

ggaauuacau gucagaagug gagcuccacc agcccucacc gcccgagaug a               411


<210>  7424
<211>  411
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Angiostatin__Homo_sapiens__EAW47592

<400>  7424
auggaacaca aagaaguagu acuacuacua cuauuauucc uaaaaucagg acaaggagaa       60

ccacuagacg acuacguaaa cacacaagga gcaucacuau ucagcguaac aaaaaaacaa      120

cuaggagcag gaagcauaga agaaugcgca gcaaaaugcg aagaagacga agaauucaca      180

ugcagagcau uccaauacca cucaaaagaa caacaaugcg uaauaauggc agaaaacaga      240

aaaagcagca uaauaauaag aaugagagac guaguauuau ucgaaaaaaa aguauaccua      300

agcgaaugca aaacaggaaa cggaaaaaac uacagaggaa caaugucaaa aacaaaaaac      360

ggaauaacau gccaaaaaug gucaagcaca agcccacaca gaccaagaua a               411


<210>  7425
<211>  1712
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Canstatin__Homo_sapiens__P08572

<400>  7425

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys 
        995                 1000                1005            


Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro Gly 
    1010                1015                1020                


Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly 
1025                1030                1035                1040


Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro 
                1045                1050                1055    


Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly Asp Lys 
            1060                1065                1070        


Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile Gly Ala Thr Gly 
        1075                1080                1085            


Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro Gly Arg Pro Gly 
    1090                1095                1100                


Leu Lys Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe 
1105                1110                1115                1120


Phe Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr 
                1125                1130                1135    


Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln Thr Gly 
            1140                1145                1150        


Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg 
        1155                1160                1165            


Ile Gly Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro 
    1170                1175                1180                


Gly Leu Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly 
1185                1190                1195                1200


Leu Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His 
                1205                1210                1215    


Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly 
            1220                1225                1230        


Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly 
        1235                1240                1245            


Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly Leu 
    1250                1255                1260                


Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala Pro 
1265                1270                1275                1280


Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly 
                1285                1290                1295    


Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly Asp 
            1300                1305                1310        


Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys Gly Trp Ala 
        1315                1320                1325            


Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly Val Phe Gly Leu Pro Gly 
    1330                1335                1340                


Glu Lys Gly Pro Arg Gly Glu Gln Gly Phe Met Gly Asn Thr Gly Pro 
1345                1350                1355                1360


Thr Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro 
                1365                1370                1375    


Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala Gly 
            1380                1385                1390        


Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly Pro Gln Gly 
        1395                1400                1405            


Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro 
    1410                1415                1420                


Pro Gly Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln 
1425                1430                1435                1440


Gly Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly 
                1445                1450                1455    


Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg 
            1460                1465                1470        


Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile 
        1475                1480                1485            


Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met Cys 
    1490                1495                1500                


Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe 
1505                1510                1515                1520


Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser 
                1525                1530                1535    


Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly 
            1540                1545                1550        


Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser 
        1555                1560                1565            


Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile Lys 
    1570                1575                1580                


Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile 
1585                1590                1595                1600


Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp 
                1605                1610                1615    


Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly 
            1620                1625                1630        


Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu 
        1635                1640                1645            


Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr 
    1650                1655                1660                


Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro 
1665                1670                1675                1680


Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly 
                1685                1690                1695    


Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu 
            1700                1705                1710        






<210>  7426
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Canstatin__Homo_sapiens__CCDS41907.1

<400>  7426
auggggagag accagcgcgc gguggccggc ccugcccuac ggcgguggcu gcugcugggg       60

acagugaccg ugggguuccu cgcccagagc gucuuggcgg gugugaagaa guuugaugug      120

ccguguggag gaagagauug cagugggggc ugccagugcu acccugagaa agguggacgu      180

ggucagccug ggccaguggg cccccagggg uacaaugggc caccaggauu acaaggauuc      240

ccgggacugc agggacguaa aggagacaag ggugaaaggg gagcccccgg aguaacggga      300

cccaagggcg acgugggagc aagaggcguu ucuggauucc cuggugccga uggaauuccu      360

ggacacccgg ggcaaggugg gcccagggga aggccgggcu acgauggcug caacggaacc      420

cagggagacu cagguccaca ggggcccccc ggcucugagg gguucaccgg gccucccggg      480

ccccaaggac caaaagggca gaaaggugag ccuuaugcac ugccuaaaga ggagcgcgac      540

agauaucggg gugaaccugg agagccugga uuggucgguu uccagggacc ucccggccgc      600

ccugggcaug ugggacagau ggguccaguu ggagcuccag ggagaccagg accaccugga      660

cccccuggac caaaaggaca gcaaggcaac agaggacuug guuucuacgg aguuaagggu      720

gaaaagggug acguagggca gccgggaccc aacgggauuc caucagacac ccuccacccc      780

aucaucgcgc ccacaggagu caccuuccac ccagaucagu acaaggguga aaaaggcagu      840

gagggggaac caggaauaag aggcauuucc uugaagggag aagaaggaau caugggcuuu      900

ccuggacuga gggguuaccc uggcuugagu ggugaaaaag gaucaccagg acagaaggga      960

agccgaggcc uggauggcua ucaagggccu gauggacccc ggggacccaa gggagaagcc     1020

ggagacccag ggcccccugg acuaccugcc uacuccccuc acccuucccu agcaaaaggu     1080

gccagaggug acccgggauu cccaggggcc caaggggagc caggaagcca gggugagcca     1140

ggagacccgg gccucccagg ucccccuggc cucuccaucg gagauggaga ucagaggaga     1200

ggccugccgg gugagauggg acccaagggc uucaucggag accccggcau cccugcgcuc     1260

uacgggggcc caccuggacc ugauggaaag cgagggccuc caggaccccc cgggcucccu     1320

ggaccaccug gaccugaugg cuuccuguuu gggcugaaag gagcaaaagg aagagcaggc     1380

uucccugggc uucccggcuc cccuggagcc cgcggaccaa agggguggaa aggugacgcu     1440

ggggaaugca gauguacaga aggcgacgaa gcuaucaaag gucuuccggg acugccagga     1500

cccaagggcu ucgcaggcau caacggggag ccggggagga aaggggacag aggagacccc     1560

ggccaacacg gccucccugg guucccaggg cucaagggag ugccuggcaa cauuggugcu     1620

cccggaccca aaggagcaaa aggagauucc agaacaauca caaccaaagg ugagcgggga     1680

cagcccggcg ucccaggugu gcccgggaug aaaggugacg auggcagccc aggccgcgau     1740

gggcucgaug gauuccccgg ccucccaggc ccucccggug auggcaucaa gggcccucca     1800

ggggacccag gcuauccagg aauaccugga acgaagggua cuccaggaga aaugggcccc     1860

ccaggacugg gccuucccgg ccucaaaggc caacgugguu ucccuggaga cgccggcuua     1920

ccuggaccac caggcuuccu gggcccuccu ggccccgcag ggaccccagg acaaauagau     1980

ugugacacag augugaaaag ggccguugga ggugacagac aggaggccau ccagccaggu     2040

ugcauaggag ggcccaaggg auugccaggc cugccaggac ccccaggccc cacaggugcc     2100

aaaggccucc gaggaauccc aggcuucgca ggagcugaug gaggaccagg gcccaggggc     2160

uugccaggag acgcaggucg ugaaggguuc ccaggacccc caggguucau aggaccccga     2220

ggauccaaag gugcaguggg ccucccuggc ccagauggau ccccaggucc caucggccug     2280

ccagggccag augggccccc uggggaaagg ggccucccug gagaaguccu gggagcucag     2340

cccgggccac ggggagaugc uggugugccu ggacagccug ggcuuaaagg ccuucccgga     2400

gacagaggcc ccccuggauu cagaggaagc caagggaugc cugggaugcc agggcugaag     2460

ggccagccag gccucccagg accuuccggc cagccaggcc uguaugggcc uccaggacug     2520

cauggauucc caggagcucc uggccaagag gggcccuugg ggcugccagg aaucccaggc     2580

cgugaagguc ugccugguga uagaggggac ccuggggaca caggcgcucc uggcccugug     2640

ggcaugaaag gucucucugg ugacagagga gaugcuggcu ucacagggga gcaaggccau     2700

ccaggaagcc cuggauuuaa aggaauugau ggaaugccug ggacccccgg gcuaaaagga     2760

gauagaggcu caccugggau ggaugguuuc caaggcaugc cuggacucaa agggagaccc     2820

ggguuuccag ggagcaaagg cgaggcugga uuuuucggaa uacccggucu gaagggucug     2880

gcuggugagc cagguuuuaa aggcagccga ggggacccug ggcccccagg accaccuccu     2940

gucauccugc caggaaugaa agacauuaaa ggagagaaag gagaugaagg gccuaugggg     3000

cugaaaggau accugggcgc aaaagguauc caaggaaugc caggcauccc agggcuguca     3060

ggaaucccug ggcugccugg gaggcccggc cacaucaaag gagucaaggg agacaucgga     3120

guccccggca uccccgguuu gccaggauuc ccuggggugg cuggcccccc uggaauuacg     3180

ggauucccag gauucauagg aagccggggu gacaaaggug ccccagggag agcaggccug     3240

uauggcgaga uuggcgcgac uggugauuuc ggugacaucg gggacacuau aaauuuacca     3300

ggaagaccag gccugaaggg ggagcggggc accacuggaa uaccaggucu gaagggauuc     3360

uuuggagaga agggaacaga aggugacauc ggcuucccug ggauaacagg cgugacugga     3420

guccaaggcc cuccuggacu uaaaggacaa acaggcuuuc cagggcugac ugggccucca     3480

gggucgcagg gagagcuggg gcggauugga cugccuggug gcaaaggaga ugauggcugg     3540

ccgggagcuc cgggcuuacc agguuuuccg ggacuccgug ggauccgcgg cuuacacggc     3600

uugccaggca ccaagggcuu uccaggaucc ccagguucug acauccacgg agacccaggc     3660

uucccaggcc cuccugggga aagaggugac ccaggagagg ccaacacccu uccaggcccu     3720

gugggagucc caggacagaa aggagaccaa ggagcuccag gggaacgagg cccaccuggg     3780

agcccaggac uucagggguu cccugguauc acacccccuu ccaacaucuc uggggcaccu     3840

ggugacaaag gggcgccagg gauauuuggc cugaaagguu aucggggccc accagggcca     3900

ccagguucug cugcucuucc uggaagcaaa ggugacacag ggaacccagg agcuccagga     3960

accccaggga ccaaaggaug ggccggggac uccgggcccc agggcaggcc ugguguguuu     4020

ggucucccag gagaaaaagg gcccaggggu gaacaaggcu ucauggggaa cacuggaccc     4080

acuggggcgg ugggcgacag aggccccaag ggacccaagg gagacccagg auucccuggu     4140

gcccccggga cugugggagc ccccgggauu gcaggaaucc cccagaagau ugccguccaa     4200

ccagggacag ugggucccca ggggaggcga ggccccccug gggcaccggg ggagaugggg     4260

ccccagggcc cccccggaga accagguuuc cguggggcuc cagggaaagc ugggccccaa     4320

ggaagaggug gugugucugc uguucccggc uuccggggag augaaggacc cauaggccac     4380

caggggccga uuggccaaga aggugcacca ggccguccag ggagcccggg ccugccgggu     4440

augccaggcc gcagcgucag caucggcuac cuccugguga agcacagcca gacggaccag     4500

gagcccaugu gcccaguggg caugaacaaa cucuggagug gauacagccu gcuguacuuc     4560

gagggccagg agaaggcgca caaccaggac cuggggcugg cgggcuccug ccuggcgcgg     4620

uucagcacca ugcccuuccu guacugcaac ccuggugaug ucugcuacua ugccagccgg     4680

aacgacaagu ccuacuggcu cucuaccacu gcgccgcugc ccaugaugcc cguggccgag     4740

gacgagauca agcccuacau cagccgcugu ucugugugug aggccccggc caucgccauc     4800

gcgguccaca gucaggaugu cuccauccca cacugcccag cuggguggcg gaguuugugg     4860

aucggauauu ccuuccucau gcacacggcg gcgggagacg aaggcggugg ccaaucacug     4920

gugucaccgg gcagcugucu agaggacuuc cgcgccacac cauucaucga augcaaugga     4980

ggccgcggca ccugccacua cuacgccaac aaguacagcu ucuggcugac caccauuccc     5040

gagcagagcu uccagggcuc gcccuccgcc gacacgcuca aggccggccu cauccgcaca     5100

cacaucagcc gcugccaggu gugcaugaag aaccuguga                            5139


<210>  7427
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7427
augggccgcg accagcgggc cguggccggg cccgcgcugc gccgguggcu ccugcugggc       60

accgucaccg ugggguuccu cgcccagagc gugcuggccg gcgucaagaa guucgacgug      120

ccgugcgggg gccgcgacug cuccggcggg ugccagugcu accccgagaa gggcgggcgg      180

ggccagcccg ggcccguggg cccgcagggc uacaacgggc cgcccggccu gcagggguuc      240

cccggccucc agggccgcaa gggggacaag ggcgagcgcg gggcccccgg cgucacgggg      300

cccaagggcg acgugggcgc ccggggcgug agcggcuucc ccggggcgga cggcaucccc      360

gggcacccgg gccagggcgg gccccggggc cgccccgggu acgacggcug caacgggacc      420

cagggcgacu ccggccccca ggggccgccc ggcagcgagg gguucaccgg cccgcccggc      480

ccccaggggc ccaagggcca gaagggggag cccuacgccc ugcccaagga ggagcgggac      540

cgcuaccggg gcgagccggg ggagcccggc cuggucggcu uccaggggcc gcccggccgc      600

cccgggcacg ugggccagau ggggcccgug ggcgcccccg gccggccggg gccgcccggc      660

ccgcccgggc ccaagggcca gcaggggaac cgcggccucg gcuucuacgg ggucaagggc      720

gagaaggggg acgugggcca gcccgggccc aacggcaucc ccuccgacac ccugcacccc      780

aucaucgccc ccacgggcgu gaccuuccac cccgaccagu acaaggggga gaagggcagc      840

gagggggagc cgggcauccg gggcaucucc cugaaggggg aggagggcau caugggguuc      900

cccggccucc gcggguaccc cggccugagc ggcgagaagg ggucccccgg ccagaagggg      960

agccggggcc uggacgggua ccagggcccg gacggccccc gcgggcccaa gggcgaggcg     1020

ggggaccccg gcccgcccgg gcuccccgcc uacagccccc acccgucccu ggccaagggc     1080

gcccggggcg accccggguu ccccggcgcc cagggggagc cgggcuccca gggcgagccc     1140

ggggaccccg gccugcccgg gccgcccggc cucagcaucg gggacggcga ccagcgccgc     1200

ggccugcccg gggagauggg ccccaagggg uucaucggcg acccggggau ccccgcgcug     1260

uacggcggcc cgcccgggcc cgacggcaag cgggggccgc ccggcccgcc cgggcucccc     1320

ggcccgcccg gccccgacgg guuccuguuc ggccugaagg gggccaaggg ccgcgccggg     1380

uuccccggcc uccccggcuc ccccggggcc cggggcccca agggguggaa gggcgacgcc     1440

ggcgagugcc gcugcaccga gggggacgag gcgaucaagg gccugcccgg gcugcccggc     1500

cccaaggggu ucgccggcau caacggcgag ccggggcgga agggcgaccg cggggacccc     1560

ggccagcacg ggcuccccgg cuucccgggc cugaaggggg uccccggcaa caucggggcc     1620

cccggcccca agggggccaa gggcgacagc cggaccauca cgaccaaggg cgagcgcggg     1680

cagccgggcg ugcccggggu gcccggcaug aagggggacg acggcucccc cggccgggac     1740

gggcuggacg gcuucccggg gcuccccggc ccgcccggcg acgggaucaa gggcccgccc     1800

ggggaccccg gcuaccccgg gauccccggc accaagggca cccccgggga gaugggcccg     1860

cccgggcugg gccugcccgg gcucaagggc cagcgcggcu uccccgggga cgccggccug     1920

cccgggcccc cgggcuuccu ggggccgccc ggccccgcgg gcacgcccgg gcagaucgac     1980

ugcgacaccg acgucaagcg ggccgugggc ggggaccgcc aggaggccau ccagcccggc     2040

ugcaucggcg ggcccaaggg ccucccgggg cugcccggcc cgcccgggcc caccggcgcc     2100

aagggccugc gggggauccc cggcuucgcc ggggcggacg gcgggcccgg cccccgcggc     2160

cucccggggg acgccggccg ggagggguuc cccggcccgc ccggguucau cggcccccgc     2220

ggcagcaagg gggccguggg ccugcccggg cccgacggcu cccccgggcc gaucggccug     2280

cccggccccg acgggccccc gggcgagcgg gggcuccccg gcgagguccu gggcgcccag     2340

cccgggcccc gcggcgacgc gggggugccg ggccagcccg ggcugaaggg ccuccccggc     2400

gaccgggggc cgcccggcuu ccgcgggagc cagggcaugc ccgggaugcc cggccugaag     2460

ggccagccgg ggcugcccgg ccccagcggg cagcccggcc ucuacgggcc gcccggccug     2520

cacggcuucc ccggggcccc cggccaggag gggccgcugg gccugcccgg cauccccggg     2580

cgcgagggcc uccccgggga ccggggcgac ccgggggaca ccggcgcccc cggccccgug     2640

gggaugaagg gccuguccgg ggaccgcggc gacgccgggu ucacgggcga gcagggccac     2700

cccgggagcc cgggcuucaa ggggaucgac ggcaugcccg ggacccccgg ccugaagggc     2760

gaccgggggu cccccggcau ggacggguuc cagggcaugc cggggcucaa gggccgcccc     2820

ggcuuccccg ggagcaaggg cgaggccggg uucuucggca uccccggccu gaaggggcug     2880

gcgggcgagc cgggguucaa gggcucccgc ggggaccccg ggcccccggg gcccccgccc     2940

gucauccucc ccggcaugaa ggacaucaag ggcgagaagg gggacgaggg ccccaugggg     3000

cugaagggcu accugggcgc caaggggauc cagggcaugc ccgggauccc cggccucagc     3060

gggaucccgg gccugcccgg ccggcccggg cacaucaagg gcgugaaggg ggacaucggc     3120

guccccggca ucccggggcu gcccggcuuc cccggggugg ccgggccccc gggcaucacc     3180

ggcuuccccg gcuucaucgg gucccggggc gacaaggggg cccccggccg cgccgggcuc     3240

uacggcgaga ucggcgcgac cggggacuuc ggcgacaucg gggacacgau caaccugccc     3300

ggccggccgg ggcugaaggg cgagcgcggc accaccggga uccccggccu caagggguuc     3360

uucggcgaga aggggaccga gggcgacauc ggcuuccccg ggaucacggg cgugaccggg     3420

guccaggggc ccccgggccu gaagggccag accggcuucc ccgggcugac cggcccgccc     3480

gggagccagg gcgagcucgg ccggaucggg cugcccggcg ggaagggcga cgacgggugg     3540

cccggcgccc ccggccugcc gggguucccc ggccuccgcg ggauccgggg ccugcacggg     3600

cugcccggca cgaagggcuu ccccgggucc ccgggcagcg acauccacgg ggaccccggc     3660

uuccccgggc ccccgggcga gcgcggcgac cccggggagg ccaacacccu ccccggcccc     3720

gugggggugc cgggccagaa gggcgaccag ggggcccccg gcgagcgggg gccgcccggc     3780

ucccccgggc ugcagggcuu ccccggcauc accccgccca gcaacaucuc cggggccccc     3840

ggcgacaagg gggcgcccgg caucuucggg cugaagggcu accgcggccc gcccgggccg     3900

cccggcagcg ccgcccuccc cggguccaag ggcgacaccg ggaaccccgg cgcccccggc     3960

acgcccggga ccaagggcug ggcgggggac agcggccccc agggccggcc gggggucuuc     4020

ggccugcccg gggagaaggg cccccgcggg gagcagggcu ucaugggcaa caccgggccc     4080

accggcgccg ugggggaccg gggcccgaag gggcccaagg gcgaccccgg cuuccccggg     4140

gccccgggca cggugggggc ccccggcauc gccgggaucc cccagaagau cgcgguccag     4200

cccggcaccg ugggcccgca ggggcgccgg ggcccgcccg gggcccccgg cgagaugggg     4260

ccccagggcc cgcccggcga gcccggguuc cgcggcgccc ccgggaaggc cggcccccag     4320

ggccgcgggg gcguguccgc cguccccggg uuccggggcg acgaggggcc caucggccac     4380

cagggcccga ucgggcagga gggcgcgccc gggcgccccg gcagcccggg gcugcccggc     4440

augcccggcc gguccgugag caucggguac cuccugguga agcacagcca gaccgaccag     4500

gagcccaugu gcccggucgg caugaacaag cugugguccg gguacagccu ccuguacuuc     4560

gagggccagg agaaggccca caaccaggac cuggggcucg ccggcuccug ccuggcccgc     4620

uucagcacca ugcccuuccu guacugcaac cccggcgacg ugugcuacua cgccucccgg     4680

aacgacaaga gcuacuggcu cuccaccacg gcgccccugc cgaugaugcc cguggccgag     4740

gacgagauca agcccuacau cagccgcugc uccgucugcg aggcccccgc caucgcgauc     4800

gccgugcaca gccaggacgu guccaucccg cacugccccg ccggguggcg gagccugugg     4860

aucggcuacu ccuuccucau gcacaccgcc gccggggacg agggcggcgg gcagagccug     4920

gucucccccg gcagcugccu ggaggacuuc cgcgcgaccc ccuucaucga gugcaacggg     4980

ggccggggga ccugccacua cuacgccaac aaguacuccu ucuggcucac gaccaucccg     5040

gagcagagcu uccagggcag ccccuccgcc gacacccuga aggccggccu gauccgcacc     5100

cacaucagcc ggugccaggu gugcaugaag aaccucuga                            5139


<210>  7428
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7428
augggccgcg accagcgcgc cgucgccggc cccgcccucc gccgcuggcu ccuccucggc       60

accgucaccg ucggcuuccu cgcccagucc guccucgccg gcgucaagaa guucgacguc      120

cccugcggcg gccgcgacug cuccggcggc ugccagugcu accccgagaa gggcggccgc      180

ggccagcccg gccccgucgg cccccagggc uacaacggcc cccccggccu ccagggcuuc      240

cccggccucc agggccgcaa gggcgacaag ggcgagcgcg gcgcccccgg cgucaccggc      300

cccaagggcg acgucggcgc ccgcggcguc uccggcuucc ccggcgccga cggcaucccc      360

ggccaccccg gccagggcgg cccccgcggc cgccccggcu acgacggcug caacggcacc      420

cagggcgacu ccggccccca gggccccccc ggcuccgagg gcuucaccgg cccccccggc      480

ccccagggcc ccaagggcca gaagggcgag cccuacgccc uccccaagga ggagcgcgac      540

cgcuaccgcg gcgagcccgg cgagcccggc cucgucggcu uccagggccc ccccggccgc      600

cccggccacg ucggccagau gggccccguc ggcgcccccg gccgccccgg cccccccggc      660

ccccccggcc ccaagggcca gcagggcaac cgcggccucg gcuucuacgg cgucaagggc      720

gagaagggcg acgucggcca gcccggcccc aacggcaucc ccuccgacac ccuccacccc      780

aucaucgccc ccaccggcgu caccuuccac cccgaccagu acaagggcga gaagggcucc      840

gagggcgagc ccggcauccg cggcaucucc cucaagggcg aggagggcau caugggcuuc      900

cccggccucc gcggcuaccc cggccucucc ggcgagaagg gcucccccgg ccagaagggc      960

ucccgcggcc ucgacggcua ccagggcccc gacggccccc gcggccccaa gggcgaggcc     1020

ggcgaccccg gcccccccgg ccuccccgcc uacucccccc accccucccu cgccaagggc     1080

gcccgcggcg accccggcuu ccccggcgcc cagggcgagc ccggcuccca gggcgagccc     1140

ggcgaccccg gccuccccgg cccccccggc cucuccaucg gcgacggcga ccagcgccgc     1200

ggccuccccg gcgagauggg ccccaagggc uucaucggcg accccggcau ccccgcccuc     1260

uacggcggcc cccccggccc cgacggcaag cgcggccccc ccggcccccc cggccucccc     1320

ggcccccccg gccccgacgg cuuccucuuc ggccucaagg gcgccaaggg ccgcgccggc     1380

uuccccggcc uccccggcuc ccccggcgcc cgcggcccca agggcuggaa gggcgacgcc     1440

ggcgagugcc gcugcaccga gggcgacgag gccaucaagg gccuccccgg ccuccccggc     1500

cccaagggcu ucgccggcau caacggcgag cccggccgca agggcgaccg cggcgacccc     1560

ggccagcacg gccuccccgg cuuccccggc cucaagggcg uccccggcaa caucggcgcc     1620

cccggcccca agggcgccaa gggcgacucc cgcaccauca ccaccaaggg cgagcgcggc     1680

cagcccggcg uccccggcgu ccccggcaug aagggcgacg acggcucccc cggccgcgac     1740

ggccucgacg gcuuccccgg ccuccccggc ccccccggcg acggcaucaa gggccccccc     1800

ggcgaccccg gcuaccccgg cauccccggc accaagggca cccccggcga gaugggcccc     1860

cccggccucg gccuccccgg ccucaagggc cagcgcggcu uccccggcga cgccggccuc     1920

cccggccccc ccggcuuccu cggccccccc ggccccgccg gcacccccgg ccagaucgac     1980

ugcgacaccg acgucaagcg cgccgucggc ggcgaccgcc aggaggccau ccagcccggc     2040

ugcaucggcg gccccaaggg ccuccccggc cuccccggcc cccccggccc caccggcgcc     2100

aagggccucc gcggcauccc cggcuucgcc ggcgccgacg gcggccccgg cccccgcggc     2160

cuccccggcg acgccggccg cgagggcuuc cccggccccc ccggcuucau cggcccccgc     2220

ggcuccaagg gcgccgucgg ccuccccggc cccgacggcu cccccggccc caucggccuc     2280

cccggccccg acggcccccc cggcgagcgc ggccuccccg gcgagguccu cggcgcccag     2340

cccggccccc gcggcgacgc cggcgucccc ggccagcccg gccucaaggg ccuccccggc     2400

gaccgcggcc cccccggcuu ccgcggcucc cagggcaugc ccggcaugcc cggccucaag     2460

ggccagcccg gccuccccgg ccccuccggc cagcccggcc ucuacggccc ccccggccuc     2520

cacggcuucc ccggcgcccc cggccaggag ggcccccucg gccuccccgg cauccccggc     2580

cgcgagggcc uccccggcga ccgcggcgac cccggcgaca ccggcgcccc cggccccguc     2640

ggcaugaagg gccucuccgg cgaccgcggc gacgccggcu ucaccggcga gcagggccac     2700

cccggcuccc ccggcuucaa gggcaucgac ggcaugcccg gcacccccgg ccucaagggc     2760

gaccgcggcu cccccggcau ggacggcuuc cagggcaugc ccggccucaa gggccgcccc     2820

ggcuuccccg gcuccaaggg cgaggccggc uucuucggca uccccggccu caagggccuc     2880

gccggcgagc ccggcuucaa gggcucccgc ggcgaccccg gcccccccgg cccccccccc     2940

gucauccucc ccggcaugaa ggacaucaag ggcgagaagg gcgacgaggg ccccaugggc     3000

cucaagggcu accucggcgc caagggcauc cagggcaugc ccggcauccc cggccucucc     3060

ggcauccccg gccuccccgg ccgccccggc cacaucaagg gcgucaaggg cgacaucggc     3120

guccccggca uccccggccu ccccggcuuc cccggcgucg ccggcccccc cggcaucacc     3180

ggcuuccccg gcuucaucgg cucccgcggc gacaagggcg cccccggccg cgccggccuc     3240

uacggcgaga ucggcgccac cggcgacuuc ggcgacaucg gcgacaccau caaccucccc     3300

ggccgccccg gccucaaggg cgagcgcggc accaccggca uccccggccu caagggcuuc     3360

uucggcgaga agggcaccga gggcgacauc ggcuuccccg gcaucaccgg cgucaccggc     3420

guccagggcc cccccggccu caagggccag accggcuucc ccggccucac cggccccccc     3480

ggcucccagg gcgagcucgg ccgcaucggc cuccccggcg gcaagggcga cgacggcugg     3540

cccggcgccc ccggccuccc cggcuucccc ggccuccgcg gcauccgcgg ccuccacggc     3600

cuccccggca ccaagggcuu ccccggcucc cccggcuccg acauccacgg cgaccccggc     3660

uuccccggcc cccccggcga gcgcggcgac cccggcgagg ccaacacccu ccccggcccc     3720

gucggcgucc ccggccagaa gggcgaccag ggcgcccccg gcgagcgcgg cccccccggc     3780

ucccccggcc uccagggcuu ccccggcauc accccccccu ccaacaucuc cggcgccccc     3840

ggcgacaagg gcgcccccgg caucuucggc cucaagggcu accgcggccc ccccggcccc     3900

cccggcuccg ccgcccuccc cggcuccaag ggcgacaccg gcaaccccgg cgcccccggc     3960

acccccggca ccaagggcug ggccggcgac uccggccccc agggccgccc cggcgucuuc     4020

ggccuccccg gcgagaaggg cccccgcggc gagcagggcu ucaugggcaa caccggcccc     4080

accggcgccg ucggcgaccg cggccccaag ggccccaagg gcgaccccgg cuuccccggc     4140

gcccccggca ccgucggcgc ccccggcauc gccggcaucc cccagaagau cgccguccag     4200

cccggcaccg ucggccccca gggccgccgc ggcccccccg gcgcccccgg cgagaugggc     4260

ccccagggcc cccccggcga gcccggcuuc cgcggcgccc ccggcaaggc cggcccccag     4320

ggccgcggcg gcgucuccgc cguccccggc uuccgcggcg acgagggccc caucggccac     4380

cagggcccca ucggccagga gggcgccccc ggccgccccg gcucccccgg ccuccccggc     4440

augcccggcc gcuccgucuc caucggcuac cuccucguca agcacuccca gaccgaccag     4500

gagcccaugu gccccgucgg caugaacaag cucugguccg gcuacucccu ccucuacuuc     4560

gagggccagg agaaggccca caaccaggac cucggccucg ccggcuccug ccucgcccgc     4620

uucuccacca ugcccuuccu cuacugcaac cccggcgacg ucugcuacua cgccucccgc     4680

aacgacaagu ccuacuggcu cuccaccacc gccccccucc ccaugaugcc cgucgccgag     4740

gacgagauca agcccuacau cucccgcugc uccgucugcg aggcccccgc caucgccauc     4800

gccguccacu cccaggacgu cuccaucccc cacugccccg ccggcuggcg cucccucugg     4860

aucggcuacu ccuuccucau gcacaccgcc gccggcgacg agggcggcgg ccagucccuc     4920

gucucccccg gcuccugccu cgaggacuuc cgcgccaccc ccuucaucga gugcaacggc     4980

ggccgcggca ccugccacua cuacgccaac aaguacuccu ucuggcucac caccaucccc     5040

gagcaguccu uccagggcuc ccccuccgcc gacacccuca aggccggccu cauccgcacc     5100

cacaucuccc gcugccaggu cugcaugaag aaccucuga                            5139


<210>  7429
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7429
augggcagag accagagggc cguggcuggg cccgcacugc ggcgcuggcu ccuucuggga       60

accgucacag uugguuucuu ggcccaaagc guguuagcgg gcguaaagaa auuugaugug      120

ccuugcgggg gacgagacug uuccggcggu ugccaguguu acccagagaa gggaggacgu      180

ggccagccgg gccccgucgg gccucaggga uauaacgguc cacccggccu gcaaggguuc      240

ccuggacuac agggcagaaa aggugauaag ggggaaaggg gagcuccagg cgugacuggc      300

cccaaagggg acguuggagc ccggggugug ucuggcuuuc cuggggcaga uggaauccca      360

ggccacccgg gucagggcgg cccccgcgga agaccuggcu acgacgggug caauggaacg      420

cagggugauu caggcccaca agggcccccu ggaagugagg gcuucaccgg uccacccggg      480

ccgcagggcc cuaagggaca gaagggcgaa cccuaugccc ucccaaaaga ggaaagggac      540

cgguaccgcg gggagccugg agagcccggu cuggucggcu uucaggggcc acccggacga      600

ccuggccaug ugggucaaau ggggccagua ggcgcuccgg gaagacccgg cccuccaggg      660

cccccuggac caaagggcca gcaggguaac agggggcuug gauucuaugg cguuaaaggu      720

gaaaagggcg auguggggca acccggaccg aauggcauuc cuagcgacac acugcaccca      780

auaaucgcac ccacuggggu caccuuucau ccugaucagu acaaaggaga gaagggcucc      840

gaaggugagc ccgggauucg gggaaucucu uugaagggcg aggaagguau uaugggcuuc      900

ccagggcucc guggauaucc uggccugucg ggggagaaag gaucacccgg ccagaagggu      960

agccgcgggc uggacggaua ccagggccca gaugguccga gaggcccuaa aggggaagcc     1020

ggagaccccg gcccacccgg gcucccugcu uacaguccac accccuccuu agccaaggga     1080

gcgaggggcg acccugguuu uccgggggca caaggagagc caggcucuca gggcgaaccc     1140

ggggauccug gacugccagg ucccccuggc cuuagcaucg gggacggaga ucagcggcga     1200

ggcuugccgg gugagauggg gcccaaagga uucauaggcg acccaggcau cccugcccug     1260

uaugggggac ccccaggucc ugauggcaag cgcgggcccc caggaccgcc uggccuaccc     1320

gguccacccg ggccugacgg auuucucuuc ggccugaaag gcgcuaaggg gagagccgga     1380

uuuccagguc uucccggcuc cccuggggca aggggaccga agggcuggaa aggugaugcu     1440

ggggaguguc ggugcacaga aggagacgag gccauuaagg gccugccagg cuugcccggg     1500

ccuaaaggau ucgcggguau caacggcgaa cccgggcgca agggagauag aggcgaccca     1560

ggucagcaug ggcucccugg auuccccggc cugaaaggcg ugccagggaa uauuggagcc     1620

ccugguccga agggcgcaaa gggggauuca aggaccauca cuacaaaagg agagcguggc     1680

caacccggug ugccaggggu cccuggcaug aagggagacg acggcagucc cgggcgggau     1740

ggauuagacg guuuuccagg ccugccuggg cccccgggag auggcauaaa agguccaccu     1800

ggggaccccg gcuacccagg gauucccggc accaagggga cgccuggaga aauggguccg     1860

cccggccucg ggcuuccagg acugaaaggc cagcgagguu ucccugggga ugcuggcuug     1920

cccggaccuc caggcuuucu agggcccccu ggaccagccg gcacucccgg ucagaucgac     1980

ugugauaccg acguuaagag agcuguaggg ggagauaggc aggaggccau ucaaccgggc     2040

ugcaucggug gcccuaaggg gcugccagga cuccccggcc cuccagggcc cacaggagca     2100

aaaggccugc gcgguauccc gggguucgcc ggagcugacg gcgguccugg cccccggggg     2160

cuuccaggag augcgggcag agagggguuu ccuggacccc caggcuucau uggucccagg     2220

gggagcaagg gagcaguggg ccugccuggc ccagacgggu cuccgggacc cauagguuug     2280

ccuggcccag augggccccc uggagaacgc ggccucccag gugaggugcu gggggcccag     2340

cccggaccuc gaggcgacgc uggcgucccg gggcagccag gauuaaaagg ucugcccggc     2400

gaccgggggc cucccggauu ucguggcucc caggguaugc cagggaugcc uggacuaaag     2460

ggccaacccg gccucccagg gccgucagga cagccugguc uguaugggcc cccagggcuu     2520

cacggauucc ccggcgcccc uggucaggaa gggccauugg gacugcccgg caucccuggc     2580

agagaggggc ucccgggaga uaggggugac ccaggcgaua cuggggcacc cggaccugug     2640

ggcaugaaag gucugagcgg ggaccgcgga gaugccggcu uuaccggcga acaagggcac     2700

ccaggaaguc ccgguuucaa gggcauugac gggaugccug gaacacccgg ccuuaagggu     2760

gaucgggggu cuccaggaau ggacggcuuu cagggcaugc cggggcugaa aggaagaccu     2820

gguuuccccg gcuccaaggg ggaggcugga uuuuucggca ucccagguuu gaaagggcuc     2880

gccggcgagc cuggauucaa gggcagccga ggggaucccg gaccaccugg ucccccgcca     2940

guuauacugc cuggcaugaa agacauuaag ggggaaaaag gagaugaggg ccccaugggu     3000

uuaaaggggu accugggcgc aaagggaauc cagggcaugc cagggauccc cggacuaucg     3060

gguauuccug gccucccggg gaggccagga cauaucaaag gcgugaaggg ugacauuggc     3120

guccccggga uaccuggacu gcccggcuuu ccaggggugg cgggaccucc cggcaucacc     3180

gguuucccag gguuuauugg aucucgcggc gauaaaggug cuccuggccg ggccgggcuu     3240

uauggagaaa ucggcgcaac gggggacuuc ggagacaucg gcgauacuau uaacuugccg     3300

gguagacccg ggcugaaggg agagaggggc acaaccggua uaccaggccu caaaggguuu     3360

uucggagaga agggcacuga aggggacauc ggauuuccug gcauuacagg uguaaccggg     3420

guucagggac ccccaggccu gaagggccaa acgggguucc cuggauuaac cggucccccg     3480

ggcucccagg gggagcuggg acguaucggc cuuccaggug ggaaaggaga ugacggcugg     3540

ccuggcgccc ccggguugcc aggauuuccc ggucuccgcg gcauucgggg gcugcacgga     3600

cuaccuggca caaaggguuu ccccggguca ccaggaagug auauccaugg cgacccuggc     3660

uuuccggggc ccccaggaga aagaggugau ccuggcgagg cuaauacucu gcccgggcca     3720

gugggagucc cuggccagaa aggugaccag ggggcccccg gagaaagggg cccgccuggc     3780

agcccagggc uccaaggauu ccccgguaua accccuccau ccaacaucuc uggcgcaccc     3840

ggggauaagg gagcuccugg cauuuuuggu cugaaagggu accgaggacc acccggcccg     3900

ccuggcagcg ccgcgcuucc cgggucaaag ggagacacag guaauccagg cgcccccggg     3960

acuccuggaa ccaagggcug ggcuggugau agugggccac agggccggcc cggaguguuc     4020

ggcuugccug gggagaaagg accacgcggu gagcagggcu ucauggggaa cacaggaccg     4080

accggcgcag ucggugacag agggcccaag ggcccuaaag gagacccagg cuuucccggg     4140

gccccuggaa cugugggugc uccaggcauc gccgggauuc cccagaagau cgcaguucaa     4200

ccgggaacgg ugggcccuca ggguaggcgg gggccacccg gcgcgccugg agaaaugggc     4260

ccccaggggc caccgggaga gccugguuuc cgaggcgccc ccgggaaagc uggaccacaa     4320

ggcagaggug gcguauccgc cguccccggg uuucgcggag augaaggccc uauagggcac     4380

cagggaccaa uuggccagga gggugcaccc gggaggccug gaagcccagg ccugccgggu     4440

augcccggcc guucuguguc aaucggguau uuacucguua agcacaguca gacagaccaa     4500

gaaccuaugu guccaguggg aaugaauaag cuguggagcg gcuacucccu ucuguacuuc     4560

gaggggcagg agaaagcuca uaaccaggau uugggacucg ccggcucuug ccuggcacgg     4620

uuuucgacca ugcccuuccu auauuguaau ccuggugacg ucugcuacua ugccagcaga     4680

aacgauaagu ccuacuggcu gucaacuacc gcuccacucc ccaugaugcc uguggcggaa     4740

gacgagauua aaccguauau caguaggugc ucuguaugug aagcccccgc aauagcuauc     4800

gccgugcaca gccaggaugu uuccauucca cauugcccug ccggguggcg cucacugugg     4860

aucggauaca gcuuucuuau gcacacagcu gcaggcgacg aggguggcgg gcaaucuuug     4920

gucucccccg gaaguugucu ggaagauuuc cgagccaccc cauuuauuga gugcaauggc     4980

gggagaggaa cuugucauua uuacgcgaac aaguacagcu ucugguuaac aacgaucccu     5040

gagcagucuu uucagggcuc ccccucagcu gacacccuca aagccggucu gauacggacu     5100

cacauuagua ggugccaggu guguaugaag aaccuuuga                            5139


<210>  7430
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7430
augggcagag accagagagc cguggccggc cccgcccuga gaagauggcu gcugcugggc       60

accgugaccg ugggcuuccu ggcccagagc gugcuggccg gcgugaagaa guucgacgug      120

cccugcggcg gcagagacug cagcggcggc ugccagugcu accccgagaa gggcggcaga      180

ggccagcccg gccccguggg cccccagggc uacaacggcc cccccggccu gcagggcuuc      240

cccggccugc agggcagaaa gggcgacaag ggcgagagag gcgcccccgg cgugaccggc      300

cccaagggcg acgugggcgc cagaggcgug agcggcuucc ccggcgccga cggcaucccc      360

ggccaccccg gccagggcgg ccccagaggc agacccggcu acgacggcug caacggcacc      420

cagggcgaca gcggccccca gggccccccc ggcagcgagg gcuucaccgg cccccccggc      480

ccccagggcc ccaagggcca gaagggcgag cccuacgccc ugcccaagga ggagagagac      540

agauacagag gcgagcccgg cgagcccggc cuggugggcu uccagggccc ccccggcaga      600

cccggccacg ugggccagau gggccccgug ggcgcccccg gcagacccgg cccccccggc      660

ccccccggcc ccaagggcca gcagggcaac agaggccugg gcuucuacgg cgugaagggc      720

gagaagggcg acgugggcca gcccggcccc aacggcaucc ccagcgacac ccugcacccc      780

aucaucgccc ccaccggcgu gaccuuccac cccgaccagu acaagggcga gaagggcagc      840

gagggcgagc ccggcaucag aggcaucagc cugaagggcg aggagggcau caugggcuuc      900

cccggccuga gaggcuaccc cggccugagc ggcgagaagg gcagccccgg ccagaagggc      960

agcagaggcc uggacggcua ccagggcccc gacggcccca gaggccccaa gggcgaggcc     1020

ggcgaccccg gcccccccgg ccugcccgcc uacagccccc accccagccu ggccaagggc     1080

gccagaggcg accccggcuu ccccggcgcc cagggcgagc ccggcagcca gggcgagccc     1140

ggcgaccccg gccugcccgg cccccccggc cugagcaucg gcgacggcga ccagagaaga     1200

ggccugcccg gcgagauggg ccccaagggc uucaucggcg accccggcau ccccgcccug     1260

uacggcggcc cccccggccc cgacggcaag agaggccccc ccggcccccc cggccugccc     1320

ggcccccccg gccccgacgg cuuccuguuc ggccugaagg gcgccaaggg cagagccggc     1380

uuccccggcc ugcccggcag ccccggcgcc agaggcccca agggcuggaa gggcgacgcc     1440

ggcgagugca gaugcaccga gggcgacgag gccaucaagg gccugcccgg ccugcccggc     1500

cccaagggcu ucgccggcau caacggcgag cccggcagaa agggcgacag aggcgacccc     1560

ggccagcacg gccugcccgg cuuccccggc cugaagggcg ugcccggcaa caucggcgcc     1620

cccggcccca agggcgccaa gggcgacagc agaaccauca ccaccaaggg cgagagaggc     1680

cagcccggcg ugcccggcgu gcccggcaug aagggcgacg acggcagccc cggcagagac     1740

ggccuggacg gcuuccccgg ccugcccggc ccccccggcg acggcaucaa gggccccccc     1800

ggcgaccccg gcuaccccgg cauccccggc accaagggca cccccggcga gaugggcccc     1860

cccggccugg gccugcccgg ccugaagggc cagagaggcu uccccggcga cgccggccug     1920

cccggccccc ccggcuuccu gggccccccc ggccccgccg gcacccccgg ccagaucgac     1980

ugcgacaccg acgugaagag agccgugggc ggcgacagac aggaggccau ccagcccggc     2040

ugcaucggcg gccccaaggg ccugcccggc cugcccggcc cccccggccc caccggcgcc     2100

aagggccuga gaggcauccc cggcuucgcc ggcgccgacg gcggccccgg ccccagaggc     2160

cugcccggcg acgccggcag agagggcuuc cccggccccc ccggcuucau cggccccaga     2220

ggcagcaagg gcgccguggg ccugcccggc cccgacggca gccccggccc caucggccug     2280

cccggccccg acggcccccc cggcgagaga ggccugcccg gcgaggugcu gggcgcccag     2340

cccggcccca gaggcgacgc cggcgugccc ggccagcccg gccugaaggg ccugcccggc     2400

gacagaggcc cccccggcuu cagaggcagc cagggcaugc ccggcaugcc cggccugaag     2460

ggccagcccg gccugcccgg ccccagcggc cagcccggcc uguacggccc ccccggccug     2520

cacggcuucc ccggcgcccc cggccaggag ggcccccugg gccugcccgg cauccccggc     2580

agagagggcc ugcccggcga cagaggcgac cccggcgaca ccggcgcccc cggccccgug     2640

ggcaugaagg gccugagcgg cgacagaggc gacgccggcu ucaccggcga gcagggccac     2700

cccggcagcc ccggcuucaa gggcaucgac ggcaugcccg gcacccccgg ccugaagggc     2760

gacagaggca gccccggcau ggacggcuuc cagggcaugc ccggccugaa gggcagaccc     2820

ggcuuccccg gcagcaaggg cgaggccggc uucuucggca uccccggccu gaagggccug     2880

gccggcgagc ccggcuucaa gggcagcaga ggcgaccccg gcccccccgg cccccccccc     2940

gugauccugc ccggcaugaa ggacaucaag ggcgagaagg gcgacgaggg ccccaugggc     3000

cugaagggcu accugggcgc caagggcauc cagggcaugc ccggcauccc cggccugagc     3060

ggcauccccg gccugcccgg cagacccggc cacaucaagg gcgugaaggg cgacaucggc     3120

gugcccggca uccccggccu gcccggcuuc cccggcgugg ccggcccccc cggcaucacc     3180

ggcuuccccg gcuucaucgg cagcagaggc gacaagggcg cccccggcag agccggccug     3240

uacggcgaga ucggcgccac cggcgacuuc ggcgacaucg gcgacaccau caaccugccc     3300

ggcagacccg gccugaaggg cgagagaggc accaccggca uccccggccu gaagggcuuc     3360

uucggcgaga agggcaccga gggcgacauc ggcuuccccg gcaucaccgg cgugaccggc     3420

gugcagggcc cccccggccu gaagggccag accggcuucc ccggccugac cggccccccc     3480

ggcagccagg gcgagcuggg cagaaucggc cugcccggcg gcaagggcga cgacggcugg     3540

cccggcgccc ccggccugcc cggcuucccc ggccugagag gcaucagagg ccugcacggc     3600

cugcccggca ccaagggcuu ccccggcagc cccggcagcg acauccacgg cgaccccggc     3660

uuccccggcc cccccggcga gagaggcgac cccggcgagg ccaacacccu gcccggcccc     3720

gugggcgugc ccggccagaa gggcgaccag ggcgcccccg gcgagagagg cccccccggc     3780

agccccggcc ugcagggcuu ccccggcauc acccccccca gcaacaucag cggcgccccc     3840

ggcgacaagg gcgcccccgg caucuucggc cugaagggcu acagaggccc ccccggcccc     3900

cccggcagcg ccgcccugcc cggcagcaag ggcgacaccg gcaaccccgg cgcccccggc     3960

acccccggca ccaagggcug ggccggcgac agcggccccc agggcagacc cggcguguuc     4020

ggccugcccg gcgagaaggg ccccagaggc gagcagggcu ucaugggcaa caccggcccc     4080

accggcgccg ugggcgacag aggccccaag ggccccaagg gcgaccccgg cuuccccggc     4140

gcccccggca ccgugggcgc ccccggcauc gccggcaucc cccagaagau cgccgugcag     4200

cccggcaccg ugggccccca gggcagaaga ggcccccccg gcgcccccgg cgagaugggc     4260

ccccagggcc cccccggcga gcccggcuuc agaggcgccc ccggcaaggc cggcccccag     4320

ggcagaggcg gcgugagcgc cgugcccggc uucagaggcg acgagggccc caucggccac     4380

cagggcccca ucggccagga gggcgccccc ggcagacccg gcagccccgg ccugcccggc     4440

augcccggca gaagcgugag caucggcuac cugcugguga agcacagcca gaccgaccag     4500

gagcccaugu gccccguggg caugaacaag cuguggagcg gcuacagccu gcuguacuuc     4560

gagggccagg agaaggccca caaccaggac cugggccugg ccggcagcug ccuggccaga     4620

uucagcacca ugcccuuccu guacugcaac cccggcgacg ugugcuacua cgccagcaga     4680

aacgacaaga gcuacuggcu gagcaccacc gccccccugc ccaugaugcc cguggccgag     4740

gacgagauca agcccuacau cagcagaugc agcgugugcg aggcccccgc caucgccauc     4800

gccgugcaca gccaggacgu gagcaucccc cacugccccg ccggcuggag aagccugugg     4860

aucggcuaca gcuuccugau gcacaccgcc gccggcgacg agggcggcgg ccagagccug     4920

gugagccccg gcagcugccu ggaggacuuc agagccaccc ccuucaucga gugcaacggc     4980

ggcagaggca ccugccacua cuacgccaac aaguacagcu ucuggcugac caccaucccc     5040

gagcagagcu uccagggcag ccccagcgcc gacacccuga aggccggccu gaucagaacc     5100

cacaucagca gaugccaggu gugcaugaag aaccuguga                            5139


<210>  7431
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7431
augggcagag accagcgggc cguggcuggg cccgcccugc gcagauggcu ccugcuugga       60

accgucacag uuggcuuccu ggcgcaaagc gugcucgcug gggugaagaa auuugauguc      120

ccuugcggag gccgggacug uuccggggga ugccaguguu acccggagaa gggcggccgc      180

gggcagcccg gaccuguggg cccccagggg uauaacggac cucccggccu gcaaggguuc      240

ccuggacuuc agggcagaaa aggcgauaag ggggaacggg gagccccggg cguuacgggg      300

cccaaaggag acgugggcgc ccgcgggguc ucuggauuuc cuggcgcuga uggcaucccc      360

gggcacccug gacagggcgg gcccagagga cggccgggcu acgacgggug caauggcacc      420

cagggagaua gcggcccuca agggcccccu ggauccgagg gcuucacagg gccucccgga      480

ccccagggcc cgaaggggca gaagggcgaa cccuaugccc ugccuaaaga ggaacgcgac      540

agauaccggg gagagcccgg cgagccuggg cucgugggau uucagggacc cccggggcgc      600

ccuggacaug uuggccaaau ggggcccgug ggcgcuccug gaagacccgg cccucccggg      660

ccgccuggac ccaagggcca gcaggggaac cggggacugg gcuucuaugg ggucaaaggc      720

gaaaagggag augugggcca acccgggccu aauggcauuc cgucugacac ccugcacccc      780

aucauugccc cuacaggcgu gaccuuucau cccgaucagu acaaagggga gaagggaagc      840

gaaggcgagc cuggcauccg cgggauuucc cucaagggag aggaaggcau caugggguuc      900

cccggacuga gaggcuaucc ugggcuuucu ggagagaaag gcagccccgg ccagaagggg      960

ucccggggac uggacggcua ccaggggccg gauggaccua gaggccccaa aggggaagcg     1020

ggagacccug ggcccccggg ccucccugcc uacagccccc acccuucucu ggcuaagggc     1080

gcccgcggag accccggcuu ucccggggcu caaggagagc cuggcuccca gggggaaccg     1140

ggagaucccg gccuuccugg gcccccuggc cugagcaucg gagacggcga ucagcggaga     1200

gggcuccccg gagagauggg cccuaaaggg uucauuggag acccgggcau ccccgcccug     1260

uauggcgggc cucccggacc ugauggcaag cgcgggcccc cgggaccucc cggccugccc     1320

gggccucccg gaccugacgg cuuucucuuc ggccugaaag gggcgaaggg acgggccggc     1380

uuuccggggc uucccggauc uccuggcgcu agagggccca agggauggaa aggcgaugcc     1440

ggcgaguguc gcugcacaga aggggacgag gcuauuaagg gacugccugg ccuccccggg     1500

ccgaaaggau ucgccggcau caacggggaa ccuggccgga agggagauag aggcgacccc     1560

gggcagcaug gacugccugg cuuccccggg cuuaaaggag ucccuggcaa uauuggggcc     1620

cccggcccga agggagcuaa gggcgauucc cgcaccauca cgaccaaagg ggagcgggga     1680

caaccuggcg uucccggggu gcccggaaug aagggcgacg acgggagccc uggcagagau     1740

ggacuggacg gcuuuccggg gcuccccgga ccucccggcg augggauuaa aggaccuccc     1800

ggcgacccug gcuacccggg gauccccgga acaaagggca ccccugggga aaugggaccc     1860

ccuggccugg ggcugcccgg acucaaaggc cagcgcggcu ucccggggga ugcgggacug     1920

ccuggcccuc ccggguuucu uggaccuccc ggccccgccg ggacaccggg acagaucgac     1980

ugugauaccg acgugaagcg ggcugucggc ggcgauagac aggaggccau ucaacccggg     2040

ugcaucggag gcccuaaggg gcugcccgga cucccugggc ccccgggccc uacgggagcc     2100

aaaggccugc ggggcauucc cggguucgcu ggagccgacg gcgggccugg accccgcggc     2160

cuuccugggg augcgggaag agagggcuuu cccggcccgc cuggguucau cggaccccgg     2220

ggcucuaagg gggcuguggg acugcccggc ccugacgggu ccccgggacc cauuggccuc     2280

ccuggccccg augggccucc cggagaaaga ggccugccug gggagguucu gggagcccag     2340

cccggcccgc gcggggacgc cggagugccu ggccagcccg gccucaaagg gcugccugga     2400

gaccgggggc ccccgggcuu uagaggaagc cagggcaugc cugggaugcc cggccuuaag     2460

ggacaacccg gccugccugg gcccuccgga cagccuggcc ucuaugggcc gcccggacug     2520

cacggcuucc cuggggcucc cggccaggaa ggaccucugg gccuucccgg gaucccugga     2580

cgcgagggcc ucccggggga uagaggagac cccggcgaua caggggcccc uggccccguc     2640

ggaaugaaag gccugucugg ggaccgggga gaugcuggcu uuaccgggga acaaggacac     2700

ccuggcagcc ccggguucaa gggcaucgac ggaaugccgg gcacaccugg gcugaaggga     2760

gaucgcggcu cccccgggau ggacggauuu cagggcaugc ccggccucaa agggagaccu     2820

ggauuccccg gcagcaaggg ggaggccgga uuuuucggca uuccugggcu gaaaggacuu     2880

gcgggcgagc cgggcuucaa ggggucucgg ggagaucccg gcccucccgg gccucccccg     2940

gugauccugc cuggaaugaa agacauuaag ggcgaaaaag gggaugaggg acccaugggc     3000

cucaagggcu accugggggc caagggaauc cagggcaugc cugggauucc cggacugucc     3060

ggcaucccgg ggcuuccugg acgccccggc cauaucaaag gcguuaaggg ggacauugga     3120

gugcccggca ucccugggcu ccccggauuu ccuggcgucg cugggccgcc cggaauuacc     3180

ggcuucccug gcuuuaucgg gagcagagga gauaaaggcg cccccgggcg ggcuggacug     3240

uauggcgaaa uuggggccac cggagacuuc ggcgacaucg gcgauacaau uaaccugccu     3300

gggcgccccg gacucaaggg cgagagaggg acgaccggaa ucccuggccu gaaaggguuu     3360

uucggagaga agggcacaga aggcgacauc ggguuuccgg gaauuaccgg cgugacaggg     3420

guccagggac ccccuggccu uaaggggcaa accggcuucc ccggacugac gggcccuccc     3480

gggucucagg gagagcucgg ccggaucggg cugccgggag gcaaagggga ugacggcugg     3540

ccuggagcgc ccggccugcc cggguuuccu ggacuucgcg gcauuagagg gcuccacgga     3600

cugcccggca caaagggguu cccuggcagc ccgggauccg auauccaugg cgaccccggg     3660

uuuccuggac ccccuggcga aagaggggau cccggagagg ccaauacccu gccgggcccu     3720

guggggguuc ccggccagaa aggagaccag ggcgcuccug gggaacgggg acccccuggc     3780

ucucccgggc uccaaggauu cccgggcauu acacccccua gcaacaucuc cggcgccccc     3840

ggggauaagg gagcuccugg caucuuuggg cugaaaggau accgcggccc gcccgggccu     3900

cccggaagcg ccgcccuucc uggcucuaag ggcgacaccg ggaaucccgg agcuccuggc     3960

acccccggga caaagggaug ggcgggcgau uccgggccgc agggacggcc uggcguguuc     4020

ggccugcccg gggagaaagg accuagaggc gagcaggggu ucaugggaaa cacgggcccc     4080

accggggccg ucggagaccg cggcccgaag ggcccuaaag gggaccccgg auuucccggc     4140

gcuccuggga cagugggagc ccccggcauu gccgggaucc cucagaagau ugcuguucaa     4200

ccgggaaccg ugggccccca gggccggaga gggccucccg gagccccugg cgaaaugggg     4260

ccccagggac cgccuggcga gcccggguuc cgcggagcgc cuggcaaagc uggcccccaa     4320

gggcggggag gcgucagcgc cgugccuggg uuuagaggag augaaggccc caucgggcac     4380

cagggaccga uuggccagga gggcgccccc gggcgcccug gaucucccgg ccucccuggg     4440

augcccggac gguccgugag caucggcuau cugcugguua agcacuccca gacagaccaa     4500

gaaccuaugu guccggucgg gaugaauaaa cuuuggucug gcuacagccu ccuguacuuc     4560

gagggacagg agaaggcuca uaaccaggau cugggccucg ccggguccug ccuggcgaga     4620

uuuucuacca ugcccuuccu uuauuguaau ccuggagacg ugugcuacua ugcuagccgg     4680

aacgauaagu ccuacuggcu gagcacgacc gcuccccucc cuaugaugcc cguggccgaa     4740

gacgagauca aaccguauau uucucgcugc uccgucugug aagccccugc caucgcuauu     4800

gccgugcaca gccaggaugu uucuaucccc cauugcccug cgggcuggag aucccugugg     4860

auuggguaca gcuuucugau gcacacagcc gcuggagacg agggcggggg ccaaucucuu     4920

gugagccccg gauccugucu ggaagauuuc cgggccaccc cguuuaucga gugcaauggc     4980

gggcgcggaa caugucauua uuacgcuaac aaguacagcu ucuggcucac cacgaucccu     5040

gagcagucuu uucagggcuc ccccagcgcc gacacacuga aagccgggcu cauuagaacc     5100

cacaucuccc ggugccaggu cuguaugaag aaccuguga                            5139


<210>  7432
<211>  5139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Canstatin__Homo_sapiens__CCDS41907.1

<400>  7432
augggaagag aucaaagggc aguggcggga ccugcacuac gaagaugguu auuauuagga       60

acaguuacag uaggauucuu ggcacaaucu guacuugcag ggguaaaaaa auuugaugua      120

cccugcggag gacgugauug uaguggcggu ugccaauguu acccagaaaa aggugguagg      180

ggucaaccgg gaccaguugg accacaagga uauaauggac caccaggacu acaaggauuu      240

ccuggcuuac aggguagaaa aggcgauaag ggggaaagag gagcuccagg ugucacaggu      300

ccaaaaggcg acguuggagc aagagggguu uccggauuuc ccggggcaga uggaaucccg      360

ggacauccag gucaaggagg uccucgcggu cgaccaggau augacggaug caacgguacu      420

cagggugaca guggaccuca agguccacca gggagugagg gauuuacugg accuccgggu      480

ccgcaagggc cgaaaggaca gaagggagaa ccauacgcgu uaccaaaaga ggaaagggau      540

cgcuauagag gggaaccagg ggaaccaggc uuagugggau uucaaggacc accuggacgc      600

ccaggccaug uaggacaaau gggaccugua ggagccccug gaagacccgg uccgccagga      660

ccaccagguc caaaaggaca acaggggaau cgcggcuuag guuucuaugg aguaaaaggu      720

gaaaaaggag auguugguca acccgguccc aauggaauac cuucagauac acuacaucca      780

auaauagccc caacaggcgu aacauuucau cccgaccaau auaaaggaga aaaagguagu      840

gaaggggaac cuggaauccg cgguauaucc uuaaaaggag aggaaggaau caugggauuu      900

ccaggacucc gagguuaucc uggcuuaagc ggagaaaaag ggucuccggg acaaaaagga      960

ucgagaggac uagacggaua ucaaggaccg gacgguccua gagggccaaa gggagaagca     1020

ggcgacccgg ggccaccagg acucccagca uauucaccac aucccagcuu agccaaagga     1080

gcacgugggg acccgggguu cccaggagcg caaggagaac caggaaguca aggugaacca     1140

ggugauccug guuuaccugg accaccuggu uuaaguauag gagaugguga ucaaaggcga     1200

ggauugcccg gugaaauggg gccuaaggga uuuauaggag auccaggaau accagcacua     1260

uauggagggc cucccggucc agauggaaaa agaggaccac cgggcccucc ggggcuaccu     1320

ggaccaccag gcccugaugg uuucuuauuu gguuuaaaag gagcaaaggg cagagcaggu     1380

uuccccggac uuccaggaag uccuggagcc agagggccua agggauggaa aggagaugcc     1440

ggugaaugua gaugcacuga aggcgaugaa gcaauaaaag gucuuccugg uuuaccuggc     1500

ccgaagggau uugcugguau uaauggagag ccuggaagaa aaggagauag aggggaucca     1560

ggacaacacg guuuaccugg auuuccaggc cuaaaaggag ucccaggaaa uaucggcgca     1620

ccagguccca aaggagcaaa aggggauagu agaacaauua caacuaaggg agaaaggggu     1680

caaccaggag uaccgggagu accaggaaug aagggugacg auggaagucc cgggagagac     1740

ggccuagaug gauuuccagg uuugccggga ccuccagggg acggaauaaa agguccucca     1800

ggagauccag guuaucccgg cauaccaggu accaaaggaa cgccuggcga gaugggucca     1860

ccaggcuuag guuuaccagg auuaaaagga caaaggggau ucccaggcga ugcaggguua     1920

ccgggucccc caggguucuu aggaccaccg ggaccggcag guacuccagg gcaaauugac     1980

ugugauacag auguaaagag agcaguuggu ggagacaggc aagaagcuau acagccuggu     2040

uguauuggug guccuaaagg gcuaccggga cucccagggc ccccaggacc uacaggcgca     2100

aaggguuuac gagguauucc uggcuuugcc ggagcugacg gaggaccugg uccgaggggg     2160

uuaccgggug augcugguag agaaggauuu ccaggcccac caggcuucau ugguccuaga     2220

gguucgaaag gggcaguggg acugccgggu ccugacggaa guccugggcc aauuggacug     2280

ccugguccug augggccucc aggggagaga ggacuaccag gcgaaguucu uggagcgcaa     2340

ccggguccga ggggggacgc cggagugccc ggacaaccag gacuuaaagg ucuaccuggu     2400

gacagaggcc cuccugguuu cagaggaagu caaggcaugc ccgggaugcc aggauugaaa     2460

ggccaaccag gccucccagg accuagcggu caacccgggc uauauggucc ucccggauua     2520

cauggauucc ccggagcacc ggggcaggaa gguccauuag gauuaccagg uauaccuggc     2580

cgugaggguc uuccaggaga cagaggugac ccaggagaua cgggggcgcc uggaccggua     2640

gguaugaaag guuuaagugg agaucgaggu gaugcagguu uuaccggcga acaaggucau     2700

ccuggcaguc ccggguuuaa agguauugau gguaugccgg gaacucccgg auuaaaggga     2760

gaucgagggu ccccgggaau ggauggauuc caaggaaugc ccggauuaaa ggggaggccg     2820

ggcuucccag gaucuaaagg agaagcaggg uuuuucggaa uaccaggcuu aaaaggacug     2880

gcgggagagc caggguucaa agguaguaga ggggauccgg gaccaccugg gccaccacca     2940

gugauauugc cugguaugaa ggauauaaaa ggggagaagg gggaugaggg acccauggga     3000

cuaaaaggau acuuaggagc uaaagggaua cagggaaugc ccgguauacc gggcuuguca     3060

ggaauaccug gucucccugg caggccggga cauauuaaag gaguaaaagg agauauaggg     3120

guuccaggaa uacccggauu accuggauuu ccugguguug cuggaccacc cggaauaacc     3180

ggcuuuccag guuuuauugg caguagagga gauaaaggag cgccuggacg ugccggacuu     3240

uauggagaaa uaggugccac gggugauuuu ggagauaucg gagauacaau aaauuuaccu     3300

ggaagaccug gucuaaaagg ugaaaggggg acuacaggaa uacccggccu uaagggauuu     3360

uuuggggaaa aggguacaga gggagauaua gguuuuccag gaauuacugg agucacaggc     3420

guccaggggc cgcccgguuu aaagggacaa acaggauuuc caggacuaac gggcccuccu     3480

gguagucaag gagaacuggg aagaauagga cuaccaggcg gcaaggguga cgauggaugg     3540

ccaggagcac caggucuacc cggcuuucca ggacuuagag ggauaagagg acuucauggu     3600

cuaccuggaa cuaaaggauu uccaggaagu cccggaucag acauacaugg cgauccuggu     3660

uuuccagguc caccgggaga acgaggggac ccaggagaag caaauacguu gccuggaccg     3720

gucgguguuc caggucaaaa aggugaucaa ggggcuccag gagagcgagg accaccaggu     3780

ucacccggau uacaaggguu uccuggcauu accccgccau cuaauauaag uggugcacca     3840

ggagauaaag gugccccagg uauauucggg uugaaaggcu auagagggcc accaggucca     3900

ccaggcuccg ccgcauuacc aggcucaaaa ggugauacug gaaacccugg ugcaccggga     3960

acuccaggca cgaaggguug ggcgggggau agugguccgc aagguagacc aggaguguuu     4020

ggucuuccag gagaaaaagg accacgugga gaacaaggau uuaugggaaa cacagguccc     4080

acuggagcug ugggagauag agguccaaaa ggacccaaag gggacccugg auuuccaggg     4140

gcuccgggaa cggugggggc uccugguaua gcaggcauuc cucagaaaau agcgguccaa     4200

ccaggaacag uaggaccuca aggucgcaga ggaccaccag gugcaccagg ugaaauggga     4260

ccgcaaggcc ccccaggcga accuggauuu agaggagcuc cugguaaagc agggccacaa     4320

ggccguggug gaguuagugc aguuccaggc uuccgaggag augaaggucc uauagggcau     4380

caaggaccga uaggacagga aggagcucca ggacgcccug guaguccugg auuaccgggu     4440

augccagguc guucgguaag uauuggauac cuauuaguaa agcauucuca aacagaucaa     4500

gagcccaugu gucccguugg aaugaauaaa uuguggagug gguacagcuu auuauauuuc     4560

gagggucaag aaaaagcaca uaaucaggau uuaggauuag ccggguccug uuuagcaaga     4620

uucucgacca ugccuuucuu guacugcaau ccgggugaug uuugcuauua ugcaucacgc     4680

aacgauaagu cauauugguu aaguacaacu gcuccuuugc ccaugaugcc aguagcugag     4740

gaugaaauaa aaccauauau auccagaugu agugucugcg aagcaccggc uauagccaua     4800

gcgguacauu cacaagacgu cagcauccca cauuguccag cgggauggag aucauugugg     4860

auaggauacu cauuucuaau gcacaccgcg gcaggagaug aaggcggugg acaaagcuua     4920

guuucgccag gaucuugccu agaagacuuu agagcuacuc cguuuauaga augcaacggg     4980

ggaaggggaa ccugucauua uuaugcaaau aaguauagcu uuugguuaac uacgauucca     5040

gaacaaaguu uccaaggcuc uccaagcgca gacaccuuga aagcaggguu gaucagaacu     5100

cacauuucac gaugucaagu auguaugaag aauuuauag                            5139


<210>  7433
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Endostatin__Homo_sapiens__Endostatin__Homo_sapiens_

<400>  7433

Met His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu 
1               5                   10                  15      


Asn Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe 
            20                  25                  30          


Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg 
        35                  40                  45              


Ala Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg 
    50                  55                  60                  


Ala Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu 
65                  70                  75                  80  


Phe Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys 
                85                  90                  95      


Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
            100                 105                 110         


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
    130                 135                 140                 


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
145                 150                 155                 160 


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn Ser Phe Met Thr Ala Ser Lys 
            180                 


<210>  7434
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Endostatin__Homo_sapiens__NM_030582.3

<400>  7434
augcacagcc accgcgacuu ccagccggug cuccaccugg uugcgcucaa cagcccccug       60

ucaggcggca ugcggggcau ccgcggggcc gacuuccagu gcuuccagca ggcgcgggcc      120

guggggcugg cgggcaccuu ccgcgccuuc cuguccucgc gccugcagga ccuguacagc      180

aucgugcgcc gugccgaccg cgcagccgug cccaucguca accucaagga cgagcugcug      240

uuucccagcu gggaggcucu guucucaggc ucugaggguc cgcugaagcc cggggcacgc      300

aucuucuccu uugacggcaa ggacguccug aggcacccca ccuggcccca gaagagcgug      360

uggcauggcu cggaccccaa cgggcgcagg cugaccgaga gcuacuguga gacguggcgg      420

acggaggcuc ccucggccac gggccaggcc uccucgcugc uggggggcag gcuccugggg      480

cagagugccg cgagcugcca ucacgccuac aucgugcucu gcauugagaa cagcuucaug      540

acugccucca aguag                                                       555


<210>  7435
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7435
augcacagcc accgcgacuu ccagcccgug cugcaccucg ucgcccugaa cuccccgcug       60

agcggcggga ugcggggcau ccgcggggcc gacuuccagu gcuuccagca ggcgcgggcc      120

gugggccucg ccgggaccuu ccgcgccuuc cuguccagcc ggcugcagga ccucuacucc      180

aucgugcgcc gggccgaccg cgcggccguc cccaucguga accugaagga cgagcuccug      240

uuccccagcu gggaggcccu guucuccggc agcgagggcc cccugaagcc gggggcccgg      300

aucuucuccu ucgacggcaa ggacgugcuc cgccacccca ccuggcccca gaaguccguc      360

uggcacggga gcgaccccaa cggccggcgc cugacggaga gcuacugcga gaccuggcgg      420

accgaggcgc cguccgccac cgggcaggcc agcucccugc ucggcggccg ccugcugggg      480

cagagcgccg ccuccugcca ccacgcguac aucgugcucu gcaucgagaa cagcuucaug      540

acggccucca aguga                                                       555


<210>  7436
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7436
augcacuccc accgcgacuu ccagcccguc cuccaccucg ucgcccucaa cuccccccuc       60

uccggcggca ugcgcggcau ccgcggcgcc gacuuccagu gcuuccagca ggcccgcgcc      120

gucggccucg ccggcaccuu ccgcgccuuc cucuccuccc gccuccagga ccucuacucc      180

aucguccgcc gcgccgaccg cgccgccguc cccaucguca accucaagga cgagcuccuc      240

uuccccuccu gggaggcccu cuucuccggc uccgagggcc cccucaagcc cggcgcccgc      300

aucuucuccu ucgacggcaa ggacguccuc cgccacccca ccuggcccca gaaguccguc      360

uggcacggcu ccgaccccaa cggccgccgc cucaccgagu ccuacugcga gaccuggcgc      420

accgaggccc ccuccgccac cggccaggcc uccucccucc ucggcggccg ccuccucggc      480

caguccgccg ccuccugcca ccacgccuac aucguccucu gcaucgagaa cuccuucaug      540

accgccucca aguga                                                       555


<210>  7437
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7437
augcacagcc auagagacuu ccagcccgug cugcaccucg ucgcccuuaa cuccccucug       60

ucuggcggga ugaggggaau ccggggugcu gauuuucaau gcuuccagca ggcacgcgcc      120

guuggcuugg cggggaccuu ucgagcuuuc uuaucaaguc gucugcagga ccuauacagc      180

auugugagaa gggccgaucg ggcagccgua ccaauaguga aucucaagga cgagcugcuu      240

uuuccguccu gggaagcucu guucucugga ucggagggcc ccuugaaacc uggugcacgc      300

aucuuuucau ucgaugggaa ggacguccuc agacauccaa cauggcccca gaaaagcgug      360

uggcacggaa gugauccuaa cggcaggcgg cugacugaau ccuauuguga gacguggcgc      420

accgaagccc caucugcuac aggccaagcc agcucccugc ucgggggacg auuacugggu      480

cagucagcgg caaguugcca ucacgccuac auuguucuuu guaucgagaa uagcuuuaug      540

acugcuucua aguga                                                       555


<210>  7438
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7438
augcacagcc acagagacuu ccagcccgug cugcaccugg uggcccugaa cagcccccug       60

agcggcggca ugagaggcau cagaggcgcc gacuuccagu gcuuccagca ggccagagcc      120

gugggccugg ccggcaccuu cagagccuuc cugagcagca gacugcagga ccuguacagc      180

aucgugagaa gagccgacag agccgccgug cccaucguga accugaagga cgagcugcug      240

uuccccagcu gggaggcccu guucagcggc agcgagggcc cccugaagcc cggcgccaga      300

aucuucagcu ucgacggcaa ggacgugcug agacacccca ccuggcccca gaagagcgug      360

uggcacggca gcgaccccaa cggcagaaga cugaccgaga gcuacugcga gaccuggaga      420

accgaggccc ccagcgccac cggccaggcc agcagccugc ugggcggcag acugcugggc      480

cagagcgccg ccagcugcca ccacgccuac aucgugcugu gcaucgagaa cagcuucaug      540

accgccagca aguga                                                       555


<210>  7439
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7439
augcacagcc auagagacuu ccagcccgug cugcaccucg ucgcccugaa cuccccucuu       60

ucuggcggga ugcggggaau ccgcggcgcu gauuuucaau gcuuccagca ggccagagcg      120

guugggcugg cuggaaccuu ucgggccuuc cucagcuccc gccugcagga ccuuuacucu      180

auugugagac gggccgaucg cgcugccgug ccgaucguca aucugaagga cgagcuccug      240

uuucccagcu gggaggcucu guucuccggc ucugaggggc cucucaaacc cggagccaga      300

auuuuuagcu ucgauggcaa ggacgugcug cggcauccua cauggcccca aaaauccguu      360

uggcacggca gcgauccuaa cgggcgcaga cuuacggaau cuuauuguga gaccuggcgg      420

acagaagcgc cguccgccac cggacaggcu agcucucugc ucggcgggcg ccugcuugga      480

caguccgccg cuagcugcca ucacgccuac aucgugcugu guauugaaaa uucuuuuaug      540

acagcgucca aguga                                                       555


<210>  7440
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Endostatin__Homo_sapiens__NM_030582.3

<400>  7440
augcauucac auagagauuu ccaacccgua cuacauuuag uagcauuaaa uucaccauua       60

ucaggaggaa ugagaggaau aagaggagca gacuuucaau guuuccaaca agcaagagcu      120

guaggacuag cuggaacauu cagagcauuu uuaagcucaa gacuacaaga cuuauacagu      180

auaguaagac gagcugauag agcagcagua ccaauaguaa auuuaaaaga cgaacuauua      240

uuuccaucau gggaagcacu auuuucagga ucagaaggac cauuaaaacc aggagcaaga      300

auauuuucau uugacggaaa agacguauua agacauccca cauggccaca aaaaagcgua      360

uggcauggau cagacccaaa cggaagaaga cuaacagaau cauacuguga aacauggaga      420

acagaagcac caucagcaac aggacaagca ucaucauuau uaggaggaag acuauuagga      480

caaucagcag caucauguca ccaugcauau auaguacuau guauagaaaa cucauucaug      540

acagcaagca aauaa                                                       555


<210>  7441
<211>  1356
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FLK-1__Homo_sapiens__P35968

<400>  7441

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr 
        995                 1000                1005            


Ser Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys 
    1010                1015                1020                


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn 
1025                1030                1035                1040


Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp 
                1045                1050                1055    


Pro Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met 
            1060                1065                1070        


Ala Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val 
        1075                1080                1085            


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser 
    1090                1095                1100                


Pro Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys 
1105                1110                1115                1120


Glu Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr 
                1125                1130                1135    


Gln Thr Met Leu Asp Cys Trp His Gly Glu Pro Ser Gln Arg Pro Thr 
            1140                1145                1150        


Phe Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala 
        1155                1160                1165            


Gln Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu 
    1170                1175                1180                


Ser Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser 
1185                1190                1195                1200


Cys Met Glu Glu Glu Glu Val Cys Asp Pro Lys Phe His Tyr Asp Asn 
                1205                1210                1215    


Thr Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg 
            1220                1225                1230        


Pro Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu 
        1235                1240                1245            


Val Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu 
    1250                1255                1260                


Ala Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro 
1265                1270                1275                1280


Ser Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser 
                1285                1290                1295    


Glu Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp 
            1300                1305                1310        


Asp Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys 
        1315                1320                1325            


Leu Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln 
    1330                1335                1340                


Pro Asp Ser Gly Thr Thr Leu Ser Ser Pro Pro Val 
1345                1350                1355    


<210>  7442
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FLK-1__Homo_sapiens__AAB88005

<400>  7442
augcagagca aggugcugcu ggccgucgcc cuguggcucu gcguggagac ccgggccgcc       60

ucuguggguu ugccuagugu uucucuugau cugcccaggc ucagcauaca aaaagacaua      120

cuuacaauua aggcuaauac aacucuucaa auuacuugca ggggacagag ggacuuggac      180

uggcuuuggc ccaauaauca gaguggcagu gagcaaaggg uggaggugac ugagugcagc      240

gauggccucu ucuguaagac acucacaauu ccaaaaguga ucggaaauga cacuggagcc      300

uacaagugcu ucuaccggga aacugacuug gccucgguca uuuaugucua uguucaagau      360

uacagaucuc cauuuauugc uucuguuagu gaccaacaug gagucgugua cauuacugag      420

aacaaaaaca aaacuguggu gauuccaugu cucgggucca uuucaaaucu caacguguca      480

cuuugugcaa gauacccaga aaagagauuu guuccugaug guaacagaau uuccugggac      540

agcaagaagg gcuuuacuau ucccagcuac augaucagcu augcuggcau ggucuucugu      600

gaagcaaaaa uuaaugauga aaguuaccag ucuauuaugu acauaguugu cguuguaggg      660

uauaggauuu augauguggu ucugaguccg ucucauggaa uugaacuauc uguuggagaa      720

aagcuugucu uaaauuguac agcaagaacu gaacuaaaug uggggauuga cuucaacugg      780

gaauacccuu cuucgaagca ucagcauaag aaacuuguaa accgagaccu aaaaacccag      840

ucugggagug agaugaagaa auuuuugagc accuuaacua uagauggugu aacccggagu      900

gaccaaggau uguacaccug ugcagcaucc agugggcuga ugaccaagaa gaacagcaca      960

uuugucaggg uccaugaaaa accuuuuguu gcuuuuggaa guggcaugga aucucuggug     1020

gaagccacgg ugggggagcg ugucagaauc ccugcgaagu accuugguua cccaccccca     1080

gaaauaaaau gguauaaaaa uggaauaccc cuugagucca aucacacaau uaaagcgggg     1140

cauguacuga cgauuaugga agugagugaa agagacacag gaaauuacac ugucauccuu     1200

accaauccca uuucaaagga gaagcagagc cauguggucu cucugguugu guauguccca     1260

ccccagauug gugagaaauc ucuaaucucu ccuguggauu ccuaccagua cggcaccacu     1320

caaacgcuga cauguacggu cuaugccauu ccucccccgc aucacaucca cugguauugg     1380

caguuggagg aagagugcgc caacgagccc agccaagcug ucucagugac aaacccauac     1440

ccuugugaag aauggagaag uguggaggac uuccagggag gaaauaaaau ugaaguuaau     1500

aaaaaucaau uugcucuaau ugaaggaaaa aacaaaacug uaaguacccu uguuauccaa     1560

gcggcaaaug ugucagcuuu guacaaaugu gaagcgguca acaaagucgg gagaggagag     1620

agggugaucu ccuuccacgu gaccaggggu ccugaaauua cuuugcaacc ugacaugcag     1680

cccacugagc aggagagcgu gucuuugugg ugcacugcag acagaucuac guuugagaac     1740

cucacauggu acaagcuugg cccacagccu cugccaaucc augugggaga guugcccaca     1800

ccuguuugca agaacuugga uacucuuugg aaauugaaug ccaccauguu cucuaauagc     1860

acaaaugaca uuuugaucau ggagcuuaag aaugcauccu ugcaggacca aggagacuau     1920

gucugccuug cucaagacag gaagaccaag aaaagacauu gcguggucag gcagcucaca     1980

guccuagagc guguggcacc cacgaucaca ggaaaccugg agaaucagac gacaaguauu     2040

ggggaaagca ucgaagucuc augcacggca ucugggaauc ccccuccaca gaucaugugg     2100

uuuaaagaua augagacccu uguagaagac ucaggcauug uauugaagga ugggaaccgg     2160

aaccucacua uccgcagagu gaggaaggag gacgaaggcc ucuacaccug ccaggcaugc     2220

aguguucuug gcugugcaaa aguggaggca uuuuucauaa uagaaggugc ccaggaaaag     2280

acgaacuugg aaaucauuau ucuaguaggc acggcgguga uugccauguu cuucuggcua     2340

cuucuuguca ucauccuacg gaccguuaag cgggccaaug gaggggaacu gaagacaggc     2400

uacuugucca ucgucaugga uccagaugaa cucccauugg augaacauug ugaacgacug     2460

ccuuaugaug ccagcaaaug ggaauucccc agagaccggc ugaagcuagg uaagccucuu     2520

ggccguggug ccuuuggcca agugauugaa gcagaugccu uuggaauuga caagacagca     2580

acuugcagga caguagcagu caaaauguug aaagaaggag caacacacag ugagcaucga     2640

gcucucaugu cugaacucaa gauccucauu cauauugguc accaucucaa uguggucaac     2700

cuucuaggug ccuguaccaa gccaggaggg ccacucaugg ugauugugga auucugcaaa     2760

uuuggaaacc uguccacuua ccugaggagc aagagaaaug aauuuguccc cuacaagacc     2820

aaaggggcac gauuccguca agggaaagac uacguuggag caaucccugu ggaucugaaa     2880

cggcgcuugg acagcaucac caguagccag agcucagcca gcucuggauu uguggaggag     2940

aagucccuca gugauguaga agaagaggaa gcuccugaag aucuguauaa ggacuuccug     3000

accuuggagc aucucaucug uuacagcuuc caaguggcua agggcaugga guucuuggca     3060

ucgcgaaagu guauccacag ggaccuggcg gcacgaaaua uccucuuauc ggagaagaac     3120

gugguuaaaa ucugugacuu uggcuuggcc cgggauauuu auaaagaucc agauuauguc     3180

agaaaaggag augcucgccu cccuuugaaa uggauggccc cagaaacaau uuuugacaga     3240

guguacacaa uccagaguga cgucuggucu uuugguguuu ugcuguggga aauauuuucc     3300

uuaggugcuu cuccauaucc ugggguaaag auugaugaag aauuuuguag gcgauugaaa     3360

gaaggaacua gaaugagggc cccugauuau acuacaccag aaauguacca gaccaugcug     3420

gacugcuggc acggggagcc cagucagaga cccacguuuu cagaguuggu ggaacauuug     3480

ggaaaucucu ugcaagcuaa ugcucagcag gauggcaaag acuacauugu ucuuccgaua     3540

ucagagacuu ugagcaugga agaggauucu ggacucucuc ugccuaccuc accuguuucc     3600

uguauggagg aggaggaagu augugacccc aaauuccauu augacaacac agcaggaauc     3660

agucaguauc ugcagaacag uaagcgaaag agccggccug ugaguguaaa aacauuugaa     3720

gauaucccgu uagaagaacc agaaguaaaa guaaucccag augacaacca gacggacagu     3780

gguaugguuc uugccucaga agagcugaaa acuuuggaag acagaaccaa auuaucucca     3840

ucuuuuggug gaauggugcc cagcaaaagc agggagucug uggcaucuga aggcucaaac     3900

cagacaagcg gcuaccaguc cggauaucac uccgaugaca cagacaccac cguguacucc     3960

agugaggaag cagaacuuuu aaagcugaua gagauuggag ugcaaaccgg uagcacagcc     4020

cagauucucc agccugacuc ggggaccaca cugagcucuc cuccuguuua a              4071


<210>  7443
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7443
augcagagca aggugcugcu cgccgucgcc cuguggcugu gcguggagac ccgcgcggcc       60

uccgugggcc uccccagcgu cucccuggac cugccccggc ucagcaucca gaaggacauc      120

cugaccauca aggccaacac gacccugcag aucacgugcc gcgggcagcg ggaccucgac      180

uggcuguggc ccaacaacca guccggcagc gagcagcgcg uggaggugac cgagugcucc      240

gacgggcugu ucugcaagac ccucaccauc cccaagguca ucggcaacga caccggggcc      300

uacaagugcu ucuaccggga gaccgaccug gccagcguga ucuacgugua cguccaggac      360

uaccgcuccc ccuucaucgc gagcgugucc gaccagcacg gcguggucua caucacggag      420

aacaagaaca agaccguggu gaucccgugc cugggcagca ucuccaaccu caacgucagc      480

cugugcgccc gguaccccga gaagcgcuuc gugcccgacg ggaaccggau cuccugggac      540

agcaagaagg gcuucaccau ccccuccuac augaucagcu acgccgggau gguguucugc      600

gaggccaaga ucaacgacga guccuaccag agcaucaugu acaucgucgu gguggucggc      660

uaccgcaucu acgacguggu gcugagcccg ucccacggga ucgagcucag cgucggcgag      720

aagcuggugc ugaacugcac cgcgcggacg gagcucaacg ucggcaucga cuucaacugg      780

gaguaccccu ccagcaagca ccagcacaag aagcugguga accgcgaccu gaagacccag      840

uccgggagcg agaugaagaa guuccucucc acccugacca ucgacggcgu gacgcggagc      900

gaccaggggc uguacacgug cgccgccucc agcggccuca ugaccaagaa gaacuccacc      960

uucguccgcg ugcacgagaa gcccuucgug gccuucggca gcgggaugga gucccugguc     1020

gaggccaccg ugggcgagcg ggugcgcauc cccgcgaagu accuggggua cccgccgccc     1080

gagaucaagu gguacaagaa cggcaucccc cucgagagca accacaccau caaggccggg     1140

cacguccuga ccaucaugga gguguccgag cgggacaccg gcaacuacac ggugauccug     1200

accaacccga ucagcaagga gaagcagucc cacgucguga gccucguggu cuacgugccg     1260

ccccagaucg gcgagaaguc ccugaucagc cccguggaca gcuaccagua cgggaccacc     1320

cagacgcuga ccugcaccgu cuacgccauc ccgccgcccc accacaucca cugguacugg     1380

cagcucgagg aggagugcgc caacgagccc ucccaggccg ugagcgugac caaccccuac     1440

cccugcgagg aguggcgcuc cgucgaggac uuccagggcg ggaacaagau cgaggugaac     1500

aagaaccagu ucgcgcugau cgagggcaag aacaagacgg ugagcacccu ggucauccag     1560

gccgccaacg uguccgcccu cuacaagugc gaggccguga acaaggucgg gcggggcgag     1620

cgcgugauca gcuuccacgu gacccggggc cccgagauca cccugcagcc cgacaugcag     1680

cccacggagc aggaguccgu cagccugugg ugcaccgcgg accgcuccac cuucgagaac     1740

cucaccuggu acaagcuggg gccccagccc cugccgaucc acgugggcga gcuccccacc     1800

cccgugugca agaaccugga cacgcugugg aagcucaacg ccaccauguu cagcaacucc     1860

accaacgaca uccugaucau ggagcugaag aacgccagcc ugcaggacca gggggacuac     1920

gucugccucg cccaggaccg caagaccaag aagcggcacu gcguggugcg ccagcugacg     1980

guccuggagc ggguggcccc caccaucacc ggcaaccucg agaaccagac cacguccauc     2040

ggggagagca ucgagguguc cugcaccgcg agcggcaacc cgccgcccca gaucaugugg     2100

uucaaggaca acgagacccu ggucgaggac uccggcaucg ugcugaagga cgggaaccgc     2160

aaccucacca uccggcgcgu gcggaaggag gacgagggcc uguacacgug ccaggccugc     2220

agcguccugg ggugcgccaa gguggaggcc uucuucauca ucgagggcgc gcaggagaag     2280

accaaccucg agaucaucau ccuggugggc accgccguca ucgccauguu cuucuggcug     2340

cuccugguga ucauccugcg caccgugaag cgggccaacg ggggcgagcu caagacgggg     2400

uaccugagca ucgucaugga ccccgacgag cugccccucg acgagcacug cgagcgccug     2460

cccuacgacg ccuccaagug ggaguucccc cgggaccgcc ugaagcucgg caagccccug     2520

gggcggggcg cguucggcca ggugaucgag gccgacgccu ucgggaucga caagaccgcg     2580

accugccgca ccguggccgu caagaugcug aaggagggcg ccacgcacag cgagcaccgg     2640

gcccucaugu ccgagcugaa gauccugauc cacaucgggc accaccucaa cguggucaac     2700

cugcugggcg ccugcaccaa gcccgggggc ccccucaugg ugaucgugga guucugcaag     2760

uucggcaacc ugagcaccua ccugcgcucc aagcggaacg aguucguccc cuacaagacc     2820

aagggggccc gcuuccggca gggcaaggac uacguggggg ccauccccgu ggaccucaag     2880

cgccgccugg acagcaucac guccagccag uccagcgcgu ccagcggcuu cgucgaggag     2940

aagucccuga gcgacgugga ggaggaggag gccccggagg accucuacaa ggacuuccug     3000

acccuggagc accucaucug cuacuccuuc cagguggcca aggggaugga guuccuggcc     3060

agccggaagu gcauccaccg cgaccuggcg gcccggaaca uccuccuguc cgagaagaac     3120

gucgugaaga ucugcgacuu cggccuggcc cgcgacaucu acaaggaccc cgacuacgug     3180

cggaagggcg acgcccgccu cccccugaag uggauggccc ccgagaccau cuucgaccgg     3240

gucuacacca uccagagcga cguguggucc uucggggugc ugcucuggga gaucuucagc     3300

cugggcgcga gcccguaccc cggggucaag aucgacgagg aguucugccg ccggcugaag     3360

gagggcacgc gcaugcgggc ccccgacuac accacccccg agauguacca gaccaugcuc     3420

gacugcuggc acggggagcc gucccagcgc cccacguuca gcgagcuggu ggagcaccug     3480

ggcaaccucc ugcaggccaa cgcccagcag gacggcaagg acuacaucgu gcugcccauc     3540

uccgagaccc ucagcaugga ggaggacucc gggcugagcc ugccgaccuc ccccgucagc     3600

ugcauggagg aggaggaggu gugcgacccc aaguuccacu acgacaacac cgccggcauc     3660

ucccaguacc uccagaacag caagcggaag ucccgccccg ugagcgucaa gacguucgag     3720

gacaucccgc uggaggagcc cgaggugaag gugauccccg acgacaacca gaccgacucc     3780

gggauggucc uggcgagcga ggagcucaag acccuggagg accggaccaa gcuguccccc     3840

agcuucggcg gcauggugcc guccaagagc cgcgaguccg uggccagcga ggggagcaac     3900

cagaccuccg gcuaccagag cggguaccac uccgacgaca cggacaccac cgucuacagc     3960

uccgaggagg ccgagcuccu gaagcugauc gagaucggcg ugcagaccgg gagcacggcc     4020

cagauccucc agcccgacuc cggcaccacc cugagcuccc cgcccgugug a              4071


<210>  7444
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7444
augcagucca agguccuccu cgccgucgcc cucuggcucu gcgucgagac ccgcgccgcc       60

uccgucggcc uccccuccgu cucccucgac cucccccgcc ucuccaucca gaaggacauc      120

cucaccauca aggccaacac cacccuccag aucaccugcc gcggccagcg cgaccucgac      180

uggcucuggc ccaacaacca guccggcucc gagcagcgcg ucgaggucac cgagugcucc      240

gacggccucu ucugcaagac ccucaccauc cccaagguca ucggcaacga caccggcgcc      300

uacaagugcu ucuaccgcga gaccgaccuc gccuccguca ucuacgucua cguccaggac      360

uaccgcuccc ccuucaucgc cuccgucucc gaccagcacg gcgucgucua caucaccgag      420

aacaagaaca agaccgucgu cauccccugc cucggcucca ucuccaaccu caacgucucc      480

cucugcgccc gcuaccccga gaagcgcuuc guccccgacg gcaaccgcau cuccugggac      540

uccaagaagg gcuucaccau ccccuccuac augaucuccu acgccggcau ggucuucugc      600

gaggccaaga ucaacgacga guccuaccag uccaucaugu acaucgucgu cgucgucggc      660

uaccgcaucu acgacgucgu ccucuccccc ucccacggca ucgagcucuc cgucggcgag      720

aagcucgucc ucaacugcac cgcccgcacc gagcucaacg ucggcaucga cuucaacugg      780

gaguaccccu ccuccaagca ccagcacaag aagcucguca accgcgaccu caagacccag      840

uccggcuccg agaugaagaa guuccucucc acccucacca ucgacggcgu cacccgcucc      900

gaccagggcc ucuacaccug cgccgccucc uccggccuca ugaccaagaa gaacuccacc      960

uucguccgcg uccacgagaa gcccuucguc gccuucggcu ccggcaugga gucccucguc     1020

gaggccaccg ucggcgagcg cguccgcauc cccgccaagu accucggcua cccccccccc     1080

gagaucaagu gguacaagaa cggcaucccc cucgagucca accacaccau caaggccggc     1140

cacguccuca ccaucaugga ggucuccgag cgcgacaccg gcaacuacac cgucauccuc     1200

accaacccca ucuccaagga gaagcagucc cacgucgucu cccucgucgu cuacgucccc     1260

ccccagaucg gcgagaaguc ccucaucucc cccgucgacu ccuaccagua cggcaccacc     1320

cagacccuca ccugcaccgu cuacgccauc cccccccccc accacaucca cugguacugg     1380

cagcucgagg aggagugcgc caacgagccc ucccaggccg ucuccgucac caaccccuac     1440

cccugcgagg aguggcgcuc cgucgaggac uuccagggcg gcaacaagau cgaggucaac     1500

aagaaccagu ucgcccucau cgagggcaag aacaagaccg ucuccacccu cgucauccag     1560

gccgccaacg ucuccgcccu cuacaagugc gaggccguca acaaggucgg ccgcggcgag     1620

cgcgucaucu ccuuccacgu cacccgcggc cccgagauca cccuccagcc cgacaugcag     1680

cccaccgagc aggaguccgu cucccucugg ugcaccgccg accgcuccac cuucgagaac     1740

cucaccuggu acaagcucgg cccccagccc cuccccaucc acgucggcga gcuccccacc     1800

cccgucugca agaaccucga cacccucugg aagcucaacg ccaccauguu cuccaacucc     1860

accaacgaca uccucaucau ggagcucaag aacgccuccc uccaggacca gggcgacuac     1920

gucugccucg cccaggaccg caagaccaag aagcgccacu gcgucguccg ccagcucacc     1980

guccucgagc gcgucgcccc caccaucacc ggcaaccucg agaaccagac caccuccauc     2040

ggcgagucca ucgaggucuc cugcaccgcc uccggcaacc ccccccccca gaucaugugg     2100

uucaaggaca acgagacccu cgucgaggac uccggcaucg uccucaagga cggcaaccgc     2160

aaccucacca uccgccgcgu ccgcaaggag gacgagggcc ucuacaccug ccaggccugc     2220

uccguccucg gcugcgccaa ggucgaggcc uucuucauca ucgagggcgc ccaggagaag     2280

accaaccucg agaucaucau ccucgucggc accgccguca ucgccauguu cuucuggcuc     2340

cuccucguca ucauccuccg caccgucaag cgcgccaacg gcggcgagcu caagaccggc     2400

uaccucucca ucgucaugga ccccgacgag cucccccucg acgagcacug cgagcgccuc     2460

cccuacgacg ccuccaagug ggaguucccc cgcgaccgcc ucaagcucgg caagccccuc     2520

ggccgcggcg ccuucggcca ggucaucgag gccgacgccu ucggcaucga caagaccgcc     2580

accugccgca ccgucgccgu caagaugcuc aaggagggcg ccacccacuc cgagcaccgc     2640

gcccucaugu ccgagcucaa gauccucauc cacaucggcc accaccucaa cgucgucaac     2700

cuccucggcg ccugcaccaa gcccggcggc ccccucaugg ucaucgucga guucugcaag     2760

uucggcaacc ucuccaccua ccuccgcucc aagcgcaacg aguucguccc cuacaagacc     2820

aagggcgccc gcuuccgcca gggcaaggac uacgucggcg ccauccccgu cgaccucaag     2880

cgccgccucg acuccaucac cuccucccag uccuccgccu ccuccggcuu cgucgaggag     2940

aagucccucu ccgacgucga ggaggaggag gcccccgagg accucuacaa ggacuuccuc     3000

acccucgagc accucaucug cuacuccuuc caggucgcca agggcaugga guuccucgcc     3060

ucccgcaagu gcauccaccg cgaccucgcc gcccgcaaca uccuccucuc cgagaagaac     3120

gucgucaaga ucugcgacuu cggccucgcc cgcgacaucu acaaggaccc cgacuacguc     3180

cgcaagggcg acgcccgccu cccccucaag uggauggccc ccgagaccau cuucgaccgc     3240

gucuacacca uccaguccga cgucuggucc uucggcgucc uccucuggga gaucuucucc     3300

cucggcgccu cccccuaccc cggcgucaag aucgacgagg aguucugccg ccgccucaag     3360

gagggcaccc gcaugcgcgc ccccgacuac accacccccg agauguacca gaccaugcuc     3420

gacugcuggc acggcgagcc cucccagcgc cccaccuucu ccgagcucgu cgagcaccuc     3480

ggcaaccucc uccaggccaa cgcccagcag gacggcaagg acuacaucgu ccuccccauc     3540

uccgagaccc ucuccaugga ggaggacucc ggccucuccc uccccaccuc ccccgucucc     3600

ugcauggagg aggaggaggu cugcgacccc aaguuccacu acgacaacac cgccggcauc     3660

ucccaguacc uccagaacuc caagcgcaag ucccgccccg ucuccgucaa gaccuucgag     3720

gacauccccc ucgaggagcc cgaggucaag gucauccccg acgacaacca gaccgacucc     3780

ggcauggucc ucgccuccga ggagcucaag acccucgagg accgcaccaa gcucuccccc     3840

uccuucggcg gcaugguccc cuccaagucc cgcgaguccg ucgccuccga gggcuccaac     3900

cagaccuccg gcuaccaguc cggcuaccac uccgacgaca ccgacaccac cgucuacucc     3960

uccgaggagg ccgagcuccu caagcucauc gagaucggcg uccagaccgg cuccaccgcc     4020

cagauccucc agcccgacuc cggcaccacc cucuccuccc cccccgucug a              4071


<210>  7445
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7445
augcagagca aggugcugcu cgccgucgcu cuuuggcugu gcguugagac cagagcagcc       60

uccgugggcu ugcccucugu aucauuagac cugccuaggc uaaguaucca aaaagauauu      120

cucacaauaa aggcgaacac uacgcugcag aucaccuguc gggggcagcg cgaccuugau      180

uggcuguggc caaauaacca gagcggaucc gaacaacgag uggaggucac agaaugcucu      240

gacgguuugu ucuguaaaac ucucaccauu ccgaagguga ucggcaauga uacaggggcu      300

uacaaaugcu uuuaucguga gaccgaccug gccucgguua uuuacgugua uguccaggau      360

uacagaucac ccuucaucgc aagcgugagu gaccagcacg gaguaguuua uauaacugaa      420

aacaagaaua agacaguggu caucccuugu cugggcucca uuucuaaccu caaugugagc      480

uuaugcgcca gguacccaga gaaacgguuu gugcccgaug guaaccgcau cuccugggac      540

ucaaagaaag gguucaccau uccuaguuau augaucagcu acgcuggaau ggucuuuugu      600

gaggcaaaga uaaaugauga aucuuaccag uccauuaugu auaucguugu gguagugggc      660

uacagaauuu augacgucgu gcugucacca agccauggca ucgagcuuag uguuggggaa      720

aaauuggugc ugaacugcac ggccaggacu gagcuaaaug ucggaaucga uuucaacugg      780

gaguaccccu cuuccaagca ccaacauaag aaacucguga aucgggaccu gaagacccag      840

agcgguucgg aaaugaaaaa guuucuuucu acacugacua uugacggcgu aacccgcucc      900

gaucaggggu uguauacaug ugcugccuca aguggacuca ugaccaaaaa gaacagcacg      960

uucguucgag ugcacgagaa accuuuuguc gcguucggcu ccgguaugga aucucuggug     1020

gaggcaacug ucggggaaag agugaggaua ccagccaagu acuuaggaua uccgcccccu     1080

gagaucaagu gguacaaaaa uggcauucca cuggagagca accauacaau caaggcuggc     1140

cacguucuca ccauaaugga agugucagag cgggacacug ggaacuacac aguaauucuu     1200

accaauccca ucaguaaaga aaagcagucc cacgucguga gccugguugu guaugucccu     1260

ccacaaaucg gagagaaauc uuugauuuca cccguggaua guuaccagua ugguacgacc     1320

cagacacuaa cuugcaccgu auacgccauc ccgccucccc aucacauuca uugguauugg     1380

caacuggaag aggagugugc aaacgaacca agccaggcug uguccguuac aaauccuuac     1440

cccugcgagg aauggcguuc ugucgaggac uuucagggcg ggaacaagau agaagugaau     1500

aagaaccagu ucgcccucau cgagggcaaa aauaagacug ugucgacccu ggucauucaa     1560

gcggccaacg uuagcgcacu uuauaaaugc gaggcuguga auaagguggg acgcggugaa     1620

agaguaaucu ccuuucacgu cacaaggggg ccagagauca cccugcagcc cgauaugcag     1680

ccuacugaac aggagucagu gaguuugugg uguacggccg accggucuac auucgagaac     1740

cucaccuggu acaaacuggg cccacaaccg uuacccauuc acguuggaga acugccuacu     1800

ccagugugca agaaucuaga uacccucugg aagcugaacg cuacaauguu cagcaauucc     1860

accaacgaca uacuuaucau ggaguugaaa aaugccucac ugcaggauca gggcgacuac     1920

gucugucucg cacaggaucg aaagacuaaa aagcgccauu gcgugguuag acaacugaca     1980

gugcuugaaa ggguagcccc cacgauuacc gggaaccugg agaaccagac uacaagcauc     2040

ggagaaucua uugaggucuc cuguaccgcu agugguaauc cuccacccca gaucaugugg     2100

uuuaaagaca acgagacauu gguggaagac agcggcauag ugcucaagga ugggaaucgg     2160

aaccugacua uccgcagagu caggaaggag gacgaaggau uauauaccug ccaggcgugu     2220

ucuguucugg gcugcgcaaa aguggaggcc uucuuuauua ucgaaggugc ucaagagaag     2280

acgaaucuag agauuaucau acucguaggg accgccguga uugcaauguu cuuuuggcug     2340

cuuuugguca ucauucugcg uacagugaaa cgggccaacg gcggagaacu caagacuggc     2400

uaccugucca ucguuaugga uccggacgag uuaccucugg augaacacug ugagcgacuu     2460

ccauaugacg cuucaaaaug ggaauuuccc agagauaggu ugaagcucgg gaaaccucug     2520

ggacgcggug ccuuuggcca ggugauagag gcagacgcgu ucgggaucga uaagaccgcu     2580

acaugccgga cugucgccgu gaagaugcua aaagagggag caacccauag ugaacacaga     2640

gcccugauga gcgagcucaa gauucugauc cauauuggcc accaccuuaa uguugugaac     2700

uugcugggug cuuguacgaa acccgggggc ccauuaaugg ucaucguaga auuuugcaag     2760

uucggaaauc ucucgacaua ccugaggucc aaacgcaacg aguuugugcc uuauaagacc     2820

aagggcgccc gauuccggca ggggaaagac uacguuggag caauacccgu ggaucuuaag     2880

cguagacugg acucuauuac uagcucacaa aguuccgcuu cuagcggcuu ugucgaggaa     2940

aaauccuugu cagaugugga ggaagaggaa gccccagagg accucuauaa ggacuuccug     3000

acacuagagc aucugaucug cuacagcuuc cagguagcga aagguaugga auuucucgcc     3060

aguaggaagu guauccaccg cgaucuggcu gcacggaaua uucuuuuguc ugagaagaac     3120

guggucaaaa ucugcgacuu cgggcuggcc agagauauuu acaaggaccc ggauuauguu     3180

aggaaaggag acgcucgauu accucucaag uggauggccc ccgaaaccau auuugaucgc     3240

guguacacua uccaguccga cguguggagc uucggcgucc ugcuuuggga gauuuucucg     3300

cugggugcau caccauaucc cggcgugaaa aucgaugaag aguucugucg gagacuaaag     3360

gaggggacca ggaugcgugc gccugacuac acaacgccag aaauguauca gaccaugcuc     3420

gauugcuggc auggagagcc cucucaacgc ccuacuuuua gugaacuggu ugagcacuug     3480

ggcaaucugu uacaggccaa cgcucagcag gacgggaagg auuacauugu acucccgauc     3540

uccgaaacac ugagcaugga ggaggacucu ggacuuagcc ugccaaccuc ccccguguca     3600

uguauggaag aggaagaggu cugcgacccu aaauuccacu augauaauac agccggcaua     3660

agucaauacu ugcagaacag caagcggaaa ucuagaccag uguccguuaa gacuuuugag     3720

gacauccccc ucgaggaacc ugaagugaaa gucauuccgg augacaacca gaccgauuca     3780

gguauggugc uggcaaguga ggaacuaaag acgcuggagg acaggacaaa acuuagcccc     3840

uccuucgggg gaaugguacc aucuaagucg cgagagagcg ucgcuucaga aggcuccaau     3900

cagaccagug guuaccaauc uggcuaucau agcgaugaca cugauaccac aguguacucc     3960

ucagaggaag ccgagcuccu gaaguugauc gaaauugggg uucagacugg aucuaccgca     4020

cagauccugc aaccugacag cggcacaacg uuaaguuccc cacccgugug a              4071


<210>  7446
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7446
augcagagca aggugcugcu ggccguggcc cuguggcugu gcguggagac cagagccgcc       60

agcgugggcc ugcccagcgu gagccuggac cugcccagac ugagcaucca gaaggacauc      120

cugaccauca aggccaacac cacccugcag aucaccugca gaggccagag agaccuggac      180

uggcuguggc ccaacaacca gagcggcagc gagcagagag uggaggugac cgagugcagc      240

gacggccugu ucugcaagac ccugaccauc cccaagguga ucggcaacga caccggcgcc      300

uacaagugcu ucuacagaga gaccgaccug gccagcguga ucuacgugua cgugcaggac      360

uacagaagcc ccuucaucgc cagcgugagc gaccagcacg gcguggugua caucaccgag      420

aacaagaaca agaccguggu gauccccugc cugggcagca ucagcaaccu gaacgugagc      480

cugugcgcca gauaccccga gaagagauuc gugcccgacg gcaacagaau cagcugggac      540

agcaagaagg gcuucaccau ccccagcuac augaucagcu acgccggcau gguguucugc      600

gaggccaaga ucaacgacga gagcuaccag agcaucaugu acaucguggu gguggugggc      660

uacagaaucu acgacguggu gcugagcccc agccacggca ucgagcugag cgugggcgag      720

aagcuggugc ugaacugcac cgccagaacc gagcugaacg ugggcaucga cuucaacugg      780

gaguacccca gcagcaagca ccagcacaag aagcugguga acagagaccu gaagacccag      840

agcggcagcg agaugaagaa guuccugagc acccugacca ucgacggcgu gaccagaagc      900

gaccagggcc uguacaccug cgccgccagc agcggccuga ugaccaagaa gaacagcacc      960

uucgugagag ugcacgagaa gcccuucgug gccuucggca gcggcaugga gagccuggug     1020

gaggccaccg ugggcgagag agugagaauc cccgccaagu accugggcua cccccccccc     1080

gagaucaagu gguacaagaa cggcaucccc cuggagagca accacaccau caaggccggc     1140

cacgugcuga ccaucaugga ggugagcgag agagacaccg gcaacuacac cgugauccug     1200

accaacccca ucagcaagga gaagcagagc cacgugguga gccugguggu guacgugccc     1260

ccccagaucg gcgagaagag ccugaucagc cccguggaca gcuaccagua cggcaccacc     1320

cagacccuga ccugcaccgu guacgccauc cccccccccc accacaucca cugguacugg     1380

cagcuggagg aggagugcgc caacgagccc agccaggccg ugagcgugac caaccccuac     1440

cccugcgagg aguggagaag cguggaggac uuccagggcg gcaacaagau cgaggugaac     1500

aagaaccagu ucgcccugau cgagggcaag aacaagaccg ugagcacccu ggugauccag     1560

gccgccaacg ugagcgcccu guacaagugc gaggccguga acaagguggg cagaggcgag     1620

agagugauca gcuuccacgu gaccagaggc cccgagauca cccugcagcc cgacaugcag     1680

cccaccgagc aggagagcgu gagccugugg ugcaccgccg acagaagcac cuucgagaac     1740

cugaccuggu acaagcuggg cccccagccc cugcccaucc acgugggcga gcugcccacc     1800

cccgugugca agaaccugga cacccugugg aagcugaacg ccaccauguu cagcaacagc     1860

accaacgaca uccugaucau ggagcugaag aacgccagcc ugcaggacca gggcgacuac     1920

gugugccugg cccaggacag aaagaccaag aagagacacu gcguggugag acagcugacc     1980

gugcuggaga gaguggcccc caccaucacc ggcaaccugg agaaccagac caccagcauc     2040

ggcgagagca ucgaggugag cugcaccgcc agcggcaacc ccccccccca gaucaugugg     2100

uucaaggaca acgagacccu gguggaggac agcggcaucg ugcugaagga cggcaacaga     2160

aaccugacca ucagaagagu gagaaaggag gacgagggcc uguacaccug ccaggccugc     2220

agcgugcugg gcugcgccaa gguggaggcc uucuucauca ucgagggcgc ccaggagaag     2280

accaaccugg agaucaucau ccuggugggc accgccguga ucgccauguu cuucuggcug     2340

cugcugguga ucauccugag aaccgugaag agagccaacg gcggcgagcu gaagaccggc     2400

uaccugagca ucgugaugga ccccgacgag cugccccugg acgagcacug cgagagacug     2460

cccuacgacg ccagcaagug ggaguucccc agagacagac ugaagcuggg caagccccug     2520

ggcagaggcg ccuucggcca ggugaucgag gccgacgccu ucggcaucga caagaccgcc     2580

accugcagaa ccguggccgu gaagaugcug aaggagggcg ccacccacag cgagcacaga     2640

gcccugauga gcgagcugaa gauccugauc cacaucggcc accaccugaa cguggugaac     2700

cugcugggcg ccugcaccaa gcccggcggc ccccugaugg ugaucgugga guucugcaag     2760

uucggcaacc ugagcaccua ccugagaagc aagagaaacg aguucgugcc cuacaagacc     2820

aagggcgcca gauucagaca gggcaaggac uacgugggcg ccauccccgu ggaccugaag     2880

agaagacugg acagcaucac cagcagccag agcagcgcca gcagcggcuu cguggaggag     2940

aagagccuga gcgacgugga ggaggaggag gcccccgagg accuguacaa ggacuuccug     3000

acccuggagc accugaucug cuacagcuuc cagguggcca agggcaugga guuccuggcc     3060

agcagaaagu gcauccacag agaccuggcc gccagaaaca uccugcugag cgagaagaac     3120

guggugaaga ucugcgacuu cggccuggcc agagacaucu acaaggaccc cgacuacgug     3180

agaaagggcg acgccagacu gccccugaag uggauggccc ccgagaccau cuucgacaga     3240

guguacacca uccagagcga cguguggagc uucggcgugc ugcuguggga gaucuucagc     3300

cugggcgcca gccccuaccc cggcgugaag aucgacgagg aguucugcag aagacugaag     3360

gagggcacca gaaugagagc ccccgacuac accacccccg agauguacca gaccaugcug     3420

gacugcuggc acggcgagcc cagccagaga cccaccuuca gcgagcuggu ggagcaccug     3480

ggcaaccugc ugcaggccaa cgcccagcag gacggcaagg acuacaucgu gcugcccauc     3540

agcgagaccc ugagcaugga ggaggacagc ggccugagcc ugcccaccag ccccgugagc     3600

ugcauggagg aggaggaggu gugcgacccc aaguuccacu acgacaacac cgccggcauc     3660

agccaguacc ugcagaacag caagagaaag agcagacccg ugagcgugaa gaccuucgag     3720

gacauccccc uggaggagcc cgaggugaag gugauccccg acgacaacca gaccgacagc     3780

ggcauggugc uggccagcga ggagcugaag acccuggagg acagaaccaa gcugagcccc     3840

agcuucggcg gcauggugcc cagcaagagc agagagagcg uggccagcga gggcagcaac     3900

cagaccagcg gcuaccagag cggcuaccac agcgacgaca ccgacaccac cguguacagc     3960

agcgaggagg ccgagcugcu gaagcugauc gagaucggcg ugcagaccgg cagcaccgcc     4020

cagauccugc agcccgacag cggcaccacc cugagcagcc cccccgugug a              4071


<210>  7447
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7447
augcagagca aggugcugcu cgccgucgcu cuguggcuuu gcguugagac cagagccgcg       60

uccgugggcc ugcccucugu gagccucgac cugccucggc uuuccaucca aaaagauauu      120

cugacaauca aggcuaacac gacccuccag auuacauguc gcgggcagag agaccuggau      180

uggcuguggc cgaauaacca gucuggaagc gaacaacggg ucgaggugac cgaaugcucc      240

gacggccucu ucuguaaaac acugaccauc cccaagguua uugggaauga uacaggagcc      300

uacaaaugcu uuuaucgcga gaccgaccuu gccucuguga ucuacgucua ugugcaggau      360

uacagaagcc cuuucaucgc uuccguuagc gaccagcacg gcguggucua uauuacggaa      420

aacaagaaua agaccguggu gauccccugu cuggggucua uuuccaaccu caaugucagc      480

cugugcgccc gguacccuga gaaacgcuuu guucccgaug gaaacagaau cucuugggac      540

uccaagaaag gcuucacaau uccuagcuau augaucucuu acgcuggcau gguguuuugu      600

gaggccaaga uuaaugauga auccuaccag agcaucaugu auaucguggu cgugguuggg      660

uaccggauuu augacguggu ccuuuccccg ucucauggaa ucgagcugag cgugggcgaa      720

aaacucguuc ugaacugcac cgcgcgcaca gagcugaaug uggggauuga uuucaacugg      780

gaguaccccu ccagcaagca ccaacauaag aaacucguca auagagaccu gaagacccag      840

ucuggauccg aaaugaaaaa guuucuuagc acgcugacaa ucgacggcgu gacccggucu      900

gaucaggggc ucuauacaug ugccgcuagc uccggacuga ugaccaaaaa gaacucuacc      960

uucguccgcg ugcacgagaa accuuuuguu gccuucggca gcggcaugga aucccuugug     1020

gaggcuacag ucggggaaag agugcggauu cccgccaagu accugggaua uccucccccg     1080

gagaucaagu gguacaaaaa uggcaucccu cucgagagca accauacgau uaaggcgggg     1140

cacguucuga ccaucaugga agugucugag cgcgacacag gaaacuacac cgucauucug     1200

acaaauccca ucuccaaaga aaagcagagc cacguggugu cucucguugu cuaugugccu     1260

ccccaaauug gcgagaaauc ccugaucagc cccguggauu ccuaccagua ugggaccacg     1320

cagacacuua ccugcaccgu cuacgccauc ccuccgcccc aucacauuca uugguauugg     1380

caacuggaag aggagugugc uaacgaaccu ucucaggccg ugagcguuac aaaucccuac     1440

ccuugcgagg aauggagauc cguggaggac uuucagggag gcaacaagau cgaagucaau     1500

aagaaccagu ucgcucucau ugagggcaaa aauaagaccg ugucuacacu gguuauccaa     1560

gccgccaacg ugagcgcucu uuauaaaugc gaggcgguca auaagguggg gcggggagaa     1620

agaguuauuu ccuuucacgu gacgcgcggc cccgagauca cccugcagcc ggauaugcag     1680

ccuacagaac aggagagcgu cucucucugg uguaccgccg accgguccac auucgagaac     1740

cugaccuggu acaaacuggg gccccaaccu cuccccauuc acgugggaga acugccuacg     1800

cccgugugca agaaucuuga uacccugugg aagcucaacg cuacaauguu cagcaauucu     1860

accaacgaca uccugaucau ggagcugaaa aaugccuccc uucaggauca gggcgacuac     1920

gucugucucg cccaggauag aaagacaaag aagcgccauu gcguugugcg gcaacugacc     1980

gugcuggaaa gagucgcucc gacgauuaca gggaaccucg agaaccagac cacaagcauc     2040

ggcgaaucua uugaggugag cuguaccgcc uccggaaauc cuccucccca gaucaugugg     2100

uuuaaagaca acgagacccu gguugaagac agcggcauug ugcuuaagga ugggaaucgc     2160

aaccugacaa uccggagagu ccgcaaggag gacgaaggac ucuauacgug ccaggcgugu     2220

ucugugcugg gcugcgcuaa aguugaggcc uucuuuauca uugaaggggc ccaagagaag     2280

accaaucugg agaucauuau ccuuguggga acagcuguca uugccauguu cuuuuggcuc     2340

cugcugguga ucauccuccg gaccguuaaa agagcuaacg gcggggaacu gaagacaggc     2400

uaccuuucca uugugaugga ucccgacgag cugccgcucg augaacacug ugagcgccug     2460

cccuaugacg ccagcaaaug ggaauuuccu cgggauagac ugaaacuugg aaaaccccuc     2520

ggccgcgggg cguuuggaca ggucaucgag gccgacgcuu ucggcauuga uaagaccgcc     2580

acgugccgga caguggcugu gaagaugcug aaagaggggg ccacccauuc cgaacacaga     2640

gcgcugaugu cugagcucaa gauccugauu cauaucggac accaccuuaa ugucguuaac     2700

cugcucggcg ccuguaccaa accugggggc ccccugaugg ugaucgugga auuuugcaag     2760

uucggaaauc ugagcacaua ccuucggucc aaaagaaacg aguuuguccc uuauaagacc     2820

aagggcgcuc gcuuccggca ggggaaagac uacgugggag ccauucccgu ugaucucaag     2880

agacgccugg acucuaucac aagcucccaa ucuagcgcuu ccagcggcuu uguggaggaa     2940

aaaucucugu ccgaugucga ggaagaggaa gccccggagg accucuauaa ggacuuccug     3000

acgcuugagc aucugauuug cuacagcuuc cagguggcca aagggaugga auuucucgcu     3060

ucuagaaagu guauccaccg ggaucuggcg gcccgcaaua uucugcuuuc cgagaagaac     3120

guugugaaaa ucugcgacuu cggacuggcu agagauauuu acaaggaccc ugauuauguc     3180

cggaaaggcg acgcccgccu cccccugaag uggauggccc cugaaaccau cuuugauaga     3240

guguacacaa uccagagcga cgucuggucu uucggggugc uccuguggga gauuuucucc     3300

cuuggcgcua gccccuaucc gggaguuaaa aucgaugaag aguucugucg gcgccugaag     3360

gagggcacca gaaugcgggc cccugacuac acaacccccg aaauguauca gacgaugcuc     3420

gauugcuggc auggggagcc uucccaacgc cccaccuuua gcgaacuggu ggagcaccug     3480

ggaaaucuuc ugcaggcgaa cgcucagcag gacggcaagg auuacauugu ccuccccauc     3540

ucugaaacac ugagcaugga ggaggacucc gggcucucuc ugccuaccag cccggugucc     3600

uguauggaag aggaagaggu uugcgacccc aaauuccacu augauaauac agccggaauu     3660

ucucaauacc uucagaacag caagagaaaa ucccggccug ugucugucaa gaccuuugag     3720

gacauccccc uggaggaacc ugaagugaaa gugauccccg augacaacca gacagauagc     3780

ggcaugguuc ucgccuccga ggaacugaag acccuggagg acagaacgaa acuuagcccu     3840

ucuuucggcg ggaugguccc guccaagagc cgcgagucug uggcuuccga aggaagcaau     3900

cagacauccg gcuaccaauc uggguaucau agcgaugaca ccgauaccac aguguacucc     3960

agcgaggaag ccgagcugcu caagcugauu gaaaucggag uccagaccgg cucuacggcg     4020

cagauucucc aacccgacuc cgggacaacc cugagcucuc cucccgugug a              4071


<210>  7448
<211>  4071
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       FLK-1__Homo_sapiens__AAB88005

<400>  7448
augcaaucca aagugcuacu ugccgucgcu uuguggcuau guguagaaac acgagcagca       60

ucuguuggcu uacccuccgu cucacuagac cugccaagac uauccauaca gaaagauaua      120

uuaacaauaa aagcuaacac aacccuucaa aucacuuguc gaggacaaag agaucuagac      180

uggcuguggc cuaauaauca auccgguagu gaacaaagag ucgaaguaac ggagugcuca      240

gauggacuau ucuguaaaac ucuaacgaua ccaaaaguaa uaggaaauga uacuggugca      300

uauaaauguu uuuauagaga aacugacuua gcaucgguaa uauauguaua cguacaagau      360

uauagaucgc cauucauagc uucuguuuca gaccagcaug gagucguaua uauaacugag      420

aauaaaaaua aaaccgucgu cauaccuugc cuaggaucaa uuaguaauuu aaacguuagc      480

cuuugugcaa gauaucccga aaaacgcuuc gucccagaug gaaaucgaau aaguugggau      540

ucuaaaaaag gauuuacaau accgagcuac augauaucuu acgcaggaau gguauuuugu      600

gaagcaaaaa ucaaugauga aucuuaccaa ucaauuaugu auauaguggu aguaguuggc      660

uacaggauau augauguagu ucuaucaccc ucccauggua uagaauuauc gguaggagaa      720

aaauuaguac uuaauuguac cgcaagaaca gaacuaaaug uugggauaga cuucaauugg      780

gaauacccgu ccaguaagca ucaacacaaa aaacuaguua auagagaccu caaaacacaa      840

ucggguuccg agaugaaaaa guucuuguca acacucacga uugacggagu uacaaggucg      900

gaccaagguc ucuauacaug cgcagcaagu ucaggcuuaa ugaccaaaaa aaacucuaca      960

uuuguuagag uucaugaaaa accuuuuguu gcauuuggau cgggcaugga aagccuagua     1020

gaagcaacug uaggggaacg gguaagaaua cccgcuaagu acuuaggaua cccacccccu     1080

gaaauaaaau gguauaaaaa cggaauacca uuagaaucca aucauacaau uaaagcagga     1140

cacguacuca caauaaugga aguaagugaa agagauacag gaaauuacac cgucauccua     1200

acuaacccca uaucaaaaga aaaacaaucu cacguagucu cacugguugu uuauguacca     1260

ccacaaauag gagaaaaauc acuaaucuca ccugucgauu cauaucagua uggaacaacc     1320

caaacauuaa ccuguacagu uuaugccaua ccaccuccac accacauaca uugguacugg     1380

caauuagaag aagaaugugc caaugaaccu ucacaagcug ugagcgugac aaauccuuau     1440

ccgugugaag aguggcguuc aguagaggac uuucaaggug guaacaaaau ugagguaaau     1500

aaaaaccaau uugcauuaau ugaaggcaaa aacaaaacag uuucuacucu aguuauacaa     1560

gcugcaaaug ucuccgcacu auauaagugc gaagcaguaa auaagguagg ucgcggagaa     1620

aggguaaucu ccuuucacgu aacacgugga ccagaaauua cccuacaacc ggauaugcaa     1680

ccuacagaac aggaaucggu uucacuaugg uguacagcag acagaucuac uuucgagaac     1740

cucacauggu acaaacuagg cccacaacca uuacccauuc acguagguga auuaccgaca     1800

ccaguaugua aaaaucuaga cacauuaugg aaacuaaacg cuaccauguu uuccaauuca     1860

acaaaugaca uacucauuau ggaguuaaaa aacgcaucau uacaagauca aggagauuac     1920

guuugccuag cacaagacag gaaaacuaaa aaaaggcacu gcguggucag acaacuuaca     1980

guccuagaaa gaguagcucc aacaauuaca ggaaaucugg aaaaucagac aacaucuauc     2040

ggugaaagca uagaagucuc augcacagca ucuggaaacc ccccaccaca gauuaugugg     2100

uuuaaagaca augaaacauu aguagaggau ucaggaauug ucuuaaagga cgggaauaga     2160

aaucuaacaa ucaggagagu uaggaaagaa gaugaaggau uauacacaug ucaagcaugu     2220

ucaguauuag gaugugcaaa gguagaagcu uuuuucauca ucgaaggagc ccaagaaaaa     2280

acaaaucuug aaauaauaau auuaguugga acagcaguaa uugcuauguu uuucugguua     2340

cuccuuguaa uaauacuucg uacaguaaaa agagcuaaug gaggagaacu caaaacuggu     2400

uauuuaagua uaguaaugga uccagaugag cuaccccuag augaacauug ugaacgucua     2460

ccauacgaug ccucuaaaug ggaauuuccc agagaccggu uaaaacuagg aaaacccuua     2520

ggacgcggcg cauucggaca gguuauagaa gcagaugcuu uugguauaga uaaaaccgca     2580

acaugcagaa caguugcggu gaaaauguua aaagaaggcg ccacacacuc ggaacacaga     2640

gcauuaaugu cagaacuaaa aauccuuauc cauauugguc accaccuaaa cguaguaaac     2700

uuacuaggag cguguacuaa gccuggcgga ccauuaaugg uaauugucga auuuugcaaa     2760

uuuggaaauu uaucaacuua uuuaagaucu aaacgaaaug aauuuguacc auacaaaaca     2820

aaaggagcac gcuuuagaca aggaaaagau uauguaggag caauaccagu agaccuaaaa     2880

aggagacucg auuccauaac aaguagucaa ucaagcgcau ccaguggauu cguggaagaa     2940

aaaagccuau cagauguaga agaggaagaa gcaccagaag accuauauaa agauuuucua     3000

accuuagaac aucuuauaug uuacuccuuu caaguugcaa aagguaugga auuucuagcu     3060

ucacguaaau gcauacaucg agaucuugcg gcaagaaaca uauuacuauc ggaaaaaaau     3120

guagucaaaa uaugugauuu cggucucgcu agggauauau acaaagaccc ugacuaugua     3180

cgaaaaggag augcaagacu accacuaaaa uggauggcac ccgaaacgau uuucgacagg     3240

guauacacaa uccaaucaga uguauggucc uuugguguau uacuguggga aauuuuuucu     3300

cuaggcgcaa gcccuuaucc gggcgucaaa aucgacgaag aauuuugcag aagauuaaaa     3360

gaggggacac ggaugcgugc uccagauuau acaacaccag aaauguacca gacaauguug     3420

gacugcuggc acggagagcc cagucaaaga cccacuuucu cagaguuggu ugagcaccuu     3480

ggaaaucuuu ugcaagcuaa ugcucaacaa gauggaaagg auuacauagu acuaccuaua     3540

agugaaacuu uauccaugga agaagacagu ggguuaucac uaccaaccag uccaguaucu     3600

ugcauggagg aagaagaagu cugugauccu aaauuucacu augacaacac agcuggaauc     3660

ucacaguauc uacaaaauuc aaaaagaaaa ucacgaccug uguccgucaa aacauuugag     3720

gauauaccuc uagaagaacc cgaaguaaag guaauaccag acgauaauca gacagauucg     3780

ggaaugguuc ucgcaucaga agaauuaaaa acauuagaag aucguaccaa acuaucucca     3840

agcuuuggcg guaugguacc uucaaaaucc cgcgaaucug uagcaucaga aggaucgaac     3900

caaacuucag gcuaccaauc aggguaccau ucagacgaua cagauacaac gguauacuca     3960

agcgaggaag cagaacuacu aaaauuaaua gaaauaggag uccaaacggg cucaaccgca     4020

caaauuuuac aaccggacag cgguacaacg uuaaguagcc caccugugua a              4071


<210>  7449
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PEX__Homo_sapiens__P78562

<400>  7449

Met Glu Ala Glu Thr Gly Ser Ser Val Glu Thr Gly Lys Lys Ala Asn 
1               5                   10                  15      


Arg Gly Thr Arg Ile Ala Leu Val Val Phe Val Gly Gly Thr Leu Val 
            20                  25                  30          


Leu Gly Thr Ile Leu Phe Leu Val Ser Gln Gly Leu Leu Ser Leu Gln 
        35                  40                  45              


Ala Lys Gln Glu Tyr Cys Leu Lys Pro Glu Cys Ile Glu Ala Ala Ala 
    50                  55                  60                  


Ala Ile Leu Ser Lys Val Asn Leu Ser Val Asp Pro Cys Asp Asn Phe 
65                  70                  75                  80  


Phe Arg Phe Ala Cys Asp Gly Trp Ile Ser Asn Asn Pro Ile Pro Glu 
                85                  90                  95      


Asp Met Pro Ser Tyr Gly Val Tyr Pro Trp Leu Arg His Asn Val Asp 
            100                 105                 110         


Leu Lys Leu Lys Glu Leu Leu Glu Lys Ser Ile Ser Arg Arg Arg Asp 
        115                 120                 125             


Thr Glu Ala Ile Gln Lys Ala Lys Ile Leu Tyr Ser Ser Cys Met Asn 
    130                 135                 140                 


Glu Lys Ala Ile Glu Lys Ala Asp Ala Lys Pro Leu Leu His Ile Leu 
145                 150                 155                 160 


Arg His Ser Pro Phe Arg Trp Pro Val Leu Glu Ser Asn Ile Gly Pro 
                165                 170                 175     


Glu Gly Val Trp Ser Glu Arg Lys Phe Ser Leu Leu Gln Thr Leu Ala 
            180                 185                 190         


Thr Phe Arg Gly Gln Tyr Ser Asn Ser Val Phe Ile Arg Leu Tyr Val 
        195                 200                 205             


Ser Pro Asp Asp Lys Ala Ser Asn Glu His Ile Leu Lys Leu Asp Gln 
    210                 215                 220                 


Ala Thr Leu Ser Leu Ala Val Arg Glu Asp Tyr Leu Asp Asn Ser Thr 
225                 230                 235                 240 


Glu Ala Lys Ser Tyr Arg Asp Ala Leu Tyr Lys Phe Met Val Asp Thr 
                245                 250                 255     


Ala Val Leu Leu Gly Ala Asn Ser Ser Arg Ala Glu His Asp Met Lys 
            260                 265                 270         


Ser Val Leu Arg Leu Glu Ile Lys Ile Ala Glu Ile Met Ile Pro His 
        275                 280                 285             


Glu Asn Arg Thr Ser Glu Ala Met Tyr Asn Lys Met Asn Ile Ser Glu 
    290                 295                 300                 


Leu Ser Ala Met Ile Pro Gln Phe Asp Trp Leu Gly Tyr Ile Lys Lys 
305                 310                 315                 320 


Val Ile Asp Thr Arg Leu Tyr Pro His Leu Lys Asp Ile Ser Pro Ser 
                325                 330                 335     


Glu Asn Val Val Val Arg Val Pro Gln Tyr Phe Lys Asp Leu Phe Arg 
            340                 345                 350         


Ile Leu Gly Ser Glu Arg Lys Lys Thr Ile Ala Asn Tyr Leu Val Trp 
        355                 360                 365             


Arg Met Val Tyr Ser Arg Ile Pro Asn Leu Ser Arg Arg Phe Gln Tyr 
    370                 375                 380                 


Arg Trp Leu Glu Phe Ser Arg Val Ile Gln Gly Thr Thr Thr Leu Leu 
385                 390                 395                 400 


Pro Gln Trp Asp Lys Cys Val Asn Phe Ile Glu Ser Ala Leu Pro Tyr 
                405                 410                 415     


Val Val Gly Lys Met Phe Val Asp Val Tyr Phe Gln Glu Asp Lys Lys 
            420                 425                 430         


Glu Met Met Glu Glu Leu Val Glu Gly Val Arg Trp Ala Phe Ile Asp 
        435                 440                 445             


Met Leu Glu Lys Glu Asn Glu Trp Met Asp Ala Gly Thr Lys Arg Lys 
    450                 455                 460                 


Ala Lys Glu Lys Ala Arg Ala Val Leu Ala Lys Val Gly Tyr Pro Glu 
465                 470                 475                 480 


Phe Ile Met Asn Asp Thr His Val Asn Glu Asp Leu Lys Ala Ile Lys 
                485                 490                 495     


Phe Ser Glu Ala Asp Tyr Phe Gly Asn Val Leu Gln Thr Arg Lys Tyr 
            500                 505                 510         


Leu Ala Gln Ser Asp Phe Phe Trp Leu Arg Lys Ala Val Pro Lys Thr 
        515                 520                 525             


Glu Trp Phe Thr Asn Pro Thr Thr Val Asn Ala Phe Tyr Ser Ala Ser 
    530                 535                 540                 


Thr Asn Gln Ile Arg Phe Pro Ala Gly Glu Leu Gln Lys Pro Phe Phe 
545                 550                 555                 560 


Trp Gly Thr Glu Tyr Pro Arg Ser Leu Ser Tyr Gly Ala Ile Gly Val 
                565                 570                 575     


Ile Val Gly His Glu Phe Thr His Gly Phe Asp Asn Asn Gly Arg Lys 
            580                 585                 590         


Tyr Asp Lys Asn Gly Asn Leu Asp Pro Trp Trp Ser Thr Glu Ser Glu 
        595                 600                 605             


Glu Lys Phe Lys Glu Lys Thr Lys Cys Met Ile Asn Gln Tyr Ser Asn 
    610                 615                 620                 


Tyr Tyr Trp Lys Lys Ala Gly Leu Asn Val Lys Gly Lys Arg Thr Leu 
625                 630                 635                 640 


Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Arg Glu Ala Phe Arg Ala 
                645                 650                 655     


Tyr Arg Lys Trp Ile Asn Asp Arg Arg Gln Gly Leu Glu Glu Pro Leu 
            660                 665                 670         


Leu Pro Gly Ile Thr Phe Thr Asn Asn Gln Leu Phe Phe Leu Ser Tyr 
        675                 680                 685             


Ala His Val Arg Cys Asn Ser Tyr Arg Pro Glu Ala Ala Arg Glu Gln 
    690                 695                 700                 


Val Gln Ile Gly Ala His Ser Pro Pro Gln Phe Arg Val Asn Gly Ala 
705                 710                 715                 720 


Ile Ser Asn Phe Glu Glu Phe Gln Lys Ala Phe Asn Cys Pro Pro Asn 
                725                 730                 735     


Ser Thr Met Asn Arg Gly Met Asp Ser Cys Arg Leu Trp 
            740                 745                 


<210>  7450
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PEX__Homo_sapiens__AAB47562

<400>  7450
auggaagcag aaacagggag cagcguggag acuggaaaga aggccaacag aggcacucga       60

auugcccugg ucguguuugu cgguggcacc cuaguucugg gcacgauccu cuuucuagug      120

agucaagguc ucuuaagucu ccaagcuaaa caggaguacu gccugaagcc agaaugcauc      180

gaagcggcug cugccaucuu aaguaaagua aaucugucug uggauccuug ugauaauuuc      240

uuccgguucg cuugugaugg cuggauaagc aauaauccaa uucccgaaga uaugccaagc      300

uaugggguuu auccuuggcu gagacauaau guugaccuca aguugaagga acuuuuggag      360

aaaucaauca guagaaggcg ggacaccgaa gccauacaga aagccaaaau ccuuuauuca      420

uccugcauga augagaaagc gauugaaaaa gcagaugcca agccacugcu acacauccua      480

cggcauucac cuuuccgcug gcccgugcuu gaaucuaaua uuggcccuga agggguuugg      540

ucagagagaa aguucagccu ucugcagaca cuugcaacgu uucgugguca auacagcaau      600

ucuguguuca uccguuugua uguguccccu gaugacaaag cauccaauga acauaucuug      660

aagcuggacc aagcaacacu cucccuggcc gugagggaag acuaccuuga uaacaguaca      720

gaagccaagu cuuaucggga ugcccuuuac aaguucaugg uggauacugc cgugcuuuua      780

ggagcuaaca guuccagagc agagcaugac augaagucag ugcucagauu ggaaauuaag      840

auagcugaga uaaugauucc acaugaaaac cgaaccagcg aggccaugua caacaaaaug      900

aacauuucug aacugagugc uaugauuccc caguucgacu ggcugggcua caucaagaag      960

gucauugaca ccagacucua cccccaucug aaagacauca gccccuccga gaauguggug     1020

guccgcgucc cgcaguacuu uaaagauuug uuuaggauau uagggucuga gagaaagaag     1080

accauugcca acuauuuggu guggagaaug guuuauucca gaauuccaaa ccuuagcagg     1140

cgcuuucagu auagauggcu ggaauucuca aggguaaucc aggggaccac aacuuugcug     1200

ccucaauggg acaaaugugu aaacuuuauu gaaagugccc ucccuuaugu uguuggaaag     1260

auguuuguag auguguacuu ccaggaagau aagaaggaaa ugauggagga auugguugag     1320

ggcguucgcu gggccuuuau ugacaugcua gagaaagaaa augaguggau ggaugcagga     1380

acgaaaagga aagccaaaga aaaggcgaga gcuguuuugg caaaaguugg cuauccagag     1440

uuuauaauga augauacuca uguuaaugaa gaccucaaag cuaucaaguu uucagaagcc     1500

gacuacuuug gcaacguccu acaaacucgc aaguauuuag cacagucuga uuucuucugg     1560

cuaagaaaag ccguuccaaa aacagagugg uuuacaaauc cgacgacugu caaugccuuc     1620

uacagugcau ccaccaacca gauccgauuu ccagcaggag agcuccagaa gccuuucuuu     1680

uggggaacag aauauccucg aucucugagu uauggugcua uaggaguaau ugucggacau     1740

gaauuuacac auggauucga uaauaauggu agaaaauaug auaaaaaugg aaaccuggau     1800

ccuugguggu cuacugaauc agaagaaaag uuuaaggaaa aaacaaaaug caugauuaac     1860

caguauagca acuauuauug gaagaaagcu ggcuuaaaug ucaaggggaa gaggacccug     1920

ggagaaaaua uugcugauaa uggaggccug cgggaagcuu uuagggcuua caggaaaugg     1980

auaaaugaca gaaggcaggg acuugaggag ccucuucuac caggcaucac auucaccaac     2040

aaccagcucu ucuuccugag uuaugcucau gugaggugca auuccuacag accagaagcu     2100

gcccgagaac aaguccaaau uggugcucac agucccccuc aguuuagggu caauggugca     2160

auuaguaacu uugaagaauu ccagaaagcu uuuaacuguc cacccaauuc cacgaugaac     2220

agaggcaugg acuccugccg acucugguag                                      2250


<210>  7451
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PEX__Homo_sapiens__AAB47562

<400>  7451
auggaggccg agaccggcag cuccguggag accgggaaga aggccaaccg cggcacgcgg       60

aucgcgcugg ugguguucgu cgggggcacc cucgugcugg ggaccauccu guuccucgug      120

agccagggcc ugcugucccu ccaggccaag caggaguacu gccugaagcc cgagugcauc      180

gaggccgccg ccgcgauccu gagcaaggug aaccucuccg ucgacccgug cgacaacuuc      240

uuccgcuucg ccugcgacgg cuggaucagc aacaacccca uccccgagga caugcccucc      300

uacggggugu acccguggcu gcggcacaac guggaccuga agcucaagga gcugcuggag      360

aaguccauca gccgccggcg cgacaccgag gccauccaga aggccaagau ccucuacagc      420

uccugcauga acgagaaggc gaucgagaag gccgacgcca agccccugcu gcacauccuc      480

cggcacagcc ccuuccgcug gcccguccug gaguccaaca ucggcccgga gggggugugg      540

agcgagcgga aguucucccu gcuccagacg cuggccaccu uccgcggcca guacagcaac      600

uccguguuca uccggcugua cgucagcccc gacgacaagg ccuccaacga gcacauccuc      660

aagcuggacc aggcgacccu gagccucgcc gugcgcgagg acuaccugga caacagcacc      720

gaggccaagu ccuaccggga cgcccuguac aaguucaugg uggacacggc cguccuccug      780

ggggcgaaca gcucccgcgc cgagcacgac augaaguccg ugcugcggcu cgagaucaag      840

aucgccgaga ucaugauccc ccacgagaac cgcaccagcg aggccaugua caacaagaug      900

aacaucagcg agcuguccgc caugaucccc caguucgacu ggcugggcua caucaagaag      960

gugaucgaca cccggcucua cccgcaccug aaggacauca gccccuccga gaacgucgug     1020

gugcgcgucc cccaguacuu caaggaccug uuccggaucc ucggcagcga gcgcaagaag     1080

accaucgcga acuaccuggu guggcggaug guguacuccc gcauccccaa ccugagccgc     1140

cgguuccagu accgcuggcu cgaguucucc cgggucaucc aggggacgac cacccugcug     1200

ccgcaguggg acaagugcgu gaacuucauc gagagcgccc uccccuacgu cgugggcaag     1260

auguucgugg acgucuacuu ccaggaggac aagaaggaga ugauggagga gcugguggag     1320

ggggugcgcu gggccuucau cgacaugcug gagaaggaga acgaguggau ggacgccggc     1380

accaagcgga aggccaagga gaaggcgcgc gccguccucg ccaagguggg cuaccccgag     1440

uucaucauga acgacacgca cgugaacgag gaccugaagg ccaucaaguu cuccgaggcg     1500

gacuacuucg ggaacguccu gcagacccgg aaguaccugg cccagagcga cuucuucugg     1560

cuccgcaagg ccgugcccaa gaccgagugg uucaccaacc cgacgaccgu gaacgccuuc     1620

uacuccgcca gcaccaacca gauccgguuc cccgcgggcg agcugcagaa gcccuucuuc     1680

ugggggaccg aguacccccg cucccugagc uacggcgcca ucggggucau cgugggccac     1740

gaguucacgc acggcuucga caacaacggg cggaaguacg acaagaacgg caaccucgac     1800

ccguggugga gcaccgaguc cgaggagaag uucaaggaga agaccaagug caugaucaac     1860

caguacagca acuacuacug gaagaaggcc gggcugaacg ugaagggcaa gcgcacccug     1920

ggggagaaca ucgccgacaa cggcggccuc cgggaggccu uccgcgcgua ccggaagugg     1980

aucaacgacc gccggcaggg gcuggaggag ccccugcucc ccggcaucac guucaccaac     2040

aaccagcugu ucuuccuguc cuacgcccac guccgcugca acagcuaccg gcccgaggcc     2100

gcccgcgagc agguccagau cggggcccac uccccgcccc aguuccgcgu gaacggcgcg     2160

aucagcaacu ucgaggaguu ccagaaggcc uucaacugcc cgcccaacuc caccaugaac     2220

cgggggaugg acagcugccg ccucugguga                                      2250


<210>  7452
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PEX__Homo_sapiens__AAB47562

<400>  7452
auggaggccg agaccggcuc cuccgucgag accggcaaga aggccaaccg cggcacccgc       60

aucgcccucg ucgucuucgu cggcggcacc cucguccucg gcaccauccu cuuccucguc      120

ucccagggcc uccucucccu ccaggccaag caggaguacu gccucaagcc cgagugcauc      180

gaggccgccg ccgccauccu cuccaagguc aaccucuccg ucgaccccug cgacaacuuc      240

uuccgcuucg ccugcgacgg cuggaucucc aacaacccca uccccgagga caugcccucc      300

uacggcgucu accccuggcu ccgccacaac gucgaccuca agcucaagga gcuccucgag      360

aaguccaucu cccgccgccg cgacaccgag gccauccaga aggccaagau ccucuacucc      420

uccugcauga acgagaaggc caucgagaag gccgacgcca agccccuccu ccacauccuc      480

cgccacuccc ccuuccgcug gcccguccuc gaguccaaca ucggccccga gggcgucugg      540

uccgagcgca aguucucccu ccuccagacc cucgccaccu uccgcggcca guacuccaac      600

uccgucuuca uccgccucua cgucuccccc gacgacaagg ccuccaacga gcacauccuc      660

aagcucgacc aggccacccu cucccucgcc guccgcgagg acuaccucga caacuccacc      720

gaggccaagu ccuaccgcga cgcccucuac aaguucaugg ucgacaccgc cguccuccuc      780

ggcgccaacu ccucccgcgc cgagcacgac augaaguccg uccuccgccu cgagaucaag      840

aucgccgaga ucaugauccc ccacgagaac cgcaccuccg aggccaugua caacaagaug      900

aacaucuccg agcucuccgc caugaucccc caguucgacu ggcucggcua caucaagaag      960

gucaucgaca cccgccucua cccccaccuc aaggacaucu cccccuccga gaacgucguc     1020

guccgcgucc cccaguacuu caaggaccuc uuccgcaucc ucggcuccga gcgcaagaag     1080

accaucgcca acuaccucgu cuggcgcaug gucuacuccc gcauccccaa ccucucccgc     1140

cgcuuccagu accgcuggcu cgaguucucc cgcgucaucc agggcaccac cacccuccuc     1200

ccccaguggg acaagugcgu caacuucauc gaguccgccc uccccuacgu cgucggcaag     1260

auguucgucg acgucuacuu ccaggaggac aagaaggaga ugauggagga gcucgucgag     1320

ggcguccgcu gggccuucau cgacaugcuc gagaaggaga acgaguggau ggacgccggc     1380

accaagcgca aggccaagga gaaggcccgc gccguccucg ccaaggucgg cuaccccgag     1440

uucaucauga acgacaccca cgucaacgag gaccucaagg ccaucaaguu cuccgaggcc     1500

gacuacuucg gcaacguccu ccagacccgc aaguaccucg cccaguccga cuucuucugg     1560

cuccgcaagg ccguccccaa gaccgagugg uucaccaacc ccaccaccgu caacgccuuc     1620

uacuccgccu ccaccaacca gauccgcuuc cccgccggcg agcuccagaa gcccuucuuc     1680

uggggcaccg aguacccccg cucccucucc uacggcgcca ucggcgucau cgucggccac     1740

gaguucaccc acggcuucga caacaacggc cgcaaguacg acaagaacgg caaccucgac     1800

cccugguggu ccaccgaguc cgaggagaag uucaaggaga agaccaagug caugaucaac     1860

caguacucca acuacuacug gaagaaggcc ggccucaacg ucaagggcaa gcgcacccuc     1920

ggcgagaaca ucgccgacaa cggcggccuc cgcgaggccu uccgcgccua ccgcaagugg     1980

aucaacgacc gccgccaggg ccucgaggag ccccuccucc ccggcaucac cuucaccaac     2040

aaccagcucu ucuuccucuc cuacgcccac guccgcugca acuccuaccg ccccgaggcc     2100

gcccgcgagc agguccagau cggcgcccac uccccccccc aguuccgcgu caacggcgcc     2160

aucuccaacu ucgaggaguu ccagaaggcc uucaacugcc cccccaacuc caccaugaac     2220

cgcggcaugg acuccugccg ccucugguga                                      2250


<210>  7453
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PEX__Homo_sapiens__AAB47562

<400>  7453
auggaagccg aaaccggcag cuccguggag acagggaaga aagcuaacag aggaacuagg       60

aucgcacugg ucguuuucgu ggguggcacg cucguacuug ggaccauucu guuuuuggug      120

ucucagggau uacugucacu acaagccaag caggaauacu gccucaaacc cgaguguaua      180

gaagcggcug ccgcaauccu gaguaagguc aaucuuagcg uggacccuug cgauaacuuc      240

uuucgguucg ccugugacgg cuggauuucc aauaacccaa ucccggagga uaugcccucu      300

uaugguguuu acccuuggcu gcgccacaau guggacuuga aacucaagga gcugcuggaa      360

aagucgauuu cacgacguag agauacagag gcuauccaga aagcaaagau acucuauagc      420

aguugcauga acgaaaaagc caucgagaag gcugacgcca aaccauuacu gcauauucuu      480

aggcacuccc ccuuucggug gccugucuug gagucuaaua ucgggccaga aggagugugg      540

agcgagcgca aguucucccu gcuacagacu cucgcgaccu uuagaggcca auacucaaac      600

aguguauuca uuaggcugua uguuagcccc gaugacaagg caucuaauga acauauccuu      660

aaacuggauc aggccacauu gucccucgcu gugcgggagg acuaccugga uaacucaacc      720

gaagccaaga gcuaucgcga cgcauuauac aaauuuaugg ucgauacugc ugugcugcuc      780

ggcgccaaua guucucgagc ggagcacgac augaaguccg ugcuuagacu ggagauaaaa      840

auugccgaaa ucaugauucc ucaugagaac aggacaagcg aagcaaugua caauaagaug      900

aacaucucgg aguugucugc uaugauccca caguucgacu ggcuagggua uauuaaaaag      960

gucauagaua cccggcugua cccgcaccuc aaggacaucu cccccucaga aaauguugug     1020

guacgugugc cucaguauuu uaaagaucug uuccgcauuc uuggaaguga gagaaagaaa     1080

acgaucgcca acuaccuggu cuggaggaug guguauagcc ggauaccaaa cuugucccga     1140

cgcuuucaau acagauggcu cgaguucucu aggguuauuc aggguacuac cacacuguua     1200

ccccaguggg acaagugugu gaauuucauc gaaagcgcuc ugccuuaugu cgugggcaaa     1260

auguuuguag auguuuacuu ccaggaggac aagaaggaaa ugauggagga acucguggag     1320

gggguccggu gggccuuuau cgauaugcuc gagaaagaaa acgaguggau ggacgcagga     1380

acuaagcgca aagccaagga aaaagcuaga gcggugcugg caaaggucgg cuacccagag     1440

uucauuauga augauaccca cgugaacgag gaccuuaagg ccaucaaauu uucagaagcu     1500

gauuauuucg guaauguuuu gcaaacaagg aaguaccugg cccagaguga cuuuuucugg     1560

cuccguaaag cagugcccaa gaccgagugg uuuacgaacc cgacuacagu aaaugccuuc     1620

uauuccgcua gcaccaacca gauucgguuu ccugccgggg aacugcaaaa acccuucuuu     1680

uggggaacug aguacccacg aucucuuuca uauggcgcaa uaggcgucau cguggggcau     1740

gaguucacac acggauucga caauaacggu agaaaguacg auaagaaugg caaccuggac     1800

ccuuggugga guaccgagag cgaggaaaaa uuuaaggaga aaacgaagug caugauuaau     1860

caguauucca acuacuacug gaaaaaggcg ggguugaaug uuaaaggaaa gaggacccuc     1920

ggcgaaaaca ucgcugauaa cggugggcug cgcgaggccu uccgggcaua uagaaagugg     1980

aucaaugaca ggcgccaggg cuuagaagaa ccccugcuac caggaauuac auuuacuaac     2040

aaucagcuau ucuuucuguc uuacgcccau gugcgaugua acucguaucg gcccgaggcu     2100

gcccgugaac aaguccagau aggcgcacac agcccuccac aguucagagu gaauggggcu     2160

aucuccaacu uugaggaguu ccagaaagcc uuuaauugcc cgcccaacuc aaccaugaau     2220

aggggaaugg auaguugucg ccuuugguga                                      2250


<210>  7454
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PEX__Homo_sapiens__AAB47562

<400>  7454
auggaggccg agaccggcag cagcguggag accggcaaga aggccaacag aggcaccaga       60

aucgcccugg ugguguucgu gggcggcacc cuggugcugg gcaccauccu guuccuggug      120

agccagggcc ugcugagccu gcaggccaag caggaguacu gccugaagcc cgagugcauc      180

gaggccgccg ccgccauccu gagcaaggug aaccugagcg uggaccccug cgacaacuuc      240

uucagauucg ccugcgacgg cuggaucagc aacaacccca uccccgagga caugcccagc      300

uacggcgugu accccuggcu gagacacaac guggaccuga agcugaagga gcugcuggag      360

aagagcauca gcagaagaag agacaccgag gccauccaga aggccaagau ccuguacagc      420

agcugcauga acgagaaggc caucgagaag gccgacgcca agccccugcu gcacauccug      480

agacacagcc ccuucagaug gcccgugcug gagagcaaca ucggccccga gggcgugugg      540

agcgagagaa aguucagccu gcugcagacc cuggccaccu ucagaggcca guacagcaac      600

agcguguuca ucagacugua cgugagcccc gacgacaagg ccagcaacga gcacauccug      660

aagcuggacc aggccacccu gagccuggcc gugagagagg acuaccugga caacagcacc      720

gaggccaaga gcuacagaga cgcccuguac aaguucaugg uggacaccgc cgugcugcug      780

ggcgccaaca gcagcagagc cgagcacgac augaagagcg ugcugagacu ggagaucaag      840

aucgccgaga ucaugauccc ccacgagaac agaaccagcg aggccaugua caacaagaug      900

aacaucagcg agcugagcgc caugaucccc caguucgacu ggcugggcua caucaagaag      960

gugaucgaca ccagacugua cccccaccug aaggacauca gccccagcga gaacguggug     1020

gugagagugc cccaguacuu caaggaccug uucagaaucc ugggcagcga gagaaagaag     1080

accaucgcca acuaccuggu guggagaaug guguacagca gaauccccaa ccugagcaga     1140

agauuccagu acagauggcu ggaguucagc agagugaucc agggcaccac cacccugcug     1200

ccccaguggg acaagugcgu gaacuucauc gagagcgccc ugcccuacgu ggugggcaag     1260

auguucgugg acguguacuu ccaggaggac aagaaggaga ugauggagga gcugguggag     1320

ggcgugagau gggccuucau cgacaugcug gagaaggaga acgaguggau ggacgccggc     1380

accaagagaa aggccaagga gaaggccaga gccgugcugg ccaagguggg cuaccccgag     1440

uucaucauga acgacaccca cgugaacgag gaccugaagg ccaucaaguu cagcgaggcc     1500

gacuacuucg gcaacgugcu gcagaccaga aaguaccugg cccagagcga cuucuucugg     1560

cugagaaagg ccgugcccaa gaccgagugg uucaccaacc ccaccaccgu gaacgccuuc     1620

uacagcgcca gcaccaacca gaucagauuc cccgccggcg agcugcagaa gcccuucuuc     1680

uggggcaccg aguaccccag aagccugagc uacggcgcca ucggcgugau cgugggccac     1740

gaguucaccc acggcuucga caacaacggc agaaaguacg acaagaacgg caaccuggac     1800

cccuggugga gcaccgagag cgaggagaag uucaaggaga agaccaagug caugaucaac     1860

caguacagca acuacuacug gaagaaggcc ggccugaacg ugaagggcaa gagaacccug     1920

ggcgagaaca ucgccgacaa cggcggccug agagaggccu ucagagccua cagaaagugg     1980

aucaacgaca gaagacaggg ccuggaggag ccccugcugc ccggcaucac cuucaccaac     2040

aaccagcugu ucuuccugag cuacgcccac gugagaugca acagcuacag acccgaggcc     2100

gccagagagc aggugcagau cggcgcccac agcccccccc aguucagagu gaacggcgcc     2160

aucagcaacu ucgaggaguu ccagaaggcc uucaacugcc cccccaacag caccaugaac     2220

agaggcaugg acagcugcag acugugguga                                      2250


<210>  7455
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PEX__Homo_sapiens__AAB47562

<400>  7455
auggaagccg aaaccggcag cuccguggag acagggaaga aagcuaacag aggaacgcgg       60

aucgcccugg ucguuuucgu gggcgggacc cucgugcugg gaacaauucu uuuucugguc      120

ucucagggcc uccugagccu ucaagcgaag caggaauacu gccugaaacc cgaguguauc      180

gaagcugccg ccgcuauucu cuccaaggug aaucugucug uugacccuug cgauaacuuc      240

uuucgcuucg ccugugacgg guggaucagc aauaacccga uucccgagga uaugccuucc      300

uauggagugu accccuggcu gagacacaau gucgaccuca aacugaagga gcuucuggaa      360

aagucuauca gccggcgcag agauaccgag gcuauccaga aagccaagau ucucuauucc      420

agcugcauga acgaaaaagc gaucgagaag gccgacgcua aaccucugcu ucauauucug      480

cggcacucuc ccuuucgcug gccugugcuc gaguccaaua ucggcccgga aggcguuugg      540

agcgagagaa aguucucucu gcugcagaca cucgccaccu uucgggggca auacuccaac      600

agcguguuca uucgccugua ugucucuccc gaugacaagg cuuccaauga acauauccuu      660

aaacuggauc aggccacacu cagccuggcg gugagagagg acuaccuuga uaacuccacc      720

gaagccaagu cuuaucggga cgcucuguac aaauuuaugg uggauacggc cguccuccug      780

ggagcuaaua gcucccgcgc cgagcacgac augaaaagcg uucugagacu cgagauuaag      840

aucgccgaaa ucaugauucc ucaugagaac cggaccucug aagcuaugua caauaagaug      900

aacaucuccg agcugagcgc gaugauuccc caguucgacu ggcuuggcua uaucaaaaag      960

gugauugaua cacgccugua cccucaccuc aaggacaucu cucccagcga aaaugugguc     1020

gugagaguuc cgcaguauuu uaaagaucug uuccggaucc uuggguccga gagaaagaaa     1080

accauugcca acuaccuggu guggcgcaug gucuauucuc ggaucccuaa ccucagcaga     1140

cgcuuucaau accgguggcu ggaguucucc agagugauuc agggaacaac cacgcugcuc     1200

ccccaguggg acaagugugu uaauuucauc gaaagcgcuc ugccuuaugu ggucggcaaa     1260

auguuugugg augucuacuu ccaggaggac aagaaggaaa ugauggagga acuuguggag     1320

gggguucgcu gggccuuuau ugauaugcug gagaaagaaa acgaguggau ggacgccgga     1380

acaaagcgga aagcuaagga aaaagccaga gcggugcucg cuaaggucgg cuaccccgag     1440

uucaucauga augauaccca cgugaacgag gaccugaagg ccaucaaauu uucugaagcc     1500

gauuauuucg gcaauguucu gcaaacacgc aaguaccuug cucaguccga cuuuuucugg     1560

cuccggaaag ccgugcccaa gaccgagugg uuuaccaacc cuacaacggu caaugcuuuc     1620

uauagcgccu cuaccaacca gauuagauuu ccggcggggg aacugcaaaa acccuucuuu     1680

uggggaacag aguacccucg cucccugagc uauggcgcca ucggggugau ugugggacau     1740

gaguucaccc acggcuucga caauaacggg cggaaguacg auaagaaugg aaaccucgac     1800

cccugguggu ccacagaguc ugaggaaaaa uuuaaggaga aaaccaagug caugaucaau     1860

caguauagca acuacuacug gaaaaaggcu ggccugaaug uuaaaggcaa gagaacgcuu     1920

ggggaaaaca uugccgauaa cggaggccug cgggaggcuu uccgcgccua uagaaagugg     1980

aucaaugacc ggagacaggg gcucgaagaa ccucugcugc ccggaauuac auuuaccaac     2040

aaucagcuuu ucuuucucuc cuacgcgcau guccgcugua acucuuaucg gccggaggcc     2100

gcuagagaac aagugcagau cggcgcccac agcccucccc aguuccgcgu gaauggggcu     2160

aucuccaacu uugaggaguu ccagaaagcc uuuaauugcc cucccaacag caccaugaau     2220

agaggcaugg auucuugucg gcugugguga                                      2250


<210>  7456
<211>  2250
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       PEX__Homo_sapiens__AAB47562

<400>  7456
auggaagcag aaaccggcuc aagcguagaa acagguaaaa aagcaaauag aggaacaaga       60

auagcauuag uaguauucgu aggaggaaca uuaguauuag gcaccauacu auuccuagua      120

agucagggac uccuuagccu ucaagccaaa caagaauacu guuuaaaacc agaauguauu      180

gaagcagcag cagcaauauu aucaaaagua aacuuaucag uagacccaug cgacaacuuc      240

uuccgcuuug caugcgaugg auggauuagc aauaauccca uacccgaaga caugccgagc      300

uauggcguau auccauggcu uagacauaac guagacuuaa aauuaaaaga acuucucgaa      360

aaaucaauau caagaagaag agacacagaa gcaauacaaa aagcaaaaau ucucuacucu      420

ucauguauga augaaaaagc uauagaaaaa gcugaugcaa aaccuuuacu acacauauua      480

agacauucac cauuucgcug gcccguacua gaaagcaaca uagggccgga aggcguaugg      540

ucagaaagaa aauuuucccu ucuacaaacu uuagcaacau uuagaggaca guacucuaac      600

agcguauuua uaagauuaua cguuucacca gaugacaaag caucaaacga acacauacua      660

aaacuagauc aagcaaccuu aucauuagca guaagagaag acuacuuaga uaacucaaca      720

gaagccaaaa gcuauagaga cgcauuauau aaauucaugg uagacacagc aguuuuguua      780

ggugcaaaua guucgagagc cgaacacgac augaaaucag uacuaagacu ugaaaucaaa      840

auugcugaaa ucaugauacc acacgaaaac agaacuucag aagcuaugua uaauaaaaug      900

aacaucucag aacucucugc aaugauacca caauucgacu gguuagguua cauuaaaaaa      960

gugauagaca cccgauuaua cccucaucuu aaagauauca gcccaagcga aaacgucgua     1020

guacguguac cucaauacuu uaaagaccug uucaggauau uaggaagcga aagaaaaaaa     1080

acgauugcaa auuauuuagu cuggcguaug guuuauucga gaauaccaaa ccuuagcaga     1140

agauuccaau auagauggcu cgaauucagu agagucauac aaggaacaac aacauuacua     1200

ccacaauggg acaaaugugu aaauuucauc gaauccgcau uacccuaugu aguaggaaaa     1260

auguucguag auguauauuu ucaagaagac aaaaaagaaa ugauggaaga acuagucgaa     1320

ggaguaagau gggcauuuau agacaugcuu gaaaaagaaa augaauggau ggaugcaggc     1380

acaaaacgaa aagcaaaaga aaaagcaaga gcaguauuag caaaaguagg auauccugaa     1440

uucauaauga acgacacaca uguaaaugaa gaucuaaaag caauaaaauu uagcgaggcc     1500

gacuacuuug guaacguacu acaaacuaga aaauacuugg cacaaucaga uuuuuuuugg     1560

cuacgaaaag cuguaccaaa aacggaaugg uuuaccaauc cuacaacagu aaacgcuuuc     1620

uauucagcau caacaaauca aauaagguuc ccagccggag aauuacaaaa accauuuuuc     1680

ugggguacug aauaccccag aagucuuucc uauggagcca uuggaguaau aguaggccac     1740

gaauucacac auggcuucga uaacaauggu cgaaaauaug acaaaaaugg aaaucuggau     1800

ccaugguggu ccacagaauc ugaagaaaaa uuuaaagaaa aaacaaaaug uaugauaaau     1860

caauacucua acuauuacug gaaaaaagcu ggauuaaaug uaaaaggaaa aagaacccua     1920

ggagaaaaca uagcagacaa uggaggucuc agggaagcuu uucgagcuua ucgaaaaugg     1980

auuaacgaua gaaggcaagg acuugaagaa ccacuauugc caggaauaac auuuacaaau     2040

aaucaauuau uuuuucuuag cuaugcacac guaagaugua auucauacag accagaagca     2100

gcaagagaac aaguacaaau aggcgcacac aguccaccuc aauucagagu caacggcgca     2160

auaucaaauu ucgaggaauu ucaaaaagca uucaacuguc ccccgaacuc aaccaugaac     2220

cgagguaugg acucaugcag acuaugguaa                                      2250


<210>  7457
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRL__Homo_sapiens__P01236

<400>  7457

Met Asn Ile Lys Gly Ser Pro Trp Lys Gly Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Ser Asn Leu Leu Leu Cys Gln Ser Val Ala Pro Leu Pro Ile Cys 
            20                  25                  30          


Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg Asp Leu Phe Asp 
        35                  40                  45              


Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu Ser Ser Glu Met 
    50                  55                  60                  


Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg Gly Phe Ile Thr 
65                  70                  75                  80  


Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala Thr Pro Glu Asp 
                85                  90                  95      


Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe Leu Ser Leu Ile 
            100                 105                 110         


Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr His Leu Val Thr 
        115                 120                 125             


Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile Leu Ser Lys Ala 
    130                 135                 140                 


Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu Gly Met Glu Leu 
145                 150                 155                 160 


Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn Glu Ile Tyr Pro 
                165                 170                 175     


Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp Glu Glu Ser Arg 
            180                 185                 190         


Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg Arg Asp Ser His 
        195                 200                 205             


Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg Ile Ile His Asn 
    210                 215                 220                 


Asn Asn Cys 
225         


<210>  7458
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRL__Homo_sapiens__AAH15850

<400>  7458
augaacauca aaggaucgcc auggaaaggg ucccuccugc ugcugcuggu gucaaaccug       60

cuccugugcc agagcguggc ccccuugccc aucugucccg gcggggcugc ccgaugccag      120

gugacccuuc gagaccuguu ugaccgcgcc gucguccugu cccacuacau ccauaaccuc      180

uccucagaaa uguucagcga auucgauaaa cgguauaccc auggccgggg guucauuacc      240

aaggccauca acagcugcca cacuucuucc cuugccaccc ccgaagacaa ggagcaagcc      300

caacagauga aucaaaaaga cuuucugagc cugauaguca gcauauugcg auccuggaau      360

gagccucugu aucaucuggu cacggaagua cgugguaugc aagaagcccc ggaggcuauc      420

cuauccaaag cuguagagau ugaggagcaa accaaacggc uucuagaggg cauggagcug      480

auagucagcc agguucaucc ugaaaccaaa gaaaaugaga ucuacccugu cuggucggga      540

cuuccauccc ugcagauggc ugaugaagag ucucgccuuu cugcuuauua uaaccugcuc      600

cacugccuac gcagggauuc acauaaaauc gacaauuauc ucaagcuccu gaagugccga      660

aucauccaca acaacaacug cuaa                                             684


<210>  7459
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRL__Homo_sapiens__AAH15850

<400>  7459
augaacauca agggcagccc cuggaagggg ucccugcucc ugcugcucgu gagcaaccug       60

cugcucugcc aguccgucgc cccgcugccc aucugccccg gcggggccgc gcgcugccag      120

gugacccugc gggaccucuu cgaccgcgcc gugguccuga gccacuacau ccacaaccug      180

uccagcgaga uguucuccga guucgacaag cgguacaccc acggccgcgg guucaucacg      240

aaggccauca acagcugcca caccuccagc cucgccaccc ccgaggacaa ggagcaggcc      300

cagcagauga accagaagga cuuccugucc cugaucguga gcauccuccg guccuggaac      360

gagccgcugu accaccuggu gaccgagguc cgcggcaugc aggaggcgcc cgaggccauc      420

cucagcaagg ccguggagau cgaggagcag acgaagcggc ugcuggaggg cauggagcuc      480

aucguguccc agguccaccc cgagaccaag gagaacgaga ucuaccccgu guggagcggg      540

cugccguccc ugcagauggc cgacgaggag agccgccucu ccgcguacua caaccugcug      600

cacugccucc ggcgcgacag ccacaagauc gacaacuacc ugaagcugcu caagugccgg      660

aucauccaca acaacaacug cuga                                             684


<210>  7460
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRL__Homo_sapiens__AAH15850

<400>  7460
augaacauca agggcucccc cuggaagggc ucccuccucc uccuccucgu cuccaaccuc       60

cuccucugcc aguccgucgc cccccucccc aucugccccg gcggcgccgc ccgcugccag      120

gucacccucc gcgaccucuu cgaccgcgcc gucguccucu cccacuacau ccacaaccuc      180

uccuccgaga uguucuccga guucgacaag cgcuacaccc acggccgcgg cuucaucacc      240

aaggccauca acuccugcca caccuccucc cucgccaccc ccgaggacaa ggagcaggcc      300

cagcagauga accagaagga cuuccucucc cucaucgucu ccauccuccg cuccuggaac      360

gagccccucu accaccucgu caccgagguc cgcggcaugc aggaggcccc cgaggccauc      420

cucuccaagg ccgucgagau cgaggagcag accaagcgcc uccucgaggg cauggagcuc      480

aucgucuccc agguccaccc cgagaccaag gagaacgaga ucuaccccgu cugguccggc      540

cuccccuccc uccagauggc cgacgaggag ucccgccucu ccgccuacua caaccuccuc      600

cacugccucc gccgcgacuc ccacaagauc gacaacuacc ucaagcuccu caagugccgc      660

aucauccaca acaacaacug cuga                                             684


<210>  7461
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRL__Homo_sapiens__AAH15850

<400>  7461
augaacauca agggcagccc cuggaaaggg ucccugcucc uucuguuggu gucuaauuua       60

cugcuaugcc agucagucgc cccucuccca auuuguccgg gaggugcugc aagaugccaa      120

guuacccuga gggaccuuuu cgaucgggcc gugguacuga gucacuacau acauaacuug      180

agcuccgaga uguuuucuga guucgacaag cgcuauacac acggccgagg guuuaucacu      240

aaagcgauua auucguguca uacgucaagc cucgcuaccc ccgaagauaa ggaacaggcc      300

cagcagauga accaaaaaga cuuccugagu cugaucgugu ccauucuccg uucuuggaau      360

gagccuuuau accaccuggu cacagaagug agaggaaugc aggaggcacc agaggccauc      420

cuuagcaagg cuguugaaau agaggaacag acuaagaggu ugcuggaggg cauggagcua      480

aucguguccc agguccaucc cgaaaccaaa gagaacgaaa uuuauccugu guggucaggu      540

cucccaaguc ugcaaauggc agaugaggaa agccggcuuu cugccuacua uaaucuguug      600

cacugccucc gcagagacuc ccacaagauc gauaacuacc ugaaauuacu gaaguguagg      660

auuauccaua auaacaauug cuga                                             684


<210>  7462
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRL__Homo_sapiens__AAH15850

<400>  7462
augaacauca agggcagccc cuggaagggc agccugcugc ugcugcuggu gagcaaccug       60

cugcugugcc agagcguggc cccccugccc aucugccccg gcggcgccgc cagaugccag      120

gugacccuga gagaccuguu cgacagagcc guggugcuga gccacuacau ccacaaccug      180

agcagcgaga uguucagcga guucgacaag agauacaccc acggcagagg cuucaucacc      240

aaggccauca acagcugcca caccagcagc cuggccaccc ccgaggacaa ggagcaggcc      300

cagcagauga accagaagga cuuccugagc cugaucguga gcauccugag aagcuggaac      360

gagccccugu accaccuggu gaccgaggug agaggcaugc aggaggcccc cgaggccauc      420

cugagcaagg ccguggagau cgaggagcag accaagagac ugcuggaggg cauggagcug      480

aucgugagcc aggugcaccc cgagaccaag gagaacgaga ucuaccccgu guggagcggc      540

cugcccagcc ugcagauggc cgacgaggag agcagacuga gcgccuacua caaccugcug      600

cacugccuga gaagagacag ccacaagauc gacaacuacc ugaagcugcu gaagugcaga      660

aucauccaca acaacaacug cuga                                             684


<210>  7463
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRL__Homo_sapiens__AAH15850

<400>  7463
augaacauca agggcagccc cuggaaaggg ucccugcucc ugcuucuggu gucuaaucuc       60

cugcuuugcc agagcgucgc cccucugccg auuugucccg gaggcgcugc cagaugccaa      120

guuacccucc gggaccuguu cgaucgcgcg guggugcugu cccacuacau ccauaaccuc      180

ucuagcgaga uguuuuccga guucgacaag agauauacac acgggcgggg auuuauuacg      240

aaagcuauca auucuuguca uaccagcucc cuggccacac cugaagauaa ggaacaggcc      300

cagcagauga accaaaaaga cuuccuuagc cugauugucu cuauccuccg cuccuggaau      360

gagccccugu accaccuugu gaccgaaguu agaggcaugc aggaggcucc ugaggccauc      420

cugagcaagg cuguggaaau ugaggaacag acaaagcggc uccuggaggg gauggagcug      480

aucgucucuc aggugcaucc cgaaaccaaa gagaacgaaa uuuauccugu uugguccgga      540

cucccgagcc ugcaaauggc cgaugaggaa ucucgccuuu ccgcguacua uaaucugcuc      600

cacugccuga gacgggacag ccacaagauc gauaacuacc uuaaacugcu caagugucgc      660

auuauccaua auaacaauug cuga                                             684


<210>  7464
<211>  684
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       PRL__Homo_sapiens__AAH15850

<400>  7464
augaauauaa aaggaucacc auggaaagga ucacuacuac uacuacuagu aucaaaccua       60

cuacuaugcc aaucaguagc accacuacca aucugcccag gaggagcagc aagaugccaa      120

guaacacuaa gagaccuauu cgacagagca guaguacuau cacacuacau acacaaccua      180

ucaucagaaa uguucucaga auucgacaaa agauacacac acggaagagg auucauaaca      240

aaagcaauaa acucauguca uacaucauca cuagcuacac cagaagacaa agaacaagca      300

caacaaauga accaaaaaga cuuccuauca uuaauaguau caauacuaag aucauggaac      360

gaaccucuau accaucuagu aacagaaguc cgaggaaugc aagaagcacc agaagcaaua      420

cuaucaaaag caguagaaau agaagaacaa acaaaaagac uauuagaagg aauggaauua      480

auaguaucac aaguacaucc agaaacaaaa gaaaacgaaa uauacccagu auggucaggc      540

cuaccuagcc uucaaauggc agacgaagaa ucacgacuau cagcauacua uaaccuacua      600

cacugucuaa gaagagacuc acacaaaaua gacaacuacc uaaaacuauu aaaaugcaga      660

auaauacaca auaacaacug cuaa                                             684


<210>  7465
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  SERPINB5__Homo_sapiens__P36952

<400>  7465

Met Asp Ala Leu Gln Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 
1               5                   10                  15      


Lys Gln Leu Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 
            20                  25                  30          


Ile Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 
        35                  40                  45              


Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys 
    50                  55                  60                  


Asp Val Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu Tyr Val Asp Lys 
                85                  90                  95      


Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser Ser Thr Lys Arg Pro Tyr 
            100                 105                 110         


Ala Lys Glu Leu Glu Thr Val Asp Phe Lys Asp Lys Leu Glu Glu Thr 
        115                 120                 125             


Lys Gly Gln Ile Asn Asn Ser Ile Lys Asp Leu Thr Asp Gly His Phe 
    130                 135                 140                 


Glu Asn Ile Leu Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 
145                 150                 155                 160 


Val Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Ser 
                165                 170                 175     


Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Val Asn Lys Thr Asp Thr 
            180                 185                 190         


Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met Gly Asn 
        195                 200                 205             


Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro Phe Gln Asn Lys 
    210                 215                 220                 


His Leu Ser Met Phe Ile Leu Leu Pro Lys Asp Val Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Glu Lys Ile Glu Lys Gln Leu Asn Ser Glu Ser Leu Ser 
                245                 250                 255     


Gln Trp Thr Asn Pro Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 
            260                 265                 270         


Ile Pro Lys Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 
        275                 280                 285             


Glu Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 
    290                 295                 300                 


Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His 
305                 310                 315                 320 


Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser Ile Glu Val 
                325                 330                 335     


Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu Leu Asn Ala Asp His 
            340                 345                 350         


Pro Phe Ile Tyr Ile Ile Arg His Asn Lys Thr Arg Asn Ile Ile Phe 
        355                 360                 365             


Phe Gly Lys Phe Cys Ser Pro 
    370                 375 


<210>  7466
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7466
auggaugccc ugcaacuagc aaauucggcu uuugccguug aucuguucaa acaacuaugu       60

gaaaaggagc cacugggcaa uguccucuuc ucuccaaucu gucucuccac cucucuguca      120

cuugcucaag ugggugcuaa aggugacacu gcaaaugaaa uuggacaggu ucuucauuuu      180

gaaaauguca aagauguacc cuuuggauuu caaacaguaa caucggaugu aaacaaacuu      240

aguuccuuuu acucacugaa acuaaucaag cggcucuacg uagacaaauc ucugaaucuu      300

ucuacagagu ucaucagcuc uacgaagaga ccguaugcaa aggaauugga aacuguugac      360

uucaaagaua aauuggaaga aacgaaaggu cagaucaaca acucaauuaa ggaucucaca      420

gauggccacu uugagaacau uuuagcugac aacaguguga acgaccagac caaaauccuu      480

gugguuaaug cugccuacuu uguuggcaag uggaugaaga aauuuucuga aucagaaaca      540

aaagaauguc cuuucagagu caacaagaca gacaccaaac cagugcagau gaugaacaug      600

gaggccacgu ucuguauggg aaacauugac aguaucaauu guaagaucau agagcuuccu      660

uuucaaaaua agcaucucag cauguucauc cuacuaccca aggaugugga ggaugagucc      720

acaggcuugg agaagauuga aaaacaacuc aacucagagu cacugucaca guggacuaau      780

cccagcacca uggccaaugc caaggucaaa cucuccauuc caaaauuuaa gguggaaaag      840

augauugauc ccaaggcuug ucuggaaaau cuagggcuga aacauaucuu cagugaagac      900

acaucugauu ucucuggaau gucagagacc aagggagugg cccuaucaaa uguuauccac      960

aaagugugcu uagaaauaac ugaagauggu ggggauucca uagaggugcc aggagcacgg     1020

auccugcagc acaaggauga auugaaugcu gaccaucccu uuauuuacau caucaggcac     1080

aacaaaacuc gaaacauuau uuucuuuggc aaauucuguu cuccuuaa                  1128


<210>  7467
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7467
auggacgccc ugcagcucgc caacagcgcg uucgccgugg accuguucaa gcagcugugc       60

gagaaggagc cccucggcaa cguccuguuc uccccgaucu gccugagcac cucccucagc      120

cuggcccagg ugggggccaa gggcgacacc gccaacgaga ucggccaggu gcugcacuuc      180

gagaacguca aggacgugcc cuucggguuc cagacgguga ccuccgacgu caacaagcuc      240

agcuccuucu acagccugaa gcugaucaag cgccucuacg uggacaaguc ccugaaccug      300

agcaccgagu ucaucuccag caccaagcgg cccuacgcga aggagcucga gacgguggac      360

uucaaggaca agcuggagga gaccaagggg cagaucaaca acuccaucaa ggaccugacc      420

gacggccacu ucgagaacau ccucgccgac aacagcguca acgaccagac caagauccug      480

guggugaacg ccgccuacuu cgucggcaag uggaugaaga aguucuccga gagcgagacg      540

aaggagugcc ccuuccgcgu gaacaagacc gacaccaagc cggugcagau gaugaacaug      600

gaggcgaccu ucugcauggg gaacaucgac uccaucaacu gcaagaucau cgagcugccc      660

uuccagaaca agcaccucag cauguucauc cugcugccca aggacgucga ggacgagucc      720

acgggccucg agaagaucga gaagcagcug aacagcgaga gccuguccca guggaccaac      780

cccagcacca uggccaacgc caaggugaag cucuccaucc cgaaguucaa gguggagaag      840

augaucgacc ccaaggccug ccuggagaac cuggggcuca agcacaucuu cagcgaggac      900

accuccgacu ucagcggcau guccgagacg aagggggucg cccugagcaa cgugauccac      960

aaggugugcc uggagaucac cgaggacggc ggcgacucca ucgagguccc cggggcgcgg     1020

auccuccagc acaaggacga gcugaacgcc gaccaccccu ucaucuacau cauccgccac     1080

aacaagaccc ggaacaucau cuucuucggc aaguucugca gcccguga                  1128


<210>  7468
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7468
auggacgccc uccagcucgc caacuccgcc uucgccgucg accucuucaa gcagcucugc       60

gagaaggagc cccucggcaa cguccucuuc ucccccaucu gccucuccac cucccucucc      120

cucgcccagg ucggcgccaa gggcgacacc gccaacgaga ucggccaggu ccuccacuuc      180

gagaacguca aggacguccc cuucggcuuc cagaccguca ccuccgacgu caacaagcuc      240

uccuccuucu acucccucaa gcucaucaag cgccucuacg ucgacaaguc ccucaaccuc      300

uccaccgagu ucaucuccuc caccaagcgc cccuacgcca aggagcucga gaccgucgac      360

uucaaggaca agcucgagga gaccaagggc cagaucaaca acuccaucaa ggaccucacc      420

gacggccacu ucgagaacau ccucgccgac aacuccguca acgaccagac caagauccuc      480

gucgucaacg ccgccuacuu cgucggcaag uggaugaaga aguucuccga guccgagacc      540

aaggagugcc ccuuccgcgu caacaagacc gacaccaagc ccguccagau gaugaacaug      600

gaggccaccu ucugcauggg caacaucgac uccaucaacu gcaagaucau cgagcucccc      660

uuccagaaca agcaccucuc cauguucauc cuccucccca aggacgucga ggacgagucc      720

accggccucg agaagaucga gaagcagcuc aacuccgagu cccucuccca guggaccaac      780

cccuccacca uggccaacgc caaggucaag cucuccaucc ccaaguucaa ggucgagaag      840

augaucgacc ccaaggccug ccucgagaac cucggccuca agcacaucuu cuccgaggac      900

accuccgacu ucuccggcau guccgagacc aagggcgucg cccucuccaa cgucauccac      960

aaggucugcc ucgagaucac cgaggacggc ggcgacucca ucgagguccc cggcgcccgc     1020

auccuccagc acaaggacga gcucaacgcc gaccaccccu ucaucuacau cauccgccac     1080

aacaagaccc gcaacaucau cuucuucggc aaguucugcu cccccuga                  1128


<210>  7469
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7469
auggacgccc ugcagcucgc uaacagcgca uucgccgugg aucuuuuuaa gcaacugugc       60

gagaaagaac ccuugggcaa ugucuuauuc uccccuaucu gucugucuac cucacuaagu      120

cucgcgcagg uuggggcuaa gggagacaca gccaacgaga uuggucaggu gcugcacuuu      180

gaaaauguaa aagaugugcc auucggcuuu cagacuguca cgagcgacgu gaacaaacuu      240

uccucuuucu acucgcugaa auugauaaag agacucuaug uugauaaguc acugaaucug      300

agcaccgagu uuaucaguuc cacaaaaagg ccguacgcaa aggaacucga gacuguggac      360

uucaaagaua aguuagagga aaccaaaggg caaauuaaca auucuaucaa ggaccugaca      420

gauggacauu uugagaacau ucuugccgac aauagcguca acgaucagac caagaucuug      480

gugguaaaug cugcauauuu cguuggcaaa uggaugaaga aauuuuccga aucagagacu      540

aaggagugcc ccuuccgggu gaacaaaaca gacaccaagc cuguccagau gaugaauaug      600

gaagccacgu uuuguauggg uaacauagau aguaucaauu gcaaaauuau cgagcugcca      660

uuccagaaca agcaccuaag cauguucauu cuccugccca aggacgugga agacgagucu      720

acugggcuug aaaagaucga gaagcaacug aacuccgagu cauugagcca guggaccaau      780

ccuaguacaa uggcuaacgc caaagugaag cucucuauac caaaauuuaa ggucgaaaag      840

augauugauc ccaaagcgug ucuggagaau uuaggacuga agcauaucuu cuccgaagac      900

acuagcgauu uuucgggcau gucugagacc aaaggcguug cacucuccaa cgugauucac      960

aagguaugcc uugaaaucac agaggacggg ggagauucaa ucgaggugcc uggugcccgc     1020

auucugcagc auaaagacga auugaaugcu gaucacccau ucauauacau cauucgacac     1080

aacaagaccc guaauaucau auuuuucggc aaguuuugua guccguga                  1128


<210>  7470
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7470
auggacgccc ugcagcuggc caacagcgcc uucgccgugg accuguucaa gcagcugugc       60

gagaaggagc cccugggcaa cgugcuguuc agccccaucu gccugagcac cagccugagc      120

cuggcccagg ugggcgccaa gggcgacacc gccaacgaga ucggccaggu gcugcacuuc      180

gagaacguga aggacgugcc cuucggcuuc cagaccguga ccagcgacgu gaacaagcug      240

agcagcuucu acagccugaa gcugaucaag agacuguacg uggacaagag ccugaaccug      300

agcaccgagu ucaucagcag caccaagaga cccuacgcca aggagcugga gaccguggac      360

uucaaggaca agcuggagga gaccaagggc cagaucaaca acagcaucaa ggaccugacc      420

gacggccacu ucgagaacau ccuggccgac aacagcguga acgaccagac caagauccug      480

guggugaacg ccgccuacuu cgugggcaag uggaugaaga aguucagcga gagcgagacc      540

aaggagugcc ccuucagagu gaacaagacc gacaccaagc ccgugcagau gaugaacaug      600

gaggccaccu ucugcauggg caacaucgac agcaucaacu gcaagaucau cgagcugccc      660

uuccagaaca agcaccugag cauguucauc cugcugccca aggacgugga ggacgagagc      720

accggccugg agaagaucga gaagcagcug aacagcgaga gccugagcca guggaccaac      780

cccagcacca uggccaacgc caaggugaag cugagcaucc ccaaguucaa gguggagaag      840

augaucgacc ccaaggccug ccuggagaac cugggccuga agcacaucuu cagcgaggac      900

accagcgacu ucagcggcau gagcgagacc aagggcgugg cccugagcaa cgugauccac      960

aaggugugcc uggagaucac cgaggacggc ggcgacagca ucgaggugcc cggcgccaga     1020

auccugcagc acaaggacga gcugaacgcc gaccaccccu ucaucuacau caucagacac     1080

aacaagacca gaaacaucau cuucuucggc aaguucugca gccccuga                  1128


<210>  7471
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7471
auggacgccc ugcagcucgc uaacagcgcc uucgcggugg aucuguuuaa gcaacuuugc       60

gagaaagaac cccugggcaa uguccucuuc uccccuaucu gucugucuac cagccuuucc      120

cuggcucagg uuggggccaa gggagacaca gccaacgaga uuggccaggu gcuccacuuu      180

gaaaauguga aagauguccc guucggguuu cagacgguga ccucugacgu uaacaagcug      240

agcuccuucu acucucugaa acucaucaag agacuguaug uggauaagag ccuuaaucug      300

uccacagagu uuauuagcuc uaccaaacgg cccuacgcua aggaacucga gacagucgac      360

uucaaagaua agcuggagga aaccaaagga caaaucaaca auuccauuaa ggaccuuaca      420

gauggccauu uugagaacau ccuggccgac aauagcguga acgaucagac caagauccuc      480

guugugaaug cugccuauuu cgucgggaaa uggaugaaga aauuuucuga auccgagacg      540

aaggagugcc cuuuccgcgu gaacaaaacc gacacaaagc ccgugcagau gaugaauaug      600

gaagcgaccu uuuguauggg aaacauugau agcaucaauu gcaaaauuau cgagcugccu      660

uuccagaaca agcaccuguc uauguucauu cuccugccca aggacgucga agacgagucc      720

acaggccuug agaaaaucga aaagcaacug aacagcgagu cccucucuca guggaccaau      780

ccuagcacga uggccaacgc uaaaguuaag cuguccauuc cgaaauuuaa gguggaaaag      840

augaucgauc ccaaagccug ucuugagaau cugggccuca agcauaucuu cagcgaagac      900

acaucugauu uuuccgggau gagcgagacc aaaggagugg cucugucuaa cgucauucac      960

aaggugugcc uggaaaucac agaggacggc ggggauagca uugagguucc uggagccaga     1020

auccuccagc auaaagacga acugaaugcg gaucaccccu ucauuuacau cauccggcac     1080

aacaagaccc gcaauauuau cuuuuucggc aaguuuuguu ccccuuga                  1128


<210>  7472
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       SERPINB5__Homo_sapiens__CCDS32839.1

<400>  7472
auggacgcac uucaacucgc aaacucagca uucgccguag accuauucaa acaauuaugc       60

gaaaaagaac cauuaggcaa cguccuauuc ucaccaauau gccuaaguac aagccuaucc      120

cucgcccaag ucggagccaa aggagauaca gcaaaugaaa uaggacaagu acuccacuuc      180

gaaaacguaa aagauguccc auucggauuu caaacaguca caucagacgu caacaaacua      240

ucaucauucu acucacucaa acuaauaaaa agacuauacg ucgauaaauc ccuaaaccua      300

uccacagaau ucauaucauc aacaaaaaga ccauaugcaa aagaacuaga aacuguugau      360

uucaaagaca aauuagaaga aacaaaagga caaauaaaca acucaaucaa agaccuaaca      420

gacggacacu uugaaaacau acucgccgac aauagcguaa augaccaaac aaaaauauua      480

guagucaacg cagcauacuu cguagguaaa uggaugaaaa aauucucaga aucagaaaca      540

aaagaaugcc cauucagagu aaacaaaacc gauacaaaac caguccaaau gaugaacaug      600

gaagcaacau ucuguauggg aaacauagac ucaauaaacu gcaaaauaau agaacuacca      660

uuccaaaaua aacaucucag uauguucaua cuacuaccaa aagacgucga agacgaaucc      720

acaggacuag aaaaaaucga aaaacaacua aacucagaau cacucuccca auggacaaac      780

ccaucaacaa uggcaaaugc aaaaguaaaa cuaucaauac caaaauucaa aguagaaaaa      840

augauagacc caaaagcuug ccuagaaaac cuaggacuaa aacacauuuu cucugaagac      900

acuucagacu ucucaggaau gucagaaaca aaaggaguag cacuaagcaa uguaauucac      960

aaagucugcu uagaaauaac agaagacgga ggagacucaa uagaaguacc uggagccaga     1020

auacuccaac acaaagacga acuaaaugca gaucacccau ucauauacau aauacgacau     1080

aacaaaacua gaaacauaau auucuucggc aaauucuguu caccauaa                  1128


<210>  7473
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__H9N1E7

<400>  7473

Met Val Ile Val Glu Tyr Cys Lys Tyr Gly Asn Leu Ser Asn Tyr Leu 
1               5                   10                  15      


Lys Ser Lys Arg Asp Leu Phe Phe Leu Asn Lys Asp Ala Ala Leu His 
            20                  25                  30          


Met Glu Pro Lys Lys Glu Lys Met Glu Pro Gly Leu Glu Gln Gly Lys 
        35                  40                  45              


Lys Pro Arg Leu Asp Ser Val Thr Ser Ser Glu Ser Phe Ala Ser Ser 
    50                  55                  60                  


Gly Phe Gln Glu Asp Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Ser Asp Gly Phe Tyr Lys Glu Pro Ile Thr Met Glu Asp Leu Ile Ser 
                85                  90                  95      


Tyr Ser Phe Gln Val Ala Arg Gly Met Glu Phe Leu Ser Ser Arg Lys 
            100                 105                 110         


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Asn 
        115                 120                 125             


Asn Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys 
    130                 135                 140                 


Asn Pro Asp Tyr Val Arg Lys Gly Asp Thr Arg Leu Pro Leu Lys Trp 
145                 150                 155                 160 


Met Ala Pro Glu Ser Ile Phe Asp Lys Ile Tyr Ser Thr Lys Ser Asp 
                165                 170                 175     


Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly 
            180                 185                 190         


Ser Pro Tyr Pro Gly Val Gln Met Asp Glu Asp Phe Cys Ser Arg Leu 
        195                 200                 205             


Arg Glu Gly Met Arg Met Arg Ala Pro Glu Tyr Ser Thr Pro Glu Ile 
    210                 215                 220                 


Tyr Gln Ile Met Leu Asp Cys Trp His Arg Asp Pro Lys Glu Arg Pro 
225                 230                 235                 240 


Arg Phe Ala Glu Leu Val Glu Lys Leu Gly Asp Leu Leu Gln Ala Asn 
                245                 250                 255     


Val Gln Gln Asp Gly Lys Asp Tyr Ile Pro Ile Asn Ala Ile Leu Thr 
            260                 265                 270         


Gly Asn Ser Gly Phe Thr Tyr Ser Thr Pro Ala Phe Ser Glu Asp Phe 
        275                 280                 285             


Phe Lys Glu Ser Ile Ser Ala Pro Lys Phe Asn Ser Gly Ser Ser Asp 
    290                 295                 300                 


Asp Val Arg Tyr Val Asn Ala Phe Lys Phe Met Ser Leu Glu Arg Ile 
305                 310                 315                 320 


Lys Thr Phe Glu Glu Leu Leu Pro Asn Ala Thr Ser Met Phe Asp Asp 
                325                 330                 335     


Tyr Gln Gly Asp Ser Ser Thr Leu Leu Ala Ser Pro Met Leu Lys Arg 
            340                 345                 350         


Phe Thr Trp Thr Asp Ser Lys Pro Lys Ala Ser Leu Lys Ile Asp Leu 
        355                 360                 365             


Arg Val Thr Ser Lys Ser Lys Glu Ser Gly Leu Ser Asp Val Ser Arg 
    370                 375                 380                 


Pro Ser Phe Cys His Ser Ser Cys Gly His Val Ser Glu Gly Lys Arg 
385                 390                 395                 400 


Arg Phe Thr Tyr Asp His Ala Glu Leu Glu Arg Lys Ile Ala Cys Cys 
                405                 410                 415     


Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr Ser Thr Pro Pro 
            420                 425                 430         


Ile 
    


<210>  7474
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__AFC77954

<400>  7474
auggugauug uugaauacug caaauaugga aaucucucca acuaccucaa gagcaaacgu       60

gacuuauuuu uucucaacaa ggaugcagca cuacacaugg agccuaagaa agaaaaaaug      120

gagccaggcc uggaacaagg caagaaacca agacuagaua gcgucaccag cagcgaaagc      180

uuugcgagcu ccggcuuuca ggaagauaaa agucugagug auguugagga agaggaggau      240

ucugacgguu ucuacaagga gcccaucacu auggaagauc ugauuucuua caguuuucaa      300

guggccagag gcauggaguu ccugucuucc agaaagugca uucaucggga ccuggcagcg      360

agaaacauuc uuuuaucuga gaacaacgug gugaagauuu gugauuuugg ccuugcccgg      420

gauauuuaua agaaccccga uuaugugaga aaaggagaua cucgacuucc ucugaaaugg      480

auggcuccug aaucuaucuu ugacaaaauc uacagcacca agagcgacgu guggucuuac      540

ggaguauugc ugugggaaau cuucuccuua ggugggucuc cauacccagg aguacaaaug      600

gaugaggacu uuugcagucg ccugagggaa ggcaugagga ugagagcucc ugaguacucu      660

acuccugaaa ucuaucagau caugcuggac ugcuggcaca gagacccaaa agaaaggcca      720

agauuugcag aacuugugga aaaacuaggu gauuugcuuc aagcaaaugu acaacaggau      780

gguaaagacu acaucccaau caaugccaua cugacaggaa auaguggguu uacauacuca      840

acuccugccu ucucugagga cuucuucaag gaaaguauuu cagcuccgaa guuuaauuca      900

ggaagcucug augaugucag auauguaaau gcuuucaagu ucaugagccu ggaaagaauc      960

aaaaccuuug aagaacuuuu accgaaugcc accuccaugu uugaugacua ccagggcgac     1020

agcagcacuc uguuggccuc ucccaugcug aagcgcuuca ccuggacuga cagcaaaccc     1080

aaggccucgc ucaagauuga cuugagagua accaguaaaa guaaggaguc ggggcugucu     1140

gaugucagca ggcccaguuu cugccauucc agcugugggc acgucagcga aggcaagcgc     1200

agguucaccu acgaccacgc ugagcuggaa aggaaaaucg cgugcugcuc cccgccccca     1260

gacuacaacu cggugguccu guacuccacc ccacccaucu ag                        1302


<210>  7475
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7475
auggugaucg ucgaguacug caaguacggc aaccugagca acuaccucaa guccaagcgc       60

gaccuguucu uccugaacaa ggacgccgcc cuccacaugg agcccaagaa ggagaagaug      120

gagcccgggc uggagcaggg caagaagccc cggcuggaca gcgugaccuc cagcgagucc      180

uucgcgagcu ccggguucca ggaggacaag agccucuccg acguggagga ggaggaggac      240

agcgacggcu ucuacaagga gcccaucacc auggaggacc ugaucuccua cagcuuccag      300

gucgcccgcg ggauggaguu ccuguccagc cggaagugca uccaccgcga ccucgccgcc      360

cggaacaucc ugcuguccga gaacaacgug gugaagaucu gcgacuucgg ccucgcccgc      420

gacaucuaca agaaccccga cuacguccgg aagggcgaca cgcgccugcc ccugaagugg      480

auggcgcccg agagcaucuu cgacaagauc uacuccacca agagcgacgu gugguccuac      540

ggggugcucc ugugggagau cuucagccug ggcgggagcc ccuaccccgg cguccagaug      600

gacgaggacu ucugcucccg gcuccgcgag gggaugcgga ugcgcgcccc ggaguacagc      660

acccccgaga ucuaccagau caugcuggac ugcuggcacc gggaccccaa ggagcgcccc      720

cgguucgccg agcuggugga gaagcucggc gaccugcugc aggccaacgu gcagcaggac      780

ggcaaggacu acaucccgau caacgcgauc cucaccggga acuccggcuu cacguacagc      840

acccccgccu ucuccgagga cuucuucaag gagagcaucu ccgcccccaa guucaacagc      900

ggguccagcg acgacguccg cuacgugaac gccuucaagu ucaugucccu ggagcggauc      960

aagaccuucg aggagcugcu ccccaacgcc accagcaugu ucgacgacua ccagggcgac     1020

uccagcacgc ugcuggcguc cccgaugcuc aagcgcuuca ccuggaccga cagcaagccc     1080

aaggccuccc ugaagaucga ccugcgggug accagcaagu ccaaggagag cggccucagc     1140

gacgucuccc gccccagcuu cugccacucc agcugcgggc acguguccga gggcaagcgg     1200

cgcuucacgu acgaccacgc cgagcuggag cgcaagaucg ccugcugcag cccgccgccc     1260

gacuacaacu ccgugguccu guacagcacc ccgcccaucu ga                        1302


<210>  7476
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7476
auggucaucg ucgaguacug caaguacggc aaccucucca acuaccucaa guccaagcgc       60

gaccucuucu uccucaacaa ggacgccgcc cuccacaugg agcccaagaa ggagaagaug      120

gagcccggcc ucgagcaggg caagaagccc cgccucgacu ccgucaccuc cuccgagucc      180

uucgccuccu ccggcuucca ggaggacaag ucccucuccg acgucgagga ggaggaggac      240

uccgacggcu ucuacaagga gcccaucacc auggaggacc ucaucuccua cuccuuccag      300

gucgcccgcg gcauggaguu ccucuccucc cgcaagugca uccaccgcga ccucgccgcc      360

cgcaacaucc uccucuccga gaacaacguc gucaagaucu gcgacuucgg ccucgcccgc      420

gacaucuaca agaaccccga cuacguccgc aagggcgaca cccgccuccc ccucaagugg      480

auggcccccg aguccaucuu cgacaagauc uacuccacca aguccgacgu cugguccuac      540

ggcguccucc ucugggagau cuucucccuc ggcggcuccc ccuaccccgg cguccagaug      600

gacgaggacu ucugcucccg ccuccgcgag ggcaugcgca ugcgcgcccc cgaguacucc      660

acccccgaga ucuaccagau caugcucgac ugcuggcacc gcgaccccaa ggagcgcccc      720

cgcuucgccg agcucgucga gaagcucggc gaccuccucc aggccaacgu ccagcaggac      780

ggcaaggacu acauccccau caacgccauc cucaccggca acuccggcuu caccuacucc      840

acccccgccu ucuccgagga cuucuucaag gaguccaucu ccgcccccaa guucaacucc      900

ggcuccuccg acgacguccg cuacgucaac gccuucaagu ucaugucccu cgagcgcauc      960

aagaccuucg aggagcuccu ccccaacgcc accuccaugu ucgacgacua ccagggcgac     1020

uccuccaccc uccucgccuc ccccaugcuc aagcgcuuca ccuggaccga cuccaagccc     1080

aaggccuccc ucaagaucga ccuccgcguc accuccaagu ccaaggaguc cggccucucc     1140

gacgucuccc gccccuccuu cugccacucc uccugcggcc acgucuccga gggcaagcgc     1200

cgcuucaccu acgaccacgc cgagcucgag cgcaagaucg ccugcugcuc cccccccccc     1260

gacuacaacu ccgucguccu cuacuccacc ccccccaucu ga                        1302


<210>  7477
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7477
auggugaucg ucgaguacug caaguauggc aaccugagca auuaccucaa auccaagaga       60

gaccuuuucu uucugaacaa agaugccgcu uugcacaugg aacccaagaa agagaagaug      120

gaaccugggu uagagcaggg aaagaaacca aggcuggacu cuguuaccuc aagugagagc      180

uucgcauccu cugguuuuca agaagauaag ucgcuaucag acguggagga agaggaagau      240

agcgacggcu ucuauaaaga gccgauuacc auggaggauc ucauaaguua cuccuuucag      300

guagcccggg ggauggaguu ccugucuagc cgcaagugua uccaucgaga ccuugcggcu      360

cguaauauuc uguuguccga aaacaaugug gucaaaaucu gcgauuuugg acucgccaga      420

gacauuuaua agaaccccga uuacgugagg aagggcgaca cucggcugcc ucugaaaugg      480

auggcaccag aaucaaucuu cgauaagaua uauaguacga aaagcgacgu uuggucuuac      540

ggugugcucu uaugggagau cuuuucccuu gggggaucac ccuacccugg cguccagaug      600

gacgaagauu ucuguagccg ccugagagag ggcaugagga ugcgggcccc agaguauagu      660

acccccgaaa uuuaccagau cauguuggac ugcuggcacc gcgauccuaa ggagcgacca      720

agauuugcug aacuggugga gaaacuaggg gaccuccugc aagcaaaugu acagcaggau      780

ggaaaggacu auauuccgau caacgccaua cuuacaggua auucuggcuu cacuuacucc      840

acccccgcuu uuagcgaaga uuucuucaaa gagucgauuu cugccccuaa guuuaacucc      900

gggucaagug acgauguuag guaugugaau gcguucaagu uuaugagccu ggagcggauc      960

aaaacauucg aagaguugcu cccaaacgca accuccaugu uugacgauua ccagggagac     1020

ucuagcacuc uguuagccuc acccaugcug aagcguuuca cauggaccga caguaaaccu     1080

aaggcuuccc ucaaaauuga ucuucgcguc acgagcaagu cuaaggaauc aggccugagu     1140

gacgugagca gaccauccuu uugucauucu ucgugcgguc acgugagcga ggggaaaagg     1200

cgguucacuu augaucaugc cgaauuggag cgaaagaucg cauguugcuc acccccgccu     1260

gacuacaauu ccgucguucu auacaguaca cccccaaucu ga                        1302


<210>  7478
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7478
auggugaucg uggaguacug caaguacggc aaccugagca acuaccugaa gagcaagaga       60

gaccuguucu uccugaacaa ggacgccgcc cugcacaugg agcccaagaa ggagaagaug      120

gagcccggcc uggagcaggg caagaagccc agacuggaca gcgugaccag cagcgagagc      180

uucgccagca gcggcuucca ggaggacaag agccugagcg acguggagga ggaggaggac      240

agcgacggcu ucuacaagga gcccaucacc auggaggacc ugaucagcua cagcuuccag      300

guggccagag gcauggaguu ccugagcagc agaaagugca uccacagaga ccuggccgcc      360

agaaacaucc ugcugagcga gaacaacgug gugaagaucu gcgacuucgg ccuggccaga      420

gacaucuaca agaaccccga cuacgugaga aagggcgaca ccagacugcc ccugaagugg      480

auggcccccg agagcaucuu cgacaagauc uacagcacca agagcgacgu guggagcuac      540

ggcgugcugc ugugggagau cuucagccug ggcggcagcc ccuaccccgg cgugcagaug      600

gacgaggacu ucugcagcag acugagagag ggcaugagaa ugagagcccc cgaguacagc      660

acccccgaga ucuaccagau caugcuggac ugcuggcaca gagaccccaa ggagagaccc      720

agauucgccg agcuggugga gaagcugggc gaccugcugc aggccaacgu gcagcaggac      780

ggcaaggacu acauccccau caacgccauc cugaccggca acagcggcuu caccuacagc      840

acccccgccu ucagcgagga cuucuucaag gagagcauca gcgcccccaa guucaacagc      900

ggcagcagcg acgacgugag auacgugaac gccuucaagu ucaugagccu ggagagaauc      960

aagaccuucg aggagcugcu gcccaacgcc accagcaugu ucgacgacua ccagggcgac     1020

agcagcaccc ugcuggccag ccccaugcug aagagauuca ccuggaccga cagcaagccc     1080

aaggccagcc ugaagaucga ccugagagug accagcaaga gcaaggagag cggccugagc     1140

gacgugagca gacccagcuu cugccacagc agcugcggcc acgugagcga gggcaagaga     1200

agauucaccu acgaccacgc cgagcuggag agaaagaucg ccugcugcag cccccccccc     1260

gacuacaaca gcguggugcu guacagcacc ccccccaucu ga                        1302


<210>  7479
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7479
auggugaucg ucgaguacug caaguauggc aaccugagca auuaccucaa auccaagaga       60

gaccuguucu uucuuaacaa agaugccgcu cugcacaugg aacccaagaa agagaagaug      120

gaaccugggc ucgagcaggg aaagaaaccg cggcuggacu cuguuaccag cuccgaaucu      180

uucgccagcu ccggcuuuca agaggauaag ucucuuagcg acguggagga agaggaagau      240

uccgacgggu ucuauaaaga gcccauuacc auggaggauc ugaucagcua cucuuuucag      300

guggcgcgcg gaauggaguu ccucuccagc agaaagugua uucaucggga ccuggcugcc      360

cgcaauaucc ugcucucuga gaacaauguc gugaaaauuu gcgauuuugg ccuggccaga      420

gacaucuaua agaacccuga uuacguucgg aagggggaca cgcgccuucc ccugaaaugg      480

auggcuccug aauccaucuu cgauaagauu uauagcacca aaucugacgu gugguccuac      540

ggaguccucc ugugggagau cuuuagccuu ggcggcuccc ccuacccugg ggugcagaug      600

gacgaagauu ucuguucuag acugcgggag ggaaugcgca ugagagcccc ggaguauagc      660

acacccgaaa uuuaccagau caugcucgac ugcuggcacc gggauccuaa ggagcgcccc      720

agauuugcug aacugguuga gaaacugggc gaccuccugc aagccaaugu gcagcaggau      780

gggaaggacu auauuccuau caacgcgauu cuuaccggaa auuccggcuu cacauacagc      840

acccccgccu uuucugaaga uuucuucaaa gaguccauca gcgcuccgaa guuuaacucu      900

gggagcuccg acgauguccg guaugugaau gccuucaagu uuaugucucu ggagcgcauc      960

aaaacauucg aagaacuccu gccuaacgcu accagcaugu uugacgauua ccagggagac     1020

uccagcacgc uucuggccuc ucccaugcuc aagagauuca ccuggacaga cuccaaaccu     1080

aaggcgagcc ugaaaauuga ucugcgggug accucuaagu ccaaggaaag cggccucucc     1140

gacgucucua gacccagcuu uugucauucc ucuugcggcc acguuagcga ggggaaacgc     1200

cgguucacau augaucaugc cgaacuggag agaaagaucg cuuguugcuc cccucccccg     1260

gacuacaaua gcguggugcu uuacucuaca cccccuauuu ga                        1302


<210>  7480
<211>  1302
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       sFLT-1__Homo_sapiens__AFC77954

<400>  7480
augguaauag uagaauauug caaauaugga aacuuaucca acuaccuaaa aaguaaaaga       60

gaucuauuuu uccuaaauaa agacgcagcu uuacauaugg aaccaaaaaa agaaaaaaug      120

gaaccaggac uagaacaagg aaaaaaacca agacucgaua guguuacauc auccgaauca      180

uucgcaagcu caggauuuca ggaagauaaa ucauuaagcg acguagaaga agaagaagac      240

uccgacgguu ucuacaaaga accaauaacu auggaagacu uaauaucaua cucauuccaa      300

gucgcgagag gcauggaauu cuuaucaagc cgaaaaugca uacacagaga ccuagcagca      360

agaaacauac uacuuucaga aaauaacgua guaaaaauau gugacuucgg acuagcaaga      420

gauauauaca aaaauccaga cuauguaagg aaaggagaca caagacuacc acuaaaaugg      480

auggcacccg aaagcauauu cgacaaaaua uauucaacaa aaucagaugu auggucauac      540

ggaguacuac uaugggaaau auuuagcuua ggaggcucac cauaccccgg aguacaaaug      600

gacgaagacu uuuguucaag auuaagagaa ggaaugagaa ugagagcacc agaauacagu      660

acuccagaaa uauaccaaau aaugcuagac uguuggcaca gagauccuaa agaacgacca      720

agauuugcag aacuuguaga aaaauuagga gaucuccuac aagcaaaugu ccaacaagac      780

ggaaaagacu acauaccaau aaacgcaauc cuaacaggca acagcggauu cacauacagc      840

acaccagcau ucucagaaga cuucuucaaa gaaucaauau cagcaccaaa auucaacuca      900

ggaaguucag acgacgucag auaugucaac gcauuuaaau ucaugucacu agaacgaaua      960

aaaacauuug aagaguuacu accaaacgca acaucaaugu uugacgauua ccaaggagac     1020

ucaucaacau uacuagccuc accaaugcuc aaaagauuca cauggacaga cucaaaacca     1080

aaagcaucac uaaaaaucga uuuaagaguu acaucaaaau ccaaagaauc aggccuauca     1140

gacguaucaa gaccaagcuu uugccauuca ucaugcggac auguaucaga aggaaaaaga     1200

agauuuaccu acgaccacgc agaacucgaa cgcaaaauag caugcugcuc accaccacca     1260

gacuacaaca guguaguauu auacucaaca ccaccaauau aa                        1302


<210>  7481
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__H9N1E8

<400>  7481

Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys Pro Lys Ala Ser Leu 
1               5                   10                  15      


Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys Glu Ser Gly Leu Ser 
            20                  25                  30          


Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser Cys Gly His Val Ser 
        35                  40                  45              


Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala Glu Leu Glu Arg Lys 
    50                  55                  60                  


Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr 
65                  70                  75                  80  


Ser Thr Pro Pro Ile 
                85  


<210>  7482
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__AFC77955

<400>  7482
augcugaagc gcuucaccug gacugacagc aaacccaagg ccucgcucaa gauugacuug       60

agaguaacca guaaaaguaa ggagucgggg cugucugaug ucagcaggcc caguuucugc      120

cauuccagcu gugggcacgu cagcgaaggc aagcgcaggu ucaccuacga ccacgcugag      180

cuggaaagga aaaucgcgug cugcuccccg cccccagacu acaacucggu gguccuguac      240

uccaccccac ccaucuag                                                    258


<210>  7483
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7483
augcugaagc gcuucaccug gaccgacagc aagcccaagg ccucccucaa gaucgaccug       60

cgggugacga gcaaguccaa ggagagcggc cuguccgacg ucagccgccc guccuucugc      120

cacagcuccu gcgggcacgu gagcgagggc aagcggcgcu ucaccuacga ccacgccgag      180

cucgagcgga agaucgcgug cugcuccccc ccccccgacu acaacagcgu gguccuguac      240

uccaccccgc ccaucuga                                                    258


<210>  7484
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7484
augcucaagc gcuucaccug gaccgacucc aagcccaagg ccucccucaa gaucgaccuc       60

cgcgucaccu ccaaguccaa ggaguccggc cucuccgacg ucucccgccc cuccuucugc      120

cacuccuccu gcggccacgu cuccgagggc aagcgccgcu ucaccuacga ccacgccgag      180

cucgagcgca agaucgccug cugcuccccc ccccccgacu acaacuccgu cguccucuac      240

uccacccccc ccaucuga                                                    258


<210>  7485
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7485
augcugaaga gauucaccug gacagacagc aaacccaagg ccucccucaa aaucgaucuu       60

agggugacuu cuaagucaaa agagaguggc cugagcgacg ucucccggcc uucuuuuugc      120

cacucgucau gugggcaugu uagcgaagga aagcgccgau ucacguacga ucacgcugag      180

uuggaacgua agauugcaug cuguagucca ccgcccgacu auaacuccgu gguauuauac      240

ucuaccccuc caauauga                                                    258


<210>  7486
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7486
augcugaaga gauucaccug gaccgacagc aagcccaagg ccagccugaa gaucgaccug       60

agagugacca gcaagagcaa ggagagcggc cugagcgacg ugagcagacc cagcuucugc      120

cacagcagcu gcggccacgu gagcgagggc aagagaagau ucaccuacga ccacgccgag      180

cuggagagaa agaucgccug cugcagcccc ccccccgacu acaacagcgu ggugcuguac      240

agcacccccc ccaucuga                                                    258


<210>  7487
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7487
augcugaaga gauucaccug gacagacagc aaacccaagg ccucccucaa aaucgaucug       60

cgggugacgu cuaagagcaa agaguccggc cuuucugacg ucagccgccc uuccuuuugc      120

cacucuagcu gugggcaugu uuccgaagga aagagacggu ucaccuacga ucacgcugag      180

cuggaacgca agauugccug cuguagcccg cccccugacu auaacucugu ggugcucuac      240

uccacacccc cuaucuga                                                    258


<210>  7488
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       sFLT-1__Homo_sapiens__AFC77955

<400>  7488
augcuaaaaa gauucacaug gacagacuca aaaccaaaag caucacuaaa aauagaccua       60

agaguaacau caaaaucaaa agaaucagga cuaucagacg uaucaagacc aucauucugc      120

cacucaucau gcggacacgu aucagaagga aaaagaagau ucacauacga ccacgcagaa      180

cuagaaagaa aaauagcaug cugcucacca ccaccagacu acaacucagu aguacuauac      240

ucaacaccac caauauaa                                                    258


<210>  7489
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__L7RSL3

<400>  7489

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile Ser Tyr Ser Phe Gln Val Ala Arg 
        995                 1000                1005            


Gly Met Glu Phe Leu Ser Ser Arg Lys Cys Ile His Arg Asp Leu Ala 
    1010                1015                1020                


Ala Arg Asn Ile Leu Leu Ser Glu Asn Asn Val Val Lys Ile Cys Asp 
1025                1030                1035                1040


Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Pro Asp Tyr Val Arg Lys 
                1045                1050                1055    


Gly Asp Thr Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe 
            1060                1065                1070        


Asp Lys Ile Tyr Ser Thr Lys Ser Asp Val Trp Ser Tyr Gly Val Leu 
        1075                1080                1085            


Leu Trp Glu Ile Phe Ser Leu Gly Gly Ser Pro Tyr Pro Gly Val Gln 
    1090                1095                1100                


Met Asp Glu Asp Phe Cys Ser Arg Leu Arg Glu Gly Met Arg Met Arg 
1105                1110                1115                1120


Ala Pro Glu Tyr Ser Thr Pro Glu Ile Tyr Gln Ile Met Leu Asp Cys 
                1125                1130                1135    


Trp His Arg Asp Pro Lys Glu Arg Pro Arg Phe Ala Glu Leu Val Glu 
            1140                1145                1150        


Lys Leu Gly Asp Leu Leu Gln Ala Asn Val Gln Gln Asp Gly Lys Asp 
        1155                1160                1165            


Tyr Ile Pro Ile Asn Ala Ile Leu Thr Gly Asn Ser Gly Phe Thr Tyr 
    1170                1175                1180                


Ser Thr Pro Ala Phe Ser Glu Asp Phe Phe Lys Glu Ser Ile Ser Ala 
1185                1190                1195                1200


Pro Lys Phe Asn Ser Gly Ser Ser Asp Asp Val Arg Tyr Val Asn Ala 
                1205                1210                1215    


Phe Lys Phe Met Ser Leu Glu Arg Ile Lys Thr Phe Glu Glu Leu Leu 
            1220                1225                1230        


Pro Asn Ala Thr Ser Met Phe Asp Asp Tyr Gln Gly Asp Ser Ser Thr 
        1235                1240                1245            


Leu Leu Ala Ser Pro Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys 
    1250                1255                1260                


Pro Lys Ala Ser Leu Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys 
1265                1270                1275                1280


Glu Ser Gly Leu Ser Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser 
                1285                1290                1295    


Cys Gly His Val Ser Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala 
            1300                1305                1310        


Glu Leu Glu Arg Lys Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn 
        1315                1320                1325            


Ser Val Val Leu Tyr Ser Thr Pro Pro Ile 
    1330                1335            


<210>  7490
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__AGC09589

<400>  7490
auggucagcu acugggacac cgggguccug cugugcgcgc ugcucagcug ucugcuucuc       60

acaggaucua guucagguuc aaaauuaaaa gauccugaac ugaguuuaaa aggcacccag      120

cacaucaugc aagcaggcca gacacugcau cuccaaugca ggggggaagc agcccauaaa      180

uggucuuugc cugaaauggu gaguaaggaa agcgaaaggc ugagcauaac uaaaucugcc      240

uguggaagaa auggcaaaca auucugcagu acuuuaaccu ugaacacagc ucaagcaaac      300

cacacuggcu ucuacagcug caaauaucua gcuguaccua cuucaaagaa gaaggaaaca      360

gaaucugcaa ucuauauauu uauuagugau acagguagac cuuucguaga gauguacagu      420

gaaauccccg aaauuauaca caugacugaa ggaagggagc ucgucauucc cugccggguu      480

acgucaccua acaucacugu uacuuuaaaa aaguuuccac uugacacuuu gaucccugau      540

ggaaaacgca uaaucuggga caguagaaag ggcuucauca uaucaaaugc aacguacaaa      600

gaaauagggc uucugaccug ugaagcaaca gucaaugggc auuuguauaa gacaaacuau      660

cucacacauc gacaaaccaa uacaaucaua gauguccaaa uaagcacacc acgcccaguc      720

aaauuacuua gaggccauac ucuuguccuc aauuguacug cuaccacucc cuugaacacg      780

agaguucaaa ugaccuggag uuacccugau gaaaaaaaua agagagcuuc cguaaggcga      840

cgaauugacc aaagcaauuc ccaugccaac auauucuaca guguucuuac uauugacaaa      900

augcagaaca aagacaaagg acuuuauacu ugucguguaa ggaguggacc aucauucaaa      960

ucuguuaaca ccucagugca uauauaugau aaagcauuca ucacugugaa acaucgaaaa     1020

cagcaggugc uugaaaccgu agcuggcaag cggucuuacc ggcucucuau gaaagugaag     1080

gcauuucccu cgccggaagu uguaugguua aaagaugggu uaccugcgac ugagaaaucu     1140

gcucgcuauu ugacucgugg cuacucguua auuaucaagg acguaacuga agaggaugca     1200

gggaauuaua caaucuugcu gagcauaaaa cagucaaaug uguuuaaaaa ccucacugcc     1260

acucuaauug ucaaugugaa accccagauu uacgaaaagg ccgugucauc guuuccagac     1320

ccggcucucu acccacuggg cagcagacaa auccugacuu guaccgcaua ugguaucccu     1380

caaccuacaa ucaagugguu cuggcacccc uguaaccaua aucauuccga agcaaggugu     1440

gacuuuuguu ccaauaauga agaguccuuu auccuggaug cugacagcaa caugggaaac     1500

agaauugaga gcaucacuca gcgcauggca auaauagaag gaaagaauaa gauggcuagc     1560

accuugguug uggcugacuc uagaauuucu ggaaucuaca uuugcauagc uuccaauaaa     1620

guugggacug ugggaagaaa cauaagcuuu uauaucacag augugccaaa uggguuucau     1680

guuaacuugg aaaaaaugcc gacggaagga gaggaccuga aacugucuug cacaguuaac     1740

aaguucuuau acagagacgu uacuuggauu uuacugcgga caguuaauaa cagaacaaug     1800

cacuacagua uuagcaagca aaaaauggcc aucacuaagg agcacuccau cacucuuaau     1860

cuuaccauca ugaauguuuc ccugcaagau ucaggcaccu augccugcag agccaggaau     1920

guauacacag gggaagaaau ccuccagaag aaagaaauua caaucagaga ucaggaagca     1980

ccauaccucc ugcgaaaccu cagugaucac acaguggcca ucagcaguuc caccacuuua     2040

gacugucaug cuaauggugu ccccgagccu cagaucacuu gguuuaaaaa caaccacaaa     2100

auacaacaag agccuggaau uauuuuagga ccaggaagca gcacgcuguu uauugaaaga     2160

gucacagaag aggaugaagg ugucuaucac ugcaaagcca ccaaccagaa gggcucugug     2220

gaaaguucag cauaccucac uguucaagga accucggaca agucuaaucu ggagcugauc     2280

acucuaacau gcaccugugu ggcugcgacu cucuucuggc uccuauuaac ccucuuuauc     2340

cgaaaaauga aaaggucuuc uucugaaaua aagacugacu accuaucaau uauaauggac     2400

ccagaugaag uuccuuugga ugagcagugu gagcggcucc cuuaugaugc cagcaagugg     2460

gaguuugccc gggagagacu uaaacugggc aaaucacuug gaagaggggc uuuuggaaaa     2520

gugguucaag caucagcauu uggcauuaag aaaucaccua cgugccggac uguggcugug     2580

aaaaugcuga aagagggggc cacggccagc gaguacaaag cucugaugac ugagcuaaaa     2640

aucuugaccc acauuggcca ccaucugaac gugguuaacc ugcugggagc cugcaccaag     2700

caaggagggc cucugauggu gauuguugaa uacugcaaau auggaaaucu cuccaacuac     2760

cucaagagca aacgugacuu auuuuuucuc aacaaggaug cagcacuaca cauggagccu     2820

aagaaagaaa aaauggagcc aggccuggaa caaggcaaga aaccaagacu agauagcguc     2880

accagcagcg aaagcuuugc gagcuccggc uuucaggaag auaaaagucu gagugauguu     2940

gaggaagagg aggauucuga cgguuucuac aaggagccca ucacuaugga agaucugauu     3000

ucuuacaguu uucaaguggc cagaggcaug gaguuccugu cuuccagaaa gugcauucau     3060

cgggaccugg cagcgagaaa cauucuuuua ucugagaaca acguggugaa gauuugugau     3120

uuuggccuug cccgggauau uuauaagaac cccgauuaug ugagaaaagg agauacucga     3180

cuuccucuga aauggauggc uccugaaucu aucuuugaca aaaucuacag caccaagagc     3240

gacguguggu cuuacggagu auugcugugg gaaaucuucu ccuuaggugg gucuccauac     3300

ccaggaguac aaauggauga ggacuuuugc agucgccuga gggaaggcau gaggaugaga     3360

gcuccugagu acucuacucc ugaaaucuau cagaucaugc uggacugcug gcacagagac     3420

ccaaaagaaa ggccaagauu ugcagaacuu guggaaaaac uaggugauuu gcuucaagca     3480

aauguacaac aggaugguaa agacuacauc ccaaucaaug ccauacugac aggaaauagu     3540

ggguuuacau acucaacucc ugccuucucu gaggacuucu ucaaggaaag uauuucagcu     3600

ccgaaguuua auucaggaag cucugaugau gucagauacg uaaaugcuuu caaguucaug     3660

agccuggaaa gaaucaaaac cuuugaagaa cuuuuaccga augccaccuc cauguuugau     3720

gacuaccagg gcgacagcag cacucuguug gccucuccca ugcugaagcg cuucaccugg     3780

acugacagca aacccaaggc cucgcucaag auugacuuga gaguaaccag uaaaaguaag     3840

gagucggggc ugucugaugu cagcaggccc aguuucugcc auuccagcug ugggcacguc     3900

agcgaaggca agcgcagguu caccuacgac cacgcugagc uggaaaggaa aaucgcgugc     3960

ugcuccccgc ccccagacua caacucggug guccuguacu ccaccccacc caucuag        4017


<210>  7491
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7491
auggugagcu acugggacac cggcguccug cucugcgccc ugcuguccug ccuccugcug       60

accgggagcu ccagcggcuc caagcucaag gaccccgagc ugagccugaa ggggacgcag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggggaggc ggcccacaag      180

uggucccugc ccgagauggu gagcaaggag uccgagcggc ugagcaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcagc acccugacgc ugaacaccgc ccaggccaac      300

cacaccgggu ucuacuccug caaguaccuc gcggugccca ccagcaagaa gaaggagacg      360

gaguccgcca ucuacaucuu caucagcgac accggccggc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag gggcgcgagc uggugauccc gugccgggug      480

accagcccca acaucacggu cacccugaag aaguuccccc ucgacacccu gauccccgac      540

ggcaagcgca ucaucuggga cucccggaag ggguucauca ucagcaacgc caccuacaag      600

gagaucggcc ugcucacgug cgaggccacc gugaacggcc accuguacaa gaccaacuac      660

cugacccacc gccagacgaa caccaucauc gacgugcaga ucagcacccc gcggcccguc      720

aagcuccugc gcgggcacac ccuggugcuc aacugcacgg cgaccacgcc ccugaacacc      780

cgggugcaga ugaccugguc cuaccccgac gagaagaaca agcgcgccag cguccggcgc      840

cggaucgacc aguccaacag ccacgccaac aucuucuacu ccgugcugac caucgacaag      900

augcagaaca aggacaaggg ccucuacacg ugccgcgugc ggagcgggcc guccuucaag      960

agcgucaaca ccuccgugca caucuacgac aaggccuuca ucaccgugaa gcaccgcaag     1020

cagcaggucc uggagaccgu ggccggcaag cggagcuacc gccuguccau gaaggugaag     1080

gcguucccca gccccgaggu cguguggcuc aaggacggcc ugcccgccac cgagaagucc     1140

gcccgguacc ugacccgcgg guacagccuc aucaucaagg acgugacgga ggaggacgcc     1200

ggcaacuaca ccauccugcu guccaucaag cagagcaacg ucuucaagaa ccucaccgcc     1260

acccugaucg ugaacgucaa gccgcagauc uacgagaagg cgguguccag cuuccccgac     1320

cccgcccugu acccccucgg gucccgccag auccugaccu gcacggccua cggcaucccg     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacagcga ggcccggugc     1440

gacuucugca gcaacaacga ggaguccuuc auccuggacg ccgacagcaa cauggggaac     1500

cgcaucgagu ccaucaccca gcggauggcg aucaucgagg gcaagaacaa gauggccagc     1560

acccucgugg ucgccgacuc ccgcaucagc ggcaucuaca ucugcaucgc cuccaacaag     1620

guggggacgg ugggccggaa caucagcuuc uacaucaccg acguccccaa cggguuccac     1680

gugaaccugg agaagaugcc gaccgagggc gaggaccuga agcucuccug caccgugaac     1740

aaguuccugu accgcgacgu cacguggauc cugcugcgga ccgugaacaa ccgcaccaug     1800

cacuacagca ucuccaagca gaagauggcc aucaccaagg agcacagcau cacgcucaac     1860

cugaccauca ugaacguguc ccugcaggac agcgggaccu acgcgugccg ggcccgcaac     1920

gucuacaccg gcgaggagau ccuccagaag aaggagauca cgauccggga ccaggaggcc     1980

cccuaccugc ugcgcaaccu cuccgaccac accguggcca ucagcuccag caccacccug     2040

gacugccacg cgaacggcgu gcccgagccc cagaucacgu gguucaagaa caaccacaag     2100

auccagcagg agccggggau cauccugggc cccgggagcu ccacccucuu caucgagcgg     2160

gucaccgagg aggacgaggg cguguaccac ugcaaggcca ccaaccagaa ggggagcgug     2220

gaguccagcg ccuaccugac gguccagggc accuccgaca agagcaaccu ggagcucauc     2280

acccugaccu gcacgugcgu ggccgccacc cuguucuggc uccugcugac ccucuucauc     2340

cgcaagauga agcgguccag cuccgagauc aagaccgacu accugagcau caucauggac     2400

cccgacgagg ugccgcugga cgagcagugc gagcgccucc ccuacgacgc guccaagugg     2460

gaguucgccc gggagcgccu gaagcugggc aagagccucg ggcggggcgc cuucgggaag     2520

gucgugcagg ccuccgccuu cggcaucaag aaguccccca cgugccgcac cguggcgguc     2580

aagaugcuga aggagggcgc caccgccagc gaguacaagg cccugaugac cgagcucaag     2640

auccugacgc acaucgggca ccaccugaac guggugaacc uccugggcgc cugcaccaag     2700

cagggcgggc cccugauggu caucguggag uacugcaagu acgggaaccu cagcaacuac     2760

cugaagucca agcgcgaccu guucuuccuc aacaaggacg cggcccugca cauggagccg     2820

aagaaggaga agauggagcc cggccuggag cagggcaaga agccccggcu cgacagcgug     2880

accuccagcg agagcuucgc cuccagcggg uuccaggagg acaagucccu gagcgacguc     2940

gaggaggagg aggacuccga cggcuucuac aaggagccca ucaccaugga ggaccugauc     3000

agcuacuccu uccagguggc ccgcgggaug gaguuccuca gcucccggaa gugcauccac     3060

cgcgaccugg cggcccggaa cauccugcuc agcgagaaca acguggucaa gaucugcgac     3120

uucggccugg cccgcgacau cuacaagaac ccggacuacg ugcggaaggg ggacacccgc     3180

cugccccuca aguggauggc ccccgagucc aucuucgaca agaucuacag cacgaagucc     3240

gacgugugga gcuacggcgu ccugcugugg gagaucuucu cccucggcgg gagccccuac     3300

ccgggcgugc agauggacga ggacuucugc ucccggcugc gcgaggggau gcggaugcgc     3360

gcccccgagu acagcacccc cgagaucuac cagaucaugc uggacugcug gcaccgggac     3420

cccaaggagc gcccgcgguu cgcggagcuc guggagaagc ugggcgaccu gcuccaggcc     3480

aacguccagc aggacgggaa ggacuacauc cccaucaacg ccauccugac cggcaacucc     3540

ggcuucaccu acagcacgcc cgccuucagc gaggacuucu ucaaggaguc caucagcgcc     3600

cccaaguuca acuccgggag cuccgacgac gugcgcuacg ugaacgcguu caaguucaug     3660

agccuggagc ggaucaagac cuucgaggag cuccugccga acgccaccuc cauguucgac     3720

gacuaccagg gcgacagcuc cacccugcuc gccagcccca ugcugaagcg cuucacgugg     3780

accgacucca agcccaaggc cagccugaag aucgaccucc gggucaccuc caagagcaag     3840

gaguccgggc ugagcgacgu gucccgcccc agcuucugcc acuccagcug cggccacgug     3900

agcgagggga agcggcgcuu caccuacgac cacgccgagc uggagcgcaa gaucgcgugc     3960

ugcuccccgc cgcccgacua caacagcguc gugcucuacu ccacgccgcc caucuga        4017


<210>  7492
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7492
auggucuccu acugggacac cggcguccuc cucugcgccc uccucuccug ccuccuccuc       60

accggcuccu ccuccggcuc caagcucaag gaccccgagc ucucccucaa gggcacccag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggcgaggc cgcccacaag      180

uggucccucc ccgagauggu cuccaaggag uccgagcgcc ucuccaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcucc acccucaccc ucaacaccgc ccaggccaac      300

cacaccggcu ucuacuccug caaguaccuc gccgucccca ccuccaagaa gaaggagacc      360

gaguccgcca ucuacaucuu caucuccgac accggccgcc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag ggccgcgagc ucgucauccc cugccgcguc      480

accuccccca acaucaccgu cacccucaag aaguuccccc ucgacacccu cauccccgac      540

ggcaagcgca ucaucuggga cucccgcaag ggcuucauca ucuccaacgc caccuacaag      600

gagaucggcc uccucaccug cgaggccacc gucaacggcc accucuacaa gaccaacuac      660

cucacccacc gccagaccaa caccaucauc gacguccaga ucuccacccc ccgccccguc      720

aagcuccucc gcggccacac ccucguccuc aacugcaccg ccaccacccc ccucaacacc      780

cgcguccaga ugaccugguc cuaccccgac gagaagaaca agcgcgccuc cguccgccgc      840

cgcaucgacc aguccaacuc ccacgccaac aucuucuacu ccguccucac caucgacaag      900

augcagaaca aggacaaggg ccucuacacc ugccgcgucc gcuccggccc cuccuucaag      960

uccgucaaca ccuccgucca caucuacgac aaggccuuca ucaccgucaa gcaccgcaag     1020

cagcaggucc ucgagaccgu cgccggcaag cgcuccuacc gccucuccau gaaggucaag     1080

gccuuccccu cccccgaggu cgucuggcuc aaggacggcc uccccgccac cgagaagucc     1140

gcccgcuacc ucacccgcgg cuacucccuc aucaucaagg acgucaccga ggaggacgcc     1200

ggcaacuaca ccauccuccu cuccaucaag caguccaacg ucuucaagaa ccucaccgcc     1260

acccucaucg ucaacgucaa gccccagauc uacgagaagg ccgucuccuc cuuccccgac     1320

cccgcccucu acccccucgg cucccgccag auccucaccu gcaccgccua cggcaucccc     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacuccga ggcccgcugc     1440

gacuucugcu ccaacaacga ggaguccuuc auccucgacg ccgacuccaa caugggcaac     1500

cgcaucgagu ccaucaccca gcgcauggcc aucaucgagg gcaagaacaa gauggccucc     1560

acccucgucg ucgccgacuc ccgcaucucc ggcaucuaca ucugcaucgc cuccaacaag     1620

gucggcaccg ucggccgcaa caucuccuuc uacaucaccg acguccccaa cggcuuccac     1680

gucaaccucg agaagaugcc caccgagggc gaggaccuca agcucuccug caccgucaac     1740

aaguuccucu accgcgacgu caccuggauc cuccuccgca ccgucaacaa ccgcaccaug     1800

cacuacucca ucuccaagca gaagauggcc aucaccaagg agcacuccau cacccucaac     1860

cucaccauca ugaacgucuc ccuccaggac uccggcaccu acgccugccg cgcccgcaac     1920

gucuacaccg gcgaggagau ccuccagaag aaggagauca ccauccgcga ccaggaggcc     1980

cccuaccucc uccgcaaccu cuccgaccac accgucgcca ucuccuccuc caccacccuc     2040

gacugccacg ccaacggcgu ccccgagccc cagaucaccu gguucaagaa caaccacaag     2100

auccagcagg agcccggcau cauccucggc cccggcuccu ccacccucuu caucgagcgc     2160

gucaccgagg aggacgaggg cgucuaccac ugcaaggcca ccaaccagaa gggcuccguc     2220

gaguccuccg ccuaccucac cguccagggc accuccgaca aguccaaccu cgagcucauc     2280

acccucaccu gcaccugcgu cgccgccacc cucuucuggc uccuccucac ccucuucauc     2340

cgcaagauga agcgcuccuc cuccgagauc aagaccgacu accucuccau caucauggac     2400

cccgacgagg ucccccucga cgagcagugc gagcgccucc ccuacgacgc cuccaagugg     2460

gaguucgccc gcgagcgccu caagcucggc aagucccucg gccgcggcgc cuucggcaag     2520

gucguccagg ccuccgccuu cggcaucaag aaguccccca ccugccgcac cgucgccguc     2580

aagaugcuca aggagggcgc caccgccucc gaguacaagg cccucaugac cgagcucaag     2640

auccucaccc acaucggcca ccaccucaac gucgucaacc uccucggcgc cugcaccaag     2700

cagggcggcc cccucauggu caucgucgag uacugcaagu acggcaaccu cuccaacuac     2760

cucaagucca agcgcgaccu cuucuuccuc aacaaggacg ccgcccucca cauggagccc     2820

aagaaggaga agauggagcc cggccucgag cagggcaaga agccccgccu cgacuccguc     2880

accuccuccg aguccuucgc cuccuccggc uuccaggagg acaagucccu cuccgacguc     2940

gaggaggagg aggacuccga cggcuucuac aaggagccca ucaccaugga ggaccucauc     3000

uccuacuccu uccaggucgc ccgcggcaug gaguuccucu ccucccgcaa gugcauccac     3060

cgcgaccucg ccgcccgcaa cauccuccuc uccgagaaca acgucgucaa gaucugcgac     3120

uucggccucg cccgcgacau cuacaagaac cccgacuacg uccgcaaggg cgacacccgc     3180

cucccccuca aguggauggc ccccgagucc aucuucgaca agaucuacuc caccaagucc     3240

gacgucuggu ccuacggcgu ccuccucugg gagaucuucu cccucggcgg cucccccuac     3300

cccggcgucc agauggacga ggacuucugc ucccgccucc gcgagggcau gcgcaugcgc     3360

gcccccgagu acuccacccc cgagaucuac cagaucaugc ucgacugcug gcaccgcgac     3420

cccaaggagc gcccccgcuu cgccgagcuc gucgagaagc ucggcgaccu ccuccaggcc     3480

aacguccagc aggacggcaa ggacuacauc cccaucaacg ccauccucac cggcaacucc     3540

ggcuucaccu acuccacccc cgccuucucc gaggacuucu ucaaggaguc caucuccgcc     3600

cccaaguuca acuccggcuc cuccgacgac guccgcuacg ucaacgccuu caaguucaug     3660

ucccucgagc gcaucaagac cuucgaggag cuccucccca acgccaccuc cauguucgac     3720

gacuaccagg gcgacuccuc cacccuccuc gccuccccca ugcucaagcg cuucaccugg     3780

accgacucca agcccaaggc cucccucaag aucgaccucc gcgucaccuc caaguccaag     3840

gaguccggcc ucuccgacgu cucccgcccc uccuucugcc acuccuccug cggccacguc     3900

uccgagggca agcgccgcuu caccuacgac cacgccgagc ucgagcgcaa gaucgccugc     3960

ugcucccccc cccccgacua caacuccguc guccucuacu ccaccccccc caucuga        4017


<210>  7493
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7493
auggugagcu acugggacac cggcguccug cucugcgccc uucuguccug uuuguuacug       60

acagggucuu caaguggaag caagcuaaaa gaucccgagc ucucccugaa ggguacucag      120

cacaucaugc aagcuggcca gacgcuucau cugcagugca gaggggaagc agcccacaaa      180

uggucuuugc cugagauggu uucgaaggaa ucagagaggc ucagcauuac caaaagugcg      240

uguggacgga acggcaagca guucugcucc acacugacuc ugaauaccgc ucaagccaac      300

cauacagguu uuuauucuug uaaguaccuc gcagugccaa ccagcaaaaa gaaagaaacu      360

gaguccgcca uauauaucuu cauuucagac acagggcgcc cguuuguaga gauguacagu      420

gaaauccccg agauuaucca caugaccgaa ggacgagagu uagugauacc uugccguguc      480

acgagcccaa auaucacugu gacccugaag aaauuccccc uugauacauu gauuccugac      540

ggcaagagaa ucauuuggga uucuaggaag ggcuuuauca uauccaacgc uacuuauaaa      600

gagauugggc ugcuaaccug ugaagcaaca guuaauggac aucucuacaa gaccaacuau      660

cugacgcacc ggcagacuaa uacaaucauu gacgugcaga ucucaacccc acgccccguc      720

aaacuucuga gaggucacac uuuggugcuc aacugcacag ccaccacgcc ucugaauacc      780

aggguacaga ugacauggag cuacccagau gagaagaaca aacgggcuag uguucgccga      840

agaaucgacc aaucuaauuc ccaugccaac auuuucuaca gcguguuaac uauagauaag      900

augcagaaua aagacaaggg ccuguauacc uguagggucc ggucggggcc gucuuuuaag      960

uccgugaaca caucagugca caucuacgau aaagcguuca uuacugucaa gcaucguaaa     1020

cagcagguuc ucgaaaccgu ggcaggaaag cgcaguuaua gacuuagcau gaaaguaaag     1080

gccuuucccu ccccugaggu ggucuggcug aaggacggcu ugccagcuac agaaaaaucu     1140

gccagguacc uaacccgggg uuauagccug aucauaaagg augugacuga ggaggacgca     1200

gggaauuaca cgauucuccu gucaaucaaa caaaguaacg uuuucaagaa ccuuacagcu     1260

acccugaucg ugaaugucaa accccagauu uaugaaaagg ccguguccag cuuuccugac     1320

ccagcguugu acccccucgg aucucgacag auccugacuu gcaccgccua cggcauuccg     1380

caaccuacaa uaaagugguu cuggcacccc uguaaccaca aucauucaga ggcacgcugc     1440

gauuuuugca guaacaauga agagagcuuc aucuuagacg cugauuccaa caugggcaau     1500

agaauugaau cuaucaccca gaggauggcc aucauugagg ggaaaaacaa gauggcuucg     1560

acucugguag uugccgacag ccggauaucc ggaaucuaua uuuguaucgc aucaaauaaa     1620

guggguacag ucggccgcaa cauuaguuuc uacaucacgg augugccaaa uggguuucac     1680

gucaaccuag agaagaugcc uaccgaagga gaggaccuca aacugucuug cacugugaau     1740

aaguuccuuu auagagaugu uacauggaua uugcugagga ccgugaacaa ucguacaaug     1800

cauuacagca ucuccaagca gaaaauggcc auuacuaagg aacacucaau cacccucaac     1860

cugacgauua ugaacguaag ccuucaggac ucuggcaccu augcuugucg ggcgcgaaau     1920

gucuacacag gugaggaaau ccugcagaaa aaggagauaa cuauuagaga ucaagaggca     1980

cccuauuugc ucaggaaccu guccgaccau accguggcca ucaguagcuc uacaacuuua     2040

gauugccacg cuaauggggu uccagaaccc cagauuaccu gguuuaaaaa caaucacaag     2100

auccagcaag agccuggcau aauccuggga ccaggcuccu caacgcuauu cauugaacgc     2160

gugacagagg aggacgaagg ggucuaccau uguaaagcca ccaaccagaa gggaagugug     2220

gagagcucgg cauaccucac uguacagggu acauccgaca agucuaaucu ggaacuuauc     2280

accuugacuu gcaccugugu ggccgcuaca cuguuuuggc uccuguuaac gcuguucauu     2340

cggaaaauga agagaagcuc aagugagauc aaaaccgauu aucuuuccau aauuauggac     2400

ccggaugaag uucccuugga cgagcagugc gagaggcucc cuuacgaugc cucuaagugg     2460

gaauuugcac gcgagcgacu gaaacuaggc aagagccugg ggcggggagc guucggcaag     2520

gucgugcagg cuuccgccuu ugguaucaaa aagucaccaa cuugucguac aguggcaguc     2580

aaaaugcuca aggaaggggc caccgcuagc gaguauaaag cccugaugac agaacuuaag     2640

aucuugacuc acauuggcca ucaccugaac guugugaauu uacucggagc augcaccaag     2700

caaggcgggc cccugauggu gaucguagag uacuguaaau auggaaaccu uaguaauuac     2760

cugaagucua aaagagacuu guucuuucuc aacaaggaug cugcccugca cauggagccu     2820

aaaaaggaaa agauggagcc aggucuagaa cagggcaaaa agcccaggcu ggacuccguc     2880

acgagcucgg agucauucgc gucuaguggg uuucaggaag auaaaucccu cagcgacgug     2940

gaggaggaag aggauucuga cggauucuau aaggaaccga uuacaaugga ggaucugaua     3000

agcuacuccu uccaaguugc ccgcggcaug gaguuucuuu caagucggaa augcauccau     3060

agagacuugg cugcaaggaa uauucuguua agcgaaaaca auguggucaa gaucugcgac     3120

uucggucucg cccgagauau uuacaaaaac ccugacuaug ugcgcaaggg ggauacccgg     3180

cugccacuua aguggauggc ucccgagucu aucuuugaca aaauauacuc cacuaaguca     3240

gauguuugga guuauggcgu gcugcuaugg gaaaucuuca gccucggagg cuccccuuac     3300

cccgggguac agauggacga ggauuuuugu ucuagacuga gggaaggaau gcguaugcgc     3360

gccccagagu auucgacccc ugagauuuac cagaucaugu uggacugcug gcaccgggau     3420

cccaaagaaa gaccaagguu cgcagagcug gucgaaaagu uaggcgaccu ccugcaagcg     3480

aacgugcagc aggaugguaa agacuauauu ccgaucaaug ccauacuuac agggaacagc     3540

ggauuuacuu acucaacccc ugcuuucucc gaggacuuuu ucaaggaaag uauuucugcc     3600

cccaaguuua auagcggcuc cucagaugac gugcgauacg ucaacgcauu caaauuuaug     3660

ucucuggagc ggaucaagac auucgaggaa uugcucccaa augcuacgag cauguucgau     3720

gacuaucagg gugauaguuc cacccugcua gccagcccca ugcugaaacg cuuuacuugg     3780

acagacucua agccuaaagc aucacuuaag aucgaucuca gaguuaccuc caagaguaaa     3840

gagagcggcc ugucggacgu gucuaggcca uccuucuguc auagcucaug cgggcacgua     3900

agugaaggaa agcggcgauu uacuuacgau caugccgagu uggaaagaaa aauugcuugu     3960

ugcucucccc cuccggacua uaacuccgug guccuguaca gcacaccacc cauauga        4017


<210>  7494
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7494
auggugagcu acugggacac cggcgugcug cugugcgccc ugcugagcug ccugcugcug       60

accggcagca gcagcggcag caagcugaag gaccccgagc ugagccugaa gggcacccag      120

cacaucaugc aggccggcca gacccugcac cugcagugca gaggcgaggc cgcccacaag      180

uggagccugc ccgagauggu gagcaaggag agcgagagac ugagcaucac caagagcgcc      240

ugcggcagaa acggcaagca guucugcagc acccugaccc ugaacaccgc ccaggccaac      300

cacaccggcu ucuacagcug caaguaccug gccgugccca ccagcaagaa gaaggagacc      360

gagagcgcca ucuacaucuu caucagcgac accggcagac ccuucgugga gauguacagc      420

gagauccccg agaucaucca caugaccgag ggcagagagc uggugauccc cugcagagug      480

accagcccca acaucaccgu gacccugaag aaguuccccc uggacacccu gauccccgac      540

ggcaagagaa ucaucuggga cagcagaaag ggcuucauca ucagcaacgc caccuacaag      600

gagaucggcc ugcugaccug cgaggccacc gugaacggcc accuguacaa gaccaacuac      660

cugacccaca gacagaccaa caccaucauc gacgugcaga ucagcacccc cagacccgug      720

aagcugcuga gaggccacac ccuggugcug aacugcaccg ccaccacccc ccugaacacc      780

agagugcaga ugaccuggag cuaccccgac gagaagaaca agagagccag cgugagaaga      840

agaaucgacc agagcaacag ccacgccaac aucuucuaca gcgugcugac caucgacaag      900

augcagaaca aggacaaggg ccuguacacc ugcagaguga gaagcggccc cagcuucaag      960

agcgugaaca ccagcgugca caucuacgac aaggccuuca ucaccgugaa gcacagaaag     1020

cagcaggugc uggagaccgu ggccggcaag agaagcuaca gacugagcau gaaggugaag     1080

gccuucccca gccccgaggu gguguggcug aaggacggcc ugcccgccac cgagaagagc     1140

gccagauacc ugaccagagg cuacagccug aucaucaagg acgugaccga ggaggacgcc     1200

ggcaacuaca ccauccugcu gagcaucaag cagagcaacg uguucaagaa ccugaccgcc     1260

acccugaucg ugaacgugaa gccccagauc uacgagaagg ccgugagcag cuuccccgac     1320

cccgcccugu acccccuggg cagcagacag auccugaccu gcaccgccua cggcaucccc     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacagcga ggccagaugc     1440

gacuucugca gcaacaacga ggagagcuuc auccuggacg ccgacagcaa caugggcaac     1500

agaaucgaga gcaucaccca gagaauggcc aucaucgagg gcaagaacaa gauggccagc     1560

acccuggugg uggccgacag cagaaucagc ggcaucuaca ucugcaucgc cagcaacaag     1620

gugggcaccg ugggcagaaa caucagcuuc uacaucaccg acgugcccaa cggcuuccac     1680

gugaaccugg agaagaugcc caccgagggc gaggaccuga agcugagcug caccgugaac     1740

aaguuccugu acagagacgu gaccuggauc cugcugagaa ccgugaacaa cagaaccaug     1800

cacuacagca ucagcaagca gaagauggcc aucaccaagg agcacagcau cacccugaac     1860

cugaccauca ugaacgugag ccugcaggac agcggcaccu acgccugcag agccagaaac     1920

guguacaccg gcgaggagau ccugcagaag aaggagauca ccaucagaga ccaggaggcc     1980

cccuaccugc ugagaaaccu gagcgaccac accguggcca ucagcagcag caccacccug     2040

gacugccacg ccaacggcgu gcccgagccc cagaucaccu gguucaagaa caaccacaag     2100

auccagcagg agcccggcau cauccugggc cccggcagca gcacccuguu caucgagaga     2160

gugaccgagg aggacgaggg cguguaccac ugcaaggcca ccaaccagaa gggcagcgug     2220

gagagcagcg ccuaccugac cgugcagggc accagcgaca agagcaaccu ggagcugauc     2280

acccugaccu gcaccugcgu ggccgccacc cuguucuggc ugcugcugac ccuguucauc     2340

agaaagauga agagaagcag cagcgagauc aagaccgacu accugagcau caucauggac     2400

cccgacgagg ugccccugga cgagcagugc gagagacugc ccuacgacgc cagcaagugg     2460

gaguucgcca gagagagacu gaagcugggc aagagccugg gcagaggcgc cuucggcaag     2520

guggugcagg ccagcgccuu cggcaucaag aagagcccca ccugcagaac cguggccgug     2580

aagaugcuga aggagggcgc caccgccagc gaguacaagg cccugaugac cgagcugaag     2640

auccugaccc acaucggcca ccaccugaac guggugaacc ugcugggcgc cugcaccaag     2700

cagggcggcc cccugauggu gaucguggag uacugcaagu acggcaaccu gagcaacuac     2760

cugaagagca agagagaccu guucuuccug aacaaggacg ccgcccugca cauggagccc     2820

aagaaggaga agauggagcc cggccuggag cagggcaaga agcccagacu ggacagcgug     2880

accagcagcg agagcuucgc cagcagcggc uuccaggagg acaagagccu gagcgacgug     2940

gaggaggagg aggacagcga cggcuucuac aaggagccca ucaccaugga ggaccugauc     3000

agcuacagcu uccagguggc cagaggcaug gaguuccuga gcagcagaaa gugcauccac     3060

agagaccugg ccgccagaaa cauccugcug agcgagaaca acguggugaa gaucugcgac     3120

uucggccugg ccagagacau cuacaagaac cccgacuacg ugagaaaggg cgacaccaga     3180

cugccccuga aguggauggc ccccgagagc aucuucgaca agaucuacag caccaagagc     3240

gacgugugga gcuacggcgu gcugcugugg gagaucuuca gccugggcgg cagccccuac     3300

cccggcgugc agauggacga ggacuucugc agcagacuga gagagggcau gagaaugaga     3360

gcccccgagu acagcacccc cgagaucuac cagaucaugc uggacugcug gcacagagac     3420

cccaaggaga gacccagauu cgccgagcug guggagaagc ugggcgaccu gcugcaggcc     3480

aacgugcagc aggacggcaa ggacuacauc cccaucaacg ccauccugac cggcaacagc     3540

ggcuucaccu acagcacccc cgccuucagc gaggacuucu ucaaggagag caucagcgcc     3600

cccaaguuca acagcggcag cagcgacgac gugagauacg ugaacgccuu caaguucaug     3660

agccuggaga gaaucaagac cuucgaggag cugcugccca acgccaccag cauguucgac     3720

gacuaccagg gcgacagcag cacccugcug gccagcccca ugcugaagag auucaccugg     3780

accgacagca agcccaaggc cagccugaag aucgaccuga gagugaccag caagagcaag     3840

gagagcggcc ugagcgacgu gagcagaccc agcuucugcc acagcagcug cggccacgug     3900

agcgagggca agagaagauu caccuacgac cacgccgagc uggagagaaa gaucgccugc     3960

ugcagccccc cccccgacua caacagcgug gugcuguaca gcaccccccc caucuga        4017


<210>  7495
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7495
auggugagcu acugggacac cggcguccug cucugcgccc ugcuuuccug ucugcuccug       60

accgggucua gcuccggauc uaaacuuaag gaucccgagc ugagccucaa gggcacgcag      120

cacaucaugc aagcugggca gacccugcau cugcagugca gaggagaagc cgcgcacaaa      180

uggucccucc cugagauggu uucuaaggaa agcgagcggc uguccauuac aaaaagcgcu      240

uguggccgca acgggaagca guucugcucu acccuuacac ugaauaccgc ccaagccaac      300

cauacaggau uuuauuccug uaaguaccuc gcugugccga ccagcaaaaa gaaagaaacg      360

gagucugcca ucuauauuuu caucuccgac accggcagac ccuuugugga gauguacagc      420

gaaauuccug agaucaucca caugacagaa ggccgggagc uggucauucc cugccgcgug      480

accucuccua auaucacagu uacccuuaag aaauuccccc uggauacgcu cauuccugac      540

gggaagagaa ucauuuggga uucccggaag ggauuuauca uuagcaacgc uacauauaaa      600

gagaucggcc ugcugaccug ugaagccaca gugaaugggc aucucuacaa gaccaacuau      660

cugacccacc gccagacaaa uacgaucauu gacguccaga ucuccacccc gagacccgug      720

aaacuucugc ggggacacac acucguucug aacugcaccg cgacaacccc ucuuaauacg      780

cgcgugcaga ugacaugguc uuaccccgau gagaagaaca aaagagccag cguccggcgc      840

agaauugacc aauccaauag ccaugcuaac aucuucuacu cugugcugac cauugauaag      900

augcagaaua aagacaaggg ccucuauacc ugucgggugc gcuccgggcc uagcuuuaag      960

ucugucaaca caagcguuca caucuacgau aaagccuuca ucaccgugaa gcauagaaaa     1020

caacaggugc uggaaacagu cgcuggaaag cgguccuaua gacugucuau gaaagugaag     1080

gccuuuccca gcccggaggu uguguggcuc aaggacggcc ugccugcgac ggaaaaaucc     1140

gcccgcuacc uuacccgggg cuauagccug auuaucaagg augucacaga ggaggacgcu     1200

gggaauuaca ccauucuccu gucuaucaaa caauccaacg uguucaagaa ccuuacagcc     1260

acccugauug uuaaugugaa accccagauc uaugaaaagg cugucagcuc uuuuccugac     1320

cccgcccucu acccccuggg auccagacag auccugacgu gcaccgccua cggcauuccu     1380

caaccgacaa ucaagugguu cuggcacccc uguaaccaca aucauagcga ggcucgcugc     1440

gauuuuugcu ccaacaauga agagucuuuc auucucgacg cggauagcaa cauggggaau     1500

cggaucgaau ccauuaccca gagaauggcc aucauugagg gcaaaaacaa gauggcuucu     1560

acacuggugg ucgccgacag ccgcaucucc ggaaucuaua uuuguaucgc cagcaauaaa     1620

guggggaccg uuggacggaa cauuucuuuc uacaucacgg augugccuaa uggcuuucac     1680

gucaaccuug agaagaugcc cacagaaggc gaggaccuga aacucuccug caccgugaau     1740

aaguuccugu auagagaugu uacauggauu cugcuucgca ccgugaacaa ucggaccaug     1800

cauuacagca ucucuaagca gaaaauggcu aucacaaagg aacacuccau uacgcucaac     1860

cugaccauca ugaacgucag ccugcaggac ucugggacau augccuguag agcgcgcaau     1920

guguacaccg gagaggaaau ucuccagaaa aaggagauca caauucggga ucaggaggcu     1980

ccuuaucugc uuagaaaccu gagcgaccau accguggcca ucuccagcuc uacgacacuc     2040

gauugccacg ccaauggcgu ucccgaaccg cagaucaccu gguuuaaaaa caaucacaag     2100

auucagcaag agccugggau cauucuggga cccggcucca gcacccuguu caucgaacgg     2160

gucacagagg aggacgaagg gguguaccau uguaaagcua ccaaccagaa gggcuccgug     2220

gagucuagcg ccuaccuuac aguccaggga acguccgaca agucuaaucu cgaacugauu     2280

acccugacau gcaccugugu ggcugccaca cucuuuuggc ugcuucugac ccucuucauc     2340

cgcaaaauga agagaagcuc cucugagauc aaaacggauu aucugagcau uaucauggac     2400

ccugaugaag uuccccugga cgagcagugc gagcggcuuc cuuacgaugc guccaagugg     2460

gaauuugcca gagagcgccu caaacugggc aagagccugg ggcggggagc uuucggcaag     2520

gugguccaag ccucugcuuu ugggauuaaa aaguccccca ccuguagaac aguggccguu     2580

aaaaugcuca aggaaggagc gaccgccagc gaguauaaag cucugaugac agaacuuaag     2640

auccugaccc acauuggcca ucaccucaac guggucaauc ugcugggggc cugcacaaag     2700

cagggcggac cgcuuauggu gaucguugag uacuguaaau auggcaaccu cucuaauuac     2760

cugaagucca aacgcgaccu guucuuucuc aacaaggaug cugcccugca cauggagccu     2820

aaaaaggaaa agauggagcc cgggcuugaa cagggcaaaa agcccagacu ggacagcgug     2880

accucuuccg agagcuucgc cuccagcgga uuucaggaag auaaaucucu cagcgacguc     2940

gaggaggaag aggauuccga cggguucuau aaggaaccua uuacgaugga ggaucugauc     3000

ucuuacagcu uccaaguggc ucggggaaug gaguuucugu ccucucgcaa augcauccau     3060

agagaccuug cggcccggaa uauucugcuc agcgaaaaca auguggucaa gaucugcgac     3120

uucggccugg cucgcgauau uuacaaaaac ccggacuaug uuagaaaggg ggauacacgg     3180

cucccccuga aguggauggc cccugagucc aucuuugaca aaauuuacuc uaccaagagc     3240

gauguguggu ccuauggcgu gcuucugugg gaaaucuuca gccucggagg cucucccuac     3300

ccuggggucc agauggacga ggauuuuugu ucccgccuga gagaaggaau gcggaugcgc     3360

gcccccgagu auagcacccc ugagaucuac cagauuaugc uggacugcug gcacagagau     3420

cccaaagaac ggccgagauu cgcugagcuu guggaaaagc ugggcgaccu ccugcaagcc     3480

aacguucagc aggaugggaa agacuauauc ccuauuaaug cgauccucac aggaaacucu     3540

ggcuuuaccu acuccacgcc cgcuuucagc gaggacuuuu ucaaggaauc cauuucugcc     3600

ccuaaguuua auagcggguc cagcgaugac gugcgcuacg ucaacgccuu caaauuuaug     3660

ucucuggagc ggaucaagac auucgaggaa cuucugccca augcuaccuc cauguucgau     3720

gacuaucagg gcgauagcuc uacacuccug gccagcccga ugcugaaaag auuuaccugg     3780

acagacucca agccuaaagc gucucuuaag aucgaucugc gcgugaccag caaguccaaa     3840

gagucuggac ucagcgacgu uucccggccc agcuucuguc auucuuccug cggccacgug     3900

agcgaaggga agagacgcuu uacguacgau caugcugagc uggaacggaa aauugccugu     3960

ugcuccccuc cucccgacua uaacucuguc gugcucuaca gcacaccccc gaucuga        4017


<210>  7496
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       sFLT-1__Homo_sapiens__AGC09589

<400>  7496
augguuaguu auugggacac aggcguacuu cugugugcuu uacuaucaug uuuauuacua       60

acaggaucau caagcggcuc uaagcuaaaa gauccagaac uaagucugaa gggaacucag      120

cacauaaugc aagcggguca aacucuccac cuccagugcc guggagaagc ugcacauaaa      180

uggaguuugc cagaaauggu cucaaaagaa ucagaacgac uuagcauaac aaaauccgca      240

ugugguagaa augguaaaca auuuugcuca acacucacac uuaauacagc acaagcaaac      300

cacacuggau ucuauagcug caaauaucuu gcuguaccaa cuucaaaaaa aaaagaaaca      360

gaaucagcca uauauaucuu cauaucagac acaggaaggc ccuuuguuga aauguacucu      420

gaaauaccag aaauaauaca uaugacagaa ggucgggaac uugucauccc augcagaguc      480

accuccccaa auaucacagu uacacugaaa aaauuuccac uagauacgcu uauaccagau      540

ggaaaacgua ucaucuggga uucaagaaaa gguuucauca uaucaaaugc cacuuacaaa      600

gaaauaggcu uacucaccug ugaagcaacc guaaauggac acuuauacaa aacuaacuac      660

uuaacacauc gacagacaaa uacgauaaua gauguacaaa uaucaacucc aagaccagua      720

aaauuauuaa gaggacauac gcuaguacua aauuguacug caaccacccc ccucaauaca      780

agaguucaga ugacuugguc auacccagac gaaaaaaaca agagagcuag uguacgcaga      840

agaauugacc aaagcaacuc ucacgcaaac aucuucuacu cuguacuaac uaucgauaaa      900

augcaaaaua aagacaaagg auuauacaca uguagggucc ggucaggacc aucauucaaa      960

aguguaaaua caucaguaca cauuuaugau aaagcauuca uaaccgugaa acaucgaaag     1020

caacaaguau uagagacggu agccggaaaa cguagcuauc gucuaagcau gaaaguaaaa     1080

gcauucccca gcccagaagu cguauggcua aaagauggau uacccgcuac cgaaaaaucc     1140

gcucgcuauc uaacgagagg uuauaguuua auaauaaaag acguaacaga ggaagaugca     1200

gguaauuaua caauccuccu uucaauaaaa cagucaaaug uguucaagaa ucuaacagca     1260

acccucauug uaaacguuaa accucaaaua uacgagaaag ccguauccuc auuuccugau     1320

ccagccuuau auccacuagg aucucgucaa auacugaccu guacggcaua uggaauacca     1380

caaccgacaa uaaaaugguu cuggcaccca uguaaucaca accauuccga agcacguugu     1440

gauuuuugua guaacaauga agaaucguuu aucuuagaug cagacaguaa uauggguaac     1500

agaaucgaau caaucacaca aagaauggcu aucauugaag gaaaaaacaa aauggccuca     1560

acauuaguug uggccgacuc acguauaucc gguaucuaca uuugcauagc gaguaauaaa     1620

gucggaacug ucggccguaa uauaaguuuu uauauaacag augugccaaa uggauuucac     1680

guuaauuuag aaaaaaugcc uacagaaggc gaagaucuca aacuaucuug uacaguaaac     1740

aaauuucuau acagggaugu aacauggaua cuacuacgaa cagugaacaa ucgaaccaug     1800

cauuacagca uaucaaaaca aaaaauggcc auaacaaaag aacauaguau aacauuaaau     1860

cuuacaauca ugaacgucuc gcuacaagau agcgggaccu augcauguag agcacguaac     1920

guguacacag gcgaagaaau acuacaaaaa aaagaaauaa cgauccguga ucaagaggcc     1980

ccauaccuac uccgaaacuu aucagaucac accgucgcaa uuucaucauc cacuacauua     2040

gauugccaug caaacggcgu accagaacca caaaucacau gguuuaaaaa uaaucacaaa     2100

auacaacaag aaccaggaau aauacuaggu cccggcucaa guacuuuauu uauugaacga     2160

guaacagaag aggaugaagg aguguaccac ugcaaagcua caaaucaaaa aggguccguu     2220

gaaaguucgg cauaucucac uguacaagga acuagcgaua aaucuaacuu agaauuaaua     2280

accuuaaccu guaccugcgu agcugccacu cuauuuuggu uacucuugac ccuauucaua     2340

agaaaaauga aaagaucaag uuccgaaaua aaaacugauu accuaaguau aauuauggac     2400

cccgaugaag uaccacuaga ugaacagugc gaacgacucc cuuacgacgc aucaaaaugg     2460

gaauuugcaa gagaaagauu aaaacucgga aaaucuuuag gacguggagc cuuuggaaag     2520

gucguacaag cgagugcuuu cggaauaaaa aagaguccaa ccugccguac aguagcagua     2580

aagaugcuua aagaaggagc aacagcaagc gaauauaagg cucuuaugac agaauuaaaa     2640

auacucaccc auaucggaca ccacuuaaac guaguaaacc uauugggugc gugcacaaaa     2700

caagggggcc cacuaauggu aauagucgaa uacuguaaau augguaauuu aagcaacuac     2760

uuaaaaucaa agagagacuu auucuuuuua aauaaagacg cagcccuuca uauggagcca     2820

aaaaaagaaa aaauggagcc uggauuggaa caagggaaaa aaccucgucu agacaguguu     2880

accaguucgg aaucauucgc aaguagcgga uuccaagaag acaaaucauu gagcgauguu     2940

gaagaagaag aagacucgga cggauuuuau aaggagccaa uuacaaugga agaccuaauc     3000

ucauacucau uucaagucgc aagagguaug gaauucuuau caucucgcaa augcauccac     3060

agagaccuug cugcuagaaa uauuuuacua agcgaaaaua augucgucaa aaucugcgac     3120

uucgguuuag cuagagacau uuauaaaaau cccgacuacg uacgcaaagg agauacaaga     3180

uuaccccuga aauggauggc accugaaucu auauucgaua agauauacuc cacaaaauca     3240

gauguauggu cuuauggugu auuacugugg gaaauauuca gucucggggg uagcccguac     3300

ccaggcguac aaauggacga agauuucugc ucucgccuac gugaaggcau gagaaugcgc     3360

gcucccgaau auaguacccc ugaaauauac caaauaaugu uagauuguug gcaucgagac     3420

cccaaagaaa gacccagguu ugcagaauua guagaaaaac uaggagaccu acuacaagcc     3480

aaugugcaac aagacggaaa agauuauaua cccaucaaug cuauauuaac uggaaauucu     3540

ggauucacuu acuccacccc agccuucuca gaagauuucu ucaaagaauc caucucugca     3600

ccaaaauuca acucaggauc aagcgaugac guccgauacg uaaaugcguu uaaauuuaug     3660

agcuuagagc guauaaaaac auuugaagaa uuacuaccca augccacaag cauguuugac     3720

gacuaccagg gugacucaag uacccuuuua gccucaccaa ugcucaaaag auuuacaugg     3780

acugacucaa aaccuaaagc aucacucaaa auugaucuca gaguuacaag caaaagcaaa     3840

gaaagcggau ugucggacgu aucgcgcccu ucuuuuuguc auucgaguug cggucacgua     3900

ucagaaggua aaagacgauu cacguaugau cacgcugaau uagaaaggaa aauagcaugu     3960

ugcaguccac cgccugacua caauagugua guacuauacu caacaccucc uauuuaa        4017


<210>  7497
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__P17948

<400>  7497

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile Ser Tyr Ser Phe Gln Val Ala Arg 
        995                 1000                1005            


Gly Met Glu Phe Leu Ser Ser Arg Lys Cys Ile His Arg Asp Leu Ala 
    1010                1015                1020                


Ala Arg Asn Ile Leu Leu Ser Glu Asn Asn Val Val Lys Ile Cys Asp 
1025                1030                1035                1040


Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Pro Asp Tyr Val Arg Lys 
                1045                1050                1055    


Gly Asp Thr Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe 
            1060                1065                1070        


Asp Lys Ile Tyr Ser Thr Lys Ser Asp Val Trp Ser Tyr Gly Val Leu 
        1075                1080                1085            


Leu Trp Glu Ile Phe Ser Leu Gly Gly Ser Pro Tyr Pro Gly Val Gln 
    1090                1095                1100                


Met Asp Glu Asp Phe Cys Ser Arg Leu Arg Glu Gly Met Arg Met Arg 
1105                1110                1115                1120


Ala Pro Glu Tyr Ser Thr Pro Glu Ile Tyr Gln Ile Met Leu Asp Cys 
                1125                1130                1135    


Trp His Arg Asp Pro Lys Glu Arg Pro Arg Phe Ala Glu Leu Val Glu 
            1140                1145                1150        


Lys Leu Gly Asp Leu Leu Gln Ala Asn Val Gln Gln Asp Gly Lys Asp 
        1155                1160                1165            


Tyr Ile Pro Ile Asn Ala Ile Leu Thr Gly Asn Ser Gly Phe Thr Tyr 
    1170                1175                1180                


Ser Thr Pro Ala Phe Ser Glu Asp Phe Phe Lys Glu Ser Ile Ser Ala 
1185                1190                1195                1200


Pro Lys Phe Asn Ser Gly Ser Ser Asp Asp Val Arg Tyr Val Asn Ala 
                1205                1210                1215    


Phe Lys Phe Met Ser Leu Glu Arg Ile Lys Thr Phe Glu Glu Leu Leu 
            1220                1225                1230        


Pro Asn Ala Thr Ser Met Phe Asp Asp Tyr Gln Gly Asp Ser Ser Thr 
        1235                1240                1245            


Leu Leu Ala Ser Pro Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys 
    1250                1255                1260                


Pro Lys Ala Ser Leu Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys 
1265                1270                1275                1280


Glu Ser Gly Leu Ser Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser 
                1285                1290                1295    


Cys Gly His Val Ser Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala 
            1300                1305                1310        


Glu Leu Glu Arg Lys Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn 
        1315                1320                1325            


Ser Val Val Leu Tyr Ser Thr Pro Pro Ile 
    1330                1335            


<210>  7498
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  sFLT-1__Homo_sapiens__ABY87530

<400>  7498
auggucagcu acugggacac cgggguccug cugugcgcgc ugcucagcug ucugcuucuc       60

acaggaucua guucagguuc aaaauuaaaa gauccugaac ugaguuuaaa aggcacccag      120

cacaucaugc aagcaggcca gacacugcau cuccaaugca ggggggaagc agcccauaaa      180

uggucuuugc cugaaauggu gaguaaggaa agcgaaaggc ugagcauaac uaaaucugcc      240

uguggaagaa auggcaaaca auucugcagu acuuuaaccu ugaacacagc ucaagcaaac      300

cacacuggcu ucuacagcug caaauaucua gcuguaccua cuucaaagaa gaaggaaaca      360

gaaucugcaa ucuauauauu uauuagugau acagguagac cuuucguaga gauguacagu      420

gaaauccccg aaauuauaca caugacugaa ggaagggagc ucgucauucc cugccggguu      480

acgucaccua acaucacugu uacuuuaaaa aaguuuccac uugacacuuu gaucccugau      540

ggaaaacgca uaaucuggga caguagaaag ggcuucauca uaucaaaugc aacguacaaa      600

gaaauagggc uucugaccug ugaagcaaca gucaaugggc auuuguauaa gacaaacuau      660

cucacacauc gacaaaccaa uacaaucaua gauguccaaa uaagcacacc acgcccaguc      720

aaauuacuua gaggccauac ucuuguccuc aauuguacug cuaccacucc cuugaacacg      780

agaguucaaa ugaccuggag uuacccugau gaaaaaaaua agagagcuuc cguaaggcga      840

cgaauugacc aaagcaauuc ccaugccaac auauucuaca guguucuuac uauugacaaa      900

augcagaaca aagacaaagg acuuuauacu ugucguguaa ggaguggacc aucauucaaa      960

ucuguuaaca ccucagugca uauauaugau aaagcauuca ucacugugaa acaucgaaaa     1020

cagcaggugc uugaaaccgu agcuggcaag cggucuuacc ggcucucuau gaaagugaag     1080

gcauuucccu cgccggaagu uguaugguua aaagaugggu uaccugcgac ugagaaaucu     1140

gcucgcuauu ugacucgugg cuacucguua auuaucaagg acguaacuga agaggaugca     1200

gggaauuaua caaucuugcu gagcauaaaa cagucaaaug uguuuaaaaa ccucacugcc     1260

acucuaauug ucaaugugaa accccagauu uacgaaaagg ccgugucauc guuuccagac     1320

ccggcucucu acccacuggg cagcagacaa auccugacuu guaccgcaua ugguaucccu     1380

caaccuacaa ucaagugguu cuggcacccc uguaaccaua aucauuccga agcaaggugu     1440

gacuuuuguu ccaauaauga agaguccuuu auccuggaug cugacagcaa caugggaaac     1500

agaauugaga gcaucacuca gcgcauggca auaauagaag gaaagaauaa gauggcuagc     1560

accuugguug uggcugacuc uagaauuucu ggaaucuaca uuugcauagc uuccaauaaa     1620

guugggacug ugggaagaaa cauaagcuuu uauaucacag augugccaaa uggguuucau     1680

guuaacuugg aaaaaaugcc gacggaagga gaggaccuga aacugucuug cacaguuaac     1740

aaguucuuau acagagacgu uacuuggauu uuacugcgga caguuaauaa cagaacaaug     1800

cacuacagua uuagcaagca aaaaauggcc aucacuaagg agcacuccau cacucuuaau     1860

cuuaccauca ugaauguuuc ccugcaagau ucaggcaccu augccugcag agccaggaau     1920

guauacacag gggaagaaau ccuccagaag aaagaaauua caaucagaga ucaggaagca     1980

ccauaccucc ugcgaaaccu cagugaucac acaguggcca ucagcaguuc caccacuuua     2040

gacugucaug cuaauggugu ccccgagccu cagaucacuu gguuuaaaaa caaccacaaa     2100

auacaacaag agccuggaau uauuuuagga ccaggaagca gcacgcuguu uauugaaaga     2160

gucacagaag aggaugaagg ugucuaucac ugcaaagcca ccaaccagaa gggcucugug     2220

gaaaguucag cauaccucac uguucaagga accucggaca agucuaaucu ggagcugauc     2280

acucuaacau gcaccugugu ggcugcgacu cucuucuggc uccuauuaac ccucuuuauc     2340

cgaaaaauga aaaggucuuc uucugaaaua aagacugacu accuaucaau uauaauggac     2400

ccagaugaag uuccuuugga ugagcagugu gagcggcucc cuuaugaugc cagcaagugg     2460

gaguuugccc gggagagacu uaaacugggc aaaucacuug gaagaggggc uuuuggaaaa     2520

gugguucaag caucagcauu uggcauuaag aaaucaccua cgugccggac uguggcugug     2580

aaaaugcuga aagagggggc cacggccagc gaguacaaag cucugaugac ugagcuaaaa     2640

aucuugaccc acauuggcca ccaucugaac gugguuaacc ugcugggagc cugcaccaag     2700

caaggagggc cucugauggu gauuguugaa uacugcaaau auggaaaucu cuccaacuac     2760

cucaagagca aacgugacuu auuuuuucuc aacaaggaug cagcacuaca cauggagccu     2820

aagaaagaaa aaauggagcc aggccuggaa caaggcaaga aaccaagacu agauagcguc     2880

accagcagcg aaagcuuugc gagcuccggc uuucaggaag auaaaagucu gagugauguu     2940

gaggaagagg aggauucuga cgguuucuac aaggagccca ucacuaugga agaucugauu     3000

ucuuacaguu uucaaguggc cagaggcaug gaguuccugu cuuccagaaa gugcauucau     3060

cgggaccugg cagcgagaaa cauucuuuua ucugagaaca acguggugaa gauuugugau     3120

uuuggccuug cccgggauau uuauaagaac cccgauuaug ugagaaaagg agauacucga     3180

cuuccucuga aauggauggc uccugaaucu aucuuugaca aaaucuacag caccaagagc     3240

gacguguggu cuuacggagu auugcugugg gaaaucuucu ccuuaggugg gucuccauac     3300

ccaggaguac aaauggauga ggacuuuugc agucgccuga gggaaggcau gaggaugaga     3360

gcuccugagu acucuacucc ugaaaucuau cagaucaugc uggacugcug gcacagagac     3420

ccaaaagaaa ggccaagauu ugcagaacuu guggaaaaac uaggugauuu gcuucaagca     3480

aauguacaac aggaugguaa agacuacauc ccaaucaaug ccauacugac aggaaauagu     3540

ggguuuacau acucaacucc ugccuucucu gaggacuucu ucaaggaaag uauuucagcu     3600

ccgaaguuua auucaggaag cucugaugau gucagauaug uaaaugcuuu caaguucaug     3660

agccuggaaa gaaucaaaac cuuugaagaa cuuuuaccga augccaccuc cauguuugau     3720

gacuaccagg gcgacagcag cacucuguug gccucuccca ugcugaagcg cuucaccugg     3780

acugacagca aacccaaggc cucgcucaag auugacuuga gaguaaccag uaaaaguaag     3840

gagucggggc ugucugaugu cagcaggccc aguuucugcc auuccagcug ugggcacguc     3900

agcgaaggca agcgcagguu caccuacgac cacgcugagc uggaaaggaa aaucgcgugc     3960

ugcuccccgc ccccagacua caacucggug guccuguacu ccaccccacc caucuag        4017


<210>  7499
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7499
auggugagcu acugggacac cggcguccug cucugcgccc ugcuguccug ccuccugcug       60

accgggagcu ccagcggcuc caagcucaag gaccccgagc ugagccugaa ggggacgcag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggggaggc ggcccacaag      180

uggucccugc ccgagauggu gagcaaggag uccgagcggc ugagcaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcagc acccugacgc ugaacaccgc ccaggccaac      300

cacaccgggu ucuacuccug caaguaccuc gcggugccca ccagcaagaa gaaggagacg      360

gaguccgcca ucuacaucuu caucagcgac accggccggc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag gggcgcgagc uggugauccc gugccgggug      480

accagcccca acaucacggu cacccugaag aaguuccccc ucgacacccu gauccccgac      540

ggcaagcgca ucaucuggga cucccggaag ggguucauca ucagcaacgc caccuacaag      600

gagaucggcc ugcucacgug cgaggccacc gugaacggcc accuguacaa gaccaacuac      660

cugacccacc gccagacgaa caccaucauc gacgugcaga ucagcacccc gcggcccguc      720

aagcuccugc gcgggcacac ccuggugcuc aacugcacgg cgaccacgcc ccugaacacc      780

cgggugcaga ugaccugguc cuaccccgac gagaagaaca agcgcgccag cguccggcgc      840

cggaucgacc aguccaacag ccacgccaac aucuucuacu ccgugcugac caucgacaag      900

augcagaaca aggacaaggg ccucuacacg ugccgcgugc ggagcgggcc guccuucaag      960

agcgucaaca ccuccgugca caucuacgac aaggccuuca ucaccgugaa gcaccgcaag     1020

cagcaggucc uggagaccgu ggccggcaag cggagcuacc gccuguccau gaaggugaag     1080

gcguucccca gccccgaggu cguguggcuc aaggacggcc ugcccgccac cgagaagucc     1140

gcccgguacc ugacccgcgg guacagccuc aucaucaagg acgugacgga ggaggacgcc     1200

ggcaacuaca ccauccugcu guccaucaag cagagcaacg ucuucaagaa ccucaccgcc     1260

acccugaucg ugaacgucaa gccgcagauc uacgagaagg cgguguccag cuuccccgac     1320

cccgcccugu acccccucgg gucccgccag auccugaccu gcacggccua cggcaucccg     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacagcga ggcccggugc     1440

gacuucugca gcaacaacga ggaguccuuc auccuggacg ccgacagcaa cauggggaac     1500

cgcaucgagu ccaucaccca gcggauggcg aucaucgagg gcaagaacaa gauggccagc     1560

acccucgugg ucgccgacuc ccgcaucagc ggcaucuaca ucugcaucgc cuccaacaag     1620

guggggacgg ugggccggaa caucagcuuc uacaucaccg acguccccaa cggguuccac     1680

gugaaccugg agaagaugcc gaccgagggc gaggaccuga agcucuccug caccgugaac     1740

aaguuccugu accgcgacgu cacguggauc cugcugcgga ccgugaacaa ccgcaccaug     1800

cacuacagca ucuccaagca gaagauggcc aucaccaagg agcacagcau cacgcucaac     1860

cugaccauca ugaacguguc ccugcaggac agcgggaccu acgcgugccg ggcccgcaac     1920

gucuacaccg gcgaggagau ccuccagaag aaggagauca cgauccggga ccaggaggcc     1980

cccuaccugc ugcgcaaccu cuccgaccac accguggcca ucagcuccag caccacccug     2040

gacugccacg cgaacggcgu gcccgagccc cagaucacgu gguucaagaa caaccacaag     2100

auccagcagg agccggggau cauccugggc cccgggagcu ccacccucuu caucgagcgg     2160

gucaccgagg aggacgaggg cguguaccac ugcaaggcca ccaaccagaa ggggagcgug     2220

gaguccagcg ccuaccugac gguccagggc accuccgaca agagcaaccu ggagcucauc     2280

acccugaccu gcacgugcgu ggccgccacc cuguucuggc uccugcugac ccucuucauc     2340

cgcaagauga agcgguccag cuccgagauc aagaccgacu accugagcau caucauggac     2400

cccgacgagg ugccgcugga cgagcagugc gagcgccucc ccuacgacgc guccaagugg     2460

gaguucgccc gggagcgccu gaagcugggc aagagccucg ggcggggcgc cuucgggaag     2520

gucgugcagg ccuccgccuu cggcaucaag aaguccccca cgugccgcac cguggcgguc     2580

aagaugcuga aggagggcgc caccgccagc gaguacaagg cccugaugac cgagcucaag     2640

auccugacgc acaucgggca ccaccugaac guggugaacc uccugggcgc cugcaccaag     2700

cagggcgggc cccugauggu caucguggag uacugcaagu acgggaaccu cagcaacuac     2760

cugaagucca agcgcgaccu guucuuccuc aacaaggacg cggcccugca cauggagccg     2820

aagaaggaga agauggagcc cggccuggag cagggcaaga agccccggcu cgacagcgug     2880

accuccagcg agagcuucgc cuccagcggg uuccaggagg acaagucccu gagcgacguc     2940

gaggaggagg aggacuccga cggcuucuac aaggagccca ucaccaugga ggaccugauc     3000

agcuacuccu uccagguggc ccgcgggaug gaguuccuca gcucccggaa gugcauccac     3060

cgcgaccugg cggcccggaa cauccugcuc agcgagaaca acguggucaa gaucugcgac     3120

uucggccugg cccgcgacau cuacaagaac ccggacuacg ugcggaaggg ggacacccgc     3180

cugccccuca aguggauggc ccccgagucc aucuucgaca agaucuacag cacgaagucc     3240

gacgugugga gcuacggcgu ccugcugugg gagaucuucu cccucggcgg gagccccuac     3300

ccgggcgugc agauggacga ggacuucugc ucccggcugc gcgaggggau gcggaugcgc     3360

gcccccgagu acagcacccc cgagaucuac cagaucaugc uggacugcug gcaccgggac     3420

cccaaggagc gcccgcgguu cgcggagcuc guggagaagc ugggcgaccu gcuccaggcc     3480

aacguccagc aggacgggaa ggacuacauc cccaucaacg ccauccugac cggcaacucc     3540

ggcuucaccu acagcacgcc cgccuucagc gaggacuucu ucaaggaguc caucagcgcc     3600

cccaaguuca acuccgggag cuccgacgac gugcgcuacg ugaacgcguu caaguucaug     3660

agccuggagc ggaucaagac cuucgaggag cuccugccga acgccaccuc cauguucgac     3720

gacuaccagg gcgacagcuc cacccugcuc gccagcccca ugcugaagcg cuucacgugg     3780

accgacucca agcccaaggc cagccugaag aucgaccucc gggucaccuc caagagcaag     3840

gaguccgggc ugagcgacgu gucccgcccc agcuucugcc acuccagcug cggccacgug     3900

agcgagggga agcggcgcuu caccuacgac cacgccgagc uggagcgcaa gaucgcgugc     3960

ugcuccccgc cgcccgacua caacagcguc gugcucuacu ccacgccgcc caucuga        4017


<210>  7500
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7500
auggucuccu acugggacac cggcguccuc cucugcgccc uccucuccug ccuccuccuc       60

accggcuccu ccuccggcuc caagcucaag gaccccgagc ucucccucaa gggcacccag      120

cacaucaugc aggccggcca gacccuccac cuccagugcc gcggcgaggc cgcccacaag      180

uggucccucc ccgagauggu cuccaaggag uccgagcgcc ucuccaucac caaguccgcc      240

ugcggccgca acggcaagca guucugcucc acccucaccc ucaacaccgc ccaggccaac      300

cacaccggcu ucuacuccug caaguaccuc gccgucccca ccuccaagaa gaaggagacc      360

gaguccgcca ucuacaucuu caucuccgac accggccgcc ccuucgucga gauguacucc      420

gagauccccg agaucaucca caugaccgag ggccgcgagc ucgucauccc cugccgcguc      480

accuccccca acaucaccgu cacccucaag aaguuccccc ucgacacccu cauccccgac      540

ggcaagcgca ucaucuggga cucccgcaag ggcuucauca ucuccaacgc caccuacaag      600

gagaucggcc uccucaccug cgaggccacc gucaacggcc accucuacaa gaccaacuac      660

cucacccacc gccagaccaa caccaucauc gacguccaga ucuccacccc ccgccccguc      720

aagcuccucc gcggccacac ccucguccuc aacugcaccg ccaccacccc ccucaacacc      780

cgcguccaga ugaccugguc cuaccccgac gagaagaaca agcgcgccuc cguccgccgc      840

cgcaucgacc aguccaacuc ccacgccaac aucuucuacu ccguccucac caucgacaag      900

augcagaaca aggacaaggg ccucuacacc ugccgcgucc gcuccggccc cuccuucaag      960

uccgucaaca ccuccgucca caucuacgac aaggccuuca ucaccgucaa gcaccgcaag     1020

cagcaggucc ucgagaccgu cgccggcaag cgcuccuacc gccucuccau gaaggucaag     1080

gccuuccccu cccccgaggu cgucuggcuc aaggacggcc uccccgccac cgagaagucc     1140

gcccgcuacc ucacccgcgg cuacucccuc aucaucaagg acgucaccga ggaggacgcc     1200

ggcaacuaca ccauccuccu cuccaucaag caguccaacg ucuucaagaa ccucaccgcc     1260

acccucaucg ucaacgucaa gccccagauc uacgagaagg ccgucuccuc cuuccccgac     1320

cccgcccucu acccccucgg cucccgccag auccucaccu gcaccgccua cggcaucccc     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacuccga ggcccgcugc     1440

gacuucugcu ccaacaacga ggaguccuuc auccucgacg ccgacuccaa caugggcaac     1500

cgcaucgagu ccaucaccca gcgcauggcc aucaucgagg gcaagaacaa gauggccucc     1560

acccucgucg ucgccgacuc ccgcaucucc ggcaucuaca ucugcaucgc cuccaacaag     1620

gucggcaccg ucggccgcaa caucuccuuc uacaucaccg acguccccaa cggcuuccac     1680

gucaaccucg agaagaugcc caccgagggc gaggaccuca agcucuccug caccgucaac     1740

aaguuccucu accgcgacgu caccuggauc cuccuccgca ccgucaacaa ccgcaccaug     1800

cacuacucca ucuccaagca gaagauggcc aucaccaagg agcacuccau cacccucaac     1860

cucaccauca ugaacgucuc ccuccaggac uccggcaccu acgccugccg cgcccgcaac     1920

gucuacaccg gcgaggagau ccuccagaag aaggagauca ccauccgcga ccaggaggcc     1980

cccuaccucc uccgcaaccu cuccgaccac accgucgcca ucuccuccuc caccacccuc     2040

gacugccacg ccaacggcgu ccccgagccc cagaucaccu gguucaagaa caaccacaag     2100

auccagcagg agcccggcau cauccucggc cccggcuccu ccacccucuu caucgagcgc     2160

gucaccgagg aggacgaggg cgucuaccac ugcaaggcca ccaaccagaa gggcuccguc     2220

gaguccuccg ccuaccucac cguccagggc accuccgaca aguccaaccu cgagcucauc     2280

acccucaccu gcaccugcgu cgccgccacc cucuucuggc uccuccucac ccucuucauc     2340

cgcaagauga agcgcuccuc cuccgagauc aagaccgacu accucuccau caucauggac     2400

cccgacgagg ucccccucga cgagcagugc gagcgccucc ccuacgacgc cuccaagugg     2460

gaguucgccc gcgagcgccu caagcucggc aagucccucg gccgcggcgc cuucggcaag     2520

gucguccagg ccuccgccuu cggcaucaag aaguccccca ccugccgcac cgucgccguc     2580

aagaugcuca aggagggcgc caccgccucc gaguacaagg cccucaugac cgagcucaag     2640

auccucaccc acaucggcca ccaccucaac gucgucaacc uccucggcgc cugcaccaag     2700

cagggcggcc cccucauggu caucgucgag uacugcaagu acggcaaccu cuccaacuac     2760

cucaagucca agcgcgaccu cuucuuccuc aacaaggacg ccgcccucca cauggagccc     2820

aagaaggaga agauggagcc cggccucgag cagggcaaga agccccgccu cgacuccguc     2880

accuccuccg aguccuucgc cuccuccggc uuccaggagg acaagucccu cuccgacguc     2940

gaggaggagg aggacuccga cggcuucuac aaggagccca ucaccaugga ggaccucauc     3000

uccuacuccu uccaggucgc ccgcggcaug gaguuccucu ccucccgcaa gugcauccac     3060

cgcgaccucg ccgcccgcaa cauccuccuc uccgagaaca acgucgucaa gaucugcgac     3120

uucggccucg cccgcgacau cuacaagaac cccgacuacg uccgcaaggg cgacacccgc     3180

cucccccuca aguggauggc ccccgagucc aucuucgaca agaucuacuc caccaagucc     3240

gacgucuggu ccuacggcgu ccuccucugg gagaucuucu cccucggcgg cucccccuac     3300

cccggcgucc agauggacga ggacuucugc ucccgccucc gcgagggcau gcgcaugcgc     3360

gcccccgagu acuccacccc cgagaucuac cagaucaugc ucgacugcug gcaccgcgac     3420

cccaaggagc gcccccgcuu cgccgagcuc gucgagaagc ucggcgaccu ccuccaggcc     3480

aacguccagc aggacggcaa ggacuacauc cccaucaacg ccauccucac cggcaacucc     3540

ggcuucaccu acuccacccc cgccuucucc gaggacuucu ucaaggaguc caucuccgcc     3600

cccaaguuca acuccggcuc cuccgacgac guccgcuacg ucaacgccuu caaguucaug     3660

ucccucgagc gcaucaagac cuucgaggag cuccucccca acgccaccuc cauguucgac     3720

gacuaccagg gcgacuccuc cacccuccuc gccuccccca ugcucaagcg cuucaccugg     3780

accgacucca agcccaaggc cucccucaag aucgaccucc gcgucaccuc caaguccaag     3840

gaguccggcc ucuccgacgu cucccgcccc uccuucugcc acuccuccug cggccacguc     3900

uccgagggca agcgccgcuu caccuacgac cacgccgagc ucgagcgcaa gaucgccugc     3960

ugcucccccc cccccgacua caacuccguc guccucuacu ccaccccccc caucuga        4017


<210>  7501
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7501
auggugagcu acugggacac cggcguccug cucugcgccc uucuguccug uuuguuacug       60

acagggucuu caaguggaag caagcuaaaa gaucccgagc ucucccugaa ggguacucag      120

cacaucaugc aagcuggcca gacgcuucau cugcagugca gaggggaagc agcccacaaa      180

uggucuuugc cugagauggu uucgaaggaa ucagagaggc ucagcauuac caaaagugcg      240

uguggacgga acggcaagca guucugcucc acacugacuc ugaauaccgc ucaagccaac      300

cauacagguu uuuauucuug uaaguaccuc gcagugccaa ccagcaaaaa gaaagaaacu      360

gaguccgcca uauauaucuu cauuucagac acagggcgcc cguuuguaga gauguacagu      420

gaaauccccg agauuaucca caugaccgaa ggacgagagu uagugauacc uugccguguc      480

acgagcccaa auaucacugu gacccugaag aaauuccccc uugauacauu gauuccugac      540

ggcaagagaa ucauuuggga uucuaggaag ggcuuuauca uauccaacgc uacuuauaaa      600

gagauugggc ugcuaaccug ugaagcaaca guuaauggac aucucuacaa gaccaacuau      660

cugacgcacc ggcagacuaa uacaaucauu gacgugcaga ucucaacccc acgccccguc      720

aaacuucuga gaggucacac uuuggugcuc aacugcacag ccaccacgcc ucugaauacc      780

aggguacaga ugacauggag cuacccagau gagaagaaca aacgggcuag uguucgccga      840

agaaucgacc aaucuaauuc ccaugccaac auuuucuaca gcguguuaac uauagauaag      900

augcagaaua aagacaaggg ccuguauacc uguagggucc ggucggggcc gucuuuuaag      960

uccgugaaca caucagugca caucuacgau aaagcguuca uuacugucaa gcaucguaaa     1020

cagcagguuc ucgaaaccgu ggcaggaaag cgcaguuaua gacuuagcau gaaaguaaag     1080

gccuuucccu ccccugaggu ggucuggcug aaggacggcu ugccagcuac agaaaaaucu     1140

gccagguacc uaacccgggg uuauagccug aucauaaagg augugacuga ggaggacgca     1200

gggaauuaca cgauucuccu gucaaucaaa caaaguaacg uuuucaagaa ccuuacagcu     1260

acccugaucg ugaaugucaa accccagauu uaugaaaagg ccguguccag cuuuccugac     1320

ccagcguugu acccccucgg aucucgacag auccugacuu gcaccgccua cggcauuccg     1380

caaccuacaa uaaagugguu cuggcacccc uguaaccaca aucauucaga ggcacgcugc     1440

gauuuuugca guaacaauga agagagcuuc aucuuagacg cugauuccaa caugggcaau     1500

agaauugaau cuaucaccca gaggauggcc aucauugagg ggaaaaacaa gauggcuucg     1560

acucugguag uugccgacag ccggauaucc ggaaucuaua uuuguaucgc aucaaauaaa     1620

guggguacag ucggccgcaa cauuaguuuc uacaucacgg augugccaaa uggguuucac     1680

gucaaccuag agaagaugcc uaccgaagga gaggaccuca aacugucuug cacugugaau     1740

aaguuccuuu auagagaugu uacauggaua uugcugagga ccgugaacaa ucguacaaug     1800

cauuacagca ucuccaagca gaaaauggcc auuacuaagg aacacucaau cacccucaac     1860

cugacgauua ugaacguaag ccuucaggac ucuggcaccu augcuugucg ggcgcgaaau     1920

gucuacacag gugaggaaau ccugcagaaa aaggagauaa cuauuagaga ucaagaggca     1980

cccuauuugc ucaggaaccu guccgaccau accguggcca ucaguagcuc uacaacuuua     2040

gauugccacg cuaauggggu uccagaaccc cagauuaccu gguuuaaaaa caaucacaag     2100

auccagcaag agccuggcau aauccuggga ccaggcuccu caacgcuauu cauugaacgc     2160

gugacagagg aggacgaagg ggucuaccau uguaaagcca ccaaccagaa gggaagugug     2220

gagagcucgg cauaccucac uguacagggu acauccgaca agucuaaucu ggaacuuauc     2280

accuugacuu gcaccugugu ggccgcuaca cuguuuuggc uccuguuaac gcuguucauu     2340

cggaaaauga agagaagcuc aagugagauc aaaaccgauu aucuuuccau aauuauggac     2400

ccggaugaag uucccuugga cgagcagugc gagaggcucc cuuacgaugc cucuaagugg     2460

gaauuugcac gcgagcgacu gaaacuaggc aagagccugg ggcggggagc guucggcaag     2520

gucgugcagg cuuccgccuu ugguaucaaa aagucaccaa cuugucguac aguggcaguc     2580

aaaaugcuca aggaaggggc caccgcuagc gaguauaaag cccugaugac agaacuuaag     2640

aucuugacuc acauuggcca ucaccugaac guugugaauu uacucggagc augcaccaag     2700

caaggcgggc cccugauggu gaucguagag uacuguaaau auggaaaccu uaguaauuac     2760

cugaagucua aaagagacuu guucuuucuc aacaaggaug cugcccugca cauggagccu     2820

aaaaaggaaa agauggagcc aggucuagaa cagggcaaaa agcccaggcu ggacuccguc     2880

acgagcucgg agucauucgc gucuaguggg uuucaggaag auaaaucccu cagcgacgug     2940

gaggaggaag aggauucuga cggauucuau aaggaaccga uuacaaugga ggaucugaua     3000

agcuacuccu uccaaguugc ccgcggcaug gaguuucuuu caagucggaa augcauccau     3060

agagacuugg cugcaaggaa uauucuguua agcgaaaaca auguggucaa gaucugcgac     3120

uucggucucg cccgagauau uuacaaaaac ccugacuaug ugcgcaaggg ggauacccgg     3180

cugccacuua aguggauggc ucccgagucu aucuuugaca aaauauacuc cacuaaguca     3240

gauguuugga guuauggcgu gcugcuaugg gaaaucuuca gccucggagg cuccccuuac     3300

cccgggguac agauggacga ggauuuuugu ucuagacuga gggaaggaau gcguaugcgc     3360

gccccagagu auucgacccc ugagauuuac cagaucaugu uggacugcug gcaccgggau     3420

cccaaagaaa gaccaagguu cgcagagcug gucgaaaagu uaggcgaccu ccugcaagcg     3480

aacgugcagc aggaugguaa agacuauauu ccgaucaaug ccauacuuac agggaacagc     3540

ggauuuacuu acucaacccc ugcuuucucc gaggacuuuu ucaaggaaag uauuucugcc     3600

cccaaguuua auagcggcuc cucagaugac gugcgauacg ucaacgcauu caaauuuaug     3660

ucucuggagc ggaucaagac auucgaggaa uugcucccaa augcuacgag cauguucgau     3720

gacuaucagg gugauaguuc cacccugcua gccagcccca ugcugaaacg cuuuacuugg     3780

acagacucua agccuaaagc aucacuuaag aucgaucuca gaguuaccuc caagaguaaa     3840

gagagcggcc ugucggacgu gucuaggcca uccuucuguc auagcucaug cgggcacgua     3900

agugaaggaa agcggcgauu uacuuacgau caugccgagu uggaaagaaa aauugcuugu     3960

ugcucucccc cuccggacua uaacuccgug guccuguaca gcacaccacc cauauga        4017


<210>  7502
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7502
auggugagcu acugggacac cggcgugcug cugugcgccc ugcugagcug ccugcugcug       60

accggcagca gcagcggcag caagcugaag gaccccgagc ugagccugaa gggcacccag      120

cacaucaugc aggccggcca gacccugcac cugcagugca gaggcgaggc cgcccacaag      180

uggagccugc ccgagauggu gagcaaggag agcgagagac ugagcaucac caagagcgcc      240

ugcggcagaa acggcaagca guucugcagc acccugaccc ugaacaccgc ccaggccaac      300

cacaccggcu ucuacagcug caaguaccug gccgugccca ccagcaagaa gaaggagacc      360

gagagcgcca ucuacaucuu caucagcgac accggcagac ccuucgugga gauguacagc      420

gagauccccg agaucaucca caugaccgag ggcagagagc uggugauccc cugcagagug      480

accagcccca acaucaccgu gacccugaag aaguuccccc uggacacccu gauccccgac      540

ggcaagagaa ucaucuggga cagcagaaag ggcuucauca ucagcaacgc caccuacaag      600

gagaucggcc ugcugaccug cgaggccacc gugaacggcc accuguacaa gaccaacuac      660

cugacccaca gacagaccaa caccaucauc gacgugcaga ucagcacccc cagacccgug      720

aagcugcuga gaggccacac ccuggugcug aacugcaccg ccaccacccc ccugaacacc      780

agagugcaga ugaccuggag cuaccccgac gagaagaaca agagagccag cgugagaaga      840

agaaucgacc agagcaacag ccacgccaac aucuucuaca gcgugcugac caucgacaag      900

augcagaaca aggacaaggg ccuguacacc ugcagaguga gaagcggccc cagcuucaag      960

agcgugaaca ccagcgugca caucuacgac aaggccuuca ucaccgugaa gcacagaaag     1020

cagcaggugc uggagaccgu ggccggcaag agaagcuaca gacugagcau gaaggugaag     1080

gccuucccca gccccgaggu gguguggcug aaggacggcc ugcccgccac cgagaagagc     1140

gccagauacc ugaccagagg cuacagccug aucaucaagg acgugaccga ggaggacgcc     1200

ggcaacuaca ccauccugcu gagcaucaag cagagcaacg uguucaagaa ccugaccgcc     1260

acccugaucg ugaacgugaa gccccagauc uacgagaagg ccgugagcag cuuccccgac     1320

cccgcccugu acccccuggg cagcagacag auccugaccu gcaccgccua cggcaucccc     1380

cagcccacca ucaagugguu cuggcacccc ugcaaccaca accacagcga ggccagaugc     1440

gacuucugca gcaacaacga ggagagcuuc auccuggacg ccgacagcaa caugggcaac     1500

agaaucgaga gcaucaccca gagaauggcc aucaucgagg gcaagaacaa gauggccagc     1560

acccuggugg uggccgacag cagaaucagc ggcaucuaca ucugcaucgc cagcaacaag     1620

gugggcaccg ugggcagaaa caucagcuuc uacaucaccg acgugcccaa cggcuuccac     1680

gugaaccugg agaagaugcc caccgagggc gaggaccuga agcugagcug caccgugaac     1740

aaguuccugu acagagacgu gaccuggauc cugcugagaa ccgugaacaa cagaaccaug     1800

cacuacagca ucagcaagca gaagauggcc aucaccaagg agcacagcau cacccugaac     1860

cugaccauca ugaacgugag ccugcaggac agcggcaccu acgccugcag agccagaaac     1920

guguacaccg gcgaggagau ccugcagaag aaggagauca ccaucagaga ccaggaggcc     1980

cccuaccugc ugagaaaccu gagcgaccac accguggcca ucagcagcag caccacccug     2040

gacugccacg ccaacggcgu gcccgagccc cagaucaccu gguucaagaa caaccacaag     2100

auccagcagg agcccggcau cauccugggc cccggcagca gcacccuguu caucgagaga     2160

gugaccgagg aggacgaggg cguguaccac ugcaaggcca ccaaccagaa gggcagcgug     2220

gagagcagcg ccuaccugac cgugcagggc accagcgaca agagcaaccu ggagcugauc     2280

acccugaccu gcaccugcgu ggccgccacc cuguucuggc ugcugcugac ccuguucauc     2340

agaaagauga agagaagcag cagcgagauc aagaccgacu accugagcau caucauggac     2400

cccgacgagg ugccccugga cgagcagugc gagagacugc ccuacgacgc cagcaagugg     2460

gaguucgcca gagagagacu gaagcugggc aagagccugg gcagaggcgc cuucggcaag     2520

guggugcagg ccagcgccuu cggcaucaag aagagcccca ccugcagaac cguggccgug     2580

aagaugcuga aggagggcgc caccgccagc gaguacaagg cccugaugac cgagcugaag     2640

auccugaccc acaucggcca ccaccugaac guggugaacc ugcugggcgc cugcaccaag     2700

cagggcggcc cccugauggu gaucguggag uacugcaagu acggcaaccu gagcaacuac     2760

cugaagagca agagagaccu guucuuccug aacaaggacg ccgcccugca cauggagccc     2820

aagaaggaga agauggagcc cggccuggag cagggcaaga agcccagacu ggacagcgug     2880

accagcagcg agagcuucgc cagcagcggc uuccaggagg acaagagccu gagcgacgug     2940

gaggaggagg aggacagcga cggcuucuac aaggagccca ucaccaugga ggaccugauc     3000

agcuacagcu uccagguggc cagaggcaug gaguuccuga gcagcagaaa gugcauccac     3060

agagaccugg ccgccagaaa cauccugcug agcgagaaca acguggugaa gaucugcgac     3120

uucggccugg ccagagacau cuacaagaac cccgacuacg ugagaaaggg cgacaccaga     3180

cugccccuga aguggauggc ccccgagagc aucuucgaca agaucuacag caccaagagc     3240

gacgugugga gcuacggcgu gcugcugugg gagaucuuca gccugggcgg cagccccuac     3300

cccggcgugc agauggacga ggacuucugc agcagacuga gagagggcau gagaaugaga     3360

gcccccgagu acagcacccc cgagaucuac cagaucaugc uggacugcug gcacagagac     3420

cccaaggaga gacccagauu cgccgagcug guggagaagc ugggcgaccu gcugcaggcc     3480

aacgugcagc aggacggcaa ggacuacauc cccaucaacg ccauccugac cggcaacagc     3540

ggcuucaccu acagcacccc cgccuucagc gaggacuucu ucaaggagag caucagcgcc     3600

cccaaguuca acagcggcag cagcgacgac gugagauacg ugaacgccuu caaguucaug     3660

agccuggaga gaaucaagac cuucgaggag cugcugccca acgccaccag cauguucgac     3720

gacuaccagg gcgacagcag cacccugcug gccagcccca ugcugaagag auucaccugg     3780

accgacagca agcccaaggc cagccugaag aucgaccuga gagugaccag caagagcaag     3840

gagagcggcc ugagcgacgu gagcagaccc agcuucugcc acagcagcug cggccacgug     3900

agcgagggca agagaagauu caccuacgac cacgccgagc uggagagaaa gaucgccugc     3960

ugcagccccc cccccgacua caacagcgug gugcuguaca gcaccccccc caucuga        4017


<210>  7503
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7503
auggugagcu acugggacac cggcguccug cucugcgccc ugcuuuccug ucugcuccug       60

accgggucua gcuccggauc uaaacuuaag gaucccgagc ugagccucaa gggcacgcag      120

cacaucaugc aagcugggca gacccugcau cugcagugca gaggagaagc cgcgcacaaa      180

uggucccucc cugagauggu uucuaaggaa agcgagcggc uguccauuac aaaaagcgcu      240

uguggccgca acgggaagca guucugcucu acccuuacac ugaauaccgc ccaagccaac      300

cauacaggau uuuauuccug uaaguaccuc gcugugccga ccagcaaaaa gaaagaaacg      360

gagucugcca ucuauauuuu caucuccgac accggcagac ccuuugugga gauguacagc      420

gaaauuccug agaucaucca caugacagaa ggccgggagc uggucauucc cugccgcgug      480

accucuccua auaucacagu uacccuuaag aaauuccccc uggauacgcu cauuccugac      540

gggaagagaa ucauuuggga uucccggaag ggauuuauca uuagcaacgc uacauauaaa      600

gagaucggcc ugcugaccug ugaagccaca gugaaugggc aucucuacaa gaccaacuau      660

cugacccacc gccagacaaa uacgaucauu gacguccaga ucuccacccc gagacccgug      720

aaacuucugc ggggacacac acucguucug aacugcaccg cgacaacccc ucuuaauacg      780

cgcgugcaga ugacaugguc uuaccccgau gagaagaaca aaagagccag cguccggcgc      840

agaauugacc aauccaauag ccaugcuaac aucuucuacu cugugcugac cauugauaag      900

augcagaaua aagacaaggg ccucuauacc ugucgggugc gcuccgggcc uagcuuuaag      960

ucugucaaca caagcguuca caucuacgau aaagccuuca ucaccgugaa gcauagaaaa     1020

caacaggugc uggaaacagu cgcuggaaag cgguccuaua gacugucuau gaaagugaag     1080

gccuuuccca gcccggaggu uguguggcuc aaggacggcc ugccugcgac ggaaaaaucc     1140

gcccgcuacc uuacccgggg cuauagccug auuaucaagg augucacaga ggaggacgcu     1200

gggaauuaca ccauucuccu gucuaucaaa caauccaacg uguucaagaa ccuuacagcc     1260

acccugauug uuaaugugaa accccagauc uaugaaaagg cugucagcuc uuuuccugac     1320

cccgcccucu acccccuggg auccagacag auccugacgu gcaccgccua cggcauuccu     1380

caaccgacaa ucaagugguu cuggcacccc uguaaccaca aucauagcga ggcucgcugc     1440

gauuuuugcu ccaacaauga agagucuuuc auucucgacg cggauagcaa cauggggaau     1500

cggaucgaau ccauuaccca gagaauggcc aucauugagg gcaaaaacaa gauggcuucu     1560

acacuggugg ucgccgacag ccgcaucucc ggaaucuaua uuuguaucgc cagcaauaaa     1620

guggggaccg uuggacggaa cauuucuuuc uacaucacgg augugccuaa uggcuuucac     1680

gucaaccuug agaagaugcc cacagaaggc gaggaccuga aacucuccug caccgugaau     1740

aaguuccugu auagagaugu uacauggauu cugcuucgca ccgugaacaa ucggaccaug     1800

cauuacagca ucucuaagca gaaaauggcu aucacaaagg aacacuccau uacgcucaac     1860

cugaccauca ugaacgucag ccugcaggac ucugggacau augccuguag agcgcgcaau     1920

guguacaccg gagaggaaau ucuccagaaa aaggagauca caauucggga ucaggaggcu     1980

ccuuaucugc uuagaaaccu gagcgaccau accguggcca ucuccagcuc uacgacacuc     2040

gauugccacg ccaauggcgu ucccgaaccg cagaucaccu gguuuaaaaa caaucacaag     2100

auucagcaag agccugggau cauucuggga cccggcucca gcacccuguu caucgaacgg     2160

gucacagagg aggacgaagg gguguaccau uguaaagcua ccaaccagaa gggcuccgug     2220

gagucuagcg ccuaccuuac aguccaggga acguccgaca agucuaaucu cgaacugauu     2280

acccugacau gcaccugugu ggcugccaca cucuuuuggc ugcuucugac ccucuucauc     2340

cgcaaaauga agagaagcuc cucugagauc aaaacggauu aucugagcau uaucauggac     2400

ccugaugaag uuccccugga cgagcagugc gagcggcuuc cuuacgaugc guccaagugg     2460

gaauuugcca gagagcgccu caaacugggc aagagccugg ggcggggagc uuucggcaag     2520

gugguccaag ccucugcuuu ugggauuaaa aaguccccca ccuguagaac aguggccguu     2580

aaaaugcuca aggaaggagc gaccgccagc gaguauaaag cucugaugac agaacuuaag     2640

auccugaccc acauuggcca ucaccucaac guggucaauc ugcugggggc cugcacaaag     2700

cagggcggac cgcuuauggu gaucguugag uacuguaaau auggcaaccu cucuaauuac     2760

cugaagucca aacgcgaccu guucuuucuc aacaaggaug cugcccugca cauggagccu     2820

aaaaaggaaa agauggagcc cgggcuugaa cagggcaaaa agcccagacu ggacagcgug     2880

accucuuccg agagcuucgc cuccagcgga uuucaggaag auaaaucucu cagcgacguc     2940

gaggaggaag aggauuccga cggguucuau aaggaaccua uuacgaugga ggaucugauc     3000

ucuuacagcu uccaaguggc ucggggaaug gaguuucugu ccucucgcaa augcauccau     3060

agagaccuug cggcccggaa uauucugcuc agcgaaaaca auguggucaa gaucugcgac     3120

uucggccugg cucgcgauau uuacaaaaac ccggacuaug uuagaaaggg ggauacacgg     3180

cucccccuga aguggauggc cccugagucc aucuuugaca aaauuuacuc uaccaagagc     3240

gauguguggu ccuauggcgu gcuucugugg gaaaucuuca gccucggagg cucucccuac     3300

ccuggggucc agauggacga ggauuuuugu ucccgccuga gagaaggaau gcggaugcgc     3360

gcccccgagu auagcacccc ugagaucuac cagauuaugc uggacugcug gcacagagau     3420

cccaaagaac ggccgagauu cgcugagcuu guggaaaagc ugggcgaccu ccugcaagcc     3480

aacguucagc aggaugggaa agacuauauc ccuauuaaug cgauccucac aggaaacucu     3540

ggcuuuaccu acuccacgcc cgcuuucagc gaggacuuuu ucaaggaauc cauuucugcc     3600

ccuaaguuua auagcggguc cagcgaugac gugcgcuacg ucaacgccuu caaauuuaug     3660

ucucuggagc ggaucaagac auucgaggaa cuucugccca augcuaccuc cauguucgau     3720

gacuaucagg gcgauagcuc uacacuccug gccagcccga ugcugaaaag auuuaccugg     3780

acagacucca agccuaaagc gucucuuaag aucgaucugc gcgugaccag caaguccaaa     3840

gagucuggac ucagcgacgu uucccggccc agcuucuguc auucuuccug cggccacgug     3900

agcgaaggga agagacgcuu uacguacgau caugcugagc uggaacggaa aauugccugu     3960

ugcuccccuc cucccgacua uaacucuguc gugcucuaca gcacaccccc gaucuga        4017


<210>  7504
<211>  4017
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       sFLT-1__Homo_sapiens__ABY87530

<400>  7504
augguuagcu acugggauac uggagugcua uuaugugcac uauuaaguug cuuauuacuu       60

accgguucaa guucuggaag uaaacuuaag gacccagaau uaagucuuaa aggcacucaa      120

cauaucaugc aagcuggaca aacacuucau cuccaaugcc gaggagaagc agcacauaaa      180

uggucucuac cagaaauggu uaguaaagaa uccgaacgac uuucuauuac aaaauccgca      240

ugcggccgaa acgggaaaca auuuuguucc acacuaacac uaaauacagc ucaggcgaac      300

cauacuggcu uuuacagcug caaauaucuu gccgugccaa cgaguaaaaa gaaagaaacu      360

gaaucagcaa uuuacaucuu cauuucggac acagguagac cauucguaga aauguauagu      420

gaaauaccag aaaucaucca uaugacugaa ggcagagaac uuguuauacc augcagaguu      480

acuagcccua acauaacagu cacacuuaag aaauucccac uagacacacu cauuccugac      540

ggaaaacgga uaauuuggga uagucguaaa ggauucauaa uauccaacgc aacuuauaag      600

gaaauaggau uacuaacuug cgaagccacc guaaaugguc auuuauauaa aaccaauuac      660

uuaacccacc gucaaacaaa cacaauuaua gauguucaaa uaaguacacc gagaccaguc      720

aaacugcucc gaggacacac acuaguucua aacuguaccg caaccacccc ucuaaacacc      780

agagugcaaa ugacaugguc auauccugac gaaaaaaaca aacgcgccuc aguacgacgc      840

agaauugacc aaaguaauuc ccaugccaac aucuuuuauu caguguugac aaucgauaag      900

augcaaaaca aagauaaagg acuuuacaca uguagaguac gcucaggucc caguuuuaaa      960

ucaguaaaua caagugucca uauauacgau aaagccuuua uaacaguaaa acauagaaaa     1020

caacaaguuu uagaaacagu agcuggaaaa cgauccuaua ggcuaucaau gaaaguuaaa     1080

gcuuuuccuu caccugaagu uguuugguua aaggacggac ucccugccac agaaaaaagc     1140

gcaagauacu uaacucgagg auacucauua auaauuaaag auguaacuga agaagacgcu     1200

ggaaauuaca caauacuauu auccauuaaa cagucaaacg uauuuaagaa ucuuaccgca     1260

acacuuauug uaaaugucaa accccaaaua uaugaaaaag caguguccuc auucccagac     1320

ccagcacucu acccauuagg aucccgacaa auacuuacuu guacugcaua ugguaucccu     1380

caaccuacua uaaaaugguu uuggcaucca uguaaucaua accauucaga agccagaugc     1440

gauuuuugua guaauaacga agaaaguuuu auauuagaug cagauucaaa caugggaaac     1500

aggauugaau caauaacuca gcgaauggcu auaauagaag gcaaaaauaa aauggcauca     1560

accuugguag uugcagacuc acgaauaagu ggcauuuaca ucugcaucgc aucaaauaaa     1620

gucggcacug ucggaagaaa uauaucauuc uacaucacag acguacccaa uggauuccac     1680

guuaacuugg aaaaaaugcc aacagaagga gaagacuuaa aauuaucuug uacaguuaau     1740

aaauuccuau acagagaugu uaccuggauc cuucuaagaa caguuaauaa ucgaacaaug     1800

cauuacucca uaucgaagca aaaaauggca aucacaaaag aacauuccau aacauuaaau     1860

cuuacaauca ugaaugucag ccuacaagac agcggaaccu augcaugccg cgcacgcaac     1920

guauauacug gugaagaaau uuuacaaaag aaagagauaa cuauacgaga ccaagaagca     1980

ccauaccuuu uaagaaaucu uucagaucac acgguugcua ucucaucaag uaccacucua     2040

gauugucaug caaacggcgu accagaaccc caaauaacuu gguucaaaaa caaccacaaa     2100

auccaacagg aaccaggaau uauauuaggu cccggauccu ccacucucuu uauugaaaga     2160

guuacugaag aggaugaagg uguuuaucac uguaaagcua caaaucaaaa aggaagcgua     2220

gaaagcagug cuuaucuuac cguucaagga acaucagaca aaaguaaucu ggaacuaauu     2280

acucuaacau gcacuugugu agcagcuacc cuuuucuggc uucucuugac acuauuuauc     2340

cguaaaauga aacgcucaag cucugagauc aaaacagacu accuuucuau aauaauggau     2400

ccagacgaag uuccauuaga ugaacaaugu gaacgacuuc cguaugaugc aaguaaaugg     2460

gaauucgcca gagaacgucu aaaauuagga aaaucuuuag gacguggagc cuuuggcaaa     2520

guuguucaag cuucagccuu uggaauaaag aaaagcccaa cauguagaac uguagcaguc     2580

aaaaugcuaa aagaaggugc uacagcaucu gaauacaaag cguuaaugac agaauugaaa     2640

auccuaacac acauuggcca ccaucuaaac gucgucaauu uguuaggagc uugcacuaaa     2700

caaggaggac cauuaauggu aauaguagaa uauugcaaau acggcaaucu aagcaauuac     2760

cucaaaucua aaagagaccu auuuuuucua aauaaagaug cugcacuuca cauggaaccu     2820

aaaaaggaaa aaauggagcc aggcuuagaa caaggaaaaa aaccacgacu ggacagcguc     2880

acaucaucag aauccuucgc auccucagga uuucaagaag auaaaucuuu gucagauguu     2940

gaagaagaag aagacucaga uggauuuuau aaagaaccaa uuacgaugga agacuuaaua     3000

ucguauucuu uucagguagc ucgcggcaug gaauuccuaa guucaaggaa auguauacau     3060

agagaccuag cugccagaaa cauccuccuc agugaaaaua acguuguaaa aauaugugac     3120

uuugguuuag cuagagauau auauaaaaau cccgauuacg uacgaaaagg cgacacgcga     3180

cucccacuca aauggauggc cccugaaagu aucuucgaua aaauauacuc aaccaagucu     3240

gacguauggu ccuauggagu cuuacucugg gaaauuuucu cacuuggagg gucccccuac     3300

ccagguguuc aaauggacga agauuuuugu aguagacuaa gagagggaau gaggaugcgc     3360

gcacccgaau acagcacccc cgaaauauau caaauaaugc uugacuguug gcauagagac     3420

cccaaagaaa gaccacgcuu cgcagaauua guagaaaaac uaggagaccu uuuacaggcg     3480

aacguacagc aagauggcaa agacuauauc ccaauaaaug caauacuaac aggaaauagc     3540

ggguucaccu acuccacacc cgcuuuuagu gaagauuuuu ucaaagaguc gauuagcgca     3600

ccgaaauuua acucaggaag cagcgaugau guucgauaug uaaaugcauu caaauucaug     3660

aguuuagaac gcauaaaaac uuuugaagaa uuacuaccca acgcaaccuc aauguuugac     3720

gauuaucaag gagauucaag cacacuacua gcaaguccga uguuaaaaag auucaccugg     3780

accgacucaa aaccgaaagc cagucuaaaa auagaucuua gagugaccag caaaucaaaa     3840

gaauccgggc uaucugacgu uuccagaccu ucauuuuguc auucauccug uggacacgua     3900

uccgaaggaa aacgacgcuu uaccuacgau caugcagaac uggaaagaaa gauagcuugu     3960

uguucaccuc caccagauua uaauucagua guucuauaua guacaccccc aauuuaa        4017


<210>  7505
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  sTie2__Homo_sapiens__B5A953

<400>  7505

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Lys Ala Arg His Thr Glu Asp Asp 
            340                 345                 350         


Pro Lys Asp Ser Gly Phe Ala Arg Ser Tyr Arg Ser Lys Gln Trp 
        355                 360                 365         


<210>  7506
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  sTie2__Homo_sapiens__ACF47627

<400>  7506
auggacucuu uagccagcuu aguucucugu ggagucagcu ugcuccuuuc uggaacugug       60

gaaggugcca uggacuugau cuugaucaau ucccuaccuc uuguaucuga ugcugaaaca      120

ucucucaccu gcauugccuc uggguggcgc ccccaugagc ccaucaccau aggaagggac      180

uuugaagccu uaaugaacca gcaccaggau ccgcuggaag uuacucaaga ugugaccaga      240

gaaugggcua aaaaaguugu uuggaagaga gaaaaggcua guaagaucaa uggugcuuau      300

uucugugaag ggcgaguucg aggagaggca aucaggauac gaaccaugaa gaugcgucaa      360

caagcuuccu uccuaccagc uacuuuaacu augacugugg acaagggaga uaacgugaac      420

auaucuuuca aaaagguauu gauuaaagaa gaagaugcag ugauuuacaa aaaugguucc      480

uucauccauu cagugccccg gcaugaagua ccugauauuc uagaaguaca ccugccucau      540

gcucagcccc aggaugcugg aguguacucg gccagguaua uaggaggaaa ccucuucacc      600

ucggccuuca ccaggcugau aguccggaga ugugaagccc agaagugggg accugaaugc      660

aaccaucucu guacugcuug uaugaacaau ggugucugcc augaagauac uggagaaugc      720

auuugcccuc cuggguuuau gggaaggacg ugugagaagg cuugugaacu gcacacguuu      780

ggcagaacuu guaaagaaag gugcagugga caagagggau gcaagucuua uguguucugu      840

cucccugacc ccuaugggug uuccugugcc acaggcugga agggucugca gugcaaugaa      900

gcaugccacc cugguuuuua cgggccagau uguaagcuua ggugcagcug caacaauggg      960

gagaugugug aucgcuucca aggaugucuc ugcucuccag gauggcaggg gcuccagugu     1020

gagagagaag guaaagcaag gcauacagag gaugacccca aagauagugg auuugccaga     1080

ucauauagaa guaaacagug guaa                                            1104


<210>  7507
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       sTie2__Homo_sapiens__ACF47627

<400>  7507
auggacagcc uggccucccu cgugcugugc ggcgucagcc ugcuccuguc cgggaccgug       60

gagggcgcca uggaccugau ccucaucaac agccugcccc ugguguccga cgcggagacc      120

agccucacgu gcaucgccuc cggguggcgc ccgcacgagc ccaucaccau cggccgggac      180

uucgaggccc ugaugaacca gcaccaggac ccccuggagg ucacccagga cgugacccgc      240

gagugggcca agaagguggu cuggaagcgg gagaaggcca gcaagaucaa cggggcguac      300

uucugcgagg gccgcgugcg gggcgaggcc auccgcaucc ggacgaugaa gaugcgccag      360

caggccuccu uccuccccgc cacccugacc augaccgugg acaaggggga caacgucaac      420

aucagcuuca agaaggugcu gaucaaggag gaggacgcgg ugaucuacaa gaacggcucc      480

uucauccaca gcgucccgcg gcacgaggug cccgacaucc ucgaggugca ccucccccac      540

gcccagcccc aggacgccgg ggucuacucc gcccgcuaca ucggcgggaa ccuguucacg      600

agcgccuuca cccggcugau cgugcgccgg ugcgaggcgc agaagugggg cccggagugc      660

aaccaccugu gcaccgccug caugaacaac ggcgugugcc acgaggacac cggggagugc      720

aucugcccgc ccggcuucau ggggcgcacg ugcgagaagg ccugcgagcu gcacaccuuc      780

ggccggaccu gcaaggagcg cugcuccggc caggaggggu gcaagagcua cgucuucugc      840

cuccccgacc ccuacggcug cuccugcgcc accgggugga agggccugca gugcaacgag      900

gccugccacc ccggguucua cggccccgac ugcaagcugc ggugcagcug caacaacggc      960

gagaugugcg accgcuucca ggggugccuc ugcucccccg gcuggcaggg gcugcagugc     1020

gagcgggagg gcaaggcgcg ccacacggag gacgacccga aggacagcgg guucgcccgg     1080

agcuaccgcu ccaagcagug guga                                            1104


<210>  7508
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       sTie2__Homo_sapiens__ACF47627

<400>  7508
auggacuccc ucgccucccu cguccucugc ggcgucuccc uccuccucuc cggcaccguc       60

gagggcgcca uggaccucau ccucaucaac ucccuccccc ucgucuccga cgccgagacc      120

ucccucaccu gcaucgccuc cggcuggcgc ccccacgagc ccaucaccau cggccgcgac      180

uucgaggccc ucaugaacca gcaccaggac ccccucgagg ucacccagga cgucacccgc      240

gagugggcca agaaggucgu cuggaagcgc gagaaggccu ccaagaucaa cggcgccuac      300

uucugcgagg gccgcguccg cggcgaggcc auccgcaucc gcaccaugaa gaugcgccag      360

caggccuccu uccuccccgc cacccucacc augaccgucg acaagggcga caacgucaac      420

aucuccuuca agaagguccu caucaaggag gaggacgccg ucaucuacaa gaacggcucc      480

uucauccacu ccgucccccg ccacgagguc cccgacaucc ucgaggucca ccucccccac      540

gcccagcccc aggacgccgg cgucuacucc gcccgcuaca ucggcggcaa ccucuucacc      600

uccgccuuca cccgccucau cguccgccgc ugcgaggccc agaagugggg ccccgagugc      660

aaccaccucu gcaccgccug caugaacaac ggcgucugcc acgaggacac cggcgagugc      720

aucugccccc ccggcuucau gggccgcacc ugcgagaagg ccugcgagcu ccacaccuuc      780

ggccgcaccu gcaaggagcg cugcuccggc caggagggcu gcaaguccua cgucuucugc      840

cuccccgacc ccuacggcug cuccugcgcc accggcugga agggccucca gugcaacgag      900

gccugccacc ccggcuucua cggccccgac ugcaagcucc gcugcuccug caacaacggc      960

gagaugugcg accgcuucca gggcugccuc ugcucccccg gcuggcaggg ccuccagugc     1020

gagcgcgagg gcaaggcccg ccacaccgag gacgacccca aggacuccgg cuucgcccgc     1080

uccuaccgcu ccaagcagug guga                                            1104


<210>  7509
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       sTie2__Homo_sapiens__ACF47627

<400>  7509
auggacagcc uggccucccu cguucuuugc ggcgucucuc uguuguuauc agggaccguu       60

gagggagcua uggaucugau ccuaauuaac agucuccccc uggugagcga cgcagaaaca      120

ucccuuacuu guauagccuc ugguuggaga ccucacgagc caaucacgau uggcagggau      180

uucgaagcgc ugaugaauca gcaucaagac ccguuggagg uaacccagga ugugacacgg      240

gaaugggcua agaaagucgu guggaagcgc gagaaagccu cgaagaucaa cggggcauac      300

uuuugcgagg gacgaguucg uggcgaagcc auuagaauca ggacuaugaa aaugcggcag      360

caggcuucau uccuccccgc aacccugaca augaccgugg acaaggguga uaaugucaac      420

aucagcuuua agaaagugcu gauaaaggag gaagacgccg uaauuuauaa aaaugggagu      480

uucauccacu ccguuccucg ccaugaggug ccagauauuc ucgaggucca cuuaccccau      540

gcucaaccuc aggacgccgg aguguacucu gcgagauaua ucggcggcaa ccuguuuacu      600

agcgcauuca caaggcuuau agugcggcgc ugugaagccc agaagugggg gccagagugc      660

aaucacuugu guaccgcuug caugaacaau ggagucuguc acgaagauac gggugagugc      720

auuugucccc cuggcuuuau ggggcgaacu ugcgaaaaag ccugugagcu gcauaccuuc      780

ggaagaacau gcaaggagag gugcuccggc caggaagguu guaagucaua cguguuuugc      840

cuaccagacc cguaugggug uaguugcgca acuggaugga aaggccucca auguaacgag      900

gcuugccacc ccggcuucua cgggccugau uguaagcugc ggugcagcug uaauaacgga      960

gaaaugugcg accguuuuca ggguugucuu ugcucuccag gcuggcaggg gcugcagugc     1020

gagcgcgaag gaaaagccag acauaccgag gacgauccca aggacuccgg cuucgcgagg     1080

ucauaucgga gcaaacaaug guga                                            1104


<210>  7510
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       sTie2__Homo_sapiens__ACF47627

<400>  7510
auggacagcc uggccagccu ggugcugugc ggcgugagcc ugcugcugag cggcaccgug       60

gagggcgcca uggaccugau ccugaucaac agccugcccc uggugagcga cgccgagacc      120

agccugaccu gcaucgccag cggcuggaga ccccacgagc ccaucaccau cggcagagac      180

uucgaggccc ugaugaacca gcaccaggac ccccuggagg ugacccagga cgugaccaga      240

gagugggcca agaagguggu guggaagaga gagaaggcca gcaagaucaa cggcgccuac      300

uucugcgagg gcagagugag aggcgaggcc aucagaauca gaaccaugaa gaugagacag      360

caggccagcu uccugcccgc cacccugacc augaccgugg acaagggcga caacgugaac      420

aucagcuuca agaaggugcu gaucaaggag gaggacgccg ugaucuacaa gaacggcagc      480

uucauccaca gcgugcccag acacgaggug cccgacaucc uggaggugca ccugccccac      540

gcccagcccc aggacgccgg cguguacagc gccagauaca ucggcggcaa ccuguucacc      600

agcgccuuca ccagacugau cgugagaaga ugcgaggccc agaagugggg ccccgagugc      660

aaccaccugu gcaccgccug caugaacaac ggcgugugcc acgaggacac cggcgagugc      720

aucugccccc ccggcuucau gggcagaacc ugcgagaagg ccugcgagcu gcacaccuuc      780

ggcagaaccu gcaaggagag augcagcggc caggagggcu gcaagagcua cguguucugc      840

cugcccgacc ccuacggcug cagcugcgcc accggcugga agggccugca gugcaacgag      900

gccugccacc ccggcuucua cggccccgac ugcaagcuga gaugcagcug caacaacggc      960

gagaugugcg acagauucca gggcugccug ugcagccccg gcuggcaggg ccugcagugc     1020

gagagagagg gcaaggccag acacaccgag gacgacccca aggacagcgg cuucgccaga     1080

agcuacagaa gcaagcagug guga                                            1104


<210>  7511
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       sTie2__Homo_sapiens__ACF47627

<400>  7511
auggacagcc uggccucccu cgugcugugc ggcgucucuc uucugcucag cgggaccguu       60

gagggagcua uggaucugau ccuuauuaac ucccugcccc ucgugucuga cgccgaaaca      120

agccugacgu guaucgcguc cggcuggaga ccucacgagc cgauuaccau cgggcgggau      180

uucgaagcuc ugaugaauca gcaucaagac ccccucgagg ugacacagga ugucacccgc      240

gaaugggcca agaaaguggu uuggaagaga gagaaagccu cuaagauuaa cggagcuuac      300

uuuugcgagg gccgggugcg cggggaagcc aucagaaucc ggacaaugaa aaugcgccag      360

caggcuagcu uccugccugc cacccuuaca augaccgucg acaagggaga uaaugugaac      420

auuuccuuua agaaaguucu gaucaaggag gaagacgcgg ugauuuauaa aaauggcagc      480

uucauccacu cuguccccag acaugaggug ccugauauuc ucgaggugca ucugccccac      540

gcccaaccuc aggacgcugg cgucuacucc gcccgguaua ucgggggaaa ccuuuuuacg      600

agcgcuuuca cccgccugau uguuagacgg ugugaagccc agaagugggg cccggagugc      660

aaucaccucu guacagcgug caugaacaau gggguguguc acgaagauac cggagagugc      720

aucugucccc cuggcuuuau ggggcgcaca ugcgaaaaag ccugugagcu gcauaccuuc      780

ggaagaacgu gcaaggagcg gugcucuggc caggaaggcu guaaguccua cguguuuugc      840

cugcccgacc cuuaugggug uagcugcgcu acaggaugga aaggccucca auguaacgag      900

gccugccacc ccggguucua cggaccggau uguaagcugc gcugcucuug uaauaacggc      960

gaaaugugcg acagauuuca ggggugucuu ugcuccccug gauggcaggg ccugcagugc     1020

gagcgggaag gcaaagcuag acauaccgag gacgauccca aggacagcgg guucgcccgc     1080

uccuaucggu cuaaacaaug guga                                            1104


<210>  7512
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       sTie2__Homo_sapiens__ACF47627

<400>  7512
auggauagcu uagcaucauu aguauuaugu ggaguaaguu uacuauuauc aggaacagug       60

gaaggagcaa uggaucuaau auuaauaaau agucuaccac uuguuucaga cgcagaaaca      120

ucauuaacau guauagccag cggauggcga ccacaugaac caauaacaau aggaagagau      180

uuugaagcac uaaugaauca acaucaagau ccauuagaag uaacacaaga uguaacaaga      240

gaaugggcaa aaaaagucgu uuggaaaaga gaaaaagcau caaaaauuaa cggagcauau      300

uuuugugaag gaagaguaag aggugaagca auaagaauaa gaacuaugaa aaugagacaa      360

caagcaucau ucuugccagc aacacuaaca augaccguag auaaaggaga uaauguaaau      420

auaaguuuca aaaaaguacu uauuaaagaa gaagacgcag uaauauauaa aaacggauca      480

uuuauacaua gcguaccaag acacgaagua ccagauauau uagaaguaca cuuaccacau      540

gcacaaccac aagaugcugg aguauacagu gcuagauaua uaggaggaaa uuuauucaca      600

agugcauuua caagauuaau uguaagaaga ugugaagcgc aaaaaugggg uccagaaugc      660

aaccacuuau guacagcaug caugaauaau ggaguauguc acgaagacac aggcgaaugc      720

auauguccac caggauuuau gggaagaaca ugugaaaaag caugugaauu acacacauuu      780

ggaagaacau guaaagaaag augcagugga caagaaggau guaaaaguua uguauucugu      840

uuaccagacc cauauggaug cucaugcgca acgggaugga aaggacuaca auguaaugaa      900

gcaugucauc caggguuuua uggaccagau uguaaauuaa gauguaguug caauaaugga      960

gaaaugugug auagauuuca gggcuguuug uguaguccag gauggcaagg auuacaaugu     1020

gaaagagaag gaaaagcuag acauacagaa gacgauccaa aagauucagg auuugcaaga     1080

aguuauagaa gcaagcaaug guaa                                            1104


<210>  7513
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIMP-1__Homo_sapiens__P01033

<400>  7513

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  7514
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIMP-1__Homo_sapiens__AAA52436

<400>  7514
auggcccccu uugagccccu ggcuucuggc auccuguugu ugcuguggcu gauagccccc       60

agcagggccu gcaccugugu cccaccccac ccacagacgg ccuucugcaa uuccgaccuc      120

gucaucaggg ccaaguucgu ggggacacca gaagucaacc agaccaccuu auaccagcgu      180

uaugagauca agaugaccaa gauguauaaa ggguuccaag ccuuagggga ugccgcugac      240

auccgguucg ucuacacccc cgccauggag agugucugcg gauacuucca caggucccac      300

aaccgcagcg aggaguuucu cauugcugga aaacugcagg auggacucuu gcacaucacu      360

accugcaguu ucguggcucc cuggaacagc cugagcuuag cucagcgccg gggcuucacc      420

aagaccuaca cuguuggcug ugaggaaugc acaguguuuc ccuguuuauc cauccccugc      480

aaacugcaga guggcacuca uugcuugugg acggaccagc uccuccaagg cucugaaaag      540

ggcuuccagu cccgucaccu ugccugccug ccucgggagc cagggcugug caccuggcag      600

ucccugcggu cccagauagc cuga                                             624


<210>  7515
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7515
auggcccccu ucgagccgcu ggccagcggc auccuccugc ugcucuggcu gaucgcgccc       60

ucccgcgccu gcacgugcgu gccgccccac ccccagaccg ccuucugcaa cagcgaccug      120

gucauccggg ccaaguucgu ggggaccccc gaggugaacc agaccacccu cuaccagcgc      180

uacgagauca agaugaccaa gauguacaag ggcuuccagg cccuggggga cgcggccgac      240

auccgguucg ucuacacgcc cgccauggag uccgugugcg gcuacuucca ccgcagccac      300

aaccgguccg aggaguuccu gaucgccggg aagcuccagg acggccugcu gcacaucacg      360

accugcagcu ucguggcgcc cuggaacucc cucagccugg cccagcgccg gggcuucacc      420

aagaccuaca ccgucgggug cgaggagugc accguguucc cgugccuguc cauccccugc      480

aagcuccaga gcggcaccca cugccugugg acggaccagc ugcuccaggg guccgagaag      540

ggcuuccaga gccgccaccu ggccugccug ccccgggagc ccgggcucug caccuggcag      600

ucccugcgca gccagaucgc cuga                                             624


<210>  7516
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7516
auggcccccu ucgagccccu cgccuccggc auccuccucc uccucuggcu caucgccccc       60

ucccgcgccu gcaccugcgu ccccccccac ccccagaccg ccuucugcaa cuccgaccuc      120

gucauccgcg ccaaguucgu cggcaccccc gaggucaacc agaccacccu cuaccagcgc      180

uacgagauca agaugaccaa gauguacaag ggcuuccagg cccucggcga cgccgccgac      240

auccgcuucg ucuacacccc cgccauggag uccgucugcg gcuacuucca ccgcucccac      300

aaccgcuccg aggaguuccu caucgccggc aagcuccagg acggccuccu ccacaucacc      360

accugcuccu ucgucgcccc cuggaacucc cucucccucg cccagcgccg cggcuucacc      420

aagaccuaca ccgucggcug cgaggagugc accgucuucc ccugccucuc cauccccugc      480

aagcuccagu ccggcaccca cugccucugg accgaccagc uccuccaggg cuccgagaag      540

ggcuuccagu cccgccaccu cgccugccuc ccccgcgagc ccggccucug caccuggcag      600

ucccuccgcu cccagaucgc cuga                                             624


<210>  7517
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7517
auggcccccu ucgagccucu ggcuagcggc auccuccuuc uguugugguu aauugcacca       60

uccagagccu gcaccugugu gccgccccac ccucagacag cguuuugcaa uucugaccug      120

gucauaaggg cuaaguucgu ugggacucca gaagugaauc aaacgacccu auaccagcgg      180

uaugagauca aaaugacaaa gauguacaaa ggauuucagg cccucgguga ugcagccgac      240

auucgcuucg uauauacucc cgcuauggaa ucagugugug gcuacuuuca ucgaagucac      300

aaccguagcg aggaguuccu gaucgcaggg aaacuucagg auggacuguu gcauauuacc      360

acaugcuccu uugucgcccc uuggaacucu cucucgcugg cucaaagaag gggcuucacc      420

aagacuuaua caguggguug ugaagagugc accguuuuuc caugucuguc aauccccugc      480

aagcuccaga gcgggacgca cuguuuaugg acugaccagc ugcuucaggg aagugaaaag      540

ggcuuccaau cccggcauuu ggccugccug ccucgcgagc caggccuaug uaccuggcag      600

ucucucagaa gccagauagc guga                                             624


<210>  7518
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7518
auggcccccu ucgagccccu ggccagcggc auccugcugc ugcuguggcu gaucgccccc       60

agcagagccu gcaccugcgu gcccccccac ccccagaccg ccuucugcaa cagcgaccug      120

gugaucagag ccaaguucgu gggcaccccc gaggugaacc agaccacccu guaccagaga      180

uacgagauca agaugaccaa gauguacaag ggcuuccagg cccugggcga cgccgccgac      240

aucagauucg uguacacccc cgccauggag agcgugugcg gcuacuucca cagaagccac      300

aacagaagcg aggaguuccu gaucgccggc aagcugcagg acggccugcu gcacaucacc      360

accugcagcu ucguggcccc cuggaacagc cugagccugg cccagagaag aggcuucacc      420

aagaccuaca ccgugggcug cgaggagugc accguguucc ccugccugag cauccccugc      480

aagcugcaga gcggcaccca cugccugugg accgaccagc ugcugcaggg cagcgagaag      540

ggcuuccaga gcagacaccu ggccugccug cccagagagc ccggccugug caccuggcag      600

agccugagaa gccagaucgc cuga                                             624


<210>  7519
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7519
auggcccccu ucgagccucu ggcuagcggc auccuccugc uucuguggcu cauugccccg       60

uccagagcgu gcaccugugu gcccccucac ccccagacag cuuuuugcaa uucugaccug      120

gucauccggg ccaaguucgu ugggacgccu gaagugaauc aaaccacacu uuaccagcgc      180

uaugagauua aaaugaccaa gauguacaaa ggauuucagg cccugggcga ugcugccgac      240

aucagauucg uguauacacc cgcuauggaa agcgucugug gguacuuuca ucggucccac      300

aaccgcucug aggaguuccu cauugccgga aagcugcagg auggccugcu ccauaucacc      360

acaugcagcu uuguggcgcc uuggaacucc cugucucuug cccaaagacg gggguucacc      420

aaaacguaua ccguuggaug ugaagagugc acaguguuuc cgugucugag cauccccugc      480

aagcuccagu ccggcaccca cugucugugg acagaccagc uucugcaggg cagcgaaaag      540

ggguuccaau cucgccaucu cgcuugccug ccuagagagc ccggacugug uaccuggcag      600

ucccuccgga gccagauugc cuga                                             624


<210>  7520
<211>  624
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TIMP-1__Homo_sapiens__AAA52436

<400>  7520
auggcaccau ucgaacccuu agcaucagga auacuacuac uacuauggcu aauagcacca       60

ucaagagcau gcacaugcgu accaccacac ccacaaaccg cauucugcaa cucagaccua      120

guaauaagag caaaauucgu aggaacacca gaaguaaauc aaaccacauu auaccaaaga      180

uacgaaauaa aaaugacaaa aauguacaaa ggauuccaag cacuaggaga cgcagccgac      240

auaagauuug uauacacacc agcaauggaa ucaguaugug gauacuucca ccgaucacac      300

aaccgauccg aagaauuuuu aauagcagga aaauuacaag acggacuauu acacauaaca      360

acaugcucau ucguagcacc uuggaacuca cuuucacuag cacaaagaag aggauucaca      420

aaaacauaca cagucggaug cgaagaaugu acaguauucc caugccuauc cauaccaugc      480

aaacuacaau caggaacaca cugccuaugg acagaccaac uauuacaagg aucagaaaaa      540

ggauuccaau caagacaccu agcaugccua cccagagaac caggauuaug cacauggcaa      600

ucacuaagau cccaaauagc cuaa                                             624


<210>  7521
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIMP-2__Homo_sapiens__P16035

<400>  7521

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  7522
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIMP-2__Homo_sapiens__AAA59581

<400>  7522
augggcgccg cggcccgcac ccugcggcug gcgcucggcc uccugcugcu ggcgacgcug       60

cuucgcccgg ccgacgccug cagcugcucc ccggugcacc cgcaacaggc guuuugcaau      120

gcagauguag ugaucagggc caaagcgguc agugagaagg aaguggacuc uggaaacgac      180

auuuauggca acccuaucaa gaggauccag uaugagauca agcagauaaa gauguucaaa      240

gggccugaga aggauauaga guuuaucuac acggcccccu ccucggcagu gugugggguc      300

ucgcuggacg uuggaggaaa gaaggaauau cucauugcag gaaaggccga gggggacggc      360

aagaugcaca ucacccucug ugacuucauc gugcccuggg acacccugag caccacccag      420

aagaagagcc ugaaccacag guaccagaug ggcugcgagu gcaagaucac gcgcugcccc      480

augaucccgu gcuacaucuc cuccccggac gagugccucu ggauggacug ggucacagag      540

aagaacauca acgggcacca ggccaaguuc uucgccugca ucaagagaag ugacggcucc      600

ugugcguggu accgcggcgc ggcgcccccc aagcaggagu uucucgacau cgaggaccca      660

uaa                                                                    663


<210>  7523
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7523
augggcgccg ccgcgcgcac ccugcggcuc gcccuggggc ugcuccugcu ggccacccuc       60

cugcgccccg ccgacgccug cagcugcucc cccgugcacc cccagcaggc guucugcaac      120

gccgacgucg ugauccgggc caaggccgug agcgagaagg aggucgacuc cggcaacgac      180

aucuacggga accccaucaa gcgcauccag uacgagauca agcagaucaa gauguucaag      240

ggccccgaga aggacaucga guucaucuac acggcgccga gcuccgccgu gugcggggug      300

agccuggacg ucggcggcaa gaaggaguac cucaucgccg ggaaggccga gggcgacggg      360

aagaugcaca ucacccugug cgacuucauc gugcccuggg acacccuguc caccacgcag      420

aagaaguccc ucaaccaccg guaccagaug ggcugcgagu gcaagaucac ccgcugcccc      480

augauccccu gcuacaucag cagcccggac gagugccugu ggauggacug ggugaccgag      540

aagaacauca acgggcacca ggccaaguuc uucgcgugca ucaagcgguc cgacggcagc      600

ugcgccuggu accgcggcgc cgccccgccc aagcaggagu uccuggacau cgaggacccc      660

uga                                                                    663


<210>  7524
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7524
augggcgccg ccgcccgcac ccuccgccuc gcccucggcc uccuccuccu cgccacccuc       60

cuccgccccg ccgacgccug cuccugcucc cccguccacc cccagcaggc cuucugcaac      120

gccgacgucg ucauccgcgc caaggccguc uccgagaagg aggucgacuc cggcaacgac      180

aucuacggca accccaucaa gcgcauccag uacgagauca agcagaucaa gauguucaag      240

ggccccgaga aggacaucga guucaucuac accgcccccu ccuccgccgu cugcggcguc      300

ucccucgacg ucggcggcaa gaaggaguac cucaucgccg gcaaggccga gggcgacggc      360

aagaugcaca ucacccucug cgacuucauc guccccuggg acacccucuc caccacccag      420

aagaaguccc ucaaccaccg cuaccagaug ggcugcgagu gcaagaucac ccgcugcccc      480

augauccccu gcuacaucuc cucccccgac gagugccucu ggauggacug ggucaccgag      540

aagaacauca acggccacca ggccaaguuc uucgccugca ucaagcgcuc cgacggcucc      600

ugcgccuggu accgcggcgc cgcccccccc aagcaggagu uccucgacau cgaggacccc      660

uga                                                                    663


<210>  7525
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7525
augggcgccg cugcaagaac ccugaggcuc gcccuugggc uguuguuacu ggcgacacua       60

cuccggcccg cugacgccug cagcuguucc ccugugcacc cacagcaagc auucugcaac      120

gccgaugucg uuauccgcgc uaaggcagug ucugagaaag aaguagacuc aggaaaugau      180

auuuacggua acccgauaaa gcgaauccag uaugagauua aacagaucaa gauguuuaaa      240

ggccccgaaa aggacauuga guucaucuac acugccccua guagcgcugu gugugggguc      300

ucccuggaug ugggaggcaa gaaagaauau cuuauagccg guaaggcgga gggggacgga      360

aaaaugcaua ucacgcugug cgauuuuauu guuccauggg acaccuuguc uacaacucag      420

aagaaaucgc ucaaucaccg uuaccaaaug ggcugugagu gcaagaucac cagauguccc      480

augauuccuu gcuauaucuc aagcccagau gaaugucugu ggauggacug ggugacagag      540

aagaacauaa auggccauca ggcaaaauuc uuugccugca uuaagaggag ugaugggucc      600

ugugcuuggu accggggagc cgcacccccu aaacaggagu uccuggacau cgaagaucca      660

uga                                                                    663


<210>  7526
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7526
augggcgccg ccgccagaac ccugagacug gcccugggcc ugcugcugcu ggccacccug       60

cugagacccg ccgacgccug cagcugcagc cccgugcacc cccagcaggc cuucugcaac      120

gccgacgugg ugaucagagc caaggccgug agcgagaagg agguggacag cggcaacgac      180

aucuacggca accccaucaa gagaauccag uacgagauca agcagaucaa gauguucaag      240

ggccccgaga aggacaucga guucaucuac accgccccca gcagcgccgu gugcggcgug      300

agccuggacg ugggcggcaa gaaggaguac cugaucgccg gcaaggccga gggcgacggc      360

aagaugcaca ucacccugug cgacuucauc gugcccuggg acacccugag caccacccag      420

aagaagagcc ugaaccacag auaccagaug ggcugcgagu gcaagaucac cagaugcccc      480

augauccccu gcuacaucag cagccccgac gagugccugu ggauggacug ggugaccgag      540

aagaacauca acggccacca ggccaaguuc uucgccugca ucaagagaag cgacggcagc      600

ugcgccuggu acagaggcgc cgcccccccc aagcaggagu uccuggacau cgaggacccc      660

uga                                                                    663


<210>  7527
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7527
augggcgccg cugccagaac ccugcggcuc gcgcuggggc uucugcuccu ggcuacacuu       60

cugcgccccg ccgacgccug cagcuguucc ccugugcacc cgcagcaggc uuucugcaac      120

gccgaugucg uuaucagagc uaaggccgug ucugagaaag aaguggacag cggaaaugau      180

auuuacggca accccaucaa gcggauucaa uaugagauca aacagauuaa gauguuuaaa      240

gggccugaaa aggacaucga guucaucuac acggcgcccu ccucugccgu cuguggagug      300

agccucgaug uuggcgggaa gaaagaauau cugauugcug gaaaggccga gggcgacggc      360

aaaaugcaua ucacccugug cgauuuuauu gugccuuggg acacacucuc caccacacag      420

aagaaaucuc ugaaucaccg cuaccaaaug gggugugagu gcaagaucac cagauguccc      480

augauuccuu gcuauaucag cuccccggau gaaugucuuu ggauggacug ggucacagag      540

aagaacauua auggacauca ggcuaaauuc uuugccugca ucaagcggag cgauggcucu      600

ugugcguggu accgcggggc cgcucccccu aaacaggagu uccuggacau cgaagauccc      660

uga                                                                    663


<210>  7528
<211>  663
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TIMP-2__Homo_sapiens__AAA59581

<400>  7528
augggagcag cagcaagaac auuaagauua gcacuaggac uacuacuauu agcaacacua       60

cuaagaccag cagacgcaug cagcugcuca ccaguacacc cacaacaagc auucugcaac      120

gcagacguag uaauaagagc aaaagcagua ucagaaaaag aagucgacuc aggaaacgac      180

auauauggaa acccaauaaa aagaauacaa uacgaaauaa aacaaauaaa aauguucaaa      240

ggaccagaaa aagacauaga auucauauau acagcaccau caucagcagu augcggagua      300

ucacuagacg uaggaggaaa aaaagaauac uuaauagcag gaaaagcaga aggagacgga      360

aaaaugcaca uaacacuaug cgacuucaua guaccauggg acacacuauc aacaacccaa      420

aaaaaaagcu uaaaccacag auaccaaaug ggaugcgaau gcaaaauaac aagaugccca      480

augauaccau gcuacauauc aaguccagau gaaugcuuau ggauggacug gguaacagaa      540

aaaaacauca acggacacca agcaaaauuc uucgcaugca uaaaaagauc agacggaagu      600

ugcgcauggu auagaggagc agcaccacca aaacaagaau uccuagacau agaagaucca      660

uaa                                                                    663


<210>  7529
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIMP-3__Homo_sapiens__P35625

<400>  7529

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  7530
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIMP-3__Homo_sapiens__AAA17672

<400>  7530
augaccccuu ggcucgggcu caucgugcuc cugggcagcu ggagccuggg ggacuggggc       60

gccgaggcgu gcacaugcuc gcccagccac ccccaggacg ccuucugcaa cuccgacauc      120

gugauccggg ccaagguggu ggggaagaag cugguaaagg aggggcccuu cggcacgcug      180

gucuacacca ucaagcagau gaagauguac cgaggcuuca ccaagaugcc ccaugugcag      240

uacauccaua cggaagcuuc cgagagucuc uguggccuua agcuggaggu caacaaguac      300

caguaccugc ugacaggucg cgucuaugau ggcaagaugu acacggggcu gugcaacuuc      360

guggagaggu gggaccagcu cacccucucc cagcgcaagg ggcugaacua ucgguaucac      420

cuggguugua acugcaagau caaguccugc uacuaccugc cuugcuuugu gacuuccaag      480

aacgaguguc ucuggaccga caugcucucc aauuucgguu acccuggcua ccaguccaaa      540

cacuacgccu gcauccggca gaagggcggc uacugcagcu gguaccgagg augggccccc      600

ccggauaaaa gcaucaucaa ugccacagac cccuga                                636


<210>  7531
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7531
augacccccu ggcugggccu caucgugcug cuggggagcu ggucccucgg cgacuggggc       60

gccgaggccu gcacgugcag cccgucccac ccccaggacg cguucugcaa cagcgacauc      120

gucauccgcg ccaagguggu ggggaagaag cuggucaagg aggggcccuu cggcacccug      180

guguacacca ucaagcagau gaagauguac cggggcuuca ccaagaugcc ccacgugcag      240

uacauccaca ccgaggccuc cgagagccuc ugcgggcuga agcuggaggu caacaaguac      300

caguaccucc ugacgggccg cguguacgac gggaagaugu acaccggccu gugcaacuuc      360

guggagcggu gggaccagcu cacccugucc cagcgcaagg ggcugaacua ccgguaccac      420

cucggcugca acugcaagau caagagcugc uacuaccugc cgugcuucgu caccuccaag      480

aacgagugcc uguggacgga caugcucagc aacuucggcu accccgggua ccaguccaag      540

cacuacgccu gcauccgcca gaagggcggg uacugcagcu gguaccgggg cugggccccg      600

cccgacaagu ccaucaucaa cgcgaccgac cccuga                                636


<210>  7532
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7532
augacccccu ggcucggccu caucguccuc cucggcuccu ggucccucgg cgacuggggc       60

gccgaggccu gcaccugcuc ccccucccac ccccaggacg ccuucugcaa cuccgacauc      120

gucauccgcg ccaaggucgu cggcaagaag cucgucaagg agggccccuu cggcacccuc      180

gucuacacca ucaagcagau gaagauguac cgcggcuuca ccaagaugcc ccacguccag      240

uacauccaca ccgaggccuc cgagucccuc ugcggccuca agcucgaggu caacaaguac      300

caguaccucc ucaccggccg cgucuacgac ggcaagaugu acaccggccu cugcaacuuc      360

gucgagcgcu gggaccagcu cacccucucc cagcgcaagg gccucaacua ccgcuaccac      420

cucggcugca acugcaagau caaguccugc uacuaccucc ccugcuucgu caccuccaag      480

aacgagugcc ucuggaccga caugcucucc aacuucggcu accccggcua ccaguccaag      540

cacuacgccu gcauccgcca gaagggcggc uacugcuccu gguaccgcgg cugggccccc      600

cccgacaagu ccaucaucaa cgccaccgac cccuga                                636


<210>  7533
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7533
augacccccu ggcugggccu caucgugcuu cuggggagcu gguccuuggg agacuggggu       60

gccgaggcuu gcacauguuc uccuucacac ccacaggaug cauucugcaa cagugacauu      120

gucauaagag ccaagguugu gggcaaaaag uuaguaaaag aagggccguu uggaacucug      180

guguacacga ucaagcaaau gaaaauguau aggggcuuca ccaagaugcc ccauguccag      240

uacauucaca cagaggcgag cgaaucccua uguggucuca agcuggaggu gaauaaauau      300

caguaccuuc ugacugggcg gguuuaugau ggaaagaugu acaccggcuu gugcaacuuu      360

guggaacgcu gggaccagcu cacacugucu caacgaaaag gccugaauua ucguuaccau      420

cucgggugua acugcaagau caaaucgugu uacuauuuac cuugcuucgu caccucaaag      480

aaugaguguc uguggacuga uaugcuuagc aacuuuggau acccagguua ucagaguaag      540

cacuacgcuu gcauuagaca gaaaggcggg uauuguuccu gguacagggg augggcaccc      600

ccugacaagu cuaucauaaa ugccacagau ccauga                                636


<210>  7534
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7534
augacccccu ggcugggccu gaucgugcug cugggcagcu ggagccuggg cgacuggggc       60

gccgaggccu gcaccugcag ccccagccac ccccaggacg ccuucugcaa cagcgacauc      120

gugaucagag ccaagguggu gggcaagaag cuggugaagg agggccccuu cggcacccug      180

guguacacca ucaagcagau gaagauguac agaggcuuca ccaagaugcc ccacgugcag      240

uacauccaca ccgaggccag cgagagccug ugcggccuga agcuggaggu gaacaaguac      300

caguaccugc ugaccggcag aguguacgac ggcaagaugu acaccggccu gugcaacuuc      360

guggagagau gggaccagcu gacccugagc cagagaaagg gccugaacua cagauaccac      420

cugggcugca acugcaagau caagagcugc uacuaccugc ccugcuucgu gaccagcaag      480

aacgagugcc uguggaccga caugcugagc aacuucggcu accccggcua ccagagcaag      540

cacuacgccu gcaucagaca gaagggcggc uacugcagcu gguacagagg cugggccccc      600

cccgacaaga gcaucaucaa cgccaccgac cccuga                                636


<210>  7535
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7535
augacccccu ggcugggccu caucgugcug cuugggagcu ggucccuggg agacuggggc       60

gccgaggcuu gcacauguuc uccuagccac ccgcaggaug ccuucugcaa cuccgacauu      120

gucaucagag cgaagguugu ggggaaaaag cucgugaaag aaggacccuu uggcacgcug      180

gucuacacca uuaagcaaau gaaaauguau cggggguuca caaagaugcc ucaugugcag      240

uacauccaca ccgaggcuuc ugaaagccuu uguggacuga agcucgaggu uaauaaauau      300

caguaccugc ugacaggccg cguguaugau ggcaagaugu acaccgggcu cugcaacuuu      360

gucgaaagau gggaccagcu gacacuuucc caacggaaag gacugaauua ucgcuaccau      420

cucggcugua acugcaagau uaaaucuugu uacuaucugc ccugcuucgu gaccagcaag      480

aaugaguguc uuuggacgga uaugcugucc aacuuugggu acccuggaua ucagagcaag      540

cacuacgccu gcaucagaca gaaaggcggg uauuguucuu gguaccgggg augggcuccc      600

ccugacaagu ccaucauuaa ugccaccgau ccguga                                636


<210>  7536
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TIMP-3__Homo_sapiens__AAA17672

<400>  7536
augacaccau ggcuaggacu aauaguacua cuaggaucau ggucacuagg agacugggga       60

gcagaagcau gcacaugcuc accaucacac ccacaagacg cauucugcaa cucagacaua      120

guaauaagag caaaaguagu aggaaaaaaa uuaguaaaag aaggacccuu cggaacacua      180

guauacacaa uaaaacaaau gaaaauguac agaggauuca caaaaaugcc acacguacaa      240

uacauacaca cagaagcauc agaaucacua ugcggacuaa aacuagaagu aaacaaauau      300

caauaucuau uaacaggaag aguauacgac ggaaaaaugu auacaggacu augcaacuuc      360

guagaaagau gggaccaacu aacacuauca caaagaaaag gacuaaacua cagauaccac      420

cuaggaugca auugcaaaau aaaaucaugc uacuacuuac caugcuucgu aacaucaaaa      480

aacgaaugcc uauggacaga caugcuauca aauuucggau acccagguua ccaaagcaaa      540

cacuacgcau gcauaagaca aaaaggagga uacugcucau gguacagagg augggcacca      600

ccagacaaau caauaauaaa cgcaacagac cccuaa                                636


<210>  7537
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSP-1__Homo_sapiens__P07996

<400>  7537

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 
        995                 1000                1005            


Ser Gly Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 
    1010                1015                1020                


Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp 
1025                1030                1035                1040


Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln 
                1045                1050                1055    


Gly Tyr Ser Gly Leu Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro 
            1060                1065                1070        


Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly 
        1075                1080                1085            


Gln Val Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 
    1090                1095                1100                


Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe 
1105                1110                1115                1120


Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly 
                1125                1130                1135    


Pro Ile Tyr Asp Lys Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val 
            1140                1145                1150        


Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 
        1155                1160                1165            


Asp Pro 
    1170


<210>  7538
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TSP-1__Homo_sapiens__AAI36470

<400>  7538
auggggcugg ccuggggacu aggcguccug uuccugaugc augugugugg caccaaccgc       60

auuccagagu cuggcggaga caacagcgug uuugacaucu uugaacucac cggggccgcc      120

cgcaaggggu cugggcgccg acuggugaag ggccccgacc cuuccagccc agcuuuccgc      180

aucgaggaug ccaaccugau ccccccugug ccugaugaca aguuccaaga ccugguggau      240

gcugugcggg cagaaaaggg uuuccuccuu cuggcauccc ugaggcagau gaagaagacc      300

cggggcacgc ugcuggcccu ggagcggaaa gaccacucug gccaggucuu cagcguggug      360

uccaauggca aggcgggcac ccuggaccuc agccugaccg uccaaggaaa gcagcacgug      420

gugucugugg aagaagcucu ccuggcaacc ggccagugga agagcaucac ccuguuugug      480

caggaagaca gggcccagcu guacaucgac ugugaaaaga uggagaaugc ugaguuggac      540

guccccaucc aaagcgucuu caccagagac cuggccagca ucgccagacu ccgcaucgca      600

aaggggggcg ucaaugacaa uuuccagggg gugcugcaga augugagguu ugucuuugga      660

accacaccag aagacauccu caggaacaaa ggcugcucca gcucuaccag uguccuccuc      720

acccuugaca acaacguggu gaaugguucc agcccugcca uccgcacuaa cuacauuggc      780

cacaagacaa aggacuugca agccaucugc ggcaucuccu gugaugagcu guccagcaug      840

guccuggaac ucaggggccu gcgcaccauu gugaccacgc ugcaggacag cauccgcaaa      900

gugacugaag agaacaaaga guuggccaau gagcugaggc ggccuccccu augcuaucac      960

aacggaguuc aguacagaaa uaacgaggaa uggacuguug auagcugcac ugagugucac     1020

ugucagaacu caguuaccau cugcaaaaag guguccugcc ccaucaugcc cugcuccaau     1080

gccacaguuc cugauggaga augcuguccu cgcuguuggc ccagcgacuc ugcggacgau     1140

ggcuggucuc caugguccga guggaccucc uguucuacga gcuguggcaa uggaauucag     1200

cagcgcggcc gcuccugcga uagccucaac aaccgaugug agggcuccuc gguccagaca     1260

cggaccugcc acauucagga gugugacaag agauuuaaac aggauggugg cuggagccac     1320

ugguccccgu ggucaucuug uucugugaca uguggugaug gugugaucac aaggauccgg     1380

cucugcaacu cucccagccc ccagaugaac gggaaacccu gugaaggcga agcgcgggag     1440

accaaagccu gcaagaaaga cgccugcccc aucaauggag gcuggggucc uuggucacca     1500

ugggacaucu guucugucac cuguggagga gggguacaga aacguagucg ucucugcaac     1560

aaccccacac cccaguuugg aggcaaggac ugcguuggug auguaacaga aaaccagauc     1620

ugcaacaagc aggacugucc aauugaugga ugccugucca aucccugcuu ugccggcgug     1680

aaguguacua gcuacccuga uggcagcugg aaauguggug cuuguccccc ugguuacagu     1740

ggaaauggca uccagugcac agauguugau gagugcaaag aagugccuga ugccugcuuc     1800

aaccacaaug gagagcaccg gugugagaac acggaccccg gcuacaacug ccugcccugc     1860

cccccacgcu ucaccggcuc acagcccuuc ggccagggug ucgaacaugc cacggccaac     1920

aaacaggugu gcaagccccg uaaccccugc acggauggga cccacgacug caacaagaac     1980

gccaagugca acuaccuggg ccacuauagc gaccccaugu accgcugcga gugcaagccu     2040

ggcuacgcug gcaauggcau caucugcggg gaggacacag accuggaugg cuggcccaau     2100

gagaaccugg ugugcguggc caaugcgacu uaccacugca aaaaggauaa uugccccaac     2160

cuucccaacu cagggcagga agacuaugac aaggauggaa uuggugaugc cugugaugau     2220

gacgaugaca augauaaaau uccagaugac agggacaacu guccauucca uuacaaccca     2280

gcucaguaug acuaugacag agaugaugug ggagaccgcu gugacaacug ucccuacaac     2340

cacaacccag aucaggcaga cacagacaac aauggggaag gagacgccug ugcugcagac     2400

auugauggag acgguauccu caaugaacgg gacaacugcc aguacgucua caauguggac     2460

cagagagaca cugauaugga ugggguugga gaucagugug acaauugccc cuuggaacac     2520

aauccggauc agcuggacuc ugacucagac cgcauuggag auaccuguga caacaaucag     2580

gauauugaug aagauggcca ccagaacaau cuggacaacu gucccuaugu gcccaaugcc     2640

aaccaggcug accaugacaa agauggcaag ggagaugccu gugaccacga ugaugacaac     2700

gauggcauuc cugaugacaa ggacaacugc agacucgugc ccaaucccga ccagaaggac     2760

ucugacggcg auggucgagg ugaugccugc aaagaugauu uugaccauga cagugugcca     2820

gacaucgaug acaucugucc ugagaauguu gacaucagug agaccgauuu ccgccgauuc     2880

cagaugauuc cucuggaccc caaagggaca ucccaaaaug acccuaacug gguuguacgc     2940

caucagggua aagaacucgu ccagacuguc aacugugauc cuggacucgc uguagguuau     3000

gaugaguuua augcugugga cuucaguggc accuucuuca ucaacaccga aagggacgau     3060

gacuaugcug gauuugucuu uggcuaccag uccagcagcc gcuuuuaugu ugugaugugg     3120

aagcaaguca cccaguccua cugggacacc aaccccacga gggcucaggg auacucgggc     3180

cuuucuguga aaguuguaaa cuccaccaca gggccuggcg agcaccugcg gaacgcccug     3240

uggcacacag gaaacacccc uggccaggug cgcacccugu ggcaugaccc ucgucacaua     3300

ggcuggaaag auuucaccgc cuacagaugg cgucucagcc acaggccaaa gacggguuuc     3360

auuagagugg ugauguauga agggaagaaa aucauggcug acucaggacc caucuaugau     3420

aaaaccuaug cuggugguag acuaggguug uuugucuucu cucaagaaau gguguucuuc     3480

ucugaccuga aauacgaaug uagagauccc uaa                                  3513


<210>  7539
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7539
augggccugg ccugggggcu cggcgugcug uuccugaugc acgucugcgg gaccaaccgc       60

auccccgaga gcggcgggga caacuccgug uucgacaucu ucgagcucac cggcgccgcg      120

cggaagggca gcgggcgccg gcuggugaag ggcccggacc ccuccagccc cgccuuccgc      180

aucgaggacg ccaaccugau cccgcccguc cccgacgaca aguuccagga ccucguggac      240

gccgugcggg ccgagaaggg guuccugcug cucgcguccc ugcgccagau gaagaagacg      300

cggggcaccc ugcucgcccu ggagcgcaag gaccacagcg ggcaggucuu cuccguggug      360

agcaacggca aggccggcac ccuggaccuc ucccugaccg uccaggggaa gcagcacgug      420

gugagcgucg aggaggcccu gcucgcgacg ggccagugga aguccaucac ccuguucgug      480

caggaggacc gggcccagcu guacaucgac ugcgagaaga uggagaacgc cgagcucgac      540

gugcccaucc agagcgucuu cacccgcgac cuggccucca ucgcccggcu gcgcaucgcg      600

aagggcgggg ugaacgacaa cuuccagggc gugcuccaga acguccgguu cguguucggg      660

accacgcccg aggacauccu gcgcaacaag ggcugcagcu ccagcaccuc cgugcugcuc      720

acccuggaca acaacgucgu gaacgggagc uccccggcca uccggaccaa cuacaucggc      780

cacaagacga aggaccugca ggccaucugc gggaucagcu gcgacgagcu cagcuccaug      840

gugcuggagc ugcgcggccu ccggaccauc gucaccaccc ugcaggacag cauccgcaag      900

gugacggagg agaacaagga gcuggccaac gagcuccggc gcccgccccu gugcuaccac      960

aacggcgucc aguaccggaa caacgaggag uggaccgugg acuccugcac cgagugccac     1020

ugccagaaca gcgugaccau cugcaagaag gucuccugcc ccaucaugcc cugcagcaac     1080

gccacggugc ccgacgggga gugcugcccc cgcugcuggc ccuccgacag cgcggacgac     1140

ggcugguccc cguggagcga guggaccucc ugcagcaccu ccugcgggaa cggcauccag     1200

cagcgcgggc ggagcugcga cucccugaac aaccgcugcg agggcagcuc cgugcagacc     1260

cggacgugcc acauccagga gugcgacaag cgcuucaagc aggacggcgg guggagccac     1320

uggucccccu ggagcagcug cuccgugacc ugcggcgacg gggugaucac ccggauccgc     1380

cucugcaaca gccccagccc ccagaugaac ggcaagccgu gcgaggggga ggcccgggag     1440

accaaggccu gcaagaagga cgccugcccc aucaacggcg gcugggggcc cugguccccc     1500

ugggacaucu gcuccgugac gugcggcggg ggcguccaga agcgcagccg gcugugcaac     1560

aacccgacgc cccaguucgg cgggaaggac ugcgugggcg acgugaccga gaaccagauc     1620

ugcaacaagc aggacugccc caucgacggg ugccugucca accccugcuu cgccggcguc     1680

aagugcacca gcuacccgga cggguccugg aagugcggcg cgugcccgcc cggcuacagc     1740

gggaacggca uccagugcac cgacguggac gagugcaagg aggugcccga cgccugcuuc     1800

aaccacaacg gggagcaccg cugcgagaac accgaccccg gcuacaacug ccuccccugc     1860

ccgccccggu ucaccggguc ccagcccuuc ggccagggcg ucgagcacgc caccgccaac     1920

aagcaggucu gcaagccccg caaccccugc acggacggga cccacgacug caacaagaac     1980

gccaagugca acuaccuggg ccacuacagc gacccgaugu accggugcga gugcaagccc     2040

ggguacgcgg gcaacgggau caucugcggc gaggacaccg accuggacgg cuggcccaac     2100

gagaaccucg ugugcgucgc caacgccacc uaccacugca agaaggacaa cugccccaac     2160

cugccgaacu ccgggcagga ggacuacgac aaggacggca ucggggacgc cugcgacgac     2220

gacgacgaca acgacaagau ccccgacgac cgcgacaacu gccccuucca cuacaacccc     2280

gcgcaguacg acuacgaccg ggacgacgug ggcgaccgcu gcgacaacug cccguacaac     2340

cacaaccccg accaggccga caccgacaac aacggggagg gcgacgccug cgccgccgac     2400

aucgacggcg acgggauccu gaacgagcgg gacaacugcc aguacgugua caacgucgac     2460

cagcgcgaca cggacaugga cggcgugggg gaccagugcg acaacugccc ccucgagcac     2520

aaccccgacc agcuggacag cgacuccgac cggaucggcg acacgugcga caacaaccag     2580

gacaucgacg aggacggcca ccagaacaac cuggacaacu gcccguacgu gcccaacgcg     2640

aaccaggccg accacgacaa ggacgggaag ggcgacgccu gcgaccacga cgacgacaac     2700

gacgggaucc ccgacgacaa ggacaacugc cgccuggucc ccaacccgga ccagaaggac     2760

agcgacggcg acgggcgcgg cgacgccugc aaggacgacu ucgaccacga cuccgugccc     2820

gacaucgacg acaucugccc cgagaacgug gacaucagcg agaccgacuu ccggcgcuuc     2880

cagaugaucc cgcucgaccc caagggcacc agccagaacg accccaacug ggucgugcgg     2940

caccagggga aggagcuggu gcagaccguc aacugcgacc ccggccuggc cgugggguac     3000

gacgaguuca acgcggugga cuucuccggc accuucuuca ucaacaccga gcgcgacgac     3060

gacuacgccg gguucgucuu cggcuaccag agcuccagcc gguucuacgu ggugaugugg     3120

aagcagguca cccaguccua cugggacacg aacccgaccc gcgcccaggg cuacagcggg     3180

cucuccguga agguggucaa cagcaccacc ggccccgggg agcaccuccg gaacgcccug     3240

uggcacacgg gcaacacccc cggccaggug cgcacccugu ggcacgaccc ccggcacauc     3300

ggguggaagg acuucaccgc cuaccgcugg cggcuguccc accgcccgaa gacgggcuuc     3360

auccgggugg ucauguacga ggggaagaag aucauggcgg acagcggccc caucuacgac     3420

aagaccuacg ccgggggccg ccugggccuc uucguguucu cccaggagau gguguucuuc     3480

agcgaccuga aguacgagug ccgggacccc uga                                  3513


<210>  7540
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7540
augggccucg ccuggggccu cggcguccuc uuccucaugc acgucugcgg caccaaccgc       60

auccccgagu ccggcggcga caacuccguc uucgacaucu ucgagcucac cggcgccgcc      120

cgcaagggcu ccggccgccg ccucgucaag ggccccgacc ccuccucccc cgccuuccgc      180

aucgaggacg ccaaccucau cccccccguc cccgacgaca aguuccagga ccucgucgac      240

gccguccgcg ccgagaaggg cuuccuccuc cucgccuccc uccgccagau gaagaagacc      300

cgcggcaccc uccucgcccu cgagcgcaag gaccacuccg gccaggucuu cuccgucguc      360

uccaacggca aggccggcac ccucgaccuc ucccucaccg uccagggcaa gcagcacguc      420

gucuccgucg aggaggcccu ccucgccacc ggccagugga aguccaucac ccucuucguc      480

caggaggacc gcgcccagcu cuacaucgac ugcgagaaga uggagaacgc cgagcucgac      540

guccccaucc aguccgucuu cacccgcgac cucgccucca ucgcccgccu ccgcaucgcc      600

aagggcggcg ucaacgacaa cuuccagggc guccuccaga acguccgcuu cgucuucggc      660

accacccccg aggacauccu ccgcaacaag ggcugcuccu ccuccaccuc cguccuccuc      720

acccucgaca acaacgucgu caacggcucc ucccccgcca uccgcaccaa cuacaucggc      780

cacaagacca aggaccucca ggccaucugc ggcaucuccu gcgacgagcu cuccuccaug      840

guccucgagc uccgcggccu ccgcaccauc gucaccaccc uccaggacuc cauccgcaag      900

gucaccgagg agaacaagga gcucgccaac gagcuccgcc gccccccccu cugcuaccac      960

aacggcgucc aguaccgcaa caacgaggag uggaccgucg acuccugcac cgagugccac     1020

ugccagaacu ccgucaccau cugcaagaag gucuccugcc ccaucaugcc cugcuccaac     1080

gccaccgucc ccgacggcga gugcugcccc cgcugcuggc ccuccgacuc cgccgacgac     1140

ggcugguccc ccugguccga guggaccucc ugcuccaccu ccugcggcaa cggcauccag     1200

cagcgcggcc gcuccugcga cucccucaac aaccgcugcg agggcuccuc cguccagacc     1260

cgcaccugcc acauccagga gugcgacaag cgcuucaagc aggacggcgg cuggucccac     1320

uggucccccu gguccuccug cuccgucacc ugcggcgacg gcgucaucac ccgcauccgc     1380

cucugcaacu cccccucccc ccagaugaac ggcaagcccu gcgagggcga ggcccgcgag     1440

accaaggccu gcaagaagga cgccugcccc aucaacggcg gcuggggccc cugguccccc     1500

ugggacaucu gcuccgucac cugcggcggc ggcguccaga agcgcucccg ccucugcaac     1560

aaccccaccc cccaguucgg cggcaaggac ugcgucggcg acgucaccga gaaccagauc     1620

ugcaacaagc aggacugccc caucgacggc ugccucucca accccugcuu cgccggcguc     1680

aagugcaccu ccuaccccga cggcuccugg aagugcggcg ccugcccccc cggcuacucc     1740

ggcaacggca uccagugcac cgacgucgac gagugcaagg agguccccga cgccugcuuc     1800

aaccacaacg gcgagcaccg cugcgagaac accgaccccg gcuacaacug ccuccccugc     1860

cccccccgcu ucaccggcuc ccagcccuuc ggccagggcg ucgagcacgc caccgccaac     1920

aagcaggucu gcaagccccg caaccccugc accgacggca cccacgacug caacaagaac     1980

gccaagugca acuaccucgg ccacuacucc gaccccaugu accgcugcga gugcaagccc     2040

ggcuacgccg gcaacggcau caucugcggc gaggacaccg accucgacgg cuggcccaac     2100

gagaaccucg ucugcgucgc caacgccacc uaccacugca agaaggacaa cugccccaac     2160

cuccccaacu ccggccagga ggacuacgac aaggacggca ucggcgacgc cugcgacgac     2220

gacgacgaca acgacaagau ccccgacgac cgcgacaacu gccccuucca cuacaacccc     2280

gcccaguacg acuacgaccg cgacgacguc ggcgaccgcu gcgacaacug ccccuacaac     2340

cacaaccccg accaggccga caccgacaac aacggcgagg gcgacgccug cgccgccgac     2400

aucgacggcg acggcauccu caacgagcgc gacaacugcc aguacgucua caacgucgac     2460

cagcgcgaca ccgacaugga cggcgucggc gaccagugcg acaacugccc ccucgagcac     2520

aaccccgacc agcucgacuc cgacuccgac cgcaucggcg acaccugcga caacaaccag     2580

gacaucgacg aggacggcca ccagaacaac cucgacaacu gccccuacgu ccccaacgcc     2640

aaccaggccg accacgacaa ggacggcaag ggcgacgccu gcgaccacga cgacgacaac     2700

gacggcaucc ccgacgacaa ggacaacugc cgccucgucc ccaaccccga ccagaaggac     2760

uccgacggcg acggccgcgg cgacgccugc aaggacgacu ucgaccacga cuccgucccc     2820

gacaucgacg acaucugccc cgagaacguc gacaucuccg agaccgacuu ccgccgcuuc     2880

cagaugaucc cccucgaccc caagggcacc ucccagaacg accccaacug ggucguccgc     2940

caccagggca aggagcucgu ccagaccguc aacugcgacc ccggccucgc cgucggcuac     3000

gacgaguuca acgccgucga cuucuccggc accuucuuca ucaacaccga gcgcgacgac     3060

gacuacgccg gcuucgucuu cggcuaccag uccuccuccc gcuucuacgu cgucaugugg     3120

aagcagguca cccaguccua cugggacacc aaccccaccc gcgcccaggg cuacuccggc     3180

cucuccguca aggucgucaa cuccaccacc ggccccggcg agcaccuccg caacgcccuc     3240

uggcacaccg gcaacacccc cggccagguc cgcacccucu ggcacgaccc ccgccacauc     3300

ggcuggaagg acuucaccgc cuaccgcugg cgccucuccc accgccccaa gaccggcuuc     3360

auccgcgucg ucauguacga gggcaagaag aucauggccg acuccggccc caucuacgac     3420

aagaccuacg ccggcggccg ccucggccuc uucgucuucu cccaggagau ggucuucuuc     3480

uccgaccuca aguacgagug ccgcgacccc uga                                  3513


<210>  7541
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7541
augggccugg ccugggggcu cggagugcuu uuccugaugc acgucugcgg uaccaacaga       60

auccccgaga gcggcgggga caauuccguu uuugauauuu ucgaauugac aggagcugca      120

aggaagggcu cuggucggcg cuuagugaaa gggccugacc caucaagucc ggccuuucga      180

auagaggaug cgaaccugau ucccccugua ccagacgaua aguuccagga ccuaguggau      240

gcuguccgug ccgaaaaagg auuucuccug cuugcaagcc ugagacaaau gaagaaaacu      300

aggggcacgu ugcucgcccu ggagcggaag gaccauuccg gccagguguu cucuguugug      360

ucgaauggga aggcuggaac ccuggaucuc ucauuaacag uccaggguaa acagcacgug      420

guaagcguug aagaggcacu gcuugccacu ggccaaugga agaguaucac cuuguuugug      480

caggaggacc gcgcucagcu guacaucgau ugugaaaaga uggagaacgc cgaacuagac      540

guccccauuc aguccguguu cacaagagau cucgcgucua ucgcaaggcu gcggauagcc      600

aaagggggag ugaaugacaa cuuucaaggc guccuucaga auguucgcuu cguguuuggu      660

accacuccug aggacauccu gcgaaacaaa gggugcagcu ccucaacaag uguauugcuc      720

acccuggaua auaacguggu caauggaagc ucuccagcua uuagaacgaa cuauaucggc      780

cauaagacua aggacuuaca ggccauuugu ggcaucuccu gcgaugagcu gucaagcaug      840

gugcucgaac uuagggggcu gcggaccaua guuacaacuu ugcaggacag uauucguaaa      900

gugaccgagg aaaauaagga gcuagcaaac gaacugcgca gacccccucu cuguuaccac      960

aauggagucc aauauaggaa caacgaggag uggacagugg auucuugcac cgaaugucau     1020

ugccaaaauu ccguaacgau cuguaaaaag guuagcugcc caauuaugcc guguucgaac     1080

gcuacugugc ccgacgguga gugcugcccu cgguguuggc caucugauuc cgccgacgau     1140

ggcuggucac ccuggaguga auggacaagc ugcuccaccu cuugugggaa uggaauccag     1200

cagcgaggcc gcagcugcga cucacugaac aauagaugug aggguaguuc cguccagacu     1260

aggacaugcc acauccagga augugauaaa cgguucaagc aggacggggg cuggagccac     1320

uggucuccuu ggucaaguug cagcgugacc uguggagacg gcgucauuac gcgcauaaga     1380

cuuugcaacu ccccaucucc ccaaaugaau gggaaaccgu gugagggaga ggcgagggaa     1440

accaaggccu gcaagaaaga ugcaugcccu aucaacggug gcugggggcc cuggucgcca     1500

ugggacauuu guagcgugac augcggaggc gguguucaga agcguucccg gcuguguaau     1560

aacccuacuc cccaguuugg gggcaaagau ugcgugggag acguaaccga gaaucagauc     1620

uguaacaagc aagauugccc aauagacggc uguuugucaa aucccugcuu cgcugggguc     1680

aaauguacaa guuacccuga uggaucuugg aagugcggug ccuguccacc gggcuauagc     1740

gggaacggga uucagugcac ugacguggau gaaugcaagg agguucccga cgcuuguuuc     1800

aaucauaacg gcgaacaccg augcgagaac accgauccug guuacaauug ucucccaugu     1860

cccccuagau uuacaggguc ccagccauuc ggccagggag uggagcaugc caccgcaaac     1920

aaacaagucu gcaagcccag gaauccgugc acugacggca cgcacgauug uaacaaaaau     1980

gccaagugca acuaucuggg gcacuacuca gacccuaugu accgcuguga augcaaacca     2040

ggauaugcug gcaaugguau caucuguggg gaggacacag auuuagacgg auggcccaac     2100

gaaaaucugg ugugcguagc gaacgcaacc uaccauugca agaaggauaa uuguccuaac     2160

cuacccaaua gcggccagga ggacuaugau aaagacggua uuggcgaugc cugcgacgau     2220

gacgaugaca acgauaagau cccagacgac cgggauaauu guccuuuuca cuacaacccc     2280

gcucaguaug acuacgauag agacgaugug ggggacaggu gcgauaacug uccauauaau     2340

cauaacccgg accaggccga uacugacaau aacggagagg gcgaugcaug cgccgcugac     2400

auugacgggg auggaauacu caaugaacgc gacaacuguc aauacguuua caaugucgau     2460

cagcgagaca ccgauaugga cggcgugggu gaucagugcg acaacugucc ucuggagcac     2520

aaucccgauc aacuugacuc ugauuccgac cggaucgggg auacaugcga caacaaucag     2580

gacauugaug aagacggaca ucagaacaau uuggauaacu guccauaugu gcccaaugcc     2640

aaccaggcag accacgauaa agacggcaag ggugaugcgu gcgaccacga ugacgauaac     2700

gacggcaucc cugaugacaa agacaauugc cgucuggucc caaaccccga ucaaaaggac     2760

agugaugggg acggaagagg cgaugcuugu aaggacgauu ucgaccauga uagcguuccu     2820

gacaucgaug acauuugccc ggagaaugug gacauaucug aaaccgauuu uaggcgcuuc     2880

cagaugaucc cacucgaccc caaagggacu ucccagaacg auccuaauug ggugguacgg     2940

caccagggaa aggagcuggu ccaaacagug aacugugacc caggccuugc cguugguuac     3000

gaugaguuua augcagugga cuucucaggg acguuuuuca uuaacaccga aagagaugac     3060

gauuaugccg gauuugucuu cggcuaccag aguagcucga gguuuuaugu gguuaugugg     3120

aaacagguga cucaguccua cugggacaca aaucccaccc gagcucaagg uuauucuggc     3180

cugagcguaa aggucgugaa cucaacaacu gggccuggag agcauuugcg caaugcccuc     3240

uggcacaccg gcaacacgcc gggacaggug cggacccugu ggcacgaucc cagacauauc     3300

ggauggaaag acuucacagc auacaggugg cguuuaaguc accgcccaaa gacuggcuuc     3360

auucgggucg uuauguacga agguaaaaag aucauggcug auuccgggcc uauauaugac     3420

aagaccuacg ccggaggcag acugggccua uuuguguucu cucaggagau gguauuuuuc     3480

agcgaccuca aauaugaaug cagggauccc uga                                  3513


<210>  7542
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7542
augggccugg ccuggggccu gggcgugcug uuccugaugc acgugugcgg caccaacaga       60

auccccgaga gcggcggcga caacagcgug uucgacaucu ucgagcugac cggcgccgcc      120

agaaagggca gcggcagaag acuggugaag ggccccgacc ccagcagccc cgccuucaga      180

aucgaggacg ccaaccugau cccccccgug cccgacgaca aguuccagga ccugguggac      240

gccgugagag ccgagaaggg cuuccugcug cuggccagcc ugagacagau gaagaagacc      300

agaggcaccc ugcuggcccu ggagagaaag gaccacagcg gccagguguu cagcguggug      360

agcaacggca aggccggcac ccuggaccug agccugaccg ugcagggcaa gcagcacgug      420

gugagcgugg aggaggcccu gcuggccacc ggccagugga agagcaucac ccuguucgug      480

caggaggaca gagcccagcu guacaucgac ugcgagaaga uggagaacgc cgagcuggac      540

gugcccaucc agagcguguu caccagagac cuggccagca ucgccagacu gagaaucgcc      600

aagggcggcg ugaacgacaa cuuccagggc gugcugcaga acgugagauu cguguucggc      660

accacccccg aggacauccu gagaaacaag ggcugcagca gcagcaccag cgugcugcug      720

acccuggaca acaacguggu gaacggcagc agccccgcca ucagaaccaa cuacaucggc      780

cacaagacca aggaccugca ggccaucugc ggcaucagcu gcgacgagcu gagcagcaug      840

gugcuggagc ugagaggccu gagaaccauc gugaccaccc ugcaggacag caucagaaag      900

gugaccgagg agaacaagga gcuggccaac gagcugagaa gacccccccu gugcuaccac      960

aacggcgugc aguacagaaa caacgaggag uggaccgugg acagcugcac cgagugccac     1020

ugccagaaca gcgugaccau cugcaagaag gugagcugcc ccaucaugcc cugcagcaac     1080

gccaccgugc ccgacggcga gugcugcccc agaugcuggc ccagcgacag cgccgacgac     1140

ggcuggagcc ccuggagcga guggaccagc ugcagcacca gcugcggcaa cggcauccag     1200

cagagaggca gaagcugcga cagccugaac aacagaugcg agggcagcag cgugcagacc     1260

agaaccugcc acauccagga gugcgacaag agauucaagc aggacggcgg cuggagccac     1320

uggagccccu ggagcagcug cagcgugacc ugcggcgacg gcgugaucac cagaaucaga     1380

cugugcaaca gccccagccc ccagaugaac ggcaagcccu gcgagggcga ggccagagag     1440

accaaggccu gcaagaagga cgccugcccc aucaacggcg gcuggggccc cuggagcccc     1500

ugggacaucu gcagcgugac cugcggcggc ggcgugcaga agagaagcag acugugcaac     1560

aaccccaccc cccaguucgg cggcaaggac ugcgugggcg acgugaccga gaaccagauc     1620

ugcaacaagc aggacugccc caucgacggc ugccugagca accccugcuu cgccggcgug     1680

aagugcacca gcuaccccga cggcagcugg aagugcggcg ccugcccccc cggcuacagc     1740

ggcaacggca uccagugcac cgacguggac gagugcaagg aggugcccga cgccugcuuc     1800

aaccacaacg gcgagcacag augcgagaac accgaccccg gcuacaacug ccugcccugc     1860

ccccccagau ucaccggcag ccagcccuuc ggccagggcg uggagcacgc caccgccaac     1920

aagcaggugu gcaagcccag aaaccccugc accgacggca cccacgacug caacaagaac     1980

gccaagugca acuaccuggg ccacuacagc gaccccaugu acagaugcga gugcaagccc     2040

ggcuacgccg gcaacggcau caucugcggc gaggacaccg accuggacgg cuggcccaac     2100

gagaaccugg ugugcguggc caacgccacc uaccacugca agaaggacaa cugccccaac     2160

cugcccaaca gcggccagga ggacuacgac aaggacggca ucggcgacgc cugcgacgac     2220

gacgacgaca acgacaagau ccccgacgac agagacaacu gccccuucca cuacaacccc     2280

gcccaguacg acuacgacag agacgacgug ggcgacagau gcgacaacug ccccuacaac     2340

cacaaccccg accaggccga caccgacaac aacggcgagg gcgacgccug cgccgccgac     2400

aucgacggcg acggcauccu gaacgagaga gacaacugcc aguacgugua caacguggac     2460

cagagagaca ccgacaugga cggcgugggc gaccagugcg acaacugccc ccuggagcac     2520

aaccccgacc agcuggacag cgacagcgac agaaucggcg acaccugcga caacaaccag     2580

gacaucgacg aggacggcca ccagaacaac cuggacaacu gccccuacgu gcccaacgcc     2640

aaccaggccg accacgacaa ggacggcaag ggcgacgccu gcgaccacga cgacgacaac     2700

gacggcaucc ccgacgacaa ggacaacugc agacuggugc ccaaccccga ccagaaggac     2760

agcgacggcg acggcagagg cgacgccugc aaggacgacu ucgaccacga cagcgugccc     2820

gacaucgacg acaucugccc cgagaacgug gacaucagcg agaccgacuu cagaagauuc     2880

cagaugaucc cccuggaccc caagggcacc agccagaacg accccaacug gguggugaga     2940

caccagggca aggagcuggu gcagaccgug aacugcgacc ccggccuggc cgugggcuac     3000

gacgaguuca acgccgugga cuucagcggc accuucuuca ucaacaccga gagagacgac     3060

gacuacgccg gcuucguguu cggcuaccag agcagcagca gauucuacgu ggugaugugg     3120

aagcagguga cccagagcua cugggacacc aaccccacca gagcccaggg cuacagcggc     3180

cugagcguga agguggugaa cagcaccacc ggccccggcg agcaccugag aaacgcccug     3240

uggcacaccg gcaacacccc cggccaggug agaacccugu ggcacgaccc cagacacauc     3300

ggcuggaagg acuucaccgc cuacagaugg agacugagcc acagacccaa gaccggcuuc     3360

aucagagugg ugauguacga gggcaagaag aucauggccg acagcggccc caucuacgac     3420

aagaccuacg ccggcggcag acugggccug uucguguuca gccaggagau gguguucuuc     3480

agcgaccuga aguacgagug cagagacccc uga                                  3513


<210>  7543
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7543
augggccugg ccugggggcu cggagugcug uuccuuaugc acgucugcgg caccaacaga       60

auccccgaga gcgggggaga caauuccguu uuugauauuu ucgaacugac aggcgcugcc      120

cggaaggggu cuggacgcag acucgugaaa ggcccugacc cgagcucccc cgcguuucgg      180

aucgaggaug cuaaccugau uccucccgug ccugacgaua aguuccagga ccuugucgau      240

gccgugcgcg ccgaaaaagg cuuucugcuc cuggcuucuc ugagacaaau gaagaaaacg      300

cgggggaccc uccuggcccu ugagcgcaag gaccauagcg gacagguuuu cuccgugguc      360

ucuaauggca aggcugggac acuggaucuc agccugaccg ugcagggaaa acagcacguu      420

guguccgucg aagaggcccu ucuggcgaca ggccaaugga aaagcaucac ccucuuugug      480

caggaggaca gagcccagcu guacauugau ugugaaaaga uggagaacgc ugaacuggac      540

gugcccaucc agucugucuu cacacgggau cucgccucca ucgcucgccu gagaauugcc      600

aaagggggag uuaaugacaa cuuucaaggc gugcuucaga augugcgguu cgucuuuggc      660

accacgccug aggacauccu gcgcaacaag gggugcuccu cuuccaccag cgugcuccug      720

acacuugaua auaacguugu gaauggaucu uccccggcga uuagaaccaa cuauaucggc      780

cauaagacaa aggaccugca ggccauuugu gggaucagcu gcgaugagcu cuccucuaug      840

guccuggaac ugcggggacu ccgcaccauu gugacgacac ugcaggacag caucagaaaa      900

guuaccgagg aaaauaagga gcuugcuaac gaacugcgga gacccccucu cuguuaccac      960

aauggcgugc aauaucgcaa caacgaggag uggacagucg auuccugcac cgaaugucau     1020

ugccagaaua gcgugaccau cuguaaaaag gucucuugcc ccauuaugcc uuguuccaac     1080

gccacagugc ccgacgggga gugcugcccg cgguguuggc cuagcgauuc ugcugacgau     1140

ggauggagcc ccugguccga auggacgucu ugcagcaccu ccuguggcaa uggcauccag     1200

caaagagggc gcagcugcga cucucugaac aaucggugug agggauccag cguucagaca     1260

agaaccugcc acauucagga augugauaaa cgcuucaagc aggacggcgg guggucucac     1320

ugguccccuu ggagcuccug cucugugaca uguggagacg gcgucaucac ccggauuaga     1380

cuuugcaaca gccccagccc ccaaaugaau gggaaaccuu gugagggcga ggcccgcgaa     1440

acgaaggccu gcaagaaaga ugcuugcccg aucaacggag gcugggggcc cuggucuccu     1500

ugggacaucu guagcgugac augcggaggc gggguucaga agcgguccag acuguguaau     1560

aaccccaccc cucaguuugg aggcaaagau ugcguggggg acgucaccga gaaucagauu     1620

uguaacaagc aagauugccc caucgacggc ugucucagca auccgugcuu cgcgggagug     1680

aaauguacau cuuacccuga uggcuccugg aagugcgggg ccuguccccc uggauauagc     1740

ggcaacggga uucagugcac cgacguggau gaaugcaagg agguucccga cgcuuguuuc     1800

aaucauaacg gagaacaccg cugcgagaac acagauccug gcuacaauug ucugcccugc     1860

ccgccucggu uuacgggguc ucagcccuuc ggccagggag ucgagcaugc caccgccaac     1920

aaacaagugu guaagcccag aaauccuugc acagacggca cccacgauug uaacaaaaau     1980

gcuaagugca acuaucuggg gcacuacucc gacccgaugu accgguguga augcaaaccc     2040

ggauaugccg gcaaugggau cauuugugga gaggacacag aucucgacgg cuggccuaac     2100

gaaaaucugg ugugcgucgc gaacgcuacc uaccauugca agaaggauaa uugucccaac     2160

cuuccuaaua gcgggcagga ggacuaugau aaagacggca ucggagaugc cugcgacgau     2220

gacgaugaca acgauaagau ccccgacgac cgcgauaauu guccuuuuca cuacaacccc     2280

gcccaguaug acuacgauag agacgaugug ggcgaccggu gcgauaacug uccguauaau     2340

cauaacccug accaggcuga uacggacaau aacggggagg gagaugccug cgcugccgac     2400

auugacggcg augggauccu gaaugaaaga gacaacuguc aauacguuua caauguggau     2460

cagcgcgaca ccgauaugga cggagucggc gaucagugcg acaacugucc ccucgagcac     2520

aauccugauc aacuggacuc ugauagcgac cggauuggcg auacaugcga caacaaucag     2580

gacaucgaug aagacgggca ucagaacaau cuggauaacu gucccuaugu gccgaaugcg     2640

aaccaggccg accacgauaa agacggaaag ggcgaugcuu gcgaccacga ugacgauaac     2700

gacgggauuc cugaugacaa agacaauugc agacuuguuc ccaacccuga ucaaaaggac     2760

uccgauggag acggccgcgg ggaugccugu aaggacgauu ucgaccauga uagcgugccc     2820

gacaucgaug acauuugccc cgagaauguc gacaucucug aaaccgauuu uagacgguuc     2880

cagaugaucc cucucgaccc gaaaggaaca ucccagaacg aucccaauug ggugguucgc     2940

caccagggca aggagcuggu gcaaaccguc aacugugacc cuggccuggc ugugggguac     3000

gaugaguuua augccgugga cuucagcgga acguuuuuca uuaacacaga aagagaugac     3060

gauuaugcgg gcuuugucuu cggguaccag uccucuagcc gguuuuaugu ugugaugugg     3120

aaacagguga cccaguccua cugggacaca aaucccaccc gcgcccaagg auauucuggc     3180

cucagcguca aggugguuaa cuccaccaca gggccuggag agcaucugag aaaugcucuu     3240

uggcacacgg gcaacacccc cggccaggug cggacacugu ggcacgaucc ucgccauauc     3300

ggguggaaag acuucaccgc cuacagaugg cggcucucuc accgcccgaa gacaggauuc     3360

auuagagucg ugauguacga aggcaaaaag aucauggcug auagcgggcc cauuuaugac     3420

aagaccuacg ccggaggccg gcuggggcug uuuguuuucu cccaggagau gguguuuuuc     3480

agcgaccuua aauaugaaug cagagauccu uga                                  3513


<210>  7544
<211>  3513
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TSP-1__Homo_sapiens__AAI36470

<400>  7544
auggguuuag cuuggggucu agguguauua uuuuugaugc auguaugugg aacaaauaga       60

auaccagaau cgggaggaga uaauucagua uucgacauau uugaauuaac aggagcagca      120

agaaaaggca gcggaagaag acuuguuaag ggaccugacc caaguagucc cgcauuucgu      180

auagaggaug cuaaucuaau uccaccagua ccagaugaua aauuucaaga uuuagucgau      240

gcaguuagag cugaaaaagg uuucuuauua uuagcaagcu uaagacaaau gaagaaaaca      300

agagguacau uacuggcauu ggaaaggaaa gaccacagcg ggcaaguauu cucaguagua      360

ucuaauggaa aggccggaac uuuagauuua aguuugacag uccaaggaaa gcaacacgua      420

guaucgguug aagaggcccu auuagcuaca ggacagugga aaucgaucac auuauuugua      480

caagaagauc gagcacaauu auauauagau ugugaaaaaa uggaaaacgc agaauuggac      540

gucccaauuc aaucuguauu uacacgagau uuggcaucca ucgcaagacu acgaauagcu      600

aagggaggag uuaacgauaa cuuccaaggu guacuacaaa auguuagauu uguauucggg      660

acaacaccag aagacauuuu aaggaauaaa gguugcucaa guaguacuag uguauuauua      720

acguuggaua acaacguagu aaacgggagu ucacccgcua uucgaacuaa uuauaucgga      780

cacaaaacca aagacuuaca agcaauuugu gguauaucau gcgaugaauu gagcucgaug      840

guauuggaac ucagagguuu acgaacaauc guuacaacac uucaagauag cauaagaaaa      900

guaacagaag aaaacaaaga acuagcaaau gaacuccgac gaccaccguu augcuaccau      960

aacggcguac aauauagaaa caacgaagaa uggacuguug auucauguac ggaaugucac     1020

ugucaaaauu cuguaacaau auguaagaaa guaucguguc caauuaugcc auguucuaau     1080

gcuacaguuc ccgacggaga auguugcccc cgauguuggc caagugauuc agcagaugau     1140

ggcuggucgc cauggagcga auggacaagc ugcucaacau cuugugguaa ugguauacaa     1200

caacguggaa gaucauguga uucuuuaaau aaucguugcg aaggaaguuc ugugcaaacu     1260

cguacauguc auauccaaga augugauaaa cgcuucaaac aagacggagg auggucucac     1320

uggaguccau ggagcucaug cagcguaaca uguggagacg gcguaauuac cagaauuagg     1380

cuauguaaua guccaagccc gcaaaugaau gggaaacccu gugaaggaga agcaagagaa     1440

acaaaagcuu guaaaaaaga ugccugucca auaaaugggg gauggggacc guggucacca     1500

ugggacauau gcucggucac augcggcgga gggguccaaa aaaggucuag gcuaugcaac     1560

aauccaacac cacaauuugg aggaaaagau ugugucggag auguaaccga aaaucaaaua     1620

uguaacaagc aagauugucc aauagaugga uguuuaucaa auccaugcuu ugcaggagua     1680

aagugcacuu cauauccaga cggaaguugg aaauguggag cuugcccucc aggauauuca     1740

ggaaacggua uucaaugcac agauguagac gaauguaaag aaguaccuga cgcauguuuc     1800

aaucacaaug gagaacacag augcgagaau accgauccug gguauaacug ucuaccaugu     1860

ccaccaagau ucacuggaag ucagccuuuu ggacaaggag uagaacaugc gacagcaaac     1920

aaacagguau guaaaccuag aaacccgugc acggacggaa cacaugauug caauaaaaac     1980

gcgaaaugua auuacuuagg ucauuauucu gauccuaugu acagauguga augcaaaccu     2040

ggauaugcag gaaacgguau aauauguggc gaagacacag auuuagaugg uuggccaaac     2100

gaaaacuugg uauguguggc aaaugcgaca uaucauugua aaaaagauaa cugcccaaau     2160

cuaccuaaua gcggucaaga agacuaugac aaagauggua uaggagacgc cugugaugac     2220

gacgacgaua augauaaaau accugacgau cgggauaacu guccauucca cuacaauccc     2280

gcucaauaug auuaugacag ggaugacgua ggggaucgau gugauaacug uccauacaac     2340

cauaacccag aucaagcaga uacugauaac aacggugaag gugaugcaug ugcagcagau     2400

auagauggag acgguauauu aaacgagcga gacaauuguc aguacguuua uaacguugac     2460

caaagagaua cagacaugga ugguguagga gaucaaugug auaacugucc ccuagaacac     2520

aauccagacc aacuugacag ugauagugac cggauuggcg acacauguga uaacaaccaa     2580

gauauagaug aagauggaca ucaaaauaac cuagauaauu guccguacgu accaaaugca     2640

aaucaagcag aucaugauaa agaugguaaa ggagacgcuu gugaccauga ugaugauaac     2700

gauggcauuc cugaugauaa agacaauugc agacuaguac caaaucccga ucaaaaagau     2760

agcgauggag acgggagagg ugaugcuugc aaagaugauu uugaccauga cucaguucca     2820

gauauagaug auauuugucc agaaaauguu gacauaucug aaacagauuu ucgaagauuc     2880

caaaugauac cgcuagaccc aaaaggaacu ucacaaaaug auccaaauug gguaguaaga     2940

caucaaggaa aagagcuagu acaaacagua aauugcgauc cagggcuagc uguaggguau     3000

gacgaauuua augcaguaga uuucucagga accuuuuuua ucaauacuga aagagaugac     3060

gauuaugcug gauuuguauu uggcuaucag ucaagcagca gauuuuacgu aguaaugugg     3120

aaacaaguua cucaaagcua uugggauaca aauccaacaa gagcacaagg auacucagga     3180

cuuagcguaa aaguuguaaa cucaacaaca gguccaggag aacaccucag aaaugcacuu     3240

uggcauacag guaauacacc gggucaagug agaacacuuu ggcacgaucc uagacauaua     3300

ggauggaaag auuucacagc auaccgaugg cgauuaucac acagaccaaa gacaggauuu     3360

auaagaguag uaauguauga gggaaagaaa auaauggcag auuccggacc aauauaugau     3420

aagaccuaug ccggaggaag auuaggauua uuuguauuca gccaagaaau gguauucuuc     3480

agcgacuuga aauaugaaug uagagaucca uaa                                  3513


<210>  7545
<211>  1172
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TSP-2__Homo_sapiens__P35442

<400>  7545

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val Gly Phe Asp Glu Phe Gly Ser Val 
        995                 1000                1005            


Asp Phe Ser Gly Thr Phe Tyr Val Asn Thr Asp Arg Asp Asp Asp Tyr 
    1010                1015                1020                


Ala Gly Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val 
1025                1030                1035                1040


Met Trp Lys Gln Val Thr Gln Thr Tyr Trp Glu Asp Gln Pro Thr Arg 
                1045                1050                1055    


Ala Tyr Gly Tyr Ser Gly Val Ser Leu Lys Val Val Asn Ser Thr Thr 
            1060                1065                1070        


Gly Thr Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr 
        1075                1080                1085            


Pro Gly Gln Val Arg Thr Leu Trp His Asp Pro Arg Asn Ile Gly Trp 
    1090                1095                1100                


Lys Asp Tyr Thr Ala Tyr Arg Trp His Leu Thr His Arg Pro Lys Thr 
1105                1110                1115                1120


Gly Tyr Ile Arg Val Leu Val His Glu Gly Lys Gln Val Met Ala Asp 
                1125                1130                1135    


Ser Gly Pro Ile Tyr Asp Gln Thr Tyr Ala Gly Gly Arg Leu Gly Leu 
            1140                1145                1150        


Phe Val Phe Ser Gln Glu Met Val Tyr Phe Ser Asp Leu Lys Tyr Glu 
        1155                1160                1165            


Cys Arg Asp Ile 
    1170        


<210>  7546
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TSP-2__Homo_sapiens__BAF85118

<400>  7546
auggucugga ggcugguccu gcuggcucug uggguguggc ccagcacgca agcuggucac       60

caggacaaag acacgaccuu cgaccuuuuc aguaucagca acaucaaccg caagaccauu      120

ggcgccaagc aguuccgcgg gcccgacccc ggcgugccgg cuuaccgcuu cgugcgcuuu      180

gacuacaucc caccggugaa cgcagaugac cucagcaaga ucaccaagau caugcggcag      240

aaggagggcu ucuuccucac ggcccagcuc aagcaggacg gcaaguccag gggcacgcug      300

uuggcucugg agggccccgg ucucucccag aggcaguucg agaucgucuc caauggcccc      360

gcggacacgc uggaucucac cuacuggauu gacggcaccc ggcauguggu cucccuggag      420

gacgucggcc uggcugacuc gcaguggaag aacgucaccg ugcagguggc uggcgagacc      480

uacagcuugc acgugggcug cgaccucaua gacagcuucg cucuggacga gcccuucuac      540

gagcaccugc aggcggaaaa gagccggaug uacguggcca aaggcucugc cagagagagu      600

cacuucaggg guuugcuuca gaacguccac cuaguguuug aaaacucugu ggaagauauu      660

cuaagcaaga aggguugcca gcaaggccag ggagcugaga ucaacgccau cagugagaac      720

acagagacgc ugcgccuggg uccgcauguc accaccgagu acgugggccc cagcucggag      780

aggaggcccg aggugugcga acgcucgugc gaggagcugg gaaacauggu ccaggagcuc      840

ucggggcucc acguccucgu gaaccagcuc agcgagaacc ucaagagagu gucgaaugau      900

aaccaguuuc ucugggagcu cauugguggc ccuccuaaga caaggaacau gucagcuugc      960

uggcaggaug gccgguucuu ugcggaaaau gaaacguggg ugguggacag cugcaccacg     1020

uguaccugca agaaauuuaa aaccauuugc caccaaauca ccugcccgcc ugcaaccugc     1080

gccaguccau ccuuugugga aggcgaaugc ugcccuuccu gccuccacuc gguggacggu     1140

gaggagggcu ggucuccgug ggcagagugg acccagugcu ccgugacgug uggcucuggg     1200

acccagcaga gaggccgguc cugugacguc accagcaaca ccugcuuggg gcccuccauc     1260

cagacacggg cuugcagucu gagcaagugu gacacccgca uccggcagga cggcggcugg     1320

agccacuggu caccuugguc uucaugcucu gugaccugug gaguuggcaa uaucacacgc     1380

auccgucucu gcaacucccc agugccccag auggggggca agaauugcaa agggaguggc     1440

cgggagacca aagccugcca gggcgcccca ugcccaaucg auggccgcug gagccccugg     1500

uccccguggu cggccugcac ugucaccugu gccgguggga uccgggagcg cacccggguc     1560

ugcaacagcc cugagccuca guacggaggg aaggccugcg ugggggaugu gcaggagcgu     1620

cagaugugca acaagaggag cugccccgug gauggcuguu uauccaaccc cugcuucccg     1680

ggagcccagu gcagcagcuu ccccgauggg uccuggucau gcggcuccug cccugugggc     1740

uucuugggca auggcaccca cugugaggac cuggacgagu gugcccuggu ccccgacauc     1800

ugcuucucca ccagcaaggu gccucgcugu gucaacacuc agccuggcuu ccacugccug     1860

cccugcccgc cccgauacag agggaaccag cccgucgggg ucggccugga agcagccaag     1920

acggaaaagc aaguguguga gcccgaaaac ccaugcaagg acaagacaca caacugccac     1980

aagcacgcgg agugcaucua ccugggccac uucagcgacc ccauguacaa gugcgagugc     2040

cagacaggcu acgcgggcga cgggcucauc ugcggggagg acucggaccu ggacggcugg     2100

cccaaccuca aucuggucug cgccaccaac gccaccuacc acugcaucaa ggauaacugc     2160

ccccaucugc caaauucugg gcaggaagac uuugacaagg acgggauugg cgaugccugu     2220

gaugaugacg augacaauga cggugugacc gaugagaagg acaacugcca gcuccucuuc     2280

aauccccgcc aggcugacua ugacaaggau gagguugggg accgcuguga caacugcccu     2340

uacgugcaca acccugccca gaucgacaca gacaacaaug gagaggguga cgccugcucc     2400

guggacauug auggggacga ugucuucaau gaacgagaca auugucccua cgucuacaac     2460

acugaccaga gggacacgga uggugacggu gugggggauc acugugacaa cugcccccug     2520

gugcacaacc cugaccagac cgacguggac aaugaccuug uuggggacca gugugacaac     2580

aacgaggaca uagaugacga cggccaccag aacaaccagg acaacugccc cuacaucucc     2640

aacgccaacc aggcugacca ugacagagac ggccagggcg acgccuguga cccugaugau     2700

gacaacgaug gcguccccga ugacagggac aacugccggc uuguguucaa cccagaccag     2760

gaggacuugg acggugaugg acggggugau auuuguaaag augauuuuga caaugacaac     2820

aucccagaua uugaugaugu guguccugaa aacaaugcca ucagugagac agacuucagg     2880

aacuuccaga ugguccccuu ggaucccaaa gggaccaccc aaauugaucc caacuggguc     2940

auucgccauc aaggcaagga gcugguucag acagccaacu cggaccccgg caucgcugua     3000

gguuuugacg aguuuggguc uguggacuuc aguggcacau ucuacguaaa cacugaccgg     3060

gacgacgacu augccggcuu cgucuuuggu uaccagucaa gcagccgcuu cuauguggug     3120

auguggaagc aggugacgca gaccuacugg gaggaccagc ccacgcgggc cuauggcuac     3180

uccggcgugu cccucaaggu ggugaacucc accacgggga cgggcgagca ccugaggaac     3240

gcgcuguggc acacggggaa cacgccgggg caggugcgaa ccuuauggca cgaccccagg     3300

aacauuggcu ggaaggacua cacggccuau agguggcacc ugacucacag gcccaagacu     3360

ggcuacauca gagucuuagu gcaugaagga aaacagguca uggcagacuc aggaccuauc     3420

uaugaccaaa ccuacgcugg cgggcggcug ggucuauuug ucuucucuca agaaaugguc     3480

uauuucucag accucaagua cgaaugcaga gauauuuaa                            3519


<210>  7547
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7547
augguguggc gccugguccu ccuggcccug uggguguggc ccagcaccca ggccggccac       60

caggacaagg acaccacguu cgaccucuuc uccaucagca acaucaaccg gaagaccauc      120

ggggcgaagc aguuccgcgg cccggacccc ggggugcccg ccuaccgguu cguccgcuuc      180

gacuacaucc cgcccgugaa cgccgacgac cuguccaaga ucaccaagau caugcggcag      240

aaggagggcu ucuuccugac cgcccagcuc aagcaggacg gcaagagccg cgggacgcug      300

cuggcccucg agggccccgg gcugucccag cggcaguucg agaucgugag caacggcccc      360

gcggacaccc uggaccucac cuacuggauc gacgggaccc gccacgucgu gucccuggag      420

gacgugggcc uggccgacag ccaguggaag aacgucacgg uccagguggc cggggagacc      480

uacucccucc acgugggcug cgaccugauc gacagcuucg cccuggacga gcccuucuac      540

gagcaccucc aggcggagaa gucccggaug uacguggcca agggcagcgc ccgcgagucc      600

cacuuccggg ggcugcugca gaacgugcac cucgucuucg agaacagcgu ggaggacauc      660

cuguccaaga agggcugcca gcaggggcag ggcgccgaga ucaacgccau cagcgagaac      720

accgagaccc ugcgccucgg cccgcacgug acgaccgagu acgucgggcc cuccagcgag      780

cggcgccccg aggugugcga gcgguccugc gaggagcugg gcaacauggu gcaggagcug      840

agcgggcucc acguccuggu gaaccagcug agcgagaacc ucaagcgcgu guccaacgac      900

aaccaguucc ugugggagcu gaucggcggg cccccgaaga cccggaacau gagcgcgugc      960

uggcaggacg gccgcuucuu cgccgagaac gagaccuggg ucguggacuc cugcacgacc     1020

ugcacgugca agaaguucaa gaccaucugc caccagauca cgugcccgcc cgcgaccugc     1080

gccagccccu ccuucgucga gggcgagugc ugccccagcu gccuccacuc cguggacggg     1140

gaggagggcu ggagccccug ggccgagugg acccagugcu ccgugaccug cgggagcggc     1200

acccagcagc gggggcgcuc cugcgacguc accagcaaca cgugccuggg ccccuccauc     1260

cagacccggg cgugcagccu guccaagugc gacacccgca uccgccagga cggcgggugg     1320

agccacuggu cccccuggag cuccugcagc gugaccugcg gcguggggaa caucacccgg     1380

auccgccucu gcaacagccc ggucccccag augggcggga agaacugcaa gggcuccggc     1440

cgggagacca aggccugcca gggggccccc ugccccaucg acggccgcug gagcccgugg     1500

ucccccugga gcgccugcac ggugaccugc gccgggggca uccgggagcg cacccgggug     1560

ugcaacuccc ccgagcccca guacggcggg aaggcgugcg ucggcgacgu gcaggagcgc     1620

cagaugugca acaagcggag cugcccggug gacgggugcc uguccaaccc cugcuucccc     1680

ggcgcccagu gcagcuccuu cccggacggg agcugguccu gcggcagcug ccccgucggc     1740

uuccugggga acggcaccca cugcgaggac cucgacgagu gcgcccuggu gcccgacauc     1800

ugcuucucca cgagcaaggu gccccgcugc gucaacaccc agccgggguu ccacugccug     1860

cccugcccgc cccgguaccg cggcaaccag cccguggggg ugggccucga ggccgccaag     1920

accgagaagc aggucugcga gcccgagaac cccugcaagg acaagaccca caacugccac     1980

aagcacgcgg agugcaucua ccugggccac uucuccgacc ccauguacaa gugcgagugc     2040

cagaccgggu acgccggcga cgggcugauc ugcggcgagg acagcgaccu cgacgggugg     2100

ccgaaccuga accuggugug cgccacgaac gccaccuacc acugcaucaa ggacaacugc     2160

ccccaccucc ccaacuccgg ccaggaggac uucgacaagg acggcaucgg ggacgcgugc     2220

gacgacgacg acgacaacga cggcgugacc gacgagaagg acaacugcca gcugcuguuc     2280

aacccccggc aggccgacua cgacaaggac gaggucgggg accgcugcga caacugcccg     2340

uacgugcaca accccgccca gaucgacacc gacaacaacg gcgaggggga cgccugcagc     2400

guggacaucg acggcgacga cgucuucaac gagcgggaca acugccccua cguguacaac     2460

acggaccagc gcgacaccga cggcgacggg gugggcgacc acugcgacaa cugcccccug     2520

guccacaacc cggaccagac cgacguggac aacgaccucg ugggggacca gugcgacaac     2580

aacgaggaca ucgacgacga cggccaccag aacaaccagg acaacugccc cuacaucagc     2640

aacgccaacc aggcggacca cgaccgggac ggccaggggg acgccugcga ccccgacgac     2700

gacaacgacg gcguccccga cgaccgcgac aacugccggc ugguguucaa cccggaccag     2760

gaggaccugg acggggacgg ccgcggggac aucugcaagg acgacuucga caacgacaac     2820

auccccgaca ucgacgacgu gugccccgag aacaacgcca ucuccgagac cgacuuccgc     2880

aacuuccaga uggucccgcu cgaccccaag ggcacgaccc agaucgaccc caacugggug     2940

auccggcacc agggcaagga gcuggugcag accgccaaca gcgaccccgg gaucgccguc     3000

ggcuucgacg aguucggguc cguggacuuc agcggcaccu ucuacgugaa cacggaccgc     3060

gacgacgacu acgcgggguu cgucuucggc uaccagucca gcucccgguu cuacguggug     3120

auguggaagc aggucaccca gaccuacugg gaggaccagc cgacccgcgc cuacggcuac     3180

agcggggugu cccugaaggu ggucaacagc acgaccggca ccggggagca ccuccggaac     3240

gcccuguggc acaccggcaa cacgcccggc caggugcgca cccuguggca cgacccccgg     3300

aacaucgggu ggaaggacua caccgccuac cgcuggcacc ucacccaccg gcccaagacg     3360

ggcuacaucc gcgugcuggu ccacgagggg aagcagguca uggccgacuc cggcccgauc     3420

uacgaccaga ccuacgccgg gggccggcug ggccucuucg uguucagcca ggagauggug     3480

uacuucuccg accugaagua cgagugccgc gacaucuga                            3519


<210>  7548
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7548
auggucuggc gccucguccu ccucgcccuc ugggucuggc ccuccaccca ggccggccac       60

caggacaagg acaccaccuu cgaccucuuc uccaucucca acaucaaccg caagaccauc      120

ggcgccaagc aguuccgcgg ccccgacccc ggcguccccg ccuaccgcuu cguccgcuuc      180

gacuacaucc cccccgucaa cgccgacgac cucuccaaga ucaccaagau caugcgccag      240

aaggagggcu ucuuccucac cgcccagcuc aagcaggacg gcaagucccg cggcacccuc      300

cucgcccucg agggccccgg ccucucccag cgccaguucg agaucgucuc caacggcccc      360

gccgacaccc ucgaccucac cuacuggauc gacggcaccc gccacgucgu cucccucgag      420

gacgucggcc ucgccgacuc ccaguggaag aacgucaccg uccaggucgc cggcgagacc      480

uacucccucc acgucggcug cgaccucauc gacuccuucg cccucgacga gcccuucuac      540

gagcaccucc aggccgagaa gucccgcaug uacgucgcca agggcuccgc ccgcgagucc      600

cacuuccgcg gccuccucca gaacguccac cucgucuucg agaacuccgu cgaggacauc      660

cucuccaaga agggcugcca gcagggccag ggcgccgaga ucaacgccau cuccgagaac      720

accgagaccc uccgccucgg cccccacguc accaccgagu acgucggccc cuccuccgag      780

cgccgccccg aggucugcga gcgcuccugc gaggagcucg gcaacauggu ccaggagcuc      840

uccggccucc acguccucgu caaccagcuc uccgagaacc ucaagcgcgu cuccaacgac      900

aaccaguucc ucugggagcu caucggcggc ccccccaaga cccgcaacau guccgccugc      960

uggcaggacg gccgcuucuu cgccgagaac gagaccuggg ucgucgacuc cugcaccacc     1020

ugcaccugca agaaguucaa gaccaucugc caccagauca ccugcccccc cgccaccugc     1080

gccucccccu ccuucgucga gggcgagugc ugccccuccu gccuccacuc cgucgacggc     1140

gaggagggcu ggucccccug ggccgagugg acccagugcu ccgucaccug cggcuccggc     1200

acccagcagc gcggccgcuc cugcgacguc accuccaaca ccugccucgg ccccuccauc     1260

cagacccgcg ccugcucccu cuccaagugc gacacccgca uccgccagga cggcggcugg     1320

ucccacuggu cccccugguc cuccugcucc gucaccugcg gcgucggcaa caucacccgc     1380

auccgccucu gcaacucccc cgucccccag augggcggca agaacugcaa gggcuccggc     1440

cgcgagacca aggccugcca gggcgccccc ugccccaucg acggccgcug gucccccugg     1500

ucccccuggu ccgccugcac cgucaccugc gccggcggca uccgcgagcg cacccgcguc     1560

ugcaacuccc ccgagcccca guacggcggc aaggccugcg ucggcgacgu ccaggagcgc     1620

cagaugugca acaagcgcuc cugccccguc gacggcugcc ucuccaaccc cugcuucccc     1680

ggcgcccagu gcuccuccuu ccccgacggc uccugguccu gcggcuccug ccccgucggc     1740

uuccucggca acggcaccca cugcgaggac cucgacgagu gcgcccucgu ccccgacauc     1800

ugcuucucca ccuccaaggu cccccgcugc gucaacaccc agcccggcuu ccacugccuc     1860

cccugccccc cccgcuaccg cggcaaccag cccgucggcg ucggccucga ggccgccaag     1920

accgagaagc aggucugcga gcccgagaac cccugcaagg acaagaccca caacugccac     1980

aagcacgccg agugcaucua ccucggccac uucuccgacc ccauguacaa gugcgagugc     2040

cagaccggcu acgccggcga cggccucauc ugcggcgagg acuccgaccu cgacggcugg     2100

cccaaccuca accucgucug cgccaccaac gccaccuacc acugcaucaa ggacaacugc     2160

ccccaccucc ccaacuccgg ccaggaggac uucgacaagg acggcaucgg cgacgccugc     2220

gacgacgacg acgacaacga cggcgucacc gacgagaagg acaacugcca gcuccucuuc     2280

aacccccgcc aggccgacua cgacaaggac gaggucggcg accgcugcga caacugcccc     2340

uacguccaca accccgccca gaucgacacc gacaacaacg gcgagggcga cgccugcucc     2400

gucgacaucg acggcgacga cgucuucaac gagcgcgaca acugccccua cgucuacaac     2460

accgaccagc gcgacaccga cggcgacggc gucggcgacc acugcgacaa cugcccccuc     2520

guccacaacc ccgaccagac cgacgucgac aacgaccucg ucggcgacca gugcgacaac     2580

aacgaggaca ucgacgacga cggccaccag aacaaccagg acaacugccc cuacaucucc     2640

aacgccaacc aggccgacca cgaccgcgac ggccagggcg acgccugcga ccccgacgac     2700

gacaacgacg gcguccccga cgaccgcgac aacugccgcc ucgucuucaa ccccgaccag     2760

gaggaccucg acggcgacgg ccgcggcgac aucugcaagg acgacuucga caacgacaac     2820

auccccgaca ucgacgacgu cugccccgag aacaacgcca ucuccgagac cgacuuccgc     2880

aacuuccaga uggucccccu cgaccccaag ggcaccaccc agaucgaccc caacuggguc     2940

auccgccacc agggcaagga gcucguccag accgccaacu ccgaccccgg caucgccguc     3000

ggcuucgacg aguucggcuc cgucgacuuc uccggcaccu ucuacgucaa caccgaccgc     3060

gacgacgacu acgccggcuu cgucuucggc uaccaguccu ccucccgcuu cuacgucguc     3120

auguggaagc aggucaccca gaccuacugg gaggaccagc ccacccgcgc cuacggcuac     3180

uccggcgucu cccucaaggu cgucaacucc accaccggca ccggcgagca ccuccgcaac     3240

gcccucuggc acaccggcaa cacccccggc cagguccgca cccucuggca cgacccccgc     3300

aacaucggcu ggaaggacua caccgccuac cgcuggcacc ucacccaccg ccccaagacc     3360

ggcuacaucc gcguccucgu ccacgagggc aagcagguca uggccgacuc cggccccauc     3420

uacgaccaga ccuacgccgg cggccgccuc ggccucuucg ucuucuccca ggagaugguc     3480

uacuucuccg accucaagua cgagugccgc gacaucuga                            3519


<210>  7549
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7549
auggugugga gacugguccu ccuugcccug uggguuuggc ccagcaccca ggcuggccac       60

caagacaagg auacaacuuu cgacuuguuu uccaucucua acauuaauag gaaaacgaua      120

ggggcaaagc aguuccgggg accugaucca ggugugccgg ccuaccgcuu uguacgauuc      180

gacuauaucc caccugugaa cgcggaugac uuaucaaaaa uuaccaagau caugcgucag      240

aaagagggcu uuuuccugac agcucagcua aagcaagaug ggaagaguag aggaacucuc      300

cuggcccuug aaggcccagg ucugagccag aggcaguuug agauugucuc caaugggccc      360

gcagacaccu uggaucucac auacuggauc gacggaaccc ggcauguggu uucucuggaa      420

gaugugggcc uggccgacuc gcaguggaaa aacgucacug ugcaaguagc uggcgagaca      480

uauucacucc acguugggug cgauuuaaua gacagcuucg cacuggacga accuuuuuac      540

gagcaucuuc aggccgagaa gagucgcaug uauguggcua aaggauccgc cagagaaucu      600

cacuucaggg guuugcugca gaauguccau cuaguguuug agaacagcgu ggaagauauc      660

cucuccaaga aaggcuguca gcaagggcag ggagcggaga uuaaugcaau cucagagaac      720

accgaaacgc ugcggcuugg cccacacguc acuaccgagu acguuggucc caguagcgaa      780

cgccgaccug aggugugcga aagaucuugu gaggagcugg ggaauauggu acaggaauug      840

uccggacucc acgugcuggu caaccaauua ucagagaauc ugaagagggu gagcaacgac      900

aaucaguucc ucugggaacu uauuggcggc ccaccgaaga cacggaacau gagugccugc      960

uggcaggaug ggcgcuuuuu cgcugagaau gaaacuuggg uuguggacuc uuguaccaca     1020

ugcaccugua aaaaguucaa aacgaucugc caucagauaa cuuguccccc ugccacaugc     1080

gcauccccca gcuuugucga gggagagugu ugccccucgu gccugcacuc uguggauggu     1140

gaagagggcu gguccccuug ggcugaaugg acccaauguu caguaacuug cgggagugga     1200

acacagcagc guggcagaag cugugacguu accuccaaca cgugcuuggg uccaucuauu     1260

cagaccaggg ccuguagccu aucaaagugc gauacacgga uccgacaaga cgggggcugg     1320

agucauuggu cccccuggag cucuuguuca gugacuugcg gagucggcaa cauuacccgc     1380

aucagacugu guaauagucc ggugccucag augggaggga aaaacugcaa ggguagcggc     1440

agggagacaa aagcguguca gggggccccc ugcccaaucg auggacggug guccccuugg     1500

ucucccuggu cggcaugcac ugucaccugu gcuggcggua uucgcgaaag aacaagggug     1560

ugcaauagcc cagagcccca guaugggggc aaggccugug uuggagacgu gcaagagcgu     1620

cagaugugca acaagcgguc cuguccugua gauggcugcc ucucaaaucc auguuucccg     1680

ggggcucagu gcaguucuuu ucccgacgga agcugguccu gugguucaug cccugucggc     1740

uuccugggga acggaaccca cugugaagac cuugaugagu gcgcccuggu gccagacaua     1800

ugcuuuagca cuucuaaagu uccccgaugu gugaauacgc agccuggcuu ccacugcuug     1860

ccaugucccc cgagauacag ggguaaccaa ccugucgggg ugggccucga agcagccaag     1920

acagagaaac agguaugcga gccagaaaau cccuguaagg auaaaaccca uaacugccac     1980

aagcaugcug aguguaucua ccugggacac uuuuccgacc cuauguauaa gugcgaaugu     2040

cagacuggcu acgcggggga uggauuaauu ugcggcgagg acagugaucu ggacgguugg     2100

cccaaucuaa accucgugug ugcaaccaau gccacauauc auugcaucaa agauaacugc     2160

ccacaucugc cuaauagcgg gcaagaagac uucgauaagg acggaauagg cgaugcuugu     2220

gacgacgaug acgauaacga cgguguuacc gaugagaaag acaacugcca gcuuuuguuu     2280

aauccccgcc aggccgauua cgacaaggau gaggucggcg accgguguga uaacugccca     2340

uaugugcaca auccggcaca gauugacacu gauaacaaug gggaaggaga cgccuguucu     2400

guggacaucg auggcgacga ugucuucaac gagagagaca auugcccuua cguuuauaac     2460

acagaucaaa gggacacgga uggggacgga gugggcgauc acugugacaa uugcccccug     2520

gugcacaacc cagaucagac cgacguagac aaugaucucg ucggugacca gugugauaac     2580

aaugaagaca ucgaugacga ugggcaucag aacaaucaag acaacugccc cuacauuucc     2640

aacgcuaauc aggccgauca cgaccgcgau ggacagggcg acgcauguga uccugacgac     2700

gauaacgacg gugugccaga ugaccgagau aauugccggc ugguuuuuaa ccccgaccag     2760

gaggaucuug acggcgaugg gcguggagac aucugcaaag augacuucga uaaugacaac     2820

auuccugaca uagaugacgu guguccggaa aauaacgcga ucucagagac ugauuuuaga     2880

aauuuccaaa uggucccacu ggaccccaag ggcacaaccc agauugaucc uaacugggug     2940

aucaggcacc aggggaagga guugguucaa acagcuaaua gugacccagg aaucgccgug     3000

ggcuucgaug aauuugguag cguagacuuc ucggggacuu uuuacgucaa caccgaucgc     3060

gacgaugacu augcaggauu cguguuuggc uaccaguccu cuagccgguu cuaugugguc     3120

auguggaaac agguuacgca gaccuacugg gaggaccaac ccacaagagc cuaugguuac     3180

ucaggcguga gucucaaggu agugaacucc acuaccggga caggagaaca ucugaggaau     3240

gcuuuauggc acacuggcaa uaccccuggg cagguccgaa cgcuguggca ugauccgcgc     3300

aacauuggau ggaaagacua uacagccuac cgguggcacc uaacccauag acccaagacu     3360

ggcuacauaa gggugcucgu ucacgagggu aaacagguga uggcagauuc ugggccaauc     3420

uaugaccaga cauacgcugg aggccgucug ggccuuuuug ucuucagcca agaaauggug     3480

uauuuuuccg auuugaagua cgagugccgc gacauuuga                            3519


<210>  7550
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7550
auggugugga gacuggugcu gcuggcccug uggguguggc ccagcaccca ggccggccac       60

caggacaagg acaccaccuu cgaccuguuc agcaucagca acaucaacag aaagaccauc      120

ggcgccaagc aguucagagg ccccgacccc ggcgugcccg ccuacagauu cgugagauuc      180

gacuacaucc cccccgugaa cgccgacgac cugagcaaga ucaccaagau caugagacag      240

aaggagggcu ucuuccugac cgcccagcug aagcaggacg gcaagagcag aggcacccug      300

cuggcccugg agggccccgg ccugagccag agacaguucg agaucgugag caacggcccc      360

gccgacaccc uggaccugac cuacuggauc gacggcacca gacacguggu gagccuggag      420

gacgugggcc uggccgacag ccaguggaag aacgugaccg ugcagguggc cggcgagacc      480

uacagccugc acgugggcug cgaccugauc gacagcuucg cccuggacga gcccuucuac      540

gagcaccugc aggccgagaa gagcagaaug uacguggcca agggcagcgc cagagagagc      600

cacuucagag gccugcugca gaacgugcac cugguguucg agaacagcgu ggaggacauc      660

cugagcaaga agggcugcca gcagggccag ggcgccgaga ucaacgccau cagcgagaac      720

accgagaccc ugagacuggg cccccacgug accaccgagu acgugggccc cagcagcgag      780

agaagacccg aggugugcga gagaagcugc gaggagcugg gcaacauggu gcaggagcug      840

agcggccugc acgugcuggu gaaccagcug agcgagaacc ugaagagagu gagcaacgac      900

aaccaguucc ugugggagcu gaucggcggc ccccccaaga ccagaaacau gagcgccugc      960

uggcaggacg gcagauucuu cgccgagaac gagaccuggg ugguggacag cugcaccacc     1020

ugcaccugca agaaguucaa gaccaucugc caccagauca ccugcccccc cgccaccugc     1080

gccagcccca gcuucgugga gggcgagugc ugccccagcu gccugcacag cguggacggc     1140

gaggagggcu ggagccccug ggccgagugg acccagugca gcgugaccug cggcagcggc     1200

acccagcaga gaggcagaag cugcgacgug accagcaaca ccugccuggg ccccagcauc     1260

cagaccagag ccugcagccu gagcaagugc gacaccagaa ucagacagga cggcggcugg     1320

agccacugga gccccuggag cagcugcagc gugaccugcg gcgugggcaa caucaccaga     1380

aucagacugu gcaacagccc cgugccccag augggcggca agaacugcaa gggcagcggc     1440

agagagacca aggccugcca gggcgccccc ugccccaucg acggcagaug gagccccugg     1500

agccccugga gcgccugcac cgugaccugc gccggcggca ucagagagag aaccagagug     1560

ugcaacagcc ccgagcccca guacggcggc aaggccugcg ugggcgacgu gcaggagaga     1620

cagaugugca acaagagaag cugccccgug gacggcugcc ugagcaaccc cugcuucccc     1680

ggcgcccagu gcagcagcuu ccccgacggc agcuggagcu gcggcagcug ccccgugggc     1740

uuccugggca acggcaccca cugcgaggac cuggacgagu gcgcccuggu gcccgacauc     1800

ugcuucagca ccagcaaggu gcccagaugc gugaacaccc agcccggcuu ccacugccug     1860

cccugccccc ccagauacag aggcaaccag cccgugggcg ugggccugga ggccgccaag     1920

accgagaagc aggugugcga gcccgagaac cccugcaagg acaagaccca caacugccac     1980

aagcacgccg agugcaucua ccugggccac uucagcgacc ccauguacaa gugcgagugc     2040

cagaccggcu acgccggcga cggccugauc ugcggcgagg acagcgaccu ggacggcugg     2100

cccaaccuga accuggugug cgccaccaac gccaccuacc acugcaucaa ggacaacugc     2160

ccccaccugc ccaacagcgg ccaggaggac uucgacaagg acggcaucgg cgacgccugc     2220

gacgacgacg acgacaacga cggcgugacc gacgagaagg acaacugcca gcugcuguuc     2280

aaccccagac aggccgacua cgacaaggac gaggugggcg acagaugcga caacugcccc     2340

uacgugcaca accccgccca gaucgacacc gacaacaacg gcgagggcga cgccugcagc     2400

guggacaucg acggcgacga cguguucaac gagagagaca acugccccua cguguacaac     2460

accgaccaga gagacaccga cggcgacggc gugggcgacc acugcgacaa cugcccccug     2520

gugcacaacc ccgaccagac cgacguggac aacgaccugg ugggcgacca gugcgacaac     2580

aacgaggaca ucgacgacga cggccaccag aacaaccagg acaacugccc cuacaucagc     2640

aacgccaacc aggccgacca cgacagagac ggccagggcg acgccugcga ccccgacgac     2700

gacaacgacg gcgugcccga cgacagagac aacugcagac ugguguucaa ccccgaccag     2760

gaggaccugg acggcgacgg cagaggcgac aucugcaagg acgacuucga caacgacaac     2820

auccccgaca ucgacgacgu gugccccgag aacaacgcca ucagcgagac cgacuucaga     2880

aacuuccaga uggugccccu ggaccccaag ggcaccaccc agaucgaccc caacugggug     2940

aucagacacc agggcaagga gcuggugcag accgccaaca gcgaccccgg caucgccgug     3000

ggcuucgacg aguucggcag cguggacuuc agcggcaccu ucuacgugaa caccgacaga     3060

gacgacgacu acgccggcuu cguguucggc uaccagagca gcagcagauu cuacguggug     3120

auguggaagc aggugaccca gaccuacugg gaggaccagc ccaccagagc cuacggcuac     3180

agcggcguga gccugaaggu ggugaacagc accaccggca ccggcgagca ccugagaaac     3240

gcccuguggc acaccggcaa cacccccggc caggugagaa cccuguggca cgaccccaga     3300

aacaucggcu ggaaggacua caccgccuac agauggcacc ugacccacag acccaagacc     3360

ggcuacauca gagugcuggu gcacgagggc aagcagguga uggccgacag cggccccauc     3420

uacgaccaga ccuacgccgg cggcagacug ggccuguucg uguucagcca ggagauggug     3480

uacuucagcg accugaagua cgagugcaga gacaucuga                            3519


<210>  7551
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7551
auggugugga gacugguccu ccuggcccuu uggguuuggc ccagcaccca ggcuggccac       60

caagacaagg auacaacguu cgaccuguuu uccaucucua acauuaaucg gaaaaccauc      120

ggggccaagc aguuccgcgg accugauccg ggcgugcccg cguacagauu ugugcgguuc      180

gacuauauuc cucccgucaa cgcugaugac cucagcaaaa ucacaaagau uaugcgccag      240

aaagaggggu uuuuccugac cgcccagcuu aagcaagaug gaaaguccag aggcacacug      300

cucgcccugg aagggccugg acugucucag cggcaguuug agaucgugag caauggcccc      360

gcugacaccc ucgaucugac auacuggauc gacggcaccc gccauguugu gucccuugaa      420

gaugucgggc uggccgacuc ucaguggaaa aacgugacgg uucaaguggc uggagagacc      480

uauagccucc acgucggcug cgaucugauu gacuccuucg cccuugacga accuuuuuac      540

gagcaucugc aggcggagaa gucuagaaug uauguggcca aagggucugc ucgggaaucc      600

cacuuccgcg gacuccugca gaaugugcau cuggucuuug agaacagcgu ugaagauauc      660

cucucuaaga aaggcuguca gcaagggcag ggagccgaga uuaaugcuau cuccgagaac      720

acagaaaccc ugagacuugg cccgcacgug acaaccgagu acgugggccc cagcucugaa      780

cggcgcccug aggucugcga aagauccugu gaggagcugg ggaauauggu gcaggaacuc      840

agcggacugc acguucuugu gaaccaacug uccgagaauc ucaagcgggu cucuaacgac      900

aaucaguucc ugugggaacu gauuggcggg cccccuaaga cgcgcaacau gagcgccugc      960

uggcaggaug gaagauuuuu cgcggagaau gaaacauggg ugguugacuc cuguaccaca     1020

ugcaccugua aaaaguucaa aaccaucugc caucagauua cauguccccc ggccacgugc     1080

gcuagcccuu cuuuugugga gggcgagugu ugccccuccu gccuccacag cgucgauggg     1140

gaagagggau ggucuccuug ggccgaaugg acccaaugua gcgugacaug cggcuccggc     1200

acccagcagc gggggagauc uugugacguc acaagcaaua ccugccuggg acccuccauc     1260

cagacgcgcg cuuguagccu uucuaagugc gauacacgga ucagacaaga cggcgggugg     1320

ucccauugga gccccugguc uuccuguagc gugaccugcg gaguuggcaa cauuacccgc     1380

auccggcugu guaacucccc ugugccgcag augggcggga aaaacugcaa gggaucuggc     1440

agagagacaa aagccuguca gggggccccc ugcccuauug auggacgcug gagccccugg     1500

uccccuuggu cugcuugcac cgucacaugu gcgggcggga uccgggaaag aacgcgcgug     1560

ugcaauagcc ccgagccgca guauggaggc aaggccugug uuggggacgu gcaagagcgg     1620

cagaugugca acaagagauc cuguccuguc gauggcugcc ucagcaaucc cuguuucccu     1680

ggagcucagu gcagcuccuu ucccgacggc agcuggucuu guggguccug cccuguggga     1740

uuccugggca acgggaccca cugugaagac cuugaugagu gcgcccuggu gcccgacauu     1800

ugcuuuagca caucuaaagu uccgcgcugu gucaauaccc agccuggauu ccacugccuc     1860

cccugucccc cucgguacag aggcaaccaa ccgguggggg ugggccugga agccgcuaag     1920

acagagaaac aggucugcga gcccgaaaau ccuuguaagg auaaaaccca uaacugccac     1980

aagcaugccg aguguaucua ccugggacac uuuagcgacc ccauguauaa gugcgaaugu     2040

cagacgggcu acgcggggga uggacucauc ugcggcgagg acuccgaucu ggacgggugg     2100

ccuaaucuua accuggugug ugcuaccaau gccacauauc auugcauuaa agauaacugc     2160

ccccaccucc cuaauagcgg acaagaagac uucgauaagg acggcaucgg ggaugccugu     2220

gacgacgaug acgauaacga cggcguuacc gaugagaaag acaacugcca gcugcuguuu     2280

aauccccggc aggcugauua cgacaaggau gaggugggag accgcuguga uaacugcccg     2340

uauguccaca auccugccca gauugacaca gauaacaaug gcgaagggga cgcuuguucu     2400

guggacaucg auggagacga uguuuucaac gagagagaca auugccccua cguguauaac     2460

accgaucaac gggacacgga uggcgacggg gucggagauc auugugacaa uugcccucuu     2520

gugcacaacc ccgaucagac agacguugac aaugaucucg ugggcgacca gugugauaac     2580

aaugaagaca uugaugacga uggccaucag aacaaucaag acaacugccc guacaucucc     2640

aacgccaauc aggcggauca cgacagagau gggcagggag acgccuguga uccugacgac     2700

gauaacgacg gcguccccga ugaccgcgau aauugccggc ugguguuuaa cccugaccag     2760

gaggaucugg acggggaugg aagaggcgac aucugcaaag augacuucga uaaugacaac     2820

auucccgaca ucgaugacgu gugucccgaa aauaacgcua uuagcgagac cgauuuucgc     2880

aauuuccaaa uggucccucu cgacccgaag gggacaaccc agaucgaucc caacuggguu     2940

auuagacacc agggaaagga gcuggugcaa accgccaauu ccgacccugg caucgcugug     3000

ggcuucgaug aauuuggguc ugucgacuuc agcggaacau uuuacgugaa cacggaucgg     3060

gacgaugacu augccggcuu cguuuuuggg uaccaguccu cuagccgcuu cuaugugguc     3120

auguggaaac aggugaccca gacauacugg gaggaccaac ccaccagagc guauggauac     3180

uccggcguuu cucuuaaggu ggucaauagc acaaccggga cgggagaaca ucugcggaac     3240

gcccucuggc acacaggcaa uaccccuggc caggugcgca cccuguggca ugaucccaga     3300

aacauugggu ggaaagacua uacagcuuac cgguggcacc ugacccaucg cccuaagaca     3360

ggauacauca gaguucuugu gcacgagggc aaacagguca uggccgauuc cgggccgauc     3420

uaugaccaga cguacgcugg aggccggcuc gggcuguuug uguucagcca agaaauggug     3480

uauuuuucug aucugaagua cgagugccgc gacauuuga                            3519


<210>  7552
<211>  3519
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       TSP-2__Homo_sapiens__BAF85118

<400>  7552
augguuugga gauuaguguu acuagcacua uggguauggc caaguaccca agcagggcau       60

caagauaaag auacuacauu ugaucuauuu aguauuucua acauaaauag aaaaacaaua      120

ggugcaaaac aauucagggg uccugauccu ggaguuccag ccuaucguuu uguaagauuu      180

gauuauauac caccuguaaa cgccgaugac uuaucaaaaa uaacaaaaau aaugagacaa      240

aaagaaggcu uuuuucuaac ugcacaacuu aaacaagaug gaaaauccag agguacacua      300

uuagcauuag aagggcccgg auuaucacaa agacaauucg aaauuguaag uaaugggccu      360

gccgauacac uagauuugac guacuggaua gauggaacaa gacacguugu gagcuuagaa      420

gaugucggau uagcagauuc acaauggaaa aauguaacag uacagguugc aggugaaaca      480

uauuccuugc auguaggaug cgauuuaaua gauucguuug ccuuagauga accauucuac      540

gaacaccuac aagcugaaaa aucacggaug uauguagcaa aaggaagugc aagagaguca      600

cauuucagag gacuguuaca aaacguucac uuagucuuug agaauucagu cgaggacaua      660

uuaucaaaga aagguuguca acaaggucaa ggugcagaaa uuaaugcuau aagugagaau      720

acagaaacuc uaagauuagg uccgcaugua acaacggaau augucggucc gagcagcgaa      780

aggagaccag aaguuuguga aagaucaugc gaagaauugg gaaauauggu ccaagaauua      840

ucaggauuac auguacuggu aaaucagcuu ucagaaaauu uaaaacgagu aucaaaugac      900

aaucaauuuu uaugggaauu aauagggggu ccaccuaaaa cuagaaauau gucagcaugc      960

uggcaagaug gaagauucuu cgcugaaaau gaaacauggg uuguagauag uugcacaaca     1020

ugcacaugca aaaaauuuaa aacaaucugu caccaaauua cgugcccacc agcaacaugc     1080

gcaucaccau cauuuguaga aggagaaugc ugucccuccu gcuuacauuc aguugauggu     1140

gaagaaggau ggaguccaug ggcagagugg acacaaugua guguaacaug ugguucggga     1200

acgcaacaaa gaggacgcuc augugaugua acaaguaaca cuugucuugg uccuucaaua     1260

caaacaagag cuugcucauu aucaaaaugu gauacuagga ucagacaaga cggaggaugg     1320

ucacacugga guccaugguc cuccuguucc gugacaugcg gcgucggaaa uauaacaaga     1380

auucgacuau gcaauucccc gguaccacaa augggaggua aaaauuguaa agguagugga     1440

agagagacaa aagcuuguca aggggcaccc uguccaauag auggaaggug gaguccaugg     1500

uccccuuggu cggcauguac uguaacaugu gcggguggaa uucgggaaag aacaagagug     1560

uguaacagcc cugaaccaca guacggagga aaggcaugug uaggagacgu acaggaacgu     1620

caaaugugua auaaaagauc augucccguc gauggauguc uaucuaaucc uuguuuucca     1680

ggcgcacaau guucuuccuu uccugaugga ucauggucau gugguaguug cccagucggg     1740

uuuuuaggga augguacaca uugugaagac cuagacgaau gcgcguuagu uccagauaua     1800

uguuucagua ccucaaaagu gccaagaugu gugaauacac aaccuggauu ucauugcuua     1860

ccauguccac cuagauauag aggcaaccaa ccgguaggcg uugguuuaga agccgcaaaa     1920

acugaaaaac agguuuguga accugaaaau ccuugcaaag acaaaacaca uaauugccac     1980

aaacaugcag aguguauaua ucugggucau uuuucagauc caauguauaa gugugaaugc     2040

caaacagggu acgcaggaga uggacuaaua uguggugagg auucagaucu agauggcugg     2100

ccuaaccuua aucuaguaug ugcaacaaau gcaacauacc auuguauaaa agacaauugc     2160

ccucaucuuc caaacagugg ccaagaagau uucgauaaag auggcauugg agaugcaugu     2220

gacgaugaug acgacaauga uggugucaca gacgaaaaag auaauugcca auuacuuuuu     2280

aaccccagac aagcagauua cgauaaagac gaaguaggag auagauguga uaauugucca     2340

uauguacaua auccggcaca aauagauaca gacaacaacg gagaagguga ugcauguucc     2400

guugauauag auggcgauga uguauucaac gaaagagaua acuguccuua uguuuacaac     2460

acggaucaac gagauacaga uggcgacgga guaggagauc acugcgauaa cuguccuuua     2520

guacauaauc cugaucaaac ugauguagau aacgacuuag uaggagauca gugcgacaac     2580

aaugaagaca uagaugauga uggccaucaa aauaaccagg auaauugucc auauaucuca     2640

aacgcaaacc aagcagauca cgauagagau ggucaggggg augcaugcga cccagacgau     2700

gacaacgacg gaguaccgga ugaccgugau aauugucguc uuguauuuaa uccagaucaa     2760

gaagaucuag acggggacgg aagaggagau auaugcaaag acgauuucga caacgauaau     2820

auaccagaua uugacgacgu uuguccugaa aauaaugcca uuagugaaac ggacuuucgu     2880

aacuuucaaa ugguuccguu agauccaaaa ggaacuacuc aaauagaucc aaacugggua     2940

aucagacauc aaggaaaaga auuaguacaa acagccaauu cagaccccgg aauugcagua     3000

ggguuugaug aauucggauc aguagacuuu ucaggaacau ucuauguaaa uaccgaucgu     3060

gaugacgacu augcaggauu cguauuugga uaucaaaguu cgaguagauu uuacguaguu     3120

auguggaaac aagucaccca gacuuacugg gaagaccaac cuacucgagc uuauggauau     3180

ucugggguca guuuaaaggu aguuaauucc acuacuggaa cgggugaaca uuuaagaaau     3240

gcuuuauggc auacagggaa caccccagga caggucagaa cuuuauggca ugaucccagg     3300

aauauaggau ggaaagacua uacagccuau agauggcauc uaacgcaucg gccaaaaacu     3360

ggauacauaa gaguacuagu ucacgaaggu aagcaaguaa uggcagacag cggaccuaua     3420

uaugaccaaa cuuacgcagg aggaagauua gguuuauucg uuuucuccca ggaaauggua     3480

uacuuuucgg aucuaaaaua ugaaugccgc gacaucuaa                            3519


<210>  7553
<211>  1670
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Tumstatin__Homo_sapiens__Q01955

<400>  7553

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly Ser Thr Gly Asn Pro Gly Glu Pro 
        995                 1000                1005            


Gly Leu Arg Gly Ile Pro Gly Ser Met Gly Asn Met Gly Met Pro Gly 
    1010                1015                1020                


Ser Lys Gly Lys Arg Gly Thr Leu Gly Phe Pro Gly Arg Ala Gly Arg 
1025                1030                1035                1040


Pro Gly Leu Pro Gly Ile His Gly Leu Gln Gly Asp Lys Gly Glu Pro 
                1045                1050                1055    


Gly Tyr Ser Glu Gly Thr Arg Pro Gly Pro Pro Gly Pro Thr Gly Asp 
            1060                1065                1070        


Pro Gly Leu Pro Gly Asp Met Gly Lys Lys Gly Glu Met Gly Gln Pro 
        1075                1080                1085            


Gly Pro Pro Gly His Leu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly 
    1090                1095                1100                


Ser Pro Gly Ser Pro Gly Leu Pro Gly Lys Pro Gly Pro His Gly Asp 
1105                1110                1115                1120


Leu Gly Phe Lys Gly Ile Lys Gly Leu Leu Gly Pro Pro Gly Ile Arg 
                1125                1130                1135    


Gly Pro Pro Gly Leu Pro Gly Phe Pro Gly Ser Pro Gly Pro Met Gly 
            1140                1145                1150        


Ile Arg Gly Asp Gln Gly Arg Asp Gly Ile Pro Gly Pro Ala Gly Glu 
        1155                1160                1165            


Lys Gly Glu Thr Gly Leu Leu Arg Ala Pro Pro Gly Pro Arg Gly Asn 
    1170                1175                1180                


Pro Gly Ala Gln Gly Ala Lys Gly Asp Arg Gly Ala Pro Gly Phe Pro 
1185                1190                1195                1200


Gly Leu Pro Gly Arg Lys Gly Ala Met Gly Asp Ala Gly Pro Arg Gly 
                1205                1210                1215    


Pro Thr Gly Ile Glu Gly Phe Pro Gly Pro Pro Gly Leu Pro Gly Ala 
            1220                1225                1230        


Ile Ile Pro Gly Gln Thr Gly Asn Arg Gly Pro Pro Gly Ser Arg Gly 
        1235                1240                1245            


Ser Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Gly Ser His Val Ile 
    1250                1255                1260                


Gly Ile Lys Gly Asp Lys Gly Ser Met Gly His Pro Gly Pro Lys Gly 
1265                1270                1275                1280


Pro Pro Gly Thr Ala Gly Asp Met Gly Pro Pro Gly Arg Leu Gly Ala 
                1285                1290                1295    


Pro Gly Thr Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Phe Gln 
            1300                1305                1310        


Gly Phe Pro Gly Val Lys Gly Glu Lys Gly Asn Pro Gly Phe Leu Gly 
        1315                1320                1325            


Ser Ile Gly Pro Pro Gly Pro Ile Gly Pro Lys Gly Pro Pro Gly Val 
    1330                1335                1340                


Arg Gly Asp Pro Gly Thr Leu Lys Ile Ile Ser Leu Pro Gly Ser Pro 
1345                1350                1355                1360


Gly Pro Pro Gly Thr Pro Gly Glu Pro Gly Met Gln Gly Glu Pro Gly 
                1365                1370                1375    


Pro Pro Gly Pro Pro Gly Asn Leu Gly Pro Cys Gly Pro Arg Gly Lys 
            1380                1385                1390        


Pro Gly Lys Asp Gly Lys Pro Gly Thr Pro Gly Pro Ala Gly Glu Lys 
        1395                1400                1405            


Gly Asn Lys Gly Ser Lys Gly Glu Pro Gly Pro Ala Gly Ser Asp Gly 
    1410                1415                1420                


Leu Pro Gly Leu Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr 
1425                1430                1435                1440


Trp Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala 
                1445                1450                1455    


Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser 
            1460                1465                1470        


Phe Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly 
        1475                1480                1485            


Thr Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe Leu Phe 
    1490                1495                1500                


Cys Asn Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser 
1505                1510                1515                1520


Tyr Trp Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met Ala Pro Ile 
                1525                1530                1535    


Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu 
            1540                1545                1550        


Gly Pro Ala Ile Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro 
        1555                1560                1565            


Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser Phe Ile 
    1570                1575                1580                


Met Phe Thr Ser Ala Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser 
1585                1590                1595                1600


Pro Gly Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys 
                1605                1610                1615    


His Gly Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp 
            1620                1625                1630        


Leu Ala Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro Ile Pro Ser 
        1635                1640                1645            


Thr Val Lys Ala Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val 
    1650                1655                1660                


Cys Met Lys Lys Arg His 
1665                1670


<210>  7554
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7554
augagcgccc ggaccgcccc caggccgcag gugcuccugc ugccgcuccu gcuggugcuc       60

cuggcggcgg cgcccgcagc cagcaagggu ugugucugua aagacaaagg ccagugcuuc      120

ugugacgggg ccaaagggga gaagggggag aagggcuuuc cuggaccccc cgguucuccu      180

ggccagaaag gauucacagg uccugaaggc uugccuggac cgcagggacc caagggcuuu      240

ccaggacuuc caggacucac ggguuccaaa gguguaaggg gaauaagugg auugccagga      300

uuuucugguu cuccuggacu uccaggcacc ccaggcaaua ccgggccuua cggacuuguc      360

gguguaccag gaugcagugg uucuaagggu gagcaggggu uuccaggacu cccagggaca      420

cugggcuacc cagggauccc gggugcugcu gguuugaaag gacaaaaggg ugcuccugcu      480

aaagaagaag auauagaacu ugaugcaaaa ggcgaccccg gguugccagg ggcuccagga      540

ccccaggguu ugccaggccc uccagguuuu ccugggccug uuggcccacc ugguccuccg      600

ggauucuuug gcuuuccagg agccauggga ccuagaggac cuaaggguca caugggugaa      660

agagugauag gacauaaagg agagcggggu gugaaagggu uaacaggacc cccgggacca      720

ccaggaacag uuauugugac ccuaacuggc ccagauaaca gaacggaccu caagggggaa      780

aagggagaca agggagcaau gggcgagccu ggaccuccug gacccucagg acugccugga      840

gaaucauaug gaucugaaaa gggugcuccu ggagacccug gccugcaggg aaaacccgga      900

aaagauggug uuccuggcuu cccuggaagu gagggaguca agggcaacag ggguuucccu      960

ggguuaaugg gugaagaugg cauuaaggga cagaaagggg acauuggccc uccaggauuu     1020

cgugguccaa cagaauauua ugacacauac caggaaaagg gagaugaagg cacuccaggc     1080

ccaccagggc ccagaggagc ucguggccca caagguccca gugguccccc cggaguuccu     1140

ggaaguccug gaucaucaag gccuggccuc agaggagccc cuggauggcc aggccugaaa     1200

ggaaguaaag gggaacgagg ccgcccagga aaggaugcca uggggacucc ugggucccca     1260

gguugugcug guucaccagg ucuuccagga ucaccgggac cuccaggacc gccaggugac     1320

aucguuuuuc gcaagggucc accuggagau cacggacugc caggcuaucu agggucucca     1380

ggaaucccag gaguugaugg gcccaaagga gaaccaggcc uccuguguac acagugcccu     1440

uauaucccag ggccucccgg ucucccagga uugccagggu uacauggugu aaaaggaauc     1500

ccaggaagac aaggcgcagc uggcuugaaa ggaagcccag gguccccagg aaauacaggu     1560

cuuccaggau uuccagguuu cccaggugcc cagggugacc caggacuuaa aggagaaaaa     1620

ggugaaacac uucagccuga ggggcaagug ggugucccag gugacccggg gcucagaggc     1680

caaccuggga gaaagggcuu ggauggaauu ccuggaacuc cgggagugaa aggauuacca     1740

ggaccuaaag gcgaacuggc ucugaguggu gagaaagggg accaaggucc uccaggggau     1800

ccuggcuccc cugggucccc aggaccugca ggaccagcug gaccaccugg cuacggaccc     1860

caaggagaac cuggucucca gggcacgcaa ggaguuccug gagcccccgg accacccgga     1920

gaagccggcc cuaggggaga gcucaguguu ucaacaccag uuccaggccc accaggaccu     1980

ccagggcccc cuggccaucc uggcccccaa gguccaccug guaucccugg aucccugggg     2040

aaauguggag auccuggucu uccagggccu gauggugaac caggaauucc aggaauugga     2100

uuuccugggc cuccuggacc uaagggagac caagguuuuc cagguacaaa aggaucacug     2160

gguuguccug gaaaaauggg agagccuggg uuaccuggaa agccaggccu cccaggagcc     2220

aagggagaac cagcaguagc caugccugga ggaccaggaa caccagguuu uccaggagaa     2280

agaggcaauu cuggggaaca uggagaaauu ggacucccug gacuuccagg ucucccugga     2340

acuccaggaa augaagggcu ugauggacca cgaggagauc cagggcagcc uggaccaccu     2400

ggagaacaag gacccccagg aaggugcaua gaggguccca ggggagccca aggacuucca     2460

ggcuuaaaug gauugaaagg gcaacaaggc agaagaggua aaacggggcc aaagggagac     2520

ccaggaauuc caggcuugga uagaucagga uuuccuggag aaacuggauc accaggaauu     2580

ccaggucauc aaggugaaau gggaccacug ggucaaagag gauauccagg aaauccggga     2640

auuuuagggc caccagguga agauggagug auugggauga ugggcuuucc uggagccauu     2700

ggcccuccag ggcccccugg gaacccaggc acaccagggc agagggggag cccuggaauu     2760

ccaggaguaa agggccagag aggaacccca ggagccaagg gggaacaagg agauaaagga     2820

aaucccgggc cuucagagau aucccacgua auaggggaca aaggagaacc aggucucaaa     2880

ggauucgcag gaaauccagg ugagaaagga aacagaggcg uuccagggau gccagguuua     2940

aagggccuca aaggacuacc cggaccagca ggaccaccag gccccagagg agauuugggc     3000

agcacuggga auccuggaga accaggacug cgugguauac caggaagcau ggggaacaug     3060

ggcaugccag guucuaaagg aaaaagggga acuuugggau ucccaggucg agcaggaaga     3120

ccaggccucc cagguauuca uggucuccag ggagauaagg gagagccagg uuauucagaa     3180

gguacaaggc caggaccacc gggaccaacg ggggauccag gacugccggg ugauauggga     3240

aagaaaggag aaauggggca accuggccca ccuggacauu uggggccugc uggaccugag     3300

ggagccccug gaaguccugg aaguccuggc cucccaggaa agccaggucc ucauggugau     3360

uuggguuuua aaggaaucaa aggccuccug ggcccuccag gaaucagagg cccuccaggu     3420

cuuccaggau uuccaggauc uccuggacca auggguauaa gaggugacca aggacgugau     3480

ggaauuccug guccagccgg agaaaaggga gaaacggguu uauugagggc cccuccaggc     3540

ccaagaggga acccuggugc ucaaggagcc aaaggagaca ggggagcccc agguuuuccu     3600

ggccucccgg gcagaaaagg ggccauggga gaugcuggac cucgaggacc cacaggcaua     3660

gaaggauucc cagggccacc aggucugccc ggugcaauua ucccuggcca gacaggaaau     3720

cgugguccac caggcucaag aggaagccca ggugcgccug gucccccugg accuccaggg     3780

agucauguaa uaggcauaaa aggagacaaa gggucuaugg gccacccugg cccaaaaggu     3840

ccaccuggaa cugcaggaga caugggacca ccaggucguc ugggagcacc agguacucca     3900

ggucuuccag gacccagagg ugauccugga uuccaggggu uuccaggcgu gaaaggagaa     3960

aaggguaauc cuggauuucu aggauccauu ggaccuccag gaccaauugg gccaaaagga     4020

ccaccuggug uacguggaga cccuggcaca cuuaagauua ucucccuucc aggaagccca     4080

gggccaccug gcacaccugg agaaccaggg augcagggag aaccugggcc accagggcca     4140

ccuggaaacc uaggacccug ugggccaaga gguaagccag gcaaggaugg aaaaccagga     4200

acuccuggac cagcuggaga aaaaggcaac aaagguucua aaggagagcc aggaccagcu     4260

ggaucagaug gauugccagg uuugaaagga aaacguggag acaguggauc accugcaacc     4320

uggacaacga gaggcuuugu cuucacccga cacagucaaa ccacagcaau uccuucaugu     4380

ccagagggga cagugccacu cuacaguggg uuuucuuuuc uuuuuguaca aggaaaucaa     4440

cgagcccacg gacaagaccu uggaacucuu ggcagcugcc ugcagcgauu uaccacaaug     4500

ccauucuuau ucugcaaugu caaugaugua uguaauuuug caucucgaaa ugauuauuca     4560

uacuggcugu caacaccagc ucugaugcca augaacaugg cucccauuac uggcagagcc     4620

cuugagccuu auauaagcag augcacuguu ugugaagguc cugcgaucgc cauagccguu     4680

cacagccaaa ccacugacau uccuccaugu ccucacggcu ggauuucucu cuggaaagga     4740

uuuucauuca ucauguucac aagugcaggu ucugagggca ccgggcaagc acuggccucc     4800

ccuggcuccu gccuggaaga auuccgagcc agcccauuuc uagaauguca uggaagagga     4860

acgugcaacu acuauucaaa uuccuacagu uucuggcugg cuucauuaaa cccagaaaga     4920

auguucagaa agccuauucc aucaacugug aaagcugggg aauuagaaaa aauaauaagu     4980

cgcugucagg ugugcaugaa gaaaagacac uga                                  5013


<210>  7555
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7555
augagcgccc gcaccgcccc ccggccgcag gugcugcucc ugccccugcu ccugguccug       60

cucgcggccg cccccgccgc cuccaagggc ugcgugugca aggacaaggg gcagugcuuc      120

ugcgacggcg cgaaggggga gaagggcgag aagggguucc ccggcccgcc cggcagcccc      180

gggcagaagg gcuucaccgg gcccgagggc cugccggggc cccagggccc caagggcuuc      240

cccgggcugc cgggccucac gggguccaag ggcgugcgcg gcaucagcgg gcugcccggc      300

uucuccggga gccccggccu gcccgggacc ccgggcaaca ccggccccua cgggcucguc      360

ggcgugcccg ggugcuccgg cagcaagggg gagcagggcu uccccggccu gccggggacc      420

cugggcuacc ccgggauccc cggcgccgcc gggcucaagg gccagaaggg cgcccccgcg      480

aaggaggagg acaucgagcu ggacgccaag ggggacccgg gccugcccgg ggcccccggc      540

ccccagggcc ucccggggcc ccccggcuuc ccggggcccg ugggcccccc cgggccgccc      600

ggcuucuucg gcuuccccgg ggccaugggc ccccgggggc cgaagggcca caugggggag      660

cgcgucaucg gccacaaggg cgagcggggg gugaagggcc ugacggggcc ccccggcccc      720

ccggggaccg ugaucgucac ccugaccggc cccgacaacc gcacggaccu caagggcgag      780

aagggggaca agggcgccau gggggagccc ggccccccgg ggcccuccgg ccugcccggc      840

gagagcuacg gguccgagaa gggcgcgccc ggggacccgg gccugcaggg caagcccggg      900

aaggacggcg ugcccggguu ccccggcagc gaggggguga agggcaaccg gggcuucccg      960

gggcucaugg gcgaggacgg gaucaagggc cagaaggggg acaucggccc ccccggcuuc     1020

cgcgggccga ccgaguacua cgacaccuac caggagaagg gcgacgaggg gacccccggc     1080

ccccccgggc cgcggggcgc ccgcggcccc caggggcccu ccggcccccc gggggucccc     1140

ggcagccccg gcuccagccg gcccgggcug cgcggcgccc cgggguggcc cggccugaag     1200

ggguccaagg gcgagcgggg ccgccccggg aaggacgcca ugggcacgcc cgggagcccg     1260

ggcugcgccg ggucccccgg ccuccccggc agccccgggc cgcccggccc ccccggggac     1320

aucguguucc ggaagggccc gcccggggac cacggccugc ccggcuaccu ggggagcccc     1380

ggcaucccgg ggguggacgg ccccaagggg gagcccggcc uccugugcac ccagugcccg     1440

uacauccccg gcccccccgg gcugccgggc cuccccgggc ugcacggcgu caagggcauc     1500

cccgggcgcc agggcgcggc cgggcugaag ggcucccccg ggagcccggg caacaccggc     1560

cuccccgggu uccccggcuu ccccggggcc cagggcgacc cggggcugaa gggcgagaag     1620

ggcgagaccc ugcagcccga ggggcaggug ggcgugcccg gggaccccgg ccuccggggg     1680

cagccgggcc gcaagggccu ggacgggauc cccggcacgc ccggggucaa gggccugccc     1740

gggccgaagg gcgagcucgc ccuguccggc gagaaggggg accagggccc ccccggggac     1800

cccggcagcc cgggcucccc cgggcccgcc ggccccgcgg ggccgcccgg cuacgggccc     1860

cagggcgagc cgggccugca ggggacccag ggcgugcccg gggcccccgg ccccccgggg     1920

gaggccggcc cccggggcga gcucagcgug uccacccccg uccccgggcc gcccggcccc     1980

cccgggccgc ccggccaccc cgggccccag ggcccgcccg gcauccccgg gagccugggc     2040

aagugcgggg accccggccu gccgggcccc gacggggagc ccggcauccc cgggaucggc     2100

uucccggggc cccccggccc gaagggcgac cagggguucc ccggcaccaa ggggucccuc     2160

ggcugccccg ggaagauggg cgagcccggc cugccgggga agcccggccu gcccggggcc     2220

aagggcgagc ccgccguggc gaugccgggg ggccccggca cgcccggguu ccccggcgag     2280

cgcgggaaca gcggcgagca cggggagauc ggccugccgg gccuccccgg gcugcccggc     2340

acccccggga acgagggccu ggacggcccg cggggggacc ccggccagcc cgggcccccg     2400

ggcgagcagg ggccccccgg ccgcugcauc gagggccccc gcggggccca gggccucccg     2460

gggcugaacg gccugaaggg gcagcagggc cggcgcggca agaccgggcc caagggcgac     2520

cccgggaucc ccggccucga ccgguccggg uucccgggcg agaccggcag ccccgggauc     2580

cccggccacc agggggagau gggcccgcug ggccagcgcg gguaccccgg caaccccggg     2640

auccugggcc ccccggggga ggacggcgug aucggcauga ugggguuccc cggcgccauc     2700

gggccccccg gcccgcccgg gaaccccggc acgcccggcc agcggggguc cccgggcauc     2760

cccgggguca agggccagcg cgggaccccc ggcgccaagg gcgagcaggg ggacaagggc     2820

aaccccgggc cgagcgagau cucccacgug aucggcgaca agggggagcc cggccucaag     2880

ggcuucgcgg ggaaccccgg cgagaagggg aaccggggcg uccccggcau gccggggcug     2940

aagggccuga aggggcuccc cggccccgcc gggcccccgg gcccccgcgg cgaccugggg     3000

agcaccggca accccgggga gcccggccug cgggggaucc cgggcuccau gggcaacaug     3060

gggaugcccg gcagcaaggg gaagcgcggc acccucgggu uccccggccg ggccggccgc     3120

ccggggcugc ccggcaucca cgggcugcag ggcgacaagg gcgagcccgg guacuccgag     3180

ggcacgcggc ccgggccgcc cggccccacc ggggaccccg gccucccggg cgacaugggg     3240

aagaagggcg agauggggca gcccggcccc cccgggcacc ugggcccggc cggccccgag     3300

ggggcccccg gcagccccgg gagcccgggc cugcccggga agcccggccc ccacggcgac     3360

cucggguuca agggcaucaa ggggcugcug ggcccgcccg ggauccgcgg cccccccggc     3420

cucccggggu uccccggcuc ccccgggccc augggcaucc ggggcgacca ggggcgcgac     3480

ggcaucccgg ggcccgcggg cgagaagggg gagaccggcc ugcugcgggc ccccccgggc     3540

ccccgcggga accccggcgc ccagggggcc aagggcgacc ggggggcccc cggcuucccg     3600

ggccuccccg ggcgcaaggg cgcgaugggg gacgccggcc cccgcgggcc caccggcauc     3660

gagggcuucc cggggccccc cggccugccc ggggccauca ucccgggcca gacggggaac     3720

cggggccccc ccggcagccg cggguccccc ggcgccccgg ggccccccgg ccccccgggc     3780

agccacguga ucgggaucaa gggcgacaag ggguccaugg gccaccccgg gcccaagggc     3840

cccccgggca ccgccgggga caugggcccc cccgggcggc ugggcgcgcc ggggaccccc     3900

ggccuccccg gcccccgcgg ggacccgggc uuccaggggu uccccggcgu gaagggggag     3960

aagggcaacc ccggcuuccu ggggagcauc ggccccccgg ggcccaucgg ccccaagggc     4020

cccccggggg uccggggcga ccccgggacc cugaagauca ucucccuccc cggcagcccc     4080

gggccgcccg gcacgcccgg cgagcccggg augcagggcg agccggggcc ccccggcccc     4140

ccggggaacc ugggccccug cggcccccgc gggaagcccg gcaaggacgg gaagccgggc     4200

acccccgggc ccgccggcga gaagggcaac aaggggucca agggcgagcc ggggcccgcc     4260

ggcagcgacg ggcugcccgg ccucaagggc aagcgggggg acuccggcag ccccgccacc     4320

uggaccaccc gcggguucgu guucacgcgg cacucccaga ccaccgcgau cccgagcugc     4380

cccgagggca ccgugccccu guacuccggc uucagcuucc uguucgucca ggggaaccag     4440

cgcgcccacg gccaggaccu cgggacgcug ggcuccugcc ugcagcgguu caccaccaug     4500

cccuuccucu ucugcaacgu gaacgacgug ugcaacuucg ccagccgcaa cgacuacagc     4560

uacuggcugu ccaccccggc ccugaugccc augaacaugg cccccaucac ggggcgggcg     4620

cucgagcccu acaucagccg cugcaccguc ugcgagggcc cggccaucgc caucgccgug     4680

cacucccaga ccaccgacau cccccccugc ccccacggcu ggaucagccu guggaagggg     4740

uucuccuuca ucauguucac gagcgccggc uccgagggga ccggccaggc gcuggccagc     4800

ccgggguccu gccucgagga guuccgggcc agccccuucc uggagugcca cggccgcggc     4860

accugcaacu acuacuccaa cagcuacucc uucuggcugg ccagccucaa ccccgagcgg     4920

auguuccgca agcccauccc guccaccgug aaggccgggg agcuggagaa gaucaucagc     4980

cggugccagg ucugcaugaa gaagcgccac uga                                  5013


<210>  7556
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7556
auguccgccc gcaccgcccc ccgcccccag guccuccucc ucccccuccu ccucguccuc       60

cucgccgccg cccccgccgc cuccaagggc ugcgucugca aggacaaggg ccagugcuuc      120

ugcgacggcg ccaagggcga gaagggcgag aagggcuucc ccggcccccc cggcuccccc      180

ggccagaagg gcuucaccgg ccccgagggc cuccccggcc cccagggccc caagggcuuc      240

cccggccucc ccggccucac cggcuccaag ggcguccgcg gcaucuccgg ccuccccggc      300

uucuccggcu cccccggccu ccccggcacc cccggcaaca ccggccccua cggccucguc      360

ggcguccccg gcugcuccgg cuccaagggc gagcagggcu uccccggccu ccccggcacc      420

cucggcuacc ccggcauccc cggcgccgcc ggccucaagg gccagaaggg cgcccccgcc      480

aaggaggagg acaucgagcu cgacgccaag ggcgaccccg gccuccccgg cgcccccggc      540

ccccagggcc uccccggccc ccccggcuuc cccggccccg ucggcccccc cggccccccc      600

ggcuucuucg gcuuccccgg cgccaugggc ccccgcggcc ccaagggcca caugggcgag      660

cgcgucaucg gccacaaggg cgagcgcggc gucaagggcc ucaccggccc ccccggcccc      720

cccggcaccg ucaucgucac ccucaccggc cccgacaacc gcaccgaccu caagggcgag      780

aagggcgaca agggcgccau gggcgagccc ggcccccccg gccccuccgg ccuccccggc      840

gaguccuacg gcuccgagaa gggcgccccc ggcgaccccg gccuccaggg caagcccggc      900

aaggacggcg uccccggcuu ccccggcucc gagggcguca agggcaaccg cggcuucccc      960

ggccucaugg gcgaggacgg caucaagggc cagaagggcg acaucggccc ccccggcuuc     1020

cgcggcccca ccgaguacua cgacaccuac caggagaagg gcgacgaggg cacccccggc     1080

ccccccggcc cccgcggcgc ccgcggcccc cagggccccu ccggcccccc cggcgucccc     1140

ggcucccccg gcuccucccg ccccggccuc cgcggcgccc ccggcuggcc cggccucaag     1200

ggcuccaagg gcgagcgcgg ccgccccggc aaggacgcca ugggcacccc cggcuccccc     1260

ggcugcgccg gcucccccgg ccuccccggc ucccccggcc cccccggccc ccccggcgac     1320

aucgucuucc gcaagggccc ccccggcgac cacggccucc ccggcuaccu cggcuccccc     1380

ggcauccccg gcgucgacgg ccccaagggc gagcccggcc uccucugcac ccagugcccc     1440

uacauccccg gcccccccgg ccuccccggc cuccccggcc uccacggcgu caagggcauc     1500

cccggccgcc agggcgccgc cggccucaag ggcucccccg gcucccccgg caacaccggc     1560

cuccccggcu uccccggcuu ccccggcgcc cagggcgacc ccggccucaa gggcgagaag     1620

ggcgagaccc uccagcccga gggccagguc ggcguccccg gcgaccccgg ccuccgcggc     1680

cagcccggcc gcaagggccu cgacggcauc cccggcaccc ccggcgucaa gggccucccc     1740

ggccccaagg gcgagcucgc ccucuccggc gagaagggcg accagggccc ccccggcgac     1800

cccggcuccc ccggcucccc cggccccgcc ggccccgccg gcccccccgg cuacggcccc     1860

cagggcgagc ccggccucca gggcacccag ggcguccccg gcgcccccgg cccccccggc     1920

gaggccggcc cccgcggcga gcucuccguc uccacccccg uccccggccc ccccggcccc     1980

cccggccccc ccggccaccc cggcccccag ggcccccccg gcauccccgg cucccucggc     2040

aagugcggcg accccggccu ccccggcccc gacggcgagc ccggcauccc cggcaucggc     2100

uuccccggcc cccccggccc caagggcgac cagggcuucc ccggcaccaa gggcucccuc     2160

ggcugccccg gcaagauggg cgagcccggc cuccccggca agcccggccu ccccggcgcc     2220

aagggcgagc ccgccgucgc caugcccggc ggccccggca cccccggcuu ccccggcgag     2280

cgcggcaacu ccggcgagca cggcgagauc ggccuccccg gccuccccgg ccuccccggc     2340

acccccggca acgagggccu cgacggcccc cgcggcgacc ccggccagcc cggccccccc     2400

ggcgagcagg gcccccccgg ccgcugcauc gagggccccc gcggcgccca gggccucccc     2460

ggccucaacg gccucaaggg ccagcagggc cgccgcggca agaccggccc caagggcgac     2520

cccggcaucc ccggccucga ccgcuccggc uuccccggcg agaccggcuc ccccggcauc     2580

cccggccacc agggcgagau gggcccccuc ggccagcgcg gcuaccccgg caaccccggc     2640

auccucggcc cccccggcga ggacggcguc aucggcauga ugggcuuccc cggcgccauc     2700

ggcccccccg gcccccccgg caaccccggc acccccggcc agcgcggcuc ccccggcauc     2760

cccggcguca agggccagcg cggcaccccc ggcgccaagg gcgagcaggg cgacaagggc     2820

aaccccggcc ccuccgagau cucccacguc aucggcgaca agggcgagcc cggccucaag     2880

ggcuucgccg gcaaccccgg cgagaagggc aaccgcggcg uccccggcau gcccggccuc     2940

aagggccuca agggccuccc cggccccgcc ggcccccccg gcccccgcgg cgaccucggc     3000

uccaccggca accccggcga gcccggccuc cgcggcaucc ccggcuccau gggcaacaug     3060

ggcaugcccg gcuccaaggg caagcgcggc acccucggcu uccccggccg cgccggccgc     3120

cccggccucc ccggcaucca cggccuccag ggcgacaagg gcgagcccgg cuacuccgag     3180

ggcacccgcc ccggcccccc cggccccacc ggcgaccccg gccuccccgg cgacaugggc     3240

aagaagggcg agaugggcca gcccggcccc cccggccacc ucggccccgc cggccccgag     3300

ggcgcccccg gcucccccgg cucccccggc cuccccggca agcccggccc ccacggcgac     3360

cucggcuuca agggcaucaa gggccuccuc ggcccccccg gcauccgcgg cccccccggc     3420

cuccccggcu uccccggcuc ccccggcccc augggcaucc gcggcgacca gggccgcgac     3480

ggcauccccg gccccgccgg cgagaagggc gagaccggcc uccuccgcgc cccccccggc     3540

ccccgcggca accccggcgc ccagggcgcc aagggcgacc gcggcgcccc cggcuucccc     3600

ggccuccccg gccgcaaggg cgccaugggc gacgccggcc cccgcggccc caccggcauc     3660

gagggcuucc ccggcccccc cggccucccc ggcgccauca uccccggcca gaccggcaac     3720

cgcggccccc ccggcucccg cggcuccccc ggcgcccccg gcccccccgg cccccccggc     3780

ucccacguca ucggcaucaa gggcgacaag ggcuccaugg gccaccccgg ccccaagggc     3840

ccccccggca ccgccggcga caugggcccc cccggccgcc ucggcgcccc cggcaccccc     3900

ggccuccccg gcccccgcgg cgaccccggc uuccagggcu uccccggcgu caagggcgag     3960

aagggcaacc ccggcuuccu cggcuccauc ggcccccccg gccccaucgg ccccaagggc     4020

ccccccggcg uccgcggcga ccccggcacc cucaagauca ucucccuccc cggcuccccc     4080

ggcccccccg gcacccccgg cgagcccggc augcagggcg agcccggccc ccccggcccc     4140

cccggcaacc ucggccccug cggcccccgc ggcaagcccg gcaaggacgg caagcccggc     4200

acccccggcc ccgccggcga gaagggcaac aagggcucca agggcgagcc cggccccgcc     4260

ggcuccgacg gccuccccgg ccucaagggc aagcgcggcg acuccggcuc ccccgccacc     4320

uggaccaccc gcggcuucgu cuucacccgc cacucccaga ccaccgccau ccccuccugc     4380

cccgagggca ccgucccccu cuacuccggc uucuccuucc ucuucgucca gggcaaccag     4440

cgcgcccacg gccaggaccu cggcacccuc ggcuccugcc uccagcgcuu caccaccaug     4500

cccuuccucu ucugcaacgu caacgacguc ugcaacuucg ccucccgcaa cgacuacucc     4560

uacuggcucu ccacccccgc ccucaugccc augaacaugg cccccaucac cggccgcgcc     4620

cucgagcccu acaucucccg cugcaccguc ugcgagggcc ccgccaucgc caucgccguc     4680

cacucccaga ccaccgacau cccccccugc ccccacggcu ggaucucccu cuggaagggc     4740

uucuccuuca ucauguucac cuccgccggc uccgagggca ccggccaggc ccucgccucc     4800

cccggcuccu gccucgagga guuccgcgcc ucccccuucc ucgagugcca cggccgcggc     4860

accugcaacu acuacuccaa cuccuacucc uucuggcucg ccucccucaa ccccgagcgc     4920

auguuccgca agcccauccc cuccaccguc aaggccggcg agcucgagaa gaucaucucc     4980

cgcugccagg ucugcaugaa gaagcgccac uga                                  5013


<210>  7557
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7557
augagcgcca gaaccgcucc caggccucag gugcugcucc uuccacuguu guuaguccug       60

cuagcagccg cgccggcugc cuccaagggc ugcguuugua aagacaaggg gcaaugcuuc      120

ugugauggag caaaagguga gaagggcgaa aaaggguuuc ccggaccucc aggcucuccc      180

ggucagaagg gguucacagg accugagggc cucccaggcc cccaggggcc uaagggauuu      240

ccaggucugc cgggccuuac ugggucaaaa ggagugcggg gcaucagugg ucugcccggg      300

uucagcggau ccccuggcuu gccaggcacg cccgggaaca ccggaccuua cggucucgua      360

ggcgugccag ggugcucugg aucgaagggc gaacaggguu uucccgggcu gccgggcaca      420

cugggauauc cuggcauucc cggggccgcu ggacucaaag gucaaaaggg cgcaccagcc      480

aaagaggaag acauagaguu agaugcuaag ggggacccug gacugcccgg cgccccaggu      540

ccccaggggc uuccuggccc accgggauuc cccggcccug ucgggccacc cggaccucca      600

gguuucuucg gcuuucccgg ggcgauggga ccgcgcggcc cuaaggguca caugggggag      660

cgagugaucg gccauaaagg agaacguggc guuaaggggu ugacuggacc acccggcccu      720

cccgguaccg ugauugucac acugaccggg ccagauaaua gaacugaccu aaaaggagag      780

aagggcgaua aaggugcaau gggcgaaccu gggcccccag gaccgucagg ccucccuggg      840

gagagcuacg gaagugagaa gggcgccccc ggugacccag ggcugcaggg aaaacccggc      900

aaggauggug ugccuggcuu cccagggucc gaaggaguaa agggcaacag gggguuuccc      960

ggacuuaugg gcgaggacgg uaucaaaggg cagaagggag auauuggccc uccggguuuc     1020

cggggcccaa cagaauauua cgacaccuau caagagaaag gggaugaagg aacgcccggc     1080

ccuccagggc cccgcggagc uagaggcccu caggguccgu cugggccccc aggaguuccu     1140

ggcagccccg gcuccucaag gccagggcug cggggagccc cugguuggcc cggcuugaag     1200

gggaguaaag gagagcgcgg ccgaccaggu aaggacgcaa uggggacucc gggaagcccu     1260

ggcugugcug gcucucccgg gcucccagga ucccccgguc cuccaggccc ucccggggac     1320

aucguguuua gaaagggacc gccaggcgau cacggucugc ccggguacuu aggaucaccu     1380

ggcauacccg gcgucgacgg gccaaaagga gagccugguc ugcucugcac ccaguguccc     1440

uauaucccag gcccuccggg gcuucccgga cugccaggcu ugcauggugu gaaggggauu     1500

ccuggaaggc agggcgccgc gggccuaaaa gggagccccg gaaguccagg uaauacaggc     1560

cugccugggu uccccggauu cccgggcgcc caaggugauc cagggcucaa gggagaaaaa     1620

ggcgagacuc ugcagccuga aggccaggug gggguccccg gagacccagg ucuucggggc     1680

caacccgggc guaagggacu ggauggcauc ccugguaccc cggggguuaa gggcuugccc     1740

ggaccaaaag gcgagcucgc acugucuggg gaaaagggag accagggucc ucccggcgau     1800

ccuggguccc caggaagccc cggcccugcu gguccagccg ggcccccggg cuacggaccu     1860

cagggcgagc caggguuaca gggaacacaa ggugugcccg gcgcuccugg gccacccgga     1920

gaggccggcc cgcgcgguga acugucggua ucuaccccug ugcccgggcc accuggaccc     1980

ccaggacccc cuggccaccc agggccgcag ggacccccug gcauuccagg uucccuaggg     2040

aaaugcggag accccggccu cccuggucca gauggcgagc ccgggauccc uggaauaggc     2100

uuuccggggc cacccggacc uaagggcgac caggguuucc ccgggacgaa aggaucacug     2160

ggcuguccag guaagauggg cgaaccuggg cuucccggaa agccaggcuu gccgggggca     2220

aaaggagagc cugccgucgc uaugcccggc gguccaggga cucccggauu uccuggcgaa     2280

agaggcaaca guggggagca uggagagauu ggucugccag gccuccccgg gcugccugga     2340

acaccgggca augaaggucu ugaugggcca aggggagacc ccggccagcc uggcccaccc     2400

ggggagcaag gaccucccgg ucggugcauc gaaggcccac gaggggcgca gggacugccg     2460

ggcuugaacg gucucaaggg gcagcaggga cgcagaggca aaaccggccc uaagggggac     2520

cccggcauuc caggucugga uaggagcggc uucccugggg agacuggauc ccccggcauc     2580

ccaggucacc aaggggagau gggaccuuua ggccagcggg gcuaccccgg gaauccggga     2640

auccuggguc caccuggcga agacggggug auuggaauga ugggcuuucc cggugcaaua     2700

gggccacccg gaccuccggg caacccaggc acacccgggc agcgcggauc uccugguauc     2760

cccggcguua aagggcagag aggaacccca ggcgccaagg gugagcaagg ggauaaagga     2820

aauccuggcc ccagcgaaau uucacacgug aucggcgaca agggggagcc aggacuaaag     2880

gguuucgcug gcaacccugg ggaaaaagga aauaggggcg ucccggguau gcccgggcuc     2940

aagggccuga aaggacuucc aggcccugcc gggcccccag gaccucgugg ugauuugggc     3000

aguacgggga accccggaga gccgggccug cgggguauac caggguccau gggcaauaug     3060

ggaaugccug gcagcaaggg gaaacgagga acccucgguu uucccggcag agcagggagg     3120

ccaggacugc ccggcauuca ugguuuacag ggcgacaagg gggagccugg auauucugaa     3180

ggcacacgcc ccgggccacc uggaccgacu ggcgaucccg gucugccagg ggacauggga     3240

aagaaaggcg agauggguca gccugggccc ccaggccacc uuggaccugc cggccccgaa     3300

ggggcuccgg gaucaccugg caguccaggu uugcccggga agccuggacc acauggcgau     3360

cucgguuuca aaggcaucaa ggggcugcua ggacccccug gcauccgggg gccacccgga     3420

cugccgggcu uuccugguag ccccgggcca augggaauua gaggcgacca aggcagggau     3480

gggauccccg gaccugccgg ugagaaaggc gaaaccgggc uccugcgcgc accacccgga     3540

ccucgaggca acccaggugc gcagggggcu aagggagacc ggggcgcccc gggcuucccc     3600

gggcuuccug gacguaaggg ugcaaugggc gaugccgggc caagaggacc cacaggcauu     3660

gaggguuuuc cugggccacc cggauugccg ggcgcuauaa ucccuggcca gacugggaau     3720

aggggaccac ccgguucccg cggcucuccu ggggcccccg gaccaccggg cccucccggu     3780

ucgcacguga uugggaucaa aggagacaag ggcagcaugg gccacccagg gcccaaagga     3840

ccuccaggua ccgcaggcga cauggggccc ccuggacggc ugggcgcucc agguacaccg     3900

ggguuacccg gaccuagagg cgauccaggc uuccaggggu uucccggagu aaagggugag     3960

aaaggcaacc cuggguuccu cggauccauc ggcccacccg guccuauugg gccgaaggga     4020

cccccaggcg uuaggggcga cccugggacc cugaagauaa ucucacuucc cggaagucca     4080

gguccucccg gcacuccagg ggaaccggga augcaaggcg agccuggucc cccagggccc     4140

ccuggcaacc ugggaccaug uggcccccga gggaaaccug gaaaggaugg uaaaccgggc     4200

acgcccgggc cagccggaga aaagggcaau aaagguucua agggggagcc uggccccgcg     4260

ggaagcgacg gcuugccagg gcucaaagga aagcgcggug auuccggcag cccugccaca     4320

uggaccacuc ggggguucgu guuuaccaga cauucacaga caaccgcuau ucccucuugc     4380

ccagaaggaa cugucccgcu guacuccggc uucaguuuuc uauucgugca ggguaaccag     4440

agggcacacg gccaagaccu ggggacacuc ggaagcugcc ugcagcguuu uacgaccaug     4500

ccuuucuugu uuuguaaugu caacgaugug ugcaauuucg ccucucgcaa cgacuauucc     4560

uacuggcuuu caacucccgc ucugaugcca augaauaugg ccccuaucac aggccgggca     4620

uuagagcccu auauuaguag auguaccguu ugcgaggggc cagcgaucgc cauagcugug     4680

cauagccaga caacugauau cccucccugu ccgcacggau ggauuucgcu cuggaagggc     4740

uuuuccuuca ucauguuuac cucugccggu agcgaaggga cgggacaggc acuggcuuca     4800

ccaggcaguu gccuugagga auuuagggcc ucccccuuuc uggaguguca uggucgaggg     4860

accugcaacu acuauucuaa uagcuacucc uucuggcuag caucacucaa cccugagcgg     4920

auguuccgca aaccaauucc cagcacagua aaggccggcg aacuggagaa aaucauaagu     4980

agaugucaag ucugcaugaa gaaaaggcac uga                                  5013


<210>  7558
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7558
augagcgcca gaaccgcccc cagaccccag gugcugcugc ugccccugcu gcuggugcug       60

cuggccgccg cccccgccgc cagcaagggc ugcgugugca aggacaaggg ccagugcuuc      120

ugcgacggcg ccaagggcga gaagggcgag aagggcuucc ccggcccccc cggcagcccc      180

ggccagaagg gcuucaccgg ccccgagggc cugcccggcc cccagggccc caagggcuuc      240

cccggccugc ccggccugac cggcagcaag ggcgugagag gcaucagcgg ccugcccggc      300

uucagcggca gccccggccu gcccggcacc cccggcaaca ccggccccua cggccuggug      360

ggcgugcccg gcugcagcgg cagcaagggc gagcagggcu uccccggccu gcccggcacc      420

cugggcuacc ccggcauccc cggcgccgcc ggccugaagg gccagaaggg cgcccccgcc      480

aaggaggagg acaucgagcu ggacgccaag ggcgaccccg gccugcccgg cgcccccggc      540

ccccagggcc ugcccggccc ccccggcuuc cccggccccg ugggcccccc cggccccccc      600

ggcuucuucg gcuuccccgg cgccaugggc cccagaggcc ccaagggcca caugggcgag      660

agagugaucg gccacaaggg cgagagaggc gugaagggcc ugaccggccc ccccggcccc      720

cccggcaccg ugaucgugac ccugaccggc cccgacaaca gaaccgaccu gaagggcgag      780

aagggcgaca agggcgccau gggcgagccc ggcccccccg gccccagcgg ccugcccggc      840

gagagcuacg gcagcgagaa gggcgccccc ggcgaccccg gccugcaggg caagcccggc      900

aaggacggcg ugcccggcuu ccccggcagc gagggcguga agggcaacag aggcuucccc      960

ggccugaugg gcgaggacgg caucaagggc cagaagggcg acaucggccc ccccggcuuc     1020

agaggcccca ccgaguacua cgacaccuac caggagaagg gcgacgaggg cacccccggc     1080

ccccccggcc ccagaggcgc cagaggcccc cagggcccca gcggcccccc cggcgugccc     1140

ggcagccccg gcagcagcag acccggccug agaggcgccc ccggcuggcc cggccugaag     1200

ggcagcaagg gcgagagagg cagacccggc aaggacgcca ugggcacccc cggcagcccc     1260

ggcugcgccg gcagccccgg ccugcccggc agccccggcc cccccggccc ccccggcgac     1320

aucguguuca gaaagggccc ccccggcgac cacggccugc ccggcuaccu gggcagcccc     1380

ggcauccccg gcguggacgg ccccaagggc gagcccggcc ugcugugcac ccagugcccc     1440

uacauccccg gcccccccgg ccugcccggc cugcccggcc ugcacggcgu gaagggcauc     1500

cccggcagac agggcgccgc cggccugaag ggcagccccg gcagccccgg caacaccggc     1560

cugcccggcu uccccggcuu ccccggcgcc cagggcgacc ccggccugaa gggcgagaag     1620

ggcgagaccc ugcagcccga gggccaggug ggcgugcccg gcgaccccgg ccugagaggc     1680

cagcccggca gaaagggccu ggacggcauc cccggcaccc ccggcgugaa gggccugccc     1740

ggccccaagg gcgagcuggc ccugagcggc gagaagggcg accagggccc ccccggcgac     1800

cccggcagcc ccggcagccc cggccccgcc ggccccgccg gcccccccgg cuacggcccc     1860

cagggcgagc ccggccugca gggcacccag ggcgugcccg gcgcccccgg cccccccggc     1920

gaggccggcc ccagaggcga gcugagcgug agcacccccg ugcccggccc ccccggcccc     1980

cccggccccc ccggccaccc cggcccccag ggcccccccg gcauccccgg cagccugggc     2040

aagugcggcg accccggccu gcccggcccc gacggcgagc ccggcauccc cggcaucggc     2100

uuccccggcc cccccggccc caagggcgac cagggcuucc ccggcaccaa gggcagccug     2160

ggcugccccg gcaagauggg cgagcccggc cugcccggca agcccggccu gcccggcgcc     2220

aagggcgagc ccgccguggc caugcccggc ggccccggca cccccggcuu ccccggcgag     2280

agaggcaaca gcggcgagca cggcgagauc ggccugcccg gccugcccgg ccugcccggc     2340

acccccggca acgagggccu ggacggcccc agaggcgacc ccggccagcc cggccccccc     2400

ggcgagcagg gcccccccgg cagaugcauc gagggcccca gaggcgccca gggccugccc     2460

ggccugaacg gccugaaggg ccagcagggc agaagaggca agaccggccc caagggcgac     2520

cccggcaucc ccggccugga cagaagcggc uuccccggcg agaccggcag ccccggcauc     2580

cccggccacc agggcgagau gggcccccug ggccagagag gcuaccccgg caaccccggc     2640

auccugggcc cccccggcga ggacggcgug aucggcauga ugggcuuccc cggcgccauc     2700

ggcccccccg gcccccccgg caaccccggc acccccggcc agagaggcag ccccggcauc     2760

cccggcguga agggccagag aggcaccccc ggcgccaagg gcgagcaggg cgacaagggc     2820

aaccccggcc ccagcgagau cagccacgug aucggcgaca agggcgagcc cggccugaag     2880

ggcuucgccg gcaaccccgg cgagaagggc aacagaggcg ugcccggcau gcccggccug     2940

aagggccuga agggccugcc cggccccgcc ggcccccccg gccccagagg cgaccugggc     3000

agcaccggca accccggcga gcccggccug agaggcaucc ccggcagcau gggcaacaug     3060

ggcaugcccg gcagcaaggg caagagaggc acccugggcu uccccggcag agccggcaga     3120

cccggccugc ccggcaucca cggccugcag ggcgacaagg gcgagcccgg cuacagcgag     3180

ggcaccagac ccggcccccc cggccccacc ggcgaccccg gccugcccgg cgacaugggc     3240

aagaagggcg agaugggcca gcccggcccc cccggccacc ugggccccgc cggccccgag     3300

ggcgcccccg gcagccccgg cagccccggc cugcccggca agcccggccc ccacggcgac     3360

cugggcuuca agggcaucaa gggccugcug ggcccccccg gcaucagagg cccccccggc     3420

cugcccggcu uccccggcag ccccggcccc augggcauca gaggcgacca gggcagagac     3480

ggcauccccg gccccgccgg cgagaagggc gagaccggcc ugcugagagc cccccccggc     3540

cccagaggca accccggcgc ccagggcgcc aagggcgaca gaggcgcccc cggcuucccc     3600

ggccugcccg gcagaaaggg cgccaugggc gacgccggcc ccagaggccc caccggcauc     3660

gagggcuucc ccggcccccc cggccugccc ggcgccauca uccccggcca gaccggcaac     3720

agaggccccc ccggcagcag aggcagcccc ggcgcccccg gcccccccgg cccccccggc     3780

agccacguga ucggcaucaa gggcgacaag ggcagcaugg gccaccccgg ccccaagggc     3840

ccccccggca ccgccggcga caugggcccc cccggcagac ugggcgcccc cggcaccccc     3900

ggccugcccg gccccagagg cgaccccggc uuccagggcu uccccggcgu gaagggcgag     3960

aagggcaacc ccggcuuccu gggcagcauc ggcccccccg gccccaucgg ccccaagggc     4020

ccccccggcg ugagaggcga ccccggcacc cugaagauca ucagccugcc cggcagcccc     4080

ggcccccccg gcacccccgg cgagcccggc augcagggcg agcccggccc ccccggcccc     4140

cccggcaacc ugggccccug cggccccaga ggcaagcccg gcaaggacgg caagcccggc     4200

acccccggcc ccgccggcga gaagggcaac aagggcagca agggcgagcc cggccccgcc     4260

ggcagcgacg gccugcccgg ccugaagggc aagagaggcg acagcggcag ccccgccacc     4320

uggaccacca gaggcuucgu guucaccaga cacagccaga ccaccgccau ccccagcugc     4380

cccgagggca ccgugccccu guacagcggc uucagcuucc uguucgugca gggcaaccag     4440

agagcccacg gccaggaccu gggcacccug ggcagcugcc ugcagagauu caccaccaug     4500

cccuuccugu ucugcaacgu gaacgacgug ugcaacuucg ccagcagaaa cgacuacagc     4560

uacuggcuga gcacccccgc ccugaugccc augaacaugg cccccaucac cggcagagcc     4620

cuggagcccu acaucagcag augcaccgug ugcgagggcc ccgccaucgc caucgccgug     4680

cacagccaga ccaccgacau cccccccugc ccccacggcu ggaucagccu guggaagggc     4740

uucagcuuca ucauguucac cagcgccggc agcgagggca ccggccaggc ccuggccagc     4800

cccggcagcu gccuggagga guucagagcc agccccuucc uggagugcca cggcagaggc     4860

accugcaacu acuacagcaa cagcuacagc uucuggcugg ccagccugaa ccccgagaga     4920

auguucagaa agcccauccc cagcaccgug aaggccggcg agcuggagaa gaucaucagc     4980

agaugccagg ugugcaugaa gaagagacac uga                                  5013


<210>  7559
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7559
augagcgcca gaaccgcucc ccggccucag gugcugcucc ugccgcuucu gcucguccug       60

cuugccgcgg cucccgccgc cuccaagggc ugcguuugua aagacaaggg gcaaugcuuc      120

ugugauggag cuaaaggcga gaagggggaa aaaggauuuc cuggaccccc ugggucuccc      180

ggacagaagg gcuucacagg cccugagggg cugccgggac cccagggccc uaagggguuu      240

cccggacucc cuggccugac ggggagcaaa ggagugcgcg gcaucuccgg ccugcccggg      300

uucucuggaa gcccgggccu cccugggacc cccggaaaca caggcccuua cgggcuggug      360

ggaguccccg gcugcuccgg cucuaagggg gaacagggau uucccggccu uccugggacc      420

cugggauauc cgggcauucc cggggccgcu ggccucaaag gacaaaaggg cgccccugcg      480

aaagaggaag acaucgagcu ggaugccaag ggggaccccg gacuuccugg cgcucccggg      540

ccgcagggac ugccugggcc cccuggcuuc cccggcccug ugggaccccc gggcccuccc      600

ggguuuuucg gauuucccgg cgccaugggg ccuagaggac cgaagggcca caugggggag      660

cggguuauug gccauaaagg agaacgcggc gugaaggggc ucacaggacc cccugggccc      720

ccuggcaccg ucaucgugac acugaccgga cccgauaaua gaacggaccu gaaaggcgag      780

aagggggaua aaggcgcuau gggagaaccu gggcccccgg gcccuagcgg acuccccggc      840

gaguccuacg ggagcgagaa gggagccccu ggcgaccccg gccugcaggg gaaaccggga      900

aaggauggcg uuccuggguu ccccggaucu gaaggcguga aggggaaccg gggauuuccu      960

ggccuuaugg gcgaggacgg gauuaaagga cagaagggcg auaucgggcc gcccggauuc     1020

cgcggcccua ccgaauauua cgacacauau caagagaaag gggaugaagg aaccccgggg     1080

cccccuggcc ccagaggcgc gcggggaccu cagggccccu ccgggccucc gggagucccc     1140

ggcagcccug ggucuucccg ccccggacug agaggcgccc cuggcuggcc cgggcucaag     1200

ggaagcaaag gcgagcgggg gcgcccggga aaggacgcua ugggcacacc ugggucuccc     1260

ggaugugccg gcucccccgg ccugccuggg agccccggac cuccggggcc cccuggcgac     1320

aucguguuua gaaagggacc cccuggcgau cacgggcuuc ccggauaccu gggcuccccg     1380

ggcauuccug ggguggacgg acccaaaggc gagccugggc uccugugcac ccaguguccc     1440

uauaucccug gacccccggg ccugccuggg cuccccggac ugcauggcgu caagggcauu     1500

cccgggcggc agggagcugc cggccuuaaa gggucuccug gaagcccggg caauacgggg     1560

cugcccggcu ucccuggauu ccccggcgcc caaggggauc cuggacucaa gggcgaaaaa     1620

ggggagacac ugcagcccga aggacagguu ggcgugccug gggacccggg ccuucgcgga     1680

caacccggca gaaaggggcu ggauggaauc ccuggcaccc ccggggugaa gggacucccu     1740

ggccccaaag gggagcuggc ucuguccggc gaaaagggag accagggccc gccuggggau     1800

cccggaagcc ccggcucucc ugggcccgcg ggaccugccg gcccgcccgg cuacgggccu     1860

cagggagagc ccggccucca ggggacacaa ggagucccug gcgcucccgg gccgccugga     1920

gaggccggcc cccggggcga acuguccgug agcaccccug uucccgggcc ucccggaccg     1980

ccuggcccuc ccgggcaccc cggaccgcag gggcccccug gcauucccgg aucucuuggc     2040

aaaugcggcg acccugggcu gcccggaccu gauggcgagc ccgggauccc gggaauuggc     2100

uuuccugggc ccccuggacc caagggcgac cagggcuucc cggggaccaa aggaagccuc     2160

ggcuguccug ggaagauggg agaacccggc cugcccggga agccuggacu gcccggcgcc     2220

aaaggcgagc cugcuguggc caugcccggg ggacccggca caccuggguu ucccggagaa     2280

agaggcaacu ccggggagca uggagagauc ggccuuccug gccuccccgg gcugccugga     2340

acgccgggca augaagggcu ggauggaccc cgcggcgacc cugggcagcc cggaccuccc     2400

ggcgagcaag gcccgccugg gcggugcauc gaaggaccca gaggcgcgca ggggcucccc     2460

ggacugaacg gccuuaaggg gcagcagggc cgccggggaa aaaccggccc uaagggggac     2520

cccggcauuc cuggccugga uagaucuggg uucccgggag agacaggcag ccccgggauc     2580

ccuggccacc aaggagagau gggcccccuc gggcagcgcg gauacccugg caaucccggg     2640

auucugggac cgccuggcga agacgggguc aucggcauga ugggauuucc cggcgcuauu     2700

gggccucccg gaccgccugg caaccccggg acccccggac agcggggcuc cccugggauc     2760

cccggcguga aaggacagag aggcacaccu ggggccaagg gagagcaagg cgauaaaggg     2820

aauccgggac ccagcgaaau cucucacguu auuggcgaca agggcgagcc ugggcugaag     2880

ggauucgccg gcaaccccgg ggaaaaagga aaucgcggcg ugccugggau gcccggacuu     2940

aagggccuca aaggccugcc ugggccggcu ggacccccug gccccagagg ggaucuggga     3000

uccaccggca acccugggga gcccggacuc cggggcaucc cgggcagcau ggggaauaug     3060

ggaaugccug gcucuaaggg gaaacgcgga acgcugggcu uucccgggcg ggccggaaga     3120

cccggccuuc cuggcauuca ugggcugcag ggagacaagg gcgagcccgg guauuccgaa     3180

ggaacacggc cuggcccgcc cgggccuacc ggagaucccg gccucccugg cgacaugggg     3240

aagaaaggag agaugggcca gcccgggccg ccuggacacc ugggccccgc ugggccugaa     3300

ggagcccccg gcagcccugg cucccccggg cugccgggaa agcccggccc ucauggggau     3360

cuuggauuca aaggcaucaa ggggcuccug ggacccccug gcauucgcgg cccgcccggg     3420

cugccuggau uucccggcuc uccugggccc augggaauca gaggcgacca agggcgggau     3480

ggcaucccug gacccgcggg cgagaaaggg gaaaccggac uccugagagc cccgccuggc     3540

ccccgcggga acccuggagc ucagggcgcc aagggggacc ggggcgcucc cggauucccg     3600

ggccuuccug ggagaaaggg agccaugggc gaugcggggc cccgcggacc cacaggcauu     3660

gagggguuuc cuggaccccc uggccugccg ggcgccauca uucccgggca gaccggaaau     3720

agaggcccuc ccgggagccg gggauccccu ggcgcucccg ggccgccugg acccccuggc     3780

ucucacguca ucggcauuaa aggggacaag ggaagcaugg gccaccccgg gccuaaagga     3840

cccccgggca cagccggcga cauggggccc ccuggacgcc ucggcgcucc cgggacgccu     3900

ggacugcccg gcccuagagg ggauccggga uuccagggcu uucccggcgu gaagggggag     3960

aaaggaaacc cuggcuuccu gggguccauc ggacccccug gccccauugg gccgaaggga     4020

ccucccggcg uccggggcga cccugggacc cuuaagauca ucagccuccc cggaucuccg     4080

ggcccucccg ggacacccgg agaaccuggc augcaagggg agcccggacc uccggggccc     4140

ccuggcaacc ugggccccug uggaccucgc ggcaaacccg ggaaggaugg aaaaccuggc     4200

accccggggc ccgccggaga aaagggcaau aaaggcucca agggggagcc uggacccgcc     4260

ggcagcgacg ggcugccugg acucaaaggc aagagagggg auucuggauc ccccgcuaca     4320

uggaccacgc ggggcuucgu guuuacccgc cauagccaga caaccgcgau uccgucuugc     4380

cccgaaggca caguuccucu guacagcggg uucuccuuuc uuuucgugca gggaaaccag     4440

agagcccacg gccaagaccu ggggacccuc ggaagcugcc ugcagcgguu uacgacaaug     4500

cccuuccugu uuuguaaugu caacgaugug ugcaauuucg cuucucgcaa cgacuauucc     4560

uacuggcuua gcaccccugc ccugaugccc augaauaugg ccccuaucac aggcagagcu     4620

cucgagccgu auauuucccg guguaccguu ugcgaggggc ccgccaucgc gauugcugug     4680

cauucucaga ccacagauau cccucccugu ccucacggau ggaucagccu guggaagggc     4740

uuuuccuuca uuauguuuac gucugccggc agcgaaggga ccggacaggc ccucgcuucc     4800

cccggcucuu gccuggagga guucagagcc agcccguuuc uugaauguca ugggcgcgga     4860

acaugcaacu acuauuccaa uagcuacucu uucuggcugg cgucccucaa cccugagcgg     4920

auguucagaa aacccauccc uagcaccguc aaggcuggcg aacuggagaa aauuaucucu     4980

cgcugucaag ugugcaugaa gaaacggcac uga                                  5013


<210>  7560
<211>  5013
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Tumstatin__Homo_sapiens__CCDS42829.1

<400>  7560
augagugcuc ggacggcgcc aagaccucag guguuguugu ugccuuuacu uuuggucuua       60

uuggcagccg caccggcagc gucuaaaggc uguguuugua aagauaaggg gcagugcuuc      120

ugcgauggag cuaaagguga gaaaggagaa aaaggauuuc caggaccccc aggaucacca      180

gggcaaaaag guuucacggg cccugaagga uuaccugggc cacaaggucc gaaaggauuc      240

ccgggauuac cuggacuaac ugguucgaaa ggugucagag gaauaucagg acuuccagga      300

uuuucagguu cacccggacu uccaggaaca ccuggcaaca caggaccaua uggauuaguc      360

ggcguaccug gguguagugg aucuaaagga gagcaaggau uuccgggcuu gccaggaacu      420

uuaggcuauc caggcauacc uggagcagcu ggacugaaag gacaaaaagg ugcuccagca      480

aaagaagaag auauagaacu agaugccaaa ggagacccag gguuaccggg agcacccgga      540

ccacagggac uaccugggcc gccaggauuc ccaggaccag uagguccacc ugguccaccg      600

ggauuuuuug gguuuccagg cgcaaugggu ccucgagggc ccaaaggaca caugggcgaa      660

agagugauag gucacaaagg ggagagaggc guuaaggguu uaacaggccc accaggucca      720

ccagguacgg uaauuguaac acuaaccgga cccgauaaua ggacagauuu gaaaggagaa      780

aaaggagaca aaggcgcaau gggagaacca ggaccaccag gaccaagugg ccuaccugga      840

gaaaguuaug gaagcgaaaa gggagcacca ggagauccag gacuacaagg aaaaccaggg      900

aaagauggag ucccaggauu cccagggucc gaaggaguaa aggggaauag gggauuucca      960

ggacugaugg gagaagacgg aaucaaaggu caaaaaggug auauaggacc cccgggauuc     1020

agaggaccca cagaguauua cgauacauau caggaaaaag gcgacgaagg aacucccggu     1080

ccacccggac caagaggagc gaggggucca caaggaccau cuggaccacc aggaguucca     1140

gguucgccag gaaguucucg accaggacua agaggagcuc cuggguggcc aggguugaaa     1200

ggauccaagg gugagagagg gagaccaggc aaggacgcga uggguacacc aggaucgccg     1260

gggugcgcag gaucaccggg uuugccagga uccccaggcc caccgggacc acccggagau     1320

auaguauuca ggaaaggccc accgggggau cauggauuac caggauauuu ggggaguccu     1380

gguauccccg gaguugacgg gcccaaaggg gaaccaggac uuuuguguac acaaugucca     1440

uauauuccgg gucccccggg acuucccgga cuuccaggac uacauggcgu gaaagggaua     1500

ccagggcgac aaggugcagc cggccuaaaa ggaucaccgg gauccccagg aaauacuggu     1560

cucccagguu ucccaggauu uccuggagcg cagggagacc ccggauuaaa aggcgaaaaa     1620

ggagaaacuc uacagccuga aggacaagua ggaguuccug gagacccugg ucuuagagga     1680

caaccaggaa ggaaaggacu cgacgguaua cccgggaccc cgggaguuaa aggacuaccu     1740

ggucccaaag gugagcuugc acuuucugga gaaaagggcg aucagggacc gccaggagau     1800

cccgggaguc cagggucacc aggaccagcu gguccagcag gaccgccugg auacggucca     1860

caaggagagc cugggcuaca aggaacacaa ggggugccag gugcaccagg accuccuggg     1920

gaagcaggac cgagaggaga auuaagcgug ucuacuccag ugccaggacc uccaggacca     1980

ccggggccac cuggucaucc cgguccucaa ggacccccag gaaucccggg uucauuagga     2040

aaauguggug acccaggauu accuggacca gauggagaac cgggaauucc aggaauagga     2100

uuuccaggcc cuccaggacc uaaaggagac caagguuuuc caggaaccaa agguaguuua     2160

gguugcccag gaaaaauggg cgaaccaggu cuaccgggua aaccaggacu accuggcgcg     2220

aagggugaac cagcuguagc caugccgggu ggacccggaa caccugguuu uccgggcgaa     2280

cguggaaacu cgggagagca cggagagauu ggucucccag gauuaccagg acuaccaggc     2340

acaccaggua acgaaggacu ggauggucca cgcggugacc caggacaacc ugggccacca     2400

ggggaacaag gaccaccugg aagguguaua gaggguccca gaggcgcuca aggacuaccu     2460

ggauuaaaug guuuaaaggg ucagcaaggc agaagaggua aaacagggcc aaagggcgac     2520

ccagguauac ccggauugga cagaucuggu uuuccuggag aaacagguuc uccggguauu     2580

ccgggccacc aaggugaaau gggcccguua ggacagaggg guuacccugg uaaccccggg     2640

auccuagguc cgccuggaga ggauggugua auagggauga ugggauuucc uggagcuaua     2700

ggaccacccg gaccaccagg aaauccuggc acaccuggac agcgcggguc accaggaaua     2760

ccuggcguaa aaggccaaag aggaacccca ggggcaaaag gagaacaagg agacaaaggc     2820

aauccgggac cgucggaaau aucucaugua aucggagaca aaggugaacc cgggcuuaaa     2880

gguuuugccg gcaauccggg agaaaaagga aauagaggug ucccaggcau gccagguuua     2940

aaagguuuga aaggauuacc cggaccagcc gggccgccug guccgagagg agacuuaggg     3000

ucuacgggga acccaggaga accaggccuu agaggaauac cagguuccau gggaaauaug     3060

gggaugccug gaaguaaagg aaaaagaggu acguuagggu uucccggaag ggcuggacga     3120

ccgggauuac ccgggauaca uggucuucag ggagauaagg gagaaccagg auacucagaa     3180

gguacuagac cuggaccacc aggucccacg ggagacccgg gucuacccgg cgauauggga     3240

aaaaaaggag aaaugggcca accugguccg ccuggucauc ugggcccagc aggaccagag     3300

ggugcaccag gaagcccagg uucaccaggc cuaccgggaa aaccuggacc acauggugau     3360

uuaggauuua aaggaauaaa aggauuacua ggaccaccug gcauacgugg uccaccagga     3420

uugcccggcu uuccaggauc uccaggucca auggggauua gaggagauca agguagagac     3480

ggaauaccgg ggccagcggg ugaaaaagga gaaacagguu uauuacgagc uccgccagga     3540

ccgcggggga acccgggggc acaaggagca aaaggagaua gaggugcacc gggauuucca     3600

ggacugccag gucguaaagg agcgaugggg gaugccggac ccagaggccc uacggggaua     3660

gaaggcuucc ccgguccucc gggucuuccc ggugcaauaa uaccaggaca aacaggaaac     3720

cguggacccc cagggaguag agguucuccu ggagcaccag gaccuccggg accaccagga     3780

agucauguua ucggcauaaa gggcgacaaa ggcaguaugg gacauccagg accuaaagga     3840

ccuccaggua cagccggaga uaugggucca ccagggaggc uaggugcccc gggaacuccg     3900

ggacuuccag gacccagagg agauccagga uuucagggcu ucccuggagu uaaaggagaa     3960

aaaggcaauc cuggauucuu agggucuaua ggaccaccag ggccaauagg gccgaaagga     4020

ccaccaggag ugagaggaga cccuggaacc cuuaaaauaa uaaguuuacc cggauccccu     4080

gguccacccg ggacuccagg agaaccaggu augcaaggag aaccgggacc accaggcccg     4140

ccaggcaauc uagguccuug uggacccagg gggaaaccug ggaaggaugg aaagccagga     4200

accccaggac cggccgggga gaaagguaau aaagguagua aaggggagcc cggaccagca     4260

gggagcgacg gauuaccagg ccuaaagggu aaaagagggg acucagguuc accggcuacu     4320

uggacgacca gaggcuuugu guucacuaga cacucacaga cuacagcuau ucccucuugu     4380

ccagagggua cagucccacu auauaguggu uuuucauucc uuuuuguaca aggaaaucaa     4440

agggcacaug ggcaggaucu uggaacgcua gggucguguc ugcaaagauu cacuaccaug     4500

cccuuucuau uuuguaacgu caaugaugua uguaauuuug cgucaagaaa ugauuauagc     4560

uacugguugu caaccccugc auugaugccg augaacaugg cgcccaucac agguagagca     4620

cuagaaccgu acauaucuag auguacugua ugugaaggac cugcaaucgc aauugcagug     4680

cauucacaaa caacugauau uccuccaugc ccucacgggu ggauuucguu guggaaagga     4740

uucucauuca uaauguuuac aucugcggga ucagaaggaa caggucaagc acuugccucu     4800

ccgggaaguu guuuggagga auuucgcgca ucgccuuuuc uagaauguca ugguagagga     4860

acuuguaacu auuauagcaa uagcuacagc uuuuggcuag cuucauugaa uccggaaagg     4920

auguuuagaa aaccaauucc uucaacuguu aaagcaggug aauuggagaa aauaauuuca     4980

agaugccaag uguguaugaa aaagcgccac uaa                                  5013


<210>  7561
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Vasostatin__Homo_sapiens__P10645

<400>  7561

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
        115                 120                 125             


Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
    130                 135                 140                 


Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
145                 150                 155                 160 


Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 
            180                 185                 190         


Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
        195                 200                 205             


Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
    210                 215                 220                 


Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 
                245                 250                 255     


His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
            260                 265                 270         


Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
        275                 280                 285             


Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
    290                 295                 300                 


Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
305                 310                 315                 320 


Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                325                 330                 335     


Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
            340                 345                 350         


Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
        355                 360                 365             


Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
    370                 375                 380                 


Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 
385                 390                 395                 400 


Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
            420                 425                 430         


Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
        435                 440                 445             


His Gln Leu Gln Ala Leu Arg Arg Gly 
    450                 455         


<210>  7562
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Vasostatin__Homo_sapiens__AAH01059

<400>  7562
augcgcuccg ccgcuguccu ggcucuucug cucugcgccg ggcaagucac ugcgcucccu       60

gugaacagcc cuaugaauaa aggggauacc gaggugauga aaugcaucgu ugaggucauc      120

uccgacacac uuuccaagcc cagccccaug ccugucagcc aggaauguuu ugagacacuc      180

cgaggagaug aacggauccu uuccauucug agacaucaga auuuacugaa ggagcuccaa      240

gaccucgcuc uccaaggcgc caaggagagg gcacaucagc agaagaaaca cagcgguuuu      300

gaagaugaac ucucagaggu ucuugagaac cagagcagcc aggccgagcu gaaagaggcg      360

guggaagagc caucauccaa ggauguuaug gagaaaagag aggauuccaa ggaggcagag      420

aaaaguggug aagccacaga cggagccagg ccccaggccc ucccggagcc caugcaggag      480

uccaaggcug aggggaacaa ucaggccccu ggggaggaag aggaggagga ggaggaggcc      540

accaacaccc acccuccagc cagccucccc agccagaaau acccaggccc acaggccgag      600

ggggacagug agggccucuc ucagggucug guggacagag agaagggccu gagugcagag      660

ccaggguggc aggcaaagag agaagaggag gaggaggagg aggaggaggc ugaggcugga      720

gaggaggcug uccccgagga agaaggcccc acuguagugc ugaaccccca cccgagccuu      780

ggcuacaagg agauccggaa aggcgagagu cggucggagg cucuggcugu ggauggagcu      840

gggaagccug gggcugagga ggcucaggac cccgaaggga agggagaaca ggagcacucc      900

cagcagaaag aggaggagga ggagauggca guggucccgc aaggccucuu ccgggguggg      960

aagagcggag agcuggagca ggaggaggag cggcucucca aggaguggga ggacuccaaa     1020

cgcuggagca agauggacca gcuggccaag gagcugacgg cugagaagcg gcuggagggg     1080

caggaggagg aggaggacaa ccgggacagu uccaugaagc ucuccuuccg ggcccgggcc     1140

uacggcuuca ggggcccugg gccgcagcug cgacgaggcu ggaggccauc cucccgggag     1200

gacagccuug aggcgggccu gccccuccag guccgaggcu accccgagga gaagaaagag     1260

gaggagggca gcgcaaaccg cagaccagag gaccaggagc uggagagccu gucggccauu     1320

gaggcagagc uggagaaagu ggcccaccag cugcaggcac uacggcgggg cuga           1374


<210>  7563
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7563
augcgcagcg ccgccgugcu ggcgcuccug cugugcgccg gccaggucac cgcccucccc       60

gugaacuccc cgaugaacaa gggggacacc gaggugauga agugcaucgu cgaggugauc      120

agcgacacgc uguccaagcc cagccccaug cccguguccc aggagugcuu cgagacccug      180

cggggcgacg agcgcauccu cagcauccug cggcaccaga accugcucaa ggagcugcag      240

gaccuggccc uccagggggc caaggagcgc gcgcaccagc agaagaagca cuccggcuuc      300

gaggacgagc ugagcgaggu ccuggagaac caguccagcc aggccgagcu caaggaggcc      360

guggaggagc cguccagcaa ggacgugaug gagaagcggg aggacuccaa ggaggccgag      420

aaguccgggg aggcgaccga cggcgcccgc ccccaggccc ugcccgagcc caugcaggag      480

agcaaggccg agggcaacaa ccaggccccg ggggaggagg aggaggagga ggaggaggcg      540

accaacacgc acccgcccgc cagccugccc ucccagaagu accccggccc ccaggccgag      600

ggggacagcg agggccucuc ccaggggcug gucgaccggg agaagggccu gagcgccgag      660

cccggcuggc aggccaagcg cgaggaggag gaggaggagg aggaggaggc ggaggccggg      720

gaggaggccg ugcccgagga ggagggcccg accguggucc ucaaccccca ccccagccug      780

ggguacaagg agauccggaa gggcgagucc cgcagcgagg cccuggccgu ggacggcgcg      840

gggaagcccg gcgccgagga ggcccaggac ccggagggga agggcgagca ggagcacucc      900

cagcagaagg aggaggagga ggagauggcc gugguccccc aggggcuguu ccggggcggc      960

aagagcgggg agcuggagca ggaggaggag cgccugucca aggaguggga ggacagcaag     1020

cgguggucca agauggacca gcucgccaag gagcugaccg cggagaagcg ccuggagggc     1080

caggaggagg aggaggacaa ccgggacagc uccaugaagc ucagcuuccg cgcccgggcc     1140

uacggguucc gcggccccgg gccccagcug cggcgcggcu ggcggccguc cagccgcgag     1200

gacucccugg aggccggccu cccccuccag gugcgcgggu accccgagga gaagaaggag     1260

gaggagggca gcgcgaaccg gcgccccgag gaccaggagc uggagucccu cagcgccauc     1320

gaggccgagc uggagaaggu ggcccaccag cugcaggccc uccggcgcgg guga           1374


<210>  7564
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7564
augcgcuccg ccgccguccu cgcccuccuc cucugcgccg gccaggucac cgcccucccc       60

gucaacuccc ccaugaacaa gggcgacacc gaggucauga agugcaucgu cgaggucauc      120

uccgacaccc ucuccaagcc cucccccaug cccgucuccc aggagugcuu cgagacccuc      180

cgcggcgacg agcgcauccu cuccauccuc cgccaccaga accuccucaa ggagcuccag      240

gaccucgccc uccagggcgc caaggagcgc gcccaccagc agaagaagca cuccggcuuc      300

gaggacgagc ucuccgaggu ccucgagaac caguccuccc aggccgagcu caaggaggcc      360

gucgaggagc ccuccuccaa ggacgucaug gagaagcgcg aggacuccaa ggaggccgag      420

aaguccggcg aggccaccga cggcgcccgc ccccaggccc uccccgagcc caugcaggag      480

uccaaggccg agggcaacaa ccaggccccc ggcgaggagg aggaggagga ggaggaggcc      540

accaacaccc acccccccgc cucccucccc ucccagaagu accccggccc ccaggccgag      600

ggcgacuccg agggccucuc ccagggccuc gucgaccgcg agaagggccu cuccgccgag      660

cccggcuggc aggccaagcg cgaggaggag gaggaggagg aggaggaggc cgaggccggc      720

gaggaggccg uccccgagga ggagggcccc accgucgucc ucaaccccca ccccucccuc      780

ggcuacaagg agauccgcaa gggcgagucc cgcuccgagg cccucgccgu cgacggcgcc      840

ggcaagcccg gcgccgagga ggcccaggac cccgagggca agggcgagca ggagcacucc      900

cagcagaagg aggaggagga ggagauggcc gucguccccc agggccucuu ccgcggcggc      960

aaguccggcg agcucgagca ggaggaggag cgccucucca aggaguggga ggacuccaag     1020

cgcuggucca agauggacca gcucgccaag gagcucaccg ccgagaagcg ccucgagggc     1080

caggaggagg aggaggacaa ccgcgacucc uccaugaagc ucuccuuccg cgcccgcgcc     1140

uacggcuucc gcggccccgg cccccagcuc cgccgcggcu ggcgccccuc cucccgcgag     1200

gacucccucg aggccggccu cccccuccag guccgcggcu accccgagga gaagaaggag     1260

gaggagggcu ccgccaaccg ccgccccgag gaccaggagc ucgagucccu cuccgccauc     1320

gaggccgagc ucgagaaggu cgcccaccag cuccaggccc uccgccgcgg cuga           1374


<210>  7565
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7565
augagaagcg ccgcugugcu ggcacuccuu cugugcgccg gccaggucac cgcguugccc       60

guuaacuccc cuaugaauaa gggggacaca gaggugauga aauguaucgu agaagugauu      120

ucugauacuu uaucaaagcc aaguccgaug cccgucagcc aagagugcuu cgaaacgcug      180

aggggagacg agcggauacu auccauccuc cgccaccaga accugcuuaa agaacugcag      240

gauuuggcuc uccagggugc caaggagcga gcacaucaac agaaaaagca cucuggcuuu      300

gaggacgaac ugucggaggu gcuggaaaau cagucaagcc aggccgagcu caaggaggcu      360

guugaggagc cuaguuccaa agaugugaug gaaaagcgug aggacucuaa agaagcagaa      420

aagagcgggg aggccaccga uggagcuaga ccacaagccu uacccgaacc uaugcaggag      480

uccaaagcgg aaggcaacaa ucaggcacca ggugaggaag aggaggaaga ggaagaggcc      540

acaaacacuc aucccccugc uucacugcca agucagaagu acccggggcc ccaagccgaa      600

ggagacagcg agggccuuuc ucagggcuug gucgauaggg agaaggggcu guccgcagaa      660

ccuggauggc aggcuaaacg ggaggaagag gaggaagagg aagaggaagc cgaggcgggu      720

gaggaagccg ugccagagga agagggcccc accguaguuc uaaauccuca cccaucacuc      780

ggguauaagg aaauucgcaa aggagagagc agaagugagg cacuggcugu ggacggcgcc      840

gguaagcccg gggcugaaga ggcccaagau ccggaaggaa aaggcgagca ggaacauucu      900

cagcagaagg aggaggaaga ggaaauggca gucgugccuc aaggccuuuu caggggaggg      960

aaauccggug agcuggagca ggaagaggaa cgguugagca aggaguggga agacucgaag     1020

cgcuggucua aaauggauca gcucgccaag gagcugacag cugagaaacg auuagaaggc     1080

caggaggaag aggaagacaa cagagacucc ucaaugaagc ugaguuuuag ggcgcgggca     1140

uacggguucc guggacccgg cccacaacuc cgcagagguu ggaggccuag cucccgggag     1200

gauucucuug aggccgggcu gccccuacag gugcgaggcu auccagaaga gaaaaaggaa     1260

gaggaaggaa gcgcuaaucg cagacccgag gaccaggagu uggaaucacu gagugccauc     1320

gaggcagaac ucgagaaggu cgcccaccag cugcaagcuc uuaggcgggg cuga           1374


<210>  7566
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7566
augagaagcg ccgccgugcu ggcccugcug cugugcgccg gccaggugac cgcccugccc       60

gugaacagcc ccaugaacaa gggcgacacc gaggugauga agugcaucgu ggaggugauc      120

agcgacaccc ugagcaagcc cagccccaug cccgugagcc aggagugcuu cgagacccug      180

agaggcgacg agagaauccu gagcauccug agacaccaga accugcugaa ggagcugcag      240

gaccuggccc ugcagggcgc caaggagaga gcccaccagc agaagaagca cagcggcuuc      300

gaggacgagc ugagcgaggu gcuggagaac cagagcagcc aggccgagcu gaaggaggcc      360

guggaggagc ccagcagcaa ggacgugaug gagaagagag aggacagcaa ggaggccgag      420

aagagcggcg aggccaccga cggcgccaga ccccaggccc ugcccgagcc caugcaggag      480

agcaaggccg agggcaacaa ccaggccccc ggcgaggagg aggaggagga ggaggaggcc      540

accaacaccc acccccccgc cagccugccc agccagaagu accccggccc ccaggccgag      600

ggcgacagcg agggccugag ccagggccug guggacagag agaagggccu gagcgccgag      660

cccggcuggc aggccaagag agaggaggag gaggaggagg aggaggaggc cgaggccggc      720

gaggaggccg ugcccgagga ggagggcccc accguggugc ugaaccccca ccccagccug      780

ggcuacaagg agaucagaaa gggcgagagc agaagcgagg cccuggccgu ggacggcgcc      840

ggcaagcccg gcgccgagga ggcccaggac cccgagggca agggcgagca ggagcacagc      900

cagcagaagg aggaggagga ggagauggcc guggugcccc agggccuguu cagaggcggc      960

aagagcggcg agcuggagca ggaggaggag agacugagca aggaguggga ggacagcaag     1020

agauggagca agauggacca gcuggccaag gagcugaccg ccgagaagag acuggagggc     1080

caggaggagg aggaggacaa cagagacagc agcaugaagc ugagcuucag agccagagcc     1140

uacggcuuca gaggccccgg cccccagcug agaagaggcu ggagacccag cagcagagag     1200

gacagccugg aggccggccu gccccugcag gugagaggcu accccgagga gaagaaggag     1260

gaggagggca gcgccaacag aagacccgag gaccaggagc uggagagccu gagcgccauc     1320

gaggccgagc uggagaaggu ggcccaccag cugcaggccc ugagaagagg cuga           1374


<210>  7567
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7567
augagaagcg ccgcugugcu ggcccuccug cuuugcgcgg gccaggucac cgcucugccc       60

guuaacuccc cuaugaauaa gggggacaca gaggugauga aauguaucgu ggaagucauu      120

ucugauacgc ucagcaagcc gucccccaug ccugugucuc aagagugcuu cgaaacccug      180

cggggagacg agcgcauccu uagcauucug agacaccaga accuccugaa agaacugcag      240

gaucucgccc ugcagggcgc caaggagcgg gcucaucaac agaaaaagca cuccggguuu      300

gaggacgaac uuucugaggu ucuggaaaau cagagcuccc aggccgagcu caaggaggcu      360

guggaggagc ccagcucuaa agaugucaug gaaaagcgcg aggacuccaa agaagccgaa      420

aagagcggag aggcgacaga uggcgccaga ccucaagcuc ugcccgaacc uaugcaggag      480

ucuaaagccg aagggaacaa ucaggcuccg ggagaggaag aggaggaaga ggaagaggcc      540

accaacacac aucccccugc gucccuuccc agccagaagu acccuggccc ccaagccgaa      600

ggcgacucug aggggcuguc ccagggacuc guggaucggg agaagggccu gagcgcugaa      660

ccgggguggc aggccaaacg cgaggaagag gaggaagagg aagaggaagc ugaggccgga      720

gaggaagccg uuccugagga agagggcccc accguggucc ugaauccuca ccccucccuc      780

ggguauaagg aaaucagaaa aggagagucu cggagcgagg cucuggcggu ggacggcgcc      840

ggcaagcccg gggcugaaga ggcccaagau ccugaaggaa aaggcgagca ggaacauucc      900

cagcagaagg aggaggaaga ggaaauggcc guggucccgc aagggcuuuu ccgcggaggc      960

aaaagcgggg agcuggagca ggaagaggaa agacucucua aggaguggga agacuccaag     1020

cgguggagca aaauggauca gcuggcuaag gagcuuacag ccgagaaacg ccuggaagga     1080

caggaggaag aggaagacaa cagagacucu agcaugaagc ucuccuuucg ggcgcgcgcu     1140

uacggcuuca gaggccccgg gccucaacug cggagaggau ggcgccccuc uagccgggag     1200

gauucccugg aggccggccu cccucugcag guuagagggu aucccgaaga gaaaaaggaa     1260

gaggaaggaa gcgccaaucg ccggccggag gaccaggagc uugaaucucu guccgcuauu     1320

gaggccgaac ucgagaaggu ggcucaccag cugcaagccc uuagacgcgg cuga           1374


<210>  7568
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Vasostatin__Homo_sapiens__AAH01059

<400>  7568
augagaucag cagcaguauu agcauuauua uuaugugcag gacagguaac ggcacugcca       60

gugaauuccc caaugaauaa aggagauaca gaaguaauga aauguauagu agaaguaaua      120

agcgauacau uaagcaaacc caguccaaug ccaguaucac aagaauguuu ugaaacauua      180

agaggugaug aaagaauauu aaguauacuu agacaucaaa aucuauuaaa agaauuacaa      240

gauuuagcac uacagggagc aaaagaaaga gcacaucaac aaaagaaaca cagugguuuc      300

gaagaugaau uaucagaagu guuagaaaau caaaguucac aagcagaacu aaaagaggca      360

guggaagaac caaguagcaa agauguaaug gaaaagaggg aagauaguaa agaggcggaa      420

aaaaguggag aagcgacgga uggagcucga ccacaagcau uaccagaacc uaugcaggaa      480

aguaaagcgg aaggaaacaa ucaagcacca ggagaggaag aagaagaaga agaagaagcu      540

acaaauacac auccuccagc gagccuaccg agucaaaaau auccuggacc acaggcagaa      600

ggagauucag aaggauuaag ucaaggacuu guagauagag aaaaaggacu aagugcugaa      660

cccgguuggc aagcaaaaag ggaagaagaa gaagaagaag aagaagaagc agaagcagga      720

gaagaagcag uaccggaaga agaaggacca acggucgugc uaaauccaca uccaaguuua      780

ggauacaaag aaauaagaaa aggagaaagc agaagugagg cauuagcugu agauggugca      840

ggaaaaccgg gagcugaaga agcucaagac ccagaaggaa aaggagaaca agaacauagc      900

caacaaaagg aagaagaaga agaaauggcu guaguaccac aaggacuauu cagaggagga      960

aaaagcggag aauuagagca agaagaagaa agauuaagua aagaauggga agauaguaaa     1020

agauggagua aaauggauca auuagcaaaa gaacucacgg cagaaaaaag acuagaagga     1080

caagaagaag aagaagacaa cagagauagu ucaaugaaac uaaguuuuag agcaagagcg     1140

uacggauuua ggggaccagg gccacaacua aggaggggau ggagaccauc aaguagagaa     1200

gauaguuuag aagcaggauu accuuuacaa guaagaggau auccagaaga aaaaaaagaa     1260

gaagaaggaa gcgcgaacag gagaccagaa gaucaagaau uggagagccu aagugcaaua     1320

gaagcagagu uagaaaaggu agcacaucaa uugcaagcau uacgaagagg auga           1374


<210>  7569
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__B4DHR1

<400>  7569

Met Leu Leu Ser Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
1               5                   10                  15      


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
            20                  25                  30          


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
        35                  40                  45              


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
    50                  55                  60                  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
65                  70                  75                  80  


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
                85                  90                  95      


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
            100                 105                 110         


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
        115                 120                 125             


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
    130                 135                 140                 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
145                 150                 155                 160 


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
                165                 170                 175     


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
            180                 185                 190         


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
        195                 200                 205             


Ile Asp Asp Pro 
    210         


<210>  7570
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__BAG58223

<400>  7570
augcugcuau ccgucuacuu caaggagcag uuucuggacg gagacgggug gacuucccgc       60

uggaucgaau ccaaacacaa gucagauuuu ggcaaauucg uucucaguuc cggcaaguuc      120

uacggugacg aggagaaaga uaaagguuug cagacaagcc aggaugcacg cuuuuaugcu      180

cugucggcca guuucgagcc uuucagcaac aaaggccaga cgcugguggu gcaguucacg      240

gugaaacaug agcagaacau cgacuguggg ggcggcuaug ugaagcuguu uccuaauagu      300

uuggaccaga cagacaugca cggagacuca gaauacaaca ucauguuugg ucccgacauc      360

uguggcccug gcaccaagaa gguucauguc aucuucaacu acaagggcaa gaacgugcug      420

aucaacaagg acauccguug caaggaugau gaguuuacac accuguacac acugauugug      480

cggccagaca acaccuauga ggugaagauu gacaacagcc agguggaguc cggcuccuug      540

gaagacgauu gggacuuccu gccacccaag aagauaaagg auccugaugc uucaaaaccg      600

gaagacuggg augagcgggc caagaucgau gaucccuga                             639


<210>  7571
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7571
augcugcuca gcguguacuu caaggagcag uuccuggacg gcgacgggug gaccucccgc       60

uggaucgaga gcaagcacaa guccgacuuc ggcaaguucg uccugagcuc cgggaaguuc      120

uacggcgacg aggagaagga caaggggcuc cagaccagcc aggacgcccg guucuacgcc      180

cuguccgcga gcuucgagcc cuucuccaac aagggccaga cgcugguggu gcaguucacc      240

gucaagcacg agcagaacau cgacugcggc gggggcuacg ugaagcuguu cccgaacagc      300

cucgaccaga ccgacaugca cggggacucc gaguacaaca ucauguucgg ccccgacauc      360

ugcgggcccg gcaccaagaa ggugcacguc aucuucaacu acaagggcaa gaacgugcug      420

aucaacaagg acauccgcug caaggacgac gaguucacgc accucuacac ccugaucgug      480

cggcccgaca acaccuacga ggucaagauc gacaacagcc agguggaguc cgggagccug      540

gaggacgacu gggacuuccu cccgcccaag aagaucaagg accccgacgc cuccaagccc      600

gaggacuggg acgagcgcgc caagaucgac gacccguga                             639


<210>  7572
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7572
augcuccucu ccgucuacuu caaggagcag uuccucgacg gcgacggcug gaccucccgc       60

uggaucgagu ccaagcacaa guccgacuuc ggcaaguucg uccucuccuc cggcaaguuc      120

uacggcgacg aggagaagga caagggccuc cagaccuccc aggacgcccg cuucuacgcc      180

cucuccgccu ccuucgagcc cuucuccaac aagggccaga cccucgucgu ccaguucacc      240

gucaagcacg agcagaacau cgacugcggc ggcggcuacg ucaagcucuu ccccaacucc      300

cucgaccaga ccgacaugca cggcgacucc gaguacaaca ucauguucgg ccccgacauc      360

ugcggccccg gcaccaagaa gguccacguc aucuucaacu acaagggcaa gaacguccuc      420

aucaacaagg acauccgcug caaggacgac gaguucaccc accucuacac ccucaucguc      480

cgccccgaca acaccuacga ggucaagauc gacaacuccc aggucgaguc cggcucccuc      540

gaggacgacu gggacuuccu cccccccaag aagaucaagg accccgacgc cuccaagccc      600

gaggacuggg acgagcgcgc caagaucgac gaccccuga                             639


<210>  7573
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7573
augcugcuca gcguguacuu caaggagcag uuucuugacg gcgaugggug gaccuccaga       60

uggaucgaau cuaaacacaa gucagacuuc ggaaaauuug uccugaguag cgguaaguuc      120

uauggcgaug aggaaaaaga caagggguug caaacauccc aggaugccag guuuuacgcu      180

uuaucugcau cguucgagcc cuuuucaaac aagggacaga cucugguugu gcaguucacg      240

guaaaacaug aacaaaauau ugacugcggc gguggguaug ugaagcuauu uccuaacagc      300

cucgaucaga ccgacaugca cggagauagu gaguacaaua uaauguucgg cccagacauc      360

uguggcccgg ggacuaaaaa gguccaugug auuuuuaacu auaaaggaaa gaauguucug      420

aucaacaagg auauucggug caaagacgau gaguucacac accuuuacac ccugaucgug      480

cgccccgaca auacauauga agucaagaua gacaacuccc agguggaguc ugguagcuug      540

gaagaugacu gggauuuucu cccucccaaa aagaucaaag acccagaugc cuccaagccu      600

gaggacuggg augagcgagc gaaaauugac gauccauga                             639


<210>  7574
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7574
augcugcuga gcguguacuu caaggagcag uuccuggacg gcgacggcug gaccagcaga       60

uggaucgaga gcaagcacaa gagcgacuuc ggcaaguucg ugcugagcag cggcaaguuc      120

uacggcgacg aggagaagga caagggccug cagaccagcc aggacgccag auucuacgcc      180

cugagcgcca gcuucgagcc cuucagcaac aagggccaga cccugguggu gcaguucacc      240

gugaagcacg agcagaacau cgacugcggc ggcggcuacg ugaagcuguu ccccaacagc      300

cuggaccaga ccgacaugca cggcgacagc gaguacaaca ucauguucgg ccccgacauc      360

ugcggccccg gcaccaagaa ggugcacgug aucuucaacu acaagggcaa gaacgugcug      420

aucaacaagg acaucagaug caaggacgac gaguucaccc accuguacac ccugaucgug      480

agacccgaca acaccuacga ggugaagauc gacaacagcc agguggagag cggcagccug      540

gaggacgacu gggacuuccu gccccccaag aagaucaagg accccgacgc cagcaagccc      600

gaggacuggg acgagagagc caagaucgac gaccccuga                             639


<210>  7575
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7575
augcugcuca gcguguacuu caaggagcag uuucuggacg gcgaugggug gaccuccaga       60

uggaucgaau cuaaacacaa gagcgacuuc ggaaaauuug uccuuuccuc uggcaaguuc      120

uauggggaug aggaaaaaga caagggacug caaacaagcc aggaugcccg guuuuacgcu      180

cucuccgccu cuuucgagcc cuuuagcaac aagggccaga cgcugguugu gcaguucacc      240

gugaaacaug aacaaaauau ugacugcggg ggaggcuaug ucaaacuuuu uccuaacucc      300

cuggaucaga cagacaugca cggcgauagc gaguacaaua ucauguucgg gccggacauu      360

uguggacccg gcaccaagaa ggugcauguu aucuuuaacu auaaagggaa gaaugugcuc      420

auuaacaagg auauccgcug caaagacgau gaguucacac accuguacac ccugaucguc      480

agaccugaca auacauauga agugaagauu gacaacucuc agguugaguc cggaagccuc      540

gaagaugacu gggauuuucu gcccccuaaa aagaucaaag accccgaugc gucuaagccu      600

gaggacuggg augagcgggc uaaaauugac gauccguga                             639


<210>  7576
<211>  639
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       calreticulin__Homo_sapiens__BAG58223

<400>  7576
augcuacuaa gcguauacuu caaagaacaa uuccuagacg gagacggaug gacaucaaga       60

uggaucgaau caaaacacaa aucagacuuc ggaaaauucg uacuaucauc aggaaaauuu      120

uacggagacg aagaaaaaga caaaggacuc caaacaucac aagacgcaag auucuacgca      180

cuaucagcau cauucgaacc auucucaaac aaaggacaaa cacuagucgu acaauucaca      240

guaaaacacg aacaaaacau agacugcgga ggaggauacg uaaaacuauu cccaaacuca      300

cuagaccaaa cagauaugca cggagacagc gaauacaaca uaauguucgg accagacaua      360

ugcggaccag gaacaaaaaa aguacacgua auauucaacu acaaaggaaa aaacguacua      420

auaaacaaag acauaagaug caaagacgac gaauucacac accuauacac acuaauagua      480

agaccagaua acacauacga agucaaaaua gacaacucac aaguagaauc aggauccuua      540

gaagacgacu gggacuuccu accaccaaaa aaaauaaaag acccagacgc aucaaaacca      600

gaagacuggg acgaaagagc aaaaauagac gacccauaa                             639


<210>  7577
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__B4E2Y9

<400>  7577

Met His Gly Asp Ser Glu Tyr Asn Ile Met Phe Gly Pro Asp Ile Cys 
1               5                   10                  15      


Gly Pro Gly Thr Lys Lys Val His Val Ile Phe Asn Tyr Lys Gly Lys 
            20                  25                  30          


Asn Val Leu Ile Asn Lys Asp Ile Arg Cys Lys Asp Asp Glu Phe Thr 
        35                  40                  45              


His Leu Tyr Thr Leu Ile Val Arg Pro Asp Asn Thr Tyr Glu Val Lys 
    50                  55                  60                  


Ile Asp Asn Ser Gln Val Glu Ser Gly Ser Leu Glu Asp Asp Trp Asp 
65                  70                  75                  80  


Phe Leu Pro Pro Lys Lys Ile Lys Asp Pro Asp Ala Ser Lys Pro Glu 
                85                  90                  95      


Asp Trp Asp Glu Arg Ala Lys Ile Asp Asp Pro Thr Asp Ser Lys Pro 
            100                 105                 110         


Glu Asp Trp Asp Lys Pro Glu His Ile Pro Asp Pro Asp Ala Lys Lys 
        115                 120                 125             


Pro Glu Asp Trp Asp Glu Glu Met Asp Gly Glu Trp Glu Pro Pro Val 
    130                 135                 140                 


Ile Gln Asn Pro Glu Tyr Lys Gly Glu Trp Lys Pro Arg Gln Ile Asp 
145                 150                 155                 160 


Asn Pro Asp Tyr Lys Gly Thr Trp Ile His Pro Glu Ile Asp Asn Pro 
                165                 170                 175     


Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr Asp Asn Phe Gly Val 
            180                 185                 190         


Leu Gly Leu Asp Leu Trp Gln Val Lys Ser Gly Thr Ile Phe Asp Asn 
        195                 200                 205             


Phe Leu Ile Thr Asn Asp Glu Ala Tyr Ala Glu Glu Phe Gly Asn Glu 
    210                 215                 220                 


Thr Trp Gly Val Thr Lys Ala Ala Glu Lys Gln Met Lys Asp Lys Gln 
225                 230                 235                 240 


Asp Glu Glu Gln Arg Leu Lys Glu Glu Glu Glu Asp Lys Lys Arg Lys 
                245                 250                 255     


Glu Glu Glu Glu Ala Glu Asp Lys Glu Asp Asp Glu Asp Lys Asp Glu 
            260                 265                 270         


Asp Glu Glu Asp Glu Glu Asp Lys Glu Glu Asp Glu Glu Glu Asp Val 
        275                 280                 285             


Pro Gly Gln Ala Lys Asp Glu Leu 
    290                 295     


<210>  7578
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__BAG65301

<400>  7578
augcacggag acucagaaua caacaucaug uuuggucccg acaucugugg cccuggcacc       60

aagaagguuc augucaucuu caacuacaag ggcaagaacg ugcugaucaa caaggacauc      120

cguugcaagg augaugaguu uacacaccug uacacacuga uugugcggcc agacaacacc      180

uaugagguga agauugacaa cagccaggug gaguccggcu ccuuggaaga cgauugggac      240

uuccugccac ccaagaagau aaaggauccu gaugcuucaa aaccggaaga cugggaugag      300

cgggccaaga ucgaugaucc cacagacucc aagccugagg acugggacaa gcccgagcau      360

aucccugacc cugaugcuaa gaagcccgag gacugggaug aagagaugga cggagagugg      420

gaacccccag ugauucagaa cccugaguac aagggugagu ggaagccccg gcagaucgac      480

aacccagauu acaagggcac uuggauccac ccagaaauug acaaccccga guauucuccc      540

gaucccagua ucuaugccua ugauaacuuu ggcgugcugg gccuggaccu cuggcagguc      600

aagucuggca ccaucuuuga caacuuccuc aucaccaacg augaggcaua cgcugaggag      660

uuuggcaacg agacgugggg cguaacaaag gcagcagaga aacaaaugaa ggacaaacag      720

gacgaggagc agaggcuuaa ggaggaggaa gaagacaaga aacgcaaaga ggaggaggag      780

gcagaggaca aggaggauga ugaggacaaa gaugaggaug aggaggauga ggaggacaag      840

gaggaagaug aggaggaaga uguccccggc caggccaagg acgagcugua g               891


<210>  7579
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7579
augcacggcg acagcgagua caacaucaug uucgggcccg acaucugcgg cccggggacc       60

aagaaggugc acgucaucuu caacuacaag ggcaagaacg ugcugaucaa caaggacauc      120

cgcugcaagg acgacgaguu cacccaccuc uacacgcuga ucgugcggcc cgacaacacc      180

uacgagguca agaucgacaa cucccaggug gagagcgggu cccuggagga cgacugggac      240

uuccucccgc ccaagaagau caaggacccc gacgccagca agcccgagga cugggacgag      300

cgcgccaaga ucgacgaccc caccgacucc aagcccgagg acugggacaa gccggagcac      360

auccccgacc ccgacgcgaa gaagcccgag gacugggacg aggagaugga cggcgagugg      420

gagccgcccg ugauccagaa ccccgaguac aagggcgagu ggaagccccg gcagaucgac      480

aacccggacu acaaggggac cuggauccac cccgagaucg acaaccccga guacagcccc      540

gacccgucca ucuacgccua cgacaacuuc ggcguccugg ggcuggaccu cuggcagguc      600

aagagcggca cgaucuucga caacuuccug aucaccaacg acgaggccua cgccgaggag      660

uucgggaacg agaccugggg cgugaccaag gccgcggaga agcagaugaa ggacaagcag      720

gacgaggagc agcgccugaa ggaggaggag gaggacaaga agcggaagga ggaggaggag      780

gccgaggaca aggaggacga cgaggacaag gacgaggacg aggaggacga ggaggacaag      840

gaggaggacg aggaggagga cgugcccggc caggccaagg acgagcucug a               891


<210>  7580
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7580
augcacggcg acuccgagua caacaucaug uucggccccg acaucugcgg ccccggcacc       60

aagaaggucc acgucaucuu caacuacaag ggcaagaacg uccucaucaa caaggacauc      120

cgcugcaagg acgacgaguu cacccaccuc uacacccuca ucguccgccc cgacaacacc      180

uacgagguca agaucgacaa cucccagguc gaguccggcu cccucgagga cgacugggac      240

uuccuccccc ccaagaagau caaggacccc gacgccucca agcccgagga cugggacgag      300

cgcgccaaga ucgacgaccc caccgacucc aagcccgagg acugggacaa gcccgagcac      360

auccccgacc ccgacgccaa gaagcccgag gacugggacg aggagaugga cggcgagugg      420

gagccccccg ucauccagaa ccccgaguac aagggcgagu ggaagccccg ccagaucgac      480

aaccccgacu acaagggcac cuggauccac cccgagaucg acaaccccga guacuccccc      540

gaccccucca ucuacgccua cgacaacuuc ggcguccucg gccucgaccu cuggcagguc      600

aaguccggca ccaucuucga caacuuccuc aucaccaacg acgaggccua cgccgaggag      660

uucggcaacg agaccugggg cgucaccaag gccgccgaga agcagaugaa ggacaagcag      720

gacgaggagc agcgccucaa ggaggaggag gaggacaaga agcgcaagga ggaggaggag      780

gccgaggaca aggaggacga cgaggacaag gacgaggacg aggaggacga ggaggacaag      840

gaggaggacg aggaggagga cguccccggc caggccaagg acgagcucug a               891


<210>  7581
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7581
augcacggcg acagcgagua caacaucaug uucgggcccg auauuugcgg accugguacc       60

aagaaagugc augucauauu uaauuauaag ggcaaaaacg uucugaucaa uaaggacauu      120

agauguaaag augacgaauu uacacaccuc uacacucuua ucgugaggcc agauaacacg      180

uaugagguaa agauugacaa uucccaggug gaaucugggu cacuggagga ugacugggau      240

uucuugccgc ccaagaaaau caaggacccu gaugccagua aaccagaaga cugggaugag      300

cgggcuaaga uagacgaccc caccgauagc aaaccugagg acugggauaa gccagaacau      360

auccccgacc cugaugcaaa gaaaccagag gacugggaug aagagaugga cggagagugg      420

gaaccgcccg ucauucaaaa cccugaguac aagggcgaau ggaaaccacg ccagaucgau      480

aaucccgacu auaaggguac auggauucac ccugagaucg auaacccaga auacuccccc      540

gacccgucua uauaugccua cgacaauuuc gggguguuag gacuggaucu auggcagguu      600

aaaucgggca cuauuuuuga caacuuccuc aucaccaaug augaggcgua cgcugaggaa      660

uuuggcaacg agacaugggg agugaccaag gccgcagaaa aacagaugaa ggacaagcaa      720

gaugaggaac agcgacugaa agaggaggaa gaggacaaga aacguaagga agaggaagag      780

gccgaggaua aagaagacga ugaggacaag gaugaagacg aggaggauga agaggacaag      840

gaagaggacg aagaggagga ugucccuggg caggcuaaag acgaacuuug a               891


<210>  7582
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7582
augcacggcg acagcgagua caacaucaug uucggccccg acaucugcgg ccccggcacc       60

aagaaggugc acgugaucuu caacuacaag ggcaagaacg ugcugaucaa caaggacauc      120

agaugcaagg acgacgaguu cacccaccug uacacccuga ucgugagacc cgacaacacc      180

uacgagguga agaucgacaa cagccaggug gagagcggca gccuggagga cgacugggac      240

uuccugcccc ccaagaagau caaggacccc gacgccagca agcccgagga cugggacgag      300

agagccaaga ucgacgaccc caccgacagc aagcccgagg acugggacaa gcccgagcac      360

auccccgacc ccgacgccaa gaagcccgag gacugggacg aggagaugga cggcgagugg      420

gagccccccg ugauccagaa ccccgaguac aagggcgagu ggaagcccag acagaucgac      480

aaccccgacu acaagggcac cuggauccac cccgagaucg acaaccccga guacagcccc      540

gaccccagca ucuacgccua cgacaacuuc ggcgugcugg gccuggaccu guggcaggug      600

aagagcggca ccaucuucga caacuuccug aucaccaacg acgaggccua cgccgaggag      660

uucggcaacg agaccugggg cgugaccaag gccgccgaga agcagaugaa ggacaagcag      720

gacgaggagc agagacugaa ggaggaggag gaggacaaga agagaaagga ggaggaggag      780

gccgaggaca aggaggacga cgaggacaag gacgaggacg aggaggacga ggaggacaag      840

gaggaggacg aggaggagga cgugcccggc caggccaagg acgagcugug a               891


<210>  7583
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7583
augcacggcg acagcgagua caacaucaug uucgggcccg auauuugcgg accuggcacc       60

aagaaagugc augucaucuu uaauuauaag gggaaaaacg uucugauuaa uaaggacauc      120

agauguaaag augacgaguu cacacaccuc uacacgcuga uugugcggcc ggauaacacc      180

uaugaaguga agaucgacaa uucccagguc gaaucuggaa gccuugagga ugacugggau      240

uuucugcccc cuaagaaaau caaggacccc gaugccucca aaccugaaga cugggaugag      300

cgcgcuaaga uugacgaccc cacagauucu aaaccugagg acugggauaa gccggaacau      360

auccccgacc cugaugccaa gaaacccgag gacugggaug aagagaugga cggcgagugg      420

gaaccucccg ugauucaaaa cccggaguac aagggggaau ggaaaccuag acagaucgau      480

aaucccgacu auaagggaac cuggauucac ccugagaucg auaaccccga auacagcccc      540

gacccuucca uuuaugcgua cgacaauuuc ggcguucucg gccuggaucu uuggcaagug      600

aaaucuggga caaucuuuga caacuuccug aucaccaaug augaggcuua cgccgaggaa      660

uuuggaaacg agacaugggg cgucaccaag gccgcugaaa aacagaugaa ggacaagcag      720

gaugaggaac agcggcucaa agaggaggaa gaggacaaga aacgcaagga agaggaagag      780

gccgaggaua aagaagacga ugaggacaag gaugaagacg aggaggauga agaggacaag      840

gaagaggacg aagaggagga ugugccgggg caggcuaaag acgaacugug a               891


<210>  7584
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       calreticulin__Homo_sapiens__BAG65301

<400>  7584
augcacggag auagcgaaua caauauaaug uucgggccag acauaugcgg accaggaaca       60

aaaaaaguac acguaauauu caacuacaaa ggaaaaaacg uacuaauaaa caaagacaua      120

agauguaaag acgacgaauu uacacaccua uacacacuaa uaguaagacc agacaacaca      180

uaugaaguaa aaauagacaa cagucaagua gaaucaggaa gccuagaaga cgacugggac      240

uucuuaccac cgaaaaaaau aaaagaccca gacgcaagca aaccagaaga cugggacgaa      300

agagcgaaaa uagacgaucc aacagacuca aaaccagaag acugggacaa accagaacac      360

auaccagacc cagacgcaaa aaaaccagaa gacugggacg aagaaaugga uggagaaugg      420

gaacccccag uaauccaaaa cccagaauac aaaggagaau ggaaaccaag acaaauagac      480

aacccagacu acaaagggac auggauacac ccagaaauag acaauccaga auauagccca      540

gacccaagua uauacgcaua cgacaacuuc ggaguauuag gauuagaucu auggcaagug      600

aaaaguggaa caauauuuga caacuucuua auaacaaaug augaagcaua cgcagaagaa      660

uucggaaacg aaacaugggg aguaacaaaa gcagcagaaa aacaaaugaa agacaaacaa      720

gacgaagaac aaagauuaaa agaagaagaa gaagauaaaa aaagaaaaga agaagaagaa      780

gcagaagaca aagaagacga cgaagacaaa gacgaagacg aagaagacga agaagacaaa      840

gaagaagacg aagaagaaga cguaccagga caagcaaaag acgaauuaua a               891


<210>  7585
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__P27797

<400>  7585

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  7586
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__AAA36582

<400>  7586
augcugcuau ccgugccgcu gcugcucggc cuccucggcc uggccgucgc cgagcccgcc       60

gucuacuuca aggagcaguu ucuggacgga gacgggugga cuucccgcug gaucgaaucc      120

aaacacaagu cagauuuugg caaauucguu cucaguuccg gcaaguucua cggugacgag      180

gagaaagaua aagguuugca gacaagccag gaugcacgcu uuuaugcucu gucggccagu      240

uucgagccuu ucagcaacaa aggccagacg cugguggugc aguucacggu gaaacaugag      300

cagaacaucg acuguggggg cggcuaugug aagcuguuuc cuaauaguuu ggaccagaca      360

gacaugcacg gagacucaga auacaacauc auguuugguc ccgacaucug uggcccuggc      420

accaagaagg uucaugucau cuucaacuac aagggcaaga acgugcugau caacaaggac      480

auccguugca aggaugauga guuuacacac cuguacacac ugauugugcg gccagacaac      540

accuaugagg ugaagauuga caacagccag guggaguccg gcuccuugga agacgauugg      600

gacuuccugc cacccaagaa gauaaaggau ccugaugcuu caaaaccgga agacugggau      660

gagcgggcca agaucgauga ucccacagac uccaagccug aggacuggga caagcccgag      720

cauaucccug acccugaugc uaagaagccc gaggacuggg augaagagau ggacggagag      780

ugggaacccc cagugauuca gaacccugag uacaagggug aguggaagcc ccggcagauc      840

gacaacccag auuacaaggg cacuuggauc cacccagaaa uugacaaccc cgaguauucu      900

cccgauccca guaucuaugc cuaugauaac uuuggcgugc ugggccugga ccucuggcag      960

gucaagucug gcaccaucuu ugacaacuuc cucaucacca acgaugaggc auacgcugag     1020

gaguuuggca acgagacgug gggcguaaca aaggcagcag agaaacaaau gaaggacaaa     1080

caggacgagg agcagaggcu uaaggaggag gaagaagaca agaaacgcaa agaggaggag     1140

gaggcagagg acaaggagga ugaugaggac aaagaugagg augaggagga ugaggaggac     1200

aaggaggaag augaggagga agaugucccc ggccaggcca aggacgagcu guag           1254


<210>  7587
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7587
augcugcuca gcgugccccu gcugcucggc cugcuggggc ucgccgucgc cgagccggcg       60

guguacuuca aggagcaguu ccuggacggc gacgggugga ccucccgcug gaucgagagc      120

aagcacaagu ccgacuucgg caaguucgug cugagcuccg ggaaguucua cggcgacgag      180

gagaaggaca agggccucca gaccagccag gacgcccggu ucuacgcccu guccgccagc      240

uucgagcccu ucuccaacaa ggggcagacg cuggucgugc aguucaccgu gaagcacgag      300

cagaacaucg acugcggcgg gggcuacguc aagcuguucc ccaacagccu cgaccagacc      360

gacaugcacg gggacuccga guacaacauc auguucggcc ccgacaucug cggcccgggg      420

accaagaagg ugcacgugau cuucaacuac aagggcaaga acguccugau caacaaggac      480

auccgcugca aggacgacga guucacgcac cucuacaccc ugaucgugcg gcccgacaac      540

accuacgagg ugaagaucga caacagccag gucgaguccg ggagccugga ggacgacugg      600

gacuuccucc cgcccaagaa gaucaaggac cccgacgccu ccaagcccga ggacugggac      660

gagcgcgcga agaucgacga ccccaccgac agcaagcccg aggacuggga caagccggag      720

cacauccccg accccgacgc caagaagccc gaggacuggg acgaggagau ggacggcgag      780

ugggagccgc ccgugaucca gaaccccgag uacaagggcg aguggaagcc ccggcagauc      840

gacaacccgg acuacaaggg gacguggauc caccccgaga ucgacaaccc cgaguacucc      900

cccgacccga gcaucuacgc cuacgacaac uucggcgugc uggggcugga ccucuggcag      960

gucaaguccg gcaccaucuu cgacaacuuc cugaucacca acgacgaggc cuacgcggag     1020

gaguucggga acgagaccug gggcgugacg aaggccgccg agaagcagau gaaggacaag     1080

caggacgagg agcagcgccu gaaggaggag gaggaggaca agaagcggaa ggaggaggag     1140

gaggccgagg acaaggagga cgacgaggac aaggacgagg acgaggagga cgaggaggac     1200

aaggaggagg acgaggagga ggacgugccc ggccaggcca aggacgagcu cuga           1254


<210>  7588
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7588
augcuccucu ccgucccccu ccuccucggc cuccucggcc ucgccgucgc cgagcccgcc       60

gucuacuuca aggagcaguu ccucgacggc gacggcugga ccucccgcug gaucgagucc      120

aagcacaagu ccgacuucgg caaguucguc cucuccuccg gcaaguucua cggcgacgag      180

gagaaggaca agggccucca gaccucccag gacgcccgcu ucuacgcccu cuccgccucc      240

uucgagcccu ucuccaacaa gggccagacc cucgucgucc aguucaccgu caagcacgag      300

cagaacaucg acugcggcgg cggcuacguc aagcucuucc ccaacucccu cgaccagacc      360

gacaugcacg gcgacuccga guacaacauc auguucggcc ccgacaucug cggccccggc      420

accaagaagg uccacgucau cuucaacuac aagggcaaga acguccucau caacaaggac      480

auccgcugca aggacgacga guucacccac cucuacaccc ucaucguccg ccccgacaac      540

accuacgagg ucaagaucga caacucccag gucgaguccg gcucccucga ggacgacugg      600

gacuuccucc cccccaagaa gaucaaggac cccgacgccu ccaagcccga ggacugggac      660

gagcgcgcca agaucgacga ccccaccgac uccaagcccg aggacuggga caagcccgag      720

cacauccccg accccgacgc caagaagccc gaggacuggg acgaggagau ggacggcgag      780

ugggagcccc ccgucaucca gaaccccgag uacaagggcg aguggaagcc ccgccagauc      840

gacaaccccg acuacaaggg caccuggauc caccccgaga ucgacaaccc cgaguacucc      900

cccgaccccu ccaucuacgc cuacgacaac uucggcgucc ucggccucga ccucuggcag      960

gucaaguccg gcaccaucuu cgacaacuuc cucaucacca acgacgaggc cuacgccgag     1020

gaguucggca acgagaccug gggcgucacc aaggccgccg agaagcagau gaaggacaag     1080

caggacgagg agcagcgccu caaggaggag gaggaggaca agaagcgcaa ggaggaggag     1140

gaggccgagg acaaggagga cgacgaggac aaggacgagg acgaggagga cgaggaggac     1200

aaggaggagg acgaggagga ggacgucccc ggccaggcca aggacgagcu cuga           1254


<210>  7589
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7589
augcugcuca gcgugccccu ucuguugggc uuacuggggc uagccgucgc ugagccugca       60

guuuacuuca aggaacaguu ucucgacgga gaugguugga ccuccagaug gaucgagucu      120

aaacacaagu cagacuucgg caaauuugug cugaguagcg ggaaguucua uggagaugaa      180

gagaaagaca agggccuuca aacaucccag gaugccaggu uuuacgcgcu gucugcuucg      240

uucgaaccau uuucaaacaa gggucagacu uugguagugc aguucacggu caaacaugag      300

caaaauauug acugcggggg aggcuaugug aagcucuuuc cgaacagccu ggaucagacc      360

gacaugcacg gcgauaguga guacaauaua auguucgggc ccgacaucug uggaccuggu      420

acuaaaaagg uucaugugau uuuuaacuau aaaggcaaga auguccugau caacaaggau      480

auucggugca aagacgauga guucacacac cucuacaccu uaaucgugcg cccagacaau      540

acauaugaag uaaagauaga caacucccag guugaaucug ggagccugga ggaugacugg      600

gauuuucuuc ccccuaaaaa gaucaaagac ccagaugccu ccaagcccga ggacugggau      660

gaacgagcaa aaauugacga uccuaccgac ucaaagccag aggauuggga caagccggaa      720

cauauccccg acccugaugc caaaaagcca gaggacuggg augaagagau ggacggagag      780

ugggaacccc cugugauuca gaauccagag uacaaaggcg aauggaagcc ccgucaaauc      840

gauaacccgg acuacaaagg uacuuggaua cacccugaga uugauaaucc cgaauauagu      900

ccagacccua gcaucuacgc uuaugauaac uucggggucu ugggacugga ccuauggcaa      960

gugaagucug gcacaauuuu cgauaauuuu cucaucacca acgacgaggc auacgccgag     1020

gaguucggca augaaacgug gggagugacu aaggcugccg aaaaacagau gaaggauaaa     1080

caggacgagg aacagagacu gaaggaggag gaagaggaca aaaagaggaa ggaagaggag     1140

gaagcggagg auaaagaaga cgaugaggac aaggaugaag acgaggagga ugaagaggac     1200

aaagaagagg augaagagga ggacgucccc gggcaggcaa aggaugaacu uuga           1254


<210>  7590
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7590
augcugcuga gcgugccccu gcugcugggc cugcugggcc uggccguggc cgagcccgcc       60

guguacuuca aggagcaguu ccuggacggc gacggcugga ccagcagaug gaucgagagc      120

aagcacaaga gcgacuucgg caaguucgug cugagcagcg gcaaguucua cggcgacgag      180

gagaaggaca agggccugca gaccagccag gacgccagau ucuacgcccu gagcgccagc      240

uucgagcccu ucagcaacaa gggccagacc cugguggugc aguucaccgu gaagcacgag      300

cagaacaucg acugcggcgg cggcuacgug aagcuguucc ccaacagccu ggaccagacc      360

gacaugcacg gcgacagcga guacaacauc auguucggcc ccgacaucug cggccccggc      420

accaagaagg ugcacgugau cuucaacuac aagggcaaga acgugcugau caacaaggac      480

aucagaugca aggacgacga guucacccac cuguacaccc ugaucgugag acccgacaac      540

accuacgagg ugaagaucga caacagccag guggagagcg gcagccugga ggacgacugg      600

gacuuccugc cccccaagaa gaucaaggac cccgacgcca gcaagcccga ggacugggac      660

gagagagcca agaucgacga ccccaccgac agcaagcccg aggacuggga caagcccgag      720

cacauccccg accccgacgc caagaagccc gaggacuggg acgaggagau ggacggcgag      780

ugggagcccc ccgugaucca gaaccccgag uacaagggcg aguggaagcc cagacagauc      840

gacaaccccg acuacaaggg caccuggauc caccccgaga ucgacaaccc cgaguacagc      900

cccgacccca gcaucuacgc cuacgacaac uucggcgugc ugggccugga ccuguggcag      960

gugaagagcg gcaccaucuu cgacaacuuc cugaucacca acgacgaggc cuacgccgag     1020

gaguucggca acgagaccug gggcgugacc aaggccgccg agaagcagau gaaggacaag     1080

caggacgagg agcagagacu gaaggaggag gaggaggaca agaagagaaa ggaggaggag     1140

gaggccgagg acaaggagga cgacgaggac aaggacgagg acgaggagga cgaggaggac     1200

aaggaggagg acgaggagga ggacgugccc ggccaggcca aggacgagcu guga           1254


<210>  7591
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7591
augcugcuca gcgugccccu gcuucugggc cuccuggggc uugccgucgc ugagccugcc       60

guuuacuuca aggaacaguu ucuggacgga gauggcugga ccuccagaug gaucgagucu      120

aaacacaaga gcgacuucgg gaaauuugug cucuccucug gaaaguucua uggcgaugaa      180

gagaaagaca aggggcugca aacaagccag gaugcgcggu uuuacgcucu guccgccucu      240

uucgaaccgu uuagcaacaa gggacagacg cucguggucc aguucaccgu gaaacaugag      300

caaaauauug acugcggcgg cggguauguu aagcuguuuc ccaacucccu ugaucagaca      360

gacaugcacg gagauagcga guacaauauc auguucggcc cugacauuug ugggcccgga      420

accaaaaagg ugcaugucau cuuuaacuau aaaggcaaga augugcugau uaacaaggau      480

auccgcugca aagacgauga guucacacac cucuacaccc ugaucguuag accugacaau      540

acauaugaag ugaagauuga caacucucag gucgaauccg ggagccuuga ggaugacugg      600

gauuuucugc ccccuaaaaa gaucaaagac ccggaugccu cuaagcccga ggacugggau      660

gaacgggcua aaauugacga uccuaccgac uccaagcccg aggauuggga caagccugaa      720

cauauccccg acccggaugc caaaaagccu gaggacuggg augaagagau ggacggagag      780

ugggaacccc cugugauuca gaaucccgag uacaaaggcg aauggaagcc ccgccaaauc      840

gauaacccug acuacaaagg cacguggauu cacccggaga ucgauaaucc cgaauauagc      900

ccugaccccu cuaucuacgc uuaugauaac uucggggugc ucggacugga ccuguggcag      960

gucaaguccg gcaccauuuu cgauaauuuu cucaucacaa acgacgaggc cuacgcggag     1020

gaguucggga augaaaccug gggaguuaca aaggccgcug aaaaacagau gaaggauaaa     1080

caggacgagg aacaaagacu gaaggaggag gaagaggaca aaaagcggaa ggaagaggag     1140

gaagccgagg auaaagaaga cgaugaggac aaggaugaag acgaggagga ugaagaggac     1200

aaagaagagg augaagagga ggacgugccu ggccaggcua aggaugaacu uuga           1254


<210>  7592
<211>  1254
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       calreticulin__Homo_sapiens__AAA36582

<400>  7592
augcuauuau caguaccacu ucuauuagga uuauuaggau uagcgguagc agaaccagca       60

guauacuuua aagaacaauu ccuagaugga gacggaugga caagcagaug gauagaaagc      120

aaacauaaaa gcgauuucgg aaaauuugua uuaaguucag guaaauucua uggagacgaa      180

gaaaaagaua aaggguuaca aacaucacaa gaugcaagau ucuaugccuu aucagcaucu      240

uuugaaccau ucaguaauaa aggacaaaca uuaguaguac aauuuacagu aaaacaugaa      300

caaaauauag auuguggugg agguuaugua aaacuauuuc caaauucacu agaccaaaca      360

gacaugcacg gagacagcga auacaauaua auguucggac cagauauaug uggaccagga      420

acaaaaaaag uacauguaau auucaauuau aaaggaaaaa auguacuaau aaacaaagac      480

auaagaugua aagaugacga auucacacac cuguacacgc uaauaguaag accagacaac      540

acauacgaag uaaaaauaga uaacucacaa guugaaagug gaucacuaga agacgauugg      600

gacuuuuuac caccaaaaaa aauaaaagac ccugacgcaa guaaacccga agacugggac      660

gaacgagcaa aaauagacga uccaacagac ucaaaaccgg aagauuggga uaaaccagaa      720

cacauaccag auccagaugc aaaaaagcca gaagacuggg acgaagaaau ggacggagaa      780

ugggaaccac caguaauaca gaacccagaa uauaaaggag aauggaaacc aagacaaaua      840

gauaaccccg acuacaaagg aacauggaua cauccagaaa uagauaaccc agaauauagu      900

ccagauccaa guauauacgc auacgacaac uuuggagucu uaggacuaga ucuauggcaa      960

guaaaaagug gaacaauauu ugacaauuuc uuaauaacaa acgaugaagc guacgcagaa     1020

gaauucggaa acgaaacaug gggaguaacu aaagcagcug aaaaacaaau gaaagauaaa     1080

caagaugaag aacaaagguu gaaagaagaa gaagaggaua aaaaaagaaa agaagaagag     1140

gaagcagaag auaaagaaga ugacgaagac aaagacgaag augaagaaga ugaagaagac     1200

aaagaagaag acgaagaaga agacguacca ggacaagcaa aagaugaauu auaa           1254


<210>  7593
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__Q96L12

<400>  7593

Met Ala Arg Ala Leu Val Gln Leu Trp Ala Ile Cys Met Leu Arg Val 
1               5                   10                  15      


Ala Leu Ala Thr Val Tyr Phe Gln Glu Glu Phe Leu Asp Gly Glu His 
            20                  25                  30          


Trp Arg Asn Arg Trp Leu Gln Ser Thr Asn Asp Ser Arg Phe Gly His 
        35                  40                  45              


Phe Arg Leu Ser Ser Gly Lys Phe Tyr Gly His Lys Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Thr Gln Asn Gly Arg Phe Tyr Ala Ile Ser Ala Arg 
65                  70                  75                  80  


Phe Lys Pro Phe Ser Asn Lys Gly Lys Thr Leu Val Ile Gln Tyr Thr 
                85                  90                  95      


Val Lys His Glu Gln Lys Met Asp Cys Gly Gly Gly Tyr Ile Lys Val 
            100                 105                 110         


Phe Pro Ala Asp Ile Asp Gln Lys Asn Leu Asn Gly Lys Ser Gln Tyr 
        115                 120                 125             


Tyr Ile Met Phe Gly Pro Asp Ile Cys Gly Phe Asp Ile Lys Lys Val 
    130                 135                 140                 


His Val Ile Leu His Phe Lys Asn Lys Tyr His Glu Asn Lys Lys Leu 
145                 150                 155                 160 


Ile Arg Cys Lys Val Asp Gly Phe Thr His Leu Tyr Thr Leu Ile Leu 
                165                 170                 175     


Arg Pro Asp Leu Ser Tyr Asp Val Lys Ile Asp Gly Gln Ser Ile Glu 
            180                 185                 190         


Ser Gly Ser Ile Glu Tyr Asp Trp Asn Leu Thr Ser Leu Lys Lys Glu 
        195                 200                 205             


Thr Ser Pro Ala Glu Ser Lys Asp Trp Glu Gln Thr Lys Asp Asn Lys 
    210                 215                 220                 


Ala Gln Asp Trp Glu Lys His Phe Leu Asp Ala Ser Thr Ser Lys Gln 
225                 230                 235                 240 


Ser Asp Trp Asn Gly Asp Leu Asp Gly Asp Trp Pro Ala Pro Met Leu 
                245                 250                 255     


Gln Lys Pro Pro Tyr Gln Asp Gly Leu Lys Pro Glu Gly Ile His Lys 
            260                 265                 270         


Asp Val Trp Leu His Arg Lys Met Lys Asn Thr Asp Tyr Leu Thr Gln 
        275                 280                 285             


Tyr Asp Leu Ser Glu Phe Glu Asn Ile Gly Ala Ile Gly Leu Glu Leu 
    290                 295                 300                 


Trp Gln Val Arg Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asp 
305                 310                 315                 320 


Asp Glu Glu Tyr Ala Asp Asn Phe Gly Lys Ala Thr Trp Gly Glu Thr 
                325                 330                 335     


Lys Gly Pro Glu Arg Glu Met Asp Ala Ile Gln Ala Lys Glu Glu Met 
            340                 345                 350         


Lys Lys Ala Arg Glu Glu Glu Glu Glu Glu Leu Leu Ser Gly Lys Ile 
        355                 360                 365             


Asn Arg His Glu His Tyr Phe Asn Gln Phe His Arg Arg Asn Glu Leu 
    370                 375                 380                 






<210>  7594
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  calreticulin__Homo_sapiens__BAB71655

<400>  7594
auggcccggg cuuuggucca gcucugggcc auaugcaugc ugcgaguggc gcuggcuacc       60

gucuauuucc aagaggaauu ucuagacgga gagcauugga gaaaccgaug guugcagucc      120

accaaugacu cccgauuugg gcauuuuaga cuuucgucgg gcaaguuuua uggucauaaa      180

gagaaagaua aaggucugca aaccacucag aauggccgau ucuaugccau cucugcacgc      240

uucaaaccgu ucagcaauaa agggaaaacu cugguuauuc aguacacagu aaaacaugag      300

cagaagaugg acuguggagg gggcuacauu aaggucuuuc cugcagacau ugaccagaag      360

aaccugaaug gaaaaucgca auacuauauu auguuuggac ccgauauuug uggauuugau      420

aucaagaaag uucauguuau uuuacauuuc aagaauaagu aucacgaaaa caagaaacug      480

aucaggugua agguugaugg cuucacacac cuguacacuc uaauuuuaag accagaucuu      540

ucuuaugaug ugaaaauuga uggucaguca auugaauccg gcagcauaga guacgacugg      600

aacuuaacau cacucaagaa ggaaacgucc ccggcagaau cgaaggauug ggaacagacu      660

aaagacaaca aagcccagga cugggagaag cauuuucugg acgccagcac cagcaagcag      720

agcgacugga acggugaccu ggauggggac uggccagcgc cgaugcucca gaagcccccg      780

uaccaggaug gccugaaacc agaagguauu cauaaagacg ucuggcucca ccguaagaug      840

aagaauaccg acuauuugac gcaguaugac cucucagaau uugagaacau uggugccauu      900

ggccuggagc uuuggcaggu gagaucugga accauuuuug auaacuuucu gaucacagau      960

gaugaagagu augcagauaa uuuuggcaag gccaccuggg gcgaaaccaa ggguccagaa     1020

agggagaugg augccauaca ggccaaggag gaaaugaaga aggcccgcga ggaagaggag     1080

gaagagcugc ugucgggaaa aauuaacagg cacgaacauu acuucaauca auuucacaga     1140

aggaaugaac uuuag                                                      1155


<210>  7595
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7595
auggcccgcg cccuggugca gcucugggcg aucugcaugc ugcggguggc ccuggccacc       60

guguacuucc aggaggaguu ccucgacggc gagcacuggc gcaaccggug gcugcagagc      120

accaacgacu cccgcuucgg gcacuuccgg cugagcuccg gcaaguucua cgggcacaag      180

gagaaggaca agggccucca gacgacccag aacgggcgcu ucuacgccau cagcgcccgg      240

uucaagcccu ucuccaacaa gggcaagacc cuggugaucc aguacaccgu caagcacgag      300

cagaagaugg acugcggcgg gggcuacauc aagguguucc cggcggacau cgaccagaag      360

aaccugaacg gcaagagcca guacuacauc auguucgggc ccgacaucug cggguucgac      420

aucaagaagg ugcacgucau ccuccacuuc aagaacaagu accacgagaa caagaagcug      480

auccgcugca agguggacgg cuucacgcac cuguacaccc ucauccugcg gcccgaccug      540

uccuacgacg ugaagaucga cggccagagc aucgaguccg ggagcaucga guacgacugg      600

aaccucaccu cccugaagaa ggagaccagc cccgccgagu ccaaggacug ggagcagacg      660

aaggacaaca aggcccagga cugggagaag cacuuccugg acgccagcac cuccaagcag      720

agcgacugga acggcgaccu cgacggggac uggccggcgc ccaugcugca gaagccgccc      780

uaccaggacg gccugaagcc cgagggcauc cacaaggacg ucuggcucca ccgcaagaug      840

aagaacaccg acuaccugac ccaguacgac cuguccgagu ucgagaacau cggggccauc      900

ggccucgagc uguggcaggu ccggagcggg acgaucuucg acaacuuccu gaucaccgac      960

gacgaggagu acgccgacaa cuucggcaag gccaccuggg gcgagaccaa ggggcccgag     1020

cgcgagaugg acgccaucca ggcgaaggag gagaugaaga aggcccggga ggaggaggag     1080

gaggagcucc uguccggcaa gaucaaccgc cacgagcacu acuucaacca guuccaccgg     1140

cgcaacgagc uguga                                                      1155


<210>  7596
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7596
auggcccgcg cccucgucca gcucugggcc aucugcaugc uccgcgucgc ccucgccacc       60

gucuacuucc aggaggaguu ccucgacggc gagcacuggc gcaaccgcug gcuccagucc      120

accaacgacu cccgcuucgg ccacuuccgc cucuccuccg gcaaguucua cggccacaag      180

gagaaggaca agggccucca gaccacccag aacggccgcu ucuacgccau cuccgcccgc      240

uucaagcccu ucuccaacaa gggcaagacc cucgucaucc aguacaccgu caagcacgag      300

cagaagaugg acugcggcgg cggcuacauc aaggucuucc ccgccgacau cgaccagaag      360

aaccucaacg gcaaguccca guacuacauc auguucggcc ccgacaucug cggcuucgac      420

aucaagaagg uccacgucau ccuccacuuc aagaacaagu accacgagaa caagaagcuc      480

auccgcugca aggucgacgg cuucacccac cucuacaccc ucauccuccg ccccgaccuc      540

uccuacgacg ucaagaucga cggccagucc aucgaguccg gcuccaucga guacgacugg      600

aaccucaccu cccucaagaa ggagaccucc cccgccgagu ccaaggacug ggagcagacc      660

aaggacaaca aggcccagga cugggagaag cacuuccucg acgccuccac cuccaagcag      720

uccgacugga acggcgaccu cgacggcgac uggcccgccc ccaugcucca gaagcccccc      780

uaccaggacg gccucaagcc cgagggcauc cacaaggacg ucuggcucca ccgcaagaug      840

aagaacaccg acuaccucac ccaguacgac cucuccgagu ucgagaacau cggcgccauc      900

ggccucgagc ucuggcaggu ccgcuccggc accaucuucg acaacuuccu caucaccgac      960

gacgaggagu acgccgacaa cuucggcaag gccaccuggg gcgagaccaa gggccccgag     1020

cgcgagaugg acgccaucca ggccaaggag gagaugaaga aggcccgcga ggaggaggag     1080

gaggagcucc ucuccggcaa gaucaaccgc cacgagcacu acuucaacca guuccaccgc     1140

cgcaacgagc ucuga                                                      1155


<210>  7597
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7597
auggccagag cucuggugca gcucugggca aucugcaugc uuagggucgc ccuggcgacc       60

guuuacuucc aagaggaauu uuuggacggc gagcacuggc ggaaccgcug guuacagagc      120

acaaaugauu cccgauucgg gcauuuucgu cugucuucag gaaaguucua uggucacaaa      180

gaaaaggaca aaggccuaca gacuacgcag aacgggagau uuuacgcuau uagugccagg      240

uucaagcccu uuagcaauaa aggaaagacc cucgugauac aauauacagu aaagcaugag      300

cagaaaaugg auuguggcgg uggguacauc aagguguucc cugcagacau ugaucagaaa      360

aaccugaaug gaaaguccca guauuacauc auguuuggcc cagacauuug cggcuucgau      420

aucaaaaagg uccacgugau acuucauuuu aagaacaaau aucacgaaaa uaagaaacug      480

auccggugua agguugacgg guucacucac uuguacaccc ucauucugcg cccggaucug      540

ucuuacgacg ugaaaaucga uggacaaucg auugagucag guagcaucga guaugacugg      600

aaccucacaa guuuaaagaa agaaaccucc cccgccgagu cuaaggauug ggaacagacu      660

aaggacaaua aagcucagga cugggagaag cauuuucugg augcaagcac auccaaacag      720

ucagacugga acggcgaucu ugacggggau uggccugccc caauguugca aaagcccccu      780

uaccaggacg gacugaaacc agagggcaua cacaaggaug ucuggcuaca uagaaagaug      840

aaaaauaccg acuaucucac gcaguacgau cugagugaau uugagaacau uggugcuauc      900

gggcuugaac uguggcaagu gaggagcgga acuauuuucg acaauuucuu gaucaccgau      960

gacgaggaau augccgacaa cuucggcaag gcgacauggg gcgagacuaa agggcccgag     1020

cgggaaaugg augcaaucca ggccaaggag gaaaugaaaa aggcucgcga ggaagaggag     1080

gaggaacucc ugucuggaaa gauuaaucga cacgaacacu acuuuaacca guuccauaga     1140

aggaacgagu uauga                                                      1155


<210>  7598
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7598
auggccagag cccuggugca gcugugggcc aucugcaugc ugagaguggc ccuggccacc       60

guguacuucc aggaggaguu ccuggacggc gagcacugga gaaacagaug gcugcagagc      120

accaacgaca gcagauucgg ccacuucaga cugagcagcg gcaaguucua cggccacaag      180

gagaaggaca agggccugca gaccacccag aacggcagau ucuacgccau cagcgccaga      240

uucaagcccu ucagcaacaa gggcaagacc cuggugaucc aguacaccgu gaagcacgag      300

cagaagaugg acugcggcgg cggcuacauc aagguguucc ccgccgacau cgaccagaag      360

aaccugaacg gcaagagcca guacuacauc auguucggcc ccgacaucug cggcuucgac      420

aucaagaagg ugcacgugau ccugcacuuc aagaacaagu accacgagaa caagaagcug      480

aucagaugca agguggacgg cuucacccac cuguacaccc ugauccugag acccgaccug      540

agcuacgacg ugaagaucga cggccagagc aucgagagcg gcagcaucga guacgacugg      600

aaccugacca gccugaagaa ggagaccagc cccgccgaga gcaaggacug ggagcagacc      660

aaggacaaca aggcccagga cugggagaag cacuuccugg acgccagcac cagcaagcag      720

agcgacugga acggcgaccu ggacggcgac uggcccgccc ccaugcugca gaagcccccc      780

uaccaggacg gccugaagcc cgagggcauc cacaaggacg uguggcugca cagaaagaug      840

aagaacaccg acuaccugac ccaguacgac cugagcgagu ucgagaacau cggcgccauc      900

ggccuggagc uguggcaggu gagaagcggc accaucuucg acaacuuccu gaucaccgac      960

gacgaggagu acgccgacaa cuucggcaag gccaccuggg gcgagaccaa gggccccgag     1020

agagagaugg acgccaucca ggccaaggag gagaugaaga aggccagaga ggaggaggag     1080

gaggagcugc ugagcggcaa gaucaacaga cacgagcacu acuucaacca guuccacaga     1140

agaaacgagc uguga                                                      1155


<210>  7599
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7599
auggccagag cucuggugca gcucugggcc aucugcaugc ugcgggucgc gcuugcuacc       60

guuuacuucc aagaggaauu ucuggacggc gagcacuggc gcaacagaug gcuccagagc      120

acaaaugauu cccgguucgg gcauuuucgc cugucuagcg gaaaguucua uggccacaaa      180

gaaaaggaca aagggcuuca gacgacccag aacggaagau uuuacgccau uuccgcccgg      240

uucaagcccu uuucuaauaa aggcaagaca cuggugaucc aauauaccgu gaagcaugag      300

cagaaaaugg auuguggggg aggcuacauu aaggucuucc cugcugacau cgaucagaaa      360

aaccucaaug gcaagagcca guauuacauu auguuugggc cggacaucug cggauucgau      420

aucaaaaagg ugcacguuau ucugcauuuu aagaacaaau aucacgaaaa uaagaaacug      480

auccgcugua agguggacgg cuucacacac cucuacaccc ugauucuuag acccgaucug      540

uccuacgacg ucaaaaucga ugggcaaucu auugagagcg gauccaucga guaugacugg      600

aaccucacaa gccugaagaa agaaaccucu ccugccgagu ccaaggauug ggaacagacg      660

aaggacaaua aagcucagga cugggagaag cauuuucuug augccagcac cucuaaacag      720

uccgacugga acggcgaucu ggacggggau uggcccgcgc cuaugcucca aaagcccccu      780

uaccaggacg gacugaaacc ggagggcauu cacaaggaug uguggcugca ucggaagaug      840

aaaaauacag acuaucucac ccaguacgau cugagcgagu ucgagaacau cggcgccauc      900

gggcuugaac uguggcaagu ucgcucugga acaauuuucg acaauuuucu caucaccgau      960

gacgaggaau augcugacaa cuucggcaag gccacguggg gagagacaaa agggcccgag     1020

agagaaaugg augcuauuca ggccaaggag gaaaugaaaa aggcgcggga ggaagaggag     1080

gaagaacugc uuuccggcaa gaucaaucgc cacgaacacu acuuuaacca guuccauaga     1140

cggaacgagc uguga                                                      1155


<210>  7600
<211>  1155
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       calreticulin__Homo_sapiens__BAB71655

<400>  7600
auggccagag cacuagucca auuaugggca auaugcaugu uacgaguugc acuagcuaca       60

guauacuuuc aagaagaauu ccuagacgga gaacacuggc gaaacagaug gcuacaauca      120

acaaaugauu caagauucgg acacuucaga cuaaguagcg gaaaauucua uggacacaaa      180

gaaaaagaca aaggccuaca aacaacacaa aauggaagau uuuaugcaau aucagcaaga      240

uucaaaccau ucucaaauaa aggaaaaaca cuaguaauac aauacacagu aaaacaugaa      300

cagaaaaugg acugcggagg aggauacauc aaggucuucc cagcagacau agaccaaaaa      360

aacuuaaacg gcaaaucaca auacuacaua auguuuggac cagacaucug uggauucgac      420

auaaaaaaag uacauguaau acuacacuuc aaaaauaaau accacgaaaa uaaaaaacua      480

auaagaugca aaguagacgg auuuacacac uuauacacac uaauauuacg accagaccua      540

ucauacgacg uaaaaaucga cggacaauca auagaaucag gaucaauaga auacgacugg      600

aaccuaacau cauuaaaaaa agaaacauca ccagcagaau caaaagacug ggaacaaaca      660

aaagacaaca aagcacaaga cugggaaaaa cacuuccuag acgcaagcac aagcaaacaa      720

ucagacugga acggagaucu agacggagac uggccagcac caauguuaca aaaaccaccu      780

uaucaagacg gacuaaaacc agaaggaaua cauaaagacg uaugguuaca caggaaaaug      840

aaaaauacag acuaccuaac acaauacgac uuaucagaau ucgaaaacau aggagcaaua      900

ggacuagaac uauggcaagu aagaagugga acaauauucg acaauuuccu aauaacagac      960

gacgaagaau acgcagacaa uuucgguaaa gcaacauggg gcgaaacaaa aggaccagaa     1020

agagaaaugg acgcaauaca agcaaaagaa gaaaugaaaa aagcaagaga agaagaagaa     1080

gaagaacuac uuaguggcaa aauaaacaga cacgaacacu acuucaacca auuucacaga     1140

agaaaugaau uauaa                                                      1155


<210>  7601
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GRP170_(ORP150)__Homo_sapiens__Q9Y4L1

<400>  7601

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  7602
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7602
auggcagaca aaguuaggag gcagaggccg aggaggcgag ucuguugggc cuugguggcu       60

gugcucuugg cagaccuguu ggcacugagu gauacacugg cagugauguc uguggaccug      120

ggcagugagu ccaugaaggu ggccauuguc aaaccuggag ugcccaugga aauugucuug      180

aauaaggaau cucggaggaa aacaccggug aucgugaccc ugaaagaaaa ugaaagauuc      240

uuuggagaca gugcagcaag cauggcgauu aagaauccaa aggcuacgcu acguuacuuc      300

cagcaccucc uggggaagca ggcagauaac ccccauguag cucuuuacca ggcccgcuuc      360

ccggagcacg agcugacuuu cgacccacag aggcagacug ugcacuuuca gaucagcucg      420

cagcugcagu ucucaccuga ggaaguguug ggcaugguuc ucaauuauuc ucguucucua      480

gcugaagauu uugcagagca gcccaucaag gaugcaguga ucaccgugcc agucuucuuc      540

aaccaggccg agcgccgagc ugugcugcag gcugcucgua uggcuggccu caaagugcug      600

cagcucauca augacaacac cgccacugcc cucagcuaug gugucuuccg ccggaaagau      660

auuaacacca cugcccagaa uaucauguuc uaugacaugg gcucaggcag caccguaugc      720

accauuguga ccuaccagau ggugaagacu aaggaagcug ggaugcagcc acagcugcag      780

auccggggag uaggauuuga ccguacccug gggggccugg agauggagcu ccggcuucga      840

gaacgccugg cugggcuuuu caaugagcag cgcaaggguc agagagcaaa ggaugugcgg      900

gagaacccgc gugccauggc caagcugcug cgugaggcua aucggcucaa aaccguccuc      960

agugccaacg cugaccacau ggcacagauu gaaggccuga uggaugaugu ggacuucaag     1020

gcaaaaguga cucgugugga auuugaggag uugugugcag acuuguuuga gcgggugccu     1080

gggccuguac agcaggcccu ccagagugcc gaaaugaguc uggaugagau ugagcaggug     1140

auccuggugg guggggccac ucgggucccc agaguucagg aggugcugcu gaaggccgug     1200

ggcaaggagg agcuggggaa gaacaucaau gcagaugaag cagccgccau gggggcagug     1260

uaccaggcag cugcgcucag caaagccuuu aaagugaagc cauuugucgu ccgagaugca     1320

guggucuacc ccauccuggu ggaguucacg agggaggugg aggaggagcc ugggauucac     1380

agccugaagc acaauaaacg gguacucuuc ucucggaugg ggcccuaccc ucaacgcaaa     1440

gucaucaccu uuaaccgcua cagccaugau uucaacuucc acaucaacua cggcgaccug     1500

ggcuuccugg ggccugaaga ucuucgggua uuuggcuccc agaaucugac cacagugaag     1560

cuaaaagggg ugggugacag cuucaagaag uauccugacu acgaguccaa gggcaucaag     1620

gcucacuuca accuggauga gaguggcgug cucagucuag acagggugga gucuguauuu     1680

gagacacugg uagaggacag cgcagaagag gaaucuacuc ucaccaaacu uggcaacacc     1740

auuuccagcc uguuuggagg cgguaccaca ccagaugcca aggagaaugg uacugauacu     1800

guccaggagg aagaggagag cccugcagag gggagcaagg acgagccugg ggagcaggug     1860

gagcucaagg aggaagcuga ggccccagug gaggauggcu cucagccccc acccccugaa     1920

ccuaagggag augcaacccc ugagggagaa aaggccacag aaaaagaaaa uggggacaag     1980

ucugaggccc agaaaccaag ugagaaggca gaggcagggc cugagggcgu cgcuccagcc     2040

ccagagggag agaagaagca gaagcccgcc aggaagcggc gaaugguaga ggagaucggg     2100

guggagcugg uuguucugga ccugccugac uugccagagg auaagcuggc ucagucggug     2160

cagaaacuuc aggacuugac acuccgagac cuggagaagc aggaacggga aaaagcugcc     2220

aacagcuugg aagcguucau auuugagacc caggacaagc uguaccagcc cgaguaccag     2280

gaagugucca cagaggagca gcgugaggag aucucuggga agcucagcgc cgcauccacc     2340

uggcuggagg augagggugu uggagccacc acagugaugu ugaaggagaa gcuggcugag     2400

cugaggaagc ugugccaagg gcuguuuuuu cggguagagg agcgcaagaa guggcccgaa     2460

cggcugucug cccucgauaa ucuccucaac cauuccagca uguuccucaa gggggcccgg     2520

cucaucccag agauggacca gaucuucacu gagguggaga ugacaacguu agagaaaguc     2580

aucaaugaga ccugggccug gaagaaugca acucuggccg agcaggcuaa gcugcccgcc     2640

acagagaagc cuguguugcu cucaaaagac auugaagcua agaugauggc ccuggaccga     2700

gaggugcagu aucugcucaa uaaggccaag uuuaccaagc cccggccccg gccuaaggac     2760

aagaauggga cccgggcaga gccaccccuc aaugccagug ccagugacca gggggagaag     2820

gucaucccuc cagcaggcca gacugaagau gcagagccca uuucagaacc ugagaaagua     2880

gagacuggau ccgagccagg agacacugag ccuuuggagu uaggaggucc uggagcagaa     2940

ccugaacaga aagaacaauc gacaggacag aagcggccuu ugaagaacga cgaacuauaa     3000


<210>  7603
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7603
auggccgaca aggugcgccg gcagcgcccc cggcgccggg ucugcugggc ccugguggcg       60

gugcuccugg ccgaccugcu cgcccugagc gacacccugg ccgucauguc cguggaccuc      120

ggcagcgagu ccaugaaggu ggccaucguc aagccggggg ugcccaugga gaucgugcug      180

aacaaggaga gccgccggaa gacccccguc aucgugacgc ugaaggagaa cgagcgcuuc      240

uucggcgacu ccgcggccag cauggccauc aagaacccca aggccacccu ccgguacuuc      300

cagcaccucc uggggaagca ggcggacaac ccgcacgugg cccuguacca ggcccgcuuc      360

cccgagcacg agcugaccuu cgacccccag cggcagaccg uccacuucca gaucuccagc      420

cagcugcagu ucucccccga ggaggugcuc ggcauggugc ugaacuacag ccgcucccug      480

gccgaggacu ucgccgagca gccgaucaag gacgcgguca ucacggugcc cguguucuuc      540

aaccaggccg agcggcgcgc cguccuccag gccgcccgga uggcggggcu gaaggugcug      600

cagcucauca acgacaacac cgccaccgcc cugagcuacg gcguguuccg ccggaaggac      660

aucaacacca cggcccagaa caucauguuc uacgacaugg gcuccgggag caccgucugc      720

accaucguga ccuaccagau ggugaagacg aaggaggccg gcaugcagcc ccagcugcag      780

auccgcgggg ucggcuucga ccggacccuc gggggccugg agauggagcu gcgccuccgg      840

gagcgccugg cgggccuguu caacgagcag cgcaaggggc agcgggccaa ggacgugcgc      900

gagaaccccc gggccauggc caagcuccug cgcgaggcca accggcugaa gaccguccuc      960

uccgcgaacg ccgaccacau ggcccagauc gagggccuga uggacgacgu ggacuucaag     1020

gccaagguga cccgcgucga guucgaggag cugugcgcgg accucuucga gcgggugccg     1080

gggcccgugc agcaggcccu gcagagcgcc gagauguccc uggacgagau cgagcagguc     1140

auccucgugg gcggcgccac gcgcgugccc cggguccagg aggugcugcu gaaggccgug     1200

gggaaggagg agcucggcaa gaacaucaac gcggacgagg ccgccgccau gggggccguc     1260

uaccaggcgg ccgcccugag caaggccuuc aaggugaagc ccuucguggu ccgcgacgcc     1320

gugguguacc cgauccuggu cgaguucacc cgggaggugg aggaggagcc cggcauccac     1380

ucccucaagc acaacaagcg cgugcuguuc agccggaugg ggcccuaccc ccagcgcaag     1440

gucaucaccu ucaaccggua cagccacgac uucaacuucc acaucaacua cggcgaccug     1500

ggcuuccucg ggccggagga ccugcgcgug uucggcuccc agaaccugac cacggugaag     1560

cugaaggggg ucggcgacag cuucaagaag uaccccgacu acgaguccaa ggggaucaag     1620

gcgcacuuca accucgacga gagcggcgug cugucccugg accgggugga gagcgucuuc     1680

gagacccucg uggaggacuc cgccgaggag gagagcaccc ugaccaagcu gggcaacacg     1740

aucuccagcc ucuucggggg cgggaccacc cccgacgcca aggagaacgg caccgacacg     1800

gugcaggagg aggaggaguc ccccgccgag gggagcaagg acgagccggg cgagcagguc     1860

gagcugaagg aggaggcgga ggcccccgug gaggacggcu cccagccgcc gccgcccgag     1920

cccaaggggg acgccacccc cgagggcgag aaggccaccg agaaggagaa cggggacaag     1980

agcgaggccc agaagcccuc cgagaaggcg gaggccggcc ccgagggcgu ggcccccgcc     2040

cccgaggggg agaagaagca gaagcccgcc cgcaagcggc gcauggucga ggagaucggc     2100

guggagcugg ugguccucga ccugcccgac cugcccgagg acaagcucgc gcagagcgug     2160

cagaagcugc aggaccugac ccuccgcgac cuggagaagc aggagcggga gaaggccgcc     2220

aacucccugg aggccuucau cuucgagacg caggacaagc ucuaccagcc ggaguaccag     2280

gaggugagca ccgaggagca gcgcgaggag aucuccggga agcugagcgc cgcgagcacc     2340

uggcuggagg acgagggcgu cggggccacc acggugaugc ucaaggagaa gcuggccgag     2400

cugcggaagc ucugccaggg ccuguucuuc cgcguggagg agcggaagaa guggcccgag     2460

cgccuguccg cccucgacaa ccugcugaac cacagcucca uguuccucaa gggcgcgcgg     2520

cugauccccg agauggacca gaucuucacc gaggucgaga ugaccacccu ggagaaggug     2580

aucaacgaga ccugggccug gaagaacgcc acgcucgccg agcaggccaa gcugcccgcg     2640

accgagaagc cggugcugcu cagcaaggac aucgaggcca agaugauggc ccuggaccgc     2700

gagguccagu accugcucaa caaggccaag uucaccaagc cccggccccg ccccaaggac     2760

aagaacggga cccgggccga gccgccccug aacgcguccg ccagcgacca gggcgagaag     2820

gugaucccgc ccgccgggca gacggaggac gccgagccca ucuccgagcc cgagaaggug     2880

gagaccggca gcgagcccgg ggacaccgag ccccuggagc ucggcggccc gggggccgag     2940

cccgagcaga aggagcaguc caccggccag aagcgccccc ugaagaacga cgagcuguga     3000


<210>  7604
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7604
auggccgaca agguccgccg ccagcgcccc cgccgccgcg ucugcugggc ccucgucgcc       60

guccuccucg ccgaccuccu cgcccucucc gacacccucg ccgucauguc cgucgaccuc      120

ggcuccgagu ccaugaaggu cgccaucguc aagcccggcg uccccaugga gaucguccuc      180

aacaaggagu cccgccgcaa gacccccguc aucgucaccc ucaaggagaa cgagcgcuuc      240

uucggcgacu ccgccgccuc cauggccauc aagaacccca aggccacccu ccgcuacuuc      300

cagcaccucc ucggcaagca ggccgacaac ccccacgucg cccucuacca ggcccgcuuc      360

cccgagcacg agcucaccuu cgacccccag cgccagaccg uccacuucca gaucuccucc      420

cagcuccagu ucucccccga ggagguccuc ggcauggucc ucaacuacuc ccgcucccuc      480

gccgaggacu ucgccgagca gcccaucaag gacgccguca ucaccguccc cgucuucuuc      540

aaccaggccg agcgccgcgc cguccuccag gccgcccgca uggccggccu caagguccuc      600

cagcucauca acgacaacac cgccaccgcc cucuccuacg gcgucuuccg ccgcaaggac      660

aucaacacca ccgcccagaa caucauguuc uacgacaugg gcuccggcuc caccgucugc      720

accaucguca ccuaccagau ggucaagacc aaggaggccg gcaugcagcc ccagcuccag      780

auccgcggcg ucggcuucga ccgcacccuc ggcggccucg agauggagcu ccgccuccgc      840

gagcgccucg ccggccucuu caacgagcag cgcaagggcc agcgcgccaa ggacguccgc      900

gagaaccccc gcgccauggc caagcuccuc cgcgaggcca accgccucaa gaccguccuc      960

uccgccaacg ccgaccacau ggcccagauc gagggccuca uggacgacgu cgacuucaag     1020

gccaagguca cccgcgucga guucgaggag cucugcgccg accucuucga gcgcgucccc     1080

ggccccgucc agcaggcccu ccaguccgcc gagauguccc ucgacgagau cgagcagguc     1140

auccucgucg gcggcgccac ccgcgucccc cgcguccagg agguccuccu caaggccguc     1200

ggcaaggagg agcucggcaa gaacaucaac gccgacgagg ccgccgccau gggcgccguc     1260

uaccaggccg ccgcccucuc caaggccuuc aaggucaagc ccuucgucgu ccgcgacgcc     1320

gucgucuacc ccauccucgu cgaguucacc cgcgaggucg aggaggagcc cggcauccac     1380

ucccucaagc acaacaagcg cguccucuuc ucccgcaugg gccccuaccc ccagcgcaag     1440

gucaucaccu ucaaccgcua cucccacgac uucaacuucc acaucaacua cggcgaccuc     1500

ggcuuccucg gccccgagga ccuccgcguc uucggcuccc agaaccucac caccgucaag     1560

cucaagggcg ucggcgacuc cuucaagaag uaccccgacu acgaguccaa gggcaucaag     1620

gcccacuuca accucgacga guccggcguc cucucccucg accgcgucga guccgucuuc     1680

gagacccucg ucgaggacuc cgccgaggag gaguccaccc ucaccaagcu cggcaacacc     1740

aucuccuccc ucuucggcgg cggcaccacc cccgacgcca aggagaacgg caccgacacc     1800

guccaggagg aggaggaguc ccccgccgag ggcuccaagg acgagcccgg cgagcagguc     1860

gagcucaagg aggaggccga ggcccccguc gaggacggcu cccagccccc cccccccgag     1920

cccaagggcg acgccacccc cgagggcgag aaggccaccg agaaggagaa cggcgacaag     1980

uccgaggccc agaagcccuc cgagaaggcc gaggccggcc ccgagggcgu cgcccccgcc     2040

cccgagggcg agaagaagca gaagcccgcc cgcaagcgcc gcauggucga ggagaucggc     2100

gucgagcucg ucguccucga ccuccccgac cuccccgagg acaagcucgc ccaguccguc     2160

cagaagcucc aggaccucac ccuccgcgac cucgagaagc aggagcgcga gaaggccgcc     2220

aacucccucg aggccuucau cuucgagacc caggacaagc ucuaccagcc cgaguaccag     2280

gaggucucca ccgaggagca gcgcgaggag aucuccggca agcucuccgc cgccuccacc     2340

uggcucgagg acgagggcgu cggcgccacc accgucaugc ucaaggagaa gcucgccgag     2400

cuccgcaagc ucugccaggg ccucuucuuc cgcgucgagg agcgcaagaa guggcccgag     2460

cgccucuccg cccucgacaa ccuccucaac cacuccucca uguuccucaa gggcgcccgc     2520

cucauccccg agauggacca gaucuucacc gaggucgaga ugaccacccu cgagaagguc     2580

aucaacgaga ccugggccug gaagaacgcc acccucgccg agcaggccaa gcuccccgcc     2640

accgagaagc ccguccuccu cuccaaggac aucgaggcca agaugauggc ccucgaccgc     2700

gagguccagu accuccucaa caaggccaag uucaccaagc cccgcccccg ccccaaggac     2760

aagaacggca cccgcgccga gcccccccuc aacgccuccg ccuccgacca gggcgagaag     2820

gucauccccc ccgccggcca gaccgaggac gccgagccca ucuccgagcc cgagaagguc     2880

gagaccggcu ccgagcccgg cgacaccgag ccccucgagc ucggcggccc cggcgccgag     2940

cccgagcaga aggagcaguc caccggccag aagcgccccc ucaagaacga cgagcucuga     3000


<210>  7605
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7605
auggccgaca aggugagaag gcagcggccc cgccgacgug ucugcugggc ucugguugca       60

gugcuccuug ccgaucuguu ggcguuaagc gacacccugg cuguaauguc cguggaucua      120

ggcucugagu caaugaaagu cgccaucgug aagccugggg uuccaaugga aauugugcuc      180

aacaaagaga guagaaggaa gacaccgguc auagugacuc ugaaagaaaa ugagcgguuc      240

uuuggagaca gcgcagccuc cauggcuauc aagaacccca aggcaacgcu ucgcuacuuc      300

caacaccugu uggguaaaca ggccgauaau ccucauguag cucucuauca ggccagauuu      360

ccagaacacg agcugaccuu cgacccccag aggcaaacag uucauuuuca gauuucuucg      420

cagcugcagu ucucaccuga ggaagugcuc ggcauggucu uaaacuacag ccggagucug      480

gcggaggauu uugcagaaca accaaucaag gacgccguga uuacugugcc cgucuucuuu      540

aaucaggcug agcgccgagc cguucuucag gcagcuagaa uggccggguu gaaagugcug      600

cagcuaauca acgauaauac cgcgacagcc cucuccuaug gaguauucag gcggaaggac      660

auaaacacca cugcacaaaa uaucauguuu uacgauaugg gcucugguag cacagugugu      720

accauuguca cguaucagau ggugaaaacu aaggaggcug ggaugcagcc ucaacugcag      780

auccguggag uuggcuucga ccgcacccuu ggcgggcugg aaauggaguu gagacucagg      840

gaacggcugg ccggauuauu uaacgagcag cgaaaggguc agcgcgcuaa agaugugaga      900

gaaaauccaa gggccauggc aaagcugcuc cgggaggcca accgccuuaa aacaguccug      960

uccgcuaaug cggaccacau ggcacaaauu gagggcuuga uggacgaugu ggacuucaag     1020

gccaaaguaa cuagaguuga guucgaggaa cuaugcgcug aucuguuuga gagggugccg     1080

gggcccgucc agcaggcccu ccagucagca gaaaugaguc uggacgagau cgagcaagug     1140

auacuugucg gaggcgccac ccgugugccu cggguucagg aagugcuguu gaaggcugua     1200

gguaaagagg aacucgggaa gaacauuaau gccgaugagg cagcggcuau gggagccguc     1260

uaccaggcag ccgcucugag caaggccuuc aaagugaagc cauuuguugu gcgagacgca     1320

gucguguauc ccaucuuagu agaguucaca agagaggugg aggaagaacc uggcauucau     1380

ucucugaaac acaacaagag gguucuauuu ucccgcaugg gcccauaccc ccagcggaaa     1440

gucaucaccu ucaacagaua cucacacgau uuuaauuucc auaucaacua uggggaccuc     1500

ggauuucugg guccggaaga ucuuagggug uucggcagcc aaaauuugac gacugugaag     1560

cugaaggggg ucggagacag uuuuaaaaag uacccugauu augagucuaa aggcauuaag     1620

gcucacuuca accucgacga guccgguguu cugagccuug accgcgugga aucgguguuu     1680

gagacacugg uagaagauuc ugccgaggaa gaguccaccu ugacuaaacu cgggaauaca     1740

auaucaaguc uguucggcgg aggcaccacg cccgacgcga aggagaacgg gaccgauaca     1800

guccaggaag aggaagagag cccagccgaa ggauccaagg acgagccugg ugaacaggug     1860

gaauuaaaag aggaagcuga ggcacccguu gaagauggcu cucagccacc cccuccagag     1920

ccgaaggggg acgccacucc cgagggagaa aaagcuaccg agaaggaaaa uggcgauaaa     1980

agcgaggccc aaaagccuuc agagaaggca gaagcggguc cagagggggu ggcccccgcu     2040

ccugaaggcg agaaaaagca gaaaccagcc cgaaagcggc guauggucga agagaucgga     2100

guggagcugg uugugcuaga ccuccccgau cugccggaag acaaacuugc acagagugua     2160

caaaaguugc aggaucugac acucagagac cuggagaaac aggaaaggga gaaggcugcc     2220

aacuccuuag aagcauucau uuuugagacu caggauaagc uguaccaacc ugaguaucag     2280

gaagucagca ccgaggaaca gcgcgaggaa aucucuggca aacuuucagc cgcuaguaca     2340

ugguuggagg acgagggggu gggagcgacc acugugaugc ucaaggaaaa acuggccgag     2400

cuacggaagc ugugucaggg ucucuucuuu agagucgaag agaggaaaaa guggccagag     2460

cgacugagcg cacuugacaa uuugcugaac cauuccucua uguucuuaaa gggcgcucgc     2520

cucauacccg aaauggauca aauuuuuacg gagguugaaa ugacaacccu ggagaaagug     2580

aucaaugaaa cuugggccug gaagaacgcc acccuugcug agcaggcaaa acugccugcc     2640

acagagaagc ccguauugcu cucgaaagac aucgaagcga agaugauggc ucuggaucgg     2700

gaggugcagu accuacugaa uaaggccaaa uucaccaagc caagaccuag gcccaaagac     2760

aagaacggga cucgugcaga accaccgcuc aaugccagcg cuuccgauca gggagagaaa     2820

gucauuccuc ccgcaggcca aacagaagac gccgagccaa ucucagagcc cgaaaaggug     2880

gagacgggua gugaaccugg ggauaccgag ccacuggaac uuggcggacc cggcgcggag     2940

ccugagcaga aggaacaguc uacugggcaa aaacgcccgu ugaagaacga cgagcuguga     3000


<210>  7606
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7606
auggccgaca aggugagaag acagagaccc agaagaagag ugugcugggc ccugguggcc       60

gugcugcugg ccgaccugcu ggcccugagc gacacccugg ccgugaugag cguggaccug      120

ggcagcgaga gcaugaaggu ggccaucgug aagcccggcg ugcccaugga gaucgugcug      180

aacaaggaga gcagaagaaa gacccccgug aucgugaccc ugaaggagaa cgagagauuc      240

uucggcgaca gcgccgccag cauggccauc aagaacccca aggccacccu gagauacuuc      300

cagcaccugc ugggcaagca ggccgacaac ccccacgugg cccuguacca ggccagauuc      360

cccgagcacg agcugaccuu cgacccccag agacagaccg ugcacuucca gaucagcagc      420

cagcugcagu ucagccccga ggaggugcug ggcauggugc ugaacuacag cagaagccug      480

gccgaggacu ucgccgagca gcccaucaag gacgccguga ucaccgugcc cguguucuuc      540

aaccaggccg agagaagagc cgugcugcag gccgccagaa uggccggccu gaaggugcug      600

cagcugauca acgacaacac cgccaccgcc cugagcuacg gcguguucag aagaaaggac      660

aucaacacca ccgcccagaa caucauguuc uacgacaugg gcagcggcag caccgugugc      720

accaucguga ccuaccagau ggugaagacc aaggaggccg gcaugcagcc ccagcugcag      780

aucagaggcg ugggcuucga cagaacccug ggcggccugg agauggagcu gagacugaga      840

gagagacugg ccggccuguu caacgagcag agaaagggcc agagagccaa ggacgugaga      900

gagaacccca gagccauggc caagcugcug agagaggcca acagacugaa gaccgugcug      960

agcgccaacg ccgaccacau ggcccagauc gagggccuga uggacgacgu ggacuucaag     1020

gccaagguga ccagagugga guucgaggag cugugcgccg accuguucga gagagugccc     1080

ggccccgugc agcaggcccu gcagagcgcc gagaugagcc uggacgagau cgagcaggug     1140

auccuggugg gcggcgccac cagagugccc agagugcagg aggugcugcu gaaggccgug     1200

ggcaaggagg agcugggcaa gaacaucaac gccgacgagg ccgccgccau gggcgccgug     1260

uaccaggccg ccgcccugag caaggccuuc aaggugaagc ccuucguggu gagagacgcc     1320

gugguguacc ccauccuggu ggaguucacc agagaggugg aggaggagcc cggcauccac     1380

agccugaagc acaacaagag agugcuguuc agcagaaugg gccccuaccc ccagagaaag     1440

gugaucaccu ucaacagaua cagccacgac uucaacuucc acaucaacua cggcgaccug     1500

ggcuuccugg gccccgagga ccugagagug uucggcagcc agaaccugac caccgugaag     1560

cugaagggcg ugggcgacag cuucaagaag uaccccgacu acgagagcaa gggcaucaag     1620

gcccacuuca accuggacga gagcggcgug cugagccugg acagagugga gagcguguuc     1680

gagacccugg uggaggacag cgccgaggag gagagcaccc ugaccaagcu gggcaacacc     1740

aucagcagcc uguucggcgg cggcaccacc cccgacgcca aggagaacgg caccgacacc     1800

gugcaggagg aggaggagag ccccgccgag ggcagcaagg acgagcccgg cgagcaggug     1860

gagcugaagg aggaggccga ggcccccgug gaggacggca gccagccccc cccccccgag     1920

cccaagggcg acgccacccc cgagggcgag aaggccaccg agaaggagaa cggcgacaag     1980

agcgaggccc agaagcccag cgagaaggcc gaggccggcc ccgagggcgu ggcccccgcc     2040

cccgagggcg agaagaagca gaagcccgcc agaaagagaa gaauggugga ggagaucggc     2100

guggagcugg uggugcugga ccugcccgac cugcccgagg acaagcuggc ccagagcgug     2160

cagaagcugc aggaccugac ccugagagac cuggagaagc aggagagaga gaaggccgcc     2220

aacagccugg aggccuucau cuucgagacc caggacaagc uguaccagcc cgaguaccag     2280

gaggugagca ccgaggagca gagagaggag aucagcggca agcugagcgc cgccagcacc     2340

uggcuggagg acgagggcgu gggcgccacc accgugaugc ugaaggagaa gcuggccgag     2400

cugagaaagc ugugccaggg ccuguucuuc agaguggagg agagaaagaa guggcccgag     2460

agacugagcg cccuggacaa ccugcugaac cacagcagca uguuccugaa gggcgccaga     2520

cugauccccg agauggacca gaucuucacc gagguggaga ugaccacccu ggagaaggug     2580

aucaacgaga ccugggccug gaagaacgcc acccuggccg agcaggccaa gcugcccgcc     2640

accgagaagc ccgugcugcu gagcaaggac aucgaggcca agaugauggc ccuggacaga     2700

gaggugcagu accugcugaa caaggccaag uucaccaagc ccagacccag acccaaggac     2760

aagaacggca ccagagccga gcccccccug aacgccagcg ccagcgacca gggcgagaag     2820

gugauccccc ccgccggcca gaccgaggac gccgagccca ucagcgagcc cgagaaggug     2880

gagaccggca gcgagcccgg cgacaccgag ccccuggagc ugggcggccc cggcgccgag     2940

cccgagcaga aggagcagag caccggccag aagagacccc ugaagaacga cgagcuguga     3000


<210>  7607
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7607
auggccgaca aggugagacg gcagcgcccc agacggcgcg ucugcugggc ucugguugcc       60

gugcuccugg cggaucuucu ggcucucagc gacacccugg ccgugauguc cgucgaucuu      120

ggcucugaga gcaugaaagu ggccaucguu aagccugggg ugccgaugga aaucguccug      180

aacaaagagu ccagacggaa gacacccgug aucguuacgc ucaaagaaaa ugagcgcuuc      240

uuuggagacu cugcugccag cauggcuauu aagaacccua aggccacccu gagauacuuc      300

caacaucugc ucggcaaaca ggcggauaau ccccacgugg cccuguauca ggcucgguuu      360

ccugaacacg agcuuacauu cgacccccag cgccaaaccg uccauuuuca gaucuccucu      420

cagcugcagu ucagcccuga ggaagugcuc gggauggugc ugaacuacuc cagaagccuu      480

gccgaggauu uugcugaaca accgauuaag gacgccguca ucacaguucc cguguucuuu      540

aaucaggcgg agcggcgcgc cgugcugcag gcugccagaa uggcuggacu caaaguccug      600

cagcugauca acgauaauac cgccacagcc cucucuuaug gcguguuccg gcgcaaggac      660

auuaacacca cggcucaaaa uaucauguuu uacgauaugg gguccggaag caccguuugu      720

acaauuguga ccuaucagau ggucaaaaca aaggaggcgg gcaugcagcc ucaacugcag      780

aucagaggcg ugggguucga ccggacccuu ggaggccugg aaauggagcu cagacugcgc      840

gaacggcuug ccgggcuguu uaacgagcag agaaagggac agcgcgcuaa agauguucgg      900

gaaaauccca gagccauggc caagcuccug cgcgaggcua accggcugaa aacggugcuc      960

ucugccaaug cggaccacau ggcucaaauu gagggccuga uggacgaugu cgacuucaag     1020

gccaaaguga caagagucga guucgaggaa cuuugcgccg aucuguuuga gcgcgugccu     1080

gggcccguuc agcaggcucu ccaguccgcc gaaaugagcc uggacgagau cgagcaagug     1140

auucuugucg gaggcgcuac ccgggugccg agaguucagg aagugcugcu caaggccguc     1200

ggcaaagagg aacuggggaa gaacaucaau gcggaugagg ccgcugccau gggagcugug     1260

uaccaggccg cggcccuguc uaaggcuuuc aaagugaagc cuuuuguugu ccgcgacgcc     1320

gugguguauc ccauccucgu cgaguucaca cgggaggugg aggaagaacc uggcauucau     1380

ucccugaaac acaacaagag aguucuuuuu agccggaugg ggcccuaccc ccagcgcaaa     1440

gugaucaccu ucaacagaua cucccacgau uuuaauuucc auauuaacua uggagaccug     1500

ggcuuucucg ggccugaaga ucugcggguc uucggaucuc aaaaucugac cacagugaag     1560

cucaagggcg uuggcgacag cuuuaaaaag uacccggauu augaguccaa agggaucaag     1620

gcucacuuca accucgacga gagcggagug cugucucugg acagagucga auccguguuu     1680

gagacgcucg uugaagauag cgccgaggaa gagucuaccc ugacaaaacu uggcaauacc     1740

auuagcuccc uguucggggg aggcacaacc cccgacgcca aggagaacgg gacggauaca     1800

gugcaggaag aggaagaguc uccugcugaa ggcagcaagg acgagcccgg agagcagguc     1860

gaacucaaag aggaagcgga ggccccugug gaagauggcu cccagccccc gccucccgag     1920

ccuaaggggg acgcuacccc cgagggagaa aaagccaccg agaaggaaaa uggcgauaaa     1980

agcgaggccc aaaagccuuc ugagaaggcu gaagccgggc ccgagggagu ggcgccggcu     2040

ccugaaggcg agaaaaagca gaaacccgcc cgcaagcgga gaauggucga agagaucggg     2100

guugagcugg uggugcugga ccuucccgau cucccugaag acaaacuggc ccaguccguc     2160

caaaagcugc aggaucucac acugcgcgac cuugagaaac aggaaagaga gaaggcugcc     2220

aacagccugg aagcguucau cuuugagacc caggauaagc ucuaccaacc ggaguaucag     2280

gaagugucua cagaggaaca gcgggaggaa auuuccggca aacugagcgc ugccuccacg     2340

uggcuggagg acgagggagu uggcgccacc acagugaugc uuaaggaaaa acucgcugag     2400

cugcgcaagc ugugucaggg gcuuuucuuu agagucgaag aacggaaaaa guggcccgag     2460

cgccugucug cccuugacaa ucugcucaac cauagcucca uguuccugaa gggagcuaga     2520

cugaucccug aaauggauca aauuuuuacc gagguggaaa ugacaacccu ugagaaaguu     2580

aucaaugaaa cgugggccug gaagaacgcg acccucgccg agcaggcuaa acugcccgcc     2640

acagagaagc cugugcugcu cucuaaagac auugaagcua agaugauggc ccuggaucgg     2700

gagguccagu accuucugaa uaaggccaaa uucaccaagc cccgcccuag acccaaagac     2760

aagaacggca cacgggcuga accgccucuc aaugcgagcg ccuccgauca gggggagaaa     2820

gugauucccc cugcuggaca aaccgaagac gccgagccca ucagcgagcc ggaaaagguu     2880

gagacgggcu cugaaccugg ggauacagag ccccuggaac ugggcggacc uggcgccgag     2940

cccgagcaga aggaacaguc caccgggcaa aaacgccccc uuaagaacga cgagcuguga     3000


<210>  7608
<211>  3000
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       GRP170_(ORP150)__Homo_sapiens__AAC50947

<400>  7608
auggcagaca aaguaagacg acaaagaccu aggagaagag uuuguugggc auuaguugca       60

guacuauuag cagaucuauu agcucuaucu gauacuuuag cuguuaugag ugucgaucuu      120

ggaagugagu caaugaaagu agcaauagua aaaccaggug uaccaaugga gauaguucua      180

aauaaagaaa guagaagaaa aacgccagua aucgucacuc uaaaagaaaa cgaaagauuu      240

uucggugacu cggcagcaag cauggcaauu aaaaauccua aagcaaccuu aagauacuuc      300

caacaucuuc uuggaaaaca ggcagauaac ccacaugugg cacuauauca ggcaagauuc      360

cccgaacaug aauuaacauu cgauccacaa cgacagacgg uacacuuuca aauuucauca      420

caauuacaau uuucacccga agaaguacuu ggaaugguac uaaacuauag cagaucauug      480

gcugaggauu uugcugaaca accaauaaaa gaugcaguaa uaacagugcc cguauucuuu      540

aaccaagcag aaagaagggc aguacuacaa gcugcaagaa uggccggauu aaagguacuu      600

caacuaauaa augauaauac ugcaacagca uugucauacg gugucuuccg aagaaaagau      660

auaaacacaa cagcccaaaa uauaauguuu uaugauaugg guucaggguc caccguaugc      720

acuauuguua cauaccagau gguaaaaaca aaagaagcag guaugcaacc acaguugcag      780

auacgaggag uaggauuuga ccguacacua gguggauugg aaauggaacu gaggcuacga      840

gaaagauugg cggguuuauu uaaugaacaa cgcaaagguc aacgggcuaa agacguaaga      900

gaaaauccca gggcuauggc caagcuauua agagaagcaa auagacuaaa aacuguucug      960

ucagcaaacg cagaccauau ggcacaaaua gaaggucuaa uggaugacgu cgacuuuaaa     1020

gcgaaaguga cccggguuga auucgaagaa cucugugccg auuuauuuga acgagucccu     1080

ggaccaguuc aacaagcacu acaaagugca gaaaugucac uagacgaaau cgagcaagua     1140

auucuagugg gaggagcaac acgaguccca agaguccaag aaguccuacu uaaagccgua     1200

ggaaaagaag aacucggaaa aaauauaaau gcagacgaag cugcggcgau gggagcugua     1260

uaucaagcag cagcacuuag caaagcguuc aagguuaaac ccuucguagu gagagacgca     1320

guuguauacc ccauauuagu agaauucaca cgggaagucg aggaagaacc uggaauacau     1380

ucuuuaaaac auaauaaaag gguacuauuu aguagaaugg gaccauaccc acaaagaaaa     1440

guuauaacuu uuaaucgaua cagucaugac uuuaauuucc auauaaauua cggggaucua     1500

ggcuuccuag gaccagaaga ccugcgagua uucgggagcc aaaacuuaac cacagucaaa     1560

cuaaaaggag ucggagauag cuucaaaaaa uaucccgacu acgaaaguaa aggaauaaaa     1620

gcccacuuua auuuagauga aucaggaguu cuaaguuuag aucgugucga aagugucuuu     1680

gaaacacuug uagaagacag cgcagaggag gaaaguacgc uuaccaaacu agggaauaca     1740

auaucaaguc uauuuggagg ggggacaaca ccagaugcaa aagaaaaugg uacugacacc     1800

gugcaagaag aagaagaauc gccagccgaa ggaucgaaag acgaaccagg ggaacaaguc     1860

gaauuaaaag aagaagcaga agcaccaguu gaagauggua gccaaccgcc ucccccggaa     1920

ccuaaaggug acgcaacacc ugaaggagaa aaagcaacag aaaaagagaa uggugauaaa     1980

ucagaagcac aaaaaccuag ugaaaaagca gaagcggguc ccgaaggagu agcaccagca     2040

ccagaaggug aaaaaaaaca aaagccagca cgaaaaagaa gaaugguaga agaaauagga     2100

gucgaacuug ucguucuaga cuuaccggau uuaccagaag auaagcuagc acaaagugua     2160

caaaaauugc aagacuuaac ucuuagggac cuagaaaaac aggagcgcga aaaagcugca     2220

aauaguuuag aagcauuuau cuuugaaacg caagacaaac uguaccaacc agaauaucag     2280

gaaguaagua cugaagaaca aagagaagaa auuaguggaa aacugucagc agcuucaacu     2340

ugguuagaag augaaggagu uggagcuaca accgucaugc uuaaagaaaa acuagcugaa     2400

cuaagaaaau uaugucaagg cuuauucuuu aggguagaag aaagaaaaaa auggccugaa     2460

cgcuuauccg cauuagauaa uuugcuaaau cacucgagua uguuuuugaa aggugcucga     2520

uuaauccccg aaauggacca aauauucacu gaaguagaaa ugaccacauu agagaaagua     2580

auuaaugaaa caugggcaug gaaaaacgca accuuagccg aacaagcuaa acuaccagcc     2640

acggagaaac cgguucuauu auccaaagac auagaagcga agaugauggc ccucgauaga     2700

gaaguacagu auuuauugaa caaagcaaaa uuuacaaaac caagacccag gcccaaagau     2760

aaaaacggua caagagcaga accaccgcua aacgcaucag caucagacca aggagagaaa     2820

guaauacccc cagccggaca aacagaagac gcagaaccaa uaagugaacc agaaaaaguu     2880

gagaccggau cagaaccugg agacacagaa ccauuagaac uaggaggccc cggcgcagaa     2940

ccugaacaaa aagaacaaag uacaggacaa aaaaggccgc uaaagaacga cgaguuauaa     3000


<210>  7609
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GRP78_(BiP)__Homo_sapiens__P11021

<400>  7609

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  7610
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7610
augaagcucu cccugguggc cgcgaugcug cugcugcuca gcgcggcgcg ggccgaggag       60

gaggacaaga aggaggacgu gggcacggug gucggcaucg accuggggac caccuacucc      120

ugcgucggcg uguucaagaa cggccgcgug gagaucaucg ccaacgauca gggcaaccgc      180

aucacgccgu ccuaugucgc cuucacuccu gaaggggaac gucugauugg cgaugccgcc      240

aagaaccagc ucaccuccaa ccccgagaac acggucuuug acgccaagcg gcucaucggc      300

cgcacgugga augacccguc ugugcagcag gacaucaagu ucuugccguu caaggugguu      360

gaaaagaaaa cuaaaccaua cauucaaguu gauauuggag gugggcaaac aaagacauuu      420

gcuccugaag aaauuucugc caugguucuc acuaaaauga aagaaaccgc ugaggcuuau      480

uugggaaaga agguuaccca ugcaguuguu acuguaccag ccuauuuuaa ugaugcccaa      540

cgccaagcaa ccaaagacgc uggaacuauu gcuggccuaa auguuaugag gaucaucaac      600

gagccuacgg cagcugcuau ugcuuauggc cuggauaaga gggaggggga gaagaacauc      660

cugguguuug accugggugg cggaaccuuc gaugugucuc uucucaccau ugacaauggu      720

gucuucgaag uuguggccac uaauggagau acucaucugg guggagaaga cuuugaccag      780

cgugucaugg aacacuucau caaacuguac aaaaagaaga cgggcaaaga ugucaggaaa      840

gacaauagag cugugcagaa acuccggcgc gagguagaaa aggccaaacg ggcccugucu      900

ucucagcauc aagcaagaau ugaaauugag uccuucuaug aaggagaaga cuuuucugag      960

acccugacuc gggccaaauu ugaagagcuc aacauggauc uguuccgguc uacuaugaag     1020

cccguccaga aaguguugga agauucugau uugaagaagu cugauauuga ugaaauuguu     1080

cuuguuggug gcucgacucg aauuccaaag auucagcaac ugguuaaaga guucuucaau     1140

ggcaaggaac caucccgugg cauaaaccca gaugaagcug uagcguaugg ugcugcuguc     1200

caggcuggug ugcucucugg ugaucaagau acaggugacc ugguacugcu ugauguaugu     1260

ccccuuacac uugguauuga aacuguggga ggugucauga ccaaacugau uccaaggaac     1320

acaguggugc cuaccaagaa gucucagauc uuuucuacag cuucugauaa ucaaccaacu     1380

guuacaauca aggucuauga aggugaaaga ccccugacaa aagacaauca ucuucugggu     1440

acauuugauc ugacuggaau uccuccugcu ccucgugggg ucccacagau ugaagucacc     1500

uuugagauag augugaaugg uauucuucga gugacagcug aagacaaggg uacagggaac     1560

aaaaauaaga ucacaaucac caaugaccag aaucgccuga caccugaaga aaucgaaagg     1620

augguuaaug augcugagaa guuugcugag gaagacaaaa agcucaagga gcgcauugau     1680

acuagaaaug aguuggaaag cuaugccuau ucucuaaaga aucagauugg agauaaagaa     1740

aagcugggag guaaacuuuc cucugaagau aaggagacca uggaaaaagc uguagaagaa     1800

aagauugaau ggcuggaaag ccaccaagau gcugacauug aagacuucaa agcuaagaag     1860

aaggaacugg aagaaauugu ucaaccaauu aucagcaaac ucuauggaag ugcaggcccu     1920

cccccaacug gugaagagga uacagcagaa aaagaugagu uguag                     1965


<210>  7611
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7611
augaagcuga gccucguggc cgccaugcug cugcuccugu ccgcggcccg cgccgaggag       60

gaggacaaga aggaggacgu cggcaccgug guggggaucg accugggcac cacguacagc      120

ugcgucgggg uguucaagaa cggccgggug gagaucaucg ccaacgacca ggggaaccgc      180

aucacccccu ccuacgucgc cuucaccccg gagggcgagc ggcucaucgg cgacgcggcc      240

aagaaccagc ugaccagcaa ccccgagaac acgguguucg acgccaagcg ccugaucggg      300

cggaccugga acgaccccuc cgugcagcag gacaucaagu uccuccccuu caaggucgug      360

gagaagaaga ccaagccgua cauccaggug gacaucggcg ggggccagac caagacguuc      420

gcccccgagg agaucagcgc gaugguccug accaagauga aggagaccgc cgaggccuac      480

cuggggaaga aggugaccca cgccgugguc acggugcccg ccuacuucaa cgacgcgcag      540

cgccaggcca ccaaggacgc cggcaccauc gccggccuca acgugaugcg gaucaucaac      600

gagcccaccg ccgcggccau cgccuacggg cuggacaagc gcgagggcga gaagaacauc      660

cuggucuucg accucggggg cggcacguuc gacguguccc ugcugaccau cgacaacggg      720

guguucgagg ucguggccac caacggcgac acccaccucg ggggcgagga cuucgaccag      780

cgggugaugg agcacuucau caagcuguac aagaagaaga cggggaagga cguccgcaag      840

gacaaccggg ccgugcagaa gcugcgccgg gaggucgaga aggcgaagcg cgcccucagc      900

ucccagcacc aggcccggau cgagaucgag agcuucuacg agggcgagga cuucuccgag      960

acccugaccc gcgccaaguu cgaggagcug aacauggacc ucuuccggag caccaugaag     1020

ccggugcaga aggugcugga ggacuccgac cugaagaagu ccgacaucga cgagaucguc     1080

cucgugggcg ggagcacgcg cauccccaag auccagcagc uggugaagga guucuucaac     1140

ggcaaggagc ccagccgggg gaucaacccc gacgaggccg ucgcguacgg cgccgccgug     1200

caggccgggg ugcuguccgg cgaccaggac accggcgacc ucguccugcu ggacgugugc     1260

ccgcucaccc uggggaucga gaccgugggc ggggucauga cgaagcugau cccccgcaac     1320

accguggugc ccaccaagaa gucccagauc uucagcaccg cgagcgacaa ccagcccacg     1380

gucaccauca agguguacga gggcgagcgg ccgcucacca aggacaacca ccuccugggg     1440

accuucgacc ugacgggcau cccgcccgcg ccccgcggcg ugccccagau cgaggucacc     1500

uucgagaucg acgugaacgg gauccugcgc gugaccgccg aggacaaggg caccgggaac     1560

aagaacaaga ucaccaucac gaacgaccag aaccggcuga cccccgagga gaucgagcgc     1620

auggucaacg acgccgagaa guucgccgag gaggacaaga agcucaagga gcggaucgac     1680

acccgcaacg agcuggagag cuacgccuac ucccugaaga accagaucgg cgacaaggag     1740

aagcucggcg ggaagcugag cuccgaggac aaggagacca uggagaaggc cguggaggag     1800

aagaucgagu ggcuggagag ccaccaggac gccgacaucg aggacuucaa ggccaagaag     1860

aaggagcucg aggagaucgu gcagcccauc aucuccaagc uguacggcag cgccgggccc     1920

ccgcccacgg gcgaggagga caccgcggag aaggacgagc uguga                     1965


<210>  7612
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7612
augaagcucu cccucgucgc cgccaugcuc cuccuccucu ccgccgcccg cgccgaggag       60

gaggacaaga aggaggacgu cggcaccguc gucggcaucg accucggcac caccuacucc      120

ugcgucggcg ucuucaagaa cggccgcguc gagaucaucg ccaacgacca gggcaaccgc      180

aucacccccu ccuacgucgc cuucaccccc gagggcgagc gccucaucgg cgacgccgcc      240

aagaaccagc ucaccuccaa ccccgagaac accgucuucg acgccaagcg ccucaucggc      300

cgcaccugga acgaccccuc cguccagcag gacaucaagu uccuccccuu caaggucguc      360

gagaagaaga ccaagcccua cauccagguc gacaucggcg gcggccagac caagaccuuc      420

gcccccgagg agaucuccgc caugguccuc accaagauga aggagaccgc cgaggccuac      480

cucggcaaga aggucaccca cgccgucguc accguccccg ccuacuucaa cgacgcccag      540

cgccaggcca ccaaggacgc cggcaccauc gccggccuca acgucaugcg caucaucaac      600

gagcccaccg ccgccgccau cgccuacggc cucgacaagc gcgagggcga gaagaacauc      660

cucgucuucg accucggcgg cggcaccuuc gacgucuccc uccucaccau cgacaacggc      720

gucuucgagg ucgucgccac caacggcgac acccaccucg gcggcgagga cuucgaccag      780

cgcgucaugg agcacuucau caagcucuac aagaagaaga ccggcaagga cguccgcaag      840

gacaaccgcg ccguccagaa gcuccgccgc gaggucgaga aggccaagcg cgcccucucc      900

ucccagcacc aggcccgcau cgagaucgag uccuucuacg agggcgagga cuucuccgag      960

acccucaccc gcgccaaguu cgaggagcuc aacauggacc ucuuccgcuc caccaugaag     1020

cccguccaga agguccucga ggacuccgac cucaagaagu ccgacaucga cgagaucguc     1080

cucgucggcg gcuccacccg cauccccaag auccagcagc ucgucaagga guucuucaac     1140

ggcaaggagc ccucccgcgg caucaacccc gacgaggccg ucgccuacgg cgccgccguc     1200

caggccggcg uccucuccgg cgaccaggac accggcgacc ucguccuccu cgacgucugc     1260

ccccucaccc ucggcaucga gaccgucggc ggcgucauga ccaagcucau cccccgcaac     1320

accgucgucc ccaccaagaa gucccagauc uucuccaccg ccuccgacaa ccagcccacc     1380

gucaccauca aggucuacga gggcgagcgc ccccucacca aggacaacca ccuccucggc     1440

accuucgacc ucaccggcau cccccccgcc ccccgcggcg ucccccagau cgaggucacc     1500

uucgagaucg acgucaacgg cauccuccgc gucaccgccg aggacaaggg caccggcaac     1560

aagaacaaga ucaccaucac caacgaccag aaccgccuca cccccgagga gaucgagcgc     1620

auggucaacg acgccgagaa guucgccgag gaggacaaga agcucaagga gcgcaucgac     1680

acccgcaacg agcucgaguc cuacgccuac ucccucaaga accagaucgg cgacaaggag     1740

aagcucggcg gcaagcucuc cuccgaggac aaggagacca uggagaaggc cgucgaggag     1800

aagaucgagu ggcucgaguc ccaccaggac gccgacaucg aggacuucaa ggccaagaag     1860

aaggagcucg aggagaucgu ccagcccauc aucuccaagc ucuacggcuc cgccggcccc     1920

ccccccaccg gcgaggagga caccgccgag aaggacgagc ucuga                     1965


<210>  7613
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7613
augaagcuga gccucguggc cgcuaugcuu cuguuguuau ccgcagccag agcggaggaa       60

gaggacaaaa aggaagaugu cggcaccguu guggggaucg accugggaac aacuuacucu      120

ugcguaggug uguucaaaaa cggcaggguc gagauuauag cuaaugauca ggggaaccgg      180

aucacgcccu cauauguggc cuuuaccccu gaaggagagc gccuaauugg cgacgcagcc      240

aagaaucaac ucacaaguaa cccagagaau acuguuuucg augcuaaacg acugaucggu      300

cguaccugga acgacccgag cgugcagcag gauauuaagu uucuucccuu caaggucgug      360

gaaaagaaga caaaaccuua cauccaggua gacauagggg gaggccaaac caagacuuuu      420

gcaccagagg aaaucuccgc caugguucug acaaaaauga aggagaccgc ugaggccuau      480

uugggcaaga aagugacgca cgcggucgug acugugcccg cauacuucaa ugaugcccag      540

agacaggcua ccaaggacgc cgggacaauu gcaggacuca acgucaugag gaucauuaau      600

gaaccuacug cugccgcgau cgccuauggu cuggauaaac gggagggcga aaagaacaua      660

cugguuuuug accucggggg aggcaccuuc gaugugucuu uacugacaau ugacaauggu      720

guauuugagg uggucgcaac caacggggac acgcaucuug gaggcgaaga uuucgaccag      780

cgcgugaugg agcacuuuau caaauuguac aagaaaaaga cuggcaagga uguuagaaaa      840

gacaauaggg cugugcaaaa gcugcggcgc gaggucgaaa aagccaagcg agcucuaucg      900

ucacagcauc aggccagaau ugagaucgaa ucuuucuaug agggggaaga uuuuagugag      960

acacucacca gggcaaaauu cgaggaacug aacauggacc uuuuccgguc cacuaugaag     1020

ccagugcaga agguacugga ggauucugac uugaaaaaga gcgauaucga cgaaauuguu     1080

cucgugggag guuccacacg uauacccaaa auccaacagc uggucaagga guuuuucaau     1140

ggcaaagaac cuucacgcgg gauuaaccca gaugaggccg uggcuuacgg agcggcaguc     1200

caggccggcg uguuaagugg ugaccaagac accggggauc ugguucuccu ugacgugugu     1260

ccgcugacgu ugggcaucga gaccguagga ggcgucauga caaagcuaau acccagaaac     1320

acugugguuc cuaccaagaa aagccagauu uuuagcacag cuuccgauaa ucagccaacu     1380

gugaccauca aggucuacga aggggagagg ccccugacaa aagacaacca ccuccuggga     1440

accuucgauc uuacugguau cccuccagca ccccggggcg ugccgcagau ugaaguaacg     1500

uuugagaucg acgugaaugg gauucugcga guuacagccg aggauaaggg aaccggcaac     1560

aaaaauaaga uaacuaucac caacgaccaa aaucgcuuga caccugaaga gauugaaaga     1620

auggucaacg augccgagaa guucgcugaa gaggacaaaa agcucaaaga gaggaucgau     1680

acccggaaug aacuggaguc auaugccuac agcuuaaaga accagaucgg ugacaaagaa     1740

aagcuagggg gcaaacugag uucugaggau aaggaaacua uggagaaggc aguggaggag     1800

aaaauugaau ggcucgaauc ccaucaggac gcggacauag aggauuuuaa ggcuaaaaag     1860

aaagaacugg aggagaucgu gcagcccauu aucagcaaac uuuauggauc ggccggccca     1920

ccucccacag gggaagagga cacggcagaa aaggaugagu uguga                     1965


<210>  7614
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7614
augaagcuga gccugguggc cgccaugcug cugcugcuga gcgccgccag agccgaggag       60

gaggacaaga aggaggacgu gggcaccgug gugggcaucg accugggcac caccuacagc      120

ugcgugggcg uguucaagaa cggcagagug gagaucaucg ccaacgacca gggcaacaga      180

aucaccccca gcuacguggc cuucaccccc gagggcgaga gacugaucgg cgacgccgcc      240

aagaaccagc ugaccagcaa ccccgagaac accguguucg acgccaagag acugaucggc      300

agaaccugga acgaccccag cgugcagcag gacaucaagu uccugcccuu caagguggug      360

gagaagaaga ccaagcccua cauccaggug gacaucggcg gcggccagac caagaccuuc      420

gcccccgagg agaucagcgc cauggugcug accaagauga aggagaccgc cgaggccuac      480

cugggcaaga aggugaccca cgccguggug accgugcccg ccuacuucaa cgacgcccag      540

agacaggcca ccaaggacgc cggcaccauc gccggccuga acgugaugag aaucaucaac      600

gagcccaccg ccgccgccau cgccuacggc cuggacaaga gagagggcga gaagaacauc      660

cugguguucg accugggcgg cggcaccuuc gacgugagcc ugcugaccau cgacaacggc      720

guguucgagg ugguggccac caacggcgac acccaccugg gcggcgagga cuucgaccag      780

agagugaugg agcacuucau caagcuguac aagaagaaga ccggcaagga cgugagaaag      840

gacaacagag ccgugcagaa gcugagaaga gagguggaga aggccaagag agcccugagc      900

agccagcacc aggccagaau cgagaucgag agcuucuacg agggcgagga cuucagcgag      960

acccugacca gagccaaguu cgaggagcug aacauggacc uguucagaag caccaugaag     1020

cccgugcaga aggugcugga ggacagcgac cugaagaaga gcgacaucga cgagaucgug     1080

cuggugggcg gcagcaccag aauccccaag auccagcagc uggugaagga guucuucaac     1140

ggcaaggagc ccagcagagg caucaacccc gacgaggccg uggccuacgg cgccgccgug     1200

caggccggcg ugcugagcgg cgaccaggac accggcgacc uggugcugcu ggacgugugc     1260

ccccugaccc ugggcaucga gaccgugggc ggcgugauga ccaagcugau ccccagaaac     1320

accguggugc ccaccaagaa gagccagauc uucagcaccg ccagcgacaa ccagcccacc     1380

gugaccauca agguguacga gggcgagaga ccccugacca aggacaacca ccugcugggc     1440

accuucgacc ugaccggcau cccccccgcc cccagaggcg ugccccagau cgaggugacc     1500

uucgagaucg acgugaacgg cauccugaga gugaccgccg aggacaaggg caccggcaac     1560

aagaacaaga ucaccaucac caacgaccag aacagacuga cccccgagga gaucgagaga     1620

auggugaacg acgccgagaa guucgccgag gaggacaaga agcugaagga gagaaucgac     1680

accagaaacg agcuggagag cuacgccuac agccugaaga accagaucgg cgacaaggag     1740

aagcugggcg gcaagcugag cagcgaggac aaggagacca uggagaaggc cguggaggag     1800

aagaucgagu ggcuggagag ccaccaggac gccgacaucg aggacuucaa ggccaagaag     1860

aaggagcugg aggagaucgu gcagcccauc aucagcaagc uguacggcag cgccggcccc     1920

ccccccaccg gcgaggagga caccgccgag aaggacgagc uguga                     1965


<210>  7615
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7615
augaagcuga gccucguggc cgcuaugcug cuucugcucu ccgccgcgag agcugaggaa       60

gaggacaaaa aggaagaugu cggcaccguu guggggaucg accugggaac aacguacucu      120

ugcgugggcg ucuucaaaaa cgggcgggug gagauuaucg ccaaugauca gggaaaccgc      180

auuaccccca gcuauguugc cuuuacaccu gaaggcgaga gacuuaucgg ggacgcugcc      240

aagaaucaac ugaccuccaa cccggagaau acaguguucg augcuaaacg gcucauugga      300

cgcaccugga acgaccccuc uguccagcag gauaucaagu uucugccuuu caaggugguu      360

gaaaagaaga caaaacccua cauccaggug gacauuggcg gcgggcaaac caagacguuu      420

gccccugagg aaaucagcgc gaugguccug accaaaauga aggagacagc cgaggcuuau      480

cucggaaaga aagugaccca cgccgugguc acaguucccg cuuacuucaa ugaugcccag      540

agacaggcga ccaaggacgc cggcacgauu gcugggcuga acgugaugcg gaucauuaau      600

gaaccuacag ccgcugccau cgccuaugga cuugauaaac gcgagggcga aaagaacauu      660

cugguguuug accucggggg aggcaccuuc gaugucuccc ugcuuacaau cgacaauggc      720

guguuugagg uuguggcuac caacggggac acccaucugg gaggcgaaga uuucgaccag      780

agagucaugg agcacuuuau caaacucuac aagaaaaaga cagggaagga ugugcggaaa      840

gacaaucgcg cgguucaaaa gcugagacgg gagguggaaa aagccaagcg cgcucugucu      900

agccagcauc aggccagaau ugagaucgaa uccuucuaug agggagaaga uuuuagcgag      960

acgcucaccc gggccaaauu cgaggaacug aacauggacc uuuuccgcuc uacaaugaag     1020

ccgguccaga aggugcugga ggauuccgac cucaaaaaga gcgauauuga cgaaaucguc     1080

cuggugggcg ggucuacccg gauucccaaa auccaacagc uuguuaagga guuuuucaau     1140

ggaaaagaac cuuccagagg caucaacccc gaugaggcug uggccuacgg cgcggcuguc     1200

caggccgggg ugcugagcgg agaccaagac acaggcgauc ucguucugcu ggacgugugu     1260

ccucucaccc uggggauuga gacggucgga ggcgugauga caaaacuuau ccccagaaac     1320

accgugguuc cgaccaagaa aucucagauc uuuuccacag ccagcgauaa ucagccuacc     1380

gucacaauua agguguacga aggggagcgc ccccugacga aagacaacca ccuccugggc     1440

accuucgauc uuacaggcau uccucccgcu ccccggggag ugccucagau cgaagucacc     1500

uuugagaucg acgugaaugg gauucugaga guuacagccg aggauaaggg aaccggcaac     1560

aaaaauaaga ucacgauuac caacgaccaa aaucgccuca caccggaaga gaucgaacgg     1620

auggugaacg augcugagaa guucgccgaa gaggacaaaa agcugaaaga gagaauugau     1680

acccgcaaug aacuggaguc cuaugcguac ucucucaaga accagaucgg ggacaaagaa     1740

aagcugggag gcaaacuuag cuccgaggau aaggaaacaa uggagaaggc cgucgaggag     1800

aaaauugaau ggcuggaaag ccaucaggac gcugacaucg aggauuuuaa ggccaaaaag     1860

aaagaacucg aggagaucgu gcagcccauu aucucuaagc uguauggguc cgcuggcccu     1920

cccccuaccg gagaagagga cacggccgaa aaggaugagc uguga                     1965


<210>  7616
<211>  1965
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       GRP78_(BiP)__Homo_sapiens__AAF42836

<400>  7616
augaaacuau cauuaguagc cgcaaugcuu uuacuucuaa gcgcagcccg ugccgaagaa       60

gaagauaaaa aagaagaugu aggaacagua gucggaauag auuuaggaac aacauauagc      120

uguguagggg ucuuuaaaaa cggaagagua gaaauuaucg caaaugacca aggaaauaga      180

auaacaccuu cauauguugc auuuacacca gaaggagaac gauuaauugg agacgcugcu      240

aaaaaucaac uaacuucuaa uccagaaaac acaguguucg acgcaaaaag auuaauagga      300

aggacaugga augauccaag uguacaacaa gacauaaaau uccuaccauu caaagucgua      360

gagaaaaaaa caaaaccaua cauacaagua gauauaggag ggggacaaac aaaaacauuc      420

gcccccgaag agauaucagc aaugguauua accaaaauga aagaaacagc ggaagcauau      480

uuaggcaaaa aaguaacaca ugcaguagua accguacccg cauacuuuaa ugacgcccaa      540

agacaagcaa caaaagacgc aggaacaaua gcaggacuga auguaaugcg uauaauaaau      600

gaacccacag ccgcagcaau agcauacgga uuagauaaaa gagaaggaga aaaaaauauu      660

cucguguucg aucugggagg uggcacauuu gacguaaguc uauuaacaau agauaacgga      720

guuuucgaag uaguagcaac uaacggcgac acccauuuag gaggagaaga uuuugaccaa      780

cgaguaaugg aacacuucau aaaauuauau aaaaaaaaaa ccggaaaaga cgucagaaaa      840

gacaacagag cuguacaaaa acuacgaaga gaaguagaaa aagcuaaaag agcccuguca      900

agucaacacc aagcaagaau agaaauagaa uccuucuaug aaggagaaga cuucagcgaa      960

acacuaacca gagcaaaauu cgaagaacua aauauggacc ucuuuagaag cacaaugaaa     1020

ccaguacaaa aaguauuaga agauucggac uuaaaaaaau cagauauaga ugaaauagua     1080

cuaguuggag ggucaacaag aauaccaaag auacaacaac uuguaaaaga guucuuuaac     1140

ggaaaagaac caagcagggg aauaaaucca gacgaagcag uagcuuaugg agcagcagua     1200

caagcaggag uauuaagugg agaucaagau acaggagauc uaguacuauu agacguaugc     1260

ccauuaacuc ucggaauaga aacuguagga ggcguaauga caaaauuaau cccaagaaac     1320

accguagucc caacaaaaaa aucacaaaua uuuucaacag caagugacaa ccaaccaaca     1380

guuacaauaa agguuuacga aggagaaaga ccauuaacaa aagauaauca ccuauuagga     1440

acauuugacu uaacaggaau accaccugca cccagaggag ucccacaaau cgaaguaaca     1500

uuugaaauag auguaaacgg aauauuaagg gucacagcug aagauaaagg cacagguaac     1560

aaaaacaaaa uaacaauaac uaaugaccaa aauagauuaa caccagaaga aauagaaagg     1620

augguaaacg augcagaaaa auucgcagaa gaagacaaaa aauuaaaaga gagaaucgau     1680

acuagaaacg aacuugaauc uuacgcuuac agccuaaaaa aucaaauagg agacaaagaa     1740

aaacuuggcg gaaaacuauc uagcgaagac aaagaaacua uggaaaaagc gguagaggaa     1800

aaaauagaau gguuggaauc ucaucaagac gcagacauag aagacuucaa agcaaaaaaa     1860

aaagaacucg aagagauagu acaaccaaua aucaguaaac uauauggaag cgcaggacca     1920

ccuccaacgg gagaagaaga caccgcagaa aaagacgaac uauaa                     1965


<210>  7617
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GRP94_(gp96)__Homo_sapiens__P14625

<400>  7617

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  7618
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7618
augagggccc ugugggugcu gggccucugc ugcguccugc ugaccuucgg gucggucaga       60

gcugacgaug aaguugaugu ggaugguaca guagaagagg aucuggguaa aaguagagaa      120

ggaucaagga cggaugauga aguaguacag agagaggaag aagcuauuca guuggaugga      180

uuaaaugcau cacaaauaag agaacuuaga gagaagucgg aaaaguuugc cuuccaagcc      240

gaaguuaaca gaaugaugaa acuuaucauc aauucauugu auaaaaauaa agagauuuuc      300

cugagagaac ugauuucaaa ugcuucugau gcuuuagaua agauaaggcu aauaucacug      360

acugaugaaa augcucuuuc uggaaaugag gaacuaacag ucaaaauuaa gugugauaag      420

gagaagaacc ugcugcaugu cacagacacc gguguaggaa ugaccagaga agaguugguu      480

aaaaaccuug guaccauagc caaaucuggg acaagcgagu uuuuaaacaa aaugacugaa      540

gcacaggaag auggccaguc aacuucugaa uugauuggcc aguuuggugu cgguuucuau      600

uccgccuucc uuguagcaga uaagguuauu gucacuucaa aacacaacaa cgauacccag      660

cacaucuggg agucugacuc caaugaauuu ucuguaauug cugacccaag aggaaacacu      720

cuaggacggg gaacgacaau uacccuuguc uuaaaagaag aagcaucuga uuaccuugaa      780

uuggauacaa uuaaaaaucu cgucaaaaaa uauucacagu ucauaaacuu uccuauuuau      840

guauggagca gcaagacuga aacuguugag gagcccaugg aggaagaaga agcagccaaa      900

gaagagaaag aagaaucuga ugaugaagcu gcaguagagg aagaagaaga agaaaagaaa      960

ccaaagacua aaaaaguuga aaaaacuguc ugggacuggg aacuuaugaa ugauaucaaa     1020

ccaauauggc agagaccauc aaaagaagua gaagaagaug aauacaaagc uuucuacaaa     1080

ucauuuucaa aggaaaguga ugaccccaug gcuuauauuc acuuuacugc ugaaggggaa     1140

guuaccuuca aaucaauuuu auuuguaccc acaucugcuc cacguggucu guuugacgaa     1200

uauggaucua aaaagagcga uuacauuaag cucuaugugc gccguguauu caucacagac     1260

gacuuccaug auaugaugcc uaaauaccuc aauuuuguca aggguguggu ggacucagau     1320

gaucuccccu ugaauguuuc ccgcgagacu cuucagcaac auaaacugcu uaaggugauu     1380

aggaagaagc uuguucguaa aacgcuggac augaucaaga agauugcuga ugauaaauac     1440

aaugauacuu uuuggaaaga auuugguacc aacaucaagc uuggugugau ugaagaccac     1500

ucgaaucgaa cacgucuugc uaaacuucuu agguuccagu cuucucauca uccaacugac     1560

auuacuagcc uagaccagua uguggaaaga augaaggaaa aacaagacaa aaucuacuuc     1620

auggcugggu ccagcagaaa agaggcugaa ucuucuccau uuguugagcg acuucugaaa     1680

aagggcuaug aaguuauuua ccucacagaa ccuguggaug aauacuguau ucaggcccuu     1740

cccgaauuug augggaagag guuccagaau guugccaagg aaggagugaa guucgaugaa     1800

agugagaaaa cuaaggagag ucgugaagca guugagaaag aauuugagcc ucugcugaau     1860

uggaugaaag auaaagcccu uaaggacaag auugaaaagg cugugguguc ucagcgccug     1920

acagaaucuc cgugugcuuu gguggccagc caguacggau ggucuggcaa cauggagaga     1980

aucaugaaag cacaagcgua ccaaacgggc aaggacaucu cuacaaauua cuaugcgagu     2040

cagaagaaaa cauuugaaau uaaucccaga cacccgcuga ucagagacau gcuucgacga     2100

auuaaggaag augaagauga uaaaacaguu uuggaucuug cugugguuuu guuugaaaca     2160

gcaacgcuuc ggucagggua ucuuuuacca gacacuaaag cauauggaga uagaauagaa     2220

agaaugcuuc gccucaguuu gaacauugac ccugaugcaa agguggaaga agagccugaa     2280

gaagaaccug aagagacagc agaagacaca acagaagaca cagagcaaga cgaagaugaa     2340

gaaauggaug ugggaacaga ugaagaagaa gaaacagcaa aggaaucuac agcugaaaaa     2400

gaugaauugu aa                                                         2412


<210>  7619
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7619
augcgcgccc ugugggugcu cggccugugc ugcguccugc ucaccuucgg gagcgugcgg       60

gccgacgacg agguggacgu cgacggcacc guggaggagg accuggggaa gucccgcgag      120

ggcagccgga cggacgacga ggugguccag cgcgaggagg aggcgaucca gcuggacggg      180

cucaacgccu cccagauccg ggagcugcgc gagaaguccg agaaguucgc cuuccaggcc      240

gaggugaacc ggaugaugaa gcugaucauc aacagccucu acaagaacaa ggagaucuuc      300

cugcgcgagc ugaucagcaa cgccuccgac gcgcucgaca agauccggcu gaucagccug      360

accgacgaga acgcccucuc cggcaacgag gagcugaccg ugaagaucaa gugcgacaag      420

gagaagaacc ugcuccacgu caccgacacg ggcgugggga ugacccgcga ggagcuggug      480

aagaaccugg gcaccaucgc caagagcggg accuccgagu uccucaacaa gaugacggag      540

gcccaggagg acggccagag caccuccgag cugaucgggc aguucggcgu cggcuucuac      600

agcgcguucc ugguggccga caaggugauc gucaccucca agcacaacaa cgacacccag      660

cacaucuggg agagcgacuc caacgaguuc agcgugaucg ccgacccccg ggggaacacg      720

cucggccgcg ggaccaccau cacccuggug cugaaggagg aggccuccga cuaccucgag      780

cuggacacga ucaagaaccu ggucaagaag uacagccagu ucaucaacuu cccgaucuac      840

guguggagcu ccaagaccga gaccguggag gagcccaugg aggaggagga ggccgcgaag      900

gaggagaagg aggagagcga cgacgaggcc gccgucgagg aggaggagga ggagaagaag      960

cccaagacca agaaggugga gaagacggug ugggacuggg agcucaugaa cgacaucaag     1020

cccaucuggc agcggccguc caaggagguc gaggaggacg aguacaaggc cuucuacaag     1080

agcuucucca aggagagcga cgaccccaug gccuacaucc acuucaccgc ggagggcgag     1140

gugaccuuca aguccauccu guucgucccc accagcgcgc cccgcggccu guucgacgag     1200

uacgggucca agaaguccga cuacaucaag cucuacgugc ggcgcguguu caucacggac     1260

gacuuccacg acaugaugcc gaaguaccug aacuucguca agggcguggu ggacagcgac     1320

gaccugcccc ucaacgucag ccgggagacc cugcagcagc acaagcugcu caaggugauc     1380

cgcaagaagc uggugcggaa gacccuggac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucgggacg aacaucaagc ucggcgucau cgaggaccac     1500

uccaaccgca cccggcuggc caagcugcuc cgcuuccaga gcucccacca ccccaccgac     1560

aucaccagcc uggaccagua cguggagcgc augaaggaga agcaggacaa gaucuacuuc     1620

auggccgggu ccagccggaa ggaggccgag uccagccccu ucguggagcg ccugcucaag     1680

aagggcuacg aggucaucua ccugacggag ccgguggacg aguacugcau ccaggcccug     1740

cccgaguucg acggcaagcg guuccagaac guggccaagg agggggucaa guucgacgag     1800

agcgagaaga ccaaggaguc ccgcgaggcc guggagaagg aguucgagcc ccugcucaac     1860

uggaugaagg acaaggcccu gaaggacaag aucgagaagg cgguggucag ccagcggcug     1920

accgaguccc ccugcgcccu cguggccagc caguacggcu gguccgggaa cauggagcgc     1980

aucaugaagg cccaggcgua ccagaccggc aaggacauca gcacgaacua cuacgccucc     2040

cagaagaaga ccuucgagau caacccgcgg cacccccuga uccgcgacau gcugcggcgc     2100

aucaaggagg acgaggacga caagaccgug cucgaccugg ccgucgugcu guucgagacc     2160

gccacccucc ggagcgggua ccugcugccc gacacgaagg ccuacggcga ccgcaucgag     2220

cggaugcucc gccugucccu gaacaucgac cccgacgcga agguggagga ggagccggag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca cggagcagga cgaggacgag     2340

gagauggacg ucggcaccga cgaggaggag gagaccgcca aggagagcac cgccgagaag     2400

gacgagcucu ga                                                         2412


<210>  7620
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7620
augcgcgccc ucuggguccu cggccucugc ugcguccucc ucaccuucgg cuccguccgc       60

gccgacgacg aggucgacgu cgacggcacc gucgaggagg accucggcaa gucccgcgag      120

ggcucccgca ccgacgacga ggucguccag cgcgaggagg aggccaucca gcucgacggc      180

cucaacgccu cccagauccg cgagcuccgc gagaaguccg agaaguucgc cuuccaggcc      240

gaggucaacc gcaugaugaa gcucaucauc aacucccucu acaagaacaa ggagaucuuc      300

cuccgcgagc ucaucuccaa cgccuccgac gcccucgaca agauccgccu caucucccuc      360

accgacgaga acgcccucuc cggcaacgag gagcucaccg ucaagaucaa gugcgacaag      420

gagaagaacc uccuccacgu caccgacacc ggcgucggca ugacccgcga ggagcucguc      480

aagaaccucg gcaccaucgc caaguccggc accuccgagu uccucaacaa gaugaccgag      540

gcccaggagg acggccaguc caccuccgag cucaucggcc aguucggcgu cggcuucuac      600

uccgccuucc ucgucgccga caaggucauc gucaccucca agcacaacaa cgacacccag      660

cacaucuggg aguccgacuc caacgaguuc uccgucaucg ccgacccccg cggcaacacc      720

cucggccgcg gcaccaccau cacccucguc cucaaggagg aggccuccga cuaccucgag      780

cucgacacca ucaagaaccu cgucaagaag uacucccagu ucaucaacuu ccccaucuac      840

gucugguccu ccaagaccga gaccgucgag gagcccaugg aggaggagga ggccgccaag      900

gaggagaagg aggaguccga cgacgaggcc gccgucgagg aggaggagga ggagaagaag      960

cccaagacca agaaggucga gaagaccguc ugggacuggg agcucaugaa cgacaucaag     1020

cccaucuggc agcgccccuc caaggagguc gaggaggacg aguacaaggc cuucuacaag     1080

uccuucucca aggaguccga cgaccccaug gccuacaucc acuucaccgc cgagggcgag     1140

gucaccuuca aguccauccu cuucgucccc accuccgccc cccgcggccu cuucgacgag     1200

uacggcucca agaaguccga cuacaucaag cucuacgucc gccgcgucuu caucaccgac     1260

gacuuccacg acaugaugcc caaguaccuc aacuucguca agggcgucgu cgacuccgac     1320

gaccuccccc ucaacgucuc ccgcgagacc cuccagcagc acaagcuccu caaggucauc     1380

cgcaagaagc ucguccgcaa gacccucgac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucggcacc aacaucaagc ucggcgucau cgaggaccac     1500

uccaaccgca cccgccucgc caagcuccuc cgcuuccagu ccucccacca ccccaccgac     1560

aucaccuccc ucgaccagua cgucgagcgc augaaggaga agcaggacaa gaucuacuuc     1620

auggccggcu ccucccgcaa ggaggccgag uccucccccu ucgucgagcg ccuccucaag     1680

aagggcuacg aggucaucua ccucaccgag cccgucgacg aguacugcau ccaggcccuc     1740

cccgaguucg acggcaagcg cuuccagaac gucgccaagg agggcgucaa guucgacgag     1800

uccgagaaga ccaaggaguc ccgcgaggcc gucgagaagg aguucgagcc ccuccucaac     1860

uggaugaagg acaaggcccu caaggacaag aucgagaagg ccgucgucuc ccagcgccuc     1920

accgaguccc ccugcgcccu cgucgccucc caguacggcu gguccggcaa cauggagcgc     1980

aucaugaagg cccaggccua ccagaccggc aaggacaucu ccaccaacua cuacgccucc     2040

cagaagaaga ccuucgagau caacccccgc cacccccuca uccgcgacau gcuccgccgc     2100

aucaaggagg acgaggacga caagaccguc cucgaccucg ccgucguccu cuucgagacc     2160

gccacccucc gcuccggcua ccuccucccc gacaccaagg ccuacggcga ccgcaucgag     2220

cgcaugcucc gccucucccu caacaucgac cccgacgcca aggucgagga ggagcccgag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca ccgagcagga cgaggacgag     2340

gagauggacg ucggcaccga cgaggaggag gagaccgcca aggaguccac cgccgagaag     2400

gacgagcucu ga                                                         2412


<210>  7621
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7621
augagagccc ugugggugcu cggccuuugc uguguccugu ugaccuucgg gagcguuagg       60

gcugacgaug agguggacgu agauggaaca guggaagagg acuuagguaa gucccgggaa      120

ggcucucgca cugaugacga ggucgugcag cgagaagagg aggcaaucca acuggauggg      180

cuaaacgccu cacagauucg ugaacucaga gagaaaagug aaaaguuugc guuccaggcu      240

gagguuaaua ggaugaugaa acugauaauc aacagccuuu acaagaauaa agagauuuuu      300

cugcgggaau ugaucuccaa cgccucugac gcacucgaua agauucgccu gaucucgcug      360

acggacgaga augcccucuc aggaaacgaa gaguuaaccg ugaagauaaa augcgauaag      420

gagaaaaauc ugcuucacgu cacagacacu ggcgugggua ugaccagaga ggaguuggua      480

aagaaccugg ggacaaucgc uaaaagcgga accagugagu uccuaaauaa gaugacugaa      540

gcacaggaag auggccaauc cacaucugag cucauuggcc aguuuggggu uggauucuau      600

agcgccuuuc ugguggcuga caaggucauc gugaccucca aacauaacaa ugacacgcag      660

cacauuuggg aaucagauag uaacgaguuc agcgugaucg ccgaccccag ggguaauacu      720

cuuggccggg ggaccacaau aacucugguc uugaaggagg aagcgucuga uuaccucgag      780

cuggacacca uuaaaaacuu aguuaagaaa uauucccagu uuaucaauuu cccuauuuac      840

guguggucaa gcaagacaga aaccguagag gaaccaaugg aggaggaaga ggcagccaaa      900

gaagagaagg aggaaaguga ugacgaggcu gccguggaag aggaagagga ggaaaagaaa      960

ccgaagacga aaaaggucga gaaaacugug ugggauuggg aacugaugaa cgacaucaag     1020

cccaucuggc aacgcccuuc uaaggagguu gaagaggaug aguauaaagc auuuuacaag     1080

uccuucagca aagaaucgga cgauccaaug gcuuauauuc auuuuacagc cgagggagaa     1140

gugaccuuca agucuauacu cuucgucccc acuuccgcgc cucgaggccu uuuugacgag     1200

uacgguagua aaaagucaga cuacaucaag cuguauguga gaaggguauu cauuacagau     1260

gacuuucacg auaugaugcc aaaauacuug aacuucguua aggggguggu cgacagcgau     1320

gaccuacccc ugaauguguc ccgggaaacc cuccagcagc auaaacugcu uaaggucauc     1380

cguaaaaagc uggugcgcaa gacguuggau augauuaaaa agauagccga cgauaaauau     1440

aacgacaccu uuuggaagga guucggaaca aauaucaaac ucggcguuau cgaggaucac     1500

ucuaacagaa cuaggcuggc aaaguuacug cgguuucaga gcucacacca uccuaccgac     1560

auuacaaguc uagaucaaua cguggaacga augaaagaga agcaggacaa gaucuauuuc     1620

auggcuggcu ccagccgcaa agaagccgag ucuucaccau uuguagagag acuccugaag     1680

aaaggguacg aagucauuua ucuuacugag ccgguggacg aauacuguau acaggcuuug     1740

cccgaguucg auggaaagag guuucaaaau guugccaaag aaggugugaa guucgacgag     1800

agugagaaga ccaaagaaag ccgggaggca gucgaaaagg aguuugaacc ucugcucaac     1860

uggaugaaag auaaggcccu gaaagacaag aucgagaagg cugugguauc ccagcgccuu     1920

acagagucuc caugcgcgcu gguggcaucg caguacggcu ggagcgggaa uauggaaaga     1980

auuaugaaag cccaggcuua ucaaaccgga aaggauaucu ccacuaacua cuaugccuca     2040

cagaaaaaga cguucgagau caaucccagg cacccuuuga uucgugacau gcuccggcga     2100

auaaaagaag augaggacga uaagacaguu cuggacuuag cagucgugcu guucgaaacc     2160

gccacucuaa gaaguggcua ccuccugcca gauaccaagg cuuaugguga caggaucgag     2220

cgcaugcuuc gguugucucu gaacauugau cccgacgcca aaguggagga agaaccggaa     2280

gaggagccug aagagacagc agaagacacc acugaggaua cagaacagga cgaggaugag     2340

gaaauggacg ucgggacgga ugaggaagag gaaaccgcga aggagagcac ugcugagaaa     2400

gacgaacucu ga                                                         2412


<210>  7622
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7622
augagagccc ugugggugcu gggccugugc ugcgugcugc ugaccuucgg cagcgugaga       60

gccgacgacg agguggacgu ggacggcacc guggaggagg accugggcaa gagcagagag      120

ggcagcagaa ccgacgacga gguggugcag agagaggagg aggccaucca gcuggacggc      180

cugaacgcca gccagaucag agagcugaga gagaagagcg agaaguucgc cuuccaggcc      240

gaggugaaca gaaugaugaa gcugaucauc aacagccugu acaagaacaa ggagaucuuc      300

cugagagagc ugaucagcaa cgccagcgac gcccuggaca agaucagacu gaucagccug      360

accgacgaga acgcccugag cggcaacgag gagcugaccg ugaagaucaa gugcgacaag      420

gagaagaacc ugcugcacgu gaccgacacc ggcgugggca ugaccagaga ggagcuggug      480

aagaaccugg gcaccaucgc caagagcggc accagcgagu uccugaacaa gaugaccgag      540

gcccaggagg acggccagag caccagcgag cugaucggcc aguucggcgu gggcuucuac      600

agcgccuucc ugguggccga caaggugauc gugaccagca agcacaacaa cgacacccag      660

cacaucuggg agagcgacag caacgaguuc agcgugaucg ccgaccccag aggcaacacc      720

cugggcagag gcaccaccau cacccuggug cugaaggagg aggccagcga cuaccuggag      780

cuggacacca ucaagaaccu ggugaagaag uacagccagu ucaucaacuu ccccaucuac      840

guguggagca gcaagaccga gaccguggag gagcccaugg aggaggagga ggccgccaag      900

gaggagaagg aggagagcga cgacgaggcc gccguggagg aggaggagga ggagaagaag      960

cccaagacca agaaggugga gaagaccgug ugggacuggg agcugaugaa cgacaucaag     1020

cccaucuggc agagacccag caaggaggug gaggaggacg aguacaaggc cuucuacaag     1080

agcuucagca aggagagcga cgaccccaug gccuacaucc acuucaccgc cgagggcgag     1140

gugaccuuca agagcauccu guucgugccc accagcgccc ccagaggccu guucgacgag     1200

uacggcagca agaagagcga cuacaucaag cuguacguga gaagaguguu caucaccgac     1260

gacuuccacg acaugaugcc caaguaccug aacuucguga agggcguggu ggacagcgac     1320

gaccugcccc ugaacgugag cagagagacc cugcagcagc acaagcugcu gaaggugauc     1380

agaaagaagc uggugagaaa gacccuggac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucggcacc aacaucaagc ugggcgugau cgaggaccac     1500

agcaacagaa ccagacuggc caagcugcug agauuccaga gcagccacca ccccaccgac     1560

aucaccagcc uggaccagua cguggagaga augaaggaga agcaggacaa gaucuacuuc     1620

auggccggca gcagcagaaa ggaggccgag agcagccccu ucguggagag acugcugaag     1680

aagggcuacg aggugaucua ccugaccgag cccguggacg aguacugcau ccaggcccug     1740

cccgaguucg acggcaagag auuccagaac guggccaagg agggcgugaa guucgacgag     1800

agcgagaaga ccaaggagag cagagaggcc guggagaagg aguucgagcc ccugcugaac     1860

uggaugaagg acaaggcccu gaaggacaag aucgagaagg ccguggugag ccagagacug     1920

accgagagcc ccugcgcccu gguggccagc caguacggcu ggagcggcaa cauggagaga     1980

aucaugaagg cccaggccua ccagaccggc aaggacauca gcaccaacua cuacgccagc     2040

cagaagaaga ccuucgagau caaccccaga cacccccuga ucagagacau gcugagaaga     2100

aucaaggagg acgaggacga caagaccgug cuggaccugg ccguggugcu guucgagacc     2160

gccacccuga gaagcggcua ccugcugccc gacaccaagg ccuacggcga cagaaucgag     2220

agaaugcuga gacugagccu gaacaucgac cccgacgcca agguggagga ggagcccgag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca ccgagcagga cgaggacgag     2340

gagauggacg ugggcaccga cgaggaggag gagaccgcca aggagagcac cgccgagaag     2400

gacgagcugu ga                                                         2412


<210>  7623
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7623
augagagccc ugugggugcu cggccugugc uguguccuuc ugaccuucgg gagcguucgg       60

gcugacgaug agguggacgu ggauggaaca gucgaagagg accucggcaa gucccgcgaa      120

gggucuagaa cggaugacga ggugguucag cgggaagagg aggccaucca acuggaugga      180

cuuaacgcga gccagauucg cgaacugaga gagaaauccg aaaaguuugc uuuccaggcc      240

gaggugaauc ggaugaugaa acucaucauu aacucucugu acaagaauaa agagaucuuu      300

cugcgcgaac ucauuagcaa cgccuccgac gcucuggaua agaucagacu uaucucucug      360

accgacgaga augcccucag cggcaacgaa gaacugacag ucaagauuaa augcgauaag      420

gagaaaaauc uucugcacgu gaccgacaca gggguuggaa ugacccggga ggagcucgug      480

aagaaccugg gcacaaucgc uaaauccggc accagcgagu uccugaauaa gaugacggag      540

gcccaggaag augggcaauc uaccuccgag cucauuggac aguuuggcgu cggguucuau      600

agcgcguuuc ugguggccga caaggugauc gucacaucua aacauaacaa ugacacccag      660

cacauuuggg aauccgauag caacgaguuc ucuguuaucg cugacccccg cggaaauaca      720

cuuggcagag ggaccacgau uacacuggug cucaaggagg aagccuccga uuaccuggag      780

cuugacacca ucaaaaaccu ggugaagaaa uauagccagu uuaucaauuu cccuauuuac      840

gucugguccu cuaagacaga aaccguggag gaaccgaugg aggaggaaga ggcugccaaa      900

gaagagaagg aggaaagcga ugacgaggcg gccguugaag aggaagagga ggaaaagaaa      960

cccaagacca aaaaggugga gaaaacaguc ugggauuggg aacucaugaa cgacaucaag     1020

ccuauuuggc aacggcccuc caaggaggug gaagaggaug aguauaaagc cuuuuacaag     1080

agcuucucua aagaauccga cgauccuaug gcuuauaucc auuuuacggc ugagggagaa     1140

guuaccuuca agagcauucu guucgugccc acaucugccc cucgcggccu guuugacgag     1200

uacggcagca aaaaguccga cuacaucaag cucuauguca gacggguguu caucaccgau     1260

gacuuucacg auaugaugcc gaaauaccug aacuucguca aggggguggu ugacucugau     1320

gaccuucccc ugaaugugag ccgcgaaaca cuccagcagc auaaacugcu uaaggucauu     1380

cggaaaaagc uggugagaaa gacccucgau augaucaaaa agauugccga cgauaaauau     1440

aacgacacgu uuuggaagga guucggaaca aauaucaaac ugggcguuau ugaggaucac     1500

uccaacagaa cccgccuggc uaagcuccug cgguuucaga gcucucacca uccuaccgac     1560

aucacauccc uugaucaaua cguggaaaga augaaagaga agcaggacaa gaucuauuuc     1620

auggcgggga gcucucgcaa agaagccgag uccagccccu uugucgagcg gcugcucaag     1680

aaaggauacg aagugauuua ucugaccgag ccuguggacg aauacuguau ccaggcucug     1740

cccgaguucg auggcaagag auuucaaaau guugccaaag aaggggucaa guucgacgag     1800

uccgagaaga caaaagaauc ucgcgaggcc guggaaaagg aguuugaacc gcuucucaac     1860

uggaugaaag auaaggcucu gaaagacaag auugagaagg ccguggucag ccagcggcug     1920

acggaguccc cuugcgcgcu cguggcuucu caguacggau ggagcggcaa uauggaaaga     1980

aucaugaaag cccaggccua ucaaaccggc aaggauauuu ccacaaacua cuaugcuagc     2040

cagaaaaaga ccuucgagau caauccccgc cacccucuga uucgggacau gcuuagacgc     2100

aucaaagaag augaggacga uaagacaguu cuggaccucg ccgugguccu guucgaaacc     2160

gcuacgcugc ggucugggua ccuucucccc gauaccaagg ccuauggaga cagaaucgag     2220

cggaugcugc gccugucccu caacauugau cccgacgcga aaguggagga agaaccugaa     2280

gaggagccgg aagagacagc cgaagacacc acagaggaua ccgaacagga cgaggaugag     2340

gaaauggacg uuggcacgga ugaggaagag gaaacagcua aggagagcac cgccgagaaa     2400

gacgaacugu ga                                                         2412


<210>  7624
<211>  2412
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       GRP94_(gp96)__Homo_sapiens__AAH66656

<400>  7624
augagagcgc ucuggguacu aggauuaugu ugcguacuau uaacguuugg gucuguaaga       60

gcagacgaug agguagaugu agacggaacu guugaagaag auuuaggaaa aagccgagaa      120

ggaucaagaa cagaugacga agucguacaa agagaagaag aagcaauaca acuugaugga      180

cuaaacgcaa gucaaauaag agaauuaaga gaaaaaucag aaaaauuugc guuucaagca      240

gaaguaaaca gaaugaugaa acuaauaauc aacagucuau auaaaaacaa agaaauuuuc      300

uuaagagaac ucauaagcaa ugcuagugau gcacuagaua aaauacgauu aauaucauua      360

acagaugaaa augcacuaag cggaaaugag gaauuaacag uaaaaauaaa augcgauaaa      420

gaaaaaaacc uguuacaugu cacagauaca ggcguuggua ugacuagaga agaacuaguu      480

aaaaaucuug guacuauagc aaaaagugga acaucagaau uccuaaauaa aaugacagaa      540

gcacaagaag auggacaaag uacgucagaa cuaauaggac aauuuggagu gggauuuuau      600

uccgcauucc uaguagcgga caaagugaua gugacuagca aacacaacaa ugacacacaa      660

cauauauggg aaucagauag uaaugaguuc agugucaucg cugauccaag aggaaacaca      720

cuagguagag gaacaacuau aacacugguc cuaaaagaag aagccagcga uuaucuagaa      780

uuagacacua uaaaaaaucu aguuaaaaaa uacagccaau ucauaaacuu cccaauauac      840

guauggucca guaaaaccga aacaguugaa gaaccuaugg aagaagaaga agccgcgaaa      900

gaggaaaaag aagaaucaga ugacgaagca gcaguagaag aagaagaaga agagaaaaaa      960

ccaaaaacua agaaaguaga aaaaacggua ugggauuggg aacucaugaa ugacauaaaa     1020

ccaauauggc aaagaccauc uaaagaaguu gaagaagaug aauacaaggc auuuuauaaa     1080

ucauuuagca aagaaagcga ugauccaaug gcauauauac acuuuacagc agaaggagaa     1140

guaacuuuca aaucaauauu auucguaccg acaagugcuc caagaggauu auucgacgaa     1200

uauggaucaa aaaaaaguga cuauauuaaa cuauacguaa ggagaguauu cauaaccgau     1260

gauuuucacg auaugaugcc uaaauaccuc aacuucguaa aaggaguugu ggacucggac     1320

gacuuaccac uaaacguuag ccgagaaaca cuccaacaac acaaguuguu aaagguaaua     1380

cgcaaaaaac uuguaagaaa aacacuagau augauaaaaa agaucgcaga ugacaaauac     1440

aacgauacau ucuggaaaga auucgguaca aauauuaaac ucggagugau ugaagaucac     1500

aguaauagaa cgagauuagc aaaacuacuu agauuccagu caagucauca cccaacagac     1560

aucacgucac uagaccaaua ugucgaaaga augaaagaaa aacaagauaa gauauauuuu     1620

auggcaggau caucaagaaa agaagcagaa aguagcccuu uuguagaaag auuauugaaa     1680

aaaggauacg aaguaauaua uuuaaccgaa ccuguugacg aauauuguau ucaagcacuc     1740

cccgaauuug acggaaaaag auuccaaaau gucgccaaag aaggaguuaa auucgaugaa     1800

ucagaaaaaa caaaagaguc aagagaagca guagaaaaag aauucgaacc acuacuaaac     1860

uggaugaaag acaaagcauu aaaagauaaa auagaaaaag caguaguaag ccaaagauua     1920

acggaaucgc caugcgcacu aguagcauca caauacggau ggaguggcaa uauggaacga     1980

auaaugaaag cacaggccua ccaaacaggg aaagacauaa gcacaaauua uuacgcaagu     2040

caaaaaaaaa cauucgaaau caauccuagg cacccauuaa uucgagacau gcuaagaagg     2100

auaaaagaag augaagacga uaaaacggua cuagaucuag caguaguucu uuucgaaaca     2160

gcaacccuac gaucagguua uuuacucccc gauacgaaag cuuacggcga cagaaucgaa     2220

agaaugcuaa gacuaagucu caauaucgac ccagaugcaa aaguugaaga agaacccgaa     2280

gaagaaccug aagaaacagc agaagauaca acagaagaca cagaacaaga ugaagaugaa     2340

gagauggaug uaggaacaga cgaagaagag gaaacugcaa aagaaucaac agcagaaaaa     2400

gacgaacuau aa                                                         2412


<210>  7625
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSC70__Homo_sapiens__P11142

<400>  7625

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  7626
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSC70__Homo_sapiens__AAH16179

<400>  7626
auguccaagg gaccugcagu ugguauugau cuuggcacca ccuacucuug uguggguguu       60

uuccagcacg gaaaagucga gauaauugcc aaugaucagg gaaaccgaac cacuccaagc      120

uaugucgccu uuacggacac ugaacgguug aucggugaug ccgcaaagaa ucaaguugca      180

augaacccca ccaacacagu uuuugaugcc aaacgucuga uuggacgcag auuugaugau      240

gcuguugucc agucugauau gaaacauugg cccuuuaugg uggugaauga ugcuggcagg      300

cccaaggucc aaguagaaua caagggagag accaaaagcu ucuauccaga ggaggugucu      360

ucuaugguuc ugacaaagau gaaggaaauu gcagaagccu accuugggaa gacuguuacc      420

aaugcugugg ucacagugcc agcuuacuuu aaugacucuc agcgucaggc uaccaaagau      480

gcuggaacua uugcuggucu caauguacuu agaauuauua augagccaac ugcugcugcu      540

auugcuuacg gcuuagacaa aaagguugga gcagaaagaa acgugcucau cuuugaccug      600

ggagguggca cuuuugaugu gucaauccuc acuauugagg auggaaucuu ugaggucaag      660

ucuacagcug gagacaccca cuugggugga gaagauuuug acaaccgaau ggucaaccau      720

uuuauugcug aguuuaagcg caagcauaag aaggacauca gugagaacaa gagagcugua      780

agacgccucc guacugcuug ugaacgugcu aagcguaccc ucucuuccag cacccaggcc      840

aguauugaga ucgauucucu cuaugaagga aucgacuucu auaccuccau uacccgugcc      900

cgauuugaag aacugaaugc ugaccuguuc cguggcaccc uggacccagu agagaaagcc      960

cuucgagaug ccaaacuaga caagucacag auucaugaua uuguccuggu uggugguucu     1020

acucguaucc ccaagauuca gaagcuucuc caagacuucu ucaauggaaa agaacugaau     1080

aagagcauca acccugauga agcuguugcu uauggugcag cuguccaggc agccaucuug     1140

ucuggagaca agucugagaa uguucaagau uugcugcucu uggaugucac uccucuuucc     1200

cuugguauug aaacugcugg uggagucaug acuguccuca ucaagcguaa uaccaccauu     1260

ccuaccaagc agacacagac cuucacuacc uauucugaca accagccugg ugugcuuauu     1320

cagguuuaug aaggcgagcg ugccaugaca aaggauaaca accugcuugg caaguuugaa     1380

cucacaggca uaccuccugc accccgaggu guuccucaga uugaagucac uuuugacauu     1440

gaugccaaug guauacucaa ugucucugcu guggacaaga guacgggaaa agagaacaag     1500

auuacuauca cuaaugacaa gggccguuug agcaaggaag acauugaacg uaugguccag     1560

gaagcugaga aguacaaagc ugaagaugag aagcagaggg acaagguguc auccaagaau     1620

ucacuugagu ccuaugccuu caacaugaaa gcaacuguug aagaugagaa acuucaaggc     1680

aagauuaacg augaggacaa acagaagauu cuggacaagu guaaugaaau uaucaacugg     1740

cuugauaaga aucagacugc cgagaaggaa gaauuugaac aucaacagaa agagcuggag     1800

aaaguuugca accccaucau caccaagcug uaccagagug caggaggcau gccaggagga     1860

augccugggg gauuuccugg ugguggagcu ccucccucug guggugcuuc cucagggccc     1920

accauugaag agguugauua a                                               1941


<210>  7627
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSC70__Homo_sapiens__AAH16179

<400>  7627
augagcaagg gccccgccgu ggggaucgac cugggcacca ccuacuccug cgucggggug       60

uuccagcacg gcaaggugga gaucaucgcc aacgaccagg ggaaccgcac gacccccagc      120

uacgucgcgu ucaccgacac cgagcggcuc aucggcgacg ccgccaagaa ccagguggcc      180

augaacccca cgaacaccgu guucgacgcc aagcgccuga ucggccggcg cuucgacgac      240

gcggucgugc aguccgacau gaagcacugg cccuucaugg uggucaacga cgccgggcgg      300

cccaaggucc agguggagua caagggcgag accaagagcu ucuacccgga ggaggugucc      360

agcauggugc ugaccaagau gaaggagauc gccgaggccu accucgggaa gacggugacc      420

aacgcggucg ugaccgugcc cgccuacuuc aacgacuccc agcgccaggc caccaaggac      480

gccggcacga ucgccgggcu gaacguccug cggaucauca acgagcccac cgcggccgcc      540

aucgccuacg gccucgacaa gaaggugggc gccgagcgca acgugcugau cuucgaccuc      600

gggggcggga ccuucgacgu cagcauccug accaucgagg acggcaucuu cgaggugaag      660

uccacggcgg gcgacaccca ccucgggggc gaggacuucg acaaccggau ggugaaccac      720

uucaucgccg aguucaagcg caagcacaag aaggacauca gcgagaacaa gcgggccguc      780

cgccggcugc gcaccgccug cgagcgggcc aagcgcaccc uguccagcuc cacgcaggcg      840

agcaucgaga ucgacucccu guacgagggg aucgacuucu acaccagcau cacccgggcc      900

cgcuucgagg agcugaacgc cgaccucuuc cggggcaccc uggaccccgu ggagaaggcc      960

cugcgcgacg ccaagcucga caagucccag auccacgaca ucguccuggu cgggggcagc     1020

acgcggaucc cgaagaucca gaagcugcuc caggacuucu ucaacggcaa ggagcugaac     1080

aaguccauca accccgacga ggcgguggcc uacggggccg ccgugcaggc ggccauccug     1140

agcggcgaca agagcgagaa cgugcaggac cuccugcugc ucgacgugac gccccugucc     1200

cuggggaucg agaccgccgg cggggucaug accgugcuca ucaagcgcaa caccaccauc     1260

cccaccaagc agacccagac guucaccacc uacagcgaca accagccggg cgugcugauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accugcucgg gaaguucgag     1380

cugacgggca ucccgcccgc gccccgcggg gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgucuccgcc guggacaaga gcaccgggaa ggagaacaag     1500

aucaccauca ccaacgacaa gggccggcuc uccaaggagg acaucgagcg gauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag aagcagcgcg acaaggucag cuccaagaac     1620

agccuggagu ccuacgccuu caacaugaag gcgacggugg aggacgagaa gcugcagggc     1680

aagaucaacg acgaggacaa gcagaagauc cucgacaagu gcaacgagau caucaacugg     1740

cuggacaaga accagaccgc cgagaaggag gaguucgagc accagcagaa ggagcuggag     1800

aaggugugca accccaucau caccaagcuc uaccagagcg ccgggggcau gcccgggggc     1860

augcccggcg gguucccggg cgggggcgcc ccgcccuccg ggggcgccag cuccggcccc     1920

accaucgagg aggucgacug a                                               1941


<210>  7628
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSC70__Homo_sapiens__AAH16179

<400>  7628
auguccaagg gccccgccgu cggcaucgac cucggcacca ccuacuccug cgucggcguc       60

uuccagcacg gcaaggucga gaucaucgcc aacgaccagg gcaaccgcac cacccccucc      120

uacgucgccu ucaccgacac cgagcgccuc aucggcgacg ccgccaagaa ccaggucgcc      180

augaacccca ccaacaccgu cuucgacgcc aagcgccuca ucggccgccg cuucgacgac      240

gccgucgucc aguccgacau gaagcacugg cccuucaugg ucgucaacga cgccggccgc      300

cccaaggucc aggucgagua caagggcgag accaaguccu ucuaccccga ggaggucucc      360

uccauggucc ucaccaagau gaaggagauc gccgaggccu accucggcaa gaccgucacc      420

aacgccgucg ucaccguccc cgccuacuuc aacgacuccc agcgccaggc caccaaggac      480

gccggcacca ucgccggccu caacguccuc cgcaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccucgacaa gaaggucggc gccgagcgca acguccucau cuucgaccuc      600

ggcggcggca ccuucgacgu cuccauccuc accaucgagg acggcaucuu cgaggucaag      660

uccaccgccg gcgacaccca ccucggcggc gaggacuucg acaaccgcau ggucaaccac      720

uucaucgccg aguucaagcg caagcacaag aaggacaucu ccgagaacaa gcgcgccguc      780

cgccgccucc gcaccgccug cgagcgcgcc aagcgcaccc ucuccuccuc cacccaggcc      840

uccaucgaga ucgacucccu cuacgagggc aucgacuucu acaccuccau cacccgcgcc      900

cgcuucgagg agcucaacgc cgaccucuuc cgcggcaccc ucgaccccgu cgagaaggcc      960

cuccgcgacg ccaagcucga caagucccag auccacgaca ucguccucgu cggcggcucc     1020

acccgcaucc ccaagaucca gaagcuccuc caggacuucu ucaacggcaa ggagcucaac     1080

aaguccauca accccgacga ggccgucgcc uacggcgccg ccguccaggc cgccauccuc     1140

uccggcgaca aguccgagaa cguccaggac cuccuccucc ucgacgucac cccccucucc     1200

cucggcaucg agaccgccgg cggcgucaug accguccuca ucaagcgcaa caccaccauc     1260

cccaccaagc agacccagac cuucaccacc uacuccgaca accagcccgg cguccucauc     1320

caggucuacg agggcgagcg cgccaugacc aaggacaaca accuccucgg caaguucgag     1380

cucaccggca ucccccccgc cccccgcggc gucccccaga ucgaggucac cuucgacauc     1440

gacgccaacg gcauccucaa cgucuccgcc gucgacaagu ccaccggcaa ggagaacaag     1500

aucaccauca ccaacgacaa gggccgccuc uccaaggagg acaucgagcg caugguccag     1560

gaggccgaga aguacaaggc cgaggacgag aagcagcgcg acaaggucuc cuccaagaac     1620

ucccucgagu ccuacgccuu caacaugaag gccaccgucg aggacgagaa gcuccagggc     1680

aagaucaacg acgaggacaa gcagaagauc cucgacaagu gcaacgagau caucaacugg     1740

cucgacaaga accagaccgc cgagaaggag gaguucgagc accagcagaa ggagcucgag     1800

aaggucugca accccaucau caccaagcuc uaccaguccg ccggcggcau gcccggcggc     1860

augcccggcg gcuuccccgg cggcggcgcc ccccccuccg gcggcgccuc cuccggcccc     1920

accaucgagg aggucgacug a                                               1941


<210>  7629
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSC70__Homo_sapiens__AAH16179

<400>  7629
augagcaagg gccccgccgu ggggaucgac cugggaacca cauacuccug cgucgguguu       60

uuccagcacg gcaaagugga gauuauagcu aacgaucaag ggaauagaac uacgccuucu      120

uauguagcau uuaccgacac agaaaggcuc aucggagaug ccgcgaagaa ccagguggcu      180

augaauccaa cuaacaccgu cuucgacgcc aaacggcuua uuggccgccg auuugaugac      240

gcagugguuc agucagauau gaagcauugg ccguucaugg uggucaauga cgccggucgu      300

cccaaagugc agguagagua caagggggaa acaaagaguu uuuauccuga ggaaguuagc      360

uccauggugc ugaccaaaau gaaggagauc gcugaggcau acuugggaaa aacugucaca      420

aacgccgugg ugaccguccc agcuuauuuc aaugauucuc aaagacaggc cacgaaggac      480

gcgggcacua uugcaggcuu aaacguucug aggaucauaa augaacccac cgccgcugcc      540

aucgcauacg ggcuagauaa aaagguggga gcugagcgga acguacucau uuuugaccug      600

gguggcggga cauucgaugu gucgauccuu acuauugaag acggaaucuu ugaggucaag      660

ucaaccgccg gcgacacaca ccuggguggg gaggauuucg acaaucgcau ggugaaccau      720

uuuauagcgg aauuuaaaag aaagcacaaa aaggauauua gcgagaauaa aagggccguu      780

cggcgcuugc gaaccgcaug ugaaagagcu aagaggacgc ucaguuccuc uacucaggcc      840

agcaucgaga uugacucccu guaugaagga aucgauuuuu acacaucaau cacccgggcu      900

cguuucgagg agcugaacgc cgaccucuuc cgcggcacuu uagauccugu ggaaaaagca      960

cugagagacg ccaaacuuga uaagagucag auucaugaca uagucuuggu gggcgggagc     1020

acaaggaucc caaagauuca aaagcugcua caggauuucu ucaauggaaa agagcucaac     1080

aagucuauca accccgacga agcuguagcg uacggugcag ccguucaggc ugccauacug     1140

uccggcgaca aaucagagaa ugugcaggau cuucuguugc ucgacgucac cccucugagc     1200

uuagggauug aaacggcagg aggcgugaug accguccuga ucaagcggaa cacaacuauc     1260

ccaaccaagc aaacacagac uuuuaccaca uauagugaua aucagccggg ugugcucauu     1320

caaguuuacg agggggagcg agccaugacc aaagacaaca aucuucuggg caaguucgaa     1380

uugacuggaa ucccucccgc uccacgcggc gugccccaga uugagguaac guuugauaua     1440

gacgccaacg ggauccuaaa ugucucugca guggauaaau ccacaggaaa ggaaaacaaa     1500

auuaccauca cuaaugacaa ggguagacug agcaaggagg auaucgaaag gaugguucag     1560

gaggcggaga aauauaaggc ugaagacgag aaacagcggg auaagguguc gucuaaaaac     1620

ucccucgaau cauacgccuu caauaugaag gcaaccgucg aggacgagaa gcugcaaggc     1680

aaaauuaacg augaagacaa gcagaaaaua cuugacaagu gcaaugagau cauuaacugg     1740

cuggauaaaa aucagacagc cgaaaaggag gaauuugagc accagcaaaa agaguuggaa     1800

aaggugugua acccuaucau uaccaagcuc uaucagagug cugggggaau gccaggcggu     1860

augcccgggg gcuucccggg aggcggggcc ccucccagcg gaggugcauc cucuggccca     1920

acuaucgagg aaguagacug a                                               1941


<210>  7630
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSC70__Homo_sapiens__AAH16179

<400>  7630
augagcaagg gccccgccgu gggcaucgac cugggcacca ccuacagcug cgugggcgug       60

uuccagcacg gcaaggugga gaucaucgcc aacgaccagg gcaacagaac cacccccagc      120

uacguggccu ucaccgacac cgagagacug aucggcgacg ccgccaagaa ccagguggcc      180

augaacccca ccaacaccgu guucgacgcc aagagacuga ucggcagaag auucgacgac      240

gccguggugc agagcgacau gaagcacugg cccuucaugg uggugaacga cgccggcaga      300

cccaaggugc agguggagua caagggcgag accaagagcu ucuaccccga ggaggugagc      360

agcauggugc ugaccaagau gaaggagauc gccgaggccu accugggcaa gaccgugacc      420

aacgccgugg ugaccgugcc cgccuacuuc aacgacagcc agagacaggc caccaaggac      480

gccggcacca ucgccggccu gaacgugcug agaaucauca acgagcccac cgccgccgcc      540

aucgccuacg gccuggacaa gaaggugggc gccgagagaa acgugcugau cuucgaccug      600

ggcggcggca ccuucgacgu gagcauccug accaucgagg acggcaucuu cgaggugaag      660

agcaccgccg gcgacaccca ccugggcggc gaggacuucg acaacagaau ggugaaccac      720

uucaucgccg aguucaagag aaagcacaag aaggacauca gcgagaacaa gagagccgug      780

agaagacuga gaaccgccug cgagagagcc aagagaaccc ugagcagcag cacccaggcc      840

agcaucgaga ucgacagccu guacgagggc aucgacuucu acaccagcau caccagagcc      900

agauucgagg agcugaacgc cgaccuguuc agaggcaccc uggaccccgu ggagaaggcc      960

cugagagacg ccaagcugga caagagccag auccacgaca ucgugcuggu gggcggcagc     1020

accagaaucc ccaagaucca gaagcugcug caggacuucu ucaacggcaa ggagcugaac     1080

aagagcauca accccgacga ggccguggcc uacggcgccg ccgugcaggc cgccauccug     1140

agcggcgaca agagcgagaa cgugcaggac cugcugcugc uggacgugac cccccugagc     1200

cugggcaucg agaccgccgg cggcgugaug accgugcuga ucaagagaaa caccaccauc     1260

cccaccaagc agacccagac cuucaccacc uacagcgaca accagcccgg cgugcugauc     1320

cagguguacg agggcgagag agccaugacc aaggacaaca accugcuggg caaguucgag     1380

cugaccggca ucccccccgc ccccagaggc gugccccaga ucgaggugac cuucgacauc     1440

gacgccaacg gcauccugaa cgugagcgcc guggacaaga gcaccggcaa ggagaacaag     1500

aucaccauca ccaacgacaa gggcagacug agcaaggagg acaucgagag aauggugcag     1560

gaggccgaga aguacaaggc cgaggacgag aagcagagag acaaggugag cagcaagaac     1620

agccuggaga gcuacgccuu caacaugaag gccaccgugg aggacgagaa gcugcagggc     1680

aagaucaacg acgaggacaa gcagaagauc cuggacaagu gcaacgagau caucaacugg     1740

cuggacaaga accagaccgc cgagaaggag gaguucgagc accagcagaa ggagcuggag     1800

aaggugugca accccaucau caccaagcug uaccagagcg ccggcggcau gcccggcggc     1860

augcccggcg gcuuccccgg cggcggcgcc ccccccagcg gcggcgccag cagcggcccc     1920

accaucgagg agguggacug a                                               1941


<210>  7631
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSC70__Homo_sapiens__AAH16179

<400>  7631
augagcaagg gccccgccgu ggggaucgac cugggaacca cauacuccug cgucggcguu       60

uuccagcacg ggaaagugga gauuaucgcu aacgaucaag gaaauagaac gaccccuucu      120

uauguggccu uuacagacac cgaacggcuc auuggcgaug cggcuaagaa ccaggucgcc      180

augaauccga caaacaccgu guucgacgcc aaacgccuga ucgggagacg guuugaugac      240

gcuguugugc agagcgauau gaagcauugg cccuucaugg ucgugaauga cgccggacgc      300

ccuaaaguuc agguggagua caagggcgaa acaaaguccu uuuaucccga ggaagucucu      360

agcauggugc uuaccaaaau gaaggagauu gcugaggccu accugggcaa aacggugacc      420

aacgcggucg uuacagugcc ugccuauuuc aaugauuccc aaagacaggc uaccaaggac      480

gccgggacaa ucgcuggacu caacgugcug cggaucauua augaacccac cgccgcggcc      540

aucgcuuacg gccuugauaa aaaggucggg gccgagcgca acgugcugau uuuugaccuc      600

ggaggcggga cguucgaugu uucuauccug acaauugaag acggaaucuu ugaggugaag      660

ucuaccgcug gcgacacaca ccugggcggg gaggauuucg acaauagaau ggucaaccau      720

uuuauugccg aauuuaaacg gaagcacaaa aaggauaucu ccgagaauaa acgcgccgug      780

agacggcucc gcaccgcuug ugaaagagcg aagcggaccc ugagcagcuc cacacaggcc      840

agcaucgaga uugacucucu uuaugaagga aucgauuuuu acacguccau uacccgcgcu      900

agauucgagg agcugaacgc cgaccucuuc cggggcacac uggauccugu ugaaaaagcc      960

cuuagagacg cuaagcugga uaagagccag auccaugaca uugugcucgu cgggggaucu     1020

acccgcaucc cgaaaaucca aaagcugcug caggauuucu ucaauggcaa agagcucaac     1080

aaguccauua accccgacga agccguggcg uacggggcug ccguccaggc cgcuauccug     1140

agcggagaca aauccgagaa ugugcaggau cuucugcucc uggacguuac accucuuucu     1200

cugggcauug aaaccgccgg cggggugaug acgguccuca ucaagcggaa cacaaccauu     1260

cccaccaagc aaacacagac cuuuacaacg uauagcgaua aucagccugg agugcugauc     1320

caaguuuacg agggcgagag agcuaugacc aaagacaaca aucugcucgg gaaguucgaa     1380

cugacaggaa ucccgcccgc cccucgcggc gugccccaga uugaggucac cuuugauauc     1440

gacgcgaacg ggauucuuaa uguguccgcc guggauaaaa gcacaggcaa ggaaaacaaa     1500

aucaccauua cgaaugacaa gggacggcug ucuaaggagg auaucgaaag aaugguucag     1560

gaggcugaga aauauaaggc cgaagacgag aaacagcgcg auaaggucuc cagcaaaaac     1620

ucucucgaaa gcuacgcuuu caauaugaag gccaccgugg aggacgagaa gcugcaaggc     1680

aaaauuaacg augaagacaa gcagaaaauc cuugacaagu gcaaugagau cauuaacugg     1740

cuggauaaaa aucagacagc ggaaaaggag gaauuugagc accagcaaaa agagcucgaa     1800

aaggugugua acccuaucau uaccaagcug uaucaguccg ccgggggaau gcccggcggg     1860

augcccggag gcuucccugg gggcggagcu ccgcccucug gcggggccag cuccggaccu     1920

acaaucgagg aagucgacug a                                               1941


<210>  7632
<211>  1941
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSC70__Homo_sapiens__AAH16179

<400>  7632
augucuaagg gucccgcagu ugggauugau uuaggaacua cuuauucaug cguaggagua       60

uuccaacacg gaaaaguaga aauuauagca aacgaccaag gaaaucgaac aacaccaagu      120

uaugucgccu uuacugauac ugaaagacuc auaggagacg cugcaaaaaa ccaaguugca      180

augaacccaa cuaauacagu auucgaugca aaaagacuaa uagguagaag auucgacgac      240

gcuguaguac aaagugauau gaaacacugg ccauuuaugg uagugaauga cgccgguaga      300

ccaaaaguac aaguagaaua uaaaggugaa accaaaaguu uuuacccaga agaaguaagc      360

ucaaugguau uaaccaaaau gaaagagaua gcagaagcgu auuuaggaaa aacaguaacu      420

aacgcaguag ucaccguacc agcauacuuu aaugauucuc aaagacaagc aacaaaagau      480

gcaggaacaa ucgccggauu aaauguacua agaaucauaa augaaccuac agcagcagca      540

auagcauacg gauuagauaa aaaaguaggc gcagaaagaa auguacuaau auuugaccuc      600

ggaggaggaa cauuugacgu uucaauuuua accauagaag acggaauuuu cgaaguaaaa      660

ucaacagcag gagacacuca ucuagguggc gaagauuuug acaaucgaau gguaaaccau      720

uucauugcag aauuuaaaag aaaacauaaa aaggauauau cagaaaacaa aagagcaguc      780

agaagguuaa gaacagcaug ugaaagagca aaaagaacau uaucuucaag uacgcaagca      840

aguauagaaa ucgacaguuu auaugaagga auugauuuuu acacaucaau cacacgagcu      900

agguuugaag aacuaaaugc agaccucuuc agaggaacau uggauccagu agagaaagcu      960

cuacgagaug cuaaacuaga caaaucacaa auacaugaca uagugcuggu aggcggauca     1020

acaagaaucc cgaaaauaca aaaauuacua caagauuucu uuaauggaaa agaacuuaac     1080

aaaucaauaa auccagacga agcuguagca uacggugcag cagugcaagc agcaauuuua     1140

uccggagaca aaucagaaaa cgugcaagau uuauuacuac uagacguuac accacuaagu     1200

cuagguauag aaacagcggg aggaguaaug acaguauuaa uaaaacgaaa uaccacaaua     1260

cccacuaaac aaacgcaaac auuuacaaca uauucagaca aucaaccugg cgugcugauc     1320

caaguauacg aaggagaaag agcaaugaca aaagauaaca accuuuuagg caaauuugaa     1380

cuaacaggua uaccaccugc accaagggga guaccacaaa ucgaaguuac auucgacaua     1440

gacgcaaacg gaauauuaaa uguaagugca guagacaaau caacagguaa agaaaacaag     1500

auaacuauaa caaacgauaa aggaagacua ucuaaagaag acauagaacg aaugguacaa     1560

gaagcagaaa aauacaaagc cgaggacgaa aaacaaagag auaaaguaag uagcaaaaau     1620

aguuuagaau cauacgcauu caauaugaaa gcaacugugg aggacgaaaa auugcaagga     1680

aaaauaaaug augaagacaa acaaaagaua uuagauaaau guaaugaaau aauaaacugg     1740

cuagauaaaa aucaaacagc agaaaaagaa gaauuugaac aucaacaaaa agaauuggaa     1800

aaaguaugca auccaauaau aacaaaacua uaucaaagcg cagggggcau gcccggcgga     1860

augcccggag gcuuuccagg aggaggagcu ccaccaucag guggcgcuuc aagugguccc     1920

acaauagaag aaguagauua a                                               1941


<210>  7633
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP110__Homo_sapiens__Q92598

<400>  7633

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
        35                  40                  45              


Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
    50                  55                  60                  


Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
65                  70                  75                  80  


Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                85                  90                  95      


Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
            100                 105                 110         


Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
145                 150                 155                 160 


Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                165                 170                 175     


Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
        195                 200                 205             


Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
    210                 215                 220                 


Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
225                 230                 235                 240 


Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
    290                 295                 300                 


Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
305                 310                 315                 320 


Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
385                 390                 395                 400 


Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                405                 410                 415     


His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
        435                 440                 445             


Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
    450                 455                 460                 


Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                485                 490                 495     


Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
            500                 505                 510         


Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
        515                 520                 525             


Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
    530                 535                 540                 


Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                565                 570                 575     


Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
            580                 585                 590         


Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
        595                 600                 605             


Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
    610                 615                 620                 


Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
625                 630                 635                 640 


Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                645                 650                 655     


Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
            660                 665                 670         


Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
        675                 680                 685             


Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
    690                 695                 700                 


Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
705                 710                 715                 720 


Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                725                 730                 735     


Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
            740                 745                 750         


Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
        755                 760                 765             


Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
    770                 775                 780                 


Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
785                 790                 795                 800 


Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                805                 810                 815     


Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
            820                 825                 830         


Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
        835                 840                 845             


Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
    850                 855             


<210>  7634
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP110__Homo_sapiens__AAH37553

<400>  7634
augucggugg ugggguugga cgugggcucg cagagcugcu acaucgcggu agcccgggcc       60

gggggcaucg agaccaucgc caaugaguuc agcgaccggu gcaccccguc agucauauca      120

uuuggaucaa aaaauagaac aaucggaguu gcagccaaaa aucagcaaau cacucaugca      180

aacaauacgg ugucuaacuu caaaagauuu cauggccgag cauucaauga ccccuucauu      240

caaaaggaga aggaaaacuu gaguuacgau uugguuccau ugaaaaaugg uggaguugga      300

auaaagguaa uguacauggg ugaagaacau cuauuuagug uggagcagau aacagccaug      360

uuguugacua agcugaagga aacugcugaa aacagccuca agaaaccagu aacagauugu      420

guuauuucag uccccuccuu cuuuacagau gcugagaggc gaucuguguu agaugcugca      480

cagauuguug gccuaaacug uuuaagacuu augaaugaca ugacagcugu ugcuuugaau      540

uacggaauuu auaagcagga ucucccaagc cuggaugaga aaccucggau agugguuuuu      600

guugauaugg gacauucagc uuuucaagug ucugcuugug cuuuuaacaa gggaaaauug      660

aagguacugg gaacagcuuu ugauccuuuc uuaggaggaa aaaacuucga ugaaaaguua      720

guggaacauu uuugugcaga auuuaaaacu aaguacaagu uggaugcaaa auccaaaaua      780

cgagcacucc uacgucugua ucaggaaugu gaaaaacuga aaaagcuaau gagcucuaac      840

agcacagacc uuccacugaa uaucgaaugc uuuaugaaug auaaagaugu uuccggaaag      900

augaacaggu cacaauuuga agaacucugu gcugaacuuc ugcaaaagau agaaguaccc      960

cuuuauucac uguuggaaca aacucaucuc aaaguagaag augugagugc aguugagauu     1020

guuggaggcg cuacacgaau uccagcugug aaggaaagaa uugccaaauu cuuuggaaaa     1080

gauauuagca caacacucaa ugcagaugaa gcaguagcca gaggaugugc auuacagugu     1140

gcaauacuuu ccccggcauu uaaaguuaga gaauuuuccg ucacagaugc aguuccuuuu     1200

ccaauaucuc ugaucuggaa ccaugauuca gaagauacug aagguguuca ugaagucuuu     1260

agucgaaacc augcugcucc uuucuccaaa guucucaccu uucugagaag ggggccuuuu     1320

gagcuagaag cuuucuauuc ugauccccaa ggaguuccau auccagaagc aaaaauaggc     1380

cgcuuuguag uucagaaugu uucugcacag aaagauggag aaaaaucuag aguaaaaguc     1440

aaagugcgag ucaacaccca uggcauuuuc accaucucua cggcaucuau gguggagaaa     1500

gucccaacug aggagaauga aaugucuucu gaagcugaca uggagugucu gaaucagaga     1560

ccaccagaaa acccagacac ugauaaaaau guccagcaag acaacaguga agcuggaaca     1620

cagccccagg uacaaacuga ugcucaacaa accucacagu cucccccuuc accugaacuu     1680

accucagaag aaaacaaaau cccagaugcu gacaaagcaa augaaaaaaa aguugaccag     1740

ccuccagaag cuaaaaagcc caaaauaaag guggugaaug uugagcugcc uauugaagcc     1800

aacuuggucu ggcaguuagg gaaagaccuu cuuaacaugu auauugagac agaggguaag     1860

augauaaugc aagauaaauu ggaaaaagaa aggaaugaug cuaaaaaugc aguugaggaa     1920

uauguguaug aguucagaga caagcugugu ggaccauaug aaaaauuuau augugagcag     1980

gaucaucaaa auuuuuugag acuccucaca gaaacugaag acuggcugua ugaagaagga     2040

gaggaccaag cuaaacaagc auauguugac aaguuggaag aauuaaugaa aauuggcacu     2100

ccaguuaaag uucgguuuca ggaagcugaa gaacggccaa aaauguuuga agaacuagga     2160

cagaggcugc agcauuaugc caagauagca gcugacuuca gaaauaagga ugagaaauac     2220

aaccauauug augagucuga aaugaaaaaa guggagaagu cuguuaauga agugauggaa     2280

uggaugaaua augucaugaa ugcucaggcu aaaaagaguc uugaucagga uccaguugua     2340

cgugcucagg aaauuaaaac aaaaaucaag gaauugaaca acacauguga acccguugua     2400

acacaaccga aaccaaaaau ugaaucaccc aaacuggaaa gaacuccaaa uggcccaaau     2460

auugauaaaa aggaagaaga uuuagaagac aaaaacaauu uuggugcuga accuccacau     2520

cagaauggug aauguuaccc uaaugagaaa aauucuguua auauggacuu ggacuag        2577


<210>  7635
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP110__Homo_sapiens__AAH37553

<400>  7635
augagcgugg ucggccugga cguggggucc cagagcugcu acaucgccgu ggcccgcgcg       60

ggcgggaucg agaccaucgc caacgaguuc uccgaccggu gcacccccag cgucaucucc      120

uucggcagca agaaccgcac caucggggug gccgccaaga accagcagau cacccacgcc      180

aacaacaccg uguccaacuu caagcgguuc cacggccgcg cguucaacga cccguucauc      240

cagaaggaga aggagaaccu cagcuacgac cugguccccc ugaagaacgg cggggugggc      300

aucaagguga uguacauggg ggaggagcac cucuucuccg ucgagcagau caccgccaug      360

cugcugacga agcucaagga gaccgccgag aacagccuga agaagcccgu gaccgacugc      420

gugaucuccg uccccagcuu cuucaccgac gccgagcggc gcuccgugcu ggacgcggcc      480

cagaucgugg gccucaacug ccugcggcug augaacgaca ugacggccgu cgcccucaac      540

uacgggaucu acaagcagga ccugccgagc cuggacgaga agccccgcau cgugguguuc      600

gucgacaugg gccacuccgc cuuccaggug agcgcgugcg ccuucaacaa gggcaagcuc      660

aaggugcugg ggaccgccuu cgaccccuuc cugggcggga agaacuucga cgagaagcuc      720

gucgagcacu ucugcgccga guucaagacc aaguacaagc uggacgccaa guccaagauc      780

cgggcgcugc uccgccugua ccaggagugc gagaagcuga agaagcucau gagcuccaac      840

agcaccgacc ugccccugaa caucgagugc uucaugaacg acaaggacgu gagcggcaag      900

augaaccggu cccaguucga ggagcucugc gccgagcugc ugcagaagau cgaggugccg      960

cucuacagcc ugcuggagca gacgcaccuc aaggucgagg acguguccgc cgucgagauc     1020

gugggcgggg ccacccgcau ccccgccgug aaggagcgga ucgcgaaguu cuucggcaag     1080

gacaucagca ccacccugaa cgccgacgag gccgucgccc gcgggugcgc ccugcagugc     1140

gcgauccucu cccccgccuu caaggugcgg gaguucagcg ugacggacgc cguccccuuc     1200

ccgaucuccc ugaucuggaa ccacgacagc gaggacaccg agggcgugca cgagguguuc     1260

ucccgcaacc acgccgcgcc cuucagcaag guccugaccu uccuccggcg cgggcccuuc     1320

gagcuggagg ccuucuacuc cgacccccag ggcgugccgu accccgaggc caagaucggc     1380

cgguucgugg uccagaacgu gagcgcccag aaggacgggg agaagucccg cgugaagguc     1440

aaggugcggg ugaacaccca cggcaucuuc acgaucagca ccgccuccau ggucgagaag     1500

gugcccaccg aggagaacga gaugagcucc gaggcggaca uggagugccu gaaccagcgg     1560

cccccggaga accccgacac cgacaagaac gugcagcagg acaacagcga ggccgggacg     1620

cagccccagg uccagaccga cgcccagcag accucccaga gcccgcccag ccccgagcuc     1680

accuccgagg agaacaagau ccccgacgcc gacaaggcca acgagaagaa gguggaccag     1740

cccccggagg cgaagaagcc caagaucaag guggucaacg uggagcugcc caucgaggcc     1800

aaccuggugu ggcagcucgg caaggaccug cugaacaugu acaucgagac ggaggggaag     1860

augaucaugc aggacaagcu cgagaaggag cgcaacgacg ccaagaacgc cgucgaggag     1920

uacguguacg aguuccgcga caagcugugc ggcccguacg agaaguucau cugcgagcag     1980

gaccaccaga acuuccugcg ccugcucacc gagaccgagg acuggcugua cgaggagggc     2040

gaggaccagg ccaagcaggc guacguggac aagcuggagg agcucaugaa gaucgggacc     2100

cccgucaagg ugcgguucca ggaggccgag gagcgcccca agauguucga ggagcugggc     2160

cagcggcugc agcacuacgc caagaucgcc gcggacuucc gcaacaagga cgagaaguac     2220

aaccacaucg acgagagcga gaugaagaag guggagaagu ccgucaacga ggugauggag     2280

uggaugaaca acgugaugaa cgcccaggcc aagaaguccc ucgaccagga ccccgucgug     2340

cgggcccagg agaucaagac gaagaucaag gagcugaaca acacgugcga gccggugguc     2400

acccagccca agcccaagau cgagagcccc aagcuggagc gcaccccgaa cgggcccaac     2460

aucgacaaga aggaggagga ccucgaggac aagaacaacu ucggcgccga gccgccccac     2520

cagaacgggg agugcuaccc caacgagaag aacagcguga acauggaccu ggacuga        2577


<210>  7636
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP110__Homo_sapiens__AAH37553

<400>  7636
auguccgucg ucggccucga cgucggcucc caguccugcu acaucgccgu cgcccgcgcc       60

ggcggcaucg agaccaucgc caacgaguuc uccgaccgcu gcacccccuc cgucaucucc      120

uucggcucca agaaccgcac caucggcguc gccgccaaga accagcagau cacccacgcc      180

aacaacaccg ucuccaacuu caagcgcuuc cacggccgcg ccuucaacga ccccuucauc      240

cagaaggaga aggagaaccu cuccuacgac cucguccccc ucaagaacgg cggcgucggc      300

aucaagguca uguacauggg cgaggagcac cucuucuccg ucgagcagau caccgccaug      360

cuccucacca agcucaagga gaccgccgag aacucccuca agaagcccgu caccgacugc      420

gucaucuccg uccccuccuu cuucaccgac gccgagcgcc gcuccguccu cgacgccgcc      480

cagaucgucg gccucaacug ccuccgccuc augaacgaca ugaccgccgu cgcccucaac      540

uacggcaucu acaagcagga ccuccccucc cucgacgaga agccccgcau cgucgucuuc      600

gucgacaugg gccacuccgc cuuccagguc uccgccugcg ccuucaacaa gggcaagcuc      660

aagguccucg gcaccgccuu cgaccccuuc cucggcggca agaacuucga cgagaagcuc      720

gucgagcacu ucugcgccga guucaagacc aaguacaagc ucgacgccaa guccaagauc      780

cgcgcccucc uccgccucua ccaggagugc gagaagcuca agaagcucau guccuccaac      840

uccaccgacc ucccccucaa caucgagugc uucaugaacg acaaggacgu cuccggcaag      900

augaaccgcu cccaguucga ggagcucugc gccgagcucc uccagaagau cgaggucccc      960

cucuacuccc uccucgagca gacccaccuc aaggucgagg acgucuccgc cgucgagauc     1020

gucggcggcg ccacccgcau ccccgccguc aaggagcgca ucgccaaguu cuucggcaag     1080

gacaucucca ccacccucaa cgccgacgag gccgucgccc gcggcugcgc ccuccagugc     1140

gccauccucu cccccgccuu caagguccgc gaguucuccg ucaccgacgc cguccccuuc     1200

cccaucuccc ucaucuggaa ccacgacucc gaggacaccg agggcgucca cgaggucuuc     1260

ucccgcaacc acgccgcccc cuucuccaag guccucaccu uccuccgccg cggccccuuc     1320

gagcucgagg ccuucuacuc cgacccccag ggcguccccu accccgaggc caagaucggc     1380

cgcuucgucg uccagaacgu cuccgcccag aaggacggcg agaagucccg cgucaagguc     1440

aagguccgcg ucaacaccca cggcaucuuc accaucucca ccgccuccau ggucgagaag     1500

guccccaccg aggagaacga gauguccucc gaggccgaca uggagugccu caaccagcgc     1560

ccccccgaga accccgacac cgacaagaac guccagcagg acaacuccga ggccggcacc     1620

cagccccagg uccagaccga cgcccagcag accucccagu ccccccccuc ccccgagcuc     1680

accuccgagg agaacaagau ccccgacgcc gacaaggcca acgagaagaa ggucgaccag     1740

ccccccgagg ccaagaagcc caagaucaag gucgucaacg ucgagcuccc caucgaggcc     1800

aaccucgucu ggcagcucgg caaggaccuc cucaacaugu acaucgagac cgagggcaag     1860

augaucaugc aggacaagcu cgagaaggag cgcaacgacg ccaagaacgc cgucgaggag     1920

uacgucuacg aguuccgcga caagcucugc ggccccuacg agaaguucau cugcgagcag     1980

gaccaccaga acuuccuccg ccuccucacc gagaccgagg acuggcucua cgaggagggc     2040

gaggaccagg ccaagcaggc cuacgucgac aagcucgagg agcucaugaa gaucggcacc     2100

cccgucaagg uccgcuucca ggaggccgag gagcgcccca agauguucga ggagcucggc     2160

cagcgccucc agcacuacgc caagaucgcc gccgacuucc gcaacaagga cgagaaguac     2220

aaccacaucg acgaguccga gaugaagaag gucgagaagu ccgucaacga ggucauggag     2280

uggaugaaca acgucaugaa cgcccaggcc aagaaguccc ucgaccagga ccccgucguc     2340

cgcgcccagg agaucaagac caagaucaag gagcucaaca acaccugcga gcccgucguc     2400

acccagccca agcccaagau cgaguccccc aagcucgagc gcacccccaa cggccccaac     2460

aucgacaaga aggaggagga ccucgaggac aagaacaacu ucggcgccga gcccccccac     2520

cagaacggcg agugcuaccc caacgagaag aacuccguca acauggaccu cgacuga        2577


<210>  7637
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP110__Homo_sapiens__AAH37553

<400>  7637
augagcgugg ucggccugga cguugggucc cagucuugcu acaucgccgu ggcuagagca       60

ggagguauug agaccauagc caacgaguuc ucagauaggu guacacccag uguaaucagc      120

uuuggcucca agaaucggac uauuggggug gcggcuaaaa accaacagau cacgcacgcc      180

aauaacaccg ucucuaauuu caagcgcuuu cauggacgag cauucaacga cccuuuuauu      240

cagaaagaga aggaaaaucu cucguaugau cuugugccac ugaaaaacgg cgguguuggg      300

aucaagguga uguacauggg agaggaacac uuguucucag ucgagcagau aacagccaug      360

uuacugacua agcuaaaaga gaccgcugaa aauagccuca agaaaccggu gacagacugc      420

guaaucagug uucccuccuu uuucaccgau gcagagcgua gaucugugcu ggacgccgcu      480

caaauugucg gccuuaacug ucugagguug augaaugaua ugacugccgu ggcgcucaac      540

uauggcaucu acaagcagga ccugccuagc cuggaugaaa aaccacggau uguggucuuu      600

guugacaugg ggcauuccgc auuccaggug ucagccugcg cuuuuaauaa gggaaagcuc      660

aaaguauuag guacagccuu cgaucccuuu cugggcggga agaacuucga cgagaaacuu      720

guggagcacu ucugugcaga auuuaagacc aaauauaagu uggaugcuaa aaguaagauc      780

cgcgcccugc uaagacucua ccaggagugc gaaaagcuga aaaagcugau gagcucuaau      840

uccacggacc uuccuuugaa cauagagugu uucaugaacg acaaagaugu cucaggaaag      900

augaauagga gccaauuuga agaacucugc gcggagcugu uacagaaaau ugaagugcca      960

cuguauaguc uccuugagca gacucaucug aagguugaag acgugucugc cgucgagauc     1020

gugggcggug caacccggau ucccgcugua aaggaacgca ucgccaaauu cuuugggaag     1080

gauaucucca caacuuugaa cgcugacgag gccguugcac gaggaugugc ccuacagugc     1140

gcuauucuga gcccugcguu caaagugaga gaguuuucgg ucaccgaugc agugccauuc     1200

ccgauaucuc ucaucuggaa ucacgacucc gaagauacag agggcgucca cgaaguguuu     1260

ucaaggaacc augccgcucc cuucaguaag guucugaccu uucuucggcg uggcccuuuc     1320

gagcuggaag ccuuuuacag cgacccacaa ggggugcccu acccugaggc aaaaauugga     1380

cgcuucguag uccagaaugu guccgcccag aaggauggug agaagucuag aguuaaagug     1440

aaggucaggg ugaacacgca cggcaucuuc acuauaagca cagcuucaau gguagaaaaa     1500

gugccaaccg aggaaaauga gaugaguucc gaggccgaca uggaauguuu gaaccaacgg     1560

cccccggaga auccugauac ugacaagaac guucagcagg acaauagcga agcagggaca     1620

cagccccaag uccagaccga ugcgcagcag acgucucaau caccaccuag ucccgagcuc     1680

accagcgaag agaacaaaau uccagacgcu gauaaggcca augagaagaa aguggaccag     1740

cccccugaag caaagaaacc aaagaucaaa guggucaacg uugagcugcc gaucgaagcc     1800

aauuuagugu ggcagcuggg aaaggaucua cucaacaugu auauugagac agaaggcaaa     1860

augaucaugc aggacaagcu ggagaaggag cgaaacgaug cuaaaaaugc cguggaagag     1920

uacguauaug aauuucgcga caaacuuugc ggucccuacg agaaauucau uugcgaacaa     1980

gaucaucaga acuuuuugag acugcucacu gagaccgagg acuggcugua ugaagagggg     2040

gaagaucagg caaagcaggc uuacgucgac aaacuugagg agcugaugaa gauaggcaca     2100

ccugugaagg uuagguucca agaagccgag gaacggccaa aaauguuuga ggaauuggga     2160

cagcgccucc agcacuaugc gaagaucgcc gcugauuuca gaaauaaaga cgagaaguac     2220

aaccacauug acgaguccga aaugaaaaag guggagaagu cugucaauga agugauggag     2280

uggaugaaca auguuaugaa cgcacaagcc aaaaagucgc uggaucagga ccccguggua     2340

agggcucagg aaaucaaaac uaagaucaaa gaguuaaaua acaccuguga gccugucgug     2400

acacagccaa agcccaagau ugaaagcccg aaacuggagc guaccccuaa uggcccaaac     2460

auagauaaga aagaagagga ccuagaagau aagaauaacu uuggggccga gcccccucau     2520

caaaauggag agugcuaccc caacgaaaag aacuccguga auauggaccu cgauuga        2577


<210>  7638
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP110__Homo_sapiens__AAH37553

<400>  7638
augagcgugg ugggccugga cgugggcagc cagagcugcu acaucgccgu ggccagagcc       60

ggcggcaucg agaccaucgc caacgaguuc agcgacagau gcacccccag cgugaucagc      120

uucggcagca agaacagaac caucggcgug gccgccaaga accagcagau cacccacgcc      180

aacaacaccg ugagcaacuu caagagauuc cacggcagag ccuucaacga ccccuucauc      240

cagaaggaga aggagaaccu gagcuacgac cuggugcccc ugaagaacgg cggcgugggc      300

aucaagguga uguacauggg cgaggagcac cuguucagcg uggagcagau caccgccaug      360

cugcugacca agcugaagga gaccgccgag aacagccuga agaagcccgu gaccgacugc      420

gugaucagcg ugcccagcuu cuucaccgac gccgagagaa gaagcgugcu ggacgccgcc      480

cagaucgugg gccugaacug ccugagacug augaacgaca ugaccgccgu ggcccugaac      540

uacggcaucu acaagcagga ccugcccagc cuggacgaga agcccagaau cgugguguuc      600

guggacaugg gccacagcgc cuuccaggug agcgccugcg ccuucaacaa gggcaagcug      660

aaggugcugg gcaccgccuu cgaccccuuc cugggcggca agaacuucga cgagaagcug      720

guggagcacu ucugcgccga guucaagacc aaguacaagc uggacgccaa gagcaagauc      780

agagcccugc ugagacugua ccaggagugc gagaagcuga agaagcugau gagcagcaac      840

agcaccgacc ugccccugaa caucgagugc uucaugaacg acaaggacgu gagcggcaag      900

augaacagaa gccaguucga ggagcugugc gccgagcugc ugcagaagau cgaggugccc      960

cuguacagcc ugcuggagca gacccaccug aagguggagg acgugagcgc cguggagauc     1020

gugggcggcg ccaccagaau ccccgccgug aaggagagaa ucgccaaguu cuucggcaag     1080

gacaucagca ccacccugaa cgccgacgag gccguggcca gaggcugcgc ccugcagugc     1140

gccauccuga gccccgccuu caaggugaga gaguucagcg ugaccgacgc cgugcccuuc     1200

cccaucagcc ugaucuggaa ccacgacagc gaggacaccg agggcgugca cgagguguuc     1260

agcagaaacc acgccgcccc cuucagcaag gugcugaccu uccugagaag aggccccuuc     1320

gagcuggagg ccuucuacag cgacccccag ggcgugcccu accccgaggc caagaucggc     1380

agauucgugg ugcagaacgu gagcgcccag aaggacggcg agaagagcag agugaaggug     1440

aaggugagag ugaacaccca cggcaucuuc accaucagca ccgccagcau gguggagaag     1500

gugcccaccg aggagaacga gaugagcagc gaggccgaca uggagugccu gaaccagaga     1560

ccccccgaga accccgacac cgacaagaac gugcagcagg acaacagcga ggccggcacc     1620

cagccccagg ugcagaccga cgcccagcag accagccaga gcccccccag ccccgagcug     1680

accagcgagg agaacaagau ccccgacgcc gacaaggcca acgagaagaa gguggaccag     1740

ccccccgagg ccaagaagcc caagaucaag guggugaacg uggagcugcc caucgaggcc     1800

aaccuggugu ggcagcuggg caaggaccug cugaacaugu acaucgagac cgagggcaag     1860

augaucaugc aggacaagcu ggagaaggag agaaacgacg ccaagaacgc cguggaggag     1920

uacguguacg aguucagaga caagcugugc ggccccuacg agaaguucau cugcgagcag     1980

gaccaccaga acuuccugag acugcugacc gagaccgagg acuggcugua cgaggagggc     2040

gaggaccagg ccaagcaggc cuacguggac aagcuggagg agcugaugaa gaucggcacc     2100

cccgugaagg ugagauucca ggaggccgag gagagaccca agauguucga ggagcugggc     2160

cagagacugc agcacuacgc caagaucgcc gccgacuuca gaaacaagga cgagaaguac     2220

aaccacaucg acgagagcga gaugaagaag guggagaaga gcgugaacga ggugauggag     2280

uggaugaaca acgugaugaa cgcccaggcc aagaagagcc uggaccagga ccccguggug     2340

agagcccagg agaucaagac caagaucaag gagcugaaca acaccugcga gcccguggug     2400

acccagccca agcccaagau cgagagcccc aagcuggaga gaacccccaa cggccccaac     2460

aucgacaaga aggaggagga ccuggaggac aagaacaacu ucggcgccga gcccccccac     2520

cagaacggcg agugcuaccc caacgagaag aacagcguga acauggaccu ggacuga        2577


<210>  7639
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP110__Homo_sapiens__AAH37553

<400>  7639
augagcgugg ucggccugga cguugggucc cagucuugcu acaucgccgu ggcuagagcc       60

ggaggcauug agaccaucgc gaacgaauuu agcgaucggu guacacccuc cgugauuucu      120

uuugggagca agaaucgcac gaucggaguc gcugccaaaa accaacagau uacccacgcc      180

aauaacacag uguccaauuu caagagauuu cauggccggg cuuucaacga cccuuuuauc      240

cagaaagaga aggaaaaucu cucuuaugau cugguuccgc uuaaaaacgg gggagugggc      300

aucaagguca uguacauggg cgaggaacac cuguucagcg uggagcagau uaccgccaug      360

cuccugacaa aacuuaaaga gaccgcugaa aauucccuga agaaacccgu uacagacugc      420

gugaucagcg ucccuucuuu cuucaccgau gccgagcgca gauccgugcu cgacgcggcc      480

caaauugugg ggcugaacug ucugcggcuc augaaugaua ugacggcugu cgcccugaac      540

uauggaaucu acaagcagga ccuucccagc cuggaugaaa aaccucgcau uguuguguuu      600

guggacaugg gccauucugc uuuccagguc uccgccugcg cguuuaauaa ggggaagcuc      660

aaagugcugg gaaccgccuu cgaucccuuu cuuggcggga agaacuucga cgagaaacug      720

guugagcacu ucugugcuga auuuaagaca aaauauaagc ucgaugccaa aagcaagauc      780

agagcucugc ugcggcucua ccaggagugc gaaaagcuga aaaagcugau gucuuccaau      840

agcaccgacc uuccucucaa cauugagugu uucaugaacg acaaagaugu guccggaaag      900

augaaucgcu cucaauuuga ggaacugugc gccgagcuuc ugcagaaaau cgaagucccg      960

cucuauagcc ugcuggagca gacacaucuc aagguggaag acguuuccgc cguggagauc     1020

gucggcggcg cuacccggau ucccgcggug aaggaaagaa ucgccaaauu cuuugggaag     1080

gauauuagca cgacacugaa cgcugacgag gccgucgccc gcggaugugc ccuucagugc     1140

gcuauccugu cuccugcguu caaagugaga gaguuuuccg uuaccgaugc ugugcccuuc     1200

ccuauuagcc ucaucuggaa ucacgacucu gaagauacag agggcgucca cgaaguguuu     1260

agccggaacc augccgcccc cuucuccaag guucugaccu uucuucgcag agggccguuc     1320

gagcuggagg cuuuuuacuc ugacccucaa ggagugcccu acccugaagc caaaaucggc     1380

cgguucgucg ugcagaaugu gagcgcucag aaggaugggg agaaguccag aguuaaaguc     1440

aaggugcgcg ugaacaccca cggaauuuuc acaaucagca cggccucuau ggucgaaaaa     1500

gugcccaccg aggaaaauga gauguccagc gaggcggaca uggaaugucu caaccaacgg     1560

cccccugaga auccggauac agacaagaac guucagcagg acaauucuga agccggcacc     1620

cagccccaag ugcagacaga ugcucagcag accucccaaa gcccucccuc cccugagcug     1680

acgucugaag agaacaaaau ucccgacgcc gauaaggcua augagaagaa agucgaccag     1740

ccgccugaag ccaagaaacc caagaucaaa gugguuaacg uggagcugcc uauugaagcg     1800

aaucucgucu ggcagcuggg caaggaucuu cugaacaugu auaucgagac agaagggaaa     1860

augaucaugc aggacaagcu cgagaaggag agaaacgaug ccaaaaaugc uguggaagag     1920

uacguuuaug aauuucgcga caagcugugc ggacccuacg agaaauucau uugcgaacaa     1980

gaucaucaga acuuucugcg gcuucucacc gagaccgagg acuggcugua ugaagagggc     2040

gaagaucagg ccaagcaggc uuacguggac aaacuggagg agcucaugaa gaucgggaca     2100

ccugucaagg ugagauucca agaagccgag gaacgcccca aaauguuuga ggaacuggga     2160

cagcggcuuc agcacuaugc caagauugcu gcggauuuca gaaauaaaga cgagaaguac     2220

aaccacaucg acgagagcga aaugaaaaag guggagaagu ccgucaauga aguuauggag     2280

uggaugaaca augugaugaa cgcccaagcu aaaaagucuc uggaucagga cccggugguc     2340

cgcgcccagg aaauuaaaac caagaucaaa gagcucaaua acacauguga gccugugguu     2400

acgcagccca agcccaagau ugaaagcccu aaacuggagc ggaccccgaa uggccccaac     2460

aucgauaaga aagaagagga ccuggaagau aagaauaacu uuggggccga gccuccccau     2520

caaaauggcg agugcuaccc uaacgaaaag aacuccguga auauggaccu ugauuga        2577


<210>  7640
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP110__Homo_sapiens__AAH37553

<400>  7640
augucaguug ucggauuaga uguaggaucu caaucauguu acauugcggu cgccagagcu       60

ggcggaauag aaacaauagc gaacgaauuc ucagacagau guacaccauc aguuauaagu      120

uuugguagca aaaacagaac aauaggagug gcggcaaaaa accaacaaau aacucaugcu      180

aacaacacgg uaucaaauuu caaaagauuu cauggccgug cauucaauga cccguuuaua      240

caaaaagaaa aagaaaauuu aaguuacgau cuaguaccau uaaaaaacgg aggagucggg      300

auaaaaguaa uguauauggg ggaagaacac uuauucuccg uagagcaaau aacagcaaug      360

uuacuaacga aauuaaaaga aacagcagaa aauucccuaa aaaaacccgu uacagauugu      420

guuauuuccg ugccaagcuu cuuuacagac gcagaacgac ggaguguccu ugacgcagcc      480

caaauagucg gacuaaauug ccucagauua augaacgaua ugacagcagu agcacuaaau      540

uauggaauau auaaacaaga ucuacccagc cuagaugaaa agccucgaau aguaguauuu      600

guagauaugg gucauuccgc auuccaagua ucagcuugug cuuuuaacaa aggcaaacuu      660

aaaguacuag gcacagcauu cgacccuuuc cugggaggca aaaacuuuga cgaaaaauua      720

gucgaacauu ucugcgcaga auucaaaaca aaauauaaau uagaugccaa aaguaaaaua      780

cgagcacucu uacgacuaua ucaagaaugu gaaaaauuaa aaaaacuaau gagcucuaac      840

ucuacugacc uaccacuaaa uaucgaaugc uucaugaacg auaaagacgu aucagguaaa      900

augaauagau cacaauucga agaacuaugu gcagaauuac uacaaaaaau agaaguacca      960

cuuuacucac uauuagaaca aacucacuua aaaguagaag augucagcgc aguagaaauc     1020

guagguggcg ccacuagaau accagcagug aaagaaagaa uagcaaaauu uuuuggaaaa     1080

gauauaucaa ccacacuaaa cgccgaugaa gcuguagcac guggcugcgc cuuacaaugc     1140

gcaauucuaa gccccgcauu caaagucaga gaauuuuccg uaacagaugc agugccauuc     1200

ccaauaaguc uaauauggaa ucacgauucc gaagacacug aaggagucca cgaaguauuu     1260

agcagaaauc acgcagcacc auucucaaaa guacuaacau uccuaaggag aggaccuuuu     1320

gagcuagaag cauucuacuc agacccucaa ggaguaccuu acccagaagc aaagauagga     1380

agauucgugg ugcaaaaugu uagcgcacaa aaagauggag aaaaaagcag agucaaaguc     1440

aaaguaagag ucaacacaca uggaauauuu acaaucucaa cagcauccau ggucgaaaag     1500

gucccaacag aagaaaacga aaugaguagc gaagcagaca uggaaugucu aaaucaaaga     1560

ccgccagaaa auccggauac ugauaaaaac gugcaacagg auaacagcga agcaggaacc     1620

caaccacaag uucaaacaga ugcacaacag acaucacagu ccccuccauc acccgaacuc     1680

accucggaag aaaacaaaau accagacgcu gacaaagcaa acgaaaaaaa aguagaucaa     1740

ccaccagaag cuaaaaaacc uaaaauaaaa guaguaaacg ucgaacuacc cauagaggca     1800

aaccucguau ggcaauuagg aaaagaucuc cucaauaugu auauugaaac cgaagggaag     1860

augauuaugc aagauaaacu agagaaagaa agaaacgaug cuaaaaaugc aguugaggaa     1920

uacguauacg aauuuagaga caaauuaugu ggaccauacg aaaaauucau augcgaacaa     1980

gaccaccaaa auuuccuaag auuacuuaca gaaacagaag auuggcucua ugaagaaggc     2040

gaggaucaag ccaaacaagc auacguagac aaacuagaag aauuaaugaa gaucggcaca     2100

ccagucaaag uaagauuuca ggaagcugaa gaaagaccaa aaauguucga agaacucggg     2160

caacgauuac aacacuacgc aaaaauagca gcagacuuca gaaacaagga ugaaaaauac     2220

aaucacauag acgaaucaga aaugaaaaaa guagaaaagu ccguaaauga aguaauggaa     2280

uggaugaaua acgugaugaa cgcacaggca aaaaaaaguc ucgaccaaga cccaguaguu     2340

cgugcacaag aaauaaaaac aaaaauaaaa gaauugaaca acacauguga accaguagua     2400

acacaaccua aaccaaaaau cgaaucaccc aaacuagaac gaacaccaaa cggcccaaac     2460

auagauaaaa aagaggaaga cuuagaagac aaaaauaauu uuggagcaga accaccacau     2520

cagaacggag aaugcuaucc aaaugaaaaa aauucaguaa auauggauuu agacuaa        2577


<210>  7641
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP27__Homo_sapiens__P04792

<400>  7641

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  7642
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP27__Homo_sapiens__AAB51056

<400>  7642
augaccgagc gccgcguccc cuucucgcuc cugcggggcc ccagcuggga ccccuuccgc       60

gacugguacc cgcauagccg ccucuucgac caggccuucg ggcugccccg gcugccggag      120

gaguggucgc agugguuagg cggcagcagc uggccaggcu acgugcgccc ccugcccccc      180

gccgccaucg agagccccgc aguggccgcg cccgccuaca gccgcgcgcu cagccggcaa      240

cucagcagcg gggucucgga gauccggcac acugcggacc gcuggcgcgu gucccuggau      300

gucaaccacu ucgccccgga cgagcugacg gucaagacca aggauggcgu gguggagauc      360

accggcaagc acgaggagcg gcaggacgag cauggcuaca ucucccggug cuucacgcgg      420

aaauacacgc ugccccccgg uguggacccc acccaaguuu ccuccucccu guccccugag      480

ggcacacuga ccguggaggc ccccaugccc aagcuagcca cgcaguccaa cgagaucacc      540

aucccaguca ccuucgaguc gcgggcccag cuugggggcc cagaagcugc aaaauccgau      600

gagacugccg ccaaguaa                                                    618


<210>  7643
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP27__Homo_sapiens__AAB51056

<400>  7643
augaccgagc gccgggugcc cuucagccug cuccgcggcc cguccuggga ccccuuccgg       60

gacugguacc cccacagccg ccuguucgac caggccuucg ggcugccccg gcucccggag      120

gagugguccc aguggcuggg cgggagcucc uggcccggcu acguccgccc ccugcccccg      180

gccgcgaucg agagccccgc cguggccgcc cccgccuacu cccgggcgcu cagccgccag      240

cuguccagcg ggguguccga gauccggcac accgccgacc gcuggcgggu cagccuggac      300

gugaaccacu ucgcccccga cgagcucacg gugaagacca aggacggcgu cguggagauc      360

accggcaagc acgaggagcg ccaggacgag cacggguaca ucucccggug cuucacccgc      420

aaguacacgc ugccgcccgg cguggacccc acccagguca gcuccagccu gucccccgag      480

gggacccuca ccguggaggc cccgaugccc aagcuggcga cgcagagcaa cgagaucacc      540

auccccguga ccuucgaguc ccgggcccag cugggcgggc ccgaggccgc caagagcgac      600

gagaccgccg cgaaguga                                                    618


<210>  7644
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP27__Homo_sapiens__AAB51056

<400>  7644
augaccgagc gccgcguccc cuucucccuc cuccgcggcc ccuccuggga ccccuuccgc       60

gacugguacc cccacucccg ccucuucgac caggccuucg gccucccccg ccuccccgag      120

gagugguccc aguggcucgg cggcuccucc uggcccggcu acguccgccc ccuccccccc      180

gccgccaucg agucccccgc cgucgccgcc cccgccuacu cccgcgcccu cucccgccag      240

cucuccuccg gcgucuccga gauccgccac accgccgacc gcuggcgcgu cucccucgac      300

gucaaccacu ucgcccccga cgagcucacc gucaagacca aggacggcgu cgucgagauc      360

accggcaagc acgaggagcg ccaggacgag cacggcuaca ucucccgcug cuucacccgc      420

aaguacaccc ucccccccgg cgucgacccc acccaggucu ccuccucccu cucccccgag      480

ggcacccuca ccgucgaggc ccccaugccc aagcucgcca cccaguccaa cgagaucacc      540

auccccguca ccuucgaguc ccgcgcccag cucggcggcc ccgaggccgc caaguccgac      600

gagaccgccg ccaaguga                                                    618


<210>  7645
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP27__Homo_sapiens__AAB51056

<400>  7645
augaccgaga gaagggugcc cuucagccug cuccggggcc cuuccuggga cccauuucgc       60

gauugguacc cgcacucucg acuuuucgac caggccuuug ggcugccccg uuugccugaa      120

gaguggucac aaugguuagg agguaguagc uggccaggcu augucagacc ccugccucca      180

gcugcaaucg aaucccccgc cguugcggcu ccugccuacu cuagggcacu aucgcggcag      240

cucucaagcg gggugaguga gauucgccau acagccgaua gauggagggu aucccuggac      300

gugaaccacu ucgcuccaga ugaacuuacu gucaagacga aagacggagu gguugagaua      360

accggcaagc augaggaacg gcaggaugag cacgguuaua ucucucgcug cuuuacacga      420

aaauacacuc ugccgcccgg gguggacccu acccagguca gcuccucauu gaguccagaa      480

ggaacacuca ccguggaggc acccaugccu aagcuggcca cucaaagcaa ugagauuaca      540

aucccaguaa ccuucgaauc uagagcucag cugggcggcc ccgaggccgc gaaauccgau      600

gaaacggcag ccaaguga                                                    618


<210>  7646
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP27__Homo_sapiens__AAB51056

<400>  7646
augaccgaga gaagagugcc cuucagccug cugagaggcc ccagcuggga ccccuucaga       60

gacugguacc cccacagcag acuguucgac caggccuucg gccugcccag acugcccgag      120

gaguggagcc aguggcuggg cggcagcagc uggcccggcu acgugagacc ccugcccccc      180

gccgccaucg agagccccgc cguggccgcc cccgccuaca gcagagcccu gagcagacag      240

cugagcagcg gcgugagcga gaucagacac accgccgaca gauggagagu gagccuggac      300

gugaaccacu ucgcccccga cgagcugacc gugaagacca aggacggcgu gguggagauc      360

accggcaagc acgaggagag acaggacgag cacggcuaca ucagcagaug cuucaccaga      420

aaguacaccc ugccccccgg cguggacccc acccagguga gcagcagccu gagccccgag      480

ggcacccuga ccguggaggc ccccaugccc aagcuggcca cccagagcaa cgagaucacc      540

auccccguga ccuucgagag cagagcccag cugggcggcc ccgaggccgc caagagcgac      600

gagaccgccg ccaaguga                                                    618


<210>  7647
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP27__Homo_sapiens__AAB51056

<400>  7647
augaccgaga gacgggugcc cuucagccug cuccgcggcc cuuccuggga cccguuuaga       60

gauugguacc cccacucucg gcuguucgac caggccuuug ggcuuccucg ccugcccgaa      120

gaguggagcc aauggcucgg aggcuccucu uggccugggu augucagacc ccugccuccg      180

gcugccaucg aaagccccgc gguugcugcc ccugccuacu cccgggcucu uucucgccag      240

cugagcuccg gagugagcga gauuagacau acagccgauc gguggcgcgu gucucucgac      300

gucaaccacu ucgcucccga ugaacugacg gugaagacca aagacggcgu uguggagauc      360

acagggaagc augaggaaag acaggaugag cacggauaua uuucccggug cuuuacccgc      420

aaauacacac ugccucccgg cgucgacccg acccaggugu cuagcucccu cagcccugaa      480

ggcacacuga ccguugaggc ccccaugccu aagcuggcga cgcaaucuaa ugagaucacc      540

auucccguga cauucgaauc cagagcccag cuugggggac ccgaggcugc caaaagcgau      600

gaaaccgcug ccaaguga                                                    618


<210>  7648
<211>  618
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP27__Homo_sapiens__AAB51056

<400>  7648
augacagaaa gaagaguacc uuucucauua uuaagaggac caucauggga uccauuucga       60

gauugguauc cacauagcag acucuuugau caagcauuug gauuaccuag acuaccugaa      120

gaauggucac aauggcuagg aggaucauca uggccaggau acguaagacc auuaccacca      180

gcagcaauag aaucaccagc aguagcagca ccagcauauu cacgagcauu aaguagacaa      240

uuaagcucag gcguuucaga aauaagacac acagcugaca gauggagagu aagcuuagac      300

guaaaccauu ucgcaccaga ugaauuaaca guaaaaacaa aagacggagu aguagaaaua      360

acaggaaaac acgaagaaag acaagaugaa cauggauaua uaucaagaug uuucacaaga      420

aaauacacac uaccaccagg aguagaucca acucaaguaa gcucaagcuu aucaccagaa      480

ggaaccuuaa caguagaagc accaaugcca aaacuagcaa cccaaucaaa ugaaauaaca      540

auacccguaa cauuugaaag uagagcacaa uuaggaggac cagaagcagc aaaaucagac      600

gaaacagcag caaaauaa                                                    618


<210>  7649
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP47_(serpin_H1)__Homo_sapiens__P50454

<400>  7649

Met Arg Ser Leu Leu Leu Leu Ser Ala Phe Cys Leu Leu Glu Ala Ala 
1               5                   10                  15      


Leu Ala Ala Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr 
            20                  25                  30          


Ala Glu Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala 
        35                  40                  45              


Gly Leu Ala Phe Ser Leu Tyr Gln Ala Met Ala Lys Asp Gln Ala Val 
    50                  55                  60                  


Glu Asn Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu 
65                  70                  75                  80  


Val Ser Leu Gly Gly Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val 
                85                  90                  95      


Leu Ser Ala Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly 
            100                 105                 110         


Glu Leu Leu Arg Ser Leu Ser Asn Ser Thr Ala Arg Asn Val Thr Trp 
        115                 120                 125             


Lys Leu Gly Ser Arg Leu Tyr Gly Pro Ser Ser Val Ser Phe Ala Asp 
    130                 135                 140                 


Asp Phe Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys 
145                 150                 155                 160 


Ile Asn Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp 
                165                 170                 175     


Ala Ala Gln Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp Val 
            180                 185                 190         


Glu Arg Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro 
        195                 200                 205             


His Trp Asp Glu Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe 
    210                 215                 220                 


Met Val Thr Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg Thr 
225                 230                 235                 240 


Gly Leu Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val 
                245                 250                 255     


Glu Met Pro Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro 
            260                 265                 270         


His His Val Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu 
        275                 280                 285             


Gln Leu Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile 
    290                 295                 300                 


Ser Leu Pro Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys His 
305                 310                 315                 320 


Leu Ala Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp 
                325                 330                 335     


Leu Ser Arg Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe 
            340                 345                 350         


His Ala Thr Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln 
        355                 360                 365             


Asp Ile Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala 
    370                 375                 380                 


Asp His Pro Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser Leu 
385                 390                 395                 400 


Leu Phe Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp 
                405                 410                 415     


Glu Leu 
        


<210>  7650
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7650
augcgcuccc uccugcuucu cagcgccuuc ugccuccugg aggcggcccu ggccgccgag       60

gugaagaaac cugcagccgc agcagcuccu ggcacugcgg agaaguugag ccccaaggcg      120

gccacgcuug ccgagcgcag cgccggccug gccuucagcu uguaccaggc cauggccaag      180

gaccaggcag uggagaacau ccugguguca cccguggugg uggccucguc gcuggggcuc      240

gugucgcugg gcggcaaggc gaccacggcg ucgcaggcca aggcagugcu gagcgccgag      300

cagcugcgcg acgaggaggu gcacgccggc cugggcgagc ugcugcgcuc acucagcaac      360

uccacggcgc gcaacgugac cuggaagcug ggcagccgac uguacggacc cagcucagug      420

agcuucgcug augacuucgu gcgcagcagc aagcagcacu acaacugcga gcacuccaag      480

aucaacuucc gcgacaagcg cagcgcgcug caguccauca acgagugggc cgcgcagacc      540

accgacggca agcugcccga ggucaccaag gacguggagc gcacggacgg cgcccuguua      600

gucaacgcca uguucuucaa gccacacugg gaugagaaau uccaccacaa gaugguggac      660

aaccguggcu ucauggugac ucgguccuau accgugggug ucaugaugau gcaccggaca      720

ggccucuaca acuacuacga cgacgagaag gaaaagcugc aaaucgugga gaugccccug      780

gcccacaagc ucuccagccu caucauccuc augccccauc acguggagcc ucucgagcgc      840

cuugaaaagc ugcuaaccaa agagcagcug aagaucugga uggggaagau gcagaagaag      900

gcuguugcca ucuccuugcc caagggugug guggagguga cccaugaccu gcagaaacac      960

cuggcugggc ugggccugac ugaggccauu gacaagaaca aggccgacuu gucacgcaug     1020

ucaggcaaga aggaccugua ccuggccagc guguuccacg ccaccgccuu ugaguuggac     1080

acagauggca accccuuuga ccaggacauc uacgggcgcg aggagcugcg cagccccaag     1140

cuguucuacg ccgaccaccc cuucaucuuc cuagugcggg acacccaaag cggcucccug     1200

cuauucauug ggcgccuggu ccggccuaag ggugacaaga ugcgagacga guuauag        1257


<210>  7651
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7651
augcgcagcc ugcuccugcu guccgccuuc ugccuccugg aggccgcgcu ggccgccgag       60

gugaagaagc ccgccgccgc ggccgccccg ggcaccgccg agaagcucag ccccaaggcg      120

gccacccugg ccgagcgguc cgccgggcug gccuucagcc ucuaccaggc gauggccaag      180

gaccaggccg ucgagaacau ccuggugucc cccguggucg uggccagcuc ccugggccuc      240

gugagccucg ggggcaaggc cacgaccgcg ucccaggcca aggccguccu gagcgccgag      300

cagcugcgcg acgaggaggu gcacgccggg cugggcgagc ugcuccgguc ccugagcaac      360

uccaccgcgc gcaacgugac cuggaagcug ggcagccggc ucuacgggcc cuccagcguc      420

uccuucgccg acgacuucgu gcgcagcucc aagcagcacu acaacugcga gcacagcaag      480

aucaacuucc gggacaagcg cagcgcccug caguccauca acgagugggc cgcccagacg      540

accgacggca agcugccgga ggugaccaag gacgucgagc ggaccgacgg ggcgcuccug      600

gugaacgcca uguucuucaa gccccacugg gacgagaagu uccaccacaa gaugguggac      660

aaccgcggcu ucauggucac gcggagcuac accguggggg ugaugaugau gcaccgcacc      720

ggccuguaca acuacuacga cgacgagaag gagaagcucc agaucgucga gaugccccug      780

gcccacaagc uguccagccu caucauccug augccccacc acguggagcc gcuggagcgg      840

cucgagaagc ugcugaccaa ggagcagcuc aagaucugga ugggcaagau gcagaagaag      900

gccguggcga ucucccugcc caaggggguc guggagguga cgcacgaccu gcagaagcac      960

cucgccggcc uggggcugac cgaggccauc gacaagaaca aggccgaccu cagccgcaug     1020

uccggcaaga aggaccugua ccuggccagc gucuuccacg cgaccgccuu cgagcucgac     1080

accgacggca accccuucga ccaggacauc uacgggcggg aggagcugcg cucccccaag     1140

cuguucuacg ccgaccaccc guucaucuuc cucgugcggg acacgcagag cggcucccug     1200

cuguucaucg ggcgccuggu ccggcccaag ggcgacaaga ugcgcgacga gcucuga        1257


<210>  7652
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7652
augcgcuccc uccuccuccu cuccgccuuc ugccuccucg aggccgcccu cgccgccgag       60

gucaagaagc ccgccgccgc cgccgccccc ggcaccgccg agaagcucuc ccccaaggcc      120

gccacccucg ccgagcgcuc cgccggccuc gccuucuccc ucuaccaggc cauggccaag      180

gaccaggccg ucgagaacau ccucgucucc cccgucgucg ucgccuccuc ccucggccuc      240

gucucccucg gcggcaaggc caccaccgcc ucccaggcca aggccguccu cuccgccgag      300

cagcuccgcg acgaggaggu ccacgccggc cucggcgagc uccuccgcuc ccucuccaac      360

uccaccgccc gcaacgucac cuggaagcuc ggcucccgcc ucuacggccc cuccuccguc      420

uccuucgccg acgacuucgu ccgcuccucc aagcagcacu acaacugcga gcacuccaag      480

aucaacuucc gcgacaagcg cuccgcccuc caguccauca acgagugggc cgcccagacc      540

accgacggca agcuccccga ggucaccaag gacgucgagc gcaccgacgg cgcccuccuc      600

gucaacgcca uguucuucaa gccccacugg gacgagaagu uccaccacaa gauggucgac      660

aaccgcggcu ucauggucac ccgcuccuac accgucggcg ucaugaugau gcaccgcacc      720

ggccucuaca acuacuacga cgacgagaag gagaagcucc agaucgucga gaugccccuc      780

gcccacaagc ucuccucccu caucauccuc augccccacc acgucgagcc ccucgagcgc      840

cucgagaagc uccucaccaa ggagcagcuc aagaucugga ugggcaagau gcagaagaag      900

gccgucgcca ucucccuccc caagggcguc gucgagguca cccacgaccu ccagaagcac      960

cucgccggcc ucggccucac cgaggccauc gacaagaaca aggccgaccu cucccgcaug     1020

uccggcaaga aggaccucua ccucgccucc gucuuccacg ccaccgccuu cgagcucgac     1080

accgacggca accccuucga ccaggacauc uacggccgcg aggagcuccg cucccccaag     1140

cucuucuacg ccgaccaccc cuucaucuuc cucguccgcg acacccaguc cggcucccuc     1200

cucuucaucg gccgccucgu ccgccccaag ggcgacaaga ugcgcgacga gcucuga        1257


<210>  7653
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7653
augagaagcc ugcuccuucu guccgccuuc ugcuuguuag aggcugcacu ggccgcggaa       60

gugaagaaac ccgcugccgc agccgcuccu ggcaccgcag agaagcuauc uccaaaagcc      120

gcuacacucg ccgaaagguc agcggggcug gcauuuaguc uuuaccaggc cauggcuaag      180

gaccaagccg ucgagaacau ccugguuagc ccggugguag uggcauccuc uuugggacuc      240

gucucgcugg guggcaaagc uacuacggcc ucacaggcga aggccgugcu gagcgcagaa      300

cagcuccggg augaggaggu ucacgcuggg uuaggagaac ugcuucgcag uuuguccaau      360

ucuaccgccc gaaacgugac auggaagcug ggcagccguc uauauggucc cuccucaguc      420

aguuucgcug acgauuuugu gagaagcucu aaacagcauu acaauuguga gcacuccaag      480

auuaacuuca gggacaaacg gucagcccuc caaagcauaa augaaugggc agcccagacu      540

accgauggga agcugccuga gguaacaaaa gacguugagc gcaccgaugg agcgcuucug      600

gugaacgcua uguuuuucaa gccacauugg gacgaaaagu uucaccauaa aauggucgau      660

aauagaggcu ucauggugac uaggaguuau acagugggcg ucaugaugau gcaccggacc      720

ggguuguaca acuauuacga cgaugagaag gaaaaacucc agaucguuga gaugccccug      780

gcacacaagu uaucuucccu gauuauccuc augccucauc acguggaacc acuugagcgc      840

cuggagaaau ugcuaacgaa ggaacagcug aaaauuugga ugggaaagau gcaaaagaaa      900

gccguagcua ucagccuccc caagggugug gucgagguga cucaugaccu gcagaaacac      960

cuugccggcc ugggguugac cgaagcaaua gauaagaaua aagccgaccu cucgcgaaug     1020

ucuggaaaga aggaccugua uuuagcuucc guuuuucacg ccacagcauu cgagcuggau     1080

acugacggca acccuuuuga ucaggacauc uacgguagag aggaacuaag gucaccaaaa     1140

cucuucuacg cggaucaucc guuuauuuuc cuggugcggg acacccagag ugggagccuu     1200

uuguucaucg gacgucuggu ccgccccaag ggcgauaaaa ugagagacga gcucuga        1257


<210>  7654
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7654
augagaagcc ugcugcugcu gagcgccuuc ugccugcugg aggccgcccu ggccgccgag       60

gugaagaagc ccgccgccgc cgccgccccc ggcaccgccg agaagcugag ccccaaggcc      120

gccacccugg ccgagagaag cgccggccug gccuucagcc uguaccaggc cauggccaag      180

gaccaggccg uggagaacau ccuggugagc cccguggugg uggccagcag ccugggccug      240

gugagccugg gcggcaaggc caccaccgcc agccaggcca aggccgugcu gagcgccgag      300

cagcugagag acgaggaggu gcacgccggc cugggcgagc ugcugagaag ccugagcaac      360

agcaccgcca gaaacgugac cuggaagcug ggcagcagac uguacggccc cagcagcgug      420

agcuucgccg acgacuucgu gagaagcagc aagcagcacu acaacugcga gcacagcaag      480

aucaacuuca gagacaagag aagcgcccug cagagcauca acgagugggc cgcccagacc      540

accgacggca agcugcccga ggugaccaag gacguggaga gaaccgacgg cgcccugcug      600

gugaacgcca uguucuucaa gccccacugg gacgagaagu uccaccacaa gaugguggac      660

aacagaggcu ucauggugac cagaagcuac accgugggcg ugaugaugau gcacagaacc      720

ggccuguaca acuacuacga cgacgagaag gagaagcugc agaucgugga gaugccccug      780

gcccacaagc ugagcagccu gaucauccug augccccacc acguggagcc ccuggagaga      840

cuggagaagc ugcugaccaa ggagcagcug aagaucugga ugggcaagau gcagaagaag      900

gccguggcca ucagccugcc caagggcgug guggagguga cccacgaccu gcagaagcac      960

cuggccggcc ugggccugac cgaggccauc gacaagaaca aggccgaccu gagcagaaug     1020

agcggcaaga aggaccugua ccuggccagc guguuccacg ccaccgccuu cgagcuggac     1080

accgacggca accccuucga ccaggacauc uacggcagag aggagcugag aagccccaag     1140

cuguucuacg ccgaccaccc cuucaucuuc cuggugagag acacccagag cggcagccug     1200

cuguucaucg gcagacuggu gagacccaag ggcgacaaga ugagagacga gcuguga        1257


<210>  7655
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7655
augagaagcc ugcuccugcu uuccgccuuc ugccugcucg aggcugcccu ggcggcugaa       60

gugaagaaac ccgccgccgc ugccgcuccu ggcaccgccg agaaacuuuc uccgaaggcg      120

gccacacugg cugaacggag cgccgggcuc gcuuuuuccc uguaccaggc cauggcgaag      180

gaccaagccg ucgagaacau ccugguuucu cccguggugg ucgcuagcuc ccucggacug      240

gugucucuug gcgggaaagc cacgaccgcu agccaggcca aggccguucu guccgcugaa      300

cagcuccgcg augaggaggu gcacgcggga cugggcgaac uucugagaag ccucucuaau      360

uccacagccc ggaacgucac cuggaagcug gggagccgcc uguauggacc uucuuccgug      420

agcuucgcug acgauuuugu uagaucuucc aaacagcauu acaauuguga gcacagcaag      480

auuaacuucc gggacaaacg cuccgcccuc caaucuauca augaaugggc cgcucagaca      540

accgauggca agcugcccga ggugacaaaa gacgucgaga gaaccgaugg cgcccuucug      600

gugaacgcga uguuuuucaa gccucauugg gacgaaaagu uucaccauaa aaugguggau      660

aaucgggggu ucauggucac gcgcagcuau accguuggag ugaugaugau gcacagaaca      720

ggccucuaca acuauuacga cgaugagaag gaaaaacugc agauugugga gaugccccuu      780

gcucacaagc uguccagccu caucauucug augccucauc acgucgaacc gcuggagcgg      840

cucgagaaac ugcuuaccaa ggaacagcug aaaaucugga uggggaagau gcaaaagaaa      900

gccguggcca ucucucuccc caagggaguu guggagguca cacaugaccu gcagaaacac      960

cuugcuggcc uggggcucac cgaagccauu gauaagaaua aagcugaccu gucccgcaug     1020

agcggaaaga aggaccugua ucucgccucu guguuucacg cgacggccuu cgagcuggau     1080

acagacggca acccuuuuga ucaggacauc uacggcagag aggaacuucg gagccccaaa     1140

cuguucuacg cugaucaucc uuuuauuuuc cucguucgcg acacccaguc cgggucucug     1200

cuguucaucg gaagacuugu gcggcccaag ggcgauaaaa ugagagacga gcucuga        1257


<210>  7656
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP47_(serpin_H1)__Homo_sapiens__AAH14623

<400>  7656
augcgaagcc uacuauuauu aagcgccuuc ugucuacuag aagcagcauu agccgcagaa       60

guaaaaaaac cagcagcagc agccgcacca ggaaccgcgg aaaaacuauc accaaaagca      120

gcaacacuag cagaacgcuc agcuggacua gcauucucau uauaucaagc aauggcaaaa      180

gaucaagcag uagaaaacau ucuaguauca ccaguuguag uagcuucauc ccuaggacua      240

guaagccuag gcggaaaagc aacuacagca ucacaagcaa aagcaguccu aagcgcagaa      300

caacuaagag acgaagaagu acacgcaggc uuaggagaau uauugcgauc auuaucgaac      360

ucaacagcaa gaaauguaac auggaaauug ggaagucggc uauauggacc aaguucagua      420

ucauucgcag acgauuucgu aagaucaucc aaacaacauu acaauugcga acacucuaaa      480

auaaacuuua gagauaaaag aagugcacua caauccauaa augaaugggc agcacaaacc      540

acagauggaa aacuaccaga gguaacaaaa gauguagaaa gaacagacgg agccuuauua      600

gugaaugcaa uguuuuucaa accccauugg gaugaaaaau uucaccauaa aaugguggau      660

aauagaggau ucaugguaac cagaucauac acgguaggag uaaugaugau gcauagaaca      720

ggacuauaua acuauuauga ugacgaaaaa gaaaaauuac aaauaguaga aaugccacua      780

gcccauaaac uuucaagucu aauaauacuu augccacauc auguugaacc acuagaaaga      840

cuagaaaaac uccugacaaa agaacaauua aaaauaugga ugggaaaaau gcaaaaaaaa      900

gcuguugcaa uaucacuacc aaaaggaguu guagaaguaa cccaugacuu acaaaaacac      960

uuagcaggac uaggacuaac ggaagcaaua gauaaaaaua aagcggacuu auccagaaug     1020

ucagguaaaa aagaucuaua ucuugcgagu guauuccacg caacagcauu cgaacuagau     1080

acugacggaa auccauuuga ucaagauauc uauggaagag aagaacucag gaguccaaaa     1140

cuauucuaug ccgaucaccc auuuauauuc uuagucagag auacgcaauc ggguucauua     1200

uuauuuauag gaagacuagu aagaccaaaa ggagauaaaa ugagagacga acuauag        1257


<210>  7657
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__A0A024R3X4

<400>  7657

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  7658
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__EAW70148

<400>  7658
augcuucggu uacccacagu cuuucgccag augagaccgg uguccagggu acuggcuccu       60

caucucacuc gggcuuaugc caaagaugua aaauuuggug cagaugcccg agccuuaaug      120

cuucaaggug uagaccuuuu agccgaugcu guggccguua caauggggcc aaagggaaga      180

acagugauua uugagcagag uuggggaagu cccaaaguaa caaaagaugg ugugacuguu      240

gcaaagucaa uugacuuaaa agauaaauac aaaaacauug gagcuaaacu uguucaagau      300

guugccaaua acacaaauga agaagcuggg gauggcacua ccacugcuac uguacuggca      360

cgcucuauag ccaaggaagg cuucgagaag auuagcaaag gugcuaaucc aguggaaauc      420

aggagaggug ugauguuagc uguugaugcu guaauugcug aacuuaaaaa gcagucuaaa      480

ccugugacca ccccugaaga aauugcacag guugcuacga uuucugcaaa cggagacaaa      540

gaaauuggca auaucaucuc ugaugcaaug aaaaaaguug gaagaaaggg ugucaucaca      600

guaaaggaug gaaaaacacu gaaugaugaa uuagaaauua uugaaggcau gaaguuugau      660

cgaggcuaua uuucuccaua cuuuauuaau acaucaaaag gucagaaaug ugaauuccag      720

gaugccuaug uucuguugag ugaaaagaaa auuucuagua uccaguccau uguaccugcu      780

cuugaaauug ccaaugcuca ccguaagccu uuggucauaa ucgcugaaga uguugaugga      840

gaagcucuaa guacacucgu cuugaauagg cuaaagguug gucuucaggu uguggcaguc      900

aaggcuccag gguuugguga caauagaaag aaccagcuua aagauauggc uauugcuacu      960

gguggugcag uguuuggaga agagggauug acccugaauc uugaagacgu ucagccucau     1020

gacuuaggaa aaguuggaga ggucauugug accaaagacg augccaugcu cuuaaaagga     1080

aaaggugaca aggcucaaau ugaaaaacgu auucaagaaa ucauugagca guuagauguc     1140

acaacuagug aauaugaaaa ggaaaaacug aaugaacggc uugcaaaacu uucagaugga     1200

guggcugugc ugaagguugg ugggacaagu gauguugaag ugaaugaaaa gaaagacaga     1260

guuacagaug cccuuaaugc uacaagagcu gcuguugaag aaggcauugu uuugggaggg     1320

gguugugccc uccuucgaug cauuccagcc uuggacucau ugacuccagc uaaugaagau     1380

caaaaaauug guauagaaau uauuaaaaga acacucaaaa uuccagcaau gaccauugcu     1440

aagaaugcag guguugaagg aucuuugaua guugagaaaa uuaugcaaag uuccucagaa     1500

guugguuaug augcuauggc uggagauuuu gugaauaugg uggaaaaagg aaucauugac     1560

ccaacaaagg uugugagaac ugcuuuauug gaugcugcug guguggccuc ucuguuaacu     1620

acagcagaag uuguagucac agaaauuccu aaagaagaga aggacccugg aaugggugca     1680

auggguggaa ugggaggugg uaugggaggu ggcauguucu aa                        1722


<210>  7659
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP60__Homo_sapiens__EAW70148

<400>  7659
augcugcgcc uccccaccgu guuccggcag augcgcccgg ucagccgggu gcuggcgccc       60

caccugaccc gcgccuacgc caaggacgug aaguucgggg ccgacgcccg ggcccucaug      120

cugcaggggg ucgaccugcu cgccgacgcg guggccguga cgaugggccc caaggggcgc      180

accgucauca ucgagcaguc cuggggcagc cccaagguga ccaaggacgg ggugaccguc      240

gccaagucca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggcgaaca acacgaacga ggaggccggc gacgggacca ccaccgccac gguccucgcc      360

cggagcaucg ccaaggaggg cuucgagaag aucuccaagg gggcgaaccc gguggagauc      420

cgccggggcg ugaugcuggc cgucgacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag gucgcgacca ucuccgccaa cggggacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gccgcaaggg ggugaucacg      600

gucaaggacg gcaagacccu caacgacgag cuggagauca ucgaggggau gaaguucgac      660

cggggcuaca ucucccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcucuc cgagaagaag aucagcucca uccagagcau cgugccggcc      780

cuggagaucg cgaacgccca ccgcaagccc cuggucauca ucgccgagga cguggacggg      840

gaggcccucu ccacccuggu ccugaaccgg cucaaggugg gccuccaggu ggucgccgug      900

aaggcgcccg gguucggcga caaccgcaag aaccagcuga aggacauggc caucgccacc      960

gggggcgccg uguucggcga ggaggggcug acgcugaacc uggaggacgu ccagccccac     1020

gaccucggca agguggggga ggugaucguc accaaggacg acgcgaugcu gcugaagggc     1080

aagggggaca aggcccagau cgagaagcgg auccaggaga ucaucgagca gcucgacgug     1140

accacgagcg aguacgagaa ggagaagcug aacgagcgcc uggccaagcu cuccgacggc     1200

guggccgucc ugaagguggg cgggaccagc gacguggagg ucaacgagaa gaaggaccgg     1260

gugaccgacg cccugaacgc gacccgcgcc gccguggagg agggcaucgu ccucgggggc     1320

gggugcgccc ugcugcggug caucccggcc cucgacuccc ugacgcccgc gaacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg gagccucauc guggagaaga ucaugcagag cuccagcgag     1500

gucggcuacg acgccauggc gggggacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg ucgugcggac ggcccugcug gacgccgccg gcguggcguc ccuccugacc     1620

accgccgagg ucguggugac cgagaucccg aaggaggaga aggaccccgg gaugggcgcc     1680

augggcggga ugggcggggg caugggcggc gggauguucu ga                        1722


<210>  7660
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP60__Homo_sapiens__EAW70148

<400>  7660
augcuccgcc uccccaccgu cuuccgccag augcgccccg ucucccgcgu ccucgccccc       60

caccucaccc gcgccuacgc caaggacguc aaguucggcg ccgacgcccg cgcccucaug      120

cuccagggcg ucgaccuccu cgccgacgcc gucgccguca ccaugggccc caagggccgc      180

accgucauca ucgagcaguc cuggggcucc cccaagguca ccaaggacgg cgucaccguc      240

gccaagucca ucgaccucaa ggacaaguac aagaacaucg gcgccaagcu cguccaggac      300

gucgccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cguccucgcc      360

cgcuccaucg ccaaggaggg cuucgagaag aucuccaagg gcgccaaccc cgucgagauc      420

cgccgcggcg ucaugcucgc cgucgacgcc gucaucgccg agcucaagaa gcaguccaag      480

cccgucacca cccccgagga gaucgcccag gucgccacca ucuccgccaa cggcgacaag      540

gagaucggca acaucaucuc cgacgccaug aagaaggucg gccgcaaggg cgucaucacc      600

gucaaggacg gcaagacccu caacgacgag cucgagauca ucgagggcau gaaguucgac      660

cgcggcuaca ucucccccua cuucaucaac accuccaagg gccagaagug cgaguuccag      720

gacgccuacg uccuccucuc cgagaagaag aucuccucca uccaguccau cguccccgcc      780

cucgagaucg ccaacgccca ccgcaagccc cucgucauca ucgccgagga cgucgacggc      840

gaggcccucu ccacccucgu ccucaaccgc cucaaggucg gccuccaggu cgucgccguc      900

aaggcccccg gcuucggcga caaccgcaag aaccagcuca aggacauggc caucgccacc      960

ggcggcgccg ucuucggcga ggagggccuc acccucaacc ucgaggacgu ccagccccac     1020

gaccucggca aggucggcga ggucaucguc accaaggacg acgccaugcu ccucaagggc     1080

aagggcgaca aggcccagau cgagaagcgc auccaggaga ucaucgagca gcucgacguc     1140

accaccuccg aguacgagaa ggagaagcuc aacgagcgcc ucgccaagcu cuccgacggc     1200

gucgccgucc ucaaggucgg cggcaccucc gacgucgagg ucaacgagaa gaaggaccgc     1260

gucaccgacg cccucaacgc cacccgcgcc gccgucgagg agggcaucgu ccucggcggc     1320

ggcugcgccc uccuccgcug cauccccgcc cucgacuccc ucacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccucaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcgucgaggg cucccucauc gucgagaaga ucaugcaguc cuccuccgag     1500

gucggcuacg acgccauggc cggcgacuuc gucaacaugg ucgagaaggg caucaucgac     1560

cccaccaagg ucguccgcac cgcccuccuc gacgccgccg gcgucgccuc ccuccucacc     1620

accgccgagg ucgucgucac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7661
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP60__Homo_sapiens__EAW70148

<400>  7661
augcugagac uccccaccgu guucaggcag augcggccug ucagccgcgu ucuugcccca       60

caccugacac gagcuuacgc aaaggacgug aaauuuggcg ccgaugcgcg ugcuuugaug      120

uuacaagggg uagaccugcu agccgaugca guggccguca cuaugggacc gaaggguaga      180

acggugauca uugagcaguc cuggggcucu cccaaaguua ccaaggacgg ggugacaguc      240

gcuaaaucaa uagaucucaa ggacaaguau aaaaacaucg gagcaaagcu ggugcaggau      300

guagccaaua acacuaauga agaggcuggc gacgguacca caaccgccac uguucuugcg      360

aggaguauug caaaagaagg guucgagaag aucagcaaag gagccaaccc uguggaaauu      420

cggcgcggcg ucaugcuggc uguggaugcc gugaucgcag aguugaagaa gcaguccaaa      480

ccagucacaa cccccgagga aauagcucaa guugccacga ucucugcgaa uggcgacaag      540

gagauuggga acaucauuuc ggaugccaug aaaaaggugg gaagaaaagg uguaaucacu      600

gugaaggacg gcaaaacccu caaugaugaa cuggagauaa uugaggggau gaaguuugac      660

aggggauaca ucucaccuua uuucauuaac acaagcaagg gccagaaaug cgaauuucag      720

gacgcauacg uccugcucag ugagaagaaa aucuccucua uccagagcau ugugccagcu      780

uuagaaauag ccaaugcuca ucggaagccc cugguuauca uugccgagga uguggacggu      840

gaagcacuuu ccacuuuggu ccugaaccgc cuaaaagugg ggcuccaagu aguugccgug      900

aaggcuccug gauucggcga uaaucgaaag aaccagcuga aagacauggc gaucgcaacc      960

ggcggggccg ucuuuggaga ggagggucuu acacugaauu uggaagaugu gcagccacac     1020

gaccucggca aggucgggga ggugauaguu accaaagaug acgcuaugcu guuaaaggga     1080

aaaggcgaua aggcccagau ugaaaagaga auccaagaga ucauugaaca gcuggacgug     1140

acgacuucag aguaugagaa agaaaagcuc aacgagaggc uugcaaaacu gagugauggu     1200

guagccgucu ugaagguugg gggcacaagc gacguggaag ugaaugagaa aaaggaccgg     1260

gucaccgaug cucuaaacgc cacucgugca gcgguggaag agggaaucgu acugggcggg     1320

ggaugugcuc uccugcgcug cauuccggcc cuugacucuc ugacacccgc aaacgaggau     1380

cagaagauag guaucgaaau uaucaaaaga accuugaaga ucccugccau gacgauugcu     1440

aaaaaugccg gcguggaggg gucccucaua guugaaaaga ucaugcaauc aagcagugag     1500

gucggauacg acgcaauggc uggcgauuuc gugaacaugg uggagaaagg uauuaucgac     1560

ccaaccaagg ucguuaggac agcccuguua gaugcggccg ggguggcuuc ucugcuaacu     1620

accgcagaag ugguagucac agagauuccc aaagaagaga aggacccugg caugggagcc     1680

augggcggga ugggaggugg caugggaggg ggcauguuuu ga                        1722


<210>  7662
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP60__Homo_sapiens__EAW70148

<400>  7662
augcugagac ugcccaccgu guucagacag augagacccg ugagcagagu gcuggccccc       60

caccugacca gagccuacgc caaggacgug aaguucggcg ccgacgccag agcccugaug      120

cugcagggcg uggaccugcu ggccgacgcc guggccguga ccaugggccc caagggcaga      180

accgugauca ucgagcagag cuggggcagc cccaagguga ccaaggacgg cgugaccgug      240

gccaagagca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cgugcuggcc      360

agaagcaucg ccaaggaggg cuucgagaag aucagcaagg gcgccaaccc cguggagauc      420

agaagaggcg ugaugcuggc cguggacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag guggccacca ucagcgccaa cggcgacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gcagaaaggg cgugaucacc      600

gugaaggacg gcaagacccu gaacgacgag cuggagauca ucgagggcau gaaguucgac      660

agaggcuaca ucagccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcugag cgagaagaag aucagcagca uccagagcau cgugcccgcc      780

cuggagaucg ccaacgccca cagaaagccc cuggugauca ucgccgagga cguggacggc      840

gaggcccuga gcacccuggu gcugaacaga cugaaggugg gccugcaggu gguggccgug      900

aaggcccccg gcuucggcga caacagaaag aaccagcuga aggacauggc caucgccacc      960

ggcggcgccg uguucggcga ggagggccug acccugaacc uggaggacgu gcagccccac     1020

gaccugggca aggugggcga ggugaucgug accaaggacg acgccaugcu gcugaagggc     1080

aagggcgaca aggcccagau cgagaagaga auccaggaga ucaucgagca gcuggacgug     1140

accaccagcg aguacgagaa ggagaagcug aacgagagac uggccaagcu gagcgacggc     1200

guggccgugc ugaagguggg cggcaccagc gacguggagg ugaacgagaa gaaggacaga     1260

gugaccgacg cccugaacgc caccagagcc gccguggagg agggcaucgu gcugggcggc     1320

ggcugcgccc ugcugagaug cauccccgcc cuggacagcc ugacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagaga acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg cagccugauc guggagaaga ucaugcagag cagcagcgag     1500

gugggcuacg acgccauggc cggcgacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg uggugagaac cgcccugcug gacgccgccg gcguggccag ccugcugacc     1620

accgccgagg ugguggugac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7663
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP60__Homo_sapiens__EAW70148

<400>  7663
augcugagac uccccaccgu guuccggcag augcgcccug ucagcagagu ucuggccccg       60

caccuuacac gggcuuacgc caaggacgug aaauuuggcg cggaugcucg cgcccugaug      120

cuccaagggg uggaccugcu ugccgaugcu gucgccguga cgaugggacc caagggcaga      180

accguuauca uugagcaguc cugggggucu ccuaaaguga caaaggacgg agucaccgug      240

gcuaaaagca ucgaucugaa ggacaaguau aaaaacauug gcgccaagcu cguucaggau      300

guggcgaaua acacaaauga agaggccggg gacggaacca caaccgcuac gguccuggcc      360

cgguccaucg cuaaagaagg cuucgagaag auuucuaaag gcgccaaccc cguggaaauc      420

cgcagagggg ugaugcuggc ggucgaugcc guuaucgcug agcucaagaa gcagagcaaa      480

ccugugacca cacccgagga aauugcccaa guggcuacca ucuccgccaa uggagacaag      540

gagauuggca acaucauuuc ugaugccaug aaaaaggucg ggcggaaagg agugaucaca      600

guuaaggacg gcaaaacccu gaaugaugaa cuugagauua ucgaggggau gaaguuugac      660

cgcggauaca ucagcccuua uuucauuaac acguccaagg gccagaaaug cgaauuucag      720

gacgcuuacg ugcugcucag cgagaagaaa aucucuucca uucagagcau cgucccggcg      780

cuggaaauug ccaaugcuca uagaaagccc cuugugauca ucgccgagga uguugacggc      840

gaagcccugu cuacacucgu gcugaaccgg cugaaagucg ggcuccaagu ggucgcugug      900

aaggccccug gauucggcga uaaucgcaag aaccagcuga aagacauggc gauugcuacc      960

gggggagccg uuuuuggcga ggaggggcuu acacugaauc ucgaagaugu gcagccccac     1020

gaccugggaa aggucggcga ggugaucguu accaaagaug acgccaugcu ucugaagggc     1080

aaaggggaua aggcucagau ugaaaagaga auccaagaga uuaucgaaca gcucgacgug     1140

accacauccg aguaugagaa agaaaagcug aacgagcggc uggccaaacu cagcgaugga     1200

gucgcugugc ugaagguggg cgggacgucu gacguugaag ucaaugagaa aaaggaccgc     1260

gugaccgaug cccuuaacgc gacaagagcc gcuguggaag agggaaucgu ccugggcggg     1320

ggcugugccc uccugcggug cauuccugcu cuugacuccc ugacccccgc caacgaggau     1380

cagaagaucg gaauugaaau cauuaaaaga acacucaaga ucccggcgau gaccauugcc     1440

aaaaaugcug gcguggaggg gagccugauc guugaaaaga ucaugcaauc cucuagcgag     1500

gugggauacg acgccauggc uggcgauuuc gucaacaugg uggagaaagg gauuaucgac     1560

ccuacgaagg uugugcgcac agcccugcuc gaugccgcug gagucgcguc ccugcuuacc     1620

accgccgaag ugguugugac agagauuccc aaagaagaga aggacccugg caugggggcu     1680

augggcggaa ugggcggggg aaugggcggg ggaauguuuu ga                        1722


<210>  7664
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP60__Homo_sapiens__EAW70148

<400>  7664
augcuaagac uaccgacggu auuuagacaa augagaccag uaaguagagu auuggcacca       60

caccugacaa gagcauaugc gaaagaugua aaauuuggag cagaugcaag agcacuaaug      120

cuacaaggcg uggauuuacu agccgacgca guagcaguua cuaugggacc gaaaggacgg      180

acaguaauua uagaacaaag uugggguagu ccgaaaguaa caaaagaugg ggucacagua      240

gcaaaaucaa uagacuuaaa ggacaaauac aaaaauauag gagcaaaacu aguacaagau      300

guggcaaaua acacaaauga agaagcagga gacggaacaa ccacggcaac aguacuagcu      360

agaaguauag caaaagaagg guuugaaaaa auaagcaaag gagcaaaucc uguagaaaua      420

agaaggggag uaaugcuagc gguagacgcc guuauagcag aguuaaaaaa acaaaguaaa      480

ccaguaacaa caccagagga aauagcacaa guagcaacaa uaagugcaaa uggagauaag      540

gaaauuggaa acauuauauc cgaugccaug aagaaaguag gaagaaaagg gguaauaaca      600

guaaaggaug gaaaaacguu aaaugaugaa cuagaaauaa uagaaggaau gaaauucgac      660

cgaggauaua uuaguccaua uuuuauaaac acaagcaaag gacaaaaaug ugaauuucaa      720

gacgcuuaug uccuauuaag cgaaaaaaaa auaucaagca uacaaucaau uguaccagca      780

cuugaaauag caaaugcaca cagaaaacca uuaguaauaa uugcugaaga uguagacggg      840

gaagcgcuaa gcacauuagu auuaaauaga cuaaaaguag gacuccaagu gguagcagua      900

aaagcuccag gauuuggaga uaauagaaaa aaucaauuaa aagacauggc aauagcaaca      960

gggggagccg uauuuggaga ggaaggucug acauuaaacu uagaggacgu acagccacau     1020

gauuugggaa aaguaggaga aguaauagua acgaaagacg acgcaauguu auugaaagga     1080

aagggagaua aagcgcagau agaaaaaagg auucaagaga uaauagagca auuagaugua     1140

acaacaagug aauaugagaa agaaaaacua aaugaaagau uagcaaaauu gagcgacgga     1200

guagcaguau uaaaaguagg aggaacauca gacguagaag uaaaugaaaa aaaggacaga     1260

guaacagaug cuuugaacgc aacaagagca gccguugaag aaggaauagu auuaggagga     1320

ggaugugcuu uacuaagaug caucccagca cuagauucau uaacgccagc aaaugaagau     1380

caaaaaauag gaauagaaau aauaaaaaga accuuaaaaa uaccagcuau gacaauagca     1440

aaaaacgcag gcguagaggg aagccuaaua guagaaaaaa uaaugcaaag uucaagugaa     1500

guaggguaug acgccauggc uggagauuuu guaaacaugg uagaaaaagg aauaauagau     1560

ccaacaaaag uaguaaggac ggcauuguua gaugcagcag gaguugcaag ccuuuuaaca     1620

accgcagaag uaguagugac agaaauacca aaagaagaaa aagauccagg uaugggggca     1680

augggaggga ugggaggagg aaugggagga ggaauguucu aa                        1722


<210>  7665
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__B3GQS7

<400>  7665

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Gly Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Phe 
                565                 


<210>  7666
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__ACE06961

<400>  7666
augcuucggu uacccacagu cuuucgccag augagaccgg uguccagggu acuggcuccu       60

caucucacuc gggcuuaugc caaagaugua aaauuuggug cagaugcccg agccuuaaug      120

cuucaaggug uagaccuuuu agccgaugcu guggccguua caauggggcc aaagggaaga      180

acagugauua uugagcagag uuggggaagu cccaaaguaa caaaagaugg ugugacuguu      240

gcaaagucaa uugacuuaaa agauaaauac aagaacauug gagcuaaacu uguucaagau      300

guugccaaua acacaaauga agaagcuggg gauggcacua ccacugcuac uguacuggca      360

cgcucuauag ccaaggaagg cuucgagaag auuagcaaag gugcuaaucc aguggaaauc      420

aggagaggug ugauguuagc uguugaugcu guaauugcug aacuuaaaaa gcagucuaaa      480

ccugugacca ccccugaaga aauugcacag guugcuacga uuucugcaaa cggagacaaa      540

gaaauuggca auaucaucuc ugaugcaaug aaaaaaguug gaagaaaggg ugucaucaca      600

guaaaggaug gaaaaacacu gaaugaugaa uuagaaauua uugaaggcau gaaguuugau      660

cgaggcuaua uuucuccaua cuuuauuaau acaucaaaag gucagaaaug ugaauuccag      720

gaugccuaug uucuguugag ugaaaagaaa auuucuagua uccaguccau uguaccugcu      780

cuugaaauug ccaaugcuca ccguaagccu uuggucauaa ucgcugaaga uguugaugga      840

gaagcucuaa guacacucgu cuugaauagg cuaaagguug gucuucaggu uguggcaguc      900

aaggcuccag gguuugguga caauagaaag aaccagcuua aagauauggc uauugcuacu      960

gguggugcag uguuuggaga agagggauug acccugaauc uugaagacgu ucagccucau     1020

gacuuaggaa aaguuggaga ggucauugug accaaagacg augccaugcu cuuaaaagga     1080

aaaggugaca aggcucaaau ugaaaaacgu auucaagaaa ucauugagca guuagauguc     1140

acaacuagug aauaugaaaa gggaaaacug aaugaacggc uugcaaaacu uucagaugga     1200

guggcugugc ugaagguugg ugggacaagu gauguugaag ugaaugaaaa gaaagacaga     1260

guuacagaug cccuuaaugc uacaagagcu gcuguugaag aaggcauugu uuugggaggg     1320

gguugugccc uccuucgaug cauuccagcc uuggacucau ugacuccagc uaaugaagau     1380

caaaaaauug guauagaaau uauuaaaaga acacucaaaa uuccagcaau gaccauugcu     1440

aagaaugcag guguugaagg aucuuugaua guugagaaaa uuaugcaaag uuccucagaa     1500

guugguuaug augcuauggc uggagauuuu gugaauaugg uggaaaaagg aaucauugac     1560

ccaacaaagg uugugagaac ugcuuuauug gaugcugcug guguggccuc ucuguuaacu     1620

acagcagaag uuguagucac agaaauuccu aaagaagaga aggacccugg aaugggugca     1680

auggguggaa ugggaggugg cauguucuaa                                      1710


<210>  7667
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP60__Homo_sapiens__ACE06961

<400>  7667
augcugcgcc uccccaccgu guuccggcag augcgcccgg ucagccgggu gcuggcgccc       60

caccugaccc gcgccuacgc caaggacgug aaguucggcg ccgacgcccg ggcccucaug      120

cugcaggggg ucgaccugcu cgccgacgcg guggccguga cgaugggccc caaggggcgc      180

accgucauca ucgagcaguc cuggggcagc cccaagguga ccaaggacgg ggugaccguc      240

gccaagucca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggcgaaca acacgaacga ggaggccggc gacgggacca ccaccgccac gguccucgcc      360

cggagcaucg ccaaggaggg cuucgagaag aucuccaagg gggcgaaccc gguggagauc      420

cgccggggcg ugaugcuggc cgucgacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag gucgcgacca ucuccgccaa cggggacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gccgcaaggg ggugaucacg      600

gucaaggacg gcaagacccu caacgacgag cuggagauca ucgaggggau gaaguucgac      660

cggggcuaca ucucccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcucuc cgagaagaag aucagcucca uccagagcau cgugccggcc      780

cuggagaucg cgaacgccca ccgcaagccc cuggucauca ucgccgagga cguggacggg      840

gaggcccucu ccacccuggu ccugaaccgg cucaaggugg gccuccaggu ggucgccgug      900

aaggcgcccg gguucggcga caaccgcaag aaccagcuga aggacauggc caucgccacc      960

gggggcgccg uguucggcga ggaggggcug acgcugaacc uggaggacgu ccagccccac     1020

gaccucggca agguggggga ggugaucguc accaaggacg acgcgaugcu gcugaagggc     1080

aagggggaca aggcccagau cgagaagcgg auccaggaga ucaucgagca gcucgacgug     1140

accacgagcg aguacgagaa gggcaagcug aacgagcgcc uggccaagcu cuccgacggc     1200

guggccgucc ugaaggucgg gggcaccagc gacguggagg ugaacgagaa gaaggaccgg     1260

gugaccgacg cccugaacgc gacccgcgcc gccguggagg aggggaucgu ccucggcggg     1320

ggcugcgccc ugcugcggug caucccggcc cucgacuccc ugacgcccgc gaacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg ggguggaggg cagccucauc guggagaaga ucaugcagag cuccagcgag     1500

gucggguacg acgccauggc gggcgacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg ucgugcggac ggcccugcug gacgccgccg ggguggcguc ccuccugacc     1620

accgccgagg ucguggugac cgagaucccg aaggaggaga aggaccccgg caugggggcc     1680

augggcggga ugggcggcgg gauguucuga                                      1710


<210>  7668
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP60__Homo_sapiens__ACE06961

<400>  7668
augcuccgcc uccccaccgu cuuccgccag augcgccccg ucucccgcgu ccucgccccc       60

caccucaccc gcgccuacgc caaggacguc aaguucggcg ccgacgcccg cgcccucaug      120

cuccagggcg ucgaccuccu cgccgacgcc gucgccguca ccaugggccc caagggccgc      180

accgucauca ucgagcaguc cuggggcucc cccaagguca ccaaggacgg cgucaccguc      240

gccaagucca ucgaccucaa ggacaaguac aagaacaucg gcgccaagcu cguccaggac      300

gucgccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cguccucgcc      360

cgcuccaucg ccaaggaggg cuucgagaag aucuccaagg gcgccaaccc cgucgagauc      420

cgccgcggcg ucaugcucgc cgucgacgcc gucaucgccg agcucaagaa gcaguccaag      480

cccgucacca cccccgagga gaucgcccag gucgccacca ucuccgccaa cggcgacaag      540

gagaucggca acaucaucuc cgacgccaug aagaaggucg gccgcaaggg cgucaucacc      600

gucaaggacg gcaagacccu caacgacgag cucgagauca ucgagggcau gaaguucgac      660

cgcggcuaca ucucccccua cuucaucaac accuccaagg gccagaagug cgaguuccag      720

gacgccuacg uccuccucuc cgagaagaag aucuccucca uccaguccau cguccccgcc      780

cucgagaucg ccaacgccca ccgcaagccc cucgucauca ucgccgagga cgucgacggc      840

gaggcccucu ccacccucgu ccucaaccgc cucaaggucg gccuccaggu cgucgccguc      900

aaggcccccg gcuucggcga caaccgcaag aaccagcuca aggacauggc caucgccacc      960

ggcggcgccg ucuucggcga ggagggccuc acccucaacc ucgaggacgu ccagccccac     1020

gaccucggca aggucggcga ggucaucguc accaaggacg acgccaugcu ccucaagggc     1080

aagggcgaca aggcccagau cgagaagcgc auccaggaga ucaucgagca gcucgacguc     1140

accaccuccg aguacgagaa gggcaagcuc aacgagcgcc ucgccaagcu cuccgacggc     1200

gucgccgucc ucaaggucgg cggcaccucc gacgucgagg ucaacgagaa gaaggaccgc     1260

gucaccgacg cccucaacgc cacccgcgcc gccgucgagg agggcaucgu ccucggcggc     1320

ggcugcgccc uccuccgcug cauccccgcc cucgacuccc ucacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccucaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcgucgaggg cucccucauc gucgagaaga ucaugcaguc cuccuccgag     1500

gucggcuacg acgccauggc cggcgacuuc gucaacaugg ucgagaaggg caucaucgac     1560

cccaccaagg ucguccgcac cgcccuccuc gacgccgccg gcgucgccuc ccuccucacc     1620

accgccgagg ucgucgucac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg cauguucuga                                      1710


<210>  7669
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP60__Homo_sapiens__ACE06961

<400>  7669
augcugagac uccccaccgu guucaggcag augcggccug ucagccgcgu ucuugcccca       60

caccugacac gagcuuacgc aaaggacgug aaauuuggcg ccgaugcgcg ugcuuugaug      120

uuacaagggg uagaccugcu agccgaugca guggccguca cuaugggacc gaaggguaga      180

acggugauca uugagcaguc cuggggcucu cccaaaguua ccaaggacgg ggugacaguc      240

gcuaaaucaa uagaucucaa ggacaaguau aaaaacaucg gagcaaagcu ggugcaggau      300

guagccaaua acacuaauga agaggcuggc gacgguacca caaccgccac uguucuugcg      360

aggaguauug caaaagaagg guucgagaag aucagcaaag gagccaaccc uguggaaauu      420

cggcgcggcg ucaugcuggc uguggaugcc gugaucgcag aguugaagaa gcaguccaaa      480

ccagucacaa cccccgagga aauagcucaa guugccacga ucucugcgaa uggcgacaag      540

gagauuggga acaucauuuc ggaugccaug aaaaaggugg gaagaaaagg uguaaucacu      600

gugaaggacg gcaaaacccu caaugaugaa cuggagauaa uugaggggau gaaguuugac      660

aggggauaca ucucaccuua uuucauuaac acaagcaagg gccagaaaug cgaauuucag      720

gacgcauacg uccugcucag ugagaagaaa aucuccucua uccagagcau ugugccagcu      780

uuagaaauag ccaaugcuca ucggaagccc cugguuauca uugccgagga uguggacggu      840

gaagcacuuu ccacuuuggu ccugaaccgc cuaaaagugg ggcuccaagu aguugccgug      900

aaggcuccug gauucggcga uaaucgaaag aaccagcuga aagacauggc gaucgcaacc      960

ggcggggccg ucuuuggaga ggagggucuu acacugaauu uggaagaugu gcagccacac     1020

gaccucggca aggucgggga ggugauaguu accaaagaug acgcuaugcu guuaaaggga     1080

aaaggcgaua aggcccagau ugaaaagaga auccaagaga ucauugaaca gcuggacgug     1140

acgacuucag aguaugagaa agguaagcuc aacgaaaggc uugcaaaacu gagugauggg     1200

guagccgucu ugaagguggg cggaacaagc gacguugagg ugaaugagaa aaaggaccgg     1260

gucaccgaug cucuaaacgc cacucgugca gcgguggaag aaggcaucgu acucggggga     1320

gguugugcuc ugcugcgcug cauuccggcc cuugacucuc ugacacccgc aaacgaggau     1380

cagaagauag gcaucgagau uaucaaaaga accuugaaga ucccugccau gacgauugcu     1440

aaaaaugccg ggguggaagg aucccucaua guugagaaga ucaugcaauc aagcagugaa     1500

gucggcuacg acgcaauggc uggugauuuc gugaacaugg uggagaaagg gauuaucgac     1560

ccaaccaagg ucguuaggac agcccuguua gaugcggccg gcguggcuuc ucugcuaacu     1620

accgcagagg ugguagucac agaaauuccc aaagaggaaa aggacccugg aaugggcgcc     1680

augggaggga uggguggcgg gauguuuuga                                      1710


<210>  7670
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP60__Homo_sapiens__ACE06961

<400>  7670
augcugagac ugcccaccgu guucagacag augagacccg ugagcagagu gcuggccccc       60

caccugacca gagccuacgc caaggacgug aaguucggcg ccgacgccag agcccugaug      120

cugcagggcg uggaccugcu ggccgacgcc guggccguga ccaugggccc caagggcaga      180

accgugauca ucgagcagag cuggggcagc cccaagguga ccaaggacgg cgugaccgug      240

gccaagagca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cgugcuggcc      360

agaagcaucg ccaaggaggg cuucgagaag aucagcaagg gcgccaaccc cguggagauc      420

agaagaggcg ugaugcuggc cguggacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag guggccacca ucagcgccaa cggcgacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gcagaaaggg cgugaucacc      600

gugaaggacg gcaagacccu gaacgacgag cuggagauca ucgagggcau gaaguucgac      660

agaggcuaca ucagccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcugag cgagaagaag aucagcagca uccagagcau cgugcccgcc      780

cuggagaucg ccaacgccca cagaaagccc cuggugauca ucgccgagga cguggacggc      840

gaggcccuga gcacccuggu gcugaacaga cugaaggugg gccugcaggu gguggccgug      900

aaggcccccg gcuucggcga caacagaaag aaccagcuga aggacauggc caucgccacc      960

ggcggcgccg uguucggcga ggagggccug acccugaacc uggaggacgu gcagccccac     1020

gaccugggca aggugggcga ggugaucgug accaaggacg acgccaugcu gcugaagggc     1080

aagggcgaca aggcccagau cgagaagaga auccaggaga ucaucgagca gcuggacgug     1140

accaccagcg aguacgagaa gggcaagcug aacgagagac uggccaagcu gagcgacggc     1200

guggccgugc ugaagguggg cggcaccagc gacguggagg ugaacgagaa gaaggacaga     1260

gugaccgacg cccugaacgc caccagagcc gccguggagg agggcaucgu gcugggcggc     1320

ggcugcgccc ugcugagaug cauccccgcc cuggacagcc ugacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagaga acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg cagccugauc guggagaaga ucaugcagag cagcagcgag     1500

gugggcuacg acgccauggc cggcgacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg uggugagaac cgcccugcug gacgccgccg gcguggccag ccugcugacc     1620

accgccgagg ugguggugac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg cauguucuga                                      1710


<210>  7671
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP60__Homo_sapiens__ACE06961

<400>  7671
augcugagac uccccaccgu guuccggcag augcgcccug ucagcagagu ucuggccccg       60

caccuuacac gggcuuacgc caaggacgug aaauuuggcg cggaugcucg cgcccugaug      120

cuccaagggg uggaccugcu ugccgaugcu gucgccguga cgaugggacc caagggcaga      180

accguuauca uugagcaguc cugggggucu ccuaaaguga caaaggacgg agucaccgug      240

gcuaaaagca ucgaucugaa ggacaaguau aaaaacauug gcgccaagcu cguucaggau      300

guggcgaaua acacaaauga agaggccggg gacggaacca caaccgcuac gguccuggcc      360

cgguccaucg cuaaagaagg cuucgagaag auuucuaaag gcgccaaccc cguggaaauc      420

cgcagagggg ugaugcuggc ggucgaugcc guuaucgcug agcucaagaa gcagagcaaa      480

ccugugacca cacccgagga aauugcccaa guggcuacca ucuccgccaa uggagacaag      540

gagauuggca acaucauuuc ugaugccaug aaaaaggucg ggcggaaagg agugaucaca      600

guuaaggacg gcaaaacccu gaaugaugaa cuugagauua ucgaggggau gaaguuugac      660

cgcggauaca ucagcccuua uuucauuaac acguccaagg gccagaaaug cgaauuucag      720

gacgcuuacg ugcugcucag cgagaagaaa aucucuucca uucagagcau cgucccggcg      780

cuggaaauug ccaaugcuca uagaaagccc cuugugauca ucgccgagga uguugacggc      840

gaagcccugu cuacacucgu gcugaaccgg cugaaagucg ggcuccaagu ggucgcugug      900

aaggccccug gauucggcga uaaucgcaag aaccagcuga aagacauggc gauugcuacc      960

gggggagccg uuuuuggcga ggaggggcuu acacugaauc ucgaagaugu gcagccccac     1020

gaccugggaa aggucggcga ggugaucguu accaaagaug acgccaugcu ucugaagggc     1080

aaaggggaua aggcucagau ugaaaagaga auccaagaga uuaucgaaca gcucgacgug     1140

accacauccg aguaugagaa aggaaagcug aacgaacggc uggccaaacu cagcgauggc     1200

gucgcugugc ugaagguugg gggaacgucu gacguggagg ucaaugagaa aaaggaccgc     1260

gugaccgaug cccuuaacgc gacaagagcc gcuguggaag aaggcaucgu ccucgggggc     1320

ggaugugccc ugcugcggug cauuccugcu cuugacuccc ugacccccgc caacgaggau     1380

cagaagaucg gcauugagau cauuaaaaga acacucaaga ucccggcgau gaccauugcc     1440

aaaaaugcug ggguggaagg aagccugauc guugagaaga ucaugcaauc cucuagcgaa     1500

gugggcuacg acgccauggc uggggauuuc gucaacaugg uggagaaagg aauuaucgac     1560

ccuacgaagg uugugcgcac agcccugcuc gaugccgcug gcgucgcguc ccugcuuacc     1620

accgccgagg ugguugugac agaaauuccc aaagaggaaa aggacccugg gaugggcgcu     1680

augggaggca ugggaggggg cauguuuuga                                      1710


<210>  7672
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP60__Homo_sapiens__ACE06961

<400>  7672
augcuaaggu uaccaacagu auucagacaa augagaccag uaucaagagu ccuagcacca       60

cauuuaacac gagcauaugc aaaagaugua aaauucgggg cagaugcaag ggcauugaug      120

uuacaaggag ucgauuuacu agcggaugca guagcgguaa caaugggacc aaaaggaaga      180

acaguaauaa uagaacaaag uuggggauca ccuaaaguaa caaaagaugg aguaacagua      240

gcaaaaagua uagauuuaaa agacaaauau aaaaacauug gagcaaaacu agugcaagau      300

guagcaaaca auaccaauga agaagcagga gaugguacaa caacagcaac gguauuggcu      360

agaucaauag cgaaagaagg auuugaaaaa auaucaaaag gcgcaaaccc aguagagaua      420

agaaggggag uaaugcuagc aguagaugcg guaauagcag aacuaaaaaa acaaaguaaa      480

ccuguaacaa ccccugagga aauagcacaa guugcaacua uaucagcaaa cggcgacaaa      540

gaaauaggga auauuauaag ugaugcaaug aagaaaguag gaagaaaagg uguaauaaca      600

guaaaagaug ggaaaacacu gaaugaugaa cuagagauaa uagaaggaau gaaauucgau      660

aggggauaca uaagcccaua cuuuauuaau acaucaaaag gacagaaaug cgaauuucaa      720

gacgcauacg ucuuacuaag cgaaaaaaaa auaaguagca uacaaucaau uguaccagca      780

cuggagauag cgaacgcaca ucgaaaacca uuagugauua uagcugaaga uguggaugga      840

gaggcacuaa guacauuagu guuaaacagg uuaaaaguag gacuucaagu aguagccgua      900

aaagccccag gauucggaga uaauagaaaa aaucaauuga aagacauggc aauugcaaca      960

ggaggagcag uauuuggcga agaaggauua acacuaaacc uagaagaugu acagccacac     1020

gauuuaggga aaguaggaga aguaauagug acgaaagacg augcaauguu acuaaaagga     1080

aaaggggaua aagcucaaau agagaaaaga auacaagaga uaauugaaca auuagacgua     1140

acaacaagcg aauacgaaaa aggaaaauua aaugaaaggc uagcaaaauu aagcgaugga     1200

guggcagugc uaaaaguagg aggaacaagu gacgucgaag uaaaugaaaa gaaagauaga     1260

gugacagaug cguuaaacgc aacaagagca gcaguagagg aagggauagu acuagggggc     1320

ggaugugccc uacuaagaug cauuccggcu uuagacucau uaacaccagc uaaugaagau     1380

caaaaaaucg gaauagaaau aauaaaaaga acguuaaaaa uaccagcaau gacgauagca     1440

aagaaugcag ggguagaagg aucacuaaua guggaaaaaa uaaugcaaag uucaagugaa     1500

guaggauaug acgcaauggc uggggauuuc guaaauaugg uagagaaagg gauaauagau     1560

ccaacaaaag uaguucgaac cgcauuauua gaugcagcag ggguagcauc acuacuaaca     1620

acugcagaag uaguaguaac agaaauacca aaagaagaga aagaucccgg aaugggagcu     1680

augggaggga uggguggagg gauguucuaa                                      1710


<210>  7673
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__P10809

<400>  7673

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  7674
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__AAA60127

<400>  7674
augcuucggu uacccacagu cuuucgccag augagaccgg uguccagggu acuggcuccu       60

caucucacuc gggcuuaugc caaagaugua aaauuuggug cagaugcccg agccuuaaug      120

cuucaaggug uagaccuuuu agccgaugcu guggccguua caauggggcc aaagggaaga      180

acagugauua uugagcagag uuggggaagu cccaaaguaa caaaagaugg ugugacuguu      240

gcaaagucaa uugacuuaaa agauaaauac aagaacauug gagcuaaacu uguucaagau      300

guugccaaua acacaaauga agaagcuggg gauggcacua ccacugcuac uguacuggca      360

cgcucuauag ccaaggaagg cuucgagaag auuagcaaag gugcuaaucc aguggaaauc      420

aggagaggug ugauguuagc uguugaugcu guaauugcug aacuuaaaaa gcagucuaaa      480

ccugugacca ccccugaaga aauugcacag guugcuacga uuucugcaaa cggagacaaa      540

gaaauuggca auaucaucuc ugaugcaaug aaaaaaguug gaagaaaggg ugucaucaca      600

guaaaggaug gaaaaacacu gaaugaugaa uuagaaauua uugaaggcau gaaguuugau      660

cgaggcuaua uuucuccaua cuuuauuaau acaucaaaag gucagaaaug ugaauuccag      720

gaugccuaug uucuguugag ugaaaagaaa auuucuagua uccaguccau uguaccugcu      780

cuugaaauug ccaaugcuca ccguaagccu uuggucauaa ucgcugaaga uguugaugga      840

gaagcucuaa guacacucgu cuugaauagg cuaaagguug gucuucaggu uguggcaguc      900

aaggcuccag gguuugguga caauagaaag aaccagcuua aagauauggc uauugcuacu      960

gguggugcag uguuuggaga agagggauug acccugaauc uugaagacgu ucagccucau     1020

gacuuaggaa aaguuggaga ggucauugug accaaagacg augccaugcu cuuaaaagga     1080

aaaggugaca aggcucaaau ugaaaaacgu auucaagaaa ucauugagca guuagauguc     1140

acaacuagug aauaugaaaa ggaaaaacug aaugaacggc uugcaaaacu uucagaugga     1200

guggcugugc ugaagguugg ugggacaagu gauguugaag ugaaugaaaa gaaagacaga     1260

guuacagaug cccuuaaugc uacaagagcu gcuguugaag aaggcauugu uuugggaggg     1320

gguugugccc uccuucgaug cauuccagcc uuggacucau ugacuccagc uaaugaagau     1380

caaaaaauug guauagaaau uauuaaaaga acacucaaaa uuccagcaau gaccauugcu     1440

aagaaugcag guguugaagg aucuuugaua guugagaaaa uuaugcaaag uuccucagaa     1500

guugguuaug augcuauggc uggagauuuu gugaauaugg uggaaaaagg aaucauugac     1560

ccaacaaagg uugugagaac ugcuuuauug gaugcugcug guguggccuc ucuguuaacu     1620

acagcagaag uuguagucac agaaauuccu aaagaagaga aggacccugg aaugggugca     1680

auggguggaa ugggaggugg uaugggaggu ggcauguucu aa                        1722


<210>  7675
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP60__Homo_sapiens__AAA60127

<400>  7675
augcugcgcc uccccaccgu guuccggcag augcgcccgg ucagccgggu gcuggcgccc       60

caccugaccc gcgccuacgc caaggacgug aaguucgggg ccgacgcccg ggcccucaug      120

cugcaggggg ucgaccugcu cgccgacgcg guggccguga cgaugggccc caaggggcgc      180

accgucauca ucgagcaguc cuggggcagc cccaagguga ccaaggacgg ggugaccguc      240

gccaagucca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggcgaaca acacgaacga ggaggccggc gacgggacca ccaccgccac gguccucgcc      360

cggagcaucg ccaaggaggg cuucgagaag aucuccaagg gggcgaaccc gguggagauc      420

cgccggggcg ugaugcuggc cgucgacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag gucgcgacca ucuccgccaa cggggacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gccgcaaggg ggugaucacg      600

gucaaggacg gcaagacccu caacgacgag cuggagauca ucgaggggau gaaguucgac      660

cggggcuaca ucucccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcucuc cgagaagaag aucagcucca uccagagcau cgugccggcc      780

cuggagaucg cgaacgccca ccgcaagccc cuggucauca ucgccgagga cguggacggg      840

gaggcccucu ccacccuggu ccugaaccgg cucaaggugg gccuccaggu ggucgccgug      900

aaggcgcccg gguucggcga caaccgcaag aaccagcuga aggacauggc caucgccacc      960

gggggcgccg uguucggcga ggaggggcug acgcugaacc uggaggacgu ccagccccac     1020

gaccucggca agguggggga ggugaucguc accaaggacg acgcgaugcu gcugaagggc     1080

aagggggaca aggcccagau cgagaagcgg auccaggaga ucaucgagca gcucgacgug     1140

accacgagcg aguacgagaa ggagaagcug aacgagcgcc uggccaagcu cuccgacggc     1200

guggccgucc ugaagguggg cgggaccagc gacguggagg ucaacgagaa gaaggaccgg     1260

gugaccgacg cccugaacgc gacccgcgcc gccguggagg agggcaucgu ccucgggggc     1320

gggugcgccc ugcugcggug caucccggcc cucgacuccc ugacgcccgc gaacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg gagccucauc guggagaaga ucaugcagag cuccagcgag     1500

gucggcuacg acgccauggc gggggacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg ucgugcggac ggcccugcug gacgccgccg gcguggcguc ccuccugacc     1620

accgccgagg ucguggugac cgagaucccg aaggaggaga aggaccccgg gaugggcgcc     1680

augggcggga ugggcggggg caugggcggc gggauguucu ga                        1722


<210>  7676
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP60__Homo_sapiens__AAA60127

<400>  7676
augcuccgcc uccccaccgu cuuccgccag augcgccccg ucucccgcgu ccucgccccc       60

caccucaccc gcgccuacgc caaggacguc aaguucggcg ccgacgcccg cgcccucaug      120

cuccagggcg ucgaccuccu cgccgacgcc gucgccguca ccaugggccc caagggccgc      180

accgucauca ucgagcaguc cuggggcucc cccaagguca ccaaggacgg cgucaccguc      240

gccaagucca ucgaccucaa ggacaaguac aagaacaucg gcgccaagcu cguccaggac      300

gucgccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cguccucgcc      360

cgcuccaucg ccaaggaggg cuucgagaag aucuccaagg gcgccaaccc cgucgagauc      420

cgccgcggcg ucaugcucgc cgucgacgcc gucaucgccg agcucaagaa gcaguccaag      480

cccgucacca cccccgagga gaucgcccag gucgccacca ucuccgccaa cggcgacaag      540

gagaucggca acaucaucuc cgacgccaug aagaaggucg gccgcaaggg cgucaucacc      600

gucaaggacg gcaagacccu caacgacgag cucgagauca ucgagggcau gaaguucgac      660

cgcggcuaca ucucccccua cuucaucaac accuccaagg gccagaagug cgaguuccag      720

gacgccuacg uccuccucuc cgagaagaag aucuccucca uccaguccau cguccccgcc      780

cucgagaucg ccaacgccca ccgcaagccc cucgucauca ucgccgagga cgucgacggc      840

gaggcccucu ccacccucgu ccucaaccgc cucaaggucg gccuccaggu cgucgccguc      900

aaggcccccg gcuucggcga caaccgcaag aaccagcuca aggacauggc caucgccacc      960

ggcggcgccg ucuucggcga ggagggccuc acccucaacc ucgaggacgu ccagccccac     1020

gaccucggca aggucggcga ggucaucguc accaaggacg acgccaugcu ccucaagggc     1080

aagggcgaca aggcccagau cgagaagcgc auccaggaga ucaucgagca gcucgacguc     1140

accaccuccg aguacgagaa ggagaagcuc aacgagcgcc ucgccaagcu cuccgacggc     1200

gucgccgucc ucaaggucgg cggcaccucc gacgucgagg ucaacgagaa gaaggaccgc     1260

gucaccgacg cccucaacgc cacccgcgcc gccgucgagg agggcaucgu ccucggcggc     1320

ggcugcgccc uccuccgcug cauccccgcc cucgacuccc ucacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccucaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcgucgaggg cucccucauc gucgagaaga ucaugcaguc cuccuccgag     1500

gucggcuacg acgccauggc cggcgacuuc gucaacaugg ucgagaaggg caucaucgac     1560

cccaccaagg ucguccgcac cgcccuccuc gacgccgccg gcgucgccuc ccuccucacc     1620

accgccgagg ucgucgucac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7677
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP60__Homo_sapiens__AAA60127

<400>  7677
augcugagac uccccaccgu guucaggcag augcggccug ucagccgcgu ucuugcccca       60

caccugacac gagcuuacgc aaaggacgug aaauuuggcg ccgaugcgcg ugcuuugaug      120

uuacaagggg uagaccugcu agccgaugca guggccguca cuaugggacc gaaggguaga      180

acggugauca uugagcaguc cuggggcucu cccaaaguua ccaaggacgg ggugacaguc      240

gcuaaaucaa uagaucucaa ggacaaguau aaaaacaucg gagcaaagcu ggugcaggau      300

guagccaaua acacuaauga agaggcuggc gacgguacca caaccgccac uguucuugcg      360

aggaguauug caaaagaagg guucgagaag aucagcaaag gagccaaccc uguggaaauu      420

cggcgcggcg ucaugcuggc uguggaugcc gugaucgcag aguugaagaa gcaguccaaa      480

ccagucacaa cccccgagga aauagcucaa guugccacga ucucugcgaa uggcgacaag      540

gagauuggga acaucauuuc ggaugccaug aaaaaggugg gaagaaaagg uguaaucacu      600

gugaaggacg gcaaaacccu caaugaugaa cuggagauaa uugaggggau gaaguuugac      660

aggggauaca ucucaccuua uuucauuaac acaagcaagg gccagaaaug cgaauuucag      720

gacgcauacg uccugcucag ugagaagaaa aucuccucua uccagagcau ugugccagcu      780

uuagaaauag ccaaugcuca ucggaagccc cugguuauca uugccgagga uguggacggu      840

gaagcacuuu ccacuuuggu ccugaaccgc cuaaaagugg ggcuccaagu aguugccgug      900

aaggcuccug gauucggcga uaaucgaaag aaccagcuga aagacauggc gaucgcaacc      960

ggcggggccg ucuuuggaga ggagggucuu acacugaauu uggaagaugu gcagccacac     1020

gaccucggca aggucgggga ggugauaguu accaaagaug acgcuaugcu guuaaaggga     1080

aaaggcgaua aggcccagau ugaaaagaga auccaagaga ucauugaaca gcuggacgug     1140

acgacuucag aguaugagaa agaaaagcuc aacgagaggc uugcaaaacu gagugauggu     1200

guagccgucu ugaagguugg gggcacaagc gacguggaag ugaaugagaa aaaggaccgg     1260

gucaccgaug cucuaaacgc cacucgugca gcgguggaag agggaaucgu acugggcggg     1320

ggaugugcuc uccugcgcug cauuccggcc cuugacucuc ugacacccgc aaacgaggau     1380

cagaagauag guaucgaaau uaucaaaaga accuugaaga ucccugccau gacgauugcu     1440

aaaaaugccg gcguggaggg gucccucaua guugaaaaga ucaugcaauc aagcagugag     1500

gucggauacg acgcaauggc uggcgauuuc gugaacaugg uggagaaagg uauuaucgac     1560

ccaaccaagg ucguuaggac agcccuguua gaugcggccg ggguggcuuc ucugcuaacu     1620

accgcagaag ugguagucac agagauuccc aaagaagaga aggacccugg caugggagcc     1680

augggcggga ugggaggugg caugggaggg ggcauguuuu ga                        1722


<210>  7678
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP60__Homo_sapiens__AAA60127

<400>  7678
augcugagac ugcccaccgu guucagacag augagacccg ugagcagagu gcuggccccc       60

caccugacca gagccuacgc caaggacgug aaguucggcg ccgacgccag agcccugaug      120

cugcagggcg uggaccugcu ggccgacgcc guggccguga ccaugggccc caagggcaga      180

accgugauca ucgagcagag cuggggcagc cccaagguga ccaaggacgg cgugaccgug      240

gccaagagca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cgugcuggcc      360

agaagcaucg ccaaggaggg cuucgagaag aucagcaagg gcgccaaccc cguggagauc      420

agaagaggcg ugaugcuggc cguggacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag guggccacca ucagcgccaa cggcgacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gcagaaaggg cgugaucacc      600

gugaaggacg gcaagacccu gaacgacgag cuggagauca ucgagggcau gaaguucgac      660

agaggcuaca ucagccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcugag cgagaagaag aucagcagca uccagagcau cgugcccgcc      780

cuggagaucg ccaacgccca cagaaagccc cuggugauca ucgccgagga cguggacggc      840

gaggcccuga gcacccuggu gcugaacaga cugaaggugg gccugcaggu gguggccgug      900

aaggcccccg gcuucggcga caacagaaag aaccagcuga aggacauggc caucgccacc      960

ggcggcgccg uguucggcga ggagggccug acccugaacc uggaggacgu gcagccccac     1020

gaccugggca aggugggcga ggugaucgug accaaggacg acgccaugcu gcugaagggc     1080

aagggcgaca aggcccagau cgagaagaga auccaggaga ucaucgagca gcuggacgug     1140

accaccagcg aguacgagaa ggagaagcug aacgagagac uggccaagcu gagcgacggc     1200

guggccgugc ugaagguggg cggcaccagc gacguggagg ugaacgagaa gaaggacaga     1260

gugaccgacg cccugaacgc caccagagcc gccguggagg agggcaucgu gcugggcggc     1320

ggcugcgccc ugcugagaug cauccccgcc cuggacagcc ugacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagaga acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg cagccugauc guggagaaga ucaugcagag cagcagcgag     1500

gugggcuacg acgccauggc cggcgacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg uggugagaac cgcccugcug gacgccgccg gcguggccag ccugcugacc     1620

accgccgagg ugguggugac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7679
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP60__Homo_sapiens__AAA60127

<400>  7679
augcugagac uccccaccgu guuccggcag augcgcccug ucagcagagu ucuggccccg       60

caccuuacac gggcuuacgc caaggacgug aaauuuggcg cggaugcucg cgcccugaug      120

cuccaagggg uggaccugcu ugccgaugcu gucgccguga cgaugggacc caagggcaga      180

accguuauca uugagcaguc cugggggucu ccuaaaguga caaaggacgg agucaccgug      240

gcuaaaagca ucgaucugaa ggacaaguau aaaaacauug gcgccaagcu cguucaggau      300

guggcgaaua acacaaauga agaggccggg gacggaacca caaccgcuac gguccuggcc      360

cgguccaucg cuaaagaagg cuucgagaag auuucuaaag gcgccaaccc cguggaaauc      420

cgcagagggg ugaugcuggc ggucgaugcc guuaucgcug agcucaagaa gcagagcaaa      480

ccugugacca cacccgagga aauugcccaa guggcuacca ucuccgccaa uggagacaag      540

gagauuggca acaucauuuc ugaugccaug aaaaaggucg ggcggaaagg agugaucaca      600

guuaaggacg gcaaaacccu gaaugaugaa cuugagauua ucgaggggau gaaguuugac      660

cgcggauaca ucagcccuua uuucauuaac acguccaagg gccagaaaug cgaauuucag      720

gacgcuuacg ugcugcucag cgagaagaaa aucucuucca uucagagcau cgucccggcg      780

cuggaaauug ccaaugcuca uagaaagccc cuugugauca ucgccgagga uguugacggc      840

gaagcccugu cuacacucgu gcugaaccgg cugaaagucg ggcuccaagu ggucgcugug      900

aaggccccug gauucggcga uaaucgcaag aaccagcuga aagacauggc gauugcuacc      960

gggggagccg uuuuuggcga ggaggggcuu acacugaauc ucgaagaugu gcagccccac     1020

gaccugggaa aggucggcga ggugaucguu accaaagaug acgccaugcu ucugaagggc     1080

aaaggggaua aggcucagau ugaaaagaga auccaagaga uuaucgaaca gcucgacgug     1140

accacauccg aguaugagaa agaaaagcug aacgagcggc uggccaaacu cagcgaugga     1200

gucgcugugc ugaagguggg cgggacgucu gacguugaag ucaaugagaa aaaggaccgc     1260

gugaccgaug cccuuaacgc gacaagagcc gcuguggaag agggaaucgu ccugggcggg     1320

ggcugugccc uccugcggug cauuccugcu cuugacuccc ugacccccgc caacgaggau     1380

cagaagaucg gaauugaaau cauuaaaaga acacucaaga ucccggcgau gaccauugcc     1440

aaaaaugcug gcguggaggg gagccugauc guugaaaaga ucaugcaauc cucuagcgag     1500

gugggauacg acgccauggc uggcgauuuc gucaacaugg uggagaaagg gauuaucgac     1560

ccuacgaagg uugugcgcac agcccugcuc gaugccgcug gagucgcguc ccugcuuacc     1620

accgccgaag ugguugugac agagauuccc aaagaagaga aggacccugg caugggggcu     1680

augggcggaa ugggcggggg aaugggcggg ggaauguuuu ga                        1722


<210>  7680
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP60__Homo_sapiens__AAA60127

<400>  7680
auguuaagau uaccaacggu auucagacaa augagaccag uaaguagagu acuagcucca       60

caucuaacaa gagccuaugc aaaagacgua aaauuuggag cugaugcaag agcauuaaug      120

cuacaaggag uagaucuacu agcagaugca guugcaguua caaugggacc aaaaggaagg      180

acggucauaa uagaacaaag cuggggaucg ccaaaaguaa cgaaagaugg aguuacugua      240

gcaaaaagca uagaccuaaa agauaaauau aagaacauag gagcaaaauu aguacaagac      300

gucgcaaaua auacaaacga agaagcagga gacggaacaa caaccgcaac aguacuugca      360

aggucaauug caaaagaagg auuugaaaaa auaucaaaag gagcaaaucc cguagaaaua      420

agaagagggg uaaugcuagc aguagacgca guaauagcag aacugaaaaa acaaaguaaa      480

ccagugacua caccagaaga aauagcgcaa guagcuacaa uaagcgcuaa uggagacaaa      540

gaaauaggaa acauaauaag cgaugccaug aaaaagguag gaagaaaagg aguaauaaca      600

guuaaagaug gaaaaacacu uaaugaugaa cucgaaauaa uagaagggau gaaauuugau      660

agaggauaua uaagcccaua cuuuauaaac acaaguaaag gacaaaaaug cgaauuccag      720

gaugcauacg uguuacuaag cgagaaaaaa aucaguagca uucaaucaau uguaccagca      780

uuagagaucg caaaugcgca uagaaaacca cuaguaauaa uagcagaaga uguagacgga      840

gaagcauuaa guacauuagu uuuaaauaga cuaaaaguag gacuacaagu aguagcagua      900

aaagcaccag gauucggaga uaaucgaaaa aaucaacuua aagauauggc aauagcaaca      960

ggaggcgcug uguucggaga agaaggguua acuuugaauc uagaagaugu acaaccacau     1020

gaucuaggaa aaguaggaga aguaauagua acaaaagacg augcaaugcu cuuaaaagga     1080

aaaggagaua aggcgcaaau ugaaaaaaga auucaagaaa uaauagaaca acuagaugua     1140

acaacaagug aauaugagaa agagaaacug aacgaaagac uggcaaaacu gagugacggc     1200

gucgcaguac uaaaaguagg uggcacguca gauguagaag uaaacgaaaa aaaagauaga     1260

guaacagacg cguuaaaugc uacuagagcg gcaguugaag aagguauagu cuuaggugga     1320

ggaugcgcau uguuaagaug uauaccagca uuagauagcc uaacacccgc aaaugaagau     1380

caaaagauug gaauagaaau aauaaaaaga acucuaaaaa uaccagcaau gaccauagcg     1440

aaaaaugcag guguagaagg aagccuaaua guagaaaaaa uaaugcaauc aaguucagaa     1500

guaggauaug augcgauggc gggugacuuu guuaauaugg uagaaaaagg uauuauagac     1560

ccaacaaaag uaguaagaac agcauuacug gacgcagcag gaguagcaag ucuauuaaca     1620

acagcagaag uuguaguaac ugaaauaccu aaagaggaaa aagauccagg aaugggagca     1680

augggaggaa ugggcggugg aaugggagga ggaauguuuu aa                        1722


<210>  7681
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__Q0VDF9

<400>  7681

Met Ala Ala Ile Gly Val His Leu Gly Cys Thr Ser Ala Cys Val Ala 
1               5                   10                  15      


Val Tyr Lys Asp Gly Arg Ala Gly Val Val Ala Asn Asp Ala Gly Asp 
            20                  25                  30          


Arg Val Thr Pro Ala Val Val Ala Tyr Ser Glu Asn Glu Glu Ile Val 
        35                  40                  45              


Gly Leu Ala Ala Lys Gln Ser Arg Ile Arg Asn Ile Ser Asn Thr Val 
    50                  55                  60                  


Met Lys Val Lys Gln Ile Leu Gly Arg Ser Ser Ser Asp Pro Gln Ala 
65                  70                  75                  80  


Gln Lys Tyr Ile Ala Glu Ser Lys Cys Leu Val Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Leu Arg Tyr Glu Ile Asp Thr Gly Glu Glu Thr Lys Phe Val Asn 
            100                 105                 110         


Pro Glu Asp Val Ala Arg Leu Ile Phe Ser Lys Met Lys Glu Thr Ala 
        115                 120                 125             


His Ser Val Leu Gly Ser Asp Ala Asn Asp Val Val Ile Thr Val Pro 
    130                 135                 140                 


Phe Asp Phe Gly Glu Lys Gln Lys Asn Ala Leu Gly Glu Ala Ala Arg 
145                 150                 155                 160 


Ala Ala Gly Phe Asn Val Leu Arg Leu Ile His Glu Pro Ser Ala Ala 
                165                 170                 175     


Leu Leu Ala Tyr Gly Ile Gly Gln Asp Ser Pro Thr Gly Lys Ser Asn 
            180                 185                 190         


Ile Leu Val Phe Lys Leu Gly Gly Thr Ser Leu Ser Leu Ser Val Met 
        195                 200                 205             


Glu Val Asn Ser Gly Ile Tyr Arg Val Leu Ser Thr Asn Thr Asp Asp 
    210                 215                 220                 


Asn Ile Gly Gly Ala His Phe Thr Glu Thr Leu Ala Gln Tyr Leu Ala 
225                 230                 235                 240 


Ser Glu Phe Gln Arg Ser Phe Lys His Asp Val Arg Gly Asn Ala Arg 
                245                 250                 255     


Ala Met Met Lys Leu Thr Asn Ser Ala Glu Val Ala Lys His Ser Leu 
            260                 265                 270         


Ser Thr Leu Gly Ser Ala Asn Cys Phe Leu Asp Ser Leu Tyr Glu Gly 
        275                 280                 285             


Gln Asp Phe Asp Cys Asn Val Ser Arg Ala Arg Phe Glu Leu Leu Cys 
    290                 295                 300                 


Ser Pro Leu Phe Asn Lys Cys Ile Glu Ala Ile Arg Gly Leu Leu Asp 
305                 310                 315                 320 


Gln Asn Gly Phe Thr Ala Asp Asp Ile Asn Lys Val Val Leu Cys Gly 
                325                 330                 335     


Gly Ser Ser Arg Ile Pro Lys Leu Gln Gln Leu Ile Lys Asp Leu Phe 
            340                 345                 350         


Pro Ala Val Glu Leu Leu Asn Ser Ile Pro Pro Asp Glu Val Ile Pro 
        355                 360                 365             


Ile Gly Ala Ala Ile Glu Ala Gly Ile Leu Ile Gly Lys Glu Asn Leu 
    370                 375                 380                 


Leu Val Glu Asp Ser Leu Met Ile Glu Cys Ser Ala Arg Asp Ile Leu 
385                 390                 395                 400 


Val Lys Gly Val Asp Glu Ser Gly Ala Ser Arg Phe Thr Val Leu Phe 
                405                 410                 415     


Pro Ser Gly Thr Pro Leu Pro Ala Arg Arg Gln His Thr Leu Gln Ala 
            420                 425                 430         


Pro Gly Ser Ile Ser Ser Val Cys Leu Glu Leu Tyr Glu Ser Asp Gly 
        435                 440                 445             


Lys Asn Ser Ala Lys Glu Glu Thr Lys Phe Ala Gln Val Val Leu Gln 
    450                 455                 460                 


Asp Leu Asp Lys Lys Glu Asn Gly Leu Arg Asp Ile Leu Ala Val Leu 
465                 470                 475                 480 


Thr Met Lys Arg Asp Gly Ser Leu His Val Thr Cys Thr Asp Gln Glu 
                485                 490                 495     


Thr Gly Lys Cys Glu Ala Ile Ser Ile Glu Ile Ala Ser 
            500                 505                 


<210>  7682
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP60__Homo_sapiens__AAI19691

<400>  7682
auggcggcca ucggaguuca ccugggcugc accucagccu guguggccgu cuauaaggau       60

ggccgggcug gugugguugc aaaugaugcc ggugaccgag uuacuccagc uguuguugcu      120

uacucagaaa augaagagau uguuggauug gcagcaaaac aaaguagaau aagaaauauu      180

ucaaauacag uaaugaaagu aaagcagauc cugggcagaa gcuccaguga uccacaagcu      240

cagaaauaca ucgcggaaag uaaauguuua gucauugaaa aaaaugggaa auuacgauau      300

gaaauagaua cuggagaaga aacaaaauuu guuaacccag aagauguugc cagacugaua      360

uuuaguaaaa ugaaagaaac ggcacauucu guauugggcu cagaugcaaa ugauguaguu      420

auuacugucc cguuugauuu uggagaaaag caaaaaaaug cucuuggaga agcagcuaga      480

gcugcuggau uuaauguuuu gcgauuaauu cacgaaccgu cugcagcucu ucuugcuuau      540

ggaauuggac aagacucccc uacuggaaaa agcaauauuu ugguguuuaa gcuuggagga      600

acauccuuau cucucagcgu cauggaaguu aacaguggaa uauaucgggu ucuuucaaca      660

aacacugaug auaacaucgg uggugcacau uucacagaaa ccuuagcaca guaucuagcu      720

ucugaguucc aaagauccuu caaacaugau gugagaggaa augcgcgagc caugaugaaa      780

uuaacgaaca gugcugaagu agcgaaacau ucuuugucaa ccuugggaag ugccaacugu      840

uuucuugacu cauuauauga aggucaagau uuugauugca auguguccag agcaagauuu      900

gaacuucuuu guucuccacu uuuuaauaag uguauagaag caaucagagg acucuuagau      960

caaaauggau uuacagcaga ugauaucaac aagguugucc uuuguggagg gucuucucga     1020

aucccaaagc uacagcaacu gauuaaagau cuuuucccag cuguugagcu ucucaauucu     1080

aucccuccug augaagugau cccuauuggu gcagcuauag aagcaggaau ucuuauuggg     1140

aaagaaaacc uguuggugga agacucucuu augauagagu guucagccag agauauuuua     1200

guuaagggug uggacgaauc aggagccagu agauucacag ugcuguuucc aucagggacu     1260

ccuuugccag cucgaagaca acacacauug caagccccug gaagcauauc uucagugugc     1320

cuugaacucu augagucuga ugggaagaac ucugccaaag aggaaaccaa guuugcacag     1380

guuguacucc aggauuuaga uaaaaaagaa aauggauuac gugauauauu agcuguucuu     1440

acuaugaaaa gggauggauc uuuacaugug acaugcacag aucaagaaac uggaaaaugu     1500

gaagcaaucu cuauugagau agcaucuuag                                      1530


<210>  7683
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP60__Homo_sapiens__AAI19691

<400>  7683
auggccgcca ucggcgugca ccuggggugc accagcgcgu gcgucgccgu guacaaggac       60

ggccgcgccg ggguggucgc caacgacgcc ggcgaccggg ugacccccgc gguggucgcc      120

uacuccgaga acgaggagau cguggggcuc gccgccaagc agagccgcau ccggaacauc      180

uccaacacgg ugaugaaggu caagcagauc cugggccgca gcuccagcga cccgcaggcg      240

cagaaguaca ucgccgaguc caagugccug gugaucgaga agaacggcaa gcuccgguac      300

gagaucgaca ccggggagga gaccaaguuc gugaaccccg aggacgucgc ccgccugauc      360

uucagcaaga ugaaggagac cgcccacucc gugcugggca gcgacgccaa cgacgugguc      420

aucacggugc ccuucgacuu cggggagaag cagaagaacg cgcucggcga ggccgcccgg      480

gccgccgggu ucaacgugcu gcgccugauc cacgagcccu ccgcggcccu ccuggccuac      540

ggcaucggcc aggacagccc gaccgggaag uccaacaucc uggucuucaa gcucggcggg      600

accagccugu cccugagcgu gauggaggug aacuccggca ucuaccgggu ccucagcacc      660

aacacggacg acaacaucgg cggggcccac uucaccgaga cccuggccca guaccuggcg      720

uccgaguucc agcgcagcuu caagcacgac gugcggggca acgcccgcgc caugaugaag      780

cucaccaaca gcgccgaggu ggccaagcac ucccugagca cgcugggguc cgcgaacugc      840

uuccucgaca gccuguacga gggccaggac uucgacugca acgucucccg ggcccgcuuc      900

gagcugcucu gcagcccccu guucaacaag ugcaucgagg ccauccgggg gcugcucgac      960

cagaacggcu ucaccgccga cgacaucaac aagguggucc ugugcggcgg guccagccgc     1020

auccccaagc ugcagcagcu caucaaggac cuguuccccg cgguggagcu gcucaacucc     1080

aucccgcccg acgaggugau ccccaucggc gccgccaucg aggccgggau ccugaucggc     1140

aaggagaacc ugcucgucga ggacagccug augaucgagu gcuccgcccg ggacauccug     1200

gugaaggggg uggacgagag cggcgcgucc cgcuucaccg uccucuuccc cagcggcacc     1260

ccgcugcccg cccggcgcca gcacacgcug caggcccccg gguccaucag cuccgugugc     1320

cucgagcugu acgagagcga cggcaagaac uccgccaagg aggagaccaa guucgcccag     1380

gugguccugc aggaccucga caagaaggag aacgggcugc gggacauccu ggcggugcuc     1440

accaugaagc gcgacggcag ccugcacgug accugcacgg accaggagac cgggaagugc     1500

gaggccauca gcaucgagau cgccuccuga                                      1530


<210>  7684
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP60__Homo_sapiens__AAI19691

<400>  7684
auggccgcca ucggcgucca ccucggcugc accuccgccu gcgucgccgu cuacaaggac       60

ggccgcgccg gcgucgucgc caacgacgcc ggcgaccgcg ucacccccgc cgucgucgcc      120

uacuccgaga acgaggagau cgucggccuc gccgccaagc agucccgcau ccgcaacauc      180

uccaacaccg ucaugaaggu caagcagauc cucggccgcu ccuccuccga cccccaggcc      240

cagaaguaca ucgccgaguc caagugccuc gucaucgaga agaacggcaa gcuccgcuac      300

gagaucgaca ccggcgagga gaccaaguuc gucaaccccg aggacgucgc ccgccucauc      360

uucuccaaga ugaaggagac cgcccacucc guccucggcu ccgacgccaa cgacgucguc      420

aucaccgucc ccuucgacuu cggcgagaag cagaagaacg cccucggcga ggccgcccgc      480

gccgccggcu ucaacguccu ccgccucauc cacgagcccu ccgccgcccu ccucgccuac      540

ggcaucggcc aggacucccc caccggcaag uccaacaucc ucgucuucaa gcucggcggc      600

accucccucu cccucuccgu cauggagguc aacuccggca ucuaccgcgu ccucuccacc      660

aacaccgacg acaacaucgg cggcgcccac uucaccgaga cccucgccca guaccucgcc      720

uccgaguucc agcgcuccuu caagcacgac guccgcggca acgcccgcgc caugaugaag      780

cucaccaacu ccgccgaggu cgccaagcac ucccucucca cccucggcuc cgccaacugc      840

uuccucgacu cccucuacga gggccaggac uucgacugca acgucucccg cgcccgcuuc      900

gagcuccucu gcuccccccu cuucaacaag ugcaucgagg ccauccgcgg ccuccucgac      960

cagaacggcu ucaccgccga cgacaucaac aaggucgucc ucugcggcgg cuccucccgc     1020

auccccaagc uccagcagcu caucaaggac cucuuccccg ccgucgagcu ccucaacucc     1080

aucccccccg acgaggucau ccccaucggc gccgccaucg aggccggcau ccucaucggc     1140

aaggagaacc uccucgucga ggacucccuc augaucgagu gcuccgcccg cgacauccuc     1200

gucaagggcg ucgacgaguc cggcgccucc cgcuucaccg uccucuuccc cuccggcacc     1260

ccccuccccg cccgccgcca gcacacccuc caggcccccg gcuccaucuc cuccgucugc     1320

cucgagcucu acgaguccga cggcaagaac uccgccaagg aggagaccaa guucgcccag     1380

gucguccucc aggaccucga caagaaggag aacggccucc gcgacauccu cgccguccuc     1440

accaugaagc gcgacggcuc ccuccacguc accugcaccg accaggagac cggcaagugc     1500

gaggccaucu ccaucgagau cgccuccuga                                      1530


<210>  7685
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP60__Homo_sapiens__AAI19691

<400>  7685
auggccgcua ucggcgugca ccuggggugc accagcgcau gugucgccgu uuacaaggac       60

gguagagcgg gagugguagc uaacgaugcc ggcgacaggg ugacacccgc agucguggcc      120

uauuccgaga augaagagau uguugggcuc gcugcaaaac agucucggau acgcaacauc      180

ucaaauacug ugaugaaggu caaacaaauu cuuggacgaa guagcuccga uccucaggcc      240

cagaaguaca ucgcugaauc uaaaugccug gugauugaga agaacggcaa guugcguuau      300

gaaaucgaca cgggugagga gaccaaauuc guaaauccag aagauguugc cagauuaaua      360

uuuucgaaga ugaaagagac agcgcauuca gugcugggga gcgacgcaaa cgaugucgug      420

aucacugugc cguucgacuu uggagaaaag cagaaaaaug cccuaggcga ggcugccagg      480

gcagcuggcu ucaacguccu ccggcugauu cacgagccca gugccgcgcu ucuggccuac      540

gggaucggac aagauucccc uaccgguaag ucuaauauuu ugguuuuuaa gcucggcggg      600

acaagccugu cccugucagu gauggaagua aacaguggaa ucuaucgcgu gcucagcacc      660

aauacugacg auaacauagg cggugcacau uucacagaga ccuuagcuca guaccuggcc      720

ucugaauuuc agagauccuu caaacacgac gucaggggga augcucgggc caugaugaag      780

cugacgaacu cagcagaggu ggccaaacau agcuugagua cucugggauc ugcuaauugu      840

uuucuagauu cccucuauga aggccaggac uucgacugca acguuagccg cgcgcgauuu      900

gagcugcuuu guucgccacu guucaacaag ugcauugagg caaucagagg cuugcucgau      960

caaaaugggu uuaccgccga cgauauuaac aaaguggucc uguguggagg uucuuccagg     1020

auccccaagu uacagcagcu gaucaaagac cucuucccug cuguggaacu ucuuaauuca     1080

auuccacccg augagguaau accuaucggc gccgcaauug aagccgggau cuugauagga     1140

aaggagaacc uacugguuga agacagucuc augauugagu gcagcgcucg ggauauccug     1200

gugaagggcg ucgacgaguc cggugccucu cguuucacag ugcuuuuucc aagcgggacu     1260

ccgcugcccg cacgcagaca gcacaccuug caagcgccug gcucaaucag uuccgucugu     1320

cucgaacugu acgagagcga uggcaaaaau ucugcuaagg aagagacaaa auucgcccag     1380

gugguuuuac aggaccugga uaagaaagaa aacggacuaa gggacauucu cgcagugcug     1440

accaugaagc gggacggguc acuucacgua acgugcacug aucaagagac aggaaagugu     1500

gaggccauca guauugaaau agcuagcuga                                      1530


<210>  7686
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP60__Homo_sapiens__AAI19691

<400>  7686
auggccgcca ucggcgugca ccugggcugc accagcgccu gcguggccgu guacaaggac       60

ggcagagccg gcgugguggc caacgacgcc ggcgacagag ugacccccgc cgugguggcc      120

uacagcgaga acgaggagau cgugggccug gccgccaagc agagcagaau cagaaacauc      180

agcaacaccg ugaugaaggu gaagcagauc cugggcagaa gcagcagcga cccccaggcc      240

cagaaguaca ucgccgagag caagugccug gugaucgaga agaacggcaa gcugagauac      300

gagaucgaca ccggcgagga gaccaaguuc gugaaccccg aggacguggc cagacugauc      360

uucagcaaga ugaaggagac cgcccacagc gugcugggca gcgacgccaa cgacguggug      420

aucaccgugc ccuucgacuu cggcgagaag cagaagaacg cccugggcga ggccgccaga      480

gccgccggcu ucaacgugcu gagacugauc cacgagccca gcgccgcccu gcuggccuac      540

ggcaucggcc aggacagccc caccggcaag agcaacaucc ugguguucaa gcugggcggc      600

accagccuga gccugagcgu gauggaggug aacagcggca ucuacagagu gcugagcacc      660

aacaccgacg acaacaucgg cggcgcccac uucaccgaga cccuggccca guaccuggcc      720

agcgaguucc agagaagcuu caagcacgac gugagaggca acgccagagc caugaugaag      780

cugaccaaca gcgccgaggu ggccaagcac agccugagca cccugggcag cgccaacugc      840

uuccuggaca gccuguacga gggccaggac uucgacugca acgugagcag agccagauuc      900

gagcugcugu gcagcccccu guucaacaag ugcaucgagg ccaucagagg ccugcuggac      960

cagaacggcu ucaccgccga cgacaucaac aagguggugc ugugcggcgg cagcagcaga     1020

auccccaagc ugcagcagcu gaucaaggac cuguuccccg ccguggagcu gcugaacagc     1080

aucccccccg acgaggugau ccccaucggc gccgccaucg aggccggcau ccugaucggc     1140

aaggagaacc ugcuggugga ggacagccug augaucgagu gcagcgccag agacauccug     1200

gugaagggcg uggacgagag cggcgccagc agauucaccg ugcuguuccc cagcggcacc     1260

ccccugcccg ccagaagaca gcacacccug caggcccccg gcagcaucag cagcgugugc     1320

cuggagcugu acgagagcga cggcaagaac agcgccaagg aggagaccaa guucgcccag     1380

guggugcugc aggaccugga caagaaggag aacggccuga gagacauccu ggccgugcug     1440

accaugaaga gagacggcag ccugcacgug accugcaccg accaggagac cggcaagugc     1500

gaggccauca gcaucgagau cgccagcuga                                      1530


<210>  7687
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP60__Homo_sapiens__AAI19691

<400>  7687
auggccgcua ucggcgucca ccuggggugc accagcgccu gugucgcggu uuacaaggac       60

ggcagagcug gagugguggc caacgaugcc ggggaccggg ucacacccgc ugugguugcc      120

uauuccgaga augaagagau ugugggacuc gcugccaaac agucucgcau cagaaacauu      180

agcaauacgg ucaugaaggu gaaacaaauc cugggccggu ccucuagcga uccucaggcg      240

cagaaguaca uugccgaauc caaaugccuu guuaucgaga agaacgggaa gcugcgcuau      300

gaaaucgaca ccggagagga gacaaaauuc gugaauccgg aagaugucgc uagacucauc      360

uuuucuaaga ugaaagagac cgcccauagc gugcugggcu ccgacgcuaa cgaugugguc      420

auuacaguuc ccuucgacuu uggcgaaaag cagaaaaaug cccuugggga ggcggcccgg      480

gcugccggau ucaacgugcu gcgccucauu cacgagccua gcgcugcccu gcuggccuac      540

ggcaucgggc aagauucucc caccggaaag uccaauauuc ucguguuuaa gcugggcggg      600

acaagccuuu cucuguccgu cauggaagug aacagcggaa ucuauagagu ucucucuacc      660

aauacggacg auaacauugg cggcgcucau uucaccgaga cacuggcgca guaccuugcc      720

uccgaauuuc agcggagcuu caaacacgac gugcgcggga augcuagagc caugaugaag      780

cugaccaacu ccgccgaggu cgcuaaacau ucucucagca cacugggauc cgccaauugu      840

uuucuggaua gccucuauga aggccaggac uucgacugca acgugucucg ggcgcgcuuu      900

gagcugcuuu guuccccucu guucaacaag ugcaucgagg cuaucagagg gcuccuggau      960

caaaauggau uuaccgccga cgauauuaac aaaguugugc uuuguggcgg gagcucucgg     1020

auccccaagc ugcagcagcu cauuaaagac cuguucccug ccgucgaacu gcucaauagc     1080

aucccgcccg augaggugau uccuaucgga gcugccaucg aagcuggcau ucugaucggc     1140

aaggagaacc uucuggucga agacucccuc augauugagu gcucugcccg cgauauccug     1200

gugaaggggg uugacgagag cggagcgucc agauucacgg ugcuuuuucc cagcggcaca     1260

ccucugcccg cccggagaca gcacacccuc caagcuccgg ggucuauuuc cagcgucugu     1320

cuggaacugu acgagucuga uggcaaaaau uccgccaagg aagagacaaa auucgcucag     1380

gugguucucc aggaccugga uaagaaagaa aacggacuuc gcgacauccu ggccgugcuc     1440

accaugaagc gggacgggag ccugcacgug accugcacag aucaagagac gggcaagugu     1500

gaggcgaucu ccauugaaau cgccucuuga                                      1530


<210>  7688
<211>  1530
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP60__Homo_sapiens__AAI19691

<400>  7688
auggcagcaa uaggaguaca ucuagguugu acaucagcau gcguagcagu uuacaaagau       60

ggaagagcag gaguaguagc aaacgacgca ggugauagag uaacaccagc gguuguagcc      120

uauucagaaa augaagaaau aguaggauua gcugcaaaac aaucaagaau aagaaauaua      180

aguaacacag uaaugaaagu aaaacaaaua cuaggaagaa guaguagcga cccacaagca      240

caaaaauaua uagcagaaag uaaauguuua gucauagaaa aaaauggaaa acucagauac      300

gaaauagaua caggagaaga aacaaaauuu guaaaucccg aagacguugc aagacuaaua      360

uucagcaaaa ugaaagaaac ugcucauuca guacuaggau cagaugcaaa ugauguagua      420

auaacaguac cauuugauuu uggagaaaaa caaaaaaaug cauuaggaga agcagcaaga      480

gcagccggau uuaauguauu aagauuaaua cacgaaccau cugcagcauu acuagcauau      540

gggauuggac aagauucacc aacuggaaag agcaacauac uaguauucaa acuugguggg      600

acuagucuau cguuaagugu aauggaaguc aacagcggaa uuuacagagu acuaucaaca      660

aauacggacg acaacauagg uggagcacac uuuacagaaa cacuagcaca guacuuagca      720

uccgaauuuc aaagguccuu caaacaugac guaaggggaa augcaagagc caugaugaaa      780

uuaacaaaua gcgcagaagu agcaaaacau ucauuaucaa cauuaggauc ugccaauugc      840

uuucuggaua guuuauacga aggacaagac uucgacugca auguuaguag agcuagauuu      900

gaauuauuau guagcccauu auucaauaaa uguauagaag caauacgagg acuacuagac      960

caaaauggau ucacagcaga ugacauaaac aagguuguau uauguggagg aaguucacga     1020

auaccaaaau uacaacaacu aauuaaagac cuauucccag caguagagcu auugaauagc     1080

auaccacccg acgaaguaau accaauugga gcagcuauag aagcaggaau auuaauagga     1140

aaagaaaacu uauuaguaga agacagccua augauagaau gcagcgcuag agacauauua     1200

guuaaaggcg uugaugaaag cggagcaucu agauuuacag uacucuuccc aagcggaaca     1260

ccccuaccag caagaagaca acacacauua caagccccag gaucaauauc aaguguaugc     1320

cuugaacuuu acgaaucaga uggaaaaaac agugcaaagg aagagacaaa auuugcacaa     1380

guaguacuac aagaucuaga caaaaaagaa aauggccuaa gagauauauu agcaguacua     1440

acaaugaaga gagacggaag ccuacaugua accugcaccg aucaagaaac aggaaaaugc     1500

gaagcaauau caauagaaau agcaucauaa                                      1530


<210>  7689
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP70__Homo_sapiens__P38646

<400>  7689

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  7690
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP70__Homo_sapiens__ABF50973

<400>  7690
augauaagug ccagccgagc ugcagcagcc cgucucgugg gcgccgcagc cucccggggc       60

ccuacggccg cccgccacca ggauagcugg aauggccuua gucaugaggc uuuuagacuu      120

guuucaaggc gggauuaugc aucagaagca aucaagggag caguuguugg uauugauuug      180

gguacuacca acuccugcgu ggcaguuaug gaagguaaac aagcaaaggu gcuggagaau      240

gccgaaggug ccagaaccac cccuucaguu guggccuuua cagcagaugg ugagcgacuu      300

guuggaaugc cggccaagcg acaggcuguc accaacccaa acaauacauu uuaugcuacc      360

aagcgucuca uuggccggcg auaugaugau ccugaaguac agaaagacau uaaaaauguu      420

cccuuuaaaa uuguccgugc cuccaauggu gaugccuggg uugaggcuca ugggaaauug      480

uauucuccga gucagauugg agcauuugug uugaugaaga ugaaagagac ugcagaaaau      540

uacuuggggc acacagcaaa aaaugcugug aucacagucc cagcuuauuu caaugacucg      600

cagagacagg ccacuaaaga ugcuggccag auaucuggac ugaaugugcu ucgggugauu      660

aaugagccca cagcugcugc ucuugccuau ggucuagaca aaucagaaga caaagucauu      720

gcuguauaug auuuaggugg uggaacuuuu gauauuucua uccuggaaau ucagaaagga      780

guauuugagg ugaaauccac aaauggggau accuucuuag guggggaaga cuuugaccag      840

gccuugcuac ggcacauugu gaaggaguuc aagagagaga cagggguuga uuugacuaaa      900

gacaacaugg cacuucagag gguacgggaa gcugcugaaa aggcuaaaug ugaacucucc      960

ucaucugugc agacugacau caauuugccc uaucuuacaa uggauucuuc uggacccaag     1020

cauuugaaua ugaaguugac ccgugcucaa uuugaaggga uugucacuga ucuaaucaga     1080

aggacuaucg cuccaugcca aaaagcuaug caagaugcag aagucagcaa gagugacaua     1140

ggagaaguga uucuuguggg uggcaugacu aggaugccca agguucagca gacuguacag     1200

gaucuuuuug gcagagcccc aaguaaagcu gucaauccug augaggcugu ggccauugga     1260

gcugccauuc agggaggugu guuggccggc gaugucacgg augugcugcu ccuugauguc     1320

acuccccugu cucuggguau ugaaacucua ggaggugucu uuaccaaacu uauuaauagg     1380

aauaccacua uuccaaccaa gaagagccag guauucucua cugccgcuga uggucaaacg     1440

caaguggaaa uuaaagugug ucagggugaa agagagaugg cuggagacaa caaacuccuu     1500

ggacaguuua cuuugauugg aauuccacca gccccucgug gaguuccuca gauugaaguu     1560

acauuugaca uugaugccaa ugggauagua cauguuucug cuaaagauaa aggcacagga     1620

cgugagcagc agauuguaau ccagucuucu gguggauuaa gcaaagauga uauugaaaau     1680

augguuaaaa augcagagaa auaugcugaa gaagaccggc gaaagaagga acgaguugaa     1740

gcaguuaaua uggcugaagg aaucauucac gacacagaaa ccaagaugga agaauucaag     1800

gaccaauuac cugcugauga gugcaacaag cugaaagaag agauuuccaa aaugagggag     1860

cuccuggcua gaaaagacag cgaaacagga gaaaauauua gacaggcagc auccucucuu     1920

cagcaggcau cauugaagcu guucgaaaug gcauacaaaa agauggcauc ugagcgagaa     1980

ggcucuggaa guucuggcac uggggaacaa aaggaagauc aaaaggagga aaaacaguaa     2040


<210>  7691
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP70__Homo_sapiens__ABF50973

<400>  7691
augaucagcg ccucccgcgc cgcggccgcc cggcuggugg gcgccgccgc gagccgcggg       60

cccaccgccg cccggcacca ggacuccugg aacggccuca gccacgaggc cuuccgccug      120

gucucccggc gcgacuacgc gagcgaggcc aucaaggggg ccgugguggg caucgaccug      180

gggaccacga acuccugcgu cgccgugaug gagggcaagc aggccaaggu gcucgagaac      240

gcggagggcg cccggaccac cccgagcguc guggccuuca ccgccgacgg ggagcgccug      300

gugggcaugc ccgccaagcg gcaggcgguc acgaacccca acaacaccuu cuacgccacc      360

aagcgccuga ucgggcggcg cuacgacgac cccgaggugc agaaggacau caagaacgug      420

ccguucaaga ucguccgggc cuccaacggc gacgccuggg uggaggccca cgggaagcuc      480

uacagccccu cccagaucgg cgcguucgug cugaugaaga ugaaggagac cgccgagaac      540

uaccugggcc acacggccaa gaacgccguc aucaccgugc ccgccuacuu caacgacagc      600

cagcgccagg cgaccaagga cgccgggcag aucuccggcc ucaacgugcu gcgggucauc      660

aacgagccca ccgccgccgc gcuggccuac gggcucgaca agagcgagga caaggugauc      720

gccguguacg accugggcgg cgggacguuc gacaucucca uccuggagau ccagaagggc      780

gucuucgagg ucaagagcac caacggggac accuuccucg gcggggagga cuucgaccag      840

gcccugcugc gccacaucgu gaaggaguuc aagcgggaga ccggcgugga ccucacgaag      900

gacaacaugg cccugcagcg cgugcgggag gcggccgaga aggccaagug cgagcugucc      960

agcuccgucc agaccgacau caaccucccg uaccugacca uggacagcag cggccccaag     1020

caccugaaca ugaagcucac ccgcgcccag uucgagggga ucgugacgga ccugauccgg     1080

cgcaccaucg cccccugcca gaaggcgaug caggacgccg agguguccaa gagcgacauc     1140

ggcgagguca uccuggucgg gggcaugacc cgcaugccca aggugcagca gaccgugcag     1200

gaccucuucg ggcgggcccc guccaaggcc gugaaccccg acgaggccgu ggcgaucggc     1260

gccgccaucc agggcggggu ccuggccggc gacgugacgg acgugcugcu ccuggacguc     1320

acgccccuga gccucgggau cgagacccug ggcggggugu ucaccaagcu gaucaaccgc     1380

aacaccacca uccccaccaa gaagucccag guguucagca ccgcggccga cggccagacg     1440

caggucgaga ucaaggugug ccagggcgag cgggagaugg ccggggacaa caagcuccug     1500

ggccaguuca cccugaucgg gaucccgccc gcgccccgcg gcgugcccca gaucgagguc     1560

accuucgaca ucgacgccaa cggcaucgug cacguguccg ccaaggacaa ggggaccggc     1620

cgggagcagc agaucgucau ccagagcucc gggggccuca gcaaggacga caucgagaac     1680

auggugaaga acgccgagaa guacgccgag gaggaccgcc ggaagaagga gcgcguggag     1740

gccgucaaca uggccgaggg gaucauccac gacacggaga ccaagaugga ggaguucaag     1800

gaccagcugc cggcggacga gugcaacaag cugaaggagg agaucuccaa gaugcgggag     1860

cuccuggccc gcaaggacag cgagaccggc gagaacaucc ggcaggccgc cuccagccug     1920

cagcaggccu cccucaagcu guucgagaug gcguacaaga agauggccag cgagcgcgag     1980

ggcuccggga gcuccggcac cggggagcag aaggaggacc agaaggagga gaagcaguga     2040


<210>  7692
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP70__Homo_sapiens__ABF50973

<400>  7692
augaucuccg ccucccgcgc cgccgccgcc cgccucgucg gcgccgccgc cucccgcggc       60

cccaccgccg cccgccacca ggacuccugg aacggccucu cccacgaggc cuuccgccuc      120

gucucccgcc gcgacuacgc cuccgaggcc aucaagggcg ccgucgucgg caucgaccuc      180

ggcaccacca acuccugcgu cgccgucaug gagggcaagc aggccaaggu ccucgagaac      240

gccgagggcg cccgcaccac ccccuccguc gucgccuuca ccgccgacgg cgagcgccuc      300

gucggcaugc ccgccaagcg ccaggccguc accaacccca acaacaccuu cuacgccacc      360

aagcgccuca ucggccgccg cuacgacgac cccgaggucc agaaggacau caagaacguc      420

cccuucaaga ucguccgcgc cuccaacggc gacgccuggg ucgaggccca cggcaagcuc      480

uacucccccu cccagaucgg cgccuucguc cucaugaaga ugaaggagac cgccgagaac      540

uaccucggcc acaccgccaa gaacgccguc aucaccgucc ccgccuacuu caacgacucc      600

cagcgccagg ccaccaagga cgccggccag aucuccggcc ucaacguccu ccgcgucauc      660

aacgagccca ccgccgccgc ccucgccuac ggccucgaca aguccgagga caaggucauc      720

gccgucuacg accucggcgg cggcaccuuc gacaucucca uccucgagau ccagaagggc      780

gucuucgagg ucaaguccac caacggcgac accuuccucg gcggcgagga cuucgaccag      840

gcccuccucc gccacaucgu caaggaguuc aagcgcgaga ccggcgucga ccucaccaag      900

gacaacaugg cccuccagcg cguccgcgag gccgccgaga aggccaagug cgagcucucc      960

uccuccgucc agaccgacau caaccucccc uaccucacca uggacuccuc cggccccaag     1020

caccucaaca ugaagcucac ccgcgcccag uucgagggca ucgucaccga ccucauccgc     1080

cgcaccaucg cccccugcca gaaggccaug caggacgccg aggucuccaa guccgacauc     1140

ggcgagguca uccucgucgg cggcaugacc cgcaugccca agguccagca gaccguccag     1200

gaccucuucg gccgcgcccc cuccaaggcc gucaaccccg acgaggccgu cgccaucggc     1260

gccgccaucc agggcggcgu ccucgccggc gacgucaccg acguccuccu ccucgacguc     1320

accccccucu cccucggcau cgagacccuc ggcggcgucu ucaccaagcu caucaaccgc     1380

aacaccacca uccccaccaa gaagucccag gucuucucca ccgccgccga cggccagacc     1440

caggucgaga ucaaggucug ccagggcgag cgcgagaugg ccggcgacaa caagcuccuc     1500

ggccaguuca cccucaucgg cauccccccc gccccccgcg gcguccccca gaucgagguc     1560

accuucgaca ucgacgccaa cggcaucguc cacgucuccg ccaaggacaa gggcaccggc     1620

cgcgagcagc agaucgucau ccaguccucc ggcggccucu ccaaggacga caucgagaac     1680

auggucaaga acgccgagaa guacgccgag gaggaccgcc gcaagaagga gcgcgucgag     1740

gccgucaaca uggccgaggg caucauccac gacaccgaga ccaagaugga ggaguucaag     1800

gaccagcucc ccgccgacga gugcaacaag cucaaggagg agaucuccaa gaugcgcgag     1860

cuccucgccc gcaaggacuc cgagaccggc gagaacaucc gccaggccgc cuccucccuc     1920

cagcaggccu cccucaagcu cuucgagaug gccuacaaga agauggccuc cgagcgcgag     1980

ggcuccggcu ccuccggcac cggcgagcag aaggaggacc agaaggagga gaagcaguga     2040


<210>  7693
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP70__Homo_sapiens__ABF50973

<400>  7693
augaucagcg ccuccagagc ugcagccgcg aggcuggugg gcgcugccgc aucucggggg       60

cccaccgccg cucgccacca ggacucaugg aacggacuca gucaugaggc auuccgacuu      120

gucagccgua gagauuacgc cuccgaagcu auuaagggug ccguuguggg cauagaccug      180

gggacaacua auucuugcgu agcggugaug gagggaaaac aagcaaaggu cuuggaaaac      240

gccgagggcg cuaggacgac cccuucggug guugccuuua cagcagaugg ugaacgguua      300

guggggaugc cagcuaaacg ccaggccguc acuaauccga acaauaccuu cuaugcgaca      360

aagagacuga ucggaaggcg guacgacgau cccgaggugc agaaagacau uaagaacgua      420

ccuuuuaaga ucguucgcgc cucaaauggc gaugcauggg uggaggcuca cggcaaacua      480

uauagcccaa gucagauugg ggccuucguc cucaugaaga ugaaagaaac cgcugagaac      540

uaccugggac auacugccaa gaaugcagug aucacagugc ccgccuauuu uaacgacucc      600

caacgacagg cuaccaaaga ugcgggucag auaucuggcc uuaauguccu gagaguuauc      660

aacgaaccua cggcagccgc uuuggccuac gggcucgaca agagcgagga uaaggugauu      720

gcaguauaug accugggagg cgguacuuuc gauaucucca uucuggagau ccagaaaggg      780

guguuugaag ucaagucaac caauggagac acauuccucg gcggcgagga cuuugaucaa      840

gccuuacuga ggcacauagu gaaagaguuc aagcgggaaa cugggguuga ccuuaccaaa      900

gauaacaugg cuuugcagcg ugugcgcgaa gccgcagaga aggcgaaaug ugagcugagu      960

agcucugucc agacagacau uaaucuacca uaccucacca uggauuccuc aggacccaag     1020

caucugaaca ugaaguugac gagagcucag uuugaaggua ucgugacuga ccugauuagg     1080

cggacaaucg ccccuugcca aaaagcaaug caggaugccg agguaagcaa gagugacauc     1140

ggcgaaguua uuuuggucgg gggaaugacc cgaaugccaa aagugcagca aacugugcag     1200

gaucucuucg gccgcgcucc gucuaaggcc gucaaccccg acgaggcagu ggcuauaggu     1260

gccgcgaucc aagggggcgu ucuggccgga gaugugacag acguauuacu gcucgacguc     1320

accccucuuu cccugggcau ugaaacgcuu gggggagugu uuaccaaacu aaucaauaga     1380

aacacaacua uaccaaccaa aaagagccag guuuucucga cagcugcaga uggucagacu     1440

cagguggaga uuaaggucug ucagggcgag agggaaaugg ccggggacaa uaagcugcuc     1500

ggacaguuca cccugaucgg cauucccccu gcuccacggg gugugcccca aaucgaggua     1560

acauuugaua ucgacgccaa cgggauugug cacguuucug caaaagauaa gggcaccgga     1620

cgcgaacagc agauagucau ccaguccuca ggcgggcuua guaaagacga uauugagaau     1680

auggugaaga acgcggaaaa guacgccgag gaggacagaa ggaaaaagga acguguggag     1740

gcugucaaua uggccgaagg aaucauccac gauacugaga cgaaaaugga ggaguucaag     1800

gaccaacugc cggcagauga augcaacaaa uugaaggaag agauuagcaa gaugcgggaa     1860

cuccuggcuc gaaaagacuc cgagacaggu gagaauauaa gacaggccgc aucuagcuua     1920

cagcaggccu cacugaagcu auuugaaaug gcuuauaaaa agauggcgag ugagagggaa     1980

ggcuccggga gcucuggaac cggcgagcaa aaagaagauc agaaggagga gaaacaguga     2040


<210>  7694
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP70__Homo_sapiens__ABF50973

<400>  7694
augaucagcg ccagcagagc cgccgccgcc agacuggugg gcgccgccgc cagcagaggc       60

cccaccgccg ccagacacca ggacagcugg aacggccuga gccacgaggc cuucagacug      120

gugagcagaa gagacuacgc cagcgaggcc aucaagggcg ccgugguggg caucgaccug      180

ggcaccacca acagcugcgu ggccgugaug gagggcaagc aggccaaggu gcuggagaac      240

gccgagggcg ccagaaccac ccccagcgug guggccuuca ccgccgacgg cgagagacug      300

gugggcaugc ccgccaagag acaggccgug accaacccca acaacaccuu cuacgccacc      360

aagagacuga ucggcagaag auacgacgac cccgaggugc agaaggacau caagaacgug      420

cccuucaaga ucgugagagc cagcaacggc gacgccuggg uggaggccca cggcaagcug      480

uacagcccca gccagaucgg cgccuucgug cugaugaaga ugaaggagac cgccgagaac      540

uaccugggcc acaccgccaa gaacgccgug aucaccgugc ccgccuacuu caacgacagc      600

cagagacagg ccaccaagga cgccggccag aucagcggcc ugaacgugcu gagagugauc      660

aacgagccca ccgccgccgc ccuggccuac ggccuggaca agagcgagga caaggugauc      720

gccguguacg accugggcgg cggcaccuuc gacaucagca uccuggagau ccagaagggc      780

guguucgagg ugaagagcac caacggcgac accuuccugg gcggcgagga cuucgaccag      840

gcccugcuga gacacaucgu gaaggaguuc aagagagaga ccggcgugga ccugaccaag      900

gacaacaugg cccugcagag agugagagag gccgccgaga aggccaagug cgagcugagc      960

agcagcgugc agaccgacau caaccugccc uaccugacca uggacagcag cggccccaag     1020

caccugaaca ugaagcugac cagagcccag uucgagggca ucgugaccga ccugaucaga     1080

agaaccaucg cccccugcca gaaggccaug caggacgccg aggugagcaa gagcgacauc     1140

ggcgagguga uccugguggg cggcaugacc agaaugccca aggugcagca gaccgugcag     1200

gaccuguucg gcagagcccc cagcaaggcc gugaaccccg acgaggccgu ggccaucggc     1260

gccgccaucc agggcggcgu gcuggccggc gacgugaccg acgugcugcu gcuggacgug     1320

accccccuga gccugggcau cgagacccug ggcggcgugu ucaccaagcu gaucaacaga     1380

aacaccacca uccccaccaa gaagagccag guguucagca ccgccgccga cggccagacc     1440

cagguggaga ucaaggugug ccagggcgag agagagaugg ccggcgacaa caagcugcug     1500

ggccaguuca cccugaucgg cauccccccc gcccccagag gcgugcccca gaucgaggug     1560

accuucgaca ucgacgccaa cggcaucgug cacgugagcg ccaaggacaa gggcaccggc     1620

agagagcagc agaucgugau ccagagcagc ggcggccuga gcaaggacga caucgagaac     1680

auggugaaga acgccgagaa guacgccgag gaggacagaa gaaagaagga gagaguggag     1740

gccgugaaca uggccgaggg caucauccac gacaccgaga ccaagaugga ggaguucaag     1800

gaccagcugc ccgccgacga gugcaacaag cugaaggagg agaucagcaa gaugagagag     1860

cugcuggcca gaaaggacag cgagaccggc gagaacauca gacaggccgc cagcagccug     1920

cagcaggcca gccugaagcu guucgagaug gccuacaaga agauggccag cgagagagag     1980

ggcagcggca gcagcggcac cggcgagcag aaggaggacc agaaggagga gaagcaguga     2040


<210>  7695
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP70__Homo_sapiens__ABF50973

<400>  7695
augaucagcg ccuccagagc ugccgcggcu cggcuggugg gcgccgccgc uucucgcggg       60

cccaccgccg cuagacacca ggacagcugg aacggacucu cccaugaggc cuuccggcug      120

gucucucgca gagauuacgc gagcgaagcc auuaagggcg cuguuguggg gaucgaccuu      180

ggaacaacga auagcugcgu ggccgucaug gagggcaaac aagcuaaggu gcuggaaaac      240

gccgaggggg cgcggaccac accuucuguu guggccuuua ccgcugaugg agaacgccuc      300

gucggcaugc cggccaaaag acaggcugug acaaauccca acaauaccuu cuaugccaca      360

aagcggcuga uuggccgcag auacgacgau ccugagguuc agaaagacau caagaacgug      420

cccuuuaaga uuguccgggc cagcaauggg gaugcuuggg uggaggcgca cggaaaacuu      480

uauuccccua gccagaucgg cgccuucgug cugaugaaga ugaaagaaac cgcugagaac      540

uaccucgggc auacggccaa gaaugccguc aucaccguuc ccgcuuauuu uaacgacucu      600

caacgccagg ccacaaaaga ugcgggacag auuuccggcc ugaaugugcu gagagugauc      660

aacgaaccua ccgcugccgc ccucgcuuac gggcuggaca agagcgagga uaaggucauu      720

gccguguaug accuuggagg cggcacauuc gauaucucua uucuggagau ccagaaaggg      780

guuuuugaag ugaaguccac caauggagac acguuccucg gcggggagga cuuugaucaa      840

gcucugcuuc ggcacauugu caaagaguuc aagcgcgaaa caggagugga ccugaccaaa      900

gauaacaugg cccuccagag aguucgggaa gcggccgaga aggcuaaaug ugagcugucc      960

ucuuccgugc agacagacau caaucugccg uaccucacca uggauagcuc cggccccaag     1020

caucugaaca ugaaacuuac cagagcccag uuugaaggga ucgucacaga ccugauucgc     1080

cggacgaucg cuccuugcca aaaggccaug caggaugcgg aggugucuaa gagcgacauu     1140

ggagaaguca uccucguggg cggcaugacc agaaugccca aaguucagca aacagugcag     1200

gaucuguucg ggcgcgcccc uuccaaggcu gucaaccccg acgaggccgu ggcuauugga     1260

gccgccaucc agggcggggu ucuugcugga gaugugaccg acguccugcu ccuggacgug     1320

acaccgcuga gccucggcau cgaaacccug ggcggcgugu uuacgaaacu uauuaaucgg     1380

aacacaacca ucccuaccaa gaagucucag guuuucucca cagcggccga uggacaaacc     1440

caggucgaga uuaaagugug ucagggcgag agagaaaugg cuggggacaa uaagcugcuc     1500

ggacaguuca cacugaucgg cauucccccu gcuccccgcg gggugcccca aaucgagguc     1560

acguuugaua ucgacgccaa cggaauugug cacguuagcg ccaaagauaa gggcaccggg     1620

cgggaacagc agaucgugau ucagucuagc ggcggacuuu ccaaagacga uaucgagaau     1680

auggucaaga acgccgaaaa guacgcggag gaggacagac gcaaaaagga acggguggag     1740

gcuguuaaua uggccgaagg cauuauccac gauacagaga ccaaaaugga ggaguucaag     1800

gaccaacugc cugccgauga augcaacaaa cucaaggaag agauuucuaa gaugagagaa     1860

cugcuggcuc gcaaagacag cgagacaggg gagaauaucc ggcaggccgc guccagccuc     1920

cagcaggcuu cucugaaacu uuuugaaaug gccuauaaga agauggccuc cgagagagaa     1980

ggaagcgggu cuuccgggac cggagagcaa aaagaagauc agaaggagga gaaacaguga     2040


<210>  7696
<211>  2040
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP70__Homo_sapiens__ABF50973

<400>  7696
augauauccg caagcagagc agcagcagca agauuaguag gugcugcagc aucaagagga       60

ccaacagcgg caaggcauca agacaguugg aacggauuau cacaugaggc auucagauua      120

guaagcagaa gagauuaugc aagcgaagcu auaaaaggag caguaguagg gauagaucua      180

ggaacaacaa auagcugugu agcggugaug gaaggaaaac aagcaaaagu auuagaaaac      240

gcugaaggag caagaacaac uccaagugua guagcauuca cagcagaugg cgaaagauua      300

guaggaaugc cggcaaaaag acaagcagug acaaauccaa auaacacauu uuaugcaaca      360

aaaagacuaa uugggaggag guaugaugau ccagaaguac aaaaagauau aaaaaaugug      420

ccguuuaaaa uaguaagagc caguaacgga gacgcuuggg uugaagcuca cggaaaauua      480

uauucuccau cacaaauagg ggcauuugua cucaugaaaa ugaaagaaac ugcggaaaac      540

uaucugggcc auacggcaaa aaaugcaguu auaacaguac cagcuuacuu caaugauagc      600

caaagacaag caacaaaaga ugcaggucaa auaagugguu uaaauguacu ucguguaaua      660

aaugaaccca cagcggcagc acuagcauac ggauuagaua aaucagaaga caaaguaaua      720

gccguuuacg aucugggagg gggaacauuu gauauaagca uccuagaaau ucaaaaaggg      780

guauucgaag uaaaaaguac aaauggagac acguuccucg gaggugaaga uuucgaucaa      840

gcacuucuaa ggcauauagu aaaagaauuu aaaagagaaa ccgguguuga ccuaacaaaa      900

gacaauaugg cguugcaaag aguaagagag gcugcagaaa aagcaaaaug cgaacuauca      960

agcaguguac aaacagauau aaaucugccg uauuuaacaa uggauucauc aggaccgaaa     1020

cauuuaaaua ugaaacuuac aagagcccaa uuugaaggaa uagucacgga cuuaauaaga     1080

aggacgauag caccauguca aaaagcaaug caagaugcag aaguaaguaa aagcgacaua     1140

ggagaaguca uuuugguagg ggguaugacu agaaugccaa aaguccaaca aacaguccaa     1200

gauuuauucg gaagagcgcc aagcaaagcu guaaauccag augaagcagu agcgauagga     1260

gcagcaauac aaggaggagu auuggcugga gauguuacug acguauuauu auuggacgug     1320

acaccauuaa guuuaggaau agaaacauua ggagggguau uuacaaaauu aauaaauaga     1380

aauacaacca uucccacaaa aaaaucacaa guauucagua cagcagcuga uggucaaaca     1440

caaguugaaa uaaaaguaug ucaaggcgaa agagaaaugg caggugauaa uaaauuauua     1500

ggacaauuca cacuaauagg uauaccaccu gcuccuagag gaguuccuca aauugaaguu     1560

acuuuugaca uagacgcaaa cggaauagua cauguaagug caaaagacaa aggaacagga     1620

agagaacaac agauaguaau acaaaguagc ggaggauuau caaaagacga uauagaaaau     1680

auggucaaaa augcugaaaa auaugcagag gaagaucgac ggaaaaaaga aaggguagaa     1740

gcggugaaua uggcugaagg aauaauacau gauacggaga caaaaaugga ggaauuuaaa     1800

gaucaauuac cggcugacga augcaauaaa uuaaaagaag aaauaagcaa aaugcgagaa     1860

uugcuggcac gaaaagauag cgaaacaggc gaaaauauua gacaagcagc aaguagcuua     1920

caacaagcau cuuuaaaacu auuugaaaug gcguauaaaa agauggcaag ugaaagagaa     1980

ggaaguggaa gcucaggaac gggagaacaa aaagaagauc aaaaagaaga aaaacaauaa     2040


<210>  7697
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP90__Homo_sapiens__P07900

<400>  7697

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             


Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 


Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 


Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     


Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         


Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             


Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 


Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 


Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     


Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         


Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             


Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 


Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 


Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     


Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         


Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             


Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 


Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 


Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         


Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 


Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 


Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     


Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         


Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             


Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 


Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 


Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         


<210>  7698
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP90__Homo_sapiens__AAA63194

<400>  7698
augccugagg aaacccagac ccaagaccaa ccgauggagg aggaggaggu ugagacguuc       60

gccuuucagg cagaaauugc ccaguugaug ucauugauca ucaauacuuu cuacucgaac      120

aaagagaucu uucugagaga gcucauuuca aauucaucag augcauugga caaaauccgg      180

uaugaaagcu ugacagaucc caguaaauua gacucuggga aagagcugca uauuaaccuu      240

auaccgaaca aacaagaucg aacucucacu auuguggaua cuggaauugg aaugaccaag      300

gcugacuuga ucaauaaccu ugguacuauc gccaagucug ggaccaaagc guucauggaa      360

gcuuugcagg cuggugcaga uaucucuaug auuggccagu ucgguguugg uuuuuauucu      420

gcuuauuugg uugcugagaa aguaacugug aucaccaaac auaacgauga ugagcaguac      480

gcuugggagu ccucagcagg gggaucauuc acagugagga cagacacagg ugaaccuaug      540

ggucguggaa caaaaguuau ccuacaccug aaagaagacc aaacugagua cuuggaggaa      600

cgaagaauaa aggagauugu gaagaaacau ucucaguuua uuggauaucc cauuacucuu      660

uuuguggaga aggaacguga uaaagaagua agcgaugaug aggcugaaga aaaggaagac      720

aaagaagaag aaaaagaaaa agaagagaaa gagucggaag acaaaccuga aauugaagau      780

guugguucug augaggaaga agaaaagaag gauggugaca agaagaagaa gaagaagauu      840

aaggaaaagu acaucgauca agaagagcuc aacaaaacaa agcccaucug gaccagaaau      900

cccgacgaua uuacuaauga ggaguacgga gaauucuaua agagcuugac caaugacugg      960

gaagaucacu uggcagugaa gcauuuuuca guugaaggac aguuggaauu cagagcccuu     1020

cuauuugucc cacgacgugc uccuuuugau cuguuugaaa acagaaagaa aaagaacaac     1080

aucaaauugu auguacgcag aguuuucauc auggauaacu gugaggagcu aaucccugaa     1140

uaucugaacu ucauuagagg ggugguagac ucggaggauc ucccucuaaa cauaucccgu     1200

gagauguugc aacaaagcaa aauuuugaaa guuaucagga agaauuuggu caaaaaaugc     1260

uuagaacucu uuacugaacu ggcggaagau aaagagaacu acaagaaauu cuaugagcag     1320

uucucuaaaa acauaaagcu uggaauacac gaagacucuc aaaaucggaa gaagcuuuca     1380

gagcuguuaa gguacuacac aucugccucu ggugaugaga ugguuucucu caaggacuac     1440

ugcaccagaa ugaaggagaa ccagaaacau aucuauuaua ucacagguga gaccaaggac     1500

cagguagcua acucagccuu uguggaacgu cuucggaaac auggcuuaga agugaucuau     1560

augauugagc ccauugauga guacuguguc caacagcuga aggaauuuga ggggaagacu     1620

uuagugucag ucaccaaaga aggccuggaa cuuccagagg augaagaaga gaaaaagaag     1680

caggaagaga aaaaaacaaa guuugagaac cucugcaaaa ucaugaaaga cauauuggag     1740

aaaaaaguug aaaagguggu ugugucaaac cgauugguga caucuccaug cuguauuguc     1800

acaagcacau auggcuggac agcaaacaug gagagaauca ugaaagcuca agcccuaaga     1860

gacaacucaa caauggguua cauggcagca aagaaacacc uggagauaaa cccugaccau     1920

uccauuauug agaccuuaag gcaaaaggca gaggcugaua agaacgacaa gucugugaag     1980

gaucugguca ucuugcuuua ugaaacugcg cuccugucuu cuggcuucag ucuggaagau     2040

ccccagacac augcuaacag gaucuacagg augaucaaac uuggucuggg uauugaugaa     2100

gaugacccua cugcugauga uaccagugcu gcuguaacug aagaaaugcc accccuugaa     2160

ggagaugacg acacaucacg cauggaagaa guagacuaa                            2199


<210>  7699
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP90__Homo_sapiens__AAA63194

<400>  7699
augcccgagg agacccagac ccaggaccag cccauggagg aggaggaggu ggagacguuc       60

gccuuccagg ccgagaucgc gcagcugaug agccucauca ucaacaccuu cuacuccaac      120

aaggagaucu uccugcgcga gcugaucagc aacuccagcg acgcccucga caagauccgg      180

uacgaguccc ugaccgaccc cagcaagcug gacuccggca aggagcucca caucaaccug      240

auccccaaca agcaggaccg cacccugacg aucgucgaca ccgggaucgg caugaccaag      300

gccgaccuca ucaacaaccu ggggaccauc gccaagagcg gcacgaaggc cuucauggag      360

gcgcugcagg ccggggccga caucuccaug aucggccagu ucggcguggg guucuacagc      420

gccuaccucg uggcggagaa ggucaccgug aucaccaagc acaacgacga cgagcaguac      480

gccugggagu ccagcgccgg cggguccuuc accgugcgga cggacaccgg cgagcccaug      540

gggcgcggca ccaaggucau ccugcaccug aaggaggacc agaccgagua ccucgaggag      600

cggcgcauca aggagaucgu gaagaagcac agccaguuca ucggcuaccc gaucacgcug      660

uucguggaga aggagcggga caaggagguc uccgacgacg aggccgagga gaaggaggac      720

aaggaggagg agaaggagaa ggaggagaag gagagcgagg acaagcccga gaucgaggac      780

gugggguccg acgaggagga ggagaagaag gacggcgaca agaagaagaa gaagaagauc      840

aaggagaagu acaucgacca ggaggagcug aacaagacca agcccaucug gacccgcaac      900

cccgacgaca ucaccaacga ggaguacggg gaguucuaca agagccucac gaacgacugg      960

gaggaccacc uggccgugaa gcacuucucc gucgagggcc agcuggaguu ccgggcgcuc     1020

cuguucgugc cgcgccgggc ccccuucgac cuguucgaga accgcaagaa gaagaacaac     1080

aucaagcucu acgugcggcg cgucuucauc auggacaacu gcgaggagcu gauccccgag     1140

uaccugaacu ucauccgggg cgugguggac agcgaggacc ucccccugaa caucagccgc     1200

gagaugcugc agcaguccaa gauccucaag gucauccgga agaaccuggu gaagaagugc     1260

cuggagcugu ucaccgagcu cgccgaggac aaggagaacu acaagaaguu cuacgagcag     1320

uucagcaaga acaucaagcu ggggauccac gaggacuccc agaaccgcaa gaagcucagc     1380

gagcugcugc gguacuacac cuccgccagc ggcgacgaga uggugucccu caaggacuac     1440

ugcacccgca ugaaggagaa ccagaagcac aucuacuaca ucacggggga gaccaaggac     1500

caggucgcca acagcgcguu cguggagcgg cugcgcaagc acggccugga ggugaucuac     1560

augaucgagc cgaucgacga guacugcguc cagcagcuca aggaguucga ggggaagacc     1620

cugguguccg ucaccaagga gggccuggag cuccccgagg acgaggagga gaagaagaag     1680

caggaggaga agaagacgaa guucgagaac cugugcaaga ucaugaagga cauccuggag     1740

aagaaggugg agaagguggu cgugagcaac cgccucguga ccucccccug cugcaucguc     1800

accagcaccu acggcuggac ggccaacaug gagcggauca ugaaggccca ggcccugcgc     1860

gacaacucca ccauggggua cauggccgcg aagaagcacc uggagaucaa ccccgaccac     1920

agcaucaucg agacccugcg gcagaaggcc gaggccgaca agaacgacaa guccgugaag     1980

gaccucguga uccugcugua cgagaccgcc cuccugagcu ccggcuucag ccuggaggac     2040

ccgcagacgc acgccaaccg caucuaccgg augaucaagc ucgggcuggg caucgacgag     2100

gacgacccca ccgcggacga caccuccgcc gccgucaccg aggagaugcc gccccuggag     2160

ggggacgacg acaccagccg cauggaggag guggacuga                            2199


<210>  7700
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP90__Homo_sapiens__AAA63194

<400>  7700
augcccgagg agacccagac ccaggaccag cccauggagg aggaggaggu cgagaccuuc       60

gccuuccagg ccgagaucgc ccagcucaug ucccucauca ucaacaccuu cuacuccaac      120

aaggagaucu uccuccgcga gcucaucucc aacuccuccg acgcccucga caagauccgc      180

uacgaguccc ucaccgaccc cuccaagcuc gacuccggca aggagcucca caucaaccuc      240

auccccaaca agcaggaccg cacccucacc aucgucgaca ccggcaucgg caugaccaag      300

gccgaccuca ucaacaaccu cggcaccauc gccaaguccg gcaccaaggc cuucauggag      360

gcccuccagg ccggcgccga caucuccaug aucggccagu ucggcgucgg cuucuacucc      420

gccuaccucg ucgccgagaa ggucaccguc aucaccaagc acaacgacga cgagcaguac      480

gccugggagu ccuccgccgg cggcuccuuc accguccgca ccgacaccgg cgagcccaug      540

ggccgcggca ccaaggucau ccuccaccuc aaggaggacc agaccgagua ccucgaggag      600

cgccgcauca aggagaucgu caagaagcac ucccaguuca ucggcuaccc caucacccuc      660

uucgucgaga aggagcgcga caaggagguc uccgacgacg aggccgagga gaaggaggac      720

aaggaggagg agaaggagaa ggaggagaag gaguccgagg acaagcccga gaucgaggac      780

gucggcuccg acgaggagga ggagaagaag gacggcgaca agaagaagaa gaagaagauc      840

aaggagaagu acaucgacca ggaggagcuc aacaagacca agcccaucug gacccgcaac      900

cccgacgaca ucaccaacga ggaguacggc gaguucuaca agucccucac caacgacugg      960

gaggaccacc ucgccgucaa gcacuucucc gucgagggcc agcucgaguu ccgcgcccuc     1020

cucuucgucc cccgccgcgc ccccuucgac cucuucgaga accgcaagaa gaagaacaac     1080

aucaagcucu acguccgccg cgucuucauc auggacaacu gcgaggagcu cauccccgag     1140

uaccucaacu ucauccgcgg cgucgucgac uccgaggacc ucccccucaa caucucccgc     1200

gagaugcucc agcaguccaa gauccucaag gucauccgca agaaccucgu caagaagugc     1260

cucgagcucu ucaccgagcu cgccgaggac aaggagaacu acaagaaguu cuacgagcag     1320

uucuccaaga acaucaagcu cggcauccac gaggacuccc agaaccgcaa gaagcucucc     1380

gagcuccucc gcuacuacac cuccgccucc ggcgacgaga uggucucccu caaggacuac     1440

ugcacccgca ugaaggagaa ccagaagcac aucuacuaca ucaccggcga gaccaaggac     1500

caggucgcca acuccgccuu cgucgagcgc cuccgcaagc acggccucga ggucaucuac     1560

augaucgagc ccaucgacga guacugcguc cagcagcuca aggaguucga gggcaagacc     1620

cucgucuccg ucaccaagga gggccucgag cuccccgagg acgaggagga gaagaagaag     1680

caggaggaga agaagaccaa guucgagaac cucugcaaga ucaugaagga cauccucgag     1740

aagaaggucg agaaggucgu cgucuccaac cgccucguca ccucccccug cugcaucguc     1800

accuccaccu acggcuggac cgccaacaug gagcgcauca ugaaggccca ggcccuccgc     1860

gacaacucca ccaugggcua cauggccgcc aagaagcacc ucgagaucaa ccccgaccac     1920

uccaucaucg agacccuccg ccagaaggcc gaggccgaca agaacgacaa guccgucaag     1980

gaccucguca uccuccucua cgagaccgcc cuccucuccu ccggcuucuc ccucgaggac     2040

ccccagaccc acgccaaccg caucuaccgc augaucaagc ucggccucgg caucgacgag     2100

gacgacccca ccgccgacga caccuccgcc gccgucaccg aggagaugcc cccccucgag     2160

ggcgacgacg acaccucccg cauggaggag gucgacuga                            2199


<210>  7701
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP90__Homo_sapiens__AAA63194

<400>  7701
augcccgagg aaacccagac acaagaccag ccuauggagg aagaggaagu ggagacuuuc       60

gccuuucagg cugagaucgc acagcugaug agccucauua uaaacacguu cuacuccaau      120

aaggaaaucu uucuuagaga gcugauuucu aacucaagug augccuugga caaaaucagg      180

uaugagagcu uaaccgaucc auccaagcug gacucuggca aagagcuaca cauuaaucuc      240

aucccgaaca agcaagaucg gacacugacu auagucgaca ccgggaucgg aaugacaaaa      300

gcggaucuua uuaauaaccu ggguaccauc gcuaagucgg gcacuaaggc cuucauggag      360

gcauugcagg ccggggcuga cauuucaaug aucggacagu uuggcguugg uuucuacagc      420

gcauaucucg uggccgaaaa aguaacagug auaaccaagc auaaugauga cgagcaguac      480

gcuugggaaa guuccgccgg gggaucuuuu acgguccgca cugauaccgg cgagcccaug      540

ggccgaggga caaaagugau ucugcaccug aaggaagacc aaacugagua ucucgaggaa      600

cguagaauca aagagauugu uaagaagcau agccaguuca ucggauaccc uaucaccuua      660

uuuguggaaa aagagaggga uaaggaaguc uccgacgacg aggcggagga aaaagaggau      720

aaggaagagg aaaaagagaa ggaggaaaaa gagucagaag acaagccaga gauugaggau      780

guggguagug acgaagagga agagaagaaa gauggcgaca agaaaaagaa aaagaagaua      840

aaagaaaagu auaucgauca ggaggagcug aacaaaacaa agcccauuug gacccggaau      900

ccugacgaua ucacgaacga agaguacggg gaguucuaca aaagccuuac uaaugacugg      960

gaagaucacu uggcaguaaa gcauuuuucu guugaaggac agcuggaguu ccgcgcccua     1020

cucuuugugc caagaagggc ucccuucgac cuguucgaga accggaagaa aaagaauaac     1080

auaaaacuuu auguccgccg aguguuuauu auggacaauu gcgaagaacu gaucccugaa     1140

uacuugaacu ucaucagagg cguggucgau uccgaggacc ucccacugaa cauuucaagg     1200

gaaauguuac aacagagcaa gauccugaaa guuauucgga agaaucucgu gaagaaaugu     1260

cuugagcugu uuacagaguu ggccgaagau aaggagaacu auaaaaaguu cuacgaacag     1320

uuuaguaaaa auauaaagcu agguauccac gaggacucuc aaaaccguaa aaagcugucc     1380

gagcuccugc gcuauuacac cagcgcaucg ggggaugaaa ugguaucucu uaaggacuau     1440

ugcacuagaa ugaaagagaa ucagaagcac auuuacuaca ucacaggaga aaccaaagau     1500

cagguggcua acuccgccuu cgucgagagg cugcggaagc auggcuugga agugaucuau     1560

augauugagc cgauagacga guacuguguu cagcaacuca aagaauuuga gggcaagacg     1620

cuggugucag ucaccaagga aggguuagag cugcccgaag augaggagga gaaaaagaaa     1680

caggaagaaa agaaaacaaa guucgagaau cuaugcaaga ucaugaaaga cauucucgaa     1740

aagaaagugg agaagguagu ugugaguaac cgacugguca cuagcccuug uugcaucgug     1800

accuccacau auggauggac ugcgaauaug gagcgcauua ugaaagccca ggcacuuaga     1860

gauaacucua ccauggguua cauggcugcc aagaagcacu uggaaaucaa uccagaccau     1920

agcauaaucg agacacugag gcagaaagcu gaagccgaua agaacgacaa aucagucaag     1980

gaccucguga uucugcuuua ugagaccgca cuguugaguu ccggcuuuag ccucgaggau     2040

ccccaaacuc acgccaaucg gaucuaccgc augauuaaac ugggguuagg aaucgacgaa     2100

gaugacccua cggcugauga cacaucugcg gcaguuaccg aggaaaugcc accccuggag     2160

ggcgaugacg auacuucaag aauggaagag guggacuga                            2199


<210>  7702
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP90__Homo_sapiens__AAA63194

<400>  7702
augcccgagg agacccagac ccaggaccag cccauggagg aggaggaggu ggagaccuuc       60

gccuuccagg ccgagaucgc ccagcugaug agccugauca ucaacaccuu cuacagcaac      120

aaggagaucu uccugagaga gcugaucagc aacagcagcg acgcccugga caagaucaga      180

uacgagagcc ugaccgaccc cagcaagcug gacagcggca aggagcugca caucaaccug      240

auccccaaca agcaggacag aacccugacc aucguggaca ccggcaucgg caugaccaag      300

gccgaccuga ucaacaaccu gggcaccauc gccaagagcg gcaccaaggc cuucauggag      360

gcccugcagg ccggcgccga caucagcaug aucggccagu ucggcguggg cuucuacagc      420

gccuaccugg uggccgagaa ggugaccgug aucaccaagc acaacgacga cgagcaguac      480

gccugggaga gcagcgccgg cggcagcuuc accgugagaa ccgacaccgg cgagcccaug      540

ggcagaggca ccaaggugau ccugcaccug aaggaggacc agaccgagua ccuggaggag      600

agaagaauca aggagaucgu gaagaagcac agccaguuca ucggcuaccc caucacccug      660

uucguggaga aggagagaga caaggaggug agcgacgacg aggccgagga gaaggaggac      720

aaggaggagg agaaggagaa ggaggagaag gagagcgagg acaagcccga gaucgaggac      780

gugggcagcg acgaggagga ggagaagaag gacggcgaca agaagaagaa gaagaagauc      840

aaggagaagu acaucgacca ggaggagcug aacaagacca agcccaucug gaccagaaac      900

cccgacgaca ucaccaacga ggaguacggc gaguucuaca agagccugac caacgacugg      960

gaggaccacc uggccgugaa gcacuucagc guggagggcc agcuggaguu cagagcccug     1020

cuguucgugc ccagaagagc ccccuucgac cuguucgaga acagaaagaa gaagaacaac     1080

aucaagcugu acgugagaag aguguucauc auggacaacu gcgaggagcu gauccccgag     1140

uaccugaacu ucaucagagg cgugguggac agcgaggacc ugccccugaa caucagcaga     1200

gagaugcugc agcagagcaa gauccugaag gugaucagaa agaaccuggu gaagaagugc     1260

cuggagcugu ucaccgagcu ggccgaggac aaggagaacu acaagaaguu cuacgagcag     1320

uucagcaaga acaucaagcu gggcauccac gaggacagcc agaacagaaa gaagcugagc     1380

gagcugcuga gauacuacac cagcgccagc ggcgacgaga uggugagccu gaaggacuac     1440

ugcaccagaa ugaaggagaa ccagaagcac aucuacuaca ucaccggcga gaccaaggac     1500

cagguggcca acagcgccuu cguggagaga cugagaaagc acggccugga ggugaucuac     1560

augaucgagc ccaucgacga guacugcgug cagcagcuga aggaguucga gggcaagacc     1620

cuggugagcg ugaccaagga gggccuggag cugcccgagg acgaggagga gaagaagaag     1680

caggaggaga agaagaccaa guucgagaac cugugcaaga ucaugaagga cauccuggag     1740

aagaaggugg agaagguggu ggugagcaac agacugguga ccagccccug cugcaucgug     1800

accagcaccu acggcuggac cgccaacaug gagagaauca ugaaggccca ggcccugaga     1860

gacaacagca ccaugggcua cauggccgcc aagaagcacc uggagaucaa ccccgaccac     1920

agcaucaucg agacccugag acagaaggcc gaggccgaca agaacgacaa gagcgugaag     1980

gaccugguga uccugcugua cgagaccgcc cugcugagca gcggcuucag ccuggaggac     2040

ccccagaccc acgccaacag aaucuacaga augaucaagc ugggccuggg caucgacgag     2100

gacgacccca ccgccgacga caccagcgcc gccgugaccg aggagaugcc cccccuggag     2160

ggcgacgacg acaccagcag aauggaggag guggacuga                            2199


<210>  7703
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP90__Homo_sapiens__AAA63194

<400>  7703
augcccgagg aaacccagac acaagaccag cccauggagg aagaggaagu ggagacguuc       60

gccuuucagg cugagaucgc ccagcugaug agccucauua ucaacaccuu cuacuccaau      120

aaggaaauuu uucugagaga gcuuaucucu aacagcuccg augcgcugga caaaauucgg      180

uaugaaucuc ucacagaucc gagcaagcug gacuccggca aagagcuuca caucaaucug      240

auccccaaca agcaagaucg cacccucaca auugucgaca ccgggaucgg aaugacaaaa      300

gcugaucuga uuaauaaccu gggcaccauc gccaagucug ggacgaaggc cuucauggag      360

gcucuccagg ccggagcuga cauuagcaug aucggccagu uugggguugg auucuacucc      420

gccuaucugg uggcggaaaa agugaccguc auuacaaagc auaaugauga cgagcaguac      480

gccugggaaa gcucugcugg cggcuccuuu accgugagaa cagauaccgg ggagccuaug      540

ggacggggca cgaaaguuau ccuucaccug aaggaagacc aaacagagua ucucgaggaa      600

cgcagaauca aagagauugu gaagaagcau agccaguuca ucggguaccc cauuacccug      660

uuugucgaaa aagagcggga uaaggaagug ucugacgacg aggccgagga aaaagaggau      720

aaggaagagg aaaaagagaa ggaggaaaaa gaguccgaag acaagccuga gaucgaggau      780

guuggaagcg acgaagagga agagaagaaa gauggcgaca agaaaaagaa aaagaagauu      840

aaagaaaagu auaucgauca ggaggagcuu aacaaaacaa agcccaucug gacccgcaau      900

ccugacgaua uuaccaacga agaguacggg gaguucuaca aaucucugac aaaugacugg      960

gaggaucacc ucgcugugaa gcauuuuucc gucgaaggac agcuggaguu cagagcccug     1020

cucuuugugc cgcggcgcgc gcccuucgac cuguucgaga acagaaagaa aaagaauaac     1080

aucaaacuuu augugcggcg cgucuuuauu auggacaauu gcgaagaacu gaucccugaa     1140

uaccucaacu ucauuagagg cguuguggau agcgaggacc ugccccuuaa caucucccgg     1200

gaaaugcugc aacagucuaa gauccucaaa gugauucgca agaaucuggu caagaaaugu     1260

cuggagcucu uuacggagcu ggccgaagau aaggagaacu auaaaaaguu cuacgaacag     1320

uuuagcaaaa auaucaaacu uggcauucac gaggacuccc aaaacagaaa gaagcugagc     1380

gagcuccugc gguauuacac cucugcuucc ggggaugaaa uggugagccu uaaggacuau     1440

ugcacaagaa ugaaagagaa ucagaagcac aucuacuaca uuaccggaga aacaaaagau     1500

cagguugcca acucugcuuu cguggagcgc cugcggaagc auggccucga agucaucuau     1560

augauugagc cuaucgacga guacugugug cagcaacuga aagaauuuga ggggaagacc     1620

cugguuagcg ugacgaagga aggacucgag cugcccgaag augaggagga gaaaaagaaa     1680

caggaagaaa agaaaacaaa guucgagaau cuuugcaaga ucaugaaaga cauucuggaa     1740

aagaaagucg agaagguggu cguguccaac agacucguua ccucuccgug uugcaucgug     1800

accagcacau auggcuggac cgccaauaug gagcgcauua ugaaagccca ggcucugcgg     1860

gauaacucca caauggggua cauggcggcc aagaagcacc uggaaaucaa uccugaccau     1920

agcauuaucg agacgcuuag acagaaagcu gaagccgaua agaacgacaa aucugucaag     1980

gaccucguga uccugcugua ugagaccgcc cuccugucca gcggauuuuc ucuugaggau     2040

ccccaaacac acgcuaaucg cauuuaccgg augaucaaac ugggccucgg cauugacgaa     2100

gaugacccua ccgccgauga cacauccgcg gcuguuaccg aggaaaugcc uccccuggag     2160

ggggaugacg auacgagcag aauggaagag guggacuga                            2199


<210>  7704
<211>  2199
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP90__Homo_sapiens__AAA63194

<400>  7704
augccagaag aaacacaaac acaagaucaa ccaauggaag aagaggaagu ggaaacauuu       60

gcauuccaag cagaaaucgc acaacucaug ucauuaauaa uaaauaccuu cuacaguaac      120

aaagaaauuu ucuuacgaga auuaauaagc aauaguagcg acgcacuaga caaaauuaga      180

uacgaaaguu uaacagaccc uagcaaacua gacucaggaa aagaauuaca cauaaaucuc      240

auaccuaaua aacaagacag aacacuaacg auaguagaca ccggaauagg aaugacaaaa      300

gcagaucuaa uaaauaacuu aggaacaauc gcaaaaucag gcacaaaagc auucauggaa      360

gcauuacaag cgggagcaga uauaucaaug aucggacaau ucggugucgg auuuuacucc      420

gcauaucuag ucgcagaaaa aguaacggua auaacaaagc acaaugauga ugaacaauau      480

gcaugggaaa guucagccgg aggaagcuuc acgguaagaa cagauacagg cgaaccaaug      540

ggaagaggaa caaaaguaau acuacaccua aaagaagacc aaacggaaua uuuagaagaa      600

agaagaauca aagaaauagu aaaaaaacac ucacaauuua uaggauaccc aauuacacua      660

uucguagaaa aagaaagaga caaagaaguc ucugacgaug aagcggaaga gaaagaagac      720

aaagaagaag aaaaagaaaa ggaagaaaaa gaaagugaag acaaaccaga gauagaagac      780

guaggaagug acgaagaaga agaaaaaaaa gacggugaca aaaagaaaaa aaaaaagaua      840

aaagaaaaau auauagauca agaagaacua aacaaaacaa aaccaauaug gacacgaaac      900

ccagaugaua uaacuaauga agaauacgga gaauucuaca aaagcuuaac aaaugacugg      960

gaagaucacu uagcaguuaa acauuuuuca guagaaggac aauuagaauu cagagcacua     1020

cuauucguac cuagacgugc gccauucgau cucuucgaaa aucguaaaaa aaaaaauaac     1080

auaaaacuau acguaagaag gguauucauc auggacaauu gcgaagaauu aaucccagaa     1140

uaccuaaacu uuauaagagg aguaguagau ucggaagauu uaccauuaaa uauaagcaga     1200

gaaaugcuac aacagaguaa aauacugaaa gugauacgaa aaaaccuggu aaaaaaaugc     1260

cucgaauuau ucacagaauu agcagaagac aaagaaaacu auaaaaaauu uuaugaacaa     1320

uucaguaaaa acauaaaauu agguauacac gaagauaguc aaaacagaaa aaaacuaagc     1380

gaacuacuaa gguacuacac auccgcaucc ggggaugaaa ugguaagcuu gaaagauuac     1440

uguacaagaa ugaaagaaaa ccaaaaacac auauacuaca uaacagggga aacaaaagau     1500

caagucgcga auucagcguu uguagaaaga cuaagaaaac auggacuaga aguaauauau     1560

augauagaac caauagauga auacugcgua caacaauuaa aagaauuuga aggaaaaaca     1620

cuaguaagug uaaccaaaga aggcuuagaa uugcccgaag acgaagaaga aaaaaagaaa     1680

caggaagaaa aaaaaacaaa auuugaaaau cuaugcaaga uaaugaaaga uauauuggaa     1740

aaaaaaguag aaaaaguagu gguaagcaau agauuaguaa caucaccaug cugcauagua     1800

acgagcacau acggauggac ggcaaauaug gaaagaauua ugaaagcaca agccuuaagg     1860

gauaacucaa caaugggaua cauggcagca aaaaaacacc uagaaauaaa uccagaccau     1920

agcauaauag aaacauuaag acaaaaagcc gaagcagaua aaaaugauaa gagcguaaaa     1980

gaucuaguaa uauuacuaua cgaaacagca cuauugucaa gcggcuuuag uuuagaagau     2040

ccacagaccc augcaaaucg aaucuaccgc augauuaaau uaggauuagg aaucgacgaa     2100

gacgauccua cagcugacga cacaucugca gccguuacag aagaaaugcc accacuagaa     2160

ggagaugacg acaccaguag aauggaggaa guagacuaa                            2199


<210>  7705
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP90__Homo_sapiens__P08238

<400>  7705

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  7706
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP90__Homo_sapiens__AAA36026

<400>  7706
augccugagg aagugcacca uggagaggag gagguggaga cuuuugccuu ucaggcagaa       60

auugcccaac ucaugucccu caucaucaau accuucuauu ccaacaagga gauuuuccuu      120

cgggaguuga ucucuaaugc uucugaugcc uuggacaaga uucgcuauga gagccugaca      180

gacccuucga aguuggacag ugguaaagag cugaaaauug acaucauccc caacccucag      240

gaacguaccc ugacuuuggu agacacaggc auuggcauga ccaaagcuga ucucauaaau      300

aauuugggaa ccauugccaa gucugguacu aaagcauuca uggaggcucu ucaggcuggu      360

gcagacaucu ccaugauugg gcaguuuggu guuggcuuuu auucugccua cuugguggca      420

gagaaagugg uugugaucac aaagcacaac gaugaugaac aguaugcuug ggagucuucu      480

gcuggagguu ccuucacugu gcgugcugac cauggugagc ccauuggcag ggguaccaaa      540

gugauccucc aucuuaaaga agaucagaca gaguaccuag aagagaggcg ggucaaagaa      600

guagugaaga agcauucuca guucauaggc uaucccauca cccuuuauuu ggagaaggaa      660

cgagagaagg aaauuaguga ugaugaggca gaggaagaga aaggugagaa agaagaggaa      720

gauaaagaug augaagaaaa acccaagauc gaagaugugg guucagauga ggaggaugac      780

agcgguaagg auaagaagaa gaaaacuaag aagaucaaag agaaauacau ugaucaggaa      840

gaacuaaaca agaccaagcc uauuuggacc agaaacccug augacaucac ccaagaggag      900

uauggagaau ucuacaagag ccucacuaau gacugggaag accacuuggc agucaagcac      960

uuuucuguag aaggucaguu ggaauucagg gcauugcuau uuauuccucg ucgggcuccc     1020

uuugaccuuu uugagaacaa gaagaaaaag aacaacauca aacucuaugu ccgccgugug     1080

uucaucaugg acagcuguga ugaguugaua ccagaguauc ucaauuuuau ccguggugug     1140

guugacucug aggaucugcc ccugaacauc ucccgagaaa ugcuccagca gagcaaaauc     1200

uugaaaguca uucgcaaaaa cauuguuaag aagugccuug agcucuucuc ugagcuggca     1260

gaagacaagg agaauuacaa gaaauucuau gaggcauucu cuaaaaaucu caagcuugga     1320

auccacgaag acuccacuaa ccgccgccgc cugucugagc ugcugcgcua ucauaccucc     1380

cagucuggag augagaugac aucucuguca gaguauguuu cucgcaugaa ggagacacag     1440

aaguccaucu auuacaucac uggugagagc aaagagcagg uggccaacuc agcuuuugug     1500

gagcgagugc ggaaacgggg cuucgaggug guauauauga ccgagcccau ugacgaguac     1560

ugugugcagc agcucaagga auuugauggg aagagccugg ucucaguuac caaggagggu     1620

cuggagcugc cugaggauga ggaggagaag aagaagaugg aagagagcaa ggcaaaguuu     1680

gagaaccucu gcaagcucau gaaagaaauc uuagauaaga agguugagaa ggugacaauc     1740

uccaauagac uugugucuuc accuugcugc auugugacca gcaccuacgg cuggacagcc     1800

aauauggagc ggaucaugaa agcccaggca cuucgggaca acuccaccau gggcuauaug     1860

auggccaaaa agcaccugga gaucaacccu gaccacccca uuguggagac gcugcggcag     1920

aaggcugagg ccgacaagaa ugauaaggca guuaaggacc ugguggugcu gcuguuugaa     1980

accgcccugc uaucuucugg cuuuucccuu gaggaucccc agacccacuc caaccgcauc     2040

uaucgcauga ucaagcuagg ucuagguauu gaugaagaug aaguggcagc agaggaaccc     2100

aaugcugcag uuccugauga gauccccccu cucgagggcg augaggaugc gucucgcaug     2160

gaagaagucg auuag                                                      2175


<210>  7707
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP90__Homo_sapiens__AAA36026

<400>  7707
augcccgagg aggugcacca cggcgaggag gaggucgaga ccuucgccuu ccaggccgag       60

aucgcgcagc ugaugagccu caucaucaac accuucuacu ccaacaagga gaucuuccug      120

cgcgagcuga ucagcaacgc cuccgacgcc cucgacaaga uccgguacga gagccugacg      180

gacccgucca agcuggacag cgggaaggag cucaagaucg acaucauccc caacccccag      240

gagcgcaccc ugacccuggu ggacaccggc aucgggauga cgaaggccga ccucaucaac      300

aaccugggca ccaucgccaa guccgggacc aaggcguuca uggaggcccu gcaggccggc      360

gccgacauca gcaugaucgg ccaguucggg gugggcuucu acuccgcgua ccucgucgcc      420

gagaaggugg uggucaucac caagcacaac gacgacgagc aguacgccug ggagagcucc      480

gccgggggca gcuucacggu gcgggccgac cacggggagc ccaucggccg cggcaccaag      540

gugauccugc accugaagga ggaccagacc gaguaccucg aggagcggcg cgucaaggag      600

guggugaaga agcacuccca guucaucggg uacccgauca cccuguaccu ggagaaggag      660

cgggagaagg agaucagcga cgacgaggcg gaggaggaga agggcgagaa ggaggaggag      720

gacaaggacg acgaggagaa gcccaagauc gaggacgucg gguccgacga ggaggacgac      780

agcggcaagg acaagaagaa gaagacgaag aagaucaagg agaaguacau cgaccaggag      840

gagcucaaca agaccaagcc caucuggacc cgcaaccccg acgacaucac ccaggaggag      900

uacggcgagu ucuacaaguc ccugacgaac gacugggagg accaccuggc cgugaagcac      960

uucagcgugg aggggcagcu cgaguuccgg gcccugcugu ucaucccgcg ccgggccccc     1020

uucgaccucu ucgagaacaa gaagaagaag aacaacauca agcuguacgu ccgccgggug     1080

uucaucaugg acuccugcga cgagcugauc cccgaguacc ucaacuucau ccgcggcgug     1140

gucgacagcg aggaccugcc ccugaacauc agccgggaga ugcuccagca guccaagauc     1200

cugaagguga uccgcaagaa caucgugaag aagugccugg agcuguucag cgagcucgcc     1260

gaggacaagg agaacuacaa gaaguucuac gaggcguucu ccaagaaccu gaagcucggg     1320

auccacgagg acagcaccaa ccggcgccgg cuguccgagc ugcuccgcua ccacaccagc     1380

caguccggcg acgagaugac cagccugucc gaguacguca gccggaugaa ggagacgcag     1440

aaguccaucu acuacaucac cggggagagc aaggagcagg ucgccaacuc cgccuucgug     1500

gagcgcgugc gcaagcgggg cuucgaggug gucuacauga ccgagccgau cgacgaguac     1560

ugcgugcagc agcugaagga guucgacggc aagagccucg uguccgucac caaggagggg     1620

cuggagcugc ccgaggacga ggaggagaag aagaagaugg aggagagcaa ggccaaguuc     1680

gagaaccucu gcaagcugau gaaggagauc cuggacaaga agguggagaa ggugacgauc     1740

uccaaccgcc ucgucagcuc ccccugcugc aucgugacca gcaccuacgg cuggaccgcc     1800

aacauggagc ggaucaugaa ggcgcaggcc cugcgcgaca acagcacgau gggguacaug     1860

auggccaaga agcaccugga gaucaacccc gaccacccga ucguggagac ccugcggcag     1920

aaggccgagg ccgacaagaa cgacaaggcg gucaaggacc ucguggugcu gcuguucgag     1980

accgcccucc uguccagcgg cuucucccug gaggaccccc agacccacag caaccgcauc     2040

uaccggauga ucaagcucgg gcugggcauc gacgaggacg aggucgccgc cgaggagccc     2100

aacgcggccg ugcccgacga gaucccgccc cuggagggcg acgaggacgc cucccgcaug     2160

gaggaggugg acuga                                                      2175


<210>  7708
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP90__Homo_sapiens__AAA36026

<400>  7708
augcccgagg agguccacca cggcgaggag gaggucgaga ccuucgccuu ccaggccgag       60

aucgcccagc ucaugucccu caucaucaac accuucuacu ccaacaagga gaucuuccuc      120

cgcgagcuca ucuccaacgc cuccgacgcc cucgacaaga uccgcuacga gucccucacc      180

gaccccucca agcucgacuc cggcaaggag cucaagaucg acaucauccc caacccccag      240

gagcgcaccc ucacccucgu cgacaccggc aucggcauga ccaaggccga ccucaucaac      300

aaccucggca ccaucgccaa guccggcacc aaggccuuca uggaggcccu ccaggccggc      360

gccgacaucu ccaugaucgg ccaguucggc gucggcuucu acuccgccua ccucgucgcc      420

gagaaggucg ucgucaucac caagcacaac gacgacgagc aguacgccug ggaguccucc      480

gccggcggcu ccuucaccgu ccgcgccgac cacggcgagc ccaucggccg cggcaccaag      540

gucauccucc accucaagga ggaccagacc gaguaccucg aggagcgccg cgucaaggag      600

gucgucaaga agcacuccca guucaucggc uaccccauca cccucuaccu cgagaaggag      660

cgcgagaagg agaucuccga cgacgaggcc gaggaggaga agggcgagaa ggaggaggag      720

gacaaggacg acgaggagaa gcccaagauc gaggacgucg gcuccgacga ggaggacgac      780

uccggcaagg acaagaagaa gaagaccaag aagaucaagg agaaguacau cgaccaggag      840

gagcucaaca agaccaagcc caucuggacc cgcaaccccg acgacaucac ccaggaggag      900

uacggcgagu ucuacaaguc ccucaccaac gacugggagg accaccucgc cgucaagcac      960

uucuccgucg agggccagcu cgaguuccgc gcccuccucu ucaucccccg ccgcgccccc     1020

uucgaccucu ucgagaacaa gaagaagaag aacaacauca agcucuacgu ccgccgcguc     1080

uucaucaugg acuccugcga cgagcucauc cccgaguacc ucaacuucau ccgcggcguc     1140

gucgacuccg aggaccuccc ccucaacauc ucccgcgaga ugcuccagca guccaagauc     1200

cucaagguca uccgcaagaa caucgucaag aagugccucg agcucuucuc cgagcucgcc     1260

gaggacaagg agaacuacaa gaaguucuac gaggccuucu ccaagaaccu caagcucggc     1320

auccacgagg acuccaccaa ccgccgccgc cucuccgagc uccuccgcua ccacaccucc     1380

caguccggcg acgagaugac cucccucucc gaguacgucu cccgcaugaa ggagacccag     1440

aaguccaucu acuacaucac cggcgagucc aaggagcagg ucgccaacuc cgccuucguc     1500

gagcgcgucc gcaagcgcgg cuucgagguc gucuacauga ccgagcccau cgacgaguac     1560

ugcguccagc agcucaagga guucgacggc aagucccucg ucuccgucac caaggagggc     1620

cucgagcucc ccgaggacga ggaggagaag aagaagaugg aggaguccaa ggccaaguuc     1680

gagaaccucu gcaagcucau gaaggagauc cucgacaaga aggucgagaa ggucaccauc     1740

uccaaccgcc ucgucuccuc ccccugcugc aucgucaccu ccaccuacgg cuggaccgcc     1800

aacauggagc gcaucaugaa ggcccaggcc cuccgcgaca acuccaccau gggcuacaug     1860

auggccaaga agcaccucga gaucaacccc gaccacccca ucgucgagac ccuccgccag     1920

aaggccgagg ccgacaagaa cgacaaggcc gucaaggacc ucgucguccu ccucuucgag     1980

accgcccucc ucuccuccgg cuucucccuc gaggaccccc agacccacuc caaccgcauc     2040

uaccgcauga ucaagcucgg ccucggcauc gacgaggacg aggucgccgc cgaggagccc     2100

aacgccgccg uccccgacga gauccccccc cucgagggcg acgaggacgc cucccgcaug     2160

gaggaggucg acuga                                                      2175


<210>  7709
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP90__Homo_sapiens__AAA36026

<400>  7709
augcccgagg aagugcacca uggcgaggaa gaggucgaaa ccuucgccuu ucaggcugag       60

aucgcacaac ugaugagccu cauuauaaac acauucuacu ccaauaagga gaucuuucuu      120

agagaacuga uuucuaacgc cucagacgcg uuggauaaaa ucagguauga gaguuuaacu      180

gacccuagca agcuggauuc cgggaaagaa cuaaagauug acaucauacc aaauccgcag      240

gagcggacgc ucacccuggu ugauacagga aucgguauga cuaaagcuga ccuuauuaac      300

aaucugggca ccaucgccaa gucugggaca aaggcauuca uggaggccuu gcaggcugga      360

gcagauauuu cgaugaucgg ccaguuuggu gugggguucu acucagccua ucucguagcu      420

gaaaaagugg ucgugauaac caagcacaac gacgaugagc aauacgccug ggaaagcagu      480

gcgggaggcu ccuuuacugu ucgcgcagac cauggcgagc ccauugggcg aggaacaaaa      540

gugauccugc accugaagga agaucagacc gaguaucucg aggaacguag agucaaagag      600

gugguaaaga agcauucuca guucauuggu uacccuauca cguuauaucu ggaaaaagag      660

agggaaaagg agaucagcga cgaugaggcc gaagaggaaa aaggcgagaa ggaagaggag      720

gacaaagacg augaagagaa gccaaaaauu gaagacguug gguccgauga ggaggacgau      780

ucaggaaagg acaagaaaaa gaaaacuaag aaaauaaagg aaaaguacau cgaucaggag      840

gaacuuaaua aaaccaagcc cauuuggaca cggaacccug acgauaucac ucaagaggaa      900

uacggcgagu uuuauaaaag uuugaccaau gacugggagg aucaccuggc ugugaagcac      960

uucagcgucg aaggucagcu agaguuucgc gcccuccugu ucauaccaag aagggcaccc     1020

uuugaccuuu ucgaaaacaa aaagaagaaa aauaacauua agcuguacgu gcggcgcgug     1080

uucaucaugg acucuugcga ugaguugauc ccugaauauc ucaauuuuau ucgagggguc     1140

guugacuccg aggaucugcc auuaaacauc ucaagagaga ugcugcagca gagcaaaauu     1200

cucaagguga uaaggaaaaa uaucguaaag aagugucuug aacuguucag ugaguuggcu     1260

gaagacaaag agaacuacaa gaaauuuuau gaagccuucu cuaagaaccu aaaacugggc     1320

auucaugagg auuccacaaa ucggcgucgc cucagcgagc ugcuuagaua ccacaccucg     1380

caaucuggag acgaaaugac gucccuguca gaguauguga guaggaugaa ggaaacucag     1440

aaaagcaucu acuacaucac aggcgagucc aaggagcagg ucgcgaacuc ugccuuugug     1500

gaacggguuc gaaagcgcgg guucgaggug gucuauauga ccgaaccgau ugaugaguac     1560

ugcgugcaac aguugaaaga auuugacgga aagagccucg uaucaguuac uaaagagggu     1620

cuggaguuac ccgaagauga ggaagagaag aaaaagaugg aagagaguaa ggcaaaauuc     1680

gagaaucugu guaagcuaau gaaagaaaua cucgacaaga aaguggagaa ggucacaauc     1740

uccaacagac uggugagcuc uccuugcugu auugucaccu caacguaugg cuggaccgcu     1800

aauauggaaa ggaucaugaa ggcccaggcc cuucgggaua acaguacaau gggguacaug     1860

auggcuaaaa agcauuugga gauuaaucca gaccacccca ucguggaaac ucugcgccag     1920

aaagcagagg ccgauaagaa cgacaaagcu guuaaggacc ucgugguacu gcuuuuugag     1980

accgcgcugu ugagcuccgg auucucucuc gaagauccuc aaacacacuc gaauagaaua     2040

uauaggauga ucaagcuggg cuuagguauu gacgaggaug aagucgcagc cgaggagcca     2100

aacgcugccg ugcccgacga aaucccgccu cuggaggggg augaagacgc aagccguaug     2160

gaggaaguug auuga                                                      2175


<210>  7710
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP90__Homo_sapiens__AAA36026

<400>  7710
augcccgagg aggugcacca cggcgaggag gagguggaga ccuucgccuu ccaggccgag       60

aucgcccagc ugaugagccu gaucaucaac accuucuaca gcaacaagga gaucuuccug      120

agagagcuga ucagcaacgc cagcgacgcc cuggacaaga ucagauacga gagccugacc      180

gaccccagca agcuggacag cggcaaggag cugaagaucg acaucauccc caacccccag      240

gagagaaccc ugacccuggu ggacaccggc aucggcauga ccaaggccga ccugaucaac      300

aaccugggca ccaucgccaa gagcggcacc aaggccuuca uggaggcccu gcaggccggc      360

gccgacauca gcaugaucgg ccaguucggc gugggcuucu acagcgccua ccugguggcc      420

gagaaggugg uggugaucac caagcacaac gacgacgagc aguacgccug ggagagcagc      480

gccggcggca gcuucaccgu gagagccgac cacggcgagc ccaucggcag aggcaccaag      540

gugauccugc accugaagga ggaccagacc gaguaccugg aggagagaag agugaaggag      600

guggugaaga agcacagcca guucaucggc uaccccauca cccuguaccu ggagaaggag      660

agagagaagg agaucagcga cgacgaggcc gaggaggaga agggcgagaa ggaggaggag      720

gacaaggacg acgaggagaa gcccaagauc gaggacgugg gcagcgacga ggaggacgac      780

agcggcaagg acaagaagaa gaagaccaag aagaucaagg agaaguacau cgaccaggag      840

gagcugaaca agaccaagcc caucuggacc agaaaccccg acgacaucac ccaggaggag      900

uacggcgagu ucuacaagag ccugaccaac gacugggagg accaccuggc cgugaagcac      960

uucagcgugg agggccagcu ggaguucaga gcccugcugu ucauccccag aagagccccc     1020

uucgaccugu ucgagaacaa gaagaagaag aacaacauca agcuguacgu gagaagagug     1080

uucaucaugg acagcugcga cgagcugauc cccgaguacc ugaacuucau cagaggcgug     1140

guggacagcg aggaccugcc ccugaacauc agcagagaga ugcugcagca gagcaagauc     1200

cugaagguga ucagaaagaa caucgugaag aagugccugg agcuguucag cgagcuggcc     1260

gaggacaagg agaacuacaa gaaguucuac gaggccuuca gcaagaaccu gaagcugggc     1320

auccacgagg acagcaccaa cagaagaaga cugagcgagc ugcugagaua ccacaccagc     1380

cagagcggcg acgagaugac cagccugagc gaguacguga gcagaaugaa ggagacccag     1440

aagagcaucu acuacaucac cggcgagagc aaggagcagg uggccaacag cgccuucgug     1500

gagagaguga gaaagagagg cuucgaggug guguacauga ccgagcccau cgacgaguac     1560

ugcgugcagc agcugaagga guucgacggc aagagccugg ugagcgugac caaggagggc     1620

cuggagcugc ccgaggacga ggaggagaag aagaagaugg aggagagcaa ggccaaguuc     1680

gagaaccugu gcaagcugau gaaggagauc cuggacaaga agguggagaa ggugaccauc     1740

agcaacagac uggugagcag ccccugcugc aucgugacca gcaccuacgg cuggaccgcc     1800

aacauggaga gaaucaugaa ggcccaggcc cugagagaca acagcaccau gggcuacaug     1860

auggccaaga agcaccugga gaucaacccc gaccacccca ucguggagac ccugagacag     1920

aaggccgagg ccgacaagaa cgacaaggcc gugaaggacc ugguggugcu gcuguucgag     1980

accgcccugc ugagcagcgg cuucagccug gaggaccccc agacccacag caacagaauc     2040

uacagaauga ucaagcuggg ccugggcauc gacgaggacg agguggccgc cgaggagccc     2100

aacgccgccg ugcccgacga gauccccccc cuggagggcg acgaggacgc cagcagaaug     2160

gaggaggugg acuga                                                      2175


<210>  7711
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP90__Homo_sapiens__AAA36026

<400>  7711
augcccgagg aagugcacca uggcgaggaa gaggucgaaa ccuucgccuu ucaggcugag       60

aucgcccaac ugaugagccu cauuaucaac acauucuacu ccaauaagga gauuuuucug      120

agagaacuua ucucuaacgc gagcgacgcu cuggauaaaa uucgguauga gucccucacg      180

gacccuucua agcuggauag cgggaaagaa cuuaagaucg acaucauucc gaauccccag      240

gagcgcaccc ugacacucgu ugauaccgga aucggcauga caaaagccga ccugauuaac      300

aaucugggga ccaucgccaa guccggaaca aaggcuuuca uggaggcccu ccaggcuggc      360

gccgauauuu cuaugaucgg gcaguuugga gugggcuucu acagcgcgua ucugguggcc      420

gaaaaagucg ugguuauuac caagcacaac gacgaugagc aauacgcuug ggaauccagc      480

gccggcgggu cuuuuacggu gagagcugac cauggagagc cuaucggccg ggggaccaaa      540

gucauccuuc accugaagga agaucagaca gaguaucucg aggaacgcag agugaaagag      600

guugugaaga agcauuccca guucauugga uaccccauca cccuguaucu ugaaaaagag      660

cgggaaaagg agauuagcga cgaugaggcc gaagaggaaa aaggcgagaa ggaagaggag      720

gacaaagacg augaagagaa gccuaaaauc gaagacgucg ggucugauga ggaggacgau      780

uccggaaagg acaagaaaaa gaaaacaaag aaaauuaagg aaaaguacau cgaucaggag      840

gaacugaaua aaaccaagcc caucuggacg cgcaacccug acgauauuac acaagaggaa      900

uacggcgagu uuuauaaaag ccucaccaau gacugggagg aucaccuggc ggugaagcac      960

uucucugugg aaggccagcu ggaguuuaga gcccuccugu ucaucccgcg gcgcgcuccc     1020

uuugaccuuu ucgaaaacaa aaagaagaaa aauaacauua agcuguacgu cagacggguu     1080

uucaucaugg acuccugcga ugagcucauu ccugaauauc ugaauuuuau ccgcggggug     1140

guggacagcg aggaucuucc ccugaacauc uccagagaga ugcuccagca gucuaaaauu     1200

cugaagguca uccggaaaaa uauugugaag aagugucugg aacucuucag cgagcuggcc     1260

gaagacaaag agaacuacaa gaaauuuuau gaggcuuucu ccaagaaccu uaaacuggga     1320

auccaugagg auagcacaaa ucgcagacgg cucucugagc ugcuuagaua ccacaccucc     1380

caaagcggcg acgaaaugac cucucugagc gaguauguuu cccgcaugaa ggaaacacag     1440

aaaucuauuu acuacaucac gggggagagc aaggaacagg uggccaacuc cgccuuuguc     1500

gaacggguga gaaagcgcgg auucgagguu guguauauga ccgaaccuau ugaugaguac     1560

ugcguccaac agcucaaaga auuugacggc aagagccugg ugucugucac aaaagagggg     1620

cuggagcucc ccgaagauga ggaagagaag aaaaagaugg aagaguccaa ggcuaaauuc     1680

gagaaucugu guaaacuuau gaaggaaauc cuggacaaga aaguggagaa gguuaccauc     1740

agcaaccggc ucgugucuuc cccgugcugu auugucacaa gcaccuaugg auggacggcg     1800

aauauggaaa gaaucaugaa ggcccaggcu cugcgcgaua acuccacaau gggcuacaug     1860

auggccaaaa agcaucugga gauuaauccu gaccacccca ucguggaaac ccuucggcag     1920

aaagccgagg cugauaagaa cgacaaagcc guuaaggacc ucgugguccu gcuguuugag     1980

accgcgcucc ugucuagcgg cuucucccuu gaagauccuc aaacacacuc uaauagaauu     2040

uaucgcauga ucaagcuggg gcucggaauc gacgaggaug aaguggcugc cgaggagccc     2100

aacgccgcug ugcccgacga aauuccuccg cuggagggcg augaagacgc cagccggaug     2160

gaggaaguug auuga                                                      2175


<210>  7712
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       HSP90__Homo_sapiens__AAA36026

<400>  7712
augccugaag aaguacacca uggagaagaa gaaguagaaa cuuuugcauu ccaagcagaa       60

aucgcucaac uaaugagcuu aauaauaaau acguuuuaua guaauaaaga aauauuccua      120

agagaauuaa uaucaaaugc aagugaugca uuagacaaaa uaagauacga gaguuugacc      180

gacccaucaa aauuagacag uggaaaagaa cuaaaaaucg acauaauacc aaauccacaa      240

gaaagaacac uaacacuagu agacacagga auaggcauga caaaagcuga uuuaaucaac      300

aauuuaggaa caauagccaa aucagggacu aaagccuuca uggaggcacu acaagcaggu      360

gcagauauau caaugauagg acaauuugga gugggauuuu acucagcaua cuuaguagcc      420

gaaaaaguag uaguaauuac aaaacauaau gacgacgagc aauaugcaug ggaguccagc      480

gcaggaggaa guuucacagu aagagcggac cauggagagc caauagggag agguacaaaa      540

guaauauugc acuuaaaaga agaccaaaca gaauacuuag aagaaagaag aguaaaagaa      600

guagugaaaa aacacagcca auucaucgga uacccuauaa ccuuauaccu agaaaaagag      660

agagaaaaag aaauuaguga ugacgaagcu gaagaagaaa aaggggaaaa agaagaagaa      720

gacaaagacg augaagaaaa accuaaaaua gaggauguag ggagcgacga agaagacgac      780

agcggaaagg acaaaaaaaa aaaaacaaaa aaaauaaaag aaaaauauau agaccaagaa      840

gaacuaaaca aaacaaaacc aauauggacu agaaacccag acgauauaac ccaggaagaa      900

uauggagaau ucuacaaauc guuaacaaau gacugggaag aucaucuugc gguaaaacac      960

uucaguguag aaggacaguu agaauuccga gcacuacugu ucauuccaag aagagcaccc     1020

uuugaccuau uugaaaauaa aaagaaaaaa aacaacauaa aauuauacgu aagacgaguu     1080

uucauaaugg auucauguga cgaauuaaua ccagaauacc uaaacuuuau acgaggagug     1140

guugacucag aagauuuacc acuaaacauc ucaagagaga ugcuacaaca aaguaaaaua     1200

cugaaaguaa uaagaaaaaa cauugugaaa aaauguuuag aauuauucag cgaauuagcu     1260

gaagauaaag aaaauuauaa gaaauuuuac gaagcauuca gcaaaaaucu gaaacuagga     1320

auacacgaag auucaaccaa uagaagacga cugagcgaac uacuucggua ccauacaagc     1380

cagaguggag augaaaugac gucauuauca gaauaugucu caagaaugaa agaaacgcaa     1440

aaaucuauau acuacauaac uggagaaagc aaagaacaag ucgcaaacuc agcauucguu     1500

gaaagaguac guaagagagg auucgagguu guauacauga cugagccaau agaugaauac     1560

ugcguacaac aauuaaagga auucgaugga aaaucauuag uuagcguaac gaaagaagga     1620

cuagaauugc cagaagacga agaagaaaaa aaaaaaaugg aagaaagcaa agccaaauuu     1680

gaaaauuuau gcaaauugau gaaagaaaua cuagauaaaa aaguggaaaa agugacaaua     1740

ucaaauagac uuguaagcuc gccgugcugu auuguaacau ccacauacgg guggacggca     1800

aacauggaga gaauaaugaa agcccaagca cugcgagaca acucaaccau gggauacaug     1860

auggccaaaa agcacuugga aauaaacccc gaucauccaa uaguagaaac auuaagacaa     1920

aaagcagaag cagacaaaaa cgauaaagcu gucaaagauc uuguaguacu acuguuugaa     1980

acagcacuau uaaguagcgg auuuaguuua gaagauccac agacacacag caacagaauc     2040

uacagaauga uuaaauuagg ucuaggaaua gacgaggaug aaguagcggc agaagaacca     2100

aaugcggcag uaccugacga aauaccacca cuggagggag augaagacgc aucaagaaug     2160

gaagaagugg auuaa                                                      2175


<210>  7713
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__P07237

<400>  7713

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  7714
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__AAC13652

<400>  7714
augcugcgcc gcgcucugcu gugccuggcc guggccgccc uggugcgcgc cgacgccccc       60

gaggaggagg accacguccu ggugcugcgg aaaagcaacu ucgcggaggc gcuggcggcc      120

cacaaguacc ugcuggugga guucuaugcc ccuuggugug gccacugcaa ggcucuggcc      180

ccugaguaug ccaaagccgc ugggaagcug aaggcagaag guuccgagau cagguuggcc      240

aagguggacg ccacggagga gucugaccug gcccagcagu acggcgugcg cggcuauccc      300

accaucaagu ucuucaggaa uggagacacg gcuuccccca aggaauauac agcuggcaga      360

gaggcugaug acaucgugaa cuggcugaag aagcgcacgg gcccggcugc caccacccug      420

ccugacggcg cagcugcaga guccuuggug gaguccagcg agguggcugu caucggcuuc      480

uucaaggacg uggagucgga cucugccaag caguuuuugc aggcagcaga ggccaucgau      540

gacauaccau uugggaucac uuccaacagu gacguguucu ccaaauacca gcucgacaaa      600

gaugggguug uccucuuuaa gaaguuugau gaaggccgga acaacuuuga aggggagguc      660

accaaggaga accugcugga cuuuaucaaa cacaaccagc ugccccuugu caucgaguuc      720

accgagcaga cagccccgaa gauuuuugga ggugaaauca agacucacau ccugcuguuc      780

uugcccaaga gugugucuga cuaugacggc aaacugagca acuucaaaac agcagccgag      840

agcuucaagg gcaagauccu guucaucuuc aucgacagcg accacaccga caaccagcgc      900

auccucgagu ucuuuggccu gaagaaggaa gagugcccgg ccgugcgccu caucacccug      960

gaggaggaga ugaccaagua caagcccgaa ucggaggagc ugacggcaga gaggaucaca     1020

gaguucugcc accgcuuccu ggagggcaaa aucaagcccc accugaugag ccaggagcug     1080

ccggaggacu gggacaagca gccugucaag gugcuuguug ggaagaacuu ugaagacgug     1140

gcuuuugaug agaaaaaaaa cgucuuugug gaguucuaug ccccauggug uggucacugc     1200

aaacaguugg cucccauuug ggauaaacug ggagagacgu acaaggacca ugagaacauc     1260

gucaucgcca agauggacuc gacugccaac gagguggagg ccgucaaagu gcacagcuuc     1320

cccacacuca aguucuuucc ugccagugcc gacaggacgg ucauugauua caacggggaa     1380

cgcacgcugg augguuuuaa gaaauuccug gagagcggug gccaggaugg ggcaggggau     1440

gaugacgauc ucgaggaccu ggaagaagca gaggagccag acauggagga agacgaugau     1500

cagaaagcug ugaaagauga acuguaa                                         1527


<210>  7715
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7715
augcugcgcc gggcccuccu gugccuggcc guggcggccc ucguccgcgc cgacgccccc       60

gaggaggagg accacgugcu ggugcugcgc aagagcaacu ucgccgaggc gcucgccgcc      120

cacaaguacc ugcuggucga guucuacgcc ccguggugcg gccacugcaa ggcgcucgcc      180

cccgaguacg ccaaggccgc cgggaagcug aaggcggagg gcuccgagau ccggcuggcc      240

aagguggacg ccaccgagga gagcgaccuc gcccagcagu acggggugcg gggcuacccc      300

accaucaagu ucuuccgcaa cggggacacg gccuccccca aggaguacac cgcgggccgg      360

gaggccgacg acaucgucaa cuggcugaag aagcgcaccg gcccggccgc caccacgcug      420

cccgacgggg ccgcggccga gagccucgug gaguccagcg agguggccgu caucggcuuc      480

uucaaggacg uggaguccga cagcgccaag caguuccugc aggccgcgga ggccaucgac      540

gacauccccu ucgggaucac cuccaacagc gacguguucu ccaaguacca gcuggacaag      600

gacggcgucg ugcuguucaa gaaguucgac gaggggcgga acaacuucga gggcgaggug      660

accaaggaga accugcugga cuucaucaag cacaaccagc ucccccuggu caucgaguuc      720

accgagcaga cggccccgaa gaucuucggc ggggagauca agacccacau ccuccucuuc      780

cugcccaaga gcguguccga cuacgacggc aagcugagca acuucaagac cgccgcggag      840

uccuucaagg ggaagauccu cuucaucuuc aucgacagcg accacaccga caaccagcgc      900

auccuggagu ucuucggccu gaagaaggag gagugccccg ccgugcggcu caucacgcug      960

gaggaggaga ugaccaagua caagcccgag uccgaggagc ugaccgccga gcgcaucacc     1020

gaguucugcc accgguuccu cgagggcaag aucaagccgc accugaugag ccaggagcug     1080

cccgaggacu gggacaagca gcccgucaag gugcucgugg ggaagaacuu cgaggacguc     1140

gccuucgacg agaagaagaa cguguucgug gaguucuacg cccccuggug cggccacugc     1200

aagcagcugg cgccgaucug ggacaagcug ggggagacgu acaaggacca cgagaacauc     1260

gucaucgcca agauggacuc caccgccaac gagguggagg ccgucaaggu gcacagcuuc     1320

cccacccuca aguucuuccc cgccagcgcg gaccgcaccg ugaucgacua caacggcgag     1380

cggacgcugg acggguucaa gaaguuccug gaguccggcg gccaggacgg ggccggcgac     1440

gacgacgacc ucgaggaccu ggaggaggcc gaggagcccg acauggagga ggacgacgac     1500

cagaaggccg ucaaggacga gcuguga                                         1527


<210>  7716
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7716
augcuccgcc gcgcccuccu cugccucgcc gucgccgccc ucguccgcgc cgacgccccc       60

gaggaggagg accacguccu cguccuccgc aaguccaacu ucgccgaggc ccucgccgcc      120

cacaaguacc uccucgucga guucuacgcc cccuggugcg gccacugcaa ggcccucgcc      180

cccgaguacg ccaaggccgc cggcaagcuc aaggccgagg gcuccgagau ccgccucgcc      240

aaggucgacg ccaccgagga guccgaccuc gcccagcagu acggcguccg cggcuacccc      300

accaucaagu ucuuccgcaa cggcgacacc gccuccccca aggaguacac cgccggccgc      360

gaggccgacg acaucgucaa cuggcucaag aagcgcaccg gccccgccgc caccacccuc      420

cccgacggcg ccgccgccga gucccucguc gaguccuccg aggucgccgu caucggcuuc      480

uucaaggacg ucgaguccga cuccgccaag caguuccucc aggccgccga ggccaucgac      540

gacauccccu ucggcaucac cuccaacucc gacgucuucu ccaaguacca gcucgacaag      600

gacggcgucg uccucuucaa gaaguucgac gagggccgca acaacuucga gggcgagguc      660

accaaggaga accuccucga cuucaucaag cacaaccagc ucccccucgu caucgaguuc      720

accgagcaga ccgcccccaa gaucuucggc ggcgagauca agacccacau ccuccucuuc      780

cuccccaagu ccgucuccga cuacgacggc aagcucucca acuucaagac cgccgccgag      840

uccuucaagg gcaagauccu cuucaucuuc aucgacuccg accacaccga caaccagcgc      900

auccucgagu ucuucggccu caagaaggag gagugccccg ccguccgccu caucacccuc      960

gaggaggaga ugaccaagua caagcccgag uccgaggagc ucaccgccga gcgcaucacc     1020

gaguucugcc accgcuuccu cgagggcaag aucaagcccc accucauguc ccaggagcuc     1080

cccgaggacu gggacaagca gcccgucaag guccucgucg gcaagaacuu cgaggacguc     1140

gccuucgacg agaagaagaa cgucuucguc gaguucuacg cccccuggug cggccacugc     1200

aagcagcucg cccccaucug ggacaagcuc ggcgagaccu acaaggacca cgagaacauc     1260

gucaucgcca agauggacuc caccgccaac gaggucgagg ccgucaaggu ccacuccuuc     1320

cccacccuca aguucuuccc cgccuccgcc gaccgcaccg ucaucgacua caacggcgag     1380

cgcacccucg acggcuucaa gaaguuccuc gaguccggcg gccaggacgg cgccggcgac     1440

gacgacgacc ucgaggaccu cgaggaggcc gaggagcccg acauggagga ggacgacgac     1500

cagaaggccg ucaaggacga gcucuga                                         1527


<210>  7717
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7717
augcugagaa gggcccuccu uugccuggcu guggcagccu ugguccgggc ggacgcuccc       60

gaggaagagg aucacguuuu agugcugcgc aagagcaacu ucgccgaagc acuagccgcu      120

cauaaauacc uccugguaga guuuuaugca ccuuggugug gccacugcaa ggcccuugcu      180

ccagaauacg ccaaagcggc agggaagcug aaagccgagg gauccgagau ccgauuggcu      240

aagguggacg ccaccgaaga gucugaucuc gcacagcaau augguguccg uggcuacccg      300

acaauuaagu ucuuuagaaa uggggacacu gcuucaccca aagaauauac ggccggaagg      360

gaggcggaug acauagugaa cuggcugaag aaacggaccg gcccugccgc aacaacucug      420

ccagauggug cugccgcuga gagucucguu gaaagcuccg agguggccgu caucggguuc      480

uuuaaggacg uggaaucuga uucggcaaaa caguucuuac aggccgcuga ggcgauugac      540

gauauccccu uuggaauuac cucaaauagc gacguauuca guaaguacca gcuggauaag      600

gacggcguug ugcuuuuuaa aaaguucgac gaaggccgca acaauuuuga gggggagguc      660

acaaaagaaa acuugcugga uuucaucaag cauaaucaac uaccucucgu gauagaguuu      720

accgaacaga cugcaccaaa aaucuucgga ggugagauua agacacacau ccugcuuuuc      780

cugcccaaau ccgugucuga cuaugauggc aaguugagca acuuuaagac cgccgcugaa      840

uccuucaaag ggaagauucu cuuuaucuuc auagacucag aucauacgga caaucagaga      900

auuuuagagu uuuucggacu gaaaaaggag gaauguccug ccgucaggcu gaucacucuc      960

gaggaagaga ugaccaaaua caagccagaa agugaggagc uuacagcaga acggauuacu     1020

gaguuuugcc accgcuuccu ggaaggcaag aucaaaccgc acuugaugag ccaggagcua     1080

cccgaggauu gggacaagca accuguuaaa gugcugguag guaagaacuu ugaagaugug     1140

gccuucgacg agaaaaagaa ugucuuugug gaguucuacg cuccauggug ugggcauugc     1200

aagcagcucg cccccaucug ggauaaacug ggagaaaccu auaaggacca cgaaaacauu     1260

guuauagcaa aaauggacuc uacagcgaau gagguggagg cugucaaggu gcauuccuuu     1320

ccuacccuua aauucuuccc agccucagca gaucgaacgg uaaucgacua caacggcgaa     1380

agaacucugg auggcuuuaa gaaguucuug gagagcgggg gacaggacgg ugccggcgau     1440

gacgaugacc ucgaagaucu ggaggaagcu gaggagcccg acauggaaga ggaugacgau     1500

cagaaagccg uuaaggacga auuauga                                         1527


<210>  7718
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7718
augcugagaa gagcccugcu gugccuggcc guggccgccc uggugagagc cgacgccccc       60

gaggaggagg accacgugcu ggugcugaga aagagcaacu ucgccgaggc ccuggccgcc      120

cacaaguacc ugcuggugga guucuacgcc cccuggugcg gccacugcaa ggcccuggcc      180

cccgaguacg ccaaggccgc cggcaagcug aaggccgagg gcagcgagau cagacuggcc      240

aagguggacg ccaccgagga gagcgaccug gcccagcagu acggcgugag aggcuacccc      300

accaucaagu ucuucagaaa cggcgacacc gccagcccca aggaguacac cgccggcaga      360

gaggccgacg acaucgugaa cuggcugaag aagagaaccg gccccgccgc caccacccug      420

cccgacggcg ccgccgccga gagccuggug gagagcagcg agguggccgu gaucggcuuc      480

uucaaggacg uggagagcga cagcgccaag caguuccugc aggccgccga ggccaucgac      540

gacauccccu ucggcaucac cagcaacagc gacguguuca gcaaguacca gcuggacaag      600

gacggcgugg ugcuguucaa gaaguucgac gagggcagaa acaacuucga gggcgaggug      660

accaaggaga accugcugga cuucaucaag cacaaccagc ugccccuggu gaucgaguuc      720

accgagcaga ccgcccccaa gaucuucggc ggcgagauca agacccacau ccugcuguuc      780

cugcccaaga gcgugagcga cuacgacggc aagcugagca acuucaagac cgccgccgag      840

agcuucaagg gcaagauccu guucaucuuc aucgacagcg accacaccga caaccagaga      900

auccuggagu ucuucggccu gaagaaggag gagugccccg ccgugagacu gaucacccug      960

gaggaggaga ugaccaagua caagcccgag agcgaggagc ugaccgccga gagaaucacc     1020

gaguucugcc acagauuccu ggagggcaag aucaagcccc accugaugag ccaggagcug     1080

cccgaggacu gggacaagca gcccgugaag gugcuggugg gcaagaacuu cgaggacgug     1140

gccuucgacg agaagaagaa cguguucgug gaguucuacg cccccuggug cggccacugc     1200

aagcagcugg cccccaucug ggacaagcug ggcgagaccu acaaggacca cgagaacauc     1260

gugaucgcca agauggacag caccgccaac gagguggagg ccgugaaggu gcacagcuuc     1320

cccacccuga aguucuuccc cgccagcgcc gacagaaccg ugaucgacua caacggcgag     1380

agaacccugg acggcuucaa gaaguuccug gagagcggcg gccaggacgg cgccggcgac     1440

gacgacgacc uggaggaccu ggaggaggcc gaggagcccg acauggagga ggacgacgac     1500

cagaaggccg ugaaggacga gcuguga                                         1527


<210>  7719
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7719
augcugagac gggcccuccu gugccuugcu guggccgcgc ugguccgcgc ugacgccccc       60

gaggaagagg aucacguucu cgugcugaga aagagcaacu ucgccgaagc ucuugccgcu      120

cauaaauacc ugcucgugga guuuuaugcc ccuuggugug gccacugcaa ggcgcuggcc      180

ccggaauacg cuaaagccgc ugggaagcug aaagccgagg gauccgagau ccggcucgcg      240

aaggucgacg ccaccgaaga gucugaucug gcucagcaau auggcgugcg cggguacccc      300

acaauuaagu ucuuuagaaa uggagacacg gccagcccua aagaauauac cgcuggccgg      360

gaggccgaug acaucguuaa cuggcuuaag aaacgcacag ggcccgccgc uaccacacug      420

ccugauggag cggccgcuga gucccucgug gaaucuagcg aggucgccgu gauuggcuuc      480

uuuaaggacg uugaauccga uucugccaaa caguuccugc aggcugccga ggcgaucgac      540

gauauucccu uuggcaucac cagcaauucc gacguguuca gcaaguacca gcuugauaag      600

gacggggucg ugcuguuuaa aaaguucgac gaaggaagaa acaauuuuga gggcgaggug      660

acaaaagaaa accuccugga uuucaucaag cauaaucaac ugccucucgu cauugaguuu      720

accgaacaga cggcuccgaa aaucuucggg ggagagauua agacccacau ccugcuuuuc      780

cugcccaaau cuguuuccga cuaugauggc aagcucagca acuuuaagac agccgccgaa      840

ucuuucaaag ggaagauucu guuuaucuuc auugacuccg aucauaccga caaucagcgg      900

auccuugagu uuuucggacu gaaaaaggag gaauguccug cugugcgccu caucacacug      960

gaggaagaga ugaccaaaua caagcccgaa agcgaggagc ugacggccga aagaauuaca     1020

gaguuuugcc accgguuccu cgaaggcaag aucaaaccuc accugauguc ucaggagcuu     1080

cccgaggauu gggacaagca accggugaaa guccuggugg gcaagaacuu ugaagauguu     1140

gcuuucgacg agaaaaagaa uguguuuguc gaguucuacg ccccuuggug ugggcauugc     1200

aagcagcucg cgcccauuug ggauaaacug ggagaaaccu auaaggacca cgaaaacauc     1260

gugauugcca aaauggacuc cacagcuaau gagguugagg ccgugaaggu ccauagcuuu     1320

ccuacccuua aauucuuccc cgcuuccgcc gaucgcaccg ugaucgacua caacggcgaa     1380

agaacacugg auggguuuaa gaaguuccuc gagucuggag gccaggacgg ggcgggagau     1440

gacgaugacc uggaagaucu ggaggaagcc gaggagcccg acauggaaga ggaugacgau     1500

cagaaagcug ucaaggacga acucuga                                         1527


<210>  7720
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       PDI/PDIA__Homo_sapiens__AAC13652

<400>  7720
augcuaagaa gagcucuauu augucuagca guugcggcac uagucagggc ugacgcacca       60

gaagaagaag aucauguacu aguauuacga aaaagcaauu ucgcagaagc ucuagcagca      120

cacaaauacc ucuuaguaga auucuacgca ccauggugug gacauugcaa agcauuagca      180

cccgaauaug ccaaagcagc aggaaaacua aaggcagaag gaagcgaaau aagauuagcc      240

aaaguagaug caacagaaga aagcgacuua gcacaacaau auggaguccg aggauaucca      300

acaauaaaau uuuuuagaaa uggagauacc gcaucaccaa aagaauauac agcagguaga      360

gaagcagaug acauugucaa uuggcuaaaa aaaagaacag gcccagcugc cacaacacua      420

ccggacggag cagcggcaga auccuuagua gaaucaucag aaguagcagu aaucggauuc      480

uucaaagaug uugaaagcga uucagcaaaa caauuuuuac aagccgcaga agcaauugau      540

gauauaccau uuggaauaac uucaaacagu gacgucuuca guaaauauca auuagauaaa      600

gaugguguug uacuauucaa aaaauucgac gaaggaagaa auaacuucga aggagaagug      660

acaaaagaaa aucuucuaga cuucauaaag cauaaccaac uaccauuagu aauugaauuu      720

acagaacaaa cagcuccaaa aauauuugga ggagaaauaa aaacacauau acuauuauuc      780

uuaccaaaaa guguaucaga cuaugacggu aaacuaagua acuuuaaaac ugcagcagaa      840

aguuuuaaag gaaaaauauu auuuauauuu auugauagug accauacuga uaaccaacga      900

auacuagaau ucuuuggauu aaaaaaagaa gaauguccgg cagucagacu cauaacauua      960

gaagaagaaa ugacaaaaua caaaccagaa agugaggaau ugacagcaga aagaauaaca     1020

gaauucuguc acagauuccu agaaggaaaa auaaaaccac auuuaauguc acaagaacua     1080

ccagaggauu gggacaaaca acccguaaaa guauuaguag gaaaaaacuu ugaagaugua     1140

gcauucgacg aaaaaaaaaa cguguuugua gaauuuuaug caccauggug uggacauugu     1200

aaacaacuag ccccuauaug ggauaaacua ggagaaacau acaaagacca ugaaaacaua     1260

guaauagcaa aaauggacuc aacagcuaau gaagucgaag caguaaaagu acacucguuu     1320

ccaacguuaa aauuuuuucc agcaucagca gaucguacag uaauagacua caauggagaa     1380

agaacauuag acggauuuaa aaaauucuua gaaagcggag gacaggacgg ugcaggcgau     1440

gaugaugacc uugaagauuu agaagaagcu gaagaaccag auauggaaga agacgaugac     1500

caaaaagcag uaaaagacga acuuuaa                                         1527


<210>  7721
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__Q6YPB0

<400>  7721

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asn Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Asp Gly Leu Val Asn 
        275                 280                 285             


Val Gly Trp Met Asp Cys Ala Thr Gln Asp Asn Leu Cys Lys Ser Leu 
    290                 295                 300                 


Asp Ile Thr Thr Ser Thr Thr Ala Tyr Phe Pro Pro Gly Ala Thr Leu 
305                 310                 315                 320 


Asn Asn Lys Glu Lys Asn Ser Ile Leu Leu Leu His 
                325                 330         


<210>  7722
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__AAG32626

<400>  7722
augggagucu gguuaaauaa agaugacuau aucagagacu ugaaaaggau cauucucugu       60

uuucugauag uguauauggc cauuuuagug ggcacagauc aggauuuuua caguuuacuu      120

ggagugucca aaacugcaag caguagagaa auaagacaag cuuucaagaa auuggcauug      180

aaguuacauc cugauaaaaa cccgaauaac ccaaaugcac auggcaauuu uuuaaaaaua      240

aauagagcau augaaguacu caaagaugaa gaucuacgga aaaaguauga caaauaugga      300

gaaaagggac uugaggauaa ucaagguggc caguaugaaa gcuggaacua uuaucguuau      360

gauuuuggua uuuaugauga ugauccugaa aucauaacau uggaaagaag agaauuugau      420

gcugcuguua auucuggaga acugugguuu guaaauuuuu acuccccagg cuguucacac      480

ugccaugauu uagcucccac auggagagac uuugcuaaag aaguggaugg guuacuucga      540

auuggagcug uuaacugugg ugaugauaga augcuuugcc gaaugaaagg agucaacagc      600

uaucccaguc ucuucauuuu ucggucugga auggccccag ugaaauauca uggagacaga      660

ucaaaggaga guuuagugag uuuugcaaug cagcauguua gaaguacagu gacagaacuu      720

uggacaggaa auuuugucaa cuccauacaa acugcuuuug cugcugguau uggcuggcug      780

aucacuuuuu guucaaaagg aggagauugu uugacuucac agacacgacu caggcuuagu      840

ggcauguugg auggucuugu uaauguagga uggauggacu gugccaccca ggauaaccuu      900

uguaaaagcu uagauauuac aacaaguacu acugcuuauu uuccuccugg agccacuuua      960

aauaacaaag agaaaaacag uauuuugcug cuucauuga                             999


<210>  7723
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7723
augggcgugu ggcugaacaa ggacgacuac auccgcgacc ucaagcggau cauccugugc       60

uuccugaucg ucuacauggc cauccucgug gggaccgacc aggacuucua cagccugcug      120

ggcgugucca agaccgccag cucccgcgag auccggcagg cguucaagaa gcucgcccug      180

aagcugcacc ccgacaagaa cccgaacaac cccaacgccc acgggaacuu ccucaagauc      240

aaccgcgccu acgagguccu gaaggacgag gaccugcgga agaaguacga caaguacggc      300

gagaaggggc ucgaggacaa ccagggcggc caguacgaga gcuggaacua cuaccgcuac      360

gacuucggga ucuacgacga cgaccccgag aucaucacgc uggagcggcg cgaguucgac      420

gccgcgguga acuccggcga gcugugguuc gugaacuucu acagccccgg gugcucccac      480

ugccacgacc ucgccccgac cuggcgggac uucgccaagg aggucgacgg ccugcugcgc      540

aucggggccg ugaacugcgg cgacgaccgg augcucugcc gcaugaaggg cgugaacagc      600

uaccccuccc uguucaucuu ccggagcggg auggcgcccg ucaaguacca cggcgaccgc      660

uccaaggaga gccugguguc cuucgccaug cagcacgugc ggagcaccgu caccgagcuc      720

uggacgggga acuucgugaa cuccauccag accgccuucg ccgccggcau cggcuggcug      780

aucaccuucu gcagcaaggg cggggacugc cugaccuccc agacgcgccu ccggcugagc      840

gggaugcugg acggccucgu gaacgucggg uggauggacu gcgcgaccca ggacaaccug      900

ugcaaguccc uggacaucac caccagcacg accgccuacu ucccgcccgg cgccacccuc      960

aacaacaagg agaagaacag cauccugcug cuccacuga                             999


<210>  7724
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7724
augggcgucu ggcucaacaa ggacgacuac auccgcgacc ucaagcgcau cauccucugc       60

uuccucaucg ucuacauggc cauccucguc ggcaccgacc aggacuucua cucccuccuc      120

ggcgucucca agaccgccuc cucccgcgag auccgccagg ccuucaagaa gcucgcccuc      180

aagcuccacc ccgacaagaa ccccaacaac cccaacgccc acggcaacuu ccucaagauc      240

aaccgcgccu acgagguccu caaggacgag gaccuccgca agaaguacga caaguacggc      300

gagaagggcc ucgaggacaa ccagggcggc caguacgagu ccuggaacua cuaccgcuac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc ucgagcgccg cgaguucgac      420

gccgccguca acuccggcga gcucugguuc gucaacuucu acucccccgg cugcucccac      480

ugccacgacc ucgcccccac cuggcgcgac uucgccaagg aggucgacgg ccuccuccgc      540

aucggcgccg ucaacugcgg cgacgaccgc augcucugcc gcaugaaggg cgucaacucc      600

uaccccuccc ucuucaucuu ccgcuccggc auggcccccg ucaaguacca cggcgaccgc      660

uccaaggagu cccucgucuc cuucgccaug cagcacgucc gcuccaccgu caccgagcuc      720

uggaccggca acuucgucaa cuccauccag accgccuucg ccgccggcau cggcuggcuc      780

aucaccuucu gcuccaaggg cggcgacugc cucaccuccc agacccgccu ccgccucucc      840

ggcaugcucg acggccucgu caacgucggc uggauggacu gcgccaccca ggacaaccuc      900

ugcaaguccc ucgacaucac caccuccacc accgccuacu ucccccccgg cgccacccuc      960

aacaacaagg agaagaacuc cauccuccuc cuccacuga                             999


<210>  7725
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7725
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaaaggau uauacuuugc       60

uuccugaucg ucuauauggc cauuuugguu gggaccgauc aggacuuuua cagcuuacug      120

ggagugucca agacagcuuc uucacgggag auccgccaag cauucaaaaa gcuagcccuc      180

aaacugcacc ccgauaagaa uccuaacaau ccaaacgcgc augguaauuu ucuuaagauu      240

aaccgagcuu augaaguacu gaaagacgag gauuugcgua agaaauacga caaguauggc      300

gaaaaagggc ucgaggauaa ucagggaggc caguacgaaa guuggaacua uuacagauac      360

gacuucggua ucuaugauga cgauccggag auaaucacuc uggagaggcg ggaauuugac      420

gccgcaguga auagcgggga gcugugguuc gucaacuuuu acucccccgg auguucucac      480

ugccaugacc ucgccccuac guggcgcgau uucgcuaagg aaguggacgg cuuacugaga      540

auuggcgcag uuaauugugg ggaugacagg augcuuugcc ggaugaaggg agugaacucg      600

uauccaucau uguuuaucuu ccgcagcggu auggcccccg ucaaauacca cggcgaucga      660

aguaaggagu cccugguguc uuuugcuaug cagcauguaa gaagcaccgu uacagagcua      720

uggacuggga auuucgugaa cuccauucaa accgccuuug cggcaggaau cggcuggcuc      780

auaacauucu guucaaaagg uggggacugc cugaccaguc agacuaggcu ucggcugagc      840

ggaauguugg auggccucgu caaugugggc uggauggacu gugccacaca ggauaaccug      900

ugcaagucuu uagacauuac cacguccacu accgcuuauu ucccuccagg ggccacacug      960

aacaauaaag aaaagaacuc aauccuccuu cugcacuga                             999


<210>  7726
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7726
augggcgugu ggcugaacaa ggacgacuac aucagagacc ugaagagaau cauccugugc       60

uuccugaucg uguacauggc cauccuggug ggcaccgacc aggacuucua cagccugcug      120

ggcgugagca agaccgccag cagcagagag aucagacagg ccuucaagaa gcuggcccug      180

aagcugcacc ccgacaagaa ccccaacaac cccaacgccc acggcaacuu ccugaagauc      240

aacagagccu acgaggugcu gaaggacgag gaccugagaa agaaguacga caaguacggc      300

gagaagggcc uggaggacaa ccagggcggc caguacgaga gcuggaacua cuacagauac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc uggagagaag agaguucgac      420

gccgccguga acagcggcga gcugugguuc gugaacuucu acagccccgg cugcagccac      480

ugccacgacc uggcccccac cuggagagac uucgccaagg agguggacgg ccugcugaga      540

aucggcgccg ugaacugcgg cgacgacaga augcugugca gaaugaaggg cgugaacagc      600

uaccccagcc uguucaucuu cagaagcggc auggcccccg ugaaguacca cggcgacaga      660

agcaaggaga gccuggugag cuucgccaug cagcacguga gaagcaccgu gaccgagcug      720

uggaccggca acuucgugaa cagcauccag accgccuucg ccgccggcau cggcuggcug      780

aucaccuucu gcagcaaggg cggcgacugc cugaccagcc agaccagacu gagacugagc      840

ggcaugcugg acggccuggu gaacgugggc uggauggacu gcgccaccca ggacaaccug      900

ugcaagagcc uggacaucac caccagcacc accgccuacu ucccccccgg cgccacccug      960

aacaacaagg agaagaacag cauccugcug cugcacuga                             999


<210>  7727
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7727
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaacggau uauccugugc       60

uuccuuauug ucuauauggc cauccugguu gggaccgauc aggacuuuua cagccuccug      120

ggagugucca agacagcuuc uagccgcgag auuagacaag ccuucaaaaa gcuggcgcuu      180

aaacuccacc ccgauaagaa uccuaacaau ccgaacgcuc auggcaauuu ucugaagauc      240

aaccgggccu augaagugcu gaaagacgag gaucuccgca agaaauacga caaguauggg      300

gaaaaaggac uggaggauaa ucagggcggg caguacgaau ccuggaacua uuacagauac      360

gacuucggaa ucuaugauga cgaucccgag auuaucacgc uugagcggcg cgaauuugac      420

gccgcuguca auucuggcga gcugugguuc gugaacuuuu acagcccugg cuguucccac      480

ugccaugacc ucgcccccac cuggagagau uucgcuaagg aaguugacgg gcugcuucgg      540

auuggagccg ugaauugugg cgaugaccgc augcugugca gaaugaaggg ggucaacucu      600

uauccuagcc ucuuuaucuu ccgguccgga auggcgcccg ugaaauacca cggcgaucgc      660

agcaaggagu cucugguuuc cuuugccaug cagcauguga gaagcacagu caccgagcug      720

uggacaggga auuucgugaa cucuauucaa accgcuuuug ccgcuggaau cggcuggcuc      780

auuacauucu guuccaaagg cggggacugc cugaccagcc agacgcggcu ucgccugucu      840

ggaaugcucg auggccuggu gaaugucggg uggauggacu gugccaccca ggauaaccuu      900

ugcaaguccc uggacaucac aaccagcaca accgcguauu ucccuccggg agccacgcuc      960

aacaauaaag aaaagaacuc cauccugcug cuccacuga                             999


<210>  7728
<211>  999
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       PDI/PDIA__Homo_sapiens__AAG32626

<400>  7728
augggaguau ggcuaaacaa agacgauuac auacgagauc uaaaaagaau aauauuaugc       60

uuuuuaauag uauauauggc aauauuagua ggaacagacc aagauuucua uaguuuauua      120

gguguaucaa aaacagcauc gagcagagaa auaagacaag cauuuaaaaa acuagcacua      180

aaacuacauc cagauaaaaa uccaaauaau ccaaacgcac acggaaacuu ucuaaaaaua      240

aauagagcau augaaguauu aaaagaugaa gaucuaagaa aaaaauacga uaaguaugga      300

gaaaaagguc uagaagacaa ccaaggagga caauacgaaa gcuggaauua cuaccgauac      360

gauuucggua uauaugacga ugacccagaa auaauaacau uagaaagaag agaauucgac      420

gcagcaguaa acucuggaga acuaugguuc guuaacuuuu acucucccgg auguucacac      480

ugucacgauu uagcaccaac auggagagac uuugcaaaag aaguugacgg auuauuaaga      540

auaggagcag uaaacugcgg agacgauaga augcuauguc gaaugaaagg aguaaauagc      600

uacccaaguc uauuuauauu cagaucagga auggcaccag uaaaauacca cggcgauaga      660

ucaaaagaaa gcuuaguauc auucgcaaug caacacguaa gaucgacagu aacagaacua      720

uggacaggaa acuuuguaaa uagcauacaa acugcauuug cagcuggaau aggauggcua      780

auaacauuuu guucaaaagg aggagauugc uuaacaucuc aaacaagacu aagacuauca      840

ggaauguuag acggacuagu aaacguagga uggauggauu gugcuacaca agacaauuua      900

uguaaaaguu uagauauaac aacaucaaca acagcauauu uuccaccagg agcaacucua      960

aauaacaaag aaaaaaacuc gauacuauua uuacacuaa                             999


<210>  7729
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__Q71S60

<400>  7729

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Ser Leu 
                165                 170                 175     


Arg 
    


<210>  7730
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7730
augggagucu gguuaaauaa agaugacuau aucagagacu ugaaaaggau cauucucugu       60

uuucugauag uguauauggc cauuuuagug ggcacagauc aggauuuuua caguuuacuu      120

ggagugucca aaacugcaag caguagagaa auaagacaag cuuucaagaa auuggcauug      180

aaguuacauc cugauaaaaa cccgaauaac ccaaaugcac auggcgauuu uuuaaaaaua      240

aauagagcau augaaguacu caaagaugaa gaucuacgga aaaaguauga caaauaugga      300

gaaaagggac uugaggauaa ucaagguggc caguaugaaa gcuggaacua uuaucguuau      360

gauuuuggua uuuaugauga ugauccugaa aucauaacau uggaaagaag agaauuugau      420

gcugcuguua auucuggaga acugugguuu guaaauuuuu acuccccagg cuguucacac      480

ugccaugauu uagcucccac auggagagac uuugccaaag aaucccugag auaa            534


<210>  7731
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7731
augggcgugu ggcugaacaa ggacgacuac auccgcgacc ucaagcggau cauccugugc       60

uuccugaucg ucuacauggc cauccucgug gggaccgacc aggacuucua cagccugcug      120

ggcgugucca agaccgccag cucccgcgag auccggcagg cguucaagaa gcucgcccug      180

aagcugcacc ccgacaagaa cccgaacaac cccaacgccc acggggacuu ccucaagauc      240

aaccgcgccu acgagguccu gaaggacgag gaccugcgga agaaguacga caaguacggc      300

gagaaggggc ucgaggacaa ccagggcggc caguacgaga gcuggaacua cuaccgcuac      360

gacuucggga ucuacgacga cgaccccgag aucaucacgc uggagcggcg cgaguucgac      420

gccgcgguga acuccggcga gcugugguuc gugaacuucu acagccccgg gugcucccac      480

ugccacgacc ucgccccgac cuggcgggac uucgccaagg agagccugcg cuga            534


<210>  7732
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7732
augggcgucu ggcucaacaa ggacgacuac auccgcgacc ucaagcgcau cauccucugc       60

uuccucaucg ucuacauggc cauccucguc ggcaccgacc aggacuucua cucccuccuc      120

ggcgucucca agaccgccuc cucccgcgag auccgccagg ccuucaagaa gcucgcccuc      180

aagcuccacc ccgacaagaa ccccaacaac cccaacgccc acggcgacuu ccucaagauc      240

aaccgcgccu acgagguccu caaggacgag gaccuccgca agaaguacga caaguacggc      300

gagaagggcc ucgaggacaa ccagggcggc caguacgagu ccuggaacua cuaccgcuac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc ucgagcgccg cgaguucgac      420

gccgccguca acuccggcga gcucugguuc gucaacuucu acucccccgg cugcucccac      480

ugccacgacc ucgcccccac cuggcgcgac uucgccaagg agucccuccg cuga            534


<210>  7733
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7733
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaaaggau uauacuuugc       60

uuccugaucg ucuauauggc cauuuugguu gggaccgauc aggacuuuua cagcuuacug      120

ggagugucca agacagcuuc uucacgggag auccgccaag cauucaaaaa gcuagcccuc      180

aaacugcacc ccgauaagaa uccuaacaau ccaaacgcgc auggugacuu ucuuaagauu      240

aaucgagcuu augaaguacu gaaagaugag gacuugcgua agaaauacga uaaguauggc      300

gaaaaagggc ucgaggacaa ccagggaggc caguacgaaa guuggaauua uuacagauac      360

gauuucggua ucuaugacga ugacccggag auaaucacuc uggagaggcg ggaauuugac      420

gccgcaguga acagcgggga gcugugguuc gucaauuuuu acucccccgg auguucucac      480

ugccaugauc ucgccccuac guggcgcgac uucgcuaagg aaucguuaag auga            534


<210>  7734
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7734
augggcgugu ggcugaacaa ggacgacuac aucagagacc ugaagagaau cauccugugc       60

uuccugaucg uguacauggc cauccuggug ggcaccgacc aggacuucua cagccugcug      120

ggcgugagca agaccgccag cagcagagag aucagacagg ccuucaagaa gcuggcccug      180

aagcugcacc ccgacaagaa ccccaacaac cccaacgccc acggcgacuu ccugaagauc      240

aacagagccu acgaggugcu gaaggacgag gaccugagaa agaaguacga caaguacggc      300

gagaagggcc uggaggacaa ccagggcggc caguacgaga gcuggaacua cuacagauac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc uggagagaag agaguucgac      420

gccgccguga acagcggcga gcugugguuc gugaacuucu acagccccgg cugcagccac      480

ugccacgacc uggcccccac cuggagagac uucgccaagg agagccugag auga            534


<210>  7735
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7735
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaacggau uauccugugc       60

uuccuuauug ucuauauggc cauccugguu gggaccgauc aggacuuuua cagccuccug      120

ggagugucca agacagcuuc uagccgcgag auuagacaag ccuucaaaaa gcuggcgcuu      180

aaacuccacc ccgauaagaa uccuaacaau ccgaacgcuc auggcgacuu ucugaagauc      240

aaucgggccu augaagugcu gaaagaugag gaccuccgca agaaauacga uaaguauggg      300

gaaaaaggac uggaggacaa ccagggcggg caguacgaau ccuggaauua uuacagauac      360

gauuucggaa ucuaugacga ugaccccgag auuaucacgc uugagcggcg cgaauuugac      420

gccgcuguca acucuggcga gcugugguuc gugaauuuuu acagcccugg cuguucccac      480

ugccaugauc ucgcccccac cuggagagac uucgcuaagg aaucucugcg guga            534


<210>  7736
<211>  534
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       PDI/PDIA__Homo_sapiens__AAQ14565

<400>  7736
augggaguau ggcuaaacaa agacgacuac auaagagacu uaaaaagaau aauacuaugc       60

uuccuaauag uauacauggc aauacuagua ggaacagacc aagacuucua cagccuacua      120

ggaguaucaa aaacagcauc aucaagagaa auacgacaag cauucaaaaa auuagcacua      180

aaauuacauc cagacaaaaa cccaaacaac ccaaacgcac acggagacuu ccuaaaaaua      240

aacagagcau acgaaguauu aaaagacgaa gacuuaagaa aaaaauacga caaauacgga      300

gaaaaaggac uagaagacaa ccaaggagga caauacgaau cauggaacua cuacagauac      360

gacuucggaa uauacgacga cgacccagaa auaauaacac uagaaagaag agaauucgac      420

gcagcaguaa acucaggaga acuaugguuc guaaacuucu acucaccagg augcagucac      480

ugccacgacc uagcaccaac auggagagac uucgcaaaag aaucacuacg auaa            534


<210>  7737
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__B0LPE5

<400>  7737

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 






<210>  7738
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__ABY87524

<400>  7738
augagcgacg uggcuauugu gaaggagggu uggcugcaca aacgagggga guacaucaag       60

accuggcggc cacgcuacuu ccuccucaag aaugauggca ccuucauugg cuacaaggag      120

cggccgcagg auguggacca acgugaggcu ccccucaaca acuucucugu ggcgcagugc      180

cagcugauga agacggagcg gccccggccc aacaccuuca ucauccgcug ccugcagugg      240

accacuguca ucgaacgcac cuuccaugug gagacuccug aggagcggga ggaguggaca      300

accgccaucc agacuguggc ugacggccuc aagaagcagg aggaggagga gauggacuuc      360

cggucgggcu cacccaguga caacucaggg gcugaagaga uggagguguc ccuggccaag      420

cccaagcacc gcgugaccau gaacgaguuu gaguaccuga agcugcuggg caagggcacu      480

uucggcaagg ugauccuggu gaaggagaag gccacaggcc gcuacuacgc caugaagauc      540

cucaagaagg aagucaucgu ggccaaggac gagguggccc acacacucac cgagaaccgc      600

guccugcaga acuccaggca ccccuuccuc acagcccuga aguacucuuu ccagacccac      660

gaccgccucu gcuuugucau ggaguacgcc aacgggggcg agcuguucuu ccaccugucc      720

cgggagcgug uguucuccga ggaccgggcc cgcuucuaug gcgcugagau ugugucagcc      780

cuggacuacc ugcacucgga gaagaacgug guguaccggg accucaagcu ggagaaccuc      840

augcuggaca aggacgggca cauuaagauc acagacuucg ggcugugcaa ggaggggauc      900

aaggacggug ccaccaugaa gaccuuuugc ggcacaccug aguaccuggc ccccgaggug      960

cuggaggaca augacuacgg ccgugcagug gacugguggg ggcugggcgu ggucauguac     1020

gagaugaugu gcggucgccu gcccuucuac aaccaggacc augagaagcu uuuugagcuc     1080

auccucaugg aggagauccg cuucccgcgc acgcuugguc ccgaggccaa guccuugcuu     1140

ucagggcugc ucaagaagga ccccaagcag aggcuuggcg ggggcuccga ggacgccaag     1200

gagaucaugc agcaucgcuu cuuugccggu aucguguggc agcacgugua cgagaagaag     1260

cucagcccac ccuucaagcc ccaggucacg ucggagacug acaccaggua uuuugaugag     1320

gaguucacgg cccagaugau caccaucaca ccaccugacc aagaugacag cauggagugu     1380

guggacagcg agcgcaggcc ccacuucccc caguucuccu acucggccag cggcacggcc     1440

uga                                                                   1443


<210>  7739
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Akt__Homo_sapiens__ABY87524

<400>  7739
augagcgacg uggccaucgu caaggagggc uggcugcaca agcgcgggga guacaucaag       60

accuggcggc cccgcuacuu ccuccugaag aacgacggca ccuucaucgg guacaaggag      120

cggccgcagg acguggacca gcgcgaggcg ccccugaaca acuucuccgu ggcccagugc      180

cagcucauga agacggagcg gccccgcccc aacaccuuca ucauccggug ccugcagugg      240

accaccguca ucgagcgcac guuccacgug gagaccccgg aggagcggga ggaguggacc      300

accgccaucc agacgguggc cgacggccug aagaagcagg aggaggagga gauggacuuc      360

cgcagcgggu cccccagcga caacuccggc gccgaggaga uggaggucag ccucgccaag      420

cccaagcacc gggugaccau gaacgaguuc gaguaccuga agcugcucgg caaggggacc      480

uucggcaagg ugauccuggu caaggagaag gcgaccgggc gcuacuacgc caugaagauc      540

cugaagaagg aggugaucgu ggccaaggac gaggucgccc acacgcucac cgagaaccgg      600

gugcugcaga acucccgcca ccccuuccug accgcgcuca aguacagcuu ccagacccac      660

gaccggcugu gcuucgugau ggaguacgcc aacggcgggg agcuguucuu ccaccucucc      720

cgcgagcggg ucuucagcga ggaccgcgcc cgguucuacg gcgccgagau cguguccgcc      780

cuggacuacc ugcacagcga gaagaacgug gucuaccgcg accucaagcu ggagaaccug      840

augcucgaca aggacggcca caucaagauc acggacuucg ggcugugcaa ggagggcauc      900

aaggacgggg cgaccaugaa gaccuucugc ggcaccccgg aguaccuggc ccccgaggug      960

cucgaggaca acgacuacgg ccgggccgug gacugguggg ggcugggcgu cgugauguac     1020

gagaugaugu gcgggcgccu gcccuucuac aaccaggacc acgagaagcu guucgagcuc     1080

auccugaugg aggagauccg cuucccccgg acgcucggcc cggaggccaa gucccugcug     1140

agcgggcucc ugaagaagga ccccaagcag cgccugggcg gcggguccga ggacgccaag     1200

gagaucaugc agcaccgguu cuucgcgggc aucguguggc agcacgucua cgagaagaag     1260

cucagcccgc ccuucaagcc ccaggugacc uccgagaccg acacccgcua cuucgacgag     1320

gaguucacgg cccagaugau caccaucacc ccgcccgacc aggacgacag cauggagugc     1380

gucgacuccg agcggcgccc ccacuucccc caguucagcu acagcgccuc cgggaccgcc     1440

uga                                                                   1443


<210>  7740
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Akt__Homo_sapiens__ABY87524

<400>  7740
auguccgacg ucgccaucgu caaggagggc uggcuccaca agcgcggcga guacaucaag       60

accuggcgcc cccgcuacuu ccuccucaag aacgacggca ccuucaucgg cuacaaggag      120

cgcccccagg acgucgacca gcgcgaggcc ccccucaaca acuucuccgu cgcccagugc      180

cagcucauga agaccgagcg cccccgcccc aacaccuuca ucauccgcug ccuccagugg      240

accaccguca ucgagcgcac cuuccacguc gagacccccg aggagcgcga ggaguggacc      300

accgccaucc agaccgucgc cgacggccuc aagaagcagg aggaggagga gauggacuuc      360

cgcuccggcu cccccuccga caacuccggc gccgaggaga uggaggucuc ccucgccaag      420

cccaagcacc gcgucaccau gaacgaguuc gaguaccuca agcuccucgg caagggcacc      480

uucggcaagg ucauccucgu caaggagaag gccaccggcc gcuacuacgc caugaagauc      540

cucaagaagg aggucaucgu cgccaaggac gaggucgccc acacccucac cgagaaccgc      600

guccuccaga acucccgcca ccccuuccuc accgcccuca aguacuccuu ccagacccac      660

gaccgccucu gcuucgucau ggaguacgcc aacggcggcg agcucuucuu ccaccucucc      720

cgcgagcgcg ucuucuccga ggaccgcgcc cgcuucuacg gcgccgagau cgucuccgcc      780

cucgacuacc uccacuccga gaagaacguc gucuaccgcg accucaagcu cgagaaccuc      840

augcucgaca aggacggcca caucaagauc accgacuucg gccucugcaa ggagggcauc      900

aaggacggcg ccaccaugaa gaccuucugc ggcacccccg aguaccucgc ccccgagguc      960

cucgaggaca acgacuacgg ccgcgccguc gacugguggg gccucggcgu cgucauguac     1020

gagaugaugu gcggccgccu ccccuucuac aaccaggacc acgagaagcu cuucgagcuc     1080

auccucaugg aggagauccg cuucccccgc acccucggcc ccgaggccaa gucccuccuc     1140

uccggccucc ucaagaagga ccccaagcag cgccucggcg gcggcuccga ggacgccaag     1200

gagaucaugc agcaccgcuu cuucgccggc aucgucuggc agcacgucua cgagaagaag     1260

cucucccccc ccuucaagcc ccaggucacc uccgagaccg acacccgcua cuucgacgag     1320

gaguucaccg cccagaugau caccaucacc ccccccgacc aggacgacuc cauggagugc     1380

gucgacuccg agcgccgccc ccacuucccc caguucuccu acuccgccuc cggcaccgcc     1440

uga                                                                   1443


<210>  7741
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Akt__Homo_sapiens__ABY87524

<400>  7741
augagcgacg uggccaucgu caaggagggc uggcugcaca aaagagggga auacauuaag       60

accuggaggc cccgguauuu ccuccuuaaa aacgauggaa cauuuauagg uuacaaggag      120

cgcccucagg acguugauca acgagaagcu ccacugaaua acuucuccgu ggcacagugc      180

caguugauga aaacugagcg uccgagaccc aauacguuua ucauuaggug uuuacagugg      240

accacaguaa ucgaacggac uuuccaugug gagaccccug aggaacgcga ggaauggaca      300

accgccauuc aaacugucgc ggacggccug aagaagcagg aggaggaaga gauggauuuu      360

agaucugggu caccaaguga caacagcgga gcugaagaga uggaaguguc ccuagccaaa      420

cccaagcaca ggguuacaau gaaugaguuc gaguaucuca aacugcuugg caaggguacc      480

uuugggaaag ugauccuggu caaggaaaag gcaacgggac gguacuaugc caugaaaaua      540

uugaagaaag aggugaucgu agcuaaggau gaaguugcac auacucucac cgagaaccgc      600

gugcugcaaa auucucgaca cccuuuccug acagcccuca aauacucguu ucagacucau      660

gacagauuau gcuucgucau ggaauaugcu aacggcggcg agcuguuuuu ccaccuuuca      720

agggagcggg uguuuagcga agaucgugcc cgcuucuacg gggcggagau ugugagugca      780

uuggacuacc ugcacuccga aaagaauguc guuuauagag aucuaaaacu cgagaaccug      840

augcuugaca aggauggaca uaucaagauu accgacuucg gucuguguaa agaaggcauc      900

aaggacgggg ccacaaugaa aaccuuuugc ggaacgccag aguacuuggc ucccgaggug      960

cucgaagaua augacuaugg cagggccgua gauugguggg gucugggggu ggucauguac     1020

gagaugaugu guggacgguu accuuucuau aaccaggacc acgaaaagcu guuugagcuc     1080

auacuuaugg aggaaauucg auucccacgc acucugggcc cggaggcaaa aucuuugcua     1140

agcggccugc ucaagaagga ucccaaacag agacuugggg gagguuccga agacgcuaag     1200

gagaucaugc agcauagguu uuucgccggc auuguguggc agcacguuua cgaaaagaaa     1260

cugucaccuc cauuuaaacc ccaagugaca agugagaccg auacucggua uuucgacgag     1320

gaauuuacag cgcagaugau caccaucacg ccuccagauc aggacgauag cauggagugc     1380

gucgacucug aacgcagacc ccacuucccg caauuuuccu acucagccag cgggaccgca     1440

uga                                                                   1443


<210>  7742
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Akt__Homo_sapiens__ABY87524

<400>  7742
augagcgacg uggccaucgu gaaggagggc uggcugcaca agagaggcga guacaucaag       60

accuggagac ccagauacuu ccugcugaag aacgacggca ccuucaucgg cuacaaggag      120

agaccccagg acguggacca gagagaggcc ccccugaaca acuucagcgu ggcccagugc      180

cagcugauga agaccgagag acccagaccc aacaccuuca ucaucagaug ccugcagugg      240

accaccguga ucgagagaac cuuccacgug gagacccccg aggagagaga ggaguggacc      300

accgccaucc agaccguggc cgacggccug aagaagcagg aggaggagga gauggacuuc      360

agaagcggca gccccagcga caacagcggc gccgaggaga uggaggugag ccuggccaag      420

cccaagcaca gagugaccau gaacgaguuc gaguaccuga agcugcuggg caagggcacc      480

uucggcaagg ugauccuggu gaaggagaag gccaccggca gauacuacgc caugaagauc      540

cugaagaagg aggugaucgu ggccaaggac gagguggccc acacccugac cgagaacaga      600

gugcugcaga acagcagaca ccccuuccug accgcccuga aguacagcuu ccagacccac      660

gacagacugu gcuucgugau ggaguacgcc aacggcggcg agcuguucuu ccaccugagc      720

agagagagag uguucagcga ggacagagcc agauucuacg gcgccgagau cgugagcgcc      780

cuggacuacc ugcacagcga gaagaacgug guguacagag accugaagcu ggagaaccug      840

augcuggaca aggacggcca caucaagauc accgacuucg gccugugcaa ggagggcauc      900

aaggacggcg ccaccaugaa gaccuucugc ggcacccccg aguaccuggc ccccgaggug      960

cuggaggaca acgacuacgg cagagccgug gacugguggg gccugggcgu ggugauguac     1020

gagaugaugu gcggcagacu gcccuucuac aaccaggacc acgagaagcu guucgagcug     1080

auccugaugg aggagaucag auuccccaga acccugggcc ccgaggccaa gagccugcug     1140

agcggccugc ugaagaagga ccccaagcag agacugggcg gcggcagcga ggacgccaag     1200

gagaucaugc agcacagauu cuucgccggc aucguguggc agcacgugua cgagaagaag     1260

cugagccccc ccuucaagcc ccaggugacc agcgagaccg acaccagaua cuucgacgag     1320

gaguucaccg cccagaugau caccaucacc ccccccgacc aggacgacag cauggagugc     1380

guggacagcg agagaagacc ccacuucccc caguucagcu acagcgccag cggcaccgcc     1440

uga                                                                   1443


<210>  7743
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Akt__Homo_sapiens__ABY87524

<400>  7743
augagcgacg uggccaucgu caaggagggc uggcugcaca aaagagggga auacauuaag       60

accuggcggc cccgcuauuu ccuccugaaa aacgauggaa cauuuaucgg cuacaaggag      120

agaccucagg acguugauca acgggaagcu ccgcuuaaua acuucuccgu ggcccagugc      180

cagcugauga aaacggagcg ccccagaccu aauaccuuua uuauccggug ucuccagugg      240

acaaccguga uugaacgcac auuccauguc gagacccccg aggaaagaga ggaauggaca      300

accgcgaucc aaacgguggc ugacgggcug aagaagcagg aggaggaaga gauggauuuu      360

cggucuggaa gcccuuccga caacucuggc gccgaagaga uggaaguuag ccuugccaaa      420

cccaagcacc gcgugaccau gaaugaguuc gaguaucuga aacuccuggg gaagggaaca      480

uuuggcaaag ucauccuggu gaaggaaaag gcuaccggca gauacuaugc caugaaaauu      540

cucaagaaag agguuaucgu ggcuaaggau gaagucgccc auacacugac cgagaaccgg      600

gugcuucaaa auucccgcca cccuuuccug acggcgcuca aauacucuuu ucagacacau      660

gacagacugu gcuucgugau ggaauaugcc aacgggggag agcuguuuuu ccaccuuagc      720

cgggagcgcg ucuuuuccga agauagagcu cgguucuacg gcgccgagau uguuagcgcu      780

cucgacuacc ugcacucuga aaagaaugug guguauagag aucugaaacu cgagaaccug      840

augcuugaca aggaugggca uaucaagauu accgacuucg gacuguguaa agaaggcauc      900

aaggacgggg ccacaaugaa aaccuuuugc ggaaccccgg aguaccucgc gcccgagguc      960

cuggaagaua augacuaugg ccgcgccgug gauugguggg gccuuggggu ugugauguac     1020

gagaugaugu guggacggcu gccuuucuau aaccaggacc acgaaaagcu cuuugagcug     1080

auucugaugg aggaaaucag auucccccgc acacucggcc cugaggcuaa aucccugcuu     1140

agcgggcugc ucaagaagga ucccaaacag cggcugggag gcgggucuga agacgccaag     1200

gagaucaugc agcauagauu uuucgcugga auugucuggc agcacgugua cgaaaagaaa     1260

cuuuccccgc cuuuuaaacc ccaaguuacg agcgagaccg auacacgcua uuucgacgag     1320

gaauuuaccg cccagaugau cacaauuacc ccucccgauc aggacgauuc uauggagugc     1380

guggacuccg aacggagacc ccacuucccu caauuuagcu acuccgccuc uggcacggcu     1440

uga                                                                   1443


<210>  7744
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__P31749

<400>  7744

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 






<210>  7745
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__AAH00479

<400>  7745
augagcgacg uggcuauugu gaaggagggu uggcugcaca aacgagggga guacaucaag       60

accuggcggc cacgcuacuu ccuccucaag aaugauggca ccuucauugg cuacaaggag      120

cggccgcagg auguggacca acgugaggcu ccccucaaca acuucucugu ggcgcagugc      180

cagcugauga agacggagcg gccccggccc aacaccuuca ucauccgcug ccugcagugg      240

accacuguca ucgaacgcac cuuccaugug gagacuccug aggagcggga ggaguggaca      300

accgccaucc agacuguggc ugacggccuc aagaagcagg aggaggagga gauggacuuc      360

cggucgggcu cacccaguga caacucaggg gcugaagaga uggagguguc ccuggccaag      420

cccaagcacc gcgugaccau gaacgaguuu gaguaccuga agcugcuggg caagggcacu      480

uucggcaagg ugauccuggu gaaggagaag gccacaggcc gcuacuacgc caugaagauc      540

cucaagaagg aagucaucgu ggccaaggac gagguggccc acacacucac cgagaaccgc      600

guccugcaga acuccaggca ccccuuccuc acagcccuga aguacucuuu ccagacccac      660

gaccgccucu gcuuugucau ggaguacgcc aacgggggcg agcuguucuu ccaccugucc      720

cgggagcgug uguucuccga ggaccgggcc cgcuucuaug gcgcugagau ugugucagcc      780

cuggacuacc ugcacucgga gaagaacgug guguaccggg accucaagcu ggagaaccuc      840

augcuggaca aggacgggca cauuaagauc acagacuucg ggcugugcaa ggaggggauc      900

aaggacggug ccaccaugaa gaccuuuugc ggcacaccug aguaccuggc ccccgaggug      960

cuggaggaca augacuacgg ccgugcagug gacugguggg ggcugggcgu ggucauguac     1020

gagaugaugu gcggucgccu gcccuucuac aaccaggacc augagaagcu uuuugagcuc     1080

auccucaugg aggagauccg cuucccgcgc acgcuugguc ccgaggccaa guccuugcuu     1140

ucagggcugc ucaagaagga ccccaagcag aggcuuggcg ggggcuccga ggacgccaag     1200

gagaucaugc agcaucgcuu cuuugccggu aucguguggc agcacgugua cgagaagaag     1260

cucagcccac ccuucaagcc ccaggucacg ucggagacug acaccaggua uuuugaugag     1320

gaguucacgg cccagaugau caccaucaca ccaccugacc aagaugacag cauggagugu     1380

guggacagcg agcgcaggcc ccacuucccc caguucuccu acucggccag cggcacggcc     1440

uga                                                                   1443


<210>  7746
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Akt__Homo_sapiens__AAH00479

<400>  7746
augagcgacg uggccaucgu caaggagggc uggcugcaca agcgcgggga guacaucaag       60

accuggcggc cccgcuacuu ccuccugaag aacgacggca ccuucaucgg guacaaggag      120

cggccgcagg acguggacca gcgcgaggcg ccccugaaca acuucuccgu ggcccagugc      180

cagcucauga agacggagcg gccccgcccc aacaccuuca ucauccggug ccugcagugg      240

accaccguca ucgagcgcac guuccacgug gagaccccgg aggagcggga ggaguggacc      300

accgccaucc agacgguggc cgacggccug aagaagcagg aggaggagga gauggacuuc      360

cgcagcgggu cccccagcga caacuccggc gccgaggaga uggaggucag ccucgccaag      420

cccaagcacc gggugaccau gaacgaguuc gaguaccuga agcugcucgg caaggggacc      480

uucggcaagg ugauccuggu caaggagaag gcgaccgggc gcuacuacgc caugaagauc      540

cugaagaagg aggugaucgu ggccaaggac gaggucgccc acacgcucac cgagaaccgg      600

gugcugcaga acucccgcca ccccuuccug accgcgcuca aguacagcuu ccagacccac      660

gaccggcugu gcuucgugau ggaguacgcc aacggcgggg agcuguucuu ccaccucucc      720

cgcgagcggg ucuucagcga ggaccgcgcc cgguucuacg gcgccgagau cguguccgcc      780

cuggacuacc ugcacagcga gaagaacgug gucuaccgcg accucaagcu ggagaaccug      840

augcucgaca aggacggcca caucaagauc acggacuucg ggcugugcaa ggagggcauc      900

aaggacgggg cgaccaugaa gaccuucugc ggcaccccgg aguaccuggc ccccgaggug      960

cucgaggaca acgacuacgg ccgggccgug gacugguggg ggcugggcgu cgugauguac     1020

gagaugaugu gcgggcgccu gcccuucuac aaccaggacc acgagaagcu guucgagcuc     1080

auccugaugg aggagauccg cuucccccgg acgcucggcc cggaggccaa gucccugcug     1140

agcgggcucc ugaagaagga ccccaagcag cgccugggcg gcggguccga ggacgccaag     1200

gagaucaugc agcaccgguu cuucgcgggc aucguguggc agcacgucua cgagaagaag     1260

cucagcccgc ccuucaagcc ccaggugacc uccgagaccg acacccgcua cuucgacgag     1320

gaguucacgg cccagaugau caccaucacc ccgcccgacc aggacgacag cauggagugc     1380

gucgacuccg agcggcgccc ccacuucccc caguucagcu acagcgccuc cgggaccgcc     1440

uga                                                                   1443


<210>  7747
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Akt__Homo_sapiens__AAH00479

<400>  7747
auguccgacg ucgccaucgu caaggagggc uggcuccaca agcgcggcga guacaucaag       60

accuggcgcc cccgcuacuu ccuccucaag aacgacggca ccuucaucgg cuacaaggag      120

cgcccccagg acgucgacca gcgcgaggcc ccccucaaca acuucuccgu cgcccagugc      180

cagcucauga agaccgagcg cccccgcccc aacaccuuca ucauccgcug ccuccagugg      240

accaccguca ucgagcgcac cuuccacguc gagacccccg aggagcgcga ggaguggacc      300

accgccaucc agaccgucgc cgacggccuc aagaagcagg aggaggagga gauggacuuc      360

cgcuccggcu cccccuccga caacuccggc gccgaggaga uggaggucuc ccucgccaag      420

cccaagcacc gcgucaccau gaacgaguuc gaguaccuca agcuccucgg caagggcacc      480

uucggcaagg ucauccucgu caaggagaag gccaccggcc gcuacuacgc caugaagauc      540

cucaagaagg aggucaucgu cgccaaggac gaggucgccc acacccucac cgagaaccgc      600

guccuccaga acucccgcca ccccuuccuc accgcccuca aguacuccuu ccagacccac      660

gaccgccucu gcuucgucau ggaguacgcc aacggcggcg agcucuucuu ccaccucucc      720

cgcgagcgcg ucuucuccga ggaccgcgcc cgcuucuacg gcgccgagau cgucuccgcc      780

cucgacuacc uccacuccga gaagaacguc gucuaccgcg accucaagcu cgagaaccuc      840

augcucgaca aggacggcca caucaagauc accgacuucg gccucugcaa ggagggcauc      900

aaggacggcg ccaccaugaa gaccuucugc ggcacccccg aguaccucgc ccccgagguc      960

cucgaggaca acgacuacgg ccgcgccguc gacugguggg gccucggcgu cgucauguac     1020

gagaugaugu gcggccgccu ccccuucuac aaccaggacc acgagaagcu cuucgagcuc     1080

auccucaugg aggagauccg cuucccccgc acccucggcc ccgaggccaa gucccuccuc     1140

uccggccucc ucaagaagga ccccaagcag cgccucggcg gcggcuccga ggacgccaag     1200

gagaucaugc agcaccgcuu cuucgccggc aucgucuggc agcacgucua cgagaagaag     1260

cucucccccc ccuucaagcc ccaggucacc uccgagaccg acacccgcua cuucgacgag     1320

gaguucaccg cccagaugau caccaucacc ccccccgacc aggacgacuc cauggagugc     1380

gucgacuccg agcgccgccc ccacuucccc caguucuccu acuccgccuc cggcaccgcc     1440

uga                                                                   1443


<210>  7748
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Akt__Homo_sapiens__AAH00479

<400>  7748
augagcgacg uggccaucgu caaggagggc uggcugcaca aaagagggga auacauuaag       60

accuggaggc cccgguauuu ccuccuuaaa aacgauggaa cauuuauagg uuacaaggag      120

cgcccucagg acguugauca acgagaagcu ccacugaaua acuucuccgu ggcacagugc      180

caguugauga aaacugagcg uccgagaccc aauacguuua ucauuaggug uuuacagugg      240

accacaguaa ucgaacggac uuuccaugug gagaccccug aggaacgcga ggaauggaca      300

accgccauuc aaacugucgc ggacggccug aagaagcagg aggaggaaga gauggauuuu      360

agaucugggu caccaaguga caacagcgga gcugaagaga uggaaguguc ccuagccaaa      420

cccaagcaca ggguuacaau gaaugaguuc gaguaucuca aacugcuugg caaggguacc      480

uuugggaaag ugauccuggu caaggaaaag gcaacgggac gguacuaugc caugaaaaua      540

uugaagaaag aggugaucgu agcuaaggau gaaguugcac auacucucac cgagaaccgc      600

gugcugcaaa auucucgaca cccuuuccug acagcccuca aauacucguu ucagacucau      660

gacagauuau gcuucgucau ggaauaugcu aacggcggcg agcuguuuuu ccaccuuuca      720

agggagcggg uguuuagcga agaucgugcc cgcuucuacg gggcggagau ugugagugca      780

uuggacuacc ugcacuccga aaagaauguc guuuauagag aucuaaaacu cgagaaccug      840

augcuugaca aggauggaca uaucaagauu accgacuucg gucuguguaa agaaggcauc      900

aaggacgggg ccacaaugaa aaccuuuugc ggaacgccag aguacuuggc ucccgaggug      960

cucgaagaua augacuaugg cagggccgua gauugguggg gucugggggu ggucauguac     1020

gagaugaugu guggacgguu accuuucuau aaccaggacc acgaaaagcu guuugagcuc     1080

auacuuaugg aggaaauucg auucccacgc acucugggcc cggaggcaaa aucuuugcua     1140

agcggccugc ucaagaagga ucccaaacag agacuugggg gagguuccga agacgcuaag     1200

gagaucaugc agcauagguu uuucgccggc auuguguggc agcacguuua cgaaaagaaa     1260

cugucaccuc cauuuaaacc ccaagugaca agugagaccg auacucggua uuucgacgag     1320

gaauuuacag cgcagaugau caccaucacg ccuccagauc aggacgauag cauggagugc     1380

gucgacucug aacgcagacc ccacuucccg caauuuuccu acucagccag cgggaccgca     1440

uga                                                                   1443


<210>  7749
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Akt__Homo_sapiens__AAH00479

<400>  7749
augagcgacg uggccaucgu gaaggagggc uggcugcaca agagaggcga guacaucaag       60

accuggagac ccagauacuu ccugcugaag aacgacggca ccuucaucgg cuacaaggag      120

agaccccagg acguggacca gagagaggcc ccccugaaca acuucagcgu ggcccagugc      180

cagcugauga agaccgagag acccagaccc aacaccuuca ucaucagaug ccugcagugg      240

accaccguga ucgagagaac cuuccacgug gagacccccg aggagagaga ggaguggacc      300

accgccaucc agaccguggc cgacggccug aagaagcagg aggaggagga gauggacuuc      360

agaagcggca gccccagcga caacagcggc gccgaggaga uggaggugag ccuggccaag      420

cccaagcaca gagugaccau gaacgaguuc gaguaccuga agcugcuggg caagggcacc      480

uucggcaagg ugauccuggu gaaggagaag gccaccggca gauacuacgc caugaagauc      540

cugaagaagg aggugaucgu ggccaaggac gagguggccc acacccugac cgagaacaga      600

gugcugcaga acagcagaca ccccuuccug accgcccuga aguacagcuu ccagacccac      660

gacagacugu gcuucgugau ggaguacgcc aacggcggcg agcuguucuu ccaccugagc      720

agagagagag uguucagcga ggacagagcc agauucuacg gcgccgagau cgugagcgcc      780

cuggacuacc ugcacagcga gaagaacgug guguacagag accugaagcu ggagaaccug      840

augcuggaca aggacggcca caucaagauc accgacuucg gccugugcaa ggagggcauc      900

aaggacggcg ccaccaugaa gaccuucugc ggcacccccg aguaccuggc ccccgaggug      960

cuggaggaca acgacuacgg cagagccgug gacugguggg gccugggcgu ggugauguac     1020

gagaugaugu gcggcagacu gcccuucuac aaccaggacc acgagaagcu guucgagcug     1080

auccugaugg aggagaucag auuccccaga acccugggcc ccgaggccaa gagccugcug     1140

agcggccugc ugaagaagga ccccaagcag agacugggcg gcggcagcga ggacgccaag     1200

gagaucaugc agcacagauu cuucgccggc aucguguggc agcacgugua cgagaagaag     1260

cugagccccc ccuucaagcc ccaggugacc agcgagaccg acaccagaua cuucgacgag     1320

gaguucaccg cccagaugau caccaucacc ccccccgacc aggacgacag cauggagugc     1380

guggacagcg agagaagacc ccacuucccc caguucagcu acagcgccag cggcaccgcc     1440

uga                                                                   1443


<210>  7750
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Akt__Homo_sapiens__AAH00479

<400>  7750
augagcgacg uggccaucgu caaggagggc uggcugcaca aaagagggga auacauuaag       60

accuggcggc cccgcuauuu ccuccugaaa aacgauggaa cauuuaucgg cuacaaggag      120

agaccucagg acguugauca acgggaagcu ccgcuuaaua acuucuccgu ggcccagugc      180

cagcugauga aaacggagcg ccccagaccu aauaccuuua uuauccggug ucuccagugg      240

acaaccguga uugaacgcac auuccauguc gagacccccg aggaaagaga ggaauggaca      300

accgcgaucc aaacgguggc ugacgggcug aagaagcagg aggaggaaga gauggauuuu      360

cggucuggaa gcccuuccga caacucuggc gccgaagaga uggaaguuag ccuugccaaa      420

cccaagcacc gcgugaccau gaaugaguuc gaguaucuga aacuccuggg gaagggaaca      480

uuuggcaaag ucauccuggu gaaggaaaag gcuaccggca gauacuaugc caugaaaauu      540

cucaagaaag agguuaucgu ggcuaaggau gaagucgccc auacacugac cgagaaccgg      600

gugcuucaaa auucccgcca cccuuuccug acggcgcuca aauacucuuu ucagacacau      660

gacagacugu gcuucgugau ggaauaugcc aacgggggag agcuguuuuu ccaccuuagc      720

cgggagcgcg ucuuuuccga agauagagcu cgguucuacg gcgccgagau uguuagcgcu      780

cucgacuacc ugcacucuga aaagaaugug guguauagag aucugaaacu cgagaaccug      840

augcuugaca aggaugggca uaucaagauu accgacuucg gacuguguaa agaaggcauc      900

aaggacgggg ccacaaugaa aaccuuuugc ggaaccccgg aguaccucgc gcccgagguc      960

cuggaagaua augacuaugg ccgcgccgug gauugguggg gccuuggggu ugugauguac     1020

gagaugaugu guggacggcu gccuuucuau aaccaggacc acgaaaagcu cuuugagcug     1080

auucugaugg aggaaaucag auucccccgc acacucggcc cugaggcuaa aucccugcuu     1140

agcgggcugc ucaagaagga ucccaaacag cggcugggag gcgggucuga agacgccaag     1200

gagaucaugc agcauagauu uuucgcugga auugucuggc agcacgugua cgaaaagaaa     1260

cuuuccccgc cuuuuaaacc ccaaguuacg agcgagaccg auacacgcua uuucgacgag     1320

gaauuuaccg cccagaugau cacaauuacc ccucccgauc aggacgauuc uauggagugc     1380

guggacuccg aacggagacc ccacuucccu caauuuagcu acuccgccuc uggcacggcu     1440

uga                                                                   1443


<210>  7751
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__P31751

<400>  7751

Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg 
        195                 200                 205             


His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
        275                 280                 285             


Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
    290                 295                 300                 


Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
305                 310                 315                 320 


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                325                 330                 335     


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
            340                 345                 350         


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
        355                 360                 365             


Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
    370                 375                 380                 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
385                 390                 395                 400 


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                405                 410                 415     


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser 
            420                 425                 430         


Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile 
        435                 440                 445             


Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
    450                 455                 460                 


Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
465                 470                 475                 480 


Glu 
    


<210>  7752
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__AAA58364

<400>  7752
augaaugagg ugucugucau caaagaaggc uggcuccaca agcgugguga auacaucaag       60

accuggaggc cacgguacuu ccugcugaag agcgacggcu ccuucauugg guacaaggag      120

aggcccgagg ccccugauca gacucuaccc cccuuaaaca acuucuccgu agcagaaugc      180

cagcugauga agaccgagag gccgcgaccc aacaccuuug ucauacgcug ccugcagugg      240

accacaguca ucgagaggac cuuccacgug gauucuccag acgagaggga ggaguggaug      300

cgggccaucc agauggucgc caacagccuc aagcagcggg ccccaggcga ggaccccaug      360

gacuacaagu guggcucccc cagugacucc uccacgacug aggagaugga aguggcgguc      420

agcaaggcac gggcuaaagu gaccaugaau gacuucgacu aucucaaacu ccuuggcaag      480

ggaaccuuug gcaaagucau ccuggugcgg gagaaggcca cuggccgcua cuacgccaug      540

aagauccugc gaaaggaagu caucauugcc aaggaugaag ucgcucacac agucaccgag      600

agccgggucc uccagaacac caggcacccg uuccucacug cgcugaagua ugccuuccag      660

acccacgacc gccugugcuu ugugauggag uaugccaacg ggggugagcu guucuuccac      720

cugucccggg agcgugucuu cacagaggag cgggcccggu uuuauggugc agagauuguc      780

ucggcucuug aguacuugca cucgcgggac gugguauacc gcgacaucaa gcuggaaaac      840

cucaugcugg acaaagaugg ccacaucaag aucacugacu uuggccucug caaagagggc      900

aucagugacg gggccaccau gaaaaccuuc ugugggaccc cggaguaccu ggcgccugag      960

gugcuggagg acaaugacua uggccgggcc guggacuggu gggggcuggg uguggucaug     1020

uacgagauga ugugcggccg ccugcccuuc uacaaccagg accacgagcg ccucuucgag     1080

cucauccuca uggaagagau ccgcuucccg cgcacgcuca gccccgaggc caagucccug     1140

cuugcugggc ugcuuaagaa ggaccccaag cagaggcuug guggggggcc cagcgaugcc     1200

aaggagguca uggagcacag guucuuccuc agcaucaacu ggcaggacgu gguccagaag     1260

aagcuccugc cacccuucaa accucagguc acguccgagg ucgacacaag guacuucgau     1320

gaugaauuua ccgcccaguc caucacaauc acacccccug accgcuauga cagccugggc     1380

uuacuggagc uggaccagcg gacccacuuc ccccaguucu ccuacucggc cagcauccgc     1440

gaguga                                                                1446


<210>  7753
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Akt__Homo_sapiens__AAA58364

<400>  7753
augaacgagg ugagcgucau caaggagggc uggcugcaca agcgcgggga guacaucaag       60

accuggcggc cccgcuacuu ccuccugaag uccgacggca gcuucaucgg guacaaggag      120

cggcccgagg cccccgacca gacccugccg ccccucaaca acuucuccgu ggccgagugc      180

cagcugauga agacggagcg cccccggccc aacaccuucg ugauccgcug ccugcagugg      240

accaccguca ucgagcggac guuccacgug gacagccccg acgagcgcga ggaguggaug      300

cgggcgaucc agaugguggc caacucccuc aagcagcgcg cccccggcga ggacccgaug      360

gacuacaagu gcgggagccc cuccgacagc uccaccaccg aggagaugga ggucgccgug      420

agcaaggccc gggcgaaggu gaccaugaac gacuucgacu accugaagcu gcucggcaag      480

ggcacguucg ggaaggucau ccuggugcgc gagaaggcca ccggccggua cuacgccaug      540

aagauccugc gcaaggaggu gaucaucgcc aaggacgagg ucgcgcacac cgugaccgag      600

ucccgggugc uccagaacac gcgccacccc uuccugaccg cccugaagua cgccuuccag      660

acccacgacc ggcucugcuu cgucauggag uacgccaacg ggggcgagcu guucuuccac      720

cugagccgcg agcggguguu caccgaggag cgcgcccggu ucuacggggc ggagaucgug      780

uccgcccucg aguaccugca cagccgcgac gucguguacc gcgacaucaa gcuggagaac      840

cucaugcugg acaaggacgg ccacaucaag aucacggacu ucggccugug caaggagggg      900

aucuccgacg gcgccaccau gaagaccuuc ugcgggaccc ccgaguaccu cgccccggag      960

gugcuggagg acaacgacua cggccgggcc gucgacuggu ggggccuggg gguggugaug     1020

uacgagauga ugugcggccg ccuccccuuc uacaaccagg accacgagcg gcuguucgag     1080

cugauccuca uggaggagau ccgcuucccc cggacgcuga gccccgaggc gaagucccug     1140

cucgccgggc ugcugaagaa ggacccgaag cagcgccucg gcgggggccc cagcgacgcc     1200

aaggagguca uggagcaccg guucuuccug uccaucaacu ggcaggacgu gguccagaag     1260

aagcugcucc cgcccuucaa gccccaggug accagcgagg uggacacccg cuacuucgac     1320

gacgaguuca ccgcccagag caucacgauc accccgcccg accgguacga cucccugggc     1380

cugcucgagc uggaccagcg cacccacuuc ccccaguuca gcuacuccgc cagcauccgg     1440

gaguga                                                                1446


<210>  7754
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Akt__Homo_sapiens__AAA58364

<400>  7754
augaacgagg ucuccgucau caaggagggc uggcuccaca agcgcggcga guacaucaag       60

accuggcgcc cccgcuacuu ccuccucaag uccgacggcu ccuucaucgg cuacaaggag      120

cgccccgagg cccccgacca gacccucccc ccccucaaca acuucuccgu cgccgagugc      180

cagcucauga agaccgagcg cccccgcccc aacaccuucg ucauccgcug ccuccagugg      240

accaccguca ucgagcgcac cuuccacguc gacucccccg acgagcgcga ggaguggaug      300

cgcgccaucc agauggucgc caacucccuc aagcagcgcg cccccggcga ggaccccaug      360

gacuacaagu gcggcucccc cuccgacucc uccaccaccg aggagaugga ggucgccguc      420

uccaaggccc gcgccaaggu caccaugaac gacuucgacu accucaagcu ccucggcaag      480

ggcaccuucg gcaaggucau ccucguccgc gagaaggcca ccggccgcua cuacgccaug      540

aagauccucc gcaaggaggu caucaucgcc aaggacgagg ucgcccacac cgucaccgag      600

ucccgcgucc uccagaacac ccgccacccc uuccucaccg cccucaagua cgccuuccag      660

acccacgacc gccucugcuu cgucauggag uacgccaacg gcggcgagcu cuucuuccac      720

cucucccgcg agcgcgucuu caccgaggag cgcgcccgcu ucuacggcgc cgagaucguc      780

uccgcccucg aguaccucca cucccgcgac gucgucuacc gcgacaucaa gcucgagaac      840

cucaugcucg acaaggacgg ccacaucaag aucaccgacu ucggccucug caaggagggc      900

aucuccgacg gcgccaccau gaagaccuuc ugcggcaccc ccgaguaccu cgcccccgag      960

guccucgagg acaacgacua cggccgcgcc gucgacuggu ggggccucgg cgucgucaug     1020

uacgagauga ugugcggccg ccuccccuuc uacaaccagg accacgagcg ccucuucgag     1080

cucauccuca uggaggagau ccgcuucccc cgcacccucu cccccgaggc caagucccuc     1140

cucgccggcc uccucaagaa ggaccccaag cagcgccucg gcggcggccc cuccgacgcc     1200

aaggagguca uggagcaccg cuucuuccuc uccaucaacu ggcaggacgu cguccagaag     1260

aagcuccucc cccccuucaa gccccagguc accuccgagg ucgacacccg cuacuucgac     1320

gacgaguuca ccgcccaguc caucaccauc accccccccg accgcuacga cucccucggc     1380

cuccucgagc ucgaccagcg cacccacuuc ccccaguucu ccuacuccgc cuccauccgc     1440

gaguga                                                                1446


<210>  7755
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Akt__Homo_sapiens__AAA58364

<400>  7755
augaacgagg ugagcgucau caaggaaggc uggcugcaca aaagagggga guacauuaag       60

accuggaggc cccgguauuu ccuccuuaaa uccgacggau cuuuuauagg uuacaaggaa      120

cgcccugagg ccccagauca gacacugccg cccuugaaua acuucucagu ugcugaaugc      180

caauuaauga aaacugagcg accucgucca aauacguuug ugaucagaug ucugcagugg      240

accacaguaa uugagaggac uuuccaugug gacagucccg augaacggga ggaauggaug      300

cgcgcaaucc agauggucgc caacagccua aagcagagag cgccuggcga ggacccaaug      360

gauuauaagu gcgggucccc cucugacucg ucaaccacag aggaaaugga gguggcuguu      420

agcaaagcca gggcaaaggu gaccaugaau gauuuugacu accucaaacu gcuuggaaag      480

ggcacuuucg guaaagucau ucuggugcgg gaaaaggcca cagggcgcua uuacgcuaug      540

aagaucuugc gaaaagaggu aauaaucgca aaggaugaag uugcccacac cgugacggag      600

aguagagucc uccaaaacac uaggcauccu uuucugaccg cucugaaaua ugccuuccag      660

acacacgacc ggcucuguuu ugugauggag uacgcgaaug gaggcgaauu auucuuucau      720

cugucccgug agcgcguguu cacugaagag agagcaaggu uuuacggcgc cgaaauuguc      780

ucugcucuug aguauuugca cagccgggau guuguguacc gagacaucaa gcuggagaac      840

cuaaugcucg auaaagacgg gcacauuaag aucaccgacu ucggacugug caaagaaggu      900

auauccgaug gcgccacaau gaagaccuuc ugugggacgc cagaguaucu ugcaccggaa      960

guacuggagg acaaugauua cggacgcgcu guggacuggu ggggcuuggg ugucgugaug     1020

uaugaaauga ugugcgggag acuccccuuu uacaaccagg aucaugagag gcuguucgag     1080

uuaauucuga uggaagagau ccgguuuccu cgcacucucu caccagaagc caagagucuu     1140

cuggcgggau ugcugaaaaa ggaccccaaa cagagacuag gcggcgggcc uagcgaugcc     1200

aaggagguua uggagcacag guucuuucuc ucuauuaauu ggcaagacgu gguccagaaa     1260

aagcugcuuc cacccuucaa gccucaggug acauccgaag uagauacccg uuauuuugac     1320

gaugaguuca cugcacaguc aaucacaauc accccgcccg accgguacga cagccuggga     1380

uugcucgaac uggaucaacg aacgcauuuu ccacaguuca guuacucugc uuccauuaga     1440

gaguga                                                                1446


<210>  7756
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Akt__Homo_sapiens__AAA58364

<400>  7756
augaacgagg ugagcgugau caaggagggc uggcugcaca agagaggcga guacaucaag       60

accuggagac ccagauacuu ccugcugaag agcgacggca gcuucaucgg cuacaaggag      120

agacccgagg cccccgacca gacccugccc ccccugaaca acuucagcgu ggccgagugc      180

cagcugauga agaccgagag acccagaccc aacaccuucg ugaucagaug ccugcagugg      240

accaccguga ucgagagaac cuuccacgug gacagccccg acgagagaga ggaguggaug      300

agagccaucc agaugguggc caacagccug aagcagagag cccccggcga ggaccccaug      360

gacuacaagu gcggcagccc cagcgacagc agcaccaccg aggagaugga gguggccgug      420

agcaaggcca gagccaaggu gaccaugaac gacuucgacu accugaagcu gcugggcaag      480

ggcaccuucg gcaaggugau ccuggugaga gagaaggcca ccggcagaua cuacgccaug      540

aagauccuga gaaaggaggu gaucaucgcc aaggacgagg uggcccacac cgugaccgag      600

agcagagugc ugcagaacac cagacacccc uuccugaccg cccugaagua cgccuuccag      660

acccacgaca gacugugcuu cgugauggag uacgccaacg gcggcgagcu guucuuccac      720

cugagcagag agagaguguu caccgaggag agagccagau ucuacggcgc cgagaucgug      780

agcgcccugg aguaccugca cagcagagac gugguguaca gagacaucaa gcuggagaac      840

cugaugcugg acaaggacgg ccacaucaag aucaccgacu ucggccugug caaggagggc      900

aucagcgacg gcgccaccau gaagaccuuc ugcggcaccc ccgaguaccu ggcccccgag      960

gugcuggagg acaacgacua cggcagagcc guggacuggu ggggccuggg cguggugaug     1020

uacgagauga ugugcggcag acugcccuuc uacaaccagg accacgagag acuguucgag     1080

cugauccuga uggaggagau cagauucccc agaacccuga gccccgaggc caagagccug     1140

cuggccggcc ugcugaagaa ggaccccaag cagagacugg gcggcggccc cagcgacgcc     1200

aaggagguga uggagcacag auucuuccug agcaucaacu ggcaggacgu ggugcagaag     1260

aagcugcugc cccccuucaa gccccaggug accagcgagg uggacaccag auacuucgac     1320

gacgaguuca ccgcccagag caucaccauc accccccccg acagauacga cagccugggc     1380

cugcuggagc uggaccagag aacccacuuc ccccaguuca gcuacagcgc cagcaucaga     1440

gaguga                                                                1446


<210>  7757
<211>  1446
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Akt__Homo_sapiens__AAA58364

<400>  7757
augaacgagg ugagcgucau caaggaaggc uggcugcaca aaagagggga guacauuaag       60

accuggcggc cccgcuauuu ccuccugaaa uccgacggau cuuuuaucgg cuacaaggaa      120

agaccugagg ccccggauca gacacuuccc ccucugaaua acuucagcgu ugcugaaugc      180

caacucauga aaacggagcg gccccgcccu aauaccuuug ugauuagaug ucugcagugg      240

acaaccguga ucgagcggac auuccauguc gacucccccg augaacgcga ggaauggaug      300

agagccauuc agaugguggc gaacucucuu aagcagcggg cuccugggga ggacccgaug      360

gauuauaagu gcggaagccc cuccgacucu agcaccacag aggaaaugga gguugccgug      420

uccaaagccc gcgcuaaggu caccaugaau gauuuugacu accugaaacu ccugggcaag      480

gggacguucg gaaaagugau ccugguuaga gaaaaggcca ccggccggua uuacgcuaug      540

aagauccucc gcaaagaggu gauuaucgcc aaggaugaag ucgcgcacac agugaccgag      600

agcagagugc ugcaaaacac acggcauccu uuucuuaccg cccugaaaua ugcuuuccag      660

acgcacgacc gccucuguuu ugucauggag uacgccaaug gcggggaacu guucuuucau      720

cuuucuagag agcggguuuu cacagaagag agagcucgcu uuuacggagc cgaaauugug      780

uccgcgcugg aguaucucca cagccgggau guggucuaca gagacaucaa gcuggagaac      840

cugaugcucg auaaagacgg ccacauuaag aucaccgacu ucgggcugug caaagaagga      900

auuucugaug gcgccacaau gaagaccuuc ugugggaccc ccgaguaucu ugcuccugaa      960

gugcuggagg acaaugauua cggacgcgcc guugacuggu ggggccucgg cguggucaug     1020

uaugaaauga ugugcgggcg gcugcccuuu uacaaccagg aucaugagag acuuuucgag     1080

cugauccuca uggaagagau ccgcuuuccg cggacacugu ccccugaagc uaagagccug     1140

cucgccggac ugcuuaaaaa ggaccccaaa cagagacugg gcgggggacc uucugaugcc     1200

aaggagguga uggagcaccg cuucuuucuc uccauuaauu ggcaagacgu ugugcagaaa     1260

aagcugcuuc cucccuucaa gccccagguc acgagcgaag uggauacccg guauuuugac     1320

gaugaguuca cagcucaguc caucaccauu acaccgcccg acagauacga cucucugggc     1380

cuccuggaac uggaucaacg cacccauuuu ccucaguuca gcuacuccgc gagcauccgg     1440

gaguga                                                                1446


<210>  7758
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__Q9Y243

<400>  7758

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  7759
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Akt__Homo_sapiens__AAD24196

<400>  7759
augagcgaug uuaccauugu gaaagaaggu uggguucaga agaggggaga auauauaaaa       60

aacuggaggc caagauacuu ccuuuugaag acagauggcu cauucauagg auauaaagag      120

aaaccucaag auguggauuu accuuauccc cucaacaacu uuucaguggc aaaaugccag      180

uuaaugaaaa cagaacgacc aaagccaaac acauuuauaa ucagaugucu ccaguggacu      240

acuguuauag agagaacauu ucauguagau acuccagagg aaagggaaga auggacagaa      300

gcuauccagg cuguagcaga cagacugcag aggcaagaag aggagagaau gaauuguagu      360

ccaacuucac aaauugauaa uauaggagag gaagagaugg augccucuac aacccaucau      420

aaaagaaaga caaugaauga uuuugacuau uugaaacuac uagguaaagg cacuuuuggg      480

aaaguuauuu ugguucgaga gaaggcaagu ggaaaauacu augcuaugaa gauucugaag      540

aaagaaguca uuauugcaaa ggaugaagug gcacacacuc uaacugaaag cagaguauua      600

aagaacacua gacaucccuu uuuaacaucc uugaaauauu ccuuccagac aaaagaccgu      660

uuguguuuug ugauggaaua uguuaauggg ggcgagcugu uuuuccauuu gucgagagag      720

cggguguucu cugaggaccg cacacguuuc uauggugcag aaauugucuc ugccuuggac      780

uaucuacauu ccggaaagau uguguaccgu gaucucaagu uggagaaucu aaugcuggac      840

aaagauggcc acauaaaaau uacagauuuu ggacuuugca aagaagggau cacagaugca      900

gccaccauga agacauucug uggcacucca gaauaucugg caccagaggu guuagaagau      960

aaugacuaug gccgagcagu agacuggugg ggccuagggg uugucaugua ugaaaugaug     1020

ugugggaggu uaccuuucua caaccaggac caugagaaac uuuuugaauu aauauuaaug     1080

gaagacauua aauuuccucg aacacucucu ucagaugcaa aaucauugcu uucagggcuc     1140

uugauaaagg auccaaauaa acgccuuggu ggaggaccag augaugcaaa agaaauuaug     1200

agacacaguu ucuucucugg aguaaacugg caagauguau augauaaaaa gcuuguaccu     1260

ccuuuuaaac cucaaguaac aucugagaca gauacuagau auuuugauga agaauuuaca     1320

gcucagacua uuacaauaac accaccugaa aaauaugaug aggaugguau ggacugcaug     1380

gacaaugaga ggcggccgca uuucccucaa uuuuccuacu cugcaagugg acgagaauaa     1440


<210>  7760
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Akt__Homo_sapiens__AAD24196

<400>  7760
augagcgacg ugaccaucgu caaggagggc ugggugcaga agcgcgggga guacaucaag       60

aacuggcggc cccgcuacuu ccugcugaag accgacggcu ccuucaucgg guacaaggag      120

aagccgcagg acguggaccu gcccuacccc cugaacaacu ucagcgucgc caagugccag      180

cucaugaaga cggagcggcc caagccgaac accuucauca uccgcugccu gcaguggacc      240

accgugaucg agcggacguu ccacguggac acccccgagg agcgcgagga guggaccgag      300

gccauccagg cggucgccga ccggcugcag cgccaggagg aggagcggau gaacugcucc      360

cccaccagcc agaucgacaa caucggcgag gaggagaugg acgccuccac gacccaccac      420

aagcgcaaga ccaugaacga cuucgacuac cucaagcugc uggggaaggg caccuucggc      480

aaggugaucc ucgugcggga gaaggccagc gggaaguacu acgccaugaa gauccugaag      540

aaggagguca ucaucgcgaa ggacgaggug gcccacacgc ugaccgaguc ccgcgugcuc      600

aagaacaccc ggcaccccuu ccugaccagc cugaaguacu ccuuccagac gaaggaccgc      660

cucugcuucg ucauggagua cgugaacggc ggggagcugu ucuuccaccu gagccgggag      720

cgcguguucu ccgaggaccg gacccgcuuc uacggcgccg agaucgucag cgcccucgac      780

uaccugcacu ccgggaagau cguguaccgg gaccugaagc ucgagaaccu gaugcuggac      840

aaggacggcc acaucaagau caccgacuuc ggccucugca aggaggggau caccgacgcg      900

gccacgauga agaccuucug cggcaccccg gaguaccugg cccccgaggu gcuggaggac      960

aacgacuacg ggcgcgccgu cgacuggugg ggccucggcg uggugaugua cgagaugaug     1020

ugcgggcggc ugcccuucua caaccaggac cacgagaagc uguucgagcu cauccugaug     1080

gaggacauca aguucccccg cacccugagc uccgacgcca agagccuccu guccggccug     1140

cucaucaagg acccgaacaa gcgccucggg ggcgggcccg acgacgcgaa ggagaucaug     1200

cggcacagcu ucuucuccgg cgucaacugg caggacgugu acgacaagaa gcuggugccg     1260

cccuucaagc cccaggucac gagcgagacc gacacccgcu acuucgacga ggaguucacc     1320

gcccagacga ucaccaucac cccgcccgag aaguacgacg aggacggcau ggacugcaug     1380

gacaacgagc ggcgccccca cuucccccag uucagcuacu ccgccagcgg gcgggaguga     1440


<210>  7761
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Akt__Homo_sapiens__AAD24196

<400>  7761
auguccgacg ucaccaucgu caaggagggc uggguccaga agcgcggcga guacaucaag       60

aacuggcgcc cccgcuacuu ccuccucaag accgacggcu ccuucaucgg cuacaaggag      120

aagccccagg acgucgaccu ccccuacccc cucaacaacu ucuccgucgc caagugccag      180

cucaugaaga ccgagcgccc caagcccaac accuucauca uccgcugccu ccaguggacc      240

accgucaucg agcgcaccuu ccacgucgac acccccgagg agcgcgagga guggaccgag      300

gccauccagg ccgucgccga ccgccuccag cgccaggagg aggagcgcau gaacugcucc      360

cccaccuccc agaucgacaa caucggcgag gaggagaugg acgccuccac cacccaccac      420

aagcgcaaga ccaugaacga cuucgacuac cucaagcucc ucggcaaggg caccuucggc      480

aaggucaucc ucguccgcga gaaggccucc ggcaaguacu acgccaugaa gauccucaag      540

aaggagguca ucaucgccaa ggacgagguc gcccacaccc ucaccgaguc ccgcguccuc      600

aagaacaccc gccaccccuu ccucaccucc cucaaguacu ccuuccagac caaggaccgc      660

cucugcuucg ucauggagua cgucaacggc ggcgagcucu ucuuccaccu cucccgcgag      720

cgcgucuucu ccgaggaccg cacccgcuuc uacggcgccg agaucgucuc cgcccucgac      780

uaccuccacu ccggcaagau cgucuaccgc gaccucaagc ucgagaaccu caugcucgac      840

aaggacggcc acaucaagau caccgacuuc ggccucugca aggagggcau caccgacgcc      900

gccaccauga agaccuucug cggcaccccc gaguaccucg cccccgaggu ccucgaggac      960

aacgacuacg gccgcgccgu cgacuggugg ggccucggcg ucgucaugua cgagaugaug     1020

ugcggccgcc uccccuucua caaccaggac cacgagaagc ucuucgagcu cauccucaug     1080

gaggacauca aguucccccg cacccucucc uccgacgcca agucccuccu cuccggccuc     1140

cucaucaagg accccaacaa gcgccucggc ggcggccccg acgacgccaa ggagaucaug     1200

cgccacuccu ucuucuccgg cgucaacugg caggacgucu acgacaagaa gcucgucccc     1260

cccuucaagc cccaggucac cuccgagacc gacacccgcu acuucgacga ggaguucacc     1320

gcccagacca ucaccaucac cccccccgag aaguacgacg aggacggcau ggacugcaug     1380

gacaacgagc gccgccccca cuucccccag uucuccuacu ccgccuccgg ccgcgaguga     1440


<210>  7762
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Akt__Homo_sapiens__AAD24196

<400>  7762
augagcgacg ugaccaucgu caaggagggc uggguucaga aaagagggga auacauuaag       60

aacuggaggc cccgguauuu ccugcucaaa acagauggau ccuuuauagg uuacaaggag      120

aaaccucaag acguggaucu uccauauccg cugaauaacu ucucuguagc caagugccag      180

uugaugaaga cugaacgccc caaaccuaau acguuuauca uucgauguuu acaguggacc      240

acagugaucg agcguacuuu ccacgucgac accccagaag agagagagga auggacagag      300

gcuauucagg caguggccga uaggcugcaa cggcaggaag aggagcgcau gaacugcuca      360

cccaccaguc agaucgacaa uauaggcgaa gaggaaaugg augcgagcac uacacaucac      420

aagagaaaaa ccaugaacga cuuugauuac cuaaagcucc uggggaaagg aacguucggc      480

aagguuaucc uugugaggga gaaggcuucc gguaaauauu acgccaugaa gauucugaaa      540

aaggaaguca ucauugcaaa agacgaggug gcccauacuu ugaccgaguc ucggguacuc      600

aagaauacac gccacccuuu ucugacuucg cugaaauauu cauuccagac caaggaucga      660

cucuguuuug uuauggaaua cgugaacggg ggagaguuau ucuuucaucu gagcagagaa      720

agggucuuca gugaggaccg gacacguuuu uacggcgcug aaaucguguc cgcacuugau      780

uauuugcacu cuggcaagau aguguaccgc gaccugaaac uagagaaucu caugcuggac      840

aaggaugggc acauuaaaau caccgacuuc ggacuuugca aggaggguau uacggaugcc      900

gcuacuauga aaacauucug uggcacccca gaauaucugg cccccgaggu cuuggaagac      960

aacgauuacg ggagagcggu ugacuggugg ggacucggcg ugguaaugua ugagaugaug     1020

ugcgguaggc ugccuuuuua caaucaagau caugaaaagu uauucgagcu gauccucaug     1080

gaggacauca aguuuccacg gacucuuagc uccgaugcaa aaucacuguu gagugggcua     1140

cugauuaagg acccgaacaa acgacucgga ggcggccccg augacgccaa ggaaauaaug     1200

cgccacagcu ucuuuucugg ggugaauugg caggacgucu augauaaaaa gcuggugccu     1260

ccauucaagc cccagguuac auccgagacc gacacgagau acuuugauga agaguucacc     1320

gcucagacaa ucacuauuac cccuccagag aaauacgacg aagauggaau ggacuguaug     1380

gauaacgaga ggcggcccca uuuuccgcaa uucucauaua gcgccagugg ucgcgaauga     1440


<210>  7763
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Akt__Homo_sapiens__AAD24196

<400>  7763
augagcgacg ugaccaucgu gaaggagggc ugggugcaga agagaggcga guacaucaag       60

aacuggagac ccagauacuu ccugcugaag accgacggca gcuucaucgg cuacaaggag      120

aagccccagg acguggaccu gcccuacccc cugaacaacu ucagcguggc caagugccag      180

cugaugaaga ccgagagacc caagcccaac accuucauca ucagaugccu gcaguggacc      240

accgugaucg agagaaccuu ccacguggac acccccgagg agagagagga guggaccgag      300

gccauccagg ccguggccga cagacugcag agacaggagg aggagagaau gaacugcagc      360

cccaccagcc agaucgacaa caucggcgag gaggagaugg acgccagcac cacccaccac      420

aagagaaaga ccaugaacga cuucgacuac cugaagcugc ugggcaaggg caccuucggc      480

aaggugaucc uggugagaga gaaggccagc ggcaaguacu acgccaugaa gauccugaag      540

aaggagguga ucaucgccaa ggacgaggug gcccacaccc ugaccgagag cagagugcug      600

aagaacacca gacaccccuu ccugaccagc cugaaguaca gcuuccagac caaggacaga      660

cugugcuucg ugauggagua cgugaacggc ggcgagcugu ucuuccaccu gagcagagag      720

agaguguuca gcgaggacag aaccagauuc uacggcgccg agaucgugag cgcccuggac      780

uaccugcaca gcggcaagau cguguacaga gaccugaagc uggagaaccu gaugcuggac      840

aaggacggcc acaucaagau caccgacuuc ggccugugca aggagggcau caccgacgcc      900

gccaccauga agaccuucug cggcaccccc gaguaccugg cccccgaggu gcuggaggac      960

aacgacuacg gcagagccgu ggacuggugg ggccugggcg uggugaugua cgagaugaug     1020

ugcggcagac ugcccuucua caaccaggac cacgagaagc uguucgagcu gauccugaug     1080

gaggacauca aguuccccag aacccugagc agcgacgcca agagccugcu gagcggccug     1140

cugaucaagg accccaacaa gagacugggc ggcggccccg acgacgccaa ggagaucaug     1200

agacacagcu ucuucagcgg cgugaacugg caggacgugu acgacaagaa gcuggugccc     1260

cccuucaagc cccaggugac cagcgagacc gacaccagau acuucgacga ggaguucacc     1320

gcccagacca ucaccaucac cccccccgag aaguacgacg aggacggcau ggacugcaug     1380

gacaacgaga gaagacccca cuucccccag uucagcuaca gcgccagcgg cagagaguga     1440


<210>  7764
<211>  1440
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Akt__Homo_sapiens__AAD24196

<400>  7764
augagcgacg ugaccaucgu caaggagggc uggguucaga aaagagggga auacauuaag       60

aacuggcggc cccgcuauuu ccugcucaaa acagauggau ccuuuaucgg cuacaaggag      120

aaaccucaag acguggaucu gccguauccc cuuaauaacu ucucuguggc caagugccag      180

cugaugaaga cggaaagacc uaaacccaau accuuuauua uccggugucu ccaguggaca      240

accgucauug agcgcacauu ccacguggac accccugaag agagagagga auggacagag      300

gcuauccagg ccguugcgga ucggcugcaa cgccaggaag aggagagaau gaacugcagc      360

cccaccuccc agaucgacaa uauuggggaa gaggaaaugg augcuucuac gacccaucac      420

aagcggaaaa caaugaacga cuuugauuac cuuaagcugc ucggaaaagg caccuucggg      480

aaggugaucc ugguccgcga gaaggccagc ggaaaauauu acgccaugaa gauucugaaa      540

aaggaaguga ucauugcuaa agacgagguu gcccauacac ucaccgaguc cagagugcug      600

aagaauacgc ggcacccuuu ucuuacaucu cugaaauaua gcuuccagac caaggaucgc      660

cucuguuuug ucauggaaua cgugaacggc ggcgagcugu ucuuucaucu uuccagagaa      720

cggguguuca gcgaggaccg cacaagauuu uacggggcug aaaucgucuc ugcccuggau      780

uaucuccacu ccggaaagau uguuuaccgg gaccugaaac uggagaaucu caugcuggac      840

aaggauggcc acaucaaaau caccgacuuc gggcuuugca aggagggaau uaccgaugcg      900

gccacaauga aaacguucug uggcaccccg gaauaucugg cucccgaggu gcucgaagac      960

aacgauuacg ggagagccgu ggacuggugg ggacugggcg ucgugaugua ugagaugaug     1020

ugcggccgcc uuccuuuuua caaucaagau caugaaaagc uguucgagcu cauccugaug     1080

gaggacauua aguuuccccg gacacugagc ucugaugcua aaucccuccu gagcgggcuu     1140

cugaucaagg acccuaacaa aagacucgga ggcgggcccg augacgccaa ggaaauuaug     1200

cgccacucuu ucuuuuccgg aguuaauugg caggacgugu augauaaaaa gcuggucccg     1260

ccuuucaagc cccaggugac cagcgagaca gacacccggu acuuugauga agaguucacg     1320

gcgcagacaa ucaccaucac cccucccgag aaauacgacg aagauggcau ggacuguaug     1380

gauaacgaga gacgccccca uuuuccucaa uucuccuauu cugccagcgg gcgggaauga     1440


<210>  7765
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ATF2__Homo_sapiens__P15336

<400>  7765

Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr 
    130                 135                 140                 


Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly 
    210                 215                 220                 


Gln Thr Met Pro Val Ala Ile Pro Ala Ser Ile Thr Ser Ser Asn Val 
225                 230                 235                 240 


His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Thr Met Val Pro 
                245                 250                 255     


Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser 
            260                 265                 270         


Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Thr Gln Gln His Pro Pro 
        275                 280                 285             


Val Thr Asn Gly Asp Thr Val Lys Gly His Gly Ser Gly Leu Val Arg 
    290                 295                 300                 


Thr Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Thr 
305                 310                 315                 320 


Ser Thr Thr Glu Thr Pro Ala Ser Pro Ala His Thr Thr Pro Gln Thr 
                325                 330                 335     


Gln Ser Thr Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp 
            340                 345                 350         


Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg 
        355                 360                 365             


Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala 
    370                 375                 380                 


Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Thr Leu 
385                 390                 395                 400 


Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys 
                405                 410                 415     


Asp Cys Pro Val Thr Ala Met Gln Lys Lys Ser Gly Tyr His Thr Ala 
            420                 425                 430         


Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His 
        435                 440                 445             


Thr Glu Ala Ile Gln His Ser Ser Val Ser Thr Ser Asn Gly Val Ser 
    450                 455                 460                 


Ser Thr Ser Lys Ala Glu Ala Val Ala Thr Ser Val Leu Thr Gln Met 
465                 470                 475                 480 


Ala Asp Gln Ser Thr Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro 
                485                 490                 495     


Ser Ser Gln Ser Gln Pro Ser Gly Ser 
            500                 505 


<210>  7766
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ATF2__Homo_sapiens__CCDS2262.1

<400>  7766
augaaauuca aguuacaugu gaauucugcc aggcaauaca aggaccugug gaauaugagu       60

gaugacaaac ccuuucuaug uacugcgccu ggauguggcc agcguuuuac caacgaggau      120

cauuuggcug uccauaaaca uaaacaugag augacacuga aauuuggucc agcacguaau      180

gacaguguca uuguggcuga ucagacccca acaccaacaa gauucuugaa aaacugugaa      240

gaaguggguu uguuuaauga guuggcgagu ccauuugaga augaauucaa gaaagcuuca      300

gaagaugaca uuaaaaaaau gccucuagau uuauccccuc uugcaacacc uaucauaaga      360

agcaaaauug aggagccuuc uguuguagaa acaacucacc aggauagucc uuuaccucac      420

ccagagucua cuaccaguga ugagaaggaa guaccauugg cacaaacugc acagcccaca      480

ucagcuauug uucguccagc aucauuacag guucccaaug ugcugcuuac aaguucugac      540

ucaaguguaa uuauucagca ggcaguaccu ucaccaaccu caaguacugu aaucacccag      600

gcaccauccu cuaacaggcc aauugucccu guaccaggcc cauuuccucu ucuguuacau      660

cuuccuaaug gacaaaccau gccuguugcu auuccugcau caauuacaag uucuaaugug      720

cauguuccag cugcaguccc acucguucga ccagucacca uggugccuag uguuccagga      780

aucccagguc cuuccucucc ccaaccagua cagucagaag caaaaaugag auuaaaagcu      840

gcuuugaccc agcaacaucc uccaguuacc aauggugaua cugucaaagg ucaugguagc      900

ggauugguua ggacucaguc agaggaaucu cgaccgcagu cauuacaaca gccagccaca      960

uccacuacag aaacuccggc uucuccagcu cacacaacuc cacagaccca aaguacaagu     1020

ggucgucgga gaagagcagc uaacgaagau ccugaugaaa aaaggagaaa guuuuuagag     1080

cgaaauagag cagcagcuuc aagaugccga caaaaaagga aagucugggu ucagucuuua     1140

gagaagaaag cugaagacuu gaguucauua aauggucagc ugcagaguga agucacccug     1200

cugagaaaug aaguggcaca gcugaaacag cuucuucugg cucauaaaga uugcccugua     1260

accgccaugc agaagaaauc uggcuaucau acugcugaua aagaugauag uucagaagac     1320

auuucagugc cgaguagucc acauacagaa gcuauacagc auaguucggu cagcacaucc     1380

aauggaguca guucaaccuc caaggcagaa gcuguagcca cuucaguccu cacccagaug     1440

gcggaccaga guacagagcc ugcucuuuca cagaucguua uggcuccuuc cucccaguca     1500

cagcccucag gaaguuga                                                   1518


<210>  7767
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ATF2__Homo_sapiens__CCDS2262.1

<400>  7767
augaaguuca agcugcacgu gaacagcgcc cgccaguaca aggaccucug gaacaugucc       60

gacgacaagc ccuuccugug caccgccccg ggcugcgggc agcgguucac caacgaggac      120

caccuggcgg uccacaagca caagcacgag augacgcuca aguucggccc cgcccgcaac      180

gacagcguga ucguggccga ccagaccccc acccccaccc gguuccugaa gaacugcgag      240

gaggucgggc uguucaacga gcucgccucc ccguucgaga acgaguucaa gaaggccagc      300

gaggacgaca ucaagaagau gccccuggac cugagccccc ucgcgacgcc caucauccgc      360

agcaagaucg aggagccguc cgugguggag accacccacc aggacagccc ccugccccac      420

cccgagucca ccacgagcga cgagaaggag gucccgcugg cccagaccgc ccagcccacc      480

uccgccaucg ugcggcccgc gagccuccag gugcccaacg uccugcugac cuccagcgac      540

uccagcguga ucauccagca ggccgugccg ucccccacga gcuccaccgu caucacccag      600

gcccccagca gcaaccgccc caucgugccg gugcccggcc ccuucccccu ccugcugcac      660

cucccgaacg ggcagaccau gcccgucgcc auccccgccu ccaucacgag cuccaacgug      720

cacgugcccg cggccguccc gcuggugcgg cccgugacca ugguccccag cgugccgggc      780

auccccggcc ccuccagccc ccagccggug caguccgagg ccaagaugcg ccugaaggcc      840

gcccucaccc agcagcaccc gcccgucacc aacggggaca cggugaaggg ccacgggagc      900

ggccuggucc ggacccaguc cgaggagagc cgcccccagu cccugcagca gcccgcgacc      960

agcaccacgg agacccccgc cucccccgcc cacaccacgc cccagaccca gagcaccucc     1020

gggcggcgcc ggcgcgccgc caacgaggac ccggacgaga agcggcgcaa guuccucgag     1080

cggaaccgcg cggccgccag ccggugccgc cagaagcgga aggugugggu gcagucccug     1140

gagaagaagg ccgaggaccu gagcucccuc aacggccagc ugcagagcga ggucacccug     1200

cuccgcaacg agguggccca gcugaagcag cugcuccugg cgcacaagga cugccccgug     1260

accgccaugc agaagaaguc cggcuaccac acggccgaca aggacgacuc cagcgaggac     1320

aucuccgucc ccagcagccc ccacaccgag gccauccagc acuccuccgu gagcaccucc     1380

aacgggguga gcuccaccag caaggcggag gccgucgcca cguccgugcu gacccagaug     1440

gccgaccaga gcaccgagcc ggcccucucc cagaucguga uggcgcccag cucccagagc     1500

cagcccagcg gcuccuga                                                   1518


<210>  7768
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ATF2__Homo_sapiens__CCDS2262.1

<400>  7768
augaaguuca agcuccacgu caacuccgcc cgccaguaca aggaccucug gaacaugucc       60

gacgacaagc ccuuccucug caccgccccc ggcugcggcc agcgcuucac caacgaggac      120

caccucgccg uccacaagca caagcacgag augacccuca aguucggccc cgcccgcaac      180

gacuccguca ucgucgccga ccagaccccc acccccaccc gcuuccucaa gaacugcgag      240

gaggucggcc ucuucaacga gcucgccucc cccuucgaga acgaguucaa gaaggccucc      300

gaggacgaca ucaagaagau gccccucgac cucucccccc ucgccacccc caucauccgc      360

uccaagaucg aggagcccuc cgucgucgag accacccacc aggacucccc ccucccccac      420

cccgagucca ccaccuccga cgagaaggag gucccccucg cccagaccgc ccagcccacc      480

uccgccaucg uccgccccgc cucccuccag guccccaacg uccuccucac cuccuccgac      540

uccuccguca ucauccagca ggccgucccc ucccccaccu ccuccaccgu caucacccag      600

gcccccuccu ccaaccgccc caucgucccc guccccggcc ccuucccccu ccuccuccac      660

cuccccaacg gccagaccau gcccgucgcc auccccgccu ccaucaccuc cuccaacguc      720

cacguccccg ccgccguccc ccucguccgc cccgucacca ugguccccuc cguccccggc      780

auccccggcc ccuccucccc ccagcccguc caguccgagg ccaagaugcg ccucaaggcc      840

gcccucaccc agcagcaccc ccccgucacc aacggcgaca ccgucaaggg ccacggcucc      900

ggccucgucc gcacccaguc cgaggagucc cgcccccagu cccuccagca gcccgccacc      960

uccaccaccg agacccccgc cucccccgcc cacaccaccc cccagaccca guccaccucc     1020

ggccgccgcc gccgcgccgc caacgaggac cccgacgaga agcgccgcaa guuccucgag     1080

cgcaaccgcg ccgccgccuc ccgcugccgc cagaagcgca aggucugggu ccagucccuc     1140

gagaagaagg ccgaggaccu cuccucccuc aacggccagc uccaguccga ggucacccuc     1200

cuccgcaacg aggucgccca gcucaagcag cuccuccucg cccacaagga cugccccguc     1260

accgccaugc agaagaaguc cggcuaccac accgccgaca aggacgacuc cuccgaggac     1320

aucuccgucc ccuccucccc ccacaccgag gccauccagc acuccuccgu cuccaccucc     1380

aacggcgucu ccuccaccuc caaggccgag gccgucgcca ccuccguccu cacccagaug     1440

gccgaccagu ccaccgagcc cgcccucucc cagaucguca uggcccccuc cucccagucc     1500

cagcccuccg gcuccuga                                                   1518


<210>  7769
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ATF2__Homo_sapiens__CCDS2262.1

<400>  7769
augaaguuca aacugcacgu gaacagcgcc agacaguaca aggaccucug gaauaugucc       60

gaugacaaac ccuuucuuug caccgcuccu ggcugugggc aaagguucac aaacgaggau      120

caucuggcag uccacaagca uaaacacgaa augacuuuga aguuuggacc agcccggaau      180

gacucuguua ucguggcgga ucagacgccg acccccacac gcuucuuaaa gaacugcgag      240

gaaguagguc uguuuaauga gcuagcuuca ccuuucgaaa acgaguuuaa aaaggccagu      300

gaggacgaua uuaaaaagau gccacucgac cugagccccc uugcaacucc uauaauccga      360

uccaaaauug aggaaccauc uguggucgaa accacacauc aggauucgcc ccugccucac      420

ccagagucaa ccacuagcga cgagaaggaa gugccguugg cccagacagc ucaacccacc      480

agugcaaucg uucguccugc cucccuccag gugccaaaug uccugcugac gucuagcgau      540

uccucaguga uuauccagca ggcuguaccc aguccuacua gcucuaccgu uauaacacaa      600

gccccauccu caaacagacc caucgugccg gucccuggcc ccuucccacu cuuacugcac      660

cuuccuaaug ggcagacuau gcccguggcg auuccagcaa gcaucaccag uucuaacgug      720

cauguccccg ccgcuguucc uuuggugagg ccaguaacaa uggugccguc cguccccggc      780

auuccuggac caagcucgcc ccagccugug cagucugagg ccaagaugcg gcugaaagca      840

gcucuaaccc aacagcaccc acccguuacg aauggugaca cugugaaggg gcauggaucc      900

ggccucgucc gcacacaguc agaagagagu agaccgcaaa gccugcagca gccugccacc      960

uccacuacag aaaccccagc gucucccgcc cacacgaccc cucagacaca aagcacuuca     1020

ggcaggcggc gccgagcagc uaacgaggau cccgacgaga aaagaaggaa guuucuugaa     1080

cggaaucgug ccgcugccag ucgcuguaga cagaaaagga aggugugggu acagucccug     1140

gagaaaaagg cagaagacuu gagcucucuc aacgggcagc ugcaaucaga gguuaccuua     1200

cugcggaaug aaguggccca gcucaagcag cuucuguugg cucacaaaga uugcccaguc     1260

acagcgaugc agaagaaaag uggauaucau acugcagaca aggaugacag cuccgaggau     1320

aucucugugc cuucgagccc ccacaccgag gccauacaac auuccucagu caguacaucu     1380

aacgguguga gcuccaccuc aaaagcugaa gccguugcaa cuagcgugcu aacgcagaug     1440

gccgaccagu cuacagagcc agcucugucc cagauuguaa uggccccgag uagccaaucu     1500

cagccuuccg gcucauga                                                   1518


<210>  7770
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ATF2__Homo_sapiens__CCDS2262.1

<400>  7770
augaaguuca agcugcacgu gaacagcgcc agacaguaca aggaccugug gaacaugagc       60

gacgacaagc ccuuccugug caccgccccc ggcugcggcc agagauucac caacgaggac      120

caccuggccg ugcacaagca caagcacgag augacccuga aguucggccc cgccagaaac      180

gacagcguga ucguggccga ccagaccccc acccccacca gauuccugaa gaacugcgag      240

gaggugggcc uguucaacga gcuggccagc cccuucgaga acgaguucaa gaaggccagc      300

gaggacgaca ucaagaagau gccccuggac cugagccccc uggccacccc caucaucaga      360

agcaagaucg aggagcccag cgugguggag accacccacc aggacagccc ccugccccac      420

cccgagagca ccaccagcga cgagaaggag gugccccugg cccagaccgc ccagcccacc      480

agcgccaucg ugagacccgc cagccugcag gugcccaacg ugcugcugac cagcagcgac      540

agcagcguga ucauccagca ggccgugccc agccccacca gcagcaccgu gaucacccag      600

gcccccagca gcaacagacc caucgugccc gugcccggcc ccuucccccu gcugcugcac      660

cugcccaacg gccagaccau gcccguggcc auccccgcca gcaucaccag cagcaacgug      720

cacgugcccg ccgccgugcc ccuggugaga cccgugacca uggugcccag cgugcccggc      780

auccccggcc ccagcagccc ccagcccgug cagagcgagg ccaagaugag acugaaggcc      840

gcccugaccc agcagcaccc ccccgugacc aacggcgaca ccgugaaggg ccacggcagc      900

ggccugguga gaacccagag cgaggagagc agaccccaga gccugcagca gcccgccacc      960

agcaccaccg agacccccgc cagccccgcc cacaccaccc cccagaccca gagcaccagc     1020

ggcagaagaa gaagagccgc caacgaggac cccgacgaga agagaagaaa guuccuggag     1080

agaaacagag ccgccgccag cagaugcaga cagaagagaa aggugugggu gcagagccug     1140

gagaagaagg ccgaggaccu gagcagccug aacggccagc ugcagagcga ggugacccug     1200

cugagaaacg agguggccca gcugaagcag cugcugcugg cccacaagga cugccccgug     1260

accgccaugc agaagaagag cggcuaccac accgccgaca aggacgacag cagcgaggac     1320

aucagcgugc ccagcagccc ccacaccgag gccauccagc acagcagcgu gagcaccagc     1380

aacggcguga gcagcaccag caaggccgag gccguggcca ccagcgugcu gacccagaug     1440

gccgaccaga gcaccgagcc cgcccugagc cagaucguga uggcccccag cagccagagc     1500

cagcccagcg gcagcuga                                                   1518


<210>  7771
<211>  1518
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ATF2__Homo_sapiens__CCDS2262.1

<400>  7771
augaaguuca aacugcacgu gaacagcgcc agacaguaca aggaccucug gaauaugucc       60

gaugacaaac ccuuucugug caccgcuccu ggcugugggc aacgguucac aaacgaggau      120

caucuugccg uccacaagca uaaacacgaa augacgcuga aguuuggacc ggcgcgcaau      180

gacucuguua ucguggcuga ucagaccccc acaccuacca gauuccucaa gaacugcgag      240

gaagugggcc uguuuaauga gcuugccagc cccuucgaaa acgaguuuaa aaaggccucc      300

gaggacgaua uuaaaaagau gccucuggac cucucucccc uggcuacacc uaucauucgg      360

agcaaaaucg aggaaccguc cgucguggaa accacacauc aggauucucc ccugccucac      420

cccgagagca ccacguccga cgagaaggaa guuccucucg cccagaccgc ucaacccaca      480

agcgccauug ugcgcccggc gucucugcag gucccuaaug ugcuucugac cuccagcgau      540

ucuuccguua ucauccagca ggccgugccc agcccuacau cuuccaccgu cauuacgcaa      600

gcucccagcu ccaacagacc caucgugccu gugccggggc ccuucccucu ccugcuucau      660

cugcccaaug gacagacaau gccugucgcc auucccgcuu cuaucaccag cuccaacguu      720

cacgugccgg ccgcggugcc ucucguccgg cccgugacaa ugguuccuag cgugcccggc      780

auuccugggc ccucuucccc gcagccuguc cagagcgagg ccaagaugcg ccugaaagcu      840

gcccugaccc aacagcaccc ucccgugacc aauggagaca caguuaaggg ccauggcucu      900

gggcucguga gaacgcagag cgaagagucc cggccccaau cucugcagca gccggcuacc      960

agcacaaccg aaacacccgc cuccccugcc cacaccacgc cccagacaca aagcaccucu     1020

ggacgcagac ggcgcgcugc gaacgaggau ccugacgaga aaagacggaa guuucuugaa     1080

cgcaauagag ccgcugccuc ccgguguaga cagaaacgca aggucugggu gcagagccug     1140

gagaaaaagg ccgaagaccu cucuucccug aacggccagc uucaaagcga ggucacccug     1200

cuccggaaug aaguggcuca gcugaagcag cugcuccugg cccacaaaga uugccccguu     1260

acagcgaugc agaagaaauc cggguaucau accgcugaca aggaugacuc uagcgaggau     1320

aucuccgugc cuucuagccc ccacacagag gccauucaac auuccagcgu cucuacgucc     1380

aacggaguga gcucuaccuc caaagccgaa gcuguugcca caagcgugcu uacccagaug     1440

gcugaccagu cuacagagcc ggcccugagc cagaucguca uggcgccuuc cagccaaucu     1500

cagcccuccg gcagcuga                                                   1518


<210>  7772
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  C1QBP__Homo_sapiens__Q07021

<400>  7772

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
1               5                   10                  15      


Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
            20                  25                  30          


Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val 
        35                  40                  45              


Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
    50                  55                  60                  


Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys 
65                  70                  75                  80  


Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile 
                85                  90                  95      


Gln Lys His Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu 
            100                 105                 110         


Leu Asn Gly Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys 
        115                 120                 125             


Ile Thr Val Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp 
    130                 135                 140                 


Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro 
145                 150                 155                 160 


Glu Leu Thr Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp 
                165                 170                 175     


Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu 
            180                 185                 190         


Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu 
        195                 200                 205             


Val Ser Phe Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr 
    210                 215                 220                 


Thr Leu Asn Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met 
225                 230                 235                 240 


Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu 
                245                 250                 255     


Val Glu Leu Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu 
            260                 265                 270         


Glu Asp Leu Lys Ser Phe Val Lys Ser Gln 
        275                 280         


<210>  7773
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  C1QBP__Homo_sapiens__AAA16315

<400>  7773
augcugccuc ugcugcgcug cgugccccgu gugcugggcu ccuccgucgc cggccuccgc       60

gcugccgcgc ccgccucgcc uuuccggcag cuccugcagc cggcaccccg gcugugcacc      120

cggcccuucg ggcugcucag cgugcgcgca gguuccgagc ggcggccggg ccuccugcgg      180

ccucgcggac ccugcgccug uggcuguggc ugcggcucgc ugcacaccga cggagacaaa      240

gcuuuuguug auuuccugag ugaugaaauu aaggaggaaa gaaaaauuca gaagcauaaa      300

acccucccua agaugucugg agguugggag cuggaacuga augggacaga agcgaaauua      360

gugcggaaag uugccgggga aaaaaucacg gucacuuuca acauuaacaa cagcauccca      420

ccaacauuug auggugagga ggaacccucg caagggcaga agguugaaga acaggagccu      480

gaacugacau caacucccaa uuucgugguu gaaguuauaa agaaugauga uggcaagaag      540

gcccuugugu uggacuguca uuauccagag gaugagguug gacaagaaga cgaggcugag      600

agugacaucu ucucuaucag ggaaguuagc uuucagucca cuggcgaguc ugaauggaag      660

gauacuaauu auacacucaa cacagauucc uuggacuggg ccuuauauga ccaccuaaug      720

gauuuccuug ccgaccgagg gguggacaac acuuuugcag augagcuggu ggagcucagc      780

acagcccugg agcaccagga guacauuacu uuucuugaag accucaagag uuuugucaag      840

agccaguag                                                              849


<210>  7774
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       C1QBP__Homo_sapiens__AAA16315

<400>  7774
augcugcccc ugcugcgcug cgugccgcgg guccugggca gcuccguggc cgggcuccgc       60

gccgcggccc ccgccagccc cuuccggcag cugcugcagc ccgccccgcg ccucugcacc      120

cggcccuucg gccugcuguc cgugcgcgcc gggagcgagc ggcgccccgg ccuccugcgg      180

ccccgcgggc cgugcgcgug cggcugcggc ugcggguccc ugcacaccga cggcgacaag      240

gccuucgucg acuuccucag cgacgagauc aaggaggagc ggaagaucca gaagcacaag      300

acgcugccca agauguccgg gggcugggag cuggagcuca acgggaccga ggccaagcug      360

gugcgcaagg uggccggcga gaagaucacc gucaccuuca acaucaacaa cagcaucccg      420

cccacguucg acggcgagga ggagcccucc caggggcaga agguggagga gcaggagccc      480

gagcugacca gcacccccaa cuucgugguc gaggugauca agaacgacga cggcaagaag      540

gcgcucgugc uggacugcca cuaccccgag gacgaggucg ggcaggagga cgaggccgag      600

uccgacaucu ucagcauccg ggaggugucc uuccagagca ccggcgaguc cgaguggaag      660

gacacgaacu acacccugaa caccgacagc cucgacuggg cccuguacga ccaccugaug      720

gacuuccucg ccgaccgcgg cguggacaac accuucgccg acgagcuggu cgagcugucc      780

acggcgcucg agcaccagga guacaucacc uuccuggagg accucaagag cuucgugaag      840

ucccaguga                                                              849


<210>  7775
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       C1QBP__Homo_sapiens__AAA16315

<400>  7775
augcuccccc uccuccgcug cgucccccgc guccucggcu ccuccgucgc cggccuccgc       60

gccgccgccc ccgccucccc cuuccgccag cuccuccagc ccgccccccg ccucugcacc      120

cgccccuucg gccuccucuc cguccgcgcc ggcuccgagc gccgccccgg ccuccuccgc      180

ccccgcggcc ccugcgccug cggcugcggc ugcggcuccc uccacaccga cggcgacaag      240

gccuucgucg acuuccucuc cgacgagauc aaggaggagc gcaagaucca gaagcacaag      300

acccucccca agauguccgg cggcugggag cucgagcuca acggcaccga ggccaagcuc      360

guccgcaagg ucgccggcga gaagaucacc gucaccuuca acaucaacaa cuccaucccc      420

cccaccuucg acggcgagga ggagcccucc cagggccaga aggucgagga gcaggagccc      480

gagcucaccu ccacccccaa cuucgucguc gaggucauca agaacgacga cggcaagaag      540

gcccucgucc ucgacugcca cuaccccgag gacgaggucg gccaggagga cgaggccgag      600

uccgacaucu ucuccauccg cgaggucucc uuccagucca ccggcgaguc cgaguggaag      660

gacaccaacu acacccucaa caccgacucc cucgacuggg cccucuacga ccaccucaug      720

gacuuccucg ccgaccgcgg cgucgacaac accuucgccg acgagcucgu cgagcucucc      780

accgcccucg agcaccagga guacaucacc uuccucgagg accucaaguc cuucgucaag      840

ucccaguga                                                              849


<210>  7776
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       C1QBP__Homo_sapiens__AAA16315

<400>  7776
augcugcccc uccuuagaug cgugccuagg guccugggca gcuccguugc cggguugcgg       60

gcugcagccc cagcgucucc guuccgccag uuacugcaac ccgcuccucg acuauguacc      120

cguccauuug gacuccuguc agugagagcc gguagugaga ggcggcccgg ccuucugcgc      180

ccuagagggc caugcgcaug uggaugcggc ugugguagcu ugcacacaga cggggauaag      240

gccuucguag acuuucucuc cgaugaaauc aaagaggaaa ggaagauuca gaaacauaag      300

acucugccca aaaugucugg aggcugggag cuggaacuca acggcacgga ggcuaaguua      360

gugcggaagg ucgcagggga gaaaauaacc gugacauuca auaucaacaa uucgauuccu      420

ccaacuuuug acggagaaga ggaaccguca cagggucaga agguugagga gcaagaaccc      480

gagcugacca gcacaccuaa cuucgugguc gaagugauca aaaaugauga cggcaagaaa      540

gcccuuguau uggauugcca cuacccagag gacgaaguug ggcaggagga ugaggcugaa      600

agugacaucu uuuccauucg cgaggugucu uuccagagca ccggagaauc cgaguggaag      660

gauacuaacu auacacugaa uaccgacuca cuagauuggg cccucuacga ccaucugaug      720

gacuuucuug cggaucgagg cgucgacaac acguucgcag augaacuggu ggaguugagu      780

acugcccucg agcaccagga auauauaacc uuucuggagg acuuaaagag cuucgugaaa      840

ucucaauga                                                              849


<210>  7777
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       C1QBP__Homo_sapiens__AAA16315

<400>  7777
augcugcccc ugcugagaug cgugcccaga gugcugggca gcagcguggc cggccugaga       60

gccgccgccc ccgccagccc cuucagacag cugcugcagc ccgcccccag acugugcacc      120

agacccuucg gccugcugag cgugagagcc ggcagcgaga gaagacccgg ccugcugaga      180

cccagaggcc ccugcgccug cggcugcggc ugcggcagcc ugcacaccga cggcgacaag      240

gccuucgugg acuuccugag cgacgagauc aaggaggaga gaaagaucca gaagcacaag      300

acccugccca agaugagcgg cggcugggag cuggagcuga acggcaccga ggccaagcug      360

gugagaaagg uggccggcga gaagaucacc gugaccuuca acaucaacaa cagcaucccc      420

cccaccuucg acggcgagga ggagcccagc cagggccaga agguggagga gcaggagccc      480

gagcugacca gcacccccaa cuucguggug gaggugauca agaacgacga cggcaagaag      540

gcccuggugc uggacugcca cuaccccgag gacgaggugg gccaggagga cgaggccgag      600

agcgacaucu ucagcaucag agaggugagc uuccagagca ccggcgagag cgaguggaag      660

gacaccaacu acacccugaa caccgacagc cuggacuggg cccuguacga ccaccugaug      720

gacuuccugg ccgacagagg cguggacaac accuucgccg acgagcuggu ggagcugagc      780

accgcccugg agcaccagga guacaucacc uuccuggagg accugaagag cuucgugaag      840

agccaguga                                                              849


<210>  7778
<211>  849
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       C1QBP__Homo_sapiens__AAA16315

<400>  7778
augcugcccc uccugagaug cgugccucgg guccuuggca gcuccguugc cgggcugcgc       60

gcugccgcgc cggcuucucc cuucagacag cuccugcaac cugcuccccg gcuuuguacc      120

cgcccuuuug gacugcucag cgugagagcc ggcuccgagc ggcgccccgg gcugcugaga      180

ccucggggac cgugcgccug uggcugcggg uguggaucuc uccacacaga cggcgauaag      240

gccuucgugg acuuucugag cgaugaaauc aaagaggaac gcaagauuca gaaacauaag      300

acgcuuccca aaauguccgg cgggugggag cuggaacuca acggaaccga ggcuaagcug      360

gucagaaagg uggccggcga gaaaaucaca guuaccuuca auauuaacaa uucuaucccu      420

cccacauuug acggggaaga ggaaccuagc cagggacaga agguggagga gcaagaaccc      480

gagcuuaccu ccacaccgaa cuucgucgug gaaguuauua aaaaugauga cggcaagaaa      540

gcgcuggugc ucgauugcca cuacccugag gacgaagucg ggcaggagga ugaggccgaa      600

agcgacaucu uuucuauccg ggaggugucc uuccagagca ccggagaauc ugaguggaag      660

gauacgaacu auacccugaa uacagacucc cuggauuggg cucucuacga ccaucugaug      720

gacuuucuug ccgaucgcgg cguggacaac accuucgcug augaacuggu cgagcucagc      780

acagcccugg agcaccagga auauauuacc uuucuugagg accugaaguc uuucguuaaa      840

ucccaauga                                                              849


<210>  7779
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  C1QC__Homo_sapiens__P02747

<400>  7779

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  7780
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  C1QC__Homo_sapiens__CCDS227.1

<400>  7780
auggacgugg ggcccagcuc ccugccccac cuugggcuga agcugcugcu gcuccugcug       60

cugcugcccc ucaggggcca agccaacaca ggcugcuacg ggaucccagg gaugcccggc      120

cugcccgggg caccagggaa ggauggguac gacggacugc cggggcccaa gggggagcca      180

ggaaucccag ccauucccgg gauccgagga cccaaagggc agaagggaga acccggcuua      240

cccggccauc cugggaaaaa uggccccaug ggacccccug ggaugccagg ggugcccggc      300

cccaugggca ucccuggaga gccaggugag gagggcagau acaagcagaa auuccaguca      360

guguucacgg ucacucggca gacccaccag cccccugcac ccaacagccu gaucagauuc      420

aacgcggucc ucaccaaccc gcagggagau uaugacacga gcacuggcaa guucaccugc      480

aaaguccccg gccucuacua cuuugucuac cacgcgucgc auacagccaa ccugugcgug      540

cugcuguacc gcagcggcgu caaagugguc accuucugug gccacacguc caaaaccaau      600

caggucaacu cgggcggugu gcugcugagg uugcaggugg gcgaggaggu guggcuggcu      660

gucaaugacu acuacgacau ggugggcauc cagggcucug acagcgucuu cuccggcuuc      720

cugcucuucc ccgacuag                                                    738


<210>  7781
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       C1QC__Homo_sapiens__CCDS227.1

<400>  7781
auggacgugg gccccagcuc ccugccgcac cucgggcuga agcugcuccu gcugcuccug       60

cugcuccccc ugcgcggcca ggccaacacc gggugcuacg gcauccccgg gaugcccggc      120

cugccgggcg cccccgggaa ggacggcuac gacgggcucc ccggccccaa gggggagccg      180

ggcauccccg cgauccccgg cauccggggg cccaagggcc agaaggggga gccgggccug      240

cccggccacc ccgggaagaa cggccccaug gggccgcccg gcaugcccgg gguccccggc      300

ccgaugggca uccccgggga gcccggcgag gaggggcgcu acaagcagaa guuccagagc      360

guguucaccg ugacgcggca gacccaccag cccccggccc ccaacucccu gauccgcuuc      420

aacgccgucc ucaccaaccc ccagggcgac uacgacacca gcacggggaa guucacgugc      480

aaggugcccg gccuguacua cuucguguac cacgccuccc acaccgccaa ccugugcguc      540

cuccuguacc ggagcggcgu gaaggugguc accuucugcg ggcacaccuc caagaccaac      600

caggugaaca gcggcggggu gcugcuccgc cugcaggucg gcgaggaggu guggcuggcg      660

gugaacgacu acuacgacau ggucgggauc cagggcuccg acagcguguu cuccggcuuc      720

cuccuguucc cggacuga                                                    738


<210>  7782
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       C1QC__Homo_sapiens__CCDS227.1

<400>  7782
auggacgucg gccccuccuc ccucccccac cucggccuca agcuccuccu ccuccuccuc       60

cuccuccccc uccgcggcca ggccaacacc ggcugcuacg gcauccccgg caugcccggc      120

cuccccggcg cccccggcaa ggacggcuac gacggccucc ccggccccaa gggcgagccc      180

ggcauccccg ccauccccgg cauccgcggc cccaagggcc agaagggcga gcccggccuc      240

cccggccacc ccggcaagaa cggccccaug ggcccccccg gcaugcccgg cguccccggc      300

cccaugggca uccccggcga gcccggcgag gagggccgcu acaagcagaa guuccagucc      360

gucuucaccg ucacccgcca gacccaccag ccccccgccc ccaacucccu cauccgcuuc      420

aacgccgucc ucaccaaccc ccagggcgac uacgacaccu ccaccggcaa guucaccugc      480

aagguccccg gccucuacua cuucgucuac cacgccuccc acaccgccaa ccucugcguc      540

cuccucuacc gcuccggcgu caaggucguc accuucugcg gccacaccuc caagaccaac      600

caggucaacu ccggcggcgu ccuccuccgc cuccaggucg gcgaggaggu cuggcucgcc      660

gucaacgacu acuacgacau ggucggcauc cagggcuccg acuccgucuu cuccggcuuc      720

cuccucuucc ccgacuga                                                    738


<210>  7783
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       C1QC__Homo_sapiens__CCDS227.1

<400>  7783
auggacgugg gccccagcuc ccugccucac cucgggcuua agcuguuguu acugcuacuc       60

cugcuuccac ugagaggaca ggccaacacc gguugcuacg gcaucccggg gaugcccgga      120

uugccuggcg cuccagguaa agauggguau gacggacucc ccggcccuaa gggcgagcca      180

gggauucccg caauaccugg aaucaggggu ccaaaaggcc aaaaggggga accgggacug      240

cccggccauc cugguaaaaa ugggccaaug ggacccccug gcaugccagg cguccccggg      300

ccgaugggua uuccuggaga gcccggcgaa gaggggcggu acaagcagaa guuccagucu      360

guuuuuacag ugacucgcca gacgcaccaa ccuccagccc ccaacucacu gauccgauuc      420

aaugcgguac ucaccaaccc acagggagau uaugacacaa guacuggcaa auuuaccugu      480

aaggugcccg guuuauacua uuucgucuac caugcuagcc acacagccaa ucugugcgug      540

cuuuuguauc guuccggggu uaaagugguc accuuuugug gccauacuuc uaagacaaac      600

cagguaaauu cgggaggcgu gcugcuaaga cuccagguug gggaagaggu guggcuggca      660

gucaacgauu acuacgacau gguggguauu caaggaucag auagcguguu caguggcuuu      720

cuucuguucc cugacuga                                                    738


<210>  7784
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       C1QC__Homo_sapiens__CCDS227.1

<400>  7784
auggacgugg gccccagcag ccugccccac cugggccuga agcugcugcu gcugcugcug       60

cugcugcccc ugagaggcca ggccaacacc ggcugcuacg gcauccccgg caugcccggc      120

cugcccggcg cccccggcaa ggacggcuac gacggccugc ccggccccaa gggcgagccc      180

ggcauccccg ccauccccgg caucagaggc cccaagggcc agaagggcga gcccggccug      240

cccggccacc ccggcaagaa cggccccaug ggcccccccg gcaugcccgg cgugcccggc      300

cccaugggca uccccggcga gcccggcgag gagggcagau acaagcagaa guuccagagc      360

guguucaccg ugaccagaca gacccaccag ccccccgccc ccaacagccu gaucagauuc      420

aacgccgugc ugaccaaccc ccagggcgac uacgacacca gcaccggcaa guucaccugc      480

aaggugcccg gccuguacua cuucguguac cacgccagcc acaccgccaa ccugugcgug      540

cugcuguaca gaagcggcgu gaagguggug accuucugcg gccacaccag caagaccaac      600

caggugaaca gcggcggcgu gcugcugaga cugcaggugg gcgaggaggu guggcuggcc      660

gugaacgacu acuacgacau ggugggcauc cagggcagcg acagcguguu cagcggcuuc      720

cugcuguucc ccgacuga                                                    738


<210>  7785
<211>  738
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       C1QC__Homo_sapiens__CCDS227.1

<400>  7785
auggacgugg gccccagcuc ccugccucac cucgggcuga aacuucugcu ccugcuucug       60

cuccugccgc ugagaggaca ggccaacacc ggcugcuacg ggauccccgg aaugccuggc      120

cuccccgggg cuccuggaaa ggauggcuau gacggccugc ccgggccuaa gggagagccg      180

ggcauucccg ccaucccugg gauucgggga cccaaaggcc aaaaggggga accuggacuu      240

cccggccauc cgggcaaaaa ugggccuaug ggacccccug gcaugcccgg gguccccgga      300

ccuaugggca ucccggggga gcccggagaa gagggccgcu acaagcagaa guuccagucu      360

guuuuuacag ugacgagaca gacccaccaa ccucccgcgc cuaacagccu gauucgguuc      420

aaugcugugc ucacaaaccc ccagggcgau uaugacaccu ccacagggaa auuuaccugu      480

aaggucccgg gacuguacua uuucguguac caugccucuc acacagccaa ucuuugcguu      540

cugcucuauc gcagcggcgu gaaagucgug accuuuugug ggcauacguc caagaccaac      600

cagguuaauu cuggaggcgu gcugcugaga cuccaggucg gggaagaggu guggcuggcu      660

gugaacgauu acuacgacau ggucggcauc caaggaagcg auuccguuuu cagcggcuuu      720

cuucuguucc cugacuga                                                    738


<210>  7786
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cardif__Homo_sapiens__Q7Z434

<400>  7786

Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210>  7787
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cardif__Homo_sapiens__ABA54890

<400>  7787
augccguuug cugaagacaa gaccuauaag uauaucugcc gcaauuucag caauuuuugc       60

aauguggaug uuguagagau ucugccuuac cugcccugcc ucacagcaag agaccaggau      120

cgacugcggg ccaccugcac acucucaggg aaccgggaca cccucuggca ucucuucaau      180

acccuucagc ggcggcccgg cuggguggag uacuucauug cggcacugag gggcugugag      240

cuaguugauc ucgcggacga aguggccucu gucuaccaga gcuaccagcc ucggaccucg      300

gaccgucccc cagacccacu ggagccaccg ucacuuccug cugagaggcc agggcccccc      360

acaccugcug cggcccacag cauccccuac aacagcugca gagagaagga gccaaguuac      420

cccaugccug uccaggagac ccaggcgcca gaguccccag gagagaauuc agagcaagcc      480

cugcagacgc ucagccccag agccauccca aggaauccag augguggccc ccuggagucc      540

uccucugacc uggcagcccu cagcccucug accuccagcg ggcaucagga gcaggacaca      600

gaacugggca guacccacac agcaggugcg accuccagcc ucacaccauc ccgugggccu      660

gugucuccau cugucuccuu ccagccccug gcccguucca cccccagggc aagccgcuug      720

ccuggaccca cagggucagu uguaucuacu ggcaccuccu ucuccuccuc auccccuggc      780

uuggccucug caggggcugc agaggguaaa cagggugcag agagugacca ggccgagccu      840

aucaucugcu ccaguggggc agaggcaccu gccaacucuc ugcccuccaa agugccuacc      900

accuugaugc cugugaacac aguggcccug aaagugccug ccaacccagc aucugucagc      960

acagugcccu ccaaguugcc aacuagcuca aagcccccug gugcagugcc uucuaaugcg     1020

cucaccaauc cagcaccauc caaauugccc aucaacucaa cccgugcugg cauggugcca     1080

uccaaagugc cuacuagcau ggugcucacc aaggugucug ccagcacagu ccccacugac     1140

gggagcagca gaaaugagga gaccccagca gcuccaacac ccgccggcgc cacuggaggc     1200

agcucagccu ggcuagacag cagcucugag aauaggggcc uugggucgga gcugaguaag     1260

ccuggcgugc uggcauccca gguagacagc ccguucucgg gcugcuucga ggaucuugcc     1320

aucagugcca gcaccuccuu gggcaugggg cccugccaug gcccagagga gaaugaguau     1380

aaguccgagg gcaccuuugg gauccacgug gcugagaacc ccagcaucca gcuccuggag     1440

ggcaacccug ggccaccugc ggacccggau ggcggcccca ggccacaagc cgaccggaag     1500

uuccaggaga gggaggugcc augccacagg cccucaccug gggcucugug gcuccaggug     1560

gcugugacag gggugcuggu agucacacuc cugguggugc uguaccggcg gcgucugcac     1620

uag                                                                   1623


<210>  7788
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cardif__Homo_sapiens__ABA54890

<400>  7788
augcccuucg ccgaggacaa gaccuacaag uacaucugcc gcaacuucag caacuucugc       60

aacguggacg ucguggagau ccugccguac cuccccugcc ugaccgcccg ggaccaggac      120

cgccugcggg cgacgugcac ccucuccggc aaccgcgaca cccuguggca ccuguucaac      180

acccuccagc ggcgccccgg guggguggag uacuucaucg ccgcccugcg gggcugcgag      240

cuggucgacc ucgccgacga gguggccagc guguaccagu ccuaccagcc ccgcacgagc      300

gaccggccgc ccgacccccu ggagcccccg ucccugcccg cggagcgccc cgggcccccg      360

acccccgccg ccgcccacag cauccccuac aacuccugcc gggagaagga gcccagcuac      420

ccgaugcccg uccaggagac ccaggcgccc gagucccccg gcgagaacag cgagcaggcc      480

cuccagaccc uguccccgcg cgccaucccc cggaaccccg acgggggccc ccuggagagc      540

uccagcgacc ucgccgcccu guccccgcug acgagcuccg gccaccagga gcaggacacc      600

gagcucggga gcacccacac cgcgggcgcc acguccagcc ugacccccag ccgcgggccc      660

guguccccca gcguguccuu ccagccgcug gcccggagca cgccccgcgc cucccggcuc      720

cccggcccga ccgggagcgu cguguccacc ggcaccagcu ucuccagcuc cagccccggc      780

cuggccuccg cgggggccgc cgagggcaag cagggggccg agagcgacca ggccgagccc      840

aucaucugcu ccagcggcgc ggaggccccc gccaacuccc ugccgagcaa ggugcccacc      900

acccucaugc ccgucaacac gguggcccug aaggugcccg ccaacccggc guccgucagc      960

accgugccca gcaagcugcc caccuccagc aagcccccgg gcgccgugcc cuccaacgcc     1020

cucaccaacc ccgcccccag caagcugccg aucaacucca cgcgcgcggg gauggucccc     1080

agcaaggugc ccaccuccau ggugcugacc aaggucagcg ccuccaccgu gcccacggac     1140

ggcagcuccc ggaacgagga gaccccggcc gcccccaccc ccgccggggc gaccggcggg     1200

agcuccgccu ggcucgacag cuccagcgag aaccgcggcc ugggcuccga gcugagcaag     1260

cccggggugc ucgccagcca ggucgacucc ccguucagcg gcugcuucga ggaccuggcc     1320

aucuccgcca gcacgucccu ggggaugggc cccugccacg ggcccgagga gaacgaguac     1380

aagagcgagg gcaccuucgg cauccacgug gcggagaacc cguccaucca gcuccuggag     1440

gggaaccccg gcccgcccgc cgaccccgac gggggccccc ggccccaggc cgaccgcaag     1500

uuccaggagc gcgagguccc cugccaccgg ccgagccccg gggcccugug gcuccaggug     1560

gccgugaccg gcguccuggu ggugacccug cucgucgugc uguaccgccg gcgccugcac     1620

uga                                                                   1623


<210>  7789
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cardif__Homo_sapiens__ABA54890

<400>  7789
augcccuucg ccgaggacaa gaccuacaag uacaucugcc gcaacuucuc caacuucugc       60

aacgucgacg ucgucgagau ccuccccuac cuccccugcc ucaccgcccg cgaccaggac      120

cgccuccgcg ccaccugcac ccucuccggc aaccgcgaca cccucuggca ccucuucaac      180

acccuccagc gccgccccgg cugggucgag uacuucaucg ccgcccuccg cggcugcgag      240

cucgucgacc ucgccgacga ggucgccucc gucuaccagu ccuaccagcc ccgcaccucc      300

gaccgccccc ccgacccccu cgagcccccc ucccuccccg ccgagcgccc cggccccccc      360

acccccgccg ccgcccacuc cauccccuac aacuccugcc gcgagaagga gcccuccuac      420

cccaugcccg uccaggagac ccaggccccc gagucccccg gcgagaacuc cgagcaggcc      480

cuccagaccc ucuccccccg cgccaucccc cgcaaccccg acggcggccc ccucgagucc      540

uccuccgacc ucgccgcccu cuccccccuc accuccuccg gccaccagga gcaggacacc      600

gagcucggcu ccacccacac cgccggcgcc accuccuccc ucacccccuc ccgcggcccc      660

gucucccccu ccgucuccuu ccagccccuc gcccgcucca ccccccgcgc cucccgccuc      720

cccggcccca ccggcuccgu cgucuccacc ggcaccuccu ucuccuccuc cucccccggc      780

cucgccuccg ccggcgccgc cgagggcaag cagggcgccg aguccgacca ggccgagccc      840

aucaucugcu ccuccggcgc cgaggccccc gccaacuccc uccccuccaa gguccccacc      900

acccucaugc ccgucaacac cgucgcccuc aagguccccg ccaaccccgc cuccgucucc      960

accguccccu ccaagcuccc caccuccucc aagccccccg gcgccguccc cuccaacgcc     1020

cucaccaacc ccgcccccuc caagcucccc aucaacucca cccgcgccgg cauggucccc     1080

uccaaggucc ccaccuccau gguccucacc aaggucuccg ccuccaccgu ccccaccgac     1140

ggcuccuccc gcaacgagga gacccccgcc gcccccaccc ccgccggcgc caccggcggc     1200

uccuccgccu ggcucgacuc cuccuccgag aaccgcggcc ucggcuccga gcucuccaag     1260

cccggcgucc ucgccuccca ggucgacucc cccuucuccg gcugcuucga ggaccucgcc     1320

aucuccgccu ccaccucccu cggcaugggc cccugccacg gccccgagga gaacgaguac     1380

aaguccgagg gcaccuucgg cauccacguc gccgagaacc ccuccaucca gcuccucgag     1440

ggcaaccccg gcccccccgc cgaccccgac ggcggccccc gcccccaggc cgaccgcaag     1500

uuccaggagc gcgagguccc cugccaccgc cccucccccg gcgcccucug gcuccagguc     1560

gccgucaccg gcguccucgu cgucacccuc cucgucgucc ucuaccgccg ccgccuccac     1620

uga                                                                   1623


<210>  7790
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cardif__Homo_sapiens__ABA54890

<400>  7790
augcccuucg ccgaggacaa gaccuacaaa uauaucugca gaaacuuuag caauuucugu       60

aacguggaug ucguugaaau ucugccuuac cucccaugcc uuacagcuag ggaccaggau      120

cggcugcgcg caacuuguac guuguccggc aaucgagaca ccuuauggca ccuguuuaac      180

acacuacaac guagaccggg guggguggag uauuucauag ccgcgcucag gggaugcgaa      240

cugguagauc uugcugacga gguggccucu gucuaccagu cauaucagcc ccggacuagc      300

gaucgcccuc cagacccccu ggaaccucca aguuugcccg cagagagacc ugguccaccg      360

acccccgccg cugcacauuc caucccuuac aauucuugua gggagaagga accaucguau      420

cccaugccug ugcaggagac acaagcccca gaaucacccg gcgagaacag cgagcaggcu      480

cuccagaccc ugaguccgcg ggccauuccu cgcaaucccg augggggacc acuggaaucc      540

ucuagcgacc ucgcggcauu auccccucug acuucaagug gccaccagga gcaagauaca      600

gaacuuggua gcacccauac ggccggggcu acuucuuccu ugacccccuc acgaggacca      660

guuagcccca gugugucuuu ucagccucug gccagaucca caccaagggc aagccggcua      720

ccgggcccca cuggcucggu cgugucuacc gggacauccu ucucaaguag cuccccugga      780

cucgcuucug ccggugcggc cgagggcaaa cagggggcag aaagcgacca ggcugagcca      840

aucauuugcu caaguggagc cgaggcuccc gccaacuccc ugccuagcaa gguaccaacc      900

acgcuuaugc ccguuaauac uguggcacug aaagucccgg ccaacccugc uucuguguca      960

acagugccaa guaaguugcc caccagcucc aagccucccg gcgcgguccc aucuaaugca     1020

cucacuaacc cugcccccuc gaaacugcca aucaauagca cacgugcugg uaugguuccg     1080

uccaaggugc cuaccucaau gguauuaacg aaagugagug ccucuaccgu ccccacagau     1140

gggagcuccc gcaacgaaga gacuccagca gcccccaccc cugcuggagc cacaggcggc     1200

ucaagcgcau ggcuggacuc uuccagugaa aauagagggc ucggaagcga gcuuucuaag     1260

ccaggugugc uggcguccca aguugacuca cccuuuagug gcuguuucga agauuuggcu     1320

auaagcgccu cgacuucccu agggauggga ccuugccacg gcccggagga gaacgaauac     1380

aaaucugagg guaccuuugg gauccaugug gcagaaaacc caagcauuca gcugcucgag     1440

ggcaaucccg gaccuccagc cgaccccgau ggcgggccua ggccgcaggc ugaccggaag     1500

uuccaagaac gagagguccc cugucaccgc ccaucaccug gagcccugug gcuucaggug     1560

gcaguaacag guguucuggu ggucaccuug cucguggucc uguacagaag gcgguuacac     1620

uga                                                                   1623


<210>  7791
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cardif__Homo_sapiens__ABA54890

<400>  7791
augcccuucg ccgaggacaa gaccuacaag uacaucugca gaaacuucag caacuucugc       60

aacguggacg ugguggagau ccugcccuac cugcccugcc ugaccgccag agaccaggac      120

agacugagag ccaccugcac ccugagcggc aacagagaca cccuguggca ccuguucaac      180

acccugcaga gaagacccgg cuggguggag uacuucaucg ccgcccugag aggcugcgag      240

cugguggacc uggccgacga gguggccagc guguaccaga gcuaccagcc cagaaccagc      300

gacagacccc ccgacccccu ggagcccccc agccugcccg ccgagagacc cggccccccc      360

acccccgccg ccgcccacag cauccccuac aacagcugca gagagaagga gcccagcuac      420

cccaugcccg ugcaggagac ccaggccccc gagagccccg gcgagaacag cgagcaggcc      480

cugcagaccc ugagccccag agccaucccc agaaaccccg acggcggccc ccuggagagc      540

agcagcgacc uggccgcccu gagcccccug accagcagcg gccaccagga gcaggacacc      600

gagcugggca gcacccacac cgccggcgcc accagcagcc ugacccccag cagaggcccc      660

gugagcccca gcgugagcuu ccagccccug gccagaagca cccccagagc cagcagacug      720

cccggcccca ccggcagcgu ggugagcacc ggcaccagcu ucagcagcag cagccccggc      780

cuggccagcg ccggcgccgc cgagggcaag cagggcgccg agagcgacca ggccgagccc      840

aucaucugca gcagcggcgc cgaggccccc gccaacagcc ugcccagcaa ggugcccacc      900

acccugaugc ccgugaacac cguggcccug aaggugcccg ccaaccccgc cagcgugagc      960

accgugccca gcaagcugcc caccagcagc aagccccccg gcgccgugcc cagcaacgcc     1020

cugaccaacc ccgcccccag caagcugccc aucaacagca ccagagccgg cauggugccc     1080

agcaaggugc ccaccagcau ggugcugacc aaggugagcg ccagcaccgu gcccaccgac     1140

ggcagcagca gaaacgagga gacccccgcc gcccccaccc ccgccggcgc caccggcggc     1200

agcagcgccu ggcuggacag cagcagcgag aacagaggcc ugggcagcga gcugagcaag     1260

cccggcgugc uggccagcca gguggacagc cccuucagcg gcugcuucga ggaccuggcc     1320

aucagcgcca gcaccagccu gggcaugggc cccugccacg gccccgagga gaacgaguac     1380

aagagcgagg gcaccuucgg cauccacgug gccgagaacc ccagcaucca gcugcuggag     1440

ggcaaccccg gcccccccgc cgaccccgac ggcggcccca gaccccaggc cgacagaaag     1500

uuccaggaga gagaggugcc cugccacaga cccagccccg gcgcccugug gcugcaggug     1560

gccgugaccg gcgugcuggu ggugacccug cugguggugc uguacagaag aagacugcac     1620

uga                                                                   1623


<210>  7792
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cardif__Homo_sapiens__ABA54890

<400>  7792
augcccuucg ccgaggacaa gaccuacaaa uauaucugca gaaacuuuag caauuucugu       60

aacguggaug ucguugaaau ucugccuuac cucccgugcc ugacagcucg ggaccaggau      120

cgccuuagag ccacguguac ccuguccggc aaucgggaca cacucuggca ccuguuuaac      180

acccuucaac gcagacccgg guggguggag uauuucaucg cggcucugcg gggaugcgaa      240

cucguggauc uggccgacga ggucgccucu guguaccaga gcuaucagcc ucgcacaucc      300

gauagacccc cugacccccu ggaaccuccg ucucuccccg cugagcggcc ugggcccccu      360

acccccgccg cugcccauag cauuccguac aauuccuguc gcgagaagga accuucuuau      420

cccaugccug uucaggagac acaagcgccc gaaagccccg gcgagaacuc cgagcaggcc      480

cugcagaccc uuagcccuag agcuaucccg cggaaucccg auggaggccc ucuggaaucu      540

uccagcgacc ucgccgcucu gucuccccuu acguccagcg ggcaccagga gcaagauacc      600

gaacugggau cuacacauac cgccggcgcg acauccagcc ucaccccuuc ccgcggcccc      660

gugucuccga gcgucuccuu ucagccucug gccagaagca cgccccgggc uucucgccug      720

ccugggccca caggauccgu gguuagcacc ggcacaucuu ucagcuccuc uagcccuggg      780

cucgccuccg cuggagccgc cgagggcaaa cagggggcug aaagcgacca ggcggagccc      840

auuaucuguu cuuccggagc cgaggcuccg gccaacagcc ugccuucuaa ggugcccacc      900

acccuuaugc ccgucaauac aguggcccug aaagugccug cuaacccggc cuccgucagc      960

acgguucccu ccaagcuccc uaccucuagc aagcccccug gcgcggugcc cuccaaugcu     1020

cugacaaacc cugcccccuc uaaacuuccg aucaauagca ccagagccgg cauggugccu     1080

uccaaggucc ccacaagcau ggugcugacc aaaguuucug cuuccacggu gccuacagau     1140

gggagcucuc ggaacgaaga gacccccgcc gcuccgaccc cugccggagc gacaggcggg     1200

uccagcgccu ggcucgacuc uagcuccgaa aauagaggac ugggcagcga gcugucuaag     1260

cccggggucc ucgcuuccca aguggacagc ccuuuuuccg gaugcuucga agaucuggcc     1320

auuucugcua gcaccucccu uggcaugggc cccugccacg ggcccgagga gaacgaauac     1380

aaaucugagg gaacauuugg cauccauguu gccgaaaacc cuagcauuca gcugcucgag     1440

gggaauccgg gacccccugc ggaccccgau ggcgggccuc gcccccaggc cgaccggaag     1500

uuccaagaaa gagaggugcc uugucaccgc ccgucccccg gcgcucugug gcuucagguc     1560

gccgugacgg gaguccuggu gguuacccuc cugguggucc uguaccggag acgccuccac     1620

uga                                                                   1623


<210>  7793
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD59,Beta-Defensin__Homo_sapiens__P13987

<400>  7793

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             






<210>  7794
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7794
augggaaucc aaggaggguc uguccuguuc gggcugcugc ucguccuggc ugucuucugc       60

cauucagguc auagccugca gugcuacaac uguccuaacc caacugcuga cugcaaaaca      120

gccgucaauu guucaucuga uuuugaugcg ugucucauua ccaaagcugg guuacaagug      180

uauaacaagu guuggaaguu ugagcauugc aauuucaacg acgucacaac ccgcuugagg      240

gaaaaugagc uaacguacua cugcugcaag aaggaccugu guaacuuuaa cgaacagcuu      300

gaaaauggug ggacauccuu aucagagaaa acaguucuuc ugcuggugac uccauuucug      360

gcagcagccu ggagccuuca ucccuaa                                          387


<210>  7795
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7795
augggcaucc agggcgggag cgugcuguuc gggcuccugc ugguccucgc cguguucugc       60

cacuccggcc acagccugca gugcuacaac ugccccaacc cgaccgccga cugcaagacc      120

gcggugaacu gcuccagcga cuucgacgcc ugccugauca cgaaggccgg gcuccagguc      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgugaccac ccgccugcgg      240

gagaacgagc ugaccuacua cugcugcaag aaggaccucu gcaacuucaa cgagcagcug      300

gagaacggcg gcacgucccu gagcgagaag accgugcucc ugcuggucac ccccuuccuc      360

gccgccgcgu ggucccugca ccccuga                                          387


<210>  7796
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7796
augggcaucc agggcggcuc cguccucuuc ggccuccucc ucguccucgc cgucuucugc       60

cacuccggcc acucccucca gugcuacaac ugccccaacc ccaccgccga cugcaagacc      120

gccgucaacu gcuccuccga cuucgacgcc ugccucauca ccaaggccgg ccuccagguc      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgucaccac ccgccuccgc      240

gagaacgagc ucaccuacua cugcugcaag aaggaccucu gcaacuucaa cgagcagcuc      300

gagaacggcg gcaccucccu cuccgagaag accguccucc uccucgucac ccccuuccuc      360

gccgccgccu ggucccucca ccccuga                                          387


<210>  7797
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7797
augggcaucc aagggggaag cgugcuguuc ggucuccuuc uggucuuggc cguguuuugc       60

cacuccggcc auucuuuaca guguuacaac ugccccaauc cuaccgcuga cuguaagaca      120

gcaguuaacu gcucaaguga uuucgacgcc ugucugauua cuaaagcggg gcuacaggua      180

uauaauaagu gcuggaaauu ugagcacugu aacuucaaug augugacgac cagacucagg      240

gaaaacgagc ugacauacua uugcuguaag aaagaccuuu gcaauuuuaa cgaacagcug      300

gagaauggag gcacuagcuu guccgaaaag accguccucc ugcuggugac accauuccuc      360

gcugccgcau ggucuuuaca uccguga                                          387


<210>  7798
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7798
augggcaucc agggcggcag cgugcuguuc ggccugcugc uggugcuggc cguguucugc       60

cacagcggcc acagccugca gugcuacaac ugccccaacc ccaccgccga cugcaagacc      120

gccgugaacu gcagcagcga cuucgacgcc ugccugauca ccaaggccgg ccugcaggug      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgugaccac cagacugaga      240

gagaacgagc ugaccuacua cugcugcaag aaggaccugu gcaacuucaa cgagcagcug      300

gagaacggcg gcaccagccu gagcgagaag accgugcugc ugcuggugac ccccuuccug      360

gccgccgccu ggagccugca ccccuga                                          387


<210>  7799
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD59,Beta-Defensin__Homo_sapiens__AAA51952

<400>  7799
augggcaucc aagggggaag cgugcuguuc ggccuccugc uuguccuggc cguguuuugc       60

cacuccgggc auucucucca guguuacaac ugccccaauc cuaccgcuga cuguaagaca      120

gccguuaacu gcagcuccga uuucgacgcg ugucugauua cgaaagcugg acuucaggug      180

uauaauaagu gcuggaaauu ugagcacugu aacuucaaug augucaccac aagacugcgg      240

gaaaacgagc ucaccuacua uugcuguaag aaagaccugu gcaauuuuaa cgaacagcug      300

gagaauggcg ggacaucucu cagcgaaaag accgugcugc uucugguuac accguuccuc      360

gccgccgcuu ggucccugca ucccuga                                          387


<210>  7800
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CD59,Beta-Defensin__Homo_sapiens__Q6FHM9

<400>  7800

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             






<210>  7801
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7801
augggaaucc aaggaggguc uguccuguuc gggcugcugc ucguccuggc ugucuucugc       60

cauucagguc auagccugca gugcuacaac uguccuaacc caacugcuga cugcaaaaca      120

gccgucaauu guucaucuga uuuugaugcg ugucucauua ccaaagcugg guuacaagug      180

uauaacaagu guuggaaguu ugagcauugc aauuucaacg acgucacaac ccgcuugagg      240

gaaaaugagc uaacguacua cugcugcaag aaggaccugu guaacuuuaa cgaacagcuu      300

gaaaauggug ggacauccuu aucagagaaa acaguucuuc ugcuggugac uccauuucug      360

gcagcagccu ggagccuuca ucccuaa                                          387


<210>  7802
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7802
augggcaucc agggcgggag cgugcuguuc gggcuccugc ugguccucgc cguguucugc       60

cacuccggcc acagccugca gugcuacaac ugccccaacc cgaccgccga cugcaagacc      120

gcggugaacu gcuccagcga cuucgacgcc ugccugauca cgaaggccgg gcuccagguc      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgugaccac ccgccugcgg      240

gagaacgagc ugaccuacua cugcugcaag aaggaccucu gcaacuucaa cgagcagcug      300

gagaacggcg gcacgucccu gagcgagaag accgugcucc ugcuggucac ccccuuccuc      360

gccgccgcgu ggucccugca ccccuga                                          387


<210>  7803
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7803
augggcaucc agggcggcuc cguccucuuc ggccuccucc ucguccucgc cgucuucugc       60

cacuccggcc acucccucca gugcuacaac ugccccaacc ccaccgccga cugcaagacc      120

gccgucaacu gcuccuccga cuucgacgcc ugccucauca ccaaggccgg ccuccagguc      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgucaccac ccgccuccgc      240

gagaacgagc ucaccuacua cugcugcaag aaggaccucu gcaacuucaa cgagcagcuc      300

gagaacggcg gcaccucccu cuccgagaag accguccucc uccucgucac ccccuuccuc      360

gccgccgccu ggucccucca ccccuga                                          387


<210>  7804
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7804
augggcaucc aagggggaag cgugcuguuc ggucuccuuc uggucuuggc cguguuuugc       60

cacuccggcc auucuuuaca guguuacaac ugccccaauc cuaccgcuga cuguaagaca      120

gcaguuaacu gcucaaguga uuucgacgcc ugucugauua cuaaagcggg gcuacaggua      180

uauaauaagu gcuggaaauu ugagcacugu aacuucaaug augugacgac cagacucagg      240

gaaaacgagc ugacauacua uugcuguaag aaagaccuuu gcaauuuuaa cgaacagcug      300

gagaauggag gcacuagcuu guccgaaaag accguccucc ugcuggugac accauuccuc      360

gcugccgcau ggucuuuaca uccguga                                          387


<210>  7805
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7805
augggcaucc agggcggcag cgugcuguuc ggccugcugc uggugcuggc cguguucugc       60

cacagcggcc acagccugca gugcuacaac ugccccaacc ccaccgccga cugcaagacc      120

gccgugaacu gcagcagcga cuucgacgcc ugccugauca ccaaggccgg ccugcaggug      180

uacaacaagu gcuggaaguu cgagcacugc aacuucaacg acgugaccac cagacugaga      240

gagaacgagc ugaccuacua cugcugcaag aaggaccugu gcaacuucaa cgagcagcug      300

gagaacggcg gcaccagccu gagcgagaag accgugcugc ugcuggugac ccccuuccug      360

gccgccgccu ggagccugca ccccuga                                          387


<210>  7806
<211>  387
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CD59,Beta-Defensin__Homo_sapiens__BAG34721

<400>  7806
augggcaucc aagggggaag cgugcuguuc ggccuccugc uuguccuggc cguguuuugc       60

cacuccgggc auucucucca guguuacaac ugccccaauc cuaccgcuga cuguaagaca      120

gccguuaacu gcagcuccga uuucgacgcg ugucugauua cgaaagcugg acuucaggug      180

uauaauaagu gcuggaaauu ugagcacugu aacuucaaug augucaccac aagacugcgg      240

gaaaacgagc ucaccuacua uugcuguaag aaagaccugu gcaauuuuaa cgaacagcug      300

gagaauggcg ggacaucucu cagcgaaaag accgugcugc uucugguuac accguuccuc      360

gccgccgcuu ggucccugca ucccuga                                          387


<210>  7807
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__A0A024RAE4

<400>  7807

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  7808
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__EAW95002

<400>  7808
augcagacaa uuaagugugu uguugugggc gauggugcug uugguaaaac augucuccug       60

auauccuaca caacaaacaa auuuccaucg gaauauguac cgacuguuuu ugacaacuau      120

gcagucacag uuaugauugg uggagaacca uauacucuug gacuuuuuga uacugcaggg      180

caagaggauu augacagauu acgaccgcug aguuauccac aaacagaugu auuucuaguc      240

uguuuuucag uggucucucc aucuucauuu gaaaacguga aagaaaagug ggugccugag      300

auaacucacc acuguccaaa gacuccuuuc uugcuuguug ggacucaaau ugaucucaga      360

gaugaccccu cuacuauuga gaaacuugcc aagaacaaac agaagccuau cacuccagag      420

acugcugaaa agcuggcccg ugaccugaag gcugucaagu auguggagug uucugcacuu      480

acacagaaag gccuaaagaa uguauuugac gaagcaauau uggcugcccu ggagccucca      540

gaaccgaaga agagccgcag gugugugcug cuauga                                576


<210>  7809
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cdc42__Homo_sapiens__EAW95002

<400>  7809
augcagacca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca cgaccaacaa guuccccucc gaguacgucc cgaccguguu cgacaacuac      120

gccgugaccg ucaugaucgg gggcgagccc uacacgcugg ggcuguucga caccgcgggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucuccg ucgugagccc guccagcuuc gagaacguga aggagaagug gguccccgag      300

aucacccacc acugccccaa gacgcccuuc cuccuggugg gcacccagau cgaccugcgc      360

gacgacccgu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

acggccgaga agcuggcccg ggaccugaag gccgugaagu acgucgagug cagcgcgcuc      480

acccagaagg ggcugaagaa cguguucgac gaggccaucc uggccgcccu cgagcccccg      540

gagcccaaga agucccgccg gugcgugcug cuguga                                576


<210>  7810
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cdc42__Homo_sapiens__EAW95002

<400>  7810
augcagacca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacaa guuccccucc gaguacgucc ccaccgucuu cgacaacuac      120

gccgucaccg ucaugaucgg cggcgagccc uacacccucg gccucuucga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgacgu cuuccucguc      240

ugcuucuccg ucgucucccc cuccuccuuc gagaacguca aggagaagug gguccccgag      300

aucacccacc acugccccaa gacccccuuc cuccucgucg gcacccagau cgaccuccgc      360

gacgaccccu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcucgcccg cgaccucaag gccgucaagu acgucgagug cuccgcccuc      480

acccagaagg gccucaagaa cgucuucgac gaggccaucc ucgccgcccu cgagcccccc      540

gagcccaaga agucccgccg cugcguccuc cucuga                                576


<210>  7811
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cdc42__Homo_sapiens__EAW95002

<400>  7811
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cuacgaacaa guuccccucc gaguauguac cuaccguguu ugauaauuac      120

gcugucacag ugaugauagg uggcgaacca uauacucuug ggcuguucga caccgcagga      180

caagaggauu acgacagauu gaggccguua ucuuaucccc agacagaugu uuuucuggug      240

ugcuucucag ucgugagucc uagcuccuuu gaaaacguaa aagagaagug gguuccagaa      300

aucacccacc auugucccaa aacuccuuuc cuacucgugg gcacacagau ugaccugcgg      360

gaugacccau cuaccaucga gaaacuugcc aagaauaagc agaagcccau uacgccugag      420

acugcggaaa aacuggcucg cgauuugaag gccgucaaau acguggagug cucggcacuc      480

acccaaaagg gucugaagaa cguguuugac gaagccaucc uggcugcacu cgagccaccg      540

gagcccaaaa agucacgacg uugugucuua cuguga                                576


<210>  7812
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cdc42__Homo_sapiens__EAW95002

<400>  7812
augcagacca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacaa guuccccagc gaguacgugc ccaccguguu cgacaacuac      120

gccgugaccg ugaugaucgg cggcgagccc uacacccugg gccuguucga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucagcg uggugagccc cagcagcuuc gagaacguga aggagaagug ggugcccgag      300

aucacccacc acugccccaa gacccccuuc cugcuggugg gcacccagau cgaccugaga      360

gacgacccca gcaccaucga gaagcuggcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcuggccag agaccugaag gccgugaagu acguggagug cagcgcccug      480

acccagaagg gccugaagaa cguguucgac gaggccaucc uggccgcccu ggagcccccc      540

gagcccaaga agagcagaag augcgugcug cuguga                                576


<210>  7813
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cdc42__Homo_sapiens__EAW95002

<400>  7813
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cgaccaacaa guuccccucc gaguaugugc cuacagucuu ugauaauuac      120

gcugugaccg uuaugaucgg cggggaaccg uauacacugg gacuuuucga caccgccggc      180

caagaggauu acgacagacu gcggccccuc ucuuauccuc agacagaugu guuucugguc      240

ugcuucagcg ugguuucccc cucuagcuuu gaaaacguga aagagaagug ggucccugaa      300

auuacccacc auugucccaa aacgccuuuc cuucuggugg ggacccagau cgaccuccgc      360

gaugacccgu ccacaauuga gaagcuggcg aagaauaaac agaagcccau caccccugag      420

acagcugaaa aacuggccag agaucucaag gccgugaaau acgucgagug cucugcucug      480

acccaaaagg gacuuaagaa cguuuuugac gaagccaucc uggcugcccu cgagcccccu      540

gagcccaaaa agagccggcg cugugugcug cuuuga                                576


<210>  7814
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__A0A024RAE6

<400>  7814

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
            180                 185                 190     


<210>  7815
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__EAW95006

<400>  7815
augcagacaa uuaagugugu uguugugggc gauggugcug uugguaaaac augucuccug       60

auauccuaca caacaaacaa auuuccaucg gaauauguac cgacuguuuu ugacaacuau      120

gcagucacag uuaugauugg uggagaacca uauacucuug gacuuuuuga uacugcaggg      180

caagaggauu augacagauu acgaccgcug aguuauccac aaacagaugu auuucuaguc      240

uguuuuucag uggucucucc aucuucauuu gaaaacguga aagaaaagug ggugccugag      300

auaacucacc acuguccaaa gacuccuuuc uugcuuguug ggacucaaau ugaucucaga      360

gaugaccccu cuacuauuga gaaacuugcc aagaacaaac agaagccuau cacuccagag      420

acugcugaaa agcuggcccg ugaccugaag gcugucaagu auguggagug uucugcacuu      480

acacagagag gucugaagaa uguguuugau gaggcuaucc uagcugcccu cgagccuccg      540

gaaacucaac ccaaaaggaa gugcuguaua uucuaa                                576


<210>  7816
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cdc42__Homo_sapiens__EAW95006

<400>  7816
augcagacca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca cgaccaacaa guuccccucc gaguacgucc cgaccguguu cgacaacuac      120

gccgugaccg ucaugaucgg gggcgagccc uacacgcugg ggcuguucga caccgcgggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucuccg ucgugagccc guccagcuuc gagaacguga aggagaagug gguccccgag      300

aucacccacc acugccccaa gacgcccuuc cuccuggugg gcacccagau cgaccugcgc      360

gacgacccgu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

acggccgaga agcuggcccg ggaccugaag gccgugaagu acgucgagug cagcgcgcuc      480

acccagcgcg ggcugaagaa cguguucgac gaggccaucc uggccgcccu cgagcccccg      540

gagacccagc ccaagcggaa gugcugcauc uucuga                                576


<210>  7817
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cdc42__Homo_sapiens__EAW95006

<400>  7817
augcagacca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacaa guuccccucc gaguacgucc ccaccgucuu cgacaacuac      120

gccgucaccg ucaugaucgg cggcgagccc uacacccucg gccucuucga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgacgu cuuccucguc      240

ugcuucuccg ucgucucccc cuccuccuuc gagaacguca aggagaagug gguccccgag      300

aucacccacc acugccccaa gacccccuuc cuccucgucg gcacccagau cgaccuccgc      360

gacgaccccu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcucgcccg cgaccucaag gccgucaagu acgucgagug cuccgcccuc      480

acccagcgcg gccucaagaa cgucuucgac gaggccaucc ucgccgcccu cgagcccccc      540

gagacccagc ccaagcgcaa gugcugcauc uucuga                                576


<210>  7818
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cdc42__Homo_sapiens__EAW95006

<400>  7818
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cuacgaacaa guuccccucc gaguauguac cuaccguguu ugauaauuac      120

gcugucacag ugaugauagg uggcgaacca uauacucuug ggcuguucga caccgcagga      180

caagaggauu acgacagauu gaggccguua ucuuaucccc agacagaugu uuuucuggug      240

ugcuucucag ucgugagucc uagcuccuuu gaaaacguaa aagagaagug gguuccagaa      300

aucacccacc auugucccaa aacuccuuuc cuacucgugg gcacacagau ugaccugcgg      360

gaugacccau cuaccaucga gaaacuugcc aagaauaagc agaagcccau uacgccugag      420

acugcggaaa aacuggcucg cgauuugaag gccgucaaau acguggagug cucggcacuc      480

acccaacgag gucugaagaa cguguuugac gaagccaucc uggcugcacu cgagccaccg      540

gagacacagc ccaagcguaa auguugcaua uucuga                                576


<210>  7819
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cdc42__Homo_sapiens__EAW95006

<400>  7819
augcagacca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacaa guuccccagc gaguacgugc ccaccguguu cgacaacuac      120

gccgugaccg ugaugaucgg cggcgagccc uacacccugg gccuguucga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucagcg uggugagccc cagcagcuuc gagaacguga aggagaagug ggugcccgag      300

aucacccacc acugccccaa gacccccuuc cugcuggugg gcacccagau cgaccugaga      360

gacgacccca gcaccaucga gaagcuggcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcuggccag agaccugaag gccgugaagu acguggagug cagcgcccug      480

acccagagag gccugaagaa cguguucgac gaggccaucc uggccgcccu ggagcccccc      540

gagacccagc ccaagagaaa gugcugcauc uucuga                                576


<210>  7820
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cdc42__Homo_sapiens__EAW95006

<400>  7820
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cgaccaacaa guuccccucc gaguaugugc cuacagucuu ugauaauuac      120

gcugugaccg uuaugaucgg cggggaaccg uauacacugg gacuuuucga caccgccggc      180

caagaggauu acgacagacu gcggccccuc ucuuauccuc agacagaugu guuucugguc      240

ugcuucagcg ugguuucccc cucuagcuuu gaaaacguga aagagaagug ggucccugaa      300

auuacccacc auugucccaa aacgccuuuc cuucuggugg ggacccagau cgaccuccgc      360

gaugacccgu ccacaauuga gaagcuggcg aagaauaaac agaagcccau caccccugag      420

acagcugaaa aacuggccag agaucucaag gccgugaaau acgucgagug cucugcucug      480

acccaacggg gacuuaagaa cguuuuugac gaagccaucc uggcugcccu cgagcccccu      540

gagacgcagc ccaagcgcaa auguugcauu uucuga                                576


<210>  7821
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__P60953

<400>  7821

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  7822
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Cdc42__Homo_sapiens__AAA52592

<400>  7822
augcagacaa uuaagugugu uguugugggc gauggugcug uugguaaaac augucuccug       60

auauccuaca caacaaacaa auuuccaucg gaauauguac cgacuguuuu ugacaacuau      120

gcagucacag uuaugauugg uggagaacca uauacucuug gacuuuuuga uacugcaggg      180

caagaggauu augacagauu acgaccgcug aguuauccac aaacagaugu auuucuaguc      240

uguuuuucag uggucucucc aucuucauuu gaaaacguga aagaaaagug ggugccugag      300

auaacucacc acuguccaaa gacuccuuuc uugcuuguug ggacucaaau ugaucucaga      360

gaugaccccu cuacuauuga gaaacuugcc aagaacaaac agaagccuau cacuccagag      420

acugcugaaa agcuggcccg ugaccugaag gcugucaagu auguggagug uucugcacuu      480

acacagaaag gccuaaagaa uguauuugac gaagcaauau uggcugcccu ggagccucca      540

gaaccgaaga agagccgcag gugugugcug cuauga                                576


<210>  7823
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Cdc42__Homo_sapiens__AAA52592

<400>  7823
augcagacca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca cgaccaacaa guuccccucc gaguacgucc cgaccguguu cgacaacuac      120

gccgugaccg ucaugaucgg gggcgagccc uacacgcugg ggcuguucga caccgcgggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucuccg ucgugagccc guccagcuuc gagaacguga aggagaagug gguccccgag      300

aucacccacc acugccccaa gacgcccuuc cuccuggugg gcacccagau cgaccugcgc      360

gacgacccgu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

acggccgaga agcuggcccg ggaccugaag gccgugaagu acgucgagug cagcgcgcuc      480

acccagaagg ggcugaagaa cguguucgac gaggccaucc uggccgcccu cgagcccccg      540

gagcccaaga agucccgccg gugcgugcug cuguga                                576


<210>  7824
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Cdc42__Homo_sapiens__AAA52592

<400>  7824
augcagacca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacaa guuccccucc gaguacgucc ccaccgucuu cgacaacuac      120

gccgucaccg ucaugaucgg cggcgagccc uacacccucg gccucuucga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgacgu cuuccucguc      240

ugcuucuccg ucgucucccc cuccuccuuc gagaacguca aggagaagug gguccccgag      300

aucacccacc acugccccaa gacccccuuc cuccucgucg gcacccagau cgaccuccgc      360

gacgaccccu ccaccaucga gaagcucgcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcucgcccg cgaccucaag gccgucaagu acgucgagug cuccgcccuc      480

acccagaagg gccucaagaa cgucuucgac gaggccaucc ucgccgcccu cgagcccccc      540

gagcccaaga agucccgccg cugcguccuc cucuga                                576


<210>  7825
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Cdc42__Homo_sapiens__AAA52592

<400>  7825
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cuacgaacaa guuccccucc gaguauguac cuaccguguu ugauaauuac      120

gcugucacag ugaugauagg uggcgaacca uauacucuug ggcuguucga caccgcagga      180

caagaggauu acgacagauu gaggccguua ucuuaucccc agacagaugu uuuucuggug      240

ugcuucucag ucgugagucc uagcuccuuu gaaaacguaa aagagaagug gguuccagaa      300

aucacccacc auugucccaa aacuccuuuc cuacucgugg gcacacagau ugaccugcgg      360

gaugacccau cuaccaucga gaaacuugcc aagaauaagc agaagcccau uacgccugag      420

acugcggaaa aacuggcucg cgauuugaag gccgucaaau acguggagug cucggcacuc      480

acccaaaagg gucugaagaa cguguuugac gaagccaucc uggcugcacu cgagccaccg      540

gagcccaaaa agucacgacg uugugucuua cuguga                                576


<210>  7826
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Cdc42__Homo_sapiens__AAA52592

<400>  7826
augcagacca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacaa guuccccagc gaguacgugc ccaccguguu cgacaacuac      120

gccgugaccg ugaugaucgg cggcgagccc uacacccugg gccuguucga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccgacgu guuccuggug      240

ugcuucagcg uggugagccc cagcagcuuc gagaacguga aggagaagug ggugcccgag      300

aucacccacc acugccccaa gacccccuuc cugcuggugg gcacccagau cgaccugaga      360

gacgacccca gcaccaucga gaagcuggcc aagaacaagc agaagcccau cacccccgag      420

accgccgaga agcuggccag agaccugaag gccgugaagu acguggagug cagcgcccug      480

acccagaagg gccugaagaa cguguucgac gaggccaucc uggccgcccu ggagcccccc      540

gagcccaaga agagcagaag augcgugcug cuguga                                576


<210>  7827
<211>  576
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Cdc42__Homo_sapiens__AAA52592

<400>  7827
augcagacca ucaagugcgu ggucguuggc gacggggccg ugggaaaaac augucugcuc       60

auuagcuaca cgaccaacaa guuccccucc gaguaugugc cuacagucuu ugauaauuac      120

gcugugaccg uuaugaucgg cggggaaccg uauacacugg gacuuuucga caccgccggc      180

caagaggauu acgacagacu gcggccccuc ucuuauccuc agacagaugu guuucugguc      240

ugcuucagcg ugguuucccc cucuagcuuu gaaaacguga aagagaagug ggucccugaa      300

auuacccacc auugucccaa aacgccuuuc cuucuggugg ggacccagau cgaccuccgc      360

gaugacccgu ccacaauuga gaagcuggcg aagaauaaac agaagcccau caccccugag      420

acagcugaaa aacuggccag agaucucaag gccgugaaau acgucgagug cucugcucug      480

acccaaaagg gacuuaagaa cguuuuugac gaagccaucc uggcugcccu cgagcccccu      540

gagcccaaaa agagccggcg cugugugcug cuuuga                                576


<210>  7828
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CFAD__Homo_sapiens__P00746

<400>  7828

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  7829
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CFAD__Homo_sapiens__CCDS12046.1

<400>  7829
augcacagcu gggagcgccu ggcaguucug guccuccuag gagcggccgc cugcgcggcg       60

ccgccccgug gucggauccu gggcggcaga gaggccgagg cgcacgcgcg gcccuacaug      120

gcgucggugc agcugaacgg cgcgcaccug ugcggcggcg uccugguggc ggagcagugg      180

gugcugagcg cggcgcacug ccuggaggac gcggccgacg ggaaggugca gguucuccug      240

ggcgcgcacu cccugucgca gccggagccc uccaagcgcc uguacgacgu gcuccgcgca      300

gugccccacc cggacagcca gcccgacacc aucgaccacg accuccugcu gcuacagcug      360

ucggagaagg ccacacuggg cccugcugug cgcccccugc ccuggcagcg cguggaccgc      420

gacguggcac cgggaacucu cugcgacgug gccggcuggg gcauagucaa ccacgcgggc      480

cgccgcccgg acagccugca gcacgugcuc uugccagugc uggaccgcgc caccugcaac      540

cggcgcacgc accacgacgg cgccaucacc gagcgcuuga ugugcgcgga gagcaaucgc      600

cgggacagcu gcaaggguga cuccgggggc ccgcuggugu gcgggggcgu gcucgagggc      660

guggucaccu cgggcucgcg cguuugcggc aaccgcaaga agcccgggau cuacacccgc      720

guggcgagcu augcggccug gaucgacagc guccuggccu ag                         762


<210>  7830
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CFAD__Homo_sapiens__CCDS12046.1

<400>  7830
augcacagcu gggagcgccu ggccgugcuc guccugcugg gcgccgcggc cugcgccgcg       60

cccccgcggg ggcgcauccu cggcgggcgg gaggccgagg cccacgcccg ccccuacaug      120

gccuccgugc agcugaacgg cgcccaccug ugcgggggcg ugcucgucgc ggagcagugg      180

gugcugagcg ccgcccacug ccuggaggac gccgccgacg gcaaggugca gguccuccug      240

ggggcgcacu cccugagcca gcccgagccc uccaagcggc ucuacgacgu gcugcgcgcc      300

gugccgcacc ccgacagcca gcccgacacc aucgaccacg accugcuccu gcugcagcuc      360

uccgagaagg ccacccuggg ccccgccguc cggccgcugc ccuggcagcg cguggaccgg      420

gacguggccc ccgggacgcu cugcgacguc gcgggcuggg ggaucgugaa ccacgccggc      480

cgccggcccg acagccugca gcacgugcug cucccggucc uggaccgcgc gaccugcaac      540

cggcgcaccc accacgacgg cgccaucacc gagcggcuga ugugcgccga guccaaccgc      600

cgggacagcu gcaaggggga cuccggcggg ccccucgugu gcggcggcgu gcuggagggg      660

gucgugacga gcggcucccg cgugugcggg aaccggaaga agcccggcau cuacacccgc      720

gucgccagcu acgccgccug gaucgacucc gugcuggccu ga                         762


<210>  7831
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CFAD__Homo_sapiens__CCDS12046.1

<400>  7831
augcacuccu gggagcgccu cgccguccuc guccuccucg gcgccgccgc cugcgccgcc       60

cccccccgcg gccgcauccu cggcggccgc gaggccgagg cccacgcccg ccccuacaug      120

gccuccgucc agcucaacgg cgcccaccuc ugcggcggcg uccucgucgc cgagcagugg      180

guccucuccg ccgcccacug ccucgaggac gccgccgacg gcaaggucca gguccuccuc      240

ggcgcccacu cccucuccca gcccgagccc uccaagcgcc ucuacgacgu ccuccgcgcc      300

gucccccacc ccgacuccca gcccgacacc aucgaccacg accuccuccu ccuccagcuc      360

uccgagaagg ccacccucgg ccccgccguc cgcccccucc ccuggcagcg cgucgaccgc      420

gacgucgccc ccggcacccu cugcgacguc gccggcuggg gcaucgucaa ccacgccggc      480

cgccgccccg acucccucca gcacguccuc cuccccgucc ucgaccgcgc caccugcaac      540

cgccgcaccc accacgacgg cgccaucacc gagcgccuca ugugcgccga guccaaccgc      600

cgcgacuccu gcaagggcga cuccggcggc ccccucgucu gcggcggcgu ccucgagggc      660

gucgucaccu ccggcucccg cgucugcggc aaccgcaaga agcccggcau cuacacccgc      720

gucgccuccu acgccgccug gaucgacucc guccucgccu ga                         762


<210>  7832
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CFAD__Homo_sapiens__CCDS12046.1

<400>  7832
augcacagcu gggagagacu ggccgugcuc guccuucugg gcgcugcagc cugcgcggcu       60

cccccuaggg ggcggaucuu gggaggucgc gaagccgagg cacaugcccg accauacaug      120

gcuuccguuc aguuaaacgg cgcacaccug ugugggggag ugcuaguagc cgaacaaugg      180

gugcucucug cugcccauug ccuggaggac gcggcagaug gcaaggucca ggugcuucug      240

ggugcccacu cauugaguca gccggaaccc agcaaacguc ucuaugacgu ucugagagcu      300

gugccucauc cagauuccca gcccgacacc auugaucacg accugcucuu acugcaacuu      360

ucugagaagg ccacauuggg gccugcaguc aggccacugc ccuggcagcg gguggaucgc      420

gacguagcuc cuggaacucu augugauguu gccggcuggg gcauagugaa ucacgcgggg      480

agaaggccag acucgcucca gcauguccug cuuccggugc uggaucgggc cacgugcaac      540

cgccgaaccc accaugacgg agcaaucaca gagagauuga ugugugcuga aucaaauagg      600

cgggauagcu gcaaagguga caguggcggg ccccucgugu guggaggcgu ccuggagggu      660

guugugacuu ccgggucucg uguaugcgga aaccgcaaga aaccuggcau uuacaccaga      720

guggccagcu augcugccug gaucgacucc gucuuagcau ga                         762


<210>  7833
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CFAD__Homo_sapiens__CCDS12046.1

<400>  7833
augcacagcu gggagagacu ggccgugcug gugcugcugg gcgccgccgc cugcgccgcc       60

ccccccagag gcagaauccu gggcggcaga gaggccgagg cccacgccag acccuacaug      120

gccagcgugc agcugaacgg cgcccaccug ugcggcggcg ugcugguggc cgagcagugg      180

gugcugagcg ccgcccacug ccuggaggac gccgccgacg gcaaggugca ggugcugcug      240

ggcgcccaca gccugagcca gcccgagccc agcaagagac uguacgacgu gcugagagcc      300

gugccccacc ccgacagcca gcccgacacc aucgaccacg accugcugcu gcugcagcug      360

agcgagaagg ccacccuggg ccccgccgug agaccccugc ccuggcagag aguggacaga      420

gacguggccc ccggcacccu gugcgacgug gccggcuggg gcaucgugaa ccacgccggc      480

agaagacccg acagccugca gcacgugcug cugcccgugc uggacagagc caccugcaac      540

agaagaaccc accacgacgg cgccaucacc gagagacuga ugugcgccga gagcaacaga      600

agagacagcu gcaagggcga cagcggcggc ccccuggugu gcggcggcgu gcuggagggc      660

guggugacca gcggcagcag agugugcggc aacagaaaga agcccggcau cuacaccaga      720

guggccagcu acgccgccug gaucgacagc gugcuggccu ga                         762


<210>  7834
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CFAD__Homo_sapiens__CCDS12046.1

<400>  7834
augcacagcu gggagagacu ggccgugcuc guccugcuug gcgcugccgc gugcgcugcu       60

cccccucggg ggcgcauccu gggaggcaga gaagccgagg cccaugcccg gccguacaug      120

gcuuccguuc agcucaacgg ggcccaccug uguggaggcg ugcuuguggc ggaacaaugg      180

guccugucug ccgcucauug ccucgaggac gccgcugaug ggaaggugca gguucugcug      240

ggagcccaca gccucuccca gcccgaaccu ucuaaacgcc uguaugacgu gcuuagagcg      300

gucccccauc cugauagcca gcccgacacc auugaucacg accugcuccu gcuucaacug      360

uccgagaagg ccacacucgg cccugcugug cggccgcugc ccuggcagcg cguugauaga      420

gacguggccc cuggcacgcu gugugauguc gcuggguggg gaaucgugaa ucacgccggc      480

cggcgccccg acucucucca gcaugugcug cuuccugucc uggauagagc uaccugcaac      540

cggcgcacac accaugacgg ggccauuacc gagagacuca ugugugcgga aagcaaucgg      600

cgcgauuccu gcaaaggaga cagcggcggg ccccugguuu guggaggcgu gcuugagggc      660

guggucacau cuggguccag agugugcgga aaccggaaga aaccgggcau cuacaccaga      720

guugccagcu augcugccug gauugacucu gugcuggccu ga                         762


<210>  7835
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CFAH__Homo_sapiens__P08603

<400>  7835

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
        995                 1000                1005            


Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
    1010                1015                1020                


Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
1025                1030                1035                1040


Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
                1045                1050                1055    


Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
            1060                1065                1070        


Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
        1075                1080                1085            


Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp 
    1090                1095                1100                


Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
1105                1110                1115                1120


Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
                1125                1130                1135    


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
            1140                1145                1150        


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
        1155                1160                1165            


Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
    1170                1175                1180                


Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
1185                1190                1195                1200


Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
                1205                1210                1215    


Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            1220                1225                1230    


<210>  7836
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CFAH__Homo_sapiens__CCDS1385.1

<400>  7836
augagacuuc uagcaaagau uauuugccuu auguuauggg cuauuugugu agcagaagau       60

ugcaaugaac uuccuccaag aagaaauaca gaaauucuga cagguuccug gucugaccaa      120

acauauccag aaggcaccca ggcuaucuau aaaugccgcc cuggauauag aucucuugga      180

aauguaauaa ugguaugcag gaagggagaa uggguugcuc uuaauccauu aaggaaaugu      240

cagaaaaggc ccuguggaca uccuggagau acuccuuuug guacuuuuac ccuuacagga      300

ggaaaugugu uugaauaugg uguaaaagcu guguauacau guaaugaggg guaucaauug      360

cuaggugaga uuaauuaccg ugaaugugac acagauggau ggaccaauga uauuccuaua      420

ugugaaguug ugaaguguuu accagugaca gcaccagaga auggaaaaau ugucaguagu      480

gcaauggaac cagaucggga auaccauuuu ggacaagcag uacgguuugu auguaacuca      540

ggcuacaaga uugaaggaga ugaagaaaug cauuguucag acgaugguuu uuggaguaaa      600

gagaaaccaa agugugugga aauuucaugc aaauccccag auguuauaaa uggaucuccu      660

auaucucaga agauuauuua uaaggagaau gaacgauuuc aauauaaaug uaacaugggu      720

uaugaauaca gugaaagagg agaugcugua ugcacugaau cuggauggcg uccguugccu      780

ucaugugaag aaaaaucaug ugauaauccu uauauuccaa auggugacua cucaccuuua      840

aggauuaaac acagaacugg agaugaaauc acguaccagu guagaaaugg uuuuuauccu      900

gcaacccggg gaaauacagc aaaaugcaca aguacuggcu ggauaccugc uccgagaugu      960

accuugaaac cuugugauua uccagacauu aaacauggag gucuauauca ugagaauaug     1020

cguagaccau acuuuccagu agcuguagga aaauauuacu ccuauuacug ugaugaacau     1080

uuugagacuc cgucaggaag uuacugggau cacauucauu gcacacaaga uggauggucg     1140

ccagcaguac caugccucag aaaauguuau uuuccuuauu uggaaaaugg auauaaucaa     1200

aaucauggaa gaaaguuugu acaggguaaa ucuauagacg uugccugcca uccuggcuac     1260

gcucuuccaa aagcgcagac cacaguuaca uguauggaga auggcugguc uccuacuccc     1320

agaugcaucc gugucaaaac auguuccaaa ucaaguauag auauugagaa uggguuuauu     1380

ucugaaucuc aguauacaua ugccuuaaaa gaaaaagcga aauaucaaug caaacuagga     1440

uauguaacag cagaugguga aacaucagga ucaauuacau gugggaaaga uggaugguca     1500

gcucaaccca cgugcauuaa aucuugugau aucccaguau uuaugaaugc cagaacuaaa     1560

aaugacuuca caugguuuaa gcugaaugac acauuggacu augaaugcca ugaugguuau     1620

gaaagcaaua cuggaagcac cacugguucc auagugugug guuacaaugg uuggucugau     1680

uuacccauau guuaugaaag agaaugcgaa cuuccuaaaa uagauguaca cuuaguuccu     1740

gaucgcaaga aagaccagua uaaaguugga gagguguuga aauucuccug caaaccagga     1800

uuuacaauag uuggaccuaa uuccguucag ugcuaccacu uuggauuguc uccugaccuc     1860

ccaauaugua aagagcaagu acaaucaugu gguccaccuc cugaacuccu caaugggaau     1920

guuaaggaaa aaacgaaaga agaauaugga cacagugaag ugguggaaua uuauugcaau     1980

ccuagauuuc uaaugaaggg accuaauaaa auucaaugug uugauggaga guggacaacu     2040

uuaccagugu guauugugga ggagaguacc uguggagaua uaccugaacu ugaacauggc     2100

ugggcccagc uuucuucccc uccuuauuac uauggagauu caguggaauu caauugcuca     2160

gaaucauuua caaugauugg acacagauca auuacgugua uucauggagu auggacccaa     2220

cuuccccagu guguggcaau agauaaacuu aagaagugca aaucaucaaa uuuaauuaua     2280

cuugaggaac auuuaaaaaa caagaaggaa uucgaucaua auucuaacau aagguacaga     2340

uguagaggaa aagaaggaug gauacacaca gucugcauaa auggaagaug ggauccagaa     2400

gugaacugcu caauggcaca aauacaauua ugcccaccuc caccucagau ucccaauucu     2460

cacaauauga caaccacacu gaauuaucgg gauggagaaa aaguaucugu ucuuugccaa     2520

gaaaauuauc uaauucagga aggagaagaa auuacaugca aagauggaag auggcaguca     2580

auaccacucu guguugaaaa aauuccaugu ucacaaccac cucagauaga acacggaacc     2640

auuaauucau ccaggucuuc acaagaaagu uaugcacaug ggacuaaauu gaguuauacu     2700

ugugagggug guuucaggau aucugaagaa aaugaaacaa caugcuacau gggaaaaugg     2760

aguucuccac cucaguguga aggccuuccu uguaaaucuc caccugagau uucucauggu     2820

guuguagcuc acaugucaga caguuaucag uauggagaag aaguuacgua caaauguuuu     2880

gaagguuuug gaauugaugg gccugcaauu gcaaaaugcu uaggagaaaa auggucucac     2940

ccuccaucau gcauaaaaac agauugucuc aguuuaccua gcuuugaaaa ugccauaccc     3000

augggagaga agaaggaugu guauaaggcg ggugagcaag ugacuuacac uugugcaaca     3060

uauuacaaaa uggauggagc caguaaugua acaugcauua auagcagaug gacaggaagg     3120

ccaacaugca gagacaccuc cugugugaau ccgcccacag uacaaaaugc uuauauagug     3180

ucgagacaga ugaguaaaua uccaucuggu gagagaguac guuaucaaug uaggagcccu     3240

uaugaaaugu uuggggauga agaagugaug uguuuaaaug gaaacuggac ggaaccaccu     3300

caaugcaaag auucuacagg aaaauguggg cccccuccac cuauugacaa uggggacauu     3360

acuucauucc cguugucagu auaugcucca gcuucaucag uugaguacca augccagaac     3420

uuguaucaac uugaggguaa caagcgaaua acauguagaa auggacaaug gucagaacca     3480

ccaaaaugcu uacauccgug uguaauaucc cgagaaauua uggaaaauua uaacauagca     3540

uuaaggugga cagccaaaca gaagcuuuau ucgagaacag gugaaucagu ugaauuugug     3600

uguaaacggg gauaucgucu uucaucacgu ucucacacau ugcgaacaac auguugggau     3660

gggaaacugg aguauccaac uugugcaaaa agauag                               3696


<210>  7837
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CFAH__Homo_sapiens__CCDS1385.1

<400>  7837
augcgccugc ucgccaagau caucugccug augcuguggg ccaucugcgu ggcggaggac       60

ugcaacgagc uccccccgcg gcgcaacacc gagauccuga ccggcagcug guccgaccag      120

acguaccccg aggggaccca ggccaucuac aagugccggc ccggcuaccg cagccugggg      180

aacgucauca uggugugccg gaagggcgag uggguggccc ucaacccccu gcgcaagugc      240

cagaagcggc cgugcgggca ccccggcgac acccccuucg gcaccuucac gcugaccggg      300

ggcaacgucu ucgaguacgg ggugaaggcc guguacaccu gcaacgaggg cuaccagcuc      360

cugggggaga ucaacuaccg cgagugcgac accgacggcu ggacgaacga cauccccauc      420

ugcgaggucg ugaagugccu gccggugacc gcccccgaga acggcaagau cgucuccagc      480

gcgauggagc ccgaccggga guaccacuuc gggcaggccg ugcgcuucgu gugcaacucc      540

ggcuacaaga ucgaggggga cgaggagaug cacugcagcg acgacggcuu cugguccaag      600

gagaagccca agugcgucga gaucagcugc aaguccccgg acgugaucaa cggcagcccc      660

aucucccaga agaucaucua caaggagaac gagcgguucc aguacaagug caacaugggg      720

uacgaguaca gcgagcgcgg cgacgccgug ugcaccgagu ccggguggcg gccccucccc      780

agcugcgagg agaaguccug cgacaacccg uacaucccca acggcgacua cagcccccug      840

cgcaucaagc accggaccgg ggacgagauc acguaccagu gccgcaacgg cuucuacccc      900

gccacccggg gcaacaccgc gaagugcacc uccacggggu ggaucccggc cccccgcugc      960

acccugaagc ccugcgacua ccccgacauc aagcacggcg ggcucuacca cgagaacaug     1020

cggcgcccgu acuuccccgu cgccgugggc aaguacuaca gcuacuacug cgacgagcac     1080

uucgagaccc ccuccgggag cuacugggac cacauccacu gcacccagga cggcuggagc     1140

cccgccgugc cgugccugcg gaagugcuac uuccccuacc uggagaacgg cuacaaccag     1200

aaccacgggc gcaaguucgu ccagggcaag uccaucgacg uggccugcca ccccggguac     1260

gcgcucccga aggcccagac gaccgugacc ugcauggaga acggcuggag ccccaccccc     1320

cgcugcaucc gggucaagac gugcuccaag agcuccaucg acaucgagaa cggguucauc     1380

agcgaguccc aguacaccua cgcccugaag gagaaggcca aguaccagug caagcugggc     1440

uacgugaccg ccgacggcga gaccagcggg uccaucacgu gcggcaagga cggguggagc     1500

gcgcagccca ccugcaucaa guccugcgac aucccggugu ucaugaacgc ccgcaccaag     1560

aacgacuuca ccugguucaa gcucaacgac acgcuggacu acgagugcca cgacggcuac     1620

gagagcaaca ccggcuccac caccgggagc aucgucugcg gcuacaacgg gugguccgac     1680

cugcccaucu gcuacgagcg ggagugcgag cuccccaaga ucgacgugca ccuggucccc     1740

gaccgcaaga aggaccagua caaggugggc gaggugcuga aguucagcug caagccgggg     1800

uucacgaucg ucggccccaa cuccgugcag ugcuaccacu ucggccucag ccccgaccug     1860

cccaucugca aggagcaggu gcaguccugc gggccgcccc ccgagcugcu caacggcaac     1920

gucaaggaga agaccaagga ggaguacggg cacagcgagg ugguggagua cuacugcaac     1980

ccccgguucc ugaugaaggg cccgaacaag auccagugcg ucgacgggga guggaccacc     2040

cugcccgugu gcaucgugga ggagagcacc ugcggcgaca uccccgagcu cgagcacggc     2100

ugggcccagc uguccagccc cccguacuac uacggggacu ccgucgaguu caacugcagc     2160

gaguccuuca cgaugaucgg ccaccgcagc aucaccugca uccacggggu guggacccag     2220

cugccccagu gcguggccau cgacaagcuc aagaagugca aguccagcaa ccugaucauc     2280

cuggaggagc accucaagaa caagaaggag uucgaccaca acuccaacau ccgguaccgc     2340

ugccggggca aggaggggug gauccacacc gucugcauca acggccgcug ggaccccgag     2400

gugaacugca gcauggccca gauccagcug ugccccccgc ccccccagau cccgaacucc     2460

cacaacauga cgaccacccu gaacuaccgg gacggcgaga aggugagcgu ccucugccag     2520

gagaacuacc ugauccagga gggggaggag aucaccugca aggacggccg cuggcagucc     2580

aucccccugu gcguggagaa gauccccugc agccagcccc cgcagaucga gcacgggacg     2640

aucaacucca gccgguccag ccaggagagc uacgcgcacg gcaccaagcu cuccuacacc     2700

ugcgaggggg gcuuccgcau cagcgaggag aacgagacca cgugcuacau gggcaagugg     2760

uccagccccc cccagugcga ggggcugccc ugcaaguccc cgcccgagau cagccacggc     2820

guggucgccc acauguccga cagcuaccag uacggggagg aggugaccua caagugcuuc     2880

gagggcuucg gcaucgacgg gcccgccauc gccaagugcc ugggcgagaa guggucccac     2940

cccccgagcu gcaucaagac cgacugccuc ucccugccca gcuucgagaa cgccaucccc     3000

augggggaga agaaggacgu guacaaggcg ggcgagcagg ucaccuacac gugcgccacc     3060

uacuacaaga uggacggggc cuccaacgug accugcauca acagccggug gaccggccgc     3120

cccacgugcc gggacaccuc cugcgugaac ccgcccaccg uccagaacgc cuacaucgug     3180

agccgccaga uguccaagua ccccagcggc gagcgggugc gcuaccagug ccgcuccccc     3240

uacgagaugu ucggggacga ggaggucaug ugccugaacg gcaacuggac cgagccgccc     3300

cagugcaagg acagcacggg gaagugcggc ccccccccgc ccaucgacaa cggggacauc     3360

accagcuucc cccuguccgu guacgcgccc gccagcuccg uggaguacca gugccagaac     3420

cucuaccagc uggagggcaa caagcggauc accugccgca acggccagug gagcgagccg     3480

cccaagugcc ugcaccccug cgucaucucc cgggagauca uggagaacua caacaucgcc     3540

cuccgcugga ccgccaagca gaagcuguac agccggacgg gggaguccgu ggaguucgug     3600

ugcaagcgcg gcuaccggcu gagcucccgc agccacaccc uccggaccac cugcugggac     3660

gggaagcugg aguacccgac gugcgccaag cgcuga                               3696


<210>  7838
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CFAH__Homo_sapiens__CCDS1385.1

<400>  7838
augcgccucc ucgccaagau caucugccuc augcucuggg ccaucugcgu cgccgaggac       60

ugcaacgagc uccccccccg ccgcaacacc gagauccuca ccggcuccug guccgaccag      120

accuaccccg agggcaccca ggccaucuac aagugccgcc ccggcuaccg cucccucggc      180

aacgucauca uggucugccg caagggcgag ugggucgccc ucaacccccu ccgcaagugc      240

cagaagcgcc ccugcggcca ccccggcgac acccccuucg gcaccuucac ccucaccggc      300

ggcaacgucu ucgaguacgg cgucaaggcc gucuacaccu gcaacgaggg cuaccagcuc      360

cucggcgaga ucaacuaccg cgagugcgac accgacggcu ggaccaacga cauccccauc      420

ugcgaggucg ucaagugccu ccccgucacc gcccccgaga acggcaagau cgucuccucc      480

gccauggagc ccgaccgcga guaccacuuc ggccaggccg uccgcuucgu cugcaacucc      540

ggcuacaaga ucgagggcga cgaggagaug cacugcuccg acgacggcuu cugguccaag      600

gagaagccca agugcgucga gaucuccugc aagucccccg acgucaucaa cggcuccccc      660

aucucccaga agaucaucua caaggagaac gagcgcuucc aguacaagug caacaugggc      720

uacgaguacu ccgagcgcgg cgacgccguc ugcaccgagu ccggcuggcg cccccucccc      780

uccugcgagg agaaguccug cgacaacccc uacaucccca acggcgacua cuccccccuc      840

cgcaucaagc accgcaccgg cgacgagauc accuaccagu gccgcaacgg cuucuacccc      900

gccacccgcg gcaacaccgc caagugcacc uccaccggcu ggauccccgc cccccgcugc      960

acccucaagc ccugcgacua ccccgacauc aagcacggcg gccucuacca cgagaacaug     1020

cgccgccccu acuuccccgu cgccgucggc aaguacuacu ccuacuacug cgacgagcac     1080

uucgagaccc ccuccggcuc cuacugggac cacauccacu gcacccagga cggcuggucc     1140

cccgccgucc ccugccuccg caagugcuac uuccccuacc ucgagaacgg cuacaaccag     1200

aaccacggcc gcaaguucgu ccagggcaag uccaucgacg ucgccugcca ccccggcuac     1260

gcccucccca aggcccagac caccgucacc ugcauggaga acggcugguc ccccaccccc     1320

cgcugcaucc gcgucaagac cugcuccaag uccuccaucg acaucgagaa cggcuucauc     1380

uccgaguccc aguacaccua cgcccucaag gagaaggcca aguaccagug caagcucggc     1440

uacgucaccg ccgacggcga gaccuccggc uccaucaccu gcggcaagga cggcuggucc     1500

gcccagccca ccugcaucaa guccugcgac auccccgucu ucaugaacgc ccgcaccaag     1560

aacgacuuca ccugguucaa gcucaacgac acccucgacu acgagugcca cgacggcuac     1620

gaguccaaca ccggcuccac caccggcucc aucgucugcg gcuacaacgg cugguccgac     1680

cuccccaucu gcuacgagcg cgagugcgag cuccccaaga ucgacgucca ccucgucccc     1740

gaccgcaaga aggaccagua caaggucggc gagguccuca aguucuccug caagcccggc     1800

uucaccaucg ucggccccaa cuccguccag ugcuaccacu ucggccucuc ccccgaccuc     1860

cccaucugca aggagcaggu ccaguccugc ggcccccccc ccgagcuccu caacggcaac     1920

gucaaggaga agaccaagga ggaguacggc cacuccgagg ucgucgagua cuacugcaac     1980

ccccgcuucc ucaugaaggg ccccaacaag auccagugcg ucgacggcga guggaccacc     2040

cuccccgucu gcaucgucga ggaguccacc ugcggcgaca uccccgagcu cgagcacggc     2100

ugggcccagc ucuccucccc ccccuacuac uacggcgacu ccgucgaguu caacugcucc     2160

gaguccuuca ccaugaucgg ccaccgcucc aucaccugca uccacggcgu cuggacccag     2220

cucccccagu gcgucgccau cgacaagcuc aagaagugca aguccuccaa ccucaucauc     2280

cucgaggagc accucaagaa caagaaggag uucgaccaca acuccaacau ccgcuaccgc     2340

ugccgcggca aggagggcug gauccacacc gucugcauca acggccgcug ggaccccgag     2400

gucaacugcu ccauggccca gauccagcuc ugcccccccc ccccccagau ccccaacucc     2460

cacaacauga ccaccacccu caacuaccgc gacggcgaga aggucuccgu ccucugccag     2520

gagaacuacc ucauccagga gggcgaggag aucaccugca aggacggccg cuggcagucc     2580

aucccccucu gcgucgagaa gauccccugc ucccagcccc cccagaucga gcacggcacc     2640

aucaacuccu cccgcuccuc ccaggagucc uacgcccacg gcaccaagcu cuccuacacc     2700

ugcgagggcg gcuuccgcau cuccgaggag aacgagacca ccugcuacau gggcaagugg     2760

uccucccccc cccagugcga gggccucccc ugcaaguccc cccccgagau cucccacggc     2820

gucgucgccc acauguccga cuccuaccag uacggcgagg aggucaccua caagugcuuc     2880

gagggcuucg gcaucgacgg ccccgccauc gccaagugcc ucggcgagaa guggucccac     2940

ccccccuccu gcaucaagac cgacugccuc ucccuccccu ccuucgagaa cgccaucccc     3000

augggcgaga agaaggacgu cuacaaggcc ggcgagcagg ucaccuacac cugcgccacc     3060

uacuacaaga uggacggcgc cuccaacguc accugcauca acucccgcug gaccggccgc     3120

cccaccugcc gcgacaccuc cugcgucaac ccccccaccg uccagaacgc cuacaucguc     3180

ucccgccaga uguccaagua ccccuccggc gagcgcgucc gcuaccagug ccgcuccccc     3240

uacgagaugu ucggcgacga ggaggucaug ugccucaacg gcaacuggac cgagcccccc     3300

cagugcaagg acuccaccgg caagugcggc cccccccccc ccaucgacaa cggcgacauc     3360

accuccuucc cccucuccgu cuacgccccc gccuccuccg ucgaguacca gugccagaac     3420

cucuaccagc ucgagggcaa caagcgcauc accugccgca acggccagug guccgagccc     3480

cccaagugcc uccaccccug cgucaucucc cgcgagauca uggagaacua caacaucgcc     3540

cuccgcugga ccgccaagca gaagcucuac ucccgcaccg gcgaguccgu cgaguucguc     3600

ugcaagcgcg gcuaccgccu cuccucccgc ucccacaccc uccgcaccac cugcugggac     3660

ggcaagcucg aguaccccac cugcgccaag cgcuga                               3696


<210>  7839
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CFAH__Homo_sapiens__CCDS1385.1

<400>  7839
augagacugc ucgccaagau cauuugccuu augcuguggg cuauaugugu ggcagaggac       60

ugcaacgaau ugcccccuag gcggaauacc gagaucuuaa caggcagcug guccgaucag      120

acuuacccag aagggacgca agccauuuau aaaugucgcc cgggauaccg aucucugggu      180

aacgucauca ugguuugccg uaagggcgag uggguggcgc uaaauccccu cagaaaaugu      240

cagaagaggc cuugcgggca cccaggagac acccccuucg gcacauuuac ucugaccggu      300

gggaacguau ucgaauaugg agugaaagcu gucuacacau guaaugaggg cuaucagcuu      360

cugggcgaga uuaacuaccg ggaaugcgau accgacgggu ggacuaauga uaucccuaua      420

ugugaggugg uuaagugcuu gccagugaca gcccccgaaa acggaaagau cgucucaagu      480

gcaauggagc cugaccgcga guaucauuuu ggucaggccg ugagauucgu auguaauagc      540

ggcuacaaaa uugaagggga ugaggaaaug cacugcuccg acgauggauu uuggucuaag      600

gagaaaccaa agugcguuga aaucucgugu aaaucaccgg acgugauuaa cggcagcccc      660

aucagucaaa agauaauuua caaggagaau gagagguucc aguauaaaug caacaugggu      720

uacgaauauu ccgagcgcgg ggaugcuguc uguaccgaau cuggauggcg gccucuccca      780

agcugcgagg aaaaguccug ugacaauccc uacaucccua acggcgauua uucaccacug      840

cgaauuaaac auagaacggg cgacgagauc acuuaccagu gcaggaaugg guuuuauccc      900

gcaacccggg gaaacacagc caaguguacu uccaccgguu ggaucccggc uccucguugc      960

acacugaaac ccugugacua cccagauauu aagcacggcg ggcucuacca ugagaacaug     1020

cgcagaccuu auuuccccgu ggccguggga aaauacuaua gcuacuauug cgacgaacac     1080

uuugagaccc caucuggcuc cuacugggau cacauacauu guacgcagga cgguugguca     1140

cccgcggucc cuugcuuaag gaagugcuau uucccauacc uggaaaaugg guacaaccaa     1200

aaucacggcc ggaaguuugu ucagggaaaa agcaucgaug uggcauguca uccgggcuau     1260

gcccuuccca aggcucagac uacaguaacc ugcauggaga acggguggag uccuacucca     1320

cgauguauuc gcgugaaaac augcucuaag uccagcaucg acauagaaaa uggauucauu     1380

ucggagucuc aguacaccua ugccuugaaa gagaaggcaa aguaccaaug uaaacugggu     1440

uaugucacgg cugauggcga aaccuccggg ucaaucacau gcggaaagga cggcuggagu     1500

gcccagccca cuuguaucaa aagcugcgau auuccugugu uuaugaacgc gagaaccaag     1560

aaugacuuca caugguucaa acuaaacgau acucucgacu acgaguguca cgacgguuau     1620

gaauccaaua ccgggucuac aaccggcagc aucguuugcg gauacaacgg cuggucagau     1680

cugccaauuu guuacgagag ggagugcgaa cuucccaaga uagacgugca ccuggucccg     1740

gaucggaaga aagaccagua uaaggugggg gagguauuga aauuuaguug caagccugga     1800

uucacuaucg uugguccaaa uuccgugcaa uguuaccauu uuggccucag ccccgaucug     1860

ccuauuugca aagaacaggu ccagucuugu gggcccccac cugaguuacu gaacggaaau     1920

gugaaggaaa agacgaaaga ggaguauggc cacucagaag ucguggagua cuauugcaac     1980

ccccgcuucc ucaugaaggg uccaaauaaa auccagugug uugacgggga auggacaacc     2040

cuuccggugu gcaucguaga ggaaaguacu uguggcgaua uuccugagcu ggagcaugga     2100

ugggcccaau ugagcagucc cccauacuau uacggcgacu cugucgaauu uaacugcucg     2160

gagagcuuca ccaugauagg gcacagaucc aucacaugua uucauggagu guggacccag     2220

cuaccccagu gcguugcaau cgauaagcug aaaaagugua aaucaaguaa ccucauuauc     2280

cuggaagaac accuuaagaa uaagaaagaa uuugaccaca acucuaauau aagguaccgu     2340

ugccggggca aggaggguug gauccauacu gugugcauua acgggcgaug ggauccugag     2400

gucaauugua gcauggcuca gauccaacug ugcccacccc cuccgcagau uccaaacucc     2460

cacaauauga caacgaccuu gaacuauaga gacggagaaa aagugucagu acucugucag     2520

gagaauuacc ugauccagga aggcgaggag auaacuugca aggaugguag guggcaaagc     2580

auucccuuau guguggagaa aaucccuugc ucucagccac cccagauuga gcauggcaca     2640

aucaacucca gucgcagcuc ucaggaaucc uaugcccacg ggaccaagcu gucauacaca     2700

ugugagggag gcuuccggau aagugaagag aaugagacua ccugcuauau ggggaagugg     2760

agcucgccuc cgcaauguga aggacuaccc ugcaaauccc caccugagau cucucacggc     2820

guugucgcuc auaugagcga cucauaccag uauggugaag aggugacgua caaguguuuu     2880

gaaggguucg gaauugacgg ccccgccauc gcaaaaugcc ucggugagaa guggagucac     2940

ccaccuuccu gcauuaaaac cgauugucug ucucuuccca gcuuugagaa cgccauccca     3000

augggcgaaa agaaggacgu guacaaagcu ggggagcagg ucacauauac uugcgcgacc     3060

uacuauaaga uggauggagc auccaauguu acauguauaa acucaagaug gacuggcagg     3120

ccgaccugcc gcgacacgag cugugugaau ccucccacag ugcaaaacgc cuacauugua     3180

agucgacaga ugucuaaaua uccauccggg gaacgggucc guuaccagug cagaagcccc     3240

uaugagaugu ucggagauga agaggugaug uguuugaacg gcaauuggac cgagccucca     3300

cagugcaagg acucgacugg uaaauguggg cccccuccgc caaucgauaa cggagacauc     3360

acaucauuuc cccugucugu uuacgcuccu gccaguuccg uggaauacca augccagaau     3420

cucuaucagc uggagggcaa caagaggauu accugucgca auggucagug gagcgaaccc     3480

ccaaagugcc uucauccuug cgucaucucu cgggagauua uggagaacua caauauagca     3540

cugagaugga cugccaaaca aaaguuguau agcaggaccg gcgaauccgu ggaguucguu     3600

uguaaacgag gguaccgccu cucaagucgg agccacacac ugagaacgac cugcugggau     3660

ggaaaguuag aauaucccac uugugcuaaa agguga                               3696


<210>  7840
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CFAH__Homo_sapiens__CCDS1385.1

<400>  7840
augagacugc uggccaagau caucugccug augcuguggg ccaucugcgu ggccgaggac       60

ugcaacgagc ugccccccag aagaaacacc gagauccuga ccggcagcug gagcgaccag      120

accuaccccg agggcaccca ggccaucuac aagugcagac ccggcuacag aagccugggc      180

aacgugauca uggugugcag aaagggcgag uggguggccc ugaacccccu gagaaagugc      240

cagaagagac ccugcggcca ccccggcgac acccccuucg gcaccuucac ccugaccggc      300

ggcaacgugu ucgaguacgg cgugaaggcc guguacaccu gcaacgaggg cuaccagcug      360

cugggcgaga ucaacuacag agagugcgac accgacggcu ggaccaacga cauccccauc      420

ugcgaggugg ugaagugccu gcccgugacc gcccccgaga acggcaagau cgugagcagc      480

gccauggagc ccgacagaga guaccacuuc ggccaggccg ugagauucgu gugcaacagc      540

ggcuacaaga ucgagggcga cgaggagaug cacugcagcg acgacggcuu cuggagcaag      600

gagaagccca agugcgugga gaucagcugc aagagccccg acgugaucaa cggcagcccc      660

aucagccaga agaucaucua caaggagaac gagagauucc aguacaagug caacaugggc      720

uacgaguaca gcgagagagg cgacgccgug ugcaccgaga gcggcuggag accccugccc      780

agcugcgagg agaagagcug cgacaacccc uacaucccca acggcgacua cagcccccug      840

agaaucaagc acagaaccgg cgacgagauc accuaccagu gcagaaacgg cuucuacccc      900

gccaccagag gcaacaccgc caagugcacc agcaccggcu ggauccccgc ccccagaugc      960

acccugaagc ccugcgacua ccccgacauc aagcacggcg gccuguacca cgagaacaug     1020

agaagacccu acuuccccgu ggccgugggc aaguacuaca gcuacuacug cgacgagcac     1080

uucgagaccc ccagcggcag cuacugggac cacauccacu gcacccagga cggcuggagc     1140

cccgccgugc ccugccugag aaagugcuac uuccccuacc uggagaacgg cuacaaccag     1200

aaccacggca gaaaguucgu gcagggcaag agcaucgacg uggccugcca ccccggcuac     1260

gcccugccca aggcccagac caccgugacc ugcauggaga acggcuggag ccccaccccc     1320

agaugcauca gagugaagac cugcagcaag agcagcaucg acaucgagaa cggcuucauc     1380

agcgagagcc aguacaccua cgcccugaag gagaaggcca aguaccagug caagcugggc     1440

uacgugaccg ccgacggcga gaccagcggc agcaucaccu gcggcaagga cggcuggagc     1500

gcccagccca ccugcaucaa gagcugcgac auccccgugu ucaugaacgc cagaaccaag     1560

aacgacuuca ccugguucaa gcugaacgac acccuggacu acgagugcca cgacggcuac     1620

gagagcaaca ccggcagcac caccggcagc aucgugugcg gcuacaacgg cuggagcgac     1680

cugcccaucu gcuacgagag agagugcgag cugcccaaga ucgacgugca ccuggugccc     1740

gacagaaaga aggaccagua caaggugggc gaggugcuga aguucagcug caagcccggc     1800

uucaccaucg ugggccccaa cagcgugcag ugcuaccacu ucggccugag ccccgaccug     1860

cccaucugca aggagcaggu gcagagcugc ggcccccccc ccgagcugcu gaacggcaac     1920

gugaaggaga agaccaagga ggaguacggc cacagcgagg ugguggagua cuacugcaac     1980

cccagauucc ugaugaaggg ccccaacaag auccagugcg uggacggcga guggaccacc     2040

cugcccgugu gcaucgugga ggagagcacc ugcggcgaca uccccgagcu ggagcacggc     2100

ugggcccagc ugagcagccc ccccuacuac uacggcgaca gcguggaguu caacugcagc     2160

gagagcuuca ccaugaucgg ccacagaagc aucaccugca uccacggcgu guggacccag     2220

cugccccagu gcguggccau cgacaagcug aagaagugca agagcagcaa ccugaucauc     2280

cuggaggagc accugaagaa caagaaggag uucgaccaca acagcaacau cagauacaga     2340

ugcagaggca aggagggcug gauccacacc gugugcauca acggcagaug ggaccccgag     2400

gugaacugca gcauggccca gauccagcug ugcccccccc ccccccagau ccccaacagc     2460

cacaacauga ccaccacccu gaacuacaga gacggcgaga aggugagcgu gcugugccag     2520

gagaacuacc ugauccagga gggcgaggag aucaccugca aggacggcag auggcagagc     2580

aucccccugu gcguggagaa gauccccugc agccagcccc cccagaucga gcacggcacc     2640

aucaacagca gcagaagcag ccaggagagc uacgcccacg gcaccaagcu gagcuacacc     2700

ugcgagggcg gcuucagaau cagcgaggag aacgagacca ccugcuacau gggcaagugg     2760

agcagccccc cccagugcga gggccugccc ugcaagagcc cccccgagau cagccacggc     2820

gugguggccc acaugagcga cagcuaccag uacggcgagg aggugaccua caagugcuuc     2880

gagggcuucg gcaucgacgg ccccgccauc gccaagugcc ugggcgagaa guggagccac     2940

ccccccagcu gcaucaagac cgacugccug agccugccca gcuucgagaa cgccaucccc     3000

augggcgaga agaaggacgu guacaaggcc ggcgagcagg ugaccuacac cugcgccacc     3060

uacuacaaga uggacggcgc cagcaacgug accugcauca acagcagaug gaccggcaga     3120

cccaccugca gagacaccag cugcgugaac ccccccaccg ugcagaacgc cuacaucgug     3180

agcagacaga ugagcaagua ccccagcggc gagagaguga gauaccagug cagaagcccc     3240

uacgagaugu ucggcgacga ggaggugaug ugccugaacg gcaacuggac cgagcccccc     3300

cagugcaagg acagcaccgg caagugcggc cccccccccc ccaucgacaa cggcgacauc     3360

accagcuucc cccugagcgu guacgccccc gccagcagcg uggaguacca gugccagaac     3420

cuguaccagc uggagggcaa caagagaauc accugcagaa acggccagug gagcgagccc     3480

cccaagugcc ugcaccccug cgugaucagc agagagauca uggagaacua caacaucgcc     3540

cugagaugga ccgccaagca gaagcuguac agcagaaccg gcgagagcgu ggaguucgug     3600

ugcaagagag gcuacagacu gagcagcaga agccacaccc ugagaaccac cugcugggac     3660

ggcaagcugg aguaccccac cugcgccaag agauga                               3696


<210>  7841
<211>  3696
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CFAH__Homo_sapiens__CCDS1385.1

<400>  7841
augagacugc ucgccaagau cauuugccug augcuuuggg cuaucugugu ggccgaggac       60

ugcaacgaac ugcccccucg gcgcaauacc gagauucuca caggcagcug guccgaucag      120

acguacccgg aagggaccca agcgaucuau aaauguagac ccggauaccg gucucugggc      180

aacgucauua ugguuugccg caagggggag uggguggcuc uuaauccucu gagaaaaugu      240

cagaagcggc ccugcggaca cccuggcgac acacccuucg ggaccuuuac acucaccgga      300

ggcaacgugu ucgaauaugg cgucaaagcc guguacacau guaaugaggg guaucagcug      360

cugggagaga ucaacuaccg cgaaugcgau accgacggcu ggacgaauga uaucccuauu      420

ugugagguug ugaagugccu cccggucacc gcccccgaaa acgggaagau cgugagcucc      480

gcuauggagc cugacagaga guaucauuuu ggacaggccg uucgguucgu guguaauucu      540

ggcuacaaaa uugaagggga ugaggaaaug cacugcagcg acgauggauu uugguccaag      600

gagaaaccca agugcgucga aaucucuugu aaaagcccug acgugauuaa cggcuccccc      660

aucagccaaa agauuaucua caaggagaau gagcgcuucc aguauaaaug caacaugggc      720

uacgaauauu cugagagagg ggaugcugug uguacagaau ccggauggcg gccgcugccu      780

agcugcgagg aaaagucuug ugacaauccc uacaucccua acggcgauua uagcccccuu      840

cgcauuaaac auagaaccgg ggacgagauc acauaccagu gccggaaugg auuuuauccc      900

gccacccgcg gcaacacggc gaaguguaca uccaccgggu ggauuccugc cccgagaugc      960

acacugaaac ccugugacua cccugauauc aagcacggag gccucuacca ugagaacaug     1020

cggagacccu auuucccugu cgcuguuggc aaauacuauu cuuacuauug cgacgaacac     1080

uuugagaccc ccuccgggag cuacugggau cacauucauu guacccagga cggauggucc     1140

ccggccgugc cuugccugcg caagugcuau uuccccuacc uugaaaaugg cuacaaccaa     1200

aaucacgggc ggaaguuugu gcagggaaaa ucuaucgaug ucgcuuguca uccuggcuau     1260

gcccugccca aggcgcagac aacggugacc ugcauggaga acggguggag cccuacaccc     1320

agauguaucc gcguuaaaac cugcuccaag agcucuauug acaucgaaaa uggcuucauu     1380

uccgagagcc aguacacaua ugcccucaaa gagaaggcua aguaccaaug uaaacuggga     1440

uaugugaccg ccgauggcga aacgucuggg agcaucacau gcggaaagga cggcuggucc     1500

gcucagccga ccuguauuaa aucuugcgau aucccugucu uuaugaacgc ccggaccaag     1560

aaugacuuca caugguucaa acugaacgau acccucgacu acgaguguca cgacggguau     1620

gaaagcaaua caggauccac gaccggcagc aucgugugcg gguacaacgg cuggucugau     1680

cugcccauuu guuacgagag agagugcgaa cuucccaaga ucgacguuca ccuggugccu     1740

gaucgcaaga aagaccagua uaaggucgga gaggugcuca aauuuuccug caagccgggc     1800

uucacaauug ucgggcccaa uagcgugcaa uguuaccauu uuggacuguc uccugaucuu     1860

cccaucugca aagaacaggu ucaguccugu ggcccucccc cugagcugcu caacgggaau     1920

gugaaggaaa agaccaaaga ggaguaugga cacagcgaag ucguggagua cuauugcaac     1980

ccccgguucc ugaugaaggg cccgaauaaa auucagugug uugacgggga auggacaacc     2040

cugccugugu gcaucgucga ggaauccacg uguggcgaua uucccgagcu cgagcaugga     2100

ugggcccaac ugucuagccc ucccuacuau uacggcgacu ccguggaauu uaacugcucu     2160

gagagcuuca ccaugaucgg gcacagaucc aucacaugua uucauggagu guggacccag     2220

cuuccgcagu gcguugcuau cgauaagcug aaaaagugua aaagcucuaa ccucauuauc     2280

cuggaggagc accuuaagaa uaagaaagaa uuugaccaca acuccaauau ucgcuaccgg     2340

ugcagaggca aggaggggug gauccauaca gucugcauca acggacgcug ggauccugag     2400

gugaauugua gcauggcgca gauucaacug ugucccccuc cuccccagau ccccaacucu     2460

cacaauauga ccacgacacu caacuaucgg gacggcgaaa aaguguccgu ccugugccag     2520

gagaauuacc ugauucagga aggggaggag auuaccugca aggauggcag auggcaaagc     2580

aucccgcucu guguggagaa aauccccugc ucucagccuc cccagaucga acauggaaca     2640

auuaacagcu cccggagcuc ucaggaaucc uaugcccacg gcaccaagcu gagcuacacc     2700

ugugaagggg gauuccgcau cuccgaagag aaugagacaa cgugcuauau gggcaagugg     2760

ucuagcccuc cccaauguga agggcuuccu ugcaaauccc cgcccgagau uucucacgga     2820

guuguggcuc auaugagcga cuccuaccag uauggcgaag aggucaccua caaguguuuu     2880

gaaggcuucg ggaucgacgg accugccauu gccaaaugcc ugggcgagaa guggucucau     2940

cccccuagcu gcaucaaaac agauugucuc ucccugccca gcuuugagaa cgcuaucccg     3000

augggggaaa agaaggacgu guacaaagcc ggagagcagg uuaccuauac augcgcgacc     3060

uacuauaaga uggauggcgc uucuaaugug acguguauua acuccagaug gacagggcgg     3120

ccuaccugca gagacaccag cugugucaau ccucccacag ugcaaaacgc cuacaucguu     3180

ucucgccaga uguccaaaua ucccagcgga gaacggguga gauaccagug ccgcucuccc     3240

uaugagaugu ucggcgauga agaggucaug ugucugaacg gcaauuggac cgagccuccg     3300

cagugcaagg acuccacagg gaaaugugga cccccucccc cuauugauaa cggcgacauc     3360

acgagcuuuc cccuuuccgu guacgccccg gcuagcucug uggaauacca augccagaau     3420

cucuaucagc uggaggggaa caagagaauu accugucgga auggacagug gagcgaaccu     3480

cccaagugcc ugcacccuug cgucaucucc cgcgagauua uggagaacua caauaucgcc     3540

cucagaugga cagcuaaaca aaagcuguau ucucggaccg gcgaaagcgu ugaguucgug     3600

uguaaacgcg gguacagacu uuccucucgg agccacacac ugcgcaccac gugcugggau     3660

ggaaagcucg aauaucccac cugugccaaa agauga                               3696


<210>  7842
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CFAI__Homo_sapiens__P05156

<400>  7842

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  7843
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CFAI__Homo_sapiens__CCDS34049.1

<400>  7843
augaagcuuc uucauguuuu ccuguuauuu cugugcuucc acuuaagguu uugcaagguc       60

acuuauacau cucaagagga ucugguggag aaaaagugcu uagcaaaaaa auauacucac      120

cucuccugcg auaaagucuu cugccagcca uggcagagau gcauugaggg caccuguguu      180

uguaaacuac cguaucagug cccaaagaau ggcacugcag ugugugcaac uaacaggaga      240

agcuucccaa cauacuguca acaaaagagu uuggaauguc uucauccagg gacaaaguuu      300

uuaaauaacg gaacaugcac agccgaagga aaguuuagug uuuccuugaa gcauggaaau      360

acagauucag agggaauagu ugaaguaaaa cuuguggacc aagauaagac aauguucaua      420

ugcaaaagca gcuggagcau gagggaagcc aacguggccu gccuugaccu uggguuucaa      480

caaggugcug auacucaaag aagguuuaag uugucugauc ucucuauaaa uuccacugaa      540

ugucuacaug ugcauugccg aggauuagag accaguuugg cugaauguac uuuuacuaag      600

agaagaacua uggguuacca ggauuucgcu gaugugguuu guuauacaca gaaagcagau      660

ucuccaaugg augacuucuu ucagugugug aaugggaaau acauuucuca gaugaaagcc      720

ugugauggua ucaaugauug uggagaccaa agugaugaac uguguuguaa agcaugccaa      780

ggcaaaggcu uccauugcaa aucggguguu ugcauuccaa gccaguauca augcaauggu      840

gagguggacu gcauuacagg ggaagaugaa guuggcugug caggcuuugc aucugugacu      900

caagaagaaa cagaaauuuu gacugcugac auggaugcag aaagaagacg gauaaaauca      960

uuauuaccua aacuaucuug uggaguuaaa aacagaaugc acauucgaag gaaacgaauu     1020

gugggaggaa agcgagcaca acugggagac cucccauggc agguggcaau uaaggaugcc     1080

aguggaauca ccuguggggg aauuuauauu gguggcuguu ggauucugac ugcugcacau     1140

ugucucagag ccaguaaaac ucaucguuac caaauaugga caacaguagu agacuggaua     1200

caccccgacc uuaaacguau aguaauugaa uacguggaua gaauuauuuu ccaugaaaac     1260

uacaaugcag gcacuuacca aaaugacauc gcuuugauug aaaugaaaaa agacggaaac     1320

aaaaaagauu gugagcugcc ucguuccauc ccugccugug uccccugguc uccuuaccua     1380

uuccaaccua augauacaug caucguuucu ggcuggggac gagaaaaaga uaacgaaaga     1440

gucuuuucac uucagugggg ugaaguuaaa cuaauaagca acugcucuaa guuuuacgga     1500

aaucguuucu augaaaaaga aauggaaugu gcagguacau augaugguuc caucgaugcc     1560

uguaaagggg acucuggagg ccccuuaguc uguauggaug ccaacaaugu gacuuauguc     1620

ugggguguug ugaguugggg ggaaaacugu ggaaaaccag aguucccagg uguuuacacc     1680

aaaguggcca auuauuuuga cuggauuagc uaccauguag gaaggccuuu uauuucucag     1740

uacaauguau aa                                                         1752


<210>  7844
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CFAI__Homo_sapiens__CCDS34049.1

<400>  7844
augaagcugc uccacguguu ccugcuguuc cucugcuucc accuccgcuu cugcaagguc       60

accuacacca gccaggagga ccugguggag aagaagugcc uggccaagaa guacacgcac      120

cuguccugcg acaagguguu cugccagccc uggcagcggu gcaucgaggg gaccugcguc      180

ugcaagcugc cguaccagug ccccaagaac gggaccgccg ugugcgcgac caaccgccgg      240

agcuucccca cguacugcca gcagaagucc cucgagugcc ugcaccccgg caccaaguuc      300

cugaacaacg ggaccugcac cgccgagggc aaguucagcg ugucccucaa gcacgggaac      360

acggacagcg agggcaucgu cgaggugaag cugguggacc aggacaagac cauguucauc      420

ugcaagucca gcugguccau gcgcgaggcc aacgucgccu gccuggaccu cggcuuccag      480

cagggggccg acacccagcg gcgcuucaag cugagcgacc uguccaucaa cagcaccgag      540

ugccuccacg ugcacugccg gggccuggag acgucccugg cggagugcac cuucaccaag      600

cgccggacca ugggguacca ggacuucgcc gacguggucu gcuacacgca gaaggccgac      660

agcccgaugg acgacuucuu ccagugcgug aacggcaagu acaucuccca gaugaaggcc      720

ugcgacggga ucaacgacug cggcgaccag agcgacgagc ucugcugcaa ggcgugccag      780

ggcaaggggu uccacugcaa guccggcgug ugcaucccca gccaguacca gugcaacggg      840

gaggucgacu gcaucaccgg cgaggacgag gugggcugcg ccggguucgc cuccgugacc      900

caggaggaga ccgagauccu gacggccgac auggacgccg agcgccggcg caucaagagc      960

cugcucccca agcugagcug cggcgucaag aaccggaugc acauccgccg gaagcgcauc     1020

gucgggggca agcgggcgca gcugggggac cuccccuggc aggucgccau caaggacgcc     1080

uccggcauca cgugcggcgg gaucuacauc ggcgggugcu ggauccugac cgccgcccac     1140

ugccugcgcg cgagcaagac ccaccgguac cagaucugga ccaccguggu ggacuggauc     1200

cacccggacc ucaagcgcau cgugaucgag uacguggacc ggaucaucuu ccacgagaac     1260

uacaacgccg gcaccuacca gaacgacauc gcccugaucg agaugaagaa ggacgggaac     1320

aagaaggacu gcgagcugcc ccgcuccauc cccgccugcg ugcccuggag cccguaccuc     1380

uuccagccca acgacacgug caucgucucc ggcuggggcc gcgagaagga caacgagcgg     1440

guguucagcc ugcagugggg cgaggugaag cugaucucca acugcagcaa guucuacggc     1500

aaccgcuucu acgagaagga gauggagugc gccgggaccu acgacggcuc caucgacgcg     1560

ugcaaggggg acagcggcgg cccccucguc ugcauggacg ccaacaacgu gaccuacgug     1620

uggggcgucg uguccugggg cgagaacugc gggaagcccg aguucccggg gguguacacc     1680

aaggucgcca acuacuucga cuggaucagc uaccacgugg gccggcccuu caucucccag     1740

uacaacgugu ga                                                         1752


<210>  7845
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CFAI__Homo_sapiens__CCDS34049.1

<400>  7845
augaagcucc uccacgucuu ccuccucuuc cucugcuucc accuccgcuu cugcaagguc       60

accuacaccu cccaggagga ccucgucgag aagaagugcc ucgccaagaa guacacccac      120

cucuccugcg acaaggucuu cugccagccc uggcagcgcu gcaucgaggg caccugcguc      180

ugcaagcucc ccuaccagug ccccaagaac ggcaccgccg ucugcgccac caaccgccgc      240

uccuucccca ccuacugcca gcagaagucc cucgagugcc uccaccccgg caccaaguuc      300

cucaacaacg gcaccugcac cgccgagggc aaguucuccg ucucccucaa gcacggcaac      360

accgacuccg agggcaucgu cgaggucaag cucgucgacc aggacaagac cauguucauc      420

ugcaaguccu ccugguccau gcgcgaggcc aacgucgccu gccucgaccu cggcuuccag      480

cagggcgccg acacccagcg ccgcuucaag cucuccgacc ucuccaucaa cuccaccgag      540

ugccuccacg uccacugccg cggccucgag accucccucg ccgagugcac cuucaccaag      600

cgccgcacca ugggcuacca ggacuucgcc gacgucgucu gcuacaccca gaaggccgac      660

ucccccaugg acgacuucuu ccagugcguc aacggcaagu acaucuccca gaugaaggcc      720

ugcgacggca ucaacgacug cggcgaccag uccgacgagc ucugcugcaa ggccugccag      780

ggcaagggcu uccacugcaa guccggcguc ugcauccccu cccaguacca gugcaacggc      840

gaggucgacu gcaucaccgg cgaggacgag gucggcugcg ccggcuucgc cuccgucacc      900

caggaggaga ccgagauccu caccgccgac auggacgccg agcgccgccg caucaagucc      960

cuccucccca agcucuccug cggcgucaag aaccgcaugc acauccgccg caagcgcauc     1020

gucggcggca agcgcgccca gcucggcgac cuccccuggc aggucgccau caaggacgcc     1080

uccggcauca ccugcggcgg caucuacauc ggcggcugcu ggauccucac cgccgcccac     1140

ugccuccgcg ccuccaagac ccaccgcuac cagaucugga ccaccgucgu cgacuggauc     1200

caccccgacc ucaagcgcau cgucaucgag uacgucgacc gcaucaucuu ccacgagaac     1260

uacaacgccg gcaccuacca gaacgacauc gcccucaucg agaugaagaa ggacggcaac     1320

aagaaggacu gcgagcuccc ccgcuccauc cccgccugcg uccccugguc ccccuaccuc     1380

uuccagccca acgacaccug caucgucucc ggcuggggcc gcgagaagga caacgagcgc     1440

gucuucuccc uccagugggg cgaggucaag cucaucucca acugcuccaa guucuacggc     1500

aaccgcuucu acgagaagga gauggagugc gccggcaccu acgacggcuc caucgacgcc     1560

ugcaagggcg acuccggcgg cccccucguc ugcauggacg ccaacaacgu caccuacguc     1620

uggggcgucg ucuccugggg cgagaacugc ggcaagcccg aguuccccgg cgucuacacc     1680

aaggucgcca acuacuucga cuggaucucc uaccacgucg gccgccccuu caucucccag     1740

uacaacgucu ga                                                         1752


<210>  7846
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CFAI__Homo_sapiens__CCDS34049.1

<400>  7846
augaagcugc uccacguguu ccuucuguuu uugugcuucc auuuaagauu uuguaaaguc       60

accuacacaa gccaggagga ccugguugaa aagaaaugcc uagccaagaa auauacucac      120

cucuccugug auaagguguu cugccaaccc uggcagaggu guaucgaggg cacgugcgua      180

uguaagcugc cuuaccagug cccgaaaaac gggaccgcug ugugugcaac aaaucggcgc      240

ucuuuuccaa cuuauugcca gcaaaaguca cuugaauguc ugcaucccgg aaccaaauuc      300

uugaacaaug guacaugcac cgccgagggc aaguuuagug ucagccucaa acacgggaac      360

acugacuccg aaggaauugu ggagguuaag cugguggauc aggacaagac aauguucaua      420

ugcaaaucuu cguggucaau gcgagaggcg aaugucgcuu gucuggaucu cggcuuucag      480

cagggugccg acacccaacg uagauucaag uuaagcgauc ugaguaucaa cuccacggaa      540

ugccuucaug ugcacuguag gggguuggag acuucucugg cagaaugcac cuuuacaaaa      600

cggcgcacua ugggauacca ggacuucgcc gauguaguuu guuauaccca gaaggcugac      660

agcccuaugg augacuuuuu ccagugcgug aauggcaaau acauuuccca aaugaaggca      720

ugugauggca ucaacgacug cggggaccag ucagaugagc uauguugcaa agccugucag      780

ggaaaggguu uccacugcaa gaguggcguc ugcauuccaa gccaauauca guguaauggg      840

gagguggacu gcaucacagg agaagaugag gugggcugug cugguuuugc cucugucacc      900

caggaagaga cggaaauacu cacugcggac auggaugcag agagaaggcg gaucaaaucc      960

cugcuuccca agcugucaug cgggguuaaa aaccgcaugc auauucgaag aaagaggauc     1020

gugggaggca aacgggccca guugggcgac cucccuuggc aaguagcuau uaaggaugcc     1080

agcgggauca cauguggagg uauauacauu ggcgggugcu ggauccugac cgcagcucac     1140

uguuuacgug ccaguaagac ucaucgcuac cagauuugga caaccguggu cgacuggauc     1200

cacccagauc ugaaaagaau cgugauugag uauguugaca ggauaaucuu ccacgaaaau     1260

uacaacgcgg gaacguauca gaaugauauu gcccucaucg agaugaagaa agacggcaac     1320

aagaaagacu gcgaacuucc ccggucuaua ccugcaugug ugccaugguc cccguaccug     1380

uuucagccca augauaccug cauugucagc gguugggggc gagagaagga caacgaacgc     1440

guguucucgu ugcaaugggg cgagguaaag cuaaucucua acuguuccaa auuuuaugga     1500

aauagauucu acgagaagga aauggagugc gcuggcacau augauggguc aaucgacgcc     1560

ugcaaaggag auaguggugg cccucugguu uguauggacg cuaacaaugu gacuuacguc     1620

uggggagugg ucagcugggg cgaaaacugc gggaagccag aguuucccgg uguguacacc     1680

aaaguugcca auuauuucga uuggauuucc uaccaugugg ggaggccuuu uaucucucag     1740

uauaacguau ga                                                         1752


<210>  7847
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CFAI__Homo_sapiens__CCDS34049.1

<400>  7847
augaagcugc ugcacguguu ccugcuguuc cugugcuucc accugagauu cugcaaggug       60

accuacacca gccaggagga ccugguggag aagaagugcc uggccaagaa guacacccac      120

cugagcugcg acaagguguu cugccagccc uggcagagau gcaucgaggg caccugcgug      180

ugcaagcugc ccuaccagug ccccaagaac ggcaccgccg ugugcgccac caacagaaga      240

agcuucccca ccuacugcca gcagaagagc cuggagugcc ugcaccccgg caccaaguuc      300

cugaacaacg gcaccugcac cgccgagggc aaguucagcg ugagccugaa gcacggcaac      360

accgacagcg agggcaucgu ggaggugaag cugguggacc aggacaagac cauguucauc      420

ugcaagagca gcuggagcau gagagaggcc aacguggccu gccuggaccu gggcuuccag      480

cagggcgccg acacccagag aagauucaag cugagcgacc ugagcaucaa cagcaccgag      540

ugccugcacg ugcacugcag aggccuggag accagccugg ccgagugcac cuucaccaag      600

agaagaacca ugggcuacca ggacuucgcc gacguggugu gcuacaccca gaaggccgac      660

agccccaugg acgacuucuu ccagugcgug aacggcaagu acaucagcca gaugaaggcc      720

ugcgacggca ucaacgacug cggcgaccag agcgacgagc ugugcugcaa ggccugccag      780

ggcaagggcu uccacugcaa gagcggcgug ugcaucccca gccaguacca gugcaacggc      840

gagguggacu gcaucaccgg cgaggacgag gugggcugcg ccggcuucgc cagcgugacc      900

caggaggaga ccgagauccu gaccgccgac auggacgccg agagaagaag aaucaagagc      960

cugcugccca agcugagcug cggcgugaag aacagaaugc acaucagaag aaagagaauc     1020

gugggcggca agagagccca gcugggcgac cugcccuggc agguggccau caaggacgcc     1080

agcggcauca ccugcggcgg caucuacauc ggcggcugcu ggauccugac cgccgcccac     1140

ugccugagag ccagcaagac ccacagauac cagaucugga ccaccguggu ggacuggauc     1200

caccccgacc ugaagagaau cgugaucgag uacguggaca gaaucaucuu ccacgagaac     1260

uacaacgccg gcaccuacca gaacgacauc gcccugaucg agaugaagaa ggacggcaac     1320

aagaaggacu gcgagcugcc cagaagcauc cccgccugcg ugcccuggag ccccuaccug     1380

uuccagccca acgacaccug caucgugagc ggcuggggca gagagaagga caacgagaga     1440

guguucagcc ugcagugggg cgaggugaag cugaucagca acugcagcaa guucuacggc     1500

aacagauucu acgagaagga gauggagugc gccggcaccu acgacggcag caucgacgcc     1560

ugcaagggcg acagcggcgg cccccuggug ugcauggacg ccaacaacgu gaccuacgug     1620

uggggcgugg ugagcugggg cgagaacugc ggcaagcccg aguuccccgg cguguacacc     1680

aagguggcca acuacuucga cuggaucagc uaccacgugg gcagacccuu caucagccag     1740

uacaacgugu ga                                                         1752


<210>  7848
<211>  1752
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CFAI__Homo_sapiens__CCDS34049.1

<400>  7848
augaagcugc uccacguguu ccugcuuuuu cugugcuucc aucucagauu uuguaaaguc       60

accuacacaa gccaggagga ccugguugaa aagaaaugcc uugccaagaa auauacgcac      120

cuguccugug auaagguguu cugccaaccc uggcagcggu guaucgaggg gaccugcgug      180

uguaagcucc cuuaccagug cccgaaaaac gggacagcug ucugugccac caaucgcaga      240

ucuuuuccca cauauugcca gcaaaagagc cuggaauguc ugcauccugg aaccaaauuc      300

cucaacaaug gcacaugcac cgcggagggg aaguuuuccg ugucucugaa acacggaaac      360

acggacagcg aaggcauugu ugaggugaaa cuugucgauc aggacaagac cauguucauc      420

ugcaaguccu cuuggagcau gcgggaggcu aauguggccu gucuggaucu cggguuucag      480

cagggagccg acacacaacg cagauucaag cuguccgauc uuagcauuaa cucuaccgaa      540

ugccugcaug uucacugucg gggccucgag acaucccugg cugaaugcac cuuuacgaaa      600

cgcagaacaa ugggcuacca ggacuucgcc gauguggucu guuauaccca gaaggcugac      660

agccccaugg augacuuuuu ccagugcgug aaugggaaau acaucucuca aaugaaggcc      720

ugugauggaa uuaacgacug cggcgaccag uccgaugagc uguguugcaa agcgugucag      780

gggaagggau uccacugcaa gagcggcgug ugcaucccuu cucaauauca guguaauggg      840

gaggucgacu gcaucacagg agaagaugag guuggcugug ccggcuuugc uuccgugacc      900

caggaagaga ccgaaauucu cacagccgac auggaugcug agcggcgcag aaucaaaagc      960

cugcuuccca agcuguccug cggggugaaa aaccggaugc auauucgcag aaagcggauc     1020

gucggaggca aacgcgccca gcucggggac cugccuuggc aaguggcgau uaaggaugcc     1080

ucuggaauca cguguggcgg gauuuacauc ggaggcugcu ggauccuuac cgcugcccac     1140

ugucugagag cuagcaagac acaucgguac cagauuugga ccacaguugu ggacuggauc     1200

cacccggauc ucaaaagaau ugucaucgag uauguggacc gcauuaucuu ccacgaaaau     1260

uacaacgccg gcaccuauca gaaugauauc gcccugauug agaugaagaa agacgggaac     1320

aagaaagacu gcgaacugcc ccgguccauc ccugcuugug uucccuggag cccuuaccuc     1380

uuucagccca augauacgug cauugugucu ggauggggca gagagaagga caacgaacgc     1440

gucuucuccc ugcaaugggg cgaggugaaa cuuaucagca acuguucuaa guuuuaugga     1500

aaucgguucu acgagaagga aauggagugc gcgggcacau augaugggag cauugacgcc     1560

ugcaaaggcg auuccggagg cccgcugguc uguauggacg cuaacaaugu gaccuacguu     1620

uggggagugg ucucuugggg cgaaaacugc gggaagccug aguuucccgg gguguacacc     1680

aaaguugcca auuauuucga uuggaucagc uaccaugugg gaagaccuuu uaucucccag     1740

uauaacgucu ga                                                         1752


<210>  7849
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CH60__Homo_sapiens__NP_002147.2

<400>  7849

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  7850
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CH60__Homo_sapiens__NM_002156.4

<400>  7850
augcuucggu uacccacagu cuuucgccag augagaccgg uguccagggu acuggcuccu       60

caucucacuc gggcuuaugc caaagaugua aaauuuggug cagaugcccg agccuuaaug      120

cuucaaggug uagaccuuuu agccgaugcu guggccguua caauggggcc aaagggaaga      180

acagugauua uugagcagag uuggggaagu cccaaaguaa caaaagaugg ugugacuguu      240

gcaaagucaa uugacuuaaa agauaaauac aaaaacauug gagcuaaacu uguucaagau      300

guugccaaua acacaaauga agaagcuggg gauggcacua ccacugcuac uguacuggca      360

cgcucuauag ccaaggaagg cuucgagaag auuagcaaag gugcuaaucc aguggaaauc      420

aggagaggug ugauguuagc uguugaugcu guaauugcug aacuuaaaaa gcagucuaaa      480

ccugugacca ccccugaaga aauugcacag guugcuacga uuucugcaaa cggagacaaa      540

gaaauuggca auaucaucuc ugaugcaaug aaaaaaguug gaagaaaggg ugucaucaca      600

guaaaggaug gaaaaacacu gaaugaugaa uuagaaauua uugaaggcau gaaguuugau      660

cgaggcuaua uuucuccaua cuuuauuaau acaucaaaag gucagaaaug ugaauuccag      720

gaugccuaug uucuguugag ugaaaagaaa auuucuagua uccaguccau uguaccugcu      780

cuugaaauug ccaaugcuca ccguaagccu uuggucauaa ucgcugaaga uguugaugga      840

gaagcucuaa guacacucgu cuugaauagg cuaaagguug gucuucaggu uguggcaguc      900

aaggcuccag gguuugguga caauagaaag aaccagcuua aagauauggc uauugcuacu      960

gguggugcag uguuuggaga agagggauug acccugaauc uugaagacgu ucagccucau     1020

gacuuaggaa aaguuggaga ggucauugug accaaagacg augccaugcu cuuaaaagga     1080

aaaggugaca aggcucaaau ugaaaaacgu auucaagaaa ucauugagca guuagauguc     1140

acaacuagug aauaugaaaa ggaaaaacug aaugaacggc uugcaaaacu uucagaugga     1200

guggcugugc ugaagguugg ugggacaagu gauguugaag ugaaugaaaa gaaagacaga     1260

guuacagaug cccuuaaugc uacaagagcu gcuguugaag aaggcauugu uuugggaggg     1320

gguugugccc uccuucgaug cauuccagcc uuggacucau ugacuccagc uaaugaagau     1380

caaaaaauug guauagaaau uauuaaaaga acacucaaaa uuccagcaau gaccauugcu     1440

aagaaugcag guguugaagg aucuuugaua guugagaaaa uuaugcaaag uuccucagaa     1500

guugguuaug augcuauggc uggagauuuu gugaauaugg uggaaaaagg aaucauugac     1560

ccaacaaagg uugugagaac ugcuuuauug gaugcugcug guguggccuc ucuguuaacu     1620

acagcagaag uuguagucac agaaauuccu aaagaagaga aggacccugg aaugggugca     1680

auggguggaa ugggaggugg uaugggaggu ggcauguucu aa                        1722


<210>  7851
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CH60__Homo_sapiens__NM_002156.4

<400>  7851
augcugcgcc uccccaccgu guuccggcag augcgcccgg ucagccgggu gcuggcgccc       60

caccugaccc gcgccuacgc caaggacgug aaguucgggg ccgacgcccg ggcccucaug      120

cugcaggggg ucgaccugcu cgccgacgcg guggccguga cgaugggccc caaggggcgc      180

accgucauca ucgagcaguc cuggggcagc cccaagguga ccaaggacgg ggugaccguc      240

gccaagucca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggcgaaca acacgaacga ggaggccggc gacgggacca ccaccgccac gguccucgcc      360

cggagcaucg ccaaggaggg cuucgagaag aucuccaagg gggcgaaccc gguggagauc      420

cgccggggcg ugaugcuggc cgucgacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag gucgcgacca ucuccgccaa cggggacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gccgcaaggg ggugaucacg      600

gucaaggacg gcaagacccu caacgacgag cuggagauca ucgaggggau gaaguucgac      660

cggggcuaca ucucccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcucuc cgagaagaag aucagcucca uccagagcau cgugccggcc      780

cuggagaucg cgaacgccca ccgcaagccc cuggucauca ucgccgagga cguggacggg      840

gaggcccucu ccacccuggu ccugaaccgg cucaaggugg gccuccaggu ggucgccgug      900

aaggcgcccg gguucggcga caaccgcaag aaccagcuga aggacauggc caucgccacc      960

gggggcgccg uguucggcga ggaggggcug acgcugaacc uggaggacgu ccagccccac     1020

gaccucggca agguggggga ggugaucguc accaaggacg acgcgaugcu gcugaagggc     1080

aagggggaca aggcccagau cgagaagcgg auccaggaga ucaucgagca gcucgacgug     1140

accacgagcg aguacgagaa ggagaagcug aacgagcgcc uggccaagcu cuccgacggc     1200

guggccgucc ugaagguggg cgggaccagc gacguggagg ucaacgagaa gaaggaccgg     1260

gugaccgacg cccugaacgc gacccgcgcc gccguggagg agggcaucgu ccucgggggc     1320

gggugcgccc ugcugcggug caucccggcc cucgacuccc ugacgcccgc gaacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg gagccucauc guggagaaga ucaugcagag cuccagcgag     1500

gucggcuacg acgccauggc gggggacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg ucgugcggac ggcccugcug gacgccgccg gcguggcguc ccuccugacc     1620

accgccgagg ucguggugac cgagaucccg aaggaggaga aggaccccgg gaugggcgcc     1680

augggcggga ugggcggggg caugggcggc gggauguucu ga                        1722


<210>  7852
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CH60__Homo_sapiens__NM_002156.4

<400>  7852
augcuccgcc uccccaccgu cuuccgccag augcgccccg ucucccgcgu ccucgccccc       60

caccucaccc gcgccuacgc caaggacguc aaguucggcg ccgacgcccg cgcccucaug      120

cuccagggcg ucgaccuccu cgccgacgcc gucgccguca ccaugggccc caagggccgc      180

accgucauca ucgagcaguc cuggggcucc cccaagguca ccaaggacgg cgucaccguc      240

gccaagucca ucgaccucaa ggacaaguac aagaacaucg gcgccaagcu cguccaggac      300

gucgccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cguccucgcc      360

cgcuccaucg ccaaggaggg cuucgagaag aucuccaagg gcgccaaccc cgucgagauc      420

cgccgcggcg ucaugcucgc cgucgacgcc gucaucgccg agcucaagaa gcaguccaag      480

cccgucacca cccccgagga gaucgcccag gucgccacca ucuccgccaa cggcgacaag      540

gagaucggca acaucaucuc cgacgccaug aagaaggucg gccgcaaggg cgucaucacc      600

gucaaggacg gcaagacccu caacgacgag cucgagauca ucgagggcau gaaguucgac      660

cgcggcuaca ucucccccua cuucaucaac accuccaagg gccagaagug cgaguuccag      720

gacgccuacg uccuccucuc cgagaagaag aucuccucca uccaguccau cguccccgcc      780

cucgagaucg ccaacgccca ccgcaagccc cucgucauca ucgccgagga cgucgacggc      840

gaggcccucu ccacccucgu ccucaaccgc cucaaggucg gccuccaggu cgucgccguc      900

aaggcccccg gcuucggcga caaccgcaag aaccagcuca aggacauggc caucgccacc      960

ggcggcgccg ucuucggcga ggagggccuc acccucaacc ucgaggacgu ccagccccac     1020

gaccucggca aggucggcga ggucaucguc accaaggacg acgccaugcu ccucaagggc     1080

aagggcgaca aggcccagau cgagaagcgc auccaggaga ucaucgagca gcucgacguc     1140

accaccuccg aguacgagaa ggagaagcuc aacgagcgcc ucgccaagcu cuccgacggc     1200

gucgccgucc ucaaggucgg cggcaccucc gacgucgagg ucaacgagaa gaaggaccgc     1260

gucaccgacg cccucaacgc cacccgcgcc gccgucgagg agggcaucgu ccucggcggc     1320

ggcugcgccc uccuccgcug cauccccgcc cucgacuccc ucacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagcgc acccucaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcgucgaggg cucccucauc gucgagaaga ucaugcaguc cuccuccgag     1500

gucggcuacg acgccauggc cggcgacuuc gucaacaugg ucgagaaggg caucaucgac     1560

cccaccaagg ucguccgcac cgcccuccuc gacgccgccg gcgucgccuc ccuccucacc     1620

accgccgagg ucgucgucac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7853
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CH60__Homo_sapiens__NM_002156.4

<400>  7853
augcugagac uccccaccgu guucaggcag augcggccug ucagccgcgu ucuugcccca       60

caccugacac gagcuuacgc aaaggacgug aaauuuggcg ccgaugcgcg ugcuuugaug      120

uuacaagggg uagaccugcu agccgaugca guggccguca cuaugggacc gaaggguaga      180

acggugauca uugagcaguc cuggggcucu cccaaaguua ccaaggacgg ggugacaguc      240

gcuaaaucaa uagaucucaa ggacaaguau aaaaacaucg gagcaaagcu ggugcaggau      300

guagccaaua acacuaauga agaggcuggc gacgguacca caaccgccac uguucuugcg      360

aggaguauug caaaagaagg guucgagaag aucagcaaag gagccaaccc uguggaaauu      420

cggcgcggcg ucaugcuggc uguggaugcc gugaucgcag aguugaagaa gcaguccaaa      480

ccagucacaa cccccgagga aauagcucaa guugccacga ucucugcgaa uggcgacaag      540

gagauuggga acaucauuuc ggaugccaug aaaaaggugg gaagaaaagg uguaaucacu      600

gugaaggacg gcaaaacccu caaugaugaa cuggagauaa uugaggggau gaaguuugac      660

aggggauaca ucucaccuua uuucauuaac acaagcaagg gccagaaaug cgaauuucag      720

gacgcauacg uccugcucag ugagaagaaa aucuccucua uccagagcau ugugccagcu      780

uuagaaauag ccaaugcuca ucggaagccc cugguuauca uugccgagga uguggacggu      840

gaagcacuuu ccacuuuggu ccugaaccgc cuaaaagugg ggcuccaagu aguugccgug      900

aaggcuccug gauucggcga uaaucgaaag aaccagcuga aagacauggc gaucgcaacc      960

ggcggggccg ucuuuggaga ggagggucuu acacugaauu uggaagaugu gcagccacac     1020

gaccucggca aggucgggga ggugauaguu accaaagaug acgcuaugcu guuaaaggga     1080

aaaggcgaua aggcccagau ugaaaagaga auccaagaga ucauugaaca gcuggacgug     1140

acgacuucag aguaugagaa agaaaagcuc aacgagaggc uugcaaaacu gagugauggu     1200

guagccgucu ugaagguugg gggcacaagc gacguggaag ugaaugagaa aaaggaccgg     1260

gucaccgaug cucuaaacgc cacucgugca gcgguggaag agggaaucgu acugggcggg     1320

ggaugugcuc uccugcgcug cauuccggcc cuugacucuc ugacacccgc aaacgaggau     1380

cagaagauag guaucgaaau uaucaaaaga accuugaaga ucccugccau gacgauugcu     1440

aaaaaugccg gcguggaggg gucccucaua guugaaaaga ucaugcaauc aagcagugag     1500

gucggauacg acgcaauggc uggcgauuuc gugaacaugg uggagaaagg uauuaucgac     1560

ccaaccaagg ucguuaggac agcccuguua gaugcggccg ggguggcuuc ucugcuaacu     1620

accgcagaag ugguagucac agagauuccc aaagaagaga aggacccugg caugggagcc     1680

augggcggga ugggaggugg caugggaggg ggcauguuuu ga                        1722


<210>  7854
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CH60__Homo_sapiens__NM_002156.4

<400>  7854
augcugagac ugcccaccgu guucagacag augagacccg ugagcagagu gcuggccccc       60

caccugacca gagccuacgc caaggacgug aaguucggcg ccgacgccag agcccugaug      120

cugcagggcg uggaccugcu ggccgacgcc guggccguga ccaugggccc caagggcaga      180

accgugauca ucgagcagag cuggggcagc cccaagguga ccaaggacgg cgugaccgug      240

gccaagagca ucgaccugaa ggacaaguac aagaacaucg gcgccaagcu ggugcaggac      300

guggccaaca acaccaacga ggaggccggc gacggcacca ccaccgccac cgugcuggcc      360

agaagcaucg ccaaggaggg cuucgagaag aucagcaagg gcgccaaccc cguggagauc      420

agaagaggcg ugaugcuggc cguggacgcc gugaucgccg agcugaagaa gcagagcaag      480

cccgugacca cccccgagga gaucgcccag guggccacca ucagcgccaa cggcgacaag      540

gagaucggca acaucaucag cgacgccaug aagaaggugg gcagaaaggg cgugaucacc      600

gugaaggacg gcaagacccu gaacgacgag cuggagauca ucgagggcau gaaguucgac      660

agaggcuaca ucagccccua cuucaucaac accagcaagg gccagaagug cgaguuccag      720

gacgccuacg ugcugcugag cgagaagaag aucagcagca uccagagcau cgugcccgcc      780

cuggagaucg ccaacgccca cagaaagccc cuggugauca ucgccgagga cguggacggc      840

gaggcccuga gcacccuggu gcugaacaga cugaaggugg gccugcaggu gguggccgug      900

aaggcccccg gcuucggcga caacagaaag aaccagcuga aggacauggc caucgccacc      960

ggcggcgccg uguucggcga ggagggccug acccugaacc uggaggacgu gcagccccac     1020

gaccugggca aggugggcga ggugaucgug accaaggacg acgccaugcu gcugaagggc     1080

aagggcgaca aggcccagau cgagaagaga auccaggaga ucaucgagca gcuggacgug     1140

accaccagcg aguacgagaa ggagaagcug aacgagagac uggccaagcu gagcgacggc     1200

guggccgugc ugaagguggg cggcaccagc gacguggagg ugaacgagaa gaaggacaga     1260

gugaccgacg cccugaacgc caccagagcc gccguggagg agggcaucgu gcugggcggc     1320

ggcugcgccc ugcugagaug cauccccgcc cuggacagcc ugacccccgc caacgaggac     1380

cagaagaucg gcaucgagau caucaagaga acccugaaga uccccgccau gaccaucgcc     1440

aagaacgccg gcguggaggg cagccugauc guggagaaga ucaugcagag cagcagcgag     1500

gugggcuacg acgccauggc cggcgacuuc gugaacaugg uggagaaggg caucaucgac     1560

cccaccaagg uggugagaac cgcccugcug gacgccgccg gcguggccag ccugcugacc     1620

accgccgagg ugguggugac cgagaucccc aaggaggaga aggaccccgg caugggcgcc     1680

augggcggca ugggcggcgg caugggcggc ggcauguucu ga                        1722


<210>  7855
<211>  1722
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CH60__Homo_sapiens__NM_002156.4

<400>  7855
augcugagac uccccaccgu guuccggcag augcgcccug ucagcagagu ucuggccccg       60

caccuuacac gggcuuacgc caaggacgug aaauuuggcg cggaugcucg cgcccugaug      120

cuccaagggg uggaccugcu ugccgaugcu gucgccguga cgaugggacc caagggcaga      180

accguuauca uugagcaguc cugggggucu ccuaaaguga caaaggacgg agucaccgug      240

gcuaaaagca ucgaucugaa ggacaaguau aaaaacauug gcgccaagcu cguucaggau      300

guggcgaaua acacaaauga agaggccggg gacggaacca caaccgcuac gguccuggcc      360

cgguccaucg cuaaagaagg cuucgagaag auuucuaaag gcgccaaccc cguggaaauc      420

cgcagagggg ugaugcuggc ggucgaugcc guuaucgcug agcucaagaa gcagagcaaa      480

ccugugacca cacccgagga aauugcccaa guggcuacca ucuccgccaa uggagacaag      540

gagauuggca acaucauuuc ugaugccaug aaaaaggucg ggcggaaagg agugaucaca      600

guuaaggacg gcaaaacccu gaaugaugaa cuugagauua ucgaggggau gaaguuugac      660

cgcggauaca ucagcccuua uuucauuaac acguccaagg gccagaaaug cgaauuucag      720

gacgcuuacg ugcugcucag cgagaagaaa aucucuucca uucagagcau cgucccggcg      780

cuggaaauug ccaaugcuca uagaaagccc cuugugauca ucgccgagga uguugacggc      840

gaagcccugu cuacacucgu gcugaaccgg cugaaagucg ggcuccaagu ggucgcugug      900

aaggccccug gauucggcga uaaucgcaag aaccagcuga aagacauggc gauugcuacc      960

gggggagccg uuuuuggcga ggaggggcuu acacugaauc ucgaagaugu gcagccccac     1020

gaccugggaa aggucggcga ggugaucguu accaaagaug acgccaugcu ucugaagggc     1080

aaaggggaua aggcucagau ugaaaagaga auccaagaga uuaucgaaca gcucgacgug     1140

accacauccg aguaugagaa agaaaagcug aacgagcggc uggccaaacu cagcgaugga     1200

gucgcugugc ugaagguggg cgggacgucu gacguugaag ucaaugagaa aaaggaccgc     1260

gugaccgaug cccuuaacgc gacaagagcc gcuguggaag agggaaucgu ccugggcggg     1320

ggcugugccc uccugcggug cauuccugcu cuugacuccc ugacccccgc caacgaggau     1380

cagaagaucg gaauugaaau cauuaaaaga acacucaaga ucccggcgau gaccauugcc     1440

aaaaaugcug gcguggaggg gagccugauc guugaaaaga ucaugcaauc cucuagcgag     1500

gugggauacg acgccauggc uggcgauuuc gucaacaugg uggagaaagg gauuaucgac     1560

ccuacgaagg uugugcgcac agcccugcuc gaugccgcug gagucgcguc ccugcuuacc     1620

accgccgaag ugguugugac agagauuccc aaagaagaga aggacccugg caugggggcu     1680

augggcggaa ugggcggggg aaugggcggg ggaauguuuu ga                        1722


<210>  7856
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CIITA__Homo_sapiens__Q29704

<400>  7856

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Gly 
                325                 330                 335     


Arg Glu Val Pro Arg Lys Thr Gln Leu Gly Ser Ser Leu Leu Phe Gly 
            340                 345                 350         


Thr 
    


<210>  7857
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CIITA__Homo_sapiens__AAA92364

<400>  7857
augcguugcc uggcuccacg cccugcuggg uccuaccugu cagagcccca aggcagcuca       60

cagugugcca ccauggaguu ggggccccua gaagguggcu accuggagcu ucuuaacagc      120

gaugcugacc cccugugccu cuaccacuuc uaugaccaga uggaccuggc uggagaagaa      180

gagauugagc ucuacucaga acccgacaca gacaccauca acugcgacca guucagcagg      240

cuguugugug acauggaagg ugaugaagag accagggagg cuuaugccaa uaucgcggaa      300

cuggaccagu augucuucca ggacucccag cuggagggcc ugagcaagga cauuuucaag      360

cacauaggac cagaugaagu gaucggugag aguauggaga ugccagcaga aguugggcag      420

aaaagucaga aaagacccuu cccagaggag cuuccggcag accugaagca cuggaagcca      480

gcugagcccc ccacuguggu gacuggcagu cuccuagugg gaccagugag cgacugcucc      540

acccugcccu gccugccacu gccugcgcug uucaaccagg agccagccuc cggccagaug      600

cgccuggaga aaaccgacca gauucccaug ccuuucucca guuccucguu gagcugccug      660

aaucucccug agggacccau ccaguuuguc cccaccaucu ccacucugcc ccaugggcuc      720

uggcaaaucu cugaggcugg aacagggguc uccaguauau ucaucuacca uggugaggug      780

ccccaggcca gccaaguacc cccucccagu ggauucacug uccacggccu cccaacaucu      840

ccagaccggc caggcuccac cagccccuuc gcuccaucag ccacugaccu gcccagcaug      900

ccugaaccug cccugaccuc ccgagcaaac augacagagc acaagacguc ccccacccaa      960

ugcccggcag cuggagaggu cuccaacaag cuuccaaaau ggccuggacg agaaguuccu     1020

cggaagacac agcuggggag cucccugcug uucgggaccu aa                        1062


<210>  7858
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CIITA__Homo_sapiens__AAA92364

<400>  7858
augcgcugcc uggcgccccg gccggccggc agcuaccucu ccgagcccca ggggagcucc       60

cagugcgcca ccauggagcu gggcccccug gagggcgggu accucgagcu gcugaacagc      120

gacgccgacc cccucugccu guaccacuuc uacgaccaga uggaccuggc cggggaggag      180

gagaucgagc ucuacuccga gccggacacc gacacgauca acugcgacca guucagccgc      240

cugcugugcg acauggaggg cgacgaggag acccgggagg ccuacgccaa caucgcggag      300

cucgaccagu acguguucca ggacucccag cuggagggcc ugagcaagga caucuucaag      360

cacaucgggc ccgacgaggu caucggcgag uccauggaga ugcccgccga gguggggcag      420

aagucccaga agcgccccuu cccggaggag cuccccgccg accugaagca cuggaagccc      480

gccgagcccc cgaccguggu caccggcagc cugcucgugg ggcccgugag cgacugcucc      540

acgcugcccu gccugccccu cccggcgcug uucaaccagg agcccgccag cggccagaug      600

cggcuggaga agaccgacca gauccccaug cccuucucca gcuccagccu cuccugccug      660

aaccugccgg agggccccau ccaguucguc cccaccauca gcacccuccc ccacgggcug      720

uggcagauca gcgaggccgg cacgggggug uccagcaucu ucaucuacca cggcgaggug      780

ccgcaggccu cccagguccc gccgcccagc ggcuucaccg ugcacgggcu gcccaccucc      840

cccgaccgcc ccggcagcac cucccccuuc gcccccagcg cgacggaccu ccccuccaug      900

cccgagccgg cccugaccag ccgggccaac augaccgagc acaagaccuc ccccacgcag      960

ugccccgccg ccggggaggu gagcaacaag cugcccaagu ggccgggccg cgaggucccc     1020

cggaagaccc agcucggguc cagccugcug uucggcaccu ga                        1062


<210>  7859
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CIITA__Homo_sapiens__AAA92364

<400>  7859
augcgcugcc ucgccccccg ccccgccggc uccuaccucu ccgagcccca gggcuccucc       60

cagugcgcca ccauggagcu cggcccccuc gagggcggcu accucgagcu ccucaacucc      120

gacgccgacc cccucugccu cuaccacuuc uacgaccaga uggaccucgc cggcgaggag      180

gagaucgagc ucuacuccga gcccgacacc gacaccauca acugcgacca guucucccgc      240

cuccucugcg acauggaggg cgacgaggag acccgcgagg ccuacgccaa caucgccgag      300

cucgaccagu acgucuucca ggacucccag cucgagggcc ucuccaagga caucuucaag      360

cacaucggcc ccgacgaggu caucggcgag uccauggaga ugcccgccga ggucggccag      420

aagucccaga agcgccccuu ccccgaggag cuccccgccg accucaagca cuggaagccc      480

gccgagcccc ccaccgucgu caccggcucc cuccucgucg gccccgucuc cgacugcucc      540

acccuccccu gccucccccu ccccgcccuc uucaaccagg agcccgccuc cggccagaug      600

cgccucgaga agaccgacca gauccccaug cccuucuccu ccuccucccu cuccugccuc      660

aaccuccccg agggccccau ccaguucguc cccaccaucu ccacccuccc ccacggccuc      720

uggcagaucu ccgaggccgg caccggcguc uccuccaucu ucaucuacca cggcgagguc      780

ccccaggccu cccagguccc cccccccucc ggcuucaccg uccacggccu ccccaccucc      840

cccgaccgcc ccggcuccac cucccccuuc gcccccuccg ccaccgaccu ccccuccaug      900

cccgagcccg cccucaccuc ccgcgccaac augaccgagc acaagaccuc ccccacccag      960

ugccccgccg ccggcgaggu cuccaacaag cuccccaagu ggcccggccg cgaggucccc     1020

cgcaagaccc agcucggcuc cucccuccuc uucggcaccu ga                        1062


<210>  7860
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CIITA__Homo_sapiens__AAA92364

<400>  7860
augagaugcc uggcccccag gccugcuggc agcuaccucu ccgagccaca ggggucuuca       60

caaugugcaa ccauggaacu uggaccgcug gaggguggcu auuuggaauu acugaacagu      120

gacgccgauc cccuaugccu cuaccacuuc uaugaccaga uggaucuggc gggggaggaa      180

gagaucgagc uuuacagcga accugacaca gauacuauua auugugacca guuuucccgg      240

cuguugugcg auauggaggg agacgaagag acgcgcgagg cuuaugccaa cauagcagaa      300

cucgaucagu acguguucca agacucucag cuggagggcc ugucgaagga uaucuuuaaa      360

cauauugguc cagacgaagu caucggggag ucaauggaaa ugcccgccga gguuggacaa      420

aagagccaga aacgaccuuu cccagaggaa cuccccgcug auuuaaagca cuggaaaccu      480

gcagagccac cgaccguggu aacaggcagu cugcuugugg gccccgucuc cgacuguucu      540

acuuugccuu gccugccacu acccgcccuc uuuaaucagg aaccugcuag cgggcagaug      600

cgucuggaga agaccgacca gauuccaaug cccuucuccu caaguagccu uucuugucug      660

aacuugccgg aaggaccuau ccaguuugug cccacaauau ccacccuccc acauggucug      720

uggcaaaucu cagaggccgg cacugggguu agcaguauuu ucaucuauca cggagaggug      780

ccucaggcgu cucaggugcc cccacccucc ggcuuuacag uccaugguuu accuaccagc      840

ccagauagac cggggucgac gucucccuuc gcaccuuccg ccacugaccu gccaucaaug      900

cccgaaccug cucucaccag uagggccaau augacagagc acaagacuag cccaacccaa      960

ugccccgcag cuggagaagu auccaacaaa cuuccgaagu ggccuggccg ggagguucca     1020

cgcaaaacac agcugggcuc uagcuugcua uuugggaccu ga                        1062


<210>  7861
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CIITA__Homo_sapiens__AAA92364

<400>  7861
augagaugcc uggcccccag acccgccggc agcuaccuga gcgagcccca gggcagcagc       60

cagugcgcca ccauggagcu gggcccccug gagggcggcu accuggagcu gcugaacagc      120

gacgccgacc cccugugccu guaccacuuc uacgaccaga uggaccuggc cggcgaggag      180

gagaucgagc uguacagcga gcccgacacc gacaccauca acugcgacca guucagcaga      240

cugcugugcg acauggaggg cgacgaggag accagagagg ccuacgccaa caucgccgag      300

cuggaccagu acguguucca ggacagccag cuggagggcc ugagcaagga caucuucaag      360

cacaucggcc ccgacgaggu gaucggcgag agcauggaga ugcccgccga ggugggccag      420

aagagccaga agagacccuu ccccgaggag cugcccgccg accugaagca cuggaagccc      480

gccgagcccc ccaccguggu gaccggcagc cugcuggugg gccccgugag cgacugcagc      540

acccugcccu gccugccccu gcccgcccug uucaaccagg agcccgccag cggccagaug      600

agacuggaga agaccgacca gauccccaug cccuucagca gcagcagccu gagcugccug      660

aaccugcccg agggccccau ccaguucgug cccaccauca gcacccugcc ccacggccug      720

uggcagauca gcgaggccgg caccggcgug agcagcaucu ucaucuacca cggcgaggug      780

ccccaggcca gccaggugcc cccccccagc ggcuucaccg ugcacggccu gcccaccagc      840

cccgacagac ccggcagcac cagccccuuc gcccccagcg ccaccgaccu gcccagcaug      900

cccgagcccg cccugaccag cagagccaac augaccgagc acaagaccag ccccacccag      960

ugccccgccg ccggcgaggu gagcaacaag cugcccaagu ggcccggcag agaggugccc     1020

agaaagaccc agcugggcag cagccugcug uucggcaccu ga                        1062


<210>  7862
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CIITA__Homo_sapiens__AAA92364

<400>  7862
augagaugcc uggcuccccg gccugccggc agcuaccucu ccgagccgca ggggucuagc       60

caaugugcca ccauggaacu gggaccccuu gagggcgggu aucuggaacu ccugaacucc      120

gacgcggauc cucuuugccu guaccacuuc uaugaccaga uggaucucgc uggagaggaa      180

gagaucgagc uguacucuga acccgacaca gauacgauua auugugacca guuuagccgc      240

cugcucugcg auauggaggg cgacgaagag accagagagg ccuaugccaa caucgcugaa      300

cuggaucagu acguguucca agacucccag cuugaggggc ugucuaagga uauuuuuaaa      360

cauaucggac cugacgaagu cauuggcgag agcauggaaa ugcccgccga gguuggccag      420

aagucccaga aacggccuuu cccggaggaa cuccccgcug aucugaagca cuggaaaccu      480

gccgagcccc cuacaguggu gaccgggagc cuucuggucg gacccguguc ugacuguucc      540

acacucccgu gccugccucu gcccgcgcuc uuuaaucaag aaccugccag cggccagaug      600

cgccuggaga agaccgacca gauccccaug cccuucucuu ccagcucucu uuccugucug      660

aaccucccug aagggccgau ccaguuuguu cccacaauua gcacccugcc ucauggacuu      720

uggcaaaucu ccgaggcugg cacgggggug ucuagcauuu ucaucuauca cggagagguc      780

ccccaggccu cccaggugcc ucccccgagc ggcuuuaccg uucauggccu gccuacaucu      840

cccgauagac cuggguccac cagccccuuc gcuccuucug ccacagaccu ccccagcaug      900

ccggaaccug cgcugaccuc ccgggccaau augacggagc acaagacauc ucccacccaa      960

ugccccgcug ccggagaagu gagcaacaaa cugccuaagu ggccgggccg cgaggucccc     1020

agaaaaacac agcucggguc cagccugcuu uuuggaaccu ga                        1062


<210>  7863
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B3KN68

<400>  7863

Met Ser Ala Ser Ala Val Phe Ile Leu Asp Val Lys Gly Lys Pro Leu 
1               5                   10                  15      


Ile Ser Arg Asn Tyr Lys Gly Asp Val Ala Met Ser Lys Ile Glu His 
            20                  25                  30          


Phe Met Pro Leu Leu Val Gln Arg Glu Glu Glu Gly Ala Leu Ala Pro 
        35                  40                  45              


Leu Leu Ser His Gly Gln Val His Phe Leu Trp Thr Lys His Ser Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Thr Ser Lys Asn Ala Asn Ala Ser Leu Val 
65                  70                  75                  80  


Tyr Ser Phe Leu Tyr Lys Thr Ile Glu Val Phe Cys Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Val Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Phe Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Gln Ser Asn Lys Leu Glu Thr 
    130                 135                 140                 


Gly Lys Ser Arg Val Pro Pro Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Lys Lys Asn Glu Val Phe Ile Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Val Asn Ala Asn Gly Ser Val Leu Leu Ser 
            180                 185                 190         


Glu Ile Val Gly Thr Ile Lys Leu Lys Val Phe Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Leu Arg Leu Gly Leu Asn Asp Arg Val Leu Phe Glu Leu Thr Gly 
    210                 215                 220                 


Arg Ser Lys Asn Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln 
225                 230                 235                 240 


Cys Val Arg Leu Ser Arg Phe Asp Asn Asp Arg Thr Ile Ser Phe Ile 
                245                 250                 255     


Pro Pro Asp Gly Asp Phe Glu Leu Met Ser Tyr Arg Leu Ser Thr Gln 
            260                 265                 270         


Val Lys Pro Leu Ile Trp Ile Glu Ser Val Ile Glu Lys Phe Ser His 
        275                 280                 285             


Ser Arg Val Glu Ile Thr Val Lys Ala Lys Gly Gln Phe Lys Lys Gln 
    290                 295                 300                 


Ser Val Ala Asn Gly Val Glu Ile Ser Val Pro Val Pro Ser Asp Ala 
305                 310                 315                 320 


Asp Ser Pro Arg Phe Lys Thr Ser Val Gly Ser Ala Lys Tyr Val Pro 
                325                 330                 335     


Glu Arg Asn Val Val Ile Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys 
            340                 345                 350         


Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Lys Glu 
        355                 360                 365             


Glu Val Glu Gly Arg Pro Pro Ile Gly Val Lys Phe Glu Ile Pro Tyr 
    370                 375                 380                 


Phe Thr Val Ser Gly Ile Gln Val Arg Tyr Met Lys Ile Ile Glu Lys 
385                 390                 395                 400 


Ser Gly Tyr Gln Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Ser Gly 
                405                 410                 415     


Asp Tyr Gln Leu Arg Thr Ser 
            420             


<210>  7864
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG51230

<400>  7864
auguccgccu cggcugucuu cauucuggac guuaagggca agccauugau cagccgcaac       60

uacaagggcg auguggccau gagcaagauu gagcacuuca ugccuuugcu gguacagcgg      120

gaggaggaag gcgcccuggc cccgcugcug agccacggcc agguccacuu ccuauggacc      180

aaacacagca accucuacuu gguggccacc acaucgaaga augccaaugc cucccuggug      240

uacuccuucc uguauaagac aauagaggua uucugcgaau acuucaagga gcuggaggag      300

gagagcaucc gggacaacuu ugucaucguc uacgaguugc uggacgagcu cauggacuuu      360

ggcuucccgc agaccaccga cagcaagauc cugcaggagu acaucacuca gcagagcaac      420

aagcuggaga cgggcaaguc acgggugcca cccacuguca ccaacgcugu guccuggcgc      480

uccgagggua ucaaguauaa gaagaacgag gucuucauug augucauaga gucugucaac      540

cugcugguca augccaacgg cagcguccuu cugagcgaaa ucgucgguac caucaagcuc      600

aagguguuuc ugucgggaau gccagagcug cggcugggcc ucaaugaccg cgugcucuuc      660

gagcucacug gccgcagcaa gaacaaauca guagagcugg aggauguaaa auuccaccag      720

ugcgugcggc ucucucgcuu ugacaacgac cgcaccaucu ccuucauccc gccugauggu      780

gacuuugagc ucaugucaua ccgccucagc acccagguca agccacugau cuggauugag      840

ucugucauug agaaguucuc ccacagccgc guggagauca cggucaaggc caaggggcag      900

uuuaagaaac agucaguggc caacggugug gagauaucug ugccuguacc cagcgaugcc      960

gacuccccca gauucaagac cagugugggc agcgccaagu augugccgga gagaaacguc     1020

gugauuugga guauuaaguc uuucccgggg ggcaaggagu acuugaugcg agcccacuuu     1080

ggccucccca guguggaaaa ggaagaggug gagggccggc cccccaucgg ggucaaguuu     1140

gagauccccu acuucaccgu cucugggauc cagguccgau acaugaagau cauugagaaa     1200

agugguuacc aggcccugcc cuggguucgc uacaucaccc agagugguga uuaccaacuu     1260

cguaccagcu ag                                                         1272


<210>  7865
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG51230

<400>  7865
augagcgccu ccgccguguu cauccuggac gucaagggca agccccucau cagccgcaac       60

uacaaggggg acguggcgau guccaagauc gagcacuuca ugccgcugcu ggugcagcgg      120

gaggaggagg gcgcccucgc gccccugcug agccacgggc agguccacuu ccucuggacc      180

aagcacucca accuguaccu gguggccacc acgagcaaga acgccaacgc cucccucgug      240

uacagcuucc uguacaagac caucgagguc uucugcgagu acuucaagga gcuggaggag      300

gaguccaucc gcgacaacuu cgugaucgug uacgagcucc uggacgagcu gauggacuuc      360

ggcuuccccc agaccaccga cagcaagauc cuccaggagu acaucacgca gcaguccaac      420

aagcuggaga ccggcaagag ccgggugccc ccgaccguca ccaacgccgu guccuggcgc      480

agcgagggga ucaaguacaa gaagaacgag gucuucaucg acgugaucga guccgugaac      540

cugcucguca acgccaacgg cagcgugcug cuguccgaga ucguggggac gaucaagcuc      600

aaggucuucc ugagcggcau gcccgagcug cggcucgggc ugaacgaccg cgugcuguuc      660

gagcucaccg gccgguccaa gaacaagagc guggagcugg aggacgucaa guuccaccag      720

ugcgugcgcc ugagccgguu cgacaacgac cgcaccaucu ccuucauccc gcccgacggg      780

gacuucgagc ucaugagcua ccggcugucc acccagguga agccccugau cuggaucgag      840

agcgucaucg agaaguucuc ccacagccgc guggagauca cggucaaggc caagggccag      900

uucaagaagc aguccguggc gaacggcgug gagaucagcg uccccgugcc cuccgacgcc      960

gacagccccc gguucaagac cuccgugggg agcgccaagu acgucccgga gcgcaacgug     1020

gugaucuggu ccaucaagag cuuccccggc gggaaggagu accucaugcg ggcccacuuc     1080

ggccugcccu ccgucgagaa ggaggaggug gagggccggc ccccgaucgg ggugaaguuc     1140

gagauccccu acuucaccgu cagcggcauc caggugcgcu acaugaagau caucgagaag     1200

uccggguacc aggcccugcc cugggugcgc uacaucaccc agagcggcga cuaccagcuc     1260

cggacguccu ga                                                         1272


<210>  7866
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG51230

<400>  7866
auguccgccu ccgccgucuu cauccucgac gucaagggca agccccucau cucccgcaac       60

uacaagggcg acgucgccau guccaagauc gagcacuuca ugccccuccu cguccagcgc      120

gaggaggagg gcgcccucgc cccccuccuc ucccacggcc agguccacuu ccucuggacc      180

aagcacucca accucuaccu cgucgccacc accuccaaga acgccaacgc cucccucguc      240

uacuccuucc ucuacaagac caucgagguc uucugcgagu acuucaagga gcucgaggag      300

gaguccaucc gcgacaacuu cgucaucguc uacgagcucc ucgacgagcu cauggacuuc      360

ggcuuccccc agaccaccga cuccaagauc cuccaggagu acaucaccca gcaguccaac      420

aagcucgaga ccggcaaguc ccgcgucccc cccaccguca ccaacgccgu cuccuggcgc      480

uccgagggca ucaaguacaa gaagaacgag gucuucaucg acgucaucga guccgucaac      540

cuccucguca acgccaacgg cuccguccuc cucuccgaga ucgucggcac caucaagcuc      600

aaggucuucc ucuccggcau gcccgagcuc cgccucggcc ucaacgaccg cguccucuuc      660

gagcucaccg gccgcuccaa gaacaagucc gucgagcucg aggacgucaa guuccaccag      720

ugcguccgcc ucucccgcuu cgacaacgac cgcaccaucu ccuucauccc ccccgacggc      780

gacuucgagc ucauguccua ccgccucucc acccagguca agccccucau cuggaucgag      840

uccgucaucg agaaguucuc ccacucccgc gucgagauca ccgucaaggc caagggccag      900

uucaagaagc aguccgucgc caacggcguc gagaucuccg uccccguccc cuccgacgcc      960

gacucccccc gcuucaagac cuccgucggc uccgccaagu acguccccga gcgcaacguc     1020

gucaucuggu ccaucaaguc cuuccccggc ggcaaggagu accucaugcg cgcccacuuc     1080

ggccuccccu ccgucgagaa ggaggagguc gagggccgcc cccccaucgg cgucaaguuc     1140

gagauccccu acuucaccgu cuccggcauc cagguccgcu acaugaagau caucgagaag     1200

uccggcuacc aggcccuccc cuggguccgc uacaucaccc aguccggcga cuaccagcuc     1260

cgcaccuccu ga                                                         1272


<210>  7867
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG51230

<400>  7867
augagcgccu ccgcuguguu cauccuggac gucaagggca aaccccucau uucuagaaac       60

uacaaggggg auguugcaau gucaaaaaua gagcacuuua ugccucuucu ggugcagagg      120

gaagaggaag gagccuuggc gccauuacug agucaugguc aaguacacuu ccuauggacc      180

aagcauagca aucucuaucu gguggcuaca acuuccaaaa acgccaaugc aucucuuguc      240

uacucguuuc uguauaagac gaucgaggug uucugcgaau acuuuaagga guuggaggaa      300

gagucaauuc gggacaacuu cguuaucgug uaugaacucc uggaugagcu gauggacuuu      360

ggcuucccgc agaccacaga uagcaaaauu cuccaggagu acaucacuca gcaaaguaau      420

aaguuagaaa ccgggaaauc ccgcgugccc ccuacaguga ccaacgccgu aucuuggcga      480

agcgagggaa uaaaguauaa aaagaaugaa guuuuuaucg acgugauuga guccgucaac      540

cugcuuguga augcuaacgg cucaguguug cugagugaaa ucgucgguac uauuaagcua      600

aaaguuuucc ucagcgggau gccagagcug cgucuuggac ugaaugauag aguguuguuu      660

gagcucacag gcaggucuaa gaacaaaucc guagaacugg aggacgugaa guuccaccag      720

uguguccggu uaucacgcuu ugauaaugac agaaccauca gcuucauacc cccugauggc      780

gacuucgaac ugaugaguua caggcucucu acgcagguca aaccacuuau uuggaucgag      840

uccguuauug aaaaguuuag ccauucgcgg guggagauca cugucaaagc aaaggggcag      900

uucaagaaac aaucuguggc caacggagua gagaucuccg uucccgugcc uucagaugcu      960

gacaguccac gcuuuaagac cagcgucggu uccgccaaau acgugccgga acgaaauguc     1020

gugauuuggu cuauaaagag cuuccccggc gggaaagagu aucugaugag agcgcacuuu     1080

ggauugccuu caguugaaaa ggaggaagug gagggcaggc cacccaucgg uguaaaguuc     1140

gagauuccuu acuuuacagu cagugggauc caggugcggu auaugaaaau aauugaaaag     1200

uccggauacc aggcacuacc auggguucgu uauaucacuc agagcggcga cuaccaacug     1260

cgcaccucuu ga                                                         1272


<210>  7868
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG51230

<400>  7868
augagcgcca gcgccguguu cauccuggac gugaagggca agccccugau cagcagaaac       60

uacaagggcg acguggccau gagcaagauc gagcacuuca ugccccugcu ggugcagaga      120

gaggaggagg gcgcccuggc cccccugcug agccacggcc aggugcacuu ccuguggacc      180

aagcacagca accuguaccu gguggccacc accagcaaga acgccaacgc cagccuggug      240

uacagcuucc uguacaagac caucgaggug uucugcgagu acuucaagga gcuggaggag      300

gagagcauca gagacaacuu cgugaucgug uacgagcugc uggacgagcu gauggacuuc      360

ggcuuccccc agaccaccga cagcaagauc cugcaggagu acaucaccca gcagagcaac      420

aagcuggaga ccggcaagag cagagugccc cccaccguga ccaacgccgu gagcuggaga      480

agcgagggca ucaaguacaa gaagaacgag guguucaucg acgugaucga gagcgugaac      540

cugcugguga acgccaacgg cagcgugcug cugagcgaga ucgugggcac caucaagcug      600

aagguguucc ugagcggcau gcccgagcug agacugggcc ugaacgacag agugcuguuc      660

gagcugaccg gcagaagcaa gaacaagagc guggagcugg aggacgugaa guuccaccag      720

ugcgugagac ugagcagauu cgacaacgac agaaccauca gcuucauccc ccccgacggc      780

gacuucgagc ugaugagcua cagacugagc acccagguga agccccugau cuggaucgag      840

agcgugaucg agaaguucag ccacagcaga guggagauca ccgugaaggc caagggccag      900

uucaagaagc agagcguggc caacggcgug gagaucagcg ugcccgugcc cagcgacgcc      960

gacagcccca gauucaagac cagcgugggc agcgccaagu acgugcccga gagaaacgug     1020

gugaucugga gcaucaagag cuuccccggc ggcaaggagu accugaugag agcccacuuc     1080

ggccugccca gcguggagaa ggaggaggug gagggcagac cccccaucgg cgugaaguuc     1140

gagauccccu acuucaccgu gagcggcauc caggugagau acaugaagau caucgagaag     1200

agcggcuacc aggcccugcc cugggugaga uacaucaccc agagcggcga cuaccagcug     1260

agaaccagcu ga                                                         1272


<210>  7869
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG51230

<400>  7869
augagcgcuu ccgcuguguu cauccuggac gucaagggca aaccccucau uucuagaaac       60

uacaaggggg auguugccau gagcaaaauc gagcacuuua ugccucugcu ugugcagcgg      120

gaagaggaag gagcgcuggc uccgcuccug ucccauggcc aagugcacuu ccuuuggacc      180

aagcauucua aucuguaucu cgucgccaca acgagcaaaa acgccaaugc uucccuggug      240

uacucuuuuc uguauaagac cauugagguu uucugcgaau acuuuaagga gcucgaggaa      300

gagagcaucc gcgacaacuu cgugauuguc uaugaacugc uugaugagcu gauggacuuu      360

ggguuccccc agacaaccga uuccaaaauc cuccaggagu acaucacaca gcaaagcaau      420

aagcuggaaa ccggaaaauc uagagugccu cccacaguua ccaacgccgu guccuggcgg      480

agcgagggca uuaaguauaa aaagaaugaa gucuuuaucg acgugauuga gucugugaac      540

cuucugguca augcuaacgg guccguucuc cugagcgaaa ucgugggaac gauuaagcug      600

aaaguguucc ucucuggcau gccugagcug cgccuuggcc ugaaugauag aguccucuuu      660

gagcugaccg ggcgguccaa gaacaaaagc guggaacuug aggacguuaa guuccaccag      720

ugugugcgcc uguccagauu ugauaaugac cggacaaucu cuuucauucc cccugaugga      780

gacuucgaac ucaugagcua ccgccugucc acccagguca aaccgcugau cuggaucgag      840

agcgugauug aaaaguuuuc ucauuccaga guugagauca cagugaaagc caagggccag      900

uucaagaaac aaagcgucgc gaacggggug gagauuucug uccccgugcc uagcgaugcc      960

gacucucccc gguuuaagac cuccguugga agcgcuaaau acgugccuga acgcaauguc     1020

gugaucuggu ccauuaagag cuuccccggc gggaaagagu aucucaugag agcccacuuu     1080

ggacugccgu cuguugaaaa ggaggaagug gagggccggc cucccaucgg cgucaaguuc     1140

gagaucccuu acuuuacggu guccgggauu caggugcgcu auaugaaaau cauugaaaag     1200

agcggauacc aggcccuucc cuggguuaga uauaucacac agucuggcga cuaccaacug     1260

cggaccuccu ga                                                         1272


<210>  7870
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B3KNW1

<400>  7870

Met Arg Ser Ala Leu Leu Glu Arg Met Pro Val Met Glu Lys Val Thr 
1               5                   10                  15      


Thr Asn Gly Pro Thr Glu Ile Val Gln Thr Asn Gly Glu Thr Glu Pro 
            20                  25                  30          


Ala Pro Leu Glu Thr Lys Pro Pro Pro Ser Gly Pro Gln Pro Thr Ser 
        35                  40                  45              


Gln Ala Asn Asp Leu Leu Asp Leu Leu Gly Gly Asn Asp Ile Thr Pro 
    50                  55                  60                  


Val Ile Pro Thr Ala Pro Thr Ser Lys Pro Ser Ser Ala Gly Gly Glu 
65                  70                  75                  80  


Leu Leu Asp Leu Leu Gly Asp Ile Asn Leu Thr Gly Ala Pro Ala Ala 
                85                  90                  95      


Ala Pro Ala Pro Ala Ser Val Pro Gln Ile Ser Gln Pro Pro Phe Leu 
            100                 105                 110         


Leu Asp Gly Leu Ser Ser Gln Pro Leu Phe Asn Asp Ile Ala Ala Gly 
        115                 120                 125             


Ile Pro Ser Ile Thr Ala Tyr Ser Lys Asn Gly Leu Lys Ile Glu Phe 
    130                 135                 140                 


Thr Phe Glu Arg Ser Asn Thr Asn Pro Ser Val Thr Val Ile Thr Ile 
145                 150                 155                 160 


Gln Ala Ser Asn Ser Thr Glu Leu Asp Met Thr Asp Phe Val Phe Gln 
                165                 170                 175     


Ala Ala Val Pro Lys Thr Phe Gln Leu Gln Leu Leu Ser Pro Ser Ser 
            180                 185                 190         


Ser Ile Val Pro Ala Phe Asn Thr Gly Thr Ile Thr Gln Val Ile Lys 
        195                 200                 205             


Val Leu Asn Pro Gln Lys Gln Gln Leu Arg Met Arg Ile Lys Leu Thr 
    210                 215                 220                 


Tyr Asn His Lys Gly Ser Ala Met Gln Asp Leu Ala Glu Val Asn Asn 
225                 230                 235                 240 


Phe Pro Pro Gln Ser Trp Gln 
                245         


<210>  7871
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG51473

<400>  7871
augaggucug cccuacuuga gagaaugccu gucauggaaa aagugaccac aaauggcccu       60

acugagauug ugcagacaaa uggagagaca gaaccagcuc cacuagagac caaaccgcca      120

cccucugggc cacagcccac cagccaggcc aaugauuuau uggauuuguu gggaggaaau      180

gacauaacac cuguuauucc aacugcgccu acaagcaaac caucuucugc ugguggagaa      240

cuucuugauu ugcugggaga caucaaccuu acaggugcuc cagcugcugc ucccgccccu      300

gccucagucc cacagauauc ccagcccccc uucuuguugg augggcuuuc aucacagccu      360

cucuucaaug auauugcugc aggcaucccc uccaucacag cauacaguaa gaauggcuug      420

aagauagaau ucaccuuuga acggucaaau accaacccca guguaacagu gauaacgaua      480

caggccucca acagcacaga gcuagauaug acggacuuug uuuuccaagc ugcaguacca      540

aagacauucc agcugcagcu cuugucuccu agcagcagca uugucccagc auuuaacacg      600

gggaccauca cacaagucau uaaaguucug aacccucaga agcaacagcu gcgaaugcgg      660

aucaagcuua cauauaauca caagggcuca gcaaugcaag aucuagcaga ggugaacaac      720

uuucccccuc aguccuggca auga                                             744


<210>  7872
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG51473

<400>  7872
augcgcagcg cccugcucga gcggaugccc gugauggaga aggucaccac caacggcccc       60

acggagaucg ugcagaccaa cggggagacc gagcccgcgc cccuggagac caagcccccg      120

cccuccggcc cccagcccac gagccaggcc aacgaccugc ucgaccugcu cgggggcaac      180

gacaucaccc cggugauccc caccgccccc accuccaagc ccagcuccgc cgggggcgag      240

cugcuggacc ugcucggcga caucaaccug acgggggccc cggccgcggc ccccgccccc      300

gccagcgucc cccagaucuc ccagccgccc uuccugcucg acggccugag cucccagccc      360

cuguucaacg acaucgcggc cgggaucccc agcaucaccg ccuacuccaa gaacggccuc      420

aagaucgagu ucaccuucga gcgcagcaac accaacccgu ccgugacggu gaucaccauc      480

caggccagca acuccaccga gcuggacaug accgacuucg ucuuccaggc cgcggugccc      540

aagacguucc agcugcagcu ccugagcccc uccagcucca ucgugcccgc cuucaacacc      600

gggaccauca cccaggucau caaggugcug aacccgcaga agcagcagcu ccggaugcgc      660

aucaagcuga cguacaacca caagggcagc gccaugcagg accuggccga ggugaacaac      720

uucccgcccc agagcuggca guga                                             744


<210>  7873
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG51473

<400>  7873
augcgcuccg cccuccucga gcgcaugccc gucauggaga aggucaccac caacggcccc       60

accgagaucg uccagaccaa cggcgagacc gagcccgccc cccucgagac caagcccccc      120

cccuccggcc cccagcccac cucccaggcc aacgaccucc ucgaccuccu cggcggcaac      180

gacaucaccc ccgucauccc caccgccccc accuccaagc ccuccuccgc cggcggcgag      240

cuccucgacc uccucggcga caucaaccuc accggcgccc ccgccgccgc ccccgccccc      300

gccuccgucc cccagaucuc ccagcccccc uuccuccucg acggccucuc cucccagccc      360

cucuucaacg acaucgccgc cggcaucccc uccaucaccg ccuacuccaa gaacggccuc      420

aagaucgagu ucaccuucga gcgcuccaac accaaccccu ccgucaccgu caucaccauc      480

caggccucca acuccaccga gcucgacaug accgacuucg ucuuccaggc cgccgucccc      540

aagaccuucc agcuccagcu ccucuccccc uccuccucca ucguccccgc cuucaacacc      600

ggcaccauca cccaggucau caagguccuc aacccccaga agcagcagcu ccgcaugcgc      660

aucaagcuca ccuacaacca caagggcucc gccaugcagg accucgccga ggucaacaac      720

uucccccccc aguccuggca guga                                             744


<210>  7874
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG51473

<400>  7874
augagaagcg cccugcucga gaggaugccc gugauggaaa aggucaccac aaacggcccu       60

acugagaucg uucagacgaa uggggaaacc gagccagcuc cgcuugaaac aaaacccccu      120

ccauccggac cccaaccuac uucucaggca aacgaccugu uggauuuacu ggguggcaau      180

gacauuaccc cagugauacc cacagccccu accucaaagc caaguagcgc gggaggagag      240

cuacucgauc ugcuuggcga caucaaccug acuggugcuc cggccgcagc ccccgcuccu      300

gcauccguac cacagauuuc ucagcccccu uucuugcucg augggcuguc gucacaacca      360

cuguucaaug acaucgccgc ugggauuccc agcaucacag ccuacaguaa aaacggccuc      420

aagauagagu ucaccuuuga acgguccaau acgaacccgu cugugacugu caucaccauu      480

caggcgagca auuccacaga guuagauaug acugacuucg uguuucaggc agccguuccu      540

aaaaccuucc agcugcaacu uuugucaccc aguagcucua ucgugccagc uuuuaacaca      600

ggcaccauua cgcaggucau caaggugcug aauccucaga agcagcaacu acgcaugcga      660

auaaaacuca cuuauaacca caaggggucc gccaugcagg aucuggcaga aguaaauaac      720

uuucccccac agucauggca auga                                             744


<210>  7875
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG51473

<400>  7875
augagaagcg cccugcugga gagaaugccc gugauggaga aggugaccac caacggcccc       60

accgagaucg ugcagaccaa cggcgagacc gagcccgccc cccuggagac caagcccccc      120

cccagcggcc cccagcccac cagccaggcc aacgaccugc uggaccugcu gggcggcaac      180

gacaucaccc ccgugauccc caccgccccc accagcaagc ccagcagcgc cggcggcgag      240

cugcuggacc ugcugggcga caucaaccug accggcgccc ccgccgccgc ccccgccccc      300

gccagcgugc cccagaucag ccagcccccc uuccugcugg acggccugag cagccagccc      360

cuguucaacg acaucgccgc cggcaucccc agcaucaccg ccuacagcaa gaacggccug      420

aagaucgagu ucaccuucga gagaagcaac accaacccca gcgugaccgu gaucaccauc      480

caggccagca acagcaccga gcuggacaug accgacuucg uguuccaggc cgccgugccc      540

aagaccuucc agcugcagcu gcugagcccc agcagcagca ucgugcccgc cuucaacacc      600

ggcaccauca cccaggugau caaggugcug aacccccaga agcagcagcu gagaaugaga      660

aucaagcuga ccuacaacca caagggcagc gccaugcagg accuggccga ggugaacaac      720

uucccccccc agagcuggca guga                                             744


<210>  7876
<211>  744
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG51473

<400>  7876
augagaagcg cccugcucga gcggaugccc gugauggaaa aggucaccac aaacggcccu       60

acggagaucg uucagaccaa uggggaaaca gagccggcuc cccuggaaac caaaccuccc      120

ccuuccggac cccaaccuac aucucaggcc aacgaccuuc uggaucuccu gggcgggaau      180

gacauuaccc cggugauccc cacagcgccu accagcaagc ccuccucugc uggaggcgag      240

cuucuggauc uccuggggga cauuaaccug acgggagccc cugccgcugc ccccgcuccg      300

gccagcgugc cucagaucuc ccagcccccu uuccuccugg auggccuuuc uagccaaccc      360

cuguuuaaug acauugcggc cggcaucccc uccaucaccg cuuacagcaa aaacgggcuc      420

aagauugagu ucacauuuga acgcucuaau accaacccuu ccgucacagu gaucaccauu      480

caggccagca auucuacgga gcuggauaug acagacuucg uuuuucaggc ugccgugccg      540

aaaaccuucc agcuucaacu gcucuccccc ucuagcucca ucgucccugc guuuaacaca      600

ggaaccauua cccaggugau caagguucug aauccccaga agcagcaacu gagaaugcgg      660

auuaaacuca cauauaacca caagggcagc gccaugcagg aucuggcuga agugaauaac      720

uucccucccc aguccuggca auga                                             744


<210>  7877
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B3KXW5

<400>  7877

Met Glu Lys Asn Ile Asn Leu Arg Asn Cys Gln Thr Leu Asn Thr Tyr 
1               5                   10                  15      


Val Met Leu Thr His Leu Arg Met Pro Ala Pro Ile Arg Leu Arg Glu 
            20                  25                  30          


Leu Ile Arg Thr Ile Arg Thr Ala Arg Thr Gln Ala Glu Glu Arg Glu 
        35                  40                  45              


Met Ile Gln Lys Glu Cys Ala Ala Ile Arg Ser Ser Phe Arg Glu Glu 
    50                  55                  60                  


Asp Asn Thr Tyr Arg Cys Arg Asn Val Ala Lys Leu Leu Tyr Met His 
65                  70                  75                  80  


Met Leu Gly Tyr Pro Ala His Phe Gly Gln Leu Glu Cys Leu Lys Leu 
                85                  90                  95      


Ile Ala Ser Gln Lys Phe Thr Asp Lys Arg Ile Gly Tyr Leu Gly Ala 
            100                 105                 110         


Met Leu Leu Leu Asp Glu Arg Gln Asp Val His Leu Leu Met Thr Asn 
        115                 120                 125             


Cys Ile Lys Asn Asp Leu Asn His Ser Thr Gln Phe Val Gln Gly Leu 
    130                 135                 140                 


Ala Leu Cys Thr Leu Gly Cys Met Gly Ser Ser Glu Met Cys Arg Asp 
145                 150                 155                 160 


Leu Ala Gly Glu Val Glu Lys Leu Leu Lys Thr Ser Asn Ser Tyr Leu 
                165                 170                 175     


Arg Lys Lys Ala Ala Leu Cys Ala Val His Val Ile Arg Lys Val Pro 
            180                 185                 190         


Glu Leu Met Glu Met Phe Leu Pro Ala Thr Lys Asn Leu Leu Asn Glu 
        195                 200                 205             


Lys Asn His Gly Val Leu His Thr Ser Val Val Leu Leu Thr Glu Met 
    210                 215                 220                 


Cys Glu Arg Ser Pro Asp Met Leu Ala His Phe Arg Lys Leu Val Pro 
225                 230                 235                 240 


Gln Leu Val Arg Ile Leu Lys Asn Leu Ile Met Ser Gly Tyr Ser Pro 
                245                 250                 255     


Glu His Asp Val Ser Gly Ile Ser Asp Pro Phe Leu Gln Val Arg Ile 
            260                 265                 270         


Leu Arg Leu Leu Arg Ile Leu Gly Arg Asn Asp Asp Asp Ser Ser Glu 
        275                 280                 285             


Ala Met Asn Asp Ile Leu Ala Gln Val Ala Thr Asn Thr Glu Thr Ser 
    290                 295                 300                 


Lys Asn Val Gly Asn Ala Ile Leu Tyr Glu Thr Val Leu Thr Ile Met 
305                 310                 315                 320 


Asp Ile Lys Ser Glu Ser Gly Leu Arg Val Leu Ala Ile Asn Ile Leu 
                325                 330                 335     


Gly Arg Phe Leu Leu Asn Asn Asp Lys Asn Ile Arg Tyr Val Ala Leu 
            340                 345                 350         


Thr Ser Leu Leu Lys Thr Val Gln Thr Asp His Asn Ala Val Gln Arg 
        355                 360                 365             


His Arg Ser Thr Ile Val Asp Cys Leu Lys Asp Leu Asp Val Ser Ile 
    370                 375                 380                 


Lys Arg Arg Ala Met Glu Leu Ser Phe Ala Leu Val Asn Gly Asn Asn 
385                 390                 395                 400 


Ile Arg Gly Met Met Lys Glu Leu Leu Tyr Phe Leu Asp Ser Cys Glu 
                405                 410                 415     


Pro Glu Phe Lys Ala Asp Cys Ala Ser Gly Ile Phe Leu Ala Ala Glu 
            420                 425                 430         


Lys Tyr Ala Pro Ser Lys Arg Trp His Ile Asp Thr Ile Met Arg Val 
        435                 440                 445             


Leu Thr Thr Ala Gly Ser Tyr Val Arg Asp Asp Ala Val Pro Asn Leu 
    450                 455                 460                 


Ile Gln Leu Ile Thr Asn Ser Val Glu Met His Ala Tyr Thr Val Gln 
465                 470                 475                 480 


Arg Leu Tyr Lys Ala Ile Leu Gly Asp Tyr Ser Gln Gln Pro Leu Val 
                485                 490                 495     


Gln Val Ala Ala Trp Cys Ile Gly Glu Tyr Gly Asp Leu Leu Val Ser 
            500                 505                 510         


Gly Gln Cys Glu Glu Glu Glu Pro Ile Gln Val Thr Glu Asp Glu Val 
        515                 520                 525             


Leu Asp Ile Leu Glu Ser Val Leu Ile Ser Asn Met Ser Thr Ser Val 
    530                 535                 540                 


Thr Arg Gly Tyr Ala Leu Thr Ala Ile Met Lys Leu Ser Thr Arg Phe 
545                 550                 555                 560 


Thr Cys Thr Val Asn Arg Ile Lys Lys Val Val Ser Ile Tyr Gly Ser 
                565                 570                 575     


Ser Ile Asp Val Glu Leu Gln Gln Arg Ala Val Glu Tyr Asn Ala Leu 
            580                 585                 590         


Phe Lys Lys Tyr Asp His Met Arg Ser Ala Leu Leu Glu Arg Met Pro 
        595                 600                 605             


Val Met Glu Lys Val Thr Thr Asn Gly Pro Thr Glu Ile Val Gln Thr 
    610                 615                 620                 


Asn Gly Glu Thr Glu Pro Ala Pro Leu Glu Thr Lys Pro Pro Pro Ser 
625                 630                 635                 640 


Gly Pro Gln Pro Thr Ser Gln Ala Asn Asp Leu Leu Asp Leu Leu Gly 
                645                 650                 655     


Gly Asn Asp Ile Thr Pro Val Ile Pro Thr Ala Pro Thr Ser Lys Pro 
            660                 665                 670         


Ser Ser Ala Gly Gly Glu Leu Leu Asp Leu Leu Gly Asp Ile Asn Leu 
        675                 680                 685             


Thr Gly Ala Pro Ala Ala Ala Pro Ala Pro Ala Ser Val Pro Gln Ile 
    690                 695                 700                 


Ser Gln Pro Pro Phe Leu Leu Asp Gly Leu Ser Ser Gln Pro Leu Phe 
705                 710                 715                 720 


Asn Asp Ile Ala Ala Gly Ile Pro Ser Ile Thr Ala Tyr Ser Lys Asn 
                725                 730                 735     


Gly Leu Lys Ile Glu Phe Thr Phe Glu Arg Ser Asn Thr Asn Pro Ser 
            740                 745                 750         


Val Thr Val Ile Thr Ile Gln Ala Ser Asn Ser Thr Glu Leu Asp Met 
        755                 760                 765             


Thr Asp Phe Val Phe Gln Ala Ala Val Pro Lys Thr Phe Gln Leu Gln 
    770                 775                 780                 


Leu Leu Ser Pro Ser Ser Ser Ile Val Pro Ala Phe Asn Thr Gly Thr 
785                 790                 795                 800 


Ile Thr Gln Val Ile Lys Val Leu Asn Pro Gln Lys Gln Gln Leu Arg 
                805                 810                 815     


Met Arg Ile Lys Leu Thr Tyr Asn His Lys Gly Ser Ala Met Gln Asp 
            820                 825                 830         


Leu Ala Glu Val Asn Asn Phe Pro Pro Gln Ser Trp Gln 
        835                 840                 845 


<210>  7878
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG54627

<400>  7878
auggagaaaa auauuaaucu gaggaacugu caaacacuga acaccuaugu aaugcucacu       60

cauuuaagga ugccagcccc caucagauug cgggagcuga uccggaccau ccggacagcc      120

cgaacccaag cugaagaacg agaaaugauc cagaaagaau gugcugcaau ccggucaucu      180

uuuagagaag aagacaauac auaccgaugu cggaaugugg caaaauuacu guauaugcac      240

augcugggcu acccugcuca cuuuggacag uuggagugcc ucaagcuuau ugccucucaa      300

aaauuuacag acaaacgcau uggcuauuua ggggcaaugc ugcuguuaga ugaaagacaa      360

gauguccauc uucucaugac caacuguauc aagaaugauc uuaaucauag cacgcaauuc      420

guacaggggu uagcacuuug uacccucggc ugcaugggcu ccucagagau gugcagagau      480

cuugcaggag agguagagaa gcuccugaaa accuccaacu cuuacuuaag aaaaaaggca      540

gcacugugug cuguucaugu caucaggaaa guuccugaac uuauggagau guuuuuacca      600

gcaacaaaaa auuuauugaa ugagaagaac cauggugucc uccacacauc uguaguccuc      660

cucacagaaa ugugugagcg aagcccagac augcuugcgc auuucagaaa gcuugugccc      720

caauuaguuc guauuuuaaa gaaccucauc auguccggau auucaccaga acaugauguu      780

ucugguauca gugaccccuu uuugcaggua cgaauuuugc gguuauuaag aauuuuagga      840

cgaaaugaug augauucaag ugaagcuaug aaugauauau uagcacaggu ugccacuaau      900

acugagacua guaaaaaugu aggaaaugcu auucuuuaug aaacgguuuu gacuaucaug      960

gauauuaagu cagagagugg auugcgaguc cuagccauaa auauccuggg ucguuucuua     1020

uugaacaaug acaagaauau uagauaugug gcucugacau cuuuguugaa gacuguacag     1080

acagaucaua augcaguaca gaggcacaga agcacaauug uggacugucu uaaagauuug     1140

gaugucucaa uaaaacggcg ugcaauggaa uugaguuuug cccugguaaa ugggaauaau     1200

auccgaggca ugaugaaaga auuacuuuau uuucuggauu cgugugagcc agaauuuaaa     1260

gcagacugug caucuggaau cuuucuugcu gcagaaaagu augcaccuuc caaacgaugg     1320

cauauagaca caauuaugcg uguuuugaca acggcaggaa guuauguucg ugaugaugca     1380

guccccaauu uaauccaguu aauaacuaau aguguggaga ugcaugccua uacuguccag     1440

cgccuguaca aagcaauucu uggugauuau ucucaacaac cuuugguaca aguggcugca     1500

ugguguauag gugaauaugg ugaucuucuu guaucuggcc agugugaaga ggaagagccu     1560

auucagguaa cagaggauga aguguuggau auuuuagaaa guguccuaau cucuaauaug     1620

uccaccucug ugacacgagg uuaugcccuc acugccauua ugaagcuuuc cacucgauuc     1680

acuuguacug uaaaccgaau uaagaaagug guuuccaucu acggaagcag cauugaugug     1740

gaacuccagc agagggcagu agaauauaau gcacuuuuca agaaauauga ccacaugagg     1800

ucugcccuac uugagagaau gccugucaug gaaaaaguga ccacaaaugg cccuacugag     1860

auugugcaga caaauggaga gacagaacca gcuccacuag agaccaaacc gccacccucu     1920

gggccacagc ccaccagcca ggccaaugau uuauuggauu uguugggagg aaaugacaua     1980

acaccuguua uuccaacugc gccuacaagc aaaccaucuu cugcuggugg agaacuucuu     2040

gauuugcugg gagacaucaa ccuuacaggu gcuccagcug cugcuccugc cccugccuca     2100

gucccacaga uaucccagcc ccccuucuug uuggaugggc uuucaucaca gccucucuuc     2160

aaugauauug cugcaggcau ccccuccauc acagcauaca guaagaaugg cuugaagaua     2220

gaauucaccu uugaacgguc aaauaccaac cccaguguaa cagugauaac gauacaggcc     2280

uccaacagca cagagcuaga uaugacggac uuuguuuucc aagcugcagu accaaagaca     2340

uuccagcugc agcucuuguc uccuagcagc agcauugucc cagcauuuaa cacggggacc     2400

aucacacaag ucauuaaagu ucugaacccu cagaagcaac agcugcgaau gcggaucaag     2460

cuuacauaua aucacaaggg cucagcaaug caagaucuag cagaggugaa caacuuuccc     2520

ccucaguccu ggcaauga                                                   2538


<210>  7879
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG54627

<400>  7879
auggagaaga acaucaaccu gcgcaacugc cagacccuca acaccuacgu gaugcugacg       60

caccuccgga ugcccgcccc gauccgccug cgggagcuga uccgcaccau ccggaccgcc      120

cgcacccagg cggaggagcg ggagaugauc cagaaggagu gcgccgccau ccgcagcucc      180

uuccgggagg aggacaacac guaccgcugc cggaacgucg ccaagcugcu cuacaugcac      240

augcugggcu accccgccca cuucgggcag cuggagugcc ucaagcugau cgcgagccag      300

aaguucaccg acaagcgcau cggcuaccug ggggccaugc uccugcugga cgagcggcag      360

gacgugcacc uccugaugac caacugcauc aagaacgacc ugaaccacuc cacccaguuc      420

gugcagggcc ucgcccugug cacgcugggg ugcaugggca gcuccgagau gugccgcgac      480

cucgccggcg aggucgagaa gcugcugaag accagcaacu ccuaccuccg gaagaaggcg      540

gcccugugcg ccgugcacgu gauccgcaag guccccgagc ugauggagau guuccucccc      600

gccaccaaga accugcugaa cgagaagaac cacggggugc uccacaccag cgugguccug      660

cugacggaga ugugcgagcg guccccggac augcucgccc acuuccgcaa gcuggugccc      720

cagcuggugc ggauccucaa gaaccugauc augagcggcu acucccccga gcacgacguc      780

agcgggaucu ccgaccccuu ccuccaggug cgcauccugc ggcugcugcg cauccucggc      840

cgcaacgacg acgacagcuc cgaggcgaug aacgacaucc uggcccaggu ggccaccaac      900

accgagacca gcaagaacgu cgggaacgcc auccuguacg agacggugcu caccaucaug      960

gacaucaagu ccgagagcgg ccugcgggug cuggccauca acauccucgg ccgcuuccug     1020

cugaacaacg acaagaacau ccgguacguc gcgcugaccu cccuccugaa gaccgugcag     1080

acggaccaca acgccgugca gcgccaccgg agcaccaucg ucgacugccu gaaggaccuc     1140

gacgugagca ucaagcgccg ggccauggag cuguccuucg cccuggugaa cgggaacaac     1200

auccgcggca ugaugaagga gcuccuguac uuccuggaca gcugcgagcc ggaguucaag     1260

gccgacugcg cguccgggau cuuccucgcc gccgagaagu acgcccccag caagcggugg     1320

cacaucgaca ccaucaugcg cguccugacc acggccggcu ccuacgugcg ggacgacgcg     1380

guccccaacc ugauccagcu caucaccaac agcguggaga ugcacgccua caccgugcag     1440

cgccuguaca aggccauccu gggcgacuac ucccagcagc cccucgucca gguggccgcg     1500

uggugcaucg gggaguacgg cgaccugcug gugagcgggc agugcgagga ggaggagccg     1560

auccagguca ccgaggacga ggugcucgac auccuggagu ccgugcugau cagcaacaug     1620

uccacgagcg ucacccgggg cuacgcccuc accgccauca ugaagcuguc cacccgcuuc     1680

acgugcaccg ugaaccggau caagaaggug gucagcaucu acggguccag caucgacgug     1740

gagcugcagc agcgcgccgu ggaguacaac gcccucuuca agaaguacga ccacaugcgg     1800

uccgcgcugc uggagcgcau gcccgucaug gagaagguga ccaccaacgg ccccacggag     1860

aucgugcaga ccaacggcga gaccgagccc gccccgcucg agaccaagcc cccgcccagc     1920

gggccccagc ccaccuccca ggccaacgac cugcuggacc uccugggcgg gaacgacauc     1980

acgcccguca uccccaccgc cccgaccagc aagcccagcu ccgccggcgg ggagcugcuc     2040

gaccugcugg gcgacaucaa ccucaccggc gcgcccgccg ccgcccccgc cccggcgagc     2100

gugccccaga ucucccagcc cccguuccug cuggacgggc ucagcuccca gccccuguuc     2160

aacgacaucg ccgccggcau ccccagcauc acggccuacu ccaagaacgg gcugaagauc     2220

gaguucaccu ucgagcggag caacaccaac cccuccguga ccgucaucac gauccaggcg     2280

agcaacucca ccgagcucga caugaccgac uucguguucc aggccgccgu gccgaagacc     2340

uuccagcugc agcugcucag ccccuccagc uccaucgucc ccgccuucaa cacgggcacc     2400

aucacccagg ugaucaaggu gcugaacccc cagaagcagc agcugcgcau gcgcaucaag     2460

cucaccuaca accacaaggg gagcgccaug caggaccugg cggaggucaa caacuucccg     2520

ccccaguccu ggcaguga                                                   2538


<210>  7880
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG54627

<400>  7880
auggagaaga acaucaaccu ccgcaacugc cagacccuca acaccuacgu caugcucacc       60

caccuccgca ugcccgcccc cauccgccuc cgcgagcuca uccgcaccau ccgcaccgcc      120

cgcacccagg ccgaggagcg cgagaugauc cagaaggagu gcgccgccau ccgcuccucc      180

uuccgcgagg aggacaacac cuaccgcugc cgcaacgucg ccaagcuccu cuacaugcac      240

augcucggcu accccgccca cuucggccag cucgagugcc ucaagcucau cgccucccag      300

aaguucaccg acaagcgcau cggcuaccuc ggcgccaugc uccuccucga cgagcgccag      360

gacguccacc uccucaugac caacugcauc aagaacgacc ucaaccacuc cacccaguuc      420

guccagggcc ucgcccucug cacccucggc ugcaugggcu ccuccgagau gugccgcgac      480

cucgccggcg aggucgagaa gcuccucaag accuccaacu ccuaccuccg caagaaggcc      540

gcccucugcg ccguccacgu cauccgcaag guccccgagc ucauggagau guuccucccc      600

gccaccaaga accuccucaa cgagaagaac cacggcgucc uccacaccuc cgucguccuc      660

cucaccgaga ugugcgagcg cucccccgac augcucgccc acuuccgcaa gcucgucccc      720

cagcucgucc gcauccucaa gaaccucauc auguccggcu acucccccga gcacgacguc      780

uccggcaucu ccgaccccuu ccuccagguc cgcauccucc gccuccuccg cauccucggc      840

cgcaacgacg acgacuccuc cgaggccaug aacgacaucc ucgcccaggu cgccaccaac      900

accgagaccu ccaagaacgu cggcaacgcc auccucuacg agaccguccu caccaucaug      960

gacaucaagu ccgaguccgg ccuccgcguc cucgccauca acauccucgg ccgcuuccuc     1020

cucaacaacg acaagaacau ccgcuacguc gcccucaccu cccuccucaa gaccguccag     1080

accgaccaca acgccgucca gcgccaccgc uccaccaucg ucgacugccu caaggaccuc     1140

gacgucucca ucaagcgccg cgccauggag cucuccuucg cccucgucaa cggcaacaac     1200

auccgcggca ugaugaagga gcuccucuac uuccucgacu ccugcgagcc cgaguucaag     1260

gccgacugcg ccuccggcau cuuccucgcc gccgagaagu acgcccccuc caagcgcugg     1320

cacaucgaca ccaucaugcg cguccucacc accgccggcu ccuacguccg cgacgacgcc     1380

guccccaacc ucauccagcu caucaccaac uccgucgaga ugcacgccua caccguccag     1440

cgccucuaca aggccauccu cggcgacuac ucccagcagc cccucgucca ggucgccgcc     1500

uggugcaucg gcgaguacgg cgaccuccuc gucuccggcc agugcgagga ggaggagccc     1560

auccagguca ccgaggacga gguccucgac auccucgagu ccguccucau cuccaacaug     1620

uccaccuccg ucacccgcgg cuacgcccuc accgccauca ugaagcucuc cacccgcuuc     1680

accugcaccg ucaaccgcau caagaagguc gucuccaucu acggcuccuc caucgacguc     1740

gagcuccagc agcgcgccgu cgaguacaac gcccucuuca agaaguacga ccacaugcgc     1800

uccgcccucc ucgagcgcau gcccgucaug gagaagguca ccaccaacgg ccccaccgag     1860

aucguccaga ccaacggcga gaccgagccc gccccccucg agaccaagcc cccccccucc     1920

ggcccccagc ccaccuccca ggccaacgac cuccucgacc uccucggcgg caacgacauc     1980

acccccguca uccccaccgc ccccaccucc aagcccuccu ccgccggcgg cgagcuccuc     2040

gaccuccucg gcgacaucaa ccucaccggc gcccccgccg ccgcccccgc ccccgccucc     2100

gucccccaga ucucccagcc ccccuuccuc cucgacggcc ucuccuccca gccccucuuc     2160

aacgacaucg ccgccggcau ccccuccauc accgccuacu ccaagaacgg ccucaagauc     2220

gaguucaccu ucgagcgcuc caacaccaac cccuccguca ccgucaucac cauccaggcc     2280

uccaacucca ccgagcucga caugaccgac uucgucuucc aggccgccgu ccccaagacc     2340

uuccagcucc agcuccucuc ccccuccucc uccaucgucc ccgccuucaa caccggcacc     2400

aucacccagg ucaucaaggu ccucaacccc cagaagcagc agcuccgcau gcgcaucaag     2460

cucaccuaca accacaaggg cuccgccaug caggaccucg ccgaggucaa caacuucccc     2520

ccccaguccu ggcaguga                                                   2538


<210>  7881
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG54627

<400>  7881
auggagaaga acaucaaucu gagaaacugc cagacccuca auacauacgu gaugcuuacu       60

caccugagga ugcccgcccc uauucgguug cgcgaauuaa uacgaacgau ccguaccgcu      120

agaacacaag cagaggaaag ggagaugauu cagaaagaau gugccgcgau ccggagcucc      180

uuccgcgagg aggacaacac uuauagaugc aggaaugucg cuaagcugcu auacaugcau      240

augcucggcu auccagccca cuuugggcag cuggaauguc uuaaacugau ugcaucucag      300

aaguucaccg auaaacggau cggauacuug ggugccaugc uccugcugga cgagcgccaa      360

gauguucauc ucuuaaugac aaacugcaua aagaaugacc ugaaccacuc aacccaguuu      420

gugcagggcc uugcuuugug uacucugggg ugcaugggaa guagcgaaau gugucgagau      480

cuagcaggcg agguagagaa gcuccugaaa acauccaauu cuuaucuuag aaagaaagcc      540

gcucugugcg ccgugcaugu caucaggaag gugccggaau ugauggagau guuccucccc      600

gcgaccaaaa accuguuaaa ugaaaagaac cacgguguuc ugcacacguc ggugguccuc      660

cuuacugaga ugugugaacg gucaccugac augcuggcac auuuucguaa guuggugcca      720

cagcuaguac gcauucugaa aaaucucauc augagcgggu acagucccga gcacgauguu      780

uccggaauuu cugacccuuu ccugcaagug agaauccuua ggcuguugcg gauacucggc      840

cgaaacgaug acgauagcuc cgaggccaug aaugacauuc uggcucaggu cgccaccaac      900

acagaaacuu caaagaacgu gggcaaugca aucuuauaug agaccgugcu gacaauuaug      960

gauaucaaaa gugaaagcgg gcuacgcguc cucgcuauca acauucuggg aagauuucuu     1020

uugaauaacg acaagaauau aagguacguu gcccugaccu cucuccugaa aacggugcag     1080

acugaccaua acgcgguaca gcggcaccgc uccacaaucg uggauugccu uaaggaccug     1140

gaugucucaa uuaaaagaag ggccauggag uugagcuucg cacucgugaa ugguaacaau     1200

auccguggca ugaugaagga acuguuauac uuucuggaca guugugagcc agaguucaag     1260

gcugauugcg ccucugggau auuucuagcu gccgaaaaau augcacccuc caagcggugg     1320

cacauugaca ccaucaugcg aguucucacu acagccggaa gcuacgugag agaugacgcu     1380

gucccuaacc ugauccaacu uauuaccaau ucgguggaga ugcaugcgua uacgguacag     1440

agguuguaca aagcaauccu gggcgauuau ucucagcaac cacucguuca gguggccgcu     1500

uggugcauug gugaauacgg ggaccuguua gucuccggac agugugagga agaggagccg     1560

auacagguga ccgaagauga gguccuggac auccuugaau caguguugau uaguaacaug     1620

agcacauccg uuacucgcgg cuaugcccuc accgcaauca ugaagcuguc uacacgguuc     1680

acuugcaccg ugaauagaau caaaaaggua gucagcauuu acggcucaag uauagacgug     1740

gagcuacaac agagggccgu ugaguacaac gcucuguuua agaaauauga ucacaugcgc     1800

uccgcccucc uggaacgaau gcccgugaug gagaagguca caaccaaugg gccuacugaa     1860

aucgugcaga cgaacggaga gacagaacca gcaccccuug agaccaaacc uccacccagc     1920

gguccgcagc cuacuucuca agcgaacgac uugcuggauu uacucggcgg gaaugacauu     1980

acccccguaa ucccaacagc uccuaccuca aagcccagua gcgccggagg cgagcugcuu     2040

gaucuguugg gugacauuaa ccucacuggg gcaccagccg cugcccccgc uccugcaucc     2100

gugccacaga ucucucagcc gcccuuccug cuagauggcc ugucgagcca gccucucuuc     2160

aaugacauag ccgcgggaau cccauccauu acagccuaca gcaaaaacgg ccugaagauc     2220

gaauuuacgu ucgagcggag uaauaccaac cccucuguua cugucauuac aauccaagcu     2280

agcaauucca ccgaacuuga uaugacagac uuuguguucc aggcagccgu gccuaagacu     2340

uuucaguugc agcuguuauc accaucaucu uccauagucc ccgcuuucaa caccgggacg     2400

auuacccaag uuaucaaagu gcucaauccg cagaagcagc aacugcguau gagaauuaaa     2460

cuuacauaua accauaaggg aagugccaug caggaucugg cagaggugaa uaacuuuccu     2520

ccacagagcu ggcaguga                                                   2538


<210>  7882
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG54627

<400>  7882
auggagaaga acaucaaccu gagaaacugc cagacccuga acaccuacgu gaugcugacc       60

caccugagaa ugcccgcccc caucagacug agagagcuga ucagaaccau cagaaccgcc      120

agaacccagg ccgaggagag agagaugauc cagaaggagu gcgccgccau cagaagcagc      180

uucagagagg aggacaacac cuacagaugc agaaacgugg ccaagcugcu guacaugcac      240

augcugggcu accccgccca cuucggccag cuggagugcc ugaagcugau cgccagccag      300

aaguucaccg acaagagaau cggcuaccug ggcgccaugc ugcugcugga cgagagacag      360

gacgugcacc ugcugaugac caacugcauc aagaacgacc ugaaccacag cacccaguuc      420

gugcagggcc uggcccugug cacccugggc ugcaugggca gcagcgagau gugcagagac      480

cuggccggcg agguggagaa gcugcugaag accagcaaca gcuaccugag aaagaaggcc      540

gcccugugcg ccgugcacgu gaucagaaag gugcccgagc ugauggagau guuccugccc      600

gccaccaaga accugcugaa cgagaagaac cacggcgugc ugcacaccag cguggugcug      660

cugaccgaga ugugcgagag aagccccgac augcuggccc acuucagaaa gcuggugccc      720

cagcugguga gaauccugaa gaaccugauc augagcggcu acagccccga gcacgacgug      780

agcggcauca gcgaccccuu ccugcaggug agaauccuga gacugcugag aauccugggc      840

agaaacgacg acgacagcag cgaggccaug aacgacaucc uggcccaggu ggccaccaac      900

accgagacca gcaagaacgu gggcaacgcc auccuguacg agaccgugcu gaccaucaug      960

gacaucaaga gcgagagcgg ccugagagug cuggccauca acauccuggg cagauuccug     1020

cugaacaacg acaagaacau cagauacgug gcccugacca gccugcugaa gaccgugcag     1080

accgaccaca acgccgugca gagacacaga agcaccaucg uggacugccu gaaggaccug     1140

gacgugagca ucaagagaag agccauggag cugagcuucg cccuggugaa cggcaacaac     1200

aucagaggca ugaugaagga gcugcuguac uuccuggaca gcugcgagcc cgaguucaag     1260

gccgacugcg ccagcggcau cuuccuggcc gccgagaagu acgcccccag caagagaugg     1320

cacaucgaca ccaucaugag agugcugacc accgccggca gcuacgugag agacgacgcc     1380

gugcccaacc ugauccagcu gaucaccaac agcguggaga ugcacgccua caccgugcag     1440

agacuguaca aggccauccu gggcgacuac agccagcagc cccuggugca gguggccgcc     1500

uggugcaucg gcgaguacgg cgaccugcug gugagcggcc agugcgagga ggaggagccc     1560

auccagguga ccgaggacga ggugcuggac auccuggaga gcgugcugau cagcaacaug     1620

agcaccagcg ugaccagagg cuacgcccug accgccauca ugaagcugag caccagauuc     1680

accugcaccg ugaacagaau caagaaggug gugagcaucu acggcagcag caucgacgug     1740

gagcugcagc agagagccgu ggaguacaac gcccuguuca agaaguacga ccacaugaga     1800

agcgcccugc uggagagaau gcccgugaug gagaagguga ccaccaacgg ccccaccgag     1860

aucgugcaga ccaacggcga gaccgagccc gccccccugg agaccaagcc cccccccagc     1920

ggcccccagc ccaccagcca ggccaacgac cugcuggacc ugcugggcgg caacgacauc     1980

acccccguga uccccaccgc ccccaccagc aagcccagca gcgccggcgg cgagcugcug     2040

gaccugcugg gcgacaucaa ccugaccggc gcccccgccg ccgcccccgc ccccgccagc     2100

gugccccaga ucagccagcc ccccuuccug cuggacggcc ugagcagcca gccccuguuc     2160

aacgacaucg ccgccggcau ccccagcauc accgccuaca gcaagaacgg ccugaagauc     2220

gaguucaccu ucgagagaag caacaccaac cccagcguga ccgugaucac cauccaggcc     2280

agcaacagca ccgagcugga caugaccgac uucguguucc aggccgccgu gcccaagacc     2340

uuccagcugc agcugcugag ccccagcagc agcaucgugc ccgccuucaa caccggcacc     2400

aucacccagg ugaucaaggu gcugaacccc cagaagcagc agcugagaau gagaaucaag     2460

cugaccuaca accacaaggg cagcgccaug caggaccugg ccgaggugaa caacuucccc     2520

ccccagagcu ggcaguga                                                   2538


<210>  7883
<211>  2538
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG54627

<400>  7883
auggagaaga acaucaaucu gagaaacugc cagacccuca auacauacgu gaugcugacg       60

caccuucgga ugcccgcccc uauucgccug agagaacuca uccggaccau ucgcacagcu      120

agaacccaag ccgaggaacg ggagaugauc cagaaagaau gugcggcuau ucgcagcucc      180

uucagagagg aggacaacac auaucggugc cgcaaugucg ccaagcugcu uuacaugcau      240

augcugggcu auccggccca cuuugggcag cucgaauguc ugaaacugau cgcuucucag      300

aaguucaccg auaaaagaau cggauaccuc ggcgccaugc ugcuucugga cgagcggcaa      360

gauguucauc uccugaugac aaacugcauu aagaaugacc uuaaccacag cacccaguuu      420

gugcaggggc uggcucucug uacgcuggga ugcaugggcu ccucugaaau gugucgcgau      480

cuggccgggg agguggagaa gcuccugaaa accagcaauu ccuaucuuag aaagaaagcg      540

gcccugugcg cuguccaugu gauccggaag guucccgaac ucauggagau guuccugccu      600

gccaccaaaa accuucugaa ugaaaagaac cacggagugc uccacaccuc ugucgugcug      660

cugacagaga ugugugaacg cagccccgac augcucgcuc auuuuagaaa gcugguuccu      720

cagcuugugc ggauucugaa aaaucucauc auguccggcu acagccccga gcacgauguc      780

ucuggcauuu ccgacccuuu ccugcaagug agaauccuuc gccugcuccg gauucugggg      840

agaaacgaug acgauagcuc ugaggccaug aaugacaucc uggcccaggu ggccaccaac      900

acggaaacau ccaagaacgu cggaaaugcu auccucuaug agaccguucu gacaauuaug      960

gauaucaaaa gcgaaucugg ccuucgcgug cuggccauua acauccucgg gcgguuucug     1020

cugaauaacg acaagaauau uagauacgug gcucuuaccu cccuccugaa aaccguccag     1080

acagaccaua acgccgugca gcgccaccgg agcacgaucg uugauugccu gaaggaccuc     1140

gaugugucca ucaaaagacg cgccauggag cugucuuucg cucuugucaa uggaaacaau     1200

auucggggca ugaugaagga acugcucuac uuucuggaca gcugugagcc ggaguucaag     1260

gcggauugcg ccuccgggau cuuucuggcu gccgaaaaau augcccccag caagagaugg     1320

cacauugaca ccaucaugcg cgugcuuaca accgcuggau cuuacguucg ggaugacgcc     1380

gugccuaacc ucauucaacu gaucacaaau uccgucgaga ugcaugcgua uaccgugcag     1440

agacuguaca aagcuauccu cggcgauuau agccagcaac cccuggucca gguggccgcc     1500

uggugcauug gcgaauacgg ggaccuucug guuucuggac agugugagga agaggagccu     1560

auccagguga cggaagauga gguccucgac auucuggaaa gcgugcugau cuccaacaug     1620

ucuacaagcg uuacccgggg cuaugcucuu accgccauua ugaagcucuc cacacgcuuc     1680

acaugcacag ugaauagaau caaaaagguc gugagcauuu acgggucuuc caucgacgug     1740

gagcugcaac agcgggcugu ugaguacaac gcccuguuua agaaauauga ucacaugaga     1800

agcgcgcucc uggaacgcau gcccgucaug gagaagguga cgaccaaugg accgacagaa     1860

aucgugcaga ccaacggcga gacagaaccu gcgccccuug agaccaaacc uccucccucu     1920

gggccccagc cgacguccca agcuaacgac cugcucgauc ugcugggagg caaugacauu     1980

acccccguca ucccuacagc ccccaccagc aagccuuccu cugcuggcgg ggagcuucuc     2040

gaucugcugg gagacauuaa ccucacaggc gcccccgcgg ccgcuccggc cccugcuagc     2100

gugccccaga ucucccagcc ucccuuccug cuugaugggc ugucuagcca gccucucuuc     2160

aaugacauug ccgccggaau ccccuccauc accgcuuaca gcaaaaacgg ccugaagauu     2220

gaauuuacgu ucgagcgguc uaauacaaac ccguccguua ccgugaucac aauucaagcg     2280

agcaauucua ccgaacugga uaugaccgac uuugucuucc aggccgcugu gccuaagaca     2340

uuucagcuuc agcugcucuc ccccagcucu agcaucguuc ccgccuucaa cacggggacc     2400

auuacacaag ugaucaaagu ccugaauccu cagaagcagc aacucagaau gcgcaucaaa     2460

cugaccuaua accauaaggg cuccgccaug caggaucuug cugaggugaa uaacuuuccg     2520

ccccagagcu ggcaguga                                                   2538


<210>  7884
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B4DED9

<400>  7884

Met Ala Asp Arg Ala Glu Met Phe Ser Leu Ser Thr Phe His Ser Leu 
1               5                   10                  15      


Ser Pro Pro Gly Cys Arg Pro Pro Gln Asp Ile Ser Leu Glu Glu Phe 
            20                  25                  30          


Asp Asp Glu Asp Leu Ser Glu Ile Thr Asp Asp Cys Gly Leu Gly Leu 
        35                  40                  45              


Ser Tyr Asp Ser Asp His Cys Glu Lys Asp Ser Leu Ser Leu Gly Arg 
    50                  55                  60                  


Ser Glu Gln Pro His Pro Ile Cys Ser Phe Gln Asp Asp Phe Gln Glu 
65                  70                  75                  80  


Phe Glu Met Ile Asp Val Asn Gly Glu Glu Arg Glu Gln Thr His Arg 
                85                  90                  95      


Ala Val Phe Arg Phe Ile Pro Arg His Pro Asp Glu Leu Glu Leu Asp 
            100                 105                 110         


Val Asp Asp Pro Val Leu Val Glu Ala Glu Glu Asp Asp Phe Trp Phe 
        115                 120                 125             


Arg Gly Phe Asn Met Arg Thr Gly Glu Arg Gly Val Phe Pro Ala Phe 
    130                 135                 140                 


Tyr Ala His Ala Val Pro Gly Pro Ala Lys Asp Leu Leu Gly Ser Lys 
145                 150                 155                 160 


Arg Ser Pro Cys Trp Val Glu Arg Phe Asp Val Gln Phe Leu Gly Ser 
                165                 170                 175     


Val Glu Val Pro Cys His Gln Gly Asn Gly Ile Leu Cys Ala Ala Met 
            180                 185                 190         


Gln Lys Ile Ala Thr Ala Arg Lys Leu Thr Val His Leu Arg Pro Pro 
        195                 200                 205             


Ala Ser Cys Asp Leu Glu Ile Ser Leu Arg Gly Val Lys Leu Ser Leu 
    210                 215                 220                 


Ser Gly Gly Gly Pro Glu Phe Gln Arg Cys Ser His Phe Phe Gln Met 
225                 230                 235                 240 


Lys Asn Ile Ser Phe Cys Gly Cys His Pro Arg Asn Ser Cys Tyr Phe 
                245                 250                 255     


Gly Phe Ile Thr Lys His Pro Leu Leu Ser Arg Phe Ala Cys His Val 
            260                 265                 270         


Phe Val Ser Gln Glu Ser Met Arg Pro Val Ala Gln Ser Val Gly Arg 
        275                 280                 285             


Ala Phe Leu Glu Tyr Tyr Gln Glu His Leu Ala Tyr Ala Cys Pro Thr 
    290                 295                 300                 


Glu Asp Ile Tyr Leu Glu 
305                 310 


<210>  7885
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG57050

<400>  7885
auggcggauc gcgcggagau guuuucucuc uccaccuucc acucgcuguc gccgccgggc       60

ugcaggccuc cccaggacau aagccuggaa gaauuugacg acgaagaucu gucugagauc      120

acugaugacu guggccuggg ccucagcuac gacucagacc acugugagaa ggacagccuc      180

ucccuggggc gcucggagca gccgcacccc aucugcuccu uccaggauga cuuccaggag      240

uuugagauga ucgaugucaa cggcgaggag cgagagcaga cucaccgggc uguguucagg      300

uucaucccgc ggcauccaga cgagcuggag cuggaugugg augacccugu guugguggag      360

gccgaggagg acgacuucug guuccguggc uucaacaugc gcacggggga gcgcggugug      420

uuuccugccu ucuacgccca ugcggugccc ggcccugcca aggaccugcu ggggaguaag      480

cggagccccu gcugggugga gcgcuuugac gugcaguucc ugggcuccgu ggaggugccc      540

ugccaccagg gcaacggcau ccugugugca gccaugcaga agauugccac ugcccggaaa      600

cugaccgucc accugcgccc uccugccucc ugugaccucg agaucucucu ucgggggguc      660

aagcugaguc ugagcggagg agggccugag uuccagcgcu gcagccauuu cuuccagaug      720

aagaacaucu ccuucugcgg cugccauccc cgcaacagcu gcuauuucgg cuucaucacc      780

aaacaccccc ugcugagccg cuucgccugc cacgucuuug ucucccagga guccaugagg      840

ccaguggcgc agaguguggg ccgcgccuuc cuggaguacu accaagagca ccuggcguac      900

gccugcccca cggaggacau cuaccuggag uag                                   933


<210>  7886
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG57050

<400>  7886
auggccgacc gcgccgagau guucagccug uccaccuucc acagccucuc cccgcccggc       60

ugccggccgc cccaggacau cagccuggag gaguucgacg acgaggaccu guccgagauc      120

accgacgacu gcgggcucgg ccugagcuac gacuccgacc acugcgagaa ggacagccug      180

ucccucgggc gcagcgagca gccccacccc aucugcuccu uccaggacga cuuccaggag      240

uucgagauga ucgacgugaa cggcgaggag cgggagcaga cgcaccgcgc ggucuuccgg      300

uucauccccc gccaccccga cgagcuggag cuggacgugg acgaccccgu gcucgucgag      360

gccgaggagg acgacuucug guuccggggg uucaacaugc gcaccggcga gcggggcgug      420

uucccggccu ucuacgccca cgccgugccc gggcccgcga aggaccugcu gggcagcaag      480

cgcucccccu gcugggucga gcgguucgac gugcaguucc ucgggagcgu ggaggucccg      540

ugccaccagg gcaacgggau ccugugcgcc gccaugcaga agaucgccac cgcgcgcaag      600

cugaccgugc accuccggcc gcccgccucc ugcgaccugg agaucagccu gcgcggcgug      660

aagcucuccc ugagcggcgg gggccccgag uuccagcggu gcucccacuu cuuccagaug      720

aagaacauca gcuucugcgg gugccacccc cgcaacagcu gcuacuucgg cuucaucacg      780

aagcaccccc ugcucucccg guucgccugc cacgucuucg ugagccagga guccaugcgc      840

cccguggccc agagcgucgg ccgggccuuc cuggaguacu accaggagca ccuggcguac      900

gccugcccca ccgaggacau cuaccucgag uga                                   933


<210>  7887
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG57050

<400>  7887
auggccgacc gcgccgagau guucucccuc uccaccuucc acucccucuc cccccccggc       60

ugccgccccc cccaggacau cucccucgag gaguucgacg acgaggaccu cuccgagauc      120

accgacgacu gcggccucgg ccucuccuac gacuccgacc acugcgagaa ggacucccuc      180

ucccucggcc gcuccgagca gccccacccc aucugcuccu uccaggacga cuuccaggag      240

uucgagauga ucgacgucaa cggcgaggag cgcgagcaga cccaccgcgc cgucuuccgc      300

uucauccccc gccaccccga cgagcucgag cucgacgucg acgaccccgu ccucgucgag      360

gccgaggagg acgacuucug guuccgcggc uucaacaugc gcaccggcga gcgcggcguc      420

uuccccgccu ucuacgccca cgccgucccc ggccccgcca aggaccuccu cggcuccaag      480

cgcucccccu gcugggucga gcgcuucgac guccaguucc ucggcuccgu cgaggucccc      540

ugccaccagg gcaacggcau ccucugcgcc gccaugcaga agaucgccac cgcccgcaag      600

cucaccgucc accuccgccc ccccgccucc ugcgaccucg agaucucccu ccgcggcguc      660

aagcucuccc ucuccggcgg cggccccgag uuccagcgcu gcucccacuu cuuccagaug      720

aagaacaucu ccuucugcgg cugccacccc cgcaacuccu gcuacuucgg cuucaucacc      780

aagcaccccc uccucucccg cuucgccugc cacgucuucg ucucccagga guccaugcgc      840

cccgucgccc aguccgucgg ccgcgccuuc cucgaguacu accaggagca ccucgccuac      900

gccugcccca ccgaggacau cuaccucgag uga                                   933


<210>  7888
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG57050

<400>  7888
auggccgaca gagcugagau guucagccug uccaccuuuc acucucucuc acccccuggc       60

ugcaggccac cgcaggauau cagucuugaa gaguucgacg augaagaccu gagcgagauu      120

acagaugacu guggguuggg auuauccuac gauucugacc auugcgaaaa ggauucgcug      180

ucacuagguc ggagcgagca accccacccu auauguaguu uucaggacga uuuccaggag      240

uuugaaauga ucgacgugaa cggcgaggaa cgcgagcaga cucaucgagc agucuuccgu      300

uuuauuccaa gacaccccga ugagcucgaa cuggacguug acgauccugu gcuuguagag      360

gccgaagagg acgauuucug guuuaggggg uucaauaugc ggacgggaga acgcggcgug      420

uuuccagcgu ucuaugcuca ugccgucccc gguccugcaa aagaccuguu gggguccaag      480

agaucuccau gcugggugga gagguuugau guucaauucc ucggaagcgu ggaggucccg      540

ugucaccagg gcaacggcau ccugugcgcc gcuaugcaga aaauugcaac cgcccggaag      600

cugacagugc accuccgacc cccugcuucc ugugacuuag aaaucucacu gcgcggggua      660

aaacuuaguu ugagcggagg uggcccagag uuccagagau gcucucacuu uuuccaaaug      720

aagaauauau ccuuuugugg gugccauccc aggaacucau guuacuucgg auuuaucacu      780

aagcauccuc ugcuaagccg guucgccugc cacguuuuug ugagucagga aucuaugcgu      840

ccagucgcgc aguccguggg ccgcgcauuc cucgaguauu accaggaaca ccuggccuau      900

gcuugcccca ccgaggauau uuaccuugag uga                                   933


<210>  7889
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG57050

<400>  7889
auggccgaca gagccgagau guucagccug agcaccuucc acagccugag cccccccggc       60

ugcagacccc cccaggacau cagccuggag gaguucgacg acgaggaccu gagcgagauc      120

accgacgacu gcggccuggg ccugagcuac gacagcgacc acugcgagaa ggacagccug      180

agccugggca gaagcgagca gccccacccc aucugcagcu uccaggacga cuuccaggag      240

uucgagauga ucgacgugaa cggcgaggag agagagcaga cccacagagc cguguucaga      300

uucaucccca gacaccccga cgagcuggag cuggacgugg acgaccccgu gcugguggag      360

gccgaggagg acgacuucug guucagaggc uucaacauga gaaccggcga gagaggcgug      420

uuccccgccu ucuacgccca cgccgugccc ggccccgcca aggaccugcu gggcagcaag      480

agaagccccu gcugggugga gagauucgac gugcaguucc ugggcagcgu ggaggugccc      540

ugccaccagg gcaacggcau ccugugcgcc gccaugcaga agaucgccac cgccagaaag      600

cugaccgugc accugagacc ccccgccagc ugcgaccugg agaucagccu gagaggcgug      660

aagcugagcc ugagcggcgg cggccccgag uuccagagau gcagccacuu cuuccagaug      720

aagaacauca gcuucugcgg cugccacccc agaaacagcu gcuacuucgg cuucaucacc      780

aagcaccccc ugcugagcag auucgccugc cacguguucg ugagccagga gagcaugaga      840

cccguggccc agagcguggg cagagccuuc cuggaguacu accaggagca ccuggccuac      900

gccugcccca ccgaggacau cuaccuggag uga                                   933


<210>  7890
<211>  933
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG57050

<400>  7890
auggccgaca gagcugagau guucagccug uccaccuuuc acucucucag cccucccggc       60

ugccggccgc cccaggauau cucccuggaa gaguucgacg augaagaccu uucugagauu      120

acagaugacu gugggcuggg acucagcuac gauuccgacc auugcgaaaa ggauucucug      180

agccuuggcc gcuccgagca accucacccc aucuguagcu uucaggacga uuuccaggag      240

uuugaaauga uugacgugaa cggggaggaa agagagcaga cgcaucgggc cgucuuccgc      300

uuuaucccua gacaccccga ugagcuggaa cucgacguug acgauccugu gcugguggag      360

gcggaagagg acgauuucug guuucgggga uucaauaugc gcaccggcga aagagggguc      420

uuuccggcuu ucuaugccca ugccgugccc ggaccugcua aagaccugcu cggcucuaag      480

cggucccccu gcuggguuga gcgcuuugau gugcaauucc ugggcagcgu cgaggugccu      540

ugucaccagg ggaacggcau ucuuugcgcc gcuaugcaga aaaucgccac agcgagaaag      600

cugaccguuc accuccggcc cccggccucu ugugaccugg aaaucucccu ucgcggagug      660

aaacugagcc ucucuggggg aggcccugag uuccagagau gcucccacuu uuuccaaaug      720

aagaauauua gcuuuugugg gugccauccc cggaacuccu guuacuucgg auuuaucaca      780

aagcauccuc ugcugucucg cuucgcuugc cacgucuuug ugagccagga auccaugaga      840

cccguggccc agagcgucgg ccgggcuuuc cucgaguauu accaggaaca ccuggccuau      900

gcgugcccca ccgaggauau uuaccuugag uga                                   933


<210>  7891
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B4DFU7

<400>  7891

Met Ala Asp Arg Ala Glu Met Phe Ser Leu Ser Thr Phe His Ser Leu 
1               5                   10                  15      


Ser Pro Pro Gly Cys Arg Pro Pro Gln Asp Ile Ser Leu Glu Glu Phe 
            20                  25                  30          


Asp Asp Glu Asp Leu Ser Glu Ile Thr Asp Asp Cys Gly Leu Gly Leu 
        35                  40                  45              


Ser Tyr Asp Ser Asp His Cys Glu Lys Asp Ser Leu Ser Leu Gly Arg 
    50                  55                  60                  


Ser Glu Gln Pro His Pro Ile Cys Ser Phe Gln Asp Asp Phe Gln Glu 
65                  70                  75                  80  


Phe Glu Met Ile Asp Asp Asn Glu Glu Glu Asp Asp Glu Asp Glu Glu 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Gly Gln Glu Gly Gly 
            100                 105                 110         


Asp Pro Gly Ser Glu Ala Pro Ala Pro Gly Pro Leu Ile Pro Ser Pro 
        115                 120                 125             


Ser Val Glu Glu Pro His Lys His Arg Pro Thr Thr Leu Arg Leu Thr 
    130                 135                 140                 


Thr Leu Gly Ala Gln Asp Ser Leu Asn Asn Asn Gly Gly Phe Asp Leu 
145                 150                 155                 160 


Val Arg Pro Ala Ser Trp Gln Glu Thr Ala Leu Cys Ser Pro Ala Pro 
                165                 170                 175     


Glu Ala Leu Arg Glu Leu Pro Gly Pro Leu Pro Ala Thr Asp Thr Gly 
            180                 185                 190         


Pro Gly Gly Ala Gln Ser Pro Val Arg Pro Gly Cys Asp Cys Glu Gly 
        195                 200                 205             


Asn Arg Pro Ala Glu Pro Pro Ala Pro Gly Gly Thr Ser Pro Ser Ser 
    210                 215                 220                 


Asp Pro Gly Ile Glu Ala Asp Leu Arg Ser Arg Ser Ser Gly Gly Arg 
225                 230                 235                 240 


Gly Gly Arg Arg Ser Ser Gln Glu Leu Ser Ser Pro Gly Ser Asp Ser 
                245                 250                 255     


Glu Asp Ala Gly Gly Ala Arg Leu Gly Arg Met Ile Ser Ser Ile Ser 
            260                 265                 270         


Glu Thr Glu Leu Glu Leu Ser Ser Asp Gly Gly Ser Ser Ser Ser Gly 
        275                 280                 285             


Arg Ser Ser His Leu Thr Phe Ser Lys Lys Phe Leu Asn Val Phe Val 
    290                 295                 300                 


Asn Ser Thr Ser Arg Ser Ser Ser Thr Glu Ser Phe Gly Leu Phe Ser 
305                 310                 315                 320 


Cys Leu Val Asn Gly Glu Glu Arg Glu Gln Thr His Arg Ala Val Phe 
                325                 330                 335     


Arg Phe Ile Pro Arg His Pro Asp Glu Leu Glu Leu Asp Val Asp Asp 
            340                 345                 350         


Pro Val Leu Val Glu Ala Glu Glu Asp Asp Phe Trp Phe Arg Gly Phe 
        355                 360                 365             


Asn Met Arg Thr Gly Glu Arg Gly Val Phe Pro Ala Phe Tyr Ala His 
    370                 375                 380                 


Ala Val Pro Gly Pro Ala Lys Asp Leu Leu Gly Ser Lys Arg Ser Pro 
385                 390                 395                 400 


Cys Trp Val Glu Arg Phe Asp Val Gln Phe Leu Gly Ser Val Glu Val 
                405                 410                 415     


Pro Cys His Gln Gly Asn Gly Ile Leu Cys Ala Ala Met Gln Lys Ile 
            420                 425                 430         


Ala Thr Ala Arg Lys Leu Thr Val His Leu Arg Pro Pro Ala Ser Cys 
        435                 440                 445             


Asp Leu Glu Ile Ser Leu Arg Gly Val Lys Leu Ser Leu Ser Gly Gly 
    450                 455                 460                 


Gly Pro Glu Phe Gln Arg Cys Ser His Phe Phe Gln Met Lys Asn Ile 
465                 470                 475                 480 


Ser Phe Cys Gly Cys His Pro Arg Asn Ser Cys Tyr Phe Gly Phe Ile 
                485                 490                 495     


Thr Lys His Pro Leu Leu Ser Arg Phe Ala Cys His Val Phe Val Ser 
            500                 505                 510         


Gln Glu Ser Met Arg Pro Val Ala Gln Ser Val Gly Arg Ala Phe Leu 
        515                 520                 525             


Glu Tyr Tyr Gln Glu His Leu Ala Tyr Ala Cys Pro Thr Glu Asp Ile 
    530                 535                 540                 


Tyr Leu Glu 
545         


<210>  7892
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG57558

<400>  7892
auggcggauc gcgcggagau guuuucucuc uccaccuucc acucgcuguc gccgccgggc       60

ugcaggccuc cccaggacau aagccuggaa gaauuugacg acgaagaucu gucugagauc      120

acugaugacu guggccuggg ccucagcuac gacucagacc acugugagaa ggacagccuc      180

ucccuggggc gcucggagca gccgcacccc aucugcuccu uccaggauga cuuccaggag      240

uuugagauga ucgaugacaa ugaagaggag gacgaugagg acgaggaaga ggaggaggag      300

gaggaggagg gagaugggga aggccaggag ggaggagacc cuggcucaga ggcaccugcc      360

cccgggcccc uuauccccuc cccuuccgug gaggagcccc acaagcaccg gcccaccacc      420

cuccgucuga ccacacuggg ggcccaggac ucccuaaaca acaacggagg cuuugaccug      480

gugcguccgg ccuccuggca ggagacagcg cuaugcucac ccgccccgga ggcccucaga      540

gagcucccgg gcccccuccc ugccacggac accgggcccg gcggggcgca gucgccagug      600

cgcccggguu gcgacugcga agggaaccgg ccugcggaac cccccgcgcc aggggggacu      660

ucgcccuccu cagaucccgg caucgaggcu gaccugagaa gccgcucgag cggcggccgc      720

gggggacguc gcagcagcca ggagcugucc ucgcccggcu ccgacucgga ggacgcgggc      780

ggcgcgcgcc uggggcgcau gaucucgucc aucucggaga cggagcugga gcugagcagc      840

gauggcggaa gcagcagcag cggccgcucc ucgcaccuca cuuucuccaa gaaguuccuc      900

aaugucuucg ucaacagcac aucucggucc uccagcaccg aguccuuugg ccuuuucucc      960

ugucugguca acggcgagga gcgagagcag acucaccggg cuguguucag guucaucccg     1020

cggcauccag acgagcugga gcuggaugug gaugacccug uguuggugga ggccgaggag     1080

gacgacuucu gguuccgugg cuucaacaug cgcacggggg agcgcggugu guuuccugcc     1140

uucuacgccc augcggugcc cggcccugcc aaggaccugc uggggaguaa gcggagcccc     1200

ugcugggugg agcgcuuuga cgugcaguuc cugggcuccg uggaggugcc cugccaccag     1260

ggcaacggca uccugugugc agccaugcag aagauugcca cugcccggaa acugaccguc     1320

caccugcgcc cuccugccuc cugugaccuc gagaucucuc uucggggggu caagcugagu     1380

cugagcggag gagggccuga guuccagcgc ugcagccauu ucuuccagau gaagaacauc     1440

uccuucugcg gcugccaucc ccgcaacagc ugcuauuucg gcuucaucac caaacacccc     1500

cugcugagcc gcuucgccug ccacgucuuu gucucccagg aguccaugag gccgguggcg     1560

cagagugugg gccgcgccuu ccuggaguac uaccaagagc accuggcgua cgccugcccc     1620

acggaggaca ucuaccugga guag                                            1644


<210>  7893
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG57558

<400>  7893
auggccgacc gcgccgagau guucagccug uccaccuucc acagccucuc cccgcccggc       60

ugccggccgc cccaggacau cagccuggag gaguucgacg acgaggaccu guccgagauc      120

accgacgacu gcgggcucgg ccugagcuac gacuccgacc acugcgagaa ggacagccug      180

ucccucgggc gcagcgagca gccccacccc aucugcuccu uccaggacga cuuccaggag      240

uucgagauga ucgacgacaa cgaggaggag gacgacgagg acgaggagga ggaggaggag      300

gaggaggagg gcgacgggga gggccaggag ggcggggacc ccggcagcga ggcgcccgcc      360

cccgggccgc ugauccccuc ccccagcgug gaggagcccc acaagcaccg gccgacgacc      420

cugcgccuca ccacccuggg cgcccaggac ucccugaaca acaacggggg cuucgaccuc      480

guccggcccg ccagcuggca ggagacggcc cugugcuccc ccgcgcccga ggcccugcgc      540

gagcucccgg gcccccugcc cgccaccgac accgggcccg gcggggccca gagcccggug      600

cggcccggcu gcgacugcga gggcaaccgc cccgcggagc ccccggcccc cgggggcacc      660

ucccccagca gcgaccccgg gaucgaggcc gaccugcggu cccgcagcuc cggcgggcgg      720

ggcggccgcc ggagcuccca ggagcucagc uccccgggga gcgacuccga ggacgccggc      780

ggggcccgcc ugggccggau gaucagcucc aucagcgaga cggagcugga gcucuccagc      840

gacgggggcu ccagcuccag cggccgcucc agccaccuga ccuucagcaa gaaguuccug      900

aacguguucg ucaacuccac cagccggucc agcuccaccg agagcuucgg gcuguucucc      960

ugccugguga acggcgagga gcgcgagcag acgcaccggg cgguguuccg cuucaucccc     1020

cggcaccccg acgagcugga gcucgacguc gacgacccgg ugcuggugga ggccgaggag     1080

gacgacuucu gguuccgcgg guucaacaug cgcaccggcg agcgcggggu cuuccccgcc     1140

uucuacgccc acgccgugcc cggccccgcg aaggaccugc ucggcagcaa gcgguccccg     1200

ugcugggugg agcgguucga cguccaguuc cuggggagcg uggaggugcc cugccaccag     1260

ggcaacggga uccugugcgc cgccaugcag aagaucgcca ccgcccgcaa gcucaccguc     1320

caccuccggc cgcccgcguc cugcgaccug gagaucagcc uccgcggcgu gaagcugucc     1380

cugagcggcg ggggccccga guuccagcgg ugcucccacu ucuuccagau gaagaacauc     1440

agcuucugcg ggugccaccc ccgcaacucc ugcuacuucg gcuucaucac gaagcacccc     1500

cuccugagcc gguucgccug ccacguguuc gucagccagg aguccaugcg ccccguggcc     1560

cagagcgugg ggcgggccuu ccuggaguac uaccaggagc accucgccua cgcgugcccg     1620

accgaggaca ucuaccugga guga                                            1644


<210>  7894
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG57558

<400>  7894
auggccgacc gcgccgagau guucucccuc uccaccuucc acucccucuc cccccccggc       60

ugccgccccc cccaggacau cucccucgag gaguucgacg acgaggaccu cuccgagauc      120

accgacgacu gcggccucgg ccucuccuac gacuccgacc acugcgagaa ggacucccuc      180

ucccucggcc gcuccgagca gccccacccc aucugcuccu uccaggacga cuuccaggag      240

uucgagauga ucgacgacaa cgaggaggag gacgacgagg acgaggagga ggaggaggag      300

gaggaggagg gcgacggcga gggccaggag ggcggcgacc ccggcuccga ggcccccgcc      360

cccggccccc ucauccccuc ccccuccguc gaggagcccc acaagcaccg ccccaccacc      420

cuccgccuca ccacccucgg cgcccaggac ucccucaaca acaacggcgg cuucgaccuc      480

guccgccccg ccuccuggca ggagaccgcc cucugcuccc ccgcccccga ggcccuccgc      540

gagcuccccg gcccccuccc cgccaccgac accggccccg gcggcgccca gucccccguc      600

cgccccggcu gcgacugcga gggcaaccgc cccgccgagc cccccgcccc cggcggcacc      660

ucccccuccu ccgaccccgg caucgaggcc gaccuccgcu cccgcuccuc cggcggccgc      720

ggcggccgcc gcuccuccca ggagcucucc ucccccggcu ccgacuccga ggacgccggc      780

ggcgcccgcc ucggccgcau gaucuccucc aucuccgaga ccgagcucga gcucuccucc      840

gacggcggcu ccuccuccuc cggccgcucc ucccaccuca ccuucuccaa gaaguuccuc      900

aacgucuucg ucaacuccac cucccgcucc uccuccaccg aguccuucgg ccucuucucc      960

ugccucguca acggcgagga gcgcgagcag acccaccgcg ccgucuuccg cuucaucccc     1020

cgccaccccg acgagcucga gcucgacguc gacgaccccg uccucgucga ggccgaggag     1080

gacgacuucu gguuccgcgg cuucaacaug cgcaccggcg agcgcggcgu cuuccccgcc     1140

uucuacgccc acgccguccc cggccccgcc aaggaccucc ucggcuccaa gcgcuccccc     1200

ugcugggucg agcgcuucga cguccaguuc cucggcuccg ucgagguccc cugccaccag     1260

ggcaacggca uccucugcgc cgccaugcag aagaucgcca ccgcccgcaa gcucaccguc     1320

caccuccgcc cccccgccuc cugcgaccuc gagaucuccc uccgcggcgu caagcucucc     1380

cucuccggcg gcggccccga guuccagcgc ugcucccacu ucuuccagau gaagaacauc     1440

uccuucugcg gcugccaccc ccgcaacucc ugcuacuucg gcuucaucac caagcacccc     1500

cuccucuccc gcuucgccug ccacgucuuc gucucccagg aguccaugcg ccccgucgcc     1560

caguccgucg gccgcgccuu ccucgaguac uaccaggagc accucgccua cgccugcccc     1620

accgaggaca ucuaccucga guga                                            1644


<210>  7895
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG57558

<400>  7895
auggccgaca gagcugagau guucagccug uccaccuuuc acucucucuc acccccuggc       60

ugcaggccac cgcaggauau cagucuugaa gaguucgacg augaagaccu gagcgagauu      120

acagaugacu guggguuggg auuauccuac gauucugacc auugcgaaaa ggauucgcug      180

ucacuagguc ggagcgagca accccacccu auauguaguu uucaggacga uuuccaggag      240

uuugaaauga ucgacgauaa cgaggaagag gacgacgagg augaagagga agaggaagag      300

gaggaagagg gcgacgggga aggacaggag ggcggugauc caggguccga agcacccgcc      360

ccuggaccac ucauucccuc uccuagcgug gaggagccac auaaacaccg cccgacuacg      420

cugcgacuua ccacacuggg cgcgcaagac uccuugaaua acaauggcgg guucgaucuc      480

guccgucccg cuucauggca ggaaacugcc cugugcaguc cugcaccaga ggcccugaga      540

gaacuccccg gaccuuuacc agcuaccgac acaggucccg gcggggcaca gagcccgguu      600

aggccuggau gugauugcga gggcaaccgg cccgccgaac ccccugcucc cggugggacc      660

ucuccauccu cagaccccgg aaucgaggcc gaucugcgca gcagaaguuc uggcggcagg      720

ggaggacggc gcuccagcca ggagcuuucg ucuccugguu ccgacucaga agaugcgggc      780

ggggcacgau ugggaagaau gauuaguagc aucuccgaga cugaacugga gcuaucuagc      840

gacggcgguu caaguuccag cgggaggucu ucacaucuca cauuuaguaa gaaauuccug      900

aauguguuug uaaacagcac cucccggucu ucgagcacgg aguccuucgg ccuguuuuca      960

ugucuuguga auggagagga acgugaacaa acucaccgcg ccgucuucag auuuauacca     1020

aggcacccgg acgaguugga acucgaugug gacgaucccg uucuggugga ggcugaggaa     1080

gacgauuucu gguuccgggg cuuuaacaug cgaaccgggg agcgcggagu cuucccugcc     1140

uuuuaugcac augcugugcc aggucccgcc aaggacuuac ugggcaguaa aagaucuccu     1200

ugcuggguag aaagguucga uguucaguuu cucgggagcg uggagguccc augucaccag     1260

ggaaauggca uccuuugcgc ggccaugcag aagauugcaa cagcucggaa gcugacugug     1320

cauuugcgcc caccggccuc cugugaccua gaaaucucac ugagaggugu gaaacucagc     1380

cugucugggg gcggaccuga guuccaaagg ugcucccacu uuuuccagau gaagaacauu     1440

aguuuuugcg gcugucaccc acguaauagc ugcuacuucg gguuuaucac caaacauccc     1500

cuucugucuc gguucgcuug ucacgucuuu guuucccagg agucaaugcg accuguggcc     1560

caaaguguag ggagagcauu cuuggaauau uaccaggagc aucucgccua ugcuugcccc     1620

acagaagaua uauaccugga guga                                            1644


<210>  7896
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG57558

<400>  7896
auggccgaca gagccgagau guucagccug agcaccuucc acagccugag cccccccggc       60

ugcagacccc cccaggacau cagccuggag gaguucgacg acgaggaccu gagcgagauc      120

accgacgacu gcggccuggg ccugagcuac gacagcgacc acugcgagaa ggacagccug      180

agccugggca gaagcgagca gccccacccc aucugcagcu uccaggacga cuuccaggag      240

uucgagauga ucgacgacaa cgaggaggag gacgacgagg acgaggagga ggaggaggag      300

gaggaggagg gcgacggcga gggccaggag ggcggcgacc ccggcagcga ggcccccgcc      360

cccggccccc ugauccccag ccccagcgug gaggagcccc acaagcacag acccaccacc      420

cugagacuga ccacccuggg cgcccaggac agccugaaca acaacggcgg cuucgaccug      480

gugagacccg ccagcuggca ggagaccgcc cugugcagcc ccgcccccga ggcccugaga      540

gagcugcccg gcccccugcc cgccaccgac accggccccg gcggcgccca gagccccgug      600

agacccggcu gcgacugcga gggcaacaga cccgccgagc cccccgcccc cggcggcacc      660

agccccagca gcgaccccgg caucgaggcc gaccugagaa gcagaagcag cggcggcaga      720

ggcggcagaa gaagcagcca ggagcugagc agccccggca gcgacagcga ggacgccggc      780

ggcgccagac ugggcagaau gaucagcagc aucagcgaga ccgagcugga gcugagcagc      840

gacggcggca gcagcagcag cggcagaagc agccaccuga ccuucagcaa gaaguuccug      900

aacguguucg ugaacagcac cagcagaagc agcagcaccg agagcuucgg ccuguucagc      960

ugccugguga acggcgagga gagagagcag acccacagag ccguguucag auucaucccc     1020

agacaccccg acgagcugga gcuggacgug gacgaccccg ugcuggugga ggccgaggag     1080

gacgacuucu gguucagagg cuucaacaug agaaccggcg agagaggcgu guuccccgcc     1140

uucuacgccc acgccgugcc cggccccgcc aaggaccugc ugggcagcaa gagaagcccc     1200

ugcugggugg agagauucga cgugcaguuc cugggcagcg uggaggugcc cugccaccag     1260

ggcaacggca uccugugcgc cgccaugcag aagaucgcca ccgccagaaa gcugaccgug     1320

caccugagac cccccgccag cugcgaccug gagaucagcc ugagaggcgu gaagcugagc     1380

cugagcggcg gcggccccga guuccagaga ugcagccacu ucuuccagau gaagaacauc     1440

agcuucugcg gcugccaccc cagaaacagc ugcuacuucg gcuucaucac caagcacccc     1500

cugcugagca gauucgccug ccacguguuc gugagccagg agagcaugag acccguggcc     1560

cagagcgugg gcagagccuu ccuggaguac uaccaggagc accuggccua cgccugcccc     1620

accgaggaca ucuaccugga guga                                            1644


<210>  7897
<211>  1644
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG57558

<400>  7897
auggccgaca gagcugagau guucagccug uccaccuuuc acucucucag cccucccggc       60

ugccggccgc cccaggauau cucccuggaa gaguucgacg augaagaccu uucugagauu      120

acagaugacu gugggcuggg acucagcuac gauuccgacc auugcgaaaa ggauucucug      180

agccuuggcc gcuccgagca accucacccc aucuguagcu uucaggacga uuuccaggag      240

uuugaaauga uugacgauaa cgaggaagag gacgacgagg augaagagga agaggaagag      300

gaggaagagg gggacggaga aggccaggaa gggggagauc cuggcucuga ggcccccgcg      360

ccuggcccgc ugauccccuc cccuagcgug gaggagcccc auaaacacag accuacgacc      420

cuccggcuga caacccuggg ggcucaagac ucucucaaua acaauggagg cuucgaucug      480

guccgccccg ccuccuggca ggaaacagcc cuuugcagcc cggcuccuga ggcccugaga      540

gaacuccccg ggccucugcc cgcuaccgac acaggacccg gcggggccca gucuccuguu      600

cggccgggau gugauugcga gggcaaccgc cccgcggaac cucccgcccc uggcgggacc      660

ucccccagcu ccgacccggg aauugaggcu gaucuuagau cucggagcuc cggcgggcgc      720

ggaggcagac ggagcucuca ggagcugucc agcccugggu cugacagcga agaugccgga      780

ggcgcucgcc ucggcagaau gaucuccucu aucagcgaga cggaacugga gcuguccagc      840

gacgggggau cuuccagcuc uggccggucc agccaucuca ccuuuuccaa gaaauuccug      900

aauguguuug ugaacucuac aagccgcucc ucuagcaccg aguccuucgg gcuuuuuagc      960

ugucugguca auggagaaga gagagaacaa acacaccggg ccguguucag auuuauuccc     1020

cgccacccug acgagcucga acuggauguu gacgaucccg ugcuugucga ggcggaggaa     1080

gacgauuucu gguuccgggg cuuuaacaug agaaccgggg agcgcggcgu guucccugcc     1140

uuuuaugcuc augccguucc cggaccggcu aaggaccugc ucggcucuaa acgguccccu     1200

ugcugggugg aaagauucga uguccaguuu cuggggagcg uggaggugcc cugucaccag     1260

ggaaauggca uccugugcgc cgccaugcag aagauugcua cggcgcgcaa gcucacaguc     1320

caucugcggc ccccugccuc uugugaccuu gaaaucuccc ugagaggggu uaaacucagc     1380

cugucuggag gcgggccgga guuccaacgc ugcagccacu uuuuccagau gaagaacauu     1440

uccuuuugcg gcugucaccc ccggaauagc ugcuacuucg gauuuaucac caaacauccu     1500

cuucugucua gauucgcuug ucacguguuu gugucccagg agagcaugcg ccccgucgcc     1560

caauccgugg gccgggccuu ccucgaauau uaccaggagc aucuggcuua ugccugcccu     1620

acagaagaua uuuaccugga guga                                            1644


<210>  7898
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B4DGE1

<400>  7898

Met Pro Ala Pro Ile Arg Leu Arg Glu Leu Ile Arg Thr Ile Arg Thr 
1               5                   10                  15      


Ala Arg Thr Gln Ala Glu Glu Arg Glu Met Ile Gln Lys Glu Cys Ala 
            20                  25                  30          


Ala Ile Arg Ser Ser Phe Arg Glu Glu Asp Asn Thr Tyr Arg Cys Arg 
        35                  40                  45              


Asn Val Ala Lys Leu Leu Tyr Met His Met Leu Gly Tyr Pro Ala His 
    50                  55                  60                  


Phe Gly Gln Leu Glu Cys Leu Lys Leu Ile Ala Ser Gln Lys Phe Thr 
65                  70                  75                  80  


Asp Lys Arg Ile Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu Arg 
                85                  90                  95      


Gln Asp Val His Leu Leu Met Thr Asn Cys Ile Lys Asn Asp Leu Asn 
            100                 105                 110         


His Ser Thr Gln Phe Val Gln Gly Leu Ala Leu Cys Thr Leu Gly Cys 
        115                 120                 125             


Met Gly Ser Ser Glu Met Cys Arg Asp Leu Ala Gly Glu Val Glu Lys 
    130                 135                 140                 


Leu Leu Lys Thr Ser Asn Ser Tyr Leu Arg Lys Lys Glu Met Ile Tyr 
145                 150                 155                 160 


Lys Gln Thr Asn Val Thr Gly Tyr Ile Leu Gly Gly Ile Pro Asn Ser 
                165                 170                 175     






<210>  7899
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG57752

<400>  7899
augccagccc ccaucagauu gcgggagcug auccggacca uccggacagc ccgaacccaa       60

gcugaagaac gagaaaugau ccagaaagaa ugugcugcaa uccggucauc uuuuagagaa      120

gaagacaaua cauaccgaug ucggaaugug gcaaaauuac uguauaugca caugcugggc      180

uacccugcuc acuuuggaca guuggagugc cucaagcuua uugccucuca aaaauuuaca      240

gacaaacgca uuggcuauuu aggggcaaug cugcuguuag augaaagaca agauguccau      300

cuucucauga ccaacuguau caagaaugau cuuaaucaua gcacgcaauu cguacagggg      360

uuagcacuuu guacccucgg cugcaugggc uccucagaga ugugcagaga ucuugcagga      420

gagguagaga agcuccugaa aaccuccaac ucuuacuuaa gaaaaaagga aaugauuuau      480

aaacaaacaa auguuacugg auauauccua gguggcauac caaauuccua a               531


<210>  7900
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG57752

<400>  7900
augcccgccc cgauccgccu gcgggagcuc auccgcacca uccggaccgc ccgcacgcag       60

gcggaggagc gggagaugau ccagaaggag ugcgccgcca uccgcagcuc cuuccgggag      120

gaggacaaca ccuaccgcug ccggaacgug gccaagcugc uguacaugca caugcucggc      180

uaccccgccc acuucgggca gcuggagugc cugaagcuca ucgcgagcca gaaguucacc      240

gacaagcgca ucggcuaccu gggggccaug cugcuccugg acgagcggca ggacguccac      300

cuccugauga ccaacugcau caagaacgac cugaaccacu ccacgcaguu cgugcagggc      360

cuggcccucu gcacccuggg gugcaugggc agcuccgaga ugugccgcga ccuggccggc      420

gagguggaga agcuccugaa gaccagcaac uccuaccugc ggaagaagga gaugaucuac      480

aagcagacca acgucacggg guacauccuc ggcgggaucc ccaacagcug a               531


<210>  7901
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG57752

<400>  7901
augcccgccc ccauccgccu ccgcgagcuc auccgcacca uccgcaccgc ccgcacccag       60

gccgaggagc gcgagaugau ccagaaggag ugcgccgcca uccgcuccuc cuuccgcgag      120

gaggacaaca ccuaccgcug ccgcaacguc gccaagcucc ucuacaugca caugcucggc      180

uaccccgccc acuucggcca gcucgagugc cucaagcuca ucgccuccca gaaguucacc      240

gacaagcgca ucggcuaccu cggcgccaug cuccuccucg acgagcgcca ggacguccac      300

cuccucauga ccaacugcau caagaacgac cucaaccacu ccacccaguu cguccagggc      360

cucgcccucu gcacccucgg cugcaugggc uccuccgaga ugugccgcga ccucgccggc      420

gaggucgaga agcuccucaa gaccuccaac uccuaccucc gcaagaagga gaugaucuac      480

aagcagacca acgucaccgg cuacauccuc ggcggcaucc ccaacuccug a               531


<210>  7902
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG57752

<400>  7902
augccggccc cuaucagacu gagggagcuc auucggacca uacgcacagc ucgaacucag       60

gcagaggaac gugaaaugau ccaaaaggag ugcgccgcga uuagaagcuc cuucagggaa      120

gaggacaaca cguaccggug ucgcaaugug gcuaaacuuc uguauaugca cauguuggga      180

uacccagccc auuuugggca guuagagugc cugaagcuaa ucgcaucuca gaaauucacc      240

gauaagagaa uuggauaucu cggugccaug cugcuucugg acgaaaggca ggauguccac      300

uugcucauga caaacuguau caaaaaugac cugaaccauu caacucaauu uguucagggc      360

cuggcucucu gcaccuuagg guguauggga aguagcgaga ugugccggga ucuggcaggc      420

gaaguggaga aacuuuugaa gacauccaau ucuuaccugc gcaagaagga gaugauauau      480

aaacagacca acguaacugg uuacauccua gggggcauuc ccaauucgug a               531


<210>  7903
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG57752

<400>  7903
augcccgccc ccaucagacu gagagagcug aucagaacca ucagaaccgc cagaacccag       60

gccgaggaga gagagaugau ccagaaggag ugcgccgcca ucagaagcag cuucagagag      120

gaggacaaca ccuacagaug cagaaacgug gccaagcugc uguacaugca caugcugggc      180

uaccccgccc acuucggcca gcuggagugc cugaagcuga ucgccagcca gaaguucacc      240

gacaagagaa ucggcuaccu gggcgccaug cugcugcugg acgagagaca ggacgugcac      300

cugcugauga ccaacugcau caagaacgac cugaaccaca gcacccaguu cgugcagggc      360

cuggcccugu gcacccuggg cugcaugggc agcagcgaga ugugcagaga ccuggccggc      420

gagguggaga agcugcugaa gaccagcaac agcuaccuga gaaagaagga gaugaucuac      480

aagcagacca acgugaccgg cuacauccug ggcggcaucc ccaacagcug a               531


<210>  7904
<211>  531
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG57752

<400>  7904
augcccgccc cuaucagacu gcgggagcuc auucgcacca ucagaacagc ucggacgcag       60

gccgaggaac gcgaaaugau ucaaaaggag ugcgcggcua ucagaagcuc cuuccgggaa      120

gaggacaaca ccuaccgcug uagaaaugug gccaaacugc uuuauaugca caugcugggc      180

uacccggccc auuuugggca gcucgagugc cugaaacuua uugcuucuca gaaguucaca      240

gauaagcgga ucggauaucu gggcgccaug cuccugcugg acgaacgcca ggauguccac      300

cuccugauga ccaacuguau caaaaaugac cuuaaccaua gcacacaauu uguucagggg      360

cuggcucucu gcacccuggg auguaugggc uccucugaga ugugcagaga ucuugccggg      420

gaaguggaga agcugcucaa gacaagcaau uccuaccugc ggaaaaagga gaugauuuau      480

aaacagacca acgugacggg auacauccug ggcggcauuc ccaauucuug a               531


<210>  7905
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B4DJ64

<400>  7905

Met Ala Pro Pro Gly Gly Pro Pro Ala Ala Pro Pro Gly Gly Arg Gly 
1               5                   10                  15      


His Ser His Arg Asp Arg Ile His Tyr Gln Ala Asp Val Arg Leu Glu 
            20                  25                  30          


Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg Pro Pro Asp Ala 
        35                  40                  45              


Ala Glu Pro Thr Ser Ala Phe Leu Pro Pro Thr Glu Ser Arg Met Ser 
    50                  55                  60                  


Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Pro Ser Thr Ala Gly Arg 
65                  70                  75                  80  


Pro His Pro Ser Ile Ser Glu Glu Glu Glu Gly Phe Asp Cys Leu Ser 
                85                  90                  95      


Ser Pro Glu Arg Ala Glu Pro Pro Gly Gly Gly Trp Arg Gly Ser Leu 
            100                 105                 110         


Gly Glu Pro Pro Pro Pro Pro Arg Ala Ser Leu Ser Ser Asp Thr Ser 
        115                 120                 125             


Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val Val Asp Glu His 
    130                 135                 140                 


Ala Gln Leu Glu Leu Val Ser Leu Arg Pro Cys Phe Gly Asp Tyr Ser 
145                 150                 155                 160 


Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys Ala Ser Val Ser 
                165                 170                 175     


Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu Glu Ala Pro Arg 
            180                 185                 190         


Pro Gln Pro Pro Ala Cys Leu Ser Glu Asp Ser Thr Pro Asp Glu Pro 
        195                 200                 205             


Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe Met Ser Gly Arg 
    210                 215                 220                 


Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe Ser Cys Ile Ile 
225                 230                 235                 240 


Asn Gly Glu Glu Gln Glu Gln Thr His Arg Ala Ile Phe Arg Phe Val 
                245                 250                 255     


Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp Asp Pro Leu Leu 
            260                 265                 270         


Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala Tyr Asn Met Arg 
        275                 280                 285             


Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala Ile Glu Val Thr 
    290                 295                 300                 


Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn Ser Asp Trp Val 
305                 310                 315                 320 


Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln Val Pro Tyr His 
                325                 330                 335     


Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys Ile Ala Thr Thr 
            340                 345                 350         


Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser Cys Val Leu Glu 
        355                 360                 365             


Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys Ala Asp Asp Ser Gln 
    370                 375                 380                 


Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln Leu Lys Asn Ile 
385                 390                 395                 400 


Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr Phe Gly Phe Ile 
                405                 410                 415     


Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His Val Phe Val Ser 
            420                 425                 430         


Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly Arg Ala Phe Gln 
        435                 440                 445             


Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro Thr Glu Asp Ile 
    450                 455                 460                 


Tyr Leu Glu 
465         


<210>  7906
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG58726

<400>  7906
auggcaccuc cggguggucc cccugcugcc ccgccugggg gucggggcca cucgcaucga       60

gaccgaaucc acuaccaggc cgaugugcga cuagaggcca cugaggagau cuaccugacc      120

ccagugcaga ggcccccaga cgcugcagag cccaccuccg ccuuccugcc gcccacugag      180

agccggaugu cagucagcuc cgauccagac ccugccgccu accccuccac ggcagggcgg      240

ccgcaccccu ccaucaguga agaggaagag ggcuucgacu gccugucguc cccagagcgg      300

gcugagcccc caggcggagg guggcggggg agccuggggg agccgccgcc accuccacgg      360

gccucucuga gcucggacac cagcgcccug uccuaugacu cugucaagua cacgcuggug      420

guagaugagc augcacagcu ggagcuggug agccugcggc cgugcuucgg agacuacagu      480

gacgagagug acucugccac cgucuaugac aacugugccu ccgucuccuc gcccuaugag      540

ucggccaucg gagaggaaua ugaggaggcc ccgcggcccc agcccccugc cugccucucc      600

gaggacucca cgccugauga acccgacguc cauuucucca agaaauuccu gaacgucuuc      660

augaguggcc gcucccgcuc cuccagugcu gaguccuucg ggcuguucuc cugcaucauc      720

aacggggagg agcaggagca gacccaccgg gccauauuca gguuugugcc ucgacacgaa      780

gacgaacuug agcuggaagu ggaugacccu cugcuagugg agcuccaggc ugaagacuac      840

ugguacgagg ccuacaacau gcgcacuggu gcccggggug ucuuuccugc cuauuacgcc      900

aucgagguca ccaaggagcc cgagcacaug gcagcccugg ccaaaaacag ugacugggug      960

gaccaguucc gggugaaguu ccugggcuca guccagguuc ccuaucacaa gggcaaugac     1020

guccucugug cugcuaugca aaagauugcc accacccgcc ggcucaccgu gcacuuuaac     1080

ccgcccucca gcuguguccu ggagaucagc gugcggggug ugaagauagg cgucaaggcc     1140

gaugacuccc aggaggccaa ggggaauaaa uguagccacu uuuuccaguu aaaaaacauc     1200

ucuuucugcg gauaucaucc aaagaacaac aaguacuuug gguucaucac caagcacccc     1260

gccgaccacc gguuugccug ccacgucuuu gugucugaag acuccaccaa agcccuggca     1320

gaguccgugg ggagagcauu ccagcaguuc uacaagcagu uuguggagua caccugcccc     1380

acagaagaua ucuaccugga guag                                            1404


<210>  7907
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG58726

<400>  7907
auggccccgc ccggcgggcc gcccgccgcg ccgcccggcg ggcgcggcca cagccaccgg       60

gaccgcaucc acuaccaggc cgacgugcgg cuggaggcca ccgaggagau cuaccucacc      120

cccguccagc gcccgcccga cgccgccgag cccacguccg cguuccugcc gcccaccgag      180

agccggaugu ccgugagcuc cgaccccgac cccgccgccu accccagcac cgccgggcgc      240

ccccaccccu ccaucagcga ggaggaggag ggcuucgacu gccuguccag ccccgagcgg      300

gcggagccgc ccggcggggg cuggcgcggg ucccucggcg agcccccgcc cccgccccgg      360

gccagccugu ccagcgacac cuccgcccug agcuacgacu ccgugaagua cacgcucguc      420

guggacgagc acgcccagcu ggagcuggug agccuccgcc ccugcuucgg ggacuacucc      480

gacgagagcg acagcgccac cgucuacgac aacugcgcgu ccgugagcuc ccccuacgag      540

agcgccaucg gcgaggagua cgaggaggcg ccccggcccc agccgcccgc cugccugucc      600

gaggacagca cccccgacga gcccgacgug cacuucucca agaaguuccu gaacgucuuc      660

augagcggcc gcucccggag cuccagcgcc gaguccuucg gccucuucag cugcaucauc      720

aacggggagg agcaggagca gacccaccgc gccaucuucc gguucgugcc ccgccacgag      780

gacgagcugg agcuggaggu ggacgacccc cuccuggucg agcugcaggc cgaggacuac      840

ugguacgagg ccuacaacau gcggacgggg gcccgcggcg uguuccccgc cuacuacgcg      900

aucgagguga ccaaggagcc ggagcacaug gccgcccucg ccaagaacuc cgacuggguc      960

gaccaguucc gggugaaguu ccugggcagc gugcaggucc ccuaccacaa ggggaacgac     1020

gugcugugcg ccgcgaugca gaagaucgcc accacccgcc ggcucacggu gcacuucaac     1080

ccgcccucca gcugcguccu ggagaucucc gugcgcggcg ugaagaucgg ggucaaggcc     1140

gacgacagcc aggaggccaa gggcaacaag ugcagccacu ucuuccagcu gaagaacauc     1200

uccuucugcg gguaccaccc caagaacaac aaguacuucg gcuucaucac caagcacccc     1260

gcggaccacc gcuucgccug ccacguguuc gucagcgagg acuccaccaa ggcccucgcc     1320

gagagcgugg gccgggccuu ccagcaguuc uacaagcagu ucguggagua cacgugcccc     1380

accgaggaca ucuaccugga guga                                            1404


<210>  7908
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG58726

<400>  7908
auggcccccc ccggcggccc ccccgccgcc ccccccggcg gccgcggcca cucccaccgc       60

gaccgcaucc acuaccaggc cgacguccgc cucgaggcca ccgaggagau cuaccucacc      120

cccguccagc gcccccccga cgccgccgag cccaccuccg ccuuccuccc ccccaccgag      180

ucccgcaugu ccgucuccuc cgaccccgac cccgccgccu accccuccac cgccggccgc      240

ccccaccccu ccaucuccga ggaggaggag ggcuucgacu gccucuccuc ccccgagcgc      300

gccgagcccc ccggcggcgg cuggcgcggc ucccucggcg agcccccccc ccccccccgc      360

gccucccucu ccuccgacac cuccgcccuc uccuacgacu ccgucaagua cacccucguc      420

gucgacgagc acgcccagcu cgagcucguc ucccuccgcc ccugcuucgg cgacuacucc      480

gacgaguccg acuccgccac cgucuacgac aacugcgccu ccgucuccuc ccccuacgag      540

uccgccaucg gcgaggagua cgaggaggcc ccccgccccc agccccccgc cugccucucc      600

gaggacucca cccccgacga gcccgacguc cacuucucca agaaguuccu caacgucuuc      660

auguccggcc gcucccgcuc cuccuccgcc gaguccuucg gccucuucuc cugcaucauc      720

aacggcgagg agcaggagca gacccaccgc gccaucuucc gcuucguccc ccgccacgag      780

gacgagcucg agcucgaggu cgacgacccc cuccucgucg agcuccaggc cgaggacuac      840

ugguacgagg ccuacaacau gcgcaccggc gcccgcggcg ucuuccccgc cuacuacgcc      900

aucgagguca ccaaggagcc cgagcacaug gccgcccucg ccaagaacuc cgacuggguc      960

gaccaguucc gcgucaaguu ccucggcucc guccaggucc ccuaccacaa gggcaacgac     1020

guccucugcg ccgccaugca gaagaucgcc accacccgcc gccucaccgu ccacuucaac     1080

ccccccuccu ccugcguccu cgagaucucc guccgcggcg ucaagaucgg cgucaaggcc     1140

gacgacuccc aggaggccaa gggcaacaag ugcucccacu ucuuccagcu caagaacauc     1200

uccuucugcg gcuaccaccc caagaacaac aaguacuucg gcuucaucac caagcacccc     1260

gccgaccacc gcuucgccug ccacgucuuc gucuccgagg acuccaccaa ggcccucgcc     1320

gaguccgucg gccgcgccuu ccagcaguuc uacaagcagu ucgucgagua caccugcccc     1380

accgaggaca ucuaccucga guga                                            1404


<210>  7909
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG58726

<400>  7909
auggcucccc cuggcgggcc accggccgca cccccuggag guagaggcca cagccauagg       60

gaccggaucc acuaccaggc cgaugugcgc cuggaggcga ccgaagagau uuaucucaca      120

ccaguccaac gacccccuga cgcugccgaa ccaacuuccg cauuccuucc cccuacggag      180

ucucguaugu caguuaguag cgauccagac ccggccgcuu accccuccac cgcagggaga      240

ccucauccau cuauaucgga agaggaggaa ggauuugauu gccugucaag ccccgagagg      300

gccgaaccuc caggcggugg guggcgggga aguuugggcg agcccccgcc ucccccacgc      360

gcuuccuuau cuagcgacac auccgcccug ucauaugaua gugugaagua cacucuagua      420

guggacgagc acgcgcagcu cgaacugguc agccuuagac cuuguuucgg cgauuauucu      480

gacgaguccg auucagcaac cguguacgac aacugcgcca gcguuaguuc ucccuaugaa      540

uccgcuaucg gggaggaaua cgaggaggcc ccaaggcccc agccuccagc augucugagc      600

gaagauucga caccggacga gcccgacgug cauuuuucua aaaaguucuu gaaugucuuu      660

auguccggac ggucacgcag uagcuccgcu gaaucuuucg gucucuuuag cugcauuauc      720

aacggcgagg aacaggagca aacccaccga gccauuuuca gauuugugcc uaggcacgag      780

gaugaacugg agcuggaagu agacgaucca cucuuaguug agcugcaggc ggaagacuac      840

ugguaugagg ccuacaauau gcggacuggg gcacguggag uguuccccgc uuauuacgcc      900

aucgagguca caaaagaacc ugagcauaug gcugcccuug caaagaacuc agauugggug      960

gaccaguuuc gcgugaaauu cuugggcagu guccagguuc cauaucacaa ggguaaugau     1020

gugcugugug ccgcuaugca aaagauagcg accacgagaa ggcuaacugu acauuuuaau     1080

cccccgucca gcugcgugcu cgaaaucucu guccgagggg ugaaaauugg aguuaaggca     1140

gacgauucac aggaggccaa aggcaacaag uguagucacu ucuuccagcu gaaaaacauc     1200

agcuuuugcg gcuaccaccc uaagaauaac aaguauuucg gguuuauuac caaacaucca     1260

gcugaccacc gguucgccug ucauguguuu gucuccgagg auucuacaaa ggcacuugcc     1320

gaaucggugg gacgcgcuuu ccagcaauuu uacaaacagu ucguagagua cacuugcccc     1380

accgaagaca ucuaucugga guga                                            1404


<210>  7910
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG58726

<400>  7910
auggcccccc ccggcggccc ccccgccgcc ccccccggcg gcagaggcca cagccacaga       60

gacagaaucc acuaccaggc cgacgugaga cuggaggcca ccgaggagau cuaccugacc      120

cccgugcaga gaccccccga cgccgccgag cccaccagcg ccuuccugcc ccccaccgag      180

agcagaauga gcgugagcag cgaccccgac cccgccgccu accccagcac cgccggcaga      240

ccccacccca gcaucagcga ggaggaggag ggcuucgacu gccugagcag ccccgagaga      300

gccgagcccc ccggcggcgg cuggagaggc agccugggcg agcccccccc cccccccaga      360

gccagccuga gcagcgacac cagcgcccug agcuacgaca gcgugaagua cacccuggug      420

guggacgagc acgcccagcu ggagcuggug agccugagac ccugcuucgg cgacuacagc      480

gacgagagcg acagcgccac cguguacgac aacugcgcca gcgugagcag ccccuacgag      540

agcgccaucg gcgaggagua cgaggaggcc cccagacccc agccccccgc cugccugagc      600

gaggacagca cccccgacga gcccgacgug cacuucagca agaaguuccu gaacguguuc      660

augagcggca gaagcagaag cagcagcgcc gagagcuucg gccuguucag cugcaucauc      720

aacggcgagg agcaggagca gacccacaga gccaucuuca gauucgugcc cagacacgag      780

gacgagcugg agcuggaggu ggacgacccc cugcuggugg agcugcaggc cgaggacuac      840

ugguacgagg ccuacaacau gagaaccggc gccagaggcg uguuccccgc cuacuacgcc      900

aucgagguga ccaaggagcc cgagcacaug gccgcccugg ccaagaacag cgacugggug      960

gaccaguuca gagugaaguu ccugggcagc gugcaggugc ccuaccacaa gggcaacgac     1020

gugcugugcg ccgccaugca gaagaucgcc accaccagaa gacugaccgu gcacuucaac     1080

ccccccagca gcugcgugcu ggagaucagc gugagaggcg ugaagaucgg cgugaaggcc     1140

gacgacagcc aggaggccaa gggcaacaag ugcagccacu ucuuccagcu gaagaacauc     1200

agcuucugcg gcuaccaccc caagaacaac aaguacuucg gcuucaucac caagcacccc     1260

gccgaccaca gauucgccug ccacguguuc gugagcgagg acagcaccaa ggcccuggcc     1320

gagagcgugg gcagagccuu ccagcaguuc uacaagcagu ucguggagua caccugcccc     1380

accgaggaca ucuaccugga guga                                            1404


<210>  7911
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG58726

<400>  7911
auggcucccc cuggcgggcc gcccgccgcc ccucccggag gcagagggca cagccaucgg       60

gaccgcaucc acuaccaggc ggaugugaga cuggaggcua ccgaagagau uuaucucaca      120

ccuguccaac ggcccccuga cgccgccgaa ccgacguccg cuuuccugcc cccuaccgag      180

ucucgcauga gcguuuccuc ugaucccgac ccugccgcuu accccagcac agccggaaga      240

ccgcauccuu ccaucucuga agaggaggaa ggcuuugauu gccuuagcuc ccccgagcgg      300

gcggaaccuc ccgggggagg cuggcgcggc agccuggggg agcccccucc gcccccuaga      360

gccucucucu ccagcgacac cucugcucug uccuaugaua gcgugaagua cacacuugug      420

gucgacgagc acgcccagcu ggaacucgug ucucugcggc ccuguuucgg agauuauucc      480

gacgagagcg auuccgcuac cguuuacgac aacugcgccu cugugagcuc cccuuaugaa      540

agcgcgauug gcgaggaaua cgaggaggcu ccccgcccgc agccucccgc cugucugucu      600

gaagauucca caccugacga gcccgacguc cauuuuagca aaaaguuccu caauguguuu      660

augucuggga gaagccgguc cucuagcgcc gaauccuucg gacuguuuag cugcaucauu      720

aacggcgagg aacaggagca aacccaccgc gcuaucuuca gauuuguucc ucggcacgag      780

gaugaacuug agcuggaagu ggacgauccc cuccuggucg agcuucaggc cgaagacuac      840

ugguaugagg ccuacaauau gcgcacgggg gcuagaggag uguucccggc guauuacgcc      900

aucgagguga ccaaagaacc ugagcauaug gcugcccugg ccaagaacuc ugauuggguc      960

gaccaguuuc ggguuaaauu ccucggcucc guccaggugc ccuaucacaa gggcaaugau     1020

gugcugugug cugccaugca aaagauugcg acaaccagac gccugacagu gcauuuuaau     1080

cccccuagcu cuugcguucu cgaaaucucc gugagagggg ucaaaauugg agugaaggcu     1140

gacgauagcc aggaggccaa aggcaacaag uguucccacu ucuuccagcu gaaaaacauc     1200

ucuuuuugcg gguaccaccc gaagaauaac aaguauuucg gauuuauuac caaacauccc     1260

gccgaccacc gguucgcuug ucauguuuuu gugagcgagg auuccacgaa ggcccuugcu     1320

gaaucugucg gccgcgccuu ccagcaauuu uacaaacagu ucguggagua cacaugcccu     1380

accgaagaca ucuaucugga guga                                            1404


<210>  7912
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B4DS36

<400>  7912

Met Val Met Arg Trp Gly Glu Arg Asn Asp Val Ile Ala Trp Glu Leu 
1               5                   10                  15      


Leu Gln Asp Gly Val Glu Thr Lys Asn Ala Leu Asn Ile Val Lys Asn 
            20                  25                  30          


Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp Val Leu 
        35                  40                  45              


Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu Glu Glu 
    50                  55                  60                  


Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala Glu Thr 
65                  70                  75                  80  


Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp Ile Pro 
                85                  90                  95      


Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg Val Leu 
            100                 105                 110         


Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln Glu Ala 
        115                 120                 125             


Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro Ala Met 
    130                 135                 140                 


Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg Leu Phe 
145                 150                 155                 160 


Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val Asn Leu 
                165                 170                 175     


Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys Lys Arg 
            180                 185                 190         


Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala Phe Asp 
        195                 200                 205             


Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg Glu Gln 
    210                 215                 220                 


Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys Glu Asp 
225                 230                 235                 240 


Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr Lys Gln 
                245                 250                 255     


Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro Val Pro 
            260                 265                 270         


Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met Lys Leu Trp 
        275                 280                 285             


Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp Gly Gly 
    290                 295                 300                 


Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly Leu Asp 
305                 310                 315                 320 


Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu Asp Lys 
                325                 330                 335     


Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn Gln Glu 
            340                 345                 350         


Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser Ala Thr 
        355                 360                 365             


Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu Asp Ser 
    370                 375                 380                 


Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val Pro Gly 
385                 390                 395                 400 


Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu Ser Gly 
                405                 410                 415     


Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn Ser Ser 
            420                 425                 430         


Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly Cys Ser 
        435                 440                 445             


Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn Gly Ala 
    450                 455                 460                 


Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn Ser Glu 
465                 470                 475                 480 


Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala Thr Glu 
                485                 490                 495     


Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln Thr Gly 
            500                 505                 510         


Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln Ile Pro 
        515                 520                 525             


Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp Ala Tyr 
    530                 535                 540                 


Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val Arg Glu 
545                 550                 555                 560 


Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu Gly Ala 
                565                 570                 575     


Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp Arg Lys 
            580                 585                 590         


Cys Leu His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser Ile Val His 
        595                 600                 605             


Val Lys Gly Ile Val Leu Val Ala Leu Ala Asp Gly Thr Leu Ala Ile 
    610                 615                 620                 


Phe His Arg Gly Val Asp Gly Gln Trp Asp Leu Ser Asn Tyr His Leu 
625                 630                 635                 640 


Leu Asp Leu Gly Arg Pro His His Ser Ile Arg Cys Met Thr Val Val 
                645                 650                 655     


His Asp Lys Val Trp Cys Gly Tyr Arg Asn Lys Ile Tyr Val Val Gln 
            660                 665                 670         


Pro Lys Ala Met Lys Ile Glu Lys Ser Phe Asp Ala His Pro Arg Lys 
        675                 680                 685             


Glu Ser Gln Val Arg Gln Leu Ala Trp Val Gly Asp Gly Val Trp Val 
    690                 695                 700                 


Ser Ile Arg Leu Asp Ser Thr Leu Arg Leu Tyr His Ala His Thr Tyr 
705                 710                 715                 720 


Gln His Leu Gln Asp Val Asp Ile Glu Pro Tyr Val Ser Lys Met Leu 
                725                 730                 735     


Gly Thr Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala Leu Met 
            740                 745                 750         


Val Ser Cys Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val Ile Ile 
        755                 760                 765             


Ser Ile Pro Leu Thr Glu Thr Asn Lys Thr Ser Gly Val Pro Gly Asn 
    770                 775                 780                 


Arg Pro Gly Ser Val Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys 
785                 790                 795                 800 


Val Thr Pro Gly Thr Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln 
                805                 810                 815     


Leu Cys Phe His Gly His Arg Asp Ala Val Lys Phe Phe Val Ala Val 
            820                 825                 830         


Pro Gly Gln Val Ile Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu 
        835                 840                 845             


Thr Gly Asp Lys Ala Gly Pro Ser Ala Gln Glu Pro Gly Ser Gln Thr 
    850                 855                 860                 


Pro Leu Lys Ser Met Leu Val Ile Ser Gly Gly Glu Gly Tyr Ile Asp 
865                 870                 875                 880 


Phe Arg Met Gly Asp Glu Gly Gly Glu Ser Glu Leu Leu Gly Glu Asp 
                885                 890                 895     


Leu Pro Leu Glu Pro Ser Ile Thr Lys Ala Glu Arg Ser His Leu Ile 
            900                 905                 910         


Val Trp Gln Val Met Tyr Gly Asn Glu 
        915                 920     


<210>  7913
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAG61498

<400>  7913
augguuauga gguggggaga acggaaugac gucaucgcuu gggagcugcu gcaggaugga       60

guggaaacca aaaaugcuuu gaacauagug aagaaugauu ugauagcaaa aguggaugaa      120

cugaccugug agaaagaugu gcugcaaggg gaauuggagg cugugaagca agccaaacug      180

aaacuagagg aaaagaacag agaauuggag gaagagcuua ggaaagcucg ggcagaaacu      240

gaagaugcaa ggcaaaaagc aaaagaugac gaugauagug auauucccac agcccagagg      300

aagcgguuua cuagaguaga aauggcccgu guucucaugg agcgaaacca guauaaagag      360

agauugaugg agcuucagga agcuguucga uggacagaga ugauucgggc aucacgagaa      420

aauccagcca ugcaggaaaa aaaaagguca agcauuuggc aguuuuucag ccgacuuuuc      480

agcuccucaa guaacacgac uaagaagccu gaaccaccug uuaaucugaa guacaaugca      540

cccacgucuc auguuacucc guccgucaag aaaagaagca gcaccuuauc ucagcucccu      600

ggggauaagu ccaaagccuu ugauuuccuu agugaagaaa cugaagcuag uuuagccuca      660

cgcagagaac aaaagagaga gcaguaucgu cagguaaaag cacauguuca gaaggaagac      720

gguagagugc aggcuuuugg cuggagucug ccucagaagu acaaacaggu aaccaauggu      780

caaggcgaaa auaagaugaa aaauuuaccu gugccugucu aucucagacc ucuggaugaa      840

aaagauacau caaugaagcu guggugugcu guuggaguca auuuaucugg ugggaagacc      900

agagauggug guucuguugu uggagcaagu guauuuuaca aggauguugc ugguuuggau      960

acagaaggca guaaacagcg aagugccucu cagaguaguu uagauaaguu agaucaggaa     1020

cuuaaggaac agcagaagga guuaaaaaau caagaagaau uauccagucu aguuuggauc     1080

uguaccagca cucauucggc uacaaaaguu cuuauuauug augcuguuca accuggcaac     1140

auccuagaca guuucacugu uugcaacucu cauguucugu gcauugcaag ugugccaggu     1200

gcacgagaaa cagacuaccc ugcaggagaa gaucuuucag aaucugguca gguagacaaa     1260

gcaucuuuau guggaaguau gacaagcaac agcucagcag agacagacag ccuguuagga     1320

ggcaucacag ugguugguug uucugcagaa ggugugacgg gagcugccac uuccccuagu     1380

acaaauggug cuucuccagu gauggauaaa ccaccagaaa uggaagcaga aaauagugag     1440

guugaugaaa auguuccaac agcagaagaa gcaacugaag cuacagaagg gaaugcgggg     1500

ucagcugaag acacagugga caucucccaa acuggcgucu acacagagca ugucuuuaca     1560

gauccuuugg gaguucagau cccagaagac cucuccccag uguaucaguc gagcaaugac     1620

ucagaugcau auaaagauca aauaucagua cugccaaaug aacaagacuu ggugagagaa     1680

gaagcccaga aaaugaguag ucuuuuacca acuauguggc uuggagcuca aaauggcugu     1740

uuguaugucc auucaucugu agcccagugg aggaaauguc uccauuccau uaaacuuaaa     1800

gauucgauuc ucaguauugu acacgugaag ggaaucgugu uaguagcccu ggcugacggc     1860

acccuugcaa ucuuucacag aggaguggau gggcaguggg auuugucaaa cuaucaccuc     1920

uuagaccuug gacggccuca ucauuccauc cguugcauga cugugguaca ugacaaaguc     1980

ugguguggcu auaggaacaa aaucuaugug gugcagccaa aggccaugaa aauagagaaa     2040

ucuuuugaug cacaucccag gaaggagagc caagugcgac agcuugcgug ggugggggau     2100

ggcguguggg ucuccauucg cuuggauucu acgcuccguc ucuaucaugc acacacuuau     2160

caacaucuac aggaugugga cauugagccu uauguaagca aaauguuagg uacuggaaaa     2220

cugggcuucu cuuuugugag aauuacagcu cuuauggugu cuuguaaucg uuugugggug     2280

gggacaggaa auggugucau uaucuccauc ccauugacag aaacaaauaa aaccucaggu     2340

guaccaggaa aucguccugg aaguguaauc cguguauaug gugaugaaaa cagugauaaa     2400

gugacuccag ggacauuuau acccuauugu ucaauggcac augcacagcu uugcuuccau     2460

gggcaccggg augcugugaa auucuuugug gcagucccag gucaagucau cagcccacaa     2520

aguagcagua guggcacgga ucugacgggu gacaaagcag ggccaucugc acaggagccu     2580

gguagucaga cgcccuugaa gucuaugcuu gucaucagug gaggagaggg cuacaucgac     2640

uuccgaaugg gugaugaagg uggagaauca gaacuucuug gagaggaucu uccucuugaa     2700

ccuucuauca ccaaagcaga aaggagucac uugauagugu ggcaagugau guauggcaau     2760

gaguga                                                                2766


<210>  7914
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAG61498

<400>  7914
auggugaugc gcuggggcga gcggaacgac gugaucgccu gggagcugcu ccaggacggg       60

guggagacca agaacgcccu gaacaucgug aagaacgacc ugaucgcgaa ggucgacgag      120

cugaccugcg agaaggacgu gcugcagggc gagcuggagg ccgugaagca ggccaagcuc      180

aagcuggagg agaagaaccg cgagcuggag gaggagcucc ggaaggcccg cgccgagacc      240

gaggacgcgc ggcagaaggc caaggacgac gacgacagcg acauccccac cgcccagcgc      300

aagcgguuca cccgcgucga gauggcccgg gugcugaugg agcgcaacca guacaaggag      360

cggcugaugg agcuccagga ggcggugcgc uggaccgaga ugauccgggc cucccgcgag      420

aacccggcca ugcaggagaa gaagcggagc uccaucuggc aguucuucag ccgccuguuc      480

uccagcucca gcaacacgac caagaagccc gagccgcccg ucaaccugaa guacaacgcc      540

cccaccuccc acgugacccc cagcgugaag aagcggucca gcacgcucuc ccagcugccc      600

ggggacaaga gcaaggccuu cgacuuccug uccgaggaga ccgaggcgag ccucgccucc      660

cgccgggagc agaagcgcga gcaguaccgg caggucaagg cccacgugca gaaggaggac      720

ggccgcgugc aggccuucgg guggagccug ccccagaagu acaagcaggu caccaacggc      780

cagggcgaga acaagaugaa gaaccugccg gugcccgugu accuccgccc ccuggacgag      840

aaggacaccu ccaugaagcu guggugcgcc gucgggguga accucagcgg cgggaagacg      900

cgggacggcg ggagcguggu cggcgcgucc guguucuaca aggacguggc cggccuggac      960

accgagggga gcaagcagcg cuccgccagc caguccagcc uggacaagcu cgaccaggag     1020

cugaaggagc agcagaagga gcugaagaac caggaggagc ucuccagccu ggucuggauc     1080

ugcaccucca cccacagcgc cacgaaggug cugaucaucg acgccgucca gcccggcaac     1140

auccucgacu ccuucaccgu gugcaacagc cacgugcugu gcaucgcguc cgucccgggg     1200

gcccgggaga ccgacuaccc cgccggcgag gaccugagcg aguccggcca gguggacaag     1260

gccagccucu gcggguccau gaccagcaac uccagcgccg agacggacag ccugcugggc     1320

gggaucaccg uggucggcug cuccgcggag ggggugaccg gcgccgccac cagccccucc     1380

acgaacggcg ccagccccgu gauggacaag ccgcccgaga uggaggcgga gaacuccgag     1440

gucgacgaga acgugcccac cgccgaggag gccaccgagg ccaccgaggg gaacgccggc     1500

agcgcggagg acacggugga caucucccag accggggucu acaccgagca cguguucacc     1560

gacccccucg gcgugcagau cccggaggac cugagccccg ucuaccaguc cagcaacgac     1620

uccgacgccu acaaggacca gaucagcgug cugcccaacg agcaggaccu cgugcgcgag     1680

gaggcccaga agauguccag ccugcugccc acgauguggc ucggggccca gaacggcugc     1740

cuguacgucc acuccagcgu ggcccagugg cggaagugcc ugcacuccau caagcucaag     1800

gacagcaucc ugagcaucgu gcacgucaag ggcaucgugc ugguggcgcu ggccgacggg     1860

acccucgcca ucuuccaccg cggcgucgac gggcaguggg accuguccaa cuaccaccuc     1920

cucgaccugg gccggccgca ccacagcauc cgcugcauga ccguggugca cgacaagguc     1980

uggugcgggu accggaacaa gaucuacgug gugcagccca aggccaugaa gaucgagaag     2040

uccuucgacg cccacccccg caaggagagc cagguccggc agcuggcgug ggugggcgac     2100

ggcguguggg ucuccauccg ccucgacagc acccugcggc uguaccacgc ccacacguac     2160

cagcaccucc aggacgugga caucgagccc uacgugucca agaugcuggg gaccggcaag     2220

cugggguuca gcuucguccg caucaccgcc cucauggugu ccugcaaccg gcugugggug     2280

ggcaccggca acggggucau caucagcauc ccgcugaccg agacgaacaa gaccuccggc     2340

gugcccggga accgccccgg cagcgugauc cgggucuacg gggacgagaa cuccgacaag     2400

gugaccccgg gcaccuucau ccccuacugc agcauggccc acgcgcagcu cugcuuccac     2460

ggccaccgcg acgccgugaa guucuucguc gccgugcccg gccaggugau cagcccccag     2520

uccuccagcu ccgggacgga ccugaccggg gacaaggccg gcccgagcgc ccaggagccc     2580

gggagccaga cgccccugaa guccaugcuc gucaucagcg gcggcgaggg guacaucgac     2640

uuccggaugg gcgacgaggg cggggagucc gagcugcugg gggaggaccu cccccuggag     2700

ccgagcauca ccaaggcgga gcgcucccac cugaucgugu ggcaggucau guacggcaac     2760

gaguga                                                                2766


<210>  7915
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAG61498

<400>  7915
auggucaugc gcuggggcga gcgcaacgac gucaucgccu gggagcuccu ccaggacggc       60

gucgagacca agaacgcccu caacaucguc aagaacgacc ucaucgccaa ggucgacgag      120

cucaccugcg agaaggacgu ccuccagggc gagcucgagg ccgucaagca ggccaagcuc      180

aagcucgagg agaagaaccg cgagcucgag gaggagcucc gcaaggcccg cgccgagacc      240

gaggacgccc gccagaaggc caaggacgac gacgacuccg acauccccac cgcccagcgc      300

aagcgcuuca cccgcgucga gauggcccgc guccucaugg agcgcaacca guacaaggag      360

cgccucaugg agcuccagga ggccguccgc uggaccgaga ugauccgcgc cucccgcgag      420

aaccccgcca ugcaggagaa gaagcgcucc uccaucuggc aguucuucuc ccgccucuuc      480

uccuccuccu ccaacaccac caagaagccc gagccccccg ucaaccucaa guacaacgcc      540

cccaccuccc acgucacccc cuccgucaag aagcgcuccu ccacccucuc ccagcucccc      600

ggcgacaagu ccaaggccuu cgacuuccuc uccgaggaga ccgaggccuc ccucgccucc      660

cgccgcgagc agaagcgcga gcaguaccgc caggucaagg cccacgucca gaaggaggac      720

ggccgcgucc aggccuucgg cuggucccuc ccccagaagu acaagcaggu caccaacggc      780

cagggcgaga acaagaugaa gaaccucccc guccccgucu accuccgccc ccucgacgag      840

aaggacaccu ccaugaagcu cuggugcgcc gucggcguca accucuccgg cggcaagacc      900

cgcgacggcg gcuccgucgu cggcgccucc gucuucuaca aggacgucgc cggccucgac      960

accgagggcu ccaagcagcg cuccgccucc caguccuccc ucgacaagcu cgaccaggag     1020

cucaaggagc agcagaagga gcucaagaac caggaggagc ucuccucccu cgucuggauc     1080

ugcaccucca cccacuccgc caccaagguc cucaucaucg acgccgucca gcccggcaac     1140

auccucgacu ccuucaccgu cugcaacucc cacguccucu gcaucgccuc cguccccggc     1200

gcccgcgaga ccgacuaccc cgccggcgag gaccucuccg aguccggcca ggucgacaag     1260

gccucccucu gcggcuccau gaccuccaac uccuccgccg agaccgacuc ccuccucggc     1320

ggcaucaccg ucgucggcug cuccgccgag ggcgucaccg gcgccgccac cucccccucc     1380

accaacggcg ccucccccgu cauggacaag ccccccgaga uggaggccga gaacuccgag     1440

gucgacgaga acguccccac cgccgaggag gccaccgagg ccaccgaggg caacgccggc     1500

uccgccgagg acaccgucga caucucccag accggcgucu acaccgagca cgucuucacc     1560

gacccccucg gcguccagau ccccgaggac cucucccccg ucuaccaguc cuccaacgac     1620

uccgacgccu acaaggacca gaucuccguc cuccccaacg agcaggaccu cguccgcgag     1680

gaggcccaga agauguccuc ccuccucccc accauguggc ucggcgccca gaacggcugc     1740

cucuacgucc acuccuccgu cgcccagugg cgcaagugcc uccacuccau caagcucaag     1800

gacuccaucc ucuccaucgu ccacgucaag ggcaucgucc ucgucgcccu cgccgacggc     1860

acccucgcca ucuuccaccg cggcgucgac ggccaguggg accucuccaa cuaccaccuc     1920

cucgaccucg gccgccccca ccacuccauc cgcugcauga ccgucgucca cgacaagguc     1980

uggugcggcu accgcaacaa gaucuacguc guccagccca aggccaugaa gaucgagaag     2040

uccuucgacg cccacccccg caaggagucc cagguccgcc agcucgccug ggucggcgac     2100

ggcgucuggg ucuccauccg ccucgacucc acccuccgcc ucuaccacgc ccacaccuac     2160

cagcaccucc aggacgucga caucgagccc uacgucucca agaugcucgg caccggcaag     2220

cucggcuucu ccuucguccg caucaccgcc cucauggucu ccugcaaccg ccucuggguc     2280

ggcaccggca acggcgucau caucuccauc ccccucaccg agaccaacaa gaccuccggc     2340

guccccggca accgccccgg cuccgucauc cgcgucuacg gcgacgagaa cuccgacaag     2400

gucacccccg gcaccuucau ccccuacugc uccauggccc acgcccagcu cugcuuccac     2460

ggccaccgcg acgccgucaa guucuucguc gccguccccg gccaggucau cuccccccag     2520

uccuccuccu ccggcaccga ccucaccggc gacaaggccg gccccuccgc ccaggagccc     2580

ggcucccaga ccccccucaa guccaugcuc gucaucuccg gcggcgaggg cuacaucgac     2640

uuccgcaugg gcgacgaggg cggcgagucc gagcuccucg gcgaggaccu cccccucgag     2700

cccuccauca ccaaggccga gcgcucccac cucaucgucu ggcaggucau guacggcaac     2760

gaguga                                                                2766


<210>  7916
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAG61498

<400>  7916
auggugauga gauggggcga gaggaacgac gucaucgccu gggaacugcu ccaggauggg       60

guugagacca agaaugcucu uaacauugug aaaaaugacc ugauagcaaa gguagaugaa      120

uugacaugcg agaaagacgu guuacaagga gaacuggagg ccgucaagca ggcgaaacua      180

aagcucgagg aaaagaaccg ggagcuggaa gaggagcuuc gcaaagcucg agccgaaacu      240

gaggaugcac gucagaaggc caaagacgau gacgauagcg acauccccac ggcucagaga      300

aagagguuca cccgggugga aauggcacgc guucugaugg agagaaauca auacaaagaa      360

agguugaugg agcuccagga ggccgugcgg uggacagaaa ugauucgcgc uucccgagag      420

aacccugcca ugcaggaaaa gaagagaucu ucaaucuggc aguuuuucag uaggcuguuu      480

agcuccucuu cgaauacuac caaaaagcca gagccgcccg ucaaccugaa auauaaugcg      540

ccuacaucac acgugacccc aagcguaaag aaacggaguu ccacucucuc ucaauuaccc      600

ggugauaaga gcaaagcauu cgacuuucug uccgaagaga cagaggccuc acuugcuagu      660

cgucgcgaac agaagagaga gcaguacagg cagguuaagg cccaugugca aaaagaagau      720

ggccgggucc aggcauucgg guggagcuug ccucagaagu auaaacaagu gaccaacgga      780

cagggcgaga auaagaugaa aaaccugcca gugcccgucu accuacgacc ucucgacgaa      840

aaggacacgu cuaugaagcu guggugugcu guugguguga aucuuuccgg gggaaaaacu      900

cgcgauggcg gcucaguagu gggggccagc gucuuuuaua aggacguggc gggacuggau      960

accgagggua guaaacagag aucugccucc cagagcucgu uggacaagcu cgaucaagag     1020

cugaaagaac agcagaagga guuaaagaac caggaggaac ugucuucccu cguuuggauu     1080

ugcacaucaa cucacagugc aaccaaagug cuuaucauag acgcugucca accaggcaau     1140

auccuggaua gcuucacagu guguaacucc cauguauugu gcauugccuc uguuccgggg     1200

gcuagggaga ccgacuaccc cgccggagaa gaucuaagcg agucaggcca gguggacaag     1260

gcaagucugu gugguuccau gacgagcaac ucuucagccg aaacugauag ucuccuuggg     1320

ggaaucacag ucgugggcug cagcgcugag ggcgucaccg gggcggcaac uuccccuucu     1380

acaaauggag ccucgccagu gauggacaaa cccccugaaa uggaggcuga gaacagcgaa     1440

guugacgaga augugccaac cgccgaagag gcaacggaag ccaccgaggg uaacgcuggc     1500

uccgccgagg auacaguaga cauuucacag acuggggucu auaccgaaca cguguuuaca     1560

gauccccugg gaguucagau cccggaggac cugaguccug uguaccaauc uagcaaugau     1620

uccgacgcau acaaggauca gauaucaguc uugcccaacg aacaggaccu cgugcgggag     1680

gaagcgcaga aaaugagcuc ucuguuacca acuauguggc ugggcgcuca aaaugguugu     1740

cuauauguac auuccagugu ggcccagugg cgcaagugcc uccacagcau uaagcugaaa     1800

gauucuaucc uuuccauugu ucacgucaag gggaucgugu ugguggcacu ggccgacggc     1860

acccucgcua ucuuccauag aggagucgau ggccaguggg accugucaaa cuaccaccuu     1920

cuggauuugg ggaggccuca ucacaguauu cguuguauga caguugugca cgacaaagug     1980

uggugcggau aucggaauaa gauauacgua guccaaccca aagccaugaa gaucgagaaa     2040

ucguuugacg cacauccacg aaaggagagc caggugagac agcucgcuug gguuggugau     2100

ggcguguggg ucuccauuag gcuggacucu accuuacgcc uguaucacgc ccauacuuac     2160

cagcaccuac aagaugugga caucgaaccc uauguuagca agaugcucgg gacgggaaaa     2220

cugggcuucu cauuugugcg gauaacagcg cuuaugguaa guuguaacag auuguggguc     2280

gguaccggga auggcgugau uaucuccauc ccucugacug agaccaacaa gacaucugga     2340

gugccaggca auaggccggg gagcgucauu cgcguuuacg gagaugaaaa cuccgacaaa     2400

gugacccccg guacuuucau cccuuacugc ucaauggccc augcucagcu cugcuuccac     2460

ggccaccgag augcaguaaa guuuuucgug gccgucccag gacaggugau uagcccccag     2520

aguucuucca gcgggacaga ccugacgggc gauaaagcug guccuucggc ccaagagcca     2580

gggucacaga cccccuuaaa gucuaugcug guuauaagug gcggagaggg cuauaucgac     2640

uuucggaugg gggaugaagg aggcgagucc gaacuuuugg gugaggaccu cccgcuggaa     2700

ccuagcauua cuaaggcaga gcguucucau cuaaucgugu ggcaggucau guacgggaau     2760

gaguga                                                                2766


<210>  7917
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAG61498

<400>  7917
auggugauga gauggggcga gagaaacgac gugaucgccu gggagcugcu gcaggacggc       60

guggagacca agaacgcccu gaacaucgug aagaacgacc ugaucgccaa gguggacgag      120

cugaccugcg agaaggacgu gcugcagggc gagcuggagg ccgugaagca ggccaagcug      180

aagcuggagg agaagaacag agagcuggag gaggagcuga gaaaggccag agccgagacc      240

gaggacgcca gacagaaggc caaggacgac gacgacagcg acauccccac cgcccagaga      300

aagagauuca ccagagugga gauggccaga gugcugaugg agagaaacca guacaaggag      360

agacugaugg agcugcagga ggccgugaga uggaccgaga ugaucagagc cagcagagag      420

aaccccgcca ugcaggagaa gaagagaagc agcaucuggc aguucuucag cagacuguuc      480

agcagcagca gcaacaccac caagaagccc gagccccccg ugaaccugaa guacaacgcc      540

cccaccagcc acgugacccc cagcgugaag aagagaagca gcacccugag ccagcugccc      600

ggcgacaaga gcaaggccuu cgacuuccug agcgaggaga ccgaggccag ccuggccagc      660

agaagagagc agaagagaga gcaguacaga caggugaagg cccacgugca gaaggaggac      720

ggcagagugc aggccuucgg cuggagccug ccccagaagu acaagcaggu gaccaacggc      780

cagggcgaga acaagaugaa gaaccugccc gugcccgugu accugagacc ccuggacgag      840

aaggacacca gcaugaagcu guggugcgcc gugggcguga accugagcgg cggcaagacc      900

agagacggcg gcagcguggu gggcgccagc guguucuaca aggacguggc cggccuggac      960

accgagggca gcaagcagag aagcgccagc cagagcagcc uggacaagcu ggaccaggag     1020

cugaaggagc agcagaagga gcugaagaac caggaggagc ugagcagccu gguguggauc     1080

ugcaccagca cccacagcgc caccaaggug cugaucaucg acgccgugca gcccggcaac     1140

auccuggaca gcuucaccgu gugcaacagc cacgugcugu gcaucgccag cgugcccggc     1200

gccagagaga ccgacuaccc cgccggcgag gaccugagcg agagcggcca gguggacaag     1260

gccagccugu gcggcagcau gaccagcaac agcagcgccg agaccgacag ccugcugggc     1320

ggcaucaccg uggugggcug cagcgccgag ggcgugaccg gcgccgccac cagccccagc     1380

accaacggcg ccagccccgu gauggacaag ccccccgaga uggaggccga gaacagcgag     1440

guggacgaga acgugcccac cgccgaggag gccaccgagg ccaccgaggg caacgccggc     1500

agcgccgagg acaccgugga caucagccag accggcgugu acaccgagca cguguucacc     1560

gacccccugg gcgugcagau ccccgaggac cugagccccg uguaccagag cagcaacgac     1620

agcgacgccu acaaggacca gaucagcgug cugcccaacg agcaggaccu ggugagagag     1680

gaggcccaga agaugagcag ccugcugccc accauguggc ugggcgccca gaacggcugc     1740

cuguacgugc acagcagcgu ggcccagugg agaaagugcc ugcacagcau caagcugaag     1800

gacagcaucc ugagcaucgu gcacgugaag ggcaucgugc ugguggcccu ggccgacggc     1860

acccuggcca ucuuccacag aggcguggac ggccaguggg accugagcaa cuaccaccug     1920

cuggaccugg gcagacccca ccacagcauc agaugcauga ccguggugca cgacaaggug     1980

uggugcggcu acagaaacaa gaucuacgug gugcagccca aggccaugaa gaucgagaag     2040

agcuucgacg cccaccccag aaaggagagc caggugagac agcuggccug ggugggcgac     2100

ggcguguggg ugagcaucag acuggacagc acccugagac uguaccacgc ccacaccuac     2160

cagcaccugc aggacgugga caucgagccc uacgugagca agaugcuggg caccggcaag     2220

cugggcuuca gcuucgugag aaucaccgcc cugaugguga gcugcaacag acugugggug     2280

ggcaccggca acggcgugau caucagcauc ccccugaccg agaccaacaa gaccagcggc     2340

gugcccggca acagacccgg cagcgugauc agaguguacg gcgacgagaa cagcgacaag     2400

gugacccccg gcaccuucau ccccuacugc agcauggccc acgcccagcu gugcuuccac     2460

ggccacagag acgccgugaa guucuucgug gccgugcccg gccaggugau cagcccccag     2520

agcagcagca gcggcaccga ccugaccggc gacaaggccg gccccagcgc ccaggagccc     2580

ggcagccaga ccccccugaa gagcaugcug gugaucagcg gcggcgaggg cuacaucgac     2640

uucagaaugg gcgacgaggg cggcgagagc gagcugcugg gcgaggaccu gccccuggag     2700

cccagcauca ccaaggccga gagaagccac cugaucgugu ggcaggugau guacggcaac     2760

gaguga                                                                2766


<210>  7918
<211>  2766
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAG61498

<400>  7918
auggugauga gauggggcga gcggaacgac gucaucgccu gggaacugcu ccaggauggg       60

guugagacca agaaugcucu gaacauugug aaaaaugacc uuaucgccaa gguggaugaa      120

cugacaugcg agaaagacgu ccuccaggga gaacuggagg cggugaagca ggcuaaacuu      180

aagcuggagg aaaagaaccg cgagcucgaa gaggagcuga gaaaagcccg ggccgaaacg      240

gaggaugcuc gccagaaggc caaagacgau gacgauagcg acauucccac cgcucagaga      300

aagcgguuca cacgcguuga aauggccaga gugcugaugg agcggaauca auacaaagaa      360

cgccucaugg agcugcagga ggcggucaga uggaccgaaa ugauccgggc cucccgcgag      420

aacccugcua ugcaggaaaa gaagagaucu agcauuuggc aguuuuucuc ccggcuguuu      480

ucuagcuccu cuaauacaac caaaaagccg gagcccccug ugaaccugaa auauaaugcc      540

cccacaagcc acguuacccc uuccgugaag aaacgcagcu cuacgcucuc ccaacugccc      600

ggcgauaaga gcaaggcuuu cgacuuucuu ucugaagaga ccgaggccuc ccuggcgagc      660

agacgggaac agaaaagaga gcaguaccgc caggucaagg cccaugugca aaaagaagau      720

gggcgggugc aggcuuucgg auggucucuc ccucagaagu auaaacaagu cacaaacggc      780

cagggggaga auaagaugaa aaaccugccg guucccgugu accugagacc ucucgacgaa      840

aaggacaccu ccaugaagcu guggugugcc gugggaguca aucuuagcgg cggcaaaaca      900

cgcgaugggg gauccguggu uggcgcuucu guguuuuaua aggacgucgc cgggcuggau      960

accgagggaa gcaaacagcg guccgccagc cagucuuccc ucgacaagcu ggaucaagag     1020

cuuaaagaac agcagaagga gcugaagaac caggaggaac ucagcucucu gguguggauc     1080

ugcacgagca cacacuccgc uaccaaaguu cugaucauug acgcggugca acccggcaau     1140

auccucgauu cuuucacagu cuguaacagc caugugcugu gcauugccuc cgucccuggg     1200

gcuagagaga ccgacuaccc cgccggagaa gaucuuagcg agucuggcca gguggacaag     1260

gccucccugu guggcagcau gaccucuaac uccagcgcug aaacagauuc ccuccuuggg     1320

ggaaucacgg uugugggcug cucugccgag ggggucaccg gagcggcuac aagcccgucc     1380

accaauggcg ccucuccugu gauggacaaa cccccugaaa uggaggccga gaacagcgaa     1440

guugacgaga augugcccac agcugaagag gccaccgaag cuacggaggg gaacgccgga     1500

uccgcggagg auacagucga cauuagccag accggcgugu auaccgaaca cguguuuaca     1560

gauccccuug gcguucagau cccugaggac cugucuccgg ucuaccaauc cagcaaugau     1620

ucugacgccu acaaggauca gauuuccgug cuccccaacg aacaggaccu ggugcgcgag     1680

gaagcucaga aaaugagcuc ucugcucccu accauguggc ugggggccca aaauggaugu     1740

cuuuaugucc auagcuccgu ggcucagugg cggaagugcc ugcacagcau caagcucaaa     1800

gauucuaucc uguccauugu ucacgugaag ggcaucgucc ugguggcccu ugcggacggg     1860

acacucgcca uuuuccauag aggaguugau ggccaguggg accugagcaa cuaccaucug     1920

cucgaucugg ggcgccccca ccacuccauc cgguguauga cgguggucca cgacaaagug     1980

uggugcggcu auagaaauaa gauuuacguu gugcaaccua aagcuaugaa gaucgagaaa     2040

ucuuuugacg cccauccccg caaggagagc cagguccggc agcuugcuug ggugggagau     2100

ggcguguggg ucuccaucag acuggacucu acccuccggc uguaucacgc ccauacauac     2160

cagcaucugc aagauguuga cauugaaccg uaugugagca agaugcuugg gaccggaaaa     2220

cucggcuucu ccuuugugcg caucacagcc cugauggucu cuuguaacag acugugggug     2280

gggaccggaa auggcguuau uaucagcauu ccucucacgg agaccaacaa gacauccggg     2340

gugcccggca aucggccugg aagcgucauc agaguguacg gcgaugaaaa cucugacaaa     2400

guuacccccg ggacauucau cccuuacugc uccauggcuc acgcgcagcu gugcuuccac     2460

ggacaccgcg augccgugaa guuuuucguc gcugugcccg gccagguuau uagcccgcag     2520

ucuuccagcu cugggaccga ccuuacggga gauaaagccg gcccuuccgc ccaagagccc     2580

gggagccaga caccccugaa guccaugcuc gugaucagcg gcggagaggg cuauauugac     2640

uuucggaugg gggaugaagg aggcgagucu gaacugcugg gggaggaccu uccucucgaa     2700

ccgagcauca ccaaggcuga gagaucccau cugauugucu ggcaagugau guacggaaau     2760

gaguga                                                                2766


<210>  7919
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__B7Z1L7

<400>  7919

Met Gln Leu Val Leu Lys Met Asp Ser Ser Pro Asp Asn Asp Ser Trp 
1               5                   10                  15      


Leu Glu Asp Gln Trp Glu Arg Trp Leu Thr His Asp Ile Ser Leu Glu 
            20                  25                  30          


Glu Phe Glu Asp Glu Asp Leu Ser Glu Ile Thr Asp Glu Cys Gly Ile 
        35                  40                  45              


Ser Leu Gln Cys Lys Asp Thr Leu Ser Leu Arg Pro Pro Arg Ala Gly 
    50                  55                  60                  


Leu Leu Ser Ala Gly Gly Gly Gly Ala Gly Ser Arg Leu Gln Ala Glu 
65                  70                  75                  80  


Met Leu Gln Met Asp Leu Ile Asp Ala Thr Glu Asp Ser Thr Pro Asp 
                85                  90                  95      


Glu Pro Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe Met Ser 
            100                 105                 110         


Gly Arg Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe Ser Cys 
        115                 120                 125             


Ile Ile Asn Gly Glu Glu Gln Glu Gln Thr His Arg Ala Ile Phe Arg 
    130                 135                 140                 


Phe Val Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp Asp Pro 
145                 150                 155                 160 


Leu Leu Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Thr Tyr Asn 
                165                 170                 175     


Met Arg Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala Ile Glu 
            180                 185                 190         


Val Thr Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn Ser Asp 
        195                 200                 205             


Trp Val Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln Val Pro 
    210                 215                 220                 


Tyr His Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys Ile Ala 
225                 230                 235                 240 


Thr Thr Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser Cys Val 
                245                 250                 255     


Leu Glu Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys Ala Asp Asp 
            260                 265                 270         


Ser Gln Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln Leu Lys 
        275                 280                 285             


Asn Ile Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr Phe Gly 
    290                 295                 300                 


Phe Ile Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His Ala Phe 
305                 310                 315                 320 


Val Ser Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly Arg Ala 
                325                 330                 335     


Phe Gln Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro Thr Glu 
            340                 345                 350         


Asp Ile Tyr Leu Glu 
        355         


<210>  7920
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAH11553

<400>  7920
augcagcugg ugcugaagau ggauucgagc ccagacaaug acagcugguu ggaggaucaa       60

ugggagcgcu ggcucaccca ugacaucagc cuggaggagu uugaggauga agaccucucg      120

gagaucacug augagugugg caucagcuua cagugcaaag acacccuguc cuuacggccc      180

ccgcgcgccg ggcugcucuc ugcgggcggc ggcggcgcgg ggagccgguu gcaggccgag      240

augcugcaga uggaccugau cgacgcgacg gaggacucca cgccugauga acccgacguc      300

cauuucucca agaaauuccu gaacgucuuc augaguggcc gcucccgcuc cuccagugcu      360

gaguccuucg ggcuguucuc cugcaucauc aacggggagg agcaggagca gacccaccgg      420

gccauauuca gguuugugcc ucgacacgaa gacgaacuug agcuggaagu ggaugacccu      480

cugcuagugg agcuccaggc ugaagacuac ugguacgaga ccuacaacau gcgcacuggu      540

gcccggggug ucuuuccugc cuauuacgcc aucgagguca ccaaggagcc cgagcacaug      600

gcagcccugg ccaaaaacag ugacugggug gaccaguucc gggugaaguu ccugggcuca      660

guccagguuc ccuaucacaa gggcaaugac guccucugug cugcuaugca aaagauugcc      720

accacccgcc ggcucaccgu gcacuuuaac ccgcccucca gcuguguccu ggagaucagc      780

gugcggggug ugaagauagg cgucaaggcc gaugacuccc aggaggccaa ggggaauaaa      840

uguagccacu uuuuccaguu aaaaaacauc ucuuucugcg gauaucaucc aaagaacaac      900

aaguacuuug gguucaucac caagcacccc gccgaccacc gguuugccug ccacgccuuu      960

gugucugaag acuccaccaa agcccuggca gaguccgugg ggagagcauu ccagcaguuc     1020

uacaagcagu uuguggagua caccugcccc acagaagaua ucuaccugga guag           1074


<210>  7921
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAH11553

<400>  7921
augcagcugg ugcucaagau ggacagcucc cccgacaacg acagcuggcu ggaggaccag       60

ugggagcgcu ggcugaccca cgacaucucc cucgaggagu ucgaggacga ggaccugagc      120

gagaucaccg acgagugcgg caucucccug cagugcaagg acacgcucag ccugcggccg      180

ccccgcgccg ggcugcucuc cgccggcggg ggcggggcgg gcagccggcu gcaggccgag      240

augcugcaga uggaccucau cgacgccacc gaggacucca cccccgacga gcccgacguc      300

cacuucagca agaaguuccu gaacguguuc auguccggcc gcagccgguc cagcuccgcc      360

gagagcuucg ggcuguucuc cugcaucauc aacggcgagg agcaggagca gacccaccgc      420

gccaucuucc gguucgugcc gcgccacgag gacgagcucg agcuggaggu cgacgacccc      480

cugcucgugg agcugcaggc ggaggacuac ugguacgaga cguacaacau gcggaccggg      540

gcccgcggcg uguuccccgc cuacuacgcc aucgagguca ccaaggagcc cgagcacaug      600

gcggcccugg ccaagaacag cgacugggug gaccaguucc gggugaaguu ccucgggucc      660

guccaggugc cguaccacaa gggcaacgac gugcugugcg ccgccaugca gaagaucgcg      720

accacgcgcc ggcugaccgu ccacuucaac ccgcccagca gcugcgugcu cgagaucucc      780

gugcgcggcg ucaagaucgg ggugaaggcc gacgacagcc aggaggccaa gggcaacaag      840

ugcucccacu ucuuccagcu gaagaacauc agcuucugcg gguaccaccc caagaacaac      900

aaguacuucg gcuucaucac caagcacccc gccgaccacc gguucgccug ccacgcguuc      960

guguccgagg acagcaccaa ggcccuggcc gaguccgucg gccgcgccuu ccagcaguuc     1020

uacaagcagu ucguggagua cacgugcccc accgaggaca ucuaccucga guga           1074


<210>  7922
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAH11553

<400>  7922
augcagcucg uccucaagau ggacuccucc cccgacaacg acuccuggcu cgaggaccag       60

ugggagcgcu ggcucaccca cgacaucucc cucgaggagu ucgaggacga ggaccucucc      120

gagaucaccg acgagugcgg caucucccuc cagugcaagg acacccucuc ccuccgcccc      180

ccccgcgccg gccuccucuc cgccggcggc ggcggcgccg gcucccgccu ccaggccgag      240

augcuccaga uggaccucau cgacgccacc gaggacucca cccccgacga gcccgacguc      300

cacuucucca agaaguuccu caacgucuuc auguccggcc gcucccgcuc cuccuccgcc      360

gaguccuucg gccucuucuc cugcaucauc aacggcgagg agcaggagca gacccaccgc      420

gccaucuucc gcuucguccc ccgccacgag gacgagcucg agcucgaggu cgacgacccc      480

cuccucgucg agcuccaggc cgaggacuac ugguacgaga ccuacaacau gcgcaccggc      540

gcccgcggcg ucuuccccgc cuacuacgcc aucgagguca ccaaggagcc cgagcacaug      600

gccgcccucg ccaagaacuc cgacuggguc gaccaguucc gcgucaaguu ccucggcucc      660

guccaggucc ccuaccacaa gggcaacgac guccucugcg ccgccaugca gaagaucgcc      720

accacccgcc gccucaccgu ccacuucaac ccccccuccu ccugcguccu cgagaucucc      780

guccgcggcg ucaagaucgg cgucaaggcc gacgacuccc aggaggccaa gggcaacaag      840

ugcucccacu ucuuccagcu caagaacauc uccuucugcg gcuaccaccc caagaacaac      900

aaguacuucg gcuucaucac caagcacccc gccgaccacc gcuucgccug ccacgccuuc      960

gucuccgagg acuccaccaa ggcccucgcc gaguccgucg gccgcgccuu ccagcaguuc     1020

uacaagcagu ucgucgagua caccugcccc accgaggaca ucuaccucga guga           1074


<210>  7923
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAH11553

<400>  7923
augcagcugg ugcucaagau ggacagcucc cccgauaacg acucuuggcu ugaggaucaa       60

ugggaaagau ggcugaccca cgacaucuca uuggaggagu ucgaagauga agacuuaagu      120

gagauuacag augagugcgg cauaagccug caguguaaag acacucuauc ccucaggccu      180

ccacgggccg ggcugcuuuc ugcuggaggu ggcggggcag gaucgcgccu gcaggccgaa      240

auguugcaga uggaucucau cgacgcgacg gaggauucaa ccccggacga acccgauguc      300

cauuuuagca agaaauuccu gaauguuuuu augaguggcc gaucccguuc uagcuccgcu      360

gagucauucg gucuguuuag uugcauuauc aacggggagg aacaagagca gacacacaga      420

gccauuuuca gguuugugcc ucggcaugaa gacgagcucg aauuagaggu agacgaucca      480

cugcuugugg aguugcaggc agaagacuac ugguaugaga cuuacaauau gcgcaccgga      540

gccagaggcg ucuuccccgc uuauuacgca aucgaaguga caaaggagcc ugaacacaug      600

gccgcucugg ccaaaaacag cgauuggguu gaccaguuua gggugaaguu ccuaggcucu      660

guccaagugc cauaucauaa ggggaaugau guacucugug cggcaaugca gaaaauagcc      720

accacucggc gccugacagu ucacuuuaau cccccuuccu caugcgugcu ugagaucagc      780

guccgaggag ugaagauugg ugugaaagcu gacgauaguc aggaggccaa gggcaacaaa      840

uguucucacu ucuuucagcu gaagaacauc uccuucugcg gguaccaucc aaagaauaac      900

aaauauuucg gauuuauuac caagcacccg gcagaccaua gauucgcuug ucacgccuuu      960

gucagcgaag auucgacgaa agcguuggcc gagucuguug gcagggcauu ccaacaguuu     1020

uacaagcagu ucguggaaua cacuugcccc accgaggaca ucuaucucga auga           1074


<210>  7924
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAH11553

<400>  7924
augcagcugg ugcugaagau ggacagcagc cccgacaacg acagcuggcu ggaggaccag       60

ugggagagau ggcugaccca cgacaucagc cuggaggagu ucgaggacga ggaccugagc      120

gagaucaccg acgagugcgg caucagccug cagugcaagg acacccugag ccugagaccc      180

cccagagccg gccugcugag cgccggcggc ggcggcgccg gcagcagacu gcaggccgag      240

augcugcaga uggaccugau cgacgccacc gaggacagca cccccgacga gcccgacgug      300

cacuucagca agaaguuccu gaacguguuc augagcggca gaagcagaag cagcagcgcc      360

gagagcuucg gccuguucag cugcaucauc aacggcgagg agcaggagca gacccacaga      420

gccaucuuca gauucgugcc cagacacgag gacgagcugg agcuggaggu ggacgacccc      480

cugcuggugg agcugcaggc cgaggacuac ugguacgaga ccuacaacau gagaaccggc      540

gccagaggcg uguuccccgc cuacuacgcc aucgagguga ccaaggagcc cgagcacaug      600

gccgcccugg ccaagaacag cgacugggug gaccaguuca gagugaaguu ccugggcagc      660

gugcaggugc ccuaccacaa gggcaacgac gugcugugcg ccgccaugca gaagaucgcc      720

accaccagaa gacugaccgu gcacuucaac ccccccagca gcugcgugcu ggagaucagc      780

gugagaggcg ugaagaucgg cgugaaggcc gacgacagcc aggaggccaa gggcaacaag      840

ugcagccacu ucuuccagcu gaagaacauc agcuucugcg gcuaccaccc caagaacaac      900

aaguacuucg gcuucaucac caagcacccc gccgaccaca gauucgccug ccacgccuuc      960

gugagcgagg acagcaccaa ggcccuggcc gagagcgugg gcagagccuu ccagcaguuc     1020

uacaagcagu ucguggagua caccugcccc accgaggaca ucuaccugga guga           1074


<210>  7925
<211>  1074
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAH11553

<400>  7925
augcagcugg ugcucaagau ggacagcucc cccgauaacg acucuuggcu ggaggaucaa       60

ugggaaagau ggcuuaccca cgacaucagc cuggaggagu ucgaagauga agaccucucc      120

gagauuacag augagugcgg caucucucug caguguaaag acacgcuuag ccugcggccu      180

ccgcgcgccg ggcuccuguc cgcuggaggc gggggagccg gcucuagacu gcaggcggaa      240

augcuccaga uggaucugau ugacgcuacc gaggauagca cacccgacga accugauguc      300

cauuuuucca agaaauuccu uaauguuuuu augagcgggc ggucucgcuc cagcucugcc      360

gaguccuucg gacuguuuag cugcaucauu aacggcgagg aacaagagca gacccacaga      420

gccaucuucc gguuugugcc ccgccaugaa gacgagcucg aacuggaggu ggacgauccu      480

cuucuggucg agcuccaggc ugaagacuac ugguaugaga cauacaauau gagaaccggc      540

gcccgcgggg uguuccccgc uuauuacgcc aucgaaguua caaaggagcc ugaacacaug      600

gcggcccugg cuaaaaacuc ugauugggug gaccaguuuc gggucaaguu ccugggaucc      660

gugcaaguuc cguaucauaa gggcaaugau gugcucugug ccgcuaugca gaaaauugcc      720

accacgagac ggcugaccgu ccacuuuaau cccccuagcu ccugcgugcu ugagaucucu      780

gugcgcgggg ucaagauugg aguuaaagcg gacgauagcc aggaggccaa gggcaacaaa      840

uguucccacu ucuuucagcu gaagaacauc agcuucugcg gguaccaucc caagaauaac      900

aaauauuucg gauuuauuac aaagcacccu gcugaccaua gauucgccug ucacgcuuuu      960

gugucugaag auuccaccaa agcccucgcc gagagcgugg gccgggcuuu ccaacaguuu     1020

uacaagcagu ucgucgaaua cacaugcccc accgaggaca ucuaucugga auga           1074


<210>  7926
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__G1UI24

<400>  7926

Met Met Glu Ile Gln Met Asp Glu Gly Gly Gly Val Val Val Tyr Gln 
1               5                   10                  15      


Asp Asp Tyr Cys Ser Gly Ser Val Met Ser Glu Arg Val Ser Gly Leu 
            20                  25                  30          


Ala Gly Ser Ile Tyr Arg Glu Phe Glu Arg Leu Ile His Cys Tyr Asp 
        35                  40                  45              


Glu Glu Val Val Lys Glu Leu Met Pro Leu Val Val Asn Val Leu Glu 
    50                  55                  60                  


Asn Leu Asp Ser Val Leu Ser Glu Asn Gln Glu His Glu Val Glu Leu 
65                  70                  75                  80  


Glu Leu Leu Arg Glu Asp Asn Glu Gln Leu Leu Thr Gln Tyr Glu Arg 
                85                  90                  95      


Glu Lys Ala Leu Arg Arg Gln Ala Glu Glu Lys Phe Ile Glu Phe Glu 
            100                 105                 110         


Asp Ala Leu Glu Gln Glu Lys Lys Glu Leu Gln Ile Gln Val Glu His 
        115                 120                 125             


Tyr Glu Phe Gln Thr Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala 
    130                 135                 140                 


Asp Gln Ile Ser Arg Leu Glu Glu Arg Glu Ser Glu Met Lys Lys Glu 
145                 150                 155                 160 


Tyr Asn Ala Leu His Gln Arg His Thr Glu Met Ile Gln Thr Tyr Val 
                165                 170                 175     


Glu His Ile Glu Arg Ser Lys Met Gln Gln Val Gly Gly Asn Ser Gln 
            180                 185                 190         


Thr Glu Ser Ser Leu Pro Gly Arg Ser Arg Lys Glu Arg Pro Thr Ser 
        195                 200                 205             


Leu Asn Val Phe Pro Leu Ala Asp Gly Thr Val Arg Ala Gln Ile Gly 
    210                 215                 220                 


Gly Lys Leu Val Pro Ala Gly Asp His Trp His Leu Ser Asp Leu Gly 
225                 230                 235                 240 


Gln Leu Gln Ser Ser Ser Ser Tyr Gln Val Leu 
                245                 250     


<210>  7927
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAK64147

<400>  7927
augauggaga uccagaugga cgagggcggc ggcguggugg uguaccagga cgacuacugc       60

uccggcucgg ugaugucgga gcgggugucg ggccuggcgg gcuccaucua ccgcgaguuc      120

gagcgccuca uccacugcua cgacgaggag guggucaagg agcucaugcc gcugguggug      180

aacgugcugg agaaccuaga cucggugcuc agcgagaacc aggagcacga gguggagcug      240

gagcugcugc gcgaggacaa cgagcagcug cucacccagu acgagcguga gaaggcgcug      300

cgcaggcagg cggaggagaa auucauugag uuugaagaug cucuggaaca agagaagaaa      360

gagcugcaaa uccaggugga gcacuacgag uuccagacgc gccagcugga gcugaaggcc      420

aagaacuaug ccgaucagau uucccgguug gaggagcggg agucggagau gaagaaggag      480

uacaaugccc ugcaccagcg gcacacagag augauacaga ccuacgugga gcacauugag      540

agguccaaga ugcagcaggu cggaggaaac agccagaccg agagcagccu gccggggcgg      600

agcaggaagg agcgccccac cucccugaac guguuccccc uggcugacgg cacgguacgu      660

gcacagaucg ggggcaagcu cgugccugcg ggggaccacu ggcaccugag ugaccucggc      720

cagcugcagu ccagcuccag cuaccagguu uuguag                                756


<210>  7928
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAK64147

<400>  7928
augauggaga uccagaugga cgagggcggg ggcguggucg uguaccagga cgacuacugc       60

agcggguccg ugaugagcga gcgcgucucc ggccuggccg ggagcaucua ccgggaguuc      120

gagcgccuca uccacugcua cgacgaggag guggugaagg agcugaugcc ccuggucgug      180

aacgugcucg agaaccugga cuccguccug agcgagaacc aggagcacga gguggagcuc      240

gagcugcugc gggaggacaa cgagcagcuc cugacccagu acgagcgcga gaaggcccug      300

cggcgccagg cggaggagaa guucaucgag uucgaggacg cccucgagca ggagaagaag      360

gagcugcaga uccaggugga gcacuacgag uuccagaccc ggcagcugga gcucaaggcc      420

aagaacuacg ccgaccagau cucccgccug gaggagcggg agagcgagau gaagaaggag      480

uacaacgccc ugcaccagcg ccacacggag augauccaga ccuacgucga gcacaucgag      540

cgguccaaga ugcagcaggu cggcggcaac agccagaccg aguccagccu cccggggcgc      600

ucccggaagg agcgccccac cagccugaac guguuccccc uggcggacgg cacggugcgg      660

gcccagaucg ggggcaagcu cgugcccgcc ggggaccacu ggcaccuguc cgaccugggc      720

cagcuccaga gcuccagcuc cuaccaggug cuguga                                756


<210>  7929
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAK64147

<400>  7929
augauggaga uccagaugga cgagggcggc ggcgucgucg ucuaccagga cgacuacugc       60

uccggcuccg ucauguccga gcgcgucucc ggccucgccg gcuccaucua ccgcgaguuc      120

gagcgccuca uccacugcua cgacgaggag gucgucaagg agcucaugcc ccucgucguc      180

aacguccucg agaaccucga cuccguccuc uccgagaacc aggagcacga ggucgagcuc      240

gagcuccucc gcgaggacaa cgagcagcuc cucacccagu acgagcgcga gaaggcccuc      300

cgccgccagg ccgaggagaa guucaucgag uucgaggacg cccucgagca ggagaagaag      360

gagcuccaga uccaggucga gcacuacgag uuccagaccc gccagcucga gcucaaggcc      420

aagaacuacg ccgaccagau cucccgccuc gaggagcgcg aguccgagau gaagaaggag      480

uacaacgccc uccaccagcg ccacaccgag augauccaga ccuacgucga gcacaucgag      540

cgcuccaaga ugcagcaggu cggcggcaac ucccagaccg aguccucccu ccccggccgc      600

ucccgcaagg agcgccccac cucccucaac gucuuccccc ucgccgacgg caccguccgc      660

gcccagaucg gcggcaagcu cguccccgcc ggcgaccacu ggcaccucuc cgaccucggc      720

cagcuccagu ccuccuccuc cuaccagguc cucuga                                756


<210>  7930
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAK64147

<400>  7930
augauggaga uccagaugga cgaaggcggg ggaguggucg uuuaccaaga ugacuauugc       60

agcgguuccg ugaugucuga gagaguauca ggccuggccg ggaguauuua cagggaguuc      120

gaacggcuca uacacuguua ugaugaagag guggucaagg agcuuaugcc ccuggugguu      180

aacguguugg aaaauuuaga cagcguccug uccgagaacc aggaacauga gguggagcua      240

gaacuccugc gcgaggauaa ugaacagcuu cugacccagu acgagcgaga aaaggcuuug      300

cguagacaag cagaggagaa auuuaucgag uucgaagacg cccucgaaca ggagaaaaag      360

gaacugcaga uucagguaga gcacuaugag uuucaaacaa ggcagcugga acucaaagcg      420

aagaacuacg cugaucagau cucucgguua gaggaacgcg agucggaaau gaagaaagag      480

uauaaugccc ugcaucagag acacacugag augauucaaa cguacguuga acauaucgag      540

aggucaaaga ugcaacaggu gggaggcaac agccagaccg aaaguucccu uccuggucgg      600

ucucgcaaag agcgaccaac uagcuugaau gucuucccgc uggcagacgg gacagugaga      660

gcccagauag gaggcaagcu agugcccgcu ggcgaucacu ggcaccucuc cgaccugggg      720

cagcuucagu caaguagcuc uuaccaaguc cuguga                                756


<210>  7931
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAK64147

<400>  7931
augauggaga uccagaugga cgagggcggc ggcguggugg uguaccagga cgacuacugc       60

agcggcagcg ugaugagcga gagagugagc ggccuggccg gcagcaucua cagagaguuc      120

gagagacuga uccacugcua cgacgaggag guggugaagg agcugaugcc ccugguggug      180

aacgugcugg agaaccugga cagcgugcug agcgagaacc aggagcacga gguggagcug      240

gagcugcuga gagaggacaa cgagcagcug cugacccagu acgagagaga gaaggcccug      300

agaagacagg ccgaggagaa guucaucgag uucgaggacg cccuggagca ggagaagaag      360

gagcugcaga uccaggugga gcacuacgag uuccagacca gacagcugga gcugaaggcc      420

aagaacuacg ccgaccagau cagcagacug gaggagagag agagcgagau gaagaaggag      480

uacaacgccc ugcaccagag acacaccgag augauccaga ccuacgugga gcacaucgag      540

agaagcaaga ugcagcaggu gggcggcaac agccagaccg agagcagccu gcccggcaga      600

agcagaaagg agagacccac cagccugaac guguuccccc uggccgacgg caccgugaga      660

gcccagaucg gcggcaagcu ggugcccgcc ggcgaccacu ggcaccugag cgaccugggc      720

cagcugcaga gcagcagcag cuaccaggug cuguga                                756


<210>  7932
<211>  756
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAK64147

<400>  7932
augauggaga uccagaugga cgaaggcggg ggaguggucg uuuaccaaga ugacuauugc       60

agcggcuccg ugaugucuga gagagugagc gggcuggccg gauccauuua ccgggaguuc      120

gaacgccuca uccacuguua ugaugaagag gucgugaagg agcugaugcc ccuuguugug      180

aacguccugg aaaaucucga cucugugcug agcgagaacc aggaacauga gguugagcuu      240

gaacugcuca gagaggauaa ugaacagcug cugacccagu acgagcggga aaaagcucuc      300

cgcagacaag ccgaggagaa guuuauugag uucgaagacg cgcuggaaca ggagaaaaag      360

gaacuucaga uccaggugga gcacuaugag uuucaaacac ggcagcugga acucaaagcu      420

aagaacuacg ccgaucagau uucccgccug gaggaaagag agucugaaau gaagaaagag      480

uauaaugccc uucaucagcg gcacacggag augauccaaa ccuacgucga acauaucgag      540

cgcagcaaga ugcaacaggu gggcgggaac ucccagacag aaagcucucu gccuggaaga      600

ucccggaaag agcgcccgac cagccucaau guguuccccc uggcugacgg cacagucaga      660

gcccagauug gcgggaagcu gguuccugcu ggagaucacu ggcaccucuc ugaccugggc      720

cagcuucagu ccucuagcuc cuaccaagug cuguga                                756


<210>  7933
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__G5E966

<400>  7933

Met Ile His Phe Ile Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu 
1               5                   10                  15      


Gln Lys Trp Tyr Ile Thr Leu Pro Asp Lys Glu Arg Lys Lys Ile Thr 
            20                  25                  30          


Arg Glu Ile Val Gln Ile Ile Leu Ser Arg Gly His Arg Thr Ser Ser 
        35                  40                  45              


Phe Val Asp Trp Lys Glu Leu Lys Leu Val Tyr Lys Arg Ser Val Ser 
    50                  55                  60                  


Trp Ile Leu Ser Leu Ile Leu Lys Arg Leu Ile Ser Ser Trp Thr Ser 
65                  70                  75                  80  


Leu 
    


<210>  7934
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__EAW70814

<400>  7934
augauacauu ucauauugcu cuucagucga caagggaaau uacggcuaca gaaaugguac       60

aucacucucc cugauaaaga gaggaagaag aucacccggg aaauuguuca gauuauucuc      120

ucccgugguc acaggacaag caguuuuguu gacuggaagg agcuaaaacu uguuuauaaa      180

aggucuguga gcuggauauu aucuuuaauu uugaaaaggc uuauuucauc cuggacgagu      240

uuauaa                                                                 246


<210>  7935
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__EAW70814

<400>  7935
augauccacu ucauccuccu guucagccgc cagggcaagc ugcggcugca gaagugguac       60

aucacccucc ccgacaagga gcgcaagaag aucacccggg agaucgugca gaucauccug      120

ucccgcgggc accggacgag cuccuucguc gacuggaagg agcugaagcu cguguacaag      180

cgcagcgugu ccuggauccu gagccugauc cucaagcggc ugaucuccag cuggaccucc      240

cuguga                                                                 246


<210>  7936
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__EAW70814

<400>  7936
augauccacu ucauccuccu cuucucccgc cagggcaagc uccgccucca gaagugguac       60

aucacccucc ccgacaagga gcgcaagaag aucacccgcg agaucgucca gaucauccuc      120

ucccgcggcc accgcaccuc cuccuucguc gacuggaagg agcucaagcu cgucuacaag      180

cgcuccgucu ccuggauccu cucccucauc cucaagcgcc ucaucuccuc cuggaccucc      240

cucuga                                                                 246


<210>  7937
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__EAW70814

<400>  7937
augauccacu ucauucugcu cuuuagcaga cagggcaaac uuaggcugca aaagugguac       60

auaaccuugc ccgacaagga gcggaaaaag aucacacgcg aaauugugca gaucauuuua      120

ucccgagggc aucguacuuc uucauucguc gauuggaaag agcugaagcu aguuuauaag      180

agaaguguga gcuggauccu cucccugaua cuuaaaaggc ugaucucuuc guggacguca      240

uuguga                                                                 246


<210>  7938
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__EAW70814

<400>  7938
augauccacu ucauccugcu guucagcaga cagggcaagc ugagacugca gaagugguac       60

aucacccugc ccgacaagga gagaaagaag aucaccagag agaucgugca gaucauccug      120

agcagaggcc acagaaccag cagcuucgug gacuggaagg agcugaagcu gguguacaag      180

agaagcguga gcuggauccu gagccugauc cugaagagac ugaucagcag cuggaccagc      240

cuguga                                                                 246


<210>  7939
<211>  246
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__EAW70814

<400>  7939
augauccacu ucauucugcu cuuuagcaga cagggcaagc ugcggcuuca aaaaugguac       60

aucacccugc ccgacaagga gcgcaaaaag auuacaagag aaaucgugca gauuauccuc      120

ucccgggggc aucgcacguc uagcuucguc gauuggaaag agcugaaacu uguuuauaag      180

agauccgugu cuuggauccu gagccucauu cugaagcggc ugaucuccuc uuggaccagc      240

cucuga                                                                 246


<210>  7940
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__O75843

<400>  7940

Met Val Val Pro Ser Leu Lys Leu Gln Asp Leu Ile Glu Glu Ile Arg 
1               5                   10                  15      


Gly Ala Lys Thr Gln Ala Gln Glu Arg Glu Val Ile Gln Lys Glu Cys 
            20                  25                  30          


Ala His Ile Arg Ala Ser Phe Arg Asp Gly Asp Pro Val His Arg His 
        35                  40                  45              


Arg Gln Leu Ala Lys Leu Leu Tyr Val His Met Leu Gly Tyr Pro Ala 
    50                  55                  60                  


His Phe Gly Gln Met Glu Cys Leu Lys Leu Ile Ala Ser Ser Arg Phe 
65                  70                  75                  80  


Thr Asp Lys Arg Val Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu 
                85                  90                  95      


Arg His Asp Ala His Leu Leu Ile Thr Asn Ser Ile Lys Asn Asp Leu 
            100                 105                 110         


Ser Gln Gly Ile Gln Pro Val Gln Gly Leu Ala Leu Cys Thr Leu Ser 
        115                 120                 125             


Thr Met Gly Ser Ala Glu Met Cys Arg Asp Leu Ala Pro Glu Val Glu 
    130                 135                 140                 


Lys Leu Leu Leu Gln Pro Ser Pro Tyr Val Arg Lys Lys Ala Ile Leu 
145                 150                 155                 160 


Thr Ala Val His Met Ile Arg Lys Val Pro Glu Leu Ser Ser Val Phe 
                165                 170                 175     


Leu Pro Pro Cys Ala Gln Leu Leu His Glu Arg His His Gly Ile Leu 
            180                 185                 190         


Leu Gly Thr Ile Thr Leu Ile Thr Glu Leu Cys Glu Arg Ser Pro Ala 
        195                 200                 205             


Ala Leu Arg His Phe Arg Lys Val Val Pro Gln Leu Val His Ile Leu 
    210                 215                 220                 


Arg Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser Ile Ser Gly 
225                 230                 235                 240 


Val Ser Asp Pro Phe Leu Gln Val Gln Ile Leu Arg Leu Leu Arg Ile 
                245                 250                 255     


Leu Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu 
            260                 265                 270         


Ala Gln Val Ala Thr Asn Thr Asp Thr Ser Arg Asn Ala Gly Asn Ala 
        275                 280                 285             


Val Leu Phe Glu Thr Val Leu Thr Ile Met Asp Ile Arg Ser Ala Ala 
    290                 295                 300                 


Gly Leu Arg Val Leu Ala Val Asn Ile Leu Gly Arg Phe Leu Leu Asn 
305                 310                 315                 320 


Ser Asp Arg Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu 
                325                 330                 335     


Val Gln Ser Asp His Ser Ala Val Gln Arg His Arg Pro Thr Val Val 
            340                 345                 350         


Glu Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg Arg Ala Leu Glu 
        355                 360                 365             


Leu Ser Leu Ala Leu Val Asn Ser Ser Asn Val Arg Ala Met Met Gln 
    370                 375                 380                 


Glu Leu Gln Ala Phe Leu Glu Ser Cys Pro Pro Asp Leu Arg Ala Asp 
385                 390                 395                 400 


Cys Ala Ser Gly Ile Leu Leu Ala Ala Glu Arg Phe Ala Pro Thr Lys 
                405                 410                 415     


Arg Trp His Ile Asp Thr Ile Leu His Val Leu Thr Thr Ala Gly Thr 
            420                 425                 430         


His Val Arg Asp Asp Ala Val Ala Asn Leu Thr Gln Leu Ile Gly Gly 
        435                 440                 445             


Ala Gln Glu Leu His Ala Tyr Ser Val Arg Arg Leu Tyr Asn Ala Leu 
    450                 455                 460                 


Ala Glu Asp Ile Ser Gln Gln Pro Leu Val Gln Val Ala Ala Trp Cys 
465                 470                 475                 480 


Ile Gly Glu Tyr Gly Asp Leu Leu Leu Ala Gly Asn Cys Glu Glu Ile 
                485                 490                 495     


Glu Pro Leu Gln Val Asp Glu Glu Glu Val Leu Ala Leu Leu Glu Lys 
            500                 505                 510         


Val Leu Gln Ser His Met Ser Leu Pro Ala Thr Arg Gly Tyr Ala Leu 
        515                 520                 525             


Thr Ala Leu Met Lys Leu Ser Thr Arg Leu Cys Gly Asp Asn Asn Arg 
    530                 535                 540                 


Ile Arg Gln Val Val Ser Ile Tyr Gly Ser Cys Leu Asp Val Glu Leu 
545                 550                 555                 560 


Gln Gln Arg Ala Val Glu Tyr Asp Thr Leu Phe Arg Lys Tyr Asp His 
                565                 570                 575     


Met Arg Ala Ala Ile Leu Glu Lys Met Pro Leu Val Glu Arg Asp Gly 
            580                 585                 590         


Pro Gln Ala Asp Glu Glu Ala Lys Glu Ser Lys Glu Ala Ala Gln Leu 
        595                 600                 605             


Ser Glu Ala Ala Pro Val Pro Thr Glu Pro Gln Ala Ser Gln Leu Leu 
    610                 615                 620                 


Asp Leu Leu Asp Leu Leu Asp Gly Ala Ser Gly Asp Val Gln His Pro 
625                 630                 635                 640 


Pro His Leu Asp Pro Ser Pro Gly Gly Ala Leu Val His Leu Leu Asp 
                645                 650                 655     


Leu Pro Cys Val Pro Pro Pro Pro Ala Pro Ile Pro Asp Leu Lys Val 
            660                 665                 670         


Phe Glu Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro Pro 
        675                 680                 685             


Glu Asn Pro Ala Leu Leu Leu Ile Thr Ile Thr Ala Thr Asn Phe Ser 
    690                 695                 700                 


Glu Gly Asp Val Thr His Phe Ile Cys Gln Ala Ala Val Pro Lys Ser 
705                 710                 715                 720 


Leu Gln Leu Gln Leu Gln Ala Pro Ser Gly Asn Thr Val Pro Ala Arg 
                725                 730                 735     


Gly Gly Leu Pro Ile Thr Gln Leu Phe Arg Ile Leu Asn Pro Asn Lys 
            740                 745                 750         


Ala Pro Leu Arg Leu Lys Leu Arg Leu Thr Tyr Asp His Phe His Gln 
        755                 760                 765             


Ser Val Gln Glu Ile Phe Glu Val Asn Asn Leu Pro Val Glu Ser Trp 
    770                 775                 780                 


Gln 
785 


<210>  7941
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAA33390

<400>  7941
augguggugc cuucgcugaa gcuucaggac cucaucgaag agauucgcgg ggccaagacu       60

caggcccagg agcgggaggu gauccaaaag gagugugccc acauccgggc cuccuuccgc      120

gacggggacc cagugcacag gcaccggcag cuggccaaac ugcucuacgu ccacauguug      180

ggcuaccccg cccacuuugg acagauggag ugccugaaac ugaucgccuc cuccagauuc      240

acagacaaga gggugggcua ccugggggcc augcuucuau uggaugagag gcacgaugcc      300

caccugcuca uuaccaacag caucaagaau gaccugagcc aggggauuca gccaguacaa      360

ggccuggccu ugugcacuuu gagcaccaug ggcucugcug agaugugccg agaccuggcc      420

ccagaggugg agaaacugcu ccugcagccc agucccuacg ugcgcaagaa ggcuauucug      480

acugcagugc acaugauccg gaaggucccu gaacucucca gugucuuccu cccacccugu      540

gcccaacugc uucaugagcg ucaccauggc auccugcugg gcaccaucac gcugaucacg      600

gagcucugcg aacgaagccc ugcagcccuc aggcacuucc gaaagguggu accccagcug      660

guacacaucc uccggacucu ggugacaaug ggauacucca cagaacacag cauaucugga      720

gucagcgacc ccuuccugca gguccagaua cuucgucugc uucggauccu gggccggaac      780

cacgaggaga gcagugagac caugaaugac uugcuggccc agguggccac uaacacggac      840

accagccgaa augccggaaa ugcgguccug uuugagacag uacucaccau cauggauauc      900

cgcucugcag cuggccuacg gguucuagcu gucaacauuc uuggucgcuu ccuacucaac      960

agugacagga acauuaggua uguagcccug acaucacugc uucgacuggu gcagucugau     1020

cacagugcug ugcagcggca ucggcccacu gugguggaau gucuacggga aacugaugcc     1080

ucccucagcc ggagagcccu ggaacuaagc cuggcucugg uaaauagcuc caaugugcga     1140

gccaugaugc aagagcugca ggccuuucug gaguccugcc cuccugaccu acgggcugac     1200

ugugccucag gcauccugcu ggcugcagag agguuugcuc caaccaaacg cuggcacaua     1260

gacaccaucc ugcaugugcu gacaacggcg ggcacccaug ugcgggauga ugcaguggcc     1320

aaccugaccc agcugauugg gggggcccag gagcuacaug ccuacucugu gcgccgccuc     1380

uacaaugccc uggcagaaga cauuucccag caaccacugg ugcagguggc agccuggugc     1440

auuggggagu auggggaccu ccugcuggca gggaacugcg aggagauuga gccccuucag     1500

guggacgaag aggaagugcu ggcauugcug gaaaaggugc ugcaguccca caugucccug     1560

ccagccacuc gaggauaugc ccucacagcc cucaugaagc ucagcacucg ccucuguggg     1620

gacaacaacc gcauccgcca gguggugucc aucuacggga gcugcuugga cguggagcug     1680

cagcagcggg cuguggagua ugacacacuc uuccggaaau acgaccacau gagggcugcc     1740

auccuggaaa aaaugccucu uguggagcga gauggcccuc aggcugauga ggaagcaaag     1800

gaaagcaaag aagcagccca gcuuucagaa gcagccccag ugcccacaga gccccaggcc     1860

ucacagcucc uggaucugcu agaucuccug gauggggcuu cuggggaugu ccagcauccu     1920

ccccaucugg accccucccc aggaggugcc cugguacacc ugcuugaccu ucccugugua     1980

ccuccacccc cagcucccau cccagaucuc aaaguguuug agcgugaggg aguacagcug     2040

aaucugucuu ucauucgacc cccugaaaac ccugcuuugc uguuaaucac caucacugcc     2100

accaacuucu cagaggguga ugucacccau uucaucugcc aggcugcugu gcccaagagu     2160

cuccagcugc agcugcaggc ccccaguggg aacacaguuc cagcucgggg uggccuuccu     2220

aucacccagc ucuucagaau ccucaauccu aacaaggccc cccugcggcu aaagcugcgc     2280

cucaccuacg accacuuuca ccagucggug caggagaucu uugaggugaa caacuugccu     2340

guggaaucgu ggcaguaa                                                   2358


<210>  7942
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAA33390

<400>  7942
augguggucc ccagccugaa gcuccaggac cugaucgagg agauccgcgg cgccaagacc       60

caggcccagg agcgggaggu gauccagaag gagugcgcgc acauccgcgc cuccuuccgg      120

gacggggacc cggugcaccg ccaccggcag cuggccaagc uccuguacgu ccacaugcug      180

ggcuaccccg cccacuucgg gcagauggag ugccucaagc ugaucgccag cucccgcuuc      240

accgacaagc gggugggcua ccugggggcg augcuccugc uggacgagcg ccacgacgcc      300

caccuccuga ucacgaacag caucaagaac gaccuguccc agggcaucca gcccgugcag      360

ggccucgccc ugugcacccu gagcaccaug ggguccgccg agaugugccg ggaccucgcg      420

cccgaggucg agaagcugcu gcuccagccg agccccuacg ugcgcaagaa ggccauccug      480

accgccgugc acaugauccg gaaggucccc gagcugucca gcguguuccu gcccccgugc      540

gcccagcugc ugcacgagcg ccaccacggc auccuccugg ggacgaucac ccugaucacc      600

gagcucugcg agcggucccc cgccgcgcug cgccacuucc ggaagguggu cccccagcug      660

gugcacaucc uccgcacccu ggugacgaug ggcuacagca ccgagcacuc caucagcggg      720

gucuccgacc ccuuccucca ggugcagauc cuccggcugc ugcgcauccu cggccggaac      780

cacgaggaga gcuccgagac caugaacgac cugcuggccc agguggccac caacacggac      840

accagccgca acgccggcaa cgccguccuc uucgagaccg ugcugaccau cauggacauc      900

cgguccgcgg ccgggcugcg cgugcucgcc gucaacaucc ugggccgcuu ccugcucaac      960

agcgaccgga acauccgcua cguggcccug acgagccugc ugcggcucgu gcaguccgac     1020

cacagcgccg uccagcgcca ccggccgacc guggucgagu gccugcgcga gaccgacgcg     1080

ucccugagcc ggcgcgcccu cgagcugucc cuggcccucg ugaacagcuc caacgugcgg     1140

gccaugaugc aggagcugca ggccuuccug gagagcugcc cgcccgaccu ccgcgcggac     1200

ugcgccuccg ggauccugcu ggccgccgag cgguucgcgc ccaccaagcg cuggcacauc     1260

gacacgaucc uccacguccu gaccaccgcc ggcacccacg ugcgggacga cgccguggcc     1320

aaccugacgc agcucaucgg cggggcccag gagcugcacg cguacagcgu ccgccggcug     1380

uacaacgccc ucgccgagga caucucccag cagccccugg uccagguggc cgccuggugc     1440

aucggcgagu acggggaccu gcuccuggcg ggcaacugcg aggagaucga gccccuccag     1500

guggacgagg aggaggugcu ggcccugcug gagaaggugc uccagagcca caugucccug     1560

cccgccaccc gcggguacgc ccugaccgcc cucaugaagc ugagcacccg gcugugcggc     1620

gacaacaacc gcauccggca ggucgugucc aucuacggca gcugccucga cguggagcug     1680

cagcagcgcg cggucgagua cgacacgcug uuccgcaagu acgaccacau gcgggccgcc     1740

auccucgaga agaugccccu gguggagcgc gacgggccgc aggccgacga ggaggcgaag     1800

gaguccaagg aggccgccca gcugagcgag gccgcccccg ugcccaccga gccccaggcg     1860

ucccagcucc uggaccugcu cgaccugcug gacggcgcca gcggggacgu ccagcacccg     1920

ccccaccucg accccagccc cggcggggcc cuggugcacc uccucgaccu gccgugcgug     1980

cccccgccgc ccgcccccau ccccgaccug aaggucuucg agcgggaggg cgugcagcuc     2040

aaccuguccu ucauccgccc gcccgagaac cccgcccugc uccugaucac caucaccgcg     2100

acgaacuuca gcgagggcga cgugacccac uucaucugcc aggccgccgu ccccaagucc     2160

cugcagcucc agcugcaggc ccccagcggg aacaccgugc ccgcccgggg cgggcugccc     2220

aucacccagc uguuccgcau ccugaacccc aacaaggcgc cgcugcggcu caagcugcgc     2280

cugacguacg accacuucca ccaguccgug caggagaucu ucgaggucaa caaccucccc     2340

guggagagcu ggcaguga                                                   2358


<210>  7943
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAA33390

<400>  7943
auggucgucc ccucccucaa gcuccaggac cucaucgagg agauccgcgg cgccaagacc       60

caggcccagg agcgcgaggu cauccagaag gagugcgccc acauccgcgc cuccuuccgc      120

gacggcgacc ccguccaccg ccaccgccag cucgccaagc uccucuacgu ccacaugcuc      180

ggcuaccccg cccacuucgg ccagauggag ugccucaagc ucaucgccuc cucccgcuuc      240

accgacaagc gcgucggcua ccucggcgcc augcuccucc ucgacgagcg ccacgacgcc      300

caccuccuca ucaccaacuc caucaagaac gaccucuccc agggcaucca gcccguccag      360

ggccucgccc ucugcacccu cuccaccaug ggcuccgccg agaugugccg cgaccucgcc      420

cccgaggucg agaagcuccu ccuccagccc ucccccuacg uccgcaagaa ggccauccuc      480

accgccgucc acaugauccg caaggucccc gagcucuccu ccgucuuccu cccccccugc      540

gcccagcucc uccacgagcg ccaccacggc auccuccucg gcaccaucac ccucaucacc      600

gagcucugcg agcgcucccc cgccgcccuc cgccacuucc gcaaggucgu cccccagcuc      660

guccacaucc uccgcacccu cgucaccaug ggcuacucca ccgagcacuc caucuccggc      720

gucuccgacc ccuuccucca gguccagauc cuccgccucc uccgcauccu cggccgcaac      780

cacgaggagu ccuccgagac caugaacgac cuccucgccc aggucgccac caacaccgac      840

accucccgca acgccggcaa cgccguccuc uucgagaccg uccucaccau cauggacauc      900

cgcuccgccg ccggccuccg cguccucgcc gucaacaucc ucggccgcuu ccuccucaac      960

uccgaccgca acauccgcua cgucgcccuc accucccucc uccgccucgu ccaguccgac     1020

cacuccgccg uccagcgcca ccgccccacc gucgucgagu gccuccgcga gaccgacgcc     1080

ucccucuccc gccgcgcccu cgagcucucc cucgcccucg ucaacuccuc caacguccgc     1140

gccaugaugc aggagcucca ggccuuccuc gaguccugcc cccccgaccu ccgcgccgac     1200

ugcgccuccg gcauccuccu cgccgccgag cgcuucgccc ccaccaagcg cuggcacauc     1260

gacaccaucc uccacguccu caccaccgcc ggcacccacg uccgcgacga cgccgucgcc     1320

aaccucaccc agcucaucgg cggcgcccag gagcuccacg ccuacuccgu ccgccgccuc     1380

uacaacgccc ucgccgagga caucucccag cagccccucg uccaggucgc cgccuggugc     1440

aucggcgagu acggcgaccu ccuccucgcc ggcaacugcg aggagaucga gccccuccag     1500

gucgacgagg aggagguccu cgcccuccuc gagaaggucc uccaguccca caugucccuc     1560

cccgccaccc gcggcuacgc ccucaccgcc cucaugaagc ucuccacccg ccucugcggc     1620

gacaacaacc gcauccgcca ggucgucucc aucuacggcu ccugccucga cgucgagcuc     1680

cagcagcgcg ccgucgagua cgacacccuc uuccgcaagu acgaccacau gcgcgccgcc     1740

auccucgaga agaugccccu cgucgagcgc gacggccccc aggccgacga ggaggccaag     1800

gaguccaagg aggccgccca gcucuccgag gccgcccccg uccccaccga gccccaggcc     1860

ucccagcucc ucgaccuccu cgaccuccuc gacggcgccu ccggcgacgu ccagcacccc     1920

ccccaccucg accccucccc cggcggcgcc cucguccacc uccucgaccu ccccugcguc     1980

cccccccccc ccgcccccau ccccgaccuc aaggucuucg agcgcgaggg cguccagcuc     2040

aaccucuccu ucauccgccc ccccgagaac cccgcccucc uccucaucac caucaccgcc     2100

accaacuucu ccgagggcga cgucacccac uucaucugcc aggccgccgu ccccaagucc     2160

cuccagcucc agcuccaggc ccccuccggc aacaccgucc ccgcccgcgg cggccucccc     2220

aucacccagc ucuuccgcau ccucaacccc aacaaggccc cccuccgccu caagcuccgc     2280

cucaccuacg accacuucca ccaguccguc caggagaucu ucgaggucaa caaccucccc     2340

gucgaguccu ggcaguga                                                   2358


<210>  7944
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAA33390

<400>  7944
augguggucc ccagccugaa gcuccaggac cuuaucgagg aaauuagagg cgccaaaacc       60

caagcucagg agagggaagu uauacagaag gagugcgcac acauccgggc cuccuuccgc      120

gauggggacc cugugcaucg acaccgucag cuggcgaaau uguuauacgu acauaugcug      180

ggauauccag cucacuuugg ucaaauggaa ugucuaaagc ucauugccuc uucaagauuc      240

acagauaaaa gggugggcua ccugggggca augcuucugu uggacgagcg gcaugaugcc      300

caccuccuga ucacuaacag uauuaagaau gaccugagcc agggaaucca gccgguccag      360

ggccucgcuu uaugcacgcu guccaccaug gguucugcag agaugugucg cgaucuugcc      420

cccgaagugg agaaguugcu gcuacaaccu ucgccauaug uuagaaagaa agcuauacuc      480

acagccgugc acaugaucag gaaagucccc gaacugucaa gcguguuucu uccuccaugc      540

gcgcagcugu ugcaugagcg gcaccauggg auucuccugg gaacuaucac cuuaauuaca      600

gagcugugug aacgcagucc cgcagcccuc cgacacuuca gaaagguagu uccucagcuu      660

gugcacaucc ugaggaccuu ggucacuaug ggcuacucca cagagcauuc uauaagcggc      720

guguccgacc cauuucuaca ggugcaaauu cugcggcucc ugcguauccu ugggcgcaac      780

cacgaagagu caagugaaac caugaaugau cuguuggcuc aggucgccac gaacacugac      840

accagcagaa augcaggaaa cgcuguucuc uucgagacag ugcugacuau uauggauauc      900

aggucugccg cggguuuacg gguacuggcc gugaauaucc uaggccgauu ucuccugaac      960

uccgaccgca auauuagaua ugucgcacuu accucauugc ugaggcucgu gcagagcgau     1020

cauagugcug uucaacggca ccgcccgaca guggucgagu gccugagaga aaccgacgcc     1080

ucucuuucca ggcgugcucu ggaguugagc cucgcccugg ugaacucguc uaauguacgg     1140

gcaaugaugc aggaauuaca ggccuuccug gaguccuguc ccccugaccu acgagcugau     1200

ugcgcgucag ggauacuccu ggcagccgaa agauuugcuc caacgaaaag guggcauauc     1260

gacacuauuc uucacguuuu gacaaccgcc ggaacucacg ugcgcgauga cgcagucgcc     1320

aaccugacac agcucaucgg cggugcucaa gagcugcaug ccuacagugu gcggagauua     1380

uauaaugcac uggcggagga uauaagccag cagccccuug uccagguggc ugccuggugu     1440

auuggggaau acggagacuu gcuccuggca ggcaacugcg aggaaaucga gccucuacaa     1500

guugaugaag aggaggugcu ggcccuccug gaaaagguac uucaguccca caugucuuug     1560

ccagcuacca ggggcuacgc ccugacggca uuaaugaagc ucagcacccg ccuguguggg     1620

gacaauaacc gaauccggca ggucguguca auuuauggaa guugccuuga uguugagcug     1680

cagcaacgug cuguggaaua cgacacauug uucagaaaau augaucauau gagggccgcg     1740

auccucgaga agaugccccu ggucgagcgc gacgguccgc aggccgacga agaggcuaaa     1800

gaauccaagg aggcagccca gcuaagcgaa gcugccccug ugcccacuga gccacaggca     1860

ucucaacugc ucgaucugcu ugacuugcug gauggcgcgu caggggacgu acagcacccu     1920

ccccacuuag auccaagucc cggaggcgcc cucgugcauc ugcuugaccu gccuugcguu     1980

ccaccgcccc cugcuccaau ucccgaucua aaagucuuug agcgggaagg ugugcagcuc     2040

aaccugagcu ucauaagacc uccagagaau cccgccuugc uguuaaucac cauuacagca     2100

acuaacuuuu ccgaagggga cgugacccac uucaucuguc aagcugccgu cccgaagucu     2160

cuccagcugc agcuucaggc accuucgggc aauacaguuc cagccagggg aggccugccc     2220

aucacccaau uguuccgcau ucucaacccu aauaaagcuc cccugcgacu aaagcugcgg     2280

cuuacuuacg aucauuuuca ccagagcgug caggagauau ucgaagugaa caaucuccca     2340

guagaguccu ggcaguga                                                   2358


<210>  7945
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAA33390

<400>  7945
augguggugc ccagccugaa gcugcaggac cugaucgagg agaucagagg cgccaagacc       60

caggcccagg agagagaggu gauccagaag gagugcgccc acaucagagc cagcuucaga      120

gacggcgacc ccgugcacag acacagacag cuggccaagc ugcuguacgu gcacaugcug      180

ggcuaccccg cccacuucgg ccagauggag ugccugaagc ugaucgccag cagcagauuc      240

accgacaaga gagugggcua ccugggcgcc augcugcugc uggacgagag acacgacgcc      300

caccugcuga ucaccaacag caucaagaac gaccugagcc agggcaucca gcccgugcag      360

ggccuggccc ugugcacccu gagcaccaug ggcagcgccg agaugugcag agaccuggcc      420

cccgaggugg agaagcugcu gcugcagccc agccccuacg ugagaaagaa ggccauccug      480

accgccgugc acaugaucag aaaggugccc gagcugagca gcguguuccu gccccccugc      540

gcccagcugc ugcacgagag acaccacggc auccugcugg gcaccaucac ccugaucacc      600

gagcugugcg agagaagccc cgccgcccug agacacuuca gaaagguggu gccccagcug      660

gugcacaucc ugagaacccu ggugaccaug ggcuacagca ccgagcacag caucagcggc      720

gugagcgacc ccuuccugca ggugcagauc cugagacugc ugagaauccu gggcagaaac      780

cacgaggaga gcagcgagac caugaacgac cugcuggccc agguggccac caacaccgac      840

accagcagaa acgccggcaa cgccgugcug uucgagaccg ugcugaccau cauggacauc      900

agaagcgccg ccggccugag agugcuggcc gugaacaucc ugggcagauu ccugcugaac      960

agcgacagaa acaucagaua cguggcccug accagccugc ugagacuggu gcagagcgac     1020

cacagcgccg ugcagagaca cagacccacc gugguggagu gccugagaga gaccgacgcc     1080

agccugagca gaagagcccu ggagcugagc cuggcccugg ugaacagcag caacgugaga     1140

gccaugaugc aggagcugca ggccuuccug gagagcugcc cccccgaccu gagagccgac     1200

ugcgccagcg gcauccugcu ggccgccgag agauucgccc ccaccaagag auggcacauc     1260

gacaccaucc ugcacgugcu gaccaccgcc ggcacccacg ugagagacga cgccguggcc     1320

aaccugaccc agcugaucgg cggcgcccag gagcugcacg ccuacagcgu gagaagacug     1380

uacaacgccc uggccgagga caucagccag cagccccugg ugcagguggc cgccuggugc     1440

aucggcgagu acggcgaccu gcugcuggcc ggcaacugcg aggagaucga gccccugcag     1500

guggacgagg aggaggugcu ggcccugcug gagaaggugc ugcagagcca caugagccug     1560

cccgccacca gaggcuacgc ccugaccgcc cugaugaagc ugagcaccag acugugcggc     1620

gacaacaaca gaaucagaca gguggugagc aucuacggca gcugccugga cguggagcug     1680

cagcagagag ccguggagua cgacacccug uucagaaagu acgaccacau gagagccgcc     1740

auccuggaga agaugccccu gguggagaga gacggccccc aggccgacga ggaggccaag     1800

gagagcaagg aggccgccca gcugagcgag gccgcccccg ugcccaccga gccccaggcc     1860

agccagcugc uggaccugcu ggaccugcug gacggcgcca gcggcgacgu gcagcacccc     1920

ccccaccugg accccagccc cggcggcgcc cuggugcacc ugcuggaccu gcccugcgug     1980

cccccccccc ccgcccccau ccccgaccug aagguguucg agagagaggg cgugcagcug     2040

aaccugagcu ucaucagacc ccccgagaac cccgcccugc ugcugaucac caucaccgcc     2100

accaacuuca gcgagggcga cgugacccac uucaucugcc aggccgccgu gcccaagagc     2160

cugcagcugc agcugcaggc ccccagcggc aacaccgugc ccgccagagg cggccugccc     2220

aucacccagc uguucagaau ccugaacccc aacaaggccc cccugagacu gaagcugaga     2280

cugaccuacg accacuucca ccagagcgug caggagaucu ucgaggugaa caaccugccc     2340

guggagagcu ggcaguga                                                   2358


<210>  7946
<211>  2358
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAA33390

<400>  7946
augguggucc ccagccugaa gcuccaggac cugaucgagg aaauuagagg cgccaaaacc       60

caagcucagg agcgggaagu uauccagaag gagugcgccc acauucgcgc guccuucaga      120

gauggggacc cugugcaucg gcaccgccag cuugcuaaac ugcucuacgu gcauaugcug      180

ggauauccgg cccacuuugg ccaaauggaa ugucuuaagc ugaucgccuc uagcagauuc      240

acagauaaac gggucgggua ccucggagcu augcugcugc ucgacgagcg ccaugaugcc      300

caucugcuua uuacgaacuc caucaagaau gaccugucuc agggcaucca gcccgugcag      360

gggcucgcuc ugugcacccu uagcacaaug ggauccgccg agauguguag agaucuggcg      420

ccugaaguug agaagcuccu gcugcaaccc ucuccuuaug ugcggaaaaa ggccauucuc      480

accgcugucc acaugauccg caaagugccc gaacugagcu ccguuuuucu uccuccgugc      540

gcccagcugc uccacgagag acaccauggc auucugcuug gcacaaucac ccugauuaca      600

gagcucugug aacggagccc cgcugcccug cgccacuuca gaaagguggu cccucagcug      660

gugcacaucc uccggacccu ggugacgaug ggguacucua ccgagcauuc cauuagcgga      720

gucucugacc ccuuucuuca gguucaaauc cugcgccucc ugagaauccu uggccggaac      780

cacgaagagu ccagcgaaac aaugaaugau cugcucgccc agguggcgac caacacagac      840

accucuagaa augcugggaa cgccgugcug uucgagacgg uccugacaau uauggauauc      900

cgcuccgcug ccggacuccg ggugcuggcc guuaauauuc uuggcagauu ucugcucaac      960

agcgaccgca auauccggua uguggcucug accucccugc uuagacucgu ccagucugau     1020

cauagcgcgg ugcaacgcca ccggccuaca guuguggagu gccugagaga aaccgacgcc     1080

ucccugagcc gccgggcucu cgagcugucu cuugcccugg ucaacuccag caaugugaga     1140

gccaugaugc aggaacucca ggcuuuccug gagucuuguc ccccggaccu gcgcgccgau     1200

ugcgcgagcg ggauucuucu cgcugccgaa cgguuugccc cuaccaaaag auggcauauc     1260

gacacaaucc ugcacguccu gacgaccgcu ggaacacacg ugcgggauga cgccguugcu     1320

aaccucaccc agcugauugg cggcgcccaa gagcuucaug cguacuccgu gcgcagacug     1380

uauaaugccc ucgcugagga uaucucucag cagccccugg uccagguggc cgcuuggugu     1440

auuggggaau acggagaccu gcuucucgcc ggcaacugcg aggaaaucga gccucugcaa     1500

guugaugaag aggaggugcu ggcgcuccug gaaaaggucc uucagagcca caugucccug     1560

cccgccacac ggggguacgc ucucaccgcc cugaugaagc ugagcacgag acuuugugga     1620

gacaauaacc gcauuagaca gguggugucu aucuauggcu ccugccucga uguugagcug     1680

cagcaacggg cugucgaaua cgacacacug uuccgcaaau augaucauau gagagccgcc     1740

auccucgaga agaugccccu gguggagcgg gacgggccuc aggcugacga agaggcgaaa     1800

gaaagcaagg aggccgcuca gcuuucugaa gccgccccgg ugcccaccga gccucaggcu     1860

ucccaacugc ucgaucugcu ggaccuucug gauggagcca gcggcgacgu ccagcauccc     1920

ccucaccucg aucccucccc gggcggggcg cuggugcacc uccuggaccu uccuugcguu     1980

cccccucccc cugcucccau uccggaucug aaaguguuug agcgcgaagg aguccagcuc     2040

aaccugucuu ucaucagacc ucccgagaau cccgcccugc uucugauuac caucacagcc     2100

accaacuuua gcgaaggcga cgugacacac uucauuuguc aagcugccgu uccuaagucc     2160

cuccagcugc agcuccaggc gccgucuggg aauacggugc ccgcucgggg aggccugccu     2220

aucacccaac uuuuccgcau ucugaacccc aauaaagccc cucucagacu gaagcugcgg     2280

cuuacauacg aucauuuuca ccagagcguc caggagaucu ucgaagugaa caaucugccc     2340

guugaguccu ggcaguga                                                   2358


<210>  7947
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__P05412

<400>  7947

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  7948
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAA59197

<400>  7948
augacugcaa agauggaaac gaccuucuau gacgaugccc ucaacgccuc guuccucccg       60

uccgagagcg gaccuuaugg cuacaguaac cccaagaucc ugaaacagag caugacccug      120

aaccuggccg acccaguggg gagccugaag ccgcaccucc gcgccaagaa cucggaccuc      180

cucaccucgc ccgacguggg gcugcucaag cuggcgucgc ccgagcugga gcgccugaua      240

auccagucca gcaacgggca caucaccacc acgccgaccc ccacccaguu ccugugcccc      300

aagaacguga cagaugagca ggagggguuc gccgagggcu ucgugcgcgc ccuggccgaa      360

cugcacagcc agaacacgcu gcccagcguc acgucggcgg cgcagccggu caacggggca      420

ggcauggugg cucccgcggu agccucggug gcagggggca gcggcagcgg cggcuucagc      480

gccagccugc acagcgagcc gccggucuac gcaaaccuca gcaacuucaa cccaggcgcg      540

cugagcagcg gcggcggggc gcccuccuac ggcgcggccg gccuggccuu ucccgcgcaa      600

ccccagcagc agcagcagcc gccgcaccac cugccccagc agaugcccgu gcagcacccg      660

cggcugcagg cccugaagga ggagccucag acagugcccg agaugcccgg cgagacaccg      720

ccccuguccc ccaucgacau ggagucccag gagcggauca aggcggagag gaagcgcaug      780

aggaaccgca ucgcugccuc caagugccga aaaaggaagc uggagagaau cgcccggcug      840

gaggaaaaag ugaaaaccuu gaaagcucag aacucggagc uggcguccac ggccaacaug      900

cucagggaac agguggcaca gcuuaaacag aaagucauga accacguuaa cagugggugc      960

caacucaugc uaacgcagca guugcaaaca uuuuga                                996


<210>  7949
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAA59197

<400>  7949
augaccgcca agauggagac cacguucuac gacgacgccc ugaacgcgag cuuccucccc       60

uccgagagcg gcccguacgg guacuccaac cccaagaucc ugaagcagag caugacccug      120

aaccucgccg accccguggg cucccugaag ccccaccucc gcgccaagaa cagcgaccug      180

cugaccuccc cggacgucgg gcugcucaag cuggccagcc ccgagcugga gcggcucauc      240

auccagucca gcaacggcca caucaccacg acccccaccc ccacccaguu ccugugcccg      300

aagaacguga cggacgagca ggagggguuc gccgagggcu ucgugcgcgc gcuggccgag      360

cuccacuccc agaacacccu gcccagcguc accuccgccg cccagcccgu gaacggcgcg      420

gggauggugg cccccgccgu cgccagcgug gccggcgggu ccggcagcgg gggcuucucc      480

gcgagccugc acuccgagcc gcccguguac gccaaccuca gcaacuucaa ccccggcgcc      540

cugagcuccg ggggcggggc ccccagcuac ggcgccgcgg gccuggccuu cccggcccag      600

ccccagcagc agcagcagcc gccccaccac cucccccagc agaugcccgu ccagcacccc      660

cggcugcagg cccugaagga ggagccccag accgugccgg agaugcccgg ggagacgccg      720

ccccucuccc ccaucgacau ggagagccag gagcgcauca aggccgagcg gaagcgcaug      780

cggaaccgca ucgcggccuc caagugccgg aagcgcaagc uggagcggau cgcccgccug      840

gaggagaagg ugaagacccu caaggcccag aacagcgagc uggccuccac cgcgaacaug      900

cugcgggagc aggucgccca gcucaagcag aaggugauga accacgugaa cagcggcugc      960

cagcugaugc ugacccagca gcuccagacg uucuga                                996


<210>  7950
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAA59197

<400>  7950
augaccgcca agauggagac caccuucuac gacgacgccc ucaacgccuc cuuccucccc       60

uccgaguccg gccccuacgg cuacuccaac cccaagaucc ucaagcaguc caugacccuc      120

aaccucgccg accccgucgg cucccucaag ccccaccucc gcgccaagaa cuccgaccuc      180

cucaccuccc ccgacgucgg ccuccucaag cucgccuccc ccgagcucga gcgccucauc      240

auccaguccu ccaacggcca caucaccacc acccccaccc ccacccaguu ccucugcccc      300

aagaacguca ccgacgagca ggagggcuuc gccgagggcu ucguccgcgc ccucgccgag      360

cuccacuccc agaacacccu ccccuccguc accuccgccg cccagcccgu caacggcgcc      420

ggcauggucg cccccgccgu cgccuccguc gccggcggcu ccggcuccgg cggcuucucc      480

gccucccucc acuccgagcc ccccgucuac gccaaccucu ccaacuucaa ccccggcgcc      540

cucuccuccg gcggcggcgc ccccuccuac ggcgccgccg gccucgccuu ccccgcccag      600

ccccagcagc agcagcagcc cccccaccac cucccccagc agaugcccgu ccagcacccc      660

cgccuccagg cccucaagga ggagccccag accguccccg agaugcccgg cgagaccccc      720

ccccucuccc ccaucgacau ggagucccag gagcgcauca aggccgagcg caagcgcaug      780

cgcaaccgca ucgccgccuc caagugccgc aagcgcaagc ucgagcgcau cgcccgccuc      840

gaggagaagg ucaagacccu caaggcccag aacuccgagc ucgccuccac cgccaacaug      900

cuccgcgagc aggucgccca gcucaagcag aaggucauga accacgucaa cuccggcugc      960

cagcucaugc ucacccagca gcuccagacc uucuga                                996


<210>  7951
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAA59197

<400>  7951
augaccgcca agauggagac aacuuucuac gacgaugcuc ugaacgcauc cuuucucccc       60

uccgaaucug gcccuuaugg guacucaaau ccaaaaaucc uuaagcagag uaugacgcug      120

aacuuggccg acccgguggg uagcuuaaaa ccccaccuga gagcgaagaa uagcgaucua      180

cucaccucuc cugacgucgg acugcuuaaa cuggcuucgc cagaguugga aaggcucauu      240

auacaaucaa gcaacggcca uaucacaacu acccccacac cuacccaguu ccugugccca      300

aagaauguua cugaugagca ggaaggguuu gccgagggau ucgugcgggc acuggccgag      360

cuccacaguc agaacacauu acccuccgua accucugcug cacaaccugu gaauggcgcc      420

gguauggucg cuccagccgu ggcgagcguu gcagggggau ccggcucagg cggguuuagu      480

gccagccugc auucugaacc gcccguguau gcuaaccuuu ccaauuucaa cccuggagcc      540

uugucaagcg guggcggggc accaaguuac ggagcugccg gccuggcguu ucccgcccag      600

ccucagcagc aacagcagcc accccaccau cuaccgcagc aaaugccugu ccagcacccc      660

cgccuccagg cacugaagga ggaaccacaa acggugccug agaugcccgg ugagacucca      720

ccccuuucuc cuauugacau ggaaucccag gagcgaauca aagcugaacg uaagagaaug      780

aggaaucgga uugccgcuag caaaugucgc aagagaaaac uggagaggau cgcccgguug      840

gaagagaagg uaaagacccu caaagcacag aacucggagc uggccucuac agcuaauaug      900

uuacgcgaac agguugcgca acugaagcag aaagugauga accacgucaa uuccgggugc      960

cagcucaugc uuacucagca acugcagacc uucuga                                996


<210>  7952
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAA59197

<400>  7952
augaccgcca agauggagac caccuucuac gacgacgccc ugaacgccag cuuccugccc       60

agcgagagcg gccccuacgg cuacagcaac cccaagaucc ugaagcagag caugacccug      120

aaccuggccg accccguggg cagccugaag ccccaccuga gagccaagaa cagcgaccug      180

cugaccagcc ccgacguggg ccugcugaag cuggccagcc ccgagcugga gagacugauc      240

auccagagca gcaacggcca caucaccacc acccccaccc ccacccaguu ccugugcccc      300

aagaacguga ccgacgagca ggagggcuuc gccgagggcu ucgugagagc ccuggccgag      360

cugcacagcc agaacacccu gcccagcgug accagcgccg cccagcccgu gaacggcgcc      420

ggcauggugg cccccgccgu ggccagcgug gccggcggca gcggcagcgg cggcuucagc      480

gccagccugc acagcgagcc ccccguguac gccaaccuga gcaacuucaa ccccggcgcc      540

cugagcagcg gcggcggcgc ccccagcuac ggcgccgccg gccuggccuu ccccgcccag      600

ccccagcagc agcagcagcc cccccaccac cugccccagc agaugcccgu gcagcacccc      660

agacugcagg cccugaagga ggagccccag accgugcccg agaugcccgg cgagaccccc      720

ccccugagcc ccaucgacau ggagagccag gagagaauca aggccgagag aaagagaaug      780

agaaacagaa ucgccgccag caagugcaga aagagaaagc uggagagaau cgccagacug      840

gaggagaagg ugaagacccu gaaggcccag aacagcgagc uggccagcac cgccaacaug      900

cugagagagc agguggccca gcugaagcag aaggugauga accacgugaa cagcggcugc      960

cagcugaugc ugacccagca gcugcagacc uucuga                                996


<210>  7953
<211>  996
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAA59197

<400>  7953
augaccgcca agauggagac aacguucuac gacgaugcuc ugaacgccag cuuucucccc       60

uccgaaucug gcccuuaugg guacagcaau ccgaaaaucc ugaagcaguc caugacccuu      120

aaccuggcgg accccguggg aucucucaaa ccucaccuga gagcuaagaa uagcgaucuu      180

cugacauccc ccgacguggg ccuccugaaa cuggccucuc cugagcucga acggcugauu      240

auccaaagcu ccaacgggca uauuaccaca acccccacac cuacccaguu ccuuugcccg      300

aagaauguua cggaugagca ggaaggauuu gccgagggcu ucgugcgcgc ucuggccgag      360

cuccacagcc agaacacccu gcccucugug acauccgcug cccaaccugu caauggggcg      420

ggaauggugg cccccgcugu ugccagcgug gcuggcggcu cuggguccgg aggcuuuagc      480

gccucucuuc auuccgaacc ucccgucuau gcgaaccuga gcaauuucaa cccgggggcc      540

cucuccucug gaggcggggc uccuagcuac ggagccgcug gccuggccuu ucccgcccag      600

ccucagcagc aacagcagcc uccccaccau cugccccagc aaaugccggu gcagcacccc      660

agacuccagg cucugaagga ggaaccucaa accguucccg agaugccugg cgagacaccc      720

ccgcuuuccc cuaucgacau ggaaagccag gagcggauua aagcggaacg caagagaaug      780

cggaaucgca ucgccgcuuc uaaauguaga aagcggaaac uggagcgcau cgccagacuc      840

gaagagaagg ugaagacccu gaaagcccag aacuccgagc uugcuagcac ggccaauaug      900

cugcgggaac aggucgcgca acucaagcag aaagugauga accacgucaa uucugggugc      960

cagcugaugc ugacacagca acuccagacc uucuga                                996


<210>  7954
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__P53677

<400>  7954

Met Ile His Ser Leu Phe Leu Ile Asn Ser Ser Gly Asp Ile Phe Leu 
1               5                   10                  15      


Glu Lys His Trp Lys Ser Val Val Ser Arg Ser Val Cys Asp Tyr Phe 
            20                  25                  30          


Phe Glu Ala Gln Glu Arg Ala Thr Glu Ala Glu Asn Val Pro Pro Val 
        35                  40                  45              


Ile Pro Thr Pro His His Tyr Leu Leu Ser Val Tyr Arg His Lys Ile 
    50                  55                  60                  


Phe Phe Val Ala Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
65                  70                  75                  80  


Glu Phe Leu His Arg Val Val Asp Thr Phe Gln Asp Tyr Phe Gly Val 
                85                  90                  95      


Cys Ser Glu Pro Val Ile Lys Asp Asn Val Val Val Val Tyr Glu Val 
            100                 105                 110         


Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
        115                 120                 125             


Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Thr Val Val 
    130                 135                 140                 


Asn Thr Ile Thr Gly Ser Thr Asn Val Gly Asp Gln Leu Pro Thr Gly 
145                 150                 155                 160 


Gln Leu Ser Val Val Pro Trp Arg Arg Thr Gly Val Lys Tyr Thr Asn 
                165                 170                 175     


Asn Glu Ala Tyr Phe Asp Val Ile Glu Glu Ile Asp Ala Ile Ile Asp 
            180                 185                 190         


Lys Ser Gly Ser Thr Ile Thr Ala Glu Ile Gln Gly Val Ile Asp Ala 
        195                 200                 205             


Cys Val Lys Leu Thr Gly Met Pro Asp Leu Thr Leu Ser Phe Met Asn 
    210                 215                 220                 


Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Val Arg Phe Lys 
225                 230                 235                 240 


Arg Trp Glu Ser Glu Arg Ile Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                245                 250                 255     


Phe Arg Leu Leu Ser Tyr His Val Ser Ala Gln Asn Leu Val Ala Ile 
            260                 265                 270         


Pro Val Tyr Val Lys His Asn Ile Ser Phe Arg Asp Ser Ser Ser Leu 
        275                 280                 285             


Gly Arg Phe Glu Ile Thr Val Gly Pro Lys Gln Thr Met Gly Lys Thr 
    290                 295                 300                 


Ile Glu Gly Val Thr Val Thr Ser Gln Met Pro Lys Gly Val Leu Asn 
305                 310                 315                 320 


Met Ser Leu Thr Pro Ser Gln Gly Thr His Thr Phe Asp Pro Val Thr 
                325                 330                 335     


Lys Met Leu Ser Trp Asp Val Gly Lys Ile Asn Pro Gln Lys Leu Pro 
            340                 345                 350         


Ser Leu Lys Gly Thr Met Ser Leu Gln Ala Gly Ala Ser Lys Pro Asp 
        355                 360                 365             


Glu Asn Pro Thr Ile Asn Leu Gln Phe Lys Ile Gln Gln Leu Ala Ile 
    370                 375                 380                 


Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
385                 390                 395                 400 


Pro Phe Lys Gly Ile Lys Tyr Met Thr Lys Ala Gly Lys Phe Gln Val 
                405                 410                 415     


Arg Thr 
        


<210>  7955
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAH56398

<400>  7955
augauccaua gucuuuucuu gaucaacucc ucuggagaca uuuuccugga gaaacauugg       60

aaaagugugg ucagccguuc uguuugugau uacuuuuuug aggcgcaaga gagagcuacu      120

gaggcagaaa augugccucc gguuaucccu accccucacc acuaucucuu aaguguuuac      180

cgccacaaga ucuuuuuugu ggccgugauc cagacggagg uccccccucu guuugucauu      240

gaguuucuuc accgaguggu ggacacauuu caggauuauu uuggagucug uucagagcca      300

gugaucaaag acaauguagu ugugguuuau gagguauugg aagagaugcu ugacaauggu      360

uuuccauugg cuaccgaguc gaacauucuu aaagaacuca uaaagccucc uaccauccuu      420

cgaacgguug ucaacaccau cacaggaagc acgaaugugg gugaccagcu ucccacuggg      480

cagcugucag uggugccuug gcgacggacu ggggugaaau auaccaacaa ugaggccuau      540

uuugauguga uugaagagau ugaugcaauu auugauaaau caggcuccac aauuacugcu      600

gagauccagg gggugauuga ugccuguguc aagcugacug gcaugccaga ccuuacacuu      660

uccuucauga acccuagguu guuggaugau gucagcuucc auccuugugu ucguuucaaa      720

cgcugggaau cugagcgcau ccucuccuuc aucccuccug auggaaacuu ccgccugcug      780

ucuuaccaug ucagugcaca gaaucugguu gcaaucccag uguaugucaa acauaacauc      840

aguuuccggg acaguaguuc ccuuggacgc uuugaaauaa cggugggacc caagcagacg      900

auggggaaga ccauugaggg agugacuguc accagccaga ugcccaaggg gguccugaac      960

augagccuua cuccaucaca ggggacacac acauucgacc cagucacaaa gaugcugucu     1020

ugggauguag gaaaaauaaa uccacaaaag cuaccaaguu ugaaggggac caugagucuu     1080

caggcuggag cuuccaaacc agaugaaaac cccacaauua accugcaguu uaagauccag     1140

cagcuggcca uuucuggacu caaggugaau cgucuggaua uguauggaga aaaguacaaa     1200

cccuuuaagg gcauaaaaua caugaccaaa gcugggaagu uccaaguucg aaccuga        1257


<210>  7956
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAH56398

<400>  7956
augauccaca gccuguuccu caucaacucc agcggcgaca ucuuccugga gaagcacugg       60

aaguccgugg ucagccgcuc cgugugcgac uacuucuucg aggcccagga gcgggccacc      120

gaggcggaga acgugccccc ggucaucccc acgccccacc acuaccugcu cagcguguac      180

cgccacaaga ucuucuucgu ggccgucauc cagaccgagg ugcccccgcu guucgugauc      240

gaguuccugc accgggucgu ggacaccuuc caggacuacu ucggggugug cuccgagccc      300

gucaucaagg acaacguggu ggucguguac gaggugcucg aggagaugcu ggacaacggc      360

uucccccugg ccaccgagag caacauccuc aaggagcuga ucaagccccc gaccauccug      420

cgcacggucg ugaacaccau caccgggucc accaacgugg gcgaccagcu ccccacgggg      480

cagcugagcg ucgugcccug gcggcgcacc ggcgugaagu acaccaacaa cgaggccuac      540

uucgacguca ucgaggagau cgacgccauc aucgacaagu ccggcagcac caucacggcg      600

gagauccagg gggugaucga cgccugcguc aagcugaccg gcaugcccga ccucacccug      660

uccuucauga acccgcggcu gcucgacgac gugagcuucc accccugcgu gcgcuucaag      720

cggugggagu ccgagcgcau ccugagcuuc aucccgcccg acgggaacuu ccggcugcuc      780

uccuaccacg ucagcgccca gaaccuggug gccauccccg uguacgucaa gcacaacauc      840

uccuuccgcg acagcagcuc ccugggccgg uucgagauca ccguggggcc caagcagacg      900

augggcaaga ccaucgaggg cgugaccguc accagccaga ugcccaaggg ggugcucaac      960

augucccuga cgcccagcca gggcacccac accuucgacc cggugaccaa gaugcugucc     1020

ugggacgucg ggaagaucaa cccccagaag cuccccagcc ugaagggcac gaugucccug     1080

caggcgggcg ccagcaagcc cgacgagaac ccgaccauca accuccaguu caagauccag     1140

cagcuggcca ucuccgggcu gaaggugaac cgccucgaca uguacggcga gaaguacaag     1200

cccuucaagg ggaucaagua caugaccaag gccggcaagu uccaggugcg gaccuga        1257


<210>  7957
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAH56398

<400>  7957
augauccacu cccucuuccu caucaacucc uccggcgaca ucuuccucga gaagcacugg       60

aaguccgucg ucucccgcuc cgucugcgac uacuucuucg aggcccagga gcgcgccacc      120

gaggccgaga acgucccccc cgucaucccc accccccacc acuaccuccu cuccgucuac      180

cgccacaaga ucuucuucgu cgccgucauc cagaccgagg uccccccccu cuucgucauc      240

gaguuccucc accgcgucgu cgacaccuuc caggacuacu ucggcgucug cuccgagccc      300

gucaucaagg acaacgucgu cgucgucuac gagguccucg aggagaugcu cgacaacggc      360

uucccccucg ccaccgaguc caacauccuc aaggagcuca ucaagccccc caccauccuc      420

cgcaccgucg ucaacaccau caccggcucc accaacgucg gcgaccagcu ccccaccggc      480

cagcucuccg ucguccccug gcgccgcacc ggcgucaagu acaccaacaa cgaggccuac      540

uucgacguca ucgaggagau cgacgccauc aucgacaagu ccggcuccac caucaccgcc      600

gagauccagg gcgucaucga cgccugcguc aagcucaccg gcaugcccga ccucacccuc      660

uccuucauga acccccgccu ccucgacgac gucuccuucc accccugcgu ccgcuucaag      720

cgcugggagu ccgagcgcau ccucuccuuc aucccccccg acggcaacuu ccgccuccuc      780

uccuaccacg ucuccgccca gaaccucguc gccauccccg ucuacgucaa gcacaacauc      840

uccuuccgcg acuccuccuc ccucggccgc uucgagauca ccgucggccc caagcagacc      900

augggcaaga ccaucgaggg cgucaccguc accucccaga ugcccaaggg cguccucaac      960

augucccuca cccccuccca gggcacccac accuucgacc ccgucaccaa gaugcucucc     1020

ugggacgucg gcaagaucaa cccccagaag cuccccuccc ucaagggcac caugucccuc     1080

caggccggcg ccuccaagcc cgacgagaac cccaccauca accuccaguu caagauccag     1140

cagcucgcca ucuccggccu caaggucaac cgccucgaca uguacggcga gaaguacaag     1200

cccuucaagg gcaucaagua caugaccaag gccggcaagu uccagguccg caccuga        1257


<210>  7958
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAH56398

<400>  7958
augauccaca gccuguuccu cauuaacucc ucuggcgaca uauuucuuga gaagcauugg       60

aaaucagugg ucaguagaag cguuugcgau uacuucuuug aagcccagga gagggcuacc      120

gaagcagaga augugccccc uguaauccca acaccgcacc auuaucuguu guccguguac      180

cggcacaaga uuuucuuugu cgccgugauc caaacugaag uucccccuuu auucgugauu      240

gaguuucugc aucgcgucgu ggacacguuc caggauuauu uugggguaug uucugagcca      300

guuaucaaag acaacguggu cgugguguac gaaguccuag aggaaaugcu cgauaaugga      360

uucccccugg cgaccgaguc gaacauacuu aaggagcuga ucaaaccucc aacaauuuug      420

cgaacuguug ugaauaccau cacagguuca accaacguag gcgaccagcu ccccacuggg      480

cagcugagcg uggucccuug gcguagaaca ggagugaagu auaccaauaa cgaggcuuac      540

uuugauguua uugaagaaau cgacgccaua auugauaaga guggcuccac gaucacugca      600

gagauucaag gugugaucga cgccugcguc aaacugaccg ggaugccaga ucucacauua      660

ucuuucauga auccgaggcu gcuugacgau gugagcuuuc accccugugu acgguucaag      720

cgcugggaau ccgagagaau cuugucauuc auuccuccag acggaaacuu uaggcugcua      780

aguuaucacg uuagcgcuca gaaucucgug gcaauacccg ucuacgugaa acauaacauc      840

ucuuuccggg acuccucaag ccugggccgc uuugagauua cugucggccc uaagcagacc      900

auggggaaaa caaucgaagg agugaccguu acgagucaga ugccaaaggg ugugcuuaau      960

augucucuga cucccuccca aggcacacac accuucgauc cgguaacuaa gauguugagc     1020

ugggacgucg ggaaaauaaa cccucagaag cuccccucgc ugaaaggaac aaugucuuua     1080

caggccggcg cuuccaagcc agaugagaau ccuaccauua accugcaguu uaaaauccaa     1140

cagcucgcca ucucaggucu uaaggugaac cgacuggaca uguacgggga aaaauauaag     1200

cccuucaagg gaauuaaaua caugacgaag gcgggcaaau uucagguuag aaccuga        1257


<210>  7959
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAH56398

<400>  7959
augauccaca gccuguuccu gaucaacagc agcggcgaca ucuuccugga gaagcacugg       60

aagagcgugg ugagcagaag cgugugcgac uacuucuucg aggcccagga gagagccacc      120

gaggccgaga acgugccccc cgugaucccc accccccacc acuaccugcu gagcguguac      180

agacacaaga ucuucuucgu ggccgugauc cagaccgagg ugcccccccu guucgugauc      240

gaguuccugc acagaguggu ggacaccuuc caggacuacu ucggcgugug cagcgagccc      300

gugaucaagg acaacguggu ggugguguac gaggugcugg aggagaugcu ggacaacggc      360

uucccccugg ccaccgagag caacauccug aaggagcuga ucaagccccc caccauccug      420

agaaccgugg ugaacaccau caccggcagc accaacgugg gcgaccagcu gcccaccggc      480

cagcugagcg uggugcccug gagaagaacc ggcgugaagu acaccaacaa cgaggccuac      540

uucgacguga ucgaggagau cgacgccauc aucgacaaga gcggcagcac caucaccgcc      600

gagauccagg gcgugaucga cgccugcgug aagcugaccg gcaugcccga ccugacccug      660

agcuucauga accccagacu gcuggacgac gugagcuucc accccugcgu gagauucaag      720

agaugggaga gcgagagaau ccugagcuuc aucccccccg acggcaacuu cagacugcug      780

agcuaccacg ugagcgccca gaaccuggug gccauccccg uguacgugaa gcacaacauc      840

agcuucagag acagcagcag ccugggcaga uucgagauca ccgugggccc caagcagacc      900

augggcaaga ccaucgaggg cgugaccgug accagccaga ugcccaaggg cgugcugaac      960

augagccuga cccccagcca gggcacccac accuucgacc ccgugaccaa gaugcugagc     1020

ugggacgugg gcaagaucaa cccccagaag cugcccagcc ugaagggcac caugagccug     1080

caggccggcg ccagcaagcc cgacgagaac cccaccauca accugcaguu caagauccag     1140

cagcuggcca ucagcggccu gaaggugaac agacuggaca uguacggcga gaaguacaag     1200

cccuucaagg gcaucaagua caugaccaag gccggcaagu uccaggugag aaccuga        1257


<210>  7960
<211>  1257
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAH56398

<400>  7960
augauccaca gccuguuccu cauuaacucc ucuggcgaca ucuuucugga gaagcauugg       60

aaaagcgugg ucuccagauc uguuugcgau uacuucuuug aagcccagga gcgggcuacc      120

gaagccgaga augugccccc ugugauuccg acaccccacc auuaucuucu gagcgucuac      180

cgccacaaga ucuucuuugu ggcgguuauu caaacggaag ugccuccccu cuucgucauc      240

gaguuucugc auagaguggu ugacaccuuc caggauuauu uuggggugug uuccgagccu      300

gucaucaaag acaacguggu ggucguuuac gaagugcuug aggaaaugcu ggauaaugga      360

uucccccucg cuacagaguc uaacauucug aaggagcuga ucaaaccucc gaccauucuc      420

cggacagugg ucaauaccau cacaggcagc accaacgugg gggaccagcu gcccacggga      480

cagcuuuccg uugugccuug gcgcagaacc ggcgucaagu auacaaauaa cgaagccuac      540

uuugauguga uugaggaaau cgacgccauu aucgauaaga gcgggucuac caucacagcu      600

gagauucaag gaguuaucga cgccugcgug aaacugaccg gcaugcccga ucucacgcug      660

uccuucauga auccucggcu ucuggacgau gucagcuuuc accccugugu gcgcuucaag      720

agaugggaau cugagcggau ucucuccuuc aucccgccug acggcaacuu ucgccugcug      780

agcuaucacg ucucugcuca gaaucucgug gccauucccg uuuacgugaa acauaacauc      840

uccuucagag acagcuccuc ucuggggcgg uuugagauca cagucggacc uaagcagacc      900

augggcaaaa caauugaagg ggugaccguu accagccaga ugcccaaggg agugcuuaau      960

augucccuga cacccagcca aggcacgcac accuucgauc cugucacaaa gaugcucucu     1020

ugggacgugg ggaaaaucaa cccgcagaag cugcccuccc uuaaaggaac caugagccug     1080

caggcgggcg ccucuaagcc ugaugagaau cccacaauua accuccaguu uaaaauccaa     1140

cagcuggcua uuagcggccu gaaggugaac cgccucgaca uguacgggga aaaauauaag     1200

ccuuucaagg gaaucaaaua caugaccaag gccggcaaau uucagguuag aacguga        1257


<210>  7961
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__P61966

<400>  7961

Met Met Arg Phe Met Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu 
1               5                   10                  15      


Gln Lys Trp Tyr Leu Ala Thr Ser Asp Lys Glu Arg Lys Lys Met Val 
            20                  25                  30          


Arg Glu Leu Met Gln Val Val Leu Ala Arg Lys Pro Lys Met Cys Ser 
        35                  40                  45              


Phe Leu Glu Trp Arg Asp Leu Lys Val Val Tyr Lys Arg Tyr Ala Ser 
    50                  55                  60                  


Leu Tyr Phe Cys Cys Ala Ile Glu Gly Gln Asp Asn Glu Leu Ile Thr 
65                  70                  75                  80  


Leu Glu Leu Ile His Arg Tyr Val Glu Leu Leu Asp Lys Tyr Phe Gly 
                85                  90                  95      


Ser Val Cys Glu Leu Asp Ile Ile Phe Asn Phe Glu Lys Ala Tyr Phe 
            100                 105                 110         


Ile Leu Asp Glu Phe Leu Met Gly Gly Asp Val Gln Asp Thr Ser Lys 
        115                 120                 125             


Lys Ser Val Leu Lys Ala Ile Glu Gln Ala Asp Leu Leu Gln Glu Glu 
    130                 135                 140                 


Asp Glu Ser Pro Arg Ser Val Leu Glu Glu Met Gly Leu Ala 
145                 150                 155             


<210>  7962
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__BAA33391

<400>  7962
augaugcggu ucaugcuauu auucagccgg cagggaaaac ugcggcugca aaaaugguac       60

cuggccacuu cggacaagga acggaagaag auggugcgcg agcucaugca gguuguccug      120

gcucgaaagc ccaagaugug cagcuuccug gaguggaggg accucaaagu ugucuauaag      180

agauaugcca gccucuacuu cugcugcgcc aucgagggcc aagacaauga gcucaucaca      240

cuggagcuga uccaccgaua cguggagcuc uuagacaaau acuuuggcag ugugugcgag      300

cuggacauca ucuucaacuu ugagaaggcc uacuucaucc uggaugaguu uuugaugggg      360

ggggaugucc aggacaccuc caagaagagu gugcugaaag ccaucgagca ggcugaccua      420

cugcaagagg aggaugaguc gccacggagu gugcuggagg agauggguuu ggcauag         477


<210>  7963
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__BAA33391

<400>  7963
augaugcgcu ucaugcuccu guucagccgg cagggcaagc ugcgccugca gaagugguac       60

cucgccaccu ccgacaagga gcggaagaag auggugcgcg agcugaugca ggucgugcug      120

gcccggaagc ccaagaugug cagcuuccuc gaguggcgcg accugaaggu ggucuacaag      180

cgguacgcgu cccuguacuu cugcugcgcc aucgaggggc aggacaacga gcucaucacc      240

cuggagcuga uccaccgcua cguggagcuc cuggacaagu acuucggcag cgugugcgag      300

cuggacauca ucuucaacuu cgagaaggcc uacuucaucc ucgacgaguu ccugaugggc      360

ggggacgucc aggacacguc caagaagucc gugcugaagg ccaucgagca ggccgaccuc      420

cugcaggagg aggacgagag cccgcggagc gugcuggagg agauggggcu cgcguga         477


<210>  7964
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__BAA33391

<400>  7964
augaugcgcu ucaugcuccu cuucucccgc cagggcaagc uccgccucca gaagugguac       60

cucgccaccu ccgacaagga gcgcaagaag augguccgcg agcucaugca ggucguccuc      120

gcccgcaagc ccaagaugug cuccuuccuc gaguggcgcg accucaaggu cgucuacaag      180

cgcuacgccu cccucuacuu cugcugcgcc aucgagggcc aggacaacga gcucaucacc      240

cucgagcuca uccaccgcua cgucgagcuc cucgacaagu acuucggcuc cgucugcgag      300

cucgacauca ucuucaacuu cgagaaggcc uacuucaucc ucgacgaguu ccucaugggc      360

ggcgacgucc aggacaccuc caagaagucc guccucaagg ccaucgagca ggccgaccuc      420

cuccaggagg aggacgaguc cccccgcucc guccucgagg agaugggccu cgccuga         477


<210>  7965
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__BAA33391

<400>  7965
augaugagau ucaugcugcu cuuuagcagg cagggcaaac uucggcugca aaagugguac       60

uuggccaccu ccgacaagga gcgcaaaaag auggugcgag aauuaaugca ggucguucug      120

gcucguaaac ccaagaugug cucuuuccua gaguggagag aucucaaggu gguauauaaa      180

agguacgcau cacuguauuu uuguugcgcc aucgaagggc aggacaacga gcuuauuaca      240

cuggaauuga uacaccggua cguggagcuc cuggauaagu auuucggaag ugucugugag      300

cuggacauca uuuuuaauuu cgaaaaagcg uacuuuaucc ucgaugaguu cuuaaugggu      360

ggcgacgugc aggauacuag caagaaaucc guucugaagg cuauugaaca agccgaccuu      420

uugcaggagg aggaugaauc uccucgcucg gugcuggagg aaauggggcu agcauga         477


<210>  7966
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__BAA33391

<400>  7966
augaugagau ucaugcugcu guucagcaga cagggcaagc ugagacugca gaagugguac       60

cuggccacca gcgacaagga gagaaagaag auggugagag agcugaugca gguggugcug      120

gccagaaagc ccaagaugug cagcuuccug gaguggagag accugaaggu gguguacaag      180

agauacgcca gccuguacuu cugcugcgcc aucgagggcc aggacaacga gcugaucacc      240

cuggagcuga uccacagaua cguggagcug cuggacaagu acuucggcag cgugugcgag      300

cuggacauca ucuucaacuu cgagaaggcc uacuucaucc uggacgaguu ccugaugggc      360

ggcgacgugc aggacaccag caagaagagc gugcugaagg ccaucgagca ggccgaccug      420

cugcaggagg aggacgagag ccccagaagc gugcuggagg agaugggccu ggccuga         477


<210>  7967
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__BAA33391

<400>  7967
augaugagau ucaugcugcu cuuuagccgg cagggcaagc ugcgccuuca aaaaugguac       60

cuggccaccu ccgacaagga gcggaaaaag auggugagag aacucaugca ggucguucug      120

gcucgcaaac ccaagaugug cucuuuccuu gaguggagag aucugaaggu gguguauaaa      180

cgguacgcca gccucuauuu uuguugcgcg aucgaagggc aggacaacga gcugauuaca      240

cuggaacuca uccaccgcua cgucgagcug cuugauaagu auuucggauc cgugugugag      300

cuggacauua ucuuuaauuu cgaaaaagcc uacuuuauuc ucgaugaguu ccugaugggc      360

ggggacguuc aggauacguc uaagaaaagc gugcuuaagg cuaucgaaca agccgaccug      420

cuccaggagg aggaugaauc cccuagaucu guccuggagg aaaugggacu ggcuuga         477


<210>  7968
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__Q63HQ0

<400>  7968

Met Gly Asn Cys Cys Trp Thr Gln Cys Phe Gly Leu Leu Arg Lys Glu 
1               5                   10                  15      


Ala Gly Arg Leu Gln Arg Val Gly Gly Gly Gly Gly Ser Lys Tyr Phe 
            20                  25                  30          


Arg Thr Cys Ser Arg Gly Glu His Leu Thr Ile Glu Phe Glu Asn Leu 
        35                  40                  45              


Val Glu Ser Asp Glu Gly Glu Ser Pro Gly Ser Ser His Arg Pro Leu 
    50                  55                  60                  


Thr Glu Glu Glu Ile Val Asp Leu Arg Glu Arg His Tyr Asp Ser Ile 
65                  70                  75                  80  


Ala Glu Lys Gln Lys Asp Leu Asp Lys Lys Ile Gln Lys Glu Leu Ala 
                85                  90                  95      


Leu Gln Glu Glu Lys Leu Arg Leu Glu Glu Glu Ala Leu Tyr Ala Ala 
            100                 105                 110         


Gln Arg Glu Ala Ala Arg Ala Ala Lys Gln Arg Lys Leu Leu Glu Gln 
        115                 120                 125             


Glu Arg Gln Arg Ile Val Gln Gln Tyr His Pro Ser Asn Asn Gly Glu 
    130                 135                 140                 


Tyr Gln Ser Ser Gly Pro Glu Asp Asp Phe Glu Ser Cys Leu Arg Asn 
145                 150                 155                 160 


Met Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser Asp 
                165                 170                 175     


Ala Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met Thr 
            180                 185                 190         


Lys Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp Leu 
        195                 200                 205             


Glu Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg Glu 
    210                 215                 220                 


Arg Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr Ser 
225                 230                 235                 240 


Asn Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser Asn 
                245                 250                 255     


Gly Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp Asn 
            260                 265                 270         


Gly Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu Ser 
        275                 280                 285             


Asp Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg 
    290                 295                 300         


<210>  7969
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAY40962

<400>  7969
auggggaacu gcugcuggac gcagugcuuc ggacugcuuc gcaaggaagc ggggcggcug       60

cagcgaguag gcggcggcgg aggauccaag uauuuuagaa caugcucaag aggugagcac      120

uuaacaauag aguuugagaa ucuaguagaa agugaugaag gggagagccc aggaagcagu      180

cauaggccuc uuacugagga agaaauuguu gaccuaagag aaaggcauua ugauuccauu      240

gccgaaaaac aaaaagaucu ugauaagaaa auucaaaaag aguuagccuu acaagaagag      300

aaguuaagac uagaagaaga agcuuuauac gcugcacagc gugaagcagc cagggcagca      360

aagcagcgaa agcucuugga gcaagaaagg cagagaauug ugcagcaaua ucauccuucc      420

aacaauggag aauaucaaag uucaggacca gaagaugacu ucgaaucuug uuugagaaau      480

augaagucac aguaugaagu uuuucgaagu aguagacucu caucagaugc uacaguuuug      540

acaccaaaua cagaaagcag uugugauuua augaccaaaa cuaaaucaac uaguggaaau      600

gacgacagca cauccuuaga ucuagagugg gaagaugaag aaggaaugaa uagaaugcuu      660

ccaaugagag aacguuccaa aacagaggaa gacauucuac gggcagcacu uaaguauagc      720

aacaagaaga cuggaaguaa uccuacauca gccucugaug auuccaaugg gcuggagugg      780

gaaaaugauu uuguuagugc cgaaauggau gauaauggaa auuccgagua uucuggauuu      840

guaaauccug uauuagaacu gucugauucu ggcauaaggc auucugacac agaucaacag      900

acucgauag                                                              909


<210>  7970
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAY40962

<400>  7970
augggcaacu gcugcuggac ccagugcuuc gggcugcucc gcaaggaggc cggccggcug       60

cagcgcgucg ggggcggggg cggcagcaag uacuuccgga ccugcucccg cggggagcac      120

cugacgaucg aguucgagaa ccucguggag agcgacgagg gcgagucccc cgggagcucc      180

caccggccgc ugaccgagga ggagaucgug gaccugcgcg agcggcacua cgacagcauc      240

gccgagaagc agaaggaccu cgacaagaag auccagaagg agcuggcgcu gcaggaggag      300

aagcuccgcc uggaggagga ggcccuguac gccgcccagc gggaggccgc gcgcgccgcc      360

aagcagcgga agcuccugga gcaggagcgc cagcggaucg ugcagcagua ccaccccucc      420

aacaacggcg aguaccagag cuccgggccc gaggacgacu ucgagagcug ccugcgcaac      480

augaaguccc aguacgaggu cuuccggagc ucccgccuca gcuccgacgc caccgugcug      540

acccccaaca cggagagcuc cugcgaccug augaccaaga ccaagagcac cuccggcaac      600

gacgacagca cgagccucga ccuggagugg gaggacgagg agggcaugaa ccggaugcug      660

ccgaugcgcg agcgguccaa gaccgaggag gacauccucc gcgcggcccu gaaguacagc      720

aacaagaaga ccggguccaa ccccaccagc gccuccgacg acagcaacgg ccuggagugg      780

gagaacgacu ucguguccgc cgagauggac gacaacggga acagcgagua cuccggcuuc      840

gucaaccccg ugcucgagcu gagcgacucc ggcauccggc acagcgacac ggaccagcag      900

acccgcuga                                                              909


<210>  7971
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAY40962

<400>  7971
augggcaacu gcugcuggac ccagugcuuc ggccuccucc gcaaggaggc cggccgccuc       60

cagcgcgucg gcggcggcgg cggcuccaag uacuuccgca ccugcucccg cggcgagcac      120

cucaccaucg aguucgagaa ccucgucgag uccgacgagg gcgagucccc cggcuccucc      180

caccgccccc ucaccgagga ggagaucguc gaccuccgcg agcgccacua cgacuccauc      240

gccgagaagc agaaggaccu cgacaagaag auccagaagg agcucgcccu ccaggaggag      300

aagcuccgcc ucgaggagga ggcccucuac gccgcccagc gcgaggccgc ccgcgccgcc      360

aagcagcgca agcuccucga gcaggagcgc cagcgcaucg uccagcagua ccaccccucc      420

aacaacggcg aguaccaguc cuccggcccc gaggacgacu ucgaguccug ccuccgcaac      480

augaaguccc aguacgaggu cuuccgcucc ucccgccucu ccuccgacgc caccguccuc      540

acccccaaca ccgaguccuc cugcgaccuc augaccaaga ccaaguccac cuccggcaac      600

gacgacucca ccucccucga ccucgagugg gaggacgagg agggcaugaa ccgcaugcuc      660

cccaugcgcg agcgcuccaa gaccgaggag gacauccucc gcgccgcccu caaguacucc      720

aacaagaaga ccggcuccaa ccccaccucc gccuccgacg acuccaacgg ccucgagugg      780

gagaacgacu ucgucuccgc cgagauggac gacaacggca acuccgagua cuccggcuuc      840

gucaaccccg uccucgagcu cuccgacucc ggcauccgcc acuccgacac cgaccagcag      900

acccgcuga                                                              909


<210>  7972
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAY40962

<400>  7972
augggcaacu gcuguuggac ccagugcuuc gggcugcuca gaaaggaggc cggaaggcuu       60

caacgggugg guggcggggg aggcagcaaa uacuuucgca cauguucccg aggugaacac      120

cugacuaucg aguucgaaaa uuuggucgag ucugacgaag gggagucacc cggaaguagc      180

caucguccuu uaacggagga agagauuguu gaucugagag aaaggcacua ugacuccaua      240

gcugagaagc agaaagaucu agacaagaaa auccagaagg agcucgcacu gcaggaagag      300

aaacuucggc uggaagagga agccuuguac gcggcucaac gcgaggccgc aagagccgcu      360

aagcagagga agcuccugga gcaggaacgg cagcgcauug ugcaacagua ucauccaucu      420

aacaauggcg aguaccaguc gucaggcccg gaagaugacu uugagagcug ccugcgaaac      480

augaaaaguc aguaugaagu auucagaucc ucuaggcuca gcuccgaugc aaccguguua      540

acacccaaua cugagucaag uugugaccug augaccaaga caaaaagcac cucugggaac      600

gaugacucca cuucacuuga uuuggagugg gaagacgagg aaggaaugaa ucggaugcug      660

ccuaugcgug agcgcagcaa gacagaagag gauauccuaa gagccgcucu caaguacagu      720

aacaaaaaga ccgguucuaa uccaacgucc gccagcgacg acucgaacgg ccuggagugg      780

gaaaaugauu uugucucugc ggagauggac gauaacggaa auuccgaaua uucaggguuc      840

gugaaccccg uucuugagcu gagugacagc ggcauuaggc acuccgauac ugaccaacag      900

acccgguga                                                              909


<210>  7973
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAY40962

<400>  7973
augggcaacu gcugcuggac ccagugcuuc ggccugcuga gaaaggaggc cggcagacug       60

cagagagugg gcggcggcgg cggcagcaag uacuucagaa ccugcagcag aggcgagcac      120

cugaccaucg aguucgagaa ccugguggag agcgacgagg gcgagagccc cggcagcagc      180

cacagacccc ugaccgagga ggagaucgug gaccugagag agagacacua cgacagcauc      240

gccgagaagc agaaggaccu ggacaagaag auccagaagg agcuggcccu gcaggaggag      300

aagcugagac uggaggagga ggcccuguac gccgcccaga gagaggccgc cagagccgcc      360

aagcagagaa agcugcugga gcaggagaga cagagaaucg ugcagcagua ccaccccagc      420

aacaacggcg aguaccagag cagcggcccc gaggacgacu ucgagagcug ccugagaaac      480

augaagagcc aguacgaggu guucagaagc agcagacuga gcagcgacgc caccgugcug      540

acccccaaca ccgagagcag cugcgaccug augaccaaga ccaagagcac cagcggcaac      600

gacgacagca ccagccugga ccuggagugg gaggacgagg agggcaugaa cagaaugcug      660

cccaugagag agagaagcaa gaccgaggag gacauccuga gagccgcccu gaaguacagc      720

aacaagaaga ccggcagcaa ccccaccagc gccagcgacg acagcaacgg ccuggagugg      780

gagaacgacu ucgugagcgc cgagauggac gacaacggca acagcgagua cagcggcuuc      840

gugaaccccg ugcuggagcu gagcgacagc ggcaucagac acagcgacac cgaccagcag      900

accagauga                                                              909


<210>  7974
<211>  909
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAY40962

<400>  7974
augggcaacu gcuguuggac ccagugcuuc gggcugcuca gaaaggaggc cggacggcug       60

caacgcgugg gcgggggagg cgggagcaaa uacuuuagaa cauguucccg gggagaacac      120

cuuacgaucg aguucgaaaa ucuggucgag ucugacgaag gcgagagccc cggcuccucu      180

caucgcccuc ucaccgagga agagauuguu gaucugagag aacggcacua ugacagcauc      240

gcugagaagc agaaagaucu ugacaagaaa auucagaagg agcuggcccu ccaggaagag      300

aagcugcgcc uggaagagga agcgcucuac gcugcccaaa gagaggccgc ucgggccgcu      360

aaacagcgca agcugcuuga gcaggaaaga cagcggaucg ugcaacagua ucauccgucc      420

aacaaugggg aguaccaguc uagcggaccc gaagaugacu uugaguccug ccugcgcaac      480

augaaaagcc aguaugaagu guucagaucu ucccggcuca gcucugaugc cacaguccug      540

accccuaaua cagaguccag cugugaccuu augaccaaga caaaaucuac cuccggcaac      600

gaugacagca cgucccugga ucucgagugg gaagacgagg aagggaugaa ucgcaugcug      660

cccaugagag agcggucuaa gaccgaagag gauauucuga gagcggcccu caaguacagc      720

aacaaaaaga caggauccaa uccuaccagc gcuucugacg acuccaacgg ccuggagugg      780

gaaaaugauu uugugagcgc cgagauggac gauaacggaa auucugaaua uagcggguuc      840

guuaaccccg ugcuugagcu guccgacucu ggcauccgcc acagcgauac agaccaacag      900

acccgguga                                                              909


<210>  7975
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__Q7Z5Q8

<400>  7975

Met Leu Gly Thr Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr Ala 
1               5                   10                  15      


Leu Met Val Ser Cys Asn Arg Leu Trp Val Gly Thr Gly Asn Gly Val 
            20                  25                  30          


Ile Ile Ser Ile Pro Leu Thr Glu Thr Val Ile Leu His Gln Gly Arg 
        35                  40                  45              


Leu Leu Gly Leu Arg Ala Asn Lys Thr Ser Gly Val Pro Gly Asn Arg 
    50                  55                  60                  


Pro Gly Ser Val Ile Arg Val Tyr Gly Asp Glu Asn Ser Asp Lys Val 
65                  70                  75                  80  


Thr Pro Gly Thr Phe Ile Pro Tyr Cys Ser Met Ala His Ala Gln Leu 
                85                  90                  95      


Cys Phe His Gly His Arg Asp Ala Val Lys Phe Phe Val Ala Val Pro 
            100                 105                 110         


Gly Gln Val Ile Ser Pro Gln Ser Ser Ser Ser Gly Thr Asp Leu Thr 
        115                 120                 125             


Gly Asp Lys Ala Gly Pro Ser Ala Gln Glu Pro Gly Ser Gln Thr Pro 
    130                 135                 140                 


Leu Lys Ser Met Leu Val Ile Ser Gly Gly Glu Gly Tyr Ile Asp Phe 
145                 150                 155                 160 


Arg Met Gly Asp Glu Gly Gly Glu Ser Glu Leu Leu Gly Glu Asp Leu 
                165                 170                 175     


Pro Leu Glu Pro Ser Val Thr Lys Ala Glu Arg Ser His Leu Ile Val 
            180                 185                 190         


Trp Gln Val Met Tyr Gly Asn Glu 
        195                 200 


<210>  7976
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAN12270

<400>  7976
auguuaggua cuggaaaacu gggcuucucu uuugugagaa uuacagcucu uauggugucu       60

uguaaucguu uguggguggg gacaggaaau ggugucauua ucuccauccc auugacagaa      120

accguaaucc uccaccaggg acguuuacug gggcugaggg caaauaaaac cucaggugua      180

ccaggaaauc guccuggaag uguaauccgu guauauggug augaaaacag ugauaaagug      240

acuccaggga cauuuauacc cuauuguuca auggcacaug cacagcuuug cuuccauggg      300

caccgggaug cugugaaauu cuuuguggca gucccagguc aagucaucag cccacaaagu      360

agcaguagug gcacggaucu gacgggugac aaagcagggc caucugcaca ggagccuggu      420

agucagacgc ccuugaaguc uaugcuuguc aucaguggag gagagggcua caucgacuuc      480

cgaaugggug augaaggugg agaaucagaa cuucuuggag aggaucuucc acuugaaccu      540

ucugucacca aagcagaaag gagucacuug auaguguggc aagugaugua uggcaaugag      600

uga                                                                    603


<210>  7977
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAN12270

<400>  7977
augcugggca ccgggaagcu cggcuucagc uucgugcgca ucaccgcccu gauggucucc       60

ugcaaccggc uguggguggg gacgggcaac ggggugauca ucagcauccc ccucaccgag      120

accgucaucc ugcaccaggg ccgccugcuc ggccugcggg ccaacaagac cuccggggug      180

ccgggcaacc gccccgggag cgugauccgg gucuacggcg acgagaacuc cgacaaggug      240

acgcccggga ccuucauccc cuacugcagc auggcgcacg cccagcugug cuuccacggc      300

caccgcgacg ccgugaaguu cuucgucgcc gugccgggcc aggugaucag cccccagagc      360

uccagcuccg ggaccgaccu caccggcgac aaggccgggc ccagcgcgca ggagcccggc      420

ucccagacgc cgcugaaguc caugcugguc aucuccggcg gggagggcua caucgacuuc      480

cggauggggg acgagggcgg ggagagcgag cuccugggcg aggaccugcc ccucgagccc      540

uccgugacca aggccgagcg cagccaccug aucguguggc aggucaugua cggcaacgag      600

uga                                                                    603


<210>  7978
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAN12270

<400>  7978
augcucggca ccggcaagcu cggcuucucc uucguccgca ucaccgcccu cauggucucc       60

ugcaaccgcc ucugggucgg caccggcaac ggcgucauca ucuccauccc ccucaccgag      120

accgucaucc uccaccaggg ccgccuccuc ggccuccgcg ccaacaagac cuccggcguc      180

cccggcaacc gccccggcuc cgucauccgc gucuacggcg acgagaacuc cgacaagguc      240

acccccggca ccuucauccc cuacugcucc auggcccacg cccagcucug cuuccacggc      300

caccgcgacg ccgucaaguu cuucgucgcc guccccggcc aggucaucuc cccccagucc      360

uccuccuccg gcaccgaccu caccggcgac aaggccggcc ccuccgccca ggagcccggc      420

ucccagaccc cccucaaguc caugcucguc aucuccggcg gcgagggcua caucgacuuc      480

cgcaugggcg acgagggcgg cgaguccgag cuccucggcg aggaccuccc ccucgagccc      540

uccgucacca aggccgagcg cucccaccuc aucgucuggc aggucaugua cggcaacgag      600

uga                                                                    603


<210>  7979
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAN12270

<400>  7979
augcugggca ccgggaagcu cggauucagc uuugugagaa ucacagcccu uauggucucc       60

ugcaacaggc uguggguugg uacuggcaau ggggugauua uaucuauccc cuugacggag      120

accguaauuu uacaccaggg acggcugcua ggccuccgcg cuaacaaaac aucaggugug      180

ccugggaauc gaccaggaag ugucauccgu guguacggcg acgaaaacag cgauaagguu      240

acuccgggca ccuucauucc cuauuguucc auggcacaug cccagcugug cuuucacggg      300

cauagagacg cggugaaauu cuuugucgcu gugccuggac agguaaucuc uccacagucg      360

ucaagcagug guacagaucu uaccggcgac aaggccgggc ccuccgcaca ggagccugga      420

ucucaaacuc cacugaaaag cauguugguu auauccggcg gugaagggua caucgauuuc      480

aggaugggag acgagggcgg cgaaucagag cuccuggggg aggaucugcc ccucgaaccu      540

agugugacaa aggccgagcg gagccacuua auugucuggc aagugaugua uggaaaugaa      600

uga                                                                    603


<210>  7980
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAN12270

<400>  7980
augcugggca ccggcaagcu gggcuucagc uucgugagaa ucaccgcccu gauggugagc       60

ugcaacagac uguggguggg caccggcaac ggcgugauca ucagcauccc ccugaccgag      120

accgugaucc ugcaccaggg cagacugcug ggccugagag ccaacaagac cagcggcgug      180

cccggcaaca gacccggcag cgugaucaga guguacggcg acgagaacag cgacaaggug      240

acccccggca ccuucauccc cuacugcagc auggcccacg cccagcugug cuuccacggc      300

cacagagacg ccgugaaguu cuucguggcc gugcccggcc aggugaucag cccccagagc      360

agcagcagcg gcaccgaccu gaccggcgac aaggccggcc ccagcgccca ggagcccggc      420

agccagaccc cccugaagag caugcuggug aucagcggcg gcgagggcua caucgacuuc      480

agaaugggcg acgagggcgg cgagagcgag cugcugggcg aggaccugcc ccuggagccc      540

agcgugacca aggccgagag aagccaccug aucguguggc aggugaugua cggcaacgag      600

uga                                                                    603


<210>  7981
<211>  603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAN12270

<400>  7981
augcugggca ccgggaagcu cggauucagc uuugugagaa ucacagcccu gauggucucc       60

ugcaaccggc uuuggguugg cacggggaau ggagugauua ucucuauucc ccugaccgag      120

acagugaucc uccaccaggg ccgccugcuu gggcugagag cuaacaaaac cagcggaguc      180

ccuggcaauc ggccgggcuc cgugauucgc guuuacgggg acgaaaacuc ugauaaggug      240

acacccggaa ccuucauccc uuauuguagc auggcccaug cgcaacucug cuuucacggc      300

cauagagacg cugucaaauu cuuuguggcc guucccggac aggugaucuc cccucagucu      360

agcuccagcg ggacagaucu gaccggcgac aaggccgggc ccucugcuca ggagccugga      420

ucccaaacgc cgcugaaaag caugcucguc auuucuggcg gcgaagggua caucgauuuc      480

cggaugggag acgagggcgg ggaauccgag cugcuuggag aggaucugcc ccucgaaccu      540

agcgugacca aggccgagcg cucucaccug auuguguggc aggucaugua uggcaaugaa      600

uga                                                                    603


<210>  7982
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__Q96PC3

<400>  7982

Met Ile His Phe Ile Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu 
1               5                   10                  15      


Gln Lys Trp Tyr Ile Thr Leu Pro Asp Lys Glu Arg Lys Lys Ile Thr 
            20                  25                  30          


Arg Glu Ile Val Gln Ile Ile Leu Ser Arg Gly His Arg Thr Ser Ser 
        35                  40                  45              


Phe Val Asp Trp Lys Glu Leu Lys Leu Val Tyr Lys Arg Tyr Ala Ser 
    50                  55                  60                  


Leu Tyr Phe Cys Cys Ala Ile Glu Asn Gln Asp Asn Glu Leu Leu Thr 
65                  70                  75                  80  


Leu Glu Ile Val His Arg Tyr Val Glu Leu Leu Asp Lys Tyr Phe Gly 
                85                  90                  95      


Asn Val Cys Glu Leu Asp Ile Ile Phe Asn Phe Glu Lys Ala Tyr Phe 
            100                 105                 110         


Ile Leu Asp Glu Phe Ile Ile Gly Gly Glu Ile Gln Glu Thr Ser Lys 
        115                 120                 125             


Lys Ile Ala Val Lys Ala Ile Glu Asp Ser Asp Met Leu Gln Glu Val 
    130                 135                 140                 


Ser Thr Val Ser Gln Thr Met Gly Glu Arg 
145                 150                 


<210>  7983
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAL09586

<400>  7983
augauacauu ucauauugcu cuucagucga caagggaaau uacggcuaca gaaaugguac       60

aucacucucc cugauaaaga gaggaagaag aucacccggg aaauuguuca gauuauucuc      120

ucccgugguc acaggacaag caguuuuguu gacuggaagg agcuaaaacu uguuuauaaa      180

agguaugcua guuuauauuu uugcugugca auagaaaauc aggacaauga gcucuugacg      240

cuagagauug ugcaucguua cguggagcug cuggacaaau auuuuggaaa ugucugugag      300

cuggauauua ucuuuaauuu ugaaaaggcu uauuucaucc uggacgaguu uauaauaggu      360

ggggaaauuc aggaaacauc caagaaaauu gcugucaaag ccauugaaga cucugauaug      420

uuacaggagg ucaguacggu uucccaaacc augggagaaa gauga                      465


<210>  7984
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAL09586

<400>  7984
augauccacu ucauccuccu guucagccgc cagggcaagc ugcggcugca gaagugguac       60

aucacccucc ccgacaagga gcgcaagaag aucacccggg agaucgugca gaucauccug      120

ucccgcgggc accggacgag cuccuucguc gacuggaagg agcugaagcu cguguacaag      180

cgcuacgcca gccuguacuu cugcugcgcc aucgagaacc aggacaacga gcugcucacc      240

cuggagaucg ugcaccggua cgucgagcug cucgacaagu acuucggcaa cgugugcgag      300

cuggacauca ucuucaacuu cgagaaggcg uacuucaucc uggacgaguu caucaucggg      360

ggcgagaucc aggagaccuc caagaagauc gccgugaagg ccaucgagga cagcgacaug      420

cuccaggagg ucuccaccgu gagccagacg augggggagc gcuga                      465


<210>  7985
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAL09586

<400>  7985
augauccacu ucauccuccu cuucucccgc cagggcaagc uccgccucca gaagugguac       60

aucacccucc ccgacaagga gcgcaagaag aucacccgcg agaucgucca gaucauccuc      120

ucccgcggcc accgcaccuc cuccuucguc gacuggaagg agcucaagcu cgucuacaag      180

cgcuacgccu cccucuacuu cugcugcgcc aucgagaacc aggacaacga gcuccucacc      240

cucgagaucg uccaccgcua cgucgagcuc cucgacaagu acuucggcaa cgucugcgag      300

cucgacauca ucuucaacuu cgagaaggcc uacuucaucc ucgacgaguu caucaucggc      360

ggcgagaucc aggagaccuc caagaagauc gccgucaagg ccaucgagga cuccgacaug      420

cuccaggagg ucuccaccgu cucccagacc augggcgagc gcuga                      465


<210>  7986
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAL09586

<400>  7986
augauccacu ucauucugcu cuuuagcaga cagggcaaac uuaggcugca aaagugguac       60

auaaccuugc ccgacaagga gcggaaaaag aucacacgcg aaauugugca gaucauuuua      120

ucccgagggc aucguacuuc uucauucguc gauuggaaag agcugaagcu aguuuauaag      180

agauacgcca gucucuauuu uugcugugcu aucgaaaacc aggacaauga gcugcuuacg      240

cuggaaauag ugcacaggua cguagaguug cucgauaaau auuucggaaa cgugugcgag      300

cuggacauca uuuuuaauuu cgaaaaggca uacuuuaucc uggaugaguu cauuaucggu      360

ggcgaaauac aggagaccag caaaaagauu gccgucaaag cgaucgagga cuccgauaug      420

cuccaagaag ugucuacagu uucgcagacu augggggagc gguga                      465


<210>  7987
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAL09586

<400>  7987
augauccacu ucauccugcu guucagcaga cagggcaagc ugagacugca gaagugguac       60

aucacccugc ccgacaagga gagaaagaag aucaccagag agaucgugca gaucauccug      120

agcagaggcc acagaaccag cagcuucgug gacuggaagg agcugaagcu gguguacaag      180

agauacgcca gccuguacuu cugcugcgcc aucgagaacc aggacaacga gcugcugacc      240

cuggagaucg ugcacagaua cguggagcug cuggacaagu acuucggcaa cgugugcgag      300

cuggacauca ucuucaacuu cgagaaggcc uacuucaucc uggacgaguu caucaucggc      360

ggcgagaucc aggagaccag caagaagauc gccgugaagg ccaucgagga cagcgacaug      420

cugcaggagg ugagcaccgu gagccagacc augggcgaga gauga                      465


<210>  7988
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAL09586

<400>  7988
augauccacu ucauucugcu cuuuagcaga cagggcaagc ugcggcuuca aaaaugguac       60

aucacccugc ccgacaagga gcgcaaaaag auuacaagag aaaucgugca gauuauccuc      120

ucccgggggc aucgcacguc uagcuucguc gauuggaaag agcugaaacu uguuuauaag      180

agauacgccu cccuguauuu uugcugugcu aucgaaaacc aggacaauga gcuccugacc      240

cuggaaauug ugcaccggua cguggagcuc cuggauaagu auuucggaaa cgucugcgag      300

cuugacauca uuuuuaauuu cgaaaaggcc uacuuuaucc uggaugaguu cauuaucggc      360

ggggaaauuc aggagacauc uaaaaagauc gcggugaaag cuaucgagga cagcgauaug      420

cuccaagaag uuuccaccgu gucucagaca augggagagc gcuga                      465


<210>  7989
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__Q9BXS5

<400>  7989

Met Ser Ala Ser Ala Val Tyr Val Leu Asp Leu Lys Gly Lys Val Leu 
1               5                   10                  15      


Ile Cys Arg Asn Tyr Arg Gly Asp Val Asp Met Ser Glu Val Glu His 
            20                  25                  30          


Phe Met Pro Ile Leu Met Glu Lys Glu Glu Glu Gly Met Leu Ser Pro 
        35                  40                  45              


Ile Leu Ala His Gly Gly Val Arg Phe Met Trp Ile Lys His Asn Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Ser Lys Lys Asn Ala Cys Val Ser Leu Val 
65                  70                  75                  80  


Phe Ser Phe Leu Tyr Lys Val Val Gln Val Phe Ser Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Ile Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Tyr Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Glu Gly His Lys Leu Glu Thr 
    130                 135                 140                 


Gly Ala Pro Arg Pro Pro Ala Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Arg Lys Asn Glu Val Phe Leu Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Val Ser Ala Asn Gly Asn Val Leu Arg Ser 
            180                 185                 190         


Glu Ile Val Gly Ser Ile Lys Met Arg Val Phe Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Leu Arg Leu Gly Leu Asn Asp Lys Val Leu Phe Asp Asn Thr Gly 
    210                 215                 220                 


Arg Gly Lys Ser Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln 
225                 230                 235                 240 


Cys Val Arg Leu Ser Arg Phe Glu Asn Asp Arg Thr Ile Ser Phe Ile 
                245                 250                 255     


Pro Pro Asp Gly Glu Phe Glu Leu Met Ser Tyr Arg Leu Asn Thr His 
            260                 265                 270         


Val Lys Pro Leu Ile Trp Ile Glu Ser Val Ile Glu Lys His Ser His 
        275                 280                 285             


Ser Arg Ile Glu Tyr Met Ile Lys Ala Lys Ser Gln Phe Lys Arg Arg 
    290                 295                 300                 


Ser Thr Ala Asn Asn Val Glu Ile His Ile Pro Val Pro Asn Asp Ala 
305                 310                 315                 320 


Asp Ser Pro Lys Phe Lys Thr Thr Val Gly Ser Val Lys Trp Val Pro 
                325                 330                 335     


Glu Asn Ser Glu Ile Val Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys 
            340                 345                 350         


Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Ala Glu 
        355                 360                 365             


Asp Lys Glu Gly Lys Pro Pro Ile Ser Val Lys Phe Glu Ile Pro Tyr 
    370                 375                 380                 


Phe Thr Thr Ser Gly Ile Gln Val Arg Tyr Leu Lys Ile Ile Glu Lys 
385                 390                 395                 400 


Ser Gly Tyr Gln Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Asn Gly 
                405                 410                 415     


Asp Tyr Gln Leu Arg Thr Gln 
            420             


<210>  7990
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAK28024

<400>  7990
auguccgcca gcgccgucua cgugcuggac cugaagggca aggugcucau cugccggaac       60

uaccguggcg acguggacau gucagaggug gagcacuuca ugcccauccu gauggagaag      120

gaggaggagg ggaugcuguc gcccauccug gcccacgggg ggguccguuu cauguggauc      180

aaacacaaca accuguaucu gguugccaca uccaagaaga acgcgugcgu gucgcugguc      240

uuuucuuucc ucuauaaggu ggugcaggug uuuuccgagu acuucaagga gcuggaggag      300

gagagcaucc gggacaacuu uguuaucauc uacgagcugc uggacgagcu cauggacuuc      360

ggcuaccccc agaccaccga cagcaagauc cugcaggagu acaucacuca ggaaggccac      420

aagcuggaaa caggggcccc gcggccacca gccaccguca ccaacgcggu guccuggcgg      480

uccgaaggca ucaaguaucg gaagaaugag guguucuugg acgucaucga gucugucaac      540

cucuugguca gcgccaacgg caauguccug cgcagcgaga ucgugggcuc caucaagaug      600

cgagucuucc ucucgggcau gcccgagcug cgccugggcc ucaacgacaa gguccucuuu      660

gacaacacgg gccgcggcaa aagcaaaucc guggagcugg aggaugugaa guuccaccag      720

ugugugcggc uaucacgcuu cgagaaugac cgcaccaucu ccuucauccc acccgacggc      780

gaguucgagc ucauguccua ccggcucaac acccacguca agccuuugau auggaucgag      840

ucggugaucg agaagcacuc ccacagccgc aucgaguaca ugaucaaggc caaaagccag      900

uucaagcggc ggucaacagc caacaacgug gagauccaca uucccgugcc caaugaugcc      960

gacucaccca aguucaagac gacggugggg agcguuaagu ggguccccga gaacagcgag     1020

aucguguggu ccaucaaguc cuucccgggc ggcaaggagu accugaugcg ggcccacuuc     1080

ggccugccua guguggaggc cgaagacaag gagggcaagc ccccgaucag ugucaaguuc     1140

gagaucccuu acuucacuac cuccggcauc caggugcgcu accugaagau cauugagaag     1200

aguggguacc aggcccugcc cugggugcgu uauaucacgc agaauggaga uuaccagcuc     1260

cggacccagu ga                                                         1272


<210>  7991
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAK28024

<400>  7991
augagcgcca gcgccgugua cguccuggac cucaagggca aggugcugau cugccgcaac       60

uaccgcgggg acguggacau gagcgagguc gagcacuuca ugcccauccu gauggagaag      120

gaggaggagg gcaugcucuc cccgauccug gcgcacgggg gcgugcgcuu cauguggauc      180

aagcacaaca accuguaccu cguggccacc agcaagaaga acgccugcgu cucccuggug      240

uucagcuucc uguacaaggu gguccaggug uucuccgagu acuucaagga gcucgaggag      300

gagagcaucc gggacaacuu cgugaucauc uacgagcugc uggacgagcu cauggacuuc      360

ggguaccccc agaccacgga cuccaagauc cugcaggagu acaucaccca ggagggccac      420

aagcuggaga ccggcgcgcc ccggcccccg gccaccguca cgaacgccgu gagcuggcgg      480

uccgagggga ucaaguaccg caagaacgag guguuccucg acgucaucga gagcgugaac      540

cugcuggugu ccgccaacgg caacguccuc cggagcgaga ucgugggguc caucaagaug      600

cgcguguucc ugagcggcau gcccgagcug cggcucgggc ugaacgacaa gguccuguuc      660

gacaacaccg gccgcggcaa guccaagagc guggagcucg aggacgugaa guuccaccag      720

ugcguccggc ugucccgcuu cgagaacgac cggaccauca gcuucauccc gcccgacggg      780

gaguucgagc ugaugagcua ccgccucaac acccacguga agccccugau cuggaucgag      840

uccgucaucg agaagcacag ccacucccgg aucgaguaca ugaucaaggc caagagccag      900

uucaagcgcc gguccacggc caacaacgug gagauccaca uccccgugcc caacgacgcg      960

gacagcccca aguucaagac caccgucggc uccgugaagu gggugccgga gaacagcgag     1020

aucgucuggu ccaucaagag cuuccccggg ggcaaggagu accugaugcg cgcccacuuc     1080

ggccuccccu ccguggaggc cgaggacaag gaggggaagc ccccgaucag cgugaaguuc     1140

gagauccccu acuucaccac guccggcauc cagguccggu accugaagau caucgagaag     1200

uccggguacc aggcccugcc cugggugcgc uacaucaccc agaacggcga cuaccagcuc     1260

cggacccagu ga                                                         1272


<210>  7992
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAK28024

<400>  7992
auguccgccu ccgccgucua cguccucgac cucaagggca agguccucau cugccgcaac       60

uaccgcggcg acgucgacau guccgagguc gagcacuuca ugcccauccu cauggagaag      120

gaggaggagg gcaugcucuc ccccauccuc gcccacggcg gcguccgcuu cauguggauc      180

aagcacaaca accucuaccu cgucgccacc uccaagaaga acgccugcgu cucccucguc      240

uucuccuucc ucuacaaggu cguccagguc uucuccgagu acuucaagga gcucgaggag      300

gaguccaucc gcgacaacuu cgucaucauc uacgagcucc ucgacgagcu cauggacuuc      360

ggcuaccccc agaccaccga cuccaagauc cuccaggagu acaucaccca ggagggccac      420

aagcucgaga ccggcgcccc ccgccccccc gccaccguca ccaacgccgu cuccuggcgc      480

uccgagggca ucaaguaccg caagaacgag gucuuccucg acgucaucga guccgucaac      540

cuccucgucu ccgccaacgg caacguccuc cgcuccgaga ucgucggcuc caucaagaug      600

cgcgucuucc ucuccggcau gcccgagcuc cgccucggcc ucaacgacaa gguccucuuc      660

gacaacaccg gccgcggcaa guccaagucc gucgagcucg aggacgucaa guuccaccag      720

ugcguccgcc ucucccgcuu cgagaacgac cgcaccaucu ccuucauccc ccccgacggc      780

gaguucgagc ucauguccua ccgccucaac acccacguca agccccucau cuggaucgag      840

uccgucaucg agaagcacuc ccacucccgc aucgaguaca ugaucaaggc caagucccag      900

uucaagcgcc gcuccaccgc caacaacguc gagauccaca uccccguccc caacgacgcc      960

gacuccccca aguucaagac caccgucggc uccgucaagu ggguccccga gaacuccgag     1020

aucgucuggu ccaucaaguc cuuccccggc ggcaaggagu accucaugcg cgcccacuuc     1080

ggccuccccu ccgucgaggc cgaggacaag gagggcaagc cccccaucuc cgucaaguuc     1140

gagauccccu acuucaccac cuccggcauc cagguccgcu accucaagau caucgagaag     1200

uccggcuacc aggcccuccc cuggguccgc uacaucaccc agaacggcga cuaccagcuc     1260

cgcacccagu ga                                                         1272


<210>  7993
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAK28024

<400>  7993
augagcgccu ccgcugugua cguccuggac cucaagggca aaguucuuau cugcagaaac       60

uauaggggag auguggacau gucugaggua gaacacuuca ugcccauucu gauggagaag      120

gaagaggaag ggauguuguc accuauauua gcacauggug gcgugcgguu uauguggauc      180

aaacacaaua accuguaccu agucgccacc aguaagaaaa augcgugugu gagccucguu      240

uucuccuuuc uguauaaggu gguccaggug uucucugagu acuuuaagga gcuugaagag      300

gaaucgauuc gcgauaacuu cguaaucauu uaugagcugu uggacgagcu cauggauuuu      360

ggguacccac aaacaacuga cucaaaaauc cugcaggaau auauaacgca ggagggacau      420

aagcuggaaa ccggcgcucc gcgacccccu gccacaguua cuaaugcagu gagcuggcgu      480

agugagggua ucaaauacag aaagaacgaa gucuuccucg augugauuga guccgugaau      540

uuacuggucu cugccaacgg gaauguucuu aggagcgaga ucgugggauc cauuaaaaug      600

cggguauuuu ugucaggcau gccagaacug cgccuaggcc ucaacgacaa ggugcuguuc      660

gauaauaccg ggagaggaaa gaguaaaagc gucgagcuug aagacgugaa guuucaccag      720

ugcguuaggc ugucucgguu cgagaacgau cgcacaaucu ccuuuauacc cccugacggu      780

gaguucgaau ugaugucaua ccgacucaau acccauguga aaccacugau uuggaucgag      840

agcgucauug aaaagcacag ucacucuaga aucgaguaua ugaucaaagc uaagucccaa      900

uucaaaaggc ggagcacugc aaacaaugug gaaauucaua uacccguacc uaacgaugcc      960

gacucgccaa aguuuaagac aaccguuggc ucugugaaau gggucccgga gaacuccgaa     1020

aucguguggu caauuaagag uuuccccggg ggaaaagagu acuuaaugcg ugcucacuuu     1080

ggccugccua gcgucgaggc cgaagacaag gaggguaaac cacccaucuc cgugaaguuc     1140

gaaauaccuu auuuuacgac uucugggauu cagguucgcu accucaagau caucgagaaa     1200

agcggauauc aggcgcuucc augggugaga uacauuaccc agaauggcga uuaucaacug     1260

aggacacagu ga                                                         1272


<210>  7994
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAK28024

<400>  7994
augagcgcca gcgccgugua cgugcuggac cugaagggca aggugcugau cugcagaaac       60

uacagaggcg acguggacau gagcgaggug gagcacuuca ugcccauccu gauggagaag      120

gaggaggagg gcaugcugag ccccauccug gcccacggcg gcgugagauu cauguggauc      180

aagcacaaca accuguaccu gguggccacc agcaagaaga acgccugcgu gagccuggug      240

uucagcuucc uguacaaggu ggugcaggug uucagcgagu acuucaagga gcuggaggag      300

gagagcauca gagacaacuu cgugaucauc uacgagcugc uggacgagcu gauggacuuc      360

ggcuaccccc agaccaccga cagcaagauc cugcaggagu acaucaccca ggagggccac      420

aagcuggaga ccggcgcccc cagacccccc gccaccguga ccaacgccgu gagcuggaga      480

agcgagggca ucaaguacag aaagaacgag guguuccugg acgugaucga gagcgugaac      540

cugcugguga gcgccaacgg caacgugcug agaagcgaga ucgugggcag caucaagaug      600

agaguguucc ugagcggcau gcccgagcug agacugggcc ugaacgacaa ggugcuguuc      660

gacaacaccg gcagaggcaa gagcaagagc guggagcugg aggacgugaa guuccaccag      720

ugcgugagac ugagcagauu cgagaacgac agaaccauca gcuucauccc ccccgacggc      780

gaguucgagc ugaugagcua cagacugaac acccacguga agccccugau cuggaucgag      840

agcgugaucg agaagcacag ccacagcaga aucgaguaca ugaucaaggc caagagccag      900

uucaagagaa gaagcaccgc caacaacgug gagauccaca uccccgugcc caacgacgcc      960

gacagcccca aguucaagac caccgugggc agcgugaagu gggugcccga gaacagcgag     1020

aucgugugga gcaucaagag cuuccccggc ggcaaggagu accugaugag agcccacuuc     1080

ggccugccca gcguggaggc cgaggacaag gagggcaagc cccccaucag cgugaaguuc     1140

gagauccccu acuucaccac cagcggcauc caggugagau accugaagau caucgagaag     1200

agcggcuacc aggcccugcc cugggugaga uacaucaccc agaacggcga cuaccagcug     1260

agaacccagu ga                                                         1272


<210>  7995
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAK28024

<400>  7995
augagcgccu ccgcugugua cguccuggac cucaagggca aaguucugau cugcagaaac       60

uaucgcgggg auguggacau gucugaggug gaacacuuca ugcccauucu uauggagaag      120

gaagaggaag gaaugcugag cccuauccuc gcccauggcg ggguccgguu uauguggauu      180

aaacacaaua accuguaccu uguggcgacc uccaagaaaa augcuugugu uucucuggug      240

uucagcuuuc ucuauaaggu cgugcagguu uucuccgagu acuuuaagga gcuggaagag      300

gaaucuauca gagauaacuu cgugauuauc uaugagcugc ucgacgagcu gauggauuuu      360

ggauacccgc aaacaacgga cagcaaaauc cuucaggaau auauuaccca ggagggccau      420

aagcuggaaa caggggcucc ccggccuccc gccaccguca caaaugccgu guccuggcgc      480

agcgagggaa ucaaauacag aaagaacgaa guguuccucg augucauuga gucuguuaau      540

cugcuugugu ccgccaacgg caaugugcug cggagcgaga ucgucggcuc uauuaaaaug      600

cgcguguuuc ucuccgggau gccugaacug agacugggac ucaacgacaa gguucuguuc      660

gauaauaccg gccggggaaa gagcaaaucu guggagcuug aagacgucaa guuucaccag      720

ugcgugcgcc uguccagauu cgagaacgau cggacaauca gcuuuauucc cccugacggg      780

gaguucgaac ucauguccua ccgccugaau acccauguua aaccgcuuau cuggaucgag      840

ucugugauug aaaagcacag ccacuccaga aucgaguaua ugauuaaagc uaagagccaa      900

uucaaacggc gcucuacggc caacaauguc gaaauccaua uucccgugcc uaacgaugcg      960

gacuccccca aguuuaagac cacagucggc agcgugaaau ggguuccuga gaacucugaa     1020

aucgugugga gcaucaaguc cuuccccggg ggaaaagagu accugaugag agcccacuuu     1080

ggccucccgu cugucgaggc ugaagacaag gagggcaaac cucccauuag cgugaaguuc     1140

gaaaucccuu auuuuaccac auccgggauu cagguucggu accugaagau cauugagaaa     1200

agcggauauc aggcccugcc cugggugaga uacaucaccc agaauggcga uuaucaacuc     1260

cgcacgcagu ga                                                         1272


<210>  7996
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__Q9Y6Q5

<400>  7996

Met Ser Ala Ser Ala Val Phe Ile Leu Asp Val Lys Gly Lys Pro Leu 
1               5                   10                  15      


Ile Ser Arg Asn Tyr Lys Gly Asp Val Ala Met Ser Lys Ile Glu His 
            20                  25                  30          


Phe Met Pro Leu Leu Val Gln Arg Glu Glu Glu Gly Ala Leu Ala Pro 
        35                  40                  45              


Leu Leu Ser His Gly Gln Val His Phe Leu Trp Ile Lys His Ser Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Thr Ser Lys Asn Ala Asn Ala Ser Leu Val 
65                  70                  75                  80  


Tyr Ser Phe Leu Tyr Lys Thr Ile Glu Val Phe Cys Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Val Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Phe Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Gln Ser Asn Lys Leu Glu Thr 
    130                 135                 140                 


Gly Lys Ser Arg Val Pro Pro Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Lys Lys Asn Glu Val Phe Ile Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Val Asn Ala Asn Gly Ser Val Leu Leu Ser 
            180                 185                 190         


Glu Ile Val Gly Thr Ile Lys Leu Lys Val Phe Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Leu Arg Leu Gly Leu Asn Asp Arg Val Leu Phe Glu Leu Thr Gly 
    210                 215                 220                 


Arg Ser Lys Asn Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln 
225                 230                 235                 240 


Cys Val Arg Leu Ser Arg Phe Asp Asn Asp Arg Thr Ile Ser Phe Ile 
                245                 250                 255     


Pro Pro Asp Gly Asp Phe Glu Leu Met Ser Tyr Arg Leu Ser Thr Gln 
            260                 265                 270         


Val Lys Pro Leu Ile Trp Ile Glu Ser Val Ile Glu Lys Phe Ser His 
        275                 280                 285             


Ser Arg Val Glu Ile Met Val Lys Ala Lys Gly Gln Phe Lys Lys Gln 
    290                 295                 300                 


Ser Val Ala Asn Gly Val Glu Ile Ser Val Pro Val Pro Ser Asp Ala 
305                 310                 315                 320 


Asp Ser Pro Arg Phe Lys Thr Ser Val Gly Ser Ala Lys Tyr Val Pro 
                325                 330                 335     


Glu Arg Asn Val Val Ile Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys 
            340                 345                 350         


Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Lys Glu 
        355                 360                 365             


Glu Val Glu Gly Arg Pro Pro Ile Gly Val Lys Phe Glu Ile Pro Tyr 
    370                 375                 380                 


Phe Thr Val Ser Gly Ile Gln Val Arg Tyr Met Lys Ile Ile Glu Lys 
385                 390                 395                 400 


Ser Gly Tyr Gln Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Ser Gly 
                405                 410                 415     


Asp Tyr Gln Leu Arg Thr Ser 
            420             


<210>  7997
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-Jun__Homo_sapiens__AAD25870

<400>  7997
auguccgccu cggcugucuu cauucuggac guuaagggca agccauugau cagccgcaac       60

uacaagggcg auguggccau gagcaagauu gagcacuuca ugccuuugcu gguacagcgg      120

gaggaggaag gcgcccuggc cccgcugcug agccacggcc agguccacuu ccuauggauc      180

aaacacagca accucuacuu gguggccacc acaucgaaga augccaaugc cucccuggug      240

uacuccuucc uguauaagac aauagaggua uucugcgaau acuucaagga gcuggaggag      300

gagagcaucc gggacaacuu ugucaucguc uacgaguugc uggacgagcu cauggacuuu      360

ggcuucccgc agaccaccga cagcaagauc cugcaggagu acaucacuca gcagagcaac      420

aagcuggaga cgggcaaguc acgggugcca cccacuguca ccaacgcugu guccuggcgc      480

uccgagggua ucaaguauaa gaagaacgag gucuucauug augucauaga gucugucaac      540

cugcugguca augccaacgg cagcguccuu cugagcgaaa ucgucgguac caucaagcuc      600

aagguguuuc ugucaggaau gccagagcug cggcugggcc ucaaugaccg cgugcucuuc      660

gagcucacug gccgcagcaa gaacaaauca guagagcugg aggauguaaa auuccaccag      720

ugcgugcggc ucucucgcuu ugacaacgac cgcaccaucu ccuucauccc gccugauggu      780

gacuuugagc ucaugucaua ccgccucagc acccagguca agccacugau cuggauugag      840

ucugucauug agaaguucuc ccacagccgc guggagauca uggucaaggc caaggggcag      900

uuuaagaaac agucaguggc caacggugug gagauaucug ugccuguacc cagcgaugcc      960

gacuccccca gauucaagac cagugugggc agcgccaagu augugccgga gagaaacguc     1020

gugauuugga guauuaaguc uuucccgggg ggcaaggagu acuugaugcg agcccacuuu     1080

ggccucccca guguggaaaa ggaagaggug gagggccggc cccccaucgg ggucaaguuu     1140

gagauccccu acuucaccgu cucugggauc cagguccgau acaugaagau cauugagaaa     1200

agugguuacc aggcccugcc cuggguucgc uacaucaccc agaguggcga uuaccaacuu     1260

cguaccagcu ag                                                         1272


<210>  7998
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-Jun__Homo_sapiens__AAD25870

<400>  7998
augagcgccu ccgccguguu cauccuggac gucaagggca agccccucau cagccgcaac       60

uacaaggggg acguggcgau guccaagauc gagcacuuca ugccgcugcu ggugcagcgg      120

gaggaggagg gcgcccucgc gccccugcug agccacgggc agguccacuu ccucuggauc      180

aagcacucca accuguaccu gguggccacc accagcaaga acgccaacgc cucccucgug      240

uacagcuucc uguacaagac gaucgagguc uucugcgagu acuucaagga gcuggaggag      300

gaguccaucc gcgacaacuu cgugaucgug uacgagcucc uggacgagcu gauggacuuc      360

ggcuuccccc agaccaccga cagcaagauc cuccaggagu acaucaccca gcaguccaac      420

aagcuggaga cgggcaagag ccgggugccc ccgaccguca ccaacgccgu guccuggcgc      480

agcgagggga ucaaguacaa gaagaacgag gucuucaucg acgugaucga guccgugaac      540

cugcucguca acgccaacgg cagcgugcug cuguccgaga ucguggggac caucaagcuc      600

aaggucuucc ugagcggcau gcccgagcug cggcucgggc ugaacgaccg cgugcuguuc      660

gagcucacgg gccgguccaa gaacaagagc guggagcugg aggacgucaa guuccaccag      720

ugcgugcgcc ugagccgguu cgacaacgac cgcaccaucu ccuucauccc gcccgacggg      780

gacuucgagc ucaugagcua ccggcugucc acccagguga agccccugau cuggaucgag      840

agcgucaucg agaaguucuc ccacagccgc guggagauca uggucaaggc caagggccag      900

uucaagaagc aguccguggc gaacggcgug gagaucagcg uccccgugcc cuccgacgcc      960

gacagccccc gguucaagac cuccgugggg agcgccaagu acgucccgga gcgcaacgug     1020

gugaucuggu ccaucaagag cuuccccggc gggaaggagu accucaugcg ggcccacuuc     1080

ggccugcccu ccgucgagaa ggaggaggug gagggccggc ccccgaucgg ggugaaguuc     1140

gagauccccu acuucacggu cagcggcauc caggugcgcu acaugaagau caucgagaag     1200

uccggguacc aggcccugcc cugggugcgc uacaucaccc agagcggcga cuaccagcuc     1260

cggaccuccu ga                                                         1272


<210>  7999
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-Jun__Homo_sapiens__AAD25870

<400>  7999
auguccgccu ccgccgucuu cauccucgac gucaagggca agccccucau cucccgcaac       60

uacaagggcg acgucgccau guccaagauc gagcacuuca ugccccuccu cguccagcgc      120

gaggaggagg gcgcccucgc cccccuccuc ucccacggcc agguccacuu ccucuggauc      180

aagcacucca accucuaccu cgucgccacc accuccaaga acgccaacgc cucccucguc      240

uacuccuucc ucuacaagac caucgagguc uucugcgagu acuucaagga gcucgaggag      300

gaguccaucc gcgacaacuu cgucaucguc uacgagcucc ucgacgagcu cauggacuuc      360

ggcuuccccc agaccaccga cuccaagauc cuccaggagu acaucaccca gcaguccaac      420

aagcucgaga ccggcaaguc ccgcgucccc cccaccguca ccaacgccgu cuccuggcgc      480

uccgagggca ucaaguacaa gaagaacgag gucuucaucg acgucaucga guccgucaac      540

cuccucguca acgccaacgg cuccguccuc cucuccgaga ucgucggcac caucaagcuc      600

aaggucuucc ucuccggcau gcccgagcuc cgccucggcc ucaacgaccg cguccucuuc      660

gagcucaccg gccgcuccaa gaacaagucc gucgagcucg aggacgucaa guuccaccag      720

ugcguccgcc ucucccgcuu cgacaacgac cgcaccaucu ccuucauccc ccccgacggc      780

gacuucgagc ucauguccua ccgccucucc acccagguca agccccucau cuggaucgag      840

uccgucaucg agaaguucuc ccacucccgc gucgagauca uggucaaggc caagggccag      900

uucaagaagc aguccgucgc caacggcguc gagaucuccg uccccguccc cuccgacgcc      960

gacucccccc gcuucaagac cuccgucggc uccgccaagu acguccccga gcgcaacguc     1020

gucaucuggu ccaucaaguc cuuccccggc ggcaaggagu accucaugcg cgcccacuuc     1080

ggccuccccu ccgucgagaa ggaggagguc gagggccgcc cccccaucgg cgucaaguuc     1140

gagauccccu acuucaccgu cuccggcauc cagguccgcu acaugaagau caucgagaag     1200

uccggcuacc aggcccuccc cuggguccgc uacaucaccc aguccggcga cuaccagcuc     1260

cgcaccuccu ga                                                         1272


<210>  8000
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-Jun__Homo_sapiens__AAD25870

<400>  8000
augagcgccu ccgcuguguu cauccuggac gucaagggca aaccccucau uucuagaaac       60

uacaaggggg auguugcaau gucaaaaaua gagcacuuua ugccucuucu ggugcagagg      120

gaagaggaag gagccuuggc gccauuacug agucaugguc aaguacacuu ccuauggauc      180

aagcauagca aucucuaucu gguggcuacc acauccaaaa acgccaaugc aucucuuguc      240

uacucguuuc uguauaagac uauugaggug uucugcgaau acuuuaagga guuggaggaa      300

gagucaaucc gggacaacuu cguuauugug uaugaacucc uggaugagcu gauggacuuu      360

ggcuucccgc agacgaccga uagcaaaauc cuccaggagu acauaacaca gcaaaguaau      420

aaguuagaaa cugggaaauc ccgcgugccc ccuaccguca caaacgccgu aucuuggcga      480

agcgagggaa ucaaguauaa aaagaaugaa guuuuuauug acgugaucga guccgucaac      540

cugcuuguga augcuaacgg cucaguguug cugagugaaa uugucgguac caucaagcua      600

aaaguuuucc ucagcgggau gccagagcug cgucuuggac ugaaugauag aguguuguuu      660

gagcucacug gcaggucuaa gaacaaaucc guagaacugg aggacgugaa guuccaccag      720

uguguccggu uaucacgcuu ugauaaugac agaacaauua gcuucauacc cccugauggc      780

gacuucgaac ugaugaguua caggcucucu acccagguga aaccacuuau cuggauugag      840

uccguuaucg aaaaguuuag ccauucgcgg guggagauca uggucaaagc aaaggggcag      900

uucaagaaac aaucuguggc caacggagua gagauuuccg uucccgugcc uucagaugcu      960

gacaguccac gcuuuaagac gagcgucggu uccgccaaau acgugccgga acgaaauguc     1020

gugauauggu cuaucaagag cuuccccggc gggaaagagu aucugaugag agcgcacuuu     1080

ggauugccuu caguugaaaa ggaggaagug gagggcaggc cacccauugg uguaaaguuc     1140

gagaucccuu acuuuacugu cagugggaua caggugcggu auaugaaaau uaucgaaaag     1200

uccggauacc aggcacuacc auggguucgu uauaucaccc agagcggcga cuaccaacug     1260

cgcacaucuu ga                                                         1272


<210>  8001
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-Jun__Homo_sapiens__AAD25870

<400>  8001
augagcgcca gcgccguguu cauccuggac gugaagggca agccccugau cagcagaaac       60

uacaagggcg acguggccau gagcaagauc gagcacuuca ugccccugcu ggugcagaga      120

gaggaggagg gcgcccuggc cccccugcug agccacggcc aggugcacuu ccuguggauc      180

aagcacagca accuguaccu gguggccacc accagcaaga acgccaacgc cagccuggug      240

uacagcuucc uguacaagac caucgaggug uucugcgagu acuucaagga gcuggaggag      300

gagagcauca gagacaacuu cgugaucgug uacgagcugc uggacgagcu gauggacuuc      360

ggcuuccccc agaccaccga cagcaagauc cugcaggagu acaucaccca gcagagcaac      420

aagcuggaga ccggcaagag cagagugccc cccaccguga ccaacgccgu gagcuggaga      480

agcgagggca ucaaguacaa gaagaacgag guguucaucg acgugaucga gagcgugaac      540

cugcugguga acgccaacgg cagcgugcug cugagcgaga ucgugggcac caucaagcug      600

aagguguucc ugagcggcau gcccgagcug agacugggcc ugaacgacag agugcuguuc      660

gagcugaccg gcagaagcaa gaacaagagc guggagcugg aggacgugaa guuccaccag      720

ugcgugagac ugagcagauu cgacaacgac agaaccauca gcuucauccc ccccgacggc      780

gacuucgagc ugaugagcua cagacugagc acccagguga agccccugau cuggaucgag      840

agcgugaucg agaaguucag ccacagcaga guggagauca uggugaaggc caagggccag      900

uucaagaagc agagcguggc caacggcgug gagaucagcg ugcccgugcc cagcgacgcc      960

gacagcccca gauucaagac cagcgugggc agcgccaagu acgugcccga gagaaacgug     1020

gugaucugga gcaucaagag cuuccccggc ggcaaggagu accugaugag agcccacuuc     1080

ggccugccca gcguggagaa ggaggaggug gagggcagac cccccaucgg cgugaaguuc     1140

gagauccccu acuucaccgu gagcggcauc caggugagau acaugaagau caucgagaag     1200

agcggcuacc aggcccugcc cugggugaga uacaucaccc agagcggcga cuaccagcug     1260

agaaccagcu ga                                                         1272


<210>  8002
<211>  1272
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-Jun__Homo_sapiens__AAD25870

<400>  8002
augagcgcuu ccgcuguguu cauccuggac gucaagggca aaccccucau uucuagaaac       60

uacaaggggg auguugccau gagcaaaauc gagcacuuua ugccucugcu ugugcagcgg      120

gaagaggaag gagcgcuggc uccgcuccug ucccauggcc aagugcacuu ccuuuggauu      180

aagcauucua aucuguaucu cgucgccacc acaagcaaaa acgccaaugc uucccuggug      240

uacucuuuuc uguauaagac gaucgagguu uucugcgaau acuuuaagga gcucgaggaa      300

gagagcauuc gcgacaacuu cgugaucguc uaugaacugc uugaugagcu gauggacuuu      360

ggguuccccc agaccacaga uuccaaaauc cuccaggagu acauuaccca gcaaagcaau      420

aagcuggaaa caggaaaauc uagagugccu cccaccguua caaacgccgu guccuggcgg      480

agcgagggca ucaaguauaa aaagaaugaa gucuuuauug acgugaucga gucugugaac      540

cuucugguca augcuaacgg guccguucuc cugagcgaaa uugugggaac caucaagcug      600

aaaguguucc ucucuggcau gccugagcug cgccuuggcc ugaaugauag aguccucuuu      660

gagcugacgg ggcgguccaa gaacaaaagc guggaacuug aggacguuaa guuccaccag      720

ugugugcgcc uguccagauu ugauaaugac cggaccauuu cuuucauucc cccugaugga      780

gacuucgaac ucaugagcua ccgccugucc acacagguca aaccgcugau cuggaucgag      840

agcgugaucg aaaaguuuuc ucauuccaga guugagauua uggugaaagc caagggccag      900

uucaagaaac aaagcgucgc gaacggggug gagaucucug uccccgugcc uagcgaugcc      960

gacucucccc gguuuaagac cuccguugga agcgcuaaau acgugccuga acgcaauguc     1020

gugauuuggu ccaucaagag cuuccccggc gggaaagagu aucucaugag agcccacuuu     1080

ggacugccgu cuguugaaaa ggaggaagug gagggccggc cucccaucgg cgucaaguuc     1140

gagauuccuu acuuuacagu guccgggauc caggugcgcu auaugaaaau uaucgaaaag     1200

agcggauacc aggcccuucc cuggguuaga uauauuaccc agucuggcga cuaccaacug     1260

cggacguccu ga                                                         1272


<210>  8003
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CO8A__Homo_sapiens__P07357

<400>  8003

Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro 
1               5                   10                  15      


Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala 
            20                  25                  30          


Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr 
        35                  40                  45              


Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu 
    50                  55                  60                  


Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp 
65                  70                  75                  80  


Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys 
                85                  90                  95      


Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His 
            100                 105                 110         


Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp 
        115                 120                 125             


Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu 
    130                 135                 140                 


Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr 
145                 150                 155                 160 


Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln 
                165                 170                 175     


Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser 
            180                 185                 190         


Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly 
    210                 215                 220                 


Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val 
225                 230                 235                 240 


Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro 
                245                 250                 255     


Ala Gly Ser Pro Leu Leu Val Gly Val Gly Val Ser His Ser Gln Asp 
            260                 265                 270         


Thr Ser Phe Leu Asn Glu Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile 
        275                 280                 285             


Phe Thr Arg Ile Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg 
    290                 295                 300                 


Lys Asp Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu 
305                 310                 315                 320 


Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp 
                325                 330                 335     


Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile Tyr Glu 
            340                 345                 350         


Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser Leu Gly Ile Thr 
        355                 360                 365             


Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly Ser Leu Gly Ile Gln Tyr 
    370                 375                 380                 


Glu Asp Lys Ile Asn Val Gly Gly Gly Leu Ser Gly Asp His Cys Lys 
385                 390                 395                 400 


Lys Phe Gly Gly Gly Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val 
                405                 410                 415     


Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly 
            420                 425                 430         


Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg 
        435                 440                 445             


Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile 
    450                 455                 460                 


His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala Lys Arg 
465                 470                 475                 480 


Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu Met Glu Phe Asn Ala 
                485                 490                 495     


Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val Pro Ile Leu Glu Gly 
            500                 505                 510         


Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser Leu Gly Ala Ala Cys 
        515                 520                 525             


Glu Gln Thr Gln Thr Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys 
    530                 535                 540                 


Trp Ser Ser Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg 
545                 550                 555                 560 


Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly 
                565                 570                 575     


Arg Lys Val Gln Thr Gln Ala Cys 
            580                 


<210>  8004
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CO8A__Homo_sapiens__AAA52200

<400>  8004
auguuugcug uuguuuucuu caucuugucu uugaugacuu gucagccugg gguaacugca       60

caggagaagg ugaaccagag aguaagacgg gcagcuacac ccgcagcagu uaccugccag      120

cugagcaacu ggucagagug gacagauugc uuuccgugcc aggacaaaaa guaccgacac      180

cggagccucu ugcagccaaa caaguuuggg ggaaccaucu gcagugguga caucugggau      240

caagccagcu gcuccaguuc uacaacuugu guaaggcaag cacagugugg acaggauuuc      300

caguguaagg agacaggucg cugccugaaa cgccaccuug uguguaaugg agaccaggac      360

ugccuugaug gcucugauga ggacgacugu gaagauguca gggccauuga cgaagacugc      420

agccaguaug aaccaauucc aggaucacag aaggcagccu ugggguacaa uauccugacc      480

caggaagaug cucagagugu guacgaugcc aguuauuaug ggggccagug ugagacggua      540

uacaaugggg aauggaggga gcuucgauau gacuccaccu gugaacgucu cuacuaugga      600

gaugaugaga aauacuuucg gaaacccuac aacuuucuga aguaccacuu ugaagcccug      660

gcagauacug gaaucuccuc agaguuuuau gauaaugcaa augaccuucu uuccaaaguu      720

aaaaaagaca agucugacuc auuuggagug accaucggca uaggcccagc cggcagcccu      780

uuauuggugg guguaggugu aucccacuca caagacacuu cauucuugaa cgaauuaaac      840

aaguauaaug agaagaaauu cauuuucaca agaaucuuca caaaggugca gacugcacau      900

uuuaagauga ggaaggauga cauuaugcug gaugaaggaa ugcugcaguc auuaauggag      960

cuuccagauc aguacaauua uggcauguau gccaaguuca ucaaugacua uggcacccau     1020

uacaucacau cuggauccau ggguggcauu uaugaauaua uccuggugau ugacaaagca     1080

aaaauggaau cccuugguau uaccagcaga gauaucacga cauguuuugg aggcuccuug     1140

ggcauucaau augaagacaa aauaaauguu gguggagguu uaucaggaga ccauuguaaa     1200

aaauuuggag guggcaaaac ugaaagggcc aggaaggcca uggcugugga agacauuauu     1260

ucucgggugc gagguggcag uucuggcugg agcgguggcu uggcacagaa caggagcacc     1320

auuacauacc guuccugggg gaggucauua aaguauaauc cuguuguuau cgauuuugag     1380

augcagccua uccacgaggu gcugcggcac acaagccugg ggccucugga ggccaagcgc     1440

cagaaccugc gccgcgccuu ggaccaguau cugauggaau ucaaugccug ccgauguggg     1500

ccuugcuuca acaauggggu gcccauccuc gagggcacca gcugcaggug ccagugccgc     1560

cuggguagcu ugggugcugc cugugagcaa acacagacag aaggagccaa agcagauggg     1620

agcuggaguu gcuggagcuc cuggucugua ugcagagcag gcauccagga aaggagaaga     1680

gagugugaca auccagcacc ucagaaugga ggggccucgu guccagggcg gaaaguacag     1740

acgcaggcuu gcuga                                                      1755


<210>  8005
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CO8A__Homo_sapiens__AAA52200

<400>  8005
auguucgccg uggucuucuu cauccugagc cucaugaccu gccagcccgg cgugaccgcc       60

caggagaagg ugaaccagcg cguccggcgc gccgccacgc cggccgccgu gaccugccag      120

cuguccaacu ggagcgagug gaccgacugc uuccccugcc aggacaagaa guaccggcac      180

cgcucccugc uccagcccaa caaguucggg ggcaccaucu gcagcgggga caucugggac      240

caggccuccu gcagcuccag cacgaccugc gugcggcagg cgcagugcgg ccaggacuuc      300

cagugcaagg agaccgggcg cugccugaag cggcaccugg ucugcaacgg cgaccaggac      360

ugccucgacg gcuccgacga ggacgacugc gaggacgugc gcgccaucga cgaggacugc      420

agccaguacg agcccauccc ggggucccag aaggccgccc ugggcuacaa cauccugacc      480

caggaggacg cgcagagcgu guacgacgcc uccuacuacg ggggccagug cgagacgguc      540

uacaacgggg aguggcggga gcuccgcuac gacagcacgu gcgagcggcu guacuacggc      600

gacgacgaga aguacuuccg caagcccuac aacuuccuga aguaccacuu cgaggcccuc      660

gccgacaccg gcaucuccag cgaguucuac gacaacgcca acgaccugcu guccaaggug      720

aagaaggaca agagcgacuc cuucggggug accaucggca ucgggcccgc gggcagcccc      780

cuccuggucg gcgugggggu gagccacucc caggacacca gcuuccugaa cgagcucaac      840

aaguacaacg agaagaaguu caucuucacc cggaucuuca ccaaggucca gaccgcccac      900

uucaagaugc gcaaggacga caucaugcug gacgagggca ugcugcaguc ccucauggag      960

cugccggacc aguacaacua cgggauguac gccaaguuca ucaacgacua cggcacgcac     1020

uacaucacca gcggguccau gggcggcauc uacgaguaca uccuggugau cgacaaggcc     1080

aagauggaga gccucgggau caccucccgg gacaucacca cgugcuucgg cgggagccug     1140

ggcauccagu acgaggacaa gaucaacguc gggggcggcc uguccgggga ccacugcaag     1200

aaguucggcg ggggcaagac cgagcgcgcc cggaaggcga uggccgugga ggacaucauc     1260

agccgcgugc gcgggggcuc cagcggcugg uccgggggcc ucgcccagaa ccggagcacc     1320

aucaccuacc gguccugggg gcgcagccug aaguacaacc ccguggucau cgacuucgag     1380

augcagccca uccacgaggu gcugcgccac acgucccucg gcccccugga ggccaagcgg     1440

cagaaccugc gccgggcccu cgaccaguac cugauggagu ucaacgcgug ccgcugcggc     1500

ccgugcuuca acaacggggu gcccauccug gagggcacca gcugccggug ccagugccgc     1560

cucggguccc ugggcgccgc cugcgagcag acccagaccg agggggccaa ggccgacggc     1620

agcuggagcu gcugguccag cugguccguc ugccgggcgg gcauccagga gcgccggcgc     1680

gagugcgaca accccgcgcc ccagaacggg ggcgccagcu gcccggggcg gaaggugcag     1740

acgcaggccu gcuga                                                      1755


<210>  8006
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CO8A__Homo_sapiens__AAA52200

<400>  8006
auguucgccg ucgucuucuu cauccucucc cucaugaccu gccagcccgg cgucaccgcc       60

caggagaagg ucaaccagcg cguccgccgc gccgccaccc ccgccgccgu caccugccag      120

cucuccaacu gguccgagug gaccgacugc uuccccugcc aggacaagaa guaccgccac      180

cgcucccucc uccagcccaa caaguucggc ggcaccaucu gcuccggcga caucugggac      240

caggccuccu gcuccuccuc caccaccugc guccgccagg cccagugcgg ccaggacuuc      300

cagugcaagg agaccggccg cugccucaag cgccaccucg ucugcaacgg cgaccaggac      360

ugccucgacg gcuccgacga ggacgacugc gaggacgucc gcgccaucga cgaggacugc      420

ucccaguacg agcccauccc cggcucccag aaggccgccc ucggcuacaa cauccucacc      480

caggaggacg cccaguccgu cuacgacgcc uccuacuacg gcggccagug cgagaccguc      540

uacaacggcg aguggcgcga gcuccgcuac gacuccaccu gcgagcgccu cuacuacggc      600

gacgacgaga aguacuuccg caagcccuac aacuuccuca aguaccacuu cgaggcccuc      660

gccgacaccg gcaucuccuc cgaguucuac gacaacgcca acgaccuccu cuccaagguc      720

aagaaggaca aguccgacuc cuucggcguc accaucggca ucggccccgc cggcuccccc      780

cuccucgucg gcgucggcgu cucccacucc caggacaccu ccuuccucaa cgagcucaac      840

aaguacaacg agaagaaguu caucuucacc cgcaucuuca ccaaggucca gaccgcccac      900

uucaagaugc gcaaggacga caucaugcuc gacgagggca ugcuccaguc ccucauggag      960

cuccccgacc aguacaacua cggcauguac gccaaguuca ucaacgacua cggcacccac     1020

uacaucaccu ccggcuccau gggcggcauc uacgaguaca uccucgucau cgacaaggcc     1080

aagauggagu cccucggcau caccucccgc gacaucacca ccugcuucgg cggcucccuc     1140

ggcauccagu acgaggacaa gaucaacguc ggcggcggcc ucuccggcga ccacugcaag     1200

aaguucggcg gcggcaagac cgagcgcgcc cgcaaggcca uggccgucga ggacaucauc     1260

ucccgcgucc gcggcggcuc cuccggcugg uccggcggcc ucgcccagaa ccgcuccacc     1320

aucaccuacc gcuccugggg ccgcucccuc aaguacaacc ccgucgucau cgacuucgag     1380

augcagccca uccacgaggu ccuccgccac accucccucg gcccccucga ggccaagcgc     1440

cagaaccucc gccgcgcccu cgaccaguac cucauggagu ucaacgccug ccgcugcggc     1500

cccugcuuca acaacggcgu ccccauccuc gagggcaccu ccugccgcug ccagugccgc     1560

cucggcuccc ucggcgccgc cugcgagcag acccagaccg agggcgccaa ggccgacggc     1620

uccugguccu gcugguccuc cugguccguc ugccgcgccg gcauccagga gcgccgccgc     1680

gagugcgaca accccgcccc ccagaacggc ggcgccuccu gccccggccg caagguccag     1740

acccaggccu gcuga                                                      1755


<210>  8007
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CO8A__Homo_sapiens__AAA52200

<400>  8007
auguucgccg uggucuuuuu cauccugagc cucaugaccu gccagcccgg cguuacagcu       60

caagagaagg ugaaccagag aguaaggcgg gcagccacuc cugcggcugu gacgugucag      120

cuuuccaauu ggucugaaug gaccgacugc uuuccauguc aggauaaaaa guaccgccac      180

cgaucacugu ugcaaccgaa caaauucggg ggaacaauuu gcagugguga cauaugggau      240

caggccagcu guuccucuuc gacuaccugc guccgucagg cacagugugg ccaagacuuu      300

cagugcaagg agacagggag auguuuaaaa aggcaucugg ugugcaaugg agaucaggac      360

ugucuagaug gcucagacga agaugacugc gaggauguuc gggccaucga cgaagauugc      420

agccaguaug agcccauucc ugguagucaa aaggcugcac ucggguacaa cauccugacc      480

caggaggacg cccaguccgu guaugacgcu ucuuacuaug gaggccaaug ugaaacuguc      540

uacaauggcg aguggcgcga acuuagauau gauagcacau gcgagaggcu guacuacggg      600

gacgaugaga aguauuuccg gaaaccauac aacuuuuuga aguaucacuu cgaagcccuc      660

gcggacaccg gaauuuccuc agaguuuuac gauaaugcaa acgaccugcu gaguaaagug      720

aagaaagaua agagcgacuc uuucggugua acgaucggca uagggcccgc cggauccccu      780

cucuuaguug gcgugggugu cucacauagc caggauacca guuuucugaa ugaacuuaac      840

aaguauaaug agaaaaaguu caucuuuacu cgcauuuuca caaaagugca gacugcucac      900

uucaagaugc gaaaagacga uaucauguug gacgaaggga ugcugcaguc ucuaauggag      960

cucccagacc aauacaacua uggaauguac gccaaguuua uuaaugauua cggcacccau     1020

uauaucacau ccggcagcau gggagggaua uacgaguaua uucuggugau cgacaaagca     1080

aagauggaau cgcuugguau uaccucuaga gauaucacga cuuguuucgg cgggucccug     1140

ggaauccagu acgaggacaa gauuaacguc ggcggugggu ugucaggcga ucacugcaaa     1200

aaguuuggag gcgggaaaac agaaagggcu cggaaggcca uggcgguuga ggacauaauc     1260

agucgugugc gcggagguag cuccggcugg ucugggggac ucgcccagaa uagaagcacc     1320

auuacuuaua ggucaugggg ccggagucug aaauacaacc ccguagugau cgauuucgaa     1380

augcagccua uacacgaggu cuuacgacau acaucccugg guccacucga ggcaaagcgc     1440

caaaaccuua gaagggcucu ggaccaguau uugauggaau uuaaugccug ucggugcggg     1500

ccguguuuca acaauggcgu gcccauucua gagggaacca gcugccgcug ucagugcaga     1560

cugggcucuc ucggggcugc cugugaacag acgcaaaccg agggagcaaa ggccgauggu     1620

ucauggaguu gcuggagcuc cuggucuguu ugcagggcug gcauccagga acgucggcga     1680

gagugugaca acccugcgcc acagaauggg ggagcaucgu gccccggcag aaaagugcag     1740

acacaagccu guuga                                                      1755


<210>  8008
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CO8A__Homo_sapiens__AAA52200

<400>  8008
auguucgccg ugguguucuu cauccugagc cugaugaccu gccagcccgg cgugaccgcc       60

caggagaagg ugaaccagag agugagaaga gccgccaccc ccgccgccgu gaccugccag      120

cugagcaacu ggagcgagug gaccgacugc uuccccugcc aggacaagaa guacagacac      180

agaagccugc ugcagcccaa caaguucggc ggcaccaucu gcagcggcga caucugggac      240

caggccagcu gcagcagcag caccaccugc gugagacagg cccagugcgg ccaggacuuc      300

cagugcaagg agaccggcag augccugaag agacaccugg ugugcaacgg cgaccaggac      360

ugccuggacg gcagcgacga ggacgacugc gaggacguga gagccaucga cgaggacugc      420

agccaguacg agcccauccc cggcagccag aaggccgccc ugggcuacaa cauccugacc      480

caggaggacg cccagagcgu guacgacgcc agcuacuacg gcggccagug cgagaccgug      540

uacaacggcg aguggagaga gcugagauac gacagcaccu gcgagagacu guacuacggc      600

gacgacgaga aguacuucag aaagcccuac aacuuccuga aguaccacuu cgaggcccug      660

gccgacaccg gcaucagcag cgaguucuac gacaacgcca acgaccugcu gagcaaggug      720

aagaaggaca agagcgacag cuucggcgug accaucggca ucggccccgc cggcagcccc      780

cugcuggugg gcgugggcgu gagccacagc caggacacca gcuuccugaa cgagcugaac      840

aaguacaacg agaagaaguu caucuucacc agaaucuuca ccaaggugca gaccgcccac      900

uucaagauga gaaaggacga caucaugcug gacgagggca ugcugcagag ccugauggag      960

cugcccgacc aguacaacua cggcauguac gccaaguuca ucaacgacua cggcacccac     1020

uacaucacca gcggcagcau gggcggcauc uacgaguaca uccuggugau cgacaaggcc     1080

aagauggaga gccugggcau caccagcaga gacaucacca ccugcuucgg cggcagccug     1140

ggcauccagu acgaggacaa gaucaacgug ggcggcggcc ugagcggcga ccacugcaag     1200

aaguucggcg gcggcaagac cgagagagcc agaaaggcca uggccgugga ggacaucauc     1260

agcagaguga gaggcggcag cagcggcugg agcggcggcc uggcccagaa cagaagcacc     1320

aucaccuaca gaagcugggg cagaagccug aaguacaacc ccguggugau cgacuucgag     1380

augcagccca uccacgaggu gcugagacac accagccugg gcccccugga ggccaagaga     1440

cagaaccuga gaagagcccu ggaccaguac cugauggagu ucaacgccug cagaugcggc     1500

cccugcuuca acaacggcgu gcccauccug gagggcacca gcugcagaug ccagugcaga     1560

cugggcagcc ugggcgccgc cugcgagcag acccagaccg agggcgccaa ggccgacggc     1620

agcuggagcu gcuggagcag cuggagcgug ugcagagccg gcauccagga gagaagaaga     1680

gagugcgaca accccgcccc ccagaacggc ggcgccagcu gccccggcag aaaggugcag     1740

acccaggccu gcuga                                                      1755


<210>  8009
<211>  1755
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CO8A__Homo_sapiens__AAA52200

<400>  8009
auguucgccg uggucuuuuu cauccugagc cucaugaccu gccagcccgg cguuacagcu       60

caagagaagg ugaaccagag agugcggcgc gccgcgacgc cugcugccgu caccugucag      120

cuguccaauu ggucugaaug gacagacugc uuuccguguc aggauaaaaa guacagacac      180

cggagccuuc ugcaacccaa caaauucggg ggaaccauuu gcuccggcga caucugggau      240

caggccucuu guagcuccuc uacaaccugc gugcgccagg cucagugugg gcaagacuuu      300

cagugcaagg agacaggaag augucucaaa cggcaucugg uuugcaaugg cgaucaggac      360

ugucuugaug ggagcgacga agaugacugc gaggaugugc gcgccauuga cgaagauugc      420

ucccaguaug agccuauccc cggaagccaa aaggcugccc ugggcuacaa cauucucacc      480

caggaggacg cgcagucugu cuaugacgcc uccuacuaug gcgggcaaug ugaaacggug      540

uacaauggag aguggagaga acugcgguau gauagcacau gcgagcgccu guacuacggc      600

gacgaugaga aguauuucag aaaaccuuac aacuuucuca aguaucacuu cgaagcucug      660

gccgacacag ggaucucuuc cgaguuuuac gauaaugcua acgaccuucu gagcaaaguu      720

aagaaagaua agucugacuc cuucggagug accaucggca uugggcccgc cggaagcccu      780

cuccuggucg gcgugggcgu gucccauucu caggauacca gcuuucuuaa ugaacugaac      840

aaguauaaug agaaaaaguu caucuuuacc cggauuuuca cgaaagucca gacagcgcac      900

uucaagaugc gcaaagacga uaucaugcuc gacgaaggga ugcugcaguc ccugauggag      960

cucccggacc aauacaacua uggaauguac gccaaguuua uuaaugauua cggcacccau     1020

uauaucacaa gcgggucuau gggaggcauu uacgaguaua uccugguuau cgacaaagcu     1080

aagauggaau cccuugggau uaccagcaga gauaucacca cauguuucgg aggcucucug     1140

ggcauucagu acgaggacaa gaucaacguc gggggaggcc ucagcgggga ucacugcaaa     1200

aaguuuggag gcgggaaaac ggaacgggcc cgcaaggcua uggccgugga ggacauuauc     1260

uccagagugc ggggcggauc uagcggcugg uccgggggac uggcccagaa uagaagcacc     1320

aucacauauc gcucuugggg ccggucccuu aaauacaacc ccgugguuau ugauuucgaa     1380

augcagccua uccacgaggu gcugagacau accagccucg ggccccugga ggcuaagcgc     1440

caaaaccugc ggagagcgcu cgaccaguau cugauggaau uuaaugccug ucgcugcgga     1500

ccuuguuuca acaauggcgu ccccauucuu gaggggacau cuugccggug ucagugcaga     1560

cugggcuccc ucggagcugc cugugaacag acccaaacgg agggcgccaa ggcugauggg     1620

agcugguccu gcuggucuag cugguccgug ugccgcgccg gaauccagga acggagacgc     1680

gagugugaca acccggcgcc ucagaauggc ggggcuucuu gccccggacg gaaaguucag     1740

acacaagccu guuga                                                      1755


<210>  8010
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CO8B__Homo_sapiens__P07358

<400>  8010

Met Lys Asn Ser Arg Thr Trp Ala Trp Arg Ala Pro Val Glu Leu Phe 
1               5                   10                  15      


Leu Leu Cys Ala Ala Leu Gly Cys Leu Ser Leu Pro Gly Ser Arg Gly 
            20                  25                  30          


Glu Arg Pro His Ser Phe Gly Ser Asn Ala Val Asn Lys Ser Phe Ala 
        35                  40                  45              


Lys Ser Arg Gln Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp 
    50                  55                  60                  


Cys Glu Leu Ser Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln 
65                  70                  75                  80  


Lys Lys Arg Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His 
                85                  90                  95      


Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr 
            100                 105                 110         


Asn Arg Pro Cys Arg Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala 
        115                 120                 125             


Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn 
    130                 135                 140                 


Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys 
145                 150                 155                 160 


Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala 
                165                 170                 175     


Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp 
            180                 185                 190         


His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr 
        195                 200                 205             


Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln 
    210                 215                 220                 


Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe 
225                 230                 235                 240 


Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe 
                245                 250                 255     


Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser 
            260                 265                 270         


Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr 
        275                 280                 285             


Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr 
    290                 295                 300                 


Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg 
305                 310                 315                 320 


Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu 
                325                 330                 335     


Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly 
            340                 345                 350         


Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly 
        355                 360                 365             


Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys 
    370                 375                 380                 


Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val 
385                 390                 395                 400 


Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg 
                405                 410                 415     


Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser 
            420                 425                 430         


Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu 
        435                 440                 445             


Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys 
    450                 455                 460                 


Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala 
465                 470                 475                 480 


Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe 
                485                 490                 495     


Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly 
            500                 505                 510         


Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly 
        515                 520                 525             


Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile 
    530                 535                 540                 


Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg 
545                 550                 555                 560 


Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly 
                565                 570                 575     


Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser 
            580                 585                 590     


<210>  8011
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CO8B__Homo_sapiens__AAI30576

<400>  8011
augaagaauu ccaggacaug ggcuuggagg gcgccggugg agcuauuucu ucucugugcu       60

gcccugggcu gucucaguuu gccuggcucc agaggugaaa ggccacauuc cuuuggguca      120

aaugcaguca acaagagcuu ugcuaagagc agacagaugc ggagugugga uguuacccug      180

augcccauug auugugagcu gucuaguugg uccucuugga ccacauguga ccccugucag      240

aagaaaaggu acagguaugc cuacuugcuc cagcccucuc aguuccaugg ggaaccgugc      300

aacuucucug acaaggaagu cgaagacugu guuaccaaca gaccaugcag aagucaagug      360

cgaugugaag gcuuugugug ugcacagaca ggaaggugug uaaaccgcag acuucuuugc      420

aauggggaca augacugugg agaccaguca gaugaagcaa acuguagaag gauuuauaaa      480

aaaugucagc augaaaugga ccaauacugg ggaauuggca gucuggccag ugggauaaau      540

uuguucacaa acaguuuuga gggcccaguu cuugaucaca gguauuaugc agguggaugc      600

uccccgcauu acauccugaa cacgagguuu aggaagcccu acaaugugga aagcuacacg      660

ccacagaccc aaggcaaaua cgaauucaua uuaaaagagu augaaucaua cucagauuuu      720

gaacgcaaug ucacagagaa aauggcaagc aagucugguu ucaguuuugg uuuuaaaaua      780

ccuggaauau uugaacuugg caucaguagu caaagugauc gaggcaaaca cuauauuagg      840

agaaccaaac gauucucuca uacuaaaagc guauuucugc augcacgcuc ugaccuugaa      900

guagcacauu acaagcugaa acccagaagc cucaugcucc auuacgaguu ccuucagaga      960

guuaagcggc ugccccugga guacagcuac ggggaauaca gagaucucuu ccgugauuuu     1020

gggacccacu acaucacaga ggcugugcuu gggggcauuu augaauacac ccucguuaug     1080

aacaaagagg ccauggagag aggagauuau acucuuaaca acguccaugc cugugccaaa     1140

aaugauuuua aaauuggugg ugccauugaa gaggucuacg ucagucuggg ugugucugua     1200

ggcaaaugca gagguauucu gaaugaaaua aaagacagaa acaagaggga caccauggug     1260

gaggacuugg ugguccuggu acgaggaggg gcaagugagc acaucaccac ccuggcauac     1320

caggagcugc cgacggcgga ccugaugcag gaguggggag acgcugugca guacaaccca     1380

gccaucauca aaguuaaggu ggagccucug uaugaacuag ugacagccac agauuuugcc     1440

uauuccagca cagugaggca gaacaugaag caggcacugg aggaguucca gaaggaaguu     1500

aguuccugcc acugugcucc cugccaagga aauggagucc cuguccugaa aggaucacgc     1560

ugugacugca ucuguccugu uggaucccaa ggccuagccu gugaggucuc cuaucggaag     1620

aauaccccca uugaugggaa guggaauugc uggucaaauu ggucuucaug cucuggaaga     1680

cguaagacaa gacaaaggca guguaacaau ccaccuccuc aaaauggggg uagccccugu     1740

ucaggcccug cuucagaaac acuugacugc uccuag                               1776


<210>  8012
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CO8B__Homo_sapiens__AAI30576

<400>  8012
augaagaaca gccgcaccug ggccuggcgg gcccccgugg agcuguuccu ccugugcgcg       60

gcccugggcu gccucucccu gcccgggagc cgcggcgagc ggccccacuc cuucgggagc      120

aacgccguca acaaguccuu cgccaagagc cgccagaugc gguccgugga cgugacccug      180

augcccaucg acugcgagcu cagcuccugg agcuccugga cgaccugcga ccccugccag      240

aagaagcgcu accgguacgc cuaccugcug cagccgagcc aguuccacgg cgagcccugc      300

aacuucuccg acaaggaggu cgaggacugc gugaccaacc gccccugccg gagccaggug      360

cgcugcgagg gguucgucug cgcgcagacc ggccggugcg ugaaccgccg gcuccugugc      420

aacggcgaca acgacugcgg ggaccagucc gacgaggcca acugccgccg gaucuacaag      480

aagugccagc acgagaugga ccaguacugg ggcaucggga gccuggccuc cggcaucaac      540

cucuucacga acagcuucga ggggcccgug cuggaccacc gcuacuacgc cggcggcugc      600

uccccgcacu acauccugaa cacccgguuc cgcaagcccu acaacgucga gagcuacacg      660

ccccagaccc aggggaagua cgaguucauc cucaaggagu acgagagcua cuccgacuuc      720

gagcggaacg ugaccgagaa gauggcgagc aaguccggcu ucagcuucgg guucaagauc      780

cccggcaucu ucgagcuggg caucuccagc caguccgacc gcgggaagca cuacauccgg      840

cgcaccaagc gcuucagcca caccaagucc guguuccugc acgcccggag cgaccucgag      900

gucgcccacu acaagcugaa gccgcgcucc cugaugcucc acuacgaguu ccugcagcgg      960

gugaagcgcc ugccccucga guacagcuac ggcgaguacc gggaccuguu ccgcgacuuc     1020

gggacccacu acaucacgga ggccgugcug ggcgggaucu acgaguacac ccucgucaug     1080

aacaaggagg ccauggagcg gggcgacuac acccugaaca acgugcacgc gugcgccaag     1140

aacgacuuca agaucggcgg ggccaucgag gagguguacg ucucccuggg cgugagcgug     1200

gggaagugcc gcggcauccu caacgagauc aaggaccgga acaagcgcga caccaugguc     1260

gaggaccugg uggugcuggu ccgcgggggc gccuccgagc acaucacgac ccucgccuac     1320

caggagcugc ccaccgcgga ccugaugcag gaguggggcg acgccgugca guacaacccc     1380

gccaucauca aggucaaggu ggagccgcuc uacgagcugg ugaccgccac ggacuucgcc     1440

uacagcucca ccguccggca gaacaugaag caggcgcugg aggaguucca gaaggaggug     1500

agcuccugcc acugcgcccc cugccagggg aacggcgugc ccguccucaa ggggagccgg     1560

ugcgacugca ucugccccgu gggcagccag gggcuggccu gcgagguguc cuaccgcaag     1620

aacaccccga ucgacggcaa guggaacugc uggagcaacu gguccagcug cuccggccgg     1680

cgcaagaccc ggcagcgcca gugcaacaac ccgccgcccc agaacggggg cagccccugc     1740

uccgggcccg ccagcgagac gcuggacugc uccuga                               1776


<210>  8013
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CO8B__Homo_sapiens__AAI30576

<400>  8013
augaagaacu cccgcaccug ggccuggcgc gcccccgucg agcucuuccu ccucugcgcc       60

gcccucggcu gccucucccu ccccggcucc cgcggcgagc gcccccacuc cuucggcucc      120

aacgccguca acaaguccuu cgccaagucc cgccagaugc gcuccgucga cgucacccuc      180

augcccaucg acugcgagcu cuccuccugg uccuccugga ccaccugcga ccccugccag      240

aagaagcgcu accgcuacgc cuaccuccuc cagcccuccc aguuccacgg cgagcccugc      300

aacuucuccg acaaggaggu cgaggacugc gucaccaacc gccccugccg cucccagguc      360

cgcugcgagg gcuucgucug cgcccagacc ggccgcugcg ucaaccgccg ccuccucugc      420

aacggcgaca acgacugcgg cgaccagucc gacgaggcca acugccgccg caucuacaag      480

aagugccagc acgagaugga ccaguacugg ggcaucggcu cccucgccuc cggcaucaac      540

cucuucacca acuccuucga gggccccguc cucgaccacc gcuacuacgc cggcggcugc      600

uccccccacu acauccucaa cacccgcuuc cgcaagcccu acaacgucga guccuacacc      660

ccccagaccc agggcaagua cgaguucauc cucaaggagu acgaguccua cuccgacuuc      720

gagcgcaacg ucaccgagaa gauggccucc aaguccggcu ucuccuucgg cuucaagauc      780

cccggcaucu ucgagcucgg caucuccucc caguccgacc gcggcaagca cuacauccgc      840

cgcaccaagc gcuucuccca caccaagucc gucuuccucc acgcccgcuc cgaccucgag      900

gucgcccacu acaagcucaa gccccgcucc cucaugcucc acuacgaguu ccuccagcgc      960

gucaagcgcc ucccccucga guacuccuac ggcgaguacc gcgaccucuu ccgcgacuuc     1020

ggcacccacu acaucaccga ggccguccuc ggcggcaucu acgaguacac ccucgucaug     1080

aacaaggagg ccauggagcg cggcgacuac acccucaaca acguccacgc cugcgccaag     1140

aacgacuuca agaucggcgg cgccaucgag gaggucuacg ucucccucgg cgucuccguc     1200

ggcaagugcc gcggcauccu caacgagauc aaggaccgca acaagcgcga caccaugguc     1260

gaggaccucg ucguccucgu ccgcggcggc gccuccgagc acaucaccac ccucgccuac     1320

caggagcucc ccaccgccga ccucaugcag gaguggggcg acgccgucca guacaacccc     1380

gccaucauca aggucaaggu cgagccccuc uacgagcucg ucaccgccac cgacuucgcc     1440

uacuccucca ccguccgcca gaacaugaag caggcccucg aggaguucca gaaggagguc     1500

uccuccugcc acugcgcccc cugccagggc aacggcgucc ccguccucaa gggcucccgc     1560

ugcgacugca ucugccccgu cggcucccag ggccucgccu gcgaggucuc cuaccgcaag     1620

aacaccccca ucgacggcaa guggaacugc ugguccaacu gguccuccug cuccggccgc     1680

cgcaagaccc gccagcgcca gugcaacaac cccccccccc agaacggcgg cucccccugc     1740

uccggccccg ccuccgagac ccucgacugc uccuga                               1776


<210>  8014
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CO8B__Homo_sapiens__AAI30576

<400>  8014
augaagaaca gcagaaccug ggccuggagg gcucccgugg agcuguuccu ccuuugcgca       60

gcccugggcu guuuguccuu accugggucu cggggagaac gcccacacuc auuugguagu      120

aaugcgguca acaagagcuu cgcuaaaucc cgacagaugc guucuguuga cgugacacug      180

augccgaucg auugcgagcu aucgucaugg agcaguugga cuacguguga ccccugccag      240

aaaaagagau acagguaugc cuaccuccug caaccuuccc aguuucaugg cgaaccaugu      300

aauuucucug auaaagaggu agaagacugc gugaccaacc ggcccugucg cagccagguc      360

agaugcgagg gguuugugug ugcacaaaca ggaaggugcg uuaaucggcg ccuucugugu      420

aacggcgaua augacugcgg ugaucagucc gacgaggcca acugccgaag aauuuauaag      480

aagugucagc acgaaaugga ucaguacugg gggauaggau cauuggcuag uggcaucaau      540

cucuucacua acagcuuuga gggcccugug cuggaccaua gguauuacgc agggggaugc      600

ucuccacacu auauucugaa uacccgguuc cguaaacccu acaacgucga auccuacaca      660

ccucaaaccc aggguaagua ugaguuuauc cucaaagagu acgaaucaua uagcgauuuc      720

gagcgcaaug ugacugaaaa gauggccagu aaaucuggcu uuuccuucgg guuuaagauu      780

ccaggaaucu ucgaguuagg cauaagcucg cagucugaca gagguaagca uuacaucagg      840

cggacaaaac gauucuccca caccaaguca guauuucugc acgcucgcag ugaucuugaa      900

guugcccauu auaaauugaa gccgagaagc cugaugcuac acuacgaguu ccuccagagg      960

gugaaacggc ugccccuuga guauuccuac ggggaauacc gcgaccuguu uagagacuuc     1020

ggaacgcauu auauuacuga ggcggucuug ggcggcaucu acgaauauac ccucgugaug     1080

aacaaggagg caauggaacg uggggauuac acacugaaua acgugcacgc cugugcuaaa     1140

aacgacuuua agauuggagg ugccaucgag gaggucuaug uuucuuuagg cgugagcgua     1200

gggaagugca ggggaauacu gaaugaaauu aaagaucgga acaagcgaga cacuauggug     1260

gaggaucucg ucgugcuugu uagaggcggu gcaucagaac acaucaccac acuggcuuac     1320

caagaguugc cuaccgccga ccuaaugcag gaauggggcg augcggugca guauaaucca     1380

gccauuauca aagucaaggu ggagccccug uacgagcucg uaacggcaac ugacuucgcu     1440

uacaguucca caguuaggca aaacaugaaa caggcccugg aagaguuuca gaaggaagug     1500

agcucuuguc auugcgcucc uugucagggg aauggagucc cagugcuuaa gggcucacgc     1560

ugcgauugua ucugccccgu cgggagucaa ggacuggccu gugaggugag cuaucggaaa     1620

aacaccccga uugacgguaa guggaauugc ugguccaacu ggucuucgug cagcggcaga     1680

aggaaaacuc gccagcgaca guguaauaac ccucccccac agaauggggg auccccuugc     1740

ucaggccccg caagugagac auuggauugu ucuuga                               1776


<210>  8015
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CO8B__Homo_sapiens__AAI30576

<400>  8015
augaagaaca gcagaaccug ggccuggaga gcccccgugg agcuguuccu gcugugcgcc       60

gcccugggcu gccugagccu gcccggcagc agaggcgaga gaccccacag cuucggcagc      120

aacgccguga acaagagcuu cgccaagagc agacagauga gaagcgugga cgugacccug      180

augcccaucg acugcgagcu gagcagcugg agcagcugga ccaccugcga ccccugccag      240

aagaagagau acagauacgc cuaccugcug cagcccagcc aguuccacgg cgagcccugc      300

aacuucagcg acaaggaggu ggaggacugc gugaccaaca gacccugcag aagccaggug      360

agaugcgagg gcuucgugug cgcccagacc ggcagaugcg ugaacagaag acugcugugc      420

aacggcgaca acgacugcgg cgaccagagc gacgaggcca acugcagaag aaucuacaag      480

aagugccagc acgagaugga ccaguacugg ggcaucggca gccuggccag cggcaucaac      540

cuguucacca acagcuucga gggccccgug cuggaccaca gauacuacgc cggcggcugc      600

agcccccacu acauccugaa caccagauuc agaaagcccu acaacgugga gagcuacacc      660

ccccagaccc agggcaagua cgaguucauc cugaaggagu acgagagcua cagcgacuuc      720

gagagaaacg ugaccgagaa gauggccagc aagagcggcu ucagcuucgg cuucaagauc      780

cccggcaucu ucgagcuggg caucagcagc cagagcgaca gaggcaagca cuacaucaga      840

agaaccaaga gauucagcca caccaagagc guguuccugc acgccagaag cgaccuggag      900

guggcccacu acaagcugaa gcccagaagc cugaugcugc acuacgaguu ccugcagaga      960

gugaagagac ugccccugga guacagcuac ggcgaguaca gagaccuguu cagagacuuc     1020

ggcacccacu acaucaccga ggccgugcug ggcggcaucu acgaguacac ccuggugaug     1080

aacaaggagg ccauggagag aggcgacuac acccugaaca acgugcacgc cugcgccaag     1140

aacgacuuca agaucggcgg cgccaucgag gagguguacg ugagccuggg cgugagcgug     1200

ggcaagugca gaggcauccu gaacgagauc aaggacagaa acaagagaga caccauggug     1260

gaggaccugg uggugcuggu gagaggcggc gccagcgagc acaucaccac ccuggccuac     1320

caggagcugc ccaccgccga ccugaugcag gaguggggcg acgccgugca guacaacccc     1380

gccaucauca aggugaaggu ggagccccug uacgagcugg ugaccgccac cgacuucgcc     1440

uacagcagca ccgugagaca gaacaugaag caggcccugg aggaguucca gaaggaggug     1500

agcagcugcc acugcgcccc cugccagggc aacggcgugc ccgugcugaa gggcagcaga     1560

ugcgacugca ucugccccgu gggcagccag ggccuggccu gcgaggugag cuacagaaag     1620

aacaccccca ucgacggcaa guggaacugc uggagcaacu ggagcagcug cagcggcaga     1680

agaaagacca gacagagaca gugcaacaac cccccccccc agaacggcgg cagccccugc     1740

agcggccccg ccagcgagac ccuggacugc agcuga                               1776


<210>  8016
<211>  1776
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CO8B__Homo_sapiens__AAI30576

<400>  8016
augaagaaca gcagaaccug ggccuggcgg gcucccgugg agcuguuccu ccugugcgcc       60

gcgcuuggcu gucugucccu cccugggucu cgcggagaaa gaccgcacag cuuuggcucc      120

aaugcuguca acaaaucuuu cgccaagagc cggcagaugc gcuccguuga cgugacacug      180

augcccaucg auugcgagcu uucuagcugg uccagcugga cgaccuguga cccuugccag      240

aaaaagagau accgguaugc cuaccugcuc caacccucuc aguuucaugg ggaaccuugu      300

aauuucuccg auaaagaggu ggaagacugc gucacaaacc gccccuguag aagccaggug      360

cggugcgagg gauuuguuug ugcucaaacc ggccgcugcg ugaauagacg gcugcugugu      420

aacggggaua augacugcgg agaucagucu gacgaggcca acugccgcag aauuuauaag      480

aagugucagc acgaaaugga ucaguacugg ggcaucggcu cccucgcuag cgggauuaau      540

cuguucacaa acucuuuuga gggaccuguc cuugaccauc gguauuacgc cggcgggugc      600

uccccgcacu auauccugaa uacccgcuuc agaaaacccu acaacgugga aagcuacaca      660

ccucaaaccc agggaaagua ugaguuuauu cucaaagagu acgaauccua uucugauuuc      720

gagcggaaug uuacggaaaa gauggcgagc aaauccggcu uuagcuucgg guuuaagauc      780

cccggaaucu ucgagcuggg cauuucuucc cagagcgaca gaggcaagca uuacauccgc      840

cggaccaaaa gauucucuca cacaaagagc guguuucuuc acgcccgcuc cgaucuggaa      900

gucgcucauu auaaacucaa gccucggucu cugaugcugc acuacgaguu ccuccagaga      960

gugaaacgcc ugccccuuga guauagcuac ggggaauacc gggaccuguu uagagacuuc     1020

ggaacccauu auauuacaga ggccgugcuc ggcgggaucu acgaauauac ccuggucaug     1080

aacaaggagg cuauggaacg cggagauuac acgcuuaaua acguucacgc cugugcgaaa     1140

aacgacuuua agauuggcgg ggccaucgag gagguguaug ugucccuggg agucagcgug     1200

ggcaagugcc ggggcauucu caaugaaauc aaagauagaa acaagcgcga cacaaugguu     1260

gaggaucugg ugguccuggu gagaggggga gcuucugaac acaucaccac acucgccuac     1320

caagagcugc cgaccgcuga ccuuaugcag gaauggggcg augccguuca guauaauccu     1380

gccauuauca aagugaaggu cgagccccug uacgagcucg ugaccgcuac agacuucgcg     1440

uacuccagca cgguccggca aaacaugaaa caggcccugg aagaguuuca gaaggaagug     1500

ucuuccuguc auugcgcucc uugucagggg aauggaguuc ccgugcuuaa gggcagccgg     1560

ugcgauugua uuugccccgu cgggucccaa ggccuggccu gugagguguc uuaucgcaaa     1620

aacaccccua ucgacggaaa guggaauugc uggagcaacu gguccucuug cagcggcaga     1680

cggaaaacaa gacagcgcca guguaauaac ccgcccccuc agaauggggg aucccccugc     1740

agcggcccug ccucugagac ccucgauugu uccuga                               1776


<210>  8017
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CO8G__Homo_sapiens__P07360

<400>  8017

Met Leu Pro Pro Gly Thr Ala Thr Leu Leu Thr Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg Pro Ala Ser Pro 
            20                  25                  30          


Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala Gln Gln Phe Ala 
        35                  40                  45              


Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys Arg Phe Leu Gln 
    50                  55                  60                  


Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His Val Ala Pro Gln 
65                  70                  75                  80  


Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu Asp Gly Ile Cys 
                85                  90                  95      


Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val Leu Gly Arg Phe 
            100                 105                 110         


Leu Leu Gln Ala Arg Asp Ala Arg Gly Ala Val His Val Val Val Ala 
        115                 120                 125             


Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu Glu Arg Ala Gly 
    130                 135                 140                 


Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro Val Ser Asp Ser 
145                 150                 155                 160 


Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala His Leu Thr Glu 
                165                 170                 175     


Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys Glu Ala Ala Asp 
            180                 185                 190         


Gln Phe His Val Leu Asp Glu Val Arg Arg 
        195                 200         


<210>  8018
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CO8G__Homo_sapiens__CCDS7017.1

<400>  8018
augcugcccc cugggacugc gacccucuug acucugcucc uggcagcugg cucgcugggc       60

cagaagccuc agaggccacg ccggcccgca ucccccauca gcaccaucca gcccaaggcc      120

aauuuugaug cucagcaguu ugcagggacc uggcuccuug uggcuguggg cuccgcuugc      180

cguuuccugc aggagcaggg ccaccgggcc gaggccacca cacugcaugu ggcuccccag      240

ggcacagcca uggcugucag uaccuuccga aagcuggaug ggaucugcug gcaggugcgc      300

cagcucuaug gagacacagg gguccucggc cgcuuccugc uucaagcccg agacgcccga      360

ggggcugugc acgugguugu cgcugagacc gacuaccaga guuucgcugu ccuguaccug      420

gagcgggcgg ggcagcuguc agugaagcuc uacgcccgcu cgcucccugu gagcgacucg      480

guccugagug gguuugagca gcggguccag gaggcccacc ugacugagga ccagaucuuc      540

uacuucccca aguacggcuu cugcgaggcu gcagaccagu uccacguccu ggacgaagug      600

aggagguga                                                              609


<210>  8019
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CO8G__Homo_sapiens__CCDS7017.1

<400>  8019
augcugcccc cgggcaccgc cacccuccug acgcugcucc uggccgcggg gagccugggc       60

cagaagcccc agcgcccccg gcgccccgcc uccccgauca gcaccaucca gcccaaggcc      120

aacuucgacg cccagcaguu cgccgggacc uggcuccugg uggcggucgg cuccgccugc      180

cgguuccugc aggagcaggg gcaccgcgcc gaggccacca cgcuccacgu ggcgccccag      240

ggcaccgcca uggccgugag caccuuccgg aagcuggacg gcaucugcug gcagguccgc      300

cagcuguacg gggacaccgg cgugcucggg cgguuccugc ugcaggcccg cgacgcccgg      360

ggcgcggugc acgucguggu ggccgagacg gacuaccagu ccuucgccgu ccucuaccug      420

gagcgcgccg ggcagcugag cgugaagcuc uacgcccggu cccugcccgu gagcgacucc      480

guccugagcg gcuucgagca gcgcgugcag gaggcgcacc ucaccgagga ccagaucuuc      540

uacuucccga aguacggcuu cugcgaggcc gccgaccagu uccacgugcu ggacgagguc      600

cggcgcuga                                                              609


<210>  8020
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CO8G__Homo_sapiens__CCDS7017.1

<400>  8020
augcuccccc ccggcaccgc cacccuccuc acccuccucc ucgccgccgg cucccucggc       60

cagaagcccc agcgcccccg ccgccccgcc ucccccaucu ccaccaucca gcccaaggcc      120

aacuucgacg cccagcaguu cgccggcacc uggcuccucg ucgccgucgg cuccgccugc      180

cgcuuccucc aggagcaggg ccaccgcgcc gaggccacca cccuccacgu cgccccccag      240

ggcaccgcca uggccgucuc caccuuccgc aagcucgacg gcaucugcug gcagguccgc      300

cagcucuacg gcgacaccgg cguccucggc cgcuuccucc uccaggcccg cgacgcccgc      360

ggcgccgucc acgucgucgu cgccgagacc gacuaccagu ccuucgccgu ccucuaccuc      420

gagcgcgccg gccagcucuc cgucaagcuc uacgcccgcu cccuccccgu cuccgacucc      480

guccucuccg gcuucgagca gcgcguccag gaggcccacc ucaccgagga ccagaucuuc      540

uacuucccca aguacggcuu cugcgaggcc gccgaccagu uccacguccu cgacgagguc      600

cgccgcuga                                                              609


<210>  8021
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CO8G__Homo_sapiens__CCDS7017.1

<400>  8021
augcugcccc cuggcaccgc cacacuccuu acucuguugu uagcugcagg gagccuggga       60

cagaagccac aaagaccgag gcggcccgcc uccccuaucu cuacgauuca gccaaaagcg      120

aacuucgacg cucagcaguu ugccgguacc uggcuacucg uggcagucgg cucagccugc      180

cgcuuccugc aagagcaggg gcaccgagcu gaagcaacaa cucuucaugu ugcuccccag      240

ggaaccgcca uggccgugag uacauuucgu aagcuggaug gcauauguug gcagguaaga      300

caauuguacg gugacaccgg ggugcucgga agguuccugc ugcaggcgcg ggaugcacgc      360

ggcgccgucc acgugguugu ggcugagacu gacuaucaga gcuuugccgu ccucuacuua      420

gaaagagcag gccagcuguc cgugaaacuu uaugcuaggu cuuugccugu aucggauuca      480

guucugagcg gguucgagca acgggugcag gaagcccauc uaacagagga ccagaucuuu      540

uacuucccaa aguauggauu uugcgaggcg gccgaucaau uccacguccu cgacgaagug      600

cgccgauga                                                              609


<210>  8022
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CO8G__Homo_sapiens__CCDS7017.1

<400>  8022
augcugcccc ccggcaccgc cacccugcug acccugcugc uggccgccgg cagccugggc       60

cagaagcccc agagacccag aagacccgcc agccccauca gcaccaucca gcccaaggcc      120

aacuucgacg cccagcaguu cgccggcacc uggcugcugg uggccguggg cagcgccugc      180

agauuccugc aggagcaggg ccacagagcc gaggccacca cccugcacgu ggccccccag      240

ggcaccgcca uggccgugag caccuucaga aagcuggacg gcaucugcug gcaggugaga      300

cagcuguacg gcgacaccgg cgugcugggc agauuccugc ugcaggccag agacgccaga      360

ggcgccgugc acgugguggu ggccgagacc gacuaccaga gcuucgccgu gcuguaccug      420

gagagagccg gccagcugag cgugaagcug uacgccagaa gccugcccgu gagcgacagc      480

gugcugagcg gcuucgagca gagagugcag gaggcccacc ugaccgagga ccagaucuuc      540

uacuucccca aguacggcuu cugcgaggcc gccgaccagu uccacgugcu ggacgaggug      600

agaagauga                                                              609


<210>  8023
<211>  609
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CO8G__Homo_sapiens__CCDS7017.1

<400>  8023
augcugcccc cuggcaccgc cacacuccug acgcuucugc ucgcugccgg gagccuggga       60

cagaagccgc aaagaccccg gcgcccugcg ucccccauuu cuaccauuca gccuaaagcu      120

aacuucgacg cccagcaguu ugccggcaca uggcuucugg uggcugucgg gagcgccugc      180

agauuccucc aagagcaggg acaccgggcu gaagccacca cacugcaugu ugcgccccag      240

ggcaccgcca uggcuguguc cacauuucgc aagcuggaug ggaucuguug gcaagugaga      300

cagcucuacg gagacaccgg cguccugggc cgguuccuuc ugcaggcccg cgaugcuaga      360

ggggccgugc acguuguggu cgcggagacg gacuaucagu cuuuugccgu gcucuaccug      420

gaacgggcug gacagcuuag cguuaaacug uaugcccgcu cccucccugu gucugauagc      480

guccuguccg gcuucgagca aagagugcag gaagcucauc ugaccgagga ccagaucuuu      540

uacuucccga aguauggguu uugcgaggcc gccgaucaau uccacgugcu cgacgaaguc      600

cggcgcuga                                                              609


<210>  8024
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1INH__Homo_sapiens__P05155

<400>  8024

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  8025
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8025
auggccucca ggcugacccu gcugacccuc cugcugcugc ugcuggcugg ggauagagcc       60

uccucaaauc caaaugcuac cagcuccagc ucccaggauc cagagaguuu gcaagacaga      120

ggcgaaggga aggucgcaac aacaguuauc uccaagaugc uauucguuga acccauccug      180

gagguuucca gcuugccgac aaccaacuca acaaccaauu cagccaccaa aauaacagcu      240

aauaccacug augaacccac cacacaaccc accacagagc ccaccaccca acccaccauc      300

caacccaccc aaccaacuac ccagcuccca acagauucuc cuacccagcc cacuacuggg      360

uccuucugcc caggaccugu uacucucugc ucugacuugg agagucauuc aacagaggcc      420

guguuggggg augcuuuggu agauuucucc cugaagcucu accacgccuu cucagcaaug      480

aagaaggugg agaccaacau ggccuuuucc ccauucagca ucgccagccu ccuuacccag      540

guccugcucg gggcugggga gaacaccaaa acaaaccugg agagcauccu cucuuacccc      600

aaggacuuca ccugugucca ccaggcccug aagggcuuca cgaccaaagg ugucaccuca      660

gucucucaga ucuuccacag cccagaccug gccauaaggg acaccuuugu gaaugccucu      720

cggacccugu acagcagcag ccccagaguc cuaagcaaca acagugacgc caacuuggag      780

cucaucaaca ccuggguggc caagaacacc aacaacaaga ucagccggcu gcuagacagu      840

cugcccuccg auacccgccu uguccuccuc aaugcuaucu accugagugc caaguggaag      900

acaacauuug aucccaagaa aaccagaaug gaacccuuuc acuucaaaaa cucaguuaua      960

aaagugccca ugaugaauag caagaaguac ccuguggccc auuucauuga ccaaacuuug     1020

aaagccaagg uggggcagcu gcagcucucc cacaaucuga guuuggugau ccugguaccc     1080

cagaaccuga aacaucgucu ugaagacaug gaacaggcuc ucagcccuuc uguuuucaag     1140

gccaucaugg agaaacugga gauguccaag uuccagccca cucuccuaac acuaccccgc     1200

aucaaaguga cgaccagcca ggauaugcuc ucaaucaugg agaaauugga auucuucgau     1260

uuuucuuaug accuuaaccu gugugggcug acagaggacc cagaucuuca gguuucugcg     1320

augcagcacc agacagugcu ggaacugaca gagacugggg uggaggcggc ugcagccucc     1380

gccaucucug uggcccgcac ccugcugguc uuugaagugc agcagcccuu ccucuucgug     1440

cucugggacc agcagcacaa guucccuguc uucauggggc gaguauauga ccccagggcc     1500

uga                                                                   1503


<210>  8026
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8026
auggccagcc gccugacccu ccugacccug cuccugcugc uccuggccgg cgaccgggcg       60

uccagcaacc ccaacgccac guccagcucc agccaggacc cggagucccu gcaggaccgc      120

ggggagggca agguggccac caccgucauc agcaagaugc uguucgugga gcccauccug      180

gaggugucca gccugcccac cacgaacucc accaccaaca gcgccaccaa gaucacggcc      240

aacaccaccg acgagcccac cacgcagccg accaccgagc ccaccacgca gcccaccauc      300

cagcccaccc agccgaccac gcagcucccc accgacuccc ccacccagcc caccacgggg      360

agcuucugcc cgggccccgu cacccugugc uccgaccugg agagccacuc caccgaggcg      420

gugcucgggg acgcccuggu ggacuucagc cugaagcucu accacgccuu cuccgccaug      480

aagaaggucg agaccaacau ggcguucagc cccuucagca ucgccucccu gcugacccag      540

gugcuccugg gcgccggcga gaacaccaag accaaccugg agagcauccu cuccuacccc      600

aaggacuuca cgugcgugca ccaggcccug aagggguuca cgaccaaggg cgucaccagc      660

gugucccaga ucuuccacag cccggaccug gccauccggg acaccuucgu gaacgcgucc      720

cgcacgcucu acagcuccag cccccggguc cuguccaaca acagcgacgc caaccuggag      780

cucaucaaca ccuggguggc caagaacacc aacaacaaga ucucccgccu gcuggacagc      840

cuccccuccg acacccggcu ggugcugcuc aacgccaucu accugagcgc caaguggaag      900

accacguucg accccaagaa gacccgcaug gagccguucc acuucaagaa cuccgucauc      960

aaggugccca ugaugaacag caagaaguac cccguggcgc acuucaucga ccagacccug     1020

aaggccaagg ucgggcagcu ccagcugucc cacaaccuga gccucgugau ccuggugccc     1080

cagaaccuga agcaccggcu cgaggacaug gagcaggccc ugagcccguc cgucuucaag     1140

gccaucaugg agaagcugga gaugagcaag uuccagccca cccuccugac gcugccccgc     1200

aucaagguga ccaccuccca ggacaugcug agcaucaugg agaagcucga guucuucgac     1260

uucuccuacg accugaaccu gugcggccuc accgaggacc ccgaccucca ggugagcgcc     1320

augcagcacc agacgguccu ggagcucacc gagaccgggg uggaggcggc cgccgccucc     1380

gccaucagcg ucgcgcggac ccugcuggug uucgaggugc agcagccguu ccucuucguc     1440

cugugggacc agcagcacaa guuccccgug uucaugggcc gcguguacga cccccgggcc     1500

uga                                                                   1503


<210>  8027
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8027
auggccuccc gccucacccu ccucacccuc cuccuccucc uccucgccgg cgaccgcgcc       60

uccuccaacc ccaacgccac cuccuccucc ucccaggacc ccgagucccu ccaggaccgc      120

ggcgagggca aggucgccac caccgucauc uccaagaugc ucuucgucga gcccauccuc      180

gaggucuccu cccuccccac caccaacucc accaccaacu ccgccaccaa gaucaccgcc      240

aacaccaccg acgagcccac cacccagccc accaccgagc ccaccaccca gcccaccauc      300

cagcccaccc agcccaccac ccagcucccc accgacuccc ccacccagcc caccaccggc      360

uccuucugcc ccggccccgu cacccucugc uccgaccucg agucccacuc caccgaggcc      420

guccucggcg acgcccucgu cgacuucucc cucaagcucu accacgccuu cuccgccaug      480

aagaaggucg agaccaacau ggccuucucc cccuucucca ucgccucccu ccucacccag      540

guccuccucg gcgccggcga gaacaccaag accaaccucg aguccauccu cuccuacccc      600

aaggacuuca ccugcgucca ccaggcccuc aagggcuuca ccaccaaggg cgucaccucc      660

gucucccaga ucuuccacuc ccccgaccuc gccauccgcg acaccuucgu caacgccucc      720

cgcacccucu acuccuccuc cccccgcguc cucuccaaca acuccgacgc caaccucgag      780

cucaucaaca ccugggucgc caagaacacc aacaacaaga ucucccgccu ccucgacucc      840

cuccccuccg acacccgccu cguccuccuc aacgccaucu accucuccgc caaguggaag      900

accaccuucg accccaagaa gacccgcaug gagcccuucc acuucaagaa cuccgucauc      960

aaggucccca ugaugaacuc caagaaguac cccgucgccc acuucaucga ccagacccuc     1020

aaggccaagg ucggccagcu ccagcucucc cacaaccucu cccucgucau ccucgucccc     1080

cagaaccuca agcaccgccu cgaggacaug gagcaggccc ucucccccuc cgucuucaag     1140

gccaucaugg agaagcucga gauguccaag uuccagccca cccuccucac ccucccccgc     1200

aucaagguca ccaccuccca ggacaugcuc uccaucaugg agaagcucga guucuucgac     1260

uucuccuacg accucaaccu cugcggccuc accgaggacc ccgaccucca ggucuccgcc     1320

augcagcacc agaccguccu cgagcucacc gagaccggcg ucgaggccgc cgccgccucc     1380

gccaucuccg ucgcccgcac ccuccucguc uucgaggucc agcagcccuu ccucuucguc     1440

cucugggacc agcagcacaa guuccccguc uucaugggcc gcgucuacga cccccgcgcc     1500

uga                                                                   1503


<210>  8028
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8028
auggccagca gacugacccu ccuuacacug uuguuacugc uacucgcugg cgacagggca       60

uccucuaacc ccaaugccac uucaaguagc ucccaggauc cugagucucu gcaagaccgc      120

ggggaaggaa agguggcgac gaccgucauc ucgaaaaugc uuuucguuga gccaauucug      180

gaagugagcu cauugccgac aacuaacagu accacaaauu ccgcuaccaa gauaacugcc      240

aacacaaccg augagcccac gacucagccu accacagaac caacuaccca gcccacaauc      300

cagccuaccc aaccaacgac ucagcucccc acagacucuc cuacccagcc aacuacaggu      360

agcuuuugcc cgggccccgu aacccugugu uccgaucugg agucacacag uacggaggca      420

gugcucgggg acgccuuagu cgauuucagc cugaaacuuu accaugcuuu uucugcaaug      480

aagaaagugg aaaccaauau ggccuucucc ccuuuuucaa uugcuagcuu gcugacacag      540

guucuacucg gagccggcga gaacacuaag accaaucugg aaaguauccu uucuuaucca      600

aaggacuuca caugcgugca ccaagcgcug aaagguuuua cuaccaaggg ggucacaucc      660

gugagccaga uuuuccauuc gcccgauuug gcaauccggg acaccuuugu aaacgccucu      720

cgaacucucu acuccucaag uccucguguu cugagcaaua acuccgaugc uaauuuagag      780

cugauaaaca cguggguggc caaaaauaca aacaauaaga ucucuagacu ccuugacagc      840

cugccaucag auaccagguu gguccuacug aacgcaauuu aucucagugc uaaauggaag      900

acuaccuucg accccaagaa aacacggaug gagccguuuc acuucaagaa cuccgugauc      960

aaagugccua ugaugaauag caagaaauac cccgucgccc auuuuauuga ccagacccug     1020

aaggcgaaag uuggacagcu ucaacugucu cacaacuugu cacucgugau ccugguacca     1080

cagaauuuaa agcaccgccu ggaagauaug gagcaggccc uaaguccuag cguguucaag     1140

gcaauaaugg aaaaacucga gauguccaag uuccaaccca cucugcuuac auugccaaga     1200

auuaaaguca cgaccucuca ggacaugcug ucgaucaugg aaaagcucga guuuuucgau     1260

uuuagcuaug accugaaccu uuguggccug acugaggauc ccgaccucca gguguccgcu     1320

augcagcauc aaacaguuuu ggaacugacc gagacaggcg uggaagccgc ugccgcauca     1380

gccauuagug ucgcuaggac uuuacuggug uucgagguac agcagccuuu ucuauucguu     1440

cucugggauc agcaacacaa auuuccagug uucauggggc gggucuacga cccgcgcgcg     1500

uga                                                                   1503


<210>  8029
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8029
auggccagca gacugacccu gcugacccug cugcugcugc ugcuggccgg cgacagagcc       60

agcagcaacc ccaacgccac cagcagcagc agccaggacc ccgagagccu gcaggacaga      120

ggcgagggca agguggccac caccgugauc agcaagaugc uguucgugga gcccauccug      180

gaggugagca gccugcccac caccaacagc accaccaaca gcgccaccaa gaucaccgcc      240

aacaccaccg acgagcccac cacccagccc accaccgagc ccaccaccca gcccaccauc      300

cagcccaccc agcccaccac ccagcugccc accgacagcc ccacccagcc caccaccggc      360

agcuucugcc ccggccccgu gacccugugc agcgaccugg agagccacag caccgaggcc      420

gugcugggcg acgcccuggu ggacuucagc cugaagcugu accacgccuu cagcgccaug      480

aagaaggugg agaccaacau ggccuucagc cccuucagca ucgccagccu gcugacccag      540

gugcugcugg gcgccggcga gaacaccaag accaaccugg agagcauccu gagcuacccc      600

aaggacuuca ccugcgugca ccaggcccug aagggcuuca ccaccaaggg cgugaccagc      660

gugagccaga ucuuccacag ccccgaccug gccaucagag acaccuucgu gaacgccagc      720

agaacccugu acagcagcag ccccagagug cugagcaaca acagcgacgc caaccuggag      780

cugaucaaca ccuggguggc caagaacacc aacaacaaga ucagcagacu gcuggacagc      840

cugcccagcg acaccagacu ggugcugcug aacgccaucu accugagcgc caaguggaag      900

accaccuucg accccaagaa gaccagaaug gagcccuucc acuucaagaa cagcgugauc      960

aaggugccca ugaugaacag caagaaguac cccguggccc acuucaucga ccagacccug     1020

aaggccaagg ugggccagcu gcagcugagc cacaaccuga gccuggugau ccuggugccc     1080

cagaaccuga agcacagacu ggaggacaug gagcaggccc ugagccccag cguguucaag     1140

gccaucaugg agaagcugga gaugagcaag uuccagccca cccugcugac ccugcccaga     1200

aucaagguga ccaccagcca ggacaugcug agcaucaugg agaagcugga guucuucgac     1260

uucagcuacg accugaaccu gugcggccug accgaggacc ccgaccugca ggugagcgcc     1320

augcagcacc agaccgugcu ggagcugacc gagaccggcg uggaggccgc cgccgccagc     1380

gccaucagcg uggccagaac ccugcuggug uucgaggugc agcagcccuu ccuguucgug     1440

cugugggacc agcagcacaa guuccccgug uucaugggca gaguguacga ccccagagcc     1500

uga                                                                   1503


<210>  8030
<211>  1503
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C1INH__Homo_sapiens__AAM21515

<400>  8030
auggccagca gacugacccu ccugacacuu cugcuccugc uucuggcugg cgaccgggcc       60

uccucuaacc ccaaugcgac gagcuccucu agccaggauc cugagucccu ccaagaccgc      120

ggggaaggaa agguggcuac cacagucauc ucuaaaaugc uguucguuga gccgauucug      180

gaagugagcu cccuccccac cacaaacagc accacaaauu cugccaccaa gaucacggcc      240

aacaccacag augagccuac cacacagccc accacggaac cuacaaccca gcccacaauu      300

cagccuaccc aaccgaccac acagcugccc acggacuccc cuacccagcc cacaaccggc      360

agcuuuugcc cugggcccgu gacacuuugu ucugaucugg agucccacag caccgaggcu      420

guccucggag acgcccuggu ggauuucucu cuuaaacugu accaugcuuu uuccgccaug      480

aagaaaguug aaacgaauau ggcguucagc ccguuuucca ucgccucucu ccugacacag      540

gugcugcucg gcgcugggga gaacaccaag accaaucugg aaagcauucu uuccuauccu      600

aaggacuuca caugcgucca ccaagcccug aaaggauuua ccacaaaggg cgugacgagc      660

guuucucaga ucuuccauuc ccccgaucuc gcuaucagag acaccuuugu gaacgccagc      720

cggacacugu acucuagcuc cccucgcguc cuuucuaaua acagcgaugc gaaucuggag      780

cucauuaaca ccuggguggc caaaaauaca aacaauaaga ucuccagacu gcuggacagc      840

cuccccucug auacccggcu ggugcuucug aacgcuauuu aucucuccgc caaauggaag      900

acgaccuucg accccaagaa aacacgcaug gagccuuuuc acuucaagaa cagcgucauc      960

aaaguuccga ugaugaacuc uaagaaauac cccguggcuc auuuuauuga ccagacccug     1020

aaggccaaag ugggccagcu ucaacugucc cacaaucuca gccuggucau ccuggugccu     1080

cagaaucuca agcacagacu ggaagauaug gagcaggccc uuucccccuc uguuuucaag     1140

gcuauuaugg aaaaacugga gaugagcaag uuccaaccua cacuccugac ccugccccgg     1200

aucaaaguga cgacauccca ggacaugcuu ucuaucaugg aaaagcucga guuuuucgau     1260

uuuagcuaug accugaaccu gugugggcuc accgaggauc cggaccugca ggucuccgcg     1320

augcagcauc aaacagugcu ugaacugacc gagaccggag uugaagccgc ugccgccagc     1380

gcuauuucug uggcccgcac acuccugguc uucgaggugc agcagccuuu ucuguucguc     1440

cuuugggauc agcaacacaa auuucccgug uucaugggca gaguuuacga cccucgggcg     1500

uga                                                                   1503


<210>  8031
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1qR__Homo_sapiens__Q8IXK1

<400>  8031

Met Ala Thr Ser Met Gly Leu Leu Leu Leu Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Gln Pro Gly Ala Gly Thr Gly Ala Asp Thr Glu Ala Val Val Cys Val 
            20                  25                  30          


Gly Thr Ala Cys Tyr Thr Ala His Ser Gly Lys Leu Ser Ala Ala Glu 
        35                  40                  45              


Ala Gln Asn His Cys Asn Gln Asn Gly Gly Asn Leu Ala Thr Val Lys 
    50                  55                  60                  


Ser Lys Glu Glu Ala Gln His Val Gln Arg Val Leu Ala Gln Leu Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Ala Leu Thr Ala Arg Met Ser Lys Phe Trp Ile Gly 
                85                  90                  95      


Leu Gln Arg Glu Lys Gly Lys Cys Leu Asp Pro Ser Leu Pro Leu Lys 
            100                 105                 110         


Gly Phe Ser Trp Val Gly Gly Gly Glu Asp Thr Pro Tyr Ser Asn Trp 
        115                 120                 125             


His Lys Glu Leu Arg Asn Ser Cys Ile Ser Lys Arg Cys Val Ser Leu 
    130                 135                 140                 


Leu Leu Asp Leu Ser Gln Pro Leu Leu Pro Ser Arg Leu Pro Lys Trp 
145                 150                 155                 160 


Ser Glu Gly Pro Cys Gly Ser Pro Gly Ser Pro Gly Ser Asn Ile Glu 
                165                 170                 175     


Gly Phe Val Cys Lys Phe Ser Phe Lys Gly Met Cys Arg Pro Leu Ala 
            180                 185                 190         


Leu Gly Gly Pro Gly Gln Val Thr Tyr Thr Thr Pro Phe Gln Thr Thr 
        195                 200                 205             


Ser Ser Ser Leu Glu Ala Val Pro Phe Ala Ser Ala Ala Asn Val Ala 
    210                 215                 220                 


Cys Gly Glu Gly Asp Lys Asp Glu Thr Gln Ser His Tyr Phe Leu Cys 
225                 230                 235                 240 


Lys Glu Lys Ala Pro Asp Val Phe Asp Trp Gly Ser Ser Gly Pro Leu 
                245                 250                 255     


Cys Val Ser Pro Lys Tyr Gly Cys Asn Phe Asn Asn Gly Gly Cys His 
            260                 265                 270         


Gln Asp Cys Phe Glu Gly Gly Asp Gly Ser Phe Leu Cys Gly Cys Arg 
        275                 280                 285             


Pro Gly Phe Arg Leu Leu Asp Asp Leu Val Thr Cys Ala Ser Arg Asn 
    290                 295                 300                 


Pro Cys Ser Ser Ser Pro Cys Arg Gly Gly Ala Thr Cys Ala Leu Gly 
305                 310                 315                 320 


Pro His Gly Lys Asn Tyr Thr Cys Arg Cys Pro Gln Gly Tyr Gln Leu 
                325                 330                 335     


Asp Ser Ser Gln Leu Asp Cys Val Asp Val Asp Glu Cys Gln Asp Ser 
            340                 345                 350         


Pro Cys Ala Gln Glu Cys Val Asn Thr Pro Gly Gly Phe Arg Cys Glu 
        355                 360                 365             


Cys Trp Val Gly Tyr Glu Pro Gly Gly Pro Gly Glu Gly Ala Cys Gln 
    370                 375                 380                 


Asp Val Asp Glu Cys Ala Leu Gly Arg Ser Pro Cys Ala Gln Gly Cys 
385                 390                 395                 400 


Thr Asn Thr Asp Gly Ser Phe His Cys Ser Cys Glu Glu Gly Tyr Val 
                405                 410                 415     


Leu Ala Gly Glu Asp Gly Thr Gln Cys Gln Asp Val Asp Glu Cys Val 
            420                 425                 430         


Gly Pro Gly Gly Pro Leu Cys Asp Ser Leu Cys Phe Asn Thr Gln Gly 
        435                 440                 445             


Ser Phe His Cys Gly Cys Leu Pro Gly Trp Val Leu Ala Pro Asn Gly 
    450                 455                 460                 


Val Ser Cys Thr Met Gly Pro Val Ser Leu Gly Pro Pro Ser Gly Pro 
465                 470                 475                 480 


Pro Asp Glu Glu Asp Lys Gly Glu Lys Glu Gly Ser Thr Val Pro Arg 
                485                 490                 495     


Ala Ala Thr Ala Ser Pro Thr Arg Gly Pro Glu Gly Thr Pro Lys Ala 
            500                 505                 510         


Thr Pro Thr Thr Ser Arg Pro Ser Leu Ser Ser Asp Ala Pro Ile Thr 
        515                 520                 525             


Ser Ala Pro Leu Lys Met Leu Ala Pro Ser Gly Ser Ser Gly Val Trp 
    530                 535                 540                 


Arg Glu Pro Ser Ile His His Ala Thr Ala Ala Ser Gly Pro Gln Glu 
545                 550                 555                 560 


Pro Ala Gly Gly Asp Ser Ser Val Ala Thr Gln Asn Asn Asp Gly Thr 
                565                 570                 575     


Asp Gly Gln Lys Leu Leu Leu Phe Tyr Ile Leu Gly Thr Val Val Ala 
            580                 585                 590         


Ile Leu Leu Leu Leu Ala Leu Ala Leu Gly Leu Leu Val Tyr Arg Lys 
        595                 600                 605             


Arg Arg Ala Lys Arg Glu Glu Lys Lys Glu Lys Lys Pro Gln Asn Ala 
    610                 615                 620                 


Ala Asp Ser Tyr Ser Trp Val Pro Glu Arg Ala Glu Ser Arg Ala Met 
625                 630                 635                 640 


Glu Asn Gln Tyr Ser Pro Thr Pro Gly Thr Asp Cys 
                645                 650         


<210>  8032
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8032
auggccaccu ccaugggccu gcugcugcug cugcugcugc uccugaccca gcccggggcg       60

gggacgggag cugacacgga ggcggugguc ugcgugggga ccgccugcua cacggcccac      120

ucgggcaagc ugagcgcugc cgaggcccag aaccacugca accagaacgg gggcaaccug      180

gccacuguga agagcaagga ggaggcccag cacguccagc gaguacuggc ccagcuccug      240

aggcgggagg cagcccugac ggcgaggaug agcaaguucu ggauugggcu ccagcgagag      300

aagggcaagu gccuggaccc uagucugccg cugaagggcu ucagcugggu gggcgggggg      360

gaggacacgc cuuacucuaa cuggcacaag gagcuccgga acucgugcau cuccaagcgc      420

ugugugucuc ugcugcugga ccugucccag ccgcuccuuc ccagccgccu ccccaagugg      480

ucugagggcc ccugugggag cccaggcucc cccggaagua acauugaggg cuucgugugc      540

aaguucagcu ucaaaggcau gugccggccu cuggcccugg ggggcccagg ucaggugacc      600

uacaccaccc ccuuccagac caccaguucc uccuuggagg cugugcccuu ugccucugcg      660

gccaauguag ccugugggga aggugacaag gacgagacuc agagucauua uuuccugugc      720

aaggagaagg cccccgaugu guucgacugg ggcagcucgg gcccccucug ugucagcccc      780

aaguauggcu gcaacuucaa caaugggggc ugccaccagg acugcuuuga agggggggau      840

ggcuccuucc ucugcggcug ccgaccagga uuccggcugc uggaugaccu ggugaccugu      900

gccucucgaa acccuugcag cuccagccca ugucgugggg gggccacgug cgcccuggga      960

ccccauggga aaaacuacac gugccgcugc ccccaagggu accagcugga cucgagucag     1020

cuggacugug uggacgugga ugaaugccag gacucccccu gugcccagga gugugucaac     1080

accccugggg gcuuccgcug cgaaugcugg guuggcuaug agccgggcgg uccuggagag     1140

ggggccuguc aggaugugga ugagugugcu cugggucgcu cgccuugcgc ccagggcugc     1200

accaacacag auggcucauu ucacugcucc ugugaggagg gcuacguccu ggccggggag     1260

gacgggacuc agugccagga cguggaugag ugugugggcc cggggggccc ccucugcgac     1320

agcuugugcu ucaacacaca aggguccuuc cacuguggcu gccugccagg cugggugcug     1380

gccccaaaug gggucucuug caccaugggg ccugugucuc ugggaccacc aucugggccc     1440

cccgaugagg aggacaaagg agagaaagaa gggagcaccg ugccccgcgc ugcaacagcc     1500

agucccacaa ggggccccga gggcaccccc aaggcuacac ccaccacaag uagaccuucg     1560

cugucaucug acgcccccau cacaucugcc ccacucaaga ugcuggcccc cagugggucc     1620

ucaggcgucu ggagggagcc cagcauccau cacgccacag cugccucugg cccccaggag     1680

ccugcaggug gggacuccuc cguggccaca caaaacaacg auggcacuga cgggcaaaag     1740

cugcuuuuau ucuacauccu aggcaccgug guggccaucc uacuccugcu ggcccuggcu     1800

cuggggcuac uggucuaucg caagcggaga gcgaagaggg aggagaagaa ggagaagaag     1860

ccccagaaug cggcagacag uuacuccugg guuccagagc gagcugagag cagggccaug     1920

gagaaccagu acaguccgac accugggaca gacugcuga                            1959


<210>  8033
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8033
auggccacca gcaugggccu gcuccugcug cuccugcugc uccugaccca gcccggggcc       60

ggcacggggg cggacaccga ggccgugguc ugcgugggca ccgccugcua caccgcccac      120

uccgggaagc ugagcgccgc ggaggcccag aaccacugca accagaacgg cggcaaccuc      180

gccacgguga aguccaagga ggaggcccag cacguccagc gcgugcuggc gcagcugcuc      240

cggcgcgagg ccgcccugac cgcccggaug agcaaguucu ggaucgggcu gcagcgcgag      300

aagggcaagu gccucgaccc gucccugccc cugaaggggu ucagcugggu gggcgggggc      360

gaggacaccc ccuacuccaa cuggcacaag gagcuccgga acagcugcau cuccaagcgc      420

ugcgucagcc ugcugcucga ccugucccag ccccugcucc cgagccggcu gcccaagugg      480

uccgagggcc ccugcgggag ccccggcucc ccggggagca acaucgaggg cuucgugugc      540

aaguucuccu ucaagggcau gugccgcccc cuggcccucg ggggccccgg ccaggugacc      600

uacacgaccc ccuuccagac caccagcucc agccuggagg cggucccguu cgccagcgcc      660

gccaacgugg ccugcgggga gggggacaag gacgagacgc agucccacua cuuccugugc      720

aaggagaagg cgcccgacgu guucgacugg ggcagcuccg gcccccucug cgucagcccc      780

aaguacgggu gcaacuucaa caacggcggg ugccaccagg acugcuucga gggcggggac      840

ggcuccuucc ugugcggcug ccggccgggg uuccgccugc ucgacgaccu ggugaccugc      900

gccagccgga accccugcuc cagcuccccc ugccgcggcg gggcgaccug cgcccugggc      960

ccccacggga agaacuacac gugccggugc ccgcagggcu accagcucga cagcucccag     1020

cuggacugcg uggacgucga cgagugccag gacagccccu gcgcccagga gugcgugaac     1080

acccccggcg gguuccgcug cgagugcugg gugggcuacg agcccggggg cccgggcgag     1140

ggggccugcc aggacgucga cgagugcgcc cugggccggu cccccugcgc ccaggggugc     1200

accaacaccg acggcagcuu ccacugcucc ugcgaggagg gguacgugcu cgccggcgag     1260

gacggcaccc agugccagga cguggacgag ugcgucgggc ccggcgggcc ccugugcgac     1320

agccugugcu ucaacacgca gggcuccuuc cacugcgggu gccucccggg cugggugcug     1380

gcccccaacg gcgugagcug caccaugggg cccgucuccc ugggcccgcc cagcgggccg     1440

cccgacgagg aggacaaggg cgagaaggag gggagcaccg ugccccgcgc ggccaccgcc     1500

ucccccacgc ggggccccga gggcaccccc aaggccaccc cgaccacgag ccgccccucc     1560

cucagcuccg acgcgcccau caccagcgcg ccccugaaga ugcuggcccc guccgggagc     1620

uccggcgucu ggcgggagcc cagcauccac cacgccaccg ccgccuccgg gccccaggag     1680

cccgccggcg gggacagcuc cguggccacc cagaacaacg acggcacgga cggccagaag     1740

cuccugcugu ucuacauccu ggggaccgug gucgccaucc uccugcugcu cgcccuggcg     1800

cugggccucc ugguguaccg caagcggcgc gccaagcgcg aggagaagaa ggagaagaag     1860

ccgcagaacg ccgccgacag cuacuccugg gugcccgagc gggccgagag ccgcgcgaug     1920

gagaaccagu acucccccac ccccgggacc gacugcuga                            1959


<210>  8034
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8034
auggccaccu ccaugggccu ccuccuccuc cuccuccucc uccucaccca gcccggcgcc       60

ggcaccggcg ccgacaccga ggccgucguc ugcgucggca ccgccugcua caccgcccac      120

uccggcaagc ucuccgccgc cgaggcccag aaccacugca accagaacgg cggcaaccuc      180

gccaccguca aguccaagga ggaggcccag cacguccagc gcguccucgc ccagcuccuc      240

cgccgcgagg ccgcccucac cgcccgcaug uccaaguucu ggaucggccu ccagcgcgag      300

aagggcaagu gccucgaccc cucccucccc cucaagggcu ucuccugggu cggcggcggc      360

gaggacaccc ccuacuccaa cuggcacaag gagcuccgca acuccugcau cuccaagcgc      420

ugcgucuccc uccuccucga ccucucccag ccccuccucc ccucccgccu ccccaagugg      480

uccgagggcc ccugcggcuc ccccggcucc cccggcucca acaucgaggg cuucgucugc      540

aaguucuccu ucaagggcau gugccgcccc cucgcccucg gcggccccgg ccaggucacc      600

uacaccaccc ccuuccagac caccuccucc ucccucgagg ccguccccuu cgccuccgcc      660

gccaacgucg ccugcggcga gggcgacaag gacgagaccc agucccacua cuuccucugc      720

aaggagaagg cccccgacgu cuucgacugg ggcuccuccg gcccccucug cgucuccccc      780

aaguacggcu gcaacuucaa caacggcggc ugccaccagg acugcuucga gggcggcgac      840

ggcuccuucc ucugcggcug ccgccccggc uuccgccucc ucgacgaccu cgucaccugc      900

gccucccgca accccugcuc cuccuccccc ugccgcggcg gcgccaccug cgcccucggc      960

ccccacggca agaacuacac cugccgcugc ccccagggcu accagcucga cuccucccag     1020

cucgacugcg ucgacgucga cgagugccag gacucccccu gcgcccagga gugcgucaac     1080

acccccggcg gcuuccgcug cgagugcugg gucggcuacg agcccggcgg ccccggcgag     1140

ggcgccugcc aggacgucga cgagugcgcc cucggccgcu cccccugcgc ccagggcugc     1200

accaacaccg acggcuccuu ccacugcucc ugcgaggagg gcuacguccu cgccggcgag     1260

gacggcaccc agugccagga cgucgacgag ugcgucggcc ccggcggccc ccucugcgac     1320

ucccucugcu ucaacaccca gggcuccuuc cacugcggcu gccuccccgg cuggguccuc     1380

gcccccaacg gcgucuccug caccaugggc cccgucuccc ucggcccccc cuccggcccc     1440

cccgacgagg aggacaaggg cgagaaggag ggcuccaccg ucccccgcgc cgccaccgcc     1500

ucccccaccc gcggccccga gggcaccccc aaggccaccc ccaccaccuc ccgccccucc     1560

cucuccuccg acgcccccau caccuccgcc ccccucaaga ugcucgcccc cuccggcucc     1620

uccggcgucu ggcgcgagcc cuccauccac cacgccaccg ccgccuccgg cccccaggag     1680

cccgccggcg gcgacuccuc cgucgccacc cagaacaacg acggcaccga cggccagaag     1740

cuccuccucu ucuacauccu cggcaccguc gucgccaucc uccuccuccu cgcccucgcc     1800

cucggccucc ucgucuaccg caagcgccgc gccaagcgcg aggagaagaa ggagaagaag     1860

ccccagaacg ccgccgacuc cuacuccugg guccccgagc gcgccgaguc ccgcgccaug     1920

gagaaccagu acucccccac ccccggcacc gacugcuga                            1959


<210>  8035
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8035
auggccacca gcaugggccu gcuccuucug uuguuacugc uacucacaca gcccggggcu       60

ggaacuggug cagacacgga ggccgugguc ugcguuggca ccgcguguua cacagcucac      120

uccgggaagc ugucugccgc agaagcccaa aaccauugca aucagaacgg aggcaaucuu      180

gcuacuguga aaucaaagga ggaagcacag cacguacaga gagugcuggc ccaauugcuc      240

aggcgggagg cugcccugac cgcgcgcaug aguaaauucu ggaucggucu gcagcgagaa      300

aaggggaaau gucucgaucc uagcuuacca cugaagggau uuuccugggu cggcggcggg      360

gaggacacac cguauucuaa cuggcauaag gagcuucgua auucgugcau uucaaaaaga      420

ugugugagcu ugcugcuaga ucucagucag ccccugcuuc cuuccaggcu gccaaagugg      480

ucugaaggac ccugcgguag cccuggcucc ccagggucaa acauagaggg auucguuugu      540

aaauuuaguu ucaagggcau gugccggccc uuggcacucg gugggccugg acaggugacc      600

uacacuacac cauuucaaac cacgucuagc ucccuggaag ccgucccguu cgcuucagcc      660

gcaaaugugg cuuguggcga gggcgacaaa gaugagacuc agagccacua cuuuuuaugc      720

aaggaaaagg cccccgacgu auucgauugg gggaguucug gaccucugug uguuucccca      780

aaauaugguu gcaacuuuaa uaacggcggg ugccaucagg acuguuucga gggaggcgau      840

gguagcuuuc ucugcgggug ucgccccggc uucagacuuc uggacgauuu ggugaccugc      900

gcgucgagga auccuuguuc uuccucacca ugccggggag gcgccacaug ugcacuaggg      960

ccccacggaa agaacuauac uugccgcugu ccgcaggguu accaacugga caguagccag     1020

cucgauugcg ucgacgugga cgaaugucag gauuccccuu gcgcucaaga gugcgugaau     1080

acccccggcg gguuucgaug ugaaugcugg gucggauaug agccaggcgg uccuggggag     1140

ggcgccuguc aggacguuga ugaaugcgcu cugggaagau cucccugugc ccagggcugc     1200

acaaacaccg acgggagcuu ccacuguuca ugcgaggaag gauacgugcu ugccggugag     1260

gauggcacgc agugucaaga cguagaugaa ugcguggggc caggaggccc ccugugugac     1320

aguuugugcu ucaauacuca ggguuccuuu cauugcgggu gucucccugg cuggguccug     1380

gcaccaaacg gagugagcug cacaaugggc ccgguuucuu uagggccccc uucaggacca     1440

cccgaugagg aggacaaagg cgaaaaggag gguaguaccg ugccuagggc ugcgacugca     1500

agcccaacac gggggcccga aggaaccccg aaagccacgc cuaccacauc ccguccaucu     1560

cugucgagcg augcucccau cacuuccgcc ccucuaaaga ugcucgcacc cucaggcagu     1620

ucuggugucu ggcgcgagcc aagcauucac caugccaccg cugccuccgg cccucaggaa     1680

cccgcagggg gagacucaag cguggcgaca cagaacaaug acggcacuga ugggcaaaaa     1740

cugcuuuugu ucuacauccu gggaaccgua guugcuauuc uccugcuucu ggccuuggca     1800

cucggccugu uaguguauag aaagaggcgg gccaagcgag aggagaaaaa ggagaaaaag     1860

ccacagaacg cugccgacuc uuacuccugg gucccggaac gcgcagaaag uagagcuaug     1920

gagaaucagu auagcccuac acccgguacc gauuguuga                            1959


<210>  8036
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8036
auggccacca gcaugggccu gcugcugcug cugcugcugc ugcugaccca gcccggcgcc       60

ggcaccggcg ccgacaccga ggccguggug ugcgugggca ccgccugcua caccgcccac      120

agcggcaagc ugagcgccgc cgaggcccag aaccacugca accagaacgg cggcaaccug      180

gccaccguga agagcaagga ggaggcccag cacgugcaga gagugcuggc ccagcugcug      240

agaagagagg ccgcccugac cgccagaaug agcaaguucu ggaucggccu gcagagagag      300

aagggcaagu gccuggaccc cagccugccc cugaagggcu ucagcugggu gggcggcggc      360

gaggacaccc ccuacagcaa cuggcacaag gagcugagaa acagcugcau cagcaagaga      420

ugcgugagcc ugcugcugga ccugagccag ccccugcugc ccagcagacu gcccaagugg      480

agcgagggcc ccugcggcag ccccggcagc cccggcagca acaucgaggg cuucgugugc      540

aaguucagcu ucaagggcau gugcagaccc cuggcccugg gcggccccgg ccaggugacc      600

uacaccaccc ccuuccagac caccagcagc agccuggagg ccgugcccuu cgccagcgcc      660

gccaacgugg ccugcggcga gggcgacaag gacgagaccc agagccacua cuuccugugc      720

aaggagaagg cccccgacgu guucgacugg ggcagcagcg gcccccugug cgugagcccc      780

aaguacggcu gcaacuucaa caacggcggc ugccaccagg acugcuucga gggcggcgac      840

ggcagcuucc ugugcggcug cagacccggc uucagacugc uggacgaccu ggugaccugc      900

gccagcagaa accccugcag cagcagcccc ugcagaggcg gcgccaccug cgcccugggc      960

ccccacggca agaacuacac cugcagaugc ccccagggcu accagcugga cagcagccag     1020

cuggacugcg uggacgugga cgagugccag gacagccccu gcgcccagga gugcgugaac     1080

acccccggcg gcuucagaug cgagugcugg gugggcuacg agcccggcgg ccccggcgag     1140

ggcgccugcc aggacgugga cgagugcgcc cugggcagaa gccccugcgc ccagggcugc     1200

accaacaccg acggcagcuu ccacugcagc ugcgaggagg gcuacgugcu ggccggcgag     1260

gacggcaccc agugccagga cguggacgag ugcgugggcc ccggcggccc ccugugcgac     1320

agccugugcu ucaacaccca gggcagcuuc cacugcggcu gccugcccgg cugggugcug     1380

gcccccaacg gcgugagcug caccaugggc cccgugagcc ugggcccccc cagcggcccc     1440

cccgacgagg aggacaaggg cgagaaggag ggcagcaccg ugcccagagc cgccaccgcc     1500

agccccacca gaggccccga gggcaccccc aaggccaccc ccaccaccag cagacccagc     1560

cugagcagcg acgcccccau caccagcgcc ccccugaaga ugcuggcccc cagcggcagc     1620

agcggcgugu ggagagagcc cagcauccac cacgccaccg ccgccagcgg cccccaggag     1680

cccgccggcg gcgacagcag cguggccacc cagaacaacg acggcaccga cggccagaag     1740

cugcugcugu ucuacauccu gggcaccgug guggccaucc ugcugcugcu ggcccuggcc     1800

cugggccugc ugguguacag aaagagaaga gccaagagag aggagaagaa ggagaagaag     1860

ccccagaacg ccgccgacag cuacagcugg gugcccgaga gagccgagag cagagccaug     1920

gagaaccagu acagccccac ccccggcacc gacugcuga                            1959


<210>  8037
<211>  1959
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C1qR__Homo_sapiens__CAC82720

<400>  8037
auggccacca gcaugggccu gcuccugcuu cugcuccugc uucugacaca gcccggggcu       60

ggaacgggcg ccgacaccga ggcggugguc ugcguuggga cagcuuguua caccgcccac      120

uccggaaagc ucucugccgc ugaagcccaa aaccauugca aucagaacgg cgggaaucug      180

gcuacaguga aaagcaagga ggaagcccag cacgugcaga gaguccuggc gcaacuccug      240

cggcgcgagg ccgcucuuac cgccagaaug uccaaauucu ggaucggacu gcagcgggaa      300

aagggcaaau gucucgaucc uucucugccg cuuaagggcu uuagcugggu gggaggaggc      360

gaggacacac ccuauuccaa cuggcauaag gagcugcgca auucuugcau uagcaaaaga      420

uguguuuccc uccugcugga ucucagccag ccucugcuuc ccucucggcu gccuaagugg      480

uccgaagggc ccugcggaag cccuggcucu ccggggucca acaucgaggg auucgugugu      540

aaauuuagcu ucaagggcau gugccgcccc cucgcucugg gcgggccugg acaggucacc      600

uacacgaccc ccuuucaaac aaccucuucc agccuugaag ccgugccuuu cgcguccgcc      660

gcuaauguug ccuguggcga gggggacaaa gaugagacac agucucacua uuuucugugc      720

aaggaaaagg cucccgacgu guucgauugg ggaagcuccg gcccgcucug ugucagcccu      780

aaauacgggu gcaacuuuaa uaacggaggc ugccaucagg acuguuucga gggcggggau      840

ggaucuuuuc ugugcggcug uagacccggg uuccggcugc ucgacgaucu ggugaccugc      900

gccucccgca auccuuguag cucuagcccc ugcagaggag gcgccacgug ugcucuuggg      960

ccccacggca agaacuauac augccggugu ccucagggau accaacugga cuccucucag     1020

cucgauugcg uggacgucga cgaaugucag gauagcccgu gcgcgcaaga gugcguuaau     1080

acccccggcg gguuucgcug ugaaugcugg gugggauaug agccuggcgg gcccggagag     1140

ggcgccuguc aggacgugga ugaaugcgcu cuggggagau ccccuugugc ccagggcugc     1200

acaaacaccg acgggagcuu ccacuguucu ugcgaggaag gcuacguccu ugccggggag     1260

gauggaaccc agugucaaga cguggaugaa ugcguuggcc ccgggggacc gcugugugac     1320

ucccucugcu ucaauacaca gggcagcuuu cauugcgggu gucugccugg cugggugcug     1380

gcucccaacg gagucucuug cacgaugggc ccuguguccc ucgggccccc uagcggaccc     1440

ccggaugagg aggacaaagg cgaaaaggag ggguccaccg uuccucgggc cgcgacagcu     1500

ucucccaccc gcggacccga aggcacaccu aaagccaccc cgacgacaag cagacccucc     1560

cugucuagcg augccccuau uaccuccgcu ccccuuaaga ugcuggcccc uagcgggucu     1620

uccggcgugu ggcgggagcc cagcauccac caugcuaccg ccgcgucugg accucaggaa     1680

cccgccggcg gggacuccag cgucgcuaca cagaacaaug acggaaccga uggccaaaaa     1740

cuccugcugu ucuacauucu ugggacagug gucgccaucc uccugcugcu cgcucuggcc     1800

cuuggacugc ucguguauag aaagcgccgg gcgaagagag aggagaaaaa ggagaaaaag     1860

ccgcagaacg ccgcugacuc uuacagcugg guuccugaac gcgccgaauc ccgggcuaug     1920

gagaaucagu auagccccac gccuggcacc gauuguuga                            1959


<210>  8038
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1s__Homo_sapiens__P09871

<400>  8038

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                165                 170                 175     


Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
            180                 185                 190         


Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
        195                 200                 205             


Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
    210                 215                 220                 


Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
225                 230                 235                 240 


Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                245                 250                 255     


Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
            260                 265                 270         


Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
        275                 280                 285             


Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
    290                 295                 300                 


Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
305                 310                 315                 320 


Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                325                 330                 335     


Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
            340                 345                 350         


Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
        355                 360                 365             


Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
    370                 375                 380                 


Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
385                 390                 395                 400 


Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                405                 410                 415     


Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
            420                 425                 430         


Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
        435                 440                 445             


Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
    450                 455                 460                 


Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
465                 470                 475                 480 


Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                485                 490                 495     


Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
            500                 505                 510         


Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
        515                 520                 525             


Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
    530                 535                 540                 


Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
545                 550                 555                 560 


Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                565                 570                 575     


Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
            580                 585                 590         


Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
        595                 600                 605             


Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
    610                 615                 620                 


Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
625                 630                 635                 640 


Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                645                 650                 655     


Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
            660                 665                 670         


Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680                 685             






<210>  8039
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8039
auguggugca uuguccuguu uucacuuuug gcauggguuu augcugagcc uaccauguau       60

ggggagaucc uguccccuaa cuauccucag gcauauccca gugagguaga gaaaucuugg      120

gacauagaag uuccugaagg guaugggauu caccucuacu ucacccaucu ggacauugag      180

cugucagaga acugugcgua ugacucagug cagauaaucu caggagacac ugaagaaggg      240

aggcucugug gacagaggag caguaacaau ccccacucuc caauugugga agaguuccaa      300

gucccauaca acaaacucca ggugaucuuu aagucagacu uuuccaauga agagcguuuu      360

acgggguuug cugcauacua uguugccaca gacauaaaug aaugcacaga uuuuguagau      420

gucccuugua gccacuucug caacaauuuc auuggugguu acuucugcuc cugccccccg      480

gaauauuucc uccaugauga caugaagaau ugcggaguua auugcagugg ggauguauuc      540

acugcacuga uuggggagau ugcaaguccc aauuauccca aaccauaucc agagaacuca      600

aggugugaau accagauccg guuggagaaa ggguuccaag ugguggugac cuugcggaga      660

gaagauuuug auguggaagc agcugacuca gcgggaaacu gccuugacag uuuaguuuuu      720

guugcaggag aucggcaauu ugguccuuac uguggucaug gauucccugg gccucuaaau      780

auugaaacca agaguaaugc ucuugauauc aucuuccaaa cugaucuaac agggcaaaaa      840

aagggcugga aacuucgcua ucauggagau ccaaugcccu gcccuaagga agacacuccc      900

aauucuguuu gggagccugc gaaggcaaaa uaugucuuua gagauguggu gcagauaacc      960

ugucuggaug gguuugaagu uguggaggga cguguuggug caacaucuuu cuauucgacu     1020

ugucaaagca auggaaagug gaguaauucc aaacugaaau gucaaccugu ggacuguggc     1080

auuccugaau ccauugagaa ugguaaaguu gaagacccag agagcacuuu guuugguucu     1140

gucauccgcu acacuuguga ggagccauau uacuacaugg aaaauggagg agguggggag     1200

uaucacugug cugguaacgg gagcugggug aaugaggugc ugggcccgga gcugccgaaa     1260

uguguuccag ucuguggagu ccccagagaa cccuuugaag aaaaacagag gauaauugga     1320

ggauccgaug cagauauuaa aaacuucccc uggcaagucu ucuuugacaa cccaugggcu     1380

gguggagcgc ucauuaauga guacugggug cugacggcug cucauguugu ggagggaaac     1440

agggagccaa caauguaugu uggguccacc ucagugcaga ccucacggcu ggcaaaaucc     1500

aagaugcuca cuccugagca uguguuuauu cauccgggau ggaagcugcu ggaaguccca     1560

gaaggacgaa ccaauuuuga uaaugacauu gcacuggugc ggcugaaaga cccagugaaa     1620

augggaccca ccgucucucc caucugccua ccaggcaccu cuuccgacua caaccucaug     1680

gauggggacc ugggacugau cucaggcugg ggccgaacag agaagagaga ucgugcuguu     1740

cgccucaagg cggcaagguu accuguagcu ccuuuaagaa aaugcaaaga agugaaagug     1800

gagaaaccca cagcagaugc agaggccuau guuuucacuc cuaacaugau cugugcugga     1860

ggagagaagg gcauggauag cuguaaaggg gacaguggug gggccuuugc uguacaggau     1920

cccaaugaca agaccaaauu cuacgcagcu ggccuggugu ccugggggcc ccaguguggg     1980

accuaugggc ucuacacacg gguaaagaac uauguugacu ggauaaugaa gacuaugcag     2040

gaaaauagca ccccccguga ggacuaa                                         2067


<210>  8040
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8040
auguggugca ucgugcuguu cagccuccug gccugggucu acgccgagcc caccauguac       60

ggcgagaucc uguccccgaa cuacccccag gcguacccca gcgaggugga gaaguccugg      120

gacaucgagg ugcccgaggg guacggcauc caccucuacu ucacccaccu ggacaucgag      180

cugagcgaga acugcgccua cgacuccguc cagaucauca gcggggacac ggaggagggc      240

cgccucugcg ggcagcgguc cagcaacaac ccgcacuccc ccaucgugga ggaguuccag      300

gugcccuaca acaagcugca ggucaucuuc aagagcgacu ucuccaacga ggagcgcuuc      360

accggcuucg ccgccuacua cguggccacc gacaucaacg agugcaccga cuucguggac      420

guccccugca gccacuucug caacaacuuc aucggcgggu acuucugcuc cugcccgccc      480

gaguacuucc ugcacgacga caugaagaac ugcggcguga acugcagcgg ggacguguuc      540

acggcgcuca ucggcgagau cgccuccccc aacuacccca agccguaccc cgagaacagc      600

cggugcgagu accagauccg ccuggagaag ggguuccagg ucguggugac ccugcggcgc      660

gaggacuucg acgucgaggc cgccgacucc gcgggcaacu gccucgacag ccugguguuc      720

guggccggcg accggcaguu cgggcccuac ugcggccacg gguuccccgg cccgcugaac      780

aucgagacca aguccaacgc ccucgacauc aucuuccaga ccgaccugac gggccagaag      840

aaggggugga agcugcgcua ccacggcgac cccaugcccu gccccaagga ggacaccccg      900

aacagcgucu gggagcccgc caaggccaag uacguguucc gggacguggu ccagaucacc      960

ugccucgacg gguucgaggu gguggagggc cgcgucgggg cgaccagcuu cuacuccacg     1020

ugccagagca acggcaagug guccaacagc aagcugaagu gccagcccgu ggacugcggc     1080

auccccgagu ccaucgagaa cgggaagguc gaggacccgg agagcacccu guucggcucc     1140

gugauccggu acaccugcga ggagcccuac uacuacaugg agaacggggg cgggggcgag     1200

uaccacugcg ccggcaacgg gagcugggug aacgaggucc ucggccccga gcugcccaag     1260

ugcgugccgg ugugcggggu cccccgcgag cccuucgagg agaagcagcg gaucaucggc     1320

ggguccgacg ccgacaucaa gaacuucccg uggcaggugu ucuucgacaa ccccugggcc     1380

ggcggcgccc ugaucaacga guacugggug cucaccgcgg cccacgucgu ggaggggaac     1440

cgcgagccca cgauguacgu gggcagcacc uccguccaga ccagccggcu ggccaagucc     1500

aagaugcuga cccccgagca cguguucauc cacccggggu ggaagcuccu ggaggugccc     1560

gagggccgca cgaacuucga caacgacauc gcccuggucc ggcucaagga ccccgugaag     1620

augggcccca ccgugagccc gaucugccug cccgggaccu ccagcgacua caaccugaug     1680

gacggcgacc ucgggcugau cuccggcugg gggcgcaccg agaagcggga ccgcgccguc     1740

cggcugaagg cggcccgccu ccccguggcc ccccugcgca agugcaagga ggugaagguc     1800

gagaagccga cggccgacgc cgaggcguac guguucaccc ccaacaugau cugcgccggc     1860

ggcgagaagg ggauggacag cugcaagggc gacuccgggg gcgccuucgc cgugcaggac     1920

cccaacgaca agaccaaguu cuacgcggcc gggcugguca gcuggggccc ccagugcggc     1980

accuacgggc ucuacacgcg ggugaagaac uacguggacu ggaucaugaa gaccaugcag     2040

gagaacagca ccccgcgcga ggacuga                                         2067


<210>  8041
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8041
auguggugca ucguccucuu cucccuccuc gccugggucu acgccgagcc caccauguac       60

ggcgagaucc ucucccccaa cuacccccag gccuaccccu ccgaggucga gaaguccugg      120

gacaucgagg uccccgaggg cuacggcauc caccucuacu ucacccaccu cgacaucgag      180

cucuccgaga acugcgccua cgacuccguc cagaucaucu ccggcgacac cgaggagggc      240

cgccucugcg gccagcgcuc cuccaacaac ccccacuccc ccaucgucga ggaguuccag      300

guccccuaca acaagcucca ggucaucuuc aaguccgacu ucuccaacga ggagcgcuuc      360

accggcuucg ccgccuacua cgucgccacc gacaucaacg agugcaccga cuucgucgac      420

guccccugcu cccacuucug caacaacuuc aucggcggcu acuucugcuc cugccccccc      480

gaguacuucc uccacgacga caugaagaac ugcggcguca acugcuccgg cgacgucuuc      540

accgcccuca ucggcgagau cgccuccccc aacuacccca agcccuaccc cgagaacucc      600

cgcugcgagu accagauccg ccucgagaag ggcuuccagg ucgucgucac ccuccgccgc      660

gaggacuucg acgucgaggc cgccgacucc gccggcaacu gccucgacuc ccucgucuuc      720

gucgccggcg accgccaguu cggccccuac ugcggccacg gcuuccccgg cccccucaac      780

aucgagacca aguccaacgc ccucgacauc aucuuccaga ccgaccucac cggccagaag      840

aagggcugga agcuccgcua ccacggcgac cccaugcccu gccccaagga ggacaccccc      900

aacuccgucu gggagcccgc caaggccaag uacgucuucc gcgacgucgu ccagaucacc      960

ugccucgacg gcuucgaggu cgucgagggc cgcgucggcg ccaccuccuu cuacuccacc     1020

ugccagucca acggcaagug guccaacucc aagcucaagu gccagcccgu cgacugcggc     1080

auccccgagu ccaucgagaa cggcaagguc gaggaccccg aguccacccu cuucggcucc     1140

gucauccgcu acaccugcga ggagcccuac uacuacaugg agaacggcgg cggcggcgag     1200

uaccacugcg ccggcaacgg cuccuggguc aacgaggucc ucggccccga gcuccccaag     1260

ugcguccccg ucugcggcgu cccccgcgag cccuucgagg agaagcagcg caucaucggc     1320

ggcuccgacg ccgacaucaa gaacuucccc uggcaggucu ucuucgacaa ccccugggcc     1380

ggcggcgccc ucaucaacga guacuggguc cucaccgccg cccacgucgu cgagggcaac     1440

cgcgagccca ccauguacgu cggcuccacc uccguccaga ccucccgccu cgccaagucc     1500

aagaugcuca cccccgagca cgucuucauc caccccggcu ggaagcuccu cgaggucccc     1560

gagggccgca ccaacuucga caacgacauc gcccucgucc gccucaagga ccccgucaag     1620

augggcccca ccgucucccc caucugccuc cccggcaccu ccuccgacua caaccucaug     1680

gacggcgacc ucggccucau cuccggcugg ggccgcaccg agaagcgcga ccgcgccguc     1740

cgccucaagg ccgcccgccu ccccgucgcc ccccuccgca agugcaagga ggucaagguc     1800

gagaagccca ccgccgacgc cgaggccuac gucuucaccc ccaacaugau cugcgccggc     1860

ggcgagaagg gcauggacuc cugcaagggc gacuccggcg gcgccuucgc cguccaggac     1920

cccaacgaca agaccaaguu cuacgccgcc ggccucgucu ccuggggccc ccagugcggc     1980

accuacggcc ucuacacccg cgucaagaac uacgucgacu ggaucaugaa gaccaugcag     2040

gagaacucca ccccccgcga ggacuga                                         2067


<210>  8042
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8042
auguggugca ucgugcuguu cagccuccuu gccugggucu acgcugagcc caccauguau       60

ggcgaaauuc uguccccuaa cuacccacag gcauauccgu cugagguuga aaagucaugg      120

gacauagagg ugcccgaagg guacggaauc cacuuguauu uuacacauuu agauauugag      180

cugagugaga auugugccua cgacagcgua caaaucauuu ccggugauac ugaagagggc      240

agacuaugcg ggcagagguc uucgaacaau ccucacucac caaucgugga agaguuccag      300

guccccuaua acaaacucca ggugauauuu aagagcgacu ucaguaauga ggaacgguuu      360

acgggauucg cggcuuacua cguugccacc gauaucaacg aguguacaga cuuuguggau      420

gucccuugcu cccauuucug uaauaacuuu auuggcgguu auuucugcuc uuguccaccc      480

gaauacuuuc ugcacgacga uaugaaaaau ugcgggguga acuguagcgg agacguauuc      540

acugcacuua ucggcgagau ugccuccccu aauuauccaa agccguaccc cgaaaacuca      600

cgcugcgagu aucaaauccg acuggagaaa ggcuuucagg uuguggucac cuugcguaga      660

gaagauuucg acguggaggc ugcagauagu gccgggaauu gucucgacag ccugguguuc      720

gucgcuggag acaggcaguu ugguccuuac ugcggccaug gguucccagg accccugaac      780

auagaaacaa agucuaaugc ccucgauauu aucuuucaga ccgacuuaac uggccaaaag      840

aaagguugga agcugcggua ucacggggau ccuaugccau gccccaaaga ggacacaccg      900

aacuccguuu gggaaccugc gaaggcaaaa uacguguucc gcgauguagu gcagauuacc      960

ugucuugacg gauuugaggu cguggagggc agaguuggcg ccacgucauu cuacagcacu     1020

ugccagagua acgggaagug gucuaauucc aaguugaaau gucagcccgu ggauugcgga     1080

aucccagaaa gcaucgagaa cgguaagguc gaagacccug agucgacccu guuuggcucu     1140

gugauuaggu auacauguga ggaacccuac uauuacaugg agaauggggg aggcggugaa     1200

uaucacugcg cugggaacgg cuccugggua aaugagguuc uaggaccaga acuccccaaa     1260

ugugugccug ucugcggcgu gccacgggag ccguucgagg aaaagcaacg cauaaucggg     1320

ggaucagaug ccgacauuaa aaacuuuccc uggcaggucu ucuuugauaa uccuugggcu     1380

gguggcgcac ugaucaacga guacugggug cuuacugccg cgcauguugu ggaagggaau     1440

cgagagccaa ccauguaugu aggaaguaca agcguccaga ccuccagacu ggccaagucu     1500

aaaauguuga cgcccgaaca cguguucaua cauccuggcu ggaagcuccu ggagguucca     1560

gaggguagga cuaacuuuga caaugacauu gcauuagugc ggcugaagga ucccgucaaa     1620

auggggccga cagugagccc uaucugucuc ccaggcaccu caagugacua caaccuuaug     1680

gauggagacc ugggcuugau cuccgggugg ggacguacug aaaagcgcga uagagcugua     1740

aggcuaaaag ccgcucggcu gcccguggcc ccucuccgaa agugcaaaga gguuaagguc     1800

gaaaagccca cagcagacgc cgaggcuuac guguucaccc caaauaugau uugugcgggu     1860

ggcgaaaaag ggauggauag cugcaaggga gacucuggcg gugcauucgc cgugcaagau     1920

ccuaacgaca aaacgaaguu uuaugcugcc gggcuggucu cauggggccc ccagugcgga     1980

accuacggcc uuuauacacg cguuaaaaau uacguggauu ggaucaugaa gacuaugcag     2040

gagaacagua ccccaagaga ggacuga                                         2067


<210>  8043
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8043
auguggugca ucgugcuguu cagccugcug gccugggugu acgccgagcc caccauguac       60

ggcgagaucc ugagccccaa cuacccccag gccuacccca gcgaggugga gaagagcugg      120

gacaucgagg ugcccgaggg cuacggcauc caccuguacu ucacccaccu ggacaucgag      180

cugagcgaga acugcgccua cgacagcgug cagaucauca gcggcgacac cgaggagggc      240

agacugugcg gccagagaag cagcaacaac ccccacagcc ccaucgugga ggaguuccag      300

gugcccuaca acaagcugca ggugaucuuc aagagcgacu ucagcaacga ggagagauuc      360

accggcuucg ccgccuacua cguggccacc gacaucaacg agugcaccga cuucguggac      420

gugcccugca gccacuucug caacaacuuc aucggcggcu acuucugcag cugccccccc      480

gaguacuucc ugcacgacga caugaagaac ugcggcguga acugcagcgg cgacguguuc      540

accgcccuga ucggcgagau cgccagcccc aacuacccca agcccuaccc cgagaacagc      600

agaugcgagu accagaucag acuggagaag ggcuuccagg ugguggugac ccugagaaga      660

gaggacuucg acguggaggc cgccgacagc gccggcaacu gccuggacag ccugguguuc      720

guggccggcg acagacaguu cggccccuac ugcggccacg gcuuccccgg cccccugaac      780

aucgagacca agagcaacgc ccuggacauc aucuuccaga ccgaccugac cggccagaag      840

aagggcugga agcugagaua ccacggcgac cccaugcccu gccccaagga ggacaccccc      900

aacagcgugu gggagcccgc caaggccaag uacguguuca gagacguggu gcagaucacc      960

ugccuggacg gcuucgaggu gguggagggc agagugggcg ccaccagcuu cuacagcacc     1020

ugccagagca acggcaagug gagcaacagc aagcugaagu gccagcccgu ggacugcggc     1080

auccccgaga gcaucgagaa cggcaaggug gaggaccccg agagcacccu guucggcagc     1140

gugaucagau acaccugcga ggagcccuac uacuacaugg agaacggcgg cggcggcgag     1200

uaccacugcg ccggcaacgg cagcugggug aacgaggugc ugggccccga gcugcccaag     1260

ugcgugcccg ugugcggcgu gcccagagag cccuucgagg agaagcagag aaucaucggc     1320

ggcagcgacg ccgacaucaa gaacuucccc uggcaggugu ucuucgacaa ccccugggcc     1380

ggcggcgccc ugaucaacga guacugggug cugaccgccg cccacguggu ggagggcaac     1440

agagagccca ccauguacgu gggcagcacc agcgugcaga ccagcagacu ggccaagagc     1500

aagaugcuga cccccgagca cguguucauc caccccggcu ggaagcugcu ggaggugccc     1560

gagggcagaa ccaacuucga caacgacauc gcccugguga gacugaagga ccccgugaag     1620

augggcccca ccgugagccc caucugccug cccggcacca gcagcgacua caaccugaug     1680

gacggcgacc ugggccugau cagcggcugg ggcagaaccg agaagagaga cagagccgug     1740

agacugaagg ccgccagacu gcccguggcc ccccugagaa agugcaagga ggugaaggug     1800

gagaagccca ccgccgacgc cgaggccuac guguucaccc ccaacaugau cugcgccggc     1860

ggcgagaagg gcauggacag cugcaagggc gacagcggcg gcgccuucgc cgugcaggac     1920

cccaacgaca agaccaaguu cuacgccgcc ggccugguga gcuggggccc ccagugcggc     1980

accuacggcc uguacaccag agugaagaac uacguggacu ggaucaugaa gaccaugcag     2040

gagaacagca cccccagaga ggacuga                                         2067


<210>  8044
<211>  2067
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C1s__Homo_sapiens__AAA51852

<400>  8044
auguggugca ucgugcuguu cagccuccug gccugggucu acgcugagcc caccauguau       60

ggcgaaauuc uuuccccuaa cuacccgcag gccuaucccu cugagguuga aaagagcugg      120

gacaucgagg ugccugaagg guacggcauu caccuguauu uuacacaucu cgauaucgag      180

cuguccgaga auugugcgua cgacucugug caaauuauca gcggagauac ggaagagggg      240

agacuuugcg gacagcgguc cucuaacaau ccccacagcc cuaucgucga agaguuccag      300

gugcccuaua acaaacugca gguuauuuuu aaguccgacu ucagcaauga ggaacgcuuu      360

accggcuucg cugccuacua cguggccaca gauaucaacg aguguaccga cuuugucgau      420

gugccuugcu cucauuucug uaauaacuuu auugggggau auuucugcuc cuguccgccc      480

gaauacuuuc uccacgacga uaugaaaaau ugcggcguua acuguagcgg cgacguguuc      540

acagcucuga ucggggagau ugccucuccu aauuauccca agccuuaccc cgaaaacucc      600

agaugcgagu aucaaauccg gcuggagaaa ggauuucagg ucguggugac ccuccgcaga      660

gaagauuucg acgucgaggc ugccgauagc gcgggcaauu gucuggacuc ucuuguuuuc      720

guggccgggg accggcaguu uggaccguac ugcggccaug gguucccugg accccugaac      780

auugaaacaa aguccaaugc ucucgauauc aucuuucaga ccgaccugac gggccaaaag      840

aaaggcugga aacuucgcua ucacggggau ccuaugcccu gccccaagga ggacaccccu      900

aacagcgugu gggaaccggc caaggcuaaa uacgucuuca gagauguggu ucagauuaca      960

ugucuggacg gauuugaggu ggucgagggc cggguggggg ccaccuccuu cuacucuaca     1020

ugccagagca acggaaagug guccaauagc aagcucaaau gucagcccgu ugauugcggc     1080

aucccugaau cuauugagaa cgggaaggug gaagaccccg aguccacccu guuuggaagc     1140

gucauccgcu auacguguga ggaaccuuac uauuacaugg agaauggcgg cgggggagaa     1200

uaucacugcg cgggcaacgg gucuugggug aaugaggucc ugggacccga acucccgaaa     1260

ugugugccug uuugcggcgu gcccagagag ccuuucgagg aaaagcaacg gauuaucggg     1320

ggcagcgaug ccgacaucaa aaacuuuccc uggcaggucu ucuuugauaa uccuugggcu     1380

ggaggcgccc ugauuaacga guacugggug cuuacagcug cccauguugu ggaagggaau     1440

cgcgagccca ccauguaugu cggauccaca ucugugcaga ccagcagacu ggccaagucc     1500

aaaaugcuca ccccggaaca cguguucauc cauccuggcu ggaagcugcu ugagguuccc     1560

gaggggcgga caaacuuuga caaugacauu gcucuggucc gccucaagga ucccgugaaa     1620

augggaccua cggugagccc gaucugucug cccggcaccu cuuccgacua caaccugaug     1680

gauggggacc ucggccugau uagcggaugg ggcagaacag aaaagcggga uagagcgguc     1740

cgccuuaaag ccgcucggcu gccuguggcg ccccucagaa agugcaaaga gguuaaggug     1800

gaaaagccua ccgccgacgc ugaggccuac gucuucacac ccaauaugau cugugccggg     1860

ggagaaaaag gcauggauuc uugcaagggg gacuccggag gcgcuuucgc cgugcaagau     1920

ccuaacgaca aaaccaaguu uuaugccgcu gggcugguua gcuggggccc ccagugcgga     1980

acguacggcc uuuauacacg cgugaaaaau uacgucgauu ggaucaugaa gaccaugcag     2040

gagaacucca ccccgcggga ggacuga                                         2067


<210>  8045
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C4bp__Homo_sapiens__P04003

<400>  8045

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 
145                 150                 155                 160 


Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 
                165                 170                 175     


Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 
            180                 185                 190         


Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser 
        195                 200                 205             


Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile 
    210                 215                 220                 


Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg 
225                 230                 235                 240 


Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile 
                245                 250                 255     


Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val 
            260                 265                 270         


Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 
        275                 280                 285             


Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 
    290                 295                 300                 


Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 
305                 310                 315                 320 


Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr 
                325                 330                 335     


Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu 
            340                 345                 350         


Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro 
        355                 360                 365             


Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala 
    370                 375                 380                 


Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 
385                 390                 395                 400 


Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 
                405                 410                 415     


Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 
            420                 425                 430         


Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu 
        435                 440                 445             


Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala 
    450                 455                 460                 


Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys 
465                 470                 475                 480 


Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val 
                485                 490                 495     


Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp 
            500                 505                 510         


Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 
        515                 520                 525             


Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 
    530                 535                 540                 


Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
545                 550                 555                 560 


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
                565                 570                 575     


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
            580                 585                 590         


Leu Asp Lys Glu Leu 
        595         


<210>  8046
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8046
augcaccccc caaaaacucc aucuggggcu cuucauagaa aaaggaaaau ggcagccugg       60

cccuucucca ggcuguggaa agucucugau ccaauucucu uccaaaugac cuugaucgcu      120

gcucuguugc cugcuguucu uggcaauugu gguccuccac ccacuuuauc auuugcugcc      180

ccgauggaua uuacguugac ugagacacgc uucaaaacug gaacuacucu gaaauacacc      240

ugccucccug gcuacgucag aucccauuca acucagacgc uuaccuguaa uucugauggc      300

gaaugggugu auaacaccuu cuguaucuac aaacgaugca gacacccagg agaguuacgu      360

aaugggcaag uagagauuaa gacagauuua ucuuuuggau cacaaauaga auucagcugu      420

ucagaaggau uuuucuuaau uggcucaacc acuagucguu gugaagucca agauagagga      480

guuggcugga gucauccucu cccacaaugu gaaauuguca aguguaagcc uccuccagac      540

aucaggaaug gaaggcacag cggugaagaa aauuucuacg cauacggcuu uucugucacc      600

uacagcugug acccccgcuu cucacucuug ggccaugccu ccauuucuug cacuguggag      660

aaugaaacaa uaggcguuug gagaccaagc ccuccuaccu gugaaaaaau caccugucgc      720

aagccagaug uuucacaugg ggaaaugguc ucuggauuug gacccaucua uaauuacaaa      780

gacacuauug uguuuaagug ccaaaaaggu uuuguucuca gaggcagcag uguaauucau      840

ugugaugcug auagcaaaug gaauccuucu ccuccugcuu gugagcccaa uaguuguauu      900

aauuuaccag acauuccaca ugcuuccugg gaaacauauc cuaggccgac aaaagaggau      960

guguauguug uugggacugu guuaagguac cgcugucauc cuggcuacaa acccacuaca     1020

gaugagccua cgacugugau uugucagaaa aauuugagau ggaccccaua ccaaggaugu     1080

gaggcguuau guugcccuga accaaagcua aauaauggug aaaucacuca acacaggaaa     1140

agucguccug ccaaucacug uguuuauuuc uauggagaug agauuucauu uucaugucau     1200

gagaccagua gguuuucagc uauaugccaa ggagauggca cguggagucc ccgaacacca     1260

ucauguggag acauuugcaa uuuuccuccu aaaauugccc augggcauua uaaacaaucu     1320

aguucauaca gcuuuuucaa agaagagauu auauaugaau gugauaaagg cuacauucug     1380

gucggacagg cgaaacucuc cugcaguuau ucacacuggu cagcuccagc cccucaaugu     1440

aaagcucugu gucggaaacc agaauuagug aauggaaggu ugucugugga uaaggaucag     1500

uauguugagc cugaaaaugu caccauccaa ugugauucug gcuauggugu gguugguccc     1560

caaaguauca cuugcucugg gaacagaacc ugguacccag aggugcccaa gugugagugg     1620

gagacccccg aaggcuguga acaagugcuc acaggcaaaa gacucaugca gugucuccca     1680

aacccagagg augugaaaau ggcccuggag guauauaagc ugucucugga aauugaacaa     1740

cuggaacuac agagagacag cgcaagacaa uccacuuugg auaaagaacu auaa           1794


<210>  8047
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8047
augcacccgc ccaagacccc cagcggcgcc cugcaccgca agcggaagau ggccgcgugg       60

cccuucuccc gccucuggaa ggugagcgac cccauccugu uccagaugac ccugaucgcc      120

gcccuccugc cggccguccu ggggaacugc ggcccgccgc ccacgcucuc cuucgccgcg      180

cccauggaca ucacccugac cgagacccgg uucaagacgg ggaccacccu gaaguacacg      240

ugccuccccg gcuacgugcg cagccacucc acgcagaccc ugaccugcaa cagcgacggg      300

gagugggugu acaacaccuu cugcaucuac aagcggugcc gccaccccgg cgagcugcgg      360

aacggccagg ucgagaucaa gacggaccuc uccuucggga gccagaucga guucuccugc      420

agcgagggcu ucuuccugau cggguccacc accagccgcu gcgaggugca ggaccggggc      480

gugggguggu cccacccccu gccccagugc gagaucguca agugcaagcc cccgcccgac      540

auccgcaacg gccggcacag cggcgaggag aacuucuacg ccuacggguu cuccgugacc      600

uacagcugcg acccccgcuu cucccuccug ggccacgcca gcaucuccug caccguggag      660

aacgagacca ucggggucug gcggcccagc ccgcccacgu gcgagaagau cacgugccgc      720

aagcccgacg ugagccacgg cgagauggug uccggcuucg ggcccaucua caacuacaag      780

gacaccaucg ucuucaagug ccagaagggc uucgugcugc gggggagcuc cgugauccac      840

ugcgacgccg acagcaagug gaaccccagc ccgcccgcgu gcgagcccaa cuccugcauc      900

aaccuccccg acauccccca cgccuccugg gagaccuacc cgcgccccac caaggaggac      960

gucuacgugg ugggcaccgu ccugcgguac cgcugccacc ccggguacaa gccgaccacc     1020

gacgagccca ccaccgugau cugccagaag aaccugcggu ggacgcccua ccagggcugc     1080

gaggcccucu gcugccccga gccgaagcug aacaacggcg agaucaccca gcaccgcaag     1140

agccggcccg ccaaccacug cguguacuuc uacggggacg agaucuccuu cagcugccac     1200

gagaccuccc gcuucagcgc caucugccag ggcgacggga ccuggagccc ccgcacgccc     1260

uccugcggcg acaucugcaa cuucccgccc aagaucgcgc acgggcacua caagcagucc     1320

agcuccuaca gcuucuucaa ggaggagauc aucuacgagu gcgacaaggg cuacauccug     1380

gucggccagg ccaagcucuc cugcagcuac agccacuggu ccgcccccgc gccccagugc     1440

aaggcccugu gccggaagcc ggagcuggug aacgggcgcc ucagcgugga caaggaccag     1500

uacgucgagc ccgagaacgu gaccauccag ugcgacuccg gcuacggggu cgugggcccc     1560

cagagcauca cgugcuccgg gaaccggacc ugguaccccg aggugccgaa gugcgagugg     1620

gagacccccg agggcugcga gcagguccug accggcaagc gccugaugca gugccucccc     1680

aaccccgagg acgugaagau ggcccuggag guguacaagc ugagccucga gaucgagcag     1740

cuggagcugc agcgggacuc cgcccgccag agcacccucg acaaggagcu guga           1794


<210>  8048
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8048
augcaccccc ccaagacccc cuccggcgcc cuccaccgca agcgcaagau ggccgccugg       60

cccuucuccc gccucuggaa ggucuccgac cccauccucu uccagaugac ccucaucgcc      120

gcccuccucc ccgccguccu cggcaacugc ggcccccccc ccacccucuc cuucgccgcc      180

cccauggaca ucacccucac cgagacccgc uucaagaccg gcaccacccu caaguacacc      240

ugccuccccg gcuacguccg cucccacucc acccagaccc ucaccugcaa cuccgacggc      300

gagugggucu acaacaccuu cugcaucuac aagcgcugcc gccaccccgg cgagcuccgc      360

aacggccagg ucgagaucaa gaccgaccuc uccuucggcu cccagaucga guucuccugc      420

uccgagggcu ucuuccucau cggcuccacc accucccgcu gcgaggucca ggaccgcggc      480

gucggcuggu cccacccccu cccccagugc gagaucguca agugcaagcc cccccccgac      540

auccgcaacg gccgccacuc cggcgaggag aacuucuacg ccuacggcuu cuccgucacc      600

uacuccugcg acccccgcuu cucccuccuc ggccacgccu ccaucuccug caccgucgag      660

aacgagacca ucggcgucug gcgccccucc ccccccaccu gcgagaagau caccugccgc      720

aagcccgacg ucucccacgg cgagaugguc uccggcuucg gccccaucua caacuacaag      780

gacaccaucg ucuucaagug ccagaagggc uucguccucc gcggcuccuc cgucauccac      840

ugcgacgccg acuccaagug gaaccccucc ccccccgccu gcgagcccaa cuccugcauc      900

aaccuccccg acauccccca cgccuccugg gagaccuacc cccgccccac caaggaggac      960

gucuacgucg ucggcaccgu ccuccgcuac cgcugccacc ccggcuacaa gcccaccacc     1020

gacgagccca ccaccgucau cugccagaag aaccuccgcu ggacccccua ccagggcugc     1080

gaggcccucu gcugccccga gcccaagcuc aacaacggcg agaucaccca gcaccgcaag     1140

ucccgccccg ccaaccacug cgucuacuuc uacggcgacg agaucuccuu cuccugccac     1200

gagaccuccc gcuucuccgc caucugccag ggcgacggca ccuggucccc ccgcaccccc     1260

uccugcggcg acaucugcaa cuuccccccc aagaucgccc acggccacua caagcagucc     1320

uccuccuacu ccuucuucaa ggaggagauc aucuacgagu gcgacaaggg cuacauccuc     1380

gucggccagg ccaagcucuc cugcuccuac ucccacuggu ccgcccccgc cccccagugc     1440

aaggcccucu gccgcaagcc cgagcucguc aacggccgcc ucuccgucga caaggaccag     1500

uacgucgagc ccgagaacgu caccauccag ugcgacuccg gcuacggcgu cgucggcccc     1560

caguccauca ccugcuccgg caaccgcacc ugguaccccg agguccccaa gugcgagugg     1620

gagacccccg agggcugcga gcagguccuc accggcaagc gccucaugca gugccucccc     1680

aaccccgagg acgucaagau ggcccucgag gucuacaagc ucucccucga gaucgagcag     1740

cucgagcucc agcgcgacuc cgcccgccag uccacccucg acaaggagcu cuga           1794


<210>  8049
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8049
augcacccuc cuaagacccc aagcggcgcc cugcauagaa aaaggaagau ggcugcaugg       60

ccguucuccc ggcucuggaa agugucugac cccauccuuu uucagaugac acugauugcc      120

gcguuguuac cugcuguccu ggggaacugc ggaccacccc cuacucuauc auucgccgca      180

ccaauggaua uaacgcucac cgagacacgc uuuaagacug guaccacacu gaaauacacc      240

ugucuucccg gcuauguucg aagucacagc acucaaacac ugaccugcaa uuccgacggg      300

gaaugggugu acaacacguu cuguaucuau aagcguugca gacauccugg agaguugagg      360

aauggccagg uagaaauuaa gacugaucuc ucuuuugguu cgcagaucga guucucaugu      420

agcgaagggu uuuuccugau uggaaguacc acaucccggu gcgaggugca ggaccgcggc      480

gucggcuggu cucacccacu gccgcaaugu gagaucguga aaugcaagcc cccuccagau      540

auaagaaacg ggaggcauag cggagaagag aauuuuuacg ccuaugguuu cuccguuacu      600

uacucaugug acccccgguu uagucucuua ggccacgcua gcaucucuug caccguggaa      660

aacgagacaa uuggggucug gcgcccuucc ccacccaccu gugagaaaau cacgugccga      720

aagccggaug ugucacacgg agaaauggua agcggcuucg guccuauuua uaauuacaaa      780

gacacuaucg uuuuuaagug ccagaagggg uucgugcuga gaggaaguuc ugucauacau      840

ugugaugcag acuccaaaug gaaccccagc ccacccgccu gcgagcccaa uucguguauu      900

aaccuuccag auauccccca cgcuucuugg gaaacauacc cuaggccaac caaggaggac      960

guguaugugg ucggcacugu uuugcgguac cguugccauc cgggcuauaa acccacaacc     1020

gaugaaccua cgaccgugau uugucagaag aaucugcgcu ggacaccaua ccaggggugc     1080

gaggcccuau guugccccga gccuaaacuc aacaauggag aaaucacuca acacagaaag     1140

uccaggccag cgaaccacug uguauauuuc uacggugacg agaucucauu uaguugccau     1200

gaaaccagcc gguucuccgc aauuugucag ggcgacggga cauggucucc ccgaacuccg     1260

agcugcggag auauaugcaa uuuuccucca aaaaucgccc acggccauua uaagcaguca     1320

aguuccuaca gcuucuuuaa ggaggaaauu aucuacgagu gugacaaagg uuauauacug     1380

guggggcagg cuaaacuuuc uugcucauac agucacugga gcgcccccgc accucaaugu     1440

aaggcucugu gccgcaagcc cgaguugguc aacggcagac ucuccgugga uaaagaccag     1500

uauguugaac cagagaacgu gaccauucag ugugauucug gauacggcgu cguggggccu     1560

caaucgauca caugcagcgg aaauaggacc ugguaucccg aaguaccaaa gugugagugg     1620

gaaacuccgg aggguugcga gcagguucug acgggcaagc gguuaaugca gugucugccu     1680

aaccccgaag acgugaaaau ggcccucgag gucuacaaac uuucccugga aaucgagcag     1740

uuggagcuac aacgcgauuc agcgagacag aguacacugg acaaggaacu cuga           1794


<210>  8050
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8050
augcaccccc ccaagacccc cagcggcgcc cugcacagaa agagaaagau ggccgccugg       60

cccuucagca gacuguggaa ggugagcgac cccauccugu uccagaugac ccugaucgcc      120

gcccugcugc ccgccgugcu gggcaacugc ggcccccccc ccacccugag cuucgccgcc      180

cccauggaca ucacccugac cgagaccaga uucaagaccg gcaccacccu gaaguacacc      240

ugccugcccg gcuacgugag aagccacagc acccagaccc ugaccugcaa cagcgacggc      300

gagugggugu acaacaccuu cugcaucuac aagagaugca gacaccccgg cgagcugaga      360

aacggccagg uggagaucaa gaccgaccug agcuucggca gccagaucga guucagcugc      420

agcgagggcu ucuuccugau cggcagcacc accagcagau gcgaggugca ggacagaggc      480

gugggcugga gccacccccu gccccagugc gagaucguga agugcaagcc cccccccgac      540

aucagaaacg gcagacacag cggcgaggag aacuucuacg ccuacggcuu cagcgugacc      600

uacagcugcg accccagauu cagccugcug ggccacgcca gcaucagcug caccguggag      660

aacgagacca ucggcgugug gagacccagc ccccccaccu gcgagaagau caccugcaga      720

aagcccgacg ugagccacgg cgagauggug agcggcuucg gccccaucua caacuacaag      780

gacaccaucg uguucaagug ccagaagggc uucgugcuga gaggcagcag cgugauccac      840

ugcgacgccg acagcaagug gaaccccagc ccccccgccu gcgagcccaa cagcugcauc      900

aaccugcccg acauccccca cgccagcugg gagaccuacc ccagacccac caaggaggac      960

guguacgugg ugggcaccgu gcugagauac agaugccacc ccggcuacaa gcccaccacc     1020

gacgagccca ccaccgugau cugccagaag aaccugagau ggacccccua ccagggcugc     1080

gaggcccugu gcugccccga gcccaagcug aacaacggcg agaucaccca gcacagaaag     1140

agcagacccg ccaaccacug cguguacuuc uacggcgacg agaucagcuu cagcugccac     1200

gagaccagca gauucagcgc caucugccag ggcgacggca ccuggagccc cagaaccccc     1260

agcugcggcg acaucugcaa cuuccccccc aagaucgccc acggccacua caagcagagc     1320

agcagcuaca gcuucuucaa ggaggagauc aucuacgagu gcgacaaggg cuacauccug     1380

gugggccagg ccaagcugag cugcagcuac agccacugga gcgcccccgc cccccagugc     1440

aaggcccugu gcagaaagcc cgagcuggug aacggcagac ugagcgugga caaggaccag     1500

uacguggagc ccgagaacgu gaccauccag ugcgacagcg gcuacggcgu ggugggcccc     1560

cagagcauca ccugcagcgg caacagaacc ugguaccccg aggugcccaa gugcgagugg     1620

gagacccccg agggcugcga gcaggugcug accggcaaga gacugaugca gugccugccc     1680

aaccccgagg acgugaagau ggcccuggag guguacaagc ugagccugga gaucgagcag     1740

cuggagcugc agagagacag cgccagacag agcacccugg acaaggagcu guga           1794


<210>  8051
<211>  1794
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C4bp__Homo_sapiens__AAA36506

<400>  8051
augcaucccc cuaagacccc gagcggcgcc cugcacagaa aacggaagau ggcugccugg       60

cccuucuccc gccucuggaa agugucugac ccuauccugu uucagaugac acuuauugcg      120

gcucugcucc ccgccguccu ggggaacugc ggaccucccc cuacgcuuag cuucgccgcu      180

ccgauggaua ucacccugac agagaccaga uuuaagacag gcaccacacu caaauacacc      240

ugucugcccg gguauguucg gucccacucu acgcaaaccc ugacaugcaa uagcgacgga      300

gaaugggugu acaacaccuu cuguauuuau aagcgcugca gacauccugg cgagcuccgg      360

aauggacagg uggaaaucaa gacagaucug uccuuugggu cucagauuga guucagcugu      420

uccgaaggcu uuuuccuuau cggcagcacc acgucucgcu gcgaggucca ggacagaggg      480

gugggauggu cccacccccu gccucaaugu gagaucguua aaugcaagcc cccgccugau      540

auucggaacg gccgccauag cggggaagag aauuuuuacg ccuauggauu cucugugaca      600

uacuccugug accccagauu uagccuccug ggccacgcuu cuaucuccug caccgucgaa      660

aacgagacaa uuggggugug gcggccuagc ccucccaccu gugagaaaau uaccugccgc      720

aagcccgaug uuucccacgg agaaauggug ucuggcuucg gcccgaucua uaauuacaaa      780

gacacaaucg ucuuuaagug ccagaagggg uucgugcuua gaggaagcuc cgugauucau      840

ugugaugccg acagcaaaug gaaccccucu ccucccgcgu gcgagccuaa uuccuguauc      900

aaccugcccg auaucccgca cgccagcugg gaaacguacc cucggcccac caaggaggac      960

gucuauguug ugggcacagu gcuccgcuac agaugccauc cuggguauaa acccaccaca     1020

gaugaaccua ccacggucau uugucagaag aaucugcggu ggacacccua ccagggaugc     1080

gaggcucugu guugcccgga gccuaaacuc aacaauggcg aaaucaccca acacagaaag     1140

ucucgccccg ccaaccacug uguguauuuc uacggggacg agauuagcuu uuccugccau     1200

gaaaccucuc gguucagcgc uaucugucag ggagacggca cauggucccc cagaaccccu     1260

agcugcggcg auauuugcaa uuuuccgccc aaaaucgccc acgggcauua uaagcagucu     1320

uccagcuacu cuuucuuuaa ggaggaaauc auuuacgagu gugacaaagg auauauccug     1380

guuggccagg cgaaacuuuc cugcagcuac ucccacuggu cugccccugc uccccaaugu     1440

aaggcccugu gccgcaagcc ugagcucgug aacgggcggc ugagcgucga uaaagaccag     1500

uauguggaac ccgagaacgu uacaauucag ugugauuccg gauacggcgu ggucgggccu     1560

caaucuauca cgugcagcgg caauagaacc ugguaucccg aagugccgaa gugugagugg     1620

gaaacaccug agggaugcga gcagguccuu accggcaagc gccugaugca gugucucccc     1680

aacccugaag acgugaaaau ggcucuggag guuuacaagc ugucccucga aauugagcag     1740

cuggagcuuc aacgggauag cgccagacag ucuacacugg acaaagaacu cuga           1794


<210>  8052
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C6__Homo_sapiens__P13671

<400>  8052

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  8053
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8053
auggccagac gcucugucuu guacuucauc cugcugaaug cucugaucaa caagggccaa       60

gccugcuucu gugaucacua ugcauggacu caguggacca gcugcucaaa aacuugcaau      120

ucuggaaccc agagcagaca cagacaaaua guaguagaua aguacuacca ggaaaacuuu      180

ugugaacaga uuugcagcaa gcaggagacu agagaaugua acuggcaaag augccccauc      240

aacugccucc ugggagauuu uggaccaugg ucagacugug acccuuguau ugaaaaacag      300

ucuaaaguua gaucugucuu gcgucccagu caguuugggg gacagccaug cacugcgccu      360

cugguagccu uucaaccaug cauuccaucu aagcucugca aaauugaaga ggcugacugc      420

aagaauaaau uucgcuguga caguggccgc ugcauugcca gaaaguuaga augcaaugga      480

gaaaaugacu guggagacaa uucagaugaa agggacugug ggaggacaaa ggcaguaugc      540

acacggaagu auaaucccau cccuagugua caguugaugg gcaauggguu ucauuuucug      600

gcaggagagc ccagaggaga aguccuugau aacucuuuca cuggaggaau auguaaaacu      660

gucaaaagca guaggacaag uaauccauac cguguuccgg ccaaucugga aaaugucggc      720

uuugagguac aaacugcaga agaugacuug aaaacagauu ucuacaagga uuuaacuucu      780

cuuggacaca augaaaauca acaaggcuca uucucaaguc agggggggag cucuuucagu      840

guaccaauuu uuuauuccuc aaagagaagu gaaaauauca accauaauuc ugccuucaaa      900

caagccauuc aagccucuca caaaaaggau ucuaguuuua uuaggaucca uaaagugaug      960

aaagucuuaa acuucacaac gaaagcuaaa gaucugcacc uuucugaugu cuuuuugaaa     1020

gcacuuaacc aucugccucu agaauacaac ucugcuuugu acagccgaau auucgaugac     1080

uuugggacuc auuacuucac cucuggcucc cugggaggcg uguaugaccu ucucuaucag     1140

uuuagcagug aggaacuaaa gaacucaggu uuaaccgagg aagaagccaa acacuguguc     1200

aggauugaaa caaagaaacg cguuuuauuu gcuaagaaaa caaaagugga acauaggugc     1260

accaccaaca agcugucaga gaaacaugaa gguucauuua uacagggagc agagaaaucc     1320

auaucccuga uucgaggugg aaggagugaa uauggagcag cuuuggcaug ggagaaaggg     1380

agcucugguc uggaggagaa gacauuuucu gagugguuag aaucagugaa ggaaaauccu     1440

gcugugauug acuuugagcu ugcccccauc guggacuugg uaagaaacau ccccugugca     1500

gugacaaaac ggaacaaccu caggaaagcu uugcaagagu augcagccaa guucgauccu     1560

ugccagugug cuccaugccc uaauaauggc cgacccaccc ucucagggac ugaaugucug     1620

uguguguguc agaguggcac cuauggugag aacugugaga aacagucucc agauuauaaa     1680

uccaaugcag uagacggaca gugggguugu uggucuuccu ggaguaccug ugaugcuacu     1740

uauaagagau cgagaacccg agaaugcaau aauccugccc cccaacgagg agggaaacgc     1800

ugugaggggg agaagcgaca agaggaagac ugcacauuuu caaucaugga aaacaaugga     1860

caaccaugua ucaaugauga ugaagaaaug aaagaggucg aucuuccuga gauagaagca     1920

gauuccgggu guccucagcc aguuccucca gaaaauggau uuauccggaa ugaaaagcaa     1980

cuauacuugg uuggagaaga uguugaaauu ucaugccuua cuggcuuuga aacuguugga     2040

uaccaguacu ucagaugcuu accagacggg accuggagac aaggggaugu ggaaugccaa     2100

cggacggagu gcaucaagcc aguugugcag gaaguccuga caauuacacc auuucagaga     2160

uuguauagaa uuggugaauc cauugagcua acuugcccca aaggcuuugu uguugcuggg     2220

ccaucaaggu acacaugcca ggggaauucc uggacaccac ccauuucaaa cucucucacc     2280

ugugaaaaag auacucuaac aaaauuaaaa ggccauuguc agcugggaca gaaacaauca     2340

ggaucugaau gcauuuguau gucuccagaa gaagacugua gccaucauuc agaagaucuc     2400

uguguguuug acacagacuc caacgauuac uuuacuucac ccgcuuguaa guuuuuggcu     2460

gagaaauguu uaaauaauca gcaacuccau uuucuacaua uugguuccug ccaagacggc     2520

cgccaguuag aauggggucu ugaaaggaca agacuuucau ccaacagcac aaagaaagaa     2580

uccuguggcu augacaccug cuaugacugg gaaaaauguu cagccuccac uuccaaaugu     2640

gucugccuau ugcccccaca gugcuucaag gguggaaacc aacucuacug ugucaaaaug     2700

ggaucaucaa caagugagaa aacauugaac aucugugaag ugggaacuau aagaugugca     2760

aacaggaaga uggaaauacu gcauccugga aaguguuugg ccuag                     2805


<210>  8054
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8054
auggcccgcc ggagcgugcu guacuucauc cuccugaacg cccugaucaa caagggccag       60

gcgugcuucu gcgaccacua cgccuggacc caguggaccu ccugcagcaa gacgugcaac      120

uccgggaccc agagccgcca ccggcagauc gucguggaca aguacuacca ggagaacuuc      180

ugcgagcaga ucugcuccaa gcaggagacc cgcgagugca acuggcagcg gugccccauc      240

aacugccucc ugggcgacuu cgggccgugg agcgacugcg accccugcau cgagaagcag      300

uccaaggugc gcagcguccu gcggcccucc caguucggcg ggcagcccug caccgccccg      360

cucguggccu uccagcccug cauccccagc aagcugugca agaucgagga ggccgacugc      420

aagaacaagu uccgcugcga cuccggccgg ugcaucgcgc gcaagcugga gugcaacggc      480

gagaacgacu gcggggacaa cagcgacgag cgggacugcg gccgcacgaa ggccgugugc      540

acccggaagu acaaccccau cccguccguc cagcucaugg ggaacggcuu ccacuuccug      600

gccggggagc cccgcggcga ggugcuggac aacagcuuca ccggcgggau cugcaagacc      660

gugaagucca gccggacguc caaccccuac cgcguccccg ccaaccucga gaacgugggc      720

uucgaggugc agaccgcgga ggacgaccug aagaccgacu ucuacaagga ccugaccagc      780

cucgggcaca acgagaacca gcagggcucc uucagcagcc agggcggguc cagcuucucc      840

gucccgaucu ucuacagcuc caagcggagc gagaacauca accacaacuc cgccuucaag      900

caggccaucc aggccagcca caagaaggac uccagcuuca uccgcaucca caaggugaug      960

aaggugcuga acuucacgac caaggccaag gaccugcacc ucuccgacgu cuuccugaag     1020

gcgcugaacc accucccccu ggaguacaac agcgcccugu acucccggau cuucgacgac     1080

uucggcaccc acuacuucac cagcgggucc cucggcgggg uguacgaccu gcuguaccag     1140

uucagcuccg aggagcucaa gaacagcggc cugacggagg aggaggccaa gcacugcgug     1200

cgcaucgaga ccaagaagcg gguccuguuc gccaagaaga ccaaggugga gcaccgcugc     1260

accacgaaca agcucuccga gaagcacgag ggcagcuuca uccagggggc cgagaagucc     1320

aucagccuga uccgcggcgg gcggagcgag uacggcgcgg cccuggccug ggagaagggg     1380

uccagcggcc ucgaggagaa gaccuucucc gaguggcugg agagcgugaa ggagaacccc     1440

gccgucaucg acuucgagcu ggcccccauc guggaccucg ugcgcaacau cccgugcgcg     1500

gucaccaagc ggaacaaccu gcgcaaggcc cugcaggagu acgccgccaa guucgacccc     1560

ugccagugcg cccccugccc caacaacggc cggccgaccc ucuccgggac ggagugccug     1620

ugcgugugcc agagcggcac cuacggggag aacugcgaga agcagucccc cgacuacaag     1680

agcaacgcgg ucgacggcca gugggggugc ugguccagcu gguccacgug cgacgccacc     1740

uacaagcgca gccggacccg cgagugcaac aaccccgcgc cccagcgggg cggcaagcgc     1800

ugcgaggggg agaagcggca ggaggaggac ugcaccuucu ccaucaugga gaacaacggc     1860

cagccgugca ucaacgacga cgaggagaug aaggaggugg accugcccga gaucgaggcc     1920

gacagcgggu gcccccagcc cgugccgccc gagaacggcu ucauccgcaa cgagaagcag     1980

cucuaccugg ucggcgagga cguggagauc uccugccuga ccggguucga gaccgugggc     2040

uaccaguacu uccggugccu ccccgacggg acguggcgcc agggcgacgu cgagugccag     2100

cggaccgagu gcaucaagcc gguggugcag gagguccuga ccaucacccc cuuccagcgc     2160

cuguaccgga ucggggagag caucgagcuc acgugcccca agggcuucgu gguggccggc     2220

cccagccgcu acacgugcca ggggaacucc uggaccccgc ccaucagcaa cucccugacc     2280

ugcgagaagg acacccugac caagcugaag ggccacugcc agcucgggca gaagcagagc     2340

ggcuccgagu gcaucugcau gagccccgag gaggacugcu cccaccacag cgaggaccug     2400

ugcgucuucg acaccgacuc caacgacuac uucaccagcc ccgccugcaa guuccuggcc     2460

gagaagugcc ucaacaacca gcagcugcac uuccugcaca ucggguccug ccaggacggc     2520

cggcagcucg aguggggccu ggagcgcacc cgccugagcu ccaacagcac gaagaaggag     2580

uccugcgggu acgacacgug cuacgacugg gagaagugca gcgccuccac cagcaagugc     2640

gugugccucc ugccgcccca gugcuucaag ggcgggaacc agcuguacug cgugaagaug     2700

ggcuccagca ccagcgagaa gacccucaac aucugcgagg ucgggaccau ccggugcgcc     2760

aaccgcaaga uggagauccu gcaccccggc aagugccugg cguga                     2805


<210>  8055
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8055
auggcccgcc gcuccguccu cuacuucauc cuccucaacg cccucaucaa caagggccag       60

gccugcuucu gcgaccacua cgccuggacc caguggaccu ccugcuccaa gaccugcaac      120

uccggcaccc agucccgcca ccgccagauc gucgucgaca aguacuacca ggagaacuuc      180

ugcgagcaga ucugcuccaa gcaggagacc cgcgagugca acuggcagcg cugccccauc      240

aacugccucc ucggcgacuu cggccccugg uccgacugcg accccugcau cgagaagcag      300

uccaaggucc gcuccguccu ccgccccucc caguucggcg gccagcccug caccgccccc      360

cucgucgccu uccagcccug cauccccucc aagcucugca agaucgagga ggccgacugc      420

aagaacaagu uccgcugcga cuccggccgc ugcaucgccc gcaagcucga gugcaacggc      480

gagaacgacu gcggcgacaa cuccgacgag cgcgacugcg gccgcaccaa ggccgucugc      540

acccgcaagu acaaccccau ccccuccguc cagcucaugg gcaacggcuu ccacuuccuc      600

gccggcgagc cccgcggcga gguccucgac aacuccuuca ccggcggcau cugcaagacc      660

gucaaguccu cccgcaccuc caaccccuac cgcguccccg ccaaccucga gaacgucggc      720

uucgaggucc agaccgccga ggacgaccuc aagaccgacu ucuacaagga ccucaccucc      780

cucggccaca acgagaacca gcagggcucc uucuccuccc agggcggcuc cuccuucucc      840

guccccaucu ucuacuccuc caagcgcucc gagaacauca accacaacuc cgccuucaag      900

caggccaucc aggccuccca caagaaggac uccuccuuca uccgcaucca caaggucaug      960

aagguccuca acuucaccac caaggccaag gaccuccacc ucuccgacgu cuuccucaag     1020

gcccucaacc accucccccu cgaguacaac uccgcccucu acucccgcau cuucgacgac     1080

uucggcaccc acuacuucac cuccggcucc cucggcggcg ucuacgaccu ccucuaccag     1140

uucuccuccg aggagcucaa gaacuccggc cucaccgagg aggaggccaa gcacugcguc     1200

cgcaucgaga ccaagaagcg cguccucuuc gccaagaaga ccaaggucga gcaccgcugc     1260

accaccaaca agcucuccga gaagcacgag ggcuccuuca uccagggcgc cgagaagucc     1320

aucucccuca uccgcggcgg ccgcuccgag uacggcgccg cccucgccug ggagaagggc     1380

uccuccggcc ucgaggagaa gaccuucucc gaguggcucg aguccgucaa ggagaacccc     1440

gccgucaucg acuucgagcu cgcccccauc gucgaccucg uccgcaacau ccccugcgcc     1500

gucaccaagc gcaacaaccu ccgcaaggcc cuccaggagu acgccgccaa guucgacccc     1560

ugccagugcg cccccugccc caacaacggc cgccccaccc ucuccggcac cgagugccuc     1620

ugcgucugcc aguccggcac cuacggcgag aacugcgaga agcagucccc cgacuacaag     1680

uccaacgccg ucgacggcca guggggcugc ugguccuccu gguccaccug cgacgccacc     1740

uacaagcgcu cccgcacccg cgagugcaac aaccccgccc cccagcgcgg cggcaagcgc     1800

ugcgagggcg agaagcgcca ggaggaggac ugcaccuucu ccaucaugga gaacaacggc     1860

cagcccugca ucaacgacga cgaggagaug aaggaggucg accuccccga gaucgaggcc     1920

gacuccggcu gcccccagcc cguccccccc gagaacggcu ucauccgcaa cgagaagcag     1980

cucuaccucg ucggcgagga cgucgagauc uccugccuca ccggcuucga gaccgucggc     2040

uaccaguacu uccgcugccu ccccgacggc accuggcgcc agggcgacgu cgagugccag     2100

cgcaccgagu gcaucaagcc cgucguccag gagguccuca ccaucacccc cuuccagcgc     2160

cucuaccgca ucggcgaguc caucgagcuc accugcccca agggcuucgu cgucgccggc     2220

cccucccgcu acaccugcca gggcaacucc uggacccccc ccaucuccaa cucccucacc     2280

ugcgagaagg acacccucac caagcucaag ggccacugcc agcucggcca gaagcagucc     2340

ggcuccgagu gcaucugcau gucccccgag gaggacugcu cccaccacuc cgaggaccuc     2400

ugcgucuucg acaccgacuc caacgacuac uucaccuccc ccgccugcaa guuccucgcc     2460

gagaagugcc ucaacaacca gcagcuccac uuccuccaca ucggcuccug ccaggacggc     2520

cgccagcucg aguggggccu cgagcgcacc cgccucuccu ccaacuccac caagaaggag     2580

uccugcggcu acgacaccug cuacgacugg gagaagugcu ccgccuccac cuccaagugc     2640

gucugccucc ucccccccca gugcuucaag ggcggcaacc agcucuacug cgucaagaug     2700

ggcuccucca ccuccgagaa gacccucaac aucugcgagg ucggcaccau ccgcugcgcc     2760

aaccgcaaga uggagauccu ccaccccggc aagugccucg ccuga                     2805


<210>  8056
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8056
auggccagaa ggagcgugcu guacuucauc cuccuuaacg cucugauuaa uaagggccag       60

gcaugcuuuu gugaccacua ugccuggacc caauggacau ccugcucuaa aacuuguaac      120

ucagggacgc agagucggca ucgccagaua gucguugaua aguacuauca ggagaauuuc      180

ugcgaacaaa ucuguagcaa acaggagacc cgagaaugca acuggcagcg uugucccauu      240

aauugcuugu uaggagacuu ugguccuugg uccgauugug acccaugcau cgagaagcag      300

ucuaaaguga gaucgguacu gaggccguca caauucggcg ggcagcccug uacagcgccu      360

cuaguggcuu uucagccaug cauucccagc aagcucugca agaucgaaga ggccgauugu      420

aaaaacaagu uccggugcga caguggacgc uguauagcaa gaaaacugga gugcaauggc      480

gaaaacgauu guggugacaa uuccgaugag agggacugcg ggcggacuaa ggccgucugu      540

acccgcaaau acaacccuau cccaucugug cagcuuaugg gaaauggcuu ucacuuccug      600

gcuggcgaac cccgagggga gguuuuggau aacagcuuua caggagguau uugcaagacc      660

gugaaguccu caagaacaag uaauccuuau agggucccag caaaccucga gaaugugggc      720

uucgaaguac aaacagccga ggacgaucug aaaaccgacu uuuacaagga ccugacgagc      780

cucgggcaua acgaaaacca gcagggaucu uucuccucac aaggcgguag caguuuuucu      840

guuccgaucu ucuauuccag caaacggucg gagaauauua accacaauuc ugcuuucaag      900

caggccaucc aggcguccca uaaaaaggau ucaaguuuua uacguauuca caaagugaug      960

aaggucuuaa acuucacuac caaggcaaaa gaccugcacc uuagcgaugu guuuuugaag     1020

gcccugaauc aucuaccccu cgaauacaac uccgcucugu acucucgcau cuucgacgau     1080

uuugggacac acuauuucac uagcggauca cuuggcggcg uguacgaccu guuguaucag     1140

uuuaguuccg aggagcucaa aaauagcggg cugaccgaag aggaagccaa gcauuguguc     1200

agaauugaga cuaaaaagag gguuuuauuc gcaaagaaaa ccaaggugga acaccggugc     1260

acgacuaaca aacugucuga gaagcacgag ggaucauuua uccaaggugc ugagaaaagu     1320

aucagccuca uucgaggcgg gcgcuccgaa uacggagccg cgcuugccug ggaaaagggg     1380

ucuucggguc uggaggaaaa gacauucagc gagugguugg aguccguaaa agaaaauccu     1440

gcagugauag auuuugagcu agcuccaauc gucgaccugg ugagaaacau ucccugugcc     1500

guuaccaaga ggaauaaccu ccggaaagcu cugcaggaau augccgcaaa guucgauccu     1560

ugccagugcg ccccaugucc caauaacggg cgcccgacuc uuucaggcac agagugccug     1620

ugugugugcc agaguggaac cuacggcgag aauugugaaa aacaaucucc ugacuauaag     1680

agcaacgcug ucgaugggca guggggaugc ugguccucau ggagcacgug ugacgcgacc     1740

uacaagagau cuaggacacg ugagugcaac aaucccgcac cacagcgggg uggcaaacga     1800

ugugaagggg agaagagaca ggaagaggac ugcacuuuuu ccaucaugga gaacaaugga     1860

caaccuugua uaaacgauga cgaagagaug aaagaagugg auuugcccga gauugaagcc     1920

gacaguggcu gcccacagcc cguaccucca gagaaugguu ucaucaggaa cgagaagcag     1980

cucuaccugg uuggggaaga uguggagauc agcugcuuaa ccggcuucga aacagucgga     2040

uaucaguacu uucgcugucu gccggacggc acuuggcggc aaggggaugu ggagugccag     2100

agaaccgaau guauuaaacc cgucgugcag gagguucuaa caaucacccc uuuccaaagg     2160

cucuaucgca uuggagaguc uauagaacug acuugcccaa aggguuuugu gguagcuggc     2220

cccucccgau acacguguca gggcaauuca uggacaccuc caaucaguaa cagccuuacc     2280

ugcgagaaag acacuuugac caagcugaag ggacauuguc agcucggcca gaaacaaucg     2340

gguuccgaau gcauuuguau gucucccgag gaggauugca gccaccauuc agaagaccug     2400

ugugucuucg auacagacag uaaugauuau uuuaccuccc cggccugcaa guuccuugca     2460

gagaaaugcc ugaacaauca gcaguugcac uuucuccaua ucgggucuug ucaggacggc     2520

cggcaacugg aauggggauu agagcguacu agacugagcu ccaacucaac aaagaaagaa     2580

agcugcggcu acgacacgug uuaugauugg gagaagugca gugccucuac cuccaagugu     2640

gugugccuac ucccuccaca guguuucaaa gggggaaauc agcuguacug cguuaagaug     2700

ggcagcucga cuucagagaa aacacuuaac aucugugaag uggguaccau uaggugcgcu     2760

aaucgcaaga uggagauauu gcaccccggg aaaugucugg ccuga                     2805


<210>  8057
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8057
auggccagaa gaagcgugcu guacuucauc cugcugaacg cccugaucaa caagggccag       60

gccugcuucu gcgaccacua cgccuggacc caguggacca gcugcagcaa gaccugcaac      120

agcggcaccc agagcagaca cagacagauc gugguggaca aguacuacca ggagaacuuc      180

ugcgagcaga ucugcagcaa gcaggagacc agagagugca acuggcagag augccccauc      240

aacugccugc ugggcgacuu cggccccugg agcgacugcg accccugcau cgagaagcag      300

agcaagguga gaagcgugcu gagacccagc caguucggcg gccagcccug caccgccccc      360

cugguggccu uccagcccug cauccccagc aagcugugca agaucgagga ggccgacugc      420

aagaacaagu ucagaugcga cagcggcaga ugcaucgcca gaaagcugga gugcaacggc      480

gagaacgacu gcggcgacaa cagcgacgag agagacugcg gcagaaccaa ggccgugugc      540

accagaaagu acaaccccau ccccagcgug cagcugaugg gcaacggcuu ccacuuccug      600

gccggcgagc ccagaggcga ggugcuggac aacagcuuca ccggcggcau cugcaagacc      660

gugaagagca gcagaaccag caaccccuac agagugcccg ccaaccugga gaacgugggc      720

uucgaggugc agaccgccga ggacgaccug aagaccgacu ucuacaagga ccugaccagc      780

cugggccaca acgagaacca gcagggcagc uucagcagcc agggcggcag cagcuucagc      840

gugcccaucu ucuacagcag caagagaagc gagaacauca accacaacag cgccuucaag      900

caggccaucc aggccagcca caagaaggac agcagcuuca ucagaaucca caaggugaug      960

aaggugcuga acuucaccac caaggccaag gaccugcacc ugagcgacgu guuccugaag     1020

gcccugaacc accugccccu ggaguacaac agcgcccugu acagcagaau cuucgacgac     1080

uucggcaccc acuacuucac cagcggcagc cugggcggcg uguacgaccu gcuguaccag     1140

uucagcagcg aggagcugaa gaacagcggc cugaccgagg aggaggccaa gcacugcgug     1200

agaaucgaga ccaagaagag agugcuguuc gccaagaaga ccaaggugga gcacagaugc     1260

accaccaaca agcugagcga gaagcacgag ggcagcuuca uccagggcgc cgagaagagc     1320

aucagccuga ucagaggcgg cagaagcgag uacggcgccg cccuggccug ggagaagggc     1380

agcagcggcc uggaggagaa gaccuucagc gaguggcugg agagcgugaa ggagaacccc     1440

gccgugaucg acuucgagcu ggcccccauc guggaccugg ugagaaacau ccccugcgcc     1500

gugaccaaga gaaacaaccu gagaaaggcc cugcaggagu acgccgccaa guucgacccc     1560

ugccagugcg cccccugccc caacaacggc agacccaccc ugagcggcac cgagugccug     1620

ugcgugugcc agagcggcac cuacggcgag aacugcgaga agcagagccc cgacuacaag     1680

agcaacgccg uggacggcca guggggcugc uggagcagcu ggagcaccug cgacgccacc     1740

uacaagagaa gcagaaccag agagugcaac aaccccgccc cccagagagg cggcaagaga     1800

ugcgagggcg agaagagaca ggaggaggac ugcaccuuca gcaucaugga gaacaacggc     1860

cagcccugca ucaacgacga cgaggagaug aaggaggugg accugcccga gaucgaggcc     1920

gacagcggcu gcccccagcc cgugcccccc gagaacggcu ucaucagaaa cgagaagcag     1980

cuguaccugg ugggcgagga cguggagauc agcugccuga ccggcuucga gaccgugggc     2040

uaccaguacu ucagaugccu gcccgacggc accuggagac agggcgacgu ggagugccag     2100

agaaccgagu gcaucaagcc cguggugcag gaggugcuga ccaucacccc cuuccagaga     2160

cuguacagaa ucggcgagag caucgagcug accugcccca agggcuucgu gguggccggc     2220

cccagcagau acaccugcca gggcaacagc uggacccccc ccaucagcaa cagccugacc     2280

ugcgagaagg acacccugac caagcugaag ggccacugcc agcugggcca gaagcagagc     2340

ggcagcgagu gcaucugcau gagccccgag gaggacugca gccaccacag cgaggaccug     2400

ugcguguucg acaccgacag caacgacuac uucaccagcc ccgccugcaa guuccuggcc     2460

gagaagugcc ugaacaacca gcagcugcac uuccugcaca ucggcagcug ccaggacggc     2520

agacagcugg aguggggccu ggagagaacc agacugagca gcaacagcac caagaaggag     2580

agcugcggcu acgacaccug cuacgacugg gagaagugca gcgccagcac cagcaagugc     2640

gugugccugc ugccccccca gugcuucaag ggcggcaacc agcuguacug cgugaagaug     2700

ggcagcagca ccagcgagaa gacccugaac aucugcgagg ugggcaccau cagaugcgcc     2760

aacagaaaga uggagauccu gcaccccggc aagugccugg ccuga                     2805


<210>  8058
<211>  2805
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C6__Homo_sapiens__AAA51860

<400>  8058
auggccagac ggagcgugcu guacuucauc cuccugaacg cucuuauuaa uaagggccag       60

gccugcuuuu gugaccacua ugcguggacc caauggacau ccugcucuaa aacguguaac      120

agcgggaccc agucccgcca uagacagauc gucguugaua aguacuauca ggagaauuuc      180

ugcgaacaaa uuuguucuaa acaggagaca cgggaaugca acuggcagcg cugucccauc      240

aauugccugc ucggagacuu uggcccuugg agcgauugug acccgugcau ugagaagcag      300

uccaaaguga gaucugugcu gcggcccagc caauucgggg gacagccuug uaccgcuccc      360

cuugucgccu uucagccuug cauccccucc aagcugugca agaucgaaga ggccgauugu      420

aaaaacaagu uccgcugcga cagcggcaga uguauugcuc ggaaacucga gugcaauggg      480

gaaaacgauu guggagacaa uucugaugag cgcgacugcg gcagaacaaa ggccgugugu      540

acccggaaau acaacccuau cccguccguu cagcugaugg gcaauggguu ucacuuccug      600

gcuggagaac cccgcggcga ggugcucgau aacagcuuua cagggggaau uugcaagacc      660

gucaagucuu ccagaacgag caauccuuau cgggugcccg ccaaccugga gaauguuggc      720

uucgaagugc aaaccgcgga ggacgaucuu aaaacagacu uuuacaagga ccugaccucu      780

cucgggcaua acgaaaacca gcagggaucc uucagcuccc aaggcggcuc uagcuuuucc      840

gucccuaucu ucuauagcuc uaaacgcucc gagaauauua accacaauag cgccuucaag      900

caggcuaucc aggccucuca uaaaaaggau agcuccuuua uuagaaucca caaagugaug      960

aaggugcuga acuucacaac caaggcuaaa gaccuucacc ugucugaugu cuuucucaag     1020

gcccugaauc aucugccccu cgaauacaac agcgcgcugu acucccggau cuucgacgau     1080

uuugggacgc acuauuucac aagcggaucu cuuggcgggg uuuacgaccu gcucuaucag     1140

uuuuccagcg aggagcugaa aaauucugga cuuaccgaag aggaagccaa gcauugugug     1200

agaauugaga caaagaagcg cgugcuguuc gcuaagaaaa ccaaggucga acaccggugc     1260

accacaaaca aacucuccga gaagcacgag ggcagcuuua uccaaggggc cgaaaaaucc     1320

auuucucuga ucagaggagg ccgcagcgag uacggcgcug cccuggccug ggaaaagggg     1380

uccucuggac ucgaggaaaa gacguucagc gaguggcugg aguccgugaa agaaaauccg     1440

gcuguuauug auuuugagcu ugcgccuauc guggaccugg uccggaacau ccccugugcc     1500

gugaccaaga gaaauaaccu ccgcaaagcu cugcaggaau augccgccaa guucgauccu     1560

ugccagugcg cucccugucc caauaacggc cggccuacac uuagcgggac cgagugccug     1620

uguguuugcc agucuggaac auacggcgag aauugugaaa aacaaucccc ggacuauaag     1680

agcaacgccg uggaugggca guggggcugc uggucuuccu ggagcaccug ugacgcgacg     1740

uacaagagau cucgcacacg ggagugcaac aaucccgcuc cucagagagg aggcaaacgc     1800

ugugaagggg agaagcggca ggaagaggac ugcaccuuua gcauuaugga gaacaaugga     1860

caacccugua ucaacgauga cgaagagaug aaagaagucg aucucccuga gauugaagcc     1920

gacuccggcu gcccccagcc ggugccuccc gagaaugggu ucaucagaaa cgagaagcag     1980

cuguaccugg ucggagaaga uguggagauu agcugccuca ccggcuucga aacaguuggg     2040

uaucaguacu uucggugucu gccugacggc accuggcgcc aaggagaugu ggagugccag     2100

agaacagaau guaucaaacc cgucgugcag gagguucuua cgaucacccc uuuccaacgg     2160

cuguauagaa uuggcgaguc uaucgaacuc acaugcccca agggguuugu ggucgccgga     2220

ccgucccgcu acaccuguca gggcaauagc uggacaccuc ccauuuccaa cucucugacc     2280

ugcgagaaag acacgcugac caaacuuaag gggcauuguc agcucggaca gaaacaaagc     2340

ggcuccgaau gcaucuguau gucucccgag gaggauugca gccaccauuc cgaagaccug     2400

uguguguucg auacagacuc uaaugauuau uuuaccagcc cugcuugcaa guuccuggcc     2460

gagaaaugcc ucaacaauca gcagcugcac uuucuucaua uuggguccug ucaggacggc     2520

cggcaacugg aauggggacu cgagagaaca cgccugagcu cuaacuccac caagaaagaa     2580

agcugcggcu acgacacgug uuaugauugg gagaagugcu cugcuuccac aagcaagugu     2640

gugugccugc uuccgcccca guguuucaaa gggggaaauc agcucuacug cguuaagaug     2700

gggucuucca ccagcgagaa aacacugaac aucugugaag ucggcaccau uagaugcgcc     2760

aaucggaaga uggagauccu gcacccugga aaaugucucg cguga                     2805


<210>  8059
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C7__Homo_sapiens__P10643

<400>  8059

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210>  8060
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8060
augaagguga uaagcuuauu cauuuuggug ggauuuauag gagaguucca aaguuuuuca       60

agugccuccu cuccagucaa cugccagugg gacuucuaug ccccuugguc agaaugcaau      120

ggcuguacca agacucagac ucgcaggcgg ucaguugcug uguaugggca guauggaggc      180

cagccuugug uuggaaaugc uuuugaaaca caguccugug aaccuacaag aggaugucca      240

acagaggagg gauguggaga gcguuucagg ugcuuuucag gucagugcau cagcaaauca      300

uugguuugca auggggauuc ugacugugau gaagacagug cugaugaaga cagaugugag      360

gacucagaaa ggagaccuuc cugugauauc gauaaaccuc cuccuaacau agaacuuacu      420

ggaaaugguu acaaugaacu cacuggccag uuuaggaaca gagucaucaa uaccaaaagu      480

uuuggugguc aauguagaaa gguguuuagu ggggauggaa aagauuucua caggcugagu      540

ggaaaugucc uguccuauac auuccaggug aaaauaaaua augauuuuaa uuaugaauuu      600

uacaauagua cuuggucuua uguaaaacau acgucgacag aacacacauc aucuagucgg      660

aagcgcuccu uuuuuagauc uucaucaucu ucuucacgca guuauacuuc acauaccaau      720

gaaauccaua aaggaaagag uuaccaacug cugguuguug agaacacugu ugaaguggcu      780

caguucauua auaacaaucc agaauuuuua caacuugcug agccauucug gaaggagcuu      840

ucccaccucc ccucucugua ugacuacagu gccuaccgaa gauuaaucga ccaguacggg      900

acacauuauc ugcaaucugg gucguuagga ggagaauaca gaguucuauu uuauguggac      960

ucagaaaaau uaaaacaaaa ugauuuuaau ucagucgaag aaaagaaaug uaaauccuca     1020

gguuggcauu uugucguuaa auuuucaagu cauggaugca aggaacugga aaacgcuuua     1080

aaagcugcuu caggaaccca gaacaaugua uugcgaggag aaccguucau cagaggggga     1140

ggugcaggcu ucauaucugg ccuuaguuac cuagagcugg acaauccugc uggaaacaaa     1200

aggcgauauu cugccugggc agaaucugug acuaaucuuc cucaagucau aaaacaaaag     1260

cugacaccuu uauaugagcu gguaaaggaa guaccuugug ccucugugaa aaaacuauac     1320

cugaaauggg cucuugaaga guaucuggau gaauuugacc ccugucauug ccggccuugu     1380

caaaauggug guuuggcuac uguugagggg acccauuguc ugugccauug caaaccguac     1440

acauuuggug cggcguguga gcaaggaguc cucguaggga aucaagcagg agggguugau     1500

ggagguugga guugcugguc cucuuggagc cccugugucc aagggaagaa aacaagaagc     1560

cgugaaugca auaacccacc ucccaguggg ggugggagau ccugcguugg agaaacgaca     1620

gaaagcacac aaugcgaaga ugaggagcug gagcacuuga gguugcuuga accacauugc     1680

uuuccuuugu cuuugguucc aacagaauuc uguccaucac cuccugccuu gaaagaugga     1740

uuuguucaag augaagguac aauguuuccu guggggaaaa auguagugua cacuugcaau     1800

gaaggauacu cucuuauugg aaacccagug gccagaugug gagaagauuu acgguggcuu     1860

guuggggaaa ugcauuguca gaaaauugcc uguguucuac cuguacugau ggauggcaua     1920

cagagucacc cccaaaaacc uuucuacaca guuggugaga aggugacugu uuccuguuca     1980

gguggcaugu ccuuagaagg uccuucagca uuucucugug gcuccagccu uaaguggagu     2040

ccugagauga agaaugcccg cuguguacaa aaagaaaauc cguuaacaca ggcagugccu     2100

aaaugucagc gcugggagaa acugcagaau ucaagaugug uuuguaaaau gcccuacgaa     2160

uguggaccuu ccuuggaugu augugcucaa gaugagagaa gcaaaaggau acugccucug     2220

acaguuugca agaugcaugu ucuccacugu caggguagaa auuacacccu uacugguagg     2280

gacagcugua cucugccugc cucagcugag aaagcuugug gugccugccc acugugggga     2340

aaaugugaug cugagagcag caaauguguc ugccgagaag caucggagug cgaggaagaa     2400

ggguuuagca uuugugugga agugaacggc aaggagcaga cgaugucuga gugugaggcg     2460

ggcgcucuga gaugcagagg gcagagcauc ucugucacca gcauaaggcc uugugcugcg     2520

gaaacccagu ag                                                         2532


<210>  8061
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8061
augaagguga ucagccuguu cauccucguc ggcuucaucg gggaguucca guccuucagc       60

uccgccagcu cccccgugaa cugccagugg gacuucuacg ccccguggag cgagugcaac      120

ggcugcacca agacccagac gcgccggcgc uccguggcgg ucuacgggca guacggcggg      180

cagcccugcg ugggcaacgc cuucgagacc cagagcugcg agcccacccg gggcugcccc      240

accgaggagg ggugcggcga gcgcuuccgg ugcuucuccg ggcagugcau cagcaagucc      300

cuggugugca acggcgacag cgacugcgac gaggacuccg ccgacgagga ccgcugcgag      360

gacagcgagc ggcgcccguc cugcgacauc gacaagcccc cgcccaacau cgagcugacg      420

gggaacggcu acaacgagcu caccggccag uuccggaacc gcgucaucaa caccaagagc      480

uucgggggcc agugccggaa gguguucucc ggggacggca aggacuucua ccgccugagc      540

ggcaacgugc uguccuacac cuuccagguc aagaucaaca acgacuucaa cuacgaguuc      600

uacaacagca cguggagcua cgugaagcac accuccaccg agcacaccag cuccagccgg      660

aagcgcuccu ucuuccggag cuccagcucc agcucccgca gcuacacguc ccacaccaac      720

gagauccaca agggcaagag cuaccagcuc cugguggucg agaacaccgu ggagguggcc      780

caguucauca acaacaaccc cgaguuccug cagcucgccg agcccuucug gaaggagcug      840

ucccaccucc ccagccugua cgacuacucc gcguaccggc gccugaucga ccaguacggg      900

acccacuacc ugcagagcgg gucccucggc ggggaguacc ggguccuguu cuacguggac      960

agcgagaagc ugaagcagaa cgacuucaac agcguggagg agaagaagug caaguccagc     1020

ggcuggcacu ucgucgugaa guucuccagc cacggcugca aggagcucga gaacgcccug     1080

aaggccgccu ccgggacgca gaacaacgug cugcgcggcg agcccuucau ccgcgggggc     1140

ggggcgggcu ucaucagcgg ccucuccuac cuggagcugg acaacccggc cgggaacaag     1200

cggcgcuaca gcgccugggc cgaguccguc accaaccucc cccaggugau caagcagaag     1260

cugacgcccc uguacgagcu cgugaaggag guccccugcg ccagcgugaa gaagcuguac     1320

cugaaguggg cgcucgagga guaccuggac gaguucgacc cgugccacug ccggcccugc     1380

cagaacggcg ggcuggccac cgucgagggc acccacugcc ucugccacug caagcccuac     1440

accuucgggg ccgccugcga gcagggcgug cuggugggca accaggccgg gggcgucgac     1500

gggggcuggu ccugcuggag cuccuggagc cccugcgugc agggcaagaa gacccgcucc     1560

cgggagugca acaacccgcc gcccagcggg ggcgggcgcu ccugcguggg cgagaccacg     1620

gagagcaccc agugcgagga cgaggagcug gagcaccucc ggcugcugga gccccacugc     1680

uucccccuca gccugguccc caccgaguuc ugccccuccc cgcccgcgcu gaaggacggg     1740

uucgugcagg acgagggcac cauguucccc gugggcaaga acgucgugua cacgugcaac     1800

gagggguaca gccucaucgg caaccccgug gcccgcugcg gggaggaccu gcgguggcug     1860

gucggcgaga ugcacugcca gaagaucgcc ugcgugcucc cggugcugau ggacgggauc     1920

cagucccacc cccagaagcc cuucuacacc gucggcgaga aggugaccgu gagcugcucc     1980

ggcgggauga gccuggaggg ccccuccgcc uuccucugcg ggagcucccu gaaguggagc     2040

ccggagauga agaacgcccg cugcguccag aaggagaacc cccugaccca ggcggugccc     2100

aagugccagc ggugggagaa gcugcagaac ucccgcugcg ugugcaagau gcccuacgag     2160

ugcggcccga gccucgacgu cugcgcccag gacgagcggu ccaagcgcau ccugccccug     2220

acggugugca agaugcacgu gcuccacugc caggggcgga acuacacccu gaccggccgc     2280

gacagcugca cccugcccgc cuccgccgag aaggccugcg gcgcgugccc ccucuggggg     2340

aagugcgacg ccgagagcuc caagugcguc ugccgggagg ccagcgagug cgaggaggag     2400

ggcuucucca ucugcgugga ggugaacggg aaggagcaga cgaugagcga gugcgaggcc     2460

ggcgcgcugc gcugccgggg gcagagcauc uccgucacca gcauccgccc gugcgccgcc     2520

gagacccagu ga                                                         2532


<210>  8062
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8062
augaagguca ucucccucuu cauccucguc ggcuucaucg gcgaguucca guccuucucc       60

uccgccuccu cccccgucaa cugccagugg gacuucuacg cccccugguc cgagugcaac      120

ggcugcacca agacccagac ccgccgccgc uccgucgccg ucuacggcca guacggcggc      180

cagcccugcg ucggcaacgc cuucgagacc caguccugcg agcccacccg cggcugcccc      240

accgaggagg gcugcggcga gcgcuuccgc ugcuucuccg gccagugcau cuccaagucc      300

cucgucugca acggcgacuc cgacugcgac gaggacuccg ccgacgagga ccgcugcgag      360

gacuccgagc gccgccccuc cugcgacauc gacaagcccc cccccaacau cgagcucacc      420

ggcaacggcu acaacgagcu caccggccag uuccgcaacc gcgucaucaa caccaagucc      480

uucggcggcc agugccgcaa ggucuucucc ggcgacggca aggacuucua ccgccucucc      540

ggcaacgucc ucuccuacac cuuccagguc aagaucaaca acgacuucaa cuacgaguuc      600

uacaacucca ccugguccua cgucaagcac accuccaccg agcacaccuc cuccucccgc      660

aagcgcuccu ucuuccgcuc cuccuccucc uccucccgcu ccuacaccuc ccacaccaac      720

gagauccaca agggcaaguc cuaccagcuc cucgucgucg agaacaccgu cgaggucgcc      780

caguucauca acaacaaccc cgaguuccuc cagcucgccg agcccuucug gaaggagcuc      840

ucccaccucc ccucccucua cgacuacucc gccuaccgcc gccucaucga ccaguacggc      900

acccacuacc uccaguccgg cucccucggc ggcgaguacc gcguccucuu cuacgucgac      960

uccgagaagc ucaagcagaa cgacuucaac uccgucgagg agaagaagug caaguccucc     1020

ggcuggcacu ucgucgucaa guucuccucc cacggcugca aggagcucga gaacgcccuc     1080

aaggccgccu ccggcaccca gaacaacguc cuccgcggcg agcccuucau ccgcggcggc     1140

ggcgccggcu ucaucuccgg ccucuccuac cucgagcucg acaaccccgc cggcaacaag     1200

cgccgcuacu ccgccugggc cgaguccguc accaaccucc cccaggucau caagcagaag     1260

cucacccccc ucuacgagcu cgucaaggag guccccugcg ccuccgucaa gaagcucuac     1320

cucaaguggg cccucgagga guaccucgac gaguucgacc ccugccacug ccgccccugc     1380

cagaacggcg gccucgccac cgucgagggc acccacugcc ucugccacug caagcccuac     1440

accuucggcg ccgccugcga gcagggcguc cucgucggca accaggccgg cggcgucgac     1500

ggcggcuggu ccugcugguc cuccuggucc cccugcgucc agggcaagaa gacccgcucc     1560

cgcgagugca acaacccccc ccccuccggc ggcggccgcu ccugcgucgg cgagaccacc     1620

gaguccaccc agugcgagga cgaggagcuc gagcaccucc gccuccucga gccccacugc     1680

uucccccucu cccucguccc caccgaguuc ugccccuccc cccccgcccu caaggacggc     1740

uucguccagg acgagggcac cauguucccc gucggcaaga acgucgucua caccugcaac     1800

gagggcuacu cccucaucgg caaccccguc gcccgcugcg gcgaggaccu ccgcuggcuc     1860

gucggcgaga ugcacugcca gaagaucgcc ugcguccucc ccguccucau ggacggcauc     1920

cagucccacc cccagaagcc cuucuacacc gucggcgaga aggucaccgu cuccugcucc     1980

ggcggcaugu cccucgaggg ccccuccgcc uuccucugcg gcuccucccu caaguggucc     2040

cccgagauga agaacgcccg cugcguccag aaggagaacc cccucaccca ggccgucccc     2100

aagugccagc gcugggagaa gcuccagaac ucccgcugcg ucugcaagau gcccuacgag     2160

ugcggccccu cccucgacgu cugcgcccag gacgagcgcu ccaagcgcau ccucccccuc     2220

accgucugca agaugcacgu ccuccacugc cagggccgca acuacacccu caccggccgc     2280

gacuccugca cccuccccgc cuccgccgag aaggccugcg gcgccugccc ccucuggggc     2340

aagugcgacg ccgaguccuc caagugcguc ugccgcgagg ccuccgagug cgaggaggag     2400

ggcuucucca ucugcgucga ggucaacggc aaggagcaga ccauguccga gugcgaggcc     2460

ggcgcccucc gcugccgcgg ccaguccauc uccgucaccu ccauccgccc cugcgccgcc     2520

gagacccagu ga                                                         2532


<210>  8063
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8063
augaagguga ucagccuguu cauucucguc ggcuuuauag gggaguucca guccuuuucu       60

ucagccagua gccccguuaa cugccaaugg gacuucuacg cuccuugguc cgaauguaau      120

ggaugcacca aaacacagac uagaaggcgg ucuguggcag uauaugguca guacggcggg      180

cagccaugug ugggaaacgc cuuugagacg caaucgugcg aaccgacccg cggcuguccc      240

acagaggaag guugcgggga gcgauuccgu uguuuuucag gacagugcau cagcaagagu      300

cuugucugua auggcgauuc cgacugcgau gaggacucug cggaugaaga cagaugugag      360

gauagcgaaa ggcggccuuc cugcgacauu gauaaaccac ccccuaacau cgagcugacu      420

ggcaaugggu auaacgaguu gaccggacag uuccgcaaua gagugauuaa cacaaaguca      480

uuugguggcc agugcaggaa aguuuucagu ggggacggaa aggauuuuua ccgguuaagc      540

ggcaaugugc ugucuuauac cuuccaaguc aagaucaaca augacuuuaa cuacgaguuc      600

uauaauucca cuuggucaua cgugaaacac acaagcaccg agcauacgag uucuucccgc      660

aagaggagcu ucuuuagauc gucuuccuca aguagcaggu ccuacacuuc ucacaccaac      720

gaaauacaua aagguaagag cuaucagcua cucguaguug agaauacagu ggaagucgcu      780

caguucauca acaacaaucc agaguuucug cagcuugccg agcccuucug gaaagaacug      840

ucacacuugc cuagucucua cgauuauucc gcauaccggc gucugauuga ccaauauggg      900

acucauuacc ugcagagcgg aucucucggc ggcgaguauc gcguguuauu uuacguggac      960

ucagaaaagc ugaagcagaa cgauuucaau agugucgagg agaaaaagug uaaaagcucc     1020

ggguggcacu uuguugugaa guucucuucg cacggaugca aagaacuuga gaacgccuug     1080

aaggcugcaa gcgguaccca aaauaacgua cugagaggcg aaccauuuau ccgaggggga     1140

ggcgccgguu ucauuuccgg gcuaucauac cucgagcugg acaauccggc uggcaacaaa     1200

cggcgauaua gugccugggc ggaaucugug acaaaucuuc cccaggucau caagcagaag     1260

cugaccccuu uguacgagcu cgugaaagaa guuccaugug caagcgugaa gaaacuguau     1320

uuaaaguggg cccuggagga guaccucgau gaauuugacc ccugccauug ucgcccuugc     1380

cagaacggag gccuugcuac ggucgagggg acucacuguc ugugccauug uaaaccauau     1440

acauucggag ccgcaugcga acaaggugug uugguaggca aucaggcugg gggaguugau     1500

ggcgguuggu ccuguugguc aagcuggucu cccugcgugc aggggaagaa gaccagaucc     1560

agggagugca acaauccgcc ucccaguggc ggaggccgga gcugugucgg ggagacuaca     1620

gaaucuaccc agugcgagga cgaagaacua gaacaucugc gccuccugga gccacacugu     1680

uuuccucuuu cccuggugcc cacggaguuc ugcccaucac ccccugccuu gaaagaugga     1740

uucguccaag acgaagguac cauguuucca gugggcaaga acguugugua cacauguaau     1800

gagggguaua gucucauagg aaacccggua gcgagaugcg gcgaagaucu gaggugguua     1860

gucggugaga ugcacuguca gaaaauugcc ugcgugcugc ccguucuaau ggacgggauc     1920

cagagccacc cucagaagcc auucuacacu gugggcgaaa aagucaccgu gucguguucc     1980

ggaggcaugu cucucgaggg gcccagcgca uuucugugcg gaucaagucu uaaguggucc     2040

ccugagauga agaacgcucg uuguguacaa aaagaaaauc cauugacaca ggccgugccc     2100

aagugccagc ggugggagaa acugcagaac ucucgaugcg uuuguaagau gccguacgaa     2160

ugcggcccua gccucgaugu cugugcucaa gacgagagau ccaaaaggau ucugccacuu     2220

acugugugca agaugcaugu gcugcacugu cagggucgca auuauaccuu gacagggcgg     2280

gacucaugca cccuccccgc cagcgcagaa aaggccugug gagcuugccc ucuguggggc     2340

aaaugugaug cggagaguuc uaagugcguc uguagagagg cauccgaaug cgaggaagag     2400

gguuucagca ucugcguuga ggugaacggc aaagaacaga cuaugucgga gugugaagcc     2460

ggggcuuuaa ggugccgcgg acaaucaauc ucugugacga guauucgacc cugugccgca     2520

gagacacagu ga                                                         2532


<210>  8064
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8064
augaagguga ucagccuguu cauccuggug ggcuucaucg gcgaguucca gagcuucagc       60

agcgccagca gccccgugaa cugccagugg gacuucuacg cccccuggag cgagugcaac      120

ggcugcacca agacccagac cagaagaaga agcguggccg uguacggcca guacggcggc      180

cagcccugcg ugggcaacgc cuucgagacc cagagcugcg agcccaccag aggcugcccc      240

accgaggagg gcugcggcga gagauucaga ugcuucagcg gccagugcau cagcaagagc      300

cuggugugca acggcgacag cgacugcgac gaggacagcg ccgacgagga cagaugcgag      360

gacagcgaga gaagacccag cugcgacauc gacaagcccc cccccaacau cgagcugacc      420

ggcaacggcu acaacgagcu gaccggccag uucagaaaca gagugaucaa caccaagagc      480

uucggcggcc agugcagaaa gguguucagc ggcgacggca aggacuucua cagacugagc      540

ggcaacgugc ugagcuacac cuuccaggug aagaucaaca acgacuucaa cuacgaguuc      600

uacaacagca ccuggagcua cgugaagcac accagcaccg agcacaccag cagcagcaga      660

aagagaagcu ucuucagaag cagcagcagc agcagcagaa gcuacaccag ccacaccaac      720

gagauccaca agggcaagag cuaccagcug cugguggugg agaacaccgu ggagguggcc      780

caguucauca acaacaaccc cgaguuccug cagcuggccg agcccuucug gaaggagcug      840

agccaccugc ccagccugua cgacuacagc gccuacagaa gacugaucga ccaguacggc      900

acccacuacc ugcagagcgg cagccugggc ggcgaguaca gagugcuguu cuacguggac      960

agcgagaagc ugaagcagaa cgacuucaac agcguggagg agaagaagug caagagcagc     1020

ggcuggcacu ucguggugaa guucagcagc cacggcugca aggagcugga gaacgcccug     1080

aaggccgcca gcggcaccca gaacaacgug cugagaggcg agcccuucau cagaggcggc     1140

ggcgccggcu ucaucagcgg ccugagcuac cuggagcugg acaaccccgc cggcaacaag     1200

agaagauaca gcgccugggc cgagagcgug accaaccugc cccaggugau caagcagaag     1260

cugacccccc uguacgagcu ggugaaggag gugcccugcg ccagcgugaa gaagcuguac     1320

cugaaguggg cccuggagga guaccuggac gaguucgacc ccugccacug cagacccugc     1380

cagaacggcg gccuggccac cguggagggc acccacugcc ugugccacug caagcccuac     1440

accuucggcg ccgccugcga gcagggcgug cuggugggca accaggccgg cggcguggac     1500

ggcggcugga gcugcuggag cagcuggagc cccugcgugc agggcaagaa gaccagaagc     1560

agagagugca acaacccccc ccccagcggc ggcggcagaa gcugcguggg cgagaccacc     1620

gagagcaccc agugcgagga cgaggagcug gagcaccuga gacugcugga gccccacugc     1680

uucccccuga gccuggugcc caccgaguuc ugccccagcc cccccgcccu gaaggacggc     1740

uucgugcagg acgagggcac cauguucccc gugggcaaga acguggugua caccugcaac     1800

gagggcuaca gccugaucgg caaccccgug gccagaugcg gcgaggaccu gagauggcug     1860

gugggcgaga ugcacugcca gaagaucgcc ugcgugcugc ccgugcugau ggacggcauc     1920

cagagccacc cccagaagcc cuucuacacc gugggcgaga aggugaccgu gagcugcagc     1980

ggcggcauga gccuggaggg ccccagcgcc uuccugugcg gcagcagccu gaaguggagc     2040

cccgagauga agaacgccag augcgugcag aaggagaacc cccugaccca ggccgugccc     2100

aagugccaga gaugggagaa gcugcagaac agcagaugcg ugugcaagau gcccuacgag     2160

ugcggcccca gccuggacgu gugcgcccag gacgagagaa gcaagagaau ccugccccug     2220

accgugugca agaugcacgu gcugcacugc cagggcagaa acuacacccu gaccggcaga     2280

gacagcugca cccugcccgc cagcgccgag aaggccugcg gcgccugccc ccuguggggc     2340

aagugcgacg ccgagagcag caagugcgug ugcagagagg ccagcgagug cgaggaggag     2400

ggcuucagca ucugcgugga ggugaacggc aaggagcaga ccaugagcga gugcgaggcc     2460

ggcgcccuga gaugcagagg ccagagcauc agcgugacca gcaucagacc cugcgccgcc     2520

gagacccagu ga                                                         2532


<210>  8065
<211>  2532
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C7__Homo_sapiens__AAH63851

<400>  8065
augaagguga ucagccuguu cauucucguc ggcuuuaucg gggaguucca guccuuuucu       60

agcgccuccu cucccguuaa cugccaaugg gacuucuacg cuccuuggag cgaauguaau      120

ggaugcacca aaacacagac gagacggcgc uccguggccg uguauggcca guacggggga      180

cagccgugug ucggcaacgc guuugagacc caaucuugcg aacccacaag aggguguccu      240

accgaggaag gaugcggcga gcgguuccgc uguuuuagcg gccagugcau uuccaagagc      300

cuggugugua auggggauuc ugacugcgau gaggacuccg cugaugaaga cagaugugag      360

gauagcgaac ggcgccccuc uugcgacauc gauaaaccuc ccccuaacau ugagcuuaca      420

ggaaauggcu auaacgagcu gaccgggcag uucagaaauc ggguuaucaa cacaaagucc      480

uuuggaggcc agugccgcaa aguguucagc ggggacggaa aggauuuuua cagacucucu      540

ggcaaugucc uguccuauac cuuccaagug aagaucaaca augacuuuaa cuacgaguuc      600

uauaauagca cgugguccua cguuaaacac accucuacag agcauaccag cuccagccgg      660

aagcgcucuu ucuuuagauc cagcucuagc uccucucgga gcuacacauc ccacaccaac      720

gaaauucaua aaggcaagag cuaucagcuu cugguggucg agaauacggu ggaaguggcc      780

caguucauca acaacaaucc ggaguuucuc cagcuggccg agcccuucug gaaagaacug      840

ucucaccucc cuucccugua cgauuauagc gcuuaccgca gacuuauuga ccaauauggg      900

acacauuacc ugcagucugg aucccucggc ggggaguauc ggguccuguu uuacguugac      960

agcgaaaaac uuaagcagaa cgauuucaau uccguggagg aaaagaagug uaaaucuagc     1020

ggauggcacu uuguggucaa guucuccucu cacggcugca aagagcugga gaacgcccuc     1080

aaggcugcca gcgggaccca aaauaacgug cugagaggag aacccuuuau ccgcggcggc     1140

ggggcgggau ucauuuccgg ccugagcuac cucgagcugg acaauccugc cgggaacaaa     1200

cggagauauu cugcuugggc cgaauccguu acaaaucuuc cccaggugau caagcagaag     1260

cugaccccgc ucuacgagcu ggucaaagaa gugccuugug cuagcguuaa gaaacuuuau     1320

cugaaguggg cccucgagga guaccuggau gaauuugacc ccugccauug ucgcccuugc     1380

cagaacggag gccuggcgac cguggagggg acacacuguc ucugccauug uaaacccuau     1440

acguucggcg ccgcuugcga acaaggaguc cuggugggca aucaggccgg gggagucgau     1500

ggcggguggu cuuguugguc cagcuggucu cccugcgugc agggaaagaa gacccggagc     1560

agagagugca acaauccucc gcccuccggc gggggccgca gcuguguugg agagacaacc     1620

gaaucuacac agugcgagga cgaagaacuu gaacaucugc ggcuccugga gccucacugu     1680

uuuccccuuu cccuggugcc uaccgaguuc ugccccagcc cgccugcucu caaagauggc     1740

uucguccaag acgaagggac gauguuuccc gugggaaaga acguugugua cacauguaau     1800

gagggcuauu cccugauugg gaacccuguc gccagaugcg gagaagaucu gcgcuggcuc     1860

gugggcgaga ugcacuguca gaaaaucgcc ugcgugcugc ccguucuuau ggacgggauc     1920

cagucucacc cucagaagcc cuucuacacc gucggcgaaa aagugaccgu gagcuguucc     1980

ggaggcaugu cucuggaggg gccgagcgcu uuucucugcg gauccucucu gaaguggagc     2040

ccugagauga agaacgcgcg guguguccaa aaagaaaauc cccugacaca ggccgugccc     2100

aagugccaga gaugggagaa acuucagaac ucccgcugcg uuuguaagau gccuuacgaa     2160

ugcggcccga gccucgaugu gugugcucaa gacgagcggu cuaaacggau ucugccccug     2220

accgucugca agaugcaugu gcuccacugu caggggagaa auuauacacu gacgggacgc     2280

gacuccugca cccuuccugc cagcgccgaa aaggcuugug gcgccugccc ccuguggggg     2340

aaaugugaug cggagucuuc caagugcguu uguagagagg cuagcgaaug cgaggaagag     2400

ggcuucucua ucugcgugga ggucaacgga aaagaacaga caauguccga gugugaagcc     2460

ggcgcccucc ggugcagagg gcaaagcauu uccgugacca gcauccgccc uugugcugcc     2520

gagacacagu ga                                                         2532


<210>  8066
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C8__Homo_sapiens__Q99618

<400>  8066

Met Gly Ser Ala Lys Ser Val Pro Val Thr Pro Ala Arg Pro Pro Pro 
1               5                   10                  15      


His Asn Lys His Leu Ala Arg Val Ala Asp Pro Arg Ser Pro Ser Ala 
            20                  25                  30          


Gly Ile Leu Arg Thr Pro Ile Gln Val Glu Ser Ser Pro Gln Pro Gly 
        35                  40                  45              


Leu Pro Ala Gly Glu Gln Leu Glu Gly Leu Lys His Ala Gln Asp Ser 
    50                  55                  60                  


Asp Pro Arg Ser Pro Thr Leu Gly Ile Ala Arg Thr Pro Met Lys Thr 
65                  70                  75                  80  


Ser Ser Gly Asp Pro Pro Ser Pro Leu Val Lys Gln Leu Ser Glu Val 
                85                  90                  95      


Phe Glu Thr Glu Asp Ser Lys Ser Asn Leu Pro Pro Glu Pro Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Pro Leu Ser Ser Glu Leu Asp Leu Pro Leu Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Glu Glu Gln Met Pro Pro Trp Asn Gln Thr Glu Phe 
    130                 135                 140                 


Pro Ser Lys Gln Val Phe Ser Lys Glu Glu Ala Arg Gln Pro Thr Glu 
145                 150                 155                 160 


Thr Pro Val Ala Ser Gln Ser Ser Asp Lys Pro Ser Arg Asp Pro Glu 
                165                 170                 175     


Thr Pro Arg Ser Ser Gly Ser Met Arg Asn Arg Trp Lys Pro Asn Ser 
            180                 185                 190         


Ser Lys Val Leu Gly Arg Ser Pro Leu Thr Ile Leu Gln Asp Asp Asn 
        195                 200                 205             


Ser Pro Gly Thr Leu Thr Leu Arg Gln Gly Lys Arg Pro Ser Pro Leu 
    210                 215                 220                 


Ser Glu Asn Val Ser Glu Leu Lys Glu Gly Ala Ile Leu Gly Thr Gly 
225                 230                 235                 240 


Arg Leu Leu Lys Thr Gly Gly Arg Ala Trp Glu Gln Gly Gln Asp His 
                245                 250                 255     


Asp Lys Glu Asn Gln His Phe Pro Leu Val Glu Ser 
            260                 265             


<210>  8067
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8067
augggcucag ccaagagcgu cccagucaca ccagcgcggc cuccgccgca caacaagcau       60

cuggcucgag uggcggaccc ccguucaccu agugcuggca uccugcgcac ucccauccag      120

guggagagcu cuccacagcc aggccuacca gcaggggagc aacuggaggg ucuuaaacau      180

gcccaggacu cagauccccg cucuccuacu cuugguauug cacggacacc uaugaagacc      240

agcaguggag accccccaag cccacuggug aaacagcuga gugaaguauu ugaaacugaa      300

gacucuaaau caaaucuucc cccagagccu guucugcccc cagaggcacc uuuaucuucu      360

gaauuggacu ugccucuggg uacccaguua ucuguugagg aacagaugcc accuuggaac      420

cagacugagu uccccuccaa acagguguuu uccaaggagg aagcaagaca gcccacagaa      480

accccugugg ccagccagag cuccgacaag cccucaaggg acccugagac ucccagaucu      540

ucagguucua ugcgcaauag auggaaacca aacagcagca agguacuagg gagauccccc      600

cucaccaucc ugcaggauga caacuccccu ggcacccuga cacuacgaca ggguaagcgg      660

ccuucacccc uaagugaaaa uguuagugaa cuaaaggaag gagccauucu uggaacugga      720

cgacuucuga aaacuggagg acgagcaugg gagcaaggcc aggaccauga caaggaaaau      780

cagcacuuuc ccuuggugga gagcuag                                          807


<210>  8068
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8068
augggcagcg ccaaguccgu gcccgucacc ccggcccgcc cgccgcccca caacaagcac       60

cuggcgcggg uggccgaccc ccgcagcccc uccgccggga uccuccggac ccccauccag      120

guggagagca gcccccagcc cggccugccc gccggggagc agcuggaggg ccucaagcac      180

gcccaggacu ccgacccccg cucccccacg cuggggaucg cgcggacccc gaugaagacc      240

agcuccggcg acccgcccag cccccugguc aagcagcucu ccgagguguu cgagaccgag      300

gacagcaagu ccaaccugcc gcccgagccc gugcugccgc ccgaggcgcc ccucagcucc      360

gagcuggacc ugccccucgg cacgcagcug agcgucgagg agcagaugcc gcccuggaac      420

cagaccgagu uccccuccaa gcaggucuuc agcaaggagg aggcccgcca gcccaccgag      480

acccccgugg ccucccagag cagcgacaag cccucccggg accccgagac gccccgcagc      540

uccgggagca ugcggaaccg cuggaagccg aacuccagca aggugcuggg ccggagcccc      600

cucaccaucc ugcaggacga caacuccccc gggacccuga cccuccgcca gggcaagcgg      660

cccuccccgc ugagcgagaa cguguccgag cugaaggagg gggccauccu cggcacgggc      720

cgccugcuga agaccggggg ccgggccugg gagcaggggc aggaccacga caaggagaac      780

cagcacuucc cccucgugga gagcuga                                          807


<210>  8069
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8069
augggcuccg ccaaguccgu ccccgucacc cccgcccgcc ccccccccca caacaagcac       60

cucgcccgcg ucgccgaccc ccgcuccccc uccgccggca uccuccgcac ccccauccag      120

gucgaguccu ccccccagcc cggccucccc gccggcgagc agcucgaggg ccucaagcac      180

gcccaggacu ccgacccccg cucccccacc cucggcaucg cccgcacccc caugaagacc      240

uccuccggcg acccccccuc cccccucguc aagcagcucu ccgaggucuu cgagaccgag      300

gacuccaagu ccaaccuccc ccccgagccc guccuccccc ccgaggcccc ccucuccucc      360

gagcucgacc ucccccucgg cacccagcuc uccgucgagg agcagaugcc ccccuggaac      420

cagaccgagu uccccuccaa gcaggucuuc uccaaggagg aggcccgcca gcccaccgag      480

acccccgucg ccucccaguc cuccgacaag cccucccgcg accccgagac cccccgcucc      540

uccggcucca ugcgcaaccg cuggaagccc aacuccucca agguccucgg ccgcuccccc      600

cucaccaucc uccaggacga caacuccccc ggcacccuca cccuccgcca gggcaagcgc      660

cccucccccc ucuccgagaa cgucuccgag cucaaggagg gcgccauccu cggcaccggc      720

cgccuccuca agaccggcgg ccgcgccugg gagcagggcc aggaccacga caaggagaac      780

cagcacuucc cccucgucga guccuga                                          807


<210>  8070
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8070
augggcagcg ccaaguccgu gcccgucacc ccugcuagac caccgcccca caacaaacau       60

cuggcaaggg uugccgaccc ucggucucca ucagcgggga uccuccgcac acccauucag      120

guggagagua gcccucaacc aggacuuccc gcuggugaac agcuggaggg cuugaagcac      180

gcccaggauu ccgacccucg aucuccaacu uuagggauag cacguacgcc gaugaaaacc      240

ucgucaggag aucccccuag cccacuggua aagcagcuaa gugaaguguu cgagacagaa      300

gacuccaaau cuaaucuccc ucccgagcca guccugcccc cggaggcccc ucuuagcucc      360

gaacuggauu ugccccucgg cacucaacug ucaguggagg aacagaugcc accuuggaac      420

cagaccgagu uucccaguaa gcagguuuuc agcaaggagg aagcuagaca accaacagag      480

acccccgugg caucucaguc cucagacaaa ccuagcaggg auccagaaac uccgcggagu      540

ucugguucca ugcgcaauag auggaagccc aacagcucga aaguccuggg gaggucuccu      600

cucacaaucu uacaggacga uaauucccca ggaacccuga cgcuucggca gggcaagcgc      660

cccucaccuu ugagugagaa cgugagcgaa cugaaagagg gcgccauucu agggacugga      720

cgacuccuga agaccggugg cagagcuugg gagcaagggc aggaccauga uaaggaaaau      780

cagcacuuuc cacuuguaga guccuga                                          807


<210>  8071
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8071
augggcagcg ccaagagcgu gcccgugacc cccgccagac ccccccccca caacaagcac       60

cuggccagag uggccgaccc cagaagcccc agcgccggca uccugagaac ccccauccag      120

guggagagca gcccccagcc cggccugccc gccggcgagc agcuggaggg ccugaagcac      180

gcccaggaca gcgaccccag aagccccacc cugggcaucg ccagaacccc caugaagacc      240

agcagcggcg acccccccag cccccuggug aagcagcuga gcgagguguu cgagaccgag      300

gacagcaaga gcaaccugcc ccccgagccc gugcugcccc ccgaggcccc ccugagcagc      360

gagcuggacc ugccccuggg cacccagcug agcguggagg agcagaugcc ccccuggaac      420

cagaccgagu uccccagcaa gcagguguuc agcaaggagg aggccagaca gcccaccgag      480

acccccgugg ccagccagag cagcgacaag cccagcagag accccgagac ccccagaagc      540

agcggcagca ugagaaacag auggaagccc aacagcagca aggugcuggg cagaagcccc      600

cugaccaucc ugcaggacga caacagcccc ggcacccuga cccugagaca gggcaagaga      660

cccagccccc ugagcgagaa cgugagcgag cugaaggagg gcgccauccu gggcaccggc      720

agacugcuga agaccggcgg cagagccugg gagcagggcc aggaccacga caaggagaac      780

cagcacuucc cccuggugga gagcuga                                          807


<210>  8072
<211>  807
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C8__Homo_sapiens__AAB51327

<400>  8072
augggcagcg ccaaguccgu gcccgucacc ccugcuagac cgcccccuca caacaaacau       60

cuggcccggg uugcggaccc ccgcucuccu agcgcuggga uccucagaac acccauucag      120

guggaguccu cuccucaacc gggacugccc gccggcgaac agcuugaggg gcugaagcac      180

gcccaggaua gcgacccucg gucccccacg cucggaaucg cucgcacccc uaugaaaaca      240

ucuagcggcg aucccccguc cccucuggug aagcagcuua gcgaagucuu cgagaccgaa      300

gacucuaaau ccaaucugcc cccugagccc gugcugcccc cugaggcccc gcucagcucu      360

gaacuggauc ucccccuggg gacacaacuu uccguugagg aacagaugcc ucccuggaac      420

cagaccgagu uuccuagcaa acagguguuc ucuaaggagg aagcuagaca acccacagag      480

accccggucg ccucccagag cuccgacaag ccuucucggg aucccgaaac gccucgcagc      540

uccggaagca ugagaaaucg guggaagccc aacucuucca aagugcuggg ccgcagcccu      600

cucaccauuc ugcaggacga uaauucuccc ggcacacuua cccugagaca ggggaagcgg      660

ccgagcccuc ucuccgagaa cguuucugaa cugaaagagg gagcgauccu gggcacaggg      720

cgccuccuga agaccggagg cagagccugg gagcaagggc aggaccauga uaaggaaaau      780

cagcacuuuc cccuugugga gagcuga                                          807


<210>  8073
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C9__Homo_sapiens__A0A024R035

<400>  8073

Met Ser Ala Cys Trp Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  8074
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8074
augucagccu gcuggagcuu ugcaguugca aucugcauuu uagaaauaag cauccucaca       60

gcacaguaca cgaccaguua ugacccagag cuaacagaaa gcaguggcuc ugcaucacac      120

auagacugca gaaugagccc cuggagugaa uggucacaau gcgauccuug ucucagacaa      180

auguuucguu caagaagcau ugaggucuuu ggacaauuua augggaaaag augcaccgac      240

gcugugggag acagacgaca gugugugccc acagagcccu gugaggaugc ugaggaugac      300

ugcggaaaug acuuucaaug caguacaggc agaugcauaa agaugcgacu ucgguguaau      360

ggugacaaug acugcggaga cuuuucagau gaggaugauu gugaaaguga gccccguccc      420

cccugcagag acagaguggu agaagagucu gagcuggcac gaacagcagg cuaugggauc      480

aacauuuuag ggauggaucc ccuaagcaca ccuuuugaca augaguucua caauggacuc      540

uguaaccggg aucgggaugg aaacacucug acauacuacc gaagaccuug gaacguggcu      600

ucuuugaucu augaaaccaa aggcgagaaa aauuucagaa ccgaacauua cgaagaacaa      660

auugaagcau uuaaaaguau cauccaagag aagacaucaa auuuuaaugc agcuauaucu      720

cuaaaauuua cacccacuga aacaaauaaa gcugaacaau guugugagga aacagccucc      780

ucaauuucuu uacauggcaa ggguaguuuu cgguuuucau auuccaaaaa ugaaacuuac      840

caacuauuuu ugucauauuc uucaaagaag gaaaaaaugu uucugcaugu gaaaggagaa      900

auucaucugg gaagauuugu aaugagaaau cgcgauguug ugcucacaac aacuuuugug      960

gaugauauaa aagcuuugcc aacuaccuau gaaaagggag aauauuuugc cuuuuuggaa     1020

accuauggaa cucacuacag uagcucuggg ucucuaggag gacucuauga acuaauauau     1080

guuuuggaua aagcuuccau gaagcggaaa gguguugaac uaaaagacau aaagagaugc     1140

cuuggguauc aucuggaugu aucucuggcu uucucugaaa ucucuguugg agcugaauuu     1200

aauaaagaug auuguguaaa gaggggagag gguagagcug uaaacaucac cagugaaaac     1260

cucauagaug auguuguuuc acucauaaga gguggaacca gaaaauaugc auuugaacug     1320

aaagaaaagc uucuccgagg aaccgugauu gaugugacug acuuugucaa cugggccucu     1380

uccauaaaug augcuccugu ucucauuagu caaaaacugu cuccuauaua uaaucugguu     1440

ccagugaaaa ugaaaaaugc acaccuaaag aaacaaaacu uggaaagagc cauugaagac     1500

uauaucaaug aauuuagugu aagaaaaugc cacacaugcc aaaauggagg uacagugauu     1560

cuaauggaug gaaaguguuu gugugccugc ccauucaaau uugagggaau ugccugugaa     1620

aucaguaaac aaaaaauuuc ugaaggauug ccagcccuag aguuccccaa ugaaaaauag     1680


<210>  8075
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8075
augagcgccu gcugguccuu cgccguggcg aucugcaucc uggagaucag cauccucacc       60

gcccaguaca ccacguccua cgaccccgag cugaccgaga gcuccggcag cgccucccac      120

aucgacugcc gcaugagccc gugguccgag uggagccagu gcgaccccug ccugcggcag      180

auguuccgcu cccggagcau cgaggucuuc gggcaguuca acggcaagcg cugcaccgac      240

gccguggggg accggcgcca gugcgugccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cuccacgggg cggugcauca agaugcgccu ccggugcaac      360

ggcgacaacg acugcggcga cuucagcgac gaggacgacu gcgaguccga gccgcgcccg      420

cccugccggg accgcgucgu ggaggagagc gagcuggcgc ggaccgccgg guacggcauc      480

aacauccugg ggauggaccc ccucuccacc cccuucgaca acgaguucua caacggccug      540

ugcaaccgcg accgggacgg gaacacccug acguacuacc gccggcccug gaacguggcc      600

agccucaucu acgagaccaa gggcgagaag aacuuccgca ccgagcacua cgaggagcag      660

aucgaggccu ucaaguccau cauccaggag aagaccagca acuucaacgc ggccaucagc      720

cugaaguuca cgcccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccucc      780

agcaucuccc ugcacggcaa ggggagcuuc cgguucuccu acagcaagaa cgagacguac      840

cagcuguucc ucuccuacag cuccaagaag gagaagaugu uccugcacgu caagggcgag      900

auccaccucg ggcgcuucgu gaugcggaac cgcgacgugg uccugaccac caccuucgug      960

gacgacauca aggcccugcc cacgaccuac gagaagggcg aguacuucgc guuccucgag     1020

accuacggca cccacuacag cuccagcggg ucccugggcg ggcuguacga gcucaucuac     1080

gugcuggaca aggccagcau gaagcgcaag ggcgucgagc ugaaggacau caagcggugc     1140

cucggguacc accuggacgu gucccuggcc uucagcgaga ucuccguggg cgccgaguuc     1200

aacaaggacg acugcgucaa gcgcggcgag gggcgggccg ugaacaucac gagcgagaac     1260

cucaucgacg acguggucuc ccugauccgc ggcgggaccc ggaaguacgc guucgagcug     1320

aaggagaagc uccugcgcgg caccgugauc gacgugaccg acuucgucaa cugggccagc     1380

agcaucaacg acgccccggu gcugaucucc cagaagcuca gccccaucua caaccuggug     1440

cccgucaaga ugaagaacgc ccaccugaag aagcagaacc ucgagcgggc caucgaggac     1500

uacaucaacg aguucuccgu gcgcaagugc cacacgugcc agaacggggg caccgucauc     1560

cugauggacg gcaagugccu gugcgcgugc cccuucaagu ucgaggggau cgccugcgag     1620

aucagcaagc agaagaucuc cgagggccuc ccggcccugg aguuccccaa cgagaaguga     1680


<210>  8076
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8076
auguccgccu gcugguccuu cgccgucgcc aucugcaucc ucgagaucuc cauccucacc       60

gcccaguaca ccaccuccua cgaccccgag cucaccgagu ccuccggcuc cgccucccac      120

aucgacugcc gcaugucccc cugguccgag uggucccagu gcgaccccug ccuccgccag      180

auguuccgcu cccgcuccau cgaggucuuc ggccaguuca acggcaagcg cugcaccgac      240

gccgucggcg accgccgcca gugcgucccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cuccaccggc cgcugcauca agaugcgccu ccgcugcaac      360

ggcgacaacg acugcggcga cuucuccgac gaggacgacu gcgaguccga gccccgcccc      420

cccugccgcg accgcgucgu cgaggagucc gagcucgccc gcaccgccgg cuacggcauc      480

aacauccucg gcauggaccc ccucuccacc cccuucgaca acgaguucua caacggccuc      540

ugcaaccgcg accgcgacgg caacacccuc accuacuacc gccgccccug gaacgucgcc      600

ucccucaucu acgagaccaa gggcgagaag aacuuccgca ccgagcacua cgaggagcag      660

aucgaggccu ucaaguccau cauccaggag aagaccucca acuucaacgc cgccaucucc      720

cucaaguuca cccccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccucc      780

uccaucuccc uccacggcaa gggcuccuuc cgcuucuccu acuccaagaa cgagaccuac      840

cagcucuucc ucuccuacuc cuccaagaag gagaagaugu uccuccacgu caagggcgag      900

auccaccucg gccgcuucgu caugcgcaac cgcgacgucg uccucaccac caccuucguc      960

gacgacauca aggcccuccc caccaccuac gagaagggcg aguacuucgc cuuccucgag     1020

accuacggca cccacuacuc cuccuccggc ucccucggcg gccucuacga gcucaucuac     1080

guccucgaca aggccuccau gaagcgcaag ggcgucgagc ucaaggacau caagcgcugc     1140

cucggcuacc accucgacgu cucccucgcc uucuccgaga ucuccgucgg cgccgaguuc     1200

aacaaggacg acugcgucaa gcgcggcgag ggccgcgccg ucaacaucac cuccgagaac     1260

cucaucgacg acgucgucuc ccucauccgc ggcggcaccc gcaaguacgc cuucgagcuc     1320

aaggagaagc uccuccgcgg caccgucauc gacgucaccg acuucgucaa cugggccucc     1380

uccaucaacg acgcccccgu ccucaucucc cagaagcucu cccccaucua caaccucguc     1440

cccgucaaga ugaagaacgc ccaccucaag aagcagaacc ucgagcgcgc caucgaggac     1500

uacaucaacg aguucuccgu ccgcaagugc cacaccugcc agaacggcgg caccgucauc     1560

cucauggacg gcaagugccu cugcgccugc cccuucaagu ucgagggcau cgccugcgag     1620

aucuccaagc agaagaucuc cgagggccuc cccgcccucg aguuccccaa cgagaaguga     1680


<210>  8077
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8077
augagcgccu gcugguccuu cgcuguggca aucuguauuc uggagauauc uauccucacc       60

gcccaauaca caacuucaua ugaccccgaa cuuacggaga guagcggcuc cgcgucucac      120

auugauugca gaaugucgcc uuggucagaa uggagccaau gugacccaug ccugaggcag      180

auguuucgga gucgcuccau cgaggucuuc gggcaguuua acggaaagcg auguaccgau      240

gcuguuggug accguagaca gugcgugccg acagaacccu gugaggaugc cgaggacgau      300

ugcggcaaug acuuccaaug uucuacuggg aggugcauua aaaugcgguu gcgcuguaac      360

ggagauaaug acugcggcga uuuuagcgac gaagaugacu gcgaguccga accuagacca      420

cccuguaggg accggguagu ggaggaguca gaauuagcac gcaccgccgg uuacgggauc      480

aacauacugg gaauggaucc ucuaaguaca ccauucgaca augaguuuua uaacggccuc      540

ugcaaucgag auagagacgg caacacccug acuuacuaua ggcggcccug gaaugucgcu      600

agccuuaucu acgaaacaaa gggggagaaa aacuuccgua ccgaacauua ugaggagcag      660

auugaagcau uuaagucuau cauucaggag aaaacgucca auuucaacgc cgcuaucuca      720

cugaaguuua cuccuaccga aacaaauaag gccgagcagu guugcgaaga gacugcgagc      780

aguauaucuu ugcacggaaa agguuccuuc cgcuuuagcu acucgaagaa cgagaccuac      840

caacucuucc ugucuuauuc caguaaaaag gagaaaaugu uccugcaugu gaagggcgaa      900

auucaccucg ggagauuugu uaugaggaau cgggaugugg ucuuaacaac cacguucgug      960

gacgauauca aggcacugcc aacuacauac gaaaaaggag aguauuuugc cuuccuugaa     1020

accuacggca cucauuauuc aagcuccggu ucuuugggag ggcuguacga gcuaauuuau     1080

guacucgaca aggcuagcau gaaacgaaag ggcguugagc ugaaagauau caagcgcugu     1140

cuuggcuacc accuggacgu gucauuggcc uuuagugaaa ucuccgucgg ggcagaguuc     1200

aacaaagaug acugcgugaa gagaggagaa gguagggcug ugaacauuac aagcgagaau     1260

cucauagacg augucguuuc ucugauccgg ggcgggaccc gcaaguacgc cuuugaguua     1320

aaagaaaagc ugcucagagg aacggugauu gacguaaccg auuucgugaa cugggcguca     1380

aguaucaaug acgccccggu ccuuauaagc cagaaacugu cccccauuua uaacuuggug     1440

ccuguuaaga ugaaaaaugc acaccuaaag aagcagaacc uggagagggc uaucgaagau     1500

uacaucaaug aguuuucugu gcguaaaugu cauacaugcc agaacggcgg uacugucauu     1560

cucauggacg ggaagugucu gugcgccugu ccauucaaau uugaaggcau cgcuugcgag     1620

auuucgaagc agaaaauaag cgagggacuu cccgcccugg aguucccuaa ugaaaaguga     1680


<210>  8078
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8078
augagcgccu gcuggagcuu cgccguggcc aucugcaucc uggagaucag cauccugacc       60

gcccaguaca ccaccagcua cgaccccgag cugaccgaga gcagcggcag cgccagccac      120

aucgacugca gaaugagccc cuggagcgag uggagccagu gcgaccccug ccugagacag      180

auguucagaa gcagaagcau cgagguguuc ggccaguuca acggcaagag augcaccgac      240

gccgugggcg acagaagaca gugcgugccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cagcaccggc agaugcauca agaugagacu gagaugcaac      360

ggcgacaacg acugcggcga cuucagcgac gaggacgacu gcgagagcga gcccagaccc      420

cccugcagag acagaguggu ggaggagagc gagcuggcca gaaccgccgg cuacggcauc      480

aacauccugg gcauggaccc ccugagcacc cccuucgaca acgaguucua caacggccug      540

ugcaacagag acagagacgg caacacccug accuacuaca gaagacccug gaacguggcc      600

agccugaucu acgagaccaa gggcgagaag aacuucagaa ccgagcacua cgaggagcag      660

aucgaggccu ucaagagcau cauccaggag aagaccagca acuucaacgc cgccaucagc      720

cugaaguuca cccccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccagc      780

agcaucagcc ugcacggcaa gggcagcuuc agauucagcu acagcaagaa cgagaccuac      840

cagcuguucc ugagcuacag cagcaagaag gagaagaugu uccugcacgu gaagggcgag      900

auccaccugg gcagauucgu gaugagaaac agagacgugg ugcugaccac caccuucgug      960

gacgacauca aggcccugcc caccaccuac gagaagggcg aguacuucgc cuuccuggag     1020

accuacggca cccacuacag cagcagcggc agccugggcg gccuguacga gcugaucuac     1080

gugcuggaca aggccagcau gaagagaaag ggcguggagc ugaaggacau caagagaugc     1140

cugggcuacc accuggacgu gagccuggcc uucagcgaga ucagcguggg cgccgaguuc     1200

aacaaggacg acugcgugaa gagaggcgag ggcagagccg ugaacaucac cagcgagaac     1260

cugaucgacg acguggugag ccugaucaga ggcggcacca gaaaguacgc cuucgagcug     1320

aaggagaagc ugcugagagg caccgugauc gacgugaccg acuucgugaa cugggccagc     1380

agcaucaacg acgcccccgu gcugaucagc cagaagcuga gccccaucua caaccuggug     1440

cccgugaaga ugaagaacgc ccaccugaag aagcagaacc uggagagagc caucgaggac     1500

uacaucaacg aguucagcgu gagaaagugc cacaccugcc agaacggcgg caccgugauc     1560

cugauggacg gcaagugccu gugcgccugc cccuucaagu ucgagggcau cgccugcgag     1620

aucagcaagc agaagaucag cgagggccug cccgcccugg aguuccccaa cgagaaguga     1680


<210>  8079
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C9__Homo_sapiens__EAW55986

<400>  8079
augagcgccu gcugguccuu cgcuguggcc aucuguauuc uggagaucuc uauucucacc       60

gcgcaauaca caacgagcua ugaccccgaa cugaccgagu ccucuggcag cgcuucccac      120

aucgauugca gaaugucucc uuggagcgaa uggucccaau gugacccgug ccuucggcag      180

auguuucgca gcagaucuau ugaggucuuc gggcaguuua acggaaagcg guguacagau      240

gccguuggcg accgcagaca gugcgugccc accgaaccuu gugaggaugc cgaggacgau      300

ugcgggaaug acuuccaaug uuccacagga cggugcauca aaaugcgccu gagauguaac      360

ggcgauaaug acugcgggga uuuuagcgac gaagaugacu gcgagucuga accccggccu      420

cccugucgcg acagaguggu cgaggagucc gaacucgcuc ggaccgccgg auacggcauc      480

aacauucugg gcauggaucc ucuuagcaca ccguucgaca augaguuuua uaacgggcug      540

ugcaaucgcg auagagacgg aaacacccuc acguacuauc ggcgccccug gaauguggcu      600

ucucugaucu acgaaaccaa gggcgagaaa aacuucagaa cagaacauua ugaggagcag      660

auugaagccu uuaaguccau cauucaggag aaaaccagca auuucaacgc ggccaucucc      720

cugaaguuua caccuaccga aacgaauaag gcugagcagu guugcgaaga gacagccucu      780

agcauuuccc uccacgggaa aggcagcuuc cgguuuucuu acuccaagaa cgagaccuac      840

caacuguucc uuagcuauuc uagcaaaaag gagaaaaugu uccugcaugu uaagggagaa      900

auccaccucg ggagauuugu gaugcgcaau cgggaugucg ugcugacaac caccuucguu      960

gacgauauca aggcccuucc cacaacguac gaaaaaggag aguauuuugc uuuccuggaa     1020

accuacggca cacauuauuc cucuagcggc ucccucgggg gacuguacga gcugauuuau     1080

gugcucgaca aggcgagcau gaaaagaaag ggcgucgagc ugaaagauau caagcgcugu     1140

cuuggguacc accuggacgu gucucucgcc uuuuccgaaa uuagcguggg agcugaguuc     1200

aacaaagaug acugcgucaa gcggggcgaa gggagagccg uuaacaucac cucugagaau     1260

cugauugacg augugguguc ccuuauccgc ggaggcacac ggaaguacgc uuuugagcug     1320

aaagaaaagc uccugagagg caccgucauc gacgugacgg auuucguuaa cugggccagc     1380

uccauuaaug acgccccugu gcugaucucu cagaaacuca gccccauuua uaaccugguc     1440

ccggugaaga ugaaaaaugc ucaccuuaag aagcagaacc uggagcgcgc gaucgaagau     1500

uacauuaaug aguuuuccgu ucggaaaugu cauacaugcc agaacggggg aaccgugauc     1560

cucauggacg gcaagugucu gugcgccugu ccuuucaaau uugaagggau cgcuugcgag     1620

auuucuaagc agaaaaucag cgagggacuu cccgcccugg aguucccuaa ugaaaaguga     1680


<210>  8080
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C9__Homo_sapiens__P02748

<400>  8080

Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  8081
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8081
augucagccu gccggagcuu ugcaguugca aucugcauuu uagaaauaag cauccucaca       60

gcacaguaca cgaccaguua ugacccagag cuaacagaaa gcaguggcuc ugcaucacac      120

auagacugca gaaugagccc cuggagugaa uggucacaau gcgauccuug ucucagacaa      180

auguuucguu caagaagcau ugaggucuuu ggacaauuua augggaaaag augcaccgac      240

gcugugggag acagacgaca gugugugccc acagagcccu gugaggaugc ugaggaugac      300

ugcggaaaug acuuucaaug caguacaggc agaugcauaa agaugcgacu ucgguguaau      360

ggugacaaug acugcggaga cuuuucagau gaggaugauu gugaaaguga gccccguccc      420

cccugcagag acagaguggu agaagagucu gagcuggcac gaacagcagg cuaugggauc      480

aacauuuuag ggauggaucc ccuaagcaca ccuuuugaca augaguucua caauggacuc      540

uguaaccggg aucgggaugg aaacacucug acauacuacc gaagaccuug gaacguggcu      600

ucuuugaucu augaaaccaa aggcgagaaa aauuucagaa ccgaacauua cgaagaacaa      660

auugaagcau uuaaaaguau cauccaagag aagacaucaa auuuuaaugc agcuauaucu      720

cuaaaauuua cacccacuga aacaaauaaa gcugaacaau guugugagga aacagccucc      780

ucaauuucuu uacauggcaa ggguaguuuu cgguuuucau auuccaaaaa ugaaacuuac      840

caacuauuuu ugucauauuc uucaaagaag gaaaaaaugu uucugcaugu gaaaggagaa      900

auucaucugg gaagauuugu aaugagaaau cgcgauguug ugcucacaac aacuuuugug      960

gaugauauaa aagcuuugcc aacuaccuau gaaaagggag aauauuuugc cuuuuuggaa     1020

accuauggaa cucacuacag uagcucuggg ucucuaggag gacucuauga acuaauauau     1080

guuuuggaua aagcuuccau gaagcggaaa gguguugaac uaaaagacau aaagagaugc     1140

cuuggguauc aucuggaugu aucucuggcu uucucugaaa ucucuguugg agcugaauuu     1200

aauaaagaug auuguguaaa gaggggagag gguagagcug uaaacaucac cagugaaaac     1260

cucauagaug auguuguuuc acucauaaga gguggaacca gaaaauaugc auuugaacug     1320

aaagaaaagc uucuccgagg aaccgugauu gaugugacug acuuugucaa cugggccucu     1380

uccauaaaug augcuccugu ucucauuagu caaaaacugu cuccuauaua uaaucugguu     1440

ccagugaaaa ugaaaaaugc acaccuaaag aaacaaaacu uggaaagagc cauugaagac     1500

uauaucaaug aauuuagugu aagaaaaugc cacacaugcc aaaauggagg uacagugauu     1560

cuaauggaug gaaaguguuu gugugccugc ccauucaaau uugagggaau ugccugugaa     1620

aucaguaaac aaaaaauuuc ugaaggauug ccagcccuag aguuccccaa ugaaaaauag     1680


<210>  8082
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8082
augagcgccu gccgcuccuu cgccguggcg aucugcaucc uggagaucag cauccucacc       60

gcccaguaca ccacguccua cgaccccgag cugaccgaga gcuccggcag cgccucccac      120

aucgacugcc ggaugagccc gugguccgag uggagccagu gcgaccccug ccugcgccag      180

auguuccggu cccgcagcau cgaggucuuc gggcaguuca acggcaagcg gugcaccgac      240

gccguggggg accgccggca gugcgugccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cuccacgggg cgcugcauca agaugcggcu ccgcugcaac      360

ggcgacaacg acugcggcga cuucagcgac gaggacgacu gcgaguccga gccgcggccg      420

cccugccgcg accgggucgu ggaggagagc gagcuggcgc gcaccgccgg guacggcauc      480

aacauccugg ggauggaccc ccucuccacc cccuucgaca acgaguucua caacggccug      540

ugcaaccggg accgcgacgg gaacacccug acguacuacc ggcgccccug gaacguggcc      600

agccucaucu acgagaccaa gggcgagaag aacuuccgga ccgagcacua cgaggagcag      660

aucgaggccu ucaaguccau cauccaggag aagaccagca acuucaacgc ggccaucagc      720

cugaaguuca cgcccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccucc      780

agcaucuccc ugcacggcaa ggggagcuuc cgcuucuccu acagcaagaa cgagacguac      840

cagcuguucc ucuccuacag cuccaagaag gagaagaugu uccugcacgu caagggcgag      900

auccaccucg ggcgguucgu gaugcgcaac cgcgacgugg uccugaccac caccuucgug      960

gacgacauca aggcccugcc cacgaccuac gagaagggcg aguacuucgc guuccucgag     1020

accuacggca cccacuacag cuccagcggg ucccugggcg ggcuguacga gcucaucuac     1080

gugcuggaca aggccagcau gaagcggaag ggcgucgagc ugaaggacau caagcgcugc     1140

cucggguacc accuggacgu gucccuggcc uucagcgaga ucuccguggg cgccgaguuc     1200

aacaaggacg acugcgucaa gcggggcgag gggcgcgccg ugaacaucac gagcgagaac     1260

cucaucgacg acguggucuc ccugauccgg ggcgggaccc gcaaguacgc guucgagcug     1320

aaggagaagc uccugcgggg caccgugauc gacgugaccg acuucgucaa cugggccagc     1380

agcaucaacg acgccccggu gcugaucucc cagaagcuca gccccaucua caaccuggug     1440

cccgucaaga ugaagaacgc ccaccugaag aagcagaacc ucgagcgcgc caucgaggac     1500

uacaucaacg aguucuccgu gcggaagugc cacacgugcc agaacggggg caccgucauc     1560

cugauggacg gcaagugccu gugcgcgugc cccuucaagu ucgaggggau cgccugcgag     1620

aucagcaagc agaagaucuc cgagggccuc ccggcccugg aguuccccaa cgagaaguga     1680


<210>  8083
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8083
auguccgccu gccgcuccuu cgccgucgcc aucugcaucc ucgagaucuc cauccucacc       60

gcccaguaca ccaccuccua cgaccccgag cucaccgagu ccuccggcuc cgccucccac      120

aucgacugcc gcaugucccc cugguccgag uggucccagu gcgaccccug ccuccgccag      180

auguuccgcu cccgcuccau cgaggucuuc ggccaguuca acggcaagcg cugcaccgac      240

gccgucggcg accgccgcca gugcgucccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cuccaccggc cgcugcauca agaugcgccu ccgcugcaac      360

ggcgacaacg acugcggcga cuucuccgac gaggacgacu gcgaguccga gccccgcccc      420

cccugccgcg accgcgucgu cgaggagucc gagcucgccc gcaccgccgg cuacggcauc      480

aacauccucg gcauggaccc ccucuccacc cccuucgaca acgaguucua caacggccuc      540

ugcaaccgcg accgcgacgg caacacccuc accuacuacc gccgccccug gaacgucgcc      600

ucccucaucu acgagaccaa gggcgagaag aacuuccgca ccgagcacua cgaggagcag      660

aucgaggccu ucaaguccau cauccaggag aagaccucca acuucaacgc cgccaucucc      720

cucaaguuca cccccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccucc      780

uccaucuccc uccacggcaa gggcuccuuc cgcuucuccu acuccaagaa cgagaccuac      840

cagcucuucc ucuccuacuc cuccaagaag gagaagaugu uccuccacgu caagggcgag      900

auccaccucg gccgcuucgu caugcgcaac cgcgacgucg uccucaccac caccuucguc      960

gacgacauca aggcccuccc caccaccuac gagaagggcg aguacuucgc cuuccucgag     1020

accuacggca cccacuacuc cuccuccggc ucccucggcg gccucuacga gcucaucuac     1080

guccucgaca aggccuccau gaagcgcaag ggcgucgagc ucaaggacau caagcgcugc     1140

cucggcuacc accucgacgu cucccucgcc uucuccgaga ucuccgucgg cgccgaguuc     1200

aacaaggacg acugcgucaa gcgcggcgag ggccgcgccg ucaacaucac cuccgagaac     1260

cucaucgacg acgucgucuc ccucauccgc ggcggcaccc gcaaguacgc cuucgagcuc     1320

aaggagaagc uccuccgcgg caccgucauc gacgucaccg acuucgucaa cugggccucc     1380

uccaucaacg acgcccccgu ccucaucucc cagaagcucu cccccaucua caaccucguc     1440

cccgucaaga ugaagaacgc ccaccucaag aagcagaacc ucgagcgcgc caucgaggac     1500

uacaucaacg aguucuccgu ccgcaagugc cacaccugcc agaacggcgg caccgucauc     1560

cucauggacg gcaagugccu cugcgccugc cccuucaagu ucgagggcau cgccugcgag     1620

aucuccaagc agaagaucuc cgagggccuc cccgcccucg aguuccccaa cgagaaguga     1680


<210>  8084
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8084
augagcgccu gcagauccuu cgcuguggca aucuguauuc uggagauauc uauccucacc       60

gcccaauaca caacuucaua ugaccccgaa cuuacggaga guagcggcuc cgcgucucac      120

auugauugca ggaugucgcc uuggucagaa uggagccaau gugacccaug ccugcggcag      180

auguuucgca gucgauccau cgaggucuuc gggcaguuua acggaaagcg uuguaccgau      240

gcuguuggug acagaaggca gugcgugccg acagaacccu gugaggaugc cgaggacgau      300

ugcggcaaug acuuccaaug uucuacuggg cggugcauua aaaugcgcuu gagauguaac      360

ggagauaaug acugcggcga uuuuagcgac gaagaugacu gcgaguccga accuaggcca      420

cccugucggg accgcguagu ggaggaguca gaauuagcac gaaccgccgg uuacgggauc      480

aacauacugg gaauggaucc ucuaaguaca ccauucgaca augaguuuua uaacggccuc      540

ugcaauagag auagggacgg caacacccug acuuacuauc ggcgucccug gaaugucgcu      600

agccuuaucu acgaaacaaa gggggagaaa aacuuccgca ccgaacauua ugaggagcag      660

auugaagcau uuaagucuau cauucaggag aaaacgucca auuucaacgc cgcuaucuca      720

cugaaguuua cuccuaccga aacaaauaag gccgagcagu guugcgaaga gacugcgagc      780

aguauaucuu ugcacggaaa agguuccuuc agauuuagcu acucgaagaa cgagaccuac      840

caacucuucc ugucuuauuc caguaaaaag gagaaaaugu uccugcaugu gaagggcgaa      900

auucaccucg ggagguuugu uaugcggaau cgagaugugg ucuuaacaac cacguucgug      960

gacgauauca aggcacugcc aacuacauac gaaaaaggag aguauuuugc cuuccuugaa     1020

accuacggca cucauuauuc aagcuccggu ucuuugggag ggcuguacga gcuaauuuau     1080

guacucgaca aggcuagcau gaaacgcaag ggcguugagc ugaaagauau caagagaugu     1140

cuuggcuacc accuggacgu gucauuggcc uuuagugaaa ucuccgucgg ggcagaguuc     1200

aacaaagaug acugcgugaa gaggggagaa ggucgggcug ugaacauuac aagcgagaau     1260

cucauagacg augucguuuc ucugauccgc ggcgggacca gaaaguacgc cuuugaguua     1320

aaagaaaagc ugcucagggg aacggugauu gacguaaccg auuucgugaa cugggcguca     1380

aguaucaaug acgccccggu ccuuauaagc cagaaacugu cccccauuua uaacuuggug     1440

ccuguuaaga ugaaaaaugc acaccuaaag aagcagaacc uggagcgugc uaucgaagau     1500

uacaucaaug aguuuucugu gcggaaaugu cauacaugcc agaacggcgg uacugucauu     1560

cucauggacg ggaagugucu gugcgccugu ccauucaaau uugaaggcau cgcuugcgag     1620

auuucgaagc agaaaauaag cgagggacuu cccgcccugg aguucccuaa ugaaaaguga     1680


<210>  8085
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8085
augagcgccu gcagaagcuu cgccguggcc aucugcaucc uggagaucag cauccugacc       60

gcccaguaca ccaccagcua cgaccccgag cugaccgaga gcagcggcag cgccagccac      120

aucgacugca gaaugagccc cuggagcgag uggagccagu gcgaccccug ccugagacag      180

auguucagaa gcagaagcau cgagguguuc ggccaguuca acggcaagag augcaccgac      240

gccgugggcg acagaagaca gugcgugccc accgagcccu gcgaggacgc cgaggacgac      300

ugcggcaacg acuuccagug cagcaccggc agaugcauca agaugagacu gagaugcaac      360

ggcgacaacg acugcggcga cuucagcgac gaggacgacu gcgagagcga gcccagaccc      420

cccugcagag acagaguggu ggaggagagc gagcuggcca gaaccgccgg cuacggcauc      480

aacauccugg gcauggaccc ccugagcacc cccuucgaca acgaguucua caacggccug      540

ugcaacagag acagagacgg caacacccug accuacuaca gaagacccug gaacguggcc      600

agccugaucu acgagaccaa gggcgagaag aacuucagaa ccgagcacua cgaggagcag      660

aucgaggccu ucaagagcau cauccaggag aagaccagca acuucaacgc cgccaucagc      720

cugaaguuca cccccaccga gaccaacaag gccgagcagu gcugcgagga gaccgccagc      780

agcaucagcc ugcacggcaa gggcagcuuc agauucagcu acagcaagaa cgagaccuac      840

cagcuguucc ugagcuacag cagcaagaag gagaagaugu uccugcacgu gaagggcgag      900

auccaccugg gcagauucgu gaugagaaac agagacgugg ugcugaccac caccuucgug      960

gacgacauca aggcccugcc caccaccuac gagaagggcg aguacuucgc cuuccuggag     1020

accuacggca cccacuacag cagcagcggc agccugggcg gccuguacga gcugaucuac     1080

gugcuggaca aggccagcau gaagagaaag ggcguggagc ugaaggacau caagagaugc     1140

cugggcuacc accuggacgu gagccuggcc uucagcgaga ucagcguggg cgccgaguuc     1200

aacaaggacg acugcgugaa gagaggcgag ggcagagccg ugaacaucac cagcgagaac     1260

cugaucgacg acguggugag ccugaucaga ggcggcacca gaaaguacgc cuucgagcug     1320

aaggagaagc ugcugagagg caccgugauc gacgugaccg acuucgugaa cugggccagc     1380

agcaucaacg acgcccccgu gcugaucagc cagaagcuga gccccaucua caaccuggug     1440

cccgugaaga ugaagaacgc ccaccugaag aagcagaacc uggagagagc caucgaggac     1500

uacaucaacg aguucagcgu gagaaagugc cacaccugcc agaacggcgg caccgugauc     1560

cugauggacg gcaagugccu gugcgccugc cccuucaagu ucgagggcau cgccugcgag     1620

aucagcaagc agaagaucag cgagggccug cccgcccugg aguuccccaa cgagaaguga     1680


<210>  8086
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_C9__Homo_sapiens__AAH20721

<400>  8086
augagcgccu gcagauccuu cgcuguggcc aucuguauuc uggagaucuc uauucucacc       60

gcgcaauaca caacgagcua ugaccccgaa cugaccgagu ccucuggcag cgcuucccac      120

aucgauugcc ggaugucucc uuggagcgaa uggucccaau gugacccgug ccuucgccag      180

auguuuagaa gccggucuau ugaggucuuc gggcaguuua acggaaagcg cuguacagau      240

gccguuggcg acagacggca gugcgugccc accgaaccuu gugaggaugc cgaggacgau      300

ugcgggaaug acuuccaaug uuccacagga cgcugcauca aaaugagacu gcgguguaac      360

ggcgauaaug acugcgggga uuuuagcgac gaagaugacu gcgagucuga accccgcccu      420

cccuguagag accggguggu cgaggagucc gaacucgcuc gcaccgccgg auacggcauc      480

aacauucugg gcauggaucc ucuuagcaca ccguucgaca augaguuuua uaacgggcug      540

ugcaauagag aucgggacgg aaacacccuc acguacuauc gcagacccug gaauguggcu      600

ucucugaucu acgaaaccaa gggcgagaaa aacuuccgga cagaacauua ugaggagcag      660

auugaagccu uuaaguccau cauucaggag aaaaccagca auuucaacgc ggccaucucc      720

cugaaguuua caccuaccga aacgaauaag gcugagcagu guugcgaaga gacagccucu      780

agcauuuccc uccacgggaa aggcagcuuc agauuuucuu acuccaagaa cgagaccuac      840

caacuguucc uuagcuauuc uagcaaaaag gagaaaaugu uccugcaugu uaagggagaa      900

auccaccucg ggcgcuuugu gaugcggaau agagaugucg ugcugacaac caccuucguu      960

gacgauauca aggcccuucc cacaacguac gaaaaaggag aguauuuugc uuuccuggaa     1020

accuacggca cacauuauuc cucuagcggc ucccucgggg gacuguacga gcugauuuau     1080

gugcucgaca aggcgagcau gaaacgcaag ggcgucgagc ugaaagauau caagcggugu     1140

cuuggguacc accuggacgu gucucucgcc uuuuccgaaa uuagcguggg agcugaguuc     1200

aacaaagaug acugcgucaa gagaggcgaa gggcgcgccg uuaacaucac cucugagaau     1260

cugauugacg augugguguc ccuuauccgg ggaggcacaa gaaaguacgc uuuugagcug     1320

aaagaaaagc uccugcgcgg caccgucauc gacgugacgg auuucguuaa cugggccagc     1380

uccauuaaug acgccccugu gcugaucucu cagaaacuca gccccauuua uaaccugguc     1440

ccggugaaga ugaaaaaugc ucaccuuaag aagcagaacc uggagcgggc gaucgaagau     1500

uacauuaaug aguuuuccgu uagaaaaugu cauacaugcc agaacggggg aaccgugauc     1560

cucauggacg gcaagugucu gugcgccugu ccuuucaaau uugaagggau cgcuugcgag     1620

auuucuaagc agaaaaucag cgagggacuu cccgcccugg aguucccuaa ugaaaaguga     1680


<210>  8087
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR2__Homo_sapiens__P20023

<400>  8087

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Thr Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Thr Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Thr Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe 
            740                 745                 750         


Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly 
        755                 760                 765             


His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro 
    770                 775                 780                 


Val Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn 
785                 790                 795                 800 


Lys Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys 
                805                 810                 815     


Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Thr 
            820                 825                 830         


Asp Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe 
        835                 840                 845             


Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly 
    850                 855                 860                 


Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys 
865                 870                 875                 880 


Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His 
                885                 890                 895     


Glu Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys 
            900                 905                 910         


Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg 
        915                 920                 925             


Lys Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly 
    930                 935                 940                 


Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln 
945                 950                 955                 960 


Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val 
                965                 970                 975     


Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val 
            980                 985                 990         


Ile Thr Leu Tyr Val Ile Ser Lys His Arg Ala Arg Asn Tyr Tyr Thr 
        995                 1000                1005            


Asp Thr Ser Gln Lys Glu Ala Phe His Leu Glu Ala Arg Glu Val Tyr 
    1010                1015                1020                


Ser Val Asp Pro Tyr Asn Pro Ala Ser 
1025                1030            


<210>  8088
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8088
augggcgccg cgggccugcu cgggguuuuc uuggcucucg ucgcaccggg gguccucggg       60

auuucuugug gcucuccucc gccuauccua aauggccgga uuaguuauua uucuaccccc      120

auugcuguug guaccgugau aagguacagu uguucaggua ccuuccgccu cauuggagaa      180

aaaagucuau uaugcauaac uaaagacaaa guggauggaa ccugggauaa accugcuccu      240

aaaugugaau auuucaauaa auauucuucu ugcccugagc ccauaguacc aggaggauac      300

aaaauuagag gcucuacacc cuacagacau ggugauucug ugacauuugc cuguaaaacc      360

aacuucucca ugaacggaaa caagucuguu uggugucaag caaauaauau gugggggccg      420

acacgacuac caaccugugu aaguguuuuc ccucucgagu guccagcacu uccuaugauc      480

cacaauggac aucacacaag ugagaauguu ggcuccauug cuccaggauu gucugugacu      540

uacagcugug aaucugguua cuugcuuguu ggagaaaaga ucauuaacug uuugucuucg      600

ggaaaaugga gugcuguccc ccccacaugu gaagaggcac gcuguaaauc ucuaggacga      660

uuucccaaug ggaagguaaa ggagccucca auucuccggg uugguguaac ugcaaacuuu      720

uucugugaug aaggguaucg acugcaaggc ccaccuucua gucggugugu aauugcugga      780

cagggaguug cuuggaccaa aaugccagua ugugaagaaa uuuuuugccc aucaccuccc      840

ccuauucuca auggaagaca uauaggcaac ucacuagcaa augucucaua uggaagcaua      900

gucacuuaca cuugugaccc ggacccagag gaaggaguga acuucauccu uauuggagag      960

agcacucucc guuguacagu ugauagucag aagacuggga ccuggagugg cccugcccca     1020

cgcugugaac uuucuacuuc ugcgguucag uguccacauc cccagauccu aagaggccga     1080

augguaucug ggcagaaaga ucgauauacc uauaacgaca cugugauauu ugcuugcaug     1140

uuuggcuuca ccuugaaggg cagcaagcaa auccgaugca augcccaagg cacaugggag     1200

ccaucugcac cagucuguga aaaggaaugc caggccccuc cuaacauccu caaugggcaa     1260

aaggaagaua gacacauggu ccgcuuugac ccuggaacau cuauaaaaua uagcuguaac     1320

ccuggcuaug ugcugguggg agaagaaucc auacagugua ccucugaggg gguguggaca     1380

cccccuguac cccaaugcaa aguggcagcg ugugaagcua caggaaggca acucuugaca     1440

aaaccccagc accaauuugu uagaccagau gucaacucuu cuugugguga aggguacaag     1500

uuaaguggga guguuuauca ggagugucaa ggcacaauuc cuugguuuau ggagauucgu     1560

cuuuguaaag aaaucaccug cccaccaccc ccuguuaucu acaauggggc acacaccggg     1620

aguuccuuag aagauuuucc auauggaacc acggucacuu acacauguaa cccugggcca     1680

gaaagaggag uggaauucag ccucauugga gagagcacca uccguuguac aagcaaugau     1740

caagaaagag gcaccuggag uggcccugcu ccccugugua aacuuucccu ccuugcuguc     1800

cagugcucac auguccauau ugcaaaugga uacaagauau cuggcaagga agccccauau     1860

uucuacaaug acacugugac auucaagugu uauaguggau uuacuuugaa gggcaguagu     1920

cagauucguu gcaaagcuga uaacaccugg gauccugaaa uaccaguuug ugaaaaagaa     1980

acaugccagc augugagaca gagucuucaa gaacuuccag cugguucacg uguggagcua     2040

guuaauacgu ccugccaaga uggguaccag uugacuggac augcuuauca gaugugucaa     2100

gaugcugaaa auggaauuug guucaaaaag auuccacuuu guaaaguuau ucacugucac     2160

ccuccaccag ugauugucaa ugggaagcac acaggcauga uggcagaaaa cuuucuauau     2220

ggaaaugaag ucucuuauga augugaccaa ggauucuauc uccugggaga gaaaaaauug     2280

cagugcagaa gugauucuaa aggacaugga ucuuggagcg ggccuucccc acagugcuua     2340

cgaucuccuc cugugacucg cugcccuaau ccagaaguca aacaugggua caagcucaau     2400

aaaacacauu cugcauauuc ccacaaugac auaguguaug uugacugcaa uccuggcuuc     2460

aucaugaaug guagucgcgu gauuaggugu cauacugaua acacaugggu gccaggugug     2520

ccaacuugua ucaaaaaagc cuucauaggg uguccaccuc cgccuaagac cccuaacggg     2580

aaccauacug guggaaacau agcucgauuu ucuccuggaa ugucaauccu guacagcugu     2640

gaccaaggcu accugcuggu gggagaggca cuccuucuuu gcacacauga gggaaccugg     2700

agccaaccug ccccucauug uaaagaggua aacuguagcu caccagcaga uauggaugga     2760

auccagaaag ggcuggaacc aaggaaaaug uaucaguaug gagcuguugu aacucuggag     2820

ugugaagaug gguauaugcu ggaaggcagu ccccagagcc agugccaauc ggaucaccaa     2880

uggaacccuc cccuggcggu uugcagaucc cguucacuug cuccuguccu uugugguauu     2940

gcugcagguu ugauacuucu uaccuucuug auugucauua ccuuauacgu gauaucaaaa     3000

cacagagcac gcaauuauua uacagauaca agccagaaag aagcuuuuca uuuagaagca     3060

cgagaaguau auucuguuga uccauacaac ccagccagcu ga                        3102


<210>  8089
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8089
augggcgccg ccgggcugcu cggcguguuc cuggcgcugg ucgcccccgg ggugcucggc       60

aucagcugcg gguccccgcc ccccauccug aacggccgca ucagcuacua cuccaccccc      120

aucgccgugg gcaccgucau ccgguacagc ugcuccggga cguuccgccu gaucggcgag      180

aagagccucc ugugcaucac caaggacaag guggacggga ccugggacaa gccggccccc      240

aagugcgagu acuucaacaa guacuccagc ugccccgagc ccaucgugcc gggcggguac      300

aagauccggg gcuccacccc cuaccgccac ggcgacagcg ucacguucgc cugcaagacc      360

aacuucucca ugaacgggaa caagagcgug uggugccagg cgaacaacau guggggcccc      420

acccggcugc ccaccugcgu guccgucuuc ccgcucgagu gccccgcccu gcccaugauc      480

cacaacgggc accacacgag cgagaacgug ggcuccaucg cccccggccu gagcgugacc      540

uacuccugcg agagcgggua ccuccugguc ggcgagaaga ucaucaacug ccuguccagc      600

gggaagugga gcgccgugcc gcccaccugc gaggaggcgc gcugcaaguc ccucggccgg      660

uuccccaacg ggaaggugaa ggagcccccg auccugcgcg ucggcgugac cgccaacuuc      720

uucugcgacg agggcuaccg gcugcagggg ccccccagcu cccgcugcgu gaucgccggc      780

cagggggucg ccuggacgaa gaugcccgug ugcgaggaga ucuucugccc gagccccccc      840

cccauccuca acggccggca caucgggaac ucccuggcca acgugagcua cggcuccauc      900

gucaccuaca ccugcgaccc ggaccccgag gagggcguga acuucauccu gaucggggag      960

agcacccucc gcugcacggu ggacucccag aagaccggca ccuggagcgg gcccgcgccg     1020

cggugcgagc uguccaccag cgccguccag ugcccccacc cccagauccu gcgcggccgg     1080

augguguccg ggcagaagga ccgcuacacg uacaacgaca ccgucaucuu cgccugcaug     1140

uucggcuuca cccucaaggg cagcaagcag auccggugca acgcccaggg gaccugggag     1200

cccuccgccc cggugugcga gaaggagugc caggcgcccc ccaacauccu gaacggccag     1260

aaggaggacc gccacauggu gcgguucgac cccgggacga gcaucaagua cuccugcaac     1320

ccgggcuacg uccugguggg cgaggagagc auccagugca ccuccgaggg gguguggacc     1380

ccccccgucc cccagugcaa gguggccgcc ugcgaggcca ccggccgcca gcuccugacg     1440

aagccgcagc accaguucgu gcggcccgac gucaacagca gcugcgggga gggcuacaag     1500

cuguccggga gcguguacca ggagugccag ggcaccaucc ccugguucau ggagauccgc     1560

cucugcaagg agaucaccug ccccccgccc cccgugaucu acaacggcgc ccacaccggg     1620

uccagccugg aggacuuccc cuacggcacg accgucaccu acaccugcaa cccggggccc     1680

gagcgcggcg uggaguucuc ccugaucggg gagagcacga uccggugcac cuccaacgac     1740

caggagcgcg gcaccuggag cggccccgcg ccccucugca agcugucccu gcucgccgug     1800

cagugcagcc acguccacau cgccaacggg uacaagaucu ccggcaagga ggccccguac     1860

uucuacaacg acaccgugac cuucaagugc uacagcgggu ucacgcugaa gggcuccagc     1920

cagauccggu gcaaggccga caacaccugg gaccccgaga uccccgugug cgagaaggag     1980

accugccagc acguccgcca gucccugcag gagcucccgg cggggagccg gguggagcug     2040

gugaacaccu ccugccagga cggcuaccag cugacgggcc acgccuacca gaugugccag     2100

gacgccgaga acgggaucug guucaagaag aucccccucu gcaaggucau ccacugccac     2160

ccccccccgg ugaucgugaa cggcaagcac accgggauga uggccgagaa cuuccuguac     2220

ggcaacgagg ucagcuacga gugcgaccag ggguucuacc ugcucggcga gaagaagcug     2280

cagugccgca gcgacuccaa gggccacggg agcugguccg gccccagccc ccagugccug     2340

cggucccccc cggugacccg cugccccaac cccgagguga agcacgggua caagcucaac     2400

aagacccaca gcgcguacuc ccacaacgac aucgucuacg uggacugcaa ccccggcuuc     2460

aucaugaacg gcagccgggu gauccgcugc cacacggaca acaccugggu cccgggggug     2520

cccaccugca ucaagaaggc cuucaucggc ugcccccccc cgcccaagac ccccaacggg     2580

aaccacacgg gcgggaacau cgcccgguuc ucccccggca ugagcauccu guacuccugc     2640

gaccagggcu accugcuggu gggggaggcc cuccugcugu gcacccacga gggcaccugg     2700

agccagccgg ccccccacug caaggagguc aacugcucca gccccgcgga cauggacggg     2760

auccagaagg gccucgagcc ccgcaagaug uaccaguacg gggccguggu gacccuggag     2820

ugcgaggacg gcuacaugcu ggagggcucc ccgcagagcc agugccaguc cgaccaccag     2880

uggaaccccc cccucgccgu cugccggagc cgcucccugg cccccgugcu gugcgggauc     2940

gccgcgggcc ucauccugcu gacguuccuc aucgugauca cccuguacgu caucagcaag     3000

caccgggccc gcaacuacua caccgacacc agccagaagg aggccuucca ccuggaggcc     3060

cgggaggugu acuccgugga cccguacaac cccgccagcu ga                        3102


<210>  8090
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8090
augggcgccg ccggccuccu cggcgucuuc cucgcccucg ucgcccccgg cguccucggc       60

aucuccugcg gcuccccccc ccccauccuc aacggccgca ucuccuacua cuccaccccc      120

aucgccgucg gcaccgucau ccgcuacucc ugcuccggca ccuuccgccu caucggcgag      180

aagucccucc ucugcaucac caaggacaag gucgacggca ccugggacaa gcccgccccc      240

aagugcgagu acuucaacaa guacuccucc ugccccgagc ccaucguccc cggcggcuac      300

aagauccgcg gcuccacccc cuaccgccac ggcgacuccg ucaccuucgc cugcaagacc      360

aacuucucca ugaacggcaa caaguccguc uggugccagg ccaacaacau guggggcccc      420

acccgccucc ccaccugcgu cuccgucuuc ccccucgagu gccccgcccu ccccaugauc      480

cacaacggcc accacaccuc cgagaacguc ggcuccaucg cccccggccu cuccgucacc      540

uacuccugcg aguccggcua ccuccucguc ggcgagaaga ucaucaacug ccucuccucc      600

ggcaaguggu ccgccguccc ccccaccugc gaggaggccc gcugcaaguc ccucggccgc      660

uuccccaacg gcaaggucaa ggagcccccc auccuccgcg ucggcgucac cgccaacuuc      720

uucugcgacg agggcuaccg ccuccagggc ccccccuccu cccgcugcgu caucgccggc      780

cagggcgucg ccuggaccaa gaugcccguc ugcgaggaga ucuucugccc cucccccccc      840

cccauccuca acggccgcca caucggcaac ucccucgcca acgucuccua cggcuccauc      900

gucaccuaca ccugcgaccc cgaccccgag gagggcguca acuucauccu caucggcgag      960

uccacccucc gcugcaccgu cgacucccag aagaccggca ccugguccgg ccccgccccc     1020

cgcugcgagc ucuccaccuc cgccguccag ugcccccacc cccagauccu ccgcggccgc     1080

auggucuccg gccagaagga ccgcuacacc uacaacgaca ccgucaucuu cgccugcaug     1140

uucggcuuca cccucaaggg cuccaagcag auccgcugca acgcccaggg caccugggag     1200

cccuccgccc ccgucugcga gaaggagugc caggcccccc ccaacauccu caacggccag     1260

aaggaggacc gccacauggu ccgcuucgac cccggcaccu ccaucaagua cuccugcaac     1320

cccggcuacg uccucgucgg cgaggagucc auccagugca ccuccgaggg cgucuggacc     1380

ccccccgucc cccagugcaa ggucgccgcc ugcgaggcca ccggccgcca gcuccucacc     1440

aagccccagc accaguucgu ccgccccgac gucaacuccu ccugcggcga gggcuacaag     1500

cucuccggcu ccgucuacca ggagugccag ggcaccaucc ccugguucau ggagauccgc     1560

cucugcaagg agaucaccug cccccccccc cccgucaucu acaacggcgc ccacaccggc     1620

uccucccucg aggacuuccc cuacggcacc accgucaccu acaccugcaa ccccggcccc     1680

gagcgcggcg ucgaguucuc ccucaucggc gaguccacca uccgcugcac cuccaacgac     1740

caggagcgcg gcaccugguc cggccccgcc ccccucugca agcucucccu ccucgccguc     1800

cagugcuccc acguccacau cgccaacggc uacaagaucu ccggcaagga ggcccccuac     1860

uucuacaacg acaccgucac cuucaagugc uacuccggcu ucacccucaa gggcuccucc     1920

cagauccgcu gcaaggccga caacaccugg gaccccgaga uccccgucug cgagaaggag     1980

accugccagc acguccgcca gucccuccag gagcuccccg ccggcucccg cgucgagcuc     2040

gucaacaccu ccugccagga cggcuaccag cucaccggcc acgccuacca gaugugccag     2100

gacgccgaga acggcaucug guucaagaag aucccccucu gcaaggucau ccacugccac     2160

cccccccccg ucaucgucaa cggcaagcac accggcauga uggccgagaa cuuccucuac     2220

ggcaacgagg ucuccuacga gugcgaccag ggcuucuacc uccucggcga gaagaagcuc     2280

cagugccgcu ccgacuccaa gggccacggc uccugguccg gccccucccc ccagugccuc     2340

cgcucccccc ccgucacccg cugccccaac cccgagguca agcacggcua caagcucaac     2400

aagacccacu ccgccuacuc ccacaacgac aucgucuacg ucgacugcaa ccccggcuuc     2460

aucaugaacg gcucccgcgu cauccgcugc cacaccgaca acaccugggu ccccggcguc     2520

cccaccugca ucaagaaggc cuucaucggc ugcccccccc cccccaagac ccccaacggc     2580

aaccacaccg gcggcaacau cgcccgcuuc ucccccggca uguccauccu cuacuccugc     2640

gaccagggcu accuccucgu cggcgaggcc cuccuccucu gcacccacga gggcaccugg     2700

ucccagcccg ccccccacug caaggagguc aacugcuccu cccccgccga cauggacggc     2760

auccagaagg gccucgagcc ccgcaagaug uaccaguacg gcgccgucgu cacccucgag     2820

ugcgaggacg gcuacaugcu cgagggcucc ccccaguccc agugccaguc cgaccaccag     2880

uggaaccccc cccucgccgu cugccgcucc cgcucccucg cccccguccu cugcggcauc     2940

gccgccggcc ucauccuccu caccuuccuc aucgucauca cccucuacgu caucuccaag     3000

caccgcgccc gcaacuacua caccgacacc ucccagaagg aggccuucca ccucgaggcc     3060

cgcgaggucu acuccgucga ccccuacaac cccgccuccu ga                        3102


<210>  8091
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8091
augggcgccg cugggcugcu cggaguguuc cuugcacugg ucgcccccgg uguuuugggc       60

aucagcugcg gguccccucc accgauuuua aacggaagaa uaucuuacua uucaaccccc      120

aucgcggugg gcacaguaau uagguacagu uguagcggua cuuuucggcu gaucggggag      180

aagucccuac ucugcauuac gaaagacaag guggauggaa ccugggacaa accugcucca      240

aagugugaau auuucaauaa auacucuucg ugccccgagc cuaucguccc aggcggcuau      300

aagauacgcg ggucaacacc cuaccgacac ggagauagcg ugacuuuugc cuguaagacc      360

aacuucagua ugaaugguaa caaauccguu uggugccagg caaauaacau guggggcccu      420

acacgucugc caaccugugu gucugucuuu ccgcuugaau gccccgcccu gccuaugauc      480

cauaaugggc accauacuag cgagaacgug ggauccauug cuccaggcuu gucaguaaca      540

uauaguugug aaagcgguua ccuccugguu ggggagaaga ucauuaauug ccugucuucc      600

ggaaaauggu cagcagugcc cccuaccugu gaggaagcca gaugcaagag ccucggcagg      660

uucccaaacg gcaaagucaa ggagcccccg aucuuacggg ugggggugac ggcuaacuuu      720

uucugcgacg aaggauaccg ccugcaaggu ccucccaguu cuagaugugu cauagccggc      780

caggggguug cguggacuaa gaugccagug ugcgaggaga ucuuuugucc uuccccacca      840

cccauucuua auggaaggca cauuggcaau agcuuggcaa acguaucgua ugguucuauc      900

gugaccuaca caugcgaucc ugacccagaa gaggggguca auuucauccu gauuggcgaa      960

uccacucuac gguguaccgu ggauucacag aaaacaggaa ccuggagugg cccggcuccc     1020

cgcugcgagc ucagcacguc cgcuguucag uguccucauc cacaaauacu gcgagggaga     1080

auggugucug gacagaagga cagguauacu uacaacgaua cagucaucuu ugccugcaug     1140

uucgguuuua cccuuaaagg cagcaagcag auucggugua acgcacaggg gacuugggaa     1200

cccucagcuc cugugugcga gaaagagugu caagccccac ccaauauccu gaacggacag     1260

aaggaagacc gucacauggu acgcuucgau ccgggcacaa guauaaaaua uuccugcaau     1320

ccugguuacg uuuugguggg ggaggaaagc auucagugca ccucugaggg cgucuggacg     1380

ccacccgugc cucaguguaa ggucgcggcc ugcgaagcaa ccggaagaca acuccugaca     1440

aagccccagc accaguucgu gaggccagac guuaacucaa guuguggcga gggguauaaa     1500

uuaagcggau ccguguacca agagugccag gguacuaucc cuugguuuau ggaaauccgg     1560

cuguguaagg agauuaccug cccacccccg ccuguaaucu acaauggcgc ucauacaggg     1620

ucuucgcucg aagauuuccc cuauggaacu accgucacau acaccuguaa cccaggcccc     1680

gagcgaggug uggaauuuag ccuuauuggg gaguccacua uacgcugcac gucaaaugac     1740

caggagagag gcacauggag uggaccugcc ccacugugua aauugucucu acuggcuguu     1800

cagugcagcc acgugcauau cgccaacggc uauaagauuu ccgggaaaga agcacccuac     1860

uucuauaaug acaccgucac uuuuaagugu uacucaggau ucacccucaa gggcagcucu     1920

caaaucaggu gcaaagccga uaacacaugg gacccugaga ucccggugug cgaaaaggag     1980

accugucagc acguacggca gucccugcag gagcuuccag cugguagucg cguggaacug     2040

guuaauacua gcugccaaga uggguaucag uugacaggac acgcguacca gaugugucag     2100

gacgcagaga acggcauuug guuuaaaaag auaccccucu gcaaagucau ccauugucac     2160

ccuccacccg ugauugugaa ugguaagcau acgggcauga uggccgaaaa cuuccuguac     2220

gggaaugagg ucucuuauga augcgaucaa ggauuuuacu uacugggcga gaagaaacua     2280

caguguagau ccgacucaaa ggggcacgga aguuggagcg gcccuucgcc gcagugccuc     2340

agguccccuc ccguuacccg uugucccaac cccgagguga aacaugguua uaagcugaac     2400

aaaacucacu cugcuuacag ccacaaugau aucguguaug uagacugcaa cccaggguuc     2460

auuaugaaug gaucacgggu cauccgaugu cauacagaua acaccugggu gccuggcguu     2520

cccacaugca uaaagaaggc cuuuaucggu ugcccaccgc cucccaaaac uccaaauggc     2580

aaccacaccg ggggaaauau ugcaagauuc agucccggca uguccauccu uuacucuugu     2640

gaccaggggu auuugcuggu gggagaagcc cuccugcuuu gcacgcauga gggcaccugg     2700

agccaaccug cuccacacug uaaggaaguc aacugcuccu cacccgccga uauggacggu     2760

auucagaaag ggcuggagcc uaggaagaug uaccaguacg gagcaguggu uacauuggaa     2820

ugugaggacg gcuauaugcu cgaggguagc ccgcaaaguc agugccaguc ugaucaccag     2880

uggaauccac cccuggcggu gugucgcucc cggagcuuag cuccuguacu gugcggcauc     2940

gccgcagggc uaauacuccu gacuuuucuu auugucauca ccuuguacgu gauuucgaaa     3000

cauagagcca ggaacuauua cacagacacu ucacaaaagg aagccuucca ccuggaggcc     3060

cgcgaagugu auucugucga ucccuacaau ccagcaaguu ga                        3102


<210>  8092
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8092
augggcgccg ccggccugcu gggcguguuc cuggcccugg uggcccccgg cgugcugggc       60

aucagcugcg gcagcccccc ccccauccug aacggcagaa ucagcuacua cagcaccccc      120

aucgccgugg gcaccgugau cagauacagc ugcagcggca ccuucagacu gaucggcgag      180

aagagccugc ugugcaucac caaggacaag guggacggca ccugggacaa gcccgccccc      240

aagugcgagu acuucaacaa guacagcagc ugccccgagc ccaucgugcc cggcggcuac      300

aagaucagag gcagcacccc cuacagacac ggcgacagcg ugaccuucgc cugcaagacc      360

aacuucagca ugaacggcaa caagagcgug uggugccagg ccaacaacau guggggcccc      420

accagacugc ccaccugcgu gagcguguuc ccccuggagu gccccgcccu gcccaugauc      480

cacaacggcc accacaccag cgagaacgug ggcagcaucg cccccggccu gagcgugacc      540

uacagcugcg agagcggcua ccugcuggug ggcgagaaga ucaucaacug ccugagcagc      600

ggcaagugga gcgccgugcc ccccaccugc gaggaggcca gaugcaagag ccugggcaga      660

uuccccaacg gcaaggugaa ggagcccccc auccugagag ugggcgugac cgccaacuuc      720

uucugcgacg agggcuacag acugcagggc ccccccagca gcagaugcgu gaucgccggc      780

cagggcgugg ccuggaccaa gaugcccgug ugcgaggaga ucuucugccc cagccccccc      840

cccauccuga acggcagaca caucggcaac agccuggcca acgugagcua cggcagcauc      900

gugaccuaca ccugcgaccc cgaccccgag gagggcguga acuucauccu gaucggcgag      960

agcacccuga gaugcaccgu ggacagccag aagaccggca ccuggagcgg ccccgccccc     1020

agaugcgagc ugagcaccag cgccgugcag ugcccccacc cccagauccu gagaggcaga     1080

auggugagcg gccagaagga cagauacacc uacaacgaca ccgugaucuu cgccugcaug     1140

uucggcuuca cccugaaggg cagcaagcag aucagaugca acgcccaggg caccugggag     1200

cccagcgccc ccgugugcga gaaggagugc caggcccccc ccaacauccu gaacggccag     1260

aaggaggaca gacacauggu gagauucgac cccggcacca gcaucaagua cagcugcaac     1320

cccggcuacg ugcugguggg cgaggagagc auccagugca ccagcgaggg cguguggacc     1380

ccccccgugc cccagugcaa gguggccgcc ugcgaggcca ccggcagaca gcugcugacc     1440

aagccccagc accaguucgu gagacccgac gugaacagca gcugcggcga gggcuacaag     1500

cugagcggca gcguguacca ggagugccag ggcaccaucc ccugguucau ggagaucaga     1560

cugugcaagg agaucaccug cccccccccc cccgugaucu acaacggcgc ccacaccggc     1620

agcagccugg aggacuuccc cuacggcacc accgugaccu acaccugcaa ccccggcccc     1680

gagagaggcg uggaguucag ccugaucggc gagagcacca ucagaugcac cagcaacgac     1740

caggagagag gcaccuggag cggccccgcc ccccugugca agcugagccu gcuggccgug     1800

cagugcagcc acgugcacau cgccaacggc uacaagauca gcggcaagga ggcccccuac     1860

uucuacaacg acaccgugac cuucaagugc uacagcggcu ucacccugaa gggcagcagc     1920

cagaucagau gcaaggccga caacaccugg gaccccgaga uccccgugug cgagaaggag     1980

accugccagc acgugagaca gagccugcag gagcugcccg ccggcagcag aguggagcug     2040

gugaacacca gcugccagga cggcuaccag cugaccggcc acgccuacca gaugugccag     2100

gacgccgaga acggcaucug guucaagaag aucccccugu gcaaggugau ccacugccac     2160

cccccccccg ugaucgugaa cggcaagcac accggcauga uggccgagaa cuuccuguac     2220

ggcaacgagg ugagcuacga gugcgaccag ggcuucuacc ugcugggcga gaagaagcug     2280

cagugcagaa gcgacagcaa gggccacggc agcuggagcg gccccagccc ccagugccug     2340

agaagccccc ccgugaccag augccccaac cccgagguga agcacggcua caagcugaac     2400

aagacccaca gcgccuacag ccacaacgac aucguguacg uggacugcaa ccccggcuuc     2460

aucaugaacg gcagcagagu gaucagaugc cacaccgaca acaccugggu gcccggcgug     2520

cccaccugca ucaagaaggc cuucaucggc ugcccccccc cccccaagac ccccaacggc     2580

aaccacaccg gcggcaacau cgccagauuc agccccggca ugagcauccu guacagcugc     2640

gaccagggcu accugcuggu gggcgaggcc cugcugcugu gcacccacga gggcaccugg     2700

agccagcccg ccccccacug caaggaggug aacugcagca gccccgccga cauggacggc     2760

auccagaagg gccuggagcc cagaaagaug uaccaguacg gcgccguggu gacccuggag     2820

ugcgaggacg gcuacaugcu ggagggcagc ccccagagcc agugccagag cgaccaccag     2880

uggaaccccc cccuggccgu gugcagaagc agaagccugg cccccgugcu gugcggcauc     2940

gccgccggcc ugauccugcu gaccuuccug aucgugauca cccuguacgu gaucagcaag     3000

cacagagcca gaaacuacua caccgacacc agccagaagg aggccuucca ccuggaggcc     3060

agagaggugu acagcgugga ccccuacaac cccgccagcu ga                        3102


<210>  8093
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_CR2__Homo_sapiens__CCDS1478.1

<400>  8093
augggcgccg cugggcugcu cggaguguuc cuggcccuug ucgcgcccgg cguucugggg       60

aucagcugcg gauccccucc gcccauucuc aacggcagaa ucucuuacua uagcaccccu      120

auugcugugg ggacagugau ccgguacucc uguucuggaa cguuucgccu gauuggcgaa      180

aagagccuuc ugugcaucac caaagacaag gucgauggca caugggacaa acccgccccu      240

aagugugagu auuucaauaa auacuccucu ugccccgagc cuaucgugcc cgggggauau      300

aagauuagag gcagcacccc cuaccggcac ggggauuccg uuacauuugc cuguaagacc      360

aacuucagca ugaauggaaa caaaucugug uggugccagg cuaauaacau guggggcccu      420

acacgccucc ccaccugugu cuccguguuu ccucuggaau gccccgcccu gccgaugauc      480

cauaaugggc accauacgag cgagaacguu ggaucuauug cuccuggccu cuccgugacc      540

uauagcugug aaucuggcua ccugcuuguc ggggagaaga ucauuaauug ccuguccagc      600

ggaaaauggu ccgccgugcc cccuacaugu gaggaagcga gaugcaaguc ucucggccgg      660

uuccccaacg ggaaagugaa ggagcccccu auccugcgcg ucggaguuac cgccaacuuu      720

uucugcgacg aaggcuacag acuucaaggg ccgcccagcu cccggugugu gauugcugga      780

cagggcgugg ccuggacaaa gaugccuguc ugcgaggaga ucuuuugucc cagcccuccc      840

ccgauccuga auggccgcca cauuggaaau ucucucgcua acguguccua ugggagcauc      900

guuaccuaca cgugcgaucc ugaccccgaa gagggcguga auuucauucu gaucggggaa      960

ucuacacuga gauguaccgu cgauagccag aaaacaggaa ccugguccgg cccugcgccc     1020

cggugcgagc ucucuaccag cgccgugcag uguccucauc cccaaauucu gcgcgggaga     1080

augguuuccg gccagaagga ccgguauaca uacaacgaua cggugaucuu ugccugcaug     1140

uucggauuua cccuuaaagg cagcaagcag auccgcugua acgcucaggg gacaugggaa     1200

ccgucugccc cugucugcga gaaagagugu caagcuccgc ccaauauucu gaacggacag     1260

aaggaagaca gacacauggu gcgguucgau ccuggcaccu ccaucaaaua uagcugcaau     1320

ccgggguacg uccucguggg agaggaaucu auucagugca cauccgaggg cguuuggacg     1380

cccccugugc cccaguguaa ggucgccgcc ugcgaagcua ccgggagaca acugcuuaca     1440

aagccucagc accaguucgu gcgccccgac guuaacagcu ccuguggcga gggauauaaa     1500

cugucuggca gcguguacca agagugccag gggaccaucc cuugguuuau ggaaauucgg     1560

cucuguaagg agauuaccug cccgcccccu cccgucaucu acaauggagc gcauacaggc     1620

uccucucugg aagauuuccc uuaugggacc acagugacgu acaccuguaa ccccggaccg     1680

gagagaggcg uggaauuuag ccugaucggg gaguccacaa uccgcugcac cagcaaugac     1740

caggagcggg gcacaugguc uggaccugcu ccccucugua aacugucccu ucuggccguu     1800

cagugcagcc acguccauau ugccaacggc uauaagaucu cugggaaaga agccccuuac     1860

uucuauaaug acaccgugac guuuaagugu uacuccggau ucacccucaa gggcagcucu     1920

caaauuagau gcaaagcuga uaacacaugg gaccccgaga uccccgugug cgaaaaggag     1980

accugucagc acguccgcca gagccugcag gagcuuccug ccgggucccg gguggaacug     2040

guuaauacaa gcugccaaga uggauaucag cucaccggcc acgcguacca gaugugucag     2100

gacgcugaga acgggauuug guuuaaaaag aucccgcugu gcaaagugau ccauugucau     2160

cccccucccg ucauugugaa uggcaagcac acgggaauga uggccgaaaa cuuccuguac     2220

ggcaaugagg uuucuuauga augcgaucaa ggguuuuacc uccugggaga gaagaaacuu     2280

caguguagau ccgacagcaa gggccacggg uccuggucug gaccuagccc ccagugccug     2340

cgcuccccuc cggugacacg gugucccaac ccugagguca aacauggcua uaagcucaac     2400

aaaacccacu cugccuacag ccacaaugau aucguguaug uugacugcaa ccccggcuuc     2460

auuaugaaug gguccagagu gauccgcugu cauacagaua acaccugggu cccuggagug     2520

ccgaccugca uuaagaaggc uuuuaucggc ugucccccuc cucccaaaac acccaauggg     2580

aaccacacgg gaggcaauau cgcccgguuc ucucccggga ugagcauucu guacuccugc     2640

gaccagggau aucugcuugu gggcgaagcu cuccugcugu gcacccauga gggcacaugg     2700

agccaaccug ccccgcacug uaaggaaguc aacuguucuu cccccgcgga uauggacggg     2760

auccagaaag gacucgagcc uagaaagaug uaccaguacg gcgccguugu gacccuggaa     2820

ugcgaggacg gguauaugcu ugagggaagc ccccaaucuc agugccaguc cgaucaccag     2880

uggaauccuc cccuggcugu gugucggagc cgcucucucg ccccgguccu gugcggcauu     2940

gcugccgggc ugauccuucu cacauuucug auugugauca cccuguacgu uaucuccaaa     3000

cauagagcgc ggaacuauua cacggacaca agccaaaagg aagccuucca ccucgaggcu     3060

agagaagugu auuccgucga uccuuacaau cccgccagcu ga                        3102


<210>  8094
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR3__Homo_sapiens__D3DSM0

<400>  8094

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Phe Gly 
            100                 105                 110         


Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr His Pro Asp 
        115                 120                 125             


Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys Gln Pro Pro 
    130                 135                 140                 


Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser Asn Gln Phe 
145                 150                 155                 160 


Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro 
                165                 170                 175     


Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu 
            180                 185                 190         


Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp 
        195                 200                 205             


Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro 
    210                 215                 220                 


Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys Arg Ser Asn 
225                 230                 235                 240 


Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu 
                245                 250                 255     


Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met Val Lys Thr 
            260                 265                 270         


Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val Gly Glu Leu 
        275                 280                 285             


Ser Glu Asp Ser Ser Asn Val Val His Leu Ile Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu Pro Asp Thr 
305                 310                 315                 320 


Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val Thr His Arg 
                325                 330                 335     


Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile 
            340                 345                 350         


Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln Glu Gln Ser 
        355                 360                 365             


Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr Val Gln Val 
    370                 375                 380                 


Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg Asp Arg Ser 
385                 390                 395                 400 


Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys Arg Cys Asp 
                405                 410                 415     


Thr Gly Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln Gly Arg Ser 
            420                 425                 430         


Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn Ser Ile Ile 
        435                 440                 445             


Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu Cys His Thr 
    450                 455                 460                 


Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys Glu Cys Asp 
465                 470                 475                 480 


Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly Gly Pro Gly 
                485                 490                 495     


Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro Gly Phe Glu 
            500                 505                 510         


Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys Leu Asn Pro 
        515                 520                 525             


Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys Asn Val Cys 
    530                 535                 540                 


Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu Cys Pro Gly 
545                 550                 555                 560 


Cys Pro Ser Pro Cys Gly Lys Tyr Ile Ser Cys Ala Glu Cys Leu Lys 
                565                 570                 575     


Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala Cys Pro Gly 
            580                 585                 590         


Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys Lys Glu Arg 
        595                 600                 605             


Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln Gln Asp Gly 
    610                 615                 620                 


Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu Cys Val Ala 
625                 630                 635                 640 


Gly Pro Asn Ile Ala Ala Ile Val Gly Gly Thr Val Ala Gly Ile Val 
                645                 650                 655     


Leu Ile Gly Ile Leu Leu Leu Val Ile Trp Lys Ala Leu Ile His Leu 
            660                 665                 670         


Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu Lys Glu Lys Leu Lys Ser 
        675                 680                 685             


Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys Ser Ala Thr Thr Thr Val 
    690                 695                 700                 


Met Asn Pro Lys Phe Ala Glu Ser 
705                 710         


<210>  8095
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8095
augcugggcc ugcgcccccc acugcucgcc cugguggggc ugcucucccu cgggugcguc       60

cucucucagg agugcacgaa guucaagguc agcagcugcc gggaaugcau cgagucgggg      120

cccggcugca ccuggugcca gaagcugaac uucacagggc cgggggaucc ugacuccauu      180

cgcugcgaca cccggccaca gcugcucaug aggggcugug cggcugacga caucauggac      240

cccacaagcc ucgcugaaac ccaggaagac cacaaugggg gccagaagca gcugucccca      300

caaaaaguga cgcuuuaccu gcgaccaggc uucggguccu ucguggacaa gaccgugcug      360

ccguucguga acacgcaccc ugauaagcug cgaaacccau gccccaacaa ggagaaagag      420

ugccagcccc cguuugccuu caggcacgug cugaagcuga ccaacaacuc caaccaguuu      480

cagaccgagg ucgggaagca gcugauuucc ggaaaccugg augcacccga gggugggcug      540

gacgccauga ugcaggucgc cgccugcccg gaggaaaucg gcuggcgcaa cgucacgcgg      600

cugcuggugu uugccacuga ugacggcuuc cauuucgcgg gcgacgggaa gcugggcgcc      660

auccugaccc ccaacgacgg ccgcugucac cuggaggaca acuuguacaa gaggagcaac      720

gaauucgacu acccaucggu gggccagcug gcgcacaagc uggcugaaaa caacauccag      780

cccaucuucg cggugaccag uaggauggug aagaccuacg agaaacucac cgagaucauc      840

cccaagucag ccguggggga gcugucugag gacuccagca auguggucca ucucauuaag      900

aaugcuuaca auaaacucuc cuccaggguc uuccuggauc acaacgcccu ccccgacacc      960

cugaaaguca ccuacgacuc cuucugcagc aauggaguga cgcacaggaa ccagcccaga     1020

ggugacugug auggcgugca gaucaauguc ccgaucaccu uccaggugaa ggucacggcc     1080

acagagugca uccaggagca gucguuuguc auccgggcgc ugggcuucac ggacauagug     1140

accgugcagg uccuucccca gugugagugc cggugccggg accagagcag agaccgcagc     1200

cucugccaug gcaagggcuu cuuggagugc ggcaucugca ggugugacac uggcuacauu     1260

gggaaaaacu gugagugcca gacacagggc cggagcagcc aggagcugga aggaagcugc     1320

cggaaggaca acaacuccau caucugcuca gggcuggggg acugugucug cgggcagugc     1380

cugugccaca ccagcgacgu ccccggcaag cugauauacg ggcaguacug cgagugugac     1440

accaucaacu gugagcgcua caacggccag gucugcggcg gcccggggag ggggcucugc     1500

uucugcggga agugccgcug ccacccgggc uuugagggcu cagcgugcca gugcgagagg     1560

accacugagg gcugccugaa cccgcggcgu guugagugua guggucgugg ccggugccgc     1620

ugcaacguau gcgagugcca uucaggcuac cagcugccuc ugugccagga gugccccggc     1680

ugccccucac ccuguggcaa guacaucucc ugcgccgagu gccugaaguu cgaaaagggc     1740

cccuuuggga agaacugcag cgcggcgugu ccgggccugc agcugucgaa caaccccgug     1800

aagggcagga ccugcaagga gagggacuca gagggcugcu ggguggccua cacgcuggag     1860

cagcaggacg ggauggaccg cuaccucauc uauguggaug agagccgaga guguguggca     1920

ggccccaaca ucgccgccau cgucgggggc accguggcag gcaucgugcu gaucggcauu     1980

cuccugcugg ucaucuggaa ggcucugauc caccugagcg accuccggga guacaggcgc     2040

uuugagaagg agaagcucaa gucccagugg aacaaugaua auccccuuuu caagagcgcc     2100

accacgacgg ucaugaaccc caaguuugcu gagaguuag                            2139


<210>  8096
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8096
augcugggcc uccggccccc gcugcuggcc cucguggggc ugcugagccu cggcugcguc       60

cugucccagg agugcaccaa guucaaggug agcuccugcc gcgagugcau cgagagcggg      120

cccggcugca ccuggugcca gaagcugaac uucacggggc ccggcgaccc cgacuccauc      180

cgcugcgaca cccggccgca gcuccugaug cgcggcugcg ccgcggacga caucauggac      240

cccaccagcc uggccgagac ccaggaggac cacaacgggg gccagaagca gcucagcccc      300

cagaagguga cgcuguaccu gcggcccggg uucggcuccu ucgucgacaa gaccgugcuc      360

ccguucguga acacccaccc cgacaagcug cgcaaccccu gccccaacaa ggagaaggag      420

ugccagccgc ccuucgccuu ccggcacguc cugaagcuca ccaacaacuc caaccaguuc      480

cagacggagg uggggaagca gcugaucagc ggcaaccugg acgcccccga gggcgggcuc      540

gacgccauga ugcaggucgc ggccugcccc gaggagaucg gcuggcgcaa cgugacccgg      600

cugcuggugu ucgccaccga cgacggguuc cacuucgccg gcgacggcaa gcucggggcg      660

auccugaccc cgaacgacgg ccgcugccac cuggaggaca accucuacaa gcgguccaac      720

gaguucgacu accccagcgu ggggcagcug gcccacaagc uggccgagaa caacauccag      780

cccaucuucg ccgucacguc ccgcauggug aagaccuacg agaagcucac cgagaucauc      840

cccaagagcg ccgugggcga gcuguccgag gacagcucca acgucgugca ccugaucaag      900

aacgcguaca acaagcucag cucccgggug uuccuggacc acaacgcccu gccggacacc      960

cucaagguca cguacgacag cuucugcagc aacgggguga cccaccgcaa ccagccccgg     1020

ggcgacugcg acggcgugca gaucaacguc cccaucaccu uccaggugaa ggugaccgcc     1080

acggagugca uccaggagca guccuucguc auccgcgccc ugggguucac cgacaucgug     1140

accguccagg ugcugcccca gugcgagugc cggugccgcg accagagccg ggaccgcucc     1200

cucugccacg gcaagggguu ccuggagugc ggcaucugcc ggugcgacac cggguacauc     1260

ggcaagaacu gcgagugcca gacgcagggc cgcagcuccc aggagcugga ggggagcugc     1320

cgcaaggaca acaacuccau caucugcagc ggccucgggg acugcgugug cggccagugc     1380

cugugccaca ccuccgacgu cccggggaag cugaucuacg gccaguacug cgagugcgac     1440

accaucaacu gcgagcggua caacggccag gugugcgggg gccccgggcg cggccucugc     1500

uucugcggca agugccggug ccaccccggg uucgagggca gcgccugcca gugcgagcgc     1560

accacggagg ggugccugaa cccccggcgc guggagugcu ccggccgggg gcgcugccgg     1620

ugcaacgucu gcgagugcca cagcggcuac cagcugccgc ucugccagga gugccccggc     1680

ugccccuccc cgugcgggaa guacaucagc ugcgcggagu gccugaaguu cgagaagggc     1740

cccuucggga agaacugcuc cgccgccugc cccggccugc agcugagcaa caaccccgug     1800

aaggggcgga ccugcaagga gcgcgacucc gagggcugcu ggguggccua cacccucgag     1860

cagcaggacg gcauggaccg cuaccugauc uacgucgacg agagccggga gugcguggcc     1920

gggccgaaca ucgcggccau cgugggcggg accgucgccg gcaucgugcu gaucgggauc     1980

cuccugcugg ugaucuggaa ggcccucauc caccuguccg accugcgcga guaccggcgc     2040

uucgagaagg agaagcucaa gagccagugg aacaacgaca acccccuguu caagagcgcc     2100

acgaccaccg ucaugaaccc caaguucgcg gaguccuga                            2139


<210>  8097
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8097
augcucggcc uccgcccccc ccuccucgcc cucgucggcc uccucucccu cggcugcguc       60

cucucccagg agugcaccaa guucaagguc uccuccugcc gcgagugcau cgaguccggc      120

cccggcugca ccuggugcca gaagcucaac uucaccggcc ccggcgaccc cgacuccauc      180

cgcugcgaca cccgccccca gcuccucaug cgcggcugcg ccgccgacga caucauggac      240

cccaccuccc ucgccgagac ccaggaggac cacaacggcg gccagaagca gcucuccccc      300

cagaagguca cccucuaccu ccgccccggc uucggcuccu ucgucgacaa gaccguccuc      360

cccuucguca acacccaccc cgacaagcuc cgcaaccccu gccccaacaa ggagaaggag      420

ugccagcccc ccuucgccuu ccgccacguc cucaagcuca ccaacaacuc caaccaguuc      480

cagaccgagg ucggcaagca gcucaucucc ggcaaccucg acgcccccga gggcggccuc      540

gacgccauga ugcaggucgc cgccugcccc gaggagaucg gcuggcgcaa cgucacccgc      600

cuccucgucu ucgccaccga cgacggcuuc cacuucgccg gcgacggcaa gcucggcgcc      660

auccucaccc ccaacgacgg ccgcugccac cucgaggaca accucuacaa gcgcuccaac      720

gaguucgacu accccuccgu cggccagcuc gcccacaagc ucgccgagaa caacauccag      780

cccaucuucg ccgucaccuc ccgcaugguc aagaccuacg agaagcucac cgagaucauc      840

cccaaguccg ccgucggcga gcucuccgag gacuccucca acgucgucca ccucaucaag      900

aacgccuaca acaagcucuc cucccgcguc uuccucgacc acaacgcccu ccccgacacc      960

cucaagguca ccuacgacuc cuucugcucc aacggcguca cccaccgcaa ccagccccgc     1020

ggcgacugcg acggcgucca gaucaacguc cccaucaccu uccaggucaa ggucaccgcc     1080

accgagugca uccaggagca guccuucguc auccgcgccc ucggcuucac cgacaucguc     1140

accguccagg uccuccccca gugcgagugc cgcugccgcg accagucccg cgaccgcucc     1200

cucugccacg gcaagggcuu ccucgagugc ggcaucugcc gcugcgacac cggcuacauc     1260

ggcaagaacu gcgagugcca gacccagggc cgcuccuccc aggagcucga gggcuccugc     1320

cgcaaggaca acaacuccau caucugcucc ggccucggcg acugcgucug cggccagugc     1380

cucugccaca ccuccgacgu ccccggcaag cucaucuacg gccaguacug cgagugcgac     1440

accaucaacu gcgagcgcua caacggccag gucugcggcg gccccggccg cggccucugc     1500

uucugcggca agugccgcug ccaccccggc uucgagggcu ccgccugcca gugcgagcgc     1560

accaccgagg gcugccucaa cccccgccgc gucgagugcu ccggccgcgg ccgcugccgc     1620

ugcaacgucu gcgagugcca cuccggcuac cagcuccccc ucugccagga gugccccggc     1680

ugccccuccc ccugcggcaa guacaucucc ugcgccgagu gccucaaguu cgagaagggc     1740

cccuucggca agaacugcuc cgccgccugc cccggccucc agcucuccaa caaccccguc     1800

aagggccgca ccugcaagga gcgcgacucc gagggcugcu gggucgccua cacccucgag     1860

cagcaggacg gcauggaccg cuaccucauc uacgucgacg agucccgcga gugcgucgcc     1920

ggccccaaca ucgccgccau cgucggcggc accgucgccg gcaucguccu caucggcauc     1980

cuccuccucg ucaucuggaa ggcccucauc caccucuccg accuccgcga guaccgccgc     2040

uucgagaagg agaagcucaa gucccagugg aacaacgaca acccccucuu caaguccgcc     2100

accaccaccg ucaugaaccc caaguucgcc gaguccuga                            2139


<210>  8098
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8098
augcugggcc ucagaccccc ucuucuggcc uugguggggu uacugagccu aggaugcguc       60

cucucccagg aguguaccaa guucaaaguu ucuucaugca gggaauguau cgagaguggu      120

ccaggcugca caugguguca aaagcugaac uuuacugggc cgggagaccc cgauagcauu      180

cggugcgaca cgcgcccuca gcuucugaug cgaggcugug cugcagauga cauaauggau      240

ccaaccuccu uggccgaaac acaggaggac cacaauggug ggcagaaaca acucucuccc      300

cagaagguga cucuguaccu gcguccugga uucggcucgu uuguagauaa aaccgugcuc      360

ccauucguca acacacaucc cgacaaguua agaaauccuu gcccaaacaa ggaaaaagag      420

ugucagccgc ccuuugcguu caggcacgug cugaaacuua ccaauaacuc aaaucaguuu      480

caaacugagg uuggcaagca guugaucagc gggaaccugg augcuccuga aggaggucua      540

gacgccauga ugcaaguggc agccugccca gaggaaauug gcuggcggaa ugucacacgc      600

cuccuggugu ucgcuaccga ugacggguuu cauuucgcag gagauggcaa acuuggugcc      660

auccugacgc ccaacgacgg gagaugucac uuggaggaca aucucuauaa gaggaguaac      720

gaguuugauu acccuuccgu aggacagcug gcucauaagu uagccgaaaa uaacauucag      780

ccaaucuucg cgguuacuuc ucggauggug aagaccuaug agaaacugac agaaauaauc      840

cccaagagcg cagucggcga gcucuccgaa gacucaagua auguggugca ccuuauuaaa      900

aacgccuaca acaagcugag cucucgcguc uuuuuggauc acaaugcucu accggacacu      960

cugaaaguua ccuaugauuc cuucugcuca aacggcguga cacaucgaaa ucagccuaga     1020

ggggacugcg auggaguaca gaucaacgug cccauuaccu uccaagucaa ggugacggcc     1080

acugagugua uccaggagca gagcuuuguu auaagggcac ucgguuucac agacauugug     1140

accguccagg ugcugccaca augcgaaugu cggugccgug aucagagucg cgacagaucu     1200

cuuugucacg gcaaaggguu ucuggagugc ggaaucugua ggugcgauac uggcuacauu     1260

gguaagaauu gugaaugcca gacacagggg cgguccagcc aagaguugga aggcucgugu     1320

cgaaaggaca acaauucuau caucugcucc ggacucggcg acugcguaug ugggcagugc     1380

cugugucaua ccucagaugu uccuggaaaa uuaauuuaug gucaguacug cgagugugac     1440

acgauaaacu gcgagcgcua caauggccag gugugugggg gacccggcag aggucugugc     1500

uucuguggga aguguaggug ccacccaggc uuugaaggaa gugcuugcca augcgagcgg     1560

accacagaag gcugucuaaa cccccgcaga gucgagugca gcgggagggg acguugucgg     1620

ugcaaugugu gugaaugcca cuccgguuau cagcucccuc ugugucagga gugcccaggc     1680

uguccgucuc ccugcgggaa auacaucagc ugugccgagu gccuuaaguu cgaaaaagga     1740

ccuuuuggca agaacugcuc agcggccugu ccagguuugc agcugaguaa uaaccccguc     1800

aaggggcgaa cuugcaaaga gagagauucc gaaggcuguu ggguggcaua uacccucgag     1860

caacaggacg gaauggauag guaccugauu uauguugacg agagccgcga augcguggcu     1920

ggcccuaaua ucgccgcuau aguaggggga acagucgccg gcauugugcu uaucgguauc     1980

cuguugcucg uuauuuggaa ggcacugauc cauuuaucug aucugcggga guacagaagg     2040

uucgaaaaag agaagcuaaa aucacagugg aacaacgaca auccacucuu uaagagugcc     2100

acuaccacag ugaugaaccc caaguucgcu gaaagcuga                            2139


<210>  8099
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8099
augcugggcc ugagaccccc ccugcuggcc cuggugggcc ugcugagccu gggcugcgug       60

cugagccagg agugcaccaa guucaaggug agcagcugca gagagugcau cgagagcggc      120

cccggcugca ccuggugcca gaagcugaac uucaccggcc ccggcgaccc cgacagcauc      180

agaugcgaca ccagacccca gcugcugaug agaggcugcg ccgccgacga caucauggac      240

cccaccagcc uggccgagac ccaggaggac cacaacggcg gccagaagca gcugagcccc      300

cagaagguga cccuguaccu gagacccggc uucggcagcu ucguggacaa gaccgugcug      360

cccuucguga acacccaccc cgacaagcug agaaaccccu gccccaacaa ggagaaggag      420

ugccagcccc ccuucgccuu cagacacgug cugaagcuga ccaacaacag caaccaguuc      480

cagaccgagg ugggcaagca gcugaucagc ggcaaccugg acgcccccga gggcggccug      540

gacgccauga ugcagguggc cgccugcccc gaggagaucg gcuggagaaa cgugaccaga      600

cugcuggugu ucgccaccga cgacggcuuc cacuucgccg gcgacggcaa gcugggcgcc      660

auccugaccc ccaacgacgg cagaugccac cuggaggaca accuguacaa gagaagcaac      720

gaguucgacu accccagcgu gggccagcug gcccacaagc uggccgagaa caacauccag      780

cccaucuucg ccgugaccag cagaauggug aagaccuacg agaagcugac cgagaucauc      840

cccaagagcg ccgugggcga gcugagcgag gacagcagca acguggugca ccugaucaag      900

aacgccuaca acaagcugag cagcagagug uuccuggacc acaacgcccu gcccgacacc      960

cugaagguga ccuacgacag cuucugcagc aacggcguga cccacagaaa ccagcccaga     1020

ggcgacugcg acggcgugca gaucaacgug cccaucaccu uccaggugaa ggugaccgcc     1080

accgagugca uccaggagca gagcuucgug aucagagccc ugggcuucac cgacaucgug     1140

accgugcagg ugcugcccca gugcgagugc agaugcagag accagagcag agacagaagc     1200

cugugccacg gcaagggcuu ccuggagugc ggcaucugca gaugcgacac cggcuacauc     1260

ggcaagaacu gcgagugcca gacccagggc agaagcagcc aggagcugga gggcagcugc     1320

agaaaggaca acaacagcau caucugcagc ggccugggcg acugcgugug cggccagugc     1380

cugugccaca ccagcgacgu gcccggcaag cugaucuacg gccaguacug cgagugcgac     1440

accaucaacu gcgagagaua caacggccag gugugcggcg gccccggcag aggccugugc     1500

uucugcggca agugcagaug ccaccccggc uucgagggca gcgccugcca gugcgagaga     1560

accaccgagg gcugccugaa ccccagaaga guggagugca gcggcagagg cagaugcaga     1620

ugcaacgugu gcgagugcca cagcggcuac cagcugcccc ugugccagga gugccccggc     1680

ugccccagcc ccugcggcaa guacaucagc ugcgccgagu gccugaaguu cgagaagggc     1740

cccuucggca agaacugcag cgccgccugc cccggccugc agcugagcaa caaccccgug     1800

aagggcagaa ccugcaagga gagagacagc gagggcugcu ggguggccua cacccuggag     1860

cagcaggacg gcauggacag auaccugauc uacguggacg agagcagaga gugcguggcc     1920

ggccccaaca ucgccgccau cgugggcggc accguggccg gcaucgugcu gaucggcauc     1980

cugcugcugg ugaucuggaa ggcccugauc caccugagcg accugagaga guacagaaga     2040

uucgagaagg agaagcugaa gagccagugg aacaacgaca acccccuguu caagagcgcc     2100

accaccaccg ugaugaaccc caaguucgcc gagagcuga                            2139


<210>  8100
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_CR3__Homo_sapiens__EAX09383

<400>  8100
augcugggcc ucagaccccc ucugcuugcc cugguggggc uccugagccu uggaugcguc       60

cugucccagg aguguaccaa guucaaaguu ucuagcugcc gggaauguau cgaguccggc      120

ccggggugca caugguguca aaagcucaac uuuacgggac ccggcgaccc ugauucuauu      180

cgcugcgaca ccagacccca gcugcugaug cgggggugug cugccgauga caucauggau      240

ccuacaagcc ucgcggaaac ccaggaggac cacaauggag gccagaaaca acugucuccc      300

cagaagguga cacuuuaccu gcgcccuggc uucggguccu uuguggauaa aaccguccuc      360

ccguucguga acacacaucc cgacaagcug agaaauccuu gccccaacaa ggaaaaagag      420

ugucagccuc ccuuugcuuu ccggcacguu cuuaagcuga ccaauaacag caaucaguuu      480

caaacggagg ugggaaaaca gcucauuucc ggcaaccugg augccccgga agggggacug      540

gacgccauga ugcaggucgc ugccugcccu gaggaaaucg gcuggcgcaa ugugaccaga      600

cuccugguuu ucgcuacaga ugacggguuu cauuucgccg gagauggcaa acuuggcgcg      660

auucugaccc ccaacgacgg gcggugucac cucgaggaca aucuguauaa gcgcagcaac      720

gaguuugauu acccuucugu gggacagcuu gcccauaagc uggcugaaaa uaacauccaa      780

cccaucuucg ccgucacauc cagaauggug aagaccuaug agaaacucac ggaaauuauc      840

cccaagagcg cugugggcga gcugucugaa gacuccagca augucguuca ccugauuaaa      900

aacgccuaca acaagcucuc uucccgggug uuucuggauc acaaugcgcu uccugacaca      960

cugaaaguga ccuaugauag cuucugcucc aacgggguca cacaucgcaa ucagccgaga     1020

ggagacugcg auggcgugca gaucaacguu cccauuaccu uccaagugaa ggucaccgcc     1080

acagagugua uccaggagca gucuuuugug auucgggcuc ucggguucac ggacaucguu     1140

accgugcagg uccugccuca augcgaaugu cgcugcagag aucagagccg ggacagaucc     1200

cuuugucacg gaaaaggcuu ucuggagugc ggcaucuguc gcugcgauac aggguacauu     1260

ggaaagaauu gugaaugcca gacccagggc cggagcucuc aagagcucga aggguccugu     1320

agaaaggaca acaauagcau cauuugcucu ggacugggcg acugcgugug ugggcagugc     1380

cugugucaua caagcgaugu ccccggcaaa cucaucuaug gacaguacug cgagugugac     1440

accauuaacu gcgagcgcua caauggccag gugugugggg gaccuggccg ggggcugugc     1500

uucuguggaa agugcagaug ucaccccggc uuugaagggu ccgccugcca augcgagcgc     1560

acgacagaag gcugucuuaa cccgcggaga guugagugcu cuggacgcgg ccgguguaga     1620

ugcaaugugu gugaaugcca cagcggguau cagcugccuc ucugucagga gugccccgga     1680

uguccuuccc ccugcggcaa auacaucagc ugugcugagu gccugaaguu cgaaaaaggg     1740

ccuuuuggaa agaacugcuc ugccgccugu cccggccugc agcuuuccaa uaacccgguc     1800

aaggggcgga ccugcaaaga gcgcgauagc gaaggcuguu ggguggcuua uacccucgag     1860

caacaggacg gaauggauag auaccugauc uauguugacg agucucggga augcguggcg     1920

ggcccuaaua uugccgcuau cgucggggga acaguggccg gcauugugcu gaucgggauu     1980

cuccugcuug uuaucuggaa ggcccugauc caucucuccg aucugcgcga guacagacgg     2040

uucgaaaaag agaagcugaa aagccagugg aacaacgaca auccccuuuu uaaguccgcu     2100

accacaacgg ucaugaaccc caaguucgcc gaaucuuga                            2139


<210>  8101
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR3__Homo_sapiens__P05107

<400>  8101

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  8102
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8102
augcugggcc ugcgcccccc acugcucgcc cugguggggc ugcucucccu cgggugcguc       60

cucucucagg agugcacgaa guucaagguc agcagcugcc gggaaugcau cgagucgggg      120

cccggcugca ccuggugcca gaagcugaac uucacagggc cgggggaucc ugacuccauu      180

cgcugcgaca cccggccaca gcugcucaug aggggcugug cggcugacga caucauggac      240

cccacaagcc ucgcugaaac ccaggaagac cacaaugggg gccagaagca gcugucccca      300

caaaaaguga cgcuuuaccu gcgaccaggc caggcagcag cguucaacgu gaccuuccgg      360

cgggccaagg gcuaccccau cgaccuguac uaucugaugg accucuccua cuccaugcuu      420

gaugaccuca ggaaugucaa gaagcuaggu ggcgaccugc uccgggcccu caacgagauc      480

accgaguccg gccgcauugg cuucgggucc uucguggaca agaccgugcu gccguucgug      540

aacacgcacc cugauaagcu gcgaaaccca ugccccaaca aggagaaaga gugccagccc      600

ccguuugccu ucaggcacgu gcugaagcug accaacaacu ccaaccaguu ucagaccgag      660

gucgggaagc agcugauuuc cggaaaccug gaugcacccg agggugggcu ggacgccaug      720

augcaggucg ccgccugccc ggaggaaauc ggcuggcgca acgucacgcg gcugcuggug      780

uuugccacug augacggcuu ccauuucgcg ggcgacggga agcugggcgc cauccugacc      840

cccaacgacg gccgcuguca ccuggaggac aacuuguaca agaggagcaa cgaauucgac      900

uacccaucgg ugggccagcu ggcgcacaag cuggcugaaa acaacaucca gcccaucuuc      960

gcggugacca guaggauggu gaagaccuac gagaaacuca ccgagaucau ccccaaguca     1020

gccguggggg agcugucuga ggacuccagc aauguggucc aacucauuaa gaaugcuuac     1080

aauaaacucu ccuccagggu cuuccuggau cacaacgccc uccccgacac ccugaaaguc     1140

accuacgacu ccuucugcag caauggagug acgcacagga accagcccag aggugacugu     1200

gauggcgugc agaucaaugu cccgaucacc uuccagguga aggucacggc cacagagugc     1260

auccaggagc agucguuugu cauccgggcg cugggcuuca cggacauagu gaccgugcag     1320

guucuucccc agugugagug ccggugccgg gaccagagca gagaccgcag ccucugccau     1380

ggcaagggcu ucuuggagug cggcaucugc aggugugaca cuggcuacau ugggaaaaac     1440

ugugagugcc agacacaggg ccggagcagc caggagcugg aaggaagcug ccggaaggac     1500

aacaacucca ucaucugcuc agggcugggg gacugugucu gcgggcagug ccugugccac     1560

accagcgacg uccccggcaa gcugauauac gggcaguacu gcgaguguga caccaucaac     1620

ugugagcgcu acaacggcca ggucugcggc ggcccgggga gggggcucug cuucugcggg     1680

aagugccgcu gccacccggg cuuugagggc ucagcgugcc agugcgagag gaccacugag     1740

ggcugccuga acccgcggcg uguugagugu aguggucgug gccggugccg cugcaacgua     1800

ugcgagugcc auucaggcua ccagcugccu cugugccagg agugccccgg cugccccuca     1860

cccuguggca aguacaucuc cugcgccgag ugccugaagu ucgaaaaggg ccccuuuggg     1920

aagaacugca gcgcggcgug uccgggccug cagcugucga acaaccccgu gaagggcagg     1980

accugcaagg agagggacuc agagggcugc uggguggccu acacgcugga gcagcaggac     2040

gggauggacc gcuaccucau cuauguggau gagagccgag aguguguggc aggccccaac     2100

aucgccgcca ucgucggggg caccguggca ggcaucgugc ugaucggcau ucuccugcug     2160

gucaucugga aggcucugau ccaccugagc gaccuccggg aguacaggcg cuuugagaag     2220

gagaagcuca agucccagug gaacaaugau aauccccuuu ucaagagcgc caccacgacg     2280

gucaugaacc ccaaguuugc ugagaguuag                                      2310


<210>  8103
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8103
augcugggcc uccggccccc gcugcuggcc cucguggggc ugcugagccu cggcugcguc       60

cugucccagg agugcaccaa guucaaggug agcuccugcc gcgagugcau cgagagcggg      120

cccggcugca ccuggugcca gaagcugaac uucacggggc ccggcgaccc cgacuccauc      180

cgcugcgaca cccggccgca gcuccugaug cgcggcugcg ccgcggacga caucauggac      240

cccaccagcc uggccgagac ccaggaggac cacaacgggg gccagaagca gcucagcccc      300

cagaagguga cgcuguaccu gcggcccggg caggccgccg ccuucaacgu caccuuccgc      360

cgggcgaagg gcuacccgau cgaccucuac uaccugaugg accuguccua cuccaugcuc      420

gacgaccugc gcaacgugaa gaagcucggg ggcgaccugc ugcgggcccu gaacgagauc      480

accgagagcg gccgcaucgg guucggcucc uucguggaca agaccguccu ccccuucgug      540

aacacgcacc ccgacaagcu gcggaacccc ugcccgaaca aggagaagga gugccagccg      600

cccuucgccu uccgccacgu gcugaagcuc accaacaaca gcaaccaguu ccagaccgag      660

gucgggaagc agcugaucuc cggcaaccug gacgcccccg agggcgggcu cgacgcgaug      720

augcaggucg ccgccugccc cgaggagauc ggcuggcgga acgugacccg ccugcuggug      780

uucgccacgg acgacggguu ccacuucgcc ggcgacggga agcucggcgc gauccugacc      840

cccaacgacg gccggugcca ccuggaggac aaccucuaca agcgcagcaa cgaguucgac      900

uaccccuccg uggggcagcu ggcccacaag cuggccgaga acaacaucca gcccaucuuc      960

gccgugacca gccggauggu caagaccuac gagaagcuca cggagaucau cccgaagucc     1020

gccgugggcg agcugagcga ggacuccagc aacguggucc agcugaucaa gaacgcguac     1080

aacaagcuca gcucccgcgu guuccuggac cacaacgccc ugcccgacac ccucaaggug     1140

accuacgaca gcuucugcuc caacgggguc acccaccgga accagccccg cggcgacugc     1200

gacggggugc agaucaacgu gcccaucacg uuccagguca aggugaccgc caccgagugc     1260

auccaggagc agagcuucgu cauccgggcc cugggcuuca ccgacaucgu gacggugcag     1320

guccugccgc agugcgagug ccgcugccgc gaccaguccc gggaccgcag ccucugccac     1380

ggcaaggggu uccuggagug cggcaucugc cggugcgaca ccggguacau cggcaagaac     1440

ugcgagugcc agacccaggg gcgcuccagc caggagcugg agggcuccug ccggaaggac     1500

aacaacagca ucaucugcuc cggccugggg gacugcgugu gcggccagug ccucugccac     1560

accagcgacg ugcccgggaa gcugaucuac ggccaguacu gcgagugcga cacgaucaac     1620

ugcgagcgcu acaacggcca ggucugcggg ggccccgggc ggggccugug cuucugcggg     1680

aagugccgcu gccaccccgg cuucgagggc uccgccugcc agugcgagcg gaccaccgag     1740

gggugccuca acccgcgccg gguggagugc agcggccgcg ggcggugccg cugcaacgug     1800

ugcgagugcc acuccggcua ccagcugccc cugugccagg agugccccgg gugcccgagc     1860

cccugcggca aguacaucuc cugcgcggag ugccucaagu ucgagaaggg ccccuucggg     1920

aagaacugca gcgccgccug ccccggccug cagcugucca acaacccggu caaggggcgg     1980

accugcaagg agcgcgacag cgagggcugc uggguggccu acacgcucga gcagcaggac     2040

gggauggacc gguaccugau cuacguggac gagagccgcg agugcgucgc cggccccaac     2100

aucgcggcca ucgugggcgg gaccguggcc ggcaucgucc ugaucgggau ccuccugcug     2160

gugaucugga aggcccucau ccaccugucc gaccugcggg aguaccgccg cuucgagaag     2220

gagaagcuca agagccagug gaacaacgac aacccccugu ucaaguccgc gaccaccacg     2280

gugaugaacc ccaaguucgc cgagagcuga                                      2310


<210>  8104
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8104
augcucggcc uccgcccccc ccuccucgcc cucgucggcc uccucucccu cggcugcguc       60

cucucccagg agugcaccaa guucaagguc uccuccugcc gcgagugcau cgaguccggc      120

cccggcugca ccuggugcca gaagcucaac uucaccggcc ccggcgaccc cgacuccauc      180

cgcugcgaca cccgccccca gcuccucaug cgcggcugcg ccgccgacga caucauggac      240

cccaccuccc ucgccgagac ccaggaggac cacaacggcg gccagaagca gcucuccccc      300

cagaagguca cccucuaccu ccgccccggc caggccgccg ccuucaacgu caccuuccgc      360

cgcgccaagg gcuaccccau cgaccucuac uaccucaugg accucuccua cuccaugcuc      420

gacgaccucc gcaacgucaa gaagcucggc ggcgaccucc uccgcgcccu caacgagauc      480

accgaguccg gccgcaucgg cuucggcucc uucgucgaca agaccguccu ccccuucguc      540

aacacccacc ccgacaagcu ccgcaacccc ugccccaaca aggagaagga gugccagccc      600

cccuucgccu uccgccacgu ccucaagcuc accaacaacu ccaaccaguu ccagaccgag      660

gucggcaagc agcucaucuc cggcaaccuc gacgcccccg agggcggccu cgacgccaug      720

augcaggucg ccgccugccc cgaggagauc ggcuggcgca acgucacccg ccuccucguc      780

uucgccaccg acgacggcuu ccacuucgcc ggcgacggca agcucggcgc cauccucacc      840

cccaacgacg gccgcugcca ccucgaggac aaccucuaca agcgcuccaa cgaguucgac      900

uaccccuccg ucggccagcu cgcccacaag cucgccgaga acaacaucca gcccaucuuc      960

gccgucaccu cccgcauggu caagaccuac gagaagcuca ccgagaucau ccccaagucc     1020

gccgucggcg agcucuccga ggacuccucc aacgucgucc agcucaucaa gaacgccuac     1080

aacaagcucu ccucccgcgu cuuccucgac cacaacgccc uccccgacac ccucaagguc     1140

accuacgacu ccuucugcuc caacggcguc acccaccgca accagccccg cggcgacugc     1200

gacggcgucc agaucaacgu ccccaucacc uuccagguca aggucaccgc caccgagugc     1260

auccaggagc aguccuucgu cauccgcgcc cucggcuuca ccgacaucgu caccguccag     1320

guccuccccc agugcgagug ccgcugccgc gaccaguccc gcgaccgcuc ccucugccac     1380

ggcaagggcu uccucgagug cggcaucugc cgcugcgaca ccggcuacau cggcaagaac     1440

ugcgagugcc agacccaggg ccgcuccucc caggagcucg agggcuccug ccgcaaggac     1500

aacaacucca ucaucugcuc cggccucggc gacugcgucu gcggccagug ccucugccac     1560

accuccgacg uccccggcaa gcucaucuac ggccaguacu gcgagugcga caccaucaac     1620

ugcgagcgcu acaacggcca ggucugcggc ggccccggcc gcggccucug cuucugcggc     1680

aagugccgcu gccaccccgg cuucgagggc uccgccugcc agugcgagcg caccaccgag     1740

ggcugccuca acccccgccg cgucgagugc uccggccgcg gccgcugccg cugcaacguc     1800

ugcgagugcc acuccggcua ccagcucccc cucugccagg agugccccgg cugccccucc     1860

cccugcggca aguacaucuc cugcgccgag ugccucaagu ucgagaaggg ccccuucggc     1920

aagaacugcu ccgccgccug ccccggccuc cagcucucca acaaccccgu caagggccgc     1980

accugcaagg agcgcgacuc cgagggcugc ugggucgccu acacccucga gcagcaggac     2040

ggcauggacc gcuaccucau cuacgucgac gagucccgcg agugcgucgc cggccccaac     2100

aucgccgcca ucgucggcgg caccgucgcc ggcaucgucc ucaucggcau ccuccuccuc     2160

gucaucugga aggcccucau ccaccucucc gaccuccgcg aguaccgccg cuucgagaag     2220

gagaagcuca agucccagug gaacaacgac aacccccucu ucaaguccgc caccaccacc     2280

gucaugaacc ccaaguucgc cgaguccuga                                      2310


<210>  8105
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8105
augcugggcc ucagaccccc ucuucuggcc uugguggggu uacugagccu aggaugcguc       60

cucucccagg aguguaccaa guucaaaguu ucuucaugca gggaauguau cgagaguggu      120

ccaggcugca caugguguca aaagcugaac uuuacugggc cgggagaccc cgauagcauu      180

cggugcgaca cgcgcccuca gcuucugaug cgaggcugug cugcagauga cauaauggau      240

ccaaccuccu uggccgaaac acaggaggac cacaauggug ggcagaaaca acucucuccc      300

cagaagguga cucuguaccu gcguccugga caggcggcug ccuucaacgu aaccuuuaga      360

agggcaaaag gcuauccaau cgaucucuac uauuuaaugg accugucgua cucaaugcuu      420

gaugacuugc ggaaugugaa gaagcugggc ggggaucuac uccgcgcccu gaacgaaauu      480

acagagagcg gaagaaucgg uuucggcagu uuugucgaca aaaccgugcu ucccuucguu      540

aauacucauc cugauaagcu gaggaaccca ugcccgaaua aagagaagga augucagccc      600

ccuuuugcuu uccggcacgu guugaaacuc acaaacaauu ccaaccaauu ucagaccgag      660

gucgggaagc agcugauuuc uggaaauuua gacgcaccag aaggcggucu ggacgccaug      720

augcaagugg cugccugccc cgaggagauc ggguggcgca acguaacgcg acuccuuguu      780

uucgcgacug augacggauu ucauuucgca ggcgauggca agcugggggc cauauugacc      840

ccuaaugacg gaagauguca ccuagaagau aaccuguaua aaaggagcaa ugaguuugac      900

uacccauccg ugggucagcu cgcucauaag cuggccgaaa acaacaucca gcccauuuuc      960

gcagucacau cacggauggu gaaaacuuau gagaaacuua ccgaaaucau uccgaagagu     1020

gcugugggcg agcugagcga ggauucuucc aaugucguuc aguugaucaa gaacgccuac     1080

aauaaacucu caagccgugu guuccuggac cacaacgcgu uaccugauac acugaaggua     1140

accuacgaca guuuuugcuc uaauggggug acgcaccgca accaacccag aggagauugc     1200

gacggcgucc agauaaaugu gccaauuacu uuccagguua aggugacagc caccgaaugu     1260

auccaggagc aauccuuugu cauuagggca cuagguuuca cugacaucgu gacaguacag     1320

guucucccuc agugcgaaug ucggugccga gaucagagcc gcgacagauc gcugugucau     1380

gggaaaggcu uucuugagug cggaaucugu aggugcgaua ccggcuauau ugggaagaac     1440

ugugaaugcc aaacgcaggg acggucuucc caggaguugg aggguucaug ucgcaaagac     1500

aauaacagua uaaucugcag cggccugggg gauugcgugu guggacagug ccucugucac     1560

accuccgacg uccccggcaa gcugauuuac ggucaauauu gcgaauguga uacaaucaau     1620

ugcgagagau acaacggcca gguguguggg ggaccaggca gggggcuuug cuucugugga     1680

aaaugccguu gucaucccgg uuuugaaggc ucugcuugcc agugcgagcg gacuaccgaa     1740

gggugucuga auccucgaag agucgagugc agcggaaggg gccgcugucg gugcaacgug     1800

ugugagugcc acucagguua ucaguugcca cucugucaag aaugcccggg gugucccagu     1860

ccuugcggca aguacauauc cugugccgag ugccugaagu ucgaaaaagg accauuuggc     1920

aagaauugca gcgcugccug ucccggguua cagcugucua acaacccugu uaaaggaaga     1980

acaugcaagg agagggacuc agagggcugu uggguggcau auacucuaga acagcaagau     2040

gguauggacc gcuaccucau uuacguagau gagagucgag aaugcgucgc cgggccaaau     2100

aucgcugcga ucgugggagg caccguugca gguauugugc ugaucggcau ucuuuugcug     2160

gucauaugga aagcccucau ccaccugagc gacuuacggg aguaucguag auucgaaaag     2220

gagaagcuga aaucccagug gaacaaugau aacccccuuu uuaagucugc uacaaccacu     2280

gugaugaauc cgaaauucgc cgagucguga                                      2310


<210>  8106
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8106
augcugggcc ugagaccccc ccugcuggcc cuggugggcc ugcugagccu gggcugcgug       60

cugagccagg agugcaccaa guucaaggug agcagcugca gagagugcau cgagagcggc      120

cccggcugca ccuggugcca gaagcugaac uucaccggcc ccggcgaccc cgacagcauc      180

agaugcgaca ccagacccca gcugcugaug agaggcugcg ccgccgacga caucauggac      240

cccaccagcc uggccgagac ccaggaggac cacaacggcg gccagaagca gcugagcccc      300

cagaagguga cccuguaccu gagacccggc caggccgccg ccuucaacgu gaccuucaga      360

agagccaagg gcuaccccau cgaccuguac uaccugaugg accugagcua cagcaugcug      420

gacgaccuga gaaacgugaa gaagcugggc ggcgaccugc ugagagcccu gaacgagauc      480

accgagagcg gcagaaucgg cuucggcagc uucguggaca agaccgugcu gcccuucgug      540

aacacccacc ccgacaagcu gagaaacccc ugccccaaca aggagaagga gugccagccc      600

cccuucgccu ucagacacgu gcugaagcug accaacaaca gcaaccaguu ccagaccgag      660

gugggcaagc agcugaucag cggcaaccug gacgcccccg agggcggccu ggacgccaug      720

augcaggugg ccgccugccc cgaggagauc ggcuggagaa acgugaccag acugcuggug      780

uucgccaccg acgacggcuu ccacuucgcc ggcgacggca agcugggcgc cauccugacc      840

cccaacgacg gcagaugcca ccuggaggac aaccuguaca agagaagcaa cgaguucgac      900

uaccccagcg ugggccagcu ggcccacaag cuggccgaga acaacaucca gcccaucuuc      960

gccgugacca gcagaauggu gaagaccuac gagaagcuga ccgagaucau ccccaagagc     1020

gccgugggcg agcugagcga ggacagcagc aacguggugc agcugaucaa gaacgccuac     1080

aacaagcuga gcagcagagu guuccuggac cacaacgccc ugcccgacac ccugaaggug     1140

accuacgaca gcuucugcag caacggcgug acccacagaa accagcccag aggcgacugc     1200

gacggcgugc agaucaacgu gcccaucacc uuccagguga aggugaccgc caccgagugc     1260

auccaggagc agagcuucgu gaucagagcc cugggcuuca ccgacaucgu gaccgugcag     1320

gugcugcccc agugcgagug cagaugcaga gaccagagca gagacagaag ccugugccac     1380

ggcaagggcu uccuggagug cggcaucugc agaugcgaca ccggcuacau cggcaagaac     1440

ugcgagugcc agacccaggg cagaagcagc caggagcugg agggcagcug cagaaaggac     1500

aacaacagca ucaucugcag cggccugggc gacugcgugu gcggccagug ccugugccac     1560

accagcgacg ugcccggcaa gcugaucuac ggccaguacu gcgagugcga caccaucaac     1620

ugcgagagau acaacggcca ggugugcggc ggccccggca gaggccugug cuucugcggc     1680

aagugcagau gccaccccgg cuucgagggc agcgccugcc agugcgagag aaccaccgag     1740

ggcugccuga accccagaag aguggagugc agcggcagag gcagaugcag augcaacgug     1800

ugcgagugcc acagcggcua ccagcugccc cugugccagg agugccccgg cugccccagc     1860

cccugcggca aguacaucag cugcgccgag ugccugaagu ucgagaaggg ccccuucggc     1920

aagaacugca gcgccgccug ccccggccug cagcugagca acaaccccgu gaagggcaga     1980

accugcaagg agagagacag cgagggcugc uggguggccu acacccugga gcagcaggac     2040

ggcauggaca gauaccugau cuacguggac gagagcagag agugcguggc cggccccaac     2100

aucgccgcca ucgugggcgg caccguggcc ggcaucgugc ugaucggcau ccugcugcug     2160

gugaucugga aggcccugau ccaccugagc gaccugagag aguacagaag auucgagaag     2220

gagaagcuga agagccagug gaacaacgac aacccccugu ucaagagcgc caccaccacc     2280

gugaugaacc ccaaguucgc cgagagcuga                                      2310


<210>  8107
<211>  2310
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_CR3__Homo_sapiens__CAB90553

<400>  8107
augcugggac ucagaccccc ucugcuugcc cugguggggc uccugagccu uggaugcguc       60

cugucccagg aguguaccaa guucaaaguu ucuagcugcc gggaauguau cgaguccggc      120

ccggggugca caugguguca aaagcucaac uuuacgggac ccggcgaccc ugauucuauu      180

cgcugcgaca ccagacccca gcugcugaug cgggggugug cugccgauga caucauggau      240

ccuacaagcc ucgcggaaac ccaggaggac cacaauggag gccagaaaca acugagcccc      300

cagaagguga cacuuuaccu gcgcccuggc caggcugccg ccuucaacgu gaccuuuaga      360

cgggcuaaag gguauccgau ugaucucuac uaucugaugg accuuucuua cagcaugcug      420

gaugaccucc gcaaugucaa gaagcuggga ggcgaucugc ucagagcccu gaacgaaauc      480

acagaguccg ggcggauugg auucggcagc uuuguggaca aaaccguucu ucccuucgug      540

aauacgcauc cugauaagcu gcgcaacccc ugcccuaaua aagagaagga augucagccc      600

ccguuugcuu ucagacacgu ccucaaacug accaacaauu cuaaccaauu ucagacagag      660

guggggaagc agcuuaucuc cggaaaucug gacgccccug aaggcggccu cgacgcgaug      720

augcagguug ccgcuugccc cgaggagauc ggguggcgga acgugacccg ccugcugguc      780

uucgccacag augacggauu ucauuucgcu ggcgauggga agcucggagc cauucugacc      840

ccuaaugacg gcagauguca ccuugaagau aaccuguaua aacggagcaa ugaguuugac      900

uaccccucug uggggcaacu cgcgcauaag cuggccgaaa acaacaucca gcccauuuuc      960

gcugugacgu cccgcauggu caaaacauau gagaaacuua ccgaaaucau uccuaagagc     1020

gccguuggag agcugucuga ggauuccagc aauguggugc agcucaucaa gaacgcuuac     1080

aauaaacugu ccucuagagu cuuccuggac cacaacgccc ucccggauac acugaaggug     1140

accuacgaca gcuuuugcuc caauggcguu acccaccgga accaacccag aggcgauugc     1200

gacggggugc agauuaaugu cccuaucaca uuccagguga agguuacggc caccgaaugu     1260

auccaggagc aauccuuugu gauucgcgcu cuuggauuca cagacaucgu caccgugcag     1320

guccugcccc agugcgaaug ucggugcaga gaucagucuc gcgaccgguc ccucugucau     1380

ggcaaagggu uucuggagug cggaauuugu agaugcgaua caggcuauau cgggaagaac     1440

ugugaaugcc aaacccaggg ccgcagcucu caggagcugg agggaagcug ucggaaagac     1500

aauaacucca uuaucugcuc uggccuuggg gauugcgugu guggacagug ccucugucac     1560

acgagcgacg uuccuggcaa gcugaucuac gggcaauauu gcgaauguga uacaauuaau     1620

ugcgagagau acaacggaca gguguguggc gggcccggcc gcggacugug cuucuguggc     1680

aaaugccggu gucauccggg guuugaagga uccgcgugcc agugcgagag aaccaccgaa     1740

ggcugucuca auccucgccg ggucgagugc agcgggagag gacggugucg cugcaacgug     1800

ugugagugcc acucuggcua ucagcugccc cuuugucaag aaugcccugg gugucccucc     1860

ccuugcggca aguacaucag cugugccgag ugccugaagu ucgaaaaagg acccuuuggc     1920

aagaauugcu cugcugccug uccggggcuc cagcugucca acaacccugu uaaaggaaga     1980

acaugcaagg agcgggacag cgagggcugu uggguggccu auacccugga acagcaagau     2040

gggauggaca gauaccuuau uuacgucgau gagucccgcg aaugcguggc uggacccaau     2100

aucgccgcga uugugggcgg gacaguugcu ggcaucgucc ucaucggcau ucugcugcuc     2160

gugaucugga aagcccugau ucaccuuucu gaccugcggg aguauagacg cuucgaaaag     2220

gagaagcuca aaagccagug gaacaaugau aacccccugu uuaaguccgc cacgaccaca     2280

gugaugaauc cuaaauucgc ugagucuuga                                      2310


<210>  8108
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MASP-1__Homo_sapiens__P48740

<400>  8108

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 
        435                 440                 445             


Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 
    450                 455                 460                 


Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 
                485                 490                 495     


Asp Pro Glu Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 
            500                 505                 510         


Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 
        515                 520                 525             


Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Gln Tyr 
    530                 535                 540                 


Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 
545                 550                 555                 560 


Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 
                565                 570                 575     


Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 
            580                 585                 590         


Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 
        595                 600                 605             


Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 
    610                 615                 620                 


Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 
625                 630                 635                 640 


Ala Cys Ala Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 
                645                 650                 655     


Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 
            660                 665                 670         


Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 
        675                 680                 685             


Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 
    690                 695                 


<210>  8109
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8109
augagguggc ugcuucucua uuaugcucug ugcuucuccc ugucaaaggc uucagcccac       60

accguggagc uaaacaauau guuuggccag auccagucgc cugguuaucc agacuccuau      120

cccagugauu cagaggugac uuggaauauc acugucccag auggguuucg gaucaagcuu      180

uacuucaugc acuucaacuu ggaauccucc uaccuuugug aauaugacua ugugaaggua      240

gaaacugagg accaggugcu ggcaaccuuc uguggcaggg agaccacaga cacagagcag      300

acucccggcc aggagguggu ccucuccccu ggcuccuuca uguccaucac uuuccgguca      360

gauuucucca augaggagcg uuucacaggc uuugaugccc acuacauggc uguggaugug      420

gacgagugca aggagaggga ggacgaggag cuguccugug accacuacug ccacaacuac      480

auuggcggcu acuacugcuc cugccgcuuc ggcuacaucc uccacacaga caacaggacc      540

ugccgagugg agugcaguga caaccucuuc acucaaagga cuggggugau caccagcccu      600

gacuucccaa acccuuaccc caagagcucu gaaugccugu auaccaucga gcuggaggag      660

gguuucaugg ucaaccugca guuugaggac auauuugaca uugaggacca uccugaggug      720

cccugccccu augacuacau caagaucaaa guugguccaa aaguuuuggg gccuuucugu      780

ggagagaaag ccccagaacc caucagcacc cagagccaca guguccugau ccuguuccau      840

agugacaacu cgggagagaa ccggggcugg aggcucucau acagggcugc aggaaaugag      900

ugcccagagc uacagccucc uguccauggg aaaaucgagc ccucccaagc caaguauuuc      960

uucaaagacc aagugcucgu cagcugugac acaggcuaca aagugcugaa ggauaaugug     1020

gagauggaca cauuccagau ugagugucug aaggauggga cguggaguaa caagauuccc     1080

accuguaaaa uuguagacug uagagcccca ggagagcugg aacacgggcu gaucaccuuc     1140

ucuacaagga acaaccucac cacauacaag ucugagauca aauacuccug ucaggagccc     1200

uauuacaaga ugcucaacaa uaacacaggu auauauaccu guucugccca aggagucugg     1260

augaauaaag uauuggggag aagccuaccc accugccuuc cagugugugg gcuccccaag     1320

uucucccgga agcugauggc caggaucuuc aauggacgcc cagcccagaa aggcaccacu     1380

cccuggauug ccaugcuguc acaccugaau gggcagcccu ucugcggagg cucccuucua     1440

ggcuccagcu ggaucgugac cgccgcacac ugccuccacc agucacucga uccggaagau     1500

ccgacccuac gugauucaga cuugcucagc ccuucugacu ucaaaaucau ccugggcaag     1560

cauuggaggc uccggucaga ugaaaaugaa cagcaucucg gcgucaaaca caccacucuc     1620

cacccccagu augaucccaa cacauucgag aaugacgugg cucuggugga gcuguuggag     1680

agcccagugc ugaaugccuu cgugaugccc aucugucugc cugagggacc ccagcaggaa     1740

ggagccaugg ucaucgucag cggcuggggg aagcaguucu ugcaaagguu cccagagacc     1800

cugauggaga uugaaauccc gauuguugac cacagcaccu gccagaaggc uuaugccccg     1860

cugaagaaga aagugaccag ggacaugauc ugugcugggg agaaggaagg gggaaaggac     1920

gccugugcgg gugacucugg aggccccaug gugacccuga auagagaaag aggccagugg     1980

uaccuggugg gcacuguguc cuggggugau gacuguggga agaaggaccg cuacggagua     2040

uacucuuaca uccaccacaa caaggacugg auccagaggg ucaccggagu gaggaacuga     2100


<210>  8110
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8110
augcgcuggc ugcuccugua cuacgcccug ugcuucagcc ucuccaaggc cagcgcgcac       60

accguggagc ugaacaacau guucggccag auccaguccc ccggguaccc ggacagcuac      120

cccuccgaca gcgaggucac cuggaacauc acggugcccg acggcuuccg gaucaagcug      180

uacuucaugc acuucaaccu cgaguccagc uaccugugcg aguacgacua cgugaagguc      240

gagaccgagg accaggugcu ggccaccuuc ugcgggcgcg agaccacgga caccgagcag      300

acccccggcc aggagguggu ccucuccccg gggagcuuca uguccaucac cuuccggagc      360

gacuucucca acgaggagcg cuucacgggc uucgacgccc acuacauggc cguggacgug      420

gacgagugca aggagcggga ggacgaggag cugagcugcg accacuacug ccacaacuac      480

aucggcgggu acuacugcuc cugccgcuuc ggcuacaucc ugcacaccga caaccggacc      540

ugccgcgucg agugcagcga caaccucuuc acccagcgga cgggggugau caccuccccc      600

gacuucccca accccuaccc caagagcucc gagugccugu acaccaucga gcuggaggag      660

ggcuucaugg ugaaccucca guucgaggac aucuucgaca ucgaggacca ccccgagguc      720

cccugccccu acgacuacau caagaucaag guggggccga aggugcuggg ccccuucugc      780

ggcgagaagg cccccgagcc caucagcacc cagagccacu ccguccugau ccucuuccac      840

agcgacaacu ccggggagaa ccgcggcugg cggcugagcu accgcgcggc cgggaacgag      900

ugcccggagc ugcagccgcc cgugcacggc aagaucgagc ccucccaggc caaguacuuc      960

uucaaggacc aggugcucgu cagcugcgac acgggcuaca aggugcugaa ggacaacgug     1020

gagauggaca ccuuccagau cgagugccug aaggacggga ccugguccaa caagaucccg     1080

accugcaaga ucgucgacug ccgggccccc ggcgagcucg agcacgggcu gaucacguuc     1140

agcacccgca acaaccugac caccuacaag uccgagauca aguacagcug ccaggagccc     1200

uacuacaaga ugcucaacaa caacacgggc aucuacacgu gcuccgcgca gggggugugg     1260

augaacaagg ugcugggccg gagccugccg accugccucc ccgucugcgg ccugcccaag     1320

uucucccgca agcugauggc ccggaucuuc aacgggcgcc ccgcccagaa gggcaccacc     1380

cccuggaucg ccaugcucag ccaccugaac gggcagccgu ucugcggcgg gucccugcuc     1440

ggcagcuccu ggaucgugac cgccgcgcac ugccugcacc agagccugga ccccgaggac     1500

cccacccucc gggacuccga ccugcugagc ccgagcgacu ucaagaucau ccucggcaag     1560

cacuggcgcc ugcgguccga cgagaacgag cagcaccugg gggucaagca caccacgcuc     1620

cacccccagu acgaccccaa caccuucgag aacgacgugg cccuggugga gcugcucgag     1680

agccccgucc ugaacgccuu cgugaugccg aucugccugc ccgagggccc ccagcaggag     1740

ggggccaugg ugaucgucuc cggcuggggg aagcaguucc ugcagcgcuu ccccgagacc     1800

cucauggaga ucgagauccc gaucguggac cacagcacgu gccagaaggc cuacgcgccc     1860

cugaagaaga aggugacccg cgacaugauc ugcgccggcg agaaggaggg cgggaaggac     1920

gccugcgccg gcgacuccgg gggccccaug gucacccuga accgggagcg cggccagugg     1980

uaccucgugg ggaccgugag cuggggcgac gacugcggga agaaggaccg guacggcguc     2040

uacuccuaca uccaccacaa caaggacugg auccagcgcg ugaccggggu gcggaacuga     2100


<210>  8111
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8111
augcgcuggc uccuccucua cuacgcccuc ugcuucuccc ucuccaaggc cuccgcccac       60

accgucgagc ucaacaacau guucggccag auccaguccc ccggcuaccc cgacuccuac      120

cccuccgacu ccgaggucac cuggaacauc accguccccg acggcuuccg caucaagcuc      180

uacuucaugc acuucaaccu cgaguccucc uaccucugcg aguacgacua cgucaagguc      240

gagaccgagg accagguccu cgccaccuuc ugcggccgcg agaccaccga caccgagcag      300

acccccggcc aggaggucgu ccucuccccc ggcuccuuca uguccaucac cuuccgcucc      360

gacuucucca acgaggagcg cuucaccggc uucgacgccc acuacauggc cgucgacguc      420

gacgagugca aggagcgcga ggacgaggag cucuccugcg accacuacug ccacaacuac      480

aucggcggcu acuacugcuc cugccgcuuc ggcuacaucc uccacaccga caaccgcacc      540

ugccgcgucg agugcuccga caaccucuuc acccagcgca ccggcgucau caccuccccc      600

gacuucccca accccuaccc caaguccucc gagugccucu acaccaucga gcucgaggag      660

ggcuucaugg ucaaccucca guucgaggac aucuucgaca ucgaggacca ccccgagguc      720

cccugccccu acgacuacau caagaucaag gucggcccca agguccucgg ccccuucugc      780

ggcgagaagg cccccgagcc caucuccacc cagucccacu ccguccucau ccucuuccac      840

uccgacaacu ccggcgagaa ccgcggcugg cgccucuccu accgcgccgc cggcaacgag      900

ugccccgagc uccagccccc cguccacggc aagaucgagc ccucccaggc caaguacuuc      960

uucaaggacc agguccucgu cuccugcgac accggcuaca agguccucaa ggacaacguc     1020

gagauggaca ccuuccagau cgagugccuc aaggacggca ccugguccaa caagaucccc     1080

accugcaaga ucgucgacug ccgcgccccc ggcgagcucg agcacggccu caucaccuuc     1140

uccacccgca acaaccucac caccuacaag uccgagauca aguacuccug ccaggagccc     1200

uacuacaaga ugcucaacaa caacaccggc aucuacaccu gcuccgccca gggcgucugg     1260

augaacaagg uccucggccg cucccucccc accugccucc ccgucugcgg ccuccccaag     1320

uucucccgca agcucauggc ccgcaucuuc aacggccgcc ccgcccagaa gggcaccacc     1380

cccuggaucg ccaugcucuc ccaccucaac ggccagcccu ucugcggcgg cucccuccuc     1440

ggcuccuccu ggaucgucac cgccgcccac ugccuccacc agucccucga ccccgaggac     1500

cccacccucc gcgacuccga ccuccucucc cccuccgacu ucaagaucau ccucggcaag     1560

cacuggcgcc uccgcuccga cgagaacgag cagcaccucg gcgucaagca caccacccuc     1620

cacccccagu acgaccccaa caccuucgag aacgacgucg cccucgucga gcuccucgag     1680

ucccccgucc ucaacgccuu cgucaugccc aucugccucc ccgagggccc ccagcaggag     1740

ggcgccaugg ucaucgucuc cggcuggggc aagcaguucc uccagcgcuu ccccgagacc     1800

cucauggaga ucgagauccc caucgucgac cacuccaccu gccagaaggc cuacgccccc     1860

cucaagaaga aggucacccg cgacaugauc ugcgccggcg agaaggaggg cggcaaggac     1920

gccugcgccg gcgacuccgg cggccccaug gucacccuca accgcgagcg cggccagugg     1980

uaccucgucg gcaccgucuc cuggggcgac gacugcggca agaaggaccg cuacggcguc     2040

uacuccuaca uccaccacaa caaggacugg auccagcgcg ucaccggcgu ccgcaacuga     2100


<210>  8112
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8112
augagauggc ugcuccuuua cuaugcccug ugcuucagcu uguccaaggc uucugcacac       60

accguggagu uaaacaauau guuuggccag auccaaucac ccggguaccc ugacaguuau      120

ccaagcgauu ccgaagucac auggaacauu acuguuccgg acggauucag gauaaaacug      180

uacuuuaugc auuucaaucu agagucuucg uaucucugug aauacgauua ugugaaggua      240

gagacggaag accaggugcu ggccaccuuu ugcggucggg agacaacuga uaccgagcag      300

acacccggcc aggaagucgu gcuuucaccu gggagcuuca ugaguaucac cuuucgcucc      360

gacuucucua acgaggaacg auuuacugga uucgaugcgc acuacauggc uguugacgug      420

gaugagugua aagagcguga agacgaggaa cugagcugcg aucauuacug ucacaauuau      480

auuggcgguu acuauugcuc cuguagauuu ggguacaucu ugcauacaga caacaggacc      540

ugccgggucg aguguucaga uaaucucuuc acgcaacgca cuggagugau uaccagucca      600

gacuuuccca acccuuaucc aaagagcucu gaaugccugu acacaaucga gcuggaggaa      660

ggcuucaugg uaaaucucca guucgaggac auauuugaua ucgaagacca ccccgagguu      720

ccuuguccau augauuacau uaaaaucaag gugggcccga aggucuuagg gcccuucugc      780

ggagaaaaag ccccugagcc aauuuccacu cagucacaca gcgugcugau ccuuuuucau      840

agugacaacu cuggugagaa uagaggcugg agguuguccu accgggcagc cgggaacgaa      900

ugccccgagc ugcagccucc agugcacgga aagauagaac ccagccaagc uaaauauuuc      960

uuuaaggauc agguccuagu uucgugugac accggcuaca aagugcucaa ggauaaugua     1020

gagauggaca cauuccagau ugaaugccug aaggauggua ccuggucuaa caaaaucccg     1080

acguguaaga uuguggacug ccgcgcaccu ggggagcuug agcauggacu gaucacuuuu     1140

uccacacgaa auaacuugac cacuuauaaa ucagaaauca aguacaguug ucaggagccc     1200

uauuacaaaa ugcucaacaa uaacacaggc auuuauaccu gcagcgccca aggcgucugg     1260

augaauaagg ugcuggggag auccuuacca acgugucugc cuguuugcgg acuccccaaa     1320

uucucuagga aacuuauggc ucggauauuu aacggucguc cagcccagaa gggcaccaca     1380

cccuggaucg cgaugcugag ccacuugaau gggcagccuu ucuguggagg cucacuacug     1440

gguaguuccu ggauugugac ugcagcccac ugccuccauc aaagccugga uccagaagac     1500

ccgacccuuc gcgacucuga ucuguuguca cccagugacu uuaaaaucau acucgggaag     1560

cacuggagac ugaggagcga ugagaacgag cagcauuuag gcgucaaaca cacaacucug     1620

cauccucagu acgacccaaa uaccuucgaa aacgaugugg cucuaguaga gcuccuggaa     1680

ucccccguuc uuaaugccuu ugugaugccu auuuguuugc cagagggacc ccagcaagaa     1740

ggcgcaaugg ucaucguguc ugggugggga aagcaguucc ugcagcgguu cccggagaca     1800

cucauggaga ucgaaauucc uaucgucgac cacucgaccu gccagaaggc uuacgcccca     1860

cugaagaaga aagugacucg agauaugauu ugcgcgggug agaaggaagg cgggaaagac     1920

gccugugcag gagauagcgg cggucccaug guuacgcuua accgcgagag agggcaaugg     1980

uaucuggugg gcacaguauc cuggggagac gauugcggca agaaagacag guacgggguc     2040

uauucauaca uacaccauaa uaaggauugg auccagcggg ugaccggagu ucgcaacuga     2100


<210>  8113
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8113
augagauggc ugcugcugua cuacgcccug ugcuucagcc ugagcaaggc cagcgcccac       60

accguggagc ugaacaacau guucggccag auccagagcc ccggcuaccc cgacagcuac      120

cccagcgaca gcgaggugac cuggaacauc accgugcccg acggcuucag aaucaagcug      180

uacuucaugc acuucaaccu ggagagcagc uaccugugcg aguacgacua cgugaaggug      240

gagaccgagg accaggugcu ggccaccuuc ugcggcagag agaccaccga caccgagcag      300

acccccggcc aggagguggu gcugagcccc ggcagcuuca ugagcaucac cuucagaagc      360

gacuucagca acgaggagag auucaccggc uucgacgccc acuacauggc cguggacgug      420

gacgagugca aggagagaga ggacgaggag cugagcugcg accacuacug ccacaacuac      480

aucggcggcu acuacugcag cugcagauuc ggcuacaucc ugcacaccga caacagaacc      540

ugcagagugg agugcagcga caaccuguuc acccagagaa ccggcgugau caccagcccc      600

gacuucccca accccuaccc caagagcagc gagugccugu acaccaucga gcuggaggag      660

ggcuucaugg ugaaccugca guucgaggac aucuucgaca ucgaggacca ccccgaggug      720

cccugccccu acgacuacau caagaucaag gugggcccca aggugcuggg ccccuucugc      780

ggcgagaagg cccccgagcc caucagcacc cagagccaca gcgugcugau ccuguuccac      840

agcgacaaca gcggcgagaa cagaggcugg agacugagcu acagagccgc cggcaacgag      900

ugccccgagc ugcagccccc cgugcacggc aagaucgagc ccagccaggc caaguacuuc      960

uucaaggacc aggugcuggu gagcugcgac accggcuaca aggugcugaa ggacaacgug     1020

gagauggaca ccuuccagau cgagugccug aaggacggca ccuggagcaa caagaucccc     1080

accugcaaga ucguggacug cagagccccc ggcgagcugg agcacggccu gaucaccuuc     1140

agcaccagaa acaaccugac caccuacaag agcgagauca aguacagcug ccaggagccc     1200

uacuacaaga ugcugaacaa caacaccggc aucuacaccu gcagcgccca gggcgugugg     1260

augaacaagg ugcugggcag aagccugccc accugccugc ccgugugcgg ccugcccaag     1320

uucagcagaa agcugauggc cagaaucuuc aacggcagac ccgcccagaa gggcaccacc     1380

cccuggaucg ccaugcugag ccaccugaac ggccagcccu ucugcggcgg cagccugcug     1440

ggcagcagcu ggaucgugac cgccgcccac ugccugcacc agagccugga ccccgaggac     1500

cccacccuga gagacagcga ccugcugagc cccagcgacu ucaagaucau ccugggcaag     1560

cacuggagac ugagaagcga cgagaacgag cagcaccugg gcgugaagca caccacccug     1620

cacccccagu acgaccccaa caccuucgag aacgacgugg cccuggugga gcugcuggag     1680

agccccgugc ugaacgccuu cgugaugccc aucugccugc ccgagggccc ccagcaggag     1740

ggcgccaugg ugaucgugag cggcuggggc aagcaguucc ugcagagauu ccccgagacc     1800

cugauggaga ucgagauccc caucguggac cacagcaccu gccagaaggc cuacgccccc     1860

cugaagaaga aggugaccag agacaugauc ugcgccggcg agaaggaggg cggcaaggac     1920

gccugcgccg gcgacagcgg cggccccaug gugacccuga acagagagag aggccagugg     1980

uaccuggugg gcaccgugag cuggggcgac gacugcggca agaaggacag auacggcgug     2040

uacagcuaca uccaccacaa caaggacugg auccagagag ugaccggcgu gagaaacuga     2100


<210>  8114
<211>  2100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_MASP-1__Homo_sapiens__CCDS33907.1

<400>  8114
augagauggc ugcuccugua cuaugcccuu ugcuucagcc uguccaaggc uucugcccac       60

accguggagc ucaacaauau guuuggccag auccaaagcc ccggguaccc ugacuccuau      120

ccgucugaua gcgaagucac auggaacauu acgguucccg acggauuccg gaucaaacug      180

uacuuuaugc auuucaaucu ugaguccucu uaucugugug aauacgauua ugugaaggug      240

gagaccgaag accagguccu cgcgacauuu ugcggccgcg agaccacaga uaccgagcag      300

acaccugggc aggaaguggu ucugagcccc ggauccuuca ugagcauuac cuuuagaucu      360

gacuucucca acgaggaacg guuuacgggc uucgaugcuc acuacauggc cguggacguc      420

gaugagugua aagagcgcga agacgaggaa cugagcugcg aucauuacug ucacaauuau      480

aucgggggau acuauugcuc uuguagauuu ggcuacauuc uccauaccga caaccggaca      540

ugccgcgugg aguguuccga uaaucuguuc acccaaagaa caggcguuau caccagcccu      600

gacuuuccca acccuuaucc gaagucuucc gaaugccuuu acacgaucga gcuggaggaa      660

ggguucaugg ugaaucucca guucgaggac auuuuugaua ucgaagacca ccccgagguc      720

ccuugucccu augauuacau uaaaaucaag gugggaccua aggugcuggg ccccuucugc      780

ggggaaaaag ccccggagcc uauuagcaca cagucccacu cuguccuuau ccuguuucau      840

agcgacaacu ccggagagaa ucggggcugg cgccucagcu acagagcugc cgggaacgaa      900

ugccccgagc ugcagccucc cguucacgga aagauugaac ccucucaagc uaaauauuuc      960

uuuaaggauc aggugcuggu guccugugac accggcuaca aaguccucaa ggauaaugug     1020

gagauggaca cauuccagau cgaaugccug aaggauggca ccuggagcaa caaaaucccu     1080

accuguaaga uuguugacug ccgggccccg ggggagcuug agcauggacu gaucacauuu     1140

ucuacgcgca auaaccucac cacauauaaa agcgaaauua aguacuccug ucaggagccc     1200

uauuacaaaa ugcugaacaa uaacaccggc aucuauacau gcucugcgca aggggugugg     1260

augaauaagg uccuuggaag aagccugccu accugucucc ccgugugcgg ccugccuaaa     1320

uucucccgga agcugauggc ccgcauuuuu aacgggagac ccgcucagaa gggaacgaca     1380

ccguggaucg ccaugcucag ccaccugaau ggccagccuu ucuguggcgg gucucuucug     1440

ggauccagcu ggaucguuac cgcugcccac ugccuccauc aaucucugga ucccgaagac     1500

ccuacccuuc gggacuccga ucugcucagc cccuccgacu uuaaaauuau ccugggcaag     1560

cacuggagac ugcgcucuga ugagaacgag cagcaucucg gggugaaaca cacaacccug     1620

cauccucagu acgaccccaa uacauucgaa aacgaugucg cgcuugugga gcugcucgaa     1680

agcccggucc ugaaugccuu ugugaugccu auuugucugc ccgagggacc ccagcaagaa     1740

ggcgcuaugg uuaucguguc cggguggggc aagcaguucc uucagcgguu cccugagacg     1800

cucauggaga uugaaauccc gaucgucgac cacucuaccu gccagaaagc cuacgcuccc     1860

cugaagaaga aagugacaag agauaugauu ugcgccggag agaaggaagg cgggaaagac     1920

gccugugcug gagauagcgg cgggccuaug guuacccuga accgcgagcg gggacaaugg     1980

uaucucgugg gcacagucuc cuggggcgac gauugcggga agaaagacag auacggagug     2040

uauagcuaca uccaccauaa uaaggauugg auucagcgcg ugaccggcgu ucggaacuga     2100


<210>  8115
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MASP-2__Homo_sapiens__O00187

<400>  8115

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  8116
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8116
augaggcugc ugacccuccu gggccuucug uguggcucgg uggccacccc cuugggcccg       60

aaguggccug aaccuguguu cgggcgccug gcaucccccg gcuuuccagg ggaguaugcc      120

aaugaccagg agcggcgcug gacccugacu gcaccccccg gcuaccgccu gcgccucuac      180

uucacccacu ucgaccugga gcucucccac cucugcgagu acgacuucgu caagcugagc      240

ucgggggcca aggugcuggc cacgcugugc gggcaggaga gcacagacac ggagcgggcc      300

ccuggcaagg acacuuucua cucgcugggc uccagccugg acauuaccuu ccgcuccgac      360

uacuccaacg agaagccguu cacgggguuc gaggccuucu augcagccga ggacauugac      420

gagugccagg uggccccggg agaggcgccc accugcgacc accacugcca caaccaccug      480

ggcgguuucu acugcuccug ccgcgcaggc uacguccugc accguaacaa gcgcaccugc      540

ucagcccugu gcuccggcca ggucuucacc cagaggucug gggagcucag cagcccugaa      600

uacccacggc cguaucccaa acucuccagu ugcacuuaca gcaucagccu ggaggagggg      660

uucaguguca uucuggacuu uguggagucc uucgaugugg agacacaccc ugaaacccug      720

ugucccuacg acuuucucaa gauucaaaca gacagagaag aacauggccc auucuguggg      780

aagacauugc cccacaggau ugaaacaaaa agcaacacgg ugaccaucac cuuugucaca      840

gaugaaucag gagaccacac aggcuggaag auccacuaca cgagcacagc gcagccuugc      900

ccuuauccga uggcgccacc uaauggccac guuucaccug ugcaagccaa auacauccug      960

aaagacagcu ucuccaucuu uugcgagacu ggcuaugagc uucugcaagg ucacuugccc     1020

cugaaauccu uuacugcagu uugucagaaa gauggaucuu gggaccggcc aaugcccgcg     1080

ugcagcauug uugacugugg cccuccugau gaucuaccca guggccgagu ggaguacauc     1140

acagguccug gagugaccac cuacaaagcu gugauucagu acagcuguga agagaccuuc     1200

uacacaauga aagugaauga ugguaaauau gugugugagg cugauggauu cuggacgagc     1260

uccaaaggag aaaaaucacu cccagucugu gagccuguuu guggacuauc agcccgcaca     1320

acaggagggc guauauaugg agggcaaaag gcaaaaccug gugauuuucc uuggcaaguc     1380

cugauauuag guggaaccac agcagcaggu gcacuuuuau augacaacug gguccuaaca     1440

gcugcucaug ccgucuauga gcaaaaacau gaugcauccg cccuggacau ucgaaugggc     1500

acccugaaaa gacuaucacc ucauuauaca caagccuggu cugaagcugu uuuuauacau     1560

gaagguuaua cucaugaugc uggcuuugac aaugacauag cacugauuaa auugaauaac     1620

aaaguuguaa ucaauagcaa caucacgccu auuugucugc caagaaaaga agcugaaucc     1680

uuuaugagga cagaugacau uggaacugca ucuggauggg gauuaaccca aagggguuuu     1740

cuugcuagaa aucuaaugua ugucgacaua ccgauuguug accaucaaaa auguacugcu     1800

gcauaugaaa agccacccua uccaagggga aguguaacug cuaacaugcu uugugcuggc     1860

uuagaaagug ggggcaagga cagcugcaga ggugacagcg gaggggcacu gguguuucua     1920

gauagugaaa cagagaggug guuuguggga ggaauagugu ccugggguuc caugaauugu     1980

ggggaagcag gucaguaugg agucuacaca aaaguuauua acuauauucc cuggaucgag     2040

aacauaauua gugauuuuua a                                               2061


<210>  8117
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8117
augcgccugc ucacccugcu gggccuccug ugcgggagcg uggccacgcc ccugggcccg       60

aaguggcccg agcccgucuu cgggcggcuc gccucccccg gcuucccggg ggaguacgcg      120

aacgaccagg agcgccggug gacccugacc gccccgcccg gcuaccgccu gcggcucuac      180

uucacccacu ucgaccugga gcugagccac cucugcgagu acgacuucgu gaagcugucc      240

agcggcgcca aggugcuggc cacccucugc gggcaggagu ccacggacac cgagcgcgcc      300

cccggcaagg acaccuucua cagccugggg uccagccugg acaucaccuu ccgguccgac      360

uacagcaacg agaagcccuu cacgggcuuc gaggcguucu acgccgccga ggacaucgac      420

gagugccagg ucgcccccgg ggaggcgccg accugcgacc accacugcca caaccaccuc      480

ggcggcuucu acugcuccug ccgcgccggg uacgugcugc accggaacaa gcggaccugc      540

agcgcccugu gcuccggcca gguguucacc cagcgcagcg gggagcucuc cagccccgag      600

uacccccgcc ccuaccccaa gcuguccagc ugcacguacu ccaucagccu ggaggagggc      660

uucagcguca uccucgacuu cguggagucc uucgacgugg agacccaccc cgagacccug      720

ugcccguacg acuuccugaa gauccagacc gaccgggagg agcacggccc cuucugcggg      780

aagacgcucc cccaccgcau cgagaccaag agcaacaccg ucaccaucac guucgugacc      840

gacgaguccg gcgaccacac cggguggaag auccacuaca ccagcacggc ccagcccugc      900

ccguacccca uggccccgcc caacggccac gugucccccg uccaggcgaa guacauccug      960

aaggacagcu ucuccaucuu cugcgagacc ggguacgagc ugcuccaggg ccaccucccc     1020

cucaagagcu ucaccgccgu gugccagaag gacggcuccu gggaccggcc caugcccgcc     1080

ugcagcaucg uggacugcgg gccgcccgac gaccugcccu ccggccgcgu cgaguacauc     1140

accgggccgg gcgugacgac cuacaaggcc gugauccagu acagcugcga ggagaccuuc     1200

uacaccauga aggucaacga cgggaaguac gugugcgagg ccgacggcuu cuggacgucc     1260

agcaagggcg agaagucccu gcccgugugc gagcccgucu gcgggcugag cgcgcggacc     1320

accggcgggc gcaucuacgg cgggcagaag gccaagcccg gcgacuuccc guggcagguc     1380

cugauccugg gcgggaccac ggccgccggc gcccugcucu acgacaacug ggugcugacc     1440

gcggcccacg ccguguacga gcagaagcac gacgccuccg cccuggacau ccggaugggg     1500

acccucaagc gccugagccc ccacuacacc caggcguggu ccgaggccgu guucauccac     1560

gagggcuaca cccacgacgc cggcuucgac aacgacaucg cccugaucaa gcucaacaac     1620

aaggucguga ucaacagcaa caucacgccc aucugccugc cccggaagga ggcggagagc     1680

uucaugcgca ccgacgacau cgggaccgcc uccggcuggg ggcugaccca gcgcggcuuc     1740

cucgcccgga accugaugua cguggacauc ccgaucgucg accaccagaa gugcacggcc     1800

gccuacgaga agccgcccua cccccgcggg agcgugaccg cgaacaugcu gugcgccggc     1860

cuggaguccg gcgggaagga cagcugccgg ggcgacuccg ggggcgcccu cguguuccug     1920

gacagcgaga ccgagcgcug guucgucggg ggcaucgugu ccuggggcag caugaacugc     1980

ggggaggccg gccaguacgg gguguacacc aaggucauca acuacauccc cuggaucgag     2040

aacaucaucu ccgacuucug a                                               2061


<210>  8118
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8118
augcgccucc ucacccuccu cggccuccuc ugcggcuccg ucgccacccc ccucggcccc       60

aaguggcccg agcccgucuu cggccgccuc gccucccccg gcuuccccgg cgaguacgcc      120

aacgaccagg agcgccgcug gacccucacc gccccccccg gcuaccgccu ccgccucuac      180

uucacccacu ucgaccucga gcucucccac cucugcgagu acgacuucgu caagcucucc      240

uccggcgcca agguccucgc cacccucugc ggccaggagu ccaccgacac cgagcgcgcc      300

cccggcaagg acaccuucua cucccucggc uccucccucg acaucaccuu ccgcuccgac      360

uacuccaacg agaagcccuu caccggcuuc gaggccuucu acgccgccga ggacaucgac      420

gagugccagg ucgcccccgg cgaggccccc accugcgacc accacugcca caaccaccuc      480

ggcggcuucu acugcuccug ccgcgccggc uacguccucc accgcaacaa gcgcaccugc      540

uccgcccucu gcuccggcca ggucuucacc cagcgcuccg gcgagcucuc cucccccgag      600

uacccccgcc ccuaccccaa gcucuccucc ugcaccuacu ccaucucccu cgaggagggc      660

uucuccguca uccucgacuu cgucgagucc uucgacgucg agacccaccc cgagacccuc      720

ugccccuacg acuuccucaa gauccagacc gaccgcgagg agcacggccc cuucugcggc      780

aagacccucc cccaccgcau cgagaccaag uccaacaccg ucaccaucac cuucgucacc      840

gacgaguccg gcgaccacac cggcuggaag auccacuaca ccuccaccgc ccagcccugc      900

cccuacccca uggccccccc caacggccac gucucccccg uccaggccaa guacauccuc      960

aaggacuccu ucuccaucuu cugcgagacc ggcuacgagc uccuccaggg ccaccucccc     1020

cucaaguccu ucaccgccgu cugccagaag gacggcuccu gggaccgccc caugcccgcc     1080

ugcuccaucg ucgacugcgg cccccccgac gaccuccccu ccggccgcgu cgaguacauc     1140

accggccccg gcgucaccac cuacaaggcc gucauccagu acuccugcga ggagaccuuc     1200

uacaccauga aggucaacga cggcaaguac gucugcgagg ccgacggcuu cuggaccucc     1260

uccaagggcg agaagucccu ccccgucugc gagcccgucu gcggccucuc cgcccgcacc     1320

accggcggcc gcaucuacgg cggccagaag gccaagcccg gcgacuuccc cuggcagguc     1380

cucauccucg gcggcaccac cgccgccggc gcccuccucu acgacaacug gguccucacc     1440

gccgcccacg ccgucuacga gcagaagcac gacgccuccg cccucgacau ccgcaugggc     1500

acccucaagc gccucucccc ccacuacacc caggccuggu ccgaggccgu cuucauccac     1560

gagggcuaca cccacgacgc cggcuucgac aacgacaucg cccucaucaa gcucaacaac     1620

aaggucguca ucaacuccaa caucaccccc aucugccucc cccgcaagga ggccgagucc     1680

uucaugcgca ccgacgacau cggcaccgcc uccggcuggg gccucaccca gcgcggcuuc     1740

cucgcccgca accucaugua cgucgacauc cccaucgucg accaccagaa gugcaccgcc     1800

gccuacgaga agccccccua cccccgcggc uccgucaccg ccaacaugcu cugcgccggc     1860

cucgaguccg gcggcaagga cuccugccgc ggcgacuccg gcggcgcccu cgucuuccuc     1920

gacuccgaga ccgagcgcug guucgucggc ggcaucgucu ccuggggcuc caugaacugc     1980

ggcgaggccg gccaguacgg cgucuacacc aaggucauca acuacauccc cuggaucgag     2040

aacaucaucu ccgacuucug a                                               2061


<210>  8119
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8119
augagacugc ucacccuucu gggcuuguua ugcgggagcg uggccacacc ccugggaccu       60

aaguggccag agccggucuu cgguaggcua gcuucccccg gcuuuccugg ggaauacgca      120

aacgaccagg agcggcgcug gacucucacg gccccacccg gauaucgacu gcgucuuuac      180

uucacccacu uugaucugga auugucucau cucugugagu augacuucgu uaaacuguca      240

aguggcgcga aggugcuggc uacacucugc ggucaagaaa gcacugauac cgagagagcc      300

ccugggaaag acacauuuua cuccuuagga ucuucgcugg auaucaccuu caggucagac      360

uauagcaaug agaagccauu uacuggcuuc gaagcauuuu acgccgcuga ggauauugac      420

gaaugucagg uagcacccgg cgaggccccu acaugcgauc accauuguca caaccaucuu      480

gggggauucu auugcaguug ucgggcuggu uacguguugc accgcaauaa aagaaccugc      540

uccgcccugu guucuggcca ggucuuuacg cagaggagcg gggagcuauc cucaccagaa      600

uacccgcggc ccuauccuaa gcucaguagc ugcacuuacu cuauaucccu ggaggaagga      660

uucucaguga uccuugacuu uguugagagc uucgaugugg aaacccaccc agagacacug      720

ugucccuaug acuucuugaa gauucaaacu gaucgcgagg aacauggccc uuuuugcggu      780

aaaacccucc cacaccgaau cgagacaaag aguaacaccg ucacgauuac uuucgugaca      840

gacgaaucug gggaccauac cggauggaaa auccacuaca cuuccacagc gcagcccugc      900

ccguauccua uggcaccccc aaauggccac guaagcccug uucaggccaa guacauacug      960

aaagauucgu uuucuaucuu cugugagacc ggcuaugaau uacugcaggg gcaucucccc     1020

cuuaaguccu uuacggcugu gugccaaaag gacggaucau gggauagacc aaugcccgcc     1080

uguaguauug ucgacugcgg uccuccagau gaccugccga gcggcagggu ggaguacauc     1140

accgggcccg gagugacaac uuacaaagca gucauucagu auuccuguga ggaaaccuuc     1200

uacacaauga agguuaacga uggcaaauau gugugcgagg cugacgguuu uuggacuucu     1260

agcaaggggg aaaaaucauu gccuguaugu gagccagugu gcggccuaag ugcccggacc     1320

acaggaggcc guaucuacgg gggacagaag gcgaaacccg gugauuuccc uuggcagguc     1380

cugauacucg gcgggaccac ugccgcagga gcucugcuuu augacaauug ggugcugacg     1440

gccgcucacg ccguuuacga acaaaagcau gaugcauccg ccuuggacau ucgcaugggc     1500

acacucaaga gacugagccc acacuauacc caggcuuggu cugaggcggu guuuauccau     1560

gaggguuaca cucacgacgc aggguucgau aacgacauug ccuuaaucaa acugaauaac     1620

aaggucguga ucaauucaaa cauuaccccc auaugucuac cgaggaaaga agcugagagu     1680

uuuaugcgga cagaugacau cggcaccgcc agcggauggg gccucacuca gcgaggguuc     1740

cuggcacgca aucuuaugua cguagauauu ccuaucguug accaccaaaa gugcacagcc     1800

gcuuaugaaa aaccacccua cccuagagga uccgugacgg ccaacauguu gugugcaggu     1860

cuggagucug gcgggaagga uucgugcagg ggagacagcg gcggugcgcu cgucuuucug     1920

gauuccgaga ccgaacggug guucgucggg ggcauagugu cauggggaag uaugaauugc     1980

ggcgaggcug ggcaguaugg aguguacacu aagguuauua acuauauccc cuggaucgaa     2040

aacauuaucu cugacuucug a                                               2061


<210>  8120
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8120
augagacugc ugacccugcu gggccugcug ugcggcagcg uggccacccc ccugggcccc       60

aaguggcccg agcccguguu cggcagacug gccagccccg gcuuccccgg cgaguacgcc      120

aacgaccagg agagaagaug gacccugacc gccccccccg gcuacagacu gagacuguac      180

uucacccacu ucgaccugga gcugagccac cugugcgagu acgacuucgu gaagcugagc      240

agcggcgcca aggugcuggc cacccugugc ggccaggaga gcaccgacac cgagagagcc      300

cccggcaagg acaccuucua cagccugggc agcagccugg acaucaccuu cagaagcgac      360

uacagcaacg agaagcccuu caccggcuuc gaggccuucu acgccgccga ggacaucgac      420

gagugccagg uggcccccgg cgaggccccc accugcgacc accacugcca caaccaccug      480

ggcggcuucu acugcagcug cagagccggc uacgugcugc acagaaacaa gagaaccugc      540

agcgcccugu gcagcggcca gguguucacc cagagaagcg gcgagcugag cagccccgag      600

uaccccagac ccuaccccaa gcugagcagc ugcaccuaca gcaucagccu ggaggagggc      660

uucagcguga uccuggacuu cguggagagc uucgacgugg agacccaccc cgagacccug      720

ugccccuacg acuuccugaa gauccagacc gacagagagg agcacggccc cuucugcggc      780

aagacccugc cccacagaau cgagaccaag agcaacaccg ugaccaucac cuucgugacc      840

gacgagagcg gcgaccacac cggcuggaag auccacuaca ccagcaccgc ccagcccugc      900

cccuacccca uggccccccc caacggccac gugagccccg ugcaggccaa guacauccug      960

aaggacagcu ucagcaucuu cugcgagacc ggcuacgagc ugcugcaggg ccaccugccc     1020

cugaagagcu ucaccgccgu gugccagaag gacggcagcu gggacagacc caugcccgcc     1080

ugcagcaucg uggacugcgg cccccccgac gaccugccca gcggcagagu ggaguacauc     1140

accggccccg gcgugaccac cuacaaggcc gugauccagu acagcugcga ggagaccuuc     1200

uacaccauga aggugaacga cggcaaguac gugugcgagg ccgacggcuu cuggaccagc     1260

agcaagggcg agaagagccu gcccgugugc gagcccgugu gcggccugag cgccagaacc     1320

accggcggca gaaucuacgg cggccagaag gccaagcccg gcgacuuccc cuggcaggug     1380

cugauccugg gcggcaccac cgccgccggc gcccugcugu acgacaacug ggugcugacc     1440

gccgcccacg ccguguacga gcagaagcac gacgccagcg cccuggacau cagaaugggc     1500

acccugaaga gacugagccc ccacuacacc caggccugga gcgaggccgu guucauccac     1560

gagggcuaca cccacgacgc cggcuucgac aacgacaucg cccugaucaa gcugaacaac     1620

aaggugguga ucaacagcaa caucaccccc aucugccugc ccagaaagga ggccgagagc     1680

uucaugagaa ccgacgacau cggcaccgcc agcggcuggg gccugaccca gagaggcuuc     1740

cuggccagaa accugaugua cguggacauc cccaucgugg accaccagaa gugcaccgcc     1800

gccuacgaga agccccccua ccccagaggc agcgugaccg ccaacaugcu gugcgccggc     1860

cuggagagcg gcggcaagga cagcugcaga ggcgacagcg gcggcgcccu gguguuccug     1920

gacagcgaga ccgagagaug guucgugggc ggcaucguga gcuggggcag caugaacugc     1980

ggcgaggccg gccaguacgg cguguacacc aaggugauca acuacauccc cuggaucgag     2040

aacaucauca gcgacuucug a                                               2061


<210>  8121
<211>  2061
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_MASP-2__Homo_sapiens__CCDS123.1

<400>  8121
augagacugc ucacccugcu uggccugcuc ugcgggagcg uggccacacc ccugggaccu       60

aaguggccgg agcccgucuu cggccggcuu gcuuccccug gguuucccgg agaauacgcc      120

aacgaccagg agcgcagaug gacgcugacc gcgccucccg gcuaucggcu ccgccuguac      180

uucacacacu uugaucugga acucucucau cugugugagu augacuucgu uaaacuuagc      240

uccggggcua aggugcuggc cacccucugc ggacaagaau cuacagauac cgagagagcc      300

ccuggcaaag acacauuuua cagccugggc uccucucuug auaucaccuu ccggagcgac      360

uauuccaaug agaagccguu uacgggguuc gaggcuuuuu acgccgcuga agauauugac      420

gaaugucagg uggcccccgg agaggcgccu accugcgauc accauuguca caaccaucug      480

ggcggguucu auugcagcug ucgcgccgga uacguccucc acagaaauaa acggacaugc      540

ucugcucugu guuccggcca gguguuuacc cagcgcagcg gggagcuguc uucccccgaa      600

uacccuagac ccuauccgaa gcucagcucu ugcacauacu ccaucagccu ggaggaagga      660

uucuccguua uucuugacuu uguggagucu uucgaugucg aaacccaccc ugagacgcug      720

ugucccuaug acuuccucaa gauccaaaca gaucgggagg aacauggccc uuuuugcggc      780

aaaacccugc cccaccgcau ugagacaaag agcaacaccg ugaccaucac auucguuacg      840

gacgaauccg gggaccauac cggauggaaa auccacuaca caagcaccgc ccagcccugc      900

ccuuauccga uggcuccccc uaauggccac gugucucccg uccaggccaa guacauucuu      960

aaagauuccu uuagcaucuu cugugagaca ggguaugaac ugcuccaggg acaucugccu     1020

cugaagucuu uuaccgcggu gugccaaaag gacggcagcu gggauagacc caugccggcc     1080

uguuccauug uggacugcgg gccucccgau gaccucccuu cuggacgggu cgaguacauc     1140

acgggccccg gcguuacaac cuacaaagcu gugauucagu auagcuguga ggaaaccuuc     1200

uacacaauga aggugaacga ugggaaauau gucugcgagg ccgacggauu uuggaccucc     1260

agcaagggcg aaaaaucucu gccugugugu gagcccguuu gcgggcuuuc cgcucgcaca     1320

acgggaggca gaaucuacgg gggccagaag gccaaaccgg gagauuuccc uuggcaagug     1380

cugauucucg gcgggaccac agccgcugga gcgcugcuuu augacaauug gguccugacc     1440

gccgcucacg ccguguacga acagaagcau gaugccagcg cucucgacau ccggaugggc     1500

acacugaaga gacugucucc ccacuauacc caggccuggu ccgaggcggu uuuuauccau     1560

gagggguaca cgcacgacgc uggauucgau aacgacauug cccucaucaa acugaauaac     1620

aaggugguca uuaauagcaa caucaccccc auuugucuuc cucgcaaaga agccgagucc     1680

uuuaugcgga cagaugacau cggcaccgcu ucuggguggg gccugacaca gagaggauuc     1740

cucgcccgca aucugaugua cguggauauc ccgauugucg accaccaaaa gugcaccgcu     1800

gccuaugaaa aacccccuua cccccggggc agcgugacgg cgaacaugcu gugugccggg     1860

cuugaguccg gaggcaagga uucuugcaga ggggacagcg gaggcgcucu cguuuuucug     1920

gauuccgaga cagaacgcug guucgucggg ggcaucguga gcuggggauc uaugaauugc     1980

ggcgaggccg ggcaguaugg aguguacacc aagguuauua acuauauccc uuggauugaa     2040

aacaucaucu ccgacuucug a                                               2061


<210>  8122
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MBL__Homo_sapiens__P11226

<400>  8122

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  8123
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8123
augucccugu uuccaucacu cccucuccuu cuccugagua ugguggcagc gucuuacuca       60

gaaacuguga ccugugagga ugcccaaaag accugcccug cagugauugc cuguagcucu      120

ccaggcauca acggcuuccc aggcaaagau gggcgugaug gcaccaaggg agaaaagggg      180

gaaccaggcc aagggcucag aggcuuacag ggccccccug gaaaguuggg gccuccagga      240

aauccagggc cuucuggguc accaggacca aagggccaaa aaggagaccc uggaaaaagu      300

ccggauggug auaguagccu ggcugccuca gaaagaaaag cucugcaaac agaaauggca      360

cguaucaaaa aguggcugac cuucucucug ggcaaacaag uugggaacaa guucuuccug      420

accaauggug aaauaaugac cuuugaaaaa gugaaggccu ugugugucaa guuccaggcc      480

ucuguggcca cccccaggaa ugcugcagag aauggagcca uucagaaucu caucaaggag      540

gaagccuucc ugggcaucac ugaugagaag acagaagggc aguuugugga ucugacagga      600

aauagacuga ccuacacaaa cuggaacgag ggugaaccca acaaugcugg uucugaugaa      660

gauuguguau ugcuacugaa aaauggccag uggaaugacg uccccugcuc caccucccau      720

cuggccgucu gugaguuccc uaucuga                                          747


<210>  8124
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8124
augagccugu uccccucccu cccgcugcug cuccugagca ugguggccgc cuccuacagc       60

gagaccguga ccugcgagga cgcgcagaag acgugccccg ccgugaucgc cugcuccagc      120

cccggcauca acggguuccc cggcaaggac gggcgcgacg gcaccaaggg ggagaagggc      180

gagccgggcc aggggcugcg gggccuccag gggccgcccg gcaagcuggg gccgcccggc      240

aaccccggcc ccuccgggag ccccggcccc aaggggcaga agggcgaccc cggcaagucc      300

cccgacgggg acagcucccu ggccgccagc gagcgcaagg cgcuccagac cgagauggcc      360

cggaucaaga aguggcugac cuucucccug ggcaagcagg ucgggaacaa guucuuccuc      420

acgaacggcg agaucaugac cuucgagaag gucaaggccc ugugcgugaa guuccaggcc      480

agcguggcga cgccccgcaa cgccgccgag aacggggcca uccagaaccu gaucaaggag      540

gaggccuucc ucggcaucac cgacgagaag accgagggcc aguucgucga ccugaccggg      600

aaccggcuga ccuacaccaa cuggaacgag ggcgagccga acaacgcggg guccgacgag      660

gacugcgugc uccugcugaa gaacggccag uggaacgacg ugcccugcag cacgucccac      720

cucgccgucu gcgaguuccc caucuga                                          747


<210>  8125
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8125
augucccucu uccccucccu cccccuccuc cuccucucca uggucgccgc cuccuacucc       60

gagaccguca ccugcgagga cgcccagaag accugccccg ccgucaucgc cugcuccucc      120

cccggcauca acggcuuccc cggcaaggac ggccgcgacg gcaccaaggg cgagaagggc      180

gagcccggcc agggccuccg cggccuccag ggcccccccg gcaagcucgg cccccccggc      240

aaccccggcc ccuccggcuc ccccggcccc aagggccaga agggcgaccc cggcaagucc      300

cccgacggcg acuccucccu cgccgccucc gagcgcaagg cccuccagac cgagauggcc      360

cgcaucaaga aguggcucac cuucucccuc ggcaagcagg ucggcaacaa guucuuccuc      420

accaacggcg agaucaugac cuucgagaag gucaaggccc ucugcgucaa guuccaggcc      480

uccgucgcca ccccccgcaa cgccgccgag aacggcgcca uccagaaccu caucaaggag      540

gaggccuucc ucggcaucac cgacgagaag accgagggcc aguucgucga ccucaccggc      600

aaccgccuca ccuacaccaa cuggaacgag ggcgagccca acaacgccgg cuccgacgag      660

gacugcgucc uccuccucaa gaacggccag uggaacgacg uccccugcuc caccucccac      720

cucgccgucu gcgaguuccc caucuga                                          747


<210>  8126
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8126
augagccugu uccccucccu cccucuucug uuguuaucua ugguggccgc uucauacagu       60

gagacuguca caugcgaaga cgcacagaag acuuguccag ccguuaucgc gugcagcucc      120

ccgggcauua acggguuucc cggaaaagau gguagagacg gcacgaaggg ggagaaagga      180

gaaccuggcc aaggucugag ggggcuacag ggaccacccg gcaagcucgg cccuccaggg      240

aaucccggac cuucugguuc gccaggcccg aaagggcaga agggagaucc cggcaaguca      300

ccugacggug auagcagucu ggcugccucc gagcggaaag cacuucagac cgaaauggcc      360

cgcauaaaga aauggcugac auucucuuug gggaagcaag ugggaaacaa auuuuuccuc      420

acuaauggcg agaucaugac cuuugagaag guaaaggcuc ugugugugaa auuccaggca      480

agcgucgcca caccacgaaa cgcugccgaa aauggcgcga uucagaaccu gaucaaggag      540

gaagcauuuc ucgggauuac cgacgagaaa acugagggac aguucgugga uuuaacaggu      600

aaucgucuga ccuauacgaa cuggaaugaa ggcgagccca acaaugccgg guccgacgaa      660

gauugcguuc uuuugcugaa gaacggacaa uggaaugacg ugccuuguuc aaccagucac      720

cuagcugucu gcgaguuucc aaucuga                                          747


<210>  8127
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8127
augagccugu uccccagccu gccccugcug cugcugagca ugguggccgc cagcuacagc       60

gagaccguga ccugcgagga cgcccagaag accugccccg ccgugaucgc cugcagcagc      120

cccggcauca acggcuuccc cggcaaggac ggcagagacg gcaccaaggg cgagaagggc      180

gagcccggcc agggccugag aggccugcag ggcccccccg gcaagcuggg cccccccggc      240

aaccccggcc ccagcggcag ccccggcccc aagggccaga agggcgaccc cggcaagagc      300

cccgacggcg acagcagccu ggccgccagc gagagaaagg cccugcagac cgagauggcc      360

agaaucaaga aguggcugac cuucagccug ggcaagcagg ugggcaacaa guucuuccug      420

accaacggcg agaucaugac cuucgagaag gugaaggccc ugugcgugaa guuccaggcc      480

agcguggcca cccccagaaa cgccgccgag aacggcgcca uccagaaccu gaucaaggag      540

gaggccuucc ugggcaucac cgacgagaag accgagggcc aguucgugga ccugaccggc      600

aacagacuga ccuacaccaa cuggaacgag ggcgagccca acaacgccgg cagcgacgag      660

gacugcgugc ugcugcugaa gaacggccag uggaacgacg ugcccugcag caccagccac      720

cuggccgugu gcgaguuccc caucuga                                          747


<210>  8128
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_MBL__Homo_sapiens__AAC31937

<400>  8128
augagccugu uccccucccu cccucugcuu cugcucucua ugguggccgc uagcuacucc       60

gagaccguca caugcgaaga cgcccagaag acguguccgg cgguuaucgc uugcucuagc      120

cccggcauua acggguuucc uggaaaagau ggcagagacg ggaccaaggg agagaaaggc      180

gaacccgggc aaggacugcg gggccuucag ggcccucccg ggaagcuggg accuccgggc      240

aaucccgggc cuuccggauc ucccggcccu aaagggcaga agggagaucc cggcaagagc      300

ccggacggcg auuccagccu cgccgccucu gagcgcaaag cucugcagac agaaauggcc      360

agaaucaaga aauggcugac cuucucccuc gggaagcaag ugggaaacaa auuuuuccug      420

acaaauggcg agauuaugac cuuugagaag gugaaggcuc uuugugucaa auuccaggcc      480

agcguggcga caccucggaa cgccgcugaa aauggggcca uccagaaccu gauuaaggag      540

gaagccuuuc ucggaaucac cgacgagaaa acggagggcc aguucguuga ucugaccggg      600

aaucgccuua cauauaccaa cuggaaugaa ggagagccca acaaugcugg cucugacgaa      660

gauugcgugc ugcuccugaa gaacggccaa uggaaugacg ucccuuguuc cacaagccac      720

cuggcggugu gcgaguuucc caucuga                                          747


<210>  8129
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MCP__Homo_sapiens__P15529

<400>  8129

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  8130
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8130
auggagccuc ccggccgccg cgaguguccc uuuccuuccu ggcgcuuucc uggguugcuu       60

cuggcggcca ugguguugcu gcuguacucc uucuccgaug ccugugagga gccaccaaca      120

uuugaagcua uggagcucau ugguaaacca aaacccuacu augagauugg ugaacgagua      180

gauuauaagu guaaaaaagg auacuucuau auaccuccuc uugccaccca uacuauuugu      240

gaucggaauc auacauggcu accugucuca gaugacgccu guuauagaga aacaugucca      300

uauauacggg auccuuuaaa uggccaagca gucccugcaa augggacuua cgaguuuggu      360

uaucagaugc acuuuauuug uaaugagggu uauuacuuaa uuggugaaga aauucuauau      420

ugugaacuua aaggaucagu agcaauuugg agcgguaagc ccccaauaug ugaaaagguu      480

uuguguacac caccuccaaa aauaaaaaau ggaaaacaca ccuuuaguga aguagaagua      540

uuugaguauc uugaugcagu aacuuauagu ugugauccug caccuggacc agauccauuu      600

ucacuuauug gagagagcac gauuuauugu ggugacaauu caguguggag ucgugcugcu      660

ccagagugua aaguggucaa augucgauuu ccaguagucg aaaauggaaa acagauauca      720

ggauuuggaa aaaaauuuua cuacaaagca acaguuaugu uugaaugcga uaaggguuuu      780

uaccucgaug gcagcgacac aauugucugu gacaguaaca guacuuggga ucccccaguu      840

ccaaaguguc uuaaagugcu gccuccaucu aguacaaaac cuccagcuuu gagucauuca      900

gugucgacuu cuuccacuac aaaaucucca gcguccagug ccucaggucc uaggccuacu      960

uacaagccuc cagucucaaa uuauccagga uauccuaaac cugaggaagg aauacuugac     1020

aguuuggaug uuugggucau ugcugugauu guuauugcca uaguuguugg aguugcagua     1080

auuuguguug ucccguacag auaucuucaa aggaggaaga agaaaggcac auaccuaacu     1140

gaugagaccc acagagaagu aaaauuuacu ucucucuga                            1179


<210>  8131
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8131
auggagcccc cgggccgccg ggagugcccc uuccccagcu ggcgcuuccc cgggcugcuc       60

cuggccgcca uggugcugcu ccuguacucc uucagcgacg cgugcgagga gccgcccacc      120

uucgaggcca uggagcugau cggcaagccc aagcccuacu acgagaucgg ggagcggguc      180

gacuacaagu gcaagaaggg cuacuucuac aucccgcccc ucgccaccca cacgaucugc      240

gaccgcaacc acaccuggcu gcccgugucc gacgacgccu gcuaccggga gaccugcccc      300

uacauccgcg acccgcugaa cgggcaggcc gugcccgcga acggcaccua cgaguucggc      360

uaccagaugc acuucaucug caacgagggg uacuaccuca ucggcgagga gauccuguac      420

ugcgagcuga aggggagcgu cgccaucugg uccggcaagc cgcccaucug cgagaaggug      480

cucugcacgc ccccgcccaa gaucaagaac gggaagcaca ccuucagcga gguggagguc      540

uucgaguacc uggacgccgu gaccuacucc ugcgaccccg cccccggccc cgaccccuuc      600

agccugaucg gcgaguccac caucuacugc ggggacaaca gcgugugguc ccgggcggcc      660

cccgagugca aggucgugaa gugccgcuuc ccgguggucg agaacggcaa gcagaucagc      720

ggguucggca agaaguucua cuacaaggcc acggugaugu ucgagugcga caagggcuuc      780

uaccucgacg gguccgacac caucgugugc gacagcaacu ccaccuggga cccgcccguc      840

cccaagugcc ugaaggugcu gccgcccagc uccaccaagc cgcccgcccu cagccacucc      900

gugagcacga gcuccaccac caagagcccc gccuccagcg cguccggccc ccggcccacc      960

uacaagccgc ccgucagcaa cuaccccggg uaccccaagc ccgaggaggg cauccuggac     1020

ucccuggacg ugugggugau cgccgucauc gugaucgcca ucguggucgg gguggccguc     1080

aucugcgugg ugcccuaccg cuaccuccag cggcgcaaga agaagggcac guaccugacc     1140

gacgagaccc accgggaggu caaguucacc agccuguga                            1179


<210>  8132
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8132
auggagcccc ccggccgccg cgagugcccc uuccccuccu ggcgcuuccc cggccuccuc       60

cucgccgcca ugguccuccu ccucuacucc uucuccgacg ccugcgagga gccccccacc      120

uucgaggcca uggagcucau cggcaagccc aagcccuacu acgagaucgg cgagcgcguc      180

gacuacaagu gcaagaaggg cuacuucuac aucccccccc ucgccaccca caccaucugc      240

gaccgcaacc acaccuggcu ccccgucucc gacgacgccu gcuaccgcga gaccugcccc      300

uacauccgcg acccccucaa cggccaggcc guccccgcca acggcaccua cgaguucggc      360

uaccagaugc acuucaucug caacgagggc uacuaccuca ucggcgagga gauccucuac      420

ugcgagcuca agggcuccgu cgccaucugg uccggcaagc cccccaucug cgagaagguc      480

cucugcaccc ccccccccaa gaucaagaac ggcaagcaca ccuucuccga ggucgagguc      540

uucgaguacc ucgacgccgu caccuacucc ugcgaccccg cccccggccc cgaccccuuc      600

ucccucaucg gcgaguccac caucuacugc ggcgacaacu ccgucugguc ccgcgccgcc      660

cccgagugca aggucgucaa gugccgcuuc cccgucgucg agaacggcaa gcagaucucc      720

ggcuucggca agaaguucua cuacaaggcc accgucaugu ucgagugcga caagggcuuc      780

uaccucgacg gcuccgacac caucgucugc gacuccaacu ccaccuggga cccccccguc      840

cccaagugcc ucaagguccu cccccccucc uccaccaagc cccccgcccu cucccacucc      900

gucuccaccu ccuccaccac caaguccccc gccuccuccg ccuccggccc ccgccccacc      960

uacaagcccc ccgucuccaa cuaccccggc uaccccaagc ccgaggaggg cauccucgac     1020

ucccucgacg ucugggucau cgccgucauc gucaucgcca ucgucgucgg cgucgccguc     1080

aucugcgucg uccccuaccg cuaccuccag cgccgcaaga agaagggcac cuaccucacc     1140

gacgagaccc accgcgaggu caaguucacc ucccucuga                            1179


<210>  8133
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8133
auggagcccc cuggcagaag ggaaugccca uucccgagcu ggcgguuucc cgggcugcuc       60

cuugccgcua uggugcuguu guuauacucc uucucugacg caugugagga accuccaacc      120

uuugaggcca uggaacugau cggaaagccc aaaccuuauu acgagauugg ugagcgcguc      180

gauuauaagu gcaaaaaggg cuacuucuau auaccacccc uagcgacaca cacuaucugu      240

gaccgaaacc auacguggcu cccuguuuca gaugacgcuu gcuaccguga aaccugucca      300

uauauuagag auccgcugaa ugggcaggcc gugcccgcaa acggaacaua cgaguuuggc      360

uaccaaaugc acuucaucug caaugaaggu uauuaccuua uuggggagga gauccuguau      420

ugugaauuga aaggaagugu agccauaugg agcggcaagc cuccaaucug cgagaaggug      480

cucuguacuc ccccuccaaa aauuaagaac ggcaaacaua ccuuuuccga agucgaggug      540

uucgaauacc uggacgcugu uacauauucu ugcgaucccg caccggggcc ugaccccuuu      600

ucgcugaucg gagagucaac cauuuacugu ggugauaaua gcguguggag uagggccgcu      660

ccagagugca aggucgugaa augccgguuc ccuguaguug aaaacggcaa gcagaucucc      720

ggguuuggaa agaaauucua uuacaaggcc acugugaugu uugaguguga caaaggcuuc      780

uaccucgaug guucugacac aauagucugc gauagcaauu ccaccuggga ucccccagug      840

cccaaguguu uaaaagugcu gccuccauca aguacgaagc cgcccgcgcu uagccacucu      900

gucuccacuu caagcaccac aaaaaguccu gcaucuuccg ccagcgggcc acgccccacu      960

uauaagccuc caguuucgaa cuaccccgga uauccgaagc cugaagaggg cauuuuggac     1020

ucucuggacg uguggguaau cgcugugauu gucaucgcca ucgugguugg cguggcaguc     1080

auuugcgugg uaccauacag auaucuacag aggcggaaaa agaaagggac cuaccucaca     1140

gacgaaaccc aucgcgaggu uaaguucacg ucccuguga                            1179


<210>  8134
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8134
auggagcccc ccggcagaag agagugcccc uuccccagcu ggagauuccc cggccugcug       60

cuggccgcca uggugcugcu gcuguacagc uucagcgacg ccugcgagga gccccccacc      120

uucgaggcca uggagcugau cggcaagccc aagcccuacu acgagaucgg cgagagagug      180

gacuacaagu gcaagaaggg cuacuucuac aucccccccc uggccaccca caccaucugc      240

gacagaaacc acaccuggcu gcccgugagc gacgacgccu gcuacagaga gaccugcccc      300

uacaucagag acccccugaa cggccaggcc gugcccgcca acggcaccua cgaguucggc      360

uaccagaugc acuucaucug caacgagggc uacuaccuga ucggcgagga gauccuguac      420

ugcgagcuga agggcagcgu ggccaucugg agcggcaagc cccccaucug cgagaaggug      480

cugugcaccc ccccccccaa gaucaagaac ggcaagcaca ccuucagcga gguggaggug      540

uucgaguacc uggacgccgu gaccuacagc ugcgaccccg cccccggccc cgaccccuuc      600

agccugaucg gcgagagcac caucuacugc ggcgacaaca gcguguggag cagagccgcc      660

cccgagugca agguggugaa gugcagauuc cccguggugg agaacggcaa gcagaucagc      720

ggcuucggca agaaguucua cuacaaggcc accgugaugu ucgagugcga caagggcuuc      780

uaccuggacg gcagcgacac caucgugugc gacagcaaca gcaccuggga cccccccgug      840

cccaagugcc ugaaggugcu gccccccagc agcaccaagc cccccgcccu gagccacagc      900

gugagcacca gcagcaccac caagagcccc gccagcagcg ccagcggccc cagacccacc      960

uacaagcccc ccgugagcaa cuaccccggc uaccccaagc ccgaggaggg cauccuggac     1020

agccuggacg ugugggugau cgccgugauc gugaucgcca ucgugguggg cguggccgug     1080

aucugcgugg ugcccuacag auaccugcag agaagaaaga agaagggcac cuaccugacc     1140

gacgagaccc acagagaggu gaaguucacc agccuguga                            1179


<210>  8135
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_MCP__Homo_sapiens__AAW82433

<400>  8135
auggagcccc cuggcagacg ggaaugcccg uuccccagcu ggcgcuuucc ugggcugcuc       60

cuggccgcua uggugcuucu gcucuacucc uucucugacg ccugugagga acccccuacc      120

uuugaggcga uggaacugau cggaaagccc aaaccuuauu acgagauugg cgagagaguc      180

gauuauaagu gcaaaaaggg guacuucuau aucccgcccc uugcuacaca cacgauuugu      240

gaccggaacc auaccuggcu gccuguuagc gaugacgccu gcuaccgcga aacauguccc      300

uauaucagag auccucucaa uggacaggcc gugcccgcua acggcaccua cgaguuuggg      360

uaccaaaugc acuucauuug caaugaagga uauuaccuga ucggcgagga gauccuguau      420

ugugaacuca aaggcuccgu ggccauuugg ucugggaagc cgccuaucug cgagaagguc      480

cuguguacac ccccucccaa aauuaagaac ggaaaacaua ccuuuagcga aguggagguu      540

uucgaauacc uugacgcugu gacauauucc ugcgaucccg ccccuggccc ggaccccuuu      600

ucucugaucg gggagagcac cauuuacugu ggagauaauu ccgucuggag ccgggcggcc      660

ccugagugca aggugguuaa augccgcuuc cccguggucg aaaacggcaa gcagaucucu      720

ggguuuggaa agaaauucua uuacaaggcu acggugaugu uugaguguga caaaggcuuc      780

uaccucgaug gcuccgacac cauugugugc gauagcaauu cuacauggga cccucccguc      840

ccgaaguguc ugaaaguucu uccucccucc agcaccaagc cucccgcccu gucucacucc      900

gugagcacau ccucuaccac gaaaagcccu gcuuccagcg ccucugggcc cagaccgaca      960

uauaagccuc ccguguccaa cuaccccgga uauccuaagc cggaagaggg cauccucgac     1020

agccuggaug ucugggugau cgcgguuauu gugaucgcca uugucguggg gguugcugug     1080

aucugcgucg ugcccuaccg guaucugcag cgccggaaaa agaaaggaac cuaccucaca     1140

gacgaaaccc auagagaggu caaguucacc ucucuguga                            1179


<210>  8136
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MCP__Homo_sapiens__P40121

<400>  8136

Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val 
1               5                   10                  15      


Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val 
            20                  25                  30          


Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr 
        35                  40                  45              


Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp 
    50                  55                  60                  


Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu 
65                  70                  75                  80  


Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg 
            100                 105                 110         


Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr 
        115                 120                 125             


Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly 
    130                 135                 140                 


Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe 
145                 150                 155                 160 


Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala 
                165                 170                 175     


Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp 
            180                 185                 190         


Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val 
        195                 200                 205             


Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr 
225                 230                 235                 240 


Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp 
                245                 250                 255     


Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe 
            260                 265                 270         


Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly 
        275                 280                 285             


Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys 
    290                 295                 300                 


Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met 
305                 310                 315                 320 


Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly His Glu 
                325                 330                 335     


Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys 
            340                 345             


<210>  8137
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8137
auguacacag ccauucccca gaguggcucu ccauucccag gcucagugca ggauccaggc       60

cugcaugugu ggcgggugga gaagcugaag ccggugccug uggcgcaaga gaaccagggc      120

gucuucuucu cgggggacuc cuaccuagug cugcacaaug gcccagaaga gguuucccau      180

cugcaccugu ggauaggcca gcagucaucc cgggaugagc agggggccug ugccgugcug      240

gcugugcacc ucaacacgcu gcugggagag cggccugugc agcaccgcga ggugcagggc      300

aaugagucug accucuucau gagcuacuuc ccacggggcc ucaaguacca ggaagguggu      360

guggagucag cauuucacaa gaccuccaca ggagccccag cugccaucaa gaaacucuac      420

caggugaagg ggaagaagaa cauccgugcc accgagcggg cacugaacug ggacagcuuc      480

aacacugggg acugcuucau ccuggaccug ggccagaaca ucuucgccug guguggugga      540

aaguccaaca uccuggaacg caacaaggcg agggaccugg cccuggccau ccgggacagu      600

gagcgacagg gcaaggccca gguggagauu gucacugaug gggaggagcc ugcugagaug      660

auccaggucc ugggccccaa gccugcucug aaggagggca acccugagga agaccucaca      720

gcugacaagg caaaugccca ggccgcagcu cuguauaagg ucucugaugc cacuggacag      780

augaaccuga ccaagguggc ugacuccagc ccauuugccc uugaacugcu gauaucugau      840

gacugcuuug ugcuggacaa cgggcucugu ggcaagaucu auaucuggaa ggggcgaaaa      900

gcgaaugaga aggagcggca ggcagcccug cagguggccg agggcuucau cucgcgcaug      960

caguacgccc cgaacacuca gguggagauu cugccucagg gccaugagag ucccaucuuc     1020

aagcaauuuu ucaaggacug gaaauga                                         1047


<210>  8138
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8138
auguacacgg ccauccccca gagcggcucc ccguuccccg ggagcgugca ggaccccggc       60

cugcacgucu ggcgcgugga gaagcugaag cccgugccgg ucgcccagga gaaccagggg      120

guguucuucu ccggcgacag cuaccuggug cugcacaacg ggcccgagga ggucucccac      180

cuccaccugu ggaucggcca gcagagcucc cgggacgagc agggcgcgug cgccgugcug      240

gccgugcacc ucaacacccu gcugggggag cgccccgucc agcaccggga ggugcagggc      300

aacgagagcg accucuucau guccuacuuc ccccgcgggc ugaaguacca ggagggcggg      360

guggagagcg ccuuccacaa gacguccacc ggcgccccgg cggccaucaa gaagcuguac      420

caggucaagg gcaagaagaa cauccgggcc accgagcgcg cccucaacug ggacagcuuc      480

aacaccgggg acugcuucau ccuggaccug ggccagaaca ucuucgcgug gugcgggggc      540

aaguccaaca uccucgagcg gaacaaggcc cgcgaccugg cccuggccau ccgggacagc      600

gagcgccagg gcaaggccca gguggagauc gugacggacg gggaggagcc cgcggagaug      660

auccaggucc ucggccccaa gcccgcccug aaggagggga acccggagga ggaccugacc      720

gccgacaagg ccaacgccca ggcggccgcc cucuacaagg uguccgacgc caccggccag      780

augaaccuga ccaagguggc cgacagcucc cccuucgcgc uggagcuccu gaucagcgac      840

gacugcuucg uccuggacaa cgggcucugc ggcaagaucu acaucuggaa gggccggaag      900

gccaacgaga aggagcgcca ggccgcccuc cagguggccg agggguucau cucccggaug      960

caguacgcgc ccaacaccca gguggagauc cugccccagg gccacgagag cccgaucuuc     1020

aagcaguucu ucaaggacug gaaguga                                         1047


<210>  8139
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8139
auguacaccg ccauccccca guccggcucc cccuuccccg gcuccgucca ggaccccggc       60

cuccacgucu ggcgcgucga gaagcucaag cccguccccg ucgcccagga gaaccagggc      120

gucuucuucu ccggcgacuc cuaccucguc cuccacaacg gccccgagga ggucucccac      180

cuccaccucu ggaucggcca gcaguccucc cgcgacgagc agggcgccug cgccguccuc      240

gccguccacc ucaacacccu ccucggcgag cgccccgucc agcaccgcga gguccagggc      300

aacgaguccg accucuucau guccuacuuc ccccgcggcc ucaaguacca ggagggcggc      360

gucgaguccg ccuuccacaa gaccuccacc ggcgcccccg ccgccaucaa gaagcucuac      420

caggucaagg gcaagaagaa cauccgcgcc accgagcgcg cccucaacug ggacuccuuc      480

aacaccggcg acugcuucau ccucgaccuc ggccagaaca ucuucgccug gugcggcggc      540

aaguccaaca uccucgagcg caacaaggcc cgcgaccucg cccucgccau ccgcgacucc      600

gagcgccagg gcaaggccca ggucgagauc gucaccgacg gcgaggagcc cgccgagaug      660

auccaggucc ucggccccaa gcccgcccuc aaggagggca accccgagga ggaccucacc      720

gccgacaagg ccaacgccca ggccgccgcc cucuacaagg ucuccgacgc caccggccag      780

augaaccuca ccaaggucgc cgacuccucc cccuucgccc ucgagcuccu caucuccgac      840

gacugcuucg uccucgacaa cggccucugc ggcaagaucu acaucuggaa gggccgcaag      900

gccaacgaga aggagcgcca ggccgcccuc caggucgccg agggcuucau cucccgcaug      960

caguacgccc ccaacaccca ggucgagauc cucccccagg gccacgaguc ccccaucuuc     1020

aagcaguucu ucaaggacug gaaguga                                         1047


<210>  8140
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8140
auguacaccg ccauccccca gagcggcucc ccuuucccag ggucugugca agacccggga       60

cugcacgucu ggagaguuga gaagcucaaa cccgugccug uagcucagga aaaccagggu      120

guguuuuucu caggcgauag uuaucuuguc cugcauaaug ggccagagga agugagccac      180

uugcauuuau ggauuggaca gcaauccucu agggacgagc agggcgcaug cgccguucug      240

gcggugcacc uaaacacacu ccugggugaa cggcccgucc agcaucgcga ggugcagggg      300

aaugagucgg aucuuuuuau gucauacuuc ccucgaggac ugaaguauca agaaggcggc      360

guagagagcg cuuuucacaa aacgaguacu ggggccccag cagccauaaa gaaauuguac      420

cagguuaagg gaaagaaaaa cauccgugcu accgaaagag cacucaauug ggacuccuuc      480

aacacaggug auuguuuuau ucuggaccug ggccagaaua ucuucgccug gugcggggga      540

aagucuaaca uucucgagag gaauaaagcu cgggauuuag cccuggcgau ccgcgacagc      600

gagagacagg gcaaggcaca aguggaaaua gucacugaug gugaggaacc cgccgagaug      660

auccaggugc uugggccuaa accagcuuug aaggaaggaa acccggagga ggaccugacc      720

gccgauaagg caaaugcuca ggccgcggcc cuauauaaag uguccgacgc aacaggccaa      780

augaaccuca ccaaggucgc ugauucaagu cccuuugccc uggaacuucu gauuagcgac      840

gacuguuucg uuuuggauaa uggccucugc gggaaaaucu acauuuggaa gggaaggaaa      900

gcuaacgaga aggaacggca ggccgcauua cagguggccg aggguuuuau cucucgcaug      960

caguaugcuc cuaauacuca aguagaaaua cugccacagg gccacgaguc ccccauuuuc     1020

aaacaguuuu ucaaggacug gaaguga                                         1047


<210>  8141
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8141
auguacaccg ccauccccca gagcggcagc cccuuccccg gcagcgugca ggaccccggc       60

cugcacgugu ggagagugga gaagcugaag cccgugcccg uggcccagga gaaccagggc      120

guguucuuca gcggcgacag cuaccuggug cugcacaacg gccccgagga ggugagccac      180

cugcaccugu ggaucggcca gcagagcagc agagacgagc agggcgccug cgccgugcug      240

gccgugcacc ugaacacccu gcugggcgag agacccgugc agcacagaga ggugcagggc      300

aacgagagcg accuguucau gagcuacuuc cccagaggcc ugaaguacca ggagggcggc      360

guggagagcg ccuuccacaa gaccagcacc ggcgcccccg ccgccaucaa gaagcuguac      420

caggugaagg gcaagaagaa caucagagcc accgagagag cccugaacug ggacagcuuc      480

aacaccggcg acugcuucau ccuggaccug ggccagaaca ucuucgccug gugcggcggc      540

aagagcaaca uccuggagag aaacaaggcc agagaccugg cccuggccau cagagacagc      600

gagagacagg gcaaggccca gguggagauc gugaccgacg gcgaggagcc cgccgagaug      660

auccaggugc ugggccccaa gcccgcccug aaggagggca accccgagga ggaccugacc      720

gccgacaagg ccaacgccca ggccgccgcc cuguacaagg ugagcgacgc caccggccag      780

augaaccuga ccaagguggc cgacagcagc cccuucgccc uggagcugcu gaucagcgac      840

gacugcuucg ugcuggacaa cggccugugc ggcaagaucu acaucuggaa gggcagaaag      900

gccaacgaga aggagagaca ggccgcccug cagguggccg agggcuucau cagcagaaug      960

caguacgccc ccaacaccca gguggagauc cugccccagg gccacgagag ccccaucuuc     1020

aagcaguucu ucaaggacug gaaguga                                         1047


<210>  8142
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       complement_system_component_MCP__Homo_sapiens__AAY24128

<400>  8142
auguacaccg ccauccccca gagcggcucc ccuuucccgg ggucugugca agaccccgga       60

cugcacgucu ggagaguuga gaagcucaaa ccugugcccg uggcucagga aaaccagggc      120

gucuuuuuca gcggggauuc cuaucuggug cuucauaaug gaccugagga aguuucucau      180

cugcaccucu ggauuggcca gcaaagcucc cgggacgagc agggggccug cgcggugcug      240

gcuguccacc uuaacacacu gcucggagaa cgccccgugc agcauagaga gguucagggc      300

aaugagucug aucuguuuau gagcuacuuc ccucggggcc ugaaguauca agaaggggga      360

guggaguccg ccuuucacaa aacgagcacc ggcgccccgg cugccaucaa gaaacucuac      420

caggucaagg ggaagaaaaa cauucgcgcu acagaaagag cccugaauug ggacucuuuc      480

aacaccggag auuguuuuau ccuugaccug ggccagaaua uuuucgcgug gugcggggga      540

aaguccaaca uccucgagcg gaauaaagcc cgcgaucugg cucuugccau cagagacagc      600

gagcggcagg gcaaggcuca aguggaaauu gugacagaug gcgaggaacc cgccgagaug      660

auccaggucc uggggccuaa acccgcgcuc aaggaaggaa acccugagga ggaccugacc      720

gccgauaagg cuaaugccca ggcugccgcc cuguauaaag uuucugacgc uacaggccaa      780

augaaccuca ccaagguggc ggauuccagc cccuuugccc uggaacuucu gauuucugac      840

gacuguuucg ugcucgauaa ugggcugugc ggaaaaaucu acauuuggaa gggccgcaaa      900

gcuaacgaga aggaaagaca ggccgcccuu caggucgcug agggguuuau cucccggaug      960

caguaugccc cgaauacgca aguggaaauu cugccucagg gacacgagag ccccaucuuc     1020

aaacaguuuu ucaaggacug gaaguga                                         1047


<210>  8143
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CREB3__Homo_sapiens__CCDS6588.1

<400>  8143

Met Glu Leu Glu Leu Asp Ala Gly Asp Gln Asp Leu Leu Ala Phe Leu 
1               5                   10                  15      


Leu Glu Glu Ser Gly Asp Leu Gly Thr Ala Pro Asp Glu Ala Val Arg 
            20                  25                  30          


Ala Pro Leu Asp Trp Ala Leu Pro Leu Ser Glu Val Pro Ser Asp Trp 
        35                  40                  45              


Glu Val Asp Asp Leu Leu Cys Ser Leu Leu Ser Pro Pro Ala Ser Leu 
    50                  55                  60                  


Asn Ile Leu Ser Ser Ser Asn Pro Cys Leu Val His His Asp His Thr 
65                  70                  75                  80  


Tyr Ser Leu Pro Arg Glu Thr Val Ser Met Asp Leu Glu Ser Glu Ser 
                85                  90                  95      


Cys Arg Lys Glu Gly Thr Gln Met Thr Pro Gln His Met Glu Glu Leu 
            100                 105                 110         


Ala Glu Gln Glu Ile Ala Arg Leu Val Leu Thr Asp Glu Glu Lys Ser 
        115                 120                 125             


Leu Leu Glu Lys Glu Gly Leu Ile Leu Pro Glu Thr Leu Pro Leu Thr 
    130                 135                 140                 


Lys Thr Glu Glu Gln Ile Leu Lys Arg Val Arg Arg Lys Ile Arg Asn 
145                 150                 155                 160 


Lys Arg Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Val Tyr Val Gly 
                165                 170                 175     


Gly Leu Glu Ser Arg Val Leu Lys Tyr Thr Ala Gln Asn Met Glu Leu 
            180                 185                 190         


Gln Asn Lys Val Gln Leu Leu Glu Glu Gln Asn Leu Ser Leu Leu Asp 
        195                 200                 205             


Gln Leu Arg Lys Leu Gln Ala Met Val Ile Glu Ile Ser Asn Lys Thr 
    210                 215                 220                 


Ser Ser Ser Ser Thr Cys Ile Leu Val Leu Leu Val Ser Phe Cys Leu 
225                 230                 235                 240 


Leu Leu Val Pro Ala Met Tyr Ser Ser Asp Thr Arg Gly Ser Leu Pro 
                245                 250                 255     


Ala Glu His Gly Val Leu Ser Arg Gln Leu Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Asp Pro Tyr Gln Leu Glu Leu Pro Ala Leu Gln Ser Glu Val Pro Lys 
        275                 280                 285             


Asp Ser Thr His Gln Trp Leu Asp Gly Ser Asp Cys Val Leu Gln Ala 
    290                 295                 300                 


Pro Gly Asn Thr Ser Cys Leu Leu His Tyr Met Pro Gln Ala Pro Ser 
305                 310                 315                 320 


Ala Glu Pro Pro Leu Glu Trp Pro Phe Pro Asp Leu Phe Ser Glu Pro 
                325                 330                 335     


Leu Cys Arg Gly Pro Ile Leu Pro Leu Gln Ala Asn Leu Thr Arg Lys 
            340                 345                 350         


Gly Gly Trp Leu Pro Thr Gly Ser Pro Ser Val Ile Leu Gln Asp Arg 
        355                 360                 365             


Tyr Ser Gly 
    370     


<210>  8144
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CREB3__Homo_sapiens__CCDS6588.1

<400>  8144
auggagcugg aauuggaugc uggugaccaa gaccugcugg ccuuccugcu agaggaaagu       60

ggagauuugg ggacggcacc cgaugaggcc gugagggccc cacuggacug ggcgcugccg      120

cuuucugagg uaccgagcga cugggaagua gaugauuugc ugugcucccu gcugaguccc      180

ccagcgucgu ugaacauucu cagcuccucc aaccccugcc uuguccacca ugaccacacc      240

uacucccucc cacgggaaac ugucucuaug gaucuagaga gugagagcug uagaaaagag      300

gggacccaga ugacuccaca gcauauggag gagcuggcag agcaggagau ugcuaggcua      360

guacugacag augaggagaa gagucuauug gagaaggagg ggcuuauucu gccugagaca      420

cuuccucuca cuaagacaga ggaacaaauu cugaaacgug ugcggaggaa gauucgaaau      480

aaaagaucug cucaagagag ccgcaggaaa aagaaggugu auguuggggg uuuagagagc      540

agggucuuga aauacacagc ccagaauaug gagcuucaga acaaaguaca gcuucuggag      600

gaacagaauu ugucccuucu agaucaacug aggaaacucc aggccauggu gauugagaua      660

ucaaacaaaa ccagcagcag cagcaccugc aucuuggucc uacuagucuc cuucugccuc      720

cuccuuguac cugcuaugua cuccucugac acaaggggga gccugccagc ugagcaugga      780

guguuguccc gccagcuucg ugcccucccc agugaggacc cuuaccagcu ggagcugccu      840

gcccugcagu cagaagugcc gaaagacagc acacaccagu gguuggacgg cucagacugu      900

guacuccagg ccccuggcaa cacuuccugc cugcugcauu acaugccuca ggcucccagu      960

gcagagccuc cccuggagug gccauucccu gaccucuucu cagagccucu cugccgaggu     1020

cccauccucc cccugcaggc aaaucucaca aggaagggag gauggcuucc uacugguagc     1080

cccucuguca uuuugcagga cagauacuca ggcuag                               1116


<210>  8145
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CREB3__Homo_sapiens__CCDS6588.1

<400>  8145
auggagcugg agcucgacgc cggcgaccag gaccugcugg ccuuccuccu ggaggagagc       60

ggggaccugg gcaccgcgcc cgacgaggcc gugcgcgccc cgcucgacug ggcccugccc      120

cuguccgagg uccccagcga cugggaggug gacgaccucc ugugcucccu gcucagcccg      180

cccgccuccc ugaacauccu gagcuccagc aaccccugcc ucgugcacca cgaccacacc      240

uacucccugc cccgggagac ggucagcaug gaccuggagu ccgagagcug ccgcaaggag      300

gggacccaga ugacgcccca gcacauggag gagcucgcgg agcaggagau cgcccggcug      360

gugcugaccg acgaggagaa gucccuccug gagaaggagg gccugauccu cccggagacc      420

cugccccuga ccaagaccga ggagcagauc cucaagcgcg ugcggcgcaa gauccggaac      480

aagcgcagcg cccaggaguc ccggcgcaag aagaaggucu acgucggggg ccuggagagc      540

cgggugcuga aguacaccgc ccagaacaug gagcuccaga acaaggugca gcugcuggag      600

gagcagaacc ucucccugcu ggaccagcuc cgcaagcugc aggcgauggu gaucgagauc      660

agcaacaaga cguccagcag cuccacgugc auccuggugc uccuggucag cuucugccug      720

cuccuggugc ccgccaugua cuccagcgac acccggggcu cccugcccgc cgagcacggg      780

gugcucagcc gccagcugcg ggcccugccg uccgaggacc ccuaccagcu cgagcugccc      840

gcccugcaga gcgagguccc caaggacucc acccaccagu ggcuggacgg cagcgacugc      900

gugcuccagg cgccggggaa caccuccugc cugcugcacu acaugcccca ggcccccagc      960

gccgagcccc cgcucgagug gcccuucccc gaccuguucu ccgagccccu gugccgcggc     1020

ccgauccucc cccugcaggc caaccugacc cggaagggcg gguggcuccc caccggcagc     1080

cccuccguga uccugcagga ccgcuacagc ggguga                               1116


<210>  8146
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CREB3__Homo_sapiens__CCDS6588.1

<400>  8146
auggagcucg agcucgacgc cggcgaccag gaccuccucg ccuuccuccu cgaggagucc       60

ggcgaccucg gcaccgcccc cgacgaggcc guccgcgccc cccucgacug ggcccucccc      120

cucuccgagg uccccuccga cugggagguc gacgaccucc ucugcucccu ccucuccccc      180

cccgccuccc ucaacauccu cuccuccucc aaccccugcc ucguccacca cgaccacacc      240

uacucccucc cccgcgagac cgucuccaug gaccucgagu ccgaguccug ccgcaaggag      300

ggcacccaga ugacccccca gcacauggag gagcucgccg agcaggagau cgcccgccuc      360

guccucaccg acgaggagaa gucccuccuc gagaaggagg gccucauccu ccccgagacc      420

cucccccuca ccaagaccga ggagcagauc cucaagcgcg uccgccgcaa gauccgcaac      480

aagcgcuccg cccaggaguc ccgccgcaag aagaaggucu acgucggcgg ccucgagucc      540

cgcguccuca aguacaccgc ccagaacaug gagcuccaga acaaggucca gcuccucgag      600

gagcagaacc ucucccuccu cgaccagcuc cgcaagcucc aggccauggu caucgagauc      660

uccaacaaga ccuccuccuc cuccaccugc auccucgucc uccucgucuc cuucugccuc      720

cuccucgucc ccgccaugua cuccuccgac acccgcggcu cccuccccgc cgagcacggc      780

guccucuccc gccagcuccg cgcccucccc uccgaggacc ccuaccagcu cgagcucccc      840

gcccuccagu ccgagguccc caaggacucc acccaccagu ggcucgacgg cuccgacugc      900

guccuccagg cccccggcaa caccuccugc cuccuccacu acaugcccca ggcccccucc      960

gccgagcccc cccucgagug gcccuucccc gaccucuucu ccgagccccu cugccgcggc     1020

cccauccucc cccuccaggc caaccucacc cgcaagggcg gcuggcuccc caccggcucc     1080

cccuccguca uccuccagga ccgcuacucc ggcuga                               1116


<210>  8147
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CREB3__Homo_sapiens__CCDS6588.1

<400>  8147
auggagcugg aacucgacgc cggcgaucag gaccuucugg cuuucuuguu agaggaaagc       60

ggggaucugg gaaccgcacc cgacgaggcc gugagagcgc cucuagauug ggcucuccca      120

cuguccgaag ucccgucuga cugggagguu gaugaccuuc ugugcucauu gcucaguccc      180

ccugccagcc ugaacauccu guccucuucg aauccauguc ucgugcacca ugaucacaca      240

uacucauuac ccagggagac uguaagcaug gaccuggaaa gugaguccug ccggaaggaa      300

gguacgcaaa ugaccccuca gcauauggag gagcuugcag aacaggagau ugcccgcuug      360

gugcugacag augaagagaa aucucuacuc gaaaaggagg gccugauacu uccagagacu      420

cugcccuuga ccaaaacaga ggaacagauc cucaagcgag uccguagaaa aauuaggaac      480

aagcggagcg cucaagaauc ccgcagaaag aaaaaggugu auguuggggg acuggaguca      540

aggguguuaa aauacaccgc acagaauaug gaacugcaga acaaggucca gcuccuugag      600

gagcaaaauc ugaguuugcu agaccagcug cggaaacucc aggccauggu gaucgaaauu      660

agcaacaaga cuucuuccuc aagcacaugu auccugguac uucugguuag uuuuugcuug      720

cuccuggugc cugcuaugua uucuuccgau acccgcggca gcuuaccagc cgagcacggu      780

guccugucgc gacagcuaag agcgcucccg ucugaagacc ccuaccaacu ggagcuuccu      840

gcauugcagu ccgaagugcc aaaggacuca acgcaucagu ggcuggaugg gagugacugu      900

gugcuccaag cccccggaaa uacuagcugc cugcuucacu auaugccuca ggcuccaucc      960

gccgagcccc cgcuggagug gccuuucccc gauuuguuuu cugaaccacu cuguaggggc     1020

ccuauacugc ccuuacaggc aaaccugacc cggaaaggcg gguggcuacc aacaggaagc     1080

cccucaguca uccuccagga ccguuacagu gguuga                               1116


<210>  8148
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CREB3__Homo_sapiens__CCDS6588.1

<400>  8148
auggagcugg agcuggacgc cggcgaccag gaccugcugg ccuuccugcu ggaggagagc       60

ggcgaccugg gcaccgcccc cgacgaggcc gugagagccc cccuggacug ggcccugccc      120

cugagcgagg ugcccagcga cugggaggug gacgaccugc ugugcagccu gcugagcccc      180

cccgccagcc ugaacauccu gagcagcagc aaccccugcc uggugcacca cgaccacacc      240

uacagccugc ccagagagac cgugagcaug gaccuggaga gcgagagcug cagaaaggag      300

ggcacccaga ugacccccca gcacauggag gagcuggccg agcaggagau cgccagacug      360

gugcugaccg acgaggagaa gagccugcug gagaaggagg gccugauccu gcccgagacc      420

cugccccuga ccaagaccga ggagcagauc cugaagagag ugagaagaaa gaucagaaac      480

aagagaagcg cccaggagag cagaagaaag aagaaggugu acgugggcgg ccuggagagc      540

agagugcuga aguacaccgc ccagaacaug gagcugcaga acaaggugca gcugcuggag      600

gagcagaacc ugagccugcu ggaccagcug agaaagcugc aggccauggu gaucgagauc      660

agcaacaaga ccagcagcag cagcaccugc auccuggugc ugcuggugag cuucugccug      720

cugcuggugc ccgccaugua cagcagcgac accagaggca gccugcccgc cgagcacggc      780

gugcugagca gacagcugag agcccugccc agcgaggacc ccuaccagcu ggagcugccc      840

gcccugcaga gcgaggugcc caaggacagc acccaccagu ggcuggacgg cagcgacugc      900

gugcugcagg cccccggcaa caccagcugc cugcugcacu acaugcccca ggcccccagc      960

gccgagcccc cccuggagug gcccuucccc gaccuguuca gcgagccccu gugcagaggc     1020

cccauccugc cccugcaggc caaccugacc agaaagggcg gcuggcugcc caccggcagc     1080

cccagcguga uccugcagga cagauacagc ggcuga                               1116


<210>  8149
<211>  1116
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CREB3__Homo_sapiens__CCDS6588.1

<400>  8149
auggagcugg aacucgacgc cggcgaucag gaccugcuug cuuuccugcu cgaggaaagc       60

ggggaucugg gaaccgcccc cgacgaggcg gugagagcuc cucuugauug ggcccugccg      120

cucuccgaag uccccucuga cugggagguu gaugaccugc ugugcagccu ccuguccccu      180

cccgccucuc uuaacauccu gagcuccucu aauccuuguc ucgugcacca ugaucacaca      240

uacagccugc cccgggagac gguguccaug gaccuugaaa gcgagucuug ccgcaaggaa      300

ggcacccaaa ugacaccuca gcauauggag gagcuggcug aacaggagau ugccagacuc      360

guccugaccg augaagagaa aucccugcuc gaaaaggagg ggcugauccu uccggagaca      420

cugccccuca ccaaaacaga ggaacagauu cugaagcggg ugcgcagaaa aauccggaac      480

aagcgcagcg cucaagaauc uagacggaag aaaaagguuu augugggagg ccuugagucc      540

cgcguccuga aauacaccgc ccagaauaug gaacuccaga acaaggugca gcugcuggag      600

gagcaaaauc ucagccugcu ugaccagcug agaaaacucc aggcgauggu uauugaaauc      660

ucuaacaaga cguccagcuc cucuaccugu auccuggugc uucuggucag cuuuugccuc      720

cugcuggugc cugccaugua uuccagcgau acacgggggu cucuccccgc ugagcacgga      780

gugcuguccc gccagcuuag agcccugccu agcgaagacc ccuaccaacu cgagcugccg      840

gcucugcagu cugaaguccc uaaggacagc acccaucagu ggcuugaugg cuccgacugu      900

guucuccaag cccccggcaa uacaucuugc cugcugcacu auaugccuca ggcgcccagc      960

gccgagcccc cucucgagug gccguucccc gaucuguuuu ccgaaccucu uugucggggg     1020

cccauucugc cucuccaggc uaaccugacc cgcaaaggag gcuggcugcc cacggggagc     1080

ccgucuguga uccuucagga cagauacucc ggauga                               1116


<210>  8150
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CREB3L1__Homo_sapiens__Q96BA8

<400>  8150

Met Asp Ala Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly 
1               5                   10                  15      


Ser Ser Phe Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn 
            20                  25                  30          


Asn Ala His Phe Pro Glu His Leu Asp His Phe Thr Glu Asn Met Glu 
        35                  40                  45              


Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu 
    50                  55                  60                  


Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Thr Pro 
65                  70                  75                  80  


Gly Ile Gln Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro 
                85                  90                  95      


Gln Ser Pro Leu Val Pro Ile Lys Met Glu Asp Thr Thr Gln Asp Ala 
            100                 105                 110         


Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile Met Val 
        115                 120                 125             


Lys Gln Glu Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro 
    130                 135                 140                 


Ser Ala Met Ala Ala Ala Ala Ala Met Ala Thr Thr Pro Leu Leu Gly 
145                 150                 155                 160 


Leu Ser Pro Leu Ser Arg Leu Pro Ile Pro His Gln Ala Pro Gly Glu 
                165                 170                 175     


Met Thr Gln Leu Pro Val Ile Lys Ala Glu Pro Leu Glu Val Asn Gln 
            180                 185                 190         


Phe Leu Lys Val Thr Pro Glu Asp Leu Val Gln Met Pro Pro Thr Pro 
        195                 200                 205             


Pro Ser Ser His Gly Ser Asp Ser Asp Gly Ser Gln Ser Pro Arg Ser 
    210                 215                 220                 


Leu Pro Pro Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Thr Ala 
225                 230                 235                 240 


Ile Ser Thr Ser Pro Leu Leu Thr Ala Pro His Lys Leu Gln Gly Thr 
                245                 250                 255     


Ser Gly Pro Leu Leu Leu Thr Glu Glu Glu Lys Arg Thr Leu Ile Ala 
            260                 265                 270         


Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Thr Lys Ala Glu Glu 
        275                 280                 285             


Lys Ala Leu Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala 
    290                 295                 300                 


Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys 
305                 310                 315                 320 


Lys Val Glu Thr Phe Thr Ser Glu Asn Asn Glu Leu Trp Lys Lys Val 
                325                 330                 335     


Glu Thr Leu Glu Asn Ala Asn Arg Thr Leu Leu Gln Gln Leu Gln Lys 
            340                 345                 350         


Leu Gln Thr Leu Val Thr Asn Lys Ile Ser Arg Pro Tyr Lys Met Ala 
        355                 360                 365             


Ala Thr Gln Thr Gly Thr Cys Leu Met Val Ala Ala Leu Cys Phe Val 
    370                 375                 380                 


Leu Val Leu Gly Ser Leu Val Pro Cys Leu Pro Glu Phe Ser Ser Gly 
385                 390                 395                 400 


Ser Gln Thr Val Lys Glu Asp Pro Leu Ala Ala Asp Gly Val Tyr Thr 
                405                 410                 415     


Ala Ser Gln Met Pro Ser Arg Ser Leu Leu Phe Tyr Asp Asp Gly Ala 
            420                 425                 430         


Gly Leu Trp Glu Asp Gly Arg Ser Thr Leu Leu Pro Met Glu Pro Pro 
        435                 440                 445             


Asp Gly Trp Glu Ile Asn Pro Gly Gly Pro Ala Glu Gln Arg Pro Arg 
    450                 455                 460                 


Asp His Leu Gln His Asp His Leu Asp Ser Thr His Glu Thr Thr Lys 
465                 470                 475                 480 


Tyr Leu Ser Glu Ala Trp Pro Lys Asp Gly Gly Asn Gly Thr Ser Pro 
                485                 490                 495     


Asp Phe Ser His Ser Lys Glu Trp Phe His Asp Arg Asp Leu Gly Pro 
            500                 505                 510         


Asn Thr Thr Ile Lys Leu Ser 
        515                 


<210>  8151
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8151
auggacgccg ucuuggaacc cuucccggcc gacaggcugu uccccggauc cagcuuccug       60

gacuuggggg aucugaacga gucggacuuc cucaacaaug cgcacuuucc ugagcaccug      120

gaccacuuua cggagaacau ggaggacuuc uccaaugacc uguucagcag cuucuuugau      180

gacccugugc uggaugagaa gagcccucua uuggacaugg aacuggacuc cccuacgcca      240

ggcauccagg cggagcacag cuacucccug agcggcgacu cagcgcccca gagcccccuu      300

gugcccauca agauggagga caccacccaa gaugcagagc auggagcaug ggcgcuggga      360

cacaaacugu gcuccaucau ggugaagcag gagcagagcc cggagcugcc cguggacccu      420

cuggcugccc ccucggccau ggcugccgcg gccgccaugg ccaccacccc gcugcugggc      480

cucagccccu uguccaggcu gcccaucccc caccaggccc cgggagagau gacucagcug      540

ccagugauca aagcagagcc ucuggaggug aaccaguucc ucaaagugac accggaggac      600

cuggugcaga ugccuccgac gccccccagc agccauggca gugacagcga cggcucccag      660

aguccccgcu cucugccccc cuccagcccu gucaggccca uggcgcgcuc cuccacggcc      720

aucuccaccu ccccacuccu cacugccccu cacaaauuac aggggacauc agggccacug      780

cuccugacag aggaggagaa gcggacccug auugcugagg gcuaccccau ccccacaaaa      840

cucccccuca ccaaagccga ggagaaggcc uugaagagag uccggaggaa aaucaagaac      900

aagaucucag cccaggagag ccgucguaag aagaaggagu auguggagug ucuagaaaag      960

aagguggaga cauuuacauc ugagaacaau gaacugugga agaaggugga gacccuggag     1020

aaugccaaca ggacccugcu ccagcagcug cagaaacucc agacucuggu caccaacaag     1080

aucuccagac cuuacaagau ggccgccacc cagacuggga ccugccucau gguggcagcc     1140

uugugcuuug uucuggugcu gggcucccuc gugcccugcc uucccgaguu cuccuccggc     1200

ucccagacug ugaaggaaga cccccuggcc gcagacggcg ucuacacggc cagccagaug     1260

cccucccgaa gccuccuauu cuacgaugac ggggcaggcu uaugggaaga uggccgcagc     1320

acccugcugc ccauggagcc cccagauggc ugggaaauca accccggggg gccggcagag     1380

cagcggcccc gggaccaccu gcagcaugau caccuggaca gcacccacga gaccaccaag     1440

uaccugagug aggccuggcc uaaagacggu ggaaacggca ccagccccga cuucucccac     1500

uccaaggagu gguuccacga cagggaucug ggccccaaca ccaccaucaa acucuccuag     1560


<210>  8152
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8152
auggacgccg ugcuggagcc cuucccggcc gaccgccucu uccccggcag cuccuuccug       60

gaccuggggg accucaacga gagcgacuuc cugaacaacg cgcacuuccc cgagcaccug      120

gaccacuuca ccgagaacau ggaggacuuc uccaacgacc ucuucagcuc cuucuucgac      180

gaccccgucc uggacgagaa guccccgcug cucgacaugg agcuggacag ccccaccccc      240

ggcauccagg ccgagcacag cuacucccug agcggggacu ccgcgcccca gagcccgcuc      300

gugcccauca agauggagga cacgacccag gacgccgagc acggcgccug ggcccugggg      360

cacaagcugu gcuccaucau ggugaagcag gagcagagcc ccgagcuccc cgucgacccg      420

cuggccgccc ccuccgccau ggcggccgcc gccgccaugg cgaccacgcc ccugcucggc      480

cugagccccc ugucccggcu cccgaucccc caccaggccc ccggcgagau gacccagcug      540

cccgugauca aggccgagcc gcuggaggug aaccaguucc ucaaggucac ccccgaggac      600

cuggugcaga ugccgcccac cccgcccagc ucccacggga gcgacagcga cggcucccag      660

agcccccgcu cccugccgcc cagcuccccc gugcggccca uggcccgcag cuccaccgcc      720

aucagcacga gcccccuccu gaccgcgccc cacaagcugc aggggaccuc cggcccccuc      780

cugcugaccg aggaggagaa gcggacgcuc aucgccgagg gguaccccau cccgaccaag      840

cugccccuga ccaaggccga ggagaaggcc cucaagcgcg uccggcgcaa gaucaagaac      900

aagaucuccg cccaggagag ccggcgcaag aagaaggagu acguggagug ccuggagaag      960

aagguggaga ccuucacguc cgagaacaac gagcugugga agaaggucga gacccucgag     1020

aacgcgaacc ggacccugcu gcagcagcuc cagaagcugc agacccuggu gacgaacaag     1080

aucagccgcc ccuacaagau ggccgccacc cagaccggga ccugccucau gguggccgcc     1140

cugugcuucg uccuggugcu cggcucccug gugcccugcc ugccggaguu cagcuccggc     1200

agccagacgg ucaaggagga cccccuggcg gccgacggcg uguacaccgc cucccagaug     1260

cccagccgga gccuccuguu cuacgacgac ggggccggcc ugugggagga cggccgcucc     1320

acccuccugc ccauggagcc gcccgacggg ugggagauca accccggcgg gcccgcggag     1380

cagcggccgc gcgaccaccu ccagcacgac caccuggaca gcacccacga gacgaccaag     1440

uaccuguccg aggccuggcc caaggacggc gggaacggca ccagccccga cuucucccac     1500

agcaaggagu gguuccacga ccgggaccug ggccccaaca ccacgaucaa gcucuccuga     1560


<210>  8153
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8153
auggacgccg uccucgagcc cuuccccgcc gaccgccucu uccccggcuc cuccuuccuc       60

gaccucggcg accucaacga guccgacuuc cucaacaacg cccacuuccc cgagcaccuc      120

gaccacuuca ccgagaacau ggaggacuuc uccaacgacc ucuucuccuc cuucuucgac      180

gaccccgucc ucgacgagaa guccccccuc cucgacaugg agcucgacuc ccccaccccc      240

ggcauccagg ccgagcacuc cuacucccuc uccggcgacu ccgcccccca guccccccuc      300

guccccauca agauggagga caccacccag gacgccgagc acggcgccug ggcccucggc      360

cacaagcucu gcuccaucau ggucaagcag gagcaguccc ccgagcuccc cgucgacccc      420

cucgccgccc ccuccgccau ggccgccgcc gccgccaugg ccaccacccc ccuccucggc      480

cucucccccc ucucccgccu ccccaucccc caccaggccc ccggcgagau gacccagcuc      540

cccgucauca aggccgagcc ccucgagguc aaccaguucc ucaaggucac ccccgaggac      600

cucguccaga ugccccccac cccccccucc ucccacggcu ccgacuccga cggcucccag      660

uccccccgcu cccucccccc cuccuccccc guccgcccca uggcccgcuc cuccaccgcc      720

aucuccaccu ccccccuccu caccgccccc cacaagcucc agggcaccuc cggcccccuc      780

cuccucaccg aggaggagaa gcgcacccuc aucgccgagg gcuaccccau ccccaccaag      840

cucccccuca ccaaggccga ggagaaggcc cucaagcgcg uccgccgcaa gaucaagaac      900

aagaucuccg cccaggaguc ccgccgcaag aagaaggagu acgucgagug ccucgagaag      960

aaggucgaga ccuucaccuc cgagaacaac gagcucugga agaaggucga gacccucgag     1020

aacgccaacc gcacccuccu ccagcagcuc cagaagcucc agacccucgu caccaacaag     1080

aucucccgcc ccuacaagau ggccgccacc cagaccggca ccugccucau ggucgccgcc     1140

cucugcuucg uccucguccu cggcucccuc guccccugcc uccccgaguu cuccuccggc     1200

ucccagaccg ucaaggagga cccccucgcc gccgacggcg ucuacaccgc cucccagaug     1260

cccucccgcu cccuccucuu cuacgacgac ggcgccggcc ucugggagga cggccgcucc     1320

acccuccucc ccauggagcc ccccgacggc ugggagauca accccggcgg ccccgccgag     1380

cagcgccccc gcgaccaccu ccagcacgac caccucgacu ccacccacga gaccaccaag     1440

uaccucuccg aggccuggcc caaggacggc ggcaacggca ccucccccga cuucucccac     1500

uccaaggagu gguuccacga ccgcgaccuc ggccccaaca ccaccaucaa gcucuccuga     1560


<210>  8154
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8154
auggacgccg ugcuggagcc cuucccugcu gauagacucu uuccaggcag cuccuuccuu       60

gaccuggggg auuugaacga aucugacuuu uuaaauaacg cacacuuccc ggagcaucug      120

gaucacuuua ccgaaaauau ggaggacuuc ucaaacgauc uauuuaguag cuucuuugac      180

gaucccgucc ucgacgaaaa guccccucug cuugauaugg agcuggacuc uccaacaccc      240

ggaauccagg ccgagcauuc guacucauug agcggugaua gugcgccuca auccccacuc      300

guucccauua aaauggaaga cacuacgcag gacgcugagc acggcgccug ggcacugggg      360

cauaagcugu gcucuauaau ggugaaacag gaacagagcc cugagcuccc aguagauccg      420

uuagccgcuc ccuccgcaau ggccgcugcc gcggcaaugg ccaccacacc ucugcuugga      480

uugucaccac ugaguaggcu acccaucccu caccaagcuc caggcgagau gacucagcuc      540

cccgugauua aggccgaacc gcuggagguc aaucaguucc uuaaagugac cccugaagac      600

cugguucaga ugcccccaac accucccagc ucucacgguu ccgauucaga cgggagccaa      660

aguccacggu cuuugccccc uuccagccca gugcgcccga uggcacgauc gucuaccgcu      720

aucuccacuu caccccuccu gacagccccu cauaaguuac agggaaccag uggcccacug      780

cuccuuacgg aggaagagaa gcguacucug auugcggagg gcuaucccau cccuaccaaa      840

uugccacuaa caaaggccga agagaaagca cugaagagag ucaggcggaa aauaaagaac      900

aagaucagcg cucaggaauc ccgcaggaaa aagaaagagu acguggaaug ucucgagaag      960

aaaguagaga cuuuuaccuc ugaaaauaac gagcugugga agaaaguuga aacacuugag     1020

aaugccaaca gaacccuguu gcagcaacuc cagaagcugc agacguuagu gacuaauaag     1080

auuagccggc ccuauaaaau ggcugccaca caaaccggga cuugccugau ggucgcagcc     1140

cuauguuucg ugcucgugcu gggaucacuu gucccgugcu ugccugaauu uaguuccggu     1200

agccagacag uuaaggagga uccacuggcu gcggacggcg uguacaccgc aucucagaug     1260

cccucacgca gucuccuguu cuaugaugac ggggccggac uuugggagga uggccgaagc     1320

acgcuguugc cuauggaacc cccagacggu ugggagauca acccuggggg acccgcugaa     1380

cagagaccaa gggaucaccu ccaacaugac caccuggacu ccacccacga gacaacuaaa     1440

uacuuaucug aggccuggcc gaaggauggc ggcaauggga ccucgccuga cuucagccau     1500

uccaaagaau gguuucacga ucgggaccug ggacccaaca caacuauuaa gcuaucauga     1560


<210>  8155
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8155
auggacgccg ugcuggagcc cuuccccgcc gacagacugu uccccggcag cagcuuccug       60

gaccugggcg accugaacga gagcgacuuc cugaacaacg cccacuuccc cgagcaccug      120

gaccacuuca ccgagaacau ggaggacuuc agcaacgacc uguucagcag cuucuucgac      180

gaccccgugc uggacgagaa gagcccccug cuggacaugg agcuggacag ccccaccccc      240

ggcauccagg ccgagcacag cuacagccug agcggcgaca gcgcccccca gagcccccug      300

gugcccauca agauggagga caccacccag gacgccgagc acggcgccug ggcccugggc      360

cacaagcugu gcagcaucau ggugaagcag gagcagagcc ccgagcugcc cguggacccc      420

cuggccgccc ccagcgccau ggccgccgcc gccgccaugg ccaccacccc ccugcugggc      480

cugagccccc ugagcagacu gcccaucccc caccaggccc ccggcgagau gacccagcug      540

cccgugauca aggccgagcc ccuggaggug aaccaguucc ugaaggugac ccccgaggac      600

cuggugcaga ugccccccac cccccccagc agccacggca gcgacagcga cggcagccag      660

agccccagaa gccugccccc cagcagcccc gugagaccca uggccagaag cagcaccgcc      720

aucagcacca gcccccugcu gaccgccccc cacaagcugc agggcaccag cggcccccug      780

cugcugaccg aggaggagaa gagaacccug aucgccgagg gcuaccccau ccccaccaag      840

cugccccuga ccaaggccga ggagaaggcc cugaagagag ugagaagaaa gaucaagaac      900

aagaucagcg cccaggagag cagaagaaag aagaaggagu acguggagug ccuggagaag      960

aagguggaga ccuucaccag cgagaacaac gagcugugga agaaggugga gacccuggag     1020

aacgccaaca gaacccugcu gcagcagcug cagaagcugc agacccuggu gaccaacaag     1080

aucagcagac ccuacaagau ggccgccacc cagaccggca ccugccugau gguggccgcc     1140

cugugcuucg ugcuggugcu gggcagccug gugcccugcc ugcccgaguu cagcagcggc     1200

agccagaccg ugaaggagga cccccuggcc gccgacggcg uguacaccgc cagccagaug     1260

cccagcagaa gccugcuguu cuacgacgac ggcgccggcc ugugggagga cggcagaagc     1320

acccugcugc ccauggagcc ccccgacggc ugggagauca accccggcgg ccccgccgag     1380

cagagaccca gagaccaccu gcagcacgac caccuggaca gcacccacga gaccaccaag     1440

uaccugagcg aggccuggcc caaggacggc ggcaacggca ccagccccga cuucagccac     1500

agcaaggagu gguuccacga cagagaccug ggccccaaca ccaccaucaa gcugagcuga     1560


<210>  8156
<211>  1560
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CREB3L1__Homo_sapiens__CCDS53620.1

<400>  8156
auggacgccg ugcuggagcc cuucccugcu gauagacucu uuccgggcag cuccuuccug       60

gaccuugggg aucugaacga aucugacuuu cucaauaacg cccacuuccc cgagcaucug      120

gaucacuuua ccgaaaauau ggaggacuuc agcaacgauc uguuuuccuc uuucuuugac      180

gauccugucc uugacgaaaa gagcccccuc cuggauaugg agcuggacuc cccuacaccc      240

ggaauccagg cggagcauuc uuacagccuc uccggcgaua gcgcuccuca aucuccgcug      300

guucccauua aaauggaaga cacgacccag gacgccgagc acggggccug ggcucuugga      360

cauaagcugu gcuccaucau ggugaaacag gaacagagcc cugagcuccc cguggauccu      420

cuggccgcuc ccucugccau ggcggccgcu gccgcuaugg ccacaacccc gcuucugggc      480

cucuccccuc ugagccggcu gcccauuccu caccaagcgc ccggggagau gacacagcuc      540

cccgucauca aggccgaacc ucuggaggug aaucaguucc uuaaaguuac cccggaagac      600

cuggugcaga ugcccccuac acccccuucu ucccacggaa gcgauuccga cggcucucaa      660

agcccccgcu cccucccgcc uagcucuccc gucagaccua uggcucgguc cagcaccgcc      720

auuucuacga gcccccugcu uaccgcuccu cauaagcugc agggcacauc cgggccccuc      780

cugcugaccg aggaagagaa gcgcacacuc aucgccgagg gauauccgau cccuaccaaa      840

cugccccuua cgaaggccga agagaaagcu cugaagagag ugcggcgcaa aauuaagaac      900

aagaucucug cgcaggaaag cagacggaaa aagaaagagu acguugaaug ucucgagaag      960

aaaguggaga cauuuaccuc cgaaaauaac gagcugugga agaaagucga aacacuugag     1020

aaugccaacc gcacccugcu ccagcaacug cagaagcugc agacccucgu gacaaauaag     1080

auuagcagac ccuauaaaau ggcugccacg caaaccggca caugccugau gguggccgcu     1140

cuuuguuucg uccugguucu cgggucucug gugccuugcc ugccggaauu uuccagcgga     1200

ucucagaccg ugaaggagga uccccuugcc gcggacggcg ucuacacagc uucccagaug     1260

ccuagccggu cccuccuguu cuaugaugac ggggccggac ugugggagga uggccgcucu     1320

acccuccugc ccauggaacc ucccgacggc ugggagauca acccuggggg acccgccgaa     1380

cagagaccgc gggaucaccu ucaacaugac caccuggaca gcacgcacga gacaaccaaa     1440

uaccucuccg aggcuuggcc uaaggauggc gggaauggaa ccucucccga cuucagccau     1500

uccaaagaau gguuucacga ucgcgaccug ggcccuaaca caaccauuaa gcugagcuga     1560


<210>  8157
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CREB3L3__Homo_sapiens__Q68CJ9

<400>  8157

Met Asn Thr Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Thr Pro Pro Arg Ser Gly Pro Ala Thr Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro 
        115                 120                 125             


Gly Asn Ser Cys Ser Thr Thr Thr Pro Gly Pro Val Ile Gln Val Pro 
    130                 135                 140                 


Glu Ala Ser Val Thr Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg 
145                 150                 155                 160 


Ile Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys 
                165                 170                 175     


Asn Leu Thr Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu 
            180                 185                 190         


Gln Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly 
        195                 200                 205             


His Cys Gln Glu Leu Val Leu Thr Glu Asp Glu Lys Lys Leu Leu Ala 
    210                 215                 220                 


Lys Glu Gly Ile Thr Leu Pro Thr Gln Leu Pro Leu Thr Lys Tyr Glu 
225                 230                 235                 240 


Glu Arg Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser 
                245                 250                 255     


Ala Gln Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu 
            260                 265                 270         


Thr Arg Met Ser Ala Cys Thr Ala Gln Asn Gln Glu Leu Gln Arg Lys 
        275                 280                 285             


Val Leu His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys 
    290                 295                 300                 


Lys Leu Gln Ala Ile Val Val Gln Ser Thr Ser Lys Ser Ala Gln Thr 
305                 310                 315                 320 


Gly Thr Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu 
                325                 330                 335     


Pro Ser Ile Ser Pro Phe Gly Pro Asn Lys Thr Glu Ser Pro Gly Asp 
            340                 345                 350         


Phe Ala Pro Val Arg Val Phe Ser Arg Thr Leu His Asn Asp Ala Ala 
        355                 360                 365             


Ser Arg Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro 
    370                 375                 380                 


Arg Pro Glu Ala Asp Thr Thr Arg Glu Glu Ser Pro Gly Ser Pro Gly 
385                 390                 395                 400 


Ala Asp Trp Gly Phe Gln Asp Thr Ala Asn Leu Thr Asn Ser Thr Glu 
                405                 410                 415     


Glu Leu Asp Asn Ala Thr Leu Val Leu Arg Asn Ala Thr Glu Gly Leu 
            420                 425                 430         


Gly Gln Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Thr Gly 
        435                 440                 445             


Ser Gly Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 460     


<210>  8158
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8158
augaauacgg auuuagcugc uggaaagaug gcuucugcug ccugcuccau ggaccccauc       60

gacagcuuug agcuccugga ucuccuguuu gaccggcagg acggcauccu gagacacgug      120

gagcugggcg agggcugggg ucacgucaag gaccagcagg uccugccaaa ccccgacucu      180

gacgacuucc ucagcuccau ccugggcucu ggagacucac ugcccagcuc cccacucugg      240

ucccccgaag gcagugauag uggcaucucc gaagaccucc ccuccgaccc ccaggacacc      300

ccuccacgca gcggaccagc caccuccccc gccggcugcc auccugccca gccuggcaag      360

gggcccugcc ucuccuauca uccuggcaac ucuugcucca ccacaacccc agggccagug      420

auccaaguac cugaagccuc ugugaccaua gaccuggaaa uguggagccc aggaggaagg      480

aucugugcug agaagccggc ugauccggug gaccuguccc cacgaugcaa ucucaccgug      540

aaagaccucc uccuuucggg cagcaguggg gaccugcaac agcaucaccu gggggccucc      600

uaccuccugc gaccuggggc ugggcacugu caggagcugg ugcucaccga ggaugagaag      660

aagcugcugg cuaaagaagg caucacccug cccacucagc ugccccucac uaaguacgag      720

gagcgagugc ugaaaaaaau ccgccggaaa auccggaaca agcagucggc gcaagaaagc      780

aggaagaaga agaaggaaua uaucgauggc cuggagacuc ggaugucagc uugcacugcu      840

cagaaucagg aguuacagag gaaagucuug caucucgaga agcaaaaccu gucccucuug      900

gagcaacuga agaaacucca ggccauugug gugcagucca ccagcaaguc agcccagaca      960

ggcaccugug ucgcaguccu guugcugucc uuugcccuca ucauccuccc cuccaucagc     1020

ccuuuuggcc ccaacaaaac cgagagcccu ggggacuuug cgccuguacg aguguucucc     1080

agaacuuugc acaacgaugc ugccucccgc guggcugcug augcugugcc aggcuccgag     1140

gccccaggac cccgacccga ggcugacaca acccgagaag agucuccagg aagccccggg     1200

gcagacuggg gcuuccagga caccgcgaac cugaccaauu cgacggagga gcuggacaac     1260

gccacccugg uccugaggaa ugcaacagag gggcugggcc aggucgcccu gcuggacugg     1320

guggcgccug ggccgagcac uggcucagga cgugcagggc uggaggcggc gggagacgag     1380

cuguga                                                                1386


<210>  8159
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8159
augaacaccg accuggccgc cggcaagaug gcgagcgccg ccugcuccau ggaccccauc       60

gacagcuucg agcuccugga ccuccuguuc gaccgccagg acgggauccu gcggcacgug      120

gagcugggcg aggggugggg ccacgucaag gaccagcagg uccucccgaa ccccgacucc      180

gacgacuucc ugagcuccau ccuggggagc ggcgacuccc uccccagcag cccccugugg      240

uccccggagg gcuccgacag cgggaucucc gaggaccugc ccagcgaccc ccaggacacg      300

cccccgcgcu ccggccccgc caccagcccc gccgggugcc accccgcgca gccgggcaag      360

gggcccugcc ucuccuacca ccccggcaac agcugcucca ccaccacccc cggcccggug      420

auccaggugc ccgaggccag cgugacgauc gaccuggaga uguggagccc cgggggccgg      480

aucugcgccg agaagcccgc cgacccggug gaccugagcc cccgcugcaa ccucaccguc      540

aaggaccugc ugcucuccgg guccagcggc gaccugcagc agcaccaccu gggcgcgucc      600

uaccuccugc ggcccggggc cggccacugc caggagcugg ugcucaccga ggacgagaag      660

aagcugcugg ccaaggaggg gaucacccuc cccacgcagc ugccgcugac caaguacgag      720

gagcgcgugc ucaagaagau ccggcgcaag auccggaaca agcagagcgc ccaggagucc      780

cgcaagaaga agaaggagua caucgacggc cuggagaccc ggaugagcgc cugcaccgcg      840

cagaaccagg agcugcagcg caagguccuc caccuggaga agcagaaccu gucccuccug      900

gagcagcuga agaagcucca ggccaucgug gugcagagca cguccaagag cgcccagacc      960

gggaccugcg ucgccgugcu gcugcucucc uucgcccuga ucauccugcc cagcaucucc     1020

cccuucggcc ccaacaagac cgagagcccg ggcgacuucg cgcccgugcg ggucuucucc     1080

cgcacgcucc acaacgacgc cgccagccgg guggccgccg acgcggugcc cggguccgag     1140

gccccgggcc cccgccccga ggccgacacc acccgggagg agagccccgg gagcccgggc     1200

gccgacuggg gguuccagga caccgccaac cugacgaacu ccaccgagga gcuggacaac     1260

gcgacccucg uccugcgcaa cgccaccgag ggccugggcc agguggcccu gcucgacugg     1320

guggcccccg ggcccagcac gggcuccggg cgggcgggcc uggaggccgc cggggacgag     1380

cuguga                                                                1386


<210>  8160
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8160
augaacaccg accucgccgc cggcaagaug gccuccgccg ccugcuccau ggaccccauc       60

gacuccuucg agcuccucga ccuccucuuc gaccgccagg acggcauccu ccgccacguc      120

gagcucggcg agggcugggg ccacgucaag gaccagcagg uccuccccaa ccccgacucc      180

gacgacuucc ucuccuccau ccucggcucc ggcgacuccc uccccuccuc cccccucugg      240

ucccccgagg gcuccgacuc cggcaucucc gaggaccucc ccuccgaccc ccaggacacc      300

cccccccgcu ccggccccgc caccuccccc gccggcugcc accccgccca gcccggcaag      360

ggccccugcc ucuccuacca ccccggcaac uccugcucca ccaccacccc cggccccguc      420

auccaggucc ccgaggccuc cgucaccauc gaccucgaga uguggucccc cggcggccgc      480

aucugcgccg agaagcccgc cgaccccguc gaccucuccc cccgcugcaa ccucaccguc      540

aaggaccucc uccucuccgg cuccuccggc gaccuccagc agcaccaccu cggcgccucc      600

uaccuccucc gccccggcgc cggccacugc caggagcucg uccucaccga ggacgagaag      660

aagcuccucg ccaaggaggg caucacccuc cccacccagc ucccccucac caaguacgag      720

gagcgcgucc ucaagaagau ccgccgcaag auccgcaaca agcaguccgc ccaggagucc      780

cgcaagaaga agaaggagua caucgacggc cucgagaccc gcauguccgc cugcaccgcc      840

cagaaccagg agcuccagcg caagguccuc caccucgaga agcagaaccu cucccuccuc      900

gagcagcuca agaagcucca ggccaucguc guccagucca ccuccaaguc cgcccagacc      960

ggcaccugcg ucgccguccu ccuccucucc uucgcccuca ucauccuccc cuccaucucc     1020

cccuucggcc ccaacaagac cgaguccccc ggcgacuucg cccccguccg cgucuucucc     1080

cgcacccucc acaacgacgc cgccucccgc gucgccgccg acgccguccc cggcuccgag     1140

gcccccggcc cccgccccga ggccgacacc acccgcgagg agucccccgg cucccccggc     1200

gccgacuggg gcuuccagga caccgccaac cucaccaacu ccaccgagga gcucgacaac     1260

gccacccucg uccuccgcaa cgccaccgag ggccucggcc aggucgcccu ccucgacugg     1320

gucgcccccg gccccuccac cggcuccggc cgcgccggcc ucgaggccgc cggcgacgag     1380

cucuga                                                                1386


<210>  8161
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8161
augaacaccg accuggccgc uggcaagaug gcaagcgccg cgugcuccau ggaucccauc       60

gacucuuucg agcuccuuga ucuguuguuu gacagacagg augggauuuu aaggcacgug      120

gaacugggag aggguugggg ccaugucaaa gaccaacagg uucuaccuaa uccagauuca      180

gacgauuucc ucaguagcau acuggggucc ggagacucuc uuccgucguc accccugugg      240

agcccugaag gcagugauuc cgguaucucu gaggacuugc caagcgaucc ccaggacaca      300

ccuccacggu ccgggcccgc uacuucacca gccggauguc acccugcaca gccgggcaag      360

ggccccugcc ucaguuacca uccugggaac agcuguucua cgaccacacc aggacccgug      420

auucaaguac cugaagccuc cgugacuauc gaccuggaga uguggucacc agguggccgc      480

auuugcgcug agaaacccgc agauccgguc gaccugagcc cucgauguaa ucucaccgug      540

aaggauuuac ugcuuagugg gucuuccgga gacuugcagc agcaccaucu gggcgccagc      600

uaucuacucc gucccggugc ugggcacugc caggaacugg uucuuacaga ggaugagaaa      660

aagcuguugg ccaaggaagg aaucacccuc ccaacucaac ugccuuuaac aaaauacgag      720

gaaagagugc ugaagaaaau aaggcggaag auccgcaaca aacagucggc gcaggagucu      780

agaaagaaga aaaaggaaua uauugacggc cucgagacca ggauguccgc auguacggcc      840

cagaaucaag aacuucagcg gaaaguccug cacuuggaga agcagaaccu aucacugcuc      900

gagcaacuga aaaagcugca ggcuaucgug guacagagua cuagcaaauc cgcccagacc      960

ggcacaugcg uugcagugcu uuugcucucu uuugcucuga uuaucuuacc cagcauauca     1020

ccauucgggc ccaauaagac ugaaaguccu ggagauuuug ccccaguccg cguguucucc     1080

cgaacccugc auaacgacgc ggccagcaga guggcagcug augccguccc ggguucugag     1140

gcucccggcc cuaggccaga agccgacaca acccgggagg aaucacccgg gaguccugga     1200

gcagauuggg gcuuucaaga cacggccaau cuaacuaaca gcacagagga gcucgacaau     1260

gcuacccugg uucuucguaa cgcgacugaa gguuugggcc agguggcacu gcucgauugg     1320

guagccccag ggcccuccac aggaucuggc cgcgcugggc uggaggccgc aggagacgaa     1380

cuuuga                                                                1386


<210>  8162
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8162
augaacaccg accuggccgc cggcaagaug gccagcgccg ccugcagcau ggaccccauc       60

gacagcuucg agcugcugga ccugcuguuc gacagacagg acggcauccu gagacacgug      120

gagcugggcg agggcugggg ccacgugaag gaccagcagg ugcugcccaa ccccgacagc      180

gacgacuucc ugagcagcau ccugggcagc ggcgacagcc ugcccagcag cccccugugg      240

agccccgagg gcagcgacag cggcaucagc gaggaccugc ccagcgaccc ccaggacacc      300

ccccccagaa gcggccccgc caccagcccc gccggcugcc accccgccca gcccggcaag      360

ggccccugcc ugagcuacca ccccggcaac agcugcagca ccaccacccc cggccccgug      420

auccaggugc ccgaggccag cgugaccauc gaccuggaga uguggagccc cggcggcaga      480

aucugcgccg agaagcccgc cgaccccgug gaccugagcc ccagaugcaa ccugaccgug      540

aaggaccugc ugcugagcgg cagcagcggc gaccugcagc agcaccaccu gggcgccagc      600

uaccugcuga gacccggcgc cggccacugc caggagcugg ugcugaccga ggacgagaag      660

aagcugcugg ccaaggaggg caucacccug cccacccagc ugccccugac caaguacgag      720

gagagagugc ugaagaagau cagaagaaag aucagaaaca agcagagcgc ccaggagagc      780

agaaagaaga agaaggagua caucgacggc cuggagacca gaaugagcgc cugcaccgcc      840

cagaaccagg agcugcagag aaaggugcug caccuggaga agcagaaccu gagccugcug      900

gagcagcuga agaagcugca ggccaucgug gugcagagca ccagcaagag cgcccagacc      960

ggcaccugcg uggccgugcu gcugcugagc uucgcccuga ucauccugcc cagcaucagc     1020

cccuucggcc ccaacaagac cgagagcccc ggcgacuucg cccccgugag aguguucagc     1080

agaacccugc acaacgacgc cgccagcaga guggccgccg acgccgugcc cggcagcgag     1140

gcccccggcc ccagacccga ggccgacacc accagagagg agagccccgg cagccccggc     1200

gccgacuggg gcuuccagga caccgccaac cugaccaaca gcaccgagga gcuggacaac     1260

gccacccugg ugcugagaaa cgccaccgag ggccugggcc agguggcccu gcuggacugg     1320

guggcccccg gccccagcac cggcagcggc agagccggcc uggaggccgc cggcgacgag     1380

cuguga                                                                1386


<210>  8163
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CREB3L3__Homo_sapiens__CCDS12121.1

<400>  8163
augaacaccg accuggccgc uggcaagaug gccagcgcgg cuugcuccau ggaucccauc       60

gacucuuucg agcuccugga ucuucuguuu gacagacagg augggauucu ccggcacgug      120

gaacugggag agggcugggg gcaugucaaa gaccaacagg uucuuccuaa uccggauagc      180

gacgauuucc uguccucuau ccucggaagc ggcgacuccc ugcccucuag cccucugugg      240

ucccccgaag ggagcgauuc uggaauuucc gaggaccucc cuagcgaucc ccaggacaca      300

ccuccgcgcu cuggccccgc cacguccccu gccggcuguc accccgcuca gccugggaag      360

ggacccugcc ugagcuacca uccgggcaac ucuuguucca ccacaacccc ugggcccgug      420

auccaagugc cugaagccag cgucacaauu gaccuugaga uguggucccc cggaggcaga      480

aucugcgcug agaaacccgc cgauccugug gaccugucuc cgcgguguaa ucucaccguu      540

aaggaucugc uucugagcgg guccagcgga gaccuccagc agcaccaucu gggcgcgucu      600

uaucugcucc gccccggcgc cgggcacugc caggaacugg ugcuuacaga ggaugagaaa      660

aagcugcucg cuaaggaagg aaucacccug ccuacgcaac uuccccugac caaauacgag      720

gaaagagucc ucaagaaaau ucggcgcaag aucagaaaca aacaguccgc ccaggagagc      780

cggaagaaga aaaaggaaua uauugacggc cuggagacac gcaugucugc uuguaccgcc      840

cagaaucaag aacugcagag aaaagugcuc caccuggaga agcagaaccu uagccugcuc      900

gagcaacuga aaaagcugca ggcgaucguu gugcagucca caucuaaaag cgcccagacc      960

gggacgugcg ucgcugugcu ucuccugucc uuugcccuga uuauccuccc uagcauuucu     1020

cccuucggac cgaauaagac agaauccccu ggcgauuuug cucccgugcg ggucuucagc     1080

cgcacccugc auaacgacgc cgccucuaga guugcugcgg augccgugcc uggguccgag     1140

gcucccggac cucggcccga agccgacaca acccgcgagg aaagcccggg cuccccuggc     1200

gccgauuggg gguuucaaga caccgcuaau cuuacaaacu cuacggagga gcuggacaau     1260

gccacccucg ugcugagaaa cgcgacagaa ggacugggcc aggucgcccu ucucgauugg     1320

guggcucccg ggcccagcac cggauccggc cgggccgggc uggaggcugc cggcgacgaa     1380

cuguga                                                                1386


<210>  8164
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CREB3L4__Homo_sapiens__Q8TEY5

<400>  8164

Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 


<210>  8165
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8165
auggaucucg gaaucccuga ccugcuggac gcguggcugg agcccccaga ggauaucuuc       60

ucgacaggau ccguccugga gcugggacuc cacugccccc cuccagaggu uccgguaacu      120

aggcuacagg aacagggacu gcaaggcugg aaguccggug gggaccgugg cuguggccuu      180

caagagagug agccugaaga uuucuugaag cuuuucauug aucccaauga gguguacugc      240

ucagaagcau cuccuggcag ugacaguggc aucucugagg accccugcca uccagacagu      300

cccccugccc ccagggcaac caguucuccu augcucuaug agguugucua ugaggcaggg      360

gcccuggaga ggaugcaggg ggaaacuggg ccaaauguag gccuuaucuc cauccagcua      420

gaucagugga gcccagcauu uauggugccu gauuccugca uggucaguga gcugcccuuu      480

gaugcucaug cccacauccu gcccagagca ggcaccguag ccccagugcc cuguacaacc      540

cugcugcccu gucaaacccu guuccugacc gaugaggaga agcgucugcu ggggcaggaa      600

gggguuuccc ugcccucuca ccugccccuc accaaggcag aggagagggu ccucaagaag      660

gucaggagga aaauccguaa caagcaguca gcucaggaca gucggcggcg gaagaaggag      720

uacauugaug ggcuggagag caggguggca gccuguucug cacagaacca agaauuacag      780

aaaaaagucc aggagcugga gaggcacaac aucuccuugg uagcucagcu ccgccagcug      840

cagacgcuaa uugcucaaac uuccaacaaa gcugcccaga ccagcacuug uguuuugauu      900

cuucuuuuuu cccuggcucu caucauccug cccagcuuca guccauucca gagucgacca      960

gaagcugggu cugaggauua ccagccucac ggagugacuu ccagaaauau ccugacccac     1020

aaggacguaa cagaaaaucu ggagacccaa gugguagagu ccagacugag ggagccaccu     1080

ggagccaagg augcaaaugg cucaacaagg acacugcuug agaagauggg agggaagcca     1140

agacccagug ggcgcauccg guccgugcug caugcagaug agauguga                  1188


<210>  8166
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8166
auggaccugg gcauccccga ccuccuggac gccuggcugg agccgcccga ggacaucuuc       60

agcaccgggu ccgugcucga gcugggccug cacugcccgc ccccggaggu ccccgugacc      120

cgccuccagg agcaggggcu gcagggcugg aaguccgggg gcgaccgggg cugcgggcug      180

caggagagcg agcccgagga cuuccucaag cuguucaucg accccaacga gguguacugc      240

agcgaggccu ccccgggcag cgacuccggg aucagcgagg accccugcca ccccgacucc      300

ccgcccgcgc cccgcgccac gagcuccccc augcuguacg aggucgugua cgaggccggc      360

gcccucgagc ggaugcaggg ggagaccggc cccaacgugg gccugaucag cauccagcug      420

gaccaguggu cccccgccuu cauggucccc gacagcugca ugguguccga gcuccccuuc      480

gacgcgcacg cccacauccu gccccgcgcc gggaccgugg ccccgguccc cugcaccacg      540

cugcuccccu gccagacccu guuccugacc gacgaggaga agcggcuccu gggccaggag      600

ggggugagcc ugcccuccca ccucccgcug accaaggcgg aggagcgcgu gcugaagaag      660

guccggcgca agauccggaa caagcagagc gcccaggacu cccgccggcg caagaaggag      720

uacaucgacg gccucgagag ccggguggcc gccugcagcg cccagaacca ggagcugcag      780

aagaaggugc aggagcugga gcgccacaac aucucccucg ucgcgcagcu gcggcagcug      840

cagacgcuca ucgcccagac cagcaacaag gccgcccaga ccuccacgug cgugcugauc      900

cuccuguuca gccuggcccu gaucauccuc cccuccuuca gccccuucca gucccgcccc      960

gaggcgggca gcgaggacua ccagccgcac ggggugaccu cccggaacau ccugacccac     1020

aaggacguca ccgagaaccu ggagacccag gugguggaga gccgccuccg ggagccgccc     1080

ggcgccaagg acgccaacgg guccacgcgc acccugcugg agaagauggg cgggaagccc     1140

cggcccagcg gccgcauccg cuccguccuc cacgccgacg agauguga                  1188


<210>  8167
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8167
auggaccucg gcauccccga ccuccucgac gccuggcucg agccccccga ggacaucuuc       60

uccaccggcu ccguccucga gcucggccuc cacugccccc cccccgaggu ccccgucacc      120

cgccuccagg agcagggccu ccagggcugg aaguccggcg gcgaccgcgg cugcggccuc      180

caggaguccg agcccgagga cuuccucaag cucuucaucg accccaacga ggucuacugc      240

uccgaggccu cccccggcuc cgacuccggc aucuccgagg accccugcca ccccgacucc      300

ccccccgccc cccgcgccac cuccuccccc augcucuacg aggucgucua cgaggccggc      360

gcccucgagc gcaugcaggg cgagaccggc cccaacgucg gccucaucuc cauccagcuc      420

gaccaguggu cccccgccuu cauggucccc gacuccugca uggucuccga gcuccccuuc      480

gacgcccacg cccacauccu cccccgcgcc ggcaccgucg cccccguccc cugcaccacc      540

cuccuccccu gccagacccu cuuccucacc gacgaggaga agcgccuccu cggccaggag      600

ggcgucuccc uccccuccca ccucccccuc accaaggccg aggagcgcgu ccucaagaag      660

guccgccgca agauccgcaa caagcagucc gcccaggacu cccgccgccg caagaaggag      720

uacaucgacg gccucgaguc ccgcgucgcc gccugcuccg cccagaacca ggagcuccag      780

aagaaggucc aggagcucga gcgccacaac aucucccucg ucgcccagcu ccgccagcuc      840

cagacccuca ucgcccagac cuccaacaag gccgcccaga ccuccaccug cguccucauc      900

cuccucuucu cccucgcccu caucauccuc cccuccuucu cccccuucca gucccgcccc      960

gaggccggcu ccgaggacua ccagccccac ggcgucaccu cccgcaacau ccucacccac     1020

aaggacguca ccgagaaccu cgagacccag gucgucgagu cccgccuccg cgagcccccc     1080

ggcgccaagg acgccaacgg cuccacccgc acccuccucg agaagauggg cggcaagccc     1140

cgccccuccg gccgcauccg cuccguccuc cacgccgacg agauguga                  1188


<210>  8168
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8168
auggaccugg gcauccccga ucuccuugac gccuggcugg agccuccaga agauauuuuc       60

agcaccgggu ccguguugga guuaggacug cacugcccgc ccccugaagu cccaguuaca      120

agacuacagg agcaaggucu ccagggcugg aagucugggg gagacagggg cuguggucug      180

caggaaucag agcccgagga uuuucuuaaa cuguucauag acccuaacga aguguacugc      240

agugaggcua gcccaggguc cgauucugga aucucggaag accccuguca uccugauuca      300

ccaccggcac cccgggccac uagcaguccu auguuguaug agguagugua cgaggcgggc      360

gcucucgaac gcaugcaggg cgagacgggg ccaaaugucg gacugauuuc cauccaacug      420

gaccaguggu cucccgccuu uauggugccu gauagcugca ugguuuccga acucccauuc      480

gacgcacacg cccauauuuu accccgagcu gguaccgugg caccgguccc uuguacaacu      540

cugcuucccu gccagaccuu guuucugaca gaugaggaaa agcgucuacu cggccaggag      600

ggggugucac ugccaaguca ccuuccucug accaaagccg aggaaagagu auugaagaaa      660

guuaggcgga agauccgcaa caagcaaagc gcucaggacu cuagaaggcg gaaaaaggag      720

uauauagacg gacucgaauc ccgcguggcc gcguguucag cacagaauca ggagcugcag      780

aaaaaggucc aagaauuaga gcgacauaac aucagccugg uggcccagcu cagacaacuu      840

cagacucuga uugcucagac aaguaauaaa gccgcacaga ccucuacgug cguguugauc      900

cuacuguucu cccucgcucu gauuauccuu cccagcuuuu cgccauucca aucuaggccc      960

gaggccggcu ccgaagauua ccagccucac ggugucacuu cacggaacau acugacccac     1020

aaggacguua cagagaauuu ggaaacucag gugguagaga gucgucuccg cgaaccaccg     1080

ggggcgaagg augccaacgg aagcaccaga acacuguuag agaaaauggg cggcaagccc     1140

aggccuuccg ggcggauucg aucugugcug caugcagacg agauguga                  1188


<210>  8169
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8169
auggaccugg gcauccccga ccugcuggac gccuggcugg agccccccga ggacaucuuc       60

agcaccggca gcgugcugga gcugggccug cacugccccc cccccgaggu gcccgugacc      120

agacugcagg agcagggccu gcagggcugg aagagcggcg gcgacagagg cugcggccug      180

caggagagcg agcccgagga cuuccugaag cuguucaucg accccaacga gguguacugc      240

agcgaggcca gccccggcag cgacagcggc aucagcgagg accccugcca ccccgacagc      300

ccccccgccc ccagagccac cagcagcccc augcuguacg agguggugua cgaggccggc      360

gcccuggaga gaaugcaggg cgagaccggc cccaacgugg gccugaucag cauccagcug      420

gaccagugga gccccgccuu cauggugccc gacagcugca uggugagcga gcugcccuuc      480

gacgcccacg cccacauccu gcccagagcc ggcaccgugg cccccgugcc cugcaccacc      540

cugcugcccu gccagacccu guuccugacc gacgaggaga agagacugcu gggccaggag      600

ggcgugagcc ugcccagcca ccugccccug accaaggccg aggagagagu gcugaagaag      660

gugagaagaa agaucagaaa caagcagagc gcccaggaca gcagaagaag aaagaaggag      720

uacaucgacg gccuggagag cagaguggcc gccugcagcg cccagaacca ggagcugcag      780

aagaaggugc aggagcugga gagacacaac aucagccugg uggcccagcu gagacagcug      840

cagacccuga ucgcccagac cagcaacaag gccgcccaga ccagcaccug cgugcugauc      900

cugcuguuca gccuggcccu gaucauccug cccagcuuca gccccuucca gagcagaccc      960

gaggccggca gcgaggacua ccagccccac ggcgugacca gcagaaacau ccugacccac     1020

aaggacguga ccgagaaccu ggagacccag gugguggaga gcagacugag agagcccccc     1080

ggcgccaagg acgccaacgg cagcaccaga acccugcugg agaagauggg cggcaagccc     1140

agacccagcg gcagaaucag aagcgugcug cacgccgacg agauguga                  1188


<210>  8170
<211>  1188
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CREB3L4__Homo_sapiens__CCDS1056.1

<400>  8170
auggaccugg gcauccccga ucuccuggac gccuggcuug agccuccgga agauauuuuc       60

agcaccgggu ccgugcugga gcucggacug cacugucccc cucccgaagu cccuguuaca      120

agacuucagg agcaaggccu gcaggggugg aagucuggag gcgaccgggg gugcggacuc      180

caggaaagcg agcccgagga uuuucugaaa cuguucaucg acccuaacga aguguacugc      240

uccgaggcuu cuccgggcag cgauuccggc auuucugaag accccuguca uccugauagc      300

ccucccgccc ccagagcgac guccagcccg augcucuaug agguggucua cgaggcuggg      360

gcccuggaaa gaaugcaggg agagaccggc ccuaaugugg ggcuuaucuc uauucaacug      420

gaccaguggu cccccgccuu uaugguuccu gauagcugca uggugucuga acuccccuuc      480

gacgcucacg cccauauccu gccccgggcu ggaacagucg ccccugugcc guguaccaca      540

cuucugcccu gccagacccu cuuucugaca gaugaggaaa agcgccugcu cggccaggag      600

gggguuuccc ugccuagcca ccuuccccug accaaagcgg aggaaagagu gcucaagaaa      660

guccggcgca agaucagaaa caagcaaucu gcccaggacu cccggcgccg caaaaaggag      720

uauauugacg gacuggaaag ccggguggcu gccuguuccg cucagaauca ggagcuucag      780

aaaaaggugc aagaacugga gcgccauaac aucucucucg ucgcccagcu gagacaacug      840

cagacgcuca uugcgcagac cagcaauaaa gccgcucaga cauccacaug cguucugauc      900

cuucuguuca gccucgcccu gauuauccuu ccuucuuuuu cccccuucca aagccggccg      960

gaggcuggcu cugaagauua ccagccucac ggcgugacca gccgcaacau ucugacccac     1020

aaggacguga cggagaaucu cgaaacacag gucguggagu ccagacugcg ggaacccccu     1080

ggggccaagg augccaacgg aucuaccaga acacugcucg agaaaauggg cgggaagccc     1140

cgcccuagcg gacggaucag auccguucug caugcugacg agauguga                  1188


<210>  8171
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CREB5__Homo_sapiens__Q02930

<400>  8171

Met Ile Tyr Glu Glu Ser Lys Met Asn Leu Glu Gln Glu Arg Pro Phe 
1               5                   10                  15      


Val Cys Ser Ala Pro Gly Cys Ser Gln Arg Phe Pro Thr Glu Asp His 
            20                  25                  30          


Leu Met Ile His Arg His Lys His Glu Met Thr Leu Lys Phe Pro Ser 
        35                  40                  45              


Ile Lys Thr Asp Asn Met Leu Ser Asp Gln Thr Pro Thr Pro Thr Arg 
    50                  55                  60                  


Phe Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Ser Glu Leu Asp Cys 
65                  70                  75                  80  


Ser Leu Glu His Glu Phe Arg Lys Ala Gln Glu Glu Glu Ser Ser Lys 
                85                  90                  95      


Arg Asn Ile Ser Met His Asn Ala Val Gly Gly Ala Met Thr Gly Pro 
            100                 105                 110         


Gly Thr His Gln Leu Ser Ser Ala Arg Leu Pro Asn His Asp Thr Asn 
        115                 120                 125             


Val Val Ile Gln Gln Ala Met Pro Ser Pro Gln Ser Ser Ser Val Ile 
    130                 135                 140                 


Thr Gln Ala Pro Ser Thr Asn Arg Gln Ile Gly Pro Val Pro Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Leu Leu His Leu His Asn Arg Gln Arg Gln Pro Met Pro 
                165                 170                 175     


Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr Met Pro Gly Ser Ser 
            180                 185                 190         


Ala Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser Ser Ile 
        195                 200                 205             


Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser Pro Gln 
    210                 215                 220                 


Val Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu 
225                 230                 235                 240 


Thr His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Thr Met Gly 
                245                 250                 255     


His Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Thr Pro His His 
            260                 265                 270         


His Met His Ser His Pro His Gln His Gln Thr Leu Pro Pro His His 
        275                 280                 285             


Pro Tyr Pro His Gln His Gln His Pro Ala His His Pro His Pro Gln 
    290                 295                 300                 


Pro His His Gln Gln Asn His Pro His His His Ser His Ser His Leu 
305                 310                 315                 320 


His Ala His Pro Ala His His Gln Thr Ser Pro His Pro Pro Leu His 
                325                 330                 335     


Thr Gly Asn Gln Ala Gln Val Ser Pro Ala Thr Gln Gln Met Gln Pro 
            340                 345                 350         


Thr Gln Thr Ile Gln Pro Pro Gln Pro Thr Gly Gly Arg Arg Arg Arg 
        355                 360                 365             


Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu Glu Arg 
    370                 375                 380                 


Asn Arg Ala Ala Ala Thr Arg Cys Arg Gln Lys Arg Lys Val Trp Val 
385                 390                 395                 400 


Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Gln Thr Asn Met Gln 
                405                 410                 415     


Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys 
            420                 425                 430         


Gln Leu Leu Leu Thr His Lys Asp Cys Pro Ile Thr Ala Met Gln Lys 
        435                 440                 445             


Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser Pro Pro Ala Ser Pro 
    450                 455                 460                 


Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln His Asn Thr Ile Thr 
465                 470                 475                 480 


Thr Ser Ser Ser Val Ser Glu Val Val Gly Ser Ser Thr Leu Ser Gln 
                485                 490                 495     


Leu Thr Thr His Arg Thr Asp Leu Asn Pro Ile Leu 
            500                 505             


<210>  8172
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CREB5__Homo_sapiens__CCDS5417.1

<400>  8172
augauuuaug aggaauccaa gaugaauuug gagcaggaga ggccguuugu cugcagugcc       60

ccaggcugcu cccagcgcuu cccaacagag gaccaucuga ugauucauag gcacaaacau      120

gaaaugacuu ugaaguuucc uucaauaaaa acagacaaua uguuaucaga ucaaacuccg      180

accccaacga gauuccugaa gaacugcgag gaggugggcc ucuucagcga gcuggacugc      240

ucccuggagc acgaguucag gaaggcucag gaagaggaga gcagcaagcg gaauaucucg      300

augcauaaug caguuggugg ggccaugacg gggcccggaa cucaccagcu uagcagcgcu      360

cggcugccca accaugacac caacguugug auucagcaag ccaugccguc gccucagucc      420

agcucuguca ucacucaggc accuuccacc aaccgccaga ucgggccugu cccaggcucu      480

cuaucuucuc ugcuacaucu ccacaacaga cagagacagc ccaugccagc cuccaugccu      540

gggacccugc ccaacccuac aaugccagga ucuuccgccg ucuugaugcc aauggagcga      600

caaaugucag ugaacuccag caucaugggg augcaagguc caaaucucag caaccccugu      660

gcuucucccc agguccagcc aaugcauuca gaagccaaaa ugagguugaa ggcugcauug      720

acucaccacc cugcugccau gucaaauggg aacaugaaca ccaugggaca caugauggag      780

augaugggcu cccggcagga ccagacgcca caccaucaca ugcacucgca cccgcaucag      840

caccagacac ugccacccca ucacccuuac ccacaccagc accagcaccc agcacaccau      900

ccucacccuc aaccccauca ccagcagaac cauccacauc accacuccca uucccaccuu      960

caugcacacc cagcacauca ccagaccucg ccacauccgc cccugcacac cggcaaccaa     1020

gcacagguuu caccagcaac acaacagaug cagccaaccc agacaauaca gccaccccag     1080

cccacagggg ggcgccggcg aaggguggua gacgaggauc cggacgagag gcggcggaaa     1140

uuucuggaac ggaaccgggc agcugccacc cgcugcagac agaagaggaa ggucugggug     1200

augucauugg aaaagaaagc agaagaacuc acccagacaa acaugcagcu ucagaaugaa     1260

gugucuaugu ugaaaaauga gguggcccag cugaaacagu uguuguuaac acauaaagac     1320

ugcccaauaa cagccaugca gaaagaauca caaggauauc uaaguccaga gaguagcccu     1380

ccugcuaguc cugucccagc uugcucccag caacaaguca uccagcauaa uaccaucacu     1440

acuuccucau cggucagcga ggugguagga agcuccaccc ucagccagcu caccacucac     1500

agaacagacc ugaauccgau ucuuuaa                                         1527


<210>  8173
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CREB5__Homo_sapiens__CCDS5417.1

<400>  8173
augaucuacg aggagagcaa gaugaaccug gagcaggagc gccccuucgu gugcuccgcc       60

ccgggcugca gccagcgguu ccccaccgag gaccaccuca ugauccaccg ccacaagcac      120

gagaugaccc ugaaguuccc cuccaucaag acggacaaca ugcugagcga ccagaccccc      180

accccgaccc gguuccucaa gaacugcgag gaggucgggc uguucuccga gcuggacugc      240

agccucgagc acgaguuccg caaggcccag gaggaggagu ccagcaagcg gaacaucucc      300

augcacaacg cggugggcgg ggccaugacg ggccccggga cccaccagcu gagcuccgcc      360

cgccugccca accacgacac caacgugguc auccagcagg ccaugcccag cccgcagucc      420

agcuccguga ucacccaggc ccccagcacg aaccggcaga ucggccccgu gcccggcucc      480

cucagcuccc ugcugcaccu ccacaaccgc cagcggcagc cgaugcccgc gagcaugccc      540

gggacccugc ccaacccgac caugcccggc agcuccgccg uccugaugcc cauggagcgc      600

cagaugagcg ugaacuccag caucaugggg augcagggcc ccaaccucuc caacccgugc      660

gccagccccc aggugcagcc caugcacucc gaggccaaga ugcggcugaa ggcggcccug      720

acccaccacc ccgccgccau gagcaacggg aacaugaaca cgaugggcca caugauggag      780

augaugggcu cccgccagga ccagaccccg caccaccaca ugcacagcca cccccaccag      840

caccagaccc ucccgcccca ccaccccuac ccccaccagc accagcaccc cgcccaccac      900

ccgcaccccc agccccacca ccagcagaac cacccccacc accacuccca cagccaccuc      960

cacgcgcacc cggcccacca ccagaccagc ccccacccgc cccugcacac ggggaaccag     1020

gcccaggucu cccccgccac ccagcagaug cagcccaccc agaccaucca gccgccccag     1080

cccacgggcg ggcggcgccg gcgcguggug gacgaggacc ccgacgagcg gcgccggaag     1140

uuccuggagc gcaaccgggc cgcggccacc cgcugccgcc agaagcggaa ggucugggug     1200

augucccugg agaagaaggc cgaggagcug acccagacca acaugcagcu ccagaacgag     1260

gugagcaugc ugaagaacga ggucgcccag cugaagcagc uccugcugac gcacaaggac     1320

ugccccauca ccgccaugca gaaggagucc cagggcuacc ucagccccga guccagcccg     1380

cccgcgagcc ccgugcccgc cugcucccag cagcagguca uccagcacaa caccaucacc     1440

acgagcucca gcguguccga gguggugggc agcuccaccc ugagccagcu gaccacccac     1500

cgcacggacc ucaacccgau ccuguga                                         1527


<210>  8174
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CREB5__Homo_sapiens__CCDS5417.1

<400>  8174
augaucuacg aggaguccaa gaugaaccuc gagcaggagc gccccuucgu cugcuccgcc       60

cccggcugcu cccagcgcuu ccccaccgag gaccaccuca ugauccaccg ccacaagcac      120

gagaugaccc ucaaguuccc cuccaucaag accgacaaca ugcucuccga ccagaccccc      180

acccccaccc gcuuccucaa gaacugcgag gaggucggcc ucuucuccga gcucgacugc      240

ucccucgagc acgaguuccg caaggcccag gaggaggagu ccuccaagcg caacaucucc      300

augcacaacg ccgucggcgg cgccaugacc ggccccggca cccaccagcu cuccuccgcc      360

cgccucccca accacgacac caacgucguc auccagcagg ccaugcccuc cccccagucc      420

uccuccguca ucacccaggc ccccuccacc aaccgccaga ucggccccgu ccccggcucc      480

cucuccuccc uccuccaccu ccacaaccgc cagcgccagc ccaugcccgc cuccaugccc      540

ggcacccucc ccaaccccac caugcccggc uccuccgccg uccucaugcc cauggagcgc      600

cagauguccg ucaacuccuc caucaugggc augcagggcc ccaaccucuc caaccccugc      660

gccucccccc agguccagcc caugcacucc gaggccaaga ugcgccucaa ggccgcccuc      720

acccaccacc ccgccgccau guccaacggc aacaugaaca ccaugggcca caugauggag      780

augaugggcu cccgccagga ccagaccccc caccaccaca ugcacuccca cccccaccag      840

caccagaccc ucccccccca ccaccccuac ccccaccagc accagcaccc cgcccaccac      900

ccccaccccc agccccacca ccagcagaac cacccccacc accacuccca cucccaccuc      960

cacgcccacc ccgcccacca ccagaccucc ccccaccccc cccuccacac cggcaaccag     1020

gcccaggucu cccccgccac ccagcagaug cagcccaccc agaccaucca gcccccccag     1080

cccaccggcg gccgccgccg ccgcgucguc gacgaggacc ccgacgagcg ccgccgcaag     1140

uuccucgagc gcaaccgcgc cgccgccacc cgcugccgcc agaagcgcaa ggucuggguc     1200

augucccucg agaagaaggc cgaggagcuc acccagacca acaugcagcu ccagaacgag     1260

gucuccaugc ucaagaacga ggucgcccag cucaagcagc uccuccucac ccacaaggac     1320

ugccccauca ccgccaugca gaaggagucc cagggcuacc ucucccccga guccuccccc     1380

cccgccuccc ccguccccgc cugcucccag cagcagguca uccagcacaa caccaucacc     1440

accuccuccu ccgucuccga ggucgucggc uccuccaccc ucucccagcu caccacccac     1500

cgcaccgacc ucaaccccau ccucuga                                         1527


<210>  8175
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CREB5__Homo_sapiens__CCDS5417.1

<400>  8175
augaucuacg aggaaagcaa gaugaaccug gagcaggaaa gacccuucgu gugcuccgcc       60

ccuggcuguu cucaaagguu uccaaccgag gaccaccuca ugauucaucg gcacaaacau      120

gaaaugacac uuaaguuccc gucaauaaaa acugauaaua ugcugaguga ccagacgccc      180

accccuacac gcuuuuugaa gaacugcgag gaggucgggu uauucagcga acuggauugu      240

ucccuagagc acgaauuucg aaaagcucag gaggaggaau cuucgaagcg uaauaucuca      300

augcauaacg caguuggagg ugccaugacu ggcccaggga cccaccagcu cagcagugcg      360

agacugccca aucacgacac aaacguggua auucaacagg cuaugccuuc cccacagucu      420

agcuccguga ucacccaggc ccccucaacu aauaggcaaa uuggaccugu cccaggcagu      480

cuuagcucuc uguugcaucu ccacaaccgg cagcgccagc cgaugcccgc auccaugccu      540

gguacacugc caaaucccac caugccuggg ucaagcgccg ugcugaugcc aauggagaga      600

cagaugagug uuaacucuuc caucauggga augcaaggcc ccaaucucag caacccgugc      660

gcuucgccuc aggugcagcc caugcauucu gaagcaaaga ugagguuaaa agccgcucug      720

acgcaccacc cagccgcgau guccaauggc aacaugaaua cuauggggca uaugauggag      780

augaugggau cacggcaaga ucagaccccu caccaucaca ugcauaguca cccccaccag      840

caucagacac uuccacccca ccauccuuau ccacaccaac accagcaucc ggcacaccau      900

ccccacccuc agccacauca ccagcaaaac cacccccauc accauagcca cucccauuug      960

cacgcccacc cugcucauca ccagacuucu ccacaucccc cgcugcacac cgguaaccag     1020

gcccagguca gcccugcaac acaacagaug cagccaaccc agacgauaca acccccucag     1080

cccacuggcg ggcgccgaag aaggguggua gacgaagauc cagacgagcg gcgucgcaag     1140

uuccuagaga gaaauagggc ugccgcgaca cggugucgac agaaacgcaa gguuugggug     1200

augucacucg agaaaaaggc cgaagaacug acccaaacua acaugcagcu ucagaaugag     1260

gucaguaugc ugaagaacga aguggcacag uugaaacaac uccuguuaac acacaaggau     1320

ugcccuauca ccgcuaugca gaaagagucc cagggauacc ugagccccga gucuucacca     1380

ccggccaguc cugugcccgc uuguagccag caacagguca uucagcauaa uacgaucacc     1440

acauccucuu cgguuagcga agugguaggc uccucaacuc ucagucagcu uaccacacac     1500

agaacugacc ugaacccaau uuuguga                                         1527


<210>  8176
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CREB5__Homo_sapiens__CCDS5417.1

<400>  8176
augaucuacg aggagagcaa gaugaaccug gagcaggaga gacccuucgu gugcagcgcc       60

cccggcugca gccagagauu ccccaccgag gaccaccuga ugauccacag acacaagcac      120

gagaugaccc ugaaguuccc cagcaucaag accgacaaca ugcugagcga ccagaccccc      180

acccccacca gauuccugaa gaacugcgag gaggugggcc uguucagcga gcuggacugc      240

agccuggagc acgaguucag aaaggcccag gaggaggaga gcagcaagag aaacaucagc      300

augcacaacg ccgugggcgg cgccaugacc ggccccggca cccaccagcu gagcagcgcc      360

agacugccca accacgacac caacguggug auccagcagg ccaugcccag cccccagagc      420

agcagcguga ucacccaggc ccccagcacc aacagacaga ucggccccgu gcccggcagc      480

cugagcagcc ugcugcaccu gcacaacaga cagagacagc ccaugcccgc cagcaugccc      540

ggcacccugc ccaaccccac caugcccggc agcagcgccg ugcugaugcc cauggagaga      600

cagaugagcg ugaacagcag caucaugggc augcagggcc ccaaccugag caaccccugc      660

gccagccccc aggugcagcc caugcacagc gaggccaaga ugagacugaa ggccgcccug      720

acccaccacc ccgccgccau gagcaacggc aacaugaaca ccaugggcca caugauggag      780

augaugggca gcagacagga ccagaccccc caccaccaca ugcacagcca cccccaccag      840

caccagaccc ugccccccca ccaccccuac ccccaccagc accagcaccc cgcccaccac      900

ccccaccccc agccccacca ccagcagaac cacccccacc accacagcca cagccaccug      960

cacgcccacc ccgcccacca ccagaccagc ccccaccccc cccugcacac cggcaaccag     1020

gcccagguga gccccgccac ccagcagaug cagcccaccc agaccaucca gcccccccag     1080

cccaccggcg gcagaagaag aagaguggug gacgaggacc ccgacgagag aagaagaaag     1140

uuccuggaga gaaacagagc cgccgccacc agaugcagac agaagagaaa ggugugggug     1200

augagccugg agaagaaggc cgaggagcug acccagacca acaugcagcu gcagaacgag     1260

gugagcaugc ugaagaacga gguggcccag cugaagcagc ugcugcugac ccacaaggac     1320

ugccccauca ccgccaugca gaaggagagc cagggcuacc ugagccccga gagcagcccc     1380

cccgccagcc ccgugcccgc cugcagccag cagcagguga uccagcacaa caccaucacc     1440

accagcagca gcgugagcga gguggugggc agcagcaccc ugagccagcu gaccacccac     1500

agaaccgacc ugaaccccau ccuguga                                         1527


<210>  8177
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CREB5__Homo_sapiens__CCDS5417.1

<400>  8177
augaucuacg aggaaagcaa gaugaaccug gagcaggaaa gacccuucgu gugcuccgcc       60

ccuggcuguu cucaacgguu uccgaccgag gaccaccuca ugauucaucg ccacaaacau      120

gaaaugacac ugaaguuccc cagcaucaaa acggauaaua ugcuuuccga ccagaccccu      180

acacccacca gauuucugaa gaacugcgag gaggucggac ucuucucuga acuggauugu      240

agccuugagc acgaauuucg gaaagcucag gaggaggaau ccucuaagcg caauauuagc      300

augcauaacg ccguuggggg cgcgaugaca gggccuggaa cccaccagcu guccagcgcu      360

agacucccca aucacgacac aaacguggug auccaacagg ccaugccuuc uccgcagucc      420

agcucuguca uuacccaggc ccccuccacg aaucggcaaa ucggcccugu gcccgggagc      480

cugucuuccc ugcuccaucu gcacaaccgc cagagacagc cuaugcccgc uagcaugccg      540

ggaacccuuc cuaaucccac aaugccuggc uccucugccg uucugaugcc cauggagcgg      600

cagaugagcg ugaacuccag caucaugggc augcaagggc ccaaucucuc uaacccuugc      660

gcuuccccgc agguccagcc caugcauagc gaagccaaga ugcgccugaa agcggcccuu      720

acccaccacc cugcugccau gucuaaugga aacaugaaua caaugggcca uaugauggag      780

augaugggga gcagacaaga ucagacgccc caccaucaca ugcauuccca cccucaccag      840

caucagaccc ugcccccgca ccauccuuau ccccaccaac accagcaucc ugcucaccau      900

ccccacccuc agccccauca ccagcaaaac cacccgcauc accauucuca cagccaucuc      960

cacgcccacc cugcgcauca ccagacaagc ccccaucccc cucugcacac cggaaaccag     1020

gcccaggugu ccccggcuac acaacagaug cagcccaccc agaccauuca accuccccag     1080

ccuacaggcg ggcggcgcag acggguugug gacgaagauc ccgacgagcg cagacggaag     1140

uuccuggaga gaaaucgcgc cgcugccacg cgguguagac agaaacgcaa ggucugggug     1200

augucucucg agaaaaaggc cgaagaacug acccaaacaa acaugcagcu ucagaaugag     1260

guguccaugc ugaagaacga agucgcucag cucaaacaac ugcuucugac ccacaaggau     1320

ugcccuauca cagcgaugca gaaagagagc cagggauacc ucucucccga guccagcccg     1380

ccugccuccc ccguuccugc uuguucucag caacagguga uucagcauaa uaccaucacg     1440

acaagcuccu cugugagcga agucgugggc uccagcaccc ugucucagcu gaccacacac     1500

cggaccgacc ucaaccccau ucuguga                                         1527


<210>  8178
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CRTC2__Homo_sapiens__Q53ET0

<400>  8178

Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             


<210>  8179
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  CRTC2__Homo_sapiens__CCDS30875.1

<400>  8179
auggcgacgu cgggggcgaa cgggccuggu ucggccacgg ccucggcuuc caauccgcgc       60

aaauuuagug agaagauugc gcugcagaag cagcgucagg ccgaggagac ggcggccuuc      120

gaggagguga ugauggacau cggcuccacc cgguuacagg cccaaaaacu gcgacuggca      180

uacacaagga gcucucauua uggugggucu cugcccaaug uuaaccagau uggcucuggc      240

cuggccgagu uccagagccc ccuccacuca ccuuuggauu caucucggag cacucggcac      300

caugggcugg uggaacgggu gcagcgagau ccucgaagaa uggugucccc acuucgccga      360

uacacccgcc acauugacag cucucccuau aguccugccu acuuaucucc ucccccagag      420

ucuagcuggc gaaggacgau ggccuggggc aauuucccug cagagaaggg gcaguuguuu      480

cgacuaccau cugcacuuaa caggacaagc ucugacucug cccuucauac aagugugaug      540

aaccccaguc cccaggauac cuacccaggc cccacaccuc ccagcauccu gcccagccga      600

cgugggggua uucuggaugg ugaaauggac cccaaaguac cugcuauuga ggagaacuug      660

cuagaugaca agcauuugcu gaagccaugg gaugcuaaga agcuauccuc auccucuucc      720

cgaccucggu ccugugaagu cccuggaauu aacaucuuuc caucuccuga ccagccugcc      780

aaugugccug uccucccacc ugccaugaac acggggggcu cccuaccuga ccucaccaac      840

cugcacuuuc ccccaccacu gcccaccccc cuggacccug aagagacagc cuacccuagc      900

cugagugggg gcaacaguac cuccaauuug acccacacca ugacucaccu gggcaucagc      960

aggggcaugg gccugggccc aggcuaugau gcaccaggac uucauucacc ucucagccac     1020

ccaucccugc aguccucccu aagcaauccc aaccuccagg cuucccugag caguccucag     1080

ccccagcuuc agggcuccca cagccacccc ucucugccug ccuccuccuu ggcccgccau     1140

guacugccca ccaccucccu gggccacccc ucacucagug cuccggcucu cuccuccucc     1200

ucuuccuccu ccuccacuuc aucuccuguu uugggcgccc ccucuuaccc ugcuucuacc     1260

ccuggggccu ccccccacca ccgccgugug ccccucagcc cccugaguuu gcucgcgggc     1320

ccagccgacg ccagaagguc ccaacagcag cugcccaaac aguuuucgcc aacaauguca     1380

cccaccuugu cuuccaucac ucagggcguc ccccuggaua ccaguaaacu guccacugac     1440

cagcgguuac ccccauaccc auacagcucc ccaagucugg uucugccuac ccagccccac     1500

accccaaagu cucuacagca gccagggcug cccucucagu cuuguucagu gcaguccuca     1560

ggugggcagc ccccaggcag gcagucucau uaugggacac cguacccacc ugggcccagu     1620

gggcaugggc aacagucuua ccaccggcca augagugacu ucaaccuggg gaaucuggag     1680

caguucagca uggagagccc aucagccagc cuggugcugg aucccccugg cuuuucugaa     1740

gggccuggau uuuuaggggg ugaggggcca auggguggcc cccaggaucc ccacaccuuc     1800

aaccaccaga acuugaccca cuguucccgc cauggcucag ggccuaacau cauccucaca     1860

ggggacuccu cuccagguuu cucuaaggag auugcagcag cccuggccgg agugccuggc     1920

uuugaggugu cagcagcugg auuggagcua gggcuugggc uagaagauga gcugcgcaug     1980

gagccacugg gccuggaagg gcuaaacaug cugagugacc ccugugcccu gcugccugau     2040

ccugcugugg aggagucauu ccgcagugac cggcuccaau ga                        2082


<210>  8180
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       CRTC2__Homo_sapiens__CCDS30875.1

<400>  8180
auggccacca gcggcgccaa cgggcccggc uccgcgaccg ccagcgccuc caacccgcgc       60

aaguucagcg agaagaucgc ccugcagaag cagcggcagg ccgaggagac ggcggccuuc      120

gaggagguga ugauggacau cggguccacc cgccuccagg cccagaagcu gcggcuggcc      180

uacacccgca gcucccacua cggcgggagc cuccccaacg ucaaccagau cggcuccggc      240

cuggcggagu uccagagccc ccugcacagc ccccucgacu ccucccggag cacccgccac      300

cacgggcugg uggagcgggu gcagcgcgac ccgcggcgca uggucagccc ccugcggcgc      360

uacacgcggc acaucgacuc cucccccuac agccccgccu accucucccc gccgcccgag      420

agcagcuggc gccggaccau ggccuggggc aacuuccccg ccgagaaggg gcagcuguuc      480

cgccugcccu ccgcccucaa ccggaccagc uccgacagcg cgcugcacac cuccgugaug      540

aaccccagcc cccaggacac guaccccggc ccgaccccgc ccuccauccu gcccagccgc      600

cgcgggggca uccucgacgg cgagauggac cccaaggugc ccgccaucga ggagaaccug      660

cuggacgaca agcaccuccu gaagcccugg gacgccaaga agcuguccag cuccagcucc      720

cggccccgga gcugcgaggu cccggggauc aacaucuucc ccucccccga ccagcccgcc      780

aacgugccgg ugcucccgcc cgccaugaac accggcggga gccugcccga ccugaccaac      840

cuccacuucc cgccgccccu gcccacgccc cuggaccccg aggagaccgc guaccccucc      900

cucagcggcg gcaacuccac cagcaaccug acccacacga ugacccaccu ggggaucagc      960

cgcggcaugg ggcucggccc cggguacgac gcccccggcc ugcacagccc ccugucccac     1020

cccucccucc agagcucccu gagcaacccg aaccugcagg ccucccucag cagcccccag     1080

ccccagcugc agggcuccca cucccacccc agccugccgg ccuccagccu cgcccgccac     1140

guccugccca ccaccucccu ggggcacccc agccucuccg cgcccgcccu gagcagcucc     1200

agcuccagcu ccagcacguc cagcccggug cugggcgccc ccuccuaccc cgccagcacc     1260

cccggggccu ccccgcacca ccggcgcgug ccccucagcc cccugucccu gcucgcgggc     1320

ccggccgacg cccggcgcag ccagcagcag cugcccaagc aguucucccc caccaugagc     1380

cccacccugu ccagcaucac gcaggggguc ccgcuggaca ccuccaagcu cagcaccgac     1440

cagcggcugc cgcccuaccc cuacagcucc cccagccugg ugcuccccac ccagccccac     1500

acgcccaagu cccugcagca gccgggccug cccagccagu ccugcagcgu gcaguccagc     1560

ggcgggcagc cgcccggccg ccagucccac uacgggaccc ccuacccgcc cggccccagc     1620

gggcacggcc agcaguccua ccaccggccc augagcgacu ucaaccucgg caaccuggag     1680

caguucucca uggagagccc cuccgccagc cugguccucg acccgcccgg guucuccgag     1740

ggccccgggu uccugggcgg cgaggggccc augggcgggc cccaggaccc ccacaccuuc     1800

aaccaccaga accugaccca cugcagccgc cacggcuccg ggccgaacau cauccucacg     1860

ggcgacagca gccccggcuu cuccaaggag aucgcggccg cccuggccgg ggugcccggc     1920

uucgagguga gcgccgcggg gcuggagcuc ggccuggggc uggaggacga gcuccggaug     1980

gagccgcugg gccuggaggg ccucaacaug cuguccgacc ccugcgcccu gcuccccgac     2040

cccgccgucg aggagagcuu ccgcuccgac cggcugcagu ga                        2082


<210>  8181
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       CRTC2__Homo_sapiens__CCDS30875.1

<400>  8181
auggccaccu ccggcgccaa cggccccggc uccgccaccg ccuccgccuc caacccccgc       60

aaguucuccg agaagaucgc ccuccagaag cagcgccagg ccgaggagac cgccgccuuc      120

gaggagguca ugauggacau cggcuccacc cgccuccagg cccagaagcu ccgccucgcc      180

uacacccgcu ccucccacua cggcggcucc cuccccaacg ucaaccagau cggcuccggc      240

cucgccgagu uccagucccc ccuccacucc ccccucgacu ccucccgcuc cacccgccac      300

cacggccucg ucgagcgcgu ccagcgcgac ccccgccgca uggucucccc ccuccgccgc      360

uacacccgcc acaucgacuc cucccccuac ucccccgccu accucucccc cccccccgag      420

uccuccuggc gccgcaccau ggccuggggc aacuuccccg ccgagaaggg ccagcucuuc      480

cgccuccccu ccgcccucaa ccgcaccucc uccgacuccg cccuccacac cuccgucaug      540

aaccccuccc cccaggacac cuaccccggc cccacccccc ccuccauccu ccccucccgc      600

cgcggcggca uccucgacgg cgagauggac cccaaggucc ccgccaucga ggagaaccuc      660

cucgacgaca agcaccuccu caagcccugg gacgccaaga agcucuccuc cuccuccucc      720

cgcccccgcu ccugcgaggu ccccggcauc aacaucuucc ccucccccga ccagcccgcc      780

aacguccccg uccucccccc cgccaugaac accggcggcu cccuccccga ccucaccaac      840

cuccacuucc cccccccccu ccccaccccc cucgaccccg aggagaccgc cuaccccucc      900

cucuccggcg gcaacuccac cuccaaccuc acccacacca ugacccaccu cggcaucucc      960

cgcggcaugg gccucggccc cggcuacgac gcccccggcc uccacucccc ccucucccac     1020

cccucccucc aguccucccu cuccaacccc aaccuccagg ccucccucuc cuccccccag     1080

ccccagcucc agggcuccca cucccacccc ucccuccccg ccuccucccu cgcccgccac     1140

guccucccca ccaccucccu cggccacccc ucccucuccg cccccgcccu cuccuccucc     1200

uccuccuccu ccuccaccuc cucccccguc cucggcgccc ccuccuaccc cgccuccacc     1260

cccggcgccu ccccccacca ccgccgcguc ccccucuccc cccucucccu ccucgccggc     1320

cccgccgacg cccgccgcuc ccagcagcag cuccccaagc aguucucccc caccaugucc     1380

cccacccucu ccuccaucac ccagggcguc ccccucgaca ccuccaagcu cuccaccgac     1440

cagcgccucc cccccuaccc cuacuccucc cccucccucg uccuccccac ccagccccac     1500

acccccaagu cccuccagca gcccggccuc cccucccagu ccugcuccgu ccaguccucc     1560

ggcggccagc cccccggccg ccagucccac uacggcaccc ccuacccccc cggccccucc     1620

ggccacggcc agcaguccua ccaccgcccc auguccgacu ucaaccucgg caaccucgag     1680

caguucucca uggagucccc cuccgccucc cucguccucg acccccccgg cuucuccgag     1740

ggccccggcu uccucggcgg cgagggcccc augggcggcc cccaggaccc ccacaccuuc     1800

aaccaccaga accucaccca cugcucccgc cacggcuccg gccccaacau cauccucacc     1860

ggcgacuccu cccccggcuu cuccaaggag aucgccgccg cccucgccgg cguccccggc     1920

uucgaggucu ccgccgccgg ccucgagcuc ggccucggcc ucgaggacga gcuccgcaug     1980

gagccccucg gccucgaggg ccucaacaug cucuccgacc ccugcgcccu ccuccccgac     2040

cccgccgucg aggaguccuu ccgcuccgac cgccuccagu ga                        2082


<210>  8182
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       CRTC2__Homo_sapiens__CCDS30875.1

<400>  8182
auggccacca gcggcgcuaa cgggcccgga uccgcaacag ccucugcguc aaauccuaga       60

aaguucagug agaaaaucgc ucugcagaag caaaggcagg ccgaagagac ugcagccuuu      120

gaagagguga ugauggacau ugguagcacg cggcuccagg cucagaaacu ucgccuggca      180

uacacccgau ccucucacua uggcgggucg uugccaaacg ucaaucaaau aggaucaggc      240

uuagccgagu uccagagccc gcugcauagu ccccuagauu ccucucguag cacaagacac      300

cauggucucg uugaaagggu gcagcgggac ccucgcagaa ugguaucccc acugaggcgg      360

uacacucgcc acaucgauuc aagucccuau agcccugcuu accuuucucc acccccugag      420

uccucauggc gaagaaccau ggccuggggg aacuuuccag cggaaaaggg acagcuguuc      480

agguugccga gcgcacucaa ucggacaagu ucugacuccg cccugcauac cagcgugaug      540

aaccccucgc cucaagauac uuauccaggc cccacaccuc caucuauucu gcccucccgu      600

cgcggcggga uccucgacgg agagauggau ccgaaagucc cugcuauuga agagaauuua      660

cuggacgaua agcaccuuuu gaagcccugg gacgccaaaa agcugucaag uagcuccucu      720

agaccaagga gcugcgaggu gccugguauc aacauauuuc ccucaccaga ucagcccgca      780

aauguuccug ugcuaccacc ggcuaugaac accggcggga gucuccccga ccugacgaau      840

cuucacuucc cuccaccccu gccuacucca uuggaucccg aagagaccgc cuacccgucc      900

cucagcggag gcaacucuac aucaaaucug acucauacca ugacacacuu agguaucagu      960

cgggggaugg gacugggccc uggcuaugac gcgccagggc uccauagccc ccuuucccac     1020

ccuucucugc agucgagcuu guccaacccc aaucuacagg ccucacugag uucuccacaa     1080

ccucagcucc agggaagcca cucccauccc ucacugccag caagcucucu ugcucgacac     1140

guccugccga ccacguccuu gggucauccu agucucagcg cccccgcucu gucuuccuca     1200

aguagcucgu ccucuacuag cucaccagug uuaggcgccc ccaguuaccc ugcauccaca     1260

ccaggggccu cuccccacca ucgcagagua ccucugagcc cgcuaucccu ccuggcugga     1320

ccagcggacg caaggcgguc acaacagcag cuucccaaac aguuuagccc uaccaugagu     1380

ccaacuuugu cuuccauuac acaaggcguu ccccuggaua ccagcaagcu cucgacggac     1440

cagcgccugc cuccguaccc cuauucaucu ccaagucuug ugcugccuac ccagccccac     1500

acaccaaaau ccuugcagca accuggucuc cccagccagu cuuguagcgu ccaguccuca     1560

gggggccagc caccgggaag acaaagucac uacggcacuc cuuauccccc agggcccagc     1620

ggacaugguc agcagucuua ccacaggccu auguccgauu ucaaccuggg caacuuagaa     1680

caguuuucaa uggagagucc aagcgccucc cuggugcuag aucccccugg guucucugaa     1740

ggaccgggcu uucucggugg ggagggccca augggaggcc cccaagaccc ucauaccuuc     1800

aaucaccaga accugacaca cugcucgcgu caugggagcg gacccaauau cauucuuacu     1860

ggugacucau ccccaggcuu uaguaaggag aucgcugccg cauuggccgg ggugccugga     1920

uucgaagucu cugcugccgg ccuggagcuc ggucuggggu uagaagauga gcugcggaug     1980

gaaccccuug gcuuggaggg acucaacaug cugagcgacc caugugcacu acugccugau     2040

ccggcgguug aggaauccuu ccgaucagac agacuccagu ga                        2082


<210>  8183
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       CRTC2__Homo_sapiens__CCDS30875.1

<400>  8183
auggccacca gcggcgccaa cggccccggc agcgccaccg ccagcgccag caaccccaga       60

aaguucagcg agaagaucgc ccugcagaag cagagacagg ccgaggagac cgccgccuuc      120

gaggagguga ugauggacau cggcagcacc agacugcagg cccagaagcu gagacuggcc      180

uacaccagaa gcagccacua cggcggcagc cugcccaacg ugaaccagau cggcagcggc      240

cuggccgagu uccagagccc ccugcacagc ccccuggaca gcagcagaag caccagacac      300

cacggccugg uggagagagu gcagagagac cccagaagaa uggugagccc ccugagaaga      360

uacaccagac acaucgacag cagccccuac agccccgccu accugagccc cccccccgag      420

agcagcugga gaagaaccau ggccuggggc aacuuccccg ccgagaaggg ccagcuguuc      480

agacugccca gcgcccugaa cagaaccagc agcgacagcg cccugcacac cagcgugaug      540

aaccccagcc cccaggacac cuaccccggc cccacccccc ccagcauccu gcccagcaga      600

agaggcggca uccuggacgg cgagauggac cccaaggugc ccgccaucga ggagaaccug      660

cuggacgaca agcaccugcu gaagcccugg gacgccaaga agcugagcag cagcagcagc      720

agacccagaa gcugcgaggu gcccggcauc aacaucuucc ccagccccga ccagcccgcc      780

aacgugcccg ugcugccccc cgccaugaac accggcggca gccugcccga ccugaccaac      840

cugcacuucc cccccccccu gcccaccccc cuggaccccg aggagaccgc cuaccccagc      900

cugagcggcg gcaacagcac cagcaaccug acccacacca ugacccaccu gggcaucagc      960

agaggcaugg gccugggccc cggcuacgac gcccccggcc ugcacagccc ccugagccac     1020

cccagccugc agagcagccu gagcaacccc aaccugcagg ccagccugag cagcccccag     1080

ccccagcugc agggcagcca cagccacccc agccugcccg ccagcagccu ggccagacac     1140

gugcugccca ccaccagccu gggccacccc agccugagcg cccccgcccu gagcagcagc     1200

agcagcagca gcagcaccag cagccccgug cugggcgccc ccagcuaccc cgccagcacc     1260

cccggcgcca gcccccacca cagaagagug ccccugagcc cccugagccu gcuggccggc     1320

cccgccgacg ccagaagaag ccagcagcag cugcccaagc aguucagccc caccaugagc     1380

cccacccuga gcagcaucac ccagggcgug ccccuggaca ccagcaagcu gagcaccgac     1440

cagagacugc cccccuaccc cuacagcagc cccagccugg ugcugcccac ccagccccac     1500

acccccaaga gccugcagca gcccggccug cccagccaga gcugcagcgu gcagagcagc     1560

ggcggccagc cccccggcag acagagccac uacggcaccc ccuacccccc cggccccagc     1620

ggccacggcc agcagagcua ccacagaccc augagcgacu ucaaccuggg caaccuggag     1680

caguucagca uggagagccc cagcgccagc cuggugcugg acccccccgg cuucagcgag     1740

ggccccggcu uccugggcgg cgagggcccc augggcggcc cccaggaccc ccacaccuuc     1800

aaccaccaga accugaccca cugcagcaga cacggcagcg gccccaacau cauccugacc     1860

ggcgacagca gccccggcuu cagcaaggag aucgccgccg cccuggccgg cgugcccggc     1920

uucgagguga gcgccgccgg ccuggagcug ggccugggcc uggaggacga gcugagaaug     1980

gagccccugg gccuggaggg ccugaacaug cugagcgacc ccugcgcccu gcugcccgac     2040

cccgccgugg aggagagcuu cagaagcgac agacugcagu ga                        2082


<210>  8184
<211>  2082
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       CRTC2__Homo_sapiens__CCDS30875.1

<400>  8184
auggccacca gcggcgcuaa cgggcccgga uccgccacag cgucugcuag caauccuaga       60

aaguucuccg agaaaaucgc ccugcagaag caacggcagg ccgaagagac ggcugccuuu      120

gaagagguga ugauggacau uggcucuacc cgccuccagg cucagaaacu gagacuugcc      180

uacacacgga gcucccacua ugggggaucu cugccgaacg ucaaucaaau cggcagcggg      240

cucgcggagu uccagagccc ccugcauucc ccucuugauu cuucccgcag caccagacac      300

cauggacugg uugaacgggu gcagcgcgac cccagacgga uggugucucc ucuccgcaga      360

uacacacggc acauugauuc cagccccuau ucuccugccu accugucccc gcccccugag      420

agcuccuggc gcagaaccau ggcuuggggc aacuuucccg ccgaaaaggg ccagcuguuc      480

cggcucccuu cugcucugaa ucgcacaagc uccgacagcg cccuucauac cucugucaug      540

aaccccuccc cgcaagauac guauccuggg cccaccccuc ccagcauccu gcccucuaga      600

cggggaggca uucucgacgg ggagauggau ccuaaagugc cggcgaucga agagaaucug      660

cuugacgaua agcaucugcu caagcccugg gacgccaaaa agcugagcuc cucuagcucc      720

agaccucgca gcugcgaggu ucccggaauc aacauuuuuc cuucucccga ucagccggcu      780

aaugugccug uccugccccc ugccaugaac acaggcgggu cccuccccga ccugaccaau      840

cuucacuucc cucccccgcu gccuacaccc cucgaucccg aagagaccgc uuacccuagc      900

cugucuggag gcaacuccac gagcaaucuu acacacacca ugacacaccu gggcaucucc      960

cgggggaugg gacucggccc gggguaugac gcccccggac ugcauucucc ucugagccac     1020

cccucccucc agucuagccu guccaacccu aaucuucagg ccagccuguc uagcccccaa     1080

ccucagcucc agggcuccca cucucauccc ucccugccgg cuagcucucu ugcgagacac     1140

gugcugccua ccaccagccu cgggcauccc ucccugagcg ccccugcucu gucuuccagc     1200

uccucuagcu ccucuacaag cucccccguu cucggagccc cgucuuaccc ugccagcacg     1260

cccggcgcuu ccccucacca ucgccgggug ccccugagcc cccuuucucu gcucgccggc     1320

ccugcggacg cuagacgcuc ccaacagcag cugccgaaac aguuuagccc caccaugucu     1380

ccuacacugu ccagcauuac ccaagggguc ccccuugaua caucuaagcu cuccaccgac     1440

cagcggcugc cucccuaccc uuauagcucc ccgagccugg ugcuccccac gcagccucac     1500

acacccaaau cucugcagca accuggacuu cccagccagu ccuguucugu gcagagcucc     1560

ggcgggcagc cgccuggaag acaaucucac uacggcaccc ccuauccccc ugggcccagc     1620

ggccauggac agcaguccua ccaccgcccu augucugauu ucaaccuggg caaccucgaa     1680

caguuuagca uggagucccc gagcgccucu cugguccugg aucccccugg guucuccgaa     1740

ggacccggcu uucuuggggg agagggcccu augggcgggc cccaagaccc gcauaccuuc     1800

aaucaccaga accucacaca cugcagccgg cauggaucug gcccuaauau cauucugacc     1860

ggggacucca gccccggauu uuccaaggag aucgccgcug cccuggcugg cguuccuggg     1920

uucgaagugu cugccgcggg acucgagcug ggccuugggc uggaagauga gcucagaaug     1980

gaaccccugg gccuggaggg acuuaacaug cucagcgacc cuugugcccu gcugcccgau     2040

ccggcugugg aggaauccuu ccgcagcgac cggcuccagu ga                        2082


<210>  8185
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJB11__Homo_sapiens__Q9UBS4

<400>  8185

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210>  8186
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJB11__Homo_sapiens__AAF61711

<400>  8186
auggcuccgc agaaccugag caccuuuugc cuguugcugc uauaccucau cggggcggug       60

auugccggac gagauuucua uaagaucuug ggggugccuc gaagugccuc uauaaaggau      120

auuaaaaagg ccuauaggaa acuagcccug cagcuucauc ccgaccggaa cccugaugau      180

ccacaagccc aggagaaauu ccaggaucug ggugcugcuu augagguucu gucagauagu      240

gagaaacgga aacaguacga uacuuauggu gaagaaggau uaaaagaugg ucaucagagc      300

ucccauggag acauuuuuuc acacuucuuu ggggauuuug guuucauguu uggaggaacc      360

ccucgucagc aagacagaaa uauuccaaga ggaagugaua uuauuguaga ucuagaaguc      420

acuuuggaag aaguauaugc aggaaauuuu guggaaguag uuagaaacaa accuguggca      480

aggcaggcuc cuggcaaacg gaagugcaau ugucggcaag agaugcggac cacccagcug      540

ggcccugggc gcuuccaaau gacccaggag guggucugcg acgaaugccc uaaugucaaa      600

cuagugaaug aagaacgaac gcuggaagua gaaauagagc cuggggugag agacggcaug      660

gaguaccccu uuauuggaga aggugagccu cacguggaug gggagccugg agauuuacgg      720

uuccgaauca aaguugucaa gcacccaaua uuugaaagga gaggagauga uuuguacaca      780

aaugugacaa ucucauuagu ugagucacug guuggcuuug agauggauau uacucacuug      840

gauggucaca agguacauau uucccgggau aagaucacca ggccaggagc gaagcuaugg      900

aagaaagggg aagggcuccc caacuuugac aacaacaaua ucaagggcuc uuugauaauc      960

acuuuugaug uggauuuucc aaaagaacag uuaacagagg aagcgagaga agguaucaaa     1020

cagcuacuga aacaaggguc agugcagaag guauacaaug gacugcaagg auauuga        1077


<210>  8187
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJB11__Homo_sapiens__AAF61711

<400>  8187
auggcgcccc agaaccugag caccuucugc cuccugcugc ucuaccugau cggcgccgug       60

aucgccgggc gcgacuucua caagauccug ggcgucccgc gguccgccag caucaaggac      120

aucaagaagg ccuaccgcaa gcucgcccug cagcugcacc ccgaccggaa ccccgacgac      180

ccccaggccc aggagaaguu ccaggaccuc ggggcggccu acgaggugcu guccgacagc      240

gagaagcgca agcaguacga caccuacggc gaggaggggc ugaaggacgg ccaccagucc      300

agccacggcg acaucuucuc ccacuucuuc ggggacuucg gcuucauguu cgggggcacg      360

ccgcggcagc aggaccgcaa caucccccgg gggagcgaca ucaucgugga ccucgagguc      420

acccuggagg agguguacgc cggcaacuuc guggaggucg ugcgcaacaa gcccguggcc      480

cggcaggcgc ccggcaagcg caagugcaac ugccggcagg agaugcgcac cacccagcug      540

gggccgggcc gguuccagau gacgcaggag gucgugugcg acgagugccc caacgugaag      600

cucgucaacg aggagcgcac ccuggaggug gagaucgagc ccggggugcg ggacggcaug      660

gaguaccccu ucaucggcga gggggagccg cacgucgacg gcgagcccgg ggaccugcgc      720

uuccggauca agguggugaa gcaccccauc uucgagcgcc ggggcgacga ccucuacacc      780

aacgucacca ucucccuggu ggagagccug gugggguucg agauggacau cacgcaccuc      840

gacggccaca agguccacau cucccgcgac aagaucaccc ggcccggcgc caagcugugg      900

aagaaggggg agggccugcc gaacuucgac aacaacaaca ucaaggggag ccucaucauc      960

accuucgacg uggacuuccc caaggagcag cugaccgagg aggcccgcga gggcaucaag     1020

cagcugcuca agcagggguc cgugcagaag gucuacaacg gccugcaggg cuacuga        1077


<210>  8188
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJB11__Homo_sapiens__AAF61711

<400>  8188
auggcccccc agaaccucuc caccuucugc cuccuccucc ucuaccucau cggcgccguc       60

aucgccggcc gcgacuucua caagauccuc ggcguccccc gcuccgccuc caucaaggac      120

aucaagaagg ccuaccgcaa gcucgcccuc cagcuccacc ccgaccgcaa ccccgacgac      180

ccccaggccc aggagaaguu ccaggaccuc ggcgccgccu acgagguccu cuccgacucc      240

gagaagcgca agcaguacga caccuacggc gaggagggcc ucaaggacgg ccaccagucc      300

ucccacggcg acaucuucuc ccacuucuuc ggcgacuucg gcuucauguu cggcggcacc      360

ccccgccagc aggaccgcaa caucccccgc ggcuccgaca ucaucgucga ccucgagguc      420

acccucgagg aggucuacgc cggcaacuuc gucgaggucg uccgcaacaa gcccgucgcc      480

cgccaggccc ccggcaagcg caagugcaac ugccgccagg agaugcgcac cacccagcuc      540

ggccccggcc gcuuccagau gacccaggag gucgucugcg acgagugccc caacgucaag      600

cucgucaacg aggagcgcac ccucgagguc gagaucgagc ccggcguccg cgacggcaug      660

gaguaccccu ucaucggcga gggcgagccc cacgucgacg gcgagcccgg cgaccuccgc      720

uuccgcauca aggucgucaa gcaccccauc uucgagcgcc gcggcgacga ccucuacacc      780

aacgucacca ucucccucgu cgagucccuc gucggcuucg agauggacau cacccaccuc      840

gacggccaca agguccacau cucccgcgac aagaucaccc gccccggcgc caagcucugg      900

aagaagggcg agggccuccc caacuucgac aacaacaaca ucaagggcuc ccucaucauc      960

accuucgacg ucgacuuccc caaggagcag cucaccgagg aggcccgcga gggcaucaag     1020

cagcuccuca agcagggcuc cguccagaag gucuacaacg gccuccaggg cuacuga        1077


<210>  8189
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJB11__Homo_sapiens__AAF61711

<400>  8189
auggcucccc agaaccugag caccuucugc cuccuucugu uguacuuaau cggcgccgug       60

auugcaggga gagacuuuua uaagauacug ggagucccua gguccgccuc uaucaaagau      120

auuaagaaag cguaccggaa gcuagcucuc caacugcacc cagaccgcaa uccggaugac      180

ccccaggccc aggagaaauu ccaggaucuu ggugcagccu augaaguucu gucagacagu      240

gagaagcgaa agcaauacga uacauauggc gaagaggggu ugaaagacgg acaucagagc      300

ucccacggcg auaucuuuuc ucauuucuuu ggugacuucg gguuuauguu cggaggcacu      360

ccucgucagc aggauagaaa cauuccaagg ggcucggaca ucauagugga ucucgaagua      420

acgcuggagg agguguacgc ugggaauuuu gucgaagugg uucggaacaa gcccguggca      480

cgccaagccc cuggaaaaag aaaguguaau ugcaggcagg agaugcggac cacacagcug      540

gguccaggcc gcuuccagau gacucaagaa gucgugugug acgagugccc caacguaaaa      600

cucguuaaug aggaacgaac cuuagaggug gaaaucgagc cuggggucag agacggaaug      660

gaauauccau uuauuggcga gggugagccg cacguggaug gggaacccgg agaccugagg      720

uuccggauca agguggucaa gcauccuauu uuugagcguc gcggcgauga ccuuuacaca      780

aacguuacca ucucauuggu ggaaagccug guaggcuucg agauggauau aacucaccua      840

gacgggcaca aagugcauau uaguagagau aagaucacaa ggccaggagc uaaacucugg      900

aagaaaggug aaggccugcc caauuucgac aacaauaaca uuaagggguc ccuuaucauc      960

accuuugaug ucgacuuccc uaaagagcag cugacggagg aagcccggga gggaauuaag     1020

caguugcuca agcaaggcuc ugugcagaaa guuuacaaug gucugcaggg guauuga        1077


<210>  8190
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJB11__Homo_sapiens__AAF61711

<400>  8190
auggcccccc agaaccugag caccuucugc cugcugcugc uguaccugau cggcgccgug       60

aucgccggca gagacuucua caagauccug ggcgugccca gaagcgccag caucaaggac      120

aucaagaagg ccuacagaaa gcuggcccug cagcugcacc ccgacagaaa ccccgacgac      180

ccccaggccc aggagaaguu ccaggaccug ggcgccgccu acgaggugcu gagcgacagc      240

gagaagagaa agcaguacga caccuacggc gaggagggcc ugaaggacgg ccaccagagc      300

agccacggcg acaucuucag ccacuucuuc ggcgacuucg gcuucauguu cggcggcacc      360

cccagacagc aggacagaaa cauccccaga ggcagcgaca ucaucgugga ccuggaggug      420

acccuggagg agguguacgc cggcaacuuc guggaggugg ugagaaacaa gcccguggcc      480

agacaggccc ccggcaagag aaagugcaac ugcagacagg agaugagaac cacccagcug      540

ggccccggca gauuccagau gacccaggag guggugugcg acgagugccc caacgugaag      600

cuggugaacg aggagagaac ccuggaggug gagaucgagc ccggcgugag agacggcaug      660

gaguaccccu ucaucggcga gggcgagccc cacguggacg gcgagcccgg cgaccugaga      720

uucagaauca agguggugaa gcaccccauc uucgagagaa gaggcgacga ccuguacacc      780

aacgugacca ucagccuggu ggagagccug gugggcuucg agauggacau cacccaccug      840

gacggccaca aggugcacau cagcagagac aagaucacca gacccggcgc caagcugugg      900

aagaagggcg agggccugcc caacuucgac aacaacaaca ucaagggcag ccugaucauc      960

accuucgacg uggacuuccc caaggagcag cugaccgagg aggccagaga gggcaucaag     1020

cagcugcuga agcagggcag cgugcagaag guguacaacg gccugcaggg cuacuga        1077


<210>  8191
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJB11__Homo_sapiens__AAF61711

<400>  8191
auggcucccc agaaccugag caccuucugc cuccugcuuc uguaccucau cggcgccgug       60

auugccggga gagacuuuua uaagauccug ggagucccuc gguccgcguc uauuaaagau      120

aucaagaagg cuuaccgcaa acuugcccug caacuccacc cggacagaaa ucccgaugac      180

ccucaggccc aggagaaauu ccaggaucug ggcgcugccu augaaguucu gagcgacucc      240

gagaagcgga agcaauacga uacauauggg gaagagggac ucaaagacgg ccaucagucu      300

agccacgggg auaucuuuuc ccauuucuuu ggagacuucg gcuuuauguu cggcgggacg      360

ccccgccagc aggauagaaa cauuccucgg ggaucugaca ucauugugga ucuggaagug      420

acccuugagg aggucuacgc uggcaauuuu guggaaguug ugcgcaacaa gcccgucgcc      480

agacaagcgc cugggaaacg gaaguguaau ugccgccagg agaugagaac aacccagcug      540

ggaccgggcc gguuccagau gacacaagaa gugguuugug acgagugccc caacgugaaa      600

cucgucaaug aggaacgcac ccuggaggug gaaaucgagc cuggggugag agacggaaug      660

gaauaucccu uuauuggcga gggcgagccu cacgucgaug gggaacccgg agaccuucgg      720

uuccgcauca agguugugaa gcauccgauu uuugagagac ggggcgauga ccuguacaca      780

aacgugacca ucagccucgu cgaaucccug gugggguucg agauggauau uacgcaccug      840

gacggacaca aaguucauau cagcagagau aagaucaccc gcccuggcgc caaacucugg      900

aagaaagggg aaggacugcc caauuucgac aacaauaaca uuaagggcuc ucuuaucauu      960

acauuugaug uggacuuccc uaaagagcag cugaccgagg aagcucggga gggcaucaag     1020

cagcuccuga agcaaggguc cguccagaaa guguacaaug gacuucaggg cuauuga        1077


<210>  8192
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJB13__Homo_sapiens__P59910

<400>  8192

Met Gly Gln Asp Tyr Tyr Ser Val Leu Gly Ile Thr Arg Asn Ser Glu 
1               5                   10                  15      


Asp Ala Gln Ile Lys Gln Ala Tyr Arg Arg Leu Ala Leu Lys His His 
            20                  25                  30          


Pro Leu Lys Ser Asn Glu Pro Ser Ser Ala Glu Ile Phe Arg Gln Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Met Lys Arg Gly Ile Tyr 
    50                  55                  60                  


Asp Lys Phe Gly Glu Glu Gly Leu Lys Gly Gly Ile Pro Leu Glu Phe 
65                  70                  75                  80  


Gly Ser Gln Thr Pro Trp Thr Thr Gly Tyr Val Phe His Gly Lys Pro 
                85                  90                  95      


Glu Lys Val Phe His Glu Phe Phe Gly Gly Asn Asn Pro Phe Ser Glu 
            100                 105                 110         


Phe Phe Asp Ala Glu Gly Ser Glu Val Asp Leu Asn Phe Gly Gly Leu 
        115                 120                 125             


Gln Gly Arg Gly Val Lys Lys Gln Asp Pro Gln Val Glu Arg Asp Leu 
    130                 135                 140                 


Tyr Leu Ser Leu Glu Asp Leu Phe Phe Gly Cys Thr Lys Lys Ile Lys 
145                 150                 155                 160 


Ile Ser Arg Arg Val Leu Asn Glu Asp Gly Tyr Ser Ser Thr Ile Lys 
                165                 170                 175     


Asp Lys Ile Leu Thr Ile Asp Val Lys Pro Gly Trp Arg Gln Gly Thr 
            180                 185                 190         


Arg Ile Thr Phe Glu Lys Glu Gly Asp Gln Gly Pro Asn Ile Ile Pro 
        195                 200                 205             


Ala Asp Ile Ile Phe Ile Val Lys Glu Lys Leu His Pro Arg Phe Arg 
    210                 215                 220                 


Arg Glu Asn Asp Asn Leu Phe Phe Val Asn Pro Ile Pro Leu Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Cys Cys Thr Val Glu Val Arg Thr Leu Asp Asp Arg Leu 
                245                 250                 255     


Leu Asn Ile Pro Ile Asn Asp Ile Ile His Pro Lys Tyr Phe Lys Lys 
            260                 265                 270         


Val Pro Gly Glu Gly Met Pro Leu Pro Glu Asp Pro Thr Lys Lys Gly 
        275                 280                 285             


Asp Leu Phe Ile Phe Phe Asp Ile Gln Phe Pro Thr Arg Leu Thr Pro 
    290                 295                 300                 


Gln Lys Lys Gln Met Leu Arg Gln Ala Leu Leu Thr 
305                 310                 315     


<210>  8193
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJB13__Homo_sapiens__AAN15929

<400>  8193
augggccagg auuauuacuc ugugcucggg aucacucgca auucagagga ugcccagauc       60

aagcaggcgu accgcagacu cgcccuuaag caccacccgu ugaagucaaa ugagccgucu      120

ucagcagaga uuuucaggca aauagcagag gccuacgacg ugcugaguga ccccaugaag      180

agaggcaucu acgacaaguu uggagaagag ggccugaagg gugggauucc uuuggaguuu      240

ggaucccaga ccccauggac aacugguuac gucuuccacg gcaaaccuga aaagguguuc      300

cacgaguucu uugguggaaa caaccccuuc agugaguuuu uugaugcaga aggaagugag      360

guagauuuga acuuuggggg gcuccagggc cgagggguca agaagcagga cccccaaguc      420

gaacgggauc ucuaccuguc ccuggaggac uuauucuuug gcugcaccaa aaaaauuaag      480

aucuccagaa gggugcugaa cgaggauggg uacuccucca ccaucaagga caagauccug      540

accauugaug ugaagcccgg uuggaggcag ggcacacgca ucaccuuuga gaaggaaggg      600

gaccagggcc ccaacaucau cccagcagac aucauuuuca ucguaaagga gaagcuacac      660

ccucgcuucc gcagggagaa ugacaaccuc uucuucguga accccauccc ucuuggcaag      720

gcucucaccu gcugcacugu ggaggugagg acccuagaug accgucugcu caacaucccc      780

aucaaugaca ucauccaccc caaauacuuc aagaaggugc caggggaggg gaugccauug      840

ccggaggacc ccacuaagaa aggggaucuc uucaucuucu ucgacaucca guuccccacc      900

cgccucacac cccagaagaa gcagaugcug cgccaggcau ugcugacaug a               951


<210>  8194
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJB13__Homo_sapiens__AAN15929

<400>  8194
augggccagg acuacuacag cgugcugggg aucacccgca acuccgagga cgcccagauc       60

aagcaggccu accggcgccu cgcgcugaag caccaccccc ucaagagcaa cgagccgucc      120

agcgccgaga ucuuccggca gaucgccgag gccuacgacg uccuguccga ccccaugaag      180

cgcggcaucu acgacaaguu cggggaggag ggccugaagg gcgggauccc ccuggaguuc      240

ggcagccaga cccccuggac gaccggguac guguuccacg gcaagccgga gaagguguuc      300

cacgaguucu ucgggggcaa caaccccuuc uccgaguucu ucgacgccga ggggagcgag      360

gucgaccuca acuucggcgg ccugcagggg cggggcguga agaagcagga cccccaggug      420

gagcgcgacc uguaccucuc ccuggaggac cuguucuucg ggugcaccaa gaagaucaag      480

aucagccggc gcguccucaa cgaggacggc uacuccagca ccaucaagga caagauccug      540

acgaucgacg ugaagcccgg cuggcggcag gggacccgca ucaccuucga gaaggagggc      600

gaccaggggc cgaacaucau ccccgcggac aucaucuuca ucgugaagga gaagcugcac      660

ccccgguucc gccgggagaa cgacaaccuc uucuucguca accccauccc gcugggcaag      720

gcccugaccu gcugcacggu ggaggugcgc acccucgacg accggcugcu gaacaucccc      780

aucaacgaca ucauccaccc caaguacuuc aagaaggucc ccggggaggg caugccgcuc      840

cccgaggacc ccaccaagaa gggcgaccug uucaucuucu ucgacaucca guuccccacc      900

cgccugacgc cgcagaagaa gcagaugcuc cggcaggccc ugcugaccug a               951


<210>  8195
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJB13__Homo_sapiens__AAN15929

<400>  8195
augggccagg acuacuacuc cguccucggc aucacccgca acuccgagga cgcccagauc       60

aagcaggccu accgccgccu cgcccucaag caccaccccc ucaaguccaa cgagcccucc      120

uccgccgaga ucuuccgcca gaucgccgag gccuacgacg uccucuccga ccccaugaag      180

cgcggcaucu acgacaaguu cggcgaggag ggccucaagg gcggcauccc ccucgaguuc      240

ggcucccaga cccccuggac caccggcuac gucuuccacg gcaagcccga gaaggucuuc      300

cacgaguucu ucggcggcaa caaccccuuc uccgaguucu ucgacgccga gggcuccgag      360

gucgaccuca acuucggcgg ccuccagggc cgcggcguca agaagcagga cccccagguc      420

gagcgcgacc ucuaccucuc ccucgaggac cucuucuucg gcugcaccaa gaagaucaag      480

aucucccgcc gcguccucaa cgaggacggc uacuccucca ccaucaagga caagauccuc      540

accaucgacg ucaagcccgg cuggcgccag ggcacccgca ucaccuucga gaaggagggc      600

gaccagggcc ccaacaucau ccccgccgac aucaucuuca ucgucaagga gaagcuccac      660

ccccgcuucc gccgcgagaa cgacaaccuc uucuucguca accccauccc ccucggcaag      720

gcccucaccu gcugcaccgu cgagguccgc acccucgacg accgccuccu caacaucccc      780

aucaacgaca ucauccaccc caaguacuuc aagaaggucc ccggcgaggg caugccccuc      840

cccgaggacc ccaccaagaa gggcgaccuc uucaucuucu ucgacaucca guuccccacc      900

cgccucaccc cccagaagaa gcagaugcuc cgccaggccc uccucaccug a               951


<210>  8196
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJB13__Homo_sapiens__AAN15929

<400>  8196
augggccagg acuacuauag cgugcugggg aucaccagaa acuccgagga ugcccaaauu       60

aagcaggcuu acaggcggcu cgcacuuaaa caccaucccc ugaagucuaa ugaaccuuca      120

agugccgaga uauuccgcca gaucgcggag gcuuaugacg ucuugagcga uccaaugaaa      180

cgaggaauuu acgacaaguu uggugaagaa ggcuuaaaag ggggaauccc gcuggaguuc      240

ggcucccaga cacccuggac uacggguuau guuuuucacg ggaagccuga gaagguguuc      300

caugaauuuu ucggaggcaa caauccauuu ucugaguucu uugaugccga aggcucggag      360

guagaccuaa acuucggggg acuccaaggu cguggcguga aaaagcagga uccccagguc      420

gagagagacc uguaccuuuc acuggaagau uuguuuuucg ggugcaccaa aaagauuaaa      480

aucagcaggc gggugcucaa ugaggacgga uauaguucca caauaaagga uaagauccug      540

acuauugacg uuaaaccugg cuggcgccag gguaccagaa ucacauuuga aaaggagggg      600

gaucaaggac caaacauuau ccccgcagac auaauuuuca ucgugaaaga aaagcugcac      660

ccuagguucc ggcgcgagaa ugacaaccuc uuuuucguca auccaauucc guuaggcaaa      720

gcccugaccu guugcacugu ggagguacga acacuugaug acagauugcu gaacaucccc      780

aucaaugaua uuauacaucc uaaguacuuu aaaaagguuc caggcgaagg gaugccccua      840

ccugaggacc caaccaagaa aggagaucuc uucaucuuuu ucgacauuca guuucccacg      900

aggcugacuc cgcagaagaa acagaugcuu cggcaagcuc uguugaccug a               951


<210>  8197
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJB13__Homo_sapiens__AAN15929

<400>  8197
augggccagg acuacuacag cgugcugggc aucaccagaa acagcgagga cgcccagauc       60

aagcaggccu acagaagacu ggcccugaag caccaccccc ugaagagcaa cgagcccagc      120

agcgccgaga ucuucagaca gaucgccgag gccuacgacg ugcugagcga ccccaugaag      180

agaggcaucu acgacaaguu cggcgaggag ggccugaagg gcggcauccc ccuggaguuc      240

ggcagccaga cccccuggac caccggcuac guguuccacg gcaagcccga gaagguguuc      300

cacgaguucu ucggcggcaa caaccccuuc agcgaguucu ucgacgccga gggcagcgag      360

guggaccuga acuucggcgg ccugcagggc agaggcguga agaagcagga cccccaggug      420

gagagagacc uguaccugag ccuggaggac cuguucuucg gcugcaccaa gaagaucaag      480

aucagcagaa gagugcugaa cgaggacggc uacagcagca ccaucaagga caagauccug      540

accaucgacg ugaagcccgg cuggagacag ggcaccagaa ucaccuucga gaaggagggc      600

gaccagggcc ccaacaucau ccccgccgac aucaucuuca ucgugaagga gaagcugcac      660

cccagauuca gaagagagaa cgacaaccug uucuucguga accccauccc ccugggcaag      720

gcccugaccu gcugcaccgu ggaggugaga acccuggacg acagacugcu gaacaucccc      780

aucaacgaca ucauccaccc caaguacuuc aagaaggugc ccggcgaggg caugccccug      840

cccgaggacc ccaccaagaa gggcgaccug uucaucuucu ucgacaucca guuccccacc      900

agacugaccc cccagaagaa gcagaugcug agacaggccc ugcugaccug a               951


<210>  8198
<211>  951
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJB13__Homo_sapiens__AAN15929

<400>  8198
augggccagg acuacuauag cgugcugggg aucaccagaa acuccgagga ugcccaaauu       60

aagcaggcuu accggcgccu cgcccugaaa caccaucccc uuaagucuaa ugaaccuagc      120

uccgcggaga ucuucagaca gauugcugaa gccuaugacg uccugucuga uccgaugaaa      180

cggggaaucu acgacaaguu uggcgaggaa gggcucaaag gaggcauucc ccuggaguuc      240

gggagccaga caccuuggac gaccggauau guuuuucacg gcaagcccga gaagguguuc      300

caugaauuuu ucggcgggaa caauccuuuu uccgaguucu uugaugccga aggaucugag      360

guggaccuua acuucggcgg gcugcaagga cgcggcguca aaaagcagga uccccaggug      420

gagagagacc ucuaccugag ccuggaagau cucuuuuucg ggugcaccaa aaagaucaaa      480

aucucccggc gcguucugaa ugaggacgga uauagcucua caauuaagga uaagauccuu      540

acaauugacg ugaaaccugg cuggagacag ggcacccgga ucacauuuga aaaggagggg      600

gaucaaggac cgaacauuau ccccgcugac auuaucuuca ucgucaaaga aaagcugcac      660

ccucgcuuca gacgggagaa ugacaaccuc uuuuucguga aucccauucc ucugggcaaa      720

gcccuuaccu guugcacggu ugaggugcgc acccuggaug acagacuccu gaacaucccc      780

auuaaugaua ucauucaucc gaaguacuuu aaaaaggucc cuggggaagg aaugccccug      840

ccugaggacc ccacaaagaa aggcgaucuc uucaucuuuu ucgacaucca guuucccacc      900

cggcugacac cucagaagaa acagaugcuu cgccaagcuc ugcucaccug a               951


<210>  8199
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJB14__Homo_sapiens__Q8TBM8

<400>  8199

Met Glu Gly Asn Arg Asp Glu Ala Glu Lys Cys Val Glu Ile Ala Arg 
1               5                   10                  15      


Glu Ala Leu Asn Ala Gly Asn Arg Glu Lys Ala Gln Arg Phe Leu Gln 
            20                  25                  30          


Lys Ala Glu Lys Leu Tyr Pro Leu Pro Ser Ala Arg Ala Leu Leu Glu 
        35                  40                  45              


Ile Ile Met Lys Asn Gly Ser Thr Ala Gly Asn Ser Pro His Cys Arg 
    50                  55                  60                  


Lys Pro Ser Gly Ser Gly Asp Gln Ser Lys Pro Asn Cys Thr Lys Asp 
65                  70                  75                  80  


Ser Thr Ser Gly Ser Gly Glu Gly Gly Lys Gly Tyr Thr Lys Asp Gln 
                85                  90                  95      


Val Asp Gly Val Leu Ser Ile Asn Lys Cys Lys Asn Tyr Tyr Glu Val 
            100                 105                 110         


Leu Gly Val Thr Lys Asp Ala Gly Asp Glu Asp Leu Lys Lys Ala Tyr 
        115                 120                 125             


Arg Lys Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala Pro Gly 
    130                 135                 140                 


Ala Thr Asp Ala Phe Lys Lys Ile Gly Asn Ala Tyr Ala Val Leu Ser 
145                 150                 155                 160 


Asn Pro Glu Lys Arg Lys Gln Tyr Asp Leu Thr Gly Asn Glu Glu Gln 
                165                 170                 175     


Ala Cys Asn His Gln Asn Asn Gly Arg Phe Asn Phe His Arg Gly Cys 
            180                 185                 190         


Glu Ala Asp Ile Thr Pro Glu Asp Leu Phe Asn Ile Phe Phe Gly Gly 
        195                 200                 205             


Gly Phe Pro Ser Gly Ser Val His Ser Phe Ser Asn Gly Arg Ala Gly 
    210                 215                 220                 


Tyr Ser Gln Gln His Gln His Arg His Ser Gly His Glu Arg Glu Glu 
225                 230                 235                 240 


Glu Arg Gly Asp Gly Gly Phe Ser Val Phe Ile Gln Leu Met Pro Ile 
                245                 250                 255     


Ile Val Leu Ile Leu Val Ser Leu Leu Ser Gln Leu Met Val Ser Asn 
            260                 265                 270         


Pro Pro Tyr Ser Leu Tyr Pro Arg Ser Gly Thr Gly Gln Thr Ile Lys 
        275                 280                 285             


Met Gln Thr Glu Asn Leu Gly Val Val Tyr Tyr Val Asn Lys Asp Phe 
    290                 295                 300                 


Lys Asn Glu Tyr Lys Gly Met Leu Leu Gln Lys Val Glu Lys Ser Val 
305                 310                 315                 320 


Glu Glu Asp Tyr Val Thr Asn Ile Arg Asn Asn Cys Trp Lys Glu Arg 
                325                 330                 335     


Gln Gln Lys Thr Asp Met Gln Tyr Ala Ala Lys Val Tyr Arg Asp Asp 
            340                 345                 350         


Arg Leu Arg Arg Lys Ala Asp Ala Leu Ser Met Asp Asn Cys Lys Glu 
        355                 360                 365             


Leu Glu Arg Leu Thr Ser Leu Tyr Lys Gly Gly 
    370                 375                 


<210>  8200
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJB14__Homo_sapiens__AAH22248

<400>  8200
auggagggga acagggauga ggcugagaaa ugugucgaga ucgcccggga ggcccugaac       60

gccggcaacc gcgagaaggc ccagcgcuuc cugcagaagg ccgagaagcu cuacccacug      120

cccucggccc gcgcacuauu ggaaauaauu augaaaaaug gaagcacggc uggaaauagc      180

ccucauugcc gaaaaccauc agguaguggc gaucaaagca agccuaauug cacaaaggac      240

agcacaucug guagugguga agguggaaaa ggcuauacca aagaccaagu agauggaguu      300

cucagcauaa acaaauguaa aaauuacuau gaaguacuug gaguuacgaa agaugcuggu      360

gaugaagauu ugaaaaaagc uuauagaaag cuugcuuuga aguuucaucc agacaaaaac      420

caugcaccug gagcaacaga ugcuuuuaaa aagauuggaa augcuuaugc uguuuuaagu      480

aauccagaaa agcgaaaaca guaugaccuc acgggcaaug aagaacaagc auguaaccac      540

caaaacaaug gcagauuuaa uuuccauaga gguugugaag cugauauaac uccagaagac      600

uuguuuaaua uauuuuuugg ggguggauuu ccuucaggua guguacauuc uuuuucaaau      660

ggaagagcug guuauagcca acaacaucag caucgacaua guggacauga aagagaagag      720

gaaagaggag auggagguuu uucuguguuu auccagcuga ugcccauaau uguauugauc      780

cucgugucau uauuaagcca guugaugguc ucuaauccuc cuuauuccuu auaucccaga      840

ucuggaacug ggcaaacuau uaaaaugcaa acagaaaacu uggguguugu uuauuauguc      900

aacaaggacu ucaaaaauga auauaaagga auguuauuac aaaagguaga aaagagugug      960

gaggaagauu augugacuaa uauucgaaau aacugcugga aagaaagaca acaaaaaaca     1020

gauaugcagu augcagcaaa aguauaccgu gaugaucgac uccgaaggaa ggcagaugcc     1080

uugagcaugg acaacuguaa agaauuagag cggcuuacca gucuuuauaa aggaggauga     1140


<210>  8201
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJB14__Homo_sapiens__AAH22248

<400>  8201
auggagggca accgcgacga ggccgagaag ugcguggaga ucgcccggga ggcgcugaac       60

gccgggaacc gcgagaaggc ccagcgguuc cuccagaagg ccgagaagcu guacccccug      120

ccgagcgccc gcgcgcuccu ggagaucauc augaagaacg gcuccaccgc cgggaacagc      180

ccccacugcc ggaagcccuc cggcagcggg gaccagucca agcccaacug caccaaggac      240

agcacguccg gcagcggcga gggcgggaag ggguacacca aggaccaggu cgacggcgug      300

cuguccauca acaagugcaa gaacuacuac gaggugcucg gggucaccaa ggacgccggc      360

gacgaggacc ugaagaaggc cuaccgcaag cuggcgcuca aguuccaccc ggacaagaac      420

cacgcccccg gcgccaccga cgccuucaag aagaucggga acgccuacgc ggugcugagc      480

aaccccgaga agcggaagca guacgaccug acgggcaacg aggagcaggc cugcaaccac      540

cagaacaacg ggcgcuucaa cuuccaccgg ggcugcgagg ccgacaucac ccccgaggac      600

cucuucaaca ucuucuucgg cgggggcuuc ccguccggga gcgugcacuc cuucagcaac      660

ggccgcgccg gguacuccca gcagcaccag caccggcaca gcggccacga gcgcgaggag      720

gagcggggcg acgggggcuu cuccgucuuc auccagcuga ugcccaucau cgugcugauc      780

cucgugagcc ugcuguccca gcucaugguc agcaacccgc ccuacagccu guacccccgc      840

uccgggaccg gccagaccau caagaugcag acggagaacc uggggguggu guacuacguc      900

aacaaggacu ucaagaacga guacaagggc augcuccugc agaaggugga gaaguccgug      960

gaggaggacu acgucaccaa cauccggaac aacugcugga aggagcgcca gcagaagacc     1020

gacaugcagu acgccgcgaa gguguaccgg gacgaccgcc ugcggcgcaa ggccgacgcc     1080

cucagcaugg acaacugcaa ggagcuggag cggcugacca gccucuacaa gggcggguga     1140


<210>  8202
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJB14__Homo_sapiens__AAH22248

<400>  8202
auggagggca accgcgacga ggccgagaag ugcgucgaga ucgcccgcga ggcccucaac       60

gccggcaacc gcgagaaggc ccagcgcuuc cuccagaagg ccgagaagcu cuacccccuc      120

cccuccgccc gcgcccuccu cgagaucauc augaagaacg gcuccaccgc cggcaacucc      180

ccccacugcc gcaagcccuc cggcuccggc gaccagucca agcccaacug caccaaggac      240

uccaccuccg gcuccggcga gggcggcaag ggcuacacca aggaccaggu cgacggcguc      300

cucuccauca acaagugcaa gaacuacuac gagguccucg gcgucaccaa ggacgccggc      360

gacgaggacc ucaagaaggc cuaccgcaag cucgcccuca aguuccaccc cgacaagaac      420

cacgcccccg gcgccaccga cgccuucaag aagaucggca acgccuacgc cguccucucc      480

aaccccgaga agcgcaagca guacgaccuc accggcaacg aggagcaggc cugcaaccac      540

cagaacaacg gccgcuucaa cuuccaccgc ggcugcgagg ccgacaucac ccccgaggac      600

cucuucaaca ucuucuucgg cggcggcuuc cccuccggcu ccguccacuc cuucuccaac      660

ggccgcgccg gcuacuccca gcagcaccag caccgccacu ccggccacga gcgcgaggag      720

gagcgcggcg acggcggcuu cuccgucuuc auccagcuca ugcccaucau cguccucauc      780

cucgucuccc uccucuccca gcucaugguc uccaaccccc ccuacucccu cuacccccgc      840

uccggcaccg gccagaccau caagaugcag accgagaacc ucggcgucgu cuacuacguc      900

aacaaggacu ucaagaacga guacaagggc augcuccucc agaaggucga gaaguccguc      960

gaggaggacu acgucaccaa cauccgcaac aacugcugga aggagcgcca gcagaagacc     1020

gacaugcagu acgccgccaa ggucuaccgc gacgaccgcc uccgccgcaa ggccgacgcc     1080

cucuccaugg acaacugcaa ggagcucgag cgccucaccu cccucuacaa gggcggcuga     1140


<210>  8203
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJB14__Homo_sapiens__AAH22248

<400>  8203
auggagggca acagagacga agccgagaag ugcguggaaa ucgcuaggga ggcacugaau       60

gccgggaacc gggaaaaagc gcagcgcuuc cuccaaaagg cugagaaacu uuacccccug      120

ccuagcgccc gagcauuguu agagauuaua augaagaaug gauccaccgc cgguaacucu      180

ccacacuguc guaaaccguc aggcaguggg gaucagagca agcccaauug cacaaaggac      240

uccacuucug gaucgggcga aggugggaaa ggauauacga aggaucaggu cgacggcguu      300

cugucaauca acaaauguaa gaauuacuau gaggugcuag gcguaaccaa agaugcuggg      360

gacgaagauc ucaagaaggc auacagaaaa cuggcccuua aguuucaucc ugacaaaaac      420

cacgcuccag gagccacaga ugcguucaag aaaauuggua augcauaugc cgugcugagc      480

aaccccgaga agaggaaaca guacgacuug acuggcaaug aggaacaggc uugcaaccau      540

caaaauaacg ggcgguuuaa uuuccaccgc ggaugugagg ccgauaucac cccugaagac      600

cucuuuaaca uuuucuuugg cgguggguuc ccaaguggau ccguccauuc uuuuagcaac      660

ggcagagcag gcuauuccca gcagcaccaa cacaggcauu cagggcacga gcgggaagag      720

gagcgcggag augguggcuu caguguguuu auccagcuga ugcccauaau cguucugauu      780

cucgugagcu uacugucuca gcuuaugguc uccaauccuc cauacucauu guacccgcga      840

agcgggacag gacagaccau caagaugcaa acugaaaacc ugggcguggu auauuacguu      900

aauaaggacu ucaaaaacga guauaagggu augcuacucc agaaagugga aaagaguguc      960

gaggaagacu acgugacaaa uauuagaaac aauugcugga aagagaggca gcaaaagacc     1020

gauaugcagu augcugccaa gguguaccgg gacgaucguc ugcgcagaaa agcggacgcc     1080

cuuucuaugg auaacuguaa ggagcuggaa agguugacgu cccucuauaa agggggcuga     1140


<210>  8204
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJB14__Homo_sapiens__AAH22248

<400>  8204
auggagggca acagagacga ggccgagaag ugcguggaga ucgccagaga ggcccugaac       60

gccggcaaca gagagaaggc ccagagauuc cugcagaagg ccgagaagcu guacccccug      120

cccagcgcca gagcccugcu ggagaucauc augaagaacg gcagcaccgc cggcaacagc      180

ccccacugca gaaagcccag cggcagcggc gaccagagca agcccaacug caccaaggac      240

agcaccagcg gcagcggcga gggcggcaag ggcuacacca aggaccaggu ggacggcgug      300

cugagcauca acaagugcaa gaacuacuac gaggugcugg gcgugaccaa ggacgccggc      360

gacgaggacc ugaagaaggc cuacagaaag cuggcccuga aguuccaccc cgacaagaac      420

cacgcccccg gcgccaccga cgccuucaag aagaucggca acgccuacgc cgugcugagc      480

aaccccgaga agagaaagca guacgaccug accggcaacg aggagcaggc cugcaaccac      540

cagaacaacg gcagauucaa cuuccacaga ggcugcgagg ccgacaucac ccccgaggac      600

cuguucaaca ucuucuucgg cggcggcuuc cccagcggca gcgugcacag cuucagcaac      660

ggcagagccg gcuacagcca gcagcaccag cacagacaca gcggccacga gagagaggag      720

gagagaggcg acggcggcuu cagcguguuc auccagcuga ugcccaucau cgugcugauc      780

cuggugagcc ugcugagcca gcugauggug agcaaccccc ccuacagccu guaccccaga      840

agcggcaccg gccagaccau caagaugcag accgagaacc ugggcguggu guacuacgug      900

aacaaggacu ucaagaacga guacaagggc augcugcugc agaaggugga gaagagcgug      960

gaggaggacu acgugaccaa caucagaaac aacugcugga aggagagaca gcagaagacc     1020

gacaugcagu acgccgccaa gguguacaga gacgacagac ugagaagaaa ggccgacgcc     1080

cugagcaugg acaacugcaa ggagcuggag agacugacca gccuguacaa gggcggcuga     1140


<210>  8205
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJB14__Homo_sapiens__AAH22248

<400>  8205
auggagggca acagagacga agccgagaag ugcguggaaa ucgcucggga ggcccugaau       60

gcggggaacc gcgaaaaagc ucagagauuc cuccaaaagg ccgagaaacu guacccccuu      120

ccuagcgccc gggcucugcu cgagauuauc augaagaaug gauccaccgc cggcaacucu      180

ccgcacuguc gcaaacccag cggguccgga gaucagucua agccuaauug cacaaaggac      240

agcacguccg gcucugggga aggaggcaaa ggcuauacca aggaucaggu cgacgggguu      300

cugagcauua acaaauguaa gaauuacuau gaggugcuug gagugacaaa agaugcuggc      360

gacgaagauc ugaagaaggc cuacagaaaa cucgcgcuga aguuucaucc cgacaaaaac      420

cacgccccug gggcuaccga ugccuucaag aaaaucggaa augcuuaugc cguccugucc      480

aaccccgaga agcggaaaca guacgaccuc acaggcaaug aggaacaagc gugcaaccau      540

cagaauaacg ggcgcuuuaa uuuccacaga ggaugugagg ccgauauuac cccugaagac      600

cuguuuaaca ucuucuuugg cggcggguuc ccgagcggau cugugcauuc cuuuagcaac      660

ggccgggcug gguauucuca gcagcaccaa caccgccauu ccggacacga gagagaagag      720

gagcggggcg augggggauu cagcguuuuu auccagcuua ugcccauuau cgugcugauu      780

cucgucucuc ugcuuuccca gcugauggug agcaauccuc ccuacucccu cuacccucgc      840

ucuggcacag gccagaccau caagaugcaa acggaaaacc uggggguugu guauuacguc      900

aauaaggacu ucaaaaacga guauaaggga augcugcucc agaaagugga aaagagcgug      960

gaggaagacu acgucaccaa uauuagaaac aauugcugga aagagcggca gcaaaagaca     1020

gauaugcagu augccgcuaa gguuuaccgc gacgauagac ugcggagaaa agccgacgcc     1080

cuuuccaugg auaacuguaa ggagcuggaa cgccucacca gccuguauaa aggcggguga     1140


<210>  8206
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC10__Homo_sapiens__Q8IXB1

<400>  8206

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Asp Gly Leu Val Asn 
        275                 280                 285             


Val Gly Trp Met Asp Cys Ala Thr Gln Asp Asn Leu Cys Lys Ser Leu 
    290                 295                 300                 


Asp Ile Thr Thr Ser Thr Thr Ala Tyr Phe Pro Pro Gly Ala Thr Leu 
305                 310                 315                 320 


Asn Asn Lys Glu Lys Asn Ser Ile Leu Phe Leu Asn Ser Leu Asp Ala 
                325                 330                 335     


Lys Glu Ile Tyr Leu Glu Val Ile His Asn Leu Pro Asp Phe Glu Leu 
            340                 345                 350         


Leu Ser Ala Asn Thr Leu Glu Asp Arg Leu Ala His His Arg Trp Leu 
        355                 360                 365             


Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Pro Glu Leu 
    370                 375                 380                 


Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln Val Gly Arg 
385                 390                 395                 400 


Phe Asp Cys Ser Ser Ala Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe 
                405                 410                 415     


Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu 
            420                 425                 430         


Ile His His Gly Lys Lys Ile Leu Tyr Asp Ile Leu Ala Phe Ala Lys 
        435                 440                 445             


Glu Ser Val Asn Ser His Val Thr Thr Leu Gly Pro Gln Asn Phe Pro 
    450                 455                 460                 


Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys 
465                 470                 475                 480 


Pro Pro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu 
                485                 490                 495     


Leu Tyr Gly Gln Leu Lys Phe Gly Thr Leu Asp Cys Thr Val His Glu 
            500                 505                 510         


Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val 
        515                 520                 525             


Phe Asn Gln Ser Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu 
    530                 535                 540                 


Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser 
545                 550                 555                 560 


Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn 
                565                 570                 575     


Glu Val Trp Met Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln 
            580                 585                 590         


Val Leu Met Pro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu 
        595                 600                 605             


Ile Asn Val Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala 
    610                 615                 620                 


Gln Glu Asn Val Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys 
625                 630                 635                 640 


Ser Asn Lys Ala Tyr His Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp 
                645                 650                 655     


Ala Tyr Ser Leu Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser 
            660                 665                 670         


Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys 
        675                 680                 685             


Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln 
    690                 695                 700                 


Asn Phe Ala Pro Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys 
705                 710                 715                 720 


Val Lys Ala Gly Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln 
                725                 730                 735     


Lys Ala Gly Ile Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu 
            740                 745                 750         


Arg Ala Lys Arg Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala 
        755                 760                 765             


Lys Ala Ile Ala Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn 
    770                 775                 780                 


Gln Gly Lys Arg Asn Lys Asp Glu Leu 
785                 790             


<210>  8207
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC10__Homo_sapiens__BAB55263

<400>  8207
augggagucu gguuaaauaa agaugacuau aucagagacu ugaaaaggau cauucucugu       60

uuucugauag uguauauggc cauuuuagug ggcacagauc aggauuuuua caguuuacuu      120

ggagugucca aaacugcaag caguagagaa auaagacaag cuuucaagaa auuggcauug      180

aaguuacauc cugauaaaaa cccgaauaac ccaaaugcac auggcgauuu uuuaaaaaua      240

aauagagcau augaaguacu caaagaugaa gaucuacgga aaaaguauga caaauaugga      300

gaaaagggac uugaggauaa ucaagguggc caguaugaaa gcuggaacua uuaucguuau      360

gauuuuggua uuuaugauga ugauccugaa aucauaacau uggaaagaag agaauuugau      420

gcugcuguua auucuggaga acugugguuu guaaauuuuu acuccccagg cuguucacac      480

ugccaugauu uagcucccac auggagagac uuugcuaaag aaguggaugg guuacuucga      540

auuggagcug uuaacugugg ugaugauaga augcuuugcc gaaugaaagg agucaacagc      600

uaucccagcc ucuucauuuu ucggucugga auggccccag ugaaauauca uggagacaga      660

ucaaaggaga guuuagugag uuuugcaaug cagcauguua gaaguacagu gacagaacuu      720

uggacaggaa auuuugucaa cuccauacaa acugccuuug cugcugguau uggcuggcug      780

aucacuuuuu guucaaaagg aggagauugu uugacuucac agacacgacu caggcuuagu      840

ggcauguugg auggucuugu uaauguagga uggauggacu gugccaccca ggauaaccuu      900

uguaaaagcu uagauauuac aacaaguacu acugcuuauu uuccuccugg agccacuuua      960

aauaacaaag agaaaaacag uauuuuguuu cucaacucau uggaugcuaa agaaauauau     1020

uuggaaguaa uacauaaucu uccagauuuu gaacuacuuu cggcaaacac acuagaggau     1080

cguuuggcuc aucaucggug gcuguuauuu uuucauuuug gaaaaaauga aaauucaaau     1140

gauccugagc ugaaaaaacu aaaaacucua cuuaaaaaug aucauauuca aguuggcagg     1200

uuugacuguu ccucugcacc agacaucugu aguaaucugu auguuuuuca gccgucucua     1260

gcaguauuua aaggacaagg aaccaaagaa uaugaaauuc aucauggaaa gaagauucua     1320

uaugauauac uugccuuugc caaagaaagu gugaauucuc auguuaccac gcuuggaccu     1380

caaaauuuuc cugccaauga caaagaacca uggcuuguug auuucuuugc ccccuggugu     1440

ccaccauguc gagcuuuacu accagaguua cgaagagcau caaaucuucu uuauggucag     1500

cuuaaguuug guacacuaga uuguacaguu caugagggac ucuguaacau guauaacauu     1560

caggcuuauc caacgacagu gguauucaac caguccaaca uucaugagua ugaaggacau     1620

cacucugcug aacaaaucuu ggaguucaua gaggaucuua ugaauccuuc aguggucucc     1680

cuuacaccca ccaccuucaa cgaacuaguu acacaaagaa aacacaacga agucuggaug     1740

guugauuucu auucuccgug gugucauccu ugccaagucu uaaugccaga auggaaaaga     1800

auggcccgga cauuaacugg acugaucaac gugggcagua uagauugcca acaguaucau     1860

ucuuuuugug cccaggaaaa cguucaaaga uacccugaga uaagauuuuu ucccccaaaa     1920

ucaaauaaag cuuaucauua ucacaguuac aaugguugga auagggaugc uuauucccug     1980

agaaucuggg gucuaggauu uuuaccucaa guauccacag aucuaacacc ucagacuuuc     2040

agugaaaaag uucuacaagg gaaaaaucau ugggugauug auuucuaugc uccuuggugu     2100

ggaccuugcc agaauuuugc uccagaauuu gagcucuugg cuaggaugau uaaaggaaaa     2160

gugaaagcug gaaaaguaga cugucaggcu uaugcucaga caugccagaa agcugggauc     2220

agggccuauc caacuguuaa auuuuauuuc uacgaaagag caaagagaaa uuuucaagaa     2280

gagcagauaa auaccagaga ugcaaaagca aucgcugccu uaauaaguga aaaauuggaa     2340

acucuccgaa aucaaggcaa gaggaauaag gaugaacuuu ga                        2382


<210>  8208
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC10__Homo_sapiens__BAB55263

<400>  8208
augggcgugu ggcugaacaa ggacgacuac auccgcgacc ucaagcggau cauccugugc       60

uuccugaucg ucuacauggc cauccucgug gggaccgacc aggacuucua cagccugcug      120

ggcgugucca agaccgccag cucccgcgag auccggcagg cguucaagaa gcucgcccug      180

aagcugcacc ccgacaagaa cccgaacaac cccaacgccc acggggacuu ccucaagauc      240

aaccgcgccu acgagguccu gaaggacgag gaccugcgga agaaguacga caaguacggc      300

gagaaggggc ucgaggacaa ccagggcggc caguacgaga gcuggaacua cuaccgcuac      360

gacuucggga ucuacgacga cgaccccgag aucaucacgc uggagcggcg cgaguucgac      420

gccgcgguga acuccggcga gcugugguuc gugaacuucu acagccccgg gugcucccac      480

ugccacgacc ucgccccgac cuggcgggac uucgccaagg aggucgacgg ccugcugcgc      540

aucggggccg ugaacugcgg cgacgaccgg augcucugcc gcaugaaggg cgugaacagc      600

uaccccuccc uguucaucuu ccggagcggg auggcgcccg ucaaguacca cggcgaccgc      660

uccaaggaga gccugguguc cuucgccaug cagcacgugc ggagcaccgu caccgagcuc      720

uggacgggga acuucgugaa cuccauccag accgccuucg ccgccggcau cggcuggcug      780

aucaccuucu gcagcaaggg cggggacugc cugaccuccc agacgcgccu ccggcugagc      840

gggaugcugg acggccucgu gaacgucggg uggauggacu gcgcgaccca ggacaaccug      900

ugcaaguccc uggacaucac caccagcacg accgccuacu ucccgccggg cgccacccuc      960

aacaacaagg agaagaacag cauccuguuc cugaacuccc ucgacgccaa ggagaucuac     1020

cuggagguga uccacaaccu gcccgacuuc gagcuccuga gcgccaacac ccuggaggac     1080

cgccucgcgc accaccggug gcugcuguuc uuccacuucg gcaagaacga gaacuccaac     1140

gaccccgagc ucaagaagcu gaagacgcug cucaagaacg accacaucca gguggggcgc     1200

uucgacugca gcuccgcccc cgacaucugc agcaaccugu acgucuucca gccgucccug     1260

gccguguuca agggccaggg gaccaaggag uacgagaucc accacggcaa gaagauccuc     1320

uacgacaucc uggccuucgc caaggagagc gugaacuccc acgucaccac ccuggggccc     1380

cagaacuucc ccgcgaacga caaggagccc uggcuggugg acuucuucgc cccguggugc     1440

ccgcccugcc gggcccuccu gcccgagcug cgccgcgcca gcaaccuccu guacggccag     1500

cugaaguucg gcacgcucga cugcaccgug cacgaggggc ugugcaacau guacaacauc     1560

caggccuacc ccaccaccgu cguguucaac caguccaaca uccacgagua cgagggccac     1620

cacagcgcgg agcagauccu ggaguucauc gaggaccuca ugaaccccuc cgucgugagc     1680

cugacgccca ccaccuucaa cgagcuggug acccagcgga agcacaacga ggucuggaug     1740

guggacuucu acucccccug gugccacccg ugccaggugc ucaugcccga guggaagcgc     1800

auggcccgga cgcugaccgg gcugaucaac gucggcagca ucgacugcca gcaguaccac     1860

uccuucugcg cccaggagaa cgugcagcgc uaccccgaga uccgguucuu cccgcccaag     1920

agcaacaagg ccuaccacua ccacuccuac aacgggugga accgcgacgc guacagccuc     1980

cggaucuggg gccugggcuu ccugccccag gugagcaccg accucacgcc ccagaccuuc     2040

uccgagaagg uccugcaggg gaagaaccac ugggugaucg acuucuacgc ccccuggugc     2100

ggccccugcc agaacuucgc ccccgaguuc gagcugcucg cccgcaugau caaggggaag     2160

gugaaggccg gcaaggucga cugccaggcg uacgcccaga ccugccagaa ggccggcauc     2220

cgggccuacc ccaccgugaa guucuacuuc uacgagcgcg ccaagcggaa cuuccaggag     2280

gagcagauca acacccgcga cgcgaaggcc aucgccgccc ugaucagcga gaagcuggag     2340

acgcuccgga accaggggaa gcgcaacaag gacgagcugu ga                        2382


<210>  8209
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC10__Homo_sapiens__BAB55263

<400>  8209
augggcgucu ggcucaacaa ggacgacuac auccgcgacc ucaagcgcau cauccucugc       60

uuccucaucg ucuacauggc cauccucguc ggcaccgacc aggacuucua cucccuccuc      120

ggcgucucca agaccgccuc cucccgcgag auccgccagg ccuucaagaa gcucgcccuc      180

aagcuccacc ccgacaagaa ccccaacaac cccaacgccc acggcgacuu ccucaagauc      240

aaccgcgccu acgagguccu caaggacgag gaccuccgca agaaguacga caaguacggc      300

gagaagggcc ucgaggacaa ccagggcggc caguacgagu ccuggaacua cuaccgcuac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc ucgagcgccg cgaguucgac      420

gccgccguca acuccggcga gcucugguuc gucaacuucu acucccccgg cugcucccac      480

ugccacgacc ucgcccccac cuggcgcgac uucgccaagg aggucgacgg ccuccuccgc      540

aucggcgccg ucaacugcgg cgacgaccgc augcucugcc gcaugaaggg cgucaacucc      600

uaccccuccc ucuucaucuu ccgcuccggc auggcccccg ucaaguacca cggcgaccgc      660

uccaaggagu cccucgucuc cuucgccaug cagcacgucc gcuccaccgu caccgagcuc      720

uggaccggca acuucgucaa cuccauccag accgccuucg ccgccggcau cggcuggcuc      780

aucaccuucu gcuccaaggg cggcgacugc cucaccuccc agacccgccu ccgccucucc      840

ggcaugcucg acggccucgu caacgucggc uggauggacu gcgccaccca ggacaaccuc      900

ugcaaguccc ucgacaucac caccuccacc accgccuacu ucccccccgg cgccacccuc      960

aacaacaagg agaagaacuc cauccucuuc cucaacuccc ucgacgccaa ggagaucuac     1020

cucgagguca uccacaaccu ccccgacuuc gagcuccucu ccgccaacac ccucgaggac     1080

cgccucgccc accaccgcug gcuccucuuc uuccacuucg gcaagaacga gaacuccaac     1140

gaccccgagc ucaagaagcu caagacccuc cucaagaacg accacaucca ggucggccgc     1200

uucgacugcu ccuccgcccc cgacaucugc uccaaccucu acgucuucca gcccucccuc     1260

gccgucuuca agggccaggg caccaaggag uacgagaucc accacggcaa gaagauccuc     1320

uacgacaucc ucgccuucgc caaggagucc gucaacuccc acgucaccac ccucggcccc     1380

cagaacuucc ccgccaacga caaggagccc uggcucgucg acuucuucgc ccccuggugc     1440

ccccccugcc gcgcccuccu ccccgagcuc cgccgcgccu ccaaccuccu cuacggccag     1500

cucaaguucg gcacccucga cugcaccguc cacgagggcc ucugcaacau guacaacauc     1560

caggccuacc ccaccaccgu cgucuucaac caguccaaca uccacgagua cgagggccac     1620

cacuccgccg agcagauccu cgaguucauc gaggaccuca ugaaccccuc cgucgucucc     1680

cucaccccca ccaccuucaa cgagcucguc acccagcgca agcacaacga ggucuggaug     1740

gucgacuucu acucccccug gugccacccc ugccaggucc ucaugcccga guggaagcgc     1800

auggcccgca cccucaccgg ccucaucaac gucggcucca ucgacugcca gcaguaccac     1860

uccuucugcg cccaggagaa cguccagcgc uaccccgaga uccgcuucuu cccccccaag     1920

uccaacaagg ccuaccacua ccacuccuac aacggcugga accgcgacgc cuacucccuc     1980

cgcaucuggg gccucggcuu ccucccccag gucuccaccg accucacccc ccagaccuuc     2040

uccgagaagg uccuccaggg caagaaccac ugggucaucg acuucuacgc ccccuggugc     2100

ggccccugcc agaacuucgc ccccgaguuc gagcuccucg cccgcaugau caagggcaag     2160

gucaaggccg gcaaggucga cugccaggcc uacgcccaga ccugccagaa ggccggcauc     2220

cgcgccuacc ccaccgucaa guucuacuuc uacgagcgcg ccaagcgcaa cuuccaggag     2280

gagcagauca acacccgcga cgccaaggcc aucgccgccc ucaucuccga gaagcucgag     2340

acccuccgca accagggcaa gcgcaacaag gacgagcucu ga                        2382


<210>  8210
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC10__Homo_sapiens__BAB55263

<400>  8210
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaaaggau uauacuuugc       60

uuccugaucg ucuauauggc cauuuugguu gggaccgauc aggacuuuua cagcuuacug      120

ggagugucca agacagcuuc uucacgggag auccgccaag cauucaaaaa gcuagcccuc      180

aaacugcacc ccgauaagaa uccuaacaau ccaaacgcgc auggugacuu ucuuaagauu      240

aaucgagcuu augaaguacu gaaagaugag gacuugcgua agaaauacga uaaguauggc      300

gaaaaagggc ucgaggacaa ccagggaggc caguacgaaa guuggaauua uuacagauac      360

gauuucggua ucuaugacga ugacccggag auaaucacuc uggagaggcg ggaauuugac      420

gccgcaguga acagcgggga gcugugguuc gucaauuuuu acucccccgg auguucucac      480

ugccaugauc ucgccccuac guggcgcgac uucgcuaagg aaguggaugg cuuacugaga      540

auuggcgcag uuaacugugg ggacgauagg augcuuugcc ggaugaaggg agucaauucg      600

uauccaucau uguuuaucuu ccgcagcggu auggcccccg ugaaauacca cggcgaccga      660

aguaaggagu cccugguguc uuuugcuaug cagcauguaa gaagcaccgu uacagagcua      720

uggacuggga acuucgucaa uuccauucaa accgccuuug cggcaggaau cggcuggcuc      780

auaacauucu guucaaaagg uggggauugc cugaccaguc agacuaggcu ucggcugagc      840

ggaauguugg acggccucgu gaacgugggc uggauggauu gugccacaca ggacaaucug      900

ugcaagucuu uagauauuac cacguccacu accgcuuauu ucccuccagg ggccacacug      960

aacaacaaag aaaagaacuc aauccucuuu cuuaauagcc uggacgcaaa agagauuuac     1020

uuggaaguga uccacaaucu acccgacuuc gagcugcuca gugcuaacac ucuggaagau     1080

cgucuugccc accaucgcug gcuguuguuu uuccacuuug gaaagaauga gaacucuaau     1140

gacccugagc ucaagaaacu gaagaccuua cugaaaaacg aucauaucca ggucgguaga     1200

uucgacuguu ccagcgcgcc agauauuugc ucgaaucuau auguuuuuca accgucucuc     1260

gccguguuca agggccaggg gacaaaagaa uacgagauac accacggaaa gaagauccug     1320

uacgacauuc uugcauuugc uaaagaaucc guaaacucac augugaccac guugggcccc     1380

cagaauuucc cugccaacga uaaggagcca uggcuggucg acuuuuucgc ucccuggugu     1440

ccuccaugca gggcccuccu gcccgaacuu cggcgagcaa guaaucuguu guauggucag     1500

cucaaauuug ggacucugga uugcacagug cacgagggcu uauguaacau guacaauauc     1560

caagccuauc cgaccacugu uguguucaac cagagcaaca uacaugagua cgaaggacac     1620

cauuccgcug agcagauucu ggaguucauc gaagaccuaa ugaauccuuc ugucgugagc     1680

cucacaccca ccacguuuaa cgaacuggua acccaacgca agcacaauga gguuuggaug     1740

guggauuucu auucaccaug gugccacccu ugucaggucc uuaugcccga guggaaaaga     1800

auggcgagga cauugacugg ccugaucaac guggggagua uugacugcca gcaguaccau     1860

uccuuuugug cacaagaaaa uguccagcgg uauccagaga uccgcuucuu ucccccuaag     1920

agcaacaagg ccuaccacua ccauucuuau aauggaugga acagagaugc uuacucacuc     1980

aggauuuggg gucugggcuu cuuaccacag gugaguaccg accugacacc gcagacuuuu     2040

agcgaaaaag uucuucaagg gaagaaucac ugggugauag acuucuaugc ccccuggugc     2100

ggaccuuguc agaacuuugc accagaguuc gaguugcucg cccguaugau caaaggcaag     2160

guaaaagcug guaaggucga uugccaggcc uacgcacaga ccugucaaaa ggcggggauu     2220

cgggcuuauc ccacagugaa auuuuacuuc uaugaacgag ccaagagaaa uuuucaggag     2280

gaacagauca acaccaggga cgcaaaagcc aucgcugccc ugauuuccga gaagcuagaa     2340

acucugcgca aucagggcaa acggaacaag gaugagcucu ga                        2382


<210>  8211
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC10__Homo_sapiens__BAB55263

<400>  8211
augggcgugu ggcugaacaa ggacgacuac aucagagacc ugaagagaau cauccugugc       60

uuccugaucg uguacauggc cauccuggug ggcaccgacc aggacuucua cagccugcug      120

ggcgugagca agaccgccag cagcagagag aucagacagg ccuucaagaa gcuggcccug      180

aagcugcacc ccgacaagaa ccccaacaac cccaacgccc acggcgacuu ccugaagauc      240

aacagagccu acgaggugcu gaaggacgag gaccugagaa agaaguacga caaguacggc      300

gagaagggcc uggaggacaa ccagggcggc caguacgaga gcuggaacua cuacagauac      360

gacuucggca ucuacgacga cgaccccgag aucaucaccc uggagagaag agaguucgac      420

gccgccguga acagcggcga gcugugguuc gugaacuucu acagccccgg cugcagccac      480

ugccacgacc uggcccccac cuggagagac uucgccaagg agguggacgg ccugcugaga      540

aucggcgccg ugaacugcgg cgacgacaga augcugugca gaaugaaggg cgugaacagc      600

uaccccagcc uguucaucuu cagaagcggc auggcccccg ugaaguacca cggcgacaga      660

agcaaggaga gccuggugag cuucgccaug cagcacguga gaagcaccgu gaccgagcug      720

uggaccggca acuucgugaa cagcauccag accgccuucg ccgccggcau cggcuggcug      780

aucaccuucu gcagcaaggg cggcgacugc cugaccagcc agaccagacu gagacugagc      840

ggcaugcugg acggccuggu gaacgugggc uggauggacu gcgccaccca ggacaaccug      900

ugcaagagcc uggacaucac caccagcacc accgccuacu ucccccccgg cgccacccug      960

aacaacaagg agaagaacag cauccuguuc cugaacagcc uggacgccaa ggagaucuac     1020

cuggagguga uccacaaccu gcccgacuuc gagcugcuga gcgccaacac ccuggaggac     1080

agacuggccc accacagaug gcugcuguuc uuccacuucg gcaagaacga gaacagcaac     1140

gaccccgagc ugaagaagcu gaagacccug cugaagaacg accacaucca ggugggcaga     1200

uucgacugca gcagcgcccc cgacaucugc agcaaccugu acguguucca gcccagccug     1260

gccguguuca agggccaggg caccaaggag uacgagaucc accacggcaa gaagauccug     1320

uacgacaucc uggccuucgc caaggagagc gugaacagcc acgugaccac ccugggcccc     1380

cagaacuucc ccgccaacga caaggagccc uggcuggugg acuucuucgc ccccuggugc     1440

ccccccugca gagcccugcu gcccgagcug agaagagcca gcaaccugcu guacggccag     1500

cugaaguucg gcacccugga cugcaccgug cacgagggcc ugugcaacau guacaacauc     1560

caggccuacc ccaccaccgu gguguucaac cagagcaaca uccacgagua cgagggccac     1620

cacagcgccg agcagauccu ggaguucauc gaggaccuga ugaaccccag cguggugagc     1680

cugaccccca ccaccuucaa cgagcuggug acccagagaa agcacaacga gguguggaug     1740

guggacuucu acagccccug gugccacccc ugccaggugc ugaugcccga guggaagaga     1800

auggccagaa cccugaccgg ccugaucaac gugggcagca ucgacugcca gcaguaccac     1860

agcuucugcg cccaggagaa cgugcagaga uaccccgaga ucagauucuu cccccccaag     1920

agcaacaagg ccuaccacua ccacagcuac aacggcugga acagagacgc cuacagccug     1980

agaaucuggg gccugggcuu ccugccccag gugagcaccg accugacccc ccagaccuuc     2040

agcgagaagg ugcugcaggg caagaaccac ugggugaucg acuucuacgc ccccuggugc     2100

ggccccugcc agaacuucgc ccccgaguuc gagcugcugg ccagaaugau caagggcaag     2160

gugaaggccg gcaaggugga cugccaggcc uacgcccaga ccugccagaa ggccggcauc     2220

agagccuacc ccaccgugaa guucuacuuc uacgagagag ccaagagaaa cuuccaggag     2280

gagcagauca acaccagaga cgccaaggcc aucgccgccc ugaucagcga gaagcuggag     2340

acccugagaa accagggcaa gagaaacaag gacgagcugu ga                        2382


<210>  8212
<211>  2382
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC10__Homo_sapiens__BAB55263

<400>  8212
augggcgugu ggcugaacaa ggacgauuac aucagagacc ucaaacggau uauccugugc       60

uuccuuauug ucuauauggc cauccugguu gggaccgauc aggacuuuua cagccuccug      120

ggagugucca agacagcuuc uagccgcgag auuagacaag ccuucaaaaa gcuggcgcuu      180

aaacuccacc ccgauaagaa uccuaacaau ccgaacgcuc auggcgacuu ucugaagauc      240

aaucgggccu augaagugcu gaaagaugag gaccuccgca agaaauacga uaaguauggg      300

gaaaaaggac uggaggacaa ccagggcggg caguacgaau ccuggaauua uuacagauac      360

gauuucggaa ucuaugacga ugaccccgag auuaucacgc uugagcggcg cgaauuugac      420

gccgcuguca acucuggcga gcugugguuc gugaauuuuu acagcccugg cuguucccac      480

ugccaugauc ucgcccccac cuggagagac uucgcuaagg aaguugaugg gcugcuucgg      540

auuggagccg ugaacugugg cgacgaucgc augcugugca gaaugaaggg ggucaauucu      600

uauccuagcc ucuuuaucuu ccgguccgga auggcgcccg ugaaauacca cggcgaccgc      660

agcaaggagu cucugguuuc cuuugccaug cagcauguga gaagcacagu caccgagcug      720

uggacaggga acuucgucaa uucuauucaa accgcuuuug ccgcuggaau cggcuggcuc      780

auuacauucu guuccaaagg cggggauugc cugaccagcc agacgcggcu ucgccugucu      840

ggaaugcucg acggccuggu gaacgugggg uggauggauu gugccaccca ggacaaucuu      900

ugcaaguccc uggauaucac aaccagcaca accgcguauu ucccuccggg agccacgcuc      960

aacaacaaag aaaagaacuc cauccuguuu cucaauucuc uggacgcuaa agagauuuac     1020

cuggaaguua uccacaaucu ucccgacuuc gagcugcuca gcgccaacac acuggaagau     1080

agacuugcuc accaucggug gcugcucuuu uuccacuuug gcaagaauga gaacuccaau     1140

gacccugagc ugaagaaacu gaagacccuc cugaaaaacg aucauauuca gguggggaga     1200

uucgacugua gcucugcccc cgauaucugc uccaaucuuu auguguuuca accuagccug     1260

gccgucuuca agggacaggg cacaaaagaa uacgagauuc accacggcaa gaagauccuc     1320

uacgacaucc uggcuuuugc gaaagaaucu gugaacagcc auguuaccac ccuggggccc     1380

cagaauuucc cggccaacga uaaggagccu uggcuugugg acuuuuucgc ucccuggugu     1440

ccucccugcc gcgcccuccu gcccgaacug cggagagccu ccaaucuccu guauggacag     1500

cuuaaauuug gcacacugga uugcacgguc cacgaggggc ucuguaacau guacaauauu     1560

caggcuuauc cuaccacagu gguuuucaac caaucuaaca uccaugagua cgaaggacac     1620

cauagcgccg agcagauucu ggaguucauc gaagaccuga ugaauccguc cguggucagc     1680

cuuaccccca caaccuuuaa cgaacucgug acgcaacgca agcacaauga ggucuggaug     1740

guggauuucu auucuccuug gugccacccc ugucagguuc ugaugccuga guggaaacgg     1800

auggcgagaa cacugaccgg ccucauuaac guggggucca ucgacugcca gcaguaccau     1860

agcuuuugug cucaagaaaa uguccagcgc uaucccgaga uccgguucuu uccgccuaag     1920

ucuaacaagg ccuaccacua ccauuccuau aauggcugga acagagaugc cuacagccug     1980

cgcauuuggg gacuuggcuu ccugccccag guguccaccg accucacacc ucagaccuuu     2040

ucugaaaaag uucugcaagg gaagaaucac ugggugaucg acuucuaugc ucccuggugc     2100

ggaccuuguc agaacuuugc ccccgaguuc gagcugcuug cucggaugau uaaaggcaag     2160

gucaaagccg ggaaggugga uugccaggcg uacgcccaga caugucaaaa ggcuggaauc     2220

agagccuauc cgacggugaa auuuuacuuc uaugaacgcg cuaagcggaa uuuucaggag     2280

gaacagauua acaccagaga cgccaaagcg aucgccgcuc ucauuagcga gaagcuggaa     2340

acacugcgga aucagggcaa acgcaacaag gaugagcucu ga                        2382


<210>  8213
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC12__Homo_sapiens__Q9UKB3

<400>  8213

Met Asp Ala Ile Leu Asn Tyr Arg Ser Glu Asp Thr Glu Asp Tyr Tyr 
1               5                   10                  15      


Thr Leu Leu Gly Cys Asp Glu Leu Ser Ser Val Glu Gln Ile Leu Ala 
            20                  25                  30          


Glu Phe Lys Val Arg Ala Leu Glu Cys His Pro Asp Lys His Pro Glu 
        35                  40                  45              


Asn Pro Lys Ala Val Glu Thr Phe Gln Lys Leu Gln Lys Ala Lys Glu 
    50                  55                  60                  


Ile Leu Thr Asn Glu Glu Ser Arg Ala Arg Tyr Asp His Trp Arg Arg 
65                  70                  75                  80  


Ser Gln Met Ser Met Pro Phe Gln Gln Trp Glu Ala Leu Asn Asp Ser 
                85                  90                  95      


Val Lys Thr Ser Met His Trp Val Val Arg Gly Lys Lys Asp Leu Met 
            100                 105                 110         


Leu Glu Glu Ser Asp Lys Thr His Thr Thr Lys Met Glu Asn Glu Glu 
        115                 120                 125             


Cys Asn Glu Gln Arg Glu Arg Lys Lys Glu Glu Leu Ala Ser Thr Ala 
    130                 135                 140                 


Glu Lys Thr Glu Gln Lys Glu Pro Lys Pro Leu Glu Lys Ser Val Ser 
145                 150                 155                 160 


Pro Gln Asn Ser Asp Ser Ser Gly Phe Ala Asp Val Asn Gly Trp His 
                165                 170                 175     


Leu Arg Phe Arg Trp Ser Lys Asp Ala Pro Ser Glu Leu Leu Arg Lys 
            180                 185                 190         


Phe Arg Asn Tyr Glu Ile 
        195             


<210>  8214
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC12__Homo_sapiens__AAD52650

<400>  8214
auggaugcaa uacugaauua caggucagaa gauacugaag auuacuacac auuacuggga       60

ugugaugaac uaucuucggu ugaacaaauc cuggcagaau uuaaagucag agcucuggaa      120

ugucacccag acaagcaucc ugaaaacccc aaagcugugg agacuuuuca gaaacugcag      180

aaggcaaagg agauucugac caaugaagag agucgagccc gcuaugacca cuggcgaagg      240

agccagaugu cgaugccauu ccagcagugg gaagcuuuga augacucagu gaagacguca      300

augcacuggg uugucagagg uaaaaaagac cugaugcugg aagaaucuga caagacucau      360

accaccaaga uggaaaauga ggaauguaau gagcaaagag aaagaaagaa agaggagcug      420

gcuucaaccg cagagaaaac ggagcagaaa gaacccaagc cccuagagaa gucagucucc      480

ccgcaaaauu cagauucuuc agguuuugca gaugugaaug guuggcaccu ucguuuccgc      540

ugguccaagg augcucccuc agaacuccug aggaaguuca gaaacuauga aauauga         597


<210>  8215
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC12__Homo_sapiens__AAD52650

<400>  8215
auggacgcca uccugaacua ccgcagcgag gacaccgagg acuacuacac ccuccugggc       60

ugcgacgagc uguccagcgu ggagcagauc cucgccgagu ucaagguccg ggcgcuggag      120

ugccaccccg acaagcaccc ggagaacccc aaggccgugg agacguucca gaagcugcag      180

aaggccaagg agauccucac caacgaggag ucccgcgccc gguacgacca cuggcgccgg      240

agccagaugu ccaugcccuu ccagcagugg gaggcccuga acgacagcgu gaagaccucc      300

augcacuggg ucgugcgcgg gaagaaggac cugaugcucg aggagagcga caagacccac      360

acgaccaaga uggagaacga ggagugcaac gagcagcggg agcgcaagaa ggaggagcug      420

gcguccaccg ccgagaagac cgagcagaag gagcccaagc cgcuggagaa guccgugagc      480

ccccagaaca gcgacuccag cggcuucgcc gacgucaacg gguggcaccu ccgguuccgc      540

ugguccaagg acgcccccag cgagcugcug cggaaguucc gcaacuacga gaucuga         597


<210>  8216
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC12__Homo_sapiens__AAD52650

<400>  8216
auggacgcca uccucaacua ccgcuccgag gacaccgagg acuacuacac ccuccucggc       60

ugcgacgagc ucuccuccgu cgagcagauc cucgccgagu ucaagguccg cgcccucgag      120

ugccaccccg acaagcaccc cgagaacccc aaggccgucg agaccuucca gaagcuccag      180

aaggccaagg agauccucac caacgaggag ucccgcgccc gcuacgacca cuggcgccgc      240

ucccagaugu ccaugcccuu ccagcagugg gaggcccuca acgacuccgu caagaccucc      300

augcacuggg ucguccgcgg caagaaggac cucaugcucg aggaguccga caagacccac      360

accaccaaga uggagaacga ggagugcaac gagcagcgcg agcgcaagaa ggaggagcuc      420

gccuccaccg ccgagaagac cgagcagaag gagcccaagc cccucgagaa guccgucucc      480

ccccagaacu ccgacuccuc cggcuucgcc gacgucaacg gcuggcaccu ccgcuuccgc      540

ugguccaagg acgcccccuc cgagcuccuc cgcaaguucc gcaacuacga gaucuga         597


<210>  8217
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC12__Homo_sapiens__AAD52650

<400>  8217
auggacgcca uccugaacua cagaagcgag gauaccgaag acuauuacac acuccuuggc       60

ugcgaugagc uguccucugu ggaacagauu uuggcugagu ucaaggucag ggcauuagaa      120

ugucaccccg acaaacaucc ugagaaucca aaggccguug agacuuuuca aaaacugcag      180

aaggcgaaag aaauacuaac gaacgaggaa ucacgggcuc gcuaugauca cuggcgacgu      240

agucagauga gcaugccguu ccagcaaugg gaggcccuca augacuccgu gaagaccucu      300

augcauuggg uagugagagg gaagaaagau cugaugcuug aggaaucgga caagacacac      360

acuaccaaaa uggagaacga agagugcaau gaacagaggg agcggaagaa agaggaacug      420

gcaucaacag ccgagaagac cgaacagaag gagcccaaac cuuuggaaaa gagcgucagu      480

ccacagaacu ccgauucuag cggauuugcu gacgugaaug guuggcaucu ccgcuucaga      540

ugguccaaag augcacccuc agagcugcug aggaaguuuc ggaacuacga gaucuga         597


<210>  8218
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC12__Homo_sapiens__AAD52650

<400>  8218
auggacgcca uccugaacua cagaagcgag gacaccgagg acuacuacac ccugcugggc       60

ugcgacgagc ugagcagcgu ggagcagauc cuggccgagu ucaaggugag agcccuggag      120

ugccaccccg acaagcaccc cgagaacccc aaggccgugg agaccuucca gaagcugcag      180

aaggccaagg agauccugac caacgaggag agcagagcca gauacgacca cuggagaaga      240

agccagauga gcaugcccuu ccagcagugg gaggcccuga acgacagcgu gaagaccagc      300

augcacuggg uggugagagg caagaaggac cugaugcugg aggagagcga caagacccac      360

accaccaaga uggagaacga ggagugcaac gagcagagag agagaaagaa ggaggagcug      420

gccagcaccg ccgagaagac cgagcagaag gagcccaagc cccuggagaa gagcgugagc      480

ccccagaaca gcgacagcag cggcuucgcc gacgugaacg gcuggcaccu gagauucaga      540

uggagcaagg acgcccccag cgagcugcug agaaaguuca gaaacuacga gaucuga         597


<210>  8219
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC12__Homo_sapiens__AAD52650

<400>  8219
auggacgcca uccugaacua cagaagcgag gauaccgaag acuauuacac acuccugggc       60

ugcgaugagc uuuccucugu ggaacagauu cuggcugagu ucaagguccg ggcccucgaa      120

ugucaccccg acaaacaucc ugagaauccg aaggcgguug agacguuuca aaaacugcag      180

aaggcuaaag aaauccuuac caacgaggaa agccgcgcca gauaugauca cuggcggcgc      240

ucccagaugu cuaugcccuu ccagcaaugg gaggcccuga augacagcgu gaagacaucc      300

augcauuggg uggucagagg gaagaaagau cucaugcugg aggaaucuga caagacccac      360

acaaccaaaa uggagaacga agagugcaau gaacagcggg agcgcaagaa agaggaacug      420

gcuagcacag ccgagaagac cgaacagaag gagccuaaac cccucgaaaa guccgugagc      480

ccucagaacu cugauuccag cggauuugcu gacguuaaug gcuggcaucu gagauuccgg      540

uggucuaaag augcccccuc cgagcuucug cgcaaguuua gaaacuacga gauuuga         597


<210>  8220
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC14__Homo_sapiens__Q6Y2X3

<400>  8220

Met Ala Gln Lys His Pro Gly Glu Arg Gly Leu Tyr Gly Ala His His 
1               5                   10                  15      


Ser Gly Gly Ala Ser Leu Arg Thr Leu Gly Pro Ser Val Asp Pro Glu 
            20                  25                  30          


Ile Pro Ser Phe Ser Gly Leu Arg Asp Ser Ala Gly Thr Ala Pro Asn 
        35                  40                  45              


Gly Thr Arg Cys Leu Thr Glu His Ser Gly Pro Lys His Thr Gln His 
    50                  55                  60                  


Pro Asn Pro Ala His Trp Leu Asp Pro Ser His Gly Pro Pro Gly Gly 
65                  70                  75                  80  


Pro Gly Pro Pro Arg Asp Ala Glu Asp Pro Asp Gln Ser Glu Thr Ser 
                85                  90                  95      


Ser Glu Glu Glu Ser Gly Val Asp Gln Glu Leu Ser Lys Glu Asn Glu 
            100                 105                 110         


Thr Gly Asn Gln Lys Asp Gly Asn Ser Phe Leu Ser Ile Pro Ser Ala 
        115                 120                 125             


Cys Asn Cys Gln Gly Thr Pro Gly Ile Pro Glu Gly Pro Tyr Ser Glu 
    130                 135                 140                 


Gly Gly Asn Gly Ser Ser Ser Asn Phe Cys His His Cys Thr Ser Pro 
145                 150                 155                 160 


Ala Leu Gly Glu Asp Glu Leu Glu Glu Glu Tyr Asp Asp Glu Glu Ser 
                165                 170                 175     


Leu Lys Phe Pro Ser Asp Phe Ser Arg Val Ser Ser Gly Lys Lys Pro 
            180                 185                 190         


Pro Ser Arg Arg Gln Arg His Arg Phe Pro Thr Lys Glu Asp Thr Arg 
        195                 200                 205             


Glu Gly Gly Arg Arg Asp Pro Arg Ser Pro Gly Arg His Arg Leu Gly 
    210                 215                 220                 


Arg Lys Arg Ser Gln Ala Asp Lys Arg Lys Gly Leu Gly Leu Trp Gly 
225                 230                 235                 240 


Ala Glu Glu Leu Cys Gln Leu Gly Gln Ala Gly Phe Trp Trp Leu Ile 
                245                 250                 255     


Glu Leu Leu Val Leu Val Gly Glu Tyr Val Glu Thr Cys Gly His Leu 
            260                 265                 270         


Ile Tyr Ala Cys Arg Gln Leu Lys Ser Ser Asp Leu Asp Leu Phe Arg 
        275                 280                 285             


Val Trp Met Gly Val Trp Thr Gly Arg Leu Gly Gly Trp Ala Gln Val 
    290                 295                 300                 


Met Phe Gln Phe Leu Ser Gln Gly Phe Tyr Cys Gly Val Gly Leu Phe 
305                 310                 315                 320 


Thr Arg Phe Leu Lys Leu Leu Gly Ala Leu Leu Leu Leu Ala Leu Ala 
                325                 330                 335     


Leu Phe Leu Gly Phe Leu Gln Leu Gly Trp Arg Phe Leu Val Gly Leu 
            340                 345                 350         


Gly Asp Arg Leu Gly Trp Arg Asp Lys Ala Thr Trp Leu Phe Ser Trp 
        355                 360                 365             


Leu Asp Ser Pro Ala Leu Gln Arg Cys Leu Thr Leu Leu Arg Asp Ser 
    370                 375                 380                 


Arg Pro Trp Gln Arg Leu Val Arg Ile Val Gln Trp Gly Trp Leu Glu 
385                 390                 395                 400 


Leu Pro Trp Val Lys Gln Asn Ile Asn Arg Gln Gly Asn Ala Pro Val 
                405                 410                 415     


Ala Ser Gly Arg Tyr Cys Gln Pro Glu Glu Glu Val Ala Arg Leu Leu 
            420                 425                 430         


Thr Met Ala Gly Val Pro Glu Asp Glu Leu Asn Pro Phe His Val Leu 
        435                 440                 445             


Gly Val Glu Ala Thr Ala Ser Asp Val Glu Leu Lys Lys Ala Tyr Arg 
    450                 455                 460                 


Gln Leu Ala Val Met Val His Pro Asp Lys Asn His His Pro Arg Ala 
465                 470                 475                 480 


Glu Glu Ala Phe Lys Val Leu Arg Ala Ala Trp Asp Ile Val Ser Asn 
                485                 490                 495     


Ala Glu Lys Arg Lys Glu Tyr Glu Met Lys Arg Met Ala Glu Asn Glu 
            500                 505                 510         


Leu Ser Arg Ser Val Asn Glu Phe Leu Ser Lys Leu Gln Asp Asp Leu 
        515                 520                 525             


Lys Glu Ala Met Asn Thr Met Met Cys Ser Arg Cys Gln Gly Lys His 
    530                 535                 540                 


Arg Arg Phe Glu Met Asp Arg Glu Pro Lys Ser Ala Arg Tyr Cys Ala 
545                 550                 555                 560 


Glu Cys Asn Arg Leu His Pro Ala Glu Glu Gly Asp Phe Trp Ala Glu 
                565                 570                 575     


Ser Ser Met Leu Gly Leu Lys Ile Thr Tyr Phe Ala Leu Met Asp Gly 
            580                 585                 590         


Lys Val Tyr Asp Ile Thr Glu Trp Ala Gly Cys Gln Arg Val Gly Ile 
        595                 600                 605             


Ser Pro Asp Thr His Arg Val Pro Tyr His Ile Ser Phe Gly Ser Arg 
    610                 615                 620                 


Ile Pro Gly Thr Arg Gly Arg Gln Arg Ala Thr Pro Asp Ala Pro Pro 
625                 630                 635                 640 


Ala Asp Leu Gln Asp Phe Leu Ser Arg Ile Phe Gln Val Pro Pro Gly 
                645                 650                 655     


Gln Met Pro Asn Gly Asn Phe Phe Ala Ala Pro Gln Pro Ala Pro Gly 
            660                 665                 670         


Ala Ala Ala Ala Ser Lys Pro Asn Ser Thr Val Pro Lys Gly Glu Ala 
        675                 680                 685             


Lys Pro Lys Arg Arg Lys Lys Val Arg Arg Pro Phe Gln Arg 
    690                 695                 700         


<210>  8221
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC14__Homo_sapiens__AAI17147

<400>  8221
auggcccaga agcaccccgg agaaagaggg uuguauggag cccaccacag ugguggugcc       60

ucccucagga cuuuaggacc cuccguggac ccugaaauac cuucauucuc aggacucagg      120

gacucagcag ggacugcucc uaaugguacc cgcugccuca cagagcacuc ugguccuaag      180

cacacacagc acccaaaccc agcccauugg uuggacccaa gccauggccc cccagggggu      240

ccaggaccac cuagagaugc agaggacccu gaucagagug agacgucuuc agaagaagaa      300

ucaggagugg accaggaacu cucaaaagaa aacgagacug ggaaccagaa ggaugggaac      360

ucuuuucuuu ccauuccauc ugcuugcaac ugccagggaa caccuggaau uccagaaggg      420

ccuuacucug agggaggaaa ugguucuucu agcaacuuuu gccaccacug uaccucucca      480

gcuuuggggg aagaugaguu ggaagaggaa uaugaugaug aagaaucucu caaguucccc      540

agugauuuuu cgcguguguc cagcggaaag aaacccccau cccggagaca gcggcaccgc      600

uuuccaacga aggaggauac ucgggagggu ggacguaggg aucccagguc cccuggucga      660

caucggcugg gucggaaacg aagucaggca gauaagcgca aaggccuggg auugugggga      720

gccgaggaac uaugucaacu uggacaggca ggcuuuuggu ggcugauuga acugcuggua      780

uuggugggag aguacguaga aacuuguggc caucucaucu augccugcag gcaacugaaa      840

agcagugauu uggaccuuuu ucgaguuugg augggagugu ggacagggcg guuagggggc      900

ugggcccagg ucauguuuca guuucuaagc cagggguuuu acuguggagu aggacuguuu      960

acucguuuuc uuaagcugcu gggugcuuug cugcuccugg cucuggcccu cuuuuugggc     1020

uuucuacagu ugggauggcg guuucuggug ggacuaggug accgguuagg cuggagggau     1080

aaggcuaccu ggcucuucuc uuggcuggau ucuccagccu ugcagcguug cuugacucug     1140

cugagagaua gcaggccaug gcagcggcug guaagaauag uucagugggg cuggcuggag     1200

uugccuuggg ucaagcagaa uauuaauagg caggggaaug caccuguagc uagugggcgc     1260

uacugccagc cugaagagga aguggcucga cucuugacca uggcuggggu uccugaggau     1320

gagcuaaacc cuuuccaugu acuggggguu gaggccacag caucagaugu ugaacugaag     1380

aaggccuaua gacagcuggc agugaugguu cauccugaca aaaaucauca uccccgggcu     1440

gaggaggccu ucaagguuuu gcgagcagcu ugggacauug ucagcaaugc ugaaaagcga     1500

aaggaguaug agaugaaacg aauggcagag aaugagcuga gccggucagu aaaugaguuu     1560

cuguccaagc ugcaagauga ccucaaggag gcaaugaaua cuaugaugug uagccgaugc     1620

caaggaaagc auaggagguu ugaaauggac cgggaaccua agagugccag auacugugcu     1680

gaguguaaua ggcugcaucc ugcugaggaa ggagacuuuu gggcagaguc aagcauguug     1740

ggccucaaga ucaccuacuu ugcacugaug gauggaaagg uguaugacau cacagagugg     1800

gcuggaugcc agcguguagg uaucucccca gauacccaca gaguccccua ucacaucuca     1860

uuugguucuc ggauuccagg caccagaggg cggcagagag ccaccccaga ugccccuccu     1920

gcugaucuuc aggauuucuu gagucggauc uuucaaguac ccccagggca gaugcccaau     1980

gggaacuucu uugcagcucc ucagccugcc ccuggagccg cugcagccuc uaagcccaac     2040

agcacaguac ccaagggaga agccaaaccu aagcggcgga agaaagugag gaggcccuuc     2100

caacguuga                                                             2109


<210>  8222
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC14__Homo_sapiens__AAI17147

<400>  8222
auggcccaga agcaccccgg cgagcgcggg cuguacggcg cccaccacag cgggggcgcg       60

ucccuccgga cccuggggcc gagcguggac cccgagaucc ccuccuucag cggccugcgc      120

gacuccgccg gcaccgcccc caacgggacg cggugccuca ccgagcacag cggcccgaag      180

cacacccagc accccaaccc cgcccacugg cuggaccccu cccacgggcc gcccggcggg      240

cccgggcccc cgcgcgacgc cgaggacccc gaccagagcg agaccuccag cgaggaggag      300

uccggcgucg accaggagcu gagcaaggag aacgagacgg ggaaccagaa ggacggcaac      360

uccuuccuca gcauccccuc cgcgugcaac ugccagggga cccccggcau cccggagggc      420

cccuacagcg agggcggcaa cggguccagc uccaacuucu gccaccacug caccagcccc      480

gcccugggcg aggacgagcu ggaggaggag uacgacgacg aggagagccu caaguucccc      540

uccgacuuca gccggguguc cagcgggaag aagccgcccu cccgccggca gcgccaccgg      600

uuccccacca aggaggacac gcgcgagggc ggccggcgcg acccccggag cccggggcgc      660

caccggcugg gccgcaagcg gucccaggcc gacaagcgca aggggcuggg ccucuggggc      720

gccgaggagc ugugccagcu ggggcaggcg ggcuucuggu ggcucaucga gcugcuggug      780

cucgucgggg aguacgugga gaccugcggc caccugaucu acgccugccg gcagcucaag      840

agcuccgacc uggaccuguu ccgcgugugg augggggucu ggaccggccg gcucgggggc      900

ugggcccagg ugauguucca guuccugagc cagggcuucu acugcggggu gggccuguuc      960

acccgcuucc ugaagcuccu gggggcccug cuccugcugg cccucgcgcu guuccugggc     1020

uuccuccagc ugggcuggcg cuuccugguc gggcucggcg accggcuggg guggcgcgac     1080

aaggccacgu ggcuguucuc cuggcucgac agccccgccc ugcagcggug ccugacccuc     1140

cugcgcgacu cccggcccug gcagcgccug gugcggaucg ugcagugggg cuggcucgag     1200

cugcccuggg ucaagcagaa caucaaccgc caggggaacg ccccgguggc cagcggccgg     1260

uacugccagc ccgaggagga gguggcgcgc cugcugacca uggccggcgu ccccgaggac     1320

gagcucaacc cguuccacgu gcugggggug gaggccaccg ccuccgacgu cgagcugaag     1380

aaggccuacc ggcagcucgc ggugauggug caccccgaca agaaccacca cccccgcgcc     1440

gaggaggccu ucaagguccu gcgggccgcc ugggacaucg ugagcaacgc ggagaagcgc     1500

aaggaguacg agaugaagcg gauggccgag aacgagcugu cccgcagcgu gaacgaguuc     1560

cucuccaagc ugcaggacga ccugaaggag gccaugaaca cgaugaugug cagccggugc     1620

cagggcaagc accgccgguu cgagauggac cgcgagccca agagcgcccg cuacugcgcg     1680

gagugcaacc ggcuccaccc ggccgaggag ggggacuucu gggccgaguc cagcaugcug     1740

ggccugaaga ucaccuacuu cgcccucaug gacgggaagg ucuacgacau caccgagugg     1800

gccggcugcc agcgcguggg caucuccccc gacacccacc ggguccccua ccacaucagc     1860

uucggguccc gcauccccgg cacgcggggg cgccagcggg cgaccccgga cgccccgccc     1920

gccgaccugc aggacuuccu gagccgcauc uuccaggugc cgcccggcca gaugcccaac     1980

gggaacuucu ucgccgcgcc ccagcccgcc cccggcgccg ccgccgccuc caagcccaac     2040

agcaccgugc ccaagggcga ggcgaagccc aagcggcgca agaagguccg gcgcccguuc     2100

cagcgguga                                                             2109


<210>  8223
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC14__Homo_sapiens__AAI17147

<400>  8223
auggcccaga agcaccccgg cgagcgcggc cucuacggcg cccaccacuc cggcggcgcc       60

ucccuccgca cccucggccc cuccgucgac cccgagaucc ccuccuucuc cggccuccgc      120

gacuccgccg gcaccgcccc caacggcacc cgcugccuca ccgagcacuc cggccccaag      180

cacacccagc accccaaccc cgcccacugg cucgaccccu cccacggccc ccccggcggc      240

cccggccccc cccgcgacgc cgaggacccc gaccaguccg agaccuccuc cgaggaggag      300

uccggcgucg accaggagcu cuccaaggag aacgagaccg gcaaccagaa ggacggcaac      360

uccuuccucu ccauccccuc cgccugcaac ugccagggca cccccggcau ccccgagggc      420

cccuacuccg agggcggcaa cggcuccucc uccaacuucu gccaccacug caccuccccc      480

gcccucggcg aggacgagcu cgaggaggag uacgacgacg aggagucccu caaguucccc      540

uccgacuucu cccgcgucuc cuccggcaag aagccccccu cccgccgcca gcgccaccgc      600

uuccccacca aggaggacac ccgcgagggc ggccgccgcg acccccgcuc ccccggccgc      660

caccgccucg gccgcaagcg cucccaggcc gacaagcgca agggccucgg ccucuggggc      720

gccgaggagc ucugccagcu cggccaggcc ggcuucuggu ggcucaucga gcuccucguc      780

cucgucggcg aguacgucga gaccugcggc caccucaucu acgccugccg ccagcucaag      840

uccuccgacc ucgaccucuu ccgcgucugg augggcgucu ggaccggccg ccucggcggc      900

ugggcccagg ucauguucca guuccucucc cagggcuucu acugcggcgu cggccucuuc      960

acccgcuucc ucaagcuccu cggcgcccuc cuccuccucg cccucgcccu cuuccucggc     1020

uuccuccagc ucggcuggcg cuuccucguc ggccucggcg accgccucgg cuggcgcgac     1080

aaggccaccu ggcucuucuc cuggcucgac ucccccgccc uccagcgcug ccucacccuc     1140

cuccgcgacu cccgccccug gcagcgccuc guccgcaucg uccagugggg cuggcucgag     1200

cuccccuggg ucaagcagaa caucaaccgc cagggcaacg cccccgucgc cuccggccgc     1260

uacugccagc ccgaggagga ggucgcccgc cuccucacca uggccggcgu ccccgaggac     1320

gagcucaacc ccuuccacgu ccucggcguc gaggccaccg ccuccgacgu cgagcucaag     1380

aaggccuacc gccagcucgc cgucaugguc caccccgaca agaaccacca cccccgcgcc     1440

gaggaggccu ucaagguccu ccgcgccgcc ugggacaucg ucuccaacgc cgagaagcgc     1500

aaggaguacg agaugaagcg cauggccgag aacgagcucu cccgcuccgu caacgaguuc     1560

cucuccaagc uccaggacga ccucaaggag gccaugaaca ccaugaugug cucccgcugc     1620

cagggcaagc accgccgcuu cgagauggac cgcgagccca aguccgcccg cuacugcgcc     1680

gagugcaacc gccuccaccc cgccgaggag ggcgacuucu gggccgaguc cuccaugcuc     1740

ggccucaaga ucaccuacuu cgcccucaug gacggcaagg ucuacgacau caccgagugg     1800

gccggcugcc agcgcgucgg caucuccccc gacacccacc gcguccccua ccacaucucc     1860

uucggcuccc gcauccccgg cacccgcggc cgccagcgcg ccacccccga cgcccccccc     1920

gccgaccucc aggacuuccu cucccgcauc uuccaggucc cccccggcca gaugcccaac     1980

ggcaacuucu ucgccgcccc ccagcccgcc cccggcgccg ccgccgccuc caagcccaac     2040

uccaccgucc ccaagggcga ggccaagccc aagcgccgca agaagguccg ccgccccuuc     2100

cagcgcuga                                                             2109


<210>  8224
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC14__Homo_sapiens__AAI17147

<400>  8224
auggcccaga agcaccccgg cgagagaggg cuguacggag cucaucacag cgguggcgca       60

ucccucagga cccuugggcc uucuguggac ccagaaaucc cgucauucag uggacugcgg      120

gauagcgccg gcacagcgcc caacgguacu cgcugcuuga cggagcauuc cgggccuaaa      180

cacacccaac auccaaaucc cgcucacugg uuagacccuu cucacggacc acccggcggc      240

ccugggccac cgcgagaugc cgaagacccc gaucagucgg agacaucaag cgaagaggag      300

aguggagucg accaggaacu guccaaggag aacgaaacug guaaucagaa agauggcaac      360

ucuuuucuaa gcauuccuuc cgcauguaau ugccaaggga ccccaggaau acccgagggc      420

ccuuauucag agggugggaa cggaaguagc ucuaauuucu gucaucacug cacaucccca      480

gcccucggcg aagacgagcu ggaagaggaa uacgaugacg aggagucacu uaaguuuccc      540

agcgauuuca gucguguuuc uuccggcaaa aagccgccua gcagaaggca gcggcaucgc      600

uuucccacca aggaagacac uagagaaggg ggaaggcggg auccacgcuc gccuggucga      660

cacagacugg gcaggaaacg gucucaggcu gacaagcgua aaggguuggg acucuggggc      720

gcagaggagc ugugucagcu gggucaagcc ggguucuggu ggcucaucga auuacuggug      780

cuuguaggcg aguaugugga gacaugcgga cacuugauuu acgcuugucg ccagcugaag      840

uccucagacc uagaucucuu uagagucugg augggcgugu ggaccgggag gcugggaggu      900

ugggcccagg uuauguucca guuucuuagu caaggcuucu auugcggggu gggacuguuu      960

acgcgguucu ugaaacuccu gggcgcguua cugcuccuug cacuggccuu guuucuaggu     1020

uuccugcagc ucggguggcg auuccugguc ggccuuggag accgccuggg cuggagagau     1080

aaggcuacuu gguuguuuag cuggcucgac ucccccgccc ugcagaggug uuuaacccug     1140

cuacgggauu cucgcccaug gcaaagacuc gugaggaucg uacagugggg guggcuggaa     1200

cuucccuggg uuaagcagaa cauuaaucgu cagggaaacg caccuguggc uagcggucgg     1260

uacugccaac cagaggaaga ggucgcccga uugcugacaa uggcgggcgu gccggaagac     1320

gagcucaauc ccuuccaugu gcuggggguc gaggccacug caucagaugu ugaacuuaaa     1380

aaggcuuaua gacagcuggc cgugauggua cacccugaca aaaaccauca cccaagggcu     1440

gaggaagccu uuaagguguu gcgcgcagcc ugggauaucg ucaguaaugc ugagaaacgg     1500

aaggaguacg aaaugaaaag aauggcggag aacgaacucu ccaggagcgu gaaugaguuc     1560

cugucuaagu uacaggacga ucugaaggaa gcaaugaaca ccaugaugug uucacgcugc     1620

cagggaaaac aucgacgguu ugagauggac cgugagccca agagugccag auacugcgcu     1680

gaauguaaca ggcuacaccc ugccgaggaa ggcgacuucu gggcagagag cuccaugcuc     1740

ggucugaaaa uaacauauuu ugcccuuaug gaugggaagg uuuacgacau caccgaaugg     1800

gcuggcugcc aacgcguggg aauuucucca gauacgcacc ggguccccua ucauaucucg     1860

uucggcagca ggauuccggg gacuagagga cgacagcgcg ccacaccuga cgcaccaccc     1920

gcggauuugc aggacuuucu gucccggauc uuccaggugc cucccggcca aaugccaaau     1980

gguaacuuuu ucgcugcccc ucagcccgca ccaggggccg cugccgcauc aaaaccgaau     2040

aguaccguac cuaagggaga ggcuaagccc aaaagaagga agaaaguucg ucgcccauuu     2100

cagcgguga                                                             2109


<210>  8225
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC14__Homo_sapiens__AAI17147

<400>  8225
auggcccaga agcaccccgg cgagagaggc cuguacggcg cccaccacag cggcggcgcc       60

agccugagaa cccugggccc cagcguggac cccgagaucc ccagcuucag cggccugaga      120

gacagcgccg gcaccgcccc caacggcacc agaugccuga ccgagcacag cggccccaag      180

cacacccagc accccaaccc cgcccacugg cuggacccca gccacggccc ccccggcggc      240

cccggccccc ccagagacgc cgaggacccc gaccagagcg agaccagcag cgaggaggag      300

agcggcgugg accaggagcu gagcaaggag aacgagaccg gcaaccagaa ggacggcaac      360

agcuuccuga gcauccccag cgccugcaac ugccagggca cccccggcau ccccgagggc      420

cccuacagcg agggcggcaa cggcagcagc agcaacuucu gccaccacug caccagcccc      480

gcccugggcg aggacgagcu ggaggaggag uacgacgacg aggagagccu gaaguucccc      540

agcgacuuca gcagagugag cagcggcaag aagcccccca gcagaagaca gagacacaga      600

uuccccacca aggaggacac cagagagggc ggcagaagag accccagaag ccccggcaga      660

cacagacugg gcagaaagag aagccaggcc gacaagagaa agggccuggg ccuguggggc      720

gccgaggagc ugugccagcu gggccaggcc ggcuucuggu ggcugaucga gcugcuggug      780

cuggugggcg aguacgugga gaccugcggc caccugaucu acgccugcag acagcugaag      840

agcagcgacc uggaccuguu cagagugugg augggcgugu ggaccggcag acugggcggc      900

ugggcccagg ugauguucca guuccugagc cagggcuucu acugcggcgu gggccuguuc      960

accagauucc ugaagcugcu gggcgcccug cugcugcugg cccuggcccu guuccugggc     1020

uuccugcagc ugggcuggag auuccuggug ggccugggcg acagacuggg cuggagagac     1080

aaggccaccu ggcuguucag cuggcuggac agccccgccc ugcagagaug ccugacccug     1140

cugagagaca gcagacccug gcagagacug gugagaaucg ugcagugggg cuggcuggag     1200

cugcccuggg ugaagcagaa caucaacaga cagggcaacg cccccguggc cagcggcaga     1260

uacugccagc ccgaggagga gguggccaga cugcugacca uggccggcgu gcccgaggac     1320

gagcugaacc ccuuccacgu gcugggcgug gaggccaccg ccagcgacgu ggagcugaag     1380

aaggccuaca gacagcuggc cgugauggug caccccgaca agaaccacca ccccagagcc     1440

gaggaggccu ucaaggugcu gagagccgcc ugggacaucg ugagcaacgc cgagaagaga     1500

aaggaguacg agaugaagag aauggccgag aacgagcuga gcagaagcgu gaacgaguuc     1560

cugagcaagc ugcaggacga ccugaaggag gccaugaaca ccaugaugug cagcagaugc     1620

cagggcaagc acagaagauu cgagauggac agagagccca agagcgccag auacugcgcc     1680

gagugcaaca gacugcaccc cgccgaggag ggcgacuucu gggccgagag cagcaugcug     1740

ggccugaaga ucaccuacuu cgcccugaug gacggcaagg uguacgacau caccgagugg     1800

gccggcugcc agagaguggg caucagcccc gacacccaca gagugcccua ccacaucagc     1860

uucggcagca gaauccccgg caccagaggc agacagagag ccacccccga cgcccccccc     1920

gccgaccugc aggacuuccu gagcagaauc uuccaggugc cccccggcca gaugcccaac     1980

ggcaacuucu ucgccgcccc ccagcccgcc cccggcgccg ccgccgccag caagcccaac     2040

agcaccgugc ccaagggcga ggccaagccc aagagaagaa agaaggugag aagacccuuc     2100

cagagauga                                                             2109


<210>  8226
<211>  2109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC14__Homo_sapiens__AAI17147

<400>  8226
auggcccaga agcaccccgg cgagagaggg cuguacggag cucaucacag cggcggggcc       60

ucccuccgga cccugggacc uucuguggac ccggaaaucc ccagcuucuc cggccuucgc      120

gauucugcgg ggacagcucc uaacggaacg agaugccuga ccgagcauag cggccccaaa      180

cacacacaac auccuaaucc cgcccacugg cucgacccuu cccacggccc gcccggggga      240

ccugggcccc cucgggaugc cgaagacccc gaucagucug agaccagcuc cgaagaggag      300

agcggggucg accaggaacu gucuaaggag aacgaaacag gaaaucagaa agauggcaac      360

uccuuucuua gcauuccguc ugcuuguaau ugccaaggga ccccuggaau ccccgagggc      420

ccuuauuccg agggcgggaa cggaucuagc uccaauuucu gucaucacug cacaagcccc      480

gcccugggcg aagacgagcu cgaagaggaa uacgaugacg aggagucccu gaaguuuccc      540

ucugauuuca gccgcguuuc cagcgggaaa aagccuccgu cuagacggca gcgccauaga      600

uuucccacca aggaagacac gcgggaggga ggccgcagag auccucgguc ccccgggcgc      660

cacagacugg gacggaaacg cagccaggcu gacaagagaa aaggccucgg ccuguggggc      720

gccgaggaac uuugucagcu gggacaagcg ggcuucuggu ggcucauuga acugcuugug      780

cugguggggg aguaugucga gaccugcgga caccucaucu acgccugucg gcagcugaag      840

ucuagcgacc uggaucucuu uagagugugg augggcguuu ggacagggcg ccugggcgga      900

ugggcucagg ugauguucca guuucuuucc caaggcuucu auugcggggu cggacuguuu      960

acccgguucc ucaaacugcu uggcgcccug cuccugcugg cucucgcccu guuucuuggg     1020

uuccugcagc ucggauggag auuccuggug ggccuugggg accgccuggg cuggcgggau     1080

aaggcgacau ggcucuuuuc uuggcuggac agcccugccc ugcagagaug ucucacccug     1140

cuucgcgauu cccggcccug gcaaagacug guucgcauug ugcagugggg auggcucgaa     1200

cugccguggg ucaagcagaa caucaaucgg cagggcaacg cuccuguggc cagcgggaga     1260

uacugccaac ccgaggaaga gguggcucgc cugcuuacga uggccggagu cccugaagac     1320

gagcucaauc ccuuccaugu ucugggcgug gaggccacag cuucugaugu ggaacugaaa     1380

aaggcguauc ggcagcucgc cgucauggug cacccugaca aaaaccauca ccccagagcu     1440

gaggaagccu uuaagguucu gcgggccgcu ugggauaucg uguccaaugc cgagaaacgc     1500

aaggaguacg aaaugaaaag aauggcggag aacgaacuua gccggucugu caaugaguuc     1560

cuguccaagc uccaggacga ucugaaggaa gcuaugaaca ccaugaugug uagcagaugc     1620

caggggaaac aucgccgguu ugagauggac agagagccga aguccgcccg cuacugcgcc     1680

gaauguaaca gacugcaccc ugcugaggaa ggagacuucu gggccgaguc uagcaugcuu     1740

ggccucaaaa uuacauauuu ugcucugaug gaugggaagg uguacgacau caccgaaugg     1800

gccggcugcc aacggguugg aauuuccccc gauacccacc gcgugcccua ucauaucucu     1860

uucggcagcc ggauuccugg gacaagagga cgccagagag cgacgccgga cgcucccccu     1920

gccgaucugc aggacuuucu cucccggauc uuccaggugc ccccuggcca aaugcccaau     1980

gggaacuuuu ucgccgcucc ucagcccgcc ccgggagcgg ccgcugccag caaaccuaau     2040

ucuaccgucc ccaagggcga ggcuaagccu aaacgcagaa agaaaguccg gcgccccuuu     2100

cagagauga                                                             2109


<210>  8227
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC15__Homo_sapiens__Q9Y5T4

<400>  8227

Met Ala Ala Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Arg Tyr 
1               5                   10                  15      


Ala Glu Tyr Leu Gln Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp 
            20                  25                  30          


Gln Gln Arg Leu Val Arg Ser Leu Ile Ala Val Gly Leu Gly Val Ala 
        35                  40                  45              


Ala Leu Ala Phe Ala Gly Arg Tyr Ala Phe Arg Ile Trp Lys Pro Leu 
    50                  55                  60                  


Glu Gln Val Ile Thr Glu Thr Ala Lys Lys Ile Ser Thr Pro Ser Phe 
65                  70                  75                  80  


Ser Ser Tyr Tyr Lys Gly Gly Phe Glu Gln Lys Met Ser Arg Arg Glu 
                85                  90                  95      


Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile 
            100                 105                 110         


Arg Thr Ala His Arg Arg Val Met Ile Leu Asn His Pro Asp Lys Gly 
        115                 120                 125             


Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu 
    130                 135                 140                 


Glu Thr Thr Thr Lys His 
145                 150 


<210>  8228
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC15__Homo_sapiens__AAH95400

<400>  8228
auggcugccc guggugucau cgcuccaguu ggcgagaguu ugcgcuacgc ugaguacuug       60

cagcccucgg ccaaacggcc agacgccgac gucgaccagc agagacuggu aagaaguuug      120

auagcuguag gccugggugu ugcagcucuu gcauuugcag gucgcuacgc auuucggauc      180

uggaaaccuc uagaacaagu uaucacagaa acugcaaaga agauuucaac uccuagcuuu      240

ucauccuacu auaaaggagg auuugaacag aaaaugagua ggcgagaagc uggucuuauu      300

uuagguguaa gcccaucugc uggcaaggcu aagauuagaa cagcucauag gagagucaug      360

auuuugaauc acccagauaa agguggaucu ccuuacguag cagccaaaau aaaugaagca      420

aaagacuugc uagaaacaac caccaaacau uga                                   453


<210>  8229
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC15__Homo_sapiens__AAH95400

<400>  8229
auggccgccc gcggcgugau cgcgcccguc ggggagagcc ugcgguacgc cgaguaccuc       60

cagccguccg ccaagcgccc cgacgccgac guggaccagc agcggcuggu gcgcagccug      120

aucgccgucg gccucggggu ggcggcccug gccuucgccg gccgguacgc guuccgcauc      180

uggaagcccc uggagcaggu caucaccgag accgccaaga agaucuccac gcccagcuuc      240

uccagcuacu acaagggcgg guucgagcag aagauguccc ggcgcgaggc cggccucauc      300

cuggggguga gcccguccgc cggcaaggcc aagauccgga ccgcgcaccg ccgggugaug      360

auccugaacc accccgacaa gggcgggagc cccuacgugg ccgccaagau caacgaggcc      420

aaggaccucc uggagaccac cacgaagcac uga                                   453


<210>  8230
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC15__Homo_sapiens__AAH95400

<400>  8230
auggccgccc gcggcgucau cgcccccguc ggcgaguccc uccgcuacgc cgaguaccuc       60

cagcccuccg ccaagcgccc cgacgccgac gucgaccagc agcgccucgu ccgcucccuc      120

aucgccgucg gccucggcgu cgccgcccuc gccuucgccg gccgcuacgc cuuccgcauc      180

uggaagcccc ucgagcaggu caucaccgag accgccaaga agaucuccac ccccuccuuc      240

uccuccuacu acaagggcgg cuucgagcag aagauguccc gccgcgaggc cggccucauc      300

cucggcgucu cccccuccgc cggcaaggcc aagauccgca ccgcccaccg ccgcgucaug      360

auccucaacc accccgacaa gggcggcucc cccuacgucg ccgccaagau caacgaggcc      420

aaggaccucc ucgagaccac caccaagcac uga                                   453


<210>  8231
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC15__Homo_sapiens__AAH95400

<400>  8231
auggccgcua gaggcgugau cgcacccguc ggggagagcc ugagguacgc cgaauaucuc       60

cagccuuccg cgaagcggcc agacgcugau guugaccaac agcgccuugu gcgaucucug      120

auugccguag gauugggugu ggcagccuua gcuuucgcag gccguuacgc cuuuagaaua      180

uggaaaccgc uggagcaggu caucaccgaa acagcuaaga aaauuucaac ucccaguuuc      240

agcuccuauu acaaaggggg auuugagcag aagaugucua ggcgggaagc cggccuaauc      300

cucggugugu cgccuucagc ggggaaggca aagauucgca cggcccacag aaggguuaug      360

auccugaacc auccagauaa aggaggcagc cccuaugugg cugccaagau aaaugaggca      420

aaagaccuuc uggagaccac aacuaagcac uga                                   453


<210>  8232
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC15__Homo_sapiens__AAH95400

<400>  8232
auggccgcca gaggcgugau cgcccccgug ggcgagagcc ugagauacgc cgaguaccug       60

cagcccagcg ccaagagacc cgacgccgac guggaccagc agagacuggu gagaagccug      120

aucgccgugg gccugggcgu ggccgcccug gccuucgccg gcagauacgc cuucagaauc      180

uggaagcccc uggagcaggu gaucaccgag accgccaaga agaucagcac ccccagcuuc      240

agcagcuacu acaagggcgg cuucgagcag aagaugagca gaagagaggc cggccugauc      300

cugggcguga gccccagcgc cggcaaggcc aagaucagaa ccgcccacag aagagugaug      360

auccugaacc accccgacaa gggcggcagc cccuacgugg ccgccaagau caacgaggcc      420

aaggaccugc uggagaccac caccaagcac uga                                   453


<210>  8233
<211>  453
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC15__Homo_sapiens__AAH95400

<400>  8233
auggccgcua gaggcgugau cgcccccguc ggggagagcc ugcgguacgc ggaauaucuc       60

cagccuuccg cuaagcgccc ggacgccgau guugaccaac agagacuggu gcggucucuu      120

auugccgugg gacugggcgu cgcugcccuc gcuuucgccg ggcgcuacgc guuuagaauc      180

uggaaacccc uggaacaggu gauuaccgag acagccaaga aaaucagcac gccuuccuuc      240

ucuagcuauu acaagggagg cuuugagcag aaaauguccc ggcgcgaagc ugggcuuauu      300

cugggaguuu cucccagcgc cggcaaggcu aagaucagaa ccgcccaccg gcgcgugaug      360

auccucaacc auccugauaa aggcgggucc cccuaugucg cggccaagau uaaugaggcu      420

aaagaccugc uggagacaac cacaaagcac uga                                   453


<210>  8234
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC16__Homo_sapiens__Q9Y2G8

<400>  8234

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu His Phe 
                645                 650                 655     


Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr Leu Leu 
            660                 665                 670         


Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp Lys His 
        675                 680                 685             


Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His 
    690                 695                 700                 


Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly 
                725                 730                 735     


Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys 
            740                 745                 750         


Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly 
        755                 760                 765             


Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
    770                 775                 780         


<210>  8235
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC16__Homo_sapiens__AAH47363

<400>  8235
auggaaguga gaaaguugag cauuuccugg caguucuuga uaguucuggu ucugauccug       60

caaauucugu cugcguugga uuuugaccca uacagagucc uaggggucag ccgaacagcc      120

agucaggcug auauuaaaaa ggcuuauaag aagcucgccc gggaauggca uccugacaaa      180

aacaaagauc cuggagcaga agacaaguuc auucaaauca guaaggcuua cgagauucuu      240

ucaaaugaag aaaagagauc aaauuaugau caauauggag acgcuggaga gaaccagggc      300

uaccagaagc agcaacagca gcgagaguau cgcuuccgcc auuuccauga aaauuuuuau      360

uuugaugaau ccuuuuuuca cuucccuuuu aauucugaac ggcgggacuc aauugacgaa      420

aaguauuuau ugcacuuuuc acauuaugug aaugaagugg uuccagauag cuucaagaaa      480

cccuaccuca ucaagaucac cuccgauugg ugcuuuagcu gcauucauau cgagccugug      540

uggaaagaag ucauucaaga acuggaagaa uuggguguag gaauuggcgu gguccaugcu      600

ggguaugaga gacgccuggc ccaucaccua ggggcacaca gcacgcccuc uauccuagga      660

aucauuaacg ggaaaaucuc cuucuuccac aaugcaguug uccgugaaaa ucugcgacaa      720

uuuguagaaa gucuucuucc agggaacuug guggagaaag uuacaaauaa aaauuacguc      780

agauuccucu cuggcuggca gcaagagaau aagccucaug uccuucuguu ugaccaaacg      840

cccauugugc cacuguuaua caaguugacu gccuuugcau acaaagauua uuuaucauuu      900

ggauauguau auguggguuu gagagggacg gaagagauga caaggcggua caacaucaau      960

aucuacgccc cuacccucuu ggucuuuaaa gaacauauaa acaggccugc cgauguuauc     1020

caggcccgag guaugaagaa gcaaaucauu gacgacuuca ucacccgaaa caaauaucua     1080

uuggcagcca ggcucaccag ccagaaguug uuccaugaac ucugcccugu gaaacggucg     1140

caucgacaga ggaaguacug ugugguuuua uugacugcug agacuaccaa guugagcaaa     1200

cccuuugagg cuuuccuguc cuuugcccug gcaaacacuc aagacacagu gagauuugug     1260

caugucuaca gcaaucggca gcaggaguuu gccgacaccu uacuaccaga cagugaggcg     1320

uuucaaggga aaucagcggu gucuauuuua gaaaggcgca acacagcagg aaggguggug     1380

uauaaaaccc uggaagaccc uuggauuggg agugagagug acaaauuuau ccucuugggc     1440

uaucucgacc agcugcguaa agauccagcu cuucuguccu cugaagcagu gcuuccugac     1500

cugaccgaug aacuugcccc uguuuuucuc cuucgauggu ucuacucugc uucugacuac     1560

aucucagacu gcugggauag cauuuuucac aacaacugga gggaaaugau gccccugcug     1620

ucccugaucu ucucugcccu cuucauccuc uucggcacug ucaucguuca ggcuuucagc     1680

gacucuaaug augagcgaga gucaagcccu ccagaaaaag aggaagccca agagaagacu     1740

gggaaaacug agccaagcuu caccaaagaa aacagcagca agauuccuaa aaaaggcuuu     1800

guggagguaa cugaacucac agauguaaca uacaccagua acuugguacg ucugaggcca     1860

ggccacauga augugguccu cauccugucg aauucuacca agaccagccu acuacagaaa     1920

uuugcuuugg aggucuacac auuuacuggg agcagcugcc uacacuucuc cuuccugagu     1980

cuagauaaac acagagaaug gcuagaauac uuacuagaau uugcucaaga ugcagcucca     2040

aucccaaacc aauaugauaa gcauuucaug gagcgugacu acacugguua uguacuggcu     2100

cugaauggcc acaagaaaua cuucugccuc uucaagcccc aaaagacagu cgaagaggag     2160

gaagccauag ggucgugcag ugauguugac ucuucccucu accuggguga aucucgaggg     2220

aaaccuuccu guggccuugg auccaggccc aucaaaggaa aguugagcaa gcucucuuua     2280

uggauggaac gccugcugga gggcuccuua cagagguuuu auaucccauc auggccugaa     2340

cuagacuga                                                             2349


<210>  8236
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC16__Homo_sapiens__AAH47363

<400>  8236
auggaggugc gcaagcugag caucuccugg caguuccuca ucguccuggu gcugauccuc       60

cagauccuga gcgcccugga cuucgacccc uaccgggugc ucggcgucuc ccgcaccgcc      120

agccaggcgg acaucaagaa ggccuacaag aagcuggccc gggaguggca cccggacaag      180

aacaaggacc ccggggccga ggacaaguuc auccagaucu ccaaggccua cgagauccug      240

agcaacgagg agaagcgcuc caacuacgac caguacggcg acgcggggga gaaccagggc      300

uaccagaagc agcagcagca gcgggaguac cgcuuccggc acuuccacga gaacuucuac      360

uucgacgaga gcuucuucca cuuccccuuc aacuccgagc gccgggacag caucgacgag      420

aaguaccucc ugcacuucuc ccacuacgug aacgaggugg uccccgacag cuucaagaag      480

ccguaccuga ucaagaucac cuccgacugg ugcuucagcu gcauccacau cgagcccgug      540

uggaaggagg ugauccagga gcucgaggag cugggggucg gcaucggcgu ggugcacgcc      600

ggguacgagc gccggcuggc ccaccaccuc ggcgcccacu ccacgcccag cauccugggg      660

aucaucaacg gcaagaucuc cuucuuccac aacgcggucg ugcgcgagaa ccugcggcag      720

uucguggaga gccuccugcc cgggaaccug gucgagaagg ugaccaacaa gaacuacgug      780

cgcuuccucu ccggcuggca gcaggagaac aagccgcacg uccugcuguu cgaccagacc      840

cccaucgugc cccuccugua caagcugacc gccuucgccu acaaggacua ccucagcuuc      900

ggcuacgugu acgucgggcu gcggggcacg gaggagauga cccgccggua caacaucaac      960

aucuacgccc ccacccugcu cguguucaag gagcacauca accgcccggc cgacgugauc     1020

caggcgcggg ggaugaagaa gcagaucauc gacgacuuca ucacccgcaa caaguaccug     1080

cuggccgccc ggcucacgag ccagaagcug uuccacgagc ugugccccgu caagcgcucc     1140

caccgccagc ggaaguacug cgugguccuc cugaccgccg agaccaccaa gcugagcaag     1200

cccuucgagg ccuuccucuc cuucgcgcug gccaacacgc aggacaccgu gcgcuucgug     1260

cacgucuaca gcaaccggca gcaggaguuc gccgacaccc ugcuccccga cuccgaggcc     1320

uuccagggca agagcgccgu guccauccug gagcgccgga acaccgcggg ccgcgugguc     1380

uacaagacgc uggaggaccc guggaucggg agcgaguccg acaaguucau ccuccugggc     1440

uaccuggacc agcuccggaa ggaccccgcc cugcugagcu ccgaggccgu gcugcccgac     1500

cucaccgacg agcuggcccc cguguuccug cuccgcuggu ucuacagcgc cuccgacuac     1560

aucagcgacu gcugggacuc caucuuccac aacaacuggc gggagaugau gccgcugcug     1620

agccucaucu ucuccgcgcu guucauccug uucgggaccg ucaucgugca ggccuucagc     1680

gacuccaacg acgagcgcga gagcagcccg cccgagaagg aggaggccca ggagaagacc     1740

ggcaagacgg agcccuccuu caccaaggag aacagcucca agauccccaa gaagggguuc     1800

guggagguca ccgagcucac cgacgugacg uacaccagca accuggugcg gcugcgcccc     1860

ggccacauga acgucgugcu cauccugucc aacagcacca agaccucccu gcuccagaag     1920

uucgcccugg agguguacac guucaccggc agcuccugcc ugcacuucag cuuccucucc     1980

cuggacaagc accgggagug gcuggaguac cuccuggagu ucgcgcagga cgccgccccc     2040

auccccaacc aguacgacaa gcacuucaug gagcgcgacu acaccgggua cguccuggcc     2100

cucaacggcc acaagaagua cuucugccug uucaagccgc agaagaccgu ggaggaggag     2160

gaggccaucg ggagcugcuc cgacguggac agcucccugu accucggcga gagccggggg     2220

aagcccuccu gcggccuggg cagccgcccc aucaagggga agcugagcaa gcucucccug     2280

uggauggagc ggcugcucga gggcagccug cagcgcuucu acaucccguc cuggcccgag     2340

cuggacuga                                                             2349


<210>  8237
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC16__Homo_sapiens__AAH47363

<400>  8237
auggaggucc gcaagcucuc caucuccugg caguuccuca ucguccucgu ccucauccuc       60

cagauccucu ccgcccucga cuucgacccc uaccgcgucc ucggcgucuc ccgcaccgcc      120

ucccaggccg acaucaagaa ggccuacaag aagcucgccc gcgaguggca ccccgacaag      180

aacaaggacc ccggcgccga ggacaaguuc auccagaucu ccaaggccua cgagauccuc      240

uccaacgagg agaagcgcuc caacuacgac caguacggcg acgccggcga gaaccagggc      300

uaccagaagc agcagcagca gcgcgaguac cgcuuccgcc acuuccacga gaacuucuac      360

uucgacgagu ccuucuucca cuuccccuuc aacuccgagc gccgcgacuc caucgacgag      420

aaguaccucc uccacuucuc ccacuacguc aacgaggucg uccccgacuc cuucaagaag      480

cccuaccuca ucaagaucac cuccgacugg ugcuucuccu gcauccacau cgagcccguc      540

uggaaggagg ucauccagga gcucgaggag cucggcgucg gcaucggcgu cguccacgcc      600

ggcuacgagc gccgccucgc ccaccaccuc ggcgcccacu ccacccccuc cauccucggc      660

aucaucaacg gcaagaucuc cuucuuccac aacgccgucg uccgcgagaa ccuccgccag      720

uucgucgagu cccuccuccc cggcaaccuc gucgagaagg ucaccaacaa gaacuacguc      780

cgcuuccucu ccggcuggca gcaggagaac aagccccacg uccuccucuu cgaccagacc      840

cccaucgucc cccuccucua caagcucacc gccuucgccu acaaggacua ccucuccuuc      900

ggcuacgucu acgucggccu ccgcggcacc gaggagauga cccgccgcua caacaucaac      960

aucuacgccc ccacccuccu cgucuucaag gagcacauca accgccccgc cgacgucauc     1020

caggcccgcg gcaugaagaa gcagaucauc gacgacuuca ucacccgcaa caaguaccuc     1080

cucgccgccc gccucaccuc ccagaagcuc uuccacgagc ucugccccgu caagcgcucc     1140

caccgccagc gcaaguacug cgucguccuc cucaccgccg agaccaccaa gcucuccaag     1200

cccuucgagg ccuuccucuc cuucgcccuc gccaacaccc aggacaccgu ccgcuucguc     1260

cacgucuacu ccaaccgcca gcaggaguuc gccgacaccc uccuccccga cuccgaggcc     1320

uuccagggca aguccgccgu cuccauccuc gagcgccgca acaccgccgg ccgcgucguc     1380

uacaagaccc ucgaggaccc cuggaucggc uccgaguccg acaaguucau ccuccucggc     1440

uaccucgacc agcuccgcaa ggaccccgcc cuccucuccu ccgaggccgu ccuccccgac     1500

cucaccgacg agcucgcccc cgucuuccuc cuccgcuggu ucuacuccgc cuccgacuac     1560

aucuccgacu gcugggacuc caucuuccac aacaacuggc gcgagaugau gccccuccuc     1620

ucccucaucu ucuccgcccu cuucauccuc uucggcaccg ucaucgucca ggccuucucc     1680

gacuccaacg acgagcgcga guccuccccc cccgagaagg aggaggccca ggagaagacc     1740

ggcaagaccg agcccuccuu caccaaggag aacuccucca agauccccaa gaagggcuuc     1800

gucgagguca ccgagcucac cgacgucacc uacaccucca accucguccg ccuccgcccc     1860

ggccacauga acgucguccu cauccucucc aacuccacca agaccucccu ccuccagaag     1920

uucgcccucg aggucuacac cuucaccggc uccuccugcc uccacuucuc cuuccucucc     1980

cucgacaagc accgcgagug gcucgaguac cuccucgagu ucgcccagga cgccgccccc     2040

auccccaacc aguacgacaa gcacuucaug gagcgcgacu acaccggcua cguccucgcc     2100

cucaacggcc acaagaagua cuucugccuc uucaagcccc agaagaccgu cgaggaggag     2160

gaggccaucg gcuccugcuc cgacgucgac uccucccucu accucggcga gucccgcggc     2220

aagcccuccu gcggccucgg cucccgcccc aucaagggca agcucuccaa gcucucccuc     2280

uggauggagc gccuccucga gggcucccuc cagcgcuucu acauccccuc cuggcccgag     2340

cucgacuga                                                             2349


<210>  8238
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC16__Homo_sapiens__AAH47363

<400>  8238
auggagguga gaaagcugag caucuccugg caguuccuca uuguccuugu ucugauauug       60

caaaucuuau cugcccugga cuuugauccc uacagggugc uaggcguauc acggaccgcu      120

agucaggcag acauuaaaaa ggccuauaaa aagcucgcgc gcgaauggca cccugauaaa      180

aacaaggacc caggggcuga ggauaaguuc auccagauua gcaaagccua cgaaauccug      240

uccaaugagg aaaagcgauc uaacuaugac caguacggag augccgguga gaaucaaggc      300

uaucagaaac agcagcaaca gcgugaguac agauuuaggc auuuccacga aaacuuuuau      360

uucgacgagu cguuuuucca uuuuccguuc aauucagaac ggcgcgauag cauagacgag      420

aaguaccuuc ugcacuuuag ucauuacgug aacgaggucg ugcccgauuc cuucaaaaag      480

ccuuauuuga ucaagauuac aucugacugg ugcuuuagcu guauccacau ugaaccaguu      540

uggaaagagg ugauccagga acucgaggaa cugggggucg gaauaggcgu gguacacgca      600

gguuacgaga gaaggcuggc ucaucaccuc ggggcacauu ccacucccuc aauuuuagga      660

aucauuaaug gcaagaucag uuucuuccac aacgccguug ugcgggagaa ucugcgccag      720

uuugucgaaa gccuuuugcc uggcaaccug guggagaaag ugacgaauaa gaacuauguc      780

cgauuccuau cuggguggca acaggaaaau aaaccacacg uucuccuguu ugaucagacc      840

cccaucgugc cucuucugua caaguugaca gcuuucgccu auaaagacua ccucuccuuu      900

ggauauguau acgugggucu gagaggcacu gaggaaauga ccaggcggua caacauuaau      960

auauaugcgc caacauuacu ggucuucaag gagcauauca accguccggc agacgugauu     1020

caagcccgcg ggaugaagaa acagaucaua gaugacuuua uuaccagaaa caaguaccuc     1080

cuugcugcca ggcugacuuc acagaaauug uuccacgagc uaugccccgu uaagcggagc     1140

caucgacagc gcaaauauug ugugguccug cucacagcag aaaccacgaa gcugaguaag     1200

ccuuuugagg cuuuccuuuc uuuugcccug gcgaauacuc aagauaccgu gagauucgua     1260

cacguuuacu ccaacaggca gcaggaauuu gccgacacau ugcucccaga uagcgaggca     1320

uuccagggaa aaucggcugu gucuauccug gaacggcgca auacugccgg cagagucgug     1380

uauaagaccu uagaggaccc cuggaucggu uccgagucag auaaauucau ucugcuaggg     1440

uaccucgacc aacugaggaa ggauccugcu cuuuugagua gcgaagccgu ccugccagac     1500

cucacagaug agcuggcacc cguguuucuu cugcguuggu ucuauuccgc cucugacuac     1560

aucagcgacu gcugggauuc aauuuuucau aacaauuggc gggaaaugau gccguugcuc     1620

agucugauau ucuccgcuuu auuuauccug uucggaaccg uuauugugca ggcguuuagc     1680

gacucuaacg augagcgaga gucaaguccu cccgaaaaag aggaagcaca ggagaagacg     1740

ggcaagacug aaccauccuu cacaaaagaa aauagcucua agaucccuaa aaagggcuuu     1800

guagagguca ccgaacuaac ugacgugaca uacaccucga accucguuag acugaggccc     1860

gggcacauga augugguccu uaucuugagc aacuccacga aaaccucacu gcuccagaag     1920

uucgcccugg agguguauac auuuacugga aguucuuguu uacacuucag cuuucugucc     1980

cuugauaagc aucgcgaaug guuggaguac cuccuggagu ucgcucaaga cgccgcacca     2040

auucccaauc aguaugauaa acacuucaug gagcgggacu acaccgguua uguacuagcc     2100

cugaacggcc auaagaaaua cuuuugccuc uucaagccuc agaaaacagu ggaggaagag     2160

gaagcuauag ggucauguag cgauguugac ucuucccugu aucuuggaga gaguagaggc     2220

aagccaagcu gcgguuuggg gucuaggccg aucaaaggca agcuguccaa guuaucacuc     2280

uggauggaac gccugcuuga gggaagucug cagcgauuuu acauucccag cuggccugag     2340

uuggauuga                                                             2349


<210>  8239
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC16__Homo_sapiens__AAH47363

<400>  8239
auggagguga gaaagcugag caucagcugg caguuccuga ucgugcuggu gcugauccug       60

cagauccuga gcgcccugga cuucgacccc uacagagugc ugggcgugag cagaaccgcc      120

agccaggccg acaucaagaa ggccuacaag aagcuggcca gagaguggca ccccgacaag      180

aacaaggacc ccggcgccga ggacaaguuc auccagauca gcaaggccua cgagauccug      240

agcaacgagg agaagagaag caacuacgac caguacggcg acgccggcga gaaccagggc      300

uaccagaagc agcagcagca gagagaguac agauucagac acuuccacga gaacuucuac      360

uucgacgaga gcuucuucca cuuccccuuc aacagcgaga gaagagacag caucgacgag      420

aaguaccugc ugcacuucag ccacuacgug aacgaggugg ugcccgacag cuucaagaag      480

cccuaccuga ucaagaucac cagcgacugg ugcuucagcu gcauccacau cgagcccgug      540

uggaaggagg ugauccagga gcuggaggag cugggcgugg gcaucggcgu ggugcacgcc      600

ggcuacgaga gaagacuggc ccaccaccug ggcgcccaca gcacccccag cauccugggc      660

aucaucaacg gcaagaucag cuucuuccac aacgccgugg ugagagagaa ccugagacag      720

uucguggaga gccugcugcc cggcaaccug guggagaagg ugaccaacaa gaacuacgug      780

agauuccuga gcggcuggca gcaggagaac aagccccacg ugcugcuguu cgaccagacc      840

cccaucgugc cccugcugua caagcugacc gccuucgccu acaaggacua ccugagcuuc      900

ggcuacgugu acgugggccu gagaggcacc gaggagauga ccagaagaua caacaucaac      960

aucuacgccc ccacccugcu gguguucaag gagcacauca acagacccgc cgacgugauc     1020

caggccagag gcaugaagaa gcagaucauc gacgacuuca ucaccagaaa caaguaccug     1080

cuggccgcca gacugaccag ccagaagcug uuccacgagc ugugccccgu gaagagaagc     1140

cacagacaga gaaaguacug cguggugcug cugaccgccg agaccaccaa gcugagcaag     1200

cccuucgagg ccuuccugag cuucgcccug gccaacaccc aggacaccgu gagauucgug     1260

cacguguaca gcaacagaca gcaggaguuc gccgacaccc ugcugcccga cagcgaggcc     1320

uuccagggca agagcgccgu gagcauccug gagagaagaa acaccgccgg cagaguggug     1380

uacaagaccc uggaggaccc cuggaucggc agcgagagcg acaaguucau ccugcugggc     1440

uaccuggacc agcugagaaa ggaccccgcc cugcugagca gcgaggccgu gcugcccgac     1500

cugaccgacg agcuggcccc cguguuccug cugagauggu ucuacagcgc cagcgacuac     1560

aucagcgacu gcugggacag caucuuccac aacaacugga gagagaugau gccccugcug     1620

agccugaucu ucagcgcccu guucauccug uucggcaccg ugaucgugca ggccuucagc     1680

gacagcaacg acgagagaga gagcagcccc cccgagaagg aggaggccca ggagaagacc     1740

ggcaagaccg agcccagcuu caccaaggag aacagcagca agauccccaa gaagggcuuc     1800

guggagguga ccgagcugac cgacgugacc uacaccagca accuggugag acugagaccc     1860

ggccacauga acguggugcu gauccugagc aacagcacca agaccagccu gcugcagaag     1920

uucgcccugg agguguacac cuucaccggc agcagcugcc ugcacuucag cuuccugagc     1980

cuggacaagc acagagagug gcuggaguac cugcuggagu ucgcccagga cgccgccccc     2040

auccccaacc aguacgacaa gcacuucaug gagagagacu acaccggcua cgugcuggcc     2100

cugaacggcc acaagaagua cuucugccug uucaagcccc agaagaccgu ggaggaggag     2160

gaggccaucg gcagcugcag cgacguggac agcagccugu accugggcga gagcagaggc     2220

aagcccagcu gcggccuggg cagcagaccc aucaagggca agcugagcaa gcugagccug     2280

uggauggaga gacugcugga gggcagccug cagagauucu acauccccag cuggcccgag     2340

cuggacuga                                                             2349


<210>  8240
<211>  2349
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC16__Homo_sapiens__AAH47363

<400>  8240
auggagguga gaaagcugag caucuccugg caguuccuca uuguccuggu ucuuauccug       60

caaauucucu cugcccugga cuuugauccc uaccgggugc uuggcgugag ccgcaccgcu      120

ucccaggccg acaucaaaaa ggcguauaaa aagcuggcua gagaauggca cccugauaaa      180

aacaaggacc cgggggccga ggauaaguuc auucagaucu cuaaagccua cgaaauccuc      240

agcaaugagg aaaagcgguc caacuaugac caguacggag augcuggcga gaaucaaggg      300

uaucagaaac agcagcaaca gcgcgaguac agauuucggc auuuccacga aaacuuuuau      360

uucgacgagu cuuucuucca uuuucccuuc aauagcgaac gcagagauuc cauugacgag      420

aaguaccugc ugcacuuuag ccauuacguc aacgaggugg uuccugauuc uuucaaaaag      480

cccuaucuca ucaagauuac auccgacugg ugcuuuagcu guauccacau ugaaccugug      540

uggaaagagg ucauccagga acuggaggaa cuuggagugg gcauuggggu ugugcacgcc      600

ggauacgagc ggcgccuggc ucaucaccuc ggcgcccauu cuacgcccuc cauccugggc      660

aucauuaaug ggaagaucag cuucuuccac aacgcggucg ugagagagaa ucuucggcag      720

uuuguggaau cucugcuccc uggaaaccug gucgagaaag uuaccaauaa gaacuaugug      780

cgcuuccugu ccggcuggca acaggaaaau aaaccgcacg ugcuccuguu ugaucagaca      840

cccauugucc cucuucugua caagcucacc gccuucgcuu auaaagacua ccugagcuuu      900

ggguaugugu acguuggacu uagaggcaca gaggaaauga cccggcgcua caacaucaau      960

auuuaugccc ccacacugcu cguguucaag gagcauauca acagaccugc ugacgucauc     1020

caagcccggg ggaugaagaa acagauuauc gaugacuuua uuaccagaaa caaguaccug     1080

cuggcggccc gccucacguc ccagaaacug uuccacgagc uuugccccgu gaagcggucu     1140

cauagacagc gcaaauauug uguugugcug cucaccgcug aaacaaccaa gcugagcaag     1200

ccguuugagg ccuuccuuuc cuuugcucug gccaauacac aagauaccgu ccgguucgug     1260

cacgucuaca gcaacagaca gcaggaauuu gccgacacgc uccugccuga uucugaggcu     1320

uuccagggaa aauccgcggu gagcauccug gaacgccgga auacagccgg cagaguugug     1380

uauaagaccc ucgaggaccc cuggauuggc ucugagagcg auaaauucau ccugcuuggg     1440

uaccuggacc aacuccgcaa ggauccugcu cugcuguccu cugaagccgu ccuucccgac     1500

cucacagaug agcuggcccc cguguuucug cuccgguggu ucuauagcgc uuccgacuac     1560

aucagcgacu gcugggauuc uauuuuucau aacaauugga gagaaaugau gccucugcuu     1620

ucccugaucu ucagcgcccu cuuuauucug uucggaaccg uuaucgugca ggcguuuucu     1680

gacuccaacg augagcgcga gagcuccccg cccgaaaaag aggaagcuca ggagaagacc     1740

ggcaagacag aaccuucuuu cacgaaagag aauagcucca agauucccaa aaagggguuu     1800

gucgagguga ccgaacugac agacgugacc uacacaucua accuuguucg gcucagaccu     1860

ggacacauga augucgugcu gauccugagc aacuccacca aaacgagccu ccugcagaag     1920

uucgcccuug agguguauac auuuaccggg ucuuccuguc ugcacuucag cuuucucucu     1980

cuggauaagc aucgggaaug gcuggaguac cuucucgaau uugcccaaga cgcugccccc     2040

auuccgaauc aguaugauaa acacuucaug gagcgcgacu acaccggcua uguccuggcu     2100

cugaacggac auaagaaaua cuuuugccuc uucaagccuc agaaaacagu ggaggaagag     2160

gaagccaucg gcuccuguag cgauguugac ucuagccugu aucuuggcga guccagaggg     2220

aagcccagcu gcggacuggg cucucggccu aucaaaggga agcucuccaa gcugagccug     2280

uggauggaaa gacuucucga gggaucccug cagcgcuuuu acauucccuc uuggccugag     2340

cuggauuga                                                             2349


<210>  8241
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC17__Homo_sapiens__Q9NVM6

<400>  8241

Met Ala Val Thr Lys Glu Leu Leu Gln Met Asp Leu Tyr Ala Leu Leu 
1               5                   10                  15      


Gly Ile Glu Glu Lys Ala Ala Asp Lys Glu Val Lys Lys Ala Tyr Arg 
            20                  25                  30          


Gln Lys Ala Leu Ser Cys His Pro Asp Lys Asn Pro Asp Asn Pro Arg 
        35                  40                  45              


Ala Ala Glu Leu Phe His Gln Leu Ser Gln Ala Leu Glu Val Leu Thr 
    50                  55                  60                  


Asp Ala Ala Ala Arg Ala Ala Tyr Asp Lys Val Arg Lys Ala Lys Lys 
65                  70                  75                  80  


Gln Ala Ala Glu Arg Thr Gln Lys Leu Asp Glu Lys Arg Lys Lys Val 
                85                  90                  95      


Lys Leu Asp Leu Glu Ala Arg Glu Arg Gln Ala Gln Ala Gln Glu Ser 
            100                 105                 110         


Glu Glu Glu Glu Glu Ser Arg Ser Thr Arg Thr Leu Glu Gln Glu Ile 
        115                 120                 125             


Glu Arg Leu Arg Glu Glu Gly Ser Arg Gln Leu Glu Glu Gln Gln Arg 
    130                 135                 140                 


Leu Ile Arg Glu Gln Ile Arg Gln Glu Arg Asp Gln Arg Leu Arg Gly 
145                 150                 155                 160 


Lys Ala Glu Asn Thr Glu Gly Gln Gly Thr Pro Lys Leu Lys Leu Lys 
                165                 170                 175     


Trp Lys Cys Lys Lys Glu Asp Glu Ser Lys Gly Gly Tyr Ser Lys Asp 
            180                 185                 190         


Val Leu Leu Arg Leu Leu Gln Lys Tyr Gly Glu Val Leu Asn Leu Val 
        195                 200                 205             


Leu Ser Ser Lys Lys Pro Gly Thr Ala Val Val Glu Phe Ala Thr Val 
    210                 215                 220                 


Lys Ala Ala Glu Leu Ala Val Gln Asn Glu Val Gly Leu Val Asp Asn 
225                 230                 235                 240 


Pro Leu Lys Ile Ser Trp Leu Glu Gly Gln Pro Gln Asp Ala Val Gly 
                245                 250                 255     


Arg Ser His Ser Gly Leu Ser Lys Gly Ser Val Leu Ser Glu Arg Asp 
            260                 265                 270         


Tyr Glu Ser Leu Val Met Met Arg Met Arg Gln Ala Ala Glu Arg Gln 
        275                 280                 285             


Gln Leu Ile Ala Arg Met Gln Gln Glu Asp Gln Glu Gly Pro Pro Thr 
    290                 295                 300                 






<210>  8242
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC17__Homo_sapiens__AAH00048

<400>  8242
auggcaguga ccaaggagcu cuuacagaug gaccuguacg cgcugcuagg cauugaggag       60

aaggcagcgg acaaagaggu aaagaaggcg uauaggcaga aggcccucuc cugccaccca      120

gacaaaaauc cagauaaucc cagagcagcu gaacucuucc accagcuuuc ucaggccuug      180

gaggugcuga ccgaugcugc agccagggcu gcauaugaca aggucaggaa agccaagaag      240

caagcagcag agaggaccca gaaacuugau gagaaaagga agaaagugaa gcuugaccug      300

gaggcccggg agcggcaggc ccaggcccag gagagugagg aggaagagga gagccggagc      360

accaggacac uagagcaaga gaucgaacgc cugagagaag aggguucccg gcagcuggag      420

gaacagcaga ggcucauccg ggagcagaua cgccaggagc gugaccagag guugagagga      480

aaggcagaaa auacugaagg ccaaggaacc cccaaacuaa agcuaaaaug gaagugcaag      540

aaggaggaug agucaaaagg uggcuacucc aaagacgucc uccuacggcu uuugcagaag      600

uauggugagg uucucaaccu ggugcuuucc aguaagaagc caggcacugc ugugguggag      660

uuugcaaccg ucaaggcagc ggagcuggcu guccagaaug aaguuggccu gguggauaac      720

ccucugaaga uuuccugguu ggagggacag ccccaggaug ccgugggccg cagccacuca      780

ggacugucaa agggcucagu gcugucagag agggacuacg agagccucgu caugaugcgc      840

augcgccagg cggccgagcg gcaacagcug aucgcacgga ugcagcagga agaccaggag      900

gggccgccua cguag                                                       915


<210>  8243
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC17__Homo_sapiens__AAH00048

<400>  8243
auggccguga ccaaggagcu gcuccagaug gaccuguacg cccugcucgg caucgaggag       60

aaggcggccg acaaggaggu caagaaggcc uaccgccaga aggcccugag cugccacccc      120

gacaagaacc ccgacaaccc ccgggccgcg gagcuguucc accagcucuc ccaggcccug      180

gaggugcuga ccgacgccgc cgcgcgcgcc gccuacgaca aggugcggaa ggccaagaag      240

caggccgcgg agcgcacgca gaagcucgac gagaagcgga agaaggucaa gcuggaccug      300

gaggcccgcg agcggcaggc ccaggcccag gagagcgagg aggaggagga gucccgcagc      360

acccggaccc ucgagcagga gaucgagcgc cugcgggagg aggggucccg ccagcuggag      420

gagcagcagc ggcucauccg cgagcagauc cggcaggagc gcgaccagcg gcugcgcggc      480

aaggccgaga acaccgaggg gcagggcacg cccaagcuga agcucaagug gaagugcaag      540

aaggaggacg agagcaaggg cggguacucc aaggacgugc ugcugcggcu ccugcagaag      600

uacggcgagg ugcugaaccu cguccugagc uccaagaagc ccgggaccgc ggugguggag      660

uucgccaccg ucaaggccgc cgagcuggcc gugcagaacg aggugggccu cgucgacaac      720

ccgcugaaga ucagcuggcu ggaggggcag ccccaggacg cggugggccg cucccacagc      780

gggcucucca agggcagcgu gcuguccgag cgggacuacg agagccuggu caugaugcgc      840

augcgccagg ccgccgagcg gcagcagcuc aucgcccgca ugcagcagga ggaccaggag      900

ggcccgccca ccuga                                                       915


<210>  8244
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC17__Homo_sapiens__AAH00048

<400>  8244
auggccguca ccaaggagcu ccuccagaug gaccucuacg cccuccucgg caucgaggag       60

aaggccgccg acaaggaggu caagaaggcc uaccgccaga aggcccucuc cugccacccc      120

gacaagaacc ccgacaaccc ccgcgccgcc gagcucuucc accagcucuc ccaggcccuc      180

gagguccuca ccgacgccgc cgcccgcgcc gccuacgaca agguccgcaa ggccaagaag      240

caggccgccg agcgcaccca gaagcucgac gagaagcgca agaaggucaa gcucgaccuc      300

gaggcccgcg agcgccaggc ccaggcccag gaguccgagg aggaggagga gucccgcucc      360

acccgcaccc ucgagcagga gaucgagcgc cuccgcgagg agggcucccg ccagcucgag      420

gagcagcagc gccucauccg cgagcagauc cgccaggagc gcgaccagcg ccuccgcggc      480

aaggccgaga acaccgaggg ccagggcacc cccaagcuca agcucaagug gaagugcaag      540

aaggaggacg aguccaaggg cggcuacucc aaggacgucc uccuccgccu ccuccagaag      600

uacggcgagg uccucaaccu cguccucucc uccaagaagc ccggcaccgc cgucgucgag      660

uucgccaccg ucaaggccgc cgagcucgcc guccagaacg aggucggccu cgucgacaac      720

ccccucaaga ucuccuggcu cgagggccag ccccaggacg ccgucggccg cucccacucc      780

ggccucucca agggcuccgu ccucuccgag cgcgacuacg agucccucgu caugaugcgc      840

augcgccagg ccgccgagcg ccagcagcuc aucgcccgca ugcagcagga ggaccaggag      900

ggccccccca ccuga                                                       915


<210>  8245
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC17__Homo_sapiens__AAH00048

<400>  8245
auggccguga ccaaggagcu gcuccagaug gaccuuuacg cucuguuggg caucgaagag       60

aaagcagccg auaaggaagu caaaaaggcg uauagacaaa aggcuuuaag cugccacccc      120

gacaagaacc cugauaaucc aagggccgca gagcuguucc aucagcuauc ccaggcccuc      180

gaaguucuga cagacgcugc agcccgggcu gccuacgaua aggugcgcaa agcgaagaaa      240

caggcagccg agcgaacuca aaaacuugac gagaaacgua agaagguaaa acuggauuug      300

gaagcuagag agaggcaggc ccaggcacag gaaucugagg aggaagagga aucacggagu      360

acgcgcaccc ucgagcaaga aauugagaga cugagggagg aagggagccg gcagcuggag      420

gaacagcagc gccucauacg agagcaaauc agacaggaaa gggaccagcg guuacgugga      480

aaggcugaga acacagaggg ucaaggcacu ccgaaacuga aacuuaaaug gaaguguaaa      540

aaggaagaug aguccaaagg gggauauucu aaggacgugu ugcugcgccu acuccagaag      600

uacggcgaag uccugaaucu ugugcugucg ucaaagaagc ccgguaccgc cguuguggag      660

uuugcgacag ucaaagccgc agaauuggcu gugcagaacg agguagggcu cguugauaau      720

ccucugaaga uuagcugguu agagggacag ccacaagacg ccgugggcag aagucacucc      780

ggccugucua aggggagcgu ccucuccgaa agggauuaug agucacuugu gaugaugcgg      840

augcgacagg cugccgaacg ccagcagcug aucgcaagaa ugcaacagga ggaccaggag      900

ggacccccua ccuga                                                       915


<210>  8246
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC17__Homo_sapiens__AAH00048

<400>  8246
auggccguga ccaaggagcu gcugcagaug gaccuguacg cccugcuggg caucgaggag       60

aaggccgccg acaaggaggu gaagaaggcc uacagacaga aggcccugag cugccacccc      120

gacaagaacc ccgacaaccc cagagccgcc gagcuguucc accagcugag ccaggcccug      180

gaggugcuga ccgacgccgc cgccagagcc gccuacgaca aggugagaaa ggccaagaag      240

caggccgccg agagaaccca gaagcuggac gagaagagaa agaaggugaa gcuggaccug      300

gaggccagag agagacaggc ccaggcccag gagagcgagg aggaggagga gagcagaagc      360

accagaaccc uggagcagga gaucgagaga cugagagagg agggcagcag acagcuggag      420

gagcagcaga gacugaucag agagcagauc agacaggaga gagaccagag acugagaggc      480

aaggccgaga acaccgaggg ccagggcacc cccaagcuga agcugaagug gaagugcaag      540

aaggaggacg agagcaaggg cggcuacagc aaggacgugc ugcugagacu gcugcagaag      600

uacggcgagg ugcugaaccu ggugcugagc agcaagaagc ccggcaccgc cgugguggag      660

uucgccaccg ugaaggccgc cgagcuggcc gugcagaacg aggugggccu gguggacaac      720

ccccugaaga ucagcuggcu ggagggccag ccccaggacg ccgugggcag aagccacagc      780

ggccugagca agggcagcgu gcugagcgag agagacuacg agagccuggu gaugaugaga      840

augagacagg ccgccgagag acagcagcug aucgccagaa ugcagcagga ggaccaggag      900

ggccccccca ccuga                                                       915


<210>  8247
<211>  915
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC17__Homo_sapiens__AAH00048

<400>  8247
auggccguga ccaaggagcu gcuccagaug gaccuguacg cccuucuggg caucgaagag       60

aaagcugcgg auaaggaagu caaaaaggcu uauagacaaa aagcccucag cugccacccc      120

gacaagaacc cugauaaucc gcgggccgcu gagcuguucc aucagcuuuc ccaggcccug      180

gaaguucuca cagacgcugc cgcgcgcgcc gcuuacgaua aggugagaaa agccaagaaa      240

caggcugccg agcggacgca aaagcuggac gagaaacgca agaaggugaa acuggaucuc      300

gaagcgagag agcggcaggc ccaggcucag gaaucugagg aggaagagga aagccgcucc      360

accagaacac uggagcaaga aauugagcgg cuucgcgagg aagggucuag acagcuggag      420

gaacagcagc ggcucauccg cgagcaaauu agacaggaac gggaccagcg ccugagagga      480

aaggccgaga acaccgaggg ccaagggaca cccaaacuua agcugaaaug gaaguguaaa      540

aaggaagaug agagcaaggg aggcuauucc aaagacgucc uccugcggcu gcuccagaag      600

uacggggaag ugcugaaucu uguucugucu agcaaaaagc cuggaaccgc uguggucgag      660

uuugccacag ugaaagccgc ugaacucgcg guucagaacg aggugggccu ggucgauaau      720

ccccuuaaga ucuccuggcu ggagggccag ccucaagacg ccguggggag aagccacucu      780

ggacucucca agggcagcgu gcugucugaa cgcgauuaug agucccuggu caugaugcgg      840

augagacagg cugccgaacg ccagcagcuc auugcccgga ugcaacagga ggaccaggag      900

gggcccccua ccuga                                                       915


<210>  8248
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC18__Homo_sapiens__Q9H819

<400>  8248

Met Ala Ala Thr Leu Gly Ser Gly Glu Arg Trp Thr Glu Ala Tyr Ile 
1               5                   10                  15      


Asp Ala Val Arg Arg Asn Lys Tyr Pro Glu Asp Thr Pro Pro Glu Ser 
            20                  25                  30          


His Asp Pro Cys Gly Cys Cys Asn Cys Met Lys Ala Gln Lys Glu Lys 
        35                  40                  45              


Lys Ser Glu Asn Glu Trp Thr Gln Thr Arg Gln Gly Glu Gly Asn Ser 
    50                  55                  60                  


Thr Tyr Ser Glu Glu Gln Leu Leu Gly Val Gln Arg Ile Lys Lys Cys 
65                  70                  75                  80  


Arg Asn Tyr Tyr Glu Ile Leu Gly Val Ser Arg Asp Ala Ser Asp Glu 
                85                  90                  95      


Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Phe His Pro Asp 
            100                 105                 110         


Lys Asn Cys Ala Pro Gly Ala Thr Asp Ala Phe Lys Ala Ile Gly Asn 
        115                 120                 125             


Ala Phe Ala Val Leu Ser Asn Pro Asp Lys Arg Leu Arg Tyr Asp Glu 
    130                 135                 140                 


Tyr Gly Asp Glu Gln Val Thr Phe Thr Ala Pro Arg Ala Arg Pro Tyr 
145                 150                 155                 160 


Asn Tyr Tyr Arg Asp Phe Glu Ala Asp Ile Thr Pro Glu Glu Leu Phe 
                165                 170                 175     


Asn Val Phe Phe Gly Gly His Phe Pro Thr Gly Asn Ile His Met Phe 
            180                 185                 190         


Ser Asn Val Thr Asp Asp Thr Tyr Tyr Tyr Arg Arg Arg His Arg His 
        195                 200                 205             


Glu Arg Thr Gln Thr Gln Lys Glu Glu Glu Glu Glu Lys Pro Gln Thr 
    210                 215                 220                 


Thr Tyr Ser Ala Phe Ile Gln Leu Leu Pro Val Leu Val Ile Val Ile 
225                 230                 235                 240 


Ile Ser Val Ile Thr Gln Leu Leu Ala Thr Asn Pro Pro Tyr Ser Leu 
                245                 250                 255     


Phe Tyr Lys Ser Thr Leu Gly Tyr Thr Ile Ser Arg Glu Thr Gln Asn 
            260                 265                 270         


Leu Gln Val Pro Tyr Phe Val Asp Lys Asn Phe Asp Lys Ala Tyr Arg 
        275                 280                 285             


Gly Ala Ser Leu His Asp Leu Glu Lys Thr Ile Glu Lys Asp Tyr Ile 
    290                 295                 300                 


Asp Tyr Ile Gln Thr Ser Cys Trp Lys Glu Lys Gln Gln Lys Ser Glu 
305                 310                 315                 320 


Leu Thr Asn Leu Ala Gly Leu Tyr Arg Asp Glu Arg Leu Lys Gln Lys 
                325                 330                 335     


Ala Glu Ser Leu Lys Leu Glu Asn Cys Glu Lys Leu Ser Lys Leu Ile 
            340                 345                 350         


Gly Leu Arg Arg Gly Gly 
        355             


<210>  8249
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC18__Homo_sapiens__AAH30162

<400>  8249
auggcggcga cucugggcag cggggagcgc uggacggaag cuuacauuga cgcaguuaga       60

agaaacaaau acccagaaga cacaccuccu gagagucaug accccugugg cugcuguaac      120

ugcaugaagg cacaaaagga aaagaagucu gagaaugagu ggacucagac ccggcagggu      180

gaggggaacu ccacguacag ugaggaacag cugcuugggg uacaaaggau caagaaaugc      240

agaaauuacu augaaauucu gggaguuucu cgagaugcua gugacgaaga gcuuaagaaa      300

gcuuacagaa aacucgcccu gaaauuucac ccugacaaga acugugcucc uggagcaaca      360

gaugcuuuca aagcaauagg aaaugcauuu gcaguccuga gcaauccuga uaagagacuu      420

cgcuaugaug aauacggaga ugaacaggug acuuucacug ccccucgagc cagaccuuau      480

aauuauuaca gggauuuuga agcugacauc acuccagaag agcuguucaa cgucuucuuu      540

ggaggacauu uuccuacagg aaauauucau auguuuucaa augugacaga ugacacuuac      600

uauuaccguc gacggcaccg acaugagagg acacagacuc agaaggagga ggaagaagag      660

aaaccucaga cuacauauuc ugcauuuauu cagcuacuuc caguucuugu gauugugauu      720

auaucuguca uuacucagcu gcuggcuacu aaucccccau auagucuguu cuauaaaucg      780

accuugggcu acaccauuuc uagagaaacu cagaaccugc aggugccuua cuuuguggau      840

aaaaacuuug acaaggccua cagaggagcu ucucugcaug acuuggagaa aacaauagag      900

aaggauuaca uugauuauau ccagacuagu uguuggaagg agaaacaaca aaagucagag      960

cugacaaauu uggcaggauu auacagagau gaacgauuga aacagaaagc agagucgcug     1020

aaacuugaaa acugugagaa acuuuccaaa cucauuggcc uacgcagagg uggcuga        1077


<210>  8250
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC18__Homo_sapiens__AAH30162

<400>  8250
auggccgcca cccugggcag cggggagcgc uggaccgagg cguacaucga cgccgugcgg       60

cgcaacaagu accccgagga cacgccgccc gagucccacg accccugcgg cugcugcaac      120

ugcaugaagg cccagaagga gaagaagucc gagaacgagu ggacccagac ccggcagggg      180

gagggcaaca gcaccuacag cgaggagcag cuccuggggg uccagcgcau caagaagugc      240

cggaacuacu acgagauccu gggcgugucc cgcgacgcca gcgacgagga gcucaagaag      300

gccuaccgga agcuggcgcu gaaguuccac cccgacaaga acugcgcccc gggcgccacg      360

gacgccuuca aggcgaucgg gaacgccuuc gccgugcucu ccaaccccga caagcgccug      420

cgguacgacg aguacggcga cgagcagguc accuucaccg cgccccgcgc ccggcccuac      480

aacuacuacc gcgacuucga ggccgacauc accccggagg agcuguucaa cguguucuuc      540

gggggccacu uccccacggg gaacauccac auguucagca acgugaccga cgacaccuac      600

uacuaccggc gccggcaccg ccacgagcgg acccagacgc agaaggagga ggaggaggag      660

aagccccaga ccaccuacuc cgccuucauc cagcuccugc ccguccuggu gaucgugauc      720

aucagcguca ucacccagcu ccuggccacg aacccgcccu acucccuguu cuacaagagc      780

acccucggcu acaccaucuc ccgcgagacc cagaaccucc aggugcccua cuucguggac      840

aagaacuucg acaaggccua ccggggcgcc agccugcacg accuggagaa gacgaucgag      900

aaggacuaca ucgacuacau ccagaccucc ugcuggaagg agaagcagca gaaguccgag      960

cugaccaacc uggcggggcu cuaccgcgac gagcggcuga agcagaaggc cgagagccug     1020

aagcucgaga acugcgagaa gcugagcaag cugaucggcc uccgccgcgg gggcuga        1077


<210>  8251
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC18__Homo_sapiens__AAH30162

<400>  8251
auggccgcca cccucggcuc cggcgagcgc uggaccgagg ccuacaucga cgccguccgc       60

cgcaacaagu accccgagga cacccccccc gagucccacg accccugcgg cugcugcaac      120

ugcaugaagg cccagaagga gaagaagucc gagaacgagu ggacccagac ccgccagggc      180

gagggcaacu ccaccuacuc cgaggagcag cuccucggcg uccagcgcau caagaagugc      240

cgcaacuacu acgagauccu cggcgucucc cgcgacgccu ccgacgagga gcucaagaag      300

gccuaccgca agcucgcccu caaguuccac cccgacaaga acugcgcccc cggcgccacc      360

gacgccuuca aggccaucgg caacgccuuc gccguccucu ccaaccccga caagcgccuc      420

cgcuacgacg aguacggcga cgagcagguc accuucaccg ccccccgcgc ccgccccuac      480

aacuacuacc gcgacuucga ggccgacauc acccccgagg agcucuucaa cgucuucuuc      540

ggcggccacu uccccaccgg caacauccac auguucucca acgucaccga cgacaccuac      600

uacuaccgcc gccgccaccg ccacgagcgc acccagaccc agaaggagga ggaggaggag      660

aagccccaga ccaccuacuc cgccuucauc cagcuccucc ccguccucgu caucgucauc      720

aucuccguca ucacccagcu ccucgccacc aacccccccu acucccucuu cuacaagucc      780

acccucggcu acaccaucuc ccgcgagacc cagaaccucc agguccccua cuucgucgac      840

aagaacuucg acaaggccua ccgcggcgcc ucccuccacg accucgagaa gaccaucgag      900

aaggacuaca ucgacuacau ccagaccucc ugcuggaagg agaagcagca gaaguccgag      960

cucaccaacc ucgccggccu cuaccgcgac gagcgccuca agcagaaggc cgagucccuc     1020

aagcucgaga acugcgagaa gcucuccaag cucaucggcc uccgccgcgg cggcuga        1077


<210>  8252
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC18__Homo_sapiens__AAH30162

<400>  8252
auggccgcua cccugggcag cggggagaga uggacagaag cauacaucga cgccgugagg       60

cggaacaagu aucccgagga uacuccucca gaaucccacg acccgugcgg auguugcaau      120

uguaugaaag cgcagaagga gaaaaagucu gaaaacgagu ggacgcaaac ccgccagggu      180

gagggcaauu caacauacag ugaggaacag cuccuugggg uccagcgaau uaaaaagugc      240

cguaacuauu acgaaauacu gggaguuagc agagaugcuu ccgacgagga guugaagaaa      300

gccuauagga aguuagcacu gaaauuccau cccgauaaga auugugcccc uggcgcuacu      360

gacgcauuua aagccaucgg uaacgcuuuc gccgugcuau cuaauccaga uaagcggcuc      420

cgcuacgacg aauaugggga ugagcaagua accuuuacag cgcccagagc aaggccuuac      480

aacuacuauc gggacuucga agccgauauu accccagagg aacuguuuaa uguguucuuu      540

ggaggccacu uccccacugg caacauccau auguuuucga augucacaga cgauaccuac      600

uauuaccgcc gaagacacag gcaugagcgg acgcagacuc agaaggagga agaggaagag      660

aaaccucaga ccacauauuc agcuuucauu caacuucugc caguguuggu uaucgugaua      720

aucagcguca uuacucagcu ccuggccacc aacccgcccu acagucuguu uuauaagucc      780

acacucgggu acaccaucuc ucgugaaacg cagaauuuac aggugccuua cuucguagac      840

aaaaacuuug acaaggcaua ucgcggagcu agccugcacg aucuugagaa aacuauugag      900

aaggacuaca ucgauuauau acaaacaucc ugcuggaaag aaaagcagca gaagucagag      960

uugaccaauc uggccggucu auacagagac gaaaggcuca aacaaaaggc ggagagucug     1020

aaacuugaaa acugugagaa gcugagcaaa uugauuggcc uccggcgagg gggauga        1077


<210>  8253
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC18__Homo_sapiens__AAH30162

<400>  8253
auggccgcca cccugggcag cggcgagaga uggaccgagg ccuacaucga cgccgugaga       60

agaaacaagu accccgagga cacccccccc gagagccacg accccugcgg cugcugcaac      120

ugcaugaagg cccagaagga gaagaagagc gagaacgagu ggacccagac cagacagggc      180

gagggcaaca gcaccuacag cgaggagcag cugcugggcg ugcagagaau caagaagugc      240

agaaacuacu acgagauccu gggcgugagc agagacgcca gcgacgagga gcugaagaag      300

gccuacagaa agcuggcccu gaaguuccac cccgacaaga acugcgcccc cggcgccacc      360

gacgccuuca aggccaucgg caacgccuuc gccgugcuga gcaaccccga caagagacug      420

agauacgacg aguacggcga cgagcaggug accuucaccg cccccagagc cagacccuac      480

aacuacuaca gagacuucga ggccgacauc acccccgagg agcuguucaa cguguucuuc      540

ggcggccacu uccccaccgg caacauccac auguucagca acgugaccga cgacaccuac      600

uacuacagaa gaagacacag acacgagaga acccagaccc agaaggagga ggaggaggag      660

aagccccaga ccaccuacag cgccuucauc cagcugcugc ccgugcuggu gaucgugauc      720

aucagcguga ucacccagcu gcuggccacc aacccccccu acagccuguu cuacaagagc      780

acccugggcu acaccaucag cagagagacc cagaaccugc aggugcccua cuucguggac      840

aagaacuucg acaaggccua cagaggcgcc agccugcacg accuggagaa gaccaucgag      900

aaggacuaca ucgacuacau ccagaccagc ugcuggaagg agaagcagca gaagagcgag      960

cugaccaacc uggccggccu guacagagac gagagacuga agcagaaggc cgagagccug     1020

aagcuggaga acugcgagaa gcugagcaag cugaucggcc ugagaagagg cggcuga        1077


<210>  8254
<211>  1077
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC18__Homo_sapiens__AAH30162

<400>  8254
auggccgcua cccugggcag cggggagaga uggacagaag ccuacaucga cgcggugcgg       60

cgcaacaagu aucccgagga uacgccuccg gaaucccacg accccugcgg auguugcaau      120

uguaugaaag cucagaagga gaaaaagucu gaaaacgagu ggacccaaac aagacagggc      180

gaggggaaua gcaccuacuc cgaggaacag cuccugggag uccagcggau uaaaaagugc      240

cgcaacuauu acgaaauccu uggcguuucu agagaugcca gcgacgagga gcugaagaaa      300

gccuaucgga agcucgcucu gaaauuccau ccugauaaga auugugcccc cggggcuaca      360

gacgccuuua aagcgauugg aaacgccuuc gcugugcuuu ccaauccuga uaagcgccug      420

agauacgacg aauauggcga ugagcaagug accuuuacag cuccccgggc ccgcccuuac      480

aacuacuaua gagacuucga agccgauauc accccggagg aacucuuuaa ugucuucuuu      540

ggcgggcacu uccccacggg aaacauucau auguuuucua augugaccga cgauacauac      600

uauuaccggc gcagacaccg gcaugagcgc acccagacac agaaggagga agaggaagag      660

aaaccucaga ccacguauag cgcguucauc caacugcugc ccguucucgu gaucgucauu      720

aucuccguga uuacacagcu gcuugccacc aacccucccu acagccuguu uuauaagucu      780

acacucggcu acaccaucuc cagagaaacc cagaaucugc agguuccgua cuucguggac      840

aaaaacuuug acaaggcuua uagaggggcc agccuucacg aucuggagaa aacaauugag      900

aaggacuaca ucgauuauau ucaaacgucu ugcuggaaag aaaagcagca gaaguccgag      960

cucaccaauc uggcuggacu guaccgggac gaacgccuca aacaaaaggc cgagagccug     1020

aaacuugaaa acugugagaa gcugucuaaa cucaucggcc ugcggagagg gggauga        1077


<210>  8255
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC22__Homo_sapiens__Q8N4W6

<400>  8255

Met Ala Lys Gly Leu Leu Val Thr Tyr Ala Leu Trp Ala Val Gly Gly 
1               5                   10                  15      


Pro Ala Gly Leu His His Leu Tyr Leu Gly Arg Asp Ser His Ala Leu 
            20                  25                  30          


Leu Trp Met Leu Thr Leu Gly Gly Gly Gly Leu Gly Trp Leu Trp Glu 
        35                  40                  45              


Phe Trp Lys Leu Pro Ser Phe Val Ala Gln Ala Asn Arg Ala Gln Gly 
    50                  55                  60                  


Gln Arg Gln Ser Pro Arg Gly Val Thr Pro Pro Leu Ser Pro Ile Arg 
65                  70                  75                  80  


Phe Ala Ala Gln Val Ile Val Gly Ile Tyr Phe Gly Leu Val Ala Leu 
                85                  90                  95      


Ile Ser Leu Ser Ser Met Val Asn Phe Tyr Ile Val Ala Leu Pro Leu 
            100                 105                 110         


Ala Val Gly Leu Gly Val Leu Leu Val Ala Ala Val Gly Asn Gln Thr 
        115                 120                 125             


Ser Asp Phe Lys Asn Thr Leu Gly Ser Ala Phe Leu Thr Ser Pro Ile 
    130                 135                 140                 


Phe Tyr Gly Arg Pro Ile Ala Ile Leu Pro Ile Ser Val Ala Ala Ser 
145                 150                 155                 160 


Ile Thr Ala Gln Arg His Arg Arg Tyr Lys Ala Leu Val Ala Ser Glu 
                165                 170                 175     


Pro Leu Ser Val Arg Leu Tyr Arg Leu Gly Leu Ala Tyr Leu Ala Phe 
            180                 185                 190         


Thr Gly Pro Leu Ala Tyr Ser Ala Leu Cys Asn Thr Ala Ala Thr Leu 
        195                 200                 205             


Ser Tyr Val Ala Glu Thr Phe Gly Ser Phe Leu Asn Trp Phe Ser Phe 
    210                 215                 220                 


Phe Pro Leu Leu Gly Arg Leu Met Glu Phe Val Leu Leu Leu Pro Tyr 
225                 230                 235                 240 


Arg Ile Trp Arg Leu Leu Met Gly Glu Thr Gly Phe Asn Ser Ser Cys 
                245                 250                 255     


Phe Gln Glu Trp Ala Lys Leu Tyr Glu Phe Val His Ser Phe Gln Asp 
            260                 265                 270         


Glu Lys Arg Gln Leu Ala Tyr Gln Val Leu Gly Leu Ser Glu Gly Ala 
        275                 280                 285             


Thr Asn Glu Glu Ile His Arg Ser Tyr Gln Glu Leu Val Lys Val Trp 
    290                 295                 300                 


His Pro Asp His Asn Leu Asp Gln Thr Glu Glu Ala Gln Arg His Phe 
305                 310                 315                 320 


Leu Glu Ile Gln Ala Ala Tyr Glu Val Leu Ser Gln Pro Arg Lys Pro 
                325                 330                 335     


Trp Gly Ser Arg Arg 
            340     


<210>  8256
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC22__Homo_sapiens__AAH33236

<400>  8256
auggccaagg ggcuccuggu gaccuaugcc cucugggcug uggggggccc ugcugggcuc       60

caccaccugu accugggaag ggacagccac gcccugcucu ggaugcugac ccugggggga      120

ggugggcugg gcuggcucug ggaguucugg aagcucccaa gcuuuguagc ucaggccaac      180

agagcccagg gacagaggca gagccccaga ggggugacac ccccucugag ucccauucgc      240

uuugcugccc aggugauagu uggcaucuau uuuggccuug uggcacugau uagccuuucu      300

uccaugguca acuucuauau uguggcccuc ccacuggcag uuggcuuagg ggucuugcug      360

guggcugcug uuggcaacca gaccucagac uuuaagaaca cucugggguc agcauuucuc      420

acuucaccua ucuucuaugg ccgccccaua gccauacugc ccauuagcgu ggccgccagc      480

auuacagcuc agaggcaucg ccgcuacaaa gcuuuggugg caucagagcc gcucagugug      540

cggcucuauc gucugggcuu ggcuuaccuu gcuuucacag gcccacuggc auacagugcc      600

cucugcaaca cagcugccac ccucagcuau guggcagaaa ccuuuggcuc cuucuugaau      660

ugguucagcu ucuucccccu ucuuggccgc cucauggagu uuguccuccu ucugccuuac      720

cggaucugga ggcuacugau gggggagacu ggcuucaaca gcagcugcuu ucaggagugg      780

gcgaagcucu augaguuugu ucacaguuuu caggaugaga agcgucagcu ggcuuaccag      840

guuuugggcc ucucagaagg ggcaacaaau gaagaaauac aucggaguua ccaggagcua      900

gugaaggucu ggcacccaga ccacaaccug gaccagacag aggaggcaca gaggcacuuc      960

cuggagaucc aggcugcgua ugaaguccug agucaaccca ggaagcccug gggaucccgg     1020

agguga                                                                1026


<210>  8257
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC22__Homo_sapiens__AAH33236

<400>  8257
auggccaagg gccugcucgu gaccuacgcc cugugggcgg ucgggggccc cgccgggcug       60

caccaccucu accugggccg cgacagccac gcccugcucu ggaugcugac ccucgggggc      120

ggcgggcugg gcuggcugug ggaguucugg aagcugccgu ccuucguggc ccaggccaac      180

cgggcgcagg ggcagcgcca gagcccccgg ggcgugacgc cgccccucuc ccccauccgc      240

uucgccgccc aggucaucgu ggggaucuac uucggccugg uggcccugau cagccucucc      300

agcaugguca acuucuacau cguggcgcug ccccuggccg ugggccucgg gguccugcug      360

guggccgccg ugggcaacca gaccuccgac uucaagaaca cccucgggag cgccuuccug      420

accuccccca ucuucuacgg ccggcccauc gcgauccugc cgaucagcgu cgccgccucc      480

aucacggccc agcgccaccg gcgcuacaag gcccucgugg cgagcgagcc ccuguccgug      540

cggcuguacc gccucggccu ggccuaccug gccuucaccg ggccccucgc cuacagcgcc      600

cugugcaaca ccgcggccac ccuguccuac gucgccgaga cguucggcag cuuccucaac      660

ugguucuccu ucuucccccu gcuggggcgg cucauggagu ucgugcugcu gcucccguac      720

cgcaucuggc ggcugcugau gggcgagacc ggguucaaca gcuccugcuu ccaggagugg      780

gccaagcucu acgaguucgu gcacagcuuc caggacgaga agcgccagcu ggccuaccag      840

guccugggcc ucagcgaggg cgcgaccaac gaggagaucc accgguccua ccaggagcug      900

gugaaggugu ggcaccccga ccacaaccug gaccagaccg aggaggccca gcgccacuuc      960

cucgagaucc aggccgccua cgagguccug agccagcccc ggaagcccug ggggucccgc     1020

cgguga                                                                1026


<210>  8258
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC22__Homo_sapiens__AAH33236

<400>  8258
auggccaagg gccuccucgu caccuacgcc cucugggccg ucggcggccc cgccggccuc       60

caccaccucu accucggccg cgacucccac gcccuccucu ggaugcucac ccucggcggc      120

ggcggccucg gcuggcucug ggaguucugg aagcuccccu ccuucgucgc ccaggccaac      180

cgcgcccagg gccagcgcca guccccccgc ggcgucaccc ccccccucuc ccccauccgc      240

uucgccgccc aggucaucgu cggcaucuac uucggccucg ucgcccucau cucccucucc      300

uccaugguca acuucuacau cgucgcccuc ccccucgccg ucggccucgg cguccuccuc      360

gucgccgccg ucggcaacca gaccuccgac uucaagaaca cccucggcuc cgccuuccuc      420

accuccccca ucuucuacgg ccgccccauc gccauccucc ccaucuccgu cgccgccucc      480

aucaccgccc agcgccaccg ccgcuacaag gcccucgucg ccuccgagcc ccucuccguc      540

cgccucuacc gccucggccu cgccuaccuc gccuucaccg gcccccucgc cuacuccgcc      600

cucugcaaca ccgccgccac ccucuccuac gucgccgaga ccuucggcuc cuuccucaac      660

ugguucuccu ucuucccccu ccucggccgc cucauggagu ucguccuccu ccuccccuac      720

cgcaucuggc gccuccucau gggcgagacc ggcuucaacu ccuccugcuu ccaggagugg      780

gccaagcucu acgaguucgu ccacuccuuc caggacgaga agcgccagcu cgccuaccag      840

guccucggcc ucuccgaggg cgccaccaac gaggagaucc accgcuccua ccaggagcuc      900

gucaaggucu ggcaccccga ccacaaccuc gaccagaccg aggaggccca gcgccacuuc      960

cucgagaucc aggccgccua cgagguccuc ucccagcccc gcaagcccug gggcucccgc     1020

cgcuga                                                                1026


<210>  8259
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC22__Homo_sapiens__AAH33236

<400>  8259
auggccaagg gccugcucgu gaccuacgcu cuuugggcag ucgggggacc cgccggucug       60

caccauuugu auuuaggcag agacagccac gcgcugcuau ggaugcucac acuuggggga      120

ggcggucugg gguggcugug ggaguucugg aaauugccuu ccuuuguugc ucaggccaac      180

agggcacaag gacagcggca gucuccacgc ggcgugacuc cgccccucuc accuauccga      240

uucgccgcuc agguaauugu gggcauauac uuugggcugg ucgcacugau cagucucagc      300

uccaugguga auuucuauau uguugccuua ccacuggcug ugggacuugg ugucuugcug      360

guggccgcgg uaggcaacca aacgucugau uuuaagaaua cccuaggguc ggcauuccuc      420

acaucaccca ucuuuuacgg acguccuauu gccauccugc caauaagcgu ugcugccagu      480

aucacugcac agagacauag gcgguauaaa gcucuugugg ccuccgaacc ccugucuguc      540

cgcuuguaca gacucggccu ggcguauuua gccuucaccg guccucuggc auacagcgcu      600

cucugcaaca cagccgcuac ccuuuccuac guggccgaga cuuuuggguc auuccugaau      660

ugguuuaguu ucuuuccauu gcuaggaagg cugauggagu ucgugcuccu gcuuccguau      720

cggauuuggc gccuguugau gggcgaaaca ggcuucaaca gcucuuguuu ucaggaaugg      780

gcaaagcucu acgaguucgu ccacuccuuu caggacgaga aacgacaacu ggccuaucag      840

guuuuagggc ugucagaagg agcuaccaau gaggaaaucc auagaagcua ccaggagcua      900

gugaagguau ggcaccccga ucacaaccuc gaccagacgg aggaagcgca aaggcauuuc      960

cuggagauuc aggcagccua ugaagugcuu agucagccuc ggaagccaug ggguucucgu     1020

cgcuga                                                                1026


<210>  8260
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC22__Homo_sapiens__AAH33236

<400>  8260
auggccaagg gccugcuggu gaccuacgcc cugugggccg ugggcggccc cgccggccug       60

caccaccugu accugggcag agacagccac gcccugcugu ggaugcugac ccugggcggc      120

ggcggccugg gcuggcugug ggaguucugg aagcugccca gcuucguggc ccaggccaac      180

agagcccagg gccagagaca gagccccaga ggcgugaccc ccccccugag ccccaucaga      240

uucgccgccc aggugaucgu gggcaucuac uucggccugg uggcccugau cagccugagc      300

agcaugguga acuucuacau cguggcccug ccccuggccg ugggccuggg cgugcugcug      360

guggccgccg ugggcaacca gaccagcgac uucaagaaca cccugggcag cgccuuccug      420

accagcccca ucuucuacgg cagacccauc gccauccugc ccaucagcgu ggccgccagc      480

aucaccgccc agagacacag aagauacaag gcccuggugg ccagcgagcc ccugagcgug      540

agacuguaca gacugggccu ggccuaccug gccuucaccg gcccccuggc cuacagcgcc      600

cugugcaaca ccgccgccac ccugagcuac guggccgaga ccuucggcag cuuccugaac      660

ugguucagcu ucuucccccu gcugggcaga cugauggagu ucgugcugcu gcugcccuac      720

agaaucugga gacugcugau gggcgagacc ggcuucaaca gcagcugcuu ccaggagugg      780

gccaagcugu acgaguucgu gcacagcuuc caggacgaga agagacagcu ggccuaccag      840

gugcugggcc ugagcgaggg cgccaccaac gaggagaucc acagaagcua ccaggagcug      900

gugaaggugu ggcaccccga ccacaaccug gaccagaccg aggaggccca gagacacuuc      960

cuggagaucc aggccgccua cgaggugcug agccagccca gaaagcccug gggcagcaga     1020

agauga                                                                1026


<210>  8261
<211>  1026
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC22__Homo_sapiens__AAH33236

<400>  8261
auggccaagg gccugcucgu gaccuacgcu cugugggccg ucgggggacc cgcgggccuu       60

caccaucugu aucucgggag agacagccac gcucugcuuu ggaugcugac acucggaggc      120

gggggacugg gcuggcugug ggaguucugg aaacucccuu ccuuuguugc ccaggccaac      180

cgggcucaag gccagcgcca gucuccgaga ggggugacgc ccccucugag ccccauccgg      240

uucgccgcuc aggugauugu cggaaucuac uuuggccuug uggcccugau uucccucucu      300

agcaugguua auuucuauau cguggcgcug ccucuugccg ucgggcuggg agugcuccug      360

guugcugccg ugggcaacca aaccuccgau uuuaagaaua cacugggguc ugcuuuccuc      420

accagcccca uuuucuacgg acgcccuauc gccauccugc cgauuuccgu cgcggccagc      480

aucacagcuc agagacaucg gcgcuauaaa gcccuugugg cuucugaacc ccuguccgug      540

agacucuacc ggcugggccu ugccuaucug gccuucaccg gcccucucgc uuacagcgcg      600

cugugcaaca cagccgcuac ccugucuuac gucgccgaga cguuuggguc cuuccucaau      660

ugguuuagcu ucuuuccccu gcuuggacgc cugauggaau uuguucuccu gcuuccuuau      720

agaauuuggc ggcugcucau gggcgagacc ggguucaacu cuuccuguuu ucaggaaugg      780

gccaagcugu acgaguucgu gcacagcuuu caggacgaga aacgccaacu ggcuuaucag      840

gugcucggac uguccgaagg cgccacaaau gaggaaaucc auagaucuua ccaggagcuu      900

gucaaggugu ggcaccccga ucacaaccug gaccagaccg aggaagcgca acggcauuuc      960

cucgagauuc aggcugccua ugaaguucug agccagccgc gcaagccuug gggguccaga     1020

cgguga                                                                1026


<210>  8262
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC24__Homo_sapiens__Q6P3W2

<400>  8262

Met Ala Val Glu Gln Met Pro Lys Lys Asp Trp Tyr Ser Ile Leu Gly 
1               5                   10                  15      


Ala Asp Pro Ser Ala Asn Ile Ser Asp Leu Lys Gln Lys Tyr Gln Lys 
            20                  25                  30          


Leu Ile Leu Met Tyr His Pro Asp Lys Gln Ser Thr Asp Val Pro Ala 
        35                  40                  45              


Gly Thr Val Glu Glu Cys Val Gln Lys Phe Ile Glu Ile Asp Gln Ala 
    50                  55                  60                  


Trp Lys Ile Leu Gly Asn Glu Glu Thr Lys Arg Glu Tyr Asp Leu Gln 
65                  70                  75                  80  


Arg Cys Glu Asp Asp Leu Arg Asn Val Gly Pro Val Asp Ala Gln Val 
                85                  90                  95      


Tyr Leu Glu Glu Met Ser Trp Asn Glu Gly Asp His Ser Phe Tyr Leu 
            100                 105                 110         


Ser Cys Arg Cys Gly Gly Lys Tyr Ser Val Ser Lys Asp Glu Ala Glu 
        115                 120                 125             


Glu Val Ser Leu Ile Ser Cys Asp Thr Cys Ser Leu Ile Ile Glu Leu 
    130                 135                 140                 


Leu His Tyr Asn 
145             


<210>  8263
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC24__Homo_sapiens__AAH63804

<400>  8263
auggcgguug agcagaugcc aaaaaaggau ugguacagca uccugggagc agacccaucu       60

gcaaauauau cagaccuaaa acaaaaauau caaaaacuca uauuaaugua ucauccagau      120

aaacaaagua cagauguacc agcaggaaca guggaggaau guguacagaa guucaucgaa      180

auugaucaag cauggaaaau ucuaggaaau gaagagacaa aaagagagua ugaccugcag      240

cggugugaag augaucuaag aaauguagga ccaguagaug cucaaguaua ucuugaagaa      300

augucuugga augaagguga ucacucuuuu uaucugaguu gcagaugugg uggaaaauac      360

aguguuucca aggaugaagc ggaagaaguu agccugauuu cuugugauac auguucacua      420

auuauagaac uccuucauua uaacuaa                                          447


<210>  8264
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC24__Homo_sapiens__AAH63804

<400>  8264
auggccgugg agcagaugcc caagaaggac ugguacagca uccugggcgc cgacccgucc       60

gcgaacauca gcgaccucaa gcagaaguac cagaagcuga uccugaugua ccaccccgac      120

aagcagucca ccgacguccc cgccgggacc guggaggagu gcgugcagaa guucaucgag      180

aucgaccagg ccuggaagau ccucggcaac gaggagacca agcgcgagua cgaccugcag      240

cggugcgagg acgaccugcg caacgucggg cccguggacg cccaggugua ccucgaggag      300

augagcugga acgagggcga ccacuccuuc uaccugagcu gccggugcgg gggcaaguac      360

uccgucagca aggacgaggc cgaggaggug ucccugauca gcugcgacac gugcucccuc      420

aucaucgagc ugcugcacua caacuga                                          447


<210>  8265
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC24__Homo_sapiens__AAH63804

<400>  8265
auggccgucg agcagaugcc caagaaggac ugguacucca uccucggcgc cgaccccucc       60

gccaacaucu ccgaccucaa gcagaaguac cagaagcuca uccucaugua ccaccccgac      120

aagcagucca ccgacguccc cgccggcacc gucgaggagu gcguccagaa guucaucgag      180

aucgaccagg ccuggaagau ccucggcaac gaggagacca agcgcgagua cgaccuccag      240

cgcugcgagg acgaccuccg caacgucggc cccgucgacg cccaggucua ccucgaggag      300

auguccugga acgagggcga ccacuccuuc uaccucuccu gccgcugcgg cggcaaguac      360

uccgucucca aggacgaggc cgaggagguc ucccucaucu ccugcgacac cugcucccuc      420

aucaucgagc uccuccacua caacuga                                          447


<210>  8266
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC24__Homo_sapiens__AAH63804

<400>  8266
auggccgugg agcagaugcc caagaaagac ugguacagca uccugggcgc ugauccuucc       60

gcaaacauuu cugaccucaa gcaaaaauau cagaaacuua uacugaugua ccacccagau      120

aagcagucaa ccgacguccc ggccgggaca guugaagagu gcgugcagaa guucaucgaa      180

auugaucaag cguggaagau cuugggaaau gaggaaacua aaagagagua ugacuuacag      240

aggugugagg augaccugcg gaacguaggu cccguggaug cucaggucua ccuagaagag      300

augaguugga augaaggcga ccauagcuuu uaucucuccu gccgcugugg gggaaaguac      360

ucugugucga aagaugaggc cgaggaaguu ucacugauua gcugcgacac guguagucuu      420

aucauagagc uguugcacua uaacuga                                          447


<210>  8267
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC24__Homo_sapiens__AAH63804

<400>  8267
auggccgugg agcagaugcc caagaaggac ugguacagca uccugggcgc cgaccccagc       60

gccaacauca gcgaccugaa gcagaaguac cagaagcuga uccugaugua ccaccccgac      120

aagcagagca ccgacgugcc cgccggcacc guggaggagu gcgugcagaa guucaucgag      180

aucgaccagg ccuggaagau ccugggcaac gaggagacca agagagagua cgaccugcag      240

agaugcgagg acgaccugag aaacgugggc cccguggacg cccaggugua ccuggaggag      300

augagcugga acgagggcga ccacagcuuc uaccugagcu gcagaugcgg cggcaaguac      360

agcgugagca aggacgaggc cgaggaggug agccugauca gcugcgacac cugcagccug      420

aucaucgagc ugcugcacua caacuga                                          447


<210>  8268
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC24__Homo_sapiens__AAH63804

<400>  8268
auggccgugg agcagaugcc caagaaagac ugguacagca uccugggcgc ugauccuucc       60

gccaacauuu cugaccucaa gcaaaaauau cagaagcuga uccuuaugua ccacccggau      120

aaacagagca ccgacguccc cgcggggaca guugaagagu gcgugcagaa guucauugaa      180

aucgaucagg cuuggaagau ucugggaaau gaggaaacga aaagagagua ugaccuccaa      240

cggugugagg augaccugcg caacgugggc ccugucgaug cccaggugua ccuugaagag      300

auguccugga augaagggga ccauucuuuu uaucugagcu gcagaugugg aggcaaguac      360

uccguuucua aagaugaggc cgaggaagug agccucaucu ccugcgacac cuguagccug      420

aucauugagc ugcuccacua uaacuga                                          447


<210>  8269
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC25__Homo_sapiens__Q9H1X3

<400>  8269

Met Gly Ala Pro Leu Leu Ser Pro Gly Trp Gly Ala Gly Ala Ala Gly 
1               5                   10                  15      


Arg Arg Trp Trp Met Leu Leu Ala Pro Leu Leu Pro Ala Leu Leu Leu 
            20                  25                  30          


Val Arg Pro Ala Gly Ala Leu Val Glu Gly Leu Tyr Cys Gly Thr Arg 
        35                  40                  45              


Asp Cys Tyr Glu Val Leu Gly Val Ser Arg Ser Ala Gly Lys Ala Glu 
    50                  55                  60                  


Ile Ala Arg Ala Tyr Arg Gln Leu Ala Arg Arg Tyr His Pro Asp Arg 
65                  70                  75                  80  


Tyr Arg Pro Gln Pro Gly Asp Glu Gly Pro Gly Arg Thr Pro Gln Ser 
                85                  90                  95      


Ala Glu Glu Ala Phe Leu Leu Val Ala Thr Ala Tyr Glu Thr Leu Lys 
            100                 105                 110         


Asp Glu Glu Thr Arg Lys Asp Tyr Asp Tyr Met Leu Asp His Pro Glu 
        115                 120                 125             


Glu Tyr Tyr Ser His Tyr Tyr His Tyr Tyr Ser Arg Arg Leu Ala Pro 
    130                 135                 140                 


Lys Val Asp Val Arg Val Val Ile Leu Val Ser Val Cys Ala Ile Ser 
145                 150                 155                 160 


Val Phe Gln Phe Phe Ser Trp Trp Asn Ser Tyr Asn Lys Ala Ile Ser 
                165                 170                 175     


Tyr Leu Ala Thr Val Pro Lys Tyr Arg Ile Gln Ala Thr Glu Ile Ala 
            180                 185                 190         


Lys Gln Gln Gly Leu Leu Lys Lys Ala Lys Glu Lys Gly Lys Asn Lys 
        195                 200                 205             


Lys Ser Lys Glu Glu Ile Arg Asp Glu Glu Glu Asn Ile Ile Lys Asn 
    210                 215                 220                 


Ile Ile Lys Ser Lys Ile Asp Ile Lys Gly Gly Tyr Gln Lys Pro Gln 
225                 230                 235                 240 


Ile Cys Asp Leu Leu Leu Phe Gln Ile Ile Leu Ala Pro Phe His Leu 
                245                 250                 255     


Cys Ser Tyr Ile Val Trp Tyr Cys Arg Trp Ile Tyr Asn Phe Asn Ile 
            260                 265                 270         


Lys Gly Lys Glu Tyr Gly Glu Glu Glu Arg Leu Tyr Ile Ile Arg Lys 
        275                 280                 285             


Ser Met Lys Met Ser Lys Ser Gln Phe Asp Ser Leu Glu Asp His Gln 
    290                 295                 300                 


Lys Glu Thr Phe Leu Lys Arg Glu Leu Trp Ile Lys Glu Asn Tyr Glu 
305                 310                 315                 320 


Val Tyr Lys Gln Glu Gln Glu Glu Glu Leu Lys Lys Lys Leu Ala Asn 
                325                 330                 335     


Asp Pro Arg Trp Lys Arg Tyr Arg Arg Trp Met Lys Asn Glu Gly Pro 
            340                 345                 350         


Gly Arg Leu Thr Phe Val Asp Asp 
        355                 360 


<210>  8270
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC25__Homo_sapiens__AAH48318

<400>  8270
augggggcgc cgcugcucuc ucccggcugg ggagccgggg cugccggccg gcgcuggugg       60

augcugcugg cgccccugcu gccggcgcug cugcuggugc ggcccgcggg ggcccuggug      120

gaggggcucu acugcggcac gcgggacugc uacgaggugc ugggcgugag ccgcucggcg      180

ggcaaggcgg agaucgcgcg ggccuaccgc cagcuggccc ggcgcuacca cccugaccgc      240

uaccggcccc agcccggaga cgagggcccc gggcggacgc cgcagagcgc cgaggaggcu      300

uuccugcugg uggcaaccgc cuacgagaca cucaaggaug aagaaacacg aaaagauuau      360

gauuacaugc uggaucaucc agaagaguac uacagccauu acuaccacua cuauagcagg      420

cgcuuggccc cuaaggugga uguuagagua gugauuuugg ucagcgugug ugcuauuucg      480

guguuucagu uuuucagcug guggaauagc uacaauaagg caaucagcua ccuagccaca      540

gugcccaagu accguaucca agcuacagag auugccaagc agcagggacu gcucaaaaaa      600

gccaaagaaa aaggcaaaaa caaaaagucc aaagaagaaa uucgugacga ggaggagaac      660

aucauaaaga acauuauaaa aaguaaaaua gauauaaagg ggggcuauca gaaaccccaa      720

aucugugauc uucuccuguu ucaaauuauc uuagcuccuu uucaccuaug cucauauaua      780

guuugguauu gucgguggau cuauaauuuu aacaucaaag gcaaagaaua uggagaggaa      840

gagagauuau acauuauacg uaaaucuaug aagaugucaa agucucaauu ugauagucua      900

gaagaucauc agaaagaaac uuuucuuaaa cgagagcucu ggaucaagga gaauuaugag      960

gucuacaagc aagaacaaga ggaagaauua aagaaaaagu uggcaaauga ccccagaugg     1020

aagagauaca ggagauggau gaagaaugaa gggccugggc gguuaacauu ugucgaugac     1080

uga                                                                   1083


<210>  8271
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC25__Homo_sapiens__AAH48318

<400>  8271
augggcgcgc cccugcucag cccggggugg ggcgccgggg ccgccggccg ccgguggugg       60

augcugcugg cgccccuccu gcccgcccug cuccuggugc gccccgccgg ggcccugguc      120

gagggccucu acugcggcac ccgggacugc uacgaggugc uggggguguc ccgcagcgcc      180

ggcaaggccg agaucgcccg ggcguaccgc cagcuggccc ggcgcuacca cccggaccgg      240

uaccgccccc agcccgggga cgagggcccc gggcggaccc cgcaguccgc cgaggaggcc      300

uuccuccugg ucgccacggc guacgagacc cugaaggacg aggagacccg caaggacuac      360

gacuacaugc ucgaccaccc cgaggaguac uacagccacu acuaccacua cuacucccgg      420

cgccuggccc ccaaggugga cgugcggguc gugauccugg ugagcgucug cgccaucucc      480

guguuccagu ucuucagcug guggaacucc uacaacaagg ccaucagcua ccucgccacc      540

gugcccaagu accgcaucca ggcgacggag aucgccaagc agcagggccu gcugaagaag      600

gccaaggaga agggcaagaa caagaagucc aaggaggaga uccgggacga ggaggagaac      660

aucaucaaga acaucaucaa gagcaagauc gacaucaagg gcggguacca gaagccgcag      720

aucugcgacc uccugcuguu ccagaucauc cucgcccccu uccaccugug cuccuacauc      780

gucugguacu gccgcuggau cuacaacuuc aacaucaagg ggaaggagua cggcgaggag      840

gagcggcugu acaucauccg caagagcaug aagaugucca agagccaguu cgacucccuc      900

gaggaccacc agaaggagac cuuccugaag cgggagcugu ggaucaagga gaacuacgag      960

guguacaagc aggagcagga ggaggagcuc aagaagaagc uggccaacga cccccgcugg     1020

aagcgcuacc ggcgcuggau gaagaacgag ggccccgggc ggcugaccuu cguggacgac     1080

uga                                                                   1083


<210>  8272
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC25__Homo_sapiens__AAH48318

<400>  8272
augggcgccc cccuccucuc ccccggcugg ggcgccggcg ccgccggccg ccgcuggugg       60

augcuccucg ccccccuccu ccccgcccuc cuccucgucc gccccgccgg cgcccucguc      120

gagggccucu acugcggcac ccgcgacugc uacgaggucc ucggcgucuc ccgcuccgcc      180

ggcaaggccg agaucgcccg cgccuaccgc cagcucgccc gccgcuacca ccccgaccgc      240

uaccgccccc agcccggcga cgagggcccc ggccgcaccc cccaguccgc cgaggaggcc      300

uuccuccucg ucgccaccgc cuacgagacc cucaaggacg aggagacccg caaggacuac      360

gacuacaugc ucgaccaccc cgaggaguac uacucccacu acuaccacua cuacucccgc      420

cgccucgccc ccaaggucga cguccgcguc gucauccucg ucuccgucug cgccaucucc      480

gucuuccagu ucuucuccug guggaacucc uacaacaagg ccaucuccua ccucgccacc      540

guccccaagu accgcaucca ggccaccgag aucgccaagc agcagggccu ccucaagaag      600

gccaaggaga agggcaagaa caagaagucc aaggaggaga uccgcgacga ggaggagaac      660

aucaucaaga acaucaucaa guccaagauc gacaucaagg gcggcuacca gaagccccag      720

aucugcgacc uccuccucuu ccagaucauc cucgcccccu uccaccucug cuccuacauc      780

gucugguacu gccgcuggau cuacaacuuc aacaucaagg gcaaggagua cggcgaggag      840

gagcgccucu acaucauccg caaguccaug aagaugucca agucccaguu cgacucccuc      900

gaggaccacc agaaggagac cuuccucaag cgcgagcucu ggaucaagga gaacuacgag      960

gucuacaagc aggagcagga ggaggagcuc aagaagaagc ucgccaacga cccccgcugg     1020

aagcgcuacc gccgcuggau gaagaacgag ggccccggcc gccucaccuu cgucgacgac     1080

uga                                                                   1083


<210>  8273
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC25__Homo_sapiens__AAH48318

<400>  8273
augggcgcuc cccugcucag cccugggugg ggagccggug cagccggcag aagguggugg       60

augcuucugg cgccauuguu accggcucug cuacucgugc ggcccgccgg ggcacugguc      120

gagggacuuu acugcggcac ccgcgacugu uaugaaguuc uggguguguc ccgaucugcc      180

gggaaggcug agaucgcacg ugccuacaga caguuggcua ggcgguauca cccugaucgc      240

uacagaccac aacccggaga cgaaggcccu ggcaggacac cacagucagc cgaggaagcg      300

uuccuccugg uagcaacugc cuaugagacg cugaaagaug aggaaacccg gaaggacuac      360

gauuauaugc ucgaccaucc cgaggaauac uacagucacu auuaccauua uuacagccgc      420

cgauuagcuc cuaaagugga ugucagagug guuauucugg uguccgucug cgccauaucu      480

guguuucagu ucuuuucgug guggaacuca uauaauaagg caaucagcua ccuugcuaca      540

guaccaaaau auaggauuca ggccacugag aucgcgaagc aacagggguu gcugaagaaa      600

gccaaggaga aaggaaagaa caaaaagagu aaggaagaga uucgggacga agaggaaaau      660

aucaucaaaa acauaauuaa guccaaaauc gauauuaagg guggcuacca gaaaccgcag      720

aucugugacc uacuccuguu ccaaauaauu cuugcacccu uucaccugug cucuuacauc      780

guuugguauu gucguuggau uuacaauuuc aacaucaagg ggaaagagua uggagaggaa      840

gaacgcuugu acaucauuag aaagagcaug aagaugucca aaucacaguu ugauagucuc      900

gaagaccauc agaaggagac cuuccugaaa agggaauuau ggauaaagga gaauuaugag      960

guguacaaac aggaacaaga ggaggagcug aagaagaaac ucgcuaacga uccucggugg     1020

aagcgauauc gcagauggau gaaaaaugaa ggcccaggua ggcuuacauu ugucgacgac     1080

uga                                                                   1083


<210>  8274
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC25__Homo_sapiens__AAH48318

<400>  8274
augggcgccc cccugcugag ccccggcugg ggcgccggcg ccgccggcag aagauggugg       60

augcugcugg ccccccugcu gcccgcccug cugcugguga gacccgccgg cgcccuggug      120

gagggccugu acugcggcac cagagacugc uacgaggugc ugggcgugag cagaagcgcc      180

ggcaaggccg agaucgccag agccuacaga cagcuggcca gaagauacca ccccgacaga      240

uacagacccc agcccggcga cgagggcccc ggcagaaccc cccagagcgc cgaggaggcc      300

uuccugcugg uggccaccgc cuacgagacc cugaaggacg aggagaccag aaaggacuac      360

gacuacaugc uggaccaccc cgaggaguac uacagccacu acuaccacua cuacagcaga      420

agacuggccc ccaaggugga cgugagagug gugauccugg ugagcgugug cgccaucagc      480

guguuccagu ucuucagcug guggaacagc uacaacaagg ccaucagcua ccuggccacc      540

gugcccaagu acagaaucca ggccaccgag aucgccaagc agcagggccu gcugaagaag      600

gccaaggaga agggcaagaa caagaagagc aaggaggaga ucagagacga ggaggagaac      660

aucaucaaga acaucaucaa gagcaagauc gacaucaagg gcggcuacca gaagccccag      720

aucugcgacc ugcugcuguu ccagaucauc cuggcccccu uccaccugug cagcuacauc      780

gugugguacu gcagauggau cuacaacuuc aacaucaagg gcaaggagua cggcgaggag      840

gagagacugu acaucaucag aaagagcaug aagaugagca agagccaguu cgacagccug      900

gaggaccacc agaaggagac cuuccugaag agagagcugu ggaucaagga gaacuacgag      960

guguacaagc aggagcagga ggaggagcug aagaagaagc uggccaacga ccccagaugg     1020

aagagauaca gaagauggau gaagaacgag ggccccggca gacugaccuu cguggacgac     1080

uga                                                                   1083


<210>  8275
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC25__Homo_sapiens__AAH48318

<400>  8275
augggcgcuc cccugcucag cccugggugg ggagccggcg ccgcggggag acgguggugg       60

augcugcuug cuccgcugcu ccccgcccug cuucuggugc gcccugccgg agcucucguc      120

gagggccugu acugcgggac cagagacugu uaugaaguuc ugggaguguc ccggucugcc      180

ggcaaggcug agaucgcccg cgcguacaga cagcucgccc ggcgcuauca ccccgauaga      240

uaccggccuc aacccggcga cgaagggccu ggacgcacac cgcagagcgc ugaggaagcc      300

uuccugcuug uggcuacggc cuaugagacc cugaaagaug aggaaacaag aaaggacuac      360

gauuauaugc ucgaccaucc cgaggaauac uacucccacu auuaccauua uuacucucgg      420

cgccuggcgc cuaaagucga ugugagaguu gugauucuug ucagcgugug cgccaucucc      480

guuuuucagu ucuuuucuug guggaacagc uauaauaagg cuauuuccua ccuggccacc      540

gugcccaaau aucggaucca ggcuacagag auugccaagc aacagggccu ccugaagaaa      600

gccaaggaga aagggaagaa caaaaagagc aaggaagaga uccgcgacga agaggaaaau      660

aucauuaaaa acaucauuaa gucuaaaauc gauauuaagg gaggcuacca gaaaccucag      720

aucugugacc ugcuccuguu ccaaauuauc cuugcucccu uucaccugug cuccuacauc      780

gucugguauu guagauggau uuacaauuuc aacaucaagg ggaaagagua uggagaggaa      840

gaacggcucu acauuaucag aaagagcaug aagaugucua aaucccaguu ugauagccug      900

gaagaccauc agaaggagac cuuccuuaaa cgcgaacugu ggauuaagga gaauuaugag      960

guguacaaac aggaacaaga ggaggagcuc aagaagaaac uggcgaacga uccgcggugg     1020

aagagauauc gccgguggau gaaaaaugaa ggcccuggca gacugacauu uguggacgac     1080

uga                                                                   1083


<210>  8276
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC27__Homo_sapiens__Q9NZQ0

<400>  8276

Met Glu Ala Asn Met Pro Lys Arg Lys Glu Pro Gly Arg Ser Leu Arg 
1               5                   10                  15      


Ile Lys Val Ile Ser Met Gly Asn Ala Glu Val Gly Lys Ser Cys Ile 
            20                  25                  30          


Ile Lys Arg Tyr Cys Glu Lys Arg Phe Val Ser Lys Tyr Leu Ala Thr 
        35                  40                  45              


Ile Gly Ile Asp Tyr Gly Val Thr Lys Val His Val Arg Asp Arg Glu 
    50                  55                  60                  


Ile Lys Val Asn Ile Phe Asp Met Ala Gly His Pro Phe Phe Tyr Glu 
65                  70                  75                  80  


Val Arg Asn Glu Phe Tyr Lys Asp Thr Gln Gly Val Ile Leu Val Tyr 
                85                  90                  95      


Asp Val Gly Gln Lys Asp Ser Phe Asp Ala Leu Asp Ala Trp Leu Ala 
            100                 105                 110         


Glu Met Lys Gln Glu Leu Gly Pro His Gly Asn Met Glu Asn Ile Ile 
        115                 120                 125             


Phe Val Val Cys Ala Asn Lys Ile Asp Cys Thr Lys His Arg Cys Val 
    130                 135                 140                 


Asp Glu Ser Glu Gly Arg Leu Trp Ala Glu Ser Lys Gly Phe Leu Tyr 
145                 150                 155                 160 


Phe Glu Thr Ser Ala Gln Thr Gly Glu Gly Ile Asn Glu Met Phe Gln 
                165                 170                 175     


Thr Phe Tyr Ile Ser Ile Val Asp Leu Cys Glu Asn Gly Gly Lys Arg 
            180                 185                 190         


Pro Thr Thr Asn Ser Ser Ala Ser Phe Thr Lys Glu Gln Ala Asp Ala 
        195                 200                 205             


Ile Arg Arg Ile Arg Asn Ser Lys Asp Ser Trp Asp Met Leu Gly Val 
    210                 215                 220                 


Lys Pro Gly Ala Ser Arg Asp Glu Val Asn Lys Ala Tyr Arg Lys Leu 
225                 230                 235                 240 


Ala Val Leu Leu His Pro Asp Lys Cys Val Ala Pro Gly Ser Glu Asp 
                245                 250                 255     


Ala Phe Lys Ala Val Val Asn Ala Arg Thr Ala Leu Leu Lys Asn Ile 
            260                 265                 270         


Lys 
    


<210>  8277
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC27__Homo_sapiens__AAF44347

<400>  8277
auggaggcca acaugccgaa gcggaaggag cccggcaggu cucuccgcau caaagucauc       60

uccaugggca acgccgaagu ggggaaaagc uguauuauaa agcgauacug ugagaaaaga      120

uucgugucua aauaccuggc aacaauugga auugacuaug gagucacaaa gguacacguc      180

agagacagag aaaucaaagu uaacaucuuu gauauggcug gacaucccuu cuucuaugag      240

guucgaaaug aguuuuacaa ggacacacag ggugugauac uggucuauga uguugggcag      300

aaagacuccu uugacgcccu ugaugcgugg cuggcagaaa ugaagcaaga gcuuggaccu      360

cauggaaaca uggaaaauau uauauuugua guuugugcca acaagauuga uuguaccaaa      420

caucgcugug uagaugaaag ugaaggacgu cuuugggcug aaagcaaagg guuccuguac      480

uuugaaacuu cagcacaaac uggagaaggc auuaaugaga uguuccagac cuuuuauaua      540

uccauaguug auuuauguga aaauggcggg aaacgcccua ccaccaauag cagugcuagu      600

uucaccaaag aacaagcaga ugccauucgc agaauucgaa auaguaaaga caguugggac      660

augcugggag ucaaaccugg ggccucaagg gaugaaguca auaaagcgua ucggaaacuu      720

gcugugcuuc uucacccuga caaaugugua gcaccuggca gugaagaugc cuucaaagca      780

guugugaaug cucggacagc ccuccugaaa aacaucaagu ag                         822


<210>  8278
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC27__Homo_sapiens__AAF44347

<400>  8278
auggaggcca acaugcccaa gcgcaaggag ccgggccgga gccugcgcau caaggugauc       60

uccaugggga acgccgaggu cggcaagagc ugcaucauca agcgguacug cgagaagcgc      120

uucgugucca aguaccucgc gaccaucggg aucgacuacg gcgugaccaa gguccacgug      180

cgggaccgcg agaucaaggu gaacaucuuc gacauggccg ggcaccccuu cuucuacgag      240

guccggaacg aguucuacaa ggacacgcag ggcgugaucc ugguguacga cgucggccag      300

aaggacagcu ucgacgcccu ggacgccugg cucgccgaga ugaagcagga gcuggggccc      360

cacggcaaca uggagaacau caucuucgug gugugcgcga acaagaucga cugcaccaag      420

caccgcugcg ucgacgaguc cgaggggcgg cugugggccg agagcaaggg cuuccucuac      480

uucgagaccu ccgcccagac cggggagggc aucaacgaga uguuccagac guucuacauc      540

agcaucgugg accugugcga gaacggcggg aagcgcccca ccaccaacuc cagcgccucc      600

uucaccaagg agcaggcgga cgccauccgg cgcauccgga acagcaagga cuccugggac      660

augcugggcg ugaagccggg ggccagccgc gacgagguca acaaggccua ccggaagcuc      720

gccgugcugc ugcaccccga caagugcgug gcgcccggcu ccgaggacgc cuucaaggcc      780

gucgugaacg cccgcacggc ccuccugaag aacaucaagu ga                         822


<210>  8279
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC27__Homo_sapiens__AAF44347

<400>  8279
auggaggcca acaugcccaa gcgcaaggag cccggccgcu cccuccgcau caaggucauc       60

uccaugggca acgccgaggu cggcaagucc ugcaucauca agcgcuacug cgagaagcgc      120

uucgucucca aguaccucgc caccaucggc aucgacuacg gcgucaccaa gguccacguc      180

cgcgaccgcg agaucaaggu caacaucuuc gacauggccg gccaccccuu cuucuacgag      240

guccgcaacg aguucuacaa ggacacccag ggcgucaucc ucgucuacga cgucggccag      300

aaggacuccu ucgacgcccu cgacgccugg cucgccgaga ugaagcagga gcucggcccc      360

cacggcaaca uggagaacau caucuucguc gucugcgcca acaagaucga cugcaccaag      420

caccgcugcg ucgacgaguc cgagggccgc cucugggccg aguccaaggg cuuccucuac      480

uucgagaccu ccgcccagac cggcgagggc aucaacgaga uguuccagac cuucuacauc      540

uccaucgucg accucugcga gaacggcggc aagcgcccca ccaccaacuc cuccgccucc      600

uucaccaagg agcaggccga cgccauccgc cgcauccgca acuccaagga cuccugggac      660

augcucggcg ucaagcccgg cgccucccgc gacgagguca acaaggccua ccgcaagcuc      720

gccguccucc uccaccccga caagugcguc gcccccggcu ccgaggacgc cuucaaggcc      780

gucgucaacg cccgcaccgc ccuccucaag aacaucaagu ga                         822


<210>  8280
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC27__Homo_sapiens__AAF44347

<400>  8280
auggaggcca acaugcccaa gagaaaagaa ccuggcagga gccugcggau caaggugauu       60

uccaugggga augcugaggu cggaaaaucu ugcauaauca agcgcuacug ugaaaaacga      120

uucguuucaa aguaucucgc aaccauuggu aucgacuacg gcgugacaaa gguacacgug      180

cgugauagag agauuaaagu caacaucuuu gacauggccg ggcauccauu cuuuuaugaa      240

gugaggaaug aguucuacaa ggauacucag ggaguuauac uuguguauga cgucggccaa      300

aaagauaguu uugacgcgcu ggaugcuugg uuggccgaga ugaagcagga auuagguccg      360

cacgggaaca uggagaauau cauuuucgug guaugcgcaa acaaaaucga cuguacgaag      420

caucggugcg uugaugaaag cgagggacgc cugugggccg aguccaaggg cuuucuauac      480

uucgaaaccu cugcucagac aggcgagggg auuaaugaaa uguuucagac uuucuauauc      540

ucgauagugg accucuguga gaacggaggu aaaagaccca ccacaaauuc aagcgcaagu      600

uuuaccaagg aacaagccga ugcuauuagg cggauccgca acuccaaaga cucuugggau      660

augcugggcg ucaagccugg ggccagccga gacgagguga auaaagcgua cagaaaacuu      720

gcagugcugu ugcacccaga caagugcguc gcccccggau ccgaggaugc uuucaaggcc      780

guugugaacg caaggacugc ucuccugaag aauauuaaau ga                         822


<210>  8281
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC27__Homo_sapiens__AAF44347

<400>  8281
auggaggcca acaugcccaa gagaaaggag cccggcagaa gccugagaau caaggugauc       60

agcaugggca acgccgaggu gggcaagagc ugcaucauca agagauacug cgagaagaga      120

uucgugagca aguaccuggc caccaucggc aucgacuacg gcgugaccaa ggugcacgug      180

agagacagag agaucaaggu gaacaucuuc gacauggccg gccaccccuu cuucuacgag      240

gugagaaacg aguucuacaa ggacacccag ggcgugaucc ugguguacga cgugggccag      300

aaggacagcu ucgacgcccu ggacgccugg cuggccgaga ugaagcagga gcugggcccc      360

cacggcaaca uggagaacau caucuucgug gugugcgcca acaagaucga cugcaccaag      420

cacagaugcg uggacgagag cgagggcaga cugugggccg agagcaaggg cuuccuguac      480

uucgagacca gcgcccagac cggcgagggc aucaacgaga uguuccagac cuucuacauc      540

agcaucgugg accugugcga gaacggcggc aagagaccca ccaccaacag cagcgccagc      600

uucaccaagg agcaggccga cgccaucaga agaaucagaa acagcaagga cagcugggac      660

augcugggcg ugaagcccgg cgccagcaga gacgagguga acaaggccua cagaaagcug      720

gccgugcugc ugcaccccga caagugcgug gcccccggca gcgaggacgc cuucaaggcc      780

guggugaacg ccagaaccgc ccugcugaag aacaucaagu ga                         822


<210>  8282
<211>  822
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC27__Homo_sapiens__AAF44347

<400>  8282
auggaggcca acaugcccaa gagaaaagaa ccuggccgga gccugcgcau caaggugauu       60

uccaugggga augcugaggu cggaaaaucu ugcaucauua agagauacug ugaaaaacgg      120

uucguuagca aguaucucgc caccaucggc auugacuacg gggugacaaa ggugcacguc      180

cgcgauagag agaucaaagu gaacaucuuu gacauggcgg gacauccguu cuuuuaugaa      240

guucggaaug aguucuacaa ggauacgcag ggcgugauuc uggucuauga cguggggcaa      300

aaagauuccu uugacgcucu ugaugccugg cuggccgaga ugaagcagga acucggaccc      360

cacggcaaca uggagaauau cauuuucguu gugugcgcua acaaaaucga cuguaccaag      420

caucgcugcg ucgaugaauc ugagggcaga cugugggccg agagcaaggg guuucuuuac      480

uucgaaacau ccgcucagac cggagagggc auuaaugaaa uguuucagac auucuauauc      540

ucuauugugg accuguguga gaacggggga aaacggccua ccacaaauag cuccgccagc      600

uuuaccaagg aacaagcgga ugccauccgc agaauccgga acucuaaaga cuccugggau      660

augcucggcg ugaagcccgg ggcuagccgc gacgagguca auaaagccua cagaaagcug      720

gcuguucugc uccacccuga caaaugcgug gcccccggau cugaggaugc guucaaggcc      780

guggucaacg cucggacggc ccugcuuaag aauauuaaau ga                         822


<210>  8283
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC28__Homo_sapiens__Q9NX36

<400>  8283

Met Asn Thr Met Tyr Val Met Met Ala Gln Ile Leu Arg Ser His Leu 
1               5                   10                  15      


Ile Lys Ala Thr Val Ile Pro Asn Arg Val Lys Met Leu Pro Tyr Phe 
            20                  25                  30          


Gly Ile Ile Arg Asn Arg Met Met Ser Thr His Lys Ser Lys Lys Lys 
        35                  40                  45              


Ile Arg Glu Tyr Tyr Arg Leu Leu Asn Val Glu Glu Gly Cys Ser Ala 
    50                  55                  60                  


Asp Glu Val Arg Glu Ser Phe His Lys Leu Ala Lys Gln Tyr His Pro 
65                  70                  75                  80  


Asp Ser Gly Ser Asn Thr Ala Asp Ser Ala Thr Phe Ile Arg Ile Glu 
                85                  90                  95      


Lys Ala Tyr Arg Lys Val Leu Ser His Val Ile Glu Gln Thr Asn Ala 
            100                 105                 110         


Ser Gln Ser Lys Gly Glu Glu Glu Glu Asp Val Glu Lys Phe Lys Tyr 
        115                 120                 125             


Lys Thr Pro Gln His Arg His Tyr Leu Ser Phe Glu Gly Ile Gly Phe 
    130                 135                 140                 


Gly Thr Pro Thr Gln Arg Glu Lys His Tyr Arg Gln Phe Arg Ala Asp 
145                 150                 155                 160 


Arg Ala Ala Glu Gln Val Met Glu Tyr Gln Lys Gln Lys Leu Gln Ser 
                165                 170                 175     


Gln Tyr Phe Pro Asp Ser Val Ile Val Lys Asn Ile Arg Gln Ser Lys 
            180                 185                 190         


Gln Gln Lys Ile Thr Gln Ala Ile Glu Arg Leu Val Glu Asp Leu Ile 
        195                 200                 205             


Gln Glu Ser Met Ala Lys Gly Asp Phe Asp Asn Leu Ser Gly Lys Gly 
    210                 215                 220                 


Lys Pro Leu Lys Lys Phe Ser Asp Cys Ser Tyr Ile Asp Pro Met Thr 
225                 230                 235                 240 


His Asn Leu Asn Arg Ile Leu Ile Asp Asn Gly Tyr Gln Pro Glu Trp 
                245                 250                 255     


Ile Leu Lys Gln Lys Glu Ile Ser Asp Thr Ile Glu Gln Leu Arg Glu 
            260                 265                 270         


Ala Ile Leu Val Ser Arg Lys Lys Leu Gly Asn Pro Met Thr Pro Thr 
        275                 280                 285             


Glu Lys Lys Gln Trp Asn His Val Cys Glu Gln Phe Gln Glu Asn Ile 
    290                 295                 300                 


Arg Lys Leu Asn Lys Arg Ile Asn Asp Phe Asn Leu Ile Val Pro Ile 
305                 310                 315                 320 


Leu Thr Arg Gln Lys Val His Phe Asp Ala Gln Lys Glu Ile Val Arg 
                325                 330                 335     


Ala Gln Lys Ile Tyr Glu Thr Leu Ile Lys Thr Lys Glu Val Thr Asp 
            340                 345                 350         


Arg Asn Pro Asn Asn Leu Asp Gln Gly Glu Gly Glu Lys Thr Pro Glu 
        355                 360                 365             


Ile Lys Lys Gly Phe Leu Asn Trp Met Asn Leu Trp Lys Phe Ile Lys 
    370                 375                 380                 


Ile Arg Ser Phe 
385             


<210>  8284
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC28__Homo_sapiens__AAL59618

<400>  8284
augaauacaa uguaugugau gauggcucag aucuuaagau cucaccugau aaaggcuaca       60

gugauuccua aucgagugaa aaugcuucca uauuuuggua ucauuagaaa uagaaugaug      120

ucaacccaua aauccaaaaa gaagaucaga gaauauuaua gacugcugaa cguggaggaa      180

ggaugcucug cagaugaagu cagggaaucu uuucauaagc uugccaagca auaucauccu      240

gacaguggcu cuaauacugc ugauucugca acauuuauaa ggauugaaaa agcuuauaga      300

aaggugcucu cccaugugau agaacaaaca aaugccaguc agaguaaagg ugaagaagaa      360

gaagauguag aaaaauucaa auauaaaaca ccccaacacc gacauuauuu aaguuuugaa      420

gguauugguu uugggacucc aacucaacga gagaagcauu auaggcaauu uagggcagac      480

cgugcugcug aacaagugau ggaauaucaa aagcagaaac uacaaagcca guauuuuccu      540

gauaguguaa uuguuaaaaa uauaagacag agcaaacagc aaaagauaac gcaagcuaua      600

gaacguuuag uggaggaccu cauucaagaa uccauggcaa aaggagacuu ugacaaucuc      660

agugggaaag gaaaaccucu gaaaaaguuu ucugacuguu cuuacauuga ucccaugacu      720

cacaaccuga accgaauacu gaucgauaau ggauaccaac cagaauggau ccuuaagcaa      780

aaggaaauaa gcgauacuau ugagcaacuc agagaggcaa uuuuaguguc uaggaaaaaa      840

cuugggaauc caaugacacc aacugaaaag aaacagugga accauguuug ugagcaguuu      900

caagaaaaca ucagaaaauu aaacaagcga auuaaugauu uuaauuuaau uguucccauc      960

cugaccaggc aaaaagucca uuuugaugcu cagaaagaaa uugucagagc ccagaaaaua     1020

uacgagaccc uuauaaaaac aaaagaaguc acagauagaa acccaaauaa ccuugaucaa     1080

ggagaaggag agaaaacacc ugaaaucaag aaagguuuuu uaaacuggau gaaucugugg     1140

aaauuuauua aaauacgauc auuuuga                                         1167


<210>  8285
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC28__Homo_sapiens__AAL59618

<400>  8285
augaacacca uguacgugau gauggcccag auccugcgca gccaccucau caaggccacc       60

gucaucccca accgggugaa gaugcugccg uacuucggca ucauccgcaa ccggaugaug      120

uccacgcaca agagcaagaa gaagauccgc gaguacuacc ggcugcucaa cguggaggag      180

gggugcuccg cggacgaggu ccgcgagagc uuccacaagc uggccaagca guaccacccc      240

gacuccggca gcaacaccgc cgacuccgcc accuucaucc ggaucgagaa ggccuaccgc      300

aaggugcuga gccacgugau cgagcagacc aacgcguccc agagcaaggg ggaggaggag      360

gaggacgucg agaaguucaa guacaagacg ccccagcacc ggcacuaccu cuccuucgag      420

ggcaucgggu ucggcacccc cacccagcgc gagaagcacu accggcaguu ccgcgccgac      480

cgggccgccg agcaggucau ggaguaccag aagcagaagc ugcagagcca guacuucccg      540

gacuccguga ucgugaagaa cauccgccag agcaagcagc agaagaucac ccaggcgauc      600

gagcggcugg uggaggaccu cauccaggag uccauggcca agggcgacuu cgacaaccug      660

agcgggaagg gcaagccccu gaagaaguuc uccgacugca gcuacaucga ccccaugacg      720

cacaaccuca accgcauccu gaucgacaac ggguaccagc ccgaguggau ccugaagcag      780

aaggagaucu ccgacaccau cgagcagcuc cgggaggcca uccuggugag ccgcaagaag      840

cugggcaacc cgaugacccc caccgagaag aagcagugga accacgucug cgagcaguuc      900

caggagaaca uccggaagcu caacaagcgc aucaacgacu ucaaccugau cgugcccauc      960

cugacgcggc agaaggugca cuucgacgcc cagaaggaga ucguccgcgc ccagaagauc     1020

uacgagaccc ucaucaagac caaggaggug accgaccgca accccaacaa ccuggaccag     1080

ggggagggcg agaagacgcc ggagaucaag aagggcuucc ugaacuggau gaaccucugg     1140

aaguucauca agauccggag cuucuga                                         1167


<210>  8286
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC28__Homo_sapiens__AAL59618

<400>  8286
augaacacca uguacgucau gauggcccag auccuccgcu cccaccucau caaggccacc       60

gucaucccca accgcgucaa gaugcucccc uacuucggca ucauccgcaa ccgcaugaug      120

uccacccaca aguccaagaa gaagauccgc gaguacuacc gccuccucaa cgucgaggag      180

ggcugcuccg ccgacgaggu ccgcgagucc uuccacaagc ucgccaagca guaccacccc      240

gacuccggcu ccaacaccgc cgacuccgcc accuucaucc gcaucgagaa ggccuaccgc      300

aagguccucu cccacgucau cgagcagacc aacgccuccc aguccaaggg cgaggaggag      360

gaggacgucg agaaguucaa guacaagacc ccccagcacc gccacuaccu cuccuucgag      420

ggcaucggcu ucggcacccc cacccagcgc gagaagcacu accgccaguu ccgcgccgac      480

cgcgccgccg agcaggucau ggaguaccag aagcagaagc uccaguccca guacuucccc      540

gacuccguca ucgucaagaa cauccgccag uccaagcagc agaagaucac ccaggccauc      600

gagcgccucg ucgaggaccu cauccaggag uccauggcca agggcgacuu cgacaaccuc      660

uccggcaagg gcaagccccu caagaaguuc uccgacugcu ccuacaucga ccccaugacc      720

cacaaccuca accgcauccu caucgacaac ggcuaccagc ccgaguggau ccucaagcag      780

aaggagaucu ccgacaccau cgagcagcuc cgcgaggcca uccucgucuc ccgcaagaag      840

cucggcaacc ccaugacccc caccgagaag aagcagugga accacgucug cgagcaguuc      900

caggagaaca uccgcaagcu caacaagcgc aucaacgacu ucaaccucau cguccccauc      960

cucacccgcc agaaggucca cuucgacgcc cagaaggaga ucguccgcgc ccagaagauc     1020

uacgagaccc ucaucaagac caaggagguc accgaccgca accccaacaa ccucgaccag     1080

ggcgagggcg agaagacccc cgagaucaag aagggcuucc ucaacuggau gaaccucugg     1140

aaguucauca agauccgcuc cuucuga                                         1167


<210>  8287
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC28__Homo_sapiens__AAL59618

<400>  8287
augaacacca uguacgugau gauggcccag auccugagaa gccaccucau uaaggcuaca       60

gucauaccca auaggguuaa aaugcuuccu uauuucggca ucauucggaa ccgcaugaug      120

uccacucaua agucuaaaaa gaaaauccga gaguacuauc gucuguugaa uguggaagag      180

gggugcucag cagacgaagu aagagagagu uuucacaagu uagccaagca auaccaucca      240

gauagcggau ccaacacggc ggacucugcu accuucauua ggaucgaaaa agccuaucgg      300

aaggugcugu cgcacgucau agagcagaca aaugcaucac agagcaaagg ugaggaagag      360

gaagaugugg agaaguuuaa auacaagacu ccgcagcauc gccacuaucu aaguuucgag      420

ggcaucgggu uuggaacccc cacacaaaga gaaaagcacu acaggcaguu ccgggccgac      480

cgcgcugcag agcagguuau ggaauaccag aaacaaaagc uccaguccca guauuuuccu      540

gauucuguga uugucaaaaa cauccgacag agcaagcaac agaaaauuac ccaggccauc      600

gagagacugg uggaagaccu uauacaagag uccauggcua agggcgauuu cgacaaucug      660

ucagguaaag ggaagccauu gaagaaauuu agugauugua gcuacauuga ccccaugacu      720

cauaaccuca auaggauccu gauugauaac ggauaucagc cugaguggau ccugaagcag      780

aaagaaaucu cugacacaau ugagcagcuc cgggaagcca uauuaguauc ccguaagaaa      840

cugggcaauc caaugacccc cacggagaag aagcaaugga accacguuug cgaacaguuc      900

caggagaaua uccgcaaacu uaacaagaga auuaaugauu uuaacuugau cgugccuaua      960

cugacuaggc agaaagucca uuucgacgcg caaaaggaga uugugcgggc acagaaaauc     1020

uacgaaaccc uaaucaagac aaaggaggug acugaccgaa acccaaauaa ccucgaucag     1080

ggcgaagggg agaaaacccc ggaaauuaag aaaggauuuc ugaauuggau gaaccuuugg     1140

aaguucauca aaauucgcuc auucuga                                         1167


<210>  8288
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC28__Homo_sapiens__AAL59618

<400>  8288
augaacacca uguacgugau gauggcccag auccugagaa gccaccugau caaggccacc       60

gugaucccca acagagugaa gaugcugccc uacuucggca ucaucagaaa cagaaugaug      120

agcacccaca agagcaagaa gaagaucaga gaguacuaca gacugcugaa cguggaggag      180

ggcugcagcg ccgacgaggu gagagagagc uuccacaagc uggccaagca guaccacccc      240

gacagcggca gcaacaccgc cgacagcgcc accuucauca gaaucgagaa ggccuacaga      300

aaggugcuga gccacgugau cgagcagacc aacgccagcc agagcaaggg cgaggaggag      360

gaggacgugg agaaguucaa guacaagacc ccccagcaca gacacuaccu gagcuucgag      420

ggcaucggcu ucggcacccc cacccagaga gagaagcacu acagacaguu cagagccgac      480

agagccgccg agcaggugau ggaguaccag aagcagaagc ugcagagcca guacuucccc      540

gacagcguga ucgugaagaa caucagacag agcaagcagc agaagaucac ccaggccauc      600

gagagacugg uggaggaccu gauccaggag agcauggcca agggcgacuu cgacaaccug      660

agcggcaagg gcaagccccu gaagaaguuc agcgacugca gcuacaucga ccccaugacc      720

cacaaccuga acagaauccu gaucgacaac ggcuaccagc ccgaguggau ccugaagcag      780

aaggagauca gcgacaccau cgagcagcug agagaggcca uccuggugag cagaaagaag      840

cugggcaacc ccaugacccc caccgagaag aagcagugga accacgugug cgagcaguuc      900

caggagaaca ucagaaagcu gaacaagaga aucaacgacu ucaaccugau cgugcccauc      960

cugaccagac agaaggugca cuucgacgcc cagaaggaga ucgugagagc ccagaagauc     1020

uacgagaccc ugaucaagac caaggaggug accgacagaa accccaacaa ccuggaccag     1080

ggcgagggcg agaagacccc cgagaucaag aagggcuucc ugaacuggau gaaccugugg     1140

aaguucauca agaucagaag cuucuga                                         1167


<210>  8289
<211>  1167
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC28__Homo_sapiens__AAL59618

<400>  8289
augaacacca uguacgugau gauggcccag auccugagaa gccaccucau uaaggcuaca       60

gucaucccca aucggguuaa aaugcugccu uauuucggca uuauccgcaa cagaaugaug      120

uccacgcaua agucuaaaaa gaaaauucgg gaguacuauc gccuucugaa uguggaagag      180

gggugcagcg ccgacgaagu gagagagucc uuucacaagc ucgcgaagca auaccauccg      240

gauucuggaa gcaacaccgc ugacuccgcc acauucaucc ggaucgaaaa agccuaucgc      300

aagguccugu cucacgugau ugagcagacc aaugcuagcc aguccaaagg cgaggaagag      360

gaagauguug agaaguuuaa auacaagaca ccccagcaua gacacuaucu uagcuucgag      420

gggaucggau uuggcacccc uacacaacgg gaaaagcacu accgccaguu cagagccgac      480

cgggcugccg aacaggugau ggaguaccag aaacaaaagc ugcagucuca guauuuuccc      540

gauuccguca uugugaaaaa cauccgccag agcaagcaac agaaaauuac ccaggcgauc      600

gagagacucg uugaagaccu gauucaagag ucuauggcca agggggauuu cgacaaucug      660

uccggaaaag gcaagccucu caagaaauuu agcgauuguu cuuacaucga ccccaugacg      720

cauaaccuga aucggauccu uauugauaac ggcuaucagc cugaguggau ccugaagcag      780

aaagaaauuu ccgacaccau cgagcagcuc cgcgaagcua uucuggugag cagaaagaaa      840

cuugggaauc cgaugacacc caccgagaag aagcaaugga accacgucug cgaacaguuc      900

caggagaaua uccggaaacu gaacaagaga aucaaugauu uuaaccucau ugugccuauc      960

cugacacgcc agaaagugca uuucgacgcc caaaaggaga uuguccgggc ucagaaaauc     1020

uacgaaaccc ugauuaagac gaaggagguu acagacagaa accccaauaa ccucgaucag     1080

ggagaaggcg agaaaacccc ugaaaucaag aaaggguuuc ugaauuggau gaaccuuugg     1140

aaguucauca aaauucgcuc cuucuga                                         1167


<210>  8290
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DJC30__Homo_sapiens__Q96LL9

<400>  8290

Met Ala Ala Met Arg Trp Arg Trp Trp Gln Arg Leu Leu Pro Trp Arg 
1               5                   10                  15      


Leu Leu Gln Ala Arg Gly Phe Pro Gln Asn Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Leu Gly Ala Arg Thr Tyr Ser Gln Gly Asp Cys Ser Tyr Ser Arg Thr 
        35                  40                  45              


Ala Leu Tyr Asp Leu Leu Gly Val Pro Ser Thr Ala Thr Gln Ala Gln 
    50                  55                  60                  


Ile Lys Ala Ala Tyr Tyr Arg Gln Cys Phe Leu Tyr His Pro Asp Arg 
65                  70                  75                  80  


Asn Ser Gly Ser Ala Glu Ala Ala Glu Arg Phe Thr Arg Ile Ser Gln 
                85                  90                  95      


Ala Tyr Val Val Leu Gly Ser Ala Thr Leu Arg Arg Lys Tyr Asp Arg 
            100                 105                 110         


Gly Leu Leu Ser Asp Glu Asp Leu Arg Gly Pro Gly Val Arg Pro Ser 
        115                 120                 125             


Arg Thr Pro Ala Pro Asp Pro Gly Ser Pro Arg Thr Pro Pro Pro Thr 
    130                 135                 140                 


Ser Arg Thr His Asp Gly Ser Arg Ala Ser Pro Gly Ala Asn Arg Thr 
145                 150                 155                 160 


Met Phe Asn Phe Asp Ala Phe Tyr Gln Ala His Tyr Gly Glu Gln Leu 
                165                 170                 175     


Glu Arg Glu Arg Arg Leu Arg Ala Arg Arg Glu Ala Leu Arg Lys Arg 
            180                 185                 190         


Gln Glu Tyr Arg Ser Met Lys Gly Leu Arg Trp Glu Asp Thr Arg Asp 
        195                 200                 205             


Thr Ala Ala Ile Phe Leu Ile Phe Ser Ile Phe Ile Ile Ile Gly Phe 
    210                 215                 220                 


Tyr Ile 
225     


<210>  8291
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DJC30__Homo_sapiens__AAM62307

<400>  8291
auggcagcca ugcgcuggcg augguggcag cggcuguuac cuuggagguu gcugcaggcc       60

cguggcuuuc cacaaaauuc ugcacccagc cugggccuag gagcgaggac uuauucccag      120

ggcgacugcu cguauucgcg cacggcgcug uaugaucugc ucggcguccc cuccacagcc      180

acgcaggccc aaaucaaggc ggcuuacuac cgucagugcu uucucuacca cccggaccgc      240

aacuccggga gcgcggaggc cgccgagcgc uucacgcgca ucucccaggc cuacguggug      300

cugggcagug ccacccuccg ucgcaaguau gaucgcggcc uacucagcga cgaggaccug      360

cgcggaccug gcguccggcc cuccaggacg cccgcacccg accccggcuc gccgcguacc      420

ccgccgccca ccucucggac ccacgacggu ucucgggccu cccccggcgc caaccgcacg      480

auguucaacu uugacgccuu cuaccaggcc cacuacgggg aacaacugga gcgggaacgg      540

cgccugaggg cccggcggga ggcccuucgc aaacggcagg aguaucgguc caugaaaggc      600

cuccgcuggg aggauacccg agacacggcu gccauuuucc ucaucuuuuc aaucuucauc      660

aucaucggcu uuuauauuua a                                                681


<210>  8292
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DJC30__Homo_sapiens__AAM62307

<400>  8292
auggccgcca ugcgcuggcg gugguggcag cgccugcucc ccuggcggcu gcugcaggcg       60

cgcggcuucc cccagaacag cgcccccucc cucgggcugg gcgcccggac cuacagccag      120

ggggacugcu ccuacagccg caccgcccug uacgaccucc ugggcgugcc cuccacggcc      180

acccaggcgc agaucaaggc cgccuacuac cggcagugcu uccuguacca ccccgaccgc      240

aacagcgggu ccgccgaggc ggccgagcgg uucacccgca ucagccaggc cuacgucgug      300

cucggcuccg ccacccugcg gcgcaaguac gaccggggcc ugcucagcga cgaggaccug      360

cgcgggccgg gcgugcggcc cucccgcacg cccgcccccg acccggggag cccccggacc      420

ccgccgccca ccucccgcac ccacgacggc agccgggcgu cccccggggc caaccgcacg      480

auguucaacu ucgacgccuu cuaccaggcc cacuacggcg agcagcugga gcgggagcgc      540

cgccuccggg cccgccggga ggcgcugcgc aagcggcagg aguaccgcag caugaagggc      600

cugcgguggg aggacacccg cgacaccgcc gccaucuucc ucaucuucuc caucuucauc      660

aucaucgggu ucuacaucug a                                                681


<210>  8293
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DJC30__Homo_sapiens__AAM62307

<400>  8293
auggccgcca ugcgcuggcg cugguggcag cgccuccucc ccuggcgccu ccuccaggcc       60

cgcggcuucc cccagaacuc cgcccccucc cucggccucg gcgcccgcac cuacucccag      120

ggcgacugcu ccuacucccg caccgcccuc uacgaccucc ucggcguccc cuccaccgcc      180

acccaggccc agaucaaggc cgccuacuac cgccagugcu uccucuacca ccccgaccgc      240

aacuccggcu ccgccgaggc cgccgagcgc uucacccgca ucucccaggc cuacgucguc      300

cucggcuccg ccacccuccg ccgcaaguac gaccgcggcc uccucuccga cgaggaccuc      360

cgcggccccg gcguccgccc cucccgcacc cccgcccccg accccggcuc cccccgcacc      420

ccccccccca ccucccgcac ccacgacggc ucccgcgccu cccccggcgc caaccgcacc      480

auguucaacu ucgacgccuu cuaccaggcc cacuacggcg agcagcucga gcgcgagcgc      540

cgccuccgcg cccgccgcga ggcccuccgc aagcgccagg aguaccgcuc caugaagggc      600

cuccgcuggg aggacacccg cgacaccgcc gccaucuucc ucaucuucuc caucuucauc      660

aucaucggcu ucuacaucug a                                                681


<210>  8294
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DJC30__Homo_sapiens__AAM62307

<400>  8294
auggccgcua ugagauggag gugguggcag cggcugcucc ccuggcgccu ucugcaagca       60

cgaggcuucc cucagaacag cgccccaucc uugggguuag gagcgcguac cuacucucag      120

ggugacugcu cauauaguag aacagcucug uacgaucuac ucggcgugcc gagcacugcc      180

acgcaggcac aaaucaaggc cgcuuauuac aggcaguguu uucuguauca ccccgaccgc      240

aauuccgggu cugcagaggc cgcugaacgg uucaccagaa uuucgcaggc cuacgucguu      300

cuuggaucag cgacacugag gcggaaauau gaucgcggcu ugcucagcga cgaggaucug      360

cgagguccug gggugagacc aaguaggacu cccgcaccug acccaggauc uccccggacc      420

ccuccaccga caucccguac ccaugauggc agccgcgccu cccccggcgc uaacagaacu      480

auguuuaauu ucgacgccuu uuaccaggca cacuacgggg aacaacugga gagggaacgg      540

cgacuccgcg cuagaaggga ggccuuacgg aagcgccagg aguauagauc aaugaaagga      600

cugagguggg aagauacacg ugacaccgcg gccauauucc uuaucuuuag uauuuucauc      660

auuaucgguu uuuacauaug a                                                681


<210>  8295
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DJC30__Homo_sapiens__AAM62307

<400>  8295
auggccgcca ugagauggag augguggcag agacugcugc ccuggagacu gcugcaggcc       60

agaggcuucc cccagaacag cgcccccagc cugggccugg gcgccagaac cuacagccag      120

ggcgacugca gcuacagcag aaccgcccug uacgaccugc ugggcgugcc cagcaccgcc      180

acccaggccc agaucaaggc cgccuacuac agacagugcu uccuguacca ccccgacaga      240

aacagcggca gcgccgaggc cgccgagaga uucaccagaa ucagccaggc cuacguggug      300

cugggcagcg ccacccugag aagaaaguac gacagaggcc ugcugagcga cgaggaccug      360

agaggccccg gcgugagacc cagcagaacc cccgcccccg accccggcag ccccagaacc      420

ccccccccca ccagcagaac ccacgacggc agcagagcca gccccggcgc caacagaacc      480

auguucaacu ucgacgccuu cuaccaggcc cacuacggcg agcagcugga gagagagaga      540

agacugagag ccagaagaga ggcccugaga aagagacagg aguacagaag caugaagggc      600

cugagauggg aggacaccag agacaccgcc gccaucuucc ugaucuucag caucuucauc      660

aucaucggcu ucuacaucug a                                                681


<210>  8296
<211>  681
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DJC30__Homo_sapiens__AAM62307

<400>  8296
auggccgcua ugagauggcg gugguggcag cgccugcucc ccuggagacu gcuucaagcc       60

cggggcuucc cucagaacag cgcgccgucc cuggggcucg gagcucgcac cuacucucag      120

ggcgacugca gcuauuccag aacagcccug uacgaucuuc ugggggugcc cucuacggcc      180

acccaggcuc aaaucaaggc cgcuuauuac cggcaguguu uucucuauca cccugaccgc      240

aauagcggau ccgccgaggc ggccgaaaga uucacacgga uuucucaggc uuacgucguu      300

cugggcagcg ccacccugcg cagaaaauau gaucgggggc uccuguccga cgaggaucuu      360

cgcggacccg gcgugagacc uagccggaca cccgcuccug acccgggcuc uccccgcacc      420

ccucccccua cauccagaac ccaugauggg agccgggccu cucccggagc gaacagaacg      480

auguuuaauu ucgacgccuu uuaccaggcu cacuacggcg aacaacugga gcgcgaacgg      540

agacuccgcg cccggagaga ggcucugcgc aagcggcagg aguauagauc caugaaaggg      600

cuucgcuggg aagauacccg ggacacagcc gccaucuucc ugauuuuuag caucuucauu      660

aucaucggau uuuacauuug a                                                681


<210>  8297
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNAJB12__Homo_sapiens__NP_001002762.2

<400>  8297

Met Ser Ser Leu Arg Ala Arg Leu Pro Ala Thr Arg Arg Arg Val Ala 
1               5                   10                  15      


Gln Pro Phe Ala Arg Pro Ala Ser Pro Ser Leu Val Pro Arg Ser Gly 
            20                  25                  30          


Ser Ala Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile 
        35                  40                  45              


Ala Leu Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe 
    50                  55                  60                  


Leu Glu Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu 
65                  70                  75                  80  


Ile Glu Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro 
                85                  90                  95      


Pro Thr Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp 
            100                 105                 110         


Ala Pro Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr 
        115                 120                 125             


Thr Ala Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp 
    130                 135                 140                 


Tyr Tyr Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu 
145                 150                 155                 160 


Lys Lys Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn 
                165                 170                 175     


His Ala Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr 
            180                 185                 190         


Ala Val Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly 
        195                 200                 205             


Asp Asp Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe 
    210                 215                 220                 


His Arg Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met 
225                 230                 235                 240 


Phe Phe Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn 
                245                 250                 255     


Gly Arg Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn 
            260                 265                 270         


Gln Gly Asp Gly Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu 
        275                 280                 285             


Ile Leu Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro 
    290                 295                 300                 


Pro Tyr Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg 
305                 310                 315                 320 


Val Thr Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser 
                325                 330                 335     


Glu Glu Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu 
            340                 345                 350         


Asp Asp Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln 
        355                 360                 365             


Gln Lys Glu Gly Leu Leu Tyr Arg Ala Arg Tyr Phe Gly Asp Thr Asp 
    370                 375                 380                 


Met Tyr His Arg Ala Gln Lys Met Gly Thr Pro Ser Cys Ser Arg Leu 
385                 390                 395                 400 


Ser Glu Val Gln Ala Ser Leu His Gly 
                405                 


<210>  8298
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8298
augucaucac uccgcgcccg gcugcccgcg acgcgccggc ggguggcgca gcccuucgcu       60

cgcccggccu cccccucccu gguuccgcgu ucugguuccg ccauggaauc caacaaggau      120

gaagcugagc gcuguaucag caucgcccuc aaggccaucc agagcaacca gcccgaccgg      180

gcgcuccgcu uccuggagaa ggcacagcgg cuguauccga cgccgcgagu ucgcgcccug      240

auugaguccc ucaaccagaa accacagacu gccggugacc aacccccacc cacagacaca      300

acccaugcca cccacaggaa agcagguggg accgaugccc ccucggccaa cggugaagcu      360

ggaggagaga gcaccaaagg cuacacugca gaacagguug cagcugugaa aagggucaag      420

caauguaaag auuacuauga gauccugggg gugagcagag gggccucgga ugaggaccug      480

aagaaggccu accgcagacu ggcccucaaa uuccacccag acaagaacca cgcaccuggu      540

gccacugaag ccuucaaagc cauuggcaca gcauaugcgg uacucagcaa cccggagaag      600

aggaagcagu augaccaguu cggcgaugac aagagccagg cggcccggca cggccauggg      660

cauggggauu uccaccgugg cuuugaggcc gacaucuccc cugaagaccu cuucaacaug      720

uucuuuggcg gcggcuuccc uucuaguaac guccacgucu acagcaacgg ccgcaugcgc      780

uauaccuacc agcaaaggca ggaccgcagg gacaaccagg gugauggcgg gcuaggggug      840

uuugugcagc ugaugccuau ccucauccug auucucgugu cagcucucag ccagcucaug      900

gucuccaguc cacccuacag ucugagucca agaccguccg ugggccacau ccacaggcga      960

gucacugacc accugggugu cgucuacuau gugggagaca cuuucuccga agaguacaca     1020

ggcuccagcc ucaaaacagu cgagcggaau guggaagaug auuauaucgc caaccuccgg     1080

aacaacugcu ggaaggagaa gcagcagaag gaaggcuugc uguaccgggc acgcuacuuu     1140

ggcgacacag auauguacca cagagcacag aagaugggca cccccagcug cagccgacug     1200

ucagaggugc aggccucccu gcauggauag                                      1230


<210>  8299
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8299
augagcuccc ugcgcgcccg gcuccccgcc acccgccggc gcguggcgca gccguucgcc       60

cggcccgcca gccccucccu ggucccccgc agcggcuccg ccauggagag caacaaggac      120

gaggccgagc ggugcaucuc caucgcgcug aaggccaucc agagcaacca gccggaccgc      180

gcccuccggu uccuggagaa ggcccagcgc cuguacccca cgccccgggu gcgcgcgcuc      240

aucgaguccc ugaaccagaa gccccagacc gccggggacc agccgccgcc caccgacacc      300

acccacgcca cgcaccggaa ggccggcggg accgacgccc ccagcgcgaa cggcgaggcc      360

gggggcgagu ccaccaaggg cuacaccgcc gagcaggucg ccgccgugaa gcgcgugaag      420

cagugcaagg acuacuacga gauccugggg gugagccggg gcgcguccga cgaggaccuc      480

aagaaggccu accgccggcu ggcccugaag uuccaccccg acaagaacca cgcccccggg      540

gccacggagg cguucaaggc caucggcacc gccuacgccg uccucagcaa ccccgagaag      600

cgcaagcagu acgaccaguu cggggacgac aagucccagg ccgcgcggca cggccacggc      660

cacggggacu uccaccgcgg cuucgaggcc gacaucagcc ccgaggaccu guucaacaug      720

uucuucgggg gcggcuuccc guccagcaac gugcacgugu acuccaacgg gcggaugcgc      780

uacaccuacc agcagcgcca ggaccggcgc gacaaccagg gcgacggggg ccuggggguc      840

uucgugcagc ucaugcccau ccugauccug auccucguga gcgcccugag ccagcugaug      900

gucuccagcc cgcccuacuc ccucagcccc cggcccuccg ugggccacau ccaccgccgg      960

gugaccgacc accugggcgu cguguacuac gugggggaca cguucagcga ggaguacacc     1020

ggcuccagcc ugaagaccgu cgagcgcaac guggaggacg acuacaucgc caaccuccgg     1080

aacaacugcu ggaaggagaa gcagcagaag gaggggcugc uguaccgcgc gcgguacuuc     1140

ggcgacaccg acauguacca ccgcgcccag aagaugggga cgcccuccug cagccggcuc     1200

uccgaggugc aggccagccu gcacggcuga                                      1230


<210>  8300
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8300
auguccuccc uccgcgcccg ccuccccgcc acccgccgcc gcgucgccca gcccuucgcc       60

cgccccgccu cccccucccu cgucccccgc uccggcuccg ccauggaguc caacaaggac      120

gaggccgagc gcugcaucuc caucgcccuc aaggccaucc aguccaacca gcccgaccgc      180

gcccuccgcu uccucgagaa ggcccagcgc cucuacccca ccccccgcgu ccgcgcccuc      240

aucgaguccc ucaaccagaa gccccagacc gccggcgacc agcccccccc caccgacacc      300

acccacgcca cccaccgcaa ggccggcggc accgacgccc ccuccgccaa cggcgaggcc      360

ggcggcgagu ccaccaaggg cuacaccgcc gagcaggucg ccgccgucaa gcgcgucaag      420

cagugcaagg acuacuacga gauccucggc gucucccgcg gcgccuccga cgaggaccuc      480

aagaaggccu accgccgccu cgcccucaag uuccaccccg acaagaacca cgcccccggc      540

gccaccgagg ccuucaaggc caucggcacc gccuacgccg uccucuccaa ccccgagaag      600

cgcaagcagu acgaccaguu cggcgacgac aagucccagg ccgcccgcca cggccacggc      660

cacggcgacu uccaccgcgg cuucgaggcc gacaucuccc ccgaggaccu cuucaacaug      720

uucuucggcg gcggcuuccc cuccuccaac guccacgucu acuccaacgg ccgcaugcgc      780

uacaccuacc agcagcgcca ggaccgccgc gacaaccagg gcgacggcgg ccucggcguc      840

uucguccagc ucaugcccau ccucauccuc auccucgucu ccgcccucuc ccagcucaug      900

gucuccuccc cccccuacuc ccucuccccc cgccccuccg ucggccacau ccaccgccgc      960

gucaccgacc accucggcgu cgucuacuac gucggcgaca ccuucuccga ggaguacacc     1020

ggcuccuccc ucaagaccgu cgagcgcaac gucgaggacg acuacaucgc caaccuccgc     1080

aacaacugcu ggaaggagaa gcagcagaag gagggccucc ucuaccgcgc ccgcuacuuc     1140

ggcgacaccg acauguacca ccgcgcccag aagaugggca cccccuccug cucccgccuc     1200

uccgaggucc aggccucccu ccacggcuga                                      1230


<210>  8301
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8301
augagcuccc ugagagccag gcuccccgcu acccggcgcc gaguggcaca gccuuucgcc       60

cguccagcgu cuccgucacu uguccccaga aguggcagcg cuauggaguc caacaaggac      120

gaagccgaga ggugcaucuc uauugcacug aaagccauac aaucgaauca gccugaucgg      180

gcuuugcgcu uuuuagaaaa ggcacagaga cuguacccaa cacccagggu ucgggcccua      240

aucgagucac ucaaccagaa accucaaacu gcuggggacc agccaccccc uacggauacc      300

acacacgcca cucaucgcaa ggcgggaggu accgacgcac caagcgccaa uggcgaagcu      360

gggggagaga guacaaaagg cuauaccgcc gagcaagugg cagcuguaaa gcgagugaag      420

caguguaaag auuacuauga aauucugggu gucuccagag gggccucuga cgaggaucuu      480

aagaaagcgu acaggcggcu ggccuugaag uuccacccgg acaaaaacca ugcacccgga      540

gcuacugaag ccuuuaaggc uaucggcaca gccuaugcag ugcucagcaa uccugagaag      600

cguaaacaau acgaucaguu cggcgacgau aagucccagg ccgcucgcca cgggcaugga      660

cacggugacu uucacagagg cuucgaggcg gauauuucac cagaagaccu guuuaacaug      720

uucuuugggg gaggcuuccc caguagcaau guucaugugu auucuaacgg uaggaugcgg      780

uacaccuacc agcaacgaca ggaccgcaga gauaaucagg gggacggagg ccugggcguc      840

uuugugcaac ucaugccuau cuuaauacug auccuuguau ccgcauuguc acagcugaug      900

guuagcaguc cacccuauuc ucuauccccg aggccuagcg uggggcacau ucaucggcgc      960

gucacggauc accucggagu gguguacuau gucggugaca cuuucucgga ggaauacacc     1020

gggucuuccc ugaaaacagu ugagagaaac guggaagaug acuauaucgc caaucuuagg     1080

aacaauugcu ggaaggagaa acagcagaag gagggccugu uguaccgugc ucgguauuuu     1140

ggagauacug acauguacca ccgagcccag aaaaugggca cccccucaug uaguagacuc     1200

agcgaaguac aggcaucccu gcaugguuga                                      1230


<210>  8302
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8302
augagcagcc ugagagccag acugcccgcc accagaagaa gaguggccca gcccuucgcc       60

agacccgcca gccccagccu ggugcccaga agcggcagcg ccauggagag caacaaggac      120

gaggccgaga gaugcaucag caucgcccug aaggccaucc agagcaacca gcccgacaga      180

gcccugagau uccuggagaa ggcccagaga cuguacccca cccccagagu gagagcccug      240

aucgagagcc ugaaccagaa gccccagacc gccggcgacc agcccccccc caccgacacc      300

acccacgcca cccacagaaa ggccggcggc accgacgccc ccagcgccaa cggcgaggcc      360

ggcggcgaga gcaccaaggg cuacaccgcc gagcaggugg ccgccgugaa gagagugaag      420

cagugcaagg acuacuacga gauccugggc gugagcagag gcgccagcga cgaggaccug      480

aagaaggccu acagaagacu ggcccugaag uuccaccccg acaagaacca cgcccccggc      540

gccaccgagg ccuucaaggc caucggcacc gccuacgccg ugcugagcaa ccccgagaag      600

agaaagcagu acgaccaguu cggcgacgac aagagccagg ccgccagaca cggccacggc      660

cacggcgacu uccacagagg cuucgaggcc gacaucagcc ccgaggaccu guucaacaug      720

uucuucggcg gcggcuuccc cagcagcaac gugcacgugu acagcaacgg cagaaugaga      780

uacaccuacc agcagagaca ggacagaaga gacaaccagg gcgacggcgg ccugggcgug      840

uucgugcagc ugaugcccau ccugauccug auccugguga gcgcccugag ccagcugaug      900

gugagcagcc cccccuacag ccugagcccc agacccagcg ugggccacau ccacagaaga      960

gugaccgacc accugggcgu gguguacuac gugggcgaca ccuucagcga ggaguacacc     1020

ggcagcagcc ugaagaccgu ggagagaaac guggaggacg acuacaucgc caaccugaga     1080

aacaacugcu ggaaggagaa gcagcagaag gagggccugc uguacagagc cagauacuuc     1140

ggcgacaccg acauguacca cagagcccag aagaugggca cccccagcug cagcagacug     1200

agcgaggugc aggccagccu gcacggcuga                                      1230


<210>  8303
<211>  1230
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNAJB12__Homo_sapiens__NM_001002762.2

<400>  8303
augagcuccc ugagagcccg gcuccccgcu acccgcagac ggguggccca gccuuucgcg       60

cgcccggcuu cucccagccu ggucccuaga uccggcucug ccauggagag caacaaggac      120

gaagccgagc ggugcaucuc cauugcucuu aaagccaucc aaucuaauca gcccgaucgc      180

gcucugagau uucucgaaaa ggcccagcgg cuguacccua caccccgcgu uagagcgcuu      240

auugagagcc ugaaccagaa accucaaacg gccggggacc agccgccccc uaccgauaca      300

acccacgcua cacaucggaa ggccggaggc accgacgcuc ccuccgccaa uggggaagcg      360

ggaggcgaga gcacaaaagg guauaccgcc gagcaagugg cugccgugaa gcgcgucaag      420

caguguaaag auuacuauga aauccucgga gugucuagag gcgcuuccga cgaggaucug      480

aagaaagccu accggcgccu ggcccucaag uuccacccug acaaaaacca ugcucccggc      540

gcgacggaag ccuuuaaggc uauugggacc gccuaugccg uucugagcaa uccggagaag      600

agaaaacaau acgaucaguu cggagacgau aagucucagg cugcccggca cggccauggg      660

cacggagacu uucacagagg cuucgaggcg gauaucuccc cugaagaccu uuuuaacaug      720

uucuuugggg gaggcuuccc cagcucuaau gugcaugucu auuccaacgg ccgcaugcgg      780

uacacauacc agcaaagaca ggaccgccgg gauaaucagg gggacggagg ccugggggug      840

uuuguucaac ucaugccuau ccugauucuu auccugguga gcgcucucuc ccagcugaug      900

gucucuagcc cucccuauuc ccugagcccc agaccgucug ugggacacau ucaucgccgg      960

gugaccgauc accucggcgu cguuuacuau gugggggaca cauucuccga ggaauacacc     1020

ggaagcucuc ugaaaacggu ggagagaaac gucgaagaug acuauaucgc caaucuucgc     1080

aacaauugcu ggaaggagaa acagcagaag gagggccugc ucuaccgggc cagauauuuu     1140

ggcgauacag acauguacca ccgcgcucag aaaaugggga cccccagcug uucccggcug     1200

ucugaagugc aggccagccu ucauggauga                                      1230


<210>  8304
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNAJC11__Homo_sapiens__Q9NVH1

<400>  8304

Met Ala Thr Ala Leu Ser Glu Glu Glu Leu Asp Asn Glu Asp Tyr Tyr 
1               5                   10                  15      


Ser Leu Leu Asn Val Arg Arg Glu Ala Ser Ser Glu Glu Leu Lys Ala 
            20                  25                  30          


Ala Tyr Arg Arg Leu Cys Met Leu Tyr His Pro Asp Lys His Arg Asp 
        35                  40                  45              


Pro Glu Leu Lys Ser Gln Ala Glu Arg Leu Phe Asn Leu Val His Gln 
    50                  55                  60                  


Ala Tyr Glu Val Leu Ser Asp Pro Gln Thr Arg Ala Ile Tyr Asp Ile 
65                  70                  75                  80  


Tyr Gly Lys Arg Gly Leu Glu Met Glu Gly Trp Glu Val Val Glu Arg 
                85                  90                  95      


Arg Arg Thr Pro Ala Glu Ile Arg Glu Glu Phe Glu Arg Leu Gln Arg 
            100                 105                 110         


Glu Arg Glu Glu Arg Arg Leu Gln Gln Arg Thr Asn Pro Lys Gly Thr 
        115                 120                 125             


Ile Ser Val Gly Val Asp Ala Thr Asp Leu Phe Asp Arg Tyr Asp Glu 
    130                 135                 140                 


Glu Tyr Glu Asp Val Ser Gly Ser Ser Phe Pro Gln Ile Glu Ile Asn 
145                 150                 155                 160 


Lys Met His Ile Ser Gln Ser Ile Glu Ala Pro Leu Thr Ala Thr Asp 
                165                 170                 175     


Thr Ala Ile Leu Ser Gly Ser Leu Ser Thr Gln Asn Gly Asn Gly Gly 
            180                 185                 190         


Gly Ser Ile Asn Phe Ala Leu Arg Arg Val Thr Ser Ala Lys Gly Trp 
        195                 200                 205             


Gly Glu Leu Glu Phe Gly Ala Gly Asp Leu Gln Gly Pro Leu Phe Gly 
    210                 215                 220                 


Leu Lys Leu Phe Arg Asn Leu Thr Pro Arg Cys Phe Val Thr Thr Asn 
225                 230                 235                 240 


Cys Ala Leu Gln Phe Ser Ser Arg Gly Ile Arg Pro Gly Leu Thr Thr 
                245                 250                 255     


Val Leu Ala Arg Asn Leu Asp Lys Asn Thr Val Gly Tyr Leu Gln Trp 
            260                 265                 270         


Arg Trp Gly Ile Gln Ser Ala Met Asn Thr Ser Ile Val Arg Asp Thr 
        275                 280                 285             


Lys Thr Ser His Phe Thr Val Ala Leu Gln Leu Gly Ile Pro His Ser 
    290                 295                 300                 


Phe Ala Leu Ile Ser Tyr Gln His Lys Phe Gln Asp Asp Asp Gln Thr 
305                 310                 315                 320 


Arg Val Lys Gly Ser Leu Lys Ala Gly Phe Phe Gly Thr Val Val Glu 
                325                 330                 335     


Tyr Gly Ala Glu Arg Lys Ile Ser Arg His Ser Val Leu Gly Ala Ala 
            340                 345                 350         


Val Ser Val Gly Val Pro Gln Gly Val Ser Leu Lys Val Lys Leu Asn 
        355                 360                 365             


Arg Ala Ser Gln Thr Tyr Phe Phe Pro Ile His Leu Thr Asp Gln Leu 
    370                 375                 380                 


Leu Pro Ser Ala Met Phe Tyr Ala Thr Val Gly Pro Leu Val Val Tyr 
385                 390                 395                 400 


Phe Ala Met His Arg Leu Ile Ile Lys Pro Tyr Leu Arg Ala Gln Lys 
                405                 410                 415     


Glu Lys Glu Leu Glu Lys Gln Arg Glu Ser Ala Ala Thr Asp Val Leu 
            420                 425                 430         


Gln Lys Lys Gln Glu Ala Glu Ser Ala Val Arg Leu Met Gln Glu Ser 
        435                 440                 445             


Val Arg Arg Ile Ile Glu Ala Glu Glu Ser Arg Met Gly Leu Ile Ile 
    450                 455                 460                 


Val Asn Ala Trp Tyr Gly Lys Phe Val Asn Asp Lys Ser Arg Lys Ser 
465                 470                 475                 480 


Glu Lys Val Lys Val Ile Asp Val Thr Val Pro Leu Gln Cys Leu Val 
                485                 490                 495     


Lys Asp Ser Lys Leu Ile Leu Thr Glu Ala Ser Lys Ala Gly Leu Pro 
            500                 505                 510         


Gly Phe Tyr Asp Pro Cys Val Gly Glu Glu Lys Asn Leu Lys Val Leu 
        515                 520                 525             


Tyr Gln Phe Arg Gly Val Leu His Gln Val Met Val Leu Asp Ser Glu 
    530                 535                 540                 


Ala Leu Arg Ile Pro Lys Gln Ser His Arg Ile Asp Thr Asp Gly 
545                 550                 555                 


<210>  8305
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNAJC11__Homo_sapiens__CCDS87.1

<400>  8305
auggcgacgg ccuugagcga ggaggagcug gacaaugaag acuauuacuc guugcugaac       60

gugcgcaggg aggccucuuc ugaagagcug aaagcugccu accggaggcu cuguaugcuc      120

uaccauccag acaagcacag agacccagag cucaagucac aggcggaacg acuguuuaac      180

cuuguucacc aggcuuauga agugcuuagu gacccccaaa ccagggccau cuaugauaua      240

uaugggaaga gaggacugga aauggaagga ugggagguug uggaaaggag gagaaccccu      300

gcugaaauuc gagaggaguu ugagcggcug cagagagaga gagaagagag gagauugcag      360

cagcgaacca aucccaaggg aacgaucagc guuggaguag augccaccga ccuuuuugau      420

cgcuaugaug aggaguauga agaugugucc ggcaguagcu uuccgcagau ugaaauuaau      480

aaaaugcaca uaucccaguc cauugaggca cccuugacag cgacagacac agccauccuc      540

ucuggaagcc ucucaaccca gaauggaaau ggaggagguu ccauuaacuu ugcgcucaga      600

cgaguaacuu cggcaaaggg auggggagag uuggaauuug gagcuggaga ccuacagggg      660

ccuuuguucg gucucaagcu guuccguaau cucacaccaa gaugcuuugu gacaacaaac      720

ugugcucugc aguuuucauc ccguggaauc cgacccggcc ugaccacugu ccuagcucgg      780

aaccuagaca agaacaccgu gggcuaccug caguggcgau gggguaucca gucagccaug      840

aacacuagca ucguccgaga cacuaaaacc agccacuuca cuguggcccu gcagcuggga      900

aucccucacu ccuuugcacu gaucagcuau cagcacaaau uccaagauga cgaucagacu      960

cgugugaaag gaucccucaa agcaggcuuc uuugggacgg ugguggagua cggagcugag     1020

aggaagaucu ccaggcacag cguuuugggu gcagcuguca gcguuggagu uccacagggu     1080

guuucucuca aagucaagcu caacagggcc agucagacau acuucuuccc uauucacuug     1140

acggaccagc uucugcccag cgccauguuc uaugccaccg uggggccucu aguggucuac     1200

uuugccaugc accgucugau caucaaacca uaccucaggg cucagaaaga gaaggaauug     1260

gagaagcaga gggaaagcgc cgccaccgau gugcugcaga agaagcaaga ggcggagucc     1320

gcuguccggc ugaugcagga aucuguccga aggauaauug aggcagaaga guccagaaug     1380

ggccucauca ucgucaaugc cugguacggg aaguuuguca augacaagag caggaagagc     1440

gagaagguga aggugauuga cgugacugug ccccugcagu gccuggugaa ggacucgaag     1500

cucauccuca cggaggccuc caaggcuggg cugccuggcu uuuaugaccc gugugugggg     1560

gaagagaaga accugaaagu gcucuaucag uuccggggcg uccugcauca ggugauggug     1620

cuggacagug aggcccuccg gauaccaaag cagucccaca ggaucgauac agauggauaa     1680


<210>  8306
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNAJC11__Homo_sapiens__CCDS87.1

<400>  8306
auggccaccg cccugagcga ggaggagcuc gacaacgagg acuacuacuc ccugcugaac       60

gugcgccggg aggcgagcuc cgaggagcuc aaggccgccu accgccggcu gugcaugcug      120

uaccaccccg acaagcaccg cgacccggag cucaagagcc aggccgagcg gcuguucaac      180

cugguccacc aggccuacga ggugcucucc gacccccaga cccgcgcgau cuacgacauc      240

uacggcaagc gggggcugga gauggagggc ugggaggugg ucgagcgccg gcgcacgccc      300

gccgagaucc gggaggaguu cgagcgccug cagcgggagc gcgaggagcg gcgccuccag      360

cagcggacca accccaaggg gaccaucagc gugggcgugg acgccaccga ccuguucgac      420

cgcuacgacg aggaguacga ggacgucucc gggagcuccu ucccgcagau cgagaucaac      480

aagaugcaca ucagccaguc caucgaggcg ccccugacgg ccaccgacac cgccauccuc      540

agcggcuccc ugagcaccca gaacggcaac gggggcgggu ccaucaacuu cgcccugcgg      600

cgcgugacga gcgccaaggg cuggggcgag cucgaguucg gggccggcga ccugcagggg      660

ccccuguucg gccucaagcu guuccggaac cugacgcccc gcugcuucgu gaccaccaac      720

ugcgcgcucc aguucuccag ccgcgggauc cggccgggcc ugaccaccgu ccuggcccgc      780

aaccucgaca agaacaccgu gggcuaccug caguggcggu gggggaucca guccgccaug      840

aacaccagca ucgugcgcga cacgaagacc agccacuuca ccgucgcccu gcagcucggc      900

aucccccacu ccuucgcccu gaucagcuac cagcacaagu uccaggacga cgaccagacc      960

cgggugaagg ggucccugaa ggcgggcuuc uucgggacgg uggucgagua cggcgccgag     1020

cgcaagauca gccggcacuc cgugcucggc gccgccguga gcgucggggu gccccagggc     1080

gugucccuga aggucaagcu gaaccgcgcc agccagaccu acuucuuccc cauccaccuc     1140

accgaccagc ugcugccguc cgcgauguuc uacgccaccg uggggccccu cguggucuac     1200

uucgccaugc accggcugau caucaagccc uaccugcgcg cccagaagga gaaggagcuc     1260

gagaagcagc gggagagcgc cgcgacggac gugcugcaga agaagcagga ggccgagucc     1320

gccguccgcc ugaugcagga gagcgugcgg cgcaucaucg aggccgagga gucccggaug     1380

ggccucauca ucgugaacgc gugguacggg aaguucguca acgacaagag ccgcaagucc     1440

gagaagguga aggugaucga cgucaccgug ccccugcagu gccuggugaa ggacagcaag     1500

cucauccuga ccgaggccuc caaggccggc cugccgggcu ucuacgaccc cugcgucggg     1560

gaggagaaga accugaaggu gcucuaccag uuccggggcg ugcugcacca ggucauggug     1620

cuggacagcg aggcccuccg cauccccaag cagucccacc ggaucgacac cgacggguga     1680


<210>  8307
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNAJC11__Homo_sapiens__CCDS87.1

<400>  8307
auggccaccg cccucuccga ggaggagcuc gacaacgagg acuacuacuc ccuccucaac       60

guccgccgcg aggccuccuc cgaggagcuc aaggccgccu accgccgccu cugcaugcuc      120

uaccaccccg acaagcaccg cgaccccgag cucaaguccc aggccgagcg ccucuucaac      180

cucguccacc aggccuacga gguccucucc gacccccaga cccgcgccau cuacgacauc      240

uacggcaagc gcggccucga gauggagggc ugggaggucg ucgagcgccg ccgcaccccc      300

gccgagaucc gcgaggaguu cgagcgccuc cagcgcgagc gcgaggagcg ccgccuccag      360

cagcgcacca accccaaggg caccaucucc gucggcgucg acgccaccga ccucuucgac      420

cgcuacgacg aggaguacga ggacgucucc ggcuccuccu ucccccagau cgagaucaac      480

aagaugcaca ucucccaguc caucgaggcc ccccucaccg ccaccgacac cgccauccuc      540

uccggcuccc ucuccaccca gaacggcaac ggcggcggcu ccaucaacuu cgcccuccgc      600

cgcgucaccu ccgccaaggg cuggggcgag cucgaguucg gcgccggcga ccuccagggc      660

ccccucuucg gccucaagcu cuuccgcaac cucacccccc gcugcuucgu caccaccaac      720

ugcgcccucc aguucuccuc ccgcggcauc cgccccggcc ucaccaccgu ccucgcccgc      780

aaccucgaca agaacaccgu cggcuaccuc caguggcgcu ggggcaucca guccgccaug      840

aacaccucca ucguccgcga caccaagacc ucccacuuca ccgucgcccu ccagcucggc      900

aucccccacu ccuucgcccu caucuccuac cagcacaagu uccaggacga cgaccagacc      960

cgcgucaagg gcucccucaa ggccggcuuc uucggcaccg ucgucgagua cggcgccgag     1020

cgcaagaucu cccgccacuc cguccucggc gccgccgucu ccgucggcgu cccccagggc     1080

gucucccuca aggucaagcu caaccgcgcc ucccagaccu acuucuuccc cauccaccuc     1140

accgaccagc uccuccccuc cgccauguuc uacgccaccg ucggcccccu cgucgucuac     1200

uucgccaugc accgccucau caucaagccc uaccuccgcg cccagaagga gaaggagcuc     1260

gagaagcagc gcgaguccgc cgccaccgac guccuccaga agaagcagga ggccgagucc     1320

gccguccgcc ucaugcagga guccguccgc cgcaucaucg aggccgagga gucccgcaug     1380

ggccucauca ucgucaacgc cugguacggc aaguucguca acgacaaguc ccgcaagucc     1440

gagaagguca aggucaucga cgucaccguc ccccuccagu gccucgucaa ggacuccaag     1500

cucauccuca ccgaggccuc caaggccggc cuccccggcu ucuacgaccc cugcgucggc     1560

gaggagaaga accucaaggu ccucuaccag uuccgcggcg uccuccacca ggucaugguc     1620

cucgacuccg aggcccuccg cauccccaag cagucccacc gcaucgacac cgacggcuga     1680


<210>  8308
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNAJC11__Homo_sapiens__CCDS87.1

<400>  8308
auggccaccg cucugagcga ggaggaacuc gacaacgaag auuacuauuc ccuucugaau       60

gugagaaggg aggcaucuuc agaagaguug aaggccgcgu accggcgcuu augcaugcug      120

uaucaccccg acaaacaucg agauccugag cuaaagaguc aggcugaacg ucucuucaac      180

cugguccacc aagccuacga gguucuuagc gacccacaga caagagcaau cuaugauauu      240

uacggcaaaa gggggcugga aauggaggga ugggaggugg uagaacggcg cagaacuccg      300

gccgagauaa gggaagaguu ugaacgguug cagcgcgagc gagaggaaag aaggcuccag      360

caacggacga aucccaaggg uaccaucucc gugggcgucg acgcuacaga ucuguucgac      420

cguuaugaug aggaauacga ggacgugucu gggucgucau uuccucagau ugaaaucaac      480

aaaaugcaua uuagccagag uaucgaggca ccacugacug ccaccgauac agcuauacuc      540

uccggaucuu uaagcaccca gaauggcaac ggugggggau ccaucaauuu cgcccugcgc      600

agaguuacuu cagcgaaggg cuggggcgag cuugaauuug gggcaggaga cuugcaaggu      660

ccccuguucg gccuaaagcu cuuuaggaac cugacaccuc gguguuucgu gaccacgaau      720

ugcgcccuuc aguuuaguag ccgagggauu cgcccaggac ugacuaccgu cuuggcuaga      780

aaccucgaua aaaauacagu gggcuaccug caguggaggu gggguaucca gucugccaug      840

aacacuucca uuguacggga caccaagaca ucacacuuca ccguugcauu acaacugggg      900

aucccccaua gcuuugcucu cauaaguuau cagcacaaau uccaggacga ugaccaaacg      960

cgcgugaagg gaucucuuaa agccggcuuu uucggcacug ucguggagua cggggcggaa     1020

agaaagauuu ccaggcacag cgugcuggga gccgcagucu cgguuggugu gccucagggc     1080

guaucuuuga aggugaaacu aaaucgugcu ucccagacau auuucuuucc aauccaucug     1140

accgaucagc uccugccguc agccauguuc uacgcuacug ucgggccccu ugugguuuau     1200

uuugccaugc accggcugau uaucaagccu uacuugcgag cacaaaaaga gaaggaacuc     1260

gagaaacaga gagagagugc cgcuacagac gugcugcaga agaaacagga agcggagagc     1320

gcagucaggu uaaugcaaga auccgugcgc cggaucauug aggccgagga aucuagaaug     1380

ggacugauaa ucguaaacgc uugguauggc aaguucguua augauaagag caggaaauca     1440

gagaagguga aagucauuga cgugaccguc ccacuacagu gucucgugaa ggauaguaaa     1500

cugauccuua cggaagccuc caaggcaggu uugcccgggu uuuacgaccc uugcguuggc     1560

gaggaaaaga accugaaagu gcucuaccag uuccgcggag uacugcauca ggucauggug     1620

cuugauagcg aggcccugcg aauaccaaag caaucucacc ggauugacac cgauggcuga     1680


<210>  8309
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNAJC11__Homo_sapiens__CCDS87.1

<400>  8309
auggccaccg cccugagcga ggaggagcug gacaacgagg acuacuacag ccugcugaac       60

gugagaagag aggccagcag cgaggagcug aaggccgccu acagaagacu gugcaugcug      120

uaccaccccg acaagcacag agaccccgag cugaagagcc aggccgagag acuguucaac      180

cuggugcacc aggccuacga ggugcugagc gacccccaga ccagagccau cuacgacauc      240

uacggcaaga gaggccugga gauggagggc ugggaggugg uggagagaag aagaaccccc      300

gccgagauca gagaggaguu cgagagacug cagagagaga gagaggagag aagacugcag      360

cagagaacca accccaaggg caccaucagc gugggcgugg acgccaccga ccuguucgac      420

agauacgacg aggaguacga ggacgugagc ggcagcagcu ucccccagau cgagaucaac      480

aagaugcaca ucagccagag caucgaggcc ccccugaccg ccaccgacac cgccauccug      540

agcggcagcc ugagcaccca gaacggcaac ggcggcggca gcaucaacuu cgcccugaga      600

agagugacca gcgccaaggg cuggggcgag cuggaguucg gcgccggcga ccugcagggc      660

ccccuguucg gccugaagcu guucagaaac cugaccccca gaugcuucgu gaccaccaac      720

ugcgcccugc aguucagcag cagaggcauc agacccggcc ugaccaccgu gcuggccaga      780

aaccuggaca agaacaccgu gggcuaccug caguggagau ggggcaucca gagcgccaug      840

aacaccagca ucgugagaga caccaagacc agccacuuca ccguggcccu gcagcugggc      900

aucccccaca gcuucgcccu gaucagcuac cagcacaagu uccaggacga cgaccagacc      960

agagugaagg gcagccugaa ggccggcuuc uucggcaccg ugguggagua cggcgccgag     1020

agaaagauca gcagacacag cgugcugggc gccgccguga gcgugggcgu gccccagggc     1080

gugagccuga aggugaagcu gaacagagcc agccagaccu acuucuuccc cauccaccug     1140

accgaccagc ugcugcccag cgccauguuc uacgccaccg ugggcccccu ggugguguac     1200

uucgccaugc acagacugau caucaagccc uaccugagag cccagaagga gaaggagcug     1260

gagaagcaga gagagagcgc cgccaccgac gugcugcaga agaagcagga ggccgagagc     1320

gccgugagac ugaugcagga gagcgugaga agaaucaucg aggccgagga gagcagaaug     1380

ggccugauca ucgugaacgc cugguacggc aaguucguga acgacaagag cagaaagagc     1440

gagaagguga aggugaucga cgugaccgug ccccugcagu gccuggugaa ggacagcaag     1500

cugauccuga ccgaggccag caaggccggc cugcccggcu ucuacgaccc cugcgugggc     1560

gaggagaaga accugaaggu gcuguaccag uucagaggcg ugcugcacca ggugauggug     1620

cuggacagcg aggcccugag aauccccaag cagagccaca gaaucgacac cgacggcuga     1680


<210>  8310
<211>  1680
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNAJC11__Homo_sapiens__CCDS87.1

<400>  8310
auggccaccg cucugagcga ggaagaacuc gacaacgaag auuacuauuc ccugcuuaau       60

gugagacggg aggccucuag cgaggagcug aaggcggcuu accgcagacu cugcaugcug      120

uaucaccccg acaaacaucg ggauccugag cuuaaguccc aggccgaacg ccuguucaac      180

cucguccacc aagccuacga gguucugucu gacccgcaga caagagcuau cuaugauauu      240

uacggcaaac gggggcugga aauggaggga ugggaggugg uggaacgcag acggacgccc      300

gccgagaucc gcgaagaguu ugaaagacuc cagcgggagc gcgaggaaag acggcugcag      360

caacgcacca auccuaaggg cacaauuagc gucggggugg acgcuaccga ucuuuucgac      420

agauaugaug aggaauacga ggacguuucc ggaucuagcu uuccccagau cgaaauuaac      480

aaaaugcaua ucucccagag caucgaggcc ccucugacag cgaccgauac agccauucuc      540

ucuggcuccc ugagcaccca gaaugggaac ggaggcggcu cuaucaauuu cgcccuucgg      600

agagugacgu ccgcuaaggg guggggagag cuggaauuug gcgcugggga ccuccaagga      660

ccccuguucg gccugaagcu cuuucgcaac cugaccccuc gguguuucgu cacaaccaau      720

ugcgcccuuc aguuuagcuc uagagggauu cgcccgggac ugacaaccgu gcucgcgcgg      780

aaccuggaua aaaauacggu uggcuaccuu caguggagau ggggcaucca guccgccaug      840

aacacaagca uugugcgcga caccaagaca ucccacuuca ccgucgcucu gcaacucggg      900

aucccccauu cuuuugcccu gauuagcuau cagcacaaau uccaggacga ugaccaaacc      960

cgggugaagg gaucccugaa agcuggcuuu uucgggacag uggucgagua cggagccgaa     1020

agaaagauca gccgccacuc uguucucggc gccgcugugu ccgugggggu cccucaggga     1080

gugagccuga agguuaaacu uaaucgggcg ucucagacgu auuucuuucc cauccaucug     1140

accgaucagc uccugccuag cgccauguuc uacgcuacag ugggcccccu ugucguguau     1200

uuugccaugc acagacugau uaucaagccg uaccuccgcg cccaaaaaga gaaggaacug     1260

gagaaacagc gggaguccgc ugccaccgac guucugcaga agaaacagga agcggagucu     1320

gcugugagac ucaugcaaga aagcguccgg cgcauuaucg aggccgagga auccagaaug     1380

ggccugauua ucgugaacgc cugguauggg aaguucguca augauaagag ccggaaaucu     1440

gagaagguga aaguuaucga cgugacaguc ccucuucagu gucuggugaa ggauuccaaa     1500

cucauucuga ccgaagcuag caaggccgga cugcccggcu uuuacgaccc uugcguuggg     1560

gaggaaaaga accuuaaagu gcucuaccag uucagaggag uccugcauca ggugauggug     1620

cuggauucug aggcucuccg cauccccaag caaucccacc ggauugacac ggauggcuga     1680


<210>  8311
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNAJC21__Homo_sapiens__Q5F1R6

<400>  8311

Met Lys Cys His Tyr Glu Ala Leu Gly Val Arg Arg Asp Ala Ser Glu 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Leu Asp Asn Ala Ala Glu Ala Ala Glu Gln Phe Lys Leu 
        35                  40                  45              


Ile Gln Ala Ala Tyr Asp Val Leu Ser Asp Pro Gln Glu Arg Ala Trp 
    50                  55                  60                  


Tyr Asp Asn His Arg Glu Ala Leu Leu Lys Gly Gly Phe Asp Gly Glu 
65                  70                  75                  80  


Tyr Gln Asp Asp Ser Leu Asp Leu Leu Arg Tyr Phe Thr Val Thr Cys 
                85                  90                  95      


Tyr Ser Gly Tyr Gly Asp Asp Glu Lys Gly Phe Tyr Thr Val Tyr Arg 
            100                 105                 110         


Asn Val Phe Glu Met Ile Ala Lys Glu Glu Leu Glu Ser Val Leu Glu 
        115                 120                 125             


Glu Glu Val Asp Asp Phe Pro Thr Phe Gly Asp Ser Gln Ser Asp Tyr 
    130                 135                 140                 


Asp Thr Val Val His Pro Phe Tyr Ala Tyr Trp Gln Ser Phe Cys Thr 
145                 150                 155                 160 


Gln Lys Asn Phe Ala Trp Lys Glu Glu Tyr Asp Thr Arg Gln Ala Ser 
                165                 170                 175     


Asn Arg Trp Glu Lys Arg Ala Met Glu Lys Glu Asn Lys Lys Ile Arg 
            180                 185                 190         


Asp Lys Ala Arg Lys Glu Lys Asn Glu Leu Val Arg Gln Leu Val Ala 
        195                 200                 205             


Phe Ile Arg Lys Arg Asp Lys Arg Val Gln Ala His Arg Lys Leu Val 
    210                 215                 220                 


Glu Glu Gln Asn Ala Glu Lys Ala Arg Lys Ala Glu Glu Met Arg Arg 
225                 230                 235                 240 


Gln Gln Lys Leu Lys Gln Ala Lys Leu Val Glu Gln Tyr Arg Glu Gln 
                245                 250                 255     


Ser Trp Met Thr Met Ala Asn Leu Glu Lys Glu Leu Gln Glu Met Glu 
            260                 265                 270         


Ala Arg Tyr Glu Lys Glu Phe Gly Asp Gly Ser Asp Glu Asn Glu Met 
        275                 280                 285             


Glu Glu His Glu Leu Lys Asp Glu Glu Asp Gly Lys Asp Ser Asp Glu 
    290                 295                 300                 


Ala Glu Asp Ala Glu Leu Tyr Asp Asp Leu Tyr Cys Pro Ala Cys Asp 
305                 310                 315                 320 


Lys Ser Phe Lys Thr Glu Lys Ala Met Lys Asn His Glu Lys Ser Lys 
                325                 330                 335     


Lys His Arg Glu Met Val Ala Leu Leu Lys Gln Gln Leu Glu Glu Glu 
            340                 345                 350         


Glu Glu Asn Phe Ser Arg Pro Gln Ile Asp Glu Asn Pro Leu Asp Asp 
        355                 360                 365             


Asn Ser Glu Glu Glu Met Glu Asp Ala Pro Lys Gln Lys Leu Ser Lys 
    370                 375                 380                 


Lys Gln Lys Lys Lys Lys Gln Lys Pro Ala Gln Asn Tyr Asp Asp Asn 
385                 390                 395                 400 


Phe Asn Val Asn Gly Pro Gly Glu Gly Val Lys Val Asp Pro Glu Asp 
                405                 410                 415     


Thr Asn Leu Asn Gln Asp Ser Ala Lys Glu Leu Glu Asp Ser Pro Gln 
            420                 425                 430         


Glu Asn Val Ser Val Thr Glu Ile Ile Lys Pro Cys Asp Asp Pro Lys 
        435                 440                 445             


Ser Glu Ala Lys Ser Val Pro Lys Pro Lys Gly Lys Lys Thr Lys Asp 
    450                 455                 460                 


Met Lys Lys Pro Val Arg Val Pro Ala Glu Pro Gln Thr Met Ser Val 
465                 470                 475                 480 


Leu Ile Ser Cys Thr Thr Cys His Ser Glu Phe Pro Ser Arg Asn Lys 
                485                 490                 495     


Leu Phe Asp His Leu Lys Ala Thr Gly His Ala Arg Ala Pro Ser Ser 
            500                 505                 510         


Ser Ser Leu Asn Ser Ala Thr Ser Ser Gln Ser Lys Lys Glu Lys Arg 
        515                 520                 525             


Lys Asn Arg 
    530     


<210>  8312
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8312
augaaguguc acuaugaggc gcugggggug cggcgcgacg ccagcgagga ggagcucaag       60

aaggccuauc ggaagcuggc ccugaaaugg cacccggaua aaaaucugga uaaugccgca      120

gaagcagcug aacaauuuaa auuaauccaa gcagcauaug auguguugag ugacccucag      180

gaaagagcau gguaugauaa ucauagagag gcccuacuua aagguggguu ugauggcgaa      240

uaucaagaug acagcuuaga uuugcuacgc uauuucaccg uuaccuguua uucugguuau      300

ggagaugaug aaaagggauu uuacacggug uaucguaaug uuuuugaaau gauugccaag      360

gaagaacuag aaucuguguu agaggaagag guugaugauu ucccaacuuu uggagacucc      420

cagagugacu augauacggu aguccauccu uucuacgcuu auuggcagag uuucugcacu      480

caaaagaauu uugcauggaa ggaagaauau gauacacgac aggcuucaaa ccgcugggaa      540

aaacgagcca uggaaaaaga aaacaaaaag auucgggaca aagcaaggaa agagaagaau      600

gagcuugucc gucagcuggu agcuuucauu cguaaaagag auaaaagagu gcaggcgcau      660

cgaaaacuug uggaagaaca gaaugcagag aaggcgagga aagccgaaga gaugaggcgg      720

cagcagaagc uaaagcaggc caaacuggug gagcaguaca gagaacagag cuggaugacu      780

auggccaauu uggagaaaga gcuccaggag auggaggcac gguacgagaa ggaguuugga      840

gauggaucgg augaaaauga aauggaagaa caugaacuca aagaugagga ggaugguaaa      900

gacagugaug aggccgagga cgcugagcuc uaugaugacc uuuacugccc agcaugugac      960

aaaucguuca agacagaaaa ggccaugaag aaucacgaga agucaaagaa gcaucgggaa     1020

augguggccu ugcuaaaaca acagcuggag gaggaagaag aaaauuuuuc aagaccucaa     1080

auugaugaaa auccauuaga ugacaauucu gaggaagaaa uggaagaugc accaaaacaa     1140

aagcuuucua aaaaacagaa gaaaaagaaa cagaaaccag cacagaauua ugaugacaau     1200

uucaauguaa auggaccugg agaaggagua aagguugauc cagaagauac uaacuuaaau     1260

caagacagug ccaaagaauu ggaagauagu ccccaggaaa augucagugu cacagagauc     1320

auuaaaccau gugaugaucc aaaaagugaa gcuaaaagug uuccuaaacc caaaggaaag     1380

aaaaccaaag auaugaaaaa accugucaga guaccugcug aaccacaaac aaugaguguu     1440

cuuaucagcu guacaaccug ccauagugaa uuuccaucuc ggaauaaacu uuuugaccau     1500

cuaaaggcca caggucaugc aagagcaccu ucaucaucgu cuuuaaacag cgcaacaagu     1560

agucaaagca agaaagagaa acguaaaaac agauag                               1596


<210>  8313
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8313
augaagugcc acuacgaggc ccugggcgug cgccgggacg ccagcgagga ggagcucaag       60

aaggcguacc gcaagcuggc ccugaagugg caccccgaca agaaccucga caacgccgcc      120

gaggccgcgg agcaguucaa gcugauccag gccgccuacg acguccuguc cgacccgcag      180

gagcgggccu gguacgacaa ccaccgcgag gcgcuccuga agggcggguu cgacggggag      240

uaccaggacg acagccugga ccuccugcgg uacuucaccg ugaccugcua cuccggcuac      300

ggggacgacg agaagggcuu cuacacggug uaccgcaacg ucuucgagau gaucgccaag      360

gaggagcugg agagcgugcu cgaggaggag guggacgacu uccccaccuu cggcgacucc      420

cagagcgacu acgacaccgu cgugcacccc uucuacgccu acuggcaguc cuucugcacc      480

cagaagaacu ucgccuggaa ggaggaguac gacacgcggc aggccagcaa ccgcugggag      540

aagcgggcga uggagaagga gaacaagaag auccgcgaca aggcccggaa ggagaagaac      600

gagcuggugc gccagcuggu cgccuucauc cggaagcgcg acaagcgggu gcaggcccac      660

cgcaagcucg uggaggagca gaacgccgag aaggcgcgga aggccgagga gaugcgccgg      720

cagcagaagc ugaagcaggc caagcugguc gagcaguacc gcgagcaguc cuggaugacc      780

auggccaacc ucgagaagga gcugcaggag auggaggccc gguacgagaa ggaguucggg      840

gacggcagcg acgagaacga gauggaggag cacgagcuga aggacgagga ggacgggaag      900

gacuccgacg aggcggagga cgccgagcuc uacgacgacc uguacugccc cgccugcgac      960

aagagcuuca agaccgagaa ggccaugaag aaccacgaga aguccaagaa gcaccgcgag     1020

augguggccc ugcucaagca gcagcuggag gaggaggagg agaacuucag ccgcccgcag     1080

aucgacgaga acccccugga cgacaacucc gaggaggaga uggaggacgc gcccaagcag     1140

aagcucagca agaagcagaa gaagaagaag cagaagcccg cccagaacua cgacgacaac     1200

uucaacguga acggcccggg ggagggcguc aagguggacc ccgaggacac caaccugaac     1260

caggacuccg ccaaggagcu ggaggacagc ccccaggaga acguguccgu cacggagauc     1320

aucaagcccu gcgacgaccc caagagcgag gccaagagcg ugccgaagcc caagggcaag     1380

aagaccaagg acaugaagaa gcccgugcgg gucccggcgg agccccagac cauguccgug     1440

cucaucagcu gcaccacgug ccacuccgag uuccccagcc gcaacaagcu guucgaccac     1500

cugaaggcca ccgggcacgc ccgggccccc uccagcucca gccucaacuc cgccaccagc     1560

ucccagagca agaaggagaa gcgcaagaac cgguga                               1596


<210>  8314
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8314
augaagugcc acuacgaggc ccucggcguc cgccgcgacg ccuccgagga ggagcucaag       60

aaggccuacc gcaagcucgc ccucaagugg caccccgaca agaaccucga caacgccgcc      120

gaggccgccg agcaguucaa gcucauccag gccgccuacg acguccucuc cgacccccag      180

gagcgcgccu gguacgacaa ccaccgcgag gcccuccuca agggcggcuu cgacggcgag      240

uaccaggacg acucccucga ccuccuccgc uacuucaccg ucaccugcua cuccggcuac      300

ggcgacgacg agaagggcuu cuacaccguc uaccgcaacg ucuucgagau gaucgccaag      360

gaggagcucg aguccguccu cgaggaggag gucgacgacu uccccaccuu cggcgacucc      420

caguccgacu acgacaccgu cguccacccc uucuacgccu acuggcaguc cuucugcacc      480

cagaagaacu ucgccuggaa ggaggaguac gacacccgcc aggccuccaa ccgcugggag      540

aagcgcgcca uggagaagga gaacaagaag auccgcgaca aggcccgcaa ggagaagaac      600

gagcucgucc gccagcucgu cgccuucauc cgcaagcgcg acaagcgcgu ccaggcccac      660

cgcaagcucg ucgaggagca gaacgccgag aaggcccgca aggccgagga gaugcgccgc      720

cagcagaagc ucaagcaggc caagcucguc gagcaguacc gcgagcaguc cuggaugacc      780

auggccaacc ucgagaagga gcuccaggag auggaggccc gcuacgagaa ggaguucggc      840

gacggcuccg acgagaacga gauggaggag cacgagcuca aggacgagga ggacggcaag      900

gacuccgacg aggccgagga cgccgagcuc uacgacgacc ucuacugccc cgccugcgac      960

aaguccuuca agaccgagaa ggccaugaag aaccacgaga aguccaagaa gcaccgcgag     1020

auggucgccc uccucaagca gcagcucgag gaggaggagg agaacuucuc ccgcccccag     1080

aucgacgaga acccccucga cgacaacucc gaggaggaga uggaggacgc ccccaagcag     1140

aagcucucca agaagcagaa gaagaagaag cagaagcccg cccagaacua cgacgacaac     1200

uucaacguca acggccccgg cgagggcguc aaggucgacc ccgaggacac caaccucaac     1260

caggacuccg ccaaggagcu cgaggacucc ccccaggaga acgucuccgu caccgagauc     1320

aucaagcccu gcgacgaccc caaguccgag gccaaguccg uccccaagcc caagggcaag     1380

aagaccaagg acaugaagaa gcccguccgc guccccgccg agccccagac cauguccguc     1440

cucaucuccu gcaccaccug ccacuccgag uuccccuccc gcaacaagcu cuucgaccac     1500

cucaaggcca ccggccacgc ccgcgccccc uccuccuccu cccucaacuc cgccaccucc     1560

ucccagucca agaaggagaa gcgcaagaac cgcuga                               1596


<210>  8315
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8315
augaagugcc acuacgaggc ccugggcgug agaagggacg cuagcgaaga ggaacucaaa       60

aaggcauauc ggaaacuugc ccugaagugg caucccgaua aaaacuugga caaugcggcu      120

gaggccgcag aacaguucaa guuaauccaa gccgcuuacg auguccuguc cgacccucag      180

gagcgcgcau gguaugauaa ccaccgagag gcccuacuca aagggggauu ugacggugaa      240

uaccaggaug acucucugga ucuucugcgu uauuucaccg uuacauguua cucaggcuau      300

ggggacgaug agaagggauu uuacacugug uacagaaaug uauucgaaau gauugcuaag      360

gaggaguugg aaagugugcu cgaggaagag gucgacgauu uuccaacguu cggcgacagc      420

caguccgacu augauaccgu gguucauccg uuuuacgccu auuggcaauc uuucugcaca      480

cagaaaaacu uugcguggaa ggaagaguac gacacuaggc aggcaucgaa ucggugggag      540

aaacgcgcca uggaaaagga gaacaagaaa auaagagaua aggcuaggaa agaaaagaau      600

gagcuggugc ggcagcuggu cgccuucauc cgcaaacgag acaagagagu gcaagcacac      660

aggaaacucg uagaagaaca gaacgcugag aaggcccgga aggcggaaga gaugcgucgc      720

cagcagaaau uaaagcaagc caaacugguu gaacaguaua gagagcaguc auggaugacc      780

auggcaaauc uugaaaagga guugcaagag auggaagcua gguacgagaa agaauuuggu      840

gaugggagcg acgagaacga gauggaggag caugaacuga aggaugagga agacggaaag      900

gauagugacg aggccgagga ugcugaacua uaugacgacc ucuacugucc cgccugcgau      960

aaauccuuca agacagagaa agcaaugaag aaucacgaaa aaucuaagaa gcaccgggag     1020

augguggccc ugcuuaaaca gcagcuggaa gaggaggaag agaacuuuag ccgaccucag     1080

auugacgaaa auccauugga ugacaacucc gaggaagaga uggaggaugc ucccaagcaa     1140

aaacucucaa agaaacagaa gaagaaaaag cagaaaccug cgcagaauua cgacgauaac     1200

uucaacguca auggcccagg cgaaggggug aagguggacc ccgaggauac caaccugaau     1260

caagacagug caaaagaauu agaggauagc ccucaggaga acgucucugu uacugaaauc     1320

auuaagccau gugacgaucc gaaauccgag gccaagucag ugcccaagcc uaaaggaaag     1380

aaaacaaagg acaugaaaaa gccaguacgc gugcccgcug aaccucagac caugagcguc     1440

cugaucaguu gcacgacuug ucauucugag uucccaucca gaaauaagcu cuuugaccac     1500

cuuaaagcca ccggucaugc aagggccccc agcucgucuu cccugaacuc agcuacaagu     1560

agccagucca agaaagaaaa gcggaaaaau cgcuga                               1596


<210>  8316
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8316
augaagugcc acuacgaggc ccugggcgug agaagagacg ccagcgagga ggagcugaag       60

aaggccuaca gaaagcuggc ccugaagugg caccccgaca agaaccugga caacgccgcc      120

gaggccgccg agcaguucaa gcugauccag gccgccuacg acgugcugag cgacccccag      180

gagagagccu gguacgacaa ccacagagag gcccugcuga agggcggcuu cgacggcgag      240

uaccaggacg acagccugga ccugcugaga uacuucaccg ugaccugcua cagcggcuac      300

ggcgacgacg agaagggcuu cuacaccgug uacagaaacg uguucgagau gaucgccaag      360

gaggagcugg agagcgugcu ggaggaggag guggacgacu uccccaccuu cggcgacagc      420

cagagcgacu acgacaccgu ggugcacccc uucuacgccu acuggcagag cuucugcacc      480

cagaagaacu ucgccuggaa ggaggaguac gacaccagac aggccagcaa cagaugggag      540

aagagagcca uggagaagga gaacaagaag aucagagaca aggccagaaa ggagaagaac      600

gagcugguga gacagcuggu ggccuucauc agaaagagag acaagagagu gcaggcccac      660

agaaagcugg uggaggagca gaacgccgag aaggccagaa aggccgagga gaugagaaga      720

cagcagaagc ugaagcaggc caagcuggug gagcaguaca gagagcagag cuggaugacc      780

auggccaacc uggagaagga gcugcaggag auggaggcca gauacgagaa ggaguucggc      840

gacggcagcg acgagaacga gauggaggag cacgagcuga aggacgagga ggacggcaag      900

gacagcgacg aggccgagga cgccgagcug uacgacgacc uguacugccc cgccugcgac      960

aagagcuuca agaccgagaa ggccaugaag aaccacgaga agagcaagaa gcacagagag     1020

augguggccc ugcugaagca gcagcuggag gaggaggagg agaacuucag cagaccccag     1080

aucgacgaga acccccugga cgacaacagc gaggaggaga uggaggacgc ccccaagcag     1140

aagcugagca agaagcagaa gaagaagaag cagaagcccg cccagaacua cgacgacaac     1200

uucaacguga acggccccgg cgagggcgug aagguggacc ccgaggacac caaccugaac     1260

caggacagcg ccaaggagcu ggaggacagc ccccaggaga acgugagcgu gaccgagauc     1320

aucaagcccu gcgacgaccc caagagcgag gccaagagcg ugcccaagcc caagggcaag     1380

aagaccaagg acaugaagaa gcccgugaga gugcccgccg agccccagac caugagcgug     1440

cugaucagcu gcaccaccug ccacagcgag uuccccagca gaaacaagcu guucgaccac     1500

cugaaggcca ccggccacgc cagagccccc agcagcagca gccugaacag cgccaccagc     1560

agccagagca agaaggagaa gagaaagaac agauga                               1596


<210>  8317
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNAJC21__Homo_sapiens__CCDS34144.1

<400>  8317
augaagugcc acuacgaggc ccugggcgug agacgggacg cuagcgaaga ggaacucaaa       60

aaggccuauc gcaaacuggc gcuuaagugg caucccgaua aaaaccugga caaugcugcc      120

gaggccgcug aacaguucaa gcucauccaa gccgcuuacg auguccuguc cgacccucag      180

gagagagccu gguaugauaa ccaccgggag gcgcuucuga aagggggauu ugacggcgaa      240

uaccaggaug acucucucga ucugcugcgc uauuucaccg uuacauguua cagcggguau      300

ggagacgaug agaagggcuu uuacacggug uacagaaaug uguucgaaau gauugccaag      360

gaggagcucg aauccguccu ggaggaagag guggacgauu uuccgaccuu cggggacucu      420

cagagcgacu augauacagu ugugcauccc uuuuacgcuu auuggcaauc cuucugcacc      480

cagaaaaacu uugccuggaa ggaagaguac gacacacggc aggcuucuaa ucgcugggag      540

aaaagagcca uggaaaagga gaacaagaaa auccgggaua aggcgcgcaa agaaaagaau      600

gagcuuguca gacagcuggu ggccuucauu cggaaacgcg acaagagagu ucaagcucac      660

cggaaacucg uggaagaaca gaacgccgag aaggcucgca aggccgaaga gaugagacgg      720

cagcagaaac ugaagcaagc caaacuuguc gaacaguaua gagagcagag cuggaugacc      780

auggcuaauc uggaaaagga gcuccaagag auggaagcgc gcuacgagaa agaauuugga      840

gauggcuccg acgagaacga gauggaggag caugaacuga aggaugagga agacggcaag      900

gauagcgacg aggccgagga ugcugaacug uaugacgacc ucuacugucc ugccugcgau      960

aaaucuuuca agacagagaa agccaugaag aaucacgaaa aauccaagaa gcaccgggag     1020

augguggcuc ugcuuaaaca gcagcuggaa gaggaggaag agaacuuuag cagaccccag     1080

aucgacgaaa auccucucga ugacaacucu gaggaagaga uggaggaugc ccccaagcaa     1140

aaacugucca agaaacagaa gaagaaaaag cagaaaccug cgcagaauua cgacgauaac     1200

uucaacguga augggccggg agaaggcguc aagguugacc ccgaggauac caaccuuaau     1260

caagacagcg cuaaagaacu ggaggauucu ccucaggaga acguguccgu gacggaaauu     1320

aucaagcccu gugacgaucc uaaaagcgag gccaaguccg uccccaagcc gaaagggaag     1380

aaaaccaagg acaugaaaaa gccugugcgc guucccgccg aaccucagac aaugucugug     1440

cucaucagcu gcaccacaug ucauuccgag uuccccagcc ggaauaagcu guuugaccac     1500

cugaaagcua ccggacaugc cagagcuccc ucuuccagcu cucucaacag cgccacgucc     1560

ucucagagca agaaagaaaa gcgcaaaaau cgguga                               1596


<210>  8318
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJA1__Homo_sapiens__P31689

<400>  8318

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
1               5                   10                  15      


Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr 
    50                  55                  60                  


Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                85                  90                  95      


Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
            100                 105                 110         


Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
        115                 120                 125             


Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
    130                 135                 140                 


Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
145                 150                 155                 160 


Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                165                 170                 175     


Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
            180                 185                 190         


Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
        195                 200                 205             


Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
    210                 215                 220                 


His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
225                 230                 235                 240 


Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                245                 250                 255     


Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
            260                 265                 270         


Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
        275                 280                 285             


Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
    290                 295                 300                 


Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
305                 310                 315                 320 


Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                325                 330                 335     


Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
            340                 345                 350         


Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
        355                 360                 365             


Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
    370                 375                 380                 


Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
385                 390                 395         


<210>  8319
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJA1__Homo_sapiens__AAC37517

<400>  8319
auggugaaag aaacaacuua cuacgauguu uuggggguca aacccaaugc uacucaggaa       60

gaauugaaaa aggcuuauag gaaacuggcc uugaaguacc auccugauaa gaacccaaau      120

gaaggagaga aguuuaaaca gauuucucaa gcuuacgaag uucucucuga ugcaaagaaa      180

agggaauuau augacaaagg aggagaacag gcaauuaaag aggguggagc agguggcggu      240

uuuggcuccc ccauggacau cuuugauaug uuuuuuggag gaggaggaag gaugcagaga      300

gaaaggagag guaaaaaugu uguacaucag cucucaguaa cccuagaaga cuuauauaau      360

ggugcaacaa gaaaacuggc ucugcaaaag aaugugauuu gugacaaaug ugaagguaga      420

ggagguaaga aaggagcagu agagugcugu cccaauugcc gagguacugg aaugcaaaua      480

agaauucauc agauaggacc uggaaugguu cagcaaauuc agucugugug cauggagugc      540

cagggccaug gggagcggau caguccuaaa gauagaugua aaagcugcaa cggaaggaag      600

auaguucgag agaagaaaau uuuagaaguu cauauugaca aaggcaugaa agauggccag      660

aagauaacau uccaugguga aggagaccaa gaaccaggac uggagccagg cgauauuauc      720

auuguguuag aucagaagga ccaugcuguu uuuacucgac gaggagaaga ccuuuucaug      780

uguauggaca uacagcucgu ugaagcacug uguggcuucc agaagccaau aucuacucuu      840

gacaaccgaa ccaucgucau caccucucau ccaggucaga uugucaagca uggagauauc      900

aaguguguac uaaaugaagg caugccaauu uaucguagac cauaugaaaa gggucgccua      960

aucaucgaau uuaagguaaa cuuuccugag aauggcuuuc ucucuccuga uaaacugucu     1020

uugcuggaaa aacuccuacc cgagaggaag gaaguggaag agacugauga gauggaccaa     1080

guagaacugg uggacuuuga uccaaaucag gaaagacggc gccacuacaa uggagaagca     1140

uaugaggaug augaacauca ucccagaggu gguguucagu gucagaccuc uuaa           1194


<210>  8320
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJA1__Homo_sapiens__AAC37517

<400>  8320
auggugaagg agaccaccua cuacgacguc cugggcguga agcccaacgc cacgcaggag       60

gagcucaaga aggccuaccg gaagcuggcg cugaaguacc acccggacaa gaaccccaac      120

gagggggaga aguucaagca gaucagccag gccuacgagg ugcucuccga cgccaagaag      180

cgggagcugu acgacaaggg cggggagcag gccaucaagg agggcggggc cggcggcggg      240

uucggcagcc ccauggacau cuucgacaug uucuucgggg gcgggggccg caugcagcgg      300

gagcgccggg gcaagaacgu cgugcaccag cuguccguga cccucgagga ccuguacaac      360

ggggcgaccc gcaagcuggc ccuccagaag aacgucaucu gcgacaagug cgagggccgc      420

gggggcaaga agggcgccgu ggagugcugc cccaacugcc gggggaccgg caugcagauc      480

cggauccacc agaucgggcc gggcauggug cagcagaucc agagcgucug cauggagugc      540

caggggcacg gcgagcgcau cucccccaag gaccggugca agagcugcaa cggccgcaag      600

aucgugcggg agaagaagau ccuggaggug cacaucgaca aggggaugaa ggacggccag      660

aagaucacgu uccacgggga gggcgaccag gagcccgggc uggagcccgg cgacaucauc      720

aucguccucg accagaagga ccacgccgug uucacccgcc ggggcgagga ccuguucaug      780

ugcauggaca uccagcuggu ggaggcgcuc ugcggguucc agaagccgau cuccacccug      840

gacaaccgca ccaucgucau cacgagccac cccggccaga ucgugaagca cggggacauc      900

aagugcgugc ugaacgaggg caugcccauc uaccggcgcc ccuacgagaa ggggcggcuc      960

aucaucgagu ucaaggucaa cuucccggag aacggcuucc ugucccccga caagcugagc     1020

cuccuggaga agcugcuccc cgagcgcaag gagguggagg agaccgacga gauggaccag     1080

guggagcugg ucgacuucga ccccaaccag gagcggcgcc gccacuacaa cggcgaggcc     1140

uacgaggacg acgagcacca cccgcgcggg ggcgugcagu gccagaccuc cuga           1194


<210>  8321
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJA1__Homo_sapiens__AAC37517

<400>  8321
auggucaagg agaccaccua cuacgacguc cucggcguca agcccaacgc cacccaggag       60

gagcucaaga aggccuaccg caagcucgcc cucaaguacc accccgacaa gaaccccaac      120

gagggcgaga aguucaagca gaucucccag gccuacgagg uccucuccga cgccaagaag      180

cgcgagcucu acgacaaggg cggcgagcag gccaucaagg agggcggcgc cggcggcggc      240

uucggcuccc ccauggacau cuucgacaug uucuucggcg gcggcggccg caugcagcgc      300

gagcgccgcg gcaagaacgu cguccaccag cucuccguca cccucgagga ccucuacaac      360

ggcgccaccc gcaagcucgc ccuccagaag aacgucaucu gcgacaagug cgagggccgc      420

ggcggcaaga agggcgccgu cgagugcugc cccaacugcc gcggcaccgg caugcagauc      480

cgcauccacc agaucggccc cggcaugguc cagcagaucc aguccgucug cauggagugc      540

cagggccacg gcgagcgcau cucccccaag gaccgcugca aguccugcaa cggccgcaag      600

aucguccgcg agaagaagau ccucgagguc cacaucgaca agggcaugaa ggacggccag      660

aagaucaccu uccacggcga gggcgaccag gagcccggcc ucgagcccgg cgacaucauc      720

aucguccucg accagaagga ccacgccguc uucacccgcc gcggcgagga ccucuucaug      780

ugcauggaca uccagcucgu cgaggcccuc ugcggcuucc agaagcccau cuccacccuc      840

gacaaccgca ccaucgucau caccucccac cccggccaga ucgucaagca cggcgacauc      900

aagugcgucc ucaacgaggg caugcccauc uaccgccgcc ccuacgagaa gggccgccuc      960

aucaucgagu ucaaggucaa cuuccccgag aacggcuucc ucucccccga caagcucucc     1020

cuccucgaga agcuccuccc cgagcgcaag gaggucgagg agaccgacga gauggaccag     1080

gucgagcucg ucgacuucga ccccaaccag gagcgccgcc gccacuacaa cggcgaggcc     1140

uacgaggacg acgagcacca cccccgcggc ggcguccagu gccagaccuc cuga           1194


<210>  8322
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJA1__Homo_sapiens__AAC37517

<400>  8322
auggugaagg agaccacaua cuaugacguc cugggcguua aacccaacgc cacucaggag       60

gaacucaaga aggcuuacag aaaacuugca cugaaauauc acccugauaa gaauccaaac      120

gaaggggaga aguucaaaca aaucagccag gccuacgaag uguuguccga cgcgaagaaa      180

agggaguuau augauaaggg aggugagcag gcuauuaaag aaggcggggc cggaggcggu      240

uuugggucuc cgauggacau auucgauaug uuuuucggag gcggcgggcg gaugcagcgc      300

gagcgacgug gaaagaaugu agugcaucaa cugucaguca cgcuagaaga ccucuacaac      360

ggugcaacca gaaagcuggc ccuucagaaa aaugugaucu gcgauaagug ugagggcagg      420

ggagggaaaa agggcgcugu ugagugcugu cccaacugcc gggguacagg gaugcagauu      480

cgcauccacc agauuggacc uggcauggug caacagaucc agagugucug uauggaaugc      540

cagggccaug gggagagaau aagcccaaaa gacaggugua aguccugcaa uggacggaaa      600

aucgugcgcg aaaagaagau ucuggaggua cacaucgaua aagguaugaa ggacggccag      660

aaaauuacuu uucaugggga aggagaucaa gagcccggcu uggagccugg ugacaucaua      720

auuguucucg aucagaagga ccacgcagug uucacccgaa gaggggaaga ccuguuuaug      780

uguauggaua uccaacuggu cgaggcccuc ugcggcuucc agaaaccaau uucuacauua      840

gacaacagga ccaucgugau cacuucgcac cccggacaga uugugaagca uggcgauaua      900

aagugugucc ugaaugaagg gaugccuauc uaucggcguc cauacgagaa aggacgccuu      960

auuaucgaau uuaagguuaa cuucccggag aauggcuuuu ugucacccga caaacugagc     1020

cuacucgaga agcugcuucc ugaaagaaaa gagguggaag agacagauga aauggaccag     1080

guagagcugg uggauuucga cccaaaccaa gagaggcggc gacacuacaa uggugaggcu     1140

uaugaagaug acgaacauca cccccgcggg ggaguccagu gccagaccag uuga           1194


<210>  8323
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJA1__Homo_sapiens__AAC37517

<400>  8323
auggugaagg agaccaccua cuacgacgug cugggcguga agcccaacgc cacccaggag       60

gagcugaaga aggccuacag aaagcuggcc cugaaguacc accccgacaa gaaccccaac      120

gagggcgaga aguucaagca gaucagccag gccuacgagg ugcugagcga cgccaagaag      180

agagagcugu acgacaaggg cggcgagcag gccaucaagg agggcggcgc cggcggcggc      240

uucggcagcc ccauggacau cuucgacaug uucuucggcg gcggcggcag aaugcagaga      300

gagagaagag gcaagaacgu ggugcaccag cugagcguga cccuggagga ccuguacaac      360

ggcgccacca gaaagcuggc ccugcagaag aacgugaucu gcgacaagug cgagggcaga      420

ggcggcaaga agggcgccgu ggagugcugc cccaacugca gaggcaccgg caugcagauc      480

agaauccacc agaucggccc cggcauggug cagcagaucc agagcgugug cauggagugc      540

cagggccacg gcgagagaau cagccccaag gacagaugca agagcugcaa cggcagaaag      600

aucgugagag agaagaagau ccuggaggug cacaucgaca agggcaugaa ggacggccag      660

aagaucaccu uccacggcga gggcgaccag gagcccggcc uggagcccgg cgacaucauc      720

aucgugcugg accagaagga ccacgccgug uucaccagaa gaggcgagga ccuguucaug      780

ugcauggaca uccagcuggu ggaggcccug ugcggcuucc agaagcccau cagcacccug      840

gacaacagaa ccaucgugau caccagccac cccggccaga ucgugaagca cggcgacauc      900

aagugcgugc ugaacgaggg caugcccauc uacagaagac ccuacgagaa gggcagacug      960

aucaucgagu ucaaggugaa cuuccccgag aacggcuucc ugagccccga caagcugagc     1020

cugcuggaga agcugcugcc cgagagaaag gagguggagg agaccgacga gauggaccag     1080

guggagcugg uggacuucga ccccaaccag gagagaagaa gacacuacaa cggcgaggcc     1140

uacgaggacg acgagcacca ccccagaggc ggcgugcagu gccagaccag cuga           1194


<210>  8324
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJA1__Homo_sapiens__AAC37517

<400>  8324
auggugaagg agaccacaua cuaugacguc cugggcguua aacccaacgc cacgcaggag       60

gaacucaaga aggcuuacag aaaacuggcc cuuaaauauc acccugauaa gaauccgaac      120

gaaggggaga aguucaaaca aaucagccag gcguacgaag ugcuguccga cgcuaagaaa      180

cgggagcucu augauaaggg aggcgagcag gccauuaaag aagggggagc cggcggggga      240

uuuggcucuc ccauggacau cuucgauaug uuuuucggcg ggggaggccg caugcagaga      300

gagcggcgcg ggaagaaugu gguccaucaa cugagcguga cccuugaaga ccuguacaac      360

ggagcuacaa gaaagcucgc ccugcagaaa aauguuauuu gcgauaagug ugagggcaga      420

gggggcaaaa agggagcugu ggagugcugu ccuaacugcc gcggcaccgg gaugcagauc      480

cggauucacc agaucggacc cggcaugguc caacagaucc aguccgugug uauggaaugc      540

caggggcaug gagagcggau uucuccuaaa gaccgcugua agagcugcaa uggcagaaaa      600

aucguucggg aaaagaagau ucuggaggug cacaucgaua aagggaugaa ggacggacag      660

aaaauuacau uucauggcga aggcgaucaa gagcccgggc ucgagccugg agacaucauu      720

aucguccugg aucagaagga ccacgccgug uucacccgca gaggcgaaga ccuuuuuaug      780

uguauggaua uccaacuggu ggaggcgcuc ugcggguucc agaaaccgau uuccacacug      840

gacaaccgga ccaucgucau uacgucucac cccggacaga ucguuaagca uggcgauauu      900

aagugugugc uuaaugaagg gaugccuauc uaucgcagac ccuacgagaa aggccggcug      960

aucauugaau uuaaggugaa cuucccugag aauggauuuc ucagccccga caaacugucc     1020

cugcucgaga agcugcuucc ggaaagaaaa gaggucgaag agaccgauga aauggaccag     1080

guggagcugg uugauuucga cccuaaccaa gagcgccgga gacacuacaa uggcgaagcc     1140

uaugaggaug acgaacauca cccccgcggg ggagugcagu gccagacaag cuga           1194


<210>  8325
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJA2__Homo_sapiens__O60884

<400>  8325

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
1               5                   10                  15      


Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
            20                  25                  30          


Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
        35                  40                  45              


Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
    50                  55                  60                  


Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                85                  90                  95      


Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
            100                 105                 110         


Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
        115                 120                 125             


Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
    130                 135                 140                 


Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
145                 150                 155                 160 


Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                165                 170                 175     


Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
            180                 185                 190         


Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
        195                 200                 205             


Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
    210                 215                 220                 


Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
225                 230                 235                 240 


Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu 
                245                 250                 255     


His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
            260                 265                 270         


Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
        275                 280                 285             


Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
    290                 295                 300                 


Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
305                 310                 315                 320 


Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                325                 330                 335     


Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
            340                 345                 350         


Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr 
        355                 360                 365             


Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
385                 390                 395                 400 


Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                405                 410         


<210>  8326
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJA2__Homo_sapiens__AAH13044

<400>  8326
auggcuaacg uggcugacac gaagcuguac gacauccugg gcgucccgcc cggcgccagc       60

gagaacgagc ugaagaaggc auacagaaag uuagccaagg aauaucaucc ugauaagaau      120

ccaaaugcag gagacaaauu uaaagaaaua aguuuugcau augaaguacu aucaaauccu      180

gagaagcgug aguuauauga cagauacgga gagcaagguc uucgggaagg cagcggcgga      240

ggugguggca uggaugauau uuucucucac auuuuuggug ggggauuguu cggcuucaug      300

ggcaaucaga guagaagucg aaauggcaga agaagaggag aggacaugau gcauccacuc      360

aaaguaucuu uagaagaucu guauaauggc aagacaacca aacuacaacu uagcaagaau      420

gugcucugua gugcaugcag uggccaaggc ggaaagucug gagcugucca aaaguguagu      480

gcuugucgag gucgaggugu gcgcaucaug aucagacagc uggcuccagg gaugguacaa      540

cagaugcagu cugugugcuc ugauuguaau ggagaaggag agguaauuaa ugaaaaagac      600

cgcuguaaaa aaugugaagg gaagaaggug auuaaagaag ucaagauucu ugaaguccac      660

guagacaaag gcaugaaaca uggacagaga auuacauuca cuggggaagc agaccaggcc      720

ccaggagugg aacccggaga cauuguucuu uugcuacagg agaaagaaca ugagguauuu      780

cagagagaug ggaaugauuu gcacaugaca uauaaaauag gacuuguuga agcucuaugu      840

ggauuucagu ucacauuuaa gcaccuugau ggacgucaga uuguggugaa auaccccccu      900

ggcaaaguaa uugaaccagg guguguucgu guaguucgag gugaagggau gccgcaguau      960

cguaaucccu uugaaaaagg ugaucuuuac auaaaguuug augugcaguu uccugaaaac     1020

aacuggauca acccagacaa gcuuucugaa cuagaagauc uucugccauc uagaccggaa     1080

guuccuaaca uaauuggaga aacagaggag guagagcuuc aggaauuuga uagcacucga     1140

ggcucaggag guggucagag gcgugaagcc uauaaugaua gcucugauga agaaagcagc     1200

agccaucaug gaccuggagu gcagugugcc caucaguaa                            1239


<210>  8327
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJA2__Homo_sapiens__AAH13044

<400>  8327
auggccaacg uggccgacac caagcuguac gacauccucg gcgugccccc gggggcgagc       60

gagaacgagc ugaagaaggc cuaccgcaag cuggccaagg aguaccaccc cgacaagaac      120

cccaacgccg gcgacaaguu caaggagauc uccuucgccu acgagguccu cagcaacccc      180

gagaagcggg agcuguacga ccgcuacggg gagcagggcc ugcgggaggg guccggcggc      240

gggggcggga uggacgacau cuucagccac aucuucggcg ggggccucuu cggcuucaug      300

gggaaccagu cccgcagccg gaacggccgc cggcgcgggg aggacaugau gcacccgcug      360

aagguguccc uggaggaccu cuacaacggc aagaccacga agcugcagcu gagcaagaac      420

guccucugcu ccgcgugcag cggccagggc gggaaguccg gggccgugca gaagugcagc      480

gccugccggg gccgcggggu gcggaucaug auccgccagc uggcccccgg caugguccag      540

cagaugcagu ccgugugcag cgacugcaac ggcgaggggg aggugaucaa cgagaaggac      600

cggugcaaga agugcgaggg caagaagguc aucaaggagg ugaagauccu ggaggugcac      660

gucgacaagg ggaugaagca cggccagcgc aucaccuuca ccggggaggc ggaccaggcc      720

cccggcgugg agcccggcga caucgugcuc cugcugcagg agaaggagca cgaggucuuc      780

cagcgggacg ggaacgaccu ccacaugacc uacaagaucg gccuggugga ggcccugugc      840

ggguuccagu ucacguucaa gcaccucgac ggccgccaga ucguggucaa guacccgccc      900

gggaagguga ucgagcccgg cugcgugcgg gucgugcgcg gcgaggggau gccccaguac      960

cggaacccgu ucgagaaggg cgaccuguac aucaaguucg acgugcaguu ccccgagaac     1020

aacuggauca accccgacaa gcuguccgag cucgaggacc ugcugcccag ccgcccggag     1080

guccccaaca ucaucgggga gaccgaggag guggagcucc aggaguucga cuccacccgg     1140

ggcagcggcg ggggccagcg ccgcgaggcc uacaacgacu ccagcgacga ggagagcucc     1200

agccaccacg ggcccggcgu ccagugcgcc caccaguga                            1239


<210>  8328
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJA2__Homo_sapiens__AAH13044

<400>  8328
auggccaacg ucgccgacac caagcucuac gacauccucg gcgucccccc cggcgccucc       60

gagaacgagc ucaagaaggc cuaccgcaag cucgccaagg aguaccaccc cgacaagaac      120

cccaacgccg gcgacaaguu caaggagauc uccuucgccu acgagguccu cuccaacccc      180

gagaagcgcg agcucuacga ccgcuacggc gagcagggcc uccgcgaggg cuccggcggc      240

ggcggcggca uggacgacau cuucucccac aucuucggcg gcggccucuu cggcuucaug      300

ggcaaccagu cccgcucccg caacggccgc cgccgcggcg aggacaugau gcacccccuc      360

aaggucuccc ucgaggaccu cuacaacggc aagaccacca agcuccagcu cuccaagaac      420

guccucugcu ccgccugcuc cggccagggc ggcaaguccg gcgccgucca gaagugcucc      480

gccugccgcg gccgcggcgu ccgcaucaug auccgccagc ucgcccccgg caugguccag      540

cagaugcagu ccgucugcuc cgacugcaac ggcgagggcg aggucaucaa cgagaaggac      600

cgcugcaaga agugcgaggg caagaagguc aucaaggagg ucaagauccu cgagguccac      660

gucgacaagg gcaugaagca cggccagcgc aucaccuuca ccggcgaggc cgaccaggcc      720

cccggcgucg agcccggcga caucguccuc cuccuccagg agaaggagca cgaggucuuc      780

cagcgcgacg gcaacgaccu ccacaugacc uacaagaucg gccucgucga ggcccucugc      840

ggcuuccagu ucaccuucaa gcaccucgac ggccgccaga ucgucgucaa guaccccccc      900

ggcaagguca ucgagcccgg cugcguccgc gucguccgcg gcgagggcau gccccaguac      960

cgcaaccccu ucgagaaggg cgaccucuac aucaaguucg acguccaguu ccccgagaac     1020

aacuggauca accccgacaa gcucuccgag cucgaggacc uccuccccuc ccgccccgag     1080

guccccaaca ucaucggcga gaccgaggag gucgagcucc aggaguucga cuccacccgc     1140

ggcuccggcg gcggccagcg ccgcgaggcc uacaacgacu ccuccgacga ggaguccucc     1200

ucccaccacg gccccggcgu ccagugcgcc caccaguga                            1239


<210>  8329
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJA2__Homo_sapiens__AAH13044

<400>  8329
auggccaacg uggcugacac caagcuguac gauauccucg gcguuccccc uggggcaagc       60

gagaaugaac uuaaaaaggc cuauagaaaa cuggcgaagg aguaccaccc agacaaaaac      120

ccgaaugcug gagauaaguu caaggaaauu uccuuugccu augaggucuu gucuaacccc      180

gagaaaaggg aauuauacga ccgguauggu gagcagggcc ugcgcgaagg gucaggaggc      240

ggugggggaa uggaugacau auucagucau aucuuuggcg gcgggcuauu cggauuuaug      300

gguaaucaaa gccgaucccg uaacggcaga aggcgcgggg aggauaugau gcacccucuc      360

aaggugucuc uggaagaccu uuacaaugga aaaacaacua agcugcaguu gucgaaaaac      420

guacucugcu cagcauguag cggccagggu gggaagagug gagccgugca gaagugcucc      480

gcuugucggg gcagaggcgu caggauuaug auccggcaac uggcaccagg gauggugcag      540

cagaugcagu cuguuugcag cgauuguaau ggagagggug aggugauuaa cgaaaaagac      600

cgcugcaaga aaugugaggg caagaaaguc aucaaggaag ugaaaauacu ggagguacau      660

guugauaagg ggaugaagca cggacaacga aucacguuca ccggcgaagc cgaccaggcu      720

cccggugugg agccugggga uauuguccuc uuacugcagg agaaagaaca ugagguguuu      780

cagagagacg gcaaugaccu ucacaugaca uauaagaucg gauuggugga agcccugugc      840

ggcuuccaau uuacuuucaa acaccuagau gggaggcaga uugucguuaa guacccaccc      900

ggaaaaguga ucgagccugg uuguguacgg gugguccgug gcgaagggau gccacaguac      960

cgcaacccgu uugagaaggg agaccucuau auaaaguucg augugcaauu ucccgagaau     1020

aacuggauua auccugacaa acuguccgaa cuugaggauc uguugccauc aagacccgaa     1080

guuccuaaca ucauuggcga gaccgaagag guggagcucc aggaguucga caguacaagg     1140

gguagcgggg gcggacagcg gcgagaagcg uacaacgauu cuuccgacga agagucaagc     1200

agucaucacg gcccaggggu ccagugcgca caucaauga                            1239


<210>  8330
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJA2__Homo_sapiens__AAH13044

<400>  8330
auggccaacg uggccgacac caagcuguac gacauccugg gcgugccccc cggcgccagc       60

gagaacgagc ugaagaaggc cuacagaaag cuggccaagg aguaccaccc cgacaagaac      120

cccaacgccg gcgacaaguu caaggagauc agcuucgccu acgaggugcu gagcaacccc      180

gagaagagag agcuguacga cagauacggc gagcagggcc ugagagaggg cagcggcggc      240

ggcggcggca uggacgacau cuucagccac aucuucggcg gcggccuguu cggcuucaug      300

ggcaaccaga gcagaagcag aaacggcaga agaagaggcg aggacaugau gcacccccug      360

aaggugagcc uggaggaccu guacaacggc aagaccacca agcugcagcu gagcaagaac      420

gugcugugca gcgccugcag cggccagggc ggcaagagcg gcgccgugca gaagugcagc      480

gccugcagag gcagaggcgu gagaaucaug aucagacagc uggcccccgg cauggugcag      540

cagaugcaga gcgugugcag cgacugcaac ggcgagggcg aggugaucaa cgagaaggac      600

agaugcaaga agugcgaggg caagaaggug aucaaggagg ugaagauccu ggaggugcac      660

guggacaagg gcaugaagca cggccagaga aucaccuuca ccggcgaggc cgaccaggcc      720

cccggcgugg agcccggcga caucgugcug cugcugcagg agaaggagca cgagguguuc      780

cagagagacg gcaacgaccu gcacaugacc uacaagaucg gccuggugga ggcccugugc      840

ggcuuccagu ucaccuucaa gcaccuggac ggcagacaga ucguggugaa guaccccccc      900

ggcaagguga ucgagcccgg cugcgugaga guggugagag gcgagggcau gccccaguac      960

agaaaccccu ucgagaaggg cgaccuguac aucaaguucg acgugcaguu ccccgagaac     1020

aacuggauca accccgacaa gcugagcgag cuggaggacc ugcugcccag cagacccgag     1080

gugcccaaca ucaucggcga gaccgaggag guggagcugc aggaguucga cagcaccaga     1140

ggcagcggcg gcggccagag aagagaggcc uacaacgaca gcagcgacga ggagagcagc     1200

agccaccacg gccccggcgu gcagugcgcc caccaguga                            1239


<210>  8331
<211>  1239
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJA2__Homo_sapiens__AAH13044

<400>  8331
auggccaacg uggcugacac caagcuguac gauauccucg gcguuccccc uggggccagc       60

gagaaugaac ugaaaaaggc guauagaaaa cuugcuaagg aguaccaccc ggacaaaaac      120

cccaaugccg gagauaaguu caaggaaauu uccuuugccu augagguccu gucuaacccu      180

gaaaaacggg agcucuacga ccgcuauggc gagcaggggc ugagagaagg aagcggcggg      240

ggaggcggca uggaugacau cuucucccau auuuuugggg gaggccuuuu cggguuuaug      300

ggaaaucaau cucggagccg caacggcaga cggcgcgggg aggauaugau gcacccccug      360

aagguguccc ucgaagaccu guacaaugga aaaacaacga agcugcagcu cucuaaaaac      420

gugcugugca gcgcuuguuc cggccagggc ggaaagagcg gggccgucca gaagugcucu      480

gcuuguagag gccgcggggu gcggaucaug auuagacaac uugccccugg aaugguucag      540

cagaugcagu ccgugugcag cgauuguaau ggcgaggggg aggucaucaa cgaaaaagac      600

cggugcaaga aaugugaggg aaagaaagug aucaaggaag uuaaaauucu ggaggugcau      660

gucgauaagg gcaugaagca cggccaacgc aucaccuuca caggggaagc ggaccaggcc      720

cccggagugg agccuggcga uauugugcuc cugcuucagg agaaagaaca ugaggucuuu      780

cagagagacg ggaaugaccu gcacaugacc uauaagaucg gacucguuga agcucugugc      840

ggcuuccaau uuacauucaa acaccuggau gggcggcaga uuguggugaa guacccgccc      900

ggcaaaguca ucgagccugg augugugcgc guugugagag gcgaagggau gccccaguac      960

cggaacccuu uugagaaggg agaccucuau auuaaguucg auguccaauu ucccgagaau     1020

aacuggauca auccggacaa acugucugaa cuugaggauc ugcucccuuc cagacccgaa     1080

gugccuaaca ucauuggcga gaccgaagag guugagcugc aggaguucga cagcacacgc     1140

gggucuggag gcgggcagcg gagagaagcc uacaacgauu ccagcgacga agaguccucu     1200

agccaucacg gccccggagu gcagugcgcu caucaauga                            1239


<210>  8332
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJA3__Homo_sapiens__Q96EY1

<400>  8332

Met Ala Ala Arg Cys Ser Thr Arg Trp Leu Leu Val Val Val Gly Thr 
1               5                   10                  15      


Pro Arg Leu Pro Ala Ile Ser Gly Arg Gly Ala Arg Pro Pro Arg Glu 
            20                  25                  30          


Gly Val Val Gly Ala Trp Leu Ser Arg Lys Leu Ser Val Pro Ala Phe 
        35                  40                  45              


Ala Ser Ser Leu Thr Ser Cys Gly Pro Arg Ala Leu Leu Thr Leu Arg 
    50                  55                  60                  


Pro Gly Val Ser Leu Thr Gly Thr Lys His Asn Pro Phe Ile Cys Thr 
65                  70                  75                  80  


Ala Ser Phe His Thr Ser Ala Pro Leu Ala Lys Glu Asp Tyr Tyr Gln 
                85                  90                  95      


Ile Leu Gly Val Pro Arg Asn Ala Ser Gln Lys Glu Ile Lys Lys Ala 
            100                 105                 110         


Tyr Tyr Gln Leu Ala Lys Lys Tyr His Pro Asp Thr Asn Lys Asp Asp 
        115                 120                 125             


Pro Lys Ala Lys Glu Lys Phe Ser Gln Leu Ala Glu Ala Tyr Glu Val 
    130                 135                 140                 


Leu Ser Asp Glu Val Lys Arg Lys Gln Tyr Asp Ala Tyr Gly Ser Ala 
145                 150                 155                 160 


Gly Phe Asp Pro Gly Ala Ser Gly Ser Gln His Ser Tyr Trp Lys Gly 
                165                 170                 175     


Gly Pro Thr Val Asp Pro Glu Glu Leu Phe Arg Lys Ile Phe Gly Glu 
            180                 185                 190         


Phe Ser Ser Ser Ser Phe Gly Asp Phe Gln Thr Val Phe Asp Gln Pro 
        195                 200                 205             


Gln Glu Tyr Phe Met Glu Leu Thr Phe Asn Gln Ala Ala Lys Gly Val 
    210                 215                 220                 


Asn Lys Glu Phe Thr Val Asn Ile Met Asp Thr Cys Glu Arg Cys Asn 
225                 230                 235                 240 


Gly Lys Gly Asn Glu Pro Gly Thr Lys Val Gln His Cys His Tyr Cys 
                245                 250                 255     


Gly Gly Ser Gly Met Glu Thr Ile Asn Thr Gly Pro Phe Val Met Arg 
            260                 265                 270         


Ser Thr Cys Arg Arg Cys Gly Gly Arg Gly Ser Ile Ile Ile Ser Pro 
        275                 280                 285             


Cys Val Val Cys Arg Gly Ala Gly Gln Ala Lys Gln Lys Lys Arg Val 
    290                 295                 300                 


Met Ile Pro Val Pro Ala Gly Val Glu Asp Gly Gln Thr Val Arg Met 
305                 310                 315                 320 


Pro Val Gly Lys Arg Glu Ile Phe Ile Thr Phe Arg Val Gln Lys Ser 
                325                 330                 335     


Pro Val Phe Arg Arg Asp Gly Ala Asp Ile His Ser Asp Leu Phe Ile 
            340                 345                 350         


Ser Ile Ala Gln Ala Leu Leu Gly Gly Thr Ala Arg Ala Gln Gly Leu 
        355                 360                 365             


Tyr Glu Thr Ile Asn Val Thr Ile Pro Pro Gly Thr Gln Thr Asp Gln 
    370                 375                 380                 


Lys Ile Arg Met Gly Gly Lys Gly Ile Pro Arg Ile Asn Ser Tyr Gly 
385                 390                 395                 400 


Tyr Gly Asp His Tyr Ile His Ile Lys Ile Arg Val Pro Lys Arg Leu 
                405                 410                 415     


Thr Ser Arg Gln Gln Ser Leu Ile Leu Ser Tyr Ala Glu Asp Glu Thr 
            420                 425                 430         


Asp Val Glu Gly Thr Val Asn Gly Val Thr Leu Thr Ser Ser Gly Gly 
        435                 440                 445             


Ser Thr Met Asp Ser Ser Ala Gly Ser Lys Ala Arg Arg Glu Ala Gly 
    450                 455                 460                 


Glu Asp Glu Glu Gly Phe Leu Ser Lys Leu Lys Lys Met Phe Thr Ser 
465                 470                 475                 480 






<210>  8333
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJA3__Homo_sapiens__AAC29066

<400>  8333
auggcugcgc ggugcuccac acgcugguug cuggugguug uggggacccc gcggcugccg       60

gcuauaucgg guagaggggc ccggccgccc agggagggcg uggugggggc auggcugagc      120

cgcaagcuga gcguccccgc cuuugcgucu ucccugaccu cuugcggccc ccgagcgcug      180

cugacauuga gaccuggugu cagccuuaca ggaacaaaac auaacccuuu cauuuguacu      240

gccuccuucc acacgagugc cccuuuggcc aaagaagauu auuaucagau auuaggagug      300

ccucgaaaug ccagccagaa agagaucaag aaagccuauu aucagcuugc caagaaguau      360

cacccugaca caaauaagga ugaucccaaa gccaaggaga aguucuccca gcuggcagaa      420

gccuaugagg uuuugaguga ugaggugaag aggaagcagu acgaugccua cggcucugca      480

ggcuucgauc cuggggccag cggcucccag cauagcuacu ggaagggagg ccccacugug      540

gaccccgagg agcuguucag gaagaucuuu ggcgaguucu cauccucuuc auuuggagau      600

uuccagaccg uguuugauca gccucaggaa uacuucaugg aguugacauu caaucaagcu      660

gcaaaggggg ucaacaagga guucaccgug aacaucaugg acacguguga gcgcugcaac      720

ggcaagggga acgagcccgg caccaaggug cagcauugcc acuacugugg cggcuccggc      780

auggaaacca ucaacacagg cccuuuugug augcguucca cguguaggag augugguggc      840

cgcggcucca ucaucauauc gcccugugug gucugcaggg gagcaggaca agccaagcag      900

aaaaagcgag ugaugauccc ugugccugca ggagucgagg auggccagac cgugaggaug      960

ccugugggaa aaagggaaau uuucauuacg uucagggugc agaaaagccc uguguuccgg     1020

agggacggcg cagacaucca cuccgaccuc uuuauuucua uagcucaggc ucuucuuggg     1080

ggaacagcca gagcccaggg ccuguacgag acgaucaacg ugacgauccc cccugggacu     1140

cagacagacc agaagauucg gauggguggg aaaggcaucc cccggauuaa cagcuacggc     1200

uacggagacc acuacaucca caucaagaua cgaguuccaa agaggcuaac gagccggcag     1260

cagagccuga uccugagcua cgccgaggac gagacagaug uggaggggac ggugaacggc     1320

gucacccuca ccagcucugg uggcagcacc auggauagcu ccgcaggaag caaggcuagg     1380

cgugaggcug gggaggacga ggagggauuc cuuuccaaac uuaagaaaau guuuaccuca     1440

uga                                                                   1443


<210>  8334
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJA3__Homo_sapiens__AAC29066

<400>  8334
auggccgccc gcugcagcac ccgguggcug cucguggucg ugggcacgcc ccgccugccg       60

gcgaucuccg ggcggggcgc ccgcccgccc cgggaggggg uggucggcgc cuggcugagc      120

cgcaagcucu ccgugcccgc cuucgccagc ucccugacca gcugcgggcc ccgggcgcug      180

cucacccugc gccccggcgu gucccugacc ggcaccaagc acaaccccuu caucugcacg      240

gccagcuucc acaccuccgc gccccucgcc aaggaggacu acuaccagau ccuggggguc      300

ccgcggaacg ccagccagaa ggagaucaag aaggccuacu accagcuggc caagaaguac      360

caccccgaca ccaacaagga cgaccccaag gccaaggaga aguucuccca gcucgccgag      420

gcguacgagg ugcugagcga cgaggugaag cgcaagcagu acgacgccua cggcuccgcc      480

ggguucgacc ccggcgccag cgggucccag cacagcuacu ggaagggcgg cccgaccguc      540

gaccccgagg agcuguuccg gaagaucuuc ggggaguucu ccagcuccag cuucggcgac      600

uuccagacgg uguucgacca gccccaggag uacuucaugg agcucaccuu caaccaggcc      660

gcgaaggggg ugaacaagga guucaccguc aacaucaugg acacgugcga gcgcugcaac      720

ggcaagggca acgagcccgg gaccaaggug cagcacugcc acuacugcgg cgggagcggc      780

auggagacca ucaacaccgg gccguucgug augcggucca cgugccgccg gugcggcggc      840

cgcgggagca ucaucaucuc ccccugcguc gugugccggg gcgccgggca ggccaagcag      900

aagaagcgcg ugaugauccc cguccccgcc ggcguggagg acgggcagac cgugcggaug      960

ccggucggca agcgcgagau cuucaucacc uuccgggugc agaagucccc cguguuccgc     1020

cgcgacggcg ccgacaucca cagcgaccug uucaucagca ucgcgcaggc ccugcucggg     1080

ggcaccgccc gggcccaggg gcuguacgag accaucaacg ucacgauccc gcccggcacc     1140

cagaccgacc agaagauccg caugggcggg aagggcaucc cccggaucaa cuccuacggg     1200

uacggcgacc acuacaucca caucaagauc cgcgugccca agcggcugac cagccgccag     1260

cagucccuca uccugagcua cgccgaggac gagacggacg ucgaggggac cgugaacggc     1320

gugacccuga ccuccagcgg cggguccacg auggacagcu ccgcgggcag caaggcccgg     1380

cgcgaggccg gggaggacga ggagggcuuc cucuccaagc ugaagaagau guucaccagc     1440

uga                                                                   1443


<210>  8335
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJA3__Homo_sapiens__AAC29066

<400>  8335
auggccgccc gcugcuccac ccgcuggcuc cucgucgucg ucggcacccc ccgccucccc       60

gccaucuccg gccgcggcgc ccgccccccc cgcgagggcg ucgucggcgc cuggcucucc      120

cgcaagcucu ccguccccgc cuucgccucc ucccucaccu ccugcggccc ccgcgcccuc      180

cucacccucc gccccggcgu cucccucacc ggcaccaagc acaaccccuu caucugcacc      240

gccuccuucc acaccuccgc cccccucgcc aaggaggacu acuaccagau ccucggcguc      300

ccccgcaacg ccucccagaa ggagaucaag aaggccuacu accagcucgc caagaaguac      360

caccccgaca ccaacaagga cgaccccaag gccaaggaga aguucuccca gcucgccgag      420

gccuacgagg uccucuccga cgaggucaag cgcaagcagu acgacgccua cggcuccgcc      480

ggcuucgacc ccggcgccuc cggcucccag cacuccuacu ggaagggcgg ccccaccguc      540

gaccccgagg agcucuuccg caagaucuuc ggcgaguucu ccuccuccuc cuucggcgac      600

uuccagaccg ucuucgacca gccccaggag uacuucaugg agcucaccuu caaccaggcc      660

gccaagggcg ucaacaagga guucaccguc aacaucaugg acaccugcga gcgcugcaac      720

ggcaagggca acgagcccgg caccaagguc cagcacugcc acuacugcgg cggcuccggc      780

auggagacca ucaacaccgg ccccuucguc augcgcucca ccugccgccg cugcggcggc      840

cgcggcucca ucaucaucuc ccccugcguc gucugccgcg gcgccggcca ggccaagcag      900

aagaagcgcg ucaugauccc cguccccgcc ggcgucgagg acggccagac cguccgcaug      960

cccgucggca agcgcgagau cuucaucacc uuccgcgucc agaagucccc cgucuuccgc     1020

cgcgacggcg ccgacaucca cuccgaccuc uucaucucca ucgcccaggc ccuccucggc     1080

ggcaccgccc gcgcccaggg ccucuacgag accaucaacg ucaccauccc ccccggcacc     1140

cagaccgacc agaagauccg caugggcggc aagggcaucc cccgcaucaa cuccuacggc     1200

uacggcgacc acuacaucca caucaagauc cgcgucccca agcgccucac cucccgccag     1260

cagucccuca uccucuccua cgccgaggac gagaccgacg ucgagggcac cgucaacggc     1320

gucacccuca ccuccuccgg cggcuccacc auggacuccu ccgccggcuc caaggcccgc     1380

cgcgaggccg gcgaggacga ggagggcuuc cucuccaagc ucaagaagau guucaccucc     1440

uga                                                                   1443


<210>  8336
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJA3__Homo_sapiens__AAC29066

<400>  8336
auggccgcua gaugcagcac cagguggcug cucguggucg uuggcacacc ccggcuuccu       60

gcaaucuccg ggcgcggagc ccgaccaccg cgugagggug ugguaggcgc guggcugucu      120

agaaaguugu cagugcccgc uuucgccagu agcuuaacuu ccugugggcc uagggcacug      180

cuaacgcucc ggccaggagu cucucugacc ggcacaaaac acaaccccuu uauuugcacu      240

gccucguucc auaccucagc uccucuugca aaggaagacu acuaucagau acugggugug      300

ccacgcaaug ccagccaaaa agagaucaag aaggcuuacu aucaguuggc caagaaguac      360

caccccgaua caaacaaaga cgauccuaag gcgaaagaaa aguuuaguca gcucgcagag      420

gccuaugaag uucuguccga cgaggugaaa agaaagcagu acgaugcuua ugggucugcc      480

ggauucgacc caggcgcaag cggcucccaa cauucauacu ggaaaggggg accgaccguc      540

gaucccgagg aacuguuuag gaaaauuuuc ggugaguuua guucuagcuc cuucggcgac      600

uuucagacug uguucgauca gccucaggaa uacuuuaugg agcucacauu caaucaagcu      660

gccaaggggg uaaacaaaga guuuaccguu aauaucaugg acacguguga acggugcaac      720

ggaaagggca augagccagg uacuaaagug cagcacuguc auuauugcgg gggaucaggc      780

auggaaacca uuaacacagg ccccuucguc augcgcagca cuugucgaag augcggggga      840

agggguagua ucauaaucuc uccuugugug gugugccggg gcgcggggca ggccaagcag      900

aaaaagcgug ucaugauucc aguucccgca ggaguggagg auggccaaac cguacgcaug      960

ccggugggua agagagaaau cuucauuaca uuuagggucc agaaaucccc uguguuccgg     1020

cgagacgggg cugauaucca cagcgacuua uuuauaucga uugcccaggc ucugcuuggc     1080

ggaaccgccc gcgcacaagg cuuguacgag acgaucaaug uuacuauucc cccagggaca     1140

cagaccgacc agaagaucag aaugggaggu aaaggcaucc cuaggauuaa cucuuauggg     1200

uacggagauc acuauauaca uaucaagauu cgggugccca aacgccugac uuccagacag     1260

caaucacuaa uccucaguua cgccgaggac gaaacagaug ucgagggcac cgugaauggu     1320

guaacgcuga ccagcuccgg gggcucuaca auggacagcu cagcuggaag uaaggcgagg     1380

cgugaagcag gcgaggauga agagggguuc cuuuccaagc ugaaaaagau guuuacuagc     1440

uga                                                                   1443


<210>  8337
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJA3__Homo_sapiens__AAC29066

<400>  8337
auggccgcca gaugcagcac cagauggcug cugguggugg ugggcacccc cagacugccc       60

gccaucagcg gcagaggcgc cagacccccc agagagggcg uggugggcgc cuggcugagc      120

agaaagcuga gcgugcccgc cuucgccagc agccugacca gcugcggccc cagagcccug      180

cugacccuga gacccggcgu gagccugacc ggcaccaagc acaaccccuu caucugcacc      240

gccagcuucc acaccagcgc cccccuggcc aaggaggacu acuaccagau ccugggcgug      300

cccagaaacg ccagccagaa ggagaucaag aaggccuacu accagcuggc caagaaguac      360

caccccgaca ccaacaagga cgaccccaag gccaaggaga aguucagcca gcuggccgag      420

gccuacgagg ugcugagcga cgaggugaag agaaagcagu acgacgccua cggcagcgcc      480

ggcuucgacc ccggcgccag cggcagccag cacagcuacu ggaagggcgg ccccaccgug      540

gaccccgagg agcuguucag aaagaucuuc ggcgaguuca gcagcagcag cuucggcgac      600

uuccagaccg uguucgacca gccccaggag uacuucaugg agcugaccuu caaccaggcc      660

gccaagggcg ugaacaagga guucaccgug aacaucaugg acaccugcga gagaugcaac      720

ggcaagggca acgagcccgg caccaaggug cagcacugcc acuacugcgg cggcagcggc      780

auggagacca ucaacaccgg ccccuucgug augagaagca ccugcagaag augcggcggc      840

agaggcagca ucaucaucag ccccugcgug gugugcagag gcgccggcca ggccaagcag      900

aagaagagag ugaugauccc cgugcccgcc ggcguggagg acggccagac cgugagaaug      960

cccgugggca agagagagau cuucaucacc uucagagugc agaagagccc cguguucaga     1020

agagacggcg ccgacaucca cagcgaccug uucaucagca ucgcccaggc ccugcugggc     1080

ggcaccgcca gagcccaggg ccuguacgag accaucaacg ugaccauccc ccccggcacc     1140

cagaccgacc agaagaucag aaugggcggc aagggcaucc ccagaaucaa cagcuacggc     1200

uacggcgacc acuacaucca caucaagauc agagugccca agagacugac cagcagacag     1260

cagagccuga uccugagcua cgccgaggac gagaccgacg uggagggcac cgugaacggc     1320

gugacccuga ccagcagcgg cggcagcacc auggacagca gcgccggcag caaggccaga     1380

agagaggccg gcgaggacga ggagggcuuc cugagcaagc ugaagaagau guucaccagc     1440

uga                                                                   1443


<210>  8338
<211>  1443
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJA3__Homo_sapiens__AAC29066

<400>  8338
auggccgcua gaugcagcac ccgguggcug cucguggucg uuggcacacc ccgccugccu       60

gccaucuccg ggagaggagc gcggccgccc cgcgagggcg uggugggggc uuggcuuucu      120

agaaagcuga gcgucccugc cuucgccucc ucucucacga gcuguggacc ccgggcucug      180

cuuacccugc gcccuggcgu gucccucaca gggaccaaac acaaccccuu uauuugcaca      240

gccucuuucc auaccagcgc uccucuggcc aaggaagacu acuaucagau ccugggaguu      300

ccgagaaaug cgucccaaaa agagauuaag aaagccuacu aucagcucgc uaagaaguac      360

caccccgaua caaacaaaga cgauccuaag gccaaagaaa aguuuagcca gcuggcugag      420

gccuaugaag ugcuuucuga cgaggucaaa cggaagcagu acgaugcgua uggcuccgcc      480

ggcuucgacc ccggggcuag cggaucucaa cauuccuacu ggaagggcgg gccuaccgug      540

gaucccgagg aacuguuucg caaaaucuuc ggagaguuuu cuagcuccag cuucggcgac      600

uuucagacgg uuuucgauca gccgcaggaa uacuuuaugg agcucaccuu caaucaagcc      660

gcuaaggggg ugaacaaaga guuuacaguc aauauuaugg acaccuguga aagaugcaac      720

ggaaagggca augagccugg cacaaaagug cagcacuguc auuauugcgg gggauccggc      780

auggaaacca ucaacacggg gcccuucgug augcggucua caugucgcag augcggaggc      840

cgggggagca ucauuaucuc cccuuguguc guuugccgcg gagccggcca ggccaagcag      900

aaaaagagag ugaugauucc cgugcccgcu ggcgucgagg augggcaaac cgugcggaug      960

ccuguuggaa agagagaaau cuucauuaca uuucgcgugc agaaaagccc ggucuuccgg     1020

agagacggcg cggauaucca cucugaccug uuuauuucca ucgcccaggc ucugcuuggg     1080

ggaaccgccc gcgcccaagg ccucuacgag accaucaaug ugacaauucc cccugggacg     1140

cagaccgacc agaagauccg gaugggcgga aaaggcauuc ccagaaucaa cagcuauggg     1200

uacggagauc acuauauuca uaucaagauc cgcguuccua aacggcugac aucuagacag     1260

caaagccuga uucucuccua cgcugaggac gaaaccgaug uggagggcac agucaauggg     1320

gugacccuga cgucuagcgg aggcuccaca auggacagcu cugccggguc caaggcgcgc     1380

cgggaagcug gcgaggauga agagggauuc cuuagcaagc ugaaaaagau guuuaccucu     1440

uga                                                                   1443


<210>  8339
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJA4__Homo_sapiens__Q8WW22

<400>  8339

Met Val Lys Glu Thr Gln Tyr Tyr Asp Ile Leu Gly Val Lys Pro Ser 
1               5                   10                  15      


Ala Ser Pro Glu Glu Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asp Glu Gly Glu Lys Phe Lys Leu Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Asp Val Tyr 
    50                  55                  60                  


Asp Gln Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ser Gly Ser Pro 
65                  70                  75                  80  


Ser Phe Ser Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly 
                85                  90                  95      


Gly Arg Met Ala Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu 
            100                 105                 110         


Ser Val Thr Leu Glu Asp Leu Tyr Asn Gly Val Thr Lys Lys Leu Ala 
        115                 120                 125             


Leu Gln Lys Asn Val Ile Cys Glu Lys Cys Glu Gly Val Gly Gly Lys 
    130                 135                 140                 


Lys Gly Ser Val Glu Lys Cys Pro Leu Cys Lys Gly Arg Gly Met Gln 
145                 150                 155                 160 


Ile His Ile Gln Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Thr 
                165                 170                 175     


Val Cys Ile Glu Cys Lys Gly Gln Gly Glu Arg Ile Asn Pro Lys Asp 
            180                 185                 190         


Arg Cys Glu Ser Cys Ser Gly Ala Lys Val Ile Arg Glu Lys Lys Ile 
        195                 200                 205             


Ile Glu Val His Val Glu Lys Gly Met Lys Asp Gly Gln Lys Ile Leu 
    210                 215                 220                 


Phe His Gly Glu Gly Asp Gln Glu Pro Glu Leu Glu Pro Gly Asp Val 
225                 230                 235                 240 


Ile Ile Val Leu Asp Gln Lys Asp His Ser Val Phe Gln Arg Arg Gly 
                245                 250                 255     


His Asp Leu Ile Met Lys Met Lys Ile Gln Leu Ser Glu Ala Leu Cys 
            260                 265                 270         


Gly Phe Lys Lys Thr Ile Lys Thr Leu Asp Asn Arg Ile Leu Val Ile 
        275                 280                 285             


Thr Ser Lys Ala Gly Glu Val Ile Lys His Gly Asp Leu Arg Cys Val 
    290                 295                 300                 


Arg Asp Glu Gly Met Pro Ile Tyr Lys Ala Pro Leu Glu Lys Gly Ile 
305                 310                 315                 320 


Leu Ile Ile Gln Phe Leu Val Ile Phe Pro Glu Lys His Trp Leu Ser 
                325                 330                 335     


Leu Glu Lys Leu Pro Gln Leu Glu Ala Leu Leu Pro Pro Arg Gln Lys 
            340                 345                 350         


Val Arg Ile Thr Asp Asp Met Asp Gln Val Glu Leu Lys Glu Phe Cys 
        355                 360                 365             


Pro Asn Glu Gln Asn Trp Arg Gln His Arg Glu Ala Tyr Glu Glu Asp 
    370                 375                 380                 


Glu Asp Gly Pro Gln Ala Gly Val Gln Cys Gln Thr Ala 
385                 390                 395         


<210>  8340
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJA4__Homo_sapiens__AAH21720

<400>  8340
auggugaagg agacccagua cuaugacauc cugggcguga agcccagcgc guccccggag       60

gagaucaaga aggccuaucg gaagcuggcg cucaaguacc acccggacaa gaacccggau      120

gagggcgaga aguuuaaacu cauaucccag gcauaugaag ugcuuucaga uccaaagaaa      180

agggauguuu augaccaagg cggagagcag gcaauuaaag aaggaggcuc aggcagcccc      240

agcuucucuu cacccaugga caucuuugac auguucuuug gugguggugg acggauggcu      300

agagagagaa gaggcaagaa uguuguacac caguuaucug uaacucuuga agauuuauau      360

aauggaguca cgaagaaauu ggcccuccag aaaaauguaa uuugugagaa augugaaggu      420

guugguggga agaagggauc gguggagaag ugcccgcugu gcaaggggcg ggggaugcag      480

auccacaucc agcagaucgg gccgggcaug guacagcaga uccagaccgu gugcaucgag      540

ugcaagggcc agggugagcg caucaacccc aaggaccgcu gcgagagcug cagcggggcc      600

aaggugaucc gugagaagaa gauuaucgag guacauguug aaaaagguau gaaagauggg      660

caaaagauac uauuucaugg agaaggagau caggagccug agcuggagcc uggugauguc      720

auaauugugc uugaucagaa ggaucauagu gucuuucaga gacgaggcca ugacuugauc      780

augaaaauga aaauucagcu uucugaagcu cuuuguggcu ucaagaagac gauaaaaaca      840

uuggacaauc gaauucuugu uauuacaucc aaagcaggug aggugauaaa gcacggggac      900

cugagaugcg ugcgcgauga aggaaugccc aucuacaaag caccccugga aaaagggauu      960

cugaucauac aguuuuuagu aaucuuuccu gaaaaacacu ggcuuucucu ggaaaagcuu     1020

ccucagcugg aagcuuuacu cccuccucga cagaaaguga ggauuacaga ugacauggau     1080

cagguggagc ugaaggaguu uugucccaau gagcagaacu ggcgucagca cagggaggcc     1140

uacgaggagg acgaagacgg gccccaggcu ggagugcagu gccagacggc auga           1194


<210>  8341
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJA4__Homo_sapiens__AAH21720

<400>  8341
auggugaagg agacccagua cuacgacauc cugggcguca agcccagcgc cuccccggag       60

gagaucaaga aggccuaccg caagcucgcg cugaaguacc accccgacaa gaaccccgac      120

gagggggaga aguucaagcu gaucagccag gccuacgagg ugcucuccga ccccaagaag      180

cgggacgugu acgaccaggg cggggagcag gccaucaagg agggcgggag cggcuccccg      240

agcuucucca gccccaugga caucuucgac auguucuucg gcgggggcgg gcgcauggcc      300

cgggagcgcc ggggcaagaa cgucgugcac cagcuguccg ugacccugga ggaccucuac      360

aacgggguca cgaagaagcu ggcccugcag aagaacguga ucugcgagaa gugcgagggc      420

gugggcggga agaagggcag cgucgagaag ugcccccucu gcaaggggcg cggcaugcag      480

auccacaucc agcagaucgg ccccgggaug gugcagcaga uccagaccgu gugcaucgag      540

ugcaagggcc agggggagcg gaucaacccg aaggaccgcu gcgaguccug cagcggcgcg      600

aaggucaucc gggagaagaa gaucaucgag gugcacgugg agaaggggau gaaggacggc      660

cagaagaucc uguuccacgg cgagggggac caggagcccg agcuggagcc cggcgacguc      720

aucaucgugc ucgaccagaa ggaccacucc guguuccagc gccgggggca cgaccugauc      780

augaagauga agauccagcu gagcgaggcc cucugcggcu ucaagaagac caucaagacc      840

cuggacaacc gcauccuggu caucacgucc aaggccgggg aggugaucaa gcacggcgac      900

cuccggugcg ugcgcgacga gggcaugccc aucuacaagg ccccgcugga gaaggggauc      960

cugaucaucc aguuccucgu caucuucccc gagaagcacu ggcugagccu ggagaagcuc     1020

ccccagcugg aggcgcugcu gcccccgcgg cagaaggugc gcaucaccga cgacauggac     1080

cagguggagc ucaaggaguu cugccccaac gagcagaacu ggcggcagca ccgcgaggcc     1140

uacgaggagg acgaggacgg cccccaggcc gggguccagu gccagaccgc cuga           1194


<210>  8342
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJA4__Homo_sapiens__AAH21720

<400>  8342
auggucaagg agacccagua cuacgacauc cucggcguca agcccuccgc cucccccgag       60

gagaucaaga aggccuaccg caagcucgcc cucaaguacc accccgacaa gaaccccgac      120

gagggcgaga aguucaagcu caucucccag gccuacgagg uccucuccga ccccaagaag      180

cgcgacgucu acgaccaggg cggcgagcag gccaucaagg agggcggcuc cggcuccccc      240

uccuucuccu cccccaugga caucuucgac auguucuucg gcggcggcgg ccgcauggcc      300

cgcgagcgcc gcggcaagaa cgucguccac cagcucuccg ucacccucga ggaccucuac      360

aacggcguca ccaagaagcu cgcccuccag aagaacguca ucugcgagaa gugcgagggc      420

gucggcggca agaagggcuc cgucgagaag ugcccccucu gcaagggccg cggcaugcag      480

auccacaucc agcagaucgg ccccggcaug guccagcaga uccagaccgu cugcaucgag      540

ugcaagggcc agggcgagcg caucaacccc aaggaccgcu gcgaguccug cuccggcgcc      600

aaggucaucc gcgagaagaa gaucaucgag guccacgucg agaagggcau gaaggacggc      660

cagaagaucc ucuuccacgg cgagggcgac caggagcccg agcucgagcc cggcgacguc      720

aucaucgucc ucgaccagaa ggaccacucc gucuuccagc gccgcggcca cgaccucauc      780

augaagauga agauccagcu cuccgaggcc cucugcggcu ucaagaagac caucaagacc      840

cucgacaacc gcauccucgu caucaccucc aaggccggcg aggucaucaa gcacggcgac      900

cuccgcugcg uccgcgacga gggcaugccc aucuacaagg ccccccucga gaagggcauc      960

cucaucaucc aguuccucgu caucuucccc gagaagcacu ggcucucccu cgagaagcuc     1020

ccccagcucg aggcccuccu ccccccccgc cagaaggucc gcaucaccga cgacauggac     1080

caggucgagc ucaaggaguu cugccccaac gagcagaacu ggcgccagca ccgcgaggcc     1140

uacgaggagg acgaggacgg cccccaggcc ggcguccagu gccagaccgc cuga           1194


<210>  8343
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJA4__Homo_sapiens__AAH21720

<400>  8343
auggugaagg agacccagua cuaugacauc cugggcguca aacccagcgc cuccccugaa       60

gagauuaaga aggcuuacag aaaacucgca cuuaaauauc acccagauaa gaacccggac      120

gaaggggaga aguucaaacu gauaucucaa gccuacgaag uuuugucaga ucccaagaaa      180

agggacgugu augaucaggg aggugagcag gcgaucaagg agggcgggag uggaagcccu      240

uccuuuucuu cgccaaugga cauuuucgau auguuuuucg gcgguggggg acggauggcu      300

cgcgaacgac guggcaaaaa uguagugcau caguuaucag ucacacugga ggaccuauac      360

aacggcguga cuaagaagcu cgcccugcag aaaaauguua ucugcgaaaa gugugagggg      420

gugggaggua aaaagggcag cgucgagaaa ugcccccuuu guaaggggag aggaaugcaa      480

auucacaucc agcagauagg cccugguaug gugcaacaga uccagacggu augcauugaa      540

uguaaagggc agggagagag gaucaaccca aaggaucggu gcgaaaguug uuccggcgca      600

aagguuauuc gcgagaaaaa gaucauagaa gugcaugucg agaaaggcau gaaggacggg      660

cagaaaauuc uguuucacgg agagggugau caagaacccg aguuggaacc uggcgacgug      720

aucauugugc ucgaucagaa ggaccauucu gucuuccaaa gaagggggca cgaccugauc      780

augaagauga aaauccagcu gagcgaggcc cucugcggau uuaagaaaac cauuaagaca      840

uuagauaauc ggauacuggu uaucacuucc aaagcuggcg aagugauuaa gcacggugac      900

cuucgcugug uacgagauga ggggaugcca aucuauaagg caccguugga gaaaggcaua      960

cugauuaucc aguuccuagu gaucuuuccc gaaaagcauu ggcucucacu ggagaaacuu     1020

ccucagcugg aagccuugcu cccacccaga caaaagguca ggauuaccga cgauauggac     1080

cagguggagc ugaaagaguu cugcccuaac gaacagaauu ggcggcagca ccgugaggcu     1140

uacgaagagg augaagacgg accacaagcc ggcguucagu gucagacagc guga           1194


<210>  8344
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJA4__Homo_sapiens__AAH21720

<400>  8344
auggugaagg agacccagua cuacgacauc cugggcguga agcccagcgc cagccccgag       60

gagaucaaga aggccuacag aaagcuggcc cugaaguacc accccgacaa gaaccccgac      120

gagggcgaga aguucaagcu gaucagccag gccuacgagg ugcugagcga ccccaagaag      180

agagacgugu acgaccaggg cggcgagcag gccaucaagg agggcggcag cggcagcccc      240

agcuucagca gccccaugga caucuucgac auguucuucg gcggcggcgg cagaauggcc      300

agagagagaa gaggcaagaa cguggugcac cagcugagcg ugacccugga ggaccuguac      360

aacggcguga ccaagaagcu ggcccugcag aagaacguga ucugcgagaa gugcgagggc      420

gugggcggca agaagggcag cguggagaag ugcccccugu gcaagggcag aggcaugcag      480

auccacaucc agcagaucgg ccccggcaug gugcagcaga uccagaccgu gugcaucgag      540

ugcaagggcc agggcgagag aaucaacccc aaggacagau gcgagagcug cagcggcgcc      600

aaggugauca gagagaagaa gaucaucgag gugcacgugg agaagggcau gaaggacggc      660

cagaagaucc uguuccacgg cgagggcgac caggagcccg agcuggagcc cggcgacgug      720

aucaucgugc uggaccagaa ggaccacagc guguuccaga gaagaggcca cgaccugauc      780

augaagauga agauccagcu gagcgaggcc cugugcggcu ucaagaagac caucaagacc      840

cuggacaaca gaauccuggu gaucaccagc aaggccggcg aggugaucaa gcacggcgac      900

cugagaugcg ugagagacga gggcaugccc aucuacaagg ccccccugga gaagggcauc      960

cugaucaucc aguuccuggu gaucuucccc gagaagcacu ggcugagccu ggagaagcug     1020

ccccagcugg aggcccugcu gccccccaga cagaagguga gaaucaccga cgacauggac     1080

cagguggagc ugaaggaguu cugccccaac gagcagaacu ggagacagca cagagaggcc     1140

uacgaggagg acgaggacgg cccccaggcc ggcgugcagu gccagaccgc cuga           1194


<210>  8345
<211>  1194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJA4__Homo_sapiens__AAH21720

<400>  8345
auggugaagg agacccagua cuaugacauc cugggcguca aacccagcgc cuccccugaa       60

gagauuaaga aggcuuacag aaaacucgcc cugaaauauc acccggauaa gaaccccgac      120

gaaggggaga aguucaaacu uaucucucaa gcguacgaag uucugagcga uccuaagaaa      180

cgggacgugu augaucaggg aggcgagcag gcuauuaagg aagggggauc cggcucuccc      240

agcuuuuccu cuccuaugga caucuucgau auguuuuucg ggggaggcgg ccgcauggcc      300

agagaacggc gcgggaaaaa ugugguccau cagcucagcg ugacacugga ggaccuuuac      360

aacggaguua cgaagaagcu ggcccuccag aaaaauguga uuugcgaaaa gugugagggc      420

gucgggggca aaaagggauc cguggagaaa ugcccccugu guaaggggag aggaaugcaa      480

auccacaucc agcagauugg cccuggcaug guucaacaga uccagaccgu gugcauugaa      540

uguaaagggc agggagagcg gaucaacccg aaggaucgcu gcgaaagcug uucuggcgcu      600

aaggucauua gagagaaaaa gaucauugaa gugcaugugg agaaagggau gaaggacgga      660

cagaaaaucc uguuucacgg cgagggggau caagaacccg agcucgaacc uggagacguc      720

aucauuguuc uggaucagaa ggaccauucc guguuccaac ggcgcggcca cgaccuuauc      780

augaagauga aaauucagcu gagcgaggcc cucugcggcu uuaagaaaac aaucaagacc      840

cuggauaauc ggauucuugu gaucacaucu aaagcugggg aagucaucaa gcacggagac      900

cugagaugug ugcgcgauga gggcaugccc auuuauaagg ccccucucga gaaagggauc      960

cugauuaucc aguuccuggu uauuuuuccc gaaaagcauu ggcucucccu ggagaaacuu     1020

ccgcagcugg aagcgcuccu gccucccaga caaaaggugc ggaucaccga cgauauggac     1080

caggucgagc uuaaagaguu cugcccuaac gagcagaauu ggcgccagca cagagaggcc     1140

uacgaagagg augaagacgg accccaagcu ggcgugcagu gucagacagc cuga           1194


<210>  8346
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB1__Homo_sapiens__P25685

<400>  8346

Met Gly Lys Asp Tyr Tyr Gln Thr Leu Gly Leu Ala Arg Gly Ala Ser 
1               5                   10                  15      


Asp Glu Glu Ile Lys Arg Ala Tyr Arg Arg Gln Ala Leu Arg Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Gly Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Arg Lys Arg Glu Ile Phe 
    50                  55                  60                  


Asp Arg Tyr Gly Glu Glu Gly Leu Lys Gly Ser Gly Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Ala Asn Gly Thr Ser Phe Ser Tyr Thr Phe His Gly 
                85                  90                  95      


Asp Pro His Ala Met Phe Ala Glu Phe Phe Gly Gly Arg Asn Pro Phe 
            100                 105                 110         


Asp Thr Phe Phe Gly Gln Arg Asn Gly Glu Glu Gly Met Asp Ile Asp 
        115                 120                 125             


Asp Pro Phe Ser Gly Phe Pro Met Gly Met Gly Gly Phe Thr Asn Val 
    130                 135                 140                 


Asn Phe Gly Arg Ser Arg Ser Ala Gln Glu Pro Ala Arg Lys Lys Gln 
145                 150                 155                 160 


Asp Pro Pro Val Thr His Asp Leu Arg Val Ser Leu Glu Glu Ile Tyr 
                165                 170                 175     


Ser Gly Cys Thr Lys Lys Met Lys Ile Ser His Lys Arg Leu Asn Pro 
            180                 185                 190         


Asp Gly Lys Ser Ile Arg Asn Glu Asp Lys Ile Leu Thr Ile Glu Val 
        195                 200                 205             


Lys Lys Gly Trp Lys Glu Gly Thr Lys Ile Thr Phe Pro Lys Glu Gly 
    210                 215                 220                 


Asp Gln Thr Ser Asn Asn Ile Pro Ala Asp Ile Val Phe Val Leu Lys 
225                 230                 235                 240 


Asp Lys Pro His Asn Ile Phe Lys Arg Asp Gly Ser Asp Val Ile Tyr 
                245                 250                 255     


Pro Ala Arg Ile Ser Leu Arg Glu Ala Leu Cys Gly Cys Thr Val Asn 
            260                 265                 270         


Val Pro Thr Leu Asp Gly Arg Thr Ile Pro Val Val Phe Lys Asp Val 
        275                 280                 285             


Ile Arg Pro Gly Met Arg Arg Lys Val Pro Gly Glu Gly Leu Pro Leu 
    290                 295                 300                 


Pro Lys Thr Pro Glu Lys Arg Gly Asp Leu Ile Ile Glu Phe Glu Val 
305                 310                 315                 320 


Ile Phe Pro Glu Arg Ile Pro Gln Thr Ser Arg Thr Val Leu Glu Gln 
                325                 330                 335     


Val Leu Pro Ile 
            340 


<210>  8347
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB1__Homo_sapiens__AAH02352

<400>  8347
auggguaaag acuacuacca gacguugggc cuggcccgcg gcgcgucgga cgaggagauc       60

aagcgggccu accgccgcca ggcgcugcgc uaccacccgg acaagaacaa ggagcccggc      120

gccgaggaga aguucaagga gaucgcugag gccuacgacg ugcucagcga cccgcgcaag      180

cgcgagaucu ucgaccgcua cggggaggaa ggccuaaagg ggaguggccc caguggcggu      240

agcggcggug gugccaaugg uaccucuuuc agcuacacau uccauggaga cccucaugcc      300

auguuugcug aguucuucgg uggcagaaau cccuuugaca ccuuuuuugg gcagcggaac      360

ggggaggaag gcauggacau ugaugaccca uucucuggcu ucccuauggg cauggguggc      420

uucaccaacg ugaacuuugg ccgcucccgc ucugcccaag agcccgcccg aaagaagcaa      480

gaucccccag ucacccacga ccuucgaguc ucccuugaag agaucuacag cggcuguacc      540

aagaagauga aaaucuccca caagcggcua aaccccgacg gaaagagcau ucgaaacgaa      600

gacaaaauau ugaccaucga agugaagaag ggguggaaag aaggaaccaa aaucacuuuc      660

cccaaggaag gagaccagac cuccaacaac auuccagcug auaucgucuu uguuuuaaag      720

gacaagcccc acaauaucuu uaagagagau ggcucugaug ucauuuaucc ugccaggauc      780

agccuccggg aggcucugug uggcugcaca gugaacgucc ccacucugga cggcaggacg      840

auacccgucg uauucaaaga uguuaucagg ccuggcaugc ggcgaaaagu uccuggagaa      900

ggccuccccc uccccaaaac acccgagaaa cguggggacc ucauuauuga guuugaagug      960

aucuuccccg aaaggauucc ccagacauca agaaccguac uugagcaggu ucuuccaaua     1020

uag                                                                   1023


<210>  8348
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB1__Homo_sapiens__AAH02352

<400>  8348
augggcaagg acuacuacca gacccugggg cucgcccgcg gcgccagcga cgaggagauc       60

aagcgggcgu accgccggca ggcccugcgc uaccaccccg acaagaacaa ggagccgggg      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg ugcuguccga cccccggaag      180

cgcgagaucu ucgaccggua cggcgaggag gggcucaagg gcagcggccc cuccgggggc      240

agcgggggcg gggcgaacgg caccuccuuc agcuacacgu uccacggcga cccccacgcc      300

auguucgccg aguucuucgg gggccgcaac ccguucgaca ccuucuucgg gcagcggaac      360

ggcgaggagg gcauggacau cgacgacccc uucuccgggu uccccauggg caugggcggg      420

uucaccaacg ucaacuucgg gcgcagccgg uccgcccagg agcccgcgcg caagaagcag      480

gacccgcccg ugacccacga ccugcgggug agccuggagg agaucuacuc cggcugcacg      540

aagaagauga agaucagcca caagcgccuc aaccccgacg gcaaguccau ccggaacgag      600

gacaagaucc ugaccaucga ggucaagaag ggguggaagg agggcaccaa gaucaccuuc      660

cccaaggagg gggaccagac gagcaacaac aucccggccg acaucguguu cgugcugaag      720

gacaagcccc acaacaucuu caagcgcgac ggcuccgacg ucaucuaccc cgcccggauc      780

agccuccgcg aggcccugug cgggugcacc gugaacgugc ccacccugga cggccggacc      840

aucccggucg uguucaagga cgugauccgc cccggcaugc ggcgcaaggu ccccggggag      900

ggccuccccc ugccgaagac gcccgagaag cgcggggacc ugaucaucga guucgaggug      960

aucuuccccg agcggauccc ccagaccucc cgcaccgugc ucgagcaggu ccugccgauc     1020

uga                                                                   1023


<210>  8349
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB1__Homo_sapiens__AAH02352

<400>  8349
augggcaagg acuacuacca gacccucggc cucgcccgcg gcgccuccga cgaggagauc       60

aagcgcgccu accgccgcca ggcccuccgc uaccaccccg acaagaacaa ggagcccggc      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg uccucuccga cccccgcaag      180

cgcgagaucu ucgaccgcua cggcgaggag ggccucaagg gcuccggccc cuccggcggc      240

uccggcggcg gcgccaacgg caccuccuuc uccuacaccu uccacggcga cccccacgcc      300

auguucgccg aguucuucgg cggccgcaac cccuucgaca ccuucuucgg ccagcgcaac      360

ggcgaggagg gcauggacau cgacgacccc uucuccggcu uccccauggg caugggcggc      420

uucaccaacg ucaacuucgg ccgcucccgc uccgcccagg agcccgcccg caagaagcag      480

gacccccccg ucacccacga ccuccgcguc ucccucgagg agaucuacuc cggcugcacc      540

aagaagauga agaucuccca caagcgccuc aaccccgacg gcaaguccau ccgcaacgag      600

gacaagaucc ucaccaucga ggucaagaag ggcuggaagg agggcaccaa gaucaccuuc      660

cccaaggagg gcgaccagac cuccaacaac auccccgccg acaucgucuu cguccucaag      720

gacaagcccc acaacaucuu caagcgcgac ggcuccgacg ucaucuaccc cgcccgcauc      780

ucccuccgcg aggcccucug cggcugcacc gucaacgucc ccacccucga cggccgcacc      840

auccccgucg ucuucaagga cgucauccgc cccggcaugc gccgcaaggu ccccggcgag      900

ggccuccccc uccccaagac ccccgagaag cgcggcgacc ucaucaucga guucgagguc      960

aucuuccccg agcgcauccc ccagaccucc cgcaccgucc ucgagcaggu ccuccccauc     1020

uga                                                                   1023


<210>  8350
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB1__Homo_sapiens__AAH02352

<400>  8350
augggcaagg acuacuauca gacccugggg cucgccagag gagcuagcga ugaggagauc       60

aaaagggcau accggcgcca agcccuucga uaucaccccg acaagaacaa agagccuggu      120

gcggaagaga aguucaaaga aauugcugag gccuacgaug ugcuguccga cccacguaag      180

agagagauau uugauaggua uggcgaagag ggguugaagg gaucuggccc gucagguggg      240

aguggaggcg gcgcaaaugg gacuagcuuc uccuacacau uucauggaga cccccacgcc      300

auguucgcug aauuuuucgg uggccggaac ccuuuugaua cguucuuugg gcagcgcaau      360

ggagaggagg gcauggacau cgaugaccca uucucugguu uucccauggg gaugggaggc      420

uucaccaacg ucaauuuugg cagaucgagg ucagcacagg aaccugcccg gaaaaagcag      480

gauccacccg uuacacauga cuuacgcgug agccuggagg aaauuuauag ugggugcacu      540

aaaaagauga aaaucuccca caagcgacua aacccugaug gaaagucuau uagaaaugag      600

gacaaaaucc ucaccauaga aguaaagaaa gguuggaagg agggcacaaa aaucaccuuc      660

ccaaaggagg gggaccaaac uagcaacaau auuccggcug auaucguguu cguccugaaa      720

gacaagcccc auaacauuuu uaagagggau ggauccgacg ugaucuaccc ugcccggaua      780

ucacuucgug aagcgcugug uggcugcaca guuaaugugc caaccuugga uggucgcacg      840

auucccgucg uguucaaaga cguaaucaga ccugggauga ggcggaaggu uccaggcgag      900

ggacuccccc ugccgaaaac uccugaaaag cgaggcgauc ugauuaucga guuugaagug      960

aucuuccccg agcgcauucc acagaccagu agaacagucc ucgaacaggu guuaccuaua     1020

uga                                                                   1023


<210>  8351
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB1__Homo_sapiens__AAH02352

<400>  8351
augggcaagg acuacuacca gacccugggc cuggccagag gcgccagcga cgaggagauc       60

aagagagccu acagaagaca ggcccugaga uaccaccccg acaagaacaa ggagcccggc      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg ugcugagcga ccccagaaag      180

agagagaucu ucgacagaua cggcgaggag ggccugaagg gcagcggccc cagcggcggc      240

agcggcggcg gcgccaacgg caccagcuuc agcuacaccu uccacggcga cccccacgcc      300

auguucgccg aguucuucgg cggcagaaac cccuucgaca ccuucuucgg ccagagaaac      360

ggcgaggagg gcauggacau cgacgacccc uucagcggcu uccccauggg caugggcggc      420

uucaccaacg ugaacuucgg cagaagcaga agcgcccagg agcccgccag aaagaagcag      480

gacccccccg ugacccacga ccugagagug agccuggagg agaucuacag cggcugcacc      540

aagaagauga agaucagcca caagagacug aaccccgacg gcaagagcau cagaaacgag      600

gacaagaucc ugaccaucga ggugaagaag ggcuggaagg agggcaccaa gaucaccuuc      660

cccaaggagg gcgaccagac cagcaacaac auccccgccg acaucguguu cgugcugaag      720

gacaagcccc acaacaucuu caagagagac ggcagcgacg ugaucuaccc cgccagaauc      780

agccugagag aggcccugug cggcugcacc gugaacgugc ccacccugga cggcagaacc      840

auccccgugg uguucaagga cgugaucaga cccggcauga gaagaaaggu gcccggcgag      900

ggccugcccc ugcccaagac ccccgagaag agaggcgacc ugaucaucga guucgaggug      960

aucuuccccg agagaauccc ccagaccagc agaaccgugc uggagcaggu gcugcccauc     1020

uga                                                                   1023


<210>  8352
<211>  1023
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB1__Homo_sapiens__AAH02352

<400>  8352
augggcaagg acuacuauca gacccugggg cucgccagag gagcuagcga ugaggaaauc       60

aaacgggccu accgcagaca agcgcugcgg uaucaccccg acaagaacaa agagccuggc      120

gcugaagaga aguucaaaga aauugccgag gccuacgaug ugcuuuccga cccgcgcaag      180

agagagaucu uugaucggua uggggaagag ggacugaagg gcucugggcc cagcggaggc      240

uccggcgggg gagcuaaugg cacaucuuuc agcuacacgu uucaugggga cccucacgcc      300

auguucgcug aauuuuucgg aggccgcaac cccuuugaua ccuucuuugg gcagagaaau      360

ggagaggagg gcauggacau ugaugacccu uucuccggcu uucccauggg gaugggaggc      420

uucacaaacg ucaauuuugg gcggucucgc agcgcccagg aaccugcgcg gaaaaagcag      480

gauccgcccg uuacccauga ccucagagug ucccuggagg aaaucuauag cggaugcacc      540

aaaaagauga aaauuucuca caagcgccuu aacccugaug gcaaguccau cagaaaugag      600

gacaaaaucc ugacaauuga agugaagaaa ggguggaagg agggaacaaa aaucaccuuc      660

cccaaggagg gcgaccaaac gagcaacaau auuccugccg auaucgucuu cgugcucaaa      720

gacaagcccc auaacauuuu uaagcgggau ggcucugacg uuaucuaccc ggcucgcauu      780

ucccugagag aagcccugug ugggugcacc gugaaugucc cuacacucga uggacggacc      840

auccccgugg uuuucaaaga cgugaucaga ccuggcaugc gccggaaggu ccccggggag      900

ggacugcccc uuccuaaaac accggaaaag agaggcgauc ugauuaucga guuugaagug      960

auuuuccccg agcgcauccc ucagaccagc cggacggugc ucgagcaggu ccugcccauu     1020

uga                                                                   1023


<210>  8353
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB2__Homo_sapiens__P25686

<400>  8353

Met Ala Ser Tyr Tyr Glu Ile Leu Asp Val Pro Arg Ser Ala Ser Ala 
1               5                   10                  15      


Asp Asp Ile Lys Lys Ala Tyr Arg Arg Lys Ala Leu Gln Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Asp Asn Lys Glu Phe Ala Glu Lys Lys Phe Lys Glu 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Lys His Lys Arg Glu Ile 
    50                  55                  60                  


Tyr Asp Arg Tyr Gly Arg Glu Gly Leu Thr Gly Thr Gly Thr Gly Pro 
65                  70                  75                  80  


Ser Arg Ala Glu Ala Gly Ser Gly Gly Pro Gly Phe Thr Phe Thr Phe 
                85                  90                  95      


Arg Ser Pro Glu Glu Val Phe Arg Glu Phe Phe Gly Ser Gly Asp Pro 
            100                 105                 110         


Phe Ala Glu Leu Phe Asp Asp Leu Gly Pro Phe Ser Glu Leu Gln Asn 
        115                 120                 125             


Arg Gly Ser Arg His Ser Gly Pro Phe Phe Thr Phe Ser Ser Ser Phe 
    130                 135                 140                 


Pro Gly His Ser Asp Phe Ser Ser Ser Ser Phe Ser Phe Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ala Phe Arg Ser Val Ser Thr Ser Thr Thr Phe Val Gln Gly 
                165                 170                 175     


Arg Arg Ile Thr Thr Arg Arg Ile Met Glu Asn Gly Gln Glu Arg Val 
            180                 185                 190         


Glu Val Glu Glu Asp Gly Gln Leu Lys Ser Val Thr Ile Asn Gly Val 
        195                 200                 205             


Pro Asp Asp Leu Ala Leu Gly Leu Glu Leu Ser Arg Arg Glu Gln Gln 
    210                 215                 220                 


Pro Ser Val Thr Ser Arg Ser Gly Gly Thr Gln Val Gln Gln Thr Pro 
225                 230                 235                 240 


Ala Ser Cys Pro Leu Asp Ser Asp Leu Ser Glu Asp Glu Asp Leu Gln 
                245                 250                 255     


Leu Ala Met Ala Tyr Ser Leu Ser Glu Met Glu Ala Ala Gly Lys Lys 
            260                 265                 270         


Pro Ala Gly Gly Arg Glu Ala Gln His Arg Arg Gln Gly Arg Pro Lys 
        275                 280                 285             


Ala Gln His Gln Asp Pro Gly Leu Gly Gly Thr Gln Glu Gly Ala Arg 
    290                 295                 300                 


Gly Glu Ala Thr Lys Arg Ser Pro Ser Pro Glu Glu Lys Ala Ser Arg 
305                 310                 315                 320 


Cys Leu Ile Leu 
                


<210>  8354
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB2__Homo_sapiens__AAH11609

<400>  8354
auggcauccu acuacgagau ccuagacgug ccgcgaagug cguccgcuga ugacaucaag       60

aaggcguauc ggcgcaaggc ucuccagugg cacccagaca aaaacccaga uaauaaagag      120

uuugcugaga agaaauuuaa ggagguggcc gaggcauaug aagugcuguc ugacaagcac      180

aagcgggaga uuuacgaccg cuauggccgg gaagggcuga cagggacagg aacuggccca      240

ucucgggcag aagcuggcag uggugggccu ggcuucaccu ucaccuuccg cagccccgag      300

gaggucuucc gggaauucuu ugggagugga gacccuuuug cagagcucuu ugaugaccug      360

ggccccuucu cagagcuuca gaaccggggu ucccgacacu caggccccuu cuuuaccuuc      420

ucuuccuccu ucccugggca cuccgauuuc uccuccucau cuuucuccuu caguccuggg      480

gcuggugcuu uucgcucugu uucuacaucu accaccuuug uccaaggacg ccgcaucacc      540

acacgcagaa ucauggagaa cgggcaggag cggguggaag uggaggagga ugggcagcug      600

aagucaguca caaucaaugg ugucccagau gaccuggcac ugggcuugga gcugagccgu      660

cgcgagcagc agccgucagu cacuuccagg ucugggggca cucaggucca gcagaccccu      720

gccucaugcc ccuuggacag cgaccucucu gaggaugagg accugcagcu ggccauggcc      780

uacagccugu cagagaugga ggcagcuggg aagaaacccg caggugggcg ggaggcacag      840

caccgacggc aggggcggcc caaggcccag caccaagauc caggcuuggg ggggacccag      900

gagggugcga ggggugaagc aaccaaacgc aguccauccc cagaggagaa ggccucucgc      960

ugccucaucc ucuga                                                       975


<210>  8355
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB2__Homo_sapiens__AAH11609

<400>  8355
auggccagcu acuacgagau ccuggacgug ccccgcuccg ccagcgcgga cgacaucaag       60

aaggccuacc ggcgcaaggc ccuccagugg cacccggaca agaaccccga caacaaggag      120

uucgccgaga agaaguucaa ggaggucgcc gaggcguacg aggugcuguc cgacaagcac      180

aagcgggaga ucuacgaccg cuacggccgg gaggggcuga ccggcaccgg gacgggcccc      240

agccgcgccg aggccggguc cggcggcccc ggguucaccu ucaccuuccg gagcccggag      300

gagguguucc gcgaguucuu cggcuccggg gaccccuucg ccgagcuguu cgacgaccug      360

ggccccuuca gcgagcugca gaaccggggg ucccgccaca gcggccccuu cuucaccuuc      420

uccagcuccu ucccgggcca cagcgacuuc uccagcucca gcuucuccuu cagccccggg      480

gcgggcgccu uccggagcgu cuccacgagc accaccuucg ugcaggggcg ccggaucacc      540

acgcgccgga ucauggagaa cggccaggag cgcguggagg ucgaggagga cggccagcuc      600

aaguccguga ccaucaacgg ggugcccgac gaccuggccc ugggccucga gcugagccgg      660

cgcgagcagc agcccuccgu caccagccgg uccgggggca cccaggugca gcagacgccg      720

gccagcugcc cccuggacuc cgaccucagc gaggacgagg accugcagcu ggccauggcg      780

uacucccuca gcgagaugga ggccgccggg aagaagcccg ccggcggccg cgaggcccag      840

caccggcgcc aggggcgccc caaggcgcag caccaggacc cgggccucgg gggcacccag      900

gagggggccc ggggcgaggc caccaagcgc ucccccagcc ccgaggagaa ggccucccgg      960

ugccugaucc ucuga                                                       975


<210>  8356
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB2__Homo_sapiens__AAH11609

<400>  8356
auggccuccu acuacgagau ccucgacguc ccccgcuccg ccuccgccga cgacaucaag       60

aaggccuacc gccgcaaggc ccuccagugg caccccgaca agaaccccga caacaaggag      120

uucgccgaga agaaguucaa ggaggucgcc gaggccuacg agguccucuc cgacaagcac      180

aagcgcgaga ucuacgaccg cuacggccgc gagggccuca ccggcaccgg caccggcccc      240

ucccgcgccg aggccggcuc cggcggcccc ggcuucaccu ucaccuuccg cucccccgag      300

gaggucuucc gcgaguucuu cggcuccggc gaccccuucg ccgagcucuu cgacgaccuc      360

ggccccuucu ccgagcucca gaaccgcggc ucccgccacu ccggccccuu cuucaccuuc      420

uccuccuccu uccccggcca cuccgacuuc uccuccuccu ccuucuccuu cucccccggc      480

gccggcgccu uccgcuccgu cuccaccucc accaccuucg uccagggccg ccgcaucacc      540

acccgccgca ucauggagaa cggccaggag cgcgucgagg ucgaggagga cggccagcuc      600

aaguccguca ccaucaacgg cguccccgac gaccucgccc ucggccucga gcucucccgc      660

cgcgagcagc agcccuccgu caccucccgc uccggcggca cccaggucca gcagaccccc      720

gccuccugcc cccucgacuc cgaccucucc gaggacgagg accuccagcu cgccauggcc      780

uacucccucu ccgagaugga ggccgccggc aagaagcccg ccggcggccg cgaggcccag      840

caccgccgcc agggccgccc caaggcccag caccaggacc ccggccucgg cggcacccag      900

gagggcgccc gcggcgaggc caccaagcgc ucccccuccc ccgaggagaa ggccucccgc      960

ugccucaucc ucuga                                                       975


<210>  8357
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB2__Homo_sapiens__AAH11609

<400>  8357
auggccagcu acuaugagau ccuggacgug cccagauccg cuucugcaga ugacauuaag       60

aaagccuaca ggcggaaggc gcuccagugg cacccugaua aaaacccaga caauaaggaa      120

uuugcugaga aaaaguuuaa ggaagucgcc gaggcauaug aaguucuuuc agauaaacau      180

aagcgcgaga uauacgaccg auauggccgu gaggggcuga ccggaacagg uacuggcccg      240

aguagagccg aagcugggag cggaggcccc gguuucacgu uuaccuucag guccccugag      300

gaaguguuuc gggaguucuu ugggucugga gauccauucg cagaguuguu ugacgauuua      360

ggccccuucu cggaacugca aaaccgcggc ucaagacaca gcgggccuuu cuucacauuu      420

aguuccucuu ucccaggaca uagcgacuuc uccucaagua gcuuuucuuu cucccccggu      480

gccggcgcuu uuaggucagu aagcacgagu accacauucg ugcaggggcg gcgcaucacc      540

acucgaagaa uuauggagaa uggacaggaa agggucgagg uggaagagga uggccagcua      600

aaaucuguua caaucaacgg ugugccugac gaucucgccc uggggcuuga gcugucccgg      660

cgugaacaac agccaagcgu caccucgcgc ucuggaggca cucaggugca gcaaacuccg      720

gcguccugcc ccuuggacuc agaccucagu gaggaugaag accugcagcu ggcaauggcc      780

uacagccucu ccgagaugga agcugccggc aagaaaccug cagggggaag agaggcucag      840

cacaggcggc agggucgacc aaaggcccaa caucaggauc ccggcuuagg gggaacccag      900

gagggcgcgc gcggugaagc cacaaagaga ucuccuagcc cagaggaaaa agcaucaagg      960

ugucugauuc uuuga                                                       975


<210>  8358
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB2__Homo_sapiens__AAH11609

<400>  8358
auggccagcu acuacgagau ccuggacgug cccagaagcg ccagcgccga cgacaucaag       60

aaggccuaca gaagaaaggc ccugcagugg caccccgaca agaaccccga caacaaggag      120

uucgccgaga agaaguucaa ggagguggcc gaggccuacg aggugcugag cgacaagcac      180

aagagagaga ucuacgacag auacggcaga gagggccuga ccggcaccgg caccggcccc      240

agcagagccg aggccggcag cggcggcccc ggcuucaccu ucaccuucag aagccccgag      300

gagguguuca gagaguucuu cggcagcggc gaccccuucg ccgagcuguu cgacgaccug      360

ggccccuuca gcgagcugca gaacagaggc agcagacaca gcggccccuu cuucaccuuc      420

agcagcagcu uccccggcca cagcgacuuc agcagcagca gcuucagcuu cagccccggc      480

gccggcgccu ucagaagcgu gagcaccagc accaccuucg ugcagggcag aagaaucacc      540

accagaagaa ucauggagaa cggccaggag agaguggagg uggaggagga cggccagcug      600

aagagcguga ccaucaacgg cgugcccgac gaccuggccc ugggccugga gcugagcaga      660

agagagcagc agcccagcgu gaccagcaga agcggcggca cccaggugca gcagaccccc      720

gccagcugcc cccuggacag cgaccugagc gaggacgagg accugcagcu ggccauggcc      780

uacagccuga gcgagaugga ggccgccggc aagaagcccg ccggcggcag agaggcccag      840

cacagaagac agggcagacc caaggcccag caccaggacc ccggccuggg cggcacccag      900

gagggcgcca gaggcgaggc caccaagaga agccccagcc ccgaggagaa ggccagcaga      960

ugccugaucc uguga                                                       975


<210>  8359
<211>  975
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB2__Homo_sapiens__AAH11609

<400>  8359
auggccagcu acuaugagau ccuggacgug cccagauccg cuucugccga ugacauuaag       60

aaagcguacc ggcgcaaggc ucuccagugg cacccugaua aaaacccgga caauaaggaa      120

uuugccgaga aaaaguuuaa ggaagucgcc gaggcuuaug aaguucugag cgauaaacau      180

aagagagaga ucuacgaccg guauggccgc gaggggcuua ccggaacagg cacggggccc      240

uccagagccg aagcuggauc uggcgggccu ggauucaccu uuacauuccg gagccccgag      300

gaaguguuuc gcgaguucuu uggcuccggc gauccuuucg ccgagcuguu ugacgaucuc      360

gggcccuucu cugaacugca aaacagagga agccggcacu ccggcccuuu cuucaccuuu      420

ucuucuuccu ucccggggca uagcgacuuc ucuuccagcu cuuuuuccuu cagccccgga      480

gcgggcgccu uucgcuccgu gucuacaagc accacauucg uccaggggag acggauuacc      540

acgcgcagaa ucauggagaa uggacaggaa cggguggagg uugaagagga uggccagcuu      600

aaauccguga ccauuaacgg cgucccugac gaucuggcuc ucgggcugga gcugagccgc      660

agagaacaac agcccucugu gacaucccgg agcggaggca cccagguuca gcaaaccccu      720

gccucuugcc cccucgacag cgaccugucc gaggaugaag accuucagcu ggcuauggcc      780

uacucucuca gcgagaugga agcggccggg aagaaaccgg cuggaggcag agaggcccag      840

caccgccggc aggggagacc uaaggcucaa caucaggauc ccggacuggg cggcacacag      900

gagggggccc gcggagaagc cacgaagcgg uccccuagcc ccgaggaaaa agcuagcaga      960

ugucuuaucc uguga                                                       975


<210>  8360
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB3__Homo_sapiens__Q8WWF6

<400>  8360

Met Val Asp Tyr Tyr Glu Val Leu Asp Val Pro Arg Gln Ala Ser Ser 
1               5                   10                  15      


Glu Ala Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Arg Phe Lys Gln 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Asp Ile 
    50                  55                  60                  


Tyr Asp Arg Tyr Gly Glu Ala Gly Ala Glu Gly Gly Cys Thr Gly Gly 
65                  70                  75                  80  


Arg Pro Phe Glu Asp Pro Phe Glu Tyr Val Phe Ser Phe Arg Asp Pro 
                85                  90                  95      


Ala Asp Val Phe Arg Glu Phe Phe Gly Gly Gln Asp Pro Phe Ser Phe 
            100                 105                 110         


Asp Leu Leu Gly Asn Pro Leu Glu Asn Ile Leu Gly Gly Ser Glu Glu 
        115                 120                 125             


Leu Leu Gly Lys Gln Lys Gln Ser Val Cys Thr Pro Phe Leu Cys Leu 
    130                 135                 140                 


Gln 
145 


<210>  8361
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB3__Homo_sapiens__AAH17590

<400>  8361
augguggacu acuacgaggu gcuggacgug ccccggcagg ccucauccga ggccaucaag       60

aaggcguacc gcaagcuggc gcucaagugg caccccgaca aaaacccuga gaacaaggag      120

gaagcggaga ggagauucaa gcagguggcc gaggccuacg agguguuguc ggacgccaag      180

aaacgcgaua ucuaugaccg cuauggcgag gcgggcgcgg agggcggcug cacaggcggc      240

aggcccuucg aggaccccuu cgaguacguc uucagcuucc gcgacccagc cgacgucuuc      300

agggaguucu ucggcggcca ggacccauuc uccuuugacc ucuugggaaa cccgcuggag      360

aauauuuugg gggggucaga ggaacugcug gggaagcaga agcagagcgu cugcaccccu      420

uuucucugcc uucaguga                                                    438


<210>  8362
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB3__Homo_sapiens__AAH17590

<400>  8362
augguggacu acuacgaggu ccuggacgug ccccgccagg ccagcuccga ggccaucaag       60

aaggcguacc ggaagcucgc ccugaagugg cacccggaca agaaccccga gaacaaggag      120

gaggccgagc gccgguucaa gcaggucgcc gaggccuacg aggugcugag cgacgcgaag      180

aagcgcgaca ucuacgaccg guacggcgag gccggggccg agggcgggug caccggcggg      240

cgccccuucg aggaccccuu cgaguacgug uucuccuucc gggacccggc cgacguguuc      300

cgcgaguucu ucggcggcca ggaccccuuc agcuucgacc uccuggggaa cccccuggag      360

aacauccucg gcggguccga ggagcugcug ggcaagcaga agcagagcgu cugcaccccc      420

uuccucugcc ugcaguga                                                    438


<210>  8363
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB3__Homo_sapiens__AAH17590

<400>  8363
auggucgacu acuacgaggu ccucgacguc ccccgccagg ccuccuccga ggccaucaag       60

aaggccuacc gcaagcucgc ccucaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgagc gccgcuucaa gcaggucgcc gaggccuacg agguccucuc cgacgccaag      180

aagcgcgaca ucuacgaccg cuacggcgag gccggcgccg agggcggcug caccggcggc      240

cgccccuucg aggaccccuu cgaguacguc uucuccuucc gcgaccccgc cgacgucuuc      300

cgcgaguucu ucggcggcca ggaccccuuc uccuucgacc uccucggcaa cccccucgag      360

aacauccucg gcggcuccga ggagcuccuc ggcaagcaga agcaguccgu cugcaccccc      420

uuccucugcc uccaguga                                                    438


<210>  8364
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB3__Homo_sapiens__AAH17590

<400>  8364
augguggacu acuaugaggu ccuggauguu cccagacagg ccagcuccga agcuaucaag       60

aaagcauaca ggaagcucgc ccuuaaaugg cacccugaca agaacccaga gaauaaagaa      120

gaggcggaac ggcgcuucaa gcaaguggcu gaggccuaug agguacuguc ugaugcaaag      180

aaacgagaca uuuacgaucg uuauggcgaa gccggggcug agggagguug caccggcggg      240

agaccguuug aagaccccuu cgaguacgug uuuucauuca gggauccugc agacgucuuu      300

cgggaguucu uuggaggcca ggauccauuc aguuuugacu uguuagguaa cccccuggaa      360

aauauacuag ggggaagcga ggaacuccug ggcaagcaga aacaguccgu guguacaccu      420

uuccuuugcc ugcaauga                                                    438


<210>  8365
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB3__Homo_sapiens__AAH17590

<400>  8365
augguggacu acuacgaggu gcuggacgug cccagacagg ccagcagcga ggccaucaag       60

aaggccuaca gaaagcuggc ccugaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgaga gaagauucaa gcagguggcc gaggccuacg aggugcugag cgacgccaag      180

aagagagaca ucuacgacag auacggcgag gccggcgccg agggcggcug caccggcggc      240

agacccuucg aggaccccuu cgaguacgug uucagcuuca gagaccccgc cgacguguuc      300

agagaguucu ucggcggcca ggaccccuuc agcuucgacc ugcugggcaa cccccuggag      360

aacauccugg gcggcagcga ggagcugcug ggcaagcaga agcagagcgu gugcaccccc      420

uuccugugcc ugcaguga                                                    438


<210>  8366
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB3__Homo_sapiens__AAH17590

<400>  8366
augguggacu acuaugaggu ccuggauguu cccagacagg ccagcuccga agcuaucaag       60

aaagccuacc ggaagcucgc gcugaaaugg cacccugaca agaacccgga gaauaaagaa      120

gaggcugaac gcagauucaa gcaaguggcc gaggccuaug aggugcuuuc ugaugcuaag      180

aaacgggaca uuuacgaucg cuauggcgaa gccggggcug agggaggcug caccggggga      240

agacccuuug aagacccuuu cgaguacguc uuuagcuucc gggaucccgc cgacguguuu      300

cgcgaguucu uuggcgggca ggauccuuuc uccuuugacc ugcucggaaa cccccuggaa      360

aauauccuug gcggcucuga ggaacugcuc gggaagcaga aacagagcgu uuguacaccu      420

uuccugugcc ugcaauga                                                    438


<210>  8367
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB4__Homo_sapiens__Q9UDY4

<400>  8367

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  8368
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB4__Homo_sapiens__AAC14483

<400>  8368
auggggaaag acuauuauug cauuuuggga auugagaaag gagcuucaga ugaagauauu       60

aaaaaggcuu accgaaaaca agcccucaaa uuucauccgg acaagaacaa aucuccucag      120

gcagaggaaa aauuuaaaga ggucgcagaa gcuuaugaag uauugaguga uccuaaaaag      180

agagaaauau augaucaguu uggggaggaa ggguugaaag gaggagcagg agguacugau      240

ggacaaggag guaccuuccg guacaccuuu cauggcgauc cucaugcuac auuugcugca      300

uuuuucggag gguccaaccc cuuugaaauu uucuuuggaa gacgaauggg uggugguaga      360

gauucugaag aaauggaaau agauggugau ccuuuuagug ccuuugguuu cagcaugaau      420

ggauauccaa gagacaggaa uucugugggg ccaucccgcc ucaaacaaga uccuccaguu      480

auucaugaac uuagaguauc acuugaagag auauauagug guuguaccaa acggaugaag      540

auuucucgaa aaaggcuaaa cgcugaugga aggaguuaca gaucugagga caaaauucuu      600

accauugaga uuaaaaaagg guggaaagaa ggcaccaaaa uuacuuuucc aagagaagga      660

gaugaaacac caaauaguau uccagcagac auuguuuuua ucauuaaaga caaagaucau      720

ccaaaauuua aaagggaugg aucaaauaua auuuauacug cuaaaauuag uuuacgagag      780

gcauugugug gcugcucaau uaauguacca acacuggaug gaagaaacau accuauguca      840

guaaaugaua uugugaaacc cggaaugagg agaagaauua uuggauaugg gcugccauuu      900

ccaaaaaauc cugaccaacg uggugaccuu cuaauagaau uugagguguc cuucccagau      960

acuauaucuu cuucauccaa agaaguacuu aggaaacauc uuccugccuc auag           1014


<210>  8369
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB4__Homo_sapiens__AAC14483

<400>  8369
augggcaagg acuacuacug cauccugggg aucgagaagg gcgccagcga cgaggacauc       60

aagaaggccu accgcaagca ggcgcucaag uuccaccccg acaagaacaa guccccgcag      120

gccgaggaga aguucaagga gguggccgag gccuacgagg uccugagcga ccccaagaag      180

cgggagaucu acgaccaguu cggggaggag ggccugaagg gcggggccgg cgggaccgac      240

ggccagggcg ggaccuuccg cuacacguuc cacggggacc cccacgcgac cuucgccgcc      300

uucuucggcg gcuccaaccc cuucgagauc uucuucgggc ggcgcauggg cgggggccgg      360

gacagcgagg agauggagau cgacggcgac ccguucuccg ccuucggguu cagcaugaac      420

ggcuaccccc gcgaccggaa cuccgugggg cccagccgcc ucaagcagga cccgcccgug      480

auccacgagc ugcgggucuc ccuggaggag aucuacagcg gcugcaccaa gcgcaugaag      540

aucucccgga agcgccucaa cgcggacggg cggagcuacc gcuccgagga caagauccug      600

accaucgaga ucaagaaggg cuggaaggag ggcacgaaga ucaccuuccc ccgggagggg      660

gacgagaccc ccaacagcau ccccgccgac aucguguuca ucaucaagga caaggaccac      720

ccgaaguuca agcgcgacgg cuccaacauc aucuacaccg ccaagaucag ccugcgggag      780

gcccucugcg ggugcuccau caacgugccc acgcuggacg gccgcaacau ccccaugagc      840

gucaacgaca ucgugaagcc cgggaugcgg cgccggauca ucggcuacgg ccugccguuc      900

cccaagaacc ccgaccagcg cggggaccuc cugaucgagu ucgagguguc cuuccccgac      960

accaucagca gcuccagcaa ggagguccug cgcaagcacc ucccggccuc cuga           1014


<210>  8370
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB4__Homo_sapiens__AAC14483

<400>  8370
augggcaagg acuacuacug cauccucggc aucgagaagg gcgccuccga cgaggacauc       60

aagaaggccu accgcaagca ggcccucaag uuccaccccg acaagaacaa guccccccag      120

gccgaggaga aguucaagga ggucgccgag gccuacgagg uccucuccga ccccaagaag      180

cgcgagaucu acgaccaguu cggcgaggag ggccucaagg gcggcgccgg cggcaccgac      240

ggccagggcg gcaccuuccg cuacaccuuc cacggcgacc cccacgccac cuucgccgcc      300

uucuucggcg gcuccaaccc cuucgagauc uucuucggcc gccgcauggg cggcggccgc      360

gacuccgagg agauggagau cgacggcgac cccuucuccg ccuucggcuu cuccaugaac      420

ggcuaccccc gcgaccgcaa cuccgucggc cccucccgcc ucaagcagga cccccccguc      480

auccacgagc uccgcgucuc ccucgaggag aucuacuccg gcugcaccaa gcgcaugaag      540

aucucccgca agcgccucaa cgccgacggc cgcuccuacc gcuccgagga caagauccuc      600

accaucgaga ucaagaaggg cuggaaggag ggcaccaaga ucaccuuccc ccgcgagggc      660

gacgagaccc ccaacuccau ccccgccgac aucgucuuca ucaucaagga caaggaccac      720

cccaaguuca agcgcgacgg cuccaacauc aucuacaccg ccaagaucuc ccuccgcgag      780

gcccucugcg gcugcuccau caacgucccc acccucgacg gccgcaacau ccccaugucc      840

gucaacgaca ucgucaagcc cggcaugcgc cgccgcauca ucggcuacgg ccuccccuuc      900

cccaagaacc ccgaccagcg cggcgaccuc cucaucgagu ucgaggucuc cuuccccgac      960

accaucuccu ccuccuccaa ggagguccuc cgcaagcacc uccccgccuc cuga           1014


<210>  8371
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB4__Homo_sapiens__AAC14483

<400>  8371
augggcaagg acuacuauug cauccugggg auugagaaag gagccagcga ugaagacaua       60

aagaaggcuu acagaaaaca ggcacucaaa uuccaccccg auaagaacaa guccccucaa      120

gccgaggaaa aauuuaagga gguggcggag gcuuaugaag uccuuucuga cccgaaaaag      180

agggagaucu acgaucaguu cggugaagag ggccugaaag ggggagccgg cgguaccgac      240

gggcagggag gcacauuucg guauacuuuc cauggcgauc cacacgcaac guuugccgcu      300

uucuuugggg gaucaaaucc cuucgaaauc uuuuucgguc gccgaauggg cgggggacgu      360

gacagugagg agauggaaau ugauggcgac ccuuuuagcg cauucgguuu uuccaugaac      420

ggguacccaa gagauaggaa cucuguugga cccucgcggu ugaagcagga cccuccagug      480

auucaugagu uacgcguauc acuggaagag aucuauagcg gcuguaccaa gagaaugaaa      540

auaaguagga agcggcuaaa ugccgauggc cgcuccuacc gaucugaaga caaaauccuc      600

acaauugaga ucaagaaagg guggaaggag ggaacuaaaa uuaccuuccc cagagaaggu      660

gacgagacac cuaauagcau cccagcugau auaguguuca uuaucaagga caaggaucac      720

ccgaaauuua agagggacgg cuccaacauu aucuacaccg ccaaaaucuc acugcgggaa      780

gcgcuuugcg gguguaguau uaaugucccc acucuggaug gacguaacau accuaugagc      840

gugaaugaca ucguuaagcc aggcaugcgc agaaggauua ucgguuaugg guugcccuuc      900

ccuaaaaacc cagaucaacg gggcgaccuc cugauagagu uugaaguguc uuuccccgau      960

acaauuuccu caagcaguaa ggagguccug cgaaagcauc ucccggcauc uuga           1014


<210>  8372
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB4__Homo_sapiens__AAC14483

<400>  8372
augggcaagg acuacuacug cauccugggc aucgagaagg gcgccagcga cgaggacauc       60

aagaaggccu acagaaagca ggcccugaag uuccaccccg acaagaacaa gagcccccag      120

gccgaggaga aguucaagga gguggccgag gccuacgagg ugcugagcga ccccaagaag      180

agagagaucu acgaccaguu cggcgaggag ggccugaagg gcggcgccgg cggcaccgac      240

ggccagggcg gcaccuucag auacaccuuc cacggcgacc cccacgccac cuucgccgcc      300

uucuucggcg gcagcaaccc cuucgagauc uucuucggca gaagaauggg cggcggcaga      360

gacagcgagg agauggagau cgacggcgac cccuucagcg ccuucggcuu cagcaugaac      420

ggcuacccca gagacagaaa cagcgugggc cccagcagac ugaagcagga cccccccgug      480

auccacgagc ugagagugag ccuggaggag aucuacagcg gcugcaccaa gagaaugaag      540

aucagcagaa agagacugaa cgccgacggc agaagcuaca gaagcgagga caagauccug      600

accaucgaga ucaagaaggg cuggaaggag ggcaccaaga ucaccuuccc cagagagggc      660

gacgagaccc ccaacagcau ccccgccgac aucguguuca ucaucaagga caaggaccac      720

cccaaguuca agagagacgg cagcaacauc aucuacaccg ccaagaucag ccugagagag      780

gcccugugcg gcugcagcau caacgugccc acccuggacg gcagaaacau ccccaugagc      840

gugaacgaca ucgugaagcc cggcaugaga agaagaauca ucggcuacgg ccugcccuuc      900

cccaagaacc ccgaccagag aggcgaccug cugaucgagu ucgaggugag cuuccccgac      960

accaucagca gcagcagcaa ggaggugcug agaaagcacc ugcccgccag cuga           1014


<210>  8373
<211>  1014
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB4__Homo_sapiens__AAC14483

<400>  8373
augggcaagg acuacuauug cauccugggg auugagaaag gagccagcga ugaagacauc       60

aagaaggcuu acagaaaaca ggcccucaaa uuccaccccg auaagaacaa guccccucaa      120

gcggaggaaa aauuuaagga gguggcugaa gccuaugagg uccugucuga cccgaaaaag      180

cgggagauuu acgaucaguu cggcgaagag gggcuuaaag gaggcgccgg gggaaccgac      240

ggccagggcg ggacauuucg cuauacguuc cauggagauc cccacgcuac cuuugccgcu      300

uucuuuggcg ggagcaaucc uuucgaaauc uuuuucggaa gacggauggg cgggggacgc      360

gacuccgagg agauggaaau ugauggcgac cccuuuucug ccuucggcuu uagcaugaac      420

ggguacccua gagaucgcaa uuccguugga cccucucggc ugaagcagga cccuccggug      480

auccaugagc ucagagugag ccuggaagag aucuauuccg gcuguacaaa gcggaugaaa      540

auuagccgca agagacuuaa cgcggauggg cggucuuacc gcuccgaaga caaaauccug      600

accauugaga ucaagaaagg auggaaggag ggcacaaaaa uuaccuuccc cagagaaggg      660

gacgagacac cuaauagcau ccccgccgau auugucuuca ucaucaagga caaggaucac      720

ccuaaauuua agcgggacgg aucuaacauu aucuacaccg cuaaaauuuc ccuccgcgaa      780

gcccugugcg gcuguagcau caaugugccc acgcuggaug gcagaaacau uccgaugucu      840

guuaaugaca ucgugaagcc ugggaugcgg agacgcauca uuggauaugg ccuccccuuc      900

ccuaaaaacc ccgaucaaag aggggaccug cuuaucgagu uugaagucuc cuuccccgau      960

accauuagcu ccucuagcaa ggaggugcug cggaagcauc ucccugcuuc cuga           1014


<210>  8374
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB5__Homo_sapiens__O75953

<400>  8374

Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly Ala Asn 
1               5                   10                  15      


Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys Tyr His 
            20                  25                  30          


Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys Glu Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly Leu Tyr 
    50                  55                  60                  


Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile Phe Phe 
            100                 105                 110         


Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro Asp Asp 
        115                 120                 125             


Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly Arg Phe 
    130                 135                 140                 


Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu Pro Leu 
145                 150                 155                 160 


Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu Leu Arg 
                165                 170                 175     


Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met Lys Ile 
            180                 185                 190         


Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr Glu Asp 
        195                 200                 205             


Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly Thr Lys 
    210                 215                 220                 


Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe Arg Arg 
                245                 250                 255     


Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys Glu Ala 
            260                 265                 270         


Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg Val Ile 
        275                 280                 285             


Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys Arg Leu 
    290                 295                 300                 


Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg Gly Asp 
305                 310                 315                 320 


Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr Pro Gln 
                325                 330                 335     


Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
            340                 345             


<210>  8375
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB5__Homo_sapiens__AAC35860

<400>  8375
augggaaaag auuauuacaa gauucuuggg aucccaucgg gggccaacga ggaugagauc       60

aagaaagccu accggaagau ggccuugaag uaccacccag acaagaauaa agaacccaac      120

gcugaggaga aguuuaagga gauugcagag gccuaugaug ugcuaaguga ccccaagaaa      180

cggggccugu augaccagua uggggaggaa ggccugaaga ccggcggugg cacaucaggu      240

ggcuccagug gcuccuuuca cuacaccuuu cauggggacc cccaugccac cuuugccucc      300

uucuuuggug gcuccaaccc cuucgauauc uucuuugcca gcagccgcuc cacucggccc      360

uucaguggcu uugacccaga ugacauggau guggaugaag augaggaccc auuuggcgcu      420

uucggccguu uuggcuucaa ugggcugagu agggguccaa ggcgagcccc agaaccacug      480

uacccucggc gcaaggugca ggacccccca guggugcacg agcugcgggu gucccuggag      540

gagaucuacc auggcuccac caagcgcaug aagaucacaa ggcgucgccu caacccugau      600

gggcgaacug ugcgcaccga ggacaagauc cugcacauag ucaucaagcg uggcuggaag      660

gaaggcacca agaucaccuu ccccaaagaa ggcgacgcca caccugacaa caucccugcu      720

gacaucgucu uugugcucaa agacaagccc caugcacacu uccgccgaga uggcaccaac      780

gugcucuaca gugcccugau cagccucaag gaggcgcugu guggcugcac ugugaacauu      840

cccacuaucg acggccgagu gaucccuuug cccugcaaug augucaucaa gccaggcacc      900

gugaagagac uccgugggga gggccuuccc uuccccaaag ugccaacuca gcgaggagac      960

cucauuguug aguucaaagu ucgcuuccca gacagauuaa caccacagac aagacagauc     1020

cuuaagcagc accuacccug uuccuag                                         1047


<210>  8376
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB5__Homo_sapiens__AAC35860

<400>  8376
augggcaagg acuacuacaa gauccugggg auccccagcg gcgccaacga ggacgagauc       60

aagaaggccu accgcaagau ggcgcucaag uaccacccgg acaagaacaa ggagcccaac      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg ugcuguccga ccccaagaag      180

cgggggcugu acgaccagua cggcgaggag gggcucaaga ccggcggcgg gaccagcggc      240

ggguccagcg gcuccuucca cuacacguuc cacggggacc cccacgccac cuucgcgagc      300

uucuucggcg gcuccaaccc guucgacauc uucuucgcca gcucccgcag cacccggccc      360

uucuccgggu ucgaccccga cgacauggac gucgacgagg acgaggaccc cuucggcgcc      420

uucgggcgcu ucggcuucaa cggccugagc cgggggccgc gccgggcccc cgagccccug      480

uacccccgcc ggaaggugca ggacccgccc gugguccacg agcuccgcgu gucccuggag      540

gagaucuacc acggcagcac caagcggaug aagaucacgc gccggcgccu gaaccccgac      600

gggcggaccg ugcgcaccga ggacaagauc cuccacaucg ucaucaagcg gggcuggaag      660

gaggggacca agaucacguu ccccaaggag ggcgacgcga ccccggacaa cauccccgcc      720

gacaucgugu ucgugcugaa ggacaagccc cacgcccacu uccgccggga cggcaccaac      780

guccuguacu ccgcccucau cagccugaag gaggcccugu gcgggugcac cgugaacauc      840

cccacgaucg acggccgcgu gaucccgcuc cccugcaacg acgucaucaa gcccgggacc      900

gugaagcggc ugcgcggcga ggggcugccc uucccgaagg ugcccaccca gcgcggcgac      960

cucaucgucg aguucaaggu gcgguucccc gaccgccuga cgccccagac ccggcagauc     1020

cugaagcagc accucccgug cuccuga                                         1047


<210>  8377
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB5__Homo_sapiens__AAC35860

<400>  8377
augggcaagg acuacuacaa gauccucggc auccccuccg gcgccaacga ggacgagauc       60

aagaaggccu accgcaagau ggcccucaag uaccaccccg acaagaacaa ggagcccaac      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg uccucuccga ccccaagaag      180

cgcggccucu acgaccagua cggcgaggag ggccucaaga ccggcggcgg caccuccggc      240

ggcuccuccg gcuccuucca cuacaccuuc cacggcgacc cccacgccac cuucgccucc      300

uucuucggcg gcuccaaccc cuucgacauc uucuucgccu ccucccgcuc cacccgcccc      360

uucuccggcu ucgaccccga cgacauggac gucgacgagg acgaggaccc cuucggcgcc      420

uucggccgcu ucggcuucaa cggccucucc cgcggccccc gccgcgcccc cgagccccuc      480

uacccccgcc gcaaggucca ggaccccccc gucguccacg agcuccgcgu cucccucgag      540

gagaucuacc acggcuccac caagcgcaug aagaucaccc gccgccgccu caaccccgac      600

ggccgcaccg uccgcaccga ggacaagauc cuccacaucg ucaucaagcg cggcuggaag      660

gagggcacca agaucaccuu ccccaaggag ggcgacgcca cccccgacaa cauccccgcc      720

gacaucgucu ucguccucaa ggacaagccc cacgcccacu uccgccgcga cggcaccaac      780

guccucuacu ccgcccucau cucccucaag gaggcccucu gcggcugcac cgucaacauc      840

cccaccaucg acggccgcgu caucccccuc cccugcaacg acgucaucaa gcccggcacc      900

gucaagcgcc uccgcggcga gggccucccc uuccccaagg uccccaccca gcgcggcgac      960

cucaucgucg aguucaaggu ccgcuucccc gaccgccuca ccccccagac ccgccagauc     1020

cucaagcagc accuccccug cuccuga                                         1047


<210>  8378
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB5__Homo_sapiens__AAC35860

<400>  8378
augggcaagg acuacuauaa aauccugggg auucccagcg gagccaacga ggaugaaaua       60

aagaaggcuu acagaaaaau ggcacucaaa uaucacccug acaagaauaa ggagccaaac      120

gccgaagaga aauucaagga aaucgcggag gcuuacgaug ugcuuuccga cccgaaaaag      180

aggggucugu augaucagua cggcgaggaa ggguugaaaa ccggaggcgg uacaucuggg      240

ggaucaagug gcagcuuuca uuauacuuuc cacggcgacc cccaugccac guuugcaucc      300

uucuuugggg gaucuaaucc uuucgauauu uucuucgccu cgucacggag cacccgccca      360

uuuagugguu ucgaccccga ugacauggau gucgacgagg augaagaccc uuuuggcgcu      420

uucgggcgau uuggauucaa cggcuuaucc cgugguccaa gaagggcacc cgagccucug      480

uacccacggc gcaagguuca agacccgccc gugguacacg agcuaagagu gucucucgaa      540

gagaucuacc augggagcac aaagaggaug aaaauuacuc ggcgccgacu gaauccugau      600

ggaagaaccg ucaggacaga agacaagauc cuucacauag ugaucaaacg gggcuggaag      660

gagggcacca aaauuacuuu cccaaaggaa ggggaugcca cacccgacaa caucccugcu      720

gauauuguuu uugugcugaa agacaagcca cacgcccauu uccgucgcga uggaaccaau      780

gucuuguauu ccgcgcucau cucacugaag gaggcacugu gcgguuguac ggugaacaua      840

cccacuauug acggcagagu aaucccgcuc ccuugcaaug auguuauuaa acccgggacc      900

gugaagaggu uacggggaga gggccugcca uuuccuaaag uccccacaca gcgaggugac      960

cuuaucgugg aauuuaaggu gcgcuuucca gauagauuga cuccccagac caggcagauc     1020

cugaaacaac accuaccuug uaguuga                                         1047


<210>  8379
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB5__Homo_sapiens__AAC35860

<400>  8379
augggcaagg acuacuacaa gauccugggc auccccagcg gcgccaacga ggacgagauc       60

aagaaggccu acagaaagau ggcccugaag uaccaccccg acaagaacaa ggagcccaac      120

gccgaggaga aguucaagga gaucgccgag gccuacgacg ugcugagcga ccccaagaag      180

agaggccugu acgaccagua cggcgaggag ggccugaaga ccggcggcgg caccagcggc      240

ggcagcagcg gcagcuucca cuacaccuuc cacggcgacc cccacgccac cuucgccagc      300

uucuucggcg gcagcaaccc cuucgacauc uucuucgcca gcagcagaag caccagaccc      360

uucagcggcu ucgaccccga cgacauggac guggacgagg acgaggaccc cuucggcgcc      420

uucggcagau ucggcuucaa cggccugagc agaggcccca gaagagcccc cgagccccug      480

uaccccagaa gaaaggugca ggaccccccc guggugcacg agcugagagu gagccuggag      540

gagaucuacc acggcagcac caagagaaug aagaucacca gaagaagacu gaaccccgac      600

ggcagaaccg ugagaaccga ggacaagauc cugcacaucg ugaucaagag aggcuggaag      660

gagggcacca agaucaccuu ccccaaggag ggcgacgcca cccccgacaa cauccccgcc      720

gacaucgugu ucgugcugaa ggacaagccc cacgcccacu ucagaagaga cggcaccaac      780

gugcuguaca gcgcccugau cagccugaag gaggcccugu gcggcugcac cgugaacauc      840

cccaccaucg acggcagagu gaucccccug cccugcaacg acgugaucaa gcccggcacc      900

gugaagagac ugagaggcga gggccugccc uuccccaagg ugcccaccca gagaggcgac      960

cugaucgugg aguucaaggu gagauucccc gacagacuga ccccccagac cagacagauc     1020

cugaagcagc accugcccug cagcuga                                         1047


<210>  8380
<211>  1047
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB5__Homo_sapiens__AAC35860

<400>  8380
augggcaagg acuacuauaa aauccugggg auucccagcg gagccaacga agaugaaauc       60

aagaaggcuu acagaaaaau ggcccucaaa uaucacccug acaagaauaa ggagccgaac      120

gcggaagaga aauucaagga aauugcugag gccuacgaug ugcuguccga ccccaaaaag      180

cggggccuuu augaucagua cggggaggaa ggacugaaaa ccggcggggg aacaucuggc      240

ggcagcuccg ggucuuuuca cuauacguuc cacggagacc cucaugccac cuuugcuagc      300

uucuuuggcg gguccaaucc cuucgauauc uuuuucgccu cuagccgcuc cacaagaccu      360

uuuagcggau ucgaccccga ugacauggau gucgacgagg augaagaccc uuuuggcgcu      420

uucgggcggu uuggauucaa cggccucucu cgcggcccga gacgggcccc cgagccucug      480

uacccccgca gaaagguuca agacccuccc guggugcacg agcuucgggu cucccuggaa      540

gagauuuacc augggagcac caagcgcaug aaaaucacaa gacggcgccu caauccggau      600

ggaagaaccg ugcggacaga agacaagauc cugcacauug uuaucaaacg cggcuggaag      660

gaggggacca aaauuacguu cccuaaggaa ggagaugcga cccccgacaa caucccugcc      720

gauauugugu uuguccugaa agacaagccc cacgcucauu ucagacggga uggcacaaau      780

gugcucuauu cugcccugau cucccuuaag gaggcucugu gcggguguac cguuaacauu      840

cccacaaucg acggaagagu gaucccucuc ccgugcaaug augucauuaa acccggcacc      900

gugaagcgcc ugcggggcga ggggcuuccu uuucccaaag ugccuacgca gagaggagac      960

cugaucgucg aguucaaggu ucgcuuuccc gaucggcuca caccgcagac cagacagauu     1020

cugaaacaac aucugccuug uagcuga                                         1047


<210>  8381
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB6__Homo_sapiens__O75190

<400>  8381

Met Val Asp Tyr Tyr Glu Val Leu Gly Val Gln Arg His Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Lys Phe Lys Gln 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Asp Ile 
    50                  55                  60                  


Tyr Asp Lys Tyr Gly Lys Glu Gly Leu Asn Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ser His Phe Asp Ser Pro Phe Glu Phe Gly Phe Thr Phe Arg Asn Pro 
                85                  90                  95      


Asp Asp Val Phe Arg Glu Phe Phe Gly Gly Arg Asp Pro Phe Ser Phe 
            100                 105                 110         


Asp Phe Phe Glu Asp Pro Phe Glu Asp Phe Phe Gly Asn Arg Arg Gly 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Arg Gly Thr Gly Ser Phe Phe Ser Ala Phe 
    130                 135                 140                 


Ser Gly Phe Pro Ser Phe Gly Ser Gly Phe Ser Ser Phe Asp Thr Gly 
145                 150                 155                 160 


Phe Thr Ser Phe Gly Ser Leu Gly His Gly Gly Leu Thr Ser Phe Ser 
                165                 170                 175     


Ser Thr Ser Phe Gly Gly Ser Gly Met Gly Asn Phe Lys Ser Ile Ser 
            180                 185                 190         


Thr Ser Thr Lys Met Val Asn Gly Arg Lys Ile Thr Thr Lys Arg Ile 
        195                 200                 205             


Val Glu Asn Gly Gln Glu Arg Val Glu Val Glu Glu Asp Gly Gln Leu 
    210                 215                 220                 


Lys Ser Leu Thr Ile Asn Gly Val Ala Asp Asp Asp Ala Leu Ala Glu 
225                 230                 235                 240 


Glu Arg Met Arg Arg Gly Gln Asn Ala Leu Pro Ala Gln Pro Ala Gly 
                245                 250                 255     


Leu Arg Pro Pro Lys Pro Pro Arg Pro Ala Ser Leu Leu Arg His Ala 
            260                 265                 270         


Pro His Cys Leu Ser Glu Glu Glu Gly Glu Gln Asp Arg Pro Arg Ala 
        275                 280                 285             


Pro Gly Pro Trp Asp Pro Leu Ala Ser Ala Ala Gly Leu Lys Glu Gly 
    290                 295                 300                 


Gly Lys Arg Lys Lys Gln Lys Gln Arg Glu Glu Ser Lys Lys Lys Lys 
305                 310                 315                 320 


Ser Thr Lys Gly Asn His 
                325     


<210>  8382
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB6__Homo_sapiens__AAH02446

<400>  8382
augguggauu acuaugaagu ucuaggcgug cagagacaug ccucacccga ggauauuaaa       60

aaggcauauc ggaaacuggc acugaagugg cauccagaua aaaauccuga gaauaaagaa      120

gaagcagaga gaaaauucaa gcaaguagcg gaggcauaug aagugcuguc ggaugcuaag      180

aaacgggaca ucuaugacaa auauggcaaa gaaggauuaa augguggagg aggaggugga      240

agucauuuug acaguccauu ugaauuuggc uucacauucc guaacccaga ugaugucuuc      300

agggaauuuu uugguggaag ggacccauuu ucauuugacu ucuuugaaga cccuuuugag      360

gacuucuuug ggaaucgaag ggguccccga ggaagcagaa gccgagggac ggggucguuu      420

uucucugcgu ucaguggauu uccgucuuuu ggaaguggau uuucuucuuu ugauacagga      480

uuuacuucau uugggucacu aggucacggg ggccucacuu cauucucuuc cacgucauuu      540

ggugguagug gcaugggcaa cuucaaaucg auaucaacuu caacuaaaau gguuaauggc      600

agaaaaauca cuacaaagag aauugucgag aacggucaag aaagaguaga aguugaagaa      660

gauggccagu uaaaguccuu aacaauaaau gguguggccg acgacgaugc ccucgcugag      720

gagcgcaugc ggagaggcca gaacgcccug ccagcccagc cugccggccu ccgcccgccg      780

aagccgcccc ggccugccuc gcugcugaga cacgcgccuc acugucucuc ugaggaggag      840

ggcgagcagg accgaccucg ggcacccggg cccugggacc cccucgcguc cgcagcagga      900

uugaaagaag guggcaagag gaagaagcag aagcagagag aggagucgaa gaagaagaag      960

ucgaccaaag gcaaucacua g                                                981


<210>  8383
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB6__Homo_sapiens__AAH02446

<400>  8383
augguggacu acuacgaggu ccugggcgug cagcgccacg ccagccccga ggacaucaag       60

aaggccuacc ggaagcucgc gcugaagugg cacccggaca agaaccccga gaacaaggag      120

gaggccgagc gcaaguucaa gcaggucgcc gaggccuacg aggugcugag cgacgccaag      180

aagcgggaca ucuacgacaa guacgggaag gagggccuca acgggggcgg gggcggcggg      240

agccacuucg acucccccuu cgaguucggc uucaccuucc gcaaccccga cgacguguuc      300

cgggaguucu ucgggggccg cgacccguuc agcuucgacu ucuucgagga ccccuucgag      360

gacuucuucg ggaaccggcg cggcccccgg ggcucccgca gccgggggac cggcuccuuc      420

uucagcgcgu ucuccggguu ccccagcuuc ggcuccggcu ucagcuccuu cgacacgggg      480

uucaccagcu ucggcucccu ggggcacggc gggcugacca gcuucuccag caccuccuuc      540

ggcggcagcg ggaugggcaa cuucaagagc aucuccacga gcaccaagau ggugaacggg      600

cgcaagauca ccaccaagcg gaucgucgag aacggccagg agcgcgugga gguggaggag      660

gacgggcagc ucaagucccu gacgaucaac ggcgucgccg acgacgacgc ccuggccgag      720

gagcggaugc gccggggcca gaacgcgcuc ccggcccagc ccgccgggcu gcgcccgccc      780

aagccgcccc ggcccgccag ccugcuccgc cacgcgcccc acugccuguc cgaggaggag      840

ggcgagcagg accggccccg cgcccccggg cccugggacc cccuggccag cgccgccggc      900

cucaaggagg gcgggaagcg caagaagcag aagcagcggg aggaguccaa gaagaagaag      960

uccaccaagg gcaaccacug a                                                981


<210>  8384
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB6__Homo_sapiens__AAH02446

<400>  8384
auggucgacu acuacgaggu ccucggcguc cagcgccacg ccucccccga ggacaucaag       60

aaggccuacc gcaagcucgc ccucaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgagc gcaaguucaa gcaggucgcc gaggccuacg agguccucuc cgacgccaag      180

aagcgcgaca ucuacgacaa guacggcaag gagggccuca acggcggcgg cggcggcggc      240

ucccacuucg acucccccuu cgaguucggc uucaccuucc gcaaccccga cgacgucuuc      300

cgcgaguucu ucggcggccg cgaccccuuc uccuucgacu ucuucgagga ccccuucgag      360

gacuucuucg gcaaccgccg cggcccccgc ggcucccgcu cccgcggcac cggcuccuuc      420

uucuccgccu ucuccggcuu ccccuccuuc ggcuccggcu ucuccuccuu cgacaccggc      480

uucaccuccu ucggcucccu cggccacggc ggccucaccu ccuucuccuc caccuccuuc      540

ggcggcuccg gcaugggcaa cuucaagucc aucuccaccu ccaccaagau ggucaacggc      600

cgcaagauca ccaccaagcg caucgucgag aacggccagg agcgcgucga ggucgaggag      660

gacggccagc ucaagucccu caccaucaac ggcgucgccg acgacgacgc ccucgccgag      720

gagcgcaugc gccgcggcca gaacgcccuc cccgcccagc ccgccggccu ccgccccccc      780

aagccccccc gccccgccuc ccuccuccgc cacgcccccc acugccucuc cgaggaggag      840

ggcgagcagg accgcccccg cgcccccggc cccugggacc cccucgccuc cgccgccggc      900

cucaaggagg gcggcaagcg caagaagcag aagcagcgcg aggaguccaa gaagaagaag      960

uccaccaagg gcaaccacug a                                                981


<210>  8385
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB6__Homo_sapiens__AAH02446

<400>  8385
augguggacu acuaugaggu ccugggcguu cagagacacg ccagccccga agauaucaag       60

aaggcuuaca ggaaacucgc acuuaaaugg cauccugaca agaacccaga gaauaaagaa      120

gaggccgaac ggaaguucaa gcaaguggcg gaggcuuaug agguacuguc cgaugccaaa      180

aagcgcgaca uuuacgauaa auaugggaag gaaggauuga acgguggcgg gggaggcggu      240

ucucacuuug acucaccguu cgaguuuggg uucaccuuuc gaaaucccga ugacguguuc      300

cgugaauuuu ucggaggcag agauccuuuu aguuucgacu uuuucgagga uccauuugag      360

gacuucuucg gcaacaggcg ggggccccgc ggaagcagau ccagggguac aggcucguuu      420

uucucugcau uuucaggguu cccuagcuuu ggaaguggcu ucuccucuuu ugauacuggu      480

uucacgagcu uuggguccuu aggacauggc ggccugaccu cauucaguag cacaucuuuu      540

gggggauccg guaugggcaa uuucaaauca auaagcacca guacuaagau ggucaacggg      600

cggaagauca caaccaaacg cauuguggaa aauggacagg agcgaguuga aguggaggaa      660

gacggccagc uaaagucucu cacuaucaac ggugucgccg acgaugacgc ucuggcagag      720

gagagaauga ggcgggggca gaaugcccuu ccagcucaac ccgccggccu gcguccucca      780

aaaccgcccc gcccugcguc cuugcucaga cacgcaccac auugccugag cgaagaggaa      840

ggagagcagg auaggccccg ggccccuggc ccaugggacc cccuggcuuc ggccgcaggg      900

cucaaggaag gagguaaacg aaagaaacag aagcagcgcg aggagucuaa gaaaaagaaa      960

uccacaaagg gcaaccacug a                                                981


<210>  8386
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB6__Homo_sapiens__AAH02446

<400>  8386
augguggacu acuacgaggu gcugggcgug cagagacacg ccagccccga ggacaucaag       60

aaggccuaca gaaagcuggc ccugaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgaga gaaaguucaa gcagguggcc gaggccuacg aggugcugag cgacgccaag      180

aagagagaca ucuacgacaa guacggcaag gagggccuga acggcggcgg cggcggcggc      240

agccacuucg acagccccuu cgaguucggc uucaccuuca gaaaccccga cgacguguuc      300

agagaguucu ucggcggcag agaccccuuc agcuucgacu ucuucgagga ccccuucgag      360

gacuucuucg gcaacagaag aggccccaga ggcagcagaa gcagaggcac cggcagcuuc      420

uucagcgccu ucagcggcuu ccccagcuuc ggcagcggcu ucagcagcuu cgacaccggc      480

uucaccagcu ucggcagccu gggccacggc ggccugacca gcuucagcag caccagcuuc      540

ggcggcagcg gcaugggcaa cuucaagagc aucagcacca gcaccaagau ggugaacggc      600

agaaagauca ccaccaagag aaucguggag aacggccagg agagagugga gguggaggag      660

gacggccagc ugaagagccu gaccaucaac ggcguggccg acgacgacgc ccuggccgag      720

gagagaauga gaagaggcca gaacgcccug cccgcccagc ccgccggccu gagacccccc      780

aagcccccca gacccgccag ccugcugaga cacgcccccc acugccugag cgaggaggag      840

ggcgagcagg acagacccag agcccccggc cccugggacc cccuggccag cgccgccggc      900

cugaaggagg gcggcaagag aaagaagcag aagcagagag aggagagcaa gaagaagaag      960

agcaccaagg gcaaccacug a                                                981


<210>  8387
<211>  981
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB6__Homo_sapiens__AAH02446

<400>  8387
augguggacu acuaugaggu ccugggcguu cagagacacg ccagccccga agauaucaag       60

aaggcuuacc ggaaacucgc ccugaaaugg cauccugaca agaacccgga gaauaaagaa      120

gaggcggaac gcaaguucaa gcaaguggcu gaggccuaug aggugcuuuc cgaugccaaa      180

aagagagaca uuuacgauaa auaugggaag gaaggacuga acggcggggg aggcggggga      240

ucucacuuug acagccccuu cgaguuuggc uucaccuuuc ggaauccuga ugacgucuuc      300

cgcgaauuuu ucggcgggag agaucccuuu uccuucgacu uuuucgagga uccuuuugag      360

gacuucuucg gaaaccggcg cggccccaga gggucucgga gccgcggaac aggcuccuuu      420

uucucugcuu uuagcggguu cccuuccuuu ggaagcggcu ucucuuccuu ugauacgggc      480

uucaccagcu uugggucucu cggacauggc gggcugacau ccuucagcuc uaccuccuuu      540

ggaggcagcg ggaugggaaa uuucaaaucc aucucuacaa gcaccaagau ggugaacggc      600

agaaagauua caaccaaacg gaucguugaa aauggccagg agcgcgugga agucgaggaa      660

gacgggcagc uuaagucccu gacgauuaac ggaguggccg acgaugacgc ucucgccgag      720

gagagaaugc ggcgcggcca gaaugcgcug ccggcccaac ccgcugggcu gagaccuccc      780

aaaccucccc ggccggccag ccuccugaga cacgcuccuc auugccuuuc ugaagaggaa      840

ggagagcagg aucgcccccg ggccccuggc cccugggacc cccuggcguc cgccgcuggg      900

cucaaggaag gcggaaaaag aaagaaacag aagcagcgcg aggagagcaa gaaaaagaaa      960

ucuaccaagg gcaaccacug a                                                981


<210>  8388
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB7__Homo_sapiens__Q7Z6W7

<400>  8388

Met Val Asp Tyr Tyr Glu Val Leu Gly Leu Gln Arg Tyr Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr His Lys Val Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Lys Phe Lys Glu 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asn Asp Glu Lys Arg Asp Ile 
    50                  55                  60                  


Tyr Asp Lys Tyr Gly Thr Glu Gly Leu Asn Gly Gly Gly Ser His Phe 
65                  70                  75                  80  


Asp Asp Glu Cys Glu Tyr Gly Phe Thr Phe His Lys Pro Asp Asp Val 
                85                  90                  95      


Phe Lys Glu Ile Phe His Glu Arg Asp Pro Phe Ser Phe His Phe Phe 
            100                 105                 110         


Glu Asp Ser Leu Glu Asp Leu Leu Asn Arg Pro Gly Ser Ser Tyr Gly 
        115                 120                 125             


Asn Arg Asn Arg Asp Ala Gly Tyr Phe Phe Ser Thr Ala Ser Glu Tyr 
    130                 135                 140                 


Pro Ile Phe Glu Lys Phe Ser Ser Tyr Asp Thr Gly Tyr Thr Ser Gln 
145                 150                 155                 160 


Gly Ser Leu Gly His Glu Gly Leu Thr Ser Phe Ser Ser Leu Ala Phe 
                165                 170                 175     


Asp Asn Ser Gly Met Asp Asn Tyr Ile Ser Val Thr Thr Ser Asp Lys 
            180                 185                 190         


Ile Val Asn Gly Arg Asn Ile Asn Thr Lys Lys Ile Ile Glu Ser Asp 
        195                 200                 205             


Gln Glu Arg Glu Ala Glu Asp Asn Gly Glu Leu Thr Phe Phe Leu Val 
    210                 215                 220                 


Asn Ser Val Ala Asn Glu Glu Gly Phe Ala Lys Glu Cys Ser Trp Arg 
225                 230                 235                 240 


Thr Gln Ser Phe Asn Asn Tyr Ser Pro Asn Ser His Ser Ser Lys His 
                245                 250                 255     


Val Ser Gln Tyr Thr Phe Val Asp Asn Asp Glu Gly Gly Ile Ser Trp 
            260                 265                 270         


Val Thr Ser Asn Arg Asp Pro Pro Ile Phe Ser Ala Gly Val Lys Glu 
        275                 280                 285             


Gly Gly Lys Arg Lys Lys Lys Lys Arg Lys Glu Val Gln Lys Lys Ser 
    290                 295                 300                 


Thr Lys Arg Asn Cys 
305                 


<210>  8389
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB7__Homo_sapiens__AAI12136

<400>  8389
augguggauu acuaugaagu ucuaggacug caaagauaug cuucaccuga ggacauuaaa       60

aaagcuuauc auaaaguggc acuuaaaugg cacccugaua aaaauccaga aaauaaagaa      120

gaagcagaga gaaaauucaa agaaguagcu gaggcauacg agguauuauc aaaugaugag      180

aaacgggaca uuuaugauaa auauggcaca gaaggauuaa acggaggugg aagucauuuu      240

gaugaugaau gugaguacgg cuucacauuc cauaagccag augauguuuu uaaagaaauu      300

uuucaugaaa gggauccauu uucuuuucac uucuuugaag acucgcuuga ggaccuguua      360

aaucguccag gaagcuccua uggaaacaga aacagagaug caggauacuu uuucuccacu      420

gccagugaau auccaauuuu ugagaaauuu ucuucauaug auacaggaua uacaucacag      480

gguucauugg ggcaugaagg ccuuacuucu uucucuuccc uggcuuuuga uaauaguggg      540

auggacaacu acauaucugu uacaacuuca gacaaaaucg uuaauggcag aaauauuaau      600

acaaagaaaa uuauugaaag ugaucaagaa agagaagcug aagauaaugg agaguugaca      660

uuuuuucuug uaaauagugu ggccaaugaa gagggcuuug caaaagaaug cagcuggaga      720

acacagucau ucaacaacua uucaccaaau ucucacagcu ccaaacaugu aucucaauau      780

acuuucgugg acaaugauga gggagguaua ucuuggguua ccagcaacag agaucccccu      840

auuuucucag caggagucaa agaggguggu aagaggaaaa aaaagaagcg uaaagaggug      900

caaaagaagu cuaccaaaag gaauuguuaa                                       930


<210>  8390
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB7__Homo_sapiens__AAI12136

<400>  8390
augguggacu acuacgaggu ccugggccuc cagcgcuacg ccagccccga ggacaucaag       60

aaggccuacc acaagguggc gcugaagugg cacccggaca agaaccccga gaacaaggag      120

gaggccgagc ggaaguucaa ggagguggcc gaggccuacg agguccugag caacgacgag      180

aagcgcgaca ucuacgacaa guacgggacc gagggccuca acgggggcgg gagccacuuc      240

gacgacgagu gcgaguacgg cuucaccuuc cacaagcccg acgacguguu caaggagauc      300

uuccacgagc gggaccccuu cuccuuccac uucuucgagg acagccugga ggaccugcuc      360

aaccgcccgg gcuccagcua cgggaaccgg aaccgcgacg ccggcuacuu cuucuccacg      420

gcgagcgagu accccaucuu cgagaaguuc uccagcuacg acaccgggua caccucccag      480

ggcagccugg ggcacgaggg ccugaccucc uucagcuccc ucgccuucga caacagcggc      540

auggacaacu acaucuccgu gacgaccagc gacaagaucg ucaacgggcg gaacaucaac      600

accaagaaga ucaucgaguc cgaccaggag cgcgaggccg aggacaacgg cgagcugacc      660

uucuuccugg ugaacagcgu ggccaacgag gagggguucg cgaaggagug cagcuggcgg      720

acgcaguccu ucaacaacua cagccccaac ucccacagcu ccaagcacgu cagccaguac      780

accuucgugg acaacgacga gggcggcauc uccuggguga ccagcaaccg cgacccgccc      840

aucuucuccg ccggggucaa ggagggcggg aagcggaaga agaagaagcg caaggaggug      900

cagaagaagu ccaccaagcg gaacugcuga                                       930


<210>  8391
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB7__Homo_sapiens__AAI12136

<400>  8391
auggucgacu acuacgaggu ccucggccuc cagcgcuacg ccucccccga ggacaucaag       60

aaggccuacc acaaggucgc ccucaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgagc gcaaguucaa ggaggucgcc gaggccuacg agguccucuc caacgacgag      180

aagcgcgaca ucuacgacaa guacggcacc gagggccuca acggcggcgg cucccacuuc      240

gacgacgagu gcgaguacgg cuucaccuuc cacaagcccg acgacgucuu caaggagauc      300

uuccacgagc gcgaccccuu cuccuuccac uucuucgagg acucccucga ggaccuccuc      360

aaccgccccg gcuccuccua cggcaaccgc aaccgcgacg ccggcuacuu cuucuccacc      420

gccuccgagu accccaucuu cgagaaguuc uccuccuacg acaccggcua caccucccag      480

ggcucccucg gccacgaggg ccucaccucc uucuccuccc ucgccuucga caacuccggc      540

auggacaacu acaucuccgu caccaccucc gacaagaucg ucaacggccg caacaucaac      600

accaagaaga ucaucgaguc cgaccaggag cgcgaggccg aggacaacgg cgagcucacc      660

uucuuccucg ucaacuccgu cgccaacgag gagggcuucg ccaaggagug cuccuggcgc      720

acccaguccu ucaacaacua cucccccaac ucccacuccu ccaagcacgu cucccaguac      780

accuucgucg acaacgacga gggcggcauc uccuggguca ccuccaaccg cgaccccccc      840

aucuucuccg ccggcgucaa ggagggcggc aagcgcaaga agaagaagcg caaggagguc      900

cagaagaagu ccaccaagcg caacugcuga                                       930


<210>  8392
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB7__Homo_sapiens__AAI12136

<400>  8392
augguggacu acuaugaggu ccugggccuc cagagauacg ccagccccga agauaucaag       60

aaggcuuauc acaaaguugc acuuaaaugg cauccugaca agaacccaga gaauaaagaa      120

gaggccgaaa ggaaguucaa ggagguggcg gaggcuuacg aaguacuguc caacgaugag      180

aaacgggaca uuuaugauaa guacgggacc gaaggauuga augguggcgg gucucacuuu      240

gacgaugagu gcgaguaugg auucacauuu cauaaaccgg acgauguguu caaggaaaua      300

uuucacgagc gcgaccccuu cucauuucau uucuuugaag auaguuuaga ggaccugcua      360

aaccgaccug gcagcuccua cgguaaucgu aacagagaug ccggguacuu cuuuucuacu      420

gcaucggaau auccaaucuu cgagaaauuu ucaagcuacg acacgggaua uaccagucaa      480

ggcucccucg gccacgaggg gcugacaucu uucagcuccc uugccuucga caauucagga      540

auggauaacu acauuagugu cacuaccagc gacaagaucg ugaaugguag gaacauuaau      600

acaaagaaaa ucauagaauc ugaucaggag cgggaagcug aggacaacgg cgaacugacc      660

uuuuucuugg uuaauuccgu ggcaaacgag gagggguuug ccaaggaaug uucauggcgc      720

acucagagcu ucaauaacua uagucccaac ucucacucca gcaaacaugu cucgcaguac      780

acauuugugg auaaugacga gggaggcauc ucuuggguaa ccuccaacag agauccucca      840

auuuucucag cugguguuaa ggaaggggga aaaaggaaga aaaagaagcg gaaagaggug      900

caaaagaaaa guacgaagcg caauugcuga                                       930


<210>  8393
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB7__Homo_sapiens__AAI12136

<400>  8393
augguggacu acuacgaggu gcugggccug cagagauacg ccagccccga ggacaucaag       60

aaggccuacc acaagguggc ccugaagugg caccccgaca agaaccccga gaacaaggag      120

gaggccgaga gaaaguucaa ggagguggcc gaggccuacg aggugcugag caacgacgag      180

aagagagaca ucuacgacaa guacggcacc gagggccuga acggcggcgg cagccacuuc      240

gacgacgagu gcgaguacgg cuucaccuuc cacaagcccg acgacguguu caaggagauc      300

uuccacgaga gagaccccuu cagcuuccac uucuucgagg acagccugga ggaccugcug      360

aacagacccg gcagcagcua cggcaacaga aacagagacg ccggcuacuu cuucagcacc      420

gccagcgagu accccaucuu cgagaaguuc agcagcuacg acaccggcua caccagccag      480

ggcagccugg gccacgaggg ccugaccagc uucagcagcc uggccuucga caacagcggc      540

auggacaacu acaucagcgu gaccaccagc gacaagaucg ugaacggcag aaacaucaac      600

accaagaaga ucaucgagag cgaccaggag agagaggccg aggacaacgg cgagcugacc      660

uucuuccugg ugaacagcgu ggccaacgag gagggcuucg ccaaggagug cagcuggaga      720

acccagagcu ucaacaacua cagccccaac agccacagca gcaagcacgu gagccaguac      780

accuucgugg acaacgacga gggcggcauc agcuggguga ccagcaacag agaccccccc      840

aucuucagcg ccggcgugaa ggagggcggc aagagaaaga agaagaagag aaaggaggug      900

cagaagaaga gcaccaagag aaacugcuga                                       930


<210>  8394
<211>  930
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB7__Homo_sapiens__AAI12136

<400>  8394
augguggacu acuaugaggu ccugggccuc cagagauacg ccagccccga agauaucaag       60

aaggcuuauc acaaaguugc ccugaaaugg cauccugaca agaacccgga gaauaaagaa      120

gaggcggaac ggaaguucaa ggagguggcu gaggccuacg aagugcuuuc caacgaugag      180

aaacgcgaca uuuaugauaa guacgggacc gaaggacuga auggcggggg aucucacuuu      240

gacgaugagu gcgaguaugg cuucacauuu cauaaacccg acgaugucuu caaggaaauc      300

uuucacgaga gagacccuuu cagcuuucau uucuuugaag auucccucga ggaccugcuu      360

aaccggcccg ggucuagcua cggaaaucgc aacagagaug ccggcuacuu cuuuuccacg      420

gcuucugaau auccuauuuu cgagaaauuu agcuccuacg acaccggcua uacaagccaa      480

gggucucugg gacacgaggg ccucaccucc uucagcucuc uggccuucga caauuccggg      540

auggauaacu acaucagcgu gacaaccucu gacaagauug uuaauggacg gaacaucaau      600

acaaagaaaa ucauugaauc cgaucaggag cgcgaagcug aggacaacgg cgaacugacc      660

uuuuuccucg ugaauagcgu cgccaacgag gagggguuug cgaaggaaug uuccuggaga      720

acgcagucuu ucaauaacua uagccccaac ucccacagcu cuaaacaugu gucccaguac      780

accuuuguug auaaugacga gggaggcauc agcuggguga caucuaaccg ggauccuccg      840

auuuucagcg ccggcgucaa ggaaggggga aaacgcaaga aaaagaagag aaaagaggug      900

caaaagaaau ccaccaagcg gaauugcuga                                       930


<210>  8395
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB8__Homo_sapiens__Q8NHS0

<400>  8395

Met Ala Asn Tyr Tyr Glu Val Leu Gly Val Gln Ala Ser Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Arg Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Asp Asn Lys Glu Glu Ala Glu Lys Lys Phe Lys Leu 
        35                  40                  45              


Val Ser Glu Ala Tyr Glu Val Leu Ser Asp Ser Lys Lys Arg Ser Leu 
    50                  55                  60                  


Tyr Asp Arg Ala Gly Cys Asp Ser Trp Arg Ala Gly Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Pro Tyr His Ser Pro Phe Asp Thr Gly Tyr Thr Phe Arg Asn Pro 
                85                  90                  95      


Glu Asp Ile Phe Arg Glu Phe Phe Gly Gly Leu Asp Pro Phe Ser Phe 
            100                 105                 110         


Glu Phe Trp Asp Ser Pro Phe Asn Ser Asp Arg Gly Gly Arg Gly His 
        115                 120                 125             


Gly Leu Arg Gly Ala Phe Ser Ala Gly Phe Gly Glu Phe Pro Ala Phe 
    130                 135                 140                 


Met Glu Ala Phe Ser Ser Phe Asn Met Leu Gly Cys Ser Gly Gly Ser 
145                 150                 155                 160 


His Thr Thr Phe Ser Ser Thr Ser Phe Gly Gly Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Gly Phe Lys Ser Val Met Ser Ser Thr Glu Met Ile Asn Gly His 
            180                 185                 190         


Lys Val Thr Thr Lys Arg Ile Val Glu Asn Gly Gln Glu Arg Val Glu 
        195                 200                 205             


Val Glu Glu Asp Gly Gln Leu Lys Ser Val Thr Val Asn Gly Lys Glu 
    210                 215                 220                 


Gln Leu Lys Trp Met Asp Ser Lys 
225                 230         


<210>  8396
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB8__Homo_sapiens__AAH29521

<400>  8396
auggcuaacu acuacgaagu gcugggcgug caggccagcg cuuccccgga ggacaucaag       60

aaagccuacc gcaagcuggc ccuucguugg caccccgaca agaacccuga caauaaggag      120

gaggcggaga agaaguucaa gcuggugucu gaggccuaug agguucuguc ugacuccaag      180

aaacgcuccc uguaugaccg ugcuggcugu gacagcuggc gggcuggugg cggggccagc      240

acgcccuacc acagccccuu cgacaccggc uacaccuucc guaacccuga ggacaucuuc      300

cgggaguuuu ucgguggccu ggacccuuuc uccuuugagu ucugggacag cccauucaau      360

agugaccgug guggccgggg ccauggccug aggggggccu ucucggcagg cuuuggagaa      420

uuuccggccu ucauggaggc cuucucaucc uucaacaugc ugggcugcag cgggggcagc      480

cacaccaccu ucucauccac cuccuucggg ggcuccaguu cuggcagcuc gggguucaag      540

ucggugaugu cguccaccga gaugaucaau ggccacaagg ucaccaccaa gcgcaucgug      600

gagaacgggc aggagcgcgu ggagguggag gaagacgggc agcucaaguc ggugacugug      660

aacggcaagg agcagcucaa auggauggac agcaaguag                             699


<210>  8397
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB8__Homo_sapiens__AAH29521

<400>  8397
auggccaacu acuacgaggu gcugggcguc caggccagcg cgucccccga ggacaucaag       60

aaggccuacc gcaagcucgc ccugcggugg cacccggaca agaaccccga caacaaggag      120

gaggccgaga agaaguucaa gcuggugagc gaggccuacg aggugcucuc cgacagcaag      180

aagcgcuccc uguacgaccg ggcggggugc gacagcuggc gcgccggcgg gggcgccucc      240

acccccuacc acagccccuu cgacaccggg uacacguucc ggaacccgga ggacaucuuc      300

cgcgaguucu ucggcggccu ggaccccuuc uccuucgagu ucugggacag ccccuucaac      360

uccgaccgcg ggggccgggg gcacggccuc cgcggggccu ucagcgcggg cuucggcgag      420

uuccccgccu ucauggaggc cuucuccagc uucaacaugc uggggugcuc cggcgggagc      480

cacaccaccu ucuccagcac cuccuucggc ggcagcagcu ccgggagcuc cggcuucaag      540

agcgucaugu ccagcacgga gaugaucaac gggcacaagg ugaccaccaa gcggaucgug      600

gagaacggcc aggagcgggu cgagguggag gaggacgggc agcugaaguc cgugaccguc      660

aacggcaagg agcagcucaa guggauggac agcaaguga                             699


<210>  8398
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB8__Homo_sapiens__AAH29521

<400>  8398
auggccaacu acuacgaggu ccucggcguc caggccuccg ccucccccga ggacaucaag       60

aaggccuacc gcaagcucgc ccuccgcugg caccccgaca agaaccccga caacaaggag      120

gaggccgaga agaaguucaa gcucgucucc gaggccuacg agguccucuc cgacuccaag      180

aagcgcuccc ucuacgaccg cgccggcugc gacuccuggc gcgccggcgg cggcgccucc      240

acccccuacc acucccccuu cgacaccggc uacaccuucc gcaaccccga ggacaucuuc      300

cgcgaguucu ucggcggccu cgaccccuuc uccuucgagu ucugggacuc ccccuucaac      360

uccgaccgcg gcggccgcgg ccacggccuc cgcggcgccu ucuccgccgg cuucggcgag      420

uuccccgccu ucauggaggc cuucuccucc uucaacaugc ucggcugcuc cggcggcucc      480

cacaccaccu ucuccuccac cuccuucggc ggcuccuccu ccggcuccuc cggcuucaag      540

uccgucaugu ccuccaccga gaugaucaac ggccacaagg ucaccaccaa gcgcaucguc      600

gagaacggcc aggagcgcgu cgaggucgag gaggacggcc agcucaaguc cgucaccguc      660

aacggcaagg agcagcucaa guggauggac uccaaguga                             699


<210>  8399
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB8__Homo_sapiens__AAH29521

<400>  8399
auggccaacu acuaugaggu gcugggcguc caggcuagcg caucccccga agacaucaag       60

aaagccuaca gaaagcucgc gcuuaggugg cacccugaua aaaauccaga caacaaggag      120

gaagcugaga aaaaguucaa gcugguuucu gaagccuaug agguguuguc agauaguaaa      180

aagcggagcu uauacgaccg cgcagggugc gauuccuggc gagccggagg uggcgcuucu      240

accccguauc auucgcccuu ugacacaggg uacacuuucc guaauccuga ggauauuuuu      300

agagaauuuu ucggaggccu ggacccauuc ucauuugagu ucugggauag ccccuuuaac      360

agugacaggg gugggcgggg acacggccua cgcggcgcau ucuccgccgg guuuggagag      420

uucccugcuu uuauggaagc cuucucuagc uucaauaugc ucgguuguuc cggcggguca      480

cauacgaccu uuaguagcac aucuuucgga ggcuccucaa gcgguaguuc uggguuuaaa      540

uccguaauga gcucgacuga gaugauaaac ggacacaagg ugaccacaaa aagaaucguc      600

gaaaauggcc aagagagggu ggaaguugag gaagauggcc agcugaaguc ugugaccguc      660

aacgggaagg agcagcuuaa auggauggac uccaaguga                             699


<210>  8400
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB8__Homo_sapiens__AAH29521

<400>  8400
auggccaacu acuacgaggu gcugggcgug caggccagcg ccagccccga ggacaucaag       60

aaggccuaca gaaagcuggc ccugagaugg caccccgaca agaaccccga caacaaggag      120

gaggccgaga agaaguucaa gcuggugagc gaggccuacg aggugcugag cgacagcaag      180

aagagaagcc uguacgacag agccggcugc gacagcugga gagccggcgg cggcgccagc      240

acccccuacc acagccccuu cgacaccggc uacaccuuca gaaaccccga ggacaucuuc      300

agagaguucu ucggcggccu ggaccccuuc agcuucgagu ucugggacag ccccuucaac      360

agcgacagag gcggcagagg ccacggccug agaggcgccu ucagcgccgg cuucggcgag      420

uuccccgccu ucauggaggc cuucagcagc uucaacaugc ugggcugcag cggcggcagc      480

cacaccaccu ucagcagcac cagcuucggc ggcagcagca gcggcagcag cggcuucaag      540

agcgugauga gcagcaccga gaugaucaac ggccacaagg ugaccaccaa gagaaucgug      600

gagaacggcc aggagagagu ggagguggag gaggacggcc agcugaagag cgugaccgug      660

aacggcaagg agcagcugaa guggauggac agcaaguga                             699


<210>  8401
<211>  699
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB8__Homo_sapiens__AAH29521

<400>  8401
auggccaacu acuaugaggu gcugggcguc caggcuagcg ccucccccga agacaucaag       60

aaagcguaca gaaagcucgc ucugcggugg cacccugaua aaaauccgga caacaaggag      120

gaagccgaga aaaaguucaa acuuguuucu gaagccuaug aggugcugag cgauuccaag      180

aagcgcucuc ucuacgacag agcugggugc gauagcuggc gggccggagg cggggcuucc      240

acccccuauc auucuccuuu ugacacagga uacacguucc gcaaucccga ggauauuuuu      300

agagaauuuu ucggcgggcu ggacccuuuc agcuuugagu ucugggauuc ccccuuuaac      360

agcgaccggg gaggccgcgg ccacgggcuu agaggagccu ucucugcggg cuuuggggaa      420

uuuccugccu ucauggaggc uuucuccagc uucaauaugc ugggauguuc uggcgggucc      480

cauaccacau uuagcucuac cuccuucgga ggcagcuccu cuggcagcuc cggguuuaaa      540

agcgugaugu cuuccacaga gaugaucaac ggacacaagg ucaccacaaa acggauugug      600

gaaaauggcc aagagcgcgu ugaaguggag gaagaugggc agcucaagag cgucaccgug      660

aacggaaagg agcagcugaa auggauggac ucuaaguga                             699


<210>  8402
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJB9__Homo_sapiens__Q9UBS3

<400>  8402

Met Ala Thr Pro Gln Ser Ile Phe Ile Phe Ala Ile Cys Ile Leu Met 
1               5                   10                  15      


Ile Thr Glu Leu Ile Leu Ala Ser Lys Ser Tyr Tyr Asp Ile Leu Gly 
            20                  25                  30          


Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
        35                  40                  45              


Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
    50                  55                  60                  


Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
65                  70                  75                  80  


Asn Arg Arg Lys Glu Tyr Asp Thr Leu Gly His Ser Ala Phe Thr Ser 
                85                  90                  95      


Gly Lys Gly Gln Arg Gly Ser Gly Ser Ser Phe Glu Gln Ser Phe Asn 
            100                 105                 110         


Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Gly Phe Phe Gly Gln Asn 
        115                 120                 125             


Gln Asn Thr Gly Ser Lys Lys Arg Phe Glu Asn His Phe Gln Thr Arg 
    130                 135                 140                 


Gln Asp Gly Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser 
145                 150                 155                 160 


Phe Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met 
                165                 170                 175     


Phe Ser Phe Ser Gly Phe Asp Ser Thr Asn Gln His Thr Val Gln Thr 
            180                 185                 190         


Glu Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln 
        195                 200                 205             


Arg Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
    210                 215                 220             


<210>  8403
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJB9__Homo_sapiens__AAD39845

<400>  8403
auggcuacuc cccagucaau uuucaucuuu gcaaucugca uuuuaaugau aacagaauua       60

auucuggccu caaaaagcua cuaugauauc uuaggugugc caaaaucggc aucagagcgc      120

caaaucaaga aggccuuuca caaguuggcc augaaguacc acccugacaa aaauaagagc      180

ccggaugcug aagcaaaauu cagagagauu gcagaagcau augaaacacu cucagaugcu      240

aauagacgaa aagaguauga uacacuugga cacagugcuu uuacuagugg uaaaggacaa      300

agagguagug gaaguucuuu ugagcaguca uuuaacuuca auuuugauga cuuauuuaaa      360

gacuuuggcu uuuuugguca aaaccaaaac acuggaucca agaagcguuu ugaaaaucau      420

uuccagacac gccaggaugg ugguuccagu agacaaaggc aucauuucca agaauuuucu      480

uuuggaggug gauuauuuga ugacauguuu gaagauaugg agaaaauguu uucuuuuagu      540

gguuuugacu cuaccaauca gcauacagua cagacugaaa auagauuuca uggaucuagc      600

aagcacugca ggacugucac ucaacgaaga ggaaauaugg uuacuacaua cacugacugu      660

ucaggacagu ag                                                          672


<210>  8404
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJB9__Homo_sapiens__AAD39845

<400>  8404
auggccacgc cccagagcau cuucaucuuc gccaucugca uccugaugau caccgagcuc       60

auccuggcgu ccaagagcua cuacgacauc cugggcgugc cgaaguccgc cagcgagcgc      120

cagaucaaga aggccuucca caagcucgcc augaaguacc accccgacaa gaacaagucc      180

cccgacgccg aggcgaaguu ccgggagauc gccgaggccu acgagacccu gagcgacgcc      240

aaccgccgga aggaguacga cacccugggg cacuccgcgu ucaccagcgg caaggggcag      300

cgcggcuccg ggagcuccuu cgagcagagc uucaacuuca acuucgacga ccucuucaag      360

gacuucggcu ucuucggcca gaaccagaac accgggucca agaagcgguu cgagaaccac      420

uuccagacgc gccaggacgg cgggagcucc cggcagcgcc accacuucca ggaguucagc      480

uucggcgggg gccuguucga cgacauguuc gaggacaugg agaagauguu cuccuucagc      540

ggcuucgacu ccaccaacca gcacaccguc cagaccgaga accgguucca cgggagcagc      600

aagcacugcc gcacggugac ccagcggcgc ggcaacaugg ugaccaccua cacggacugc      660

uccgggcagu ga                                                          672


<210>  8405
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJB9__Homo_sapiens__AAD39845

<400>  8405
auggccaccc cccaguccau cuucaucuuc gccaucugca uccucaugau caccgagcuc       60

auccucgccu ccaaguccua cuacgacauc cucggcgucc ccaaguccgc cuccgagcgc      120

cagaucaaga aggccuucca caagcucgcc augaaguacc accccgacaa gaacaagucc      180

cccgacgccg aggccaaguu ccgcgagauc gccgaggccu acgagacccu cuccgacgcc      240

aaccgccgca aggaguacga cacccucggc cacuccgccu ucaccuccgg caagggccag      300

cgcggcuccg gcuccuccuu cgagcagucc uucaacuuca acuucgacga ccucuucaag      360

gacuucggcu ucuucggcca gaaccagaac accggcucca agaagcgcuu cgagaaccac      420

uuccagaccc gccaggacgg cggcuccucc cgccagcgcc accacuucca ggaguucucc      480

uucggcggcg gccucuucga cgacauguuc gaggacaugg agaagauguu cuccuucucc      540

ggcuucgacu ccaccaacca gcacaccguc cagaccgaga accgcuucca cggcuccucc      600

aagcacugcc gcaccgucac ccagcgccgc ggcaacaugg ucaccaccua caccgacugc      660

uccggccagu ga                                                          672


<210>  8406
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJB9__Homo_sapiens__AAD39845

<400>  8406
auggccacac cccagagcau cuucauuuuu gcuauaugca uccugaugau uaccgagcuc       60

auccuugcau ccaagucuua cuaugacauu cugggcgugc cuaaaucagc cagugaaaga      120

caaaucaaga aagcguucca caaguuggcu augaaauacc auccagauaa gaacaagagc      180

ccggacgccg aggcaaaauu uagggaaaua gccgaggcuu augaaacuuu auccgaugca      240

aaucggcgca aggaguacga cacgcugggg cacucugccu ucaccucggg aaaaggucag      300

cgaggcucag ggagcaguuu ugagcagucc uucaacuuua auuucgauga ccuauuuaag      360

gauuucggau uuuucggcca gaaccaaaau acagguucua aaaagcguuu ugaaaaccau      420

uuccagacua gacaggacgg gggaagcucc aggcagcggc accauuucca agaguuuuca      480

uucggcggcg ggcucuuuga ugacauguuc gaagauaugg agaagauguu uaguuucagc      540

ggauuugacu cuaccaauca gcacacaguc cagaccgaga accgcuucca cgguuccuca      600

aaacauugua gaacuguuac acagaggcgg ggcaauaugg ugaccacgua uacugauugc      660

agcgggcaau ga                                                          672


<210>  8407
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJB9__Homo_sapiens__AAD39845

<400>  8407
auggccaccc cccagagcau cuucaucuuc gccaucugca uccugaugau caccgagcug       60

auccuggcca gcaagagcua cuacgacauc cugggcgugc ccaagagcgc cagcgagaga      120

cagaucaaga aggccuucca caagcuggcc augaaguacc accccgacaa gaacaagagc      180

cccgacgccg aggccaaguu cagagagauc gccgaggccu acgagacccu gagcgacgcc      240

aacagaagaa aggaguacga cacccugggc cacagcgccu ucaccagcgg caagggccag      300

agaggcagcg gcagcagcuu cgagcagagc uucaacuuca acuucgacga ccuguucaag      360

gacuucggcu ucuucggcca gaaccagaac accggcagca agaagagauu cgagaaccac      420

uuccagacca gacaggacgg cggcagcagc agacagagac accacuucca ggaguucagc      480

uucggcggcg gccuguucga cgacauguuc gaggacaugg agaagauguu cagcuucagc      540

ggcuucgaca gcaccaacca gcacaccgug cagaccgaga acagauucca cggcagcagc      600

aagcacugca gaaccgugac ccagagaaga ggcaacaugg ugaccaccua caccgacugc      660

agcggccagu ga                                                          672


<210>  8408
<211>  672
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJB9__Homo_sapiens__AAD39845

<400>  8408
auggccacac cccagagcau cuucauuuuu gcuaucugca uucugaugau caccgagcuc       60

auucuggccu ccaagucuua cuaugacauc cuuggcgugc cuaaaagcgc guccgaaaga      120

caaaucaaga aggcuuucca caaacuggcc augaaauacc auccggauaa gaacaagucu      180

cccgacgccg aggcuaaauu ucgggaaauu gccgaggcuu augaaacgcu cagcgaugcc      240

aaucgcagaa aggaguacga cacccugggg cacuccgcgu ucacaucugg aaaaggccag      300

cgggggagcg gauccagcuu ugagcagucu uucaacuuua auuucgauga ccuuuuuaag      360

gauuucggcu uuuucgggca gaaccaaaau accggaucca aaaagcgcuu ugaaaaccau      420

uuccagacaa gacaggacgg cggcagcucu cggcagcgcc accauuucca agaguuuucc      480

uucgggggag gccuguuuga ugacauguuc gaagauaugg agaagauguu uagcuucucu      540

ggguuugacu ccaccaauca gcacacaguc cagaccgaga acagauucca cggaagcucc      600

aaacauuguc ggacgguuac ccagcgcaga ggcaauaugg ugacaaccua uacagauugc      660

ucugggcaau ga                                                          672


<210>  8409
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC1__Homo_sapiens__Q96KC8

<400>  8409

Met Thr Ala Pro Cys Ser Gln Pro Ala Gln Leu Pro Gly Arg Arg Gln 
1               5                   10                  15      


Leu Gly Leu Val Pro Phe Pro Pro Pro Pro Pro Arg Thr Pro Leu Leu 
            20                  25                  30          


Trp Leu Leu Leu Leu Leu Leu Ala Ala Val Ala Pro Ala Arg Gly Trp 
        35                  40                  45              


Glu Ser Gly Asp Leu Glu Leu Phe Asp Leu Val Glu Glu Val Gln Leu 
    50                  55                  60                  


Asn Phe Tyr Gln Phe Leu Gly Val Gln Gln Asp Ala Ser Ser Ala Asp 
65                  70                  75                  80  


Ile Arg Lys Ala Tyr Arg Lys Leu Ser Leu Thr Leu His Pro Asp Lys 
                85                  90                  95      


Asn Lys Asp Glu Asn Ala Glu Thr Gln Phe Arg Gln Leu Val Ala Ile 
            100                 105                 110         


Tyr Glu Val Leu Lys Asp Asp Glu Arg Arg Gln Arg Tyr Asp Asp Ile 
        115                 120                 125             


Leu Ile Asn Gly Leu Pro Asp Trp Arg Gln Pro Val Phe Tyr Tyr Arg 
    130                 135                 140                 


Arg Val Arg Lys Met Ser Asn Ala Glu Leu Ala Leu Leu Leu Phe Ile 
145                 150                 155                 160 


Ile Leu Thr Val Gly His Tyr Ala Val Val Trp Ser Ile Tyr Leu Glu 
                165                 170                 175     


Lys Gln Leu Asp Glu Leu Leu Ser Arg Lys Lys Arg Glu Lys Lys Lys 
            180                 185                 190         


Lys Thr Gly Ser Lys Ser Val Asp Val Ser Lys Leu Gly Ala Ser Glu 
        195                 200                 205             


Lys Asn Glu Arg Leu Leu Met Lys Pro Gln Trp His Asp Leu Leu Pro 
    210                 215                 220                 


Cys Lys Leu Gly Ile Trp Phe Cys Leu Thr Leu Lys Ala Leu Pro His 
225                 230                 235                 240 


Leu Ile Gln Asp Ala Gly Gln Phe Tyr Ala Lys Tyr Lys Glu Thr Arg 
                245                 250                 255     


Leu Lys Glu Lys Glu Asp Ala Leu Thr Arg Thr Glu Leu Glu Thr Leu 
            260                 265                 270         


Gln Lys Gln Lys Lys Val Lys Lys Pro Lys Pro Glu Phe Pro Val Tyr 
        275                 280                 285             


Thr Pro Leu Glu Thr Thr Tyr Ile Gln Ser Tyr Asp His Gly Thr Ser 
    290                 295                 300                 


Ile Glu Glu Ile Glu Glu Gln Met Asp Asp Trp Leu Glu Asn Arg Asn 
305                 310                 315                 320 


Arg Thr Gln Lys Lys Gln Ala Pro Glu Trp Thr Glu Glu Asp Leu Ser 
                325                 330                 335     


Gln Leu Thr Arg Ser Met Val Lys Phe Pro Gly Gly Thr Pro Gly Arg 
            340                 345                 350         


Trp Glu Lys Ile Ala His Glu Leu Gly Arg Ser Val Thr Asp Val Thr 
        355                 360                 365             


Thr Lys Ala Lys Gln Leu Lys Asp Ser Val Thr Cys Ser Pro Gly Met 
    370                 375                 380                 


Val Arg Leu Ser Glu Leu Lys Ser Thr Val Gln Asn Ser Arg Pro Ile 
385                 390                 395                 400 


Lys Thr Ala Thr Thr Leu Pro Asp Asp Met Ile Thr Gln Arg Glu Asp 
                405                 410                 415     


Ala Glu Gly Val Ala Ala Glu Glu Glu Gln Glu Gly Asp Ser Gly Glu 
            420                 425                 430         


Gln Glu Thr Gly Ala Thr Asp Ala Arg Pro Arg Arg Arg Lys Pro Ala 
        435                 440                 445             


Arg Leu Leu Glu Ala Thr Ala Lys Pro Glu Pro Glu Glu Lys Ser Arg 
    450                 455                 460                 


Ala Lys Arg Gln Lys Asp Phe Asp Ile Ala Glu Gln Asn Glu Ser Ser 
465                 470                 475                 480 


Asp Glu Glu Ser Leu Arg Lys Glu Arg Ala Arg Ser Ala Glu Glu Pro 
                485                 490                 495     


Trp Thr Gln Asn Gln Gln Lys Leu Leu Glu Leu Ala Leu Gln Gln Tyr 
            500                 505                 510         


Pro Arg Gly Ser Ser Asp Arg Trp Asp Lys Ile Ala Arg Cys Val Pro 
        515                 520                 525             


Ser Lys Ser Lys Glu Asp Cys Ile Ala Arg Tyr Lys Leu Leu Val Glu 
    530                 535                 540                 


Leu Val Gln Lys Lys Lys Gln Ala Lys Ser 
545                 550                 


<210>  8410
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC1__Homo_sapiens__AAI10895

<400>  8410
augacggcuc cuugcuccca gccggcgcag cuuccuggac gccgccagcu cgggcuggug       60

ccguucccgc cgccgccgcc gcggacgccg cugcuguggc ugcugcugcu gcugcuggcc      120

gccguggcgc cggcgcgcgg cugggagagc ggagaccugg aguuguuuga cuuaguggag      180

gaggugcagc ucaacuucua ccaguuccuc ggggugcagc aggaugcauc aucugcagac      240

aucagaaaag cauaucguaa gcuuucacua acuuuacauc cagacaagaa uaaagaugaa      300

aaugcagaaa cucaguuuag acaauuggug gccauuuaug aaguuuuaaa ggaugaugaa      360

cgaaggcaga gguaugauga uauucugauc aauggacuuc cagauuggcg acagccugua      420

uucuacuaca ggcgggugag aaaaaugagc aaugcugagc uggcauuacu cuuguucauu      480

auucucacag ugggucauua ugcugugguu uggucaaucu accuggaaaa acaacuggau      540

gaacuacuaa guagaaaaaa gagagaaaag aaaaaaaaga cuggcagcaa gaguguggau      600

guaucaaaac ucggugcuuc agaaaaaaau gaaagauugc ugaugaaacc acaguggcau      660

gauuugcuuc caugcaaacu ggggauuugg uuuugccuua cacuaaaagc auuaccucac      720

cucauccagg augcugggca guuuuaugcu aaauauaaag aaacaagauu gaaggaaaag      780

gaagaugcac ugacuagaac ugaacuugaa acacuucaaa aacagaagaa aguuaaaaaa      840

ccaaaaccug aauuuccugu auacacaccu uuagaaacua cauauauuca gucuuaugau      900

cauggaacuu ccauagaaga aauugaggaa caaauggaug auugguugga aaacaggaac      960

cgaacacaga aaaaacaggc accugaaugg acagaagagg accucagcca acugacaaga     1020

aguaugguua aguucccagg agggacucca ggucgauggg aaaagauugc ccacgaauug     1080

ggucgaucug ugacagaugu gacaaccaaa gccaagcaac ugaaggauuc agugaccugc     1140

uccccaggaa ugguuagacu cuccgaacuc aaaucgacag uucagaauuc caggcccauc     1200

aaaacggcca ccaccuugcc cgaugacaug aucacccagc gagaggacgc agagggggug     1260

gcagcggagg aggagcagga gggagacucc ggugagcagg agaccggggc cacugaugcc     1320

cggccucgga ggcggaagcc agccaggcug cuggaggcua cagcgaagcc ggagccagag     1380

gagaagucca gagccaagcg gcagaaggac uuugacauag cagaacaaaa cgaguccagc     1440

gacgaggaga gccugagaaa agagagagcu cggucugcag aggagccgug gacucaaaau     1500

caacagaaac uucuggaacu ggcguugcag caguacccaa ggggauccuc ugaccgcugg     1560

gacaaaauag ccagaugugu cccguccaag agcaaggaag acuguaucgc uagguacaag     1620

uugcugguug aacuggucca aaagaaaaaa caagcuaaaa gcuga                     1665


<210>  8411
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC1__Homo_sapiens__AAI10895

<400>  8411
augaccgccc ccugcagcca gccggcccag cugcccggcc gccggcagcu cgggcuggug       60

cccuucccgc ccccgccgcc ccgcacgccc cugcucuggc ugcugcuccu gcugcucgcg      120

gccgucgccc ccgcccgggg cugggagucc ggggaccugg agcuguucga ccucguggag      180

gaggugcagc ugaacuucua ccaguuccug ggcguccagc aggacgccag cuccgcggac      240

auccgcaagg ccuaccggaa gcucagccug acccugcacc ccgacaagaa caaggacgag      300

aacgccgaga cccaguuccg ccagcucgug gccaucuacg aggugcugaa ggacgacgag      360

cggcgccagc gguacgacga cauccugauc aacgggcucc ccgacuggcg ccagcccguc      420

uucuacuacc ggcgcgugcg gaagaugucc aacgcggagc uggcccugcu ccuguucauc      480

auccugaccg ugggccacua cgccgucgug uggagcaucu accucgagaa gcagcuggac      540

gagcugcucu cccgcaagaa gcgggagaag aagaagaaga ccggcagcaa guccguggac      600

gucagcaagc ugggggccuc cgagaagaac gagcgccugc ucaugaagcc ccaguggcac      660

gaccugcugc ccugcaagcu cggcaucugg uucugccuga cgcugaaggc ccucccccac      720

cugauccagg acgcggggca guucuacgcc aaguacaagg agacccggcu gaaggagaag      780

gaggacgccc ucacccgcac cgagcuggag acgcugcaga agcagaagaa ggugaagaag      840

ccgaagcccg aguuccccgu guacacgccc cucgagacca ccuacaucca gagcuacgac      900

cacggcaccu ccaucgagga gaucgaggag cagauggacg acuggcugga gaaccggaac      960

cgcacccaga agaagcaggc cccggagugg accgaggagg accugagcca gcucacccgg     1020

uccaugguca aguuccccgg gggcacgccc ggccgcuggg agaagaucgc ccacgagcug     1080

gggcgcagcg ugaccgacgu gaccaccaag gcgaagcagc ugaaggacuc cgucacgugc     1140

agccccggca uggugcggcu guccgagcuc aagagcaccg ugcagaacag ccgcccgauc     1200

aagaccgcca ccacgcugcc cgacgacaug aucacccagc gggaggacgc cgaggggguc     1260

gccgccgagg aggagcagga gggcgacucc ggcgagcagg agaccggggc gaccgacgcc     1320

cgcccccggc gccggaagcc cgcccgccug cucgaggcca cggccaagcc ggagcccgag     1380

gagaaguccc gggcgaagcg ccagaaggac uucgacaucg ccgagcagaa cgagagcagc     1440

gacgaggagu cccugcggaa ggagcgcgcc cggagcgccg aggagcccug gacccagaac     1500

cagcagaagc ugcucgagcu ggcgcugcag caguacccgc gcggcuccag cgaccggugg     1560

gacaagaucg cccgcugcgu gcccuccaag agcaaggagg acugcaucgc ccgguacaag     1620

cuccuggugg agcuggucca gaagaagaag caggccaagu ccuga                     1665


<210>  8412
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC1__Homo_sapiens__AAI10895

<400>  8412
augaccgccc ccugcuccca gcccgcccag cuccccggcc gccgccagcu cggccucguc       60

cccuuccccc cccccccccc ccgcaccccc cuccucuggc uccuccuccu ccuccucgcc      120

gccgucgccc ccgcccgcgg cugggagucc ggcgaccucg agcucuucga ccucgucgag      180

gagguccagc ucaacuucua ccaguuccuc ggcguccagc aggacgccuc cuccgccgac      240

auccgcaagg ccuaccgcaa gcucucccuc acccuccacc ccgacaagaa caaggacgag      300

aacgccgaga cccaguuccg ccagcucguc gccaucuacg agguccucaa ggacgacgag      360

cgccgccagc gcuacgacga cauccucauc aacggccucc ccgacuggcg ccagcccguc      420

uucuacuacc gccgcguccg caagaugucc aacgccgagc ucgcccuccu ccucuucauc      480

auccucaccg ucggccacua cgccgucguc ugguccaucu accucgagaa gcagcucgac      540

gagcuccucu cccgcaagaa gcgcgagaag aagaagaaga ccggcuccaa guccgucgac      600

gucuccaagc ucggcgccuc cgagaagaac gagcgccucc ucaugaagcc ccaguggcac      660

gaccuccucc ccugcaagcu cggcaucugg uucugccuca cccucaaggc ccucccccac      720

cucauccagg acgccggcca guucuacgcc aaguacaagg agacccgccu caaggagaag      780

gaggacgccc ucacccgcac cgagcucgag acccuccaga agcagaagaa ggucaagaag      840

cccaagcccg aguuccccgu cuacaccccc cucgagacca ccuacaucca guccuacgac      900

cacggcaccu ccaucgagga gaucgaggag cagauggacg acuggcucga gaaccgcaac      960

cgcacccaga agaagcaggc ccccgagugg accgaggagg accucuccca gcucacccgc     1020

uccaugguca aguuccccgg cggcaccccc ggccgcuggg agaagaucgc ccacgagcuc     1080

ggccgcuccg ucaccgacgu caccaccaag gccaagcagc ucaaggacuc cgucaccugc     1140

ucccccggca ugguccgccu cuccgagcuc aaguccaccg uccagaacuc ccgccccauc     1200

aagaccgcca ccacccuccc cgacgacaug aucacccagc gcgaggacgc cgagggcguc     1260

gccgccgagg aggagcagga gggcgacucc ggcgagcagg agaccggcgc caccgacgcc     1320

cgcccccgcc gccgcaagcc cgcccgccuc cucgaggcca ccgccaagcc cgagcccgag     1380

gagaaguccc gcgccaagcg ccagaaggac uucgacaucg ccgagcagaa cgaguccucc     1440

gacgaggagu cccuccgcaa ggagcgcgcc cgcuccgccg aggagcccug gacccagaac     1500

cagcagaagc uccucgagcu cgcccuccag caguaccccc gcggcuccuc cgaccgcugg     1560

gacaagaucg cccgcugcgu ccccuccaag uccaaggagg acugcaucgc ccgcuacaag     1620

cuccucgucg agcucgucca gaagaagaag caggccaagu ccuga                     1665


<210>  8413
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC1__Homo_sapiens__AAI10895

<400>  8413
augaccgccc ccugcagcca gccugcucaa cugccaggca gaaggcagcu cgggcuugug       60

ccguuucccc cuccaccccc ucggacacca cuguuguggu uacugcuacu ccugcuugca      120

gccgucgcgc ccgcucgcgg augggagucc ggugaccugg aauuguucga ucucguugag      180

gaagugcagc ugaacuucua ccaguuucug ggcguacaac aggacgccuc uucagcagau      240

auccgaaagg ccuaucguaa acucaguuua acucugcacc cugacaagaa uaaagaugag      300

aacgcugaaa cgcaguucag acagcuugug gcaauuuacg aggucuugaa ggacgaugag      360

aggcggcaac gcuaugacga uauacugauc aaugggcuac cagacuggag acagccggug      420

uuuuacuaua ggcggguucg caaaaugagc aacgccgaac ucgcucugcu ucuguucauu      480

aucuugaccg ugggacauua cgccgucgug ugguccauuu aucucgagaa gcagcuggau      540

gaauuacugu cucgaaagaa aagagagaag aaaaagaaaa caggcucgaa gucaguagac      600

guuagcaagc ucggugcgag ugagaaaaau gaaaggcuuc ugaugaagcc ccaguggcac      660

gauuugcuac cuuguaaacu ggggaucugg uuuugccuca cucugaaggc acuuccacau      720

cugauacaag acgccggaca guucuacgcu aaauacaagg agacccgguu gaaagaaaag      780

gaggacgccc ucacacguac cgaacuggag acuuuacaga agcagaaaaa ggugaaaaag      840

cccaaaccug aguuuccagu cuauacaccc cuggaaacca cguacaucca auccuaugau      900

cacggcacuu cuauugagga aaucgaggaa cagauggacg auuggcuaga gaaccgcaau      960

agaacccaga agaagcaagc accggagugg acagaagagg accucagcca gcugacuagg     1020

uccaugguga aauucccugg cgggaccccc ggacgguggg aaaagauugc ucaugagcuu     1080

ggucgaucag ugacagaugu caccacgaaa gccaagcagu ugaaagacag uguuacuugu     1140

agcccaggca uggugcgccu gucugaacuc aaguccacag uacagaacuc aagaccuauc     1200

aagaccgcga cuacacugcc cgaugacaug auaacccaaa gggaggaugc cgagggggug     1260

gcagcugaag aggaacagga gggagacagc ggcgagcagg aaacgggugc caccgaugcu     1320

cggccacgca gaaggaaacc cgcccgucuu cuggaggcaa cagccaagcc ugaaccagag     1380

gagaaaaguc gggcuaagcg acagaaagac uuugacauug cggaacaaaa ugagucuucc     1440

gaugaagaga gcuugagaaa ggaaagggca cgcucggccg aggaaccgug gacucagaac     1500

cagcagaagc uccuggaguu agcucugcaa caguaccccc gggggucuuc cgacagaugg     1560

gauaaaaucg ccaggugcgu cccuucaaag aguaaagagg acuguauugc acgcuauaag     1620

cuacucgugg aacugguuca gaaaaagaaa caagccaaga gcuga                     1665


<210>  8414
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC1__Homo_sapiens__AAI10895

<400>  8414
augaccgccc ccugcagcca gcccgcccag cugcccggca gaagacagcu gggccuggug       60

cccuuccccc cccccccccc cagaaccccc cugcuguggc ugcugcugcu gcugcuggcc      120

gccguggccc ccgccagagg cugggagagc ggcgaccugg agcuguucga ccugguggag      180

gaggugcagc ugaacuucua ccaguuccug ggcgugcagc aggacgccag cagcgccgac      240

aucagaaagg ccuacagaaa gcugagccug acccugcacc ccgacaagaa caaggacgag      300

aacgccgaga cccaguucag acagcuggug gccaucuacg aggugcugaa ggacgacgag      360

agaagacaga gauacgacga cauccugauc aacggccugc ccgacuggag acagcccgug      420

uucuacuaca gaagagugag aaagaugagc aacgccgagc uggcccugcu gcuguucauc      480

auccugaccg ugggccacua cgccguggug uggagcaucu accuggagaa gcagcuggac      540

gagcugcuga gcagaaagaa gagagagaag aagaagaaga ccggcagcaa gagcguggac      600

gugagcaagc ugggcgccag cgagaagaac gagagacugc ugaugaagcc ccaguggcac      660

gaccugcugc ccugcaagcu gggcaucugg uucugccuga cccugaaggc ccugccccac      720

cugauccagg acgccggcca guucuacgcc aaguacaagg agaccagacu gaaggagaag      780

gaggacgccc ugaccagaac cgagcuggag acccugcaga agcagaagaa ggugaagaag      840

cccaagcccg aguuccccgu guacaccccc cuggagacca ccuacaucca gagcuacgac      900

cacggcacca gcaucgagga gaucgaggag cagauggacg acuggcugga gaacagaaac      960

agaacccaga agaagcaggc ccccgagugg accgaggagg accugagcca gcugaccaga     1020

agcaugguga aguuccccgg cggcaccccc ggcagauggg agaagaucgc ccacgagcug     1080

ggcagaagcg ugaccgacgu gaccaccaag gccaagcagc ugaaggacag cgugaccugc     1140

agccccggca uggugagacu gagcgagcug aagagcaccg ugcagaacag cagacccauc     1200

aagaccgcca ccacccugcc cgacgacaug aucacccaga gagaggacgc cgagggcgug     1260

gccgccgagg aggagcagga gggcgacagc ggcgagcagg agaccggcgc caccgacgcc     1320

agacccagaa gaagaaagcc cgccagacug cuggaggcca ccgccaagcc cgagcccgag     1380

gagaagagca gagccaagag acagaaggac uucgacaucg ccgagcagaa cgagagcagc     1440

gacgaggaga gccugagaaa ggagagagcc agaagcgccg aggagcccug gacccagaac     1500

cagcagaagc ugcuggagcu ggcccugcag caguacccca gaggcagcag cgacagaugg     1560

gacaagaucg ccagaugcgu gcccagcaag agcaaggagg acugcaucgc cagauacaag     1620

cugcuggugg agcuggugca gaagaagaag caggccaaga gcuga                     1665


<210>  8415
<211>  1665
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC1__Homo_sapiens__AAI10895

<400>  8415
augaccgccc ccugcagcca gccugcucaa cugccgggca gacggcagcu cgggcuggug       60

cccuucccuc ccccuccccc ucgcacaccg cuucuguggc uccugcuucu gcuccuggcc      120

gcggucgcuc ccgccagagg augggagucc ggcgaccugg aacucuuuga ucugguugag      180

gaagugcagc uuaacuucua ccaguuucug ggggugcaac aggacgccuc uagcgcugau      240

auccggaagg ccuaucgcaa acucucccug acgcuucacc cugacaagaa uaaagaugag      300

aacgcugaaa cccaguucag acagcugguc gccauuuacg aggugcucaa ggacgaugag      360

cggcgccaaa gauaugacga uauccugauu aauggacugc ccgacuggcg gcagccugug      420

uuuuacuauc gcagaguucg gaaaaugucu aacgcggaac ucgcccugcu ucuguucauc      480

auucucacag ucggccauua cgcugugguu uggagcaucu aucuggagaa gcagcuugau      540

gaacugcucu cccgcaagaa aagagagaag aaaaagaaaa ccgggucuaa gagcguggac      600

gucuccaagc ugggagccag cgagaaaaau gaacggcugc ucaugaagcc ccaguggcac      660

gaucugcuuc cguguaaacu gggcaucugg uuuugccuca cacugaaggc ccuuccucau      720

cugauucaag acgcuggcca guucuacgcg aaauacaagg agacccgccu caaagaaaag      780

gaggacgccc ugacaagaac cgaacuggag acgcuccaga agcaaaagaa ggugaaaaag      840

cccaaaccug aguuucccgu guauacaccc cuggaaacca ccuacaucca gucuuaugau      900

cacgggacau ccauugagga aaucgaggaa cagauggacg auuggcuuga gaaccggaau      960

agaacccaga agaagcaagc uccugagugg acggaagagg accugagcca gcucacacgc     1020

ucuaugguca aauucccggg aggcaccccc gggcgguggg aaaagauugc ccaugagcug     1080

ggaagauccg uuacagaugu gaccaccaaa gcuaagcagc ugaaagacag cgugacaugu     1140

ucuccuggca ugguccgccu uuccgaacuc aagagcacgg ugcagaacuc ccggcccauc     1200

aagaccgcca caacccugcc ugaugacaug auuacacaaa gagaggaugc cgaggggguu     1260

gcugcggaag aggaacagga gggagacucu ggcgagcagg aaaccggcgc cacggaugcu     1320

cgcccccgga gacgcaaacc ggcccggcug cucgaggcca cagcuaagcc ugaacccgag     1380

gagaaaagca gagccaagcg ccagaaagac uuugacaucg cggaacaaaa ugaguccagc     1440

gaugaagagu cucugcggaa ggaaagagcu cgguccgccg aggaaccuug gacccagaac     1500

cagcagaaac uucuggagcu cgcccugcaa caguaccccc gcgggagcuc ugacagaugg     1560

gauaaaaucg cucggugcgu gccuagcaag uccaaagagg acuguauugc cagauauaag     1620

cugcuugucg aacucgugca gaaaaagaaa caagcuaagu cuuga                     1665


<210>  8416
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC2__Homo_sapiens__Q99543

<400>  8416

Met Leu Leu Leu Pro Ser Ala Ala Asp Gly Arg Gly Thr Ala Ile Thr 
1               5                   10                  15      


His Ala Leu Thr Ser Ala Ser Thr Leu Cys Gln Val Glu Pro Val Gly 
            20                  25                  30          


Arg Trp Phe Glu Ala Phe Val Lys Arg Arg Asn Arg Asn Ala Ser Ala 
        35                  40                  45              


Ser Phe Gln Glu Leu Glu Asp Lys Lys Glu Leu Ser Glu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Glu Leu Gln Leu Glu Glu Phe Pro Met Leu Lys Thr Leu Asp 
65                  70                  75                  80  


Pro Lys Asp Trp Lys Asn Gln Asp His Tyr Ala Val Leu Gly Leu Gly 
                85                  90                  95      


His Val Arg Tyr Lys Ala Thr Gln Arg Gln Ile Lys Ala Ala His Lys 
            100                 105                 110         


Ala Met Val Leu Lys His His Pro Asp Lys Arg Lys Ala Ala Gly Glu 
        115                 120                 125             


Pro Ile Lys Glu Gly Asp Asn Asp Tyr Phe Thr Cys Ile Thr Lys Ala 
    130                 135                 140                 


Tyr Glu Met Leu Ser Asp Pro Val Lys Arg Arg Ala Phe Asn Ser Val 
145                 150                 155                 160 


Asp Pro Thr Phe Asp Asn Ser Val Pro Ser Lys Ser Glu Ala Lys Asp 
                165                 170                 175     


Asn Phe Phe Glu Val Phe Thr Pro Val Phe Glu Arg Asn Ser Arg Trp 
            180                 185                 190         


Ser Asn Lys Lys Asn Val Pro Lys Leu Gly Asp Met Asn Ser Ser Phe 
        195                 200                 205             


Glu Asp Val Asp Ile Phe Tyr Ser Phe Trp Tyr Asn Phe Asp Ser Trp 
    210                 215                 220                 


Arg Glu Phe Ser Tyr Leu Asp Glu Glu Glu Lys Glu Lys Ala Glu Cys 
225                 230                 235                 240 


Arg Asp Glu Arg Arg Trp Ile Glu Lys Gln Asn Arg Ala Thr Arg Ala 
                245                 250                 255     


Gln Arg Lys Lys Glu Glu Met Asn Arg Ile Arg Thr Leu Val Asp Asn 
            260                 265                 270         


Ala Tyr Ser Cys Asp Pro Arg Ile Lys Lys Phe Lys Glu Glu Glu Lys 
        275                 280                 285             


Ala Lys Lys Glu Ala Glu Lys Lys Ala Lys Ala Glu Ala Lys Arg Lys 
    290                 295                 300                 


Glu Gln Glu Ala Lys Glu Lys Gln Arg Gln Ala Glu Leu Glu Ala Ala 
305                 310                 315                 320 


Arg Leu Ala Lys Glu Lys Glu Glu Glu Glu Val Arg Gln Gln Ala Leu 
                325                 330                 335     


Leu Ala Lys Lys Glu Lys Asp Ile Gln Lys Lys Ala Ile Lys Lys Glu 
            340                 345                 350         


Arg Gln Lys Leu Arg Asn Ser Cys Lys Thr Trp Asn His Phe Ser Asp 
        355                 360                 365             


Asn Glu Ala Glu Arg Val Lys Met Met Glu Glu Val Glu Lys Leu Cys 
    370                 375                 380                 


Asp Arg Leu Glu Leu Ala Ser Leu Gln Cys Leu Asn Glu Thr Leu Thr 
385                 390                 395                 400 


Ser Cys Thr Lys Glu Val Gly Lys Ala Ala Leu Glu Lys Gln Ile Glu 
                405                 410                 415     


Glu Ile Asn Glu Gln Ile Arg Lys Glu Lys Glu Glu Ala Glu Ala Arg 
            420                 425                 430         


Met Arg Gln Ala Ser Lys Asn Thr Glu Lys Ser Thr Gly Gly Gly Gly 
        435                 440                 445             


Asn Gly Ser Lys Asn Trp Ser Glu Asp Asp Leu Gln Leu Leu Ile Lys 
    450                 455                 460                 


Ala Val Asn Leu Phe Pro Ala Gly Thr Asn Ser Arg Trp Glu Val Ile 
465                 470                 475                 480 


Ala Asn Tyr Met Asn Ile His Ser Ser Ser Gly Val Lys Arg Thr Ala 
                485                 490                 495     


Lys Asp Val Ile Gly Lys Ala Lys Ser Leu Gln Lys Leu Asp Pro His 
            500                 505                 510         


Gln Lys Asp Asp Ile Asn Lys Lys Ala Phe Asp Lys Phe Lys Lys Glu 
        515                 520                 525             


His Gly Val Val Pro Gln Ala Asp Asn Ala Thr Pro Ser Glu Arg Phe 
    530                 535                 540                 


Glu Gly Pro Tyr Thr Asp Phe Thr Pro Trp Thr Thr Glu Glu Gln Lys 
545                 550                 555                 560 


Leu Leu Glu Gln Ala Leu Lys Thr Tyr Pro Val Asn Thr Pro Glu Arg 
                565                 570                 575     


Trp Glu Lys Ile Ala Glu Ala Val Pro Gly Arg Thr Lys Lys Asp Cys 
            580                 585                 590         


Met Lys Arg Tyr Lys Glu Leu Val Glu Met Val Lys Ala Lys Lys Ala 
        595                 600                 605             


Ala Gln Glu Gln Val Leu Asn Ala Ser Arg Ala Lys Lys 
    610                 615                 620     


<210>  8417
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC2__Homo_sapiens__CCDS43628.1

<400>  8417
augcugcuuc ugccaagcgc cgcggacggc cggggcaccg ccaucaccca cgcucugacc       60

ucugccucua cacucuguca aguugaaccu gugggaagau gguuugaagc uuuuguuaag      120

aggagaaaca gaaaugcuuc ugccucuuuu caggaacugg aggauaagaa agaguuaucc      180

gaggaaucag aagaugaaga auugcaguug gaagaguuuc ccaugcugaa aacacuugau      240

cccaaagacu ggaagaacca agaucauuau gcaguucuug gacuuggcca ugugagauac      300

aaggcuacac agagacagau caaagcagcu cauaaagcaa ugguuuuaaa acaucaccca      360

gacaaacgga aagcagcugg ugaaccaaua aaagaaggag auaaugacua cuucacuugc      420

auaacuaaag cuuaugaaau guuaucugau ccagugaaaa gacgagcauu uaacagugua      480

gauccuacuu uugauaacuc aguuccuucu aaaagugaag caaaggauaa uuucuucgaa      540

guguuuaccc caguguuuga aaggaauucc agauggucaa auaaaaaaaa uguuccuaaa      600

cuuggugaua ugaauucauc auuugaagau guagauauau uuuauucuuu cugguauaau      660

uuugauucuu ggagagaauu uucuuauuua gaugaagaag aaaaagaaaa agcagaaugu      720

cgugaugaga ggagauggau ugaaaagcag aacagagcaa caagagcaca aagaaaaaaa      780

gaagaaauga acagaauaag aacauuaguu gacaaugcau acagcuguga uccaaggaua      840

aaaaaguuca aggaagaaga aaaagccaag aaagaagcag aaaagaaagc aaaagcagaa      900

gcuaaacgga aggagcaaga agcuaaagaa aaacaaagac aagcugaauu agaagcugcu      960

cgguuagcua aggagaaaga agaggaggaa gucagacagc aagcauugcu ggcaaagaag     1020

gaaaaagaua uccagaaaaa agccauuaag aaggaaaggc aaaaacuucg aaacucaugc     1080

aagaccugga aucauuuuuc ugauaaugag gcagagcggg uuaaaaugau ggaagaagug     1140

gaaaaacuuu gugaucggcu ugaacuggca agcuuacagu gcuugaauga aacacucaca     1200

ucaugcacaa aagaaguagg aaaggcugcu uuggaaaaac agauagaaga aauaaaugag     1260

caaaucagaa aagagaaaga ggaagcugag gcucguaugc gacaagcauc uaagaacaca     1320

gagaaaucaa cugguggagg uggaaaugga aguaaaaauu ggucagaaga ugaucuacaa     1380

uuacuaauua aagcugugaa ucuguucccu gcuggaacaa auucaagaug ggaaguuauu     1440

gcuaauuaca ugaacauaca uucuuccucu ggagucaaaa gaacugccaa agauguuauu     1500

ggcaaagcaa agagucucca aaaacuugac ccucaucaaa aagaugacau aaauaaaaag     1560

gcauuugaua aguucaaaaa agaacaugga gugguaccuc aagcagacaa cgcaacgccu     1620

ucagaacgau uugaaggucc auauacagac uucaccccuu ggacaacaga agaacagaag     1680

cuuuuggaac aagcuuugaa aacauaccca guaaauacac cugaaagaug ggaaaaaaua     1740

gcagaagcgg ugccuggcag gacaaagaag gacugcauga aacgauacaa ggaacuuguc     1800

gagaugguaa aagcaaagaa agcugcucaa gaacaagugc ugaaugcaag uagagccaag     1860

aaauga                                                                1866


<210>  8418
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC2__Homo_sapiens__CCDS43628.1

<400>  8418
augcugcucc ugcccagcgc cgccgacggc cgcgggaccg cgaucaccca cgcccugacg       60

uccgccagca cccucugcca gguggagccg gugggccggu gguucgaggc cuucgugaag      120

cgccggaacc gcaacgccuc cgcgagcuuc caggagcugg aggacaagaa ggagcugucc      180

gaggagagcg aggacgagga gcuccagcug gaggaguucc ccaugcugaa gacccucgac      240

cccaaggacu ggaagaacca ggaccacuac gccgugcugg ggcugggcca cguccgguac      300

aaggccaccc agcgccagau caaggccgcg cacaaggcca uggugcucaa gcaccacccc      360

gacaagcgga aggccgccgg ggagccgauc aaggagggcg acaacgacua cuucacgugc      420

aucaccaagg ccuacgagau gcuguccgac cccgugaagc gccgggcguu caacagcguc      480

gaccccaccu ucgacaacuc cgugcccagc aaguccgagg ccaaggacaa cuucuucgag      540

guguucaccc cggucuucga gcgcaacagc cgguggucca acaagaagaa cgugcccaag      600

cugggcgaca ugaacagcuc cuucgaggac guggacaucu ucuacagcuu cugguacaac      660

uucgacuccu ggcgcgaguu cagcuaccuc gacgaggagg agaaggagaa ggccgagugc      720

cgggacgagc gccgguggau cgagaagcag aaccgcgcca cgcgggccca gcgcaagaag      780

gaggagauga accggauccg cacccugguc gacaacgcgu acuccugcga cccccggauc      840

aagaaguuca aggaggagga gaaggccaag aaggaggccg agaagaaggc caaggccgag      900

gcgaagcgca aggagcagga ggccaaggag aagcagcgcc aggccgagcu ggaggccgcc      960

cggcucgcga aggagaagga ggaggaggag gugcgccagc aggcccugcu ggccaagaag     1020

gagaaggaca uccagaagaa ggccaucaag aaggagcggc agaagcuccg caacagcugc     1080

aagaccugga accacuucag cgacaacgag gcggagcggg ugaagaugau ggaggagguc     1140

gagaagcugu gcgaccgccu ggagcucgcc ucccugcagu gccugaacga gacccucacg     1200

agcugcacca aggagguggg gaaggccgcc cuggagaagc agaucgagga gaucaacgag     1260

cagauccgga aggagaagga ggaggccgag gcgcgcaugc ggcaggccuc caagaacacc     1320

gagaagucca ccggcggggg cgggaacggc agcaagaacu ggagcgagga cgaccugcag     1380

cuccugauca aggccgugaa ccuguucccc gccggcacga acucccgcug ggaggucauc     1440

gccaacuaca ugaacaucca cagcuccagc ggggugaagc ggaccgcgaa ggacgugauc     1500

ggcaaggcca agucccucca gaagcuggac ccgcaccaga aggacgacau caacaagaag     1560

gccuucgaca aguucaagaa ggagcacggg gucgugcccc aggccgacaa cgccaccccc     1620

agcgagcgcu ucgagggccc cuacaccgac uucacgccgu ggaccaccga ggagcagaag     1680

cugcucgagc aggcgcugaa gaccuacccc gugaacacgc ccgagcggug ggagaagauc     1740

gccgaggccg uccccggccg caccaagaag gacugcauga agcgguacaa ggagcuggug     1800

gagaugguca aggccaagaa ggcggcccag gagcaggucc ucaacgccuc ccgcgccaag     1860

aaguga                                                                1866


<210>  8419
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC2__Homo_sapiens__CCDS43628.1

<400>  8419
augcuccucc uccccuccgc cgccgacggc cgcggcaccg ccaucaccca cgcccucacc       60

uccgccucca cccucugcca ggucgagccc gucggccgcu gguucgaggc cuucgucaag      120

cgccgcaacc gcaacgccuc cgccuccuuc caggagcucg aggacaagaa ggagcucucc      180

gaggaguccg aggacgagga gcuccagcuc gaggaguucc ccaugcucaa gacccucgac      240

cccaaggacu ggaagaacca ggaccacuac gccguccucg gccucggcca cguccgcuac      300

aaggccaccc agcgccagau caaggccgcc cacaaggcca ugguccucaa gcaccacccc      360

gacaagcgca aggccgccgg cgagcccauc aaggagggcg acaacgacua cuucaccugc      420

aucaccaagg ccuacgagau gcucuccgac cccgucaagc gccgcgccuu caacuccguc      480

gaccccaccu ucgacaacuc cguccccucc aaguccgagg ccaaggacaa cuucuucgag      540

gucuucaccc ccgucuucga gcgcaacucc cgcuggucca acaagaagaa cguccccaag      600

cucggcgaca ugaacuccuc cuucgaggac gucgacaucu ucuacuccuu cugguacaac      660

uucgacuccu ggcgcgaguu cuccuaccuc gacgaggagg agaaggagaa ggccgagugc      720

cgcgacgagc gccgcuggau cgagaagcag aaccgcgcca cccgcgccca gcgcaagaag      780

gaggagauga accgcauccg cacccucguc gacaacgccu acuccugcga cccccgcauc      840

aagaaguuca aggaggagga gaaggccaag aaggaggccg agaagaaggc caaggccgag      900

gccaagcgca aggagcagga ggccaaggag aagcagcgcc aggccgagcu cgaggccgcc      960

cgccucgcca aggagaagga ggaggaggag guccgccagc aggcccuccu cgccaagaag     1020

gagaaggaca uccagaagaa ggccaucaag aaggagcgcc agaagcuccg caacuccugc     1080

aagaccugga accacuucuc cgacaacgag gccgagcgcg ucaagaugau ggaggagguc     1140

gagaagcucu gcgaccgccu cgagcucgcc ucccuccagu gccucaacga gacccucacc     1200

uccugcacca aggaggucgg caaggccgcc cucgagaagc agaucgagga gaucaacgag     1260

cagauccgca aggagaagga ggaggccgag gcccgcaugc gccaggccuc caagaacacc     1320

gagaagucca ccggcggcgg cggcaacggc uccaagaacu gguccgagga cgaccuccag     1380

cuccucauca aggccgucaa ccucuucccc gccggcacca acucccgcug ggaggucauc     1440

gccaacuaca ugaacaucca cuccuccucc ggcgucaagc gcaccgccaa ggacgucauc     1500

ggcaaggcca agucccucca gaagcucgac ccccaccaga aggacgacau caacaagaag     1560

gccuucgaca aguucaagaa ggagcacggc gucguccccc aggccgacaa cgccaccccc     1620

uccgagcgcu ucgagggccc cuacaccgac uucacccccu ggaccaccga ggagcagaag     1680

cuccucgagc aggcccucaa gaccuacccc gucaacaccc ccgagcgcug ggagaagauc     1740

gccgaggccg uccccggccg caccaagaag gacugcauga agcgcuacaa ggagcucguc     1800

gagaugguca aggccaagaa ggccgcccag gagcaggucc ucaacgccuc ccgcgccaag     1860

aaguga                                                                1866


<210>  8420
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC2__Homo_sapiens__CCDS43628.1

<400>  8420
augcugcucc uucccagcgc cgcugacggc agagggaccg caaucacaca cgcccugacu       60

uccgcgucua cguugugcca gguggagccu gucggaaggu gguucgaagc auuuguuaag      120

cggcgcaacc gaaaugccuc agcaaguuuc caagaguuag aagauaaaaa ggagcugagc      180

gaagaguccg aggacgagga gcuacagcuc gaagaguuuc caaugcugaa aacccuugau      240

ccgaaggacu ggaaaaacca ggaucauuac gccgugcugg guuugggcca cguacguuau      300

aaggcuacac agagacaaau uaaggcagcc cauaaagcua uggugcucaa gcaccauccc      360

gacaaaagga aggccgcggg ggagccuaua aaagaaggag auaaugacua cuucacuugu      420

aucaccaagg cauaugagau gcugucugau ccagucaagc ggcgcgccuu uaacucggug      480

gaccccacau ucgauaauuc aguuccuagc aaaagugaag cuaaggacaa cuuuuucgag      540

guguuuaccc cagucuucga aagaaauucc agguggucua acaaaaagaa ugugcccaaa      600

cugggcgaua ugaacagcuc cuuugaggac guagacauuu ucuacucauu uugguauaau      660

uucgauaguu ggcgggaguu cagcuaccuc gacgaagagg aaaaggagaa agccgaaugc      720

cgcgaugagc gaagauggau cgagaagcag aacagggcaa cucgggcuca gcguaagaaa      780

gaagagauga aucgcauuag aacauuaguu gacaacgccu auucuuguga uccuaggauc      840

aagaaauuua aggaagagga aaaagcgaag aaggaggccg agaaaaaggc aaaagcugaa      900

gccaagcgga aagagcagga agcuaaggag aagcaacgac aggccgagcu ggaagcagcc      960

cgccuugcua aagagaagga agaggaagag gugagacagc aggcguugcu ggcuaaaaag     1020

gagaaagaca uacaaaagaa ggccaucaaa aaggaaaggc agaaacuacg gaauaguugc     1080

aagaccugga accacuucuc agauaacgag gcugaacgcg ucaaaaugau ggaggaagug     1140

gagaagcucu gugacagacu ggagcuugcc agccugcagu gcuugaauga aacgcucacu     1200

uccuguacca aagagguggg uaaggcagcc cuggaaaagc aaauugagga aaucaacgag     1260

cagauuagga aagagaagga agaggcugaa gcccguaugc ggcaggcauc uaaaaauaca     1320

gagaagucca cugggggagg cggcaacggg agcaaaaauu ggucggagga ugacuuacag     1380

cugcucauca aggcggucaa ccuuuuucca gcuggaacca auucucgaug ggaaguuaua     1440

gccaacuaca ugaauauuca cuccucaagu ggugugaaga gaacagcaaa agauguaauc     1500

ggcaaggcca aaagccugca aaaguuggac ccgcaucaga aagacgauau uaacaagaag     1560

gcuuucgaca aauuuaagaa agagcacggg gugguccccc aggccgauaa ugcaaccccu     1620

uccgaaaggu ucgagggacc auacacggac uuuacucccu ggacaaccga ggaacagaag     1680

cuacuggagc aagcucucaa aacuuauccu gugaacacac cagaacgcug ggagaagauc     1740

gccgaagcgg uucccggccg gaccaagaaa gauugcauga agagauacaa agagcuggug     1800

gaaaugguca aggccaaaaa ggcugcacag gaacaggugc uuaaugccuc uagggcuaaa     1860

aaguga                                                                1866


<210>  8421
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC2__Homo_sapiens__CCDS43628.1

<400>  8421
augcugcugc ugcccagcgc cgccgacggc agaggcaccg ccaucaccca cgcccugacc       60

agcgccagca cccugugcca gguggagccc gugggcagau gguucgaggc cuucgugaag      120

agaagaaaca gaaacgccag cgccagcuuc caggagcugg aggacaagaa ggagcugagc      180

gaggagagcg aggacgagga gcugcagcug gaggaguucc ccaugcugaa gacccuggac      240

cccaaggacu ggaagaacca ggaccacuac gccgugcugg gccugggcca cgugagauac      300

aaggccaccc agagacagau caaggccgcc cacaaggcca uggugcugaa gcaccacccc      360

gacaagagaa aggccgccgg cgagcccauc aaggagggcg acaacgacua cuucaccugc      420

aucaccaagg ccuacgagau gcugagcgac cccgugaaga gaagagccuu caacagcgug      480

gaccccaccu ucgacaacag cgugcccagc aagagcgagg ccaaggacaa cuucuucgag      540

guguucaccc ccguguucga gagaaacagc agauggagca acaagaagaa cgugcccaag      600

cugggcgaca ugaacagcag cuucgaggac guggacaucu ucuacagcuu cugguacaac      660

uucgacagcu ggagagaguu cagcuaccug gacgaggagg agaaggagaa ggccgagugc      720

agagacgaga gaagauggau cgagaagcag aacagagcca ccagagccca gagaaagaag      780

gaggagauga acagaaucag aacccuggug gacaacgccu acagcugcga ccccagaauc      840

aagaaguuca aggaggagga gaaggccaag aaggaggccg agaagaaggc caaggccgag      900

gccaagagaa aggagcagga ggccaaggag aagcagagac aggccgagcu ggaggccgcc      960

agacuggcca aggagaagga ggaggaggag gugagacagc aggcccugcu ggccaagaag     1020

gagaaggaca uccagaagaa ggccaucaag aaggagagac agaagcugag aaacagcugc     1080

aagaccugga accacuucag cgacaacgag gccgagagag ugaagaugau ggaggaggug     1140

gagaagcugu gcgacagacu ggagcuggcc agccugcagu gccugaacga gacccugacc     1200

agcugcacca aggagguggg caaggccgcc cuggagaagc agaucgagga gaucaacgag     1260

cagaucagaa aggagaagga ggaggccgag gccagaauga gacaggccag caagaacacc     1320

gagaagagca ccggcggcgg cggcaacggc agcaagaacu ggagcgagga cgaccugcag     1380

cugcugauca aggccgugaa ccuguucccc gccggcacca acagcagaug ggaggugauc     1440

gccaacuaca ugaacaucca cagcagcagc ggcgugaaga gaaccgccaa ggacgugauc     1500

ggcaaggcca agagccugca gaagcuggac ccccaccaga aggacgacau caacaagaag     1560

gccuucgaca aguucaagaa ggagcacggc guggugcccc aggccgacaa cgccaccccc     1620

agcgagagau ucgagggccc cuacaccgac uucacccccu ggaccaccga ggagcagaag     1680

cugcuggagc aggcccugaa gaccuacccc gugaacaccc ccgagagaug ggagaagauc     1740

gccgaggccg ugcccggcag aaccaagaag gacugcauga agagauacaa ggagcuggug     1800

gagaugguga aggccaagaa ggccgcccag gagcaggugc ugaacgccag cagagccaag     1860

aaguga                                                                1866


<210>  8422
<211>  1866
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC2__Homo_sapiens__CCDS43628.1

<400>  8422
augcugcucc ugcccagcgc cgcugacggc agagggaccg ccaucacaca cgcgcuuacg       60

uccgcuucua cccugugcca gguggagccu gucggacggu gguucgaagc cuuuguuaag      120

cgcagaaacc ggaaugccag cgcuuccuuc caagagcucg aagauaaaaa ggagcugucu      180

gaagagagcg aggacgaaga acuucagcug gaagaguuuc cgaugcucaa aacacuggau      240

cccaaggacu ggaaaaacca ggaucauuac gccgugcugg gccucgggca cgugcgcuau      300

aaggcuaccc agagacaaau uaaggccgcg cauaaagcca ugguccugaa gcaccauccu      360

gacaaacgga aggcugccgg agagcccauc aaagaaggcg auaaugacua cuucacaugu      420

auuaccaagg cuuaugagau gcuuuccgau ccugugaagc gcagagccuu uaacucuguu      480

gaccccacau ucgauaauag cgugccuucc aaaagcgaag cgaaggacaa cuuuuucgag      540

gucuuuaccc cgguguucga acggaauagc cgcuggucca acaaaaagaa uguucccaaa      600

cugggggaua ugaacagcuc uuuugaggac guggacaucu ucuacuccuu uugguauaau      660

uucgauagcu ggagagaguu cucuuaccuc gacgaagagg aaaaggagaa agccgaaugc      720

cgggaugagc gcagauggau ugagaagcag aaccgggcua cgcgcgccca gagaaagaaa      780

gaagagauga aucggaucag aacccugguc gacaacgcuu auuccuguga uccucgcauc      840

aagaaauuua aggaagagga aaaagccaag aaggaggccg agaaaaaggc uaaagcggaa      900

gccaagcgga aagagcagga agcuaaggag aagcaaagac aggccgagcu ugaagccgcu      960

cgccuggcca aagagaagga agaggaagag gugcggcagc aggcgcuccu ggcuaaaaag     1020

gagaaagaca uucaaaagaa ggccaucaaa aaggaaagac agaaacugcg caauagcugc     1080

aagacaugga accacuucuc cgauaacgag gccgaacggg ugaaaaugau ggaggaaguc     1140

gagaagcucu gugacagacu ggagcuugcu ucucugcagu gccucaauga aacccugaca     1200

agcuguacca aagagguugg aaaggccgcu cuugaaaagc aaauugagga aaucaacgag     1260

cagauucgca aagagaagga agaggccgaa gcgcggauga gacaggccuc caaaaauacg     1320

gagaagucua caggcggcgg gggaaacggc ucuaaaaauu gguccgagga ugaccugcag     1380

cuccugauca aggcugugaa ccuguuuccc gccgggacca auagccgcug ggaagugauu     1440

gcuaacuaca ugaauaucca cucuagcucc ggagucaagc ggacagccaa agaugugauc     1500

ggcaaggcga aaucucucca aaagcuggac ccucaucaga aagacgauau uaacaagaag     1560

gccuucgaca aauuuaagaa agagcacggg guugugcccc aggcugauaa ugccaccccg     1620

agcgaaagau ucgagggacc uuacaccgac uuuacacccu ggacgaccga ggagcagaaa     1680

cuucuggagc aagcucucaa gacauauccu gucaacaccc ccgaacggug ggagaagauc     1740

gccgaagccg ugcccggccg cacaaagaaa gauugcauga agagauacaa agagcugguu     1800

gaaaugguga aggcuaaaaa ggcggcccag gagcaggucc uuaaugcuuc ccgggccaaa     1860

aaguga                                                                1866


<210>  8423
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC3__Homo_sapiens__Q13217

<400>  8423

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala 
    130                 135                 140                 


Gln Ser Gln Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln 
145                 150                 155                 160 


Ala Leu Asn Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe 
                165                 170                 175     


Leu Asp Lys Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu 
            180                 185                 190         


Leu Arg Ala Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile 
        195                 200                 205             


Ser Asp Leu Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala 
    210                 215                 220                 


Phe Tyr Lys Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu 
225                 230                 235                 240 


Ser Leu Ser Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys 
                245                 250                 255     


Arg Cys Phe Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile 
            260                 265                 270         


Glu Ser Ala Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr 
        275                 280                 285             


Ser Lys Tyr Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr 
    290                 295                 300                 


Thr Val Arg Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu 
305                 310                 315                 320 


Lys Pro Val Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu 
                325                 330                 335     


Pro Asp Asn Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile 
            340                 345                 350         


Glu Glu Met Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu 
        355                 360                 365             


His Asn Glu Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln 
    370                 375                 380                 


Arg Leu Leu Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly 
385                 390                 395                 400 


Val Lys Arg Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys 
                405                 410                 415     


Leu Ala Leu Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys 
            420                 425                 430         


Lys Lys Ala Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val 
        435                 440                 445             


Leu Ser Asp Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro 
    450                 455                 460                 


Leu Asp Ala Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg 
465                 470                 475                 480 


Ser Trp Asn Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro 
                485                 490                 495     


Phe Arg Phe Lys Phe His Phe Asn 
            500                 


<210>  8424
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC3__Homo_sapiens__AAC50502

<400>  8424
augguggccc ccggcuccgu gaccagccgg cugggcucgg uauuccccuu ccugcuaguc       60

cugguggauc ugcaguacga aggugcugaa uguggaguaa augcagaugu ugagaaacau      120

cuugaauugg gcaagaaauu acuugcagcu ggacagcuag cugaugcuuu aucucaguuu      180

caugcugccg uagaugguga cccugauaac uauauugcuu auuaucggag ggcuacuguc      240

uuuuuagcua ugggcaaauc aaaagcugca cuuccugauu uaacuaaagu gauucaauug      300

aagauggacu ucacugcagc aagauuacag agaggucacu uauuacucaa acaaggaaaa      360

cuugaugaag cagaagauga uuuuaaaaaa gugcucaaau cuaauccaag ugaaaaugaa      420

gaaaaggaag cacagucuca acuuauaaaa ucugaugaaa ugcagcguuu gcguucacaa      480

gcacuuaacg cuuuuggaag uggagauuau acugcugcua uagccuuccu ugauaagauu      540

uuagagguuu guguuuggga ugcagaacua cgggaacuuc gagcugaaug uuuuauaaaa      600

gaaggagaac cuaggaaagc uauaagugac uuaaaagcug cgucaaaguu gaagaaugau      660

aauacugaag cguuuuauaa aauaagcaca cuguacuacc aacuaggaga ccacgaacug      720

ucccucagug aaguucggga augucuuaaa cuugaccagg aucauaaaag guguuuugca      780

cacuauaaac aaguaaagaa acuuaauaag cugauugagu cagcugaaga gcucaucaga      840

gauggcagau acacagaugc uaccagcaaa uaugaaucug ucaugaaaac agagccaagc      900

auugcugaau auacaguucg uucaaaggag aggauuugcc acugcuuuuc uaaggacgag      960

aagccuguug aagcuauuag gguuuguucu gaaguuuuac agauggaacc ugacaaugug     1020

aaugcccuga aagaucgagc ugaggccuau uugauagagg aaauguauga ugaagcuauu     1080

caggauuaug aaacugcuca ggaacacaau gaaaaugauc agcagauucg agaaggucua     1140

gagaaagcac aaagauuauu gaaacagucg cagaaacgag auuauuauaa aaucuuggga     1200

guaaaaagaa augccaaaaa gcaagaaauu auuaaagcau accgaaaauu agcacugcag     1260

uggcacccag auaacuucca gaaugaagaa gaaaagaaaa aagcugagaa aaaguucauu     1320

gauauagcag cugcuaaaga aguccucucu gauccagaaa ugagaaagaa guuugacgac     1380

ggagaagauc cuuuggaugc agagagccag caaggaggcg gcggcaaccc uuuccacaga     1440

agcuggaacu cauggcaagg guucaauccc uucagcucag gcggaccauu uagauuuaaa     1500

uuccacuuca auuaa                                                      1515


<210>  8425
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC3__Homo_sapiens__AAC50502

<400>  8425
augguggccc ccggcagcgu caccucccgc cuggggagcg uguucccguu ccuccuggug       60

cuggucgacc uccaguacga gggcgccgag ugcgggguga acgcggacgu ggagaagcac      120

cuggagcugg gcaagaagcu ccuggccgcc gggcagcugg ccgacgcccu cucccaguuc      180

cacgcggccg ucgacggcga ccccgacaac uacaucgccu acuaccggcg cgccaccgug      240

uuccuggcga ugggcaagag caaggccgcc cugcccgacc ucacgaaggu gauccagcug      300

aagauggacu ucaccgccgc ccggcugcag cgcgggcacc uccugcugaa gcagggcaag      360

cucgacgagg cggaggacga cuucaagaag guccugaagu ccaaccccag cgagaacgag      420

gagaaggagg cccaguccca gcugaucaag agcgacgaga ugcagcggcu ccgcucccag      480

gcccugaacg ccuucgggag cggcgacuac accgccgcga ucgccuuccu ggacaagauc      540

cucgaggugu gcguguggga cgccgagcug cgggagcugc gcgccgagug cuucaucaag      600

gagggggagc cgcggaaggc caucuccgac cucaaggcgg ccagcaagcu gaagaacgac      660

aacaccgagg ccuucuacaa gaucuccacg cuguacuacc agcucggcga ccacgagcug      720

agccuguccg agguccgcga gugccucaag cuggaccagg accacaagcg gugcuucgcc      780

cacuacaagc aggucaagaa gcugaacaag cucaucgaga gcgccgagga gcugauccgc      840

gacggccggu acaccgacgc gaccuccaag uacgagagcg ugaugaagac cgagcccucc      900

aucgccgagu acacggugcg cagcaaggag cggaucugcc acugcuucag caaggacgag      960

aagcccgugg aggccauccg cgugugcucc gagguccugc agauggagcc cgacaacgug     1020

aacgcccuca aggaccgggc ggaggccuac cugaucgagg agauguacga cgaggccauc     1080

caggacuacg agaccgccca ggagcacaac gagaacgacc agcagauccg cgaggggcug     1140

gagaaggccc agcggcuccu gaagcagagc cagaagcgcg acuacuacaa gauccugggc     1200

gugaagcgga acgcgaagaa gcaggagauc aucaaggccu accgcaagcu cgcccugcag     1260

uggcacccgg acaacuucca gaacgaggag gagaagaaga aggccgagaa gaaguucauc     1320

gacaucgccg cggccaagga gguccugucc gaccccgaga ugcgcaagaa guucgacgac     1380

ggggaggacc cccucgacgc cgagagccag cagggcggcg ggggcaaccc cuuccaccgg     1440

uccuggaaca gcuggcaggg guucaacccg uucuccagcg gcgggcccuu ccgcuucaag     1500

uuccacuuca acuga                                                      1515


<210>  8426
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC3__Homo_sapiens__AAC50502

<400>  8426
auggucgccc ccggcuccgu caccucccgc cucggcuccg ucuuccccuu ccuccucguc       60

cucgucgacc uccaguacga gggcgccgag ugcggcguca acgccgacgu cgagaagcac      120

cucgagcucg gcaagaagcu ccucgccgcc ggccagcucg ccgacgcccu cucccaguuc      180

cacgccgccg ucgacggcga ccccgacaac uacaucgccu acuaccgccg cgccaccguc      240

uuccucgcca ugggcaaguc caaggccgcc cuccccgacc ucaccaaggu cauccagcuc      300

aagauggacu ucaccgccgc ccgccuccag cgcggccacc uccuccucaa gcagggcaag      360

cucgacgagg ccgaggacga cuucaagaag guccucaagu ccaaccccuc cgagaacgag      420

gagaaggagg cccaguccca gcucaucaag uccgacgaga ugcagcgccu ccgcucccag      480

gcccucaacg ccuucggcuc cggcgacuac accgccgcca ucgccuuccu cgacaagauc      540

cucgaggucu gcgucuggga cgccgagcuc cgcgagcucc gcgccgagug cuucaucaag      600

gagggcgagc cccgcaaggc caucuccgac cucaaggccg ccuccaagcu caagaacgac      660

aacaccgagg ccuucuacaa gaucuccacc cucuacuacc agcucggcga ccacgagcuc      720

ucccucuccg agguccgcga gugccucaag cucgaccagg accacaagcg cugcuucgcc      780

cacuacaagc aggucaagaa gcucaacaag cucaucgagu ccgccgagga gcucauccgc      840

gacggccgcu acaccgacgc caccuccaag uacgaguccg ucaugaagac cgagcccucc      900

aucgccgagu acaccguccg cuccaaggag cgcaucugcc acugcuucuc caaggacgag      960

aagcccgucg aggccauccg cgucugcucc gagguccucc agauggagcc cgacaacguc     1020

aacgcccuca aggaccgcgc cgaggccuac cucaucgagg agauguacga cgaggccauc     1080

caggacuacg agaccgccca ggagcacaac gagaacgacc agcagauccg cgagggccuc     1140

gagaaggccc agcgccuccu caagcagucc cagaagcgcg acuacuacaa gauccucggc     1200

gucaagcgca acgccaagaa gcaggagauc aucaaggccu accgcaagcu cgcccuccag     1260

uggcaccccg acaacuucca gaacgaggag gagaagaaga aggccgagaa gaaguucauc     1320

gacaucgccg ccgccaagga gguccucucc gaccccgaga ugcgcaagaa guucgacgac     1380

ggcgaggacc cccucgacgc cgagucccag cagggcggcg gcggcaaccc cuuccaccgc     1440

uccuggaacu ccuggcaggg cuucaacccc uucuccuccg gcggccccuu ccgcuucaag     1500

uuccacuuca acuga                                                      1515


<210>  8427
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC3__Homo_sapiens__AAC50502

<400>  8427
augguggccc ccggcagcgu caccuccaga cuggggucug uuuucccuuu ucuccuugug       60

cugguagacu ugcaguacga gggagcugaa ugcgguguga acgcagaugu cgagaagcac      120

uuagaacugg gcaaaaagcu acucgccgcg gggcaacugg cugacgcccu uucacaguuc      180

caugcagccg uggauggaga cccagauaau uauaucgcuu acuauaggcg ggcaacaguu      240

uuucuggcca ugggcaaaag uaaggcugcc uugccggacc ucacuaaagu gauucagcug      300

aagauggauu ucacggcggc acgccugcag cgaggucacc ucuuacugaa gcaagggaaa      360

cuugacgagg ccgaagauga cuuuaagaaa guccucaaga gcaaccccuc cgagaaugag      420

gaaaaagagg cucagucuca gcugauaaag ucggaugaaa ugcagcgucu aagaucacaa      480

gcccucaacg cauucggaag cggcgacuac accgcugcca ucgcguuucu ggauaagauu      540

cuugaggugu guguauggga cgccgagcug agggaauugc gggcagagug cuucaucaaa      600

gaaggcgagc cucgcaaggc uauuagugac cucaaagccg cuuccaagcu gaaaaaugau      660

aacacagaag ccuuuuauaa gaucucuacu uuauacuauc agcuggggga ccaugagcuc      720

agccuuuccg agguuagaga augucugaaa uuggaucagg accacaagag gugcuucgca      780

cauuacaaac aggugaaaaa gcuaaauaaa cugauagagu cagccgaaga guugauccgg      840

gauggacgcu acaccgacgc uacaaguaag uaugaaagcg ucaugaaaac cgagccaucu      900

auugcggagu acacugugcg auccaaggaa agaaucuguc acugcuuuuc aaaggaugag      960

aaacccgugg aagcaauuag ggucuguagc gagguucugc aaauggaacc ugacaacgug     1020

aaugcccuua aggaucgggc ugaggccuau cugaucgagg aaauguacga cgaggcaaua     1080

caggauuaug aaacagccca ggagcacaac gagaaugacc aacagauucg ugaagguuug     1140

gagaaagcuc agcgccuccu gaagcagagu caaaagagag acuacuauaa gaucuuaggc     1200

guaaagagga acgccaaaaa gcaggaaauu aucaaagcau accggaagcu ggcgcuacag     1260

uggcauccag auaauuucca gaacgaggaa gagaaaaaga aggcugagaa aaaguuuauc     1320

gacauugccg cagccaaaga agugcucucu gaucccgaga ugcgaaagaa auucgacgau     1380

ggggaagacc cucuggaugc ugagucccaa cagggaggcg gugggaaucc auuccaccgc     1440

agcuggaacu cguggcaggg auuuaacccg uucucuuccg gcggccccuu uagauucaag     1500

uuucauuuca auuga                                                      1515


<210>  8428
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC3__Homo_sapiens__AAC50502

<400>  8428
augguggccc ccggcagcgu gaccagcaga cugggcagcg uguuccccuu ccugcuggug       60

cugguggacc ugcaguacga gggcgccgag ugcggcguga acgccgacgu ggagaagcac      120

cuggagcugg gcaagaagcu gcuggccgcc ggccagcugg ccgacgcccu gagccaguuc      180

cacgccgccg uggacggcga ccccgacaac uacaucgccu acuacagaag agccaccgug      240

uuccuggcca ugggcaagag caaggccgcc cugcccgacc ugaccaaggu gauccagcug      300

aagauggacu ucaccgccgc cagacugcag agaggccacc ugcugcugaa gcagggcaag      360

cuggacgagg ccgaggacga cuucaagaag gugcugaaga gcaaccccag cgagaacgag      420

gagaaggagg cccagagcca gcugaucaag agcgacgaga ugcagagacu gagaagccag      480

gcccugaacg ccuucggcag cggcgacuac accgccgcca ucgccuuccu ggacaagauc      540

cuggaggugu gcguguggga cgccgagcug agagagcuga gagccgagug cuucaucaag      600

gagggcgagc ccagaaaggc caucagcgac cugaaggccg ccagcaagcu gaagaacgac      660

aacaccgagg ccuucuacaa gaucagcacc cuguacuacc agcugggcga ccacgagcug      720

agccugagcg aggugagaga gugccugaag cuggaccagg accacaagag augcuucgcc      780

cacuacaagc aggugaagaa gcugaacaag cugaucgaga gcgccgagga gcugaucaga      840

gacggcagau acaccgacgc caccagcaag uacgagagcg ugaugaagac cgagcccagc      900

aucgccgagu acaccgugag aagcaaggag agaaucugcc acugcuucag caaggacgag      960

aagcccgugg aggccaucag agugugcagc gaggugcugc agauggagcc cgacaacgug     1020

aacgcccuga aggacagagc cgaggccuac cugaucgagg agauguacga cgaggccauc     1080

caggacuacg agaccgccca ggagcacaac gagaacgacc agcagaucag agagggccug     1140

gagaaggccc agagacugcu gaagcagagc cagaagagag acuacuacaa gauccugggc     1200

gugaagagaa acgccaagaa gcaggagauc aucaaggccu acagaaagcu ggcccugcag     1260

uggcaccccg acaacuucca gaacgaggag gagaagaaga aggccgagaa gaaguucauc     1320

gacaucgccg ccgccaagga ggugcugagc gaccccgaga ugagaaagaa guucgacgac     1380

ggcgaggacc cccuggacgc cgagagccag cagggcggcg gcggcaaccc cuuccacaga     1440

agcuggaaca gcuggcaggg cuucaacccc uucagcagcg gcggccccuu cagauucaag     1500

uuccacuuca acuga                                                      1515


<210>  8429
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC3__Homo_sapiens__AAC50502

<400>  8429
augguggccc ccggcagcgu caccuccaga cuggggucug uuuucccuuu ucuccuggug       60

cuuguggacc ugcaguacga gggagcugaa ugcggcguca acgccgaugu ggagaagcac      120

cucgaacugg ggaaaaagcu gcuugcggcu ggacaacucg ccgacgcccu gagccaguuc      180

caugcugccg uugauggcga cccggauaau uauaucgcuu acuaucggcg cgccacagug      240

uuucuggcga uggggaaauc caaggccgcu cuccccgacc ugacgaaagu cauucagcuu      300

aagauggauu ucaccgccgc uagacugcag cggggacacc uccugcuuaa gcaaggcaaa      360

cuggacgagg ccgaagauga cuuuaagaaa gugcucaagu cuaacccuag cgagaaugag      420

gaaaaagagg cgcaguccca gcugaucaag ucugaugaaa ugcagcgccu gagaagccaa      480

gcccucaacg cuuucggcuc cggggacuac acagccgcua uugccuuucu ggauaagauc      540

cuugagguuu guguguggga cgccgagcug cgggaacucc gcgcugagug cuucauuaaa      600

gaaggagagc ccagaaaggc gaucagcgac cugaaagccg cuucuaaacu uaaaaaugau      660

aacaccgaag ccuuuuauaa gaucuccaca cuguacuauc agcucggcga ccaugagcug      720

agccugucug agguccggga augucucaaa cuggaucagg accacaagcg cugcuucgcc      780

cauuacaaac aggugaagaa acuuaauaag cugauugagu ccgcugagga acucaucaga      840

gaugggcggu acaccgacgc cacaagcaag uaugaaucug ugaugaaaac cgagccuucc      900

auugcggagu acacgguccg cagcaaggaa agaaucuguc acugcuuuuc caaggaugag      960

aaacccguug aagcuauucg gguguguucu gaggugcugc aaauggaacc ugacaacguc     1020

aaugcccuua aggaucgcgc cgaggcuuau cugaucgagg aaauguacga cgaggccauu     1080

caggauuaug aaaccgcuca ggagcacaac gagaaugacc aacagaucag agaaggacuc     1140

gagaaagccc agcggcugcu gaagcagagc caaaagagag acuacuauaa gauccucggc     1200

gugaagcgca acgcgaaaaa gcaggaaauu aucaaagccu accggaagcu ggcccuucag     1260

uggcauccgg auaauuucca gaacgaggaa gagaaaaaga aggcugagaa aaaguuuauu     1320

gacaucgcug ccgcgaaaga aguucugucc gaucccgaga ugagaaagaa auucgacgau     1380

ggggaagacc cucucgaugc cgagagccaa cagggaggcg gcgggaaucc cuuccaccgc     1440

ucuuggaacu ccuggcaggg auuuaacccu uucagcucug gcgggcccuu ucgguucaag     1500

uuucauuuca auuga                                                      1515


<210>  8430
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC4__Homo_sapiens__Q9NNZ3

<400>  8430

Met Pro Pro Leu Leu Pro Leu Arg Leu Cys Arg Leu Trp Pro Arg Asn 
1               5                   10                  15      


Pro Pro Ser Arg Leu Leu Gly Ala Ala Ala Gly Gln Arg Ser Arg Pro 
            20                  25                  30          


Ser Thr Tyr Tyr Glu Leu Leu Gly Val His Pro Gly Ala Ser Thr Glu 
        35                  40                  45              


Glu Val Lys Arg Ala Phe Phe Ser Lys Ser Lys Glu Leu His Pro Asp 
    50                  55                  60                  


Arg Asp Pro Gly Asn Pro Ser Leu His Ser Arg Phe Val Glu Leu Ser 
65                  70                  75                  80  


Glu Ala Tyr Arg Val Leu Ser Arg Glu Gln Ser Arg Arg Ser Tyr Asp 
                85                  90                  95      


Asp Gln Leu Arg Ser Gly Ser Pro Pro Lys Ser Pro Arg Thr Thr Val 
            100                 105                 110         


His Asp Lys Ser Ala His Gln Thr His Ser Ser Trp Thr Pro Pro Asn 
        115                 120                 125             


Ala Gln Tyr Trp Ser Gln Phe His Ser Val Arg Pro Gln Gly Pro Gln 
    130                 135                 140                 


Leu Arg Gln Gln Gln His Lys Gln Asn Lys Gln Val Leu Gly Tyr Cys 
145                 150                 155                 160 


Leu Leu Leu Met Leu Ala Gly Met Gly Leu His Tyr Ile Ala Phe Arg 
                165                 170                 175     


Lys Val Lys Gln Met His Leu Asn Phe Met Asp Glu Lys Asp Arg Ile 
            180                 185                 190         


Ile Thr Ala Phe Tyr Asn Glu Ala Arg Ala Arg Ala Arg Ala Asn Arg 
        195                 200                 205             


Gly Ile Leu Gln Gln Glu Arg Gln Arg Leu Gly Gln Arg Gln Pro Pro 
    210                 215                 220                 


Pro Ser Glu Pro Thr Gln Gly Pro Glu Ile Val Pro Arg Gly Ala Gly 
225                 230                 235                 240 


Pro 
    


<210>  8431
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC4__Homo_sapiens__AAF97845

<400>  8431
augccgcccu uacugccccu gcgccugugc cggcuguggc cccgcaaccc ucccucccgg       60

cuccucggag cggccgccgg gcagcggucc agacccagua cuuauuauga acuguugggg      120

gugcauccug gugccagcac ugaggaaguu aaacgagcuu ucuucuccaa guccaaagag      180

cugcacccag accgggaccc ugggaaccca agccugcaca gccgcuuugu ggagcugagc      240

gaggcauacc gugugcucag ccgugagcag agccgccgca gcuaugauga ccagcuccgc      300

ucagguaguc ccccaaaguc uccacgaacc acaguccaug acaagucugc ccaccaaaca      360

cacagcuccu ggacaccccc caacgcacag uacugguccc aguuucacag cgugaggcca      420

caggggcccc aguugaggca gcagcaacac aaacaaaaca aacaagugcu gggguacugc      480

cuccuccuca ugcuggcggg caugggccug cacuacauug ccuucaggaa ggugaagcag      540

augcaccuua acuucaugga ugaaaaggau cggaucauca cagccuucua caacgaagcc      600

cgggcacggg ccagggccaa cagaggcauc cuucagcagg agcgacaacg gcuagggcag      660

cggcagccgc caccauccga gccaacccaa ggccccgaga ucgugccccg gggcgccggc      720

cccuga                                                                 726


<210>  8432
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC4__Homo_sapiens__AAF97845

<400>  8432
augcccccgc ugcucccccu gcgccugugc cggcucuggc cccgcaaccc gcccagccgg       60

cugcugggcg ccgccgcggg gcagcgcucc cggcccagca ccuacuacga gcuccugggc      120

gugcaccccg gggccuccac cgaggagguc aagcgcgccu ucuucagcaa guccaaggag      180

cugcaccccg accgggaccc gggcaacccc agccuccacu cccgcuucgu ggagcugagc      240

gaggccuacc gggugcuguc ccgcgagcag agccggcgcu ccuacgacga ccagcuccgg      300

agcggguccc cgcccaagag cccccgcacg accguccacg acaaguccgc ccaccagacc      360

cacagcuccu ggaccccgcc caacgcgcag uacuggagcc aguuccacuc cgugcggccc      420

cagggccccc agcugcgcca gcagcagcac aagcagaaca agcagguccu gggcuacugc      480

cuccugcuga ugcucgccgg gaugggccug cacuacaucg ccuuccggaa ggugaagcag      540

augcaccuga acuucaugga cgagaaggac cgcaucauca cggccuucua caacgaggcg      600

cgggcccgcg cccgggccaa ccgcgggauc cuccagcagg agcgccagcg gcugggccag      660

cgccagcccc cgcccagcga gcccacccag gggcccgaga ucgugccccg gggcgccggc      720

cccuga                                                                 726


<210>  8433
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC4__Homo_sapiens__AAF97845

<400>  8433
augccccccc uccucccccu ccgccucugc cgccucuggc cccgcaaccc ccccucccgc       60

cuccucggcg ccgccgccgg ccagcgcucc cgccccucca ccuacuacga gcuccucggc      120

guccaccccg gcgccuccac cgaggagguc aagcgcgccu ucuucuccaa guccaaggag      180

cuccaccccg accgcgaccc cggcaacccc ucccuccacu cccgcuucgu cgagcucucc      240

gaggccuacc gcguccucuc ccgcgagcag ucccgccgcu ccuacgacga ccagcuccgc      300

uccggcuccc cccccaaguc cccccgcacc accguccacg acaaguccgc ccaccagacc      360

cacuccuccu ggaccccccc caacgcccag uacugguccc aguuccacuc cguccgcccc      420

cagggccccc agcuccgcca gcagcagcac aagcagaaca agcagguccu cggcuacugc      480

cuccuccuca ugcucgccgg caugggccuc cacuacaucg ccuuccgcaa ggucaagcag      540

augcaccuca acuucaugga cgagaaggac cgcaucauca ccgccuucua caacgaggcc      600

cgcgcccgcg cccgcgccaa ccgcggcauc cuccagcagg agcgccagcg ccucggccag      660

cgccagcccc cccccuccga gcccacccag ggccccgaga ucgucccccg cggcgccggc      720

cccuga                                                                 726


<210>  8434
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC4__Homo_sapiens__AAF97845

<400>  8434
augcccccuc ugcucccacu uaggcugugc agguuguggc cgcggaaucc cccuagccgc       60

uuacugggcg ccgcugcagg gcagcgaucc cguccaucua ccuacuauga gcuacucgga      120

gugcaccccg gugccucaac agaagagguc aagagagcgu ucuuuaguaa aagcaaggaa      180

cugcauccug acagggaucc aggcaacccc ucccuucacu cucgguucgu ugagcugucg      240

gaggcuuacc gcguguuguc aagagaacaa agcaggcgga guuaugacga ucagcuccgc      300

uccgggucuc cuccaaaaag cccgcgaacu acgguacaug acaaguccgc ccaccagacc      360

cauucaaguu ggacaccccc uaacgcacag uacuggagcc aauuucacuc ugugagacca      420

cagggacccc agcugaggca gcaacagcac aaacagaaua agcagguccu gggcuauugu      480

cucuuacuga ugcuugccgg uaugggguug cauuacaucg cuuuccggaa ggugaaacaa      540

augcaccuga acuuuaugga ugagaaggac cguauuauaa cugcauucua uaaugaagcc      600

cgcgcuagag ccagggcgaa ccggggaauc cuacagcagg agcgacaacg ccucggccag      660

agacagccuc cacccuccga accgacccag ggcccugaga uuguucccag aggggcagga      720

ccauga                                                                 726


<210>  8435
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC4__Homo_sapiens__AAF97845

<400>  8435
augccccccc ugcugccccu gagacugugc agacuguggc ccagaaaccc ccccagcaga       60

cugcugggcg ccgccgccgg ccagagaagc agacccagca ccuacuacga gcugcugggc      120

gugcaccccg gcgccagcac cgaggaggug aagagagccu ucuucagcaa gagcaaggag      180

cugcaccccg acagagaccc cggcaacccc agccugcaca gcagauucgu ggagcugagc      240

gaggccuaca gagugcugag cagagagcag agcagaagaa gcuacgacga ccagcugaga      300

agcggcagcc cccccaagag ccccagaacc accgugcacg acaagagcgc ccaccagacc      360

cacagcagcu ggaccccccc caacgcccag uacuggagcc aguuccacag cgugagaccc      420

cagggccccc agcugagaca gcagcagcac aagcagaaca agcaggugcu gggcuacugc      480

cugcugcuga ugcuggccgg caugggccug cacuacaucg ccuucagaaa ggugaagcag      540

augcaccuga acuucaugga cgagaaggac agaaucauca ccgccuucua caacgaggcc      600

agagccagag ccagagccaa cagaggcauc cugcagcagg agagacagag acugggccag      660

agacagcccc cccccagcga gcccacccag ggccccgaga ucgugcccag aggcgccggc      720

cccuga                                                                 726


<210>  8436
<211>  726
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC4__Homo_sapiens__AAF97845

<400>  8436
augcccccuc ugcucccgcu gagacuuugc cggcuguggc cccgcaaccc ucccagcaga       60

cuccugggcg ccgcugccgg gcagcggucc cgcccuucua ccuacuauga gcuucuggga      120

gugcaccccg gcgcgagcac agaagagguc aagagagcuu ucuuuuccaa aucuaaggaa      180

cuccauccug accgggaucc ggggaauccc agccugcacu cccgcuucgu ugagcugucu      240

gaagccuaca gagugcucag ccgggagcaa ucccgcagaa gcuaugacga ucagcugcgg      300

ucuggauccc cucccaaaag cccucgcacg accgugcaug acaagucugc ccaccagaca      360

cauuccagcu ggacaccccc gaacgcucag uacuggucuc aauuucacuc cgucagaccu      420

cagggccccc agcuucggca gcaacagcac aaacagaaua aacaggugcu gggguauugu      480

cuccugcuua ugcuggccgg aaugggccuc cauuacaucg cuuuccgcaa gguuaagcaa      540

augcaccuga acuuuaugga ugagaaggac agaauuauca ccgccuucua uaaugaagcg      600

cgggccagag cucgcgccaa ccggggcauu cugcagcagg agagacaacg ccucgggcag      660

cggcagccuc cucccagcga acccacccag ggaccggaga ucgugcccag aggcgcuggg      720

ccuuga                                                                 726


<210>  8437
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC5__Homo_sapiens__Q9H3Z4

<400>  8437

Met Ala Asp Gln Arg Gln Arg Ser Leu Ser Thr Ser Gly Glu Ser Leu 
1               5                   10                  15      


Tyr His Val Leu Gly Leu Asp Lys Asn Ala Thr Ser Asp Asp Ile Lys 
            20                  25                  30          


Lys Ser Tyr Arg Lys Leu Ala Leu Lys Tyr His Pro Asp Lys Asn Pro 
        35                  40                  45              


Asp Asn Pro Glu Ala Ala Asp Lys Phe Lys Glu Ile Asn Asn Ala His 
    50                  55                  60                  


Ala Ile Leu Thr Asp Ala Thr Lys Arg Asn Ile Tyr Asp Lys Tyr Gly 
65                  70                  75                  80  


Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Glu Glu Asn Val Asn 
                85                  90                  95      


Thr Tyr Phe Val Leu Ser Ser Trp Trp Ala Lys Ala Leu Phe Val Phe 
            100                 105                 110         


Cys Gly Leu Leu Thr Cys Cys Tyr Cys Cys Cys Cys Leu Cys Cys Cys 
        115                 120                 125             


Phe Asn Cys Cys Cys Gly Lys Cys Lys Pro Lys Ala Pro Glu Gly Glu 
    130                 135                 140                 


Glu Thr Glu Phe Tyr Val Ser Pro Glu Asp Leu Glu Ala Gln Leu Gln 
145                 150                 155                 160 


Ser Asp Glu Arg Glu Ala Thr Asp Thr Pro Ile Val Ile Gln Pro Ala 
                165                 170                 175     


Ser Ala Thr Glu Thr Thr Gln Leu Thr Ala Asp Ser His Pro Ser Tyr 
            180                 185                 190         


His Thr Asp Gly Phe Asn 
        195             


<210>  8438
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC5__Homo_sapiens__AAH53642

<400>  8438
auggcagacc agagacagcg cucacugucu accucugggg agucauugua ccacguccuu       60

ggguuggaca agaacgcaac cucagaugac auuaaaaagu ccuaucggaa gcuugccuug      120

aaauaucacc ccgacaagaa ccccgacaac ccggaggccg cggacaaguu uaaggagauc      180

aacaacgcgc acgccauccu cacggacgcc acaaaaagga acaucuacga caaguacggc      240

ucgcuggguc ucuacguggc cgagcaguuu ggggaagaga acgugaacac cuacuucgug      300

cuguccagcu ggugggccaa ggcccuguuu gucuucugcg gccuccucac gugcugcuac      360

ugcugcugcu gucugugcug cugcuucaac ugcugcugcg ggaaguguaa gcccaaggcg      420

ccugaaggcg aggagacgga guucuacgug ucccccgagg aucuggaggc acagcugcag      480

ucugacgaga gggaggccac agacacgccg aucgucauac agccggcauc cgccaccgag      540

accacccagc ucacagccga cucccacccc agcuaccaca cugacggguu caacuaa         597


<210>  8439
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC5__Homo_sapiens__AAH53642

<400>  8439
auggccgacc agcgccagcg gagccugucc accagcggcg agucccucua ccacgugcug       60

gggcuggaca agaacgccac cagcgacgac aucaagaagu ccuaccgcaa gcucgcgcug      120

aaguaccacc ccgacaagaa cccggacaac cccgaggccg ccgacaaguu caaggagauc      180

aacaacgccc acgccauccu gacggacgcg accaagcgga acaucuacga caaguacggc      240

agccucgggc uguacgucgc cgagcaguuc ggcgaggaga acgugaacac cuacuucgug      300

cuguccagcu ggugggccaa ggcccucuuc gucuucugcg ggcugcugac cugcugcuac      360

ugcugcugcu gccucugcug cugcuucaac ugcugcugcg gcaagugcaa gcccaaggcg      420

cccgagggcg aggagacgga guucuacgug uccccggagg accuggaggc ccagcugcag      480

agcgacgagc gcgaggccac cgacaccccc aucgugaucc agcccgccuc cgccaccgag      540

acgacccagc ucaccgcgga cagccacccc uccuaccaca ccgacggguu caacuga         597


<210>  8440
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC5__Homo_sapiens__AAH53642

<400>  8440
auggccgacc agcgccagcg cucccucucc accuccggcg agucccucua ccacguccuc       60

ggccucgaca agaacgccac cuccgacgac aucaagaagu ccuaccgcaa gcucgcccuc      120

aaguaccacc ccgacaagaa ccccgacaac cccgaggccg ccgacaaguu caaggagauc      180

aacaacgccc acgccauccu caccgacgcc accaagcgca acaucuacga caaguacggc      240

ucccucggcc ucuacgucgc cgagcaguuc ggcgaggaga acgucaacac cuacuucguc      300

cucuccuccu ggugggccaa ggcccucuuc gucuucugcg gccuccucac cugcugcuac      360

ugcugcugcu gccucugcug cugcuucaac ugcugcugcg gcaagugcaa gcccaaggcc      420

cccgagggcg aggagaccga guucuacguc ucccccgagg accucgaggc ccagcuccag      480

uccgacgagc gcgaggccac cgacaccccc aucgucaucc agcccgccuc cgccaccgag      540

accacccagc ucaccgccga cucccacccc uccuaccaca ccgacggcuu caacuga         597


<210>  8441
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC5__Homo_sapiens__AAH53642

<400>  8441
auggccgacc agagacaaag gagccugucc accucuggcg agucacucua ccacgugcuu       60

gggcuggaua agaacgcuac aagugacgau aucaaaaaga gcuaucggaa auuggcauua      120

aaguaccauc ccgacaaaaa uccugauaac ccagaagccg cggacaaguu caaggagauu      180

aauaacgcuc acgccauacu gacugaugca acgaaacgca auaucuauga caaguacgga      240

ucccuagguc ucuaugucgc cgaacaguuu ggcgaggaaa acguuaauac cuacuucgug      300

cugucuucgu ggugggcuaa agcacuuuuu guauucugcg ggcuguugac auguugcuau      360

uguugcuguu gccucuguug cuguuuuaac ugcuguugcg gaaagugcaa accgaaggcc      420

cccgagggcg aggaaacuga guucuacgug ucaccugaag aucuggaggc ucagcugcag      480

agcgacgagc gagaagccac cgauacacca auugucaucc aacccgcgag ugcaaccgag      540

acuacacagc ucaccgccga cucccauccu ucuuaccaca cggaugguuu uaauuga         597


<210>  8442
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC5__Homo_sapiens__AAH53642

<400>  8442
auggccgacc agagacagag aagccugagc accagcggcg agagccugua ccacgugcug       60

ggccuggaca agaacgccac cagcgacgac aucaagaaga gcuacagaaa gcuggcccug      120

aaguaccacc ccgacaagaa ccccgacaac cccgaggccg ccgacaaguu caaggagauc      180

aacaacgccc acgccauccu gaccgacgcc accaagagaa acaucuacga caaguacggc      240

agccugggcc uguacguggc cgagcaguuc ggcgaggaga acgugaacac cuacuucgug      300

cugagcagcu ggugggccaa ggcccuguuc guguucugcg gccugcugac cugcugcuac      360

ugcugcugcu gccugugcug cugcuucaac ugcugcugcg gcaagugcaa gcccaaggcc      420

cccgagggcg aggagaccga guucuacgug agccccgagg accuggaggc ccagcugcag      480

agcgacgaga gagaggccac cgacaccccc aucgugaucc agcccgccag cgccaccgag      540

accacccagc ugaccgccga cagccacccc agcuaccaca ccgacggcuu caacuga         597


<210>  8443
<211>  597
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC5__Homo_sapiens__AAH53642

<400>  8443
auggccgacc agagacaacg gagccugucc accucuggcg agagccucua ccacgugcug       60

gggcuugaua agaacgcuac auccgacgau aucaaaaagu cuuaucgcaa acuggcccuc      120

aaguaccauc ccgacaaaaa uccugauaac ccggaagcgg cugacaaguu caaggagauu      180

aauaacgccc acgccauccu gacggaugcu accaaaagaa auauuuauga caaguacgga      240

agccuuggcc uguaugucgc cgaacaguuu ggggaggaaa acguuaauac auacuucgug      300

cucuccucuu ggugggcuaa agcccuguuu guguucugcg gacugcucac cuguugcuau      360

uguugcuguu gccuguguug cuguuuuaac ugcuguugcg gcaagugcaa acccaaggcg      420

ccugaggggg aggaaacaga guucuacguc agccccgaag aucuugaggc ccagcugcag      480

uccgacgagc gggaagcuac cgauacaccu aucgugauuc aacccgccag cgcuaccgag      540

acgacccagc ucacagccga cucucauccu uccuaccaca ccgauggauu uaauuga         597


<210>  8444
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC7__Homo_sapiens__Q99615

<400>  8444

Met Ala Ala Ala Ala Glu Cys Asp Val Val Met Ala Ala Thr Glu Pro 
1               5                   10                  15      


Glu Leu Leu Asp Asp Gln Glu Ala Lys Arg Glu Ala Glu Thr Phe Lys 
            20                  25                  30          


Glu Gln Gly Asn Ala Tyr Tyr Ala Lys Lys Asp Tyr Asn Glu Ala Tyr 
        35                  40                  45              


Asn Tyr Tyr Thr Lys Ala Ile Asp Met Cys Pro Lys Asn Ala Ser Tyr 
    50                  55                  60                  


Tyr Gly Asn Arg Ala Ala Thr Leu Met Met Leu Gly Arg Phe Arg Glu 
65                  70                  75                  80  


Ala Leu Gly Asp Ala Gln Gln Ser Val Arg Leu Asp Asp Ser Phe Val 
                85                  90                  95      


Arg Gly His Leu Arg Glu Gly Lys Cys His Leu Ser Leu Gly Asn Ala 
            100                 105                 110         


Met Ala Ala Cys Arg Ser Phe Gln Arg Ala Leu Glu Leu Asp His Lys 
        115                 120                 125             


Asn Ala Gln Ala Gln Gln Glu Phe Lys Asn Ala Asn Ala Val Met Glu 
    130                 135                 140                 


Tyr Glu Lys Ile Ala Glu Thr Asp Phe Glu Lys Arg Asp Phe Arg Lys 
145                 150                 155                 160 


Val Val Phe Cys Met Asp Arg Ala Leu Glu Phe Ala Pro Ala Cys His 
                165                 170                 175     


Arg Phe Lys Ile Leu Lys Ala Glu Cys Leu Ala Met Leu Gly Arg Tyr 
            180                 185                 190         


Pro Glu Ala Gln Ser Val Ala Ser Asp Ile Leu Arg Met Asp Ser Thr 
        195                 200                 205             


Asn Ala Asp Ala Leu Tyr Val Arg Gly Leu Cys Leu Tyr Tyr Glu Asp 
    210                 215                 220                 


Cys Ile Glu Lys Ala Val Gln Phe Phe Val Gln Ala Leu Arg Met Ala 
225                 230                 235                 240 


Pro Asp His Glu Lys Ala Cys Ile Ala Cys Arg Asn Ala Lys Ala Leu 
                245                 250                 255     


Lys Ala Lys Lys Glu Asp Gly Asn Lys Ala Phe Lys Glu Gly Asn Tyr 
            260                 265                 270         


Lys Leu Ala Tyr Glu Leu Tyr Thr Glu Ala Leu Gly Ile Asp Pro Asn 
        275                 280                 285             


Asn Ile Lys Thr Asn Ala Lys Leu Tyr Cys Asn Arg Gly Thr Val Asn 
    290                 295                 300                 


Ser Lys Leu Arg Lys Leu Asp Asp Ala Ile Glu Asp Cys Thr Asn Ala 
305                 310                 315                 320 


Val Lys Leu Asp Asp Thr Tyr Ile Lys Ala Tyr Leu Arg Arg Ala Gln 
                325                 330                 335     


Cys Tyr Met Asp Thr Glu Gln Tyr Glu Glu Ala Val Arg Asp Tyr Glu 
            340                 345                 350         


Lys Val Tyr Gln Thr Glu Lys Thr Lys Glu His Lys Gln Leu Leu Lys 
        355                 360                 365             


Asn Ala Gln Leu Glu Leu Lys Lys Ser Lys Arg Lys Asp Tyr Tyr Lys 
    370                 375                 380                 


Ile Leu Gly Val Asp Lys Asn Ala Ser Glu Asp Glu Ile Lys Lys Ala 
385                 390                 395                 400 


Tyr Arg Lys Arg Ala Leu Met His His Pro Asp Arg His Ser Gly Ala 
                405                 410                 415     


Ser Ala Glu Val Gln Lys Glu Glu Glu Lys Lys Phe Lys Glu Val Gly 
            420                 425                 430         


Glu Ala Phe Thr Ile Leu Ser Asp Pro Lys Lys Lys Thr Arg Tyr Asp 
        435                 440                 445             


Ser Gly Gln Asp Leu Asp Glu Glu Gly Met Asn Met Gly Asp Phe Asp 
    450                 455                 460                 


Pro Asn Asn Ile Phe Lys Ala Phe Phe Gly Gly Pro Gly Gly Phe Ser 
465                 470                 475                 480 


Phe Glu Ala Ser Gly Pro Gly Asn Phe Phe Phe Gln Phe Gly 
                485                 490                 


<210>  8445
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC7__Homo_sapiens__AAH11837

<400>  8445
auggcggcug ccgcggagug cgauguggua auggcggcga ccgagccgga gcugcucgac       60

gaccaagagg cgaagaggga agcagagacu uucaaggaac aaggaaaugc auacuaugcc      120

aagaaagauu acaaugaagc uuauaauuau uauacaaaag ccauagauau guguccuaaa      180

aaugcuagcu auuaugguaa ucgagcagcc accuugauga ugcuuggaag guuccgggaa      240

gcucuuggag augcacaaca gucagugagg uuggaugaca guuuuguccg gggacaucua      300

cgagagggca agugccaccu cucucugggg aaugccaugg cagcaugucg cagcuuccag      360

agagcccuag aacuggauca uaaaaaugcu caggcacaac aagaguucaa gaaugcuaau      420

gcagucaugg aauaugagaa aauagcagaa acagauuuug agaagcgaga uuuucggaag      480

guuguuuucu gcauggaccg ugcccuagaa uuugccccug ccugccaucg cuucaaaauc      540

cucaaggcag aauguuuagc aaugcugggu cguuauccag aagcacaguc uguggcuagu      600

gacauucuac gaauggauuc caccaaugca gaugcucugu auguacgagg ucuuugccuu      660

uauuacgaag auuguauuga gaaggcaguu caguuuuucg uacaggcucu caggauggcu      720

ccugaccacg agaaggccug cauugccugc agaaaugcca aagcacucaa agcaaagaaa      780

gaagauggga auaaagcauu uaaggaagga aauuacaaac uagcauauga acuguacaca      840

gaagcccugg ggauagaccc caacaauaua aaaacaaaug cuaaacucua cuguaaucgg      900

gguacgguua auuccaagcu uaggaaacua gaugaugcaa uagaagacug cacaaaugca      960

gugaagcuug augacacuua cauaaaagcc uacuugagaa gagcucagug uuacauggac     1020

acagaacagu augaagaagc aguacgagac uaugaaaaag uauaccagac agagaaaaca     1080

aaagaacaca aacagcuccu aaaaaaugcg cagcuggaac ugaagaagag uaagaggaaa     1140

gauuacuaca agauucuagg aguggacaag aaugccucug aggacgagau caagaaagcu     1200

uaucggaaac gggccuugau gcaccaucca gaucggcaua guggagccag ugcugagguu     1260

cagaaggagg aggagaagaa guucaaggaa guuggagagg ccuuuacuau ccucucugau     1320

cccaagaaaa agacucgcua ugacagugga caggaccuag augaggaggg caugaauaug     1380

ggugauuuug auccaaacaa uaucuucaag gcauucuuug gcgguccugg cggcuucagc     1440

uuugaagcau cugguccagg gaauuucuuu uuucaauuug gcuaa                     1485


<210>  8446
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC7__Homo_sapiens__AAH11837

<400>  8446
auggccgccg cggccgagug cgacgugguc auggccgcca ccgagcccga gcugcucgac       60

gaccaggagg ccaagcgcga ggcggagacc uucaaggagc agggcaacgc cuacuacgcc      120

aagaaggacu acaacgaggc cuacaacuac uacacgaagg cgaucgacau gugcccgaag      180

aacgccagcu acuacgggaa ccgggccgcc acccugauga ugcugggccg cuuccgggag      240

gcccucgggg acgcgcagca guccgugcgc cuggacgaca gcuucgugcg gggccaccuc      300

cgcgagggga agugccaccu gucccugggc aacgccaugg ccgccugccg gagcuuccag      360

cgcgcccugg agcucgacca caagaacgcg caggcccagc aggaguucaa gaacgccaac      420

gccgucaugg aguacgagaa gaucgccgag accgacuucg agaagcggga cuuccgcaag      480

gugguguucu gcauggaccg ggcgcuggag uucgcccccg ccugccaccg cuucaagauc      540

cugaaggccg agugccucgc caugcugggc cgguaccccg aggcgcaguc cgucgccagc      600

gacauccugc gcauggacuc caccaacgcc gacgcccucu acgugcgggg gcugugccug      660

uacuacgagg acugcaucga gaaggcggug caguucuucg uccaggcccu ccgcauggcc      720

cccgaccacg agaaggccug caucgccugc cggaacgcga aggcccugaa ggccaagaag      780

gaggacggca acaaggccuu caaggagggg aacuacaagc uggccuacga gcucuacacg      840

gaggcgcugg gcaucgaccc gaacaacauc aagaccaacg ccaagcugua cugcaaccgc      900

gggaccguga acagcaagcu ccggaagcug gacgacgcca ucgaggacug caccaacgcc      960

gugaagcugg acgacacgua caucaaggcc uaccuccgcc gggcgcagug cuacauggac     1020

accgagcagu acgaggaggc cguccgcgac uacgagaagg uguaccagac cgagaagacc     1080

aaggagcaca agcagcugcu gaagaacgcc cagcucgagc ugaagaaguc caagcgcaag     1140

gacuacuaca agauccuggg cguggacaag aacgccagcg aggacgagau caagaaggcg     1200

uaccggaagc gcgcccucau gcaccacccc gaccggcacu ccggcgccag cgccgagguc     1260

cagaaggagg aggagaagaa guucaaggag gugggggagg ccuucacgau ccuguccgac     1320

cccaagaaga agacccgcua cgacagcggc caggaccugg acgaggaggg gaugaacaug     1380

ggcgacuucg accccaacaa caucuucaag gcguucuucg gcgggccggg cggguucucc     1440

uucgaggcca gcggccccgg gaacuucuuc uuccaguucg gcuga                     1485


<210>  8447
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC7__Homo_sapiens__AAH11837

<400>  8447
auggccgccg ccgccgagug cgacgucguc auggccgcca ccgagcccga gcuccucgac       60

gaccaggagg ccaagcgcga ggccgagacc uucaaggagc agggcaacgc cuacuacgcc      120

aagaaggacu acaacgaggc cuacaacuac uacaccaagg ccaucgacau gugccccaag      180

aacgccuccu acuacggcaa ccgcgccgcc acccucauga ugcucggccg cuuccgcgag      240

gcccucggcg acgcccagca guccguccgc cucgacgacu ccuucguccg cggccaccuc      300

cgcgagggca agugccaccu cucccucggc aacgccaugg ccgccugccg cuccuuccag      360

cgcgcccucg agcucgacca caagaacgcc caggcccagc aggaguucaa gaacgccaac      420

gccgucaugg aguacgagaa gaucgccgag accgacuucg agaagcgcga cuuccgcaag      480

gucgucuucu gcauggaccg cgcccucgag uucgcccccg ccugccaccg cuucaagauc      540

cucaaggccg agugccucgc caugcucggc cgcuaccccg aggcccaguc cgucgccucc      600

gacauccucc gcauggacuc caccaacgcc gacgcccucu acguccgcgg ccucugccuc      660

uacuacgagg acugcaucga gaaggccguc caguucuucg uccaggcccu ccgcauggcc      720

cccgaccacg agaaggccug caucgccugc cgcaacgcca aggcccucaa ggccaagaag      780

gaggacggca acaaggccuu caaggagggc aacuacaagc ucgccuacga gcucuacacc      840

gaggcccucg gcaucgaccc caacaacauc aagaccaacg ccaagcucua cugcaaccgc      900

ggcaccguca acuccaagcu ccgcaagcuc gacgacgcca ucgaggacug caccaacgcc      960

gucaagcucg acgacaccua caucaaggcc uaccuccgcc gcgcccagug cuacauggac     1020

accgagcagu acgaggaggc cguccgcgac uacgagaagg ucuaccagac cgagaagacc     1080

aaggagcaca agcagcuccu caagaacgcc cagcucgagc ucaagaaguc caagcgcaag     1140

gacuacuaca agauccucgg cgucgacaag aacgccuccg aggacgagau caagaaggcc     1200

uaccgcaagc gcgcccucau gcaccacccc gaccgccacu ccggcgccuc cgccgagguc     1260

cagaaggagg aggagaagaa guucaaggag gucggcgagg ccuucaccau ccucuccgac     1320

cccaagaaga agacccgcua cgacuccggc caggaccucg acgaggaggg caugaacaug     1380

ggcgacuucg accccaacaa caucuucaag gccuucuucg gcggccccgg cggcuucucc     1440

uucgaggccu ccggccccgg caacuucuuc uuccaguucg gcuga                     1485


<210>  8448
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC7__Homo_sapiens__AAH11837

<400>  8448
auggccgcug cagccgagug cgacgugguc auggcggcua ccgaacccga gcugcucgau       60

gaccaggaag ccaagagaga ggcagaaaca uucaaagagc aaggcaacgc cuacuaugcu      120

aagaaagauu acaaugaggc auauaacuac uauacuaagg ccaucgacau guguccuaaa      180

aaugcuagcu acuaugggaa cagggccgcg acgcuuauga ugcugggacg guuucgcgaa      240

gcauugggug augcccagca guccguucga uuagacgauu cuuucgugcg uggccaccug      300

agagagggga agugccaucu aucacucgga aaugcuaugg ccgcauguag gaguuuucag      360

cgggcucugg aacuugacca caagaacgcc caagcgcagc aggaguucaa aaaugccaac      420

gcaguaaugg aguacgaaaa gauugcugag accgauuuug aaaaacgcga cuucagaaag      480

guggucuuuu gcauggauag ggcccuggag uucgcuccag ccugucaucg guuuaaaaua      540

uugaaggcag aaugccucgc caugcugggc cgcuacccgg aggcucagag cguggcgucc      600

gacauccugc gaauggauuc uacaaaugca gacgcccucu auguuagagg uuuaugucug      660

uacuaugagg acugcauuga aaaggcugug caauucuuug uccaggcccu uaggauggca      720

cccgaucacg agaaagccug uaucgcuugc cggaacgcca aggcauugaa agcgaagaaa      780

gaagacggga auaaggcuuu caaagaggga aacuacaagc uggccuauga acuauacacu      840

gaggcacucg gcauugaucc uaauaacauc aagaccaaug ccaaacugua uuguaaccgu      900

ggcacaguga acucgaaacu ucgcaaacug gacgaugcua uagaggacug caccaaugcc      960

guaaaguugg augacacuua caucaaagca uaccucagaa gggcucagug cuauauggau     1020

acagaacagu acgaggaagc cguucgggac uaugagaagg uguaccaaac cgaaaagacg     1080

aaagagcaua agcagcuguu aaagaacgcg cagcuggagc ucaagaaauc aaagcgaaag     1140

gauuauuaca aaauucuugg ggucgacaag aaugccagcg aagacgagau caaaaaggcu     1200

uaucgcaaaa gagcacugau gcaccaccca gauaggcaua guggagccuc cgcugaagug     1260

caaaaggagg aggaaaagaa auuuaaggag gugggugaag ccuucacuau uuugucugac     1320

cccaaaaaga aaacccggua cgauagcggc caggaccuag augaggaagg gaugaacaug     1380

ggagacuucg auccuaauaa caucuuuaag gcauucuuug gcgguccagg gggauucucc     1440

uuugaggcgu caggccccgg caauuucuuu uuccaguuug gguga                     1485


<210>  8449
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC7__Homo_sapiens__AAH11837

<400>  8449
auggccgccg ccgccgagug cgacguggug auggccgcca ccgagcccga gcugcuggac       60

gaccaggagg ccaagagaga ggccgagacc uucaaggagc agggcaacgc cuacuacgcc      120

aagaaggacu acaacgaggc cuacaacuac uacaccaagg ccaucgacau gugccccaag      180

aacgccagcu acuacggcaa cagagccgcc acccugauga ugcugggcag auucagagag      240

gcccugggcg acgcccagca gagcgugaga cuggacgaca gcuucgugag aggccaccug      300

agagagggca agugccaccu gagccugggc aacgccaugg ccgccugcag aagcuuccag      360

agagcccugg agcuggacca caagaacgcc caggcccagc aggaguucaa gaacgccaac      420

gccgugaugg aguacgagaa gaucgccgag accgacuucg agaagagaga cuucagaaag      480

gugguguucu gcauggacag agcccuggag uucgcccccg ccugccacag auucaagauc      540

cugaaggccg agugccuggc caugcugggc agauaccccg aggcccagag cguggccagc      600

gacauccuga gaauggacag caccaacgcc gacgcccugu acgugagagg ccugugccug      660

uacuacgagg acugcaucga gaaggccgug caguucuucg ugcaggcccu gagaauggcc      720

cccgaccacg agaaggccug caucgccugc agaaacgcca aggcccugaa ggccaagaag      780

gaggacggca acaaggccuu caaggagggc aacuacaagc uggccuacga gcuguacacc      840

gaggcccugg gcaucgaccc caacaacauc aagaccaacg ccaagcugua cugcaacaga      900

ggcaccguga acagcaagcu gagaaagcug gacgacgcca ucgaggacug caccaacgcc      960

gugaagcugg acgacaccua caucaaggcc uaccugagaa gagcccagug cuacauggac     1020

accgagcagu acgaggaggc cgugagagac uacgagaagg uguaccagac cgagaagacc     1080

aaggagcaca agcagcugcu gaagaacgcc cagcuggagc ugaagaagag caagagaaag     1140

gacuacuaca agauccuggg cguggacaag aacgccagcg aggacgagau caagaaggcc     1200

uacagaaaga gagcccugau gcaccacccc gacagacaca gcggcgccag cgccgaggug     1260

cagaaggagg aggagaagaa guucaaggag gugggcgagg ccuucaccau ccugagcgac     1320

cccaagaaga agaccagaua cgacagcggc caggaccugg acgaggaggg caugaacaug     1380

ggcgacuucg accccaacaa caucuucaag gccuucuucg gcggccccgg cggcuucagc     1440

uucgaggcca gcggccccgg caacuucuuc uuccaguucg gcuga                     1485


<210>  8450
<211>  1485
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC7__Homo_sapiens__AAH11837

<400>  8450
auggccgcug ccgcggagug cgacgugguc auggcugcca ccgaacccga gcugcucgau       60

gaccaggaag ccaagagaga ggcugaaaca uucaaagagc aaggcaacgc cuacuaugcu      120

aagaaagauu acaaugaggc cuauaacuac uauacgaagg cgaucgacau guguccuaaa      180

aaugccagcu acuaugggaa ccgggcugcc acccugauga ugcuuggacg cuuuagagaa      240

gcucugggcg augcccagca guccguucgg cucgacgauu cuuucgugcg cgggcaccug      300

agagagggaa agugccaucu uagccugggc aaugcgaugg ccgcuugucg guccuuucag      360

cgcgcccucg aacuggacca caagaacgcu caagcccagc aggaguucaa aaaugccaac      420

gcugugaugg aguacgaaaa gauugcggag acagauuuug aaaagagaga cuuccggaag      480

gucguguuuu gcauggaucg cgcccuggag uucgcuccgg ccugucauag auuuaaaauc      540

cucaaggccg aaugccuggc uaugcuuggg cgguaccccg aggcccaguc uguugcgagc      600

gacauucugc gcauggauuc caccaaugcu gacgcccucu augugagagg acugugucuu      660

uacuaugagg acugcaucga aaaggccguc caauucuuug ugcaggcucu gcggauggcc      720

ccugaucacg agaaggcuug uauugccugc cgcaacgcga aagcccucaa agcuaagaaa      780

gaagacggca auaaggccuu caaagagggc aacuacaagc uggcuuauga acuguacaca      840

gaggcccucg ggaucgaucc caauaacauc aagaccaaug cgaaacugua uuguaacaga      900

ggaacaguua acucuaaacu ucggaaacug gacgaugcca uugaggacug caccaaugcu      960

gugaagcucg augacacgua caucaaagcc uaccugagac gcgcucagug cuauauggau     1020

accgaacagu acgaggaagc cguccgggac uaugagaagg uguaccaaac agaaaagacc     1080

aaagagcaua agcagcuucu gaaaaacgcc cagcucgagc ugaagaaaag caagagaaag     1140

gauuauuaca aaauucuggg cguggacaag aaugcuuccg aagacgagau caaaaaggcg     1200

uaucgcaaac gggcccucau gcaccacccu gauagacaua gcggggcuuc ugccgaaguc     1260

caaaaggagg aggaaaagaa auuuaaggag guuggagaag ccuucacaau ucuguccgac     1320

cccaaaaaga aaacccgcua cgauagcggc caggaccuug augaggaagg gaugaacaug     1380

ggagacuucg auccuaauaa caucuuuaag gcuuucuuug gcggccccgg gggauucucu     1440

uuugaggccu ccggcccggg gaauuucuuu uuccaguuug gauga                     1485


<210>  8451
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC8__Homo_sapiens__O75937

<400>  8451

Met Ala Ala Ser Gly Glu Ser Gly Thr Ser Gly Gly Gly Gly Ser Thr 
1               5                   10                  15      


Glu Glu Ala Phe Met Thr Phe Tyr Ser Glu Val Lys Gln Ile Glu Lys 
            20                  25                  30          


Arg Asp Ser Val Leu Thr Ser Lys Asn Gln Ile Glu Arg Leu Thr Arg 
        35                  40                  45              


Pro Gly Ser Ser Tyr Phe Asn Leu Asn Pro Phe Glu Val Leu Gln Ile 
    50                  55                  60                  


Asp Pro Glu Val Thr Asp Glu Glu Ile Lys Lys Arg Phe Arg Gln Leu 
65                  70                  75                  80  


Ser Ile Leu Val His Pro Asp Lys Asn Gln Asp Asp Ala Asp Arg Ala 
                85                  90                  95      


Gln Lys Ala Phe Glu Ala Val Asp Lys Ala Tyr Lys Leu Leu Leu Asp 
            100                 105                 110         


Gln Glu Gln Lys Lys Arg Ala Leu Asp Val Ile Gln Ala Gly Lys Glu 
        115                 120                 125             


Tyr Val Glu His Thr Val Lys Glu Arg Lys Lys Gln Leu Lys Lys Glu 
    130                 135                 140                 


Gly Lys Pro Thr Ile Val Glu Glu Asp Asp Pro Glu Leu Phe Lys Gln 
145                 150                 155                 160 


Ala Val Tyr Lys Gln Thr Met Lys Leu Phe Ala Glu Leu Glu Ile Lys 
                165                 170                 175     


Arg Lys Glu Arg Glu Ala Lys Glu Met His Glu Arg Lys Arg Gln Arg 
            180                 185                 190         


Glu Glu Glu Ile Glu Ala Gln Glu Lys Ala Lys Arg Glu Arg Glu Trp 
        195                 200                 205             


Gln Lys Asn Phe Glu Glu Ser Arg Asp Gly Arg Val Asp Ser Trp Arg 
    210                 215                 220                 


Asn Phe Gln Ala Asn Thr Lys Gly Lys Lys Glu Lys Lys Asn Arg Thr 
225                 230                 235                 240 


Phe Leu Arg Pro Pro Lys Val Lys Met Glu Gln Arg Glu 
                245                 250             


<210>  8452
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC8__Homo_sapiens__AAH33159

<400>  8452
auggcggcuu caggagagag cgggacuuca ggcggcggag gcagcaccga ggaagcauuu       60

augaccuucu acagugaggu gaaacaaaua gagaagagag acucgguucu aacuucgaaa      120

aaucagauug aaagacugac ccguccuggu uccucuuacu ucaauuugaa cccauuugag      180

guucuucaga uagauccuga aguuacagau gaagaaauaa aaaagagguu ucggcaguua      240

uccaucuugg ugcauccuga caaaaaucaa gaugaugcug acagagcaca aaaggcuuuu      300

gaagcugugg acaaagcuua caaguugcua cuggaucagg agcaaaagaa gagggcccug      360

gauguaauuc aggcaggaaa agaauacgug gaacacacug ugaaagagcg aaaaaaacaa      420

uuaaagaagg aaggaaaacc uacaauugua gaggaggaug auccugagcu guucaaacaa      480

gcuguauaua aacagacaau gaaacucuuu gcagagcugg aaauuaaaag gaaagagaga      540

gaagccaaag aaaugcauga aaggaaacga caaagggaag aagagauuga agcucaagaa      600

aaagccaaac gggaaagaga guggcagaaa aacuuugagg aaagucgaga uggucgugug      660

gacagcuggc gaaacuucca agccaauacg aaggggaaga aagagaagaa aaaucggacc      720

uuccugagac caccgaaagu aaaaauggag caacgugagu ga                         762


<210>  8453
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC8__Homo_sapiens__AAH33159

<400>  8453
auggccgcca gcggcgaguc cgggaccagc ggcgggggcg gguccaccga ggaggcguuc       60

augacguucu acagcgaggu gaagcagauc gagaagcgcg acuccguccu gaccagcaag      120

aaccagaucg agcggcucac ccgccccggc uccagcuacu ucaaccugaa ccccuucgag      180

gugcugcaga ucgaccccga ggugaccgac gaggagauca agaagcgguu ccgccagcuc      240

uccauccugg uccaccccga caagaaccag gacgacgccg accgggccca gaaggccuuc      300

gaggccgugg acaaggcgua caagcugcuc cuggaccagg agcagaagaa gcgcgcccug      360

gacgugaucc aggccggcaa ggaguacguc gagcacacgg ugaaggagcg gaagaagcag      420

cucaagaagg aggggaagcc caccaucgug gaggaggacg acccggagcu guucaagcag      480

gccgucuaca agcagaccau gaagcuguuc gcggagcucg agaucaagcg caaggagcgg      540

gaggccaagg agaugcacga gcgcaagcgg cagcgcgagg aggagaucga ggcccaggag      600

aaggccaagc gggagcgcga guggcagaag aacuucgagg agagccggga cggccgcgug      660

gacuccuggc ggaacuucca ggccaacacc aaggggaaga aggagaagaa gaaccgcacg      720

uuccugcggc cgcccaaggu gaagauggag cagcgcgagu ga                         762


<210>  8454
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC8__Homo_sapiens__AAH33159

<400>  8454
auggccgccu ccggcgaguc cggcaccucc ggcggcggcg gcuccaccga ggaggccuuc       60

augaccuucu acuccgaggu caagcagauc gagaagcgcg acuccguccu caccuccaag      120

aaccagaucg agcgccucac ccgccccggc uccuccuacu ucaaccucaa ccccuucgag      180

guccuccaga ucgaccccga ggucaccgac gaggagauca agaagcgcuu ccgccagcuc      240

uccauccucg uccaccccga caagaaccag gacgacgccg accgcgccca gaaggccuuc      300

gaggccgucg acaaggccua caagcuccuc cucgaccagg agcagaagaa gcgcgcccuc      360

gacgucaucc aggccggcaa ggaguacguc gagcacaccg ucaaggagcg caagaagcag      420

cucaagaagg agggcaagcc caccaucguc gaggaggacg accccgagcu cuucaagcag      480

gccgucuaca agcagaccau gaagcucuuc gccgagcucg agaucaagcg caaggagcgc      540

gaggccaagg agaugcacga gcgcaagcgc cagcgcgagg aggagaucga ggcccaggag      600

aaggccaagc gcgagcgcga guggcagaag aacuucgagg agucccgcga cggccgcguc      660

gacuccuggc gcaacuucca ggccaacacc aagggcaaga aggagaagaa gaaccgcacc      720

uuccuccgcc cccccaaggu caagauggag cagcgcgagu ga                         762


<210>  8455
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC8__Homo_sapiens__AAH33159

<400>  8455
auggccgcua gcggcgaguc cgggaccucu ggagguggcg ggucaacaga agaggcauuc       60

augacuuuuu acagugaagu gaagcagauc gagaaaagag acagcguccu gacguccaag      120

aaccaaauug aaaggcucac ccggcccgga ucuucguauu ucaaucuuaa cccuuuugag      180

guucugcaga uagauccaga ggugacagac gaagagauca aaaagcgcuu ccgacaguug      240

ucaauuuuag uacacccgga uaaaaaucag gacgaugccg accgugcgca aaaggcuuuu      300

gaagccgugg auaaggcaua caaacugcua cucgaccagg agcagaagaa aagagcccug      360

gaugucaucc aggcuggcaa ggaguaugug gaacauacug uuaaagagag gaagaagcaa      420

cuuaaaaagg aagguaaacc caccauugug gaggaagacg auccugagcu guucaagcag      480

gcagucuaca aacagacaau gaaguuguuu gccgagcucg aaaucaaacg gaaggagcgc      540

gaagcuaagg agaugcacga aagaaaaagg cagcgggagg aggaaauaga ggcccaagaa      600

aaggcgaaac gcgagcgaga auggcagaag aacuucgagg agagcagaga cgggagggug      660

gauaguuggc ggaauuuuca ggcaaacacc aaaggaaaga aggagaaaaa gaaucguacu      720

uuccugcgcc cacccaaagu aaagauggaa caaagagaau ga                         762


<210>  8456
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC8__Homo_sapiens__AAH33159

<400>  8456
auggccgcca gcggcgagag cggcaccagc ggcggcggcg gcagcaccga ggaggccuuc       60

augaccuucu acagcgaggu gaagcagauc gagaagagag acagcgugcu gaccagcaag      120

aaccagaucg agagacugac cagacccggc agcagcuacu ucaaccugaa ccccuucgag      180

gugcugcaga ucgaccccga ggugaccgac gaggagauca agaagagauu cagacagcug      240

agcauccugg ugcaccccga caagaaccag gacgacgccg acagagccca gaaggccuuc      300

gaggccgugg acaaggccua caagcugcug cuggaccagg agcagaagaa gagagcccug      360

gacgugaucc aggccggcaa ggaguacgug gagcacaccg ugaaggagag aaagaagcag      420

cugaagaagg agggcaagcc caccaucgug gaggaggacg accccgagcu guucaagcag      480

gccguguaca agcagaccau gaagcuguuc gccgagcugg agaucaagag aaaggagaga      540

gaggccaagg agaugcacga gagaaagaga cagagagagg aggagaucga ggcccaggag      600

aaggccaaga gagagagaga guggcagaag aacuucgagg agagcagaga cggcagagug      660

gacagcugga gaaacuucca ggccaacacc aagggcaaga aggagaagaa gaacagaacc      720

uuccugagac cccccaaggu gaagauggag cagagagagu ga                         762


<210>  8457
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC8__Homo_sapiens__AAH33159

<400>  8457
auggccgcua gcggcgaguc cgggaccucu ggaggcgggg gaagcacaga agaggccuuc       60

augacguuuu acuccgaagu gaagcagauc gagaaaagag acucuguccu gaccagcaag      120

aaccaaauug aacggcucac acgccccggc uccucuuauu ucaaucugaa cccuuuugag      180

guucuucaga ucgauccgga ggugaccgac gaagagauua aaaagagauu ccggcagcug      240

agcauccucg ugcaccccga uaaaaaucag gacgaugcgg accgcgcuca aaaggccuuu      300

gaagccgucg auaaggcuua caaacugcuu cuggaccagg agcagaagaa aagagcccuc      360

gaugugauuc aggcugggaa ggaguauguu gaacauacag ugaaagagcg gaagaagcaa      420

cugaaaaagg aaggaaaacc uaccaucguc gaggaagacg aucccgagcu guucaagcag      480

gccguguaca aacagacaau gaagcucuuu gcggagcugg aaaucaaacg caaggagaga      540

gaagccaagg agaugcacga acggaaacgc cagagagagg aggaaauuga ggcucaagaa      600

aaggccaaac gggagcgcga auggcagaag aacuucgagg aguccagaga cggccggguu      660

gauagcuggc gcaauuuuca ggcuaacacc aaaggcaaga aggagaaaaa gaauagaacg      720

uuccuucggc cucccaaagu gaagauggaa caaagagaau ga                         762


<210>  8458
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DNJC9__Homo_sapiens__Q8WXX5

<400>  8458

Met Gly Leu Leu Asp Leu Cys Glu Glu Val Phe Gly Thr Ala Asp Leu 
1               5                   10                  15      


Tyr Arg Val Leu Gly Val Arg Arg Glu Ala Ser Asp Gly Glu Val Arg 
            20                  25                  30          


Arg Gly Tyr His Lys Val Ser Leu Gln Val His Pro Asp Arg Val Gly 
        35                  40                  45              


Glu Gly Asp Lys Glu Asp Ala Thr Arg Arg Phe Gln Ile Leu Gly Lys 
    50                  55                  60                  


Val Tyr Ser Val Leu Ser Asp Arg Glu Gln Arg Ala Val Tyr Asp Glu 
65                  70                  75                  80  


Gln Gly Thr Val Asp Glu Asp Ser Pro Val Leu Thr Gln Asp Arg Asp 
                85                  90                  95      


Trp Glu Ala Tyr Trp Arg Leu Leu Phe Lys Lys Ile Ser Leu Glu Asp 
            100                 105                 110         


Ile Gln Ala Phe Glu Lys Thr Tyr Lys Gly Ser Glu Glu Glu Leu Ala 
        115                 120                 125             


Asp Ile Lys Gln Ala Tyr Leu Asp Phe Lys Gly Asp Met Asp Gln Ile 
    130                 135                 140                 


Met Glu Ser Val Leu Cys Val Gln Tyr Thr Glu Glu Pro Arg Ile Arg 
145                 150                 155                 160 


Asn Ile Ile Gln Gln Ala Ile Asp Ala Gly Glu Val Pro Ser Tyr Asn 
                165                 170                 175     


Ala Phe Val Lys Glu Ser Lys Gln Lys Met Asn Ala Arg Lys Arg Arg 
            180                 185                 190         


Ala Gln Glu Glu Ala Lys Glu Ala Glu Met Ser Arg Lys Glu Leu Gly 
        195                 200                 205             


Leu Asp Glu Gly Val Asp Ser Leu Lys Ala Ala Ile Gln Ser Arg Gln 
    210                 215                 220                 


Lys Asp Arg Gln Lys Glu Met Asp Asn Phe Leu Ala Gln Met Glu Ala 
225                 230                 235                 240 


Lys Tyr Cys Lys Ser Ser Lys Gly Gly Gly Lys Lys Ser Ala Leu Lys 
                245                 250                 255     


Lys Glu Lys Lys 
            260 


<210>  8459
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  DNJC9__Homo_sapiens__AAI36508

<400>  8459
auggggcugc uggaccuuug cgaggaagug uucggcaccg ccgaccuuua ccgggugcug       60

ggcgugcgac gcgaggccuc cgacggcgag guccgacgag gcuaccacaa ggugucccug      120

cagguacacc cggaccgggu gggugagggc gacaaggagg acgccacccg ccgcuuccag      180

auccugggaa aagucuauuc cguucucagu gacagagaac agagagcagu guacgaugag      240

cagggaacag uggacgagga cucuccugug cucacccaag accgagacug ggaggcguau      300

uggcggcuac ucuuuaaaaa gauaucuuua gaggacauuc aagcuuuuga aaagacauac      360

aaagguucgg aagaagagcu ggcugauauu aagcaggccu aucuggacuu caagggugac      420

auggaucaga ucauggaguc ugugcuuugc gugcaguaca cagaggaacc caggauaagg      480

aauaucauuc agcaagcuau ugacgccgga gaggucccau ccuauaaugc cuuugucaaa      540

gaaucgaaac aaaagaugaa ugcaaggaaa aggagggcuc aggaagaggc caaagaagca      600

gaaaugagca gaaaggaguu ggggcuugau gaaggcgugg auagccugaa ggcagccauu      660

cagagcagac aaaaggaucg gcaaaaggaa auggacaauu uucuggcuca gauggaagca      720

aaguacugca aaucuuccaa aggaggaggg aaaaaaucug cucucaagaa agaaaagaaa      780

uaa                                                                    783


<210>  8460
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       DNJC9__Homo_sapiens__AAI36508

<400>  8460
augggccugc ucgaccugug cgaggaggug uucgggaccg ccgaccugua ccgcguccuc       60

ggcgugcggc gcgaggccag cgacggggag gugcggcgcg gcuaccacaa ggucucccuc      120

caggugcacc ccgaccgggu gggggagggc gacaaggagg acgcgacccg ccgguuccag      180

auccugggca aggucuacag cgugcucucc gaccgcgagc agcgggccgu guacgacgag      240

caggggacgg ucgacgagga cagcccggug cugacccagg accgcgacug ggaggccuac      300

uggcggcugc uguucaagaa gaucucccug gaggacaucc aggccuucga gaagaccuac      360

aagggcagcg aggaggagcu ggccgacauc aagcaggcgu accucgacuu caagggggac      420

auggaccaga ucauggaguc cgugcugugc guccaguaca ccgaggagcc ccgcauccgg      480

aacaucaucc agcaggccau cgacgccggc gaggugccca gcuacaacgc cuucgugaag      540

gaguccaagc agaagaugaa cgcgcgcaag cggcgcgccc aggaggaggc caaggaggcc      600

gagaugagcc ggaaggagcu ggggcucgac gagggcgucg acucccugaa ggccgcgauc      660

cagagccgcc agaaggaccg gcagaaggag auggacaacu uccuggccca gauggaggcc      720

aaguacugca aguccagcaa gggcgggggc aagaaguccg cccucaagaa ggagaagaag      780

uga                                                                    783


<210>  8461
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       DNJC9__Homo_sapiens__AAI36508

<400>  8461
augggccucc ucgaccucug cgaggagguc uucggcaccg ccgaccucua ccgcguccuc       60

ggcguccgcc gcgaggccuc cgacggcgag guccgccgcg gcuaccacaa ggucucccuc      120

cagguccacc ccgaccgcgu cggcgagggc gacaaggagg acgccacccg ccgcuuccag      180

auccucggca aggucuacuc cguccucucc gaccgcgagc agcgcgccgu cuacgacgag      240

cagggcaccg ucgacgagga cucccccguc cucacccagg accgcgacug ggaggccuac      300

uggcgccucc ucuucaagaa gaucucccuc gaggacaucc aggccuucga gaagaccuac      360

aagggcuccg aggaggagcu cgccgacauc aagcaggccu accucgacuu caagggcgac      420

auggaccaga ucauggaguc cguccucugc guccaguaca ccgaggagcc ccgcauccgc      480

aacaucaucc agcaggccau cgacgccggc gagguccccu ccuacaacgc cuucgucaag      540

gaguccaagc agaagaugaa cgcccgcaag cgccgcgccc aggaggaggc caaggaggcc      600

gagauguccc gcaaggagcu cggccucgac gagggcgucg acucccucaa ggccgccauc      660

cagucccgcc agaaggaccg ccagaaggag auggacaacu uccucgccca gauggaggcc      720

aaguacugca aguccuccaa gggcggcggc aagaaguccg cccucaagaa ggagaagaag      780

uga                                                                    783


<210>  8462
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       DNJC9__Homo_sapiens__AAI36508

<400>  8462
augggccugc ucgaccuuug cgaggaagug uucgggaccg ccgaucugua cagagucuug       60

ggaguuaggc gggaggcuag cgacggugaa gugcgccgag gcuaucacaa gguauccuua      120

caggugcauc ccgaucgugu cggggaggga gacaaagaag augcaacaag aagguuucaa      180

auccugggca agguguacuc uguucuauca gaccgggagc agcgcgccgu guaugaugag      240

caggguacug ucgacgaaga uaguccugug cucacgcagg acagagauug ggaggcguac      300

uggaggcugc uuuucaaaaa gauuagccug gaagacauac aggcuuuuga gaaaaccuau      360

aagggguccg aggaagaguu ggccgauauc aagcaagcau accucgacuu caaaggagac      420

auggaucaga uuauggaauc uguacugugu guucaguaua cagaggaacc acggauccgc      480

aacauuaucc aacaggccau agacgcuggc gaggugccgu cguacaaugc auuugucaag      540

gagucaaaac agaagaugaa cgcccgaaaa agaagggcuc aggaagaggc caaggaagcg      600

gagaugagcc ggaaggaacu gggccucgau gagggggugg acaguuuaaa agcagccauc      660

caaucccguc agaaggaucg ccagaaagag auggacaauu uccuggcuca aauggaagcc      720

aaguacugca aaucuagcaa gggagguggc aaaaaguccg cacuuaagaa agagaagaaa      780

uga                                                                    783


<210>  8463
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       DNJC9__Homo_sapiens__AAI36508

<400>  8463
augggccugc uggaccugug cgaggaggug uucggcaccg ccgaccugua cagagugcug       60

ggcgugagaa gagaggccag cgacggcgag gugagaagag gcuaccacaa ggugagccug      120

caggugcacc ccgacagagu gggcgagggc gacaaggagg acgccaccag aagauuccag      180

auccugggca agguguacag cgugcugagc gacagagagc agagagccgu guacgacgag      240

cagggcaccg uggacgagga cagccccgug cugacccagg acagagacug ggaggccuac      300

uggagacugc uguucaagaa gaucagccug gaggacaucc aggccuucga gaagaccuac      360

aagggcagcg aggaggagcu ggccgacauc aagcaggccu accuggacuu caagggcgac      420

auggaccaga ucauggagag cgugcugugc gugcaguaca ccgaggagcc cagaaucaga      480

aacaucaucc agcaggccau cgacgccggc gaggugccca gcuacaacgc cuucgugaag      540

gagagcaagc agaagaugaa cgccagaaag agaagagccc aggaggaggc caaggaggcc      600

gagaugagca gaaaggagcu gggccuggac gagggcgugg acagccugaa ggccgccauc      660

cagagcagac agaaggacag acagaaggag auggacaacu uccuggccca gauggaggcc      720

aaguacugca agagcagcaa gggcggcggc aagaagagcg cccugaagaa ggagaagaag      780

uga                                                                    783


<210>  8464
<211>  783
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       DNJC9__Homo_sapiens__AAI36508

<400>  8464
augggccugc ucgaccugug cgaggaagug uucgggaccg ccgaucuuua cagaguccug       60

ggaguucggc gcgaggcuag cgacggcgaa gugagacggg gguaucacaa ggugucccuc      120

cagguccauc ccgaucgcgu gggagagggc gacaaagaag augccacaag acgguuucaa      180

auccugggga agguuuacuc ugugcuuagc gaccgcgagc agagagcggu cuaugaugag      240

cagggaacgg uggacgaaga uuccccuguu cugacccagg accgggauug ggaggcuuac      300

uggcgccucc uguucaaaaa gauuucucug gaagacaucc aagccuuuga gaaaacauau      360

aagggcagcg aggaggaacu cgccgauauu aagcaggcuu accuggacuu caaaggcgac      420

auggaucaga ucauggaauc cgugcuuugu guccaguaua ccgaggaacc gcggauuaga      480

aacaucaucc aacaggccau ugacgcuggg gaggugcccu cuuacaaugc cuuugugaag      540

gagagcaaac agaagaugaa cgcgcgcaaa agacgggccc aggaagaggc uaaggaagcc      600

gagauguccc gcaaggaacu gggacucgau gagggcgucg acagccugaa agcugccauc      660

caaucuagac agaaggaucg gcagaaagag auggacaauu uccuugcgca aauggaagcc      720

aaguacugca aauccagcaa agggggaggc aagaagucug cucugaagaa agagaagaaa      780

uga                                                                    783


<210>  8465
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Elk-1__Homo_sapiens__P19419

<400>  8465

Met Asp Pro Ser Val Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Arg 
1               5                   10                  15      


Glu Gln Gly Asn Gly His Ile Ile Ser Trp Thr Ser Arg Asp Gly Gly 
            20                  25                  30          


Glu Phe Lys Leu Val Asp Ala Glu Glu Val Ala Arg Leu Trp Gly Leu 
        35                  40                  45              


Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg Lys Val Ser Gly Gln Lys 
65                  70                  75                  80  


Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu Val Ala Gly Cys Ser Thr 
                85                  90                  95      


Glu Asp Cys Pro Pro Gln Pro Glu Val Ser Val Thr Ser Thr Met Pro 
            100                 105                 110         


Asn Val Ala Pro Ala Ala Ile His Ala Ala Pro Gly Asp Thr Val Ser 
        115                 120                 125             


Gly Lys Pro Gly Thr Pro Lys Gly Ala Gly Met Ala Gly Pro Gly Gly 
    130                 135                 140                 


Leu Ala Arg Ser Ser Arg Asn Glu Tyr Met Arg Ser Gly Leu Tyr Ser 
145                 150                 155                 160 


Thr Phe Thr Ile Gln Ser Leu Gln Pro Gln Pro Pro Pro His Pro Arg 
                165                 170                 175     


Pro Ala Val Val Leu Pro Ser Ala Ala Pro Ala Gly Ala Ala Ala Pro 
            180                 185                 190         


Pro Ser Gly Ser Arg Ser Thr Ser Pro Ser Pro Leu Glu Ala Cys Leu 
        195                 200                 205             


Glu Ala Glu Glu Ala Gly Leu Pro Leu Gln Val Ile Leu Thr Pro Pro 
    210                 215                 220                 


Glu Ala Pro Asn Leu Lys Ser Glu Glu Leu Asn Val Glu Pro Gly Leu 
225                 230                 235                 240 


Gly Arg Ala Leu Pro Pro Glu Val Lys Val Glu Gly Pro Lys Glu Glu 
                245                 250                 255     


Leu Glu Val Ala Gly Glu Arg Gly Phe Val Pro Glu Thr Thr Lys Ala 
            260                 265                 270         


Glu Pro Glu Val Pro Pro Gln Glu Gly Val Pro Ala Arg Leu Pro Ala 
        275                 280                 285             


Val Val Met Asp Thr Ala Gly Gln Ala Gly Gly His Ala Ala Ser Ser 
    290                 295                 300                 


Pro Glu Ile Ser Gln Pro Gln Lys Gly Arg Lys Pro Arg Asp Leu Glu 
305                 310                 315                 320 


Leu Pro Leu Ser Pro Ser Leu Leu Gly Gly Pro Gly Pro Glu Arg Thr 
                325                 330                 335     


Pro Gly Ser Gly Ser Gly Ser Gly Leu Gln Ala Pro Gly Pro Ala Leu 
            340                 345                 350         


Thr Pro Ser Leu Leu Pro Thr His Thr Leu Thr Pro Val Leu Leu Thr 
        355                 360                 365             


Pro Ser Ser Leu Pro Pro Ser Ile His Phe Trp Ser Thr Leu Ser Pro 
    370                 375                 380                 


Ile Ala Pro Arg Ser Pro Ala Lys Leu Ser Phe Gln Phe Pro Ser Ser 
385                 390                 395                 400 


Gly Ser Ala Gln Val His Ile Pro Ser Ile Ser Val Asp Gly Leu Ser 
                405                 410                 415     


Thr Pro Val Val Leu Ser Pro Gly Pro Gln Lys Pro 
            420                 425             


<210>  8466
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Elk-1__Homo_sapiens__AAH56150

<400>  8466
auggacccau cugugacgcu guggcaguuu cugcugcagc ugcugagaga gcaaggcaau       60

ggccacauca ucuccuggac uucacgggau gguggugaau ucaagcuggu ggaugcagag      120

gagguggccc ggcugugggg gcuacgcaag aacaagacca acaugaauua cgacaagcuc      180

agccgggccu ugcgguacua cuaugacaag aacaucaucc gcaaggugag cggccagaag      240

uucgucuaca aguuuguguc cuacccugag gucgcagggu gcuccacuga ggacugcccg      300

ccccagccag aggugucugu uaccuccacc augccaaaug uggccccugc ugcuauacau      360

gccgccccag gggacacugu cucuggaaag ccaggcacac ccaagggugc aggaauggca      420

ggcccaggcg guuuggcacg cagcagccgg aacgaguaca ugcgcucggg ccucuauucc      480

accuucacca uccagucucu gcagccgcag ccacccccuc auccucggcc ugcuguggug      540

cuccccagug cagcuccugc aggggcagca gcgccccccu cggggagcag gagcaccagu      600

ccaagccccu uggaggccug ucuggaggcu gaagaggccg gcuugccucu gcaggucauc      660

cugaccccgc ccgaggcccc aaaccugaaa ucggaagagc uuaaugugga gccggguuug      720

ggccgggcuu ugcccccaga agugaaagua gaagggccca aggaagaguu ggaaguugcg      780

ggggagagag gguuugugcc agaaaccacc aaggccgagc cagaaguccc uccacaggag      840

ggcgugccag cccggcugcc cgcgguuguu auggacaccg cagggcaggc gggcggccau      900

gcggcuucca gcccugagau cucccagccg cagaagggcc ggaagccccg ggaccuagag      960

cuuccacuca gcccgagccu gcuagguggg ccgggacccg aacggacccc aggaucggga     1020

aguggcuccg gccuccaggc uccggggccg gcgcugaccc caucccugcu uccuacgcau     1080

acauugaccc cggugcugcu gacacccagc ucgcugccuc cuagcauuca cuucuggagc     1140

acccugaguc ccauugcgcc ccguagcccg gccaagcucu ccuuccaguu uccauccagu     1200

ggcagcgccc aggugcacau cccuucuauc agcguggaug gccucucgac ccccguggug     1260

cucuccccag ggccccagaa gccauga                                         1287


<210>  8467
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Elk-1__Homo_sapiens__AAH56150

<400>  8467
auggacccca gcgugacccu guggcaguuc cuccugcagc ugcuccgcga gcagggcaac       60

gggcacauca ucuccuggac cagccgggac ggcggggagu ucaagcuggu cgacgccgag      120

gagguggccc gccugugggg ccuccggaag aacaagacga acaugaacua cgacaagcug      180

ucccgcgcgc ugcgguacua cuacgacaag aacaucaucc gcaaggugag cgggcagaag      240

uucgucuaca aguucguguc cuacccggag guggccggcu gcagcaccga ggacugcccg      300

ccccagcccg aggucuccgu gaccagcacc augcccaacg uggcccccgc cgccauccac      360

gcggcccccg gcgacacggu cuccgggaag cccggcaccc cgaagggggc cggcauggcc      420

gggcccggcg gccucgcgcg gagcucccgc aacgaguaca ugcggagcgg gcuguacucc      480

accuucacca uccagagccu gcagccccag cccccgcccc acccccgccc cgccguggug      540

cucccguccg ccgcccccgc cggcgcggcc gccccgccca gcgggucccg gagcacgucc      600

cccagccccc uggaggccug ccuggaggcc gaggaggcgg gccucccccu gcaggucauc      660

cugacgcccc cggaggcccc caaccucaag agcgaggagc ugaacgugga gcccggccug      720

gggcgcgccc ugcccccgga ggugaagguc gagggcccca aggaggagcu ggagguggcc      780

ggggagcggg gcuucgugcc cgagaccacc aaggccgagc cggagguccc gccccaggag      840

ggggugcccg cgcgccugcc cgccgugguc auggacaccg ccggccaggc cggcgggcac      900

gccgcgucca gccccgagau cucccagccc cagaagggcc ggaagccccg cgaccucgag      960

cugccgcuga gccccucccu ccucgggggc cccgggcccg agcggacccc gggcagcggc     1020

uccgggagcg gccugcaggc ccccgggccc gcccucaccc ccucccugcu gccgacccac     1080

acgcucaccc ccgugcugcu gacccccagc ucccugcccc cgagcaucca cuucuggucc     1140

acccucagcc ccaucgcgcc ccgcuccccc gccaagcuga gcuuccaguu cccguccagc     1200

ggcuccgccc aggugcacau ccccagcauc agcgucgacg ggcucuccac gcccgugguc     1260

cugagcccgg gcccccagaa gcccuga                                         1287


<210>  8468
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Elk-1__Homo_sapiens__AAH56150

<400>  8468
auggaccccu ccgucacccu cuggcaguuc cuccuccagc uccuccgcga gcagggcaac       60

ggccacauca ucuccuggac cucccgcgac ggcggcgagu ucaagcucgu cgacgccgag      120

gaggucgccc gccucugggg ccuccgcaag aacaagacca acaugaacua cgacaagcuc      180

ucccgcgccc uccgcuacua cuacgacaag aacaucaucc gcaaggucuc cggccagaag      240

uucgucuaca aguucgucuc cuaccccgag gucgccggcu gcuccaccga ggacugcccc      300

ccccagcccg aggucuccgu caccuccacc augcccaacg ucgcccccgc cgccauccac      360

gccgcccccg gcgacaccgu cuccggcaag cccggcaccc ccaagggcgc cggcauggcc      420

ggccccggcg gccucgcccg cuccucccgc aacgaguaca ugcgcuccgg ccucuacucc      480

accuucacca uccagucccu ccagccccag cccccccccc acccccgccc cgccgucguc      540

cuccccuccg ccgcccccgc cggcgccgcc gccccccccu ccggcucccg cuccaccucc      600

cccucccccc ucgaggccug ccucgaggcc gaggaggccg gccucccccu ccaggucauc      660

cucacccccc ccgaggcccc caaccucaag uccgaggagc ucaacgucga gcccggccuc      720

ggccgcgccc ucccccccga ggucaagguc gagggcccca aggaggagcu cgaggucgcc      780

ggcgagcgcg gcuucguccc cgagaccacc aaggccgagc ccgagguccc cccccaggag      840

ggcguccccg cccgccuccc cgccgucguc auggacaccg ccggccaggc cggcggccac      900

gccgccuccu cccccgagau cucccagccc cagaagggcc gcaagccccg cgaccucgag      960

cucccccucu cccccucccu ccucggcggc cccggccccg agcgcacccc cggcuccggc     1020

uccggcuccg gccuccaggc ccccggcccc gcccucaccc ccucccuccu ccccacccac     1080

acccucaccc ccguccuccu cacccccucc ucccuccccc ccuccaucca cuucuggucc     1140

acccucuccc ccaucgcccc ccgcuccccc gccaagcucu ccuuccaguu ccccuccucc     1200

ggcuccgccc agguccacau ccccuccauc uccgucgacg gccucuccac ccccgucguc     1260

cucucccccg gcccccagaa gcccuga                                         1287


<210>  8469
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Elk-1__Homo_sapiens__AAH56150

<400>  8469
auggacccca gcgugacccu guggcaguuc cuccuucaac uguugagaga gcagggcaac       60

gggcacauca uuuccuggac aucuagggau ggaggugaau uuaaguuagu cgacgccgag      120

gaaguugcuc ggcugugggg ccuacgcaaa aauaagacua acaugaauua cgauaaacuc      180

ucacgagcac ugcguuauua cuaugacaag aacauaauca gaaaagugag ugggcagaag      240

uucguauaca aguuugugag cuauccugag gucgccggau gcuccacgga agauugucca      300

ccgcagcccg aggugucugu uaccucgaca augccuaaug uggcgccagc ugccauucau      360

gcagcccccg gcgacacugu cucagguaaa ccugggaccc caaagggagc uggcauggca      420

ggccccgggg gacuugccag gagcagucgg aacgaguaca ugcgcuccgg ucuguauucu      480

acauucacca uccagagcuu gcaaccucag ccaccgcccc acccuagacc agcuguggua      540

cuccccuccg ccgcgccugc aggcgccgcu gccccacccu cagggaguag gagcacuucu      600

ccguccccuc uggaagcaug ccuggaggcu gaagaggccg gacuccccuu acagguuauu      660

cugacaccac cugaggcgcc caaucuuaaa ucagaagagu ugaacgugga accaggccug      720

ggucgggccc uacccccuga ggucaaggug gaagggccaa aagaggagcu cgaaguggca      780

ggagagcgcg gcuuuguccc ggaaaccacg aaggcugagc ccgaaguucc uccacaagag      840

ggcgugcccg cccgacugcc ugcuguagug auggauacug ccgggcaggc aggaggucau      900

gccgcuagca guccagagau cucucagccc cagaagggca gaaaaccgag ggaccuugaa      960

cugccuuugu ccccaagccu cuuaggggga cccggcccug agcggacccc cgguucgggg     1020

ucuggcuccg gacugcaagc gccaggcccu gcacugacac ccucacuccu uccaacucac     1080

acccugacac cggucuugcu aaccccuagu agccugcccc cauccauaca uuucuggucu     1140

acgcucagcc ccaucgcccc ucguucacca gcuaagcuga guuuucaguu ccccuccagc     1200

gggucugccc aggugcacau uccuucaauc aguguugaug gacuuagcac uccggugguc     1260

cuguccccag guccccaaaa accuuga                                         1287


<210>  8470
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Elk-1__Homo_sapiens__AAH56150

<400>  8470
auggacccca gcgugacccu guggcaguuc cugcugcagc ugcugagaga gcagggcaac       60

ggccacauca ucagcuggac cagcagagac ggcggcgagu ucaagcuggu ggacgccgag      120

gagguggcca gacugugggg ccugagaaag aacaagacca acaugaacua cgacaagcug      180

agcagagccc ugagauacua cuacgacaag aacaucauca gaaaggugag cggccagaag      240

uucguguaca aguucgugag cuaccccgag guggccggcu gcagcaccga ggacugcccc      300

ccccagcccg aggugagcgu gaccagcacc augcccaacg uggcccccgc cgccauccac      360

gccgcccccg gcgacaccgu gagcggcaag cccggcaccc ccaagggcgc cggcauggcc      420

ggccccggcg gccuggccag aagcagcaga aacgaguaca ugagaagcgg ccuguacagc      480

accuucacca uccagagccu gcagccccag cccccccccc accccagacc cgccguggug      540

cugcccagcg ccgcccccgc cggcgccgcc gcccccccca gcggcagcag aagcaccagc      600

cccagccccc uggaggccug ccuggaggcc gaggaggccg gccugccccu gcaggugauc      660

cugacccccc ccgaggcccc caaccugaag agcgaggagc ugaacgugga gcccggccug      720

ggcagagccc ugccccccga ggugaaggug gagggcccca aggaggagcu ggagguggcc      780

ggcgagagag gcuucgugcc cgagaccacc aaggccgagc ccgaggugcc cccccaggag      840

ggcgugcccg ccagacugcc cgccguggug auggacaccg ccggccaggc cggcggccac      900

gccgccagca gccccgagau cagccagccc cagaagggca gaaagcccag agaccuggag      960

cugccccuga gccccagccu gcugggcggc cccggccccg agagaacccc cggcagcggc     1020

agcggcagcg gccugcaggc ccccggcccc gcccugaccc ccagccugcu gcccacccac     1080

acccugaccc ccgugcugcu gacccccagc agccugcccc ccagcaucca cuucuggagc     1140

acccugagcc ccaucgcccc cagaagcccc gccaagcuga gcuuccaguu ccccagcagc     1200

ggcagcgccc aggugcacau ccccagcauc agcguggacg gccugagcac ccccguggug     1260

cugagccccg gcccccagaa gcccuga                                         1287


<210>  8471
<211>  1287
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Elk-1__Homo_sapiens__AAH56150

<400>  8471
auggacccca gcgugacccu guggcaguuc cuccugcaac uucugagaga gcagggcaac       60

gggcacauca uuuccuggac aucucgggau ggaggcgaau uuaagcucgu cgacgccgag      120

gaaguugcuc gccugugggg gcuucggaaa aauaagacga acaugaauua cgauaaacug      180

agcagagccc uccgcuauua cuaugacaag aacaucauua gaaaaguguc cggacagaag      240

uucguguaca aguuugucuc uuauccugag guggcgggcu gcagcaccga agauuguccg      300

ccccagccug agguuuccgu gacaucuacc augcccaaug ucgcuccugc cgccauccau      360

gcugcccccg gggacacagu gagcggaaaa ccuggcaccc cgaagggcgc ugggauggcc      420

ggacccggcg ggcuggcgcg guccagccgc aacgaguaca ugagaucugg acuguauucc      480

acauucacca uucaaagccu ccagccucag cccccucccc acccgcggcc ugccguugug      540

cugcccucug cugccccugc uggcgccgcg gccccucccu ccgggagccg cucuacgucc      600

cccagcccgc uugaggcuug ccuggaggcc gaagaggcug gacucccccu gcaggucauc      660

cuuaccccuc ccgaggcccc uaaucugaaa uccgaagaac ucaacgugga acccggccug      720

ggcagagccc ugccgccuga ggugaagguc gaagggccca aagaggagcu cgaaguugcu      780

ggagagcggg gcuuugugcc ugaaacaacc aaggcggagc ccgaagugcc uccccaagag      840

ggggucccgg cccgccugcc ugcugugguu auggauacag ccggacaggc cggcgggcau      900

gcugccucua gccccgagau cucccagccc cagaagggaa gaaaaccucg ggaccuugaa      960

cugccgcuca gccccucucu gcuuggcggc ccugggcccg agcgcacccc uggauccggc     1020

agcgggucug gacugcaagc gcccggcccu gcucucacgc ccagccugcu gccgacacac     1080

acccucacac cugugcugcu uacccccucc ucucugccuc ccagcauuca uuucuggucc     1140

acccucagcc cgaucgcccc uagaucuccc gccaagcugu ccuuucaguu cccuagcucu     1200

ggguccgcuc agguccacau ucccagcauc uccguggaug gccuuucuac acccguugug     1260

cugagcccug gaccgcaaaa acccuga                                         1287


<210>  8472
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Elk-1__Homo_sapiens__Q8N9S0

<400>  8472

Met Asp Thr Ala Gly Gln Ala Gly Gly His Ala Ala Ser Ser Pro Glu 
1               5                   10                  15      


Ile Ser Gln Pro Gln Lys Gly Arg Lys Pro Arg Asp Leu Glu Leu Pro 
            20                  25                  30          


Leu Ser Pro Ser Leu Leu Gly Gly Pro Gly Pro Glu Arg Thr Pro Ser 
        35                  40                  45              


Leu Leu Pro Thr His Thr Leu Thr Pro Val Leu Leu Thr Pro Ser Ser 
    50                  55                  60                  


Leu Pro Pro Ser Ile His Phe Trp Ser Thr Leu Ser Pro Ile Ala Pro 
65                  70                  75                  80  


Arg Ser Pro Ala Lys Leu Ser Phe Gln Phe Pro Ser Ser Gly Ser Ala 
                85                  90                  95      


Gln Val His Ile Pro Ser Ile Ser Val Asp Gly Leu Ser Thr Pro Val 
            100                 105                 110         


Val Leu Ser Pro Gly Pro Gln Lys Pro 
        115                 120     


<210>  8473
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Elk-1__Homo_sapiens__BAC04259

<400>  8473
auggacaccg cagggcaggc gggcggccau gcggcuucca gcccugagau cucccagccg       60

cagaagggcc ggaagccccg ggaccuagag cuuccacuca gcccgagccu gcuagguggg      120

ccgggacccg aacggacccc aucccugcuu ccuacgcaua cauugacccc ggugcugcug      180

acacccagcu cgcugccucc uagcauucac uucuggagca cccugagucc cauugcgccc      240

cguagcccgg ccaagcucuc cuuccaguuu ccauccagug gcagcgccca ggugcacauc      300

ccuucuauca gcguggaugg ccucucgacc cccguggugc ucuccccagg gccccagaag      360

ccauga                                                                 366


<210>  8474
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Elk-1__Homo_sapiens__BAC04259

<400>  8474
auggacaccg ccggccaggc cgggggccac gccgccagcu cccccgagau cagccagccg       60

cagaaggggc gcaagccccg ggaccuggag cucccccugu cccccagccu gcucggcggg      120

ccgggccccg agcgcacccc cucccugcug cccacgcaca cccucacccc ggugcugcug      180

acccccagcu cccucccgcc cagcauccac uucuggucca cgcugagccc caucgcgccc      240

cggucccccg ccaagcugag cuuccaguuc cccuccagcg gcuccgccca gguccacauc      300

ccgagcaucu ccguggacgg gcucagcacc cccguggucc ugucccccgg cccccagaag      360

ccguga                                                                 366


<210>  8475
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Elk-1__Homo_sapiens__BAC04259

<400>  8475
auggacaccg ccggccaggc cggcggccac gccgccuccu cccccgagau cucccagccc       60

cagaagggcc gcaagccccg cgaccucgag cucccccucu cccccucccu ccucggcggc      120

cccggccccg agcgcacccc cucccuccuc cccacccaca cccucacccc cguccuccuc      180

acccccuccu cccucccccc cuccauccac uucuggucca cccucucccc caucgccccc      240

cgcucccccg ccaagcucuc cuuccaguuc cccuccuccg gcuccgccca gguccacauc      300

cccuccaucu ccgucgacgg ccucuccacc cccgucgucc ucucccccgg cccccagaag      360

cccuga                                                                 366


<210>  8476
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Elk-1__Homo_sapiens__BAC04259

<400>  8476
auggacaccg ccggccaggc ugggggacac gcagccagcu cccccgagau cucucaaccu       60

cagaagggua gaaaaccaag ggaucuggaa cucccgcuuu cacccagucu guugggcggg      120

ccuggaccag agcggacacc cagcuuacug ccuacucaua cgcuaacccc agugcuccug      180

acacccuccu cucuuccucc aucgauucac uucuggucaa cucugagccc gauagcgccc      240

cgcaguccug cuaaguuguc cuuucaguuc ccaucuagcg gcuccgccca gguccauauc      300

cccucaauua guguugacgg ucucagcacc ccugugguac ugucuccagg gccccaaaaa      360

ccguga                                                                 366


<210>  8477
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Elk-1__Homo_sapiens__BAC04259

<400>  8477
auggacaccg ccggccaggc cggcggccac gccgccagca gccccgagau cagccagccc       60

cagaagggca gaaagcccag agaccuggag cugccccuga gccccagccu gcugggcggc      120

cccggccccg agagaacccc cagccugcug cccacccaca cccugacccc cgugcugcug      180

acccccagca gccugccccc cagcauccac uucuggagca cccugagccc caucgccccc      240

agaagccccg ccaagcugag cuuccaguuc cccagcagcg gcagcgccca ggugcacauc      300

cccagcauca gcguggacgg ccugagcacc cccguggugc ugagccccgg cccccagaag      360

cccuga                                                                 366


<210>  8478
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Elk-1__Homo_sapiens__BAC04259

<400>  8478
auggacaccg ccggccaggc ugggggacac gccgcgagcu cccccgagau cucucaaccu       60

cagaagggca gaaaaccgcg ggaucuggaa cucccccuga gcccuucccu ucucggggga      120

cccggcccug agcgcacacc cucucugcug ccuacgcaua cccuuacacc ggugcugcuc      180

acccccagcu cccugccucc cucuauucac uucuggagca cacugucccc uaucgcuccc      240

agaagcccgg ccaagcucuc uuuucaguuc ccuuccagcg ggucugccca gguccauauu      300

cccuccauca gcguugacgg acugucuacc ccuguggugc uuucccccgg cccccaaaaa      360

ccuuga                                                                 366


<210>  8479
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ERK1__Homo_sapiens__P27361

<400>  8479

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  8480
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ERK1__Homo_sapiens__AAH13992

<400>  8480
auggcggcgg cggcggcuca ggggggcggg ggcggggagc cccguagaac cgaggggguc       60

ggcccggggg ucccggggga gguggagaug gugaaggggc agccguucga cgugggcccg      120

cgcuacacgc aguugcagua caucggcgag ggcgcguacg gcauggucag cucggccuau      180

gaccacgugc gcaagacucg cguggccauc aagaagauca gccccuucga acaucagacc      240

uacugccagc gcacgcuccg ggagauccag auccugcugc gcuuccgcca ugagaauguc      300

aucggcaucc gagacauucu gcgggcgucc acccuggaag ccaugagaga ugucuacauu      360

gugcaggacc ugauggagac ugaccuguac aaguugcuga aaagccagca gcugagcaau      420

gaccauaucu gcuacuuccu cuaccagauc cugcggggcc ucaaguacau ccacuccgcc      480

aacgugcucc accgagaucu aaagcccucc aaccugcuca ucaacaccac cugcgaccuu      540

aagauuugug auuucggccu ggcccggauu gccgauccug agcaugacca caccggcuuc      600

cugacggagu auguggcuac gcgcugguac cgggccccag agaucaugcu gaacuccaag      660

ggcuauacca aguccaucga caucuggucu gugggcugca uucuggcuga gaugcucucu      720

aaccggccca ucuucccugg caagcacuac cuggaucagc ucaaccacau ucugggcauc      780

cugggcuccc caucccagga ggaccugaau uguaucauca acaugaaggc ccgaaacuac      840

cuacagucuc ugcccuccaa gaccaaggug gcuugggcca agcuuuuccc caagucagac      900

uccaaagccc uugaccugcu ggaccggaug uuaaccuuua accccaauaa acggaucaca      960

guggaggaag cgcuggcuca ccccuaccug gagcaguacu augacccgac ggaugagcca     1020

guggccgagg agcccuucac cuucgccaug gagcuggaug accuaccuaa ggagcggcug     1080

aaggagcuca ucuuccagga gacagcacgc uuccagcccg gagugcugga ggcccccuag     1140


<210>  8481
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ERK1__Homo_sapiens__AAH13992

<400>  8481
auggccgccg cggccgccca gggcgggggc gggggcgagc cccgccggac cgagggggug       60

ggcccgggcg uccccgggga gguggagaug gugaagggcc agcccuucga cgucgggccc      120

cgcuacaccc agcugcagua caucggcgag ggggccuacg gcauggugag cuccgccuac      180

gaccacgugc ggaagacgcg cgucgcgauc aagaagauca gcccguucga gcaccagacc      240

uacugccagc ggacccuccg cgagauccag auccugcugc gguuccgcca cgagaacgug      300

aucggcaucc gggacauccu ccgcgccucc acccuggagg ccaugcggga cguguacauc      360

guccaggacc ugauggagac ggaccucuac aagcugcuca agagccagca gcucuccaac      420

gaccacaucu gcuacuuccu guaccagauc cugcgcgggc ucaaguacau ccacagcgcc      480

aacgugcugc accgggaccu gaagcccucc aaccuccuga ucaacacgac cugcgaccug      540

aagaucugcg acuucggccu cgcgcgcauc gccgaccccg agcacgacca caccggguuc      600

cugaccgagu acguggccac ccggugguac cgcgcccccg agaucaugcu gaacagcaag      660

ggcuacacca aguccaucga caucuggagc gucggcugca uccucgccga gaugcugucc      720

aaccggccga ucuuccccgg gaagcacuac cuggaccagc ucaaccacau ccugggcauc      780

cuggggagcc ccucccagga ggaccucaac ugcaucauca acaugaaggc gcgcaacuac      840

cugcagagcc ugcccuccaa gaccaaggug gccugggcca agcuguuccc caagagcgac      900

uccaaggccc uggaccugcu cgaccggaug cugacguuca acccgaacaa gcgcaucacc      960

guggaggagg cccuggcgca ccccuaccuc gagcaguacu acgaccccac cgacgagccg     1020

gucgccgagg agcccuucac cuucgccaug gagcuggacg accugcccaa ggagcggcuc     1080

aaggagcuga ucuuccagga gacggcccgc uuccagcccg gcgugcugga ggccccguga     1140


<210>  8482
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ERK1__Homo_sapiens__AAH13992

<400>  8482
auggccgccg ccgccgccca gggcggcggc ggcggcgagc cccgccgcac cgagggcguc       60

ggccccggcg uccccggcga ggucgagaug gucaagggcc agcccuucga cgucggcccc      120

cgcuacaccc agcuccagua caucggcgag ggcgccuacg gcauggucuc cuccgccuac      180

gaccacgucc gcaagacccg cgucgccauc aagaagaucu cccccuucga gcaccagacc      240

uacugccagc gcacccuccg cgagauccag auccuccucc gcuuccgcca cgagaacguc      300

aucggcaucc gcgacauccu ccgcgccucc acccucgagg ccaugcgcga cgucuacauc      360

guccaggacc ucauggagac cgaccucuac aagcuccuca agucccagca gcucuccaac      420

gaccacaucu gcuacuuccu cuaccagauc cuccgcggcc ucaaguacau ccacuccgcc      480

aacguccucc accgcgaccu caagcccucc aaccuccuca ucaacaccac cugcgaccuc      540

aagaucugcg acuucggccu cgcccgcauc gccgaccccg agcacgacca caccggcuuc      600

cucaccgagu acgucgccac ccgcugguac cgcgcccccg agaucaugcu caacuccaag      660

ggcuacacca aguccaucga caucuggucc gucggcugca uccucgccga gaugcucucc      720

aaccgcccca ucuuccccgg caagcacuac cucgaccagc ucaaccacau ccucggcauc      780

cucggcuccc ccucccagga ggaccucaac ugcaucauca acaugaaggc ccgcaacuac      840

cuccaguccc uccccuccaa gaccaagguc gccugggcca agcucuuccc caaguccgac      900

uccaaggccc ucgaccuccu cgaccgcaug cucaccuuca accccaacaa gcgcaucacc      960

gucgaggagg cccucgccca ccccuaccuc gagcaguacu acgaccccac cgacgagccc     1020

gucgccgagg agcccuucac cuucgccaug gagcucgacg accuccccaa ggagcgccuc     1080

aaggagcuca ucuuccagga gaccgcccgc uuccagcccg gcguccucga ggcccccuga     1140


<210>  8483
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ERK1__Homo_sapiens__AAH13992

<400>  8483
auggccgcug cagccgcgca gggcggggga gguggcgagc ccagaaggac cgaaggggug       60

ggaccuggcg ucccagguga gguugaaaug gugaaggggc aaccguucga cguaggaccc      120

cgguacacac agcugcagua uaucggcgag ggcgcuuacg ggauggugag cuccgccuau      180

gaucacgucc gcaaaacucg aguggcaauu aagaaaauau cuccuuuuga acaucagacg      240

uacugccaac guacccucag agagauccag auucuucuga gguuccggca cgagaacguu      300

aucgguauuc gcgacaucuu gagagccuca acauuagaag cuaugaggga uguguauaua      360

guccaggacc ugauggagac ugaucuauac aagcuccuga aaagucagca acuuagcaau      420

gaccauaucu guuauuuucu guaccagauu uugcggggac ucaaguacau ccacuccgca      480

aacgugcugc aucgcgaucu gaagccaucu aaucucuuaa uuaacaccac augcgaccug      540

aaaaucugug auuucggccu ugcccgaaua gcugaccccg aacacgauca caccggguuu      600

uugacugagu auguagccac aagaugguac agggcgccug agauuauguu aaauucgaag      660

ggauauacca aaucaaucga cauuuggagc guuggcugca uccuagcaga aaugcucagu      720

aaccggccaa ucuuccccgg uaagcauuac cuggaucagc uuaaucacau ucuggggaua      780

uugggauccc cuucucagga ggaccucaac uguaucauua auaugaaagc ccguaacuau      840

cugcaaagcc ugccauccaa gacgaaggug gcuugggcca aacuguuucc gaagucagac      900

aguaaagcac ucgaucuucu ggaccgcaug uugacuuuca aucccaacaa gagaaucacc      960

gucgaagagg cucuagccca uccuuaccug gaacaguauu acgauccaac agacgagccc     1020

guggcggagg aaccuuuuac uuucgccaug gagcucgaug accugccaaa agaaaggcuu     1080

aaggagcuga uauuucagga aaccgcacgg uuccaacccg gcguguugga ggcuccguga     1140


<210>  8484
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ERK1__Homo_sapiens__AAH13992

<400>  8484
auggccgccg ccgccgccca gggcggcggc ggcggcgagc ccagaagaac cgagggcgug       60

ggccccggcg ugcccggcga gguggagaug gugaagggcc agcccuucga cgugggcccc      120

agauacaccc agcugcagua caucggcgag ggcgccuacg gcauggugag cagcgccuac      180

gaccacguga gaaagaccag aguggccauc aagaagauca gccccuucga gcaccagacc      240

uacugccaga gaacccugag agagauccag auccugcuga gauucagaca cgagaacgug      300

aucggcauca gagacauccu gagagccagc acccuggagg ccaugagaga cguguacauc      360

gugcaggacc ugauggagac cgaccuguac aagcugcuga agagccagca gcugagcaac      420

gaccacaucu gcuacuuccu guaccagauc cugagaggcc ugaaguacau ccacagcgcc      480

aacgugcugc acagagaccu gaagcccagc aaccugcuga ucaacaccac cugcgaccug      540

aagaucugcg acuucggccu ggccagaauc gccgaccccg agcacgacca caccggcuuc      600

cugaccgagu acguggccac cagaugguac agagcccccg agaucaugcu gaacagcaag      660

ggcuacacca agagcaucga caucuggagc gugggcugca uccuggccga gaugcugagc      720

aacagaccca ucuuccccgg caagcacuac cuggaccagc ugaaccacau ccugggcauc      780

cugggcagcc ccagccagga ggaccugaac ugcaucauca acaugaaggc cagaaacuac      840

cugcagagcc ugcccagcaa gaccaaggug gccugggcca agcuguuccc caagagcgac      900

agcaaggccc uggaccugcu ggacagaaug cugaccuuca accccaacaa gagaaucacc      960

guggaggagg cccuggccca ccccuaccug gagcaguacu acgaccccac cgacgagccc     1020

guggccgagg agcccuucac cuucgccaug gagcuggacg accugcccaa ggagagacug     1080

aaggagcuga ucuuccagga gaccgccaga uuccagcccg gcgugcugga ggcccccuga     1140


<210>  8485
<211>  1140
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ERK1__Homo_sapiens__AAH13992

<400>  8485
auggccgcug ccgcggcuca gggcggggga ggcggggagc ccagacggac cgaaggagug       60

ggcccugggg ucccgggaga gguugaaaug gugaagggcc aacccuucga cgugggcccu      120

cgcuacacac agcugcagua uaucggggag ggagccuacg gcauggucag cuccgccuau      180

gaucacguga gaaaaacgcg gguugcuauu aagaaaaucu cucccuuuga acaucagacc      240

uacugccaac gcacacucag agagauucag auccugcuuc gguuccgcca cgagaacgug      300

auugggauca gagacauccu gcgggccagc acccucgaag cuaugcgcga ugucuauauu      360

gugcaggacc ugauggagac agaucuuuac aagcugcuca aaucccagca acugucuaau      420

gaccauaucu guuauuuucu guaccagauu cucagaggac ugaaguacau ccacagcgcc      480

aacguucuuc aucgggaucu gaagccuucc aaucuccuga uuaacaccac augcgaccuu      540

aaaaucugug auuucggccu ggcgcgcauu gccgaccccg aacacgauca caccggguuu      600

cucacggagu auguggcuac cagaugguac cgggccccug agaucaugcu caauucuaag      660

ggauauacaa aaagcaucga cauuuggucc gucggcugca uccuggcuga aaugcugagc      720

aaccgcccga uuuuccccgg caagcauuac cuggaucagc uuaaucacau ccuggggauu      780

cucggaucuc cuucccagga ggaccugaac uguaucauca auaugaaagc cagaaacuau      840

cuucaaagcc ugcccucuaa gaccaaggug gcgugggcca aacucuuucc uaaguccgac      900

agcaaagcuc uggaucugcu cgaccggaug cugacauuca aucccaacaa gagaauuacc      960

guggaagagg cccuugcuca uccguaccug gaacaguauu acgauccuac ggacgagccc     1020

gucgccgagg aaccuuuuac auucgccaug gagcucgaug accugcccaa agaacgccuu     1080

aaggagcuga ucuuucagga aaccgcucgg uuccaacccg gcguucucga ggcgccuuga     1140


<210>  8486
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ERK2__Homo_sapiens__P28482

<400>  8486

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  8487
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  ERK2__Homo_sapiens__AAA58459

<400>  8487
auggcggcgg cggcggcggc gggcgcgggc ccggagaugg uccgcgggca gguguucgac       60

guggggccgc gcuacaccaa ccucucguac aucggcgagg gcgccuacgg cauggugugc      120

ucugcuuaug auaaugucaa caaaguucga guagcuauca agaaaaucag ccccuuugag      180

caccagaccu acugccagag aacccugagg gagauaaaaa ucuuacugcg cuucagacau      240

gagaacauca uuggaaucaa ugacauuauu cgagcaccaa ccaucgagca aaugaaagau      300

guauauauag uacaggaccu cauggaaaca gaucuuuaca agcucuugaa gacacaacac      360

cucagcaaug accauaucug cuauuuucuc uaccagaucc ucagaggguu aaaauauauc      420

cauucagcua acguucugca ccgugaccuc aagccuucca accugcugcu caacaccacc      480

ugugaucuca agaucuguga cuuuggccug gcccguguug cagauccaga ccaugaucac      540

acaggguucc ugacagaaua uguggccaca cguugguaca gggcuccaga aauuauguug      600

aauuccaagg gcuacaccaa guccauugau auuuggucug uaggcugcau ucuggcagaa      660

augcuuucca acaggcccau cuuuccaggg aagcauuauc uugaccagcu gaaucacauu      720

uuggguauuc uuggaucccc aucacaagaa gaccugaauu guauaauaaa uuuaaaagcu      780

aggaacuauu ugcuuucucu uccacacaaa aauaaggugc cauggaacag gcuguuccca      840

aaugcugacu ccaaagcucu ggacuuauug gacaaaaugu ugacauucaa cccacacaag      900

aggauugaag uagaacaggc ucuggcccac ccauaucugg agcaguauua cgacccgagu      960

gacgagccca ucgccgaagc accauucaag uucgacaugg aauuggauga cuugccuaag     1020

gaaaagcuaa aagaacuaau uuuugaagag acugcuagau uccagccagg auacagaucu     1080

uaa                                                                   1083


<210>  8488
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       ERK2__Homo_sapiens__AAA58459

<400>  8488
auggccgccg cggccgccgc cggcgccggg cccgagaugg ugcgcggcca ggucuucgac       60

guggggccgc gguacaccaa ccugagcuac aucggcgagg gggcguacgg cauggugugc      120

uccgccuacg acaacgucaa caaggugcgc guggccauca agaagaucag ccccuucgag      180

caccagaccu acugccagcg gacgcuccgc gagaucaaga uccugcugcg guuccgccac      240

gagaacauca ucggcaucaa cgacaucauc cgggccccca ccaucgagca gaugaaggac      300

gucuacaucg ugcaggaccu cauggagacc gaccuguaca agcugcucaa gacccagcac      360

cuguccaacg accacaucug cuacuuccug uaccagaucc uccgcgggcu gaaguacauc      420

cacagcgcga acgugcugca ccgggaccuc aagcccucca accugcugcu caacacgacc      480

ugcgaccuga agaucugcga cuucggccug gcccgcgucg ccgacccgga ccacgaccac      540

accggguucc ucaccgagua cguggccacg cggugguacc gcgcccccga gaucaugcug      600

aacagcaagg gcuacaccaa guccaucgac aucuggagcg uggggugcau ccuggcggag      660

augcucucca accggcccau cuuccccggc aagcacuacc uggaccagcu gaaccacauc      720

cucggcaucc uggggagccc gucccaggag gaccugaacu gcaucaucaa ccucaaggcc      780

cgcaacuacc ugcugagccu cccccacaag aacaaggucc ccuggaaccg gcuguucccc      840

aacgccgacu ccaaggcccu ggaccuccug gacaagaugc ugaccuucaa cccgcacaag      900

cgcaucgagg uggagcaggc ccucgcgcac cccuaccugg agcaguacua cgaccccagc      960

gacgagccca ucgccgaggc cccguucaag uucgacaugg agcuggacga ccuccccaag     1020

gagaagcuga aggagcugau cuucgaggag accgcccggu uccagcccgg cuaccgcucc     1080

uga                                                                   1083


<210>  8489
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       ERK2__Homo_sapiens__AAA58459

<400>  8489
auggccgccg ccgccgccgc cggcgccggc cccgagaugg uccgcggcca ggucuucgac       60

gucggccccc gcuacaccaa ccucuccuac aucggcgagg gcgccuacgg cauggucugc      120

uccgccuacg acaacgucaa caagguccgc gucgccauca agaagaucuc ccccuucgag      180

caccagaccu acugccagcg cacccuccgc gagaucaaga uccuccuccg cuuccgccac      240

gagaacauca ucggcaucaa cgacaucauc cgcgccccca ccaucgagca gaugaaggac      300

gucuacaucg uccaggaccu cauggagacc gaccucuaca agcuccucaa gacccagcac      360

cucuccaacg accacaucug cuacuuccuc uaccagaucc uccgcggccu caaguacauc      420

cacuccgcca acguccucca ccgcgaccuc aagcccucca accuccuccu caacaccacc      480

ugcgaccuca agaucugcga cuucggccuc gcccgcgucg ccgaccccga ccacgaccac      540

accggcuucc ucaccgagua cgucgccacc cgcugguacc gcgcccccga gaucaugcuc      600

aacuccaagg gcuacaccaa guccaucgac aucugguccg ucggcugcau ccucgccgag      660

augcucucca accgccccau cuuccccggc aagcacuacc ucgaccagcu caaccacauc      720

cucggcaucc ucggcucccc cucccaggag gaccucaacu gcaucaucaa ccucaaggcc      780

cgcaacuacc uccucucccu cccccacaag aacaaggucc ccuggaaccg ccucuucccc      840

aacgccgacu ccaaggcccu cgaccuccuc gacaagaugc ucaccuucaa cccccacaag      900

cgcaucgagg ucgagcaggc ccucgcccac cccuaccucg agcaguacua cgaccccucc      960

gacgagccca ucgccgaggc ccccuucaag uucgacaugg agcucgacga ccuccccaag     1020

gagaagcuca aggagcucau cuucgaggag accgcccgcu uccagcccgg cuaccgcucc     1080

uga                                                                   1083


<210>  8490
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       ERK2__Homo_sapiens__AAA58459

<400>  8490
auggccgcug cagccgcggc uggcgccggg cccgagaugg ugagaggaca ggucuucgac       60

guugguccua gguacaccaa ccugagcuau aucggcgaag gggcauacgg aauggugugc      120

uccgccuaug auaauguaaa caaggugcgg gucgcuauua aaaagauauc uccauuugag      180

caccaaacau acugucagcg cacucuccga gaaaucaaaa uucuucugcg uuucagacau      240

gagaauauca uuggcaucaa cgacauaauc agggcaccga cgauugaaca gaugaaggau      300

guguauaucg uucaggacuu gauggagacc gauuuauaca aacugcuaaa gacacaacac      360

cucucaaaug accauauuug cuauuuucug uaccagaucc uucggggucu gaaguacaua      420

cacagugcca acguguugca ucgcgaucuc aaacccagca aucugcugcu caacacuacc      480

ugugacuuaa agauuugcga uuucgggcug gcuagagucg ccgacccuga ucacgaccac      540

acaggauuuc uuaccgagua uguggcgacu aggugguacc gggcaccaga aaucauguug      600

aacuccaaag gcuauacaaa gucuauugau aucuggucgg uaggcuguau ccuggccgag      660

augcuaucaa aucgccccau uuucccuggg aaacauuacc ucgaccagcu gaaucacaua      720

cuuggaaucc uggguagccc aagucaggaa gacuugaacu gcauuaucaa ucucaaggcu      780

cgaaacuauc uguuaucccu gccccauaag aauaaaguuc cuuggaacag acucuuucca      840

aacgccgauu cuaaggcacu ugaccuguug gauaaaaugc uaaccuucaa uccgcacaag      900

aggauagagg uggagcaagc ucuggcccac cccuaccucg aacaguauua cgacccuagc      960

gaugagccaa uugcggaagc ccccuuuaaa uucgacaugg agcuggauga ccuuccuaag     1020

gaaaaacuga aggaguugau cuuugaggaa acggcacggu uccagccagg cuaccguucc     1080

uga                                                                   1083


<210>  8491
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       ERK2__Homo_sapiens__AAA58459

<400>  8491
auggccgccg ccgccgccgc cggcgccggc cccgagaugg ugagaggcca gguguucgac       60

gugggcccca gauacaccaa ccugagcuac aucggcgagg gcgccuacgg cauggugugc      120

agcgccuacg acaacgugaa caaggugaga guggccauca agaagaucag ccccuucgag      180

caccagaccu acugccagag aacccugaga gagaucaaga uccugcugag auucagacac      240

gagaacauca ucggcaucaa cgacaucauc agagccccca ccaucgagca gaugaaggac      300

guguacaucg ugcaggaccu gauggagacc gaccuguaca agcugcugaa gacccagcac      360

cugagcaacg accacaucug cuacuuccug uaccagaucc ugagaggccu gaaguacauc      420

cacagcgcca acgugcugca cagagaccug aagcccagca accugcugcu gaacaccacc      480

ugcgaccuga agaucugcga cuucggccug gccagagugg ccgaccccga ccacgaccac      540

accggcuucc ugaccgagua cguggccacc agaugguaca gagcccccga gaucaugcug      600

aacagcaagg gcuacaccaa gagcaucgac aucuggagcg ugggcugcau ccuggccgag      660

augcugagca acagacccau cuuccccggc aagcacuacc uggaccagcu gaaccacauc      720

cugggcaucc ugggcagccc cagccaggag gaccugaacu gcaucaucaa ccugaaggcc      780

agaaacuacc ugcugagccu gccccacaag aacaaggugc ccuggaacag acuguucccc      840

aacgccgaca gcaaggcccu ggaccugcug gacaagaugc ugaccuucaa cccccacaag      900

agaaucgagg uggagcaggc ccuggcccac cccuaccugg agcaguacua cgaccccagc      960

gacgagccca ucgccgaggc ccccuucaag uucgacaugg agcuggacga ccugcccaag     1020

gagaagcuga aggagcugau cuucgaggag accgccagau uccagcccgg cuacagaagc     1080

uga                                                                   1083


<210>  8492
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       ERK2__Homo_sapiens__AAA58459

<400>  8492
auggccgcug ccgcggcugc cggcgccggg cccgagaugg ugagaggaca ggucuucgac       60

guuggcccuc gguacaccaa ccugagcuau aucggggaag gagcuuacgg cauggugugc      120

uccgccuaug auaaugugaa caagguccgc guggcuauua aaaagaucuc uccguuugag      180

caccaaacau acugucagag aacgcuccgg gaaauuaaaa uccugcuucg cuucagacau      240

gagaauauua ucgggaucaa cgacauuauc cgggccccca ccauugaaca gaugaaggau      300

guuuauaucg ugcaggaccu gauggagaca gaucucuaca aacugcuuaa gacccaacac      360

cugagcaaug accauauuug cuauuuucuc uaccagaucc ugcgcggacu gaaguacauu      420

cacuccgcga acguccucca uagagaucug aaaccuucua aucuucugcu caacacaacc      480

ugugaccuga agaucugcga uuucggccuu gcccgggugg cugaccccga ucacgaccac      540

acaggcuuuc ugaccgagua uguugccacg cgcugguaca gagcuccuga aaucaugcuc      600

aauagcaaag gguauaccaa guccauugau aucuggucug ugggauguau ucuggccgag      660

augcugagca accggcccau cuucccuggc aaacauuacc ucgaccagcu gaaucacauu      720

cuugggaucc ugggaucccc gagccaggaa gaccucaacu gcaucauuaa ucugaaggcg      780

cgcaacuauc uucugucucu cccccauaag aauaaagucc cuuggaacag acuguuuccc      840

aacgccgauu ccaaggcucu ggaccuccug gauaaaaugc uuacauucaa uccucacaag      900

cggaucgagg uggagcaagc ccuggcucac cccuaccucg aacaguauua cgacccgagc      960

gaugagccua uugccgaagc ccccuuuaaa uucgacaugg agcuggauga ccuuccuaag     1020

gaaaaacuga aggagcucau cuuugaggaa accgcucgcu uccagcccgg cuacagaucu     1080

uga                                                                   1083


<210>  8493
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__A0A024R8B4

<400>  8493

Met Gly Gly Ala Ala Gln Leu Glu Asp Arg Pro Arg Asp Lys Pro Gln 
1               5                   10                  15      


Thr Asn Gln Pro Arg Cys 
            20          


<210>  8494
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__EAW87951

<400>  8494
augggcggcg cugcccaacu ugaggaccgg ccgcgcgaca agccgcagac aaaucagccc       60

cguugcuga                                                               69


<210>  8495
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__EAW87951

<400>  8495
augggcgggg ccgcccagcu ggaggaccgc ccccgggaca agccgcagac caaccagccc       60

cgcugcuga                                                               69


<210>  8496
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__EAW87951

<400>  8496
augggcggcg ccgcccagcu cgaggaccgc ccccgcgaca agccccagac caaccagccc       60

cgcugcuga                                                               69


<210>  8497
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__EAW87951

<400>  8497
augggcgggg ccgcucagcu ggaggacaga cccagggaua agccucaaac caaccagcca       60

cggugcuga                                                               69


<210>  8498
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__EAW87951

<400>  8498
augggcggcg ccgcccagcu ggaggacaga cccagagaca agccccagac caaccagccc       60

agaugcuga                                                               69


<210>  8499
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__EAW87951

<400>  8499
augggcgggg ccgcucagcu ggaggacaga ccccgggaua agccucaaac caaccagccg       60

cgcugcuga                                                               69


<210>  8500
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__A4D1B8

<400>  8500

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu 
        195                 200                 205             


Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser 
    210                 215                 220                 


Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val 
225                 230                 235                 240 


Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala 
                245                 250                 255     


Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys 
            260                 265                 270         


Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys 
        275                 280                 285             


Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu 
    290                 295                 300                 


Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr 
305                 310                 315                 320 


Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn 
                325                 330                 335     


Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp 
            340                 345                 350         


Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser 
        355                 360                 365             


Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys 
    370                 375                 380                 


Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly 
385                 390                 395                 400 


Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala 
                405                 410                 415     


His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile 
            420                 425                 430         


Arg Pro Lys His Phe Lys Pro 
        435                 


<210>  8501
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__BAG35554

<400>  8501
augaagcugg cuaacuggua cuggcugagc ucagcuguuc uugccacuua cgguuuuuug       60

guuguggcaa acaaugaaac agaggaaauu aaagaugaaa gagcaaagga ugucugccca      120

gugagacuag aaagcagagg gaaaugcgaa gaggcagggg agugccccua ccagguaagc      180

cugccccccu ugacuauuca gcucccgaag caauucagca ggaucgagga gguguucaaa      240

gaaguccaaa accucaagga aaucguaaau agucuaaaga aaucuugcca agacugcaag      300

cugcaggcug augacaacgg agacccaggc agaaacggac uguuguuacc caguacagga      360

gccccgggag agguugguga uaacagaguu agagaauuag agagugaggu uaacaagcug      420

uccucugagc uaaagaaugc caaagaggag aucaauguac uucauggucg ccuggagaag      480

cugaaucuug uaaauaugaa caacauagaa aauuauguug acagcaaagu ggcaaaucua      540

acauuuguug ucaauaguuu ggauggcaaa uguucaaagu gucccagcca agaacaaaua      600

cagucacguc caguucaaca ucuaauauau aaagauugcu cugacuacua cgcaauaggc      660

aaaagaagca gugagaccua cagaguuaca ccugauccca aaaauaguag cuuugaaguu      720

uacugugaca uggagaccau ggggggaggc uggacagugc ugcaggcacg ccucgauggg      780

agcaccaacu ucaccagaac auggcaagac uacaaagcag gcuuuggaaa ccucagaagg      840

gaauuuuggc uggggaacga uaaaauucau cuucugacca agaguaagga aaugauucug      900

agaauagauc uugaagacuu uaaugguguc gaacuauaug ccuuguauga ucaguuuuau      960

guggcuaaug aguuucucaa auaucguuua cacguuggua acuauaaugg cacagcugga     1020

gaugcauuac guuucaacaa acauuacaac cacgaucuga aguuuuucac cacuccagau     1080

aaagacaaug aucgauaucc uucugggaac ugugggcugu acuacaguuc aggcuggugg     1140

uuugaugcau gucuuucugc aaacuuaaau ggcaaauauu aucaccaaaa auacagaggu     1200

guccguaaug ggauuuucug ggguaccugg ccugguguaa gugaggcaca cccugguggc     1260

uacaaguccu ccuucaaaga ggcuaagaug augaucagac ccaagcacuu uaagccauaa     1320


<210>  8502
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__BAG35554

<400>  8502
augaagcugg ccaacuggua cuggcucagc uccgccgugc uggcgaccua cggcuuccug       60

gucguggcca acaacgagac cgaggagauc aaggacgagc gcgccaagga cgugugcccc      120

guccggcucg agagccgcgg gaagugcgag gaggccggcg agugcccgua ccaggugucc      180

cugccgcccc ugacgaucca gcuccccaag caguucagcc ggaucgagga gguguucaag      240

gagguccaga accugaagga gaucgugaac ucccugaaga aguccugcca ggacugcaag      300

cuccaggccg acgacaacgg ggaccccggc cgcaacgggc ugcugcuccc cagcaccggc      360

gcgcccggcg agguggggga caaccggguc cgcgagcugg agagcgaggu gaacaagcug      420

uccagcgagc ucaagaacgc caaggaggag aucaacgugc ugcacggccg gcuggagaag      480

cucaaccugg ucaacaugaa caacaucgag aacuacgugg acuccaaggu ggccaaccug      540

accuucgucg ugaacagccu cgacgggaag ugcuccaagu gccccagcca ggagcagauc      600

cagucccgcc cggugcagca ccugaucuac aaggacugca gcgacuacua cgccaucggc      660

aagcggucca gcgagaccua ccgcgucacg cccgacccca agaacuccag cuucgaggug      720

uacugcgaca uggagaccau gggcgggggc uggaccgugc ugcaggcgcg gcucgacggg      780

agcaccaacu ucacgcgcac cuggcaggac uacaaggccg gcuucgggaa ccugcggcgc      840

gaguucuggc ugggcaacga caagauccac cuccugacca aguccaagga gaugauccug      900

cggaucgacc ucgaggacuu caacggcguc gagcuguacg cccuguacga ccaguucuac      960

guggccaacg aguuccucaa guaccgccug cacgugggga acuacaacgg caccgccggg     1020

gacgcgcugc gguucaacaa gcacuacaac cacgaccuca aguucuucac gacccccgac     1080

aaggacaacg accgcuaccc gagcggcaac ugcgggcugu acuacuccag cggcuggugg     1140

uucgacgccu gccuguccgc caaccucaac ggcaaguacu accaccagaa guaccgcggg     1200

guccggaacg gcaucuucug ggggaccugg cccggcguga gcgaggccca ccccgggggc     1260

uacaagucca gcuucaagga ggccaagaug augauccggc ccaagcacuu caagccguga     1320


<210>  8503
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__BAG35554

<400>  8503
augaagcucg ccaacuggua cuggcucucc uccgccgucc ucgccaccua cggcuuccuc       60

gucgucgcca acaacgagac cgaggagauc aaggacgagc gcgccaagga cgucugcccc      120

guccgccucg agucccgcgg caagugcgag gaggccggcg agugccccua ccaggucucc      180

cucccccccc ucaccaucca gcuccccaag caguucuccc gcaucgagga ggucuucaag      240

gagguccaga accucaagga gaucgucaac ucccucaaga aguccugcca ggacugcaag      300

cuccaggccg acgacaacgg cgaccccggc cgcaacggcc uccuccuccc cuccaccggc      360

gcccccggcg aggucggcga caaccgcguc cgcgagcucg aguccgaggu caacaagcuc      420

uccuccgagc ucaagaacgc caaggaggag aucaacgucc uccacggccg ccucgagaag      480

cucaaccucg ucaacaugaa caacaucgag aacuacgucg acuccaaggu cgccaaccuc      540

accuucgucg ucaacucccu cgacggcaag ugcuccaagu gccccuccca ggagcagauc      600

cagucccgcc ccguccagca ccucaucuac aaggacugcu ccgacuacua cgccaucggc      660

aagcgcuccu ccgagaccua ccgcgucacc cccgacccca agaacuccuc cuucgagguc      720

uacugcgaca uggagaccau gggcggcggc uggaccgucc uccaggcccg ccucgacggc      780

uccaccaacu ucacccgcac cuggcaggac uacaaggccg gcuucggcaa ccuccgccgc      840

gaguucuggc ucggcaacga caagauccac cuccucacca aguccaagga gaugauccuc      900

cgcaucgacc ucgaggacuu caacggcguc gagcucuacg cccucuacga ccaguucuac      960

gucgccaacg aguuccucaa guaccgccuc cacgucggca acuacaacgg caccgccggc     1020

gacgcccucc gcuucaacaa gcacuacaac cacgaccuca aguucuucac cacccccgac     1080

aaggacaacg accgcuaccc cuccggcaac ugcggccucu acuacuccuc cggcuggugg     1140

uucgacgccu gccucuccgc caaccucaac ggcaaguacu accaccagaa guaccgcggc     1200

guccgcaacg gcaucuucug gggcaccugg cccggcgucu ccgaggccca ccccggcggc     1260

uacaaguccu ccuucaagga ggccaagaug augauccgcc ccaagcacuu caagcccuga     1320


<210>  8504
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__BAG35554

<400>  8504
augaagcugg ccaacuggua cuggcucagc uccgcugugc uugcaaccua uggcuuccug       60

gucguugcca auaacgagac agaagagauc aaagacgaaa gagcgaagga ugugugcccc      120

guaagguugg agucucgggg gaaaugugaa gaggcuggag agugcccuua ccagguguca      180

uuaccaccgc ugacuauuca acuacccaag caguuuaguc gcauagaaga ggucuucaaa      240

gaagugcaga aucucaagga gaucguuaac agccugaaga aauccuguca ggacugcaaa      300

cuucaagccg augacaaugg ugauccuggc cgaaacgggc uguugcuccc aucuacggga      360

gcacccggcg agguggguga caaucguguc agagaacugg agucggaagu gaacaagcug      420

ucaagcgagc ucaagaaugc caaagaagag auuaacguau uacacgggag gcuggagaaa      480

cuuaauuugg uuaacaugaa uaacaucgaa aauuaugugg auaguaaggu cgcuaaccug      540

accuuugugg ugaacucccu agacggaaag uguucuaagu gcccuagcca ggagcagauu      600

cagucccggc caguccaaca ucucaucuac aaagauuguu cagacuauua cgcaauaggc      660

aagcgcagua gcgaaacaua uagaguuacu cccgauccua aaaauucuuc cuucgaggug      720

uacugcgaca uggaaaccau gggcggggga uggacaguac ugcaggccag gcuugauggu      780

ucaaccaacu uuacucggac auggcaggac uacaaggcug gcuucgggaa ucugcgccga      840

gaguuuuggu ugggaaacga caaaauccac cuccugacca agagcaagga gaugauuuua      900

agaaucgauc uggaagacuu caauggcgug gagcucuaug cccuuuacga ucaguuuuau      960

gucgcgaacg aguuccugaa auacagguug caugugggua auuauaacgg gacggcagga     1020

gacgcccuac gguuuaauaa gcacuacaac caugaucuga aauucuuuac uaccccagac     1080

aaggauaaug accguuaucc gaguggcaac uguggccucu acuacucuuc cggguggugg     1140

uucgaugcuu gccugagcgc caaucuuaac ggaaaauauu accaccaaaa guaucgcggu     1200

guuagaaaug gcauuuucug ggggacaugg cccggagugu cggaagcaca cccuggcggu     1260

uacaagucuu ccuuuaaaga agcuaagaug augaucaggc caaaacauuu caagcccuga     1320


<210>  8505
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__BAG35554

<400>  8505
augaagcugg ccaacuggua cuggcugagc agcgccgugc uggccaccua cggcuuccug       60

gugguggcca acaacgagac cgaggagauc aaggacgaga gagccaagga cgugugcccc      120

gugagacugg agagcagagg caagugcgag gaggccggcg agugccccua ccaggugagc      180

cugccccccc ugaccaucca gcugcccaag caguucagca gaaucgagga gguguucaag      240

gaggugcaga accugaagga gaucgugaac agccugaaga agagcugcca ggacugcaag      300

cugcaggccg acgacaacgg cgaccccggc agaaacggcc ugcugcugcc cagcaccggc      360

gcccccggcg aggugggcga caacagagug agagagcugg agagcgaggu gaacaagcug      420

agcagcgagc ugaagaacgc caaggaggag aucaacgugc ugcacggcag acuggagaag      480

cugaaccugg ugaacaugaa caacaucgag aacuacgugg acagcaaggu ggccaaccug      540

accuucgugg ugaacagccu ggacggcaag ugcagcaagu gccccagcca ggagcagauc      600

cagagcagac ccgugcagca ccugaucuac aaggacugca gcgacuacua cgccaucggc      660

aagagaagca gcgagaccua cagagugacc cccgacccca agaacagcag cuucgaggug      720

uacugcgaca uggagaccau gggcggcggc uggaccgugc ugcaggccag acuggacggc      780

agcaccaacu ucaccagaac cuggcaggac uacaaggccg gcuucggcaa ccugagaaga      840

gaguucuggc ugggcaacga caagauccac cugcugacca agagcaagga gaugauccug      900

agaaucgacc uggaggacuu caacggcgug gagcuguacg cccuguacga ccaguucuac      960

guggccaacg aguuccugaa guacagacug cacgugggca acuacaacgg caccgccggc     1020

gacgcccuga gauucaacaa gcacuacaac cacgaccuga aguucuucac cacccccgac     1080

aaggacaacg acagauaccc cagcggcaac ugcggccugu acuacagcag cggcuggugg     1140

uucgacgccu gccugagcgc caaccugaac ggcaaguacu accaccagaa guacagaggc     1200

gugagaaacg gcaucuucug gggcaccugg cccggcguga gcgaggccca ccccggcggc     1260

uacaagagca gcuucaagga ggccaagaug augaucagac ccaagcacuu caagcccuga     1320


<210>  8506
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__BAG35554

<400>  8506
augaagcugg ccaacuggua cuggcucagc uccgcugugc uggccaccua uggcuuccuu       60

gucguugcga auaacgagac agaagagauc aaagacgaaa gagcuaagga ugugugcccc      120

gugcggcugg agucucgcgg gaaaugugaa gaggccggag agugcccuua ccaggucagc      180

cucccgcccc ugacgauuca acuuccuaag caguuuucca gaaucgaaga gguguucaaa      240

gaaguucaga aucugaagga gauugugaac ucucucaaga aaagcuguca ggacugcaag      300

cugcaagccg augacaaugg cgaucccggg cggaacggac ugcuccugcc uuccaccggc      360

gcucccgggg aggucggaga caaucgcgug agagaacuug agucugaagu uaacaaacug      420

agcuccgagc ucaagaaugc caaagaagag aucaacgugc ugcacggccg gcuugagaag      480

cugaaucucg ucaacaugaa uaacauugaa aauuaugugg auagcaaggu ggcuaaccug      540

acauuugucg uuaacucucu ggacggcaaa uguuccaagu gcccuagcca ggagcagauc      600

cagucucgcc cggugcaaca ucucaucuac aaagauuguu ccgacuauua cgccauuggg      660

aagagaagcu cugaaaccua ucgggugaca cccgauccua aaaauuccag cuucgagguc      720

uacugcgaca uggaaaccau gggaggcggg uggacagugc ugcaggcgcg ccuugaugga      780

uccaccaacu uuacgagaac cuggcaggac uacaaggccg gcuucgggaa ucugcggcgc      840

gaguuuuggc ucggaaacga caaaauccau cugcuuacaa agucuaagga gaugauucug      900

agaaucgauc ucgaagacuu caauggcguu gagcuguaug cucuguacga ucaguuuuau      960

guggccaacg aguuccucaa auaccggcug cacgucggca auuauaacgg gaccgcugga     1020

gacgcccuuc gcuuuaauaa gcacuacaac caugaucuga aauucuuuac aacccccgac     1080

aaggauaaug acagauaucc uagcggcaac ugugggcucu acuacuccag cggauggugg     1140

uucgaugcgu gccugucugc caaucuuaac ggcaaauauu accaccaaaa guauagaggg     1200

gugcggaaug gaauuuucug gggcacgugg cccggcguuu ccgaagcuca cccuggggga     1260

uacaagagcu cuuuuaaaga agccaagaug augauccgcc cgaaacauuu caagcccuga     1320


<210>  8507
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__A8K8X4

<400>  8507

Met Val Asn Asp Arg Trp Lys Thr Met Gly Gly Ala Ala Gln Leu Glu 
1               5                   10                  15      


Asp Arg Pro Arg Asp Lys Pro Gln Arg Pro Ser Cys Gly Tyr Val Leu 
            20                  25                  30          


Cys Thr Val Leu Leu Ala Leu Ala Val Leu Leu Ala Val Ala Val Thr 
        35                  40                  45              


Gly Ala Val Leu Phe Leu Asn His Ala His Ala Pro Gly Thr Ala Pro 
    50                  55                  60                  


Pro Pro Val Val Ser Thr Gly Ala Ala Gly Ala Asn Ser Ala Leu Val 
65                  70                  75                  80  


Thr Val Glu Arg Ala Asp Ser Ser His Leu Ser Ile Leu Ile Asp Pro 
                85                  90                  95      


Arg Cys Pro Asp Leu Thr Asp Ser Phe Ala Arg Leu Glu Ser Ala Gln 
            100                 105                 110         


Ala Ser Val Leu Gln Ala Leu Thr Glu His Gln Ala Gln Pro Arg Leu 
        115                 120                 125             


Val Gly Asp Gln Glu Gln Glu Leu Leu Asp Thr Leu Ala Asp Gln Leu 
    130                 135                 140                 


Pro Arg Leu Leu Ala Arg Ala Ser Glu Leu Gln Thr Glu Cys Met Gly 
145                 150                 155                 160 


Leu Arg Lys Gly His Gly Thr Leu Gly Gln Gly Leu Ser Ala Leu Gln 
                165                 170                 175     


Ser Glu Gln Gly Arg Leu Ile Gln Leu Leu Ser Glu Ser Gln Gly His 
            180                 185                 190         


Met Ala His Leu Val Asn Ser Val Ser Asp Ile Leu Asp Ala Leu Gln 
        195                 200                 205             


Arg Asp Arg Gly Leu Gly Arg Pro Arg Asn Lys Ala Asp Leu Gln Arg 
    210                 215                 220                 


Ala Pro Ala Arg Gly Thr Arg Pro Arg Gly Cys Ala Thr Gly Ser Arg 
225                 230                 235                 240 


Pro Arg Asp Cys Leu Asp Val Leu Leu Ser Gly Gln Gln Asp Asp Gly 
                245                 250                 255     


Val Tyr Ser Val Phe Pro Thr His Tyr Pro Ala Gly Phe Gln Val Tyr 
            260                 265                 270         


Cys Asp Met Arg Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg 
        275                 280                 285             


Glu Asp Gly Ser Val Asn Phe Phe Arg Gly Trp Asp Ala Tyr Arg Asp 
    290                 295                 300                 


Gly Phe Gly Arg Leu Thr Gly Glu His Trp Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


His Ala Leu Thr Thr Gln Ala Ala Tyr Glu Leu His Val Asp Leu Glu 
                325                 330                 335     


Asp Phe Glu Asn Gly Thr Ala Tyr Ala Arg Tyr Gly Ser Phe Gly Val 
            340                 345                 350         


Gly Leu Phe Ser Val Asp Pro Glu Glu Asp Gly Tyr Pro Leu Thr Val 
        355                 360                 365             


Ala Asp Tyr Ser Gly Thr Ala Gly Asp Ser Leu Leu Lys His Ser Gly 
    370                 375                 380                 


Met Arg Phe Thr Thr Lys Asp Arg Asp Ser Asp His Ser Glu Asn Asn 
385                 390                 395                 400 


Cys Ala Ala Phe Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys His Thr 
                405                 410                 415     


Ser Asn Leu Asn Gly Gln Tyr Leu Arg Gly Ala His Ala Ser Tyr Ala 
            420                 425                 430         


Asp Gly Val Glu Trp Ser Ser Trp Thr Gly Trp Gln Tyr Ser Leu Lys 
        435                 440                 445             


Phe Ser Glu Met Lys Ile Arg Pro Val Arg Glu Asp Arg 
    450                 455                 460     


<210>  8508
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__BAF85178

<400>  8508
auggucaacg accgguggaa gaccaugggc ggcgcugccc aacuugagga ccggccgcgc       60

gacaagccgc agcggccgag cugcggcuac gugcugugca ccgugcugcu ggcccuggcu      120

gugcugcugg cuguagcugu caccggugcc gugcucuucc ugaaccacgc ccacgcgccg      180

ggcacggcgc ccccaccugu cgucagcacu ggggcugccg gcgccaacag cgcccugguc      240

acuguggaaa gggcggacag cucgcaccuc agcauccuca uugacccgcg cugccccgac      300

cucaccgaca gcuucgcacg ccuggagagc gcccaggccu cggugcugca ggcgcugaca      360

gagcaccagg cccagccacg gcuggugggc gaccaggagc aggagcugcu ggacacgcug      420

gccgaccagc ugccccggcu gcuggcccga gccucagagc ugcagacgga gugcaugggg      480

cugcggaagg ggcauggcac gcugggccag ggccucagcg cccugcagag ugagcagggc      540

cgccucaucc agcuucucuc ugagagccag ggccacaugg cucaccuggu gaacuccguc      600

agcgacaucc uggaugcccu gcagagggac cgggggcugg gccggccccg caacaaggcc      660

gaccuucaga gagcgccugc ccggggaacc cggccccggg gcugugccac uggcucccgg      720

ccccgagacu gucuggacgu ccuccuaagc ggacagcagg acgauggcgu cuacucuguc      780

uuucccaccc acuacccggc cggcuuccag guguacugug acaugcgcac ggacggcggc      840

ggcuggacgg uguuucagcg ccgggaggac ggcuccguga acuucuuccg gggcugggac      900

gcguaccgag acggcuuugg caggcucacc ggggagcacu ggcuagggcu caagaggauc      960

cacgcccuga ccacacaggc ugccuacgag cugcacgugg accuggagga cuuugagaau     1020

ggcacggccu augcccgcua cgggagcuuc ggcgugggcu uguucuccgu ggacccugag     1080

gaagacgggu acccgcucac cguggcugac uauuccggca cugcaggcga cucccuccug     1140

aagcacagcg gcaugagguu caccaccaag gaccgugaca gcgaccauuc agagaacaac     1200

ugugccgccu ucuaccgcgg ugccuggugg uaccgcaacu gccacacguc caaccucaau     1260

gggcaguacc ugcgcggugc gcacgccucc uaugccgacg gcguggagug guccuccugg     1320

accggcuggc aguacucacu caaguucucu gagaugaaga uccggccggu ccgggaggac     1380

cgcuag                                                                1386


<210>  8509
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__BAF85178

<400>  8509
auggugaacg accgcuggaa gaccaugggc ggggccgccc agcuggagga ccggccccgc       60

gacaagccgc agcggcccag cugcggcuac guccucugca ccgugcugcu ggcgcucgcc      120

gugcugcugg ccgucgccgu gacgggggcc guccucuucc ugaaccacgc gcacgccccc      180

ggcaccgcgc ccccgcccgu gguguccacc ggggccgccg gcgccaacag cgcccuggug      240

accgucgagc gcgccgacuc cagccaccuc uccauccuga ucgacccccg gugccccgac      300

cugacggaca gcuucgcccg ccucgagucc gcgcaggcca gcgugcugca ggcccugacc      360

gagcaccagg cccagccgcg gcucgugggc gaccaggagc aggagcugcu ggacacccuc      420

gccgaccagc ugccccgccu gcucgcgcgg gccuccgagc ugcagaccga gugcaugggg      480

cugcgcaagg gccacgggac gcucggccag gggcugagcg cccugcaguc cgagcagggc      540

cggcucaucc agcugcugag cgagucccag ggccacaugg cccaccucgu caacagcgug      600

uccgacaucc uggacgcccu gcagcgcgac cgggggcucg gccgcccccg gaacaaggcg      660

gaccugcagc gcgcccccgc ccgggggacc cgcccgcggg gcugcgccac cggcagccgc      720

ccccgggacu gccuggacgu gcuccugucc gggcagcagg acgacggcgu cuacagcgug      780

uuccccaccc acuaccccgc cggguuccag guguacugcg acaugcgcac ggacggcggg      840

ggcuggaccg ucuuccagcg ccgggaggac ggcuccguga acuucuuccg cgggugggac      900

gcguaccggg acggcuucgg gcgccugacc ggcgagcacu ggcucgggcu gaagcggauc      960

cacgcccuga ccacgcaggc cgccuacgag cuccacgugg accuggagga cuucgagaac     1020

ggcaccgcgu acgcccgcua cggcagcuuc ggggucggcc uguucagcgu ggacccggag     1080

gaggacgggu acccccucac cguggccgac uacuccggca ccgccgggga cagccugcug     1140

aagcacuccg gcaugcgguu cacgaccaag gaccgcgaca gcgaccacuc cgagaacaac     1200

ugcgccgcgu ucuaccgggg cgccuggugg uaccgcaacu gccacaccag caaccucaac     1260

gggcaguacc ugcggggcgc ccacgccucc uacgccgacg gggucgagug gagcuccugg     1320

accggcuggc aguacagccu gaaguucucc gagaugaaga uccgccccgu gcgggaggac     1380

cgcuga                                                                1386


<210>  8510
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__BAF85178

<400>  8510
auggucaacg accgcuggaa gaccaugggc ggcgccgccc agcucgagga ccgcccccgc       60

gacaagcccc agcgccccuc cugcggcuac guccucugca ccguccuccu cgcccucgcc      120

guccuccucg ccgucgccgu caccggcgcc guccucuucc ucaaccacgc ccacgccccc      180

ggcaccgccc ccccccccgu cgucuccacc ggcgccgccg gcgccaacuc cgcccucguc      240

accgucgagc gcgccgacuc cucccaccuc uccauccuca ucgacccccg cugccccgac      300

cucaccgacu ccuucgcccg ccucgagucc gcccaggccu ccguccucca ggcccucacc      360

gagcaccagg cccagccccg ccucgucggc gaccaggagc aggagcuccu cgacacccuc      420

gccgaccagc ucccccgccu ccucgcccgc gccuccgagc uccagaccga gugcaugggc      480

cuccgcaagg gccacggcac ccucggccag ggccucuccg cccuccaguc cgagcagggc      540

cgccucaucc agcuccucuc cgagucccag ggccacaugg cccaccucgu caacuccguc      600

uccgacaucc ucgacgcccu ccagcgcgac cgcggccucg gccgcccccg caacaaggcc      660

gaccuccagc gcgcccccgc ccgcggcacc cgcccccgcg gcugcgccac cggcucccgc      720

ccccgcgacu gccucgacgu ccuccucucc ggccagcagg acgacggcgu cuacuccguc      780

uuccccaccc acuaccccgc cggcuuccag gucuacugcg acaugcgcac cgacggcggc      840

ggcuggaccg ucuuccagcg ccgcgaggac ggcuccguca acuucuuccg cggcugggac      900

gccuaccgcg acggcuucgg ccgccucacc ggcgagcacu ggcucggccu caagcgcauc      960

cacgcccuca ccacccaggc cgccuacgag cuccacgucg accucgagga cuucgagaac     1020

ggcaccgccu acgcccgcua cggcuccuuc ggcgucggcc ucuucuccgu cgaccccgag     1080

gaggacggcu acccccucac cgucgccgac uacuccggca ccgccggcga cucccuccuc     1140

aagcacuccg gcaugcgcuu caccaccaag gaccgcgacu ccgaccacuc cgagaacaac     1200

ugcgccgccu ucuaccgcgg cgccuggugg uaccgcaacu gccacaccuc caaccucaac     1260

ggccaguacc uccgcggcgc ccacgccucc uacgccgacg gcgucgagug guccuccugg     1320

accggcuggc aguacucccu caaguucucc gagaugaaga uccgccccgu ccgcgaggac     1380

cgcuga                                                                1386


<210>  8511
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__BAF85178

<400>  8511
auggugaacg acagauggaa gaccaugggc ggggccgcuc agcuggagga uaggccccgg       60

gacaaaccuc aacgcccaag cugcggauac guccucugua caguucuucu ggcauuggcc      120

guguuacugg cgguagcugu gacuggugcc guccuauucc ucaaucacgc acaugccccg      180

ggcacggcuc ccccuccagu gguuuccacc ggggcagccg gagcuaacuc ugcccuggug      240

acagucgaac gagcggauuc aagucaccuu agcauccuga uugacccccg uugcccugau      300

uugacugacu ccuuugcaag acucgagucu gcccaggcuu cggugcugca ggcccugacc      360

gaacaucagg cacaaccaag gcucguaggc gaucaggagc aggaauuacu ggacacacuu      420

gcugaucagu ugccccggcu gcuagcccgc gcgucagagc uccaaaccga guguaugggu      480

cugagaaagg ggcacggaac ucuuggccag ggccugagcg ccuugcagag ugaacagggg      540

aggcucauac aacuguuauc cgagucucag ggacauaugg cacaccuggu uaauagcgug      600

uccgacaucc ucgaugcccu ucagcgggac cgcggucugg gccgaccuag aaacaaagcu      660

gauuugcaaa gggcuccagc ccgggggaca cguccgcgcg gaugcgcaac cggcucaaga      720

cccagggacu gucuagacgu ccugcucagu ggucagcagg augacggggu guauagcgug      780

uucccuacgc acuacccagc cggauuucag gucuauugcg auaugcggac ugacggcggc      840

ggguggaccg uuuuccaacg acgcgaagau ggaucuguga acuuuuucag agguugggac      900

gcuuacaggg auggcuuugg gcggcugaca ggagagcauu ggcuuggccu gaagcgcauu      960

cacgcguuga cuacccaggc agccuaugag cuccauguag accuggaaga uuucgagaau     1020

gguacagcuu acgccagaua uggguccuuu ggcgugggau uauucucagu cgaccccgaa     1080

gaggauggcu acccucugac cguggcagac uacagcggga cggccggaga cagucuacuc     1140

aaacacucug guaugagguu uacuacaaag gaucgugacu ccgaucacag cgaaaauaac     1200

ugugcugccu ucuaucgggg cgcauggugg uaccgaaauu gccauaccuc gaaccugaau     1260

gggcaguauc uuagaggagc gcacgcuucu uacgccgacg gcguugagug guccucaugg     1320

acugguuggc aguauaguuu gaaguuuagc gagaugaaaa ucaggccagu gcgcgaagau     1380

cgguga                                                                1386


<210>  8512
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__BAF85178

<400>  8512
auggugaacg acagauggaa gaccaugggc ggcgccgccc agcuggagga cagacccaga       60

gacaagcccc agagacccag cugcggcuac gugcugugca ccgugcugcu ggcccuggcc      120

gugcugcugg ccguggccgu gaccggcgcc gugcuguucc ugaaccacgc ccacgccccc      180

ggcaccgccc ccccccccgu ggugagcacc ggcgccgccg gcgccaacag cgcccuggug      240

accguggaga gagccgacag cagccaccug agcauccuga ucgaccccag augccccgac      300

cugaccgaca gcuucgccag acuggagagc gcccaggcca gcgugcugca ggcccugacc      360

gagcaccagg cccagcccag acuggugggc gaccaggagc aggagcugcu ggacacccug      420

gccgaccagc ugcccagacu gcuggccaga gccagcgagc ugcagaccga gugcaugggc      480

cugagaaagg gccacggcac ccugggccag ggccugagcg cccugcagag cgagcagggc      540

agacugaucc agcugcugag cgagagccag ggccacaugg cccaccuggu gaacagcgug      600

agcgacaucc uggacgcccu gcagagagac agaggccugg gcagacccag aaacaaggcc      660

gaccugcaga gagcccccgc cagaggcacc agacccagag gcugcgccac cggcagcaga      720

cccagagacu gccuggacgu gcugcugagc ggccagcagg acgacggcgu guacagcgug      780

uuccccaccc acuaccccgc cggcuuccag guguacugcg acaugagaac cgacggcggc      840

ggcuggaccg uguuccagag aagagaggac ggcagcguga acuucuucag aggcugggac      900

gccuacagag acggcuucgg cagacugacc ggcgagcacu ggcugggccu gaagagaauc      960

cacgcccuga ccacccaggc cgccuacgag cugcacgugg accuggagga cuucgagaac     1020

ggcaccgccu acgccagaua cggcagcuuc ggcgugggcc uguucagcgu ggaccccgag     1080

gaggacggcu acccccugac cguggccgac uacagcggca ccgccggcga cagccugcug     1140

aagcacagcg gcaugagauu caccaccaag gacagagaca gcgaccacag cgagaacaac     1200

ugcgccgccu ucuacagagg cgccuggugg uacagaaacu gccacaccag caaccugaac     1260

ggccaguacc ugagaggcgc ccacgccagc uacgccgacg gcguggagug gagcagcugg     1320

accggcuggc aguacagccu gaaguucagc gagaugaaga ucagacccgu gagagaggac     1380

agauga                                                                1386


<210>  8513
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__BAF85178

<400>  8513
auggugaacg acagauggaa gaccaugggc ggggccgcuc agcuggagga ucggccccgc       60

gacaaaccuc aaagaccgag cugcggauac guccucugua caguucugcu ugcccuggcg      120

gugcuccugg cuguggccgu cacgggcgcc gugcuuuucc ugaaucacgc ucaugccccc      180

gggaccgcuc cucccccugu uguguccaca ggagccgcgg gcgccaacuc ugcucucguc      240

accguggaac gggccgauag cucccaccug ucuauccuga uugacccccg cugcccugau      300

cucacagaca gcuuugcuag acuggagucc gcccaggcgu cuguucuuca ggcccugacc      360

gaacaucagg cucaaccgcg gcucgugggg gaucaggagc aggaacugcu ugacacacug      420

gccgaucagc ucccccgccu gcuggcuaga gccagcgagc uccaaaccga guguauggga      480

cugcggaagg gccacggcac gcuugggcag ggacuguccg cccuccagag cgaacagggc      540

cgccugaucc aacuucuguc ugagucccag gggcauaugg cucaccucgu caauagcgug      600

ucugacauuc uggaugcgcu gcagagagac cggggacucg gccgcccuag aaacaaagcc      660

gaucugcaac gggcucccgc ccgcgggacc agaccucggg gaugcgccac aggcuccaga      720

ccccgcgacu gucuugacgu gcugcucagc ggccagcagg augacggggu cuauucuguu      780

uucccgaccc acuacccugc uggauuucag guguauugcg auaugcggac agacggcggg      840

ggauggaccg uguuccaaag acgcgaagau ggcuccguca acuuuuuccg ggggugggac      900

gccuacagag auggauuugg ccgccugacg ggcgagcauu ggcuugggcu gaagcggauc      960

cacgcgcuca caacccaggc ugccuaugag cugcaugugg accuggaaga uuucgagaau     1020

ggaacagccu acgcuagaua uggcagcuuu gggguuggac ucuucuccgu ggaccccgaa     1080

gaggauggcu acccucugac cgucgccgac uacucuggga ccgcuggcga cagccuucug     1140

aaacacuccg gaaugcgcuu uacaacgaag gaucgggaca gcgaucacuc ugaaaauaac     1200

ugugccgcgu ucuauagagg cgccuggugg uaccgcaauu gccauaccuc caaccucaau     1260

gggcaguauc ugcggggagc ucacgccagc uacgcugacg gcguggagug gucuagcugg     1320

acaggguggc aguauucccu gaaguuuucu gagaugaaaa uuagacccgu ucgggaagau     1380

cgcuga                                                                1386


<210>  8514
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__B4DTN2

<400>  8514

Met Val Asn Asp Arg Trp Lys Thr Met Gly Gly Ala Ala Gln Leu Glu 
1               5                   10                  15      


Asp Arg Pro Arg Asp Lys Pro Gln Ala Arg Lys Leu Arg Leu Arg Glu 
            20                  25                  30          


Arg Pro Ser Cys Gly Tyr Val Leu Cys Thr Val Leu Leu Ala Leu Ala 
        35                  40                  45              


Val Leu Leu Ala Val Ala Val Thr Gly Ala Val Leu Phe Leu Asn His 
    50                  55                  60                  


Ala His Ala Pro Gly Thr Ala Pro Pro Pro Val Val Ser Thr Gly Ala 
65                  70                  75                  80  


Ala Ser Ala Asn Ser Ala Leu Val Thr Val Glu Arg Ala Asp Ser Ser 
                85                  90                  95      


His Leu Ser Ile Leu Ile Asp Pro Arg Cys Pro Asp Leu Thr Asp Ser 
            100                 105                 110         


Phe Ala Arg Leu Glu Ser Ala Gln Ala Ser Val Leu Gln Ala Leu Thr 
        115                 120                 125             


Glu His Gln Ala Gln Pro Arg Leu Val Gly Asp Gln Glu Gln Glu Leu 
    130                 135                 140                 


Leu Asp Thr Leu Ala Asp Gln Leu Pro Arg Leu Leu Ala Arg Ala Ser 
145                 150                 155                 160 


Glu Leu Gln Thr Glu Cys Met Gly Leu Arg Lys Gly His Gly Thr Leu 
                165                 170                 175     


Glu Arg Arg 
            


<210>  8515
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__BAG62044

<400>  8515
auggucaacg accgguggaa gaccaugggc ggcgcugccc aacuugagga ccggccgcgc       60

gacaagccgc aggcgaggaa acugaggcuc agagagcggc cgagcugcgg cuacgugcug      120

ugcaccgugc ugcuggcccu ggcugugcug cuggcuguag cugucaccgg ugccgugcuc      180

uuccugaacc acgcccacgc gccgggcacg gcgcccccac cugucgucag cacuggggcu      240

gccagcgcca acagcgcccu ggucacugug gaaagggcgg acagcucgca ccucagcauc      300

cucauugacc cgcgcugccc cgaccucacc gacagcuucg cacgccugga gagcgcccag      360

gccucggugc ugcaggcgcu gacagagcac caggcccagc cacggcuggu gggcgaccag      420

gagcaggagc ugcuggacac gcuggccgac cagcugcccc ggcugcuggc ccgagccuca      480

gagcugcaga cggagugcau ggggcugcgg aaggggcaug gcacgcugga aaggcgguaa      540


<210>  8516
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__BAG62044

<400>  8516
auggugaacg accgcuggaa gaccaugggc ggggccgccc agcuggagga ccggccccgc       60

gacaagccgc aggcgcggaa gcuccgccug cgggagcgcc ccagcugcgg cuacguccug      120

ugcaccgugc uccuggcccu ggccgugcuc cuggccgucg ccgugacggg ggcggugcug      180

uuccucaacc acgcccacgc ccccggcacc gcgcccccgc ccgucguguc caccggggcc      240

gccagcgcca acuccgcccu ggugaccguc gagcgggccg acagcuccca ccugagcauc      300

cucaucgacc cccgcugccc cgaccugacg gacuccuucg cgcggcugga gagcgcccag      360

gccuccgugc uccaggcccu gaccgagcac caggcccagc cgcgccuggu gggcgaccag      420

gagcaggagc uccuggacac ccuggcggac cagcuccccc ggcugcuggc ccgcgccagc      480

gagcuccaga ccgagugcau gggccugcgg aaggggcacg gcacgcugga gcgccgguga      540


<210>  8517
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__BAG62044

<400>  8517
auggucaacg accgcuggaa gaccaugggc ggcgccgccc agcucgagga ccgcccccgc       60

gacaagcccc aggcccgcaa gcuccgccuc cgcgagcgcc ccuccugcgg cuacguccuc      120

ugcaccgucc uccucgcccu cgccguccuc cucgccgucg ccgucaccgg cgccguccuc      180

uuccucaacc acgcccacgc ccccggcacc gccccccccc ccgucgucuc caccggcgcc      240

gccuccgcca acuccgcccu cgucaccguc gagcgcgccg acuccuccca ccucuccauc      300

cucaucgacc cccgcugccc cgaccucacc gacuccuucg cccgccucga guccgcccag      360

gccuccgucc uccaggcccu caccgagcac caggcccagc cccgccucgu cggcgaccag      420

gagcaggagc uccucgacac ccucgccgac cagcuccccc gccuccucgc ccgcgccucc      480

gagcuccaga ccgagugcau gggccuccgc aagggccacg gcacccucga gcgccgcuga      540


<210>  8518
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__BAG62044

<400>  8518
auggugaacg acagauggaa gaccaugggc ggggccgcuc agcuggagga uaggccccgg       60

gacaaaccuc aagcacgcaa gcuccgacuu cgugaaagac caagcugcgg auacguccug      120

uguacaguuu uguuagcccu ggcggugcua cucgcuguag ccgugacugg ugcaguccug      180

uuccuuaauc acgcccaugc uccgggcacg gcacccccuc cagugguuuc caccggggcc      240

gcuucugcca acucagcgcu ggugacaguc gagagggcag auaguagcca cuuguccauc      300

cucauugacc cccggugccc ugaucugacu gacucuuuug cccgccugga aucggcucag      360

gccucagugc uccaggcauu aaccgagcau caggcucaac caagacuggu aggagaucag      420

gaacaggagc uuuuggacac acuggccgau cagcuaccca ggcuccuggc gcgggccagc      480

gagcuucaaa ccgaauguau gggccugcgc aaaggucacg ggacuuugga gcgaagauga      540


<210>  8519
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__BAG62044

<400>  8519
auggugaacg acagauggaa gaccaugggc ggcgccgccc agcuggagga cagacccaga       60

gacaagcccc aggccagaaa gcugagacug agagagagac ccagcugcgg cuacgugcug      120

ugcaccgugc ugcuggcccu ggccgugcug cuggccgugg ccgugaccgg cgccgugcug      180

uuccugaacc acgcccacgc ccccggcacc gccccccccc ccguggugag caccggcgcc      240

gccagcgcca acagcgcccu ggugaccgug gagagagccg acagcagcca ccugagcauc      300

cugaucgacc ccagaugccc cgaccugacc gacagcuucg ccagacugga gagcgcccag      360

gccagcgugc ugcaggcccu gaccgagcac caggcccagc ccagacuggu gggcgaccag      420

gagcaggagc ugcuggacac ccuggccgac cagcugccca gacugcuggc cagagccagc      480

gagcugcaga ccgagugcau gggccugaga aagggccacg gcacccugga gagaagauga      540


<210>  8520
<211>  540
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__BAG62044

<400>  8520
auggugaacg acagauggaa gaccaugggc ggggccgcuc agcuggagga ucggccccgc       60

gacaaaccuc aagccagaaa gcuccggcug cgcgaaagac cgagcugcgg auacguccuu      120

uguacaguuc ugcucgcgcu ggcugugcuu cuggccgugg ccgucacggg cgcuguucuc      180

uuccugaauc acgcccaugc ucccgggacc gccccucccc cugugguguc cacaggagcg      240

gccucugcua acagcgcccu ggucaccgug gagcgggcug auuccucuca ccucagcauc      300

cugauugacc cccgcugccc ugaucuuaca gacuccuuug ccagacugga aucugcgcag      360

gccagcguuc uccaggcucu gaccgagcau caggcccaac cgcggcuugu gggcgaucag      420

gaacaggagc ugcucgacac acuggcugau cagcugcccc gccuccuggc cagagccucc      480

gagcuucaaa ccgaauguau ggggcugcgg aaaggacacg gcacgcucga gcgcagauga      540


<210>  8521
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__B4E1D3

<400>  8521

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Arg Pro Ala Lys Ala Ala Ala Thr 
    50                  55                  60                  


Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu His 
65                  70                  75                  80  


Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu Gln 
                85                  90                  95      


Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp Glu 
            100                 105                 110         


Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser Phe 
        115                 120                 125             


Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys Gln 
    130                 135                 140                 


Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu Glu 
145                 150                 155                 160 


Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro Thr 
                165                 170                 175     


Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys Ile 
            180                 185                 190         


Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg Thr 
        195                 200                 205             


Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu Cys 
    210                 215                 220                 


Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu Ile 
225                 230                 235                 240 


Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met Asn 
                245                 250                 255     


Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly Ser 
            260                 265                 270         


Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly Asn 
        275                 280                 285             


Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly Glu 
    290                 295                 300                 


Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly Pro 
305                 310                 315                 320 


Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val Lys 
                325                 330                 335     


Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr Gln 
            340                 345                 350         


Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met Asp 
        355                 360                 365             


Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His Asn 
    370                 375                 380                 


Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu Thr 
385                 390                 395                 400 


Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp Trp 
                405                 410                 415     


Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp Gly 
            420                 425                 430         


Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly Val 
        435                 440                 445             


Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met Ser 
    450                 455                 460                 


Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
465                 470                 


<210>  8522
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__BAG64745

<400>  8522
augaaaagga ugguuucuug gagcuuccac aaacuuaaaa ccaugaaaca ucuauuauug       60

cuacuauugu guguuuuucu aguuaagucc caagguguca acgacaauga ggaggguuuc      120

uucagugccc guggucaucg accccuugac aagaagagag aagaggcucg uccagccaaa      180

gcagcugcca cucaaaagaa aguagaaaga aaagccccug augcuggagg cugucuucac      240

gcugacccag accugggggu guuguguccu acaggauguc aguugcaaga ggcuuugcua      300

caacaggaaa ggccaaucag aaauaguguu gaugaguuaa auaacaaugu ggaagcuguu      360

ucccagaccu ccucuucuuc cuuucaguac auguauuugc ugaaagaccu guggcaaaag      420

aggcagaagc aaguaaaaga uaaugaaaau guagucaaug aguacuccuc agaacuggaa      480

aagcaccaau uauauauaga ugagacugug aauagcaaua ucccaacuaa ccuucgugug      540

cuucguucaa uccuggaaaa ccugagaagc aaaauacaaa aguuagaauc ugaugucuca      600

gcucaaaugg aauauugucg caccccaugc acugucaguu gcaauauucc uguggugucu      660

ggcaaagaau gugaggaaau uaucaggaaa ggaggugaaa caucugaaau guaucucauu      720

caaccugaca guucugucaa accguauaga guauacugug acaugaauac agaaaaugga      780

ggauggacag ugauucagaa ccgucaagac gguaguguug acuuuggcag gaaaugggau      840

ccauauaaac agggauuugg aaauguugca accaacacag augggaagaa uuacuguggc      900

cuaccaggug aauauuggcu uggaaaugau aaaauuagcc agcuuaccag gaugggaccc      960

acagaacuuu ugauagaaau ggaggacugg aaaggagaca aaguaaaggc ucacuaugga     1020

ggauucacug uacagaauga agccaacaaa uaccagaucu cagugaacaa auacagagga     1080

acagccggua augcccucau ggauggagca ucucagcuga ugggagaaaa caggaccaug     1140

accauucaca acggcauguu cuucagcacg uaugacagag acaaugacgg cugguuaaca     1200

ucagauccca gaaaacagug uucuaaagaa gacgguggug gaugguggua uaauagaugu     1260

caugcagcca auccaaacgg cagauacuac ugggguggac aguacaccug ggacauggca     1320

aagcauggca cagaugaugg uguaguaugg augaauugga aggggucaug guacucaaug     1380

aggaagauga guaugaagau caggcccuuc uucccacagc aauag                     1425


<210>  8523
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__BAG64745

<400>  8523
augaagcgca uggugagcug guccuuccac aagcugaaga ccaugaagca ccuccugcug       60

cuccugcugu gcgucuuccu cgucaagagc cagggcguga acgacaacga ggagggguuc      120

uucuccgccc ggggccaccg cccccuggac aagaagcggg aggaggcccg cccggcgaag      180

gccgccgcca cccagaagaa gguggagcgg aaggcccccg acgccggggg cugccugcac      240

gcggaccccg accucggggu gcugugcccc acgggcugcc agcugcagga ggcccuccug      300

cagcaggagc gcccgauccg gaacagcgug gacgagcuga acaacaacgu cgaggccgug      360

ucccagacca gcuccagcuc cuuccaguac auguaccucc ugaaggaccu guggcagaag      420

cgccagaagc aggucaagga caacgagaac guggugaacg aguacagcuc cgagcucgag      480

aagcaccagc uguacaucga cgagaccgug aacagcaaca uccccaccaa ccugcggguc      540

cuccgcucca uccuggagaa ccugcggagc aagauccaga agcucgaguc cgacgugagc      600

gcgcagaugg aguacugccg cacgcccugc accguguccu gcaacauccc cgucgugagc      660

ggcaaggagu gcgaggagau cauccggaag ggcggggaga ccuccgagau guaccugauc      720

cagccggaca gcagcgugaa gcccuaccgc gucuacugcg acaugaacac cgagaacggg      780

ggcuggacgg ugauccagaa ccggcaggac ggguccgugg acuucggccg caagugggac      840

cccuacaagc agggcuucgg gaacgucgcc accaacaccg acggcaagaa cuacugcggg      900

cugcccggcg aguacuggcu cggcaacgac aagaucagcc agcugacccg gauggggccg      960

acggagcugc ucaucgagau ggaggacugg aagggcgaca aggugaaggc ccacuacggg     1020

ggcuucaccg ugcagaacga ggccaacaag uaccagaucu ccgucaacaa guaccgcggg     1080

accgccggca acgcgcugau ggacggcgcc agccagcuga ugggggagaa ccggaccaug     1140

acgauccaca acggcauguu cuucuccacc uacgaccgcg acaacgacgg guggcucacc     1200

agcgaccccc ggaagcagug cuccaaggag gacggcgggg gcugguggua caaccgcugc     1260

cacgccgcca accccaacgg ccgcuacuac uggggcgggc aguacaccug ggacauggcc     1320

aagcacggga cggacgacgg cguggucugg augaacugga aggggagcug guacuccaug     1380

cggaagauga gcaugaagau ccgccccuuc uucccgcagc aguga                     1425


<210>  8524
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__BAG64745

<400>  8524
augaagcgca uggucuccug guccuuccac aagcucaaga ccaugaagca ccuccuccuc       60

cuccuccucu gcgucuuccu cgucaagucc cagggcguca acgacaacga ggagggcuuc      120

uucuccgccc gcggccaccg cccccucgac aagaagcgcg aggaggcccg ccccgccaag      180

gccgccgcca cccagaagaa ggucgagcgc aaggcccccg acgccggcgg cugccuccac      240

gccgaccccg accucggcgu ccucugcccc accggcugcc agcuccagga ggcccuccuc      300

cagcaggagc gccccauccg caacuccguc gacgagcuca acaacaacgu cgaggccguc      360

ucccagaccu ccuccuccuc cuuccaguac auguaccucc ucaaggaccu cuggcagaag      420

cgccagaagc aggucaagga caacgagaac gucgucaacg aguacuccuc cgagcucgag      480

aagcaccagc ucuacaucga cgagaccguc aacuccaaca uccccaccaa ccuccgcguc      540

cuccgcucca uccucgagaa ccuccgcucc aagauccaga agcucgaguc cgacgucucc      600

gcccagaugg aguacugccg cacccccugc accgucuccu gcaacauccc cgucgucucc      660

ggcaaggagu gcgaggagau cauccgcaag ggcggcgaga ccuccgagau guaccucauc      720

cagcccgacu ccuccgucaa gcccuaccgc gucuacugcg acaugaacac cgagaacggc      780

ggcuggaccg ucauccagaa ccgccaggac ggcuccgucg acuucggccg caagugggac      840

cccuacaagc agggcuucgg caacgucgcc accaacaccg acggcaagaa cuacugcggc      900

cuccccggcg aguacuggcu cggcaacgac aagaucuccc agcucacccg caugggcccc      960

accgagcucc ucaucgagau ggaggacugg aagggcgaca aggucaaggc ccacuacggc     1020

ggcuucaccg uccagaacga ggccaacaag uaccagaucu ccgucaacaa guaccgcggc     1080

accgccggca acgcccucau ggacggcgcc ucccagcuca ugggcgagaa ccgcaccaug     1140

accauccaca acggcauguu cuucuccacc uacgaccgcg acaacgacgg cuggcucacc     1200

uccgaccccc gcaagcagug cuccaaggag gacggcggcg gcugguggua caaccgcugc     1260

cacgccgcca accccaacgg ccgcuacuac uggggcggcc aguacaccug ggacauggcc     1320

aagcacggca ccgacgacgg cgucgucugg augaacugga agggcuccug guacuccaug     1380

cgcaagaugu ccaugaagau ccgccccuuc uucccccagc aguga                     1425


<210>  8525
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__BAG64745

<400>  8525
augaagagaa uggugagcug guccuuccac aaacugaaga ccaugaaaca ucuccuucug       60

uuguuacugu gcgucuuucu aguuaagucu cagggcguga acgacaauga ggaaggguuc      120

uuuucagcca ggggacaccg gccccucgau aaaaagcgcg aggaagcucg accugcaaag      180

gccgcggcua cacaaaagaa gguagagcgu aaagccccag acgccggugg cugucugcau      240

gcagauccgg accuuggggu gcugugcccc acuggauguc aguugcagga agcucuccug      300

cagcaagaga gaccuaucag gaacaguguc gaugagcuga auaacaaugu ggaagcaguu      360

agccagacgu ccucuucguc auuccaguac auguaucucu uaaaggaccu guggcagaaa      420

cggcaaaaac aggugaagga uaacgagaau gucgugaacg aauacagcag ugagcuugag      480

aaacaccagu uguauauuga cgaaaccgua aauuccaaca uaccaacaaa ucugcgcguu      540

cuaagaucua uccucgagaa ccugaggagc aagauucaga aacuugaauc cgauguguca      600

gcccaaaugg aguacugccg gacucccugu accgucaguu gcaauauccc uguggugagc      660

ggcaaggaau gugaggagau uauccgcaaa gguggggaaa caucugagau guaucugaua      720

cagccagacu ccucagucaa gcccuaccga guuuauugcg auaugaacac cgaaaaugga      780

ggcuggacug ugauccagaa cagacaagac ggcagcguag auuuugggag gaaaugggac      840

ccuuacaagc agggauucgg uaacguggcu acaaauaccg acggcaagaa cuacuguggg      900

uugccaggag aguauuggcu cggcaaugau aaaauuaguc agcugacgcg gauggguccg      960

acugaauuac ugaucgagau ggaggacugg aagggggaua aagucaaggc ccauuacgga     1020

ggcuuuaccg ugcagaacga agcgaauaaa uaucaaauuu cuguuaacaa guaccguggc     1080

acagcaggga augcccucau ggacggagcu ucccagcuua ugggugagaa ccgcacuaug     1140

accauccaca auggcauguu cuuuagcaca uaugauagag acaacgaugg guggcugacc     1200

ucggacccca ggaagcagug cucuaaagaa gauggaggcg guugguggua caaucggugu     1260

cacgccgcaa acccuaaugg gcgauauuac uggggcggac aguacacgug ggacauggcu     1320

aagcauggca cugaugacgg gguggucugg augaacugga aaggauccug guauucaaug     1380

cgcaagauga guaugaaaau aagaccauuc uuuccccaac aguga                     1425


<210>  8526
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__BAG64745

<400>  8526
augaagagaa uggugagcug gagcuuccac aagcugaaga ccaugaagca ccugcugcug       60

cugcugcugu gcguguuccu ggugaagagc cagggcguga acgacaacga ggagggcuuc      120

uucagcgcca gaggccacag accccuggac aagaagagag aggaggccag acccgccaag      180

gccgccgcca cccagaagaa gguggagaga aaggcccccg acgccggcgg cugccugcac      240

gccgaccccg accugggcgu gcugugcccc accggcugcc agcugcagga ggcccugcug      300

cagcaggaga gacccaucag aaacagcgug gacgagcuga acaacaacgu ggaggccgug      360

agccagacca gcagcagcag cuuccaguac auguaccugc ugaaggaccu guggcagaag      420

agacagaagc aggugaagga caacgagaac guggugaacg aguacagcag cgagcuggag      480

aagcaccagc uguacaucga cgagaccgug aacagcaaca uccccaccaa ccugagagug      540

cugagaagca uccuggagaa ccugagaagc aagauccaga agcuggagag cgacgugagc      600

gcccagaugg aguacugcag aacccccugc accgugagcu gcaacauccc cguggugagc      660

ggcaaggagu gcgaggagau caucagaaag ggcggcgaga ccagcgagau guaccugauc      720

cagcccgaca gcagcgugaa gcccuacaga guguacugcg acaugaacac cgagaacggc      780

ggcuggaccg ugauccagaa cagacaggac ggcagcgugg acuucggcag aaagugggac      840

cccuacaagc agggcuucgg caacguggcc accaacaccg acggcaagaa cuacugcggc      900

cugcccggcg aguacuggcu gggcaacgac aagaucagcc agcugaccag aaugggcccc      960

accgagcugc ugaucgagau ggaggacugg aagggcgaca aggugaaggc ccacuacggc     1020

ggcuucaccg ugcagaacga ggccaacaag uaccagauca gcgugaacaa guacagaggc     1080

accgccggca acgcccugau ggacggcgcc agccagcuga ugggcgagaa cagaaccaug     1140

accauccaca acggcauguu cuucagcacc uacgacagag acaacgacgg cuggcugacc     1200

agcgacccca gaaagcagug cagcaaggag gacggcggcg gcugguggua caacagaugc     1260

cacgccgcca accccaacgg cagauacuac uggggcggcc aguacaccug ggacauggcc     1320

aagcacggca ccgacgacgg cguggugugg augaacugga agggcagcug guacagcaug     1380

agaaagauga gcaugaagau cagacccuuc uucccccagc aguga                     1425


<210>  8527
<211>  1425
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__BAG64745

<400>  8527
augaagagaa uggugagcug guccuuccac aaacugaaga ccaugaaaca ucuccugcuu       60

cugcuccugu gcgucuuucu uguuaagucu cagggcguga acgacaauga ggaaggguuc      120

uuuagcgccc ggggacaccg cccccuggau aaaaagagag aggaagcucg gccugccaag      180

gcggcugcca cacagaaaaa gguggagcgc aaagccccgg acgcuggcgg gugucuccau      240

gccgaucccg accugggagu ccugugcccu acgggcuguc aacuccagga agcucugcuu      300

cagcaagaga gacccauccg gaacuccgug gaugagcuga auaacaaugu ugaagccgug      360

ucucagacca gcuccucuag cuuccaguac auguaucucc ugaaggaccu uuggcagaaa      420

cgccaaaagc aggucaagga uaacgagaau gugguuaacg aauacuccag cgagcuggag      480

aaacaccagc ucuauauuga cgaaacaguc aauucuaaca ucccuaccaa ucugagagug      540

cugcggucca uucucgagaa ccugcgcagc aagauccaga aacuugaauc ugaugugucc      600

gcgcaaaugg aguacugcag aacacccugu accgugagcu gcaauauucc ugucguuucu      660

gggaaggaau gugaggagau cauccggaaa ggaggcgaaa cauccgagau guaucugauu      720

cagccggaca gcuccgugaa gcccuaccgc guguauugcg auaugaacac cgaaaauggc      780

ggguggacgg ucauccagaa cagacaagac ggaucugugg auuuuggccg gaaaugggac      840

ccuuacaagc agggguucgg aaacguugcc accaauacag acggcaagaa cuacuguggg      900

cuccccggag aguauuggcu gggcaaugau aaaauuagcc agcuuacccg caugggcccu      960

acagaacugc ucaucgagau ggaggacugg aagggggaua aagugaaggc ucauuacgga     1020

ggcuuuaccg uccagaacga agccaauaaa uaucaaauuu ccgugaacaa guacagaggg     1080

acggcuggaa augcccugau ggacggcgcg agccagcuga ugggggagaa ccggacaaug     1140

accauccaca auggaauguu cuuuucuaca uaugauagag acaacgaugg cuggcucacc     1200

uccgaccccc gcaagcagug cagcaaagaa gauggcgggg gaugguggua caaucggugu     1260

cacgccgcua acccgaaugg cagauauuac uggggagggc aguacaccug ggacauggcc     1320

aagcauggca cagaugacgg gguugugugg augaacugga aaggcucuug guauagcaug     1380

cgcaagaugu ccaugaaaau ucggccuuuc uuuccccaac aguga                     1425


<210>  8528
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__D3DP13

<400>  8528

Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys Gln Val Lys 
1               5                   10                  15      


Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu Glu Lys His 
            20                  25                  30          


Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro Thr Asn Leu 
        35                  40                  45              


Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys Ile Gln Lys 
    50                  55                  60                  


Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg Thr Pro Cys 
65                  70                  75                  80  


Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu Cys Glu Glu 
                85                  90                  95      


Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu Ile Gln Pro 
            100                 105                 110         


Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met Asn Thr Glu 
        115                 120                 125             


Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly Ser Val Asp 
    130                 135                 140                 


Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly Asn Val Ala 
145                 150                 155                 160 


Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly Glu Tyr Trp 
                165                 170                 175     


Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly Pro Thr Glu 
            180                 185                 190         


Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val Lys Ala His 
        195                 200                 205             


Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr Gln Ile Ser 
    210                 215                 220                 


Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met Asp Gly Ala 
225                 230                 235                 240 


Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His Asn Gly Met 
                245                 250                 255     


Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu Thr Ser Asp 
            260                 265                 270         


Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp Trp Tyr Asn 
        275                 280                 285             


Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp Gly Gly Gln 
    290                 295                 300                 


Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly Val Val Trp 
305                 310                 315                 320 


Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met Ser Met Lys 
                325                 330                 335     


Ile Arg Pro Phe Phe Pro Gln Gln 
            340                 


<210>  8529
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__EAX04934

<400>  8529
auguauuugc ugaaagaccu guggcaaaag aggcagaagc aaguaaaaga uaaugaaaau       60

guagucaaug aguacuccuc agaacuggaa aagcaccaau uauauauaga ugagacugug      120

aauagcaaua ucccaacuaa ccuucgugug cuucguucaa uccuggaaaa ccugagaagc      180

aaaauacaaa aguuagaauc ugaugucuca gcucaaaugg aauauugucg caccccaugc      240

acugucaguu gcaauauucc uguggugucu ggcaaagaau gugaggaaau uaucaggaaa      300

ggaggugaaa caucugaaau guaucucauu caaccugaca guucugucaa accguauaga      360

guauacugug acaugaauac agaaaaugga ggauggacag ugauucagaa ccgucaagac      420

gguaguguug acuuuggcag gaaaugggau ccauauaaac agggauuugg aaauguugca      480

accaacacag augggaagaa uuacuguggc cuaccaggug aauauuggcu uggaaaugau      540

aaaauuagcc agcuuaccag gaugggaccc acagaacuuu ugauagaaau ggaggacugg      600

aaaggagaca aaguaaaggc ucacuaugga ggauucacug uacagaauga agccaacaaa      660

uaccagaucu cagugaacaa auacagagga acagccggua augcccucau ggauggagca      720

ucucagcuga ugggagaaaa caggaccaug accauucaca acggcauguu cuucagcacg      780

uaugacagag acaaugacgg cugguuaaca ucagauccca gaaaacagug uucuaaagaa      840

gacgguggug gaugguggua uaauagaugu caugcagcca auccaaacgg cagauacuac      900

ugggguggac aguacaccug ggacauggca aagcauggca cagaugaugg uguaguaugg      960

augaauugga aggggucaug guacucaaug aggaagauga guaugaagau caggcccuuc     1020

uucccacagc aauag                                                      1035


<210>  8530
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__EAX04934

<400>  8530
auguaccugc ucaaggaccu guggcagaag cgccagaagc aggucaagga caacgagaac       60

guggugaacg aguacagcuc cgagcuggag aagcaccagc ucuacaucga cgagaccgug      120

aacagcaaca uccccaccaa ccugcggguc cugcgcucca uccucgagaa ccugcggagc      180

aagauccaga agcuggaguc cgacgugagc gcccagaugg aguacugccg cacgccgugc      240

accguguccu gcaacauccc cgucgugagc ggcaaggagu gcgaggagau cauccggaag      300

ggcggggaga ccuccgagau guaccucauc cagcccgaca gcuccgugaa gcccuaccgc      360

gucuacugcg acaugaacac cgagaacggg ggcuggacgg ugauccagaa ccggcaggac      420

gggagcgugg acuucggccg caagugggac ccguacaagc agggcuucgg gaacgucgcc      480

accaacaccg acggcaagaa cuacugcggg cugcccggcg aguacuggcu ggggaacgac      540

aagaucuccc agcucacccg gaugggcccc acggagcugc ugaucgagau ggaggacugg      600

aagggcgaca aggugaaggc gcacuacggg ggcuucaccg ugcagaacga ggccaacaag      660

uaccagauca gcgucaacaa guaccgcggg accgccggca acgcccucau ggacggcgcc      720

ucccagcuga ugggggagaa ccggaccaug acgauccaca acggcauguu cuucagcacc      780

uacgaccgcg acaacgacgg guggcugacc uccgaccccc ggaagcagug cagcaaggag      840

gacggcgggg gcugguggua caaccgcugc cacgcggcca acccgaacgg ccgguacuac      900

uggggcgggc aguacaccug ggacauggcc aagcacggga cggacgacgg cguggugugg      960

augaacugga agggguccug guacagcaug cgcaagauga gcaugaagau ccggcccuuc     1020

uucccccagc aguga                                                      1035


<210>  8531
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__EAX04934

<400>  8531
auguaccucc ucaaggaccu cuggcagaag cgccagaagc aggucaagga caacgagaac       60

gucgucaacg aguacuccuc cgagcucgag aagcaccagc ucuacaucga cgagaccguc      120

aacuccaaca uccccaccaa ccuccgcguc cuccgcucca uccucgagaa ccuccgcucc      180

aagauccaga agcucgaguc cgacgucucc gcccagaugg aguacugccg cacccccugc      240

accgucuccu gcaacauccc cgucgucucc ggcaaggagu gcgaggagau cauccgcaag      300

ggcggcgaga ccuccgagau guaccucauc cagcccgacu ccuccgucaa gcccuaccgc      360

gucuacugcg acaugaacac cgagaacggc ggcuggaccg ucauccagaa ccgccaggac      420

ggcuccgucg acuucggccg caagugggac cccuacaagc agggcuucgg caacgucgcc      480

accaacaccg acggcaagaa cuacugcggc cuccccggcg aguacuggcu cggcaacgac      540

aagaucuccc agcucacccg caugggcccc accgagcucc ucaucgagau ggaggacugg      600

aagggcgaca aggucaaggc ccacuacggc ggcuucaccg uccagaacga ggccaacaag      660

uaccagaucu ccgucaacaa guaccgcggc accgccggca acgcccucau ggacggcgcc      720

ucccagcuca ugggcgagaa ccgcaccaug accauccaca acggcauguu cuucuccacc      780

uacgaccgcg acaacgacgg cuggcucacc uccgaccccc gcaagcagug cuccaaggag      840

gacggcggcg gcugguggua caaccgcugc cacgccgcca accccaacgg ccgcuacuac      900

uggggcggcc aguacaccug ggacauggcc aagcacggca ccgacgacgg cgucgucugg      960

augaacugga agggcuccug guacuccaug cgcaagaugu ccaugaagau ccgccccuuc     1020

uucccccagc aguga                                                      1035


<210>  8532
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__EAX04934

<400>  8532
auguaccugc ucaaggaccu uuggcagaaa agacaaaaac aggugaagga uaacgagaau       60

gucguuaacg aauauagcuc cgagcuggaa aagcaccagu uguacaucga cgagaccgua      120

aauucuaaca uucccacaaa uuuaagggug cugcggucaa uacuagaaaa ccuccgcagu      180

aaaauccaga agcuggagag cgaugugucc gcccaaaugg aguauugccg aacuccuugu      240

acggucucuu gcaauauucc agugguuucg ggcaaggaau gugaggaaau cauucguaaa      300

gggggagaga ccucagagau guaccuuauc cagccggaca gcagugugaa gcccuauaga      360

gucuacugcg auaugaacac agaaaauggu ggcuggacug ugauacagaa caggcaggac      420

ggguccguag auuucggacg gaaaugggac ccuuauaagc aaggcuuugg uaauguugcu      480

accaacacag augggaaaaa uuacugugga cugccaggcg aguacugguu gggcaacgac      540

aagaucucuc agcucacccg cauggggccc acugaacugc ugauugagau ggaagauugg      600

aagggagaca aagugaaggc acauuauggu ggcuucacag uccagaauga ggccaacaaa      660

uaccagauca gcgugaacaa guauagaggg accgcgggaa augcucucau ggauggcgcc      720

ucccaauuaa ugggugagaa caggacgaug acuauucaca augggauguu uuucucaacc      780

uacgaccggg acaacgaugg auggcugaca agugacccuc gcaaacagug cagcaaggaa      840

gauggcggcg ggugguggua uaaucgaugu caugcagcca acccaaaugg aagauacuau      900

ugggguggcc aguacacuug ggacauggcu aaacacggga ccgaugacgg aguggucugg      960

augaacugga agggcucuug guacuccaug aggaagaugu caaugaaaau ccggcccuuu     1020

uucccucaac aguga                                                      1035


<210>  8533
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__EAX04934

<400>  8533
auguaccugc ugaaggaccu guggcagaag agacagaagc aggugaagga caacgagaac       60

guggugaacg aguacagcag cgagcuggag aagcaccagc uguacaucga cgagaccgug      120

aacagcaaca uccccaccaa ccugagagug cugagaagca uccuggagaa ccugagaagc      180

aagauccaga agcuggagag cgacgugagc gcccagaugg aguacugcag aacccccugc      240

accgugagcu gcaacauccc cguggugagc ggcaaggagu gcgaggagau caucagaaag      300

ggcggcgaga ccagcgagau guaccugauc cagcccgaca gcagcgugaa gcccuacaga      360

guguacugcg acaugaacac cgagaacggc ggcuggaccg ugauccagaa cagacaggac      420

ggcagcgugg acuucggcag aaagugggac cccuacaagc agggcuucgg caacguggcc      480

accaacaccg acggcaagaa cuacugcggc cugcccggcg aguacuggcu gggcaacgac      540

aagaucagcc agcugaccag aaugggcccc accgagcugc ugaucgagau ggaggacugg      600

aagggcgaca aggugaaggc ccacuacggc ggcuucaccg ugcagaacga ggccaacaag      660

uaccagauca gcgugaacaa guacagaggc accgccggca acgcccugau ggacggcgcc      720

agccagcuga ugggcgagaa cagaaccaug accauccaca acggcauguu cuucagcacc      780

uacgacagag acaacgacgg cuggcugacc agcgacccca gaaagcagug cagcaaggag      840

gacggcggcg gcugguggua caacagaugc cacgccgcca accccaacgg cagauacuac      900

uggggcggcc aguacaccug ggacauggcc aagcacggca ccgacgacgg cguggugugg      960

augaacugga agggcagcug guacagcaug agaaagauga gcaugaagau cagacccuuc     1020

uucccccagc aguga                                                      1035


<210>  8534
<211>  1035
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__EAX04934

<400>  8534
auguaccugc ucaaggaccu guggcagaaa agacaaaaac aggugaagga uaacgagaau       60

gucguuaacg aauauagcuc cgagcuugaa aagcaccagc uguacaucga cgagaccguc      120

aauucuaaca uucccacaaa ucuccgggug cugcgcagca uccuugaaaa ccugagaucc      180

aaaauucaga agcucgaguc ugaugugagc gcccaaaugg aguauugccg gacgccuugu      240

accguguccu gcaauauccc gguugugucu ggcaaggaau gugaggaaau uauccgcaaa      300

gggggagaga caagcgagau guaccugauc cagcccgacu ccagcgucaa gccuuauaga      360

guguacugcg auaugaacac cgaaaauggc ggguggacag uuauucagaa ccggcaggac      420

ggaucugugg auuucggccg caaaugggac cccuauaagc aaggguuugg aaaugucgcu      480

accaacacag auggcaaaaa uuacuguggc cugccugggg aguacuggcu cggaaacgac      540

aagaucuccc agcugaccag aaugggcccc acggaacuuc ugauugagau ggaagauugg      600

aagggggaca aagugaaggc ccauuaugga ggcuucaccg ugcagaauga ggcgaacaaa      660

uaccagauca gcgucaacaa guaucggggg acagcuggaa augcccucau ggauggcgcc      720

ucucaacuga ugggcgagaa ccgcaccaug acaauucaca augggauguu uuucuccacc      780

uacgacagag acaacgaugg auggcuuacg agcgacccuc ggaaacagug cucuaaggaa      840

gauggcgggg gaugguggua uaaucgcugu caugcugcca acccgaaugg cagauacuau      900

uggggagggc aguacacaug ggacauggcu aaacacggca ccgaugacgg cguugugugg      960

augaacugga agggguccug guacagcaug cggaagaugu ccaugaaaau ccgccccuuu     1020

uucccucaac aguga                                                      1035


<210>  8535
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__D3DP16

<400>  8535

Met Ile Asp Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile 
1               5                   10                  15      


Met Lys Tyr Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr 
            20                  25                  30          


Leu Gln Glu Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys 
        35                  40                  45              


Glu Lys Val Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp 
    50                  55                  60                  


Thr Val Gln Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala 
65                  70                  75                  80  


Asn Lys Gly Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys 
                85                  90                  95      


Ala Asn Gln Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn 
            100                 105                 110         


Gly Trp Thr Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys 
        115                 120                 125             


Lys Asn Trp Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr 
    130                 135                 140                 


Gly Thr Thr Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser 
145                 150                 155                 160 


Thr Gln Ser Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp 
                165                 170                 175     


Asn Gly Arg Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro 
            180                 185                 190         


Glu Ala Asp Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp 
        195                 200                 205             


Ala Gly Asp Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp 
    210                 215                 220                 


Lys Phe Phe Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn 
225                 230                 235                 240 


Asp Asn Asp Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly 
                245                 250                 255     


Trp Trp Met Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr 
            260                 265                 270         


Gln Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn 
        275                 280                 285             


Gly Ile Ile Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys 
    290                 295                 300                 


Thr Thr Met Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly 
305                 310                 315                 320 


Gln Gln His His Leu Gly Gly Ala Lys Gln Ala Gly Asp Val 
                325                 330                 


<210>  8536
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__EAX04905

<400>  8536
augauagacg cugcuacuuu gaaguccagg aaaauguuag aagaaauuau gaaauaugaa       60

gcaucgauuu uaacacauga cucaaguauu cgauauuugc aggaaauaua uaauucaaau      120

aaucaaaaga uuguuaaccu gaaagagaag guagcccagc uugaagcaca gugccaggaa      180

ccuugcaaag acacggugca aauccaugau aucacuggga aagauuguca agacauugcc      240

aauaagggag cuaaacagag cgggcuuuac uuuauuaaac cucugaaagc uaaccagcaa      300

uucuuagucu acugugaaau cgaugggucu ggaaauggau ggacuguguu ucagaagaga      360

cuugauggca guguagauuu caagaaaaac uggauucaau auaaagaagg auuuggacau      420

cugucuccua cuggcacaac agaauuuugg cugggaaaug agaagauuca uuugauaagc      480

acacagucug ccaucccaua ugcauuaaga guggaacugg aagacuggaa uggcagaacc      540

aguacugcag acuaugccau guucaaggug ggaccugaag cugacaagua ccgccuaaca      600

uaugccuacu ucgcuggugg ggaugcugga gaugccuuug auggcuuuga uuuuggcgau      660

gauccuagug acaaguuuuu cacaucccau aauggcaugc aguucaguac cugggacaau      720

gacaaugaua aguuugaagg caacugugcu gaacaggaug gaucugguug guggaugaac      780

aagugucacg cuggccaucu caauggaguu uauuaccaag guggcacuua cucaaaagca      840

ucuacuccua augguuauga uaauggcauu auuugggcca cuuggaaaac ccggugguau      900

uccaugaaga aaaccacuau gaagauaauc ccauucaaca gacucacaau uggagaagga      960

cagcaacacc accugggggg agccaaacag gcuggagacg uuuaa                     1005


<210>  8537
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__EAX04905

<400>  8537
augaucgacg ccgccacccu caagagccgc aagaugcugg aggagaucau gaaguacgag       60

gcguccaucc ugacccacga cagcuccauc cgguaccugc aggagaucua caacagcaac      120

aaccagaaga ucgugaaccu caaggagaag gucgcccagc uggaggccca gugccaggag      180

cccugcaagg acacggugca gauccacgac aucaccggca aggacugcca ggacaucgcc      240

aacaaggggg ccaagcaguc cggccuguac uucaucaagc cgcucaaggc gaaccagcag      300

uuccuggugu acugcgagau cgacgggagc ggcaacgggu ggaccgucuu ccagaagcgc      360

cuggacggcu ccguggacuu caagaagaac uggauccagu acaaggaggg cuucgggcac      420

cucagcccca ccggcacgac cgaguucugg cuggggaacg agaagaucca ccugaucucc      480

acccagagcg ccauccccua cgcccuccgg guggagcugg aggacuggaa cggccgcacc      540

uccacggccg acuacgcgau guucaagguc gggcccgagg ccgacaagua ccggcugacc      600

uacgccuacu ucgccggcgg cgacgccggg gacgcguucg acggcuucga cuucggggac      660

gacccgagcg acaaguucuu caccucccac aacggcaugc aguucagcac cugggacaac      720

gacaacgaca aguucgaggg caacugcgcc gagcaggacg gguccggcug guggaugaac      780

aagugccacg ccgggcaccu caacggcgug uacuaccagg gcgggacgua cagcaaggcc      840

uccaccccca acggcuacga caacgggauc aucugggcca ccuggaagac ccgcugguac      900

agcaugaaga agacgaccau gaagaucauc cccuucaacc ggcugaccau cggcgagggg      960

cagcagcacc accugggcgg ggcgaagcag gccggcgacg uguga                     1005


<210>  8538
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__EAX04905

<400>  8538
augaucgacg ccgccacccu caagucccgc aagaugcucg aggagaucau gaaguacgag       60

gccuccaucc ucacccacga cuccuccauc cgcuaccucc aggagaucua caacuccaac      120

aaccagaaga ucgucaaccu caaggagaag gucgcccagc ucgaggccca gugccaggag      180

cccugcaagg acaccgucca gauccacgac aucaccggca aggacugcca ggacaucgcc      240

aacaagggcg ccaagcaguc cggccucuac uucaucaagc cccucaaggc caaccagcag      300

uuccucgucu acugcgagau cgacggcucc ggcaacggcu ggaccgucuu ccagaagcgc      360

cucgacggcu ccgucgacuu caagaagaac uggauccagu acaaggaggg cuucggccac      420

cucuccccca ccggcaccac cgaguucugg cucggcaacg agaagaucca ccucaucucc      480

acccaguccg ccauccccua cgcccuccgc gucgagcucg aggacuggaa cggccgcacc      540

uccaccgccg acuacgccau guucaagguc ggccccgagg ccgacaagua ccgccucacc      600

uacgccuacu ucgccggcgg cgacgccggc gacgccuucg acggcuucga cuucggcgac      660

gaccccuccg acaaguucuu caccucccac aacggcaugc aguucuccac cugggacaac      720

gacaacgaca aguucgaggg caacugcgcc gagcaggacg gcuccggcug guggaugaac      780

aagugccacg ccggccaccu caacggcguc uacuaccagg gcggcaccua cuccaaggcc      840

uccaccccca acggcuacga caacggcauc aucugggcca ccuggaagac ccgcugguac      900

uccaugaaga agaccaccau gaagaucauc cccuucaacc gccucaccau cggcgagggc      960

cagcagcacc accucggcgg cgccaagcag gccggcgacg ucuga                     1005


<210>  8539
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__EAX04905

<400>  8539
augaucgacg ccgcuacccu gaaaagcaga aaaaugcucg aggaaauuau gaaguacgag       60

gcauccauac uuacacacga uucuucaauc agguaucugc aggaaauuua caacaguaau      120

aaccaaaaga ucgugaauuu gaaggagaaa gucgcccagu uagaagcgca gugccaggag      180

cccuguaagg acacuguuca aauucaugau aucacgggca aggacugcca ggauauagcu      240

aacaaagggg ccaagcagag cggacuguau uucaucaaac cucuaaaggc aaaucagcaa      300

uuucucgugu acugugagau ugacgguucc ggcaacgggu ggaccguauu ccagaaacgg      360

cuggauggau cuguggacuu uaagaagaau uggauccagu auaaagaagg cuucggucac      420

cuuucgccaa cagggacuac cgaguuuugg cugggaaacg aaaagauuca uuugaucuca      480

acacagagcg ccauaccgua cgcucuccgc gucgagcugg aggauuggaa uggccgaacc      540

aguacugcag acuaugccau guucaaagug ggccccgaag cugauaagua ccgucugaca      600

uacgccuauu uugcaggggg agacgcgggu gaugccuucg acggcuuuga cuucggggau      660

gacccuuccg auaaauuuuu caccucucac aacggaaugc aauuuagcac gugggacaau      720

gauaacgaca aguucgaggg caauugcgcu gaacaggaug guuccgggug guggaugaac      780

aaaugucaug ccggacaccu caauggcguu uacuaucagg gcgggacuua cucaaaggca      840

aguaccccaa acggauauga caacgguauu aucugggcua cauggaagac uagaugguac      900

agcaugaaaa agaccacaau gaaaauuauc cccuucaaua gguuaaccau cggcgagggg      960

caacagcacc aucugggagg cgccaagcag gcgggugaug uguga                     1005


<210>  8540
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__EAX04905

<400>  8540
augaucgacg ccgccacccu gaagagcaga aagaugcugg aggagaucau gaaguacgag       60

gccagcaucc ugacccacga cagcagcauc agauaccugc aggagaucua caacagcaac      120

aaccagaaga ucgugaaccu gaaggagaag guggcccagc uggaggccca gugccaggag      180

cccugcaagg acaccgugca gauccacgac aucaccggca aggacugcca ggacaucgcc      240

aacaagggcg ccaagcagag cggccuguac uucaucaagc cccugaaggc caaccagcag      300

uuccuggugu acugcgagau cgacggcagc ggcaacggcu ggaccguguu ccagaagaga      360

cuggacggca gcguggacuu caagaagaac uggauccagu acaaggaggg cuucggccac      420

cugagcccca ccggcaccac cgaguucugg cugggcaacg agaagaucca ccugaucagc      480

acccagagcg ccauccccua cgcccugaga guggagcugg aggacuggaa cggcagaacc      540

agcaccgccg acuacgccau guucaaggug ggccccgagg ccgacaagua cagacugacc      600

uacgccuacu ucgccggcgg cgacgccggc gacgccuucg acggcuucga cuucggcgac      660

gaccccagcg acaaguucuu caccagccac aacggcaugc aguucagcac cugggacaac      720

gacaacgaca aguucgaggg caacugcgcc gagcaggacg gcagcggcug guggaugaac      780

aagugccacg ccggccaccu gaacggcgug uacuaccagg gcggcaccua cagcaaggcc      840

agcaccccca acggcuacga caacggcauc aucugggcca ccuggaagac cagaugguac      900

agcaugaaga agaccaccau gaagaucauc cccuucaaca gacugaccau cggcgagggc      960

cagcagcacc accugggcgg cgccaagcag gccggcgacg uguga                     1005


<210>  8541
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__EAX04905

<400>  8541
augaucgacg ccgcuacccu caagagcaga aaaaugcugg aggaaauuau gaaguacgag       60

gccuccaucc ugacacacga uucuagcauu cgguaucuuc aggaaaucua caacuccaau      120

aaccagaaaa uugugaaucu gaaggagaaa gucgcgcagc ucgaagcuca gugccaggag      180

cccuguaagg acacgguuca aauccaugau aucaccggca aggacugcca ggauauugcc      240

aacaaagggg ccaagcaguc uggacuguau uucaucaaac cucuuaaggc uaaucagcaa      300

uuucuggugu acugugagau ugacggcagc gggaacggau ggacaguguu ccagaaacgc      360

cucgauggcu ccgucgacuu uaagaagaau uggauccagu auaaagaagg guucggacac      420

cugucuccga ccggcacaac cgaguuuugg cugggcaacg aaaagauuca ucucaucagc      480

acacaguccg ccauucccua cgcucugaga guggagcuug aggauuggaa ugggcggacc      540

agcacggccg acuaugcgau guucaaaguu ggaccugaag ccgauaagua ccgccugacc      600

uacgcuuauu uugccggcgg ggacgcugga gaugccuucg acggcuuuga cuucggggau      660

gaccccucug auaaauuuuu cacaucccac aacggaaugc aauuuagcac cugggacaau      720

gauaacgaca aguucgaggg caauugcgcg gaacaggaug gcucugggug guggaugaac      780

aaaugucaug ccggacaccu caauggcgug uacuaucaag ggggaacaua cuccaaggcu      840

agcaccccua acggcuauga caacgggauc aucugggcca cguggaagac aagaugguac      900

ucuaugaaaa agaccacaau gaaaauuauc cccuucaauc ggcugaccau uggagagggc      960

caacagcacc aucuuggcgg ggcuaagcag gccggagaug ucuga                     1005


<210>  8542
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__D3DSP9

<400>  8542

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Ile Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr 
            20                  25                  30          


Lys Leu Ser Gly Phe Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu 
        35                  40                  45              


Phe Ser Val Tyr Cys Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile 
    50                  55                  60                  


Gln Arg Arg Ser Asp Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp 
65                  70                  75                  80  


Tyr Glu Asn Gly Phe Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp 
                85                  90                  95      


Leu Gly Asn Lys Asn Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr 
            100                 105                 110         


Leu Lys Ile Asp Leu Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln 
        115                 120                 125             


Tyr Lys Asn Phe Lys Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn 
    130                 135                 140                 


Ile Gly Glu Tyr Ser Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe 
145                 150                 155                 160 


His Pro Glu Val Gln Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser 
                165                 170                 175     


Thr Trp Asp Arg Asp His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu 
            180                 185                 190         


Asp Gln Ser Gly Trp Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn 
        195                 200                 205             


Gly Val Tyr Tyr Ser Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile 
    210                 215                 220                 


Val Trp Tyr Thr Trp His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val 
225                 230                 235                 240 


Met Lys Ile Arg Pro Asn Asp Phe Ile Pro Asn Val Ile 
                245                 250             


<210>  8543
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__EAW63802

<400>  8543
auggcaaagg uguucaguuu cauccuuguu accaccgcuc ugauaauggg cagggaaauu       60

ucggcagauu guucagagau uuucaaugau ggguauaagc ucaguggauu uuacaaaauc      120

aaaccucucc agagcccagc agaauuuucu guuuauugug acauguccga uggaggagga      180

uggacuguaa uucagagacg aucugauggc agugaaaacu uuaacagagg auggaaagac      240

uaugaaaaug gcuuuggaaa uuuuguccaa aaacauggug aauauuggcu gggcaauaaa      300

aaucuucacu ucuugaccac ucaagaagac uacacuuuaa aaaucgaccu ugcagauuuu      360

gaaaaaaaua gccguuaugc acaauauaag aauuucaaag uuggagauga aaagaauuuc      420

uacgaguuga auauugggga auauucugga acagcuggag auucccuugc ggggaauuuu      480

cauccugagg ugcaguggug ggcuagucac caaagaauga aauucagcac gugggacaga      540

gaucaugaca acuaugaagg gaacugcgca gaagaagauc agucuggcug gugguuuaac      600

aggugucacu cugcaaaccu gaauggugua uacuacagcg gccccuacac ggcuaaaaca      660

gacaauggga uugucuggua caccuggcau gggugguggu auucucugaa aucugugguu      720

augaaaauua ggccaaauga uuuuauucca aauguaauuu aa                         762


<210>  8544
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__EAW63802

<400>  8544
auggccaagg uguucagcuu cauccugguc accaccgccc ugaucauggg ccgcgagauc       60

uccgcggacu gcagcgagau cuucaacgac ggguacaagc uguccggcuu cuacaagauc      120

aagccccugc agagcccggc cgaguucucc guguacugcg acaugagcga cgggggcggg      180

uggacgguga uccagcggcg cuccgacggc agcgagaacu ucaaccgggg cuggaaggac      240

uacgagaacg gguucggcaa cuucguccag aagcacgggg aguacuggcu cggcaacaag      300

aaccugcacu uccugaccac ccaggaggac uacacccuca agaucgaccu ggccgacuuc      360

gagaagaacu cccgcuacgc ccaguacaag aacuucaagg ugggggacga gaagaacuuc      420

uacgagcuga acaucggcga guacagcggc acggccgggg acucccucgc gggcaacuuc      480

caccccgagg ugcaguggug ggccagccac cagcggauga aguucuccac cugggaccgc      540

gaccacgaca acuacgaggg gaacugcgcc gaggaggacc agagcggcug gugguucaac      600

cggugccacu ccgccaaccu gaacggcguc uacuacagcg ggcccuacac cgcgaagacc      660

gacaacggca ucguguggua cacguggcac gggugguggu acucccucaa gagcgugguc      720

augaagaucc gccccaacga cuucaucccg aacgugaucu ga                         762


<210>  8545
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__EAW63802

<400>  8545
auggccaagg ucuucuccuu cauccucguc accaccgccc ucaucauggg ccgcgagauc       60

uccgccgacu gcuccgagau cuucaacgac ggcuacaagc ucuccggcuu cuacaagauc      120

aagccccucc agucccccgc cgaguucucc gucuacugcg acauguccga cggcggcggc      180

uggaccguca uccagcgccg cuccgacggc uccgagaacu ucaaccgcgg cuggaaggac      240

uacgagaacg gcuucggcaa cuucguccag aagcacggcg aguacuggcu cggcaacaag      300

aaccuccacu uccucaccac ccaggaggac uacacccuca agaucgaccu cgccgacuuc      360

gagaagaacu cccgcuacgc ccaguacaag aacuucaagg ucggcgacga gaagaacuuc      420

uacgagcuca acaucggcga guacuccggc accgccggcg acucccucgc cggcaacuuc      480

caccccgagg uccaguggug ggccucccac cagcgcauga aguucuccac cugggaccgc      540

gaccacgaca acuacgaggg caacugcgcc gaggaggacc aguccggcug gugguucaac      600

cgcugccacu ccgccaaccu caacggcguc uacuacuccg gccccuacac cgccaagacc      660

gacaacggca ucgucuggua caccuggcac ggcugguggu acucccucaa guccgucguc      720

augaagaucc gccccaacga cuucaucccc aacgucaucu ga                         762


<210>  8546
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__EAW63802

<400>  8546
auggccaagg uguucagcuu uauccugguc accacagcuc ucauuauggg cagagagaua       60

uccgcagacu gcucugaaau cuucaacgau ggguacaaac uuucaggauu uuauaagauu      120

aaaccccugc agaguccugc cgaguucagc guuuacugug acauguccga ugguggcggg      180

uggacuguga uccaaaggcg gucugacgga ucggaaaauu uuaaccgcgg cuggaaggau      240

uaugagaaug guuucgggaa cuuuguacag aaacacggag aauacugguu gggcaauaag      300

aacuuacauu uccugacgac ccaggaggac uauacacuaa agauugaucu cgcggacuuu      360

gagaaaaauu cacgauacgc ucaguauaag aacuucaaag ugggcgauga aaagaauuuu      420

uacgagcuga acaucgggga auacagcgga acugccggug acagucuugc aggcaauuuc      480

cacccagagg uccaauggug ggccucccau cagcguauga aauuuucuac cugggauaga      540

gaccacgaua acuaugaggg gaauugcgcu gaagaggacc agagcggaug gugguucaac      600

aggugucauu ccgcaaaucu gaacggcgug uacuauucag guccguacac agccaagacc      660

gacaacggga uaguuuggua uacuuggcac ggaugguggu acaguuugaa aagcgugguc      720

augaagaucc ggcccaauga uuucauuccu aacgugaucu ga                         762


<210>  8547
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__EAW63802

<400>  8547
auggccaagg uguucagcuu cauccuggug accaccgccc ugaucauggg cagagagauc       60

agcgccgacu gcagcgagau cuucaacgac ggcuacaagc ugagcggcuu cuacaagauc      120

aagccccugc agagccccgc cgaguucagc guguacugcg acaugagcga cggcggcggc      180

uggaccguga uccagagaag aagcgacggc agcgagaacu ucaacagagg cuggaaggac      240

uacgagaacg gcuucggcaa cuucgugcag aagcacggcg aguacuggcu gggcaacaag      300

aaccugcacu uccugaccac ccaggaggac uacacccuga agaucgaccu ggccgacuuc      360

gagaagaaca gcagauacgc ccaguacaag aacuucaagg ugggcgacga gaagaacuuc      420

uacgagcuga acaucggcga guacagcggc accgccggcg acagccuggc cggcaacuuc      480

caccccgagg ugcaguggug ggccagccac cagagaauga aguucagcac cugggacaga      540

gaccacgaca acuacgaggg caacugcgcc gaggaggacc agagcggcug gugguucaac      600

agaugccaca gcgccaaccu gaacggcgug uacuacagcg gccccuacac cgccaagacc      660

gacaacggca ucguguggua caccuggcac ggcugguggu acagccugaa gagcguggug      720

augaagauca gacccaacga cuucaucccc aacgugaucu ga                         762


<210>  8548
<211>  762
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__EAW63802

<400>  8548
auggccaagg uguucagcuu uauccugguc accacagcuc ucauuauggg cagagagauc       60

uccgccgacu gcucugaaau uuucaacgau ggguacaaac ugagcggauu uuauaagauc      120

aaaccccuuc aguccccugc ggaguucucu guuuacugug acaugagcga uggcggggga      180

uggacgguga uucaacggcg cuccgacggc ucugaaaauu uuaacagagg guggaaggau      240

uaugagaaug gauucggcaa cuuugugcag aaacacggcg aauacuggcu ggggaauaag      300

aaccuccauu uccugaccac acaggaggac uauacccuua agaucgaucu ggcugacuuu      360

gagaaaaaua gccgguacgc ccaguauaag aacuucaaag ucggagauga aaagaauuuu      420

uacgagcuca acaucggcga auacuccggg acagccggag acagccuggc uggcaauuuc      480

cacccggagg ugcaauggug ggccucucau cagcgcauga aauuuuccac cugggauaga      540

gaccacgaua acuaugaggg gaauugcgcu gaagaggacc agagcggaug gugguucaac      600

cggugucauu cugccaaucu gaacggcguu uacuauuccg gccccuacac agcgaagacc      660

gacaacggga uuguguggua uacguggcac ggaugguggu acagccucaa gucugucgug      720

augaaaaucc gcccuaauga uuucauuccc aacguuaucu ga                         762


<210>  8549
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__P02671

<400>  8549

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  8550
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAA17056

<400>  8550
auguuuucca ugaggaucgu cugccuaguu cuaagugugg ugggcacagc auggacugca       60

gauaguggug aaggugacuu ucuagcugaa ggaggaggcg ugcguggccc aaggguugug      120

gaaagacauc aaucugccug caaagauuca gacuggcccu ucugcucuga ugaagacugg      180

aacuacaaau gcccuucugg cugcaggaug aaaggguuga uugaugaagu caaucaagau      240

uuuacaaaca gaauaaauaa gcucaaaaau ucacuauuug aauaucagaa gaacaauaag      300

gauucucauu cguugaccac uaauauaaug gaaauuuuga gaggcgauuu uuccucagcc      360

aauaaccgug auaauaccua caaccgagug ucagaggauc ugagaagcag aauugaaguc      420

cugaagcgca aagucauaga aaaaguacag cauauccagc uucugcagaa aaauguuaga      480

gcucaguugg uugauaugaa acgacuggag guggacauug auauuaagau ccgaucuugu      540

cgagggucau gcaguagggc uuuagcucgu gaaguagauc ugaaggacua ugaagaucag      600

cagaagcaac uugaacaggu cauugccaaa gacuuacuuc ccucuagaga uaggcaacac      660

uuaccacuga uaaaaaugaa accaguucca gacuugguuc ccggaaauuu uaagagccag      720

cuucagaagg uacccccaga guggaaggca uuaacagaca ugccgcagau gagaauggag      780

uuagagagac cugguggaaa ugagauuacu cgaggaggcu ccaccucuua uggaaccgga      840

ucagagacgg aaagccccag gaacccuagc agugcuggaa gcuggaacuc ugggagcucu      900

ggaccuggaa guacuggaaa ccgaaacccu gggagcucug ggacuggagg gacugcaacc      960

uggaaaccug ggagcucugg accuggaagu acuggaagcu ggaacucugg gagcucugga     1020

acuggaagua cuggaaacca aaacccuggg agcccuagac cugguaguac cggaaccugg     1080

aauccuggca gcucugaacg cggaagugcu gggcacugga ccucugagag cucuguaucu     1140

gguaguacug gacaauggca cucugaaucu ggaaguuuua ggccagauag cccaggcucu     1200

gggaacgcga ggccuaacaa cccagacugg ggcacauuug aagagguguc aggaaaugua     1260

aguccaggga caaggagaga guaccacaca gaaaaacugg ucacuucuaa aggagauaaa     1320

gagcucagga cugguaaaga gaaggucacc ucugguagca caaccaccac gcgucguuca     1380

ugcucuaaaa ccguuacuaa gacuguuauu gguccugaug gucacaaaga aguuaccaaa     1440

gaagugguga ccuccgaaga ugguucugac ugucccgagg caauggauuu aggcacauug     1500

ucuggcauag guacucugga uggguuccgc cauaggcacc cugaugaagc ugccuucuuc     1560

gacacugccu caacuggaaa aacauuccca gguuucuucu caccuauguu aggagaguuu     1620

gucagugaga cugagucuag gggcucagaa ucuggcaucu ucacaaauac aaaggaaucc     1680

aguucucauc acccugggau agcugaauuc ccuucccgug guaaaucuuc aaguuacagc     1740

aaacaauuua cuaguagcac gaguuacaac agaggagacu ccacauuuga aagcaagagc     1800

uauaaaaugg cagaugaggc cggaagugaa gccgaucaug aaggaacaca uagcaccaag     1860

agaggccaug cuaaaucucg cccugucaga gacugugaug auguccucca aacacauccu     1920

ucagguaccc aaaguggcau uuucaauauc aagcuaccgg gauccaguaa gauuuuuucu     1980

guuuauugcg aucaagagac caguuuggga ggauggcuuu ugauccagca aagaauggau     2040

ggaucacuga auuuuaaccg gaccuggcaa gacuacaaga gagguuucgg cagccugaau     2100

gacgaggggg aaggagaauu cuggcuaggc aaugacuacc uccacuuacu aacccaaagg     2160

ggcucuguuc uuaggguuga auuagaggac ugggcuggga augaagcuua ugcagaauau     2220

cacuuccggg uaggcucuga ggcugaaggc uaugcccucc aagucuccuc cuaugaaggc     2280

acugcgggug augcucugau ugaggguucc guagaggaag gggcagagua caccucucac     2340

aacaacaugc aguucagcac cuuugacagg gaugcagacc agugggaaga gaacugugca     2400

gaagucuaug ggggaggcug gugguauaau aacugccaag cagccaaucu caauggaauc     2460

uacuacccug ggggcuccua ugacccaagg aauaacaguc cuuaugagau ugagaaugga     2520

guggucuggg uuuccuuuag aggggcagau uauucccuca gggcuguucg caugaaaauu     2580

aggccccuug ugacccaaua g                                               2601


<210>  8551
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAA17056

<400>  8551
auguucagca ugcgcaucgu gugccugguc cucuccgugg ugggcaccgc cuggaccgcc       60

gacagcgggg agggcgacuu ccuggcggag ggcggcgggg uccgggggcc ccgcguggug      120

gagcggcacc aguccgccug caaggacagc gacuggccgu ucugcuccga cgaggacugg      180

aacuacaagu gccccagcgg cugccgcaug aaggggcuga ucgacgaggu caaccaggac      240

uucacgaacc ggaucaacaa gcucaagaac ucccuguucg aguaccagaa gaacaacaag      300

gacagccacu cccugaccac caacaucaug gagauccucc gcggcgacuu cagcuccgcc      360

aacaaccggg acaacaccua caaccgcgug agcgaggacc ugcggucccg caucgaggug      420

cugaagcgga aggucaucga gaaggugcag cacauccagc uccugcagaa gaacgugcgc      480

gcccagcugg ucgacaugaa gcggcucgag guggacaucg acaucaagau ccgcagcugc      540

cggggguccu gcagccgcgc ccuggcgcgg gagguggacc ugaaggacua cgaggaccag      600

cagaagcagc ucgagcaggu caucgccaag gaccugcugc ccucccgcga ccggcagcac      660

cucccccuga ucaagaugaa gccggugccc gaccuggugc ccggcaacuu caagagccag      720

cuccagaagg ugcccccgga guggaaggcc cugacggaca ugccccagau gcgcauggag      780

cuggagcggc ccgggggcaa cgagaucacc cgcggcgggu ccaccagcua cggcaccggg      840

agcgagacgg agagcccccg caacccgucc uccgccggca gcuggaacuc cggcagcucc      900

gggcccggca gcaccgggaa ccggaacccc ggcuccagcg ggaccggcgg caccgcgacg      960

uggaagcccg gguccagcgg cccggggucc accggcagcu ggaacuccgg gagcuccggc     1020

accggcagca ccgggaacca gaaccccggc agcccccgcc ccggguccac gggcaccugg     1080

aacccgggga gcuccgagcg gggcagcgcc ggccacugga ccuccgagag cuccgucagc     1140

ggguccaccg gccaguggca cagcgagucc gggagcuucc gccccgacuc ccccggcagc     1200

ggcaacgccc ggcccaacaa cccggacugg gggacguucg aggagguguc cggcaacguc     1260

agccccggga cccgccggga guaccacacc gagaagcucg ugaccuccaa gggcgacaag     1320

gagcugcgca cggggaagga gaaggugacc agcggcucca ccaccacgac ccggcgcagc     1380

ugcagcaaga ccgucaccaa gacggugauc ggccccgacg ggcacaagga ggucaccaag     1440

gaggugguga ccuccgagga cggcagcgac ugccccgagg ccauggaccu ggggacccuc     1500

uccggcaucg ggacgcugga cggcuuccgg caccgccacc cggacgaggc cgcguucuuc     1560

gacaccgcca gcaccggcaa gaccuucccc ggguucuucu cccccaugcu gggcgaguuc     1620

gucagcgaga ccgagucccg ggggagcgag uccggcaucu ucacgaacac caaggagagc     1680

uccagccacc acccggggau cgccgaguuc cccucccgcg gcaagagcuc cagcuacucc     1740

aagcaguuca ccagcuccac cagcuacaac cggggcgaca gcacguucga guccaagagc     1800

uacaagaugg ccgacgaggc cggguccgag gcggaccacg agggcaccca cagcaccaag     1860

cgcgggcacg ccaagucccg gcccgugcgc gacugcgacg acgugcucca gacccacccc     1920

agcggcacgc aguccgggau cuucaacauc aagcugccgg gcagcuccaa gaucuucagc     1980

gucuacugcg accaggagac cucccugggc ggguggcucc ugauccagca gcggauggac     2040

ggcagccuga acuucaaccg caccuggcag gacuacaagc gcggguucgg cucccucaac     2100

gacgagggcg agggggaguu cuggcugggc aacgacuacc ugcaccuccu gacccagcgg     2160

gggagcgugc ugcgcgugga gcucgaggac ugggccggca acgaggccua cgccgaguac     2220

cacuuccggg ucggguccga ggcggagggc uacgcccucc aggugagcuc cuacgagggc     2280

acggccgggg acgcccugau cgagggcagc guggaggagg gggccgagua caccucccac     2340

aacaacaugc aguucagcac cuucgaccgc gacgcggacc agugggagga gaacugcgcc     2400

gaggucuacg gcgggggcug gugguacaac aacugccagg ccgccaaccu gaacggcauc     2460

uacuaccccg ggggcagcua cgacccccgg aacaacuccc ccuacgagau cgagaacggg     2520

gugguguggg ucagcuuccg cggcgcggac uacucccugc gggccgugcg caugaagauc     2580

cggccgcugg ugacccagug a                                               2601


<210>  8552
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAA17056

<400>  8552
auguucucca ugcgcaucgu cugccucguc cucuccgucg ucggcaccgc cuggaccgcc       60

gacuccggcg agggcgacuu ccucgccgag ggcggcggcg uccgcggccc ccgcgucguc      120

gagcgccacc aguccgccug caaggacucc gacuggcccu ucugcuccga cgaggacugg      180

aacuacaagu gccccuccgg cugccgcaug aagggccuca ucgacgaggu caaccaggac      240

uucaccaacc gcaucaacaa gcucaagaac ucccucuucg aguaccagaa gaacaacaag      300

gacucccacu cccucaccac caacaucaug gagauccucc gcggcgacuu cuccuccgcc      360

aacaaccgcg acaacaccua caaccgcguc uccgaggacc uccgcucccg caucgagguc      420

cucaagcgca aggucaucga gaagguccag cacauccagc uccuccagaa gaacguccgc      480

gcccagcucg ucgacaugaa gcgccucgag gucgacaucg acaucaagau ccgcuccugc      540

cgcggcuccu gcucccgcgc ccucgcccgc gaggucgacc ucaaggacua cgaggaccag      600

cagaagcagc ucgagcaggu caucgccaag gaccuccucc ccucccgcga ccgccagcac      660

cucccccuca ucaagaugaa gcccgucccc gaccucgucc ccggcaacuu caagucccag      720

cuccagaagg ucccccccga guggaaggcc cucaccgaca ugccccagau gcgcauggag      780

cucgagcgcc ccggcggcaa cgagaucacc cgcggcggcu ccaccuccua cggcaccggc      840

uccgagaccg aguccccccg caaccccucc uccgccggcu ccuggaacuc cggcuccucc      900

ggccccggcu ccaccggcaa ccgcaacccc ggcuccuccg gcaccggcgg caccgccacc      960

uggaagcccg gcuccuccgg ccccggcucc accggcuccu ggaacuccgg cuccuccggc     1020

accggcucca ccggcaacca gaaccccggc uccccccgcc ccggcuccac cggcaccugg     1080

aaccccggcu ccuccgagcg cggcuccgcc ggccacugga ccuccgaguc cuccgucucc     1140

ggcuccaccg gccaguggca cuccgagucc ggcuccuucc gccccgacuc ccccggcucc     1200

ggcaacgccc gccccaacaa ccccgacugg ggcaccuucg aggaggucuc cggcaacguc     1260

ucccccggca cccgccgcga guaccacacc gagaagcucg ucaccuccaa gggcgacaag     1320

gagcuccgca ccggcaagga gaaggucacc uccggcucca ccaccaccac ccgccgcucc     1380

ugcuccaaga ccgucaccaa gaccgucauc ggccccgacg gccacaagga ggucaccaag     1440

gaggucguca ccuccgagga cggcuccgac ugccccgagg ccauggaccu cggcacccuc     1500

uccggcaucg gcacccucga cggcuuccgc caccgccacc ccgacgaggc cgccuucuuc     1560

gacaccgccu ccaccggcaa gaccuucccc ggcuucuucu cccccaugcu cggcgaguuc     1620

gucuccgaga ccgagucccg cggcuccgag uccggcaucu ucaccaacac caaggagucc     1680

uccucccacc accccggcau cgccgaguuc cccucccgcg gcaaguccuc cuccuacucc     1740

aagcaguuca ccuccuccac cuccuacaac cgcggcgacu ccaccuucga guccaagucc     1800

uacaagaugg ccgacgaggc cggcuccgag gccgaccacg agggcaccca cuccaccaag     1860

cgcggccacg ccaagucccg ccccguccgc gacugcgacg acguccucca gacccacccc     1920

uccggcaccc aguccggcau cuucaacauc aagcuccccg gcuccuccaa gaucuucucc     1980

gucuacugcg accaggagac cucccucggc ggcuggcucc ucauccagca gcgcauggac     2040

ggcucccuca acuucaaccg caccuggcag gacuacaagc gcggcuucgg cucccucaac     2100

gacgagggcg agggcgaguu cuggcucggc aacgacuacc uccaccuccu cacccagcgc     2160

ggcuccgucc uccgcgucga gcucgaggac ugggccggca acgaggccua cgccgaguac     2220

cacuuccgcg ucggcuccga ggccgagggc uacgcccucc aggucuccuc cuacgagggc     2280

accgccggcg acgcccucau cgagggcucc gucgaggagg gcgccgagua caccucccac     2340

aacaacaugc aguucuccac cuucgaccgc gacgccgacc agugggagga gaacugcgcc     2400

gaggucuacg gcggcggcug gugguacaac aacugccagg ccgccaaccu caacggcauc     2460

uacuaccccg gcggcuccua cgacccccgc aacaacuccc ccuacgagau cgagaacggc     2520

gucgucuggg ucuccuuccg cggcgccgac uacucccucc gcgccguccg caugaagauc     2580

cgcccccucg ucacccagug a                                               2601


<210>  8553
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAA17056

<400>  8553
auguucagca ugagaaucgu gugccugguc cucuccguug ugggcaccgc cuggacagcu       60

gacucugggg agggagauuu ucuugcagaa gguggcgggg uaaggggacc ccgggugguc      120

gagcgccacc agucagccug uaaggacagu gauuggccuu ucugcagcga cgaagauugg      180

aacuacaaau guccauccgg cugccgaaug aagggucuga uugacgaggu gaaucaagau      240

uuuacuaacc guauaaauaa auugaagaac ucuuuauucg aauaucagaa aaauaacaag      300

gacucgcauu cacugacgac caauaucaug gagauucuaa gaggggauuu uagcagugcg      360

aacaauaggg acaacacaua caaucggguu uccgaggauc uccgcucuag aaucgaagug      420

cugaagagga aagucauuga gaaggugcag cacauccagc uucugcaaaa gaacguacgg      480

gcucaguugg uugacaugaa gcgccucgaa guggauauag acaucaaaau ucgaagcugu      540

agaggauccu gcucaagggc ccuggcacgg gaggucgacc ugaaggauua ugaggaccag      600

cagaagcaac ucgaacaggu gaucgccaaa gauuuacugc cgagucguga ccgccagcau      660

cuucccuuga uuaagaugaa accugugcca gaucuggucc ccggcaauuu caagagccag      720

cuacaaaaag uuccuccaga guggaaggcu cucacugaca ugccccagau gagaauggaa      780

cuggagaggc cuggcgggaa cgaaaucacc cggggagguu cuacauccua cggcaccggg      840

ucagagacug agagcccacg aaauccgagu ucugcaggau ccuggaacag cggcucgucu      900

ggucccgggu ccacaggaaa ccgcaauccu ggcucaagug gcaccggggg aacggccacu      960

uggaaaccag guagcuccgg ccccgggucu accggaagcu ggaacucagg caguuccggu     1020

acagggagca cuggcaauca gaacccugga ucuccaagac ccggcucaac cgggacaugg     1080

aauccgggaa guagcgaaag ggguuccgcu ggccacugga ccucugaguc gagcgugucc     1140

gggucaacgg gacaauggca uagugaaucu ggcagcuuuc ggccugauuc ccccgguuca     1200

gggaacgccc gcccaaauaa cccugacugg ggcacuuucg aggaaguaag cggaaaugug     1260

ucucccggca caagaaggga guaucacacc gagaaacuug ucacuuccaa gggggauaaa     1320

gaacugcgua caggaaagga gaaagugacc agugguagca cgaccacaac ucggcgaucu     1380

uguuccaaga ccguuacaaa aacugugaua ggcccagacg ggcacaagga agucaccaag     1440

gaggugguaa caucagaaga uggaagugac ugccccgagg cgauggacuu gggcacccuc     1500

agcgguauug ggacucugga uggcuuuaga cauaggcacc cugacgaggc agccuucuuu     1560

gauacggcuu cgacaggaaa aaccuuccca ggcuuuuucu ccccgauguu aggggaguuc     1620

guuucugaaa cugaaagccg cggaucagag aguggcaucu uuaccaacac aaaggagucc     1680

ucuagccauc accccgguau ugccgaguuc ccuucccggg ggaaaucaag caguuacucu     1740

aagcaguuua ccuccagcac uucguauaau agaggagacu caacauucga aucuaaaagu     1800

uacaagaugg cagaugaagc uggcuccgag gccgaccacg aagguacgca uagcaccaag     1860

aggggccacg cgaaaucucg cccagugcga gauugugacg auguccugca gacucauccc     1920

agcgggacac aguccggaau cuuuaacauc aagcucccug gcucaaguaa aauuuucagc     1980

guguacugcg accaagagac cucucuuggg ggauggcugu ugauacagca gcggauggau     2040

ggcucccuaa auuuuaaccg uacauggcag gacuauaaga gagguuucgg gucacugaau     2100

gaugagggag aaggcgaguu uuggcucggu aacgacuacc ugcaccuucu gacucaaagg     2160

ggcagugucu ugcgcgugga acucgaggac ugggccggga acgaagcaua ugcugaguac     2220

cauuuccggg uuggaagcga ggccgaaggc uaugcuuuac agguguccuc uuacgagggg     2280

accgccggag augcacugau cgaaggcucg guagaggaag gugccgagua uacgagccac     2340

aauaacaugc aguuuucaac cuucgacaga gaugcugacc agugggagga aaauugugcg     2400

gaggucuacg ggggaggcug gugguacaac aauugccaag cagccaaccu gaaugguauu     2460

uauuacccag gcggguccua ugaucccagg aacaauaguc cguacgaaau cgagaacgga     2520

gugguuuggg ugucuuuucg aggcgcugac uauagccuac gcgccguccg gaugaaaaua     2580

agaccucucg ugacacagug a                                               2601


<210>  8554
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAA17056

<400>  8554
auguucagca ugagaaucgu gugccuggug cugagcgugg ugggcaccgc cuggaccgcc       60

gacagcggcg agggcgacuu ccuggccgag ggcggcggcg ugagaggccc cagaguggug      120

gagagacacc agagcgccug caaggacagc gacuggcccu ucugcagcga cgaggacugg      180

aacuacaagu gccccagcgg cugcagaaug aagggccuga ucgacgaggu gaaccaggac      240

uucaccaaca gaaucaacaa gcugaagaac agccuguucg aguaccagaa gaacaacaag      300

gacagccaca gccugaccac caacaucaug gagauccuga gaggcgacuu cagcagcgcc      360

aacaacagag acaacaccua caacagagug agcgaggacc ugagaagcag aaucgaggug      420

cugaagagaa aggugaucga gaaggugcag cacauccagc ugcugcagaa gaacgugaga      480

gcccagcugg uggacaugaa gagacuggag guggacaucg acaucaagau cagaagcugc      540

agaggcagcu gcagcagagc ccuggccaga gagguggacc ugaaggacua cgaggaccag      600

cagaagcagc uggagcaggu gaucgccaag gaccugcugc ccagcagaga cagacagcac      660

cugccccuga ucaagaugaa gcccgugccc gaccuggugc ccggcaacuu caagagccag      720

cugcagaagg ugccccccga guggaaggcc cugaccgaca ugccccagau gagaauggag      780

cuggagagac ccggcggcaa cgagaucacc agaggcggca gcaccagcua cggcaccggc      840

agcgagaccg agagccccag aaaccccagc agcgccggca gcuggaacag cggcagcagc      900

ggccccggca gcaccggcaa cagaaacccc ggcagcagcg gcaccggcgg caccgccacc      960

uggaagcccg gcagcagcgg ccccggcagc accggcagcu ggaacagcgg cagcagcggc     1020

accggcagca ccggcaacca gaaccccggc agccccagac ccggcagcac cggcaccugg     1080

aaccccggca gcagcgagag aggcagcgcc ggccacugga ccagcgagag cagcgugagc     1140

ggcagcaccg gccaguggca cagcgagagc ggcagcuuca gacccgacag ccccggcagc     1200

ggcaacgcca gacccaacaa ccccgacugg ggcaccuucg aggaggugag cggcaacgug     1260

agccccggca ccagaagaga guaccacacc gagaagcugg ugaccagcaa gggcgacaag     1320

gagcugagaa ccggcaagga gaaggugacc agcggcagca ccaccaccac cagaagaagc     1380

ugcagcaaga ccgugaccaa gaccgugauc ggccccgacg gccacaagga ggugaccaag     1440

gaggugguga ccagcgagga cggcagcgac ugccccgagg ccauggaccu gggcacccug     1500

agcggcaucg gcacccugga cggcuucaga cacagacacc ccgacgaggc cgccuucuuc     1560

gacaccgcca gcaccggcaa gaccuucccc ggcuucuuca gccccaugcu gggcgaguuc     1620

gugagcgaga ccgagagcag aggcagcgag agcggcaucu ucaccaacac caaggagagc     1680

agcagccacc accccggcau cgccgaguuc cccagcagag gcaagagcag cagcuacagc     1740

aagcaguuca ccagcagcac cagcuacaac agaggcgaca gcaccuucga gagcaagagc     1800

uacaagaugg ccgacgaggc cggcagcgag gccgaccacg agggcaccca cagcaccaag     1860

agaggccacg ccaagagcag acccgugaga gacugcgacg acgugcugca gacccacccc     1920

agcggcaccc agagcggcau cuucaacauc aagcugcccg gcagcagcaa gaucuucagc     1980

guguacugcg accaggagac cagccugggc ggcuggcugc ugauccagca gagaauggac     2040

ggcagccuga acuucaacag aaccuggcag gacuacaaga gaggcuucgg cagccugaac     2100

gacgagggcg agggcgaguu cuggcugggc aacgacuacc ugcaccugcu gacccagaga     2160

ggcagcgugc ugagagugga gcuggaggac ugggccggca acgaggccua cgccgaguac     2220

cacuucagag ugggcagcga ggccgagggc uacgcccugc aggugagcag cuacgagggc     2280

accgccggcg acgcccugau cgagggcagc guggaggagg gcgccgagua caccagccac     2340

aacaacaugc aguucagcac cuucgacaga gacgccgacc agugggagga gaacugcgcc     2400

gagguguacg gcggcggcug gugguacaac aacugccagg ccgccaaccu gaacggcauc     2460

uacuaccccg gcggcagcua cgaccccaga aacaacagcc ccuacgagau cgagaacggc     2520

gugguguggg ugagcuucag aggcgccgac uacagccuga gagccgugag aaugaagauc     2580

agaccccugg ugacccagug a                                               2601


<210>  8555
<211>  2601
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAA17056

<400>  8555
auguucagca ugagaaucgu gugccugguc cucuccguug ugggcaccgc cuggacagcu       60

gacucugggg agggagauuu ucuggccgaa ggcgggggag ugcggggccc ccgcgucgug      120

gagagacacc agagcgcgug uaaggacucc gauuggccuu ucugcucuga cgaagauugg      180

aacuacaaau guccgagcgg gugccggaug aagggacuua uugacgaggu uaaucaagau      240

uuuacgaacc gcaucaauaa acugaagaac ucccucuucg aauaucagaa aaauaacaag      300

gacucucaua gccugaccac aaauauuaug gagauccuua gaggcgauuu uuccagcgcu      360

aacaaucggg acaacaccua caaucgcgug ucugaggauc ugagaucccg gauugaaguc      420

cucaagcgca aagugaucga gaagguucag cacauccagc ugcugcaaaa gaacgugaga      480

gcccagcucg ucgacaugaa gcggcuggaa guggauauug acaucaaaau ucgcagcugu      540

agaggcucuu gcucccgggc ccuugcucgc gagguggacc ugaaggauua ugaggaccag      600

cagaagcaac ucgaacaggu caucgccaaa gaucugcuuc ccagcagaga ccggcagcau      660

cugccucuca uuaagaugaa acccguuccu gaucuggugc ccgggaauuu caagucucag      720

cugcaaaaag ugccuccgga guggaaggcu cucacagaca ugccccagau gagaauggaa      780

cuggagcgcc cuggaggcaa cgaaaucacc agagggggau ccacaagcua cggcaccggg      840

uccgagacgg agucuccccg gaauccuagc uccgccggaa gcuggaacuc uggcuccagc      900

ggccccgggu cuaccggaaa ccgcaauccg ggcagcuccg ggacaggagg caccgcgaca      960

uggaaaccug ggucuagcgg acccggcucc accggcagcu ggaacucugg guccagcgga     1020

acgggcucua cagggaauca gaacccugga agcccccggc ccggcuccac cgggacaugg     1080

aauccuggcu ccucugaaag aggaagcgcc ggccacugga ccuccgaguc uagcgucucc     1140

gggagcaccg gacaauggca uucugaaucc ggcagcuuuc gcccggauuc ucccgggucc     1200

ggaaacgcuc ggccuaauaa ccccgacugg ggcacauucg aggaagugag cgggaauguu     1260

ucuccuggca cgagacgcga guaucacacc gagaaacuug ugacaagcaa gggagauaaa     1320

gaacugcgga ccggcaagga gaaagucaca uccgggagca ccacgacaac cagacgcucu     1380

uguuccaaga ccgugacaaa aaccguuauu ggacccgacg gccacaagga agugacaaag     1440

gaggucguga cgagcgaaga uggguccgac ugcccggagg ccauggaccu cggaacccug     1500

ucuggcaucg ggacacuuga uggcuuucgg cauagacacc cugacgaggc ugccuucuuu     1560

gauaccgcga gcacaggaaa aaccuucccc ggcuuuuucu ccccuaugcu gggggaguuc     1620

gucucugaaa cggaaagccg gggauccgag ucuggcaucu uuaccaacac aaaggagagc     1680

uccagccauc accccgggau ugccgaguuc ccuucucgcg gaaaauccag cucuuacucc     1740

aagcaguuua ccagcucuac auccuauaau agaggcgaca gcaccuucga auccaaaagc     1800

uacaagaugg cugaugaagc cgggucugag gcugaccacg aaggcacgca uagcacaaag     1860

cggggacacg ccaaauccag acccgugcgc gauugugacg auguucucca gacccauccg     1920

ucuggcacac agagcgggau cuuuaacauu aagcugccug gauccucuaa aaucuucagc     1980

guguacugcg accaagagac cucccugggc ggguggcucc ugauucagca gcggauggau     2040

ggaucucuua auuuuaacag aaccuggcag gacuauaagc gcggcuucgg cagccugaau     2100

gaugaggggg aaggagaguu uuggcucggc aacgacuacc ugcaccuucu gacacaaaga     2160

ggguccgucc uccgggugga acuggaggac ugggccggaa acgaggcuua ugcggaauac     2220

cauuuccgcg uuggcagcga ggccgaaggg uaugcucucc aggugucuuc cuacgaggga     2280

acggccggcg augcccugau cgaaggcagc gucgaggaag gggcugagua uaccucucac     2340

aauaacaugc aguuuuccac auucgacaga gaugccgacc agugggagga aaauugugcg     2400

gagguguacg gaggcgggug gugguacaac aauugccaag cugccaaccu gaauggaauc     2460

uauuaccccg gcgggagcua ugauccccgg aacaauuccc cuuacgaaau ugagaacgga     2520

gugguuuggg ucucuuuucg cggcgccgac uauagccuua gagcugugcg gaugaaaauc     2580

cgcccgcugg ugacccagug a                                               2601


<210>  8556
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__P02675

<400>  8556

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  8557
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAA18024

<400>  8557
augaaaagga ugguuucuug gagcuuccac aaacuuaaaa ccaugaaaca ucuauuauug       60

cuacuauugu guguuuuucu aguuaagucc caagguguca acgacaauga ggaggguuuc      120

uucagugccc guggucaucg accccuugac aagaagagag aagaggcucc cagccugagg      180

ccugccccac cgcccaucag uggagguggc uaucgggcuc guccagccaa agcagcugcc      240

acucaaaaga aaguagaaag aaaagccccu gaugcuggag gcugucuuca cgcugaccca      300

gaccuggggg uguugugucc uacaggaugu caguugcaag aggcuuugcu acaacaggaa      360

aggccaauca gaaauagugu ugaugaguua aauaacaaug uggaagcugu uucccagacc      420

uccucuucuu ccuuucagua cauguauuug cugaaagacc uguggcaaaa gaggcagaag      480

caaguaaaag auaaugaaaa uguagucaau gaguacuccu cagaacugga aaagcaccaa      540

uuauauauag augagacugu gaauagcaau aucccaacua accuucgugu gcuucguuca      600

auccuggaaa accugagaag caaaauacaa aaguuagaau cugaugucuc agcucaaaug      660

gaauauuguc gcaccccaug cacugucagu ugcaauauuc cugugguguc uggcaaagaa      720

ugugaggaaa uuaucaggaa aggaggugaa acaucugaaa uguaucucau ucaaccugac      780

aguucuguca aaccguauag aguauacugu gacaugaaua cagaaaaugg aggauggaca      840

gugauucaga accgucaaga cgguaguguu gacuuuggca ggaaauggga uccauauaaa      900

cagggauuug gaaauguugc aaccaacaca gaugggaaga auuacugugg ccuaccaggu      960

gaauauuggc uuggaaauga uaaaauuagc cagcuuacca ggaugggacc cacagaacuu     1020

uugauagaaa uggaggacug gaaaggagac aaaguaaagg cucacuaugg aggauucacu     1080

guacagaaug aagccaacaa auaccagauc ucagugaaca aauacagagg aacagccggu     1140

aaugcccuca uggauggagc aucucagcug augggagaaa acaggaccau gaccauucac     1200

aacggcaugu ucuucagcac guaugacaga gacaaugacg gcugguuaac aucagauccc     1260

agaaaacagu guucuaaaga agacgguggu ggaugguggu auaauagaug ucaugcagcc     1320

aauccaaacg gcagauacua cuggggugga caguacaccu gggacauggc aaagcauggc     1380

acagaugaug guguaguaug gaugaauugg aaggggucau gguacucaau gaggaagaug     1440

aguaugaaga ucaggcccuu cuucccacag caauag                               1476


<210>  8558
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAA18024

<400>  8558
augaagcgca uggugagcug guccuuccac aagcugaaga ccaugaagca ccuccugcug       60

cuccugcugu gcgucuuccu cgucaagagc cagggcguga acgacaacga ggagggguuc      120

uucuccgccc ggggccaccg cccccuggac aagaagcggg aggaggcccc gagccugcgc      180

cccgcgcccc cgcccaucuc cgggggcggg uaccgggccc gccccgccaa ggccgccgcg      240

acccagaaga agguggagcg gaaggccccc gacgccggcg gcugccucca cgccgacccc      300

gaccuggggg ugcugugccc gacgggcugc cagcuccagg aggcgcugcu gcagcaggag      360

cgccccaucc ggaacagcgu ggacgagcuc aacaacaacg ucgaggccgu gucccagacc      420

agcuccagcu ccuuccagua cauguaccug cugaaggacc ucuggcagaa gcgccagaag      480

caggucaagg acaacgagaa cguggugaac gaguacagcu ccgagcugga gaagcaccag      540

cuguacaucg acgagaccgu gaacagcaac auccccacca accuccgggu ccugcgcucc      600

auccuggaga accuccggag caagauccag aagcuggagu ccgacgugag cgcccagaug      660

gaguacugcc gcacgcccug caccgugucc ugcaacaucc cggucgugag cgggaaggag      720

ugcgaggaga ucauccggaa gggcggggag accagcgaga uguaccugau ccagcccgac      780

uccagcguga agcccuaccg cgucuacugc gacaugaaca ccgagaacgg cggcuggacg      840

gugauccaga accggcagga cggguccgug gacuucggcc gcaaguggga ccccuacaag      900

cagggguucg gcaacgucgc caccaacacc gacggcaaga acuacugcgg gcucccgggc      960

gaguacuggc uggggaacga caagaucagc cagcugaccc ggaugggccc cacggagcuc     1020

cugaucgaga uggaggacug gaagggggac aaggugaagg cccacuacgg cggcuucacc     1080

gugcagaacg aggcgaacaa guaccagauc uccgucaaca aguaccgcgg gaccgccggc     1140

aacgcccuga uggacggggc cagccagcuc augggcgaga accggaccau gacgauccac     1200

aacgggaugu ucuucuccac cuacgaccgc gacaacgacg gcuggcugac cagcgacccc     1260

cgcaagcagu gcuccaagga ggacggcggg ggcugguggu acaaccggug ccacgccgcg     1320

aaccccaacg ggcgcuacua cuggggcggg caguacaccu gggacauggc caagcacggc     1380

acggacgacg gcguggucug gaugaacugg aaggggagcu gguacuccau gcggaagaug     1440

agcaugaaga uccgcccguu cuucccccag caguga                               1476


<210>  8559
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAA18024

<400>  8559
augaagcgca uggucuccug guccuuccac aagcucaaga ccaugaagca ccuccuccuc       60

cuccuccucu gcgucuuccu cgucaagucc cagggcguca acgacaacga ggagggcuuc      120

uucuccgccc gcggccaccg cccccucgac aagaagcgcg aggaggcccc cucccuccgc      180

cccgcccccc cccccaucuc cggcggcggc uaccgcgccc gccccgccaa ggccgccgcc      240

acccagaaga aggucgagcg caaggccccc gacgccggcg gcugccucca cgccgacccc      300

gaccucggcg uccucugccc caccggcugc cagcuccagg aggcccuccu ccagcaggag      360

cgccccaucc gcaacuccgu cgacgagcuc aacaacaacg ucgaggccgu cucccagacc      420

uccuccuccu ccuuccagua cauguaccuc cucaaggacc ucuggcagaa gcgccagaag      480

caggucaagg acaacgagaa cgucgucaac gaguacuccu ccgagcucga gaagcaccag      540

cucuacaucg acgagaccgu caacuccaac auccccacca accuccgcgu ccuccgcucc      600

auccucgaga accuccgcuc caagauccag aagcucgagu ccgacgucuc cgcccagaug      660

gaguacugcc gcacccccug caccgucucc ugcaacaucc ccgucgucuc cggcaaggag      720

ugcgaggaga ucauccgcaa gggcggcgag accuccgaga uguaccucau ccagcccgac      780

uccuccguca agcccuaccg cgucuacugc gacaugaaca ccgagaacgg cggcuggacc      840

gucauccaga accgccagga cggcuccguc gacuucggcc gcaaguggga ccccuacaag      900

cagggcuucg gcaacgucgc caccaacacc gacggcaaga acuacugcgg ccuccccggc      960

gaguacuggc ucggcaacga caagaucucc cagcucaccc gcaugggccc caccgagcuc     1020

cucaucgaga uggaggacug gaagggcgac aaggucaagg cccacuacgg cggcuucacc     1080

guccagaacg aggccaacaa guaccagauc uccgucaaca aguaccgcgg caccgccggc     1140

aacgcccuca uggacggcgc cucccagcuc augggcgaga accgcaccau gaccauccac     1200

aacggcaugu ucuucuccac cuacgaccgc gacaacgacg gcuggcucac cuccgacccc     1260

cgcaagcagu gcuccaagga ggacggcggc ggcugguggu acaaccgcug ccacgccgcc     1320

aaccccaacg gccgcuacua cuggggcggc caguacaccu gggacauggc caagcacggc     1380

accgacgacg gcgucgucug gaugaacugg aagggcuccu gguacuccau gcgcaagaug     1440

uccaugaaga uccgccccuu cuucccccag caguga                               1476


<210>  8560
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAA18024

<400>  8560
augaagagaa uggugagcug guccuuccac aaacugaaga ccaugaaaca ucuccuucug       60

uuguuacugu gcgucuuucu aguuaagucu cagggcguga acgacaauga ggaaggguuc      120

uuuucagcca ggggacaccg gccccucgau aaaaagcgcg aggaagcucc uagucugcga      180

ccagcaccgc ccccuaucag cgguggcggg uaccgugcca gaccagcgaa ggcugccgca      240

acacaaaaga agguagagag gaaagccccc gacgcuggag gcugucuuca ugcagauccu      300

gaccugggug uguugugccc aacugggugu cagcuccagg aagcccugcu gcagcaagag      360

cggcccauuc gcaacuccgu cgaugagcuc aauaacaaug uggaagcugu uucucagacg      420

ucgucaagca guuuccagua uauguacuua cugaaggacc uuuggcagaa aagacaaaaa      480

caggugaagg auaacgagaa ugucgugaac gaauauuccu cugaguugga gaaacaccag      540

cuguacauag acgaaaccgu aaauagcaac aucccuacaa aucuaagggu ucuccggucc      600

auucuggaga accuucgcuc aaagauccag aaacuggaaa gugaugugag cgcccaaaug      660

gaguauugcc gaacuccaug uaccgucucu ugcaauauuc cggugguguc cggaaaggaa      720

ugugaggaga ucauaagaaa aggcggcgaa acaucagaga uguacuugau ccagcccgac      780

agcaguguca agccuuauag gguuuacugc gauaugaaca ccgaaaaugg gggauggacu      840

gugauucaga accggcaaga cgguucugua gauuuuggcc guaaauggga cccauacaag      900

cagggguucg gaaacguggc gacaaauacc gacggcaaga acuauugugg ucuccccggg      960

gaguacuggc ugggaaauga uaaaaucucc caguuaacgc gcaugggccc uacugaacug     1020

cucauugaga uggaggacug gaagggcgau aaagucaagg cacauuaugg gggauuuacc     1080

gugcagaacg aagccaauaa auaccaaauc agcguuaaca aguauagagg uacagcuggc     1140

aaugcccuua uggacggggc aucgcagcug augggagaga acaggacuau gaccauacac     1200

aauggcaugu ucuuuucuac auacgaucgg gacaacgaug guugguugac cuccgaccca     1260

cgaaagcagu gcucaaaaga agaugggggc ggaugguggu auaaucgcug ucacgcugcc     1320

aaccccaaug gcagauacua cuggggaggg caguauacgu gggacauggc gaagcauggu     1380

acugaugacg gcguggucug gaugaacugg aaagggaguu gguacagcau gaggaagaug     1440

uccaugaaaa uucggccguu cuuuccucaa caguga                               1476


<210>  8561
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAA18024

<400>  8561
augaagagaa uggugagcug gagcuuccac aagcugaaga ccaugaagca ccugcugcug       60

cugcugcugu gcguguuccu ggugaagagc cagggcguga acgacaacga ggagggcuuc      120

uucagcgcca gaggccacag accccuggac aagaagagag aggaggcccc cagccugaga      180

cccgcccccc cccccaucag cggcggcggc uacagagcca gacccgccaa ggccgccgcc      240

acccagaaga agguggagag aaaggccccc gacgccggcg gcugccugca cgccgacccc      300

gaccugggcg ugcugugccc caccggcugc cagcugcagg aggcccugcu gcagcaggag      360

agacccauca gaaacagcgu ggacgagcug aacaacaacg uggaggccgu gagccagacc      420

agcagcagca gcuuccagua cauguaccug cugaaggacc uguggcagaa gagacagaag      480

caggugaagg acaacgagaa cguggugaac gaguacagca gcgagcugga gaagcaccag      540

cuguacaucg acgagaccgu gaacagcaac auccccacca accugagagu gcugagaagc      600

auccuggaga accugagaag caagauccag aagcuggaga gcgacgugag cgcccagaug      660

gaguacugca gaacccccug caccgugagc ugcaacaucc ccguggugag cggcaaggag      720

ugcgaggaga ucaucagaaa gggcggcgag accagcgaga uguaccugau ccagcccgac      780

agcagcguga agcccuacag aguguacugc gacaugaaca ccgagaacgg cggcuggacc      840

gugauccaga acagacagga cggcagcgug gacuucggca gaaaguggga ccccuacaag      900

cagggcuucg gcaacguggc caccaacacc gacggcaaga acuacugcgg ccugcccggc      960

gaguacuggc ugggcaacga caagaucagc cagcugacca gaaugggccc caccgagcug     1020

cugaucgaga uggaggacug gaagggcgac aaggugaagg cccacuacgg cggcuucacc     1080

gugcagaacg aggccaacaa guaccagauc agcgugaaca aguacagagg caccgccggc     1140

aacgcccuga uggacggcgc cagccagcug augggcgaga acagaaccau gaccauccac     1200

aacggcaugu ucuucagcac cuacgacaga gacaacgacg gcuggcugac cagcgacccc     1260

agaaagcagu gcagcaagga ggacggcggc ggcugguggu acaacagaug ccacgccgcc     1320

aaccccaacg gcagauacua cuggggcggc caguacaccu gggacauggc caagcacggc     1380

accgacgacg gcguggugug gaugaacugg aagggcagcu gguacagcau gagaaagaug     1440

agcaugaaga ucagacccuu cuucccccag caguga                               1476


<210>  8562
<211>  1476
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAA18024

<400>  8562
augaagagaa uggugagcug guccuuccac aaacugaaga ccaugaaaca ucuccugcuu       60

cugcuccugu gcgucuuucu uguuaagucu cagggcguga acgacaauga ggaaggguuc      120

uuuagcgccc ggggacaccg cccccuggau aaaaagagag aggaagcucc uucccuccgg      180

ccggcgcccc cucccaucuc uggcggggga uaccgcgcca gaccugcuaa ggccgccgcu      240

acacagaaaa agguggagcg gaaagccccc gacgcuggcg ggugucugca ugccgauccu      300

gaccugggag uccucugccc gacgggcugu caacugcagg aagcgcuucu gcagcaagag      360

cgccccauua gaaacagcgu ggaugagcuc aauaacaaug uugaagccgu gucccagacc      420

ucuagcucca gcuuccagua uauguaccug cuuaaggacc uguggcagaa acggcaaaag      480

caggucaagg auaacgagaa ugugguuaac gaauauucuu ccgagcucga gaaacaccag      540

cuguacaucg acgaaacagu gaauagcaac auuccuacca aucugcgcgu ccucagaucu      600

auccuggaga accuucgguc caagauucag aaacuggaaa gcgauguguc ugcucaaaug      660

gaguauugcc gcacacccug uaccgugucc ugcaauaucc cugucguuag cggcaaggaa      720

ugugaggaga ucauuagaaa agggggagaa acauccgaga uguaccucau ccagcccgac      780

ucuagcguga agccguaucg gguguacugc gauaugaaca ccgaaaaugg cggguggacg      840

gucauucaga accgccaaga cggauccgug gauuuuggca gaaaauggga cccuuacaag      900

cagggguucg gaaacguugc caccaauaca gacggcaaga acuauugugg ccugcccggg      960

gaguacuggc uuggaaauga uaaaaucagc cagcugaccc ggaugggccc uacagaacuc     1020

cugauugaga uggaggacug gaagggggau aaagugaagg cucauuaugg aggcuuuacc     1080

guccagaacg aagccaauaa auaccaaauc ucugugaaca aguauagagg gacggcggga     1140

aaugcccuga uggacggcgc uucccagcuc augggcgaga accgcacaau gaccauucac     1200

aaugggaugu ucuuuagcac auacgaucgg gacaacgaug gauggcugac cucugacccc     1260

agaaagcagu gcagcaaaga agauggcggg ggaugguggu auaaucgcug ucacgccgcu     1320

aaccccaaug gccgguacua cuggggcggg caguauaccu gggacauggc caagcaugga     1380

acagaugacg gcguugugug gaugaacugg aaaggguccu gguacucuau gagaaagaug     1440

agcaugaaaa uccgcccuuu cuuuccgcaa caguga                               1476


<210>  8563
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__P02679

<400>  8563

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  8564
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAK19752

<400>  8564
augaguuggu ccuugcaccc ccggaauuua auucucuacu ucuaugcucu uuuauuucuc       60

ucuucaacau guguagcaua uguugcuacc agagacaacu gcugcaucuu agaugaaaga      120

uucgguaguu auuguccaac uaccuguggc auugcagauu uccugucuac uuaucaaacc      180

aaaguagaca aggaucuaca gucuuuggaa gacaucuuac aucaaguuga aaacaaaaca      240

ucagaaguca aacagcugau aaaagcaauc caacucacuu auaauccuga ugaaucauca      300

aaaccaaaua ugauagacgc ugcuacuuug aaguccagga aaauguuaga agaaauuaug      360

aaauaugaag caucgauuuu aacacaugac ucaaguauuc gauauuugca ggaaauauau      420

aauucaaaua aucaaaagau uguuaaccug aaagagaagg uagcccagcu ugaagcacag      480

ugccaggaac cuugcaaaga cacggugcaa auccaugaua ucacugggaa agauugucaa      540

gacauugcca auaagggagc uaaacagagc gggcuuuacu uuauuaaacc ucugaaagcu      600

aaccagcaau ucuuagucua cugugaaauc gaugggucug gaaauggaug gacuguguuu      660

cagaagagac uugauggcag uguagauuuc aagaaaaacu ggauucaaua uaaagaagga      720

uuuggacauc ugucuccuac uggcacaaca gaauuuuggc ugggaaauga gaagauucau      780

uugauaagca cacagucugc caucccauau gcauuaagag uggaacugga agacuggaau      840

ggcagaacca guacugcaga cuaugccaug uucaaggugg gaccugaagc ugacaaguac      900

cgccuaacau augccuacuu cgcugguggg gaugcuggag augccuuuga uggcuuugau      960

uuuggcgaug auccuaguga caaguuuuuc acaucccaua auggcaugca guucaguacc     1020

ugggacaaug acaaugauaa guuugaaggc aacugugcug aacaggaugg aucugguugg     1080

uggaugaaca agugucacgc uggccaucuc aauggaguuu auuaccaagg uggcacuuac     1140

ucaaaagcau cuacuccuaa ugguuaugau aauggcauua uuugggccac uuggaaaacc     1200

cggugguauu ccaugaagaa aaccacuaug aagauaaucc cauucaacag acucacaauu     1260

ggagaaggac agcaacacca ccugggggga gccaaacagg ucagaccaga gcacccugcg     1320

gaaacagaau augacucacu uuacccugag gaugauuugu ag                        1362


<210>  8565
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAK19752

<400>  8565
augagcuggu cccugcaccc ccgcaaccuc auccuguacu ucuacgcccu gcucuuccug       60

agcuccaccu gcguggccua cgucgcgacc cgggacaacu gcugcauccu ggacgagcgc      120

uucggcagcu acugcccgac gaccugcggg aucgccgacu uccucuccac cuaccagacc      180

aagguggaca aggaccugca gagccuggag gacauccucc accaggugga gaacaagacg      240

uccgagguca agcagcugau caaggccauc cagcugaccu acaaccccga cgagagcucc      300

aagcccaaca ugaucgacgc cgccacccuc aagagccgga agaugcugga ggagaucaug      360

aaguacgagg cguccauccu gacccacgac agcuccaucc gcuaccucca ggagaucuac      420

aacagcaaca accagaagau cgugaaccug aaggagaagg uggcccagcu ggaggcccag      480

ugccaggagc ccugcaagga cacgguccag auccacgaca ucaccggcaa ggacugccag      540

gacaucgcca acaagggggc gaagcagucc ggccucuacu ucaucaagcc gcugaaggcc      600

aaccagcagu uccuggugua cugcgagauc gacgggagcg gcaacggcug gaccguguuc      660

cagaagcggc ucgacggguc cgucgacuuc aagaagaacu ggauccagua caaggagggc      720

uucgggcacc ugagccccac cggcacgacc gaguucuggc uggggaacga gaagauccac      780

cucaucucca cccagagcgc cauccccuac gcccugcgcg uggagcugga ggacuggaac      840

ggccggacca gcacggccga cuacgcgaug uucaaggugg gccccgaggc cgacaaguac      900

cgccucaccu acgccuacuu cgccgggggc gacgccgggg acgcguucga cggcuucgac      960

uucggcgacg acccguccga caaguucuuc accagccaca acgggaugca guucuccacc     1020

ugggacaacg acaacgacaa guucgagggc aacugcgccg agcaggacgg gagcggcugg     1080

uggaugaaca agugccacgc cgggcaccug aacggcgucu acuaccaggg cgggacguac     1140

uccaaggcca gcacccccaa cggcuacgac aacgggauca ucugggccac cuggaagacc     1200

cggugguacu ccaugaagaa gacgaccaug aagaucaucc ccuucaaccg ccugaccauc     1260

ggcgaggggc agcagcacca ccucggcggc gcgaagcagg ugcggcccga gcacccggcc     1320

gagaccgagu acgacagccu guaccccgag gacgaccugu ga                        1362


<210>  8566
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAK19752

<400>  8566
auguccuggu cccuccaccc ccgcaaccuc auccucuacu ucuacgcccu ccucuuccuc       60

uccuccaccu gcgucgccua cgucgccacc cgcgacaacu gcugcauccu cgacgagcgc      120

uucggcuccu acugccccac caccugcggc aucgccgacu uccucuccac cuaccagacc      180

aaggucgaca aggaccucca gucccucgag gacauccucc accaggucga gaacaagacc      240

uccgagguca agcagcucau caaggccauc cagcucaccu acaaccccga cgaguccucc      300

aagcccaaca ugaucgacgc cgccacccuc aagucccgca agaugcucga ggagaucaug      360

aaguacgagg ccuccauccu cacccacgac uccuccaucc gcuaccucca ggagaucuac      420

aacuccaaca accagaagau cgucaaccuc aaggagaagg ucgcccagcu cgaggcccag      480

ugccaggagc ccugcaagga caccguccag auccacgaca ucaccggcaa ggacugccag      540

gacaucgcca acaagggcgc caagcagucc ggccucuacu ucaucaagcc ccucaaggcc      600

aaccagcagu uccucgucua cugcgagauc gacggcuccg gcaacggcug gaccgucuuc      660

cagaagcgcc ucgacggcuc cgucgacuuc aagaagaacu ggauccagua caaggagggc      720

uucggccacc ucucccccac cggcaccacc gaguucuggc ucggcaacga gaagauccac      780

cucaucucca cccaguccgc cauccccuac gcccuccgcg ucgagcucga ggacuggaac      840

ggccgcaccu ccaccgccga cuacgccaug uucaaggucg gccccgaggc cgacaaguac      900

cgccucaccu acgccuacuu cgccggcggc gacgccggcg acgccuucga cggcuucgac      960

uucggcgacg accccuccga caaguucuuc accucccaca acggcaugca guucuccacc     1020

ugggacaacg acaacgacaa guucgagggc aacugcgccg agcaggacgg cuccggcugg     1080

uggaugaaca agugccacgc cggccaccuc aacggcgucu acuaccaggg cggcaccuac     1140

uccaaggccu ccacccccaa cggcuacgac aacggcauca ucugggccac cuggaagacc     1200

cgcugguacu ccaugaagaa gaccaccaug aagaucaucc ccuucaaccg ccucaccauc     1260

ggcgagggcc agcagcacca ccucggcggc gccaagcagg uccgccccga gcaccccgcc     1320

gagaccgagu acgacucccu cuaccccgag gacgaccucu ga                        1362


<210>  8567
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAK19752

<400>  8567
augagcuggu cccugcaccc cagaaaccuc auccuuuacu ucuaugcccu guuguuuuua       60

ucuucaaccu gcguggcuua cgucgcaaca agggacaauu guugcauucu ggaugagcgg      120

uucggcaguu auuguccuac uacgugcggg auagccgacu uucuaagcac cuaccagaca      180

aagguugaua aagaccucca aucccuggaa gauauccuuc aucaggugga gaacaagacu      240

ucugaaguaa aacagcugau uaaggcgauc caguugaccu auaauccaga cgagucguca      300

aaaccgaaca ugauugaugc ugccacacuc aagagccgca agaugcugga agagaucaug      360

aaauacgagg caaguauacu gacccacgac uccucuaucc gauaucucca agaaauuuac      420

aauagcaaca aucagaagau cgugaacuua aaagagaagg ucgcccagcu ggaagcucag      480

ugucaagagc ccugcaaaga uacugugcag auucaugaca ucacaggaaa ggauugucag      540

gacauagcaa auaagggugc caaacagucc ggccuuuacu ucauuaagcc uuugaaagcu      600

aaccaacagu uucugguuua uugcgagauc gaugggucag gaaauggcug gaccguguuc      660

cagaagcguc uagacgguag ugucgacuuu aaaaagaacu ggauucaaua caaagaaggg      720

uucggacacc ucagcccaac gggcacuacc gaguuuuggc ugggcaauga aaagauccau      780

cuuaucucua cacaguccgc cauucccuau gcgcugagag uggaguugga agauuggaac      840

gggaggacuu caaccgcaga cuacgccaug uucaagguag gaccugaggc ugauaaauau      900

cggcucacau acgccuauuu ugcugguggc gacgcagggg augccuucga cggauuugau      960

uucggcgacg auccaagcga caaguucuuu accagucaca augguaugca guucucuacg     1020

ugggauaacg acaacgacaa auuugagggg aauugugcgg aacaggaugg auccggcugg     1080

uggaugaaca agugccacgc cggccaucug aaugggguuu acuaccaagg agguacuuau     1140

agcaaagcau cgacacccaa cggcuacgac aaugggauaa ucugggcuac cuggaagacu     1200

cgcugguauu cuaugaagaa aacaaccaug aagauuaucc cuuucaacag auuaacgaua     1260

ggagagggcc agcagcacca ucuggguggg gccaaacagg ugaggccaga acacccggcu     1320

gagaccgaau acgauucccu cuaucccgag gacgaucuuu ga                        1362


<210>  8568
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAK19752

<400>  8568
augagcugga gccugcaccc cagaaaccug auccuguacu ucuacgcccu gcuguuccug       60

agcagcaccu gcguggccua cguggccacc agagacaacu gcugcauccu ggacgagaga      120

uucggcagcu acugccccac caccugcggc aucgccgacu uccugagcac cuaccagacc      180

aagguggaca aggaccugca gagccuggag gacauccugc accaggugga gaacaagacc      240

agcgagguga agcagcugau caaggccauc cagcugaccu acaaccccga cgagagcagc      300

aagcccaaca ugaucgacgc cgccacccug aagagcagaa agaugcugga ggagaucaug      360

aaguacgagg ccagcauccu gacccacgac agcagcauca gauaccugca ggagaucuac      420

aacagcaaca accagaagau cgugaaccug aaggagaagg uggcccagcu ggaggcccag      480

ugccaggagc ccugcaagga caccgugcag auccacgaca ucaccggcaa ggacugccag      540

gacaucgcca acaagggcgc caagcagagc ggccuguacu ucaucaagcc ccugaaggcc      600

aaccagcagu uccuggugua cugcgagauc gacggcagcg gcaacggcug gaccguguuc      660

cagaagagac uggacggcag cguggacuuc aagaagaacu ggauccagua caaggagggc      720

uucggccacc ugagccccac cggcaccacc gaguucuggc ugggcaacga gaagauccac      780

cugaucagca cccagagcgc cauccccuac gcccugagag uggagcugga ggacuggaac      840

ggcagaacca gcaccgccga cuacgccaug uucaaggugg gccccgaggc cgacaaguac      900

agacugaccu acgccuacuu cgccggcggc gacgccggcg acgccuucga cggcuucgac      960

uucggcgacg accccagcga caaguucuuc accagccaca acggcaugca guucagcacc     1020

ugggacaacg acaacgacaa guucgagggc aacugcgccg agcaggacgg cagcggcugg     1080

uggaugaaca agugccacgc cggccaccug aacggcgugu acuaccaggg cggcaccuac     1140

agcaaggcca gcacccccaa cggcuacgac aacggcauca ucugggccac cuggaagacc     1200

agaugguaca gcaugaagaa gaccaccaug aagaucaucc ccuucaacag acugaccauc     1260

ggcgagggcc agcagcacca ccugggcggc gccaagcagg ugagacccga gcaccccgcc     1320

gagaccgagu acgacagccu guaccccgag gacgaccugu ga                        1362


<210>  8569
<211>  1362
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAK19752

<400>  8569
augagcuggu cccugcaccc cagaaaccuc auccuguacu ucuaugcccu ucuguuucuc       60

ucuagcacau gcguggcuua cgucgccacc cgggacaauu guugcauucu ggaugagcgc      120

uucggcuccu auuguccuac gaccugcggg aucgcggacu uucuuucuac auaccagacc      180

aagguugaua aagaccugca aagccucgaa gauauucugc aucaggugga gaacaagaca      240

uccgaaguga aacagcugau caaggcuauu cagcucaccu auaauccgga cgagucuagc      300

aaacccaaca ugaucgaugc cgccacacug aaguccagaa agaugcuuga agagaucaug      360

aaauacgagg cuagcauucu gacccacgac ucuuccaucc gguaucucca agaaauuuac      420

aauagcaaca aucagaagau cgucaaccug aaagagaagg uggcccagcu ugaagcucag      480

ugucaagagc cuugcaaaga uacgguucag auucaugaca ucaccggaaa ggauugucag      540

gacauugcca auaagggcgc gaaacagucu gggcuguacu ucaucaagcc ccucaaagcc      600

aaccaacagu uucuggugua uugcgagauc gauggauccg gcaaugggug gacagucuuc      660

cagaagcgcc uggacggaag cguggacuuu aaaaagaacu ggauucaaua caaagaaggc      720

uucggccacc ucucuccuac cgggacaacc gaguuuuggc ugggaaauga aaagauccau      780

cuuauuucca cgcagagcgc uauccccuau gcccugagag uugagcucga agauuggaac      840

ggccggacau ccaccgcuga cuacgccaug uucaaggugg ggccugaggc ggauaaauau      900

cgccugacau acgccuauuu ugcuggaggc gacgccgggg augcuuucga cggauuugau      960

uucggcgacg auccgucuga caaguucuuu accagccaca auggcaugca guucuccacc     1020

ugggauaacg acaacgacaa auuugagggg aauugugccg aacaggaugg aagcggcugg     1080

uggaugaaca agugccacgc cgggcaucuu aauggagucu acuaccaagg cgggacauau     1140

ucuaaggcuu ccacgcccaa cggauacgac aauggcauua ucugggcgac cuggaaaaca     1200

agaugguaua gcaugaagaa aaccacaaug aagaucauuc cuuucaaccg gcugaccauc     1260

ggcgaggggc agcagcacca ucucggaggc gccaaacagg ugcgccccga acacccugcu     1320

gagacggaau acgauucucu guaucccgag gacgaucugu ga                        1362


<210>  8570
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__Q08830

<400>  8570

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  8571
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAH07047

<400>  8571
auggcaaagg uguucaguuu cauccuuguu accaccgcuc uuacaauggg cagggaaauu       60

ucggcgcucg aggacugugc ccaggagcag augcggcuca gagcccaggu gcgccugcuu      120

gagacccggg ucaaacagca acaggucaag aucaagcagc uuuugcagga gaaugaaguc      180

caguuccuug auaaaggaga ugagaauacu gucauugauc uuggaagcaa gaggcaguau      240

gcagauuguu cagagauuuu caaugauggg uauaagcuca guggauuuua caaaaucaaa      300

ccucuccaga gcccagcaga auuuucuguu uauugugaca uguccgaugg aggaggaugg      360

acuguaauuc agagacgauc ugauggcagu gaaaacuuua acagaggaug gaaagacuau      420

gaaaauggcu uuggaaauuu uguccaaaaa cauggugaau auuggcuggg caauaaaaau      480

cuucacuucu ugaccacuca agaagacuac acuuuaaaaa ucgaccuugc agauuuugaa      540

aaaaauagcc guuaugcaca auauaagaau uucaaaguug gagaugaaaa gaauuucuac      600

gaguugaaua uuggggaaua uucuggaaca gcuggagauu cccuugcggg gaauuuucau      660

ccugaggugc aguggugggc uagucaccaa agaaugaaau ucagcacgug ggacagagau      720

caugacaacu augaagggaa cugcgcagaa gaagaucagu cuggcuggug guuuaacagg      780

ugucacucug caaaccugaa ugguguauac uacagcggcc ccuacacggc uaaaacagac      840

aaugggauug ucugguacac cuggcauggg uggugguauu cucugaaauc ugugguuaug      900

aaaauuaggc caaaugauuu uauuccaaau guaauuuaa                             939


<210>  8572
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAH07047

<400>  8572
auggccaagg uguucagcuu cauccugguc accaccgccc ucacgauggg ccgcgagauc       60

uccgcgcugg aggacugcgc ccaggagcag augcggcugc gcgcccaggu gcggcuccug      120

gagacccgcg ugaagcagca gcaggucaag aucaagcagc ugcuccagga gaacgaggug      180

caguuccugg acaaggggga cgagaacacc gugaucgacc ugggcagcaa gcggcaguac      240

gccgacugcu ccgagaucuu caacgacggg uacaagcuca gcggcuucua caagaucaag      300

ccccugcagu ccccggccga guucagcguc uacugcgaca uguccgacgg gggcggcugg      360

accgugaucc agcgccggag cgacgggucc gagaacuuca accgcggcug gaaggacuac      420

gagaacgggu ucggcaacuu cgugcagaag cacggggagu acuggcuggg caacaagaac      480

cuccacuucc ugacgaccca ggaggacuac acccugaaga ucgaccucgc ggacuucgag      540

aagaacagcc gguacgccca guacaagaac uucaaggucg gcgacgagaa gaacuucuac      600

gagcugaaca ucggggagua cuccggcacc gccggggaca gccuggccgg caacuuccac      660

cccgaggugc aguggugggc gucccaccag cgcaugaagu ucagcacgug ggaccgggac      720

cacgacaacu acgagggcaa cugcgccgag gaggaccagu ccggguggug guucaaccgc      780

ugccacagcg ccaaccucaa cggcguguac uacuccgggc ccuacaccgc caagaccgac      840

aacggcaucg ucugguacac cuggcacggg uggugguaca gccugaaguc cguggugaug      900

aagauccggc ccaacgacuu caucccgaac gucaucuga                             939


<210>  8573
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAH07047

<400>  8573
auggccaagg ucuucuccuu cauccucguc accaccgccc ucaccauggg ccgcgagauc       60

uccgcccucg aggacugcgc ccaggagcag augcgccucc gcgcccaggu ccgccuccuc      120

gagacccgcg ucaagcagca gcaggucaag aucaagcagc uccuccagga gaacgagguc      180

caguuccucg acaagggcga cgagaacacc gucaucgacc ucggcuccaa gcgccaguac      240

gccgacugcu ccgagaucuu caacgacggc uacaagcucu ccggcuucua caagaucaag      300

ccccuccagu cccccgccga guucuccguc uacugcgaca uguccgacgg cggcggcugg      360

accgucaucc agcgccgcuc cgacggcucc gagaacuuca accgcggcug gaaggacuac      420

gagaacggcu ucggcaacuu cguccagaag cacggcgagu acuggcucgg caacaagaac      480

cuccacuucc ucaccaccca ggaggacuac acccucaaga ucgaccucgc cgacuucgag      540

aagaacuccc gcuacgccca guacaagaac uucaaggucg gcgacgagaa gaacuucuac      600

gagcucaaca ucggcgagua cuccggcacc gccggcgacu cccucgccgg caacuuccac      660

cccgaggucc aguggugggc cucccaccag cgcaugaagu ucuccaccug ggaccgcgac      720

cacgacaacu acgagggcaa cugcgccgag gaggaccagu ccggcuggug guucaaccgc      780

ugccacuccg ccaaccucaa cggcgucuac uacuccggcc ccuacaccgc caagaccgac      840

aacggcaucg ucugguacac cuggcacggc uggugguacu cccucaaguc cgucgucaug      900

aagauccgcc ccaacgacuu cauccccaac gucaucuga                             939


<210>  8574
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAH07047

<400>  8574
auggccaagg uguucagcuu uauccugguc accacagcuc ucacuauggg cagagagauu       60

uccgcacuug aagacugcgc ccaggagcaa augaggcugc gggcgcaggu ucgcuuguua      120

gaaacgcgag ugaaacagca gcaaguaaag auaaaacagc ugcuacagga gaacgaagug      180

caguuccucg auaaggggga cgagaauacc gucaucgauc ugggaucuaa acgucaauac      240

gcugacuguu cagagauuuu uaacgauggu uauaaacuua guggcuucua caagaucaag      300

ccccugcaga gcccugccga auuuuccgug uauugcgaca ugucugaugg gggaggcugg      360

acaguuauuc agagaagguc ggacgguuca gagaauuuca accgggggug gaaggauuac      420

gaaaauggau uuggcaacuu cgugcagaaa cacggcgagu auugguuggg gaauaagaac      480

cuccauuuuc ugacuaccca agaggacuac acacugaaaa ucgaucucgc agacuucgaa      540

aagaauagcc gcuaugccca guacaagaac uuuaaagucg gagaugagaa gaauuucuac      600

gaauuaaaca uaggugagua uaguggcacc gcuggggacu cccuggcagg aaauuuucac      660

ccagaagugc aguggugggc cucucaucaa agaaugaaau ucagcacuug ggacagggau      720

cacgacaacu acgagggcaa uugugcugag gaagaucagu ccgguuggug guucaaccgg      780

ugccauucag ccaaccuuaa ugggguauau uacaguggac cguauacagc gaagaccgac      840

aacggcaucg uuugguacac guggcacggc uggugguaua gcuugaaauc uguggucaug      900

aagauucgcc ccaaugauuu uaucccuaac gugauuuga                             939


<210>  8575
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAH07047

<400>  8575
auggccaagg uguucagcuu cauccuggug accaccgccc ugaccauggg cagagagauc       60

agcgcccugg aggacugcgc ccaggagcag augagacuga gagcccaggu gagacugcug      120

gagaccagag ugaagcagca gcaggugaag aucaagcagc ugcugcagga gaacgaggug      180

caguuccugg acaagggcga cgagaacacc gugaucgacc ugggcagcaa gagacaguac      240

gccgacugca gcgagaucuu caacgacggc uacaagcuga gcggcuucua caagaucaag      300

ccccugcaga gccccgccga guucagcgug uacugcgaca ugagcgacgg cggcggcugg      360

accgugaucc agagaagaag cgacggcagc gagaacuuca acagaggcug gaaggacuac      420

gagaacggcu ucggcaacuu cgugcagaag cacggcgagu acuggcuggg caacaagaac      480

cugcacuucc ugaccaccca ggaggacuac acccugaaga ucgaccuggc cgacuucgag      540

aagaacagca gauacgccca guacaagaac uucaaggugg gcgacgagaa gaacuucuac      600

gagcugaaca ucggcgagua cagcggcacc gccggcgaca gccuggccgg caacuuccac      660

cccgaggugc aguggugggc cagccaccag agaaugaagu ucagcaccug ggacagagac      720

cacgacaacu acgagggcaa cugcgccgag gaggaccaga gcggcuggug guucaacaga      780

ugccacagcg ccaaccugaa cggcguguac uacagcggcc ccuacaccgc caagaccgac      840

aacggcaucg ugugguacac cuggcacggc uggugguaca gccugaagag cguggugaug      900

aagaucagac ccaacgacuu cauccccaac gugaucuga                             939


<210>  8576
<211>  939
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAH07047

<400>  8576
auggccaagg uguucagcuu uauccugguc accacagcuc ucacgauggg cagagagauu       60

uccgcccugg aagacugcgc gcaggagcaa augcggcuuc gcgcucaggu uagacugcuc      120

gaaacccggg ugaaacagca gcaagugaag aucaaacagc ugcuucagga gaacgaaguc      180

caguuccugg auaaggggga cgagaauaca gugauugauc ucggaucuaa acgccaauac      240

gccgacugua gcgagaucuu uaacgauggc uauaagcugu ccggguucua caagauuaaa      300

ccccugcagu cuccugccga auuuagcguu uauugcgaca uguccgaugg aggcgggugg      360

accgugaucc agagacgguc ugacggaagc gagaauuuca accgcggcug gaaggauuac      420

gaaaauggcu uugggaacuu cguccagaaa cacggagagu auuggcucgg caauaagaac      480

cugcauuuuc uuacaaccca agaggacuac acacugaaaa ucgaucucgc ugacuucgaa      540

aagaacucca gauaugccca guacaagaau uuuaaagugg gggaugagaa gaauuucuac      600

gaacugaaca uuggagagua uagcggcacc gcuggggacu cucuugccgg aaauuuucac      660

ccggaaguuc aguggugggc gucccaucaa cggaugaaau ucagcacgug ggaccgcgau      720

cacgacaacu acgagggcaa uugugccgag gaagaucagu cuggcuggug guucaacaga      780

ugccauuccg cuaaccugaa ugggguguau uacagcggac ccuauaccgc caagacagac      840

aacggcaucg ucugguacac cuggcacggg uggugguauu cucucaaauc cguggugaug      900

aagauucggc cuaaugauuu uauccccaac gucauuuga                             939


<210>  8577
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__Q14314

<400>  8577

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu 
        195                 200                 205             


Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser 
    210                 215                 220                 


Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val 
225                 230                 235                 240 


Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala 
                245                 250                 255     


Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys 
            260                 265                 270         


Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys 
        275                 280                 285             


Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu 
    290                 295                 300                 


Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr 
305                 310                 315                 320 


Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn 
                325                 330                 335     


Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp 
            340                 345                 350         


Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser 
        355                 360                 365             


Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys 
    370                 375                 380                 


Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly 
385                 390                 395                 400 


Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala 
                405                 410                 415     


His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile 
            420                 425                 430         


Arg Pro Lys His Phe Lys Pro 
        435                 


<210>  8578
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAD10825

<400>  8578
augaagcugg cuaacuggua cuggcugagc ucagcuguuc uugccacuua cgguuuuuug       60

guuguggcaa acaaugaaac agaggaaauu aaagaugaaa gagcaaagga ugucugccca      120

gugagacuag aaagcagagg gaaaugcgaa gaggcagggg agugccccua ccagguaagc      180

cugccccccu ugacuauuca gcucccgaag caauucagca ggaucgagga gguguucaaa      240

gaaguccaaa accucaagga aaucguaaau agucuaaaga aaucuugcca agacugcaag      300

cugcaggcug augacaacgg agacccaggc agaaacggac uguuguuacc caguacagga      360

gccccgggag agguugguga uaacagaguu agagaauuag agagugaggu uaacaagcug      420

uccucugagc uaaagaaugc caaagaggag aucaauguac uucauggucg ccuggagaag      480

cugaaucuug uaaauaugaa caacauagaa aauuauguug acagcaaagu ggcaaaucua      540

acauuuguug ucaauaguuu ggauggcaaa uguucaaagu gucccagcca agaacaaaua      600

cagucacguc caguucaaca ucuaauauau aaagauugcu cugacuacua cgcaauaggc      660

aaaagaagca gugagaccua cagaguuaca ccugauccca aaaauaguag cuuugaaguu      720

uacugugaca uggagaccau ggggggaggc uggacagugc ugcaggcacg ucucgauggg      780

agcaccaacu ucaccagaac auggcaagac uacaaagcag gcuuuggaaa ccucagaagg      840

gaauuuuggc uggggaacga uaaaauucau cuucugacca agaguaagga aaugauucug      900

agaauagauc uugaagacuu uaaugguguc gaacuauaug ccuuguauga ucaguuuuau      960

guggcuaaug aguuucucaa auaucguuua cacguuggua acuauaaugg cacagcugga     1020

gaugcauuac guuucaacaa acauuacaac cacgaucuga aguuuuucac cacuccagau     1080

aaagacaaug aucgauaucc uucugggaac ugugggcugu acuacaguuc aggcuggugg     1140

uuugaugcau gucuuucugc aaacuuaaau ggcaaauauu aucaccaaaa auacagaggu     1200

guccguaaug ggauuuucug ggguaccugg ccugguguaa gugaggcaca cccugguggc     1260

uacaaguccu ccuucaaaga ggcuaagaug augaucagac ccaagcacuu uaagccauaa     1320


<210>  8579
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAD10825

<400>  8579
augaagcugg ccaacuggua cuggcucagc uccgccgugc uggcgaccua cggcuuccug       60

gucguggcca acaacgagac cgaggagauc aaggacgagc gcgccaagga cgugugcccc      120

guccggcucg agagccgcgg gaagugcgag gaggccggcg agugcccgua ccaggugucc      180

cugccgcccc ugacgaucca gcuccccaag caguucagcc ggaucgagga gguguucaag      240

gagguccaga accugaagga gaucgugaac ucccugaaga aguccugcca ggacugcaag      300

cuccaggccg acgacaacgg ggaccccggc cgcaacgggc ugcugcuccc cagcaccggc      360

gcgcccggcg agguggggga caaccggguc cgcgagcugg agagcgaggu gaacaagcug      420

uccagcgagc ucaagaacgc caaggaggag aucaacgugc ugcacggccg gcuggagaag      480

cucaaccugg ucaacaugaa caacaucgag aacuacgugg acuccaaggu ggccaaccug      540

accuucgucg ugaacagccu cgacgggaag ugcuccaagu gccccagcca ggagcagauc      600

cagucccgcc cggugcagca ccugaucuac aaggacugca gcgacuacua cgccaucggc      660

aagcggucca gcgagaccua ccgcgucacg cccgacccca agaacuccag cuucgaggug      720

uacugcgaca uggagaccau gggcgggggc uggaccgugc ugcaggcgcg gcucgacggg      780

agcaccaacu ucacgcgcac cuggcaggac uacaaggccg gcuucgggaa ccugcggcgc      840

gaguucuggc ugggcaacga caagauccac cuccugacca aguccaagga gaugauccug      900

cggaucgacc ucgaggacuu caacggcguc gagcuguacg cccuguacga ccaguucuac      960

guggccaacg aguuccucaa guaccgccug cacgugggga acuacaacgg caccgccggg     1020

gacgcgcugc gguucaacaa gcacuacaac cacgaccuca aguucuucac gacccccgac     1080

aaggacaacg accgcuaccc gagcggcaac ugcgggcugu acuacuccag cggcuggugg     1140

uucgacgccu gccuguccgc caaccucaac ggcaaguacu accaccagaa guaccgcggg     1200

guccggaacg gcaucuucug ggggaccugg cccggcguga gcgaggccca ccccgggggc     1260

uacaagucca gcuucaagga ggccaagaug augauccggc ccaagcacuu caagccguga     1320


<210>  8580
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAD10825

<400>  8580
augaagcucg ccaacuggua cuggcucucc uccgccgucc ucgccaccua cggcuuccuc       60

gucgucgcca acaacgagac cgaggagauc aaggacgagc gcgccaagga cgucugcccc      120

guccgccucg agucccgcgg caagugcgag gaggccggcg agugccccua ccaggucucc      180

cucccccccc ucaccaucca gcuccccaag caguucuccc gcaucgagga ggucuucaag      240

gagguccaga accucaagga gaucgucaac ucccucaaga aguccugcca ggacugcaag      300

cuccaggccg acgacaacgg cgaccccggc cgcaacggcc uccuccuccc cuccaccggc      360

gcccccggcg aggucggcga caaccgcguc cgcgagcucg aguccgaggu caacaagcuc      420

uccuccgagc ucaagaacgc caaggaggag aucaacgucc uccacggccg ccucgagaag      480

cucaaccucg ucaacaugaa caacaucgag aacuacgucg acuccaaggu cgccaaccuc      540

accuucgucg ucaacucccu cgacggcaag ugcuccaagu gccccuccca ggagcagauc      600

cagucccgcc ccguccagca ccucaucuac aaggacugcu ccgacuacua cgccaucggc      660

aagcgcuccu ccgagaccua ccgcgucacc cccgacccca agaacuccuc cuucgagguc      720

uacugcgaca uggagaccau gggcggcggc uggaccgucc uccaggcccg ccucgacggc      780

uccaccaacu ucacccgcac cuggcaggac uacaaggccg gcuucggcaa ccuccgccgc      840

gaguucuggc ucggcaacga caagauccac cuccucacca aguccaagga gaugauccuc      900

cgcaucgacc ucgaggacuu caacggcguc gagcucuacg cccucuacga ccaguucuac      960

gucgccaacg aguuccucaa guaccgccuc cacgucggca acuacaacgg caccgccggc     1020

gacgcccucc gcuucaacaa gcacuacaac cacgaccuca aguucuucac cacccccgac     1080

aaggacaacg accgcuaccc cuccggcaac ugcggccucu acuacuccuc cggcuggugg     1140

uucgacgccu gccucuccgc caaccucaac ggcaaguacu accaccagaa guaccgcggc     1200

guccgcaacg gcaucuucug gggcaccugg cccggcgucu ccgaggccca ccccggcggc     1260

uacaaguccu ccuucaagga ggccaagaug augauccgcc ccaagcacuu caagcccuga     1320


<210>  8581
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAD10825

<400>  8581
augaagcugg ccaacuggua cuggcucagc uccgcugugc uugcaaccua uggcuuccug       60

gucguugcca auaacgagac agaagagauc aaagacgaaa gagcgaagga ugugugcccc      120

guaagguugg agucucgggg gaaaugugaa gaggcuggag agugcccuua ccagguguca      180

uuaccaccgc ugacuauuca acuacccaag caguuuaguc gcauagaaga ggucuucaaa      240

gaagugcaga aucucaagga gaucguuaac agccugaaga aauccuguca ggacugcaaa      300

cuucaagccg augacaaugg ugauccuggc cgaaacgggc uguugcuccc aucuacggga      360

gcacccggcg agguggguga caaucguguc agagaacugg agucggaagu gaacaagcug      420

ucaagcgagc ucaagaaugc caaagaagag auuaacguau uacacgggag gcuggagaaa      480

cuuaauuugg uuaacaugaa uaacaucgaa aauuaugugg auaguaaggu cgcuaaccug      540

accuuugugg ugaacucccu agacggaaag uguucuaagu gcccuagcca ggagcagauu      600

cagucccggc caguccaaca ucucaucuac aaagauuguu cagacuauua cgcaauaggc      660

aagcgcagua gcgaaacaua uagaguuacu cccgauccua aaaauucuuc cuucgaggug      720

uacugcgaca uggaaaccau gggcggggga uggacaguac ugcaggccag gcuugauggu      780

ucaaccaacu uuacucggac auggcaggac uacaaggcug gcuucgggaa ucugcgccga      840

gaguuuuggu ugggaaacga caaaauccac cuccugacca agagcaagga gaugauuuua      900

agaaucgauc uggaagacuu caauggcgug gagcucuaug cccuuuacga ucaguuuuau      960

gucgcgaacg aguuccugaa auacagguug caugugggua auuauaacgg gacggcagga     1020

gacgcccuac gguuuaauaa gcacuacaac caugaucuga aauucuuuac uaccccagac     1080

aaggauaaug accguuaucc gaguggcaac uguggccucu acuacucuuc cggguggugg     1140

uucgaugcuu gccugagcgc caaucuuaac ggaaaauauu accaccaaaa guaucgcggu     1200

guuagaaaug gcauuuucug ggggacaugg cccggagugu cggaagcaca cccuggcggu     1260

uacaagucuu ccuuuaaaga agcuaagaug augaucaggc caaaacauuu caagcccuga     1320


<210>  8582
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAD10825

<400>  8582
augaagcugg ccaacuggua cuggcugagc agcgccgugc uggccaccua cggcuuccug       60

gugguggcca acaacgagac cgaggagauc aaggacgaga gagccaagga cgugugcccc      120

gugagacugg agagcagagg caagugcgag gaggccggcg agugccccua ccaggugagc      180

cugccccccc ugaccaucca gcugcccaag caguucagca gaaucgagga gguguucaag      240

gaggugcaga accugaagga gaucgugaac agccugaaga agagcugcca ggacugcaag      300

cugcaggccg acgacaacgg cgaccccggc agaaacggcc ugcugcugcc cagcaccggc      360

gcccccggcg aggugggcga caacagagug agagagcugg agagcgaggu gaacaagcug      420

agcagcgagc ugaagaacgc caaggaggag aucaacgugc ugcacggcag acuggagaag      480

cugaaccugg ugaacaugaa caacaucgag aacuacgugg acagcaaggu ggccaaccug      540

accuucgugg ugaacagccu ggacggcaag ugcagcaagu gccccagcca ggagcagauc      600

cagagcagac ccgugcagca ccugaucuac aaggacugca gcgacuacua cgccaucggc      660

aagagaagca gcgagaccua cagagugacc cccgacccca agaacagcag cuucgaggug      720

uacugcgaca uggagaccau gggcggcggc uggaccgugc ugcaggccag acuggacggc      780

agcaccaacu ucaccagaac cuggcaggac uacaaggccg gcuucggcaa ccugagaaga      840

gaguucuggc ugggcaacga caagauccac cugcugacca agagcaagga gaugauccug      900

agaaucgacc uggaggacuu caacggcgug gagcuguacg cccuguacga ccaguucuac      960

guggccaacg aguuccugaa guacagacug cacgugggca acuacaacgg caccgccggc     1020

gacgcccuga gauucaacaa gcacuacaac cacgaccuga aguucuucac cacccccgac     1080

aaggacaacg acagauaccc cagcggcaac ugcggccugu acuacagcag cggcuggugg     1140

uucgacgccu gccugagcgc caaccugaac ggcaaguacu accaccagaa guacagaggc     1200

gugagaaacg gcaucuucug gggcaccugg cccggcguga gcgaggccca ccccggcggc     1260

uacaagagca gcuucaagga ggccaagaug augaucagac ccaagcacuu caagcccuga     1320


<210>  8583
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAD10825

<400>  8583
augaagcugg ccaacuggua cuggcucagc uccgcugugc uggccaccua uggcuuccuu       60

gucguugcga auaacgagac agaagagauc aaagacgaaa gagcuaagga ugugugcccc      120

gugcggcugg agucucgcgg gaaaugugaa gaggccggag agugcccuua ccaggucagc      180

cucccgcccc ugacgauuca acuuccuaag caguuuucca gaaucgaaga gguguucaaa      240

gaaguucaga aucugaagga gauugugaac ucucucaaga aaagcuguca ggacugcaag      300

cugcaagccg augacaaugg cgaucccggg cggaacggac ugcuccugcc uuccaccggc      360

gcucccgggg aggucggaga caaucgcgug agagaacuug agucugaagu uaacaaacug      420

agcuccgagc ucaagaaugc caaagaagag aucaacgugc ugcacggccg gcuugagaag      480

cugaaucucg ucaacaugaa uaacauugaa aauuaugugg auagcaaggu ggcuaaccug      540

acauuugucg uuaacucucu ggacggcaaa uguuccaagu gcccuagcca ggagcagauc      600

cagucucgcc cggugcaaca ucucaucuac aaagauuguu ccgacuauua cgccauuggg      660

aagagaagcu cugaaaccua ucgggugaca cccgauccua aaaauuccag cuucgagguc      720

uacugcgaca uggaaaccau gggaggcggg uggacagugc ugcaggcgcg ccuugaugga      780

uccaccaacu uuacgagaac cuggcaggac uacaaggccg gcuucgggaa ucugcggcgc      840

gaguuuuggc ucggaaacga caaaauccau cugcuuacaa agucuaagga gaugauucug      900

agaaucgauc ucgaagacuu caauggcguu gagcuguaug cucuguacga ucaguuuuau      960

guggccaacg aguuccucaa auaccggcug cacgucggca auuauaacgg gaccgcugga     1020

gacgcccuuc gcuuuaauaa gcacuacaac caugaucuga aauucuuuac aacccccgac     1080

aaggauaaug acagauaucc uagcggcaac ugugggcucu acuacuccag cggauggugg     1140

uucgaugcgu gccugucugc caaucuuaac ggcaaauauu accaccaaaa guauagaggg     1200

gugcggaaug gaauuuucug gggcacgugg cccggcguuu ccgaagcuca cccuggggga     1260

uacaagagcu cuuuuaaaga agccaagaug augauccgcc cgaaacauuu caagcccuga     1320


<210>  8584
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__Q6UXM4

<400>  8584

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Asn Cys Arg Glu Leu Leu Ser Gln Gly Ala Thr Leu Ser Gly Trp Tyr 
                85                  90                  95      


His Leu Cys Leu Pro Glu Gly Arg Ala Leu Pro Val Phe Cys Asp Met 
            100                 105                 110         


Asp Thr Glu Gly Gly Gly Trp Leu Val Phe Gln Arg Arg Gln Asp Gly 
        115                 120                 125             


Ser Val Asp Phe Phe Arg Ser Trp Ser Ser Tyr Arg Ala Gly Phe Gly 
    130                 135                 140                 


Asn Gln Glu Ser Glu Phe Trp Leu Gly Asn Glu Asn Leu His Gln Leu 
145                 150                 155                 160 


Thr Leu Gln Gly Asn Trp Glu Leu Arg Val Glu Leu Glu Asp Phe Asn 
                165                 170                 175     


Gly Asn Arg Thr Phe Ala His Tyr Ala Thr Phe Arg Leu Leu Gly Glu 
            180                 185                 190         


Val Asp His Tyr Gln Leu Ala Leu Gly Lys Phe Ser Glu Gly Thr Ala 
        195                 200                 205             


Gly Asp Ser Leu Ser Leu His Ser Gly Arg Pro Phe Thr Thr Tyr Asp 
    210                 215                 220                 


Ala Asp His Asp Ser Ser Asn Ser Asn Cys Ala Val Ile Val His Gly 
225                 230                 235                 240 


Ala Trp Trp Tyr Ala Ser Cys Tyr Arg Ser Asn Leu Asn Gly Arg Tyr 
                245                 250                 255     


Ala Val Ser Glu Ala Ala Ala His Lys Tyr Gly Ile Asp Trp Ala Ser 
            260                 265                 270         


Gly Arg Gly Val Gly His Pro Tyr Arg Arg Val Arg Met Met Leu Arg 
        275                 280                 285             






<210>  8585
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__AAQ88650

<400>  8585
auggaucuac uguggauccu gcccucccug uggcuucucc ugcuuggggg gccugccugc       60

cugaagaccc aggaacaccc cagcugccca ggacccaggg aacuggaagc cagcaaaguu      120

guccuccugc ccaguugucc cggagcucca ggaaguccug gggagaaggg agccccaggu      180

ccucaagggc caccuggacc accaggcaag augggcccca agggugagcc aggccccaga      240

aacugccggg agcuguugag ccagggcgcc accuugagcg gcugguacca ucugugccua      300

ccugagggca gggcccuccc agucuuuugu gacauggaca ccgagggggg cggcuggcug      360

guguuucaga ggcgccagga ugguucugug gauuucuucc gcucuugguc cuccuacaga      420

gcagguuuug ggaaccaaga gucugaauuc uggcugggaa augagaauuu gcaccagcuu      480

acucuccagg guaacuggga gcugcgggua gagcuggaag acuuuaaugg uaaccguacu      540

uucgcccacu augcgaccuu ccgccuccuc ggugagguag accacuacca gcuggcacug      600

ggcaaguucu cagagggcac ugcaggggau ucccugagcc uccacagugg gaggcccuuu      660

accaccuaug acgcugacca cgauucaagc aacagcaacu gugcagugau uguccacggu      720

gccugguggu augcauccug uuaccgauca aaucucaaug gucgcuaugc agugucugag      780

gcugccgccc acaaauaugg cauugacugg gccucaggcc gugguguggg ccaccccuac      840

cgcaggguuc ggaugaugcu ucgauag                                          867


<210>  8586
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__AAQ88650

<400>  8586
auggaccugc ucuggauccu gcccagccug uggcuccugc ugcucggcgg gccggccugc       60

cugaagaccc aggagcaccc cuccugcccc ggcccccgcg agcuggaggc cagcaaggug      120

guccuccugc cguccugccc cggggcgccc ggcagccccg gggagaaggg cgccccgggc      180

ccccaggggc cgcccggccc gcccgggaag augggcccca agggggagcc cggcccccgg      240

aacugccgcg agcugcucuc ccagggcgcc acccugagcg ggugguacca ccugugccuc      300

cccgagggcc gggcccugcc cguguucugc gacauggaca cggagggcgg gggcuggcug      360

guguuccagc gccggcagga cggguccguc gacuucuucc gcagcugguc cagcuaccgg      420

gccggcuucg ggaaccagga guccgaguuc uggcucggca acgagaaccu gcaccagcug      480

acccuccagg ggaacuggga gcugcgcgug gagcuggagg acuucaacgg caaccggacc      540

uucgcgcacu acgccaccuu ccgccuccug ggcgaggugg accacuacca gcuggcccuc      600

gggaaguuca gcgagggcac ggccggggac ucccugagcc ugcacuccgg ccggcccuuc      660

accaccuacg acgcggacca cgacagcucc aacagcaacu gcgccgucau cgugcacggg      720

gccugguggu acgccuccug cuaccgcagc aaccucaacg gccgguacgc cgugagcgag      780

gcggccgccc acaaguacgg caucgacugg gccuccgggc gcggcgucgg gcacccguac      840

cggcgcgugc ggaugaugcu gcgcuga                                          867


<210>  8587
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__AAQ88650

<400>  8587
auggaccucc ucuggauccu ccccucccuc uggcuccucc uccucggcgg ccccgccugc       60

cucaagaccc aggagcaccc cuccugcccc ggcccccgcg agcucgaggc cuccaagguc      120

guccuccucc ccuccugccc cggcgccccc ggcucccccg gcgagaaggg cgcccccggc      180

ccccagggcc cccccggccc ccccggcaag augggcccca agggcgagcc cggcccccgc      240

aacugccgcg agcuccucuc ccagggcgcc acccucuccg gcugguacca ccucugccuc      300

cccgagggcc gcgcccuccc cgucuucugc gacauggaca ccgagggcgg cggcuggcuc      360

gucuuccagc gccgccagga cggcuccguc gacuucuucc gcuccugguc cuccuaccgc      420

gccggcuucg gcaaccagga guccgaguuc uggcucggca acgagaaccu ccaccagcuc      480

acccuccagg gcaacuggga gcuccgcguc gagcucgagg acuucaacgg caaccgcacc      540

uucgcccacu acgccaccuu ccgccuccuc ggcgaggucg accacuacca gcucgcccuc      600

ggcaaguucu ccgagggcac cgccggcgac ucccucuccc uccacuccgg ccgccccuuc      660

accaccuacg acgccgacca cgacuccucc aacuccaacu gcgccgucau cguccacggc      720

gccugguggu acgccuccug cuaccgcucc aaccucaacg gccgcuacgc cgucuccgag      780

gccgccgccc acaaguacgg caucgacugg gccuccggcc gcggcgucgg ccaccccuac      840

cgccgcgucc gcaugaugcu ccgcuga                                          867


<210>  8588
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__AAQ88650

<400>  8588
auggaccugc ucuggauccu ucccagccug ugguuguuac ugcuaggcgg gccugccugc       60

cucaagaccc aggagcaccc auccuguccg ggacccagag aacuggaggc uucuaaagug      120

guccuucugc cuucaugccc aggugcaccc ggcaguccug gggaaaaggg agccccaggc      180

ccccaagguc cuccagggcc gcccggaaaa augggcccua agggcgagcc agggcccagg      240

aacugucggg aauugcucag ccagggagcg acacuguccg guugguacca ucugugccuc      300

ccugagggcc gcgcuuuacc aguuuucugu gauauggaca cugaaggggg aggcuggcug      360

guguuucagc gacgucagga ugguucugua gacuucuuua gaucgugguc aagcuauagg      420

gccggguucg gaaaucaaga gagugaguuu uggcuuggca acgaaaauuu gcaccagcug      480

acgcuacagg gcaacuggga gcuccgggug gagcuggaag auuucaaugg gaaccgcacc      540

uuugcacauu acgccacauu cagacuucug ggagaggucg accacuauca guuggcucuc      600

gguaaauuuu ccgaaggcac ugcaggggau ucucugagcu uacauuccgg aaggcccuuc      660

accacauacg acgccgauca cgacucaagu aauagcaacu gcgcugugau uguucacggc      720

gccugguggu augcgucuug uuaccggucc aaucugaacg gucgcuaugc agugucagag      780

gccgcugccc auaaguacgg gauagauugg gcaagcggcc gaggagucgg ccacccguac      840

agaagggugc ggaugaugcu ccguuga                                          867


<210>  8589
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__AAQ88650

<400>  8589
auggaccugc uguggauccu gcccagccug uggcugcugc ugcugggcgg ccccgccugc       60

cugaagaccc aggagcaccc cagcugcccc ggccccagag agcuggaggc cagcaaggug      120

gugcugcugc ccagcugccc cggcgccccc ggcagccccg gcgagaaggg cgcccccggc      180

ccccagggcc cccccggccc ccccggcaag augggcccca agggcgagcc cggccccaga      240

aacugcagag agcugcugag ccagggcgcc acccugagcg gcugguacca ccugugccug      300

cccgagggca gagcccugcc cguguucugc gacauggaca ccgagggcgg cggcuggcug      360

guguuccaga gaagacagga cggcagcgug gacuucuuca gaagcuggag cagcuacaga      420

gccggcuucg gcaaccagga gagcgaguuc uggcugggca acgagaaccu gcaccagcug      480

acccugcagg gcaacuggga gcugagagug gagcuggagg acuucaacgg caacagaacc      540

uucgcccacu acgccaccuu cagacugcug ggcgaggugg accacuacca gcuggcccug      600

ggcaaguuca gcgagggcac cgccggcgac agccugagcc ugcacagcgg cagacccuuc      660

accaccuacg acgccgacca cgacagcagc aacagcaacu gcgccgugau cgugcacggc      720

gccugguggu acgccagcug cuacagaagc aaccugaacg gcagauacgc cgugagcgag      780

gccgccgccc acaaguacgg caucgacugg gccagcggca gaggcguggg ccaccccuac      840

agaagaguga gaaugaugcu gagauga                                          867


<210>  8590
<211>  867
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__AAQ88650

<400>  8590
auggaccugc ucuggauccu gcccagccuu uggcugcucc ugcuuggcgg gccugccugc       60

cugaagaccc aggagcaccc guccuguccc ggaccuagag aacucgaggc uucuaaagug      120

guccugcugc ccagcugccc uggcgccccc ggguccccug gagaaaaggg cgcgccgggg      180

ccccaaggac cucccggccc ucccggcaaa auggggccga agggagagcc uggcccccgg      240

aacugucgcg aacuccuguc ucagggggcu acacuuagcg gaugguacca ucugugccuc      300

ccugagggca gagcccugcc cguuuucugu gauauggaca cggaaggggg aggcuggcuu      360

guguuucagc ggcgccagga uggcuccgug gacuucuuua gaucuuggag cuccuaucgg      420

gccggguucg gaaaucaaga gagcgaguuu uggcugggca acgaaaaucu ccaccagcug      480

acccugcagg ggaacuggga gcuccgcguc gagcuggaag auuucaaugg aaacagaaca      540

uuugcucauu acgccaccuu ccggcuucug ggcgaggugg accacuauca gcucgcucug      600

gggaaauuuu cugaaggaac agccggcgau ucccuuagcc ugcauucugg ccgccccuuc      660

accacauacg acgcggauca cgacuccagc aauucuaacu gcgccguuau ugugcacggg      720

gcuugguggu augccuccug uuacagaagc aaucucaacg gacgguaugc ugucuccgag      780

gccgcggccc auaaguacgg caucgauugg gcuucugggc gcggaguggg ccacccuuac      840

agacggguuc gcaugaugcu gagauga                                          867


<210>  8591
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__Q9UE34

<400>  8591

Met Gln Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn 
1               5                   10                  15      


Gly Asn Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp 
            20                  25                  30          


Gly Gly Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp 
        35                  40                  45              


Phe Trp Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser 
    50                  55                  60                  


Gly Glu Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala 
65                  70                  75                  80  


Gly Asp Tyr Ser Ile Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val 
                85                  90                  95      


Phe Ala Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr 
            100                 105                 110         


Arg Leu His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser 
        115                 120                 125             


Tyr His Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser 
    130                 135                 140                 


Leu Leu Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg 
145                 150                 155                 160 


Asn Cys His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp 
                165                 170                 175     


His Gln Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val 
            180                 185                 190         


Pro Phe Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala 
        195                 200                 205             


Gly Gly Gly 
    210     


<210>  8592
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Fibrinogen__Homo_sapiens__CAA50740

<400>  8592
augcagaacg gagccggugc cuccaggacc agcaccaucu uccucaacgg caaccgcgag       60

cggccccuga acguguuuug cgacauggag acugaugggg gcggcuggcu gguguuccag      120

cgccgcaugg auggacagac agacuucugg agggacuggg aggacuaugc ccaugguuuu      180

gggaacaucu cuggagaguu cuggcugggc aaugaggccc ugcacagccu gacacaggca      240

ggugacuacu ccauccgcgu ggaccugcgg gcuggggacg aggcuguguu cgcccaguac      300

gacuccuucc acguagacuc ggcugcggag uacuaccgcc uccacuugga gggcuaccac      360

ggcaccgcag gggacuccau gagcuaccac agcggcagug ucuucucugc ccgugaucgg      420

gaccccaaca gcuugcucau cuccugcgcu gucuccuacc gaggggccug gugguacagg      480

aacugccacu acgccaaccu caacgggcuc uacgggagca caguggacca ucagggagug      540

agcugguacc acuggaaggg cuucgaguuc ucggugcccu ucacggaaau gaagcugaga      600

ccaagaaacu uucgcucccc agcgggggga ggcuga                                636


<210>  8593
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Fibrinogen__Homo_sapiens__CAA50740

<400>  8593
augcagaacg gcgccggggc cagccgcacc uccaccaucu uccugaacgg caaccgggag       60

cgcccccuca acguguucug cgacauggag acggacgggg gcggguggcu ggucuuccag      120

cggcgcaugg acggccagac cgacuucugg cgggacuggg aggacuacgc gcacggcuuc      180

gggaacauca gcggcgaguu cuggcugggg aacgaggccc uccacucccu gacccaggcc      240

ggcgacuaca gcauccgcgu ggaccugcgg gccggggacg aggccguguu cgcgcaguac      300

gacuccuucc acgucgacag cgccgccgag uacuaccgcc uccaccugga gggcuaccac      360

ggcaccgccg gggacuccau gagcuaccac uccggcagcg uguucuccgc gcgggaccgc      420

gacccgaaca gccugcucau cuccugcgcc gugagcuacc gcggggccug gugguaccgg      480

aacugccacu acgccaaccu gaacggccug uacggcucca cggucgacca ccagggggug      540

agcugguacc acuggaaggg cuucgaguuc uccgugcccu ucaccgagau gaagcuccgg      600

ccccgcaacu uccggagccc cgccgggggc ggguga                                636


<210>  8594
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Fibrinogen__Homo_sapiens__CAA50740

<400>  8594
augcagaacg gcgccggcgc cucccgcacc uccaccaucu uccucaacgg caaccgcgag       60

cgcccccuca acgucuucug cgacauggag accgacggcg gcggcuggcu cgucuuccag      120

cgccgcaugg acggccagac cgacuucugg cgcgacuggg aggacuacgc ccacggcuuc      180

ggcaacaucu ccggcgaguu cuggcucggc aacgaggccc uccacucccu cacccaggcc      240

ggcgacuacu ccauccgcgu cgaccuccgc gccggcgacg aggccgucuu cgcccaguac      300

gacuccuucc acgucgacuc cgccgccgag uacuaccgcc uccaccucga gggcuaccac      360

ggcaccgccg gcgacuccau guccuaccac uccggcuccg ucuucuccgc ccgcgaccgc      420

gaccccaacu cccuccucau cuccugcgcc gucuccuacc gcggcgccug gugguaccgc      480

aacugccacu acgccaaccu caacggccuc uacggcucca ccgucgacca ccagggcguc      540

uccugguacc acuggaaggg cuucgaguuc uccguccccu ucaccgagau gaagcuccgc      600

ccccgcaacu uccgcucccc cgccggcggc ggcuga                                636


<210>  8595
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Fibrinogen__Homo_sapiens__CAA50740

<400>  8595
augcagaacg gcgccggggc uagcagaacc uccacaaucu uccugaaugg aaacagggag       60

cggccccuca auguguuuug cgacauggaa acugauggug gcggguggcu ugucuuccaa      120

cgccgaaugg acggacagac ggauuuuugg cgugacuggg aggauuacgc acacggcuuc      180

gguaacauuu cuggggaauu uuggcuggga aaugaggccu ugcauucauu aacccaggcg      240

ggcgacuaua guauaagagu ugaucugagg gcuggcgacg aagccguguu cgcacaguac      300

gauagcuuuc acguagacuc cgccgcugag uauuaccggc uacaucucga gggguaucac      360

ggaacagcag gggauucuau gucguaccau ucaggcagcg uguucagugc ccgcgacaga      420

gauccuaacu cccugcuuau cucuugugcu gucagcuaua ggggugccug gugguaccgg      480

aauugccacu acgcgaaccu gaauggauug uauggcucca cuguggacca ccaagguguu      540

ucaugguacc auuggaaggg guuugaguuc agugugccau uuaccgaaau gaaacuccgc      600

ccgcgaaacu ucagaagccc cgcaggaggc ggcuga                                636


<210>  8596
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Fibrinogen__Homo_sapiens__CAA50740

<400>  8596
augcagaacg gcgccggcgc cagcagaacc agcaccaucu uccugaacgg caacagagag       60

agaccccuga acguguucug cgacauggag accgacggcg gcggcuggcu gguguuccag      120

agaagaaugg acggccagac cgacuucugg agagacuggg aggacuacgc ccacggcuuc      180

ggcaacauca gcggcgaguu cuggcugggc aacgaggccc ugcacagccu gacccaggcc      240

ggcgacuaca gcaucagagu ggaccugaga gccggcgacg aggccguguu cgcccaguac      300

gacagcuucc acguggacag cgccgccgag uacuacagac ugcaccugga gggcuaccac      360

ggcaccgccg gcgacagcau gagcuaccac agcggcagcg uguucagcgc cagagacaga      420

gaccccaaca gccugcugau cagcugcgcc gugagcuaca gaggcgccug gugguacaga      480

aacugccacu acgccaaccu gaacggccug uacggcagca ccguggacca ccagggcgug      540

agcugguacc acuggaaggg cuucgaguuc agcgugcccu ucaccgagau gaagcugaga      600

cccagaaacu ucagaagccc cgccggcggc ggcuga                                636


<210>  8597
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Fibrinogen__Homo_sapiens__CAA50740

<400>  8597
augcagaacg gcgccggggc uagcagaacc uccacaaucu uccugaaugg aaaccgggag       60

cgcccccuca auguguuuug cgacauggaa acggauggcg ggggauggcu ggucuuccaa      120

agacggaugg acggccagac cgauuuuugg cgcgacuggg aggauuacgc ccacggguuc      180

ggaaacauuu cuggcgaauu uuggcuuggc aaugaggcgc ugcauagccu cacacaggcu      240

ggggacuauu ccaucagagu ugaucugcgg gccggagacg aagccguguu cgcucaguac      300

gauucuuuuc acguggacag cgccgcugag uauuaccgcc uucaucugga gggcuaucac      360

gggaccgccg gagauuccau gucuuaccau agcggcuccg ucuucagcgc gagagaccgg      420

gauccuaacu cucuccugau uuccugugcc gugagcuauc gcggggcuug gugguacaga      480

aauugccacu acgccaaccu gaauggacuc uauggcucua caguugacca ccaaggcgug      540

uccugguacc auuggaaggg guuugaguuc agcgucccgu uuaccgaaau gaaacugcgg      600

ccccgcaacu ucagaucucc ugcuggaggc ggguga                                636


<210>  8598
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  FOS__Homo_sapiens__A0A024RD16

<400>  8598

Met Leu Pro Thr Gln Ala Gly Ala Ala Ala Ala Leu Gly Arg Gly Ser 
1               5                   10                  15      


Ala Leu Gly Gly Ser Leu Asn Arg Thr Pro Thr Gly Arg Pro Gly Gly 
            20                  25                  30          


Gly Gly Gly Thr Arg Gly Ala Asn Gly Gly Arg Val Pro Gly Asn Gly 
        35                  40                  45              


Ala Gly Leu Gly Pro Gly Arg Leu Glu Arg Glu Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Thr Thr Pro Ala Pro Thr Ala Gly Ala Leu Tyr Ser Gly Ser Glu 
65                  70                  75                  80  


Gly Asp Ser Glu Ser Gly Glu Glu Glu Glu Leu Gly Ala Glu Arg Arg 
                85                  90                  95      


Gly Leu Lys Arg Ser Leu Ser Glu Met Glu Ile Gly Met Val Val Gly 
            100                 105                 110         


Gly Pro Glu Ala Ser Ala Ala Ala Thr Gly Gly Tyr Gly Pro Val Ser 
        115                 120                 125             


Gly Ala Val Ser Gly Ala Lys Pro Gly Lys Lys Thr Arg Gly Arg Val 
    130                 135                 140                 


Lys Ile Lys Met Glu Phe Ile Asp Asn Lys Leu Arg Arg Tyr Thr Thr 
145                 150                 155                 160 


Phe Ser Lys Arg Lys Thr Gly Ile Met Lys Lys Ala Tyr Glu Leu Ser 
                165                 170                 175     


Thr Leu Thr Gly Thr Gln Val Leu Leu Leu Val Ala Ser Glu Thr Gly 
            180                 185                 190         


His Val Tyr Thr Phe Ala Thr Arg Lys Leu Gln Pro Met Ile Thr Ser 
        195                 200                 205             


Glu Thr Gly Lys Ala Leu Ile Gln Thr Cys Leu Asn Ser Pro Asp Ser 
    210                 215                 220                 


Pro Pro Arg Ser Asp Pro Thr Thr Asp Gln Arg Met Ser Ala Thr Gly 
225                 230                 235                 240 


Phe Glu Glu Thr Asp Leu Thr Tyr Gln Val Ser Glu Ser Asp Ser Ser 
                245                 250                 255     


Gly Glu Thr Lys Asp Thr Leu Lys Pro Ala Phe Thr Val Thr Asn Leu 
            260                 265                 270         


Pro Gly Thr Thr Ser Thr Ile Gln Thr Ala Pro Ser Thr Ser Thr Thr 
        275                 280                 285             


Met Gln Val Ser Ser Gly Pro Ser Phe Pro Ile Thr Asn Tyr Leu Ala 
    290                 295                 300                 


Pro Val Ser Ala Ser Val Ser Pro Ser Ala Val Ser Ser Ala Asn Gly 
305                 310                 315                 320 


Thr Val Leu Lys Ser Thr Gly Ser Gly Pro Val Ser Ser Gly Gly Leu 
                325                 330                 335     


Met Gln Leu Pro Thr Ser Phe Thr Leu Met Pro Gly Gly Ala Val Ala 
            340                 345                 350         


Gln Gln Val Pro Val Gln Ala Ile Gln Val His Gln Ala Pro Gln Gln 
        355                 360                 365             


Ala Ser Pro Ser Arg Asp Ser Ser Thr Asp Leu Thr Gln Thr Ser Ser 
    370                 375                 380                 


Ser Gly Thr Val Thr Leu Pro Ala Thr Ile Met Thr Ser Ser Val Pro 
385                 390                 395                 400 


Thr Thr Val Gly Gly His Met Met Tyr Pro Ser Pro His Ala Val Met 
                405                 410                 415     


Tyr Ala Pro Thr Ser Gly Leu Gly Asp Gly Ser Leu Thr Val Leu Asn 
            420                 425                 430         


Ala Phe Ser Gln Ala Pro Ser Thr Met Gln Val Ser His Ser Gln Val 
        435                 440                 445             


Gln Glu Pro Gly Gly Val Pro Gln Val Phe Leu Thr Ala Ser Ser Gly 
    450                 455                 460                 


Thr Val Gln Ile Pro Val Ser Ala Val Gln Leu His Gln Met Ala Val 
465                 470                 475                 480 


Ile Gly Gln Gln Ala Gly Ser Ser Ser Asn Leu Thr Glu Leu Gln Val 
                485                 490                 495     


Val Asn Leu Asp Thr Ala His Ser Thr Lys Ser Glu 
            500                 505             


<210>  8599
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  FOS__Homo_sapiens__EAX04162

<400>  8599
auguuaccga cccaagcugg ggccgcggcg gcucugggcc ggggcucggc ccuggggggc       60

agccugaacc ggaccccgac ggggcggccg ggcggcggcg gcgggacacg cggggcuaac      120

gggggccggg uccccgggaa uggcgcgggg cucgggcccg gccgccugga gcgggaggcu      180

gcggcagcgg cggcaaccac cccggcgccc accgcggggg cccucuacag cggcagcgag      240

ggcgacucgg agucgggcga ggaggaggag cugggcgccg agcggcgcgg ccugaagcgg      300

agccugagcg agauggagau cgguauggug gucggugggc ccgaggcguc ggcagcggcc      360

accgggggcu acgggccggu gagcggcgcg gugagcgggg ccaagccggg uaagaagacc      420

cggggccgcg ugaagaucaa gauggaguuc aucgacaaca agcugcggcg cuacacgacc      480

uucagcaaga ggaagacggg caucaugaag aaggccuaug agcuguccac gcugacaggg      540

acacaggugc uguugcuggu ggccagugag acaggccaug uguauaccuu ugccacccga      600

aaacugcagc ccaugaucac cagugagacc ggcaaggcac ugauucagac cugccucaac      660

ucgccagacu cuccaccccg uucagacccc acaacagacc agagaaugag ugccacuggc      720

uuugaagaga cagaucucac cuaccaggug ucggagucug acagcagugg ggagaccaag      780

gacacacuga agccggcguu cacagucacc aaccugccgg guacaaccuc caccauccaa      840

acagcaccua gcaccucuac caccaugcaa gucagcagcg gccccuccuu ucccaucacc      900

aacuaccugg caccaguguc ugcuaguguc agccccagug cugucagcag ugccaauggg      960

acugugcuga agaguacagg cagcggcccu gucuccucug ggggccuuau gcagcugccu     1020

accagcuuca cccucaugcc ugguggggca guggcccagc aggucccagu gcaggccauu     1080

caagugcacc aggccccaca gcaagcgucu cccucccgug acagcagcac agaccucacg     1140

cagaccuccu ccagcgggac agugacgcug cccgccacca ucaugacguc auccgugccc     1200

acaacugugg guggccacau gauguacccu agcccgcaug cggugaugua ugcccccacc     1260

ucgggccugg gugauggcag ccucaccgug cugaaugccu ucucccaggc accauccacc     1320

augcaggugu cacacagcca gguccaggag ccagguggcg ucccccaggu guuccugaca     1380

gcaucaucug ggacagugca gaucccuguu ucagcaguuc agcuccacca gauggcugug     1440

auagggcagc aggccgggag cagcagcaac cucaccgagc uacagguggu gaaccuggac     1500

accgcccaca gcaccaagag ugaauga                                         1527


<210>  8600
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       FOS__Homo_sapiens__EAX04162

<400>  8600
augcugccca cccaggccgg cgccgcggcc gcccuggggc gcggcagcgc ccucgggggc       60

ucccugaacc ggaccccgac ggggcgcccc ggcggcgggg gcgggacccg gggcgccaac      120

gggggccgcg ugcccggcaa cggggcgggc cuggggcccg gccggcugga gcgcgaggcc      180

gccgccgcgg ccgccaccac cccggccccc acggccggcg cgcuguacag cggguccgag      240

ggcgacagcg aguccgggga ggaggaggag cucggcgccg agcggcgcgg gcugaagcgg      300

agccuguccg agauggagau cggcaugguc gugggcgggc ccgaggccag cgccgccgcg      360

accggcgggu acggccccgu guccggggcc gucagcggcg ccaagccggg caagaagacc      420

cgcgggcggg ugaagaucaa gauggaguuc aucgacaaca agcuccgccg guacaccacg      480

uucuccaagc gcaagaccgg caucaugaag aaggccuacg agcugagcac ccugaccggg      540

acccaggugc uccugcuggu cgccuccgag acgggccacg uguacaccuu cgcgacccgg      600

aagcuccagc ccaugaucac gagcgagacc gggaaggccc ugauccagac cugccugaac      660

ucccccgaca gcccgccccg cuccgacccc accacggacc agcggaugag cgccaccggc      720

uucgaggaga ccgaccucac cuaccaggug uccgagagcg acagcuccgg cgagacgaag      780

gacacccuga agcccgccuu caccgucacc aaccugcccg ggacgaccag caccauccag      840

accgccccgu ccacgagcac caccaugcag gucuccagcg gccccuccuu ccccaucacc      900

aacuaccucg cgcccgugag cgccuccgug agcccguccg ccgugagcuc cgccaacggg      960

acggugcuga aguccaccgg cuccggcccc gucagcuccg ggggccugau gcagcucccc     1020

accagcuuca cccugaugcc cgggggcgcg guggcccagc aggucccggu gcaggccauc     1080

caggugcacc aggcgcccca gcaggccucc cccagccgcg acagcuccac cgaccugacg     1140

cagaccagcu ccagcgggac cgugacccuc cccgccacga ucaugaccuc cagcgucccg     1200

accaccgugg gcggccacau gauguacccc agcccccacg ccgugaugua cgccccgacg     1260

agcgggcugg gcgacggguc ccugaccguc cucaacgccu ucagccaggc ccccuccacc     1320

augcagguca gccacuccca ggugcaggag cccggcgggg ugccccaggu guuccugacc     1380

gcgagcuccg gcacggucca gaucccggug agcgccgugc agcugcacca gauggccguc     1440

aucggccagc aggccggguc cagcagcaac cucaccgagc uccagguggu gaaccuggac     1500

accgcccacu ccaccaagag cgaguga                                         1527


<210>  8601
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       FOS__Homo_sapiens__EAX04162

<400>  8601
augcucccca cccaggccgg cgccgccgcc gcccucggcc gcggcuccgc ccucggcggc       60

ucccucaacc gcacccccac cggccgcccc ggcggcggcg gcggcacccg cggcgccaac      120

ggcggccgcg uccccggcaa cggcgccggc cucggccccg gccgccucga gcgcgaggcc      180

gccgccgccg ccgccaccac ccccgccccc accgccggcg cccucuacuc cggcuccgag      240

ggcgacuccg aguccggcga ggaggaggag cucggcgccg agcgccgcgg ccucaagcgc      300

ucccucuccg agauggagau cggcaugguc gucggcggcc ccgaggccuc cgccgccgcc      360

accggcggcu acggccccgu cuccggcgcc gucuccggcg ccaagcccgg caagaagacc      420

cgcggccgcg ucaagaucaa gauggaguuc aucgacaaca agcuccgccg cuacaccacc      480

uucuccaagc gcaagaccgg caucaugaag aaggccuacg agcucuccac ccucaccggc      540

acccaggucc uccuccucgu cgccuccgag accggccacg ucuacaccuu cgccacccgc      600

aagcuccagc ccaugaucac cuccgagacc ggcaaggccc ucauccagac cugccucaac      660

ucccccgacu cccccccccg cuccgacccc accaccgacc agcgcauguc cgccaccggc      720

uucgaggaga ccgaccucac cuaccagguc uccgaguccg acuccuccgg cgagaccaag      780

gacacccuca agcccgccuu caccgucacc aaccuccccg gcaccaccuc caccauccag      840

accgcccccu ccaccuccac caccaugcag gucuccuccg gccccuccuu ccccaucacc      900

aacuaccucg cccccgucuc cgccuccguc ucccccuccg ccgucuccuc cgccaacggc      960

accguccuca aguccaccgg cuccggcccc gucuccuccg gcggccucau gcagcucccc     1020

accuccuuca cccucaugcc cggcggcgcc gucgcccagc agguccccgu ccaggccauc     1080

cagguccacc aggcccccca gcaggccucc cccucccgcg acuccuccac cgaccucacc     1140

cagaccuccu ccuccggcac cgucacccuc cccgccacca ucaugaccuc cuccgucccc     1200

accaccgucg gcggccacau gauguacccc uccccccacg ccgucaugua cgcccccacc     1260

uccggccucg gcgacggcuc ccucaccguc cucaacgccu ucucccaggc ccccuccacc     1320

augcaggucu cccacuccca gguccaggag cccggcggcg ucccccaggu cuuccucacc     1380

gccuccuccg gcaccgucca gauccccguc uccgccgucc agcuccacca gauggccguc     1440

aucggccagc aggccggcuc cuccuccaac cucaccgagc uccaggucgu caaccucgac     1500

accgcccacu ccaccaaguc cgaguga                                         1527


<210>  8602
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       FOS__Homo_sapiens__EAX04162

<400>  8602
augcugccca cccaggccgg cgcugcagcc gcgcucggga gaggaagcgc ucuugguggc       60

ucccugaaca ggacaccuac ugggcggcca ggaggcggug ggggaacgcg cggcgccaau      120

ggcgggcgag ugccgggaaa cggugcaggc uuggggcccg gacguuuaga gagagaagcc      180

gcugcagccg cugccaccac uccugcgcca acugcaggcg cccuguacuc ugguucagag      240

ggggacagug aaagcggaga ggaagaggag cuaggcgcug aaaggcgggg ccucaagcgc      300

ucccugucug agauggaaau cgggaugguc guuggagguc ccgaggccuc ggcagcugcc      360

accggcgggu auggaccugu gucaggcgcg guaagcggug ccaaaccagg gaagaaaaca      420

agaggcaggg ugaagauuaa aauggaguuc auagauaaua aacuucggcg cuacaccacu      480

uuuaguaagc gaaaaacagg aaucaugaag aaagcauaug aacuguccac cuugacgggc      540

acucaagucc uccugcuggu ggcuucugag accgggcacg uuuacacauu cgccacuaga      600

aagcuccagc ccaugauuac cagcgaaaca ggaaaggcuu uaauccagac cugccugaac      660

uccccugacu caccaccgag gagugauccc acgacugacc agcggaugag cgccacaggu      720

uuugaggaaa ccgaucuuac uuaucaagug ucugaguccg acucaagcgg cgagacaaag      780

gauaccuuga agccugcauu cacggucacc aaucugccag ggacaacaag uaccauucag      840

acagcccccu cuacuuccac cacaaugcaa gugagcucgg gaccuucuuu uccaaucacc      900

aacuaccuag cucccguauc cgcgucaguu aguccgagcg caguguccuc ugccaauggc      960

acuguccuca aaagcacggg uucagggccu gugaguuccg gcggacugau gcagcuuccc     1020

acaucuuuca cccugaugcc aggcggggcu guggcccagc aggucccugu ucaggcaaua     1080

caggugcauc aagcucccca gcaggccucu ccaucacgug acaguagcac ugauuugacc     1140

caaacauccu cuucgggaac cguaacucuc cccgccacaa ucaugacgag cuccgugccu     1200

accacugucg guggccacau gauguaucca ucaccgcaug cagugaugua cgcgcccaca     1260

agugggcugg gagacggcuc uuuaaccguu cugaacgcuu uuagccaggc cccuuccaca     1320

augcaagugu cacacagcca gguccaggaa ccaggugggg ugccccaggu auuccucacu     1380

gcaucuuccg gcaccguuca gauuccugug agugccgucc agcuucauca aauggcugug     1440

aucggacagc aggccggcag cagcuccaau cugacggagu ugcaggucgu gaaccuagau     1500

accgcacacu caacaaagag ugaauga                                         1527


<210>  8603
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       FOS__Homo_sapiens__EAX04162

<400>  8603
augcugccca cccaggccgg cgccgccgcc gcccugggca gaggcagcgc ccugggcggc       60

agccugaaca gaacccccac cggcagaccc ggcggcggcg gcggcaccag aggcgccaac      120

ggcggcagag ugcccggcaa cggcgccggc cugggccccg gcagacugga gagagaggcc      180

gccgccgccg ccgccaccac ccccgccccc accgccggcg cccuguacag cggcagcgag      240

ggcgacagcg agagcggcga ggaggaggag cugggcgccg agagaagagg ccugaagaga      300

agccugagcg agauggagau cggcauggug gugggcggcc ccgaggccag cgccgccgcc      360

accggcggcu acggccccgu gagcggcgcc gugagcggcg ccaagcccgg caagaagacc      420

agaggcagag ugaagaucaa gauggaguuc aucgacaaca agcugagaag auacaccacc      480

uucagcaaga gaaagaccgg caucaugaag aaggccuacg agcugagcac ccugaccggc      540

acccaggugc ugcugcuggu ggccagcgag accggccacg uguacaccuu cgccaccaga      600

aagcugcagc ccaugaucac cagcgagacc ggcaaggccc ugauccagac cugccugaac      660

agccccgaca gcccccccag aagcgacccc accaccgacc agagaaugag cgccaccggc      720

uucgaggaga ccgaccugac cuaccaggug agcgagagcg acagcagcgg cgagaccaag      780

gacacccuga agcccgccuu caccgugacc aaccugcccg gcaccaccag caccauccag      840

accgccccca gcaccagcac caccaugcag gugagcagcg gccccagcuu ccccaucacc      900

aacuaccugg cccccgugag cgccagcgug agccccagcg ccgugagcag cgccaacggc      960

accgugcuga agagcaccgg cagcggcccc gugagcagcg gcggccugau gcagcugccc     1020

accagcuuca cccugaugcc cggcggcgcc guggcccagc aggugcccgu gcaggccauc     1080

caggugcacc aggcccccca gcaggccagc cccagcagag acagcagcac cgaccugacc     1140

cagaccagca gcagcggcac cgugacccug cccgccacca ucaugaccag cagcgugccc     1200

accaccgugg gcggccacau gauguacccc agcccccacg ccgugaugua cgcccccacc     1260

agcggccugg gcgacggcag ccugaccgug cugaacgccu ucagccaggc ccccagcacc     1320

augcagguga gccacagcca ggugcaggag cccggcggcg ugccccaggu guuccugacc     1380

gccagcagcg gcaccgugca gauccccgug agcgccgugc agcugcacca gauggccgug     1440

aucggccagc aggccggcag cagcagcaac cugaccgagc ugcagguggu gaaccuggac     1500

accgcccaca gcaccaagag cgaguga                                         1527


<210>  8604
<211>  1527
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       FOS__Homo_sapiens__EAX04162

<400>  8604
augcugccca cccaggccgg cgcugccgcg gcucucggga gaggaagcgc ccugggcggg       60

ucccuuaacc ggacaccuac gggacgcccg ggcgggggag gcggcaccag aggggccaau      120

ggaggccggg ugcccgggaa cggagcuggc cuggggccug gacgccucga gagagaagcc      180

gcugccgcgg ccgcuacaac ccccgccccu acagcuggcg cccuguacuc uggcagcgag      240

ggggacuccg aaucuggaga ggaagaggag cuuggcgcgg aacggcgcgg gcugaagaga      300

agccucuccg agauggaaau cggaaugguc guuggcgggc ccgaggccuc ugcugccgcu      360

accggaggcu auggcccugu gagcggggcc guguccggag ccaaaccggg caagaaaaca      420

cgggggcgcg ucaagauuaa aauggaguuc aucgauaaua agcugagacg guacaccacg      480

uuuagcaagc gcaaaaccgg aauuaugaag aaggcuuaug aacugucuac acucaccggc      540

acacaagugc ugcuucuggu ugcguccgag accgggcacg uguacacguu cgccacaaga      600

aaacuccagc ccaugaucac cagcgaaaca ggcaaagcuc ugauucagac cugccuuaac      660

ucuccugaca gcccgccucg gagcgauccc accacagacc agcgcauguc ugccacggga      720

uuugaggaaa ccgaucugac auaucaaguc uccgagagcg acuccucugg cgagaccaag      780

gauacacuca agccggccuu caccgugacg aaucugccug ggacaaccag caccauccag      840

acagcucccu ccaccagcac aacgaugcag guuucuuccg gaccuagcuu ucccaucacc      900

aacuaccugg cccccguguc ugcgagcguc uccccuucug cugugagcuc cgccaauggc      960

acagugcuca aaagcaccgg gucuggaccg gucuccagcg gcgggcugau gcagcuuccc     1020

acaucuuuca cccugaugcc uggcggagcc guugcucaac aggugcccgu gcaggccauu     1080

cagguccauc aagcuccuca gcaggccucc cccagcagag acuccucuac ggaucucacc     1140

caaacaagcu ccucuggcac cgugacacug ccggcgacca ucaugacgag cuccguuccu     1200

acaaccgucg ggggacacau gauguauccc agcccucaug ccgugaugua cgcucccaca     1260

ucuggccuug gggacggauc ccugaccgug cucaacgccu uuagccaggc uccuucuacc     1320

augcagguuu cccacagcca ggugcaagaa cccggcgggg ucccccaggu guuccugaca     1380

gccucuagcg gcacggucca gauuccugug uccgcgguuc agcugcauca aauggccgug     1440

aucggacagc aggcuggcuc cucuuccaau cucaccgagc ugcaggucgu gaaccuugau     1500

acagcccaca gcaccaaguc cgaauga                                         1527


<210>  8605
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSK3A__Homo_sapiens__P49840

<400>  8605

Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210>  8606
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GSK3A__Homo_sapiens__CCDS12599.1

<400>  8606
augagcggcg gcgggccuuc gggaggcggc ccugggggcu cgggcagggc gcggacuagc       60

ucguucgcgg agcccggcgg cggaggcgga ggaggcggcg gcggccccgg aggcucggcc      120

uccggcccag gcggcaccgg cggcggaaag gcaucugucg gggccauggg ugggggcguc      180

ggggccucga gcuccggggg uggacccggc ggcagcggcg gaggaggcag cggaggcccc      240

ggcgcaggca cuagcuuccc gccgcccggg gugaagcugg gccgugacag cgggaaggug      300

accacagucg uagccacucu aggccaaggc ccagagcgcu cccaagaagu ggcuuacacg      360

gacaucaaag ugauuggcaa uggcucauuu ggggucgugu accaggcacg gcuggcagag      420

accagggaac uagucgccau caagaagguu cuccaggaca agagguucaa gaaccgagag      480

cugcagauca ugcguaagcu ggaccacugc aauauuguga ggcugagaua cuuuuucuac      540

uccaguggcg agaagaaaga cgagcuuuac cuaaaucugg ugcuggaaua ugugcccgag      600

acaguguacc ggguggcccg ccacuucacc aaggccaagu ugaccauccc uauccucuau      660

gucaaggugu acauguacca gcucuuccgc agcuuggccu acauccacuc ccagggcgug      720

ugucaccgcg acaucaagcc ccagaaccug cugguggacc cugacacugc uguccucaag      780

cucugcgauu uuggcagugc aaagcaguug guccgagggg agcccaaugu cuccuacauc      840

uguucucgcu acuaccgggc cccagagcuc aucuuuggag ccacugauua caccucaucc      900

aucgauguuu ggucagcugg cuguguacug gcagagcucc ucuugggcca gcccaucuuc      960

ccuggggaca guggggugga ccagcuggug gagaucauca aggugcuggg aacaccaacc     1020

cgggaacaaa uccgagagau gaaccccaac uacacggagu ucaaguuccc ucagauuaaa     1080

gcucaccccu ggacaaaggu guucaaaucu cgaacgccgc cagaggccau cgcgcucugc     1140

ucuagccugc uggaguacac cccauccuca aggcucuccc cacuagaggc cugugcgcac     1200

agcuucuuug augaacugcg augucuggga acccagcugc cuaacaaccg cccacuuccc     1260

ccucucuuca acuucagugc uggugaacuc uccauccaac cgucucucaa cgccauucuc     1320

aucccuccuc acuugagguc cccagcgggc acuaccaccc ucaccccguc cucacaagcu     1380

uuaacugaga cuccgaccag cucagacugg cagucgaccg augccacacc uacccucacu     1440

aacuccuccu ga                                                         1452


<210>  8607
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GSK3A__Homo_sapiens__CCDS12599.1

<400>  8607
augagcggcg ggggccccuc cgggggcggg ccgggcggca gcgggcgcgc ccggaccucc       60

agcuucgccg agcccggcgg gggcgggggc ggcgggggcg ggggccccgg cggguccgcg      120

agcggccccg ggggcaccgg gggcggcaag gccuccgugg gggccauggg cgggggcguc      180

ggggccagcu ccagcggcgg cgggccgggc ggguccggcg ggggcggcag cgggggcccc      240

ggggccggca cguccuuccc gccgcccggc gugaagcugg ggcgcgacag cggcaaggug      300

accaccgucg uggcgacccu cgggcagggc cccgagcggu cccaggaggu ggccuacacg      360

gacaucaagg ucaucgggaa cggcagcuuc ggcguggugu accaggcccg ccuggccgag      420

acccgggagc uggucgcgau caagaaggug cuccaggaca agcgcuucaa gaaccgggag      480

cugcagauca ugcgcaagcu ggaccacugc aacaucgugc ggcuccgcua cuucuucuac      540

uccagcgggg agaagaagga cgagcuguac cugaaccucg uccuggagua cgugcccgag      600

accguguacc gggucgcccg ccacuucacc aaggccaagc ugacgauccc cauccucuac      660

gugaaggugu acauguacca gcuguuccgg ucccuggccu acauccacag ccagggcguc      720

ugccaccgcg acaucaagcc ccagaaccuc cugguggacc ccgacaccgc cgugcugaag      780

cucugcgacu ucgggagcgc gaagcagcug guccggggcg agcccaacgu guccuacauc      840

ugcagccgcu acuaccgggc ccccgagcug aucuucgggg ccaccgacua caccuccagc      900

aucgacgugu gguccgccgg cugcguccuc gccgagcugc ugcucggcca gccgaucuuc      960

cccggggaca gcggcgugga ccagcugguc gagaucauca aggugcuggg gacgcccacc     1020

cgcgagcaga uccgggagau gaaccccaac uacaccgagu ucaaguuccc gcagaucaag     1080

gcgcaccccu ggaccaaggu guucaagucc cgcacgccgc ccgaggccau cgcccucugc     1140

agcucccugc uggaguacac ccccagcucc cggcucagcc cccuggaggc cugcgcccac     1200

uccuucuucg acgagcugcg cugccucggc acccagcugc ccaacaaccg cccccugccg     1260

ccccucuuca acuucagcgc gggggagcug uccauccagc ccagccugaa cgccauccuc     1320

aucccgcccc accuccgguc ccccgccggc accacgaccc ugacccccag cucccaggcc     1380

cugaccgaga cgccgaccag cagcgacugg caguccaccg acgccacccc cacgcugacc     1440

aacagcuccu ga                                                         1452


<210>  8608
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GSK3A__Homo_sapiens__CCDS12599.1

<400>  8608
auguccggcg gcggccccuc cggcggcggc cccggcggcu ccggccgcgc ccgcaccucc       60

uccuucgccg agcccggcgg cggcggcggc ggcggcggcg gcggccccgg cggcuccgcc      120

uccggccccg gcggcaccgg cggcggcaag gccuccgucg gcgccauggg cggcggcguc      180

ggcgccuccu ccuccggcgg cggccccggc ggcuccggcg gcggcggcuc cggcggcccc      240

ggcgccggca ccuccuuccc cccccccggc gucaagcucg gccgcgacuc cggcaagguc      300

accaccgucg ucgccacccu cggccagggc cccgagcgcu cccaggaggu cgccuacacc      360

gacaucaagg ucaucggcaa cggcuccuuc ggcgucgucu accaggcccg ccucgccgag      420

acccgcgagc ucgucgccau caagaagguc cuccaggaca agcgcuucaa gaaccgcgag      480

cuccagauca ugcgcaagcu cgaccacugc aacaucgucc gccuccgcua cuucuucuac      540

uccuccggcg agaagaagga cgagcucuac cucaaccucg uccucgagua cguccccgag      600

accgucuacc gcgucgcccg ccacuucacc aaggccaagc ucaccauccc cauccucuac      660

gucaaggucu acauguacca gcucuuccgc ucccucgccu acauccacuc ccagggcguc      720

ugccaccgcg acaucaagcc ccagaaccuc cucgucgacc ccgacaccgc cguccucaag      780

cucugcgacu ucggcuccgc caagcagcuc guccgcggcg agcccaacgu cuccuacauc      840

ugcucccgcu acuaccgcgc ccccgagcuc aucuucggcg ccaccgacua caccuccucc      900

aucgacgucu gguccgccgg cugcguccuc gccgagcucc uccucggcca gcccaucuuc      960

cccggcgacu ccggcgucga ccagcucguc gagaucauca agguccucgg cacccccacc     1020

cgcgagcaga uccgcgagau gaaccccaac uacaccgagu ucaaguuccc ccagaucaag     1080

gcccaccccu ggaccaaggu cuucaagucc cgcacccccc ccgaggccau cgcccucugc     1140

uccucccucc ucgaguacac ccccuccucc cgccucuccc cccucgaggc cugcgcccac     1200

uccuucuucg acgagcuccg cugccucggc acccagcucc ccaacaaccg cccccucccc     1260

ccccucuuca acuucuccgc cggcgagcuc uccauccagc ccucccucaa cgccauccuc     1320

aucccccccc accuccgcuc ccccgccggc accaccaccc ucacccccuc cucccaggcc     1380

cucaccgaga cccccaccuc cuccgacugg caguccaccg acgccacccc cacccucacc     1440

aacuccuccu ga                                                         1452


<210>  8609
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GSK3A__Homo_sapiens__CCDS12599.1

<400>  8609
augagcggcg ggggacccuc cgguggcggg ccuggaggcu cugguagagc caggaccuca       60

aguuucgcug agccaggggg aggcggcggg ggagguggcg ggggaccggg cgguagcgca      120

uccgggcccg gaggcacagg cgggggaaag gccucugugg gugcgauggg cgggggaguc      180

ggcgcuucgu caagcggugg gggcccugga ggcagugggg gagguggcuc cgggggacca      240

ggcgccggua cuucuuuucc cccuccaggg guuaaacugg gccgggacag cggaaaggug      300

acgaccguag uggcaacacu cggccagggg cccgaacgcu cccaagaggu cgccuacacu      360

gauaucaaag ugauuggaaa cgguucauuc ggcguugugu aucaggcucg acuugcagaa      420

acccgugagc uggucgccau aaagaaagug uugcaggaca agagauuuaa gaauagggaa      480

uuacagauca ugcggaaacu ggaucacugc aacauuguac gccuaagaua cuucuuuuau      540

aguagcgggg agaagaaaga cgagcucuac cugaaucuug uucuggaaua ugugccugag      600

acagucuaca ggguggcucg gcacuucacc aaggccaaau ugacuauccc aauucucuau      660

gugaaggucu acauguacca acuguuucgc ucucuggcgu auauccacuc ccagggaguu      720

ugucaucgag auauaaagcc gcagaaccuc uuaguggacc ccgauacagc aguacugaaa      780

cuuugcgacu ucggcucagc caagcaguug gugagaggug aaccuaaugu cagcuacauc      840

uguaguaggu auuaccgggc uccagagcug auuuuugggg ccaccgauua uacgucuucc      900

aucgacgugu ggagcgcagg cugcguucua gcugagcucc ugcuuggaca acccauuuuc      960

ccuggcgauu cgggggugga ccagcugguc gaaaucauaa aaguguuggg aacuccaacc     1020

cgugagcaga uucgcgaaau gaaccccaau uacacagagu uuaaguuccc gcagaucaaa     1080

gcccacccuu ggacuaaggu auuuaaaucu agaacacccc cagaagcgau ugcccucugu     1140

uccucacugu uagaguauac cccuaguagc aggcugucuc cccucgaggc augcgcucau     1200

uccuucuucg augaacuucg gugucugggc acccaauugc caaacaaucg accccuaccu     1260

ccacuguuua acuucagcgc cggugagcuc ucaauccagc cgagucugaa ugcuauccuu     1320

auucccccuc aucugcgcuc cccagccggg acgacuacau ugacccccag cucucaggca     1380

cucacugaaa caccuaccuc aagugacugg caaagcacgg acgccacccc aacacugacu     1440

aacuccucuu ga                                                         1452


<210>  8610
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GSK3A__Homo_sapiens__CCDS12599.1

<400>  8610
augagcggcg gcggccccag cggcggcggc cccggcggca gcggcagagc cagaaccagc       60

agcuucgccg agcccggcgg cggcggcggc ggcggcggcg gcggccccgg cggcagcgcc      120

agcggccccg gcggcaccgg cggcggcaag gccagcgugg gcgccauggg cggcggcgug      180

ggcgccagca gcagcggcgg cggccccggc ggcagcggcg gcggcggcag cggcggcccc      240

ggcgccggca ccagcuuccc cccccccggc gugaagcugg gcagagacag cggcaaggug      300

accaccgugg uggccacccu gggccagggc cccgagagaa gccaggaggu ggccuacacc      360

gacaucaagg ugaucggcaa cggcagcuuc ggcguggugu accaggccag acuggccgag      420

accagagagc ugguggccau caagaaggug cugcaggaca agagauucaa gaacagagag      480

cugcagauca ugagaaagcu ggaccacugc aacaucguga gacugagaua cuucuucuac      540

agcagcggcg agaagaagga cgagcuguac cugaaccugg ugcuggagua cgugcccgag      600

accguguaca gaguggccag acacuucacc aaggccaagc ugaccauccc cauccuguac      660

gugaaggugu acauguacca gcuguucaga agccuggccu acauccacag ccagggcgug      720

ugccacagag acaucaagcc ccagaaccug cugguggacc ccgacaccgc cgugcugaag      780

cugugcgacu ucggcagcgc caagcagcug gugagaggcg agcccaacgu gagcuacauc      840

ugcagcagau acuacagagc ccccgagcug aucuucggcg ccaccgacua caccagcagc      900

aucgacgugu ggagcgccgg cugcgugcug gccgagcugc ugcugggcca gcccaucuuc      960

cccggcgaca gcggcgugga ccagcuggug gagaucauca aggugcuggg cacccccacc     1020

agagagcaga ucagagagau gaaccccaac uacaccgagu ucaaguuccc ccagaucaag     1080

gcccaccccu ggaccaaggu guucaagagc agaacccccc ccgaggccau cgcccugugc     1140

agcagccugc uggaguacac ccccagcagc agacugagcc cccuggaggc cugcgcccac     1200

agcuucuucg acgagcugag augccugggc acccagcugc ccaacaacag accccugccc     1260

ccccuguuca acuucagcgc cggcgagcug agcauccagc ccagccugaa cgccauccug     1320

aucccccccc accugagaag ccccgccggc accaccaccc ugacccccag cagccaggcc     1380

cugaccgaga cccccaccag cagcgacugg cagagcaccg acgccacccc cacccugacc     1440

aacagcagcu ga                                                         1452


<210>  8611
<211>  1452
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GSK3A__Homo_sapiens__CCDS12599.1

<400>  8611
augagcggcg ggggacccuc cggcggggga ccuggcgggu cuggacgcgc ccggaccagc       60

uccuucgcug agccgggcgg cgggggaggc gggggaggcg ggggacccgg cggcucugcc      120

agcgggccug gaggcacagg gggaggcaag gcguccgugg gggcuauggg aggcggcguc      180

ggggccucua gcuccggagg cgggcccgga ggcagcgggg gcggaggcuc ugggggaccu      240

ggcgccggga cguccuuucc cccuccggga guuaaacugg gccgcgacag cgggaaggug      300

accacagugg ucgcuacccu cggccaggga cccgaaagau cucaagaggu ggccuacaca      360

gauaucaaag uuaucggcaa cggguccuuc ggaguggucu aucaggcucg gcuggccgaa      420

acccgcgagc uuguggcgau caagaaaguu cugcaggaca agagauuuaa gaaucgggaa      480

cuccagauua ugcgcaaacu ggaucacugc aacaucguga gacuucggua cuucuuuuau      540

agcucuggcg agaagaaaga cgagcuguac cucaaucugg uccuggaaua ugugccugag      600

acaguguacc gcgucgccag acauuucacc aaggcuaaac ucacgauucc cauccuguau      660

guuaaggugu acauguacca acuuuuucgg ucccuggccu auauccacag ccagggggug      720

ugucaucgcg auauuaagcc ucagaaccuc cuggucgacc ccgauaccgc ugugcuuaaa      780

cugugcgacu ucggauccgc caagcagcuc guuagaggcg aaccgaaugu gucuuacauc      840

uguagccggu auuaccgcgc gccugagcug auuuuugggg ccacagauua uaccuccagc      900

aucgacgucu ggucugcugg cugcgugcug gccgagcucc ugcuuggaca acccauuuuc      960

ccuggcgauu ccgggguuga ccagcuggug gaaaucauua aaguccucgg aacacccacc     1020

agagagcaga uccgggaaau gaaccccaau uacacggagu uuaaguuccc ucagaucaaa     1080

gcucacccgu ggacaaaggu guuuaaaagc agaacacccc cugaagccau ugcccugugu     1140

ucuagccuuc uggaguauac ccccuccucu cgccucagcc cucuggaggc uugcgcgcau     1200

uccuucuucg augaacugcg gugucucggc acccaacugc ccaacaauag accgcuuccu     1260

ccccuguuua acuucagcgc cggggagcuc ucuauccagc cuucccugaa ugcuauucuu     1320

auucccccuc accugagaag ccccgccgga accacaacgc ucaccccguc uucccaggcc     1380

cugacagaaa ccccuacaag cuccgacugg caaucuaccg acgcuacgcc cacacugacc     1440

aacagcuccu ga                                                         1452


<210>  8612
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSK3B__Homo_sapiens__P49841

<400>  8612

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  8613
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  GSK3B__Homo_sapiens__AAH12760

<400>  8613
augucagggc ggcccagaac caccuccuuu gcggagagcu gcaagccggu gcagcagccu       60

ucagcuuuug gcagcaugaa aguuagcaga gacaaggacg gcagcaaggu gacaacagug      120

guggcaacuc cugggcaggg uccagacagg ccacaagaag ucagcuauac agacacuaaa      180

gugauuggaa auggaucauu ugguguggua uaucaagcca aacuuuguga uucaggagaa      240

cuggucgcca ucaagaaagu auugcaggac aagagauuua agaaucgaga gcuccagauc      300

augagaaagc uagaucacug uaacauaguc cgauugcguu auuucuucua cuccaguggu      360

gagaagaaag augaggucua ucuuaaucug gugcuggacu auguuccgga aacaguauac      420

agaguugcca gacacuauag ucgagccaaa cagacgcucc cugugauuua ugucaaguug      480

uauauguauc agcuguuccg aaguuuagcc uauauccauu ccuuuggaau cugccaucgg      540

gauauuaaac cgcagaaccu cuuguuggau ccugauacug cuguauuaaa acucugugac      600

uuuggaagug caaagcagcu gguccgagga gaacccaaug uuucguauau cuguucucgg      660

uacuauaggg caccagaguu gaucuuugga gccacugauu auaccucuag uauagaugua      720

uggucugcug gcuguguguu ggcugagcug uuacuaggac aaccaauauu uccaggggau      780

aguggugugg aucaguuggu agaaauaauc aagguccugg gaacuccaac aagggagcaa      840

aucagagaaa ugaacccaaa cuacacagaa uuuaaauucc cucaaauuaa ggcacauccu      900

uggacuaagg ucuuccgacc ccgaacucca ccggaggcaa uugcacugug uagccgucug      960

cuggaguaua caccaacugc ccgacuaaca ccacuggaag cuugugcaca uucauuuuuu     1020

gaugaauuac gggacccaaa ugucaaacua ccaaaugggc gagacacacc ugcacucuuc     1080

aacuucacca cucaagaacu gucaaguaau ccaccucugg cuaccauccu uauuccuccu     1140

caugcucgga uucaagcagc ugcuucaacc cccacaaaug ccacagcagc gucagaugcu     1200

aauacuggag accguggaca gaccaauaau gcugcuucug caucagcuuc caacuccacc     1260

uga                                                                   1263


<210>  8614
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       GSK3B__Homo_sapiens__AAH12760

<400>  8614
augagcggcc gcccccggac caccuccuuc gccgagagcu gcaagcccgu gcagcagccc       60

uccgccuucg ggagcaugaa ggucucccgc gacaaggacg gcagcaaggu gacgaccgug      120

gucgcgaccc ccgggcaggg ccccgaccgg ccgcaggagg uguccuacac cgacacgaag      180

gugaucggga acggcagcuu cggcgucgug uaccaggcca agcugugcga cuccggggag      240

cucguggcca ucaagaaggu ccugcaggac aagcgcuuca agaaccggga gcugcagauc      300

augcgcaagc ucgaccacug caacaucgug cggcugcgcu acuucuucua cagcuccggc      360

gagaagaagg acgaggugua ccugaaccuc guccuggacu acgugcccga gaccguguac      420

cgggucgccc gccacuacag ccgggccaag cagacccugc ccgugaucua cgugaagcuc      480

uacauguacc agcuguuccg cucccuggcg uacauccaca gcuucgggau cugccaccgg      540

gacaucaagc cccagaaccu ccugcuggac ccggacaccg ccguccucaa gcugugcgac      600

uucggcuccg ccaagcagcu ggugcgcggg gagcccaacg ugagcuacau cugcucccgg      660

uacuaccgcg cccccgagcu caucuucggc gcgacggacu acaccagcuc caucgacguc      720

uggagcgccg gcugcgugcu ggccgagcug cuccuggggc agcccaucuu cccgggcgac      780

agcggggugg accagcuggu cgagaucauc aaggugcucg gcacccccac ccgggagcag      840

auccgcgaga ugaaccccaa cuacacggag uucaaguucc cccagaucaa ggcccacccg      900

uggaccaagg ucuuccggcc ccgcaccccg cccgaggcca ucgcgcugug cucccggcug      960

cucgaguaca cccccacggc ccgccugacg ccccuggagg ccugcgccca cagcuucuuc     1020

gacgagcucc gcgaccccaa cgugaagcug cccaacggcc gggacacccc ggcccuguuc     1080

aacuucacca cccaggagcu cuccagcaac ccgccccugg cgaccauccu gaucccgccc     1140

cacgcccgca uccaggccgc cgccuccacc cccaccaacg cgacggccgc cagcgacgcc     1200

aacaccgggg accggggcca gaccaacaac gccgcguccg ccagcgccuc caacagcacc     1260

uga                                                                   1263


<210>  8615
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       GSK3B__Homo_sapiens__AAH12760

<400>  8615
auguccggcc gcccccgcac caccuccuuc gccgaguccu gcaagcccgu ccagcagccc       60

uccgccuucg gcuccaugaa ggucucccgc gacaaggacg gcuccaaggu caccaccguc      120

gucgccaccc ccggccaggg ccccgaccgc ccccaggagg ucuccuacac cgacaccaag      180

gucaucggca acggcuccuu cggcgucguc uaccaggcca agcucugcga cuccggcgag      240

cucgucgcca ucaagaaggu ccuccaggac aagcgcuuca agaaccgcga gcuccagauc      300

augcgcaagc ucgaccacug caacaucguc cgccuccgcu acuucuucua cuccuccggc      360

gagaagaagg acgaggucua ccucaaccuc guccucgacu acguccccga gaccgucuac      420

cgcgucgccc gccacuacuc ccgcgccaag cagacccucc ccgucaucua cgucaagcuc      480

uacauguacc agcucuuccg cucccucgcc uacauccacu ccuucggcau cugccaccgc      540

gacaucaagc cccagaaccu ccuccucgac cccgacaccg ccguccucaa gcucugcgac      600

uucggcuccg ccaagcagcu cguccgcggc gagcccaacg ucuccuacau cugcucccgc      660

uacuaccgcg cccccgagcu caucuucggc gccaccgacu acaccuccuc caucgacguc      720

ugguccgccg gcugcguccu cgccgagcuc cuccucggcc agcccaucuu ccccggcgac      780

uccggcgucg accagcucgu cgagaucauc aagguccucg gcacccccac ccgcgagcag      840

auccgcgaga ugaaccccaa cuacaccgag uucaaguucc cccagaucaa ggcccacccc      900

uggaccaagg ucuuccgccc ccgcaccccc cccgaggcca ucgcccucug cucccgccuc      960

cucgaguaca cccccaccgc ccgccucacc ccccucgagg ccugcgccca cuccuucuuc     1020

gacgagcucc gcgaccccaa cgucaagcuc cccaacggcc gcgacacccc cgcccucuuc     1080

aacuucacca cccaggagcu cuccuccaac cccccccucg ccaccauccu cauccccccc     1140

cacgcccgca uccaggccgc cgccuccacc cccaccaacg ccaccgccgc cuccgacgcc     1200

aacaccggcg accgcggcca gaccaacaac gccgccuccg ccuccgccuc caacuccacc     1260

uga                                                                   1263


<210>  8616
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       GSK3B__Homo_sapiens__AAH12760

<400>  8616
augagcggca gacccaggac cacauccuuc gccgagucuu gcaagccugu gcagcaacca       60

ucagcuuuug ggaguaugaa agucagccgg gacaaggaug gauccaaagu uacuacggug      120

guagcaaccc cgggucaggg ccccgaccgc ccucaggaag ugucuuacac agauacuaag      180

gucaucggga acggaucguu cggcgugguu uaucaggcca aacuguguga cucaggugag      240

cucguggcga ucaagaaggu ccuucaagau aaacgauuua agaaucguga acugcagaua      300

augagaaaau uggaccacug caacaucgug agguuacggu acuucuuuua uagcaguggg      360

gagaagaaag augaaguaua ccugaaucua guucucgacu augugccaga gaccgucuac      420

cgcguggcua gacauuauuc cagggccaag cagacacugc ccgugauuua cgucaaacuu      480

uacauguauc agcuguuccg gucuuuggca uacauccaca gcuuuggaau uugucaucgc      540

gauaucaagc cucaaaaccu ccugcuggac ccagauaccg ccguucucaa guuaugcgac      600

uucggcuccg cuaaacagcu ggugcgaggc gagcccaaug uaucauauau auguaguaga      660

uacuauaggg caccugaacu uaucuuuggg gccacugauu acacaagcuc uauugacgug      720

ugguccgcug gaugcgucuu ggccgagcug cuacucgguc agccaaucuu cccgggcgac      780

ucaggggugg aucagcuggu ugaaauuauc aaggugcuug gaacccccac gcgggagcaa      840

auacgugaga ugaacccuaa uuauacugaa uuuaaauucc cacagauuaa ggcgcacccc      900

uggaccaaag ucuuucgccc uagaacacca cccgaggcaa ucgcccugug uagcagguug      960

cucgaauaca cuccgaccgc ucggcugaca ccuuuagagg ccugcgcaca uaguuucuuc     1020

gacgaacugc gagaucccaa cgugaagcuc ccaaauggcc gcgacacccc ugcucuuuuu     1080

aacuucacga cucaggagcu gucuuccaau cccccauugg ccacaauucu aauucccccu     1140

cacgcgagaa uccaagccgc agcuagcacc ccaacuaacg ccacagcugc cucggaugca     1200

aauaccggug acagggggca gacgaacaau gccgcuucug cguccgcauc aaacaguacc     1260

uga                                                                   1263


<210>  8617
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       GSK3B__Homo_sapiens__AAH12760

<400>  8617
augagcggca gacccagaac caccagcuuc gccgagagcu gcaagcccgu gcagcagccc       60

agcgccuucg gcagcaugaa ggugagcaga gacaaggacg gcagcaaggu gaccaccgug      120

guggccaccc ccggccaggg ccccgacaga ccccaggagg ugagcuacac cgacaccaag      180

gugaucggca acggcagcuu cggcguggug uaccaggcca agcugugcga cagcggcgag      240

cugguggcca ucaagaaggu gcugcaggac aagagauuca agaacagaga gcugcagauc      300

augagaaagc uggaccacug caacaucgug agacugagau acuucuucua cagcagcggc      360

gagaagaagg acgaggugua ccugaaccug gugcuggacu acgugcccga gaccguguac      420

agaguggcca gacacuacag cagagccaag cagacccugc ccgugaucua cgugaagcug      480

uacauguacc agcuguucag aagccuggcc uacauccaca gcuucggcau cugccacaga      540

gacaucaagc cccagaaccu gcugcuggac cccgacaccg ccgugcugaa gcugugcgac      600

uucggcagcg ccaagcagcu ggugagaggc gagcccaacg ugagcuacau cugcagcaga      660

uacuacagag cccccgagcu gaucuucggc gccaccgacu acaccagcag caucgacgug      720

uggagcgccg gcugcgugcu ggccgagcug cugcugggcc agcccaucuu ccccggcgac      780

agcggcgugg accagcuggu ggagaucauc aaggugcugg gcacccccac cagagagcag      840

aucagagaga ugaaccccaa cuacaccgag uucaaguucc cccagaucaa ggcccacccc      900

uggaccaagg uguucagacc cagaaccccc cccgaggcca ucgcccugug cagcagacug      960

cuggaguaca cccccaccgc cagacugacc ccccuggagg ccugcgccca cagcuucuuc     1020

gacgagcuga gagaccccaa cgugaagcug cccaacggca gagacacccc cgcccuguuc     1080

aacuucacca cccaggagcu gagcagcaac cccccccugg ccaccauccu gauccccccc     1140

cacgccagaa uccaggccgc cgccagcacc cccaccaacg ccaccgccgc cagcgacgcc     1200

aacaccggcg acagaggcca gaccaacaac gccgccagcg ccagcgccag caacagcacc     1260

uga                                                                   1263


<210>  8618
<211>  1263
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       GSK3B__Homo_sapiens__AAH12760

<400>  8618
augagcggca gaccccggac cacauccuuc gccgagucuu gcaagccugu gcagcaaccg       60

agcgcuuuug gguccaugaa agucucucgc gacaaggaug gaagcaaagu uacgaccgug      120

guggccacac ccggccaggg gccugacaga ccccaggaag ucuccuacac cgauacaaag      180

gugaucggaa acggcucuuu cgggguugug uaucaggcga aacuguguga cagcggagag      240

cucgucgcua uuaagaaggu gcugcaagau aaacgguuua agaaucgcga acuucagauc      300

augagaaaac uggaccacug caacauuguu cggcuccgcu acuucuuuua uuccagcggc      360

gagaagaaag augaagugua ccugaaucuu guccuggacu augugccuga gaccguguac      420

agagucgccc ggcauuauuc ucgcgccaag cagacacucc ccguuaucua cgugaagcug      480

uacauguauc agcuguucag aucccucgcu uacauucaca gcuuuggcau cugucaucgg      540

gauaucaaac cucaaaaccu gcuucuggac ccggauaccg ccgugcucaa gcugugcgac      600

uucgggucug cuaaacagcu uguccgcgga gagcccaaug uguccuauau uuguagcaga      660

uacuaucggg ccccugaacu gaucuuuggc gcgacggauu acaccucuuc cauugacguu      720

uggagcgccg ggugcgugcu cgcugagcug cugcucggac agcccaucuu cccuggcgac      780

uccggggucg aucagcuggu ggaaauuauc aagguucuug gaacacccac ccgcgagcaa      840

auuagagaga ugaacccgaa uuauacagaa uuuaaauucc cucagaucaa ggcccacccc      900

uggaccaaag uguuucggcc uagaacgccu cccgaggcua ucgcccugug uucucgccuc      960

cuggaauaca cacccaccgc gcggcuuaca ccgcuggagg ccugcgcuca uagcuucuuc     1020

gacgaacuca gagaucccaa cgucaagcug ccuaauggcc gcgacacccc cgcccuguuu     1080

aacuucacca cacaggagcu cuccagcaau ccuccccugg cuacgauucu uaucccgccu     1140

cacgcccgga uucaagccgc ugcgucuacc cccacaaacg ccaccgcugc cuccgaugcc     1200

aauacaggcg acagagggca gaccaacaau gcugccagcg cgucugcuag caacuccacg     1260

uga                                                                   1263


<210>  8619
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP10__Homo_sapiens__P61604

<400>  8619

Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val 
1               5                   10                  15      


Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met 
            20                  25                  30          


Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala 
        35                  40                  45              


Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser 
    50                  55                  60                  


Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys 
65                  70                  75                  80  


Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile 
                85                  90                  95      


Leu Gly Lys Tyr Val Asp 
            100         


<210>  8620
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP10__Homo_sapiens__AAA50953

<400>  8620
auggcaggac aagcguuuag aaaguuucuu ccacucuuug accgaguauu gguugaaagg       60

agugcugcug aaacuguaac caaaggaggc auuaugcuuc cagaaaaauc ucaaggaaaa      120

guauugcaag caacaguagu cgcuguugga ucggguucua aaggaaaggg uggagagauu      180

caaccaguua gcgugaaagu uggagauaaa guucuucucc cagaauaugg aggcaccaaa      240

guaguucuag augacaagga uuauuuccua uuuagagaug gugacauucu uggaaaguac      300

guagacuga                                                              309


<210>  8621
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP10__Homo_sapiens__AAA50953

<400>  8621
auggccggcc aggccuuccg caaguuccug ccccucuucg accgggugcu ggucgagcgc       60

agcgcggccg agaccgugac caagggcggg aucaugcugc cggagaaguc ccaggggaag      120

gugcuccagg ccacggucgu ggccgugggc agcgggucca agggcaaggg cggggagauc      180

cagcccguca gcgugaaggu gggcgacaag guccugcugc ccgaguacgg gggcaccaag      240

guggugcucg acgacaagga cuacuuccug uuccgggacg gggacauccu gggcaaguac      300

gucgacuga                                                              309


<210>  8622
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP10__Homo_sapiens__AAA50953

<400>  8622
auggccggcc aggccuuccg caaguuccuc ccccucuucg accgcguccu cgucgagcgc       60

uccgccgccg agaccgucac caagggcggc aucaugcucc ccgagaaguc ccagggcaag      120

guccuccagg ccaccgucgu cgccgucggc uccggcucca agggcaaggg cggcgagauc      180

cagcccgucu ccgucaaggu cggcgacaag guccuccucc ccgaguacgg cggcaccaag      240

gucguccucg acgacaagga cuacuuccuc uuccgcgacg gcgacauccu cggcaaguac      300

gucgacuga                                                              309


<210>  8623
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP10__Homo_sapiens__AAA50953

<400>  8623
auggccggcc aggcuuucag aaaguuucug ccccucuucg acagggugcu ugucgagcgg       60

agcgcagccg aaaccguuac aaaaggggga aucaugcugc cugagaaguc ccaagguaaa      120

guguugcagg cgacuguagu ggcugucggc ucugggucaa agggaaaagg cggugaaauu      180

cagccaguga guguuaaggu gggggauaag gucuuacugc cggaguacgg aggcacgaaa      240

gugguacuag acgauaagga cuauuuucuc uuccgcgaug gcgacauacu ggggaaauac      300

guugauuga                                                              309


<210>  8624
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP10__Homo_sapiens__AAA50953

<400>  8624
auggccggcc aggccuucag aaaguuccug ccccuguucg acagagugcu gguggagaga       60

agcgccgccg agaccgugac caagggcggc aucaugcugc ccgagaagag ccagggcaag      120

gugcugcagg ccaccguggu ggccgugggc agcggcagca agggcaaggg cggcgagauc      180

cagcccguga gcgugaaggu gggcgacaag gugcugcugc ccgaguacgg cggcaccaag      240

guggugcugg acgacaagga cuacuuccug uucagagacg gcgacauccu gggcaaguac      300

guggacuga                                                              309


<210>  8625
<211>  309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP10__Homo_sapiens__AAA50953

<400>  8625
auggccggcc aggcuuucag aaaguuucug ccccucuucg accgggugcu ggucgagcgc       60

agcgccgcgg aaaccguuac aaaaggggga aucaugcuuc cugagaaguc ccaaggcaaa      120

gugcugcagg cuacgguggu cgccgugggg ucuggaagca agggcaaagg gggagaaauu      180

cagccgguuu ccgugaaggu cggcgauaag gugcuccugc ccgaguacgg cgggaccaaa      240

guugugcuug acgauaagga cuauuuucug uucagagaug gagacauccu cggcaaauac      300

gucgauuga                                                              309


<210>  8626
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP75__Homo_sapiens__Q12931

<400>  8626

Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg 
1               5                   10                  15      


Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro 
            20                  25                  30          


Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn 
        35                  40                  45              


Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala 
    50                  55                  60                  


Glu Asp Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser 
65                  70                  75                  80  


Val Gln Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys 
                85                  90                  95      


Leu Leu Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe 
            100                 105                 110         


Ile Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg 
        115                 120                 125             


His Lys Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His 
    130                 135                 140                 


Leu Gln Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly 
145                 150                 155                 160 


Ile Gly Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala 
                165                 170                 175     


Arg Ser Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu 
            180                 185                 190         


Ala Ser Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala 
        195                 200                 205             


Phe Met Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro 
    210                 215                 220                 


Gly Ser Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu 
225                 230                 235                 240 


Ile Ala Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His 
                245                 250                 255     


Leu Lys Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp 
            260                 265                 270         


Val Val Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn 
        275                 280                 285             


Gly Arg Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys 
    290                 295                 300                 


Asp Val Arg Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln 
305                 310                 315                 320 


Ala His Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro 
                325                 330                 335     


Leu Asn Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met 
            340                 345                 350         


Phe Asp Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg 
        355                 360                 365             


Lys Val Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu 
    370                 375                 380                 


Arg Phe Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu 
385                 390                 395                 400 


Ser Arg Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp 
                405                 410                 415     


Val Leu Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys 
            420                 425                 430         


Asp Ala Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met 
        435                 440                 445             


Arg Glu Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile 
    450                 455                 460                 


Ala Lys Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu 
465                 470                 475                 480 


Thr Ser Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn 
                485                 490                 495     


Ile Tyr Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro 
            500                 505                 510         


Tyr Tyr Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe 
        515                 520                 525             


Glu Gln Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys 
    530                 535                 540                 


Lys Lys Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys 
545                 550                 555                 560 


Glu Glu Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu 
                565                 570                 575     


Lys Glu Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser 
            580                 585                 590         


Arg Val Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala 
        595                 600                 605             


Met Val Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met 
    610                 615                 620                 


Gln Gln Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro 
625                 630                 635                 640 


Thr Leu Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln 
                645                 650                 655     


Leu Arg Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile 
            660                 665                 670         


Tyr Glu Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala 
        675                 680                 685             


Met Val Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His 
    690                 695                 700                 






<210>  8627
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP75__Homo_sapiens__AAH18950

<400>  8627
auggcgcgcg agcugcgggc gcugcugcug uggggccgcc gccugcggcc uuugcugcgg       60

gcgccggcgc uggcggccgu gccgggagga aaaccaauuc uguguccucg gaggaccaca      120

gcccaguugg gccccaggcg aaacccagcc uggagcuugc aggcaggacg acuguucagc      180

acgcagaccg ccgaggacaa ggaggaaccc cugcacucga uuaucagcag cacagagagc      240

gugcaggguu ccacuuccaa acaugaguuc caggccgaga caaagaagcu uuuggacauu      300

guugcccggu cccuguacuc agaaaaagag guguuuauac gggagcugau cuccaaugcc      360

agcgaugccu uggaaaaacu gcgucacaaa cuggugucug acggccaagc acugccagaa      420

auggagauuc acuugcagac caaugccgag aaaggcacca ucaccaucca ggauacuggu      480

aucgggauga cacaggaaga gcuggugucc aaccugggga cgauugccag aucgggguca      540

aaggccuucc uggaugcucu gcagaaccag gcugaggcca gcagcaagau caucggccag      600

uuuggagugg guuucuacuc agcuuucaug guggcugaca gaguggaggu cuauucccgc      660

ucggcagccc cggggagccu ggguuaccag uggcuuucag augguucugg aguguuugaa      720

aucgccgaag cuucgggagu uagaaccggg acaaaaauca ucauccaccu gaaauccgac      780

ugcaaggagu uuuccagcga ggcccgggug cgagaugugg uaacgaagua cagcaacuuc      840

gucagcuucc ccuuguacuu gaauggaagg cggaugaaca ccuugcaggc caucuggaug      900

auggacccca aggauguccg ugaguggcaa caugaggagu ucuaccgcua cgucgcgcag      960

gcucacgaca agccccgcua cacccugcac uauaagacgg acgcaccgcu caacauccgc     1020

agcaucuucu acgugcccga caugaaaccg uccauguuug augugagccg ggagcugggc     1080

uccagcguug cacuguacag ccgcaaaguc cucauccaga ccaaggccac ggacauccug     1140

cccaaguggc ugcgcuucau ccgaggugug guggacagug aggacauucc ccugaaccuc     1200

agccgggagc ugcugcagga gagcgcacuc aucaggaaac uccgggacgu uuuacagcag     1260

aggcugauca aauucuucau ugaccagagu aaaaaagaug cugagaagua ugcaaaguuu     1320

uuugaagauu acggccuguu caugcgggag ggcauuguga ccgccaccga gcaggagguc     1380

aaggaggaca uagcaaagcu gcugcgcuac gaguccucgg cgcugcccuc cgggcagcua     1440

accagccucu cagaauacgc cagccgcaug cgggccggca cccgcaacau cuacuaccug     1500

ugcgccccca accgucaccu ggcagagcac ucacccuacu augaggccau gaagaagaaa     1560

gacacagagg uucucuucug cuuugagcag uuugaugagc ucacccugcu gcaccuucgu     1620

gaguuugaca agaagaagcu gaucucugug gagacggaca uagucgugga ucacuacaag     1680

gaggagaagu uugaggacag guccccagcc gccgagugcc uaucagagaa ggagacggag     1740

gagcucaugg ccuggaugag aaaugugcug gggucgcgug ucaccaacgu gaaggugacc     1800

cuccgacugg acacccaccc ugccaugguc accgugcugg agaugggggc ugcccgccac     1860

uuccugcgca ugcagcagcu ggccaagacc caggaggagc gcgcacagcu ccugcagccc     1920

acgcuggaga ucaaccccag gcacgcgcuc aucaagaagc ugaaucagcu gcgcgcaagc     1980

gagccuggcc uggcucagcu gcugguggau cagauauacg agaacgccau gauugcugcu     2040

ggacuuguug acgacccuag ggccauggug ggccgcuuga augagcugcu ugucaaggcc     2100

cuggagcgac acuga                                                      2115


<210>  8628
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP75__Homo_sapiens__AAH18950

<400>  8628
auggcccgcg agcugcgggc ccuccugcug uggggccgcc ggcuccgccc ccugcugcgg       60

gcgccggccc ucgccgccgu gcccgggggc aagcccaucc ugugcccccg ccggaccacc      120

gcccagcugg ggccgcgccg gaaccccgcg uggagccucc aggccggccg ccuguucucc      180

acgcagaccg ccgaggacaa ggaggagccc cugcacagca ucaucuccag caccgagucc      240

guccagggga gcaccuccaa gcacgaguuc caggccgaga cgaagaagcu ccuggacauc      300

guggcgcgga gccuguacuc cgagaaggag guguucaucc gcgagcucau cagcaacgcc      360

uccgacgccc uggagaagcu gcggcacaag cucgucagcg acggccaggc ccugcccgag      420

auggagaucc accuccagac caacgccgag aagggcacca ucaccaucca ggacacgggg      480

aucggcauga cccaggagga gcuggugucc aaccugggga ccaucgcgcg cagcggcucc      540

aaggccuucc uggacgcccu ccagaaccag gccgaggcca gcuccaagau caucgggcag      600

uucggcgugg gcuucuacag cgcguucaug gucgccgacc ggguggaggu guacucccgc      660

agcgccgccc cggggagccu gggcuaccag uggcuguccg acgggagcgg cgucuucgag      720

aucgccgagg cguccggcgu gcggaccggg acgaagauca ucauccaccu caagagcgac      780

ugcaaggagu ucuccagcga ggcccgcgug cgggacgucg ugaccaagua cuccaacuuc      840

gugagcuucc cccuguaccu gaacggccgc cggaugaaca cccuccaggc caucuggaug      900

auggacccca aggacguccg cgaguggcag cacgaggagu ucuaccgcua cguggcccag      960

gcccacgaca agccccggua cacccugcac uacaagacgg acgcgccgcu gaacauccgc     1020

uccaucuucu acgugcccga caugaagccc agcauguucg acgucucccg ggagcucggg     1080

agcuccgugg cccuguacag ccgcaaggug cugauccaga ccaaggccac cgacauccuc     1140

cccaaguggc ugcgguucau ccgcggcguc guggacuccg aggacauccc gcugaaccuc     1200

agccgggagc ugcugcagga guccgcccuc auccgcaagc ugcgggacgu gcugcagcag     1260

cgccucauca aguucuucau cgaccagagc aagaaggacg cggagaagua cgccaaguuc     1320

uucgaggacu acgggcuguu caugcgggag ggcaucguca ccgccacgga gcaggaggug     1380

aaggaggaca ucgccaagcu gcuccgcuac gaguccagcg cccugcccag cggccagcug     1440

accucccuga gcgaguacgc gucccggaug cgcgccggga cccggaacau cuacuaccuc     1500

ugcgccccca accgccaccu ggccgagcac agccccuacu acgaggccau gaagaagaag     1560

gacaccgagg uccuguucug cuucgagcag uucgacgagc ucacgcugcu gcaccuccgg     1620

gaguucgaca agaagaagcu gaucuccgug gagaccgaca ucguggucga ccacuacaag     1680

gaggagaagu ucgaggaccg cagcccggcg gccgagugcc uguccgagaa ggagaccgag     1740

gagcucaugg ccuggaugcg gaacgugcug ggcagccgcg ugaccaacgu caaggugacg     1800

cugcgccucg acacccaccc cgccauggug accguccugg agaugggggc cgcgcggcac     1860

uuccugcgca ugcagcagcu cgccaagacc caggaggagc gggcccagcu gcugcagccc     1920

acgcucgaga ucaacccccg ccacgcccug aucaagaagc ugaaccagcu ccgggcgucc     1980

gagccgggcc uggcccagcu gcucguggac cagaucuacg agaacgccau gaucgccgcc     2040

gggcuggugg acgacccccg cgcgaugguc ggccggcuga acgagcuccu ggugaaggcc     2100

cuggagcgcc acuga                                                      2115


<210>  8629
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP75__Homo_sapiens__AAH18950

<400>  8629
auggcccgcg agcuccgcgc ccuccuccuc uggggccgcc gccuccgccc ccuccuccgc       60

gcccccgccc ucgccgccgu ccccggcggc aagcccaucc ucugcccccg ccgcaccacc      120

gcccagcucg gcccccgccg caaccccgcc uggucccucc aggccggccg ccucuucucc      180

acccagaccg ccgaggacaa ggaggagccc cuccacucca ucaucuccuc caccgagucc      240

guccagggcu ccaccuccaa gcacgaguuc caggccgaga ccaagaagcu ccucgacauc      300

gucgcccgcu cccucuacuc cgagaaggag gucuucaucc gcgagcucau cuccaacgcc      360

uccgacgccc ucgagaagcu ccgccacaag cucgucuccg acggccaggc ccuccccgag      420

auggagaucc accuccagac caacgccgag aagggcacca ucaccaucca ggacaccggc      480

aucggcauga cccaggagga gcucgucucc aaccucggca ccaucgcccg cuccggcucc      540

aaggccuucc ucgacgcccu ccagaaccag gccgaggccu ccuccaagau caucggccag      600

uucggcgucg gcuucuacuc cgccuucaug gucgccgacc gcgucgaggu cuacucccgc      660

uccgccgccc ccggcucccu cggcuaccag uggcucuccg acggcuccgg cgucuucgag      720

aucgccgagg ccuccggcgu ccgcaccggc accaagauca ucauccaccu caaguccgac      780

ugcaaggagu ucuccuccga ggcccgcguc cgcgacgucg ucaccaagua cuccaacuuc      840

gucuccuucc cccucuaccu caacggccgc cgcaugaaca cccuccaggc caucuggaug      900

auggacccca aggacguccg cgaguggcag cacgaggagu ucuaccgcua cgucgcccag      960

gcccacgaca agccccgcua cacccuccac uacaagaccg acgccccccu caacauccgc     1020

uccaucuucu acguccccga caugaagccc uccauguucg acgucucccg cgagcucggc     1080

uccuccgucg cccucuacuc ccgcaagguc cucauccaga ccaaggccac cgacauccuc     1140

cccaaguggc uccgcuucau ccgcggcguc gucgacuccg aggacauccc ccucaaccuc     1200

ucccgcgagc uccuccagga guccgcccuc auccgcaagc uccgcgacgu ccuccagcag     1260

cgccucauca aguucuucau cgaccagucc aagaaggacg ccgagaagua cgccaaguuc     1320

uucgaggacu acggccucuu caugcgcgag ggcaucguca ccgccaccga gcaggagguc     1380

aaggaggaca ucgccaagcu ccuccgcuac gaguccuccg cccuccccuc cggccagcuc     1440

accucccucu ccgaguacgc cucccgcaug cgcgccggca cccgcaacau cuacuaccuc     1500

ugcgccccca accgccaccu cgccgagcac ucccccuacu acgaggccau gaagaagaag     1560

gacaccgagg uccucuucug cuucgagcag uucgacgagc ucacccuccu ccaccuccgc     1620

gaguucgaca agaagaagcu caucuccguc gagaccgaca ucgucgucga ccacuacaag     1680

gaggagaagu ucgaggaccg cucccccgcc gccgagugcc ucuccgagaa ggagaccgag     1740

gagcucaugg ccuggaugcg caacguccuc ggcucccgcg ucaccaacgu caaggucacc     1800

cuccgccucg acacccaccc cgccaugguc accguccucg agaugggcgc cgcccgccac     1860

uuccuccgca ugcagcagcu cgccaagacc caggaggagc gcgcccagcu ccuccagccc     1920

acccucgaga ucaacccccg ccacgcccuc aucaagaagc ucaaccagcu ccgcgccucc     1980

gagcccggcc ucgcccagcu ccucgucgac cagaucuacg agaacgccau gaucgccgcc     2040

ggccucgucg acgacccccg cgccaugguc ggccgccuca acgagcuccu cgucaaggcc     2100

cucgagcgcc acuga                                                      2115


<210>  8630
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP75__Homo_sapiens__AAH18950

<400>  8630
auggccagag agcugagggc ucuccuucug uggggccggc gcuugcgacc cuuacugcgu       60

gcuccugccc uagcggcugu gccaggggga aagccgaucc ucugccccag aaggaccaca      120

gcccagcugg guccucggcg caacccagca uggagccuuc aagccggcag acuguucucc      180

acucagacgg cugaagacaa agaggaaccc uugcacucua uuauaucaag uaccgagagc      240

guccaggggu ccacaucuaa gcaugaauuu caggcagaga cuaaaaagcu ccuggauauc      300

guugccaggu cgcuguacuc agagaaagaa guguucauuc gggagcucau cagcaaugcu      360

agugacgccu uagaaaagcu gcgccacaag cuaguauccg auggacaagc guugccugag      420

auggagauuc aucugcagac caacgcagaa aaaggcacaa ucaccauaca ggacacuggu      480

aucgggauga cacaggagga acuugugucu aaucucggaa ccauugcccg aagcggcucc      540

aaggcuuuuc uggaugcccu ucaaaaccag gcagaggcuu caaguaaaau cauuggccag      600

uucggggucg gauuuuauag cgccuucaug guggcggaca gaguugaagu guacucuagg      660

uccgccgcac cagguucacu gggcuaucag ugguugagcg augggagugg agucuuugag      720

aucgcugagg ccucuggcgu gcggacgggu acuaagauaa uuauccaccu caaauccgac      780

uguaaggaau uuagcucgga ggcucgugua cgcgauguug ugaccaagua cucuaauuuu      840

gucuccuucc cccuguauuu aaacgggaga aggaugaaua cacugcaagc cauuuggaug      900

auggacccua aagaugugcg ggaauggcag caugaggaau uuuaccgaua uguggcacag      960

gcccacgaca agccacgcua cacucuccac uacaaaaccg augcuccgcu uaacaucaga     1020

ucaaucuucu auguccccga caugaagccu aguauguuug acguuagcag ggagcuggga     1080

uccucugugg cguuguacag ccggaaagua cuaauucaaa caaaggcaac cgauauacug     1140

ccaaaauggc uccgcuucau cagaggcgug gucgacucag aggauauucc ccugaaucuu     1200

aguagggaac uguugcagga guccgcccuc auccguaagc ugcgggacgu guuacagcag     1260

cgacugauaa aguucuuuau ugaucaaagc aaaaaggacg cugaaaaaua ugccaaguuc     1320

uuugaggauu acggccuauu caugagagaa gggaucguua cggcaacuga gcaggaggug     1380

aaagaagaca ucgccaagcu ccugagguau gagucuucag cacuuccuag uggacaguug     1440

acaagccugu ccgaauacgc cucucgcaug cgggcaggua ccagaaacau uuauuaccuc     1500

ugcgcgccaa auaggcaucu ggcugagcac ucgcccuacu augaggccau gaagaaaaag     1560

gauacugaag uccuuuucug uuucgagcag uuugacgaac ugacauugcu ccaucugcgc     1620

gaguucgaua aaaagaaauu aaucagcgug gaaaccgaca uuguaguuga ccacuacaag     1680

gaggagaagu uugaagaucg auccccggca gccgagugcc ugucagaaaa agagacggaa     1740

gaacuaaugg cuuggaugcg gaacgugcuc ggcagucgug ucaccaaugu gaaggucaca     1800

cugagacuug acacucaccc ugccauggug accguuuugg agaugggggc agcuaggcau     1860

uuccugcgca ugcaacagcu cgccaaaaca caggaggagc gggcgcagcu guuacaaccc     1920

acucuggaaa uaaacccaag acacgcccuu aucaagaaau ugaaucagcu cagggcuucu     1980

gagccuggac uggcacagcu acugguggau cagauuuaug aaaacgccau gaucgcugcc     2040

ggccucguag acgauccccg agcaaugguc ggucgccuga acgagcuuuu ggugaaggcg     2100

cuggagcggc auuga                                                      2115


<210>  8631
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP75__Homo_sapiens__AAH18950

<400>  8631
auggccagag agcugagagc ccugcugcug uggggcagaa gacugagacc ccugcugaga       60

gcccccgccc uggccgccgu gcccggcggc aagcccaucc ugugccccag aagaaccacc      120

gcccagcugg gccccagaag aaaccccgcc uggagccugc aggccggcag acuguucagc      180

acccagaccg ccgaggacaa ggaggagccc cugcacagca ucaucagcag caccgagagc      240

gugcagggca gcaccagcaa gcacgaguuc caggccgaga ccaagaagcu gcuggacauc      300

guggccagaa gccuguacag cgagaaggag guguucauca gagagcugau cagcaacgcc      360

agcgacgccc uggagaagcu gagacacaag cuggugagcg acggccaggc ccugcccgag      420

auggagaucc accugcagac caacgccgag aagggcacca ucaccaucca ggacaccggc      480

aucggcauga cccaggagga gcuggugagc aaccugggca ccaucgccag aagcggcagc      540

aaggccuucc uggacgcccu gcagaaccag gccgaggcca gcagcaagau caucggccag      600

uucggcgugg gcuucuacag cgccuucaug guggccgaca gaguggaggu guacagcaga      660

agcgccgccc ccggcagccu gggcuaccag uggcugagcg acggcagcgg cguguucgag      720

aucgccgagg ccagcggcgu gagaaccggc accaagauca ucauccaccu gaagagcgac      780

ugcaaggagu ucagcagcga ggccagagug agagacgugg ugaccaagua cagcaacuuc      840

gugagcuucc cccuguaccu gaacggcaga agaaugaaca cccugcaggc caucuggaug      900

auggacccca aggacgugag agaguggcag cacgaggagu ucuacagaua cguggcccag      960

gcccacgaca agcccagaua cacccugcac uacaagaccg acgccccccu gaacaucaga     1020

agcaucuucu acgugcccga caugaagccc agcauguucg acgugagcag agagcugggc     1080

agcagcgugg cccuguacag cagaaaggug cugauccaga ccaaggccac cgacauccug     1140

cccaaguggc ugagauucau cagaggcgug guggacagcg aggacauccc ccugaaccug     1200

agcagagagc ugcugcagga gagcgcccug aucagaaagc ugagagacgu gcugcagcag     1260

agacugauca aguucuucau cgaccagagc aagaaggacg ccgagaagua cgccaaguuc     1320

uucgaggacu acggccuguu caugagagag ggcaucguga ccgccaccga gcaggaggug     1380

aaggaggaca ucgccaagcu gcugagauac gagagcagcg cccugcccag cggccagcug     1440

accagccuga gcgaguacgc cagcagaaug agagccggca ccagaaacau cuacuaccug     1500

ugcgccccca acagacaccu ggccgagcac agccccuacu acgaggccau gaagaagaag     1560

gacaccgagg ugcuguucug cuucgagcag uucgacgagc ugacccugcu gcaccugaga     1620

gaguucgaca agaagaagcu gaucagcgug gagaccgaca ucguggugga ccacuacaag     1680

gaggagaagu ucgaggacag aagccccgcc gccgagugcc ugagcgagaa ggagaccgag     1740

gagcugaugg ccuggaugag aaacgugcug ggcagcagag ugaccaacgu gaaggugacc     1800

cugagacugg acacccaccc cgccauggug accgugcugg agaugggcgc cgccagacac     1860

uuccugagaa ugcagcagcu ggccaagacc caggaggaga gagcccagcu gcugcagccc     1920

acccuggaga ucaaccccag acacgcccug aucaagaagc ugaaccagcu gagagccagc     1980

gagcccggcc uggcccagcu gcugguggac cagaucuacg agaacgccau gaucgccgcc     2040

ggccuggugg acgaccccag agccauggug ggcagacuga acgagcugcu ggugaaggcc     2100

cuggagagac acuga                                                      2115


<210>  8632
<211>  2115
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP75__Homo_sapiens__AAH18950

<400>  8632
auggccagag agcugcgggc ucuccugcuu uggggccgca gacugcggcc ccuccugcgc       60

gccccugcgc uugcugccgu gcccggggga aagccgaucc ugugcccuag acggaccaca      120

gcccagcucg gcccccgcag aaacccugcu uggagccugc aagccgggcg gcuguucucc      180

acgcagaccg cugaagacaa agaggaaccc cuccacucua uuaucagcuc cacagagucu      240

guccagggaa gcaccuccaa gcaugaauuu caggccgaga caaagaagcu gcuugauauu      300

guugcgcgcu cucuguacag cgagaaagaa guguucauca gagagcucau uuccaaugcc      360

agcgacgcuc uggaaaaacu ucggcacaag cuggugucug auggccaagc ccucccugag      420

auggagaucc aucugcagac caacgcugaa aaagggacaa ucaccauuca ggacacggga      480

aucggcauga cccaggagga acuggucucc aaucucggca caauugcccg cagcgggucu      540

aaggcguuuc uggaugcccu ucaaaaccag gcugaggccu ccagcaaaau cauuggacag      600

uucggcgugg gguuuuauuc ugcuuucaug guugccgaca gaguggaagu cuacucccgg      660

agcgccgcuc cgggaucccu gggcuaucag uggcucucug augggagcgg aguguuugag      720

aucgcggagg ccuccggcgu ucgcaccggc acaaagauua ucauccaccu gaaaagcgac      780

uguaaggagu ucucuuccga ggcuagagug cgggaugucg ugaccaagua cagcaauuuu      840

gugucuuucc cccuuuaucu gaacgggaga cgcaugaaua cgcuccaagc cauuuggaug      900

auggacccua aagauguccg ggaauggcag caugaggaau uuuacagaua uguugcccag      960

gcucacgaca agccccgcua cacacugcac uacaaaaccg augccccucu gaacauccgg     1020

agcauuuucu augugcccga caugaagccg uccauguuug acgugucuag agagcucgga     1080

agcuccgucg cgcuguacag ccgcaaagug cuuauccaaa caaaggcuac cgauauucug     1140

ccuaaauggc uccgguucau cagaggcguu guggacucug aggauauccc ccugaaucuu     1200

ucccgcgaac ugcuccagga gagcgcccug auucggaagc ugagagacgu ccuccagcag     1260

cgccugauca aguucuuuau ugaucaaucu aaaaaggacg ccgaaaaaua ugcuaaguuc     1320

uuugaggauu acgggcuuuu caugcgggaa ggaaucguga ccgccacaga gcaggagguu     1380

aaagaagaca uugcuaagcu gcucagauau gaguccagcg cccugccuuc cggccagcug     1440

acgucucuua gcgaauacgc gucccggaug cgcgccggga ccagaaacau cuauuaccuc     1500

ugcgcuccca aucggcaucu ggccgagcac ucucccuacu augaggcuau gaagaaaaag     1560

gauacagaag ugcuguuuug uuucgagcag uuugacgaac ucacccugcu ucaucugaga     1620

gaguucgaua aaaagaaacu caucagcguc gaaacagaca uuguggucga ccacuacaag     1680

gaggagaagu uugaagaucg cuccccugcc gcggagugcc ugagcgaaaa agagaccgaa     1740

gaacugaugg ccuggaugcg gaacgugcuu ggaucuagag uuacgaaugu gaaggucaca     1800

cuccgccugg acacccaccc ggcuauggug accguucugg agaugggcgc cgcuagacau     1860

uuccuccgga ugcaacagcu ggccaaaaca caggaggaac gcgcccagcu ucugcaaccc     1920

acccucgaaa ucaacccuag acacgcucug auuaagaaac ugaaucagcu ucgggcgucc     1980

gagcccggcc ucgcccagcu gcugguggau cagaucuaug aaaacgcuau gauugccgcc     2040

gggcucgucg acgauccucg cgcuauggug ggaagacuga acgagcuucu ggugaaggcc     2100

cucgagcggc auuga                                                      2115


<210>  8633
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HSP90B1__Homo_sapiens__Q5CAQ5

<400>  8633

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys Asp 
785                 790                 795                 800 


Glu Leu 
        


<210>  8634
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  HSP90B1__Homo_sapiens__CAI64497

<400>  8634
augagggccc ugugggugcu gggccucugc ugcguccugc ugaccuucgg gucggucaga       60

gcugacgaug aaguugaugu ggaugguaca guagaagagg aucuggguaa aaguagagaa      120

ggaucaagga cggaugauga aguaguacag agagaggaag aagcuauuca guuggaugga      180

uuaaaugcau cacaaauaag agaacuuaga gagaagucgg aaaaguuugc cuuccaagcc      240

gaaguuaaca gaaugaugaa acuuaucauc aauucauugu auaaaaauaa agagauuuuc      300

cugagagaac ugauuucaaa ugcuucugau gcuuuagaua agauaaggcu aauaucacug      360

acugaugaaa augcucuuuc uggaaaugag gaacuaacag ucaaaauuaa gugugauaag      420

gagaagaacc ugcugcaugu cacagacacc gguguaggaa ugaccagaga agaguugguu      480

aaaaaccuug guaccauagc caaaucuggg acaagcgagu uuuuaaacaa aaugacugaa      540

gcacaggaag auggccaguc aacuucugaa uugauuggcc aguuuggugu cgguuucuau      600

uccgccuucc uuguagcaga uaagguuauu gucacuucaa aacacaacaa cgauacucag      660

cacaucuggg agucugacuc caaugaauuu ucuguaauug cugacccaag aggaaacacu      720

cuaggacggg gaacgacaau uacccuuguc uuaaaagaag aagcaucuga uuaccuugaa      780

uuggauacaa uuaaaaaucu cgucaaaaaa uauucacagu ucauaaacuu uccuauuuau      840

guauggagca gcaagacuga aacuguugag gagcccaugg aggaagaaga agcagccaaa      900

gaagagaaag aagaaucuga ugaugaagcu gcaguagagg aagaagaaga agaaaagaaa      960

ccaaagacua aaaaaguuga aaaaacuguc ugggacuggg aacuuaugaa ugauaucaaa     1020

ccaauauggc agagaccauc aaaagaagua gaagaagaug aauacaaagc uuucuacaaa     1080

ucauuuucaa aggaaaguga ugaccccaug gcuuauauuc acuuuacugc ugaaggggaa     1140

guuaccuuca aaucaauuuu auuuguaccc acaucugcuc cacguggucu guuugacgaa     1200

uauggaucua aaaagagcga uuacauuaag cucuaugugc gccguguauu caucacagac     1260

gacuuccaug auaugaugcc uaaauaccuc aauuuuguca aggguguggu ggacucagau     1320

gaucuccccu ugaauguuuc ccgcgagacu cuucagcaac auaaacugcu uaaggugauu     1380

aggaagaagc uuguucguaa aacgcuggac augaucaaga agauugcuga ugauaaauac     1440

aaugauacuu uuuggaaaga auuugguacc aacaucaagc uuggugugau ugaagaccac     1500

ucgaaucgaa cacgucuugc uaaacuucuu agguuccagu cuucucauca uccaacugac     1560

auuacuagcc uagaccagua uguggaaaga augaaggaaa aacaagacaa aaucuacuuc     1620

auggcugggu ccagcagaaa agaggcugaa ucuucuccau uuguugagcg acuucugaaa     1680

aagggcuaug aaguuauuua ccucacagaa ccuguggaug aauacuguau ucaggcccuu     1740

cccgaauuug augggaagag guuccagaau guugccaagg aaggagugaa guucgaugaa     1800

agugagaaaa cuaaggagag ucgugaagca guugagaaag aauuugagcc ucugcugaau     1860

uggaugaaag auaaagcccu uaaggacaag auugaaaagg cugugguguc ucagcgccug     1920

acagaaucuc cgugugcuuu gguggccagc caguacggau ggucuggcaa cauggagaga     1980

aucaugaaag cacaagcgua ccaaacgggc aaggacaucu cuacaaauua cuaugcgagu     2040

cagaagaaaa cauuugaaau uaaucccaga cacccgcuga ucagagacau gcuucgacga     2100

auuaaggaag augaagauga uaaaacaguu uuggaucuug cugugguuuu guuugaaaca     2160

gcaacgcuuc ggucagggua ucuuuuacca gacacuaaag cauauggaga uagaauagaa     2220

agaaugcuuc gccucaguuu gaacauugac ccugaugcaa agguggaaga agagcccgaa     2280

gaagaaccug aagagacagc agaagacaca acagaagaca cagagcaaga cgaagaugaa     2340

gaaauggaug ugggaacaga ugaagaagaa acagcaaagg aaucuacagc ugaaaaagau     2400

gaauuguaa                                                             2409


<210>  8635
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       HSP90B1__Homo_sapiens__CAI64497

<400>  8635
augcgcgccc ugugggugcu cggccugugc ugcguccugc ucaccuucgg gagcgugcgg       60

gccgacgacg agguggacgu cgacggcacc guggaggagg accuggggaa gucccgcgag      120

ggcagccgga cggacgacga ggugguccag cgcgaggagg aggcgaucca gcuggacggg      180

cucaacgccu cccagauccg ggagcugcgc gagaaguccg agaaguucgc cuuccaggcc      240

gaggugaacc ggaugaugaa gcugaucauc aacagccucu acaagaacaa ggagaucuuc      300

cugcgcgagc ugaucagcaa cgccuccgac gcgcucgaca agauccggcu gaucagccug      360

accgacgaga acgcccucuc cggcaacgag gagcugaccg ugaagaucaa gugcgacaag      420

gagaagaacc ugcuccacgu caccgacacg ggcgugggga ugacccgcga ggagcuggug      480

aagaaccugg gcaccaucgc caagagcggg accuccgagu uccucaacaa gaugacggag      540

gcccaggagg acggccagag caccuccgag cugaucgggc aguucggcgu cggcuucuac      600

agcgcguucc ugguggccga caaggugauc gucaccucca agcacaacaa cgacacccag      660

cacaucuggg agagcgacuc caacgaguuc agcgugaucg ccgacccccg ggggaacacg      720

cucggccgcg ggaccaccau cacccuggug cugaaggagg aggccuccga cuaccucgag      780

cuggacacga ucaagaaccu ggucaagaag uacagccagu ucaucaacuu cccgaucuac      840

guguggagcu ccaagaccga gaccguggag gagcccaugg aggaggagga ggccgcgaag      900

gaggagaagg aggagagcga cgacgaggcc gccgucgagg aggaggagga ggagaagaag      960

cccaagacca agaaggugga gaagacggug ugggacuggg agcucaugaa cgacaucaag     1020

cccaucuggc agcggccguc caaggagguc gaggaggacg aguacaaggc cuucuacaag     1080

agcuucucca aggagagcga cgaccccaug gccuacaucc acuucaccgc ggagggcgag     1140

gugaccuuca aguccauccu guucgucccc accagcgcgc cccgcggccu guucgacgag     1200

uacgggucca agaaguccga cuacaucaag cucuacgugc ggcgcguguu caucacggac     1260

gacuuccacg acaugaugcc gaaguaccug aacuucguca agggcguggu ggacagcgac     1320

gaccugcccc ucaacgucag ccgggagacc cugcagcagc acaagcugcu caaggugauc     1380

cgcaagaagc uggugcggaa gacccuggac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucgggacg aacaucaagc ucggcgucau cgaggaccac     1500

uccaaccgca cccggcuggc caagcugcuc cgcuuccaga gcucccacca ccccaccgac     1560

aucaccagcc uggaccagua cguggagcgc augaaggaga agcaggacaa gaucuacuuc     1620

auggccgggu ccagccggaa ggaggccgag uccagccccu ucguggagcg ccugcucaag     1680

aagggcuacg aggucaucua ccugacggag ccgguggacg aguacugcau ccaggcccug     1740

cccgaguucg acggcaagcg guuccagaac guggccaagg agggggucaa guucgacgag     1800

agcgagaaga ccaaggaguc ccgcgaggcc guggagaagg aguucgagcc ccugcucaac     1860

uggaugaagg acaaggcccu gaaggacaag aucgagaagg cgguggucag ccagcggcug     1920

accgaguccc ccugcgcccu cguggccagc caguacggcu gguccgggaa cauggagcgc     1980

aucaugaagg cccaggcgua ccagaccggc aaggacauca gcacgaacua cuacgccucc     2040

cagaagaaga ccuucgagau caacccgcgg cacccccuga uccgcgacau gcugcggcgc     2100

aucaaggagg acgaggacga caagaccgug cucgaccugg ccgucgugcu guucgagacc     2160

gccacccucc ggagcgggua ccugcugccc gacacgaagg ccuacggcga ccgcaucgag     2220

cggaugcucc gccugucccu gaacaucgac cccgacgcga agguggagga ggagccggag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca cggagcagga cgaggacgag     2340

gagauggacg ucggcaccga cgaggaggag accgccaagg agagcaccgc cgagaaggac     2400

gagcucuga                                                             2409


<210>  8636
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       HSP90B1__Homo_sapiens__CAI64497

<400>  8636
augcgcgccc ucuggguccu cggccucugc ugcguccucc ucaccuucgg cuccguccgc       60

gccgacgacg aggucgacgu cgacggcacc gucgaggagg accucggcaa gucccgcgag      120

ggcucccgca ccgacgacga ggucguccag cgcgaggagg aggccaucca gcucgacggc      180

cucaacgccu cccagauccg cgagcuccgc gagaaguccg agaaguucgc cuuccaggcc      240

gaggucaacc gcaugaugaa gcucaucauc aacucccucu acaagaacaa ggagaucuuc      300

cuccgcgagc ucaucuccaa cgccuccgac gcccucgaca agauccgccu caucucccuc      360

accgacgaga acgcccucuc cggcaacgag gagcucaccg ucaagaucaa gugcgacaag      420

gagaagaacc uccuccacgu caccgacacc ggcgucggca ugacccgcga ggagcucguc      480

aagaaccucg gcaccaucgc caaguccggc accuccgagu uccucaacaa gaugaccgag      540

gcccaggagg acggccaguc caccuccgag cucaucggcc aguucggcgu cggcuucuac      600

uccgccuucc ucgucgccga caaggucauc gucaccucca agcacaacaa cgacacccag      660

cacaucuggg aguccgacuc caacgaguuc uccgucaucg ccgacccccg cggcaacacc      720

cucggccgcg gcaccaccau cacccucguc cucaaggagg aggccuccga cuaccucgag      780

cucgacacca ucaagaaccu cgucaagaag uacucccagu ucaucaacuu ccccaucuac      840

gucugguccu ccaagaccga gaccgucgag gagcccaugg aggaggagga ggccgccaag      900

gaggagaagg aggaguccga cgacgaggcc gccgucgagg aggaggagga ggagaagaag      960

cccaagacca agaaggucga gaagaccguc ugggacuggg agcucaugaa cgacaucaag     1020

cccaucuggc agcgccccuc caaggagguc gaggaggacg aguacaaggc cuucuacaag     1080

uccuucucca aggaguccga cgaccccaug gccuacaucc acuucaccgc cgagggcgag     1140

gucaccuuca aguccauccu cuucgucccc accuccgccc cccgcggccu cuucgacgag     1200

uacggcucca agaaguccga cuacaucaag cucuacgucc gccgcgucuu caucaccgac     1260

gacuuccacg acaugaugcc caaguaccuc aacuucguca agggcgucgu cgacuccgac     1320

gaccuccccc ucaacgucuc ccgcgagacc cuccagcagc acaagcuccu caaggucauc     1380

cgcaagaagc ucguccgcaa gacccucgac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucggcacc aacaucaagc ucggcgucau cgaggaccac     1500

uccaaccgca cccgccucgc caagcuccuc cgcuuccagu ccucccacca ccccaccgac     1560

aucaccuccc ucgaccagua cgucgagcgc augaaggaga agcaggacaa gaucuacuuc     1620

auggccggcu ccucccgcaa ggaggccgag uccucccccu ucgucgagcg ccuccucaag     1680

aagggcuacg aggucaucua ccucaccgag cccgucgacg aguacugcau ccaggcccuc     1740

cccgaguucg acggcaagcg cuuccagaac gucgccaagg agggcgucaa guucgacgag     1800

uccgagaaga ccaaggaguc ccgcgaggcc gucgagaagg aguucgagcc ccuccucaac     1860

uggaugaagg acaaggcccu caaggacaag aucgagaagg ccgucgucuc ccagcgccuc     1920

accgaguccc ccugcgcccu cgucgccucc caguacggcu gguccggcaa cauggagcgc     1980

aucaugaagg cccaggccua ccagaccggc aaggacaucu ccaccaacua cuacgccucc     2040

cagaagaaga ccuucgagau caacccccgc cacccccuca uccgcgacau gcuccgccgc     2100

aucaaggagg acgaggacga caagaccguc cucgaccucg ccgucguccu cuucgagacc     2160

gccacccucc gcuccggcua ccuccucccc gacaccaagg ccuacggcga ccgcaucgag     2220

cgcaugcucc gccucucccu caacaucgac cccgacgcca aggucgagga ggagcccgag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca ccgagcagga cgaggacgag     2340

gagauggacg ucggcaccga cgaggaggag accgccaagg aguccaccgc cgagaaggac     2400

gagcucuga                                                             2409


<210>  8637
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       HSP90B1__Homo_sapiens__CAI64497

<400>  8637
augagagccc ugugggugcu cggccuuugc uguguccugu ugaccuucgg gagcguuagg       60

gcugacgaug agguggacgu agauggaaca guggaagagg acuuagguaa gucccgggaa      120

ggcucucgca cugaugacga ggucgugcag cgagaagagg aggcaaucca acuggauggg      180

cuaaacgccu cacagauucg ugaacucaga gagaaaagug aaaaguuugc guuccaggcu      240

gagguuaaua ggaugaugaa acugauaauc aacagccuuu acaagaauaa agagauuuuu      300

cugcgggaau ugaucuccaa cgccucugac gcacucgaua agauucgccu gaucucgcug      360

acggacgaga augcccucuc aggaaacgaa gaguuaaccg ugaagauaaa augcgauaag      420

gagaaaaauc ugcuucacgu cacagacacu ggcgugggua ugaccagaga ggaguuggua      480

aagaaccugg ggacaaucgc uaaaagcgga accagugagu uccuaaauaa gaugacugaa      540

gcacaggaag auggccaauc cacaucugag cucauuggcc aguuuggggu uggauucuau      600

agcgccuuuc ugguggcuga caaggucauc gugaccucca aacauaacaa ugacacgcag      660

cacauuuggg aaucagauag uaacgaguuc agcgugaucg ccgaccccag ggguaauacu      720

cuuggccggg ggaccacaau aacucugguc uugaaggagg aagcgucuga uuaccucgag      780

cuggacacca uuaaaaacuu aguuaagaaa uauucccagu uuaucaauuu cccuauuuac      840

guguggucaa gcaagacaga aaccguagag gaaccaaugg aggaggaaga ggcagccaaa      900

gaagagaagg aggaaaguga ugacgaggcu gccguggaag aggaagagga ggaaaagaaa      960

ccgaagacga aaaaggucga gaaaacugug ugggauuggg aacugaugaa cgacaucaag     1020

cccaucuggc aacgcccuuc uaaggagguu gaagaggaug aguauaaagc auuuuacaag     1080

uccuucagca aagaaucgga cgauccaaug gcuuauauuc auuuuacagc cgagggagaa     1140

gugaccuuca agucuauacu cuucgucccc acuuccgcgc cucgaggccu uuuugacgag     1200

uacgguagua aaaagucaga cuacaucaag cuguauguga gaaggguauu cauuacagau     1260

gacuuucacg auaugaugcc aaaauacuug aacuucguua aggggguggu cgacagcgau     1320

gaccuacccc ugaauguguc ccgggaaacc cuccagcagc auaaacugcu uaaggucauc     1380

cguaaaaagc uggugcgcaa gacguuggau augauuaaaa agauagccga cgauaaauau     1440

aacgacaccu uuuggaagga guucggaaca aauaucaaac ucggcguuau cgaggaucac     1500

ucuaacagaa cuaggcuggc aaaguuacug cgguuucaga gcucacacca uccuaccgac     1560

auuacaaguc uagaucaaua cguggaacga augaaagaga agcaggacaa gaucuauuuc     1620

auggcuggcu ccagccgcaa agaagccgag ucuucaccau uuguagagag acuccugaag     1680

aaaggguacg aagucauuua ucuuacugag ccgguggacg aauacuguau acaggcuuug     1740

cccgaguucg auggaaagag guuucaaaau guugccaaag aaggugugaa guucgacgag     1800

agugagaaga ccaaagaaag ccgggaggca gucgaaaagg aguuugaacc ucugcucaac     1860

uggaugaaag auaaggcccu gaaagacaag aucgagaagg cugugguauc ccagcgccuu     1920

acagagucuc caugcgcgcu gguggcaucg caguacggcu ggagcgggaa uauggaaaga     1980

auuaugaaag cccaggcuua ucaaaccgga aaggauaucu ccacuaacua cuaugccuca     2040

cagaaaaaga cguucgagau caaucccagg cacccuuuga uucgugacau gcuccggcga     2100

auaaaagaag augaggacga uaagacaguu cuggacuuag cagucgugcu guucgaaacc     2160

gccacucuaa gaaguggcua ccuccugcca gauaccaagg cuuaugguga caggaucgag     2220

cgcaugcuuc gguugucucu gaacauugau cccgacgcca aaguggagga agaaccggaa     2280

gaggagccug aagagacagc agaagacacc acugaggaua cagaacagga cgaggaugag     2340

gaaauggacg ucgggacgga ugaggaagag accgcgaagg aaagcacugc ugagaaagac     2400

gagcucuga                                                             2409


<210>  8638
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       HSP90B1__Homo_sapiens__CAI64497

<400>  8638
augagagccc ugugggugcu gggccugugc ugcgugcugc ugaccuucgg cagcgugaga       60

gccgacgacg agguggacgu ggacggcacc guggaggagg accugggcaa gagcagagag      120

ggcagcagaa ccgacgacga gguggugcag agagaggagg aggccaucca gcuggacggc      180

cugaacgcca gccagaucag agagcugaga gagaagagcg agaaguucgc cuuccaggcc      240

gaggugaaca gaaugaugaa gcugaucauc aacagccugu acaagaacaa ggagaucuuc      300

cugagagagc ugaucagcaa cgccagcgac gcccuggaca agaucagacu gaucagccug      360

accgacgaga acgcccugag cggcaacgag gagcugaccg ugaagaucaa gugcgacaag      420

gagaagaacc ugcugcacgu gaccgacacc ggcgugggca ugaccagaga ggagcuggug      480

aagaaccugg gcaccaucgc caagagcggc accagcgagu uccugaacaa gaugaccgag      540

gcccaggagg acggccagag caccagcgag cugaucggcc aguucggcgu gggcuucuac      600

agcgccuucc ugguggccga caaggugauc gugaccagca agcacaacaa cgacacccag      660

cacaucuggg agagcgacag caacgaguuc agcgugaucg ccgaccccag aggcaacacc      720

cugggcagag gcaccaccau cacccuggug cugaaggagg aggccagcga cuaccuggag      780

cuggacacca ucaagaaccu ggugaagaag uacagccagu ucaucaacuu ccccaucuac      840

guguggagca gcaagaccga gaccguggag gagcccaugg aggaggagga ggccgccaag      900

gaggagaagg aggagagcga cgacgaggcc gccguggagg aggaggagga ggagaagaag      960

cccaagacca agaaggugga gaagaccgug ugggacuggg agcugaugaa cgacaucaag     1020

cccaucuggc agagacccag caaggaggug gaggaggacg aguacaaggc cuucuacaag     1080

agcuucagca aggagagcga cgaccccaug gccuacaucc acuucaccgc cgagggcgag     1140

gugaccuuca agagcauccu guucgugccc accagcgccc ccagaggccu guucgacgag     1200

uacggcagca agaagagcga cuacaucaag cuguacguga gaagaguguu caucaccgac     1260

gacuuccacg acaugaugcc caaguaccug aacuucguga agggcguggu ggacagcgac     1320

gaccugcccc ugaacgugag cagagagacc cugcagcagc acaagcugcu gaaggugauc     1380

agaaagaagc uggugagaaa gacccuggac augaucaaga agaucgccga cgacaaguac     1440

aacgacaccu ucuggaagga guucggcacc aacaucaagc ugggcgugau cgaggaccac     1500

agcaacagaa ccagacuggc caagcugcug agauuccaga gcagccacca ccccaccgac     1560

aucaccagcc uggaccagua cguggagaga augaaggaga agcaggacaa gaucuacuuc     1620

auggccggca gcagcagaaa ggaggccgag agcagccccu ucguggagag acugcugaag     1680

aagggcuacg aggugaucua ccugaccgag cccguggacg aguacugcau ccaggcccug     1740

cccgaguucg acggcaagag auuccagaac guggccaagg agggcgugaa guucgacgag     1800

agcgagaaga ccaaggagag cagagaggcc guggagaagg aguucgagcc ccugcugaac     1860

uggaugaagg acaaggcccu gaaggacaag aucgagaagg ccguggugag ccagagacug     1920

accgagagcc ccugcgcccu gguggccagc caguacggcu ggagcggcaa cauggagaga     1980

aucaugaagg cccaggccua ccagaccggc aaggacauca gcaccaacua cuacgccagc     2040

cagaagaaga ccuucgagau caaccccaga cacccccuga ucagagacau gcugagaaga     2100

aucaaggagg acgaggacga caagaccgug cuggaccugg ccguggugcu guucgagacc     2160

gccacccuga gaagcggcua ccugcugccc gacaccaagg ccuacggcga cagaaucgag     2220

agaaugcuga gacugagccu gaacaucgac cccgacgcca agguggagga ggagcccgag     2280

gaggagcccg aggagaccgc cgaggacacc accgaggaca ccgagcagga cgaggacgag     2340

gagauggacg ugggcaccga cgaggaggag accgccaagg agagcaccgc cgagaaggac     2400

gagcuguga                                                             2409


<210>  8639
<211>  2409
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       HSP90B1__Homo_sapiens__CAI64497

<400>  8639
augagagccc ugugggugcu cggccugugc uguguccuuc ugaccuucgg gagcguucgg       60

gcugacgaug agguggacgu ggauggaaca gucgaagagg accucggcaa gucccgcgaa      120

gggucuagaa cggaugacga ggugguucag cgggaagagg aggccaucca acuggaugga      180

cuuaacgcga gccagauucg cgaacugaga gagaaauccg aaaaguuugc uuuccaggcc      240

gaggugaauc ggaugaugaa acucaucauu aacucucugu acaagaauaa agagaucuuu      300

cugcgcgaac ucauuagcaa cgccuccgac gcucuggaua agaucagacu uaucucucug      360

accgacgaga augcccucag cggcaacgaa gaacugacag ucaagauuaa augcgauaag      420

gagaaaaauc uucugcacgu gaccgacaca gggguuggaa ugacccggga ggagcucgug      480

aagaaccugg gcacaaucgc uaaauccggc accagcgagu uccugaauaa gaugacggag      540

gcccaggaag augggcaauc uaccuccgag cucauuggac aguuuggcgu cggguucuau      600

agcgcguuuc ugguggccga caaggugauc gucacaucua aacauaacaa ugacacccag      660

cacauuuggg aauccgauag caacgaguuc ucuguuaucg cugacccccg cggaaauaca      720

cuuggcagag ggaccacgau uacacuggug cucaaggagg aagccuccga uuaccuggag      780

cuugacacca ucaaaaaccu ggugaagaaa uauagccagu uuaucaauuu cccuauuuac      840

gucugguccu cuaagacaga aaccguggag gaaccgaugg aggaggaaga ggcugccaaa      900

gaagagaagg aggaaagcga ugacgaggcg gccguugaag aggaagagga ggaaaagaaa      960

cccaagacca aaaaggugga gaaaacaguc ugggauuggg aacucaugaa cgacaucaag     1020

ccuauuuggc aacggcccuc caaggaggug gaagaggaug aguauaaagc cuuuuacaag     1080

agcuucucua aagaauccga cgauccuaug gcuuauaucc auuuuacggc ugagggagaa     1140

guuaccuuca agagcauucu guucgugccc acaucugccc cucgcggccu guuugacgag     1200

uacggcagca aaaaguccga cuacaucaag cucuauguca gacggguguu caucaccgau     1260

gacuuucacg auaugaugcc gaaauaccug aacuucguca aggggguggu ugacucugau     1320

gaccuucccc ugaaugugag ccgcgaaaca cuccagcagc auaaacugcu uaaggucauu     1380

cggaaaaagc uggugagaaa gacccucgau augaucaaaa agauugccga cgauaaauau     1440

aacgacacgu uuuggaagga guucggaaca aauaucaaac ugggcguuau ugaggaucac     1500

uccaacagaa cccgccuggc uaagcuccug cgguuucaga gcucucacca uccuaccgac     1560

aucacauccc uugaucaaua cguggaaaga augaaagaga agcaggacaa gaucuauuuc     1620

auggcgggga gcucucgcaa agaagccgag uccagccccu uugucgagcg gcugcucaag     1680

aaaggauacg aagugauuua ucugaccgag ccuguggacg aauacuguau ccaggcucug     1740

cccgaguucg auggcaagag auuucaaaau guugccaaag aaggggucaa guucgacgag     1800

uccgagaaga caaaagaauc ucgcgaggcc guggaaaagg aguuugaacc gcuucucaac     1860

uggaugaaag auaaggcucu gaaagacaag auugagaagg ccguggucag ccagcggcug     1920

acggaguccc cuugcgcgcu cguggcuucu caguacggau ggagcggcaa uauggaaaga     1980

aucaugaaag cccaggccua ucaaaccggc aaggauauuu ccacaaacua cuaugcuagc     2040

cagaaaaaga ccuucgagau caauccccgc cacccucuga uucgggacau gcuuagacgc     2100

aucaaagaag augaggacga uaagacaguu cuggaccucg ccgugguccu guucgaaacc     2160

gcuacgcugc ggucugggua ccuucucccc gauaccaagg ccuauggaga cagaaucgag     2220

cggaugcugc gccugucccu caacauugau cccgacgcga aaguggagga agaaccugaa     2280

gaggagccgg aagagacagc cgaagacacc acagaggaua ccgaacagga cgaggaugag     2340

gaaauggacg uuggcacgga ugaggaagag acagcuaagg aaagcaccgc cgagaaagac     2400

gagcuguga                                                             2409


<210>  8640
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__O14920

<400>  8640

Met Ser Trp Ser Pro Ser Leu Thr Thr Gln Thr Cys Gly Ala Trp Glu 
1               5                   10                  15      


Met Lys Glu Arg Leu Gly Thr Gly Gly Phe Gly Asn Val Ile Arg Trp 
            20                  25                  30          


His Asn Gln Glu Thr Gly Glu Gln Ile Ala Ile Lys Gln Cys Arg Gln 
        35                  40                  45              


Glu Leu Ser Pro Arg Asn Arg Glu Arg Trp Cys Leu Glu Ile Gln Ile 
    50                  55                  60                  


Met Arg Arg Leu Thr His Pro Asn Val Val Ala Ala Arg Asp Val Pro 
65                  70                  75                  80  


Glu Gly Met Gln Asn Leu Ala Pro Asn Asp Leu Pro Leu Leu Ala Met 
                85                  90                  95      


Glu Tyr Cys Gln Gly Gly Asp Leu Arg Lys Tyr Leu Asn Gln Phe Glu 
            100                 105                 110         


Asn Cys Cys Gly Leu Arg Glu Gly Ala Ile Leu Thr Leu Leu Ser Asp 
        115                 120                 125             


Ile Ala Ser Ala Leu Arg Tyr Leu His Glu Asn Arg Ile Ile His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Glu Asn Ile Val Leu Gln Gln Gly Glu Gln Arg Leu 
145                 150                 155                 160 


Ile His Lys Ile Ile Asp Leu Gly Tyr Ala Lys Glu Leu Asp Gln Gly 
                165                 170                 175     


Ser Leu Cys Thr Ser Phe Val Gly Thr Leu Gln Tyr Leu Ala Pro Glu 
            180                 185                 190         


Leu Leu Glu Gln Gln Lys Tyr Thr Val Thr Val Asp Tyr Trp Ser Phe 
        195                 200                 205             


Gly Thr Leu Ala Phe Glu Cys Ile Thr Gly Phe Arg Pro Phe Leu Pro 
    210                 215                 220                 


Asn Trp Gln Pro Val Gln Trp His Ser Lys Val Arg Gln Lys Ser Glu 
225                 230                 235                 240 


Val Asp Ile Val Val Ser Glu Asp Leu Asn Gly Thr Val Lys Phe Ser 
                245                 250                 255     


Ser Ser Leu Pro Tyr Pro Asn Asn Leu Asn Ser Val Leu Ala Glu Arg 
            260                 265                 270         


Leu Glu Lys Trp Leu Gln Leu Met Leu Met Trp His Pro Arg Gln Arg 
        275                 280                 285             


Gly Thr Asp Pro Thr Tyr Gly Pro Asn Gly Cys Phe Lys Ala Leu Asp 
    290                 295                 300                 


Asp Ile Leu Asn Leu Lys Leu Val His Ile Leu Asn Met Val Thr Gly 
305                 310                 315                 320 


Thr Ile His Thr Tyr Pro Val Thr Glu Asp Glu Ser Leu Gln Ser Leu 
                325                 330                 335     


Lys Ala Arg Ile Gln Gln Asp Thr Gly Ile Pro Glu Glu Asp Gln Glu 
            340                 345                 350         


Leu Leu Gln Glu Ala Gly Leu Ala Leu Ile Pro Asp Lys Pro Ala Thr 
        355                 360                 365             


Gln Cys Ile Ser Asp Gly Lys Leu Asn Glu Gly His Thr Leu Asp Met 
    370                 375                 380                 


Asp Leu Val Phe Leu Phe Asp Asn Ser Lys Ile Thr Tyr Glu Thr Gln 
385                 390                 395                 400 


Ile Ser Pro Arg Pro Gln Pro Glu Ser Val Ser Cys Ile Leu Gln Glu 
                405                 410                 415     


Pro Lys Arg Asn Leu Ala Phe Phe Gln Leu Arg Lys Val Trp Gly Gln 
            420                 425                 430         


Val Trp His Ser Ile Gln Thr Leu Lys Glu Asp Cys Asn Arg Leu Gln 
        435                 440                 445             


Gln Gly Gln Arg Ala Ala Met Met Asn Leu Leu Arg Asn Asn Ser Cys 
    450                 455                 460                 


Leu Ser Lys Met Lys Asn Ser Met Ala Ser Met Ser Gln Gln Leu Lys 
465                 470                 475                 480 


Ala Lys Leu Asp Phe Phe Lys Thr Ser Ile Gln Ile Asp Leu Glu Lys 
                485                 490                 495     


Tyr Ser Glu Gln Thr Glu Phe Gly Ile Thr Ser Asp Lys Leu Leu Leu 
            500                 505                 510         


Ala Trp Arg Glu Met Glu Gln Ala Val Glu Leu Cys Gly Arg Glu Asn 
        515                 520                 525             


Glu Val Lys Leu Leu Val Glu Arg Met Met Ala Leu Gln Thr Asp Ile 
    530                 535                 540                 


Val Asp Leu Gln Arg Ser Pro Met Gly Arg Lys Gln Gly Gly Thr Leu 
545                 550                 555                 560 


Asp Asp Leu Glu Glu Gln Ala Arg Glu Leu Tyr Arg Arg Leu Arg Glu 
                565                 570                 575     


Lys Pro Arg Asp Gln Arg Thr Glu Gly Asp Ser Gln Glu Met Val Arg 
            580                 585                 590         


Leu Leu Leu Gln Ala Ile Gln Ser Phe Glu Lys Lys Val Arg Val Ile 
        595                 600                 605             


Tyr Thr Gln Leu Ser Lys Thr Val Val Cys Lys Gln Lys Ala Leu Glu 
    610                 615                 620                 


Leu Leu Pro Lys Val Glu Glu Val Val Ser Leu Met Asn Glu Asp Glu 
625                 630                 635                 640 


Lys Thr Val Val Arg Leu Gln Glu Lys Arg Gln Lys Glu Leu Trp Asn 
                645                 650                 655     


Leu Leu Lys Ile Ala Cys Ser Lys Val Arg Gly Pro Val Ser Gly Ser 
            660                 665                 670         


Pro Asp Ser Met Asn Ala Ser Arg Leu Ser Gln Pro Gly Gln Leu Met 
        675                 680                 685             


Ser Gln Pro Ser Thr Ala Ser Asn Ser Leu Pro Glu Pro Ala Lys Lys 
    690                 695                 700                 


Ser Glu Glu Leu Val Ala Glu Ala His Asn Leu Cys Thr Leu Leu Glu 
705                 710                 715                 720 


Asn Ala Ile Gln Asp Thr Val Arg Glu Gln Asp Gln Ser Phe Thr Ala 
                725                 730                 735     


Leu Asp Trp Ser Trp Leu Gln Thr Glu Glu Glu Glu His Ser Cys Leu 
            740                 745                 750         


Glu Gln Ala Ser 
        755     


<210>  8641
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__AAD08997

<400>  8641
augagcuggu caccuucccu gacaacgcag acaugugggg ccugggaaau gaaagagcgc       60

cuugggacag ggggauuugg aaaugucauc cgauggcaca aucaggaaac aggugagcag      120

auugccauca agcagugccg gcaggagcuc agcccccgga accgagagcg guggugccug      180

gagauccaga ucaugagaag gcugacccac cccaaugugg uggcugcccg agaugucccu      240

gaggggaugc agaacuuggc gcccaaugac cugccccugc uggccaugga guacugccaa      300

ggaggagauc uccggaagua ccugaaccag uuugagaacu gcuguggucu gcgggaaggu      360

gccauccuca ccuugcugag ugacauugcc ucugcgcuua gauaccuuca ugaaaacaga      420

aucauccauc gggaucuaaa gccagaaaac aucguccugc agcaaggaga acagagguua      480

auacacaaaa uuauugaccu aggauaugcc aaggagcugg aucagggcag ucuuugcaca      540

ucauucgugg ggacccugca guaccuggcc ccagagcuac uggagcagca gaaguacaca      600

gugaccgucg acuacuggag cuucggcacc cuggccuuug agugcaucac gggcuuccgg      660

cccuuccucc ccaacuggca gcccgugcag uggcauucaa aagugcggca gaagagugag      720

guggacauug uuguuagcga agacuugaau ggaacgguga aguuuucaag cucuuuaccc      780

uaccccaaua aucuuaacag uguccuggcu gagcgacugg agaaguggcu gcaacugaug      840

cugauguggc acccccgaca gaggggcacg gaucccacgu augggcccaa uggcugcuuc      900

aaggcccugg augacaucuu aaacuuaaag cugguucaua ucuugaacau ggucacgggc      960

accauccaca ccuacccugu gacagaggau gagagucugc agagcuugaa ggccagaauc     1020

caacaggaca cgggcauccc agaggaggac caggagcugc ugcaggaagc gggccuggcg     1080

uugauccccg auaagccugc cacucagugu auuucagacg gcaaguuaaa ugagggccac     1140

acauuggaca uggaucuugu uuuucucuuu gacaacagua aaaucaccua ugagacucag     1200

aucuccccac ggccccaacc ugaaaguguc agcuguaucc uucaagagcc caagaggaau     1260

cucgccuucu uccagcugag gaaggugugg ggccaggucu ggcacagcau ccagacccug     1320

aaggaagauu gcaaccggcu gcagcaggga cagcgagccg ccaugaugaa ucuccuccga     1380

aacaacagcu gccucuccaa aaugaagaau uccauggcuu ccaugucuca gcagcucaag     1440

gccaaguugg auuucuucaa aaccagcauc cagauugacc uggagaagua cagcgagcaa     1500

accgaguuug ggaucacauc agauaaacug cugcuggccu ggagggaaau ggagcaggcu     1560

guggagcucu gugggcggga gaacgaagug aaacuccugg uagaacggau gauggcucug     1620

cagaccgaca uuguggacuu acagaggagc cccaugggcc ggaagcaggg gggaacgcug     1680

gacgaccuag aggagcaagc aagggagcug uacaggagac uaagggaaaa accucgagac     1740

cagcgaacug agggugacag ucaggaaaug guacggcugc ugcuucaggc aauucagagc     1800

uucgagaaga aagugcgagu gaucuauacg cagcucagua aaacuguggu uugcaagcag     1860

aaggcgcugg aacuguugcc caagguggaa gaggugguga gcuuaaugaa ugaggaugag     1920

aagacuguug uccggcugca ggagaagcgg cagaaggagc ucuggaaucu ccugaagauu     1980

gcuuguagca agguccgugg uccugucagu ggaagcccgg auagcaugaa ugccucucga     2040

cuuagccagc cugggcagcu gaugucucag cccuccacgg ccuccaacag cuuaccugag     2100

ccagccaaga agagugaaga acugguggcu gaagcacaua accucugcac ccugcuagaa     2160

aaugccauac aggacacugu gagggaacaa gaccagaguu ucacggcccu agacuggagc     2220

ugguuacaga cggaagaaga agagcacagc ugccuggagc aggccucaug a              2271


<210>  8642
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IKK__Homo_sapiens__AAD08997

<400>  8642
augagcuggu cccccagccu gaccacccag acgugcggcg ccugggagau gaaggagcgc       60

cucgggaccg gcggguucgg caacgugauc cgguggcaca accaggagac cggggagcag      120

aucgccauca agcagugccg ccaggagcug uccccgcgga accgcgagcg guggugccug      180

gagauccaga ucaugcgccg gcucacccac cccaacgucg uggcggcccg cgacgugccc      240

gagggcaugc agaaccuggc ccccaacgac cugccgcucc uggccaugga guacugccag      300

ggcggggacc ugcggaagua ccucaaccag uucgagaacu gcugcggccu gcgcgagggg      360

gccauccuga cgcuccugag cgacaucgcg uccgcccugc gguaccucca cgagaaccgc      420

aucauccacc gggaccugaa gcccgagaac aucguccugc agcagggcga gcagcgccuc      480

auccacaaga ucaucgaccu gggguacgcc aaggagcugg accagggcag ccucugcacc      540

uccuucgugg gcacccugca guaccuggcc cccgagcucc uggagcagca gaaguacacc      600

gugacggucg acuacuggag cuucgggacc cuggcguucg agugcaucac cggcuuccgg      660

cccuuccucc cgaacuggca gcccgugcag uggcacucca aggugcgcca gaaguccgag      720

gucgacaucg uggugagcga ggaccugaac gggaccguca aguucagcuc cagccugccc      780

uaccccaaca accucaacuc cgugcuggcc gagcggcugg agaaguggcu ccagcugaug      840

cugauguggc acccgcgcca gcggggcacg gaccccaccu acggccccaa cgggugcuuc      900

aaggcccucg acgacauccu gaaccugaag cucgugcaca uccugaacau ggucaccggc      960

accauccaca cguaccccgu gaccgaggac gagagccugc agucccucaa ggcccgcauc     1020

cagcaggaca ccgggauccc ggaggaggac caggagcugc ugcaggaggc cggccucgcg     1080

cugauccccg acaagcccgc cacccagugc aucagcgacg ggaagcugaa cgagggccac     1140

acgcucgaca uggaccuggu guuccuguuc gacaacucca agaucaccua cgagacccag     1200

aucagccccc ggccgcagcc cgagagcguc uccugcaucc ugcaggagcc caagcgcaac     1260

cucgccuucu uccagcugcg caaggugugg ggccaggugu ggcacagcau ccagacccug     1320

aaggaggacu gcaaccggcu ccagcagggg cagcgcgccg ccaugaugaa ccugcugcgg     1380

aacaacuccu gccucagcaa gaugaagaac uccauggcga gcauguccca gcagcugaag     1440

gccaagcugg acuucuucaa gacgagcauc cagaucgacc ucgagaagua cuccgagcag     1500

accgaguucg gcaucaccag cgacaagcug cugcucgccu ggcgcgagau ggagcaggcc     1560

gucgagcugu gcgggcggga gaacgaggug aagcugcucg uggagcgcau gauggcccug     1620

cagaccgaca ucgucgaccu gcagcggucc cccaugggcc gcaagcaggg cgggacgcuc     1680

gacgaccugg aggagcaggc gcgggagcug uaccgccggc uccgcgagaa gccgcgggac     1740

cagcgcaccg agggcgacag ccaggagaug gugcggcugc ugcuccaggc cauccagucc     1800

uucgagaaga agguccgcgu gaucuacacc cagcugagca agaccguggu cugcaagcag     1860

aaggcccugg agcuccugcc caagguggag gagguggucu cccugaugaa cgaggacgag     1920

aagacggugg ugcggcucca ggagaagcgc cagaaggagc uguggaaccu gcucaagauc     1980

gccugcagca agguccgggg gcccgugucc ggcagccccg acuccaugaa cgccagccgc     2040

cugagccagc cggggcagcu gaugucccag cccagcaccg cguccaacag ccuccccgag     2100

ccggccaaga aguccgagga gcugguggcc gaggcccaca accugugcac ccuccuggag     2160

aacgcgaucc aggacaccgu ccgcgagcag gaccagagcu ucacggcccu ggacuggucc     2220

uggcuccaga ccgaggagga ggagcacagc ugccuggagc aggccuccug a              2271


<210>  8643
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IKK__Homo_sapiens__AAD08997

<400>  8643
auguccuggu cccccucccu caccacccag accugcggcg ccugggagau gaaggagcgc       60

cucggcaccg gcggcuucgg caacgucauc cgcuggcaca accaggagac cggcgagcag      120

aucgccauca agcagugccg ccaggagcuc uccccccgca accgcgagcg cuggugccuc      180

gagauccaga ucaugcgccg ccucacccac cccaacgucg ucgccgcccg cgacgucccc      240

gagggcaugc agaaccucgc ccccaacgac cucccccucc ucgccaugga guacugccag      300

ggcggcgacc uccgcaagua ccucaaccag uucgagaacu gcugcggccu ccgcgagggc      360

gccauccuca cccuccucuc cgacaucgcc uccgcccucc gcuaccucca cgagaaccgc      420

aucauccacc gcgaccucaa gcccgagaac aucguccucc agcagggcga gcagcgccuc      480

auccacaaga ucaucgaccu cggcuacgcc aaggagcucg accagggcuc ccucugcacc      540

uccuucgucg gcacccucca guaccucgcc cccgagcucc ucgagcagca gaaguacacc      600

gucaccgucg acuacugguc cuucggcacc cucgccuucg agugcaucac cggcuuccgc      660

cccuuccucc ccaacuggca gcccguccag uggcacucca agguccgcca gaaguccgag      720

gucgacaucg ucgucuccga ggaccucaac ggcaccguca aguucuccuc cucccucccc      780

uaccccaaca accucaacuc cguccucgcc gagcgccucg agaaguggcu ccagcucaug      840

cucauguggc acccccgcca gcgcggcacc gaccccaccu acggccccaa cggcugcuuc      900

aaggcccucg acgacauccu caaccucaag cucguccaca uccucaacau ggucaccggc      960

accauccaca ccuaccccgu caccgaggac gagucccucc agucccucaa ggcccgcauc     1020

cagcaggaca ccggcauccc cgaggaggac caggagcucc uccaggaggc cggccucgcc     1080

cucauccccg acaagcccgc cacccagugc aucuccgacg gcaagcucaa cgagggccac     1140

acccucgaca uggaccucgu cuuccucuuc gacaacucca agaucaccua cgagacccag     1200

aucucccccc gcccccagcc cgaguccguc uccugcaucc uccaggagcc caagcgcaac     1260

cucgccuucu uccagcuccg caaggucugg ggccaggucu ggcacuccau ccagacccuc     1320

aaggaggacu gcaaccgccu ccagcagggc cagcgcgccg ccaugaugaa ccuccuccgc     1380

aacaacuccu gccucuccaa gaugaagaac uccauggccu ccauguccca gcagcucaag     1440

gccaagcucg acuucuucaa gaccuccauc cagaucgacc ucgagaagua cuccgagcag     1500

accgaguucg gcaucaccuc cgacaagcuc cuccucgccu ggcgcgagau ggagcaggcc     1560

gucgagcucu gcggccgcga gaacgagguc aagcuccucg ucgagcgcau gauggcccuc     1620

cagaccgaca ucgucgaccu ccagcgcucc cccaugggcc gcaagcaggg cggcacccuc     1680

gacgaccucg aggagcaggc ccgcgagcuc uaccgccgcc uccgcgagaa gccccgcgac     1740

cagcgcaccg agggcgacuc ccaggagaug guccgccucc uccuccaggc cauccagucc     1800

uucgagaaga agguccgcgu caucuacacc cagcucucca agaccgucgu cugcaagcag     1860

aaggcccucg agcuccuccc caaggucgag gaggucgucu cccucaugaa cgaggacgag     1920

aagaccgucg uccgccucca ggagaagcgc cagaaggagc ucuggaaccu ccucaagauc     1980

gccugcucca agguccgcgg ccccgucucc ggcucccccg acuccaugaa cgccucccgc     2040

cucucccagc ccggccagcu caugucccag cccuccaccg ccuccaacuc ccuccccgag     2100

cccgccaaga aguccgagga gcucgucgcc gaggcccaca accucugcac ccuccucgag     2160

aacgccaucc aggacaccgu ccgcgagcag gaccaguccu ucaccgcccu cgacuggucc     2220

uggcuccaga ccgaggagga ggagcacucc ugccucgagc aggccuccug a              2271


<210>  8644
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IKK__Homo_sapiens__AAD08997

<400>  8644
augagcuggu cccccucucu gaccacacag acuugcggcg ccugggagau gaaggaaaga       60

cucgggacgg gagguuucgg caacgugauc agguggcaca aucaagagac cggggaacag      120

auugcuauaa aacagugucg gcaggagcuu ucaccucgca accgagaacg uuggugccug      180

gagauccaaa uuaugagaag guugacacau ccaaaugucg uugcagcccg ggacgugccg      240

gagggaaugc agaacuuagc gcccaaugau cugccucuac ucgcuaugga auacugucag      300

ggcggugacc ugcgcaagua ucuuaaccag uuugagaauu gcugugggcu gagagaagga      360

gccaucuuga cucuccugag ugauauugca agcgcccuga gguaccucca cgagaaccgg      420

aucauacauc gcgacuuaaa accagagaau aucguacugc aacagggcga acagcgacuu      480

auucacaaga ucauugauuu gggcuaugcu aaagagcugg accagggguc ccuaugcacc      540

ucuuucgugg gaacacucca auaccuggca cccgaacuuc uggagcagca gaaguauacc      600

gucacugugg auuacugguc guuugguaca uuggccuucg aauguaucac cggcuuuaga      660

ccuuuccucc caaacuggca acccguucag uggcauucaa aggugaggca gaaaagcgag      720

gucgacauag ugguaaguga ggaucugaau gggacgguua aguuuuccuc uagcuuaccu      780

uauccaaaca aucugaacuc cgugcucgcu gaacggcuug agaaauggcu gcaguugaug      840

cuaauguggc acccgcguca acgcggaacu gaccccaccu acggcccuaa ugguugcuuc      900

aaggcccugg augacauucu caaccugaaa cuuguccaca uccugaacau ggugacaggg      960

acuauucaua ccuacccagu gacagaagau gagucauugc agagucucaa ggcgagaauc     1020

cagcaggaca ccggaauccc cgaagaggac caagagcugu uacaggaagc aggccuggcc     1080

cuaauuccug auaagccagc uacgcagugu auaagcgacg gcaaacucaa ugaggggcac     1140

acucuggaua uggaccuugu cuuuuuguuc gauaacucua agaucacaua ugaaacccag     1200

auuuccccca ggccgcaacc ugagucaguu agcugcaucc ugcaggaacc caaacggaau     1260

cucgccuuuu uccagcugcg aaaggugugg ggacagguau ggcauaguau acaaacucuu     1320

aaagaggacu guaaccgccu gcagcagggu caaagagcag cuaugaugaa uuugcucagg     1380

aacaauucuu gccuguccaa gaugaaaaac agcauggccu cgaugucuca gcaguuaaag     1440

gcgaagcugg acuuuuucaa aacauccauu cagaucgauc uagagaagua cucagaacaa     1500

accgaguucg gcaucacgag ugauaaacuc cugcuugccu ggcgggaaau ggagcaggca     1560

guggaguugu gcgggcgcga aaaugagguc aagcugcucg uggaaagaau gauggcucug     1620

cagaccgaca uuguugauuu acagaggagc ccaaugggac guaaacaagg cgguacacug     1680

gacgaccuug aggaacaggc ccgggaguug uaucgaagac ucagggagaa gccucgcgau     1740

cagcggacug aaggggacuc ccaggagaug gugagacugc uacugcaagc uauccagucu     1800

uuugaaaaga aagucagggu gauuuacacc cagcucagca agacaguagu uuguaaacaa     1860

aaggcccugg agcuuuugcc caaaguggaa gaggucgugu cacugaugaa cgaggaugaa     1920

aagacugucg ugcgcuuaca ggagaagcga cagaaagaac ucuggaaucu gcuuaagaua     1980

gcaugcagua aaguucgggg cccagugucc ggaagccccg acucuaugaa cgccucacgu     2040

cugagucagc cuggccaauu gaugagccag ccauccaccg cuucuaauuc gcucccggag     2100

cccgcgaaga aaagcgagga acugguagca gaggcccaca accuauguac acugcucgaa     2160

aaugcuaucc aggauaccgu cagagagcag gaccaauccu ucacugcccu ggauugguca     2220

uggcuucaga cggaagagga ggaacacagu ugcuuggagc aggcaucuug a              2271


<210>  8645
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IKK__Homo_sapiens__AAD08997

<400>  8645
augagcugga gccccagccu gaccacccag accugcggcg ccugggagau gaaggagaga       60

cugggcaccg gcggcuucgg caacgugauc agauggcaca accaggagac cggcgagcag      120

aucgccauca agcagugcag acaggagcug agccccagaa acagagagag auggugccug      180

gagauccaga ucaugagaag acugacccac cccaacgugg uggccgccag agacgugccc      240

gagggcaugc agaaccuggc ccccaacgac cugccccugc uggccaugga guacugccag      300

ggcggcgacc ugagaaagua ccugaaccag uucgagaacu gcugcggccu gagagagggc      360

gccauccuga cccugcugag cgacaucgcc agcgcccuga gauaccugca cgagaacaga      420

aucauccaca gagaccugaa gcccgagaac aucgugcugc agcagggcga gcagagacug      480

auccacaaga ucaucgaccu gggcuacgcc aaggagcugg accagggcag ccugugcacc      540

agcuucgugg gcacccugca guaccuggcc cccgagcugc uggagcagca gaaguacacc      600

gugaccgugg acuacuggag cuucggcacc cuggccuucg agugcaucac cggcuucaga      660

cccuuccugc ccaacuggca gcccgugcag uggcacagca aggugagaca gaagagcgag      720

guggacaucg uggugagcga ggaccugaac ggcaccguga aguucagcag cagccugccc      780

uaccccaaca accugaacag cgugcuggcc gagagacugg agaaguggcu gcagcugaug      840

cugauguggc accccagaca gagaggcacc gaccccaccu acggccccaa cggcugcuuc      900

aaggcccugg acgacauccu gaaccugaag cuggugcaca uccugaacau ggugaccggc      960

accauccaca ccuaccccgu gaccgaggac gagagccugc agagccugaa ggccagaauc     1020

cagcaggaca ccggcauccc cgaggaggac caggagcugc ugcaggaggc cggccuggcc     1080

cugauccccg acaagcccgc cacccagugc aucagcgacg gcaagcugaa cgagggccac     1140

acccuggaca uggaccuggu guuccuguuc gacaacagca agaucaccua cgagacccag     1200

aucagcccca gaccccagcc cgagagcgug agcugcaucc ugcaggagcc caagagaaac     1260

cuggccuucu uccagcugag aaaggugugg ggccaggugu ggcacagcau ccagacccug     1320

aaggaggacu gcaacagacu gcagcagggc cagagagccg ccaugaugaa ccugcugaga     1380

aacaacagcu gccugagcaa gaugaagaac agcauggcca gcaugagcca gcagcugaag     1440

gccaagcugg acuucuucaa gaccagcauc cagaucgacc uggagaagua cagcgagcag     1500

accgaguucg gcaucaccag cgacaagcug cugcuggccu ggagagagau ggagcaggcc     1560

guggagcugu gcggcagaga gaacgaggug aagcugcugg uggagagaau gauggcccug     1620

cagaccgaca ucguggaccu gcagagaagc cccaugggca gaaagcaggg cggcacccug     1680

gacgaccugg aggagcaggc cagagagcug uacagaagac ugagagagaa gcccagagac     1740

cagagaaccg agggcgacag ccaggagaug gugagacugc ugcugcaggc cauccagagc     1800

uucgagaaga aggugagagu gaucuacacc cagcugagca agaccguggu gugcaagcag     1860

aaggcccugg agcugcugcc caagguggag gaggugguga gccugaugaa cgaggacgag     1920

aagaccgugg ugagacugca ggagaagaga cagaaggagc uguggaaccu gcugaagauc     1980

gccugcagca aggugagagg ccccgugagc ggcagccccg acagcaugaa cgccagcaga     2040

cugagccagc ccggccagcu gaugagccag cccagcaccg ccagcaacag ccugcccgag     2100

cccgccaaga agagcgagga gcugguggcc gaggcccaca accugugcac ccugcuggag     2160

aacgccaucc aggacaccgu gagagagcag gaccagagcu ucaccgcccu ggacuggagc     2220

uggcugcaga ccgaggagga ggagcacagc ugccuggagc aggccagcug a              2271


<210>  8646
<211>  2271
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IKK__Homo_sapiens__AAD08997

<400>  8646
augagcuggu cccccucucu gaccacacag acgugcggcg ccugggagau gaaggaaaga       60

cucgggaccg gaggcuucgg gaacgugauc cgguggcaca aucaagagac aggagaacag      120

auugcuauca aacagugucg ccaggagcug agcccuagaa accgggaacg cuggugccuu      180

gagauucaaa ucaugagacg gcugacccau ccgaaugucg uugccgcgcg cgacgugccc      240

gagggcaugc agaaccucgc uccuaaugau cugccccuuc uggccaugga auacugucag      300

ggaggagacc ucagaaagua ucugaaccag uuugagaauu gcuguggccu gcgggaaggc      360

gccauucuca cacugcuuuc cgauaucgcu ucugcccugc gcuaccucca cgagaacaga      420

aucauucauc gggaccugaa accugagaau aucgugcuuc aacaggggga acagcgccug      480

auucacaaga ucauugaucu cggauaugcu aaagagcugg accagggcag ccugugcacc      540

uccuucgucg ggacacucca auaccuggcc cccgaacuuc uggagcagca gaaguauacc      600

gugacgguug auuacugguc uuuuggaacc cucgcguucg aauguaucac aggcuuuaga      660

ccuuuccugc cgaacuggca acccgugcag uggcauagca agguccggca gaaauccgag      720

guggacauug uugugagcga ggaucuuaau gggaccguca aguuuucuuc cagccugccu      780

uaucccaaca aucucaacuc ugugcuggcc gaacgccugg agaaauggcu ccagcugaug      840

cuuauguggc acccuagaca acggggaaca gaccccaccu acggcccgaa uggcugcuuc      900

aaggcucugg augacauccu caaccugaaa cuugugcaca uccugaacau ggucacgggg      960

acaauucaua ccuacccugu uacagaagau gagucccucc agagccugaa ggccagaauc     1020

cagcaggaca ccgggauucc cgaagaggac caagagcugc uccaggaagc uggccuggcc     1080

cuuaucccug auaagcccgc gacccagugu auuucugacg ggaaacugaa ugagggacac     1140

acacucgaua uggaccuggu guuucuguuc gauaacucca agaucacgua ugaaacccag     1200

aucagccccc gcccucaacc ggaguccgug ucuugcauuc uucaggaacc caaacggaau     1260

cucgccuuuu uccagcugag aaaggucugg ggccaggugu ggcauagcau ccaaacacug     1320

aaagaggacu guaaccgccu ccagcagggg caacgggcug ccaugaugaa ucugcuuaga     1380

aacaauuccu gccugagcaa gaugaaaaac ucuauggcuu ccaugagcca gcagcucaag     1440

gccaagcugg acuuuuucaa aaccucuauu cagaucgauc uggagaagua cagcgaacaa     1500

acagaguucg gaauuaccuc cgauaaacuu cuccuggccu ggcgcgaaau ggagcaggcu     1560

guugagcugu gcggccggga aaaugaggug aagcuccugg ucgaaagaau gauggcgcuu     1620

cagacggaca ucguggaucu gcagcgcucu ccuaugggcc ggaaacaagg gggaacacuc     1680

gacgaccugg aggaacaggc cagagagcug uaucgccggc uuagagagaa gccccgggau     1740

cagcgcaccg aaggcgacag ccaggagaug guuagacucc ugcugcaagc uauccagucc     1800

uuugaaaaga aagugcgggu cauuuacacc cagcucagca agacaguggu cuguaaacaa     1860

aaggcccugg agcuucugcc uaaaguggaa gagguugugu cucucaugaa cgaggaugaa     1920

aagaccgucg ugagacugca ggagaagcgc cagaaagaac uguggaaucu ucucaagauc     1980

gccugcucca aaguucgggg gcccgugagc ggaucuccgg acuccaugaa cgcuagcaga     2040

cugucccagc cuggccaacu gaugucucag cccagcacag ccuccaauuc ucucccugag     2100

cccgcgaaga aaagcgagga acuggucgcu gaggcccaca accuuuguac gcugcucgaa     2160

aaugccauuc aggauaccgu gcgcgagcag gaccaauccu ucacagcucu ggauuggagc     2220

uggcugcaga ccgaagagga ggaacacucu ugccuugagc aggccuccug a              2271


<210>  8647
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__Q14164

<400>  8647

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Leu Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp 
                645                 650                 655     


Arg Ala Lys Gly Ala Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro 
            660                 665                 670         


Ser Pro Thr Arg Lys Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu 
        675                 680                 685             


Gly Met Lys Leu Leu Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile 
    690                 695                 700                 


Glu Arg Leu Asn Arg Val Pro Ala Pro Pro Asp Val 
705                 710                 715     


<210>  8648
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__AAF45307

<400>  8648
augcagagca cagccaauua ccuguggcac acagaugacc ugcuggggca gggggccacu       60

gccagugugu acaaggcccg caacaagaaa uccggagagc ugguugcugu gaaggucuuc      120

aacacuacca gcuaccugcg gccccgcgag gugcagguga gggaguuuga gguccugcgg      180

aagcugaacc accagaacau cgucaagcuc uuugcggugg aggagacggg cggaagccgg      240

cagaagguac uggugaugga guacugcucc agugggagcc ugcugagugu gcuggagagc      300

ccugagaaug ccuuugggcu gccugaggau gaguuccugg uggugcugcg cuguguggug      360

gccggcauga accaccugcg ggagaacggc auugugcauc gcgacaucaa gccggggaac      420

aucaugcgcc ucguagggga ggaggggcag agcaucuaca agcugacaga cuucggcgcu      480

gcccgggagc uggaugauga ugagaaguuc gucucggucu augggacuga ggaguaccug      540

caucccgaca uguaugagcg ggcggugcuu cgaaagcccc agcaaaaagc guucggggug      600

acuguggauc ucuggagcau uggagugacc uuguaccaug cagccacugg cagccugccc      660

uucauccccu uuggugggcc acggcggaac aaggagauca uguaccggau caccacggag      720

aagccggcug gggccauugc aggugcccag aggcgggaga acgggccccu ggaguggagc      780

uacacccucc ccaucaccug ccagcuguca cuggggcugc agagccagcu ggugcccauc      840

cuggccaaca uccuggaggu ggagcaggcc aagugcuggg gcuucgacca guucuuugcg      900

gagaccagug acauccugca gcgaguuguc guccaugucu ucucccuguc ccaggcaguc      960

cugcaccaca ucuauaucca ugcccacaac acgauagcca uuuuccagga ggccgugcac     1020

aagcagacca guguggcccc ccgacaccag gaguaccucu uugaggguca ccucuguguc     1080

cucgagccca gcgucucagc acagcacauc gcccacacga cggcaagcag cccccugacc     1140

cucuucagca cagccauccc uaaggggcug gccuucaggg acccugcucu ggacgucccc     1200

aaguucgucc ccaaagugga ccugcaggcg gauuacaaca cugccaaggg cguguugggc     1260

gccggcuacc aggcccugcg gcuggcacgg gcccugcugg augggcagga gcuaauguuu     1320

cgggggcugc acugggucau ggaggugcuc caggccacau gcagacggac ucuggaagug     1380

gcaaggacau cccuccucua ccucagcagc agccugggaa cugagagguu cagcagcgug     1440

gcuggaacgc cugagaucca ggaacugaag gcggcugcag aacugagguc caggcugcgg     1500

acucuagcgg agguccucuc cagaugcucc caaaauauca cggagaccca ggagagccug     1560

agcagccuga accgggagcu ggugaagagc cgggaucagg uacaugagga cagaagcauc     1620

cagcagauuc agugcuguuu ggacaagaug aacuucaucu acaaacaguu caagaagucu     1680

aggaugaggc cagggcuugg cuacaacgag gagcagauuc acaagcugga uaaggugaau     1740

uucagucauu uagccaaaag acuccugcag guguuccagg aggagugcgu gcagaaguau     1800

caagcguccu uagucacaca cggcaagagg augagggugg ugcacgagac caggaaccac     1860

cugcgccugg uuggcuguuc uguggcugcc uguaacacag aagcccaggg gguccaggag     1920

agucucagca agcuccugga agagcuaucu caccagcucc uucaggaccg agcaaagggg     1980

gcucaggccu cgccgccucc cauagcuccu uaccccagcc cuacacgaaa ggaccugcuu     2040

cuccacaugc aagagcucug cgaggggaug aagcugcugg caucugaccu ccuggacaac     2100

aaccgcauca ucgaacggcu aaauagaguc ccagcaccuc cugaugucug a              2151


<210>  8649
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IKK__Homo_sapiens__AAF45307

<400>  8649
augcagagca ccgccaacua ccuguggcac accgacgacc uccugggcca gggggccacg       60

gcguccgugu acaaggcccg caacaagaag uccggcgagc uggucgccgu gaagguguuc      120

aacaccaccu ccuaccuccg gccccgcgag guccaggugc gggaguucga ggugcugcgc      180

aagcugaacc accagaacau cgucaagcug uucgccgugg aggagaccgg gggcagccgg      240

cagaaggugc uggucaugga guacugcucc agcggguccc ugcucagcgu gcuggagucc      300

cccgagaacg ccuucggccu gcccgaggac gaguuccucg ugguccugcg cugcguggug      360

gcgggcauga accaccuccg ggagaacggg aucguccacc gcgacaucaa gcccggcaac      420

aucaugcggc ucguggggga ggagggccag agcaucuaca agcugacgga cuucggggcc      480

gcccgcgagc uggacgacga cgagaaguuc guguccgucu acggcaccga ggaguaccuc      540

caccccgaca uguacgagcg ggccgugcug cgcaagccgc agcagaaggc guucggcgug      600

accgucgacc uguggagcau cggggugacc cucuaccacg ccgccacggg cucccugccc      660

uucauccccu ucgggggccc ccggcgcaac aaggagauca uguaccggau caccaccgag      720

aagccggccg gcgccaucgc gggggcccag cgccgggaga acggcccccu ggaguggagc      780

uacacccucc ccaucacgug ccagcugucc cuggggcucc agagccagcu ggugcccauc      840

cuggccaaca uccucgaggu cgagcaggcc aagugcuggg gcuucgacca guucuucgcc      900

gagaccuccg acauccugca gcgcgugguc gugcacgugu ucagccuguc ccaggcgguc      960

cuccaccaca ucuacaucca cgcccacaac accaucgcca ucuuccagga ggccgugcac     1020

aagcagacca gcguggcccc gcggcaccag gaguaccugu ucgaggggca ccugugcguc     1080

cucgagccca gcguguccgc gcagcacauc gcccacacga ccgccagcag cccccugacc     1140

cuguucagca ccgccauccc caagggccuc gccuuccgcg acccggcgcu ggacgugccc     1200

aaguucgucc ccaaggugga ccugcaggcc gacuacaaca cggccaaggg cgugcucggg     1260

gccggcuacc aggcgcugcg gcuggcccgc gcccuccugg acgggcagga gcugauguuc     1320

cgcggccucc acugggucau ggaggugcug caggcgaccu gccggcgcac ccuggaggug     1380

gcccggaccu cccugcucua ccugagcucc agccugggga cggagcgcuu cuccagcguc     1440

gccggcaccc ccgagaucca ggagcucaag gccgccgccg agcugcgguc ccgccugcgg     1500

acccucgccg aggugcugag ccgcugcucc cagaacauca ccgagacgca ggagagccug     1560

uccagccuca accgggagcu ggugaagucc cgcgaccagg uccacgagga ccggagcauc     1620

cagcagaucc agugcugccu ggacaagaug aacuucaucu acaagcaguu caagaagucc     1680

cgcaugcggc cgggccucgg guacaacgag gagcagaucc acaagcugga caaggugaac     1740

uucagccacc uggcgaagcg ccuccugcag gucuuccagg aggagugcgu gcagaaguac     1800

caggccagcc uggugaccca cggcaagcgg augcgcgugg uccacgagac ccggaaccac     1860

cuccgccugg uggggugcuc cguggccgcc ugcaacaccg aggcccaggg cguccaggag     1920

agccugucca agcuccugga ggagcugagc caccagcucc ugcaggaccg ggcgaagggg     1980

gcccaggcca gcccgccgcc caucgccccc uaccccuccc ccacgcgcaa ggaccugcuc     2040

cugcacaugc aggagcugug cgagggcaug aagcuccugg cguccgaccu gcucgacaac     2100

aaccgcauca ucgagcggcu gaaccgcgug cccgccccgc ccgacgugug a              2151


<210>  8650
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IKK__Homo_sapiens__AAF45307

<400>  8650
augcagucca ccgccaacua ccucuggcac accgacgacc uccucggcca gggcgccacc       60

gccuccgucu acaaggcccg caacaagaag uccggcgagc ucgucgccgu caaggucuuc      120

aacaccaccu ccuaccuccg cccccgcgag guccaggucc gcgaguucga gguccuccgc      180

aagcucaacc accagaacau cgucaagcuc uucgccgucg aggagaccgg cggcucccgc      240

cagaaggucc ucgucaugga guacugcucc uccggcuccc uccucuccgu ccucgagucc      300

cccgagaacg ccuucggccu ccccgaggac gaguuccucg ucguccuccg cugcgucguc      360

gccggcauga accaccuccg cgagaacggc aucguccacc gcgacaucaa gcccggcaac      420

aucaugcgcc ucgucggcga ggagggccag uccaucuaca agcucaccga cuucggcgcc      480

gcccgcgagc ucgacgacga cgagaaguuc gucuccgucu acggcaccga ggaguaccuc      540

caccccgaca uguacgagcg cgccguccuc cgcaagcccc agcagaaggc cuucggcguc      600

accgucgacc ucugguccau cggcgucacc cucuaccacg ccgccaccgg cucccucccc      660

uucauccccu ucggcggccc ccgccgcaac aaggagauca uguaccgcau caccaccgag      720

aagcccgccg gcgccaucgc cggcgcccag cgccgcgaga acggcccccu cgaguggucc      780

uacacccucc ccaucaccug ccagcucucc cucggccucc agucccagcu cguccccauc      840

cucgccaaca uccucgaggu cgagcaggcc aagugcuggg gcuucgacca guucuucgcc      900

gagaccuccg acauccucca gcgcgucguc guccacgucu ucucccucuc ccaggccguc      960

cuccaccaca ucuacaucca cgcccacaac accaucgcca ucuuccagga ggccguccac     1020

aagcagaccu ccgucgcccc ccgccaccag gaguaccucu ucgagggcca ccucugcguc     1080

cucgagcccu ccgucuccgc ccagcacauc gcccacacca ccgccuccuc cccccucacc     1140

cucuucucca ccgccauccc caagggccuc gccuuccgcg accccgcccu cgacgucccc     1200

aaguucgucc ccaaggucga ccuccaggcc gacuacaaca ccgccaaggg cguccucggc     1260

gccggcuacc aggcccuccg ccucgcccgc gcccuccucg acggccagga gcucauguuc     1320

cgcggccucc acugggucau ggagguccuc caggccaccu gccgccgcac ccucgagguc     1380

gcccgcaccu cccuccucua ccucuccucc ucccucggca ccgagcgcuu cuccuccguc     1440

gccggcaccc ccgagaucca ggagcucaag gccgccgccg agcuccgcuc ccgccuccgc     1500

acccucgccg agguccucuc ccgcugcucc cagaacauca ccgagaccca ggagucccuc     1560

uccucccuca accgcgagcu cgucaagucc cgcgaccagg uccacgagga ccgcuccauc     1620

cagcagaucc agugcugccu cgacaagaug aacuucaucu acaagcaguu caagaagucc     1680

cgcaugcgcc ccggccucgg cuacaacgag gagcagaucc acaagcucga caaggucaac     1740

uucucccacc ucgccaagcg ccuccuccag gucuuccagg aggagugcgu ccagaaguac     1800

caggccuccc ucgucaccca cggcaagcgc augcgcgucg uccacgagac ccgcaaccac     1860

cuccgccucg ucggcugcuc cgucgccgcc ugcaacaccg aggcccaggg cguccaggag     1920

ucccucucca agcuccucga ggagcucucc caccagcucc uccaggaccg cgccaagggc     1980

gcccaggccu cccccccccc caucgccccc uaccccuccc ccacccgcaa ggaccuccuc     2040

cuccacaugc aggagcucug cgagggcaug aagcuccucg ccuccgaccu ccucgacaac     2100

aaccgcauca ucgagcgccu caaccgcguc cccgcccccc ccgacgucug a              2151


<210>  8651
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IKK__Homo_sapiens__AAF45307

<400>  8651
augcagagca ccgccaacua ccuguggcac acagacgauc uccuuggcca aggggcuacu       60

gcauccgugu auaaggccag aaauaaaaag ucuggagagc uggucgcggu uaaaguguuc      120

aacacgaccu cauacuugag gccccgggaa guacaggugc gcgaguuuga agucuuacga      180

aagcugaauc aucagaacau cgugaaacua uucgcuguug aggaaacagg uggcagucgu      240

cagaaggugc ucgucaugga guauugcagc uccgggucuc ugcuuucggu gcuggaguca      300

ccugaaaaug ccuuuggauu gccagaggac gaguuccucg uaguucugag augugugguc      360

gcaggcauga accaccugag ggaaaauggu auugugcauc gggauauaaa gccggggaac      420

aucaugcgcc ucgugggaga ggaaggccaa agcauuuaca aauuaacuga cuuuggcgcc      480

gcuagagagc uggaugacga ugaaaaguuc gucaguguuu augggaccga ggaauaccuu      540

caccccgaca uguaugagag ggcaguguug cggaaaccuc agcagaaggc cuuuggagua      600

acaguggauc ugugguccau cggugucacc cuauaccaug cugccacugg cucucuccca      660

uucauucccu uugggggacc ucgccgaaau aaagagauca uguacagaau aacaaccgaa      720

aagccagcgg gcgcaaucgc cggugcucag aggcgggaga acgggccccu ggaauggagc      780

uauacgcuuc cuauuacuug ccaacugucc uugggacucc agucacagcu ggugccaauc      840

uuagccaaua uucuggaggu ugaacaggca aaguguuggg gcuucgacca auuuuucgcu      900

gagaccagug auauccucca gcgugugguc gugcacguau uuagccuuuc ucaggccguu      960

cugcaccaua uauacauuca cgcgcauaac acaaucgcca uuuuccaaga ggcagugcac     1020

aaacagacuu ccgucgcucc gcgccaccag gaauauuugu ucgagggcca ucuaugcgug     1080

cuggaacccu cagucagcgc ccagcacauc gcucauacca cagccaguuc uccucucacc     1140

cuguuuucca cggcaauccc aaaggggcuu gccuucagag accccgcucu ggaugugccu     1200

aaauuuguuc caaaggugga cuugcaagcg gacuacaaua cugcaaaagg aguacucggu     1260

gccggcuauc aggcucugag guuagcccgg gcacugcuag augggcagga gcucauguuc     1320

cgaggacugc acugggucau ggaagugcuu caggccacau gucgcagaac cuuggagguu     1380

gcuaggacua gccugcucua ccugucgucu ucccuuggca cagagcgguu uucaagugug     1440

gccgguaccc ccgaaauuca agagcugaag gcagcggcug aauugcgcag cagacucagg     1500

acgcuggccg aggucuuauc ccguugcucu cagaacauaa ccgagacaca ggaaagccug     1560

ucaagucuaa aucgggagcu cgugaaaucc cgagaccagg uacaugaaga uagaagcauc     1620

caacagauuc aguguugccu ggacaagaug aacuucaucu auaagcaguu uaaaaagucu     1680

aggaugcgcc cggggcuugg cuacaacgag gaacaaauac acaaauugga uaaggugaau     1740

uucucacacc uggcaaaacg gcuccugcag guuuuucagg aggagugugu ccaaaaguac     1800

caggccaguu uagugacuca uggaaagaga augagggugg uccacgaaac ccgcaaccau     1860

cugcgacuug uuggcugcag cguggcugcc uguaauacag aggcacaggg ggugcaggaa     1920

uccuugucua aacuccugga ggaacuaucg caccaacugc uccaggaccg ggcuaaggga     1980

gcccaggcga gcccuccccc aauugccccu uaucccuccc caacucguaa agaucugcuu     2040

uugcacaugc aggagcugug cgaggguaug aaguuacucg cuucagaccu gcuugauaac     2100

aauagaauca ucgaaaggcu gaaccgcgua cccgcaccuc cagacgucug a              2151


<210>  8652
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IKK__Homo_sapiens__AAF45307

<400>  8652
augcagagca ccgccaacua ccuguggcac accgacgacc ugcugggcca gggcgccacc       60

gccagcgugu acaaggccag aaacaagaag agcggcgagc ugguggccgu gaagguguuc      120

aacaccacca gcuaccugag acccagagag gugcagguga gagaguucga ggugcugaga      180

aagcugaacc accagaacau cgugaagcug uucgccgugg aggagaccgg cggcagcaga      240

cagaaggugc uggugaugga guacugcagc agcggcagcc ugcugagcgu gcuggagagc      300

cccgagaacg ccuucggccu gcccgaggac gaguuccugg uggugcugag augcguggug      360

gccggcauga accaccugag agagaacggc aucgugcaca gagacaucaa gcccggcaac      420

aucaugagac uggugggcga ggagggccag agcaucuaca agcugaccga cuucggcgcc      480

gccagagagc uggacgacga cgagaaguuc gugagcgugu acggcaccga ggaguaccug      540

caccccgaca uguacgagag agccgugcug agaaagcccc agcagaaggc cuucggcgug      600

accguggacc uguggagcau cggcgugacc cuguaccacg ccgccaccgg cagccugccc      660

uucauccccu ucggcggccc cagaagaaac aaggagauca uguacagaau caccaccgag      720

aagcccgccg gcgccaucgc cggcgcccag agaagagaga acggcccccu ggaguggagc      780

uacacccugc ccaucaccug ccagcugagc cugggccugc agagccagcu ggugcccauc      840

cuggccaaca uccuggaggu ggagcaggcc aagugcuggg gcuucgacca guucuucgcc      900

gagaccagcg acauccugca gagaguggug gugcacgugu ucagccugag ccaggccgug      960

cugcaccaca ucuacaucca cgcccacaac accaucgcca ucuuccagga ggccgugcac     1020

aagcagacca gcguggcccc cagacaccag gaguaccugu ucgagggcca ccugugcgug     1080

cuggagccca gcgugagcgc ccagcacauc gcccacacca ccgccagcag cccccugacc     1140

cuguucagca ccgccauccc caagggccug gccuucagag accccgcccu ggacgugccc     1200

aaguucgugc ccaaggugga ccugcaggcc gacuacaaca ccgccaaggg cgugcugggc     1260

gccggcuacc aggcccugag acuggccaga gcccugcugg acggccagga gcugauguuc     1320

agaggccugc acugggugau ggaggugcug caggccaccu gcagaagaac ccuggaggug     1380

gccagaacca gccugcugua ccugagcagc agccugggca ccgagagauu cagcagcgug     1440

gccggcaccc ccgagaucca ggagcugaag gccgccgccg agcugagaag cagacugaga     1500

acccuggccg aggugcugag cagaugcagc cagaacauca ccgagaccca ggagagccug     1560

agcagccuga acagagagcu ggugaagagc agagaccagg ugcacgagga cagaagcauc     1620

cagcagaucc agugcugccu ggacaagaug aacuucaucu acaagcaguu caagaagagc     1680

agaaugagac ccggccuggg cuacaacgag gagcagaucc acaagcugga caaggugaac     1740

uucagccacc uggccaagag acugcugcag guguuccagg aggagugcgu gcagaaguac     1800

caggccagcc uggugaccca cggcaagaga augagagugg ugcacgagac cagaaaccac     1860

cugagacugg ugggcugcag cguggccgcc ugcaacaccg aggcccaggg cgugcaggag     1920

agccugagca agcugcugga ggagcugagc caccagcugc ugcaggacag agccaagggc     1980

gcccaggcca gccccccccc caucgccccc uaccccagcc ccaccagaaa ggaccugcug     2040

cugcacaugc aggagcugug cgagggcaug aagcugcugg ccagcgaccu gcuggacaac     2100

aacagaauca ucgagagacu gaacagagug cccgcccccc ccgacgugug a              2151


<210>  8653
<211>  2151
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IKK__Homo_sapiens__AAF45307

<400>  8653
augcagagca ccgccaacua ccuguggcac acagacgauc uccugggcca aggggcuacg       60

gccuccgugu auaaggcgag aaauaaaaag ucuggagagc uugucgcugu uaaaguguuc      120

aacaccacaa gcuaccugcg gccccgcgaa gugcagguca gagaguuuga agugcuccgg      180

aagcugaauc aucagaacau cguuaaacuu uucgccgugg aggaaaccgg cgggucccgc      240

cagaaggucc uggugaugga guauugcucu agcggauccc uccugucugu ucuggagagc      300

ccugaaaaug ccuuuggccu cccggaggac gaguuccugg ugguccuuag auguguggug      360

gcugggauga accaucugcg ggaaaaugga auuguccacc gcgauaucaa gcccggcaac      420

auuaugagac ucguuggcga ggaagggcaa uccaucuaca aacugacaga cuuuggagcc      480

gcucgggagc uugaugacga ugaaaaguuc gugagcgugu auggcaccga ggaauaccug      540

cacccugaca uguaugagcg cgccguccuc agaaaacccc agcagaaggc guuuggggug      600

acaguugauc uguggucuau uggagugacc cuguaccaug ccgcuacggg cucccucccu      660

uucauccccu uugggggacc ucggcgcaau aaagagauca uguacagaau uaccacagaa      720

aagccggccg gcgcuaucgc cggcgcgcag cggcgcgaga acgggccccu ggaauggagc      780

uauacccuuc cuauuacaug ccaacugucu cucggacugc agucccagcu uguccccauc      840

cuggccaaua uucucgaggu ggaacaggcu aaguguuggg gcuucgacca auuuuucgcc      900

gagaccagcg auauccugca gagaguugug guccacgugu uuucucuguc ccaggcuguc      960

cuccaccaua uuuacaucca cgcccauaac acgaucgcca uuuuccaaga ggcugugcac     1020

aaacagacaa gcguugcgcc ucggcaccag gaauaucugu ucgaggggca ucuuugcgug     1080

cuggaacccu ccgucucugc ccagcacauc gcucauacca cagccagcuc cccgcucacc     1140

cuguuuagca ccgccauucc uaagggacuu gcuuucagag accccgcccu ggaugugccu     1200

aaauuuguuc ccaaggugga ccuccaagcg gacuacaaua cagcuaaagg cguccugggg     1260

gccggauauc aggcccugcg ccucgcucgg gcccugcuug auggccagga gcugauguuc     1320

agaggccucc acugggugau ggaagugcug caggcuacgu gucgccggac ccuggagguu     1380

gccagaacau cucuucucua ccuguccagc ucucugggga ccgagcgcuu uagcuccguc     1440

gcgggaacac ccgaaaucca agagcucaag gccgcugccg aacugcgguc uagacuucgc     1500

acccuggcug aggugcucag ccggugcucc cagaacauua cggagacaca ggaaagccug     1560

ucuucccuga auagagagcu ugugaaaagc cgcgaccagg uccaugaaga ucggucuauc     1620

caacagaucc aguguugccu cgacaagaug aacuucauuu auaagcaguu uaaaaagucc     1680

agaaugcggc cuggccuggg guacaacgag gaacaaaucc acaaacugga uaaggugaau     1740

uucagccacc ucgccaaacg ccugcuucag guuuuucagg aggagugugu gcaaaaguac     1800

caggcguccc uggucaccca uggaaagaga augcgggugg uucacgaaac cagaaaccau     1860

cuccgccugg ugggcugcuc ugucgccgcu uguaauacag aggcccaggg ggugcaggaa     1920

agccugucca aacuucucga ggaacugucu caccaacugc uccaggaccg ggcuaagggc     1980

gcccaggcca gcccgccccc uauugcuccc uauccuuccc ccaccagaaa agaucugcuu     2040

cugcacaugc aggagcucug cgagggaaug aagcugcugg cgagcgaccu ucucgauaac     2100

aaucgcauca uugaaagacu gaaccggguu ccggccccuc ccgacgugug a              2151


<210>  8654
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__Q9Y6K9

<400>  8654

Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu Met Val Gln Pro 
1               5                   10                  15      


Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly Glu Glu Ser Pro 
            20                  25                  30          


Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu Gln Gly Ala Pro 
        35                  40                  45              


Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu Leu Arg Asp Ala 
    50                  55                  60                  


Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys Glu Glu Leu Leu 
65                  70                  75                  80  


His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe Leu Met Cys Lys 
                85                  90                  95      


Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly Leu Glu Lys Leu 
            100                 105                 110         


Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu Val Glu His Leu 
        115                 120                 125             


Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala Ser Val Lys Ala 
    130                 135                 140                 


Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser Gln Ser Arg Leu 
145                 150                 155                 160 


Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly Arg Ala Arg Ala 
                165                 170                 175     


Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg Glu Ala Leu Gln 
            180                 185                 190         


Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met Gln Gly Gln Ser 
        195                 200                 205             


Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala Ser Glu Glu Lys 
    210                 215                 220                 


Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln Leu Phe Gln Glu 
225                 230                 235                 240 


Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser Glu Arg Lys Arg 
                245                 250                 255     


Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln Gln Ala Glu Glu 
            260                 265                 270         


Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu Lys Glu Glu Ala 
        275                 280                 285             


Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val Leu Lys Ala Gln 
    290                 295                 300                 


Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg Gln Ala Arg Glu 
305                 310                 315                 320 


Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln Leu Glu Gln Leu 
                325                 330                 335     


Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln Glu Ser Ala Arg 
            340                 345                 350         


Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser Gln Ala Pro Leu 
        355                 360                 365             


Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala Leu Pro Ser Gln 
    370                 375                 380                 


Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys Cys Pro Lys Cys 
385                 390                 395                 400 


Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile His Val Met Glu 
                405                 410                 415     


Cys Ile Glu 
            


<210>  8655
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IKK__Homo_sapiens__AAC36330

<400>  8655
augaauaggc accucuggaa gagccaacug ugugagaugg ugcagcccag ugguggcccg       60

gcagcagauc aggacguacu gggcgaagag ucuccucugg ggaagccagc caugcugcac      120

cugccuucag aacagggcgc uccugagacc cuccagcgcu gccuggagga gaaucaagag      180

cuccgagaug ccauccggca gagcaaccag auucugcggg agcgcugcga ggagcuucug      240

cauuuccaag ccagccagag ggaggagaag gaguuccuca ugugcaaguu ccaggaggcc      300

aggaaacugg uggagagacu cggccuggag aagcucgauc ugaagaggca gaaggagcag      360

gcucugcggg agguggagca ccugaagaga ugccagcagc agauggcuga ggacaaggcc      420

ucugugaaag cccaggugac guccuugcuc ggggagcugc aggagagcca gagucgcuug      480

gaggcugcca cuaaggaaug ccaggcucug gagggucggg cccgggcggc cagcgagcag      540

gcgcggcagc uggagaguga gcgcgaggcg cugcagcagc agcacagcgu gcagguggac      600

cagcugcgca ugcagggcca gagcguggag gccgcgcucc gcauggagcg ccaggccgcc      660

ucggaggaga agaggaagcu ggcccaguug cagguggccu aucaccagcu cuuccaagaa      720

uacgacaacc acaucaagag cagcguggug ggcagugagc ggaagcgagg aaugcagcug      780

gaagaucuca aacagcagcu ccagcaggcc gaggaggccc ugguggccaa acaggaggug      840

aucgauaagc ugaaggagga ggccgagcag cacaagauug ugauggagac cguuccggug      900

cugaaggccc aggcggauau cuacaaggcg gacuuccagg cugagaggca ggcccgggag      960

aagcuggccg agaagaagga gcuccugcag gagcagcugg agcagcugca gagggaguac     1020

agcaaacuga aggccagcug ucaggagucg gccaggaucg aggacaugag gaagcggcau     1080

gucgaggucu cccaggcccc cuugcccccc gccccugccu accucuccuc uccccuggcc     1140

cugcccagcc agaggaggag cccccccgag gagccaccug acuucugcug ucccaagugc     1200

caguaucagg ccccugauau ggacacccug cagauacaug ucauggagug cauugaguag     1260


<210>  8656
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IKK__Homo_sapiens__AAC36330

<400>  8656
augaaccgcc accuguggaa gucccagcuc ugcgagaugg ugcagcccag cggcgggccg       60

gccgccgacc aggacguccu gggcgaggag agcccccugg ggaagcccgc gaugcuccac      120

cuccccuccg agcagggcgc cccggagacc cugcagcggu gccucgagga gaaccaggag      180

cugcgcgacg ccauccggca gagcaaccag auccugcgcg agcggugcga ggagcuccug      240

cacuuccagg ccucccagcg cgaggagaag gaguuccuga ugugcaaguu ccaggaggcc      300

cggaagcucg uggagcgccu ggggcuggag aagcucgacc ugaagcggca gaaggagcag      360

gcgcugcgcg agguggagca ccucaagcgg ugccagcagc agauggccga ggacaaggcc      420

agcgucaagg cccaggugac cucccugcug ggcgagcucc aggagagcca gucccgccug      480

gaggcggcca cgaaggagug ccaggcccug gagggccggg cccgcgccgc gagcgagcag      540

gcccggcagc ucgaguccga gcgcgaggcc cugcagcagc agcacagcgu gcaggucgac      600

cagcugcgga ugcaggggca guccguggag gccgcccucc gcauggagcg gcaggcggcc      660

agcgaggaga agcgcaagcu ggcccagcuc cagguggccu accaccagcu guuccaggag      720

uacgacaacc acaucaaguc cagcgucgug ggcuccgagc ggaagcgcgg gaugcagcug      780

gaggaccuga agcagcagcu gcagcaggcc gaggaggcgc ugguggccaa gcaggagguc      840

aucgacaagc ugaaggagga ggccgagcag cacaagaucg ugauggagac cgugcccguc      900

cucaaggccc aggccgacau cuacaaggcg gacuuccagg ccgagcgcca ggcccgggag      960

aagcuggccg agaagaagga gcugcuccag gagcagcugg agcagcugca gcgcgaguac     1020

agcaagcuca aggcguccug ccaggagagc gcccggaucg aggacaugcg caagcggcac     1080

guggagguga gccaggcgcc ccugcccccg gcccccgccu accuguccag cccccucgcc     1140

cugcccuccc agcgccggag cccgcccgag gagccgcccg acuucugcug ccccaagugc     1200

caguaccagg cccccgacau ggacacccug cagauccacg ucauggagug caucgaguga     1260


<210>  8657
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IKK__Homo_sapiens__AAC36330

<400>  8657
augaaccgcc accucuggaa gucccagcuc ugcgagaugg uccagcccuc cggcggcccc       60

gccgccgacc aggacguccu cggcgaggag uccccccucg gcaagcccgc caugcuccac      120

cuccccuccg agcagggcgc ccccgagacc cuccagcgcu gccucgagga gaaccaggag      180

cuccgcgacg ccauccgcca guccaaccag auccuccgcg agcgcugcga ggagcuccuc      240

cacuuccagg ccucccagcg cgaggagaag gaguuccuca ugugcaaguu ccaggaggcc      300

cgcaagcucg ucgagcgccu cggccucgag aagcucgacc ucaagcgcca gaaggagcag      360

gcccuccgcg aggucgagca ccucaagcgc ugccagcagc agauggccga ggacaaggcc      420

uccgucaagg cccaggucac cucccuccuc ggcgagcucc aggaguccca gucccgccuc      480

gaggccgcca ccaaggagug ccaggcccuc gagggccgcg cccgcgccgc cuccgagcag      540

gcccgccagc ucgaguccga gcgcgaggcc cuccagcagc agcacuccgu ccaggucgac      600

cagcuccgca ugcagggcca guccgucgag gccgcccucc gcauggagcg ccaggccgcc      660

uccgaggaga agcgcaagcu cgcccagcuc caggucgccu accaccagcu cuuccaggag      720

uacgacaacc acaucaaguc cuccgucguc ggcuccgagc gcaagcgcgg caugcagcuc      780

gaggaccuca agcagcagcu ccagcaggcc gaggaggccc ucgucgccaa gcaggagguc      840

aucgacaagc ucaaggagga ggccgagcag cacaagaucg ucauggagac cguccccguc      900

cucaaggccc aggccgacau cuacaaggcc gacuuccagg ccgagcgcca ggcccgcgag      960

aagcucgccg agaagaagga gcuccuccag gagcagcucg agcagcucca gcgcgaguac     1020

uccaagcuca aggccuccug ccaggagucc gcccgcaucg aggacaugcg caagcgccac     1080

gucgaggucu cccaggcccc ccuccccccc gcccccgccu accucuccuc cccccucgcc     1140

cuccccuccc agcgccgcuc cccccccgag gagccccccg acuucugcug ccccaagugc     1200

caguaccagg cccccgacau ggacacccuc cagauccacg ucauggagug caucgaguga     1260


<210>  8658
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IKK__Homo_sapiens__AAC36330

<400>  8658
augaacagac accuguggaa aagccagcuc ugcgagaugg ugcaacccuc cggcgggccu       60

gccgcugacc aggauguccu uggagaagag ucuccacugg guaaaccggc aauguugcau      120

uuacccucag aacagggcgc cccugagacc cugcagaggu gucuagaaga gaaucaagag      180

cuccgggacg cgauccgcca gaguaaccag auucugcgag aacguugcga ggaacuucug      240

cacuuccagg cuagccaaag agaggagaag gaauuuuuga uguguaaauu ccaggaggcc      300

aggaagcucg uugaacggcu ggggcuggag aaacucgauu uaaagcgcca gaaggaacag      360

gcacugagag agguggagca ucuuaaaagg ugccaacagc agauggccga agacaaggcu      420

uccguaaaag cacaagugac aucuuugcug ggagagcuac aggaaucgca gucacggcuc      480

gaggccgcua cuaaggaaug ucaggcccug gagggccgcg cgcgagcagc cagcgagcaa      540

gcuagacagc uugaaaguga gagggaagcc cugcagcagc aacacuccgu ccagguggau      600

caguugcgga ugcaggguca aucuguugag gcagcucucc guauggaacg ccaggccgcg      660

agcgaggaga aaagaaagcu ggcccaguua cagguggcau accaucaacu guuucaggaa      720

uaugacaauc acauaaaguc cucagucgug gggagugaga ggaaacgggg aaugcagcuc      780

gaagaucuua agcaacagcu gcagcaggcu gaggaggccu ugguagcuaa acaagaaguu      840

aucgacaagc uaaaagagga agccgagcag cacaagauug ugauggaaac ggucccagug      900

cugaaagcac aggccgauau cuacaaggcu gacuuccagg cggagcgaca agcacgcgag      960

aagcucgccg aaaagaagga gcugcuucag gaacagcugg agcaguugca aagagaauau     1020

agcaaacuca aggcuucuug ccaggagucc gccaggauug aggauaugcg gaaacgccau     1080

guggaagucu cacaggcacc ccugccucca gcccccgcuu acuuaagcag uccucuggcc     1140

cuaccaucuc aaagaagguc cccgcccgag gaaccuccag acuuuuguug ccccaagugu     1200

caguaucagg caccugauau ggacacccuc cagauccacg uuauggagug cauagaauga     1260


<210>  8659
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IKK__Homo_sapiens__AAC36330

<400>  8659
augaacagac accuguggaa gagccagcug ugcgagaugg ugcagcccag cggcggcccc       60

gccgccgacc aggacgugcu gggcgaggag agcccccugg gcaagcccgc caugcugcac      120

cugcccagcg agcagggcgc ccccgagacc cugcagagau gccuggagga gaaccaggag      180

cugagagacg ccaucagaca gagcaaccag auccugagag agagaugcga ggagcugcug      240

cacuuccagg ccagccagag agaggagaag gaguuccuga ugugcaaguu ccaggaggcc      300

agaaagcugg uggagagacu gggccuggag aagcuggacc ugaagagaca gaaggagcag      360

gcccugagag agguggagca ccugaagaga ugccagcagc agauggccga ggacaaggcc      420

agcgugaagg cccaggugac cagccugcug ggcgagcugc aggagagcca gagcagacug      480

gaggccgcca ccaaggagug ccaggcccug gagggcagag ccagagccgc cagcgagcag      540

gccagacagc uggagagcga gagagaggcc cugcagcagc agcacagcgu gcagguggac      600

cagcugagaa ugcagggcca gagcguggag gccgcccuga gaauggagag acaggccgcc      660

agcgaggaga agagaaagcu ggcccagcug cagguggccu accaccagcu guuccaggag      720

uacgacaacc acaucaagag cagcguggug ggcagcgaga gaaagagagg caugcagcug      780

gaggaccuga agcagcagcu gcagcaggcc gaggaggccc ugguggccaa gcaggaggug      840

aucgacaagc ugaaggagga ggccgagcag cacaagaucg ugauggagac cgugcccgug      900

cugaaggccc aggccgacau cuacaaggcc gacuuccagg ccgagagaca ggccagagag      960

aagcuggccg agaagaagga gcugcugcag gagcagcugg agcagcugca gagagaguac     1020

agcaagcuga aggccagcug ccaggagagc gccagaaucg aggacaugag aaagagacac     1080

guggagguga gccaggcccc ccugcccccc gcccccgccu accugagcag cccccuggcc     1140

cugcccagcc agagaagaag cccccccgag gagccccccg acuucugcug ccccaagugc     1200

caguaccagg cccccgacau ggacacccug cagauccacg ugauggagug caucgaguga     1260


<210>  8660
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IKK__Homo_sapiens__AAC36330

<400>  8660
augaacagac accuguggaa aagccagcuc ugcgagaugg ugcaacccuc cggcgggccu       60

gccgcugacc aggauguccu gggagaagag ucuccgcuug gcaaacccgc caugcugcau      120

cucccuagcg aacagggggc gcccgagacc cugcagcggu gucuugaaga gaaucaagag      180

cugcgcgacg cuaucagaca guccaaccag auucuccggg aacgcugcga ggaacugcug      240

cacuuccagg ccucucaaag agaggagaag gaauuucuca uguguaaauu ccaggaggcc      300

cggaagcugg uugaacgccu uggacuggag aaacucgauc ugaagagaca gaaggaacag      360

gcccuucggg agguggagca ucugaaacgc ugccaacagc agauggccga agacaaggcu      420

agcgugaaag cccaagucac aucccuccug ggcgagcugc aggaaucuca gagcagacuc      480

gaggcggcca cgaaggaaug ucaggcucug gaggggcggg cccgcgcugc cuccgagcaa      540

gcgagacagc uugaaagcga gcgggaagcc cugcagcagc aacacucugu gcagguugau      600

cagcuccgca ugcagggaca auccguggag gcugcccuga gaauggaacg gcaggcugcc      660

agcgaggaga aaagaaaacu ugcccagcug caggucgcuu accaucaacu cuuucaggaa      720

uaugacaauc acaucaaguc uuccgugguu ggcagcgagc gcaagcgggg caugcagcug      780

gaagaucuga agcaacagcu ccagcaggcg gaggaggccc ugguggcuaa acaagaaguc      840

auugacaaac uuaaggagga agccgagcag cacaagaucg ugauggaaac cgugccuguc      900

cugaaagccc aggcugauau uuacaaggcc gacuuccagg cggagagaca agcucgcgag      960

aagcucgccg aaaagaagga gcugcuucag gaacagcugg agcagcucca acgggaauau     1020

ucuaaacuga aggccuccug ccaggagagc gcuagaaucg aggauaugcg caaacggcau     1080

guugaagugu cccaggcucc ccugccuccg gcucccgccu accucucuag cccucuggcg     1140

cuucccuccc aaagacgcag cccucccgag gaaccgccug acuuuuguug ccccaagugu     1200

caguaucagg ccccugauau ggacacacug cagauccacg ugauggagug cauugaauga     1260


<210>  8661
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__O43353

<400>  8661

Met Asn Gly Glu Ala Ile Cys Ser Ala Leu Pro Thr Ile Pro Tyr His 
1               5                   10                  15      


Lys Leu Ala Asp Leu Arg Tyr Leu Ser Arg Gly Ala Ser Gly Thr Val 
            20                  25                  30          


Ser Ser Ala Arg His Ala Asp Trp Arg Val Gln Val Ala Val Lys His 
        35                  40                  45              


Leu His Ile His Thr Pro Leu Leu Asp Ser Glu Arg Lys Asp Val Leu 
    50                  55                  60                  


Arg Glu Ala Glu Ile Leu His Lys Ala Arg Phe Ser Tyr Ile Leu Pro 
65                  70                  75                  80  


Ile Leu Gly Ile Cys Asn Glu Pro Glu Phe Leu Gly Ile Val Thr Glu 
                85                  90                  95      


Tyr Met Pro Asn Gly Ser Leu Asn Glu Leu Leu His Arg Lys Thr Glu 
            100                 105                 110         


Tyr Pro Asp Val Ala Trp Pro Leu Arg Phe Arg Ile Leu His Glu Ile 
        115                 120                 125             


Ala Leu Gly Val Asn Tyr Leu His Asn Met Thr Pro Pro Leu Leu His 
    130                 135                 140                 


His Asp Leu Lys Thr Gln Asn Ile Leu Leu Asp Asn Glu Phe His Val 
145                 150                 155                 160 


Lys Ile Ala Asp Phe Gly Leu Ser Lys Trp Arg Met Met Ser Leu Ser 
                165                 170                 175     


Gln Ser Arg Ser Ser Lys Ser Ala Pro Glu Gly Gly Thr Ile Ile Tyr 
            180                 185                 190         


Met Pro Pro Glu Asn Tyr Glu Pro Gly Gln Lys Ser Arg Ala Ser Ile 
        195                 200                 205             


Lys His Asp Ile Tyr Ser Tyr Ala Val Ile Thr Trp Glu Val Leu Ser 
    210                 215                 220                 


Arg Lys Gln Pro Phe Glu Asp Val Thr Asn Pro Leu Gln Ile Met Tyr 
225                 230                 235                 240 


Ser Val Ser Gln Gly His Arg Pro Val Ile Asn Glu Glu Ser Leu Pro 
                245                 250                 255     


Tyr Asp Ile Pro His Arg Ala Arg Met Ile Ser Leu Ile Glu Ser Gly 
            260                 265                 270         


Trp Ala Gln Asn Pro Asp Glu Arg Pro Ser Phe Leu Lys Cys Leu Ile 
        275                 280                 285             


Glu Leu Glu Pro Val Leu Arg Thr Phe Glu Glu Ile Thr Phe Leu Glu 
    290                 295                 300                 


Ala Val Ile Gln Leu Lys Lys Thr Lys Leu Gln Ser Val Ser Ser Ala 
305                 310                 315                 320 


Ile His Leu Cys Asp Lys Lys Lys Met Glu Leu Ser Leu Asn Ile Pro 
                325                 330                 335     


Val Asn His Gly Pro Gln Glu Glu Ser Cys Gly Ser Ser Gln Leu His 
            340                 345                 350         


Glu Asn Ser Gly Ser Pro Glu Thr Ser Arg Ser Leu Pro Ala Pro Gln 
        355                 360                 365             


Asp Asn Asp Phe Leu Ser Arg Lys Ala Gln Asp Cys Tyr Phe Met Lys 
    370                 375                 380                 


Leu His His Cys Pro Gly Asn His Ser Trp Asp Ser Thr Ile Ser Gly 
385                 390                 395                 400 


Ser Gln Arg Ala Ala Phe Cys Asp His Lys Thr Thr Pro Cys Ser Ser 
                405                 410                 415     


Ala Ile Ile Asn Pro Leu Ser Thr Ala Gly Asn Ser Glu Arg Leu Gln 
            420                 425                 430         


Pro Gly Ile Ala Gln Gln Trp Ile Gln Ser Lys Arg Glu Asp Ile Val 
        435                 440                 445             


Asn Gln Met Thr Glu Ala Cys Leu Asn Gln Ser Leu Asp Ala Leu Leu 
    450                 455                 460                 


Ser Arg Asp Leu Ile Met Lys Glu Asp Tyr Glu Leu Val Ser Thr Lys 
465                 470                 475                 480 


Pro Thr Arg Thr Ser Lys Val Arg Gln Leu Leu Asp Thr Thr Asp Ile 
                485                 490                 495     


Gln Gly Glu Glu Phe Ala Lys Val Ile Val Gln Lys Leu Lys Asp Asn 
            500                 505                 510         


Lys Gln Met Gly Leu Gln Pro Tyr Pro Glu Ile Leu Val Val Ser Arg 
        515                 520                 525             


Ser Pro Ser Leu Asn Leu Leu Gln Asn Lys Ser Met 
    530                 535                 540 


<210>  8662
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__AAC24561

<400>  8662
augaacgggg aggccaucug cagcgcccug cccaccauuc ccuaccacaa acucgccgac       60

cugcgcuacc ugagccgcgg cgccucuggc acugugucgu ccgcccgcca cgcagacugg      120

cgcguccagg uggccgugaa gcaccugcac auccacacuc cgcugcucga cagugaaaga      180

aaggaugucu uaagagaagc ugaaauuuua cacaaagcua gauuuaguua cauucuucca      240

auuuugggaa uuugcaauga gccugaauuu uugggaauag uuacugaaua caugccaaau      300

ggaucauuaa augaacuccu acauaggaaa acugaauauc cugauguugc uuggccauug      360

agauuucgca uccugcauga aauugcccuu gguguaaauu accugcacaa uaugacuccu      420

ccuuuacuuc aucaugacuu gaagacucag aauaucuuau uggacaauga auuucauguu      480

aagauugcag auuuugguuu aucaaagugg cgcaugaugu cccucucaca gucacgaagu      540

agcaaaucug caccagaagg agggacaauu aucuauaugc caccugaaaa cuaugaaccu      600

ggacaaaaau caagggccag uaucaagcac gauauauaua gcuaugcagu uaucacaugg      660

gaaguguuau ccagaaaaca gccuuuugaa gaugucacca auccuuugca gauaauguau      720

agugugucac aaggacaucg accuguuauu aaugaagaaa guuugccaua ugauauaccu      780

caccgagcac guaugaucuc ucuaauagaa aguggauggg cacaaaaucc agaugaaaga      840

ccaucuuucu uaaaauguuu aauagaacuu gaaccaguuu ugagaacauu ugaagagaua      900

acuuuucuug aagcuguuau ucagcuaaag aaaacaaagu uacagagugu uucaagugcc      960

auucaccuau gugacaagaa gaaaauggaa uuaucucuga acauaccugu aaaucauggu     1020

ccacaagagg aaucaugugg auccucucag cuccaugaaa auagugguuc uccugaaacu     1080

ucaagguccc ugccagcucc ucaagacaau gauuuuuuau cuagaaaagc ucaagacugu     1140

uauuuuauga agcugcauca cuguccugga aaucacaguu gggauagcac cauuucugga     1200

ucucaaaggg cugcauucug ugaucacaag accacuccau gcucuucagc aauaauaaau     1260

ccacucucaa cugcaggaaa cucagaacgu cugcagccug guauagccca gcaguggauc     1320

cagagcaaaa gggaagacau ugugaaccaa augacagaag ccugccuuaa ccagucgcua     1380

gaugcccuuc uguccaggga cuugaucaug aaagaggacu augaacuugu uaguaccaag     1440

ccuacaagga ccucaaaagu cagacaauua cuagacacua cugacaucca aggagaagaa     1500

uuugccaaag uuauaguaca aaaauugaaa gauaacaaac aaaugggucu ucagccuuac     1560

ccggaaauac uugugguuuc uagaucacca ucuuuaaauu uacuucaaaa uaaaagcaug     1620

uaa                                                                   1623


<210>  8663
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__AAC24561

<400>  8663
augaacggcg aggccaucug cagcgcccug cccaccaucc cguaccacaa gcucgcggac       60

cugcgcuacc ugucccgcgg ggccagcggc accgugucca gcgcccggca cgccgacugg      120

cggguccagg uggccgugaa gcaccuccac auccacacgc cccugcugga cuccgagcgc      180

aaggacgucc uccgggaggc ggagauccug cacaaggccc gcuucagcua cauccugccc      240

auccucggga ucugcaacga gcccgaguuc cugggcaucg ugaccgagua caugccgaac      300

gggucccuga acgagcuccu gcaccggaag accgaguacc ccgacguggc cuggccccug      360

cgcuuccgga uccuccacga gaucgcccug ggcgucaacu accugcacaa caugacgccc      420

ccgcuccugc accacgaccu gaagacccag aacauccucc uggacaacga guuccacgug      480

aagaucgcgg acuucggccu gagcaagugg cgcaugaugu cccucagcca gucccggagc      540

uccaagagcg cccccgaggg cgggaccauc aucuacaugc cgcccgagaa cuacgagccc      600

gggcagaagu cccgcgccag caucaagcac gacaucuacu ccuacgccgu gaucaccugg      660

gagguccuga gccggaagca gcccuucgag gacgugacca acccccugca gaucauguac      720

uccgugagcc agggccaccg ccccgucauc aacgaggaga gccucccgua cgacaucccc      780

caccgggccc gcaugaucuc ccugaucgag agcggguggg cgcagaaccc cgacgagcgg      840

cccuccuucc ugaagugccu caucgagcug gagccggugc ugcgcacguu cgaggagauc      900

accuuccucg aggccgugau ccagcugaag aagaccaagc ugcagagcgu cuccagcgcc      960

auccaccucu gcgacaagaa gaagauggag cugucccuga acauccccgu gaaccacggc     1020

ccccaggagg agagcugcgg cuccagccag cuccacgaga acuccgggag ccccgagacc     1080

ucccggagcc ugccggcgcc ccaggacaac gacuuccugu cccgcaaggc ccaggacugc     1140

uacuucauga agcuccacca cugccccggc aaccacagcu gggacuccac gaucagcggg     1200

ucccagcggg ccgccuucug cgaccacaag accacccccu gcagcagcgc caucaucaac     1260

ccgcugucca ccgccggcaa cagcgagcgc cugcagcccg gcaucgccca gcaguggauc     1320

caguccaagc gcgaggacau cgugaaccag augacggagg cgugccucaa ccagagccug     1380

gacgcccugc ucucccggga ccugaucaug aaggaggacu acgagcuggu cagcaccaag     1440

cccacccgca ccuccaaggu gcggcagcug cucgacacga ccgacaucca gggggaggag     1500

uucgccaagg ugaucgucca gaagcugaag gacaacaagc agaugggccu gcagccguac     1560

cccgagaucc ucguggugag ccgcuccccc agccugaacc ugcuccagaa caaguccaug     1620

uga                                                                   1623


<210>  8664
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__AAC24561

<400>  8664
augaacggcg aggccaucug cuccgcccuc cccaccaucc ccuaccacaa gcucgccgac       60

cuccgcuacc ucucccgcgg cgccuccggc accgucuccu ccgcccgcca cgccgacugg      120

cgcguccagg ucgccgucaa gcaccuccac auccacaccc cccuccucga cuccgagcgc      180

aaggacgucc uccgcgaggc cgagauccuc cacaaggccc gcuucuccua cauccucccc      240

auccucggca ucugcaacga gcccgaguuc cucggcaucg ucaccgagua caugcccaac      300

ggcucccuca acgagcuccu ccaccgcaag accgaguacc ccgacgucgc cuggccccuc      360

cgcuuccgca uccuccacga gaucgcccuc ggcgucaacu accuccacaa caugaccccc      420

ccccuccucc accacgaccu caagacccag aacauccucc ucgacaacga guuccacguc      480

aagaucgccg acuucggccu cuccaagugg cgcaugaugu cccucuccca gucccgcucc      540

uccaaguccg cccccgaggg cggcaccauc aucuacaugc cccccgagaa cuacgagccc      600

ggccagaagu cccgcgccuc caucaagcac gacaucuacu ccuacgccgu caucaccugg      660

gagguccucu cccgcaagca gcccuucgag gacgucacca acccccucca gaucauguac      720

uccgucuccc agggccaccg ccccgucauc aacgaggagu cccuccccua cgacaucccc      780

caccgcgccc gcaugaucuc ccucaucgag uccggcuggg cccagaaccc cgacgagcgc      840

cccuccuucc ucaagugccu caucgagcuc gagcccgucc uccgcaccuu cgaggagauc      900

accuuccucg aggccgucau ccagcucaag aagaccaagc uccaguccgu cuccuccgcc      960

auccaccucu gcgacaagaa gaagauggag cucucccuca acauccccgu caaccacggc     1020

ccccaggagg aguccugcgg cuccucccag cuccacgaga acuccggcuc ccccgagacc     1080

ucccgcuccc uccccgcccc ccaggacaac gacuuccucu cccgcaaggc ccaggacugc     1140

uacuucauga agcuccacca cugccccggc aaccacuccu gggacuccac caucuccggc     1200

ucccagcgcg ccgccuucug cgaccacaag accacccccu gcuccuccgc caucaucaac     1260

ccccucucca ccgccggcaa cuccgagcgc cuccagcccg gcaucgccca gcaguggauc     1320

caguccaagc gcgaggacau cgucaaccag augaccgagg ccugccucaa ccagucccuc     1380

gacgcccucc ucucccgcga ccucaucaug aaggaggacu acgagcucgu cuccaccaag     1440

cccacccgca ccuccaaggu ccgccagcuc cucgacacca ccgacaucca gggcgaggag     1500

uucgccaagg ucaucgucca gaagcucaag gacaacaagc agaugggccu ccagcccuac     1560

cccgagaucc ucgucgucuc ccgcuccccc ucccucaacc uccuccagaa caaguccaug     1620

uga                                                                   1623


<210>  8665
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__AAC24561

<400>  8665
augaacggcg aggccaucug cagcgcucug ccaaccauuc cuuaccacaa gcucgcagac       60

cuuagauauc uguccagggg agccucuggg acagugucaa gugcgcggca ugcugauugg      120

cgcguccagg uugccgugaa acacuugcau auacacacuc cauuacugga cagcgaacga      180

aaggauguac uacgugaggc agaaauccuc cauaaagcca gauucuccua cauucugccg      240

auccuuggua uuuguaauga gcccgaauuu cugggcaucg ugacggagua uaugccuaac      300

gggucuuuga augagcuccu gcacaggaag accgaauacc cagacgucgc uuggccccug      360

cgguuccgca uacuccacga gaucgcauua ggagugaacu aucugcauaa uaugacaccu      420

ccacuuuugc accaugaucu gaaaacucaa aacauucuac ucgacaauga auuucacguu      480

aagaucgccg auuucggccu gucgaagugg agaaugaugu cacuuagcca gaguaggucc      540

ucuaaaagcg cucccgaggg ugggaccauu aucuacaugc cuccagagaa cuaugaaccg      600

ggacagaagu cccgggccuc aauaaaacac gacauuuaca guuacgcggu gaucacaugg      660

gagguccuga gccgcaagca gcccuuugaa gaugugacca auccuuugca aauuauguau      720

ucuguauccc agggccaucg accaguuauc aacgaggaau cacuccccua cgacaucccu      780

cacagagcaa ggaugauuag ccugauagag aguggcuggg cccagaaucc agaugagcgg      840

cccucuuucu uaaaaugccu gaucgaacuc gagccggugc uucguacuuu ugaagagauu      900

acauuccugg aagcugucau ccaguugaag aagaccaaac uacaauccgu gagcucggcc      960

auacaucugu gugacaagaa aaagauggag cucucucuga acauuccugu gaaucacggg     1020

ccccaggagg aauccugcgg aucaagucag cuucaugaga acagcgguuc cccagaaacg     1080

ucucgcagcc ugccugcacc ccaggauaau gacuuuuugu caagaaaagc ucaagacugu     1140

uauuucauga agcuccacca cugcccaggc aaccauaguu gggauuccac uaucagcggg     1200

ucucagaggg ccgcguuuug ugaccacaaa accacacccu gcucaagugc caucauuaac     1260

ccucugagca cugcaggaaa uuccgagcgg uuacagccag gcaucgcuca acaguggauu     1320

cagucuaagc gagaagauau agucaaccag augaccgagg ccugucugaa ucaaucgcua     1380

gacgcucucc ugagccgcga ucuuaucaug aaggaggacu acgaauuggu uuccacaaaa     1440

ccgaccagaa cgucaaaggu gaggcagcug cucgauacua cagacauuca gggugaggag     1500

uucgccaaag uaaucgugca gaagcugaaa gauaacaagc aaauggggcu ucagcccuau     1560

ccugaaaucc uggucgugag ucggucuccc agcuugaauc uccugcagaa caaguccaug     1620

uga                                                                   1623


<210>  8666
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__AAC24561

<400>  8666
augaacggcg aggccaucug cagcgcccug cccaccaucc ccuaccacaa gcuggccgac       60

cugagauacc ugagcagagg cgccagcggc accgugagca gcgccagaca cgccgacugg      120

agagugcagg uggccgugaa gcaccugcac auccacaccc cccugcugga cagcgagaga      180

aaggacgugc ugagagaggc cgagauccug cacaaggcca gauucagcua cauccugccc      240

auccugggca ucugcaacga gcccgaguuc cugggcaucg ugaccgagua caugcccaac      300

ggcagccuga acgagcugcu gcacagaaag accgaguacc ccgacguggc cuggccccug      360

agauucagaa uccugcacga gaucgcccug ggcgugaacu accugcacaa caugaccccc      420

ccccugcugc accacgaccu gaagacccag aacauccugc uggacaacga guuccacgug      480

aagaucgccg acuucggccu gagcaagugg agaaugauga gccugagcca gagcagaagc      540

agcaagagcg cccccgaggg cggcaccauc aucuacaugc cccccgagaa cuacgagccc      600

ggccagaaga gcagagccag caucaagcac gacaucuaca gcuacgccgu gaucaccugg      660

gaggugcuga gcagaaagca gcccuucgag gacgugacca acccccugca gaucauguac      720

agcgugagcc agggccacag acccgugauc aacgaggaga gccugcccua cgacaucccc      780

cacagagcca gaaugaucag ccugaucgag agcggcuggg cccagaaccc cgacgagaga      840

cccagcuucc ugaagugccu gaucgagcug gagcccgugc ugagaaccuu cgaggagauc      900

accuuccugg aggccgugau ccagcugaag aagaccaagc ugcagagcgu gagcagcgcc      960

auccaccugu gcgacaagaa gaagauggag cugagccuga acauccccgu gaaccacggc     1020

ccccaggagg agagcugcgg cagcagccag cugcacgaga acagcggcag ccccgagacc     1080

agcagaagcc ugcccgcccc ccaggacaac gacuuccuga gcagaaaggc ccaggacugc     1140

uacuucauga agcugcacca cugccccggc aaccacagcu gggacagcac caucagcggc     1200

agccagagag ccgccuucug cgaccacaag accacccccu gcagcagcgc caucaucaac     1260

ccccugagca ccgccggcaa cagcgagaga cugcagcccg gcaucgccca gcaguggauc     1320

cagagcaaga gagaggacau cgugaaccag augaccgagg ccugccugaa ccagagccug     1380

gacgcccugc ugagcagaga ccugaucaug aaggaggacu acgagcuggu gagcaccaag     1440

cccaccagaa ccagcaaggu gagacagcug cuggacacca ccgacaucca gggcgaggag     1500

uucgccaagg ugaucgugca gaagcugaag gacaacaagc agaugggccu gcagcccuac     1560

cccgagaucc ugguggugag cagaagcccc agccugaacc ugcugcagaa caagagcaug     1620

uga                                                                   1623


<210>  8667
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__AAC24561

<400>  8667
augaacggcg aggccaucug cagcgcucug cccaccauuc cuuaccacaa gcucgccgac       60

cugagauauc uuuccagagg ggcgucugga acagugagcu ccgcucgcca ugccgauugg      120

agaguccagg uugccgugaa acaucugcac auccacacgc cgcuccugga cucugaacgg      180

aaggaugugc uucgcgaggc ugaaauucug cauaaagcca gauucagcua cauccucccc      240

auucugggca ucuguaauga gccugaauuu cuggggaucg ucaccgagua uaugcccaac      300

ggaucccuca augagcugcu ucaccggaag acagaauacc cugacguggc uuggccccug      360

cgcuuccgga uucuccacga gaucgcccug ggcguuaacu aucuucauaa uaugaccccu      420

ccgcugcucc accaugaucu gaaaacacaa aacauucugc ucgacaauga auuucacgug      480

aagaucgcgg auuucgggcu gucuaagugg cggaugauga gccuuuccca gagcagaucu      540

uccaaaagcg cccccgaggg aggcaccauu aucuacaugc cucccgagaa cuaugaaccu      600

ggccagaagu cucgcgcuuc cauuaaacac gacaucuaca gcuacgccgu caucacaugg      660

gaggugcugu cucggaagca gcccuuugaa gauguuacca auccgcucca aauuauguau      720

uccgugagcc aggggcaucg cccugucauc aacgaggaau cccugcccua cgacauuccu      780

cacagagcuc ggaugaucuc ucuuauugag agcggauggg cccagaaucc cgaugagcgc      840

cccuccuucc ugaaaugccu caucgaacug gagccugugc ugagaacguu ugaagagauc      900

accuuccucg aagcggugau ucagcugaag aagacaaaac uucaaagcgu cucuuccgcc      960

auccaucugu gugacaagaa aaagauggag cucagccuga acauuccggu uaaucacggc     1020

ccccaggagg aaucuugcgg gagcucccag cuucaugaga acucuggaag cccugaaacc     1080

ucccggagcc ugcccgcucc ucaggauaau gacuuucucu cuagaaaagc ccaagacugu     1140

uauuucauga agcugcacca cugccccggc aaccauuccu gggauagcac aaucucuggg     1200

ucccagcgcg cugccuuuug ugaccacaaa accacgccgu gcagcuccgc cauuaucaac     1260

ccucugucua cagcuggaaa uagcgagcgg cuccagcccg gcaucgcgca acaguggauu     1320

caguccaaga gagaagauau cgugaaccag augaccgagg ccugucugaa ucaaucucuu     1380

gacgcucugc ucagccgcga ucugauuaug aaggaggacu acgaacuggu guccacaaaa     1440

ccuacccgga ccagcaaggu cagacagcuu cucgauacaa cggacaucca gggcgaggag     1500

uucgccaaag ugauuguuca gaagcugaaa gauaacaagc aaauggggcu gcagcccuau     1560

ccugaaaucc ucguggucuc ucgcuccccc agccugaauc uucugcagaa caagucuaug     1620

uga                                                                   1623


<210>  8668
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__Q8N9C1

<400>  8668

Met Ile Val Val Leu Ser Pro Asp Tyr Val Thr Glu Lys Ser Ile Ser 
1               5                   10                  15      


Met Leu Glu Phe Lys Leu Gly Val Met Cys Gln Asn Ser Ile Ala Thr 
            20                  25                  30          


Lys Leu Ile Val Val Glu Tyr Arg Pro Leu Glu His Pro His Pro Gly 
        35                  40                  45              


Ile Leu Gln Leu Lys Glu Ser Val Ser Phe Val Ser Trp Lys Gly Glu 
    50                  55                  60                  


Lys Ser Lys His Ser Gly Ser Lys Phe Trp Lys Ala Leu Arg Leu Ala 
65                  70                  75                  80  


Leu Pro Leu Arg Ser Leu Ser Ala Ser Ser Gly Trp Asn Glu Ser Cys 
                85                  90                  95      


Ser Ser Gln Ser Asp Ile Ser Leu Asp His Val Gln Arg Arg Arg Ser 
            100                 105                 110         


Arg Leu Lys Glu Pro Pro Glu Leu Gln Ser Ser Glu Arg Ala Ala Gly 
        115                 120                 125             


Ser Pro Pro Ala Pro Gly Thr Met Ser Lys His Arg Gly Lys Ser Ser 
    130                 135                 140                 


Ala Thr Cys Arg Cys Cys Val Thr Tyr Cys Glu Gly Glu Asn His Leu 
145                 150                 155                 160 


Arg Asn Lys Ser Arg Ala Glu Ile His Asn Gln Pro Gln Trp Glu Thr 
                165                 170                 175     


His Leu Cys Lys Pro Val Pro Gln Glu Ser Glu Thr Gln Trp Ile Gln 
            180                 185                 190         


Asn Gly Thr Arg Leu Glu Pro Pro Ala Pro Gln Ile Ser Ala Leu Ala 
        195                 200                 205             


Leu His His Phe Thr Asp Leu Ser Asn Asn Asn Asp Phe Tyr Ile Leu 
    210                 215                 220                 






<210>  8669
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__BAC04487

<400>  8669
augauuguug uucugagccc ugacuaugug acagaaaaga gcaucagcau gcuggaguuu       60

aaacugggug ucaugugcca gaacuccauu gccaccaagc ucauuguggu ugaguaccgu      120

ccccuugagc acccucaccc aggcauucuu cagcucaaag agucuguguc uuuugugagc      180

uggaagggag aaaaguccaa acauucuggc ucuaaauucu ggaaagcuuu gcgguuggcu      240

cuuccccuga gaagucugag ugccaguucu ggcuggaaug agagcugcuc uucccagucu      300

gacaucaguc uggaucacgu ucaaaggagg agaagucguu ugaaagagcc cccagaacuu      360

cagagcucag agagggcugc agguagcccu ccagccccag gcacaauguc caagcaccga      420

gggaaguccu ccgccaccug ccgcuguugu gucaccuacu gugaaggaga gaaucaccuu      480

aggaacaaga gccgggcaga gauucauaac cagccccagu gggagacaca ccucuguaag      540

ccuguucccc aagagucaga aacucaaugg auacaaaaug gcaccagauu ggaacccccu      600

gcuccccaga ucucagcccu ugcucuucau cauuucacgg acuuauccaa uaacaacgac      660

uuuuauaucc uauaa                                                       675


<210>  8670
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__BAC04487

<400>  8670
augaucgugg uccugagccc cgacuacgug accgagaagu ccaucagcau gcucgaguuc       60

aagcugggcg ugaugugcca gaacuccauc gccaccaagc ugaucgucgu ggaguaccgc      120

ccgcucgagc acccccaccc cgggauccug cagcugaagg agagcguguc cuucgucagc      180

uggaagggcg agaaguccaa gcacagcggg uccaaguucu ggaaggcccu ccggcuggcg      240

cugccccucc gcagccuguc cgccagcucc ggcuggaacg agagcugcuc cagccagucc      300

gacaucagcc uggaccacgu gcagcggcgc cggucccgcc ucaaggagcc gcccgagcug      360

cagagcagcg agcgggccgc cggguccccg cccgcccccg gcacgaugag caagcaccgc      420

ggcaagucca gcgcgaccug ccggugcugc gugaccuacu gcgaggggga gaaccaccuc      480

cgcaacaagu cccgggccga gauccacaac cagccccagu gggagaccca ccugugcaag      540

cccguccccc aggagagcga gacgcagugg auccagaacg gcacccgccu ggagccgccc      600

gcgccccaga ucuccgcccu ggcccuccac cacuucaccg accugagcaa caacaacgac      660

uucuacaucc uguga                                                       675


<210>  8671
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__BAC04487

<400>  8671
augaucgucg uccucucccc cgacuacguc accgagaagu ccaucuccau gcucgaguuc       60

aagcucggcg ucaugugcca gaacuccauc gccaccaagc ucaucgucgu cgaguaccgc      120

ccccucgagc acccccaccc cggcauccuc cagcucaagg aguccgucuc cuucgucucc      180

uggaagggcg agaaguccaa gcacuccggc uccaaguucu ggaaggcccu ccgccucgcc      240

cucccccucc gcucccucuc cgccuccucc ggcuggaacg aguccugcuc cucccagucc      300

gacaucuccc ucgaccacgu ccagcgccgc cgcucccgcc ucaaggagcc ccccgagcuc      360

caguccuccg agcgcgccgc cggcuccccc cccgcccccg gcaccauguc caagcaccgc      420

ggcaaguccu ccgccaccug ccgcugcugc gucaccuacu gcgagggcga gaaccaccuc      480

cgcaacaagu cccgcgccga gauccacaac cagccccagu gggagaccca ccucugcaag      540

cccguccccc aggaguccga gacccagugg auccagaacg gcacccgccu cgagcccccc      600

gccccccaga ucuccgcccu cgcccuccac cacuucaccg accucuccaa caacaacgac      660

uucuacaucc ucuga                                                       675


<210>  8672
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__BAC04487

<400>  8672
augaucgugg uccugagccc cgacuacguu accgagaagu ccauuucuau gcucgaguuc       60

aaacuuggcg ugaugugcca gaacucaaua gccacaaagc ugaucguagu ggaauauaga      120

ccuuuggaac acccacaucc ggggauuuua caacugaaag agagugucag cuuugugucc      180

uggaagggag aaaaaucuaa gcacucgggu ucaaaguucu ggaaagcucu aaggcucgca      240

cugccccuuc ggagccugag ugccuccucu ggcuggaaug agagcuguuc cucacagagu      300

gauaucagcu uggaccaugu ucagcgccga cguucuagac ucaaggagcc uccagaacug      360

caguccucag agagggcggc ugggaguccc ccugccccag gaacuaugag caaacaccgg      420

ggcaagucuu ccgcaacgug ccgcuguugc gugaccuacu gugaagguga gaaccaucug      480

agaaauaaaa gcagggccga gauucacaac caaccccagu gggaaacaca ccucugcaag      540

ccugucccac aggagucgga aacucagugg auccaaaaug ggacccgguu agagccgccc      600

gcuccucaga uaucugcacu ggcccuucau cacuuuacag auuuguccaa caauaacgac      660

uucuauaucc uguga                                                       675


<210>  8673
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__BAC04487

<400>  8673
augaucgugg ugcugagccc cgacuacgug accgagaaga gcaucagcau gcuggaguuc       60

aagcugggcg ugaugugcca gaacagcauc gccaccaagc ugaucguggu ggaguacaga      120

ccccuggagc acccccaccc cggcauccug cagcugaagg agagcgugag cuucgugagc      180

uggaagggcg agaagagcaa gcacagcggc agcaaguucu ggaaggcccu gagacuggcc      240

cugccccuga gaagccugag cgccagcagc ggcuggaacg agagcugcag cagccagagc      300

gacaucagcc uggaccacgu gcagagaaga agaagcagac ugaaggagcc ccccgagcug      360

cagagcagcg agagagccgc cggcagcccc cccgcccccg gcaccaugag caagcacaga      420

ggcaagagca gcgccaccug cagaugcugc gugaccuacu gcgagggcga gaaccaccug      480

agaaacaaga gcagagccga gauccacaac cagccccagu gggagaccca ccugugcaag      540

cccgugcccc aggagagcga gacccagugg auccagaacg gcaccagacu ggagcccccc      600

gccccccaga ucagcgcccu ggcccugcac cacuucaccg accugagcaa caacaacgac      660

uucuacaucc uguga                                                       675


<210>  8674
<211>  675
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__BAC04487

<400>  8674
augaucgugg uccugagccc cgacuacguu accgagaagu ccauuucuau gcucgaguuc       60

aaacugggcg ugaugugcca gaacagcauc gccacaaaac uuauuguggu cgaauauaga      120

ccucuggaac acccgcaucc cgggauccuc caacugaagg aguccguguc uuuuguuagc      180

uggaagggag aaaaauccaa gcacucuggc agcaaguucu ggaaagcccu ucggcuggcu      240

cucccucugc gcucccugag cgcgucuucc ggguggaaug agagcuguuc uucccagagc      300

gauauuucuc ucgaccaugu gcagagacgg cgcuccagac ugaaggagcc cccugaacuu      360

cagagcuccg agcgggcugc cggaucuccc ccugccccgg gcacgaugag caaacaccgc      420

gggaagucca gcgcuaccug cagauguugc gucacauacu gugaaggaga gaaccaucug      480

cggaauaaau cucgcgccga gauccacaac caaccccagu gggaaaccca ccucugcaag      540

ccugugcccc aggaguccga aacacagugg auccaaaaug gcaccagacu ggagccuccc      600

gcuccgcaga uuagcgcccu ugcgcugcau cacuuuacag aucucucuaa caauaacgac      660

uucuauaucc uguga                                                       675


<210>  8675
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__Q8WWZ1

<400>  8675

Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp 
1               5                   10                  15      


Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro 
            20                  25                  30          


Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg 
        35                  40                  45              


Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly 
    50                  55                  60                  


Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala 
                85                  90                  95      


Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu 
            100                 105                 110         


Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro 
        115                 120                 125             


Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Glu Gln Ser Trp 
145                 150         


<210>  8676
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__AAK33010

<400>  8676
auguguuccc uccccauggc aagauacuac auaauuaaau augcagacca gaaggcucua       60

uacacaagag auggccagcu gcugguggga gauccuguug cagacaacug cugugcagag      120

aagaucugca uacuuccuaa cagaggcuug gcccgcacca agguccccau uuuccugggg      180

auccagggag ggagccgcug ccuggcaugu guggagacag aagaggggcc uucccuacag      240

cuggaggaug ugaacauuga ggaacuguac aaagguggug aagaggccac acgcuucacc      300

uucuuccaga gcagcucagg cuccgccuuc aggcuugagg cugcugccug gccuggcugg      360

uuccugugug gcccggcaga gccccagcag ccaguacagc ucaccaagga gagugagccc      420

ucagcccgua ccaaguuuua cuuugaacag agcugguag                             459


<210>  8677
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__AAK33010

<400>  8677
augugcagcc ugcccauggc ccgcuacuac aucaucaagu acgccgacca gaaggcgcuc       60

uacacccggg acggccagcu gcuggugggg gacccggucg ccgacaacug cugcgccgag      120

aagaucugca uccuccccaa ccgcggccug gcccggacca aggugcccau cuuccugggg      180

auccagggcg ggucccgcug ccucgccugc guggagacgg aggagggccc cagccugcag      240

cuggaggacg ucaacaucga ggagcucuac aagggcgggg aggaggcgac ccgguucacc      300

uucuuccagu ccagcuccgg cagcgccuuc cgccuggagg ccgccgcgug gccggggugg      360

uuccugugcg gccccgccga gccccagcag cccgugcagc ucaccaagga guccgagccg      420

agcgcccgga cgaaguucua cuucgagcag uccugguga                             459


<210>  8678
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__AAK33010

<400>  8678
augugcuccc uccccauggc ccgcuacuac aucaucaagu acgccgacca gaaggcccuc       60

uacacccgcg acggccagcu ccucgucggc gaccccgucg ccgacaacug cugcgccgag      120

aagaucugca uccuccccaa ccgcggccuc gcccgcacca agguccccau cuuccucggc      180

auccagggcg gcucccgcug ccucgccugc gucgagaccg aggagggccc cucccuccag      240

cucgaggacg ucaacaucga ggagcucuac aagggcggcg aggaggccac ccgcuucacc      300

uucuuccagu ccuccuccgg cuccgccuuc cgccucgagg ccgccgccug gcccggcugg      360

uuccucugcg gccccgccga gccccagcag cccguccagc ucaccaagga guccgagccc      420

uccgcccgca ccaaguucua cuucgagcag uccugguga                             459


<210>  8679
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__AAK33010

<400>  8679
augugcagcc ugcccauggc cagauacuau aucauuaagu acgcugacca gaaagcacuc       60

uauaccaggg auggccaacu ucuggugggg gacccugucg ccgauaacug uugcgcggag      120

aagauaugua ucuugccaaa ucggggauua gcucgcacaa aaguuccgau uuuccugggu      180

auccagggcg ggucccgaug ccuagccugu guggaaacug aggaaggacc cucucuccag      240

cuggaggacg uaaacauuga ggaacuuuac aagggcggug aggaagcaac gcguuuuacc      300

uucuuucagu caaguagcgg guccgccuuc agacuggagg cugcagccug gccuggaugg      360

uuuuugugcg gcccagcuga accccaacag ccugugcagc ucacaaaaga gucugagcca      420

ucggccagga cuaaguucua uuuugaacag ucaugguga                             459


<210>  8680
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__AAK33010

<400>  8680
augugcagcc ugcccauggc cagauacuac aucaucaagu acgccgacca gaaggcccug       60

uacaccagag acggccagcu gcuggugggc gaccccgugg ccgacaacug cugcgccgag      120

aagaucugca uccugcccaa cagaggccug gccagaacca aggugcccau cuuccugggc      180

auccagggcg gcagcagaug ccuggccugc guggagaccg aggagggccc cagccugcag      240

cuggaggacg ugaacaucga ggagcuguac aagggcggcg aggaggccac cagauucacc      300

uucuuccaga gcagcagcgg cagcgccuuc agacuggagg ccgccgccug gcccggcugg      360

uuccugugcg gccccgccga gccccagcag cccgugcagc ugaccaagga gagcgagccc      420

agcgccagaa ccaaguucua cuucgagcag agcugguga                             459


<210>  8681
<211>  459
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__AAK33010

<400>  8681
augugcagcc ugcccauggc cagauacuau aucauuaagu acgcugacca gaaagcccuc       60

uauacccggg auggccaacu gcuugugggg gacccugucg cggauaacug uugcgcugag      120

aagaucugua uucugccgaa ucgcggacuc gccagaacaa aaguucccau cuuccugggc      180

auucaagggg gaucccggug ccuugccugu guggaaacgg aggaaggccc uucucugcag      240

cucgaggacg ugaacaucga ggaacuguac aaagggggag aggaagcuac ccgcuuuaca      300

uucuuucaga gcuccucugg cagcgccuuc agacuggagg cugccgcgug gcccggcugg      360

uuucucugcg ggccugccga accccagcag ccuguccagc ugaccaagga guccgagccg      420

ucugcucgga caaaguucua uuuugaacag agcugguga                             459


<210>  8682
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__Q9NZH7

<400>  8682

Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
                85                  90                  95      


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
            100                 105                 110         


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
        115                 120                 125             


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
    130                 135                 140                 


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
145                 150                 155                 160 


Pro Gly Arg Met 
                


<210>  8683
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__AAF69250

<400>  8683
augaacccac aacgggaggc agcacccaaa uccuaugcua uucgugauuc ucgacagaug       60

gugugggucc ugaguggaaa uucuuuaaua gcagcuccuc uuagccgcag cauuaagccu      120

gucacucuuc auuuaauagc cuguagagac acagaauuca gugacaagga aaaggguaau      180

augguuuacc ugggaaucaa gggaaaagau cucugucucu ucugugcaga aauucagggc      240

aagccuacuu ugcagcuuaa gcuucagggc ucccaagaua acauagggaa ggacacuugc      300

uggaaacuag uuggaauuca cacaugcaua aaccuggaug ugagagagag cugcuucaug      360

ggaacccuug accaaugggg aauaggagug gguagaaaga aguggaagag uuccuuucaa      420

caucaccauc ucaggaagaa ggacaaagau uucucaucca ugcggaccaa cauaggaaug      480

ccaggaagga uguag                                                       495


<210>  8684
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__AAF69250

<400>  8684
augaaccccc agcgcgaggc cgcccccaag agcuacgcga uccgggacuc ccgccagaug       60

gugugggucc ugagcggcaa cucccugauc gccgccccgc ugagccgguc caucaagccc      120

gugacccugc accucaucgc cugccgcgac accgaguuca gcgacaagga gaaggggaac      180

augguguacc ugggcaucaa ggggaaggac cugugccucu ucugcgccga gauccagggc      240

aagcccaccc ugcagcugaa gcuccagggg ucccaggaca acaucggcaa ggacacgugc      300

uggaagcugg ucggcaucca cacgugcauc aaccuggacg ugcgggagag cugcuucaug      360

gggacccucg accagugggg caucggggug ggccgcaaga aguggaaguc cagcuuccag      420

caccaccacc uccggaagaa ggacaaggac uucuccagca ugcgcaccaa caucgggaug      480

ccgggccgga uguga                                                       495


<210>  8685
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__AAF69250

<400>  8685
augaaccccc agcgcgaggc cgcccccaag uccuacgcca uccgcgacuc ccgccagaug       60

gucugggucc ucuccggcaa cucccucauc gccgcccccc ucucccgcuc caucaagccc      120

gucacccucc accucaucgc cugccgcgac accgaguucu ccgacaagga gaagggcaac      180

auggucuacc ucggcaucaa gggcaaggac cucugccucu ucugcgccga gauccagggc      240

aagcccaccc uccagcucaa gcuccagggc ucccaggaca acaucggcaa ggacaccugc      300

uggaagcucg ucggcaucca caccugcauc aaccucgacg uccgcgaguc cugcuucaug      360

ggcacccucg accagugggg caucggcguc ggccgcaaga aguggaaguc cuccuuccag      420

caccaccacc uccgcaagaa ggacaaggac uucuccucca ugcgcaccaa caucggcaug      480

cccggccgca uguga                                                       495


<210>  8686
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__AAF69250

<400>  8686
augaaccccc agagagaggc cgcuccuaag agcuacgcaa ucagggacuc ccggcaaaug       60

gugugggucc ugucuggcaa uucacucauu gccgcgccac uuagucgcag cauaaaaccg      120

guuacccugc acuugaucgc uugccgagau acagaguucu ccgacaagga aaaagggaac      180

augguguauu uaggaauuaa ggguaaagau cugugucuau uuugcgccga aauccagggc      240

aagcccacuc uccagcugaa acuucagggg ucucaagaca auauuggaaa agauacgugu      300

uggaagcugg uaggcaucca uaccugcaua aacuuggacg ugcgugaguc guguuucaug      360

gguacacucg aucagugggg gaucggaguc ggcagaaaga aguggaaaag cucauuucag      420

caccaucacc ugaggaagaa ggacaaagau uucaguucca ugcggacuaa uauuggcaug      480

ccugggcgca uguga                                                       495


<210>  8687
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__AAF69250

<400>  8687
augaaccccc agagagaggc cgcccccaag agcuacgcca ucagagacag cagacagaug       60

gugugggugc ugagcggcaa cagccugauc gccgcccccc ugagcagaag caucaagccc      120

gugacccugc accugaucgc cugcagagac accgaguuca gcgacaagga gaagggcaac      180

augguguacc ugggcaucaa gggcaaggac cugugccugu ucugcgccga gauccagggc      240

aagcccaccc ugcagcugaa gcugcagggc agccaggaca acaucggcaa ggacaccugc      300

uggaagcugg ugggcaucca caccugcauc aaccuggacg ugagagagag cugcuucaug      360

ggcacccugg accagugggg caucggcgug ggcagaaaga aguggaagag cagcuuccag      420

caccaccacc ugagaaagaa ggacaaggac uucagcagca ugagaaccaa caucggcaug      480

cccggcagaa uguga                                                       495


<210>  8688
<211>  495
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__AAF69250

<400>  8688
augaaccccc agagagaggc cgcuccuaag agcuacgcca uccgggacuc ccgccaaaug       60

gugugggucc ugucuggcaa uagccucauu gcggcuccgc uguccagauc uaucaaaccc      120

guuacccuuc accugauugc cugccgggau acagaauuua gcgacaagga gaaagggaac      180

augguguauc ucggaaucaa gggcaaagau cugugucuuu ucugcgccga aauucagggg      240

aagccuacgc ugcagcucaa gcugcaggga ucccaagaca auaucggcaa agauaccugu      300

uggaagcugg uggggaucca uacaugcauu aaccucgacg uccgcgaguc uuguuucaug      360

ggaacccugg aucagugggg caucggcgug gggcggaaaa aguggaaaag cuccuuucag      420

caccaucacc uuagaaagaa ggacaaagau uucagcucua ugcgcacaaa uauuggaaug      480

cccggcagaa uguga                                                       495


<210>  8689
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__Q9UBH0

<400>  8689

Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu 
1               5                   10                  15      


Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His 
            20                  25                  30          


Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg 
        35                  40                  45              


Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly 
    50                  55                  60                  


Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu 
65                  70                  75                  80  


Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys 
                85                  90                  95      


Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala 
    130                 135                 140                 


Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 155 


<210>  8690
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__AAF02757

<400>  8690
augguccuga guggggcgcu gugcuuccga augaaggacu cggcauugaa ggugcuuuau       60

cugcauaaua accagcuucu agcuggaggg cugcaugcag ggaaggucau uaaaggugaa      120

gagaucagcg ugguccccaa ucgguggcug gaugccagcc ugucccccgu cauccugggu      180

guccagggug gaagccagug ccugucaugu gggguggggc aggagccgac ucuaacacua      240

gagccaguga acaucaugga gcucuaucuu ggugccaagg aauccaagag cuucaccuuc      300

uaccggcggg acauggggcu caccuccagc uucgagucgg cugccuaccc gggcugguuc      360

cugugcacgg ugccugaagc cgaucagccu gucagacuca cccagcuucc cgagaauggu      420

ggcuggaaug cccccaucac agacuucuac uuccagcagu gugacuag                   468


<210>  8691
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__AAF02757

<400>  8691
auggugcuga gcggcgcccu cugcuuccgc augaaggacu ccgcccugaa gguccuguac       60

cuccacaaca accagcugcu ggccgggggc cuccacgcgg ggaaggugau caagggcgag      120

gagaucagcg ugguccccaa ccgguggcug gacgccuccc ugagcccggu gauccucggg      180

gugcagggcg gcucccagug ccugagcugc ggggucggcc aggagcccac ccugacccuc      240

gagcccguga acaucaugga gcuguaccug ggggccaagg aguccaagag cuucacguuc      300

uaccgccggg acaugggccu caccuccagc uucgaguccg ccgcguaccc cgggugguuc      360

cugugcaccg ugccggaggc cgaccagccc guccgccuga cccagcuccc cgagaacggc      420

ggcuggaacg cccccaucac ggacuucuac uuccagcagu gcgacuga                   468


<210>  8692
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__AAF02757

<400>  8692
augguccucu ccggcgcccu cugcuuccgc augaaggacu ccgcccucaa gguccucuac       60

cuccacaaca accagcuccu cgccggcggc cuccacgccg gcaaggucau caagggcgag      120

gagaucuccg ucguccccaa ccgcuggcuc gacgccuccc ucucccccgu cauccucggc      180

guccagggcg gcucccagug ccucuccugc ggcgucggcc aggagcccac ccucacccuc      240

gagcccguca acaucaugga gcucuaccuc ggcgccaagg aguccaaguc cuucaccuuc      300

uaccgccgcg acaugggccu caccuccucc uucgaguccg ccgccuaccc cggcugguuc      360

cucugcaccg uccccgaggc cgaccagccc guccgccuca cccagcuccc cgagaacggc      420

ggcuggaacg cccccaucac cgacuucuac uuccagcagu gcgacuga                   468


<210>  8693
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__AAF02757

<400>  8693
auggugcuga gcggcgcccu cugcuucaga augaaggacu ccgcucuuaa aguccuguac       60

uugcacaaca aucaguuacu ggcaggggga cuacaugccg guaagguuau caaaggcgag      120

gaaauuucug ugguacccaa cagguggcuc gaugcgucac ugaguccugu gauacuuggg      180

guccaaggag gcagccagug ucuguccugc gguguggggc aggagccaac cuugacacuc      240

gaaccgguua auaucaugga gcuguaucug ggagcuaagg aaucuaaauc guuuacuuuc      300

uaccggcgcg acaugggccu cacgagcuca uuugagagug ccgcauaucc cggcugguuc      360

uuauguaccg ugccugaggc cgaucagcca guccgacuga cacaacuucc cgaaaacggg      420

ggauggaaug cuccuauuac ugacuuuuac uuccagcagu gcgauuga                   468


<210>  8694
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__AAF02757

<400>  8694
auggugcuga gcggcgcccu gugcuucaga augaaggaca gcgcccugaa ggugcuguac       60

cugcacaaca accagcugcu ggccggcggc cugcacgccg gcaaggugau caagggcgag      120

gagaucagcg uggugcccaa cagauggcug gacgccagcc ugagccccgu gauccugggc      180

gugcagggcg gcagccagug ccugagcugc ggcgugggcc aggagcccac ccugacccug      240

gagcccguga acaucaugga gcuguaccug ggcgccaagg agagcaagag cuucaccuuc      300

uacagaagag acaugggccu gaccagcagc uucgagagcg ccgccuaccc cggcugguuc      360

cugugcaccg ugcccgaggc cgaccagccc gugagacuga cccagcugcc cgagaacggc      420

ggcuggaacg cccccaucac cgacuucuac uuccagcagu gcgacuga                   468


<210>  8695
<211>  468
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__AAF02757

<400>  8695
auggugcuga gcggcgcccu cugcuucaga augaaggacu ccgcucugaa aguccuuuac       60

cugcacaaca aucagcuccu ggccggggga cuucaugcgg gcaagguuau caaaggggag      120

gaaauuucug uggugcccaa ccgguggcug gaugcuagcc ucuccccugu cauccuggga      180

gugcaaggcg ggucucagug ucugagcugc ggaguuggcc aggagccgac ccucacacug      240

gaacccguga auauuaugga gcuuuaucug ggcgccaagg aauccaaauc uuuuacguuc      300

uaccgcagag acauggggcu caccagcucc uuugagagcg ccgcuuaucc uggaugguuc      360

cuguguacag uccccgaggc cgaucagccu gugcggcuua cccaacugcc cgaaaacggc      420

ggguggaaug cuccuaucac agacuuuuac uuccagcagu gcgauuga                   468


<210>  8696
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__Q9UHA7

<400>  8696

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  8697
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1__Homo_sapiens__AAF25211

<400>  8697
auggaaaaag cauugaaaau ugacacaccu cagcagggga gcauucagga uaucaaucau       60

cggguguggg uucuucagga ccagacgcuc auagcagucc cgaggaagga ccguaugucu      120

ccagucacua uugccuuaau cucaugccga cauguggaga cccuugagaa agacagaggg      180

aaccccaucu accugggccu gaauggacuc aaucucugcc ugaugugugc uaaagucggg      240

gaccagccca cacugcagcu gaaggaaaag gauauaaugg auuuguacaa ccaacccgag      300

ccugugaagu ccuuucucuu cuaccacagc cagaguggca ggaacuccac cuucgagucu      360

guggcuuucc cuggcugguu caucgcuguc agcucugaag gaggcugucc ucucauccuu      420

acccaagaac uggggaaagc caacacuacu gacuuugggu uaacuaugcu guuuuaa         477


<210>  8698
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1__Homo_sapiens__AAF25211

<400>  8698
auggagaagg cccugaagau cgacacgccc cagcagggca gcauccagga caucaaccac       60

cgcguguggg uccuccagga ccagacccug aucgccgugc cgcggaagga ccgcaugucc      120

cccgugacca ucgcgcugau cagcugccgg cacgucgaga cccucgagaa ggaccgcggg      180

aaccccaucu accugggccu gaacgggcuc aaccugugcc ugaugugcgc caaggugggc      240

gaccagccca cccuccagcu gaaggagaag gacaucaugg accuguacaa ccagccggag      300

cccgugaagu ccuuccucuu cuaccacagc caguccgggc ggaacagcac cuucgagucc      360

gucgccuucc ccggcugguu caucgccgug agcuccgagg gcgggugccc ccugauccug      420

acgcaggagc ucggcaaggc caacaccacc gacuucgggc ugaccaugcu guucuga         477


<210>  8699
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1__Homo_sapiens__AAF25211

<400>  8699
auggagaagg cccucaagau cgacaccccc cagcagggcu ccauccagga caucaaccac       60

cgcgucuggg uccuccagga ccagacccuc aucgccgucc cccgcaagga ccgcaugucc      120

cccgucacca ucgcccucau cuccugccgc cacgucgaga cccucgagaa ggaccgcggc      180

aaccccaucu accucggccu caacggccuc aaccucugcc ucaugugcgc caaggucggc      240

gaccagccca cccuccagcu caaggagaag gacaucaugg accucuacaa ccagcccgag      300

cccgucaagu ccuuccucuu cuaccacucc caguccggcc gcaacuccac cuucgagucc      360

gucgccuucc ccggcugguu caucgccguc uccuccgagg gcggcugccc ccucauccuc      420

acccaggagc ucggcaaggc caacaccacc gacuucggcc ucaccaugcu cuucuga         477


<210>  8700
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1__Homo_sapiens__AAF25211

<400>  8700
auggagaagg cccugaaaau cgacacaccc cagcaaggca gcauucagga uauaaaccac       60

agaguguggg uccuccagga ccagacccuu aucgcuguuc cuaggaagga ucggaugucc      120

ccagugacua uugcacugau cucuugccgc cauguagaaa cguuggagaa agaccgaggg      180

aauccgauuu acuuaggacu gaacggucua aaucucuguc ugaugugcgc caaggugggc      240

gaucaaccca cccuucagcu gaaagaaaag gacaucaugg auuuguauaa ccagccugag      300

ccagucaagu cauuccucuu uuaccacagu cagagcgggc guaauuccac auucgaaucu      360

guggcguuuc ccggaugguu cauagcuguu ucgucagagg gcgguugucc ucugauccug      420

acucaagagc ucgggaaagc caacaccaca gacuuuggau uaaccaugcu guucuga         477


<210>  8701
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1__Homo_sapiens__AAF25211

<400>  8701
auggagaagg cccugaagau cgacaccccc cagcagggca gcauccagga caucaaccac       60

agaguguggg ugcugcagga ccagacccug aucgccgugc ccagaaagga cagaaugagc      120

cccgugacca ucgcccugau cagcugcaga cacguggaga cccuggagaa ggacagaggc      180

aaccccaucu accugggccu gaacggccug aaccugugcc ugaugugcgc caaggugggc      240

gaccagccca cccugcagcu gaaggagaag gacaucaugg accuguacaa ccagcccgag      300

cccgugaaga gcuuccuguu cuaccacagc cagagcggca gaaacagcac cuucgagagc      360

guggccuucc ccggcugguu caucgccgug agcagcgagg gcggcugccc ccugauccug      420

acccaggagc ugggcaaggc caacaccacc gacuucggcc ugaccaugcu guucuga         477


<210>  8702
<211>  477
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1__Homo_sapiens__AAF25211

<400>  8702
auggagaagg cccugaaaau cgacacaccc cagcaaggca gcauucagga uaucaaccac       60

agaguguggg uccuccagga ccagacccug auugcuguuc cucggaagga ucgcaugucc      120

ccggugacga ucgcccuuau uucuugcaga cauguggaga cccuggagaa agaccggggg      180

aaucccaucu accucggacu gaacggccuu aaucuguguc ucaugugcgc gaaggucggg      240

gaucaaccua cacugcagcu gaaagaaaag gacaucaugg aucucuauaa ccagcccgag      300

ccuguuaaga gcuuccuguu uuaccacucc cagucuggac gcaauagcac cuucgaaucc      360

guggcuuuuc ccggcugguu cauugccgug ucuagcgaag ggggaugucc ucuuauccug      420

acacaagagc ucggcaaagc caacaccaca gacuuuggcc ugaccaugcu uuucuga         477


<210>  8703
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__P14778

<400>  8703

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  8704
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__AAA59137

<400>  8704
augaaagugu uacucagacu uauuuguuuc auagcucuac ugauuucuuc ucuggaggcu       60

gauaaaugca aggaacguga agaaaaaaua auuuuagugu caucugcaaa ugaaauugau      120

guucgucccu guccucuuaa cccaaaugaa cacaaaggca cuauaacuug guauaaagau      180

gacagcaaga caccuguauc uacagaacaa gccuccagga uucaucaaca caaagagaaa      240

cuuugguuug uuccugcuaa gguggaggau ucaggacauu acuauugcgu gguaagaaau      300

ucaucuuacu gccucagaau uaaaauaagu gcaaaauuug uggagaauga gccuaacuua      360

uguuauaaug cacaagccau auuuaagcag aaacuacccg uugcaggaga cggaggacuu      420

gugugcccuu auauggaguu uuuuaaaaau gaaaauaaug aguuaccuaa auuacagugg      480

uauaaggauu gcaaaccucu acuucuugac aauauacacu uuaguggagu caaagauagg      540

cucaucguga ugaauguggc ugaaaagcau agagggaacu auacuuguca ugcauccuac      600

acauacuugg gcaagcaaua uccuauuacc cggguaauag aauuuauuac ucuagaggaa      660

aacaaaccca caaggccugu gauugugagc ccagcuaaug agacaaugga aguagacuug      720

ggaucccaga uacaauugau cuguaauguc accggccagu ugagugacau ugcuuacugg      780

aaguggaaug ggucaguaau ugaugaagau gacccagugc uaggggaaga cuauuacagu      840

guggaaaauc cugcaaacaa aagaaggagu acccucauca cagugcuuaa uauaucggaa      900

auugaaagua gauuuuauaa acauccauuu accuguuuug ccaagaauac acaugguaua      960

gaugcagcau auauccaguu aauauaucca gucacuaauu uccagaagca caugauuggu     1020

auauguguca cguugacagu cauaauugug uguucuguuu ucaucuauaa aaucuucaag     1080

auugacauug ugcuuuggua cagggauucc ugcuaugauu uucucccaau aaaagcuuca     1140

gauggaaaga ccuaugacgc auauauacug uauccaaaga cuguugggga agggucuacc     1200

ucugacugug auauuuuugu guuuaaaguc uugccugagg ucuuggaaaa acagugugga     1260

uauaagcugu ucauuuaugg aagggaugac uacguugggg aagacauugu ugaggucauu     1320

aaugaaaacg uaaagaaaag cagaagacug auuaucauuu uagucagaga aacaucaggc     1380

uucagcuggc ugggugguuc aucugaagag caaauagcca uguauaaugc ucuuguucag     1440

gauggaauua aaguuguccu gcuugagcug gagaaaaucc aagacuauga gaaaaugcca     1500

gaaucgauua aauucauuaa gcagaaacau ggggcuaucc gcuggucagg ggacuuuaca     1560

cagggaccac agucugcaaa gacaagguuc uggaagaaug ucagguacca caugccaguc     1620

cagcgacggu caccuucauc uaaacaccag uuacugucac cagccacuaa ggagaaacug     1680

caaagagagg cucacgugcc ucucggguag                                      1710


<210>  8705
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1R1__Homo_sapiens__AAA59137

<400>  8705
augaaggugc ugcuccgccu gaucugcuuc aucgcccugc ucaucagcuc ccuggaggcc       60

gacaagugca aggagcggga ggagaagauc auccugguca gcuccgcgaa cgagaucgac      120

gugcgccccu gcccgcucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cgcccguguc caccgagcag gccagccgga uccaccagca caaggagaag      240

cugugguucg uccccgccaa gguggaggac uccgggcacu acuacugcgu gguccgcaac      300

agcuccuacu gccugcggau caagaucagc gccaaguucg uggagaacga gccgaaccuc      360

ugcuacaacg cccaggcgau cuucaagcag aagcugcccg uggccggcga cgggggccug      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcugcagugg      480

uacaaggacu gcaagccgcu gcuccuggac aacauccacu ucuccggggu gaaggaccgc      540

cugaucguga ugaacgucgc cgagaagcac cggggcaacu acacgugcca cgccagcuac      600

accuaccucg gcaagcagua ccccaucacc cgcgugaucg aguucaucac ccuggaggag      660

aacaagccca cccggcccgu gaucgucucc ccggcgaacg agaccaugga gguggaccug      720

gggagccaga uccagcucau cugcaacgug acgggccagc uguccgacau cgccuacugg      780

aaguggaacg ggagcgucau cgacgaggac gaccccgugc ugggcgagga cuacuacucc      840

guggagaacc ccgccaacaa gcgccggagc acccucauca ccguccugaa caucuccgag      900

aucgagagcc gcuucuacaa gcaccccuuc acgugcuucg ccaagaacac ccacgggauc      960

gacgccgcgu acauccagcu gaucuacccg gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccucaccgu caucaucgug ugcagcgucu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua ccgggacucc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga cguacgacgc cuacauccuc uaccccaaga ccguggggga gggcuccacc     1200

agcgacugcg acaucuucgu cuucaaggug cugcccgagg ugcuggagaa gcagugcggg     1260

uacaagcugu ucaucuacgg ccgcgacgac uacgucggcg aggacaucgu ggaggugauc     1320

aacgagaacg ucaagaaguc ccggcgccuc aucaucaucc uggugcggga gaccagcggg     1380

uucuccuggc ucggcgggag cuccgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacggcauca aggucgugcu gcucgagcug gagaagaucc aggacuacga gaagaugccg     1500

gagagcauca aguucaucaa gcagaagcac ggggcgaucc gcugguccgg cgacuucacg     1560

cagggccccc agagcgccaa gacccgguuc uggaagaacg ugcgcuacca caugcccguc     1620

cagcggcgcu cccccagcuc caagcaccag cugcucagcc cggccaccaa ggagaagcug     1680

cagcgcgagg cccacgugcc ccugggguga                                      1710


<210>  8706
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1R1__Homo_sapiens__AAA59137

<400>  8706
augaaggucc uccuccgccu caucugcuuc aucgcccucc ucaucuccuc ccucgaggcc       60

gacaagugca aggagcgcga ggagaagauc auccucgucu ccuccgccaa cgagaucgac      120

guccgccccu gcccccucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacuccaaga cccccgucuc caccgagcag gccucccgca uccaccagca caaggagaag      240

cucugguucg uccccgccaa ggucgaggac uccggccacu acuacugcgu cguccgcaac      300

uccuccuacu gccuccgcau caagaucucc gccaaguucg ucgagaacga gcccaaccuc      360

ugcuacaacg cccaggccau cuucaagcag aagcuccccg ucgccggcga cggcggccuc      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcuccagugg      480

uacaaggacu gcaagccccu ccuccucgac aacauccacu ucuccggcgu caaggaccgc      540

cucaucguca ugaacgucgc cgagaagcac cgcggcaacu acaccugcca cgccuccuac      600

accuaccucg gcaagcagua ccccaucacc cgcgucaucg aguucaucac ccucgaggag      660

aacaagccca cccgccccgu caucgucucc cccgccaacg agaccaugga ggucgaccuc      720

ggcucccaga uccagcucau cugcaacguc accggccagc ucuccgacau cgccuacugg      780

aaguggaacg gcuccgucau cgacgaggac gaccccgucc ucggcgagga cuacuacucc      840

gucgagaacc ccgccaacaa gcgccgcucc acccucauca ccguccucaa caucuccgag      900

aucgaguccc gcuucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu caucuacccc gucaccaacu uccagaagca caugaucggc     1020

aucugcguca cccucaccgu caucaucguc ugcuccgucu ucaucuacaa gaucuucaag     1080

aucgacaucg uccucuggua ccgcgacucc ugcuacgacu uccuccccau caaggccucc     1140

gacggcaaga ccuacgacgc cuacauccuc uaccccaaga ccgucggcga gggcuccacc     1200

uccgacugcg acaucuucgu cuucaagguc cuccccgagg uccucgagaa gcagugcggc     1260

uacaagcucu ucaucuacgg ccgcgacgac uacgucggcg aggacaucgu cgaggucauc     1320

aacgagaacg ucaagaaguc ccgccgccuc aucaucaucc ucguccgcga gaccuccggc     1380

uucuccuggc ucggcggcuc cuccgaggag cagaucgcca uguacaacgc ccucguccag     1440

gacggcauca aggucguccu ccucgagcuc gagaagaucc aggacuacga gaagaugccc     1500

gaguccauca aguucaucaa gcagaagcac ggcgccaucc gcugguccgg cgacuucacc     1560

cagggccccc aguccgccaa gacccgcuuc uggaagaacg uccgcuacca caugcccguc     1620

cagcgccgcu cccccuccuc caagcaccag cuccucuccc ccgccaccaa ggagaagcuc     1680

cagcgcgagg cccacguccc ccucggcuga                                      1710


<210>  8707
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1R1__Homo_sapiens__AAA59137

<400>  8707
augaaggugc ugcucagacu uaucugcuuc auugcccugu ugauaagcuc cuuagaggcu       60

gacaaaugua aggaaaggga ggagaaaauc auucuggucu cuucagcaaa cgaaaucgau      120

guucggcccu gcccucuaaa uccaaacgaa cacaagggca ccauuacaug guacaaagac      180

gauaguaaga cuccggugag cacggagcag gccucccgca uccaucaaca caaggagaaa      240

cucugguuug uacccgcgaa gguggaagac ucugggcauu auuacugugu cgugcgaaau      300

ucgucauauu gccugcguau aaaaaucagc gcuaaguucg uugagaacga accuaaucuu      360

uguuacaacg cccaggcaau uuuuaaacag aagcugccag uggccggaga ugguggcuug      420

gucugccccu auauggaguu cuuuaagaau gagaacaaug aacucccuaa acugcagugg      480

uacaaggacu guaaaccacu gcucuuagau aacauccacu ucaguggggu gaaggacaga      540

cugauuguaa ugaauguugc ugagaaacau aggggaaacu auaccugcca cgcauccuac      600

acauaccuug gcaagcaaua ucccaucacu cgggugauag aauuuauuac cuuggaggaa      660

aauaaaccua cacgcccagu caucgugucu ccggccaacg agaccaugga gguggaucug      720

gguagccaga uucagcuaau cuguaauguc acugggcagc ucuccgacau cgcuuacugg      780

aaguggaacg gaucaguuau ugaugaagac gaucccgugc ugggcgagga cuauuacagu      840

guagaaaacc cugccaauaa gagaaggagc acacuuauaa ccgugcugaa caucucugag      900

auugaauccc gguucuauaa acacccauuu acgugcuucg cgaagaauac ucauggcauc      960

gacgcagccu acauacaauu gauuuauccc gucaccaacu uucagaaaca caugaucggg     1020

aucuguguga cacucacugu uauuaucgug ugcucagucu ucauuuacaa gauauuuaaa     1080

aucgauauug ugcuguggua ccgcgacagc ugcuaugauu ucuuaccuau caaggcuagu     1140

gacggaaaga ccuacgaugc cuauauccug uacccaaaaa caguagguga gggcucuacc     1200

uccgacugug auauuuucgu uuuuaaggug cuccccgagg uccuugaaaa acagugcggg     1260

uauaagcugu ucauauacgg acgagacgau uaugugggcg aggacaucgu cgaagugauu     1320

aaugagaacg uuaaaaagag cagaagguug aucauuaucc uagugcggga aacgucgggu     1380

uuuucuuggc ucgggggauc cucagaggag cagauagcaa uguacaaugc ucugguacaa     1440

gauggcauca aggucgugcu gcuugaacug gagaaaauuc aggacuacga aaagaugccg     1500

gagaguauca aauucauuaa gcagaaacau ggcgccaucc guuggagcgg ggacuuuacu     1560

caaggaccuc aguccgcgaa gacacgcuuc uggaagaacg uuagauauca caugcccgug     1620

cagaggcggu cuccaagcuc aaaacaccag uugcucaguc cugccaccaa ggagaaacug     1680

caacgagaag cacauguccc cuuagguuga                                      1710


<210>  8708
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1R1__Homo_sapiens__AAA59137

<400>  8708
augaaggugc ugcugagacu gaucugcuuc aucgcccugc ugaucagcag ccuggaggcc       60

gacaagugca aggagagaga ggagaagauc auccugguga gcagcgccaa cgagaucgac      120

gugagacccu gcccccugaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cccccgugag caccgagcag gccagcagaa uccaccagca caaggagaag      240

cugugguucg ugcccgccaa gguggaggac agcggccacu acuacugcgu ggugagaaac      300

agcagcuacu gccugagaau caagaucagc gccaaguucg uggagaacga gcccaaccug      360

ugcuacaacg cccaggccau cuucaagcag aagcugcccg uggccggcga cggcggccug      420

gugugccccu acauggaguu cuucaagaac gagaacaacg agcugcccaa gcugcagugg      480

uacaaggacu gcaagccccu gcugcuggac aacauccacu ucagcggcgu gaaggacaga      540

cugaucguga ugaacguggc cgagaagcac agaggcaacu acaccugcca cgccagcuac      600

accuaccugg gcaagcagua ccccaucacc agagugaucg aguucaucac ccuggaggag      660

aacaagccca ccagacccgu gaucgugagc cccgccaacg agaccaugga gguggaccug      720

ggcagccaga uccagcugau cugcaacgug accggccagc ugagcgacau cgccuacugg      780

aaguggaacg gcagcgugau cgacgaggac gaccccgugc ugggcgagga cuacuacagc      840

guggagaacc ccgccaacaa gagaagaagc acccugauca ccgugcugaa caucagcgag      900

aucgagagca gauucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu gaucuacccc gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccugaccgu gaucaucgug ugcagcgugu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua cagagacagc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga ccuacgacgc cuacauccug uaccccaaga ccgugggcga gggcagcacc     1200

agcgacugcg acaucuucgu guucaaggug cugcccgagg ugcuggagaa gcagugcggc     1260

uacaagcugu ucaucuacgg cagagacgac uacgugggcg aggacaucgu ggaggugauc     1320

aacgagaacg ugaagaagag cagaagacug aucaucaucc uggugagaga gaccagcggc     1380

uucagcuggc ugggcggcag cagcgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacggcauca agguggugcu gcuggagcug gagaagaucc aggacuacga gaagaugccc     1500

gagagcauca aguucaucaa gcagaagcac ggcgccauca gauggagcgg cgacuucacc     1560

cagggccccc agagcgccaa gaccagauuc uggaagaacg ugagauacca caugcccgug     1620

cagagaagaa gccccagcag caagcaccag cugcugagcc ccgccaccaa ggagaagcug     1680

cagagagagg cccacgugcc ccugggcuga                                      1710


<210>  8709
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1R1__Homo_sapiens__AAA59137

<400>  8709
augaaggugc ugcucagacu gaucugcuuc auugcccuuc ugaucagcuc ccucgaggcu       60

gacaaaugua aggaacggga ggaaaagauu auccuggucu cuagcgccaa cgagauugau      120

guucgccccu gcccucuuaa uccgaacgaa cacaagggca ccaucacaug guacaaagac      180

gauuccaaga cgcccguguc uaccgagcag gcgagcagaa uccaucaaca caaggagaaa      240

cugugguuug ugccugcuaa ggucgaagac uccgggcauu auuacugugu gguucgcaau      300

ucuagcuauu gccuccggau uaaaaucucc gccaaguucg uggagaacga acccaaucug      360

uguuacaacg cccaggcuau uuuuaaacag aagcugccug ucgccggaga uggcgggcuc      420

gugugccccu auauggaguu cuuuaagaau gagaacaaug aacugccuaa acuucagugg      480

uacaaggacu guaaaccgcu gcuccuggau aacauccacu ucagcggagu uaaggacaga      540

cuuauuguga ugaaugucgc ugagaaacau cggggcaacu auacaugcca cgccucuuac      600

accuaccugg ggaagcaaua ucccaucaca cgcgugauug aauuuaucac ccucgaggaa      660

aauaaaccua caagacccgu gaucgucucc ccugcgaacg agaccaugga gguugaucug      720

ggaagccaga uucagcugau cuguaaugug acgggccagc ucucugacau ugccuacugg      780

aaguggaacg gcuccgugau cgaugaagac gaucccgucc ugggggagga cuauuacagc      840

guggaaaacc cggcuaauaa gcggcgcucu acccuuauua caguucugaa caucuccgag      900

aucgaaagca gauucuauaa acacccuuuu accugcuucg ccaagaauac acauggaauu      960

gacgcugccu acauccaacu cauuuauccc gugaccaacu uucagaaaca caugaucggc     1020

auuuguguca cgcugacagu gaucaucguu ugcuccgugu ucauuuacaa gaucuuuaaa     1080

auugauaucg uccuuuggua ccgggacucu ugcuaugauu uccugccuau uaaggcgagc     1140

gacgggaaga ccuacgaugc cuauauccuc uaccccaaaa cagugggaga gggcuccacc     1200

agcgacugug auauuuucgu cuuuaaggug cugcccgagg uucuggaaaa acagugcggg     1260

uauaaacucu ucaucuacgg acgcgacgau uaugugggcg aggacaucgu cgaagugauu     1320

aaugagaacg uuaaaaaguc uagacggcug aucauuaucc uugugcgcga aaccuccggc     1380

uuuagcuggc ucgggggauc uagcgaggag cagauugcua uguacaaugc ccugguccaa     1440

gauggcauca agguggugcu gcuugaacug gagaaaaucc aggacuacga aaagaugccu     1500

gaguccauua aauucaucaa gcagaaacau ggggcuauua gauggucugg agacuuuaca     1560

caaggcccgc agagcgccaa gacgcgguuc uggaagaacg uuagauauca caugcccguc     1620

cagcgccggu ccccuagcuc uaaacaccag cuccuguccc ccgccaccaa ggagaaacug     1680

caaagagaag cucaugugcc ucucggguga                                      1710


<210>  8710
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__Q6NWP5

<400>  8710

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Asn Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Ser Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  8711
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__AAH67508

<400>  8711
augaaagugu uacucagacu uauuuguuuc auagcucuac ugauuucuuc ucuggaggcu       60

gauaaaugca aggaacguga agaaaaaaua auuuuagugu caucugcaaa ugaaauugau      120

guucgucccu guccucuuaa cccaaaugaa cacaaaggca cuauaacuug guauaaagau      180

gacagcaaga caccuguauc uacagaacaa gccuccagga uucaucaaca caaagagaaa      240

cuuugguuug uuccugcuaa gguggaggau ucaggacauu acuauugcgu gguaagaaau      300

ucaucuuacu gccucagaau uaaaauaagu gcaaaauuug uggagaauga gccuaacuua      360

uguuauaaug cacaagccau auuuaagcag aaccuacccg uugcaggaga cggaggacuu      420

gugugcccuu auauggaguu uuuuaaaaau gaaaauaaug aguuaccuaa auuacagugg      480

uauaaggauu gcaaaccucu acuucuugac aauauacacu uuaguggagu caaagauagg      540

cucaucguga ugaauguggc ugaaaagcau agagggaacu auacuuguca ugcauccuac      600

acauacuugg gcaagcaaua uccuauuacc cggguaauag aauuuauuac ucuagaggaa      660

aacaaaccca caaggccugu gauugugagc ccagcuaaug agacaaugga aguagacuug      720

ggaucccaga uacaauugau cuguaauguc accggccagu ugagugacau ugcuuacugg      780

aaguggaaug ggucaguaau ugaugaagau gacccagugc uaggggaaga cuauuacagu      840

guggaaaauc cugcaaacaa aagaaggagu acccucauca cagugcuuaa uauaucggaa      900

auugaaagua gauuuuauaa acauccauuu accuguuuug ccaagaauac acaugguaua      960

gaugcagcau auauccaguu aauauaucca gucacuaauu uccagaagca caugauuggu     1020

auauguguca cguugacagu cauaauugug uguucuguuu ucaucuauaa aaucuucaag     1080

auugacauug ugcuuuggua cagggauucc ugcuaugauu uucucccaau aaaagcuuca     1140

gauggaaaga ccuaugacgc auauauacug uauccaaaga cuguugggga agggucuacc     1200

ucugacugug auauuuuugu guuuaaaguc uugccugagg ucuuggaaaa acagugugga     1260

uauaagcugu ucauuuaugg aagggaugac uacguugggg aagacauugu ugaggucauu     1320

aaugaaaacg uaaagaaaag cagaagacug auuaucauuu uagucagaga aacaucaagc     1380

uucagcuggc ugggugguuc aucugaagag caaauagcca uguauaaugc ucuuguucag     1440

gauggaauua aaguuguccu gcuugagcug gagaaaaucc aagacuauga gaaaaugcca     1500

gaaucgauua aauucauuaa gcagaaacau ggggcuaucc gcuggucagg ggacuuuaca     1560

cagggaccac agucugcaaa gacaagguuc uggaagaaug ucagguacca caugccaguc     1620

cagcgacggu caccuucauc uaaacaccag uuacugucac cagccacuaa ggagaaacug     1680

caaagagagg cucacgugcc ucucggguag                                      1710


<210>  8712
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1R1__Homo_sapiens__AAH67508

<400>  8712
augaaggugc ugcuccgccu gaucugcuuc aucgcccugc ucaucagcuc ccuggaggcc       60

gacaagugca aggagcggga ggagaagauc auccugguca gcuccgcgaa cgagaucgac      120

gugcgccccu gcccgcucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cgcccguguc caccgagcag gccagccgga uccaccagca caaggagaag      240

cugugguucg uccccgccaa gguggaggac uccgggcacu acuacugcgu gguccgcaac      300

agcuccuacu gccugcggau caagaucagc gccaaguucg uggagaacga gccgaaccuc      360

ugcuacaacg cccaggcgau cuucaagcag aaccugcccg uggccggcga cgggggccug      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcugcagugg      480

uacaaggacu gcaagccgcu gcuccuggac aacauccacu ucuccggggu gaaggaccgc      540

cugaucguga ugaacgucgc cgagaagcac cggggcaacu acacgugcca cgccagcuac      600

accuaccucg gcaagcagua ccccaucacc cgcgugaucg aguucaucac ccuggaggag      660

aacaagccca cccggcccgu gaucgucucc ccggcgaacg agaccaugga gguggaccug      720

gggagccaga uccagcucau cugcaacgug acgggccagc uguccgacau cgccuacugg      780

aaguggaacg ggagcgucau cgacgaggac gaccccgugc ugggcgagga cuacuacucc      840

guggagaacc ccgccaacaa gcgccggagc acccucauca ccguccugaa caucuccgag      900

aucgagagcc gcuucuacaa gcaccccuuc acgugcuucg ccaagaacac ccacgggauc      960

gacgccgcgu acauccagcu gaucuacccg gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccucaccgu caucaucgug ugcagcgucu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua ccgggacucc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga cguacgacgc cuacauccuc uaccccaaga ccguggggga gggcuccacc     1200

agcgacugcg acaucuucgu cuucaaggug cugcccgagg ugcuggagaa gcagugcggg     1260

uacaagcugu ucaucuacgg ccgcgacgac uacgucggcg aggacaucgu ggaggugauc     1320

aacgagaacg ucaagaaguc ccggcgccuc aucaucaucc uggugcggga gaccagcucc     1380

uucagcuggc ucgggggcuc cagcgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacgggauca aggucgugcu gcucgagcug gagaagaucc aggacuacga gaagaugccg     1500

gaguccauca aguucaucaa gcagaagcac ggcgcgaucc gcuggagcgg ggacuucacg     1560

cagggccccc aguccgccaa gacccgguuc uggaagaacg ugcgcuacca caugcccguc     1620

cagcggcgca gccccuccag caagcaccag cugcucuccc cggccaccaa ggagaagcug     1680

cagcgcgagg cccacgugcc ccugggcuga                                      1710


<210>  8713
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1R1__Homo_sapiens__AAH67508

<400>  8713
augaaggucc uccuccgccu caucugcuuc aucgcccucc ucaucuccuc ccucgaggcc       60

gacaagugca aggagcgcga ggagaagauc auccucgucu ccuccgccaa cgagaucgac      120

guccgccccu gcccccucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacuccaaga cccccgucuc caccgagcag gccucccgca uccaccagca caaggagaag      240

cucugguucg uccccgccaa ggucgaggac uccggccacu acuacugcgu cguccgcaac      300

uccuccuacu gccuccgcau caagaucucc gccaaguucg ucgagaacga gcccaaccuc      360

ugcuacaacg cccaggccau cuucaagcag aaccuccccg ucgccggcga cggcggccuc      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcuccagugg      480

uacaaggacu gcaagccccu ccuccucgac aacauccacu ucuccggcgu caaggaccgc      540

cucaucguca ugaacgucgc cgagaagcac cgcggcaacu acaccugcca cgccuccuac      600

accuaccucg gcaagcagua ccccaucacc cgcgucaucg aguucaucac ccucgaggag      660

aacaagccca cccgccccgu caucgucucc cccgccaacg agaccaugga ggucgaccuc      720

ggcucccaga uccagcucau cugcaacguc accggccagc ucuccgacau cgccuacugg      780

aaguggaacg gcuccgucau cgacgaggac gaccccgucc ucggcgagga cuacuacucc      840

gucgagaacc ccgccaacaa gcgccgcucc acccucauca ccguccucaa caucuccgag      900

aucgaguccc gcuucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu caucuacccc gucaccaacu uccagaagca caugaucggc     1020

aucugcguca cccucaccgu caucaucguc ugcuccgucu ucaucuacaa gaucuucaag     1080

aucgacaucg uccucuggua ccgcgacucc ugcuacgacu uccuccccau caaggccucc     1140

gacggcaaga ccuacgacgc cuacauccuc uaccccaaga ccgucggcga gggcuccacc     1200

uccgacugcg acaucuucgu cuucaagguc cuccccgagg uccucgagaa gcagugcggc     1260

uacaagcucu ucaucuacgg ccgcgacgac uacgucggcg aggacaucgu cgaggucauc     1320

aacgagaacg ucaagaaguc ccgccgccuc aucaucaucc ucguccgcga gaccuccucc     1380

uucuccuggc ucggcggcuc cuccgaggag cagaucgcca uguacaacgc ccucguccag     1440

gacggcauca aggucguccu ccucgagcuc gagaagaucc aggacuacga gaagaugccc     1500

gaguccauca aguucaucaa gcagaagcac ggcgccaucc gcugguccgg cgacuucacc     1560

cagggccccc aguccgccaa gacccgcuuc uggaagaacg uccgcuacca caugcccguc     1620

cagcgccgcu cccccuccuc caagcaccag cuccucuccc ccgccaccaa ggagaagcuc     1680

cagcgcgagg cccacguccc ccucggcuga                                      1710


<210>  8714
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1R1__Homo_sapiens__AAH67508

<400>  8714
augaaggugc ugcucagacu uaucugcuuc auugcccugu ugauaagcuc cuuagaggcu       60

gacaaaugua aggaaaggga ggagaaaauc auucuggucu cuucagcaaa cgaaaucgau      120

guucggcccu gcccucuaaa uccaaacgaa cacaagggca ccauuacaug guacaaagac      180

gauaguaaga cuccggugag cacggagcag gccucccgca uccaucaaca caaggagaaa      240

cucugguuug uacccgcgaa gguggaagac ucugggcauu auuacugugu cgugcgaaau      300

ucgucauauu gccugcguau aaaaaucagc gcuaaguucg uugagaacga accuaaucuu      360

uguuacaacg cccaggcaau uuuuaaacag aaucugccag uggccggaga ugguggcuug      420

gucugccccu auauggaguu cuuuaagaac gagaauaacg aacucccuaa gcugcagugg      480

uacaaagacu guaagccacu gcucuuagau aauauccacu ucaguggggu gaaagacaga      540

cugauuguaa ugaacguugc ugagaagcau aggggaaauu auaccugcca cgcauccuac      600

acauaccuug gcaaacaaua ucccaucacu cgggugauag aauuuauuac cuuggaggaa      660

aacaagccua cacgcccagu caucgugucu ccggccaaug agaccaugga gguggaucug      720

gguagccaga uucagcuaau cuguaacguc acugggcagc ucuccgacau cgcuuacugg      780

aaauggaacg gaucaguuau ugaugaagac gaucccgugc ugggcgagga cuauuacagu      840

guagaaaauc cugccaacaa gagaaggagc acacuuauaa ccgugcugaa uaucucugag      900

auugaauccc gguucuauaa gcacccauuu acgugcuucg cgaaaaacac ucauggcauc      960

gacgcagccu acauacaauu gauuuauccc gucaccaauu uucagaagca caugaucggg     1020

aucuguguga cacucacugu uauuaucgug ugcucagucu ucauuuacaa aauauuuaag     1080

aucgauauug ugcuguggua ccgcgacagc ugcuaugauu ucuuaccuau caaagcuagu     1140

gacggaaaga ccuacgaugc cuauauccug uacccaaaga caguagguga gggcucuacc     1200

uccgacugug auauuuucgu uuuuaaagug cuccccgagg uccuugaaaa gcagugcggg     1260

uauaaacugu ucauauacgg acgagacgau uaugugggcg aggacaucgu cgaagugauu     1320

aacgagaaug uuaagaaaag cagaagguug aucauuaucc uagugcggga aacgucgucu     1380

uuuuccuggc uggguggguc aagugaggag cagauagcaa uguacaacgc ucucguacaa     1440

gauggaauca aggucgugcu gcuugaacug gagaagauuc aggacuacga gaaaaugccg     1500

gaaagcauca aguucauuaa acagaagcau ggcgccaucc guugguccgg cgacuuuacu     1560

caagggccuc agucugcgaa aacacgcuuc uggaagaaug uuagauauca caugcccgug     1620

cagaggcgga gcccaucaag uaagcaccag uugcucuccc cugccaccaa agagaagcug     1680

caacgagaag cacauguccc cuuaggauga                                      1710


<210>  8715
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1R1__Homo_sapiens__AAH67508

<400>  8715
augaaggugc ugcugagacu gaucugcuuc aucgcccugc ugaucagcag ccuggaggcc       60

gacaagugca aggagagaga ggagaagauc auccugguga gcagcgccaa cgagaucgac      120

gugagacccu gcccccugaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cccccgugag caccgagcag gccagcagaa uccaccagca caaggagaag      240

cugugguucg ugcccgccaa gguggaggac agcggccacu acuacugcgu ggugagaaac      300

agcagcuacu gccugagaau caagaucagc gccaaguucg uggagaacga gcccaaccug      360

ugcuacaacg cccaggccau cuucaagcag aaccugcccg uggccggcga cggcggccug      420

gugugccccu acauggaguu cuucaagaac gagaacaacg agcugcccaa gcugcagugg      480

uacaaggacu gcaagccccu gcugcuggac aacauccacu ucagcggcgu gaaggacaga      540

cugaucguga ugaacguggc cgagaagcac agaggcaacu acaccugcca cgccagcuac      600

accuaccugg gcaagcagua ccccaucacc agagugaucg aguucaucac ccuggaggag      660

aacaagccca ccagacccgu gaucgugagc cccgccaacg agaccaugga gguggaccug      720

ggcagccaga uccagcugau cugcaacgug accggccagc ugagcgacau cgccuacugg      780

aaguggaacg gcagcgugau cgacgaggac gaccccgugc ugggcgagga cuacuacagc      840

guggagaacc ccgccaacaa gagaagaagc acccugauca ccgugcugaa caucagcgag      900

aucgagagca gauucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu gaucuacccc gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccugaccgu gaucaucgug ugcagcgugu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua cagagacagc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga ccuacgacgc cuacauccug uaccccaaga ccgugggcga gggcagcacc     1200

agcgacugcg acaucuucgu guucaaggug cugcccgagg ugcuggagaa gcagugcggc     1260

uacaagcugu ucaucuacgg cagagacgac uacgugggcg aggacaucgu ggaggugauc     1320

aacgagaacg ugaagaagag cagaagacug aucaucaucc uggugagaga gaccagcagc     1380

uucagcuggc ugggcggcag cagcgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacggcauca agguggugcu gcuggagcug gagaagaucc aggacuacga gaagaugccc     1500

gagagcauca aguucaucaa gcagaagcac ggcgccauca gauggagcgg cgacuucacc     1560

cagggccccc agagcgccaa gaccagauuc uggaagaacg ugagauacca caugcccgug     1620

cagagaagaa gccccagcag caagcaccag cugcugagcc ccgccaccaa ggagaagcug     1680

cagagagagg cccacgugcc ccugggcuga                                      1710


<210>  8716
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1R1__Homo_sapiens__AAH67508

<400>  8716
augaaggugc ugcucagacu gaucugcuuc auugcccuuc ugaucagcuc ccucgaggcu       60

gacaaaugua aggaacggga ggaaaagauu auccuggucu cuagcgccaa cgagauugau      120

guucgccccu gcccucuuaa uccgaacgaa cacaagggca ccaucacaug guacaaagac      180

gauuccaaga cgcccguguc uaccgagcag gcgagcagaa uccaucaaca caaggagaaa      240

cugugguuug ugccugcuaa ggucgaagac uccgggcauu auuacugugu gguucgcaau      300

ucuagcuauu gccuccggau uaaaaucucc gccaaguucg uggagaacga acccaaucug      360

uguuacaacg cccaggcuau uuuuaaacag aaucugccug ucgccggaga uggcgggcuc      420

gugugccccu auauggaguu cuuuaagaac gagaauaacg aacugccuaa acuucagugg      480

uacaaagacu guaagccgcu gcuccuggau aauauccacu ucagcggagu uaaagacaga      540

cuuauuguga ugaacgucgc ugagaagcau cggggcaauu auacaugcca cgccucuuac      600

accuaccugg ggaaacaaua ucccaucaca cgcgugauug aauuuaucac ccucgaggaa      660

aacaagccua caagacccgu gaucgucucc ccugcgaaug agaccaugga gguugaucug      720

ggaagccaga uucagcugau cuguaacgug acgggccagc ucucugacau ugccuacugg      780

aaauggaacg gcuccgugau cgaugaagac gaucccgucc ugggggagga cuauuacagc      840

guggaaaauc cggcuaacaa gcggcgcucu acccuuauua caguucugaa uaucuccgag      900

aucgaaagca gauucuauaa gcacccuuuu accugcuucg ccaaaaacac acauggaauu      960

gacgcugccu acauccaacu cauuuauccc gugaccaauu uucagaagca caugaucggc     1020

auuuguguca cgcugacagu gaucaucguu ugcuccgugu ucauuuacaa aaucuuuaag     1080

auugauaucg uccuuuggua ccgggacucu ugcuaugauu uccugccuau uaaagcgagc     1140

gacgggaaga ccuacgaugc cuauauccuc uaccccaaga cagugggaga gggcuccacc     1200

agcgacugug auauuuucgu cuuuaaagug cugcccgagg uucuggaaaa gcagugcggg     1260

uauaaacucu ucaucuacgg acgcgacgau uaugugggcg aggacaucgu cgaagugauu     1320

aacgagaaug uuaagaaauc uagacggcug aucauuaucc uugugcgcga aaccuccagc     1380

uuuucuuggc ugggcgggag cuccgaggag cagauugcua uguacaacgc ccucguccaa     1440

gauggaauca agguggugcu gcuugaacug gagaagaucc aggacuacga gaaaaugccu     1500

gaaucuauua aguucaucaa acagaagcau ggcgcuauua gauggagcgg ggacuuuaca     1560

caaggaccgc aguccgccaa aacgcgguuc uggaagaaug uuagauauca caugcccguc     1620

cagcgccgga gcccuucuuc caagcaccag cuccugagcc ccgccaccaa agagaagcug     1680

caaagagaag cucaugugcc ucucggcuga                                      1710


<210>  8717
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__Q6NWP6

<400>  8717

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Arg His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Gly Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Thr 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  8718
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IL-1R1__Homo_sapiens__AAH67507

<400>  8718
augaaagugu uacucagacu uauuuguuuc auagcucuac ugauuucuuc ucuggaggcu       60

gauaaaugca aggaacguga agaaaaaaua auuuuagugu caucugcaaa ugaaauugau      120

guucgucccu guccucuuaa cccaaaugaa cacaaaggca cuauaacuug guauaaagau      180

gacagcaaga caccuguauc uacagaacaa gccuccagga uucaucaaca caaagagaaa      240

cuuugguuug uuccugcuaa gguggaagau ucaggacauu acuauugcgu gguaagaaau      300

ucaucuuacu gccucagaau uaaaauaagu gcaaaauuug uggagaauga gccuaacuua      360

uguuauaaug cacaagccau auuuaagcag aaacuacccg uugcaggaga cggaggacuu      420

gugugcccuu auauggaguu uuuuaaaaau gaaaauaaug aguuaccuaa auuacagugg      480

uauaaggauu gcaaaccucu acuucuugac aauauacacu uuaguggagu caaagauagg      540

cucaucguga ugaauguggc ugaaaagcau agagggaacu auacucguca ugcauccuac      600

acauacuugg gcaagcaaua uccuauuacc cggguaauag aauuuauuac ucuagaggaa      660

aacaaaccca caaggccugu gauugugagc ccagcuaaug agacaaugga aguagacuug      720

ggaucccaga uacaauugau cuguaauguc accggccagu ugagugacau ugcuuacugg      780

aaguggaaug ggucaguaau ugaugaagau gacccagugc uaggggaaga cuauuacagu      840

guggagaauc cugcaaacaa aagaaggagu acccucauca cagugcuuaa uauaucggaa      900

auugaaagua gauuuuauaa acauccauuu accuguuuug ccaagaauac acaugguaua      960

gaugcagcau auauccaguu aauauaucca gucacuaauu uccagaagca caugauuggu     1020

auauguguca cguugacagu cauaauugug uguucuguuu ucaucuauaa aaucuucaag     1080

auugacauug ugcuuuggua cagggauucc ugcuaugauu uucucccaau aaaagcuuca     1140

gauggaaaga ccuaugacgc auauauacug uauccaaaga cuguugggga agggucuacc     1200

ucugacugug auauuuuugu guuuaaaguc uugccugggg ucuuggaaaa acagugugga     1260

uauaagcugu ucauuuaugg aagggaugac uacguugggg aagacauugu ugaggucauu     1320

aaugaaaacg uaaagaaaag cagaagacug auuaucauuu uagucagaga aacaucaggc     1380

uucagcuggc ugggugguuc aucugaagag caaauagcca uguauaaugc ucuuguucag     1440

gacggaauua aaguuguccu gcuugagcug gagaaaaucc aagacuauga gaaaaugcca     1500

gaaucgauua aauucauuaa gcagaaacau gggacuaucc gcuggucagg ggacuuuaca     1560

cagggaccac agucugcaaa gacaagguuc uggaagaaug ucagauacca caugccaguc     1620

cagcgacggu caccuucauc uaaacaccag uuacugucac cagccacuaa ggagaaacug     1680

caaagagagg cucacgugcc ucucggguag                                      1710


<210>  8719
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IL-1R1__Homo_sapiens__AAH67507

<400>  8719
augaaggugc ugcuccgccu gaucugcuuc aucgcccugc ucaucagcuc ccuggaggcc       60

gacaagugca aggagcggga ggagaagauc auccugguca gcuccgcgaa cgagaucgac      120

gugcgccccu gcccgcucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cgcccguguc caccgagcag gccagccgga uccaccagca caaggagaag      240

cugugguucg uccccgccaa gguggaggac uccgggcacu acuacugcgu gguccgcaac      300

agcuccuacu gccugcggau caagaucagc gccaaguucg uggagaacga gccgaaccuc      360

ugcuacaacg cccaggcgau cuucaagcag aagcugcccg uggccggcga cgggggccug      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcugcagugg      480

uacaaggacu gcaagccgcu gcuccuggac aacauccacu ucuccggggu gaaggaccgc      540

cugaucguga ugaacgucgc cgagaagcac cggggcaacu acacccgcca cgccagcuac      600

accuaccucg gcaagcagua ccccaucacg cgggugaucg aguucaucac ccuggaggag      660

aacaagccca cccgccccgu gaucgucucc ccggcgaacg agaccaugga gguggaccug      720

gggagccaga uccagcucau cugcaacgug acgggccagc uguccgacau cgccuacugg      780

aaguggaacg ggagcgucau cgacgaggac gaccccgugc ugggcgagga cuacuacucc      840

guggagaacc ccgccaacaa gcggcgcagc acccucauca ccguccugaa caucuccgag      900

aucgagagcc gguucuacaa gcaccccuuc acgugcuucg ccaagaacac ccacgggauc      960

gacgccgcgu acauccagcu gaucuacccg gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccucaccgu caucaucgug ugcagcgucu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua ccgcgacucc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga cguacgacgc cuacauccuc uaccccaaga ccguggggga gggcuccacc     1200

agcgacugcg acaucuucgu cuucaaggug cugcccgggg ugcuggagaa gcagugcggc     1260

uacaagcugu ucaucuacgg ccgggacgac uacgucgggg aggacaucgu ggaggugauc     1320

aacgagaacg ucaagaaguc ccgccggcuc aucaucaucc uggugcgcga gaccagcggc     1380

uucuccuggc ucgggggcag cuccgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacgggauca aggucgugcu gcucgagcug gagaagaucc aggacuacga gaagaugccg     1500

gagagcauca aguucaucaa gcagaagcac ggcacgaucc ggugguccgg cgacuucacc     1560

caggggcccc agagcgcgaa gacccgcuuc uggaagaacg ugcgguacca caugcccguc     1620

cagcgccgcu cccccagcuc caagcaccag cugcucagcc cggccaccaa ggagaagcug     1680

cagcgggagg cccacgugcc ccugggcuga                                      1710


<210>  8720
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IL-1R1__Homo_sapiens__AAH67507

<400>  8720
augaaggucc uccuccgccu caucugcuuc aucgcccucc ucaucuccuc ccucgaggcc       60

gacaagugca aggagcgcga ggagaagauc auccucgucu ccuccgccaa cgagaucgac      120

guccgccccu gcccccucaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacuccaaga cccccgucuc caccgagcag gccucccgca uccaccagca caaggagaag      240

cucugguucg uccccgccaa ggucgaggac uccggccacu acuacugcgu cguccgcaac      300

uccuccuacu gccuccgcau caagaucucc gccaaguucg ucgagaacga gcccaaccuc      360

ugcuacaacg cccaggccau cuucaagcag aagcuccccg ucgccggcga cggcggccuc      420

gucugccccu acauggaguu cuucaagaac gagaacaacg agcuccccaa gcuccagugg      480

uacaaggacu gcaagccccu ccuccucgac aacauccacu ucuccggcgu caaggaccgc      540

cucaucguca ugaacgucgc cgagaagcac cgcggcaacu acacccgcca cgccuccuac      600

accuaccucg gcaagcagua ccccaucacc cgcgucaucg aguucaucac ccucgaggag      660

aacaagccca cccgccccgu caucgucucc cccgccaacg agaccaugga ggucgaccuc      720

ggcucccaga uccagcucau cugcaacguc accggccagc ucuccgacau cgccuacugg      780

aaguggaacg gcuccgucau cgacgaggac gaccccgucc ucggcgagga cuacuacucc      840

gucgagaacc ccgccaacaa gcgccgcucc acccucauca ccguccucaa caucuccgag      900

aucgaguccc gcuucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu caucuacccc gucaccaacu uccagaagca caugaucggc     1020

aucugcguca cccucaccgu caucaucguc ugcuccgucu ucaucuacaa gaucuucaag     1080

aucgacaucg uccucuggua ccgcgacucc ugcuacgacu uccuccccau caaggccucc     1140

gacggcaaga ccuacgacgc cuacauccuc uaccccaaga ccgucggcga gggcuccacc     1200

uccgacugcg acaucuucgu cuucaagguc cuccccggcg uccucgagaa gcagugcggc     1260

uacaagcucu ucaucuacgg ccgcgacgac uacgucggcg aggacaucgu cgaggucauc     1320

aacgagaacg ucaagaaguc ccgccgccuc aucaucaucc ucguccgcga gaccuccggc     1380

uucuccuggc ucggcggcuc cuccgaggag cagaucgcca uguacaacgc ccucguccag     1440

gacggcauca aggucguccu ccucgagcuc gagaagaucc aggacuacga gaagaugccc     1500

gaguccauca aguucaucaa gcagaagcac ggcaccaucc gcugguccgg cgacuucacc     1560

cagggccccc aguccgccaa gacccgcuuc uggaagaacg uccgcuacca caugcccguc     1620

cagcgccgcu cccccuccuc caagcaccag cuccucuccc ccgccaccaa ggagaagcuc     1680

cagcgcgagg cccacguccc ccucggcuga                                      1710


<210>  8721
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IL-1R1__Homo_sapiens__AAH67507

<400>  8721
augaaggugc ugcucagacu uaucugcuuc auugcccugu ugauaagcuc cuuagaggcu       60

gacaaaugua aggaaaggga ggagaaaauc auucuggucu cuucagcaaa cgagaucgau      120

guucggcccu gcccucuaaa uccaaacgaa cacaagggca ccauuacaug guacaaagac      180

gauaguaaga cuccggugag cacggagcag gccucccgca uccaucaaca caaggagaaa      240

cucugguuug uacccgcgaa gguggaagac ucugggcauu auuacugugu cgugcgaaau      300

ucgucauauu gccugcguau aaaaaucagc gcuaaguucg uugagaacga accuaaucuu      360

uguuacaacg cccaggcaau uuuuaaacag aagcugccag uggccggaga ugguggcuug      420

gucugccccu auauggaguu cuuuaagaau gagaacaaug aacucccuaa acugcagugg      480

uacaaggacu guaaaccacu gcucuuagau aacauccacu ucaguggggu gaaggacaga      540

cugauuguaa ugaauguugc ugagaaacau aggggaaacu auacccggca cgcauccuac      600

acauaccuug gcaagcaaua ucccaucacu cgcgugauag aauuuauuac cuuggaggaa      660

aauaaaccua caagaccagu caucgugucu ccggccaacg agaccaugga gguggaucug      720

gguagccaga uucagcuaau cugcaauguc acugggcagc ucuccgacau cgcuuacugg      780

aaguggaacg gaucaguuau ugaugaagac gaucccgugc ugggcgagga cuauuacagu      840

guagaaaacc cugccaauaa gaggcggagc acacuuauaa ccgugcugaa caucucugag      900

auugaauccc gcuucuauaa acacccauuu acguguuucg cgaagaauac ucauggcauc      960

gacgcagccu acauacaauu gauuuauccc gucaccaacu uucagaaaca caugaucggg     1020

aucugcguga cacucacugu uauuaucgug uguucagucu ucauuuacaa gauauuuaaa     1080

aucgauauug ugcuguggua ccgagacagc ugcuaugauu ucuuaccuau caaggcuagu     1140

gacggaaaga ccuacgaugc cuauauccug uacccaaaaa caguagguga gggcucuacc     1200

uccgacugcg auauuuucgu uuuuaaggug cuccccgggg uccuugagaa acagugugga     1260

uauaagcugu ucauauacgg cagagacgau uaugugggug aagacaucgu cgaggugauu     1320

aaugaaaacg uuaaaaagag caggcgguug aucauuaucc uagugcguga gacgucgggg     1380

uuuucuuggc ugggaggcuc cucagaagaa cagauagcaa uguacaaugc ucucguacaa     1440

gauggcauca aggucgugcu gcuugagcug gagaaaauuc aggacuacga aaagaugccg     1500

gaaaguauca aauucauuaa gcagaaacau gggacuaucc gcuggagcgg agacuuuaca     1560

caagguccuc aguccgccaa gaccagauuc uggaagaacg uuagguauca caugcccgug     1620

cagcggcgau cuccaagcuc aaaacaccag uugcucaguc cugcgacuaa ggagaaacug     1680

caacgcgagg cccauguccc cuuaggcuga                                      1710


<210>  8722
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IL-1R1__Homo_sapiens__AAH67507

<400>  8722
augaaggugc ugcugagacu gaucugcuuc aucgcccugc ugaucagcag ccuggaggcc       60

gacaagugca aggagagaga ggagaagauc auccugguga gcagcgccaa cgagaucgac      120

gugagacccu gcccccugaa ccccaacgag cacaagggca ccaucaccug guacaaggac      180

gacagcaaga cccccgugag caccgagcag gccagcagaa uccaccagca caaggagaag      240

cugugguucg ugcccgccaa gguggaggac agcggccacu acuacugcgu ggugagaaac      300

agcagcuacu gccugagaau caagaucagc gccaaguucg uggagaacga gcccaaccug      360

ugcuacaacg cccaggccau cuucaagcag aagcugcccg uggccggcga cggcggccug      420

gugugccccu acauggaguu cuucaagaac gagaacaacg agcugcccaa gcugcagugg      480

uacaaggacu gcaagccccu gcugcuggac aacauccacu ucagcggcgu gaaggacaga      540

cugaucguga ugaacguggc cgagaagcac agaggcaacu acaccagaca cgccagcuac      600

accuaccugg gcaagcagua ccccaucacc agagugaucg aguucaucac ccuggaggag      660

aacaagccca ccagacccgu gaucgugagc cccgccaacg agaccaugga gguggaccug      720

ggcagccaga uccagcugau cugcaacgug accggccagc ugagcgacau cgccuacugg      780

aaguggaacg gcagcgugau cgacgaggac gaccccgugc ugggcgagga cuacuacagc      840

guggagaacc ccgccaacaa gagaagaagc acccugauca ccgugcugaa caucagcgag      900

aucgagagca gauucuacaa gcaccccuuc accugcuucg ccaagaacac ccacggcauc      960

gacgccgccu acauccagcu gaucuacccc gugaccaacu uccagaagca caugaucggc     1020

aucugcguga cccugaccgu gaucaucgug ugcagcgugu ucaucuacaa gaucuucaag     1080

aucgacaucg ugcuguggua cagagacagc ugcuacgacu uccugcccau caaggccagc     1140

gacggcaaga ccuacgacgc cuacauccug uaccccaaga ccgugggcga gggcagcacc     1200

agcgacugcg acaucuucgu guucaaggug cugcccggcg ugcuggagaa gcagugcggc     1260

uacaagcugu ucaucuacgg cagagacgac uacgugggcg aggacaucgu ggaggugauc     1320

aacgagaacg ugaagaagag cagaagacug aucaucaucc uggugagaga gaccagcggc     1380

uucagcuggc ugggcggcag cagcgaggag cagaucgcca uguacaacgc ccuggugcag     1440

gacggcauca agguggugcu gcuggagcug gagaagaucc aggacuacga gaagaugccc     1500

gagagcauca aguucaucaa gcagaagcac ggcaccauca gauggagcgg cgacuucacc     1560

cagggccccc agagcgccaa gaccagauuc uggaagaacg ugagauacca caugcccgug     1620

cagagaagaa gccccagcag caagcaccag cugcugagcc ccgccaccaa ggagaagcug     1680

cagagagagg cccacgugcc ccugggcuga                                      1710


<210>  8723
<211>  1710
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IL-1R1__Homo_sapiens__AAH67507

<400>  8723
augaaggugc ugcucagacu gaucugcuuc auugcccuuc ugaucagcuc ccucgaggcu       60

gacaaaugua aggaacggga ggaaaagauu auccuggucu cuagcgccaa cgagauugau      120

guucgccccu gcccucuuaa uccgaacgaa cacaagggca ccaucacaug guacaaagac      180

gauuccaaga cgcccguguc uaccgagcag gcgagcagaa uccaucaaca caaggagaaa      240

cugugguuug ugccugcuaa ggucgaagac uccgggcauu auuacugugu gguucgcaau      300

ucuagcuauu gccuccggau uaaaaucucc gccaaguucg uggagaacga acccaaucug      360

uguuacaacg cccaggcuau uuuuaaacag aagcugccug ucgccggaga uggcgggcuc      420

gugugccccu auauggaguu cuuuaagaau gagaacaaug aacugccuaa acuucagugg      480

uacaaggacu guaaaccgcu gcuccuggau aacauccacu ucagcggagu uaaggacaga      540

cuuauuguga ugaaugucgc ugagaaacau cggggcaacu auacacgcca cgccucuuac      600

accuaccugg ggaagcaaua ucccaucaca agagugauug aauuuaucac ccucgaggaa      660

aauaaaccua cacggcccgu gaucgucucc ccugcgaacg agaccaugga gguugaucug      720

ggaagccaga uucagcugau cugcaaugug acgggccagc ucucugacau ugccuacugg      780

aaguggaacg gcuccgugau cgaugaagac gaucccgucc ugggggagga cuauuacagc      840

guggaaaacc cggcuaauaa gcgcagaucu acccuuauua caguucugaa caucuccgag      900

aucgaaagcc gguucuauaa acacccuuuu accuguuucg ccaagaauac acauggaauu      960

gacgcugccu acauccaacu cauuuauccc gugaccaacu uucagaaaca caugaucggc     1020

auuugcguca cgcugacagu gaucaucguu uguuccgugu ucauuuacaa gaucuuuaaa     1080

auugauaucg uccuuuggua ccgcgacucu ugcuaugauu uccugccuau uaaggcgagc     1140

gacgggaaga ccuacgaugc cuauauccuc uaccccaaaa cagugggaga gggcuccacc     1200

agcgacugcg auauuuucgu cuuuaaggug cugcccgggg uucuggagaa acagugugga     1260

uauaaacucu ucaucuacgg cagagacgau uaugugggcg aagacaucgu cgaggugauu     1320

aaugaaaacg uuaaaaaguc ucggcgccug aucauuaucc uugugagaga gaccuccggg     1380

uuuagcuggc ugggaggcuc uagcgaagaa cagauugcua uguacaaugc ccucguccaa     1440

gaugggauca agguggugcu gcuugagcug gagaaaaucc aggacuacga gaagaugccu     1500

gaauccauua aauucaucaa gcagaaacau ggaacaauuc gguggucugg cgacuuuacg     1560

caagggccgc agagcgcuaa gaccagauuc uggaagaacg uucgcuauca caugcccguc     1620

cagcggagau ccccuagcuc uaaacaccag cuccuguccc ccgccacaaa ggagaaacug     1680

caacgcgagg cccaugugcc ucucggauga                                      1710


<210>  8724
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK1__Homo_sapiens__L8E7M9

<400>  8724

Met Gly Pro Trp Thr Ala Cys Ser Cys Cys Arg Pro Ala Pro Ser Gln 
1               5                   10                  15      


Ala Trp Ala Trp Asn Arg Thr Gly Arg Gly Pro Lys Lys Val Met Asn 
            20                  25                  30          


Phe Arg Ala Asp Val Phe Thr Trp Ala Asp Pro Pro Asn Pro Glu Val 
        35                  40                  45              


Lys Val Leu Met Val Arg Ser Ser His Gly Ala Arg Val Leu Ser Thr 
    50                  55                  60                  


Leu Pro Ala Val Gly Val Gly Ala His Ala Arg Gly Gly Glu Lys Glu 
65                  70                  75                  80  


Val Ala Leu Leu Phe 
                85  


<210>  8725
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK1__Homo_sapiens__CCQ43144

<400>  8725
auggggcccu ggacagccug cagcugcugu cguccagcuc ccucccaggc uugggccugg       60

aacaggacag gcaggggccc gaagaaagug augaauuuca gagcugaugu guucaccugg      120

gcagaucccc caaauccgga agucaaaguu cucaugguca gaaguucuca uggugcacga      180

guccucagca cucugccggc agugggggug ggggcccaug cccgcggggg agagaaggag      240

guggcccugc uguucuag                                                    258


<210>  8726
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK1__Homo_sapiens__CCQ43144

<400>  8726
augggccccu ggaccgccug cagcugcugc cgcccggccc ccucccaggc gugggccugg       60

aaccggaccg ggcgcggccc caagaaggug augaacuucc gggccgacgu cuucacgugg      120

gccgacccgc ccaaccccga ggugaaggug cugauggucc gcagcuccca cggggcccgg      180

gugcucagca cccugcccgc ggugggcguc ggggcccacg cccgcggcgg cgagaaggag      240

guggcccucc uguucuga                                                    258


<210>  8727
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK1__Homo_sapiens__CCQ43144

<400>  8727
augggccccu ggaccgccug cuccugcugc cgccccgccc ccucccaggc cugggccugg       60

aaccgcaccg gccgcggccc caagaagguc augaacuucc gcgccgacgu cuucaccugg      120

gccgaccccc ccaaccccga ggucaagguc cucauggucc gcuccuccca cggcgcccgc      180

guccucucca cccuccccgc cgucggcguc ggcgcccacg cccgcggcgg cgagaaggag      240

gucgcccucc ucuucuga                                                    258


<210>  8728
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK1__Homo_sapiens__CCQ43144

<400>  8728
augggccccu ggaccgccug cagcuguugc agaccugcuc caucccaggc augggccugg       60

aacaggacag ggcggggacc gaagaaagug augaauuucc gcgcggacgu cuuuacuugg      120

gcugaucccc cuaacccaga gguuaaggug cugaugguac gaucuucaca cggugcccgu      180

gugcucagua cgcuucccgc agucggcgug ggggcccaug cuagaggagg cgaaaaagag      240

guugcacugu uguucuga                                                    258


<210>  8729
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK1__Homo_sapiens__CCQ43144

<400>  8729
augggccccu ggaccgccug cagcugcugc agacccgccc ccagccaggc cugggccugg       60

aacagaaccg gcagaggccc caagaaggug augaacuuca gagccgacgu guucaccugg      120

gccgaccccc ccaaccccga ggugaaggug cugaugguga gaagcagcca cggcgccaga      180

gugcugagca cccugcccgc cgugggcgug ggcgcccacg ccagaggcgg cgagaaggag      240

guggcccugc uguucuga                                                    258


<210>  8730
<211>  258
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK1__Homo_sapiens__CCQ43144

<400>  8730
augggccccu ggaccgccug cagcuguugc agaccugcuc cgucccaggc cugggcgugg       60

aaccggacag ggcgcggacc caagaaagug augaauuuca gagcugacgu cuuuacgugg      120

gccgauccuc ccaacccuga gguuaaggug cugauggugc ggucuagcca cggcgcccgc      180

guccucucca cccugcccgc uguggggguu ggagcccaug cuagaggcgg ggaaaaagag      240

guggcccuuc uguucuga                                                    258


<210>  8731
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK1__Homo_sapiens__P51617

<400>  8731

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


<210>  8732
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK1__Homo_sapiens__AAC08756

<400>  8732
auggccgggg ggccgggccc gggggagccc gcagcccccg gcgcccagca cuucuuguac       60

gaggugccgc ccugggucau gugccgcuuc uacaaaguga uggacgcccu ggagcccgcc      120

gacuggugcc aguucgccgc ccugaucgug cgcgaccaga ccgagcugcg gcugugcgag      180

cgcuccgggc agcgcacggc cagcguccug uggcccugga ucaaccgcaa cgcccgugug      240

gccgaccucg ugcacauccu cacgcaccug cagcugcucc gugcgcggga caucaucaca      300

gccuggcacc cucccgcccc gcuuccgucc ccaggcacca cugccccgag gcccagcagc      360

aucccugcac ccgccgaggc cgaggccugg agcccccgga aguugccauc cucagccucc      420

accuuccucu ccccagcuuu uccaggcucc cagacccauu cagggccuga gcucggccug      480

gucccaagcc cugcuucccu guggccucca ccgccaucuc cagccccuuc uucuaccaag      540

ccaggcccag agagcucagu gucccuccug cagggagccc gccccuuucc guuuugcugg      600

ccccucugug agauuucccg gggcacccac aacuucucgg aggagcucaa gaucggggag      660

gguggcuuug ggugcgugua ccgggcggug augaggaaca cgguguaugc ugugaagagg      720

cugaaggaga acgcugaccu ggaguggacu gcagugaagc agagcuuccu gaccgaggug      780

gagcagcugu ccagguuucg ucacccaaac auuguggacu uugcuggcua cugugcucag      840

aacggcuucu acugccuggu guacggcuuc cugcccaacg gcucccugga ggaccgucuc      900

cacugccaga cccaggccug cccaccucuc uccuggccuc agcgacugga cauccuucug      960

gguacagccc gggcaauuca guuucuacau caggacagcc ccagccucau ccauggagac     1020

aucaagaguu ccaacguccu ucuggaugag aggcugacac ccaagcuggg agacuuuggc     1080

cuggcccggu ucagccgcuu ugccgggucc agccccagcc agagcagcau gguggcccgg     1140

acacagacag ugcggggcac ccuggccuac cugcccgagg aguacaucaa gacgggaagg     1200

cuggcugugg acacggacac cuucagcuuu ggggugguag ugcuagagac cuuggcuggu     1260

cagagggcug ugaagacgca cggugccagg accaaguauc ugaaagaccu gguggaagag     1320

gaggcugagg aggcuggagu ggcuuugaga agcacccaga gcacacugca agcaggucug     1380

gcugcagaug ccugggcugc ucccaucgcc augcagaucu acaagaagca ccuggacccc     1440

aggcccgggc ccugcccacc ugagcugggc cugggccugg gccagcuggc cugcugcugc     1500

cugcaccgcc gggccaaaag gaggccuccu augacccagg uguacgagag gcuagagaag     1560

cugcaggcag ugguggcggg ggugcccggg cauucggagg ccgccagcug cauccccccu     1620

uccccgcagg agaacuccua cguguccagc acuggcagag cccacagugg ggcugcucca     1680

uggcagcccc uggcagcgcc aucaggagcc agugcccagg cagcagagca gcugcagaga     1740

ggccccaacc agcccgugga gagugacgag agccuaggcg gccucucugc ugcccugcgc     1800

uccuggcacu ugacuccaag cugcccucug gacccagcac cccucaggga ggccggcugu     1860

ccucaggggg acacggcagg agaaucgagc ugggggagug gcccaggauc ccggcccaca     1920

gccguggaag gacuggcccu uggcagcucu gcaucaucgu cgucagagcc accgcagauu     1980

aucaucaacc cugcccgaca gaagaugguc cagaagcugg cccuguacga ggauggggcc     2040

cuggacagcc ugcagcugcu gucguccagc ucccucccag gcuugggccu ggaacaggac     2100

aggcaggggc ccgaagaaag ugaugaauuu cagagcuga                            2139


<210>  8733
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK1__Homo_sapiens__AAC08756

<400>  8733
auggccggcg ggcccggccc gggggagccc gccgcgcccg gcgcccagca cuuccuguac       60

gaggugcccc cgugggucau gugccgcuuc uacaagguga uggacgcccu cgagcccgcc      120

gacuggugcc aguucgccgc gcugaucgug cgggaccaga ccgagcugcg ccucugcgag      180

cggagcgggc agcgcaccgc cuccguccug uggcccugga ucaaccggaa cgcccgcgug      240

gccgaccugg ugcacauccu cacgcaccuc cagcugcugc gggcgcgcga caucaucacc      300

gccuggcacc cgcccgcgcc ccugcccagc cccggcacca ccgccccgcg gcccuccagc      360

auccccgccc ccgccgaggc cgaggccugg uccccgcgca agcugcccag cuccgccagc      420

acguuccucu cccccgccuu ccccggcagc cagacccacu ccgggccgga gcugggccug      480

guccccagcc ccgcgucccu cuggcccccg ccgcccagcc ccgcccccuc cagcaccaag      540

cccgggcccg aguccagcgu gucccugcug cagggcgccc ggccguuccc cuucugcugg      600

ccccucugcg agaucagccg cgggacccac aacuucagcg aggagcugaa gaucggcgag      660

ggcggguucg gcugcgugua ccgggccguc augcgcaaca cgguguacgc cgugaagcgg      720

cugaaggaga acgcggaccu cgaguggacc gccgucaagc aguccuuccu gaccgaggug      780

gagcagcuga gccgcuuccg gcaccccaac aucguggacu ucgccgggua cugcgcccag      840

aacggcuucu acugccucgu cuacggcuuc cugccgaacg ggucccugga ggaccgccuc      900

cacugccaga cccaggccug cccgccccug agcuggcccc agcggcugga cauccuccug      960

ggcacggcgc gcgccaucca guuccugcac caggacuccc ccagccucau ccacggggac     1020

aucaagucca gcaacgugcu gcuggacgag cggcucaccc ccaagcuggg cgacuucggg     1080

cuggcccgcu ucucccgcuu cgccggcagc ucccccagcc aguccagcau gguggcgcgg     1140

acccagaccg uccgcggcac gcucgccuac cugcccgagg aguacaucaa gaccgggcgg     1200

cuggccgugg acaccgacac cuucuccuuc ggcguggucg ugcucgagac gcuggccggg     1260

cagcgcgccg ugaagaccca cggcgcgcgg accaaguacc ugaaggaccu cgucgaggag     1320

gaggccgagg aggccggggu ggcccugcgc agcacccagu ccacgcugca ggccggccuc     1380

gcggccgacg ccugggccgc cccgaucgcg augcagaucu acaagaagca ccuggacccc     1440

cggcccggcc ccugcccgcc cgagcugggg cugggccucg ggcagcuggc cugcugcugc     1500

cugcaccgcc gggccaagcg ccggccgccc augacccagg ucuacgagcg ccucgagaag     1560

cugcaggccg ugguggcggg cguccccggg cacagcgagg ccgccuccug caucccgccc     1620

agcccccagg agaacagcua cguguccagc accggccggg cccacuccgg cgccgcgccc     1680

uggcagcccc uggccgcccc cagcggggcc uccgcccagg cggccgagca gcuccagcgc     1740

ggcccgaacc agcccgugga gagcgacgag ucccucgggg gccugagcgc cgcccugcgg     1800

uccuggcacc ugacccccag cugcccccug gacccggcgc cccuccgcga ggccggcugc     1860

ccccaggggg acacggccgg cgaguccagc uggggguccg gccccgggag ccggccgacc     1920

gccgucgagg gccuggcccu gggcuccagc gcguccagca gcuccgagcc gccccagauc     1980

aucaucaacc ccgcccgcca gaagauggug cagaagcucg cccuguacga ggacggggcc     2040

cuggacagcc uccagcugcu guccagcucc agccuccccg gccuggggcu ggagcaggac     2100

cggcagggcc ccgaggaguc cgacgaguuc cagagcuga                            2139


<210>  8734
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK1__Homo_sapiens__AAC08756

<400>  8734
auggccggcg gccccggccc cggcgagccc gccgcccccg gcgcccagca cuuccucuac       60

gagguccccc ccugggucau gugccgcuuc uacaagguca uggacgcccu cgagcccgcc      120

gacuggugcc aguucgccgc ccucaucguc cgcgaccaga ccgagcuccg ccucugcgag      180

cgcuccggcc agcgcaccgc cuccguccuc uggcccugga ucaaccgcaa cgcccgcguc      240

gccgaccucg uccacauccu cacccaccuc cagcuccucc gcgcccgcga caucaucacc      300

gccuggcacc cccccgcccc ccuccccucc cccggcacca ccgccccccg ccccuccucc      360

auccccgccc ccgccgaggc cgaggccugg uccccccgca agcuccccuc cuccgccucc      420

accuuccucu cccccgccuu ccccggcucc cagacccacu ccggccccga gcucggccuc      480

guccccuccc ccgccucccu cuggcccccc ccccccuccc ccgcccccuc cuccaccaag      540

cccggccccg aguccuccgu cucccuccuc cagggcgccc gccccuuccc cuucugcugg      600

ccccucugcg agaucucccg cggcacccac aacuucuccg aggagcucaa gaucggcgag      660

ggcggcuucg gcugcgucua ccgcgccguc augcgcaaca ccgucuacgc cgucaagcgc      720

cucaaggaga acgccgaccu cgaguggacc gccgucaagc aguccuuccu caccgagguc      780

gagcagcucu cccgcuuccg ccaccccaac aucgucgacu ucgccggcua cugcgcccag      840

aacggcuucu acugccucgu cuacggcuuc cuccccaacg gcucccucga ggaccgccuc      900

cacugccaga cccaggccug ccccccccuc uccuggcccc agcgccucga cauccuccuc      960

ggcaccgccc gcgccaucca guuccuccac caggacuccc ccucccucau ccacggcgac     1020

aucaaguccu ccaacguccu ccucgacgag cgccucaccc ccaagcucgg cgacuucggc     1080

cucgcccgcu ucucccgcuu cgccggcucc ucccccuccc aguccuccau ggucgcccgc     1140

acccagaccg uccgcggcac ccucgccuac cuccccgagg aguacaucaa gaccggccgc     1200

cucgccgucg acaccgacac cuucuccuuc ggcgucgucg uccucgagac ccucgccggc     1260

cagcgcgccg ucaagaccca cggcgcccgc accaaguacc ucaaggaccu cgucgaggag     1320

gaggccgagg aggccggcgu cgcccuccgc uccacccagu ccacccucca ggccggccuc     1380

gccgccgacg ccugggccgc ccccaucgcc augcagaucu acaagaagca ccucgacccc     1440

cgccccggcc ccugcccccc cgagcucggc cucggccucg gccagcucgc cugcugcugc     1500

cuccaccgcc gcgccaagcg ccgccccccc augacccagg ucuacgagcg ccucgagaag     1560

cuccaggccg ucgucgccgg cguccccggc cacuccgagg ccgccuccug cauccccccc     1620

uccccccagg agaacuccua cgucuccucc accggccgcg cccacuccgg cgccgccccc     1680

uggcagcccc ucgccgcccc cuccggcgcc uccgcccagg ccgccgagca gcuccagcgc     1740

ggccccaacc agcccgucga guccgacgag ucccucggcg gccucuccgc cgcccuccgc     1800

uccuggcacc ucacccccuc cugcccccuc gaccccgccc cccuccgcga ggccggcugc     1860

ccccagggcg acaccgccgg cgaguccucc uggggcuccg gccccggcuc ccgccccacc     1920

gccgucgagg gccucgcccu cggcuccucc gccuccuccu ccuccgagcc cccccagauc     1980

aucaucaacc ccgcccgcca gaagaugguc cagaagcucg cccucuacga ggacggcgcc     2040

cucgacuccc uccagcuccu cuccuccucc ucccuccccg gccucggccu cgagcaggac     2100

cgccagggcc ccgaggaguc cgacgaguuc caguccuga                            2139


<210>  8735
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK1__Homo_sapiens__AAC08756

<400>  8735
auggccggcg ggcccggacc uggugagcca gcugcaccgg gcgcccagca cuuccuguac       60

gaagugcccc cuugggucau gugcagauuu uauaagguua uggacgcgcu cgagccagcu      120

gauugguguc aauucgccgc acuuaucgug agggaccaga ccgaacugcg guugugcgag      180

cgcagcgggc agcgaacagc cuccguauua uggcccugga uuaaccguaa ugcuagagug      240

gcagaucugg uccauauacu aacucaccuc cagcugcuua gggcccggga caucauuacg      300

gcuuggcauc cuccagcgcc ccugccuucu ccaggaacca cagccccgcg ccccucaagu      360

aucccugcac cagccgaagc ugaggccugg agccccagaa aauugccuuc cucugcaucg      420

acuuuucucu caccagcuuu ccccggcagc caaacccaca gugguccgga gcuggggcug      480

gugccuuccc ccgccucucu cuggccaccu cccccaagcc ccgcgccuuc cucaacaaag      540

ccaggaccgg aaaguagcgu uucuuuacug cagggcgcca ggcccuuucc uuucuguugg      600

ccacuuugcg agauuucccg gggcacccau aacuuuucag aagaguugaa aaucggggag      660

ggagguuucg gcugugugua ccgcgcaguc augcgaaaua cuguguaugc uguaaagaga      720

cugaaagaaa acgccgaucu agaguggaca gcuguuaagc agagcuuucu caccgaagug      780

gagcagcuga guagguuccg gcaccccaau auagucgacu uugccgggua cugcgcacaa      840

aacggauucu auugucuugu guacggcuuu cugccuaaug guucuuugga agaucgucuc      900

cacugccaga cgcaggccug uccaccccug uccuggccgc agcgcuuaga cauccugcuc      960

gggacugcua gagcgauuca auuccuucau caggauagcc cuucgcugau ccacggagac     1020

auuaagucuu ccaacguguu gcuagaugag aggcugaccc caaaacucgg cgacuucggc     1080

cuggcacggu uuucacgauu cgccgggagu agccccuccc agucuagcau ggucgcucgc     1140

acacaaacug uuagaggaac ccuugccuau cugccugagg aauacaucaa gacagguagg     1200

uuggcagugg auaccgacac guuuucauuc ggcguagugg uccucgagac ucuggccggg     1260

cagcgggcug ugaaaacaca uggagcccgc accaaguacu uaaaagaccu gguugaagag     1320

gaagcagagg aggcgggcgu ggcucuaaga aguacucagu ccacacucca ggccggucug     1380

gcagccgaug cuugggccgc acccauagcu augcaaauuu auaagaagca ccuugaccca     1440

aggccugggc ccugcccacc ggaauugggc cugggacucg gccagcuggc cuguugcugc     1500

cuucaccguc gggcgaaacg aagaccuccc augacccagg ucuacgagag gcuggaaaag     1560

uugcaggccg ugguagcugg gguuccagga cauagcgagg cagccucuug uauucccccu     1620

ucaccacaag aaaauaguua ugugagcucc acgggucgcg cucacucugg cgccgcaccc     1680

uggcagccuc ucgcggcccc gucgggggcu agcgcccagg cagcugagca gcugcaacgg     1740

ggaccaaacc agcccgucga guccgaugaa ucauuaggcg gucugagugc cgcacuaaga     1800

ucuuggcauc ucaccccuag cugcccacug gaccccgccc cucuuaggga ggcugggugu     1860

ccgcagggcg auacagcggg agaauccuca uggggcagcg ggcccggauc ucgcccaacu     1920

gccguggagg guuuggcacu gggcuccagu gcuucuagcu ccucagagcc uccccagauc     1980

aucaucaauc cagcccgaca gaaaaugguc caaaagcucg cccuguacga agacggggcu     2040

uuagauaguc ugcagcuuuu gagcucgucc ucucucccug gacugggccu agagcaagac     2100

cggcaggguc ccgaagagag cgaugaauuu cagucauga                            2139


<210>  8736
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK1__Homo_sapiens__AAC08756

<400>  8736
auggccggcg gccccggccc cggcgagccc gccgcccccg gcgcccagca cuuccuguac       60

gaggugcccc ccugggugau gugcagauuc uacaagguga uggacgcccu ggagcccgcc      120

gacuggugcc aguucgccgc ccugaucgug agagaccaga ccgagcugag acugugcgag      180

agaagcggcc agagaaccgc cagcgugcug uggcccugga ucaacagaaa cgccagagug      240

gccgaccugg ugcacauccu gacccaccug cagcugcuga gagccagaga caucaucacc      300

gccuggcacc cccccgcccc ccugcccagc cccggcacca ccgcccccag acccagcagc      360

auccccgccc ccgccgaggc cgaggccugg agccccagaa agcugcccag cagcgccagc      420

accuuccuga gccccgccuu ccccggcagc cagacccaca gcggccccga gcugggccug      480

gugcccagcc ccgccagccu guggcccccc ccccccagcc ccgcccccag cagcaccaag      540

cccggccccg agagcagcgu gagccugcug cagggcgcca gacccuuccc cuucugcugg      600

ccccugugcg agaucagcag aggcacccac aacuucagcg aggagcugaa gaucggcgag      660

ggcggcuucg gcugcgugua cagagccgug augagaaaca ccguguacgc cgugaagaga      720

cugaaggaga acgccgaccu ggaguggacc gccgugaagc agagcuuccu gaccgaggug      780

gagcagcuga gcagauucag acaccccaac aucguggacu ucgccggcua cugcgcccag      840

aacggcuucu acugccuggu guacggcuuc cugcccaacg gcagccugga ggacagacug      900

cacugccaga cccaggccug ccccccccug agcuggcccc agagacugga cauccugcug      960

ggcaccgcca gagccaucca guuccugcac caggacagcc ccagccugau ccacggcgac     1020

aucaagagca gcaacgugcu gcuggacgag agacugaccc ccaagcuggg cgacuucggc     1080

cuggccagau ucagcagauu cgccggcagc agccccagcc agagcagcau gguggccaga     1140

acccagaccg ugagaggcac ccuggccuac cugcccgagg aguacaucaa gaccggcaga     1200

cuggccgugg acaccgacac cuucagcuuc ggcguggugg ugcuggagac ccuggccggc     1260

cagagagccg ugaagaccca cggcgccaga accaaguacc ugaaggaccu gguggaggag     1320

gaggccgagg aggccggcgu ggcccugaga agcacccaga gcacccugca ggccggccug     1380

gccgccgacg ccugggccgc ccccaucgcc augcagaucu acaagaagca ccuggacccc     1440

agacccggcc ccugcccccc cgagcugggc cugggccugg gccagcuggc cugcugcugc     1500

cugcacagaa gagccaagag aagacccccc augacccagg uguacgagag acuggagaag     1560

cugcaggccg ugguggccgg cgugcccggc cacagcgagg ccgccagcug cauccccccc     1620

agcccccagg agaacagcua cgugagcagc accggcagag cccacagcgg cgccgccccc     1680

uggcagcccc uggccgcccc cagcggcgcc agcgcccagg ccgccgagca gcugcagaga     1740

ggccccaacc agcccgugga gagcgacgag agccugggcg gccugagcgc cgcccugaga     1800

agcuggcacc ugacccccag cugcccccug gaccccgccc cccugagaga ggccggcugc     1860

ccccagggcg acaccgccgg cgagagcagc uggggcagcg gccccggcag cagacccacc     1920

gccguggagg gccuggcccu gggcagcagc gccagcagca gcagcgagcc cccccagauc     1980

aucaucaacc ccgccagaca gaagauggug cagaagcugg cccuguacga ggacggcgcc     2040

cuggacagcc ugcagcugcu gagcagcagc agccugcccg gccugggccu ggagcaggac     2100

agacagggcc ccgaggagag cgacgaguuc cagagcuga                            2139


<210>  8737
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK1__Homo_sapiens__AAC08756

<400>  8737
auggccggcg ggcccggacc uggcgagccg gcugcccccg gggcgcagca cuuccuguac       60

gaagugccuc ccugggucau gugcagauuu uauaagguua uggacgcucu cgagccugcc      120

gauugguguc aauucgccgc ucugaucgug cgggaccaga ccgaacuucg ccugugcgag      180

agaagcggac agcggacagc cuccgugcuc uggcccugga uuaaccgcaa ugcuagaguc      240

gccgaucugg ugcauauccu uacgcaucug cagcuccugc gggcgcgcga cauuaucacc      300

gccuggcacc cuccggcucc ccugccuucu cccggcacaa ccgccccuag acccagcucc      360

auuccggcuc cugccgaagc ggaggccugg ucuccccgga aacucccuag cuccgcuucu      420

acauuucuga gccccgccuu ccccgggucc caaacccaca gcggaccuga gcuuggccug      480

guuccgucuc ccgcuucccu cuggccuccc ccucccagcc cggccccuuc uuccacaaag      540

cccggcccug aaagcucugu gucccugcuu cagggggccc gccccuuucc uuucuguugg      600

ccccugugcg agaucagcag aggaacccau aacuuuuccg aggagcucaa aaucggcgaa      660

gggggauucg gcugugucua ccgggcugug augcgcaaua cgguuuaugc ggugaagaga      720

cugaaagaaa acgccgaucu ggaguggacc gcugucaagc agucuuuucu cacagaagug      780

gagcagcuga gccgguuccg ccacccgaau auuguggacu uugccgggua cugcgcccaa      840

aacggauucu auugucuugu cuacggcuuu cugccuaaug gcucccucga agauagacug      900

cacugccaga cccaggcuug uccuccccuu agcuggcccc agcggcugga cauccuccug      960

gggacagcca gagcgauuca auuccugcau caggauucuc cgucccucau ccacggagac     1020

auuaagagcu cuaacguucu gcuugaugag cgccugaccc ccaaacucgg cgacuucggg     1080

cuggcucggu uuagcagauu cgccggaucc ucuccuagcc aguccagcau gguggcccgc     1140

acgcaaacag ugcggggcac ccuugcuuau cugcccgagg aauacaucaa gacagggaga     1200

cucgccgucg auaccgacac cuuuucuuuc ggagugguug ugcuggagac acuggcuggc     1260

cagcgcgccg ucaaaacgca uggcgcgcgg accaaguacc ucaaagaccu gguggaagag     1320

gaagccgagg aggcuggggu ugcccuuaga uccacacaga gcacccugca ggcuggacuc     1380

gccgcggaug ccugggcugc cccuauugcu augcaaaucu auaagaagca ccuggacccc     1440

cgcccuggcc ccugcccgcc ugaacugggg cuuggacucg gccagcuggc cuguugcugc     1500

cugcaccgga gagccaaacg ccggcccccu augacacagg uguacgagag acucgaaaag     1560

cugcaggcug ucguggcggg gguccccggc cauucugagg ccgcuuccug uaucccgccu     1620

agcccccaag aaaauuccua ugugucuagc accggacggg cccacuccgg cgccgcuccu     1680

uggcagcccc uugccgcgcc cucuggggcu agcgcccagg ccgcugagca gcugcaacgc     1740

ggaccuaacc agccgguuga guccgaugaa agccucggcg ggcugucugc cgcgcugaga     1800

uccuggcauc uuacgcccag cugcccucuc gaccccgcuc cucugcggga ggccggaugu     1860

ccccagggcg auacagccgg ggaaucuucc uggggcagcg gaccuggcuc uagaccgacc     1920

gcuguggagg ggcuggcccu cggaagcucc gcuucuagcu ccagcgagcc cccucagauu     1980

aucauuaauc ccgcccgcca gaaaaugguc caaaagcugg cgcuuuacga agacggcgcc     2040

cuggauuccc uccagcugcu gucuagcucc ucucuuccug ggcucggacu ggagcaagac     2100

cggcagggcc ccgaagagag cgaugaauuu caguccuga                            2139


<210>  8738
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK2__Homo_sapiens__O43187

<400>  8738

Met Ala Cys Tyr Ile Tyr Gln Leu Pro Ser Trp Val Leu Asp Asp Leu 
1               5                   10                  15      


Cys Arg Asn Met Asp Ala Leu Ser Glu Trp Asp Trp Met Glu Phe Ala 
            20                  25                  30          


Ser Tyr Val Ile Thr Asp Leu Thr Gln Leu Arg Lys Ile Lys Ser Met 
        35                  40                  45              


Glu Arg Val Gln Gly Val Ser Ile Thr Arg Glu Leu Leu Trp Trp Trp 
    50                  55                  60                  


Gly Met Arg Gln Ala Thr Val Gln Gln Leu Val Asp Leu Leu Cys Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Arg Ala Ala Gln Ile Ile Leu Asn Trp Lys Pro Ala 
                85                  90                  95      


Pro Glu Ile Arg Cys Pro Ile Pro Ala Phe Pro Asp Ser Val Lys Pro 
            100                 105                 110         


Glu Lys Pro Leu Ala Ala Ser Val Arg Lys Ala Glu Asp Glu Gln Glu 
        115                 120                 125             


Glu Gly Gln Pro Val Arg Met Ala Thr Phe Pro Gly Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ala Arg Ala His Gln Pro Ala Phe Leu Gln Pro Pro Glu Glu Asp 
145                 150                 155                 160 


Ala Pro His Ser Leu Arg Ser Asp Leu Pro Thr Ser Ser Asp Ser Lys 
                165                 170                 175     


Asp Phe Ser Thr Ser Ile Pro Lys Gln Glu Lys Leu Leu Ser Leu Ala 
            180                 185                 190         


Gly Asp Ser Leu Phe Trp Ser Glu Ala Asp Val Val Gln Ala Thr Asp 
        195                 200                 205             


Asp Phe Asn Gln Asn Arg Lys Ile Ser Gln Gly Thr Phe Ala Asp Val 
    210                 215                 220                 


Tyr Arg Gly His Arg His Gly Lys Pro Phe Val Phe Lys Lys Leu Arg 
225                 230                 235                 240 


Glu Thr Ala Cys Ser Ser Pro Gly Ser Ile Glu Arg Phe Phe Gln Ala 
                245                 250                 255     


Glu Leu Gln Ile Cys Leu Arg Cys Cys His Pro Asn Val Leu Pro Val 
            260                 265                 270         


Leu Gly Phe Cys Ala Ala Arg Gln Phe His Ser Phe Ile Tyr Pro Tyr 
        275                 280                 285             


Met Ala Asn Gly Ser Leu Gln Asp Arg Leu Gln Gly Gln Gly Gly Ser 
    290                 295                 300                 


Asp Pro Leu Pro Trp Pro Gln Arg Val Ser Ile Cys Ser Gly Leu Leu 
305                 310                 315                 320 


Cys Ala Val Glu Tyr Leu His Gly Leu Glu Ile Ile His Ser Asn Val 
                325                 330                 335     


Lys Ser Ser Asn Val Leu Leu Asp Gln Asn Leu Thr Pro Lys Leu Ala 
            340                 345                 350         


His Pro Met Ala His Leu Cys Pro Val Asn Lys Arg Ser Lys Tyr Thr 
        355                 360                 365             


Met Met Lys Thr His Leu Leu Arg Thr Ser Ala Ala Tyr Leu Pro Glu 
    370                 375                 380                 


Asp Phe Ile Arg Val Gly Gln Leu Thr Lys Arg Val Asp Ile Phe Ser 
385                 390                 395                 400 


Cys Gly Ile Val Leu Ala Glu Val Leu Thr Gly Ile Pro Ala Met Asp 
                405                 410                 415     


Asn Asn Arg Ser Pro Val Tyr Leu Lys Asp Leu Leu Leu Ser Asp Ile 
            420                 425                 430         


Pro Ser Ser Thr Ala Ser Leu Cys Ser Arg Lys Thr Gly Val Glu Asn 
        435                 440                 445             


Val Met Ala Lys Glu Ile Cys Gln Lys Tyr Leu Glu Lys Gly Ala Gly 
    450                 455                 460                 


Arg Leu Pro Glu Asp Cys Ala Glu Ala Leu Ala Thr Ala Ala Cys Leu 
465                 470                 475                 480 


Cys Leu Arg Arg Arg Asn Thr Ser Leu Gln Glu Val Cys Gly Ser Val 
                485                 490                 495     


Ala Ala Val Glu Glu Arg Leu Arg Gly Arg Glu Thr Leu Leu Pro Trp 
            500                 505                 510         


Ser Gly Leu Ser Glu Gly Thr Gly Ser Ser Ser Asn Thr Pro Glu Glu 
        515                 520                 525             


Thr Asp Asp Val Asp Asn Ser Ser Leu Asp Ala Ser Ser Ser Met Ser 
    530                 535                 540                 


Val Ala Pro Trp Ala Gly Ala Ala Thr Pro Leu Leu Pro Thr Glu Asn 
545                 550                 555                 560 


Gly Glu Gly Arg Leu Arg Val Ile Val Gly Arg Glu Ala Asp Ser Ser 
                565                 570                 575     


Ser Glu Ala Cys Val Gly Leu Glu Pro Pro Gln Asp Val Thr Glu Thr 
            580                 585                 590         


Ser Trp Gln Ile Glu Ile Asn Glu Ala Lys Arg Lys Leu Met Glu Asn 
        595                 600                 605             


Ile Leu Leu Tyr Lys Glu Glu Lys Val Asp Ser Ile Glu Leu Phe Gly 
    610                 615                 620                 


Pro 
625 


<210>  8739
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK2__Homo_sapiens__AAI25185

<400>  8739
auggccugcu acaucuacca gcugcccucc ugggugcugg acgaccugug ccgcaacaug       60

gacgcgcuca gcgaguggga cuggauggag uucgccuccu acgugaucac agaccugacc      120

cagcugcgga agaucaaguc cauggagcgg gugcagggug ugagcaucac gcgggagcug      180

cugugguggu ggggcaugcg gcaggccacc guccagcaac uuguggaccu ccugugccgc      240

cuggagcucu accgggcugc ccagaucauc cugaacugga aaccggcucc ugaaaucagg      300

ugucccauuc cagccuuccc ugacucugug aagccagaaa agccuuuggc agcuucugua      360

agaaaggcug aggaugaaca ggaagagggg cagccuguga ggauggccac cuuuccaggc      420

ccaggguccu cuccagccag agcccaccag ccggccuuuc uccagccucc ugaagaagau      480

gccccucauu ccuugagaag cgaccucccc acuucgucug auucaaagga cuucagcacc      540

uccauuccua agcaggaaaa acuuuugagc uuggcuggag acagccuuuu cuggagugag      600

gcagacgugg uccaggcaac cgaugacuuc aaucaaaacc gcaaaaucag ccaggggacc      660

uuugcugacg ucuacagagg gcacaggcac gggaagccau ucgucuucaa gaagcucaga      720

gagacagccu guucaagucc aggaucaauc gaaagauucu uccaggcaga guugcagauu      780

ugucuuagau gcugccaccc caaugucuua ccugugcugg gcuucugugc ugcaagacag      840

uuucacagcu ucaucuaccc cuacauggca aaugguuccc uacaggacag acugcagggu      900

caggguggcu cggacccccu ccccuggccc cagcguguca gcaucugcuc agggcugcuc      960

ugugccgucg aguaccugca uggucuggag aucauccaca gcaacgucaa gagcucuaau     1020

gucuugcugg accaaaaucu cacccccaaa cuugcucacc caauggcuca ucuguguccu     1080

gucaacaaaa ggucaaaaua caccaugaug aagacucacc ugcuccggac gucagccgcg     1140

uaucugccag aggauuucau ccgggugggg cagcugacaa agcgagugga caucuucagc     1200

uguggaauag uguuggccga gguccucacg ggcaucccug caauggauaa caaccgaagc     1260

ccgguuuacc ugaaggacuu acuccucagu gauauuccaa gcagcaccgc cucgcucugc     1320

uccaggaaga cgggcgugga gaacgugaug gcaaaggaga ucugccagaa guaccuggag     1380

aagggcgcag ggaggcuucc ggaggacugc gccgaggccc uggccacggc ugccugccug     1440

ugccugcgga ggcguaacac cagccugcag gaggugugug gcucuguggc ugcuguggaa     1500

gagcggcucc gaggucggga gacguugcuc ccuuggagug ggcuuucuga ggguacaggc     1560

ucuucuucca acaccccaga ggaaacagac gacguugaca auuccagccu ugaugccucc     1620

uccuccauga guguggcacc cugggcaggg gcugccaccc cacuucuccc cacagagaau     1680

ggggaaggaa ggcugcgggu caucguggga agggaggcug acuccuccuc ugaggccugu     1740

guuggccugg agccucccca ggauguuaca gaaacuucgu ggcaaauuga gaucaaugag     1800

gccaaaagga aacugaugga gaauauucug cucuacaaag aggaaaaagu ggacagcauu     1860

gagcucuuug gccccuga                                                   1878


<210>  8740
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK2__Homo_sapiens__AAI25185

<400>  8740
auggccugcu acaucuacca gcugcccagc ugggugcucg acgaccugug ccgcaacaug       60

gacgcccugu ccgaguggga cuggauggag uucgcgagcu acgucaucac cgaccucacc      120

cagcugcgga agaucaaguc cauggagcgc gugcagggcg ugagcaucac gcgggagcug      180

cucugguggu gggggaugcg ccaggccacc guccagcagc ugguggaccu gcucugccgg      240

cuggagcugu accgcgccgc ccagaucauc cucaacugga agccggcccc cgagauccgg      300

ugccccaucc ccgcguuccc ggacuccgug aagcccgaga agccccuggc cgccagcguc      360

cgcaaggccg aggacgagca ggaggagggc cagcccgugc ggauggcgac cuucccgggg      420

cccggcucca gccccgcccg cgcccaccag cccgccuucc ugcagccgcc cgaggaggac      480

gcgccccacu cccuccggag cgaccugccc accuccagcg acuccaagga cuucagcacg      540

uccaucccga agcaggagaa gcugcucagc cuggccgggg acucccuguu cuggagcgag      600

gccgacgugg uccaggccac cgacgacuuc aaccagaacc gcaagaucuc ccagggcacc      660

uucgccgacg uguaccgggg ccaccgccac gggaagcccu ucguguucaa gaagcuccgg      720

gagaccgccu gcagcagccc cggcuccauc gagcgcuucu uccaggcgga gcugcagauc      780

ugccugcggu gcugccaccc caacguccuc ccggugcugg gguucugcgc cgcccgccag      840

uuccacagcu ucaucuaccc cuacauggcc aacggcuccc ugcaggaccg gcuccagggg      900

cagggcggca gcgacccccu gcccuggccg cagcgcgugu ccaucugcag cgggcugcuc      960

ugcgccgucg aguaccugca cggccuggag aucauccacu ccaacgucaa gagcuccaac     1020

gugcuccugg accagaaccu gacgcccaag cucgcgcacc ccauggccca ccugugcccc     1080

gugaacaagc ggagcaagua caccaugaug aagacccacc uccuccgcac cuccgccgcc     1140

uaccugccgg aggacuucau ccgcgugggg cagcugacga agcgggugga caucuucagc     1200

ugcggcaucg uccucgccga ggugcugacc ggcauccccg cgauggacaa caaccgcucc     1260

cccguguacc ugaaggaccu ccugcugagc gacaucccgu ccagcaccgc cucccucugc     1320

agccggaaga ccggggucga gaacgugaug gccaaggaga ucugccagaa guaccuggag     1380

aagggcgccg ggcgccugcc cgaggacugc gcggaggccc uggccacggc cgccugccuc     1440

ugccugcggc gccggaacac cucccugcag gaggucugcg gcagcguggc ggccguggag     1500

gagcgccucc gggggcgcga gacccugcug cccuggagcg gccucuccga gggcaccggg     1560

agcuccagca acacgcccga ggagaccgac gacgucgaca acuccagccu ggacgccucc     1620

agcuccauga gcguggcccc gugggccggc gcggccacgc cccugcuccc caccgagaac     1680

ggggagggcc ggcugcgcgu gaucgucggg cgggaggccg acuccagcuc cgaggccugc     1740

gugggccugg agcccccgca ggacgugacc gagaccagcu ggcagaucga gaucaacgag     1800

gccaagcgca agcucaugga gaacauccug cuguacaagg aggagaaggu cgacuccauc     1860

gagcuguucg gccccuga                                                   1878


<210>  8741
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK2__Homo_sapiens__AAI25185

<400>  8741
auggccugcu acaucuacca gcuccccucc uggguccucg acgaccucug ccgcaacaug       60

gacgcccucu ccgaguggga cuggauggag uucgccuccu acgucaucac cgaccucacc      120

cagcuccgca agaucaaguc cauggagcgc guccagggcg ucuccaucac ccgcgagcuc      180

cucugguggu ggggcaugcg ccaggccacc guccagcagc ucgucgaccu ccucugccgc      240

cucgagcucu accgcgccgc ccagaucauc cucaacugga agcccgcccc cgagauccgc      300

ugccccaucc ccgccuuccc cgacuccguc aagcccgaga agccccucgc cgccuccguc      360

cgcaaggccg aggacgagca ggaggagggc cagcccgucc gcauggccac cuuccccggc      420

cccggcuccu cccccgcccg cgcccaccag cccgccuucc uccagccccc cgaggaggac      480

gccccccacu cccuccgcuc cgaccucccc accuccuccg acuccaagga cuucuccacc      540

uccaucccca agcaggagaa gcuccucucc cucgccggcg acucccucuu cugguccgag      600

gccgacgucg uccaggccac cgacgacuuc aaccagaacc gcaagaucuc ccagggcacc      660

uucgccgacg ucuaccgcgg ccaccgccac ggcaagcccu ucgucuucaa gaagcuccgc      720

gagaccgccu gcuccucccc cggcuccauc gagcgcuucu uccaggccga gcuccagauc      780

ugccuccgcu gcugccaccc caacguccuc cccguccucg gcuucugcgc cgcccgccag      840

uuccacuccu ucaucuaccc cuacauggcc aacggcuccc uccaggaccg ccuccagggc      900

cagggcggcu ccgacccccu ccccuggccc cagcgcgucu ccaucugcuc cggccuccuc      960

ugcgccgucg aguaccucca cggccucgag aucauccacu ccaacgucaa guccuccaac     1020

guccuccucg accagaaccu cacccccaag cucgcccacc ccauggccca ccucugcccc     1080

gucaacaagc gcuccaagua caccaugaug aagacccacc uccuccgcac cuccgccgcc     1140

uaccuccccg aggacuucau ccgcgucggc cagcucacca agcgcgucga caucuucucc     1200

ugcggcaucg uccucgccga gguccucacc ggcauccccg ccauggacaa caaccgcucc     1260

cccgucuacc ucaaggaccu ccuccucucc gacauccccu ccuccaccgc cucccucugc     1320

ucccgcaaga ccggcgucga gaacgucaug gccaaggaga ucugccagaa guaccucgag     1380

aagggcgccg gccgccuccc cgaggacugc gccgaggccc ucgccaccgc cgccugccuc     1440

ugccuccgcc gccgcaacac cucccuccag gaggucugcg gcuccgucgc cgccgucgag     1500

gagcgccucc gcggccgcga gacccuccuc cccugguccg gccucuccga gggcaccggc     1560

uccuccucca acacccccga ggagaccgac gacgucgaca acuccucccu cgacgccucc     1620

uccuccaugu ccgucgcccc cugggccggc gccgccaccc cccuccuccc caccgagaac     1680

ggcgagggcc gccuccgcgu caucgucggc cgcgaggccg acuccuccuc cgaggccugc     1740

gucggccucg agccccccca ggacgucacc gagaccuccu ggcagaucga gaucaacgag     1800

gccaagcgca agcucaugga gaacauccuc cucuacaagg aggagaaggu cgacuccauc     1860

gagcucuucg gccccuga                                                   1878


<210>  8742
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK2__Homo_sapiens__AAI25185

<400>  8742
auggccugcu acaucuauca gcugcccagc ugggugcucg acgaucuuug uagaaacaug       60

gacgcucugu ccgaguggga uuggauggaa uuugcaucuu acgucauuac cgacuugaca      120

caauuaagga agauaaaauc aauggagcgg guucagggcg ugaguaucac ucgcgaacug      180

cuaugguggu gggggaugcg acaggccacg guacagcaac ucguggaucu gcuuugccgu      240

cuggaguugu auagagcggc ucagauuauc cucaauugga agccugcccc agaaauuagg      300

uguccgaucc ccgcauuucc ugacagcguc aaaccagaga agccccuggc cgcuuccgug      360

cggaaagcag aggaugaaca ggaggaagga cagccuguuc gcauggccac cuucccaggu      420

cccgggucuu cgccugcuag agcccaccaa ccagcguuuc ugcagccgcc cgaggaggac      480

gcaccucauu cacucaggag cgauuuacca acaaguuccg acucuaagga uuucagcacu      540

uccauaccca agcaggaaaa acugcuuuca uuggccggcg acagucuguu uuggagcgag      600

gcugaugugg uccaggccac cgacgacuuc aaccaaaauc ggaagaucuc ucagggaaca      660

uuugcagaug uguaccgcgg ccaccgacau gguaaaccuu ucguauuuaa gaaacuaaga      720

gaaaccgcuu gcuccucacc agggagcauu gagagguucu uucaggccga acuccaaauc      780

ugucugcggu gcugucaccc caacguucuu ccggugcugg gauucugcgc ggcccgucag      840

uuucauaguu ucauuuaucc uuacauggca aauggcucuu ugcaggaccg ccuccagggc      900

caagggggau ccgauccccu gccauggccu cagagaguca gcaucuguuc ggguuuacug      960

ugcgcugugg aguaucucca cggccuugag auaauucacu cuaacgugaa guccucaaau     1020

guccuguugg accagaaccu aacucccaag cuggcccauc caauggcuca ccucuguccc     1080

guuaauaaaa ggaguaagua cacaaugaug aaaacccauc ugcuucggac gagcgccgca     1140

uaccugccug aagauuucau ccgagugggg caguugacua agcgcguaga cauuuucucc     1200

ugcggaaucg ugcucgccga gguccugacc ggcaucccag cuauggauaa caauagaucu     1260

ccgguguauu uaaaagaccu gcuacucagc gauauucccu caaguacagc gucccugugc     1320

agcaggaaga cugguguuga aaacgugaug gcaaaagaga uaugucaaaa guaccuugaa     1380

aagggggccg gacgguugcc ugaggacugc gcugaggccc uggcaaccgc cgcuugucuc     1440

ugccugcgca gaaggaauac aucucuucag gaagucugug gcucaguggc cgcaguagag     1500

gaacgucugc ggggccgaga gaccuugcuc ccauggagug ggcugagcga aggaacgggu     1560

uccucuucga acacucccga ggagacagau gacguugaca auagcuccuu agaugcguca     1620

aguucuauga gcguggcucc uugggccggc gcagccaccc cacugcuacc cacugaaaac     1680

ggggagggaa gacucagggu caucgugggc cgcgaagcug acuccucaag cgaggccugc     1740

gucggucugg agccgccuca ggaugugaca gaaaccucuu ggcagauuga gaucaacgaa     1800

gcaaaacgga agcucaugga gaauauauug cuguauaaag aagagaaggu ugacuccauu     1860

gagcuuuucg ggccauga                                                   1878


<210>  8743
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK2__Homo_sapiens__AAI25185

<400>  8743
auggccugcu acaucuacca gcugcccagc ugggugcugg acgaccugug cagaaacaug       60

gacgcccuga gcgaguggga cuggauggag uucgccagcu acgugaucac cgaccugacc      120

cagcugagaa agaucaagag cauggagaga gugcagggcg ugagcaucac cagagagcug      180

cugugguggu ggggcaugag acaggccacc gugcagcagc ugguggaccu gcugugcaga      240

cuggagcugu acagagccgc ccagaucauc cugaacugga agcccgcccc cgagaucaga      300

ugccccaucc ccgccuuccc cgacagcgug aagcccgaga agccccuggc cgccagcgug      360

agaaaggccg aggacgagca ggaggagggc cagcccguga gaauggccac cuuccccggc      420

cccggcagca gccccgccag agcccaccag cccgccuucc ugcagccccc cgaggaggac      480

gccccccaca gccugagaag cgaccugccc accagcagcg acagcaagga cuucagcacc      540

agcaucccca agcaggagaa gcugcugagc cuggccggcg acagccuguu cuggagcgag      600

gccgacgugg ugcaggccac cgacgacuuc aaccagaaca gaaagaucag ccagggcacc      660

uucgccgacg uguacagagg ccacagacac ggcaagcccu ucguguucaa gaagcugaga      720

gagaccgccu gcagcagccc cggcagcauc gagagauucu uccaggccga gcugcagauc      780

ugccugagau gcugccaccc caacgugcug cccgugcugg gcuucugcgc cgccagacag      840

uuccacagcu ucaucuaccc cuacauggcc aacggcagcc ugcaggacag acugcagggc      900

cagggcggca gcgacccccu gcccuggccc cagagaguga gcaucugcag cggccugcug      960

ugcgccgugg aguaccugca cggccuggag aucauccaca gcaacgugaa gagcagcaac     1020

gugcugcugg accagaaccu gacccccaag cuggcccacc ccauggccca ccugugcccc     1080

gugaacaaga gaagcaagua caccaugaug aagacccacc ugcugagaac cagcgccgcc     1140

uaccugcccg aggacuucau cagagugggc cagcugacca agagagugga caucuucagc     1200

ugcggcaucg ugcuggccga ggugcugacc ggcauccccg ccauggacaa caacagaagc     1260

cccguguacc ugaaggaccu gcugcugagc gacaucccca gcagcaccgc cagccugugc     1320

agcagaaaga ccggcgugga gaacgugaug gccaaggaga ucugccagaa guaccuggag     1380

aagggcgccg gcagacugcc cgaggacugc gccgaggccc uggccaccgc cgccugccug     1440

ugccugagaa gaagaaacac cagccugcag gaggugugcg gcagcguggc cgccguggag     1500

gagagacuga gaggcagaga gacccugcug cccuggagcg gccugagcga gggcaccggc     1560

agcagcagca acacccccga ggagaccgac gacguggaca acagcagccu ggacgccagc     1620

agcagcauga gcguggcccc cugggccggc gccgccaccc cccugcugcc caccgagaac     1680

ggcgagggca gacugagagu gaucgugggc agagaggccg acagcagcag cgaggccugc     1740

gugggccugg agccccccca ggacgugacc gagaccagcu ggcagaucga gaucaacgag     1800

gccaagagaa agcugaugga gaacauccug cuguacaagg aggagaaggu ggacagcauc     1860

gagcuguucg gccccuga                                                   1878


<210>  8744
<211>  1878
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK2__Homo_sapiens__AAI25185

<400>  8744
auggccugcu acaucuauca gcugcccagc ugggugcucg acgaucugug uagaaacaug       60

gacgcucuuu ccgaguggga uuggauggag uucgccucuu acgucauuac cgaccugaca      120

caacuccgga agaucaaaag cauggaacgc guucagggcg uguccauuac gagagaacug      180

cuuugguggu gggggaugcg gcaggcgacc gugcagcaac uggucgaucu ccugugccgc      240

cuggagcucu auagagcugc ccagaucauu cugaauugga agccugcccc ggaaauccgg      300

ugucccaucc cugcuuuucc cgacucugug aaaccugaga agccccuugc cgcuagcguu      360

cgcaaagccg aggaugaaca ggaggaagga cagccuguga gaauggcgac auucccgggc      420

cccggguccu cuccugcccg ggcucaccaa cccgccuuuc ugcagccucc cgaggaggac      480

gcuccgcaua gccuccgcuc cgaucugccu accagcucug acuccaagga uuucagcaca      540

ucuauuccca agcaggaaaa acuucugucc cucgccggag acagccuguu uuggucugag      600

gcggaugucg ugcaggccac cgacgacuuc aaccaaaaua gaaagaucuc ccagggcaca      660

uuugcugaug uuuaccgggg gcaccgccau ggaaaaccuu ucguguuuaa gaaacugaga      720

gaaaccgccu gcagcucccc cggcucuauu gagcgguucu uucaggcuga acuccaaauc      780

ugucugcgcu gcugucaccc caacguccuu ccugugcugg gcuucugcgc cgccagacag      840

uuucauagcu ucauuuaucc guacauggcu aauggguccc uccaggaccg gcugcaggga      900

caaggcggga gcgauccccu uccuuggccc cagagagugu cuaucuguuc cggacugcuc      960

ugcgcggucg aguaucugca cggccuggag auuauccaca gcaacguuaa gucuagcaau     1020

gugcuccugg accagaaccu uacgccuaag cuggcccauc ccauggcuca ccucuguccg     1080

gugaauaaac gcuccaagua caccaugaug aaaacacauc ugcuucggac cucugccgcc     1140

uaccugccug aagauuucau cagagucggg cagcucacaa agcgcgugga cauuuuuagc     1200

ugcggaaucg uucuggcuga ggugcugacc ggcauucccg ccauggauaa caaucggucc     1260

ccugucuauc ucaaagaccu gcuucugagc gauauccccu cuuccacggc gagccucugc     1320

ucuagaaaga caggcgugga aaacguuaug gcuaaagaga uuugucaaaa guaccuggaa     1380

aagggggccg gacgccugcc ugaggacugc gccgaggcuc uugccaccgc ugccugucuc     1440

ugccugcgga gacgcaauac aucccugcag gaagugugug gcagcgucgc ggccguggag     1500

gaacggcuca gagggcgcga gacccugcuu cccugguccg gacugucuga aggcaccggg     1560

agcuccucua acacaccgga ggagacggau gacgucgaca auagcucccu cgaugcuucu     1620

agcuccauga gcguggcccc uugggcugga gccgcgacac cccugcugcc caccgaaaac     1680

ggcgagggcc ggcuuagagu uaucgugggg cgggaagccg acucuuccag cgaggcuugc     1740

gucggacucg agccuccgca ggaugugacc gaaacaucuu ggcagaucga gauuaacgaa     1800

gccaaacgca agcugaugga gaauauccug cucuauaaag aagagaaggu ugacagcauu     1860

gagcuguucg gccccuga                                                   1878


<210>  8745
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__Q69FE3

<400>  8745

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu 
    290                 295                 300                 


Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser 
                325                 330                 335     


Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr 
            340                 345                 350         


Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser 
        355                 360                 365             


Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu 
    370                 375                 380                 


Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys 
385                 390                 395                 400 


Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys 
                405                 410                 415     


Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val 
            420                 425                 430         


Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys 
        435                 440                 445             


Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
    450                 455                 460 


<210>  8746
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__AAR02358

<400>  8746
augaacaaac ccauaacacc aucaacauau gugcgcugcc ucaauguugg acuaauuagg       60

aagcugucag auuuuauuga uccucaagaa ggauggaaga aguuagcugu agcuauuaaa      120

aaaccaucug gugaugauag auacaaucag uuucacauaa ggagauuuga agcauuacuu      180

caaacuggaa aaagucccac uucugaauua cuguuugacu ggggcaccac aaauugcaca      240

guuggugauc uuguggaucu uuugauccaa aaugaauuuu uugcuccugc gagucuuuug      300

cucccagaug cuguucccaa aacugcuaau acacuaccuu cuaaagaagc uauaacaguu      360

cagcaaaaac agaugccuuu cugugacaaa gacaggacau ugaugacacc ugugcagaau      420

cuugaacaaa gcuauaugcc accugacucc ucaaguccag aaaauaaaag uuuagaaguu      480

agugauacac guuuucacag uuuuucauuu uaugaauuga agaaugucac aaauaacuuu      540

gaugaacgac ccauuucugu uggugguaau aaaaugggag agggaggauu uggaguugua      600

uauaaaggcu acguaaauaa cacaacugug gcagugaaga agcuugcagc aaugguugac      660

auuacuacug aagaacugaa acagcaguuu gaucaagaaa uaaaaguaau ggcaaagugu      720

caacaugaaa acuuaguaga acuacuuggu uucucaagug auggagauga ccucugcuua      780

guauauguuu acaugccuaa ugguucauug cuagacagac ucucuugcuu ggaugguacu      840

ccaccacuuu cuuggcacau gagaugcaag auugcucagg gugcagcuaa uggcaucaau      900

uuucuacaug aaaaucauca uauucauaga gauauuaaaa gugcaaauau cuuacuggau      960

gaagcuuuua cugcuaaaau aucugacuuu ggccuugcac gggcuucuga gaaguuugcc     1020

cagacaguca ugacuagcag aauuguggga acaacagcuu auauggcacc agaagcuuug     1080

cguggagaaa uaacacccaa aucugauauu uacagcuuug gugugguuuu acuagaaaua     1140

auaacuggac uuccagcugu ggaugaacac cgugaaccuc aguuauugcu agauauuaaa     1200

gaagaaauug aagaugaaga aaagacaauu gaagauuaua uugauaaaaa gaugaaugau     1260

gcugauucca cuucaguuga agcuauguac ucuguugcua gucaaugucu gcaugaaaag     1320

aaaaauaaga gaccagacau uaagaagguu caacagcugc ugcaagagau gacagcuucu     1380

uaa                                                                   1383


<210>  8747
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK4__Homo_sapiens__AAR02358

<400>  8747
augaacaagc ccaucacccc gagcaccuac gugcgcugcc ugaacgucgg ccucauccgg       60

aagcuguccg acuucaucga cccccaggag ggguggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgaccg cuacaaccag uuccacaucc ggcgcuucga ggcgcuccug      180

cagacgggga agucccccac cagcgagcuc cuguucgacu ggggcaccac caacugcacg      240

gugggggacc uggucgaccu gcucauccag aacgaguucu ucgccccggc cucccugcug      300

cuccccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc gaucaccgug      360

cagcagaagc agaugccguu cugcgacaag gaccggacgc ugaugacccc cguccagaac      420

cucgagcagu ccuacaugcc gcccgacagc uccagccccg agaacaaguc ccuggaggug      480

agcgacaccc gcuuccacuc cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagcggc ccaucuccgu cggcggcaac aagauggggg agggcggguu cggcguggug      600

uacaaggggu acgucaacaa cacgaccgug gccgugaaga agcucgccgc cauggucgac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggugau ggcgaagugc      720

cagcacgaga accuggugga gcuccugggc uucagcuccg acggcgacga ccugugccuc      780

gucuacgugu acaugcccaa cgggagccug cuggaccgcc ucuccugccu ggacggcacg      840

cccccgcuga gcuggcacau gcggugcaag aucgcccagg gggccgccaa cggcaucaac      900

uuccuccacg agaaccacca cauccaccgc gacaucaaga gcgccaacau ccugcuggac      960

gaggcguuca ccgccaagau cuccgacuuc ggccucgccc gggccagcga gaaguucgcc     1020

cagaccguga ugaccucccg caucgucggg acgaccgcgu acauggcccc cgaggcccug     1080

cggggcgaga ucacccccaa gagcgacauc uacuccuucg ggguggugcu gcucgagauc     1140

aucaccggcc ugcccgccgu cgacgagcac cgcgagccgc agcugcuccu ggacaucaag     1200

gaggagaucg aggacgagga gaagacgauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacagca ccuccgugga ggcgauguac agcgucgccu cccagugccu gcacgagaag     1320

aagaacaagc ggcccgacau caagaaggug cagcagcucc ugcaggagau gaccgccagc     1380

uga                                                                   1383


<210>  8748
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK4__Homo_sapiens__AAR02358

<400>  8748
augaacaagc ccaucacccc cuccaccuac guccgcugcc ucaacgucgg ccucauccgc       60

aagcucuccg acuucaucga cccccaggag ggcuggaaga agcucgccgu cgccaucaag      120

aagcccuccg gcgacgaccg cuacaaccag uuccacaucc gccgcuucga ggcccuccuc      180

cagaccggca agucccccac cuccgagcuc cucuucgacu ggggcaccac caacugcacc      240

gucggcgacc ucgucgaccu ccucauccag aacgaguucu ucgcccccgc cucccuccuc      300

cuccccgacg ccguccccaa gaccgccaac acccuccccu ccaaggaggc caucaccguc      360

cagcagaagc agaugcccuu cugcgacaag gaccgcaccc ucaugacccc cguccagaac      420

cucgagcagu ccuacaugcc ccccgacucc uccucccccg agaacaaguc ccucgagguc      480

uccgacaccc gcuuccacuc cuucuccuuc uacgagcuca agaacgucac caacaacuuc      540

gacgagcgcc ccaucuccgu cggcggcaac aagaugggcg agggcggcuu cggcgucguc      600

uacaagggcu acgucaacaa caccaccguc gccgucaaga agcucgccgc cauggucgac      660

aucaccaccg aggagcucaa gcagcaguuc gaccaggaga ucaaggucau ggccaagugc      720

cagcacgaga accucgucga gcuccucggc uucuccuccg acggcgacga ccucugccuc      780

gucuacgucu acaugcccaa cggcucccuc cucgaccgcc ucuccugccu cgacggcacc      840

cccccccucu ccuggcacau gcgcugcaag aucgcccagg gcgccgccaa cggcaucaac      900

uuccuccacg agaaccacca cauccaccgc gacaucaagu ccgccaacau ccuccucgac      960

gaggccuuca ccgccaagau cuccgacuuc ggccucgccc gcgccuccga gaaguucgcc     1020

cagaccguca ugaccucccg caucgucggc accaccgccu acauggcccc cgaggcccuc     1080

cgcggcgaga ucacccccaa guccgacauc uacuccuucg gcgucguccu ccucgagauc     1140

aucaccggcc uccccgccgu cgacgagcac cgcgagcccc agcuccuccu cgacaucaag     1200

gaggagaucg aggacgagga gaagaccauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacucca ccuccgucga ggccauguac uccgucgccu cccagugccu ccacgagaag     1320

aagaacaagc gccccgacau caagaagguc cagcagcucc uccaggagau gaccgccucc     1380

uga                                                                   1383


<210>  8749
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK4__Homo_sapiens__AAR02358

<400>  8749
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauuagg       60

aaacuuuccg acuucauaga uccacaggag ggguggaaga aacuggccgu ugcuaucaag      120

aaaccgucug gagacgaucg guauaaccaa uuucacauuc gccgauucga agcauuguua      180

cagacuggua agucacccac gagugagcug cuauuugacu ggggcaccac aaauuguacu      240

gugggggauc ucguagaccu gcuuauccag aacgaguucu uugccccugc gagccuguug      300

cucccagaug cugugcccaa gaccgccaau acacugccuu ccaaagaagc aauuaccguc      360

cagcaaaagc agaugccauu cugcgacaaa gaucguacuc ugaugacacc cgugcagaac      420

cucgaacagu cuuacaugcc uccagacucg ucaagcccgg agaauaagag uuuagagguu      480

uccgauacca gauuucauuc uuucagcuuu uaugaacuga aaaacgugac gaauaacuuc      540

gacgagaggc ccaucuccgu cggaggcaau aagaugggug aagggggauu uggcguggua      600

uacaagggcu auguuaacaa uacuaccgug gccgucaaaa aguuggcugc aaugguggau      660

auaacaacug aggagcuuaa acaacaguuc gaccaggaaa ucaaggugau ggccaaaugu      720

cagcacgaga accuggucga acuacucggg uuuucaagug acggagauga ccugugccuu      780

guuuacgugu auaugccuaa ugguagccug uuggaucggc ucucuugucu ggacggcacc      840

ccacccuuau ccuggcauau gcgcugcaag auugcucaag gggccgcgaa cggaaucaac      900

uuccugcacg agaaucauca cauucacaga gauaucaaau cagcaaacau acuccuugac      960

gaagccuuca cagcuaagau uagcgauuuu ggccuggcca gggcaaguga gaaguucgcu     1020

cagaccguaa ugacgucucg gaucgugggu acuacagccu acauggcgcc ugaggccuug     1080

cgcggggaaa uuaccccaaa auccgacauc uacagcuuug gagucgugcu acuggagauc     1140

auuacuggcc uccccgcagu ugaugaacau cgagagccgc agcugcuucu ggacauaaag     1200

gaagagaucg aggaugaaga gaaaacaauu gaagacuaua ucgacaagaa aaugaaugau     1260

gcugacucga ccucugugga ggccauguac uccgucgcuu cacaauguuu gcacgaaaag     1320

aagaacaaaa gaccugauau aaagaaagug cagcagcucc ugcaggagau gacggccagu     1380

uga                                                                   1383


<210>  8750
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK4__Homo_sapiens__AAR02358

<400>  8750
augaacaagc ccaucacccc cagcaccuac gugagaugcc ugaacguggg ccugaucaga       60

aagcugagcg acuucaucga cccccaggag ggcuggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgacag auacaaccag uuccacauca gaagauucga ggcccugcug      180

cagaccggca agagccccac cagcgagcug cuguucgacu ggggcaccac caacugcacc      240

gugggcgacc ugguggaccu gcugauccag aacgaguucu ucgcccccgc cagccugcug      300

cugcccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugcccuu cugcgacaag gacagaaccc ugaugacccc cgugcagaac      420

cuggagcaga gcuacaugcc ccccgacagc agcagccccg agaacaagag ccuggaggug      480

agcgacacca gauuccacag cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagagac ccaucagcgu gggcggcaac aagaugggcg agggcggcuu cggcguggug      600

uacaagggcu acgugaacaa caccaccgug gccgugaaga agcuggccgc caugguggac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggugau ggccaagugc      720

cagcacgaga accuggugga gcugcugggc uucagcagcg acggcgacga ccugugccug      780

guguacgugu acaugcccaa cggcagccug cuggacagac ugagcugccu ggacggcacc      840

cccccccuga gcuggcacau gagaugcaag aucgcccagg gcgccgccaa cggcaucaac      900

uuccugcacg agaaccacca cauccacaga gacaucaaga gcgccaacau ccugcuggac      960

gaggccuuca ccgccaagau cagcgacuuc ggccuggcca gagccagcga gaaguucgcc     1020

cagaccguga ugaccagcag aaucgugggc accaccgccu acauggcccc cgaggcccug     1080

agaggcgaga ucacccccaa gagcgacauc uacagcuucg gcguggugcu gcuggagauc     1140

aucaccggcc ugcccgccgu ggacgagcac agagagcccc agcugcugcu ggacaucaag     1200

gaggagaucg aggacgagga gaagaccauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacagca ccagcgugga ggccauguac agcguggcca gccagugccu gcacgagaag     1320

aagaacaaga gacccgacau caagaaggug cagcagcugc ugcaggagau gaccgccagc     1380

uga                                                                   1383


<210>  8751
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK4__Homo_sapiens__AAR02358

<400>  8751
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauucgg       60

aaacuguccg acuucaucga uccgcaggag ggguggaaga aacuugccgu ugcuauuaag      120

aaacccucug gagacgaucg cuauaaccaa uuucacauca gacgguucga agcccugcuc      180

cagacgggca agagcccuac cuccgagcug cuuuuugacu gggggacaac caauuguaca      240

gugggagauc ugguggaccu ccugauucag aacgaguucu uugcgcccgc uucucugcuc      300

cugccugaug ccguccccaa gaccgccaau acacuuccua gcaaagaagc uaucaccgug      360

cagcaaaagc agaugccguu cugcgacaaa gaucgcacgc ugaugacccc cguucagaac      420

cucgaacagu ccuacaugcc ucccgacucu agcuccccug agaauaagag ccuggaggug      480

ucugauacaa gauuucauuc cuucagcuuu uaugaacuua aaaacgucac caauaacuuc      540

gacgagcggc ccaucucugu gggcgggaau aagaugggag aaggcggcuu ugggguugug      600

uacaagggau augucaacaa uacaaccgug gccgugaaaa agcuggcugc cauggucgau      660

auuacgacag aggagcucaa acaacaguuc gaccaggaaa ucaagguuau ggcgaaaugu      720

cagcacgaga accuggugga acugcucggc uuuuccagcg acggggauga ccugugccuu      780

guguacgucu auaugccgaa uggaucucug cucgaucgcc uguccugucu ugacggcacc      840

ccuccccuga gcuggcauau gagaugcaag auugcccaag gggcugccaa cggaaucaac      900

uuccuccacg agaaucauca cauucaccgg gauaucaaau ccgcuaacau ucugcuggac      960

gaagccuuca cagcgaagau cucugauuuu ggccucgccc gcgcuagcga gaaguucgcc     1020

cagaccguga ugaccuccag aaucguuggc acaacggcuu acauggcccc ugaggcccug     1080

cgcggggaaa uuacccccaa aagcgacauc uacucuuuug gagugguccu ucuggagauu     1140

aucacaggcc uccccgcugu ggaugaacau cgggagccuc agcugcuucu ggacauuaag     1200

gaagagaucg aggaugaaga gaaaaccauc gaagacuaua uugacaagaa aaugaaugau     1260

gcggacucca caagcguuga ggccauguac ucuguggcua gccaaugucu ccacgaaaag     1320

aagaacaaaa gaccggauau caagaaaguc cagcagcugc ugcaggagau gaccgccucc     1380

uga                                                                   1383


<210>  8752
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__Q7Z6A7

<400>  8752

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Ala Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Asn 
        195                 200                 205             


Cys Gly Ser Glu Glu Ala Cys Ser Asn Gly 
    210                 215             


<210>  8753
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__AAP57090

<400>  8753
augaacaaac ccauaacacc aucaacauau gugcgcugcc ucaauguugg acuaauuagg       60

aagcugucag auuuuauuga uccucaagaa ggauggaaga aguuagcugu agcuauuaaa      120

aaaccaucug gugaugauag auacaaucag uuucacauaa ggagauuuga agcauuacuu      180

caaacuggaa aaagucccac uucugaauua cuguuugacu ggggcaccac aaauugcaca      240

gcuggugauc uuguggaucu uuugauccaa aaugaauuuu uugcuccugc gagucuuuug      300

cucccagaug cuguucccaa aacugcuaau acacuaccuu cuaaagaagc uauaacaguu      360

cagcaaaaac agaugccuuu cugugacaaa gacaggacau ugaugacacc ugugcagaau      420

cuugaacaaa gcuauaugcc accugacucc ucaaguccag aaaauaaaag uuuagaaguu      480

agugauacac guuuucacag uuuuucauuu uaugaauuga agaaugucac aaauaacuuu      540

gaugaacgac ccauuucugu uggugguaau aaaaugggag agggaggauu uggaguugua      600

uauaaaggcu acguaaauaa caacuguggc agugaagaag cuugcagcaa ugguuga         657


<210>  8754
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK4__Homo_sapiens__AAP57090

<400>  8754
augaacaagc ccaucacccc gagcaccuac gugcgcugcc ugaacgucgg ccucauccgg       60

aagcuguccg acuucaucga cccccaggag ggguggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgaccg cuacaaccag uuccacaucc ggcgcuucga ggcgcuccug      180

cagacgggga agucccccac cagcgagcuc cuguucgacu ggggcaccac caacugcacg      240

gccggggacc ugguggaccu gcucauccag aacgaguucu ucgccccggc cucccugcug      300

cuccccgacg ccguccccaa gaccgcgaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugccguu cugcgacaag gaccggacgc ugaugacccc cgugcagaac      420

cucgagcagu ccuacaugcc gcccgacagc uccagccccg agaacaaguc ccuggagguc      480

agcgacaccc gcuuccacuc cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagcggc ccaucuccgu gggcggcaac aagauggggg agggcggguu cggcgucgug      600

uacaaggggu acgugaacaa caacugcggc agcgaggagg ccugcuccaa cggcuga         657


<210>  8755
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK4__Homo_sapiens__AAP57090

<400>  8755
augaacaagc ccaucacccc cuccaccuac guccgcugcc ucaacgucgg ccucauccgc       60

aagcucuccg acuucaucga cccccaggag ggcuggaaga agcucgccgu cgccaucaag      120

aagcccuccg gcgacgaccg cuacaaccag uuccacaucc gccgcuucga ggcccuccuc      180

cagaccggca agucccccac cuccgagcuc cucuucgacu ggggcaccac caacugcacc      240

gccggcgacc ucgucgaccu ccucauccag aacgaguucu ucgcccccgc cucccuccuc      300

cuccccgacg ccguccccaa gaccgccaac acccuccccu ccaaggaggc caucaccguc      360

cagcagaagc agaugcccuu cugcgacaag gaccgcaccc ucaugacccc cguccagaac      420

cucgagcagu ccuacaugcc ccccgacucc uccucccccg agaacaaguc ccucgagguc      480

uccgacaccc gcuuccacuc cuucuccuuc uacgagcuca agaacgucac caacaacuuc      540

gacgagcgcc ccaucuccgu cggcggcaac aagaugggcg agggcggcuu cggcgucguc      600

uacaagggcu acgucaacaa caacugcggc uccgaggagg ccugcuccaa cggcuga         657


<210>  8756
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK4__Homo_sapiens__AAP57090

<400>  8756
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauuagg       60

aaacuuuccg acuucauaga uccacaggag ggguggaaga aacuggccgu ugcuaucaag      120

aaaccgucug gagacgaucg guauaaccaa uuucacauuc gccgauucga agcauuguua      180

cagacuggua agucacccac gagugagcug cuauuugacu ggggcaccac aaauuguacu      240

gccggggauc ucguggaccu gcuuauccag aacgaguucu uugcgccugc uagccuguug      300

cucccagaug ccguacccaa gaccgcaaau acacugccuu ccaaagaagc cauuaccgug      360

cagcaaaagc agaugccauu cugcgacaaa gaucguacuc ugaugacacc cguccagaac      420

cucgaacagu cuuacaugcc uccagacucg ucaagcccgg agaauaagag uuuagaggug      480

uccgauacca gauuucauuc uuucagcuuu uaugaacuga aaaacguuac gaauaacuuc      540

gacgagaggc ccaucuccgu gggaggcaau aagaugggug aagggggauu uggcgucgug      600

uacaagggcu auguaaacaa uaacuguggg ucagaggagg cuugcaguaa uggauga         657


<210>  8757
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK4__Homo_sapiens__AAP57090

<400>  8757
augaacaagc ccaucacccc cagcaccuac gugagaugcc ugaacguggg ccugaucaga       60

aagcugagcg acuucaucga cccccaggag ggcuggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgacag auacaaccag uuccacauca gaagauucga ggcccugcug      180

cagaccggca agagccccac cagcgagcug cuguucgacu ggggcaccac caacugcacc      240

gccggcgacc ugguggaccu gcugauccag aacgaguucu ucgcccccgc cagccugcug      300

cugcccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugcccuu cugcgacaag gacagaaccc ugaugacccc cgugcagaac      420

cuggagcaga gcuacaugcc ccccgacagc agcagccccg agaacaagag ccuggaggug      480

agcgacacca gauuccacag cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagagac ccaucagcgu gggcggcaac aagaugggcg agggcggcuu cggcguggug      600

uacaagggcu acgugaacaa caacugcggc agcgaggagg ccugcagcaa cggcuga         657


<210>  8758
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK4__Homo_sapiens__AAP57090

<400>  8758
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauucgg       60

aaacuguccg acuucaucga uccgcaggag ggguggaaga aacuugccgu ugcuauuaag      120

aaacccucug gagacgaucg cuauaaccaa uuucacauca gacgguucga agcccugcuc      180

cagacgggca agagcccuac cuccgagcug cuuuuugacu gggggacaac caauuguaca      240

gcgggagauc ugguggaccu ccugauucag aacgaguucu uugcucccgc cucucugcuc      300

cugccugaug ccgugcccaa gaccgcuaau acacuuccua gcaaagaagc caucaccguc      360

cagcaaaagc agaugccguu cugcgacaaa gaucgcacgc ugaugacccc cgugcagaac      420

cucgaacagu ccuacaugcc ucccgacucu agcuccccug agaauaagag ccuggagguu      480

ucugauacaa gauuucauuc cuucagcuuu uaugaacuua aaaacgugac caauaacuuc      540

gacgagcggc ccaucucugu cggcgggaau aagaugggag aaggcggcuu uggggugguu      600

uacaagggau augugaacaa uaacuguggc uccgaggagg cuugcagcaa uggguga         657


<210>  8759
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__Q7Z6A8

<400>  8759

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Ala Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala 
    290         


<210>  8760
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__AAP57089

<400>  8760
augaacaaac ccauaacacc aucaacauau gugcgcugcc ucaauguugg acuaauuagg       60

aagcugucag auuuuauuga uccucaagaa ggauggaaga aguuagcugu agcuauuaaa      120

aaaccaucug gugaugauag auacaaucag uuucacauaa ggagauuuga agcauuacuu      180

caaacuggaa aaagucccac uucugaauua cuguuugacu ggggcaccac aaauugcaca      240

gcuggugauc uuguggaucu uuugauccaa aaugaauuuu uugcuccugc gagucuuuug      300

cucccagaug cuguucccaa aacugcuaau acacuaccuu cuaaagaagc uauaacaguu      360

cagcaaaaac agaugccuuu cugugacaaa gacaggacau ugaugacacc ugugcagaau      420

cuugaacaaa gcuauaugcc accugacucc ucaaguccag aaaauaaaag uuuagaaguu      480

agugauacac guuuucacag uuuuucauuu uaugaauuga agaaugucac aaauaacuuu      540

gaugaacgac ccauuucugu uggugguaau aaaaugggag agggaggauu uggaguugua      600

uauaaaggcu acguaaauaa cacaacugug gcagugaaga agcuugcagc aaugguugac      660

auuacuacug aagaacugaa acagcaguuu gaucaagaaa uaaaaguaau ggcaaagugu      720

caacaugaaa acuuaguaga acuacuuggu uucucaagug auggagauga ccucugcuua      780

guauauguuu acaugccuaa ugguucauug cuagacagac ucucuugcuu ggaugguacu      840

ccaccacuuu cuuggcacau gagaugcaag auugcuuag                             879


<210>  8761
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK4__Homo_sapiens__AAP57089

<400>  8761
augaacaagc ccaucacccc gagcaccuac gugcgcugcc ugaacgucgg ccucauccgg       60

aagcuguccg acuucaucga cccccaggag ggguggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgaccg cuacaaccag uuccacaucc ggcgcuucga ggcgcuccug      180

cagacgggga agucccccac cagcgagcuc cuguucgacu ggggcaccac caacugcacg      240

gccggggacc ugguggaccu gcucauccag aacgaguucu ucgccccggc cucccugcug      300

cuccccgacg ccguccccaa gaccgcgaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugccguu cugcgacaag gaccggacgc ugaugacccc cgugcagaac      420

cucgagcagu ccuacaugcc gcccgacagc uccagccccg agaacaaguc ccuggagguc      480

agcgacaccc gcuuccacuc cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagcggc ccaucuccgu gggcggcaac aagauggggg agggcggguu cggcgucgug      600

uacaaggggu acgugaacaa cacgaccguc gccgugaaga agcucgccgc gaugguggac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggucau ggccaagugc      720

cagcacgaga accuggugga gcuccugggc uucagcuccg acggcgacga ccugugccuc      780

guguacgucu acaugcccaa cgggagccug cuggaccgcc ucuccugccu ggacggcacg      840

cccccgcuga gcuggcacau gcggugcaag aucgccuga                             879


<210>  8762
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK4__Homo_sapiens__AAP57089

<400>  8762
augaacaagc ccaucacccc cuccaccuac guccgcugcc ucaacgucgg ccucauccgc       60

aagcucuccg acuucaucga cccccaggag ggcuggaaga agcucgccgu cgccaucaag      120

aagcccuccg gcgacgaccg cuacaaccag uuccacaucc gccgcuucga ggcccuccuc      180

cagaccggca agucccccac cuccgagcuc cucuucgacu ggggcaccac caacugcacc      240

gccggcgacc ucgucgaccu ccucauccag aacgaguucu ucgcccccgc cucccuccuc      300

cuccccgacg ccguccccaa gaccgccaac acccuccccu ccaaggaggc caucaccguc      360

cagcagaagc agaugcccuu cugcgacaag gaccgcaccc ucaugacccc cguccagaac      420

cucgagcagu ccuacaugcc ccccgacucc uccucccccg agaacaaguc ccucgagguc      480

uccgacaccc gcuuccacuc cuucuccuuc uacgagcuca agaacgucac caacaacuuc      540

gacgagcgcc ccaucuccgu cggcggcaac aagaugggcg agggcggcuu cggcgucguc      600

uacaagggcu acgucaacaa caccaccguc gccgucaaga agcucgccgc cauggucgac      660

aucaccaccg aggagcucaa gcagcaguuc gaccaggaga ucaaggucau ggccaagugc      720

cagcacgaga accucgucga gcuccucggc uucuccuccg acggcgacga ccucugccuc      780

gucuacgucu acaugcccaa cggcucccuc cucgaccgcc ucuccugccu cgacggcacc      840

cccccccucu ccuggcacau gcgcugcaag aucgccuga                             879


<210>  8763
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK4__Homo_sapiens__AAP57089

<400>  8763
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauuagg       60

aaacuuuccg acuucauaga uccacaggag ggguggaaga aacuggccgu ugcuaucaag      120

aaaccgucug gagacgaucg guauaaccaa uuucacauuc gccgauucga agcauuguua      180

cagacuggua agucacccac gagugagcug cuauuugacu ggggcaccac aaauuguacu      240

gccggggauc ucguggaccu gcuuauccag aacgaguucu uugcgccugc uagccuguug      300

cucccagaug ccguacccaa gaccgcaaau acacugccuu ccaaagaagc cauuaccgug      360

cagcaaaagc agaugccauu cugcgacaaa gaucguacuc ugaugacacc cguccagaac      420

cucgaacagu cuuacaugcc uccagacucg ucaagcccgg agaauaagag uuuagaggug      480

uccgauacca gauuucauuc uuucagcuuu uaugaacuga aaaacguuac gaauaacuuc      540

gacgagaggc ccaucuccgu gggaggcaau aagaugggug aagggggauu uggcgucgug      600

uacaagggcu auguaaacaa uacuaccguu gcugugaaaa aguuggcagc cauggucgau      660

auaacaacug aggagcuuaa acaacaguuc gaccaggaaa ucaaggugau ggcuaaaugu      720

cagcacgaga accuggugga acuacucggg uuuucaagug acggagauga ccugugccuu      780

gucuacguuu auaugccuaa ugguagccug uuggaucggc ucucuugucu ggacggcacc      840

ccacccuuau ccuggcauau gcgcugcaag auugccuga                             879


<210>  8764
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK4__Homo_sapiens__AAP57089

<400>  8764
augaacaagc ccaucacccc cagcaccuac gugagaugcc ugaacguggg ccugaucaga       60

aagcugagcg acuucaucga cccccaggag ggcuggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgacag auacaaccag uuccacauca gaagauucga ggcccugcug      180

cagaccggca agagccccac cagcgagcug cuguucgacu ggggcaccac caacugcacc      240

gccggcgacc ugguggaccu gcugauccag aacgaguucu ucgcccccgc cagccugcug      300

cugcccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugcccuu cugcgacaag gacagaaccc ugaugacccc cgugcagaac      420

cuggagcaga gcuacaugcc ccccgacagc agcagccccg agaacaagag ccuggaggug      480

agcgacacca gauuccacag cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagagac ccaucagcgu gggcggcaac aagaugggcg agggcggcuu cggcguggug      600

uacaagggcu acgugaacaa caccaccgug gccgugaaga agcuggccgc caugguggac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggugau ggccaagugc      720

cagcacgaga accuggugga gcugcugggc uucagcagcg acggcgacga ccugugccug      780

guguacgugu acaugcccaa cggcagccug cuggacagac ugagcugccu ggacggcacc      840

cccccccuga gcuggcacau gagaugcaag aucgccuga                             879


<210>  8765
<211>  879
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK4__Homo_sapiens__AAP57089

<400>  8765
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauucgg       60

aaacuguccg acuucaucga uccgcaggag ggguggaaga aacuugccgu ugcuauuaag      120

aaacccucug gagacgaucg cuauaaccaa uuucacauca gacgguucga agcccugcuc      180

cagacgggca agagcccuac cuccgagcug cuuuuugacu gggggacaac caauuguaca      240

gcgggagauc ugguggaccu ccugauucag aacgaguucu uugcucccgc cucucugcuc      300

cugccugaug ccgugcccaa gaccgcuaau acacuuccua gcaaagaagc caucaccguc      360

cagcaaaagc agaugccguu cugcgacaaa gaucgcacgc ugaugacccc cgugcagaac      420

cucgaacagu ccuacaugcc ucccgacucu agcuccccug agaauaagag ccuggagguu      480

ucugauacaa gauuucauuc cuucagcuuu uaugaacuua aaaacgugac caauaacuuc      540

gacgagcggc ccaucucugu cggcgggaau aagaugggag aaggcggcuu uggggugguu      600

uacaagggau augugaacaa uacaaccguc gcugugaaaa agcuggccgc gaugguggau      660

auuacgacag aggagcucaa acaacaguuc gaccaggaaa ucaaggucau ggccaaaugu      720

cagcacgaga accugguuga acugcucggc uuuuccagcg acggggauga ccugugccuu      780

guguacgugu auaugccgaa uggaucucug cucgaucgcc uguccugucu ugacggcacc      840

ccuccccuga gcuggcauau gagaugcaag auugcuuga                             879


<210>  8766
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__Q9NWZ3

<400>  8766

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu 
    290                 295                 300                 


Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser 
                325                 330                 335     


Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr 
            340                 345                 350         


Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser 
        355                 360                 365             


Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu 
    370                 375                 380                 


Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys 
385                 390                 395                 400 


Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys 
                405                 410                 415     


Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val 
            420                 425                 430         


Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys 
        435                 440                 445             


Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
    450                 455                 460 


<210>  8767
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRAK4__Homo_sapiens__AAH13316

<400>  8767
augaacaaac ccauaacacc aucaacauau gugcgcugcc ucaauguugg acuaauuagg       60

aagcugucag auuuuauuga uccucaagaa ggauggaaga aguuagcugu agcuauuaaa      120

aaaccaucug gugaugauag auacaaucag uuucacauaa ggagauuuga agcauuacuu      180

caaacuggaa aaagucccac uucugaauua cuguuugacu ggggcaccac aaauugcaca      240

guuggugauc uuguggaucu uuugauccaa aaugaauuuu uugcuccugc aagucuuuug      300

cucccagaug cuguucccaa aacugcuaau acacuaccuu cuaaagaagc uauaacaguu      360

cagcaaaaac agaugccuuu cugugacaaa gacaggacau ugaugacacc ugugcagaau      420

cuugaacaaa gcuauaugcc accugacucc ucaaguccag aaaauaaaag uuuagaaguu      480

agugauacac guuuucacag uuuuucauuu uaugaauuga agaaugucac aaauaacuuu      540

gaugaacgac ccauuucugu uggugguaau aaaaugggag agggaggauu uggaguugua      600

uauaaaggcu acguaaauaa cacaacugug gcagugaaga agcuugcagc aaugguugac      660

auuacuacug aagaacugaa acagcaguuu gaucaagaaa uaaaaguaau ggcaaagugu      720

caacaugaaa acuuaguaga acuacuuggu uucucaagug auggagauga ccucugcuua      780

guauauguuu acaugccuaa ugguucauug cuagacagac ucucuugcuu ggaugguacu      840

ccaccacuuu cuuggcacau gagaugcaag auugcucagg gugcagcuaa uggcaucaau      900

uuucuacaug aaaaucauca uauucauaga gauauuaaaa gugcaaauau cuuacuggau      960

gaagcuuuua cugcuaaaau aucugacuuu ggccuugcac gggcuucuga gaaguuugcc     1020

cagacaguca ugacuagcag aauuguggga acaacagcuu auauggcacc agaagcuuug     1080

cguggagaaa uaacacccaa aucugauauu uacagcuuug gugugguuuu acuagaaaua     1140

auaacuggac uuccagcugu ggaugaacac cgugaaccuc aguuauugcu agauauuaaa     1200

gaagaaauug aagaugaaga aaagacaauu gaagauuaua uugauaaaaa gaugaaugau     1260

gcugauucca cuucaguuga agcuauguac ucuguugcua gucaaugucu gcaugaaaag     1320

aaaaauaaga gaccagacau uaagaagguu caacagcugc ugcaagagau gacagcuucu     1380

uaa                                                                   1383


<210>  8768
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRAK4__Homo_sapiens__AAH13316

<400>  8768
augaacaagc ccaucacccc gagcaccuac gugcgcugcc ugaacgucgg ccucauccgg       60

aagcuguccg acuucaucga cccccaggag ggguggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgaccg cuacaaccag uuccacaucc ggcgcuucga ggcgcuccug      180

cagacgggga agucccccac cagcgagcuc cuguucgacu ggggcaccac caacugcacg      240

gugggggacc uggucgaccu gcucauccag aacgaguucu ucgccccggc cucccugcug      300

cuccccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc gaucaccgug      360

cagcagaagc agaugccguu cugcgacaag gaccggacgc ugaugacccc cguccagaac      420

cucgagcagu ccuacaugcc gcccgacagc uccagccccg agaacaaguc ccuggaggug      480

agcgacaccc gcuuccacuc cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagcggc ccaucuccgu cggcggcaac aagauggggg agggcggguu cggcguggug      600

uacaaggggu acgucaacaa cacgaccgug gccgugaaga agcucgccgc cauggucgac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggugau ggcgaagugc      720

cagcacgaga accuggugga gcuccugggc uucagcuccg acggcgacga ccugugccuc      780

gucuacgugu acaugcccaa cgggagccug cuggaccgcc ucuccugccu ggacggcacg      840

cccccgcuga gcuggcacau gcggugcaag aucgcccagg gggccgccaa cggcaucaac      900

uuccuccacg agaaccacca cauccaccgc gacaucaaga gcgccaacau ccugcuggac      960

gaggcguuca ccgccaagau cuccgacuuc ggccucgccc gggccagcga gaaguucgcc     1020

cagaccguga ugaccucccg caucgucggg acgaccgcgu acauggcccc cgaggcccug     1080

cggggcgaga ucacccccaa gagcgacauc uacuccuucg ggguggugcu gcucgagauc     1140

aucaccggcc ugcccgccgu cgacgagcac cgcgagccgc agcugcuccu ggacaucaag     1200

gaggagaucg aggacgagga gaagacgauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacagca ccuccgugga ggcgauguac agcgucgccu cccagugccu gcacgagaag     1320

aagaacaagc ggcccgacau caagaaggug cagcagcucc ugcaggagau gaccgccagc     1380

uga                                                                   1383


<210>  8769
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRAK4__Homo_sapiens__AAH13316

<400>  8769
augaacaagc ccaucacccc cuccaccuac guccgcugcc ucaacgucgg ccucauccgc       60

aagcucuccg acuucaucga cccccaggag ggcuggaaga agcucgccgu cgccaucaag      120

aagcccuccg gcgacgaccg cuacaaccag uuccacaucc gccgcuucga ggcccuccuc      180

cagaccggca agucccccac cuccgagcuc cucuucgacu ggggcaccac caacugcacc      240

gucggcgacc ucgucgaccu ccucauccag aacgaguucu ucgcccccgc cucccuccuc      300

cuccccgacg ccguccccaa gaccgccaac acccuccccu ccaaggaggc caucaccguc      360

cagcagaagc agaugcccuu cugcgacaag gaccgcaccc ucaugacccc cguccagaac      420

cucgagcagu ccuacaugcc ccccgacucc uccucccccg agaacaaguc ccucgagguc      480

uccgacaccc gcuuccacuc cuucuccuuc uacgagcuca agaacgucac caacaacuuc      540

gacgagcgcc ccaucuccgu cggcggcaac aagaugggcg agggcggcuu cggcgucguc      600

uacaagggcu acgucaacaa caccaccguc gccgucaaga agcucgccgc cauggucgac      660

aucaccaccg aggagcucaa gcagcaguuc gaccaggaga ucaaggucau ggccaagugc      720

cagcacgaga accucgucga gcuccucggc uucuccuccg acggcgacga ccucugccuc      780

gucuacgucu acaugcccaa cggcucccuc cucgaccgcc ucuccugccu cgacggcacc      840

cccccccucu ccuggcacau gcgcugcaag aucgcccagg gcgccgccaa cggcaucaac      900

uuccuccacg agaaccacca cauccaccgc gacaucaagu ccgccaacau ccuccucgac      960

gaggccuuca ccgccaagau cuccgacuuc ggccucgccc gcgccuccga gaaguucgcc     1020

cagaccguca ugaccucccg caucgucggc accaccgccu acauggcccc cgaggcccuc     1080

cgcggcgaga ucacccccaa guccgacauc uacuccuucg gcgucguccu ccucgagauc     1140

aucaccggcc uccccgccgu cgacgagcac cgcgagcccc agcuccuccu cgacaucaag     1200

gaggagaucg aggacgagga gaagaccauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacucca ccuccgucga ggccauguac uccgucgccu cccagugccu ccacgagaag     1320

aagaacaagc gccccgacau caagaagguc cagcagcucc uccaggagau gaccgccucc     1380

uga                                                                   1383


<210>  8770
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRAK4__Homo_sapiens__AAH13316

<400>  8770
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauuagg       60

aaacuuuccg acuucauaga uccacaggag ggguggaaga aacuggccgu ugcuaucaag      120

aaaccgucug gagacgaucg guauaaccaa uuucacauuc gccgauucga agcauuguua      180

cagacuggua agucacccac gagugagcug cuauuugacu ggggcaccac aaauuguacu      240

gugggggauc ucguagaccu gcuuauccag aacgaguucu uugccccugc gagccuguug      300

cucccagaug cugugcccaa gaccgccaau acacugccuu ccaaagaagc aauuaccguc      360

cagcaaaagc agaugccauu cugcgacaaa gaucguacuc ugaugacacc cgugcagaac      420

cucgaacagu cuuacaugcc uccagacucg ucaagcccgg agaauaagag uuuagagguu      480

uccgauacca gauuucauuc uuucagcuuu uaugaacuga aaaacgugac gaauaacuuc      540

gacgagaggc ccaucuccgu cggaggcaau aagaugggug aagggggauu uggcguggua      600

uacaagggcu auguuaacaa uacuaccgug gccgucaaaa aguuggcugc aaugguggau      660

auaacaacug aggagcuuaa acaacaguuc gaccaggaaa ucaaggugau ggccaaaugu      720

cagcacgaga accuggucga acuacucggg uuuucaagug acggagauga ccugugccuu      780

guuuacgugu auaugccuaa ugguagccug uuggaucggc ucucuugucu ggacggcacc      840

ccacccuuau ccuggcauau gcgcugcaag auugcucaag gggccgcgaa cggaaucaac      900

uuccugcacg agaaucauca cauucacaga gauaucaaau cagcaaacau acuccuugac      960

gaagccuuca cagcuaagau uagcgauuuu ggccuggcca gggcaaguga gaaguucgcu     1020

cagaccguaa ugacgucucg gaucgugggu acuacagccu acauggcgcc ugaggccuug     1080

cgcggggaaa uuaccccaaa auccgacauc uacagcuuug gagucgugcu acuggagauc     1140

auuacuggcc uccccgcagu ugaugaacau cgagagccgc agcugcuucu ggacauaaag     1200

gaagagaucg aggaugaaga gaaaacaauu gaagacuaua ucgacaagaa aaugaaugau     1260

gcugacucga ccucugugga ggccauguac uccgucgcuu cacaauguuu gcacgaaaag     1320

aagaacaaaa gaccugauau aaagaaagug cagcagcucc ugcaggagau gacggccagu     1380

uga                                                                   1383


<210>  8771
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRAK4__Homo_sapiens__AAH13316

<400>  8771
augaacaagc ccaucacccc cagcaccuac gugagaugcc ugaacguggg ccugaucaga       60

aagcugagcg acuucaucga cccccaggag ggcuggaaga agcuggccgu ggccaucaag      120

aagcccagcg gcgacgacag auacaaccag uuccacauca gaagauucga ggcccugcug      180

cagaccggca agagccccac cagcgagcug cuguucgacu ggggcaccac caacugcacc      240

gugggcgacc ugguggaccu gcugauccag aacgaguucu ucgcccccgc cagccugcug      300

cugcccgacg ccgugcccaa gaccgccaac acccugccca gcaaggaggc caucaccgug      360

cagcagaagc agaugcccuu cugcgacaag gacagaaccc ugaugacccc cgugcagaac      420

cuggagcaga gcuacaugcc ccccgacagc agcagccccg agaacaagag ccuggaggug      480

agcgacacca gauuccacag cuucagcuuc uacgagcuga agaacgugac caacaacuuc      540

gacgagagac ccaucagcgu gggcggcaac aagaugggcg agggcggcuu cggcguggug      600

uacaagggcu acgugaacaa caccaccgug gccgugaaga agcuggccgc caugguggac      660

aucaccaccg aggagcugaa gcagcaguuc gaccaggaga ucaaggugau ggccaagugc      720

cagcacgaga accuggugga gcugcugggc uucagcagcg acggcgacga ccugugccug      780

guguacgugu acaugcccaa cggcagccug cuggacagac ugagcugccu ggacggcacc      840

cccccccuga gcuggcacau gagaugcaag aucgcccagg gcgccgccaa cggcaucaac      900

uuccugcacg agaaccacca cauccacaga gacaucaaga gcgccaacau ccugcuggac      960

gaggccuuca ccgccaagau cagcgacuuc ggccuggcca gagccagcga gaaguucgcc     1020

cagaccguga ugaccagcag aaucgugggc accaccgccu acauggcccc cgaggcccug     1080

agaggcgaga ucacccccaa gagcgacauc uacagcuucg gcguggugcu gcuggagauc     1140

aucaccggcc ugcccgccgu ggacgagcac agagagcccc agcugcugcu ggacaucaag     1200

gaggagaucg aggacgagga gaagaccauc gaggacuaca ucgacaagaa gaugaacgac     1260

gccgacagca ccagcgugga ggccauguac agcguggcca gccagugccu gcacgagaag     1320

aagaacaaga gacccgacau caagaaggug cagcagcugc ugcaggagau gaccgccagc     1380

uga                                                                   1383


<210>  8772
<211>  1383
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRAK4__Homo_sapiens__AAH13316

<400>  8772
augaacaagc ccaucacccc uagcacauac gugagaugcc ugaaugucgg ccucauucgg       60

aaacuguccg acuucaucga uccgcaggag ggguggaaga aacuugccgu ugcuauuaag      120

aaacccucug gagacgaucg cuauaaccaa uuucacauca gacgguucga agcccugcuc      180

cagacgggca agagcccuac cuccgagcug cuuuuugacu gggggacaac caauuguaca      240

gugggagauc ugguggaccu ccugauucag aacgaguucu uugcgcccgc uucucugcuc      300

cugccugaug ccguccccaa gaccgccaau acacuuccua gcaaagaagc uaucaccgug      360

cagcaaaagc agaugccguu cugcgacaaa gaucgcacgc ugaugacccc cguucagaac      420

cucgaacagu ccuacaugcc ucccgacucu agcuccccug agaauaagag ccuggaggug      480

ucugauacaa gauuucauuc cuucagcuuu uaugaacuua aaaacgucac caauaacuuc      540

gacgagcggc ccaucucugu gggcgggaau aagaugggag aaggcggcuu ugggguugug      600

uacaagggau augucaacaa uacaaccgug gccgugaaaa agcuggcugc cauggucgau      660

auuacgacag aggagcucaa acaacaguuc gaccaggaaa ucaagguuau ggcgaaaugu      720

cagcacgaga accuggugga acugcucggc uuuuccagcg acggggauga ccugugccuu      780

guguacgucu auaugccgaa uggaucucug cucgaucgcc uguccugucu ugacggcacc      840

ccuccccuga gcuggcauau gagaugcaag auugcccaag gggcugccaa cggaaucaac      900

uuccuccacg agaaucauca cauucaccgg gauaucaaau ccgcuaacau ucugcuggac      960

gaagccuuca cagcgaagau cucugauuuu ggccucgccc gcgcuagcga gaaguucgcc     1020

cagaccguga ugaccuccag aaucguuggc acaacggcuu acauggcccc ugaggcccug     1080

cgcggggaaa uuacccccaa aagcgacauc uacucuuuug gagugguccu ucuggagauu     1140

aucacaggcc uccccgcugu ggaugaacau cgggagccuc agcugcuucu ggacauuaag     1200

gaagagaucg aggaugaaga gaaaaccauc gaagacuaua uugacaagaa aaugaaugau     1260

gcggacucca caagcguuga ggccauguac ucuguggcua gccaaugucu ccacgaaaag     1320

aagaacaaaa gaccggauau caagaaaguc cagcagcugc ugcaggagau gaccgccucc     1380

uga                                                                   1383


<210>  8773
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__A0A024QZE1

<400>  8773

Met Gly Thr Pro Lys Pro Arg Ile Leu Pro Trp Leu Val Ser Gln Leu 
1               5                   10                  15      


Asp Leu Gly Gln Leu Glu Gly Val Ala Trp Val Asn Lys Ser Arg Thr 
            20                  25                  30          


Arg Phe Arg Ile Pro Trp Lys His Gly Leu Arg Gln Asp Ala Gln Gln 
        35                  40                  45              


Glu Asp Phe Gly Ile Phe Gln Ala Trp Ala Glu Ala Thr Gly Ala Tyr 
    50                  55                  60                  


Val Pro Gly Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe 
65                  70                  75                  80  


Arg Ser Ala Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg 
                85                  90                  95      


Ser Lys Asp Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser 
            100                 105                 110         


Gly Val Gly Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly 
        115                 120                 125             


Gly Gly Ser Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu 
    130                 135                 140                 


Gly Asn Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu 
145                 150                 155                 160 


Ala Val Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu 
                165                 170                 175     


Asp Asn Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu 
            180                 185                 190         


Lys Arg Leu Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala 
        195                 200                 205             


Phe Tyr Arg Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu 
    210                 215                 220                 


Gly Leu Arg Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly 
225                 230                 235                 240 


Trp Pro Val Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly 
                245                 250                 255     


Val Met Ser Tyr Val Arg His Val Leu Ser Cys Leu Gly Gly Gly Leu 
            260                 265                 270         


Ala Leu Trp Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His 
        275                 280                 285             


Cys His Thr Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly 
    290                 295                 300                 


His Gly Pro Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe 
305                 310                 315                 320 


Asp Leu Gly Pro Phe Ile Val Asp Leu Ile Thr Phe Thr Glu Gly Ser 
                325                 330                 335     


Gly Arg Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp 
            340                 345                 350         


Pro Gln Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val 
        355                 360                 365             


Pro Thr Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala 
    370                 375                 380                 


Ser Ser Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro 
385                 390                 395                 400 


Leu Ser Leu Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val 
                405                 410                 415     


Glu Gly Met Asp Phe Gln Gly Pro Gly Glu Thr 
            420                 425         


<210>  8774
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__EAW52513

<400>  8774
augggaaccc caaagccacg gauccugccc uggcuggugu cgcagcugga ccuggggcaa       60

cuggagggcg uggccugggu gaacaagagc cgcacgcgcu uccgcauccc uuggaagcac      120

ggccuacggc aggaugcaca gcaggaggau uucggaaucu uccaggccug ggccgaggcc      180

acuggugcau auguucccgg gagggauaag ccagaccugc caaccuggaa gaggaauuuc      240

cgcucugccc ucaaccgcaa agaaggguug cguuuagcag aggaccggag caaggacccu      300

cacgacccac auaaaaucua cgaguuugug aacucaggag uuggggacuu uucccagcca      360

gacaccucuc cggacaccaa ugguggaggc aguacuucug auacccagga agacauucug      420

gaugaguuac uggguaacau gguguuggcc ccacucccag auccgggacc cccaagccug      480

gcuguagccc cugagcccug cccucagccc cugcggagcc ccagcuugga caaucccacu      540

cccuucccaa accuggggcc cucugagaac ccacugaagc ggcuguuggu gccgggggaa      600

gagugggagu ucgaggugac agccuucuac cggggccgcc aagucuucca gcagaccauc      660

uccugcccgg agggccugcg gcuggugggg uccgaagugg gagacaggac gcugccugga      720

uggccaguca cacugccaga cccuggcaug ucccugacag acaggggagu gaugagcuac      780

gugaggcaug ugcugagcug ccuggguggg ggacuggcuc ucuggcgggc cgggcagugg      840

cucugggccc agcggcuggg gcacugccac acauacuggg cagugagcga ggagcugcuc      900

cccaacagcg ggcaugggcc ugauggcgag guccccaagg acaaggaagg aggcguguuu      960

gaccuggggc ccuucauugu agaucugauu accuucacgg aaggaagcgg acgcucacca     1020

cgcuaugccc ucugguucug ugugggggag ucauggcccc aggaccagcc guggaccaag     1080

aggcucguga uggucaaggu ugugcccacg ugccucaggg ccuugguaga aauggcccgg     1140

guagggggug ccuccucccu ggagaauacu guggaccugc acauuuccaa cagccaccca     1200

cucucccuca ccuccgacca guacaaggcc uaccugcagg acuuggugga gggcauggau     1260

uuccagggcc cuggggagac cuga                                            1284


<210>  8775
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__EAW52513

<400>  8775
augggcaccc ccaagccgcg cauccugccc uggcucguga gccagcugga ccuggggcag       60

cucgagggcg ucgccugggu gaacaagucc cggacccgcu uccggauccc cuggaagcac      120

gggcugcgcc aggacgccca gcaggaggac uucggcaucu uccaggcgug ggccgaggcc      180

acgggggccu acgugcccgg ccgggacaag ccggaccugc ccaccuggaa gcgcaacuuc      240

cggagcgccc ucaaccgcaa ggagggccug cggcuggcgg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacagcgggg ugggcgacuu cucccagccg      360

gacaccagcc ccgacaccaa cgggggcggg uccacgagcg acacccagga ggacauccuc      420

gacgagcugc ugggcaacau ggugcucgcg ccccugcccg acccgggccc gcccucccug      480

gccgucgccc ccgagcccug cccccagccc cuccggagcc ccucccugga caacccgacc      540

cccuucccca accuggggcc cagcgagaac ccgcucaagc gccugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac cgggggcgcc aggucuucca gcagacgauc      660

uccugccccg agggccuccg gcuggugggc agcgaggugg gggaccgcac ccugcccggc      720

uggccgguca cccuccccga ccccgggaug ucccugaccg accggggcgu gaugagcuac      780

gugcgccacg uccuguccug ccucgggggc ggccuggccc uguggcgggc cgggcagugg      840

cucugggccc agcgccuggg ccacugccac acguacuggg ccgugagcga ggagcugcuc      900

ccgaacuccg ggcacggccc cgacggggag gugcccaagg acaaggaggg cggcgucuuc      960

gaccuggggc ccuucaucgu ggaccugauc accuucaccg agggcagcgg gcggagcccg     1020

cgcuacgcgc ucugguucug cgugggcgag uccuggcccc aggaccagcc cuggaccaag     1080

cgccugguca uggugaaggu gguccccacg ugccugcggg cccucgugga gauggcccgc     1140

gucgggggcg ccagcucccu ggagaacacc guggaccugc acaucagcaa cucccacccg     1200

cucagccuga ccuccgacca guacaaggcc uaccugcagg accucgugga gggcauggac     1260

uuccaggggc ccggcgagac cuga                                            1284


<210>  8776
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__EAW52513

<400>  8776
augggcaccc ccaagccccg cauccucccc uggcucgucu cccagcucga ccucggccag       60

cucgagggcg ucgccugggu caacaagucc cgcacccgcu uccgcauccc cuggaagcac      120

ggccuccgcc aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acguccccgg ccgcgacaag cccgaccucc ccaccuggaa gcgcaacuuc      240

cgcuccgccc ucaaccgcaa ggagggccuc cgccucgccg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacuccggcg ucggcgacuu cucccagccc      360

gacaccuccc ccgacaccaa cggcggcggc uccaccuccg acacccagga ggacauccuc      420

gacgagcucc ucggcaacau gguccucgcc ccccuccccg accccggccc ccccucccuc      480

gccgucgccc ccgagcccug cccccagccc cuccgcuccc ccucccucga caaccccacc      540

cccuucccca accucggccc cuccgagaac ccccucaagc gccuccucgu ccccggcgag      600

gagugggagu ucgaggucac cgccuucuac cgcggccgcc aggucuucca gcagaccauc      660

uccugccccg agggccuccg ccucgucggc uccgaggucg gcgaccgcac ccuccccggc      720

uggcccguca cccuccccga ccccggcaug ucccucaccg accgcggcgu cauguccuac      780

guccgccacg uccucuccug ccucggcggc ggccucgccc ucuggcgcgc cggccagugg      840

cucugggccc agcgccucgg ccacugccac accuacuggg ccgucuccga ggagcuccuc      900

cccaacuccg gccacggccc cgacggcgag guccccaagg acaaggaggg cggcgucuuc      960

gaccucggcc ccuucaucgu cgaccucauc accuucaccg agggcuccgg ccgcuccccc     1020

cgcuacgccc ucugguucug cgucggcgag uccuggcccc aggaccagcc cuggaccaag     1080

cgccucguca uggucaaggu cguccccacc ugccuccgcg cccucgucga gauggcccgc     1140

gucggcggcg ccuccucccu cgagaacacc gucgaccucc acaucuccaa cucccacccc     1200

cucucccuca ccuccgacca guacaaggcc uaccuccagg accucgucga gggcauggac     1260

uuccagggcc ccggcgagac cuga                                            1284


<210>  8777
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__EAW52513

<400>  8777
augggcaccc ccaagccuag aauccugcca uggcucguga gccagcuuga ccuggggcaa       60

uuggagggag ucgccugggu uaacaaaucc aggacacggu uccgcauucc guggaagcac      120

gguuuacgac aggaugcuca gcaggaagac uuuggcauau uccaagcaug ggccgaggcg      180

acuggggcuu acgugcccgg acgugauaaa ccugaccugc caacguggaa gagaaauuuu      240

aggucugccc uaaaccggaa agaaggccuc cgccuggcag aggauagauc aaaggacccc      300

caugauccuc acaagaucua ugaguucgua aauaguggug ugggggacuu uagccagcca      360

gauaccuccc ccgacacaaa cggaggcggc ucuacuucgg auacccagga agacauucuu      420

gaugagcugu uggggaauau gguccucgcc ccucugccag acccgggacc cccuucacug      480

gcuguggcac cagaacccug cccucagcca cucaggagcc ccaguuuaga caacccgaca      540

ccuuucccca aucugggucc auccgagaac ccucuuaaac gguugcuggu ucccggcgaa      600

gagugggagu uugaagugac cgccuucuac cgcgggcgac aagucuuuca gcagacuauc      660

ucuuguccag agggacuaag acucgugggc agcgaaguag gugauaggac acugcccggg      720

uggccuguua cccuuccaga cccgggaaug ucccugacgg aucggggcgu gaugucauau      780

guccgucaug uguugaguug ccucggcggg ggacuggcuu uauggcgcgc cggucagugg      840

cugugggcgc aaagacucgg ccacugucau acuuacuggg cagugagcga ggaacuucug      900

cccaauucug ggcacggacc ugacggcgag gucccaaagg auaaagaggg ugggguuuuc      960

gacuugggcc ccuuuauugu ggaucuaauc accuucacag aaggauccgg caggucaccu     1020

cgguaugccc ugugguuuug cguaggggag agcuggccac aggaccagcc cuggacuaag     1080

cgacucguga uggucaaagu gguuccgacc ugucugcgcg cucuugugga aauggccaga     1140

gucggaggug caaguucucu ggagaacaca guggauuugc acauauccaa uagccauccu     1200

cucucgcuga ccucugacca auacaaggcu uauuuacagg aucugguaga aggcauggac     1260

uuccaggggc caggagagac guga                                            1284


<210>  8778
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__EAW52513

<400>  8778
augggcaccc ccaagcccag aauccugccc uggcugguga gccagcugga ccugggccag       60

cuggagggcg uggccugggu gaacaagagc agaaccagau ucagaauccc cuggaagcac      120

ggccugagac aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acgugcccgg cagagacaag cccgaccugc ccaccuggaa gagaaacuuc      240

agaagcgccc ugaacagaaa ggagggccug agacuggccg aggacagaag caaggacccc      300

cacgaccccc acaagaucua cgaguucgug aacagcggcg ugggcgacuu cagccagccc      360

gacaccagcc ccgacaccaa cggcggcggc agcaccagcg acacccagga ggacauccug      420

gacgagcugc ugggcaacau ggugcuggcc ccccugcccg accccggccc ccccagccug      480

gccguggccc ccgagcccug cccccagccc cugagaagcc ccagccugga caaccccacc      540

cccuucccca accugggccc cagcgagaac ccccugaaga gacugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac agaggcagac agguguucca gcagaccauc      660

agcugccccg agggccugag acuggugggc agcgaggugg gcgacagaac ccugcccggc      720

uggcccguga cccugcccga ccccggcaug agccugaccg acagaggcgu gaugagcuac      780

gugagacacg ugcugagcug ccugggcggc ggccuggccc uguggagagc cggccagugg      840

cugugggccc agagacuggg ccacugccac accuacuggg ccgugagcga ggagcugcug      900

cccaacagcg gccacggccc cgacggcgag gugcccaagg acaaggaggg cggcguguuc      960

gaccugggcc ccuucaucgu ggaccugauc accuucaccg agggcagcgg cagaagcccc     1020

agauacgccc ugugguucug cgugggcgag agcuggcccc aggaccagcc cuggaccaag     1080

agacugguga uggugaaggu ggugcccacc ugccugagag cccuggugga gauggccaga     1140

gugggcggcg ccagcagccu ggagaacacc guggaccugc acaucagcaa cagccacccc     1200

cugagccuga ccagcgacca guacaaggcc uaccugcagg accuggugga gggcauggac     1260

uuccagggcc ccggcgagac cuga                                            1284


<210>  8779
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__EAW52513

<400>  8779
augggcaccc ccaagccuag aauccugccg uggcucguga gccagcugga ccuugggcaa       60

cuggagggag ucgccugggu uaacaaaucc cggacacgcu uccggauucc cuggaagcac      120

ggccucagac aggaugcuca gcaggaagac uuugggaucu uccaagccug ggcggaggcu      180

acgggagccu acgugccugg ccgcgauaaa cccgaccugc cuaccuggaa gagaaauuuu      240

cggucugccc uuaaccgcaa agaagggcug agacucgcug aggaucggag caaggacccc      300

caugauccuc acaagauuua ugaguucguc aauuccggag ugggcgacuu uucucagccg      360

gauacaagcc ccgacaccaa cggcggggga uccacaucug auacccagga agacauccug      420

gaugagcugc ucggcaauau ggugcuggcc ccucuucccg acccugggcc cccgagccug      480

gcuguugccc cugaacccug cccucagccc cuccgcuccc ccagccugga caacccuaca      540

ccguucccca aucuuggacc uucugagaac ccccugaaaa gacuccuggu gccuggcgaa      600

gagugggagu uugaagucac cgcguucuac cgggggcgcc aaguguuuca gcagacgauu      660

uccugucccg agggacugag acucguuggc agcgaagugg gcgaucggac ccugccgggg      720

uggccuguca cacuucccga cccuggaaug ucucugaccg aucgcggcgu gauguccuau      780

gugagacaug uccucagcug ccuuggggga ggccuggccc uguggcgggc ugggcagugg      840

cucugggccc aaagacuggg acacugucau acauacuggg cuguuucuga ggaacugcuc      900

cccaauuccg gccacggccc ugacggggag gugcccaagg auaaagaggg aggcguguuc      960

gaccuggggc cguuuaucgu cgaucuuauc accuucacgg aaggaagcgg ccgcuccccu     1020

cgguaugccc ugugguuuug cgugggggag ucuuggcccc aggaccagcc cuggacaaag     1080

agacucguua uggugaaagu cgugccuacc ugucugcgcg cgcuuguuga aauggcccgg     1140

gugggcggag cuagcucccu ggagaacaca gucgaucucc acauuagcaa uucucauccg     1200

cugucccuga ccagcgacca auacaaggcc uaucuccagg aucuggugga aggcauggac     1260

uuccaggggc ccggagagac cuga                                            1284


<210>  8780
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__E2GIM5

<400>  8780

Met Val Gly Arg Lys Gln Gly Trp Ser Cys Arg Leu Thr Gly Ile Lys 
1               5                   10                  15      


Pro Gly Lys Pro Ala Trp Ala Glu Ala Thr Gly Ala Tyr Val Pro Gly 
            20                  25                  30          


Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe Arg Ser Ala 
        35                  40                  45              


Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg Ser Lys Asp 
    50                  55                  60                  


Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser Gly Val Gly 
65                  70                  75                  80  


Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly Gly Gly Ser 
                85                  90                  95      


Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu Gly Asn Met 
            100                 105                 110         


Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu Ala Val Ala 
        115                 120                 125             


Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu Asp Asn Pro 
    130                 135                 140                 


Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu Lys Arg Leu 
145                 150                 155                 160 


Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala Phe Tyr Arg 
                165                 170                 175     


Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu Gly Leu Arg 
            180                 185                 190         


Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly Trp Pro Val 
        195                 200                 205             


Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly Val Met Ser 
    210                 215                 220                 


Tyr Val Arg His Val Pro Ser Cys Leu Gly Gly Gly Leu Ala Leu Trp 
225                 230                 235                 240 


Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His Cys His Thr 
                245                 250                 255     


Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly His Gly Pro 
            260                 265                 270         


Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe Asp Leu Gly 
        275                 280                 285             


Pro Phe Ile Val Asp Leu Ile Thr Phe Thr Glu Gly Ser Gly Arg Ser 
    290                 295                 300                 


Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp Pro Gln Asp 
305                 310                 315                 320 


Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val Pro Thr Cys 
                325                 330                 335     


Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala Ser Ser Leu 
            340                 345                 350         


Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro Leu Ser Leu 
        355                 360                 365             


Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val Glu Gly Met 
    370                 375                 380                 


Asp Phe Gln Gly Pro Gly Glu Thr 
385                 390         


<210>  8781
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__ADN86147

<400>  8781
augguggggc gcaagcaggg uuggagcugc aggcuuacgg gaauaaaacc gggaaagccg       60

gccugggccg aggccacugg ugcauauguu cccgggaggg auaagccaga ccugccaacc      120

uggaagagga auuuccgcuc ugcccucaac cgcaaagaag gguugcguuu agcagaggac      180

cggagcaagg acccucacga cccacauaaa aucuacgagu uugugaacuc aggaguuggg      240

gacuuuuccc agccagacac cucuccggac accaauggug gaggcaguac uucugauacc      300

caggaagaca uucuggauga guuacugggu aacauggugu uggccccacu cccagauccg      360

ggacccccaa gccuggcugu agccccugag cccugcccuc agccccugcg gagccccagc      420

uuggacaauc ccacucccuu cccaaaccug gggcccucug agaacccacu gaagcggcug      480

uuggugccgg gggaagagug ggaguucgag gugacagccu ucuaccgggg ccgccaaguc      540

uuccagcaga ccaucuccug cccggagggc cugcggcugg ugggguccga agugggagac      600

aggacgcugc cuggauggcc agucacacug ccagacccug gcaugucccu gacagacagg      660

ggagugauga gcuacgugag gcaugugccg agcugccugg gugggggacu ggcucucugg      720

cgggccgggc aguggcucug ggcccagcgg cuggggcacu gccacacaua cugggcagug      780

agcgaggagc ugcuccccaa cagcgggcau gggccugaug gcgagguccc caaggacaag      840

gaaggaggcg uguuugaccu ggggcccuuc auuguagauc ugauuaccuu cacggaagga      900

agcggacgcu caccacgcua ugcccucugg uucugugugg gggagucaug gccccaggac      960

cagccgugga ccaagaggcu cgugaugguc aagguugugc ccacgugccu cagggccuug     1020

guagaaaugg cccggguagg gggugccucc ucccuggaga auacugugga ccugcacauu     1080

uccaacagcc acccacucuc ccucaccucc gaccaguaca aggccuaccu gcaggacuug     1140

guggagggca uggauuucca gggcccuggg gagaccuga                            1179


<210>  8782
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__ADN86147

<400>  8782
auggugggcc gcaagcaggg guggagcugc cggcugaccg gcaucaagcc cgggaagccg       60

gccugggccg aggcgaccgg cgccuacguc cccgggcgcg acaagcccga ccuccccacg      120

uggaagcgga acuuccgcuc cgcccugaac cggaaggagg gccugcgccu cgccgaggac      180

cggagcaagg acccgcacga cccccacaag aucuacgagu ucgugaacuc cggcgugggg      240

gacuucagcc agcccgacac cucccccgac accaacggcg ggggcagcac cuccgacacg      300

caggaggaca uccuggacga gcugcucggg aacauggucc uggccccgcu gcccgacccc      360

gggcccccga gccucgcggu ggcccccgag cccugccccc agccgcugcg cucccccagc      420

cuggacaacc ccacccccuu cccgaaccuc ggccccuccg agaacccccu gaagcggcug      480

cucgugcccg gggaggagug ggaguucgag gucaccgccu ucuaccgcgg ccgccaggug      540

uuccagcaga ccaucagcug cccggagggg cugcggcugg ugggcuccga ggucggcgac      600

cggacgcucc ccggguggcc cgugacccug cccgacccgg gcaugagccu gaccgaccgc      660

ggggugaugu ccuacguccg gcacgugccc agcugccucg gcgggggccu ggcccugugg      720

cgcgcgggcc aguggcucug ggcccagcgg cuggggcacu gccacaccua cugggccgug      780

uccgaggagc ugcuccccaa cagcggccac gggccggacg gcgagguccc caaggacaag      840

gagggcggcg uguucgaccu gggccccuuc aucguggacc ugaucacguu caccgagggg      900

uccggccgca gcccccggua cgcccucugg uucugcgucg gggagagcug gccgcaggac      960

cagcccugga ccaagcgccu ggugauggug aaggucgugc cgaccugccu gcgggcccuc     1020

guggagaugg cgcgcgucgg cggggccucc agccuggaga acacggugga ccugcacauc     1080

uccaacagcc acccccucuc ccugaccagc gaccaguaca aggccuaccu gcaggaccuc     1140

gucgagggca uggacuucca gggccccggg gagaccuga                            1179


<210>  8783
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__ADN86147

<400>  8783
auggucggcc gcaagcaggg cugguccugc cgccucaccg gcaucaagcc cggcaagccc       60

gccugggccg aggccaccgg cgccuacguc cccggccgcg acaagcccga ccuccccacc      120

uggaagcgca acuuccgcuc cgcccucaac cgcaaggagg gccuccgccu cgccgaggac      180

cgcuccaagg acccccacga cccccacaag aucuacgagu ucgucaacuc cggcgucggc      240

gacuucuccc agcccgacac cucccccgac accaacggcg gcggcuccac cuccgacacc      300

caggaggaca uccucgacga gcuccucggc aacauggucc ucgccccccu ccccgacccc      360

ggcccccccu cccucgccgu cgcccccgag cccugccccc agccccuccg cucccccucc      420

cucgacaacc ccacccccuu ccccaaccuc ggccccuccg agaacccccu caagcgccuc      480

cucguccccg gcgaggagug ggaguucgag gucaccgccu ucuaccgcgg ccgccagguc      540

uuccagcaga ccaucuccug ccccgagggc cuccgccucg ucggcuccga ggucggcgac      600

cgcacccucc ccggcuggcc cgucacccuc cccgaccccg gcaugucccu caccgaccgc      660

ggcgucaugu ccuacguccg ccacgucccc uccugccucg gcggcggccu cgcccucugg      720

cgcgccggcc aguggcucug ggcccagcgc cucggccacu gccacaccua cugggccguc      780

uccgaggagc uccuccccaa cuccggccac ggccccgacg gcgagguccc caaggacaag      840

gagggcggcg ucuucgaccu cggccccuuc aucgucgacc ucaucaccuu caccgagggc      900

uccggccgcu ccccccgcua cgcccucugg uucugcgucg gcgaguccug gccccaggac      960

cagcccugga ccaagcgccu cgucaugguc aaggucgucc ccaccugccu ccgcgcccuc     1020

gucgagaugg cccgcgucgg cggcgccucc ucccucgaga acaccgucga ccuccacauc     1080

uccaacuccc acccccucuc ccucaccucc gaccaguaca aggccuaccu ccaggaccuc     1140

gucgagggca uggacuucca gggccccggc gagaccuga                            1179


<210>  8784
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__ADN86147

<400>  8784
auggugggca gaaagcaggg guggagcugc aggcugaccg gaaucaaacc cgguaagccu       60

gccugggcug aggcaacagg cgccuacguc ccagggcggg acaaaccgga ucuccccacu      120

uggaagcgca acuuccgauc cgcgcuuaau cguaaagaag gacugagauu ggcugaggac      180

aggucuaagg auccucacga cccacauaag auuuaugaau uuguuaacuc aggcgugggu      240

gauuucaguc aacccgacac gagcccugau accaaugggg gaggcuccac aucugacacu      300

caggaggaua uauuagacga acugcuaggc aacaugguac ucgccccacu gcccgauccu      360

gggccaccgu cgcuugcagu ggcccccgag ccuuguccac agccccugcg gucaccuagc      420

uuggacaauc caacccccuu uccgaaccuc ggaccuagug agaauccccu gaaacgccug      480

cucgucccag gugaagagug ggaguucgaa gugacagcuu uuuacagagg caggcagguu      540

uuccaacaga ccaucuccug cccugagggg uuacggcugg ugggaucuga agucggcgau      600

cgcacucuuc ccgguuggcc agugacauug cccgacccug ggaugagccu gaccgaccga      660

ggaguaaugu ccuauguuag acacgugcca ucaugucuag gcggcgggcu cgcacugugg      720

agggccggac aguggcuuug ggcucagcgg cugggucauu gccacacgua cugggccguc      780

agugaggaau ugcucccgaa cagcggccau gggcccgaug gagaggugcc uaaggacaaa      840

gaaggcggug uguuugaucu ggggccauuc auugucgacu uaaucacuuu uaccgagggc      900

ucuggacguu caccccgcua ugcgcugugg uucuguguug gcgaguccug gccucaagau      960

cagccaugga caaagagacu cgugauggua aaaguggucc ccacuugccu uagggcacug     1020

guggaaaugg cccggguugg gggagcuagc aguuuggaga auaccgugga ccuacacauu     1080

ucuaacuccc acccgcugag ccucacaucg gaucaguaca aggccuaucu gcaggaccuu     1140

gucgaaggua uggauuuuca aggcccuggg gagaccuga                            1179


<210>  8785
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__ADN86147

<400>  8785
auggugggca gaaagcaggg cuggagcugc agacugaccg gcaucaagcc cggcaagccc       60

gccugggccg aggccaccgg cgccuacgug cccggcagag acaagcccga ccugcccacc      120

uggaagagaa acuucagaag cgcccugaac agaaaggagg gccugagacu ggccgaggac      180

agaagcaagg acccccacga cccccacaag aucuacgagu ucgugaacag cggcgugggc      240

gacuucagcc agcccgacac cagccccgac accaacggcg gcggcagcac cagcgacacc      300

caggaggaca uccuggacga gcugcugggc aacauggugc uggccccccu gcccgacccc      360

ggccccccca gccuggccgu ggcccccgag cccugccccc agccccugag aagccccagc      420

cuggacaacc ccacccccuu ccccaaccug ggccccagcg agaacccccu gaagagacug      480

cuggugcccg gcgaggagug ggaguucgag gugaccgccu ucuacagagg cagacaggug      540

uuccagcaga ccaucagcug ccccgagggc cugagacugg ugggcagcga ggugggcgac      600

agaacccugc ccggcuggcc cgugacccug cccgaccccg gcaugagccu gaccgacaga      660

ggcgugauga gcuacgugag acacgugccc agcugccugg gcggcggccu ggcccugugg      720

agagccggcc aguggcugug ggcccagaga cugggccacu gccacaccua cugggccgug      780

agcgaggagc ugcugcccaa cagcggccac ggccccgacg gcgaggugcc caaggacaag      840

gagggcggcg uguucgaccu gggccccuuc aucguggacc ugaucaccuu caccgagggc      900

agcggcagaa gccccagaua cgcccugugg uucugcgugg gcgagagcug gccccaggac      960

cagcccugga ccaagagacu ggugauggug aagguggugc ccaccugccu gagagcccug     1020

guggagaugg ccagaguggg cggcgccagc agccuggaga acaccgugga ccugcacauc     1080

agcaacagcc acccccugag ccugaccagc gaccaguaca aggccuaccu gcaggaccug     1140

guggagggca uggacuucca gggccccggc gagaccuga                            1179


<210>  8786
<211>  1179
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__ADN86147

<400>  8786
auggugggca gaaagcaggg guggagcugc cggcugaccg gaaucaaacc cggcaagccu       60

gccugggcug aggccacagg ggcguacguc ccgggacgcg acaaacccga ucucccuacg      120

uggaagagaa acuuccgguc cgcucugaau cgcaaagaag gccuuagacu ggccgaggac      180

cggucuaagg auccccacga cccucauaag auuuaugaau uuguuaacag cgggguggga      240

gauuucuccc aacccgacac cucuccugau acaaauggcg gcgggagcac cuccgacaca      300

caggaggaua uccucgacga acugcuugga aacauggugc uggccccgcu ccccgauccu      360

gggcccccuu cucuggcugu cgcccccgag ccguguccuc agccccugcg cagcccuucc      420

cucgacaauc ccacccccuu uccuaaccug gggccgagcg agaauccccu uaaaagacug      480

cucgugccug gagaagagug ggaguucgaa guuacagcuu uuuaccgggg ccgccaggug      540

uuccaacaga ccauuucuug ccccgagggg cugagacuug ucggauccga agugggcgau      600

cggacgcugc cuggcuggcc cguuacccuc ccggacccug ggaugagccu gacagaccgc      660

ggagugaugu cuuaugucag acacgugccc uccugucugg gcgggggacu cgcccugugg      720

cgggcgggcc aguggcuuug ggcccagcgc cuggggcauu gccacaccua cugggcugug      780

agcgaggaac uccugccuaa cucuggacau ggccccgaug gcgagguccc uaaggacaaa      840

gaagggggag uuuuugaucu uggccccuuc aucguggacc ugauuacauu uaccgagggg      900

uccggaagaa gcccgcggua ugcccucugg uucugugugg gcgaguccug gccucaagau      960

cagcccugga cgaagagacu ggucauggug aaaguugugc ccacaugccu gcgcgcucuc     1020

gucgaaaugg cccggguggg cggcgcgucu agccuggaga auaccguuga ccuucacauc     1080

uccaacagcc acccucuguc ucucacaucc gaucaguaca aggccuaucu gcaggaccuu     1140

guggaaggaa uggauuuuca aggcccgggg gagaccuga                            1179


<210>  8787
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__E2GIM6

<400>  8787

Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu Ala Val 
1               5                   10                  15      


Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu Asp Asn 
            20                  25                  30          


Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu Lys Arg 
        35                  40                  45              


Leu Leu Val Pro Gly Glu Asp Leu Ile Thr Phe Thr Glu Gly Ser Gly 
    50                  55                  60                  


Arg Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp Pro 
65                  70                  75                  80  


Gln Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val Pro 
                85                  90                  95      


Thr Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala Ser 
            100                 105                 110         


Ser Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro Leu 
        115                 120                 125             


Ser Leu Thr Ser Asp Gln His Lys Ala Tyr Leu Gln Asp Leu Val Glu 
    130                 135                 140                 


Gly Met Asp Phe Gln Gly Pro Gly Glu Thr 
145                 150                 


<210>  8788
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__ADN86148

<400>  8788
augguguugg ccccacuccc agauccggga cccccaagcc uggcuguagc cccugagccc       60

ugcccucagc cccugcggag ccccagcuug gacaauccca cucccuuccc aaaccugggg      120

cccucugaga acccacugaa gcggcuguug gugccggggg aagaucugau uaccuucacg      180

gaaggaagcg gacgcucacc acgcuaugcc cucugguucu guguggggga gucauggccc      240

caggaccagc cguggaccaa gaggcucgug auggucaagg uugugcccac gugccucagg      300

gccuugguag aaauggcccg gguagggggu gccuccuccc uggagaauac uguggaccug      360

cacauuucca acagccaccc acucucccuc accuccgacc agcacaaggc cuaccugcag      420

gacuuggugg agggcaugga uuuccagggc ccuggggaga ccuga                      465


<210>  8789
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__ADN86148

<400>  8789
auggugcugg cgccccuccc ggaccccggc ccgcccagcc uggccgucgc ccccgagccc       60

ugcccccagc cccugcgcuc cccgagccuc gacaacccca cccccuuccc caaccugggg      120

ccguccgaga acccccugaa gcggcuccug gugcccggcg aggaccugau caccuucacg      180

gaggggagcg gccgcagccc ccgguacgcc cucugguucu gcguggggga guccuggccg      240

caggaccagc ccuggaccaa gcgccugguc auggugaagg uggucccgac cugccugcgg      300

gcccucgugg agauggcccg cgugggcggc gccuccagcc uggagaacac cgucgaccug      360

cacaucucca acagccaccc ccucucccug acgagcgacc agcacaaggc guaccugcag      420

gaccucgugg aggggaugga cuuccagggc cccggggaga ccuga                      465


<210>  8790
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__ADN86148

<400>  8790
augguccucg ccccccuccc cgaccccggc ccccccuccc ucgccgucgc ccccgagccc       60

ugcccccagc cccuccgcuc ccccucccuc gacaacccca cccccuuccc caaccucggc      120

cccuccgaga acccccucaa gcgccuccuc guccccggcg aggaccucau caccuucacc      180

gagggcuccg gccgcucccc ccgcuacgcc cucugguucu gcgucggcga guccuggccc      240

caggaccagc ccuggaccaa gcgccucguc auggucaagg ucguccccac cugccuccgc      300

gcccucgucg agauggcccg cgucggcggc gccuccuccc ucgagaacac cgucgaccuc      360

cacaucucca acucccaccc ccucucccuc accuccgacc agcacaaggc cuaccuccag      420

gaccucgucg agggcaugga cuuccagggc cccggcgaga ccuga                      465


<210>  8791
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__ADN86148

<400>  8791
auggugcugg cuccccuccc ugacccaggc ccgcccagcc uugccgucgc accugagcca       60

ugcccccagc cucugagauc cccaucuuug gauaacccca ccccuuuccc aaauuuaggg      120

ccgucagaaa acccccugaa gaggcuacuc guuccuggag aggaccugau cacauuuacu      180

gaagguagug gccggagccc acgcuacgcc cuuugguucu guguggggga guccuggccc      240

caagaucagc cuuggacgaa acgacuggua auggugaagg ucgugccaac cugcuugcgu      300

gcgcucguug aaauggcuag agugggaggc gccucuucgc uggagaauac agucgaccug      360

cacauuucaa acagccaucc ccucaguuua acuuccgauc agcacaaagc auaucugcag      420

gaccuugugg aggguaugga uuuucaaggg ccgggagaaa ccuga                      465


<210>  8792
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__ADN86148

<400>  8792
auggugcugg ccccccugcc cgaccccggc ccccccagcc uggccguggc ccccgagccc       60

ugcccccagc cccugagaag ccccagccug gacaacccca cccccuuccc caaccugggc      120

cccagcgaga acccccugaa gagacugcug gugcccggcg aggaccugau caccuucacc      180

gagggcagcg gcagaagccc cagauacgcc cugugguucu gcgugggcga gagcuggccc      240

caggaccagc ccuggaccaa gagacuggug auggugaagg uggugcccac cugccugaga      300

gcccuggugg agauggccag agugggcggc gccagcagcc uggagaacac cguggaccug      360

cacaucagca acagccaccc ccugagccug accagcgacc agcacaaggc cuaccugcag      420

gaccuggugg agggcaugga cuuccagggc cccggcgaga ccuga                      465


<210>  8793
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__ADN86148

<400>  8793
auggugcugg cuccccuccc ugacccgggg cccccuagcc uggcugucgc ccccgagccu       60

ugcccccagc cucuuagauc cccgucucug gauaacccca ccccuuuccc caaucucggc      120

ccuagcgaaa acccccugaa gcggcuucug guuccgggag aggaccucau cacauuuacg      180

gaaggcuccg ggcgcucucc uagauacgcg cugugguucu gugugggaga gagcuggccc      240

caagaucagc cuuggaccaa acggcuggug auggucaagg ugguucccac augccuccgc      300

gcucuggugg aaauggccag agucggcggg gccuccucuc uugagaauac cguggaccug      360

cacauuagca acucccaucc ccucagccug acaucugauc agcacaaagc cuaucuucag      420

gaccugguug agggaaugga uuuucaaggc ccuggcgaaa ccuga                      465


<210>  8794
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__E2GIM7

<400>  8794

Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu Ala Val 
1               5                   10                  15      


Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu Asp Asn 
            20                  25                  30          


Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu Lys Arg 
        35                  40                  45              


Leu Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala Phe Tyr 
    50                  55                  60                  


Arg Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu Gly Leu 
65                  70                  75                  80  


Arg Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly Trp Pro 
                85                  90                  95      


Val Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly Val Met 
            100                 105                 110         


Ser Tyr Val Arg His Val Leu Ser Cys Leu Gly Gly Gly Leu Ala Leu 
        115                 120                 125             


Trp Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His Cys His 
    130                 135                 140                 


Thr Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly His Gly 
145                 150                 155                 160 


Pro Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe Asp Leu 
                165                 170                 175     


Gly Pro Phe Ile Val Asp Leu Ile Thr Phe Thr Glu Gly Ser Gly Arg 
            180                 185                 190         


Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp Pro Gln 
        195                 200                 205             


Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val Pro Thr 
    210                 215                 220                 


Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala Ser Ser 
225                 230                 235                 240 


Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro Leu Ser 
                245                 250                 255     


Leu Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val Glu Gly 
            260                 265                 270         


Met Asp Phe Gln Gly Pro Gly Glu Thr 
        275                 280     


<210>  8795
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__ADN86149

<400>  8795
augguguugg ccccacuccc agauccggga cccccaagcc uggcuguagc cccugagccc       60

ugcccucagc cccugcggag ccccagcuug gacaauccca cucccuuccc aaaccugggg      120

cccucugaga acccacugaa gcggcuguug gugccggggg aagaguggga guucgaggug      180

acagccuucu accggggccg ccaagucuuc cagcagacca ucuccugccc ggagggccug      240

cggcuggugg gguccgaagu gggagacagg acgcugccug gauggccagu cacacugcca      300

gacccuggca ugucccugac agacagggga gugaugagcu acgugaggca ugugcugagc      360

ugccugggug ggggacuggc ucucuggcgg gccgggcagu ggcucugggc ccagcggcug      420

gggcacugcc acacauacug ggcagugagc gaggagcugc uccccaacag cgggcauggg      480

ccugauggcg agguccccaa ggacaaggaa ggaggcgugu uugaccuggg gcccuucauu      540

guagaucuga uuaccuucac ggaaggaagc ggacgcucac cacgcuaugc ccucugguuc      600

uguguggggg agucauggcc ccaggaccag ccguggacca agaggcucgu gauggucaag      660

guugugccca cgugccucag ggccuuggua gaaauggccc ggguaggggg ugccuccucc      720

cuggagaaua cuguggaccu gcacauuucc aacagccacc cacucucccu caccuccgac      780

caguacaagg ccuaccugca ggacuuggug gagggcaugg auuuccaggg cccuggggag      840

accuga                                                                 846


<210>  8796
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__ADN86149

<400>  8796
auggugcugg cgccccuccc ggaccccggc ccgcccagcc uggccgucgc ccccgagccc       60

ugcccccagc cccugcgcuc cccgagccuc gacaacccca cccccuuccc caaccugggg      120

ccguccgaga acccccugaa gcggcuccug gugcccggcg aggaguggga guucgaggug      180

accgccuucu accgcgggcg gcaggucuuc cagcagacga ucagcugccc cgagggccug      240

cgccucgugg gguccgaggu gggcgaccgg acccugccgg gcuggcccgu cacccugccc      300

gaccccggga ugagccucac cgaccgcggc gugauguccu acgugcggca cguccugagc      360

ugccucgggg gcgggcuggc ccuguggcgc gccggccagu ggcugugggc ccagcggcuc      420

ggccacugcc acacguacug ggcggugucc gaggagcugc ugccgaacag cgggcacggc      480

cccgacgggg aggugcccaa ggacaaggag ggcggcgucu ucgaccucgg gcccuucauc      540

guggaccuga ucaccuucac cgagggcucc gggcgcagcc cgcgguacgc ccugugguuc      600

ugcgugggcg aguccuggcc ccaggaccag cccuggacca agcgccucgu cauggugaag      660

guggucccca cgugccugcg ggcccuggug gagauggccc gcgucggggg cgcgagcucc      720

cucgagaaca ccguggaccu gcacaucagc aacucccacc cgcugagccu caccuccgac      780

caguacaagg ccuaccugca ggaccuggug gagggcaugg acuuccaggg gcccggcgag      840

accuga                                                                 846


<210>  8797
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__ADN86149

<400>  8797
augguccucg ccccccuccc cgaccccggc ccccccuccc ucgccgucgc ccccgagccc       60

ugcccccagc cccuccgcuc ccccucccuc gacaacccca cccccuuccc caaccucggc      120

cccuccgaga acccccucaa gcgccuccuc guccccggcg aggaguggga guucgagguc      180

accgccuucu accgcggccg ccaggucuuc cagcagacca ucuccugccc cgagggccuc      240

cgccucgucg gcuccgaggu cggcgaccgc acccuccccg gcuggcccgu cacccucccc      300

gaccccggca ugucccucac cgaccgcggc gucauguccu acguccgcca cguccucucc      360

ugccucggcg gcggccucgc ccucuggcgc gccggccagu ggcucugggc ccagcgccuc      420

ggccacugcc acaccuacug ggccgucucc gaggagcucc uccccaacuc cggccacggc      480

cccgacggcg agguccccaa ggacaaggag ggcggcgucu ucgaccucgg ccccuucauc      540

gucgaccuca ucaccuucac cgagggcucc ggccgcuccc cccgcuacgc ccucugguuc      600

ugcgucggcg aguccuggcc ccaggaccag cccuggacca agcgccucgu cauggucaag      660

gucgucccca ccugccuccg cgcccucguc gagauggccc gcgucggcgg cgccuccucc      720

cucgagaaca ccgucgaccu ccacaucucc aacucccacc cccucucccu caccuccgac      780

caguacaagg ccuaccucca ggaccucguc gagggcaugg acuuccaggg ccccggcgag      840

accuga                                                                 846


<210>  8798
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__ADN86149

<400>  8798
auggugcugg cuccccuccc ugacccaggc ccgcccagcc uugcugucgc accugagcca       60

ugcccccagc cucugagauc cccaucuuug gauaacccca ccccuuuccc aaauuuaggg      120

ccgucagaaa acccccugaa gaggcuacuc guuccuggag aggaauggga guuugaagug      180

acagccuucu accggggucg ccaaguauuu cagcagacua ucaguugucc agagggccug      240

cgacuugugg ggagcgaggu cggagaccgu acgcugcccg gcuggccugu gaccuugcca      300

gaucccggua ugucccucac agacagaggg guuaugucuu augugaggca cguccugucg      360

ugccugggag gcggccucgc guuauggcgg gcugggcagu ggcugugggc ccaacgccuu      420

ggacauuguc acacuuacug ggcaguguca gaagaguugc ugccgaauag cggucauggc      480

ccugaugggg aaguacccaa agacaaggag ggaggcguuu ucgaucuagg uccauuuauu      540

guggaccuca uaaccuucac agaggggagu ggaagauccc cuagguaugc ccugugguuu      600

ugcgucggcg aaucuuggcc ccaggaucag ccauggacca aacggcuugu gauggugaag      660

gucguuccca cuugucugcg cgcuuuggug gagauggcac gaguaggcgg ggccagcucc      720

cucgaaaaca caguggaccu gcacaucuca aauagucauc cuuuaagccu gaccucugau      780

caguacaaag ccuaucucca agaccuuguc gagggaaugg auuuccaggg uccaggcgaa      840

acguga                                                                 846


<210>  8799
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__ADN86149

<400>  8799
auggugcugg ccccccugcc cgaccccggc ccccccagcc uggccguggc ccccgagccc       60

ugcccccagc cccugagaag ccccagccug gacaacccca cccccuuccc caaccugggc      120

cccagcgaga acccccugaa gagacugcug gugcccggcg aggaguggga guucgaggug      180

accgccuucu acagaggcag acagguguuc cagcagacca ucagcugccc cgagggccug      240

agacuggugg gcagcgaggu gggcgacaga acccugcccg gcuggcccgu gacccugccc      300

gaccccggca ugagccugac cgacagaggc gugaugagcu acgugagaca cgugcugagc      360

ugccugggcg gcggccuggc ccuguggaga gccggccagu ggcugugggc ccagagacug      420

ggccacugcc acaccuacug ggccgugagc gaggagcugc ugcccaacag cggccacggc      480

cccgacggcg aggugcccaa ggacaaggag ggcggcgugu ucgaccuggg ccccuucauc      540

guggaccuga ucaccuucac cgagggcagc ggcagaagcc ccagauacgc ccugugguuc      600

ugcgugggcg agagcuggcc ccaggaccag cccuggacca agagacuggu gauggugaag      660

guggugccca ccugccugag agcccuggug gagauggcca gagugggcgg cgccagcagc      720

cuggagaaca ccguggaccu gcacaucagc aacagccacc cccugagccu gaccagcgac      780

caguacaagg ccuaccugca ggaccuggug gagggcaugg acuuccaggg ccccggcgag      840

accuga                                                                 846


<210>  8800
<211>  846
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__ADN86149

<400>  8800
auggugcugg cuccccuccc ugacccgggg cccccuagcc uggccgucgc ccccgagccu       60

ugcccccagc cucuuagauc cccgucucug gauaacccca ccccuuuccc caaucucggg      120

ccuagcgaaa acccccugaa gcggcuucug guuccgggag aggaauggga guuugaagug      180

acagcguucu accgcggcag acaaguguuu cagcagacga ucuccugucc ugaggggcuc      240

cggcuggucg gaucugaggu gggcgaccgc acccugcccg gguggccugu uacacucccc      300

gaucccggaa ugagccugac cgacagaggc gugauguccu auguccggca cgugcuuucu      360

ugccugggcg ggggacucgc ucuguggcgc gccggccagu ggcuuugggc ccaaagacug      420

gggcauuguc acacauacug ggcuguuagc gaggaacucc ugccuaauuc cggacauggc      480

ccggaugggg aagugcccaa agacaaggag ggaggcgucu ucgaucuggg cccuuuuauu      540

guggaccuca ucaccuucac agaggggagc ggacggucuc cccgcuaugc ccugugguuu      600

ugcgugggcg aauccuggcc ucaggaucag cccuggacca aaagacuugu caugguuaag      660

guggugccga cgugucugcg ggcucucguc gagauggccc gcgugggcgg agcgagcucu      720

cuggaaaaca ccguugaccu ucacauuucc aauagccauc cucugucucu cacauccgau      780

caguacaaag ccuaucugca agaccuggug gagggcaugg auuuccaggg gcccggagaa      840

accuga                                                                 846


<210>  8801
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__E2GIM8

<400>  8801

Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu Ala Val 
1               5                   10                  15      


Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu Asp Asn 
            20                  25                  30          


Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu Lys Arg 
        35                  40                  45              


Leu Leu Val Pro Gly Glu Asp Leu Ile Thr Phe Thr Glu Gly Ser Gly 
    50                  55                  60                  


Arg Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp Pro 
65                  70                  75                  80  


Gln Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val Pro 
                85                  90                  95      


Thr Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala Ser 
            100                 105                 110         


Ser Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro Leu 
        115                 120                 125             


Ser Leu Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val Glu 
    130                 135                 140                 


Gly Met Asp Phe Gln Gly Pro Gly Glu Thr 
145                 150                 


<210>  8802
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__ADN86150

<400>  8802
augguguugg ccccacuccc agauccggga cccccaagcc uggcuguagc cccugagccc       60

ugcccucagc cccugcggag ccccagcuug gacaauccca cucccuuccc aaaccugggg      120

cccucugaga acccacugaa gcggcuguug gugccggggg aagaucugau uaccuucacg      180

gaaggaagcg gacgcucacc acgcuaugcc cucugguucu guguggggga gucauggccc      240

caggaccagc cguggaccaa gaggcucgug auggucaagg uugugcccac gugccucagg      300

gccuugguag aaauggcccg gguagggggu gccuccuccc uggagaauac uguggaccug      360

cacauuucca acagccaccc acucucccuc accuccgacc aguacaaggc cuaccugcag      420

gacuuggugg agggcaugga uuuccagggc ccuggggaga ccuga                      465


<210>  8803
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__ADN86150

<400>  8803
auggugcugg cgccccuccc ggaccccggc ccgcccagcc uggccgucgc ccccgagccc       60

ugcccccagc cccugcgcuc cccgagccuc gacaacccca cccccuuccc caaccugggg      120

ccguccgaga acccccugaa gcggcuccug gugcccggcg aggaccugau caccuucacg      180

gaggggagcg gccgcagccc ccgguacgcc cucugguucu gcguggggga guccuggccg      240

caggaccagc ccuggaccaa gcgccugguc auggugaagg uggucccgac cugccugcgg      300

gcccucgugg agauggcccg cgugggcggc gccuccagcc uggagaacac cgucgaccug      360

cacaucucca acagccaccc ccucucccug acgagcgacc aguacaaggc guaccugcag      420

gaccucgugg aggggaugga cuuccagggc cccggggaga ccuga                      465


<210>  8804
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__ADN86150

<400>  8804
augguccucg ccccccuccc cgaccccggc ccccccuccc ucgccgucgc ccccgagccc       60

ugcccccagc cccuccgcuc ccccucccuc gacaacccca cccccuuccc caaccucggc      120

cccuccgaga acccccucaa gcgccuccuc guccccggcg aggaccucau caccuucacc      180

gagggcuccg gccgcucccc ccgcuacgcc cucugguucu gcgucggcga guccuggccc      240

caggaccagc ccuggaccaa gcgccucguc auggucaagg ucguccccac cugccuccgc      300

gcccucgucg agauggcccg cgucggcggc gccuccuccc ucgagaacac cgucgaccuc      360

cacaucucca acucccaccc ccucucccuc accuccgacc aguacaaggc cuaccuccag      420

gaccucgucg agggcaugga cuuccagggc cccggcgaga ccuga                      465


<210>  8805
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__ADN86150

<400>  8805
auggugcugg cuccccuccc ugacccaggc ccgcccagcc uugccgucgc accugagcca       60

ugcccccagc cucugagauc cccaucuuug gauaacccca ccccuuuccc aaauuuaggg      120

ccgucagaaa acccccugaa gaggcuacuc guuccuggag aggaccugau cacauuuacu      180

gaagguagug gccggagccc acgcuacgcc cuuugguucu guguggggga guccuggccc      240

caagaucagc cuuggacgaa acgacuggua auggugaagg ucgugccaac cugcuugcgu      300

gcgcucguug aaauggcuag agugggaggc gccucuucgc uggagaauac agucgaccug      360

cacauuucaa acagccaucc ccucaguuua acuuccgauc aguauaaagc auaccugcag      420

gaccuugugg aggguaugga uuuucaaggg ccgggagaaa ccuga                      465


<210>  8806
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__ADN86150

<400>  8806
auggugcugg ccccccugcc cgaccccggc ccccccagcc uggccguggc ccccgagccc       60

ugcccccagc cccugagaag ccccagccug gacaacccca cccccuuccc caaccugggc      120

cccagcgaga acccccugaa gagacugcug gugcccggcg aggaccugau caccuucacc      180

gagggcagcg gcagaagccc cagauacgcc cugugguucu gcgugggcga gagcuggccc      240

caggaccagc ccuggaccaa gagacuggug auggugaagg uggugcccac cugccugaga      300

gcccuggugg agauggccag agugggcggc gccagcagcc uggagaacac cguggaccug      360

cacaucagca acagccaccc ccugagccug accagcgacc aguacaaggc cuaccugcag      420

gaccuggugg agggcaugga cuuccagggc cccggcgaga ccuga                      465


<210>  8807
<211>  465
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__ADN86150

<400>  8807
auggugcugg cuccccuccc ugacccgggg cccccuagcc uggcugucgc ccccgagccu       60

ugcccccagc cucuuagauc cccgucucug gauaacccca ccccuuuccc caaucucggc      120

ccuagcgaaa acccccugaa gcggcuucug guuccgggag aggaccucau cacauuuacg      180

gaaggcuccg ggcgcucucc uagauacgcg cugugguucu gugugggaga gagcuggccc      240

caagaucagc cuuggaccaa acggcuggug auggucaagg ugguucccac augccuccgc      300

gcucuggugg aaauggccag agucggcggg gccuccucuc uugagaauac cguggaccug      360

cacauuagca acucccaucc ccucagccug acaucugauc aguauaaagc cuaccuucag      420

gaccugguug agggaaugga uuuucaaggc ccuggcgaaa ccuga                      465


<210>  8808
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__E2GIM9

<400>  8808

Met Gly Thr Pro Lys Pro Arg Ile Leu Pro Trp Leu Val Ser Gln Leu 
1               5                   10                  15      


Asp Leu Gly Gln Leu Glu Gly Val Ala Trp Val Asn Lys Ser Arg Thr 
            20                  25                  30          


Arg Phe Arg Ile Pro Trp Lys His Gly Leu Arg Gln Asp Ala Gln Gln 
        35                  40                  45              


Glu Asp Phe Gly Ile Phe Gln Ala Trp Ala Glu Ala Thr Gly Ala Tyr 
    50                  55                  60                  


Val Pro Gly Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe 
65                  70                  75                  80  


Arg Ser Ala Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg 
                85                  90                  95      


Ser Lys Asp Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser 
            100                 105                 110         


Gly Val Gly Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly 
        115                 120                 125             


Gly Gly Ser Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu 
    130                 135                 140                 


Gly Asn Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu 
145                 150                 155                 160 


Ala Val Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu 
                165                 170                 175     


Asp Asn Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu 
            180                 185                 190         


Lys Arg Leu Leu Val Pro Gly Glu Asp Leu Ile Thr Phe Thr Glu Gly 
        195                 200                 205             


Ser Gly Arg Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser 
    210                 215                 220                 


Trp Pro Gln Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val 
225                 230                 235                 240 


Val Pro Thr Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly 
                245                 250                 255     


Ala Ser Ser Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His 
            260                 265                 270         


Pro Leu Ser Leu Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu 
        275                 280                 285             


Val Glu Gly Met Asp Phe Gln Gly Pro Gly Glu Thr 
    290                 295                 300 


<210>  8809
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__ADN86151

<400>  8809
augggaaccc caaagccacg gauccugccc uggcuggugu cgcagcugga ccuggggcaa       60

cuggagggcg uggccugggu gaacaagagc cgcacgcgcu uccgcauccc uuggaagcac      120

ggccuacggc aggaugcaca gcaggaggau uucggaaucu uccaggccug ggccgaggcc      180

acuggugcau auguucccgg gagggauaag ccagaccugc caaccuggaa gaggaauuuc      240

cgcucugccc ucaaccgcaa agaaggguug cguuuagcag aggaccggag caaggacccu      300

cacgacccac auaaaaucua cgaguuugug aacucaggag uuggggacuu uucccagcca      360

gacaccucuc cggacaccaa ugguggaggc aguacuucug auacccagga agacauucug      420

gacgaguuac uggguaacau gguguuggcc ccacucccag auccgggacc cccaagccug      480

gcuguagccc cugagcccug cccucagccc cugcggagcc ccagcuugga caaucccacu      540

cccuucccaa accuggggcc cucugagaac ccacugaagc ggcuguuggu gccgggggaa      600

gaucugauua ccuucacgga aggaagcgga cguucaccac gcuaugcccu cugguucugu      660

gugggggagu cauggcccca ggaccagccg uggaccaaga ggcucgugau ggucaagguu      720

gugcccacgu gccucagggc cuugguagaa auggcccggg uagggggugc cuccucccug      780

gagaauacug uggaccugca cauuuccaac agccacccac ucucccucac cuccgaccag      840

uacaaggccu accugcagga cuugguggag ggcauggauu uccagggccc uggggagacc      900

uga                                                                    903


<210>  8810
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__ADN86151

<400>  8810
augggcaccc ccaagccgcg cauccugccc uggcucguga gccagcugga ccuggggcag       60

cucgagggcg ucgccugggu gaacaagucc cggacccgcu uccggauccc cuggaagcac      120

gggcugcgcc aggacgccca gcaggaggac uucggcaucu uccaggcgug ggccgaggcc      180

acgggggccu acgugcccgg ccgggacaag ccggaccugc ccaccuggaa gcgcaacuuc      240

cggagcgccc ucaaccgcaa ggagggccug cggcuggcgg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacagcgggg ugggcgacuu cucccagccg      360

gacaccagcc ccgacaccaa cgggggcggg uccacgagcg acacccagga ggacauccuc      420

gacgagcugc ugggcaacau ggugcucgcg ccccugcccg acccgggccc gcccucccug      480

gccgucgccc ccgagcccug cccccagccc cuccggagcc ccucccugga caacccgacc      540

cccuucccca accuggggcc cagcgagaac ccgcucaagc gccugcuggu gcccggcgag      600

gaccucauca ccuucacgga gggguccggc cggagccccc gcuacgcccu gugguucugc      660

gugggcgagu ccuggcccca ggaccagccg uggaccaagc ggcuggucau ggugaaggug      720

gucccgaccu gccuccgcgc ccugguggag auggcccggg ucgggggcgc cagcucccug      780

gagaacaccg uggaccucca caucagcaac ucccaccccc ugagccugac gagcgaccag      840

uacaaggccu accuccagga ccugguggag gggauggacu uccagggccc cggggagacc      900

uga                                                                    903


<210>  8811
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__ADN86151

<400>  8811
augggcaccc ccaagccccg cauccucccc uggcucgucu cccagcucga ccucggccag       60

cucgagggcg ucgccugggu caacaagucc cgcacccgcu uccgcauccc cuggaagcac      120

ggccuccgcc aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acguccccgg ccgcgacaag cccgaccucc ccaccuggaa gcgcaacuuc      240

cgcuccgccc ucaaccgcaa ggagggccuc cgccucgccg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacuccggcg ucggcgacuu cucccagccc      360

gacaccuccc ccgacaccaa cggcggcggc uccaccuccg acacccagga ggacauccuc      420

gacgagcucc ucggcaacau gguccucgcc ccccuccccg accccggccc ccccucccuc      480

gccgucgccc ccgagcccug cccccagccc cuccgcuccc ccucccucga caaccccacc      540

cccuucccca accucggccc cuccgagaac ccccucaagc gccuccucgu ccccggcgag      600

gaccucauca ccuucaccga gggcuccggc cgcucccccc gcuacgcccu cugguucugc      660

gucggcgagu ccuggcccca ggaccagccc uggaccaagc gccucgucau ggucaagguc      720

guccccaccu gccuccgcgc ccucgucgag auggcccgcg ucggcggcgc cuccucccuc      780

gagaacaccg ucgaccucca caucuccaac ucccaccccc ucucccucac cuccgaccag      840

uacaaggccu accuccagga ccucgucgag ggcauggacu uccagggccc cggcgagacc      900

uga                                                                    903


<210>  8812
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__ADN86151

<400>  8812
augggcaccc ccaagccuag aauccugcca uggcucguga gccagcuuga ccuggggcaa       60

uuggagggag ucgccugggu uaacaaaucc aggacacggu uccgcauucc guggaagcac      120

gguuuacgac aggaugcuca gcaggaagac uuuggcauau uccaagcaug ggccgaggcg      180

acuggggcuu acgugcccgg acgugauaaa ccugaccugc caacguggaa gagaaauuuu      240

aggucugccc uaaaccggaa agaaggccuc cgccuggcag aggauagauc aaaggacccc      300

caugauccuc acaagaucua ugaguucgua aauaguggug ugggggacuu uagccagcca      360

gauaccuccc ccgacacaaa cggaggcggc ucuacuucgg auacccagga agacauucuu      420

gaugagcugu uggggaauau gguccucgcc ccucugccag acccgggacc cccuucacug      480

gcuguggcac cagaacccug cccucagcca cucaggagcc ccaguuuaga caacccgaca      540

ccuuucccca aucugggucc auccgagaac ccucuuaaac gguugcuggu ucccggcgaa      600

gaucuaauca ccuuuacuga ggggucugga cgcagcccac gauacgcccu cugguucugu      660

gugggcgagu ccuggcccca agaccagccu uggacaaaga gacuggucau ggugaaagua      720

guuccaaccu gccuuagggc ucugguggaa auggcccggg ucgguggggc gucaaguuug      780

gagaauacgg uggaucucca uauuagcaac ucucacccgc uguccuuaac uucagaccag      840

uauaaggcau accugcagga ucucguggaa ggaauggacu uucaaggccc cggcgagacc      900

uga                                                                    903


<210>  8813
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__ADN86151

<400>  8813
augggcaccc ccaagcccag aauccugccc uggcugguga gccagcugga ccugggccag       60

cuggagggcg uggccugggu gaacaagagc agaaccagau ucagaauccc cuggaagcac      120

ggccugagac aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acgugcccgg cagagacaag cccgaccugc ccaccuggaa gagaaacuuc      240

agaagcgccc ugaacagaaa ggagggccug agacuggccg aggacagaag caaggacccc      300

cacgaccccc acaagaucua cgaguucgug aacagcggcg ugggcgacuu cagccagccc      360

gacaccagcc ccgacaccaa cggcggcggc agcaccagcg acacccagga ggacauccug      420

gacgagcugc ugggcaacau ggugcuggcc ccccugcccg accccggccc ccccagccug      480

gccguggccc ccgagcccug cccccagccc cugagaagcc ccagccugga caaccccacc      540

cccuucccca accugggccc cagcgagaac ccccugaaga gacugcuggu gcccggcgag      600

gaccugauca ccuucaccga gggcagcggc agaagcccca gauacgcccu gugguucugc      660

gugggcgaga gcuggcccca ggaccagccc uggaccaaga gacuggugau ggugaaggug      720

gugcccaccu gccugagagc ccugguggag auggccagag ugggcggcgc cagcagccug      780

gagaacaccg uggaccugca caucagcaac agccaccccc ugagccugac cagcgaccag      840

uacaaggccu accugcagga ccugguggag ggcauggacu uccagggccc cggcgagacc      900

uga                                                                    903


<210>  8814
<211>  903
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__ADN86151

<400>  8814
augggcaccc ccaagccuag aauccugccg uggcucguga gccagcugga ccuugggcaa       60

cuggagggag ucgccugggu uaacaaaucc cggacacgcu uccggauucc cuggaagcac      120

ggccucagac aggaugcuca gcaggaagac uuugggaucu uccaagccug ggcggaggcu      180

acgggagccu acgugccugg ccgcgauaaa cccgaccugc cuaccuggaa gagaaauuuu      240

cggucugccc uuaaccgcaa agaagggcug agacucgcug aggaucggag caaggacccc      300

caugauccuc acaagauuua ugaguucguc aauuccggag ugggcgacuu uucucagccg      360

gauacaagcc ccgacaccaa cggcggggga uccacaucug auacccagga agacauccug      420

gaugagcugc ucggcaauau ggugcuggcc ccucuucccg acccugggcc cccgagccug      480

gcuguugccc cugaacccug cccucagccc cuccgcuccc ccagccugga caacccuaca      540

ccguucccca aucuuggacc uucugagaac ccccugaaaa gacuccuggu gccuggcgaa      600

gaucugauua ccuuuacgga gggguccgga cggagccccc gcuacgcgcu cugguucugu      660

gucggcgagu cuuggccgca agaccagccu uggaccaaga gacuggugau gguuaaagug      720

guccccacau gccuucgggc ccugguggaa auggcucgcg ugggcggggc cuccagccuc      780

gagaauaccg ucgaucugca uaucucuaac ucccacccuc uuagccugac auccgaccag      840

uauaaggcuu accuccagga ucugguugaa ggaauggacu uucaaggccc cggggagacc      900

uga                                                                    903


<210>  8815
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__Q14653

<400>  8815

Met Gly Thr Pro Lys Pro Arg Ile Leu Pro Trp Leu Val Ser Gln Leu 
1               5                   10                  15      


Asp Leu Gly Gln Leu Glu Gly Val Ala Trp Val Asn Lys Ser Arg Thr 
            20                  25                  30          


Arg Phe Arg Ile Pro Trp Lys His Gly Leu Arg Gln Asp Ala Gln Gln 
        35                  40                  45              


Glu Asp Phe Gly Ile Phe Gln Ala Trp Ala Glu Ala Thr Gly Ala Tyr 
    50                  55                  60                  


Val Pro Gly Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe 
65                  70                  75                  80  


Arg Ser Ala Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg 
                85                  90                  95      


Ser Lys Asp Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser 
            100                 105                 110         


Gly Val Gly Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly 
        115                 120                 125             


Gly Gly Ser Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu 
    130                 135                 140                 


Gly Asn Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu 
145                 150                 155                 160 


Ala Val Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu 
                165                 170                 175     


Asp Asn Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu 
            180                 185                 190         


Lys Arg Leu Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala 
        195                 200                 205             


Phe Tyr Arg Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu 
    210                 215                 220                 


Gly Leu Arg Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly 
225                 230                 235                 240 


Trp Pro Val Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly 
                245                 250                 255     


Val Met Ser Tyr Val Arg His Val Leu Ser Cys Leu Gly Gly Gly Leu 
            260                 265                 270         


Ala Leu Trp Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His 
        275                 280                 285             


Cys His Thr Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly 
    290                 295                 300                 


His Gly Pro Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe 
305                 310                 315                 320 


Asp Leu Gly Pro Phe Ile Val Asp Leu Ile Thr Phe Thr Glu Gly Ser 
                325                 330                 335     


Gly Arg Ser Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp 
            340                 345                 350         


Pro Gln Asp Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val 
        355                 360                 365             


Pro Thr Cys Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala 
    370                 375                 380                 


Ser Ser Leu Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro 
385                 390                 395                 400 


Leu Ser Leu Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val 
                405                 410                 415     


Glu Gly Met Asp Phe Gln Gly Pro Gly Glu Ser 
            420                 425         


<210>  8816
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__AAH71721

<400>  8816
augggaaccc caaagccacg gauccugccc uggcuggugu cgcagcugga ccuggggcaa       60

cuggagggcg uggccugggu gaacaagagc cgcacgcgcu uccgcauccc uuggaagcac      120

ggccuacggc aggaugcaca gcaggaggau uucggaaucu uccaggccug ggccgaggcc      180

acuggugcau auguucccgg gagggauaag ccagaccugc caaccuggaa gaggaauuuc      240

cgcucugccc ucaaccgcaa agaaggguug cguuuagcag aggaccggag caaggacccu      300

cacgacccac auaaaaucua cgaguuugug aacucaggag uuggggacuu uucccagcca      360

gacaccucuc cggacaccaa ugguggaggc aguacuucug auacccagga agacauucug      420

gaugaguuac uggguaacau gguguuggcc ccacucccag auccgggacc cccaagccug      480

gcuguagccc cugagcccug cccucagccc cugcggagcc ccagcuugga caaucccacu      540

cccuucccaa accuggggcc cucugagaac ccacugaagc ggcuguuggu gccgggggaa      600

gagugggagu ucgaggugac agccuucuac cggggccgcc aagucuucca gcagaccauc      660

uccugcccgg agggccugcg gcuggugggg uccgaagugg gagacaggac gcugccugga      720

uggccaguca cacugccaga cccuggcaug ucccugacag acaggggagu gaugagcuac      780

gugaggcaug ugcugagcug ccuggguggg ggacuggcuc ucuggcgggc cgggcagugg      840

cucugggccc agcggcuggg gcacugccac acauacuggg cagugagcga ggagcugcuc      900

cccaacagcg ggcaugggcc ugauggcgag guccccaagg acaaggaagg aggcguguuu      960

gaccuggggc ccuucauugu agaucugauu accuucacgg aaggaagcgg acgcucacca     1020

cgcuaugccc ucugguucug ugugggggag ucauggcccc aggaccagcc guggaccaag     1080

aggcucguga uggucaaggu ugugcccacg ugccucaggg ccuugguaga aauggcccgg     1140

guagggggug ccuccucccu ggagaauacu guggaccugc acauuuccaa cagccaccca     1200

cucucccuca ccuccgacca guacaaggcc uaccugcagg acuuggugga gggcauggau     1260

uuccagggcc cuggggagag cuga                                            1284


<210>  8817
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__AAH71721

<400>  8817
augggcaccc ccaagccgcg cauccugccc uggcucguga gccagcugga ccuggggcag       60

cucgagggcg ucgccugggu gaacaagucc cggacccgcu uccggauccc cuggaagcac      120

gggcugcgcc aggacgccca gcaggaggac uucggcaucu uccaggcgug ggccgaggcc      180

acgggggccu acgugcccgg ccgggacaag ccggaccugc ccaccuggaa gcgcaacuuc      240

cggagcgccc ucaaccgcaa ggagggccug cggcuggcgg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacagcgggg ugggcgacuu cucccagccg      360

gacaccagcc ccgacaccaa cgggggcggg uccacgagcg acacccagga ggacauccuc      420

gacgagcugc ugggcaacau ggugcucgcg ccccugcccg acccgggccc gcccucccug      480

gccgucgccc ccgagcccug cccccagccc cuccggagcc ccucccugga caacccgacc      540

cccuucccca accuggggcc cagcgagaac ccgcucaagc gccugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac cgggggcgcc aggucuucca gcagacgauc      660

uccugccccg agggccuccg gcuggugggc agcgaggugg gggaccgcac ccugcccggc      720

uggccgguca cccuccccga ccccgggaug ucccugaccg accggggcgu gaugagcuac      780

gugcgccacg uccuguccug ccucgggggc ggccuggccc uguggcgggc cgggcagugg      840

cucugggccc agcgccuggg ccacugccac acguacuggg ccgugagcga ggagcugcuc      900

ccgaacuccg ggcacggccc cgacggggag gugcccaagg acaaggaggg cggcgucuuc      960

gaccuggggc ccuucaucgu ggaccugauc accuucaccg agggcagcgg gcggagcccg     1020

cgcuacgcgc ucugguucug cgugggcgag uccuggcccc aggaccagcc cuggaccaag     1080

cgccugguca uggugaaggu gguccccacg ugccugcggg cccucgugga gauggcccgc     1140

gucgggggcg ccagcucccu ggagaacacc guggaccugc acaucagcaa cucccacccg     1200

cucagccuga ccuccgacca guacaaggcc uaccugcagg accucgugga gggcauggac     1260

uuccaggggc ccggcgagag cuga                                            1284


<210>  8818
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__AAH71721

<400>  8818
augggcaccc ccaagccccg cauccucccc uggcucgucu cccagcucga ccucggccag       60

cucgagggcg ucgccugggu caacaagucc cgcacccgcu uccgcauccc cuggaagcac      120

ggccuccgcc aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acguccccgg ccgcgacaag cccgaccucc ccaccuggaa gcgcaacuuc      240

cgcuccgccc ucaaccgcaa ggagggccuc cgccucgccg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacuccggcg ucggcgacuu cucccagccc      360

gacaccuccc ccgacaccaa cggcggcggc uccaccuccg acacccagga ggacauccuc      420

gacgagcucc ucggcaacau gguccucgcc ccccuccccg accccggccc ccccucccuc      480

gccgucgccc ccgagcccug cccccagccc cuccgcuccc ccucccucga caaccccacc      540

cccuucccca accucggccc cuccgagaac ccccucaagc gccuccucgu ccccggcgag      600

gagugggagu ucgaggucac cgccuucuac cgcggccgcc aggucuucca gcagaccauc      660

uccugccccg agggccuccg ccucgucggc uccgaggucg gcgaccgcac ccuccccggc      720

uggcccguca cccuccccga ccccggcaug ucccucaccg accgcggcgu cauguccuac      780

guccgccacg uccucuccug ccucggcggc ggccucgccc ucuggcgcgc cggccagugg      840

cucugggccc agcgccucgg ccacugccac accuacuggg ccgucuccga ggagcuccuc      900

cccaacuccg gccacggccc cgacggcgag guccccaagg acaaggaggg cggcgucuuc      960

gaccucggcc ccuucaucgu cgaccucauc accuucaccg agggcuccgg ccgcuccccc     1020

cgcuacgccc ucugguucug cgucggcgag uccuggcccc aggaccagcc cuggaccaag     1080

cgccucguca uggucaaggu cguccccacc ugccuccgcg cccucgucga gauggcccgc     1140

gucggcggcg ccuccucccu cgagaacacc gucgaccucc acaucuccaa cucccacccc     1200

cucucccuca ccuccgacca guacaaggcc uaccuccagg accucgucga gggcauggac     1260

uuccagggcc ccggcgaguc cuga                                            1284


<210>  8819
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__AAH71721

<400>  8819
augggcaccc ccaagccuag aauccugcca uggcucguga gccagcuuga ccuggggcaa       60

uuggagggag ucgccugggu uaacaaaucc aggacacggu uccgcauucc guggaagcac      120

gguuuacgac aggaugcuca gcaggaagac uuuggcauau uccaagcaug ggccgaggcg      180

acuggggcuu acgugcccgg acgugauaaa ccugaccugc caacguggaa gagaaauuuu      240

aggucugccc uaaaccggaa agaaggccuc cgccuggcag aggauagauc aaaggacccc      300

caugauccuc acaagaucua ugaguucgua aauaguggug ugggggacuu uagccagcca      360

gauaccuccc ccgacacaaa cggaggcggc ucuacuucgg auacccagga agacauucuu      420

gaugagcugu uggggaauau gguccucgcc ccucugccag acccgggacc cccuucacug      480

gcuguggcac cagaacccug cccucagcca cucaggagcc ccaguuuaga caacccgaca      540

ccuuucccca aucugggucc auccgagaac ccucuuaaac gguugcuggu ucccggcgaa      600

gagugggagu uugaagugac cgccuucuac cgcgggcgac aagucuuuca gcagacuauc      660

ucuuguccag agggacuaag acucgugggc agcgaaguag gugauaggac acugcccggg      720

uggccuguua cccuuccaga cccgggaaug ucccugacgg aucggggcgu gaugucauau      780

guccgucaug uguugaguug ccucggcggg ggacuggcuu uauggcgcgc cggucagugg      840

cugugggcgc aaagacucgg ccacugucau acuuacuggg cagugagcga ggaacuucug      900

cccaauucug ggcacggacc ugacggcgag gucccaaagg auaaagaggg ugggguuuuc      960

gacuugggcc ccuuuauugu ggaucuaauc accuucacag aaggauccgg caggucaccu     1020

cgguaugccc ugugguuuug cguaggggag agcuggccac aggaccagcc cuggacuaag     1080

cgacucguga uggucaaagu gguuccgacc ugucugcgcg cucuugugga aauggccaga     1140

gucggaggug caaguucucu ggagaacaca guggauuugc acauauccaa uagccauccu     1200

cucucgcuga ccucugacca auacaaggcu uauuuacagg aucugguaga aggcauggac     1260

uuccaggggc caggagaguc cuga                                            1284


<210>  8820
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__AAH71721

<400>  8820
augggcaccc ccaagcccag aauccugccc uggcugguga gccagcugga ccugggccag       60

cuggagggcg uggccugggu gaacaagagc agaaccagau ucagaauccc cuggaagcac      120

ggccugagac aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acgugcccgg cagagacaag cccgaccugc ccaccuggaa gagaaacuuc      240

agaagcgccc ugaacagaaa ggagggccug agacuggccg aggacagaag caaggacccc      300

cacgaccccc acaagaucua cgaguucgug aacagcggcg ugggcgacuu cagccagccc      360

gacaccagcc ccgacaccaa cggcggcggc agcaccagcg acacccagga ggacauccug      420

gacgagcugc ugggcaacau ggugcuggcc ccccugcccg accccggccc ccccagccug      480

gccguggccc ccgagcccug cccccagccc cugagaagcc ccagccugga caaccccacc      540

cccuucccca accugggccc cagcgagaac ccccugaaga gacugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac agaggcagac agguguucca gcagaccauc      660

agcugccccg agggccugag acuggugggc agcgaggugg gcgacagaac ccugcccggc      720

uggcccguga cccugcccga ccccggcaug agccugaccg acagaggcgu gaugagcuac      780

gugagacacg ugcugagcug ccugggcggc ggccuggccc uguggagagc cggccagugg      840

cugugggccc agagacuggg ccacugccac accuacuggg ccgugagcga ggagcugcug      900

cccaacagcg gccacggccc cgacggcgag gugcccaagg acaaggaggg cggcguguuc      960

gaccugggcc ccuucaucgu ggaccugauc accuucaccg agggcagcgg cagaagcccc     1020

agauacgccc ugugguucug cgugggcgag agcuggcccc aggaccagcc cuggaccaag     1080

agacugguga uggugaaggu ggugcccacc ugccugagag cccuggugga gauggccaga     1140

gugggcggcg ccagcagccu ggagaacacc guggaccugc acaucagcaa cagccacccc     1200

cugagccuga ccagcgacca guacaaggcc uaccugcagg accuggugga gggcauggac     1260

uuccagggcc ccggcgagag cuga                                            1284


<210>  8821
<211>  1284
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__AAH71721

<400>  8821
augggcaccc ccaagccuag aauccugccg uggcucguga gccagcugga ccuugggcaa       60

cuggagggag ucgccugggu uaacaaaucc cggacacgcu uccggauucc cuggaagcac      120

ggccucagac aggaugcuca gcaggaagac uuugggaucu uccaagccug ggcggaggcu      180

acgggagccu acgugccugg ccgcgauaaa cccgaccugc cuaccuggaa gagaaauuuu      240

cggucugccc uuaaccgcaa agaagggcug agacucgcug aggaucggag caaggacccc      300

caugauccuc acaagauuua ugaguucguc aauuccggag ugggcgacuu uucucagccg      360

gauacaagcc ccgacaccaa cggcggggga uccacaucug auacccagga agacauccug      420

gaugagcugc ucggcaauau ggugcuggcc ccucuucccg acccugggcc cccgagccug      480

gcuguugccc cugaacccug cccucagccc cuccgcuccc ccagccugga caacccuaca      540

ccguucccca aucuuggacc uucugagaac ccccugaaaa gacuccuggu gccuggcgaa      600

gagugggagu uugaagucac cgcguucuac cgggggcgcc aaguguuuca gcagacgauu      660

uccugucccg agggacugag acucguuggc agcgaagugg gcgaucggac ccugccgggg      720

uggccuguca cacuucccga cccuggaaug ucucugaccg aucgcggcgu gauguccuau      780

gugagacaug uccucagcug ccuuggggga ggccuggccc uguggcgggc ugggcagugg      840

cucugggccc aaagacuggg acacugucau acauacuggg cuguuucuga ggaacugcuc      900

cccaauuccg gccacggccc ugacggggag gugcccaagg auaaagaggg aggcguguuc      960

gaccuggggc cguuuaucgu cgaucuuauc accuucacgg aaggaagcgg ccgcuccccu     1020

cgguaugccc ugugguuuug cgugggggag ucuuggcccc aggaccagcc cuggacaaag     1080

agacucguua uggugaaagu cgugccuacc ugucugcgcg cgcuuguuga aauggcccgg     1140

gugggcggag cuagcucccu ggagaacaca gucgaucucc acauuagcaa uucucauccg     1200

cugucccuga ccagcgacca auacaaggcc uaucuccagg aucuggugga aggcauggac     1260

uuccaggggc ccggagaguc uuga                                            1284


<210>  8822
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__Q96GL3

<400>  8822

Met Gly Thr Pro Lys Pro Arg Ile Leu Pro Trp Leu Val Ser Gln Leu 
1               5                   10                  15      


Asp Leu Gly Gln Leu Glu Gly Val Ala Trp Val Asn Lys Ser Arg Thr 
            20                  25                  30          


Arg Phe Arg Ile Pro Trp Lys His Gly Leu Arg Gln Asp Ala Gln Gln 
        35                  40                  45              


Glu Asp Phe Gly Ile Phe Gln Ala Trp Ala Glu Ala Thr Gly Ala Tyr 
    50                  55                  60                  


Val Pro Gly Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe 
65                  70                  75                  80  


Arg Ser Ala Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg 
                85                  90                  95      


Ser Lys Asp Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser 
            100                 105                 110         


Gly Val Gly Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly 
        115                 120                 125             


Gly Gly Ser Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu 
    130                 135                 140                 


Gly Asn Met Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu 
145                 150                 155                 160 


Ala Val Ala Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu 
                165                 170                 175     


Asp Asn Pro Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu 
            180                 185                 190         


Lys Arg Leu Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala 
        195                 200                 205             


Phe Tyr Arg Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu 
    210                 215                 220                 


Gly Leu Arg Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly 
225                 230                 235                 240 


Trp Pro Val Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly 
                245                 250                 255     


Val Met Ser Tyr Val Arg His Val Leu Ser Cys Leu Gly Gly Gly Leu 
            260                 265                 270         


Ala Leu Trp Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His 
        275                 280                 285             


Cys His Thr Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly 
    290                 295                 300                 


His Gly Pro Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe 
305                 310                 315                 320 


Asp Leu Gly Pro Phe Ile Val Gly Ser Trp Ala Pro Arg Ser Asp Tyr 
                325                 330                 335     


Leu His Gly Arg Lys Arg Thr Leu Thr Thr Leu Cys Pro Leu Val Leu 
            340                 345                 350         


Cys Gly Gly Val Met Ala Pro Gly Pro Ala Val Asp Gln Glu Ala Arg 
        355                 360                 365             


Asp Gly Gln Gly Cys Ala His Val Pro Gln Gly Leu Gly Arg Asn Gly 
    370                 375                 380                 


Pro Gly Arg Gly Cys Leu Leu Pro Gly Glu Tyr Cys Gly Pro Ala His 
385                 390                 395                 400 


Phe Gln Gln Pro Pro Thr Leu Pro His Leu Arg Pro Val Gln Gly Leu 
                405                 410                 415     


Pro Ala Gly Leu Gly Gly Gly His Gly Phe Pro Gly Pro Trp Gly Asp 
            420                 425                 430         


Leu Ser Pro Arg Ser Ser Trp Cys Ala Ser Asn Pro Pro Val Pro His 
        435                 440                 445             


His Leu Asn Gln 
    450         


<210>  8823
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF3__Homo_sapiens__AAH09395

<400>  8823
augggaaccc caaagccacg gauccugccc uggcuggugu cgcagcugga ccuggggcaa       60

cuggagggcg uggccugggu gaacaagagc cgcacgcgcu uccgcauccc uuggaagcac      120

ggccuacggc aggaugcaca gcaggaggau uucggaaucu uccaggccug ggccgaggcc      180

acuggugcau auguucccgg gagggauaag ccagaccugc caaccuggaa gaggaauuuc      240

cgcucugccc ucaaccgcaa agaaggguug cguuuagcag aggaccggag caaggacccu      300

cacgacccac auaaaaucua cgaguuugug aacucaggag uuggggacuu uucccagcca      360

gacaccucuc cggacaccaa ugguggaggc aguacuucug auacccagga agacauucug      420

gaugaguuac uggguaacau gguguuggcc ccacucccag auccgggacc cccaagccug      480

gcuguagccc cugagcccug cccucagccc cugcggagcc ccagcuugga caaucccacu      540

cccuucccaa accuggggcc cucugagaac ccacugaagc ggcuguuggu gccgggggaa      600

gagugggagu ucgaggugac agccuucuac cggggccgcc aagucuucca gcagaccauc      660

uccugcccgg agggccugcg gcuggugggg uccgaagugg gagacaggac gcugccugga      720

uggccaguca cacugccaga cccuggcaug ucccugacag acaggggagu gaugagcuac      780

gugaggcaug ugcugagcug ccuggguggg ggacuggcuc ucuggcgggc cgggcagugg      840

cucugggccc agcggcuggg gcacugccac acauacuggg cagugagcga ggagcugcuc      900

cccaacagcg ggcaugggcc ugauggcgag guccccaagg acaaggaagg aggcguguuu      960

gaccuggggc ccuucauugu aggcuccugg gcccccagau cugauuaccu ucacggaagg     1020

aagcggacgc ucaccacgcu augcccucug guucugugug ggggagucau ggccccagga     1080

ccagccgugg accaagaggc ucgugauggu caagguugug cccacgugcc ucagggccuu     1140

gguagaaaug gcccggguag ggggugccuc cucccuggag aauacugugg accugcacau     1200

uuccaacagc cacccacucu cccucaccuc cgaccaguac aaggccuacc ugcaggacuu     1260

gguggagggc auggauuucc agggcccugg ggagaccuga gcccucgcuc cucauggugu     1320

gccuccaacc ccccuguucc ccaccaccuc aaccaauaa                            1359


<210>  8824
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF3__Homo_sapiens__AAH09395

<400>  8824
augggcaccc ccaagccgcg cauccugccc uggcucguga gccagcugga ccuggggcag       60

cucgagggcg ucgccugggu gaacaagucc cggacccgcu uccggauccc cuggaagcac      120

gggcugcgcc aggacgccca gcaggaggac uucggcaucu uccaggcgug ggccgaggcc      180

acgggggccu acgugcccgg ccgggacaag ccggaccugc ccaccuggaa gcgcaacuuc      240

cggagcgccc ucaaccgcaa ggagggccug cggcuggcgg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacagcgggg ugggcgacuu cucccagccg      360

gacaccagcc ccgacaccaa cgggggcggg uccacgagcg acacccagga ggacauccuc      420

gacgagcugc ugggcaacau ggugcucgcg ccccugcccg acccgggccc gcccucccug      480

gccgucgccc ccgagcccug cccccagccc cuccggagcc ccucccugga caacccgacc      540

cccuucccca accuggggcc cagcgagaac ccgcucaagc gccugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac cgggggcgcc aggucuucca gcagacgauc      660

uccugccccg agggccuccg gcuggugggc agcgaggugg gggaccgcac ccugcccggc      720

uggccgguca cccuccccga ccccgggaug ucccugaccg accggggcgu gaugagcuac      780

gugcgccacg uccuguccug ccucgggggc ggccuggccc uguggcgggc cgggcagugg      840

cucugggccc agcgccuggg ccacugccac acguacuggg ccgugagcga ggagcugcuc      900

ccgaacuccg ggcacggccc cgacggggag gugcccaagg acaaggaggg cggcgucuuc      960

gaccuggggc ccuucaucgu gggcagcugg gcgccgcgga gcgacuaccu gcacgggcgc     1020

aagcgcaccc ucaccacccu gugcccccug gugcucugcg gcggggucau ggcccccggc     1080

cccgccgugg accaggaggc ccgggacggc caggggugcg cccacgugcc gcagggccug     1140

gggcgcaacg gccccggccg ggggugccug cuccccggcg aguacugcgg gcccgcgcac     1200

uuccagcagc cgcccacgcu gccccaccuc cgccccgucc agggccugcc ggccgggcug     1260

ggcggcgggc acggcuuccc cgggcccugg ggcgaccuga gcccccgguc cuccuggugc     1320

gccagcaacc cgcccgugcc ccaccaccuc aaccaguga                            1359


<210>  8825
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF3__Homo_sapiens__AAH09395

<400>  8825
augggcaccc ccaagccccg cauccucccc uggcucgucu cccagcucga ccucggccag       60

cucgagggcg ucgccugggu caacaagucc cgcacccgcu uccgcauccc cuggaagcac      120

ggccuccgcc aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acguccccgg ccgcgacaag cccgaccucc ccaccuggaa gcgcaacuuc      240

cgcuccgccc ucaaccgcaa ggagggccuc cgccucgccg aggaccgcuc caaggacccc      300

cacgaccccc acaagaucua cgaguucguc aacuccggcg ucggcgacuu cucccagccc      360

gacaccuccc ccgacaccaa cggcggcggc uccaccuccg acacccagga ggacauccuc      420

gacgagcucc ucggcaacau gguccucgcc ccccuccccg accccggccc ccccucccuc      480

gccgucgccc ccgagcccug cccccagccc cuccgcuccc ccucccucga caaccccacc      540

cccuucccca accucggccc cuccgagaac ccccucaagc gccuccucgu ccccggcgag      600

gagugggagu ucgaggucac cgccuucuac cgcggccgcc aggucuucca gcagaccauc      660

uccugccccg agggccuccg ccucgucggc uccgaggucg gcgaccgcac ccuccccggc      720

uggcccguca cccuccccga ccccggcaug ucccucaccg accgcggcgu cauguccuac      780

guccgccacg uccucuccug ccucggcggc ggccucgccc ucuggcgcgc cggccagugg      840

cucugggccc agcgccucgg ccacugccac accuacuggg ccgucuccga ggagcuccuc      900

cccaacuccg gccacggccc cgacggcgag guccccaagg acaaggaggg cggcgucuuc      960

gaccucggcc ccuucaucgu cggcuccugg gccccccgcu ccgacuaccu ccacggccgc     1020

aagcgcaccc ucaccacccu cugcccccuc guccucugcg gcggcgucau ggcccccggc     1080

cccgccgucg accaggaggc ccgcgacggc cagggcugcg cccacguccc ccagggccuc     1140

ggccgcaacg gccccggccg cggcugccuc cuccccggcg aguacugcgg ccccgcccac     1200

uuccagcagc cccccacccu cccccaccuc cgccccgucc agggccuccc cgccggccuc     1260

ggcggcggcc acggcuuccc cggccccugg ggcgaccucu ccccccgcuc cuccuggugc     1320

gccuccaacc cccccguccc ccaccaccuc aaccaguga                            1359


<210>  8826
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF3__Homo_sapiens__AAH09395

<400>  8826
augggcaccc ccaagccuag aauccugcca uggcucguga gccagcuuga ccuggggcaa       60

uuggagggag ucgccugggu uaacaaaucc aggacacggu uccgcauucc guggaagcac      120

gguuuacgac aggaugcuca gcaggaagac uuuggcauau uccaagcaug ggccgaggcg      180

acuggggcuu acgugcccgg acgugauaaa ccugaccugc caacguggaa gagaaauuuu      240

aggucugccc uaaaccggaa agaaggccuc cgccuggcag aggauagauc aaaggacccc      300

caugauccuc acaagaucua ugaguucgua aauaguggug ugggggacuu uagccagcca      360

gauaccuccc ccgacacaaa cggaggcggc ucuacuucgg auacccagga agacauucuu      420

gaugagcugu uggggaauau gguccucgcc ccucugccag acccgggacc cccuucacug      480

gcuguggcac cagaacccug cccucagcca cucaggagcc ccaguuuaga caacccgaca      540

ccuuucccca aucugggucc auccgagaac ccucuuaaac gguugcuggu ucccggcgaa      600

gagugggagu uugaagugac cgccuucuac cgcgggcgac aagucuuuca gcagacuauc      660

ucuuguccag agggacuaag acucgugggc agcgaaguag gugauaggac acugcccggg      720

uggccuguua cccuuccaga cccgggaaug ucccugacgg aucggggcgu gaugucauau      780

guccgucaug uguugaguug ccucggcggg ggacuggcuu uauggcgcgc cggucagugg      840

cugugggcgc aaagacucgg ccacugucau acuuacuggg cagugagcga ggaacuucug      900

cccaauucug ggcacggacc ugacggcgag gucccaaagg auaaagaggg ugggguuuuc      960

gacuugggcc ccuuuauugu gggauccugg gccccuaggu cagauuaucu acacggccgg     1020

aagcgaaccc ugacaacucu cugcccacug guacuuugug ggggagugau ggcucccggu     1080

ccggccgucg accaggaagc acgcgauggc caggggugcg cucaugugcc ucaaggacug     1140

ggcagaaacg guccagggag gggcuguuug cuccccggag aguacugcgg cccugcccac     1200

uuccagcagc ccccaacccu gccucauuua cggcccguuc aggggcugcc agcgggacua     1260

gguggcgggc acggauuucc gggcccuugg ggugaccuca gcccccgcag uucuuggugu     1320

gccuccaauc cacccgugcc ucaccaucug aaccaauga                            1359


<210>  8827
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF3__Homo_sapiens__AAH09395

<400>  8827
augggcaccc ccaagcccag aauccugccc uggcugguga gccagcugga ccugggccag       60

cuggagggcg uggccugggu gaacaagagc agaaccagau ucagaauccc cuggaagcac      120

ggccugagac aggacgccca gcaggaggac uucggcaucu uccaggccug ggccgaggcc      180

accggcgccu acgugcccgg cagagacaag cccgaccugc ccaccuggaa gagaaacuuc      240

agaagcgccc ugaacagaaa ggagggccug agacuggccg aggacagaag caaggacccc      300

cacgaccccc acaagaucua cgaguucgug aacagcggcg ugggcgacuu cagccagccc      360

gacaccagcc ccgacaccaa cggcggcggc agcaccagcg acacccagga ggacauccug      420

gacgagcugc ugggcaacau ggugcuggcc ccccugcccg accccggccc ccccagccug      480

gccguggccc ccgagcccug cccccagccc cugagaagcc ccagccugga caaccccacc      540

cccuucccca accugggccc cagcgagaac ccccugaaga gacugcuggu gcccggcgag      600

gagugggagu ucgaggugac cgccuucuac agaggcagac agguguucca gcagaccauc      660

agcugccccg agggccugag acuggugggc agcgaggugg gcgacagaac ccugcccggc      720

uggcccguga cccugcccga ccccggcaug agccugaccg acagaggcgu gaugagcuac      780

gugagacacg ugcugagcug ccugggcggc ggccuggccc uguggagagc cggccagugg      840

cugugggccc agagacuggg ccacugccac accuacuggg ccgugagcga ggagcugcug      900

cccaacagcg gccacggccc cgacggcgag gugcccaagg acaaggaggg cggcguguuc      960

gaccugggcc ccuucaucgu gggcagcugg gcccccagaa gcgacuaccu gcacggcaga     1020

aagagaaccc ugaccacccu gugcccccug gugcugugcg gcggcgugau ggcccccggc     1080

cccgccgugg accaggaggc cagagacggc cagggcugcg cccacgugcc ccagggccug     1140

ggcagaaacg gccccggcag aggcugccug cugcccggcg aguacugcgg ccccgcccac     1200

uuccagcagc cccccacccu gccccaccug agacccgugc agggccugcc cgccggccug     1260

ggcggcggcc acggcuuccc cggccccugg ggcgaccuga gccccagaag cagcuggugc     1320

gccagcaacc cccccgugcc ccaccaccug aaccaguga                            1359


<210>  8828
<211>  1359
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF3__Homo_sapiens__AAH09395

<400>  8828
augggcaccc ccaagccuag aauccugccg uggcucguga gccagcugga ccuugggcaa       60

cuggagggag ucgccugggu uaacaaaucc cggacacgcu uccggauucc cuggaagcac      120

ggccucagac aggaugcuca gcaggaagac uuugggaucu uccaagccug ggcggaggcu      180

acgggagccu acgugccugg ccgcgauaaa cccgaccugc cuaccuggaa gagaaauuuu      240

cggucugccc uuaaccgcaa agaagggcug agacucgcug aggaucggag caaggacccc      300

caugauccuc acaagauuua ugaguucguc aauuccggag ugggcgacuu uucucagccg      360

gauacaagcc ccgacaccaa cggcggggga uccacaucug auacccagga agacauccug      420

gaugagcugc ucggcaauau ggugcuggcc ccucuucccg acccugggcc cccgagccug      480

gcuguugccc cugaacccug cccucagccc cuccgcuccc ccagccugga caacccuaca      540

ccguucccca aucuuggacc uucugagaac ccccugaaaa gacuccuggu gccuggcgaa      600

gagugggagu uugaagucac cgcguucuac cgggggcgcc aaguguuuca gcagacgauu      660

uccugucccg agggacugag acucguuggc agcgaagugg gcgaucggac ccugccgggg      720

uggccuguca cacuucccga cccuggaaug ucucugaccg aucgcggcgu gauguccuau      780

gugagacaug uccucagcug ccuuggggga ggccuggccc uguggcgggc ugggcagugg      840

cucugggccc aaagacuggg acacugucau acauacuggg cuguuucuga ggaacugcuc      900

cccaauuccg gccacggccc ugacggggag gugcccaagg auaaagaggg aggcguguuc      960

gaccuggggc cguuuaucgu cggaagcugg gccccucgcu ccgauuaucu ucacggccgg     1020

aagagaaccc ugacgacacu cugcccccug gugcuuugug ggggcguuau ggcgcccgga     1080

ccugccgugg accaggaagc ucgcgauggc caggggugcg cccauguccc gcaaggacug     1140

ggccggaacg ggcccggaag aggcugucuc cugccugggg aguacugcgg ccccgcucac     1200

uuccagcagc cucccacccu gccucaucuc cgccccgugc agggacugcc ggccggccuu     1260

gggggaggcc acggguuucc uggacccugg ggcgaccugu cuccucggag cuccuggugu     1320

gccagcaauc ccccgguucc ucaccaucuc aaccaauga                            1359


<210>  8829
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IRF-7__Homo_sapiens__Q92985

<400>  8829

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
225                 230                 235                 240 


Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                245                 250                 255     


Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
            260                 265                 270         


Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
        275                 280                 285             


Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
    290                 295                 300                 


Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
305                 310                 315                 320 


Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                325                 330                 335     


Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
            340                 345                 350         


Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
        355                 360                 365             


Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
    370                 375                 380                 


Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
385                 390                 395                 400 


Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                405                 410                 415     


Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
            420                 425                 430         


Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
        435                 440                 445             


Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
    450                 455                 460                 


Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
465                 470                 475                 480 


Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                485                 490                 495     


Met Glu Leu Glu Gln Pro Ala 
            500             


<210>  8830
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  IRF-7__Homo_sapiens__AAB80686

<400>  8830
auggccuugg cuccugagag ggcagcccca cgcgugcugu ucggagagug gcuccuugga       60

gagaucagca gcggcugcua ugaggggcug caguggcugg acgaggcccg caccuguuuc      120

cgcgugcccu ggaagcacuu cgcgcgcaag gaccugagcg aggccgacgc gcgcaucuuc      180

aaggccuggg cuguggcccg cggcaggugg ccgccuagca gcaggggagg uggcccgccc      240

cccgaggcug agacugcgga gcgcgccggc uggaaaacca acuuccgcug cgcacugcgc      300

agcacgcguc gcuucgugau gcugcgggau aacucggggg acccggccga cccgcacaag      360

guguacgcgc ucagccggga gcugugcugg cgagaaggcc caggcacgga ccagacugag      420

gcagaggccc ccgcagcugu cccaccacca cagggugggc ccccagggcc auucuuggca      480

cacacacaug cuggacucca agccccaggc ccccucccug ccccagcugg ugacaagggg      540

gaccuccugc uccaggcagu gcaacagagc ugccuggcag accaucugcu gacagcguca      600

uggggggcag auccaguccc aaccaaggcu ccuggagagg gacaagaagg gcuuccccug      660

acuggggccu gugcuggagg cccagggcuc ccugcugggg agcuguacgg gugggcagua      720

gagacgaccc ccagccccgg gccccagccc gcggcacuaa cgacaggcga ggccgcggcc      780

ccagaguccc cgcaccaggc agagccguac cugucacccu ccccaagcgc cugcaccgcg      840

gugcaagagc ccagcccagg ggcgcuggac gugaccauca uguacaaggg ccgcacggug      900

cugcagaagg uggugggaca cccgagcugc acguuccuau acggcccccc agacccagcu      960

guccgggcca cagaccccca gcagguagca uuccccagcc cugccgagcu cccggaccag     1020

aagcagcugc gcuacacgga ggaacugcug cggcacgugg ccccuggguu gcaccuggag     1080

cuucgggggc cacagcugug ggcccggcgc augggcaagu gcaaggugua cugggaggug     1140

ggcggacccc caggcuccgc cagccccucc accccagccu gccugcugcc ucggaacugu     1200

gacaccccca ucuucgacuu cagagucuuc uuccaagagc ugguggaauu ccgggcacgg     1260

cagcgccgug gcuccccacg cuauaccauc uaccugggcu ucgggcagga ccugucagcu     1320

gggaggccca aggagaagag ccugguccug gugaagcugg aacccuggcu gugccgagug     1380

caccuagagg gcacgcagcg ugagggugug ucuucccugg auagcagcag ccucagccuc     1440

ugccugucca gcgccaacag ccucuaugac gacaucgagu gcuuccuuau ggagcuggag     1500

cagcccgccu ag                                                         1512


<210>  8831
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       IRF-7__Homo_sapiens__AAB80686

<400>  8831
auggcccugg cccccgagcg cgcggccccg cggguccucu ucggcgagug gcugcugggg       60

gagaucagcu ccggcugcua cgaggggcuc caguggcugg acgaggcccg gaccugcuuc      120

cgcgugcccu ggaagcacuu cgcccgcaag gaccugagcg aggccgacgc gcggaucuuc      180

aaggccuggg ccguggcccg cggccggugg ccgcccucca gccgcggggg cgggcccccg      240

cccgaggcgg agaccgccga gcgggccggc uggaagacga acuuccgcug cgcccuccgg      300

uccacccgcc gguucgugau gcugcgcgac aacagcggcg accccgccga cccccacaag      360

gucuacgcgc ugucccggga gcucugcugg cgcgaggggc ccggcaccga ccagaccgag      420

gccgaggccc ccgccgccgu gcccccgccc cagggcgggc cgcccggccc cuuccuggcg      480

cacacgcacg ccgggcugca ggcccccggc ccccuccccg ccccggccgg ggacaagggc      540

gaccugcugc uccaggcggu gcagcagagc ugccuggccg accaccuccu gaccgccucc      600

uggggcgccg accccguccc caccaaggcc cccggggagg gccaggaggg gcugccgcug      660

accggcgcgu gcgccggggg ccccggccuc cccgccgggg agcuguacgg cugggccgug      720

gagacgaccc ccagcccggg gccccagccc gcggcccuga ccaccggcga ggccgccgcc      780

ccggagagcc cccaccaggc ggagcccuac cucagccccu ccccgagcgc cugcacggcc      840

gugcaggagc ccucccccgg ggcccuggac gucaccauca uguacaaggg ccggaccgug      900

cugcagaagg uggucggcca ccccagcugc accuuccucu acgggccgcc cgaccccgcc      960

gugcgcgcga cggaccccca gcaggucgcc uucccguccc ccgccgagcu gcccgaccag     1020

aagcagcugc gguacaccga ggagcuccug cgccacgugg cccccggccu gcaccucgag     1080

cugcgggggc cgcagcugug ggcccgccgc augggcaagu gcaaggugua cugggagguc     1140

gggggcccgc ccggcagcgc gucccccagc acccccgccu gccuccugcc ccggaacugc     1200

gacaccccca ucuucgacuu ccgcguguuc uuccaggagc ugguggaguu ccgggcccgc     1260

cagcggcgcg ggagcccccg guacacgauc uaccucggcu ucgggcagga ccuguccgcc     1320

ggccgcccga aggagaaguc ccuggugcuc gucaagcugg agcccuggcu gugccgggug     1380

caccucgagg gcacccagcg cgagggggug uccagccugg acuccagcuc ccugagccuc     1440

ugccugucca gcgcgaacuc ccuguacgac gacaucgagu gcuuccugau ggagcucgag     1500

cagcccgccu ga                                                         1512


<210>  8832
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       IRF-7__Homo_sapiens__AAB80686

<400>  8832
auggcccucg cccccgagcg cgccgccccc cgcguccucu ucggcgagug gcuccucggc       60

gagaucuccu ccggcugcua cgagggccuc caguggcucg acgaggcccg caccugcuuc      120

cgcguccccu ggaagcacuu cgcccgcaag gaccucuccg aggccgacgc ccgcaucuuc      180

aaggccuggg ccgucgcccg cggccgcugg ccccccuccu cccgcggcgg cggccccccc      240

cccgaggccg agaccgccga gcgcgccggc uggaagacca acuuccgcug cgcccuccgc      300

uccacccgcc gcuucgucau gcuccgcgac aacuccggcg accccgccga cccccacaag      360

gucuacgccc ucucccgcga gcucugcugg cgcgagggcc ccggcaccga ccagaccgag      420

gccgaggccc ccgccgccgu cccccccccc cagggcggcc cccccggccc cuuccucgcc      480

cacacccacg ccggccucca ggcccccggc ccccuccccg cccccgccgg cgacaagggc      540

gaccuccucc uccaggccgu ccagcagucc ugccucgccg accaccuccu caccgccucc      600

uggggcgccg accccguccc caccaaggcc cccggcgagg gccaggaggg ccucccccuc      660

accggcgccu gcgccggcgg ccccggccuc cccgccggcg agcucuacgg cugggccguc      720

gagaccaccc ccucccccgg cccccagccc gccgcccuca ccaccggcga ggccgccgcc      780

cccgaguccc cccaccaggc cgagcccuac cucucccccu cccccuccgc cugcaccgcc      840

guccaggagc ccucccccgg cgcccucgac gucaccauca uguacaaggg ccgcaccguc      900

cuccagaagg ucgucggcca ccccuccugc accuuccucu acggcccccc cgaccccgcc      960

guccgcgcca ccgaccccca gcaggucgcc uuccccuccc ccgccgagcu ccccgaccag     1020

aagcagcucc gcuacaccga ggagcuccuc cgccacgucg cccccggccu ccaccucgag     1080

cuccgcggcc cccagcucug ggcccgccgc augggcaagu gcaaggucua cugggagguc     1140

ggcggccccc ccggcuccgc cucccccucc acccccgccu gccuccuccc ccgcaacugc     1200

gacaccccca ucuucgacuu ccgcgucuuc uuccaggagc ucgucgaguu ccgcgcccgc     1260

cagcgccgcg gcuccccccg cuacaccauc uaccucggcu ucggccagga ccucuccgcc     1320

ggccgcccca aggagaaguc ccucguccuc gucaagcucg agcccuggcu cugccgcguc     1380

caccucgagg gcacccagcg cgagggcguc uccucccucg acuccuccuc ccucucccuc     1440

ugccucuccu ccgccaacuc ccucuacgac gacaucgagu gcuuccucau ggagcucgag     1500

cagcccgccu ga                                                         1512


<210>  8833
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       IRF-7__Homo_sapiens__AAB80686

<400>  8833
auggcccugg cucccgagag agcagccccu aggguucucu ucggcgaaug gcuucugggg       60

gagaucagcu ccggaugcua cgaagguuug cagugguuag acgaggcgcg gaccuguuuu      120

cgcgucccau ggaagcacuu cgcucgaaaa gaucugucug aagccgacgc acguauuuuu      180

aaggccuggg cuguugcaag agggaggugg ccgcccucaa gucggggcgg aggcccucca      240

cccgaggccg agacagcuga acgcgccggu uggaaaacua acuucagaug cgcgcuaagg      300

agcacgcggc gcuuugugau gcuccgagau aauuccgggg acccugcaga uccacauaag      360

guauaugccc ugucuagaga gcuuuguugg agggaaggac ccggcaccga ccaaacagag      420

gcugaggccc cugcagcugu gccaccgccc cagggcgggc cuccaggacc cuuccuggcc      480

cacacucaug cggguuugca ggccccuggc ccacuccccg caccggcugg ggauaaagga      540

gaccugcugc uccaggccgu ccaacagucg ugcuuagcug aucaucugcu uaccgccuca      600

uggggcgcag acccugugcc cacaaaggcc ccaggugaag ggcaggaggg auugccucug      660

accggcgcuu gugcgggcgg gcccggacua ccagccggug aacucuacgg cugggcaguu      720

gagacuacac ccagcccugg gccacagccg gcugcccuga ccacgggaga agcagccgcu      780

cccgagaguc cucaccaagc cgagccauau cuuucccccu cuccuagcgc augcacugcg      840

gugcaggaac caucccccgg cgcucuggau gucaccauaa uguacaaggg ucggacagug      900

uugcagaaag uaguugggca cccgucaugu acuuuucucu auggcccucc agaccccgcc      960

gugcgugcaa ccgauccuca gcaagucgcc uuccccaguc cagcugagcu gccugaccag     1020

aagcaguuac gcuacacaga ggaacugcuc agacacgugg cccccggacu ucaucuggaa     1080

uugaggggcc cacaacuaug ggcacggcga auggggaaau gcaaggugua uugggagguc     1140

ggagguccgc cuggcagcgc uucucccucc accccagccu gucugcuccc ccgcaacugc     1200

gacacgccua ucuuugauuu cagaguguuu uuccaggagc ugguggaauu uagggcgcgg     1260

cagcgcagag ggucaccaag guacacuauu uaccuuggau ucggccagga ccugagcgcc     1320

ggucguccca aagagaagag uuugguacuc gugaagcugg aaccuugguu augucggguc     1380

caccuggagg ggacacaacg agaaggcgug ucuucccuag auagcucguc ucucucccug     1440

ugccuuucaa gugcuaauag cuuguaugac gauaucgagu gcuuccugau ggagcucgaa     1500

cagccggcau ga                                                         1512


<210>  8834
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       IRF-7__Homo_sapiens__AAB80686

<400>  8834
auggcccugg cccccgagag agccgccccc agagugcugu ucggcgagug gcugcugggc       60

gagaucagca gcggcugcua cgagggccug caguggcugg acgaggccag aaccugcuuc      120

agagugcccu ggaagcacuu cgccagaaag gaccugagcg aggccgacgc cagaaucuuc      180

aaggccuggg ccguggccag aggcagaugg ccccccagca gcagaggcgg cggccccccc      240

cccgaggccg agaccgccga gagagccggc uggaagacca acuucagaug cgcccugaga      300

agcaccagaa gauucgugau gcugagagac aacagcggcg accccgccga cccccacaag      360

guguacgccc ugagcagaga gcugugcugg agagagggcc ccggcaccga ccagaccgag      420

gccgaggccc ccgccgccgu gccccccccc cagggcggcc cccccggccc cuuccuggcc      480

cacacccacg ccggccugca ggcccccggc ccccugcccg cccccgccgg cgacaagggc      540

gaccugcugc ugcaggccgu gcagcagagc ugccuggccg accaccugcu gaccgccagc      600

uggggcgccg accccgugcc caccaaggcc cccggcgagg gccaggaggg ccugccccug      660

accggcgccu gcgccggcgg ccccggccug cccgccggcg agcuguacgg cugggccgug      720

gagaccaccc ccagccccgg cccccagccc gccgcccuga ccaccggcga ggccgccgcc      780

cccgagagcc cccaccaggc cgagcccuac cugagcccca gccccagcgc cugcaccgcc      840

gugcaggagc ccagccccgg cgcccuggac gugaccauca uguacaaggg cagaaccgug      900

cugcagaagg uggugggcca ccccagcugc accuuccugu acggcccccc cgaccccgcc      960

gugagagcca ccgaccccca gcagguggcc uuccccagcc ccgccgagcu gcccgaccag     1020

aagcagcuga gauacaccga ggagcugcug agacacgugg cccccggccu gcaccuggag     1080

cugagaggcc cccagcugug ggccagaaga augggcaagu gcaaggugua cugggaggug     1140

ggcggccccc ccggcagcgc cagccccagc acccccgccu gccugcugcc cagaaacugc     1200

gacaccccca ucuucgacuu cagaguguuc uuccaggagc ugguggaguu cagagccaga     1260

cagagaagag gcagccccag auacaccauc uaccugggcu ucggccagga ccugagcgcc     1320

ggcagaccca aggagaagag ccuggugcug gugaagcugg agcccuggcu gugcagagug     1380

caccuggagg gcacccagag agagggcgug agcagccugg acagcagcag ccugagccug     1440

ugccugagca gcgccaacag ccuguacgac gacaucgagu gcuuccugau ggagcuggag     1500

cagcccgccu ga                                                         1512


<210>  8835
<211>  1512
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       IRF-7__Homo_sapiens__AAB80686

<400>  8835
auggcccugg cucccgagag agccgcgccu cggguccucu ucggcgaaug gcugcuuggg       60

gagaucagcu ccggaugcua cgaaggccug caguggcucg acgaggcucg caccuguuuu      120

agagucccgu ggaagcacuu cgcccggaaa gaucugucug aagccgacgc ucgcauuuuu      180

aaggccuggg cuguugccag agggcggugg cccccuagcu cccgcggagg cgggcccccu      240

cccgaggcgg agacagccga aagagcugga uggaaaacga acuuccggug cgcccuucgc      300

ucuaccagac gguuugugau gcugcgcgau aauagcggcg acccugcuga uccgcauaag      360

guguaugccc ucuccagaga gcuguguugg cgggaaggcc ccgggacaga ccaaaccgag      420

gcggaggccc cugcugccgu gcccccuccc cagggaggcc cgccugggcc cuuccuggcu      480

cacacacaug ccggacucca ggccccuggc ccccugcccg cuccugcggg ggauaaagga      540

gaccuucugc uccaggccgu gcaacagucu ugccuggcug aucaccuucu gaccgccagc      600

uggggcgccg acccgguucc cacaaaggcu ccuggcgaag ggcaggaggg acucccccug      660

accggcgccu gugcuggggg accuggccug cccgcggggg aacucuacgg augggccgug      720

gagacgaccc cguccccugg cccccagccu gccgcucuga caaccggcga agccgcugcc      780

cccgagagcc cucaucaagc ggagcccuau cuuucuccgu ccccuagcgc cugcacagcu      840

guccaggaac ccucucccgg ggcccuggau gugaccauca uguacaaggg acgcacgguu      900

cuccagaaag uggucggcca cccuuccugu acauuucugu augggccgcc cgacccugcu      960

gugagagcca ccgaucccca gcaaguggcg uucccuagcc ccgccgagcu uccugaccag     1020

aagcagcugc gguacacaga ggagcuccug agacacgucg cucccggacu gcaucucgaa     1080

cugcgcggcc cgcaacuuug ggcccggaga auggggaaau gcaagguuua uugggaggug     1140

ggcggaccuc ccggcucugc uuccccuagc acccccgccu gucugcuccc gcgcaacugc     1200

gacaccccua uuuuugauuu ccggguguuu uuccaggagc uggucgaauu uagagcccgc     1260

cagcggagag ggucuccccg cuacacaauc uaccuuggau ucggccagga ccuguccgcu     1320

gggcggccua aagaaaagag ccucgugcug guuaagcugg aacccuggcu cuguagagug     1380

caccuggagg gaacgcaacg cgaaggcguc uccagccuug auucuuccag ccugucucuc     1440

ugccugagcu ccgccaauuc ucuguaugac gauauugagu gcuuccuuau ggagcucgaa     1500

cagcccgcgu ga                                                         1512


<210>  8836
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK__Homo_sapiens__B4DU99

<400>  8836

Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Trp Ala 
1               5                   10                  15      


Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser 
            20                  25                  30          


Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys Thr 
        35                  40                  45              


Leu Arg Ile Gln Gln Arg Glu Leu Glu Glu Lys Gly Lys Ala Gln His 
    50                  55                  60                  


Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln Val Thr 
65                  70                  75                  80  


Val Leu Lys Glu Pro Leu Ser Cys Ala Arg Arg Ile Ser Ser Pro Arg 
                85                  90                  95      


Glu Gln Val Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His Pro 
            100                 105                 110         


Pro Pro Ser Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser Gln 
        115                 120                 125             


Ala Gly Gly Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro Lys 
    130                 135                 140                 


His His Arg Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys Asn 
145                 150                 155                 160 


Asp Ala Ser Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys Glu 
                165                 170                 175     


Ile Ile Gln Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu Leu 
            180                 185                 190         


Val Leu Lys Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr Leu 
        195                 200                 205             


Ile Gln Ala Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp Lys 
    210                 215                 220                 


Leu Lys Gly Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys Thr 
225                 230                 235                 240 


Gln Lys Tyr Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met Glu 
                245                 250                 255     


Asp Gln Lys Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln Lys 
            260                 265                 270         


Val Leu Glu Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr Gln 
        275                 280                 285             


Val Trp Gly Cys His Ile Asp Met Gly Leu Gly Thr Pro Gly Ser Leu 
    290                 295                 300                 


Gly Asn Lys Gly Ser Gln Leu His Asn Ser Leu Glu Pro Ser Pro Leu 
305                 310                 315                 320 






<210>  8837
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  JNK__Homo_sapiens__BAG62261

<400>  8837
augaucagcc cagaccccag gcccuccccu ggcuuggccc ggugggcuga gagcuaugag       60

gccaagugug agcgcaggca agagauccgu gaaagccgcc gcugccgucc caaugugacc      120

acuugccgcc agguggggaa gacgcugagg auccaacaga gagagcuaga ggagaagggc      180

aaagcgcagc auccccaggc cagggagcaa gggcccucca ggcggccagg acaggugacu      240

guccucaagg aacccuuguc uugugccaga aggauuucuu cucccagaga gcaggugaca      300

ggcaccagcu cugaagucuu uccagcccag cauccuccuc ccucaggcau cugcagggau      360

cugucugacc accucuccuc acaggcuggg ggccuuccuc cacaggacac ucccaucaag      420

aagccaccca aacaccaccg ugguacucag acaaaggcag aaggaccaac aauuaagaac      480

gaugccaguc agcaaaccaa uuacggaguu gcaguucugg auaaggaaau cauccagcuu      540

ucugauuacc ucaaagaggc ccuacaaagg gagcuggucc uaaaacagaa aauggugauu      600

cuccaagacc uacuguccac ucugauucag gccucugaca gcucuuggaa gggacagcuu      660

aaugaagaca aacuaaaggg gaaacugaga uccuuagaaa accagcuaua caccuguacc      720

cagaaauacu ccccuugggg aaugaaaaaa guacuacugg agauggaaga ccagaaaaac      780

agcuaugagc agaaggccaa ggagucacug cagaaagugc uggaggagaa aaugaaugca      840

gagcagcaac uacagagcac acagguaugg ggaugccaca uagacauggg gcuggggacu      900

ccaggcagcu uggggaacaa ggggagccag cugcacaacu cccuggagcc cucuccucuc      960

uga                                                                    963


<210>  8838
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       JNK__Homo_sapiens__BAG62261

<400>  8838
augaucuccc ccgacccccg ccccuccccc ggccuggccc ggugggccga gagcuacgag       60

gcgaagugcg agcgccggca ggagauccgc gagucccggc gcugccggcc caacgugacg      120

accugccgcc aggucgggaa gacccuccgg auccagcagc gcgagcugga ggagaagggc      180

aaggcccagc acccgcaggc ccgggagcag gggcccagcc gccggcccgg ccaggugacc      240

gugcugaagg agccccucuc cugcgcccgc cggaucagcu ccccgcgcga gcaggucacc      300

gggaccagcu ccgagguguu ccccgcccag cacccgccgc ccagcggcau cugccgggac      360

cuguccgacc accugagcuc ccaggcgggc gggcucccgc cccaggacac gcccaucaag      420

aagccgccca agcaccaccg cggcacccag accaaggccg aggggcccac caucaagaac      480

gacgccagcc agcagacgaa cuacggcgug gccguccugg acaaggagau cauccagcug      540

uccgacuacc ucaaggaggc gcugcagcgg gagcuggugc ucaagcagaa gauggugauc      600

cugcaggacc ugcucagcac ccugauccag gccuccgaca gcuccuggaa ggggcagcug      660

aacgaggaca agcucaaggg caagcugcgc agccuggaga accagcucua cacgugcacc      720

cagaaguaca gccccugggg caugaagaag guccugcugg agauggagga ccagaagaac      780

uccuacgagc agaaggccaa ggagagccuc cagaaggugc uggaggagaa gaugaacgcc      840

gagcagcagc ugcaguccac ccaggugugg gggugccaca ucgacauggg ccucgggacc      900

cccggcagcc ugggcaacaa ggggucccag cugcacaaca gccucgagcc cagcccccug      960

uga                                                                    963


<210>  8839
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       JNK__Homo_sapiens__BAG62261

<400>  8839
augaucuccc ccgacccccg ccccuccccc ggccucgccc gcugggccga guccuacgag       60

gccaagugcg agcgccgcca ggagauccgc gagucccgcc gcugccgccc caacgucacc      120

accugccgcc aggucggcaa gacccuccgc auccagcagc gcgagcucga ggagaagggc      180

aaggcccagc acccccaggc ccgcgagcag ggccccuccc gccgccccgg ccaggucacc      240

guccucaagg agccccucuc cugcgcccgc cgcaucuccu ccccccgcga gcaggucacc      300

ggcaccuccu ccgaggucuu ccccgcccag cacccccccc ccuccggcau cugccgcgac      360

cucuccgacc accucuccuc ccaggccggc ggccuccccc cccaggacac ccccaucaag      420

aagcccccca agcaccaccg cggcacccag accaaggccg agggccccac caucaagaac      480

gacgccuccc agcagaccaa cuacggcguc gccguccucg acaaggagau cauccagcuc      540

uccgacuacc ucaaggaggc ccuccagcgc gagcucgucc ucaagcagaa gauggucauc      600

cuccaggacc uccucuccac ccucauccag gccuccgacu ccuccuggaa gggccagcuc      660

aacgaggaca agcucaaggg caagcuccgc ucccucgaga accagcucua caccugcacc      720

cagaaguacu cccccugggg caugaagaag guccuccucg agauggagga ccagaagaac      780

uccuacgagc agaaggccaa ggagucccuc cagaaggucc ucgaggagaa gaugaacgcc      840

gagcagcagc uccaguccac ccaggucugg ggcugccaca ucgacauggg ccucggcacc      900

cccggcuccc ucggcaacaa gggcucccag cuccacaacu cccucgagcc cuccccccuc      960

uga                                                                    963


<210>  8840
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       JNK__Homo_sapiens__BAG62261

<400>  8840
augaucagcc ccgacccuag accauccccg ggccuggcca ggugggcuga gucuuacgaa       60

gcaaagugcg agcggcgcca ggaaauucga gagucacgua gauguaggcc caacgugacc      120

acaugccggc aagucgggaa aacucuccgc auacagcaga gagaacuuga ggagaaggga      180

aaagcccagc acccucaagc gagggaacag gguccaaguc ggcgccccgg ccagguuacg      240

gugcugaagg agccuuugag cugugcucga agaaucuccu cuccaaggga acagguaacc      300

gggacaucgu cagagguguu ccccgcccaa cauccuccac cgagcggaau uugccgggau      360

uuaagugacc accuguccuc ucaggcaggc ggucuacccc cucaggauac uccaaucaaa      420

aagcccccua agcaucaccg ugggacccag acaaaagccg agggaccaac cauuaagaau      480

gacgcuagcc aacagacuaa cuauggcguc gcagugcucg auaaagaaau cauacagcug      540

uccgacuacc uuaaggaggc ccugcaacgc gaauugguuc ucaaacagaa gauggugauc      600

cugcaggauc ugcucucaac auuaauucag gcuagugaca gcucuuggaa gggccaacug      660

aaugaggaua aacuuaaggg gaaauugaga ucccuggaaa accagcuaua uaccuguacg      720

cagaaguacu cacccugggg aaugaaaaag guccuccugg agauggagga ccagaaaaau      780

agcuaugaac aaaaggccaa ggagagucuu cagaaagugc uggaagagaa gaugaacgcg      840

gaacagcagu ugcaaucuac ucagguaugg gguugccaua ucgauauggg ccucgggacc      900

ccgggauccc ugggcaauaa agguagccag uuacacaacu cgcuggagcc uucuccccuc      960

uga                                                                    963


<210>  8841
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       JNK__Homo_sapiens__BAG62261

<400>  8841
augaucagcc ccgaccccag acccagcccc ggccuggcca gaugggccga gagcuacgag       60

gccaagugcg agagaagaca ggagaucaga gagagcagaa gaugcagacc caacgugacc      120

accugcagac aggugggcaa gacccugaga auccagcaga gagagcugga ggagaagggc      180

aaggcccagc acccccaggc cagagagcag ggccccagca gaagacccgg ccaggugacc      240

gugcugaagg agccccugag cugcgccaga agaaucagca gccccagaga gcaggugacc      300

ggcaccagca gcgagguguu ccccgcccag cacccccccc ccagcggcau cugcagagac      360

cugagcgacc accugagcag ccaggccggc ggccugcccc cccaggacac ccccaucaag      420

aagcccccca agcaccacag aggcacccag accaaggccg agggccccac caucaagaac      480

gacgccagcc agcagaccaa cuacggcgug gccgugcugg acaaggagau cauccagcug      540

agcgacuacc ugaaggaggc ccugcagaga gagcuggugc ugaagcagaa gauggugauc      600

cugcaggacc ugcugagcac ccugauccag gccagcgaca gcagcuggaa gggccagcug      660

aacgaggaca agcugaaggg caagcugaga agccuggaga accagcugua caccugcacc      720

cagaaguaca gccccugggg caugaagaag gugcugcugg agauggagga ccagaagaac      780

agcuacgagc agaaggccaa ggagagccug cagaaggugc uggaggagaa gaugaacgcc      840

gagcagcagc ugcagagcac ccaggugugg ggcugccaca ucgacauggg ccugggcacc      900

cccggcagcc ugggcaacaa gggcagccag cugcacaaca gccuggagcc cagcccccug      960

uga                                                                    963


<210>  8842
<211>  963
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       JNK__Homo_sapiens__BAG62261

<400>  8842
augaucagcc ccgacccuag accguccccc ggccuggccc ggugggcuga gucuuacgaa       60

gccaagugcg agcgcagaca ggaaauucgg gagagccgca gaugucggcc uaacgugacc      120

acaugccgcc aagucgggaa aacgcucaga auccagcagc gggaacugga ggagaaggga      180

aaagcgcagc acccccaagc ucgcgaacag ggcccuucca gacggcccgg gcagguuacc      240

gugcuuaagg agccucuguc uugugcccgc agaauuagcu ccccgcggga acaggugaca      300

ggaaccucua gcgaggucuu ccccgcccaa cauccucccc cuuccggcau cugccgcgau      360

cucagcgacc accugucuuc ccaggcuggg ggacuucccc cgcaggauac accuauuaaa      420

aagcccccua agcaucacag aggcacccag acaaaagccg agggccccac caucaagaau      480

gacgcuagcc aacagacgaa cuauggggug gccguucugg auaaagaaau cauucagcuc      540

ucugacuacc ugaaggaggc gcugcaacgg gaacucgugc ugaaacagaa gauggucauc      600

cuucaggauc ugcucuccac ccugauucag gccagcgacu cuuccuggaa gggacaacuu      660

aaugaggaua aacugaaggg caaacucaga agccuggaaa accagcugua uacauguacc      720

cagaaguacu cccccugggg gaugaaaaag gugcuccugg agauggagga ccagaaaaau      780

ucuuaugaac aaaaggcuaa ggagagccuu cagaaaguuc uggaagagaa gaugaacgcc      840

gaacagcagc uccaauccac acaggugugg ggaugccaua ucgauauggg ccuggggacc      900

ccuggaagcc uuggcaauaa aggcucucag cugcacaacu cccucgagcc gagcccccug      960

uga                                                                    963


<210>  8843
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCB__Homo_sapiens__P05771-1

<400>  8843

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  8844
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCB__Homo_sapiens__CCDS10618.1

<400>  8844
auggcugacc cggcugcggg gccgccgccg agcgagggcg aggagagcac cgugcgcuuc       60

gcccgcaaag gcgcccuccg gcagaagaac gugcaugagg ucaagaacca caaauucacc      120

gcccgcuucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggcuuc      180

gggaagcagg gauuccagug ccaaguuugc ugcuuugugg ugcacaagcg gugccaugaa      240

uuugucacau ucuccugccc uggcgcugac aaggguccag ccuccgauga cccccgcagc      300

aaacacaagu uuaagaucca cacguacucc agccccacgu uuugugacca cuguggguca      360

cugcuguaug gacucaucca ccaggggaug aaaugugaca ccugcaugau gaaugugcac      420

aagcgcugcg ugaugaaugu ucccagccug uguggcacgg accacacgga gcgccgcggc      480

cgcaucuaca uccaggccca caucgacagg gacguccuca uuguccucgu aagagaugcu      540

aaaaaccuug uaccuaugga ccccaauggc cugucagauc ccuacguaaa acugaaacug      600

auucccgauc ccaaaaguga gagcaaacag aagaccaaaa ccaucaaaug cucccucaac      660

ccugagugga augagacauu uagauuucag cugaaagaau cggacaaaga cagaagacug      720

ucaguagaga uuugggauug ggauuugacc agcaggaaug acuucauggg aucuuugucc      780

uuugggauuu cugaacuuca gaaagccagu guugauggcu gguuuaaguu acugagccag      840

gaggaaggcg aguacuucaa ugugccugug ccaccagaag gaagugaggc caaugaagaa      900

cugcggcaga aauuugagag ggccaagauc agucagggaa ccaagguccc ggaagaaaag      960

acgaccaaca cugucuccaa auuugacaac aauggcaaca gagaccggau gaaacugacc     1020

gauuuuaacu uccuaauggu gcuggggaaa ggcagcuuug gcaaggucau gcuuucagaa     1080

cgaaaaggca cagaugagcu cuaugcugug aagauccuga agaaggacgu ugugauccaa     1140

gaugaugacg uggagugcac uaugguggag aagcgggugu uggcccugcc ugggaagccg     1200

cccuuccuga cccagcucca cuccugcuuc cagaccaugg accgccugua cuuugugaug     1260

gaguacguga augggggcga ccucauguau cacauccagc aagucggccg guucaaggag     1320

ccccaugcug uauuuuacgc ugcagaaauu gccaucgguc uguucuucuu acagaguaag     1380

ggcaucauuu accgugaccu aaaacuugac aacgugaugc ucgauucuga gggacacauc     1440

aagauugccg auuuuggcau guguaaggaa aacaucuggg auggggugac aaccaagaca     1500

uucuguggca cuccagacua caucgccccc gagauaauug cuuaucagcc cuaugggaag     1560

uccguggauu ggugggcauu uggaguccug cuguaugaaa uguuggcugg gcaggcaccc     1620

uuugaagggg aggaugaaga ugaacucuuc caauccauca uggaacacaa cguagccuau     1680

cccaagucua uguccaagga agcuguggcc aucugcaaag ggcugaugac caaacaccca     1740

ggcaaacguc uggguugugg accugaaggc gaacgugaua ucaaagagca ugcauuuuuc     1800

cgguauauug auugggagaa acuugaacgc aaagagaucc agcccccuua uaagccaaaa     1860

gcuagagaca agagagacac cuccaacuuc gacaaagagu ucaccagaca gccuguggaa     1920

cugaccccca cugauaaacu cuucaucaug aacuuggacc aaaaugaauu ugcuggcuuc     1980

ucuuauacua acccagaguu ugucauuaau guguag                               2016


<210>  8845
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCB__Homo_sapiens__CCDS10618.1

<400>  8845
auggccgacc ccgccgcggg cccgccgccc agcgaggggg aggaguccac cgugcgcuuc       60

gcccggaagg gcgcccugcg ccagaagaac guccacgagg ugaagaacca caaguucacc      120

gcccgguucu ucaagcagcc cacguucugc agccacugca ccgacuucau cuggggguuc      180

ggcaagcagg gguuccagug ccaggugugc ugcuucgucg ugcacaagcg cugccacgag      240

uucgugaccu ucuccugccc cggcgccgac aagggccccg cgagcgacga cccccggucc      300

aagcacaagu ucaagaucca caccuacagc ucccccacgu ucugcgacca cugcgggagc      360

cuccuguacg gccugaucca ccaggggaug aagugcgaca cgugcaugau gaacguccac      420

aagcgcugcg ugaugaacgu gccgucccuc ugcggcaccg accacaccga gcggcgcggg      480

cggaucuaca uccaggccca caucgaccgc gacguccuga ucgugcuggu gcgggacgcc      540

aagaaccucg uccccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcuc      600

aucccggacc ccaaguccga gagcaagcag aagaccaaga ccaucaagug cucccugaac      660

cccgagugga acgagaccuu ccgcuuccag cugaaggaga gcgacaagga ccggcgccuc      720

uccguggaga ucugggacug ggaccugacc agccggaacg acuucauggg cucccugagc      780

uucgggaucu ccgagcucca gaaggccagc gucgacggcu gguucaagcu gcugagccag      840

gaggaggggg aguacuucaa cgugcccgug ccgcccgagg gcuccgaggc gaacgaggag      900

cuccgccaga aguucgagcg ggccaagauc agccagggca cgaagguccc cgaggagaag      960

accaccaaca ccguguccaa guucgacaac aacgggaacc gcgaccggau gaagcugacg     1020

gacuucaacu uccugauggu gcucggcaag gggagcuucg gcaaggucau gcuguccgag     1080

cgcaagggga ccgacgagcu guacgccgug aagauccuca agaaggacgu ggucauccag     1140

gacgacgacg uggagugcac cauggucgag aagcgggugc uggcccugcc cggcaagccg     1200

cccuuccuca cccagcugca cagcugcuuc cagacgaugg accgccugua cuucgugaug     1260

gaguacguca acggcgggga ccucauguac cacauccagc aggucggccg cuucaaggag     1320

ccccacgccg uguucuacgc ggccgagauc gccaucgggc uguucuuccu gcaguccaag     1380

ggcaucaucu accgggaccu caagcuggac aacgugaugc uggacagcga ggggcacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgugac caccaagacc     1500

uucugcggga cgcccgacua caucgccccg gagaucaucg cguaccagcc cuacggcaag     1560

uccguggacu ggugggccuu cgggguccuc cuguacgaga ugcuggccgg ccaggccccc     1620

uucgaggggg aggacgagga cgagcuguuc cagagcauca uggagcacaa cguggccuac     1680

cccaagucca ugagcaagga ggcgguggcc aucugcaagg gccucaugac caagcacccg     1740

ggcaagcgcc uggggugcgg ccccgagggg gagcgggaca ucaaggagca cgccuucuuc     1800

cgcuacaucg acugggagaa gcucgagcgg aaggagaucc agcccccgua caagcccaag     1860

gcccgcgaca agcgggacac cuccaacuuc gacaaggagu ucacccgcca gcccgucgag     1920

cugacgccca ccgacaagcu guucaucaug aaccucgacc agaacgaguu cgccggcuuc     1980

agcuacacca acccggaguu cgugaucaac guguga                               2016


<210>  8846
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCB__Homo_sapiens__CCDS10618.1

<400>  8846
auggccgacc ccgccgccgg cccccccccc uccgagggcg aggaguccac cguccgcuuc       60

gcccgcaagg gcgcccuccg ccagaagaac guccacgagg ucaagaacca caaguucacc      120

gcccgcuucu ucaagcagcc caccuucugc ucccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggucugc ugcuucgucg uccacaagcg cugccacgag      240

uucgucaccu ucuccugccc cggcgccgac aagggccccg ccuccgacga cccccgcucc      300

aagcacaagu ucaagaucca caccuacucc ucccccaccu ucugcgacca cugcggcucc      360

cuccucuacg gccucaucca ccagggcaug aagugcgaca ccugcaugau gaacguccac      420

aagcgcugcg ucaugaacgu ccccucccuc ugcggcaccg accacaccga gcgccgcggc      480

cgcaucuaca uccaggccca caucgaccgc gacguccuca ucguccucgu ccgcgacgcc      540

aagaaccucg uccccaugga ccccaacggc cucuccgacc ccuacgucaa gcucaagcuc      600

auccccgacc ccaaguccga guccaagcag aagaccaaga ccaucaagug cucccucaac      660

cccgagugga acgagaccuu ccgcuuccag cucaaggagu ccgacaagga ccgccgccuc      720

uccgucgaga ucugggacug ggaccucacc ucccgcaacg acuucauggg cucccucucc      780

uucggcaucu ccgagcucca gaaggccucc gucgacggcu gguucaagcu ccucucccag      840

gaggagggcg aguacuucaa cguccccguc ccccccgagg gcuccgaggc caacgaggag      900

cuccgccaga aguucgagcg cgccaagauc ucccagggca ccaagguccc cgaggagaag      960

accaccaaca ccgucuccaa guucgacaac aacggcaacc gcgaccgcau gaagcucacc     1020

gacuucaacu uccucauggu ccucggcaag ggcuccuucg gcaaggucau gcucuccgag     1080

cgcaagggca ccgacgagcu cuacgccguc aagauccuca agaaggacgu cgucauccag     1140

gacgacgacg ucgagugcac cauggucgag aagcgcgucc ucgcccuccc cggcaagccc     1200

cccuuccuca cccagcucca cuccugcuuc cagaccaugg accgccucua cuucgucaug     1260

gaguacguca acggcggcga ccucauguac cacauccagc aggucggccg cuucaaggag     1320

ccccacgccg ucuucuacgc cgccgagauc gccaucggcc ucuucuuccu ccaguccaag     1380

ggcaucaucu accgcgaccu caagcucgac aacgucaugc ucgacuccga gggccacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgucac caccaagacc     1500

uucugcggca cccccgacua caucgccccc gagaucaucg ccuaccagcc cuacggcaag     1560

uccgucgacu ggugggccuu cggcguccuc cucuacgaga ugcucgccgg ccaggccccc     1620

uucgagggcg aggacgagga cgagcucuuc caguccauca uggagcacaa cgucgccuac     1680

cccaagucca uguccaagga ggccgucgcc aucugcaagg gccucaugac caagcacccc     1740

ggcaagcgcc ucggcugcgg ccccgagggc gagcgcgaca ucaaggagca cgccuucuuc     1800

cgcuacaucg acugggagaa gcucgagcgc aaggagaucc agccccccua caagcccaag     1860

gcccgcgaca agcgcgacac cuccaacuuc gacaaggagu ucacccgcca gcccgucgag     1920

cucaccccca ccgacaagcu cuucaucaug aaccucgacc agaacgaguu cgccggcuuc     1980

uccuacacca accccgaguu cgucaucaac gucuga                               2016


<210>  8847
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCB__Homo_sapiens__CCDS10618.1

<400>  8847
auggccgacc ccgcugcagg cccuccaccg agcgaggggg aagaguccac cgugagauuc       60

gccaggaagg gagcgcugcg gcagaaaaac guccacgaag uuaagaauca uaaauuuaca      120

gcucgcuucu uuaagcaacc cacuuucugc ucucacugua cggauuuuau cugggguuuc      180

ggcaaacagg gguuucagug ccaggugugu ugcuucguag ugcauaagcg augucacgag      240

uuugucaccu ucucaugccc uggagccgac aagggcccag caagugauga cccccguagc      300

aaacauaagu uuaaaauuca cacauacucc ucuccuacuu ucugugauca cugcgguucg      360

cuccuuuaug ggcugauaca ucaaggaaug aagugugaua ccugcaugau gaacgugcac      420

aaaagaugug uuaugaaugu gccaucauug ugcggcacag accauaccga aaggcggggc      480

cgcaucuaca uucaggccca caucgacaga gaugucuuaa uugugcuggu aagggacgcu      540

aagaaccuag uucccaugga uccuaauggg cucagcgacc cauaugugaa gcugaaacuu      600

aucccggauc ccaagaguga guccaaacag aagacuaaaa caauaaagug cucucugaac      660

ccugagugga augaaaccuu ucgguuccag uugaaagaga gcgacaagga ccgccgacuc      720

uccgucgaaa ucugggauug ggaccugacg ucaagaaacg auuucauggg aagucugagc      780

uuugguauuu cugagcucca aaaggcaucc guggacggcu gguucaaauu acugucacag      840

gaggaagggg aguacuuuaa ugugccaguu cccccugaag gaagcgaggc caacgaggaa      900

cuuaggcaga aguucgagcg ggcuaaaauc agucagggca cuaagguccc agaagagaaa      960

accacaaaua cugugucuaa guuugauaac aaugguaacc gugaccgcau gaaguugacc     1020

gauuucaauu uucugauggu acuagggaaa ggauccuucg gcaaggugau gcucagcgaa     1080

agaaaaggca cagacgagcu guaugccguc aagauucuua aaaaggaugu gguuauccaa     1140

gacgaugacg uggaauguac cauggucgag aagagggugc uggcguugcc cgggaaaccg     1200

ccuuuucuca cgcagcugca cucgugcuuc cagacuaugg accgguuaua cuuuguaaug     1260

gaguauguua acggagguga ucugauguac cauauacaac aggugggccg auucaaggaa     1320

ccccacgcag ucuuuuacgc cgcugagauu gccaucggac ucuucuuccu ucagucuaaa     1380

gggauuaucu aucgcgaccu gaaguuggau aacgugaugc uagacuccga aggccauauc     1440

aaaauugcag auuuugguau guguaaggag aauauauggg acggggucac aaccaagacu     1500

uucugcggca caccagauua caucgcuccu gaaauuaucg ccuaucagcc cuacggaaaa     1560

ucaguggacu ggugggcguu uggcguucug cucuaugaga ugcuggccgg gcaagcacca     1620

uucgagggag aagaugagga cgaacuuuuu cagaguauaa uggagcacaa cguggcuuac     1680

cccaagagca uguccaaaga ggccguagcu auuuguaagg gucugaugac caaacauccu     1740

ggcaagagau uggggugcgg accagaaggc gagagggaua ucaaagaaca cgccuucuuu     1800

cgguauaucg acugggagaa gcucgaacgc aaggagauuc agccgcccua caaaccuaag     1860

gcaagagaua aaagggacac gucuaauuuc gacaaggagu uuacccguca gccagucgaa     1920

cugacaccca cugauaaauu auucaucaug aaccuggacc aaaaugaguu ugccgguuuc     1980

agcuacacca acccugaauu ugugauuaau guuuga                               2016


<210>  8848
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCB__Homo_sapiens__CCDS10618.1

<400>  8848
auggccgacc ccgccgccgg cccccccccc agcgagggcg aggagagcac cgugagauuc       60

gccagaaagg gcgcccugag acagaagaac gugcacgagg ugaagaacca caaguucacc      120

gccagauucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggugugc ugcuucgugg ugcacaagag augccacgag      240

uucgugaccu ucagcugccc cggcgccgac aagggccccg ccagcgacga ccccagaagc      300

aagcacaagu ucaagaucca caccuacagc agccccaccu ucugcgacca cugcggcagc      360

cugcuguacg gccugaucca ccagggcaug aagugcgaca ccugcaugau gaacgugcac      420

aagagaugcg ugaugaacgu gcccagccug ugcggcaccg accacaccga gagaagaggc      480

agaaucuaca uccaggccca caucgacaga gacgugcuga ucgugcuggu gagagacgcc      540

aagaaccugg ugcccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcug      600

auccccgacc ccaagagcga gagcaagcag aagaccaaga ccaucaagug cagccugaac      660

cccgagugga acgagaccuu cagauuccag cugaaggaga gcgacaagga cagaagacug      720

agcguggaga ucugggacug ggaccugacc agcagaaacg acuucauggg cagccugagc      780

uucggcauca gcgagcugca gaaggccagc guggacggcu gguucaagcu gcugagccag      840

gaggagggcg aguacuucaa cgugcccgug ccccccgagg gcagcgaggc caacgaggag      900

cugagacaga aguucgagag agccaagauc agccagggca ccaaggugcc cgaggagaag      960

accaccaaca ccgugagcaa guucgacaac aacggcaaca gagacagaau gaagcugacc     1020

gacuucaacu uccugauggu gcugggcaag ggcagcuucg gcaaggugau gcugagcgag     1080

agaaagggca ccgacgagcu guacgccgug aagauccuga agaaggacgu ggugauccag     1140

gacgacgacg uggagugcac caugguggag aagagagugc uggcccugcc cggcaagccc     1200

cccuuccuga cccagcugca cagcugcuuc cagaccaugg acagacugua cuucgugaug     1260

gaguacguga acggcggcga ccugauguac cacauccagc aggugggcag auucaaggag     1320

ccccacgccg uguucuacgc cgccgagauc gccaucggcc uguucuuccu gcagagcaag     1380

ggcaucaucu acagagaccu gaagcuggac aacgugaugc uggacagcga gggccacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgugac caccaagacc     1500

uucugcggca cccccgacua caucgccccc gagaucaucg ccuaccagcc cuacggcaag     1560

agcguggacu ggugggccuu cggcgugcug cuguacgaga ugcuggccgg ccaggccccc     1620

uucgagggcg aggacgagga cgagcuguuc cagagcauca uggagcacaa cguggccuac     1680

cccaagagca ugagcaagga ggccguggcc aucugcaagg gccugaugac caagcacccc     1740

ggcaagagac ugggcugcgg ccccgagggc gagagagaca ucaaggagca cgccuucuuc     1800

agauacaucg acugggagaa gcuggagaga aaggagaucc agccccccua caagcccaag     1860

gccagagaca agagagacac cagcaacuuc gacaaggagu ucaccagaca gcccguggag     1920

cugaccccca ccgacaagcu guucaucaug aaccuggacc agaacgaguu cgccggcuuc     1980

agcuacacca accccgaguu cgugaucaac guguga                               2016


<210>  8849
<211>  2016
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCB__Homo_sapiens__CCDS10618.1

<400>  8849
auggccgacc ccgcugccgg cccuccgccc agcgaggggg aagaguccac cgugagauuc       60

gcgcggaagg gagcucugcg ccagaaaaac guccacgaag uuaagaauca uaaauuuaca      120

gccagauucu uuaagcaacc uacguucugc ucucacugua ccgauuuuau cuggggcuuc      180

gggaaacagg gauuucagug ccaggugugu ugcuucgugg uccauaagcg gugucacgag      240

uuugugacau ucagcugccc cggcgccgac aaggggccug cuuccgauga cccccgcucu      300

aaacauaagu uuaaaauuca caccuacagc uccccuacau ucugugauca cugcggaucu      360

cuccuguaug gccuuaucca ucaaggcaug aagugugaua ccugcaugau gaacguucac      420

aaaagaugug ugaugaaugu cccgagccug ugcgggacag accauaccga acggcgcgga      480

agaauuuaca uccaggccca cauugaccgg gaugugcuca ucguucuggu gcgcgacgcu      540

aagaaccuug uccccaugga uccuaauggc cuguccgacc ccuaugugaa gcucaaacug      600

aucccugauc ccaagagcga gucuaaacag aagacgaaaa ccauuaagug cucccugaac      660

ccggagugga augaaacauu uagauuccag cucaaagaga gcgacaagga ccggcgccug      720

ucuguggaaa ucugggauug ggaccuuacc uccagaaacg auuucauggg gagccugucu      780

uuuggaauuu ccgagcucca aaaggccagc gucgacggcu gguucaaacu gcuuucccag      840

gaggaagggg aguacuuuaa uguuccugug cccccugaag gaucugaggc gaacgaggaa      900

cugcggcaga aguucgagcg cgccaaaauc agccagggca caaaggugcc cgaagagaaa      960

accacgaaua cagucuccaa guuugauaac aauggcaaca gagaccggau gaagcucacc     1020

gauuucaauu uucugauggu gcuggggaaa ggcagcuucg gaaagguuau gcucucugaa     1080

agaaaaggga cagacgagcu guaugcugug aagauucuua aaaaggaugu cgugauccaa     1140

gacgaugacg uugaauguac caugguggag aagcgcgucc uggcccuccc cggaaaaccu     1200

ccguuucuga cccagcuuca cuccugcuuc cagacaaugg accggcugua cuuugugaug     1260

gaguauguca acggcgggga ucucauguac cauauucaac aggugggaag auucaaggaa     1320

ccccacgcug uguuuuacgc cgcggagauc gccaucggcc uguucuuccu gcagagcaaa     1380

ggcauuaucu aucgcgaccu caagcuggau aacguuaugc uugacucuga agggcauauu     1440

aaaaucgcug auuuuggaau guguaaggag aauauuuggg acggcgucac gaccaagaca     1500

uucugcggga ccccugauua caucgccccc gaaaucauug cuuaucagcc uuacggaaaa     1560

agcguggacu ggugggccuu uggcguucug cucuaugaga ugcuggccgg gcaagcuccc     1620

uucgagggcg aagaugagga cgaacuuuuu caguccauca uggagcacaa cguggcguac     1680

ccgaagucua ugagcaaaga ggccgucgcu auuuguaagg gacugaugac aaaacauccu     1740

ggcaagcggc ucgggugcgg acccgaaggc gagagagaua ucaaagaaca cgccuucuuu     1800

cgcuauauug acugggagaa gcuggaacgg aaggagaucc agccucccua caaaccuaag     1860

gccagagaua aacgcgacac cuccaauuuc gacaaggagu uuacgcggca gcccguggaa     1920

cugacaccga ccgauaaacu cuucaucaug aaccuggacc aaaaugaguu ugcuggguuc     1980

agcuacacca acccugaauu ugugauuaau guuuga                               2016


<210>  8850
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCB__Homo_sapiens__P05771-2

<400>  8850

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser 
    


<210>  8851
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCB__Homo_sapiens__CCDS10619.1

<400>  8851
auggcugacc cggcugcggg gccgccgccg agcgagggcg aggagagcac cgugcgcuuc       60

gcccgcaaag gcgcccuccg gcagaagaac gugcaugagg ucaagaacca caaauucacc      120

gcccgcuucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggcuuc      180

gggaagcagg gauuccagug ccaaguuugc ugcuuugugg ugcacaagcg gugccaugaa      240

uuugucacau ucuccugccc uggcgcugac aaggguccag ccuccgauga cccccgcagc      300

aaacacaagu uuaagaucca cacguacucc agccccacgu uuugugacca cuguggguca      360

cugcuguaug gacucaucca ccaggggaug aaaugugaca ccugcaugau gaaugugcac      420

aagcgcugcg ugaugaaugu ucccagccug uguggcacgg accacacgga gcgccgcggc      480

cgcaucuaca uccaggccca caucgacagg gacguccuca uuguccucgu aagagaugcu      540

aaaaaccuug uaccuaugga ccccaauggc cugucagauc ccuacguaaa acugaaacug      600

auucccgauc ccaaaaguga gagcaaacag aagaccaaaa ccaucaaaug cucccucaac      660

ccugagugga augagacauu uagauuucag cugaaagaau cggacaaaga cagaagacug      720

ucaguagaga uuugggauug ggauuugacc agcaggaaug acuucauggg aucuuugucc      780

uuugggauuu cugaacuuca gaaagccagu guugauggcu gguuuaaguu acugagccag      840

gaggaaggcg aguacuucaa ugugccugug ccaccagaag gaagugaggc caaugaagaa      900

cugcggcaga aauuugagag ggccaagauc agucagggaa ccaagguccc ggaagaaaag      960

acgaccaaca cugucuccaa auuugacaac aauggcaaca gagaccggau gaaacugacc     1020

gauuuuaacu uccuaauggu gcuggggaaa ggcagcuuug gcaaggucau gcuuucagaa     1080

cgaaaaggca cagaugagcu cuaugcugug aagauccuga agaaggacgu ugugauccaa     1140

gaugaugacg uggagugcac uaugguggag aagcgggugu uggcccugcc ugggaagccg     1200

cccuuccuga cccagcucca cuccugcuuc cagaccaugg accgccugua cuuugugaug     1260

gaguacguga augggggcga ccucauguau cacauccagc aagucggccg guucaaggag     1320

ccccaugcug uauuuuacgc ugcagaaauu gccaucgguc uguucuucuu acagaguaag     1380

ggcaucauuu accgugaccu aaaacuugac aacgugaugc ucgauucuga gggacacauc     1440

aagauugccg auuuuggcau guguaaggaa aacaucuggg auggggugac aaccaagaca     1500

uucuguggca cuccagacua caucgccccc gagauaauug cuuaucagcc cuaugggaag     1560

uccguggauu ggugggcauu uggaguccug cuguaugaaa uguuggcugg gcaggcaccc     1620

uuugaagggg aggaugaaga ugaacucuuc caauccauca uggaacacaa cguagccuau     1680

cccaagucua uguccaagga agcuguggcc aucugcaaag ggcugaugac caaacaccca     1740

ggcaaacguc uggguugugg accugaaggc gaacgugaua ucaaagagca ugcauuuuuc     1800

cgguauauug auugggagaa acuugaacgc aaagagaucc agcccccuua uaagccaaaa     1860

gcuugugggc gaaaugcuga aaacuucgac cgauuuuuca cccgccaucc accaguccua     1920

acaccucccg accaggaagu caucaggaau auugaccaau cagaauucga aggauuuucc     1980

uuuguuaacu cugaauuuuu aaaacccgaa gucaagagcu aa                        2022


<210>  8852
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCB__Homo_sapiens__CCDS10619.1

<400>  8852
auggccgacc ccgccgcggg gcccccgccc agcgagggcg aggaguccac cgugcgcuuc       60

gcccggaagg gcgcccugcg ccagaagaac guccacgagg ugaagaacca caaguucacc      120

gcccgguucu ucaagcagcc cacguucugc agccacugca ccgacuucau cuggggguuc      180

ggcaagcagg gguuccagug ccaggugugc ugcuucgucg ugcacaagcg cugccacgag      240

uucgugaccu ucuccugccc cggcgccgac aagggccccg cgagcgacga cccccggucc      300

aagcacaagu ucaagaucca caccuacagc ucccccacgu ucugcgacca cugcgggagc      360

cuccuguacg gccugaucca ccaggggaug aagugcgaca cgugcaugau gaacguccac      420

aagcgcugcg ugaugaacgu gccgucccuc ugcggcaccg accacaccga gcggcgcggg      480

cggaucuaca uccaggccca caucgaccgc gacguccuga ucgugcuggu gcgggacgcc      540

aagaaccucg uccccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcuc      600

aucccggacc ccaaguccga gagcaagcag aagaccaaga ccaucaagug cucccugaac      660

cccgagugga acgagaccuu ccgcuuccag cugaaggaga gcgacaagga ccggcgccuc      720

uccguggaga ucugggacug ggaccugacc agccggaacg acuucauggg cucccugagc      780

uucgggaucu ccgagcucca gaaggccagc gucgacggcu gguucaagcu gcugagccag      840

gaggaggggg aguacuucaa cgugcccgug ccgcccgagg gcuccgaggc gaacgaggag      900

cuccgccaga aguucgagcg ggccaagauc agccagggca cgaagguccc cgaggagaag      960

accaccaaca ccguguccaa guucgacaac aacgggaacc gcgaccggau gaagcugacg     1020

gacuucaacu uccugauggu gcucggcaag gggagcuucg gcaaggucau gcuguccgag     1080

cgcaagggga ccgacgagcu guacgccgug aagauccuca agaaggacgu ggucauccag     1140

gacgacgacg uggagugcac cauggucgag aagcgggugc uggcccugcc cggcaagccg     1200

cccuuccuca cccagcugca cagcugcuuc cagacgaugg accgccugua cuucgugaug     1260

gaguacguca acggcgggga ccucauguac cacauccagc aggucggccg cuucaaggag     1320

ccccacgccg uguucuacgc ggccgagauc gccaucgggc uguucuuccu gcaguccaag     1380

ggcaucaucu accgggaccu caagcuggac aacgugaugc uggacagcga ggggcacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgugac caccaagacc     1500

uucugcggga cgcccgacua caucgccccg gagaucaucg cguaccagcc cuacggcaag     1560

uccguggacu ggugggccuu cgggguccuc cuguacgaga ugcuggccgg ccaggccccc     1620

uucgaggggg aggacgagga cgagcuguuc cagagcauca uggagcacaa cguggccuac     1680

cccaagucca ugagcaagga ggcgguggcc aucugcaagg gccucaugac caagcacccg     1740

ggcaagcgcc uggggugcgg ccccgagggg gagcgggaca ucaaggagca cgccuucuuc     1800

cgcuacaucg acugggagaa gcucgagcgg aaggagaucc agcccccgua caagcccaag     1860

gccugcggcc gcaacgccga gaacuucgac cgguucuuca cccgccaccc gcccguccug     1920

accccgcccg accaggaggu gauccggaac aucgaccagu ccgaguucga gggcuucagc     1980

uucgugaacu ccgaguuccu gaagcccgag gucaagagcu ga                        2022


<210>  8853
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCB__Homo_sapiens__CCDS10619.1

<400>  8853
auggccgacc ccgccgccgg cccccccccc uccgagggcg aggaguccac cguccgcuuc       60

gcccgcaagg gcgcccuccg ccagaagaac guccacgagg ucaagaacca caaguucacc      120

gcccgcuucu ucaagcagcc caccuucugc ucccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggucugc ugcuucgucg uccacaagcg cugccacgag      240

uucgucaccu ucuccugccc cggcgccgac aagggccccg ccuccgacga cccccgcucc      300

aagcacaagu ucaagaucca caccuacucc ucccccaccu ucugcgacca cugcggcucc      360

cuccucuacg gccucaucca ccagggcaug aagugcgaca ccugcaugau gaacguccac      420

aagcgcugcg ucaugaacgu ccccucccuc ugcggcaccg accacaccga gcgccgcggc      480

cgcaucuaca uccaggccca caucgaccgc gacguccuca ucguccucgu ccgcgacgcc      540

aagaaccucg uccccaugga ccccaacggc cucuccgacc ccuacgucaa gcucaagcuc      600

auccccgacc ccaaguccga guccaagcag aagaccaaga ccaucaagug cucccucaac      660

cccgagugga acgagaccuu ccgcuuccag cucaaggagu ccgacaagga ccgccgccuc      720

uccgucgaga ucugggacug ggaccucacc ucccgcaacg acuucauggg cucccucucc      780

uucggcaucu ccgagcucca gaaggccucc gucgacggcu gguucaagcu ccucucccag      840

gaggagggcg aguacuucaa cguccccguc ccccccgagg gcuccgaggc caacgaggag      900

cuccgccaga aguucgagcg cgccaagauc ucccagggca ccaagguccc cgaggagaag      960

accaccaaca ccgucuccaa guucgacaac aacggcaacc gcgaccgcau gaagcucacc     1020

gacuucaacu uccucauggu ccucggcaag ggcuccuucg gcaaggucau gcucuccgag     1080

cgcaagggca ccgacgagcu cuacgccguc aagauccuca agaaggacgu cgucauccag     1140

gacgacgacg ucgagugcac cauggucgag aagcgcgucc ucgcccuccc cggcaagccc     1200

cccuuccuca cccagcucca cuccugcuuc cagaccaugg accgccucua cuucgucaug     1260

gaguacguca acggcggcga ccucauguac cacauccagc aggucggccg cuucaaggag     1320

ccccacgccg ucuucuacgc cgccgagauc gccaucggcc ucuucuuccu ccaguccaag     1380

ggcaucaucu accgcgaccu caagcucgac aacgucaugc ucgacuccga gggccacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgucac caccaagacc     1500

uucugcggca cccccgacua caucgccccc gagaucaucg ccuaccagcc cuacggcaag     1560

uccgucgacu ggugggccuu cggcguccuc cucuacgaga ugcucgccgg ccaggccccc     1620

uucgagggcg aggacgagga cgagcucuuc caguccauca uggagcacaa cgucgccuac     1680

cccaagucca uguccaagga ggccgucgcc aucugcaagg gccucaugac caagcacccc     1740

ggcaagcgcc ucggcugcgg ccccgagggc gagcgcgaca ucaaggagca cgccuucuuc     1800

cgcuacaucg acugggagaa gcucgagcgc aaggagaucc agccccccua caagcccaag     1860

gccugcggcc gcaacgccga gaacuucgac cgcuucuuca cccgccaccc ccccguccuc     1920

accccccccg accaggaggu cauccgcaac aucgaccagu ccgaguucga gggcuucucc     1980

uucgucaacu ccgaguuccu caagcccgag gucaaguccu ga                        2022


<210>  8854
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCB__Homo_sapiens__CCDS10619.1

<400>  8854
auggccgacc ccgcugcagg cccuccaccg agcgaggggg aagaguccac cgugagauuc       60

gccaggaagg gagcgcugcg gcagaaaaac guccacgaag uuaagaauca uaaauuuaca      120

gcucgcuucu uuaagcaacc cacuuucugc ucucacugua cggauuuuau cugggguuuc      180

ggcaaacagg gguuucagug ccaggugugu ugcuucguag ugcauaagcg augucacgag      240

uuugucaccu ucucaugccc uggagccgac aagggcccag caagugauga cccccguagc      300

aaacauaagu uuaaaauuca cacauacucc ucuccuacuu ucugugauca cugcgguucg      360

cuccuuuaug ggcugauaca ucaaggaaug aagugugaua ccugcaugau gaacgugcac      420

aaaagaugug uuaugaaugu gccaucauug ugcggcacag accauaccga aaggcggggc      480

cgcaucuaca uucaggccca caucgacaga gaugucuuaa uugugcuggu aagggacgcu      540

aagaaccuag uucccaugga uccuaauggg cucagcgacc cauaugugaa gcugaaacuu      600

aucccggauc ccaagaguga guccaaacag aagacuaaaa caauaaagug cucucugaac      660

ccugagugga augaaaccuu ucgguuccag uugaaagaga gcgacaagga ccgccgacuc      720

uccgucgaaa ucugggauug ggaccugacg ucaagaaacg auuucauggg aagucugagc      780

uuugguauuu cugagcucca aaaggcaucc guggacggcu gguucaaauu acugucacag      840

gaggaagggg aguacuuuaa ugugccaguu cccccugaag gaagcgaggc caacgaggaa      900

cuuaggcaga aguucgagcg ggcuaaaauc agucagggca cuaagguccc agaagagaaa      960

accacaaaua cugugucuaa guuugauaac aaugguaacc gugaccgcau gaaguugacc     1020

gauuucaauu uucugauggu acuagggaaa ggauccuucg gcaaggugau gcucagcgaa     1080

agaaaaggca cagacgagcu guaugccguc aagauucuua aaaaggaugu gguuauccaa     1140

gacgaugacg uggaauguac cauggucgag aagagggugc uggcguugcc cgggaaaccg     1200

ccuuuucuca cgcagcugca cucgugcuuc cagacuaugg accgguuaua cuuuguaaug     1260

gaguauguua acggagguga ucugauguac cauauacaac aggugggccg auucaaggaa     1320

ccccacgcag ucuuuuacgc cgcugagauu gccaucggac ucuucuuccu ucagucuaaa     1380

gggauuaucu aucgcgaccu gaaguuggau aacgugaugc uagacuccga aggccauauc     1440

aaaauugcag auuuugguau guguaaggag aauauauggg acggggucac aaccaagacu     1500

uucugcggca caccagauua caucgcuccu gaaauuaucg ccuaucagcc cuacggaaaa     1560

ucaguggacu ggugggcguu uggcguucug cucuaugaga ugcuggccgg gcaagcacca     1620

uucgagggag aagaugagga cgaacuuuuu cagaguauaa uggagcacaa cguggcuuac     1680

cccaagagca uguccaaaga ggccguagcu auuuguaagg gucugaugac caaacauccu     1740

ggcaagagau uggggugcgg accagaaggc gagagggaua ucaaagaaca cgccuucuuu     1800

cgguauaucg acugggagaa gcucgaacgc aaggagauuc agccgcccua caaaccuaag     1860

gcauguggua gaaaugccga gaacuucgau agguuuuuca cgcgucaccc acccguccug     1920

accccuccag accaggaagu gauccggaau auugaccaau cugaguuuga aggguucagc     1980

uuuguuaacu cagaguucuu aaaacccgaa gugaagaguu ga                        2022


<210>  8855
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCB__Homo_sapiens__CCDS10619.1

<400>  8855
auggccgacc ccgccgccgg cccccccccc agcgagggcg aggagagcac cgugagauuc       60

gccagaaagg gcgcccugag acagaagaac gugcacgagg ugaagaacca caaguucacc      120

gccagauucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggugugc ugcuucgugg ugcacaagag augccacgag      240

uucgugaccu ucagcugccc cggcgccgac aagggccccg ccagcgacga ccccagaagc      300

aagcacaagu ucaagaucca caccuacagc agccccaccu ucugcgacca cugcggcagc      360

cugcuguacg gccugaucca ccagggcaug aagugcgaca ccugcaugau gaacgugcac      420

aagagaugcg ugaugaacgu gcccagccug ugcggcaccg accacaccga gagaagaggc      480

agaaucuaca uccaggccca caucgacaga gacgugcuga ucgugcuggu gagagacgcc      540

aagaaccugg ugcccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcug      600

auccccgacc ccaagagcga gagcaagcag aagaccaaga ccaucaagug cagccugaac      660

cccgagugga acgagaccuu cagauuccag cugaaggaga gcgacaagga cagaagacug      720

agcguggaga ucugggacug ggaccugacc agcagaaacg acuucauggg cagccugagc      780

uucggcauca gcgagcugca gaaggccagc guggacggcu gguucaagcu gcugagccag      840

gaggagggcg aguacuucaa cgugcccgug ccccccgagg gcagcgaggc caacgaggag      900

cugagacaga aguucgagag agccaagauc agccagggca ccaaggugcc cgaggagaag      960

accaccaaca ccgugagcaa guucgacaac aacggcaaca gagacagaau gaagcugacc     1020

gacuucaacu uccugauggu gcugggcaag ggcagcuucg gcaaggugau gcugagcgag     1080

agaaagggca ccgacgagcu guacgccgug aagauccuga agaaggacgu ggugauccag     1140

gacgacgacg uggagugcac caugguggag aagagagugc uggcccugcc cggcaagccc     1200

cccuuccuga cccagcugca cagcugcuuc cagaccaugg acagacugua cuucgugaug     1260

gaguacguga acggcggcga ccugauguac cacauccagc aggugggcag auucaaggag     1320

ccccacgccg uguucuacgc cgccgagauc gccaucggcc uguucuuccu gcagagcaag     1380

ggcaucaucu acagagaccu gaagcuggac aacgugaugc uggacagcga gggccacauc     1440

aagaucgccg acuucggcau gugcaaggag aacaucuggg acggcgugac caccaagacc     1500

uucugcggca cccccgacua caucgccccc gagaucaucg ccuaccagcc cuacggcaag     1560

agcguggacu ggugggccuu cggcgugcug cuguacgaga ugcuggccgg ccaggccccc     1620

uucgagggcg aggacgagga cgagcuguuc cagagcauca uggagcacaa cguggccuac     1680

cccaagagca ugagcaagga ggccguggcc aucugcaagg gccugaugac caagcacccc     1740

ggcaagagac ugggcugcgg ccccgagggc gagagagaca ucaaggagca cgccuucuuc     1800

agauacaucg acugggagaa gcuggagaga aaggagaucc agccccccua caagcccaag     1860

gccugcggca gaaacgccga gaacuucgac agauucuuca ccagacaccc ccccgugcug     1920

accccccccg accaggaggu gaucagaaac aucgaccaga gcgaguucga gggcuucagc     1980

uucgugaaca gcgaguuccu gaagcccgag gugaagagcu ga                        2022


<210>  8856
<211>  2022
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCB__Homo_sapiens__CCDS10619.1

<400>  8856
auggccgacc ccgcugccgg cccuccgccc agcgaggggg aagaguccac cgugagauuc       60

gcgcggaagg gagcucugcg ccagaaaaac guccacgaag uuaagaauca caaauuuaca      120

gccagauucu uuaagcaacc uacguucugc ucucacugua ccgauuuuau cuggggcuuc      180

gggaaacagg gauuucagug ccaggugugu ugcuucgugg uccauaagcg gugucacgag      240

uuugugacau ucagcugccc cggcgccgac aaggggccug cuuccgauga cccccgcucu      300

aaacauaagu uuaaaauuca caccuacagc uccccuacau ucugugauca cugcggaucu      360

cuccuguaug gccuuaucca ucaaggcaug aagugugaua ccugcaugau gaacguucac      420

aaaagaugug ugaugaaugu cccgagccug ugcgggacag accauaccga acggcgcgga      480

agaauuuaca uccaggccca cauugaccgg gaugugcuca ucguucuggu gcgcgacgcu      540

aagaaccuug uccccaugga uccuaauggc cuguccgacc ccuaugugaa gcucaaacug      600

aucccugauc ccaagagcga gucuaaacag aagacgaaaa ccauuaagug cucccugaac      660

ccggagugga augaaacauu uagauuccag cucaaagaga gcgacaagga ccggcgccug      720

ucuguggaaa ucugggauug ggaccuuacc uccagaaacg auuucauggg gagccugucu      780

uuuggaauuu ccgagcucca aaaggccagc gucgacggcu gguucaaacu gcuuucccag      840

gaggaagggg aguacuuuaa uguuccugug cccccugaag gaucugaggc gaacgaggaa      900

cugcggcaga aguucgagcg cgccaaaauc agccagggca caaaggugcc cgaagagaaa      960

accacgaaua cagucuccaa guuugauaac aauggcaaca gagaccggau gaagcucacc     1020

gauuucaauu uucugauggu gcuggggaaa ggcagcuucg gaaagguuau gcucucugaa     1080

agaaaaggga cagacgagcu guaugcugug aagauucuua aaaaggaugu cgugauccaa     1140

gacgaugacg uugaauguac caugguggag aagcgcgucc uggcccuccc cggaaaaccu     1200

ccguuucuga cccagcuuca cuccugcuuc cagacaaugg accggcugua cuuugugaug     1260

gaguauguca acggcgggga ucucauguac cauauucaac aggugggaag auucaaggaa     1320

ccccacgcug uguuuuacgc cgcggagauc gccaucggcc uguucuuccu gcagagcaaa     1380

ggcauuaucu aucgcgaccu caagcuggau aacguuaugc uugacucuga agggcauauu     1440

aaaaucgcug auuuuggaau guguaaggag aauauuuggg acggcgucac gaccaagaca     1500

uucugcggga ccccugauua caucgccccc gaaaucauug cuuaucagcc uuacggaaaa     1560

agcguggacu ggugggccuu uggcguucug cucuaugaga ugcuggccgg gcaagcuccc     1620

uucgagggcg aagaugagga cgaacuuuuu caguccauca uggagcacaa cguggcguac     1680

ccgaagucua ugagcaaaga ggccgucgcu auuuguaagg gacugaugac aaaacauccu     1740

ggcaagcggc ucgggugcgg acccgaaggc gagagagaua ucaaagaaca cgccuucuuu     1800

cgcuauauug acugggagaa gcuggaacgg aaggagaucc agccucccua caaaccuaag     1860

gccuguggga gaaaugcuga gaacuucgau cgcuuuuuca cccggcaucc cccggugcug     1920

acgccucccg accaggaagu gaucagaaau auugaccaau ccgaguuuga aggauucagc     1980

uuuguuaacu cugaguuccu caaacccgaa gucaaguccu ga                        2022


<210>  8857
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCD1__Homo_sapiens__Q15139

<400>  8857

Met Ser Ala Pro Pro Val Leu Arg Pro Pro Ser Pro Leu Leu Pro Val 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Val Pro Gly Ser Gly 
            20                  25                  30          


Pro Gly Pro Ala Pro Phe Leu Ala Pro Val Ala Ala Pro Val Gly Gly 
        35                  40                  45              


Ile Ser Phe His Leu Gln Ile Gly Leu Ser Arg Glu Pro Val Leu Leu 
    50                  55                  60                  


Leu Gln Asp Ser Ser Gly Asp Tyr Ser Leu Ala His Val Arg Glu Met 
65                  70                  75                  80  


Ala Cys Ser Ile Val Asp Gln Lys Phe Pro Glu Cys Gly Phe Tyr Gly 
                85                  90                  95      


Met Tyr Asp Lys Ile Leu Leu Phe Arg His Asp Pro Thr Ser Glu Asn 
            100                 105                 110         


Ile Leu Gln Leu Val Lys Ala Ala Ser Asp Ile Gln Glu Gly Asp Leu 
        115                 120                 125             


Ile Glu Val Val Leu Ser Ala Ser Ala Thr Phe Glu Asp Phe Gln Ile 
    130                 135                 140                 


Arg Pro His Ala Leu Phe Val His Ser Tyr Arg Ala Pro Ala Phe Cys 
145                 150                 155                 160 


Asp His Cys Gly Glu Met Leu Trp Gly Leu Val Arg Gln Gly Leu Lys 
                165                 170                 175     


Cys Glu Gly Cys Gly Leu Asn Tyr His Lys Arg Cys Ala Phe Lys Ile 
            180                 185                 190         


Pro Asn Asn Cys Ser Gly Val Arg Arg Arg Arg Leu Ser Asn Val Ser 
        195                 200                 205             


Leu Thr Gly Val Ser Thr Ile Arg Thr Ser Ser Ala Glu Leu Ser Thr 
    210                 215                 220                 


Ser Ala Pro Asp Glu Pro Leu Leu Gln Lys Ser Pro Ser Glu Ser Phe 
225                 230                 235                 240 


Ile Gly Arg Glu Lys Arg Ser Asn Ser Gln Ser Tyr Ile Gly Arg Pro 
                245                 250                 255     


Ile His Leu Asp Lys Ile Leu Met Ser Lys Val Lys Val Pro His Thr 
            260                 265                 270         


Phe Val Ile His Ser Tyr Thr Arg Pro Thr Val Cys Gln Tyr Cys Lys 
        275                 280                 285             


Lys Leu Leu Lys Gly Leu Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys 
    290                 295                 300                 


Arg Phe Asn Cys His Lys Arg Cys Ala Pro Lys Val Pro Asn Asn Cys 
305                 310                 315                 320 


Leu Gly Glu Val Thr Ile Asn Gly Asp Leu Leu Ser Pro Gly Ala Glu 
                325                 330                 335     


Ser Asp Val Val Met Glu Glu Gly Ser Asp Asp Asn Asp Ser Glu Arg 
            340                 345                 350         


Asn Ser Gly Leu Met Asp Asp Met Glu Glu Ala Met Val Gln Asp Ala 
        355                 360                 365             


Glu Met Ala Met Ala Glu Cys Gln Asn Asp Ser Gly Glu Met Gln Asp 
    370                 375                 380                 


Pro Asp Pro Asp His Glu Asp Ala Asn Arg Thr Ile Ser Pro Ser Thr 
385                 390                 395                 400 


Ser Asn Asn Ile Pro Leu Met Arg Val Val Gln Ser Val Lys His Thr 
                405                 410                 415     


Lys Arg Lys Ser Ser Thr Val Met Lys Glu Gly Trp Met Val His Tyr 
            420                 425                 430         


Thr Ser Lys Asp Thr Leu Arg Lys Arg His Tyr Trp Arg Leu Asp Ser 
        435                 440                 445             


Lys Cys Ile Thr Leu Phe Gln Asn Asp Thr Gly Ser Arg Tyr Tyr Lys 
    450                 455                 460                 


Glu Ile Pro Leu Ser Glu Ile Leu Ser Leu Glu Pro Val Lys Thr Ser 
465                 470                 475                 480 


Ala Leu Ile Pro Asn Gly Ala Asn Pro His Cys Phe Glu Ile Thr Thr 
                485                 490                 495     


Ala Asn Val Val Tyr Tyr Val Gly Glu Asn Val Val Asn Pro Ser Ser 
            500                 505                 510         


Pro Ser Pro Asn Asn Ser Val Leu Thr Ser Gly Val Gly Ala Asp Val 
        515                 520                 525             


Ala Arg Met Trp Glu Ile Ala Ile Gln His Ala Leu Met Pro Val Ile 
    530                 535                 540                 


Pro Lys Gly Ser Ser Val Gly Thr Gly Thr Asn Leu His Arg Asp Ile 
545                 550                 555                 560 


Ser Val Ser Ile Ser Val Ser Asn Cys Gln Ile Gln Glu Asn Val Asp 
                565                 570                 575     


Ile Ser Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
            580                 585                 590         


Gln Phe Gly Ile Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
        595                 600                 605             


Val Ala Ile Lys Ile Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
    610                 615                 620                 


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Asn Leu His His Pro 
625                 630                 635                 640 


Gly Val Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Arg Val Phe 
                645                 650                 655     


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
            660                 665                 670         


Ser Glu Lys Gly Arg Leu Pro Glu His Ile Thr Lys Phe Leu Ile Thr 
        675                 680                 685             


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
    690                 695                 700                 


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
705                 710                 715                 720 


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
                725                 730                 735     


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
            740                 745                 750         


Glu Val Leu Arg Asn Lys Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
        755                 760                 765             


Val Gly Val Ile Ile Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
    770                 775                 780                 


Glu Asp Glu Asp Ile His Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
785                 790                 795                 800 


Pro Pro Asn Pro Trp Lys Glu Ile Ser His Glu Ala Ile Asp Leu Ile 
                805                 810                 815     


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
            820                 825                 830         


Thr Leu Ser His Pro Trp Leu Gln Asp Tyr Gln Thr Trp Leu Asp Leu 
        835                 840                 845             


Arg Glu Leu Glu Cys Lys Ile Gly Glu Arg Tyr Ile Thr His Glu Ser 
    850                 855                 860                 


Asp Asp Leu Arg Trp Glu Lys Tyr Ala Gly Glu Gln Gly Leu Gln Tyr 
865                 870                 875                 880 


Pro Thr His Leu Ile Asn Pro Ser Ala Ser His Ser Asp Thr Pro Glu 
                885                 890                 895     


Thr Glu Glu Thr Glu Met Lys Ala Leu Gly Glu Arg Val Ser Ile Leu 
            900                 905                 910         






<210>  8858
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCD1__Homo_sapiens__BAG36853

<400>  8858
augagcgccc cuccgguccu gcggccgccc aguccgcugc ugcccguggc ggcggcagcu       60

gccgcagcgg ccgccgcacu ggucccaggg uccgggcccg ggcccgcgcc guucuuggcu      120

ccugucgcgg ccccggucgg gggcaucucg uuccaucugc agaucggccu gagccgugag      180

ccggugcugc ugcugcagga cucguccggg gacuacagcc uggcgcacgu ccgcgagaug      240

gcuugcucca uugucgacca gaaguucccu gaaugugguu ucuacggaau guaugauaag      300

auccugcuuu uucgccauga cccuaccucu gaaaacaucc uucagcuggu gaaagcggcc      360

agugauaucc aggaaggcga ucuuauugaa guggucuugu cagcuuccgc caccuuugaa      420

gacuuucaga uucgucccca cgcucucuuu guucauucau acagagcucc agcuuucugu      480

gaucacugug gagaaaugcu gugggggcug guacgucaag gucuuaaaug ugaagggugu      540

ggucugaauu accauaagag augugcauuu aaaauaccca acaauugcag cggugugagg      600

cggagaaggc ucucaaacgu uucccucacu ggggucagca ccauccgcac aucaucugcu      660

gaacucucua caagugcccc ugaugagccc cuucugcaaa aaucaccauc agagucguuu      720

auuggucgag agaagagguc aaauucucaa ucauacauug gacgaccaau ucaccuugac      780

aagauuuuga ugucuaaagu uaaagugccg cacacauuug ucauccacuc cuacacccgg      840

cccacagugu gccaguacug caagaagcuu cugaaggggc uuuucaggca gggcuugcag      900

ugcaaagauu gcagauucaa cugccauaaa cguugugcac cgaaaguacc aaacaacugc      960

cuuggcgaag ugaccauuaa uggagauuug cuuagcccug gggcagaguc ugaugugguc     1020

auggaagaag ggagugauga caaugauagu gaaaggaaca gugggcucau ggaugauaug     1080

gaagaagcaa ugguccaaga ugcagagaug gcaauggcag agugccagaa cgacaguggc     1140

gagaugcaag auccagaccc agaccacgag gacgccaaca gaaccaucag uccaucaaca     1200

agcaacaaua ucccacucau gaggguagug cagucuguca aacacacgaa gaggaaaagc     1260

agcacaguca ugaaagaagg auggaugguc cacuacacca gcaaggacac gcugcggaaa     1320

cggcacuauu ggagauugga uagcaaaugu auuacccucu uucagaauga cacaggaagc     1380

agguacuaca aggaaauucc uuuaucugaa auuuugucuc uggaaccagu aaaaacuuca     1440

gcuuuaauuc cuaauggggc caauccucau uguuucgaaa ucacuacggc aaauguagug     1500

uauuaugugg gagaaaaugu ggucaauccu uccagcccau caccaaauaa caguguucuc     1560

accaguggcg uuggugcaga uguggccagg augugggaga uagccaucca gcaugcccuu     1620

augcccguca uucccaaggg cuccuccgug gguacaggaa ccaacuugca cagagauauc     1680

ucugugagua uuucaguauc aaauugccag auucaagaaa auguggacau cagcacagua     1740

uaucagauuu uuccugauga aguacugggu ucuggacagu uuggaauugu uuauggagga     1800

aaacaucgua aaacaggaag agauguagcu auuaaaauca uugacaaauu acgauuucca     1860

acaaaacaag aaagccagcu ucguaaugag guugcaauuc uacagaaccu ucaucacccu     1920

gguguuguaa auuuggagug uauguuugag acgccugaaa gaguguuugu uguuauggaa     1980

aaacuccaug gagacaugcu ggaaaugauc uugucaagug aaaagggcag guugccagag     2040

cacauaacga aguuuuuaau uacucagaua cucguggcuu ugcggcaccu ucauuuuaaa     2100

aauaucguuc acugugaccu caaaccagaa aauguguugc uagccucagc ugauccuuuu     2160

ccucagguga aacuuuguga uuuugguuuu gcccggauca uuggagagaa gucuuuccgg     2220

aggucagugg uggguacccc cgcuuaccug gcuccugagg uccuaaggaa caagggcuac     2280

aaucgcucuc uagacaugug gucuguuggg gucaucaucu auguaagccu aagcggcaca     2340

uucccauuua augaagauga agacauacac gaccaaauuc agaaugcagc uuucauguau     2400

ccaccaaauc ccuggaagga aauaucucau gaagccauug aucuuaucaa caauuugcug     2460

caaguaaaaa ugagaaagcg cuacagugug gauaagaccu ugagccaccc uuggcuacag     2520

gacuaucaga ccugguuaga uuugcgagag cuggaaugca aaaucgggga gcgcuacauc     2580

acccaugaaa gugaugaccu gaggugggag aaguaugcag gcgagcaggg gcugcaguac     2640

cccacacacc ugaucaaucc aagugcuagc cacagugaca cuccugagac ugaagaaaca     2700

gaaaugaaag cccucgguga gcgugucagc auccucuga                            2739


<210>  8859
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCD1__Homo_sapiens__BAG36853

<400>  8859
augagcgcgc ccccggugcu gcgcccgccc agcccccucc ugcccgucgc cgccgccgcc       60

gccgccgcgg ccgccgcccu ggugcccggc agcgggcccg gccccgcgcc guuccucgcc      120

cccguggccg cccccgucgg gggcaucucc uuccaccucc agaucgggcu gagccgggag      180

cccgugcugc ugcugcagga cuccagcggc gacuacuccc ucgcccacgu gcgcgagaug      240

gcgugcagca ucgucgacca gaaguucccg gagugcggcu ucuacgggau guacgacaag      300

auccugcugu uccggcacga ccccaccucc gagaacaucc uccagcuggu gaaggccgcc      360

agcgacaucc aggagggcga ccugaucgag gugguccucu ccgccagcgc caccuucgag      420

gacuuccaga uccgccccca cgcgcuguuc gugcacuccu accgggcccc cgccuucugc      480

gaccacugcg gggagaugcu guggggccuc gugcgccagg ggcugaagug cgagggcugc      540

ggccugaacu accacaagcg gugcgccuuc aagaucccga acaacugcag cgggguccgc      600

cggcgccggc ucuccaacgu gagccugacg ggcgugucca ccauccgcac cagcuccgcc      660

gagcugagca ccagcgcgcc cgacgagccc cuccugcaga agucccccag cgaguccuuc      720

aucgggcggg agaagcgcag caacucccag agcuacaucg gccggccgau ccaccuggac      780

aagauccuca uguccaaggu caaggugccc cacacguucg ugauccacag cuacacccgc      840

cccaccgucu gccaguacug caagaagcug cugaagggcc ucuuccggca ggggcugcag      900

ugcaaggacu gccgcuucaa cugccacaag cggugcgccc ccaaggugcc gaacaacugc      960

cugggcgagg ugaccaucaa cggggaccuc cugucccccg gcgccgagag cgacgucgug     1020

auggaggagg gguccgacga caacgacagc gagcgcaacu ccggccugau ggacgacaug     1080

gaggaggcca uggugcagga cgccgagaug gcgauggccg agugccagaa cgacagcggc     1140

gagaugcagg accccgaccc cgaccacgag gacgccaacc ggacgaucuc cccgagcacc     1200

uccaacaaca ucccccucau gcgcgucgug cagagcguca agcacaccaa gcgcaagucc     1260

agcaccguga ugaaggaggg guggauggug cacuacacga gcaaggacac ccugcggaag     1320

cgccacuacu ggcggcugga cuccaagugc aucacccucu uccagaacga caccggcagc     1380

cgcuacuaca aggagauccc ccuguccgag auccugagcc ucgagccggu caagacgucc     1440

gcccugaucc ccaacggggc gaacccccac ugcuucgaga ucaccaccgc caacguggug     1500

uacuacgucg gcgagaacgu ggugaacccc agcuccccga gccccaacaa cuccguccug     1560

accagcgggg ugggcgccga cguggcccgg augugggaga ucgccaucca gcacgcgcuc     1620

augcccguca uccccaaggg cuccagcgug gggacgggca ccaaccugca ccgcgacauc     1680

uccgugagca ucuccgucag caacugccag auccaggaga acguggacau cuccaccgug     1740

uaccagaucu ucccggacga gguccugggg agcggccagu ucgggaucgu guacggcggc     1800

aagcaccgga agaccgggcg cgacguggcc aucaagauca ucgacaagcu ccgguucccc     1860

acgaagcagg agagccagcu gcgcaacgag gucgccaucc ugcagaaccu gcaccacccc     1920

ggcgugguga accucgagug cauguucgag acccccgagc gggucuucgu ggugauggag     1980

aagcugcacg gggacaugcu ggagaugauc cucuccagcg agaagggccg ccugccggag     2040

cacaucacca aguuccugau cacccagauc cucgucgccc ugcggcaccu ccacuucaag     2100

aacaucgugc acugcgaccu gaagcccgag aacgugcugc uggccuccgc ggaccccuuc     2160

ccccagguca agcucugcga cuucggcuuc gcccgcauca ucggggagaa guccuuccgg     2220

cgcuccgugg ugggcacgcc ggccuaccug gcccccgagg uccugcggaa caagggguac     2280

aaccgcagcc ucgacaugug guccgugggc gugaucaucu acgucagccu guccgggacc     2340

uuccccuuca acgaggacga ggacauccac gaccagaucc agaacgccgc guucauguac     2400

ccgcccaacc ccuggaagga gaucagccac gaggccaucg accugaucaa caaccuccuc     2460

caggugaaga ugcggaagcg cuacuccgug gacaagaccc ugagccaccc cuggcugcag     2520

gacuaccaga ccuggcugga ccugcgcgag cucgagugca agaucggcga gcgguacauc     2580

acgcacgagu ccgacgaccu gcgcugggag aaguacgccg gcgagcaggg gcugcaguac     2640

cccacccacc ucaucaaccc gagcgccucc cacagcgaca cccccgagac cgaggagacg     2700

gagaugaagg cgcugggcga gcgggucucc auccuguga                            2739


<210>  8860
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCD1__Homo_sapiens__BAG36853

<400>  8860
auguccgccc cccccguccu ccgccccccc uccccccucc uccccgucgc cgccgccgcc       60

gccgccgccg ccgccgcccu cguccccggc uccggccccg gccccgcccc cuuccucgcc      120

cccgucgccg cccccgucgg cggcaucucc uuccaccucc agaucggccu cucccgcgag      180

cccguccucc uccuccagga cuccuccggc gacuacuccc ucgcccacgu ccgcgagaug      240

gccugcucca ucgucgacca gaaguucccc gagugcggcu ucuacggcau guacgacaag      300

auccuccucu uccgccacga ccccaccucc gagaacaucc uccagcucgu caaggccgcc      360

uccgacaucc aggagggcga ccucaucgag gucguccucu ccgccuccgc caccuucgag      420

gacuuccaga uccgccccca cgcccucuuc guccacuccu accgcgcccc cgccuucugc      480

gaccacugcg gcgagaugcu cuggggccuc guccgccagg gccucaagug cgagggcugc      540

ggccucaacu accacaagcg cugcgccuuc aagaucccca acaacugcuc cggcguccgc      600

cgccgccgcc ucuccaacgu cucccucacc ggcgucucca ccauccgcac cuccuccgcc      660

gagcucucca ccuccgcccc cgacgagccc cuccuccaga agucccccuc cgaguccuuc      720

aucggccgcg agaagcgcuc caacucccag uccuacaucg gccgccccau ccaccucgac      780

aagauccuca uguccaaggu caaggucccc cacaccuucg ucauccacuc cuacacccgc      840

cccaccgucu gccaguacug caagaagcuc cucaagggcc ucuuccgcca gggccuccag      900

ugcaaggacu gccgcuucaa cugccacaag cgcugcgccc ccaagguccc caacaacugc      960

cucggcgagg ucaccaucaa cggcgaccuc cucucccccg gcgccgaguc cgacgucguc     1020

auggaggagg gcuccgacga caacgacucc gagcgcaacu ccggccucau ggacgacaug     1080

gaggaggcca ugguccagga cgccgagaug gccauggccg agugccagaa cgacuccggc     1140

gagaugcagg accccgaccc cgaccacgag gacgccaacc gcaccaucuc ccccuccacc     1200

uccaacaaca ucccccucau gcgcgucguc caguccguca agcacaccaa gcgcaagucc     1260

uccaccguca ugaaggaggg cuggaugguc cacuacaccu ccaaggacac ccuccgcaag     1320

cgccacuacu ggcgccucga cuccaagugc aucacccucu uccagaacga caccggcucc     1380

cgcuacuaca aggagauccc ccucuccgag auccucuccc ucgagcccgu caagaccucc     1440

gcccucaucc ccaacggcgc caacccccac ugcuucgaga ucaccaccgc caacgucguc     1500

uacuacgucg gcgagaacgu cgucaacccc uccucccccu cccccaacaa cuccguccuc     1560

accuccggcg ucggcgccga cgucgcccgc augugggaga ucgccaucca gcacgcccuc     1620

augcccguca uccccaaggg cuccuccguc ggcaccggca ccaaccucca ccgcgacauc     1680

uccgucucca ucuccgucuc caacugccag auccaggaga acgucgacau cuccaccguc     1740

uaccagaucu uccccgacga gguccucggc uccggccagu ucggcaucgu cuacggcggc     1800

aagcaccgca agaccggccg cgacgucgcc aucaagauca ucgacaagcu ccgcuucccc     1860

accaagcagg agucccagcu ccgcaacgag gucgccaucc uccagaaccu ccaccacccc     1920

ggcgucguca accucgagug cauguucgag acccccgagc gcgucuucgu cgucauggag     1980

aagcuccacg gcgacaugcu cgagaugauc cucuccuccg agaagggccg ccuccccgag     2040

cacaucacca aguuccucau cacccagauc cucgucgccc uccgccaccu ccacuucaag     2100

aacaucgucc acugcgaccu caagcccgag aacguccucc ucgccuccgc cgaccccuuc     2160

ccccagguca agcucugcga cuucggcuuc gcccgcauca ucggcgagaa guccuuccgc     2220

cgcuccgucg ucggcacccc cgccuaccuc gcccccgagg uccuccgcaa caagggcuac     2280

aaccgcuccc ucgacaugug guccgucggc gucaucaucu acgucucccu cuccggcacc     2340

uuccccuuca acgaggacga ggacauccac gaccagaucc agaacgccgc cuucauguac     2400

ccccccaacc ccuggaagga gaucucccac gaggccaucg accucaucaa caaccuccuc     2460

caggucaaga ugcgcaagcg cuacuccguc gacaagaccc ucucccaccc cuggcuccag     2520

gacuaccaga ccuggcucga ccuccgcgag cucgagugca agaucggcga gcgcuacauc     2580

acccacgagu ccgacgaccu ccgcugggag aaguacgccg gcgagcaggg ccuccaguac     2640

cccacccacc ucaucaaccc cuccgccucc cacuccgaca cccccgagac cgaggagacc     2700

gagaugaagg cccucggcga gcgcgucucc auccucuga                            2739


<210>  8861
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCD1__Homo_sapiens__BAG36853

<400>  8861
augagcgcuc ccccugugcu gagaccaccg aguccccucc uuccugucgc cgcagccgcg       60

gcugccgcag ccgcugcacu gguuccaggc ucugggcccg gaccugcccc auucuuggcu      120

cccguggccg cgccuguagg uggcaucuca uuucacuuac agauugggcu gaguagggag      180

ccagugcuac uccugcaaga cagcuccgga gauuacucuc uugcacaugu ccgggaaaug      240

gccugcucga uaguggacca gaaguucccg gaguguggcu uuuaugguau guacgauaaa      300

auccuguugu uccgccacga ccccaccuca gaaaacauuc uccagcuggu uaaggcugcc      360

agcgauaucc aggaggggga ccugauugaa gugguccuca gugcauccgc uacauuugag      420

gauuuccaaa uccgaccuca ugccuuauuu gugcacucuu aucgugcgcc agccuucugc      480

gaccauugug gagagaugcu guggggccuu guaagacagg gcuugaaaug cgaagggugu      540

ggacugaauu accacaagag gugcgcauuu aaaauaccca acaauuguag cgguguucgg      600

cgcagaaggc uauccaacgu gucacucacu ggcgucagua cgauccggac cagcucugcu      660

gagcugucca caucagcccc ugaugaacca cuucugcaaa agagccccag ugagucuuuc      720

auugggcgcg agaagcgauc caauagccag ucguauaucg gaagaccgau ucacuuggac      780

aaaauccuca ugucuaaggu gaaagugccu cauacuuuug ucauacacuc cuacaccagg      840

cccacaguuu gccaguauug uaagaaacug uuaaagggcc uguuccggca gggucuccag      900

ugcaaggauu gucguuuuaa cugccauaaa cgcugcgcuc caaaggugcc uaauaacugu      960

cuuggggaag uaaccauuaa uggagaccug uugucacccg gcgccgagag ugaugugguc     1020

auggaagagg gcagcgacga caacgauucc gaaagaaauu cugggcuaau ggacgauaug     1080

gaggaggcaa uggugcagga cgccgaaaug gcuauggcgg agugccaaaa cgauagcgga     1140

gaaaugcagg acccagaucc cgaccacgag gaugcaaaua ggacuaucuc accuaguaca     1200

uccaacaaua uuccacugau gcggguugug cagagcguca aacacaccaa gcgaaaaucu     1260

ucaacgguga ugaaggaagg uuggauggua cauuacacuu ccaaagacac ccuccgcaag     1320

agacacuacu ggaggcugga uagcaagugu aucacacuuu uccaaaacga cacuggcucc     1380

cgguauuaca aagagauccc gcugucugag auuuugucgc ucgaacccgu uaagaccagc     1440

gcccugauac cuaacggggc uaauccacau ugcuucgaga ucacaaccgc caacgugguc     1500

uauuacgugg gagaaaaugu cgugaacccc uccucaccua guccaaauaa cucuguuuua     1560

acgagcggcg ugggugcaga cguagcccgc augugggaga uugcuaucca gcacgcccug     1620

augcccguca uaccgaaagg guccucagug ggcacuggaa caaaucuaca uagagauauu     1680

agcguuucua ucuccgugag uaacugucag auccaggaaa augucgacau uagcaccgug     1740

uaucaaaucu uuccugauga gguacucggc ucugggcagu ucggaauugu guacgguggc     1800

aagcacagga aaacugggcg ugacguugca auaaagauca uugauaagcu gcgguuucca     1860

acaaaacagg agucccagcu ucgaaacgaa gucgcgaucu ugcaaaaucu gcaccauccc     1920

ggagugguga accucgagug cauguucgaa accccugaga gagucuuugu ugugauggag     1980

aagcugcacg gcgacaugcu ugaaaugauc cugucaagug agaaagguag guugcccgaa     2040

cauauuacga aguuccucau aacccagauc cugguggcuu uacgccaccu ucacuuuaaa     2100

aauauuguac auugugaucu aaagccagag aacguccucc uggccagcgc agacccuuuc     2160

ccccagguga agcugugcga uuuuggguuc gcccggauca uuggcgaaaa aucguuuaga     2220

agguccguug ugggaacacc agcuuauuug gccccggagg uccugcgcaa uaagggcuac     2280

aaccgaucuc ucgacaugug gagcgugggg guuaucauau acgugucacu gaguggaacu     2340

uucccuuuua acgaggauga agacauccac gaucagauuc aaaaugcagc uuucauguau     2400

cccccaaacc ccuggaaaga gaucucccau gaagccauug acuuaaucaa uaaccugcuu     2460

cagguaaaga ugcggaaacg uuacucuguc gacaagaccu ugagccaccc uuggcuccag     2520

gauuaucaga cauggcugga ccuaagagag cuggaaugua agauagguga gagguacauu     2580

acucaugagu ccgaugaccu ccgcugggaa aaauaugcgg gcgagcaagg gcugcaguac     2640

ccaacccacc uuaucaaucc cucagccagc cacagugaua caccugaaac cgaggaaacu     2700

gagaugaagg cuuugggaga gcgggugucu auucuguga                            2739


<210>  8862
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCD1__Homo_sapiens__BAG36853

<400>  8862
augagcgccc cccccgugcu gagacccccc agcccccugc ugcccguggc cgccgccgcc       60

gccgccgccg ccgccgcccu ggugcccggc agcggccccg gccccgcccc cuuccuggcc      120

cccguggccg cccccguggg cggcaucagc uuccaccugc agaucggccu gagcagagag      180

cccgugcugc ugcugcagga cagcagcggc gacuacagcc uggcccacgu gagagagaug      240

gccugcagca ucguggacca gaaguucccc gagugcggcu ucuacggcau guacgacaag      300

auccugcugu ucagacacga ccccaccagc gagaacaucc ugcagcuggu gaaggccgcc      360

agcgacaucc aggagggcga ccugaucgag guggugcuga gcgccagcgc caccuucgag      420

gacuuccaga ucagacccca cgcccuguuc gugcacagcu acagagcccc cgccuucugc      480

gaccacugcg gcgagaugcu guggggccug gugagacagg gccugaagug cgagggcugc      540

ggccugaacu accacaagag augcgccuuc aagaucccca acaacugcag cggcgugaga      600

agaagaagac ugagcaacgu gagccugacc ggcgugagca ccaucagaac cagcagcgcc      660

gagcugagca ccagcgcccc cgacgagccc cugcugcaga agagccccag cgagagcuuc      720

aucggcagag agaagagaag caacagccag agcuacaucg gcagacccau ccaccuggac      780

aagauccuga ugagcaaggu gaaggugccc cacaccuucg ugauccacag cuacaccaga      840

cccaccgugu gccaguacug caagaagcug cugaagggcc uguucagaca gggccugcag      900

ugcaaggacu gcagauucaa cugccacaag agaugcgccc ccaaggugcc caacaacugc      960

cugggcgagg ugaccaucaa cggcgaccug cugagccccg gcgccgagag cgacguggug     1020

auggaggagg gcagcgacga caacgacagc gagagaaaca gcggccugau ggacgacaug     1080

gaggaggcca uggugcagga cgccgagaug gccauggccg agugccagaa cgacagcggc     1140

gagaugcagg accccgaccc cgaccacgag gacgccaaca gaaccaucag ccccagcacc     1200

agcaacaaca ucccccugau gagaguggug cagagcguga agcacaccaa gagaaagagc     1260

agcaccguga ugaaggaggg cuggauggug cacuacacca gcaaggacac ccugagaaag     1320

agacacuacu ggagacugga cagcaagugc aucacccugu uccagaacga caccggcagc     1380

agauacuaca aggagauccc ccugagcgag auccugagcc uggagcccgu gaagaccagc     1440

gcccugaucc ccaacggcgc caacccccac ugcuucgaga ucaccaccgc caacguggug     1500

uacuacgugg gcgagaacgu ggugaacccc agcagcccca gccccaacaa cagcgugcug     1560

accagcggcg ugggcgccga cguggccaga augugggaga ucgccaucca gcacgcccug     1620

augcccguga uccccaaggg cagcagcgug ggcaccggca ccaaccugca cagagacauc     1680

agcgugagca ucagcgugag caacugccag auccaggaga acguggacau cagcaccgug     1740

uaccagaucu uccccgacga ggugcugggc agcggccagu ucggcaucgu guacggcggc     1800

aagcacagaa agaccggcag agacguggcc aucaagauca ucgacaagcu gagauucccc     1860

accaagcagg agagccagcu gagaaacgag guggccaucc ugcagaaccu gcaccacccc     1920

ggcgugguga accuggagug cauguucgag acccccgaga gaguguucgu ggugauggag     1980

aagcugcacg gcgacaugcu ggagaugauc cugagcagcg agaagggcag acugcccgag     2040

cacaucacca aguuccugau cacccagauc cugguggccc ugagacaccu gcacuucaag     2100

aacaucgugc acugcgaccu gaagcccgag aacgugcugc uggccagcgc cgaccccuuc     2160

ccccagguga agcugugcga cuucggcuuc gccagaauca ucggcgagaa gagcuucaga     2220

agaagcgugg ugggcacccc cgccuaccug gcccccgagg ugcugagaaa caagggcuac     2280

aacagaagcc uggacaugug gagcgugggc gugaucaucu acgugagccu gagcggcacc     2340

uuccccuuca acgaggacga ggacauccac gaccagaucc agaacgccgc cuucauguac     2400

ccccccaacc ccuggaagga gaucagccac gaggccaucg accugaucaa caaccugcug     2460

caggugaaga ugagaaagag auacagcgug gacaagaccc ugagccaccc cuggcugcag     2520

gacuaccaga ccuggcugga ccugagagag cuggagugca agaucggcga gagauacauc     2580

acccacgaga gcgacgaccu gagaugggag aaguacgccg gcgagcaggg ccugcaguac     2640

cccacccacc ugaucaaccc cagcgccagc cacagcgaca cccccgagac cgaggagacc     2700

gagaugaagg cccugggcga gagagugagc auccuguga                            2739


<210>  8863
<211>  2739
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCD1__Homo_sapiens__BAG36853

<400>  8863
augagcgcuc ccccugugcu gagaccgccc uccccucucc ugcccgucgc cgccgcggcu       60

gccgccgcug ccgcugcccu uguuccuggc ucugggcccg gaccugcgcc guuccuggcc      120

cccguggcug ccccuguggg cgggaucagc uuucaccucc agauuggacu gucccgggag      180

cccguccuuc ugcuccaaga cucuagcggc gauuacuccc uggcucaugu gcgcgaaaug      240

gccugcucua ucguugacca gaaguucccu gagugugggu uuuauggaau guacgauaaa      300

auucuccugu ucagacacga ccccaccagc gaaaacaucc ugcagcuugu gaaggcggcc      360

uccgauauuc aggagggcga ccugaucgaa gucgugcuca gcgcuucugc cacauuugag      420

gauuuccaaa uccggccgca ugcucuguuu guucacuccu aucgcgcccc ugccuucugc      480

gaccauugug gcgagaugcu uugggggcug gugagacagg gacucaaaug cgaaggcugu      540

gggcugaauu accacaagcg gugcgcuuuu aaaauuccca acaauuguag cggaguccgc      600

agacggcgcc ugucuaacgu gucccucacg ggcgugagca ccaucagaac aucuuccgcg      660

gagcugagca ccuccgcccc ugaugaaccc cuucugcaga agucucccag cgaguccuuc      720

auugggcggg agaagcgcag caauucucag uccuauaucg gaagaccuau ucaccucgac      780

aaaauccuga ugagcaaggu caaaguuccg cauacauuug ugauucacuc uuacacccgg      840

cccacagugu gccaauauug uaagaaacuu cugaagggcc ucuuccgcca gggccugcag      900

ugcaaggauu guagauuuaa cugccauaaa cggugcgcuc cuaagguccc caauaacugu      960

cugggggaag ugaccaucaa uggagaccuc cugagcccug gcgccgaguc cgauguugug     1020

auggaagagg ggucugacga caacgauagc gaaagaaauu ccggacuuau ggacgauaug     1080

gaggaggcca ugguccagga cgcugaaaug gccauggcgg agugccaaaa cgauagcggc     1140

gaaaugcagg accccgaucc ggaccacgag gaugcuaauc gcacgaucuc uccuuccacc     1200

agcaacaaua uuccccugau gcgggugguu cagucuguga aacacacaaa gagaaaaucc     1260

agcaccguca ugaaggaagg guggauggug cauuacacau ccaaagacac ccuccgcaag     1320

cggcacuacu ggagacugga uucuaagugu aucacgcuuu uccaaaacga cacaggaagc     1380

cgcuauuaca aagagauucc ucuguccgag auccucucuc uggaacccgu caagaccagc     1440

gcccugauuc cuaacggcgc caauccccau ugcuucgaga ucacaaccgc uaacgugguu     1500

uauuacgugg gcgaaaaugu cgugaacccg uccagcccuu cucccaauaa cuccguucuc     1560

accagcgggg ugggagccga cgucgcucgg augugggaga ucgccauuca gcacgcgcug     1620

augcccguga ucccuaaagg cagcuccgug gggacaggaa cgaaucuuca uagagauauu     1680

agcguuucua ucagcgucuc caacugucag auucaggaaa auguggacau cagcaccgug     1740

uaucaaaucu uuccggauga gguccugggc ucugggcagu ucggcauugu guacggaggc     1800

aagcaccgca aaacagggcg ggacguugcc aucaagauua ucgauaagcu cagauuuccc     1860

accaaacagg agucccagcu gcgcaacgaa guggcuauuc ugcaaaaucu ucaccauccu     1920

ggagucguga accucgagug cauguucgaa acacccgagc ggguuuuugu ggucauggag     1980

aagcugcacg gcgacaugcu ggaaaugauc cucagcuccg agaaagggag acugccugaa     2040

cauauuacca aguuccuuau cacgcagauc cugguggccc uccggcaucu gcacuuuaaa     2100

aauauuguuc acugugaucu gaagcccgag aacgugcuuc ucgcuucugc cgacccuuuc     2160

ccccagguca agcugugcga uuuuggauuc gcgcgcauca uuggcgaaaa aucuuuuaga     2220

cgguccgugg uggggacacc ggccuaucug gcuccugagg uccucagaaa uaagggcuac     2280

aaccgcucuc uggacaugug gagcguugga gugaucauuu acgugucccu uucuggcacc     2340

uuccccuuua acgaggauga agacauccac gaucagaucc aaaaugccgc uuucauguau     2400

ccucccaacc cguggaaaga gauuagccau gaagccaucg accugauuaa uaaccuccug     2460

caggucaaga ugcggaaaag auacuccgug gacaagaccc ugagccaccc uuggcuucag     2520

gauuaucaga cauggcucga ccugcgcgag cuggaaugua agaucgggga gagauacauu     2580

acccaugagu cugaugaccu ccggugggaa aaauaugccg gagagcaagg ccugcaguac     2640

cccacacacc uuaucaaucc uuccgcuagc cacucugaua cgcccgaaac cgaggaaaca     2700

gagaugaagg cgcuggggga gcgcguuucc auccucuga                            2739


<210>  8864
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCD3__Homo_sapiens__O94806

<400>  8864

Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210>  8865
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCD3__Homo_sapiens__AAY14817

<400>  8865
augucugcaa auaauucccc uccaucagcc cagaagucug uauuacccac agcuauuccu       60

gcugugcuuc cagcugcuuc uccguguuca aguccuaaga cgggacucuc ugcccgacuc      120

ucuaauggaa gcuucagugc accaucacuc accaacucca gaggcucagu gcauacaguu      180

ucauuucuac ugcaaauugg ccucacacgg gagaguguua ccauugaagc ccaggaacug      240

ucuuuaucug cugucaagga ucuugugugc uccauaguuu aucaaaaguu uccagagugu      300

ggauucuuug gcauguauga caaaauucuu cucuuucgcc augacaugaa cucagaaaac      360

auuuugcagc ugauuaccuc agcagaugaa auacaugaag gagaccuagu ggaagugguu      420

cuuucagcuu uagccacagu agaagacuuc cagauucguc cacauacucu cuauguacau      480

ucuuacaaag cuccuacuuu cugugauuac uguggugaga ugcucugggg auugguacgu      540

caaggacuga aaugugaagg cuguggauua aauuaccaua aacgaugugc cuucaagauu      600

ccaaauaacu guaguggagu aagaaagaga cgucugucaa auguaucuuu accaggaccc      660

ggccucucag uuccaagacc ccuacagccu gaauauguag cccuucccag ugaagaguca      720

cauguccacc aggaaccaag uaagagaauu ccuucuugga guggucgccc aaucuggaug      780

gaaaagaugg uaaugugcag agugaaaguu ccacacacau uugcuguuca cucuuacacc      840

cgucccacga uaugucagua cugcaagcgg uuacugaaag gccucuuucg ccaaggaaug      900

caguguaaag auugcaaauu caacugccau aaacgcugug caucaaaagu accaagagac      960

ugccuuggag agguuacuuu caauggagaa ccuuccaguc ugggaacaga uacagauaua     1020

ccaauggaua uugacaauaa ugacauaaau agugauagua gucgggguuu ggaugacaca     1080

gaagagccau cacccccaga agauaagaug uucuucuugg auccaucuga ucucgaugug     1140

gaaagagaug aagaagccgu uaaaacaauc aguccaucaa caagcaauaa uauuccgcua     1200

augaggguug uacaauccau caagcacaca aagaggaaga gcagcacaau ggugaaggaa     1260

ggguggaugg uccauuacac cagcagggau aaccugagaa agaggcauua uuggagacuu     1320

gacagcaaau gucuaacauu auuucagaau gaaucuggau caaaguauua uaaggaaauu     1380

ccacuuucag aaauucuccg cauaucuuca ccacgagauu ucacaaacau uucacaaggc     1440

agcaauccac acuguuuuga aaucauuacu gauacuaugg uauacuucgu uggugagaac     1500

aauggggaca gcucucauaa uccuguucuu gcugccacug gaguuggacu ugauguagca     1560

cagagcuggg aaaaagcaau ucgccaagcc cucaugccug uuacuccuca agcaaguguu     1620

ugcacuucuc cagggcaagg gaaagaucac aaagauuugu cuacaaguau cucuguaucu     1680

aauugucaga uucaggagaa uguggauauc aguacuguuu accagaucuu ugcagaugag     1740

gugcuugguu caggccaguu uggcaucguu uauggaggaa aacauagaaa gacugggagg     1800

gauguggcua uuaaaguaau ugauaagaug agauucccca caaaacaaga aagucaacuc     1860

cguaaugaag uggcuauuuu acagaauuug caccauccug ggauuguaaa ccuggaaugu     1920

auguuugaaa ccccagaacg agucuuugua guaauggaaa agcugcaugg agauauguug     1980

gaaaugauuc uauccaguga gaaaagucgg cuuccagaac gaauuacuaa auucaugguc     2040

acacagauac uuguugcuuu gaggaaucug cauuuuaaga auauugugca cugugauuua     2100

aagccagaaa augugcugcu ugcaucagca gagccauuuc cucaggugaa gcugugugac     2160

uuuggauuug cacgcaucau uggugaaaag ucauucagga gaucuguggu aggaacucca     2220

gcauacuuag ccccugaagu ucuccggagc aaagguuaca accguucccu agauaugugg     2280

ucagugggag uuaucaucua ugugagccuc aguggcacau uuccuuuuaa ugaggaugaa     2340

gauauaaaug accaaaucca aaaugcugca uuuauguacc caccaaaucc auggagagaa     2400

auuucuggug aagcaauuga ucugauaaac aaucugcuuc aagugaagau gagaaaacgu     2460

uacaguguug acaaaucucu uagucauccc uggcuacagg acuaucagac uuggcuugac     2520

cuuagagaau uugaaacucg cauuggagaa cguuacauua cacaugaaag ugaugaugcu     2580

cgcugggaaa uacaugcaua cacacauaac cuuguauacc caaagcacuu cauuauggcu     2640

ccuaauccag augauaugga agaagauccu uaa                                  2673


<210>  8866
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCD3__Homo_sapiens__AAY14817

<400>  8866
augagcgcca acaacucccc gcccagcgcc cagaaguccg ugcugcccac cgcgaucccc       60

gccguccucc ccgccgccag cccgugcucc agccccaaga ccggccuguc cgcccgccug      120

agcaacgggu ccuucagcgc gcccucccuc acgaacagcc ggggcuccgu gcacaccgug      180

agcuuccugc ugcagaucgg gcucacccgc gaguccguca ccaucgaggc ccaggagcug      240

agccuguccg ccgugaagga ccucgugugc agcaucgucu accagaaguu ccccgagugc      300

ggcuucuucg ggauguacga caagauccug cuguuccggc acgacaugaa cuccgagaac      360

auccuccagc ugaucacgag cgccgacgag auccacgagg gcgaccuggu ggaggugguc      420

cucagcgcgc uggccaccgu ggaggacuuc cagauccgcc cgcacacccu guacgugcac      480

uccuacaagg cccccaccuu cugcgacuac ugcggcgaga ugcucugggg gcugguccgg      540

cagggccuga agugcgaggg gugcggccuc aacuaccaca agcgcugcgc cuucaagauc      600

cccaacaacu gcagcggggu gcggaagcgc cggcugucca acgugagccu gcccggcccg      660

ggccucuccg ucccccgccc ccugcagccc gaguacgugg cccugccgag cgaggagucc      720

cacgugcacc aggagcccag caagcggauc cccuccugga gcgggcgccc caucuggaug      780

gagaagaugg ucaugugccg ggugaaggug ccgcacacgu ucgcggucca cuccuacacc      840

cgccccacca ucugccagua cugcaagcgg cuccugaagg gccuguuccg ccaggggaug      900

cagugcaagg acugcaaguu caacugccac aagcggugcg ccagcaaggu gccccgcgac      960

ugccucggcg aggugaccuu caacggcgag cccuccagcc uggggacgga caccgacauc     1020

ccgauggaca ucgacaacaa cgacaucaac uccgacagcu cccggggccu ggacgacacc     1080

gaggagccca gcccgcccga ggacaagaug uucuuccucg accccuccga ccuggacguc     1140

gagcgcgacg aggaggccgu gaagaccauc agccccagca cguccaacaa caucccccug     1200

augcgggucg ugcagagcau caagcacacc aagcgcaagu ccagcaccau ggugaaggag     1260

ggguggaugg uccacuacac cucccgcgac aaccuccgga agcgccacua cuggcggcug     1320

gacagcaagu gccugacccu cuuccagaac gaguccggca gcaaguacua caaggagauc     1380

ccgcuguccg agauccugcg caucagcagc ccccgggacu ucaccaacau cucccagggg     1440

uccaaccccc acugcuucga gaucaucacc gacaccaugg uguacuucgu gggcgagaac     1500

aacggcgaca gcucccacaa ccccguccuc gccgccacgg gggugggccu ggacguggcg     1560

cagagcuggg agaaggccau ccgccaggcc cugaugccgg ucacgcccca ggccuccgug     1620

ugcaccagcc ccgggcaggg caaggaccac aaggaccuca gcaccuccau cagcgugucc     1680

aacugccaga uccaggagaa cgucgacauc agcacggugu accagaucuu cgccgacgag     1740

gugcuggggu ccggccaguu cggcaucguc uacgggggca agcaccggaa gaccgggcgc     1800

gacguggcga ucaaggugau cgacaagaug cgguucccca ccaagcagga gagccagcug     1860

cgcaacgagg ucgccauccu ccagaaccug caccacccgg gcaucgugaa ccuggagugc     1920

auguucgaga cccccgagcg gguguucguc gugauggaga agcugcacgg ggacaugcuc     1980

gagaugaucc uguccagcga gaagucccgc cugcccgagc ggaucacgaa guucauggug     2040

acccagaucc ucgucgcccu gcgcaaccug cacuucaaga acaucgugca cugcgaccuc     2100

aagcccgaga acgugcugcu ggccagcgcc gagccguucc cccaggucaa gcucugcgac     2160

uucggcuucg cgcggaucau cggcgagaag uccuuccgcc ggagcguggu ggggaccccc     2220

gccuaccugg cccccgaggu ccugcgcucc aagggcuaca accggagccu cgacaugugg     2280

uccguggggg ugaucaucua cgucagccug uccggcaccu ucccguucaa cgaggacgag     2340

gacaucaacg accagaucca gaacgccgcg uucauguacc cgcccaaccc cuggcgcgag     2400

aucagcggcg aggccaucga ccugaucaac aaccuccucc aggugaagau gcgcaagcgg     2460

uacuccgugg acaagagccu gagccacccc uggcugcagg acuaccagac guggcuggac     2520

cugcgcgagu ucgagacccg gaucggggag cgcuacauca cccacgaguc cgacgacgcc     2580

cggugggaga uccacgccua cacccacaac cucgucuacc ccaagcacuu caucauggcc     2640

cccaaccccg acgacaugga ggaggacccg uga                                  2673


<210>  8867
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCD3__Homo_sapiens__AAY14817

<400>  8867
auguccgcca acaacucccc ccccuccgcc cagaaguccg uccuccccac cgccaucccc       60

gccguccucc ccgccgccuc ccccugcucc ucccccaaga ccggccucuc cgcccgccuc      120

uccaacggcu ccuucuccgc ccccucccuc accaacuccc gcggcuccgu ccacaccguc      180

uccuuccucc uccagaucgg ccucacccgc gaguccguca ccaucgaggc ccaggagcuc      240

ucccucuccg ccgucaagga ccucgucugc uccaucgucu accagaaguu ccccgagugc      300

ggcuucuucg gcauguacga caagauccuc cucuuccgcc acgacaugaa cuccgagaac      360

auccuccagc ucaucaccuc cgccgacgag auccacgagg gcgaccucgu cgaggucguc      420

cucuccgccc ucgccaccgu cgaggacuuc cagauccgcc cccacacccu cuacguccac      480

uccuacaagg cccccaccuu cugcgacuac ugcggcgaga ugcucugggg ccucguccgc      540

cagggccuca agugcgaggg cugcggccuc aacuaccaca agcgcugcgc cuucaagauc      600

cccaacaacu gcuccggcgu ccgcaagcgc cgccucucca acgucucccu ccccggcccc      660

ggccucuccg ucccccgccc ccuccagccc gaguacgucg cccuccccuc cgaggagucc      720

cacguccacc aggagcccuc caagcgcauc cccuccuggu ccggccgccc caucuggaug      780

gagaagaugg ucaugugccg cgucaagguc ccccacaccu ucgccgucca cuccuacacc      840

cgccccacca ucugccagua cugcaagcgc cuccucaagg gccucuuccg ccagggcaug      900

cagugcaagg acugcaaguu caacugccac aagcgcugcg ccuccaaggu cccccgcgac      960

ugccucggcg aggucaccuu caacggcgag cccuccuccc ucggcaccga caccgacauc     1020

cccauggaca ucgacaacaa cgacaucaac uccgacuccu cccgcggccu cgacgacacc     1080

gaggagcccu ccccccccga ggacaagaug uucuuccucg accccuccga ccucgacguc     1140

gagcgcgacg aggaggccgu caagaccauc ucccccucca ccuccaacaa caucccccuc     1200

augcgcgucg uccaguccau caagcacacc aagcgcaagu ccuccaccau ggucaaggag     1260

ggcuggaugg uccacuacac cucccgcgac aaccuccgca agcgccacua cuggcgccuc     1320

gacuccaagu gccucacccu cuuccagaac gaguccggcu ccaaguacua caaggagauc     1380

ccccucuccg agauccuccg caucuccucc ccccgcgacu ucaccaacau cucccagggc     1440

uccaaccccc acugcuucga gaucaucacc gacaccaugg ucuacuucgu cggcgagaac     1500

aacggcgacu ccucccacaa ccccguccuc gccgccaccg gcgucggccu cgacgucgcc     1560

caguccuggg agaaggccau ccgccaggcc cucaugcccg ucacccccca ggccuccguc     1620

ugcaccuccc ccggccaggg caaggaccac aaggaccucu ccaccuccau cuccgucucc     1680

aacugccaga uccaggagaa cgucgacauc uccaccgucu accagaucuu cgccgacgag     1740

guccucggcu ccggccaguu cggcaucguc uacggcggca agcaccgcaa gaccggccgc     1800

gacgucgcca ucaaggucau cgacaagaug cgcuucccca ccaagcagga gucccagcuc     1860

cgcaacgagg ucgccauccu ccagaaccuc caccaccccg gcaucgucaa ccucgagugc     1920

auguucgaga cccccgagcg cgucuucguc gucauggaga agcuccacgg cgacaugcuc     1980

gagaugaucc ucuccuccga gaagucccgc cuccccgagc gcaucaccaa guucaugguc     2040

acccagaucc ucgucgcccu ccgcaaccuc cacuucaaga acaucgucca cugcgaccuc     2100

aagcccgaga acguccuccu cgccuccgcc gagcccuucc cccaggucaa gcucugcgac     2160

uucggcuucg cccgcaucau cggcgagaag uccuuccgcc gcuccgucgu cggcaccccc     2220

gccuaccucg cccccgaggu ccuccgcucc aagggcuaca accgcucccu cgacaugugg     2280

uccgucggcg ucaucaucua cgucucccuc uccggcaccu uccccuucaa cgaggacgag     2340

gacaucaacg accagaucca gaacgccgcc uucauguacc cccccaaccc cuggcgcgag     2400

aucuccggcg aggccaucga ccucaucaac aaccuccucc aggucaagau gcgcaagcgc     2460

uacuccgucg acaagucccu cucccacccc uggcuccagg acuaccagac cuggcucgac     2520

cuccgcgagu ucgagacccg caucggcgag cgcuacauca cccacgaguc cgacgacgcc     2580

cgcugggaga uccacgccua cacccacaac cucgucuacc ccaagcacuu caucauggcc     2640

cccaaccccg acgacaugga ggaggacccc uga                                  2673


<210>  8868
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCD3__Homo_sapiens__AAY14817

<400>  8868
augagcgcca acaauucccc uccuucugcu cagaagucag ugcugccaac cgcaaucccg       60

gccguccucc ccgcggcuag uccuugcagc uccccaaaaa caggccuuuc ugccagacug      120

ucgaacgggu cauucagcgc acccaguuug acuaauucca ggggaucugu ucacacggug      180

agcuuuuuac ugcaaauugg ucuaacccgg gaguccguaa caauagaagc ccaggagcuc      240

ucacugagug cugugaagga ccuugucugu agcaucgugu accagaaauu cccugaaugc      300

ggcuuuuucg ggauguauga uaagauucug uuguuucgcc augacaugaa cucugagaau      360

auccuccagc ugauuacuuc cgcagaugaa auccacgagg gagaccuggu ugaggugguc      420

cucucagccu uagcuaccgu ggaagauuuc caaauacgac cacauacacu guacguacac      480

agcuauaaag cccccaccuu uugugacuac ugcggcgaga ugcuuugggg uuugguucgu      540

caggggcuga agugugaagg augcggccua aacuaucaua agagaugugc guucaaaauc      600

ccuaauaacu gcaguggcgu gaggaagcgg cgccucucua augucucccu gccagggccg      660

ggacuuagcg ugcccagacc ucugcagcca gaguacgugg cauugcccuc ggaggaaucu      720

cacguccacc aggagccuuc caaaaggauu ccaucaugga guggucggcc caucuggaug      780

gaaaagaugg uuaugugucg cgugaaagua ccgcauacuu uugccgugca cagcuauaca      840

cgaccuacca uuugccaaua cuguaagaga cuccugaagg gcuuauucag gcaggggaug      900

cagugcaaag auugcaaguu uaacugucau aaacggugcg cuuccaaggu cccccgugac      960

ugucugggag aggugacguu caauggcgaa ccaucuagcc ucgguacuga uaccgacauc     1020

ccuauggaua uagacaacaa ugauauuaac ucagacaguu cccgcgggcu ugacgauaca     1080

gaggagccca gcccacccga agacaaaaug uuuuuccugg auccuucuga cuuggauguu     1140

gagagagacg aagaggccgu gaagacuauc ucaccaagua ccagcaauaa cauuccgcua     1200

augagggucg ugcaguccau caaacacaca aagcggaagu cuucgaccau gguaaaagaa     1260

ggauggaugg uucacuacac gagccgagau aaccugcgca agagacauua uuggaggcuc     1320

gacuccaaau gccugacucu uuuccaaaau gagucaggca guaaguacua uaaagagauc     1380

ccccugucug aaauuuugcg gauaagcucc ccucgcgauu uuacaaacau cucacagggc     1440

agcaauccac acuguuucga gauuaucacc gacacuaugg uguacuuugu cggggaaaac     1500

aauggagauu cuucccauaa ccccgugcuc gcagcuacag gugucggccu ggacguggcc     1560

cagaguuggg agaaggcgau aagacaagcc uuaaugccug uuaccccaca ggcaagcgug     1620

ugcacgucuc ccgggcaggg aaaggaccac aaagaucugu ccaccucaau uaguguaagc     1680

aauugucaga uccaagaaaa cgucgacauc ucgacagugu aucagauuuu cgcugaugag     1740

guucuaggcu ccggucaguu ugggaucgug uacggcggaa agcauaggaa aacuggccgu     1800

gacgucgcca uuaaggugau agauaaaaug cgguucccga ccaagcagga gucucaacuc     1860

cgaaaugaag uagcuauccu gcagaaccuu caccacccug ggauugugaa uuuggagugc     1920

auguuugaaa caccagagag aguuuucguc gugauggaga agcugcaugg agacaugcuc     1980

gaaaugaucc ugagcucaga gaaaaguagg cuucccgaac gcaucacuaa guuuauggug     2040

acccagauuc uggucgccuu gcggaaccuc cacuucaaaa auauaguuca uugugaucug     2100

aagccugaga acguguuacu ggcauccgcc gaacccuuuc cacaggugaa acuaugcgac     2160

uucgguuuug cuagaaucau uggcgagaag ucuuucaggc gcagcguagu cgggacaccc     2220

gcguaucucg cacccgaggu gcugcgaucc aagggauaca aucggucacu ugauaugugg     2280

agcguuggcg ugaucauuua cgucaguuug ucugguaccu ucccauuuaa cgaagacgag     2340

gauaucaacg accaaauaca gaaugccgcu uucauguauc cgccuaaccc cuggcgugaa     2400

aucuccgggg aggccauuga ucugaucaau aaccucuuac aggugaaaau gagaaagagg     2460

uacagcguug acaaaucgcu gucacaccca uggcugcagg acuaucaaac uuggcuugau     2520

uugcgcgaau uugagacgcg gauuggcgag agauacauca cacacgaauc ugacgaugca     2580

aggugggaga uacaugccua uacccacaau cucguguacc ccaagcauuu cauuauggcu     2640

ccuaacccag acgauaugga agaggacccc uga                                  2673


<210>  8869
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCD3__Homo_sapiens__AAY14817

<400>  8869
augagcgcca acaacagccc ccccagcgcc cagaagagcg ugcugcccac cgccaucccc       60

gccgugcugc ccgccgccag ccccugcagc agccccaaga ccggccugag cgccagacug      120

agcaacggca gcuucagcgc ccccagccug accaacagca gaggcagcgu gcacaccgug      180

agcuuccugc ugcagaucgg ccugaccaga gagagcguga ccaucgaggc ccaggagcug      240

agccugagcg ccgugaagga ccuggugugc agcaucgugu accagaaguu ccccgagugc      300

ggcuucuucg gcauguacga caagauccug cuguucagac acgacaugaa cagcgagaac      360

auccugcagc ugaucaccag cgccgacgag auccacgagg gcgaccuggu ggagguggug      420

cugagcgccc uggccaccgu ggaggacuuc cagaucagac cccacacccu guacgugcac      480

agcuacaagg cccccaccuu cugcgacuac ugcggcgaga ugcugugggg ccuggugaga      540

cagggccuga agugcgaggg cugcggccug aacuaccaca agagaugcgc cuucaagauc      600

cccaacaacu gcagcggcgu gagaaagaga agacugagca acgugagccu gcccggcccc      660

ggccugagcg ugcccagacc ccugcagccc gaguacgugg cccugcccag cgaggagagc      720

cacgugcacc aggagcccag caagagaauc cccagcugga gcggcagacc caucuggaug      780

gagaagaugg ugaugugcag agugaaggug ccccacaccu ucgccgugca cagcuacacc      840

agacccacca ucugccagua cugcaagaga cugcugaagg gccuguucag acagggcaug      900

cagugcaagg acugcaaguu caacugccac aagagaugcg ccagcaaggu gcccagagac      960

ugccugggcg aggugaccuu caacggcgag cccagcagcc ugggcaccga caccgacauc     1020

cccauggaca ucgacaacaa cgacaucaac agcgacagca gcagaggccu ggacgacacc     1080

gaggagccca gcccccccga ggacaagaug uucuuccugg accccagcga ccuggacgug     1140

gagagagacg aggaggccgu gaagaccauc agccccagca ccagcaacaa caucccccug     1200

augagagugg ugcagagcau caagcacacc aagagaaaga gcagcaccau ggugaaggag     1260

ggcuggaugg ugcacuacac cagcagagac aaccugagaa agagacacua cuggagacug     1320

gacagcaagu gccugacccu guuccagaac gagagcggca gcaaguacua caaggagauc     1380

ccccugagcg agauccugag aaucagcagc cccagagacu ucaccaacau cagccagggc     1440

agcaaccccc acugcuucga gaucaucacc gacaccaugg uguacuucgu gggcgagaac     1500

aacggcgaca gcagccacaa ccccgugcug gccgccaccg gcgugggccu ggacguggcc     1560

cagagcuggg agaaggccau cagacaggcc cugaugcccg ugacccccca ggccagcgug     1620

ugcaccagcc ccggccaggg caaggaccac aaggaccuga gcaccagcau cagcgugagc     1680

aacugccaga uccaggagaa cguggacauc agcaccgugu accagaucuu cgccgacgag     1740

gugcugggca gcggccaguu cggcaucgug uacggcggca agcacagaaa gaccggcaga     1800

gacguggcca ucaaggugau cgacaagaug agauucccca ccaagcagga gagccagcug     1860

agaaacgagg uggccauccu gcagaaccug caccaccccg gcaucgugaa ccuggagugc     1920

auguucgaga cccccgagag aguguucgug gugauggaga agcugcacgg cgacaugcug     1980

gagaugaucc ugagcagcga gaagagcaga cugcccgaga gaaucaccaa guucauggug     2040

acccagaucc ugguggcccu gagaaaccug cacuucaaga acaucgugca cugcgaccug     2100

aagcccgaga acgugcugcu ggccagcgcc gagcccuucc cccaggugaa gcugugcgac     2160

uucggcuucg ccagaaucau cggcgagaag agcuucagaa gaagcguggu gggcaccccc     2220

gccuaccugg cccccgaggu gcugagaagc aagggcuaca acagaagccu ggacaugugg     2280

agcgugggcg ugaucaucua cgugagccug agcggcaccu uccccuucaa cgaggacgag     2340

gacaucaacg accagaucca gaacgccgcc uucauguacc cccccaaccc cuggagagag     2400

aucagcggcg aggccaucga ccugaucaac aaccugcugc aggugaagau gagaaagaga     2460

uacagcgugg acaagagccu gagccacccc uggcugcagg acuaccagac cuggcuggac     2520

cugagagagu ucgagaccag aaucggcgag agauacauca cccacgagag cgacgacgcc     2580

agaugggaga uccacgccua cacccacaac cugguguacc ccaagcacuu caucauggcc     2640

cccaaccccg acgacaugga ggaggacccc uga                                  2673


<210>  8870
<211>  2673
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCD3__Homo_sapiens__AAY14817

<400>  8870
augagcgcca acaauucccc ucccucugcu cagaagucug ugcugccgac cgccaucccc       60

gcgguccucc cugcugccuc ccccugcucu agcccuaaaa caggccuguc cgccagacuu      120

ucuaacggga gcuucuccgc ucccagccug acgaauagcc ggggauccgu ucacaccgug      180

agcuuucucc ugcaaauugg ccuuacacgc gagucuguga ccaucgaagc ccaggagcug      240

ucccucagcg cugucaagga ccuggugugu ucuauuguuu accagaaauu cccugaaugc      300

ggguuuuucg gaauguauga uaagauccug cucuuuagac augacaugaa cuccgagaau      360

auucugcagc uuaucacaag cgccgaugaa auccacgagg gcgaccuggu ggaggucgug      420

cucuccgcgc uggccaccgu ugaagauuuc caaauucggc cgcauacacu uuacgugcac      480

ucuuauaaag cucccaccuu uugugacuac ugcggggaga ugcugugggg acucguccgc      540

cagggccuga agugugaagg cugcgggcug aacuaucaua agagaugugc cuucaaaauc      600

ccuaauaacu gcagcggagu gcggaagcgc agacucucca augugagccu gcccggcccu      660

gggcuuucug ucccccggcc gcugcagccu gaguacguug cucuccccuc cgaggaaagc      720

cacgugcacc aggagccuuc uaaacgcauu cccagcuggu ccggaagacc caucuggaug      780

gaaaagaugg ugaugugucg ggucaaagug ccucauacgu uugccguuca cucuuauacc      840

cgcccgacaa uuugccaaua cuguaagaga cugcuuaagg gccuguuccg gcaggggaug      900

cagugcaaag auugcaaguu uaacugucau aaacgcugcg cgagcaaggu gcccagagac      960

ugucucggag aggucaccuu caauggcgaa ccuuccagcc ugggcacaga uaccgacauc     1020

cccauggaua uugacaacaa ugauaucaac ucugacucca gccgggggcu ggacgauacg     1080

gaggagccuu cucccccgga agacaaaaug uuuuuccucg auccuuccga ccuggaugug     1140

gagagagacg aagaggccgu uaagacaauc agccccucca ccucuaauaa cauuccucuu     1200

augcgcgugg uccagagcau caaacacaca aagcggaagu ccucuaccau ggugaaagaa     1260

ggauggaugg uccacuacac cagcagagau aaccugcgca agcggcauua uuggagacuc     1320

gacuccaaau gccugacacu uuuccaaaau gagagcggcu cuaaguacua uaaagagauu     1380

ccccuguccg aaauccuccg cauuagcucu ccucgggauu uuacgaacau cucccagggg     1440

agcaaucccc acuguuucga gaucauuacc gacacaaugg uguacuuugu uggagaaaac     1500

aauggcgauu cuagccauaa cccggugcug gcugccaccg gggucggacu ggacguggcu     1560

caguccuggg agaaggccau cagacaagcc cucaugccug uuacacccca ggcuagcgug     1620

ugcaccucuc ccggccaggg caaggaccac aaagaucugu ccacgagcau uuccgucucu     1680

aauugucaga uccaagaaaa cguggacauu agcacagugu aucagaucuu cgcggaugag     1740

guucuugggu ccggacaguu uggcaucguc uacgggggaa agcaucgcaa aaccggccgg     1800

gacguggcca uuaaggugau cgauaaaaug agauucccua ccaagcagga gucucaacug     1860

cgcaaugaag ucgcuauucu ccagaaccug caccacccgg ggaucgugaa ucuggagugc     1920

auguuugaaa cacccgagcg gguuuucgug gucauggaga aacuucaugg cgacaugcuc     1980

gaaaugauuc ugagcuccga gaagucuaga cugccugaac ggaucaccaa guuuauggug     2040

acacagauuc ucguugcccu gcgcaaccuu cacuucaaaa auaucgugca uugugaucug     2100

aagcccgaga acguccuccu ggccagcgcu gaaccuuuuc cccaggugaa acugugcgac     2160

uucggauuug ccagaaucau uggcgagaag uccuuccgga gaagcguugu ggggacgccu     2220

gcguaucuug cucccgaggu ccuccgcucu aagggauaca aucggucccu ggauaugugg     2280

agcgugggcg ugaucauuua cgucucucug uccgggaccu ucccguuuaa cgaagacgag     2340

gauaucaacg accaaauuca gaaugccgcc uucauguauc cucccaaccc uuggagagaa     2400

aucagcggag aggcuaucga ucucauuaau aaccugcuuc agguuaaaau gcgcaagaga     2460

uacucugugg acaaaucccu gagccacccc uggcuccagg acuaucaaac auggcuggau     2520

cugcgggaau uugagacccg caucggcgag agauacauua cacacgaauc cgacgaugcc     2580

cggugggaga uccaugcuua uacccacaau cuuguguacc cgaagcauuu cauuauggcc     2640

ccuaaccccg acgauaugga agaggacccu uga                                  2673


<210>  8871
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCD__Homo_sapiens__Q05655

<400>  8871

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  8872
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCD__Homo_sapiens__AAA03175

<400>  8872
auggcgccgu uccugcgcau cgccuucaac uccuaugagc ugggcucccu gcaggccgag       60

gacgaggcga accagcccuu cugugccgug aagaugaagg aggcgcucag cacagagcgu      120

gggaaaacac uggugcagaa gaagccgacc auguauccug aguggaaguc gacguucgau      180

gcccacaucu augaggggcg cgucauccag auugugcuaa ugcgggcagc agaggagcca      240

gugucugagg ugaccguggg ugugucggug cuggccgagc gcugcaagaa gaacaauggc      300

aaggcugagu ucuggcugga ccugcagccu caggccaagg uguugauguc uguucaguau      360

uuccuggagg acguggauug caaacagucu augcgcagug aggacgaggc caaguuccca      420

acgaugaacc gccgcggagc caucaaacag gccaaaaucc acuacaucaa gaaccaugag      480

uuuaucgcca ccuucuuugg gcaacccacc uucuguucug ugugcaaaga cuuugucugg      540

ggccucaaca agcaaggcua caaaugcagg caauguaacg cugccaucca caagaaaugc      600

aucgacaaga ucaucggcag augcacuggc accgcggcca acagccggga cacuauauuc      660

cagaaagaac gcuucaacau cgacaugccg caccgcuuca agguucacaa cuacaugagc      720

cccaccuucu gugaccacug cggcagccug cucuggggac uggugaagca gggauuaaag      780

ugugaagacu gcggcaugaa ugugcaccau aaaugccggg agaagguggc caaccucugc      840

ggcaucaacc agaagcuuuu ggcugaggcc uugaaccaag ucacccagag agccucccgg      900

agaucagacu cagccuccuc agagccuguu gggauauauc aggguuucga gaagaagacc      960

ggaguugcug gggaggacau gcaagacaac agugggaccu acggcaagau cugggagggc     1020

agcagcaagu gcaacaucaa caacuucauc uuccacaagg uccugggcaa aggcagcuuc     1080

gggaaggugc ugcuuggaga gcugaagggc agaggagagu acuuugccau caaggcccuc     1140

aagaaggaug ugguccugau cgacgacgac guggagugca ccaugguuga gaagcgggug     1200

cugacacuug ccgcagagaa ucccuuucuc acccaccuca ucugcaccuu ccagaccaag     1260

gaccaccugu ucuuugugau ggaguuccuc aacggggggg accugaugua ccacauccag     1320

gacaaaggcc gcuuugaacu cuaccgugcc acguuuuaug ccgcugagau aaugugugga     1380

cugcaguuuc uacacagcaa gggcaucauu uacagggacc ucaaacugga caaugugcug     1440

uuggaccggg auggccacau caagauugcc gacuuuggga ugugcaaaga gaacauauuc     1500

ggggagagcc gggccagcac cuucugcggc accccugacu auaucgcccc ugagauccua     1560

cagggccuga aguacacauu cucuguggac ugguggucuu ucgggguccu ucuguacgag     1620

augcucauug gccagucccc cuuccauggu gaugaugagg augaacucuu cgaguccauc     1680

cguguggaca cgccacauua uccccgcugg aucaccaagg aguccaagga cauccuggag     1740

aagcucuuug aaagggaacc aaccaagagg cugggaguga cgggaaacau caaaauccac     1800

cccuucuuca agaccauaaa cuggacucug cuggaaaagc ggagguugga gccacccuuc     1860

aggcccaaag ugaagucacc cagagacuac aguaacuuug accaggaguu ccugaacgag     1920

aaggcgcgcc ucuccuacag cgacaagaac cucaucgacu ccauggacca gucugcauuc     1980

gcuggcuucu ccuuugugaa ccccaaauuc gagcaccucc uggaagauug a              2031


<210>  8873
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCD__Homo_sapiens__AAA03175

<400>  8873
auggcccccu uccugcgcau cgccuucaac agcuacgagc ucggcucccu gcaggcggag       60

gacgaggcca accagcccuu cugcgccgug aagaugaagg aggcccugag caccgagcgg      120

gggaagaccc ucguccagaa gaagcccacg auguaccccg aguggaaguc caccuucgac      180

gcccacaucu acgagggccg cgugauccag aucgugcuga ugcgggcggc cgaggagccc      240

gucagcgagg ugaccguggg ggucuccgug cuggccgagc gcugcaagaa gaacaacggc      300

aaggccgagu ucuggcucga ccugcagccg caggcgaagg ugcugaugag cguccaguac      360

uuccucgagg acguggacug caagcagucc augcggagcg aggacgaggc caaguucccc      420

accaugaacc gccgcggggc caucaagcag gccaagaucc acuacaucaa gaaccacgag      480

uucaucgcca cguucuucgg ccagcccacc uucugcuccg ugugcaagga cuucgucugg      540

ggccugaaca agcaggggua caagugccgg cagugcaacg cggccaucca caagaagugc      600

aucgacaaga ucaucggccg gugcaccggg accgccgcca acagccgcga cacgaucuuc      660

cagaaggagc gguucaacau cgacaugccc caccgcuuca aggugcacaa cuacaugucc      720

ccgaccuucu gcgaccacug cggcagccug cucugggggc uggugaagca gggccugaag      780

ugcgaggacu gcggcaugaa cguccaccac aagugccggg agaagguggc caaccucugc      840

gggaucaacc agaagcugcu ggcggaggcc cucaaccagg ugacccagcg cgccucccgg      900

cgcagcgacu ccgccagcuc cgagcccguc ggcaucuacc agggguucga gaagaagacc      960

ggcguggccg gcgaggacau gcaggacaac agcgggacgu acggcaagau cugggagggg     1020

uccagcaagu gcaacaucaa caacuucauc uuccacaagg ugcugggcaa ggggagcuuc     1080

ggcaaggucc ugcucggcga gcugaagggg cggggcgagu acuucgcgau caaggcccug     1140

aagaaggacg uggugcucau cgacgacgac gucgagugca ccauggugga gaagcgcguc     1200

cugacccugg ccgccgagaa ccccuuccuc acccaccuga ucugcacguu ccagaccaag     1260

gaccaccugu ucuucgugau ggaguuccuc aacgggggcg accugaugua ccacauccag     1320

gacaaggggc gguucgagcu guaccgcgcc accuucuacg cggccgagau caugugcggc     1380

cuccaguucc ugcacuccaa gggcaucauc uaccgggacc ugaagcucga caacgugcug     1440

cuggaccgcg acgggcacau caagaucgcc gacuucggca ugugcaagga gaacaucuuc     1500

ggggagagcc gcgccuccac cuucugcggc acgcccgacu acaucgcgcc ggagauccuc     1560

caggggcuga aguacaccuu cagcgucgac uggugguccu ucggcgugcu gcucuacgag     1620

augcugaucg gccagagccc cuuccacggg gacgacgagg acgagcuguu cgaguccauc     1680

cggguggaca cgccccacua cccccgcugg aucaccaagg agagcaagga cauccucgag     1740

aagcuguucg agcgggagcc gaccaagcgc cugggcguca ccgggaacau caagauccac     1800

cccuucuuca agaccaucaa cuggacccuc cuggagaagc ggcgccugga gccgcccuuc     1860

cggcccaagg ugaagucccc gcgcgacuac agcaacuucg accaggaguu ccugaacgag     1920

aaggcccggc ucuccuacag cgacaagaac cugaucgacu ccauggacca gagcgccuuc     1980

gccggcuucu ccuucgugaa ccccaaguuc gagcaccucc uggaggacug a              2031


<210>  8874
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCD__Homo_sapiens__AAA03175

<400>  8874
auggcccccu uccuccgcau cgccuucaac uccuacgagc ucggcucccu ccaggccgag       60

gacgaggcca accagcccuu cugcgccguc aagaugaagg aggcccucuc caccgagcgc      120

ggcaagaccc ucguccagaa gaagcccacc auguaccccg aguggaaguc caccuucgac      180

gcccacaucu acgagggccg cgucauccag aucguccuca ugcgcgccgc cgaggagccc      240

gucuccgagg ucaccgucgg cgucuccguc cucgccgagc gcugcaagaa gaacaacggc      300

aaggccgagu ucuggcucga ccuccagccc caggccaagg uccucauguc cguccaguac      360

uuccucgagg acgucgacug caagcagucc augcgcuccg aggacgaggc caaguucccc      420

accaugaacc gccgcggcgc caucaagcag gccaagaucc acuacaucaa gaaccacgag      480

uucaucgcca ccuucuucgg ccagcccacc uucugcuccg ucugcaagga cuucgucugg      540

ggccucaaca agcagggcua caagugccgc cagugcaacg ccgccaucca caagaagugc      600

aucgacaaga ucaucggccg cugcaccggc accgccgcca acucccgcga caccaucuuc      660

cagaaggagc gcuucaacau cgacaugccc caccgcuuca agguccacaa cuacaugucc      720

cccaccuucu gcgaccacug cggcucccuc cucuggggcc ucgucaagca gggccucaag      780

ugcgaggacu gcggcaugaa cguccaccac aagugccgcg agaaggucgc caaccucugc      840

ggcaucaacc agaagcuccu cgccgaggcc cucaaccagg ucacccagcg cgccucccgc      900

cgcuccgacu ccgccuccuc cgagcccguc ggcaucuacc agggcuucga gaagaagacc      960

ggcgucgccg gcgaggacau gcaggacaac uccggcaccu acggcaagau cugggagggc     1020

uccuccaagu gcaacaucaa caacuucauc uuccacaagg uccucggcaa gggcuccuuc     1080

ggcaaggucc uccucggcga gcucaagggc cgcggcgagu acuucgccau caaggcccuc     1140

aagaaggacg ucguccucau cgacgacgac gucgagugca ccauggucga gaagcgcguc     1200

cucacccucg ccgccgagaa ccccuuccuc acccaccuca ucugcaccuu ccagaccaag     1260

gaccaccucu ucuucgucau ggaguuccuc aacggcggcg accucaugua ccacauccag     1320

gacaagggcc gcuucgagcu cuaccgcgcc accuucuacg ccgccgagau caugugcggc     1380

cuccaguucc uccacuccaa gggcaucauc uaccgcgacc ucaagcucga caacguccuc     1440

cucgaccgcg acggccacau caagaucgcc gacuucggca ugugcaagga gaacaucuuc     1500

ggcgaguccc gcgccuccac cuucugcggc acccccgacu acaucgcccc cgagauccuc     1560

cagggccuca aguacaccuu cuccgucgac uggugguccu ucggcguccu ccucuacgag     1620

augcucaucg gccagucccc cuuccacggc gacgacgagg acgagcucuu cgaguccauc     1680

cgcgucgaca ccccccacua cccccgcugg aucaccaagg aguccaagga cauccucgag     1740

aagcucuucg agcgcgagcc caccaagcgc cucggcguca ccggcaacau caagauccac     1800

cccuucuuca agaccaucaa cuggacccuc cucgagaagc gccgccucga gccccccuuc     1860

cgccccaagg ucaagucccc ccgcgacuac uccaacuucg accaggaguu ccucaacgag     1920

aaggcccgcc ucuccuacuc cgacaagaac cucaucgacu ccauggacca guccgccuuc     1980

gccggcuucu ccuucgucaa ccccaaguuc gagcaccucc ucgaggacug a              2031


<210>  8875
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCD__Homo_sapiens__AAA03175

<400>  8875
auggcccccu uccugagaau cgcuuuuaac agcuacgagc ucggcucccu ucaggcagaa       60

gacgaggcca aucaaccuuu cugcgcggug aagaugaaag aagcucuguc uaccgagagg      120

gggaagacau ugguccagaa aaagccaacu auguauccgg aauggaaauc aacguuugau      180

gcccacauuu acgagggacg gguuauacag aucguguuaa ugcgcgcagc cgaggaaccc      240

guaagugagg ugaccgucgg ugugagcguu cuggcugaac gauguaagaa gaacaauggc      300

aaagcagagu ucuggcuaga ccuccagccu caagccaagg ugcugauguc cguccaguau      360

uuucuugagg auguggacug caaacagucu augcguucgg aagaugaggc uaaguuccca      420

acaaugaaca gaaggggagc cauuaaacag gcgaagaucc auuacauuaa gaaucacgaa      480

uuuaucgcaa cuuucuuugg gcaacccacc uucuguucag uaugcaaaga cuuuguuugg      540

ggccugaaca agcaggguua uaaaugucgg cagugcaaug ccgcuauaca uaagaaaugu      600

aucgauaaga uuaucgggcg cugcacagga accgccgcaa acagcagaga cacuauuuuc      660

cagaaagaga gguuuaauau cgauaugccu caccgguuca aggugcauaa cuacaugagu      720

ccaacauucu gugaccacug cggcuccuug cucuggggcc uggucaagca agggcugaaa      780

ugugaagauu gcggaaugaa ugugcaccau aagugccgcg agaaaguggc uaaccucugu      840

gguauaaauc agaaguuacu ggccgaggcg cuuaaccagg ucacccaacg agccucuaga      900

aggagcgacu ccgcaucaag ugaacccguu ggcauuuauc agggguuuga gaaaaagacg      960

ggaguggcug gcgaagauau gcaggacaau agcgguacuu acgggaagau cugggaggga     1020

ucuuccaaau gcaacauuaa caauuucauc uuucacaagg uauugggcaa aggcucauuc     1080

gggaaggugc ugcuaggaga acucaaaggu cggggcgagu acuuugccau caaggcucug     1140

aagaaagacg ucgugcuuau ugaugacgau guugagugua ccauggugga aaagcguguc     1200

cugacauugg ccgcagagaa cccuuuccuc acucaucuga uaugcaccuu ucagacaaaa     1260

gaccacuuau ucuuugugau ggaauuucug aaugggggag aucucaugua ucacauccaa     1320

gacaagggcc gcuuugagcu uuacagagcc accuucuaug cugcggaaau uauguguggu     1380

cugcaguuuu ugcauagcaa agggaucaua uacagggauc uaaagcugga caacguacuc     1440

cuggaucggg acggccacau uaagaucgca gauuucggaa ugugcaaaga gaauaucuuc     1500

ggcgagaguc gagccucuac guuuuguggg acuccagacu auauugcucc ggaaauccuu     1560

cagggacuga aguacacauu cuccguugac ugguggagcu uugguguguu gcucuaugag     1620

augcugauug gccagucgcc cuuccauggg gaugacgaag augaguuauu ugagucuaua     1680

cgcgucgaca ccccucacua cccaagaugg aucacuaaag aauccaagga uauucuggag     1740

aaacuauucg aaagggagcc cacaaagcgg cucggaguga ccggcaacau caaaauccau     1800

ccuuucuuca agacgauuaa uuggacccug cuugaaaagc gcagauugga gccacccuuu     1860

aggccgaaag ucaagucacc ucgugacuac aguaacuucg aucaagaguu ucugaaugaa     1920

aaagcccggc ucagcuauuc cgacaagaac cugauagauu cuauggacca gagcgcauuc     1980

gccgguuuuu cauucgugaa ucccaaauuc gagcaccuuc uggaagauug a              2031


<210>  8876
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCD__Homo_sapiens__AAA03175

<400>  8876
auggcccccu uccugagaau cgccuucaac agcuacgagc ugggcagccu gcaggccgag       60

gacgaggcca accagcccuu cugcgccgug aagaugaagg aggcccugag caccgagaga      120

ggcaagaccc uggugcagaa gaagcccacc auguaccccg aguggaagag caccuucgac      180

gcccacaucu acgagggcag agugauccag aucgugcuga ugagagccgc cgaggagccc      240

gugagcgagg ugaccguggg cgugagcgug cuggccgaga gaugcaagaa gaacaacggc      300

aaggccgagu ucuggcugga ccugcagccc caggccaagg ugcugaugag cgugcaguac      360

uuccuggagg acguggacug caagcagagc augagaagcg aggacgaggc caaguucccc      420

accaugaaca gaagaggcgc caucaagcag gccaagaucc acuacaucaa gaaccacgag      480

uucaucgcca ccuucuucgg ccagcccacc uucugcagcg ugugcaagga cuucgugugg      540

ggccugaaca agcagggcua caagugcaga cagugcaacg ccgccaucca caagaagugc      600

aucgacaaga ucaucggcag augcaccggc accgccgcca acagcagaga caccaucuuc      660

cagaaggaga gauucaacau cgacaugccc cacagauuca aggugcacaa cuacaugagc      720

cccaccuucu gcgaccacug cggcagccug cuguggggcc uggugaagca gggccugaag      780

ugcgaggacu gcggcaugaa cgugcaccac aagugcagag agaagguggc caaccugugc      840

ggcaucaacc agaagcugcu ggccgaggcc cugaaccagg ugacccagag agccagcaga      900

agaagcgaca gcgccagcag cgagcccgug ggcaucuacc agggcuucga gaagaagacc      960

ggcguggccg gcgaggacau gcaggacaac agcggcaccu acggcaagau cugggagggc     1020

agcagcaagu gcaacaucaa caacuucauc uuccacaagg ugcugggcaa gggcagcuuc     1080

ggcaaggugc ugcugggcga gcugaagggc agaggcgagu acuucgccau caaggcccug     1140

aagaaggacg uggugcugau cgacgacgac guggagugca ccauggugga gaagagagug     1200

cugacccugg ccgccgagaa ccccuuccug acccaccuga ucugcaccuu ccagaccaag     1260

gaccaccugu ucuucgugau ggaguuccug aacggcggcg accugaugua ccacauccag     1320

gacaagggca gauucgagcu guacagagcc accuucuacg ccgccgagau caugugcggc     1380

cugcaguucc ugcacagcaa gggcaucauc uacagagacc ugaagcugga caacgugcug     1440

cuggacagag acggccacau caagaucgcc gacuucggca ugugcaagga gaacaucuuc     1500

ggcgagagca gagccagcac cuucugcggc acccccgacu acaucgcccc cgagauccug     1560

cagggccuga aguacaccuu cagcguggac ugguggagcu ucggcgugcu gcuguacgag     1620

augcugaucg gccagagccc cuuccacggc gacgacgagg acgagcuguu cgagagcauc     1680

agaguggaca ccccccacua ccccagaugg aucaccaagg agagcaagga cauccuggag     1740

aagcuguucg agagagagcc caccaagaga cugggcguga ccggcaacau caagauccac     1800

cccuucuuca agaccaucaa cuggacccug cuggagaaga gaagacugga gccccccuuc     1860

agacccaagg ugaagagccc cagagacuac agcaacuucg accaggaguu ccugaacgag     1920

aaggccagac ugagcuacag cgacaagaac cugaucgaca gcauggacca gagcgccuuc     1980

gccggcuuca gcuucgugaa ccccaaguuc gagcaccugc uggaggacug a              2031


<210>  8877
<211>  2031
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCD__Homo_sapiens__AAA03175

<400>  8877
auggcccccu uccugagaau cgcuuuuaac agcuacgagc ucggcucccu gcaggccgaa       60

gacgaggcga aucaaccuuu cugcgcugug aagaugaaag aagcccuuuc uaccgagcgg      120

gggaagacac ugguccagaa aaagccgacg auguaucccg aauggaaaag caccuuugau      180

gcccacauuu acgagggacg cguuauccag auugugcuca ugagagcugc cgaggaaccu      240

guguccgagg ucacaguggg cguuucugug cuggcugaac gguguaagaa gaacaauggg      300

aaagccgagu ucuggcuuga ccugcagccc caagcgaagg uccucaugag cgugcaguau      360

uuucuggagg auguugacug caaacagucc augcgcucug aagaugaggc caaguucccu      420

accaugaaca gacggggagc uaucaaacag gccaagauuc acuacaucaa gaaucacgaa      480

uuuaucgcua cauucuuugg ccaacccacc uucuguagcg ugugcaaaga cuuugucugg      540

gggcugaaca agcagggaua uaaaugucgc cagugcaaug ccgcgauuca uaagaaaugu      600

aucgauaaga uuaucggcag augcacaggc accgccgcua acucccggga cacgauuuuc      660

cagaaagagc gcuuuaauau cgauaugccu cacagauuca aggugcauaa cuacaugagc      720

ccgaccuucu gugaccacug cgggucucuc cuguggggac uugugaagca aggccugaaa      780

ugugaagauu gcgggaugaa uguccaccau aagugccggg agaaaguugc caaccucugu      840

ggaauuaauc agaagcugcu ugcugaggcc cugaaccagg ugacacaacg cgccuccaga      900

cggagcgacu cugcuuccag cgaacccgug ggcaucuauc agggguuuga gaaaaagacc      960

ggagucgcgg gcgaagauau gcaggacaau ucuggcacau acgggaagau cugggaggga     1020

uccagcaaau gcaacauuaa caauuucauc uuucacaagg ugcucggcaa aggguccuuc     1080

ggaaagguuc ugcugggcga acucaaaggg cgcggagagu acuuugccau uaaggcucug     1140

aagaaagacg ugguccuuau cgaugacgau guggagugua ccaugguuga aaagagagug     1200

cugacgcucg ccgccgagaa cccuuuccug acacaucuua uuugcaccuu ucagacaaaa     1260

gaccaccugu ucuuugucau ggaguuccuc aauggcggcg aucugaugua ucacauccaa     1320

gacaaggggc gguuugaacu guacagagcu accuucuaug ccgcggaaau caugugugga     1380

cuccaguuuc ugcauucuaa aggcauuauc uaccgcgauc uuaagcugga caacgugcuc     1440

cuggaucggg acgggcacau uaagaucgcu gauuucggaa ugugcaaaga gaauauuuuc     1500

ggcgagagca gagccuccac cuuuuguggg acacccgacu auaucgcccc ugaaauccuu     1560

cagggccuga aguacacguu cagcgucgac ugguggucuu uuggagugcu ccuguaugag     1620

augcugauug gccagucccc cuuccauggg gaugacgaag augagcucuu ugagagcauc     1680

cgcguugaca ccccgcacua cccucggugg auuacaaaag aaucuaagga uauccuggag     1740

aaacuuuucg aaagagagcc caccaagcgc cugggaguga caggcaacau uaaaauccau     1800

cccuuuuuca agaccauuaa uuggacgcuc cuggaaaagc ggagacugga gccucccuuu     1860

cgcccuaaag ucaagagccc gcgggacuac uccaacuucg aucaagaguu ucuuaaugaa     1920

aaagcuagac ucucuuauag cgacaagaac cugaucgauu ccauggacca gagcgccuuc     1980

gcuggguuuu cuuucgugaa ucccaaauuc gagcaucugc ucgaagauug a              2031


<210>  8878
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCE__Homo_sapiens__Q02156

<400>  8878

Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val 
1               5                   10                  15      


Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg 
            20                  25                  30          


Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp 
        35                  40                  45              


Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala 
    50                  55                  60                  


Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu 
65                  70                  75                  80  


Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala 
                85                  90                  95      


Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His 
            100                 105                 110         


Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile 
        115                 120                 125             


Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu 
    130                 135                 140                 


Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val 
145                 150                 155                 160 


Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr 
                165                 170                 175     


Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly 
            180                 185                 190         


Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val 
        195                 200                 205             


His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys 
    210                 215                 220                 


Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn 
225                 230                 235                 240 


Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys 
                245                 250                 255     


Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln 
            260                 265                 270         


Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val 
        275                 280                 285             


Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala 
    290                 295                 300                 


Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg 
305                 310                 315                 320 


Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser 
                325                 330                 335     


Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys 
            340                 345                 350         


Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser 
        355                 360                 365             


Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly 
    370                 375                 380                 


Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala 
385                 390                 395                 400 


Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys 
                405                 410                 415     


Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu 
            420                 425                 430         


Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp 
        435                 440                 445             


Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg 
    450                 455                 460                 


Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp 
465                 470                 475                 480 


Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe 
                485                 490                 495     


Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr 
            500                 505                 510         


Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val 
        515                 520                 525             


Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly 
    530                 535                 540                 


His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn 
545                 550                 555                 560 


Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro 
                565                 570                 575     


Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala 
            580                 585                 590         


Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu 
        595                 600                 605             


Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val 
    610                 615                 620                 


Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala 
625                 630                 635                 640 


Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln 
                645                 650                 655     


Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp 
            660                 665                 670         


Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg 
        675                 680                 685             


Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg 
    690                 695                 700                 


Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile 
705                 710                 715                 720 


Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met 
                725                 730                 735     


Pro 
    


<210>  8879
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCE__Homo_sapiens__AAI09034

<400>  8879
augguagugu ucaauggccu ucuuaagauc aaaaucugcg aggccgugag cuugaagccc       60

acagccuggu cgcugcgcca ugcgguggga ccccggccgc agacuuuccu ucucgacccc      120

uacauugccc ucaaugugga cgacucgcgc aucggccaaa cggccaccaa gcagaagacc      180

aacagcccgg ccuggcacga cgaguucguc accgaugugu gcaacggacg caagaucgag      240

cuggcugucu uucacgaugc ccccauaggc uacgacgacu ucguggccaa cugcaccauc      300

caguuugagg agcugcugca gaacgggagc cgccacuucg aggacuggau ugaucuggag      360

ccagaaggaa gaguguaugu gaucaucgau cucucagggu cgucggguga agccccuaaa      420

gacaaugaag agcguguguu cagggaacgc augcggccga ggaagcggca gggggccguc      480

aggcgcaggg uccaucaggu caacggccac aaguucaugg ccaccuaucu ucggcagccc      540

accuacugcu cccauugcag agacuucauc ugggguguca uaggaaagca gggauaccag      600

ugucaagucu gcaccugcgu gguccacaag cggugccacg agcucauaau cacaaagugu      660

gcuggguuaa agaagcagga gacccccgac caggugggcu cccagcgguu cagcgucaac      720

augccccaca aguucgguau ccacaacuac aaggucccua ccuucugcga ucacuguggg      780

ucccugcucu ggggacucuu gcggcagggu uugcagugua aagucugcaa aaugaauguu      840

caccgucgau gugagaccaa cguggcuccc aacuguggag uggaugccag aggaaucgcc      900

aaaguacugg ccgaccuggg cguuacccca gacaaaauca ccaacagcgg ccagagaagg      960

aaaaagcuca uugcuggugc cgaguccccg cagccugcuu cuggaagcuc accaucugag     1020

gaagaucgau ccaagucagc acccaccucc ccuugugacc aggaaauaaa agaacuugag     1080

aacaacauuc ggaaagccuu gucauuugac aaccgaggag aggagcaccg ggcagcaucg     1140

ucuccugaug gccagcugau gagccccggu gagaauggcg aaguccggca aggccaggcc     1200

aagcgccugg gccuggauga guucaacuuc aucaaggugu ugggcaaagg cagcuuuggc     1260

aaggucaugu uggcagaacu caagggcaaa gaugaaguau augcugugaa ggucuuaaag     1320

aaggacguca uccuucagga ugaugacgug gacugcacaa ugacagagaa gaggauuuug     1380

gcucuggcac ggaaacaccc guaccuuacc caacucuacu gcugcuucca gaccaaggac     1440

cgccucuuuu ucgucaugga auauguaaau gguggagacc ucauguuuca gauucagcgc     1500

ucccgaaaau ucgacgagcc ucguucacgg uucuaugcug cagaggucac aucggcccuc     1560

auguuccucc accagcaugg agucaucuac agggauuuga aacuggacaa cauccuucug     1620

gaugcagaag gucacugcaa gcuggcugac uucgggaugu gcaaggaagg gauucugaau     1680

ggugugacga ccaccacguu cugugggacu ccugacuaca uagcuccuga gauccugcag     1740

gaguuggagu auggccccuc cguggacugg ugggcccugg gggugcugau guacgagaug     1800

auggcuggac agccucccuu ugaggccgac aaugaggacg accuauuuga guccauccuc     1860

caugacgacg ugcuguaccc agucuggcuc agcaaggagg cugucagcau cuugaaagcu     1920

uucaugacga agaaucccca caagcgccug ggcugugugg caucgcagaa uggcgaggac     1980

gccaucaagc agcacccauu cuucaaagag auugacuggg ugcuccugga gcagaagaag     2040

aucaagccac ccuucaaacc acgcauuaaa accaaaagag acgucaauaa uuuugaccaa     2100

gacuuuaccc gggaagagcc gguacucacc cuuguggacg aagcaauugu aaagcagauc     2160

aaccaggagg aauucaaagg uuucuccuac uuuggugaag accugaugcc cuga           2214


<210>  8880
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCE__Homo_sapiens__AAI09034

<400>  8880
augguggucu ucaacggccu gcucaagauc aagaucugcg aggccgugag ccugaagccc       60

accgccuggu cccugcgcca cgcggugggg ccgcggcccc agaccuuccu ccuggacccc      120

uacaucgccc ugaacgucga cgacagccgc aucggccaga cggccaccaa gcagaagacc      180

aacucccccg ccuggcacga cgaguucgug accgacgugu gcaacgggcg gaagaucgag      240

cucgccgucu uccacgacgc gccgaucggc uacgacgacu ucguggccaa cugcacgauc      300

caguucgagg agcugcugca gaacgggagc cgccacuucg aggacuggau cgaccucgag      360

cccgagggcc ggguguacgu caucaucgac cuguccggca gcuccgggga ggcccccaag      420

gacaacgagg agcgcguguu ccgggagcgc augcggcccc gcaagcggca gggcgccgug      480

cgccggcgcg uccaccaggu gaacgggcac aaguucaugg cgaccuaccu gcggcagccg      540

accuacugca gccacugccg cgacuucauc uggggcguga ucgggaagca gggcuaccag      600

ugccaggucu gcacgugcgu ggugcacaag cggugccacg agcucaucau caccaagugc      660

gccggccuga agaagcagga gacccccgac caggucgggu cccagcgcuu cagcgugaac      720

augccccaca aguucggcau ccacaacuac aaggugccca ccuucugcga ccacugcggg      780

ucccugcucu ggggccugcu gcggcagggc cuccagugca aggucugcaa gaugaacgug      840

caccgccggu gcgagaccaa cguggccccg aacugcgggg ucgacgcccg cggcaucgcc      900

aaggugcugg cggaccuggg ggucacgccc gacaagauca ccaacagcgg ccagcgccgg      960

aagaagcuca ucgccggggc cgagagcccc cagcccgccu ccggcuccag cccguccgag     1020

gaggaccgca gcaaguccgc ccccaccagc cccugcgacc aggagaucaa ggagcuggag     1080

aacaacaucc ggaaggcgcu gagcuucgac aaccgcggcg aggagcaccg ggccgccucc     1140

agccccgacg ggcagcucau guccccgggc gagaacgggg aggugcgcca gggccaggcc     1200

aagcggcugg ggcuggacga guucaacuuc aucaaggugc ucggcaaggg cagcuucggg     1260

aaggucaugc uggccgagcu gaagggcaag gacgaggugu acgcggugaa gguccucaag     1320

aaggacguga uccugcagga cgacgacgug gacugcacca ugacggagaa gcgcauccug     1380

gcccucgccc ggaagcaccc cuaccugacc cagcuguacu gcugcuucca gaccaaggac     1440

cgccucuucu ucgucaugga guacgugaac gggggcgacc ugauguucca gauccagcgg     1500

ucccgcaagu ucgacgagcc ccggagccgc uucuacgccg ccgaggugac cuccgcgcug     1560

auguuccucc accagcacgg ggucaucuac cgggaccuga agcuggacaa cauccuccug     1620

gacgccgagg gccacugcaa gcuggccgac uucggcaugu gcaaggaggg gauccucaac     1680

ggcgugacga ccaccaccuu cugcgggacg cccgacuaca ucgccccgga gauccugcag     1740

gagcuggagu acggccccag cguggacugg ugggcgcucg gcguccugau guacgagaug     1800

auggccgggc agccgcccuu cgaggccgac aacgaggacg accuguucga guccauccug     1860

cacgacgacg ugcucuaccc cguguggcug agcaaggagg ccgucuccau ccugaaggcc     1920

uucaugacca agaaccccca caagcgccuc ggcugcgugg cgagccagaa cggggaggac     1980

gccaucaagc agcaccccuu cuucaaggag aucgacuggg ugcugcugga gcagaagaag     2040

aucaagccgc ccuucaagcc ccggaucaag accaagcgcg acgucaacaa cuucgaccag     2100

gacuucaccc gggaggagcc cgugcucacg cugguggacg aggccaucgu caagcagauc     2160

aaccaggagg aguucaaggg cuucuccuac uucggggagg accugaugcc guga           2214


<210>  8881
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCE__Homo_sapiens__AAI09034

<400>  8881
auggucgucu ucaacggccu ccucaagauc aagaucugcg aggccgucuc ccucaagccc       60

accgccuggu cccuccgcca cgccgucggc ccccgccccc agaccuuccu ccucgacccc      120

uacaucgccc ucaacgucga cgacucccgc aucggccaga ccgccaccaa gcagaagacc      180

aacucccccg ccuggcacga cgaguucguc accgacgucu gcaacggccg caagaucgag      240

cucgccgucu uccacgacgc ccccaucggc uacgacgacu ucgucgccaa cugcaccauc      300

caguucgagg agcuccucca gaacggcucc cgccacuucg aggacuggau cgaccucgag      360

cccgagggcc gcgucuacgu caucaucgac cucuccggcu ccuccggcga ggcccccaag      420

gacaacgagg agcgcgucuu ccgcgagcgc augcgccccc gcaagcgcca gggcgccguc      480

cgccgccgcg uccaccaggu caacggccac aaguucaugg ccaccuaccu ccgccagccc      540

accuacugcu cccacugccg cgacuucauc uggggcguca ucggcaagca gggcuaccag      600

ugccaggucu gcaccugcgu cguccacaag cgcugccacg agcucaucau caccaagugc      660

gccggccuca agaagcagga gacccccgac caggucggcu cccagcgcuu cuccgucaac      720

augccccaca aguucggcau ccacaacuac aaggucccca ccuucugcga ccacugcggc      780

ucccuccucu ggggccuccu ccgccagggc cuccagugca aggucugcaa gaugaacguc      840

caccgccgcu gcgagaccaa cgucgccccc aacugcggcg ucgacgcccg cggcaucgcc      900

aagguccucg ccgaccucgg cgucaccccc gacaagauca ccaacuccgg ccagcgccgc      960

aagaagcuca ucgccggcgc cgaguccccc cagcccgccu ccggcuccuc ccccuccgag     1020

gaggaccgcu ccaaguccgc ccccaccucc cccugcgacc aggagaucaa ggagcucgag     1080

aacaacaucc gcaaggcccu cuccuucgac aaccgcggcg aggagcaccg cgccgccucc     1140

ucccccgacg gccagcucau gucccccggc gagaacggcg agguccgcca gggccaggcc     1200

aagcgccucg gccucgacga guucaacuuc aucaaggucc ucggcaaggg cuccuucggc     1260

aaggucaugc ucgccgagcu caagggcaag gacgaggucu acgccgucaa gguccucaag     1320

aaggacguca uccuccagga cgacgacguc gacugcacca ugaccgagaa gcgcauccuc     1380

gcccucgccc gcaagcaccc cuaccucacc cagcucuacu gcugcuucca gaccaaggac     1440

cgccucuucu ucgucaugga guacgucaac ggcggcgacc ucauguucca gauccagcgc     1500

ucccgcaagu ucgacgagcc ccgcucccgc uucuacgccg ccgaggucac cuccgcccuc     1560

auguuccucc accagcacgg cgucaucuac cgcgaccuca agcucgacaa cauccuccuc     1620

gacgccgagg gccacugcaa gcucgccgac uucggcaugu gcaaggaggg cauccucaac     1680

ggcgucacca ccaccaccuu cugcggcacc cccgacuaca ucgcccccga gauccuccag     1740

gagcucgagu acggccccuc cgucgacugg ugggcccucg gcguccucau guacgagaug     1800

auggccggcc agccccccuu cgaggccgac aacgaggacg accucuucga guccauccuc     1860

cacgacgacg uccucuaccc cgucuggcuc uccaaggagg ccgucuccau ccucaaggcc     1920

uucaugacca agaaccccca caagcgccuc ggcugcgucg ccucccagaa cggcgaggac     1980

gccaucaagc agcaccccuu cuucaaggag aucgacuggg uccuccucga gcagaagaag     2040

aucaagcccc ccuucaagcc ccgcaucaag accaagcgcg acgucaacaa cuucgaccag     2100

gacuucaccc gcgaggagcc cguccucacc cucgucgacg aggccaucgu caagcagauc     2160

aaccaggagg aguucaaggg cuucuccuac uucggcgagg accucaugcc cuga           2214


<210>  8882
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCE__Homo_sapiens__AAI09034

<400>  8882
augguggucu ucaacggccu gcucaagauc aaaauuugcg aggccguuag ccuuaagccc       60

accgcuuggu cccugagaca cgcagugggg ccuaggccac agacauuuuu guuagacccg      120

uacauagccc ugaauguaga ugacucucgg aucggacaaa cugcgacgaa acagaagacc      180

aacucacccg cuuggcauga ugaguucgug acagacgucu guaauggucg caaaauugag      240

cuagccgugu uucacgaugc accuaucggc uaugacgauu ucguugccaa cugcacuauu      300

caguuugaag aacuccugca gaaugggagu cgacauuucg aagacuggau cgaucuugag      360

ccagagggac guguguacgu cauaaucgac cugagcggcu ccucugguga agcucccaag      420

gauaacgagg aaagaguguu uagggagcgg augcgcccua gaaagaggca aggggcagua      480

cggcgccgag uucaccaggu gaauggacau aaauucaugg ccaccuauuu gagacagcca      540

acauacuguu cgcacugcag ggacuuuauu uggggcguca ucggcaagca gggguaucaa      600

ugucaggugu gcaccugugu gguccacaaa cggugccaug agcucauuau cacuaagugu      660

gcuggacuga aaaagcagga aacacccgau cagguugguu cacaacguuu cagcgugaac      720

augccucaca aguuuggcau acauaauuac aaaguaccaa ccuucugcga ccacuguggg      780

agucugcucu ggggauuacu gcgccagggc cuucagugca aggugugcaa aaugaacguc      840

cacagaaggu gugagacgaa uguggccccg aacugcggug uugacgcgcg ggggauugca      900

aagguguugg ccgaucuggg agucacuccc gacaaaauca ccaauuccgg ccaacgacgc      960

aagaaacuaa uugcuggcgc cgaaucuccu cagccagcaa gcggguccuc acccagugag     1020

gaagauagaa gcaagucugc uccuacaucc ccaugugacc aggagaucaa ggagcucgaa     1080

aacaauauca ggaaagcccu gucauuugau aaccggggag aggaacaucg cgcggccagc     1140

agucccgacg gucagcuuau gucuccgggc gagaacgggg aagugagaca aggacaggca     1200

aagaggcugg gcuuggauga guucaauuuc auuaaaguac ucgguaaggg guccuuuggc     1260

aaaguuaugc uggcugaguu aaagggaaag gacgaagugu augccgucaa agugcugaag     1320

aaagauguca uacuccagga cgaugacgug gacugcacua ugaccgagaa gcguauccuu     1380

gcucuggccc ggaaacaccc uuacuugaca cagcuauacu guugcuucca aaccaaggau     1440

cgacuguuuu ucguuaugga auaugugaac ggcggggacc ucauguuuca gauucagaga     1500

agcaggaagu ucgaugagcc ccgcucgcgg uuuuacgcag ccgaaguaac gucugcucug     1560

auguuccuuc aucagcacgg agucaucuau agagaccuga aauuggauaa uauacuccug     1620

gacgcggagg gucauuguaa guuagcagau uuuggcaugu gcaaagaggg gauucugaac     1680

ggagugacua caaccacuuu cuguggcaca ccagacuaca ucgccccuga aauccuacaa     1740

gagcucgaau auggucccuc cguugauugg ugggcucugg gggugcuuau guacgagaug     1800

auggccggcc agccacccuu ugaggcagac aaugaagaug acuuguucga gucaauucug     1860

cacgaugacg uccucuaucc uguguggcug aguaaggaag ccguaagcau ccuuaaggcu     1920

uuuaugacca aaaacccaca caagaggcug ggaugcgugg ccucccagaa uggcgaggac     1980

gcaauuaaac agcauccguu cuucaaggaa auagauuggg uuuugcucga gcagaaaaag     2040

aucaaacccc cuuuuaagcc acgcauuaaa acgaagcgag acgucaacaa uuucgaucaa     2100

gacuuuaccc gggaggaacc cgugcugaca uuaguggaug aggcgaucgu caagcagauc     2160

aaccaagaag aguucaaagg guuuucuuac uucggagaag accugaugcc uuga           2214


<210>  8883
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCE__Homo_sapiens__AAI09034

<400>  8883
augguggugu ucaacggccu gcugaagauc aagaucugcg aggccgugag ccugaagccc       60

accgccugga gccugagaca cgccgugggc cccagacccc agaccuuccu gcuggacccc      120

uacaucgccc ugaacgugga cgacagcaga aucggccaga ccgccaccaa gcagaagacc      180

aacagccccg ccuggcacga cgaguucgug accgacgugu gcaacggcag aaagaucgag      240

cuggccgugu uccacgacgc ccccaucggc uacgacgacu ucguggccaa cugcaccauc      300

caguucgagg agcugcugca gaacggcagc agacacuucg aggacuggau cgaccuggag      360

cccgagggca gaguguacgu gaucaucgac cugagcggca gcagcggcga ggcccccaag      420

gacaacgagg agagaguguu cagagagaga augagaccca gaaagagaca gggcgccgug      480

agaagaagag ugcaccaggu gaacggccac aaguucaugg ccaccuaccu gagacagccc      540

accuacugca gccacugcag agacuucauc uggggcguga ucggcaagca gggcuaccag      600

ugccaggugu gcaccugcgu ggugcacaag agaugccacg agcugaucau caccaagugc      660

gccggccuga agaagcagga gacccccgac caggugggca gccagagauu cagcgugaac      720

augccccaca aguucggcau ccacaacuac aaggugccca ccuucugcga ccacugcggc      780

agccugcugu ggggccugcu gagacagggc cugcagugca aggugugcaa gaugaacgug      840

cacagaagau gcgagaccaa cguggccccc aacugcggcg uggacgccag aggcaucgcc      900

aaggugcugg ccgaccuggg cgugaccccc gacaagauca ccaacagcgg ccagagaaga      960

aagaagcuga ucgccggcgc cgagagcccc cagcccgcca gcggcagcag ccccagcgag     1020

gaggacagaa gcaagagcgc ccccaccagc cccugcgacc aggagaucaa ggagcuggag     1080

aacaacauca gaaaggcccu gagcuucgac aacagaggcg aggagcacag agccgccagc     1140

agccccgacg gccagcugau gagccccggc gagaacggcg aggugagaca gggccaggcc     1200

aagagacugg gccuggacga guucaacuuc aucaaggugc ugggcaaggg cagcuucggc     1260

aaggugaugc uggccgagcu gaagggcaag gacgaggugu acgccgugaa ggugcugaag     1320

aaggacguga uccugcagga cgacgacgug gacugcacca ugaccgagaa gagaauccug     1380

gcccuggcca gaaagcaccc cuaccugacc cagcuguacu gcugcuucca gaccaaggac     1440

agacuguucu ucgugaugga guacgugaac ggcggcgacc ugauguucca gauccagaga     1500

agcagaaagu ucgacgagcc cagaagcaga uucuacgccg ccgaggugac cagcgcccug     1560

auguuccugc accagcacgg cgugaucuac agagaccuga agcuggacaa cauccugcug     1620

gacgccgagg gccacugcaa gcuggccgac uucggcaugu gcaaggaggg cauccugaac     1680

ggcgugacca ccaccaccuu cugcggcacc cccgacuaca ucgcccccga gauccugcag     1740

gagcuggagu acggccccag cguggacugg ugggcccugg gcgugcugau guacgagaug     1800

auggccggcc agccccccuu cgaggccgac aacgaggacg accuguucga gagcauccug     1860

cacgacgacg ugcuguaccc cguguggcug agcaaggagg ccgugagcau ccugaaggcc     1920

uucaugacca agaaccccca caagagacug ggcugcgugg ccagccagaa cggcgaggac     1980

gccaucaagc agcaccccuu cuucaaggag aucgacuggg ugcugcugga gcagaagaag     2040

aucaagcccc ccuucaagcc cagaaucaag accaagagag acgugaacaa cuucgaccag     2100

gacuucacca gagaggagcc cgugcugacc cugguggacg aggccaucgu gaagcagauc     2160

aaccaggagg aguucaaggg cuucagcuac uucggcgagg accugaugcc cuga           2214


<210>  8884
<211>  2214
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCE__Homo_sapiens__AAI09034

<400>  8884
augguggucu ucaacggccu gcucaagauc aaaauuugcg aggccguuag ccugaagccc       60

accgcuuggu cccuuagaca cgccgugggg ccucggccgc agacauuucu gcucgacccc      120

uacaucgcgc ugaaugugga ugacucucgc auuggacaaa cggcuaccaa acagaagaca      180

aacagcccug ccuggcauga ugaguucguc accgacgugu guaauggcag aaaaaucgag      240

cuugccguuu uucacgaugc ucccauuggg uaugacgauu ucguggccaa cugcacaauc      300

caguuugaag aacugcucca gaauggaucc cggcauuucg aagacuggau cgaucuggag      360

ccugagggcc gcgucuacgu gauuaucgac cugucuggga gcuccggaga agcucccaag      420

gauaacgagg aaagaguuuu ucgggagcgc augagaccuc ggaagcgcca aggcgccgug      480

agacggcgcg uccaccaggu gaauggccau aaauucaugg cgaccuaucu cagacagccg      540

acauacuguu cucacugccg ggacuuuauu uggggaguga ucgggaagca gggcuaucaa      600

ugucaggucu gcaccugugu ugugcacaaa cgcugccaug agcugauuau cacgaagugu      660

gccgggcuua aaaagcagga aacccccgau caggugggaa gccaaagauu cuccgucaac      720

augccucaca aguuuggcau ucauaauuac aaagugccca cauucugcga ccacuguggg      780

agccugcucu ggggacugcu ucggcagggc cugcagugca agguuugcaa aaugaacgug      840

cacagacgcu gugagaccaa ugucgcuccu aacugcggcg uggacgcccg ggggaucgcu      900

aagguucucg ccgaucuggg agugacaccc gacaaaauca ccaauucugg ccaaagacgc      960

aagaaacuga uugcgggggc cgaauccccg cagccugcua gcggaucuuc ccccagcgag     1020

gaagaucggu cuaaguccgc cccuacgagc cccugugacc aggagaucaa ggagcucgaa     1080

aacaauauua gaaaagcucu guccuuugau aaccgcggcg aggaacaucg ggccgccucu     1140

agccccgacg ggcagcuuau guccccugga gagaacggcg aagucagaca aggccaggcu     1200

aagcgccugg ggcucgauga guucaauuuc aucaaagugc ugggaaaggg cagcuuuggg     1260

aaagucaugc uugcggagcu gaagggaaag gacgaagugu augccguuaa agugcucaag     1320

aaagauguca uucugcagga cgaugacgug gacugcacaa ugaccgagaa gcggauccug     1380

gcucucgcca gaaaacaccc guaccugaca cagcuuuacu guugcuucca aaccaaggau     1440

cgccuguuuu ucguuaugga auaugugaac ggcggggacc ucauguuuca gauccagcgg     1500

ucuagaaagu ucgaugagcc ccggucccgc uuuuacgccg cugaagucac cagcgcccug     1560

auguuccuuc aucagcacgg cgugauuuau agagaccuga aacucgauaa uauccugcug     1620

gacgcggagg gacauuguaa gcucgcugau uuuggcaugu gcaaagaggg gauucugaac     1680

ggagugacaa cgaccacauu cuguggcacc ccugacuaca ucgcccccga aauucuucaa     1740

gagcuggaau augggccuuc uguugauugg ugggcccucg gaguccugau guacgagaug     1800

auggcuggcc agcccccguu ugaggccgac aaugaagaug accuguucga gagcauccuu     1860

cacgaugacg ugcucuaucc uguguggcug uccaaggaag cugucucuau ccugaaagcc     1920

uuuaugacaa agaaccccca caagcggcuc gggugcgugg cgagccagaa uggcgaggac     1980

gccauuaaac agcauccuuu cuucaaggaa aucgauuggg uucugcuuga gcagaaaaag     2040

auuaaacccc cuuuuaagcc cagaaucaaa accaagcgcg acgugaacaa uuucgaucaa     2100

gacuuuacgc gggaggaacc gguccugaca cucguggaug aggcuauugu uaagcagauc     2160

aaccaagaag aguucaaagg auuuuccuac uucggcgaag accugaugcc uuga           2214


<210>  8885
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCG__Homo_sapiens__P05129

<400>  8885

Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg 
1               5                   10                  15      


Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
            20                  25                  30          


Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
        35                  40                  45              


Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
    50                  55                  60                  


Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
65                  70                  75                  80  


Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                85                  90                  95      


Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
            100                 105                 110         


Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
        115                 120                 125             


Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
    130                 135                 140                 


Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
145                 150                 155                 160 


Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr 
                165                 170                 175     


Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
        195                 200                 205             


Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
    210                 215                 220                 


Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
    290                 295                 300                 


Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
305                 310                 315                 320 


Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg 
                325                 330                 335     


Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
            340                 345                 350         


Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
        355                 360                 365             


Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
    370                 375                 380                 


Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
385                 390                 395                 400 


Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                405                 410                 415     


Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
            420                 425                 430         


Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
        435                 440                 445             


Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
    450                 455                 460                 


Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
465                 470                 475                 480 


Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                485                 490                 495     


Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr 
            500                 505                 510         


Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
        515                 520                 525             


Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
    530                 535                 540                 


Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
545                 550                 555                 560 


Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                565                 570                 575     


Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
            580                 585                 590         


His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
        595                 600                 605             


Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
    610                 615                 620                 


Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
625                 630                 635                 640 


Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                645                 650                 655     


Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
            660                 665                 670         


Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
        675                 680                 685             


Thr Ser Pro Val Pro Val Pro Val Met 
    690                 695         


<210>  8886
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCG__Homo_sapiens__AAH47876

<400>  8886
auggcugguc ugggccccgg cguaggcgau ucagaggggg gaccccggcc ccuguuuugc       60

agaaaggggg cccugaggca gaaggugguc cacgaaguca agagccacaa guucaccgcu      120

cgcuucuuca agcagcccac cuucugcagc cacugcaccg acuucaucug ggguaucgga      180

aagcagggcc ugcaauguca agucugcagc uuugugguuc aucgacgaug ccacgaauuu      240

gugaccuucg aguguccagg cgcugggaag ggcccccaga cggaugaccc ccggaacaaa      300

cacaaguucc gccugcauag cuacagcagc cccaccuucu gcgaccacug uggcucccuc      360

cucuacgggc uugugcacca gggcaugaaa ugcuccugcu gcgagaugaa cgugcaccgg      420

cgcugugugc guagcgugcc cucccugugc gguguggacc acaccgagcg ccgcgggcgc      480

cugcagcugg agauccgggc ucccacagca gaugagaucc acguaacugu uggcgaggcc      540

cguaaccuaa uuccuaugga ccccaauggu cucucugauc ccuaugugaa acugaagcuc      600

aucccagacc cucggaaccu gacgaaacag aagacccgaa cggugaaagc cacgcuaaac      660

ccugugugga augagaccuu uguguucaac cugaagccag gggaugugga gcgccggcuc      720

agcguggagg ugugggacug ggaccggacc ucccgcaacg acuucauggg ggccaugucc      780

uuuggcgucu cggagcugcu caaggcgccc guggauggcu gguacaaguu acugaaccag      840

gaggagggcg aguauuacaa ugugccggug gccgaugcug acaacugcag ccuccuccag      900

aaguuugagg cuuguaacua cccccuggaa uuguaugagc gggugcggau gggccccucu      960

uccucuccca uccccucccc uuccccuagu cccaccgacc ccaagcgcug cuucuucggg     1020

gcgaguccag gacgccugca caucuccgac uucagcuucc ucaugguucu aggaaaaggc     1080

aguuuuggga aggugaugcu ggccgagcgc aggggcucug augagcucua cgccaucaag     1140

aucuugaaaa aggacgugau cguccaggac gacgaugugg acugcacgcu gguggagaaa     1200

cgugugcugg cgcugggggg ccgggguccu ggcggccggc cccacuuccu cacccagcuc     1260

cacuccaccu uccagacccc ggaccgccug uauuucguga uggaguacgu caccggggga     1320

gacuugaugu accacauuca acagcugggc aaguuuaagg agccccaugc agcguucuac     1380

gcggcagaaa ucgcuaucgg ccucuucuuc cuucacaauc agggcaucau cuacagggac     1440

cugaagcugg acaaugugau gcuggaugcu gagggacaca ucaagaucac ugacuuuggc     1500

auguguaagg agaacgucuu ccccgggacg acaacccgca ccuucugcgg gaccccggac     1560

uacauagccc cggagaucau ugccuaccag cccuauggga agucugucga uugguggucc     1620

uuuggaguuc ugcuguauga gauguuggca ggacagccuc ccuucgaugg ggaggacgag     1680

gaggagcugu uucaggccau cauggaacaa acugucaccu accccaaguc gcuuucccgg     1740

gaagccgugg ccaucugcaa gggguuccug accaagcacc cagggaagcg ccugggcuca     1800

gggccugaug gggaaccuac cauccgugca cauggcuuuu uccgcuggau ugacugggag     1860

cggcuggaac gauuggagau cccgccuccu uucagacccc gcccgugugg ccgcagcggc     1920

gagaacuuug acaaguucuu cacgcgggcg gcgccagcgc ugaccccucc agaccgccua     1980

guccuggcca gcaucgacca ggccgauuuc cagggcuuca ccuacgugaa ccccgacuuc     2040

gugcacccgg augcccgcag ccccaccagc ccagugccug ugcccgucau guaa           2094


<210>  8887
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCG__Homo_sapiens__AAH47876

<400>  8887
auggccggcc uggggcccgg cgugggggac agcgagggcg ggccgcgccc ccucuucugc       60

cggaagggcg cccugcgcca gaaggucgug cacgagguga agucccacaa guucaccgcg      120

cgguucuuca agcagcccac cuucugcagc cacugcacgg acuucaucug gggcaucggg      180

aagcagggcc ugcagugcca ggucugcucc uucguggugc accgccggug ccacgaguuc      240

gucaccuucg agugccccgg ggccggcaag gggccgcaga ccgacgaccc ccgcaacaag      300

cacaaguucc ggcuccacag cuacuccagc cccaccuucu gcgaccacug cggcucccug      360

cuguacggcc ucgugcacca ggggaugaag ugcagcugcu gcgagaugaa cgugcaccgc      420

cggugcgucc gcuccgugcc cagccugugc ggcguggacc acacggagcg gcgcgggcgg      480

cugcagcucg agauccgcgc cccgaccgcc gacgagaucc acgucaccgu gggcgaggcc      540

cggaaccuga uccccaugga ccccaacggc cuguccgacc ccuacgugaa gcucaagcug      600

aucccggacc cccgcaaccu gaccaagcag aagacgcgga ccgucaaggc gacccucaac      660

cccgugugga acgagaccuu cguguucaac cugaagcccg gggacgucga gcgccggcug      720

agcguggagg ugugggacug ggaccgcacg ucccggaacg acuucauggg cgccaugagc      780

uucggggucu ccgagcuccu gaaggccccg guggacggcu gguacaagcu gcucaaccag      840

gaggaggggg aguacuacaa cgugcccguc gccgacgcgg acaacugcag ccugcugcag      900

aaguucgagg ccugcaacua cccccucgag cuguacgagc gcgugcgcau gggccccucc      960

agcuccccga uccccagccc cagccccucc ccgaccgacc ccaagcggug cuucuucggc     1020

gccagccccg ggcgccugca caucuccgac uucagcuucc ucaugguccu gggcaagggg     1080

uccuucggca aggugaugcu ggccgagcgg cgcgggagcg acgagcucua cgccaucaag     1140

auccugaaga aggacgugau cguccaggac gacgacgugg acugcacccu gguggagaag     1200

cggguccucg cgcugggcgg ccgcgggccc ggcgggcggc cgcacuuccu gacccagcuc     1260

cacuccacgu uccagacccc cgaccgccug uacuucguga uggaguacgu gaccggcggg     1320

gaccugaugu accacaucca gcagcucggc aaguucaagg agccccacgc cgccuucuac     1380

gccgccgaga ucgcgaucgg ccuguucuuc cugcacaacc aggggaucau cuaccgggac     1440

cucaagcugg acaacgucau gcuggacgcc gagggccaca ucaagaucac cgacuucggg     1500

augugcaagg agaacguguu cccgggcacg accacccgca ccuucugcgg cacgcccgac     1560

uacaucgccc ccgagaucau cgccuaccag cccuacggca agagcgugga cugguggucc     1620

uucggggucc uccuguacga gaugcuggcc gggcagccgc ccuucgacgg cgaggacgag     1680

gaggagcugu uccaggcgau cauggagcag accgugaccu accccaagag ccucucccgg     1740

gaggccgugg ccaucugcaa gggguuccug accaagcacc ccggcaagcg ccugggcagc     1800

gggccggacg gcgagcccac gauccgggcc cacggguucu uccgcuggau cgacugggag     1860

cggcucgagc gccuggagau cccgccgccc uuccggcccc gccccugcgg ccgguccggg     1920

gagaacuucg acaaguucuu cacccgcgcc gcgcccgccc ugaccccgcc cgaccgccuc     1980

guccuggcca gcaucgacca ggccgacuuc cagggcuuca ccuacgugaa ccccgacuuc     2040

gugcaccccg acgcgcgguc ccccacgagc cccguccccg ugcccgugau guga           2094


<210>  8888
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCG__Homo_sapiens__AAH47876

<400>  8888
auggccggcc ucggccccgg cgucggcgac uccgagggcg gcccccgccc ccucuucugc       60

cgcaagggcg cccuccgcca gaaggucguc cacgagguca agucccacaa guucaccgcc      120

cgcuucuuca agcagcccac cuucugcucc cacugcaccg acuucaucug gggcaucggc      180

aagcagggcc uccagugcca ggucugcucc uucgucgucc accgccgcug ccacgaguuc      240

gucaccuucg agugccccgg cgccggcaag ggcccccaga ccgacgaccc ccgcaacaag      300

cacaaguucc gccuccacuc cuacuccucc cccaccuucu gcgaccacug cggcucccuc      360

cucuacggcc ucguccacca gggcaugaag ugcuccugcu gcgagaugaa cguccaccgc      420

cgcugcgucc gcuccguccc cucccucugc ggcgucgacc acaccgagcg ccgcggccgc      480

cuccagcucg agauccgcgc ccccaccgcc gacgagaucc acgucaccgu cggcgaggcc      540

cgcaaccuca uccccaugga ccccaacggc cucuccgacc ccuacgucaa gcucaagcuc      600

auccccgacc cccgcaaccu caccaagcag aagacccgca ccgucaaggc cacccucaac      660

cccgucugga acgagaccuu cgucuucaac cucaagcccg gcgacgucga gcgccgccuc      720

uccgucgagg ucugggacug ggaccgcacc ucccgcaacg acuucauggg cgccaugucc      780

uucggcgucu ccgagcuccu caaggccccc gucgacggcu gguacaagcu ccucaaccag      840

gaggagggcg aguacuacaa cguccccguc gccgacgccg acaacugcuc ccuccuccag      900

aaguucgagg ccugcaacua cccccucgag cucuacgagc gcguccgcau gggccccucc      960

uccuccccca uccccucccc cucccccucc cccaccgacc ccaagcgcug cuucuucggc     1020

gccucccccg gccgccucca caucuccgac uucuccuucc ucaugguccu cggcaagggc     1080

uccuucggca aggucaugcu cgccgagcgc cgcggcuccg acgagcucua cgccaucaag     1140

auccucaaga aggacgucau cguccaggac gacgacgucg acugcacccu cgucgagaag     1200

cgcguccucg cccucggcgg ccgcggcccc ggcggccgcc cccacuuccu cacccagcuc     1260

cacuccaccu uccagacccc cgaccgccuc uacuucguca uggaguacgu caccggcggc     1320

gaccucaugu accacaucca gcagcucggc aaguucaagg agccccacgc cgccuucuac     1380

gccgccgaga ucgccaucgg ccucuucuuc cuccacaacc agggcaucau cuaccgcgac     1440

cucaagcucg acaacgucau gcucgacgcc gagggccaca ucaagaucac cgacuucggc     1500

augugcaagg agaacgucuu ccccggcacc accacccgca ccuucugcgg cacccccgac     1560

uacaucgccc ccgagaucau cgccuaccag cccuacggca aguccgucga cugguggucc     1620

uucggcgucc uccucuacga gaugcucgcc ggccagcccc ccuucgacgg cgaggacgag     1680

gaggagcucu uccaggccau cauggagcag accgucaccu accccaaguc ccucucccgc     1740

gaggccgucg ccaucugcaa gggcuuccuc accaagcacc ccggcaagcg ccucggcucc     1800

ggccccgacg gcgagcccac cauccgcgcc cacggcuucu uccgcuggau cgacugggag     1860

cgccucgagc gccucgagau cccccccccc uuccgccccc gccccugcgg ccgcuccggc     1920

gagaacuucg acaaguucuu cacccgcgcc gcccccgccc ucaccccccc cgaccgccuc     1980

guccucgccu ccaucgacca ggccgacuuc cagggcuuca ccuacgucaa ccccgacuuc     2040

guccaccccg acgcccgcuc ccccaccucc cccguccccg uccccgucau guga           2094


<210>  8889
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCG__Homo_sapiens__AAH47876

<400>  8889
auggccggcc uggggcccgg agugggugac agcgagggcg ggccuagacc acucuucugc       60

aggaagggag cucuacggca gaaagucguu cacgaaguga agucccauaa auuuacugca      120

cgcuucuuua agcaaccgac auucuguucu cacugcacug auuuuaucug gggcauuggu      180

aaacaggggc ugcaguguca gguaugcuca uucguggucc aucgacguug ucacgaguuu      240

gugacguucg aaugccccgg agccggcaag ggcccucaaa ccgacgaucc aagaaacaag      300

cauaaauuua gguugcacag uuacagcucc cccacauucu gugaccacug cgggucuuua      360

cuguauggac uuguucauca ggguaugaag uguucgugcu gugagaugaa ugugcaccgg      420

cgcugcguca gaucagugcc uagccucugc ggcguagauc auacugaaag gcgggggcgc      480

cugcagcuug agauacgagc gccaaccgcu gacgagaucc acguuacagu gggagaagcc      540

agaaaccuga uucccaugga uccuaauggc uugagugacc cauacgucaa acucaagcug      600

aucccggauc ccaggaaccu gaccaaacag aagacucgga cagugaaggc aacccucaau      660

ccugugugga acgagacguu ugucuucaau uuaaaaccag gugacguuga acgucgccug      720

uccguggagg uaugggauug ggacagaacu ucuaggaacg auuuuauggg ggccaugagc      780

uucggagugu ccgagcuuuu gaaggcuccc gucgacggcu gguauaaacu gcuaaaucaa      840

gaagagggcg aauacuauaa cgugccuguu gcagacgccg auaauuguuc acuccugcag      900

aaguucgagg cuugcaacua cccacuugaa cuguaugagc gggugcgaau ggggcccagu      960

agcucuccga uuccuucccc cucaccaagc ccuaccgacc ccaaacgcug cuuuuucgga     1020

gccaguccag guagauugca caucucugau uuuuccuucc ucaugguccu gggcaagggg     1080

agcuuuggaa aagugauguu agcggagagg cggggcucgg acgaacugua cgcaauaaag     1140

auccucaaga aagauguaau uguucaggac gaugacgugg auuguacacu ugucgagaag     1200

cgcgugcugg ccuugggugg gagaggcccc ggaggcaggc cucauuuccu aacucagcug     1260

cacucuaccu uucaaacacc agaccgucuc uacuucguca uggaauaugu gaccggggga     1320

gaucugaugu accauaucca gcagcuuggu aaauuuaagg agccgcacgc ugccuucuau     1380

gcagcugaaa uugccaucgg ccuguuuuuc uugcauaauc aagggauaau uuaccgggac     1440

cucaaacugg acaacguuau guuagaugcg gagggacaca ucaagauuac ggacuuuggc     1500

auguguaagg agaauguguu ccccgguacu acaacccgaa cuuucugcgg gacaccugau     1560

uauaucgccc cagaaaucau ugcauaccag cccuauggca aauccguaga cuggugguca     1620

uuuggagucc ugcuauacga gaugcucgcu ggccagccuc cauucgaugg ggaagacgag     1680

gaggaacugu uucaggccau aauggagcaa accgugacgu accccaagag ucuuagcaga     1740

gaagcuguug ccaucuguaa aggauucuug accaagcacc cggguaaaag gcugggcucc     1800

gggccugaug gagagccaac aauucgcgca cauggcuuuu uccgguggau cgacugggaa     1860

agacucgaga ggcuggagau acccccuccc uuucgcccac gaccuugcgg ucggucuggg     1920

gaaaacuucg auaaguuuuu cacucgugcc gcucccgcgc uuaccccacc ggacagacug     1980

guguuggcaa gcauugauca ggccgacuuu cagggcuuca cauaugucaa cccugauuuu     2040

gugcaccccg acgcuagguc accaaccagu cccguaccug ugccaguuau guga           2094


<210>  8890
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCG__Homo_sapiens__AAH47876

<400>  8890
auggccggcc ugggccccgg cgugggcgac agcgagggcg gccccagacc ccuguucugc       60

agaaagggcg cccugagaca gaagguggug cacgagguga agagccacaa guucaccgcc      120

agauucuuca agcagcccac cuucugcagc cacugcaccg acuucaucug gggcaucggc      180

aagcagggcc ugcagugcca ggugugcagc uucguggugc acagaagaug ccacgaguuc      240

gugaccuucg agugccccgg cgccggcaag ggcccccaga ccgacgaccc cagaaacaag      300

cacaaguuca gacugcacag cuacagcagc cccaccuucu gcgaccacug cggcagccug      360

cuguacggcc uggugcacca gggcaugaag ugcagcugcu gcgagaugaa cgugcacaga      420

agaugcguga gaagcgugcc cagccugugc ggcguggacc acaccgagag aagaggcaga      480

cugcagcugg agaucagagc ccccaccgcc gacgagaucc acgugaccgu gggcgaggcc      540

agaaaccuga uccccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcug      600

auccccgacc ccagaaaccu gaccaagcag aagaccagaa ccgugaaggc cacccugaac      660

cccgugugga acgagaccuu cguguucaac cugaagcccg gcgacgugga gagaagacug      720

agcguggagg ugugggacug ggacagaacc agcagaaacg acuucauggg cgccaugagc      780

uucggcguga gcgagcugcu gaaggccccc guggacggcu gguacaagcu gcugaaccag      840

gaggagggcg aguacuacaa cgugcccgug gccgacgccg acaacugcag ccugcugcag      900

aaguucgagg ccugcaacua cccccuggag cuguacgaga gagugagaau gggccccagc      960

agcagcccca uccccagccc cagccccagc cccaccgacc ccaagagaug cuucuucggc     1020

gccagccccg gcagacugca caucagcgac uucagcuucc ugauggugcu gggcaagggc     1080

agcuucggca aggugaugcu ggccgagaga agaggcagcg acgagcugua cgccaucaag     1140

auccugaaga aggacgugau cgugcaggac gacgacgugg acugcacccu gguggagaag     1200

agagugcugg cccugggcgg cagaggcccc ggcggcagac cccacuuccu gacccagcug     1260

cacagcaccu uccagacccc cgacagacug uacuucguga uggaguacgu gaccggcggc     1320

gaccugaugu accacaucca gcagcugggc aaguucaagg agccccacgc cgccuucuac     1380

gccgccgaga ucgccaucgg ccuguucuuc cugcacaacc agggcaucau cuacagagac     1440

cugaagcugg acaacgugau gcuggacgcc gagggccaca ucaagaucac cgacuucggc     1500

augugcaagg agaacguguu ccccggcacc accaccagaa ccuucugcgg cacccccgac     1560

uacaucgccc ccgagaucau cgccuaccag cccuacggca agagcgugga cugguggagc     1620

uucggcgugc ugcuguacga gaugcuggcc ggccagcccc ccuucgacgg cgaggacgag     1680

gaggagcugu uccaggccau cauggagcag accgugaccu accccaagag ccugagcaga     1740

gaggccgugg ccaucugcaa gggcuuccug accaagcacc ccggcaagag acugggcagc     1800

ggccccgacg gcgagcccac caucagagcc cacggcuucu ucagauggau cgacugggag     1860

agacuggaga gacuggagau cccccccccc uucagaccca gacccugcgg cagaagcggc     1920

gagaacuucg acaaguucuu caccagagcc gcccccgccc ugaccccccc cgacagacug     1980

gugcuggcca gcaucgacca ggccgacuuc cagggcuuca ccuacgugaa ccccgacuuc     2040

gugcaccccg acgccagaag ccccaccagc cccgugcccg ugcccgugau guga           2094


<210>  8891
<211>  2094
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCG__Homo_sapiens__AAH47876

<400>  8891
auggccggcc uggggcccgg agugggcgac agcgaagggg gaccuagacc gcuuuucugc       60

cggaagggcg cucugcgcca gaaagucguu cacgaaguga agucccauaa auuuaccgcc      120

agauucuuua agcaacccac auucuguucu cacugcacgg auuuuaucug ggggauugga      180

aaacagggcc uucaguguca ggugugcagc uucgucgugc aucggcgcug ucacgaguuu      240

guuaccuucg aaugcccugg cgcggggaag ggaccccaaa cagacgaucc uagaaacaag      300

cauaaauuuc ggcugcacuc cuacucuagc cccaccuucu gugaccacug cggcucccuc      360

cuguaugggc uugugcauca gggaaugaag uguucuugcu gugagaugaa uguccaccgc      420

agaugcgugc ggagcguucc uucccugugc ggcguggauc auacagaacg cagagggcgg      480

cuccagcugg agauccgcgc uccgaccgcc gacgagauuc acgucacagu gggagaagcc      540

agaaaccuga uccccaugga uccuaauggc cucagcgacc ccuacgugaa acugaagcuc      600

auuccugauc cccggaaccu gaccaaacag aagacgcgca ccgucaaggc uacacucaau      660

ccgguuugga acgagaccuu uguguucaau cugaaaccug gcgacgugga aagacggcuu      720

ucugucgagg ugugggauug ggacagaaca ucccgcaacg auuuuauggg ggccaugagc      780

uucggaguuu cugagcugcu caaggcuccc guggacggcu gguauaaacu gcugaaucaa      840

gaagaggggg aauacuauaa cgucccugug gccgacgcgg auaauuguuc ccuccugcag      900

aaguucgagg ccugcaacua cccccuugaa cuguaugagc ggguuagaau gggacccucu      960

agcuccccua ucccgagccc cuccccuucu cccaccgacc cuaaacgcug cuuuuucggc     1020

gcuagccccg ggcggcucca caucuccgau uuuagcuucc ugauggugcu uggaaagggc     1080

ucuuuuggca aagucaugcu ggccgagaga cgcggguccg acgaacucua cgcuauuaag     1140

auccugaaga aagaugugau uguccaggac gaugacgugg auuguacgcu gguugagaag     1200

cgggugcucg cccugggagg cagagggccg ggaggccgcc cucauuuccu uacacagcug     1260

cacagcaccu uucaaacacc cgaccggcuc uacuucguca uggaauaugu gaccgggggc     1320

gaucugaugu accauaucca gcagcuugga aaauuuaagg agccucacgc ggccuucuau     1380

gcugccgaaa uugcuaucgg ccuguuuuuc cuccauaauc aagggauuau cuacagagac     1440

cugaaacugg acaacguuau gcucgaugcc gagggacaca ucaagauuac cgacuuuggc     1500

auguguaagg agaauguguu ccccgggaca acgacccgca cauucugcgg aaccccugau     1560

uauaucgccc ccgaaauuau cgcuuaccag ccguauggca aaucugucga cugguggagc     1620

uuuggggugc ugcuuuacga gaugcuggcg ggccagccuc ccuucgaugg agaagacgag     1680

gaggagcucu uucaggccau uauggagcaa acagugaccu accccaaguc ccugucucgg     1740

gaagcuguug ccaucuguaa aggcuuccug acgaagcacc cugggaaaag acuuggaagc     1800

ggcccggaug gggagcccac aauccgggcc cauggauuuu uccgcuggau ugacugggaa     1860

agacucgagc ggcuggagau cccucccccu uuuagacccc gcccuugcgg ccgguccggg     1920

gaaaacuucg auaaguuuuu caccagagcu gcccccgcgc ugaccccgcc ugaccgccuc     1980

guccuggcua gcauugauca ggccgacuuu cagggcuuca cauaugugaa ccccgauuuu     2040

gugcacccug acgccagauc ucccaccucc ccggucccug ugcccguuau guga           2094


<210>  8892
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCI__Homo_sapiens__P41743

<400>  8892

Met Pro Thr Gln Arg Asp Ser Ser Thr Met Ser His Thr Val Ala Gly 
1               5                   10                  15      


Gly Gly Ser Gly Asp His Ser His Gln Val Arg Val Lys Ala Tyr Tyr 
            20                  25                  30          


Arg Gly Asp Ile Met Ile Thr His Phe Glu Pro Ser Ile Ser Phe Glu 
        35                  40                  45              


Gly Leu Cys Asn Glu Val Arg Asp Met Cys Ser Phe Asp Asn Glu Gln 
    50                  55                  60                  


Leu Phe Thr Met Lys Trp Ile Asp Glu Glu Gly Asp Pro Cys Thr Val 
65                  70                  75                  80  


Ser Ser Gln Leu Glu Leu Glu Glu Ala Phe Arg Leu Tyr Glu Leu Asn 
                85                  90                  95      


Lys Asp Ser Glu Leu Leu Ile His Val Phe Pro Cys Val Pro Glu Arg 
            100                 105                 110         


Pro Gly Met Pro Cys Pro Gly Glu Asp Lys Ser Ile Tyr Arg Arg Gly 
        115                 120                 125             


Ala Arg Arg Trp Arg Lys Leu Tyr Cys Ala Asn Gly His Thr Phe Gln 
    130                 135                 140                 


Ala Lys Arg Phe Asn Arg Arg Ala His Cys Ala Ile Cys Thr Asp Arg 
145                 150                 155                 160 


Ile Trp Gly Leu Gly Arg Gln Gly Tyr Lys Cys Ile Asn Cys Lys Leu 
                165                 170                 175     


Leu Val His Lys Lys Cys His Lys Leu Val Thr Ile Glu Cys Gly Arg 
            180                 185                 190         


His Ser Leu Pro Gln Glu Pro Val Met Pro Met Asp Gln Ser Ser Met 
        195                 200                 205             


His Ser Asp His Ala Gln Thr Val Ile Pro Tyr Asn Pro Ser Ser His 
    210                 215                 220                 


Glu Ser Leu Asp Gln Val Gly Glu Glu Lys Glu Ala Met Asn Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Lys Ala Ser Ser Ser Leu Gly Leu Gln Asp Phe Asp Leu 
                245                 250                 255     


Leu Arg Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg 
            260                 265                 270         


Leu Lys Lys Thr Asp Arg Ile Tyr Ala Met Lys Val Val Lys Lys Glu 
        275                 280                 285             


Leu Val Asn Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His 
    290                 295                 300                 


Val Phe Glu Gln Ala Ser Asn His Pro Phe Leu Val Gly Leu His Ser 
305                 310                 315                 320 


Cys Phe Gln Thr Glu Ser Arg Leu Phe Phe Val Ile Glu Tyr Val Asn 
                325                 330                 335     


Gly Gly Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu 
            340                 345                 350         


Glu His Ala Arg Phe Tyr Ser Ala Glu Ile Ser Leu Ala Leu Asn Tyr 
        355                 360                 365             


Leu His Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val 
    370                 375                 380                 


Leu Leu Asp Ser Glu Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys 
385                 390                 395                 400 


Lys Glu Gly Leu Arg Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr 
                405                 410                 415     


Pro Asn Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Asp Tyr Gly Phe 
            420                 425                 430         


Ser Val Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala 
        435                 440                 445             


Gly Arg Ser Pro Phe Asp Ile Val Gly Ser Ser Asp Asn Pro Asp Gln 
    450                 455                 460                 


Asn Thr Glu Asp Tyr Leu Phe Gln Val Ile Leu Glu Lys Gln Ile Arg 
465                 470                 475                 480 


Ile Pro Arg Ser Leu Ser Val Lys Ala Ala Ser Val Leu Lys Ser Phe 
                485                 490                 495     


Leu Asn Lys Asp Pro Lys Glu Arg Leu Gly Cys His Pro Gln Thr Gly 
            500                 505                 510         


Phe Ala Asp Ile Gln Gly His Pro Phe Phe Arg Asn Val Asp Trp Asp 
        515                 520                 525             


Met Met Glu Gln Lys Gln Val Val Pro Pro Phe Lys Pro Asn Ile Ser 
    530                 535                 540                 


Gly Glu Phe Gly Leu Asp Asn Phe Asp Ser Gln Phe Thr Asn Glu Pro 
545                 550                 555                 560 


Val Gln Leu Thr Pro Asp Asp Asp Asp Ile Val Arg Lys Ile Asp Gln 
                565                 570                 575     


Ser Glu Phe Glu Gly Phe Glu Tyr Ile Asn Pro Leu Leu Met Ser Ala 
            580                 585                 590         


Glu Glu Cys Val 
        595     


<210>  8893
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCI__Homo_sapiens__EAW78513

<400>  8893
augccgaccc agagggacag cagcaccaug ucccacacgg ucgcaggcgg cggcagcggg       60

gaccauuccc accagguccg ggugaaagcc uacuaccgcg gggauaucau gauaacacau      120

uuugaaccuu ccaucuccuu ugagggccuu ugcaaugagg uucgagacau guguucuuuu      180

gacaacgaac agcucuucac caugaaaugg auagaugagg aaggagaccc guguacagua      240

ucaucucagu uggaguuaga agaagccuuu agacuuuaug agcuaaacaa ggauucugaa      300

cucuugauuc auguguuccc uuguguacca gaacguccug ggaugccuug uccaggagaa      360

gauaaaucca ucuaccguag aggugcacgc cgcuggagaa agcuuuauug ugccaauggc      420

cacacuuucc aagccaagcg uuucaacagg cgugcucacu gugccaucug cacagaccga      480

auauggggac uuggacgcca aggauauaag ugcaucaacu gcaaacucuu gguucauaag      540

aagugccaua aacucgucac aauugaaugu gggcggcauu cuuugccaca ggaaccagug      600

augcccaugg aucagucauc caugcauucu gaccaugcac agacaguaau uccauauaau      660

ccuucaaguc augagaguuu ggaucaaguu ggugaagaaa aagaggcaau gaacaccagg      720

gaaaguggca aagcuucauc cagucuaggu cuucaggauu uugauuugcu ccggguaaua      780

ggaagaggaa guuaugccaa aguacuguug guucgauuaa aaaaaacaga ucguauuuau      840

gcaaugaaag uugugaaaaa agagcuuguu aaugaugaug aggauauuga uuggguacag      900

acagagaagc auguguuuga gcaggcaucc aaucauccuu uccuuguugg gcugcauucu      960

ugcuuucaga cagaaagcag auuguucuuu guuauagagu auguaaaugg aggagaccua     1020

auguuucaua ugcagcgaca aagaaaacuu ccugaagaac augccagauu uuacucugca     1080

gaaaucaguc uagcauuaaa uuaucuucau gagcgaggga uaauuuauag agauuugaaa     1140

cuggacaaug uauuacugga cucugaaggc cacauuaaac ucacugacua cggcaugugu     1200

aaggaaggau uacggccagg agauacaacc agcacuuucu gugguacucc uaauuacauu     1260

gcuccugaaa uuuuaagagg agaagauuau gguuucagug uugacuggug ggcucuugga     1320

gugcucaugu uugagaugau ggcaggaagg ucuccauuug auauuguugg gagcuccgau     1380

aacccugacc agaacacaga ggauuaucuc uuccaaguua uuuuggaaaa acaaauucgc     1440

auaccacguu cucugucugu aaaagcugca aguguucuga agaguuuucu uaauaaggac     1500

ccuaaggaac gauuggguug ucauccucaa acaggauuug cugauauuca gggacacccg     1560

uucuuccgaa auguugauug ggauaugaug gagcaaaaac aggugguacc ucccuuuaaa     1620

ccaaauauuu cuggggaauu ugguuuggac aacuuugauu cucaguuuac uaaugaaccu     1680

guccagcuca cuccagauga cgaugacauu gugaggaaga uugaucaguc ugaauuugaa     1740

gguuuugagu auaucaaucc ucuuuugaug ucugcagaag aaugugucug a              1791


<210>  8894
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCI__Homo_sapiens__EAW78513

<400>  8894
augcccaccc agcgcgacag cuccaccaug agccacacgg uggccggcgg gggcuccggg       60

gaccacagcc accagguccg ggugaaggcc uacuaccgcg gcgacaucau gaucacccac      120

uucgagccgu ccaucagcuu cgaggggcug ugcaacgagg ugcgggacau gugcuccuuc      180

gacaacgagc agcuguucac caugaagugg aucgacgagg agggcgaccc cugcaccguc      240

agcucccagc ucgagcugga ggaggcguuc cgccucuacg agcugaacaa ggacagcgag      300

cugcucaucc acguguuccc cugcgugccc gagcggccgg gcaugcccug ccccggggag      360

gacaagucca ucuaccgccg gggcgcccgc cgguggcgca agcuguacug cgccaacggg      420

cacacguucc aggccaagcg guucaaccgc cgggcccacu gcgcgaucug caccgaccgc      480

aucuggggcc uggggcggca gggcuacaag ugcaucaacu gcaagcuccu gguccacaag      540

aagugccaca agcuggugac caucgagugc ggccgccaca gccuccccca ggagccggug      600

augcccaugg accaguccag caugcacucc gaccacgccc agaccgucau ccccuacaac      660

cccagcuccc acgagagccu ggaccaggug ggggaggaga aggaggccau gaacacgcgg      720

gaguccggca aggccagcag cucccugggg cuccaggacu ucgaccugcu gcgcgugauc      780

ggccggggca gcuacgcgaa gguccuccug gugcgccuga agaagaccga ccggaucuac      840

gccaugaagg uggucaagaa ggagcucgug aacgacgacg aggacaucga cugggugcag      900

accgagaagc acgucuucga gcaggccucc aaccacccgu uccugguggg gcugcacagc      960

ugcuuccaga ccgagucccg ccucuucuuc gugaucgagu acgucaacgg cggggaccug     1020

auguuccaca ugcagcgcca gcggaagcug cccgaggagc acgcccgcuu cuacagcgcc     1080

gagaucuccc ucgcgcugaa cuaccugcac gagcggggca ucaucuaccg cgaccucaag     1140

cuggacaacg ugcugcucga cagcgagggg cacaucaagc ugacggacua cggcaugugc     1200

aaggagggcc ugcggcccgg ggacaccacc uccaccuucu gcggcacgcc caacuacauc     1260

gccccggaga uccuccgcgg ggaggacuac ggcuucagcg uggacuggug ggcccugggg     1320

guccugaugu ucgagaugau ggccggccgg ucccccuucg acaucguggg cagcuccgac     1380

aaccccgacc agaacaccga ggacuaccuc uuccagguca uccuggagaa gcagauccgc     1440

aucccccgga gccuguccgu gaaggccgcg agcgugcuca aguccuuccu gaacaaggac     1500

ccgaaggagc gccuggggug ccacccccag accggcuucg ccgacaucca ggggcacccc     1560

uucuuccgga acgucgacug ggacaugaug gagcagaagc aggucgugcc cccguucaag     1620

cccaacauca gcggcgaguu cgggcucgac aacuucgacu cccaguucac caacgagccc     1680

gugcagcuga cgcccgacga cgacgacauc gugcgcaaga ucgaccagag cgaguucgag     1740

ggcuucgagu acaucaaccc gcugcucaug agcgccgagg agugcgugug a              1791


<210>  8895
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCI__Homo_sapiens__EAW78513

<400>  8895
augcccaccc agcgcgacuc cuccaccaug ucccacaccg ucgccggcgg cggcuccggc       60

gaccacuccc accagguccg cgucaaggcc uacuaccgcg gcgacaucau gaucacccac      120

uucgagcccu ccaucuccuu cgagggccuc ugcaacgagg uccgcgacau gugcuccuuc      180

gacaacgagc agcucuucac caugaagugg aucgacgagg agggcgaccc cugcaccguc      240

uccucccagc ucgagcucga ggaggccuuc cgccucuacg agcucaacaa ggacuccgag      300

cuccucaucc acgucuuccc cugcgucccc gagcgccccg gcaugcccug ccccggcgag      360

gacaagucca ucuaccgccg cggcgcccgc cgcuggcgca agcucuacug cgccaacggc      420

cacaccuucc aggccaagcg cuucaaccgc cgcgcccacu gcgccaucug caccgaccgc      480

aucuggggcc ucggccgcca gggcuacaag ugcaucaacu gcaagcuccu cguccacaag      540

aagugccaca agcucgucac caucgagugc ggccgccacu cccuccccca ggagcccguc      600

augcccaugg accaguccuc caugcacucc gaccacgccc agaccgucau ccccuacaac      660

cccuccuccc acgagucccu cgaccagguc ggcgaggaga aggaggccau gaacacccgc      720

gaguccggca aggccuccuc cucccucggc cuccaggacu ucgaccuccu ccgcgucauc      780

ggccgcggcu ccuacgccaa gguccuccuc guccgccuca agaagaccga ccgcaucuac      840

gccaugaagg ucgucaagaa ggagcucguc aacgacgacg aggacaucga cuggguccag      900

accgagaagc acgucuucga gcaggccucc aaccaccccu uccucgucgg ccuccacucc      960

ugcuuccaga ccgagucccg ccucuucuuc gucaucgagu acgucaacgg cggcgaccuc     1020

auguuccaca ugcagcgcca gcgcaagcuc cccgaggagc acgcccgcuu cuacuccgcc     1080

gagaucuccc ucgcccucaa cuaccuccac gagcgcggca ucaucuaccg cgaccucaag     1140

cucgacaacg uccuccucga cuccgagggc cacaucaagc ucaccgacua cggcaugugc     1200

aaggagggcc uccgccccgg cgacaccacc uccaccuucu gcggcacccc caacuacauc     1260

gcccccgaga uccuccgcgg cgaggacuac ggcuucuccg ucgacuggug ggcccucggc     1320

guccucaugu ucgagaugau ggccggccgc ucccccuucg acaucgucgg cuccuccgac     1380

aaccccgacc agaacaccga ggacuaccuc uuccagguca uccucgagaa gcagauccgc     1440

aucccccgcu cccucuccgu caaggccgcc uccguccuca aguccuuccu caacaaggac     1500

cccaaggagc gccucggcug ccacccccag accggcuucg ccgacaucca gggccacccc     1560

uucuuccgca acgucgacug ggacaugaug gagcagaagc aggucguccc ccccuucaag     1620

cccaacaucu ccggcgaguu cggccucgac aacuucgacu cccaguucac caacgagccc     1680

guccagcuca cccccgacga cgacgacauc guccgcaaga ucgaccaguc cgaguucgag     1740

ggcuucgagu acaucaaccc ccuccucaug uccgccgagg agugcgucug a              1791


<210>  8896
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCI__Homo_sapiens__EAW78513

<400>  8896
augcccaccc agagagacag cuccacaaug ucucacacug uggccggcgg gggaucaggu       60

gaucauaguc accaagucag gguuaaggcu uacuaucggg gcgacaucau gauuacgcau      120

uucgagccua gcauauccuu ugaagggcug ugcaacgagg ugcgcgauau guguucuuuc      180

gacaaugaac agcucuuuac caugaaaugg aucgaugagg aaggagaccc augcacagua      240

ucgucacagc uugagcugga ggaagcauuc cgauuguacg aguuaaacaa ggauagcgaa      300

cugcuaauuc acguguuucc gugugucccc gagcguccug gcaugccaug ccccggugag      360

gacaaaagua ucuauagaag gggagcccgg cgcuggagaa agcucuacug ugcgaauggg      420

cauacuuucc aggcuaaaag guuuaaccgg cgcgcccacu gcgcaauuug uaccgaucga      480

aucuggggcc ugggcagaca aggguauaag ugcauaaauu guaagcuacu ggugcacaaa      540

aagugccaua aauugguuac aaucgaaugu ggaaggcacu cccucccuca ggagccagug      600

augcccaugg accagucuag caugcauucc gaucacgccc agaccgucau uccuuacaac      660

ccaucaaguc acgaaagccu ggaccaagug ggugaggaaa aggaggcuau gaauacucgg      720

gagucuggca aagcauccuc aagccugggg cuccaggauu ucgacuuacu gcguguaauc      780

ggacgcggca guuaugccaa gguucuuuug gugagacuga agaaaacaga caggauuuac      840

gcuaugaagg ucgugaaaaa ggaacuugug aacgaugacg aggauaucga cuggguccag      900

accgaaaaac auguuuuuga gcaggccucu aaucacccgu uccucguggg ucugcauucc      960

ugcuuucaaa cggaaagccg gcuuuucuuu guaauagagu acgugaacgg gggagaucug     1020

auguuccaca ugcagcgaca gcgcaaguug cccgaggaac augcgagauu cuauucggca     1080

gagauuucuc ucgcccugaa uuacuuacac gaaaggggca ucauuuaucg ggaccugaaa     1140

cucgauaacg uccuucugga cuccgagggc cacaucaagu ugacugauua cgggaugugc     1200

aaggaaggac uacgcccugg ugacaccaca ucaacuuuuu guggcacccc aaauuauauc     1260

gcucccgaga uucugagagg ggaggauuac ggauucagug uggacuggug ggcccucggc     1320

guucugaugu uugaaaugau ggcagguagg agcccuuucg acauaguggg guccucugau     1380

aacccagacc aaaauacaga ggauuaucuu uuucagguca uccuggaaaa acagauucgu     1440

aucccccgga gcuugucagu gaaggcugcc aguguacuca aauccuuccu gaacaaggac     1500

ccgaaagagc gauuaggcug ccauccucag accggauuug cggauauaca aggccacccc     1560

uucuuuagaa acguugacug ggauaugaug gagcagaaac aggugguccc accuuucaag     1620

cccaauauua gcggggaauu uggacuggac aacuucgauu cucaguuuac gaaugagcca     1680

gugcaacuaa cucccgacga ugacgauauc gucaggaaga ucgaccaguc agaguucgaa     1740

gguuucgaau acauuaaccc ucuccugaug agugccgagg agugugugug a              1791


<210>  8897
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCI__Homo_sapiens__EAW78513

<400>  8897
augcccaccc agagagacag cagcaccaug agccacaccg uggccggcgg cggcagcggc       60

gaccacagcc accaggugag agugaaggcc uacuacagag gcgacaucau gaucacccac      120

uucgagccca gcaucagcuu cgagggccug ugcaacgagg ugagagacau gugcagcuuc      180

gacaacgagc agcuguucac caugaagugg aucgacgagg agggcgaccc cugcaccgug      240

agcagccagc uggagcugga ggaggccuuc agacuguacg agcugaacaa ggacagcgag      300

cugcugaucc acguguuccc cugcgugccc gagagacccg gcaugcccug ccccggcgag      360

gacaagagca ucuacagaag aggcgccaga agauggagaa agcuguacug cgccaacggc      420

cacaccuucc aggccaagag auucaacaga agagcccacu gcgccaucug caccgacaga      480

aucuggggcc ugggcagaca gggcuacaag ugcaucaacu gcaagcugcu ggugcacaag      540

aagugccaca agcuggugac caucgagugc ggcagacaca gccugcccca ggagcccgug      600

augcccaugg accagagcag caugcacagc gaccacgccc agaccgugau ccccuacaac      660

cccagcagcc acgagagccu ggaccaggug ggcgaggaga aggaggccau gaacaccaga      720

gagagcggca aggccagcag cagccugggc cugcaggacu ucgaccugcu gagagugauc      780

ggcagaggca gcuacgccaa ggugcugcug gugagacuga agaagaccga cagaaucuac      840

gccaugaagg uggugaagaa ggagcuggug aacgacgacg aggacaucga cugggugcag      900

accgagaagc acguguucga gcaggccagc aaccaccccu uccugguggg ccugcacagc      960

ugcuuccaga ccgagagcag acuguucuuc gugaucgagu acgugaacgg cggcgaccug     1020

auguuccaca ugcagagaca gagaaagcug cccgaggagc acgccagauu cuacagcgcc     1080

gagaucagcc uggcccugaa cuaccugcac gagagaggca ucaucuacag agaccugaag     1140

cuggacaacg ugcugcugga cagcgagggc cacaucaagc ugaccgacua cggcaugugc     1200

aaggagggcc ugagacccgg cgacaccacc agcaccuucu gcggcacccc caacuacauc     1260

gcccccgaga uccugagagg cgaggacuac ggcuucagcg uggacuggug ggcccugggc     1320

gugcugaugu ucgagaugau ggccggcaga agccccuucg acaucguggg cagcagcgac     1380

aaccccgacc agaacaccga ggacuaccug uuccagguga uccuggagaa gcagaucaga     1440

auccccagaa gccugagcgu gaaggccgcc agcgugcuga agagcuuccu gaacaaggac     1500

cccaaggaga gacugggcug ccacccccag accggcuucg ccgacaucca gggccacccc     1560

uucuucagaa acguggacug ggacaugaug gagcagaagc agguggugcc ccccuucaag     1620

cccaacauca gcggcgaguu cggccuggac aacuucgaca gccaguucac caacgagccc     1680

gugcagcuga cccccgacga cgacgacauc gugagaaaga ucgaccagag cgaguucgag     1740

ggcuucgagu acaucaaccc ccugcugaug agcgccgagg agugcgugug a              1791


<210>  8898
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCI__Homo_sapiens__EAW78513

<400>  8898
augcccaccc agagagacag cuccacaaug ucucacacgg uggccggcgg gggaagcggc       60

gaucauuccc accaaguccg gguuaaggcu uacuaucgcg gggacaucau gauuacccau      120

uucgagccuu cuaucagcuu ugaaggacug ugcaacgagg ugagagauau guguuccuuc      180

gacaaugaac agcucuuuac aaugaaaugg auugaugagg aaggcgaccc gugcaccgug      240

ucuagccagc uggagcuuga ggaagccuuc cggcuguacg agcucaacaa ggauuccgaa      300

cugcuuaucc acgucuuucc cugugugccu gagcgccccg ggaugccuug ccccggagag      360

gacaaaagca uuuauagacg gggcgcgcgc agauggcgga agcuguacug ugcuaauggc      420

cauacauucc aggccaaacg cuuuaacaga cgggcccacu gcgcuaucug uaccgaucgc      480

aucugggggc ucggaagaca aggcuauaag ugcauuaauu guaagcugcu gguucacaaa      540

aagugccaua aacucgugac aaucgaaugu gggcggcacu cucugccuca ggagccgguc      600

augcccaugg accaguccag caugcauucu gaucacgccc agaccgugau uccuuacaac      660

cccuccagcc acgaaucucu ugaccaaguu ggagaggaaa aggaggcuau gaauacgcgc      720

gaguccggca aagccagcuc cucucugggg cuccaggauu ucgaccugcu uagagugauc      780

ggacggggca gcuaugcgaa gguccugcuc gugagacuga agaaaaccga ccgcauuuac      840

gccaugaagg uggucaaaaa ggaacugguu aacgaugacg aggauaucga cugggugcag      900

acagaaaaac auguguuuga gcaggcuucc aaucacccuu uccucgucgg ccugcauagc      960

ugcuuucaaa ccgaaucucg gcuuuucuuu gugauugagu acguuaacgg gggagaucug     1020

auguuccaca ugcagagaca gcgcaagcuc cccgaggaac augcccgguu cuauuccgcu     1080

gagaucagcc uggcccuuaa uuaccugcac gaaagaggca ucauuuaucg cgaccucaaa     1140

cuggauaacg ugcugcucga cucugagggg cacaucaagc ugacagauua cggaaugugc     1200

aaggaaggcc uucggccggg ggacaccacg agcacauuuu guggaacccc uaauuauauu     1260

gcgcccgaga uccugagagg cgaggauuac ggcuucuccg ucgacuggug ggcccucggg     1320

gugcugaugu uugaaaugau ggcuggacgc ucuccuuucg acauuguugg cagcuccgau     1380

aaccccgacc aaaauacaga ggauuaucuu uuucagguga uccuggaaaa acagauccgg     1440

auucccagaa gccucucugu caaggccgcu uccgugcuga aaucuuuccu gaacaaggac     1500

ccuaaagagc gccucgggug ccauccgcag accggauuug ccgauaucca aggccacccc     1560

uucuuucgga acgucgacug ggauaugaug gagcagaaac aggugguucc ucccuucaag     1620

ccuaauauua gcggggaauu uggccuggac aacuucgauu cccaguuuac caaugagccc     1680

gugcaacuua caccggacga ugacgauauc gucagaaaga uugaccagag cgaguucgaa     1740

ggauucgaau acaucaaccc ucugcucaug uccgccgagg agugugugug a              1791


<210>  8899
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCL__Homo_sapiens__P24723

<400>  8899

Met Ser Ser Gly Thr Met Lys Phe Asn Gly Tyr Leu Arg Val Arg Ile 
1               5                   10                  15      


Gly Glu Ala Val Gly Leu Gln Pro Thr Arg Trp Ser Leu Arg His Ser 
            20                  25                  30          


Leu Phe Lys Lys Gly His Gln Leu Leu Asp Pro Tyr Leu Thr Val Ser 
        35                  40                  45              


Val Asp Gln Val Arg Val Gly Gln Thr Ser Thr Lys Gln Lys Thr Asn 
    50                  55                  60                  


Lys Pro Thr Tyr Asn Glu Glu Phe Cys Ala Asn Val Thr Asp Gly Gly 
65                  70                  75                  80  


His Leu Glu Leu Ala Val Phe His Glu Thr Pro Leu Gly Tyr Asp His 
                85                  90                  95      


Phe Val Ala Asn Cys Thr Leu Gln Phe Gln Glu Leu Leu Arg Thr Thr 
            100                 105                 110         


Gly Ala Ser Asp Thr Phe Glu Gly Trp Val Asp Leu Glu Pro Glu Gly 
        115                 120                 125             


Lys Val Phe Val Val Ile Thr Leu Thr Gly Ser Phe Thr Glu Ala Thr 
    130                 135                 140                 


Leu Gln Arg Asp Arg Ile Phe Lys His Phe Thr Arg Lys Arg Gln Arg 
145                 150                 155                 160 


Ala Met Arg Arg Arg Val His Gln Ile Asn Gly His Lys Phe Met Ala 
                165                 170                 175     


Thr Tyr Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Glu Phe Ile 
            180                 185                 190         


Trp Gly Val Phe Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys 
        195                 200                 205             


Val Val His Lys Arg Cys His His Leu Ile Val Thr Ala Cys Thr Cys 
    210                 215                 220                 


Gln Asn Asn Ile Asn Lys Val Asp Ser Lys Ile Ala Glu Gln Arg Phe 
225                 230                 235                 240 


Gly Ile Asn Ile Pro His Lys Phe Ser Ile His Asn Tyr Lys Val Pro 
                245                 250                 255     


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Ile Met Arg Gln 
            260                 265                 270         


Gly Leu Gln Cys Lys Ile Cys Lys Met Asn Val His Ile Arg Cys Gln 
        275                 280                 285             


Ala Asn Val Ala Pro Asn Cys Gly Val Asn Ala Val Glu Leu Ala Lys 
    290                 295                 300                 


Thr Leu Ala Gly Met Gly Leu Gln Pro Gly Asn Ile Ser Pro Thr Ser 
305                 310                 315                 320 


Lys Leu Val Ser Arg Ser Thr Leu Arg Arg Gln Gly Lys Glu Ser Ser 
                325                 330                 335     


Lys Glu Gly Asn Gly Ile Gly Val Asn Ser Ser Asn Arg Leu Gly Ile 
            340                 345                 350         


Asp Asn Phe Glu Phe Ile Arg Val Leu Gly Lys Gly Ser Phe Gly Lys 
        355                 360                 365             


Val Met Leu Ala Arg Val Lys Glu Thr Gly Asp Leu Tyr Ala Val Lys 
    370                 375                 380                 


Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp Asp Val Glu Cys Thr 
385                 390                 395                 400 


Met Thr Glu Lys Arg Ile Leu Ser Leu Ala Arg Asn His Pro Phe Leu 
                405                 410                 415     


Thr Gln Leu Phe Cys Cys Phe Gln Thr Pro Asp Arg Leu Phe Phe Val 
            420                 425                 430         


Met Glu Phe Val Asn Gly Gly Asp Leu Met Phe His Ile Gln Lys Ser 
        435                 440                 445             


Arg Arg Phe Asp Glu Ala Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ile 
    450                 455                 460                 


Ser Ala Leu Met Phe Leu His Asp Lys Gly Ile Ile Tyr Arg Asp Leu 
465                 470                 475                 480 


Lys Leu Asp Asn Val Leu Leu Asp His Glu Gly His Cys Lys Leu Ala 
                485                 490                 495     


Asp Phe Gly Met Cys Lys Glu Gly Ile Cys Asn Gly Val Thr Thr Ala 
            500                 505                 510         


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Leu Gln Glu 
        515                 520                 525             


Met Leu Tyr Gly Pro Ala Val Asp Trp Trp Ala Met Gly Val Leu Leu 
    530                 535                 540                 


Tyr Glu Met Leu Cys Gly His Ala Pro Phe Glu Ala Glu Asn Glu Asp 
545                 550                 555                 560 


Asp Leu Phe Glu Ala Ile Leu Asn Asp Glu Val Val Tyr Pro Thr Trp 
                565                 570                 575     


Leu His Glu Asp Ala Thr Gly Ile Leu Lys Ser Phe Met Thr Lys Asn 
            580                 585                 590         


Pro Thr Met Arg Leu Gly Ser Leu Thr Gln Gly Gly Glu His Ala Ile 
        595                 600                 605             


Leu Arg His Pro Phe Phe Lys Glu Ile Asp Trp Ala Gln Leu Asn His 
    610                 615                 620                 


Arg Gln Ile Glu Pro Pro Phe Arg Pro Arg Ile Lys Ser Arg Glu Asp 
625                 630                 635                 640 


Val Ser Asn Phe Asp Pro Asp Phe Ile Lys Glu Glu Pro Val Leu Thr 
                645                 650                 655     


Pro Ile Asp Glu Gly His Leu Pro Met Ile Asn Gln Asp Glu Phe Arg 
            660                 665                 670         


Asn Phe Ser Tyr Val Ser Pro Glu Leu Gln Pro 
        675                 680             


<210>  8900
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCL__Homo_sapiens__AAH37268

<400>  8900
augucgucug gcaccaugaa guucaauggc uauuugaggg uccgcaucgg ugaggcagug       60

gggcugcagc ccacccgcug gucccugcgc cacucgcucu ucaagaaggg ccaccagcug      120

cuggaccccu aucugacggu gagcguggac caggugcgcg ugggccagac cagcaccaag      180

cagaagacca acaaacccac guacaacgag gaguuuugcg cuaacgucac cgacggcggc      240

caccucgagu uggccgucuu ccacgagacg ccccugggcu acgaccacuu cguggccaac      300

ugcacccugc aguuccagga gcugcugcgc acgaccggcg ccucggacac cuucgagggu      360

uggguggauc ucgagccaga ggggaaagua uucgugguaa uaacccuuac cgggaguuuc      420

acugaagcua cucuccagag agaccggauc uucaaacauu uuaccaggaa gcgccaaagg      480

gcuaugcgaa ggcgagucca ccagaucaau ggacacaagu ucauggccac guaucugagg      540

cagcccaccu acugcucuca cugcagggag uuuaucuggg gaguguuugg gaaacagggu      600

uaucagugcc aagugugcac cugugucguc cauaaacgcu gccaucaucu aauuguuaca      660

gccuguacuu gccaaaacaa uauuaacaaa guggauucaa agauugcaga acagagguuc      720

gggaucaaca ucccacacaa guucagcauc cacaacuaca aagugccaac auucugcgau      780

cacuguggcu cacugcucug gggaauaaug cgacaaggac uucaguguaa aauauguaaa      840

augaaugugc auauucgaug ucaagcgaac guggccccua acuguggggu aaaugcggug      900

gaacuugcca agacccuggc agggaugggu cuccaacccg gaaauauuuc uccaaccucg      960

aaacucguuu ccagaucgac ccuaagacga cagggaaagg agagcagcaa agaaggaaau     1020

gggauugggg uuaauucuuc caaccgacuu gguaucgaca acuuugaguu cauccgagug     1080

uuggggaagg ggaguuuugg gaaggugaug cuugcaagag uaaaagaaac aggagaccuc     1140

uaugcuguga aggugcugaa gaaggacgug auucugcagg augaugaugu ggaaugcacc     1200

augaccgaga aaaggauccu gucucuggcc cgcaaucacc ccuuccucac ucaguuguuc     1260

ugcugcuuuc agacccccga ucgucuguuu uuugugaugg aguuugugaa ugggggugac     1320

uugauguucc acauucagaa gucucgucgu uuugaugaag cacgagcucg cuucuaugcu     1380

gcagaaauca uuucggcucu cauguuccuc caugauaaag gaaucaucua uagagaucug     1440

aaacuggaca auguccuguu ggaccacgag ggucacugua aacuggcaga cuucggaaug     1500

ugcaaggagg ggauuugcaa uggugucacc acggccacau ucuguggcac gccagacuau     1560

aucgcuccag agauccucca ggaaaugcug uacgggccug caguagacug gugggcaaug     1620

ggcguguugc ucuaugagau gcucuguggu cacgcgccuu uugaggcaga gaaugaagau     1680

gaccucuuug aggccauacu gaaugaugag guggucuacc cuaccuggcu ccaugaagau     1740

gccacaggga uccuaaaauc uuucaugacc aagaacccca ccaugcgcuu gggcagccug     1800

acucagggag gcgagcacgc caucuugaga cauccuuuuu uuaaggaaau cgacugggcc     1860

cagcugaacc aucgccaaau agaaccgccu uucagaccca gaaucaaauc ccgagaagau     1920

gucaguaauu uugacccuga cuucauaaag gaagagccag uuuuaacucc aauugaugag     1980

ggacaucuuc caaugauuaa ccaggaugag uuuagaaacu uuuccuaugu gucuccagaa     2040

uugcaaccau ag                                                         2052


<210>  8901
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCL__Homo_sapiens__AAH37268

<400>  8901
augagcuccg gcaccaugaa guucaacggg uaccugcgcg ugcggaucgg cgaggccguc       60

gggcuccagc ccacccgcug gagccugcgg cacucccugu ucaagaaggg ccaccagcuc      120

cuggacccgu accugacggu gagcguggac cagguccgcg uggggcagac cuccaccaag      180

cagaagacca acaagcccac guacaacgag gaguucugcg ccaacgugac cgacggcggc      240

caccucgagc uggcggucuu ccacgagacg ccccuggggu acgaccacuu cguggccaac      300

ugcacccucc aguuccagga gcugcugcgg accaccggcg ccagcgacac cuucgagggg      360

uggguggacc ucgagcccga gggcaagguc uucgugguga ucacccugac gggguccuuc      420

accgaggcca cccugcagcg cgaccggauc uucaagcacu ucacccgcaa gcggcagcgc      480

gccaugcggc gccgggucca ccagaucaac ggccacaagu ucauggcgac guaccuccgc      540

cagccgaccu acugcagcca cugccgggag uucaucuggg gcguguucgg gaagcagggc      600

uaccagugcc aggugugcac gugcgucgug cacaagcgcu gccaccaccu gaucgugacc      660

gccugcacgu gccagaacaa caucaacaag gucgacucca agaucgccga gcagcgguuc      720

gggaucaaca ucccccacaa guucagcauc cacaacuaca aggugcccac cuucugcgac      780

cacugcggcu cccugcucug gggcaucaug cgccaggggc ugcagugcaa gaucugcaag      840

augaacgugc acauccggug ccaggccaac gucgcgccca acugcggcgu gaacgccgug      900

gagcuggcca agacccucgc cgggaugggc cugcagccgg ggaacaucag ccccaccucc      960

aagcugguca gccgcuccac ccuccggcgc cagggcaagg agagcuccaa ggagggcaac     1020

gggaucggcg ugaacagcuc caaccgccug gggaucgaca acuucgaguu cauccggguc     1080

cugggcaagg ggagcuucgg caaggugaug cucgcccgcg ugaaggagac cggcgaccug     1140

uacgcgguca aggugcugaa gaaggacgug auccuccagg acgacgacgu cgagugcacc     1200

augaccgaga agcggauccu gagccuggcc cgcaaccacc ccuuccucac gcagcuguuc     1260

ugcugcuucc agacccccga ccggcuguuc uucgugaugg aguucgugaa cgggggcgac     1320

cucauguucc acauccagaa gucccgccgg uucgacgagg cccgcgcccg guucuacgcc     1380

gcggagauca ucagcgcccu gauguuccug cacgacaagg ggaucaucua ccgcgaccuc     1440

aagcuggaca acguccugcu cgaccacgag ggccacugca agcuggccga cuucgggaug     1500

ugcaaggagg gcaucugcaa cggcgugacc accgccacgu ucugcgggac cccggacuac     1560

aucgcccccg agauccugca ggagaugcuc uacggccccg cgguggacug gugggccaug     1620

gggguccugc uguacgagau gcucugcggc cacgcccccu ucgaggccga gaacgaggac     1680

gaccuguucg aggccauccu gaacgacgag gugguguacc cgaccuggcu gcacgaggac     1740

gcgaccggca uccucaaguc cuucaugacg aagaacccca ccaugcggcu ggggagccug     1800

acccagggcg gggagcacgc cauccuccgc caccccuucu ucaaggagau cgacugggcc     1860

cagcugaacc accggcagau cgagcccccg uuccgccccc ggaucaaguc ccgcgaggac     1920

gucagcaacu ucgaccccga cuucaucaag gaggagcccg ugcugacccc gaucgacgag     1980

ggccaccucc ccaugaucaa ccaggacgag uuccggaacu ucuccuacgu gagccccgag     2040

cugcagcccu ga                                                         2052


<210>  8902
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCL__Homo_sapiens__AAH37268

<400>  8902
auguccuccg gcaccaugaa guucaacggc uaccuccgcg uccgcaucgg cgaggccguc       60

ggccuccagc ccacccgcug gucccuccgc cacucccucu ucaagaaggg ccaccagcuc      120

cucgaccccu accucaccgu cuccgucgac cagguccgcg ucggccagac cuccaccaag      180

cagaagacca acaagcccac cuacaacgag gaguucugcg ccaacgucac cgacggcggc      240

caccucgagc ucgccgucuu ccacgagacc ccccucggcu acgaccacuu cgucgccaac      300

ugcacccucc aguuccagga gcuccuccgc accaccggcg ccuccgacac cuucgagggc      360

ugggucgacc ucgagcccga gggcaagguc uucgucguca ucacccucac cggcuccuuc      420

accgaggcca cccuccagcg cgaccgcauc uucaagcacu ucacccgcaa gcgccagcgc      480

gccaugcgcc gccgcgucca ccagaucaac ggccacaagu ucauggccac cuaccuccgc      540

cagcccaccu acugcuccca cugccgcgag uucaucuggg gcgucuucgg caagcagggc      600

uaccagugcc aggucugcac cugcgucguc cacaagcgcu gccaccaccu caucgucacc      660

gccugcaccu gccagaacaa caucaacaag gucgacucca agaucgccga gcagcgcuuc      720

ggcaucaaca ucccccacaa guucuccauc cacaacuaca agguccccac cuucugcgac      780

cacugcggcu cccuccucug gggcaucaug cgccagggcc uccagugcaa gaucugcaag      840

augaacgucc acauccgcug ccaggccaac gucgccccca acugcggcgu caacgccguc      900

gagcucgcca agacccucgc cggcaugggc cuccagcccg gcaacaucuc ccccaccucc      960

aagcucgucu cccgcuccac ccuccgccgc cagggcaagg aguccuccaa ggagggcaac     1020

ggcaucggcg ucaacuccuc caaccgccuc ggcaucgaca acuucgaguu cauccgcguc     1080

cucggcaagg gcuccuucgg caaggucaug cucgcccgcg ucaaggagac cggcgaccuc     1140

uacgccguca agguccucaa gaaggacguc auccuccagg acgacgacgu cgagugcacc     1200

augaccgaga agcgcauccu cucccucgcc cgcaaccacc ccuuccucac ccagcucuuc     1260

ugcugcuucc agacccccga ccgccucuuc uucgucaugg aguucgucaa cggcggcgac     1320

cucauguucc acauccagaa gucccgccgc uucgacgagg cccgcgcccg cuucuacgcc     1380

gccgagauca ucuccgcccu cauguuccuc cacgacaagg gcaucaucua ccgcgaccuc     1440

aagcucgaca acguccuccu cgaccacgag ggccacugca agcucgccga cuucggcaug     1500

ugcaaggagg gcaucugcaa cggcgucacc accgccaccu ucugcggcac ccccgacuac     1560

aucgcccccg agauccucca ggagaugcuc uacggccccg ccgucgacug gugggccaug     1620

ggcguccucc ucuacgagau gcucugcggc cacgcccccu ucgaggccga gaacgaggac     1680

gaccucuucg aggccauccu caacgacgag gucgucuacc ccaccuggcu ccacgaggac     1740

gccaccggca uccucaaguc cuucaugacc aagaacccca ccaugcgccu cggcucccuc     1800

acccagggcg gcgagcacgc cauccuccgc caccccuucu ucaaggagau cgacugggcc     1860

cagcucaacc accgccagau cgagcccccc uuccgccccc gcaucaaguc ccgcgaggac     1920

gucuccaacu ucgaccccga cuucaucaag gaggagcccg uccucacccc caucgacgag     1980

ggccaccucc ccaugaucaa ccaggacgag uuccgcaacu ucuccuacgu cucccccgag     2040

cuccagcccu ga                                                         2052


<210>  8903
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCL__Homo_sapiens__AAH37268

<400>  8903
augagcuccg gcaccaugaa guucaacggg uaccugagag ugaggaucgg agaggccguc       60

ggucuccagc ccacacggug gucucuucgc cacucacugu uuaaaaaggg ccaucaauug      120

uuagacccuu aucugacugu uaguguggau cagguacgag uggggcagac gagcaccaaa      180

cagaagacaa auaaaccaac uuacaacgaa gaguucugcg cuaaugucac cgacggaggc      240

caccuagaac ucgcaguguu ucaugagaca ccgcuggguu augaucacuu cguugccaac      300

uguacccuuc aauuucagga acuguugcgu acuacagggg cguccgacac cuucgaggga      360

uggguggauc ucgagcccga aggcaagguc uuugugguaa uuacgcugac uggcucuuuc      420

accgaggcua cacugcagag agacaggaua uuuaagcauu ucacucggaa acgccagaga      480

gccaugaggc ggcgcguuca ccaaaucaau gggcacaagu uuauggcaac cuaccuccga      540

cagccuacau auugcucgca uuguagagag uucauuuggg gaguguuugg uaaacagggc      600

uaccagugcc aagucuguac cugcguggug cacaagaggu gucaucacuu aaucgucacg      660

gccugcacuu gucagaacaa uauuaacaaa guugauucaa agaucgcuga acagcgguuc      720

gggauaaaua ucccacacaa guucagcauu cauaacuaua aagugcccac auuuugcgac      780

cacuguggaa gucugcuuug gggcaucaug cgucaagguu ugcagugcaa gauuugcaaa      840

augaauguac auauccgcug ucaggcaaac guggccccua auugcggggu caacgcugug      900

gagcuggcca agacccuagc gggaaugggc cuccagccag gcaauauauc ccccacuucu      960

aaacugguua gcagauccac acuuaggcgg caagggaagg aaucaaguaa agagggaaac     1020

gguauuggcg ugaacagcuc uaaucgacug gggaucgaua acuucgaauu uauucgcguc     1080

uugggaaagg gcuccuucgg uaaggugaug cucgcaagag uaaaagagac cggggaccug     1140

uacgccguua aggugcugaa aaaggauguc auccugcagg acgaugacgu ggaauguacg     1200

augaccgaga aaaggauccu cucacuugcu cggaaucacc cuuuucugac acaguuguuc     1260

ugcuguuuuc agacuccaga ccgccuauuc uuugucaugg aguucgugaa cggcggagau     1320

cugauguuuc auauucaaaa gagcagaagg uucgacgaag cccgugcacg guuuuacgcu     1380

gccgagauaa ucagugcgcu cauguuccug cacgauaagg gcauuaucua ucgagaccuu     1440

aaacuggaua auguuuugcu cgaccacgaa gggcauugca agcuggccga uuucggaaug     1500

uguaaagagg guauaugcaa cggcgugacc acagcaacuu uuugugggac cccggacuac     1560

auugcucccg aaaucuuaca ggagaugcug uauggaccug ccguagauug gugggcuaug     1620

ggcguccuac ucuacgagau gcugugcggu cacgccccau ucgaagcaga gaaugaagac     1680

gaucuuuuug aggccaucuu gaacgacgaa gugguuuauc ccacauggcu gcaugaggac     1740

gcuaccggga uucucaaguc uuucaugacu aaaaauccua cgaugagacu gggcucccuu     1800

acacagggag gcgagcacgc gauccugagg cacccauuuu ucaaggaaau ugauugggca     1860

caguugaacc aucgccaaau agagcccccg uuucggccua gaaucaagag cagggaagac     1920

gugucgaauu ucgaucccga cuuuauuaaa gaggagccag uccucacccc uaucgaugaa     1980

gggcacuuac ccaugaucaa ccaggacgag uuccgcaauu uuucuuacgu guccccagaa     2040

uuacagcccu ga                                                         2052


<210>  8904
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCL__Homo_sapiens__AAH37268

<400>  8904
augagcagcg gcaccaugaa guucaacggc uaccugagag ugagaaucgg cgaggccgug       60

ggccugcagc ccaccagaug gagccugaga cacagccugu ucaagaaggg ccaccagcug      120

cuggaccccu accugaccgu gagcguggac caggugagag ugggccagac cagcaccaag      180

cagaagacca acaagcccac cuacaacgag gaguucugcg ccaacgugac cgacggcggc      240

caccuggagc uggccguguu ccacgagacc ccccugggcu acgaccacuu cguggccaac      300

ugcacccugc aguuccagga gcugcugaga accaccggcg ccagcgacac cuucgagggc      360

uggguggacc uggagcccga gggcaaggug uucgugguga ucacccugac cggcagcuuc      420

accgaggcca cccugcagag agacagaauc uucaagcacu ucaccagaaa gagacagaga      480

gccaugagaa gaagagugca ccagaucaac ggccacaagu ucauggccac cuaccugaga      540

cagcccaccu acugcagcca cugcagagag uucaucuggg gcguguucgg caagcagggc      600

uaccagugcc aggugugcac cugcguggug cacaagagau gccaccaccu gaucgugacc      660

gccugcaccu gccagaacaa caucaacaag guggacagca agaucgccga gcagagauuc      720

ggcaucaaca ucccccacaa guucagcauc cacaacuaca aggugcccac cuucugcgac      780

cacugcggca gccugcugug gggcaucaug agacagggcc ugcagugcaa gaucugcaag      840

augaacgugc acaucagaug ccaggccaac guggccccca acugcggcgu gaacgccgug      900

gagcuggcca agacccuggc cggcaugggc cugcagcccg gcaacaucag ccccaccagc      960

aagcugguga gcagaagcac ccugagaaga cagggcaagg agagcagcaa ggagggcaac     1020

ggcaucggcg ugaacagcag caacagacug ggcaucgaca acuucgaguu caucagagug     1080

cugggcaagg gcagcuucgg caaggugaug cuggccagag ugaaggagac cggcgaccug     1140

uacgccguga aggugcugaa gaaggacgug auccugcagg acgacgacgu ggagugcacc     1200

augaccgaga agagaauccu gagccuggcc agaaaccacc ccuuccugac ccagcuguuc     1260

ugcugcuucc agacccccga cagacuguuc uucgugaugg aguucgugaa cggcggcgac     1320

cugauguucc acauccagaa gagcagaaga uucgacgagg ccagagccag auucuacgcc     1380

gccgagauca ucagcgcccu gauguuccug cacgacaagg gcaucaucua cagagaccug     1440

aagcuggaca acgugcugcu ggaccacgag ggccacugca agcuggccga cuucggcaug     1500

ugcaaggagg gcaucugcaa cggcgugacc accgccaccu ucugcggcac ccccgacuac     1560

aucgcccccg agauccugca ggagaugcug uacggccccg ccguggacug gugggccaug     1620

ggcgugcugc uguacgagau gcugugcggc cacgcccccu ucgaggccga gaacgaggac     1680

gaccuguucg aggccauccu gaacgacgag gugguguacc ccaccuggcu gcacgaggac     1740

gccaccggca uccugaagag cuucaugacc aagaacccca ccaugagacu gggcagccug     1800

acccagggcg gcgagcacgc cauccugaga caccccuucu ucaaggagau cgacugggcc     1860

cagcugaacc acagacagau cgagcccccc uucagaccca gaaucaagag cagagaggac     1920

gugagcaacu ucgaccccga cuucaucaag gaggagcccg ugcugacccc caucgacgag     1980

ggccaccugc ccaugaucaa ccaggacgag uucagaaacu ucagcuacgu gagccccgag     2040

cugcagcccu ga                                                         2052


<210>  8905
<211>  2052
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCL__Homo_sapiens__AAH37268

<400>  8905
augagcuccg gcaccaugaa guucaacggg uaccugagag ugcggaucgg agaggccguc       60

ggccuccagc ccacacgcug gucucugaga cacagccuuu uuaaaaaggg gcaccaacug      120

cucgacccuu aucugacggu uuccguggau caggugcggg ucggacagac cucuacaaaa      180

cagaagacca auaaaccgac auacaacgaa gaguucugcg cuaaugugac cgacggcggg      240

caccuugaac uggccguuuu ucaugagaca ccccucggau augaucacuu cguggcgaac      300

uguacccugc aauuucagga acugcuccgc acgaccggcg cuagcgacac auucgagggc      360

ugggucgauc uggagccuga agggaaggug uuuguuguga uuacccuuac aggauccuuc      420

accgaggcca cgcugcagag agaccggauc uuuaagcauu ucacacgcaa aagacagcgg      480

gccaugcgca gacgggucca ccaaauuaau ggccacaagu uuauggcuac cuaccuccgc      540

cagcccacau auugcucuca uuguagagag uucaucuggg gaguguuugg gaaacagggc      600

uaccagugcc aaguguguac cugcgucguu cacaagcggu gucaucaccu gauugugacc      660

gccugcacau gucagaacaa uaucaacaaa guggauagca agaucgcuga acagcgcuuc      720

gggauuaaua ucccucacaa guucuccauu cauaacuaua aaguccccac guuuugcgac      780

cacuguggaa gccuucugug gggcaucaug agacaaggcc uccagugcaa gauuugcaaa      840

augaaugugc auauccggug ucaggccaac guugcgccua auugcggggu gaacgccguc      900

gagcuggcua agacccuggc cggaaugggc cuccagccgg ggaauauuuc ucccacaucc      960

aaacugguga gcagaucuac ccuucgccgg caaggaaagg aauccagcaa agagggcaac     1020

gggaucggag uuaacucuuc caauagacug ggcaucgaua acuucgaauu uauucgcgug     1080

cucggcaagg ggagcuucgg aaaggucaug cuggcucggg ugaaagagac aggcgaccuu     1140

uacgccguca aggugcugaa aaaggauguu auccuccagg acgaugacgu ggaauguacc     1200

augacggaga aacgcauucu gucccuggcg agaaaucacc cuuuucucac acagcuguuc     1260

ugcuguuuuc agacccccga ccggcuuuuc uuugucaugg aguucgugaa cgggggagau     1320

cugauguuuc auauccaaaa gucuagacgc uucgacgaag cccgggcuag auuuuacgcc     1380

gcugagauua ucagcgcccu cauguuccug cacgauaagg gcaucauuua ucgcgaccuu     1440

aaacuggaua auguucuccu ggaccacgaa gggcauugca agcuggccga uuucggcaug     1500

uguaaagagg gaaucugcaa cggcgugacc acagcuaccu uuugugggac accugacuac     1560

auugcgcccg aaauccucca ggagaugcug uauggaccgg ccgucgauug gugggcuaug     1620

ggcgugcuuc uguacgagau gcucugcggg cacgccccuu ucgaagccga gaaugaagac     1680

gaucuguuug aggcuauucu gaacgacgaa gugguuuauc ccacguggcu ucaugaggac     1740

gccaccggaa uccucaaguc cuucaugacc aaaaauccua caaugcggcu gggcagccug     1800

acacaagggg gcgagcacgc gauccucaga caccccuuuu ucaaggaaau ugauugggcu     1860

cagcugaacc aucggcagau cgagcccccu uuucgcccga gaauuaaguc ucgggaagac     1920

gucuccaauu ucgaucccga cuuuaucaaa gaggagccug ugcuuacccc cauugaugaa     1980

ggacaucugc cuaugaucaa ccaggacgag uucagaaauu uuagcuacgu gucucccgaa     2040

cuccagccgu ga                                                         2052


<210>  8906
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCT__Homo_sapiens__Q04759

<400>  8906

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  8907
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCT__Homo_sapiens__AAA60101

<400>  8907
augucgccau uucuucggau uggcuugucc aacuuugacu gcggguccug ccagucuugu       60

cagggcgagg cuguuaaccc uuacugugcu gugcucguca aagaguaugu cgaaucagag      120

aacgggcaga uguauaucca gaaaaagccu accauguacc cacccuggga cagcacuuuu      180

gaugcccaua ucaacaaggg aagagucaug cagaucauug ugaaaggcaa aaacguggac      240

cucaucucug aaaccaccgu ggagcucuac ucgcuggcug agaggugcag gaagaacaac      300

gggaagacag aaauaugguu agagcugaaa ccucaaggcc gaaugcuaau gaaugcaaga      360

uacuuucugg aaaugaguga cacaaaggac augaaugaau uugagacgga aggcuucuuu      420

gcuuugcauc agcgccgggg ugccaucaag caggcaaagg uccaccacgu caagugccac      480

gaguucacug ccaccuucuu cccacagccc acauuuugcu cugucugcca cgaguuuguc      540

uggggccuga acaaacaggg cuaccagugc cgacaaugca augcagcaau ucacaagaag      600

uguauugaua aaguuauagc aaagugcaca ggaucagcua ucaauagccg agaaaccaug      660

uuccacaagg agagauucaa aauugacaug ccacacagau uuaaagucua caauuacaag      720

agcccgaccu ucugugaaca cugugggacc cugcuguggg gacuggcacg gcaaggacuc      780

aagugugaug cauguggcau gaaugugcau cauagaugcc agacaaaggu ggccaaccuu      840

uguggcauaa accagaagcu aauggcugaa gcgcuggcca ugauugagag cacucaacag      900

gcucgcugcu uaagagauac ugaacagauc uucagagaag guccgguuga aauuggucuc      960

ccaugcucca ucaaaaauga agcaaggccg ccauguuuac cgacaccggg aaaaagagag     1020

ccucagggca uuuccuggga gucuccguug gaugaggugg auaaaaugug ccaucuucca     1080

gaaccugaac ugaacaaaga aagaccaucu cugcagauua aacuaaaaau ugaggauuuu     1140

aucuugcaca aaauguuggg gaaaggaagu uuuggcaagg ucuuccuggc agaauucaag     1200

aaaaccaauc aauuuuucgc aauaaaggcc uuaaagaaag auguggucuu gauggacgau     1260

gauguugagu gcacgauggu agagaagaga guucuuuccu uggccuggga gcauccguuu     1320

cugacgcaca uguuuuguac auuccagacc aaggaaaacc ucuuuuuugu gauggaguac     1380

cucaacggag gggacuuaau guaccacauc caaagcugcc acaaguucga ccuuuccaga     1440

gcgacguuuu augcugcuga aaucauucuu ggucugcagu uccuucauuc caaaggaaua     1500

gucuacaggg accugaagcu agauaacauc cuguuagaca aagauggaca uaucaagauc     1560

gcggauuuug gaaugugcaa ggagaacaug uuaggagaug ccaagacgaa uaccuucugu     1620

gggacaccug acuacaucgc cccagagauc uugcuggguc agaaauacaa ccacucugug     1680

gacugguggu ccuucggggu ucuccuuuau gaaaugcuga uuggucaguc gccuuuccac     1740

gggcaggaug aggaggagcu cuuccacucc auccgcaugg acaaucccuu uuacccacgg     1800

uggcuggaga aggaagcaaa ggaccuucug gugaagcucu ucgugcgaga accugagaag     1860

aggcugggcg ugaggggaga cauccgccag cacccuuugu uucgggagau caacugggag     1920

gaacuugaac ggaaggagau ugacccaccg uuccggccga aagugaaauc accauuugac     1980

ugcagcaauu ucgacaaaga auucuuaaac gagaagcccc ggcugucauu ugccgacaga     2040

gcacugauca acagcaugga ccagaauaug uucaggaacu uuuccuucau gaaccccggg     2100

auggagcggc ugauauccug a                                               2121


<210>  8908
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCT__Homo_sapiens__AAA60101

<400>  8908
augagccccu uccugcgcau cggccucucc aacuucgacu gcgggagcug ccaguccugc       60

cagggcgagg ccgugaaccc guacugcgcc gugcugguga aggaguacgu ggagagcgag      120

aacgggcaga uguacaucca gaagaagccc accauguacc cgcccuggga cuccaccuuc      180

gacgcgcaca ucaacaaggg ccgggucaug cagaucaucg ugaaggggaa gaacguggac      240

cugaucagcg agacgaccgu cgagcucuac ucccuggccg agcgcugccg gaagaacaac      300

ggcaagaccg agaucuggcu ggagcucaag ccccagggcc gcaugcugau gaacgcccgg      360

uacuuccugg agaugagcga caccaaggac augaacgagu ucgagacgga gggguucuuc      420

gcccuccacc agcgccgggg cgccaucaag caggcgaagg ugcaccacgu gaagugccac      480

gaguucaccg ccaccuucuu cccccagccc accuucugcu ccgucugcca cgaguucgug      540

ugggggcuga acaagcaggg cuaccagugc cgccagugca acgccgccau ccacaagaag      600

ugcaucgaca aggugaucgc gaagugcacg gggagcgcca ucaacucccg ggagaccaug      660

uuccacaagg agcgcuucaa gaucgacaug ccccaccggu ucaaggucua caacuacaag      720

agcccgaccu ucugcgagca cugcggcacc cugcucuggg gccuggcccg ccaggggcug      780

aagugcgacg ccugcggcau gaacgugcac caccggugcc agacgaaggu ggccaaccuc      840

ugcgggauca accagaagcu gauggcggag gcccuggcca ugaucgaguc cacccagcag      900

gcccgcugcc uccgggacac cgagcagauc uuccgcgagg gccccgucga gaucggccug      960

cccugcagca ucaagaacga ggcccggccc ccgugccugc ccacccccgg gaagcgcgag     1020

ccccagggca ucuccuggga gagcccgcuc gacgaggugg acaagaugug ccaccucccc     1080

gagcccgagc ugaacaagga gcggcccucc cuccagauca agcugaagau cgaggacuuc     1140

auccugcaca agaugcucgg gaagggcagc uucgggaagg uguuccuggc ggaguucaag     1200

aagacgaacc aguucuucgc caucaaggcc cugaagaagg acgucgugcu cauggacgac     1260

gacguggagu gcaccauggu cgagaagcgc gugcuguccc uggccuggga gcacccguuc     1320

cucacccaca uguucugcac cuuccagacg aaggagaacc uguucuucgu gauggaguac     1380

cugaacggcg gcgaccucau guaccacauc cagagcugcc acaaguucga ccugagccgg     1440

gccaccuucu acgcggccga gaucauccug gggcuccagu uccugcacuc caagggcauc     1500

gucuaccgcg accugaagcu cgacaacauc cugcuggaca aggacgggca caucaagauc     1560

gccgacuucg gcaugugcaa ggagaacaug cucggggacg ccaagaccaa caccuucugc     1620

ggcacgcccg acuacaucgc ccccgagauc cugcugggcc agaaguacaa ccacagcgug     1680

gacugguggu ccuucggggu ccuccuguac gagaugcuga ucggccagag ccccuuccac     1740

gggcaggacg aggaggagcu guuccacucc auccgcaugg acaacccguu cuacccccgg     1800

uggcucgaga aggaggcgaa ggaccugcug gugaagcugu ucgugcgcga gcccgagaag     1860

cggcugggcg uccgcgggga cauccggcag cacccccugu uccgcgagau caacugggag     1920

gagcucgagc ggaaggagau cgacccgccc uuccgcccca aggucaagag cccguucgac     1980

ugcuccaacu ucgacaagga guuccugaac gagaagcccc ggcugagcuu cgccgaccgc     2040

gcccucauca acuccaugga ccagaacaug uuccggaacu ucagcuucau gaaccccggc     2100

auggagcgcc ugaucuccug a                                               2121


<210>  8909
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCT__Homo_sapiens__AAA60101

<400>  8909
augucccccu uccuccgcau cggccucucc aacuucgacu gcggcuccug ccaguccugc       60

cagggcgagg ccgucaaccc cuacugcgcc guccucguca aggaguacgu cgaguccgag      120

aacggccaga uguacaucca gaagaagccc accauguacc cccccuggga cuccaccuuc      180

gacgcccaca ucaacaaggg ccgcgucaug cagaucaucg ucaagggcaa gaacgucgac      240

cucaucuccg agaccaccgu cgagcucuac ucccucgccg agcgcugccg caagaacaac      300

ggcaagaccg agaucuggcu cgagcucaag ccccagggcc gcaugcucau gaacgcccgc      360

uacuuccucg agauguccga caccaaggac augaacgagu ucgagaccga gggcuucuuc      420

gcccuccacc agcgccgcgg cgccaucaag caggccaagg uccaccacgu caagugccac      480

gaguucaccg ccaccuucuu cccccagccc accuucugcu ccgucugcca cgaguucguc      540

uggggccuca acaagcaggg cuaccagugc cgccagugca acgccgccau ccacaagaag      600

ugcaucgaca aggucaucgc caagugcacc ggcuccgcca ucaacucccg cgagaccaug      660

uuccacaagg agcgcuucaa gaucgacaug ccccaccgcu ucaaggucua caacuacaag      720

ucccccaccu ucugcgagca cugcggcacc cuccucuggg gccucgcccg ccagggccuc      780

aagugcgacg ccugcggcau gaacguccac caccgcugcc agaccaaggu cgccaaccuc      840

ugcggcauca accagaagcu cauggccgag gcccucgcca ugaucgaguc cacccagcag      900

gcccgcugcc uccgcgacac cgagcagauc uuccgcgagg gccccgucga gaucggccuc      960

cccugcucca ucaagaacga ggcccgcccc cccugccucc ccacccccgg caagcgcgag     1020

ccccagggca ucuccuggga guccccccuc gacgaggucg acaagaugug ccaccucccc     1080

gagcccgagc ucaacaagga gcgccccucc cuccagauca agcucaagau cgaggacuuc     1140

auccuccaca agaugcucgg caagggcucc uucggcaagg ucuuccucgc cgaguucaag     1200

aagaccaacc aguucuucgc caucaaggcc cucaagaagg acgucguccu cauggacgac     1260

gacgucgagu gcaccauggu cgagaagcgc guccucuccc ucgccuggga gcaccccuuc     1320

cucacccaca uguucugcac cuuccagacc aaggagaacc ucuucuucgu cauggaguac     1380

cucaacggcg gcgaccucau guaccacauc caguccugcc acaaguucga ccucucccgc     1440

gccaccuucu acgccgccga gaucauccuc ggccuccagu uccuccacuc caagggcauc     1500

gucuaccgcg accucaagcu cgacaacauc cuccucgaca aggacggcca caucaagauc     1560

gccgacuucg gcaugugcaa ggagaacaug cucggcgacg ccaagaccaa caccuucugc     1620

ggcacccccg acuacaucgc ccccgagauc cuccucggcc agaaguacaa ccacuccguc     1680

gacugguggu ccuucggcgu ccuccucuac gagaugcuca ucggccaguc ccccuuccac     1740

ggccaggacg aggaggagcu cuuccacucc auccgcaugg acaaccccuu cuacccccgc     1800

uggcucgaga aggaggccaa ggaccuccuc gucaagcucu ucguccgcga gcccgagaag     1860

cgccucggcg uccgcggcga cauccgccag cacccccucu uccgcgagau caacugggag     1920

gagcucgagc gcaaggagau cgaccccccc uuccgcccca aggucaaguc ccccuucgac     1980

ugcuccaacu ucgacaagga guuccucaac gagaagcccc gccucuccuu cgccgaccgc     2040

gcccucauca acuccaugga ccagaacaug uuccgcaacu ucuccuucau gaaccccggc     2100

auggagcgcc ucaucuccug a                                               2121


<210>  8910
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCT__Homo_sapiens__AAA60101

<400>  8910
augagccccu uccugagaau cggccucucc aacuuugacu gcgggucuug ucagucaugc       60

caaggagagg ccgugaaucc uuacugugcu guccuuguua aggaauaugu ggagagugaa      120

aacggucaga uguacauuca gaaaaagcca accauguauc cgcccuggga uagcacauuc      180

gacgcacaca uaaauaaagg caggguaaug cagaucauug ugaaggggaa aaacgucgau      240

cugaucuccg agacuacggu ggaauuguac ucuuuagccg agcggugccg caagaauaac      300

ggaaagaccg agauuuggcu ggaacuaaaa ccucaaggcc gaaugcucau gaaugcgcgu      360

uauuuucugg agaugucgga cacaaaggau augaacgagu ucgaaacuga gggguuuuuc      420

gcccuucauc agagaagggg ugcuaucaaa caggcaaagg uucaccaugu gaaaugucac      480

gaauuuaccg ccacauucuu uccacagccc accuucugcu cagucuguca ugaguuugug      540

uggggacuga auaagcaagg cuaccagugc cggcagugua acgcugcaau acacaagaaa      600

ugcaucgaca agguaauugc caaauguacu ggcagcgcua ucaauagucg cgaaacaaug      660

uuccacaagg agagauuuaa aauugauaug ccucauaggu ucaagguuua uaacuacaaa      720

uccccaaccu ucugcgaaca cugcgggacg uugcucuggg gacuggcccg gcagggucug      780

aagugugacg cgugcggcau gaaugugcau caccgcuguc aaacuaaggu cgcaaaccuc      840

ugcgggauca aucagaaauu aauggccgag gcucuggcca ugauagaguc uacccagcaa      900

gcacgauguc uuagagauac agaacagauu uuuagggagg gacccgugga aaucggcuug      960

ccuugcagca uuaagaacga ggcucggcca ccgugucugc ccacuccugg uaaacgugaa     1020

ccacagggga ucuccuggga gucaccccua gacgaggugg auaagaugug ccaccucccu     1080

gaaccagagc ugaacaaaga acgccccagu cuucagauca agcugaagau ugaggacuuc     1140

auauugcaua aaaugcucgg aaagggcagc uuuggcaaag ucuuccuggc cgaauuuaag     1200

aaaaccaauc aauucuuugc gaucaaggcc uuaaagaaag auguugugcu gauggacgac     1260

gauguagagu guacaauggu ggagaagaga guccucucuc uugcauggga acacccguuc     1320

cugacccaua uguuuugcac guuccagacu aaagagaacu uguuuuucgu gauggaauac     1380

cuaaaugggg gagaccugau guaucacauu caguccuguc auaaguuuga ucucucaagg     1440

gcuacauucu acgccgcuga gaucauacug ggucuucagu uccugcacag caaaggcauu     1500

guuuaucggg acuugaagcu cgauaacauc cuguuagaca aggaugggca caucaaaauu     1560

gccgacuuug gaaugugcaa ggagaauaug cugggcgaug caaaaaccaa cacuuucugc     1620

gguacaccug acuacaucgc ccccgaaauu cuacucgggc aaaaguauaa ucauagugug     1680

gauugguggu cuuuuggcgu ccugcuuuac gagauguuga uaggacaguc cccauuccac     1740

ggccaggacg aagaggaacu guuucauagc auccgaaugg acaacccuuu cuauccccgc     1800

uggcucgaga aagaggcuaa ggaucugcuu gugaaacugu uuguaagaga accagagaag     1860

agguuggggg uucggggaga cauucgccag cacccccucu ucagagaaau caauugggag     1920

gaacuggaga ggaaggagau cgauccucca uuucguccga aagugaaguc gcccuucgac     1980

uguucuaacu uugauaaaga guucuuaaau gaaaagccuc ggcuguccuu ugcggaccga     2040

gcacuaauua acucaaugga ucaaaauaug uucagaaacu ucaguuuuau gaauccaggu     2100

auggaaaggc ucauaagcug a                                               2121


<210>  8911
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCT__Homo_sapiens__AAA60101

<400>  8911
augagccccu uccugagaau cggccugagc aacuucgacu gcggcagcug ccagagcugc       60

cagggcgagg ccgugaaccc cuacugcgcc gugcugguga aggaguacgu ggagagcgag      120

aacggccaga uguacaucca gaagaagccc accauguacc cccccuggga cagcaccuuc      180

gacgcccaca ucaacaaggg cagagugaug cagaucaucg ugaagggcaa gaacguggac      240

cugaucagcg agaccaccgu ggagcuguac agccuggccg agagaugcag aaagaacaac      300

ggcaagaccg agaucuggcu ggagcugaag ccccagggca gaaugcugau gaacgccaga      360

uacuuccugg agaugagcga caccaaggac augaacgagu ucgagaccga gggcuucuuc      420

gcccugcacc agagaagagg cgccaucaag caggccaagg ugcaccacgu gaagugccac      480

gaguucaccg ccaccuucuu cccccagccc accuucugca gcgugugcca cgaguucgug      540

uggggccuga acaagcaggg cuaccagugc agacagugca acgccgccau ccacaagaag      600

ugcaucgaca aggugaucgc caagugcacc ggcagcgcca ucaacagcag agagaccaug      660

uuccacaagg agagauucaa gaucgacaug ccccacagau ucaaggugua caacuacaag      720

agccccaccu ucugcgagca cugcggcacc cugcuguggg gccuggccag acagggccug      780

aagugcgacg ccugcggcau gaacgugcac cacagaugcc agaccaaggu ggccaaccug      840

ugcggcauca accagaagcu gauggccgag gcccuggcca ugaucgagag cacccagcag      900

gccagaugcc ugagagacac cgagcagauc uucagagagg gccccgugga gaucggccug      960

cccugcagca ucaagaacga ggccagaccc cccugccugc ccacccccgg caagagagag     1020

ccccagggca ucagcuggga gagcccccug gacgaggugg acaagaugug ccaccugccc     1080

gagcccgagc ugaacaagga gagacccagc cugcagauca agcugaagau cgaggacuuc     1140

auccugcaca agaugcuggg caagggcagc uucggcaagg uguuccuggc cgaguucaag     1200

aagaccaacc aguucuucgc caucaaggcc cugaagaagg acguggugcu gauggacgac     1260

gacguggagu gcaccauggu ggagaagaga gugcugagcc uggccuggga gcaccccuuc     1320

cugacccaca uguucugcac cuuccagacc aaggagaacc uguucuucgu gauggaguac     1380

cugaacggcg gcgaccugau guaccacauc cagagcugcc acaaguucga ccugagcaga     1440

gccaccuucu acgccgccga gaucauccug ggccugcagu uccugcacag caagggcauc     1500

guguacagag accugaagcu ggacaacauc cugcuggaca aggacggcca caucaagauc     1560

gccgacuucg gcaugugcaa ggagaacaug cugggcgacg ccaagaccaa caccuucugc     1620

ggcacccccg acuacaucgc ccccgagauc cugcugggcc agaaguacaa ccacagcgug     1680

gacuggugga gcuucggcgu gcugcuguac gagaugcuga ucggccagag ccccuuccac     1740

ggccaggacg aggaggagcu guuccacagc aucagaaugg acaaccccuu cuaccccaga     1800

uggcuggaga aggaggccaa ggaccugcug gugaagcugu ucgugagaga gcccgagaag     1860

agacugggcg ugagaggcga caucagacag cacccccugu ucagagagau caacugggag     1920

gagcuggaga gaaaggagau cgaccccccc uucagaccca aggugaagag ccccuucgac     1980

ugcagcaacu ucgacaagga guuccugaac gagaagccca gacugagcuu cgccgacaga     2040

gcccugauca acagcaugga ccagaacaug uucagaaacu ucagcuucau gaaccccggc     2100

auggagagac ugaucagcug a                                               2121


<210>  8912
<211>  2121
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCT__Homo_sapiens__AAA60101

<400>  8912
augagccccu uccugagaau cggccucucc aacuuugacu gcgggucuug ucagagcugc       60

caaggagagg ccgugaaucc uuacugugcu guccugguua aggaauaugu ggaguccgaa      120

aacggccaga uguacauuca gaaaaagccg accauguauc ccccuuggga uucuacauuc      180

gacgcccaca ucaauaaagg gcgggugaug cagauuaucg ucaagggcaa aaacguggau      240

cuuauuagcg agacgaccgu ugaacuguac ucccucgcgg agcgcugcag aaagaauaac      300

ggaaagacag agaucuggcu ggaacuuaaa ccccaagggc ggaugcugau gaaugcucgc      360

uauuuucucg agaugucuga caccaaggau augaacgagu ucgaaacaga gggauuuuuc      420

gcccugcauc agagacgggg cgccaucaaa caggcuaagg ugcaccaugu caaaugucac      480

gaauuuaccg ccacauucuu uccucagccc accuucugca gcguguguca ugaguuuguu      540

uggggccuga auaagcaagg guaccagugc cgccagugua acgcugccau ucacaagaaa      600

ugcaucgaca aggugauugc gaaauguacg ggauccgcca ucaauagcag agaaaccaug      660

uuccacaagg agcgguuuaa aauugauaug ccucaucgcu ucaaggucua uaacuacaaa      720

ucuccgacau ucugcgaaca cugcggcacc cuccuguggg ggcuugcuag acagggacug      780

aagugugacg ccugcggcau gaaugugcau caccgguguc aaacaaaggu ggcuaaccuc      840

ugcgggauca aucagaaacu gauggccgag gcgcuugcca ugauugaguc cacccagcaa      900

gcucgcuguc ugagagauac ggaacagauc uuucgggagg gacccgucga aaucggccuc      960

ccuugcagca uuaagaacga ggccagaccc ccuugucugc ccacaccggg caaacgcgaa     1020

ccucagggga ucucuuggga gagcccccug gacgagguug auaagaugug ccaccucccu     1080

gaacccgagc ugaacaaaga acggcccucc cuucagauua agcugaagau cgaggacuuc     1140

auucuccaua aaaugcuggg aaagggcucu uuugggaaag uguuccuugc ugaauuuaag     1200

aaaaccaauc aauucuuugc caucaaggcc cugaagaaag augugguccu cauggacgac     1260

gauguggagu guacaauggu ugagaagaga gugcuguccc uggcuuggga acacccuuuc     1320

cucacccaua uguuuugcac cuuccagaca aaagagaacc uguuuuucgu cauggaauac     1380

cuuaauggag gcgaccugau guaucacauc cagagcuguc auaaguuuga ucucucccgc     1440

gcgacguucu acgccgcuga gauuauccug gggcuucagu uccugcacuc uaaaggaauu     1500

guguaucggg accucaagcu ggauaacauc cugcucgaca aggauggcca cauuaaaauc     1560

gccgacuuug gcaugugcaa ggagaauaug cugggggaug ccaaaaccaa cacauucugc     1620

ggaaccccgg acuacaucgc ucccgaaauu cuucugggcc aaaaguauaa ucauagcguu     1680

gauugguggu ccuuuggggu gcuccuguac gagaugcuga ucggacagag cccuuuccac     1740

ggccaggacg aagaggaacu uuuucauucu auuagaaugg acaaccccuu cuauccucgc     1800

uggcucgaga aagaggccaa ggaucugcug gucaaacucu uugugcggga acccgagaag     1860

agacuggggg uccgcggcga cauccggcag cacccgcuuu ucagagaaau uaauugggag     1920

gaacuggagc gcaaggagau cgauccuccc uuucggccua aagugaaguc ccccuucgac     1980

uguagcaacu uugauaaaga guuccucaau gaaaagccua gacugucuuu ugcggaccgc     2040

gcucugauua acagcaugga ucaaaauaug uuccggaacu ucuccuuuau gaaucccgga     2100

auggaaagac uuaucucuug a                                               2121


<210>  8913
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  KPCZ__Homo_sapiens__Q05513

<400>  8913

Met Pro Ser Arg Thr Gly Pro Lys Met Glu Gly Ser Gly Gly Arg Val 
1               5                   10                  15      


Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Phe Ile Thr Ser Val Asp 
            20                  25                  30          


Ala Ala Thr Thr Phe Glu Glu Leu Cys Glu Glu Val Arg Asp Met Cys 
        35                  40                  45              


Arg Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu 
    50                  55                  60                  


Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe 
65                  70                  75                  80  


Arg Leu Ala Arg Gln Cys Arg Asp Glu Gly Leu Ile Ile His Val Phe 
                85                  90                  95      


Pro Ser Thr Pro Glu Gln Pro Gly Leu Pro Cys Pro Gly Glu Asp Lys 
            100                 105                 110         


Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala 
        115                 120                 125             


Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys 
    130                 135                 140                 


Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg 
145                 150                 155                 160 


Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Gly Leu Val 
                165                 170                 175     


Pro Leu Thr Cys Arg Lys His Met Asp Ser Val Met Pro Ser Gln Glu 
            180                 185                 190         


Pro Pro Val Asp Asp Lys Asn Glu Asp Ala Asp Leu Pro Ser Glu Glu 
        195                 200                 205             


Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Ser Ile 
    210                 215                 220                 


Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Met Asp Gly 
225                 230                 235                 240 


Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg 
                245                 250                 255     


Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys 
            260                 265                 270         


Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val 
        275                 280                 285             


His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe 
    290                 295                 300                 


Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe 
305                 310                 315                 320 


Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly 
                325                 330                 335     


Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His 
            340                 345                 350         


Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His 
        355                 360                 365             


Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu 
    370                 375                 380                 


Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu 
385                 390                 395                 400 


Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn 
                405                 410                 415     


Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val 
            420                 425                 430         


Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg 
        435                 440                 445             


Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp 
    450                 455                 460                 


Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe 
465                 470                 475                 480 


Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp 
                485                 490                 495     


Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile 
            500                 505                 510         


Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys 
        515                 520                 525             


Lys Gln Ala Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly 
    530                 535                 540                 


Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr 
545                 550                 555                 560 


Pro Asp Asp Glu Asp Ala Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu 
                565                 570                 575     


Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Thr Glu Glu Ser Val 
            580                 585                 590         






<210>  8914
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  KPCZ__Homo_sapiens__AAH08058

<400>  8914
augcccagca ggaccggccc caagauggaa gggagcggcg gccgcguccg ccucaaggcg       60

cauuacgggg gggacaucuu caucaccagc guggacgccg ccacgaccuu cgaggagcuc      120

ugugaggaag ugagagacau gugucgucug caccagcagc acccgcucac ccucaagugg      180

guggacagcg aaggugaccc uugcacggug uccucccaga uggagcugga agaggcuuuc      240

cgccuggccc gucagugcag ggaugaaggc cucaucauuc auguuuuccc gagcaccccu      300

gagcagccug gccugccaug uccgggagaa gacaaaucua ucuaccgccg gggagccaga      360

agauggagga agcuguaccg ugccaacggc caccucuucc aagccaagcg cuuuaacagg      420

agagcguacu gcggucagug cagcgagagg auauggggcc ucgcgaggca aggcuacagg      480

ugcaucaacu gcaaacugcu gguccauaag cgcugccacg gccucguccc gcugaccugc      540

aggaagcaua uggauucugu caugccuucc caagagccuc caguagacga caagaacgag      600

gacgccgacc uuccuuccga ggagacagau ggaauugcuu acauuuccuc aucccggaag      660

caugacagca uuaaagacga cucggaggac cuuaagccag uuaucgaugg gauggaugga      720

aucaaaaucu cucaggggcu ugggcugcag gacuuugacc uaaucagagu caucgggcgc      780

gggagcuacg ccaagguucu ccuggugcgg uugaagaaga augaccaaau uuacgccaug      840

aaagugguga agaaagagcu ggugcaugau gacgaggaua uugacugggu acagacagag      900

aagcacgugu uugagcaggc auccagcaac cccuuccugg ucggauuaca cuccugcuuc      960

cagacgacaa gucgguuguu ccuggucauu gaguacguca acggcgggga ccugauguuc     1020

cacaugcaga ggcagaggaa gcucccugag gagcacgcca gguucuacgc ggccgagauc     1080

ugcaucgccc ucaacuuccu gcacgagagg gggaucaucu acagggaccu gaagcuggac     1140

aacguccucc uggaugcgga cgggcacauc aagcucacag acuacggcau gugcaaggaa     1200

ggccugggcc cuggugacac aacgagcacu uucugcggaa ccccgaauua caucgccccc     1260

gaaauccugc ggggagagga guacggguuc agcguggacu ggugggcgcu gggaguccuc     1320

auguuugaga ugauggccgg gcgcuccccg uucgacauca ucaccgacaa cccggacaug     1380

aacacagagg acuaccuuuu ccaagugauc cuggagaagc ccauccggau cccccgguuc     1440

cuguccguca aagccuccca uguuuuaaaa ggauuuuuaa auaaggaccc caaagagagg     1500

cucggcugcc ggccacagac uggauuuucu gacaucaagu cccacgcguu cuuccgcagc     1560

auagacuggg acuugcugga gaagaagcag gcgcucccuc cauuccagcc acagaucaca     1620

gacgacuacg gucuggacaa cuuugacaca caguucacca gcgagcccgu gcagcugacc     1680

ccagacgaug aggaugccau aaagaggauc gaccagucag aguucgaagg cuuugaguau     1740

aucaacccau uauugcuguc caccgaggag ucgguguga                            1779


<210>  8915
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       KPCZ__Homo_sapiens__AAH08058

<400>  8915
augcccagcc gcaccggccc gaagauggag ggguccggcg ggcgggugcg ccugaaggcc       60

cacuacggcg gggacaucuu caucaccagc gucgacgccg cgacgaccuu cgaggagcuc      120

ugcgaggagg ugcgggacau gugccgccug caccagcagc acccccugac ccucaagugg      180

guggacuccg agggcgaccc cugcaccguc agcucccaga uggagcugga ggaggccuuc      240

cggcuggccc gccagugccg ggacgagggc cucaucaucc acguguuccc cagcacgccg      300

gagcagcccg ggcugcccug ccccggcgag gacaagucca ucuaccgccg cggggcccgg      360

cgguggcgca agcuguaccg ggccaacggc caccucuucc aggcgaagcg cuucaaccgg      420

cgcgccuacu gcgggcagug cagcgagcgg aucuggggcc uggcccgcca gggcuaccgg      480

ugcaucaacu gcaagcugcu cgugcacaag cgcugccacg ggcugguccc gcugaccugc      540

cggaagcaca uggacuccgu gaugcccagc caggagccgc ccguggacga caagaacgag      600

gacgccgacc uccccuccga ggagaccgac ggcaucgcgu acaucagcuc cagccgcaag      660

cacgacucca ucaaggacga cagcgaggac cugaagcccg ucaucgacgg gauggacggc      720

aucaagaucu cccagggccu ggggcuccag gacuucgacc ugauccgcgu gaucggccgg      780

gggagcuacg ccaaggugcu gcucguccgc cugaagaaga acgaccagau cuacgccaug      840

aaggugguga agaaggagcu gguccacgac gacgaggaca ucgacugggu gcagaccgag      900

aagcacgugu ucgagcaggc cuccagcaac cccuuccucg ucggccugca cagcugcuuc      960

cagacgaccu cccggcuguu ccucgugauc gaguacguga acgggggcga ccugauguuc     1020

cacaugcagc gccagcggaa gcugcccgag gagcacgccc gcuucuacgc ggccgagauc     1080

ugcaucgccc ucaacuuccu gcacgagcgg ggcaucaucu accgcgaccu gaagcucgac     1140

aacguccugc uggacgccga cgggcacauc aagcucaccg acuacggcau gugcaaggag     1200

gggcugggcc cgggggacac cacgagcacc uucugcggca cccccaacua caucgccccc     1260

gagauccugc ggggcgagga guacggguuc uccguggacu ggugggcgcu cggcgugcug     1320

auguucgaga ugauggccgg gcgcagcccc uucgacauca ucaccgacaa cccggacaug     1380

aacacggagg acuaccuguu ccaggucauc cucgagaagc ccauccggau cccccgcuuc     1440

cuguccguga aggccagcca cguccugaag ggcuuccuca acaaggaccc caaggagcgg     1500

cuggggugcc gcccgcagac cggcuucucc gacaucaaga gccacgccuu cuuccggucc     1560

aucgacuggg accugcucga gaagaagcag gcccugccgc ccuuccagcc ccagaucacc     1620

gacgacuacg gccuggacaa cuucgacacc caguucacga gcgagcccgu gcagcugacc     1680

cccgacgacg aggacgcgau caagcgcauc gaccaguccg aguucgaggg guucgaguac     1740

aucaaccccc uccugcugag caccgaggag uccguguga                            1779


<210>  8916
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       KPCZ__Homo_sapiens__AAH08058

<400>  8916
augcccuccc gcaccggccc caagauggag ggcuccggcg gccgcguccg ccucaaggcc       60

cacuacggcg gcgacaucuu caucaccucc gucgacgccg ccaccaccuu cgaggagcuc      120

ugcgaggagg uccgcgacau gugccgccuc caccagcagc acccccucac ccucaagugg      180

gucgacuccg agggcgaccc cugcaccguc uccucccaga uggagcucga ggaggccuuc      240

cgccucgccc gccagugccg cgacgagggc cucaucaucc acgucuuccc cuccaccccc      300

gagcagcccg gccuccccug ccccggcgag gacaagucca ucuaccgccg cggcgcccgc      360

cgcuggcgca agcucuaccg cgccaacggc caccucuucc aggccaagcg cuucaaccgc      420

cgcgccuacu gcggccagug cuccgagcgc aucuggggcc ucgcccgcca gggcuaccgc      480

ugcaucaacu gcaagcuccu cguccacaag cgcugccacg gccucguccc ccucaccugc      540

cgcaagcaca uggacuccgu caugcccucc caggagcccc ccgucgacga caagaacgag      600

gacgccgacc uccccuccga ggagaccgac ggcaucgccu acaucuccuc cucccgcaag      660

cacgacucca ucaaggacga cuccgaggac cucaagcccg ucaucgacgg cauggacggc      720

aucaagaucu cccagggccu cggccuccag gacuucgacc ucauccgcgu caucggccgc      780

ggcuccuacg ccaagguccu ccucguccgc cucaagaaga acgaccagau cuacgccaug      840

aaggucguca agaaggagcu cguccacgac gacgaggaca ucgacugggu ccagaccgag      900

aagcacgucu ucgagcaggc cuccuccaac cccuuccucg ucggccucca cuccugcuuc      960

cagaccaccu cccgccucuu ccucgucauc gaguacguca acggcggcga ccucauguuc     1020

cacaugcagc gccagcgcaa gcuccccgag gagcacgccc gcuucuacgc cgccgagauc     1080

ugcaucgccc ucaacuuccu ccacgagcgc ggcaucaucu accgcgaccu caagcucgac     1140

aacguccucc ucgacgccga cggccacauc aagcucaccg acuacggcau gugcaaggag     1200

ggccucggcc ccggcgacac caccuccacc uucugcggca cccccaacua caucgccccc     1260

gagauccucc gcggcgagga guacggcuuc uccgucgacu ggugggcccu cggcguccuc     1320

auguucgaga ugauggccgg ccgcuccccc uucgacauca ucaccgacaa ccccgacaug     1380

aacaccgagg acuaccucuu ccaggucauc cucgagaagc ccauccgcau cccccgcuuc     1440

cucuccguca aggccuccca cguccucaag ggcuuccuca acaaggaccc caaggagcgc     1500

cucggcugcc gcccccagac cggcuucucc gacaucaagu cccacgccuu cuuccgcucc     1560

aucgacuggg accuccucga gaagaagcag gcccuccccc ccuuccagcc ccagaucacc     1620

gacgacuacg gccucgacaa cuucgacacc caguucaccu ccgagcccgu ccagcucacc     1680

cccgacgacg aggacgccau caagcgcauc gaccaguccg aguucgaggg cuucgaguac     1740

aucaaccccc uccuccucuc caccgaggag uccgucuga                            1779


<210>  8917
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       KPCZ__Homo_sapiens__AAH08058

<400>  8917
augcccagca gaaccggccc uaagauggag ggguccggag guagggugcg gcugaaagcc       60

cacuacggcg gggacaucuu cauuacaucu gucgaugcug caacuacguu ugaggaacuc      120

ugcgaagagg uucgcgacau gugucgacuu caucagcaac acccacugac cuugaagugg      180

guggauucag aaggagaccc gugcacagua aguagccaga uggaguuaga ggaagccuuc      240

cgucuggcga gacaguguag ggaugagggc cuaauaaucc auguguuucc cuccacuccu      300

gaacagccag gucuccccug cccuggggag gacaaaucua uuuaucggcg cggagcuaga      360

agguggcgga agcuguaccg cgccaacggc caccuuuucc aagcaaaacg auuuaauaga      420

agggccuauu guggccagug cucggagcgg aucugggggc uggcucguca gggauaccgc      480

uguauuaacu gcaaguugcu cguccauaag agaugucacg gucuggugcc acugaccugc      540

aggaaacaca uggauucagu uaugcccagc caggaaccuc caguggacga uaagaaugag      600

gacgcagauc ucccgaguga agagacagac ggcaucgccu auauauccuc uagccggaaa      660

caugauucca ucaaggacga cucagaagau uuaaaacccg ucauugacgg gauggaugga      720

aucaagauua gucaaggccu gggucuucag gacuucgauu ugauccgagu gauagggcgc      780

ggaagcuacg cuaagguacu gcuaguuaga cucaaaaaga acgaccagau uuaugccaug      840

aaagugguca agaaagagcu ggugcacgau gacgaggaua ucgacugggu gcagaccgaa      900

aagcaugucu uugagcaagc gucuuccaau ccuuuccuug uuggccugca cucauguuuu      960

cagacuacaa gcagguuguu ccucgugauu gaauacguaa acggcgggga ucugauguuu     1020

cacaugcagc ggcaacgcaa auuaccagag gaacaugcaa gauucuacgc cgcugagauc     1080

ugcaucgccc ugaauuuucu ccacgagagg ggaauuauau aucgugaccu uaagcuggac     1140

aacguguugc uagaugcaga cggucauauc aagcugaccg auuacggcau gugcaaagaa     1200

gggcucggac ccggcgacac gaccaguacu uucuguggua caccuaauua uauugcucca     1260

gagauccuga gaggggaaga guacggcuuc ucugucgauu ggugggcccu uggagugcug     1320

auguuugaaa ugauggcggg ccgauccccc uucgacauaa uuacugauaa cccggacaug     1380

aauaccgagg auuauuuguu ucagguuauc cucgagaagc cuauccggau ucccagguuc     1440

cugagcguga aagccucgca cgucuuaaag ggguuucuga acaaagaccc aaaggaacgc     1500

cuaggaugcc ggccucagac agguuucucu gauaucaagu cccaugcauu uuucagauca     1560

auugacuggg aucuccugga gaaaaagcag gcccuucccc cauuucaacc ccagauaacc     1620

gacgacuacg gcuuggauaa uuucgacacg caguuuacaa gugaaccugu gcagcugacu     1680

ccagaugacg aggaugcuau caaaaggauu gaccaaagcg aguucgaagg guuugaguau     1740

aucaacccgc uccugcuuuc caccgaagag ucuguauga                            1779


<210>  8918
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       KPCZ__Homo_sapiens__AAH08058

<400>  8918
augcccagca gaaccggccc caagauggag ggcagcggcg gcagagugag acugaaggcc       60

cacuacggcg gcgacaucuu caucaccagc guggacgccg ccaccaccuu cgaggagcug      120

ugcgaggagg ugagagacau gugcagacug caccagcagc acccccugac ccugaagugg      180

guggacagcg agggcgaccc cugcaccgug agcagccaga uggagcugga ggaggccuuc      240

agacuggcca gacagugcag agacgagggc cugaucaucc acguguuccc cagcaccccc      300

gagcagcccg gccugcccug ccccggcgag gacaagagca ucuacagaag aggcgccaga      360

agauggagaa agcuguacag agccaacggc caccuguucc aggccaagag auucaacaga      420

agagccuacu gcggccagug cagcgagaga aucuggggcc uggccagaca gggcuacaga      480

ugcaucaacu gcaagcugcu ggugcacaag agaugccacg gccuggugcc ccugaccugc      540

agaaagcaca uggacagcgu gaugcccagc caggagcccc ccguggacga caagaacgag      600

gacgccgacc ugcccagcga ggagaccgac ggcaucgccu acaucagcag cagcagaaag      660

cacgacagca ucaaggacga cagcgaggac cugaagcccg ugaucgacgg cauggacggc      720

aucaagauca gccagggccu gggccugcag gacuucgacc ugaucagagu gaucggcaga      780

ggcagcuacg ccaaggugcu gcuggugaga cugaagaaga acgaccagau cuacgccaug      840

aaggugguga agaaggagcu ggugcacgac gacgaggaca ucgacugggu gcagaccgag      900

aagcacgugu ucgagcaggc cagcagcaac cccuuccugg ugggccugca cagcugcuuc      960

cagaccacca gcagacuguu ccuggugauc gaguacguga acggcggcga ccugauguuc     1020

cacaugcaga gacagagaaa gcugcccgag gagcacgcca gauucuacgc cgccgagauc     1080

ugcaucgccc ugaacuuccu gcacgagaga ggcaucaucu acagagaccu gaagcuggac     1140

aacgugcugc uggacgccga cggccacauc aagcugaccg acuacggcau gugcaaggag     1200

ggccugggcc ccggcgacac caccagcacc uucugcggca cccccaacua caucgccccc     1260

gagauccuga gaggcgagga guacggcuuc agcguggacu ggugggcccu gggcgugcug     1320

auguucgaga ugauggccgg cagaagcccc uucgacauca ucaccgacaa ccccgacaug     1380

aacaccgagg acuaccuguu ccaggugauc cuggagaagc ccaucagaau ccccagauuc     1440

cugagcguga aggccagcca cgugcugaag ggcuuccuga acaaggaccc caaggagaga     1500

cugggcugca gaccccagac cggcuucagc gacaucaaga gccacgccuu cuucagaagc     1560

aucgacuggg accugcugga gaagaagcag gcccugcccc ccuuccagcc ccagaucacc     1620

gacgacuacg gccuggacaa cuucgacacc caguucacca gcgagcccgu gcagcugacc     1680

cccgacgacg aggacgccau caagagaauc gaccagagcg aguucgaggg cuucgaguac     1740

aucaaccccc ugcugcugag caccgaggag agcguguga                            1779


<210>  8919
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       KPCZ__Homo_sapiens__AAH08058

<400>  8919
augcccagca gaaccggccc uaagauggag ggguccggag gccgggugcg ccugaaagcc       60

cacuacgggg gagacaucuu cauuacaucu gucgaugcug ccacgaccuu ugaggaacuc      120

ugcgaagagg uuagagacau gugucggcug caucagcaac acccgcuuac acugaagugg      180

guggauagcg aaggcgaccc cugcaccgug uccucucaga uggagcucga ggaagcguuc      240

cgccuggcua gacagugucg ggaugagggg cuuaucauuc augucuuucc uagcacaccc      300

gaacagccug gacugcccug cccuggcgag gacaaaucca ucuaucgcag aggcgcccgg      360

cgcuggagaa agcucuaccg ggccaacggg caccuguucc aagcuaaacg cuuuaauaga      420

cgggccuauu guggacagug cucugagcgc auuuggggcc uggcuagaca gggguaccgg      480

uguaucaacu gcaagcuccu ggugcauaag agaugucacg gacuuguucc gcugaccugc      540

cgcaaacaca uggauagcgu gaugcccucc caggaaccuc ccgucgacga uaagaaugag      600

gacgccgauc ucccuagcga agagacagac ggcaucgcgu auauuucuuc cagccggaaa      660

caugauucua ucaaggacga cuccgaagau cugaaacccg ugauugacgg gauggaugga      720

aucaagauua gccaaggccu uggccugcag gacuucgauc ucaucagagu uauugggcgc      780

ggaucuuacg ccaaggugcu gcugguccgg cucaaaaaga acgaccagau cuaugcuaug      840

aaagugguga agaaagagcu gguccacgau gacgaggaua ucgacugggu ucagaccgaa      900

aagcaugugu uugagcaagc cuccagcaau ccguuccuug ugggccugca cuccuguuuu      960

cagacgaccu cuagacucuu ccuggucauu gaauacguga acgggggaga ucuuauguuu     1020

cacaugcagc gccaacggaa acugccugag gaacaugcua gauucuacgc cgcggagauc     1080

ugcauugccc ucaauuuucu gcacgagcgc ggcaucauuu aucgggaccu gaagcucgac     1140

aacguucugc uugaugcuga cgggcauauc aagcugacag auuacggaau gugcaaagaa     1200

ggccucggcc ccggggacac cacaagcacc uucuguggaa cgccuaauua uaucgccccc     1260

gagauucuga gaggcgaaga guacggguuc uccguggauu ggugggcucu uggaguccug     1320

auguuugaaa ugauggccgg ccgcagcccc uucgacauca uuacagauaa cccugacaug     1380

aauaccgagg auuaucucuu ucaggugauc cuggagaagc cgauucggau ccccagauuc     1440

cugucuguua aagccuccca cgugcucaag ggguuucuga acaaagaccc uaaggaacgg     1500

cuuggcugcc gcccccagac aggauucagc gauaucaagu cucaugcguu uuucagaagc     1560

auugacuggg aucugcucga gaaaaagcag gcucugccuc ccuuucaacc gcagaucacc     1620

gacgacuacg gccuggauaa uuucgacacc caguuuacau ccgaaccugu ccagcuuacg     1680

cccgaugacg aggaugccau uaaacggauc gaccaaucug aguucgaagg guuugaguau     1740

auuaacccuc uccugcugag caccgaagag uccguguga                            1779


<210>  8920
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LGP2__Homo_sapiens__A0A024R1Y5

<400>  8920

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


<210>  8921
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LGP2__Homo_sapiens__EAW60797

<400>  8921
auggagcuuc gguccuacca augggaggug aucaugccug cccuggaggg caagaauauc       60

aucaucuggc ugcccacggg ugccgggaag acccgggcgg cugcuuaugu ggccaagcgg      120

caccuagaga cuguggaugg agccaaggug guuguauugg ucaacagggu gcaccuggug      180

acccagcaug gugaagaguu caggcgcaug cuggauggac gcuggaccgu gacaacccug      240

aguggggaca ugggaccacg ugcuggcuuu ggccaccugg cccggugcca ugaccugcuc      300

aucugcacag cagagcuucu gcagauggca cugaccagcc ccgaggagga ggagcacgug      360

gagcucacug ucuucucccu gaucguggug gaugagugcc accacacgca caaggacacc      420

gucuacaacg ucaucaugag ccaguaccua gaacuuaaac uccagagggc acagccgcua      480

ccccaggugc ugggucucac agccucccca ggcacuggcg gggccuccaa acucgauggg      540

gccaucaacc acguccugca gcucugugcc aacuuggaca cguggugcau caugucaccc      600

cagaacugcu gcccccagcu gcaggagcac agccaacagc cuugcaaaca guacaaccuc      660

ugccacaggc gcagccagga uccguuuggg gacuugcuga agaagcucau ggaccaaauc      720

caugaccacc uggagaugcc ugaguugagc cggaaauuug ggacgcaaau guaugagcag      780

caggugguga agcugaguga ggcugcggcu uuggcugggc uucaggagca acggguguau      840

gcgcuucacc ugaggcgcua caaugacgcg cugcucaucc augacaccgu ccgcgccgug      900

gaugccuugg cugcgcugca ggauuucuau cacagggagc acgucacuaa aacccagauc      960

cugugugccg agcgccggcu gcuggcccug uucgaugacc gcaagaauga gcuggcccac     1020

uuggcaacuc auggcccaga gaauccaaaa cuggagaugc uggaaaagau ccugcaaagg     1080

caguucagua gcucuaacag cccucggggu aucaucuuca cccgcacccg ccaaagcgca     1140

cacucccucc ugcucuggcu ccagcagcag cagggccugc agacugugga cauccgggcc     1200

cagcuacuga uuggggcugg gaacagcagc cagagcaccc acaugaccca gagggaccag     1260

caagaaguga uccagaaguu ccaagaugga acccugaacc uucugguggc cacgagugug     1320

gcggaggagg ggcuggacau cccacauugc aauguggugg ugcguuaugg gcucuugacc     1380

aaugaaaucu ccauggucca ggccaggggc cgugcccggg ccgaucagag uguauacgcg     1440

uuuguagcaa cugaagguag ccgggagcug aagcgggagc ugaucaacga ggcgcuggag     1500

acgcugaugg agcaggcagu ggcugcugug cagaaaaugg accaggccga guaccaggcc     1560

aagauccggg aucugcagca ggcagccuug accaagcggg cggcccaggc agcccagcgg     1620

gagaaccagc ggcagcaguu cccaguggag cacgugcagc uacucugcau caacugcaug     1680

guggcugugg gccauggcag cgaccugcgg aagguggagg gcacccacca ugucaaugug     1740

aaccccaacu ucucgaacua cuauaauguc uccagggauc cuguggucau caacaaaguc     1800

uucaaggacu ggaagccugg gggugucauc agcugcagga acugugggga ggucuggggu     1860

cugcagauga ucuacaaguc agugaagcug ccagugcuca aaguccgcag caugcugcug     1920

gagaccccuc aggggcggau ccaggccaaa aagugguccc gcgugcccuu cuccgugccu     1980

gacuuugacu uccugcagca uugugccgag aacuugucgg accucucccu ggacuga        2037


<210>  8922
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LGP2__Homo_sapiens__EAW60797

<400>  8922
auggagcugc gcagcuacca gugggaggug aucaugcccg cccucgaggg caagaacauc       60

aucaucuggc ugccgaccgg ggccggcaag acccgggcgg ccgccuacgu cgccaagcgc      120

caccuggaga cgguggacgg ggccaaggug gucgugcucg ugaaccgggu ccaccuggug      180

acccagcacg gcgaggaguu ccgccggaug cuggacgggc gcuggaccgu gaccacgcuc      240

uccggcgaca ugggcccccg ggcgggguuc ggccaccugg cccgcugcca cgaccugcuc      300

aucugcaccg ccgagcugcu gcagauggcc cucaccagcc ccgaggagga ggagcacguc      360

gagcugaccg uguucucccu gaucgugguc gacgagugcc accacacgca caaggacacc      420

guguacaacg ugaucaugag ccaguaccuc gagcugaagc ugcagcgggc gcagccccuc      480

ccgcaggucc uggggcugac cgccuccccc ggcaccgggg gcgccagcaa gcucgacggc      540

gccaucaacc acgugcugca gcugugcgcc aaccucgaca cguggugcau caugagcccc      600

cagaacugcu gcccccagcu gcaggagcac ucccagcagc cgugcaagca guacaaccug      660

ugccaccgcc ggucccagga ccccuucggg gaccuccuga agaagcugau ggaccagauc      720

cacgaccacc ucgagaugcc cgagcugagc cgcaaguucg gcacccagau guacgagcag      780

caggucguga agcuguccga ggcggccgcc cucgccgggc ugcaggagca gcggguguac      840

gcccugcacc uccgccggua caacgacgcg cugcugaucc acgacaccgu gcgcgccguc      900

gacgcccucg ccgcccugca ggacuucuac caccgggagc acgugaccaa gacgcagauc      960

cugugcgcgg agcgccggcu ccuggcccug uucgacgacc gcaagaacga gcucgcccac     1020

cuggccaccc acggccccga gaacccgaag cuggagaugc ucgagaagau ccugcagcgg     1080

caguucagcu ccagcaacag cccccgcggc aucaucuuca cccgcacccg gcaguccgcc     1140

cacucccugc ugcucuggcu gcagcagcag caggggcugc agacggugga cauccgcgcg     1200

cagcuccuga ucggcgccgg gaacagcucc cagagcaccc acaugaccca gcgggaccag     1260

caggagguca uccagaaguu ccaggacggc acccugaacc uccugguggc cacgagcguc     1320

gccgaggagg ggcuggacau cccccacugc aacguggugg uccgcuacgg ccuccugacc     1380

aacgagaucu ccauggugca ggcgcggggc cgcgcccggg ccgaccagag cguguacgcc     1440

uucgucgcca ccgagggguc ccgcgagcug aagcgggagc ucaucaacga ggcgcuggag     1500

acccugaugg agcaggccgu ggccgccgug cagaagaugg accaggccga guaccaggcg     1560

aagauccgcg accuccagca ggccgcccug acgaagcggg ccgcccaggc ggcccagcgc     1620

gagaaccagc ggcagcaguu ccccgucgag cacgugcagc ugcucugcau caacugcaug     1680

guggccgucg gccacgggag cgaccugcgc aagguggagg gcacccacca cgugaacguc     1740

aacccgaacu ucuccaacua cuacaacgug agccgggacc ccguggucau caacaaggug     1800

uucaaggacu ggaagcccgg gggcgugauc uccugccgca acugcggcga ggucuggggg     1860

cugcagauga ucuacaagag cgugaagcuc cccgugcuga agguccgguc caugcugcuc     1920

gagaccccgc agggccgcau ccaggccaag aaguggagcc gggugcccuu cuccgugccc     1980

gacuucgacu uccugcagca cugcgcggag aaccugagcg accucucccu ggacuga        2037


<210>  8923
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LGP2__Homo_sapiens__EAW60797

<400>  8923
auggagcucc gcuccuacca gugggagguc aucaugcccg cccucgaggg caagaacauc       60

aucaucuggc uccccaccgg cgccggcaag acccgcgccg ccgccuacgu cgccaagcgc      120

caccucgaga ccgucgacgg cgccaagguc gucguccucg ucaaccgcgu ccaccucguc      180

acccagcacg gcgaggaguu ccgccgcaug cucgacggcc gcuggaccgu caccacccuc      240

uccggcgaca ugggcccccg cgccggcuuc ggccaccucg cccgcugcca cgaccuccuc      300

aucugcaccg ccgagcuccu ccagauggcc cucaccuccc ccgaggagga ggagcacguc      360

gagcucaccg ucuucucccu caucgucguc gacgagugcc accacaccca caaggacacc      420

gucuacaacg ucaucauguc ccaguaccuc gagcucaagc uccagcgcgc ccagccccuc      480

ccccaggucc ucggccucac cgccuccccc ggcaccggcg gcgccuccaa gcucgacggc      540

gccaucaacc acguccucca gcucugcgcc aaccucgaca ccuggugcau cauguccccc      600

cagaacugcu gcccccagcu ccaggagcac ucccagcagc ccugcaagca guacaaccuc      660

ugccaccgcc gcucccagga ccccuucggc gaccuccuca agaagcucau ggaccagauc      720

cacgaccacc ucgagaugcc cgagcucucc cgcaaguucg gcacccagau guacgagcag      780

caggucguca agcucuccga ggccgccgcc cucgccggcc uccaggagca gcgcgucuac      840

gcccuccacc uccgccgcua caacgacgcc cuccucaucc acgacaccgu ccgcgccguc      900

gacgcccucg ccgcccucca ggacuucuac caccgcgagc acgucaccaa gacccagauc      960

cucugcgccg agcgccgccu ccucgcccuc uucgacgacc gcaagaacga gcucgcccac     1020

cucgccaccc acggccccga gaaccccaag cucgagaugc ucgagaagau ccuccagcgc     1080

caguucuccu ccuccaacuc cccccgcggc aucaucuuca cccgcacccg ccaguccgcc     1140

cacucccucc uccucuggcu ccagcagcag cagggccucc agaccgucga cauccgcgcc     1200

cagcuccuca ucggcgccgg caacuccucc caguccaccc acaugaccca gcgcgaccag     1260

caggagguca uccagaaguu ccaggacggc acccucaacc uccucgucgc caccuccguc     1320

gccgaggagg gccucgacau cccccacugc aacgucgucg uccgcuacgg ccuccucacc     1380

aacgagaucu ccauggucca ggcccgcggc cgcgcccgcg ccgaccaguc cgucuacgcc     1440

uucgucgcca ccgagggcuc ccgcgagcuc aagcgcgagc ucaucaacga ggcccucgag     1500

acccucaugg agcaggccgu cgccgccguc cagaagaugg accaggccga guaccaggcc     1560

aagauccgcg accuccagca ggccgcccuc accaagcgcg ccgcccaggc cgcccagcgc     1620

gagaaccagc gccagcaguu ccccgucgag cacguccagc uccucugcau caacugcaug     1680

gucgccgucg gccacggcuc cgaccuccgc aaggucgagg gcacccacca cgucaacguc     1740

aaccccaacu ucuccaacua cuacaacguc ucccgcgacc ccgucgucau caacaagguc     1800

uucaaggacu ggaagcccgg cggcgucauc uccugccgca acugcggcga ggucuggggc     1860

cuccagauga ucuacaaguc cgucaagcuc cccguccuca agguccgcuc caugcuccuc     1920

gagacccccc agggccgcau ccaggccaag aagugguccc gcguccccuu cuccgucccc     1980

gacuucgacu uccuccagca cugcgccgag aaccucuccg accucucccu cgacuga        2037


<210>  8924
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LGP2__Homo_sapiens__EAW60797

<400>  8924
auggagcuga gaagcuacca gugggaagug aucaugcccg cccucgaggg caagaacauu       60

auaaucuggc uuccuaccgg ggcuggaaaa acaagggcag ccgcguaugu cgcuaagcgg      120

caccuggaaa cuguugacgg ugccaaagug guaguguugg ucaaucgcgu gcauuuaguu      180

acgcaacacg gcgaggaguu ccgacguaug cuggauggga gauggaccgu gacaacucua      240

uccggagaca ugggcccaag ggcagguuuu gggcaucucg cccggugcca cgaucugcuu      300

auuuguaccg cugaacuguu gcagauggca cucacaucuc cggaggaaga ggaacauguc      360

gagcugaccg uguucucacu gaucguaguu gacgagugcc accacacuca uaaggauaca      420

guguacaacg ucauuaugag ucaguaucuc gaauuaaaac ugcagcgcgc ccaaccccuu      480

ccucaggugu ugggacugac cgcuagccca ggcacgggcg gggccuccaa gcuagacgga      540

gcgaucaauc acgugcucca gcugugugca aaccuugaua cuuggugcau aaugucuccc      600

cagaauuguu gcccucaacu gcaggagcau ucgcagcagc cauguaagca auacaacuug      660

ugccacagaa ggucacagga ccccuuuggu gaucuccuga aaaaguuaau ggaccagauc      720

cacgaucauc uggaaaugcc ugagcucagc cggaaauucg gcacccaaau guaugaacag      780

caggucguua agcugaguga ggccgcugcc cuggcagggu ugcaggagca acgcguguac      840

gcucuacacc uucgaagaua uaaugacgcc cuccugauuc augauacagu aagggcggug      900

gacgcccuug cagcucugca ggacuuuuac caccgggaac augucacuaa aacccagauc      960

uugugugccg agcgucgccu ccuggcuuua uucgaugaca gaaagaacga acuggcccac     1020

cuagcaacac acggaccaga gaauccgaag cucgaaaugc uggagaaaau ucuucagagg     1080

caauuuuccu cuagcaacuc ccccagaggc aucauauuca cccgaacgcg ccagucagcc     1140

cauaguuugc ugcucuggcu gcagcagcaa cagggucuuc agacugugga uauuagagcu     1200

cagcuguuga ucggggcggg aaauagcucu caauccacac acaugaccca gagggaccag     1260

caagagguua uucagaaguu ucaggauggc acucucaacc uguuaguggc aacaucaguc     1320

gccgaagagg gccuggacau cccucauugc aaugugguag uucgguacgg gcuacucacc     1380

aacgaaauca gcauggugca ggcucgcgga cgggccaggg cagaucaaag ugucuaugcc     1440

uucguggcua cggaggguuc ucgugaacug aaacgggagc uuauuaauga ggccuuggaa     1500

acccugaugg agcaggcagu cgcggcugug cagaagaugg accaggccga auaccaagca     1560

aaaauacgag aucuccagca ggccgcucug acaaagagag ccgcacaggc ugcccaaagg     1620

gagaaccagc gccagcaauu uccaguugag cacgugcagu uacuguguau caacugcaug     1680

guagcggucg gccacggguc cgaccuucgg aaaguggaag gaacucauca cguuaaugug     1740

aaccccaauu ucagcaacua uuacaauguc ucgagagauc cugugguaau uaacaaggug     1800

uuuaaggacu ggaaaccagg cgguguuauc ucuugcagga auugugggga ggucuggggc     1860

uugcagauga uauauaaguc cgugaaacuc cccgugcuga agguccgcuc aaugcuacug     1920

gaaaccccgc agggacggau ucaagccaaa aaguggaguc gaguuccuuu cagcgugccc     1980

gacuucgauu uucuccagca uugcgcugag aaccuguccg accuuucuuu ggauuga        2037


<210>  8925
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LGP2__Homo_sapiens__EAW60797

<400>  8925
auggagcuga gaagcuacca gugggaggug aucaugcccg cccuggaggg caagaacauc       60

aucaucuggc ugcccaccgg cgccggcaag accagagccg ccgccuacgu ggccaagaga      120

caccuggaga ccguggacgg cgccaaggug guggugcugg ugaacagagu gcaccuggug      180

acccagcacg gcgaggaguu cagaagaaug cuggacggca gauggaccgu gaccacccug      240

agcggcgaca ugggccccag agccggcuuc ggccaccugg ccagaugcca cgaccugcug      300

aucugcaccg ccgagcugcu gcagauggcc cugaccagcc ccgaggagga ggagcacgug      360

gagcugaccg uguucagccu gaucguggug gacgagugcc accacaccca caaggacacc      420

guguacaacg ugaucaugag ccaguaccug gagcugaagc ugcagagagc ccagccccug      480

ccccaggugc ugggccugac cgccagcccc ggcaccggcg gcgccagcaa gcuggacggc      540

gccaucaacc acgugcugca gcugugcgcc aaccuggaca ccuggugcau caugagcccc      600

cagaacugcu gcccccagcu gcaggagcac agccagcagc ccugcaagca guacaaccug      660

ugccacagaa gaagccagga ccccuucggc gaccugcuga agaagcugau ggaccagauc      720

cacgaccacc uggagaugcc cgagcugagc agaaaguucg gcacccagau guacgagcag      780

caggugguga agcugagcga ggccgccgcc cuggccggcc ugcaggagca gagaguguac      840

gcccugcacc ugagaagaua caacgacgcc cugcugaucc acgacaccgu gagagccgug      900

gacgcccugg ccgcccugca ggacuucuac cacagagagc acgugaccaa gacccagauc      960

cugugcgccg agagaagacu gcuggcccug uucgacgaca gaaagaacga gcuggcccac     1020

cuggccaccc acggccccga gaaccccaag cuggagaugc uggagaagau ccugcagaga     1080

caguucagca gcagcaacag ccccagaggc aucaucuuca ccagaaccag acagagcgcc     1140

cacagccugc ugcuguggcu gcagcagcag cagggccugc agaccgugga caucagagcc     1200

cagcugcuga ucggcgccgg caacagcagc cagagcaccc acaugaccca gagagaccag     1260

caggagguga uccagaaguu ccaggacggc acccugaacc ugcugguggc caccagcgug     1320

gccgaggagg gccuggacau cccccacugc aacguggugg ugagauacgg ccugcugacc     1380

aacgagauca gcauggugca ggccagaggc agagccagag ccgaccagag cguguacgcc     1440

uucguggcca ccgagggcag cagagagcug aagagagagc ugaucaacga ggcccuggag     1500

acccugaugg agcaggccgu ggccgccgug cagaagaugg accaggccga guaccaggcc     1560

aagaucagag accugcagca ggccgcccug accaagagag ccgcccaggc cgcccagaga     1620

gagaaccaga gacagcaguu ccccguggag cacgugcagc ugcugugcau caacugcaug     1680

guggccgugg gccacggcag cgaccugaga aagguggagg gcacccacca cgugaacgug     1740

aaccccaacu ucagcaacua cuacaacgug agcagagacc ccguggugau caacaaggug     1800

uucaaggacu ggaagcccgg cggcgugauc agcugcagaa acugcggcga gguguggggc     1860

cugcagauga ucuacaagag cgugaagcug cccgugcuga aggugagaag caugcugcug     1920

gagacccccc agggcagaau ccaggccaag aaguggagca gagugcccuu cagcgugccc     1980

gacuucgacu uccugcagca cugcgccgag aaccugagcg accugagccu ggacuga        2037


<210>  8926
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LGP2__Homo_sapiens__EAW60797

<400>  8926
auggagcuga gaagcuacca gugggaagug aucaugcccg cccucgaggg caagaacauu       60

aucauuuggc ugccuaccgg ggcuggaaaa acacgggccg cggcuuaugu cgccaagcgc      120

caccuugaaa cgguugacgg cgccaaagug gugguccugg ugaauagagu ucaucucgug      180

acccaacacg gggaggaguu ccggcgcaug cuggauggaa gauggacagu caccacacuu      240

uccggcgaca uggggccgcg ggcuggauuu ggccaucugg cccgcugcca cgaucuccug      300

aucuguaccg cugaacugcu ccagauggcc cugacaucuc ccgaggaaga ggaacaugug      360

gagcuuaccg uuuucagccu gauugugguc gacgagugcc accacacgca uaaggauacc      420

guguacaacg ugaucauguc ccaguaucuc gaacugaaac uucagagagc gcaaccucug      480

ccccaggucc ucggccugac agccucuccu gggaccggag gcgcuagcaa gcuggacggg      540

gccaucaauc acguucucca gcugugugcu aaccuugaua cauggugcau uaugucuccc      600

cagaauuguu gcccucaacu gcaggagcau ucccagcagc cguguaagca auacaaccuc      660

ugccaccggc gcagccagga ccccuuugga gaucugcuua aaaagcugau ggaccagauc      720

cacgaucauc ucgaaaugcc ugagcugucc agaaaauucg gcacccaaau guaugaacaa      780

caggugguga agcugagcga ggccgcggcc cucgcugggc ugcaggagca gcgggucuac      840

gcccuucauc ugcgcagaua uaaugacgcu cuccugauuc acgauacggu gcgggccguu      900

gacgcccuug cugcgcugca ggacuuuuac caccgcgaac augugacaaa aacccagauc      960

cucugugccg agagacggcu gcuggcucuc uucgaugaca gaaagaacga acuggcccac     1020

cuugccacac acggacccga gaauccuaag cuggaaaugc ucgagaaaau ucugcagcgc     1080

caauuuucuu ccagcaacuc uccccggggc aucauuuuca ccagaacccg ccaguccgcu     1140

cauagccugc uucucuggcu gcagcagcaa cagggccugc agacagucga uauccgggcc     1200

cagcuccuga ucggggcggg aaauucuucc caaagcacgc acaugaccca gagagaccag     1260

caagagguga uucagaaguu ucaggauggc acacuuaacc ugcucguugc uaccuccgug     1320

gccgaagagg ggcuggacau cccgcauugc aaugucgugg uccgcuacgg acugcuuaca     1380

aacgaaauuu cuauggugca ggcccggggc agagcucgcg ccgaucaaag cguuuaugcu     1440

uucguggcca ccgagggguc ccgggaacuc aaaagagagc ugaucaauga ggcgcuggaa     1500

acgcucaugg agcaggccgu cgcugccgug cagaagaugg accaggcuga auaccaagcc     1560

aaaauucgcg aucugcagca ggcggcccuu acaaagcggg cugcccaggc ugcccaaaga     1620

gagaaccagc ggcagcaauu uccuguugag cacgugcagc ugcucuguau caacugcaug     1680

gucgccgugg gacacggcag cgaccugcgc aaaguggaag gcacccauca cguuaauguc     1740

aaccccaauu ucucuaacua uuacaaugug uccagagauc cuguggucau caacaaggug     1800

uuuaaggacu ggaaacccgg gggaguuauu agcugccgga auuguggcga gguguggggg     1860

cugcagauga ucuauaaguc ugucaaacuu cccgugcuca agguuagaag caugcugcug     1920

gaaaccccuc agggacgcau ucaagcuaaa aagugguccc gggugccguu cucugucccc     1980

gacuucgauu uucuccagca uugcgcggag aaccugagcg accuuucccu ggauuga        2037


<210>  8927
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LGP2__Homo_sapiens__Q96C10

<400>  8927

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


<210>  8928
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LGP2__Homo_sapiens__AAH14949

<400>  8928
auggagcuuc gguccuacca augggaggug aucaugccug cccuggaggg caagaauauc       60

aucaucuggc ugcccacggg ugccgggaag acccgggcgg cugcuuaugu ggccaagcgg      120

caccuagaga cuguggaugg agccaaggug guuguauugg ucaacagggu gcaccuggug      180

acccagcaug gugaagaguu caggcgcaug cuggauggac gcuggaccgu gacaacccug      240

aguggggaca ugggaccacg ugcuggcuuu ggccaccugg cccggugcca ugaccugcuc      300

aucugcacag cagagcuucu gcagauggca cugaccagcc ccgaggagga ggagcacgug      360

gagcucacug ucuucucccu gaucguggug gaugagugcc accacacgca caaggacacc      420

gucuacaacg ucaucaugag ccaguaccua gaacuuaaac uccagagggc acagccgcua      480

ccccaggugc ugggucucac agccucccca ggcacuggcg gggccuccaa acucgauggg      540

gccaucaacc acguccugca gcucugugcc aacuuggaca cguggugcau caugucaccc      600

cagaacugcu gcccccagcu gcaggagcac agccaacagc cuugcaaaca guacaaccuc      660

ugccacaggc gcagccagga uccguuuggg gacuugcuga agaagcucau ggaccaaauc      720

caugaccacc uggagaugcc ugaguugagc cggaaauuug ggacgcaaau guaugagcag      780

caggugguga agcugaguga ggcugcggcu uuggcugggc uucaggagca acggguguau      840

gcgcuucacc ugaggcgcua caaugacgcg cugcucaucc augacaccgu ccgcgccgug      900

gaugccuugg cugcgcugca ggauuucuau cacagggagc acgucacuaa aacccagauc      960

cugugugccg agcgccggcu gcuggcccug uucgaugacc gcaagaauga gcuggcccac     1020

uuggcaacuc auggcccaga gaauccaaaa cuggagaugc uggaaaagau ccugcaaagg     1080

caguucagua gcucuaacag cccucggggu aucaucuuca cccgcacccg ccaaagcgca     1140

cacucccucc ugcucuggcu ccagcagcag cagggccugc agacugugga cauccgggcc     1200

cagcuacuga uuggggcugg gaacagcagc cagagcaccc acaugaccca gagggaccag     1260

caagaaguga uccagaaguu ccaagaugga acccugaacc uucugguggc cacgagugug     1320

gcggaggagg ggcuggacau cccacauugc aauguggugg ugcguuaugg gcucuugacc     1380

aaugaaaucu ccauggucca ggccaggggc cgugcccggg ccgaucagag uguauacgcg     1440

uuuguagcaa cugaagguag ccgggagcug aagcgggagc ugaucaacga ggcgcuggag     1500

acgcugaugg agcaggcagu ggcugcugug cagaaaaugg accaggccga guaccaggcc     1560

aagauccggg aucugcagca ggcagccuug accaagcggg cggcccaggc agcccagcgg     1620

gagaaccagc ggcagcaguu cccaguggag cacgugcagc uacucugcau caacugcaug     1680

guggcugugg gccauggcag cgaccugcgg aagguggagg gcacccacca ugucaaugug     1740

aaccccaacu ucucgaacua cuauaauguc uccagggauc cuguggucau caacaaaguc     1800

uucaaggacu ggaagccugg gggugucauc agcugcagga acugugggga ggucuggggu     1860

cugcagauga ucuacaaguc agugaagcug ccagugcuca aaguccgcag caugcugcug     1920

gagaccccuc aggggcggau ccaggccaaa aagugguccc gcgugcccuu cuccgugccu     1980

gacuuugacu uccugcagca uugugccgag aacuugucgg accucucccu ggacuga        2037


<210>  8929
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LGP2__Homo_sapiens__AAH14949

<400>  8929
auggagcugc gcagcuacca gugggaggug aucaugcccg cccucgaggg caagaacauc       60

aucaucuggc ugccgaccgg ggccggcaag acccgggcgg ccgccuacgu cgccaagcgc      120

caccuggaga cgguggacgg ggccaaggug gucgugcucg ugaaccgggu ccaccuggug      180

acccagcacg gcgaggaguu ccgccggaug cuggacgggc gcuggaccgu gaccacgcuc      240

uccggcgaca ugggcccccg ggcgggguuc ggccaccugg cccgcugcca cgaccugcuc      300

aucugcaccg ccgagcugcu gcagauggcc cucaccagcc ccgaggagga ggagcacguc      360

gagcugaccg uguucucccu gaucgugguc gacgagugcc accacacgca caaggacacc      420

guguacaacg ugaucaugag ccaguaccuc gagcugaagc ugcagcgggc gcagccccuc      480

ccgcaggucc uggggcugac cgccuccccc ggcaccgggg gcgccagcaa gcucgacggc      540

gccaucaacc acgugcugca gcugugcgcc aaccucgaca cguggugcau caugagcccc      600

cagaacugcu gcccccagcu gcaggagcac ucccagcagc cgugcaagca guacaaccug      660

ugccaccgcc ggucccagga ccccuucggg gaccuccuga agaagcugau ggaccagauc      720

cacgaccacc ucgagaugcc cgagcugagc cgcaaguucg gcacccagau guacgagcag      780

caggucguga agcuguccga ggcggccgcc cucgccgggc ugcaggagca gcggguguac      840

gcccugcacc uccgccggua caacgacgcg cugcugaucc acgacaccgu gcgcgccguc      900

gacgcccucg ccgcccugca ggacuucuac caccgggagc acgugaccaa gacgcagauc      960

cugugcgcgg agcgccggcu ccuggcccug uucgacgacc gcaagaacga gcucgcccac     1020

cuggccaccc acggccccga gaacccgaag cuggagaugc ucgagaagau ccugcagcgg     1080

caguucagcu ccagcaacag cccccgcggc aucaucuuca cccgcacccg gcaguccgcc     1140

cacucccugc ugcucuggcu gcagcagcag caggggcugc agacggugga cauccgcgcg     1200

cagcuccuga ucggcgccgg gaacagcucc cagagcaccc acaugaccca gcgggaccag     1260

caggagguca uccagaaguu ccaggacggc acccugaacc uccugguggc cacgagcguc     1320

gccgaggagg ggcuggacau cccccacugc aacguggugg uccgcuacgg ccuccugacc     1380

aacgagaucu ccauggugca ggcgcggggc cgcgcccggg ccgaccagag cguguacgcc     1440

uucgucgcca ccgagggguc ccgcgagcug aagcgggagc ucaucaacga ggcgcuggag     1500

acccugaugg agcaggccgu ggccgccgug cagaagaugg accaggccga guaccaggcg     1560

aagauccgcg accuccagca ggccgcccug acgaagcggg ccgcccaggc ggcccagcgc     1620

gagaaccagc ggcagcaguu ccccgucgag cacgugcagc ugcucugcau caacugcaug     1680

guggccgucg gccacgggag cgaccugcgc aagguggagg gcacccacca cgugaacguc     1740

aacccgaacu ucuccaacua cuacaacgug agccgggacc ccguggucau caacaaggug     1800

uucaaggacu ggaagcccgg gggcgugauc uccugccgca acugcggcga ggucuggggg     1860

cugcagauga ucuacaagag cgugaagcuc cccgugcuga agguccgguc caugcugcuc     1920

gagaccccgc agggccgcau ccaggccaag aaguggagcc gggugcccuu cuccgugccc     1980

gacuucgacu uccugcagca cugcgcggag aaccugagcg accucucccu ggacuga        2037


<210>  8930
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LGP2__Homo_sapiens__AAH14949

<400>  8930
auggagcucc gcuccuacca gugggagguc aucaugcccg cccucgaggg caagaacauc       60

aucaucuggc uccccaccgg cgccggcaag acccgcgccg ccgccuacgu cgccaagcgc      120

caccucgaga ccgucgacgg cgccaagguc gucguccucg ucaaccgcgu ccaccucguc      180

acccagcacg gcgaggaguu ccgccgcaug cucgacggcc gcuggaccgu caccacccuc      240

uccggcgaca ugggcccccg cgccggcuuc ggccaccucg cccgcugcca cgaccuccuc      300

aucugcaccg ccgagcuccu ccagauggcc cucaccuccc ccgaggagga ggagcacguc      360

gagcucaccg ucuucucccu caucgucguc gacgagugcc accacaccca caaggacacc      420

gucuacaacg ucaucauguc ccaguaccuc gagcucaagc uccagcgcgc ccagccccuc      480

ccccaggucc ucggccucac cgccuccccc ggcaccggcg gcgccuccaa gcucgacggc      540

gccaucaacc acguccucca gcucugcgcc aaccucgaca ccuggugcau cauguccccc      600

cagaacugcu gcccccagcu ccaggagcac ucccagcagc ccugcaagca guacaaccuc      660

ugccaccgcc gcucccagga ccccuucggc gaccuccuca agaagcucau ggaccagauc      720

cacgaccacc ucgagaugcc cgagcucucc cgcaaguucg gcacccagau guacgagcag      780

caggucguca agcucuccga ggccgccgcc cucgccggcc uccaggagca gcgcgucuac      840

gcccuccacc uccgccgcua caacgacgcc cuccucaucc acgacaccgu ccgcgccguc      900

gacgcccucg ccgcccucca ggacuucuac caccgcgagc acgucaccaa gacccagauc      960

cucugcgccg agcgccgccu ccucgcccuc uucgacgacc gcaagaacga gcucgcccac     1020

cucgccaccc acggccccga gaaccccaag cucgagaugc ucgagaagau ccuccagcgc     1080

caguucuccu ccuccaacuc cccccgcggc aucaucuuca cccgcacccg ccaguccgcc     1140

cacucccucc uccucuggcu ccagcagcag cagggccucc agaccgucga cauccgcgcc     1200

cagcuccuca ucggcgccgg caacuccucc caguccaccc acaugaccca gcgcgaccag     1260

caggagguca uccagaaguu ccaggacggc acccucaacc uccucgucgc caccuccguc     1320

gccgaggagg gccucgacau cccccacugc aacgucgucg uccgcuacgg ccuccucacc     1380

aacgagaucu ccauggucca ggcccgcggc cgcgcccgcg ccgaccaguc cgucuacgcc     1440

uucgucgcca ccgagggcuc ccgcgagcuc aagcgcgagc ucaucaacga ggcccucgag     1500

acccucaugg agcaggccgu cgccgccguc cagaagaugg accaggccga guaccaggcc     1560

aagauccgcg accuccagca ggccgcccuc accaagcgcg ccgcccaggc cgcccagcgc     1620

gagaaccagc gccagcaguu ccccgucgag cacguccagc uccucugcau caacugcaug     1680

gucgccgucg gccacggcuc cgaccuccgc aaggucgagg gcacccacca cgucaacguc     1740

aaccccaacu ucuccaacua cuacaacguc ucccgcgacc ccgucgucau caacaagguc     1800

uucaaggacu ggaagcccgg cggcgucauc uccugccgca acugcggcga ggucuggggc     1860

cuccagauga ucuacaaguc cgucaagcuc cccguccuca agguccgcuc caugcuccuc     1920

gagacccccc agggccgcau ccaggccaag aagugguccc gcguccccuu cuccgucccc     1980

gacuucgacu uccuccagca cugcgccgag aaccucuccg accucucccu cgacuga        2037


<210>  8931
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LGP2__Homo_sapiens__AAH14949

<400>  8931
auggagcuga gaagcuacca gugggaagug aucaugcccg cccucgaggg caagaacauu       60

auaaucuggc uuccuaccgg ggcuggaaaa acaagggcag ccgcguaugu cgcuaagcgg      120

caccuggaaa cuguugacgg ugccaaagug guaguguugg ucaaucgcgu gcauuuaguu      180

acgcaacacg gcgaggaguu ccgacguaug cuggauggga gauggaccgu gacaacucua      240

uccggagaca ugggcccaag ggcagguuuu gggcaucucg cccggugcca cgaucugcuu      300

auuuguaccg cugaacuguu gcagauggca cucacaucuc cggaggaaga ggaacauguc      360

gagcugaccg uguucucacu gaucguaguu gacgagugcc accacacuca uaaggauaca      420

guguacaacg ucauuaugag ucaguaucuc gaauuaaaac ugcagcgcgc ccaaccccuu      480

ccucaggugu ugggacugac cgcuagccca ggcacgggcg gggccuccaa gcuagacgga      540

gcgaucaauc acgugcucca gcugugugca aaccuugaua cuuggugcau aaugucuccc      600

cagaauuguu gcccucaacu gcaggagcau ucgcagcagc cauguaagca auacaacuug      660

ugccacagaa ggucacagga ccccuuuggu gaucuccuga aaaaguuaau ggaccagauc      720

cacgaucauc uggaaaugcc ugagcucagc cggaaauucg gcacccaaau guaugaacag      780

caggucguua agcugaguga ggccgcugcc cuggcagggu ugcaggagca acgcguguac      840

gcucuacacc uucgaagaua uaaugacgcc cuccugauuc augauacagu aagggcggug      900

gacgcccuug cagcucugca ggacuuuuac caccgggaac augucacuaa aacccagauc      960

uugugugccg agcgucgccu ccuggcuuua uucgaugaca gaaagaacga acuggcccac     1020

cuagcaacac acggaccaga gaauccgaag cucgaaaugc uggagaaaau ucuucagagg     1080

caauuuuccu cuagcaacuc ccccagaggc aucauauuca cccgaacgcg ccagucagcc     1140

cauaguuugc ugcucuggcu gcagcagcaa cagggucuuc agacugugga uauuagagcu     1200

cagcuguuga ucggggcggg aaauagcucu caauccacac acaugaccca gagggaccag     1260

caagagguua uucagaaguu ucaggauggc acucucaacc uguuaguggc aacaucaguc     1320

gccgaagagg gccuggacau cccucauugc aaugugguag uucgguacgg gcuacucacc     1380

aacgaaauca gcauggugca ggcucgcgga cgggccaggg cagaucaaag ugucuaugcc     1440

uucguggcua cggaggguuc ucgugaacug aaacgggagc uuauuaauga ggccuuggaa     1500

acccugaugg agcaggcagu cgcggcugug cagaagaugg accaggccga auaccaagca     1560

aaaauacgag aucuccagca ggccgcucug acaaagagag ccgcacaggc ugcccaaagg     1620

gagaaccagc gccagcaauu uccaguugag cacgugcagu uacuguguau caacugcaug     1680

guagcggucg gccacggguc cgaccuucgg aaaguggaag gaacucauca cguuaaugug     1740

aaccccaauu ucagcaacua uuacaauguc ucgagagauc cugugguaau uaacaaggug     1800

uuuaaggacu ggaaaccagg cgguguuauc ucuugcagga auugugggga ggucuggggc     1860

uugcagauga uauauaaguc cgugaaacuc cccgugcuga agguccgcuc aaugcuacug     1920

gaaaccccgc agggacggau ucaagccaaa aaguggaguc gaguuccuuu cagcgugccc     1980

gacuucgauu uucuccagca uugcgcugag aaccuguccg accuuucuuu ggauuga        2037


<210>  8932
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LGP2__Homo_sapiens__AAH14949

<400>  8932
auggagcuga gaagcuacca gugggaggug aucaugcccg cccuggaggg caagaacauc       60

aucaucuggc ugcccaccgg cgccggcaag accagagccg ccgccuacgu ggccaagaga      120

caccuggaga ccguggacgg cgccaaggug guggugcugg ugaacagagu gcaccuggug      180

acccagcacg gcgaggaguu cagaagaaug cuggacggca gauggaccgu gaccacccug      240

agcggcgaca ugggccccag agccggcuuc ggccaccugg ccagaugcca cgaccugcug      300

aucugcaccg ccgagcugcu gcagauggcc cugaccagcc ccgaggagga ggagcacgug      360

gagcugaccg uguucagccu gaucguggug gacgagugcc accacaccca caaggacacc      420

guguacaacg ugaucaugag ccaguaccug gagcugaagc ugcagagagc ccagccccug      480

ccccaggugc ugggccugac cgccagcccc ggcaccggcg gcgccagcaa gcuggacggc      540

gccaucaacc acgugcugca gcugugcgcc aaccuggaca ccuggugcau caugagcccc      600

cagaacugcu gcccccagcu gcaggagcac agccagcagc ccugcaagca guacaaccug      660

ugccacagaa gaagccagga ccccuucggc gaccugcuga agaagcugau ggaccagauc      720

cacgaccacc uggagaugcc cgagcugagc agaaaguucg gcacccagau guacgagcag      780

caggugguga agcugagcga ggccgccgcc cuggccggcc ugcaggagca gagaguguac      840

gcccugcacc ugagaagaua caacgacgcc cugcugaucc acgacaccgu gagagccgug      900

gacgcccugg ccgcccugca ggacuucuac cacagagagc acgugaccaa gacccagauc      960

cugugcgccg agagaagacu gcuggcccug uucgacgaca gaaagaacga gcuggcccac     1020

cuggccaccc acggccccga gaaccccaag cuggagaugc uggagaagau ccugcagaga     1080

caguucagca gcagcaacag ccccagaggc aucaucuuca ccagaaccag acagagcgcc     1140

cacagccugc ugcuguggcu gcagcagcag cagggccugc agaccgugga caucagagcc     1200

cagcugcuga ucggcgccgg caacagcagc cagagcaccc acaugaccca gagagaccag     1260

caggagguga uccagaaguu ccaggacggc acccugaacc ugcugguggc caccagcgug     1320

gccgaggagg gccuggacau cccccacugc aacguggugg ugagauacgg ccugcugacc     1380

aacgagauca gcauggugca ggccagaggc agagccagag ccgaccagag cguguacgcc     1440

uucguggcca ccgagggcag cagagagcug aagagagagc ugaucaacga ggcccuggag     1500

acccugaugg agcaggccgu ggccgccgug cagaagaugg accaggccga guaccaggcc     1560

aagaucagag accugcagca ggccgcccug accaagagag ccgcccaggc cgcccagaga     1620

gagaaccaga gacagcaguu ccccguggag cacgugcagc ugcugugcau caacugcaug     1680

guggccgugg gccacggcag cgaccugaga aagguggagg gcacccacca cgugaacgug     1740

aaccccaacu ucagcaacua cuacaacgug agcagagacc ccguggugau caacaaggug     1800

uucaaggacu ggaagcccgg cggcgugauc agcugcagaa acugcggcga gguguggggc     1860

cugcagauga ucuacaagag cgugaagcug cccgugcuga aggugagaag caugcugcug     1920

gagacccccc agggcagaau ccaggccaag aaguggagca gagugcccuu cagcgugccc     1980

gacuucgacu uccugcagca cugcgccgag aaccugagcg accugagccu ggacuga        2037


<210>  8933
<211>  2037
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LGP2__Homo_sapiens__AAH14949

<400>  8933
auggagcuga gaagcuacca gugggaagug aucaugcccg cccucgaggg caagaacauu       60

aucauuuggc ugccuaccgg ggcuggaaaa acacgggccg cggcuuaugu cgccaagcgc      120

caccuugaaa cgguugacgg cgccaaagug gugguccugg ugaauagagu ucaucucgug      180

acccaacacg gggaggaguu ccggcgcaug cuggauggaa gauggacagu caccacacuu      240

uccggcgaca uggggccgcg ggcuggauuu ggccaucugg cccgcugcca cgaucuccug      300

aucuguaccg cugaacugcu ccagauggcc cugacaucuc ccgaggaaga ggaacaugug      360

gagcuuaccg uuuucagccu gauugugguc gacgagugcc accacacgca uaaggauacc      420

guguacaacg ugaucauguc ccaguaucuc gaacugaaac uucagagagc gcaaccucug      480

ccccaggucc ucggccugac agccucuccu gggaccggag gcgcuagcaa gcuggacggg      540

gccaucaauc acguucucca gcugugugcu aaccuugaua cauggugcau uaugucuccc      600

cagaauuguu gcccucaacu gcaggagcau ucccagcagc cguguaagca auacaaccuc      660

ugccaccggc gcagccagga ccccuuugga gaucugcuua aaaagcugau ggaccagauc      720

cacgaucauc ucgaaaugcc ugagcugucc agaaaauucg gcacccaaau guaugaacaa      780

caggugguga agcugagcga ggccgcggcc cucgcugggc ugcaggagca gcgggucuac      840

gcccuucauc ugcgcagaua uaaugacgcu cuccugauuc acgauacggu gcgggccguu      900

gacgcccuug cugcgcugca ggacuuuuac caccgcgaac augugacaaa aacccagauc      960

cucugugccg agagacggcu gcuggcucuc uucgaugaca gaaagaacga acuggcccac     1020

cuugccacac acggacccga gaauccuaag cuggaaaugc ucgagaaaau ucugcagcgc     1080

caauuuucuu ccagcaacuc uccccggggc aucauuuuca ccagaacccg ccaguccgcu     1140

cauagccugc uucucuggcu gcagcagcaa cagggccugc agacagucga uauccgggcc     1200

cagcuccuga ucggggcggg aaauucuucc caaagcacgc acaugaccca gagagaccag     1260

caagagguga uucagaaguu ucaggauggc acacuuaacc ugcucguugc uaccuccgug     1320

gccgaagagg ggcuggacau cccgcauugc aaugucgugg uccgcuacgg acugcuuaca     1380

aacgaaauuu cuauggugca ggcccggggc agagcucgcg ccgaucaaag cguuuaugcu     1440

uucguggcca ccgagggguc ccgggaacuc aaaagagagc ugaucaauga ggcgcuggaa     1500

acgcucaugg agcaggccgu cgcugccgug cagaagaugg accaggcuga auaccaagcc     1560

aaaauucgcg aucugcagca ggcggcccuu acaaagcggg cugcccaggc ugcccaaaga     1620

gagaaccagc ggcagcaauu uccuguugag cacgugcagc ugcucuguau caacugcaug     1680

gucgccgugg gacacggcag cgaccugcgc aaaguggaag gcacccauca cguuaauguc     1740

aaccccaauu ucucuaacua uuacaaugug uccagagauc cuguggucau caacaaggug     1800

uuuaaggacu ggaaacccgg gggaguuauu agcugccgga auuguggcga gguguggggg     1860

cugcagauga ucuauaaguc ugucaaacuu cccgugcuca agguuagaag caugcugcug     1920

gaaaccccuc agggacgcau ucaagcuaaa aagugguccc gggugccguu cucugucccc     1980

gacuucgauu uucuccagca uugcgcggag aaccugagcg accuuucccu ggauuga        2037


<210>  8934
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  l_IPAF__Homo_sapiens__Q9NPP4

<400>  8934

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala Arg Leu Val Gly Trp Gln Phe Asp 
        995                 1000                1005            


Asp Asp Asp Leu Ser Val Ile Thr Gly Ala Phe Lys Leu Val Thr Ala 
    1010                1015                1020                






<210>  8935
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  l_IPAF__Homo_sapiens__AAH31555

<400>  8935
augaauuuca uaaaggacaa uagccgagcc cuuauucaaa gaaugggaau gacuguuaua       60

aagcaaauca cagaugaccu auuuguaugg aauguucuga aucgcgaaga aguaaacauc      120

auuugcugcg agaaggugga gcaggaugcu gcuagaggga ucauucacau gauuuugaaa      180

aaggguucag aguccuguaa ccucuuucuu aaaucccuua aggaguggaa cuauccucua      240

uuucaggacu ugaauggaca aagucuuuuu caucagacau cagaaggaga cuuggacgau      300

uuggcucagg auuuaaagga cuuguaccau accccaucuu uucugaacuu uuauccccuu      360

ggugaagaua uugacauuau uuuuaacuug aaaagcaccu ucacagaacc uguccugugg      420

aggaaggacc aacaccauca ccgcguggag cagcugaccc ugaauggccu ccugcaggcu      480

cuucagagcc ccugcaucau ugaaggggaa ucuggcaaag gcaaguccac ucugcugcag      540

cgaauugcca ugcucugggg cuccggaaag ugcaaggcuc ugaccaaguu caaauucguc      600

uucuuccucc gucucagcag ggcccagggu ggacuuuuug aaacccucug ugaucaacuc      660

cuggauauac cuggcacaau caggaagcag acauucaugg ccaugcugcu gaagcugcgg      720

cagaggguuc uuuuccuucu ugauggcuac aaugaauuca agccccagaa cugcccagaa      780

aucgaagccc ugauaaagga aaaccaccgc uucaagaaca uggucaucgu caccacuacc      840

acugagugcc ugaggcacau acggcaguuu ggugcccuga cugcugaggu gggggauaug      900

acagaagaca gcgcccaggc ucucauccga gaagugcuga ucaaggagcu ugcugaaggc      960

uuguugcucc aaauucagaa auccaggugc uugaggaauc ucaugaagac cccucucuuu     1020

guggucauca cuugugcaau ccagaugggu gaaagugagu uccacucuca cacacaaaca     1080

acgcuguucc auaccuucua ugaucuguug auacagaaaa acaaacacaa acauaaaggu     1140

guggcugcaa gugacuucau ucggagccug gaccacugug gagaccuagc ucuggagggu     1200

guguucuccc acaaguuuga uuucgaacug caggaugugu ccagcgugaa ugaggauguc     1260

cugcugacaa cugggcuccu cuguaaauau acagcucaaa gguucaagcc aaaguauaaa     1320

uucuuucaca agucauucca ggaguacaca gcaggacgaa gacucagcag uuuauugacg     1380

ucucaugagc cagaggaggu gaccaagggg aaugguuacu ugcagaaaau gguuuccauu     1440

ucggacauua cauccacuua uagcagccug cuccgguaca ccuguggguc aucuguggaa     1500

gccaccaggg cuguuaugaa gcaccucgca gcaguguauc aacacggcug ccuucucgga     1560

cuuuccaucg ccaagaggcc ucucuggaga caggaaucuu ugcaaagugu gaaaaacacc     1620

acugagcaag aaauucugaa agccauaaac aucaauuccu uuguagagug uggcauccau     1680

uuauaucaag agaguacauc caaaucagcc cugagccaag aauuugaagc uuucuuucaa     1740

gguaaaagcu uauauaucaa cucagggaac auccccgauu acuuauuuga cuucuuugaa     1800

cauuugccca auugugcaag ugcccuggac uucauuaaac uggacuuuua ugggggagcu     1860

auggcuucau gggaaaaggc ugcagaagac acagguggaa uccacaugga agaggcccca     1920

gaaaccuaca uucccagcag ggcuguaucu uuguucuuca acuggaagca ggaauucagg     1980

acucuggagg ucacacuccg ggauuucagc aaguugaaua agcaagauau cagauaucug     2040

gggaaaauau ucagcucugc cacaagccuc aggcugcaaa uaaagagaug ugcuggugug     2100

gcuggaagcc ucaguuuggu ccucagcacc uguaagaaca uuuauucucu caugguggaa     2160

gccagucccc ucaccauaga agaugagagg cacaucacau cuguaacaaa ccugaaaacc     2220

uugaguauuc augaccuaca gaaucaacgg cugccgggug gucugacuga cagcuugggu     2280

aacuugaaga accuuacaaa gcucauaaug gauaacauaa agaugaauga agaagaugcu     2340

auaaaacuag cugaaggccu gaaaaaccug aagaagaugu guuuauuuca uuugacccac     2400

uugucugaca uuggagaggg aauggauuac auagucaagu cucugucaag ugaacccugu     2460

gaccuugaag aaauucaauu agucuccugc ugcuugucug caaaugcagu gaaaauccua     2520

gcucagaauc uucacaauuu ggucaaacug agcauucuug auuuaucaga aaauuaccug     2580

gaaaaagaug gaaaugaagc ucuucaugaa cugaucgaca ggaugaacgu gcuagaacag     2640

cucaccgcac ugaugcugcc cuggggcugu gacgugcaag gcagccugag cagccuguug     2700

aaacauuugg aggagguccc acaacucguc aagcuugggu ugaaaaacug gagacucaca     2760

gauacagaga uuagaauuuu aggugcauuu uuuggaaaga acccucugaa aaacuuccag     2820

caguugaauu uggcgggaaa ucgugugagc agugauggau ggcuugccuu caugggugua     2880

uuugagaauc uuaagcaauu aguguuuuuu gacuuuagua cuaaagaauu ucuaccugau     2940

ccagcauuag ucagaaaacu uagccaagug uuauccaagu uaacuuuucu gcaagaagcu     3000

aggcuuguug gguggcaauu ugaugaugau gaucucagug uuauuacagg ugcuuuuaaa     3060

cuaguaacug cuuaa                                                      3075


<210>  8936
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       l_IPAF__Homo_sapiens__AAH31555

<400>  8936
augaacuuca ucaaggacaa cagccgcgcc cugauccagc ggaugggcau gaccgugauc       60

aagcagauca ccgacgaccu cuucgucugg aacgugcuga accgcgagga ggugaacauc      120

aucugcugcg agaaggucga gcaggacgcc gcgcggggga ucauccacau gauccugaag      180

aagggcuccg agagcugcaa ccucuuccug aagucccuga aggaguggaa cuacccccuc      240

uuccaggacc ugaacgggca gagccuguuc caccagacgu ccgagggcga ccucgacgac      300

cuggcccagg accugaagga ccucuaccac accccgagcu uccugaacuu cuacccccug      360

ggggaggaca ucgacaucau cuucaaccuc aaguccaccu ucaccgagcc cgugcugugg      420

cgcaaggacc agcaccacca ccggguggag cagcugacgc ucaacggccu gcugcaggcc      480

cuccagagcc ccugcaucau cgagggcgag uccgggaagg gcaagagcac ccugcugcag      540

cgcaucgcca ugcucugggg guccggcaag ugcaaggccc ugaccaaguu caaguucguc      600

uucuuccugc ggcucagccg cgcgcagggc gggcuguucg agacccugug cgaccagcuc      660

cuggacaucc cgggcacgau ccggaagcag accuucaugg ccaugcugcu caagcugcgc      720

cagcgggugc uguuccuccu ggacggguac aacgaguuca agccccagaa cugccccgag      780

aucgaggccc ugaucaagga gaaccaccgc uucaagaaca uggugaucgu caccaccacg      840

accgagugcc uccggcacau ccgccaguuc ggcgcccuga ccgcggaggu gggggacaug      900

accgaggacu ccgcccaggc ccugauccgg gaggugcuca ucaaggagcu ggccgagggc      960

cugcuccugc agauccagaa gucccgcugc cugcggaacc ucaugaagac gccccuguuc     1020

gucgugauca cgugcgccau ccagaugggc gaguccgagu uccacagcca cacccagacc     1080

acccuguucc acaccuucua cgaccugcuc auccagaaga acaagcacaa gcacaagggg     1140

guggcggccu ccgacuucau ccgcagccug gaccacugcg gcgaccuggc ccucgagggg     1200

gucuucuccc acaaguucga cuucgagcug caggacguga gcagcgugaa cgaggacguc     1260

cugcucacca ccggccugcu gugcaaguac acggcccagc gguucaagcc gaaguacaag     1320

uucuuccaca aguccuucca ggaguacacc gccgggcgcc ggcucagcuc ccugcugacc     1380

agccacgagc ccgaggaggu gaccaagggc aacggcuacc uccagaagau gguguccauc     1440

agcgacauca cguccaccua cagcucccug cugcgcuaca cgugcgggag cuccgucgag     1500

gcgacccgcg ccgugaugaa gcaccucgcc gccguguacc agcacggcug ccugcugggg     1560

cucagcaucg ccaagcggcc ccuguggcgc caggaguccc ugcagagcgu caagaacacc     1620

accgagcagg agauccucaa ggcgaucaac aucaacuccu ucguggagug cggcauccac     1680

cuguaccagg agagcaccuc caagagcgcc cugucccagg aguucgaggc cuucuuccag     1740

ggcaagagcc ucuacaucaa cagcgggaac auccccgacu accuguucga cuucuucgag     1800

caccucccga acugcgccuc cgcccuggac uucaucaagc uggacuucua cggcggggcg     1860

auggccagcu gggagaaggc cgccgaggac accggcggga uccacaugga ggaggcgccc     1920

gagacguaca uccccucccg ggccgucagc cuguucuuca acuggaagca ggaguuccgc     1980

acccucgagg ugacccugcg ggacuucucc aagcugaaca agcaggacau ccgcuaccuc     2040

ggcaagaucu ucagcuccgc caccagccug cggcugcaga ucaagcgcug cgccggggug     2100

gccggcuccc ucagccuggu ccuguccacg ugcaagaaca ucuacagccu caugguggag     2160

gcgagccccc ugaccaucga ggacgagcgg cacaucacca gcgugaccaa ccugaagacc     2220

cucuccaucc acgaccugca gaaccagcgc cugccgggcg ggcucacgga cagccugggc     2280

aaccugaaga accucaccaa gcugaucaug gacaacauca agaugaacga ggaggacgcc     2340

aucaagcugg ccgaggggcu caagaaccug aagaagaugu gccuguucca ccucacccac     2400

cuguccgaca ucggcgaggg cauggacuac aucgucaaga gccugagcuc cgagcccugc     2460

gaccucgagg agauccagcu ggugagcugc ugccuguccg ccaacgccgu gaagauccuc     2520

gcgcagaacc ugcacaaccu ggucaagcuc agcauccugg accuguccga gaacuaccuc     2580

gagaaggacg ggaacgaggc ccugcacgag cugaucgacc ggaugaacgu gcucgagcag     2640

cugaccgccc ugaugcuccc cuggggcugc gacgugcagg ggagccuguc cagccugcuc     2700

aagcaccugg aggagguccc ccagcuggug aagcucggcc ugaagaacug gcgccugacg     2760

gacaccgaga uccggauccu cggggccuuc uucggcaaga acccgcugaa gaacuuccag     2820

cagcugaacc ucgccggcaa ccgcgugucc agcgacgggu ggcuggcguu caugggcguc     2880

uucgagaacc ugaagcagcu cguguucuuc gacuucucca ccaaggaguu ccugcccgac     2940

cccgcccugg ugcggaagcu cagccagguc cuguccaagc ugaccuuccu ccaggaggcc     3000

cgccuggugg gguggcaguu cgacgacgac gaccugagcg ugaucacggg cgccuucaag     3060

cuggucaccg cguga                                                      3075


<210>  8937
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       l_IPAF__Homo_sapiens__AAH31555

<400>  8937
augaacuuca ucaaggacaa cucccgcgcc cucauccagc gcaugggcau gaccgucauc       60

aagcagauca ccgacgaccu cuucgucugg aacguccuca accgcgagga ggucaacauc      120

aucugcugcg agaaggucga gcaggacgcc gcccgcggca ucauccacau gauccucaag      180

aagggcuccg aguccugcaa ccucuuccuc aagucccuca aggaguggaa cuacccccuc      240

uuccaggacc ucaacggcca gucccucuuc caccagaccu ccgagggcga ccucgacgac      300

cucgcccagg accucaagga ccucuaccac acccccuccu uccucaacuu cuacccccuc      360

ggcgaggaca ucgacaucau cuucaaccuc aaguccaccu ucaccgagcc cguccucugg      420

cgcaaggacc agcaccacca ccgcgucgag cagcucaccc ucaacggccu ccuccaggcc      480

cuccaguccc ccugcaucau cgagggcgag uccggcaagg gcaaguccac ccuccuccag      540

cgcaucgcca ugcucugggg cuccggcaag ugcaaggccc ucaccaaguu caaguucguc      600

uucuuccucc gccucucccg cgcccagggc ggccucuucg agacccucug cgaccagcuc      660

cucgacaucc ccggcaccau ccgcaagcag accuucaugg ccaugcuccu caagcuccgc      720

cagcgcgucc ucuuccuccu cgacggcuac aacgaguuca agccccagaa cugccccgag      780

aucgaggccc ucaucaagga gaaccaccgc uucaagaaca uggucaucgu caccaccacc      840

accgagugcc uccgccacau ccgccaguuc ggcgcccuca ccgccgaggu cggcgacaug      900

accgaggacu ccgcccaggc ccucauccgc gagguccuca ucaaggagcu cgccgagggc      960

cuccuccucc agauccagaa gucccgcugc cuccgcaacc ucaugaagac cccccucuuc     1020

gucgucauca ccugcgccau ccagaugggc gaguccgagu uccacuccca cacccagacc     1080

acccucuucc acaccuucua cgaccuccuc auccagaaga acaagcacaa gcacaagggc     1140

gucgccgccu ccgacuucau ccgcucccuc gaccacugcg gcgaccucgc ccucgagggc     1200

gucuucuccc acaaguucga cuucgagcuc caggacgucu ccuccgucaa cgaggacguc     1260

cuccucacca ccggccuccu cugcaaguac accgcccagc gcuucaagcc caaguacaag     1320

uucuuccaca aguccuucca ggaguacacc gccggccgcc gccucuccuc ccuccucacc     1380

ucccacgagc ccgaggaggu caccaagggc aacggcuacc uccagaagau ggucuccauc     1440

uccgacauca ccuccaccua cuccucccuc cuccgcuaca ccugcggcuc cuccgucgag     1500

gccacccgcg ccgucaugaa gcaccucgcc gccgucuacc agcacggcug ccuccucggc     1560

cucuccaucg ccaagcgccc ccucuggcgc caggaguccc uccaguccgu caagaacacc     1620

accgagcagg agauccucaa ggccaucaac aucaacuccu ucgucgagug cggcauccac     1680

cucuaccagg aguccaccuc caaguccgcc cucucccagg aguucgaggc cuucuuccag     1740

ggcaaguccc ucuacaucaa cuccggcaac auccccgacu accucuucga cuucuucgag     1800

caccucccca acugcgccuc cgcccucgac uucaucaagc ucgacuucua cggcggcgcc     1860

auggccuccu gggagaaggc cgccgaggac accggcggca uccacaugga ggaggccccc     1920

gagaccuaca uccccucccg cgccgucucc cucuucuuca acuggaagca ggaguuccgc     1980

acccucgagg ucacccuccg cgacuucucc aagcucaaca agcaggacau ccgcuaccuc     2040

ggcaagaucu ucuccuccgc caccucccuc cgccuccaga ucaagcgcug cgccggcguc     2100

gccggcuccc ucucccucgu ccucuccacc ugcaagaaca ucuacucccu cauggucgag     2160

gccucccccc ucaccaucga ggacgagcgc cacaucaccu ccgucaccaa ccucaagacc     2220

cucuccaucc acgaccucca gaaccagcgc cuccccggcg gccucaccga cucccucggc     2280

aaccucaaga accucaccaa gcucaucaug gacaacauca agaugaacga ggaggacgcc     2340

aucaagcucg ccgagggccu caagaaccuc aagaagaugu gccucuucca ccucacccac     2400

cucuccgaca ucggcgaggg cauggacuac aucgucaagu cccucuccuc cgagcccugc     2460

gaccucgagg agauccagcu cgucuccugc ugccucuccg ccaacgccgu caagauccuc     2520

gcccagaacc uccacaaccu cgucaagcuc uccauccucg accucuccga gaacuaccuc     2580

gagaaggacg gcaacgaggc ccuccacgag cucaucgacc gcaugaacgu ccucgagcag     2640

cucaccgccc ucaugcuccc cuggggcugc gacguccagg gcucccucuc cucccuccuc     2700

aagcaccucg aggagguccc ccagcucguc aagcucggcc ucaagaacug gcgccucacc     2760

gacaccgaga uccgcauccu cggcgccuuc uucggcaaga acccccucaa gaacuuccag     2820

cagcucaacc ucgccggcaa ccgcgucucc uccgacggcu ggcucgccuu caugggcguc     2880

uucgagaacc ucaagcagcu cgucuucuuc gacuucucca ccaaggaguu ccuccccgac     2940

cccgcccucg uccgcaagcu cucccagguc cucuccaagc ucaccuuccu ccaggaggcc     3000

cgccucgucg gcuggcaguu cgacgacgac gaccucuccg ucaucaccgg cgccuucaag     3060

cucgucaccg ccuga                                                      3075


<210>  8938
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       l_IPAF__Homo_sapiens__AAH31555

<400>  8938
augaacuuca ucaaggacaa uagcagagcc cugauucaga ggaugggcau gaccgugaua       60

aaacaaauca cagaugaccu cuuugucugg aacguucuua aucgggagga agugaacauu      120

aucugcugug agaagguaga acaggaugcu gcacgcggga uuauccacau gauacugaaa      180

aagggauccg agucuugcaa uuuguucuua aaaucacuga aggaauggaa cuacccccua      240

uuucaggacc ucaaugguca gagucuguuc caucaaacua gcgagggcga ucuugacgau      300

cuggcccagg acuugaagga ucucuaucac acgccuuccu uucugaacuu cuacccacug      360

ggggaggaca ucgauauuau cuuuaaucuc aaaucuaccu ucacagaacc gguguuaugg      420

cgaaaggacc agcaucacca ucgugucgag cagcugacuc uuaacggauu gcugcaagcg      480

cuacagucgc ccuguauuau cgaaggcgag ucagguaaag gaaagagcac ccuccugcag      540

agaauagcua ugcuuugggg aaguggcaaa ugcaaggccc ugacaaaguu uaaauucgug      600

uuuuucuuga ggcucucccg ggcacagggc gggcuguuug agaccuuaug ugaucaacug      660

cucgacauuc cuggaacuau ccgcaagcag acauucaugg ccaugcuucu gaaauugaga      720

cagaggguuc uauuccugcu cgacgguuau aaugaauuua agccacaaaa cugccccgag      780

auugaagcuc ugaucaaaga gaaucaccgg uucaagaaca uggugaucgu caccacgacu      840

accgaauguc uucgccacau ucgacaguuu ggcgcacuga cagccgaggu gggggauaug      900

acugaggacu cugcucaggc cuugauaaga gaaguacuca ucaaagagcu ggcggaagga      960

uuacugcuac agauucaaaa guccaggugc cuccggaauc ugaugaagac cccucuuuuc     1020

guugugauca caugugcaau acagaugggc gagagcgaau uucauucaca cacccagacg     1080

acuuuguucc auacauuuua cgaucugcuc auucagaaaa acaagcacaa acacaagggu     1140

gucgccgcua gugacuucau ccguagccug gaucauugcg gggaccuugc ccuggaggga     1200

guguuuucuc acaaauucga uuuugaguug caagacgugu ccucagucaa cgaagauguu     1260

cuccugacca cuggcuuacu guguaaguau acagcacagc gcuucaagcc aaaauacaag     1320

uuuuuccaua agagcuucca ggaguauacc gcuggcagaa ggcuaaguuc ucuccugacg     1380

ucccacgaac ccgaggaagu gaccaaaggg aauggauacc uucagaaaau gguaagcauc     1440

ucggacauua caucuacuua cuccucauug cugcgguaua ccugcgguag uagcguggag     1500

gccacacgag cggucaugaa gcaucucgcc gcaguguacc aacacggcug ccuguuaggg     1560

cuguccaucg cuaagcgccc ucuuuggaga caggagucuu ugcagagcgu uaaaaacacu     1620

accgaacagg agauucucaa ggccauaaau aucaacucau uuguggaaug ugggauucac     1680

cuguaucaag agaguacauc caaaagcgcu cuaucucagg aguucgaagc cuuuuuccag     1740

ggcaagucac uguacaucaa uagugguaac aucccagauu aucucuuuga cuucuuugag     1800

caucugccga auugcgcaag cgcccuugac uucauuaaau uggauuuuua cgggggcgcu     1860

auggcguccu gggaaaaggc agccgaggac accggaggca uacacaugga agaggcuccc     1920

gagacuuaua ucccuucuag ggccgucucg cuguucuuua acuggaagca agaguuccgg     1980

acguuagaag ugacacuccg cgauuuuagc aaacugaaua agcaggacau uagauaccuu     2040

gggaaaaucu ucuccucagc aaccagucug agguugcaga uuaagcguug ugccggagua     2100

gcugguucuc ucagccuggu ucuauccacu ugcaaaaaca ucuacucacu gaugguggaa     2160

gccagcccac ucaccauaga ggaugaacgg cauaucacau cugucaccaa ucugaagacu     2220

cuuuccauuc acgacuugca gaaccaacga cugcccggcg gguuaacaga uagucucgga     2280

aaucugaaaa accuuacgaa gcugaucaug gacaauauua agaugaacga ggaggaugca     2340

aucaaacuag cggaaggccu caagaaccug aaaaagaugu guuuguucca ccugacccau     2400

uuaagcgaca uaggugaggg gauggauuau auugugaaau cucucuccuc agaaccuugc     2460

gaccuggagg aaauccagcu ugucaguugu ugccugagcg cuaaugccgu gaagauuuug     2520

gcacagaacc uccacaaucu gguuaagcua ucgauccugg aucuuuccga gaacuaccuc     2580

gagaaagacg gcaaugaagc ccugcaugag uugauagaca gaaugaacgu gcuggaacag     2640

uuaacugcuc ucaugcugcc auggggaugu gauguacaag gcucucuuag cucacuguug     2700

aagcaccucg aggagguccc ccagcuggug aaacuagggc ugaagaauug gaggcuuaca     2760

gacaccgaaa uccgcauucu cggagccuuu uucgguaaaa acccgcugaa gaauuuucag     2820

caguugaacu uagcaggcaa ucggguuagu uccgaugggu ggcuggcuuu caugggagug     2880

uuugagaacc ucaagcaacu ggucuucuuu gacuucucua caaaagaauu ucuuccugau     2940

cccgcccugg ugagaaaguu gagccaggua cuauccaaac ugacuuuccu ccaggaggcg     3000

aggcuggugg gcuggcaauu ugacgaugac gaucuuucag uuaucaccgg ugccuucaag     3060

uuagucacgg cuuga                                                      3075


<210>  8939
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       l_IPAF__Homo_sapiens__AAH31555

<400>  8939
augaacuuca ucaaggacaa cagcagagcc cugauccaga gaaugggcau gaccgugauc       60

aagcagauca ccgacgaccu guucgugugg aacgugcuga acagagagga ggugaacauc      120

aucugcugcg agaaggugga gcaggacgcc gccagaggca ucauccacau gauccugaag      180

aagggcagcg agagcugcaa ccuguuccug aagagccuga aggaguggaa cuacccccug      240

uuccaggacc ugaacggcca gagccuguuc caccagacca gcgagggcga ccuggacgac      300

cuggcccagg accugaagga ccuguaccac acccccagcu uccugaacuu cuacccccug      360

ggcgaggaca ucgacaucau cuucaaccug aagagcaccu ucaccgagcc cgugcugugg      420

agaaaggacc agcaccacca cagaguggag cagcugaccc ugaacggccu gcugcaggcc      480

cugcagagcc ccugcaucau cgagggcgag agcggcaagg gcaagagcac ccugcugcag      540

agaaucgcca ugcugugggg cagcggcaag ugcaaggccc ugaccaaguu caaguucgug      600

uucuuccuga gacugagcag agcccagggc ggccuguucg agacccugug cgaccagcug      660

cuggacaucc ccggcaccau cagaaagcag accuucaugg ccaugcugcu gaagcugaga      720

cagagagugc uguuccugcu ggacggcuac aacgaguuca agccccagaa cugccccgag      780

aucgaggccc ugaucaagga gaaccacaga uucaagaaca uggugaucgu gaccaccacc      840

accgagugcc ugagacacau cagacaguuc ggcgcccuga ccgccgaggu gggcgacaug      900

accgaggaca gcgcccaggc ccugaucaga gaggugcuga ucaaggagcu ggccgagggc      960

cugcugcugc agauccagaa gagcagaugc cugagaaacc ugaugaagac cccccuguuc     1020

guggugauca ccugcgccau ccagaugggc gagagcgagu uccacagcca cacccagacc     1080

acccuguucc acaccuucua cgaccugcug auccagaaga acaagcacaa gcacaagggc     1140

guggccgcca gcgacuucau cagaagccug gaccacugcg gcgaccuggc ccuggagggc     1200

guguucagcc acaaguucga cuucgagcug caggacguga gcagcgugaa cgaggacgug     1260

cugcugacca ccggccugcu gugcaaguac accgcccaga gauucaagcc caaguacaag     1320

uucuuccaca agagcuucca ggaguacacc gccggcagaa gacugagcag ccugcugacc     1380

agccacgagc ccgaggaggu gaccaagggc aacggcuacc ugcagaagau ggugagcauc     1440

agcgacauca ccagcaccua cagcagccug cugagauaca ccugcggcag cagcguggag     1500

gccaccagag ccgugaugaa gcaccuggcc gccguguacc agcacggcug ccugcugggc     1560

cugagcaucg ccaagagacc ccuguggaga caggagagcc ugcagagcgu gaagaacacc     1620

accgagcagg agauccugaa ggccaucaac aucaacagcu ucguggagug cggcauccac     1680

cuguaccagg agagcaccag caagagcgcc cugagccagg aguucgaggc cuucuuccag     1740

ggcaagagcc uguacaucaa cagcggcaac auccccgacu accuguucga cuucuucgag     1800

caccugccca acugcgccag cgcccuggac uucaucaagc uggacuucua cggcggcgcc     1860

auggccagcu gggagaaggc cgccgaggac accggcggca uccacaugga ggaggccccc     1920

gagaccuaca uccccagcag agccgugagc cuguucuuca acuggaagca ggaguucaga     1980

acccuggagg ugacccugag agacuucagc aagcugaaca agcaggacau cagauaccug     2040

ggcaagaucu ucagcagcgc caccagccug agacugcaga ucaagagaug cgccggcgug     2100

gccggcagcc ugagccuggu gcugagcacc ugcaagaaca ucuacagccu gaugguggag     2160

gccagccccc ugaccaucga ggacgagaga cacaucacca gcgugaccaa ccugaagacc     2220

cugagcaucc acgaccugca gaaccagaga cugcccggcg gccugaccga cagccugggc     2280

aaccugaaga accugaccaa gcugaucaug gacaacauca agaugaacga ggaggacgcc     2340

aucaagcugg ccgagggccu gaagaaccug aagaagaugu gccuguucca ccugacccac     2400

cugagcgaca ucggcgaggg cauggacuac aucgugaaga gccugagcag cgagcccugc     2460

gaccuggagg agauccagcu ggugagcugc ugccugagcg ccaacgccgu gaagauccug     2520

gcccagaacc ugcacaaccu ggugaagcug agcauccugg accugagcga gaacuaccug     2580

gagaaggacg gcaacgaggc ccugcacgag cugaucgaca gaaugaacgu gcuggagcag     2640

cugaccgccc ugaugcugcc cuggggcugc gacgugcagg gcagccugag cagccugcug     2700

aagcaccugg aggaggugcc ccagcuggug aagcugggcc ugaagaacug gagacugacc     2760

gacaccgaga ucagaauccu gggcgccuuc uucggcaaga acccccugaa gaacuuccag     2820

cagcugaacc uggccggcaa cagagugagc agcgacggcu ggcuggccuu caugggcgug     2880

uucgagaacc ugaagcagcu gguguucuuc gacuucagca ccaaggaguu ccugcccgac     2940

cccgcccugg ugagaaagcu gagccaggug cugagcaagc ugaccuuccu gcaggaggcc     3000

agacuggugg gcuggcaguu cgacgacgac gaccugagcg ugaucaccgg cgccuucaag     3060

cuggugaccg ccuga                                                      3075


<210>  8940
<211>  3075
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       l_IPAF__Homo_sapiens__AAH31555

<400>  8940
augaacuuca ucaaggacaa uagcagagcc cugauucagc ggaugggcau gaccgugauc       60

aaacaaauua cagaugaccu cuuugucugg aacguucuga aucgcgagga agugaacauc      120

auuugcugug agaaggugga acaggaugcu gccagaggga ucauccacau gauucuuaaa      180

aagggauccg agucuugcaa ucuguuccuc aaaagccuga aggaauggaa cuacccccuu      240

uuucaggacc ugaauggcca gucccucuuc caucaaacgu cugaggggga ucuggacgau      300

cuggcgcagg accucaagga ucuguaucac accccuagcu uucuuaacuu cuacccgcug      360

ggagaggaca ucgauauuau cuuuaaucuc aaauccacau ucaccgaacc cguccugugg      420

cggaaggacc agcaucacca ucgcguggag cagcuuacac ugaacggccu ccugcaagcu      480

cugcagucuc cuuguauuau cgaaggggag agcggaaaag gcaaguccac ccuccugcag      540

agaauugcca ugcuuugggg cagcgggaaa ugcaaggccc ugacaaaguu uaaauucguu      600

uucuuccucc ggcugucucg cgcucaggga ggccuuuuug agacccugug ugaucaacuc      660

cuggacaucc ccgggacgau cagaaagcag accuucaugg ccaugcugcu caaacugcgg      720

cagcgcgugc uuuuccugcu cgacggauau aaugaauuua agccucaaaa cugccccgag      780

auugaagcuc ugaucaaaga gaaucacaga uucaagaaca uggucauugu gacaaccaca      840

accgaauguc uucggcacau ccgccaguuu ggcgcccuga cggcggaggu uggggauaug      900

acagaggacu ccgcccaggc ucucauuaga gaagugcuga ucaaagagcu ggccgaagga      960

cuccugcuuc agauccaaaa gagccggugc cugcgcaauc ucaugaagac cccucuguuc     1020

gucgugauua caugugcuau ccagaugggc gagucugaau uucauuccca cacccagacc     1080

acacuguucc auacguuuua cgaucuucuc auucagaaaa acaagcacaa acacaagggc     1140

guggccgcga gcgacuucau cagaucucug gaucauugcg gggaccuggc ccucgaggga     1200

gucuuuuccc acaaauucga uuuugagcug caagacguua gcuccgugaa cgaagaugug     1260

cuucugacca caggccuccu guguaaguau accgcucagc gguucaagcc gaaauacaag     1320

uuuuuccaua aaucuuucca ggaguauaca gccgggagac gccugagcuc ccuucucacc     1380

agccacgaac ccgaggaagu cacgaaggga aauggcuacc ugcagaaaau ggugucuauu     1440

uccgacauca caagcaccua cucuagccug cuccgguaua ccugcggguc cucuguugag     1500

gcuacaagag ccgugaugaa gcaucuggcc gcugucuacc aacacggaug ccuucugggc     1560

cucagcaucg cgaagcgccc ucuguggcgg caggaguccc ugcagagcgu gaaaaacacc     1620

acagaacagg agauucuuaa ggccaucaau auuaacucuu uuguugaaug uggcauccac     1680

cucuaucaag aguccacgag caaaucugcu cugucccagg aguucgaagc cuuuuuccag     1740

ggaaagagcc uguacauuaa uuccgggaac auccccgauu aucucuuuga cuucuuugag     1800

caucugccua auugcgccuc ugcucuugac uucauuaaac uggauuuuua cggcggggcc     1860

auggcgagcu gggaaaaggc ugccgaggac accggaggca uccacaugga agaggccccc     1920

gagacauaua ucccguccag agcugugucu cucuucuuua acuggaagca agaauuucgc     1980

acccuggagg ucacacugcg ggauuuuagc aaacuuaaua agcaggacau uagauaccuc     2040

gggaaaaucu ucuccagcgc caccucucug cgccugcaga uuaagcggug ugcuggcgug     2100

gccggauccc ucagccuggu ccuuucuacg ugcaaaaaca ucuacucccu gaugguggaa     2160

gcgagcccuc ucaccauuga ggaugaaaga cauaucacau cuguuaccaa ucugaagaca     2220

cugagcaucc acgaccuuca gaaccaacgc cugcccggcg ggcucaccga uucccuggga     2280

aaucucaaaa accugacgaa acuuauuaug gacaauauca agaugaacga ggaggaugcc     2340

auuaagcugg cugaaggccu caagaaccug aaaaagaugu gucuguucca ccuuacacau     2400

cugagcgaca ucggggaggg aauggauuau auugugaaau cucucuccag cgaaccuugc     2460

gaccuggagg aaauccagcu cgucuccugu ugccugucug ccaaugcugu gaagauccuu     2520

gcccagaacc ugcacaaucu cguuaagcug agcauucugg aucuuuccga gaacuaccug     2580

gagaaagacg gcaaugaagc gcuccaugag cugaucgacc ggaugaacgu gcucgaacag     2640

cugaccgccc uuaugcugcc cugggggugu gauguccaag gcucucugag cucccuccug     2700

aagcaccuug aggaggugcc ccagcuggug aaacucggac ugaagaauug gagacucaca     2760

gacaccgaaa uucggauccu gggcgccuuu uucgggaaaa acccucuuaa gaauuuucag     2820

cagcugaacc uggcuggaaa ucgcguuucu agcgauggcu ggcucgcuuu cauggggguc     2880

uuugagaacc ugaagcaacu uguguucuuu gacuucucca ccaaagaauu ucugccggau     2940

cccgcccucg ugagaaagcu gagccagguc cucucuaaac ugacauuccu ucaggaggcc     3000

cggcuggugg gauggcaauu ugacgaugac gaucuguccg uuauuacggg cgcuuucaag     3060

cucgugaccg cguga                                                      3075


<210>  8941
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MDA5__Homo_sapiens__Q9BYX4

<400>  8941

Met Ser Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser 
1               5                   10                  15      


Cys Phe Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu 
            20                  25                  30          


Asp Tyr Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg 
        35                  40                  45              


Thr Val Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser 
    50                  55                  60                  


Thr Leu Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val 
65                  70                  75                  80  


Glu Ala Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn 
                85                  90                  95      


Pro Glu Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp 
            100                 105                 110         


Glu Tyr Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys 
        115                 120                 125             


Leu Leu Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu 
    130                 135                 140                 


Thr Ile Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn 
145                 150                 155                 160 


Glu Ser Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn 
                165                 170                 175     


Trp Phe Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu 
            180                 185                 190         


Leu Val Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu 
        195                 200                 205             


Ile Glu Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu 
    210                 215                 220                 


Leu Ser Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met 
225                 230                 235                 240 


Glu Asn Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser 
                245                 250                 255     


Glu Ser Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu 
            260                 265                 270         


Ser Leu Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly 
        275                 280                 285             


Ser Asp Ser Asp Glu Glu Asn Val Ala Ala Arg Ala Ser Pro Glu Pro 
    290                 295                 300                 


Glu Leu Gln Leu Arg Pro Tyr Gln Met Glu Val Ala Gln Pro Ala Leu 
305                 310                 315                 320 


Glu Gly Lys Asn Ile Ile Ile Cys Leu Pro Thr Gly Ser Gly Lys Thr 
                325                 330                 335     


Arg Val Ala Val Tyr Ile Ala Lys Asp His Leu Asp Lys Lys Lys Lys 
            340                 345                 350         


Ala Ser Glu Pro Gly Lys Val Ile Val Leu Val Asn Lys Val Leu Leu 
        355                 360                 365             


Val Glu Gln Leu Phe Arg Lys Glu Phe Gln Pro Phe Leu Lys Lys Trp 
    370                 375                 380                 


Tyr Arg Val Ile Gly Leu Ser Gly Asp Thr Gln Leu Lys Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Val Val Lys Ser Cys Asp Ile Ile Ile Ser Thr Ala Gln Ile 
                405                 410                 415     


Leu Glu Asn Ser Leu Leu Asn Leu Glu Asn Gly Glu Asp Ala Gly Val 
            420                 425                 430         


Gln Leu Ser Asp Phe Ser Leu Ile Ile Ile Asp Glu Cys His His Thr 
        435                 440                 445             


Asn Lys Glu Ala Val Tyr Asn Asn Ile Met Arg His Tyr Leu Met Gln 
    450                 455                 460                 


Lys Leu Lys Asn Asn Arg Leu Lys Lys Glu Asn Lys Pro Val Ile Pro 
465                 470                 475                 480 


Leu Pro Gln Ile Leu Gly Leu Thr Ala Ser Pro Gly Val Gly Gly Ala 
                485                 490                 495     


Thr Lys Gln Ala Lys Ala Glu Glu His Ile Leu Lys Leu Cys Ala Asn 
            500                 505                 510         


Leu Asp Ala Phe Thr Ile Lys Thr Val Lys Glu Asn Leu Asp Gln Leu 
        515                 520                 525             


Lys Asn Gln Ile Gln Glu Pro Cys Lys Lys Phe Ala Ile Ala Asp Ala 
    530                 535                 540                 


Thr Arg Glu Asp Pro Phe Lys Glu Lys Leu Leu Glu Ile Met Thr Arg 
545                 550                 555                 560 


Ile Gln Thr Tyr Cys Gln Met Ser Pro Met Ser Asp Phe Gly Thr Gln 
                565                 570                 575     


Pro Tyr Glu Gln Trp Ala Ile Gln Met Glu Lys Lys Ala Ala Lys Glu 
            580                 585                 590         


Gly Asn Arg Lys Glu Arg Val Cys Ala Glu His Leu Arg Lys Tyr Asn 
        595                 600                 605             


Glu Ala Leu Gln Ile Asn Asp Thr Ile Arg Met Ile Asp Ala Tyr Thr 
    610                 615                 620                 


His Leu Glu Thr Phe Tyr Asn Glu Glu Lys Asp Lys Lys Phe Ala Val 
625                 630                 635                 640 


Ile Glu Asp Asp Ser Asp Glu Gly Gly Asp Asp Glu Tyr Cys Asp Gly 
                645                 650                 655     


Asp Glu Asp Glu Asp Asp Leu Lys Lys Pro Leu Lys Leu Asp Glu Thr 
            660                 665                 670         


Asp Arg Phe Leu Met Thr Leu Phe Phe Glu Asn Asn Lys Met Leu Lys 
        675                 680                 685             


Arg Leu Ala Glu Asn Pro Glu Tyr Glu Asn Glu Lys Leu Thr Lys Leu 
    690                 695                 700                 


Arg Asn Thr Ile Met Glu Gln Tyr Thr Arg Thr Glu Glu Ser Ala Arg 
705                 710                 715                 720 


Gly Ile Ile Phe Thr Lys Thr Arg Gln Ser Ala Tyr Ala Leu Ser Gln 
                725                 730                 735     


Trp Ile Thr Glu Asn Glu Lys Phe Ala Glu Val Gly Val Lys Ala His 
            740                 745                 750         


His Leu Ile Gly Ala Gly His Ser Ser Glu Phe Lys Pro Met Thr Gln 
        755                 760                 765             


Asn Glu Gln Lys Glu Val Ile Ser Lys Phe Arg Thr Gly Lys Ile Asn 
    770                 775                 780                 


Leu Leu Ile Ala Thr Thr Val Ala Glu Glu Gly Leu Asp Ile Lys Glu 
785                 790                 795                 800 


Cys Asn Ile Val Ile Arg Tyr Gly Leu Val Thr Asn Glu Ile Ala Met 
                805                 810                 815     


Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Glu Ser Thr Tyr Val Leu 
            820                 825                 830         


Val Ala His Ser Gly Ser Gly Val Ile Glu His Glu Thr Val Asn Asp 
        835                 840                 845             


Phe Arg Glu Lys Met Met Tyr Lys Ala Ile His Cys Val Gln Asn Met 
    850                 855                 860                 


Lys Pro Glu Glu Tyr Ala His Lys Ile Leu Glu Leu Gln Met Gln Ser 
865                 870                 875                 880 


Ile Met Glu Lys Lys Met Lys Thr Lys Arg Asn Ile Ala Lys His Tyr 
                885                 890                 895     


Lys Asn Asn Pro Ser Leu Ile Thr Phe Leu Cys Lys Asn Cys Ser Val 
            900                 905                 910         


Leu Ala Cys Ser Gly Glu Asp Ile His Val Ile Glu Lys Met His His 
        915                 920                 925             


Val Asn Met Thr Pro Glu Phe Lys Glu Leu Tyr Ile Val Arg Glu Asn 
    930                 935                 940                 


Lys Ala Leu Gln Lys Lys Cys Ala Asp Tyr Gln Ile Asn Gly Glu Ile 
945                 950                 955                 960 


Ile Cys Lys Cys Gly Gln Ala Trp Gly Thr Met Met Val His Lys Gly 
                965                 970                 975     


Leu Asp Leu Pro Cys Leu Lys Ile Arg Asn Phe Val Val Val Phe Lys 
            980                 985                 990         


Asn Asn Ser Thr Lys Lys Gln Tyr Lys Lys Trp Val Glu Leu Pro Ile 
        995                 1000                1005            


Thr Phe Pro Asn Leu Asp Tyr Ser Glu Cys Cys Leu Phe Ser Asp Glu 
    1010                1015                1020                


Asp 
1025


<210>  8942
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MDA5__Homo_sapiens__CCDS2217.1

<400>  8942
augucgaaug gguauuccac agacgagaau uuccgcuauc ucaucucgug cuucagggcc       60

agggugaaaa uguacaucca gguggagccu gugcuggacu accugaccuu ucugccugca      120

gaggugaagg agcagauuca gaggacaguc gccaccuccg ggaacaugca ggcaguugaa      180

cugcugcuga gcaccuugga gaagggaguc uggcaccuug guuggacucg ggaauucgug      240

gaggcccucc ggagaaccgg cagcccucug gccgcccgcu acaugaaccc ugagcucacg      300

gacuugcccu cuccaucguu ugagaacgcu caugaugaau aucuccaacu gcugaaccuc      360

cuucagccca cucuggugga caagcuucua guuagagacg ucuuggauaa gugcauggag      420

gaggaacugu ugacaauuga agacagaaac cggauugcug cugcagaaaa caauggaaau      480

gaaucaggug uaagagagcu acuaaaaagg auugugcaga aagaaaacug guucucugca      540

uuucugaaug uucuucguca aacaggaaac aaugaacuug uccaagaguu aacaggcucu      600

gauugcucag aaagcaaugc agagauugag aauuuaucac aaguugaugg uccucaagug      660

gaagagcaac uucuuucaac cacaguucag ccaaaucugg agaaggaggu cuggggcaug      720

gagaauaacu caucagaauc aucuuuugca gauucuucug uaguuucaga aucagacaca      780

aguuuggcag aaggaagugu cagcugcuua gaugaaaguc uuggacauaa cagcaacaug      840

ggcagugauu caggcaccau gggaagugau ucagaugaag agaauguggc agcaagagca      900

uccccggagc cagaacucca gcucaggccu uaccaaaugg aaguugccca gccagccuug      960

gaagggaaga auaucaucau cugccucccu acagggagug gaaaaaccag aguggcuguu     1020

uacauugcca aggaucacuu agacaagaag aaaaaagcau cugagccugg aaaaguuaua     1080

guucuuguca auaagguacu gcuaguugaa cagcucuucc gcaaggaguu ccaaccauuu     1140

uugaagaaau gguaucgugu uauuggauua aguggugaua cccaacugaa aauaucauuu     1200

ccagaaguug ucaaguccug ugauauuauu aucaguacag cucaaauccu ugaaaacucc     1260

cucuuaaacu uggaaaaugg agaagaugcu gguguucaau ugucagacuu uucccucauu     1320

aucauugaug aaugucauca caccaacaaa gaagcagugu auaauaacau caugaggcau     1380

uauuugaugc agaaguugaa aaacaauaga cucaagaaag aaaacaaacc agugauuccc     1440

cuuccucaga uacugggacu aacagcuuca ccugguguug gaggggccac gaagcaagcc     1500

aaagcugaag aacacauuuu aaaacuaugu gccaaucuug augcauuuac uauuaaaacu     1560

guuaaagaaa accuugauca acugaaaaac caaauacagg agccaugcaa gaaguuugcc     1620

auugcagaug caaccagaga agauccauuu aaagagaaac uucuagaaau aaugacaagg     1680

auucaaacuu auugucaaau gaguccaaug ucagauuuug gaacucaacc cuaugaacaa     1740

ugggccauuc aaauggaaaa aaaagcugca aaagaaggaa aucgcaaaga acguguuugu     1800

gcagaacauu ugaggaagua caaugaggcc cuacaaauua augacacaau ucgaaugaua     1860

gaugcguaua cucaucuuga aacuuucuau aaugaagaga aagauaagaa guuugcaguc     1920

auagaagaug auagugauga ggguggugau gaugaguauu gugaugguga ugaagaugag     1980

gaugauuuaa agaaaccuuu gaaacuggau gaaacagaua gauuucucau gacuuuauuu     2040

uuugaaaaca auaaaauguu gaaaaggcug gcugaaaacc cagaauauga aaaugaaaag     2100

cugaccaaau uaagaaauac cauaauggag caauauacua ggacugagga aucagcacga     2160

ggaauaaucu uuacaaaaac acgacagagu gcauaugcgc uuucccagug gauuacugaa     2220

aaugaaaaau uugcugaagu aggagucaaa gcccaccauc ugauuggagc uggacacagc     2280

agugaguuca aacccaugac acagaaugaa caaaaagaag ucauuaguaa auuucgcacu     2340

ggaaaaauaa aucugcuuau cgcuaccaca guggcagaag aaggucugga uauuaaagaa     2400

uguaacauug uuauccguua uggucucguc accaaugaaa uagccauggu ccaggcccgu     2460

ggucgagcca gagcugauga gagcaccuac guccugguug cucacagugg uucaggaguu     2520

aucgaacaug agacaguuaa ugauuuccga gagaagauga uguauaaagc uauacauugu     2580

guucaaaaua ugaaaccaga ggaguaugcu cauaagauuu uggaauuaca gaugcaaagu     2640

auaauggaaa agaaaaugaa aaccaagaga aauauugcca agcauuacaa gaauaaccca     2700

ucacuaauaa cuuuccuuug caaaaacugc agugugcuag ccuguucugg ggaagauauc     2760

cauguaauug agaaaaugca ucacgucaau augaccccag aauucaagga acuuuacauu     2820

guaagagaaa acaaagcacu gcaaaagaag ugugccgacu aucaaauaaa uggugaaauc     2880

aucugcaaau guggccaggc uuggggaaca augauggugc acaaaggcuu agauuugccu     2940

ugucucaaaa uaaggaauuu uguagugguu uucaaaaaua auucaacaaa gaaacaauac     3000

aaaaaguggg uagaauuacc uaucacauuu cccaaucuug acuauucaga augcuguuua     3060

uuuagugaug aggauuag                                                   3078


<210>  8943
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MDA5__Homo_sapiens__CCDS2217.1

<400>  8943
augagcaacg gcuacuccac cgacgagaac uuccgcuacc ugaucagcug cuuccgggcc       60

cgcgugaaga uguacaucca ggucgagccc gugcucgacu accugaccuu ccugccggcc      120

gaggugaagg agcagaucca gcggacgguc gcgaccuccg ggaacaugca ggccguggag      180

cuccugcuga gcacccucga gaagggcgug uggcaccugg gguggacccg cgaguucguc      240

gaggcccugc ggcgcacggg cagcccccuc gccgcccggu acaugaaccc cgagcugacc      300

gaccugcccu ccccguccuu cgagaacgcg cacgacgagu accuccagcu gcugaaccuc      360

cugcagccca cccuggugga caagcuccug gugcgcgacg uccuggacaa gugcauggag      420

gaggagcucc ugaccaucga ggaccggaac cgcaucgccg ccgccgagaa caacgggaac      480

gagagcggcg ugcgggagcu gcucaagcgc aucgugcaga aggagaacug guucuccgcg      540

uuccugaacg uccugcggca gacgggcaac aacgagcucg ugcaggagcu gaccgggagc      600

gacugcuccg agagcaacgc cgagaucgag aaccuguccc agguggacgg cccccagguc      660

gaggagcagc uccugagcac caccgugcag cccaaccugg agaaggaggu gugggggaug      720

gagaacaacu ccagcgaguc cagcuucgcc gacuccagcg ucgugagcga guccgacacg      780

agccucgccg agggcuccgu gagcugccug gacgaguccc uggggcacaa cagcaacaug      840

ggcuccgaca gcggcaccau gggguccgac agcgacgagg agaacgucgc cgcgcgcgcc      900

uccccggagc ccgagcucca gcugcggccc uaccagaugg agguggccca gcccgcccug      960

gagggcaaga acaucaucau cugccucccg accgggagcg gcaagacccg cguggccguc     1020

uacaucgcga aggaccaccu ggacaagaag aagaaggccu ccgagcccgg caaggugauc     1080

guccugguga acaaggugcu ccuggucgag cagcuguucc ggaaggaguu ccagcccuuc     1140

cucaagaagu gguaccgcgu gaucgggcug agcggcgaca cgcagcugaa gaucuccuuc     1200

cccgaggugg ucaagagcug cgacaucauc aucuccaccg cccagauccu cgagaacagc     1260

cugcugaacc uggagaacgg ggaggacgcc ggcgugcagc ucuccgacuu cagccugauc     1320

aucaucgacg agugccacca caccaacaag gaggccgugu acaacaacau caugcggcac     1380

uaccugaugc agaagcucaa gaacaaccgc cugaagaagg agaacaagcc ggucaucccc     1440

cugccccaga uccucgggcu gaccgcgagc cccggcgugg gcggggccac gaagcaggcc     1500

aaggccgagg agcacauccu gaagcucugc gccaaccugg acgcguucac caucaagacc     1560

gugaaggaga accuggacca gcucaagaac cagauccagg agccgugcaa gaaguucgcc     1620

aucgccgacg ccacccggga ggaccccuuc aaggagaagc ugcuggagau caugacgcgc     1680

auccagaccu acugccagau gucccccaug agcgacuucg gcacccagcc cuacgagcag     1740

ugggcgaucc agauggagaa gaaggccgcc aaggagggga accgcaagga gcgggucugc     1800

gccgagcacc uccgcaagua caacgaggcc cugcagauca acgacaccau ccggaugauc     1860

gacgcguaca cgcaccugga gaccuucuac aacgaggaga aggacaagaa guucgccgug     1920

aucgaggacg acuccgacga gggcggggac gacgaguacu gcgacggcga cgaggacgag     1980

gacgaccuca agaagccgcu gaagcuggac gagaccgacc gcuuccucau gacccuguuc     2040

uucgagaaca acaagaugcu gaagcggcuc gccgagaacc ccgaguacga gaacgagaag     2100

cugacgaagc ugcgcaacac caucauggag caguacaccc ggaccgagga gagcgcccgc     2160

ggcaucaucu ucacgaagac ccggcagucc gccuacgcgc ucagccagug gaucaccgag     2220

aacgagaagu ucgccgaggu gggggucaag gcccaccacc ugaucggcgc cgggcacucc     2280

agcgaguuca agcccaugac ccagaacgag cagaaggagg ugaucuccaa guuccgcacc     2340

ggcaagauca accugcucau cgccacgacc guggcggagg aggggcugga caucaaggag     2400

ugcaacaucg ucauccggua cggccuggug accaacgaga ucgccauggu gcaggcccgc     2460

ggccgggccc gcgcggacga gagcaccuac guccucgugg cccacuccgg gagcggcgug     2520

aucgagcacg agacggucaa cgacuuccgg gagaagauga uguacaaggc cauccacugc     2580

gugcagaaca ugaagcccga ggaguacgcc cacaagaucc uggagcugca gaugcagucc     2640

aucauggaga agaagaugaa gaccaagcgc aacaucgcca agcacuacaa gaacaacccg     2700

agccucauca ccuuccugug caagaacugc uccgugcugg cgugcagcgg ggaggacauc     2760

cacgucaucg agaagaugca ccacgugaac augacccccg aguucaagga gcucuacauc     2820

gugcgggaga acaaggcccu gcagaagaag ugcgccgacu accagaucaa cggcgagauc     2880

aucugcaagu gcggccaggc cugggggacg augauggucc acaagggccu ggaccucccc     2940

ugccugaaga uccgcaacuu cguggugguc uucaagaaca acuccaccaa gaagcaguac     3000

aagaaguggg uggagcugcc gaucaccuuc cccaaccucg acuacagcga gugcugccug     3060

uucagcgacg aggacuga                                                   3078


<210>  8944
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MDA5__Homo_sapiens__CCDS2217.1

<400>  8944
auguccaacg gcuacuccac cgacgagaac uuccgcuacc ucaucuccug cuuccgcgcc       60

cgcgucaaga uguacaucca ggucgagccc guccucgacu accucaccuu ccuccccgcc      120

gaggucaagg agcagaucca gcgcaccguc gccaccuccg gcaacaugca ggccgucgag      180

cuccuccucu ccacccucga gaagggcguc uggcaccucg gcuggacccg cgaguucguc      240

gaggcccucc gccgcaccgg cuccccccuc gccgcccgcu acaugaaccc cgagcucacc      300

gaccuccccu cccccuccuu cgagaacgcc cacgacgagu accuccagcu ccucaaccuc      360

cuccagccca cccucgucga caagcuccuc guccgcgacg uccucgacaa gugcauggag      420

gaggagcucc ucaccaucga ggaccgcaac cgcaucgccg ccgccgagaa caacggcaac      480

gaguccggcg uccgcgagcu ccucaagcgc aucguccaga aggagaacug guucuccgcc      540

uuccucaacg uccuccgcca gaccggcaac aacgagcucg uccaggagcu caccggcucc      600

gacugcuccg aguccaacgc cgagaucgag aaccucuccc aggucgacgg cccccagguc      660

gaggagcagc uccucuccac caccguccag cccaaccucg agaaggaggu cuggggcaug      720

gagaacaacu ccuccgaguc cuccuucgcc gacuccuccg ucgucuccga guccgacacc      780

ucccucgccg agggcuccgu cuccugccuc gacgaguccc ucggccacaa cuccaacaug      840

ggcuccgacu ccggcaccau gggcuccgac uccgacgagg agaacgucgc cgcccgcgcc      900

ucccccgagc ccgagcucca gcuccgcccc uaccagaugg aggucgccca gcccgcccuc      960

gagggcaaga acaucaucau cugccucccc accggcuccg gcaagacccg cgucgccguc     1020

uacaucgcca aggaccaccu cgacaagaag aagaaggccu ccgagcccgg caaggucauc     1080

guccucguca acaagguccu ccucgucgag cagcucuucc gcaaggaguu ccagcccuuc     1140

cucaagaagu gguaccgcgu caucggccuc uccggcgaca cccagcucaa gaucuccuuc     1200

cccgaggucg ucaaguccug cgacaucauc aucuccaccg cccagauccu cgagaacucc     1260

cuccucaacc ucgagaacgg cgaggacgcc ggcguccagc ucuccgacuu cucccucauc     1320

aucaucgacg agugccacca caccaacaag gaggccgucu acaacaacau caugcgccac     1380

uaccucaugc agaagcucaa gaacaaccgc cucaagaagg agaacaagcc cgucaucccc     1440

cucccccaga uccucggccu caccgccucc cccggcgucg gcggcgccac caagcaggcc     1500

aaggccgagg agcacauccu caagcucugc gccaaccucg acgccuucac caucaagacc     1560

gucaaggaga accucgacca gcucaagaac cagauccagg agcccugcaa gaaguucgcc     1620

aucgccgacg ccacccgcga ggaccccuuc aaggagaagc uccucgagau caugacccgc     1680

auccagaccu acugccagau gucccccaug uccgacuucg gcacccagcc cuacgagcag     1740

ugggccaucc agauggagaa gaaggccgcc aaggagggca accgcaagga gcgcgucugc     1800

gccgagcacc uccgcaagua caacgaggcc cuccagauca acgacaccau ccgcaugauc     1860

gacgccuaca cccaccucga gaccuucuac aacgaggaga aggacaagaa guucgccguc     1920

aucgaggacg acuccgacga gggcggcgac gacgaguacu gcgacggcga cgaggacgag     1980

gacgaccuca agaagccccu caagcucgac gagaccgacc gcuuccucau gacccucuuc     2040

uucgagaaca acaagaugcu caagcgccuc gccgagaacc ccgaguacga gaacgagaag     2100

cucaccaagc uccgcaacac caucauggag caguacaccc gcaccgagga guccgcccgc     2160

ggcaucaucu ucaccaagac ccgccagucc gccuacgccc ucucccagug gaucaccgag     2220

aacgagaagu ucgccgaggu cggcgucaag gcccaccacc ucaucggcgc cggccacucc     2280

uccgaguuca agcccaugac ccagaacgag cagaaggagg ucaucuccaa guuccgcacc     2340

ggcaagauca accuccucau cgccaccacc gucgccgagg agggccucga caucaaggag     2400

ugcaacaucg ucauccgcua cggccucguc accaacgaga ucgccauggu ccaggcccgc     2460

ggccgcgccc gcgccgacga guccaccuac guccucgucg cccacuccgg cuccggcguc     2520

aucgagcacg agaccgucaa cgacuuccgc gagaagauga uguacaaggc cauccacugc     2580

guccagaaca ugaagcccga ggaguacgcc cacaagaucc ucgagcucca gaugcagucc     2640

aucauggaga agaagaugaa gaccaagcgc aacaucgcca agcacuacaa gaacaacccc     2700

ucccucauca ccuuccucug caagaacugc uccguccucg ccugcuccgg cgaggacauc     2760

cacgucaucg agaagaugca ccacgucaac augacccccg aguucaagga gcucuacauc     2820

guccgcgaga acaaggcccu ccagaagaag ugcgccgacu accagaucaa cggcgagauc     2880

aucugcaagu gcggccaggc cuggggcacc augauggucc acaagggccu cgaccucccc     2940

ugccucaaga uccgcaacuu cgucgucguc uucaagaaca acuccaccaa gaagcaguac     3000

aagaaguggg ucgagcuccc caucaccuuc cccaaccucg acuacuccga gugcugccuc     3060

uucuccgacg aggacuga                                                   3078


<210>  8945
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MDA5__Homo_sapiens__CCDS2217.1

<400>  8945
augagcaacg gcuacuccac cgacgagaau uucagauauc ugaucucuug cuuuagggcc       60

cgggugaaga uguacauuca ggucgaaccc guucucgauu aucuuacauu ccugccugcu      120

gaggugaaag aacaaauaca gcgcacugua gcaacgucag ggaacaugca ggccguggag      180

uuguuacuga guacccuaga aaagggaguc uggcaccucg guuggacacg agaguuugug      240

gaggcgcugc guagaacugg cagcccacuu gcugccaggu acaugaaucc ggaacugacc      300

gacuugcccu ccccuucuuu cgagaacgca caugaugaau aucuccagcu gcugaaucuc      360

uuacaaccaa cacugguuga caaacuuuug gugcgggaug uccuggacaa guguauggag      420

gaggaacuac ucaccaucga ggaucgcaac agaauugccg cugcagaaaa uaacgggaau      480

gagucgggag ugagggaacu gcuuaaacgg aucguacaga aggagaacug guuuucagcc      540

uuccugaaug uuuugcgcca gacuggcaac aaugagcucg ugcaggaacu gacagguagc      600

gacugcagug aguccaacgc ugaaauugag aauuuaucuc aagucgaugg gccccaggug      660

gaagaacagc ugcucagcac cacggugcag ccuaaccuug agaaggaagu cuggggaaug      720

gagaacaauu ccucagaaag uagcuuugcc gacucuuccg uugugucaga gagcgauacc      780

agucuggcgg aaggcucugu auccuguuug gacgagagcc uaggccacaa cucgaauaug      840

gggucugauu ccggaacuau ggguucagac agugacgagg aaaacguggc agcccgagcu      900

agcccagagc ccgaacugca acucagaccu uaccagaugg aggucgccca gccagcacug      960

gagggcaaaa auaucauaau cugccuuccg acaggguccg gaaagacuag gguggcuguu     1020

uauauugcca aagaucaucu ggacaagaaa aagaaggcgu cugaacccgg caaagugauc     1080

gucuugguga acaagguacu ccugguugag caauuauucc ggaaagaauu ucagccuuuc     1140

cugaagaaau gguaccgugu gauuggucua agcggggaua cccagcucaa gaucucauuu     1200

ccagaggucg ugaaaaguug ugacauaauu aucuccacag cccagauucu ggaaaauagc     1260

cuuuugaacc uggagaaugg agaggaugca ggcguccaac ucucugacuu cucacugauc     1320

aucauugaug aaugccacca uaccaacaag gaggcugugu acaauaacau aaugcgccac     1380

uaucuuaugc agaagcugaa aaauaacaga uugaagaaag aaaauaagcc cguuaucccu     1440

cucccacaga uucugggcuu aacggccagu cccggggugg gaggugcuac uaaacaggcc     1500

aaggcagagg aacacauccu gaagcuaugu gccaaccucg acgcuuuuac aauaaaaacc     1560

guaaaggaga accuggauca acuuaaaaau cagauucagg agccgugcaa gaaauucgcg     1620

aucgcagacg ccacuaggga agauccuuuc aaggagaagu ugcuggaaau caugacacgg     1680

auucagaccu acugucaaau gagccccaug uccgacuuug gcacgcagcc auaugagcag     1740

ugggcuaucc agauggagaa aaaggccgca aaagagggga accgaaagga gcgcgucugc     1800

gccgaacauc ucagaaaaua caaugaggcu cugcaaauua acgacaccau aaggaugauc     1860

gaugccuaua cacacuuaga aacuuucuac aaugaggaga aggacaagaa auuugcagug     1920

auugaagaug acucugauga gggaggcgac gaugaauauu gugacgguga ugaggacgaa     1980

gaugaccuga agaaaccucu uaaguuggau gagaccgacc gguuccucau gacacuguuu     2040

uucgagaaca auaaaaugcu aaagcgccug gcggaaaacc ccgaguacga aaaugagaaa     2100

cucacuaagc ugagaaacac caucauggaa caguacacaa ggaccgagga gucggcucgu     2160

gggaucauuu uuacuaagac gcggcagagc gccuaugcac uuucccaaug gauaacagaa     2220

aaugagaaau ucgccgaagu uggcgugaag gcucaucacu ugaucggagc cggccacuca     2280

agugaguuua aaccaaugac ccagaacgaa cagaaggagg ucauuucuaa auuccgaacu     2340

gggaagauca aucuguuaau ugcaaccaca guggcugagg aaggacucga caucaaggag     2400

ugcaacauag uaaucagaua cggucuggug accaaugaaa uugccauggu ucaggcgagg     2460

ggccgcgccc gggcugauga gagcacuuau guccuugugg cacauuccgg gucaggagug     2520

aucgagcacg aaacagucaa cgacuuuaga gagaaaauga uguacaaggc cauucauugc     2580

guucaaaaca ugaaacccga agaguaugcu cacaagaucc uggaauugca gaugcagagc     2640

auaauggaga aaaagaugaa gacgaaaagg aauauugcca agcauuacaa aaacaauccu     2700

ucucucauca ccuuccugug uaagaacugc uccgugcuag cauguagugg cgaggauauu     2760

cacgugaucg agaaaaugca ccauguaaau augacuccag aauuuaagga acuguauaua     2820

guccgcgaga acaaggcgcu ccagaaaaag ugcgccgacu accaaaucaa uggugaaauu     2880

aucuguaaau gcgggcaggc uuggggcaca augauggugc acaagggacu ggaucuuccg     2940

uguuugaaaa uucgaaacuu cguugugguc uucaagaaua acagcaccaa aaagcaguac     3000

aagaaauggg uggagcugcc caucacauuu ccuaauuuag acuauucuga gugcugucuc     3060

uucuccgaug aagacuga                                                   3078


<210>  8946
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MDA5__Homo_sapiens__CCDS2217.1

<400>  8946
augagcaacg gcuacagcac cgacgagaac uucagauacc ugaucagcug cuucagagcc       60

agagugaaga uguacaucca gguggagccc gugcuggacu accugaccuu ccugcccgcc      120

gaggugaagg agcagaucca gagaaccgug gccaccagcg gcaacaugca ggccguggag      180

cugcugcuga gcacccugga gaagggcgug uggcaccugg gcuggaccag agaguucgug      240

gaggcccuga gaagaaccgg cagcccccug gccgccagau acaugaaccc cgagcugacc      300

gaccugccca gccccagcuu cgagaacgcc cacgacgagu accugcagcu gcugaaccug      360

cugcagccca cccuggugga caagcugcug gugagagacg ugcuggacaa gugcauggag      420

gaggagcugc ugaccaucga ggacagaaac agaaucgccg ccgccgagaa caacggcaac      480

gagagcggcg ugagagagcu gcugaagaga aucgugcaga aggagaacug guucagcgcc      540

uuccugaacg ugcugagaca gaccggcaac aacgagcugg ugcaggagcu gaccggcagc      600

gacugcagcg agagcaacgc cgagaucgag aaccugagcc agguggacgg cccccaggug      660

gaggagcagc ugcugagcac caccgugcag cccaaccugg agaaggaggu guggggcaug      720

gagaacaaca gcagcgagag cagcuucgcc gacagcagcg uggugagcga gagcgacacc      780

agccuggccg agggcagcgu gagcugccug gacgagagcc ugggccacaa cagcaacaug      840

ggcagcgaca gcggcaccau gggcagcgac agcgacgagg agaacguggc cgccagagcc      900

agccccgagc ccgagcugca gcugagaccc uaccagaugg agguggccca gcccgcccug      960

gagggcaaga acaucaucau cugccugccc accggcagcg gcaagaccag aguggccgug     1020

uacaucgcca aggaccaccu ggacaagaag aagaaggcca gcgagcccgg caaggugauc     1080

gugcugguga acaaggugcu gcugguggag cagcuguuca gaaaggaguu ccagcccuuc     1140

cugaagaagu gguacagagu gaucggccug agcggcgaca cccagcugaa gaucagcuuc     1200

cccgaggugg ugaagagcug cgacaucauc aucagcaccg cccagauccu ggagaacagc     1260

cugcugaacc uggagaacgg cgaggacgcc ggcgugcagc ugagcgacuu cagccugauc     1320

aucaucgacg agugccacca caccaacaag gaggccgugu acaacaacau caugagacac     1380

uaccugaugc agaagcugaa gaacaacaga cugaagaagg agaacaagcc cgugaucccc     1440

cugccccaga uccugggccu gaccgccagc cccggcgugg gcggcgccac caagcaggcc     1500

aaggccgagg agcacauccu gaagcugugc gccaaccugg acgccuucac caucaagacc     1560

gugaaggaga accuggacca gcugaagaac cagauccagg agcccugcaa gaaguucgcc     1620

aucgccgacg ccaccagaga ggaccccuuc aaggagaagc ugcuggagau caugaccaga     1680

auccagaccu acugccagau gagccccaug agcgacuucg gcacccagcc cuacgagcag     1740

ugggccaucc agauggagaa gaaggccgcc aaggagggca acagaaagga gagagugugc     1800

gccgagcacc ugagaaagua caacgaggcc cugcagauca acgacaccau cagaaugauc     1860

gacgccuaca cccaccugga gaccuucuac aacgaggaga aggacaagaa guucgccgug     1920

aucgaggacg acagcgacga gggcggcgac gacgaguacu gcgacggcga cgaggacgag     1980

gacgaccuga agaagccccu gaagcuggac gagaccgaca gauuccugau gacccuguuc     2040

uucgagaaca acaagaugcu gaagagacug gccgagaacc ccgaguacga gaacgagaag     2100

cugaccaagc ugagaaacac caucauggag caguacacca gaaccgagga gagcgccaga     2160

ggcaucaucu ucaccaagac cagacagagc gccuacgccc ugagccagug gaucaccgag     2220

aacgagaagu ucgccgaggu gggcgugaag gcccaccacc ugaucggcgc cggccacagc     2280

agcgaguuca agcccaugac ccagaacgag cagaaggagg ugaucagcaa guucagaacc     2340

ggcaagauca accugcugau cgccaccacc guggccgagg agggccugga caucaaggag     2400

ugcaacaucg ugaucagaua cggccuggug accaacgaga ucgccauggu gcaggccaga     2460

ggcagagcca gagccgacga gagcaccuac gugcuggugg cccacagcgg cagcggcgug     2520

aucgagcacg agaccgugaa cgacuucaga gagaagauga uguacaaggc cauccacugc     2580

gugcagaaca ugaagcccga ggaguacgcc cacaagaucc uggagcugca gaugcagagc     2640

aucauggaga agaagaugaa gaccaagaga aacaucgcca agcacuacaa gaacaacccc     2700

agccugauca ccuuccugug caagaacugc agcgugcugg ccugcagcgg cgaggacauc     2760

cacgugaucg agaagaugca ccacgugaac augacccccg aguucaagga gcuguacauc     2820

gugagagaga acaaggcccu gcagaagaag ugcgccgacu accagaucaa cggcgagauc     2880

aucugcaagu gcggccaggc cuggggcacc augauggugc acaagggccu ggaccugccc     2940

ugccugaaga ucagaaacuu cgugguggug uucaagaaca acagcaccaa gaagcaguac     3000

aagaaguggg uggagcugcc caucaccuuc cccaaccugg acuacagcga gugcugccug     3060

uucagcgacg aggacuga                                                   3078


<210>  8947
<211>  3078
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MDA5__Homo_sapiens__CCDS2217.1

<400>  8947
augagcaacg gcuacuccac cgacgagaau uucagauauc ugaucucuug cuuucgggcc       60

cgcgugaaga uguacauuca ggucgaaccc guucucgauu aucugacauu ccuuccugcu      120

gaggugaaag aacaaaucca gagaacggug gccaccagcg ggaacaugca ggcggucgag      180

cugcuccugu ccacacuuga aaagggagug uggcaccugg gcuggacccg ggaguuuguu      240

gaggcucucc gcagaacagg gucuccgcug gccgcccggu acaugaaucc cgaacugacc      300

gaccucccua gccccuccuu cgagaacgcu caugaugaau aucugcagcu ucugaaucuc      360

cugcaaccua cacuugugga caaacugcuc guccgcgaug ugcuggacaa guguauggag      420

gaggaacugc ucaccauuga ggauagaaac cggaucgccg cugccgaaaa uaacggaaau      480

gagucuggcg uucgcgaacu gcuuaaaaga auugugcaga aggagaacug guuuagcgcg      540

uuccugaaug uccuccggca gacggggaac aaugagcugg ugcaggaacu uaccggaucc      600

gacugcagcg agucuaacgc cgaaaucgag aaucuguccc aaguggaugg cccccagguc      660

gaagaacagc uccugagcac aaccguucag ccuaaccugg agaaggaagu guggggcaug      720

gagaacaauu cuuccgaaag cucuuuugcu gacuccagcg uggucuccga gucugauaca      780

agccucgccg aaggguccgu gagcugucug gacgagucuc uuggacacaa cuccaauaug      840

ggcagcgauu cugggaccau gggaagcgac uccgacgagg aaaacguugc ugcccgcgcg      900

ucuccggagc ccgaacugca acucagaccu uaccagaugg agguggccca gcccgcucug      960

gagggcaaaa auaucauuau cugccuuccu acggggagcg gaaagacacg ggucgccgug     1020

uauauugcua aagaucaucu ggacaagaaa aagaaggccu ccgaacccgg caaaguuauc     1080

gugcucguca acaaggugcu gcuggucgag caacucuucc gcaaagaauu ucagccguuc     1140

cugaagaaau gguacagagu gauuggccuu agcggggaua cccagcugaa gaucucuuuu     1200

ccugagguug ugaaauccug ugacauuauc aucagcacag cccagauucu cgaaaauucu     1260

cugcugaacc uugagaaugg agaggaugcu ggcguccaac ucuccgacuu cagccugauc     1320

auuaucgaug aaugccacca uaccaacaag gaggcggugu acaauaacau uaugcggcac     1380

uaucugaugc agaagcucaa aaauaacaga cugaagaaag aaaauaagcc cguuaucccu     1440

cuuccccaga uccuggggcu caccgccucc cccggagugg gcggggcuac aaaacaggcc     1500

aaggccgagg aacacauucu gaagcugugu gcuaaccuug acgccuuuac gaucaaaacc     1560

gucaaggaga accucgauca acugaaaaau cagauucagg agccuugcaa gaaauucgcg     1620

aucgcugacg ccacacgcga agauccguuc aaggagaagc ugcucgaaau uaugacccgg     1680

auccagacau acugucaaau gucucccaug agcgacuuug gaacccagcc uuaugagcag     1740

ugggccaucc agauggagaa aaaggcugcc aaagagggca acagaaagga gcgcgugugc     1800

gcugaacauc ugcggaaaua caaugaggcc cuucaaauua acgacacgau cagaaugauu     1860

gaugcguaua cacaccugga aaccuucuac aaugaggaga aggacaagaa auuugccgug     1920

aucgaagaug acuccgauga gggcggggac gaugaauauu gugacggaga ugaggacgaa     1980

gaugaccuca agaaaccccu gaagcuggau gagaccgacc gcuuccuuau gacacucuuu     2040

uucgagaaca auaaaaugcu gaagcggcug gcugaaaacc cugaguacga aaaugagaaa     2100

cucaccaagc ugagaaacac aauuauggaa caguacacgc gcaccgagga gucugcccgg     2160

ggcaucauuu uuacaaagac cagacagagc gcuuaugccc uuucccaaug gaucacagaa     2220

aaugagaaau ucgcggaagu uggggucaag gcccaucacc ugaucggagc uggccacagc     2280

ucugaguuua aacccaugac ccagaacgaa cagaaggagg ugauuuccaa auuccgcacg     2340

gggaagauca aucuccugau ugccaccaca guggcugagg aaggccugga caucaaggag     2400

ugcaacauug ucauccggua cggacuugug accaaugaaa ucgccauggu ucaggccaga     2460

ggccgggcuc gcgcggauga gagcacauau gugcucgucg cccauucugg guccggagug     2520

auugagcacg aaaccguuaa cgacuuuaga gagaaaauga uguacaaggc uauccauugc     2580

gugcaaaaca ugaaaccgga agaguaugcc cacaagauuc uggaacugca gaugcagagc     2640

aucauggaga aaaagaugaa gacgaaacgg aauauugcca agcauuacaa aaacaauccu     2700

ucucucauca cauuccugug uaagaacugc agcguccuug cuuguuccgg cgaggauauc     2760

cacgugauug agaaaaugca ccauguuaau augacccccg aauuuaagga acuguauauc     2820

gugagagaga acaaggcccu ccagaaaaag ugcgcggacu accaaauuaa uggggaaauc     2880

auuuguaaau gcggacaggc uuggggcaca augauggucc acaaggggcu ggaucugccu     2940

ugucuuaaaa uccgcaacuu cguggugguc uucaagaaua acagcaccaa aaagcaguac     3000

aagaaauggg uugagcugcc caucaccuuu ccuaaucucg acuauucuga gugcugucug     3060

uucuccgaug aagacuga                                                   3078


<210>  8948
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MK11__Homo_sapiens__Q15759

<400>  8948

Met Ser Gly Pro Arg Ala Gly Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Val Trp Glu Val Pro Gln Arg Leu Gln Gly Leu Arg Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ser Ala Tyr Asp Ala Arg Leu Arg Gln 
        35                  40                  45              


Lys Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Leu Ile His 
    50                  55                  60                  


Ala Arg Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Leu Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Thr Ser Ile 
                85                  90                  95      


Glu Asp Phe Ser Glu Val Tyr Leu Val Thr Thr Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Ala Leu Ser Asp Glu His Val Gln 
        115                 120                 125             


Phe Leu Val Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Val Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Arg Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Asp 
                165                 170                 175     


Glu Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Gln Gly Lys Ala Leu Phe Pro 
    210                 215                 220                 


Gly Ser Asp Tyr Ile Asp Gln Leu Lys Arg Ile Met Glu Val Val Gly 
225                 230                 235                 240 


Thr Pro Ser Pro Glu Val Leu Ala Lys Ile Ser Ser Glu His Ala Arg 
                245                 250                 255     


Thr Tyr Ile Gln Ser Leu Pro Pro Met Pro Gln Lys Asp Leu Ser Ser 
            260                 265                 270         


Ile Phe Arg Gly Ala Asn Pro Leu Ala Ile Asp Leu Leu Gly Arg Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Gln Arg Val Ser Ala Ala Glu Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ser Gln Tyr His Asp Pro Glu Asp Glu Pro Glu Ala 
305                 310                 315                 320 


Glu Pro Tyr Asp Glu Ser Val Glu Ala Lys Glu Arg Thr Leu Glu Glu 
                325                 330                 335     


Trp Lys Glu Leu Thr Tyr Gln Glu Val Leu Ser Phe Lys Pro Pro Glu 
            340                 345                 350         


Pro Pro Lys Pro Pro Gly Ser Leu Glu Ile Glu Gln 
        355                 360                 


<210>  8949
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MK11__Homo_sapiens__AAC12714

<400>  8949
augucgggcc cucgcgccgg cuucuaccgg caggagcuga acaagaccgu gugggaggug       60

ccgcagcggc ugcaggggcu gcgcccggug ggcuccggcg ccuacggcuc cgucuguucg      120

gccuacgacg cccggcugcg ccagaaggug gcggugaaga agcugucgcg ccccuuccag      180

ucgcugaucc acgcgcgcag aacguaccgg gagcugcggc ugcucaagca ccugaagcac      240

gagaacguca ucgggcuucu ggacgucuuc acgccggcca cguccaucga ggacuucagc      300

gaaguguacu uggugaccac ccugaugggc gccgaccuga acaacaucgu caagugccag      360

gcgcugagcg acgagcacgu ucaauuccug guuuaccagc ugcugcgcgg gcugaaguac      420

auccacucgg ccgggaucau ccaccgggac cugaagccca gcaacguggc ugugaacgag      480

gacugugagc ucaggauccu ggauuucggg cuggcgcgcc aggcggacga ggagaugacc      540

ggcuaugugg ccacgcgcug guaccgggca ccugagauca ugcucaacug gaugcauuac      600

aaccaaacag uggauaucug guccgugggc ugcaucaugg cugagcugcu ccagggcaag      660

gcccucuucc cgggaagcga cuacauugac cagcugaagc gcaucaugga aguggugggc      720

acacccagcc cugagguucu ggcaaaaauc uccucggaac acgcccggac auauauccag      780

ucccugcccc ccaugcccca gaaggaccug agcagcaucu uccguggagc caacccccug      840

gccauagacc uccuuggaag gaugcuggug cuggacagug accagagggu cagugcagcu      900

gaggcacugg cccacgccua cuucagccag uaccacgacc ccgaggauga gccagaggcc      960

gagccauaug augagagcgu ugaggccaag gagcgcacgc uggaggagug gaaggagcuc     1020

acuuaccagg aaguccuuag cuucaagccc ccagagccac cgaagccacc uggcagccug     1080

gagauugagc aguga                                                      1095


<210>  8950
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MK11__Homo_sapiens__AAC12714

<400>  8950
augagcggcc cccgcgccgg guucuaccgg caggagcuga acaagaccgu gugggagguc       60

ccccagcgcc uccagggccu gcggcccgug ggguccggcg ccuacgggag cgugugcucc      120

gcguacgacg cccgccugcg gcagaagguc gccgugaaga agcucagccg ccccuuccag      180

ucccugaucc acgcccggcg caccuaccgg gagcugcgcc uccugaagca ccugaagcac      240

gagaacguga ucggccuccu ggacgucuuc acgcccgcca ccagcaucga ggacuucucc      300

gagguguacc uggugaccac ccucaugggc gcggaccuga acaacaucgu caagugccag      360

gcccugagcg acgagcacgu gcaguuccuc guguaccagc ugcugcgggg gcucaaguac      420

auccacuccg ccggcaucau ccaccgcgac cugaagccga gcaacgucgc cgugaacgag      480

gacugcgagc ugcggauccu cgacuucggg cuggcgcgcc aggccgacga ggagaugacg      540

ggcuacgugg ccacccggug guaccgcgcc cccgagauca ugcugaacug gaugcacuac      600

aaccagaccg ucgacaucug guccgugggg ugcaucaugg ccgagcuccu gcagggcaag      660

gcgcuguucc ccggcagcga cuacaucgac cagcucaagc ggaucaugga gguggucggg      720

acccccuccc cggaggugcu ggccaagauc agcuccgagc acgcccgcac guacauccag      780

agccugccgc ccaugcccca gaaggaccuc uccagcaucu uccggggcgc caacccccug      840

gccaucgacc ugcucgggcg caugcuggug cuggacuccg accagcgggu cagcgcggcc      900

gaggcccucg cccacgccua cuucagccag uaccacgacc ccgaggacga gcccgaggcg      960

gagcccuacg acgaguccgu ggaggccaag gagcgcaccc uggaggagug gaaggagcug     1020

accuaccagg aggugcucag cuucaagccg cccgagccgc ccaagccgcc cggcucccug     1080

gagaucgagc aguga                                                      1095


<210>  8951
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MK11__Homo_sapiens__AAC12714

<400>  8951
auguccggcc cccgcgccgg cuucuaccgc caggagcuca acaagaccgu cugggagguc       60

ccccagcgcc uccagggccu ccgccccguc ggcuccggcg ccuacggcuc cgucugcucc      120

gccuacgacg cccgccuccg ccagaagguc gccgucaaga agcucucccg ccccuuccag      180

ucccucaucc acgcccgccg caccuaccgc gagcuccgcc uccucaagca ccucaagcac      240

gagaacguca ucggccuccu cgacgucuuc acccccgcca ccuccaucga ggacuucucc      300

gaggucuacc ucgucaccac ccucaugggc gccgaccuca acaacaucgu caagugccag      360

gcccucuccg acgagcacgu ccaguuccuc gucuaccagc uccuccgcgg ccucaaguac      420

auccacuccg ccggcaucau ccaccgcgac cucaagcccu ccaacgucgc cgucaacgag      480

gacugcgagc uccgcauccu cgacuucggc cucgcccgcc aggccgacga ggagaugacc      540

ggcuacgucg ccacccgcug guaccgcgcc cccgagauca ugcucaacug gaugcacuac      600

aaccagaccg ucgacaucug guccgucggc ugcaucaugg ccgagcuccu ccagggcaag      660

gcccucuucc ccggcuccga cuacaucgac cagcucaagc gcaucaugga ggucgucggc      720

acccccuccc ccgagguccu cgccaagauc uccuccgagc acgcccgcac cuacauccag      780

ucccuccccc ccaugcccca gaaggaccuc uccuccaucu uccgcggcgc caacccccuc      840

gccaucgacc uccucggccg caugcucguc cucgacuccg accagcgcgu cuccgccgcc      900

gaggcccucg cccacgccua cuucucccag uaccacgacc ccgaggacga gcccgaggcc      960

gagcccuacg acgaguccgu cgaggccaag gagcgcaccc ucgaggagug gaaggagcuc     1020

accuaccagg agguccucuc cuucaagccc cccgagcccc ccaagccccc cggcucccuc     1080

gagaucgagc aguga                                                      1095


<210>  8952
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MK11__Homo_sapiens__AAC12714

<400>  8952
augagcggcc ccagagccgg guucuacagg caggagcuga acaagaccgu gugggaaguc       60

ccucaacggc uccagggacu ucgcccaguu gguuccggcg cuuauggguc ugugugcuca      120

gcauacgacg cccgacugcg ucagaaagua gcggugaaga aauugaguag accguuucag      180

agcuuaaucc acgcuaggcg gacauaucgc gagcugagac uacucaagca ucugaaacac      240

gaaaauguca uuggacuucu ggauguguuc acucccgcca cguccauaga ggacuuuucu      300

gaaguuuacu uggugaccac acucaugggc gcagaucuga acaauaucgu caagugucaa      360

gcccugucgg acgagcaugu gcaguuccuc guauaucagu uacugagggg ucuuaaguac      420

auucacucag cugggaucau ucaucgggau uugaaaccua gcaacguugc agugaaugag      480

gacugcgaac ugcgcauccu agauuuugga cucgcccgac aggcugacga ggaaaugacu      540

ggcuaugucg ccaccagaug guacagggcg ccagagauaa ugcugaacug gaugcacuac      600

aaucaaacag uggauaucug gagugugggc uguauuaugg cagagcuucu gcaggggaag      660

gccuuguucc ccggauccga cuauaucgau cagcucaaac ggauuaugga agucguuggu      720

accccuucuc cagaggugcu ggcuaagauc agcuccgaac acgcccguac uuacauacag      780

ucauuacccc cuaugccaca aaaagaccug aguagcauuu uucgcggcgc aaacccgcuc      840

gcuaucgauc uucuggggag aauguuggua cuagacucug accagagggu guccgccgcg      900

gaggcccugg cacaugcuua uuucucacag uaccacgauc ccgaagacga gccugaggcc      960

gaaccauaug augagagcgu cgaagcuaag gagcggacac ucgaagagug gaaggagcug     1020

accuaccaag aagugcuuag uuuuaaaccc ccugagccac ccaagccgcc uggaucucug     1080

gaaauugagc aguga                                                      1095


<210>  8953
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MK11__Homo_sapiens__AAC12714

<400>  8953
augagcggcc ccagagccgg cuucuacaga caggagcuga acaagaccgu gugggaggug       60

ccccagagac ugcagggccu gagacccgug ggcagcggcg ccuacggcag cgugugcagc      120

gccuacgacg ccagacugag acagaaggug gccgugaaga agcugagcag acccuuccag      180

agccugaucc acgccagaag aaccuacaga gagcugagac ugcugaagca ccugaagcac      240

gagaacguga ucggccugcu ggacguguuc acccccgcca ccagcaucga ggacuucagc      300

gagguguacc uggugaccac ccugaugggc gccgaccuga acaacaucgu gaagugccag      360

gcccugagcg acgagcacgu gcaguuccug guguaccagc ugcugagagg ccugaaguac      420

auccacagcg ccggcaucau ccacagagac cugaagccca gcaacguggc cgugaacgag      480

gacugcgagc ugagaauccu ggacuucggc cuggccagac aggccgacga ggagaugacc      540

ggcuacgugg ccaccagaug guacagagcc cccgagauca ugcugaacug gaugcacuac      600

aaccagaccg uggacaucug gagcgugggc ugcaucaugg ccgagcugcu gcagggcaag      660

gcccuguucc ccggcagcga cuacaucgac cagcugaaga gaaucaugga gguggugggc      720

acccccagcc ccgaggugcu ggccaagauc agcagcgagc acgccagaac cuacauccag      780

agccugcccc ccaugcccca gaaggaccug agcagcaucu ucagaggcgc caacccccug      840

gccaucgacc ugcugggcag aaugcuggug cuggacagcg accagagagu gagcgccgcc      900

gaggcccugg cccacgccua cuucagccag uaccacgacc ccgaggacga gcccgaggcc      960

gagcccuacg acgagagcgu ggaggccaag gagagaaccc uggaggagug gaaggagcug     1020

accuaccagg aggugcugag cuucaagccc cccgagcccc ccaagccccc cggcagccug     1080

gagaucgagc aguga                                                      1095


<210>  8954
<211>  1095
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MK11__Homo_sapiens__AAC12714

<400>  8954
augagcggcc ccagagccgg guucuaccgg caggagcuga acaagaccgu gugggaaguc       60

ccucaacgcc uccagggacu gagaccgguu ggcuccgggg cuuauggauc ugugugcagc      120

gccuacgacg cgcggcuucg ccagaaagug gcugucaaga aacuguccag acccuuucag      180

ucucucaucc acgcccggcg cacauauaga gagcugcggc uucugaagca ucucaaacac      240

gaaaauguga uuggccugcu ggauguuuuc acgccugcca ccagcaucga ggacuuuucc      300

gaaguguacc ucgucacaac ccugaugggg gcugaucuua acaauauugu gaagugucaa      360

gcccugucug acgagcaugu ucaguuccuc guguaucagc ugcuucgcgg acugaaguac      420

auccacagcg cuggcauuau ccauagagau cucaaacccu ccaacgucgc cgugaaugag      480

gacugcgaac ugcggauccu ggauuuuggc cucgcgcgcc aggccgacga ggaaaugaca      540

ggguaugugg cuaccagaug guaccgggcc ccugagauua ugcugaacug gaugcacuac      600

aaucaaacag ucgauaucug gagcguugga uguauuaugg cugagcuucu gcagggcaag      660

gcccucuucc ccgggucuga cuauaucgau cagcugaaac gcauuaugga agugguggga      720

accccuuccc cggagguccu ugcgaagauc agcucugaac acgccagaac guacauucag      780

ucccugcccc cuaugcccca aaaagaccuc agcucuaucu uucggggcgc uaacccucug      840

gccaucgauc ugcucgggag aaugcuggug cuugacuccg accagcgcgu uagcgcugcc      900

gaggcccugg cucaugcgua uuucucccag uaccacgauc ccgaagacga gccggaggcc      960

gaaccuuaug augagucugu ggaagcuaag gagcggaccc ucgaagagug gaaggagcug     1020

acauaccaag aaguccuuag cuuuaaaccc ccugagccuc ccaagccccc gggaucccug     1080

gaaauugagc aguga                                                      1095


<210>  8955
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MK12__Homo_sapiens__P53778

<400>  8955

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    130                 135                 140                 


His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
145                 150                 155                 160 


Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        195                 200                 205             


Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    210                 215                 220                 


Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
225                 230                 235                 240 


Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                245                 250                 255     


Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            260                 265                 270         


Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 
        275                 280                 285             


Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 
    290                 295                 300                 


Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 
                325                 330                 335     


Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 
            340                 345                 350         


Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
        355                 360                 365         


<210>  8956
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MK12__Homo_sapiens__AAH15741

<400>  8956
augagcucuc cgccgcccgc ccgcaguggc uuuuaccgcc aggaggugac caagacggcc       60

ugggaggugc gcgccgugua ccgggaccug cagcccgugg gcucgggcgc cuacggcgcg      120

gugugcucgg ccguggacgg ccgcaccggc gcuaaggugg ccaucaagaa gcuguaucgg      180

cccuuccagu ccgagcuguu cgccaagcgc gccuaccgcg agcugcgccu gcucaagcac      240

augcgccacg agaacgugau cgggcugcug gacguauuca cuccugauga gacccuggau      300

gacuucacgg acuuuuaccu ggugaugccg uucaugggca ccgaccuggg caagcucaug      360

aaacaugaga agcuaggcga ggaccggauc caguuccucg uguaccagau gcugaagggg      420

cugagguaua uccacgcugc cggcaucauc cacagagacc ugaagcccgg caaccuggcu      480

gugaacgaag acugugagcu gaagauccug gacuucggcc uggccaggca ggcagacagu      540

gagaugacug gguacguggu gacccggugg uaccgggcuc ccgaggucau cuugaauugg      600

augcgcuaca cgcagacggu ggacaucugg uccgugggcu gcaucauggc ggagaugauc      660

acaggcaaga cgcuguucaa gggcagcgac caccuggacc agcugaagga gaucaugaag      720

gugacgggga cgccuccggc ugaguuugug cagcggcugc agagcgauga ggccaagaac      780

uacaugaagg gccuccccga auuggagaag aaggauuuug ccucuauccu gaccaaugca      840

agcccucugg cugugaaccu ccuggagaag augcuggugc uggacgcgga gcagcgggug      900

acggcaggcg aggcgcuggc ccaucccuac uucgaguccc ugcacgacac ggaagaugag      960

ccccaggucc agaaguauga ugacuccuuu gacgacguug accgcacacu ggaugaaugg     1020

aagcguguua cuuacaaaga ggugcucagc uucaagccuc cccggcagcu gggggccagg     1080

gucuccaagg agacgccucu guga                                            1104


<210>  8957
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MK12__Homo_sapiens__AAH15741

<400>  8957
augagcagcc cgccgcccgc ccgcuccggc uucuaccggc aggaggugac caagaccgcc       60

ugggaggucc gcgcggugua ccgggaccug cagcccgugg gguccggcgc cuacggggcc      120

gucugcagcg ccguggacgg ccgcaccggg gccaaggugg cgaucaagaa gcucuaccgg      180

cccuuccagu ccgagcuguu cgccaagcgc gccuaccggg agcugcgccu ccugaagcac      240

augcggcacg agaacgucau cggccugcuc gacguguuca cccccgacga gacccuggac      300

gacuucaccg acuucuaccu ggugaugccc uucaugggca cggaccucgg gaagcugaug      360

aagcacgaga agcugggcga ggaccgcauc caguuccucg ucuaccagau gcugaagggg      420

cugcgguaca uccacgccgc gggcaucauc caccgcgacc ucaagcccgg gaaccuggcc      480

gugaacgagg acugcgagcu gaagauccuc gacuucggcc uggcccggca ggccgacagc      540

gagaugaccg gcuacguggu cacccgcugg uaccgggccc ccgaggugau ccugaacugg      600

augcgcuaca cccagacggu ggacaucugg uccgucgggu gcaucauggc ggagaugauc      660

accggcaaga cccucuucaa ggggagcgac caccuggacc agcugaagga gaucaugaag      720

gugaccggca cgccgcccgc cgaguucgug cagcggcucc aguccgacga ggccaagaac      780

uacaugaagg gccugcccga gcuggagaag aaggacuucg ccagcauccu caccaacgcc      840

agcccccugg cggucaaccu gcucgagaag augcuggugc uggacgccga gcagcgcgug      900

accgccgggg aggcccucgc ccacccguac uucgaguccc ugcacgacac cgaggacgag      960

ccccaggucc agaaguacga cgacuccuuc gacgacgugg accggacgcu ggacgagugg     1020

aagcgcguga ccuacaagga gguccucagc uucaagccgc cccggcagcu gggcgcgcgc     1080

guguccaagg agacgccccu guga                                            1104


<210>  8958
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MK12__Homo_sapiens__AAH15741

<400>  8958
auguccuccc ccccccccgc ccgcuccggc uucuaccgcc aggaggucac caagaccgcc       60

ugggaggucc gcgccgucua ccgcgaccuc cagcccgucg gcuccggcgc cuacggcgcc      120

gucugcuccg ccgucgacgg ccgcaccggc gccaaggucg ccaucaagaa gcucuaccgc      180

cccuuccagu ccgagcucuu cgccaagcgc gccuaccgcg agcuccgccu ccucaagcac      240

augcgccacg agaacgucau cggccuccuc gacgucuuca cccccgacga gacccucgac      300

gacuucaccg acuucuaccu cgucaugccc uucaugggca ccgaccucgg caagcucaug      360

aagcacgaga agcucggcga ggaccgcauc caguuccucg ucuaccagau gcucaagggc      420

cuccgcuaca uccacgccgc cggcaucauc caccgcgacc ucaagcccgg caaccucgcc      480

gucaacgagg acugcgagcu caagauccuc gacuucggcc ucgcccgcca ggccgacucc      540

gagaugaccg gcuacgucgu cacccgcugg uaccgcgccc ccgaggucau ccucaacugg      600

augcgcuaca cccagaccgu cgacaucugg uccgucggcu gcaucauggc cgagaugauc      660

accggcaaga cccucuucaa gggcuccgac caccucgacc agcucaagga gaucaugaag      720

gucaccggca ccccccccgc cgaguucguc cagcgccucc aguccgacga ggccaagaac      780

uacaugaagg gccuccccga gcucgagaag aaggacuucg ccuccauccu caccaacgcc      840

uccccccucg ccgucaaccu ccucgagaag augcucgucc ucgacgccga gcagcgcguc      900

accgccggcg aggcccucgc ccaccccuac uucgaguccc uccacgacac cgaggacgag      960

ccccaggucc agaaguacga cgacuccuuc gacgacgucg accgcacccu cgacgagugg     1020

aagcgcguca ccuacaagga gguccucucc uucaagcccc cccgccagcu cggcgcccgc     1080

gucuccaagg agaccccccu cuga                                            1104


<210>  8959
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MK12__Homo_sapiens__AAH15741

<400>  8959
augagcucuc ccccuccagc cagauccggc uucuacaggc aggaggugac caagaccgcu       60

ugggaagucc gggcaguuua ucgcgaccug caaccggugg ggucaggagc cuacggugcg      120

guaugcagug cuguggaugg ccgaacuggg gccaaagucg caaucaagaa acucuaucgu      180

cccuuucaga gcgagcuuuu cgccaagaga gcuuacaggg aacugcgguu guuaaaacac      240

augcgccaug agaacgugau uggacugcua gacguuuuua cgccugauga aacccucgac      300

gauuucacag acuuuuaucu ggugaugcca uucaugggca cugaucuugg uaagcugaug      360

aagcacgaga aauuggggga ggacagaaua caguuucucg ucuaccagau gcugaaggga      420

cugagguaua uccaugcagc cggcauuauc caccgggauc ucaaacccgg caauuuagcu      480

gugaacgaag acugugagcu gaagauucuu gauuucgggu uggcccgcca agcggacucc      540

gaaaugaccg gauacguagu uacacgaugg uacagagcac cugaggugau ccugaauugg      600

augagguaua cccagacugu cgauauaugg ucuguggguu gcaucauggc cgagaugauu      660

acaggcaaaa cccuauuuaa ggggucggac caucucgacc agcugaagga aaucaugaaa      720

gugacgggaa cuccacccgc ugaguucguc cagcggcuuc aaucagauga agccaagaac      780

uacaugaaag gccugccuga guuggaaaag aaagacuuug caagcauucu caccaaugcu      840

aguccacugg ccguuaacuu acuggagaag augcucgugc uugaugcgga gcagcgugua      900

acagccggug aagcacuggc ucacccguau uucgaguccu ugcacgacac ugaagaugag      960

ccccaggugc agaaauacga cgauucuuuu gacgaugucg accgcacccu agaugaaugg     1020

aagagaguga cauauaagga gguucugagc uucaaaccuc caaggcaacu cggggcccgg     1080

guguccaagg agacaccccu guga                                            1104


<210>  8960
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MK12__Homo_sapiens__AAH15741

<400>  8960
augagcagcc ccccccccgc cagaagcggc uucuacagac aggaggugac caagaccgcc       60

ugggagguga gagccgugua cagagaccug cagcccgugg gcagcggcgc cuacggcgcc      120

gugugcagcg ccguggacgg cagaaccggc gccaaggugg ccaucaagaa gcuguacaga      180

cccuuccaga gcgagcuguu cgccaagaga gccuacagag agcugagacu gcugaagcac      240

augagacacg agaacgugau cggccugcug gacguguuca cccccgacga gacccuggac      300

gacuucaccg acuucuaccu ggugaugccc uucaugggca ccgaccuggg caagcugaug      360

aagcacgaga agcugggcga ggacagaauc caguuccugg uguaccagau gcugaagggc      420

cugagauaca uccacgccgc cggcaucauc cacagagacc ugaagcccgg caaccuggcc      480

gugaacgagg acugcgagcu gaagauccug gacuucggcc uggccagaca ggccgacagc      540

gagaugaccg gcuacguggu gaccagaugg uacagagccc ccgaggugau ccugaacugg      600

augagauaca cccagaccgu ggacaucugg agcgugggcu gcaucauggc cgagaugauc      660

accggcaaga cccuguucaa gggcagcgac caccuggacc agcugaagga gaucaugaag      720

gugaccggca ccccccccgc cgaguucgug cagagacugc agagcgacga ggccaagaac      780

uacaugaagg gccugcccga gcuggagaag aaggacuucg ccagcauccu gaccaacgcc      840

agcccccugg ccgugaaccu gcuggagaag augcuggugc uggacgccga gcagagagug      900

accgccggcg aggcccuggc ccaccccuac uucgagagcc ugcacgacac cgaggacgag      960

ccccaggugc agaaguacga cgacagcuuc gacgacgugg acagaacccu ggacgagugg     1020

aagagaguga ccuacaagga ggugcugagc uucaagcccc ccagacagcu gggcgccaga     1080

gugagcaagg agaccccccu guga                                            1104


<210>  8961
<211>  1104
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MK12__Homo_sapiens__AAH15741

<400>  8961
augagcucuc ccccuccggc cagauccggc uucuaccggc aggaggugac caagaccgcu       60

ugggaagucc gcgccguuua uagagaccug caacccgugg ggagcggagc guacggcgcu      120

gugugcuccg ccgucgaugg gcggacggga gccaaagugg cuaucaagaa acucuaucgc      180

ccuuuucagu cugagcuguu cgccaagaga gcuuaccggg aacuucgccu gcucaaacac      240

augagacaug agaacguuau uggccugcuu gacguguuua cccccgauga aacacuggac      300

gauuucaccg acuuuuaucu cgucaugccu uucaugggga cagaucuggg aaagcugaug      360

aagcacgaga aacucggcga ggaccggauc caguuucugg uguaccagau gcuuaagggc      420

cugcgcuaua uucaugccgc ggggaucauu cacagagauc ucaaacccgg aaaucuggcc      480

guuaacgaag acugugagcu uaagauccug gauuucggcc ucgcucggca agccgacagc      540

gaaaugaccg gguacguggu cacacgcugg uacagagcuc cugaggugau ccugaauugg      600

augcgguaua cccagacggu ggauauuugg uccgucggau gcaucauggc cgagaugauu      660

accggcaaaa cacuguuuaa ggggucugac caucucgacc agcugaagga aaucaugaaa      720

guuaccggaa caccgcccgc ggaguucgug cagcgccuuc aaagcgauga agccaagaac      780

uacaugaaag gccugccuga gcucgaaaag aaagacuuug cuuccauucu gaccaaugcc      840

agcccccuug cugugaaccu gcucgagaag augcuggucc uggaugccga gcagagagug      900

acggccggcg aagcucucgc gcacccuuau uucgagucuc ugcacgacac agaagaugag      960

ccccagguuc agaaauacga cgauuccuuu gacgaugugg accggacccu ugaugaaugg     1020

aagagaguca cauauaagga ggugcugagc uucaaaccgc cucgccaacu cggggcccgg     1080

guuucuaagg agacaccccu guga                                            1104


<210>  8962
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MK13__Homo_sapiens__O15264

<400>  8962

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  8963
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MK13__Homo_sapiens__AAB87639

<400>  8963
augagccuca uccggaaaaa gggcuucuac aagcaggacg ucaacaagac agccugggag       60

cugcccaaga ccuacguguc cccgacgcac gucggcagcg gggccuaugg cuccgugugc      120

ucggccaucg acaagcgguc aggggagaag guggccauca agaagcugag ccgacccuuu      180

caguccgaga ucuucgccaa gcgcgccuac cgggagcugc ugcugcugaa gcacaugcag      240

caugagaacg ucauugggcu ccuggauguc uucaccccag ccuccucccu gcgcaacuuc      300

uaugacuucu accuggugau gcccuucaug cagacggauc ugcagaagau cauggggaug      360

gaguucagug aggagaagau ccaguaccug guguaucaga ugcucaaagg ccuuaaguac      420

auccacucug cuggggucgu gcacagggac cugaagccag gcaaccuggc ugugaaugag      480

gacugugaac ugaagauucu ggauuuuggg cuggcgcgac augcagacgc cgagaugacu      540

ggcuacgugg ugacccgcug guaccgagcc cccgagguga uccucagcug gaugcacuac      600

aaccagacag uggacaucug gucugugggc uguaucaugg cagagaugcu gacagggaaa      660

acucuguuca aggggaaaga uuaccuggac cagcugaccc agauccugaa agugaccggg      720

gugccuggca cggaguuugu gcagaagcug aacgacaaag cggccaaauc cuacauccag      780

ucccugccac agacccccag gaaggauuuc acucagcugu ucccacgggc cagcccccag      840

gcugcggacc ugcuggagaa gaugcuggag cuagacgugg acaagcgccu gacggccgcg      900

caggcccuca cccaucccuu uuuugaaccc uuccgggacc cugaggaaga gacggaggcc      960

cagcagccgu uugaugauuc cuuagaacac gagaaacuca caguggauga auggaagcag     1020

cacaucuaca aggagauugu gaacuucagc cccauugccc ggaaggacuc acggcgccgg     1080

aguggcauga agcuguag                                                   1098


<210>  8964
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MK13__Homo_sapiens__AAB87639

<400>  8964
augagccuga uccgcaagaa gggcuucuac aagcaggacg ugaacaagac cgccugggag       60

cuccccaaga ccuacgucuc cccgacgcac guggggagcg gcgccuacgg guccgugugc      120

agcgcgaucg acaagcgguc cggcgagaag gucgccauca agaagcugag ccgccccuuc      180

caguccgaga ucuucgccaa gcgggccuac cgcgagcugc uccugcugaa gcacaugcag      240

cacgagaacg ugaucgggcu ccuggacgug uucacccccg ccagcucccu gcggaacuuc      300

uacgacuucu accucgucau gcccuucaug cagaccgacc ugcagaagau caugggcaug      360

gaguucagcg aggagaagau ccaguaccug guguaccaga ugcucaaggg ccugaaguac      420

auccacuccg cggggguggu ccaccgcgac cugaagccgg gcaaccucgc cgugaacgag      480

gacugcgagc ugaagauccu ggacuucggg cucgcccggc acgccgacgc ggagaugacc      540

ggcuacgugg ucacgcgcug guaccgggcc cccgagguga uccugagcug gaugcacuac      600

aaccagaccg uggacaucug guccgucggg ugcaucaugg ccgagaugcu gaccggcaag      660

acccucuuca agggcaagga cuaccuggac cagcugacgc agauccucaa ggugaccggg      720

gugcccggca ccgaguucgu ccagaagcug aacgacaagg ccgccaagag cuacauccag      780

ucccugcccc agaccccgcg caaggacuuc acgcagcugu ucccccgggc gagcccccag      840

gccgccgacc uccuggagaa gaugcucgag cuggacgugg acaagcgccu gaccgccgcc      900

caggcgcuca cccaccccuu cuucgagccg uuccgggacc ccgaggagga gaccgaggcc      960

cagcagcccu ucgacgacuc ccuggagcac gagaagcuga cgguggacga guggaagcag     1020

cacaucuaca aggagaucgu caacuucagc cccaucgccc gcaaggacuc ccggcgccgg     1080

agcgggauga agcucuga                                                   1098


<210>  8965
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MK13__Homo_sapiens__AAB87639

<400>  8965
augucccuca uccgcaagaa gggcuucuac aagcaggacg ucaacaagac cgccugggag       60

cuccccaaga ccuacgucuc ccccacccac gucggcuccg gcgccuacgg cuccgucugc      120

uccgccaucg acaagcgcuc cggcgagaag gucgccauca agaagcucuc ccgccccuuc      180

caguccgaga ucuucgccaa gcgcgccuac cgcgagcucc uccuccucaa gcacaugcag      240

cacgagaacg ucaucggccu ccucgacguc uucacccccg ccuccucccu ccgcaacuuc      300

uacgacuucu accucgucau gcccuucaug cagaccgacc uccagaagau caugggcaug      360

gaguucuccg aggagaagau ccaguaccuc gucuaccaga ugcucaaggg ccucaaguac      420

auccacuccg ccggcgucgu ccaccgcgac cucaagcccg gcaaccucgc cgucaacgag      480

gacugcgagc ucaagauccu cgacuucggc cucgcccgcc acgccgacgc cgagaugacc      540

ggcuacgucg ucacccgcug guaccgcgcc cccgagguca uccucuccug gaugcacuac      600

aaccagaccg ucgacaucug guccgucggc ugcaucaugg ccgagaugcu caccggcaag      660

acccucuuca agggcaagga cuaccucgac cagcucaccc agauccucaa ggucaccggc      720

guccccggca ccgaguucgu ccagaagcuc aacgacaagg ccgccaaguc cuacauccag      780

ucccuccccc agaccccccg caaggacuuc acccagcucu ucccccgcgc cuccccccag      840

gccgccgacc uccucgagaa gaugcucgag cucgacgucg acaagcgccu caccgccgcc      900

caggcccuca cccaccccuu cuucgagccc uuccgcgacc ccgaggagga gaccgaggcc      960

cagcagcccu ucgacgacuc ccucgagcac gagaagcuca ccgucgacga guggaagcag     1020

cacaucuaca aggagaucgu caacuucucc cccaucgccc gcaaggacuc ccgccgccgc     1080

uccggcauga agcucuga                                                   1098


<210>  8966
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MK13__Homo_sapiens__AAB87639

<400>  8966
augagccuga ucagaaagaa aggcuucuac aagcaggacg ugaacaaaac cgccugggag       60

cuccccaaga cauaugucuc cccuacucac guugggucug gagcuuacgg uucagugugc      120

agugcaauug auaaaaggag cggcgaaaag guagccauaa agaaacuuuc ccggccauuu      180

caaucugaga ucuucgcgaa gcgcgcuuau cgagaacugu uguuacugaa acauaugcag      240

cacgagaaug ugauugggcu acucgacguc uuuacgccgg ccucgucacu gcguaacuuc      300

uacgauuuuu aucuugugau gcccuucaug cagaccgacc ugcagaagau caugggaaug      360

gaauuuagcg aggagaaaau ucaauacuug guuuaucaga ugcucaaggg ccugaaguac      420

auccauagug ccgguguggu ccacagagau cugaaaccug ggaaucucgc agugaacgaa      480

gacugugagu uaaagauacu ggauuucgga cuugcuaggc augcagacgc cgaaaugaca      540

ggcuacguag uuacucggug guaucgcgcu ccagagguga ucuuguccug gaugcacuac      600

aaucagaccg ucgauauuug gucugugggc ugcaucaugg ccgagaugcu gacagggaaa      660

acccuauuua agggaaaaga cuaucucgau cagcugacuc aaauucuuaa ggugacaggu      720

guccccggca ccgaguucgu ucagaaacug aacgacaagg cggcaaagag cuacauccag      780

uccuugccuc agacgccaag aaaagauuuu acucaacucu uccccagggc cucaccucag      840

gcugccgacc uguuagaaaa gaugcuggaa cucgacgugg auaaacggcu uaccgcagcu      900

caggcccuga cacacccauu uuucgagccg uuccgcgacc ccgaagagga gacugaagcg      960

caacagccuu uugaugacag uuuggagcau gaaaagcuaa ccguagauga guggaaacag     1020

cacauauaua aggaaauugu gaauuucagc ccaaucgccc gaaaggacuc uagaaggcgg     1080

uccgggauga aacuguga                                                   1098


<210>  8967
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MK13__Homo_sapiens__AAB87639

<400>  8967
augagccuga ucagaaagaa gggcuucuac aagcaggacg ugaacaagac cgccugggag       60

cugcccaaga ccuacgugag ccccacccac gugggcagcg gcgccuacgg cagcgugugc      120

agcgccaucg acaagagaag cggcgagaag guggccauca agaagcugag cagacccuuc      180

cagagcgaga ucuucgccaa gagagccuac agagagcugc ugcugcugaa gcacaugcag      240

cacgagaacg ugaucggccu gcuggacgug uucacccccg ccagcagccu gagaaacuuc      300

uacgacuucu accuggugau gcccuucaug cagaccgacc ugcagaagau caugggcaug      360

gaguucagcg aggagaagau ccaguaccug guguaccaga ugcugaaggg ccugaaguac      420

auccacagcg ccggcguggu gcacagagac cugaagcccg gcaaccuggc cgugaacgag      480

gacugcgagc ugaagauccu ggacuucggc cuggccagac acgccgacgc cgagaugacc      540

ggcuacgugg ugaccagaug guacagagcc cccgagguga uccugagcug gaugcacuac      600

aaccagaccg uggacaucug gagcgugggc ugcaucaugg ccgagaugcu gaccggcaag      660

acccuguuca agggcaagga cuaccuggac cagcugaccc agauccugaa ggugaccggc      720

gugcccggca ccgaguucgu gcagaagcug aacgacaagg ccgccaagag cuacauccag      780

agccugcccc agacccccag aaaggacuuc acccagcugu uccccagagc cagcccccag      840

gccgccgacc ugcuggagaa gaugcuggag cuggacgugg acaagagacu gaccgccgcc      900

caggcccuga cccaccccuu cuucgagccc uucagagacc ccgaggagga gaccgaggcc      960

cagcagcccu ucgacgacag ccuggagcac gagaagcuga ccguggacga guggaagcag     1020

cacaucuaca aggagaucgu gaacuucagc cccaucgcca gaaaggacag cagaagaaga     1080

agcggcauga agcuguga                                                   1098


<210>  8968
<211>  1098
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MK13__Homo_sapiens__AAB87639

<400>  8968
augagccuga ucagaaagaa aggcuucuac aagcaggacg ugaacaaaac cgccugggag       60

cuccccaaga cauaugucuc cccuacgcac guugggucug gagcuuacgg cagcgugugc      120

uccgccauug auaaacgguc uggggaaaag guggcgauca agaaacugag ccgcccguuu      180

caauccgaga uuuucgcuaa gagagccuau cgggaacuuc ugcuccugaa acauaugcag      240

cacgagaaug ucaucggacu ucuggacgug uuuacccccg ccucuagccu ccgcaacuuc      300

uacgauuuuu aucugguuau gccuuucaug cagacagacc ugcagaagau uaugggcaug      360

gaauuuuccg aggagaaaau ccaauaccuc guguaucaga ugcugaaggg gcuuaaguac      420

auccauagcg cuggagucgu gcacagagau cugaaacccg gcaaucucgc cguuaacgaa      480

gacugugagc ugaagauucu ugauuucggc cuggcucggc augccgacgc ggaaaugacc      540

ggguacgugg ucacacgcug guauagagcc ccugagguga uccucucuug gaugcacuac      600

aaucagaccg uggauauuug guccgucgga ugcaucaugg cugagaugcu gacaggcaaa      660

acccuguuua aggggaaaga cuaucucgau cagcugacgc aaauucuuaa gguuaccgga      720

gugcccggca cagaguucgu gcagaaacug aacgacaagg ccgcuaagag cuacauccag      780

ucucucccuc agaccccgcg gaaagauuuu acacaacugu ucccccgcgc cuccccucag      840

gcggccgacc uucuggaaaa gaugcucgaa cuggacgucg auaaaagacu gaccgcugcc      900

caggcucuca cgcaccccuu uuucgagccu uuccgggacc ccgaagagga gacagaagcc      960

caacagccgu uugaugacag ccuggagcau gaaaaacuua ccguggauga guggaagcag     1020

cacauuuaua aggaaaucgu uaauuucucu ccuaucgccc gcaaggacuc cagacggcgc     1080

agcgggauga aacuguga                                                   1098


<210>  8969
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MK14__Homo_sapiens__Q16539

<400>  8969

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  8970
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MK14__Homo_sapiens__AAA57456

<400>  8970
augucucagg agaggcccac guucuaccgg caggagcuga acaagacaau cugggaggug       60

cccgagcguu accagaaccu gucuccagug ggcucuggcg ccuauggcuc ugugugugcu      120

gcuuuugaca caaaaacggg guuacgugug gcagugaaga agcucuccag accauuucag      180

uccaucauuc augcgaaaag aaccuacaga gaacugcggu uacuuaaaca uaugaaacau      240

gaaaauguga uuggucuguu ggacguuuuu acaccugcaa ggucucugga ggaauucaau      300

gauguguauc uggugaccca ucucaugggg gcagaucuga acaacauugu gaaaugucag      360

aagcuuacag augaccaugu ucaguuccuu aucuaccaaa uucuccgagg ucuaaaguau      420

auacauucag cugacauaau ucacagggac cuaaaaccua guaaucuagc ugugaaugaa      480

gacugugagc ugaagauucu ggauuuugga cuggcucggc acacagauga ugaaaugaca      540

ggcuacgugg ccacuaggug guacagggcu ccugagauca ugcugaacug gaugcauuac      600

aaccagacag uugauauuug gucaguggga ugcauaaugg ccgagcuguu gacuggaaga      660

acauuguuuc cugguacaga ccauauugau caguugaagc ucauuuuaag acucguugga      720

accccagggg cugagcuuuu gaagaaaauc uccucagagu cugcaagaaa cuauauucag      780

ucuuugacuc agaugccgaa gaugaacuuu gcgaauguau uuauuggugc caauccccug      840

gcugucgacu ugcuggagaa gaugcuugua uuggacucag auaagagaau uacagcggcc      900

caagcccuug cacaugccua cuuugcucag uaccacgauc cugaugauga accaguggcc      960

gauccuuaug aucaguccuu ugaaagcagg gaccuccuua uagaugagug gaaaagccug     1020

accuaugaug aagucaucag cuuugugcca ccaccccuug accaagaaga gauggagucc     1080

uga                                                                   1083


<210>  8971
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MK14__Homo_sapiens__AAA57456

<400>  8971
augagccagg agcgccccac cuucuaccgg caggagcuga acaagaccau cugggaggug       60

cccgagcgcu accagaaccu cucccccguc ggcagcgggg ccuacggcuc cgugugcgcc      120

gcguucgaca cgaagaccgg gcugcgggug gccgucaaga agcugagccg ccccuuccag      180

uccaucaucc acgccaagcg gaccuaccgc gagcuccggc ugcugaagca caugaagcac      240

gagaacguga ucggccuccu ggacguguuc acccccgccc gcagccugga ggaguucaac      300

gacgucuacc ucgugacgca ccugaugggg gccgaccuga acaacaucgu gaagugccag      360

aagcucaccg acgaccacgu ccaguuccug aucuaccaga uccugcgggg ccucaaguac      420

auccacuccg cggacaucau ccaccgcgac cugaagccga gcaaccuggc cgugaacgag      480

gacugcgagc ucaagauccu ggacuucggc cuggcccggc acaccgacga cgagaugacc      540

ggguacgugg ccacgcgcug guaccgggcg cccgagauca ugcucaacug gaugcacuac      600

aaccagaccg ucgacaucug guccgugggc ugcaucaugg ccgagcugcu gaccgggcgc      660

acccucuucc ccggcacgga ccacaucgac cagcugaagc ugauccuccg gcuggugggg      720

acccccggcg ccgagcugcu caagaagauc agcuccgaga gcgcccgcaa cuacauccag      780

ucccugaccc agaugccgaa gaugaacuuc gccaacgucu ucaucggcgc gaacccccug      840

gccguggacc uccuggagaa gaugcuggug cucgacagcg acaagcggau caccgccgcc      900

caggcccugg cgcacgccua cuucgcccag uaccacgacc ccgacgacga gcccgucgcc      960

gacccguacg accaguccuu cgagagccgc gaccugcuca ucgacgagug gaagucccug     1020

acguacgacg aggugaucag cuucgugccc ccgccccugg accaggagga gauggagucc     1080

uga                                                                   1083


<210>  8972
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MK14__Homo_sapiens__AAA57456

<400>  8972
augucccagg agcgccccac cuucuaccgc caggagcuca acaagaccau cugggagguc       60

cccgagcgcu accagaaccu cucccccguc ggcuccggcg ccuacggcuc cgucugcgcc      120

gccuucgaca ccaagaccgg ccuccgcguc gccgucaaga agcucucccg ccccuuccag      180

uccaucaucc acgccaagcg caccuaccgc gagcuccgcc uccucaagca caugaagcac      240

gagaacguca ucggccuccu cgacgucuuc acccccgccc gcucccucga ggaguucaac      300

gacgucuacc ucgucaccca ccucaugggc gccgaccuca acaacaucgu caagugccag      360

aagcucaccg acgaccacgu ccaguuccuc aucuaccaga uccuccgcgg ccucaaguac      420

auccacuccg ccgacaucau ccaccgcgac cucaagcccu ccaaccucgc cgucaacgag      480

gacugcgagc ucaagauccu cgacuucggc cucgcccgcc acaccgacga cgagaugacc      540

ggcuacgucg ccacccgcug guaccgcgcc cccgagauca ugcucaacug gaugcacuac      600

aaccagaccg ucgacaucug guccgucggc ugcaucaugg ccgagcuccu caccggccgc      660

acccucuucc ccggcaccga ccacaucgac cagcucaagc ucauccuccg ccucgucggc      720

acccccggcg ccgagcuccu caagaagauc uccuccgagu ccgcccgcaa cuacauccag      780

ucccucaccc agaugcccaa gaugaacuuc gccaacgucu ucaucggcgc caacccccuc      840

gccgucgacc uccucgagaa gaugcucguc cucgacuccg acaagcgcau caccgccgcc      900

caggcccucg cccacgccua cuucgcccag uaccacgacc ccgacgacga gcccgucgcc      960

gaccccuacg accaguccuu cgagucccgc gaccuccuca ucgacgagug gaagucccuc     1020

accuacgacg aggucaucuc cuucgucccc cccccccucg accaggagga gauggagucc     1080

uga                                                                   1083


<210>  8973
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MK14__Homo_sapiens__AAA57456

<400>  8973
augagccagg agagacccac cuucuacagg caagaacuga acaagacaau augggaggug       60

ccugaacggu aucagaaucu cuccccaguc ggcucugggg ccuacggauc aguuugcgcu      120

gcauuugaca cuaaaacggg ucuucgcgug gccguaaaga aacugagucg accguuccag      180

agcauuauac acgcgaagcg uaccuauaga gaguugaggu uacugaaaca uaugaagcac      240

gaaaacguga ucggccuacu cgaugucuuu acacccgcuc ggucccugga ggaguucaau      300

gacguguacc uuguuacuca ucugaugggg gccgauuuga acaauauugu gaagugucag      360

aaacucaccg acgaucacgu ccaauuucug aucuaucaga uucugcgcgg acucaaguac      420

auccauucug cagacauaau ccacagagau uuaaaaccuu cgaaccuggc cgugaaugaa      480

gacugcgagc uuaagauuuu ggauuucggc cuggcuaggc acacagacga ugaaaugacc      540

gguuauguag caacucggug guaccgcgcc ccagagauca ugcuaaacug gaugcauuac      600

aaucagacag uugacauuug gucagugggg uguaucaugg cugagcuccu gaccggacga      660

acgcuuuuuc ccggcacuga ucacauagac cagcugaaau ugauucucag acuggucggc      720

accccugggg ccgaauuacu gaagaagauc agcagugagu ccgcgaggaa cuauauucaa      780

ucucucacac agaugccaaa aaugaauuuc gcaaacgugu uuaucggagc caauccccuu      840

gcuguggacc uguuggaaaa gaugcuaguc cuggauagcg acaaacggau cacugccgca      900

caggcucucg cccaugcgua cuucgcccag uaucacgauc cugacgauga gccaguugca      960

gacccguacg aucaauccuu ugaaucacgu gaccugcuua uugaugagug gaagagucug     1020

accuaugacg aggugaucag cuucguaccc ccuccauugg aucaggaaga gauggaaucu     1080

uga                                                                   1083


<210>  8974
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MK14__Homo_sapiens__AAA57456

<400>  8974
augagccagg agagacccac cuucuacaga caggagcuga acaagaccau cugggaggug       60

cccgagagau accagaaccu gagccccgug ggcagcggcg ccuacggcag cgugugcgcc      120

gccuucgaca ccaagaccgg ccugagagug gccgugaaga agcugagcag acccuuccag      180

agcaucaucc acgccaagag aaccuacaga gagcugagac ugcugaagca caugaagcac      240

gagaacguga ucggccugcu ggacguguuc acccccgcca gaagccugga ggaguucaac      300

gacguguacc uggugaccca ccugaugggc gccgaccuga acaacaucgu gaagugccag      360

aagcugaccg acgaccacgu gcaguuccug aucuaccaga uccugagagg ccugaaguac      420

auccacagcg ccgacaucau ccacagagac cugaagccca gcaaccuggc cgugaacgag      480

gacugcgagc ugaagauccu ggacuucggc cuggccagac acaccgacga cgagaugacc      540

ggcuacgugg ccaccagaug guacagagcc cccgagauca ugcugaacug gaugcacuac      600

aaccagaccg uggacaucug gagcgugggc ugcaucaugg ccgagcugcu gaccggcaga      660

acccuguucc ccggcaccga ccacaucgac cagcugaagc ugauccugag acuggugggc      720

acccccggcg ccgagcugcu gaagaagauc agcagcgaga gcgccagaaa cuacauccag      780

agccugaccc agaugcccaa gaugaacuuc gccaacgugu ucaucggcgc caacccccug      840

gccguggacc ugcuggagaa gaugcuggug cuggacagcg acaagagaau caccgccgcc      900

caggcccugg cccacgccua cuucgcccag uaccacgacc ccgacgacga gcccguggcc      960

gaccccuacg accagagcuu cgagagcaga gaccugcuga ucgacgagug gaagagccug     1020

accuacgacg aggugaucag cuucgugccc cccccccugg accaggagga gauggagagc     1080

uga                                                                   1083


<210>  8975
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MK14__Homo_sapiens__AAA57456

<400>  8975
augagccagg agagacccac cuucuaccgg caagaacuga acaagacaau cugggaggug       60

ccugaacgcu aucagaaucu cuccccgguc ggcucugggg ccuacggaag cguuugcgcu      120

gccuuugaca cgaagaccgg ccugagagug gcggugaaga aacuuucccg gcccuuccag      180

ucuauuaucc acgcuaagcg cacauauaga gagcugcggc uccugaaaca uaugaagcac      240

gaaaacguca uugggcuucu ggauguguuu accccugccc gcagccucga ggaguucaau      300

gacguuuacc uggugacaca ucugauggga gccgaucuca acaauaucgu caagugucag      360

aaacugaccg acgaucacgu gcaauuucuu auuuaucaga uccugagagg ccucaaguac      420

auccauuccg cugacauuau ccaccgggau cugaaacccu cuaaccuugc cguuaaugaa      480

gacugcgagc ugaagauucu cgauuucggg cuggcucgcc acacagacga ugaaaugacc      540

ggauaugugg ccacgagaug guaccgggcg ccugagauca ugcugaacug gaugcauuac      600

aaucagaccg ucgacauuug gagcgugggc uguaucaugg ccgagcuccu gacaggccgc      660

acccuuuuuc ccgggacaga ucacauugac cagcugaaac ucauccugag acuuguggga      720

accccuggcg cugaacugcu caagaagauc uccagcgagu cugcccggaa cuauauucaa      780

ucccugacgc agaugccgaa aaugaauuuc gcuaacgucu uuaucggggc caauccccug      840

gcgguugacc uccuggaaaa gaugcuugug cuggauagcg acaaacgcau uacagccgcu      900

caggcccucg cucaugccua cuucgcccag uaucacgauc cugacgauga gcccguggcu      960

gacccuuacg aucaaucuuu ugaauccaga gaccugcuua ucgaugagug gaaaagccug     1020

accuaugacg aggucauuuc uuucgugccc ccgccucucg aucaggaaga gauggaaucc     1080

uga                                                                   1083


<210>  8976
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MKK1__Homo_sapiens__Q02750

<400>  8976

Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp 
1               5                   10                  15      


Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala 
            20                  25                  30          


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys 
        35                  40                  45              


Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys 
    50                  55                  60                  


Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly 
65                  70                  75                  80  


Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg 
                85                  90                  95      


Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile 
            100                 105                 110         


Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly 
        115                 120                 125             


Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu 
    130                 135                 140                 


His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg 
145                 150                 155                 160 


Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly 
                165                 170                 175     


Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp 
        195                 200                 205             


Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr 
225                 230                 235                 240 


Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met 
                245                 250                 255     


Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu 
            260                 265                 270         


Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro 
        275                 280                 285             


Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser 
    290                 295                 300                 


Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu 
305                 310                 315                 320 


Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp 
                325                 330                 335     


Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu 
            340                 345                 350         


Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu 
        355                 360                 365             


Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro 
    370                 375                 380                 


Ser Thr Pro Thr His Ala Ala Gly Val 
385                 390             


<210>  8977
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MKK1__Homo_sapiens__AAA36318

<400>  8977
augcccaaga agaagccgac gcccauccag cugaacccgg cccccgacgg cucugcaguu       60

aacgggacca gcucugcgga gaccaacuug gaggccuugc agaagaagcu ggaggagcua      120

gagcuugaug agcagcagcg aaagcgccuu gaggccuuuc uuacccagaa gcagaaggug      180

ggagaacuga aggaugacga cuuugagaag aucagugagc ugggggcugg caauggcggu      240

gugguguuca aggucuccca caagccuucu ggccugguca uggccagaaa gcuaauucau      300

cuggagauca aacccgcaau ccggaaccag aucauaaggg agcugcaggu ucugcaugag      360

ugcaacucuc cguacaucgu gggcuucuau ggugcguucu acagcgaugg cgagaucagu      420

aucugcaugg agcacaugga uggagguucu cuggaucaag uccugaagaa agcuggaaga      480

auuccugaac aaauuuuagg aaaaguuagc auugcuguaa uaaaaggccu gacauaucug      540

agggagaagc acaagaucau gcacagagau gucaagcccu ccaacauccu agucaacucc      600

cguggggaga ucaagcucug ugacuuuggg gucagcgggc agcucaucga cuccauggcc      660

aacuccuucg ugggcacaag guccuacaug ucgccagaaa gacuccaggg gacucauuac      720

ucugugcagu cagacaucug gagcauggga cugucucugg uagagauggc gguugggagg      780

uaucccaucc cuccuccaga ugccaaggag cuggagcuga uguuugggug ccagguggaa      840

ggagaugcgg cugagacccc acccaggcca aggacccccg ggaggccccu uagcucauac      900

ggaauggaca gccgaccucc cauggcaauu uuugaguugu uggauuacau agucaacgag      960

ccuccuccaa aacugcccag uggaguguuc agucuggaau uucaagauuu ugugaauaaa     1020

ugcuuaauaa aaaaccccgc agagagagca gauuugaagc aacucauggu ucaugcuuuu     1080

aucaagagau cugaugcuga ggaaguggau uuugcagguu ggcucugcuc caccaucggc     1140

cuuaaccagc ccagcacacc aacccaugcu gcuggcgucu aa                        1182


<210>  8978
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MKK1__Homo_sapiens__AAA36318

<400>  8978
augcccaaga agaagcccac ccccauccag cugaaccccg cccccgacgg cagcgccgug       60

aacgggaccu ccagcgcgga gacgaaccuc gaggcccugc agaagaagcu ggaggagcuc      120

gagcuggacg agcagcagcg caagcggcug gaggccuucc ucacccagaa gcagaagguc      180

ggcgagcuga aggacgacga cuucgagaag aucuccgagc ugggggccgg caacgggggc      240

gugguguuca aggucagcca caagccgucc ggccucguga uggcccgcaa gcugauccac      300

cuggagauca agcccgcgau ccggaaccag aucauccgcg agcuccaggu gcugcacgag      360

ugcaacagcc ccuacaucgu cggguucuac ggcgccuucu acuccgacgg ggagaucagc      420

aucugcaugg agcacaugga cggcgggucc cuggaccagg ugcucaagaa ggccggccgg      480

auccccgagc agauccuggg caaggugagc aucgccguca ucaaggggcu gaccuaccuc      540

cgcgagaagc acaagaucau gcaccgggac gugaagccgu ccaacauccu ggugaacagc      600

cgcggcgaga ucaagcugug cgacuucggg gucuccggcc agcucaucga cagcauggcg      660

aacuccuucg ugggcacccg gagcuacaug ucccccgagc gccugcaggg gacgcacuac      720

agcgugcagu ccgacaucug gagcaugggc cugagccucg ucgagauggc cguggggcgg      780

uaccccaucc cgccgcccga cgccaaggag cuggagcuga uguucggcug ccagguggag      840

ggggacgccg ccgagacccc gccccgcccc cggacccccg gccgcccccu cuccagcuac      900

ggcauggacu cccggccgcc cauggcgauc uucgagcugc uggacuacau cgucaacgag      960

cccccgccca agcuccccag cgggguguuc ucccuggagu uccaggacuu cgugaacaag     1020

ugccugauca agaaccccgc cgagcgcgcc gaccucaagc agcugauggu ccacgccuuc     1080

aucaagcgga gcgacgccga ggagguggac uucgcgggcu ggcugugcuc caccaucggg     1140

cucaaccagc ccagcacgcc cacccacgcc gccggcgugu ga                        1182


<210>  8979
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MKK1__Homo_sapiens__AAA36318

<400>  8979
augcccaaga agaagcccac ccccauccag cucaaccccg cccccgacgg cuccgccguc       60

aacggcaccu ccuccgccga gaccaaccuc gaggcccucc agaagaagcu cgaggagcuc      120

gagcucgacg agcagcagcg caagcgccuc gaggccuucc ucacccagaa gcagaagguc      180

ggcgagcuca aggacgacga cuucgagaag aucuccgagc ucggcgccgg caacggcggc      240

gucgucuuca aggucuccca caagcccucc ggccucguca uggcccgcaa gcucauccac      300

cucgagauca agcccgccau ccgcaaccag aucauccgcg agcuccaggu ccuccacgag      360

ugcaacuccc ccuacaucgu cggcuucuac ggcgccuucu acuccgacgg cgagaucucc      420

aucugcaugg agcacaugga cggcggcucc cucgaccagg uccucaagaa ggccggccgc      480

auccccgagc agauccucgg caaggucucc aucgccguca ucaagggccu caccuaccuc      540

cgcgagaagc acaagaucau gcaccgcgac gucaagcccu ccaacauccu cgucaacucc      600

cgcggcgaga ucaagcucug cgacuucggc gucuccggcc agcucaucga cuccauggcc      660

aacuccuucg ucggcacccg cuccuacaug ucccccgagc gccuccaggg cacccacuac      720

uccguccagu ccgacaucug guccaugggc cucucccucg ucgagauggc cgucggccgc      780

uaccccaucc ccccccccga cgccaaggag cucgagcuca uguucggcug ccaggucgag      840

ggcgacgccg ccgagacccc cccccgcccc cgcacccccg gccgcccccu cuccuccuac      900

ggcauggacu cccgcccccc cauggccauc uucgagcucc ucgacuacau cgucaacgag      960

ccccccccca agcuccccuc cggcgucuuc ucccucgagu uccaggacuu cgucaacaag     1020

ugccucauca agaaccccgc cgagcgcgcc gaccucaagc agcucauggu ccacgccuuc     1080

aucaagcgcu ccgacgccga ggaggucgac uucgccggcu ggcucugcuc caccaucggc     1140

cucaaccagc ccuccacccc cacccacgcc gccggcgucu ga                        1182


<210>  8980
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MKK1__Homo_sapiens__AAA36318

<400>  8980
augcccaaga aaaagccuac cccaauccag cugaacccgg cccccgacgg cagcgcugug       60

aaugggacau ccucugcaga gacuaaccuc gaagcccuuc agaaaaagcu ggaggaauug      120

gaguuagaug aacaacagag aaaaaggcug gaggcguucc uaacgcagaa gcaaaagguc      180

ggagagcuca aagacgauga cuuugaaaag auuucagagc ugggugcugg caauggggga      240

guuguguuca aaguaaguca caagccuagc ggccuuguga uggcccggaa acugauacau      300

uuggaaauca agccagcaau ucgcaaccag aucauucgag agcuccaggu ccugcacgag      360

ugcaauuccc ccuacaucgu ggguuuuuau ggggccuucu acucugaugg agaaauaucg      420

aucuguaugg agcauaugga cggcggcuca cuggaucagg uucucaagaa agcugggcgu      480

auuccugaac aaaucuuagg aaaggugagc auugcaguca ucaaaggucu gaccuaucuu      540

agagagaagc acaaaauaau gcauagggac gugaagccaa guaacauuuu gguaaauucc      600

cggggcgaaa ucaaacugug cgauuuuggg guuucuggac agcuaauuga cagcauggcc      660

aacuccuucg ugggcacacg cucauacaug agucccgaga gacuccaggg uacucacuau      720

agcguccagu cugauaucug guccaugggg cugucacuug uggagauggc ugugggaagg      780

uacccuaucc caccgcccga cgccaaggaa cuggaguuga uguuuggcug ucaagucgaa      840

ggcgaugcgg cagagacccc uccacggccc cgcacaccug ggcgaccacu cagcaguuau      900

ggaauggacu cuagaccccc gauggccauu uucgaacugu uagacuacau aguuaaugag      960

ccucccccaa agcugccuuc cgguguguuu agccucgagu uccaggauuu uguaaacaaa     1020

ugccuuauca agaaucccgc ugaaagggcc gaccugaaac aguugauggu gcacgcauuc     1080

auuaagcggu cggaugcuga ggaagucgac uuugccggcu ggcuauguuc uaccaucggg     1140

cugaaccaac cauccacucc cacacaugcg gccggagugu ga                        1182


<210>  8981
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MKK1__Homo_sapiens__AAA36318

<400>  8981
augcccaaga agaagcccac ccccauccag cugaaccccg cccccgacgg cagcgccgug       60

aacggcacca gcagcgccga gaccaaccug gaggcccugc agaagaagcu ggaggagcug      120

gagcuggacg agcagcagag aaagagacug gaggccuucc ugacccagaa gcagaaggug      180

ggcgagcuga aggacgacga cuucgagaag aucagcgagc ugggcgccgg caacggcggc      240

gugguguuca aggugagcca caagcccagc ggccugguga uggccagaaa gcugauccac      300

cuggagauca agcccgccau cagaaaccag aucaucagag agcugcaggu gcugcacgag      360

ugcaacagcc ccuacaucgu gggcuucuac ggcgccuucu acagcgacgg cgagaucagc      420

aucugcaugg agcacaugga cggcggcagc cuggaccagg ugcugaagaa ggccggcaga      480

auccccgagc agauccuggg caaggugagc aucgccguga ucaagggccu gaccuaccug      540

agagagaagc acaagaucau gcacagagac gugaagccca gcaacauccu ggugaacagc      600

agaggcgaga ucaagcugug cgacuucggc gugagcggcc agcugaucga cagcauggcc      660

aacagcuucg ugggcaccag aagcuacaug agccccgaga gacugcaggg cacccacuac      720

agcgugcaga gcgacaucug gagcaugggc cugagccugg uggagauggc cgugggcaga      780

uaccccaucc ccccccccga cgccaaggag cuggagcuga uguucggcug ccagguggag      840

ggcgacgccg ccgagacccc ccccagaccc agaacccccg gcagaccccu gagcagcuac      900

ggcauggaca gcagaccccc cauggccauc uucgagcugc uggacuacau cgugaacgag      960

ccccccccca agcugcccag cggcguguuc agccuggagu uccaggacuu cgugaacaag     1020

ugccugauca agaaccccgc cgagagagcc gaccugaagc agcugauggu gcacgccuuc     1080

aucaagagaa gcgacgccga ggagguggac uucgccggcu ggcugugcag caccaucggc     1140

cugaaccagc ccagcacccc cacccacgcc gccggcgugu ga                        1182


<210>  8982
<211>  1182
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MKK1__Homo_sapiens__AAA36318

<400>  8982
augcccaaga aaaagccuac cccgauccag cugaaccccg ccccugacgg cagcgcugug       60

aaugggacau ccucugccga gacgaaccuc gaagcgcugc aaaagaaacu ugaggaacug      120

gagcucgaug aacagcagag aaaacggcug gaggcuuucc uuacccagaa gcaaaagguc      180

ggagagcuga aagacgauga cuuugaaaag auuagcgagc ucggcgccgg gaauggaggc      240

guuguguuca aaguguccca caagcccucu gggcugguca uggcccgcaa acugauccau      300

cucgaaauua agccugcuau cagaaaccag auuauccggg agcuucaggu gcugcacgag      360

ugcaauagcc ccuacaucgu uggauuuuau ggcgccuucu acuccgaugg cgaaauuucu      420

aucuguaugg agcauaugga cgggggaagc cuggaucagg ugcucaagaa agcuggccgc      480

auuccugaac aaauccuggg gaaggucucc auugccguga ucaaaggacu uacauaucug      540

agagagaagc acaaaauuau gcaucgggac guuaagccga gcaacauccu cgucaauucu      600

cgcggcgaaa ucaaacugug cgauuuuggg guguccggac agcugauuga cagcauggcg      660

aacucuuucg ugggcaccag auccuacaug agccccgagc ggcuccaggg cacacacuau      720

ucugugcagu ccgauaucug gagcaugggg cugucccuug ucgagauggc cguuggacgc      780

uacccuauuc ccccucccga cgcuaaggaa cuggagcuca uguuuggcug ucaaguggaa      840

ggggaugccg cugagacccc gccuagaccc cggacaccug gacgcccccu gucuagcuau      900

ggcauggacu ccagaccccc uauggccauc uucgaacuuc uggacuacau ugugaaugag      960

ccgcccccua agcuccccag cggggucuuu ucucuggagu uccaggauuu ugugaacaaa     1020

ugccugauca agaauccugc ggaacgggcc gaccucaaac agcugauggu ucacgcuuuc     1080

aucaagcgcu ccgaugccga ggaaguggac uuugcuggau ggcuuuguag caccauuggc     1140

cugaaccaac ccucuacgcc gacccaugcc gccggcgucu ga                        1182


<210>  8983
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MKK3__Homo_sapiens__P46734

<400>  8983

Met Glu Ser Pro Ala Ser Ser Gln Pro Ala Ser Met Pro Gln Ser Lys 
1               5                   10                  15      


Gly Lys Ser Lys Arg Lys Lys Asp Leu Arg Ile Ser Cys Met Ser Lys 
            20                  25                  30          


Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp Ser Arg Thr 
        35                  40                  45              


Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala Asp Asp Leu 
    50                  55                  60                  


Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys 
65                  70                  75                  80  


Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys Arg Ile Arg 
                85                  90                  95      


Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp 
            100                 105                 110         


Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr Phe Tyr Gly 
        115                 120                 125             


Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu Leu Met Asp 
    130                 135                 140                 


Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys Asn Met Thr 
145                 150                 155                 160 


Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile Val Arg Ala 
                165                 170                 175     


Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys 
            180                 185                 190         


Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys Met Cys Asp 
        195                 200                 205             


Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met Asp 
    210                 215                 220                 


Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu 
225                 230                 235                 240 


Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser Leu Gly Ile 
                245                 250                 255     


Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu Ser Trp Gly 
            260                 265                 270         


Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln 
        275                 280                 285             


Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe Thr Ala Gln 
    290                 295                 300                 


Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu Glu Leu Met 
305                 310                 315                 320 


Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr Asp Ile Ala 
                325                 330                 335     


Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser 
            340                 345         


<210>  8984
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MKK3__Homo_sapiens__AAH32478

<400>  8984
auggagucgc ccgccucgag ccagcccgcc agcaugcccc aguccaaagg aaaauccaag       60

aggaagaagg aucuacggau auccugcaug uccaagccac ccgcacccaa ccccacaccc      120

ccccggaacc uggacucccg gaccuucauc accauuggag acagaaacuu ugagguggag      180

gcugaugacu uggugaccau cucagaacug ggccguggag ccuauggggu gguagagaag      240

gugcggcacg cccagagcgg caccaucaug gccgugaagc ggauccgggc caccgugaac      300

ucacaggagc agaagcggcu gcucauggac cuggacauca acaugcgcac ggucgacugc      360

uucuacacug ucaccuucua cggggcacua uucagagagg gagacgugug gaucugcaug      420

gagcucaugg acacauccuu ggacaaguuc uaccggaagg ugcuggauaa aaacaugaca      480

auuccagagg acauccuugg ggagauugcu gugucuaucg ugcgggcccu ggagcaucug      540

cacagcaagc ugucggugau ccacagagau gugaagcccu ccaauguccu uaucaacaag      600

gagggccaug ugaagaugug ugacuuuggc aucaguggcu acuuggugga cucuguggcc      660

aagacgaugg augccggcug caagcccuac auggccccug agaggaucaa cccagagcug      720

aaccagaagg gcuacaaugu caaguccgac gucuggagcc ugggcaucac caugauugag      780

auggccaucc ugcgguuccc uuacgagucc ugggggaccc cguuccagca gcugaagcag      840

gugguggagg agccgucccc ccagcuccca gccgaccguu ucucccccga guuuguggac      900

uucacugcuc agugccugag gaagaacccc gcagagcgua ugagcuaccu ggagcugaug      960

gagcaccccu ucuucaccuu gcacaaaacc aagaagacgg acauugcugc cuucgugaag     1020

gagauccugg gagaagacuc auag                                            1044


<210>  8985
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MKK3__Homo_sapiens__AAH32478

<400>  8985
auggagagcc ccgccuccag ccagccggcc uccaugcccc agagcaaggg caaguccaag       60

cgcaagaagg accugcggau cagcugcaug uccaagccgc ccgcgcccaa ccccaccccg      120

ccccgcaacc ucgacagccg gaccuucauc acgaucgggg accgcaacuu cgagguggag      180

gccgacgacc uggucaccau cuccgagcug ggccgcgggg ccuacggcgu gguggagaag      240

guccggcacg cccagagcgg gaccaucaug gccgugaagc ggauccgcgc gaccgugaac      300

ucccaggagc agaagcggcu ccugauggac cuggacauca acaugcgcac ggucgacugc      360

uucuacaccg ugaccuucua cggcgcccuc uuccgggagg gcgacgugug gaucugcaug      420

gagcugaugg acaccagccu ggacaaguuc uaccgcaagg uccucgacaa gaacaugacg      480

auccccgagg acauccuggg ggagaucgcc guguccaucg ugcgggcccu ggagcaccuc      540

cacagcaagc uguccgucau ccaccgcgac gugaagccca gcaacgugcu gaucaacaag      600

gagggccacg ucaagaugug cgacuucggg aucuccggcu accucgugga cagcguggcg      660

aagaccaugg acgccgggug caagcccuac auggcccccg agcggaucaa cccggagcug      720

aaccagaagg gcuacaacgu caaguccgac guguggagcc ugggcaucac caugaucgag      780

auggccaucc uccgcuuccc cuacgagagc ugggggaccc ccuuccagca gcugaagcag      840

gucguggagg agcccucccc gcagcugccc gccgaccggu ucagccccga guucguggac      900

uucacggcgc agugccuccg caagaacccc gccgagcgga uguccuaccu ggagcugaug      960

gagcacccgu ucuucacccu ccacaagacc aagaagaccg acaucgccgc cuucgugaag     1020

gagauccugg gcgaggacag cuga                                            1044


<210>  8986
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MKK3__Homo_sapiens__AAH32478

<400>  8986
auggaguccc ccgccuccuc ccagcccgcc uccaugcccc aguccaaggg caaguccaag       60

cgcaagaagg accuccgcau cuccugcaug uccaagcccc ccgcccccaa ccccaccccc      120

ccccgcaacc ucgacucccg caccuucauc accaucggcg accgcaacuu cgaggucgag      180

gccgacgacc ucgucaccau cuccgagcuc ggccgcggcg ccuacggcgu cgucgagaag      240

guccgccacg cccaguccgg caccaucaug gccgucaagc gcauccgcgc caccgucaac      300

ucccaggagc agaagcgccu ccucauggac cucgacauca acaugcgcac cgucgacugc      360

uucuacaccg ucaccuucua cggcgcccuc uuccgcgagg gcgacgucug gaucugcaug      420

gagcucaugg acaccucccu cgacaaguuc uaccgcaagg uccucgacaa gaacaugacc      480

auccccgagg acauccucgg cgagaucgcc gucuccaucg uccgcgcccu cgagcaccuc      540

cacuccaagc ucuccgucau ccaccgcgac gucaagcccu ccaacguccu caucaacaag      600

gagggccacg ucaagaugug cgacuucggc aucuccggcu accucgucga cuccgucgcc      660

aagaccaugg acgccggcug caagcccuac auggcccccg agcgcaucaa ccccgagcuc      720

aaccagaagg gcuacaacgu caaguccgac gucugguccc ucggcaucac caugaucgag      780

auggccaucc uccgcuuccc cuacgagucc uggggcaccc ccuuccagca gcucaagcag      840

gucgucgagg agcccucccc ccagcucccc gccgaccgcu ucucccccga guucgucgac      900

uucaccgccc agugccuccg caagaacccc gccgagcgca uguccuaccu cgagcucaug      960

gagcaccccu ucuucacccu ccacaagacc aagaagaccg acaucgccgc cuucgucaag     1020

gagauccucg gcgaggacuc cuga                                            1044


<210>  8987
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MKK3__Homo_sapiens__AAH32478

<400>  8987
auggagagcc ccgccuccuc ucagccugcu ucaaugccac aaaguaaggg caaaagcaag       60

aggaaaaagg accugagaau cuccugcaug ucuaaaccgc ccgcaccuaa cccaacaccc      120

ccucggaauc ucgauucgcg caccuucauu acuauagggg accgaaacuu ugaaguggag      180

gccgaugacc uugucacgau cucagaacug ggacguggug cguacggcgu uguggagaag      240

guaagacacg cucagagcgg gaccauuaug gccgugaaga ggauccgggc aacagucaau      300

agucaggaac agaaacgcuu guuaauggau cuggacauua acaugagaac uguggauugu      360

uucuauaccg uuacauuuua cggagcccua uucagggagg gcgacgugug gaucugcaug      420

gagcucaugg auaccucccu ggacaaguuu uaucggaaag uccuugauaa gaauaugacu      480

auaccagaag acauccuggg ugagauugcu gugucuaucg uacgcgcauu ggaacaucuc      540

cacagcaaac uguccguuau ucaucgagau gugaagcccu caaacguccu gaucaauaag      600

gaggggcacg ugaaaaugug ugacuucgga auaaguggcu accucgugga cagcgucgcc      660

aagacaaugg augcuggcug caaaccuuau auggccccag agagaauuaa cccggaauua      720

aaucaaaagg gguacaacgu uaaaucugac gugugguccc ugggaaucac caugauugag      780

auggcgaucc uuagguuucc cuaugaauca ugggguacgc cuuuccagca guugaagcag      840

guaguggagg aaccaagccc ccaacugccu gcagaucggu uuaguccaga guucgucgac      900

uuuacugccc agugucuacg uaaaaauccc gcugagcgca ugucuuaccu cgaacugaug      960

gagcauccgu ucuuuacccu ucacaagaca aagaaaacug auaucgccgc auucgugaag     1020

gaaauucugg gcgaggacuc cuga                                            1044


<210>  8988
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MKK3__Homo_sapiens__AAH32478

<400>  8988
auggagagcc ccgccagcag ccagcccgcc agcaugcccc agagcaaggg caagagcaag       60

agaaagaagg accugagaau cagcugcaug agcaagcccc ccgcccccaa ccccaccccc      120

cccagaaacc uggacagcag aaccuucauc accaucggcg acagaaacuu cgagguggag      180

gccgacgacc uggugaccau cagcgagcug ggcagaggcg ccuacggcgu gguggagaag      240

gugagacacg cccagagcgg caccaucaug gccgugaaga gaaucagagc caccgugaac      300

agccaggagc agaagagacu gcugauggac cuggacauca acaugagaac cguggacugc      360

uucuacaccg ugaccuucua cggcgcccug uucagagagg gcgacgugug gaucugcaug      420

gagcugaugg acaccagccu ggacaaguuc uacagaaagg ugcuggacaa gaacaugacc      480

auccccgagg acauccuggg cgagaucgcc gugagcaucg ugagagcccu ggagcaccug      540

cacagcaagc ugagcgugau ccacagagac gugaagccca gcaacgugcu gaucaacaag      600

gagggccacg ugaagaugug cgacuucggc aucagcggcu accuggugga cagcguggcc      660

aagaccaugg acgccggcug caagcccuac auggcccccg agagaaucaa ccccgagcug      720

aaccagaagg gcuacaacgu gaagagcgac guguggagcc ugggcaucac caugaucgag      780

auggccaucc ugagauuccc cuacgagagc uggggcaccc ccuuccagca gcugaagcag      840

gugguggagg agcccagccc ccagcugccc gccgacagau ucagccccga guucguggac      900

uucaccgccc agugccugag aaagaacccc gccgagagaa ugagcuaccu ggagcugaug      960

gagcaccccu ucuucacccu gcacaagacc aagaagaccg acaucgccgc cuucgugaag     1020

gagauccugg gcgaggacag cuga                                            1044


<210>  8989
<211>  1044
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MKK3__Homo_sapiens__AAH32478

<400>  8989
auggagagcc ccgccuccuc ucagccugcu agcaugccgc aauccaaggg caaaucuaag       60

agaaagaagg accugcggau cagcugcaug uccaaacccc cugcccccaa cccuacaccc      120

ccucgcaauc ucgauucuag aaccuucauu acgaucgggg accggaacuu ugaaguggag      180

gcggaugacc uggucaccau uagcgaacuu ggacgcggcg cuuacggggu uguggagaag      240

gugagacacg cccaguccgg aacaaucaug gccgucaagc ggauucgcgc uaccgugaau      300

agccaggaac agaaaagacu gcucauggau cuggacauca acaugcggac aguugauugu      360

uucuauaccg ugacauuuua cggcgcccuu uuccgcgagg gggacgucug gaucugcaug      420

gagcugaugg auaccucucu cgacaaguuu uauagaaaag ugcuggauaa gaauaugacg      480

auuccggaag acauccuggg agagauugcu guuuccaucg ugcgggcccu cgaacaucug      540

cacagcaaac uuucugucau ucaucgcgau gugaagcccu ccaacgugcu gaucaauaag      600

gagggccacg ucaaaaugug ugacuucggc auuagcgggu accucguuga cucuguggcg      660

aagaccaugg augccggaug caaaccuuau auggcucccg agagaaucaa cccugaacug      720

aaucaaaagg gcuacaacgu gaaauccgac gucuggagcc uugggaucac aaugauugag      780

auggccaucc ugcgguuucc cuaugaaucc uggggaaccc cguuccagca gcucaaacag      840

gugguugagg aaccuucucc ccaacugccu gcugaucgcu uuagccccga guucguggac      900

uuuacagccc agugucugcg gaaaaauccc gcggagagaa uguccuaccu cgaacugaug      960

gagcauccuu ucuuuacccu ucacaagacg aagaaaacag auauugccgc uuucgucaag     1020

gaaauccugg gcgaggacag cuga                                            1044


<210>  8990
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MKK4__Homo_sapiens__P45985

<400>  8990

Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210>  8991
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MKK4__Homo_sapiens__AAC24130

<400>  8991
auggcggcuc cgagcccgag cggcggcggc ggcuccgggg gcggcagcgg cagcggcacc       60

cccggccccg uagggucccc ggcgccaggc cacccggccg ucagcagcau gcaggguaaa      120

cgcaaagcac ugaaguugaa uuuugcaaau ccaccuuuca aaucuacagc aagguuuacu      180

cugaauccca auccuacagg aguucaaaac ccacacauag agagacugag aacacacagc      240

auugagucau caggaaaacu gaagaucucc ccugaacaac acugggauuu cacugcagag      300

gacuugaaag accuuggaga aauuggacga ggagcuuaug guucugucaa caaaaugguc      360

cacaaaccaa gugggcaaau aauggcaguu aaaagaauuc ggucaacagu ggaugaaaaa      420

gaacaaaaac aacuucuuau ggauuuggau guaguaaugc ggaguaguga uugcccauac      480

auuguucagu uuuauggugc acucuucaga gagggugacu guuggaucug uauggaacuc      540

augucuaccu cguuugauaa guuuuacaaa uauguauaua guguauuaga ugauguuauu      600

ccagaagaaa uuuuaggcaa aaucacuuua gcaacuguga aagcacuaaa ccacuuaaaa      660

gaaaacuuga aaauuauuca cagagauauc aaaccuucca auauucuucu ggacagaagu      720

ggaaauauua agcucuguga cuucggcauc aguggacagc uuguggacuc uauugccaag      780

acaagagaug cuggcuguag gccauacaug gcaccugaaa gaauagaccc aagcgcauca      840

cgacaaggau augauguccg cucugauguc uggaguuugg ggaucacauu guaugaguug      900

gccacaggcc gauuuccuua uccaaagugg aauaguguau uugaucaacu aacacaaguc      960

gugaaaggag auccuccgca gcugaguaau ucugaggaaa gggaauucuc cccgaguuuc     1020

aucaacuuug ucaacuugug ccuuacgaag gaugaaucca aaaggccaaa guauaaagag     1080

cuucugaaac aucccuuuau uuugauguau gaagaacgug ccguugaggu cgcaugcuau     1140

guuuguaaaa uccuggauca aaugccagcu acucccagcu cucccaugua ugucgauuga     1200


<210>  8992
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MKK4__Homo_sapiens__AAC24130

<400>  8992
auggccgccc ccagcccguc cggcgggggc gggagcggcg ggggcuccgg cagcgggacc       60

cccggccccg uggggucccc cgcgccgggc caccccgccg ucagcuccau gcaggggaag      120

cgcaaggccc ugaagcucaa cuucgccaac ccgcccuuca agagcaccgc ccgguucacg      180

cugaacccca accccaccgg cgugcagaac ccccacaucg agcgccugcg gacccacucc      240

aucgagagcu ccggcaagcu caagaucagc cccgagcagc acugggacuu caccgcggag      300

gaccugaagg accuggggga gaucggccgc ggggccuacg gcuccgugaa caagaugguc      360

cacaagccga gcggccagau cauggccgug aagcggaucc gcuccacggu ggacgagaag      420

gagcagaagc agcuccugau ggaccuggac gucgugaugc ggagcuccga cugccccuac      480

aucgugcagu ucuacggggc ccucuuccgc gagggcgacu gcuggaucug cauggagcug      540

augagcaccu ccuucgacaa guucuacaag uacgucuaca gcgugcugga cgacgugauc      600

cccgaggaga uccucgggaa gaucacccug gcgaccguca aggcccugaa ccaccucaag      660

gagaaccuga agaucaucca ccgggacauc aagcccagca acauccugcu cgaccgcucc      720

ggcaacauca agcugugcga cuucgggauc agcggccagc ugguggacuc caucgccaag      780

acgcgggacg ccggcugccg cccguacaug gcccccgagc ggaucgaccc cagcgcgucc      840

cgccaggggu acgacgugcg gagcgacguc uggucccucg gcaucacccu guacgagcug      900

gccaccgggc gcuuccccua cccgaagugg aacagcgugu ucgaccagcu cacccaggug      960

gucaagggcg acccgcccca gcuguccaac agcgaggagc gggaguucuc ccccagcuuc     1020

aucaacuucg ugaaccugug ccucacgaag gacgagucca agcgccccaa guacaaggag     1080

cugcugaagc accccuucau ccucauguac gaggagcggg ccguggaggu cgccugcuac     1140

gugugcaaga uccuggacca gaugcccgcc acccccagcu ccccgaugua cguggacuga     1200


<210>  8993
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MKK4__Homo_sapiens__AAC24130

<400>  8993
auggccgccc ccucccccuc cggcggcggc ggcuccggcg gcggcuccgg cuccggcacc       60

cccggccccg ucggcucccc cgcccccggc caccccgccg ucuccuccau gcagggcaag      120

cgcaaggccc ucaagcucaa cuucgccaac ccccccuuca aguccaccgc ccgcuucacc      180

cucaacccca accccaccgg cguccagaac ccccacaucg agcgccuccg cacccacucc      240

aucgaguccu ccggcaagcu caagaucucc cccgagcagc acugggacuu caccgccgag      300

gaccucaagg accucggcga gaucggccgc ggcgccuacg gcuccgucaa caagaugguc      360

cacaagcccu ccggccagau cauggccguc aagcgcaucc gcuccaccgu cgacgagaag      420

gagcagaagc agcuccucau ggaccucgac gucgucaugc gcuccuccga cugccccuac      480

aucguccagu ucuacggcgc ccucuuccgc gagggcgacu gcuggaucug cauggagcuc      540

auguccaccu ccuucgacaa guucuacaag uacgucuacu ccguccucga cgacgucauc      600

cccgaggaga uccucggcaa gaucacccuc gccaccguca aggcccucaa ccaccucaag      660

gagaaccuca agaucaucca ccgcgacauc aagcccucca acauccuccu cgaccgcucc      720

ggcaacauca agcucugcga cuucggcauc uccggccagc ucgucgacuc caucgccaag      780

acccgcgacg ccggcugccg ccccuacaug gcccccgagc gcaucgaccc cuccgccucc      840

cgccagggcu acgacguccg cuccgacguc uggucccucg gcaucacccu cuacgagcuc      900

gccaccggcc gcuuccccua ccccaagugg aacuccgucu ucgaccagcu cacccagguc      960

gucaagggcg acccccccca gcucuccaac uccgaggagc gcgaguucuc ccccuccuuc     1020

aucaacuucg ucaaccucug ccucaccaag gacgagucca agcgccccaa guacaaggag     1080

cuccucaagc accccuucau ccucauguac gaggagcgcg ccgucgaggu cgccugcuac     1140

gucugcaaga uccucgacca gaugcccgcc acccccuccu cccccaugua cgucgacuga     1200


<210>  8994
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MKK4__Homo_sapiens__AAC24130

<400>  8994
auggccgcuc ccagcccuuc cggcggggga gguucuggcg ggggaucagg cagugguacc       60

ccagggccgg ugggaagccc cgcaccuggc cacccagccg ucuccucuau gcagggcaag      120

agaaaagcgc ugaagcucaa cuucgcuaau cccccuuuua aaucgacagc cagguucacu      180

cuuaacccaa aucccacggg gguucaaaac ccucauaucg agcggcugcg cacccacuca      240

auugaaagca guggaaaguu gaaaauaucc ccagagcagc auugggacuu uacagcagaa      300

gauuuaaagg accuggguga gaucggccga ggggccuacg gaucugugaa uaagauggua      360

cacaaaccga gcggccagau uauggcugug aagcguauca gauccacugu cgaugaaaaa      420

gagcagaagc aacuacucau ggaccuggau gugguuauga ggucaaguga cugccccuau      480

auugugcagu ucuacggugc acuuuuucgg gagggggauu guuggaucug cauggaacug      540

augagcaccu cuuucgacaa auuuuauaag uacgucuauu ccguguugga ugacguaaua      600

ccugaggaaa uccucggaaa gauuacacug gccaccguua aagcucugaa ccaucucaag      660

gagaauuuaa aaaucauuca ccgcgauauc aagccaucaa acauacugcu ugacagaagc      720

ggcaauauua aauuguguga uuucggcauc agugggcagc ugguggacuc uauugccaag      780

acuagggacg cgggaugccg gcccuacaug gcaccugagc gcaucgaucc auccgccagc      840

cgacaggguu augacgucag aucggaugug uggucucuag gcaucacacu cuacgaacug      900

gcuaccggga gguuucccua cccgaaaugg aacuccgugu ucgaccaacu uacgcagguc      960

guuaagggag auccucccca gcugucaaau agugaggaac gggaguuuag cccauccuuc     1020

auuaacuuug ugaauuugug ucucacuaag gacgaaucua aacguccuaa guauaaagag     1080

cuguuaaagc accccuucau acugauguac gaggaacgcg ccguagaggu ggcaugcuau     1140

gucuguaaaa uccucgauca gaugccagcu acccccagcu caccuaugua cguggacuga     1200


<210>  8995
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MKK4__Homo_sapiens__AAC24130

<400>  8995
auggccgccc ccagccccag cggcggcggc ggcagcggcg gcggcagcgg cagcggcacc       60

cccggccccg ugggcagccc cgcccccggc caccccgccg ugagcagcau gcagggcaag      120

agaaaggccc ugaagcugaa cuucgccaac ccccccuuca agagcaccgc cagauucacc      180

cugaacccca accccaccgg cgugcagaac ccccacaucg agagacugag aacccacagc      240

aucgagagca gcggcaagcu gaagaucagc cccgagcagc acugggacuu caccgccgag      300

gaccugaagg accugggcga gaucggcaga ggcgccuacg gcagcgugaa caagauggug      360

cacaagccca gcggccagau cauggccgug aagagaauca gaagcaccgu ggacgagaag      420

gagcagaagc agcugcugau ggaccuggac guggugauga gaagcagcga cugccccuac      480

aucgugcagu ucuacggcgc ccuguucaga gagggcgacu gcuggaucug cauggagcug      540

augagcacca gcuucgacaa guucuacaag uacguguaca gcgugcugga cgacgugauc      600

cccgaggaga uccugggcaa gaucacccug gccaccguga aggcccugaa ccaccugaag      660

gagaaccuga agaucaucca cagagacauc aagcccagca acauccugcu ggacagaagc      720

ggcaacauca agcugugcga cuucggcauc agcggccagc ugguggacag caucgccaag      780

accagagacg ccggcugcag acccuacaug gcccccgaga gaaucgaccc cagcgccagc      840

agacagggcu acgacgugag aagcgacgug uggagccugg gcaucacccu guacgagcug      900

gccaccggca gauuccccua ccccaagugg aacagcgugu ucgaccagcu gacccaggug      960

gugaagggcg acccccccca gcugagcaac agcgaggaga gagaguucag ccccagcuuc     1020

aucaacuucg ugaaccugug ccugaccaag gacgagagca agagacccaa guacaaggag     1080

cugcugaagc accccuucau ccugauguac gaggagagag ccguggaggu ggccugcuac     1140

gugugcaaga uccuggacca gaugcccgcc acccccagca gccccaugua cguggacuga     1200


<210>  8996
<211>  1200
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MKK4__Homo_sapiens__AAC24130

<400>  8996
auggccgcuc ccagcccuuc cggcggggga ggcucugggg gaggcagcgg guccggaacc       60

ccgggccccg ugggcucucc ugcccccggg cacccugcgg ucagcuccau gcagggaaag      120

agaaaagcuc ugaagcucaa cuucgccaau cccccuuuua aaucuacagc ccgguucacg      180

cugaacccga aucccaccgg cguucaaaac ccucauaucg agcgccuuag aacacacagc      240

auugaaucca gcgggaagcu gaaaaucucu cccgagcagc auugggacuu uaccgcugaa      300

gaucucaagg accugggaga gauuggccgc ggggccuacg gauccgugaa uaagauggug      360

cacaaaccua gcggccagau cauggcuguc aagcggauua gaucuacagu ggaugaaaaa      420

gagcagaagc aacuucugau ggaccucgau guugugaugc gguccagcga cugccccuau      480

aucguccagu ucuacggcgc ccuguuucgc gagggggauu guuggaucug cauggaacug      540

augucuaccu ccuucgacaa auuuuauaag uacguguaua gcguucucga ugacgugauu      600

ccggaggaaa uccugggaaa gauuacacuu gcgaccguca aagcccugaa ccaucucaag      660

gagaaucuga aaaucauuca cagagauauc aagccuucca acauucuucu ggaccggucu      720

ggcaauauca aacucuguga uuucgggauc agcggacagc ugguggacuc cauugcuaag      780

acgcgcgacg ccggcugcag acccuacaug gcuccugagc ggaucgaucc cagcgccucu      840

cgccaggggu augacgugag auccgauguc uggagccugg gaauuacccu cuacgaacug      900

gcgacaggcc gguuucccua cccuaaaugg aacucuguuu ucgaccaacu uacccaggug      960

gugaagggcg auccgcccca gcugagcaau uccgaggaac gcgaguuuuc uccuagcuuc     1020

aucaacuuug ucaaucucug ucugacaaag gacgaaucca aaagacccaa guauaaagag     1080

cuucugaagc acccuuucau ucucauguac gaggaacggg ccguggaggu ugcuugcuau     1140

guguguaaaa uccuggauca gaugcccgcc accccgagcu cuccuaugua cgucgacuga     1200


<210>  8997
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MKK6__Homo_sapiens__P52564

<400>  8997

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
1               5                   10                  15      


Lys Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
            20                  25                  30          


Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
        35                  40                  45              


Lys Ala Asp Asp Leu Glu Pro Ile Met Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
    130                 135                 140                 


Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Ala Leu Gly Gln 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
    290                 295                 300                 


Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Leu His Glu Ser Lys 
305                 310                 315                 320 


Gly Thr Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                325                 330                 


<210>  8998
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MKK6__Homo_sapiens__AAB05035

<400>  8998
augucucagu cgaaaggcaa gaagcgaaac ccuggccuua aaauuccaaa agaagcauuu       60

gaacaaccuc agaccaguuc cacaccaccu cgagauuuag acuccaaggc uugcauuucu      120

auuggaaauc agaacuuuga ggugaaggca gaugaccugg agccuauaau ggaacuggga      180

cgaggugcgu acgggguggu ggagaagaug cggcacgugc ccagcgggca gaucauggca      240

gugaagcgga uccgagccac aguaaauagc caggaacaga aacggcuacu gauggauuug      300

gauauuucca ugaggacggu ggacugucca uucacuguca ccuuuuaugg cgcacuguuu      360

cgggagggug auguguggau cugcauggag cucauggaua caucacuaga uaaauucuac      420

aaacaaguua uugauaaagg ccagacaauu ccagaggaca ucuuagggaa aauagcaguu      480

ucuauuguaa aagcauuaga acauuuacau aguaagcugu cugucauuca cagagacguc      540

aagccuucua auguacucau caaugcucuc ggucaaguga agaugugcga uuuuggaauc      600

aguggcuacu ugguggacuc uguugcuaaa acaauugaug cagguugcaa accauacaug      660

gccccugaaa gaauaaaccc agagcucaac cagaagggau acagugugaa gucugacauu      720

uggagucugg gcaucacgau gauugaguug gccauccuuc gauuucccua ugauucaugg      780

ggaacuccau uucagcagcu caaacaggug guagaggagc caucgccaca acucccagca      840

gacaaguucu cugcagaguu uguugacuuu accucacagu gcuuaaagaa gaauuccaaa      900

gaacggccua cauacccaga gcuaaugcaa cauccauuuu ucacccuaca ugaauccaaa      960

ggaacagaug uggcaucuuu uguaaaacug auucuuggag acuaa                     1005


<210>  8999
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MKK6__Homo_sapiens__AAB05035

<400>  8999
augagccagu ccaagggcaa gaagcgcaac cccgggcuga agaucccgaa ggaggccuuc       60

gagcagcccc agaccagcuc caccccgccc cgggaccucg acagcaaggc cugcaucucc      120

aucggcaacc agaacuucga ggugaaggcg gacgaccugg agcccaucau ggagcugggg      180

cgcggcgccu acggggucgu ggagaagaug cggcacgugc ccagcggcca gaucauggcc      240

gucaagcgca uccgggccac ggugaacucc caggagcaga agcgccuccu gauggaccug      300

gacaucagca ugcggaccgu ggacugcccc uucaccguca ccuucuacgg cgcccucuuc      360

cgcgaggggg acguguggau cugcauggag cugauggaca cgucccugga caaguucuac      420

aagcagguca ucgacaaggg ccagaccauc cccgaggaca uccucgggaa gaucgcggug      480

agcaucguga aggcccugga gcaccuccac uccaagcuga gcgugaucca ccgggacguc      540

aagccgucca acgugcugau caacgcccug ggccagguga agaugugcga cuucgggauc      600

agcggcuacc ucgucgacuc cguggccaag accaucgacg cgggcugcaa gcccuacaug      660

gcccccgagc gcaucaaccc cgagcugaac cagaaggggu acagcgugaa guccgacauc      720

uggagccugg gcaucaccau gaucgagcuc gccauccugc gguucccgua cgacuccugg      780

gggacgcccu uccagcagcu gaagcagguc guggaggagc ccagccccca gcucccggcc      840

gacaaguuca gcgccgaguu cguggacuuc accucccagu gccugaagaa gaacagcaag      900

gagcgcccca ccuaccccga gcugaugcag caccccuucu ucacccucca cgaguccaag      960

ggcacggacg ucgcgagcuu cgugaagcug auccugggcg acuga                     1005


<210>  9000
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MKK6__Homo_sapiens__AAB05035

<400>  9000
augucccagu ccaagggcaa gaagcgcaac cccggccuca agauccccaa ggaggccuuc       60

gagcagcccc agaccuccuc cacccccccc cgcgaccucg acuccaaggc cugcaucucc      120

aucggcaacc agaacuucga ggucaaggcc gacgaccucg agcccaucau ggagcucggc      180

cgcggcgccu acggcgucgu cgagaagaug cgccacgucc ccuccggcca gaucauggcc      240

gucaagcgca uccgcgccac cgucaacucc caggagcaga agcgccuccu cauggaccuc      300

gacaucucca ugcgcaccgu cgacugcccc uucaccguca ccuucuacgg cgcccucuuc      360

cgcgagggcg acgucuggau cugcauggag cucauggaca ccucccucga caaguucuac      420

aagcagguca ucgacaaggg ccagaccauc cccgaggaca uccucggcaa gaucgccguc      480

uccaucguca aggcccucga gcaccuccac uccaagcucu ccgucaucca ccgcgacguc      540

aagcccucca acguccucau caacgcccuc ggccagguca agaugugcga cuucggcauc      600

uccggcuacc ucgucgacuc cgucgccaag accaucgacg ccggcugcaa gcccuacaug      660

gcccccgagc gcaucaaccc cgagcucaac cagaagggcu acuccgucaa guccgacauc      720

uggucccucg gcaucaccau gaucgagcuc gccauccucc gcuuccccua cgacuccugg      780

ggcacccccu uccagcagcu caagcagguc gucgaggagc ccucccccca gcuccccgcc      840

gacaaguucu ccgccgaguu cgucgacuuc accucccagu gccucaagaa gaacuccaag      900

gagcgcccca ccuaccccga gcucaugcag caccccuucu ucacccucca cgaguccaag      960

ggcaccgacg ucgccuccuu cgucaagcuc auccucggcg acuga                     1005


<210>  9001
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MKK6__Homo_sapiens__AAB05035

<400>  9001
augagccagu ccaagggcaa aaagagaaac cccgggcuga aaaucccuaa ggaggccuuc       60

gaacaaccac agaccucuuc aacaccgccc agggaccucg auaguaaggc uugcauuagc      120

auaggaaauc agaacuuuga ggugaaggca gacgaucuug aaccuaucau ggagcugggu      180

cggggcgccu acggggucgu ugaaaagaug cgccacgugc cauccggaca gauuauggcg      240

guaaaacgaa uccgugcuac ugucaauucu caagagcaga agagauuguu aauggaccug      300

gauauuucga ugaggacggu ggacuguccc uucaccguga cauuuuaugg cgcccuauuc      360

cgggagggug auguuuggau cugcauggaa cucauggaca cuucacugga uaaauuuuac      420

aaacagguga uagacaaagg gcagaccauc ccugaggaua uucuuggaaa gaucgcaguc      480

agcauuguga aggcccugga acauuugcac aguaaacucu ccguaaucca ucgcgacguu      540

aagccaucua acgugcugau aaaugcucug ggccaaguca aaauguguga uuucggcauu      600

agcggguauc ucguggacuc cguggcaaag acaaucgacg ccggaugcaa acccuacaug      660

gcuccugaga gaauuaaccc agaguuaaau cagaaggguu auucagucaa aagugauauc      720

uggagccugg gcaucaccau gauugaacuu gccauauuga gguuuccgua cgacucuugg      780

gggacucccu uccagcagcu gaagcaaguu guggaggaac cuuccccaca gcuacccgcg      840

gauaaguuuu cagcagaguu cguagacuuu acaagccagu gucucaaaaa gaacaguaaa      900

gaacggccua ccuauccaga gcugaugcaa caccccuucu uuacgcuuca ugagucuaag      960

ggaacugaug uggccuccuu cgucaaacug aucuugggcg acuga                     1005


<210>  9002
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MKK6__Homo_sapiens__AAB05035

<400>  9002
augagccaga gcaagggcaa gaagagaaac cccggccuga agauccccaa ggaggccuuc       60

gagcagcccc agaccagcag cacccccccc agagaccugg acagcaaggc cugcaucagc      120

aucggcaacc agaacuucga ggugaaggcc gacgaccugg agcccaucau ggagcugggc      180

agaggcgccu acggcguggu ggagaagaug agacacgugc ccagcggcca gaucauggcc      240

gugaagagaa ucagagccac cgugaacagc caggagcaga agagacugcu gauggaccug      300

gacaucagca ugagaaccgu ggacugcccc uucaccguga ccuucuacgg cgcccuguuc      360

agagagggcg acguguggau cugcauggag cugauggaca ccagccugga caaguucuac      420

aagcagguga ucgacaaggg ccagaccauc cccgaggaca uccugggcaa gaucgccgug      480

agcaucguga aggcccugga gcaccugcac agcaagcuga gcgugaucca cagagacgug      540

aagcccagca acgugcugau caacgcccug ggccagguga agaugugcga cuucggcauc      600

agcggcuacc ugguggacag cguggccaag accaucgacg ccggcugcaa gcccuacaug      660

gcccccgaga gaaucaaccc cgagcugaac cagaagggcu acagcgugaa gagcgacauc      720

uggagccugg gcaucaccau gaucgagcug gccauccuga gauuccccua cgacagcugg      780

ggcacccccu uccagcagcu gaagcaggug guggaggagc ccagccccca gcugcccgcc      840

gacaaguuca gcgccgaguu cguggacuuc accagccagu gccugaagaa gaacagcaag      900

gagagaccca ccuaccccga gcugaugcag caccccuucu ucacccugca cgagagcaag      960

ggcaccgacg uggccagcuu cgugaagcug auccugggcg acuga                     1005


<210>  9003
<211>  1005
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MKK6__Homo_sapiens__AAB05035

<400>  9003
augagccagu ccaagggcaa aaagagaaac cccgggcuga aaaucccuaa ggaggccuuc       60

gaacaaccgc agaccucuag cacacccccu cgggaccucg auuccaaggc uugcauuucu      120

aucggaaauc agaacuuuga ggugaaagcc gacgaucugg aacccauuau ggagcuuggc      180

cgcggggcgu acggagucgu ugaaaagaug agacacgugc cuagcggcca gaucauggcu      240

gugaaacgga uucgcgccac ggucaauucc caagagcaga agagacugcu cauggaccug      300

gauaucucua ugcggaccgu ggacuguccc uucacaguua ccuuuuaugg ggcccuuuuc      360

cgcgagggag auguguggau cugcauggaa cugauggaca caagccucga uaaauuuuac      420

aagcagguca uugacaaagg ccagaccauc ccugaggaua uucugggcaa gaucgcugug      480

uccauuguua aggcccugga acaucuccac agcaaacugu cugugaucca uagagacguc      540

aagccgucca acgugcuuau uaaugcucug gggcaaguga aaauguguga uuucggaauc      600

agcggcuauc ucgucgacuc uguugccaag acaaucgacg cggggugcaa acccuacaug      660

gccccugagc ggauuaaccc cgagcugaau cagaagggau auuccgugaa aagcgauauc      720

uggucucuug gcauuaccau gaucgaacug gcuauucucc gcuuuccuua cgacuccugg      780

gggacgcccu uccagcagcu gaagcaagug gucgaggaac cgagcccuca gcugcccgcc      840

gauaaguuuu ccgcugaguu cguggacuuu accucucagu gucucaaaaa gaacagcaaa      900

gaaagaccua cauaucccga gcugaugcaa caccccuucu uuacccuuca ugaguccaag      960

ggaacagaug uugccagcuu cgugaaacug auccucggcg acuga                     1005


<210>  9004
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MKK7__Homo_sapiens__O14733

<400>  9004

Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys 
1               5                   10                  15      


Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu 
            20                  25                  30          


Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala 
        35                  40                  45              


Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His 
    50                  55                  60                  


Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr 
65                  70                  75                  80  


Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu 
                85                  90                  95      


Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg 
            100                 105                 110         


Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser 
        115                 120                 125             


Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His 
    130                 135                 140                 


Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn 
145                 150                 155                 160 


Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys 
                165                 170                 175     


Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val 
            180                 185                 190         


Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys 
        195                 200                 205             


Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val 
    210                 215                 220                 


Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile 
225                 230                 235                 240 


His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln 
                245                 250                 255     


Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys 
            260                 265                 270         


Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg 
        275                 280                 285             


Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp 
    290                 295                 300                 


Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe 
305                 310                 315                 320 


Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu 
                325                 330                 335     


Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp 
            340                 345                 350         


Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg 
        355                 360                 365             


Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu 
    370                 375                 380                 


Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys 
385                 390                 395                 400 


Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro 
                405                 410                 415     


Phe Phe Arg 
            


<210>  9005
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MKK7__Homo_sapiens__AAC26142

<400>  9005
auggcggcgu ccucccugga acagaagcug ucccgccugg aagcaaagcu gaagcaggag       60

aaccgggagg cccggcggag gaucgaccuc aaccuggaua ucagccccca gcggcccagg      120

cccacccugc agcucccgcu ggccaacgau gggggcagcc gcucgccauc cucagagagc      180

uccccgcagc accccacgcc ccccgcccgg ccccgccaca ugcuggggcu cccgucaacc      240

cuguucacac cccgcagcau ggagagcauu gagauugacc agaagcugca ggagaucaug      300

aagcagacgg gcuaccugac caucgggggc cagcgcuacc aggcagaaau caacgaccug      360

gagaacuugg gcgagauggg cagcggcacc ugcggccagg uguggaagau gcgcuuccgg      420

aagaccggcc acgucauugc cguuaagcaa augcggcgcu ccgggaacaa ggaggagaac      480

aagcgcaucc ucauggaccu ggauguggug cugaagagcc acgacugccc cuacaucgug      540

cagugcuuug ggacguucau caccaacacg gacgucuuca ucgccaugga gcucaugggc      600

accugcgcug agaagcucaa gaagcggaug cagggcccca uccccgagcg cauucugggc      660

aagaugacag uggcgauugu gaaggcgcug uacuaccuga aggagaagca cggugucauc      720

caccgcgacg ucaagcccuc caacauccug cuggacgagc ggggccagau caagcucugc      780

gacuucggca ucagcggccg ccugguggac uccaaagcca agacgcggag cgccggcugu      840

gccgccuaca uggcacccga gcgcauugac cccccagacc ccaccaagcc ggacuaugac      900

auccgggccg acguauggag ccugggcauc ucguuggugg agcuggcaac aggacaguuu      960

cccuacaaga acugcaagac ggacuuugag guccucacca aaguccuaca ggaagagccc     1020

ccgcuucugc ccggacacau gggcuucucg ggggacuucc aguccuucgu caaagacugc     1080

cuuacuaaag aucacaggaa gagaccaaag uauaauaagc uacuugaaca cagcuucauc     1140

aagcgcuacg agacgcugga gguggacgug gcguccuggu ucaaggaugu cauggcgaag     1200

acugagucac cgcggacuag cggcguccug agccagcccc accugcccuu cuucagguag     1260


<210>  9006
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MKK7__Homo_sapiens__AAC26142

<400>  9006
auggccgcca gcucccugga gcagaagcuc agccgccugg aggcgaagcu gaagcaggag       60

aaccgggagg cccgccggcg caucgaccuc aaccuggaca ucagccccca gcggccgcgc      120

cccacccugc agcucccccu ggccaacgac ggcggguccc ggucccccag cuccgagagc      180

uccccgcagc accccacccc gcccgcccgc ccccggcaca ugcugggccu ccccagcacg      240

cuguucacgc cccgcuccau ggagagcauc gagaucgacc agaagcugca ggagaucaug      300

aagcagaccg gguaccucac caucggcggg cagcgguacc aggccgagau caacgaccug      360

gagaaccugg gcgagauggg cuccgggacc ugcggccagg uguggaagau gcgcuuccgg      420

aagaccgggc acgucaucgc ggugaagcag augcgccgga gcggcaacaa ggaggagaac      480

aagcgcaucc ucauggaccu ggacgugguc cugaaguccc acgacugccc cuacaucgug      540

cagugcuucg ggaccuucau caccaacacg gacguguuca ucgccaugga gcucaugggg      600

accugcgccg agaagcugaa gaagcggaug cagggcccga uccccgagcg cauccugggc      660

aagaugaccg ucgccaucgu gaaggcgcuc uacuaccuga aggagaagca cggcgugauc      720

caccgggacg ucaagcccag caacauccug cucgacgagc gcgggcagau caagcugugc      780

gacuucggca ucuccggccg gcugguggac agcaaggcca agacccgcuc cgccgggugc      840

gccgccuaca uggcgcccga gcgcaucgac ccgcccgacc ccacgaagcc cgacuacgac      900

auccgggccg acguguggag ccucggcauc agccuggucg agcuggccac cgggcaguuc      960

ccguacaaga acugcaagac cgacuucgag gugcucacca aggugcugca ggaggagccg     1020

ccccugcucc ccggccacau gggguucucc ggcgacuucc agagcuucgu caaggacugc     1080

cugacgaagg accaccgcaa gcggcccaag uacaacaagc ugcucgagca cuccuucauc     1140

aagcgcuacg agacccugga gguggacgug gccagcuggu ucaaggacgu cauggccaag     1200

accgagagcc cccggaccuc cggcgugcug ucccagcccc accuccccuu cuuccgcuga     1260


<210>  9007
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MKK7__Homo_sapiens__AAC26142

<400>  9007
auggccgccu ccucccucga gcagaagcuc ucccgccucg aggccaagcu caagcaggag       60

aaccgcgagg cccgccgccg caucgaccuc aaccucgaca ucucccccca gcgcccccgc      120

cccacccucc agcucccccu cgccaacgac ggcggcuccc gcucccccuc cuccgagucc      180

uccccccagc accccacccc ccccgcccgc ccccgccaca ugcucggccu ccccuccacc      240

cucuucaccc cccgcuccau ggaguccauc gagaucgacc agaagcucca ggagaucaug      300

aagcagaccg gcuaccucac caucggcggc cagcgcuacc aggccgagau caacgaccuc      360

gagaaccucg gcgagauggg cuccggcacc ugcggccagg ucuggaagau gcgcuuccgc      420

aagaccggcc acgucaucgc cgucaagcag augcgccgcu ccggcaacaa ggaggagaac      480

aagcgcaucc ucauggaccu cgacgucguc cucaaguccc acgacugccc cuacaucguc      540

cagugcuucg gcaccuucau caccaacacc gacgucuuca ucgccaugga gcucaugggc      600

accugcgccg agaagcucaa gaagcgcaug cagggcccca uccccgagcg cauccucggc      660

aagaugaccg ucgccaucgu caaggcccuc uacuaccuca aggagaagca cggcgucauc      720

caccgcgacg ucaagcccuc caacauccuc cucgacgagc gcggccagau caagcucugc      780

gacuucggca ucuccggccg ccucgucgac uccaaggcca agacccgcuc cgccggcugc      840

gccgccuaca uggcccccga gcgcaucgac ccccccgacc ccaccaagcc cgacuacgac      900

auccgcgccg acgucugguc ccucggcauc ucccucgucg agcucgccac cggccaguuc      960

cccuacaaga acugcaagac cgacuucgag guccucacca agguccucca ggaggagccc     1020

ccccuccucc ccggccacau gggcuucucc ggcgacuucc aguccuucgu caaggacugc     1080

cucaccaagg accaccgcaa gcgccccaag uacaacaagc uccucgagca cuccuucauc     1140

aagcgcuacg agacccucga ggucgacguc gccuccuggu ucaaggacgu cauggccaag     1200

accgaguccc cccgcaccuc cggcguccuc ucccagcccc accuccccuu cuuccgcuga     1260


<210>  9008
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MKK7__Homo_sapiens__AAC26142

<400>  9008
auggccgcua gcucccugga gcagaagcuc ucuagacuug aagcaaaacu gaagcaagag       60

aacagggaag cccggcgccg aaucgacuug aauuuagaua uuucacccca gcguccuaga      120

ccaacccugc agcuaccgcu cgcgaacgac ggcgggagua ggagccccuc cucugagucg      180

ucaccucagc acccaacacc cccugcucgg ccacgccaua ugcugggacu ucccagcacu      240

cuguucacgc cuagaaguau ggaauccaua gagaucgauc aaaaauugca ggagauuaug      300

aagcagaccg guuaccucac aaucggcggg cagagguauc aagccgaaau uaaugaccug      360

gagaaccugg gagaaauggg cucugguacu ugcggacagg uguggaaaau gcgguuucgc      420

aagaccgggc acgucaucgc aguuaagcag augcgaagaa gcggcaauaa agaggagaac      480

aagaggauac ucauggauuu agacguggua cugaaauccc augauugucc auacaucgug      540

cagugcuucg gcacauuuau uaccaauacu gacgucuuca ucgccaugga acuuaugggg      600

acaugugcug agaaguugaa aaagcggaug caaggaccga uucccgaacg uauccugggu      660

aagaugaccg uggcaauagu uaaagcccua uauuaccuca aggagaaaca cggcgugauu      720

caucgcgaug ucaagccuuc aaacauccug cuugacgaaa gagggcagau uaaacugugc      780

gauuuuggaa ucaguggcag guugguggac agcaaggcua aaacgcgguc ugccgguugu      840

gcggcauaua uggccccaga gcgaaucgau cccccugacc caacuaagcc cgacuacgau      900

auucgcgcug acguaugguc ccucgggaua ucacugguug aguuagccac cggacaguuc      960

ccguauaaga auugcaaaac agauuuugaa gugcugacua agguccucca agaggaaccu     1020

ccccuucugc caggccacau gggcuucagc ggggacuuuc agaguuucgu gaaagauugu     1080

uugaccaagg accacagaaa aaggccuaag uacaacaagc uacuggagca uucuuuuauc     1140

aaacgguacg aaacacucga gguggauguc gcauccuggu ucaaggacgu uauggcuaaa     1200

accgagagcc cccgcacguc gggagugcug ucucagccac accuucccuu uuucagauga     1260


<210>  9009
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MKK7__Homo_sapiens__AAC26142

<400>  9009
auggccgcca gcagccugga gcagaagcug agcagacugg aggccaagcu gaagcaggag       60

aacagagagg ccagaagaag aaucgaccug aaccuggaca ucagccccca gagacccaga      120

cccacccugc agcugccccu ggccaacgac ggcggcagca gaagccccag cagcgagagc      180

agcccccagc accccacccc ccccgccaga cccagacaca ugcugggccu gcccagcacc      240

cuguucaccc ccagaagcau ggagagcauc gagaucgacc agaagcugca ggagaucaug      300

aagcagaccg gcuaccugac caucggcggc cagagauacc aggccgagau caacgaccug      360

gagaaccugg gcgagauggg cagcggcacc ugcggccagg uguggaagau gagauucaga      420

aagaccggcc acgugaucgc cgugaagcag augagaagaa gcggcaacaa ggaggagaac      480

aagagaaucc ugauggaccu ggacguggug cugaagagcc acgacugccc cuacaucgug      540

cagugcuucg gcaccuucau caccaacacc gacguguuca ucgccaugga gcugaugggc      600

accugcgccg agaagcugaa gaagagaaug cagggcccca uccccgagag aauccugggc      660

aagaugaccg uggccaucgu gaaggcccug uacuaccuga aggagaagca cggcgugauc      720

cacagagacg ugaagcccag caacauccug cuggacgaga gaggccagau caagcugugc      780

gacuucggca ucagcggcag acugguggac agcaaggcca agaccagaag cgccggcugc      840

gccgccuaca uggcccccga gagaaucgac ccccccgacc ccaccaagcc cgacuacgac      900

aucagagccg acguguggag ccugggcauc agccuggugg agcuggccac cggccaguuc      960

cccuacaaga acugcaagac cgacuucgag gugcugacca aggugcugca ggaggagccc     1020

ccccugcugc ccggccacau gggcuucagc ggcgacuucc agagcuucgu gaaggacugc     1080

cugaccaagg accacagaaa gagacccaag uacaacaagc ugcuggagca cagcuucauc     1140

aagagauacg agacccugga gguggacgug gccagcuggu ucaaggacgu gauggccaag     1200

accgagagcc ccagaaccag cggcgugcug agccagcccc accugcccuu cuucagauga     1260


<210>  9010
<211>  1260
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MKK7__Homo_sapiens__AAC26142

<400>  9010
auggccgcua gcucccugga gcagaagcuc ucuagacugg aagccaaacu uaagcaagag       60

aaccgggaag cgcgcagacg gaucgaccug aaucucgaua uuagccccca gcgcccuaga      120

ccgacccugc agcuuccccu ggcuaacgac ggcggguccc ggucuccuag cuccgagucu      180

agcccccagc acccuacacc cccugcccgc ccgagacaua ugcucggacu gcccuccacg      240

cuguucaccc cucggagcau ggaaucuauc gagauugauc aaaaacucca ggagaucaug      300

aagcagacag gcuaccugac cauuggggga cagcgcuauc aagccgaaau caaugaccuu      360

gagaaccugg gcgaaauggg guccggaaca ugcggccagg uguggaaaau gagauuucgg      420

aagaccggcc acgucaucgc uguuaagcag augcgcagaa gcgggaauaa agaggagaac      480

aagcggauuc ucauggaucu ggacguggug cuuaaaucuc augauugucc cuacaucguc      540

cagugcuucg gaacauuuau uaccaauacg gacguguuca ucgccaugga acugaugggc      600

accugugcug agaagcucaa aaagcgcaug caagggccua uucccgaaag aauccuggga      660

aagaugacag uugccauugu gaaagcgcug uauuaccuca aggagaaaca cggcgucauc      720

caucgggaug ugaagccguc caacauccug cuugacgaaa gagggcagau uaaacugugc      780

gauuuuggaa ucagcggccg ccucguugac ucuaaggcca aaacccgguc cgcuggcugu      840

gccgcuuaua uggccccuga gagaauugau cccccugacc ccacaaagcc cgacuacgau      900

auccgcgcgg acguguggag ccuggggauu ucccuugucg agcuggccac cggacaguuc      960

ccuuauaaga auugcaaaac ggauuuugaa gugcucacaa aggugcugca agaggaaccg     1020

ccccugcucc cuggccacau gggguucucu ggagacuuuc agagcuucgu caaagauugu     1080

cugaccaagg accaccggaa aagacccaag uacaacaaac uucuggagca uuccuuuauc     1140

aagcgcuacg aaacacucga gguugaugug gcuagcuggu ucaaggacgu gauggccaaa     1200

accgagucuc cucggaccuc cggcguccug agccagcccc accuuccguu uuucagauga     1260


<210>  9011
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MSTP104__Homo_sapiens__Q7Z4D5

<400>  9011

Met Lys Asp Gly Gln Lys Ile Leu Phe His Gly Glu Gly Asp Gln Glu 
1               5                   10                  15      


Pro Glu Leu Glu Pro Gly Asp Val Ile Ile Val Leu Asp Gln Lys Asp 
            20                  25                  30          


His Ser Val Phe Gln Arg Arg Gly His Asp Leu Ile Met Lys Met Lys 
        35                  40                  45              


Ile Gln Leu Ser Glu Ala Leu Cys Gly Phe Lys Lys Thr Ile Lys Thr 
    50                  55                  60                  


Leu Asp Asn Arg Ile Leu Val Ile Thr Ser Lys Ala Gly Glu Val Ile 
65                  70                  75                  80  


Lys His Gly Asp Leu Arg Cys Val Arg Asp Glu Gly Met Pro Ile Tyr 
                85                  90                  95      


Lys Ala Pro Leu Glu Lys Gly Ile Leu Ile Ile Gln Phe Leu Val Ile 
            100                 105                 110         


Phe Pro Glu Lys His Trp Leu Ser Leu Glu Lys Leu Pro Gln Leu Glu 
        115                 120                 125             


Ala Leu Leu Pro Pro Arg Gln Lys Val Arg Ile Thr Asp Asp Met Asp 
    130                 135                 140                 


Gln Val Glu Leu Lys Glu Phe Cys Pro Asn Glu Gln Asn Trp Arg Gln 
145                 150                 155                 160 


His Arg Glu Ala Tyr Glu Glu Asp Glu Asp Gly Pro Gln Ala Gly Val 
                165                 170                 175     


Gln Cys Gln Thr Ala 
            180     


<210>  9012
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MSTP104__Homo_sapiens__AAQ13629

<400>  9012
augaaagaug ggcaaaagau acuauuucau ggagaaggag aucaggagcc ugagcuggag       60

ccuggugaug ucauaauugu gcuugaucag aaggaucaua gugucuuuca gagacgaggc      120

caugacuuga ucaugaaaau gaaaauucag cuuucugaag cucuuugugg cuucaagaag      180

acgauaaaaa cauuggacaa ucgaauucuu guuauuacau ccaaagcagg ugaggugaua      240

aagcacgggg accugagaug cgugcgcgau gaaggaaugc ccaucuacaa agcaccccug      300

gaaaaaggga uucugaucau acaguuuuua guaaucuuuc cugaaaaaca cuggcuuucu      360

cuggaaaagc uuccucagcu ggaagcuuua cucccuccuc gacagaaagu gaggauuaca      420

gaugacaugg aucaggugga gcugaaggag uuuuguccca augagcagaa cuggcgucag      480

cacagggagg ccuacgagga ggacgaagac gggccccagg cuggagugca gugccagacg      540

gcauga                                                                 546


<210>  9013
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MSTP104__Homo_sapiens__AAQ13629

<400>  9013
augaaggacg gccagaagau ccuguuccac ggggagggcg accaggagcc cgagcucgag       60

ccgggggacg ugaucaucgu ccuggaccag aaggaccaca gcguguucca gcgccggggc      120

cacgaccuga ucaugaagau gaagauccag cucuccgagg cccugugcgg guucaagaag      180

accaucaaga cccuggacaa ccgcauccuc gugaucacga gcaaggccgg cgaggucauc      240

aagcacggcg accugcggug cgugcgcgac gaggggaugc ccaucuacaa ggcgccccug      300

gagaagggca uccucaucau ccaguuccug gugaucuucc ccgagaagca cuggcugucc      360

cucgagaagc ugccgcagcu ggaggcccuc cugccgcccc ggcagaaggu ccgcaucacc      420

gacgacaugg accaggugga gcugaaggag uucugcccca acgagcagaa cuggcggcag      480

caccgcgagg ccuacgagga ggacgaggac gggccccagg ccggcgugca gugccagacc      540

gccuga                                                                 546


<210>  9014
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MSTP104__Homo_sapiens__AAQ13629

<400>  9014
augaaggacg gccagaagau ccucuuccac ggcgagggcg accaggagcc cgagcucgag       60

cccggcgacg ucaucaucgu ccucgaccag aaggaccacu ccgucuucca gcgccgcggc      120

cacgaccuca ucaugaagau gaagauccag cucuccgagg cccucugcgg cuucaagaag      180

accaucaaga cccucgacaa ccgcauccuc gucaucaccu ccaaggccgg cgaggucauc      240

aagcacggcg accuccgcug cguccgcgac gagggcaugc ccaucuacaa ggccccccuc      300

gagaagggca uccucaucau ccaguuccuc gucaucuucc ccgagaagca cuggcucucc      360

cucgagaagc ucccccagcu cgaggcccuc cucccccccc gccagaaggu ccgcaucacc      420

gacgacaugg accaggucga gcucaaggag uucugcccca acgagcagaa cuggcgccag      480

caccgcgagg ccuacgagga ggacgaggac ggcccccagg ccggcgucca gugccagacc      540

gccuga                                                                 546


<210>  9015
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MSTP104__Homo_sapiens__AAQ13629

<400>  9015
augaaggacg gccagaaaau ccuguuccac ggggagggag aucaagaacc cgagcucgaa       60

ccuggugacg ugauuauagu ccuugaucag aaggaccaua gcguuuuuca gagaaggggc      120

cacgaucuga ucaugaaaau gaagauucag uuguccgagg ccuuaugcgg guucaaaaag      180

accaucaaga cacuggacaa ccggauucua gugaucacuu cuaaagcugg agaaguaaua      240

aagcauggcg aucuccgcug ugugcgagac gaggguaugc caaucuacaa agcaccgcug      300

gagaagggga uucuuaucau ucaauuucug gucaucuucc ccgaaaaaca cugguuguca      360

cucgagaagc ugccucagcu ggaagcccuc uuaccacccc gucagaaggu gagaauaacg      420

gaugacaugg aucagguuga gcugaaagag uuuugcccua augaacaaaa cuggaggcag      480

caucgggagg cguaugaaga ggacgaagau ggaccacagg cuggcgugca gugucaaacc      540

gccuga                                                                 546


<210>  9016
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MSTP104__Homo_sapiens__AAQ13629

<400>  9016
augaaggacg gccagaagau ccuguuccac ggcgagggcg accaggagcc cgagcuggag       60

cccggcgacg ugaucaucgu gcuggaccag aaggaccaca gcguguucca gagaagaggc      120

cacgaccuga ucaugaagau gaagauccag cugagcgagg cccugugcgg cuucaagaag      180

accaucaaga cccuggacaa cagaauccug gugaucacca gcaaggccgg cgaggugauc      240

aagcacggcg accugagaug cgugagagac gagggcaugc ccaucuacaa ggccccccug      300

gagaagggca uccugaucau ccaguuccug gugaucuucc ccgagaagca cuggcugagc      360

cuggagaagc ugccccagcu ggaggcccug cugcccccca gacagaaggu gagaaucacc      420

gacgacaugg accaggugga gcugaaggag uucugcccca acgagcagaa cuggagacag      480

cacagagagg ccuacgagga ggacgaggac ggcccccagg ccggcgugca gugccagacc      540

gccuga                                                                 546


<210>  9017
<211>  546
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MSTP104__Homo_sapiens__AAQ13629

<400>  9017
augaaggacg gccagaaaau ccuguuccac ggggagggag aucaagaacc cgagcucgaa       60

ccuggcgacg ugauuaucgu ccuggaucag aaggaccaua gcguuuuuca gagacggggg      120

cacgaucuua uuaugaaaau gaagauccag cuguccgagg cccucugcgg auucaaaaag      180

accauuaaga cacuggacaa ccgcauccuu gugaucacgu cuaaagcugg cgaagugauu      240

aagcaugggg aucugagaug uguccgggac gagggaaugc cgaucuacaa agcgccccuc      300

gagaagggca uucugaucau ucaauuucug gugaucuucc cugaaaaaca cuggcucagc      360

cuggagaaac uuccccagcu ggaagcccuc cugccucccc gccagaaggu uagaauuacc      420

gaugacaugg aucaggugga gcuuaaggag uuuugcccua augaacaaaa cuggcggcag      480

caucgcgagg cuuaugaaga ggacgaagau ggcccgcagg ccggggucca gugucaaaca      540

gccuga                                                                 546


<210>  9018
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MyD88__Homo_sapiens__Q99836

<400>  9018

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  9019
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  MyD88__Homo_sapiens__AAC50954

<400>  9019
auggcugcag gaggucccgg cgcggggucu gcggccccgg ucuccuccac auccucccuu       60

ccccuggcug cucucaacau gcgagugcgg cgccgccugu cucuguucuu gaacgugcgg      120

acacaggugg cggccgacug gaccgcgcug gcggaggaga uggacuuuga guacuuggag      180

auccggcaac uggagacaca agcggacccc acuggcaggc ugcuggacgc cuggcaggga      240

cgcccuggcg ccucuguagg ccgacugcuc gagcugcuua ccaagcuggg ccgcgacgac      300

gugcugcugg agcugggacc cagcauugag gaggauugcc aaaaguauau cuugaagcag      360

cagcaggagg aggcugagaa gccuuuacag guggccgcug uagacagcag ugucccacgg      420

acagcagagc uggcgggcau caccacacuu gaugaccccc uggggcauau gccugagcgu      480

uucgaugccu ucaucugcua uugccccagc gacauccagu uugugcagga gaugauccgg      540

caacuggaac agacaaacua ucgacugaag uugugugugu cugaccgcga uguccugccu      600

ggcaccugug ucuggucuau ugcuagugag cucaucgaaa agaggugccg ccggauggug      660

gugguugucu cugaugauua ccugcagagc aaggaaugug acuuccagac caaauuugca      720

cucagccucu cuccaggugc ccaucagaag cgacugaucc ccaucaagua caaggcaaug      780

aagaaagagu uccccagcau ccugagguuc aucacugucu gcgacuacac caaccccugc      840

accaaaucuu gguucuggac ucgccuugcc aaggccuugu cccugcccug a               891


<210>  9020
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       MyD88__Homo_sapiens__AAC50954

<400>  9020
auggccgccg gcgggcccgg cgcggggagc gccgccccgg uguccagcac cuccagccug       60

ccccucgccg cccugaacau gcgcguccgg cgccggcugu cccucuuccu gaacgugcgc      120

acccaggugg cggccgacug gacggcccug gccgaggaga uggacuucga guaccucgag      180

auccggcagc uggagaccca ggcggacccc accggccgcc ugcucgacgc cuggcagggg      240

cggcccggcg ccagcgucgg ccgccugcug gagcuccuga ccaagcuggg gcgggacgac      300

gugcuccugg agcugggccc guccaucgag gaggacugcc agaaguacau ccucaagcag      360

cagcaggagg aggccgagaa gccccuccag guggccgcgg ucgacagcuc cgugccccgc      420

acggccgagc uggccgggau caccacccug gacgaccccc ugggccacau gccggagcgg      480

uucgacgccu ucaucugcua cugccccagc gacauccagu ucgugcagga gaugauccgc      540

cagcuggagc agaccaacua ccggcucaag cugugcgucu ccgaccgcga cgugcugccc      600

gggacgugcg uguggagcau cgccuccgag cucaucgaga agcggugccg ccggaugguc      660

guggugguca gcgacgacua ccugcagucc aaggagugcg acuuccagac caaguucgcg      720

cugagccucu cccccggcgc ccaccagaag cgccugaucc cgaucaagua caaggccaug      780

aagaaggagu uccccagcau ccugcgguuc aucaccgugu gcgacuacac caaccccugc      840

acgaaguccu gguucuggac ccgccucgcc aaggcccuga gccugcccug a               891


<210>  9021
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       MyD88__Homo_sapiens__AAC50954

<400>  9021
auggccgccg gcggccccgg cgccggcucc gccgcccccg ucuccuccac cuccucccuc       60

ccccucgccg cccucaacau gcgcguccgc cgccgccucu cccucuuccu caacguccgc      120

acccaggucg ccgccgacug gaccgcccuc gccgaggaga uggacuucga guaccucgag      180

auccgccagc ucgagaccca ggccgacccc accggccgcc uccucgacgc cuggcagggc      240

cgccccggcg ccuccgucgg ccgccuccuc gagcuccuca ccaagcucgg ccgcgacgac      300

guccuccucg agcucggccc cuccaucgag gaggacugcc agaaguacau ccucaagcag      360

cagcaggagg aggccgagaa gccccuccag gucgccgccg ucgacuccuc cgucccccgc      420

accgccgagc ucgccggcau caccacccuc gacgaccccc ucggccacau gcccgagcgc      480

uucgacgccu ucaucugcua cugccccucc gacauccagu ucguccagga gaugauccgc      540

cagcucgagc agaccaacua ccgccucaag cucugcgucu ccgaccgcga cguccucccc      600

ggcaccugcg ucugguccau cgccuccgag cucaucgaga agcgcugccg ccgcaugguc      660

gucgucgucu ccgacgacua ccuccagucc aaggagugcg acuuccagac caaguucgcc      720

cucucccucu cccccggcgc ccaccagaag cgccucaucc ccaucaagua caaggccaug      780

aagaaggagu uccccuccau ccuccgcuuc aucaccgucu gcgacuacac caaccccugc      840

accaaguccu gguucuggac ccgccucgcc aaggcccucu cccuccccug a               891


<210>  9022
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       MyD88__Homo_sapiens__AAC50954

<400>  9022
auggccgcug gcgggcccgg agcagguagc gccgcgccug uguccucuac cucaagucug       60

ccacucgcug cccuuaacau gagagucagg cggcgccuga gcuuguucuu aaauguucga      120

acacaggugg cagccgacug gacugcucug gcagaggaaa uggauuuuga guaccuagaa      180

auccgucaac ucgagacgca ggccgacccg accggcagac ugcuugaugc uuggcagggg      240

aggcccggag ccuccguagg ccggcuguug gaacuccuga caaagcuggg ucgcgacgau      300

gugcucuuag agcuggggcc uucuauugag gaagacugcc agaaauauau acuuaagcaa      360

cagcaggagg aagcggagaa accauugcag gucgcagccg uggauucguc aguucccaga      420

acugcugagc uggccggaau caccacacua gacgauccuc ucggccacau gccagaaagg      480

uucgacgcau uuauuuguua cugccccagc gauauccaau ucgugcagga gaugauucgg      540

cagcuggaac agaccaacua ucgccuuaag cuguguguca gugaccgaga uguguugccu      600

ggcacuugcg uaugguccau cgcuucugag cucauagaga aaagauguag gcggaugguu      660

guggucguga gcgacgacua ccugcaaucc aaggaaugcg auuuucagac aaaguucgcc      720

uuaucacuga guccaggggc gcaucagaaa cgucucaucc cgauuaagua uaaagccaug      780

aagaaagagu uucccagcau ccuucgcuuc auuaccgugu gugacuacac gaauccuugc      840

acuaagucuu gguuuuggac cagacuggca aaggcuuugu cccuaccaug a               891


<210>  9023
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       MyD88__Homo_sapiens__AAC50954

<400>  9023
auggccgccg gcggccccgg cgccggcagc gccgcccccg ugagcagcac cagcagccug       60

ccccuggccg cccugaacau gagagugaga agaagacuga gccuguuccu gaacgugaga      120

acccaggugg ccgccgacug gaccgcccug gccgaggaga uggacuucga guaccuggag      180

aucagacagc uggagaccca ggccgacccc accggcagac ugcuggacgc cuggcagggc      240

agacccggcg ccagcguggg cagacugcug gagcugcuga ccaagcuggg cagagacgac      300

gugcugcugg agcugggccc cagcaucgag gaggacugcc agaaguacau ccugaagcag      360

cagcaggagg aggccgagaa gccccugcag guggccgccg uggacagcag cgugcccaga      420

accgccgagc uggccggcau caccacccug gacgaccccc ugggccacau gcccgagaga      480

uucgacgccu ucaucugcua cugccccagc gacauccagu ucgugcagga gaugaucaga      540

cagcuggagc agaccaacua cagacugaag cugugcguga gcgacagaga cgugcugccc      600

ggcaccugcg uguggagcau cgccagcgag cugaucgaga agagaugcag aagaauggug      660

guggugguga gcgacgacua ccugcagagc aaggagugcg acuuccagac caaguucgcc      720

cugagccuga gccccggcgc ccaccagaag agacugaucc ccaucaagua caaggccaug      780

aagaaggagu uccccagcau ccugagauuc aucaccgugu gcgacuacac caaccccugc      840

accaagagcu gguucuggac cagacuggcc aaggcccuga gccugcccug a               891


<210>  9024
<211>  891
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       MyD88__Homo_sapiens__AAC50954

<400>  9024
auggccgcug gcgggcccgg agccggcagc gcggcuccug uguccucuac cagcucccug       60

ccgcucgccg cccugaacau gagaguccgg cgcagacuuu cucuguuccu caauguucgg      120

acacaggugg cugccgacug gacggcucug gccgaggaaa uggauuuuga guaccuugaa      180

auccgccaac uggagaccca ggcggacccc acagggagac uccuggaugc cuggcaggga      240

cggccuggcg cuagcguggg gcgccugcuc gaacugcuua ccaagcuggg aagagacgau      300

guccuccugg agcuuggccc cuccauugag gaagacugcc agaaauauau ccugaagcaa      360

cagcaggagg aagccgagaa accucuccag guggcugccg uugauucuag cgugccccgg      420

acagcggagc uggccggcau uaccacacug gacgauccuc ucgggcacau gccggaacgc      480

uucgacgcuu uuaucuguua cugccccucc gauauucaau ucguccagga gaugaucaga      540

cagcuggaac agaccaacua ucggcuuaag cuguguguga gcgaccgcga uguucucccu      600

ggaacgugcg uguggucuau cgccuccgag cugauugaga aaagaugucg gcgcaugguc      660

guggugguca gcgacgacua ccuucaaucu aaggaaugcg auuuucagac caaguucgcu      720

cugucccuca gccccggcgc ccaucagaaa agacugaucc cuauuaagua uaaagccaug      780

aagaaagagu uucccucuau ccugcgguuc auuacaguuu gugacuacac caauccgugc      840

acaaaguccu gguuuuggac cagacucgcu aaggcgcuga gccuuccuug a               891


<210>  9025
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP10__Homo_sapiens__Q86W26

<400>  9025

Met Ala Met Ala Lys Ala Arg Lys Pro Arg Glu Ala Leu Leu Trp Ala 
1               5                   10                  15      


Leu Ser Asp Leu Glu Glu Asn Asp Phe Lys Lys Leu Lys Phe Tyr Leu 
            20                  25                  30          


Arg Asp Met Thr Leu Ser Glu Gly Gln Pro Pro Leu Ala Arg Gly Glu 
        35                  40                  45              


Leu Glu Gly Leu Ile Pro Val Asp Leu Ala Glu Leu Leu Ile Ser Lys 
    50                  55                  60                  


Tyr Gly Glu Lys Glu Ala Val Lys Val Val Leu Lys Gly Leu Lys Val 
65                  70                  75                  80  


Met Asn Leu Leu Glu Leu Val Asp Gln Leu Ser His Ile Cys Leu His 
                85                  90                  95      


Asp Tyr Arg Glu Val Tyr Arg Glu His Val Arg Cys Leu Glu Glu Trp 
            100                 105                 110         


Gln Glu Ala Gly Val Asn Gly Arg Tyr Asn Gln Val Leu Leu Val Ala 
        115                 120                 125             


Lys Pro Ser Ser Glu Ser Pro Glu Ser Leu Ala Cys Pro Phe Pro Glu 
    130                 135                 140                 


Gln Glu Leu Glu Ser Val Thr Val Glu Ala Leu Phe Asp Ser Gly Glu 
145                 150                 155                 160 


Lys Pro Ser Leu Ala Pro Ser Leu Val Val Leu Gln Gly Ser Ala Gly 
                165                 170                 175     


Thr Gly Lys Thr Thr Leu Ala Arg Lys Met Val Leu Asp Trp Ala Thr 
            180                 185                 190         


Gly Thr Leu Tyr Pro Gly Arg Phe Asp Tyr Val Phe Tyr Val Ser Cys 
        195                 200                 205             


Lys Glu Val Val Leu Leu Leu Glu Ser Lys Leu Glu Gln Leu Leu Phe 
    210                 215                 220                 


Trp Cys Cys Gly Asp Asn Gln Ala Pro Val Thr Glu Ile Leu Arg Gln 
225                 230                 235                 240 


Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Phe Asp Glu Leu Gln Arg 
                245                 250                 255     


Pro Phe Glu Glu Lys Leu Lys Lys Arg Gly Leu Ser Pro Lys Glu Ser 
            260                 265                 270         


Leu Leu His Leu Leu Ile Arg Arg His Thr Leu Pro Thr Cys Ser Leu 
        275                 280                 285             


Leu Ile Thr Thr Arg Pro Leu Ala Leu Arg Asn Leu Glu Pro Leu Leu 
    290                 295                 300                 


Lys Gln Ala Arg His Val His Ile Leu Gly Phe Ser Glu Glu Glu Arg 
305                 310                 315                 320 


Ala Arg Tyr Phe Ser Ser Tyr Phe Thr Asp Glu Lys Gln Ala Asp Arg 
                325                 330                 335     


Ala Phe Asp Ile Val Gln Lys Asn Asp Ile Leu Tyr Lys Ala Cys Gln 
            340                 345                 350         


Val Pro Gly Ile Cys Trp Val Val Cys Ser Trp Leu Gln Gly Gln Met 
        355                 360                 365             


Glu Arg Gly Lys Val Val Leu Glu Thr Pro Arg Asn Ser Thr Asp Ile 
    370                 375                 380                 


Phe Met Ala Tyr Val Ser Thr Phe Leu Pro Pro Asp Asp Asp Gly Gly 
385                 390                 395                 400 


Cys Ser Glu Leu Ser Arg His Arg Val Leu Arg Ser Leu Cys Ser Leu 
                405                 410                 415     


Ala Ala Glu Gly Ile Gln His Gln Arg Phe Leu Phe Glu Glu Ala Glu 
            420                 425                 430         


Leu Arg Lys His Asn Leu Asp Gly Pro Arg Leu Ala Ala Phe Leu Ser 
        435                 440                 445             


Ser Asn Asp Tyr Gln Leu Gly Leu Ala Ile Lys Lys Phe Tyr Ser Phe 
    450                 455                 460                 


Arg His Ile Ser Phe Gln Asp Phe Phe His Ala Met Ser Tyr Leu Val 
465                 470                 475                 480 


Lys Glu Asp Gln Ser Arg Leu Gly Lys Glu Ser Arg Arg Glu Val Gln 
                485                 490                 495     


Arg Leu Leu Glu Val Lys Glu Gln Glu Gly Asn Asp Glu Met Thr Leu 
            500                 505                 510         


Thr Met Gln Phe Leu Leu Asp Ile Ser Lys Lys Asp Ser Phe Ser Asn 
        515                 520                 525             


Leu Glu Leu Lys Phe Cys Phe Arg Ile Ser Pro Cys Leu Ala Gln Asp 
    530                 535                 540                 


Leu Lys His Phe Lys Glu Gln Met Glu Ser Met Lys His Asn Arg Thr 
545                 550                 555                 560 


Trp Asp Leu Glu Phe Ser Leu Tyr Glu Ala Lys Ile Lys Asn Leu Val 
                565                 570                 575     


Lys Gly Ile Gln Met Asn Asn Val Ser Phe Lys Ile Lys His Ser Asn 
            580                 585                 590         


Glu Lys Lys Ser Gln Ser Gln Asn Leu Phe Ser Val Lys Ser Ser Leu 
        595                 600                 605             


Ser His Gly Pro Lys Glu Glu Gln Lys Cys Pro Ser Val His Gly Gln 
    610                 615                 620                 


Lys Glu Gly Lys Asp Asn Ile Ala Gly Thr Gln Lys Glu Ala Ser Thr 
625                 630                 635                 640 


Gly Lys Gly Arg Gly Thr Glu Glu Thr Pro Lys Asn Thr Tyr Ile 
                645                 650                 655 


<210>  9026
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP10__Homo_sapiens__AAI04958

<400>  9026
auggccaugg ccaaggccag aaagccccgg gaggcauugc ucugggccuu gagugaccuu       60

gaggagaacg auuucaagaa guuaaaguuc uacuuacggg auaugacccu gucugagggc      120

cagcccccac uggccagagg ggaguuggag ggccugauuc cgguggaccu ggcagaauua      180

cugauuucaa aguauggaga aaaggaggcu gugaaaguug uccucaaggg cuugaagguc      240

augaaccugu uggaacuugu ggaccagcuc agccauauuu gucugcauga uuacagagaa      300

guauaccgag agcaugugcg cugccuagag gaauggcagg aagcaggagu caauggcaga      360

uacaaccagg ugcuccuggu ggccaagccc agcucagaga gcccagaauc acuugccugc      420

cccuucccgg agcaggagcu ggagucuguc acgguggagg cucuauuuga uucaggggaa      480

aagcccucac uggccccauc cuuaguugug cuacaggggu cggcuggcac uggaaagaca      540

acucucgcca gaaaaauggu guuggacugg gccaccggua cucuguaccc aggccgguuu      600

gauuaugucu uuuauguaag cugcaaagaa gugguccugc ugcuggagag caaacuggag      660

cagcuccuuu ucuggugcug cggggacaau caagccccug ucacagagau ucugaggcag      720

ccagagcggc uccuguucau ccuggauggc uuugaugagc ugcagaggcc cuuugaagaa      780

aaguugaaga agagggguuu gagucccaag gagagccugc ugcaccuucu aauuaggaga      840

cauacacucc ccacgugcuc ccuucucauc accacccggc cccuggcuuu gaggaaucug      900

gagcccuugc ugaaacaagc acgucauguc cauauccuag gcuucucuga ggaggagagg      960

gcgagguacu ucagcuccua uuucacggau gagaagcaag cugaccgugc cuucgacauu     1020

guacagaaaa augacauucu cuacaaagcg ugucagguuc caggcauuug cugggugguc     1080

ugcuccuggc ugcaggggca gauggagaga ggcaaaguug ucuuagagac accuagaaac     1140

agcacugaca ucuucauggc uuacgucucc accuuucugc cgcccgauga ugaugggggc     1200

ugcuccgagc uuucccggca caggguccug aggagucugu gcucccuagc agcugaaggg     1260

auucagcacc agagguuccu auuugaagaa gcugagcuca ggaaacauaa uuuagauggc     1320

cccaggcuug ccgcuuuccu gaguaguaac gacuaccaau ugggacuugc caucaagaag     1380

uucuacagcu uccgccacau cagcuuccag gacuuuuuuc augccauguc uuaccuggug     1440

aaagaggacc aaagccggcu ggggaaggag ucccgcagag aagugcaaag gcugcuggag     1500

guaaaggagc aggaagggaa ugaugagaug acccucacua ugcaguuuuu acuggacauc     1560

ucgaaaaaag acagcuucuc gaacuuggag cucaaguucu gcuucagaau uucucccugu     1620

uuagcgcagg aucugaagca uuuuaaagaa cagauggaau cuaugaagca caacaggacc     1680

ugggauuugg aauucucccu guaugaagcu aaaauaaaga aucugguaaa agguauucag     1740

augaacaaug uaucauucaa gauaaaacau ucaaaugaaa agaaaucaca gagccagaau     1800

uuauuuucug ucaaaagcag cuugagucau ggaccuaagg aggagcaaaa auguccuucu     1860

guccauggac agaaggaggg caaagauaau auagcaggaa cacaaaagga agcuucuacu     1920

ggaaaaggca gagggacaga ggaaacacca aaaaauacuu acauauaa                  1968


<210>  9027
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP10__Homo_sapiens__AAI04958

<400>  9027
auggccaugg ccaaggcgcg caagccccgg gaggcccugc ucugggcccu gagcgaccug       60

gaggagaacg acuucaagaa gcucaaguuc uaccugcgcg acaugacccu guccgagggc      120

cagccgcccc ucgcccgcgg ggagcuggag ggccugaucc ccguggaccu cgccgagcug      180

cugaucagca aguacgggga gaaggaggcg gucaaggugg ugcucaaggg ccugaagguc      240

augaaccugc ucgagcuggu ggaccagcug ucccacaucu gccuccacga cuaccgggag      300

guguaccggg agcacguccg cugccuggag gaguggcagg aggccggggu gaacggccgg      360

uacaaccagg ugcugcucgu cgccaagccc agcuccgaga gcccggaguc ccuggccugc      420

cccuuccccg agcaggagcu ggagagcgug accguggagg cgcuguucga cuccggcgag      480

aagcccagcc uggccccguc ccuggucgug cuccagggga gcgccggcac ggggaagacc      540

acccuggccc gcaagauggu gcuggacugg gccaccggca cgcucuaccc cgggcgguuc      600

gacuacgucu ucuacguguc cugcaaggag gugguccugc ugcucgagag caagcuggag      660

cagcugcugu ucuggugcug cggcgacaac caggcgcccg ugaccgagau ccugcgccag      720

cccgagcggc uccucuucau ccuggacggc uucgacgagc ugcagcgccc guucgaggag      780

aagcucaaga agcgggggcu gucccccaag gagagccugc uccaccuccu gauccgccgg      840

cacacccucc cgaccugcuc ccugcugauc acgacccgcc cccuggcccu ccggaaccug      900

gagccccugc ucaagcaggc ccgccacgug cacauccugg gcuucagcga ggaggagcgg      960

gcccgcuacu ucuccagcua cuucaccgac gagaagcagg ccgaccgggc guucgacauc     1020

guccagaaga acgacauccu guacaaggcc ugccaggugc ccgggaucug cugggugguc     1080

ugcagcuggc uccagggcca gauggagcgc ggcaaggugg uccuggagac gccccgcaac     1140

uccaccgaca ucuucauggc cuacgugagc accuuccugc ccccggacga cgacgggggc     1200

ugcuccgagc ucagccggca ccgcgugcug cggucccugu gcagccucgc cgccgagggg     1260

auccagcacc agcgcuuccu guucgaggag gcggagcugc ggaagcacaa ccucgacggc     1320

ccccgccugg ccgccuuccu guccagcaac gacuaccagc ucgggcuggc caucaagaag     1380

uucuacuccu uccggcacau cagcuuccag gacuucuucc acgccauguc cuaccugguc     1440

aaggaggacc agagccgccu cggcaaggag ucccggcgcg aggugcagcg gcugcuggag     1500

gugaaggagc aggagggcaa cgacgagaug acccucacca ugcaguuccu gcuggacauc     1560

agcaagaagg acuccuucag caaccucgag cugaaguucu gcuuccgcau cucccccugc     1620

cuggcgcagg accucaagca cuucaaggag cagauggaga gcaugaagca caaccggacg     1680

ugggaccugg aguucucccu guacgaggcc aagaucaaga accucgucaa ggggauccag     1740

augaacaacg ugagcuucaa gaucaagcac agcaacgaga agaaguccca gagccagaac     1800

cuguucuccg ucaagagcuc ccugagccac ggccccaagg aggagcagaa gugcccgucc     1860

gugcacgggc agaaggaggg caaggacaac aucgccggga cccagaagga ggccagcacc     1920

ggcaagggcc gcgggaccga ggagacgccc aagaacaccu acaucuga                  1968


<210>  9028
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP10__Homo_sapiens__AAI04958

<400>  9028
auggccaugg ccaaggcccg caagccccgc gaggcccucc ucugggcccu cuccgaccuc       60

gaggagaacg acuucaagaa gcucaaguuc uaccuccgcg acaugacccu cuccgagggc      120

cagccccccc ucgcccgcgg cgagcucgag ggccucaucc ccgucgaccu cgccgagcuc      180

cucaucucca aguacggcga gaaggaggcc gucaaggucg uccucaaggg ccucaagguc      240

augaaccucc ucgagcucgu cgaccagcuc ucccacaucu gccuccacga cuaccgcgag      300

gucuaccgcg agcacguccg cugccucgag gaguggcagg aggccggcgu caacggccgc      360

uacaaccagg uccuccucgu cgccaagccc uccuccgagu cccccgaguc ccucgccugc      420

cccuuccccg agcaggagcu cgaguccguc accgucgagg cccucuucga cuccggcgag      480

aagcccuccc ucgcccccuc ccucgucguc cuccagggcu ccgccggcac cggcaagacc      540

acccucgccc gcaagauggu ccucgacugg gccaccggca cccucuaccc cggccgcuuc      600

gacuacgucu ucuacgucuc cugcaaggag gucguccucc uccucgaguc caagcucgag      660

cagcuccucu ucuggugcug cggcgacaac caggcccccg ucaccgagau ccuccgccag      720

cccgagcgcc uccucuucau ccucgacggc uucgacgagc uccagcgccc cuucgaggag      780

aagcucaaga agcgcggccu cucccccaag gagucccucc uccaccuccu cauccgccgc      840

cacacccucc ccaccugcuc ccuccucauc accacccgcc cccucgcccu ccgcaaccuc      900

gagccccucc ucaagcaggc ccgccacguc cacauccucg gcuucuccga ggaggagcgc      960

gcccgcuacu ucuccuccua cuucaccgac gagaagcagg ccgaccgcgc cuucgacauc     1020

guccagaaga acgacauccu cuacaaggcc ugccaggucc ccggcaucug cugggucguc     1080

ugcuccuggc uccagggcca gauggagcgc ggcaaggucg uccucgagac cccccgcaac     1140

uccaccgaca ucuucauggc cuacgucucc accuuccucc cccccgacga cgacggcggc     1200

ugcuccgagc ucucccgcca ccgcguccuc cgcucccucu gcucccucgc cgccgagggc     1260

auccagcacc agcgcuuccu cuucgaggag gccgagcucc gcaagcacaa ccucgacggc     1320

ccccgccucg ccgccuuccu cuccuccaac gacuaccagc ucggccucgc caucaagaag     1380

uucuacuccu uccgccacau cuccuuccag gacuucuucc acgccauguc cuaccucguc     1440

aaggaggacc agucccgccu cggcaaggag ucccgccgcg agguccagcg ccuccucgag     1500

gucaaggagc aggagggcaa cgacgagaug acccucacca ugcaguuccu ccucgacauc     1560

uccaagaagg acuccuucuc caaccucgag cucaaguucu gcuuccgcau cucccccugc     1620

cucgcccagg accucaagca cuucaaggag cagauggagu ccaugaagca caaccgcacc     1680

ugggaccucg aguucucccu cuacgaggcc aagaucaaga accucgucaa gggcauccag     1740

augaacaacg ucuccuucaa gaucaagcac uccaacgaga agaaguccca gucccagaac     1800

cucuucuccg ucaaguccuc ccucucccac ggccccaagg aggagcagaa gugccccucc     1860

guccacggcc agaaggaggg caaggacaac aucgccggca cccagaagga ggccuccacc     1920

ggcaagggcc gcggcaccga ggagaccccc aagaacaccu acaucuga                  1968


<210>  9029
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP10__Homo_sapiens__AAI04958

<400>  9029
auggccaugg cuaaggcaag aaaacccagg gaggcccugc ucugggcgcu uagcgaccug       60

gaagagaacg auuucaagaa auugaaguuu uacuuacggg acaugacccu guccgaaggc      120

cagccuccac uagcucgcgg ggagcucgaa ggacugaucc cgguggaucu ugccgagcug      180

uugauuucua aauaugguga gaaggaagca gucaagguug ugcucaaagg ccugaaggua      240

augaaucugc ucgaguuagu ggaccaacug ucacacauau gccuucauga uuaccgagaa      300

gucuaucgug agcacgugag auguuuggag gaauggcagg aggccggggu uaacggaagg      360

uacaaucagg ugcugcuagu cgcuaaaccc aguagcgaau ccccugaguc ucucgcaugc      420

ccauuccccg aacaggagcu ggagucggug acaguagaag cccuuuuuga cucaggcgag      480

aagccuagcc uggcuccaag uuugguugug cuccaagguu ccgccgggac uggaaaaacg      540

acccuggcgc ggaagauggu cuuagauugg gcaacaggca cucuguaucc cggccgcuuc      600

gacuacgugu uuuauguguc uuguaaggaa gucguucucc uucuggagag caaauuggaa      660

cagcuacugu ucuggugcug uggggauaac caggccccug ugaccgagau ccucagacag      720

ccagagaggc ugcuuuuuau ucuggacgga uucgaugaau ugcaacggcc guuugaggaa      780

aagcucaaaa agcgcggucu gucccccaaa gagucauuac ugcaucuacu cauccgaaga      840

cacacacugc cuaccugcag ucuuuugauu acuacaaggc cacuggcucu ccggaaucug      900

gaaccccuuc ugaagcaggc ccgucaugua cacaucuugg gcuucagcga ggaggaacgc      960

gcaagauacu uuucuuccua cuucaccgac gagaaacagg cugauagggc cuuugacaua     1020

gugcagaaga acgacauccu cuauaaggcg ugucaagucc cugggauuug cugggugguu     1080

uguucauggc ugcagggaca gauggaacgg ggcaaagugg ucuuagagac gccacgaaau     1140

agcacugaua ucuucauggc cuacgugagu accuuccugc ccccggacga ugacgguggg     1200

ugcucugagc uaucccgcca cagaguacuc aggagccugu guucgcuugc agcugaaggc     1260

auucaacauc agcgguuuuu guucgaggaa gccgagcugc gcaagcacaa ccucgaugga     1320

ccuagacugg cugccuuuuu aucuuccaau gacuaucagc ugggccuugc aaucaaaaag     1380

uucuacucau uuaggcauau aaguuuccag gauuucuucc acgccaugag cuauuugguu     1440

aaagaagacc aaucccgucu cgggaaggag ucucggcgag aggugcagag acugcuagaa     1500

gucaaggagc aggaaggaaa cgaugagaug acacugacua ugcaguuucu ccuggacauu     1560

agcaaaaagg auucauucag uaaucuugaa uugaaauuuu gcuucaggau cucccccugc     1620

cuggcucaag acuuaaagca cuuuaaagag cagauggaga gcaugaagca uaaccgcacc     1680

ugggaccucg aauuuucucu guacgaggcg aagauuaaaa aucuugugaa ggguauccag     1740

augaacaaug ucucauucaa aaucaagcac aguaacgaga aaaagagcca gucccaaaac     1800

cuguuuucug ugaagucgag cuugucccau ggcccaaaag aagaacagaa guguccuuca     1860

guucacgggc agaaagaggg aaaggauaau auugcaggca cacagaaaga ggccaguacc     1920

gguaaggggc ggggcacgga agagacuccc aaaaacacau auauauga                  1968


<210>  9030
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP10__Homo_sapiens__AAI04958

<400>  9030
auggccaugg ccaaggccag aaagcccaga gaggcccugc ugugggcccu gagcgaccug       60

gaggagaacg acuucaagaa gcugaaguuc uaccugagag acaugacccu gagcgagggc      120

cagccccccc uggccagagg cgagcuggag ggccugaucc ccguggaccu ggccgagcug      180

cugaucagca aguacggcga gaaggaggcc gugaaggugg ugcugaaggg ccugaaggug      240

augaaccugc uggagcuggu ggaccagcug agccacaucu gccugcacga cuacagagag      300

guguacagag agcacgugag augccuggag gaguggcagg aggccggcgu gaacggcaga      360

uacaaccagg ugcugcuggu ggccaagccc agcagcgaga gccccgagag ccuggccugc      420

cccuuccccg agcaggagcu ggagagcgug accguggagg cccuguucga cagcggcgag      480

aagcccagcc uggcccccag ccugguggug cugcagggca gcgccggcac cggcaagacc      540

acccuggcca gaaagauggu gcuggacugg gccaccggca cccuguaccc cggcagauuc      600

gacuacgugu ucuacgugag cugcaaggag guggugcugc ugcuggagag caagcuggag      660

cagcugcugu ucuggugcug cggcgacaac caggcccccg ugaccgagau ccugagacag      720

cccgagagac ugcuguucau ccuggacggc uucgacgagc ugcagagacc cuucgaggag      780

aagcugaaga agagaggccu gagccccaag gagagccugc ugcaccugcu gaucagaaga      840

cacacccugc ccaccugcag ccugcugauc accaccagac cccuggcccu gagaaaccug      900

gagccccugc ugaagcaggc cagacacgug cacauccugg gcuucagcga ggaggagaga      960

gccagauacu ucagcagcua cuucaccgac gagaagcagg ccgacagagc cuucgacauc     1020

gugcagaaga acgacauccu guacaaggcc ugccaggugc ccggcaucug cuggguggug     1080

ugcagcuggc ugcagggcca gauggagaga ggcaaggugg ugcuggagac ccccagaaac     1140

agcaccgaca ucuucauggc cuacgugagc accuuccugc cccccgacga cgacggcggc     1200

ugcagcgagc ugagcagaca cagagugcug agaagccugu gcagccuggc cgccgagggc     1260

auccagcacc agagauuccu guucgaggag gccgagcuga gaaagcacaa ccuggacggc     1320

cccagacugg ccgccuuccu gagcagcaac gacuaccagc ugggccuggc caucaagaag     1380

uucuacagcu ucagacacau cagcuuccag gacuucuucc acgccaugag cuaccuggug     1440

aaggaggacc agagcagacu gggcaaggag agcagaagag aggugcagag acugcuggag     1500

gugaaggagc aggagggcaa cgacgagaug acccugacca ugcaguuccu gcuggacauc     1560

agcaagaagg acagcuucag caaccuggag cugaaguucu gcuucagaau cagccccugc     1620

cuggcccagg accugaagca cuucaaggag cagauggaga gcaugaagca caacagaacc     1680

ugggaccugg aguucagccu guacgaggcc aagaucaaga accuggugaa gggcauccag     1740

augaacaacg ugagcuucaa gaucaagcac agcaacgaga agaagagcca gagccagaac     1800

cuguucagcg ugaagagcag ccugagccac ggccccaagg aggagcagaa gugccccagc     1860

gugcacggcc agaaggaggg caaggacaac aucgccggca cccagaagga ggccagcacc     1920

ggcaagggca gaggcaccga ggagaccccc aagaacaccu acaucuga                  1968


<210>  9031
<211>  1968
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP10__Homo_sapiens__AAI04958

<400>  9031
auggccaugg cuaaggccag aaaaccccgg gaggcgcugc ucugggcucu gagcgaccuu       60

gaagagaacg auuucaagaa acugaaguuu uaccuccgcg acaugacccu guccgaaggc      120

cagccuccgc uugccagagg ggagcuggaa ggacucaucc ccguggaucu ggccgagcug      180

cucauuucua aauauggcga gaaggaagcu gucaagguug ugcugaaagg gcuuaaggug      240

augaaucugc ucgagcuggu cgaccaacuu agccacaucu gccugcauga uuaccgggaa      300

guguaucgcg agcacguuag augucucgag gaauggcagg aggccggagu gaacggccgg      360

uacaaucagg uccugcuggu ggcuaaaccu uccucugaaa gccccgaguc ccucgccugc      420

ccuuuccccg aacaggagcu ggagucuguu acaguggaag cgcuuuuuga cagcggggag      480

aagccuuccc uggccccgag ccucgucgug cugcaaggau cugcuggcac gggcaaaacc      540

acacuugccc gcaagauggu gcuggauugg gcuaccggga cacucuaucc cggaagauuc      600

gacuacgucu uuuauguuuc cuguaaggaa guggugcugc ugcucgagag caaacuggaa      660

cagcuucugu ucuggugcug uggcgauaac caggccccug ucaccgagau ucuccggcag      720

cccgagcgcc ugcuuuuuau ccuggacggg uucgaugaac uccaaagacc uuuugaggaa      780

aagcugaaaa agcggggacu gucucccaaa gagucccucc ugcaucuucu gauucgcaga      840

cacacacucc cgaccugcag ccugcugauc acgacccggc cucuugcgcu ccgcaaucug      900

gaaccccugc ucaagcaggc cagacaugug cacauccugg gcuucucuga ggaggaacgg      960

gcuagauacu uuuccagcua cuucacagac gagaaacagg ccgaucgcgc uuuugacauu     1020

guucagaaga acgacauccu uuauaaggcc ugucaagugc cugggauuug cugggucgug     1080

uguuccuggc ugcagggaca gauggaacgg ggcaaaguug ugcucgagac ccccagaaau     1140

ucuacagaua ucuucauggc cuacgucagc accuuccugc ccccugacga ugacggcggg     1200

ugcuccgagc ugagccgcca ccgggugcuu agaucucucu guucccuggc ugcggaaggc     1260

auucaacauc agcgcuuucu guucgaggaa gccgagcucc ggaagcacaa ccuggaugga     1320

ccgagacuug cugccuuucu gagcucuaau gacuaucagc ucgggcuggc caucaaaaag     1380

uucuacagcu uucgccauau uuccuuccag gauuucuucc acgcuauguc uuaucugguc     1440

aaagaagacc aaagccggcu uggaaaggag uccagacgcg aggugcagcg gcuccuggaa     1500

guuaaggagc aggaaggcaa cgaugagaug acgcugacaa ugcaguuucu ccuggacauc     1560

agcaaaaagg auucuuucuc caaucuugaa cugaaauuuu gcuucagaau cagccccugc     1620

cucgcccaag accugaagca cuuuaaagag cagauggagu cuaugaagca uaaccggacc     1680

ugggaccugg aauuuucccu uuacgaggcg aagauuaaaa aucucgugaa ggggauccag     1740

augaacaaug ucagcuucaa aauuaagcac uccaacgaga aaaagucuca gagccaaaac     1800

cuguuuuccg ugaagucuag ccugucccau ggaccuaaag aagaacagaa gugucccagc     1860

guucacggcc agaaagaggg caaggauaau aucgcuggga cacagaaaga ggccucuacc     1920

ggaaagggcc gcgggaccga agagacaccu aaaaacacgu auauuuga                  1968


<210>  9032
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP11__Homo_sapiens__P59045

<400>  9032

Met Ala Glu Ser Asp Ser Thr Asp Phe Asp Leu Leu Trp Tyr Leu Glu 
1               5                   10                  15      


Asn Leu Ser Asp Lys Glu Phe Gln Ser Phe Lys Lys Tyr Leu Ala Arg 
            20                  25                  30          


Lys Ile Leu Asp Phe Lys Leu Pro Gln Phe Pro Leu Ile Gln Met Thr 
        35                  40                  45              


Lys Glu Glu Leu Ala Asn Val Leu Pro Ile Ser Tyr Glu Gly Gln Tyr 
    50                  55                  60                  


Ile Trp Asn Met Leu Phe Ser Ile Phe Ser Met Met Arg Lys Glu Asp 
65                  70                  75                  80  


Leu Cys Arg Lys Ile Ile Gly Arg Arg Asn Arg Asn Gln Glu Ala Cys 
                85                  90                  95      


Lys Ala Val Met Arg Arg Lys Phe Met Leu Gln Trp Glu Ser His Thr 
            100                 105                 110         


Phe Gly Lys Phe His Tyr Lys Phe Phe Arg Asp Val Ser Ser Asp Val 
        115                 120                 125             


Phe Tyr Ile Leu Gln Leu Ala Tyr Asp Ser Thr Ser Tyr Tyr Ser Ala 
    130                 135                 140                 


Asn Asn Leu Asn Val Phe Leu Met Gly Glu Arg Ala Ser Gly Lys Thr 
145                 150                 155                 160 


Ile Val Ile Asn Leu Ala Val Leu Arg Trp Ile Lys Gly Glu Met Trp 
                165                 170                 175     


Gln Asn Met Ile Ser Tyr Val Val His Leu Thr Ala His Glu Ile Asn 
            180                 185                 190         


Gln Met Thr Asn Ser Ser Leu Ala Glu Leu Ile Ala Lys Asp Trp Pro 
        195                 200                 205             


Asp Gly Gln Ala Pro Ile Ala Asp Ile Leu Ser Asp Pro Lys Lys Leu 
    210                 215                 220                 


Leu Phe Ile Leu Glu Asp Leu Asp Asn Ile Arg Phe Glu Leu Asn Val 
225                 230                 235                 240 


Asn Glu Ser Ala Leu Cys Ser Asn Ser Thr Gln Lys Val Pro Ile Pro 
                245                 250                 255     


Val Leu Leu Val Ser Leu Leu Lys Arg Lys Met Ala Pro Gly Cys Trp 
            260                 265                 270         


Phe Leu Ile Ser Ser Arg Pro Thr Arg Gly Asn Asn Val Lys Thr Phe 
        275                 280                 285             


Leu Lys Glu Val Asp Cys Cys Thr Thr Leu Gln Leu Ser Asn Gly Lys 
    290                 295                 300                 


Arg Glu Ile Tyr Phe Asn Ser Phe Phe Lys Asp Arg Gln Arg Ala Ser 
305                 310                 315                 320 


Ala Ala Leu Gln Leu Val His Glu Asp Glu Ile Leu Val Gly Leu Cys 
                325                 330                 335     


Arg Val Ala Ile Leu Cys Trp Ile Thr Cys Thr Val Leu Lys Arg Gln 
            340                 345                 350         


Met Asp Lys Gly Arg Asp Phe Gln Leu Cys Cys Gln Thr Pro Thr Asp 
        355                 360                 365             


Leu His Ala His Phe Leu Ala Asp Ala Leu Thr Ser Glu Ala Gly Leu 
    370                 375                 380                 


Thr Ala Asn Gln Tyr His Leu Gly Leu Leu Lys Arg Leu Cys Leu Leu 
385                 390                 395                 400 


Ala Ala Gly Gly Leu Phe Leu Ser Thr Leu Asn Phe Ser Gly Glu Asp 
                405                 410                 415     


Leu Arg Cys Val Gly Phe Thr Glu Ala Asp Val Ser Val Leu Gln Ala 
            420                 425                 430         


Ala Asn Ile Leu Leu Pro Ser Asn Thr His Lys Asp Arg Tyr Lys Phe 
        435                 440                 445             


Ile His Leu Asn Val Gln Glu Phe Cys Thr Ala Ile Ala Phe Leu Met 
    450                 455                 460                 


Ala Val Pro Asn Tyr Leu Ile Pro Ser Gly Ser Arg Glu Tyr Lys Glu 
465                 470                 475                 480 


Lys Arg Glu Gln Tyr Ser Asp Phe Asn Gln Val Phe Thr Phe Ile Phe 
                485                 490                 495     


Gly Leu Leu Asn Ala Asn Arg Arg Lys Ile Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Tyr Gln Leu Pro Met Val Asp Ser Phe Lys Trp Tyr Ser Val Gly Tyr 
        515                 520                 525             


Met Lys His Leu Asp Arg Asp Pro Glu Lys Leu Thr His His Met Pro 
    530                 535                 540                 


Leu Phe Tyr Cys Leu Tyr Glu Asn Arg Glu Glu Glu Phe Val Lys Thr 
545                 550                 555                 560 


Ile Val Asp Ala Leu Met Glu Val Thr Val Tyr Leu Gln Ser Asp Lys 
                565                 570                 575     


Asp Met Met Val Ser Leu Tyr Cys Leu Asp Tyr Cys Cys His Leu Arg 
            580                 585                 590         


Thr Leu Lys Leu Ser Val Gln Arg Ile Phe Gln Asn Lys Glu Pro Leu 
        595                 600                 605             


Ile Arg Pro Thr Ala Ser Gln Met Lys Ser Leu Val Tyr Trp Arg Glu 
    610                 615                 620                 


Ile Cys Ser Leu Phe Tyr Thr Met Glu Ser Leu Arg Glu Leu His Ile 
625                 630                 635                 640 


Phe Asp Asn Asp Leu Asn Gly Ile Ser Glu Arg Ile Leu Ser Lys Ala 
                645                 650                 655     


Leu Glu His Ser Ser Cys Lys Leu Arg Thr Leu Lys Leu Ser Tyr Val 
            660                 665                 670         


Ser Thr Ala Ser Gly Phe Glu Asp Leu Leu Lys Ala Leu Ala Arg Asn 
        675                 680                 685             


Arg Ser Leu Thr Tyr Leu Ser Ile Asn Cys Thr Ser Ile Ser Leu Asn 
    690                 695                 700                 


Met Phe Ser Leu Leu His Asp Ile Leu His Glu Pro Thr Cys Gln Ile 
705                 710                 715                 720 


Ser His Leu Ser Leu Met Lys Cys Asp Leu Arg Ala Ser Glu Cys Glu 
                725                 730                 735     


Glu Ile Ala Ser Leu Leu Ile Ser Gly Gly Ser Leu Arg Lys Leu Thr 
            740                 745                 750         


Leu Ser Ser Asn Pro Leu Arg Ser Asp Gly Met Asn Ile Leu Cys Asp 
        755                 760                 765             


Ala Leu Leu His Pro Asn Cys Thr Leu Ile Ser Leu Val Leu Val Phe 
    770                 775                 780                 


Cys Cys Leu Thr Glu Asn Cys Cys Ser Ala Leu Gly Arg Val Leu Leu 
785                 790                 795                 800 


Phe Ser Pro Thr Leu Arg Gln Leu Asp Leu Cys Val Asn Arg Leu Lys 
                805                 810                 815     


Asn Tyr Gly Val Leu His Val Thr Phe Pro Leu Leu Phe Pro Thr Cys 
            820                 825                 830         


Gln Leu Glu Glu Leu His Leu Ser Gly Cys Phe Phe Ser Ser Asp Ile 
        835                 840                 845             


Cys Gln Tyr Ile Ala Ile Val Ile Ala Thr Asn Glu Lys Leu Arg Ser 
    850                 855                 860                 


Leu Glu Ile Gly Ser Asn Lys Ile Glu Asp Ala Gly Met Gln Leu Leu 
865                 870                 875                 880 


Cys Gly Gly Leu Arg His Pro Asn Cys Met Leu Val Asn Ile Gly Leu 
                885                 890                 895     


Glu Glu Cys Met Leu Thr Ser Ala Cys Cys Arg Ser Leu Ala Ser Val 
            900                 905                 910         


Leu Thr Thr Asn Lys Thr Leu Glu Arg Leu Asn Leu Leu Gln Asn His 
        915                 920                 925             


Leu Gly Asn Asp Gly Val Ala Lys Leu Leu Glu Ser Leu Ile Ser Pro 
    930                 935                 940                 


Asp Cys Val Leu Lys Val Val Gly Leu Pro Leu Thr Gly Leu Asn Thr 
945                 950                 955                 960 


Gln Thr Gln Gln Leu Leu Met Thr Val Lys Glu Arg Lys Pro Ser Leu 
                965                 970                 975     


Ile Phe Leu Ser Glu Thr Trp Ser Leu Lys Glu Gly Arg Glu Ile Gly 
            980                 985                 990         


Val Thr Pro Ala Ser Gln Pro Gly Ser Ile Ile Pro Asn Ser Asn Leu 
        995                 1000                1005            


Asp Tyr Met Phe Phe Lys Phe Pro Arg Met Ser Ala Ala Met Arg Thr 
    1010                1015                1020                


Ser Asn Thr Ala Ser Arg Gln Pro Leu 
1025                1030            


<210>  9033
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP11__Homo_sapiens__CCDS12935.1

<400>  9033
auggcagaau cggauucuac ugacuuugac cugcuguggu aucuagagaa ucucagugac       60

aaggaauuuc agaguuuuaa gaaguaucug gcacgcaaga uucuugauuu caaacugcca      120

caguuuccac ugauacagau gacaaaagaa gaacuggcua acguguugcc aaucucuuau      180

gagggacagu auauauggaa uaugcucuuc agcauauuuu caaugaugcg uaaggaagau      240

cuuuguagga agaucauugg cagacgaaac cgcaaucagg aggcaugcaa agcugucaug      300

aggagaaaau ucaugcugca augggaaagu cacacuuuug gaaaauuuca uuauaaauuu      360

uuucgugacg uuucgucaga uguguucuac auacuucaau uagccuauga uucuaccagc      420

uauuauucag caaacaaucu caauguguuc cugaugggag agagagcauc uggaaaaacu      480

auuguuauaa aucuggcugu guugaggugg aucaagggug agauguggca gaacaugauc      540

ucguacgucg uucaccucac ugcucacgaa auaaaccaga ugaccaacag cagcuuggcu      600

gagcuaaucg ccaaggacug gccugacggc caggcuccca uugcagacau ccugucugau      660

cccaagaaac uccuuuucau ccucgaggac uuggacaaca uaagauucga guuaaauguc      720

aaugaaagug cuuuguguag uaacagcacc cagaaaguuc ccauuccagu ucuccugguc      780

aguuugcuga agagaaaaau ggcuccaggc ugcugguucc ucaucuccuc aaggcccaca      840

cgugggaaua auguaaaaac guucuugaaa gagguagauu gcugcacgac cuugcagcug      900

ucgaauggga agagggagau auauuuuaac ucuuucuuua aagaccgcca gagggcgucg      960

gcagcccucc agcuuguaca ugaggaugaa auacucgugg gucugugccg agucgccauc     1020

uuaugcugga ucacguguac uguccugaag cggcagaugg acaaggggcg ugacuuccag     1080

cucugcugcc aaacacccac ugaucuacau gcccacuuuc uugcugaugc guugacauca     1140

gaggcuggac uuacugccaa ucaguaucac cuaggucucc uaaaacgucu guguuugcug     1200

gcugcaggag gacuguuucu gagcacccug aauuucagug gugaagaccu cagauguguu     1260

ggguuuacug aggcugaugu cucuguguug caggccgcga auauucuuuu gccgagcaac     1320

acucauaaag accguuacaa guucauacac uugaacgucc aggaguuuug uacagccauu     1380

gcauuucuga uggcaguacc caacuaucug auccccucag gcagcagaga guauaaagag     1440

aagagagaac aauacucuga cuuuaaucaa guguuuacuu ucauuuuugg ucuucuaaau     1500

gcaaacagga gaaagauucu ugagacaucc uuuggauacc agcuaccgau gguagacagc     1560

uucaaguggu acucgguggg auacaugaaa cauuuggacc gugacccgga aaaguugacg     1620

caccauaugc cuuuguuuua cugucucuau gagaaucggg aagaagaauu ugugaagacg     1680

auuguggaug cucucaugga gguuacaguu uaccuucaau cagacaagga uaugaugguc     1740

ucauuauacu gucuggauua cugcugucac cugaggacac uuaaguugag uguucagcgc     1800

aucuuucaaa acaaagagcc acuuauaagg ccaacugcua gucaaaugaa gagccuuguc     1860

uacuggagag agaucugcuc ucuuuuuuau acaauggaga gccuccggga gcugcauauc     1920

uuugacaaug accuuaaugg uauuucagaa aggauucugu cuaaagcccu ggagcauucu     1980

agcuguaaac uucgcacacu caaguugucc uaugucucga cugcuucugg uuuugaagac     2040

uuacucaagg cuuuggcucg uaaucggagc cugacauacc ugaguaucaa cuguacgucc     2100

auuucccuaa auauguuuuc acuucugcau gacauccugc acgagcccac augccaaaua     2160

agucaucuga gcuugaugaa augugauuug cgagccagcg aaugugaaga aaucgccucu     2220

cuccucauca guggcgggag ucugagaaaa cugaccuuau ccagcaaucc gcugaggagc     2280

gacgggauga acauacugug ugaugccuug cuucauccca acugcacucu uauaucacug     2340

guguuagucu ucugcugucu cacugaaaau ugcugcagcg cccuuggaag agugcuucug     2400

uucagcccaa cucuaagaca acuagaccug ugugugaauc gcuuaaaaaa uuacggagug     2460

uugcauguga cguuucccuu gcuguuucca accugucagu uagaggagcu ucaucugucu     2520

ggcuguuucu uuagcagcga uaucugucaa uauauugcca uaguuauugc uacuaaugaa     2580

aaacugagga gccuggagau ugggagcaac aaaauagaag augcaggaau gcagcugcua     2640

uguggugguu ugagacaucc caacugcaug uuggugaaua uugggcuaga agagugcaug     2700

uuaaccagug ccugcugucg aucucuugcc ucuguucuua ccaccaacaa aacacuagaa     2760

agacucaacu ugcuucaaaa ucacuugggc aaugauggag uugcaaaacu ucuugagagc     2820

uugaucagcc cagauugugu acuuaaggua guugggcuuc cauuaacugg ccugaacaca     2880

caaacccagc aguugcugau gacuguaaag gaaagaaaac ccaguuugau cuuucugucu     2940

gaaacuuggu cuuuaaagga aggcagagaa auugguguga caccugcuuc ucagccaggu     3000

ucaauaauac cuaauucuaa uuuggauuac auguuuuuca aauuucccag aaugucugca     3060

gccaugagaa cgucaaauac agcaucuagg caaccccuuu ga                        3102


<210>  9034
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP11__Homo_sapiens__CCDS12935.1

<400>  9034
auggccgaga gcgacuccac cgacuucgac cugcucuggu accuggagaa ccugagcgac       60

aaggaguucc aguccuucaa gaaguaccuc gcccgcaaga uccuggacuu caagcugccc      120

caguucccgc ucauccagau gaccaaggag gagcuggcga acgugcugcc caucagcuac      180

gagggccagu acaucuggaa caugcuguuc uccaucuuca gcaugaugcg gaaggaggac      240

cugugccgca agaucaucgg gcggcgcaac cggaaccagg aggccugcaa ggccgucaug      300

cgccggaagu ucaugcugca gugggagucc cacacguucg gcaaguucca cuacaaguuc      360

uuccgcgacg ugagcuccga cguguucuac auccuccagc uggccuacga cagcaccucc      420

uacuacagcg ccaacaaccu gaacgucuuc cucauggggg agcgggcguc cggcaagacc      480

aucgugauca accuggccgu gcugcgcugg aucaaggggg agauguggca gaacaugauc      540

agcuacgucg ugcaccucac cgcccacgag aucaaccaga ugacgaacuc cagccuggcc      600

gagcugaucg cgaaggacug gcccgacggc caggccccca ucgccgacau ccucuccgac      660

ccgaagaagc ugcuguucau ccucgaggac cuggacaaca uccgguucga gcugaacgug      720

aacgagagcg cccucugcuc caacagcacc cagaaggucc ccauccccgu gcugcuggug      780

agccuccuga agcgcaagau ggcccccggc ugcugguucc ugaucuccag ccggccgacc      840

cgcgggaaca acgucaagac cuuccucaag gagguggacu gcugcacgac ccugcagcug      900

uccaacggca agcgggagau cuacuucaac agcuucuuca aggaccgcca gcgggcgucc      960

gccgcccucc agcuggugca cgaggacgag auccuggucg ggcucugccg cguggccauc     1020

cugugcugga ucacgugcac cgugcugaag cggcagaugg acaagggccg cgacuuccag     1080

cucugcugcc agacccccac cgaccugcac gcccacuucc uggcggacgc ccucaccagc     1140

gaggccgggc ugaccgccaa ccaguaccac cugggccucc ugaagcggcu gugccugcuc     1200

gccgcgggcg ggcuguuccu guccacgcuc aacuucagcg gcgaggaccu gcgcugcguc     1260

ggguucaccg aggccgacgu guccgugcug caggccgcca acauccuccu gcccagcaac     1320

acccacaagg accgcuacaa guucauccac cugaacgucc aggaguucug caccgccauc     1380

gcguuccuca uggccgugcc caacuaccug aucccguccg gcagccggga guacaaggag     1440

aagcgcgagc aguacuccga cuucaaccag guguucacgu ucaucuucgg ccugcucaac     1500

gccaaccggc gcaagauccu ggagaccagc uucggguacc agcugcccau ggucgacucc     1560

uucaaguggu acagcguggg cuacaugaag caccucgacc gggaccccga gaagcugacc     1620

caccacaugc cccuguucua cugccucuac gagaaccgcg aggaggaguu cgucaagacc     1680

aucguggacg cccugaugga ggugacgguc uaccugcagu ccgacaagga caugauggug     1740

agccucuacu gccuggacua cugcugccac cuccggaccc ucaagcuguc cgugcagcgc     1800

aucuuccaga acaaggagcc gcugauccgg cccaccgcga gccagaugaa gucccucguc     1860

uacuggcgcg agaucugcag ccuguucuac accauggaga gccugcggga gcuccacauc     1920

uucgacaacg accugaacgg gaucuccgag cgcauccuga gcaaggcccu cgagcacucc     1980

agcugcaagc ugcggacgcu gaagcucucc uacgugagca ccgccuccgg cuucgaggac     2040

cugcugaagg cccucgcccg caaccggagc cugaccuacc uguccaucaa cugcaccagc     2100

aucucccuca acauguucag ccugcugcac gacauccucc acgagcccac gugccagauc     2160

ucccaccuga gccugaugaa gugcgaccuc cgcgcguccg agugcgagga gaucgccagc     2220

cugcugauca gcgggggcuc ccuccggaag cugacccuga gcuccaaccc ccuccgcagc     2280

gacggcauga acauccugug cgacgcccug cuccacccga acugcacccu gaucucccug     2340

gugcucgucu ucugcugccu gaccgagaac ugcugcagcg cccuggggcg ggugcuccug     2400

uucuccccca cgcugcgcca gcucgaccug ugcgugaacc gccugaagaa cuacggcguc     2460

cuccacguga ccuucccccu gcuguucccg accugccagc ucgaggagcu gcaccugagc     2520

gggugcuucu ucuccagcga caucugccag uacaucgcca ucgugaucgc gaccaacgag     2580

aagcuccggu cccuggagau cggcagcaac aagaucgagg acgccgggau gcagcugcuc     2640

ugcggcggcc ugcgccaccc caacugcaug cuggucaaca ucgggcucga ggagugcaug     2700

cugaccuccg ccugcugccg gagccuggcc uccgugcuca cgaccaacaa gacccuggag     2760

cgccugaacc uccugcagaa ccaccugggc aacgacgggg uggccaagcu ccuggagagc     2820

cugaucuccc ccgacugcgu ccucaaggug gugggccugc cccugaccgg gcugaacacg     2880

cagacccagc agcuccugau gaccgucaag gagcggaagc ccagccugau cuuccucucc     2940

gagaccugga gccugaagga gggccgcgag aucggcguga cgccggcgag ccagcccggg     3000

uccaucaucc ccaacagcaa ccuggacuac auguucuuca aguucccgcg gauguccgcc     3060

gccaugcgca ccagcaacac cgccucccgg cagccccucu ga                        3102


<210>  9035
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP11__Homo_sapiens__CCDS12935.1

<400>  9035
auggccgagu ccgacuccac cgacuucgac cuccucuggu accucgagaa ccucuccgac       60

aaggaguucc aguccuucaa gaaguaccuc gcccgcaaga uccucgacuu caagcucccc      120

caguuccccc ucauccagau gaccaaggag gagcucgcca acguccuccc caucuccuac      180

gagggccagu acaucuggaa caugcucuuc uccaucuucu ccaugaugcg caaggaggac      240

cucugccgca agaucaucgg ccgccgcaac cgcaaccagg aggccugcaa ggccgucaug      300

cgccgcaagu ucaugcucca gugggagucc cacaccuucg gcaaguucca cuacaaguuc      360

uuccgcgacg ucuccuccga cgucuucuac auccuccagc ucgccuacga cuccaccucc      420

uacuacuccg ccaacaaccu caacgucuuc cucaugggcg agcgcgccuc cggcaagacc      480

aucgucauca accucgccgu ccuccgcugg aucaagggcg agauguggca gaacaugauc      540

uccuacgucg uccaccucac cgcccacgag aucaaccaga ugaccaacuc cucccucgcc      600

gagcucaucg ccaaggacug gcccgacggc caggccccca ucgccgacau ccucuccgac      660

cccaagaagc uccucuucau ccucgaggac cucgacaaca uccgcuucga gcucaacguc      720

aacgaguccg cccucugcuc caacuccacc cagaaggucc ccauccccgu ccuccucguc      780

ucccuccuca agcgcaagau ggcccccggc ugcugguucc ucaucuccuc ccgccccacc      840

cgcggcaaca acgucaagac cuuccucaag gaggucgacu gcugcaccac ccuccagcuc      900

uccaacggca agcgcgagau cuacuucaac uccuucuuca aggaccgcca gcgcgccucc      960

gccgcccucc agcucgucca cgaggacgag auccucgucg gccucugccg cgucgccauc     1020

cucugcugga ucaccugcac cguccucaag cgccagaugg acaagggccg cgacuuccag     1080

cucugcugcc agacccccac cgaccuccac gcccacuucc ucgccgacgc ccucaccucc     1140

gaggccggcc ucaccgccaa ccaguaccac cucggccucc ucaagcgccu cugccuccuc     1200

gccgccggcg gccucuuccu cuccacccuc aacuucuccg gcgaggaccu ccgcugcguc     1260

ggcuucaccg aggccgacgu cuccguccuc caggccgcca acauccuccu ccccuccaac     1320

acccacaagg accgcuacaa guucauccac cucaacgucc aggaguucug caccgccauc     1380

gccuuccuca uggccguccc caacuaccuc auccccuccg gcucccgcga guacaaggag     1440

aagcgcgagc aguacuccga cuucaaccag gucuucaccu ucaucuucgg ccuccucaac     1500

gccaaccgcc gcaagauccu cgagaccucc uucggcuacc agcuccccau ggucgacucc     1560

uucaaguggu acuccgucgg cuacaugaag caccucgacc gcgaccccga gaagcucacc     1620

caccacaugc cccucuucua cugccucuac gagaaccgcg aggaggaguu cgucaagacc     1680

aucgucgacg cccucaugga ggucaccguc uaccuccagu ccgacaagga caugaugguc     1740

ucccucuacu gccucgacua cugcugccac cuccgcaccc ucaagcucuc cguccagcgc     1800

aucuuccaga acaaggagcc ccucauccgc cccaccgccu cccagaugaa gucccucguc     1860

uacuggcgcg agaucugcuc ccucuucuac accauggagu cccuccgcga gcuccacauc     1920

uucgacaacg accucaacgg caucuccgag cgcauccucu ccaaggcccu cgagcacucc     1980

uccugcaagc uccgcacccu caagcucucc uacgucucca ccgccuccgg cuucgaggac     2040

cuccucaagg cccucgcccg caaccgcucc cucaccuacc ucuccaucaa cugcaccucc     2100

aucucccuca acauguucuc ccuccuccac gacauccucc acgagcccac cugccagauc     2160

ucccaccucu cccucaugaa gugcgaccuc cgcgccuccg agugcgagga gaucgccucc     2220

cuccucaucu ccggcggcuc ccuccgcaag cucacccucu ccuccaaccc ccuccgcucc     2280

gacggcauga acauccucug cgacgcccuc cuccacccca acugcacccu caucucccuc     2340

guccucgucu ucugcugccu caccgagaac ugcugcuccg cccucggccg cguccuccuc     2400

uucuccccca cccuccgcca gcucgaccuc ugcgucaacc gccucaagaa cuacggcguc     2460

cuccacguca ccuucccccu ccucuucccc accugccagc ucgaggagcu ccaccucucc     2520

ggcugcuucu ucuccuccga caucugccag uacaucgcca ucgucaucgc caccaacgag     2580

aagcuccgcu cccucgagau cggcuccaac aagaucgagg acgccggcau gcagcuccuc     2640

ugcggcggcc uccgccaccc caacugcaug cucgucaaca ucggccucga ggagugcaug     2700

cucaccuccg ccugcugccg cucccucgcc uccguccuca ccaccaacaa gacccucgag     2760

cgccucaacc uccuccagaa ccaccucggc aacgacggcg ucgccaagcu ccucgagucc     2820

cucaucuccc ccgacugcgu ccucaagguc gucggccucc cccucaccgg ccucaacacc     2880

cagacccagc agcuccucau gaccgucaag gagcgcaagc ccucccucau cuuccucucc     2940

gagaccuggu cccucaagga gggccgcgag aucggcguca cccccgccuc ccagcccggc     3000

uccaucaucc ccaacuccaa ccucgacuac auguucuuca aguucccccg cauguccgcc     3060

gccaugcgca ccuccaacac cgccucccgc cagccccucu ga                        3102


<210>  9036
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP11__Homo_sapiens__CCDS12935.1

<400>  9036
auggccgaga gcgacuccac cgauuucgac cugcucuggu accuugaaaa ccugucugau       60

aaggaguuuc agucauucaa aaaguauuug gcuagaaaaa ucuuagacuu uaagcugccc      120

caauucccuc uaauucagau gacaaaagaa gaacucgcaa augugcugcc aauaaguuac      180

gaaggccagu auaucuggaa caugcuuuuu agcauuuucu ccaugaugag gaaggaggau      240

cugugccgga agaucauugg gcgccgaaau cguaaccagg aggccuguaa agcggucaug      300

agaaggaagu uuauguugca augggaaucu cacacuuucg gaaaauuuca uuacaaguuc      360

uuucgggacg uuucgucaga uguguucuau auccuccagc uggcuuacga cagcacgagu      420

uauuacuccg ccaauaaccu gaauguauuu cucaugggug agcgcgcauc uggcaaaacc      480

auagugauca acuuagccgu ccugagaugg auuaaggggg aaauguggca gaauaugauc      540

agcuacgugg uucaccuuac agcucaugag auuaaccaga ugacuaauuc cucauuggca      600

gagcugaucg ccaaggauug gccggacgga caagcuccca uagccgauau ucuaagugac      660

ccuaaaaagc uccuguucau ccuugaagau cuggacaaca uuagguucga guugaaugug      720

aacgaaagcg cgcucugcuc uaauuccacc cagaaagucc caauccccgu gcuguuagua      780

ucacugcuca agcggaaaau ggcaccuggc uguugguuuc uuaucagcag ucgcccaaca      840

cgagguaaca acguuaagac cuuccugaaa gagguggacu gcuguacuac auugcagcua      900

ucuaauggga agagagaaau uuauuuuaac uccuucuuua aggauaggca gcgggccagc      960

gcugcccugc aacucgucca cgaggacgag auacuggugg gacuuugccg uguggcaauc     1020

cuguguugga uuaccugcac ggucuugaaa cgccagaugg auaagggcag agacuuccag     1080

cucuguugcc aaacucccac cgaucugcau gcucacuuuu uagccgacgc gcugacaucg     1140

gaagccggcc uaacugcaaa ucaguaccac cucgggcugc uuaaaagguu gugucugcuc     1200

gcugccggag gucuguuccu uucuacccug aacuuuuccg gcgaggauuu gcggugcguu     1260

ggguucacag aagcugacgu gucaguacuc caggccgcaa auauccuguu accuaguaac     1320

acccauaagg aucgauauaa auuuauacac cugaaugugc aggaguucug cacggccauu     1380

gcuuuucuaa uggcgguccc aaacuaccuc aucccgagcg gaucccgcga auauaaggag     1440

aagagagagc aauacucuga cuucaaucag guguucacuu uuaucuucgg ccugcuuaac     1500

gcaaauaggc ggaaaauuuu ggaaaccagc uuugguuauc agcugcccau gguugauuca     1560

uucaaguggu acaguguggg guacaugaaa caucucgacc gcgacccuga gaagcugaca     1620

caccacaugc cauuauuuua uugucuguac gaaaacagag aggaagaguu cgucaaaacu     1680

aucguggaug cccuuaugga gguaacaguu uauuugcagu ccgacaagga uaugauggug     1740

agccucuacu gccuggacua uuguugccau cuaaggaccc ugaagcucuc uguccaacgu     1800

auuuuucaga auaaagaacc ccugauacgg ccuacggcuu cacagaugaa gagucuugug     1860

uacuggcgag agaucuguag cuuguucuau accauggaau cccugagaga guuacacauu     1920

uuugauaacg accucaaugg aaucucugag aggauccugu cgaaagcccu ugaacauagc     1980

uccugcaagc ugcgcacauu gaaacucuca uacgucagua cugcaucugg cuucgaggau     2040

cugcuaaagg cccuggcucg gaacagaagc cucaccuacc uguccauuaa cuguacauca     2100

auaagccuua auauguuuuc uuugcugcac gacaucuuac augaaccaac uugccagauu     2160

ucccaccuca gucugaugaa gugugaucuu agggccagcg agugcgaaga gaucgcaucu     2220

cugcuaauuu ccggcggguc acuccgcaaa cugaccuuga guagcaaccc ccugcgaucg     2280

gacggaauga auaucuuaug ugaugcgcuc cugcacccga acugcacacu uauaucccug     2340

guguugguuu ucugcugucu caccgagaau ugcuguucug cucugggucg ggugcuacug     2400

uuuagcccua cucuucguca acucgaccug ugcguaaaca gauugaagaa uuauggcguc     2460

cugcauguga cguuccccuu acucuuccca acaugucagc uggaggagcu ucaccuguca     2520

gggugcuuuu ucaguuccga uaucugucag uacauugcca ucguuauugc aaccaacgaa     2580

aaauugaggu cucucgagau cggaagcaau aagauagaag acgccggcau gcagcugcua     2640

ugcggugggc ugcgccaucc uaacuguaug cuugugaaua uuggccucga ggagugcaug     2700

cugacuuccg cuuguugccg gucauuggcc agcgucuuaa ccacaaacaa aacccuggaa     2760

agacucaauc ugcuucaaaa ccaccuggga aaugacggcg uggcaaaguu gcuagagagu     2820

cugaucucuc ccgauugcgu acucaaagug guugggcugc cacuuacugg auuaaacaca     2880

cagacgcagc aacugcucau gaccgucaag gaaaggaagc ccuccuugau uuuucugagc     2940

gagacuuggu cgcucaaaga aggucgagag aucggcguga ccccugcuuc acagccaggg     3000

ucuauaaucc cgaacaguaa ucuggacuau auguucuuua aguucccccg cauguccgcc     3060

gcgaugcgga caagcaacac agccucuaga cagccucuuu ga                        3102


<210>  9037
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP11__Homo_sapiens__CCDS12935.1

<400>  9037
auggccgaga gcgacagcac cgacuucgac cugcuguggu accuggagaa ccugagcgac       60

aaggaguucc agagcuucaa gaaguaccug gccagaaaga uccuggacuu caagcugccc      120

caguuccccc ugauccagau gaccaaggag gagcuggcca acgugcugcc caucagcuac      180

gagggccagu acaucuggaa caugcuguuc agcaucuuca gcaugaugag aaaggaggac      240

cugugcagaa agaucaucgg cagaagaaac agaaaccagg aggccugcaa ggccgugaug      300

agaagaaagu ucaugcugca gugggagagc cacaccuucg gcaaguucca cuacaaguuc      360

uucagagacg ugagcagcga cguguucuac auccugcagc uggccuacga cagcaccagc      420

uacuacagcg ccaacaaccu gaacguguuc cugaugggcg agagagccag cggcaagacc      480

aucgugauca accuggccgu gcugagaugg aucaagggcg agauguggca gaacaugauc      540

agcuacgugg ugcaccugac cgcccacgag aucaaccaga ugaccaacag cagccuggcc      600

gagcugaucg ccaaggacug gcccgacggc caggccccca ucgccgacau ccugagcgac      660

cccaagaagc ugcuguucau ccuggaggac cuggacaaca ucagauucga gcugaacgug      720

aacgagagcg cccugugcag caacagcacc cagaaggugc ccauccccgu gcugcuggug      780

agccugcuga agagaaagau ggcccccggc ugcugguucc ugaucagcag cagacccacc      840

agaggcaaca acgugaagac cuuccugaag gagguggacu gcugcaccac ccugcagcug      900

agcaacggca agagagagau cuacuucaac agcuucuuca aggacagaca gagagccagc      960

gccgcccugc agcuggugca cgaggacgag auccuggugg gccugugcag aguggccauc     1020

cugugcugga ucaccugcac cgugcugaag agacagaugg acaagggcag agacuuccag     1080

cugugcugcc agacccccac cgaccugcac gcccacuucc uggccgacgc ccugaccagc     1140

gaggccggcc ugaccgccaa ccaguaccac cugggccugc ugaagagacu gugccugcug     1200

gccgccggcg gccuguuccu gagcacccug aacuucagcg gcgaggaccu gagaugcgug     1260

ggcuucaccg aggccgacgu gagcgugcug caggccgcca acauccugcu gcccagcaac     1320

acccacaagg acagauacaa guucauccac cugaacgugc aggaguucug caccgccauc     1380

gccuuccuga uggccgugcc caacuaccug auccccagcg gcagcagaga guacaaggag     1440

aagagagagc aguacagcga cuucaaccag guguucaccu ucaucuucgg ccugcugaac     1500

gccaacagaa gaaagauccu ggagaccagc uucggcuacc agcugcccau gguggacagc     1560

uucaaguggu acagcguggg cuacaugaag caccuggaca gagaccccga gaagcugacc     1620

caccacaugc cccuguucua cugccuguac gagaacagag aggaggaguu cgugaagacc     1680

aucguggacg cccugaugga ggugaccgug uaccugcaga gcgacaagga caugauggug     1740

agccuguacu gccuggacua cugcugccac cugagaaccc ugaagcugag cgugcagaga     1800

aucuuccaga acaaggagcc ccugaucaga cccaccgcca gccagaugaa gagccuggug     1860

uacuggagag agaucugcag ccuguucuac accauggaga gccugagaga gcugcacauc     1920

uucgacaacg accugaacgg caucagcgag agaauccuga gcaaggcccu ggagcacagc     1980

agcugcaagc ugagaacccu gaagcugagc uacgugagca ccgccagcgg cuucgaggac     2040

cugcugaagg cccuggccag aaacagaagc cugaccuacc ugagcaucaa cugcaccagc     2100

aucagccuga acauguucag ccugcugcac gacauccugc acgagcccac cugccagauc     2160

agccaccuga gccugaugaa gugcgaccug agagccagcg agugcgagga gaucgccagc     2220

cugcugauca gcggcggcag ccugagaaag cugacccuga gcagcaaccc ccugagaagc     2280

gacggcauga acauccugug cgacgcccug cugcacccca acugcacccu gaucagccug     2340

gugcuggugu ucugcugccu gaccgagaac ugcugcagcg cccugggcag agugcugcug     2400

uucagcccca cccugagaca gcuggaccug ugcgugaaca gacugaagaa cuacggcgug     2460

cugcacguga ccuucccccu gcuguucccc accugccagc uggaggagcu gcaccugagc     2520

ggcugcuucu ucagcagcga caucugccag uacaucgcca ucgugaucgc caccaacgag     2580

aagcugagaa gccuggagau cggcagcaac aagaucgagg acgccggcau gcagcugcug     2640

ugcggcggcc ugagacaccc caacugcaug cuggugaaca ucggccugga ggagugcaug     2700

cugaccagcg ccugcugcag aagccuggcc agcgugcuga ccaccaacaa gacccuggag     2760

agacugaacc ugcugcagaa ccaccugggc aacgacggcg uggccaagcu gcuggagagc     2820

cugaucagcc ccgacugcgu gcugaaggug gugggccugc cccugaccgg ccugaacacc     2880

cagacccagc agcugcugau gaccgugaag gagagaaagc ccagccugau cuuccugagc     2940

gagaccugga gccugaagga gggcagagag aucggcguga cccccgccag ccagcccggc     3000

agcaucaucc ccaacagcaa ccuggacuac auguucuuca aguuccccag aaugagcgcc     3060

gccaugagaa ccagcaacac cgccagcaga cagccccugu ga                        3102


<210>  9038
<211>  3102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP11__Homo_sapiens__CCDS12935.1

<400>  9038
auggccgaga gcgacuccac cgauuucgac cugcucuggu accuggaaaa ccuuucugau       60

aaggaguuuc agagcuucaa aaaguaucug gcuagaaaaa uccucgacuu uaagcugccc      120

caauucccuc uuauucagau gacaaaagaa gaacuggcca augugcuccc gaucuccuac      180

gaaggccagu auauuuggaa caugcuguuu ucuaucuuca gcaugaugcg gaaggaggau      240

cugugccgca agauuaucgg gagacggaau cgcaaccagg aggcguguaa agcugucaug      300

agacggaagu uuaugcucca augggaaucc cacacguucg gaaaauuuca uuacaaguuc      360

uuucgcgacg uuucuagcga uguguucuau auccugcagc uugccuacga cuccaccagc      420

uauuacucug ccaauaaccu gaauguguuu cucaugggcg agagagcuuc cgggaaaaca      480

auugucauca accuggccgu gcuucggugg auuaagggag aaauguggca gaauaugauc      540

agcuacguug ugcaccugac cgcucaugag auuaaccaga ugacaaauuc uucccucgcc      600

gagcugaucg cgaaggauug gcccgacggc caagccccua uugcugauau ccugagcgac      660

cccaaaaagc uccuguucau ccuugaagau cuggacaaca uucgcuucga gcucaauguc      720

aacgaaucug cccugugcuc caauagcacc cagaaagugc cuauccccgu ucuucuggug      780

ucccuccuga agagaaaaau ggcuccuggg uguugguuuc ugauuucuag ccggccgaca      840

cgcggaaaca acgucaagac cuuccucaaa gagguggacu gcuguacgac ccugcagcuu      900

uccaauggca agagagaaau cuauuuuaac agcuucuuua aggaucggca gcgcgccucu      960

gcggcccugc aacucgugca cgaggacgag auucuggucg gccuuugcag aguugcuauc     1020

cuguguugga ucacaugcac cgugcucaaa cggcagaugg auaaggggag agacuuccag     1080

cuguguugcc aaacacccac cgaucugcau gcccacuuuc ucgcugacgc ccugacgucc     1140

gaagccggac uuacagcuaa ucaguaccac cugggccucc ugaaacgccu gugucuucuc     1200

gcggccgggg gacuguuccu gagcacccuc aacuuuucug gcgaggaucu gcggugcgug     1260

ggguucacag aagcugacgu cagcgugcuu caggccgcca auauucugcu cccuuccaac     1320

acccauaagg auagauauaa auuuauccac cugaauguuc aggaguucug caccgcuauu     1380

gccuuucuga uggcggugcc caacuaccuu aucccuucug gaagccgcga auauaaggag     1440

aagcgggagc aauacuccga cuucaaucag gucuucacau uuauuuucgg ccuccugaac     1500

gcuaauagac gcaaaauccu ggaaacgagc uuuggcuauc agcuccccau gguggauucu     1560

uucaaguggu acuccguugg guacaugaaa caucuggacc gggacccgga gaaacuuacc     1620

caccacaugc cucuguuuua uugucucuac gaaaacagag aggaagaguu cgugaagaca     1680

aucgucgaug cccugaugga ggugaccguc uaucugcaga gcgacaagga uaugauggug     1740

ucucuuuacu gccucgacua uuguugccau cugcgcacac ugaagcucuc cguucaacgg     1800

auuuuucaga auaaagaacc ccugaucaga ccuaccgcca gccagaugaa gucccuugug     1860

uacuggcgcg agauuuguuc ucuguucuau acgauggaaa gccuccggga gcugcacauc     1920

uuugauaacg accugaaugg aauuuccgag agaauccuuu cuaaagcucu cgaacauagc     1980

uccugcaagc ugcggacacu gaaacucagc uacgucucua ccgccuccgg cuucgaggau     2040

cugcuuaagg cucuggcccg caacagaagc cucaccuacc ugucuauuaa cuguacaucc     2100

aucagccuga auauguuuuc ucuucugcac gacauccucc augaacccac augccagauu     2160

agccaccugu cccucaugaa gugugaucug cgggcgagcg agugcgaaga gaucgccucu     2220

cuucugauuu ccgggggaag ccucagaaaa cugacacugu ccucuaaccc ccuucgcagc     2280

gacggcauga auauccugug ugaugcucuc cugcacccua acugcacgcu cauuucccug     2340

gugcuuguuu ucugcugucu gaccgagaau ugcuguucug cccucgggcg ggugcugcug     2400

uuuagcccga cacuuagaca acuggaccuc ugcgucaacc gccugaagaa uuauggagug     2460

cuccauguga ccuucccccu gcuuuucccu acaugucagc uggaggagcu gcaccucucc     2520

ggcugcuuuu ucucuagcga uaucugucag uacaucgcua uuguuaucgc caccaacgaa     2580

aaacugagau cccuugagau uggcagcaau aagaucgaag acgcggggau gcagcugcuc     2640

ugcggaggcc ugcggcaucc caacuguaug cucgucaaua uugggcugga ggagugcaug     2700

cuuacgucug ccuguugccg cucccuggcu agcgugcuga ccacaaacaa aacccucgaa     2760

agacugaauc uucugcaaaa ccaccucgga aaugacggcg uggccaagcu gcucgagucu     2820

cugaucuccc cugauugcgu ccuuaaagug guugggcugc cccugacagg ccucaacacc     2880

cagacgcagc aacugcuuau gacagugaag gaacggaagc cgagccugau cuuucucucu     2940

gagaccuggu cccugaaaga aggacgcgag auuggcguca ccccugcuag ccagcccggg     3000

uccaucauuc cuaacagcaa ucucgacuau auguucuuua aguuccccag aaugucugcc     3060

gccaugcgga ccagcaacac cgcuucccgc cagccucugu ga                        3102


<210>  9039
<211>  1061
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP12__Homo_sapiens__P59046

<400>  9039

Met Leu Arg Thr Ala Gly Arg Asp Gly Leu Cys Arg Leu Ser Thr Tyr 
1               5                   10                  15      


Leu Glu Glu Leu Glu Ala Val Glu Leu Lys Lys Phe Lys Leu Tyr Leu 
            20                  25                  30          


Gly Thr Ala Thr Glu Leu Gly Glu Gly Lys Ile Pro Trp Gly Ser Met 
        35                  40                  45              


Glu Lys Ala Gly Pro Leu Glu Met Ala Gln Leu Leu Ile Thr His Phe 
    50                  55                  60                  


Gly Pro Glu Glu Ala Trp Arg Leu Ala Leu Ser Thr Phe Glu Arg Ile 
65                  70                  75                  80  


Asn Arg Lys Asp Leu Trp Glu Arg Gly Gln Arg Glu Asp Leu Val Arg 
                85                  90                  95      


Asp Thr Pro Pro Gly Gly Pro Ser Ser Leu Gly Asn Gln Ser Thr Cys 
            100                 105                 110         


Leu Leu Glu Val Ser Leu Val Thr Pro Arg Lys Asp Pro Gln Glu Thr 
        115                 120                 125             


Tyr Arg Asp Tyr Val Arg Arg Lys Phe Arg Leu Met Glu Asp Arg Asn 
    130                 135                 140                 


Ala Arg Leu Gly Glu Cys Val Asn Leu Ser His Arg Tyr Thr Arg Leu 
145                 150                 155                 160 


Leu Leu Val Lys Glu His Ser Asn Pro Met Gln Val Gln Gln Gln Leu 
                165                 170                 175     


Leu Asp Thr Gly Arg Gly His Ala Arg Thr Val Gly His Gln Ala Ser 
            180                 185                 190         


Pro Ile Lys Ile Glu Thr Leu Phe Glu Pro Asp Glu Glu Arg Pro Glu 
        195                 200                 205             


Pro Pro Arg Thr Val Val Met Gln Gly Ala Ala Gly Ile Gly Lys Ser 
    210                 215                 220                 


Met Leu Ala His Lys Val Met Leu Asp Trp Ala Asp Gly Lys Leu Phe 
225                 230                 235                 240 


Gln Gly Arg Phe Asp Tyr Leu Phe Tyr Ile Asn Cys Arg Glu Met Asn 
                245                 250                 255     


Gln Ser Ala Thr Glu Cys Ser Met Gln Asp Leu Ile Phe Ser Cys Trp 
            260                 265                 270         


Pro Glu Pro Ser Ala Pro Leu Gln Glu Leu Ile Arg Val Pro Glu Arg 
        275                 280                 285             


Leu Leu Phe Ile Ile Asp Gly Phe Asp Glu Leu Lys Pro Ser Phe His 
    290                 295                 300                 


Asp Pro Gln Gly Pro Trp Cys Leu Cys Trp Glu Glu Lys Arg Pro Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Asn Ser Leu Ile Arg Lys Lys Leu Leu Pro Glu Leu 
                325                 330                 335     


Ser Leu Leu Ile Thr Thr Arg Pro Thr Ala Leu Glu Lys Leu His Arg 
            340                 345                 350         


Leu Leu Glu His Pro Arg His Val Glu Ile Leu Gly Phe Ser Glu Ala 
        355                 360                 365             


Glu Arg Lys Glu Tyr Phe Tyr Lys Tyr Phe His Asn Ala Glu Gln Ala 
    370                 375                 380                 


Gly Gln Val Phe Asn Tyr Val Arg Asp Asn Glu Pro Leu Phe Thr Met 
385                 390                 395                 400 


Cys Phe Val Pro Leu Val Cys Trp Val Val Cys Thr Cys Leu Gln Gln 
                405                 410                 415     


Gln Leu Glu Gly Gly Gly Leu Leu Arg Gln Thr Ser Arg Thr Thr Thr 
            420                 425                 430         


Ala Val Tyr Met Leu Tyr Leu Leu Ser Leu Met Gln Pro Lys Pro Gly 
        435                 440                 445             


Ala Pro Arg Leu Gln Pro Pro Pro Asn Gln Arg Gly Leu Cys Ser Leu 
    450                 455                 460                 


Ala Ala Asp Gly Leu Trp Asn Gln Lys Ile Leu Phe Glu Glu Gln Asp 
465                 470                 475                 480 


Leu Arg Lys His Gly Leu Asp Gly Glu Asp Val Ser Ala Phe Leu Asn 
                485                 490                 495     


Met Asn Ile Phe Gln Lys Asp Ile Asn Cys Glu Arg Tyr Tyr Ser Phe 
            500                 505                 510         


Ile His Leu Ser Phe Gln Glu Phe Phe Ala Ala Met Tyr Tyr Ile Leu 
        515                 520                 525             


Asp Glu Gly Glu Gly Gly Ala Gly Pro Asp Gln Asp Val Thr Arg Leu 
    530                 535                 540                 


Leu Thr Glu Tyr Ala Phe Ser Glu Arg Ser Phe Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Arg Phe Leu Phe Gly Leu Leu Asn Glu Glu Thr Arg Ser His Leu Glu 
                565                 570                 575     


Lys Ser Leu Cys Trp Lys Val Ser Pro His Ile Lys Met Asp Leu Leu 
            580                 585                 590         


Gln Trp Ile Gln Ser Lys Ala Gln Ser Asp Gly Ser Thr Leu Gln Gln 
        595                 600                 605             


Gly Ser Leu Glu Phe Phe Ser Cys Leu Tyr Glu Ile Gln Glu Glu Glu 
    610                 615                 620                 


Phe Ile Gln Gln Ala Leu Ser His Phe Gln Val Ile Val Val Ser Asn 
625                 630                 635                 640 


Ile Ala Ser Lys Met Glu His Met Val Ser Ser Phe Cys Leu Lys Arg 
                645                 650                 655     


Cys Arg Ser Ala Gln Val Leu His Leu Tyr Gly Ala Thr Tyr Ser Ala 
            660                 665                 670         


Asp Gly Glu Asp Arg Ala Arg Cys Ser Ala Gly Ala His Thr Leu Leu 
        675                 680                 685             


Val Gln Leu Pro Glu Arg Thr Val Leu Leu Asp Ala Tyr Ser Glu His 
    690                 695                 700                 


Leu Ala Ala Ala Leu Cys Thr Asn Pro Asn Leu Ile Glu Leu Ser Leu 
705                 710                 715                 720 


Tyr Arg Asn Ala Leu Gly Ser Arg Gly Val Lys Leu Leu Cys Gln Gly 
                725                 730                 735     


Leu Arg His Pro Asn Cys Lys Leu Gln Asn Leu Arg Leu Lys Arg Cys 
            740                 745                 750         


Arg Ile Ser Ser Ser Ala Cys Glu Asp Leu Ser Ala Ala Leu Ile Ala 
        755                 760                 765             


Asn Lys Asn Leu Thr Arg Met Asp Leu Ser Gly Asn Gly Val Gly Phe 
    770                 775                 780                 


Pro Gly Met Met Leu Leu Cys Glu Gly Leu Arg His Pro Gln Cys Arg 
785                 790                 795                 800 


Leu Gln Met Ile Gln Leu Arg Lys Cys Gln Leu Glu Ser Gly Ala Cys 
                805                 810                 815     


Gln Glu Met Ala Ser Val Leu Gly Thr Asn Pro His Leu Val Glu Leu 
            820                 825                 830         


Asp Leu Thr Gly Asn Ala Leu Glu Asp Leu Gly Leu Arg Leu Leu Cys 
        835                 840                 845             


Gln Gly Leu Arg His Pro Val Cys Arg Leu Arg Thr Leu Trp Leu Lys 
    850                 855                 860                 


Ile Cys Arg Leu Thr Ala Ala Ala Cys Asp Glu Leu Ala Ser Thr Leu 
865                 870                 875                 880 


Ser Val Asn Gln Ser Leu Arg Glu Leu Asp Leu Ser Leu Asn Glu Leu 
                885                 890                 895     


Gly Asp Leu Gly Val Leu Leu Leu Cys Glu Gly Leu Arg His Pro Thr 
            900                 905                 910         


Cys Lys Leu Gln Thr Leu Arg Leu Gly Ile Cys Arg Leu Gly Ser Ala 
        915                 920                 925             


Ala Cys Glu Gly Leu Ser Val Val Leu Gln Ala Asn His Asn Leu Arg 
    930                 935                 940                 


Glu Leu Asp Leu Ser Phe Asn Asp Leu Gly Asp Trp Gly Leu Trp Leu 
945                 950                 955                 960 


Leu Ala Glu Gly Leu Gln His Pro Ala Cys Arg Leu Gln Lys Leu Trp 
                965                 970                 975     


Leu Asp Ser Cys Gly Leu Thr Ala Lys Ala Cys Glu Asn Leu Tyr Phe 
            980                 985                 990         


Thr Leu Gly Ile Asn Gln Thr Leu Thr Asp Leu Tyr Leu Thr Asn Asn 
        995                 1000                1005            


Ala Leu Gly Asp Thr Gly Val Arg Leu Leu Cys Lys Arg Leu Ser His 
    1010                1015                1020                


Pro Gly Cys Lys Leu Arg Val Leu Trp Leu Phe Gly Met Asp Leu Asn 
1025                1030                1035                1040


Lys Met Thr His Ser Arg Leu Ala Ala Leu Arg Val Thr Lys Pro Tyr 
                1045                1050                1055    


Leu Asp Ile Gly Cys 
            1060    


<210>  9040
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP12__Homo_sapiens__AAH28069

<400>  9040
augcuacgaa ccgcaggcag ggacggccuc ugucgccugu ccaccuacuu ggaagaacuc       60

gaggcugugg aacugaagaa guucaaguua uaccugggga ccgcgacaga gcugggagaa      120

ggcaagaucc ccuggggaag cauggagaag gccggucccc uggaaauggc ccagcugcuc      180

aucacccacu ucgggccaga ggaggccugg agguuggcuc ucagcaccuu ugagcggaua      240

aacaggaagg accuguggga gagaggacag agagaggacc uggugaggga uaccccaccu      300

gguggcccgu ccucacuugg gaaccaguca acaugccuuc uggaagucuc ucuugucacu      360

ccaagaaaag auccccagga aaccuacagg gacuaugucc gcaggaaauu ccggcucaug      420

gaagaccgca augcgcgccu aggggaaugu gucaaccuca gccaccggua cacccggcuc      480

cugcugguga aggagcacuc aaaccccaug cagguccagc agcagcuucu ggacacaggc      540

cggggacacg cgaggaccgu gggacaccag gcuagcccca ucaagauaga gacccucuuu      600

gagccagacg aggagcgccc cgagccaccg cgcaccgugg ucaugcaagg cgcggcaggg      660

auaggcaagu ccaugcuggc acacaaggug augcuggacu gggcggacgg gaagcucuuc      720

caaggcagau uugauuaucu cuucuacauc aacugcaggg agaugaacca gagugccacg      780

gaaugcagca ugcaagaccu caucuucagc ugcuggccug agcccagcgc gccucuccag      840

gagcucaucc gaguucccga gcgccuccuu uucaucaucg acggcuucga ugagcucaag      900

ccuucuuucc acgauccuca gggacccugg ugccucugcu gggaggagaa acggcccacg      960

gagcugcuuc uuaacagcuu aauucggaag aagcugcucc cugagcuauc uuugcucauc     1020

accacacggc ccacggcuuu ggagaagcuc caccgucugc uggagcaccc caggcaugug     1080

gagauccugg gcuucucuga ggcagaaagg aaggaauacu ucuacaagua uuuccacaau     1140

gcagagcagg cgggccaagu cuucaauuac gugagggaca acgagccucu cuucaccaug     1200

ugcuucgucc cccuggugug cuggguggug uguaccugcc uccagcagca gcuggagggu     1260

ggggggcugu ugagacagac guccaggacc accacugcag uguacaugcu cuaccugcug     1320

agucugaugc aacccaagcc gggggccccg cgccuccagc ccccacccaa ccagagaggg     1380

uugugcuccu uggcggcaga ugggcucugg aaucagaaaa uccuauuuga ggagcaggac     1440

cuccggaagc acggccuaga cggggaagac gucucugccu uccucaacau gaacaucuuc     1500

cagaaggaca ucaacuguga gagguacuac agcuucaucc acuugaguuu ccaggaauuc     1560

uuugcagcua uguacuauau ccuggacgag ggggagggcg gggcaggccc agaccaggac     1620

gugaccaggc uguugaccga guacgcguuu ucugaaagga gcuuccuggc acucaccagc     1680

cgcuuccugu uuggacuccu gaacgaggag accaggagcc accuggagaa gagucucugc     1740

uggaaggucu cgccgcacau caagauggac cuguugcagu ggauccaaag caaagcucag     1800

agcgacggcu ccacccugca gcagggcucc uuggaguucu ucagcugcuu guacgagauc     1860

caggaggagg aguuuaucca gcaggcccug agccacuucc aggugaucgu ggucagcaac     1920

auugccucca agauggagca cauggucucc ucguucuguc ugaagcgcug caggagcgcc     1980

caggugcugc acuuguaugg cgccaccuac agcgcggacg gggaagaccg cgcgaggugc     2040

uccgcaggag cgcacacgcu guuggugcag cuaccagaga ggaccguucu gcuggacgcc     2100

uacagugaac aucuggcagc ggcccugugc accaauccaa accugauaga gcugucucug     2160

uaccgaaaug cccugggcag ccggggggug aagcugcucu gucaaggacu cagacacccc     2220

aacugcaaac uucagaaccu gaggcugaag aggugccgca ucuccagcuc agccugcgag     2280

gaccucucug cagcucucau agccaauaag aauuugacaa ggauggaucu caguggcaac     2340

ggcguuggau ucccaggcau gaugcugcuu ugcgagggcc ugcggcaucc ccagugcagg     2400

cugcagauga uucaguugag gaagugucag cuggaguccg gggcuuguca ggagauggcu     2460

ucugugcucg gcaccaaccc acaucugguu gaguuggacc ugacaggaaa ugcacuggag     2520

gauuugggcc ugagguuacu augccaggga cugaggcacc cagucugcag acuacggacu     2580

uuguggcuga agaucugccg ccucacugcu gcugccugug acgagcuggc cucaacucuc     2640

agugugaacc agagccugag agagcuggac cugagccuga augagcuggg ggaccucggg     2700

gugcugcugc ugugugaggg ccucaggcau cccacgugca agcuccagac ccugcgguug     2760

ggcaucugcc ggcugggcuc ugccgccugu gagggucuuu cuguggugcu ccaggccaac     2820

cacaaccucc gggagcugga cuugaguuuc aacgaccugg gagacugggg ccugugguug     2880

cuggcugagg ggcugcaaca ucccgccugc agacuccaga aacuguggcu ggauagcugu     2940

ggccucacag ccaaggcuug ugagaaucuu uacuucaccc uggggaucaa ccagaccuug     3000

accgaccuuu accugaccaa caacgcccua ggggacacag guguccgacu gcuuugcaag     3060

cggcugagcc auccuggcug caaacuccga guccucuggu uauuugggau ggaccugaau     3120

aaaaugaccc acaguagguu ggcagcgcuu cgaguaacaa aaccuuauuu ggacauuggc     3180

ugcuga                                                                3186


<210>  9041
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP12__Homo_sapiens__AAH28069

<400>  9041
augcugcgca ccgccggccg ggacgggcuc ugccgccuga gcaccuaccu ggaggagcuc       60

gaggccgugg agcugaagaa guucaagcug uaccucggca cggcgaccga gcugggggag      120

ggcaagaucc ccuggggguc cauggagaag gccggcccgc uggagauggc ccagcuccug      180

aucacccacu ucggccccga ggaggccugg cggcuggccc ucagcaccuu cgagcgcauc      240

aaccggaagg accuguggga gcgcgggcag cgggaggacc ugguccgcga cacgccgccc      300

ggcgggcccu ccagccucgg caaccagucc acgugccugc uggaggugag ccucgugacg      360

ccccggaagg acccccagga gaccuaccgc gacuacgucc ggcgcaaguu ccggcugaug      420

gaggaccgca acgcgcggcu gggggagugc gugaaccucu cccaccgcua cacccggcug      480

cugcucguga aggagcacag caaccccaug cagguccagc agcagcugcu ggacaccggc      540

cgcggccacg cccggaccgu ggggcaccag gccuccccga ucaagaucga gacccucuuc      600

gagcccgacg aggagcgccc cgagcccccg cggaccgugg ucaugcaggg cgccgcgggg      660

aucggcaaga gcaugcuggc ccacaaggug augcuggacu gggccgacgg caagcuguuc      720

caggggcgcu ucgacuaccu guucuacauc aacugccgcg agaugaacca guccgccacc      780

gagugcagca ugcaggaccu gaucuucucc ugcuggcccg agcccagcgc gccccuccag      840

gagcugaucc gggugccgga gcgccuccuc uucaucaucg acggcuucga cgagcugaag      900

cccuccuucc acgaccccca ggggcccugg ugccugugcu gggaggagaa gcggccgacc      960

gagcuccugc ugaacagccu cauccgcaag aagcugcugc ccgagcucuc ccugcugauc     1020

accacgcggc ccaccgcccu cgagaagcug caccgccugc uggagcaccc ccggcacguc     1080

gagauccucg gcuucagcga ggccgagcgc aaggaguacu ucuacaagua cuuccacaac     1140

gccgagcagg ccggccaggu guucaacuac gugcgggaca acgagccgcu guucaccaug     1200

ugcuucgucc cccuggugug cugggugguc ugcacgugcc uccagcagca gcuggagggc     1260

ggcgggcugc uccgccagac cucccggacc accaccgccg uguacaugcu guaccugcuc     1320

agccugaugc agcccaagcc cggggcgccg cgccugcagc cgccgcccaa ccagcggggg     1380

cucugcagcc uggccgccga cggccugugg aaccagaaga uccucuucga ggagcaggac     1440

cugcgcaagc acgggcugga cggcgaggac guguccgccu uccucaacau gaacaucuuc     1500

cagaaggaca ucaacugcga gcgguacuac agcuucaucc accuguccuu ccaggaguuc     1560

uucgccgcga uguacuacau ccuggacgag ggcgagggcg gggccgggcc cgaccaggac     1620

gucacgcgcc uccugaccga guacgccuuc agcgagcggu ccuuccuggc ccucaccagc     1680

cgcuuccugu ucggccugcu caacgaggag acccgguccc accuggagaa gucccugugc     1740

uggaagguga gcccccacau caagauggac cuccugcagu ggauccagag caaggcccag     1800

uccgacggga gcacgcugca gcagggcucc cucgaguucu ucagcugccu guacgagauc     1860

caggaggagg aguucaucca gcaggcgcug ucccacuucc aggugaucgu cgugagcaac     1920

aucgccucca agauggagca cauggucagc uccuucugcc ucaagcgcug ccgcagcgcc     1980

caggugcugc accuguacgg cgccaccuac agcgcggacg gggaggaccg ggcccgcugc     2040

uccgccggcg cccacacccu ccuggugcag cugcccgagc ggaccguccu ccuggacgcc     2100

uacagcgagc accuggcggc cgcccucugc acgaacccca accugaucga gcugucccuc     2160

uaccgcaacg cccuggggag ccggggcgug aagcugcucu gccagggccu gcgccacccc     2220

aacugcaagc ugcagaaccu ccggcugaag cgcugccgga ucuccagcuc cgccugcgag     2280

gaccugagcg cggcccucau cgccaacaag aaccugaccc gcauggaccu guccgggaac     2340

ggcguggggu uccccggcau gaugcuccug ugcgaggggc ugcggcaccc ccagugccgc     2400

cuccagauga uccagcugcg gaagugccag cuggagagcg gcgccugcca ggagauggcc     2460

uccguccucg gcaccaaccc gcaccuggug gagcuggacc ucaccgggaa cgcgcuggag     2520

gaccugggcc uccgccugcu gugccagggg cuccggcacc ccgugugccg ccugcggacg     2580

cuguggcuca agaucugccg ccugaccgcc gccgccugcg acgagcuggc gagcacccuc     2640

uccgucaacc agagccugcg ggagcuggac cucucccuga acgagcuggg cgaccucggg     2700

gugcugcugc ucugcgaggg ccugcgccac ccgaccugca agcugcagac ccuccggcug     2760

ggcaucugcc gccuggggag cgccgccugc gagggccugu ccgugguccu ccaggccaac     2820

cacaaccugc gcgagcugga ccucagcuuc aacgaccugg gggacugggg ccuguggcuc     2880

cuggccgagg ggcugcagca ccccgcgugc cggcuccaga agcuguggcu ggacagcugc     2940

ggccucacgg ccaaggccug cgagaaccug uacuucaccc ugggcaucaa ccagacccuc     3000

accgaccugu accugacgaa caacgcccuc ggggacaccg gcgugcgccu gcugugcaag     3060

cggcucuccc accccgggug caagcugcgc gugcuguggc uguucggcau ggaccucaac     3120

aagaugaccc acagccggcu ggccgcgcuc cgcgucacca agcccuaccu ggacaucggg     3180

ugcuga                                                                3186


<210>  9042
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP12__Homo_sapiens__AAH28069

<400>  9042
augcuccgca ccgccggccg cgacggccuc ugccgccucu ccaccuaccu cgaggagcuc       60

gaggccgucg agcucaagaa guucaagcuc uaccucggca ccgccaccga gcucggcgag      120

ggcaagaucc ccuggggcuc cauggagaag gccggccccc ucgagauggc ccagcuccuc      180

aucacccacu ucggccccga ggaggccugg cgccucgccc ucuccaccuu cgagcgcauc      240

aaccgcaagg accucuggga gcgcggccag cgcgaggacc ucguccgcga cacccccccc      300

ggcggccccu ccucccucgg caaccagucc accugccucc ucgaggucuc ccucgucacc      360

ccccgcaagg acccccagga gaccuaccgc gacuacgucc gccgcaaguu ccgccucaug      420

gaggaccgca acgcccgccu cggcgagugc gucaaccucu cccaccgcua cacccgccuc      480

cuccucguca aggagcacuc caaccccaug cagguccagc agcagcuccu cgacaccggc      540

cgcggccacg cccgcaccgu cggccaccag gccuccccca ucaagaucga gacccucuuc      600

gagcccgacg aggagcgccc cgagcccccc cgcaccgucg ucaugcaggg cgccgccggc      660

aucggcaagu ccaugcucgc ccacaagguc augcucgacu gggccgacgg caagcucuuc      720

cagggccgcu ucgacuaccu cuucuacauc aacugccgcg agaugaacca guccgccacc      780

gagugcucca ugcaggaccu caucuucucc ugcuggcccg agcccuccgc cccccuccag      840

gagcucaucc gcguccccga gcgccuccuc uucaucaucg acggcuucga cgagcucaag      900

cccuccuucc acgaccccca gggccccugg ugccucugcu gggaggagaa gcgccccacc      960

gagcuccucc ucaacucccu cauccgcaag aagcuccucc ccgagcucuc ccuccucauc     1020

accacccgcc ccaccgcccu cgagaagcuc caccgccucc ucgagcaccc ccgccacguc     1080

gagauccucg gcuucuccga ggccgagcgc aaggaguacu ucuacaagua cuuccacaac     1140

gccgagcagg ccggccaggu cuucaacuac guccgcgaca acgagccccu cuucaccaug     1200

ugcuucgucc cccucgucug cugggucguc ugcaccugcc uccagcagca gcucgagggc     1260

ggcggccucc uccgccagac cucccgcacc accaccgccg ucuacaugcu cuaccuccuc     1320

ucccucaugc agcccaagcc cggcgccccc cgccuccagc ccccccccaa ccagcgcggc     1380

cucugcuccc ucgccgccga cggccucugg aaccagaaga uccucuucga ggagcaggac     1440

cuccgcaagc acggccucga cggcgaggac gucuccgccu uccucaacau gaacaucuuc     1500

cagaaggaca ucaacugcga gcgcuacuac uccuucaucc accucuccuu ccaggaguuc     1560

uucgccgcca uguacuacau ccucgacgag ggcgagggcg gcgccggccc cgaccaggac     1620

gucacccgcc uccucaccga guacgccuuc uccgagcgcu ccuuccucgc ccucaccucc     1680

cgcuuccucu ucggccuccu caacgaggag acccgcuccc accucgagaa gucccucugc     1740

uggaaggucu ccccccacau caagauggac cuccuccagu ggauccaguc caaggcccag     1800

uccgacggcu ccacccucca gcagggcucc cucgaguucu ucuccugccu cuacgagauc     1860

caggaggagg aguucaucca gcaggcccuc ucccacuucc aggucaucgu cgucuccaac     1920

aucgccucca agauggagca cauggucucc uccuucugcc ucaagcgcug ccgcuccgcc     1980

cagguccucc accucuacgg cgccaccuac uccgccgacg gcgaggaccg cgcccgcugc     2040

uccgccggcg cccacacccu ccucguccag cuccccgagc gcaccguccu ccucgacgcc     2100

uacuccgagc accucgccgc cgcccucugc accaacccca accucaucga gcucucccuc     2160

uaccgcaacg cccucggcuc ccgcggcguc aagcuccucu gccagggccu ccgccacccc     2220

aacugcaagc uccagaaccu ccgccucaag cgcugccgca ucuccuccuc cgccugcgag     2280

gaccucuccg ccgcccucau cgccaacaag aaccucaccc gcauggaccu cuccggcaac     2340

ggcgucggcu uccccggcau gaugcuccuc ugcgagggcc uccgccaccc ccagugccgc     2400

cuccagauga uccagcuccg caagugccag cucgaguccg gcgccugcca ggagauggcc     2460

uccguccucg gcaccaaccc ccaccucguc gagcucgacc ucaccggcaa cgcccucgag     2520

gaccucggcc uccgccuccu cugccagggc cuccgccacc ccgucugccg ccuccgcacc     2580

cucuggcuca agaucugccg ccucaccgcc gccgccugcg acgagcucgc cuccacccuc     2640

uccgucaacc agucccuccg cgagcucgac cucucccuca acgagcucgg cgaccucggc     2700

guccuccucc ucugcgaggg ccuccgccac cccaccugca agcuccagac ccuccgccuc     2760

ggcaucugcc gccucggcuc cgccgccugc gagggccucu ccgucguccu ccaggccaac     2820

cacaaccucc gcgagcucga ccucuccuuc aacgaccucg gcgacugggg ccucuggcuc     2880

cucgccgagg gccuccagca ccccgccugc cgccuccaga agcucuggcu cgacuccugc     2940

ggccucaccg ccaaggccug cgagaaccuc uacuucaccc ucggcaucaa ccagacccuc     3000

accgaccucu accucaccaa caacgcccuc ggcgacaccg gcguccgccu ccucugcaag     3060

cgccucuccc accccggcug caagcuccgc guccucuggc ucuucggcau ggaccucaac     3120

aagaugaccc acucccgccu cgccgcccuc cgcgucacca agcccuaccu cgacaucggc     3180

ugcuga                                                                3186


<210>  9043
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP12__Homo_sapiens__AAH28069

<400>  9043
augcugagaa ccgccggcag ggacgggcuc ugccggcuua gcacauaccu ggaggaauug       60

gaggcugugg aauuaaagaa auucaagcug uaucuaggaa cugcaacgga gcucggugaa      120

ggcaaaaucc ccuggggguc cauggagaag gccggaccuc uggagauggc gcagcuucug      180

auuacccacu uuggcccaga agaggcuugg cgcuuggccc ucucuacauu cgaacgaaua      240

aaccguaaag aucuguggga gagaggucaa agggaggacc ugguccggga uacuccgccc      300

gggggaccuu caagucucgg caaucagagc accuguuuac uggaaguuuc ccuugugaca      360

ccacgcaagg acccccagga gaccuacaga gauuauguaa ggcggaaguu ucgcuugaug      420

gaagaccgaa acgcaagacu gggcgagugc gugaaucuau cucauaggua cacucggcuc      480

cugcuuguca aagaacacuc gaacccuaug caagugcaac agcagcuguu ggauacaggg      540

cguggacaug cccgcaccgu uggucaccag gcuucaccaa ucaagauuga gacguuguuc      600

gagcccgacg aagagagacc ugaaccaccg aggacugugg ucaugcaagg cgcagccggg      660

aucggaaaaa gcaugcuggc ucauaaggug auguuagauu gggccgacgg caaacuguuu      720

cagggucggu ucgauuaucu cuuuuacauu aauugucgag agaugaacca gagugcgacc      780

gaaugcucca ugcaggaccu uaucuucucu uguuggcccg agccuagcgc accacugcaa      840

gaguugauac gcguacccga aagacuacug uuuaucauug auggguucga cgagcucaag      900

ccuuccuuuc acgacccaca gggacccugg ugccuguguu gggaagagaa gaggccgaca      960

gaacuucugc ucaauucacu cauccggaaa aagcuguuac cugagcugag ucuacucauu     1020

acuacccgcc ccacagcccu ggagaaacuu cacagauugc uggaacaucc aaggcacguu     1080

gagauccucg gcuucagcga agcugagcgu aaggaguauu uuuacaaaua cuuccauaac     1140

gccgaacagg caggccaagu guucaauuau guccgggaua acgagccucu guuuaccaug     1200

ugcuucgugc cccuugugug uugggucguu ugcacguguc ugcagcagca guuggaaggg     1260

ggaggucucc ugcgacaaac uucuagaaca accacugcug uguacauguu auaucugcua     1320

ucccucaugc agccaaagcc cggcgccccu aggcugcagc caccgcccaa ucagcgcggg     1380

cuuugcucau uggcggccga cggacugugg aaccagaaaa uacucuuuga ggaacaggau     1440

cugcggaagc acggcuuaga cggugaggau guaagcgcau uccugaauau gaacauuuuu     1500

cagaaggaca ucaauugcga gagauacuau aguuucauuc accuuucuuu ucaggaguuc     1560

uuugcugcca uguacuauau cuuggaugaa ggggaaggcg gagcuggccc ugaccaagau     1620

gugacaaggc uccugaccga guacgccuuc uccgaacgca gcuuucuagc acugacgucg     1680

cgauuccucu uugggcugcu uaacgaggag acccggucuc auuuggaaaa aucccugugu     1740

uggaaggucu caccacacau caaaauggac uuacuccagu ggauucagag uaaggcccag     1800

agcgauggau ccacacugca acaggguucu cuugaguucu ucagcugccu guacgaaaua     1860

caggaggaag aguuuaucca acaggcuuug ucacauuucc aggugauugu ugugaguaac     1920

aucgcgucca aaauggagca cauggucagc ucuuuuuguc ucaagcguug cagaucagca     1980

caggugcugc aucuauaugg cgccacuuac agugcugacg gggaagacag ggcccgcugu     2040

agcgcaggag cccacacccu gcucguacaa cugcccgagc ggacaguucu uuuggaugcu     2100

uauuccgaac accuggccgc agcguuaugc acuaauccua accucauaga gcugucucuu     2160

uacagaaaug cucugggcuc gaggggugug aagcuacucu gucaggggcu gcgacaucca     2220

aacugcaaau ugcagaaucu gcgcuuaaag cgguguagaa uuagcuccuc agccugcgag     2280

gaccucagug cagcccugau cgcuaacaaa aaucuuacca ggauggaucu gucuggcaac     2340

ggagucggcu uccccgggau gauguugcuc ugugaaggac ugcgucaccc gcagugccgc     2400

cuacaaauga uccagcugcg gaagugccag cuugagagcg gugccuguca ggaaauggca     2460

uccgugcucg gcacaaaucc ucaucugguc gaguuggacc ugaccgggaa cgcuuuagaa     2520

gaucucggac ugagacuucu gugccaaggc uugaggcacc cagugugucg acuccggacu     2580

cuguggcuaa aaauuugccg ccugacggcc gcggccugug acgagcuugc uucaacacuc     2640

agcguuaauc agucucugag agaguuggau uuaucccuga acgaacucgg ugaccugggg     2700

gugcuucugu ugugcgaggg ccuaaggcac cccaccugua agcugcagac ucuccggcug     2760

ggaaucugcc gacuuggcag ugcagccugu gaaggguuaa gcguaguccu gcaagcuaau     2820

cauaaccuca gagaguugga ucugucuuuu aaugaccucg gagauugggg ccuguggcuu     2880

cuggccgaag guuugcagca cccugcaugc cgccuacaga agcuguggcu cgacuccugu     2940

ggguuaaccg cgaaagccug cgagaaccug uauuucacac uuggaauuaa ccagacccug     3000

acugaucucu acuugacaaa uaacgcucug ggcgacacgg gugugaggcu ccugugcaag     3060

cgucuuucac aucccggcug uaaacuacgg guucuguggu uguuugggau ggacuuaaau     3120

aagaugaccc acaguagacu ggccgcacuc agggugacua aaccauaucu ggauauagga     3180

ugcuga                                                                3186


<210>  9044
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP12__Homo_sapiens__AAH28069

<400>  9044
augcugagaa ccgccggcag agacggccug ugcagacuga gcaccuaccu ggaggagcug       60

gaggccgugg agcugaagaa guucaagcug uaccugggca ccgccaccga gcugggcgag      120

ggcaagaucc ccuggggcag cauggagaag gccggccccc uggagauggc ccagcugcug      180

aucacccacu ucggccccga ggaggccugg agacuggccc ugagcaccuu cgagagaauc      240

aacagaaagg accuguggga gagaggccag agagaggacc uggugagaga cacccccccc      300

ggcggcccca gcagccuggg caaccagagc accugccugc uggaggugag ccuggugacc      360

cccagaaagg acccccagga gaccuacaga gacuacguga gaagaaaguu cagacugaug      420

gaggacagaa acgccagacu gggcgagugc gugaaccuga gccacagaua caccagacug      480

cugcugguga aggagcacag caaccccaug caggugcagc agcagcugcu ggacaccggc      540

agaggccacg ccagaaccgu gggccaccag gccagcccca ucaagaucga gacccuguuc      600

gagcccgacg aggagagacc cgagcccccc agaaccgugg ugaugcaggg cgccgccggc      660

aucggcaaga gcaugcuggc ccacaaggug augcuggacu gggccgacgg caagcuguuc      720

cagggcagau ucgacuaccu guucuacauc aacugcagag agaugaacca gagcgccacc      780

gagugcagca ugcaggaccu gaucuucagc ugcuggcccg agcccagcgc cccccugcag      840

gagcugauca gagugcccga gagacugcug uucaucaucg acggcuucga cgagcugaag      900

cccagcuucc acgaccccca gggccccugg ugccugugcu gggaggagaa gagacccacc      960

gagcugcugc ugaacagccu gaucagaaag aagcugcugc ccgagcugag ccugcugauc     1020

accaccagac ccaccgcccu ggagaagcug cacagacugc uggagcaccc cagacacgug     1080

gagauccugg gcuucagcga ggccgagaga aaggaguacu ucuacaagua cuuccacaac     1140

gccgagcagg ccggccaggu guucaacuac gugagagaca acgagccccu guucaccaug     1200

ugcuucgugc cccuggugug cuggguggug ugcaccugcc ugcagcagca gcuggagggc     1260

ggcggccugc ugagacagac cagcagaacc accaccgccg uguacaugcu guaccugcug     1320

agccugaugc agcccaagcc cggcgccccc agacugcagc ccccccccaa ccagagaggc     1380

cugugcagcc uggccgccga cggccugugg aaccagaaga uccuguucga ggagcaggac     1440

cugagaaagc acggccugga cggcgaggac gugagcgccu uccugaacau gaacaucuuc     1500

cagaaggaca ucaacugcga gagauacuac agcuucaucc accugagcuu ccaggaguuc     1560

uucgccgcca uguacuacau ccuggacgag ggcgagggcg gcgccggccc cgaccaggac     1620

gugaccagac ugcugaccga guacgccuuc agcgagagaa gcuuccuggc ccugaccagc     1680

agauuccugu ucggccugcu gaacgaggag accagaagcc accuggagaa gagccugugc     1740

uggaagguga gcccccacau caagauggac cugcugcagu ggauccagag caaggcccag     1800

agcgacggca gcacccugca gcagggcagc cuggaguucu ucagcugccu guacgagauc     1860

caggaggagg aguucaucca gcaggcccug agccacuucc aggugaucgu ggugagcaac     1920

aucgccagca agauggagca cauggugagc agcuucugcc ugaagagaug cagaagcgcc     1980

caggugcugc accuguacgg cgccaccuac agcgccgacg gcgaggacag agccagaugc     2040

agcgccggcg cccacacccu gcuggugcag cugcccgaga gaaccgugcu gcuggacgcc     2100

uacagcgagc accuggccgc cgcccugugc accaacccca accugaucga gcugagccug     2160

uacagaaacg cccugggcag cagaggcgug aagcugcugu gccagggccu gagacacccc     2220

aacugcaagc ugcagaaccu gagacugaag agaugcagaa ucagcagcag cgccugcgag     2280

gaccugagcg ccgcccugau cgccaacaag aaccugacca gaauggaccu gagcggcaac     2340

ggcgugggcu uccccggcau gaugcugcug ugcgagggcc ugagacaccc ccagugcaga     2400

cugcagauga uccagcugag aaagugccag cuggagagcg gcgccugcca ggagauggcc     2460

agcgugcugg gcaccaaccc ccaccuggug gagcuggacc ugaccggcaa cgcccuggag     2520

gaccugggcc ugagacugcu gugccagggc cugagacacc ccgugugcag acugagaacc     2580

cuguggcuga agaucugcag acugaccgcc gccgccugcg acgagcuggc cagcacccug     2640

agcgugaacc agagccugag agagcuggac cugagccuga acgagcuggg cgaccugggc     2700

gugcugcugc ugugcgaggg ccugagacac cccaccugca agcugcagac ccugagacug     2760

ggcaucugca gacugggcag cgccgccugc gagggccuga gcguggugcu gcaggccaac     2820

cacaaccuga gagagcugga ccugagcuuc aacgaccugg gcgacugggg ccuguggcug     2880

cuggccgagg gccugcagca ccccgccugc agacugcaga agcuguggcu ggacagcugc     2940

ggccugaccg ccaaggccug cgagaaccug uacuucaccc ugggcaucaa ccagacccug     3000

accgaccugu accugaccaa caacgcccug ggcgacaccg gcgugagacu gcugugcaag     3060

agacugagcc accccggcug caagcugaga gugcuguggc uguucggcau ggaccugaac     3120

aagaugaccc acagcagacu ggccgcccug agagugacca agcccuaccu ggacaucggc     3180

ugcuga                                                                3186


<210>  9045
<211>  3186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP12__Homo_sapiens__AAH28069

<400>  9045
augcugagaa ccgccggccg ggacgggcuc ugccgccuga gcacauaccu ugaggaacug       60

gaggcugugg aacucaagaa auucaagcug uaucuuggaa cggccaccga gcugggcgaa      120

gggaaaaucc ccuggggauc cauggagaag gcgggcccuc ucgagauggc ucagcugcug      180

auuacacacu uugggccgga agaggccugg agacucgccc ugucuaccuu cgaacggauc      240

aaccgcaaag aucuuuggga gagaggacaa cgggaggacc ugguccgcga uacacccccu      300

ggcggcccca gcucccucgg gaaucagucu accugucugc uugaaguuag ccuggugaca      360

ccuagaaagg acccccagga gaccuaccgg gauuaugugc gcagaaaguu ucggcucaug      420

gaagaccgca acgcuagacu gggagagugc gucaaucugu cccaucggua cacgcgccuc      480

cugcuuguga aagaacacuc uaacccuaug cagguucaac agcagcugcu cgauaccggc      540

agagggcaug cccggacagu gggacaccag gcuagcccga uuaagaucga gacccuguuc      600

gagcccgacg aagagagacc ugaacccccu cgcacagucg ugaugcaagg cgccgcgggg      660

auuggaaaau ccaugcuugc ccauaagguu augcuggauu gggcugacgg caaacucuuu      720

cagggccggu ucgauuaucu guuuuacauc aauuguagag agaugaacca gagcgccacc      780

gaaugcucua ugcaggaccu gaucuucucc uguuggcccg agccgagcgc uccucuccaa      840

gagcugauuc gcgugcccga acggcuucug uuuaucauug auggguucga cgagcucaag      900

ccuucuuuuc acgaccccca gggacccugg ugccuguguu gggaagagaa gagaccuacg      960

gaacuucugc ucaauucccu gauccgcaaa aagcugcucc cggagcugag ccuucugauu     1020

acaacccggc ccacagcccu cgagaaacug cacagacugc uugaacaucc ucgccacguc     1080

gagauccucg gcuucucuga agcggagcgg aaggaguauu uuuacaaaua cuuccauaac     1140

gccgaacagg cugggcaagu guucaauuau gugagagaua acgagccccu guuuaccaug     1200

ugcuucgucc cucugguuug uuggguggug ugcaccuguc uccagcagca gcuggaagga     1260

ggcgggcuuc ugcgccaaac aucccggacg accacagccg ucuacaugcu cuaucugcug     1320

agccuuaugc agcccaagcc gggagcuccu agacuccagc ccccucccaa ucagcggggc     1380

cugugcuccc uggccgccga cggccucugg aaccagaaaa uucuguuuga ggaacaagau     1440

cuucgcaagc acgggcugga cggagaggau gugucugcuu uccucaauau gaacaucuuu     1500

cagaaggaca ucaauugcga gagauacuau agcuucauuc accuguccuu ucaggaguuc     1560

uuugcggcca uguacuauau ccuggaugaa ggcgaagggg gagcuggccc ugaccaagau     1620

guuacccggc uucucacaga guacgccuuc agcgaaagau cuuuucuggc ccugaccucc     1680

cgcuuccucu uugggcugcu uaacgaggag acgcggagcc aucuggaaaa aucucucugu     1740

uggaagguga gcccccacau uaaaauggac cugcugcagu ggauccaguc caaggcucag     1800

ucugauggca gcacacuuca acagggaucc cucgaguucu ucagcugccu guacgaaauu     1860

caggaggaag aguuuaucca acaggcccug ucucauuucc aggucaucgu gguuuccaac     1920

auugcgagca aaauggagca cauggugucu uccuuuuguc ucaagagaug ccgcagcgcu     1980

cagguccugc aucuuuaugg cgccaccuac uccgccgacg gggaagacag agcucggugu     2040

ucugccggag cucacacccu gcucgugcaa cugccggagc gcacaguccu gcuugaugcc     2100

uauagcgaac accuggcggc cgcucucugc accaauccua accugaucga gcucucccug     2160

uacagaaaug cccuuggcuc ucgcggggug aagcugcucu gucagggacu gcggcauccc     2220

aacugcaaac ugcagaaucu uagacugaag cggugucgca uuagcuccag cgcuugcgag     2280

gaccucucug ccgcgcugau cgccaacaaa aaucucacaa gaauggaucu guccggcaac     2340

gggguuggcu uccccggaau gaugcuucug ugugaaggcc uccggcaccc ucagugccgc     2400

cugcaaauga uucagcugag aaagugccag cuugagagcg gggcuuguca ggaaauggcc     2460

ucugugcugg gaacgaaucc gcaucucguc gagcuggacc ucaccggcaa cgcucuggaa     2520

gaucuugggc ugcggcugcu cugccaagga cugagacacc ccgugugucg ccuucggaca     2580

cuguggcuca aaaucugcag acugaccgcc gccgcuugug acgagcucgc guccacacug     2640

agcguuaauc agucucuucg cgagcuggau cugagccuca acgaacuggg cgaccuuggg     2700

gugcugcucc ugugcgaggg ccuccggcac ccuaccugua agcugcagac gcuuagacug     2760

ggaaucugcc gccugggcuc cgccgcuugu gaagggcuca gcgucgugcu gcaagccaau     2820

cauaaccuuc gggagcugga ucucucuuuu aaugaccugg gagauugggg ccucuggcug     2880

cuugccgaag ggcugcagca ccccgcuugc agacugcaga agcucuggcu ggacuccugu     2940

ggacuuaccg ccaaagcgug cgagaaccug uauuucacac ucggcauuaa ccagacccug     3000

acagaucugu accucaccaa uaacgcucuu ggggacacgg gcgugcgccu gcugugcaag     3060

cggcucagcc auccuggaug uaaacugaga guucuuuggc uguuuggcau ggaccucaau     3120

aagaugacac acucccggcu ggccgcccug cgcgucacca aacccuaucu cgauaucggg     3180

ugcuga                                                                3186


<210>  9046
<211>  1043
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP13__Homo_sapiens__Q86W25

<400>  9046

Met Asn Phe Ser Val Ile Thr Cys Pro Asn Gly Gly Thr Asn Gln Gly 
1               5                   10                  15      


Leu Leu Pro Tyr Leu Met Ala Leu Asp Gln Tyr Gln Leu Glu Glu Phe 
            20                  25                  30          


Lys Leu Cys Leu Glu Pro Gln Gln Leu Met Asp Phe Trp Ser Ala Pro 
        35                  40                  45              


Gln Gly His Phe Pro Arg Ile Pro Trp Ala Asn Leu Arg Ala Ala Asp 
    50                  55                  60                  


Pro Leu Asn Leu Ser Phe Leu Leu Asp Glu His Phe Pro Lys Gly Gln 
65                  70                  75                  80  


Ala Trp Lys Val Val Leu Gly Ile Phe Gln Thr Met Asn Leu Thr Ser 
                85                  90                  95      


Leu Cys Glu Lys Val Arg Ala Glu Met Lys Glu Asn Val Gln Thr Gln 
            100                 105                 110         


Glu Leu Gln Asp Pro Thr Gln Glu Asp Leu Glu Met Leu Glu Ala Ala 
        115                 120                 125             


Ala Gly Asn Met Gln Thr Gln Gly Cys Gln Asp Pro Asn Gln Glu Glu 
    130                 135                 140                 


Leu Asp Glu Leu Glu Glu Glu Thr Gly Asn Val Gln Ala Gln Gly Cys 
145                 150                 155                 160 


Gln Asp Pro Asn Gln Glu Glu Pro Glu Met Leu Glu Glu Ala Asp His 
                165                 170                 175     


Arg Arg Lys Tyr Arg Glu Asn Met Lys Ala Glu Leu Leu Glu Thr Trp 
            180                 185                 190         


Asp Asn Ile Ser Trp Pro Lys Asp His Val Tyr Ile Arg Asn Thr Ser 
        195                 200                 205             


Lys Asp Glu His Glu Glu Leu Gln Arg Leu Leu Asp Pro Asn Arg Thr 
    210                 215                 220                 


Arg Ala Gln Ala Gln Thr Ile Val Leu Val Gly Arg Ala Gly Val Gly 
225                 230                 235                 240 


Lys Thr Thr Leu Ala Met Gln Ala Met Leu His Trp Ala Asn Gly Val 
                245                 250                 255     


Leu Phe Gln Gln Arg Phe Ser Tyr Val Phe Tyr Leu Ser Cys His Lys 
            260                 265                 270         


Ile Arg Tyr Met Lys Glu Thr Thr Phe Ala Glu Leu Ile Ser Leu Asp 
        275                 280                 285             


Trp Pro Asp Phe Asp Ala Pro Ile Glu Glu Phe Met Ser Gln Pro Glu 
    290                 295                 300                 


Lys Leu Leu Phe Ile Ile Asp Gly Phe Glu Glu Ile Ile Ile Ser Glu 
305                 310                 315                 320 


Ser Arg Ser Glu Ser Leu Asp Asp Gly Ser Pro Cys Thr Asp Trp Tyr 
                325                 330                 335     


Gln Glu Leu Pro Val Thr Lys Ile Leu His Ser Leu Leu Lys Lys Glu 
            340                 345                 350         


Leu Val Pro Leu Ala Thr Leu Leu Ile Thr Ile Lys Thr Trp Phe Val 
        355                 360                 365             


Arg Asp Leu Lys Ala Ser Leu Val Asn Pro Cys Phe Val Gln Ile Thr 
    370                 375                 380                 


Gly Phe Thr Gly Asp Asp Leu Arg Val Tyr Phe Met Arg His Phe Asp 
385                 390                 395                 400 


Asp Ser Ser Glu Val Glu Lys Ile Leu Gln Gln Leu Arg Lys Asn Glu 
                405                 410                 415     


Thr Leu Phe His Ser Cys Ser Ala Pro Met Val Cys Trp Thr Val Cys 
            420                 425                 430         


Ser Cys Leu Lys Gln Pro Lys Val Arg Tyr Tyr Asp Leu Gln Ser Ile 
        435                 440                 445             


Thr Gln Thr Thr Thr Ser Leu Tyr Ala Tyr Phe Phe Ser Asn Leu Phe 
    450                 455                 460                 


Ser Thr Ala Glu Val Asp Leu Ala Asp Asp Ser Trp Pro Gly Gln Trp 
465                 470                 475                 480 


Arg Ala Leu Cys Ser Leu Ala Ile Glu Gly Leu Trp Ser Met Asn Phe 
                485                 490                 495     


Thr Phe Asn Lys Glu Asp Thr Glu Ile Glu Gly Leu Glu Val Pro Phe 
            500                 505                 510         


Ile Asp Ser Leu Tyr Glu Phe Asn Ile Leu Gln Lys Ile Asn Asp Cys 
        515                 520                 525             


Gly Gly Cys Thr Thr Phe Thr His Leu Ser Phe Gln Glu Phe Phe Ala 
    530                 535                 540                 


Ala Met Ser Phe Val Leu Glu Glu Pro Arg Glu Phe Pro Pro His Ser 
545                 550                 555                 560 


Thr Lys Pro Gln Glu Met Lys Met Leu Leu Gln His Val Leu Leu Asp 
                565                 570                 575     


Lys Glu Ala Tyr Trp Thr Pro Val Val Leu Phe Phe Phe Gly Leu Leu 
            580                 585                 590         


Asn Lys Asn Ile Ala Arg Glu Leu Glu Asp Thr Leu His Cys Lys Ile 
        595                 600                 605             


Ser Pro Arg Val Met Glu Glu Leu Leu Lys Trp Gly Glu Glu Leu Gly 
    610                 615                 620                 


Lys Ala Glu Ser Ala Ser Leu Gln Phe His Ile Leu Arg Leu Phe His 
625                 630                 635                 640 


Cys Leu His Glu Ser Gln Glu Glu Asp Phe Thr Lys Lys Met Leu Gly 
                645                 650                 655     


Arg Ile Phe Glu Val Asp Leu Asn Ile Leu Glu Asp Glu Glu Leu Gln 
            660                 665                 670         


Ala Ser Ser Phe Cys Leu Lys His Cys Lys Arg Leu Asn Lys Leu Arg 
        675                 680                 685             


Leu Ser Val Ser Ser His Ile Leu Glu Arg Asp Leu Glu Ile Leu Glu 
    690                 695                 700                 


Thr Ser Lys Phe Asp Ser Arg Met His Ala Trp Asn Ser Ile Cys Ser 
705                 710                 715                 720 


Thr Leu Val Thr Asn Glu Asn Leu His Glu Leu Asp Leu Ser Asn Ser 
                725                 730                 735     


Lys Leu His Ala Ser Ser Val Lys Gly Leu Cys Leu Ala Leu Lys Asn 
            740                 745                 750         


Pro Arg Cys Lys Val Gln Lys Leu Thr Cys Lys Ser Val Thr Pro Glu 
        755                 760                 765             


Trp Val Leu Gln Asp Leu Ile Ile Ala Leu Gln Gly Asn Ser Lys Leu 
    770                 775                 780                 


Thr His Leu Asn Phe Ser Ser Asn Lys Leu Gly Met Thr Val Pro Leu 
785                 790                 795                 800 


Ile Leu Lys Ala Leu Arg His Ser Ala Cys Asn Leu Lys Tyr Leu Cys 
                805                 810                 815     


Leu Glu Lys Cys Asn Leu Ser Ala Ala Ser Cys Gln Asp Leu Ala Leu 
            820                 825                 830         


Phe Leu Thr Ser Ile Gln His Val Thr Arg Leu Cys Leu Gly Phe Asn 
        835                 840                 845             


Arg Leu Gln Asp Asp Gly Ile Lys Leu Leu Cys Ala Ala Leu Thr His 
    850                 855                 860                 


Pro Lys Cys Ala Leu Glu Arg Leu Glu Leu Trp Phe Cys Gln Leu Ala 
865                 870                 875                 880 


Ala Pro Ala Cys Lys His Leu Ser Asp Ala Leu Leu Gln Asn Arg Ser 
                885                 890                 895     


Leu Thr His Leu Asn Leu Ser Lys Asn Ser Leu Arg Asp Glu Gly Val 
            900                 905                 910         


Lys Phe Leu Cys Glu Ala Leu Gly Arg Pro Asp Gly Asn Leu Gln Ser 
        915                 920                 925             


Leu Asn Leu Ser Gly Cys Ser Phe Thr Arg Glu Gly Cys Gly Glu Leu 
    930                 935                 940                 


Ala Asn Ala Leu Ser His Asn His Asn Val Lys Ile Leu Asp Leu Gly 
945                 950                 955                 960 


Glu Asn Asp Leu Gln Asp Asp Gly Val Lys Leu Leu Cys Glu Ala Leu 
                965                 970                 975     


Lys Pro His Arg Ala Leu His Thr Leu Gly Leu Ala Lys Cys Asn Leu 
            980                 985                 990         


Thr Thr Ala Cys Cys Gln His Leu Phe Ser Val Leu Ser Ser Ser Lys 
        995                 1000                1005            


Ser Leu Val Asn Leu Asn Leu Leu Gly Asn Glu Leu Asp Thr Asp Gly 
    1010                1015                1020                


Val Lys Met Leu Cys Lys Ala Leu Lys Lys Ser Thr Cys Arg Leu Gln 
1025                1030                1035                1040


Lys Leu Gly 
            


<210>  9047
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP13__Homo_sapiens__CCDS33119.1

<400>  9047
augaacuuuu cuguaaucac cugccccaac ggugguacca accaagggcu ucugccuuac       60

cugauggccc uggaucagua ucagcuggag gaauucaagc uuugcuugga accccagcag      120

cugauggacu ucuggucggc cccccagggg cacuucccgc guauccccug ggcaaacuug      180

agagcugccg acccuuugaa ucuguccuuu cuuuuggaug aacacuuccc aaaaggucag      240

gcauggaaag ugguccucgg caucuuccag acaaugaauc ugaccucacu gugugagaaa      300

guuagagccg agaugaaaga gaaugugcag acccaagagc ugcaagaucc aacccaggaa      360

gaucuagaga ugcuagaagc agcagcaggg aauaugcaga cccagggaug ccaagaucca      420

aaccaagaag aacuagacga gcuagaagaa gaaacaggga auguacaggc ccagggaugc      480

caagauccaa accaagaaga accagagaug cuagaggaag cagaccacag aagaaaauac      540

agagagaaca ugaaggcuga acuacuggag acaugggaca acaucaguug gccuaaagac      600

cacguauaua uccguaauac aucaaaggac gaacaugagg aacugcagcg ccuacuggau      660

ccuaauagga cuagagccca ggcccagacg auagucuugg uggggagggc agggguuggg      720

aagaccaccu uggcaaugca ggcuaugcug cacugggcaa auggaguucu cuuucagcaa      780

agguucuccu auguuuucua ucucagcugc cauaaaauaa gguacaugaa ggaaacuacc      840

uuugcugaau ugauuucuuu ggauuggccc gauuuugaug cccccauuga agaguucaug      900

ucucaaccag agaagcuccu guuuauuauu gauggcuuug aggaaauaau cauaucugag      960

ucacgcucug agagcuugga ugauggcucg ccauguacag acugguacca ggagcuccca     1020

gugaccaaaa uccuacacag cuuguugaag aaagaauugg uuccccuggc uaccuuacug     1080

aucacgauca agaccugguu ugugagagau cuuaaggccu cauuagugaa uccaugcuuu     1140

guacaaauua caggguucac aggggacgac cuacggguau auuucaugag acacuuugau     1200

gacucaagug aaguugagaa aauccugcag cagcuaagaa aaaacgaaac ucucuuucau     1260

uccugcagug cccccauggu guguuggacc guauguuccu gucugaagca gccgaaggug     1320

agguauuacg aucuccaguc aaucacucag acuaccacca gucuguaugc cuauuuuuuc     1380

uccaacuugu ucuccacagc agagguagau uuggcagaug acagcuggcc aggacaaugg     1440

agggcccucu gcagucuggc cauagaaggg cuguggucua ugaacuucac guuuaacaaa     1500

gaagacacug agaucgaggg ccuggaagug ccuuucauug auucucucua cgaguucaau     1560

auucuucaaa agaucaauga cugugggggu ugcacuacuu ucacccaccu aaguuuccag     1620

gaguuuuuug cagccauguc cuuugugcua gaggaaccua gagaauuccc uccccauucc     1680

acaaagccac aagagaugaa gauguuacug caacacgucu ugcuugacaa agaagccuac     1740

uggacuccag ugguucuguu cuucuuuggu cuuuuaaaua aaaacauagc aagagaacug     1800

gaagauacuu ugcauuguaa aauaucuccc aggguaaugg aggaauuauu aaagugggga     1860

gaagaguuag guaaggcuga aagugccucu cuccaauuuc acauucuacg acuuuuucac     1920

ugccuacacg agucccagga ggaagacuuc acaaagaaga uguugggucg uaucuuugaa     1980

guugaccuua auauuuugga ggacgaagaa cuccaagcuu cuucauuuug ccuaaagcac     2040

uguaaaaggu uaaauaagcu aaggcuuucu guuagcaguc acauccuuga aagggacuug     2100

gaaauucugg agacaagcaa guuugauucc aggaugcacg cauggaacag cauuugcucu     2160

acguugguca caaaugagaa ucugcaugag cuagaccuga guaacagcaa acuucaugcu     2220

uccucuguga agggucucug ucuugcacug aaaaauccaa gaugcaaagu ccagaaacug     2280

acgugcaaau cgguaacucc ugaguggguu cugcaggacc ucauuauugc ccuucagggu     2340

aacagcaagc ugacccaucu gaacuucagc ucuaacaagc ugggaaugac ugucccccug     2400

auucuuaaag cuuugagaca cucagcuugc aaccucaagu aucugugccu ggagaaaugc     2460

aacuugucgg cagccagcug ucaggaccua gccuuguuuc ucaccagcau ccaacacgua     2520

acucgauugu gccugggauu uaaucggcuc caagaugaug gcauaaagcu auugugugcg     2580

gcccugacuc accccaagug ugccuuagag agacuggagc ucugguuuug ccagcuggca     2640

gcacccgcuu gcaagcacuu gucagaugcu cuccugcaga acaggagccu gacacaccug     2700

aaucugagca agaacagccu gagagacgag ggagucaagu uccuguguga ggccuugggu     2760

cgcccagaug guaaccugca gagccugaau uugucagguu guucuuucac aagagagggc     2820

uguggagagc uggcuaaugc ccucagccau aaucauaaug ugaaaaucuu ggauuuggga     2880

gaaaaugauc uucaggauga uggagugaag cuacugugug aggcucugaa accacaucgu     2940

gcauugcaca cacuuggguu ggcgaaaugc aaucugacaa cugcuugcug ccagcaucuc     3000

uucucuguuc ucagcagcag uaagagccug gucaaucuga accuucuagg caaugaauug     3060

gauacugaug gugucaagau gcuauguaag gcuuugaaaa agucgacaug caggcugcag     3120

aaacucgggu aa                                                         3132


<210>  9048
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP13__Homo_sapiens__CCDS33119.1

<400>  9048
augaacuuca gcgugaucac gugccccaac ggcgggacca accagggccu gcucccguac       60

cugauggccc uggaccagua ccagcucgag gaguucaagc ugugccugga gccccagcag      120

cucauggacu ucuggagcgc gccccagggg cacuuccccc gcaucccgug ggccaaccug      180

cgggccgccg acccccugaa ccucagcuuc cugcuggacg agcacuuccc caagggccag      240

gccuggaagg ucgugcucgg gaucuuccag accaugaacc ugaccucccu gugcgagaag      300

gugcgcgccg agaugaagga gaacguccag acccaggagc uccaggaccc cacccaggag      360

gaccuggaga ugcuggaggc ggccgccggc aacaugcaga cgcagggcug ccaggacccg      420

aaccaggagg agcucgacga gcuggaggag gagaccggga acgugcaggc ccagggcugc      480

caggacccca accaggagga gcccgagaug cuggaggagg cggaccaccg gcgcaaguac      540

cgggagaaca ugaaggccga gcuccuggag accugggaca acaucagcug gcccaaggac      600

cacguguaca uccgcaacac cuccaaggac gagcacgagg agcugcagcg gcuccuggac      660

ccgaaccgca cgcgggccca ggcccagacc aucguccugg uggggcgcgc cggcgugggg      720

aagaccaccc ucgcgaugca ggccaugcug cacugggcca acggcguccu guuccagcag      780

cgguucagcu acguguucua ccucuccugc cacaagaucc gcuacaugaa ggagacgacc      840

uucgccgagc ugaucagccu ggacuggccc gacuucgacg cccccaucga ggaguucaug      900

ucccagcccg agaagcuccu guucaucauc gacggcuucg aggagaucau caucagcgag      960

ucccggagcg agucccugga cgacgggagc ccgugcaccg acugguacca ggagcucccc     1020

gugaccaaga uccugcacuc ccugcucaag aaggagcugg ucccccuggc gacgcuccug     1080

aucaccauca agaccugguu cgugcgcgac cugaaggcca gccucgugaa ccccugcuuc     1140

guccagauca ccggcuucac gggggacgac cugcgggugu acuucaugcg ccacuucgac     1200

gacuccagcg agguggagaa gauccugcag cagcuccgga agaacgagac ccuguuccac     1260

uccugcagcg ccccgauggu cugcuggacc gugugcagcu gccugaagca gcccaaggug     1320

cgcuacuacg accugcaguc caucacccag acgaccacca gccucuacgc cuacuucuuc     1380

uccaaccugu ucagcaccgc cgaggucgac cuggcggacg acuccuggcc cggccagugg     1440

cgggcccucu gcagccuggc caucgagggc cuguggucca ugaacuucac guucaacaag     1500

gaggacaccg agaucgaggg gcucgaggug cccuucaucg acagccugua cgaguucaac     1560

auccugcaga agaucaacga cugcggcggg ugcaccaccu ucacgcaccu cuccuuccag     1620

gaguucuucg ccgccaugag cuucgugcug gaggagccgc gcgaguuccc gccccacucc     1680

accaagcccc aggagaugaa gaugcugcuc cagcacgucc ugcuggacaa ggaggcguac     1740

uggacccccg ugguccucuu cuucuucggc cugcugaaca agaacaucgc ccgggagcuc     1800

gaggacaccc ugcacugcaa gaucagcccc cgcgugaugg aggagcugcu caaguggggc     1860

gaggagcugg ggaaggccga guccgccagc cugcaguucc acauccuccg ccuguuccac     1920

ugccugcacg agucccagga ggaggacuuc acgaagaaga ugcucggccg gaucuucgag     1980

guggaccuga acauccugga ggacgaggag cuccaggcga gcuccuucug ccugaagcac     2040

ugcaagcgcc ugaacaagcu ccggcugagc gucuccagcc acauccugga gcgcgaccuc     2100

gagauccugg agaccagcaa guucgacucc cggaugcacg ccuggaacag caucugcucc     2160

acccugguga ccaacgagaa ccuccacgag cuggaccuga gcaacuccaa gcuccacgcc     2220

agcuccguga aggggcugug ccuggcccuc aagaaccccc gcugcaaggu ccagaagcug     2280

accugcaaga gcgugacgcc ggagugggug cugcaggacc ucaucaucgc ccugcagggc     2340

aacuccaagc ugacccaccu caacuucagc uccaacaagc uggggaugac cgucccccug     2400

auccucaagg cgcugcggca cagcgccugc aaccugaagu accucugccu ggagaagugc     2460

aaccuguccg ccgccagcug ccaggaccuc gcccuguucc ugaccuccau ccagcacgug     2520

acgcgccucu gccugggcuu caaccggcug caggacgacg ggaucaagcu ccugugcgcg     2580

gcccugaccc accccaagug cgcccucgag cgccuggagc ugugguucug ccagcucgcc     2640

gcccccgcgu gcaagcaccu gagcgacgcc cugcuccaga accggucccu gacccaccug     2700

aaccucagca agaacagccu gcgcgacgag ggcgugaagu uccugugcga ggcccucggc     2760

cggccggacg ggaaccugca gucccugaac cucagcggcu gcuccuucac ccgcgagggg     2820

ugcggcgagc uggccaacgc gcugagccac aaccacaacg ucaagauccu cgaccugggg     2880

gagaacgacc ugcaggacga cggcgugaag cuccugugcg aggcccugaa gccccaccgg     2940

gcccuccaca cgcugggccu ggccaagugc aaccugacca ccgccugcug ccagcaccuc     3000

uucuccgugc ugagcuccag caagucccug gucaaccuca accugcuggg gaacgagcuc     3060

gacaccgacg gcgugaagau gcugugcaag gcgcugaaga aguccacgug ccgccuccag     3120

aagcuggggu ga                                                         3132


<210>  9049
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP13__Homo_sapiens__CCDS33119.1

<400>  9049
augaacuucu ccgucaucac cugccccaac ggcggcacca accagggccu ccuccccuac       60

cucauggccc ucgaccagua ccagcucgag gaguucaagc ucugccucga gccccagcag      120

cucauggacu ucugguccgc cccccagggc cacuuccccc gcauccccug ggccaaccuc      180

cgcgccgccg acccccucaa ccucuccuuc cuccucgacg agcacuuccc caagggccag      240

gccuggaagg ucguccucgg caucuuccag accaugaacc ucaccucccu cugcgagaag      300

guccgcgccg agaugaagga gaacguccag acccaggagc uccaggaccc cacccaggag      360

gaccucgaga ugcucgaggc cgccgccggc aacaugcaga cccagggcug ccaggacccc      420

aaccaggagg agcucgacga gcucgaggag gagaccggca acguccaggc ccagggcugc      480

caggacccca accaggagga gcccgagaug cucgaggagg ccgaccaccg ccgcaaguac      540

cgcgagaaca ugaaggccga gcuccucgag accugggaca acaucuccug gcccaaggac      600

cacgucuaca uccgcaacac cuccaaggac gagcacgagg agcuccagcg ccuccucgac      660

cccaaccgca cccgcgccca ggcccagacc aucguccucg ucggccgcgc cggcgucggc      720

aagaccaccc ucgccaugca ggccaugcuc cacugggcca acggcguccu cuuccagcag      780

cgcuucuccu acgucuucua ccucuccugc cacaagaucc gcuacaugaa ggagaccacc      840

uucgccgagc ucaucucccu cgacuggccc gacuucgacg cccccaucga ggaguucaug      900

ucccagcccg agaagcuccu cuucaucauc gacggcuucg aggagaucau caucuccgag      960

ucccgcuccg agucccucga cgacggcucc cccugcaccg acugguacca ggagcucccc     1020

gucaccaaga uccuccacuc ccuccucaag aaggagcucg ucccccucgc cacccuccuc     1080

aucaccauca agaccugguu cguccgcgac cucaaggccu cccucgucaa ccccugcuuc     1140

guccagauca ccggcuucac cggcgacgac cuccgcgucu acuucaugcg ccacuucgac     1200

gacuccuccg aggucgagaa gauccuccag cagcuccgca agaacgagac ccucuuccac     1260

uccugcuccg cccccauggu cugcuggacc gucugcuccu gccucaagca gcccaagguc     1320

cgcuacuacg accuccaguc caucacccag accaccaccu cccucuacgc cuacuucuuc     1380

uccaaccucu ucuccaccgc cgaggucgac cucgccgacg acuccuggcc cggccagugg     1440

cgcgcccucu gcucccucgc caucgagggc cucuggucca ugaacuucac cuucaacaag     1500

gaggacaccg agaucgaggg ccucgagguc cccuucaucg acucccucua cgaguucaac     1560

auccuccaga agaucaacga cugcggcggc ugcaccaccu ucacccaccu cuccuuccag     1620

gaguucuucg ccgccauguc cuucguccuc gaggagcccc gcgaguuccc cccccacucc     1680

accaagcccc aggagaugaa gaugcuccuc cagcacgucc uccucgacaa ggaggccuac     1740

uggacccccg ucguccucuu cuucuucggc cuccucaaca agaacaucgc ccgcgagcuc     1800

gaggacaccc uccacugcaa gaucuccccc cgcgucaugg aggagcuccu caaguggggc     1860

gaggagcucg gcaaggccga guccgccucc cuccaguucc acauccuccg ccucuuccac     1920

ugccuccacg agucccagga ggaggacuuc accaagaaga ugcucggccg caucuucgag     1980

gucgaccuca acauccucga ggacgaggag cuccaggccu ccuccuucug ccucaagcac     2040

ugcaagcgcc ucaacaagcu ccgccucucc gucuccuccc acauccucga gcgcgaccuc     2100

gagauccucg agaccuccaa guucgacucc cgcaugcacg ccuggaacuc caucugcucc     2160

acccucguca ccaacgagaa ccuccacgag cucgaccucu ccaacuccaa gcuccacgcc     2220

uccuccguca agggccucug ccucgcccuc aagaaccccc gcugcaaggu ccagaagcuc     2280

accugcaagu ccgucacccc cgaguggguc cuccaggacc ucaucaucgc ccuccagggc     2340

aacuccaagc ucacccaccu caacuucucc uccaacaagc ucggcaugac cgucccccuc     2400

auccucaagg cccuccgcca cuccgccugc aaccucaagu accucugccu cgagaagugc     2460

aaccucuccg ccgccuccug ccaggaccuc gcccucuucc ucaccuccau ccagcacguc     2520

acccgccucu gccucggcuu caaccgccuc caggacgacg gcaucaagcu ccucugcgcc     2580

gcccucaccc accccaagug cgcccucgag cgccucgagc ucugguucug ccagcucgcc     2640

gcccccgccu gcaagcaccu cuccgacgcc cuccuccaga accgcucccu cacccaccuc     2700

aaccucucca agaacucccu ccgcgacgag ggcgucaagu uccucugcga ggcccucggc     2760

cgccccgacg gcaaccucca gucccucaac cucuccggcu gcuccuucac ccgcgagggc     2820

ugcggcgagc ucgccaacgc ccucucccac aaccacaacg ucaagauccu cgaccucggc     2880

gagaacgacc uccaggacga cggcgucaag cuccucugcg aggcccucaa gccccaccgc     2940

gcccuccaca cccucggccu cgccaagugc aaccucacca ccgccugcug ccagcaccuc     3000

uucuccgucc ucuccuccuc caagucccuc gucaaccuca accuccucgg caacgagcuc     3060

gacaccgacg gcgucaagau gcucugcaag gcccucaaga aguccaccug ccgccuccag     3120

aagcucggcu ga                                                         3132


<210>  9050
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP13__Homo_sapiens__CCDS33119.1

<400>  9050
augaacuuca gcgugauuac cugccccaau ggcgggacaa accagggacu gcucccuuac       60

cuuauggccc uggaccaaua ucaguuggag gaauuuaagu uaugucugga gccacagcag      120

cuaauggauu ucugguccgc uccgcaaggu cacuuuccca gaaucccuug ggcaaaucuc      180

agggccgcgg acccacugaa ccuuucuuuc cuguuggaug aacauuuucc caaaggccag      240

gcuuggaagg ucguucucgg gauauuccag acuaugaauc ugacgucacu gugcgagaaa      300

gugcgggccg aaaugaagga gaacguacag acccaagagc uccaggaccc uacacaggaa      360

gauuuagaga ugcuggaagc agccgcugga aauaugcaga cucaaggcug ucaggaccca      420

aaccaggagg agcuugauga auuggaggaa gagaccggua augugcaagc acaggggugc      480

caggacccca accaggaaga accugagaug cuggaagagg ccgaucaccg ccgaaaauac      540

cgugaaaaua ugaaggcuga gcuacucgaa acaugggaca acaucaguug gccaaaggau      600

caugucuaua uuagaaauac cagcaaagac gagcacgagg aacugcaaag gcuucuggau      660

ccgaaccgga cucgcgccca ggcgcagaca aucguguugg uuggcagagc aggagugggc      720

aagaccacgc ucgccaugca ggcuaugcug cauugggcca auggggucuu auuucaacag      780

agguucuccu acguguuuua ucugucuugu cacaaaauuc gguacaugaa ggagacuacc      840

uucgcagaac ucaucucgcu ugacuggccc gacuuugaug cuccuauaga ggaguucaug      900

ucacagccag agaaacuguu guuuaucauu gacggauucg aggaaaucau uaucagcgag      960

agucgcuccg aaucucuaga ugacgguagc cccugcacag auugguauca ggagcugccu     1020

guaacuaaga uacuccacuc ccugcuuaag aaagagcugg uuccauuggc cacccuccug     1080

auuacaauca agaccugguu cgugcgagac uuaaaagcgu cacuggucaa ccccuguuuu     1140

gugcaaauua cgggcuucac uggggaugac cuaagagugu acuuuaugag gcauuucgau     1200

gacaguagcg aagucgagaa gauccuccag cagcugcgga aaaacgaaac acuuuuucac     1260

ucuugcuccg ccccgauggu uuguuggacc gugugcucau guuugaagca gccuaaagua     1320

cguuacuaug aucugcaaag caucacucag acaaccacga gucucuacgc auauuucuuu     1380

ucuaaucugu ucuccaccgc ugagguggac cuugccgacg auagcuggcc cggacagugg     1440

cgcgcucugu gcucguuggc cauugaaggc cucuggucua ugaacuuuac auucaauaag     1500

gaggacacug agauagaagg ucuggagguc ccauuuaucg auuccuuaua cgaguucaac     1560

auucugcaaa agaucaauga cugcggggga uguaccacau uuacucaucu aucauuccag     1620

gaguucuuug cagccaugag uuucgugcuc gaagaaccua gagaguuucc cccacacagc     1680

accaaacccc aggaaaugaa gaugcugcuu cagcacguuu ugcuggauaa agaggcuuau     1740

uggacaccug ugguccucuu cuuuuucggc cuguuaaaca agaauauagc gagggaacug     1800

gaggacaccc uucauugcaa aauuucccca cgggugaugg aagaguugcu caaguggggc     1860

gaggaacugg ggaaggcaga gucugccagc cuacaauuuc acauccugcg acucuuccau     1920

ugucugcacg aaucacagga ggaggauuuu acuaaaaaga ugcuuggacg caucuucgaa     1980

guagacuuga acauucugga ggaugaagag uuacaggcua guuccuuuug ccucaaacau     2040

uguaagagac ugaauaaacu uaggcugagc guuucuucac acaucuugga acgggaccuc     2100

gagauucugg agacgaguaa guucgauagc cgcaugcacg ccuggaacuc cauaugcucu     2160

acacuuguga ccaaugaaaa ccugcaugag cucgaccugu cgaauagcaa gcuacacgca     2220

uccucaguca aagguuugug ucuggccuua aagaacccga gaugcaaagu gcagaagcuc     2280

acuuguaaaa gugucacccc cgaaugggug cugcaagauc uuaucauugc ucugcagggc     2340

aauucuaagc uaacacaucu caacuuuagc uccaacaagc uggggaugac cguuccuuug     2400

auccugaaag ccuuaaggca cucagcaugc aaucucaagu accugugucu ugagaaaugc     2460

aaccugagcg cggcuucuug ccaggacuug gcccucuucc ugacuuccau ccagcacgug     2520

acacgucuau gucugggauu caaucggcuu caagacgaug gcauuaagcu ccugugcgca     2580

gccuugacgc auccaaaaug ugcucuggaa cgauuagagc ucugguuuug ccagcuggcc     2640

gcacccgcuu guaagcaccu uagugacgcc cuguugcaga acagaagccu cacccaucug     2700

aaucuaucua aaaacucccu gagggaugag gguguaaagu uccuuugcga agcgcucggg     2760

cgcccugacg gcaaucugca aucauugaac uuaaguggau guagcuuuac ucgggagggc     2820

ugcggggaac uggccaaugc ucucucgcac aaccauaaug ucaagauacu ggaucuugga     2880

gagaacgacc ugcaggauga cggugugaaa uugcuaugug aagcacugaa gccacacaga     2940

gcccuccaca cacugggccu ugcuaaaugc aauuuaacca cagccuguug ccagcaucug     3000

uucuccguuc ucucuagcuc aaagaguuug gugaaccuga aucuccuggg gaacgagcuu     3060

gauacugacg gagucaaaau gcugugcaag gcauugaaga aauccaccug uaggcuacag     3120

aagcugggcu ga                                                         3132


<210>  9051
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP13__Homo_sapiens__CCDS33119.1

<400>  9051
augaacuuca gcgugaucac cugccccaac ggcggcacca accagggccu gcugcccuac       60

cugauggccc uggaccagua ccagcuggag gaguucaagc ugugccugga gccccagcag      120

cugauggacu ucuggagcgc cccccagggc cacuucccca gaauccccug ggccaaccug      180

agagccgccg acccccugaa ccugagcuuc cugcuggacg agcacuuccc caagggccag      240

gccuggaagg uggugcuggg caucuuccag accaugaacc ugaccagccu gugcgagaag      300

gugagagccg agaugaagga gaacgugcag acccaggagc ugcaggaccc cacccaggag      360

gaccuggaga ugcuggaggc cgccgccggc aacaugcaga cccagggcug ccaggacccc      420

aaccaggagg agcuggacga gcuggaggag gagaccggca acgugcaggc ccagggcugc      480

caggacccca accaggagga gcccgagaug cuggaggagg ccgaccacag aagaaaguac      540

agagagaaca ugaaggccga gcugcuggag accugggaca acaucagcug gcccaaggac      600

cacguguaca ucagaaacac cagcaaggac gagcacgagg agcugcagag acugcuggac      660

cccaacagaa ccagagccca ggcccagacc aucgugcugg ugggcagagc cggcgugggc      720

aagaccaccc uggccaugca ggccaugcug cacugggcca acggcgugcu guuccagcag      780

agauucagcu acguguucua ccugagcugc cacaagauca gauacaugaa ggagaccacc      840

uucgccgagc ugaucagccu ggacuggccc gacuucgacg cccccaucga ggaguucaug      900

agccagcccg agaagcugcu guucaucauc gacggcuucg aggagaucau caucagcgag      960

agcagaagcg agagccugga cgacggcagc cccugcaccg acugguacca ggagcugccc     1020

gugaccaaga uccugcacag ccugcugaag aaggagcugg ugccccuggc cacccugcug     1080

aucaccauca agaccugguu cgugagagac cugaaggcca gccuggugaa ccccugcuuc     1140

gugcagauca ccggcuucac cggcgacgac cugagagugu acuucaugag acacuucgac     1200

gacagcagcg agguggagaa gauccugcag cagcugagaa agaacgagac ccuguuccac     1260

agcugcagcg cccccauggu gugcuggacc gugugcagcu gccugaagca gcccaaggug     1320

agauacuacg accugcagag caucacccag accaccacca gccuguacgc cuacuucuuc     1380

agcaaccugu ucagcaccgc cgagguggac cuggccgacg acagcuggcc cggccagugg     1440

agagcccugu gcagccuggc caucgagggc cuguggagca ugaacuucac cuucaacaag     1500

gaggacaccg agaucgaggg ccuggaggug cccuucaucg acagccugua cgaguucaac     1560

auccugcaga agaucaacga cugcggcggc ugcaccaccu ucacccaccu gagcuuccag     1620

gaguucuucg ccgccaugag cuucgugcug gaggagccca gagaguuccc cccccacagc     1680

accaagcccc aggagaugaa gaugcugcug cagcacgugc ugcuggacaa ggaggccuac     1740

uggacccccg uggugcuguu cuucuucggc cugcugaaca agaacaucgc cagagagcug     1800

gaggacaccc ugcacugcaa gaucagcccc agagugaugg aggagcugcu gaaguggggc     1860

gaggagcugg gcaaggccga gagcgccagc cugcaguucc acauccugag acuguuccac     1920

ugccugcacg agagccagga ggaggacuuc accaagaaga ugcugggcag aaucuucgag     1980

guggaccuga acauccugga ggacgaggag cugcaggcca gcagcuucug ccugaagcac     2040

ugcaagagac ugaacaagcu gagacugagc gugagcagcc acauccugga gagagaccug     2100

gagauccugg agaccagcaa guucgacagc agaaugcacg ccuggaacag caucugcagc     2160

acccugguga ccaacgagaa ccugcacgag cuggaccuga gcaacagcaa gcugcacgcc     2220

agcagcguga agggccugug ccuggcccug aagaacccca gaugcaaggu gcagaagcug     2280

accugcaaga gcgugacccc cgagugggug cugcaggacc ugaucaucgc ccugcagggc     2340

aacagcaagc ugacccaccu gaacuucagc agcaacaagc ugggcaugac cgugccccug     2400

auccugaagg cccugagaca cagcgccugc aaccugaagu accugugccu ggagaagugc     2460

aaccugagcg ccgccagcug ccaggaccug gcccuguucc ugaccagcau ccagcacgug     2520

accagacugu gccugggcuu caacagacug caggacgacg gcaucaagcu gcugugcgcc     2580

gcccugaccc accccaagug cgcccuggag agacuggagc ugugguucug ccagcuggcc     2640

gcccccgccu gcaagcaccu gagcgacgcc cugcugcaga acagaagccu gacccaccug     2700

aaccugagca agaacagccu gagagacgag ggcgugaagu uccugugcga ggcccugggc     2760

agacccgacg gcaaccugca gagccugaac cugagcggcu gcagcuucac cagagagggc     2820

ugcggcgagc uggccaacgc ccugagccac aaccacaacg ugaagauccu ggaccugggc     2880

gagaacgacc ugcaggacga cggcgugaag cugcugugcg aggcccugaa gccccacaga     2940

gcccugcaca cccugggccu ggccaagugc aaccugacca ccgccugcug ccagcaccug     3000

uucagcgugc ugagcagcag caagagccug gugaaccuga accugcuggg caacgagcug     3060

gacaccgacg gcgugaagau gcugugcaag gcccugaaga agagcaccug cagacugcag     3120

aagcugggcu ga                                                         3132


<210>  9052
<211>  3132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP13__Homo_sapiens__CCDS33119.1

<400>  9052
augaacuuca gcgugauuac cugccccaau ggcgggacaa accagggacu gcucccuuac       60

cugauggccc uugaccaaua ucagcuggag gaauuuaagc ucugucugga gccgcagcag      120

cuuauggauu ucugguccgc uccccaaggc cacuuuccua gaauccccug ggccaaucug      180

cgggcggcug acccucucaa ccugucuuuc cugcucgaug aacauuuucc caaagggcag      240

gccuggaagg ucguucuggg aaucuuccag acgaugaauc uuaccagccu gugcgagaaa      300

gugcgcgccg aaaugaagga gaacgugcag acacaagagc uccaggaccc uacccaggaa      360

gaucuggaga ugcuugaagc ugccgcuggc aauaugcaga cacaagggug ucaggacccg      420

aaccaggagg agcuggauga acucgaggaa gagaccggaa auguccaagc ccagggcugc      480

caggacccca accaggaaga accugagaug cuggaagagg cggaucacag acggaaauac      540

cgcgaaaaua ugaaggccga gcugcucgaa acaugggaca acauuuccug gcccaaggau      600

cauguguaua ucagaaauac cucuaaagac gagcacgagg aacugcaacg gcuucuggau      660

ccuaaccgca cgagagcuca ggcccagacc auuguucucg ugggccgggc uggggucgga      720

aagacaaccc uggccaugca ggcgaugcuu cauugggcca auggcgugcu guuucaacag      780

cgcuucagcu acguuuucua ucucuccugu cacaaaauca gauacaugaa ggagacaacc      840

uucgcugaac ugaucucucu ggacuggccc gacuuugaug ccccgauuga ggaauuuaug      900

agccagccug agaaacuccu guuuaucauu gacggguucg aggaaaucau uaucuccgag      960

agccggucug aaucccuuga ugacggaagc cccugcacgg auugguauca ggagcugccu     1020

gugacaaaga uucuccacuc ucugcuuaag aaagagcugg ucccccucgc uacccugcug     1080

aucacaauca agaccugguu cgugcgcgac cucaaagccu cccuggugaa ccccuguuuu     1140

guccaaauua ccggcuucac aggggaugac cuuagaguuu acuuuaugcg gcauuucgau     1200

gacagcucug aaguggagaa gauccugcag cagcuccgca aaaacgaaac gcuguuucac     1260

uccugcagcg ccccuauggu guguuggacc gucugcuccu gucugaagca gccgaaagug     1320

agauacuaug aucuucaauc uauuacacag accacaacca gccucuacgc uuauuucuuu     1380

uccaaucugu ucagcacggc ggagguugac cuggccgacg auucuuggcc cggacagugg     1440

cgggcucucu gcucccuggc caucgaaggc cuuuggagca ugaacuuuac auucaauaag     1500

gaggacaccg agauugaagg ccuggaggug ccuuuuaucg auucucucua cgaguucaac     1560

auccugcaaa agauuaauga cugcggggga uguaccacau uuacccaucu gagcuuccag     1620

gaguucuuug ccgcuauguc cuucguccuu gaagaaccca gagaguuucc uccccacucu     1680

acaaaaccgc aggaaaugaa gaugcuccug cagcacgugc ugcucgauaa agaggccuau     1740

uggacgccug uugugcuguu cuuuuucggc cuucugaaca agaauaucgc gcgcgaacuc     1800

gaggacaccc ugcauugcaa aauuagcccc cgggucaugg aggagcugcu uaagugggga     1860

gaggaacucg ggaaggcuga guccgccagc cugcaauuuc acauccugag acucuuccau     1920

ugucugcacg aaucucagga ggaggauuuu accaaaaaga ugcuuggccg cauuuucgaa     1980

guggaccuga acauccucga ggaugaggaa cugcaggccu ccagcuuuug ccugaaacau     2040

uguaagcggc uuaauaaacu cagacugucu gucuccagcc acauccugga acgcgaccuc     2100

gagauucugg agacauccaa guucgauucu cggaugcacg cuuggaacag caucugcucc     2160

acacuuguga ccaaugaaaa ccugcaugag cucgaccugu cuaauagcaa gcugcacgcc     2220

uccagcguua aagggcuuug ucuggcucuc aagaacccua gaugcaaagu gcagaagcug     2280

acguguaaau cugucacccc cgaaugggug cuccaagauc ugauuaucgc ccuucaggga     2340

aauuccaagc ugacacaucu caacuuuagc ucuaacaagc ugggcaugac cguuccucug     2400

auucuuaaag cgcugcgcca cuccgccugc aaucucaagu accugugucu cgagaaaugc     2460

aaccugagcg cugccucuug ccaggaccuu gcucuguucc ucacaagcau ccagcacgug     2520

acccggcugu gucugggcuu caauagacuu caagacgaug ggauuaagcu gcucugcgcc     2580

gcgcugacgc aucccaaaug ugcccucgaa cgccuggagc uuugguuuug ccagcuggcu     2640

gccccggcuu guaagcaccu guccgacgcc cuccugcaga accggagccu uacacaucug     2700

aaucucucua aaaacucccu gagagaugag ggagucaagu uccucugcga agcccugggc     2760

cggccugacg ggaaucuuca aagccugaac cuguccggau guucuuuuac ccgcgagggc     2820

ugcggggaac ucgcuaaugc gcugagccac aaccauaaug ugaagauccu ugaucugggc     2880

gagaacgacc uccaggauga cggagugaaa cugcucugug aagcccugaa gccccacaga     2940

gcccuucaca cacugggccu ggcuaaaugc aaucucacca ccgccuguug ccagcaucug     3000

uucuccguuc uuucuagcuc caagucucug gucaaccuca aucugcucgg gaacgagcug     3060

gauacagacg gagugaaaau gcuuugcaag gcucugaaga aaagcacgug ucggcugcag     3120

aagcucggcu ga                                                         3132


<210>  9053
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP2__Homo_sapiens__Q8WY49

<400>  9053

Met Ser Pro Leu Ser Leu Ser Val Ser Asn Pro Arg Leu Lys Ser Gln 
1               5                   10                  15      


Arg Cys Ile Thr Ala Val Arg Thr His Arg Phe Gly Phe Ala Phe Phe 
            20                  25                  30          


Leu Trp Leu Ile Ser Arg Leu Trp Asn Cys Asp Ile Thr Ser Asp Gly 
        35                  40                  45              


Cys Cys Asp Leu Thr Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu Cys 
    50                  55                  60                  


Leu Asp Leu Gly Leu Asn His Ile Gly Val Lys Gly Met Lys Phe Leu 
65                  70                  75                  80  


Cys Glu Ala Leu Arg Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp Leu 
                85                  90                  95      


Trp Gly Cys Ser Ile Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser Ala 
            100                 105                 110         


Leu Ser Cys Asn Gln Ser Leu Val Thr Leu Asp Leu Gly Gln Asn Pro 
        115                 120                 125             


Leu Gly Ser Ser Gly Val Lys Met Leu Phe Glu Thr Leu Thr Cys Ser 
    130                 135                 140                 


Ser Gly Thr Leu Arg Thr Leu Arg Leu Lys Ile Asp Asp Phe Asn Asp 
145                 150                 155                 160 


Glu Leu Asn Lys Leu Leu Glu Glu Ile Glu Glu Lys Asn Pro Gln Leu 
                165                 170                 175     


Ile Ile Asp Thr Glu Lys His His Pro Trp Ala Glu Arg Pro Ser Ser 
            180                 185                 190         


His Asp Phe Met Ile 
        195         


<210>  9054
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP2__Homo_sapiens__AAG23171

<400>  9054
augucaccac ugucucuaag ugugucuaac ccacggcuca agagucaaag gugcaucaca       60

gcagugagaa cucacagguu cggguuugcu uucuuccugu gguugauuuc uaggcuuugg      120

aacugcgaca uaacuagcga uggcugcugc gaucucacaa agcuucucca agaaaaauca      180

agccuguugu guuuggaucu ggggcugaau cacauaggag uuaagggaau gaaguuccug      240

ugugaggcuu ugaggaaacc acugugcaac uugagauguc ugugguugug gggauguucc      300

aucccuccgu ucaguuguga agaccucugc ucugcccuca gcugcaacca gagccucguc      360

acucuggacc ugggucagaa ucccuugggg ucuaguggag ugaagaugcu guuugaaacc      420

uugacauguu ccaguggcac ccuccggaca cucagguuga aaauagauga cuuuaaugau      480

gaacucaaua agcugcugga agaaauagaa gaaaaaaacc cacaacugau uauugauacu      540

gagaaacauc aucccugggc agaaaggccu ucuucucaug acuucaugau cuga            594


<210>  9055
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP2__Homo_sapiens__AAG23171

<400>  9055
augagccccc ugucccucag cguguccaac ccgcgccuca agagccagcg gugcaucacc       60

gccguccgca cccaccgguu cggcuucgcc uucuuccugu ggcugaucuc ccgccugugg      120

aacugcgaca ucacgagcga cgggugcugc gaccugacca agcuccugca ggagaagucc      180

agccugcucu gccuggaccu gggccucaac cacaucgggg ugaagggcau gaaguuccug      240

ugcgaggcgc ugcggaagcc ccucugcaac cugcgcugcc uguggcucug ggggugcucc      300

aucccgcccu ucagcugcga ggaccugugc uccgcccuga gcugcaacca gucccucgug      360

acccuggacc ugggccagaa cccccucggc agcuccgggg ucaagaugcu guucgagacc      420

cugacgugca gcuccggcac ccuccggacc cugcgccuga agaucgacga cuucaacgac      480

gagcucaaca agcugcugga ggagaucgag gagaagaacc cccagcucau caucgacacc      540

gagaagcacc accccugggc cgagcggccc agcucccacg acuucaugau cuga            594


<210>  9056
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP2__Homo_sapiens__AAG23171

<400>  9056
augucccccc ucucccucuc cgucuccaac ccccgccuca agucccagcg cugcaucacc       60

gccguccgca cccaccgcuu cggcuucgcc uucuuccucu ggcucaucuc ccgccucugg      120

aacugcgaca ucaccuccga cggcugcugc gaccucacca agcuccucca ggagaagucc      180

ucccuccucu gccucgaccu cggccucaac cacaucggcg ucaagggcau gaaguuccuc      240

ugcgaggccc uccgcaagcc ccucugcaac cuccgcugcc ucuggcucug gggcugcucc      300

aucccccccu ucuccugcga ggaccucugc uccgcccucu ccugcaacca gucccucguc      360

acccucgacc ucggccagaa cccccucggc uccuccggcg ucaagaugcu cuucgagacc      420

cucaccugcu ccuccggcac ccuccgcacc cuccgccuca agaucgacga cuucaacgac      480

gagcucaaca agcuccucga ggagaucgag gagaagaacc cccagcucau caucgacacc      540

gagaagcacc accccugggc cgagcgcccc uccucccacg acuucaugau cuga            594


<210>  9057
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP2__Homo_sapiens__AAG23171

<400>  9057
augagccccc ugucccucuc ugugucaaac ccuagacuua agagucagag gugcaucacc       60

gccguccgga cacaccgcuu cggcuuugcu uucuuucugu gguugauuag ccgauuaugg      120

aauugugaca uaacuuccga ugggugcugu gaccugacga aacuacucca agagaagucu      180

ucgcugcuuu gccuggauuu gggacucaac cauaucggug uuaaaggcau gaaguuccug      240

ugugaagcac ugcguaaacc acucugcaau uuaagauguc uguggcuuug ggggugcuca      300

auuccgcccu uuagcuguga ggacuugugc agugcccugu ccuguaacca gucucuagug      360

acccucgauc ugggacagaa uccucuuggc agcuccggug uaaagaugcu guucgaaaca      420

uugacuugcu caagugggac ccucaggaca cugcgguuaa agaucgacga uuuuaacgac      480

gagcugaaua aacuccuuga agagauugag gaaaagaacc cacagcugau cauagauacc      540

gagaaacacc aucccugggc ggaacgcccu agcucucacg acuucaugau cuga            594


<210>  9058
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP2__Homo_sapiens__AAG23171

<400>  9058
augagccccc ugagccugag cgugagcaac cccagacuga agagccagag augcaucacc       60

gccgugagaa cccacagauu cggcuucgcc uucuuccugu ggcugaucag cagacugugg      120

aacugcgaca ucaccagcga cggcugcugc gaccugacca agcugcugca ggagaagagc      180

agccugcugu gccuggaccu gggccugaac cacaucggcg ugaagggcau gaaguuccug      240

ugcgaggccc ugagaaagcc ccugugcaac cugagaugcc uguggcugug gggcugcagc      300

aucccccccu ucagcugcga ggaccugugc agcgcccuga gcugcaacca gagccuggug      360

acccuggacc ugggccagaa cccccugggc agcagcggcg ugaagaugcu guucgagacc      420

cugaccugca gcagcggcac ccugagaacc cugagacuga agaucgacga cuucaacgac      480

gagcugaaca agcugcugga ggagaucgag gagaagaacc cccagcugau caucgacacc      540

gagaagcacc accccugggc cgagagaccc agcagccacg acuucaugau cuga            594


<210>  9059
<211>  594
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP2__Homo_sapiens__AAG23171

<400>  9059
augagccccc ugucccucuc ugugagcaac ccuagacuga agucccagcg gugcaucacc       60

gccguccgca cacacagauu cggcuuugcu uucuuucuuu ggcugauuuc ucggcucugg      120

aauugugaca ucacgagcga ugggugcugu gaccugacca aacuucugca agagaagucc      180

ucucuccugu gccuggaucu cggacugaac cauauuggcg uuaaagggau gaaguuccuu      240

ugugaagccc ugcgcaaacc gcucugcaau cugagauguc uuuggcugug gggaugcagc      300

auucccccuu uuuccuguga ggaccucugc agcgcgcugu cuuguaacca gucccuggug      360

acacucgauc ugggccagaa uccccuuggg agcucuggag ugaagaugcu guucgaaacc      420

cucacaugcu ccagcggcac ccugcggaca cuucgccuga agaucgacga uuuuaacgac      480

gagcucaaua aacugcugga agagaucgag gaaaagaacc cucagcucau cauugauacc      540

gagaaacacc aucccugggc ugaaagaccu ucuucccacg acuucaugau cuga            594


<210>  9060
<211>  1062
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP2__Homo_sapiens__Q9NX02

<400>  9060

Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr 
            20                  25                  30          


Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp 
        35                  40                  45              


Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp 
    50                  55                  60                  


Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His 
65                  70                  75                  80  


Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala 
                85                  90                  95      


Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg 
            100                 105                 110         


Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys 
        115                 120                 125             


Thr Glu Ala Gln Ala Phe Thr Glu Thr Lys Gly Asn Val Ile Cys Leu 
    130                 135                 140                 


Gly Lys Glu Val Phe Lys Gly Lys Lys Pro Asp Lys Asp Asn Arg Cys 
145                 150                 155                 160 


Arg Tyr Ile Leu Lys Thr Lys Phe Arg Glu Met Trp Lys Ser Trp Pro 
                165                 170                 175     


Gly Asp Ser Lys Glu Val Gln Val Met Ala Glu Arg Tyr Lys Met Leu 
            180                 185                 190         


Ile Pro Phe Ser Asn Pro Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr 
        195                 200                 205             


Val Val Leu Tyr Gly Pro Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln 
    210                 215                 220                 


Lys Leu Met Leu Asp Trp Ala Glu Asp Asn Leu Ile His Lys Phe Lys 
225                 230                 235                 240 


Tyr Ala Phe Tyr Leu Ser Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys 
                245                 250                 255     


Ser Phe Ala Glu Leu Val Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp 
            260                 265                 270         


Ile Pro His Ile Leu Ala Gln Ala Arg Lys Ile Leu Phe Val Ile Asp 
        275                 280                 285             


Gly Phe Asp Glu Leu Gly Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile 
    290                 295                 300                 


Cys Gly Asp Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Leu Asn Arg Val Met Leu Pro Lys Ala Ala Leu Leu Val Thr Thr 
                325                 330                 335     


Arg Pro Arg Ala Leu Arg Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile 
            340                 345                 350         


Tyr Ile Arg Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe 
        355                 360                 365             


Leu Arg His Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu 
    370                 375                 380                 


Met Arg Ser Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val 
385                 390                 395                 400 


Cys Trp Ile Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu 
                405                 410                 415     


Asp Pro Val Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe 
            420                 425                 430         


Leu Cys Ser Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg 
        435                 440                 445             


Thr Leu Ser Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Thr Ser Val 
    450                 455                 460                 


Leu His Arg Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu 
465                 470                 475                 480 


Arg Leu Phe Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys 
                485                 490                 495     


Gly Cys Tyr Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala 
            500                 505                 510         


Leu Phe Tyr Thr Leu Glu Lys Glu Glu Glu Glu Asp Arg Asp Gly His 
        515                 520                 525             


Thr Trp Asp Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Val Glu Arg 
    530                 535                 540                 


Leu Arg Asn Pro Asp Leu Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu 
545                 550                 555                 560 


Ala Asn Glu Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg 
                565                 570                 575     


Met Ser Pro Asp Ile Lys Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys 
            580                 585                 590         


Lys Gly Gly His Ser Thr Val Thr Asp Leu Gln Glu Leu Leu Gly Cys 
        595                 600                 605             


Leu Tyr Glu Ser Gln Glu Glu Glu Leu Val Lys Glu Val Met Ala Gln 
    610                 615                 620                 


Phe Lys Glu Ile Ser Leu His Leu Asn Ala Val Asp Val Val Pro Ser 
625                 630                 635                 640 


Ser Phe Cys Val Lys His Cys Arg Asn Leu Gln Lys Met Ser Leu Gln 
                645                 650                 655     


Val Ile Lys Glu Asn Leu Pro Glu Asn Val Thr Ala Ser Glu Ser Asp 
            660                 665                 670         


Ala Glu Val Glu Arg Ser Gln Asp Asp Gln His Met Leu Pro Phe Trp 
        675                 680                 685             


Thr Asp Leu Cys Ser Ile Phe Gly Ser Asn Lys Asp Leu Met Gly Leu 
    690                 695                 700                 


Ala Ile Asn Asp Ser Phe Leu Ser Ala Ser Leu Val Arg Ile Leu Cys 
705                 710                 715                 720 


Glu Gln Ile Ala Ser Asp Thr Cys His Leu Gln Arg Val Val Phe Lys 
                725                 730                 735     


Asn Ile Ser Pro Ala Asp Ala His Arg Asn Leu Cys Leu Ala Leu Arg 
            740                 745                 750         


Gly His Lys Thr Val Thr Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp 
        755                 760                 765             


Asp Met Phe Pro Ala Leu Cys Glu Val Leu Arg His Pro Glu Cys Asn 
    770                 775                 780                 


Leu Arg Tyr Leu Gly Leu Val Ser Cys Ser Ala Thr Thr Gln Gln Trp 
785                 790                 795                 800 


Ala Asp Leu Ser Leu Ala Leu Glu Val Asn Gln Ser Leu Thr Cys Val 
                805                 810                 815     


Asn Leu Ser Asp Asn Glu Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr 
            820                 825                 830         


Thr Thr Leu Arg His Pro Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu 
        835                 840                 845             


Asn Cys His Leu Thr Glu Ala Asn Cys Lys Asp Leu Ala Ala Val Leu 
    850                 855                 860                 


Val Val Ser Arg Glu Leu Thr His Leu Cys Leu Ala Lys Asn Pro Ile 
865                 870                 875                 880 


Gly Asn Thr Gly Val Lys Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu 
                885                 890                 895     


Cys Lys Leu Gln Thr Leu Val Leu Trp Asn Cys Asp Ile Thr Ser Asp 
            900                 905                 910         


Gly Cys Cys Asp Leu Thr Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu 
        915                 920                 925             


Cys Leu Asp Leu Gly Leu Asn His Ile Gly Val Lys Gly Met Lys Phe 
    930                 935                 940                 


Leu Cys Glu Ala Leu Arg Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp 
945                 950                 955                 960 


Leu Trp Gly Cys Ser Ile Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser 
                965                 970                 975     


Ala Leu Ser Cys Asn Gln Ser Leu Val Thr Leu Asp Leu Gly Gln Asn 
            980                 985                 990         


Pro Leu Gly Ser Ser Gly Val Lys Met Leu Phe Glu Thr Leu Thr Cys 
        995                 1000                1005            


Ser Ser Gly Thr Leu Arg Thr Leu Arg Leu Lys Ile Asp Asp Phe Asn 
    1010                1015                1020                


Asp Glu Leu Asn Lys Leu Leu Glu Glu Ile Glu Glu Lys Asn Pro Gln 
1025                1030                1035                1040


Leu Ile Ile Asp Thr Glu Lys His His Pro Trp Ala Glu Arg Pro Ser 
                1045                1050                1055    


Ser His Asp Phe Met Ile 
            1060        


<210>  9061
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP2__Homo_sapiens__AAG30289

<400>  9061
auggugucuu cggcgcagau gggcuucaac cugcaggcuc uccuggagca gcucagccag       60

gaugaguuga gcaaguucaa guaucugauc acgaccuucu cccuggcaca cgagcuccag      120

aagauccccc acaaggaggu agacaaggcu gaugggaagc aacugguaga aauccucacc      180

acccauugug acagcuacug gguggagaug gcgagccucc aggucuuuga aaagaugcac      240

cgaauggauc ugucugagag agcaaaggau gaagucagag aagcagcuuu gaaauccuuu      300

aauaaaagga aaccucuauc auuagggaua acacggaaag aacgaccacc ucuagacgug      360

gacgaaaugc uggagcgcuu caaaacagaa gcacaagcgu uuacagaaac gaaaggaaau      420

gucaucugcc uggguaaaga agucuuuaaa ggaaaaaagc cagacaaaga caauaggugc      480

agguauauau ugaagacgaa guuccgggag auguggaaga gcuggccugg agauagcaaa      540

gagguccagg uuauggcuga gagauacaag augcugaucc cauucagcaa ccccagggug      600

cuucccgggc ccuucucaua cacgguggug cuguaugguc cugcaggccu ugggaaaacc      660

acgcuggccc agaaacuaau gcuagacugg gcagaggaca accucaucca caaauucaaa      720

uaugcguucu accucagcug cagggagcuc agccgccugg gcccgugcag uuuugcagag      780

cuggucuuca gggacuggcc ugaauugcag gaugacauuc cacacauccu agcccaagca      840

cggaaaaucu uguucgugau ugacggcuuu gaugagcugg gagccgcacc uggggcgcug      900

aucgaggaca ucugcgggga cugggagaag aagaagccgg ugcccguccu ccuggggagu      960

uugcugaaca gggugauguu acccaaggcc gcccugcugg ucaccacgcg gcccagggcc     1020

cugagggacc uccggauccu ggcggaggag ccgaucuaca uaagggugga gggcuuccug     1080

gaggaggaca ggagggccua uuuccugaga cacuuuggag acgaggacca agccaugcgu     1140

gccuuugagc uaaugaggag caacgcggcc cuguuccagc ugggcucggc ccccgcggug     1200

ugcuggaucg ugugcacgac ucugaagcug cagauggaga agggggagga cccggucccc     1260

accugccuca cccgcacggg gcuguuccug cguuuccucu gcagccgguu cccgcagggc     1320

gcacagcugc ggggcgcgcu gcggacgcug agccuccugg ccgcgcaggg ccugugggcg     1380

cagacguccg ugcuucaccg agaggaucug gaaaggcucg gggugcagga guccgaccuc     1440

cgucuguucc uggacggaga cauccuccgc caggacagag ucuccaaagg cugcuacucc     1500

uucauccacc ucagcuucca gcaguuucuc acugcccugu ucuacacccu ggagaaggag     1560

gaggaagagg auagggacgg ccacaccugg gacauugggg acguacagaa gcugcuuucc     1620

ggaguagaaa gacucaggaa ccccgaccug auccaagcag gcuacuacuc cuuuggccuc     1680

gcuaacgaga agagagccaa ggaguuggag gccacuuuug gcugccggau gucaccggac     1740

aucaaacagg aauugcugcg augcgacaua aguuguaagg guggacauuc aacggugaca     1800

gaccugcagg agcuccucgg cugucuguac gagucucagg aggaggagcu ggugaaggag     1860

gugauggcuc aguucaaaga aauaucccug cacuuaaaug caguagacgu ugugccaucu     1920

ucauucugcg ucaagcacug ucgaaaccug cagaaaaugu cacugcaggu aauaaaggag     1980

aaucucccgg agaaugucac ugcgucugaa ucagacgccg agguugagag aucccaggau     2040

gaucagcaca ugcuuccuuu cuggacggac cuuuguucca uauuuggauc aaauaaggau     2100

cugauggguc uagcaaucaa ugauagcuuu cucagugccu cccuaguaag gauccugugu     2160

gaacaaauag ccucugacac cugucaucuc cagagagugg uguucaaaaa cauuucccca     2220

gcugaugcuc aucggaaccu cugccuagcu cuucgagguc acaagacugu aacguaucug     2280

acccuucaag gcaaugacca ggaugauaug uuucccgcau ugugugaggu cuugagacau     2340

ccagaaugua accugcgaua ucucggguug gugucuuguu ccgcuaccac ucagcagugg     2400

gcugaucucu ccuuggcccu ugaagucaac cagucccuga cgugcguaaa ccucuccgac     2460

aaugagcuuc uggaugaggg ugcuaaguug cuguacacaa cuuugagaca ccccaagugc     2520

uuucugcaga gguugucguu ggaaaacugu caccuuacag aagccaauug caaggaccuu     2580

gcugcugugu ugguugucag ccgggagcug acacaccugu gcuuggccaa gaaccccauu     2640

gggaauacag gggugaaguu ucugugugag ggcuugaggu accccgagug uaaacugcag     2700

accuuggugc uuuggaacug cgacauaacu agcgauggcu gcugcgaucu cacaaagcuu     2760

cuccaagaaa aaucaagccu guuguguuug gaucuggggc ugaaucacau aggaguuaag     2820

ggaaugaagu uccuguguga ggcuuugagg aaaccacugu gcaacuugag augucugugg     2880

uuguggggau guuccauccc uccguucagu ugugaagacc ucugcucugc ccucagcugc     2940

aaccagagcc ucgucacucu ggaccugggu cagaaucccu uggggucuag uggagugaag     3000

augcuguuug aaaccuugac auguuccagu ggcacccucc ggacacucag guugaaaaua     3060

gaugacuuua augaugaacu caauaagcug cuggaagaaa uagaagaaaa aaacccacaa     3120

cugauuauug auacugagaa acaucauccc ugggcagaaa ggccuucuuc ucaugacuuc     3180

augaucuga                                                             3189


<210>  9062
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP2__Homo_sapiens__AAG30289

<400>  9062
auggugagcu ccgcccagau gggcuucaac cugcaggccc uccuggagca gcugagccag       60

gacgagcucu ccaaguucaa guaccugauc accaccuuca gccuggcgca cgagcuccag      120

aagauccccc acaaggaggu cgacaaggcc gacgggaagc agcuggugga gauccugacg      180

acccacugcg acuccuacug gguggagaug gccagccucc aggucuucga gaagaugcac      240

cgcauggacc uguccgagcg ggccaaggac gaggugcgcg aggccgcgcu caagagcuuc      300

aacaagcgga agccgcucuc ccugggcauc acccgcaagg agcggccgcc ccuggacgug      360

gacgagaugc ucgagcgcuu caagaccgag gcccaggccu ucacggagac caaggggaac      420

gucaucugcc ugggcaagga gguguucaag gggaagaagc ccgacaagga caaccggugc      480

cgcuacaucc ugaagaccaa guuccgggag auguggaagu ccuggcccgg cgacagcaag      540

gaggugcagg ucauggccga gcgcuacaag augcucaucc ccuucagcaa cccccgggug      600

cugcccggcc cguucuccua caccgugguc cuguacgggc ccgcgggccu cgggaagacg      660

acccuggccc agaagcugau gcucgacugg gccgaggaca accugaucca caaguucaag      720

uacgccuucu accugagcug ccgcgagcuc ucccggcugg gccccugcag cuucgccgag      780

cugguguucc gcgacuggcc cgagcuccag gacgacaucc cgcacauccu ggcgcaggcc      840

cggaagaucc uguucgugau cgacggguuc gacgagcucg gcgccgcccc cggcgcccug      900

aucgaggaca ucugcgggga cugggagaag aagaagcccg uccccgugcu gcucggcucc      960

cugcugaacc gcgugaugcu cccgaaggcg gcccugcugg ucaccacccg gccccgcgcc     1020

cuccgggacc ugcgcauccu ggccgaggag cccaucuaca uccgggugga gggguuccuc     1080

gaggaggacc gccgcgccua cuuccugcgg cacuucggcg acgaggacca ggcgaugcgc     1140

gccuucgagc ugaugcggag caacgccgcc cucuuccagc ugggcuccgc ccccgcggug     1200

ugcuggaucg ucugcacgac ccugaagcug cagauggaga agggggagga cccggugccg     1260

accugccuca cccgcacggg ccuguuccug cgguuccucu gcagccgcuu cccccagggg     1320

gcccagcugc ggggcgcccu gcgcacccuc agccugcugg ccgcgcaggg gcucugggcc     1380

cagaccuccg ugcugcaccg ggaggaccug gagcgccucg gcguccagga gagcgaccug     1440

cggcuguucc ucgacggcga cauccugcgc caggaccggg uguccaaggg gugcuacagc     1500

uucauccacc uguccuucca gcaguuccuc accgcccugu ucuacacgcu ggagaaggag     1560

gaggaggagg accgcgacgg ccacaccugg gacaucgggg acguccagaa gcuccugagc     1620

ggcguggagc ggcugcgcaa ccccgaccuc auccaggccg gguacuacuc cuucggccug     1680

gccaacgaga agcgggcgaa ggagcuggag gccaccuucg gcugccgcau gagccccgac     1740

aucaagcagg agcuccugcg gugcgacauc uccugcaagg gcgggcacag caccgugacg     1800

gaccugcagg agcuccuggg gugccuguac gagucccagg aggaggagcu cgucaaggag     1860

gugauggccc aguucaagga gaucagccug caccugaacg ccguggacgu cgugcccucc     1920

agcuucugcg ugaagcacug ccgcaaccuc cagaagaugu cccugcaggu caucaaggag     1980

aaccugcccg agaacgugac cgccagcgag uccgacgcgg agguggagcg cagccaggac     2040

gaccagcaca ugcuccccuu cuggaccgac cugugcucca ucuucggcag caacaaggac     2100

cugauggggc ucgccaucaa cgacagcuuc cuguccgcca gccugguccg gauccucugc     2160

gagcagaucg ccuccgacac gugccaccuc cagcgcgugg uguucaagaa caucagcccg     2220

gccgacgcgc accggaaccu gugccuggcc cugcgcggcc acaagaccgu caccuaccug     2280

acccuccagg gcaacgacca ggacgacaug uuccccgccc ugugcgaggu gcugcggcac     2340

cccgagugca accuccgcua ccuggggcug guguccugca gcgccaccac gcagcagugg     2400

gcggaccucu cccuggcccu ggaggucaac cagagccuga ccugcgugaa ccuguccgac     2460

aacgagcugc ucgacgaggg cgccaagcug cuguacacca cccuccggca cccgaagugc     2520

uuccugcagc gccugagccu cgagaacugc caccugacgg aggccaacug caaggaccug     2580

gccgcggugc ucgucguguc ccgggagcug acccaccugu gccucgccaa gaaccccauc     2640

gggaacaccg gcgugaaguu ccugugcgag ggccugcgcu accccgagug caagcuccag     2700

acccuggucc uguggaacug cgacaucacc agcgacgggu gcugcgaccu cacgaagcug     2760

cugcaggaga aguccagccu ccugugccug gaccucggcc ugaaccacau cggggugaag     2820

ggcaugaagu uccugugcga ggcccuccgg aagccccugu gcaaccugcg cugccucugg     2880

cugugggggu gcuccauccc gcccuucagc ugcgaggacc ugugcuccgc ccugagcugc     2940

aaccagagcc ucgugacccu ggaccugggc cagaaccccc ucggcuccag cggggucaag     3000

augcuguucg agacccugac cugcuccagc ggcacgcucc ggacccugcg ccugaagauc     3060

gacgacuuca acgacgagcu caacaagcug cuggaggaga ucgaggagaa gaacccccag     3120

cucaucaucg acaccgagaa gcaccacccg ugggccgagc ggcccuccag ccacgacuuc     3180

augaucuga                                                             3189


<210>  9063
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP2__Homo_sapiens__AAG30289

<400>  9063
auggucuccu ccgcccagau gggcuucaac cuccaggccc uccucgagca gcucucccag       60

gacgagcucu ccaaguucaa guaccucauc accaccuucu cccucgccca cgagcuccag      120

aagauccccc acaaggaggu cgacaaggcc gacggcaagc agcucgucga gauccucacc      180

acccacugcg acuccuacug ggucgagaug gccucccucc aggucuucga gaagaugcac      240

cgcauggacc ucuccgagcg cgccaaggac gagguccgcg aggccgcccu caaguccuuc      300

aacaagcgca agccccucuc ccucggcauc acccgcaagg agcgcccccc ccucgacguc      360

gacgagaugc ucgagcgcuu caagaccgag gcccaggccu ucaccgagac caagggcaac      420

gucaucugcc ucggcaagga ggucuucaag ggcaagaagc ccgacaagga caaccgcugc      480

cgcuacaucc ucaagaccaa guuccgcgag auguggaagu ccuggcccgg cgacuccaag      540

gagguccagg ucauggccga gcgcuacaag augcucaucc ccuucuccaa cccccgcguc      600

cuccccggcc ccuucuccua caccgucguc cucuacggcc ccgccggccu cggcaagacc      660

acccucgccc agaagcucau gcucgacugg gccgaggaca accucaucca caaguucaag      720

uacgccuucu accucuccug ccgcgagcuc ucccgccucg gccccugcuc cuucgccgag      780

cucgucuucc gcgacuggcc cgagcuccag gacgacaucc cccacauccu cgcccaggcc      840

cgcaagaucc ucuucgucau cgacggcuuc gacgagcucg gcgccgcccc cggcgcccuc      900

aucgaggaca ucugcggcga cugggagaag aagaagcccg uccccguccu ccucggcucc      960

cuccucaacc gcgucaugcu ccccaaggcc gcccuccucg ucaccacccg cccccgcgcc     1020

cuccgcgacc uccgcauccu cgccgaggag cccaucuaca uccgcgucga gggcuuccuc     1080

gaggaggacc gccgcgccua cuuccuccgc cacuucggcg acgaggacca ggccaugcgc     1140

gccuucgagc ucaugcgcuc caacgccgcc cucuuccagc ucggcuccgc ccccgccguc     1200

ugcuggaucg ucugcaccac ccucaagcuc cagauggaga agggcgagga ccccgucccc     1260

accugccuca cccgcaccgg ccucuuccuc cgcuuccucu gcucccgcuu cccccagggc     1320

gcccagcucc gcggcgcccu ccgcacccuc ucccuccucg ccgcccaggg ccucugggcc     1380

cagaccuccg uccuccaccg cgaggaccuc gagcgccucg gcguccagga guccgaccuc     1440

cgccucuucc ucgacggcga cauccuccgc caggaccgcg ucuccaaggg cugcuacucc     1500

uucauccacc ucuccuucca gcaguuccuc accgcccucu ucuacacccu cgagaaggag     1560

gaggaggagg accgcgacgg ccacaccugg gacaucggcg acguccagaa gcuccucucc     1620

ggcgucgagc gccuccgcaa ccccgaccuc auccaggccg gcuacuacuc cuucggccuc     1680

gccaacgaga agcgcgccaa ggagcucgag gccaccuucg gcugccgcau gucccccgac     1740

aucaagcagg agcuccuccg cugcgacauc uccugcaagg gcggccacuc caccgucacc     1800

gaccuccagg agcuccucgg cugccucuac gagucccagg aggaggagcu cgucaaggag     1860

gucauggccc aguucaagga gaucucccuc caccucaacg ccgucgacgu cguccccucc     1920

uccuucugcg ucaagcacug ccgcaaccuc cagaagaugu cccuccaggu caucaaggag     1980

aaccuccccg agaacgucac cgccuccgag uccgacgccg aggucgagcg cucccaggac     2040

gaccagcaca ugcuccccuu cuggaccgac cucugcucca ucuucggcuc caacaaggac     2100

cucaugggcc ucgccaucaa cgacuccuuc cucuccgccu cccucguccg cauccucugc     2160

gagcagaucg ccuccgacac cugccaccuc cagcgcgucg ucuucaagaa caucuccccc     2220

gccgacgccc accgcaaccu cugccucgcc cuccgcggcc acaagaccgu caccuaccuc     2280

acccuccagg gcaacgacca ggacgacaug uuccccgccc ucugcgaggu ccuccgccac     2340

cccgagugca accuccgcua ccucggccuc gucuccugcu ccgccaccac ccagcagugg     2400

gccgaccucu cccucgcccu cgaggucaac cagucccuca ccugcgucaa ccucuccgac     2460

aacgagcucc ucgacgaggg cgccaagcuc cucuacacca cccuccgcca ccccaagugc     2520

uuccuccagc gccucucccu cgagaacugc caccucaccg aggccaacug caaggaccuc     2580

gccgccgucc ucgucgucuc ccgcgagcuc acccaccucu gccucgccaa gaaccccauc     2640

ggcaacaccg gcgucaaguu ccucugcgag ggccuccgcu accccgagug caagcuccag     2700

acccucgucc ucuggaacug cgacaucacc uccgacggcu gcugcgaccu caccaagcuc     2760

cuccaggaga aguccucccu ccucugccuc gaccucggcc ucaaccacau cggcgucaag     2820

ggcaugaagu uccucugcga ggcccuccgc aagccccucu gcaaccuccg cugccucugg     2880

cucuggggcu gcuccauccc ccccuucucc ugcgaggacc ucugcuccgc ccucuccugc     2940

aaccaguccc ucgucacccu cgaccucggc cagaaccccc ucggcuccuc cggcgucaag     3000

augcucuucg agacccucac cugcuccucc ggcacccucc gcacccuccg ccucaagauc     3060

gacgacuuca acgacgagcu caacaagcuc cucgaggaga ucgaggagaa gaacccccag     3120

cucaucaucg acaccgagaa gcaccacccc ugggccgagc gccccuccuc ccacgacuuc     3180

augaucuga                                                             3189


<210>  9064
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP2__Homo_sapiens__AAG30289

<400>  9064
auggugagcu ccgcccagau gggcuucaac cugcaagcuc uccuugagca gcugucucag       60

gacgaauugu caaaguuuaa auacuuaauc accacauuca gucuggcaca cgagcuacag      120

aagauucccc auaaagaagu cgauaaggcc gacgggaaac aacucguuga gauacugacu      180

acgcacugcg auagcuauug gguggaaaug gcgucccuuc agguauuuga gaagaugcau      240

agaauggacc ugucugagag ggcuaaggau gaagugcggg aggccgcauu gaaaucguuc      300

aauaagcgca aaccucucuc acugggaauc acccgaaagg aacguccacc gcuggacguc      360

gaugagaugc ucgagagauu uaaaacagaa gcccaggcuu ucacugagac caaggguaac      420

gugauuuguu uaggcaagga aguuuuuaaa gggaagaaac ccgacaagga uaauaggugc      480

cgguacaucc ugaaaacaaa guuccgcgag auguggaaaa gcuggccugg agacaguaag      540

gaagugcagg ucauggcaga gagauauaag augcuuauuc cauuuuccaa ccccagggug      600

uugccuggcc cauucucuua caccguaguu cuguaugguc ccgccgggcu aggaaaaacu      660

acacucgcuc aaaagcugau gcuugauugg gccgaggaca aucugaucca caaauuuaag      720

uacgcguucu auuugagcug ucgggaacuc ucccgccugg gcccuugcuc auuugcagag      780

uuaguguucc gagauuggcc agaacugcag gacgacauac cgcauauccu cgcccaggcu      840

agaaaaauuc uuuucgucau cgauggcuuu gacgagcugg gggccgcacc cggagcuuug      900

auugaagaua ucugugguga cugggagaag aagaaaccug ugccagugcu acugggcagu      960

cuccugaaca gggucaugcu ucccaaggcc gcgcuguugg uuaccacgcg gccucgugcc     1020

cuccgcgauc ugagaauauu agcagaggaa ccaauuuaca ucagggugga gggguuccug     1080

gaagaggacc ggcgagcuua cuuucuacgc cacuucggag augaagacca ggccaugaga     1140

gcuuuugagc ucaugaggag caaugccgca cuguuccaac uuggcucugc ccccgcugua     1200

ugcuggauug uguguacuac cuugaaacug cagauggaga agggugaaga uccggucccu     1260

acaugccuca cucggaccgg gcuguuucuu cgcuuccugu guuccagauu uccccaggga     1320

gcgcaauuga ggggcgcacu ccguacacug ucauuacugg ccgcucaggg ccuaugggcc     1380

cagaccagcg ugcuccaccg ggaggaccug gaacgacuug ggguucagga gagugauuug     1440

agacuguucc ucgacggaga cauccugagg caagaucgcg ugucuaaagg uugcuauucc     1500

uuuauccauc ugagcuucca gcaguuuuua acggcacuuu ucuacacuuu ggagaaggaa     1560

gaggaagagg accgggaugg ccacacaugg gacauugggg auguccagaa gcuccugucg     1620

ggaguggaaa gacuaaggaa cccagaccug auacaagccg gcuauuacuc uuucggucuc     1680

gcuaaugaga aacgcgccaa ggagcuggaa gcaaccuuug ggugucgaau guccccugau     1740

aucaaacagg agcuuuugcg gugcgacauu ucaugcaagg gcggacauag uacuguaaca     1800

gaucugcagg aauuacucgg cugucuguau gagagccagg aagaggagcu uguuaaagaa     1860

gugauggcgc aauucaagga gaucucccug cacuugaacg cugucgacgu gguccccucu     1920

agcuuuugcg ugaagcacug ucguaaucuc cagaaaaugu cacugcaggu uauaaaggaa     1980

aaccuaccag agaaugugac cgccagugaa uccgaugcag agguagagag aagccaggac     2040

gaucaacaua ugcugcccuu cuggacggac cucugcucua uuuuuggguc aaacaaagac     2100

cugaugggac uugccaucaa ugauaguuuc uugagcgcuu cccuggucag gaucuuaugu     2160

gaacagauug ccucugauac cugccaccuc cagcgcgugg uuuuuaagaa caucucgccu     2220

gcagacgcuc aucggaaccu gugucuugcc cugagagguc acaaaacagu gacuuaccua     2280

acccuccaag gcaaugacca ggaugacaug uucccagcgc ugugcgaggu cuugaggcau     2340

ccggaaugua accugcgaua uuuagggcuc gugagcugcu ccgccacaac ucagcagugg     2400

gcugaucugu cacuugcacu ggagguaaau caaaguuuga ccugugugaa ccucucugac     2460

aaugagcugc uagaugaagg agccaagcug cuuuacacaa cccuccgcca ccccaaaugc     2520

uuucugcagc gguugagccu ggagaacugc cacuuaacug aagcuaauug uaaggaccuc     2580

gccgcaguuc uggucguguc cagagagcuu acgcaucugu gcuuggcgaa gaacccuauu     2640

ggcaauacag gugugaaauu ccucugugaa gggcugaggu acccagagug caagcuacag     2700

acccuggucc uuuggaacug ugauauaacu ucagacggcu gcugugaucu caccaaacug     2760

uugcaggaaa agagcucuuu acugugccuc gaccugggac uuaaucacau cggcguuaaa     2820

gggaugaagu uucuguguga ggccuugcgu aagccccuau gcaaccugcg cugucucugg     2880

cuguggggau gcuccauucc uccauucagu ugcgaggacc uuuguagcgc uuuaucuugc     2940

aaucaauccc uggugacacu cgauuugggu cagaaccccc ugggcucaag uggggugaaa     3000

augcucuuug aaacccugac uuguagcucg ggaacacuuc ggacgcugag auugaagauc     3060

gacgauuuca augacgagcu aaacaaacug cucgaagaga ucgaggaaaa gaacccgcag     3120

uuaauuauag auaccgagaa acaucacccu ugggccgaaa ggccauccuc ucacgacuuc     3180

augaucuga                                                             3189


<210>  9065
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP2__Homo_sapiens__AAG30289

<400>  9065
auggugagca gcgcccagau gggcuucaac cugcaggccc ugcuggagca gcugagccag       60

gacgagcuga gcaaguucaa guaccugauc accaccuuca gccuggccca cgagcugcag      120

aagauccccc acaaggaggu ggacaaggcc gacggcaagc agcuggugga gauccugacc      180

acccacugcg acagcuacug gguggagaug gccagccugc agguguucga gaagaugcac      240

agaauggacc ugagcgagag agccaaggac gaggugagag aggccgcccu gaagagcuuc      300

aacaagagaa agccccugag ccugggcauc accagaaagg agagaccccc ccuggacgug      360

gacgagaugc uggagagauu caagaccgag gcccaggccu ucaccgagac caagggcaac      420

gugaucugcc ugggcaagga gguguucaag ggcaagaagc ccgacaagga caacagaugc      480

agauacaucc ugaagaccaa guucagagag auguggaaga gcuggcccgg cgacagcaag      540

gaggugcagg ugauggccga gagauacaag augcugaucc ccuucagcaa ccccagagug      600

cugcccggcc ccuucagcua caccguggug cuguacggcc ccgccggccu gggcaagacc      660

acccuggccc agaagcugau gcuggacugg gccgaggaca accugaucca caaguucaag      720

uacgccuucu accugagcug cagagagcug agcagacugg gccccugcag cuucgccgag      780

cugguguuca gagacuggcc cgagcugcag gacgacaucc cccacauccu ggcccaggcc      840

agaaagaucc uguucgugau cgacggcuuc gacgagcugg gcgccgcccc cggcgcccug      900

aucgaggaca ucugcggcga cugggagaag aagaagcccg ugcccgugcu gcugggcagc      960

cugcugaaca gagugaugcu gcccaaggcc gcccugcugg ugaccaccag acccagagcc     1020

cugagagacc ugagaauccu ggccgaggag cccaucuaca ucagagugga gggcuuccug     1080

gaggaggaca gaagagccua cuuccugaga cacuucggcg acgaggacca ggccaugaga     1140

gccuucgagc ugaugagaag caacgccgcc cuguuccagc ugggcagcgc ccccgccgug     1200

ugcuggaucg ugugcaccac ccugaagcug cagauggaga agggcgagga ccccgugccc     1260

accugccuga ccagaaccgg ccuguuccug agauuccugu gcagcagauu cccccagggc     1320

gcccagcuga gaggcgcccu gagaacccug agccugcugg ccgcccaggg ccugugggcc     1380

cagaccagcg ugcugcacag agaggaccug gagagacugg gcgugcagga gagcgaccug     1440

agacuguucc uggacggcga cauccugaga caggacagag ugagcaaggg cugcuacagc     1500

uucauccacc ugagcuucca gcaguuccug accgcccugu ucuacacccu ggagaaggag     1560

gaggaggagg acagagacgg ccacaccugg gacaucggcg acgugcagaa gcugcugagc     1620

ggcguggaga gacugagaaa ccccgaccug auccaggccg gcuacuacag cuucggccug     1680

gccaacgaga agagagccaa ggagcuggag gccaccuucg gcugcagaau gagccccgac     1740

aucaagcagg agcugcugag augcgacauc agcugcaagg gcggccacag caccgugacc     1800

gaccugcagg agcugcuggg cugccuguac gagagccagg aggaggagcu ggugaaggag     1860

gugauggccc aguucaagga gaucagccug caccugaacg ccguggacgu ggugcccagc     1920

agcuucugcg ugaagcacug cagaaaccug cagaagauga gccugcaggu gaucaaggag     1980

aaccugcccg agaacgugac cgccagcgag agcgacgccg agguggagag aagccaggac     2040

gaccagcaca ugcugcccuu cuggaccgac cugugcagca ucuucggcag caacaaggac     2100

cugaugggcc uggccaucaa cgacagcuuc cugagcgcca gccuggugag aauccugugc     2160

gagcagaucg ccagcgacac cugccaccug cagagagugg uguucaagaa caucagcccc     2220

gccgacgccc acagaaaccu gugccuggcc cugagaggcc acaagaccgu gaccuaccug     2280

acccugcagg gcaacgacca ggacgacaug uuccccgccc ugugcgaggu gcugagacac     2340

cccgagugca accugagaua ccugggccug gugagcugca gcgccaccac ccagcagugg     2400

gccgaccuga gccuggcccu ggaggugaac cagagccuga ccugcgugaa ccugagcgac     2460

aacgagcugc uggacgaggg cgccaagcug cuguacacca cccugagaca ccccaagugc     2520

uuccugcaga gacugagccu ggagaacugc caccugaccg aggccaacug caaggaccug     2580

gccgccgugc ugguggugag cagagagcug acccaccugu gccuggccaa gaaccccauc     2640

ggcaacaccg gcgugaaguu ccugugcgag ggccugagau accccgagug caagcugcag     2700

acccuggugc uguggaacug cgacaucacc agcgacggcu gcugcgaccu gaccaagcug     2760

cugcaggaga agagcagccu gcugugccug gaccugggcc ugaaccacau cggcgugaag     2820

ggcaugaagu uccugugcga ggcccugaga aagccccugu gcaaccugag augccugugg     2880

cuguggggcu gcagcauccc ccccuucagc ugcgaggacc ugugcagcgc ccugagcugc     2940

aaccagagcc uggugacccu ggaccugggc cagaaccccc ugggcagcag cggcgugaag     3000

augcuguucg agacccugac cugcagcagc ggcacccuga gaacccugag acugaagauc     3060

gacgacuuca acgacgagcu gaacaagcug cuggaggaga ucgaggagaa gaacccccag     3120

cugaucaucg acaccgagaa gcaccacccc ugggccgaga gacccagcag ccacgacuuc     3180

augaucuga                                                             3189


<210>  9066
<211>  3189
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP2__Homo_sapiens__AAG30289

<400>  9066
auggugagcu ccgcccagau gggcuucaac cugcaagcuc uccuggagca gcuuucucag       60

gacgaacuga gcaaguuuaa auaccucauc accacauucu cccuggccca cgagcuucag      120

aagauucccc auaaagaagu cgauaaggcg gacgggaaac aacugguuga gauccucacg      180

acccacugcg auucuuauug gguggaaaug gcuagccuuc agguguuuga gaagaugcau      240

agaauggacc uguccgagcg ggccaaggau gaaguccgcg aggccgcucu caaaucuuuc      300

aauaagagaa aaccucugag ccuuggaauu acacggaagg aacgcccgcc ccuggacgug      360

gaugagaugc ucgagagauu uaaaaccgaa gcccaggcuu ucacagagac caagggcaac      420

guuaucuguc uggggaagga aguguuuaaa ggaaagaaac cugacaagga uaaucggugc      480

cgcuacauuc uuaaaacaaa guucagagag auguggaaau ccuggcccgg cgacagcaag      540

gaaguccagg ugauggccga gcgguauaag augcugaucc cuuuuucuaa cccccgcguu      600

cucccugggc cguucuccua caccgugguc cuguauggac ccgcgggccu gggcaaaacg      660

acccucgccc aaaagcugau gcuugauugg gcugaggaca aucugaucca caaauuuaag      720

uacgccuucu aucucagcug uagagaacug ucucggcuug ggccuugcuc cuuugcugag      780

cugguguucc gcgauuggcc cgaacuccag gacgacauuc cucauauccu ggcccaggcg      840

agaaaaauuc uguucgugau cgauggauuu gacgagcucg gcgccgcucc cggggcccug      900

auugaagaua ucuguggaga cugggagaag aagaaaccgg ucccuguucu ucugggcagc      960

cuccugaacc gggugaugcu ucccaaggcu gcccugcucg ugacaacccg cccuagagcc     1020

cugcgggauc ugcggauucu cgcugaggaa cccaucuaca uccgcgucga gggguuccug     1080

gaagaggacc ggagagcgua cuuucuucgc cacuucggag augaagacca ggccaugcgg     1140

gcuuuugagc ugaugagauc uaaugccgcc cucuuccaac ugggcuccgc ucccgccgug     1200

ugcuggauug uuuguacaac ccugaaacuu cagauggaga agggcgaaga uccugugccg     1260

acgugccuca cacgcaccgg gcuguuucug cgguuccucu guagcagauu uccccaggga     1320

gcgcaacugc gcggcgcucu uagaacacug ucccuccugg ccgcccaggg gcugugggcu     1380

cagaccucug uccuucacag agaggaccuc gaacgccugg gagugcagga gagcgaucug     1440

agacucuucc uggacggcga cauccuuaga caagaucggg uuuccaaagg gugcuauagc     1500

uuuauucauc ugucuuucca gcaguuucuc accgcccugu ucuacacacu ggagaaggaa     1560

gaggaagagg accgcgaugg acacacgugg gacaucggcg augugcagaa gcugcucucc     1620

ggcgucgaaa gacugcggaa cccugaccug auucaagcug gguauuacag cuucggacuc     1680

gccaaugaga aaagagcgaa ggagcuggaa gccaccuuug gcugucgcau gucucccgau     1740

aucaaacagg agcuucugcg gugcgacauc agcugcaaag ggggacauuc cacagugacc     1800

gaucuccagg aacugcuggg cugucuuuau gagucucagg aagaggagcu cgucaaggaa     1860

gugauggcuc aauucaagga gauuagccug caccugaacg ccguugacgu ggucccuucc     1920

agcuuuugcg ugaagcacug uagaaaucuc cagaaaaugu cucugcaggu uaucaaggaa     1980

aaccuucccg agaaugugac agcuuccgaa agcgaugccg aggucgagcg cucucaggac     2040

gaucaacaua ugcugccguu cuggaccgac cucugcucca uuuuugggag caacaaagac     2100

cugaugggcc uggcgaucaa ugauuccuuc cuuucugcca gccuggugcg gauucucugu     2160

gaacagaucg cuuccgacac gugccaucug cagcgggugg uuuuuaagaa caucucuccu     2220

gccgaugcuc accgcaaccu cugucuggcc cuuagaggac acaaaacagu caccuaccug     2280

acccuccaag gcaaugacca ggaugacaug uuccccgccc ugugcgaggu gcugcggcau     2340

ccugaaugua accuucgcua ucuggggcuc gugagcugcu ccgcuacaac ccagcagugg     2400

gcggaucuga gccucgcccu ggaggucaau caaucucuua caugugugaa ccuguccgac     2460

aaugagcucc uggaugaagg agcuaagcug cuuuacacga cccugagaca ccccaaaugc     2520

uuucuccagc ggcugagccu cgagaacugc caccugacag aagccaauug uaaggaccuu     2580

gccgcuguuc ugguggucuc ucgcgagcug acccaucucu gccuggccaa gaacccuauu     2640

ggcaauacag gggugaaauu ccuuugugaa ggacugagau accccgagug caagcuccag     2700

acccugguuc ucuggaacug ugauaucacg uccgacggcu gcugugaucu gaccaaacuu     2760

cugcaggaaa agagcucucu gcucugccug gaccuugggc ugaaucacau uggcgugaaa     2820

ggaaugaagu uucucuguga ggcgcugcgg aagccgcucu gcaaccugcg cugucuuugg     2880

cuguggggcu gcagcauccc ucccuucucc ugcgaggacc uguguagcgc ucucucuugc     2940

aaucaauccc uggucacacu ugaucugggg cagaaccccc ucggaagcuc cggcgugaaa     3000

augcuguuug aaacccucac auguucuagc gggacccuga gaacgcuucg gcugaagauu     3060

gacgauuuca augacgagcu gaacaaacuc cuggaagaga ucgaggaaaa gaacccucag     3120

cuuauuaucg auacagagaa acaucacccg ugggccgaaa gacccuccuc ucacgacuuc     3180

augaucuga                                                             3189


<210>  9067
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP3__Homo_sapiens__Q96P20

<400>  9067

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His 
    770                 775                 780                 


Glu Cys Cys Phe Asp Ile Ser Leu Val Leu Ser Ser Asn Gln Lys Leu 
785                 790                 795                 800 


Val Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg 
                805                 810                 815     


Leu Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu 
            820                 825                 830         


Trp Leu Val Ser Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala 
        835                 840                 845             


Ser Val Leu Ser Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu 
    850                 855                 860                 


Asn Ala Leu Gly Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys 
865                 870                 875                 880 


Asn Pro Gln Cys Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu 
                885                 890                 895     


Thr Ser Val Cys Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln 
            900                 905                 910         


Asn Leu Thr His Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly 
        915                 920                 925             


Ile Lys Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln 
    930                 935                 940                 


Val Leu Glu Leu Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp 
945                 950                 955                 960 


Leu Ser Thr Leu Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu 
                965                 970                 975     


Gly Asn Asn Asp Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val 
            980                 985                 990         


Leu Lys Gln Gln Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met 
        995                 1000                1005            


Tyr Phe Asn Tyr Glu Thr Lys Ser Ala Leu Glu Thr Leu Gln Glu Glu 
    1010                1015                1020                


Lys Pro Glu Leu Thr Val Val Phe Glu Pro Ser Trp 
1025                1030                1035    


<210>  9068
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP3__Homo_sapiens__AAI43363

<400>  9068
augaagaugg caagcacccg cugcaagcug gccagguacc uggaggaccu ggaggaugug       60

gacuugaaga aauuuaagau gcacuuagag gacuauccuc cccagaaggg cugcaucccc      120

cucccgaggg gucagacaga gaaggcagac cauguggauc uagccacgcu aaugaucgac      180

uucaaugggg aggagaaggc gugggccaug gccgugugga ucuucgcugc gaucaacagg      240

agagaccuuu augagaaagc aaaaagagau gagccgaagu gggguucaga uaaugcacgu      300

guuucgaauc ccacugugau augccaggaa gacagcauug aagaggagug gauggguuua      360

cuggaguacc uuucgagaau cucuauuugu aaaaugaaga aagauuaccg uaagaaguac      420

agaaaguacg ugagaagcag auuccagugc auugaagaca ggaaugcccg ucugggugag      480

agugugagcc ucaacaaacg cuacacacga cugcgucuca ucaaggagca ccggagccag      540

caggagaggg agcaggagcu ucuggccauc ggcaagacca agacguguga gagccccgug      600

agucccauua agauggaguu gcuguuugac cccgaugaug agcauucuga gccugugcac      660

acuguggugu uccagggggc ggcagggauu gggaaaacaa uccuggccag gaagaugaug      720

uuggacuggg cgucggggac acucuaccaa gacagguuug acuaucuguu cuauauccac      780

ugucgggagg ugagccuugu gacacagagg agccuggggg accugaucau gagcugcugc      840

cccgacccaa acccacccau ccacaagauc gugagaaaac ccuccagaau ccucuuccuc      900

auggacggcu ucgaugagcu gcaaggugcc uuugacgagc acauaggacc gcucugcacu      960

gacuggcaga aggccgagcg gggagacauu cuccugagca gccucaucag aaagaagcug     1020

cuucccgagg ccucucugcu caucaccacg agaccugugg cccuggagaa acugcagcac     1080

uugcuggacc auccucggca uguggagauc cuggguuucu ccgaggccaa aaggaaagag     1140

uacuucuuca aguacuucuc ugaugaggcc caagccaggg cagccuucag ucugauucag     1200

gagaacgagg uccucuucac caugugcuuc aucccccugg ucugcuggau cgugugcacu     1260

ggacugaaac agcagaugga gaguggcaag agccuugccc agacauccaa gaccaccacc     1320

gcgguguacg ucuucuuccu uuccaguuug cugcagcccc ggggagggag ccaggagcac     1380

ggccucugcg cccaccucug ggggcucugc ucuuuggcug cagauggaau cuggaaccag     1440

aaaauccugu uugaggaguc cgaccucagg aaucauggac ugcagaaggc ggaugugucu     1500

gcuuuccuga ggaugaaccu guuccaaaag gaaguggacu gcgagaaguu cuacagcuuc     1560

auccacauga cuuuccagga guucuuugcc gccauguacu accugcugga agaggaaaag     1620

gaaggaagga cgaacguucc agggagucgu uugaagcuuc ccagccgaga cgugacaguc     1680

cuucuggaaa acuauggcaa auucgaaaag ggguauuuga uuuuuguugu acguuuccuc     1740

uuuggccugg uaaaccagga gaggaccucc uacuuggaga agaaauuaag uugcaagauc     1800

ucucagcaaa ucaggcugga gcugcugaaa uggauugaag ugaaagccaa agcuaaaaag     1860

cugcagaucc agcccagcca gcuggaauug uucuacuguu uguacgagau gcaggaggag     1920

gacuucgugc aaagggccau ggacuauuuc cccaagauug agaucaaucu cuccaccaga     1980

auggaccaca ugguuucuuc cuuuugcauu gagaacuguc aucgggugga gucacugucc     2040

cugggguuuc uccauaacau gcccaaggag gaagaggagg aggaaaagga aggccgacac     2100

cuugauaugg ugcagugugu ccucccaagc uccucucaug cugccuguuc ucauggauug     2160

gugaacagcc accucacuuc caguuuuugc cggggccucu uuucaguucu gagcaccagc     2220

cagagucuaa cugaauugga ccucagugac aauucucugg gggacccagg gaugagagug     2280

uugugugaaa cgcuccagca uccuggcugu aacauucgga gauugugguu ggggcgcugu     2340

ggccucucgc augagugcug cuucgacauc uccuuggucc ucagcagcaa ccagaagcug     2400

guggagcugg accugaguga caacgcccuc ggugacuucg gaaucagacu ucugugugug     2460

ggacugaagc accuguugug caaucugaag aagcucuggu uggucagcug cugccucaca     2520

ucagcauguu gucaggaucu ugcaucagua uugagcacca gccauucccu gaccagacuc     2580

uauguggggg agaaugccuu gggagacuca ggagucgcaa uuuuauguga aaaagccaag     2640

aauccacagu guaaccugca gaaacugggg uuggugaauu cuggccuuac gucagucugu     2700

uguucagcuu uguccucggu acucagcacu aaucagaauc ucacgcaccu uuaccugcga     2760

ggcaacacuc ucggagacaa ggggaucaaa cuacucugug agggacucuu gcaccccgac     2820

ugcaagcuuc agguguugga auuagacaac ugcaaccuca cgucacacug cugcugggau     2880

cuuuccacac uucugaccuc cagccagagc cugcgaaagc ugagccuggg caacaaugac     2940

cugggcgacc ugggggucau gauguucugu gaagugcuga aacagcagag cugccuccug     3000

cagaaccugg gguugucuga aauguauuuc aauuaugaga caaaaagugc guuagaaaca     3060

cuucaagaag aaaagccuga gcugaccguc gucuuugagc cuucuuggua g              3111


<210>  9069
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP3__Homo_sapiens__AAI43363

<400>  9069
augaagaugg ccagcacccg cugcaagcug gcccgguacc ucgaggaccu ggaggacgug       60

gaccugaaga aguucaagau gcaccucgag gacuacccgc cccagaaggg cugcaucccc      120

cugccccgcg ggcagaccga gaaggcggac cacgucgacc uggccacgcu caugaucgac      180

uucaacggcg aggagaaggc cugggccaug gccgugugga ucuucgcggc caucaaccgg      240

cgcgaccugu acgagaaggc caagcgggac gagcccaagu ggggguccga caacgcccgc      300

gugagcaacc cgaccgucau cugccaggag gacuccaucg aggaggagug gaugggccug      360

cucgaguacc ugagccggau cuccaucugc aagaugaaga aggacuaccg caagaaguac      420

cggaaguacg ugcgcagccg guuccagugc aucgaggacc gcaacgcgcg gcugggggag      480

uccgugagcc ucaacaagcg cuacacccgg cugcgccuga ucaaggagca ccggucccag      540

caggagcgcg agcaggagcu ccuggccauc ggcaagacca agacgugcga gagccccguc      600

ucccccauca agauggagcu gcuguucgac cccgacgacg agcacagcga gccggugcac      660

accguggucu uccagggcgc cgccgggauc ggcaagacca uccuggcccg gaagaugaug      720

cuggacuggg cguccgggac ccucuaccag gaccgcuucg acuaccuguu cuacauccac      780

ugccgggagg ugagccuggu gacgcagcgc ucccucggcg accugaucau gagcugcugc      840

cccgacccca acccgcccau ccacaagauc guccgcaagc ccucccggau ccuguuccuc      900

auggacgggu ucgacgagcu gcagggcgcc uucgacgagc acaucggccc ccugugcacc      960

gacuggcaga aggccgagcg cggggacauc cuccugagcu cccugauccg gaagaagcuc     1020

cugcccgagg ccagccugcu caucaccacc cgcccggugg cccuggagaa gcugcagcac     1080

cuccuggacc acccccggca cguggagauc cugggcuuca gcgaggcgaa gcgcaaggag     1140

uacuucuuca aguacuucuc cgacgaggcc caggcccggg ccgccuucag ccucauccag     1200

gagaacgagg uccuguucac gaugugcuuc aucccccugg ugugcuggau cgugugcacc     1260

gggcucaagc agcagaugga guccggcaag agccuggcgc agaccuccaa gaccacgacc     1320

gccgucuacg uguucuuccu gagcucccuc cugcagcccc gcggcgggag ccaggagcac     1380

ggccugugcg cccaccugug ggggcucugc ucccuggccg ccgacggcau cuggaaccag     1440

aagauccugu ucgaggagag cgaccuccgg aaccacgggc ugcagaaggc ggacgugucc     1500

gccuuccugc gcaugaaccu cuuccagaag gaggucgacu gcgagaaguu cuacagcuuc     1560

auccacauga ccuuccagga guucuucgcc gccauguacu accugcugga ggaggagaag     1620

gagggccgga ccaacgugcc gggcucccgc cucaagcugc ccagccggga cgugacgguc     1680

cugcucgaga acuacgggaa guucgagaag ggcuaccuga ucuucguggu ccgcuuccug     1740

uucgggcucg ugaaccagga gcggaccucc uaccuggaga agaagcugag cugcaagauc     1800

ucccagcaga uccgccucga gcugcugaag uggaucgagg ugaaggcgaa ggccaagaag     1860

cuccagaucc agcccagcca gcuggagcug uucuacugcc ucuacgagau gcaggaggag     1920

gacuucgucc agcgggccau ggacuacuuc cccaagaucg agaucaaccu guccacccgc     1980

auggaccaca uggugagcag cuucugcauc gagaacugcc accgggugga gucccugagc     2040

cucggcuucc ugcacaacau gccgaaggag gaggaggagg aggagaagga ggggcgccac     2100

cuggacaugg uccagugcgu gcuccccucc agcucccacg ccgccugcag ccacggccug     2160

gugaacuccc accugaccag cuccuucugc cgcggccucu ucagcguccu guccacgagc     2220

cagucccuga ccgagcucga ccugagcgac aacucccugg gggaccccgg caugcgggug     2280

cucugcgaga cccugcagca ccccgggugc aacauccgcc ggcuguggcu cggccgcugc     2340

gggcugagcc acgagugcug cuucgacauc ucccuggugc ucagcagcaa ccagaagcug     2400

gucgagcugg accucuccga caacgcgcug ggcgacuucg gcauccggcu gcucugcgug     2460

gggcugaagc accuccucug caaccugaag aagcuguggc ucgugagcug cugccugacc     2520

uccgccugcu gccaggaccu ggccagcguc cucuccacga gccacucccu gacccgccug     2580

uacgugggcg agaacgcccu cggggacagc ggcguggcca uccugugcga gaaggcgaag     2640

aacccgcagu gcaaccugca gaagcucggc cuggucaacu ccgggcugac cagcgugugc     2700

ugcuccgccc ucagcuccgu gcugagcacc aaccagaacc ugacgcaccu cuaccugcgg     2760

ggcaacaccc ugggggacaa gggcaucaag cuccugugcg aggggcugcu ccaccccgac     2820

ugcaagcugc agguccugga gcucgacaac ugcaaccuga ccucccacug cugcugggac     2880

cugagcaccc uccugacguc cagccagucc cugcgcaagc ucagccuggg caacaacgac     2940

cugggcgacc ucggggugau gauguucugc gaggugcuga agcagcagag cugccugcuc     3000

cagaaccugg gccuguccga gauguacuuc aacuacgaga ccaagagcgc ccuggagacc     3060

cuccaggagg agaagcccga gcugaccguc guguucgagc cguccuggug a              3111


<210>  9070
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP3__Homo_sapiens__AAI43363

<400>  9070
augaagaugg ccuccacccg cugcaagcuc gcccgcuacc ucgaggaccu cgaggacguc       60

gaccucaaga aguucaagau gcaccucgag gacuaccccc cccagaaggg cugcaucccc      120

cucccccgcg gccagaccga gaaggccgac cacgucgacc ucgccacccu caugaucgac      180

uucaacggcg aggagaaggc cugggccaug gccgucugga ucuucgccgc caucaaccgc      240

cgcgaccucu acgagaaggc caagcgcgac gagcccaagu ggggcuccga caacgcccgc      300

gucuccaacc ccaccgucau cugccaggag gacuccaucg aggaggagug gaugggccuc      360

cucgaguacc ucucccgcau cuccaucugc aagaugaaga aggacuaccg caagaaguac      420

cgcaaguacg uccgcucccg cuuccagugc aucgaggacc gcaacgcccg ccucggcgag      480

uccgucuccc ucaacaagcg cuacacccgc cuccgccuca ucaaggagca ccgcucccag      540

caggagcgcg agcaggagcu ccucgccauc ggcaagacca agaccugcga gucccccguc      600

ucccccauca agauggagcu ccucuucgac cccgacgacg agcacuccga gcccguccac      660

accgucgucu uccagggcgc cgccggcauc ggcaagacca uccucgcccg caagaugaug      720

cucgacuggg ccuccggcac ccucuaccag gaccgcuucg acuaccucuu cuacauccac      780

ugccgcgagg ucucccucgu cacccagcgc ucccucggcg accucaucau guccugcugc      840

cccgacccca acccccccau ccacaagauc guccgcaagc ccucccgcau ccucuuccuc      900

auggacggcu ucgacgagcu ccagggcgcc uucgacgagc acaucggccc ccucugcacc      960

gacuggcaga aggccgagcg cggcgacauc cuccucuccu cccucauccg caagaagcuc     1020

cuccccgagg ccucccuccu caucaccacc cgccccgucg cccucgagaa gcuccagcac     1080

cuccucgacc acccccgcca cgucgagauc cucggcuucu ccgaggccaa gcgcaaggag     1140

uacuucuuca aguacuucuc cgacgaggcc caggcccgcg ccgccuucuc ccucauccag     1200

gagaacgagg uccucuucac caugugcuuc aucccccucg ucugcuggau cgucugcacc     1260

ggccucaagc agcagaugga guccggcaag ucccucgccc agaccuccaa gaccaccacc     1320

gccgucuacg ucuucuuccu cuccucccuc cuccagcccc gcggcggcuc ccaggagcac     1380

ggccucugcg cccaccucug gggccucugc ucccucgccg ccgacggcau cuggaaccag     1440

aagauccucu ucgaggaguc cgaccuccgc aaccacggcc uccagaaggc cgacgucucc     1500

gccuuccucc gcaugaaccu cuuccagaag gaggucgacu gcgagaaguu cuacuccuuc     1560

auccacauga ccuuccagga guucuucgcc gccauguacu accuccucga ggaggagaag     1620

gagggccgca ccaacguccc cggcucccgc cucaagcucc ccucccgcga cgucaccguc     1680

cuccucgaga acuacggcaa guucgagaag ggcuaccuca ucuucgucgu ccgcuuccuc     1740

uucggccucg ucaaccagga gcgcaccucc uaccucgaga agaagcucuc cugcaagauc     1800

ucccagcaga uccgccucga gcuccucaag uggaucgagg ucaaggccaa ggccaagaag     1860

cuccagaucc agcccuccca gcucgagcuc uucuacugcc ucuacgagau gcaggaggag     1920

gacuucgucc agcgcgccau ggacuacuuc cccaagaucg agaucaaccu cuccacccgc     1980

auggaccaca uggucuccuc cuucugcauc gagaacugcc accgcgucga gucccucucc     2040

cucggcuucc uccacaacau gcccaaggag gaggaggagg aggagaagga gggccgccac     2100

cucgacaugg uccagugcgu ccuccccucc uccucccacg ccgccugcuc ccacggccuc     2160

gucaacuccc accucaccuc cuccuucugc cgcggccucu ucuccguccu cuccaccucc     2220

cagucccuca ccgagcucga ccucuccgac aacucccucg gcgaccccgg caugcgcguc     2280

cucugcgaga cccuccagca ccccggcugc aacauccgcc gccucuggcu cggccgcugc     2340

ggccucuccc acgagugcug cuucgacauc ucccucgucc ucuccuccaa ccagaagcuc     2400

gucgagcucg accucuccga caacgcccuc ggcgacuucg gcauccgccu ccucugcguc     2460

ggccucaagc accuccucug caaccucaag aagcucuggc ucgucuccug cugccucacc     2520

uccgccugcu gccaggaccu cgccuccguc cucuccaccu cccacucccu cacccgccuc     2580

uacgucggcg agaacgcccu cggcgacucc ggcgucgcca uccucugcga gaaggccaag     2640

aacccccagu gcaaccucca gaagcucggc cucgucaacu ccggccucac cuccgucugc     2700

ugcuccgccc ucuccuccgu ccucuccacc aaccagaacc ucacccaccu cuaccuccgc     2760

ggcaacaccc ucggcgacaa gggcaucaag cuccucugcg agggccuccu ccaccccgac     2820

ugcaagcucc agguccucga gcucgacaac ugcaaccuca ccucccacug cugcugggac     2880

cucuccaccc uccucaccuc cucccagucc cuccgcaagc ucucccucgg caacaacgac     2940

cucggcgacc ucggcgucau gauguucugc gagguccuca agcagcaguc cugccuccuc     3000

cagaaccucg gccucuccga gauguacuuc aacuacgaga ccaaguccgc ccucgagacc     3060

cuccaggagg agaagcccga gcucaccguc gucuucgagc ccuccuggug a              3111


<210>  9071
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP3__Homo_sapiens__AAI43363

<400>  9071
augaagaugg ccagcaccag augcaaacug gcuagguacc ucgaggaccu ugaagaugug       60

gaccugaaga aauucaagau gcacuuggag gauuaucccc cucagaaagg cuguauccca      120

uuaccgcggg ggcaaacaga aaaggcagac caugucgauc uggccacucu aaugauugac      180

uuuaacggag aggaaaaggc gugggcuaug gccguuugga uauucgcagc caucaaucgc      240

cgagaucucu acgagaaagc uaagcgugac gagcccaaau gggguuccga uaacgcaaga      300

gugucuaauc cuacgguaau uugccaggaa gacucaaucg aggaagagug gaugggccug      360

cuugaguauc ugaguaggau uagcaucugu aagaugaaaa aggauuaccg gaagaaauau      420

cgcaaguacg ugagauccag guuucagugc auagaagacc ggaacgcccg cuugggggag      480

ucugucucgc ucaauaaacg auauaccaga cugaggcuga ucaaggaaca ccggucacag      540

caagagcgug aacaggagcu cuuagcuauu ggaaaaacaa agacuuguga gagcccagug      600

agucccauca aaauggaacu gcuuuucgau ccugacgacg agcauuccga accaguucac      660

accguggucu uucagggcgc cgcggguauu gggaagacaa ucuuggcacg caagaugaug      720

cuggauuggg ccucuggaac ccuauaccag gacagauucg auuaccucuu uuauauacau      780

ugcagggagg ugagccuggu aacucaacgg ucccuuggcg accugauuau gucauguugc      840

cccgauccua acccaccgau ccacaaaauu guucgaaagc ccagucgcau cuuguuccuc      900

auggacggcu uugaugaacu gcagggggcu uucgacgagc acaucggacc uuuauguaca      960

gauuggcaga aagccgagag aggugacauu cugcucagcu cucuuauaag gaagaaacug     1020

uugccagaag caucccuacu gaucaccacg cggcccgugg cucucgagaa gcugcagcau     1080

cuucuggauc acccucgcca ugucgaaauu uugggcuuuu cagaggccaa gagaaaagaa     1140

uacuucuuua aguauuucag cgacgaggcg caagccaggg cagcuuucag ucucauccag     1200

gagaaugaag ugcuguuuac uaugugcuuc auaccauuag uguguuggau ugucugcacc     1260

gggcugaaac agcaaaugga gucuggaaag ucccuagccc agacaagcaa aacuaccaca     1320

gcuguuuacg uguuuuuccu cucgucucug cuucagcccc guggcgguuc ccaggaacac     1380

ggguugugcg cccaccugug gggacucugu ucacuggcag ccgacggcau cuggaaccaa     1440

aagauccuuu uugaggagag ugaucugcgg aaucauggcu ugcagaaggc ugacguaagc     1500

gcguuccucc gaaugaaccu guuucagaaa gaaguggauu gcgagaaguu cuauuccuuu     1560

auucacauga ccuuccagga auuuuucgca gccauguacu auuuacugga ggaagagaaa     1620

gaggggagaa cgaauguccc gggaucuagg cuaaagcucc cuagccgcga cgugacuguu     1680

cugcuugaaa acuacgguaa auuugagaag ggcuacuuga ucuucguggu ccgguuccug     1740

uuugggcucg ugaaucaaga aagaacauca uaucuggaga agaaauuaag uuguaagauu     1800

ucccagcaga uaaggcugga acuuuugaaa uggaucgagg uaaaggcuaa agccaagaaa     1860

cuccagauuc aacccagcca gcuggagcua uucuacugcc uguaugaaau gcaggaggaa     1920

gauuuuguuc agcgcgcaau ggacuacuuc ccaaagaucg agaucaaccu cucuacccga     1980

auggaucaua uggugucaag uuuuuguauu gaaaauugcc accgggucga gagccugucc     2040

cuuggauucu ugcauaacau gccuaaggag gaagaggaag aggagaaaga aggccgucac     2100

cuggacaugg ugcaaugugu cuuacccucu ucgagccacg ccgcuugcuc ccauggucuc     2160

gugaacucac accugacaag uucuuuuugu agagggcuuu ucagcguucu guccacuuca     2220

cagagcuuga ccgagcucga ucugucugac aauucccuag gcgauccagg aaugagggug     2280

cugugcgaaa cgcuccagca ucccggcugu aacauacgcc ggcuguggcu ugggagaugc     2340

ggauugaguc acgagugcug uuuugacauc agccugguau uaucuuccaa ucaaaagcuc     2400

gucgaacugg aucuuucaga caacgcccug ggugacuucg gcauuaggcu acucugcgug     2460

gggcugaaac acuugcugug uaauuuaaag aaacucuggc ugguuaguug cugucuuacc     2520

agcgcaugcu gucaggaucu ggcgucggug uuguccacau cucauagccu cacucgacug     2580

uaugucggag agaacgcucu aggcgacuca gguguggcca uccugugcga gaaggcaaag     2640

aauccucagu guaaccuuca gaaacucggg cugguaaaua guggcuugac cuccgugugc     2700

uguucugccc ugagcuccgu uuuaucaaca aaccaaaauc ucacucaccu guaccuucgc     2760

ggaaacaccc ugggcgauaa ggggauuaaa uugcucugcg aaggacugcu acauccagac     2820

ugcaagcugc agguccuuga gcucgauaau uguaaccuga caagccacug cuguugggac     2880

uugaguaccu uacugacuuc uucccagagc cuccggaaac ugucgcuugg uaauaacgau     2940

cugggcgacu ugggggugau gauguuuugc gaagugcuaa agcagcaauc augucugcuc     3000

cagaaccugg gacuuucuga gauguauuuc aauuacgaaa cgaagagugc uuuagagaca     3060

cugcaggagg aaaaaccgga gcucaccguc guuuuugaac ccuccuggug a              3111


<210>  9072
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP3__Homo_sapiens__AAI43363

<400>  9072
augaagaugg ccagcaccag augcaagcug gccagauacc uggaggaccu ggaggacgug       60

gaccugaaga aguucaagau gcaccuggag gacuaccccc cccagaaggg cugcaucccc      120

cugcccagag gccagaccga gaaggccgac cacguggacc uggccacccu gaugaucgac      180

uucaacggcg aggagaaggc cugggccaug gccgugugga ucuucgccgc caucaacaga      240

agagaccugu acgagaaggc caagagagac gagcccaagu ggggcagcga caacgccaga      300

gugagcaacc ccaccgugau cugccaggag gacagcaucg aggaggagug gaugggccug      360

cuggaguacc ugagcagaau cagcaucugc aagaugaaga aggacuacag aaagaaguac      420

agaaaguacg ugagaagcag auuccagugc aucgaggaca gaaacgccag acugggcgag      480

agcgugagcc ugaacaagag auacaccaga cugagacuga ucaaggagca cagaagccag      540

caggagagag agcaggagcu gcuggccauc ggcaagacca agaccugcga gagccccgug      600

agccccauca agauggagcu gcuguucgac cccgacgacg agcacagcga gcccgugcac      660

accguggugu uccagggcgc cgccggcauc ggcaagacca uccuggccag aaagaugaug      720

cuggacuggg ccagcggcac ccuguaccag gacagauucg acuaccuguu cuacauccac      780

ugcagagagg ugagccuggu gacccagaga agccugggcg accugaucau gagcugcugc      840

cccgacccca acccccccau ccacaagauc gugagaaagc ccagcagaau ccuguuccug      900

auggacggcu ucgacgagcu gcagggcgcc uucgacgagc acaucggccc ccugugcacc      960

gacuggcaga aggccgagag aggcgacauc cugcugagca gccugaucag aaagaagcug     1020

cugcccgagg ccagccugcu gaucaccacc agacccgugg cccuggagaa gcugcagcac     1080

cugcuggacc accccagaca cguggagauc cugggcuuca gcgaggccaa gagaaaggag     1140

uacuucuuca aguacuucag cgacgaggcc caggccagag ccgccuucag ccugauccag     1200

gagaacgagg ugcuguucac caugugcuuc aucccccugg ugugcuggau cgugugcacc     1260

ggccugaagc agcagaugga gagcggcaag agccuggccc agaccagcaa gaccaccacc     1320

gccguguacg uguucuuccu gagcagccug cugcagccca gaggcggcag ccaggagcac     1380

ggccugugcg cccaccugug gggccugugc agccuggccg ccgacggcau cuggaaccag     1440

aagauccugu ucgaggagag cgaccugaga aaccacggcc ugcagaaggc cgacgugagc     1500

gccuuccuga gaaugaaccu guuccagaag gagguggacu gcgagaaguu cuacagcuuc     1560

auccacauga ccuuccagga guucuucgcc gccauguacu accugcugga ggaggagaag     1620

gagggcagaa ccaacgugcc cggcagcaga cugaagcugc ccagcagaga cgugaccgug     1680

cugcuggaga acuacggcaa guucgagaag ggcuaccuga ucuucguggu gagauuccug     1740

uucggccugg ugaaccagga gagaaccagc uaccuggaga agaagcugag cugcaagauc     1800

agccagcaga ucagacugga gcugcugaag uggaucgagg ugaaggccaa ggccaagaag     1860

cugcagaucc agcccagcca gcuggagcug uucuacugcc uguacgagau gcaggaggag     1920

gacuucgugc agagagccau ggacuacuuc cccaagaucg agaucaaccu gagcaccaga     1980

auggaccaca uggugagcag cuucugcauc gagaacugcc acagagugga gagccugagc     2040

cugggcuucc ugcacaacau gcccaaggag gaggaggagg aggagaagga gggcagacac     2100

cuggacaugg ugcagugcgu gcugcccagc agcagccacg ccgccugcag ccacggccug     2160

gugaacagcc accugaccag cagcuucugc agaggccugu ucagcgugcu gagcaccagc     2220

cagagccuga ccgagcugga ccugagcgac aacagccugg gcgaccccgg caugagagug     2280

cugugcgaga cccugcagca ccccggcugc aacaucagaa gacuguggcu gggcagaugc     2340

ggccugagcc acgagugcug cuucgacauc agccuggugc ugagcagcaa ccagaagcug     2400

guggagcugg accugagcga caacgcccug ggcgacuucg gcaucagacu gcugugcgug     2460

ggccugaagc accugcugug caaccugaag aagcuguggc uggugagcug cugccugacc     2520

agcgccugcu gccaggaccu ggccagcgug cugagcacca gccacagccu gaccagacug     2580

uacgugggcg agaacgcccu gggcgacagc ggcguggcca uccugugcga gaaggccaag     2640

aacccccagu gcaaccugca gaagcugggc cuggugaaca gcggccugac cagcgugugc     2700

ugcagcgccc ugagcagcgu gcugagcacc aaccagaacc ugacccaccu guaccugaga     2760

ggcaacaccc ugggcgacaa gggcaucaag cugcugugcg agggccugcu gcaccccgac     2820

ugcaagcugc aggugcugga gcuggacaac ugcaaccuga ccagccacug cugcugggac     2880

cugagcaccc ugcugaccag cagccagagc cugagaaagc ugagccuggg caacaacgac     2940

cugggcgacc ugggcgugau gauguucugc gaggugcuga agcagcagag cugccugcug     3000

cagaaccugg gccugagcga gauguacuuc aacuacgaga ccaagagcgc ccuggagacc     3060

cugcaggagg agaagcccga gcugaccgug guguucgagc ccagcuggug a              3111


<210>  9073
<211>  3111
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP3__Homo_sapiens__AAI43363

<400>  9073
augaagaugg ccagcaccag augcaaacug gcucgguacc ucgaggaccu ggaagaugug       60

gaccuuaaga aauucaagau gcaccuggag gauuaucccc cucagaaagg cuguaucccg      120

cucccccgcg ggcaaacaga aaaggccgac caugucgauc uggcgacgcu uaugauugac      180

uuuaacggag aggaaaaggc uugggccaug gccguuugga ucuucgcugc cauuaauaga      240

cgggaucugu acgagaaagc uaagcgcgac gagccuaaau ggggcuccga uaacgccaga      300

gugucuaauc ccaccgugau cugccaggaa gacagcauug aggaagagug gauggggcuc      360

cuggaguauc ugucccggau cucuaucugu aagaugaaaa aggauuaccg caagaaauau      420

agaaaguacg uccggagccg cuuucagugc auugaagaca gaaacgcgcg gcucggagag      480

uccgugucuc ugaauaaacg cuauacaaga cuucggcuga ucaaggaaca ccgcagccag      540

caagagagag aacaggagcu ccuggccauu ggcaaaacca agacauguga guccccuguu      600

agccccauca aaauggaacu ucuguucgau ccugacgacg agcauucuga accggugcac      660

accgucgugu uucagggggc ugccggaauu ggcaagacaa uccucgcucg gaagaugaug      720

cuggauuggg ccuccggcac ccuguaccag gacagauucg auuaccucuu uuauauucau      780

ugccgcgagg uuagccuggu gacgcaacgg ucucuugggg accugaucau guccuguugc      840

cccgauccua aucccccuau ccacaaaauu gucagaaagc ccagccgcau ccucuuccug      900

auggacggau uugaugaacu ucagggcgcg uucgacgagc acauugggcc gcuguguacc      960

gauuggcaga aagccgagcg gggagacauc cuccugucuu cccugauuag aaagaaacuc     1020

cugccugaag cuagccuucu gaucacaacc cgccccgugg cccucgagaa gcugcagcau     1080

cuucuggauc acccucggca uguggaaauc cucggcuuuu ccgaggcuaa gagaaaagaa     1140

uacuucuuua aguauuucuc ugacgaggcc caagcccgcg cugcguucag ccugauucag     1200

gagaacgaag uccuguuuac aaugugcuuc aucccccucg uuuguuggau ugugugcacc     1260

gggcugaaac agcaaaugga guccggaaag agccuugccc agacgucuaa aacaaccaca     1320

gcuguguacg ucuuuuuccu guccagccuc cugcagcccc ggggcggcuc ucaggaacac     1380

gggcugugcg cccaccuuug gggacucugu agccuggccg cugacggcau cuggaaccaa     1440

aagauucugu uugaggaguc cgaucucaga aaucaugggc ugcagaaggc cgacgugucu     1500

gcguuccuuc gcaugaaccu guuucagaaa gaaguugauu gcgagaaguu cuauagcuuu     1560

auccacauga ccuuccagga auuuuucgcu gccauguacu aucuccugga ggaagagaaa     1620

gagggacgga ccaaugugcc uggcuccaga cugaagcugc cgagccggga cgucacagug     1680

cuccuggaaa acuacgggaa auuugagaag ggauaccuga ucuucguugu gcgcuuccuc     1740

uuuggccugg ucaaucaaga aagaacgucu uaucuugaga agaaacuguc cuguaagauu     1800

agccagcaga uccggcucga acugcugaaa uggauugagg ugaaggccaa agcuaagaaa     1860

cuucagaucc aacccucuca gcucgagcug uucuacugcc uguaugaaau gcaggaggaa     1920

gauuuugucc agagagccau ggacuacuuc ccuaagauug agaucaaccu cuccacccgc     1980

auggaucaua uggugagcuc cuuuuguauu gaaaauugcc accggguuga gucucugagc     2040

cuuggcuucc ugcauaacau gcccaaggag gaagaggaag aggagaaaga agggagacac     2100

cucgacaugg ugcaaugugu ccugccuucc ucuagccacg cugccugcuc ccauggacug     2160

gugaacagcc accuuacauc uuccuuuugu cgcggccucu ucagcguucu gucuaccucc     2220

cagagccuga cagagcucga ucugucugac aauagccuug gggaucccgg aaugagagug     2280

cugugcgaaa cccuccagca uccgggcugu aacauccggc gccuguggcu ggggagaugc     2340

ggccuuuccc acgagugcug uuuugacauc agccuggucc ucucuuccaa ucaaaagcug     2400

guggaacucg aucugagcga caacgcgcuu ggagacuucg gcauucggcu gcucugcgug     2460

gggcugaaac accuucuuug uaaucugaag aaacucuggc ugguuuccug cugucucacg     2520

ucugccugcu gucaggaucu ggcuagcguc cuuuccacau cucauagccu gacccgccuc     2580

uaugugggag agaacgcccu gggcgacucc gggguggcua uccugugcga gaaggccaag     2640

aauccucagu guaaccuuca gaaacuggga cucgucaauu cuggccugac cagcgugugc     2700

uguuccgcgc ucagcucugu ucuguccaca aaccaaaauc uuacccaccu guaccugaga     2760

gggaacacac ucggcgauaa gggaauuaaa cugcuuugcg aaggccugcu ccaucccgac     2820

ugcaagcucc aggugcugga gcuggauaau uguaaccuua cgagccacug cuguugggac     2880

cugucuaccc ugcucacauc cagccagucu cugcggaaac uuucccuggg gaauaacgau     2940

cucggagacc ugggcgucau gauguuuugc gaagugcuca agcagcaaag cugucugcuu     3000

cagaaccugg ggcuguccga gauguauuuc aauuacgaaa ccaagagcgc ccucgagaca     3060

cugcaggagg aaaaaccuga gcuuaccguu guguuugaac ccucuuggug a              3111


<210>  9074
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP4__Homo_sapiens__Q96MN2

<400>  9074

Met Ala Ala Ser Phe Phe Ser Asp Phe Gly Leu Met Trp Tyr Leu Glu 
1               5                   10                  15      


Glu Leu Lys Lys Glu Glu Phe Arg Lys Phe Lys Glu His Leu Lys Gln 
            20                  25                  30          


Met Thr Leu Gln Leu Glu Leu Lys Gln Ile Pro Trp Thr Glu Val Lys 
        35                  40                  45              


Lys Ala Ser Arg Glu Glu Leu Ala Asn Leu Leu Ile Lys His Tyr Glu 
    50                  55                  60                  


Glu Gln Gln Ala Trp Asn Ile Thr Leu Arg Ile Phe Gln Lys Met Asp 
65                  70                  75                  80  


Arg Lys Asp Leu Cys Met Lys Val Met Arg Glu Arg Thr Gly Tyr Thr 
                85                  90                  95      


Lys Thr Tyr Gln Ala His Ala Lys Gln Lys Phe Ser Arg Leu Trp Ser 
            100                 105                 110         


Ser Lys Ser Val Thr Glu Ile His Leu Tyr Phe Glu Glu Glu Val Lys 
        115                 120                 125             


Gln Glu Glu Cys Asp His Leu Asp Arg Leu Phe Ala Pro Lys Glu Ala 
    130                 135                 140                 


Gly Lys Gln Pro Arg Thr Val Ile Ile Gln Gly Pro Gln Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Thr Leu Leu Met Lys Leu Met Met Ala Trp Ser Asp Asn Lys 
                165                 170                 175     


Ile Phe Arg Asp Arg Phe Leu Tyr Thr Phe Tyr Phe Cys Cys Arg Glu 
            180                 185                 190         


Leu Arg Glu Leu Pro Pro Thr Ser Leu Ala Asp Leu Ile Ser Arg Glu 
        195                 200                 205             


Trp Pro Asp Pro Ala Ala Pro Ile Thr Glu Ile Val Ser Gln Pro Glu 
    210                 215                 220                 


Arg Leu Leu Phe Val Ile Asp Ser Phe Glu Glu Leu Gln Gly Gly Leu 
225                 230                 235                 240 


Asn Glu Pro Asp Ser Asp Leu Cys Gly Asp Leu Met Glu Lys Arg Pro 
                245                 250                 255     


Val Gln Val Leu Leu Ser Ser Leu Leu Arg Lys Lys Met Leu Pro Glu 
            260                 265                 270         


Ala Ser Leu Leu Ile Ala Ile Lys Pro Val Cys Pro Lys Glu Leu Arg 
        275                 280                 285             


Asp Gln Val Thr Ile Ser Glu Ile Tyr Gln Pro Arg Gly Phe Asn Glu 
    290                 295                 300                 


Ser Asp Arg Leu Val Tyr Phe Cys Cys Phe Phe Lys Asp Pro Lys Arg 
305                 310                 315                 320 


Ala Met Glu Ala Phe Asn Leu Val Arg Glu Ser Glu Gln Leu Phe Ser 
                325                 330                 335     


Ile Cys Gln Ile Pro Leu Leu Cys Trp Ile Leu Cys Thr Ser Leu Lys 
            340                 345                 350         


Gln Glu Met Gln Lys Gly Lys Asp Leu Ala Leu Thr Cys Gln Ser Thr 
        355                 360                 365             


Thr Ser Val Tyr Ser Ser Phe Val Phe Asn Leu Phe Thr Pro Glu Gly 
    370                 375                 380                 


Ala Glu Gly Pro Thr Pro Gln Thr Gln His Gln Leu Lys Ala Leu Cys 
385                 390                 395                 400 


Ser Leu Ala Ala Glu Gly Met Trp Thr Asp Thr Phe Glu Phe Cys Glu 
                405                 410                 415     


Asp Asp Leu Arg Arg Asn Gly Val Val Asp Ala Asp Ile Pro Ala Leu 
            420                 425                 430         


Leu Gly Thr Lys Ile Leu Leu Lys Tyr Gly Glu Arg Glu Ser Ser Tyr 
        435                 440                 445             


Val Phe Leu His Val Cys Ile Gln Glu Phe Cys Ala Ala Leu Phe Tyr 
    450                 455                 460                 


Leu Leu Lys Ser His Leu Asp His Pro His Pro Ala Val Arg Cys Val 
465                 470                 475                 480 


Gln Glu Leu Leu Val Ala Asn Phe Glu Lys Ala Arg Arg Ala His Trp 
                485                 490                 495     


Ile Phe Leu Gly Cys Phe Leu Thr Gly Leu Leu Asn Lys Lys Glu Gln 
            500                 505                 510         


Glu Lys Leu Asp Ala Phe Phe Gly Phe Gln Leu Ser Gln Glu Ile Lys 
        515                 520                 525             


Gln Gln Ile His Gln Cys Leu Lys Ser Leu Gly Glu Arg Gly Asn Pro 
    530                 535                 540                 


Gln Gly Gln Val Asp Ser Leu Ala Ile Phe Tyr Cys Leu Phe Glu Met 
545                 550                 555                 560 


Gln Asp Pro Ala Phe Val Lys Gln Ala Val Asn Leu Leu Gln Glu Ala 
                565                 570                 575     


Asn Phe His Ile Ile Asp Asn Val Asp Leu Val Val Ser Ala Tyr Cys 
            580                 585                 590         


Leu Lys Tyr Cys Ser Ser Leu Arg Lys Leu Cys Phe Ser Val Gln Asn 
        595                 600                 605             


Val Phe Lys Lys Glu Asp Glu His Ser Ser Thr Ser Asp Tyr Ser Leu 
    610                 615                 620                 


Ile Cys Trp His His Ile Cys Ser Val Leu Thr Thr Ser Gly His Leu 
625                 630                 635                 640 


Arg Glu Leu Gln Val Gln Asp Ser Thr Leu Ser Glu Ser Thr Phe Val 
                645                 650                 655     


Thr Trp Cys Asn Gln Leu Arg His Pro Ser Cys Arg Leu Gln Lys Leu 
            660                 665                 670         


Gly Ile Asn Asn Val Ser Phe Ser Gly Gln Ser Val Leu Leu Phe Glu 
        675                 680                 685             


Val Leu Phe Tyr Gln Pro Asp Leu Lys Tyr Leu Ser Phe Thr Leu Thr 
    690                 695                 700                 


Lys Leu Ser Arg Asp Asp Ile Arg Ser Leu Cys Asp Ala Leu Asn Tyr 
705                 710                 715                 720 


Pro Ala Gly Asn Val Lys Glu Leu Ala Leu Val Asn Cys His Leu Ser 
                725                 730                 735     


Pro Ile Asp Cys Glu Val Leu Ala Gly Leu Leu Thr Asn Asn Lys Lys 
            740                 745                 750         


Leu Thr Tyr Leu Asn Val Ser Cys Asn Gln Leu Asp Thr Gly Val Pro 
        755                 760                 765             


Leu Leu Cys Glu Ala Leu Cys Ser Pro Asp Thr Val Leu Val Tyr Leu 
    770                 775                 780                 


Met Leu Ala Phe Cys His Leu Ser Glu Gln Cys Cys Glu Tyr Ile Ser 
785                 790                 795                 800 


Glu Met Leu Leu Arg Asn Lys Ser Val Arg Tyr Leu Asp Leu Ser Ala 
                805                 810                 815     


Asn Val Leu Lys Asp Glu Gly Leu Lys Thr Leu Cys Glu Ala Leu Lys 
            820                 825                 830         


His Pro Asp Cys Cys Leu Asp Ser Leu Cys Leu Val Lys Cys Phe Ile 
        835                 840                 845             


Thr Ala Ala Gly Cys Glu Asp Leu Ala Ser Ala Leu Ile Ser Asn Gln 
    850                 855                 860                 


Asn Leu Lys Ile Leu Gln Ile Gly Cys Asn Glu Ile Gly Asp Val Gly 
865                 870                 875                 880 


Val Gln Leu Leu Cys Arg Ala Leu Thr His Thr Asp Cys Arg Leu Glu 
                885                 890                 895     


Ile Leu Gly Leu Glu Glu Cys Gly Leu Thr Ser Thr Cys Cys Lys Asp 
            900                 905                 910         


Leu Ala Ser Val Leu Thr Cys Ser Lys Thr Leu Gln Gln Leu Asn Leu 
        915                 920                 925             


Thr Leu Asn Thr Leu Asp His Thr Gly Val Val Val Leu Cys Glu Ala 
    930                 935                 940                 


Leu Arg His Pro Glu Cys Ala Leu Gln Val Leu Gly Leu Arg Lys Thr 
945                 950                 955                 960 


Asp Phe Asp Glu Glu Thr Gln Ala Leu Leu Thr Ala Glu Glu Glu Arg 
                965                 970                 975     


Asn Pro Asn Leu Thr Ile Thr Asp Asp Cys Asp Thr Ile Thr Arg Val 
            980                 985                 990         


Glu Ile 
        


<210>  9075
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP4__Homo_sapiens__CCDS12936.1

<400>  9075
auggcagccu cuuucuucuc ugauuuuggu cuuauguggu aucuggagga gcucaaaaag       60

gaggaguuca ggaaauuuaa agaacaucuc aagcaaauga cuuugcagcu ugaacucaag      120

cagauucccu ggacugaggu caaaaaagca ucccgggaag aacuugcaaa ccucuugauc      180

aagcacuaug aagaacaaca agcuuggaac auaaccuuaa gaaucuuuca aaagauggau      240

agaaaggauc ucugcaugaa ggucaugagg gagagaacag gauacacaaa gaccuaucaa      300

gcucacgcaa agcagaaauu cagccgcuua ugguccagca agucugucac ugagauucac      360

cuauacuuug aggaggaagu caagcaagaa gaaugugacc auuuggaccg ccuuuuugcu      420

cccaaggaag cugggaaaca gccacguaca gugaucauuc aaggaccaca aggaauugga      480

aaaacgacac uccugaugaa gcugaugaug gccuggucgg acaacaagau cuuucgggau      540

agguuccugu acacguucua uuucugcugc agagaacuga gggaguugcc gccaacgagu      600

uuggcugacu ugauuuccag agaguggccu gaccccgcug cuccuauaac agagaucgug      660

ucucaaccgg agagacucuu guucgucauc gacagcuucg aagagcugca gggcggcuug      720

aacgaacccg auucggaucu guguggugac uugauggaga aacggccggu gcaggugcuu      780

cugagcaguu ugcugaggaa gaagaugcuc ccggaggccu cccugcucau cgcuaucaaa      840

cccgugugcc cgaaggagcu ccgggaucag gugacgaucu cagaaaucua ccagccccgg      900

ggauucaacg agagugauag guuaguguau uucugcuguu ucuucaaaga cccgaaaaga      960

gccauggaag ccuucaaucu uguaagagaa agugaacagc uguuuuccau augccaaauc     1020

ccgcuccucu gcuggauccu guguaccagu cugaagcaag agaugcagaa aggaaaagac     1080

cuggcccuga ccugccagag cacuaccucu guguacuccu cuuucgucuu uaaccuguuc     1140

acaccugagg gugccgaggg cccgacuccg caaacccagc accagcugaa ggcccugugc     1200

ucccuggcug cagaggguau guggacagac acauuugagu uuugugaaga cgaccuccgg     1260

agaaaugggg uuguugacgc ugacaucccu gcgcugcugg gcaccaagau acuucugaag     1320

uacggggagc gugagagcuc cuacguguuc cuccacgugu guauccagga guucugugcc     1380

gccuuguucu auuugcucaa gagccaccuu gaucauccuc acccagcugu gagaugugua     1440

caggaauugc uaguugccaa uuuugaaaaa gcaaggagag cacauuggau uuuuuugggg     1500

uguuuucuaa cuggccuuuu aaauaaaaag gaacaagaaa aacuggaugc guuuuuuggc     1560

uuccaacugu cccaagagau aaagcagcaa auucaccagu gccugaagag cuuaggggag     1620

cguggcaauc cucagggaca gguggauucc uuggcgauau uuuacugucu cuuugaaaug     1680

caggauccug ccuuugugaa gcaggcagug aaccuccucc aagaagcuaa cuuucauauu     1740

auugacaacg uggacuuggu gguuucugcc uacugcuuaa aauacugcuc cagcuugagg     1800

aaacucuguu uuuccguuca aaaugucuuu aagaaagagg augaacacag cucuacgucg     1860

gauuacagcc ucaucuguug gcaucacauc ugcucugugc ucaccaccag cgggcaccuc     1920

agagagcucc aggugcagga cagcacccuc agcgagucga ccuuugugac cugguguaac     1980

cagcugaggc aucccagcug ucgccuucag aagcuuggaa uaaauaacgu uuccuuuucu     2040

ggccagagug uucugcucuu ugaggugcuc uuuuaucagc cagacuugaa auaccugagc     2100

uucacccuca cgaaacucuc ucgugaugac aucagguccc ucugugaugc cuugaacuac     2160

ccagcaggca acgucaaaga gcuagcgcug guaaauuguc accucucacc cauugauugu     2220

gaaguccuug cuggccuucu aaccaacaac aagaagcuga cguaucugaa uguauccugc     2280

aaccaguuag acacaggcgu gccccuuuug ugugaagccc ugugcagccc agacacgguc     2340

cugguauacc ugauguuggc uuucugccac cucagcgagc agugcugcga auacaucucu     2400

gaaaugcuuc ugcguaacaa gagcgugcgc uaucuagacc ucagugccaa uguccugaag     2460

gacgaaggac ugaaaacucu cugcgaggcc uugaaacauc cggacugcug ccuggauuca     2520

cuguguuugg uaaaauguuu uaucacugcu gcuggcugug aagaccucgc cucugcucuc     2580

aucagcaauc aaaaccugaa gauucugcaa auugggugca augaaaucgg agaugugggu     2640

gugcagcugu ugugucgggc ucugacgcau acggauugcc gcuuagagau ucuuggguug     2700

gaagaaugug gguuaacgag caccugcugu aaggaucucg cgucuguucu caccugcagu     2760

aagacccugc agcagcucaa ccugaccuug aacaccuugg accacacagg ggugguugua     2820

cucugugagg cccugagaca cccagagugu gcccugcagg ugcucgggcu gagaaaaacu     2880

gauuuugaug aggaaaccca ggcacuucug acggcugagg aagagagaaa uccuaaccug     2940

accaucacag acgacuguga cacaaucaca aggguagaga ucuga                     2985


<210>  9076
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP4__Homo_sapiens__CCDS12936.1

<400>  9076
auggccgcca gcuucuucuc cgacuucggc cugauguggu accucgagga gcugaagaag       60

gaggaguucc gcaaguucaa ggagcaccug aagcagauga cccuccagcu ggagcugaag      120

cagauccccu ggaccgaggu gaagaaggcg agccgggagg agcucgccaa ccugcugauc      180

aagcacuacg aggagcagca ggccuggaac aucacgcucc gcaucuucca gaagauggac      240

cggaaggacc ugugcaugaa ggucaugcgc gagcggaccg gguacaccaa gaccuaccag      300

gcccacgcca agcagaaguu cucccgccug uggagcucca agagcgugac ggagauccac      360

cucuacuucg aggaggaggu gaagcaggag gagugcgacc accuggaccg gcuguucgcg      420

ccgaaggagg ccggcaagca gccccgcacc gucaucaucc aggggcccca gggcaucggg      480

aagaccaccc uccugaugaa gcugaugaug gccugguccg acaacaagau cuuccgggac      540

cgcuuccucu acacguucua cuucugcugc cgggagcugc gcgagcugcc cccgaccagc      600

cucgccgacc ugaucucccg ggaguggccc gaccccgcgg cccccaucac cgagaucgug      660

agccagccgg agcgccuccu cuucgugauc gacuccuucg aggagcugca gggcggccug      720

aacgagcccg acagcgaccu cugcggggac cugauggaga agcggcccgu ccaggugcug      780

cucuccagcc ugcugcgcaa gaagaugcuc cccgaggccu cccugcugau cgccaucaag      840

ccggugugcc ccaaggagcu ccgggaccag gucaccauca gcgagaucua ccagccccgc      900

ggcuucaacg aguccgaccg gcugguguac uucugcugcu ucuucaagga ccccaagcgc      960

gccauggagg cguucaaccu ggugcgggag agcgagcagc uguucuccau cugccagauc     1020

ccgcugcugu gcuggauccu cugcacgagc cugaagcagg agaugcagaa ggggaaggac     1080

cuggcccuga ccugccagag caccaccucc gucuacagcu ccuucguguu caaccuguuc     1140

acgcccgagg gcgccgaggg gcccacgccc cagacccagc accagcugaa ggcccucugc     1200

agccuggccg cggagggcau guggaccgac accuucgagu ucugcgagga cgaccugcgc     1260

cgcaacggcg uggucgacgc cgacaucccg gcccugcucg ggaccaagau ccugcugaag     1320

uacggcgagc gggaguccag cuacguguuc cuccacgugu gcauccagga guucugcgcc     1380

gcccuguucu accugcucaa gucccaccug gaccaccccc accccgcggu ccgcugcgug     1440

caggagcugc ucguggccaa cuucgagaag gcccggcgcg cccacuggau cuuccugggg     1500

ugcuuccuga ccggccuccu gaacaagaag gagcaggaga agcuggacgc cuucuucggc     1560

uuccagcuca gccaggagau caagcagcag auccaccagu gccugaaguc ccugggggag     1620

cggggcaacc cccaggggca ggucgacagc cucgcgaucu ucuacugccu guucgagaug     1680

caggacccgg ccuucgugaa gcaggccgug aaccugcucc aggaggccaa cuuccacauc     1740

aucgacaacg ucgaccuggu ggucuccgcg uacugccuga aguacugcag cucccuccgc     1800

aagcugugcu ucagcgugca gaacguguuc aagaaggagg acgagcacuc cagcaccucc     1860

gacuacagcc ugaucugcug gcaccacauc ugcuccgucc ucacgaccag cggccaccuc     1920

cgggagcucc aggugcagga cagcacccuc uccgagagca ccuucgugac guggugcaac     1980

cagcugcgcc accccuccug ccggcugcag aagcucggga ucaacaacgu cagcuucucc     2040

ggccagagcg ugcugcuguu cgaggugcug uucuaccagc ccgaccugaa guaccugucc     2100

uucacccuca ccaagcugag ccgcgacgac auccgguccc ugugcgacgc ccucaacuac     2160

cccgccggca acgucaagga gcuggcccug gugaacugcc accucagccc gaucgacugc     2220

gaggugcugg ccgggcugcu caccaacaac aagaagcuga cguaccugaa cgucuccugc     2280

aaccagcucg acaccggcgu gccccugcug ugcgaggcgc ucugcagccc cgacaccgug     2340

cuggucuacc ugaugcucgc cuucugccac cuguccgagc agugcugcga guacaucagc     2400

gagaugcugc uccgcaacaa guccgugcgg uaccuggacc ugagcgccaa cgugcucaag     2460

gacgaggggc ugaagacccu gugcgaggcc cucaagcacc cggacugcug ccuggacucc     2520

cugugccucg ucaagugcuu caucacggcc gcgggcugcg aggaccuggc cagcgcccug     2580

aucagcaacc agaaccucaa gauccugcag aucgggugca acgagaucgg cgacgugggc     2640

gugcagcugc ucugccgcgc ccugacccac accgacugcc ggcuggagau ccucgggcug     2700

gaggagugcg gccugaccuc cacgugcugc aaggaccucg ccagcguccu gaccugcucc     2760

aagacccugc agcagcucaa ccugacccug aacacccucg accacacggg gguggugguc     2820

cugugcgagg cgcugcgcca ccccgagugc gcccuccagg ugcugggccu gcggaagacc     2880

gacuucgacg aggagaccca ggcccuccug accgccgagg aggagcgcaa ccccaaccug     2940

acgaucaccg acgacugcga caccaucacc cggguggaga ucuga                     2985


<210>  9077
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP4__Homo_sapiens__CCDS12936.1

<400>  9077
auggccgccu ccuucuucuc cgacuucggc cucauguggu accucgagga gcucaagaag       60

gaggaguucc gcaaguucaa ggagcaccuc aagcagauga cccuccagcu cgagcucaag      120

cagauccccu ggaccgaggu caagaaggcc ucccgcgagg agcucgccaa ccuccucauc      180

aagcacuacg aggagcagca ggccuggaac aucacccucc gcaucuucca gaagauggac      240

cgcaaggacc ucugcaugaa ggucaugcgc gagcgcaccg gcuacaccaa gaccuaccag      300

gcccacgcca agcagaaguu cucccgccuc ugguccucca aguccgucac cgagauccac      360

cucuacuucg aggaggaggu caagcaggag gagugcgacc accucgaccg ccucuucgcc      420

cccaaggagg ccggcaagca gccccgcacc gucaucaucc agggccccca gggcaucggc      480

aagaccaccc uccucaugaa gcucaugaug gccugguccg acaacaagau cuuccgcgac      540

cgcuuccucu acaccuucua cuucugcugc cgcgagcucc gcgagcuccc ccccaccucc      600

cucgccgacc ucaucucccg cgaguggccc gaccccgccg cccccaucac cgagaucguc      660

ucccagcccg agcgccuccu cuucgucauc gacuccuucg aggagcucca gggcggccuc      720

aacgagcccg acuccgaccu cugcggcgac cucauggaga agcgccccgu ccagguccuc      780

cucuccuccc uccuccgcaa gaagaugcuc cccgaggccu cccuccucau cgccaucaag      840

cccgucugcc ccaaggagcu ccgcgaccag gucaccaucu ccgagaucua ccagccccgc      900

ggcuucaacg aguccgaccg ccucgucuac uucugcugcu ucuucaagga ccccaagcgc      960

gccauggagg ccuucaaccu cguccgcgag uccgagcagc ucuucuccau cugccagauc     1020

ccccuccucu gcuggauccu cugcaccucc cucaagcagg agaugcagaa gggcaaggac     1080

cucgcccuca ccugccaguc caccaccucc gucuacuccu ccuucgucuu caaccucuuc     1140

acccccgagg gcgccgaggg ccccaccccc cagacccagc accagcucaa ggcccucugc     1200

ucccucgccg ccgagggcau guggaccgac accuucgagu ucugcgagga cgaccuccgc     1260

cgcaacggcg ucgucgacgc cgacaucccc gcccuccucg gcaccaagau ccuccucaag     1320

uacggcgagc gcgaguccuc cuacgucuuc cuccacgucu gcauccagga guucugcgcc     1380

gcccucuucu accuccucaa gucccaccuc gaccaccccc accccgccgu ccgcugcguc     1440

caggagcucc ucgucgccaa cuucgagaag gcccgccgcg cccacuggau cuuccucggc     1500

ugcuuccuca ccggccuccu caacaagaag gagcaggaga agcucgacgc cuucuucggc     1560

uuccagcucu cccaggagau caagcagcag auccaccagu gccucaaguc ccucggcgag     1620

cgcggcaacc cccagggcca ggucgacucc cucgccaucu ucuacugccu cuucgagaug     1680

caggaccccg ccuucgucaa gcaggccguc aaccuccucc aggaggccaa cuuccacauc     1740

aucgacaacg ucgaccucgu cgucuccgcc uacugccuca aguacugcuc cucccuccgc     1800

aagcucugcu ucuccgucca gaacgucuuc aagaaggagg acgagcacuc cuccaccucc     1860

gacuacuccc ucaucugcug gcaccacauc ugcuccgucc ucaccaccuc cggccaccuc     1920

cgcgagcucc agguccagga cuccacccuc uccgagucca ccuucgucac cuggugcaac     1980

cagcuccgcc accccuccug ccgccuccag aagcucggca ucaacaacgu cuccuucucc     2040

ggccaguccg uccuccucuu cgagguccuc uucuaccagc ccgaccucaa guaccucucc     2100

uucacccuca ccaagcucuc ccgcgacgac auccgcuccc ucugcgacgc ccucaacuac     2160

cccgccggca acgucaagga gcucgcccuc gucaacugcc accucucccc caucgacugc     2220

gagguccucg ccggccuccu caccaacaac aagaagcuca ccuaccucaa cgucuccugc     2280

aaccagcucg acaccggcgu cccccuccuc ugcgaggccc ucugcucccc cgacaccguc     2340

cucgucuacc ucaugcucgc cuucugccac cucuccgagc agugcugcga guacaucucc     2400

gagaugcucc uccgcaacaa guccguccgc uaccucgacc ucuccgccaa cguccucaag     2460

gacgagggcc ucaagacccu cugcgaggcc cucaagcacc ccgacugcug ccucgacucc     2520

cucugccucg ucaagugcuu caucaccgcc gccggcugcg aggaccucgc cuccgcccuc     2580

aucuccaacc agaaccucaa gauccuccag aucggcugca acgagaucgg cgacgucggc     2640

guccagcucc ucugccgcgc ccucacccac accgacugcc gccucgagau ccucggccuc     2700

gaggagugcg gccucaccuc caccugcugc aaggaccucg ccuccguccu caccugcucc     2760

aagacccucc agcagcucaa ccucacccuc aacacccucg accacaccgg cgucgucguc     2820

cucugcgagg cccuccgcca ccccgagugc gcccuccagg uccucggccu ccgcaagacc     2880

gacuucgacg aggagaccca ggcccuccuc accgccgagg aggagcgcaa ccccaaccuc     2940

accaucaccg acgacugcga caccaucacc cgcgucgaga ucuga                     2985


<210>  9078
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP4__Homo_sapiens__CCDS12936.1

<400>  9078
auggccgcua gcuucuuuuc cgacuucggc cugauguggu accucgagga acuuaagaaa       60

gaggaauuua gaaaguucaa agagcaccug aagcagauga ccuugcaauu agaacugaaa      120

cagauccccu ggacagaggu gaagaaggca ucuagggagg aacuagccaa ccuccugauu      180

aaacauuaug aggaacagca ggcguggaau auaacucuuc ggaucuuuca aaagauggau      240

cgcaaagacc ugugcaugaa ggucaugcga gagcguacgg gguacaccaa aacauaucag      300

gcucacgcca agcagaaguu cucaagauug uggaguagca aauccguuac ugagauucau      360

cucuacuuug aagaggaagu gaagcaggag gaaugugauc accuggacag gcuguucgca      420

ccuaaagagg ccggaaagca accacggacc guaaucauuc aggguccgca gggcaucggg      480

aaaacaaccc ucuuaaugaa gcugaugaug gcuuggucug auaacaaaau auuucgcgac      540

agauuccuuu auacuuuuua cuucugcugu agggaguugc gggaacugcc cccuacaucg      600

cuagcagauc ucaucucacg cgaguggcca gaccccgccg cuccuauuac cgaaaucgug      660

agccagccag agcgacugcu uuuugucauu gauaguuucg aagaacugca aggaggcuug      720

aaugagcccg acuccgaucu cugcggugac cugauggaaa agagaccugu gcagguuuua      780

cugucuagcc uccuuaggaa gaaaaugcug ccagaggccu ccuugcuaau cgcgauaaag      840

ccgguguguc ccaaagaacu gcgggaucag gucacgauuu cagagaucua ucaaccucgu      900

ggguucaacg aaagugaccg ccucguguac uuuugcuguu ucuuuaagga cccaaaaaga      960

gcaauggagg ccuucaaucu gguaagggag agcgaacagc ucuuuucuau uugccagauc     1020

ccccuguugu guuggauccu cugcacuucc cugaagcagg agaugcaaaa gggaaaagau     1080

uuagcucuga ccugucaguc aacaacuagc guuuacaguu cuuucguguu uaaccuauuc     1140

accccugaag gcgccgaggg cccaacaccc cagacccagc aucaacucaa ggcacugugc     1200

ucccuugcug ccgaggggau guggacggac acuuuugaau uuugcgagga ugacuugcgg     1260

cgaaauggag ucguggaugc ggacauuccg gcccugcucg guacaaaaau acugcuuaag     1320

uauggcgaac gcgagagcuc guacguguuu cugcacgucu guauccagga guucugcgca     1380

gcuuuguuuu aucuccugaa aucucacuua gaucauccuc accccgccgu uagaugugug     1440

caggagcugc uaguagcuaa cuucgagaag gccaggcggg cacauuggau uuuccucggg     1500

ugcuuucuga ccggacuuuu gaauaagaaa gaacaggaga agcuggacgc cuucuuuggc     1560

uuccaacucu cccaggaaau caaacagcag auacaccaau gucugaaguc auuaggugag     1620

cgcgggaacc cacagggaca gguggauagu cuggcuauuu ucuacugccu uuucgaaaug     1680

caagacccug cguuugucaa acaggcagug aauuugcucc aggaggccaa cuuccacauc     1740

aucgauaaug uugaccuggu ggucagcgcu uauugucuaa aguacugcuc cucucugaga     1800

aagcucuguu uuagcgugca gaacguauuc aaaaaggagg acgaacauuc aaguacuucc     1860

gauuauagcc ugauuugcug gcaccauauc uguucuguuc uuacaaccuc aggccacuug     1920

agggagcugc aagugcagga caguacguua agcgaaucca ccuuugucac auggugcaau     1980

cagcuccguc aucccucuug ccggcugcag aaacuuggca uuaacaacgu gucguucagc     2040

gggcaauccg uccuguuguu ugaggugcuu uucuaccagc cagaucugaa guaccuauca     2100

uucacucuga ccaaacucag ucgagacgau auaagaucuc ugugugacgc ccuuaauuau     2160

cccgcaggaa acguuaagga auuggcccug gugaauugcc acuuaagccc uaucgauugu     2220

gagguacucg cuggucugcu uacaaacaau aaaaagcuga cuuaccuaaa cgucuccugc     2280

aaucagcucg acaccggcgu gccacuguug ugugaggccc ugugcucacc ggauacaguu     2340

uuaguguauc ucaugcuggc auuuugucac cuuagcgaac agugcuguga guacauuucu     2400

gaaaugcugu ugaggaacaa guccguccgc uaucucgacc ugagugcgaa ugugcuaaaa     2460

gaugaggggc ugaagacccu uugcgaggcu cucaaacauc ccgacuguug ccuggauagc     2520

uugugccugg uaaaguguuu caucacugcc gcaggaugcg aagacuuagc cucugcucuc     2580

aucuccaacc aaaaucugaa aauucuucag auaggcugua acgagaucgg ugacgugggg     2640

guucagcugu ugugccgggc ccucacgcac acagauugua gacuggaaau ucuaggccug     2700

gaggaaugcg gacuuaccuc aacuuguugc aaggaccucg caaguguccu gaccuguagc     2760

aagacauugc aacaguuaaa ucugacccuc aacacucugg aucauacagg cguggugguc     2820

cuuugcgagg cucugaggca cccugagugu gccuugcagg uucuagggcu gcgcaaaacg     2880

gacuuugaug aagagaccca ggcgcuccug acugccgaag aggaacgaaa uccaaaccuu     2940

acaaucaccg acgauugcga cacaauuacu cggguggaga ucuga                     2985


<210>  9079
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP4__Homo_sapiens__CCDS12936.1

<400>  9079
auggccgcca gcuucuucag cgacuucggc cugauguggu accuggagga gcugaagaag       60

gaggaguuca gaaaguucaa ggagcaccug aagcagauga cccugcagcu ggagcugaag      120

cagauccccu ggaccgaggu gaagaaggcc agcagagagg agcuggccaa ccugcugauc      180

aagcacuacg aggagcagca ggccuggaac aucacccuga gaaucuucca gaagauggac      240

agaaaggacc ugugcaugaa ggugaugaga gagagaaccg gcuacaccaa gaccuaccag      300

gcccacgcca agcagaaguu cagcagacug uggagcagca agagcgugac cgagauccac      360

cuguacuucg aggaggaggu gaagcaggag gagugcgacc accuggacag acuguucgcc      420

cccaaggagg ccggcaagca gcccagaacc gugaucaucc agggccccca gggcaucggc      480

aagaccaccc ugcugaugaa gcugaugaug gccuggagcg acaacaagau cuucagagac      540

agauuccugu acaccuucua cuucugcugc agagagcuga gagagcugcc ccccaccagc      600

cuggccgacc ugaucagcag agaguggccc gaccccgccg cccccaucac cgagaucgug      660

agccagcccg agagacugcu guucgugauc gacagcuucg aggagcugca gggcggccug      720

aacgagcccg acagcgaccu gugcggcgac cugauggaga agagacccgu gcaggugcug      780

cugagcagcc ugcugagaaa gaagaugcug cccgaggcca gccugcugau cgccaucaag      840

cccgugugcc ccaaggagcu gagagaccag gugaccauca gcgagaucua ccagcccaga      900

ggcuucaacg agagcgacag acugguguac uucugcugcu ucuucaagga ccccaagaga      960

gccauggagg ccuucaaccu ggugagagag agcgagcagc uguucagcau cugccagauc     1020

ccccugcugu gcuggauccu gugcaccagc cugaagcagg agaugcagaa gggcaaggac     1080

cuggcccuga ccugccagag caccaccagc guguacagca gcuucguguu caaccuguuc     1140

acccccgagg gcgccgaggg ccccaccccc cagacccagc accagcugaa ggcccugugc     1200

agccuggccg ccgagggcau guggaccgac accuucgagu ucugcgagga cgaccugaga     1260

agaaacggcg ugguggacgc cgacaucccc gcccugcugg gcaccaagau ccugcugaag     1320

uacggcgaga gagagagcag cuacguguuc cugcacgugu gcauccagga guucugcgcc     1380

gcccuguucu accugcugaa gagccaccug gaccaccccc accccgccgu gagaugcgug     1440

caggagcugc ugguggccaa cuucgagaag gccagaagag cccacuggau cuuccugggc     1500

ugcuuccuga ccggccugcu gaacaagaag gagcaggaga agcuggacgc cuucuucggc     1560

uuccagcuga gccaggagau caagcagcag auccaccagu gccugaagag ccugggcgag     1620

agaggcaacc cccagggcca gguggacagc cuggccaucu ucuacugccu guucgagaug     1680

caggaccccg ccuucgugaa gcaggccgug aaccugcugc aggaggccaa cuuccacauc     1740

aucgacaacg uggaccuggu ggugagcgcc uacugccuga aguacugcag cagccugaga     1800

aagcugugcu ucagcgugca gaacguguuc aagaaggagg acgagcacag cagcaccagc     1860

gacuacagcc ugaucugcug gcaccacauc ugcagcgugc ugaccaccag cggccaccug     1920

agagagcugc aggugcagga cagcacccug agcgagagca ccuucgugac cuggugcaac     1980

cagcugagac accccagcug cagacugcag aagcugggca ucaacaacgu gagcuucagc     2040

ggccagagcg ugcugcuguu cgaggugcug uucuaccagc ccgaccugaa guaccugagc     2100

uucacccuga ccaagcugag cagagacgac aucagaagcc ugugcgacgc ccugaacuac     2160

cccgccggca acgugaagga gcuggcccug gugaacugcc accugagccc caucgacugc     2220

gaggugcugg ccggccugcu gaccaacaac aagaagcuga ccuaccugaa cgugagcugc     2280

aaccagcugg acaccggcgu gccccugcug ugcgaggccc ugugcagccc cgacaccgug     2340

cugguguacc ugaugcuggc cuucugccac cugagcgagc agugcugcga guacaucagc     2400

gagaugcugc ugagaaacaa gagcgugaga uaccuggacc ugagcgccaa cgugcugaag     2460

gacgagggcc ugaagacccu gugcgaggcc cugaagcacc ccgacugcug ccuggacagc     2520

cugugccugg ugaagugcuu caucaccgcc gccggcugcg aggaccuggc cagcgcccug     2580

aucagcaacc agaaccugaa gauccugcag aucggcugca acgagaucgg cgacgugggc     2640

gugcagcugc ugugcagagc ccugacccac accgacugca gacuggagau ccugggccug     2700

gaggagugcg gccugaccag caccugcugc aaggaccugg ccagcgugcu gaccugcagc     2760

aagacccugc agcagcugaa ccugacccug aacacccugg accacaccgg cgugguggug     2820

cugugcgagg cccugagaca ccccgagugc gcccugcagg ugcugggccu gagaaagacc     2880

gacuucgacg aggagaccca ggcccugcug accgccgagg aggagagaaa ccccaaccug     2940

accaucaccg acgacugcga caccaucacc agaguggaga ucuga                     2985


<210>  9080
<211>  2985
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP4__Homo_sapiens__CCDS12936.1

<400>  9080
auggccgcua gcuucuuuuc cgacuucggc cugauguggu accucgagga acugaagaaa       60

gaggaauuua gaaaguucaa agagcaccuu aagcagauga cccugcaacu cgaacugaaa      120

cagauccccu ggacagaggu gaagaaggcc ucucgggagg aacuugcgaa ccugcucauu      180

aaacauuaug aggaacagca ggcuuggaau aucacgcugc gcauuuuuca aaagauggau      240

agaaaagacc ugugcaugaa ggucaugcgg gagcgcaccg gguacacaaa aaccuaucag      300

gcccacgcca agcagaaguu cagcagacuc ugguccucua aaagcguuac agagauccau      360

cuguacuuug aagaggaagu gaagcaggag gaaugugauc accuugaccg gcuguucgcu      420

ccuaaagagg ccggaaagca accgcgcacc gugauuaucc agggccccca ggggaucgga      480

aaaacaaccc uccugaugaa gcucaugaug gcuugguccg auaacaaaau uuuuagagac      540

cgguuccugu auacguuuua cuucugcugu cgcgagcuca gagaacugcc ucccaccucu      600

cuggccgauc ucaucagccg ggaguggccu gaccccgcgg ccccuauuac agaaaucguc      660

ucccagccgg agcgccugcu uuuugugauu gauagcuucg aggaacugca aggcgggcuc      720

aaugagcccg acucugaucu gugcggagac cuuauggaaa agagaccugu ucaggugcug      780

cucuccagcc ugcugcggaa gaaaaugcuc cccgaggcuu cucugcuuau cgccauuaag      840

ccugucuguc ccaaagaacu gcgcgaucag gugaccaucu ccgagaucua ucaaccgaga      900

ggcuucaacg aaagcgaccg gcucguuuac uuuugcuguu ucuuuaagga cccuaaaaga      960

gcuauggagg ccuucaaucu ggugcgcgag ucugaacagc uuuucuccau uugccagauc     1020

ccccugcucu guuggauucu gugcacaagc cugaagcagg agaugcaaaa gggcaaagau     1080

cucgcgcuga ccugucaguc cacgacaucu gucuacagcu ccuucguguu uaaccuuuuc     1140

accccugaag gggccgaggg acccacaccc cagacccagc aucaacugaa ggcucucugc     1200

agccuggccg cugagggcau guggaccgac acauuugaau uuugcgagga ugaccugcgg     1260

agaaaugggg uggucgaugc cgacaucccu gcccuucucg gaacgaaaau ucugcugaag     1320

uauggcgaac gcgagucuuc cuacguuuuu cuccacgugu guauccagga auuuugcgcu     1380

gcgcuguuuu aucuucugaa aagccaccuc gaucauccgc accccgccgu gcgguguguc     1440

caggagcugc ugguggcuaa cuucgagaag gccagacgcg cccauuggau cuuccuuggg     1500

ugcuuucuca ccggacugcu gaauaagaaa gaacaggaga agcucgacgc uuucuuuggc     1560

uuccaacugu cucaggaaau uaaacagcag auccaccaau gucuuaagag ccugggcgag     1620

cgggggaacc cucagggaca gguugauucc cucgccauuu ucuacugccu guucgaaaug     1680

caagaccccg cguuugugaa acaggcuguc aaucugcuuc aggaggccaa cuuccacauc     1740

auugauaaug uggaccucgu ugugucugcc uauugucuga aguacugcag cucccugaga     1800

aagcucuguu uuagcgucca gaacguguuc aaaaaggagg acgaacauuc uuccacaagc     1860

gauuauucuc ugaucugcug gcaccauauc uguuccgucc uuaccacaag cggccaucug     1920

cgcgagcucc aagugcagga cuccacccug ucugaaagca cguuuguuac auggugcaau     1980

cagcugcggc acccuuccug cagacuucag aaacucggga uuaacaacgu gucuuucagc     2040

ggacaauccg uccugcuguu ugaggugcuu uucuaccagc ccgaucugaa guaccuuagc     2100

uucacccuga ccaaacucuc ucgcgacgau auccgguccc ugugugacgc ucugaauuau     2160

ccggccggca acguuaagga acuugcucug gugaauugcc accucagccc uauugauugu     2220

gagguccugg ccgggcuccu gacaaacaau aaaaagcuga ccuaccugaa cgugucuugc     2280

aaucagcucg acacaggagu gccccugcug ugugaggcgc uuugcucccc ugauacgguu     2340

cuggucuauc ucaugcuggc cuuuugucac cucagcgaac agugcuguga guacaucucu     2400

gaaaugcugc uuagaaacaa gagcgugcgg uaucuggacc ucuccgcuaa ugugcugaaa     2460

gaugagggcc ugaagacccu uugcgaggcc cugaaacauc ccgacuguug ccucgauagc     2520

cugugccucg ucaaguguuu cauuacagcu gccggcugcg aagaccuggc gucugcccuu     2580

aucuccaacc aaaaucugaa aauucugcag aucgggugua acgagaucgg agacgugggc     2640

guucagcucc ugugccgcgc ucuuacccac acagauugua gacuggaaau ucucgggcug     2700

gaggaaugcg gacucaccag cacguguugc aaggaccugg ccuccgugcu uaccuguucu     2760

aagacacugc aacagcugaa ucucacccug aacacacuug aucauaccgg cgucgugguu     2820

cugugcgagg cucuccggca cccugagugu gcccuucagg ugcucgggcu gagaaaaacg     2880

gacuuugaug aagagacaca ggcccuucug accgcugaag aggaacgcaa ucccaaccug     2940

acaaucaccg acgauugcga caccauuaca cgggucgaga ucuga                     2985


<210>  9081
<211>  1200
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP5__Homo_sapiens__P59047

<400>  9081

Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser 
1               5                   10                  15      


Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser 
            20                  25                  30          


Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro 
        35                  40                  45              


Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile 
                85                  90                  95      


Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu 
            100                 105                 110         


Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser 
        115                 120                 125             


Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp 
    130                 135                 140                 


Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp 
145                 150                 155                 160 


Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile Ser Gln Ala Val Gln 
                165                 170                 175     


Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu Gln Glu Ile Ser Gln 
            180                 185                 190         


Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu 
        195                 200                 205             


Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu 
    210                 215                 220                 


Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met 
225                 230                 235                 240 


Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr 
                245                 250                 255     


Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser 
            260                 265                 270         


Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser 
        275                 280                 285             


Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala 
    290                 295                 300                 


Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro 
305                 310                 315                 320 


Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile 
                325                 330                 335     


Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser 
            340                 345                 350         


Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly 
        355                 360                 365             


Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys 
    370                 375                 380                 


Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys 
                405                 410                 415     


Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile 
            420                 425                 430         


Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu 
        435                 440                 445             


His Gln Lys Thr Gln Gly Leu Arg Ala Ile Met Asn Asn Arg Glu Leu 
    450                 455                 460                 


Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala 
465                 470                 475                 480 


Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln 
                485                 490                 495     


Thr Leu Thr Gly Leu His Ala Ala Phe Val Phe His Gln Leu Thr Pro 
            500                 505                 510         


Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu 
        515                 520                 525             


Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser 
    530                 535                 540                 


Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu 
545                 550                 555                 560 


Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys 
                565                 570                 575     


Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala 
            580                 585                 590         


Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys 
        595                 600                 605             


Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala 
    610                 615                 620                 


Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu 
625                 630                 635                 640 


Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro 
                645                 650                 655     


Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu 
            660                 665                 670         


Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe 
        675                 680                 685             


His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu 
    690                 695                 700                 


Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu 
705                 710                 715                 720 


Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile 
                725                 730                 735     


Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala 
            740                 745                 750         


Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu 
        755                 760                 765             


Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg 
    770                 775                 780                 


Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr 
785                 790                 795                 800 


Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met 
                805                 810                 815     


Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile 
            820                 825                 830         


Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His 
        835                 840                 845             


Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro 
    850                 855                 860                 


Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His 
865                 870                 875                 880 


Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu 
                885                 890                 895     


Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Met 
            900                 905                 910         


Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu 
        915                 920                 925             


Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala 
    930                 935                 940                 


Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn 
945                 950                 955                 960 


Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg 
                965                 970                 975     


Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu 
            980                 985                 990         


Asp Thr Ala Gly Cys Gly Phe Leu Ala Leu Ala Leu Met Gly Asn Ser 
        995                 1000                1005            


Trp Leu Thr His Leu Ser Leu Ser Met Asn Pro Val Glu Asp Asn Gly 
    1010                1015                1020                


Val Lys Leu Leu Cys Glu Val Met Arg Glu Pro Ser Cys His Leu Gln 
1025                1030                1035                1040


Asp Leu Glu Leu Val Lys Cys His Leu Thr Ala Ala Cys Cys Glu Ser 
                1045                1050                1055    


Leu Ser Cys Val Ile Ser Arg Ser Arg His Leu Lys Ser Leu Asp Leu 
            1060                1065                1070        


Thr Asp Asn Ala Leu Gly Asp Gly Gly Val Ala Ala Leu Cys Glu Gly 
        1075                1080                1085            


Leu Lys Gln Lys Asn Ser Val Leu Ala Arg Leu Gly Leu Lys Ala Cys 
    1090                1095                1100                


Gly Leu Thr Ser Asp Cys Cys Glu Ala Leu Ser Leu Ala Leu Ser Cys 
1105                1110                1115                1120


Asn Arg His Leu Thr Ser Leu Asn Leu Val Gln Asn Asn Phe Ser Pro 
                1125                1130                1135    


Lys Gly Met Met Lys Leu Cys Ser Ala Phe Ala Cys Pro Thr Ser Asn 
            1140                1145                1150        


Leu Gln Ile Ile Gly Leu Trp Lys Trp Gln Tyr Pro Val Gln Ile Arg 
        1155                1160                1165            


Lys Leu Leu Glu Glu Val Gln Leu Leu Lys Pro Arg Val Val Ile Asp 
    1170                1175                1180                


Gly Ser Trp His Ser Phe Asp Glu Asp Asp Arg Tyr Trp Trp Lys Asn 
1185                1190                1195                1200






<210>  9082
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP5__Homo_sapiens__CCDS12938.1

<400>  9082
augaagguug caggaggacu ugaacuugga gcugcugcuc ugcucucagc aucaccacgu       60

gcucuuguca cucuuuccac agguccuacu ugcucuauau uaccaaagaa uccacuuuuc      120

ccccaaaacc ugagcucuca gccuuguauc aagauggaag gagacaaauc gcucaccuuu      180

uccagcuacg ggcugcaaug gugucucuau gagcuagaca aggaagaauu ucagacauuc      240

aaggaauuac uaaagaagaa aucuucagaa ucgaccacau gcucuauucc acaguuugaa      300

aucgagaaug ccaacgugga augucuggca cuccucuugc augaguauua uggagcaucg      360

cuggccuggg cuacguccau uagcaucuuu gaaaacauga accugcgaac ccucucggag      420

aaggcacggg augacaugaa aagacauuca ccagaagauc cugaagcaac gaugacugac      480

caaggaccaa gcaaggaaaa agugccagga auuucacaag cugugcaaca agauagugcc      540

acagcugcag agacaaaaga acaagaaauu ucacaagcua uggaacaaga aggugccaca      600

gcagcagaga cagaagaaca agaaauuuca caagcuaugg aacaagaagg ugccacagca      660

gcagagacag aagaacaagg acauggaggu gacacauggg acuacaagag ucacgugaug      720

accaaauucg cugaggagga ggauguacgu cguaguuuug aaaacacugc ugcugacugg      780

ccggaaaugc aaacguuggc uggugcuuuu gauucagacc gguggggcuu ccggccucgc      840

acggugguuc ugcacggaaa gucaggaauu gggaaaucgg cucuagccag aaggaucgug      900

cugugcuggg cgcaaggugg acucuaccag ggaauguucu ccuacgucuu cuuccucccc      960

guuagagaga ugcagcggaa gaaggagagc agugucacag aguucaucuc cagggagugg     1020

ccagacuccc aggcuccggu gacggagauc augucccgac cagaaaggcu guuguucauc     1080

auugacgguu ucgaugaccu gggcucuguc cucaacaaug acacaaagcu cugcaaagac     1140

ugggcugaga agcagccucc guucacccuc auacgcaguc ugcugaggaa gguccugcuc     1200

ccugaguccu uccugaucgu caccgucaga gacgugggca cagagaagcu caagucagag     1260

gucgugucuc cccguuaccu guuaguuaga ggaaucuccg gggaacaaag aauccacuug     1320

cuccuugagc gcgggauugg ugagcaucag aagacacaag gguugcgugc gaucaugaac     1380

aaccgugagc ugcucgacca gugccaggug cccgccgugg gcucucucau cugcguggcc     1440

cugcagcugc aggacguggu gggggagagc gucgcccccu ucaaccaaac gcucacaggc     1500

cugcacgccg cuuuuguguu ucaucagcuc accccucgag gcgugguccg gcgcugucuc     1560

aaucuggagg aaagaguugu ccugaagcgc uucugccgua uggcugugga gggagugugg     1620

aauaggaagu caguguuuga cggugacgac cucaugguuc aaggacucgg ggagucugag     1680

cuccgugcuc uguuucacau gaacauccuu cucccagaca gccacuguga ggaguacuac     1740

accuucuucc accucagucu ccaggacuuc ugugccgccu uguacuacgu guuagagggc     1800

cuggaaaucg agccagcucu cugcccucug uacguugaga agacaaagag guccauggag     1860

cuuaaacagg caggcuucca uauccacucg cuuuggauga agcguuucuu guuuggccuc     1920

gugagcgaag acguaaggag gccacuggag guccugcugg gcugucccgu uccccugggg     1980

gugaagcaga agcuucugca cugggucucu cuguuggguc agcagccuaa ugccaccacc     2040

ccaggagaca cccuggacgc cuuccacugu cuuuucgaga cucaagacaa agaguuuguu     2100

cgcuuggcau uaaacagcuu ccaagaagug uggcuuccga uuaaccagaa ccuggacuug     2160

auagcaucuu ccuucugccu ccagcacugu ccguauuugc ggaaaauucg gguggauguc     2220

aaagggaucu ucccaagaga ugaguccgcu gaggcauguc cugugguccc ucuauggaug     2280

cgggauaaga cccucauuga ggagcagugg gaagauuucu gcuccaugcu uggcacccac     2340

ccacaccugc ggcagcugga ccugggcagc agcauccuga cagagcgggc caugaagacc     2400

cugugugcca agcugaggca ucccaccugc aagauacaga cccugauguu uagaaaugca     2460

cagauuaccc cuggugugca gcaccucugg agaaucguca uggccaaccg uaaccuaaga     2520

ucccucaacu ugggaggcac ccaccugaag gaagaggaug uaaggauggc gugugaagcc     2580

uuaaaacacc caaaauguuu guuggagucu uugaggcugg auugcugugg auugacccau     2640

gccuguuacc ugaagaucuc ccaaauccuu acgaccuccc ccagccugaa aucucugagc     2700

cuggcaggaa acaaggugac agaccaggga guaaugccuc ucagugaugc cuugagaguc     2760

ucccagugcg cccugcagaa gcugauacug gaggacugug gcaucacagc cacggguugc     2820

cagagucugg ccucagcccu cgucagcaac cggagcuuga cacaccugug ccuauccaac     2880

aacagccugg ggaacgaagg uguaaaucua cugugucgau ccaugaggcu uccccacugu     2940

agucugcaga ggcugaugcu gaaucagugc caccuggaca cggcuggcug ugguuuucuu     3000

gcacuugcgc uuauggguaa cucauggcug acgcaccuga gccuuagcau gaacccugug     3060

gaagacaaug gcgugaagcu ucugugcgag gucaugagag aaccaucuug ucaucuccag     3120

gaccuggagu ugguaaagug ucaucucacc gccgcgugcu gugagagucu guccugugug     3180

aucucgagga gcagacaccu gaagagccug gaucucacgg acaaugcccu gggugacggu     3240

gggguugcug cgcugugcga gggacugaag caaaagaaca guguucuggc gagacucggg     3300

uugaaggcau guggacugac uucugauugc ugugaggcac ucuccuuggc ccuuuccugc     3360

aaccggcauc ugaccagucu aaaccuggug cagaauaacu ucagucccaa aggaaugaug     3420

aagcuguguu cggccuuugc cugucccacg ucuaacuuac agauaauugg gcuguggaaa     3480

uggcaguacc cugugcaaau aaggaagcug cuggaggaag ugcagcuacu caagccccga     3540

gucguaauug acgguaguug gcauucuuuu gaugaagaug accgguacug guggaaaaac     3600

uga                                                                   3603


<210>  9083
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP5__Homo_sapiens__CCDS12938.1

<400>  9083
augaaggugg ccggcgggcu ggagcucggc gccgcggccc ugcugagcgc cagcccccgc       60

gcccucguca cccugagcac cgggccgacg ugcuccaucc ugcccaagaa cccccucuuc      120

ccccagaacc ugagcuccca gccgugcauc aagauggagg gcgacaagag ccugaccuuc      180

uccagcuacg ggcuccagug gugccuguac gagcuggaca aggaggaguu ccagaccuuc      240

aaggagcucc ugaagaagaa guccagcgag uccaccacgu gcagcauccc ccaguucgag      300

aucgagaacg ccaacgugga gugccuggcg cuccugcugc acgaguacua cggcgccucc      360

cucgccuggg ccaccagcau cuccaucuuc gagaacauga accugcggac ccugagcgag      420

aaggcgcgcg acgacaugaa gcggcacucc cccgaggacc ccgaggccac caugacggac      480

cagggcccga gcaaggagaa ggugcccggg aucucccagg ccguccagca ggacagcgcc      540

accgccgcgg agaccaagga gcaggagauc agccaggcca uggagcagga gggcgccacc      600

gccgccgaga cggaggagca ggagaucucc caggcgaugg agcaggaggg ggccaccgcc      660

gccgagaccg aggagcaggg ccacgggggc gacaccuggg acuacaagag ccacgugaug      720

acgaaguucg ccgaggagga ggacgugcgc cgguccuucg agaacaccgc ggccgacugg      780

cccgagaugc agacccucgc cggcgccuuc gacagcgacc gcuggggguu ccggccccgc      840

accgucgugc ugcacggcaa guccgggauc ggcaagagcg cccuggcgcg gcgcaucgug      900

cucugcuggg cccagggcgg gcuguaccag ggcauguucu ccuacgucuu cuuccugccg      960

gugcgggaga ugcagcgcaa gaaggagagc uccgugacgg aguucaucag ccgggagugg     1020

cccgacuccc aggcccccgu caccgagauc augagccgcc ccgagcggcu ccuguucauc     1080

aucgacgggu ucgacgaccu gggcuccgug cucaacaacg acaccaagcu gugcaaggac     1140

ugggccgaga agcagccgcc cuucacccug auccgcagcc uccugcggaa ggugcugcuc     1200

cccgaguccu uccugaucgu cacggugcgc gacgugggga ccgagaagcu gaaguccgag     1260

gucgugagcc cccgguaccu ccuggugcgc ggcaucagcg gcgagcagcg gauccaccuc     1320

cugcuggagc gcgggaucgg cgagcaccag aagacccagg ggcugcgcgc gaucaugaac     1380

aaccgggagc uccuggacca gugccagguc ccggccgugg gcucccugau cugcguggcc     1440

cuccagcugc aggacgucgu gggggagagc gucgcccccu ucaaccagac ccugacgggc     1500

cugcacgccg cguucguguu ccaccagcuc acgccccgcg gcgugguccg gcgcugccug     1560

aaccuggagg agcggguggu gcucaagcgc uucugccgga uggccgucga gggggugugg     1620

aaccgcaaga gcguguucga cggcgacgac cugauggucc aggggcuggg cgaguccgag     1680

cuccgggccc uguuccacau gaacauccug cuccccgaca gccacugcga ggaguacuac     1740

accuucuucc accugucccu gcaggacuuc ugcgccgccc ucuacuacgu gcuggagggg     1800

cuggagaucg agccggcgcu cugcccccug uacguggaga agaccaagcg cagcauggag     1860

cugaagcagg ccggcuucca cauccacucc cucuggauga agcgguuccu guucggccug     1920

gucagcgagg acgugcgccg gccccucgag gugcugcugg ggugccccgu cccgcucggc     1980

gugaagcaga agcugcugca cugggugucc cuccuggggc agcagcccaa cgccaccacc     2040

cccggcgaca cccuggacgc cuuccacugc cucuucgaga cccaggacaa ggaguucguc     2100

cgccuggccc ugaacagcuu ccaggaggug uggcucccga ucaaccagaa ccuggaccug     2160

aucgcgucca gcuucugccu ccagcacugc cccuaccugc ggaagauccg cguggacguc     2220

aagggcaucu ucccccggga cgaguccgcc gaggccugcc ccguggugcc gcuguggaug     2280

cgcgacaaga cgcucaucga ggagcagugg gaggacuucu gcagcaugcu ggggacccac     2340

ccccaccucc ggcagcugga ccugggcucc agcauccuga ccgagcgcgc caugaagacc     2400

cucugcgcga agcugcgcca cccgaccugc aagauccaga cgcugauguu ccggaacgcc     2460

cagaucaccc ccggggucca gcaccucugg cgcaucguga uggccaaccg gaaccugcgc     2520

ucccugaacc ucggcgggac ccaccugaag gaggaggacg ugcggauggc cugcgaggcc     2580

cugaagcacc ccaagugccu ccuggagagc cugcgccucg acugcugcgg ccugacccac     2640

gcgugcuacc ugaagaucuc ccagauccuc acgaccagcc ccagccugaa gucccugagc     2700

cucgccggca acaaggucac cgaccagggg gugaugcccc uguccgacgc ccugcgggug     2760

agccagugcg cccuccagaa gcugauccug gaggacugcg gcaucaccgc cacggggugc     2820

cagucccucg cgagcgcccu ggucuccaac cgcagccuga cccaccucug ccuguccaac     2880

aacagccugg gcaacgaggg ggugaaccuc cugugccggu ccaugcgccu gccccacugc     2940

agccuccagc ggcugaugcu gaaccagugc caccucgaca ccgccggcug cggcuuccug     3000

gcccuggccc ucauggggaa cuccuggcug acccaccuga gccucuccau gaacccggug     3060

gaggacaacg gcgucaagcu gcugugcgag gugaugcgcg agcccagcug ccaccuccag     3120

gaccuggagc uggugaagug ccaccucacg gcggccugcu gcgagucccu gagcugcguc     3180

aucucccgga gccgccaccu gaagucccug gaccucaccg acaacgcccu gggggacggc     3240

gggguggccg cgcugugcga gggccucaag cagaagaacu ccgugcuggc ccggcugggc     3300

cucaaggccu gcgggcugac cagcgacugc ugcgaggccc ugucccucgc ccugagcugc     3360

aaccgccacc ugaccucccu caaccugguc cagaacaacu ucagccccaa gggcaugaug     3420

aagcugugcu ccgcguucgc cugccccacg agcaaccucc agaucaucgg gcuguggaag     3480

uggcaguacc cggugcagau ccggaagcug cucgaggagg ugcagcugcu gaagccccgc     3540

gucgugaucg acggcuccug gcacagcuuc gacgaggacg accgguacug guggaagaac     3600

uga                                                                   3603


<210>  9084
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP5__Homo_sapiens__CCDS12938.1

<400>  9084
augaaggucg ccggcggccu cgagcucggc gccgccgccc uccucuccgc cuccccccgc       60

gcccucguca cccucuccac cggccccacc ugcuccaucc uccccaagaa cccccucuuc      120

ccccagaacc ucuccuccca gcccugcauc aagauggagg gcgacaaguc ccucaccuuc      180

uccuccuacg gccuccagug gugccucuac gagcucgaca aggaggaguu ccagaccuuc      240

aaggagcucc ucaagaagaa guccuccgag uccaccaccu gcuccauccc ccaguucgag      300

aucgagaacg ccaacgucga gugccucgcc cuccuccucc acgaguacua cggcgccucc      360

cucgccuggg ccaccuccau cuccaucuuc gagaacauga accuccgcac ccucuccgag      420

aaggcccgcg acgacaugaa gcgccacucc cccgaggacc ccgaggccac caugaccgac      480

cagggccccu ccaaggagaa gguccccggc aucucccagg ccguccagca ggacuccgcc      540

accgccgccg agaccaagga gcaggagauc ucccaggcca uggagcagga gggcgccacc      600

gccgccgaga ccgaggagca ggagaucucc caggccaugg agcaggaggg cgccaccgcc      660

gccgagaccg aggagcaggg ccacggcggc gacaccuggg acuacaaguc ccacgucaug      720

accaaguucg ccgaggagga ggacguccgc cgcuccuucg agaacaccgc cgccgacugg      780

cccgagaugc agacccucgc cggcgccuuc gacuccgacc gcuggggcuu ccgcccccgc      840

accgucgucc uccacggcaa guccggcauc ggcaaguccg cccucgcccg ccgcaucguc      900

cucugcuggg cccagggcgg ccucuaccag ggcauguucu ccuacgucuu cuuccucccc      960

guccgcgaga ugcagcgcaa gaaggagucc uccgucaccg aguucaucuc ccgcgagugg     1020

cccgacuccc aggcccccgu caccgagauc augucccgcc ccgagcgccu ccucuucauc     1080

aucgacggcu ucgacgaccu cggcuccguc cucaacaacg acaccaagcu cugcaaggac     1140

ugggccgaga agcagccccc cuucacccuc auccgcuccc uccuccgcaa gguccuccuc     1200

cccgaguccu uccucaucgu caccguccgc gacgucggca ccgagaagcu caaguccgag     1260

gucgucuccc cccgcuaccu ccucguccgc ggcaucuccg gcgagcagcg cauccaccuc     1320

cuccucgagc gcggcaucgg cgagcaccag aagacccagg gccuccgcgc caucaugaac     1380

aaccgcgagc uccucgacca gugccagguc cccgccgucg gcucccucau cugcgucgcc     1440

cuccagcucc aggacgucgu cggcgagucc gucgcccccu ucaaccagac ccucaccggc     1500

cuccacgccg ccuucgucuu ccaccagcuc accccccgcg gcgucguccg ccgcugccuc     1560

aaccucgagg agcgcgucgu ccucaagcgc uucugccgca uggccgucga gggcgucugg     1620

aaccgcaagu ccgucuucga cggcgacgac cucauggucc agggccucgg cgaguccgag     1680

cuccgcgccc ucuuccacau gaacauccuc cuccccgacu cccacugcga ggaguacuac     1740

accuucuucc accucucccu ccaggacuuc ugcgccgccc ucuacuacgu ccucgagggc     1800

cucgagaucg agcccgcccu cugcccccuc uacgucgaga agaccaagcg cuccauggag     1860

cucaagcagg ccggcuucca cauccacucc cucuggauga agcgcuuccu cuucggccuc     1920

gucuccgagg acguccgccg cccccucgag guccuccucg gcugccccgu cccccucggc     1980

gucaagcaga agcuccucca cugggucucc cuccucggcc agcagcccaa cgccaccacc     2040

cccggcgaca cccucgacgc cuuccacugc cucuucgaga cccaggacaa ggaguucguc     2100

cgccucgccc ucaacuccuu ccaggagguc uggcucccca ucaaccagaa ccucgaccuc     2160

aucgccuccu ccuucugccu ccagcacugc cccuaccucc gcaagauccg cgucgacguc     2220

aagggcaucu ucccccgcga cgaguccgcc gaggccugcc ccgucguccc ccucuggaug     2280

cgcgacaaga cccucaucga ggagcagugg gaggacuucu gcuccaugcu cggcacccac     2340

ccccaccucc gccagcucga ccucggcucc uccauccuca ccgagcgcgc caugaagacc     2400

cucugcgcca agcuccgcca ccccaccugc aagauccaga cccucauguu ccgcaacgcc     2460

cagaucaccc ccggcgucca gcaccucugg cgcaucguca uggccaaccg caaccuccgc     2520

ucccucaacc ucggcggcac ccaccucaag gaggaggacg uccgcauggc cugcgaggcc     2580

cucaagcacc ccaagugccu ccucgagucc cuccgccucg acugcugcgg ccucacccac     2640

gccugcuacc ucaagaucuc ccagauccuc accaccuccc ccucccucaa gucccucucc     2700

cucgccggca acaaggucac cgaccagggc gucaugcccc ucuccgacgc ccuccgcguc     2760

ucccagugcg cccuccagaa gcucauccuc gaggacugcg gcaucaccgc caccggcugc     2820

cagucccucg ccuccgcccu cgucuccaac cgcucccuca cccaccucug ccucuccaac     2880

aacucccucg gcaacgaggg cgucaaccuc cucugccgcu ccaugcgccu cccccacugc     2940

ucccuccagc gccucaugcu caaccagugc caccucgaca ccgccggcug cggcuuccuc     3000

gcccucgccc ucaugggcaa cuccuggcuc acccaccucu cccucuccau gaaccccguc     3060

gaggacaacg gcgucaagcu ccucugcgag gucaugcgcg agcccuccug ccaccuccag     3120

gaccucgagc ucgucaagug ccaccucacc gccgccugcu gcgagucccu cuccugcguc     3180

aucucccgcu cccgccaccu caagucccuc gaccucaccg acaacgcccu cggcgacggc     3240

ggcgucgccg cccucugcga gggccucaag cagaagaacu ccguccucgc ccgccucggc     3300

cucaaggccu gcggccucac cuccgacugc ugcgaggccc ucucccucgc ccucuccugc     3360

aaccgccacc ucaccucccu caaccucguc cagaacaacu ucucccccaa gggcaugaug     3420

aagcucugcu ccgccuucgc cugccccacc uccaaccucc agaucaucgg ccucuggaag     3480

uggcaguacc ccguccagau ccgcaagcuc cucgaggagg uccagcuccu caagccccgc     3540

gucgucaucg acggcuccug gcacuccuuc gacgaggacg accgcuacug guggaagaac     3600

uga                                                                   3603


<210>  9085
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP5__Homo_sapiens__CCDS12938.1

<400>  9085
augaaggugg ccggcgggcu ggagcucgga gcugcagccc uucugagcgc gucccccaga       60

gcuuugguca ccuuaucuac agguccuacu ugcucaaucc ugcccaaaaa cccgcuauuc      120

ccccagaauc ucaguagcca accuuguauu aagauggaag gcgacaaauc ccugacguuu      180

ucuucguacg ggcuucagug gugccuguau gaguuggaua aggaagaguu ccagaccuuu      240

aaagaacucc ugaagaagaa aucaagcgag aguacaacuu guuccauacc acaguucgag      300

aucgaaaacg ccaauguuga gugccuggca cucuuacugc acgaauacua uggagccucu      360

cuugcuuggg caaccagcau uuccaucuuu gagaacauga auuugaggac acugucagag      420

aaggcccggg acgauaugaa acgccauagu cccgaagacc cugaggcuac caugacugau      480

caaggcccaa gcaaggaaaa agugcccggu auuucucagg ccguacagca ggacuccgcg      540

acagcagccg agaccaagga acaagagauc ucacaggcua uggagcagga aggggccacg      600

gcagcugaga cugaagaaca ggaaauaagc caagccaugg agcaggaggg agcgaccgcc      660

gcagaaacag aggaacaggg ccacggcggg gauacuuggg acuacaagag ucaugugaug      720

accaaauucg cugaggaaga ggauguccga cguucuuuug agaacacagc cgcugacugg      780

ccugaaaugc aaacccuagc cggagcauuc gauuccgaca gaugggguuu uaggccacgg      840

acggugguuc uccacggcaa gagcgggauc ggaaaaucgg cccuggcucg cagaauugug      900

cuuuguuggg cgcagggcgg ucuguaucag gggauguucu cuuacgucuu uuucuugccg      960

gugagggaga ugcagcggaa gaaagaaucc ucaguaacug aguuuaucag ucgcgagugg     1020

cccgauagcc aagcaccugu uacagaaauu augucccgac cagagagacu ccuguucauc     1080

auagacggau ucgacgauuu aggcucugug cugaauaacg acaccaagcu cugcaaagau     1140

ugggccgaaa agcagccccc uuuuacucuu auuaggagcc uguugcggaa gguccuacug     1200

ccagagucau uccucaucgu gacagugcgu gacgucggca ccgaaaaacu gaagagugag     1260

guuguguccc cacgcuaucu ucugguaaga gggauuagcg gagagcagag gauccauuug     1320

cuccuggaac gggguaucgg cgagcaccag aaaacgcaag gguuacgagc uauuaugaau     1380

aaccgcgaac ugcuagauca gugucaggug ccggccgucg gaucucucau augcguggca     1440

cugcagcuuc aagacguugu gggcgaguca gucgccccuu uuaaucagac cuugacaggu     1500

cugcacgcug ccuucguguu ucaucagcuc acucccagag ggguaguuag gcggugucug     1560

aaccuugaag aacgcguggu ccugaagaga uucugcagga uggcagugga gggcgucugg     1620

aaucguaaaa guguguuuga uggagacgau uugaugguuc agggccucgg ggaaagcgag     1680

cugcgggcgu uauuccacau gaacauccug cuaccagacu cccauuguga agaguacuac     1740

accuuuuucc accucucucu gcaagauuuu ugcgcugccc uuuauuacgu guuggaagga     1800

cuggagauug agccugcacu cugcccccug uauguagaaa agacaaagcg aucgauggag     1860

uuaaaacagg ccgguuucca cauccauagc cuguggauga agagauuucu uuucggcuug     1920

gucuccgaag acgugaggcg cccacucgag guucugcuag ggugucccgu gccucuggga     1980

gucaaacaga agcuccugca cuggguguca cuuuugggcc aacagccaaa ugcuacuacc     2040

ccgggugaca cacuggaugc cuuccauugc uuauuugaga cccaggacaa agaguucgua     2100

cggcucgcac ugaacaguuu ucaggaggug uggcuuccca uaaaccaaaa ucuggauuug     2160

auugcuucua gcuucugucu ccagcacugc ccuuaccuga gaaagaucag gguugacguc     2220

aaggggaucu uuccacgcga ugaauccgcc gaggcguguc ccguggugcc ucuauggaug     2280

cgagacaaaa cucugauuga ggagcagugg gaggauuucu gcucaaugcu cggcacgcau     2340

ccacaucugc ggcagcuuga cuugggaagc ucuauccuga cagaacgugc caugaagacc     2400

uuaugugcua aacucagaca ccccacuugc aagauucaaa cccugauguu uaggaacgca     2460

cagauaacac cgggcgucca gcaccuuugg cgcaucguua uggccaaucg gaaccugaga     2520

ucccuaaauc ucgggggaac ccaccugaaa gaggaagaug ugaggauggc uugugaggcc     2580

uugaagcauc cuaagugccu guuagaaagu cuccgacugg acuguugcgg ucuuacucac     2640

gcaugcuauc ugaaaauuag ccagaucuug acaacgucuc caucccucaa gucacugagu     2700

cuagcgggca acaaagugac cgaucaaggg guaaugcccc ugagcgacgc ccuucgcguc     2760

ucgcagugug cucuccagaa gcugaucuug gaggauugcg gaauuacugc cacaggcugu     2820

caaucccugg caucugcuuu agugagcaau cggucacuca cccaccugug ccuuaguaac     2880

aauucccugg guaacgaggg gguuaauuug cucuguagau cuaugaggcu gccucauugc     2940

agccuacagc gucugaugcu uaaccagugu caccucgaca cagccggcug cggauuccug     3000

gcauuggccu uaaugggcaa uuccuggcug acucaucucu cacugagcau gaaccccgug     3060

gaagacaaug gggucaaacu ucugugugag gugaugcgcg aaccaaguug ccacuugcag     3120

gaucuagagc ugguuaagug ucaucucacc gcugcgugcu gcgaaucucu guccugugug     3180

auaagccggu cgagacaccu uaaaucauua gaccugacgg auaacgcccu cggagacggc     3240

gguguagcag cuuugugcga ggggcugaag caaaagaacu cuguccucgc caggcuggga     3300

cuuaaagccu guggccugac cagugauugc ugugaggcuu ugucccuagc acugagcugc     3360

aaucgacacc ucacaucuuu aaaccuggug cagaauaacu uuagcccuaa ggguaugaug     3420

aaacuuuguu ccgccuucgc gugccccacu ucaaaucugc agaucauugg ccucuggaag     3480

uggcaguacc cagugcaaau ccggaaauug cuggaagagg uccagcuccu gaagccgcgc     3540

guugugauug acgggaguug gcauagcuuu gaugaagacg auagauauug guggaagaac     3600

uga                                                                   3603


<210>  9086
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP5__Homo_sapiens__CCDS12938.1

<400>  9086
augaaggugg ccggcggccu ggagcugggc gccgccgccc ugcugagcgc cagccccaga       60

gcccugguga cccugagcac cggccccacc ugcagcaucc ugcccaagaa cccccuguuc      120

ccccagaacc ugagcagcca gcccugcauc aagauggagg gcgacaagag ccugaccuuc      180

agcagcuacg gccugcagug gugccuguac gagcuggaca aggaggaguu ccagaccuuc      240

aaggagcugc ugaagaagaa gagcagcgag agcaccaccu gcagcauccc ccaguucgag      300

aucgagaacg ccaacgugga gugccuggcc cugcugcugc acgaguacua cggcgccagc      360

cuggccuggg ccaccagcau cagcaucuuc gagaacauga accugagaac ccugagcgag      420

aaggccagag acgacaugaa gagacacagc cccgaggacc ccgaggccac caugaccgac      480

cagggcccca gcaaggagaa ggugcccggc aucagccagg ccgugcagca ggacagcgcc      540

accgccgccg agaccaagga gcaggagauc agccaggcca uggagcagga gggcgccacc      600

gccgccgaga ccgaggagca ggagaucagc caggccaugg agcaggaggg cgccaccgcc      660

gccgagaccg aggagcaggg ccacggcggc gacaccuggg acuacaagag ccacgugaug      720

accaaguucg ccgaggagga ggacgugaga agaagcuucg agaacaccgc cgccgacugg      780

cccgagaugc agacccuggc cggcgccuuc gacagcgaca gauggggcuu cagacccaga      840

accguggugc ugcacggcaa gagcggcauc ggcaagagcg cccuggccag aagaaucgug      900

cugugcuggg cccagggcgg ccuguaccag ggcauguuca gcuacguguu cuuccugccc      960

gugagagaga ugcagagaaa gaaggagagc agcgugaccg aguucaucag cagagagugg     1020

cccgacagcc aggcccccgu gaccgagauc augagcagac ccgagagacu gcuguucauc     1080

aucgacggcu ucgacgaccu gggcagcgug cugaacaacg acaccaagcu gugcaaggac     1140

ugggccgaga agcagccccc cuucacccug aucagaagcc ugcugagaaa ggugcugcug     1200

cccgagagcu uccugaucgu gaccgugaga gacgugggca ccgagaagcu gaagagcgag     1260

guggugagcc ccagauaccu gcuggugaga ggcaucagcg gcgagcagag aauccaccug     1320

cugcuggaga gaggcaucgg cgagcaccag aagacccagg gccugagagc caucaugaac     1380

aacagagagc ugcuggacca gugccaggug cccgccgugg gcagccugau cugcguggcc     1440

cugcagcugc aggacguggu gggcgagagc guggcccccu ucaaccagac ccugaccggc     1500

cugcacgccg ccuucguguu ccaccagcug acccccagag gcguggugag aagaugccug     1560

aaccuggagg agagaguggu gcugaagaga uucugcagaa uggccgugga gggcgugugg     1620

aacagaaaga gcguguucga cggcgacgac cugauggugc agggccuggg cgagagcgag     1680

cugagagccc uguuccacau gaacauccug cugcccgaca gccacugcga ggaguacuac     1740

accuucuucc accugagccu gcaggacuuc ugcgccgccc uguacuacgu gcuggagggc     1800

cuggagaucg agcccgcccu gugcccccug uacguggaga agaccaagag aagcauggag     1860

cugaagcagg ccggcuucca cauccacagc cuguggauga agagauuccu guucggccug     1920

gugagcgagg acgugagaag accccuggag gugcugcugg gcugccccgu gccccugggc     1980

gugaagcaga agcugcugca cugggugagc cugcugggcc agcagcccaa cgccaccacc     2040

cccggcgaca cccuggacgc cuuccacugc cuguucgaga cccaggacaa ggaguucgug     2100

agacuggccc ugaacagcuu ccaggaggug uggcugccca ucaaccagaa ccuggaccug     2160

aucgccagca gcuucugccu gcagcacugc cccuaccuga gaaagaucag aguggacgug     2220

aagggcaucu uccccagaga cgagagcgcc gaggccugcc ccguggugcc ccuguggaug     2280

agagacaaga cccugaucga ggagcagugg gaggacuucu gcagcaugcu gggcacccac     2340

ccccaccuga gacagcugga ccugggcagc agcauccuga ccgagagagc caugaagacc     2400

cugugcgcca agcugagaca ccccaccugc aagauccaga cccugauguu cagaaacgcc     2460

cagaucaccc ccggcgugca gcaccugugg agaaucguga uggccaacag aaaccugaga     2520

agccugaacc ugggcggcac ccaccugaag gaggaggacg ugagaauggc cugcgaggcc     2580

cugaagcacc ccaagugccu gcuggagagc cugagacugg acugcugcgg ccugacccac     2640

gccugcuacc ugaagaucag ccagauccug accaccagcc ccagccugaa gagccugagc     2700

cuggccggca acaaggugac cgaccagggc gugaugcccc ugagcgacgc ccugagagug     2760

agccagugcg cccugcagaa gcugauccug gaggacugcg gcaucaccgc caccggcugc     2820

cagagccugg ccagcgcccu ggugagcaac agaagccuga cccaccugug ccugagcaac     2880

aacagccugg gcaacgaggg cgugaaccug cugugcagaa gcaugagacu gccccacugc     2940

agccugcaga gacugaugcu gaaccagugc caccuggaca ccgccggcug cggcuuccug     3000

gcccuggccc ugaugggcaa cagcuggcug acccaccuga gccugagcau gaaccccgug     3060

gaggacaacg gcgugaagcu gcugugcgag gugaugagag agcccagcug ccaccugcag     3120

gaccuggagc uggugaagug ccaccugacc gccgccugcu gcgagagccu gagcugcgug     3180

aucagcagaa gcagacaccu gaagagccug gaccugaccg acaacgcccu gggcgacggc     3240

ggcguggccg cccugugcga gggccugaag cagaagaaca gcgugcuggc cagacugggc     3300

cugaaggccu gcggccugac cagcgacugc ugcgaggccc ugagccuggc ccugagcugc     3360

aacagacacc ugaccagccu gaaccuggug cagaacaacu ucagccccaa gggcaugaug     3420

aagcugugca gcgccuucgc cugccccacc agcaaccugc agaucaucgg ccuguggaag     3480

uggcaguacc ccgugcagau cagaaagcug cuggaggagg ugcagcugcu gaagcccaga     3540

guggugaucg acggcagcug gcacagcuuc gacgaggacg acagauacug guggaagaac     3600

uga                                                                   3603


<210>  9087
<211>  3603
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP5__Homo_sapiens__CCDS12938.1

<400>  9087
augaaggugg ccggcgggcu ggagcucgga gcugccgcgc ugcuuagcgc uucccccaga       60

gcccugguca cccucucuac aggcccuacg ugcagcaucc ugccgaaaaa cccccuuuuc      120

ccucagaauc uguccucuca acccuguauu aagauggaag gggacaaaag ccucaccuuu      180

uccucuuacg gacugcagug gugccuguau gagcucgaua aggaagaguu ccagacauuu      240

aaagaacugc uuaagaagaa aagcuccgag agcaccacau guucuauccc ucaguucgag      300

auugaaaacg ccaauguuga gugccuggcu cuccugcuuc acgaauacua uggcgccucc      360

cuggcuuggg ccaccagcau cucuauuuuu gagaacauga aucuccggac acuguccgag      420

aaggcgcgcg acgauaugaa aagacauagc cccgaagacc cugaggccac caugacggau      480

caagggccgu cuaaggaaaa agugcccgga aucucccagg cugugcagca ggacagcgcc      540

accgcugccg agacaaagga acaagagauc ucccaggcga uggagcagga aggcgccacc      600

gcugccgaga cagaagaaca ggaaauuucu caagcuaugg agcaggaggg cgccaccgcc      660

gcugaaacgg aggaacaggg gcacggaggc gauacauggg acuacaagag ccaugucaug      720

accaaauucg cggaggaaga ggaugugcgg cgcuccuuug agaacacagc cgcugacugg      780

ccugaaaugc aaacccuggc cggggccuuc gauagcgaca gauggggauu ucggccccgc      840

accguugugc uccacggcaa gucugggauc ggaaaauccg cucuggccag acggauuguc      900

cuuuguuggg cgcagggcgg ccuguaucag gggauguuca gcuacguguu uuuccucccu      960

guucgcgaga ugcagagaaa gaaagaaucu agcgugacag aguuuaucuc ccgggagugg     1020

cccgauucuc aagcuccggu cacggaaauu augagccgcc cugagagacu gcuuuucauc     1080

auugacggau ucgacgaucu gggcuccgug cucaauaacg acaccaagcu gugcaaagau     1140

ugggccgaaa agcagccccc uuuuacacug auccggagcc uccugcgcaa ggugcuucug     1200

cccgagucuu uccucaucgu caccguuaga gacgugggga cagaaaaacu gaaguccgag     1260

guggucagcc cccgguaucu ucuggugaga ggaauuucug gcgagcagcg cauccaucuc     1320

cugcuggaac gggggauugg agagcaccag aaaacccaag gccucagagc caucaugaau     1380

aaccgcgaac ugcuugauca gugucagguu ccugcugugg gcucccugau uugcgucgcc     1440

cuccagcugc aagacguggu uggggagagc guggcuccgu uuaaucagac gcugacagga     1500

cuucacgccg cguucgucuu ucaucagcuc acaccccggg gcguggucag acgcugucug     1560

aaccuggaag aacggguggu ucucaagaga uucugccgca uggccgugga gggggucugg     1620

aaucggaaau ccguguuuga uggagacgau cugaugguuc agggccuugg ggaaucugag     1680

cugagagcuc ucuuccacau gaacauccug cugccugaca gccauuguga agaguacuac     1740

accuuuuucc accuuucccu ccaagauuuu ugcgccgcuc uguauuacgu gcuggaaggc     1800

cucgagaucg agcccgcccu gugcccucuu uaugucgaaa agaccaagcg cucuauggag     1860

cugaaacagg cgggauucca cauucauagc cucuggauga agcgguuucu guucggccug     1920

guguccgaag acgugagacg gccccuugag guucuccugg gguguccggu cccucuggga     1980

gugaaacaga agcuccugca cugggugagc cuucugggcc aacagcccaa ugccaccaca     2040

ccuggggaca cgcucgaugc uuuccauugc cuguuugaga cccaggacaa agaguucguc     2100

cgccuggccc uuaacucuuu ucaggaggug uggcucccca ucaaccaaaa ucuggaucug     2160

auugcuucca gcuucugucu ccagcacugc ccuuaccuga gaaagauccg gguugacgug     2220

aagggaauuu uucccagaga ugaaucugcc gaggccuguc cggucgugcc ucuuuggaug     2280

cgcgacaaaa cacugaucga ggagcagugg gaggauuucu gcuccaugcu cggcacccau     2340

ccccaucugc ggcagcugga ccuugggagc ucuauccuga cagaaagagc uaugaagacc     2400

cucugugcga aacugcgcca ccccacgugc aagauucaaa cccucauguu uagaaacgcc     2460

cagaucacac cuggcguuca gcaccugugg cggauuguga uggcuaaucg caaccuuaga     2520

agccugaauc ucggaggcac ccaccugaaa gaggaagaug uccggauggc cugugaggcc     2580

cugaagcauc cgaagugccu ucuggaaucc cuccgccugg acuguugcgg gcucacacac     2640

gcuugcuauc ugaaaaucag ccagauucuu accacgucuc ccucccucaa gagccugucc     2700

cuggccggaa acaaagugac agaucaaggc guuaugccuc ugucugacgc gcuuagagug     2760

agccagugug cucugcagaa gcucauccug gaggauugcg ggauuaccgc cacaggaugu     2820

caaucccucg ccucugcucu ggucagcaau cggucccuua cccaccugug ccugucuaac     2880

aauagccucg gcaacgaggg ggugaaucug cuuugucgcu ccaugagacu gccccauugc     2940

agccuccagc ggcugaugcu caaccagugu caccuggaca ccgccggcug cggauuccuu     3000

gcgcuggcuc ugaugggcaa uucuuggcuc acacaucugu cccuuagcau gaacccugug     3060

gaagacaaug gggucaaacu gcucugugag guuaugcgcg aacccucuug ccaucugcag     3120

gaucucgagc uggugaagug ucaccuuacg gccgccugcu gcgaaucccu gagcugugug     3180

aucucuagau cccggcaccu gaaaagccuc gaccugaccg auaacgcucu uggagacggc     3240

ggggucgccg cucugugcga gggacucaag caaaagaacu ccgugcuggc cagacucggc     3300

cugaaagcgu gugggcuuac aagcgauugc ugugaggccc ugucucuggc ucucagcugc     3360

aaucgccacc ugaccucccu uaaccugguu cagaauaacu uuucuccuaa gggcaugaug     3420

aaacucugua gcgccuucgc uugccccaca uccaaucugc agaucauugg acuguggaag     3480

uggcaguacc cggugcaaau ccggaaacuc cuugaagagg uccagcugcu gaagccuaga     3540

gugguuauug acggcucuug gcauagcuuu gaugaagacg aucgcuauug guggaagaac     3600

uga                                                                   3603


<210>  9088
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP6__Homo_sapiens__P59044

<400>  9088

Met Asp Gln Pro Glu Ala Pro Cys Ser Ser Thr Gly Pro Arg Leu Ala 
1               5                   10                  15      


Val Ala Arg Glu Leu Leu Leu Ala Ala Leu Glu Glu Leu Ser Gln Glu 
            20                  25                  30          


Gln Leu Lys Arg Phe Arg His Lys Leu Arg Asp Val Gly Pro Asp Gly 
        35                  40                  45              


Arg Ser Ile Pro Trp Gly Arg Leu Glu Arg Ala Asp Ala Val Asp Leu 
    50                  55                  60                  


Ala Glu Gln Leu Ala Gln Phe Tyr Gly Pro Glu Pro Ala Leu Glu Val 
65                  70                  75                  80  


Ala Arg Lys Thr Leu Lys Arg Ala Asp Ala Arg Asp Val Ala Ala Gln 
                85                  90                  95      


Leu Gln Glu Arg Arg Leu Gln Arg Leu Gly Leu Gly Ser Gly Thr Leu 
            100                 105                 110         


Leu Ser Val Ser Glu Tyr Lys Lys Lys Tyr Arg Glu His Val Leu Gln 
        115                 120                 125             


Leu His Ala Arg Val Lys Glu Arg Asn Ala Arg Ser Val Lys Ile Thr 
    130                 135                 140                 


Lys Arg Phe Thr Lys Leu Leu Ile Ala Pro Glu Ser Ala Ala Pro Glu 
145                 150                 155                 160 


Glu Ala Met Gly Pro Ala Glu Glu Pro Glu Pro Gly Arg Ala Arg Arg 
                165                 170                 175     


Ser Asp Thr His Thr Phe Asn Arg Leu Phe Arg Arg Asp Glu Glu Gly 
            180                 185                 190         


Arg Arg Pro Leu Thr Val Val Leu Gln Gly Pro Ala Gly Ile Gly Lys 
        195                 200                 205             


Thr Met Ala Ala Lys Lys Ile Leu Tyr Asp Trp Ala Ala Gly Lys Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Val Asp Phe Ala Phe Phe Met Pro Cys Gly Glu Leu 
225                 230                 235                 240 


Leu Glu Arg Pro Gly Thr Arg Ser Leu Ala Asp Leu Ile Leu Asp Gln 
                245                 250                 255     


Cys Pro Asp Arg Gly Ala Pro Val Pro Gln Met Leu Ala Gln Pro Gln 
            260                 265                 270         


Arg Leu Leu Phe Ile Leu Asp Gly Ala Asp Glu Leu Pro Ala Leu Gly 
        275                 280                 285             


Gly Pro Glu Ala Ala Pro Cys Thr Asp Pro Phe Glu Ala Ala Ser Gly 
    290                 295                 300                 


Ala Arg Val Leu Gly Gly Leu Leu Ser Lys Ala Leu Leu Pro Thr Ala 
305                 310                 315                 320 


Leu Leu Leu Val Thr Thr Arg Ala Ala Ala Pro Gly Arg Leu Gln Gly 
                325                 330                 335     


Arg Leu Cys Ser Pro Gln Cys Ala Glu Val Arg Gly Phe Ser Asp Lys 
            340                 345                 350         


Asp Lys Lys Lys Tyr Phe Tyr Lys Tyr Phe Arg Asp Glu Arg Arg Ala 
        355                 360                 365             


Glu Arg Ala Tyr Arg Phe Val Lys Glu Asn Glu Thr Leu Phe Ala Leu 
    370                 375                 380                 


Cys Phe Val Pro Phe Val Cys Trp Ile Val Cys Thr Val Leu Arg Gln 
385                 390                 395                 400 


Gln Leu Glu Leu Gly Arg Asp Leu Ser Arg Thr Ser Lys Thr Thr Thr 
                405                 410                 415     


Ser Val Tyr Leu Leu Phe Ile Thr Ser Val Leu Ser Ser Ala Pro Val 
            420                 425                 430         


Ala Asp Gly Pro Arg Leu Gln Gly Asp Leu Arg Asn Leu Cys Arg Leu 
        435                 440                 445             


Ala Arg Glu Gly Val Leu Gly Arg Arg Ala Gln Phe Ala Glu Lys Glu 
    450                 455                 460                 


Leu Glu Gln Leu Glu Leu Arg Gly Ser Lys Val Gln Thr Leu Phe Leu 
465                 470                 475                 480 


Ser Lys Lys Glu Leu Pro Gly Val Leu Glu Thr Glu Val Thr Tyr Gln 
                485                 490                 495     


Phe Ile Asp Gln Ser Phe Gln Glu Phe Leu Ala Ala Leu Ser Tyr Leu 
            500                 505                 510         


Leu Glu Asp Gly Gly Val Pro Arg Thr Ala Ala Gly Gly Val Gly Thr 
        515                 520                 525             


Leu Leu Arg Gly Asp Ala Gln Pro His Ser His Leu Val Leu Thr Thr 
    530                 535                 540                 


Arg Phe Leu Phe Gly Leu Leu Ser Ala Glu Arg Met Arg Asp Ile Glu 
545                 550                 555                 560 


Arg His Phe Gly Cys Met Val Ser Glu Arg Val Lys Gln Glu Ala Leu 
                565                 570                 575     


Arg Trp Val Gln Gly Gln Gly Gln Gly Cys Pro Gly Val Ala Pro Glu 
            580                 585                 590         


Val Thr Glu Gly Ala Lys Gly Leu Glu Asp Thr Glu Glu Pro Glu Glu 
        595                 600                 605             


Glu Glu Glu Gly Glu Glu Pro Asn Tyr Pro Leu Glu Leu Leu Tyr Cys 
    610                 615                 620                 


Leu Tyr Glu Thr Gln Glu Asp Ala Phe Val Arg Gln Ala Leu Cys Arg 
625                 630                 635                 640 


Phe Pro Glu Leu Ala Leu Gln Arg Val Arg Phe Cys Arg Met Asp Val 
                645                 650                 655     


Ala Val Leu Ser Tyr Cys Val Arg Cys Cys Pro Ala Gly Gln Ala Leu 
            660                 665                 670         


Arg Leu Ile Ser Cys Arg Leu Val Ala Ala Gln Glu Lys Lys Lys Lys 
        675                 680                 685             


Ser Leu Gly Lys Arg Leu Gln Ala Ser Leu Gly Gly Gly Ser Ser Ser 
    690                 695                 700                 


Gln Gly Thr Thr Lys Gln Leu Pro Ala Ser Leu Leu His Pro Leu Phe 
705                 710                 715                 720 


Gln Ala Met Thr Asp Pro Leu Cys His Leu Ser Ser Leu Thr Leu Ser 
                725                 730                 735     


His Cys Lys Leu Pro Asp Ala Val Cys Arg Asp Leu Ser Glu Ala Leu 
            740                 745                 750         


Arg Ala Ala Pro Ala Leu Thr Glu Leu Gly Leu Leu His Asn Arg Leu 
        755                 760                 765             


Ser Glu Ala Gly Leu Arg Met Leu Ser Glu Gly Leu Ala Trp Pro Gln 
    770                 775                 780                 


Cys Arg Val Gln Thr Val Arg Val Gln Leu Pro Asp Pro Gln Arg Gly 
785                 790                 795                 800 


Leu Gln Tyr Leu Val Gly Met Leu Arg Gln Ser Pro Ala Leu Thr Thr 
                805                 810                 815     


Leu Asp Leu Ser Gly Cys Gln Leu Pro Ala Pro Met Val Thr Tyr Leu 
            820                 825                 830         


Cys Ala Val Leu Gln His Gln Gly Cys Gly Leu Gln Thr Leu Ser Leu 
        835                 840                 845             


Ala Ser Val Glu Leu Ser Glu Gln Ser Leu Gln Glu Leu Gln Ala Val 
    850                 855                 860                 


Lys Arg Ala Lys Pro Asp Leu Val Ile Thr His Pro Ala Leu Asp Gly 
865                 870                 875                 880 


His Pro Gln Pro Pro Lys Glu Leu Ile Ser Thr Phe 
                885                 890         


<210>  9089
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP6__Homo_sapiens__CCDS7693.1

<400>  9089
auggaccagc cagaggcccc cugcuccagc acggggccgc gccucgcggu ggcccgcgag       60

cugcuccugg cugcgcugga ggaacugagc caagagcagc ugaagcgcuu ccgccacaag      120

cugcgcgacg ugggcccgga cggacgcagc aucccguggg ggcggcugga gcgcgcggac      180

gccguggacc ucgcggagca gcuggcccag uucuacggcc cggagccugc ccuggaggug      240

gcccgcaaga cccucaagag ggcggacgcg cgcgacgugg cggcgcagcu ccaggagcgg      300

cggcugcagc ggcucgggcu cggcuccggg acgcugcucu ccguguccga guacaagaag      360

aaguaccggg agcacgugcu gcagcugcac gcucggguga aggagaggaa cgcccgcucc      420

gugaagauca ccaagcgcuu caccaagcug cucaucgcgc ccgagagcgc cgccccggag      480

gaggcgaugg ggcccgcgga agagccugag ccggggcgcg cgcggcgcuc ggacacgcac      540

acuuucaacc gccucuuccg ccgcgacgag gagggccggc ggccgcugac cguggugcug      600

cagggcccgg cgggcaucgg caagaccaug gcggccaaaa agauccugua cgacugggcg      660

gcgggcaagc uguaccaggg ccagguggac uucgccuucu ucaugcccug cggcgagcug      720

cuggagaggc cgggcacgcg cagccuggcu gaccugaucc uggaccagug ccccgaccgc      780

ggcgcgccgg ugccgcagau gcuggcccag ccgcagcggc ugcucuucau ccuggacggc      840

gcggacgagc ugccggcgcu ggggggcccc gaggccgcgc ccugcacaga ccccuucgag      900

gcggcgagcg gcgcgcgggu gcuaggcggg cugcugagca aggcgcugcu gcccacggcc      960

cuccugcugg ugaccacgcg cgccgccgcc cccgggaggc ugcagggccg ccuguguucc     1020

ccgcagugcg ccgaggugcg cggcuucucc gacaaggaca agaagaagua uuucuacaag     1080

uauuuccggg augagaggag ggccgagcgc gccuaccgcu ucgugaagga gaacgagacg     1140

cuguucgcgc ugugcuucgu gcccuucgug ugcuggaucg ugugcaccgu gcugcgccag     1200

cagcuggagc ucggucggga ccugucgcgc acguccaaga ccaccacguc aguguaccug     1260

cuuuucauca ccagcguucu gagcucggcu ccgguagccg acgggccccg guugcagggc     1320

gaccugcgca aucugugccg ccuggcccgc gagggcgucc ucggacgcag ggcgcaguuu     1380

gccgagaagg aacuggagca acuggagcuu cguggcucca aagugcagac gcuguuucuc     1440

agcaaaaagg agcugccggg cgugcuggag acagagguca ccuaccaguu caucgaccag     1500

agcuuccagg aguuccucgc ggcacugucc uaccugcugg aggacggcgg ggugcccagg     1560

accgcggcug gcggcguugg gacacuccug cguggggacg cccagccgca cagccacuug     1620

gugcucacca cgcgcuuccu cuucggacug cugagcgcgg agcggaugcg cgacaucgag     1680

cgccacuucg gcugcauggu uucagagcgu gugaagcagg aggcccugcg gugggugcag     1740

ggacagggac agggcugccc cggaguggca ccagagguga ccgagggggc caaagggcuc     1800

gaggacaccg aagagccaga ggaggaggag gagggagagg agcccaacua cccacuggag     1860

uugcuguacu gccuguacga gacgcaggag gacgcguuug ugcgccaagc ccugugccgg     1920

uucccggagc uggcgcugca gcgagugcgc uucugccgca uggacguggc uguucugagc     1980

uacugcguga ggugcugccc ugcuggacag gcacugcggc ugaucagcug cagauugguu     2040

gcugcgcagg agaagaagaa gaagagccug gggaagcggc uccaggccag ccuggguggc     2100

ggcagcaguu cucaaggcac cacaaaacaa cugccagccu cccuucuuca uccacucuuu     2160

caggcaauga cugacccacu gugccaucug agcagccuca cgcuguccca cugcaaacuc     2220

ccugacgcgg ucugccgaga ccuuucugag gcccugaggg cagcccccgc acugacggag     2280

cugggccucc uccacaacag gcucagugag gcgggacugc guaugcugag ugagggccua     2340

gccuggccgc agugcagggu gcagacgguc aggguacagc ugccugaccc ccagcgaggg     2400

cuccaguacc ugguggguau gcuucggcag agcccugccc ugaccacccu ggaucucagc     2460

ggcugccaac ugcccgcccc cauggugacc uaccugugug caguccugca gcaccaggga     2520

ugcggccugc agacccucag ucuggccucu guggagcuga gcgagcaguc acuacaggag     2580

cuucaggcug ugaagagagc aaagccggau cuggucauca cacacccagc gcuggacggc     2640

cacccacaac cucccaagga acucaucucg accuucuga                            2679


<210>  9090
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP6__Homo_sapiens__CCDS7693.1

<400>  9090
auggaccagc ccgaggcccc cugcagcucc accggccccc gccuggccgu ggcgcgggag       60

cuccugcugg ccgcccucga ggagcugagc caggagcagc ugaagcgcuu ccggcacaag      120

cuccgcgacg ucgggcccga cggccggucc auccccuggg ggcgccugga gcgggccgac      180

gccguggacc uggcggagca gcucgcccag uucuacggcc cggagcccgc ccuggaggug      240

gcccgcaaga cccugaagcg ggcggacgcc cgcgacgucg ccgcccagcu ccaggagcgg      300

cgccugcagc ggcuggggcu cggcagcggc acgcugcugu ccgugagcga guacaagaag      360

aaguaccgcg agcacgugcu ccagcugcac gcccggguca aggagcgcaa cgcgcggucc      420

gugaagauca ccaagcgcuu caccaagcug cucaucgccc ccgagagcgc cgcccccgag      480

gaggccaugg ggccggcgga ggagcccgag cccggccggg cccgccgguc cgacacccac      540

acguucaacc gccuguuccg ccgggacgag gaggggcgcc ggccccugac cgugguccuc      600

cagggcccgg ccgggaucgg caagaccaug gccgccaaga agauccugua cgacugggcg      660

gccggcaagc uguaccaggg ccagguggac uucgccuucu ucaugcccug cggggagcuc      720

cuggagcgcc ccgggacccg gagccuggcc gaccucaucc uggaccagug ccccgaccgc      780

ggcgccccgg ugccccagau gcuggcgcag ccccagcggc uccuguucau ccuggacggc      840

gccgacgagc uccccgcccu cgggggcccg gaggccgcgc ccugcacgga ccccuucgag      900

gccgccuccg gggcccgcgu ccugggcggg cuccugagca aggcccugcu ccccaccgcg      960

cugcugcucg ugaccacccg ggccgccgcc ccgggccgcc ugcagggccg gcugugcagc     1020

ccccagugcg ccgaggugcg cggguucucc gacaaggaca agaagaagua cuucuacaag     1080

uacuuccggg acgagcgccg ggcggagcgc gccuaccggu ucgucaagga gaacgagacg     1140

cuguucgccc ugugcuucgu gcccuucgug ugcuggaucg ucugcaccgu gcugcgccag     1200

cagcuggagc ucggccggga ccugucccgc accagcaaga ccacgaccuc cguguaccuc     1260

cuguucauca ccagcguccu guccagcgcc cccguggccg acgggccgcg ccugcagggc     1320

gaccuccgga accugugccg ccuggcgcgg gagggggugc ucggccgccg ggcccaguuc     1380

gccgagaagg agcuggagca gcuggagcuc cgcggcagca agguccagac ccuguuccug     1440

uccaagaagg agcuccccgg ggugcuggag acggagguca ccuaccaguu caucgaccag     1500

agcuuccagg aguuccuggc cgcgcucucc uaccugcugg aggacggcgg ggugccccgg     1560

accgccgccg gcgggguggg cacccuccug cgcggcgacg cccagccgca cagccaccug     1620

guccucacga cccgguuccu guucgggcug cucuccgccg agcgcaugcg ggacaucgag     1680

cgccacuucg gcugcauggu gagcgagcgg gugaagcagg aggcgcugcg cuggguccag     1740

gggcagggcc agggcugccc cgggguggcc cccgagguga ccgagggcgc caaggggcug     1800

gaggacaccg aggagcccga ggaggaggag gagggcgagg agccgaacua cccccucgag     1860

cugcuguacu gccucuacga gacgcaggag gacgccuucg uccggcaggc ccugugccgc     1920

uuccccgagc uggcgcucca gcgggugcgc uucugccgga uggacguggc cguccugucc     1980

uacugcgugc gcugcugccc cgccgggcag gcccugcggc ucaucagcug ccgccuggug     2040

gccgcgcagg agaagaagaa gaagucccug ggcaagcgcc uccaggccag ccugggcggg     2100

ggcuccagcu cccaggggac caccaagcag cugccggcca gccuccugca cccccuguuc     2160

caggccauga ccgacccccu cugccaccug uccagccuga cgcucuccca cugcaagcug     2220

cccgacgcgg ucugccggga ccugagcgag gcccuccgcg ccgccccggc ccugaccgag     2280

cugggccucc ugcacaaccg gcuguccgag gcggggcucc gcaugcugag cgagggccug     2340

gccuggcccc agugccgggu gcagaccgug cgcguccagc uccccgaccc ccagcggggc     2400

cugcaguacc ugguggggau gcuccgccag agcccggccc ugaccacgcu ggaccucucc     2460

ggcugccagc ugcccgcccc cauggugacc uaccugugcg ccguccucca gcaccagggg     2520

ugcggccugc agacccugag ccucgcgucc guggagcuga gcgagcaguc ccugcaggag     2580

cuccaggccg ugaagcgggc caagcccgac cuggucauca cccacccggc ccuggacggg     2640

cacccccagc cgcccaagga gcucaucagc accuucuga                            2679


<210>  9091
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP6__Homo_sapiens__CCDS7693.1

<400>  9091
auggaccagc ccgaggcccc cugcuccucc accggccccc gccucgccgu cgcccgcgag       60

cuccuccucg ccgcccucga ggagcucucc caggagcagc ucaagcgcuu ccgccacaag      120

cuccgcgacg ucggccccga cggccgcucc auccccuggg gccgccucga gcgcgccgac      180

gccgucgacc ucgccgagca gcucgcccag uucuacggcc ccgagcccgc ccucgagguc      240

gcccgcaaga cccucaagcg cgccgacgcc cgcgacgucg ccgcccagcu ccaggagcgc      300

cgccuccagc gccucggccu cggcuccggc acccuccucu ccgucuccga guacaagaag      360

aaguaccgcg agcacguccu ccagcuccac gcccgcguca aggagcgcaa cgcccgcucc      420

gucaagauca ccaagcgcuu caccaagcuc cucaucgccc ccgaguccgc cgcccccgag      480

gaggccaugg gccccgccga ggagcccgag cccggccgcg cccgccgcuc cgacacccac      540

accuucaacc gccucuuccg ccgcgacgag gagggccgcc gcccccucac cgucguccuc      600

cagggccccg ccggcaucgg caagaccaug gccgccaaga agauccucua cgacugggcc      660

gccggcaagc ucuaccaggg ccaggucgac uucgccuucu ucaugcccug cggcgagcuc      720

cucgagcgcc ccggcacccg cucccucgcc gaccucaucc ucgaccagug ccccgaccgc      780

ggcgcccccg ucccccagau gcucgcccag ccccagcgcc uccucuucau ccucgacggc      840

gccgacgagc uccccgcccu cggcggcccc gaggccgccc ccugcaccga ccccuucgag      900

gccgccuccg gcgcccgcgu ccucggcggc cuccucucca aggcccuccu ccccaccgcc      960

cuccuccucg ucaccacccg cgccgccgcc cccggccgcc uccagggccg ccucugcucc     1020

ccccagugcg ccgagguccg cggcuucucc gacaaggaca agaagaagua cuucuacaag     1080

uacuuccgcg acgagcgccg cgccgagcgc gccuaccgcu ucgucaagga gaacgagacc     1140

cucuucgccc ucugcuucgu ccccuucguc ugcuggaucg ucugcaccgu ccuccgccag     1200

cagcucgagc ucggccgcga ccucucccgc accuccaaga ccaccaccuc cgucuaccuc     1260

cucuucauca ccuccguccu cuccuccgcc cccgucgccg acggcccccg ccuccagggc     1320

gaccuccgca accucugccg ccucgcccgc gagggcgucc ucggccgccg cgcccaguuc     1380

gccgagaagg agcucgagca gcucgagcuc cgcggcucca agguccagac ccucuuccuc     1440

uccaagaagg agcuccccgg cguccucgag accgagguca ccuaccaguu caucgaccag     1500

uccuuccagg aguuccucgc cgcccucucc uaccuccucg aggacggcgg cgucccccgc     1560

accgccgccg gcggcgucgg cacccuccuc cgcggcgacg cccagcccca cucccaccuc     1620

guccucacca cccgcuuccu cuucggccuc cucuccgccg agcgcaugcg cgacaucgag     1680

cgccacuucg gcugcauggu cuccgagcgc gucaagcagg aggcccuccg cuggguccag     1740

ggccagggcc agggcugccc cggcgucgcc cccgagguca ccgagggcgc caagggccuc     1800

gaggacaccg aggagcccga ggaggaggag gagggcgagg agcccaacua cccccucgag     1860

cuccucuacu gccucuacga gacccaggag gacgccuucg uccgccaggc ccucugccgc     1920

uuccccgagc ucgcccucca gcgcguccgc uucugccgca uggacgucgc cguccucucc     1980

uacugcgucc gcugcugccc cgccggccag gcccuccgcc ucaucuccug ccgccucguc     2040

gccgcccagg agaagaagaa gaagucccuc ggcaagcgcc uccaggccuc ccucggcggc     2100

ggcuccuccu cccagggcac caccaagcag cuccccgccu cccuccucca cccccucuuc     2160

caggccauga ccgacccccu cugccaccuc uccucccuca cccucuccca cugcaagcuc     2220

cccgacgccg ucugccgcga ccucuccgag gcccuccgcg ccgcccccgc ccucaccgag     2280

cucggccucc uccacaaccg ccucuccgag gccggccucc gcaugcucuc cgagggccuc     2340

gccuggcccc agugccgcgu ccagaccguc cgcguccagc uccccgaccc ccagcgcggc     2400

cuccaguacc ucgucggcau gcuccgccag ucccccgccc ucaccacccu cgaccucucc     2460

ggcugccagc uccccgcccc cauggucacc uaccucugcg ccguccucca gcaccagggc     2520

ugcggccucc agacccucuc ccucgccucc gucgagcucu ccgagcaguc ccuccaggag     2580

cuccaggccg ucaagcgcgc caagcccgac cucgucauca cccaccccgc ccucgacggc     2640

cacccccagc cccccaagga gcucaucucc accuucuga                            2679


<210>  9092
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP6__Homo_sapiens__CCDS7693.1

<400>  9092
auggaccagc ccgaggcccc uugcagcucc accggcccaa gacuggcugu ggcaagggaa       60

cuccuucugg ccgcguugga ggaauuaucu caagagcagc ugaagcgguu ccgccacaaa      120

cuacgagaug ucgggccgga cggacguuca auccccuggg guagacucga aagggcugau      180

gccguugacc uggcagagca gcuugcccag uuuuacggcc cugagccagc ucuggaagug      240

gcacggaaga cauugaaacg cgccgaugcu agagacguag ccgcgcaacu ccaggagagg      300

cggcugcagc gccuggggcu cggaaguggc acuuuacuga gcguguccga auauaagaaa      360

aaguaccgag agcauguccu ucaguugcac gcaagaguga aggagaggaa cgcccggucu      420

guuaaaauua cgaagcguuu caccaaacug cuaauagcuc ccgaaucggc cgcaccugag      480

gaagcuaugg guccagccga ggaacccgag ccugggcgcg cgagaagguc agauacacau      540

acuuuuaauc gguuguuccg acgcgacgag gaaggaagaa ggccacugac cgugguccuu      600

caaggcccgg ccggcaucgg gaagacaaug gcagcuaaaa agauucugua ugauugggcc      660

gcuggaaagu uguaccaggg ucagguggac uuugccuucu uuaugcccug uggcgagcuc      720

cuggaacggc cugggacccg cagcuuagca gaucugaucc ucgaccagug cccagauaga      780

ggagcccccg uaccucaaau gcuugcucag ccacagaggc uguuguucau ucuagacggc      840

gcggacgagc ugcccgcacu cggugggccg gaagccgcuc cuuguacuga ucccuuugag      900

gccgcaagug gagcccgugu ucugggcggc cuucugucca aagcucuccu cccaacagcc      960

cuguuacugg ugaccacgcg ggcagcggcu ccugggcgac uacaaggaag acucugcucu     1020

ccccagugug ccgaggucag ggguuucagc gacaaggaua aaaagaaaua uuuuuacaag     1080

uauuuccgcg acgaacggag agcagagagg gccuaccgcu uugugaaaga aaacgagacu     1140

cuguucgcuc uuugcuucgu gccauuuguc uguuggaucg uuugcaccgu guugcgacag     1200

cagcuggaac ucggccggga ucugucccgu acaucaaaga cuaccacaag uguauaccuu     1260

cuguucauaa ccagcguguu gucuuccgcc cccgucgcag acgggccuag acuccaagga     1320

gaucugagga auuuaugucg ccuggcucgg gagggcgugc uagguagaag ggcccaguuu     1380

gcggagaagg aacucgagca gcuggaacuu cgagggucaa aaguucagac guuguuccug     1440

agcaagaaag agcucccagg cgugcuggag acugaaguca cauaucaauu uaucgaccag     1500

aguuuccagg aguuuuuagc cgcucugucu uaccuuuugg aagauggagg cgugccgcgc     1560

accgcagccg ggggaguagg uacucuccug cggggcgacg cucagcccca cucccaucua     1620

guucugacaa ccagauuccu cuuugggcug cuuagcgccg agaggaugcg ugauauugaa     1680

cgccacuucg gaugcauggu gucggagcgg gucaagcaag aggcauugag augggugcag     1740

ggccaggguc aggggugucc uggcgucgcg ccagaaguga cggagggagc caaaggccug     1800

gaagacaccg aggaacccga ggaggaagag gaaggggagg aaccuaacua uccauuagag     1860

cuccuguacu gccuuuauga gacacaagaa gacgcuuuug uuaggcaggc ccugugccga     1920

uuccccgagu uggcacucca gcgggugcgc uuuuguagaa uggauguagc uguccugucu     1980

uacugcguga gguguugccc ggccggacaa gcacuacggc ugaucuccug ucgacucguu     2040

gccgcucagg aaaagaagaa aaagucacug gguaaaagac uucaggcgag uuugggcggg     2100

ggaagcuccu cucagggcac uaccaagcaa cugccugcca gcuuacucca cccacuguuc     2160

caggcaauga cagacccccu uugccaucug ucaagucuaa cucucuccca cuguaaacug     2220

ccugaugcug ugugccgcga cuugagcgag gcccugaggg ccgcucccgc auuaaccgag     2280

cucggucugc uucauaaucg ucugucugaa gccggguugc ggaugcucuc agagggccug     2340

gcguggccac aguguagagu ccagacagug aggguacaac uaccugaucc ccagcgcgga     2400

cugcaguauc uugugggcau gcuccgacag aguccagcuc ugaccacuuu ggaccugagc     2460

gggugccaau uaccggcccc uaugguuacg uaccucugug caguccugca gcaccaggga     2520

ugcggccuuc aaacacuguc cuuggccucu guggaacucu cggagcagag ccugcaggaa     2580

cuacaggcug ugaagagagc aaagcccgau cuggucauua cccacccagc ccuugacggu     2640

cauccccaac cuccaaaaga gcucaucucc acuuucuga                            2679


<210>  9093
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP6__Homo_sapiens__CCDS7693.1

<400>  9093
auggaccagc ccgaggcccc cugcagcagc accggcccca gacuggccgu ggccagagag       60

cugcugcugg ccgcccugga ggagcugagc caggagcagc ugaagagauu cagacacaag      120

cugagagacg ugggccccga cggcagaagc auccccuggg gcagacugga gagagccgac      180

gccguggacc uggccgagca gcuggcccag uucuacggcc ccgagcccgc ccuggaggug      240

gccagaaaga cccugaagag agccgacgcc agagacgugg ccgcccagcu gcaggagaga      300

agacugcaga gacugggccu gggcagcggc acccugcuga gcgugagcga guacaagaag      360

aaguacagag agcacgugcu gcagcugcac gccagaguga aggagagaaa cgccagaagc      420

gugaagauca ccaagagauu caccaagcug cugaucgccc ccgagagcgc cgcccccgag      480

gaggccaugg gccccgccga ggagcccgag cccggcagag ccagaagaag cgacacccac      540

accuucaaca gacuguucag aagagacgag gagggcagaa gaccccugac cguggugcug      600

cagggccccg ccggcaucgg caagaccaug gccgccaaga agauccugua cgacugggcc      660

gccggcaagc uguaccaggg ccagguggac uucgccuucu ucaugcccug cggcgagcug      720

cuggagagac ccggcaccag aagccuggcc gaccugaucc uggaccagug ccccgacaga      780

ggcgcccccg ugccccagau gcuggcccag ccccagagac ugcuguucau ccuggacggc      840

gccgacgagc ugcccgcccu gggcggcccc gaggccgccc ccugcaccga ccccuucgag      900

gccgccagcg gcgccagagu gcugggcggc cugcugagca aggcccugcu gcccaccgcc      960

cugcugcugg ugaccaccag agccgccgcc cccggcagac ugcagggcag acugugcagc     1020

ccccagugcg ccgaggugag aggcuucagc gacaaggaca agaagaagua cuucuacaag     1080

uacuucagag acgagagaag agccgagaga gccuacagau ucgugaagga gaacgagacc     1140

cuguucgccc ugugcuucgu gcccuucgug ugcuggaucg ugugcaccgu gcugagacag     1200

cagcuggagc ugggcagaga ccugagcaga accagcaaga ccaccaccag cguguaccug     1260

cuguucauca ccagcgugcu gagcagcgcc cccguggccg acggccccag acugcagggc     1320

gaccugagaa accugugcag acuggccaga gagggcgugc ugggcagaag agcccaguuc     1380

gccgagaagg agcuggagca gcuggagcug agaggcagca aggugcagac ccuguuccug     1440

agcaagaagg agcugcccgg cgugcuggag accgagguga ccuaccaguu caucgaccag     1500

agcuuccagg aguuccuggc cgcccugagc uaccugcugg aggacggcgg cgugcccaga     1560

accgccgccg gcggcguggg cacccugcug agaggcgacg cccagcccca cagccaccug     1620

gugcugacca ccagauuccu guucggccug cugagcgccg agagaaugag agacaucgag     1680

agacacuucg gcugcauggu gagcgagaga gugaagcagg aggcccugag augggugcag     1740

ggccagggcc agggcugccc cggcguggcc cccgagguga ccgagggcgc caagggccug     1800

gaggacaccg aggagcccga ggaggaggag gagggcgagg agcccaacua cccccuggag     1860

cugcuguacu gccuguacga gacccaggag gacgccuucg ugagacaggc ccugugcaga     1920

uuccccgagc uggcccugca gagagugaga uucugcagaa uggacguggc cgugcugagc     1980

uacugcguga gaugcugccc cgccggccag gcccugagac ugaucagcug cagacuggug     2040

gccgcccagg agaagaagaa gaagagccug ggcaagagac ugcaggccag ccugggcggc     2100

ggcagcagca gccagggcac caccaagcag cugcccgcca gccugcugca cccccuguuc     2160

caggccauga ccgacccccu gugccaccug agcagccuga cccugagcca cugcaagcug     2220

cccgacgccg ugugcagaga ccugagcgag gcccugagag ccgcccccgc ccugaccgag     2280

cugggccugc ugcacaacag acugagcgag gccggccuga gaaugcugag cgagggccug     2340

gccuggcccc agugcagagu gcagaccgug agagugcagc ugcccgaccc ccagagaggc     2400

cugcaguacc uggugggcau gcugagacag agccccgccc ugaccacccu ggaccugagc     2460

ggcugccagc ugcccgcccc cauggugacc uaccugugcg ccgugcugca gcaccagggc     2520

ugcggccugc agacccugag ccuggccagc guggagcuga gcgagcagag ccugcaggag     2580

cugcaggccg ugaagagagc caagcccgac cuggugauca cccaccccgc ccuggacggc     2640

cacccccagc cccccaagga gcugaucagc accuucuga                            2679


<210>  9094
<211>  2679
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP6__Homo_sapiens__CCDS7693.1

<400>  9094
auggaccagc ccgaggcccc uugcagcucc accggcccga gacuggcugu ggcccgggaa       60

cuccugcuug cggcucugga ggaacucucu caagagcagc ugaagcgcuu cagacacaaa      120

cuucgggaug ucgggcccga cggacgcagc aucccuuggg gcagacugga acgggccgau      180

gccguugacc ucgcugagca gcuggcccag uuuuacgggc ccgagccugc ucuggaagug      240

gcccgcaaga cacucaaaag agcggaugcc cgggacgugg cugcccaacu gcaggagcgc      300

agacuucagc ggcugggacu cggcuccggg acgcugcuuu cugucagcga auauaagaaa      360

aaguaccgcg agcaugugcu gcagcuccac gcuagaguua aggagcggaa cgcccgcucc      420

gugaaaauua ccaagagauu cacaaaacug cugaucgcgc ccgaaucugc cgcuccugag      480

gaagccaugg gaccggcuga ggaacccgag ccuggccggg ccagacgcag cgauacccau      540

acauuuaauc ggcuguucag acgcgacgag gaaggccgga gaccccugac cgucgugcuu      600

caagggccug ccggaauugg caagacaaug gcugcgaaaa agauccugua ugauugggcc      660

gcugggaagc ucuaccaggg acagguugac uuugccuucu uuaugcccug uggcgagcug      720

cuugaacgcc cggggacccg gucccuggcc gaucucauuc uggaccagug cccugauaga      780

ggagcucccg ugccucaaau gcuggcccag ccccagcgcc uccuguucau ccuugacggc      840

gcggacgagc ugcccgcucu cggcgggccu gaagccgccc cguguacgga ucccuuugag      900

gcugccagcg gagcucgggu ccugggcggg cuucugucua aagcccuccu gccuaccgcg      960

cugcuccugg ugacaaccag agccgcugcc cccggacgcc uucaaggccg gcugugcucc     1020

ccucagugug cugaggugag aggguucagc gacaaggaua aaaagaaaua uuuuuacaag     1080

uauuuccggg acgaacgcag agccgagcgg gcguacagau uugucaaaga aaacgagaca     1140

cucuucgccc ugugcuucgu ucccuuugug uguuggaucg ugugcaccgu ccugcgccag     1200

cagcuugaac ucggacggga ucugucuaga acguccaaga caaccacaag cguguaccuc     1260

cucuucauua ccucuguucu guccagcgcu ccgguggccg acggcccucg ccuucaaggc     1320

gaucugagaa aucucugucg gcuggcucgc gagggggucc ugggaagacg ggcccaguuu     1380

gccgagaagg aacuugagca gcucgaacug cgcggcucca aagugcagac ccuguuccuc     1440

ucuaagaaag agcugcccgg gguucuugag acagaaguga cguaucaauu uaucgaccag     1500

agcuuccagg aguuucuggc ugcgcucucc uaccugcugg aagauggagg cgucccuaga     1560

accgccgcug ggggcguggg aacacuucuc cggggcgacg cccagcccca cagccaucug     1620

guccugacca cacgcuuccu cuuugggcug cuuucugccg agagaaugcg ggauauugaa     1680

cgccacuucg gaugcauggu guccgagaga guuaagcaag aggcucugcg gugggugcag     1740

ggccaggggc agggaugucc uggcgucgcc cccgaaguga ccgagggggc gaaaggccuc     1800

gaagacacgg aggaaccgga ggaggaagag gaaggagagg aaccuaacua uccccuggag     1860

cugcuuuacu gccucuauga gacacaagaa gacgcuuuug uuagacaggc ccugugccgc     1920

uuccccgagc uggcccucca gcgggugaga uuuugucgca uggaugucgc ugugcugagc     1980

uacugcgugc gguguugccc ugccggccaa gcgcuuagac ugaucucuug ucgccucguu     2040

gcugcccagg aaaagaagaa aaagagccug gggaaacggc ugcaggccuc ccuuggaggc     2100

gggucuagcu cccagggaac caccaagcaa cugccggcua gccuccugca cccccucuuc     2160

caggccauga cagacccucu gugccaucuu ucuucccuga cccucagcca cuguaaacug     2220

cccgaugcug ucugcagaga ccugucugag gcccuucgcg cggccccugc ucugacagag     2280

cucggccugc uccauaaucg gcuguccgaa gccgggcuua gaaugcugag cgagggccuc     2340

gcuuggcccc agugucgggu gcagacggug cgcguccaac ugccugaucc ccagagagga     2400

cugcaguauc uugugggcau gcugcggcag uccccggccc ucaccacacu ggaccucucu     2460

gggugccaac ugccugcccc caugguuacc uaccuuugug cugugcugca gcaccaggga     2520

ugcggccugc aaacacucag ccuggcgucc gucgaacuuu cugagcagag ccugcaggaa     2580

cuccaggccg ugaagcgcgc uaagccugau cugguuauua cccaccccgc ccucgacggg     2640

cauccgcaac cucccaaaga gcugaucucc acguucuga                            2679


<210>  9095
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP7__Homo_sapiens__Q8WX94

<400>  9095

Met Thr Ser Pro Gln Leu Glu Trp Thr Leu Gln Thr Leu Leu Glu Gln 
1               5                   10                  15      


Leu Asn Glu Asp Glu Leu Lys Ser Phe Lys Ser Leu Leu Trp Ala Phe 
            20                  25                  30          


Pro Leu Glu Asp Val Leu Gln Lys Thr Pro Trp Ser Glu Val Glu Glu 
        35                  40                  45              


Ala Asp Gly Lys Lys Leu Ala Glu Ile Leu Val Asn Thr Ser Ser Glu 
    50                  55                  60                  


Asn Trp Ile Arg Asn Ala Thr Val Asn Ile Leu Glu Glu Met Asn Leu 
65                  70                  75                  80  


Thr Glu Leu Cys Lys Met Ala Lys Ala Glu Met Met Glu Asp Gly Gln 
                85                  90                  95      


Val Gln Glu Ile Asp Asn Pro Glu Leu Gly Asp Ala Glu Glu Asp Ser 
            100                 105                 110         


Glu Leu Ala Lys Pro Gly Glu Lys Glu Gly Trp Arg Asn Ser Met Glu 
        115                 120                 125             


Lys Gln Ser Leu Val Trp Lys Asn Thr Phe Trp Gln Gly Asp Ile Asp 
    130                 135                 140                 


Asn Phe His Asp Asp Val Thr Leu Arg Asn Gln Arg Phe Ile Pro Phe 
145                 150                 155                 160 


Leu Asn Pro Arg Thr Pro Arg Lys Leu Thr Pro Tyr Thr Val Val Leu 
                165                 170                 175     


His Gly Pro Ala Gly Val Gly Lys Thr Thr Leu Ala Lys Lys Cys Met 
            180                 185                 190         


Leu Asp Trp Thr Asp Cys Asn Leu Ser Pro Thr Leu Arg Tyr Ala Phe 
        195                 200                 205             


Tyr Leu Ser Cys Lys Glu Leu Ser Arg Met Gly Pro Cys Ser Phe Ala 
    210                 215                 220                 


Glu Leu Ile Ser Lys Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro Ser 
225                 230                 235                 240 


Ile Leu Ala Gln Ala Gln Arg Ile Leu Phe Val Val Asp Gly Leu Asp 
                245                 250                 255     


Glu Leu Lys Val Pro Pro Gly Ala Leu Ile Gln Asp Ile Cys Gly Asp 
            260                 265                 270         


Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Lys 
        275                 280                 285             


Arg Lys Met Leu Pro Arg Ala Ala Leu Leu Val Thr Thr Arg Pro Arg 
    290                 295                 300                 


Ala Leu Arg Asp Leu Gln Leu Leu Ala Gln Gln Pro Ile Tyr Val Arg 
305                 310                 315                 320 


Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His 
                325                 330                 335     


Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser 
            340                 345                 350         


Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile 
        355                 360                 365             


Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val 
    370                 375                 380                 


Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser 
385                 390                 395                 400 


Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser 
                405                 410                 415     


Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Met Ser Val Phe His Arg 
            420                 425                 430         


Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe 
        435                 440                 445             


Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr 
    450                 455                 460                 


Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr 
465                 470                 475                 480 


Ala Leu Glu Lys Glu Glu Gly Glu Asp Arg Asp Gly His Ala Trp Asp 
                485                 490                 495     


Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Glu Glu Arg Leu Lys Asn 
            500                 505                 510         


Pro Asp Leu Ile Gln Val Gly His Phe Leu Phe Gly Leu Ala Asn Glu 
        515                 520                 525             


Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro 
    530                 535                 540                 


Asp Ile Lys Gln Glu Leu Leu Gln Cys Lys Ala His Leu His Ala Asn 
545                 550                 555                 560 


Lys Pro Leu Ser Val Thr Asp Leu Lys Glu Val Leu Gly Cys Leu Tyr 
                565                 570                 575     


Glu Ser Gln Glu Glu Glu Leu Ala Lys Val Val Val Ala Pro Phe Lys 
            580                 585                 590         


Glu Ile Ser Ile His Leu Thr Asn Thr Ser Glu Val Met His Cys Ser 
        595                 600                 605             


Phe Ser Leu Lys His Cys Gln Asp Leu Gln Lys Leu Ser Leu Gln Val 
    610                 615                 620                 


Ala Lys Gly Val Phe Leu Glu Asn Tyr Met Asp Phe Glu Leu Asp Ile 
625                 630                 635                 640 


Glu Phe Glu Arg Cys Thr Tyr Leu Thr Ile Pro Asn Trp Ala Arg Gln 
                645                 650                 655     


Asp Leu Arg Ser Leu Arg Leu Trp Thr Asp Phe Cys Ser Leu Phe Ser 
            660                 665                 670         


Ser Asn Ser Asn Leu Lys Phe Leu Glu Val Lys Gln Ser Phe Leu Ser 
        675                 680                 685             


Asp Ser Ser Val Arg Ile Leu Cys Asp His Val Thr Arg Ser Thr Cys 
    690                 695                 700                 


His Leu Gln Lys Val Glu Ile Lys Asn Val Thr Pro Asp Thr Ala Tyr 
705                 710                 715                 720 


Arg Asp Phe Cys Leu Ala Phe Ile Gly Lys Lys Thr Leu Thr His Leu 
                725                 730                 735     


Thr Leu Ala Gly His Ile Glu Trp Glu Arg Thr Met Met Leu Met Leu 
            740                 745                 750         


Cys Asp Leu Leu Arg Asn His Lys Cys Asn Leu Gln Tyr Leu Arg Leu 
        755                 760                 765             


Gly Gly His Cys Ala Thr Pro Glu Gln Trp Ala Glu Phe Phe Tyr Val 
    770                 775                 780                 


Leu Lys Ala Asn Gln Ser Leu Lys His Leu Arg Leu Ser Ala Asn Val 
785                 790                 795                 800 


Leu Leu Asp Glu Gly Ala Met Leu Leu Tyr Lys Thr Met Thr Arg Pro 
                805                 810                 815     


Lys His Phe Leu Gln Met Leu Ser Leu Glu Asn Cys Arg Leu Thr Glu 
            820                 825                 830         


Ala Ser Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Lys Lys Leu 
        835                 840                 845             


Thr His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asp Thr Gly Val Lys 
    850                 855                 860                 


Phe Leu Cys Glu Gly Leu Ser Tyr Pro Asp Cys Lys Leu Gln Thr Leu 
865                 870                 875                 880 


Val Leu Gln Gln Cys Ser Ile Thr Lys Leu Gly Cys Arg Tyr Leu Ser 
                885                 890                 895     


Glu Ala Leu Gln Glu Ala Cys Ser Leu Thr Asn Leu Asp Leu Ser Ile 
            900                 905                 910         


Asn Gln Ile Ala Arg Gly Leu Trp Ile Leu Cys Gln Ala Leu Glu Asn 
        915                 920                 925             


Pro Asn Cys Asn Leu Lys His Leu Arg Leu Lys Thr Tyr Glu Thr Asn 
    930                 935                 940                 


Leu Glu Ile Lys Lys Leu Leu Glu Glu Val Lys Glu Lys Asn Pro Lys 
945                 950                 955                 960 


Leu Thr Ile Asp Cys Asn Ala Ser Gly Ala Thr Ala Pro Pro Cys Cys 
                965                 970                 975     


Asp Phe Phe Cys 
            980 


<210>  9096
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP7__Homo_sapiens__AAL69963

<400>  9096
augacaucgc cccagcuaga guggacucug cagacccuuc uggagcagcu gaacgaggau       60

gaauuaaaga guuucaaauc ccuuuuaugg gcuuuucccc ucgaagacgu gcuacagaag      120

accccauggu cugaggugga agaggcugau ggcaagaaac uggcagaaau ucuggucaac      180

accuccucag aaaauuggau aaggaaugcg acugugaaca ucuuggaaga gaugaaucuc      240

acggaauugu guaagauggc aaaggcugag augauggagg acggacaggu gcaagaaaua      300

gauaauccug agcugggaga ugcagaagaa gacucggagu uagcaaagcc aggugaaaag      360

gaaggaugga gaaauucaau ggagaaacag ucuuuggucu ggaagaacac cuuuuggcaa      420

ggagacauug acaauuucca ugacgacguc acucugagaa accaacgguu cauuccauuc      480

uugaauccca gaacacccag gaagcuaaca ccuuacacgg uggugcugca cggccccgca      540

ggcgugggga aaaccacgcu ggccaaaaag uguaugcugg acuggacaga cugcaaccuc      600

agcccgacgc ucagauacgc guucuaccuc agcugcaagg agcucagccg caugggcccc      660

ugcaguuuug cagagcugau cuccaaagac uggccugaau ugcaggauga cauuccaagc      720

auccuagccc aagcacagag aauccuguuc guggucgaug gccuugauga gcugaaaguc      780

ccaccugggg cgcugaucca ggacaucugc ggggacuggg agaagaagaa gccggugccc      840

guccuccugg ggaguuugcu gaagaggaag auguuaccca gggcagccuu gcuggucacc      900

acgcggccca gggcacugag ggaccuccag cuccuggcgc agcagccgau cuacguaagg      960

guggagggcu uccuggagga ggacaggagg gccuauuucc ugagacacuu uggagacgag     1020

gaccaagcca ugcgugccuu ugagcuaaug aggagcaacg cggcccuguu ccagcugggc     1080

ucggcccccg cggugugcug gauugugugc acgacucuga agcugcagau ggagaagggg     1140

gaggacccgg uccccaccug ccucacccgc acggggcugu uccugcguuu ccucugcagc     1200

cgguucccgc agggcgcaca gcugcggggc gcgcugcgga cgcugagccu ccuggccgcg     1260

cagggccugu gggcgcagau guccguguuc caccgagagg accuggaaag gcucggggug     1320

caggaguccg accuccgucu guuccuggac ggagacaucc uccgccagga cagagucucc     1380

aaaggcugcu acuccuucau ccaccucagc uuccagcagu uucucacugc ccuguucuac     1440

gcccuggaga aggaggaggg ggaggacagg gacggccacg ccugggacau cggggacgua     1500

cagaagcugc uuuccggaga agaaagacuc aagaaccccg accugauuca aguaggacac     1560

uucuuauucg gccucgcuaa cgagaagaga gccaaggagu uggaggccac uuuuggcugc     1620

cggaugucac cggacaucaa acaggaauug cugcaaugca aagcacaucu ucaugcaaau     1680

aagcccuuau ccgugaccga ccugaaggag gucuugggcu gccuguauga gucucaggag     1740

gaggagcugg cgaagguggu gguggccccg uucaaggaaa uuucuauuca ccugacaaau     1800

acuucugaag ugaugcauug uuccuucagc cugaagcauu gucaagacuu gcagaaacuc     1860

ucacugcagg uagcaaaggg gguguuccug gagaauuaca uggauuuuga acuggacauu     1920

gaauuugaaa ggugcacuua ccuaaccauu ccgaacuggg cucggcagga ucuucgcucu     1980

cuucgccucu ggacagauuu cugcucucuc uucagcucaa acagcaaccu caaguuucug     2040

gaagugaaac aaagcuuccu gagugacucu ucugugcgga uucuuuguga ccacguaacc     2100

cguagcaccu gucaucugca gaaaguggag auuaaaaacg ucaccccuga caccgcguac     2160

cgggacuucu gucuugcuuu cauugggaag aagacccuca cgcaccugac ccuggcaggg     2220

cacaucgagu gggaacgcac gaugaugcug augcugugug accugcucag aaaucauaaa     2280

ugcaaccugc aguaccugag guugggaggu cacugugcca ccccggagca gugggcugaa     2340

uucuucuaug uccucaaagc caaccagucc cugaagcacc ugcgucucuc agccaaugug     2400

cuccuggaug agggugccau guugcuguac aagaccauga cacgcccaaa acacuuccug     2460

cagauguugu cguuggaaaa cugucgucuu acagaagcca guugcaagga ccuugcugcu     2520

gucuugguug ucagcaagaa gcugacacac cugugcuugg ccaagaaccc cauuggggau     2580

acagggguga aguuucugug ugagggcuug aguuacccug auuguaaacu gcagaccuug     2640

guguuacagc aaugcagcau aaccaagcuu ggcuguagau aucucucaga ggcgcuccaa     2700

gaagccugca gccucacaaa ccuggacuug aguaucaacc agauagcucg uggauugugg     2760

auucucuguc aggcauuaga gaauccaaac uguaaccuaa aacaccuacg guugaagacc     2820

uaugaaacua auuuggaaau caagaagcug uuggaggaag ugaaagaaaa gaaucccaag     2880

cugacuauug auugcaaugc uuccggggca acggcaccuc cgugcuguga cuuuuuuugc     2940

uga                                                                   2943


<210>  9097
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP7__Homo_sapiens__AAL69963

<400>  9097
augaccagcc cccagcugga guggacccuc cagacgcugc uggagcagcu caacgaggac       60

gagcugaagu ccuucaagag ccugcucugg gccuuccccc uggaggacgu gcugcagaag      120

acccccuggu ccgaggucga ggaggccgac ggcaagaagc ucgcggagau ccuggugaac      180

accagcuccg agaacuggau ccgcaacgcc accgugaaca uccuggagga gaugaaccuc      240

acggagcugu gcaagauggc caaggccgag augauggagg acgggcaggu ccaggagauc      300

gacaaccccg agcugggcga cgccgaggag gacagcgagc ucgcgaagcc cggggagaag      360

gagggcuggc ggaacuccau ggagaagcag agccuggugu ggaagaacac cuucuggcag      420

ggggacaucg acaacuucca cgacgacgug acccugcgca accagcgguu caucccguuc      480

cucaaccccc gcacgccccg gaagcugacc cccuacaccg ucgugcugca cggcccggcc      540

ggcgugggga agaccacccu cgccaagaag ugcaugcugg acuggacgga cugcaaccug      600

ucccccaccc uccgcuacgc cuucuaccug agcugcaagg agcugucccg gaugggcccc      660

ugcagcuucg cggagcucau cuccaaggac uggcccgagc ugcaggacga caucccgagc      720

auccuggccc aggcccagcg cauccucuuc gucguggacg ggcuggacga gcugaaggug      780

ccgcccggcg cccucaucca ggacaucugc ggggacuggg agaagaagaa gcccgucccc      840

gugcugcugg gcucccuccu gaagcggaag augcugcccc gcgccgcgcu ccuggugacc      900

acccggcccc gcgcccugcg ggaccuccag cugcuggccc agcagcccau cuacguccgc      960

guggagggcu uccucgagga ggaccggcgc gccuacuucc ugcggcacuu cggggacgag     1020

gaccaggcca ugcgcgcguu cgagcugaug cggagcaacg ccgcccucuu ccagcugggc     1080

uccgccccgg ccgugugcug gaucgucugc acgacccuga agcugcagau ggagaagggg     1140

gaggaccccg ugccgaccug ccucacccgc acgggccugu uccugcgguu ccucugcagc     1200

cgcuuccccc agggcgcgca gcugcgcggg gcccugcgga cccucucccu gcuggccgcc     1260

cagggccucu gggcccagau gagcguguuc caccgcgagg accuggagcg gcuggggguc     1320

caggagagcg accuccgccu guuccuggac ggcgacaucc uccggcagga ccgcgugucc     1380

aaggggugcu acagcuucau ccaccugucc uuccagcagu uccugaccgc gcuguucuac     1440

gcccuggaga aggaggaggg cgaggaccgg gacggccacg ccugggacau cggggacgug     1500

cagaagcugc ucagcggcga ggagcgccug aagaaccccg accugaucca ggucgggcac     1560

uuccucuucg gccuggccaa cgagaagcgg gcgaaggagc uggaggccac cuucgggugc     1620

cgcauguccc ccgacaucaa gcaggagcuc cugcagugca aggcccaccu ccacgccaac     1680

aagccccuca gcgugacgga ccugaaggag guccugggcu gccucuacga gucccaggag     1740

gaggagcugg ccaagguggu ggucgcgccc uucaaggaga ucagcaucca ccugaccaac     1800

accuccgagg ugaugcacug cagcuucucc cucaagcacu gccaggaccu gcagaagcug     1860

agccuccagg uggccaaggg cgucuuccug gagaacuaca uggacuucga gcuggacauc     1920

gaguucgagc ggugcaccua ccucacgauc ccgaacuggg cccgccagga ccugcggucc     1980

cugcgccucu ggaccgacuu cugcagccug uucuccagca acuccaaccu gaaguuccuc     2040

gaggugaagc agagcuuccu guccgacagc agcgugcgga uccugugcga ccacgucacc     2100

cgcuccacgu gccaccucca gaagguggag aucaagaacg ugacccccga caccgccuac     2160

cgggacuucu gccuggccuu caucgggaag aagacccuga cccaccucac gcuggcgggc     2220

cacaucgagu gggagcgcac caugaugcug augcucugcg accugcugcg gaaccacaag     2280

ugcaaccucc aguaccugcg ccucgggggc cacugcgcca cccccgagca gugggccgag     2340

uucuucuacg uccugaaggc caaccagagc cugaagcacc uccgccuguc cgccaacgug     2400

cugcuggacg agggggcgau gcuccuguac aagaccauga cccggccgaa gcacuuccug     2460

cagaugcuca gccuggagaa cugccgccug acggaggccu ccugcaagga ccucgccgcc     2520

gugcuggucg ugagcaagaa gcugacccac cucugccugg cgaagaaccc caucggcgac     2580

accggcguga aguuccugug cgaggggcuc uccuaccccg acugcaagcu gcagacccug     2640

guccuccagc agugcagcau cacgaagcug ggcugccggu accuguccga ggcccuccag     2700

gaggccugca gccugaccaa ccuggaccuc uccaucaacc agaucgcccg cgggcugugg     2760

auccugugcc aggcccucga gaaccccaac ugcaaccuga agcaccuccg gcugaagacc     2820

uacgagacca accuggagau caagaagcug cuggaggagg ugaaggagaa gaacccgaag     2880

cucacgaucg acugcaacgc gagcggcgcc accgccccgc ccugcugcga cuucuucugc     2940

uga                                                                   2943


<210>  9098
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP7__Homo_sapiens__AAL69963

<400>  9098
augaccuccc cccagcucga guggacccuc cagacccucc ucgagcagcu caacgaggac       60

gagcucaagu ccuucaaguc ccuccucugg gccuuccccc ucgaggacgu ccuccagaag      120

acccccuggu ccgaggucga ggaggccgac ggcaagaagc ucgccgagau ccucgucaac      180

accuccuccg agaacuggau ccgcaacgcc accgucaaca uccucgagga gaugaaccuc      240

accgagcucu gcaagauggc caaggccgag augauggagg acggccaggu ccaggagauc      300

gacaaccccg agcucggcga cgccgaggag gacuccgagc ucgccaagcc cggcgagaag      360

gagggcuggc gcaacuccau ggagaagcag ucccucgucu ggaagaacac cuucuggcag      420

ggcgacaucg acaacuucca cgacgacguc acccuccgca accagcgcuu cauccccuuc      480

cucaaccccc gcaccccccg caagcucacc cccuacaccg ucguccucca cggccccgcc      540

ggcgucggca agaccacccu cgccaagaag ugcaugcucg acuggaccga cugcaaccuc      600

ucccccaccc uccgcuacgc cuucuaccuc uccugcaagg agcucucccg caugggcccc      660

ugcuccuucg ccgagcucau cuccaaggac uggcccgagc uccaggacga cauccccucc      720

auccucgccc aggcccagcg cauccucuuc gucgucgacg gccucgacga gcucaagguc      780

ccccccggcg cccucaucca ggacaucugc ggcgacuggg agaagaagaa gcccgucccc      840

guccuccucg gcucccuccu caagcgcaag augcuccccc gcgccgcccu ccucgucacc      900

acccgccccc gcgcccuccg cgaccuccag cuccucgccc agcagcccau cuacguccgc      960

gucgagggcu uccucgagga ggaccgccgc gccuacuucc uccgccacuu cggcgacgag     1020

gaccaggcca ugcgcgccuu cgagcucaug cgcuccaacg ccgcccucuu ccagcucggc     1080

uccgcccccg ccgucugcug gaucgucugc accacccuca agcuccagau ggagaagggc     1140

gaggaccccg uccccaccug ccucacccgc accggccucu uccuccgcuu ccucugcucc     1200

cgcuuccccc agggcgccca gcuccgcggc gcccuccgca cccucucccu ccucgccgcc     1260

cagggccucu gggcccagau guccgucuuc caccgcgagg accucgagcg ccucggcguc     1320

caggaguccg accuccgccu cuuccucgac ggcgacaucc uccgccagga ccgcgucucc     1380

aagggcugcu acuccuucau ccaccucucc uuccagcagu uccucaccgc ccucuucuac     1440

gcccucgaga aggaggaggg cgaggaccgc gacggccacg ccugggacau cggcgacguc     1500

cagaagcucc ucuccggcga ggagcgccuc aagaaccccg accucaucca ggucggccac     1560

uuccucuucg gccucgccaa cgagaagcgc gccaaggagc ucgaggccac cuucggcugc     1620

cgcauguccc ccgacaucaa gcaggagcuc cuccagugca aggcccaccu ccacgccaac     1680

aagccccucu ccgucaccga ccucaaggag guccucggcu gccucuacga gucccaggag     1740

gaggagcucg ccaaggucgu cgucgccccc uucaaggaga ucuccaucca ccucaccaac     1800

accuccgagg ucaugcacug cuccuucucc cucaagcacu gccaggaccu ccagaagcuc     1860

ucccuccagg ucgccaaggg cgucuuccuc gagaacuaca uggacuucga gcucgacauc     1920

gaguucgagc gcugcaccua ccucaccauc cccaacuggg cccgccagga ccuccgcucc     1980

cuccgccucu ggaccgacuu cugcucccuc uucuccucca acuccaaccu caaguuccuc     2040

gaggucaagc aguccuuccu cuccgacucc uccguccgca uccucugcga ccacgucacc     2100

cgcuccaccu gccaccucca gaaggucgag aucaagaacg ucacccccga caccgccuac     2160

cgcgacuucu gccucgccuu caucggcaag aagacccuca cccaccucac ccucgccggc     2220

cacaucgagu gggagcgcac caugaugcuc augcucugcg accuccuccg caaccacaag     2280

ugcaaccucc aguaccuccg ccucggcggc cacugcgcca cccccgagca gugggccgag     2340

uucuucuacg uccucaaggc caaccagucc cucaagcacc uccgccucuc cgccaacguc     2400

cuccucgacg agggcgccau gcuccucuac aagaccauga cccgccccaa gcacuuccuc     2460

cagaugcucu cccucgagaa cugccgccuc accgaggccu ccugcaagga ccucgccgcc     2520

guccucgucg ucuccaagaa gcucacccac cucugccucg ccaagaaccc caucggcgac     2580

accggcguca aguuccucug cgagggccuc uccuaccccg acugcaagcu ccagacccuc     2640

guccuccagc agugcuccau caccaagcuc ggcugccgcu accucuccga ggcccuccag     2700

gaggccugcu cccucaccaa ccucgaccuc uccaucaacc agaucgcccg cggccucugg     2760

auccucugcc aggcccucga gaaccccaac ugcaaccuca agcaccuccg ccucaagacc     2820

uacgagacca accucgagau caagaagcuc cucgaggagg ucaaggagaa gaaccccaag     2880

cucaccaucg acugcaacgc cuccggcgcc accgcccccc ccugcugcga cuucuucugc     2940

uga                                                                   2943


<210>  9099
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP7__Homo_sapiens__AAL69963

<400>  9099
augaccagcc cccagcugga auggacacuc caaacucuuc uggaacaguu gaacgaggac       60

gaauuaaagu ccuucaaauc ucugcuaugg gccuuuccuc ucgaggaugu gcugcagaag      120

acgccauggu cagaagucga ggaggcugac ggcaaaaagc uggcagaaau ccuuguuaau      180

accaguagcg agaacuggau uagaaaugcc acagugaaca uauuggaaga gaugaaucuc      240

acugagcugu gcaaaauggc gaaggcugaa augauggagg augggcaggu acaagaaauc      300

gacaacccgg agcugggaga ugccgaagag gacuccgagc ucgcaaagcc cggugaaaaa      360

gagggcugga gaaauucuau ggaaaagcag ucguuagugu ggaaaaacac cuucuggcag      420

ggggauauug acaauuuuca cgaugacguc acacugcgga accagcgcuu caucccuuuu      480

cuuaauccac gaacuccccg uaaguugacc ccuuacacag ugguucugca uggaccagcc      540

ggcgugggua aaaccacgcu agcuaagaag uguaugcucg auuggacuga cugcaaccug      600

ucacccaccc uuagauaugc auucuaccug agcuguaaag aguugaguag gauggggccu      660

ugcuccuuug ccgaacucau uucuaaggau uggccagagc ugcaagacga caucccgagc      720

auauuagcuc aggcccagcg gauccuguuc gucguggaug gacucgacga gcuuaaagua      780

cccccuggcg cgcugauuca ggauaucugu ggcgacuggg aaaagaaaaa gccaguuccc      840

guguugcuag ggucccugcu caaacgcaag augcugccua gagcagcccu ucuggucaca      900

acuaggccac gggcuuugcg cgaucuccaa cuguuagccc agcagcccau uuaugugcga      960

guggagggau uucuggaaga ggacagaagg gcauacuucc uacggcacuu uggugaugaa     1020

gaccaagcua ugcgugccuu cgagcucaug cgcucaaaug cggcccuguu ucagcuuggc     1080

agugcaccgg cugucugcug gaucguuugu accacauuga agcugcagau ggagaaaggg     1140

gaagauccug ugccaaccug ccucacgaga acuggacugu uccuuagguu ccuguguagc     1200

cgguuucccc agggcgccca auugcgaggu gcucuccgca cacugucuuu acuggccgca     1260

caggggcuau gggcccagau guccguauuc cauagagagg accucgaaag gcugggagug     1320

caggagucag aucuucgguu guuucuggac ggcgacauac uccgccaaga uagagucagc     1380

aagggcugcu auaguuucau ucaccugucu uuucagcagu ucuuaaccgc ucuguuuuac     1440

gcgcuugaga aagaagaggg ggaagacagg gauggacaug caugggacau cggugaugug     1500

cagaaguugc ucuccggcga ggaacgucug aaaaacccug accuaauuca aguugggcac     1560

uuccuguuug gacucgccaa ugagaagcgg gcuaaggagc uggaagccac uuucggcugu     1620

cgaaugagcc ccgauaucaa acaggagcuu uugcagugca aggcacaucu gcacgccaac     1680

aaaccauuau cggugacaga ccucaaggaa guccuggguu gccuuuauga gucucaggaa     1740

gaggagcugg cuaaaguggu aguugccccc uuuaaggaaa ucuccauuca cuugaccaac     1800

acgucagagg ugaugcauug uaguuucagc cucaagcacu gccaagaucu gcagaaacua     1860

ucccugcagg ucgcaaaggg gguguuucuc gaaaauuaca uggacuucga gcuggauaua     1920

gaguucgaaa gauguaccua ccuuacaauc ccuaacuggg cgaggcaaga cuugcgcucu     1980

cugcgguuau ggacugauuu uugcagccuc uucucaagua auuccaaccu gaaauuucuu     2040

gaggucaagc agagcuuccu gucugacuca agugugagga uucuauguga ccacguuacc     2100

aggagcacau gccaucucca gaaaguggaa aucaagaaug uaacuccaga uaccgcuuau     2160

cgcgacuuuu gucuggccuu cauaggcaag aaaacauuga cccaccugac uuuagcagga     2220

cauauugagu gggaacgaac gaugaugcuc augcugugcg aucuucugcg gaaccacaag     2280

uguaauuugc aguaccuccg ucugggcggg cauugcgcca caccggagca augggcugag     2340

uuuuucuaug uccuaaaagc caaccagucc cugaagcacc uuagacucuc ugcaaaugug     2400

cuguuggacg aaggagcuau gcuguuauac aaaaccauga cuaggcccaa gcacuuucuc     2460

cagaugcugu cgcuugagaa cugucgccug accgaagcca gcugcaaaga uuuggcggcc     2520

guucucgugg ucuccaagaa gcugacacau cuaugccugg cuaaaaaucc uaucggugac     2580

accggcguga aguuccuuug ugaggggcuc ucauauccag auugcaaacu gcagacuuug     2640

guauuacaac aguguaguau cacaaagcug ggaugccggu accucucuga agcacugcag     2700

gaggccugua gccuuacgaa ccuggacuug uccauuaauc agaucgcuag aggccuaugg     2760

auucugugcc aagcccucga gaaccccaau uguaaccuga aacaccuuag guuaaagacc     2820

uaugaaacua accuggagau aaagaaacuc uuggaagagg ugaaggagaa aaauccuaag     2880

cugacaaucg auugcaacgc aucaggugcg accgccccac ccuguugcga cuuuuucugu     2940

uga                                                                   2943


<210>  9100
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP7__Homo_sapiens__AAL69963

<400>  9100
augaccagcc cccagcugga guggacccug cagacccugc uggagcagcu gaacgaggac       60

gagcugaaga gcuucaagag ccugcugugg gccuuccccc uggaggacgu gcugcagaag      120

acccccugga gcgaggugga ggaggccgac ggcaagaagc uggccgagau ccuggugaac      180

accagcagcg agaacuggau cagaaacgcc accgugaaca uccuggagga gaugaaccug      240

accgagcugu gcaagauggc caaggccgag augauggagg acggccaggu gcaggagauc      300

gacaaccccg agcugggcga cgccgaggag gacagcgagc uggccaagcc cggcgagaag      360

gagggcugga gaaacagcau ggagaagcag agccuggugu ggaagaacac cuucuggcag      420

ggcgacaucg acaacuucca cgacgacgug acccugagaa accagagauu cauccccuuc      480

cugaacccca gaacccccag aaagcugacc cccuacaccg uggugcugca cggccccgcc      540

ggcgugggca agaccacccu ggccaagaag ugcaugcugg acuggaccga cugcaaccug      600

agccccaccc ugagauacgc cuucuaccug agcugcaagg agcugagcag aaugggcccc      660

ugcagcuucg ccgagcugau cagcaaggac uggcccgagc ugcaggacga cauccccagc      720

auccuggccc aggcccagag aauccuguuc gugguggacg gccuggacga gcugaaggug      780

ccccccggcg cccugaucca ggacaucugc ggcgacuggg agaagaagaa gcccgugccc      840

gugcugcugg gcagccugcu gaagagaaag augcugccca gagccgcccu gcuggugacc      900

accagaccca gagcccugag agaccugcag cugcuggccc agcagcccau cuacgugaga      960

guggagggcu uccuggagga ggacagaaga gccuacuucc ugagacacuu cggcgacgag     1020

gaccaggcca ugagagccuu cgagcugaug agaagcaacg ccgcccuguu ccagcugggc     1080

agcgcccccg ccgugugcug gaucgugugc accacccuga agcugcagau ggagaagggc     1140

gaggaccccg ugcccaccug ccugaccaga accggccugu uccugagauu ccugugcagc     1200

agauuccccc agggcgccca gcugagaggc gcccugagaa cccugagccu gcuggccgcc     1260

cagggccugu gggcccagau gagcguguuc cacagagagg accuggagag acugggcgug     1320

caggagagcg accugagacu guuccuggac ggcgacaucc ugagacagga cagagugagc     1380

aagggcugcu acagcuucau ccaccugagc uuccagcagu uccugaccgc ccuguucuac     1440

gcccuggaga aggaggaggg cgaggacaga gacggccacg ccugggacau cggcgacgug     1500

cagaagcugc ugagcggcga ggagagacug aagaaccccg accugaucca ggugggccac     1560

uuccuguucg gccuggccaa cgagaagaga gccaaggagc uggaggccac cuucggcugc     1620

agaaugagcc ccgacaucaa gcaggagcug cugcagugca aggcccaccu gcacgccaac     1680

aagccccuga gcgugaccga ccugaaggag gugcugggcu gccuguacga gagccaggag     1740

gaggagcugg ccaagguggu gguggccccc uucaaggaga ucagcaucca ccugaccaac     1800

accagcgagg ugaugcacug cagcuucagc cugaagcacu gccaggaccu gcagaagcug     1860

agccugcagg uggccaaggg cguguuccug gagaacuaca uggacuucga gcuggacauc     1920

gaguucgaga gaugcaccua ccugaccauc cccaacuggg ccagacagga ccugagaagc     1980

cugagacugu ggaccgacuu cugcagccug uucagcagca acagcaaccu gaaguuccug     2040

gaggugaagc agagcuuccu gagcgacagc agcgugagaa uccugugcga ccacgugacc     2100

agaagcaccu gccaccugca gaagguggag aucaagaacg ugacccccga caccgccuac     2160

agagacuucu gccuggccuu caucggcaag aagacccuga cccaccugac ccuggccggc     2220

cacaucgagu gggagagaac caugaugcug augcugugcg accugcugag aaaccacaag     2280

ugcaaccugc aguaccugag acugggcggc cacugcgcca cccccgagca gugggccgag     2340

uucuucuacg ugcugaaggc caaccagagc cugaagcacc ugagacugag cgccaacgug     2400

cugcuggacg agggcgccau gcugcuguac aagaccauga ccagacccaa gcacuuccug     2460

cagaugcuga gccuggagaa cugcagacug accgaggcca gcugcaagga ccuggccgcc     2520

gugcuggugg ugagcaagaa gcugacccac cugugccugg ccaagaaccc caucggcgac     2580

accggcguga aguuccugug cgagggccug agcuaccccg acugcaagcu gcagacccug     2640

gugcugcagc agugcagcau caccaagcug ggcugcagau accugagcga ggcccugcag     2700

gaggccugca gccugaccaa ccuggaccug agcaucaacc agaucgccag aggccugugg     2760

auccugugcc aggcccugga gaaccccaac ugcaaccuga agcaccugag acugaagacc     2820

uacgagacca accuggagau caagaagcug cuggaggagg ugaaggagaa gaaccccaag     2880

cugaccaucg acugcaacgc cagcggcgcc accgcccccc ccugcugcga cuucuucugc     2940

uga                                                                   2943


<210>  9101
<211>  2943
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP7__Homo_sapiens__AAL69963

<400>  9101
augaccagcc cccagcugga guggacacuc caaacgcugc uugaacagcu gaacgaggac       60

gaacucaagu ccuucaaauc ucugcuuugg gccuuucccc uggaggaugu gcuccagaag      120

accccgugga gcgaagucga ggaggcugac ggcaaaaagc uggccgaaau ccugguuaau      180

acauccucug agaacuggau uagaaaugcg accgugaaca uccucgaaga gaugaaucug      240

acagagcuuu gcaaaauggc uaaggccgaa augauggagg auggacaggu gcaagaaauu      300

gacaaccccg agcuggggga ugccgaagag gacagcgagc ucgcuaagcc uggcgaaaaa      360

gagggguggc gcaauuccau ggaaaagcag ucucuggucu ggaaaaacac cuucuggcag      420

ggagauaucg acaauuuuca cgaugacgug acacuucgga accagagauu cauucccuuu      480

cugaauccuc ggacgccccg caagcucacc ccuuacaccg uugugcugca cggcccggcc      540

ggggucggaa aaacaacccu ggcuaagaag uguaugcucg auuggacaga cugcaaccug      600

agccccaccc uuagauaugc cuucuaccug uccuguaaag agcucagccg gaugggcccu      660

ugcucuuuug cggaacugau cuccaaggau uggcccgagc uucaagacga caucccuagc      720

auucuggccc aggcucagcg cauccucuuc gugguugaug gccuggacga gcugaaagug      780

cccccggggg cccucauuca ggauaucugu ggagacuggg aaaagaaaaa gccugucccc      840

gugcugcuug gcucucugcu caaaagaaag augcugccuc gggcugcccu ucuggugacg      900

acacgcccca gagcgcuccg ggaucugcaa cugcucgccc agcagcccau uuauguccgc      960

guugaggggu uucuggaaga ggacagacgg gcuuacuucc uucgccacuu uggagaugaa     1020

gaccaagcca ugagagcuuu cgagcugaug cgguccaaug ccgcccucuu ucagcugggc     1080

agcgcuccug cggugugcug gaucgugugu accacacuga aacuucagau ggagaaaggg     1140

gaagauccgg ucccuaccug ccucaccaga acaggacugu uccugcgcuu ccucuguucu     1200

cgguuucccc agggcgccca acugagaggc gcccuucgca cgcugucccu ccuggcugcc     1260

caggggcugu gggcucagau gagcguguuc caucgggagg accuugaaag acucggaguu     1320

caggaguccg aucugcgccu guuucucgac ggcgacauuc ugcggcaaga uagagugucu     1380

aaggggugcu auagcuucau ccaccuuucc uuucagcagu uccugaccgc ccucuuuuac     1440

gcgcuggaga aagaagaggg agaagaccgc gauggccaug cuugggacau cggggauguc     1500

cagaagcugc uuagcggaga ggaacggcuc aaaaaccccg accugauuca agugggccac     1560

uuccuguuug gccucgccaa ugagaagaga gccaaggagc uggaagcuac auucgggugu     1620

cgcaugucuc cugauaucaa acaggagcuu cugcagugca aggcccaccu ccaugcuaac     1680

aaaccccugu ccguuaccga ccugaaggaa gugcuuggau gccucuauga gagccaggaa     1740

gaggagcugg ccaaagucgu ggucgcgccg uuuaaggaaa uuucuaucca ccugacaaac     1800

accagcgagg ugaugcauug uuccuucucu cucaagcacu gccaagaucu gcagaaacuu     1860

agccugcagg uugccaaggg cguguuucuc gaaaauuaca uggacuucga gcuggauauu     1920

gaguucgaac gguguacgua ccugacaauc ccuaacuggg cuagacaaga ccuucggucc     1980

cugcgccucu ggaccgauuu uugcagccug uucucuucca auagcaaccu caaauuucug     2040

gaggucaagc agucuuuccu uuccgacagc uccgugagaa uccuguguga ccacguuacc     2100

cggucuacau gccaucucca gaaaguggaa auuaagaaug ucacccccga uacagccuau     2160

agagacuuuu gucuggcuuu caucgggaag aaaacgcuga cccaccuuac acuggccgga     2220

cauauugagu gggaacgcac caugaugcuc augcugugcg aucuccugcg gaaccacaag     2280

uguaaucuuc aguaccugag acucggcggg cauugcgcga caccugagca augggccgag     2340

uuuuucuaug ugcugaaagc uaaccagagc cugaagcacc uucgccuguc cgccaaugug     2400

cuccuggacg aaggcgcuau gcuccuguac aaaaccauga cgagacccaa gcacuuucuu     2460

cagaugcugu cucuggagaa cugucggcuc accgaagcca gcugcaaaga ucuggccgcu     2520

guucuugucg uguccaagaa gcugacacau cucugccugg cgaaaaaucc uaucggagac     2580

accggcguga aguuccucug ugaggggcug agcuaucccg auugcaaacu ucagacacug     2640

guccugcaac aguguucuau uaccaagcuc ggaugccgcu accuguccga agcccuucag     2700

gaggcuugua gccugacgaa ccucgaccug ucuaucaauc agaucgccag aggccucugg     2760

auucugugcc aagcccuuga gaacccgaau uguaaccuga aacaucugcg gcucaagaca     2820

uaugaaacca accuggagau caagaaacuu cuggaagagg ugaaggaaaa gaauccuaag     2880

cucacaauug auugcaacgc uuccggggcc accgcgccuc ccuguugcga cuuuuucugu     2940

uga                                                                   2943


<210>  9102
<211>  1048
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP8__Homo_sapiens__Q86W28

<400>  9102

Met Ser Asp Val Asn Pro Pro Ser Asp Thr Pro Ile Pro Phe Ser Ser 
1               5                   10                  15      


Ser Ser Thr His Ser Ser His Ile Pro Pro Trp Thr Phe Ser Cys Tyr 
            20                  25                  30          


Pro Gly Ser Pro Cys Glu Asn Gly Val Met Leu Tyr Met Arg Asn Val 
        35                  40                  45              


Ser His Glu Glu Leu Gln Arg Phe Lys Gln Leu Leu Leu Thr Glu Leu 
    50                  55                  60                  


Ser Thr Gly Thr Met Pro Ile Thr Trp Asp Gln Val Glu Thr Ala Ser 
65                  70                  75                  80  


Trp Ala Glu Val Val His Leu Leu Ile Glu Arg Phe Pro Gly Arg Arg 
                85                  90                  95      


Ala Trp Asp Val Thr Ser Asn Ile Phe Ala Ile Met Asn Cys Asp Lys 
            100                 105                 110         


Met Cys Val Val Val Arg Arg Glu Ile Asn Ala Ile Leu Pro Thr Leu 
        115                 120                 125             


Glu Pro Glu Asp Leu Asn Val Gly Glu Thr Gln Val Asn Leu Glu Glu 
    130                 135                 140                 


Gly Glu Ser Gly Lys Ile Arg Arg Tyr Lys Ser Asn Val Met Glu Lys 
145                 150                 155                 160 


Phe Phe Pro Ile Trp Asp Ile Thr Thr Trp Pro Gly Asn Gln Arg Asp 
                165                 170                 175     


Phe Phe Tyr Gln Gly Val His Arg His Glu Glu Tyr Leu Pro Cys Leu 
            180                 185                 190         


Leu Leu Pro Lys Arg Pro Gln Gly Arg Gln Pro Lys Thr Val Ala Ile 
        195                 200                 205             


Gln Gly Ala Pro Gly Ile Gly Lys Thr Ile Leu Ala Lys Lys Val Met 
    210                 215                 220                 


Phe Glu Trp Ala Arg Asn Lys Phe Tyr Ala His Lys Arg Trp Cys Ala 
225                 230                 235                 240 


Phe Tyr Phe His Cys Gln Glu Val Asn Gln Thr Thr Asp Gln Ser Phe 
                245                 250                 255     


Ser Glu Leu Ile Glu Gln Lys Trp Pro Gly Ser Gln Asp Leu Val Ser 
            260                 265                 270         


Lys Ile Met Ser Lys Pro Asp Gln Leu Leu Leu Leu Leu Asp Gly Phe 
        275                 280                 285             


Glu Glu Leu Thr Ser Thr Leu Ile Asp Arg Leu Glu Asp Leu Ser Glu 
    290                 295                 300                 


Asp Trp Arg Gln Lys Leu Pro Gly Ser Val Leu Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Ser Lys Thr Met Leu Pro Glu Ala Thr Leu Leu Ile Met Ile Arg Phe 
                325                 330                 335     


Thr Ser Trp Gln Thr Cys Lys Pro Leu Leu Lys Cys Pro Ser Leu Val 
            340                 345                 350         


Thr Leu Pro Gly Phe Asn Thr Met Glu Lys Ile Lys Tyr Phe Gln Met 
        355                 360                 365             


Tyr Phe Gly His Thr Glu Glu Gly Asp Gln Val Leu Ser Phe Ala Met 
    370                 375                 380                 


Glu Asn Thr Ile Leu Phe Ser Met Cys Arg Val Pro Val Val Cys Trp 
385                 390                 395                 400 


Met Val Cys Ser Gly Leu Lys Gln Gln Met Glu Arg Gly Asn Asn Leu 
                405                 410                 415     


Thr Gln Ser Cys Pro Asn Ala Thr Ser Val Phe Val Arg Tyr Ile Ser 
            420                 425                 430         


Ser Leu Phe Pro Thr Arg Ala Glu Asn Phe Ser Arg Lys Ile His Gln 
        435                 440                 445             


Ala Gln Leu Glu Gly Leu Cys His Leu Ala Ala Asp Ser Met Trp His 
    450                 455                 460                 


Arg Lys Trp Val Leu Gly Lys Glu Asp Leu Glu Glu Ala Lys Leu Asp 
465                 470                 475                 480 


Gln Thr Gly Val Thr Ala Phe Leu Gly Met Ser Ile Leu Arg Arg Ile 
                485                 490                 495     


Ala Gly Glu Glu Asp His Tyr Val Phe Thr Leu Val Thr Phe Gln Glu 
            500                 505                 510         


Phe Phe Ala Ala Leu Phe Tyr Val Leu Cys Phe Pro Gln Arg Leu Lys 
        515                 520                 525             


Asn Phe His Val Leu Ser His Val Asn Ile Gln Arg Leu Ile Ala Ser 
    530                 535                 540                 


Pro Arg Gly Ser Lys Ser Tyr Leu Ser His Met Gly Leu Phe Leu Phe 
545                 550                 555                 560 


Gly Phe Leu Asn Glu Ala Cys Ala Ser Ala Val Glu Gln Ser Phe Gln 
                565                 570                 575     


Cys Lys Val Ser Phe Gly Asn Lys Arg Lys Leu Leu Lys Val Ile Pro 
            580                 585                 590         


Leu Leu His Lys Cys Asp Pro Pro Ser Pro Gly Ser Gly Val Pro Gln 
        595                 600                 605             


Leu Phe Tyr Cys Leu His Glu Ile Arg Glu Glu Ala Phe Val Ser Gln 
    610                 615                 620                 


Ala Leu Asn Asp Tyr His Lys Val Val Leu Arg Ile Gly Asn Asn Lys 
625                 630                 635                 640 


Glu Val Gln Val Ser Ala Phe Cys Leu Lys Arg Cys Gln Tyr Leu His 
                645                 650                 655     


Glu Val Glu Leu Thr Val Thr Leu Asn Phe Met Asn Val Trp Lys Leu 
            660                 665                 670         


Ser Ser Ser Ser His Pro Gly Ser Glu Ala Pro Glu Ser Asn Gly Leu 
        675                 680                 685             


His Arg Trp Trp Gln Asp Leu Cys Ser Val Phe Ala Thr Asn Asp Lys 
    690                 695                 700                 


Leu Glu Val Leu Thr Met Thr Asn Ser Val Leu Gly Pro Pro Phe Leu 
705                 710                 715                 720 


Lys Ala Leu Ala Ala Ala Leu Arg His Pro Gln Cys Lys Leu Gln Lys 
                725                 730                 735     


Leu Leu Leu Arg Arg Val Asn Ser Thr Met Leu Asn Gln Asp Leu Ile 
            740                 745                 750         


Gly Val Leu Thr Gly Asn Gln His Leu Arg Tyr Leu Glu Ile Gln His 
        755                 760                 765             


Val Glu Val Glu Ser Lys Ala Val Lys Leu Leu Cys Arg Val Leu Arg 
    770                 775                 780                 


Ser Pro Arg Cys Arg Leu Gln Cys Leu Arg Leu Glu Asp Cys Leu Ala 
785                 790                 795                 800 


Thr Pro Arg Ile Trp Thr Asp Leu Gly Asn Asn Leu Gln Gly Asn Gly 
                805                 810                 815     


His Leu Lys Thr Leu Ile Leu Arg Lys Asn Ser Leu Glu Asn Cys Gly 
            820                 825                 830         


Ala Tyr Tyr Leu Ser Val Ala Gln Leu Glu Arg Leu Ser Ile Glu Asn 
        835                 840                 845             


Cys Asn Leu Thr Gln Leu Thr Cys Glu Ser Leu Ala Ser Cys Leu Arg 
    850                 855                 860                 


Gln Ser Lys Met Leu Thr His Leu Ser Leu Ala Glu Asn Ala Leu Lys 
865                 870                 875                 880 


Asp Glu Gly Ala Lys His Ile Trp Asn Ala Leu Pro His Leu Arg Cys 
                885                 890                 895     


Pro Leu Gln Arg Leu Val Leu Arg Lys Cys Asp Leu Thr Phe Asn Cys 
            900                 905                 910         


Cys Gln Asp Met Ile Ser Ala Leu Cys Lys Asn Lys Thr Leu Lys Ser 
        915                 920                 925             


Leu Asp Leu Ser Phe Asn Ser Leu Lys Asp Asp Gly Val Ile Leu Leu 
    930                 935                 940                 


Cys Glu Ala Leu Lys Asn Pro Asp Cys Thr Leu Gln Ile Leu Glu Leu 
945                 950                 955                 960 


Glu Asn Cys Leu Phe Thr Ser Ile Cys Cys Gln Ala Met Ala Ser Met 
                965                 970                 975     


Leu Arg Lys Asn Gln His Leu Arg His Leu Asp Leu Ser Lys Asn Ala 
            980                 985                 990         


Ile Gly Val Tyr Gly Ile Leu Thr Leu Cys Glu Ala Phe Ser Ser Gln 
        995                 1000                1005            


Lys Lys Arg Glu Glu Val Ile Phe Cys Ile Pro Ala Trp Thr Arg Ile 
    1010                1015                1020                


Thr Ser Phe Ser Pro Thr Pro His Pro Pro Asp Phe Thr Gly Lys Ser 
1025                1030                1035                1040


Asp Cys Leu Ser Gln Ile Asn Pro 
                1045            


<210>  9103
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP8__Homo_sapiens__DAA01242

<400>  9103
augagugacg ugaauccacc cucugacacc cccauucccu uuucauccuc cuccacucac       60

aguucucaua uuccgcccug gacauucucu ugcuaccccg gcuccccaug ugaaaauggg      120

gucaugcugu acaugagaaa cgugagccau gaggagcuac aacgguucaa gcagcucuua      180

cugacugagc ucaguacugg caccaugccc aucaccuggg accaggucga gacagccagc      240

ugggcagagg ugguucaucu cuugauagag cguuucccug gacgacgcgc uugggaugug      300

acuucgaaca ucuuugccau uaugaacugu gauaaaaugu guguuguagu ccgcagagag      360

auaaaugcca uucugccuac cuuggaacca gaggacuuga augugggaga aacacaggug      420

aaucuggagg aaggagaauc ugguaaaaua cggcgguaua aaucgaaugu gauggaaaag      480

uuuuucccca uaugggacau uacgacuugg ccuggaaacc agagggacuu cuucuaccaa      540

gguguacaca ggcacgagga guacuuacca ugucugcuuc ugcccaaaag accccagggu      600

agacagccca agaccguggc cauacaggga gcuccuggga ucggaaaaac aauccuggcc      660

aaaaagguga uguuugagug ggccagaaac aaguucuacg cccacaagcg cuggugugcu      720

uucuacuucc auugccaaga ggugaaccag acgacagacc agagcuucuc cgagcugauu      780

gagcaaaagu ggccuggauc ucaggaccuc gugucaaaga uuauguccaa acccgaccaa      840

cuucugcugc ucuuggaugg cuuugaggag cucacaucua cccucauuga cagacuggag      900

gaccugagug aagacuggag gcagaaauug ccugggucug uccuacugag caguuugcug      960

agcaaaacga ugcuuccaga ggccacgcua cugaucauga uaagauuuac cucuuggcag     1020

acaugcaagc ccuugcugaa augucccucu cucguaaccc uuccgggguu uaauacgaug     1080

gaaaaaauca aguauuucca gauguauuuu ggacacacag aggagggaga ccaagucuug     1140

aguuucgcca uggaaaacac cauucucuuc uccaugugcc gggucccugu gguuugcugg     1200

auggucugcu cuggucugaa acagcaaaug gagagaggaa acaaucucac acagucaugu     1260

ccaaaugcca ccucuguguu cguccgguau auuucuagcu uguuucccac cagagcugag     1320

aacuuuucca gaaagaucca ccaagcacaa cuggaagguc ugugucacuu ggccgcagac     1380

agcauguggc acaggaaaug gguguuaggu aaagaagauc uugaggaagc caagcuggau     1440

cagacgggag ucaccgccuu ccuuggcaug aguauucuuc ggagaauugc aggugaggaa     1500

gaccacuaug ucuuuacccu cgugacuuuu caggaauuuu uugcggccuu guuuuauguu     1560

cucuguuucc cacaaagacu caaaaauuuu cauguguuga gccacgugaa uauccagcgc     1620

cugauagcga gucccagagg aagcaaaagc uaucucucuc acaugggacu uuucuuauuc     1680

gguuuucuga acgaggccug cgcuucggcc guggaacagu cauuccaaug caaggugucu     1740

uucgguaaua agaggaaacu gcugaaaguc auaccucugu ugcauaaaug ugacccaccu     1800

ucuccgggca gugggguccc gcaguuauuc uacugucugc augaaauccg ggaggaagcc     1860

uuuguaagcc aagcccuaaa ugauuaucau aaaguugucu ugagaauugg caacaacaaa     1920

gaaguucaag ugucugcuuu uugccugaag cggugucaau auuugcauga gguggaacug     1980

accgucaccc ugaacuucau gaacgugugg aagcucagcu ccagcuccca uccuggcucu     2040

gaagcgccag agagcaaugg gcugcaucgu ugguggcaag acuuaugcuc uguguuugca     2100

acgaaugaua agcuggaagu ccugacuaug accaacagug uuuuggggcc uccuuuuuug     2160

aaggcucucg cggccgcacu gaggcacccu cagugcaaac ugcaaaagcu acuccuaagg     2220

cgugugaaua gcaccauguu gaaccaggac uuaaucggug uuuugacggg gaaccagcau     2280

cugagauacu uggaaauaca acauguggaa guggagucca aagcugugaa gcuucuaugc     2340

agggugcuga gauccccccg gugccgucug cagugucuca gguuggaaga cugcuuggcc     2400

accccuagaa uuuggacuga ucuuggcaau aaucuucaag guaacgggca ucuaaagacu     2460

cucauacuaa gaaaaaacuc ccuggagaac uguggggcgu auuaccuguc uguggcccag     2520

cuggagaggc ugucgauaga gaacugcaac cuuacacagc uuacuuguga aagccuugcc     2580

uccugucuca ggcagaguaa gaugcugacc caccugagcu uggcagaaaa cgccuugaaa     2640

gaugaagggg ccaagcauau uuggaaugcc cugccacacc ugagaugucc ucugcagagg     2700

cugguacuga gaaaguguga cuugaccuuu aauugcuguc aggauaugau cucugcgcuc     2760

uguaaaaaua aaacccugaa aagucuugac cuaaguuuua auagccugaa ggaugauggg     2820

gugauccugc ugugugaggc ccugaagaac ccugacugua cauuacagau ccuggagcug     2880

gaaaacugcc uguucaccuc caucugcugc caggccaugg cuuccaugcu ccgcaaaaac     2940

caacaucuga gacaucugga cuugagcaag aaugcgauug gagucuaugg uauucugacc     3000

uugugcgagg ccuucucaag ccaaaagaag agagaagagg ucauuuucug uauuccugcc     3060

uggacucgaa uaacuagcuu cuccccaacu ccucacccac ccgacuucac gggaaaaagu     3120

gacugccuau cccagauuaa uccuuag                                         3147


<210>  9104
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP8__Homo_sapiens__DAA01242

<400>  9104
augagcgacg ugaacccgcc cuccgacacc cccauccccu ucagcuccag cuccacccac       60

agcucccaca ucccgcccug gacguucagc ugcuaccccg gcucccccug cgagaacggg      120

gucaugcugu acaugcgcaa cgugagccac gaggagcucc agcgguucaa gcagcugcug      180

cucaccgagc uguccaccgg caccaugccc aucacguggg accaggugga gaccgccagc      240

ugggccgagg ucgugcaccu ccucaucgag cgcuuccccg ggcggcgcgc gugggacgug      300

accuccaaca ucuucgccau caugaacugc gacaagaugu gcgucguggu gcggcgcgag      360

aucaacgcca uccugcccac ccuggagccc gaggaccuca acgucggcga gacccaggug      420

aaccuggagg agggggagag cggcaagauc cggcgcuaca aguccaacgu gauggagaag      480

uucuucccca ucugggacau caccaccugg ccgggcaacc agcgggacuu cuucuaccag      540

gggguccacc gccacgagga guaccugccc ugccuccugc ugcccaagcg gccccagggc      600

cgccagccga agaccguggc cauccagggg gcccccggca ucgggaagac gauccucgcg      660

aagaagguga uguucgagug ggcccggaac aaguucuacg cccacaagcg cuggugcgcc      720

uucuacuucc acugccagga ggucaaccag accaccgacc agagcuucuc cgagcugauc      780

gagcagaagu ggcccggcag ccaggaccug guguccaaga ucaugagcaa gcccgaccag      840

cuccugcugc uccuggacgg cuucgaggag cugaccagca cgcucaucga ccggcuggag      900

gaccuguccg aggacuggcg ccagaagcuc ccggggagcg ugcugcuguc cagccuccug      960

uccaagacca ugcugcccga ggcgacccuc cugaucauga uccgguucac cagcuggcag     1020

acgugcaagc cccugcucaa gugccccucc cuggucaccc ugccgggcuu caacaccaug     1080

gagaagauca aguacuucca gauguacuuc gggcacaccg aggagggcga ccaggugcuc     1140

agcuucgcca uggagaacac gauccuguuc uccaugugcc gcgugcccgu cgugugcugg     1200

auggugugca gcggccugaa gcagcagaug gagcggggga acaaccucac ccaguccugc     1260

cccaacgcca ccagcgucuu cgugcgcuac aucuccagcc uguuccccac ccgggccgag     1320

aacuucuccc gcaagaucca ccaggcccag cuggagggcc ucugccaccu ggcggccgac     1380

agcauguggc accgcaagug gguccugggg aaggaggacc ucgaggaggc caagcuggac     1440

cagacgggcg ugaccgccuu ccuggggaug uccauccugc ggcgcaucgc cggcgaggag     1500

gaccacuacg uguucacccu cgucaccuuc caggaguucu ucgcggcccu guucuacgug     1560

cugugcuucc cgcagcggcu caagaacuuc cacgugcuga gccacgucaa cauccagcgc     1620

cugaucgcca gcccccgggg cuccaagagc uaccucuccc acauggggcu guuccuguuc     1680

ggcuuccuca acgaggccug cgccagcgcg guggagcagu ccuuccagug caaggugagc     1740

uucgggaaca agcgcaagcu gcugaagguc aucccccucc ugcacaagug cgacccgccc     1800

ucccccggca gcggggugcc ccagcuguuc uacugccucc acgagauccg ggaggaggcc     1860

uucguguccc aggcccugaa cgacuaccac aaggucgugc ugcgcaucgg caacaacaag     1920

gaggugcagg ucagcgccuu cugccucaag cggugccagu accugcacga gguggagcug     1980

acggugaccc ucaacuucau gaacgucugg aagcugucca gcuccagcca cccgggcucc     2040

gaggcccccg agagcaacgg gcugcaccgc ugguggcagg accucugcuc cguguucgcg     2100

accaacgaca agcuggaggu gcugaccaug acgaacagcg uccucggccc gcccuuccug     2160

aaggcccugg ccgccgcgcu ccggcacccc cagugcaagc ugcagaagcu gcuccugcgc     2220

cgggugaacu ccaccaugcu gaaccaggac cucaucgggg ugcugaccgg caaccagcac     2280

cuccgcuacc uggagaucca gcacgucgag guggagagca aggccgugaa gcugcugugc     2340

cggguccucc gcagcccccg gugccgccug cagugccugc ggcucgagga cugccuggcc     2400

acgccccgca ucuggaccga ccuggggaac aaccuccagg gcaacggcca ccugaagacg     2460

cugauccucc gcaagaacuc ccuggagaac ugcggggccu acuaccugag cguggcccag     2520

cucgagcggc uguccaucga gaacugcaac cugacccagc ugaccugcga gagccuggcg     2580

uccugccugc gccagagcaa gaugcucacc caccuguccc uggccgagaa cgcccucaag     2640

gacgagggcg ccaagcacau cuggaacgcc cugccccacc uccggugccc gcugcagcgc     2700

cuggugcugc ggaagugcga ccucacguuc aacugcugcc aggacaugau cagcgcgcug     2760

ugcaagaaca agacccugaa gucccucgac cugagcuuca acucccugaa ggacgacggg     2820

gucauccucc ugugcgaggc ccugaagaac cccgacugca cccuccagau ccuggagcug     2880

gagaacugcc ucuucaccag caucugcugc caggccaugg ccuccaugcu gcgcaagaac     2940

cagcaccucc ggcaccugga ccugagcaag aacgccaucg gcguguacgg cauccugacg     3000

cucugcgagg cguucuccag ccagaagaag cgcgaggagg ugaucuucug cauccccgcc     3060

uggacccgga ucaccuccuu cagccccacc ccgcacccgc ccgacuucac ggggaagucc     3120

gacugccuga gccagaucaa ccccuga                                         3147


<210>  9105
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP8__Homo_sapiens__DAA01242

<400>  9105
auguccgacg ucaacccccc cuccgacacc cccauccccu ucuccuccuc cuccacccac       60

uccucccaca ucccccccug gaccuucucc ugcuaccccg gcucccccug cgagaacggc      120

gucaugcucu acaugcgcaa cgucucccac gaggagcucc agcgcuucaa gcagcuccuc      180

cucaccgagc ucuccaccgg caccaugccc aucaccuggg accaggucga gaccgccucc      240

ugggccgagg ucguccaccu ccucaucgag cgcuuccccg gccgccgcgc cugggacguc      300

accuccaaca ucuucgccau caugaacugc gacaagaugu gcgucgucgu ccgccgcgag      360

aucaacgcca uccuccccac ccucgagccc gaggaccuca acgucggcga gacccagguc      420

aaccucgagg agggcgaguc cggcaagauc cgccgcuaca aguccaacgu cauggagaag      480

uucuucccca ucugggacau caccaccugg cccggcaacc agcgcgacuu cuucuaccag      540

ggcguccacc gccacgagga guaccucccc ugccuccucc uccccaagcg cccccagggc      600

cgccagccca agaccgucgc cauccagggc gcccccggca ucggcaagac cauccucgcc      660

aagaagguca uguucgagug ggcccgcaac aaguucuacg cccacaagcg cuggugcgcc      720

uucuacuucc acugccagga ggucaaccag accaccgacc aguccuucuc cgagcucauc      780

gagcagaagu ggcccggcuc ccaggaccuc gucuccaaga ucauguccaa gcccgaccag      840

cuccuccucc uccucgacgg cuucgaggag cucaccucca cccucaucga ccgccucgag      900

gaccucuccg aggacuggcg ccagaagcuc cccggcuccg uccuccucuc cucccuccuc      960

uccaagacca ugcuccccga ggccacccuc cucaucauga uccgcuucac cuccuggcag     1020

accugcaagc cccuccucaa gugccccucc cucgucaccc uccccggcuu caacaccaug     1080

gagaagauca aguacuucca gauguacuuc ggccacaccg aggagggcga ccagguccuc     1140

uccuucgcca uggagaacac cauccucuuc uccaugugcc gcguccccgu cgucugcugg     1200

auggucugcu ccggccucaa gcagcagaug gagcgcggca acaaccucac ccaguccugc     1260

cccaacgcca ccuccgucuu cguccgcuac aucuccuccc ucuuccccac ccgcgccgag     1320

aacuucuccc gcaagaucca ccaggcccag cucgagggcc ucugccaccu cgccgccgac     1380

uccauguggc accgcaagug gguccucggc aaggaggacc ucgaggaggc caagcucgac     1440

cagaccggcg ucaccgccuu ccucggcaug uccauccucc gccgcaucgc cggcgaggag     1500

gaccacuacg ucuucacccu cgucaccuuc caggaguucu ucgccgcccu cuucuacguc     1560

cucugcuucc cccagcgccu caagaacuuc cacguccucu cccacgucaa cauccagcgc     1620

cucaucgccu ccccccgcgg cuccaagucc uaccucuccc acaugggccu cuuccucuuc     1680

ggcuuccuca acgaggccug cgccuccgcc gucgagcagu ccuuccagug caaggucucc     1740

uucggcaaca agcgcaagcu ccucaagguc aucccccucc uccacaagug cgaccccccc     1800

ucccccggcu ccggcguccc ccagcucuuc uacugccucc acgagauccg cgaggaggcc     1860

uucgucuccc aggcccucaa cgacuaccac aaggucgucc uccgcaucgg caacaacaag     1920

gagguccagg ucuccgccuu cugccucaag cgcugccagu accuccacga ggucgagcuc     1980

accgucaccc ucaacuucau gaacgucugg aagcucuccu ccuccuccca ccccggcucc     2040

gaggcccccg aguccaacgg ccuccaccgc ugguggcagg accucugcuc cgucuucgcc     2100

accaacgaca agcucgaggu ccucaccaug accaacuccg uccucggccc ccccuuccuc     2160

aaggcccucg ccgccgcccu ccgccacccc cagugcaagc uccagaagcu ccuccuccgc     2220

cgcgucaacu ccaccaugcu caaccaggac cucaucggcg uccucaccgg caaccagcac     2280

cuccgcuacc ucgagaucca gcacgucgag gucgagucca aggccgucaa gcuccucugc     2340

cgcguccucc gcuccccccg cugccgccuc cagugccucc gccucgagga cugccucgcc     2400

accccccgca ucuggaccga ccucggcaac aaccuccagg gcaacggcca ccucaagacc     2460

cucauccucc gcaagaacuc ccucgagaac ugcggcgccu acuaccucuc cgucgcccag     2520

cucgagcgcc ucuccaucga gaacugcaac cucacccagc ucaccugcga gucccucgcc     2580

uccugccucc gccaguccaa gaugcucacc caccucuccc ucgccgagaa cgcccucaag     2640

gacgagggcg ccaagcacau cuggaacgcc cucccccacc uccgcugccc ccuccagcgc     2700

cucguccucc gcaagugcga ccucaccuuc aacugcugcc aggacaugau cuccgcccuc     2760

ugcaagaaca agacccucaa gucccucgac cucuccuuca acucccucaa ggacgacggc     2820

gucauccucc ucugcgaggc ccucaagaac cccgacugca cccuccagau ccucgagcuc     2880

gagaacugcc ucuucaccuc caucugcugc caggccaugg ccuccaugcu ccgcaagaac     2940

cagcaccucc gccaccucga ccucuccaag aacgccaucg gcgucuacgg cauccucacc     3000

cucugcgagg ccuucuccuc ccagaagaag cgcgaggagg ucaucuucug cauccccgcc     3060

uggacccgca ucaccuccuu cucccccacc ccccaccccc ccgacuucac cggcaagucc     3120

gacugccucu cccagaucaa ccccuga                                         3147


<210>  9106
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP8__Homo_sapiens__DAA01242

<400>  9106
augagcgacg ugaauccccc uuccgauacc ccaaucccgu ucucuucaag uagcacacac       60

uccucucaua uucccccuug gacuuuuucg ugcuacccag gcucacccug ugagaacggg      120

gucaugcugu auaugagaaa cguuagccac gaggaacucc agagguucaa gcaacuucug      180

uugacggaau uaaguaccgg aacaaugccu auaacuuggg accaggugga gaccgccucc      240

ugggcugaag uagugcaucu gcuaaucgag cgguuuccag gucgccgagc augggauguc      300

acaucuaaua uuuucgccau caugaacugc gacaaaaugu gugugguugu gcguagagag      360

auuaaugcga uccuccccac ccuggaaccu gaggaucuua acgucggcga aacucaggug      420

aaucuggagg agggggaaag cggaaagaua aggcgguaca aauccaacgu aauggagaag      480

uuuuucccaa ucugggacau uacaaccugg ccgggcaauc agcgcgacuu uuucuaucaa      540

gguguucaca gacaugaaga guacuugccc ugccuccugc ugccuaaaag gccacagggg      600

cggcagccca agacgguggc uauccaggga gccccuggca uuggcaagac uauccucgca      660

aagaagguca uguuugaaug ggcccgcaac aaauucuaug cucacaagcg auggugugca      720

uuuuacuucc acugccaaga ggugaaucag accacagauc agucauuuag ugaguuaaua      780

gaacagaaau ggccagggag ccaagaucug gugucuaaga uuauguccaa gcccgaccag      840

cuuuugcugc uacucgaugg auucgaggaa cugacuucaa cccuuaucga cagacuggag      900

gauuugagcg aagacuggag gcagaaacuc ccggguagug uccuguuauc uucccugcuc      960

agcaagacaa ugcuuccuga ggccacccug uugauuauga uccgguucac gucguggcaa     1020

acuuguaaac cccuacugaa gugcccaucu cucguuacac ugccuggcuu uaacaccaug     1080

gagaaaauca aguauuucca gauguacuuu gggcauacug aagagggaga ccaggugcuu     1140

uccuucgcua uggaaaauac aauucuguuu ucaauguguc guguacccgu ggucugcugg     1200

auggugugua guggcuugaa acagcaaaug gagcgcggua acaaucucac ccagagcugc     1260

ccaaacgcca cguccguuuu cgugagauac auaucuagcc uguuucccac cagggcggaa     1320

aacuucucac ggaagaucca ccaggcacag uuagaggggc ugugccaucu agccgcugau     1380

aguauguggc accgaaagug gguccucgga aaagaggacc uggaagaggc caaacuugau     1440

caaacaggcg ugacugcauu uuugggcaug uccauucugc gcagaaucgc uggggaagag     1500

gaccacuaug uauucacccu cguuacauuu caggaguucu uugccgcgcu guucuacgug     1560

cuuuguuucc cucagaggcu gaaaaauuuu caugucuuga gccacgugaa cauacagcgg     1620

cucauugccu cuccacgcgg aucaaagagu uaucugagcc auauggguuu auuccuguuu     1680

ggcuuccuaa augaagcaug cgcuuccgcc gucgagcaau cuuuucagug uaaagugucg     1740

uucgggaaca agagaaagcu ccugaaaguu aucccgcuuu ugcacaagug cgaucccccu     1800

agcccaggau ccggcgugcc ccagcuguuu uacugucucc augaaaucag ggaggaggcu     1860

uucguaucac aggcccugaa ugacuaucac aaagucgugu uacguauugg uaacaauaag     1920

gaaguucaag ugagugcauu uugccugaaa cggugucagu accuucacga ggucgaauug     1980

acugugaccc ucaacuucau gaauguaugg aagcugucua gcuccucaca uccugggagc     2040

gaggccccag aaucuaacgg ccuacaccga ugguggcagg aucugugcuc cguguuugcu     2100

acaaaugaca agcucgaggu ucugaccaug acuaacagug uccuuggacc cccguucuug     2160

aaagcgcugg cagccgcuuu aagacauccu caauguaagc uccagaaacu gcuucugagg     2220

cgcgugaaua gcacgauguu gaaccaggau cucaucggcg ugcugacagg gaaucagcac     2280

cuacgguauc uggaaauuca acacgucgag guugagucua aggccgugaa acuccugugc     2340

agagugcuua gguccccacg cugucgauug cagugccugc gguuagaaga cugccucgca     2400

acuccccgua uauggaccga ucugggaaac aaccuucagg guaauggcca ucugaagacc     2460

cuaauccuca gaaagaacuc acuggagaau uguggggccu acuacuugag uguagcucag     2520

cuggaaaggu uaagcauuga gaacugcaau cucacacaac ugaccuguga aucgcuugcc     2580

uccugccugc gccagucuaa aauguugacu caccucagcc uggcagagaa cgcgcuaaag     2640

gacgagggag cuaaacauau cuggaaugcc cugccucacc uucggugucc ccuccagaga     2700

cuggucuuga ggaagugcga ccugacauuu aacuguugcc aggauaugau cucagcauua     2760

uguaaaaaua agacgcucaa aagucuggac cuuuccuuca acucucugaa ggaugacggc     2820

gugauuuugc ucugcgaagc ccugaagaau ccagauugua cccuacaaau acuggagcuu     2880

gaaaacugcc ucuucacuag caucugcugu caggcuaugg ccuccaugcu gcgcaaaaau     2940

cagcauuugc gacacuuaga ccugucaaag aacgcaauug guguuuaugg gauccucaca     3000

cugugcgagg cuuuuagcag ucagaaaaag cgggaggaag ugauuuucug uaucccugcc     3060

uggaccagaa uaacaucuuu uucccccacu ccacacccgc cugauuucac cggcaaaagc     3120

gacugccuuu cgcaaaucaa ucccuga                                         3147


<210>  9107
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP8__Homo_sapiens__DAA01242

<400>  9107
augagcgacg ugaacccccc cagcgacacc cccauccccu ucagcagcag cagcacccac       60

agcagccaca ucccccccug gaccuucagc ugcuaccccg gcagccccug cgagaacggc      120

gugaugcugu acaugagaaa cgugagccac gaggagcugc agagauucaa gcagcugcug      180

cugaccgagc ugagcaccgg caccaugccc aucaccuggg accaggugga gaccgccagc      240

ugggccgagg uggugcaccu gcugaucgag agauuccccg gcagaagagc cugggacgug      300

accagcaaca ucuucgccau caugaacugc gacaagaugu gcgugguggu gagaagagag      360

aucaacgcca uccugcccac ccuggagccc gaggaccuga acgugggcga gacccaggug      420

aaccuggagg agggcgagag cggcaagauc agaagauaca agagcaacgu gauggagaag      480

uucuucccca ucugggacau caccaccugg cccggcaacc agagagacuu cuucuaccag      540

ggcgugcaca gacacgagga guaccugccc ugccugcugc ugcccaagag accccagggc      600

agacagccca agaccguggc cauccagggc gcccccggca ucggcaagac cauccuggcc      660

aagaagguga uguucgagug ggccagaaac aaguucuacg cccacaagag auggugcgcc      720

uucuacuucc acugccagga ggugaaccag accaccgacc agagcuucag cgagcugauc      780

gagcagaagu ggcccggcag ccaggaccug gugagcaaga ucaugagcaa gcccgaccag      840

cugcugcugc ugcuggacgg cuucgaggag cugaccagca cccugaucga cagacuggag      900

gaccugagcg aggacuggag acagaagcug cccggcagcg ugcugcugag cagccugcug      960

agcaagacca ugcugcccga ggccacccug cugaucauga ucagauucac cagcuggcag     1020

accugcaagc cccugcugaa gugccccagc cuggugaccc ugcccggcuu caacaccaug     1080

gagaagauca aguacuucca gauguacuuc ggccacaccg aggagggcga ccaggugcug     1140

agcuucgcca uggagaacac cauccuguuc agcaugugca gagugcccgu ggugugcugg     1200

auggugugca gcggccugaa gcagcagaug gagagaggca acaaccugac ccagagcugc     1260

cccaacgcca ccagcguguu cgugagauac aucagcagcc uguuccccac cagagccgag     1320

aacuucagca gaaagaucca ccaggcccag cuggagggcc ugugccaccu ggccgccgac     1380

agcauguggc acagaaagug ggugcugggc aaggaggacc uggaggaggc caagcuggac     1440

cagaccggcg ugaccgccuu ccugggcaug agcauccuga gaagaaucgc cggcgaggag     1500

gaccacuacg uguucacccu ggugaccuuc caggaguucu ucgccgcccu guucuacgug     1560

cugugcuucc cccagagacu gaagaacuuc cacgugcuga gccacgugaa cauccagaga     1620

cugaucgcca gccccagagg cagcaagagc uaccugagcc acaugggccu guuccuguuc     1680

ggcuuccuga acgaggccug cgccagcgcc guggagcaga gcuuccagug caaggugagc     1740

uucggcaaca agagaaagcu gcugaaggug aucccccugc ugcacaagug cgaccccccc     1800

agccccggca gcggcgugcc ccagcuguuc uacugccugc acgagaucag agaggaggcc     1860

uucgugagcc aggcccugaa cgacuaccac aagguggugc ugagaaucgg caacaacaag     1920

gaggugcagg ugagcgccuu cugccugaag agaugccagu accugcacga gguggagcug     1980

accgugaccc ugaacuucau gaacgugugg aagcugagca gcagcagcca ccccggcagc     2040

gaggcccccg agagcaacgg ccugcacaga ugguggcagg accugugcag cguguucgcc     2100

accaacgaca agcuggaggu gcugaccaug accaacagcg ugcugggccc ccccuuccug     2160

aaggcccugg ccgccgcccu gagacacccc cagugcaagc ugcagaagcu gcugcugaga     2220

agagugaaca gcaccaugcu gaaccaggac cugaucggcg ugcugaccgg caaccagcac     2280

cugagauacc uggagaucca gcacguggag guggagagca aggccgugaa gcugcugugc     2340

agagugcuga gaagccccag augcagacug cagugccuga gacuggagga cugccuggcc     2400

acccccagaa ucuggaccga ccugggcaac aaccugcagg gcaacggcca ccugaagacc     2460

cugauccuga gaaagaacag ccuggagaac ugcggcgccu acuaccugag cguggcccag     2520

cuggagagac ugagcaucga gaacugcaac cugacccagc ugaccugcga gagccuggcc     2580

agcugccuga gacagagcaa gaugcugacc caccugagcc uggccgagaa cgcccugaag     2640

gacgagggcg ccaagcacau cuggaacgcc cugccccacc ugagaugccc ccugcagaga     2700

cuggugcuga gaaagugcga ccugaccuuc aacugcugcc aggacaugau cagcgcccug     2760

ugcaagaaca agacccugaa gagccuggac cugagcuuca acagccugaa ggacgacggc     2820

gugauccugc ugugcgaggc ccugaagaac cccgacugca cccugcagau ccuggagcug     2880

gagaacugcc uguucaccag caucugcugc caggccaugg ccagcaugcu gagaaagaac     2940

cagcaccuga gacaccugga ccugagcaag aacgccaucg gcguguacgg cauccugacc     3000

cugugcgagg ccuucagcag ccagaagaag agagaggagg ugaucuucug cauccccgcc     3060

uggaccagaa ucaccagcuu cagccccacc ccccaccccc ccgacuucac cggcaagagc     3120

gacugccuga gccagaucaa ccccuga                                         3147


<210>  9108
<211>  3147
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP8__Homo_sapiens__DAA01242

<400>  9108
augagcgacg ugaauccccc uuccgauacc ccgauccccu ucucuagcuc cucuacacac       60

agcucccaua uuccucccug gacguuuucu ugcuacccug gcagccccug ugagaacggg      120

gucaugcugu auaugagaaa cguuucccac gaggaacucc agcgguucaa gcaacugcuu      180

cugaccgaac ucagcacagg aaccaugccu aucacauggg accaggugga gaccgccucu      240

ugggcugaag ugguccaucu gcuuauugag cgcuuuccgg gcagacgggc cugggaugug      300

acauccaaua ucuucgcgau uaugaacugc gacaaaaugu guguuguggu ccgcagagag      360

aucaaugcua uccugcccac ccucgaaccu gaggaucuga acguggggga aacgcagguu      420

aaucuggagg agggagaaag cggcaagauu cggcgcuaca aaucuaacgu gauggagaag      480

uuuuucccca ucugggacau uaccacaugg ccugggaauc agagagacuu uuucuaucaa      540

ggaguccacc ggcaugaaga guaccucccc ugccugcuuc ugccgaaacg cccucagggc      600

agacagccca agaccguggc cauccagggc gccccuggga uuggaaagac aauccucgcu      660

aaaaagguga uguuugaaug ggcccggaac aaauucuaug cucacaagcg cuggugugcc      720

uuuuacuucc acugccaaga ggucaaucag accacggauc aguccuuuag cgagcugauu      780

gaacagaaau ggcccggcuc ucaagaucuu guuuccaaga ucaugagcaa gcccgaccag      840

cugcuccugc ugcucgaugg guucgaggaa cugacaucca cccuuaucga cagacuggag      900

gaucucucug aagacuggcg gcagaaacug ccuggaagcg ugcuucuguc cagccuccug      960

ucuaagacaa ugcugccgga ggcgacccuc cugauuauga uccgcuucac cuccuggcaa     1020

acauguaaac cccuucugaa gugcccuagc cucgugacgc ugcccggcuu uaacaccaug     1080

gagaaaauua aguauuucca gauguacuuu gggcauacag aagagggaga ccagguccuu     1140

ucuuucgcca uggaaaauac cauccuguuu agcaugugua gagugccugu ugugugcugg     1200

auggucuguu ccggccucaa acagcaaaug gagcggggca acaaucugac acagucuugc     1260

cccaacgcua ccagcguguu cguuagauac auuuccagcc uguuuccgac gcgcgccgaa     1320

aacuucucuc ggaagaucca ccaggcucag cucgaggggc ugugccaucu ugccgcggau     1380

uccauguggc acagaaagug ggugcuggga aaagaggacc ucgaagaggc caagcuggau     1440

caaacaggcg ucaccgcuuu ucuggggaug agcauccuuc gccggauugc cggagaagag     1500

gaccacuaug uguucacccu cgucacauuu caggaguucu uugcugcccu guucuacgug     1560

cuguguuucc cucagagacu caaaaauuuu cauguucugu cucacgugaa cauccagcgc     1620

cuuauugcca gcccccgggg cagcaagucc uaucugucuc auaugggacu cuuccuguuu     1680

ggguuccuga augaggcuug cgcgagcgcc gucgaacaau ccuuucagug uaaagugucu     1740

uucggcaaca agagaaaacu ucucaaaguu aucccucugc ugcacaagug cgaucccccu     1800

agccccggcu ccggggugcc gcagcucuuu uacugucugc augaaauucg cgaggaggcu     1860

uucgucagcc aggcccuuaa ugacuaucac aaaguggugc ugcggaucgg aaacaauaag     1920

gaaguucaag ucucugccuu uugccucaaa agaugucagu accugcacga gguggaacug     1980

accgugacac uuaacuucau gaaugucugg aagcucuccu ccucuuccca uccuggcagc     2040

gaggcucccg aaucuaacgg gcugcaccgc ugguggcagg aucugugcag cguguuugcc     2100

acgaaugaca agcucgaggu ucugaccaug acaaacuccg ugcuuggacc cccuuuccug     2160

aaagcgcucg cugccgcccu gcggcauccg caauguaagc ugcagaaacu ucuccugaga     2220

cgggucaaua gcaccaugcu gaaccaggau cucaucggcg ugcugacagg gaaucagcac     2280

cuucgcuauc uggaaauuca acacguugag guggagucua aggcugucaa acuccugugc     2340

agagugcugc ggucccccag augucgccuu cagugccugc ggcucgaaga cugccuggcc     2400

accccuagaa ucuggacgga ucucggcaac aaccugcagg gaaauggcca ucuuaagacc     2460

cugauucucc gcaagaacag ccuggagaau uguggggcuu acuaccuguc cguugcccag     2520

cuugaaagac ugucuaucga gaacugcaau cucacacaac ugaccuguga aagccucgcg     2580

uccugccugc ggcagucuaa aaugcuuaca caccugagcc ucgccgagaa cgcucugaag     2640

gacgagggag ccaaacauau uuggaaugcu cugccccacc uucgcugucc ucugcagaga     2700

cucgugcugc ggaagugcga ccucaccuuu aacuguugcc aggauaugau cuccgcccug     2760

uguaaaaaua agacgcuuaa aucucuggac cugagcuuca acucccucaa ggaugacggc     2820

gucauucugc uuugcgaagc gcugaagaau cccgauugua cacuccaaau ccuggagcuc     2880

gaaaacugcc uguucaccag caucugcugu caggccaugg cuucuaugcu ucgcaaaaau     2940

cagcaucuga gacaccugga ccucuccaag aacgccauug ggguguaugg aauccugaca     3000

cuuugcgagg cuuuuagcuc ucaaaagaag cgggaggaag ugauuuucug uaucccugcc     3060

uggacccgca uuaccuccuu uagccccaca ccgcacccuc ccgauuucac gggcaaaucu     3120

gacugccugu cccagaucaa uccuuga                                         3147


<210>  9109
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NALP9__Homo_sapiens__Q7RTR0

<400>  9109

Met Ala Glu Ser Phe Phe Ser Asp Phe Gly Leu Leu Trp Tyr Leu Lys 
1               5                   10                  15      


Glu Leu Arg Lys Glu Glu Phe Trp Lys Phe Lys Glu Leu Leu Lys Gln 
            20                  25                  30          


Pro Leu Glu Lys Phe Glu Leu Lys Pro Ile Pro Trp Ala Glu Leu Lys 
        35                  40                  45              


Lys Ala Ser Lys Glu Asp Val Ala Lys Leu Leu Asp Lys His Tyr Pro 
    50                  55                  60                  


Gly Lys Gln Ala Trp Glu Val Thr Leu Asn Leu Phe Leu Gln Ile Asn 
65                  70                  75                  80  


Arg Lys Asp Leu Trp Thr Lys Ala Gln Glu Glu Met Arg Asn Lys Leu 
                85                  90                  95      


Asn Pro Tyr Arg Lys His Met Lys Glu Thr Phe Gln Leu Ile Trp Glu 
            100                 105                 110         


Lys Glu Thr Cys Leu His Val Pro Glu His Phe Tyr Lys Glu Thr Met 
        115                 120                 125             


Lys Asn Glu Tyr Lys Glu Leu Asn Asp Ala Tyr Thr Ala Ala Ala Arg 
    130                 135                 140                 


Arg His Thr Val Val Leu Glu Gly Pro Asp Gly Ile Gly Lys Thr Thr 
145                 150                 155                 160 


Leu Leu Arg Lys Val Met Leu Asp Trp Ala Glu Gly Asn Leu Trp Lys 
                165                 170                 175     


Asp Arg Phe Thr Phe Val Phe Phe Leu Asn Val Cys Glu Met Asn Gly 
            180                 185                 190         


Ile Ala Glu Thr Ser Leu Leu Glu Leu Leu Ser Arg Asp Trp Pro Glu 
        195                 200                 205             


Ser Ser Glu Lys Ile Glu Asp Ile Phe Ser Gln Pro Glu Arg Ile Leu 
    210                 215                 220                 


Phe Ile Met Asp Gly Phe Glu Gln Leu Lys Phe Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Ala Asp Leu Ser Asp Asp Trp Arg Gln Arg Gln Pro Met Pro Ile Ile 
                245                 250                 255     


Leu Ser Ser Leu Leu Gln Lys Lys Met Leu Pro Glu Ser Ser Leu Leu 
            260                 265                 270         


Ile Ala Leu Gly Lys Leu Ala Met Gln Lys His Tyr Phe Met Leu Arg 
        275                 280                 285             


His Pro Lys Leu Ile Lys Leu Leu Gly Phe Ser Glu Ser Glu Lys Lys 
    290                 295                 300                 


Ser Tyr Phe Ser Tyr Phe Phe Gly Glu Lys Ser Lys Ala Leu Lys Val 
305                 310                 315                 320 


Phe Asn Phe Val Arg Asp Asn Gly Pro Leu Phe Ile Leu Cys His Asn 
                325                 330                 335     


Pro Phe Thr Cys Trp Leu Val Cys Thr Cys Val Lys Gln Arg Leu Glu 
            340                 345                 350         


Arg Gly Glu Asp Leu Glu Ile Asn Ser Gln Asn Thr Thr Tyr Leu Tyr 
        355                 360                 365             


Ala Ser Phe Leu Thr Thr Val Phe Lys Ala Gly Ser Gln Ser Phe Pro 
    370                 375                 380                 


Pro Lys Val Asn Arg Ala Arg Leu Lys Ser Leu Cys Ala Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Ile Trp Thr Tyr Thr Phe Val Phe Ser His Gly Asp Leu Arg 
                405                 410                 415     


Arg Asn Gly Leu Ser Glu Ser Glu Gly Val Met Trp Val Gly Met Arg 
            420                 425                 430         


Leu Leu Gln Arg Arg Gly Asp Cys Phe Ala Phe Met His Leu Cys Ile 
        435                 440                 445             


Gln Glu Phe Cys Ala Ala Met Phe Tyr Leu Leu Lys Arg Pro Lys Asp 
    450                 455                 460                 


Asp Pro Asn Pro Ala Ile Gly Ser Ile Thr Gln Leu Val Arg Ala Ser 
465                 470                 475                 480 


Val Val Gln Pro Gln Thr Leu Leu Thr Gln Val Gly Ile Phe Met Phe 
                485                 490                 495     


Gly Ile Ser Thr Glu Glu Ile Val Ser Met Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Phe Pro Leu Ser Lys Asp Leu Lys Gln Glu Ile Thr Gln Cys Leu Glu 
        515                 520                 525             


Ser Leu Ser Gln Cys Glu Ala Asp Arg Glu Ala Ile Ala Phe Gln Glu 
    530                 535                 540                 


Leu Phe Ile Gly Leu Phe Glu Thr Gln Glu Lys Glu Phe Val Thr Lys 
545                 550                 555                 560 


Val Met Asn Phe Phe Glu Glu Val Phe Ile Tyr Ile Gly Asn Ile Glu 
                565                 570                 575     


His Leu Val Ile Ala Ser Phe Cys Leu Lys His Cys Gln His Leu Thr 
            580                 585                 590         


Thr Leu Arg Met Cys Val Glu Asn Ile Phe Pro Asp Asp Ser Gly Cys 
        595                 600                 605             


Ile Ser Asp Tyr Asn Glu Lys Leu Val Tyr Trp Arg Glu Leu Cys Ser 
    610                 615                 620                 


Met Phe Ile Thr Asn Lys Asn Phe Gln Ile Leu Asp Met Glu Asn Thr 
625                 630                 635                 640 


Ser Leu Asp Asp Pro Ser Leu Ala Ile Leu Cys Lys Ala Leu Ala Gln 
                645                 650                 655     


Pro Val Cys Lys Leu Arg Lys Leu Ile Phe Thr Ser Val Tyr Phe Gly 
            660                 665                 670         


His Asp Ser Glu Leu Phe Lys Ala Val Leu His Asn Pro His Leu Lys 
        675                 680                 685             


Leu Leu Ser Leu Tyr Gly Thr Ser Leu Ser Gln Ser Asp Ile Arg His 
    690                 695                 700                 


Leu Cys Glu Thr Leu Lys His Pro Met Cys Lys Ile Glu Glu Leu Ile 
705                 710                 715                 720 


Leu Gly Lys Cys Asp Ile Ser Ser Glu Val Cys Glu Asp Ile Ala Ser 
                725                 730                 735     


Val Leu Ala Cys Asn Ser Lys Leu Lys His Leu Ser Leu Val Glu Asn 
            740                 745                 750         


Pro Leu Arg Asp Glu Gly Met Thr Leu Leu Cys Glu Ala Leu Lys His 
        755                 760                 765             


Ser His Cys Ala Leu Glu Arg Leu Met Leu Met Tyr Cys Cys Leu Thr 
    770                 775                 780                 


Ser Val Ser Cys Asp Ser Ile Ser Glu Val Leu Leu Cys Ser Lys Ser 
785                 790                 795                 800 


Leu Ser Leu Leu Asp Leu Gly Ser Asn Ala Leu Glu Asp Asn Gly Val 
                805                 810                 815     


Ala Ser Leu Cys Ala Ala Leu Lys His Pro Gly Cys Ser Ile Arg Glu 
            820                 825                 830         


Leu Trp Leu Met Gly Cys Phe Leu Thr Ser Asp Ser Cys Lys Asp Ile 
        835                 840                 845             


Ala Ala Val Leu Ile Cys Asn Gly Lys Leu Lys Thr Leu Lys Leu Gly 
    850                 855                 860                 


His Asn Glu Ile Gly Asp Thr Gly Val Arg Gln Leu Cys Ala Ala Leu 
865                 870                 875                 880 


Gln His Pro His Cys Lys Leu Glu Cys Leu Gly Leu Gln Thr Cys Pro 
                885                 890                 895     


Ile Thr Arg Ala Cys Cys Asp Asp Ile Ala Ala Ala Leu Ile Ala Cys 
            900                 905                 910         


Lys Thr Leu Arg Ser Leu Asn Leu Asp Trp Ile Ala Leu Asp Ala Asp 
        915                 920                 925             


Ala Val Val Val Leu Cys Glu Ala Leu Ser His Pro Asp Cys Ala Leu 
    930                 935                 940                 


Gln Met Leu Gly Leu His Lys Ser Gly Phe Asp Glu Glu Thr Gln Lys 
945                 950                 955                 960 


Ile Leu Met Ser Val Glu Glu Lys Ile Pro His Leu Thr Ile Ser His 
                965                 970                 975     


Gly Pro Trp Ile Asp Glu Glu Tyr Lys Ile Arg Gly Val Leu Leu 
            980                 985                 990     


<210>  9110
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NALP9__Homo_sapiens__AAI36584

<400>  9110
auggcagaau cuuuuuuuuc ggauuuuggc uuguuguggu aucugaagga gcucagaaag       60

gaagaguuuu ggaaauuuaa ggagcuccuc aaacaaccuu uggagaaauu ugaacucaag      120

ccaauccccu gggcugagcu gaagaaggcc uccaaagaag auguagcaaa gcugcuggac      180

aaacauuacc caggaaagca ggcaugggag guaacacuga accuguuucu acagaucaau      240

aggaaagauc ucuggacaaa ggcucaggaa gagaugagaa auaagcuaaa cccauacaga      300

aagcauauga aggaaacauu ucaacucaua ugggagaagg aaaccugucu ucacgucccu      360

gagcauuucu acaaagaaac caugaaaaau gaguauaaag aauugaauga cgcauauacu      420

gcugcggcua gacgacacac ugugguccug gaagguccug auggaauugg aaaaacaacc      480

cuuuuaagaa aagugauguu ggacugggca gagggaaacu uauggaagga cagguucaca      540

uuuguguuuu uccucaaugu cugugaaaug aacgguaucg cagagaccag cuuacuggag      600

cuccucucua gggacuggcc ggagucuuca gagaagaucg aagacauuuu uucccagcca      660

gagagaauuc uguucaucau ggauggcuuu gagcaacuga aguuuaacuu acaacuuaag      720

gcugacuuga gcgaugauug gaggcagcgg cagccaaugc caauuauccu gagcaguuug      780

uugcaaaaaa agaugcuucc agaauccucu cuccuuauug cauuaggaaa acuggcuaug      840

caaaaacacu auuuuauguu gcggcaucca aaacucauaa agcucuuagg auucagugaa      900

ucugaaaaga agucguauuu cuccuacuuc uuuggugaga agagcaaagc ccugaaaguc      960

uucaauuuug ugagagauaa ugggccgcug uuuaucuugu gccauaaucc cuuuacgugc     1020

ugguuggucu guacuugugu gaaacagagg cuagagaggg gagaagaccu ugaaauaaac     1080

ucccaaaaca ccaccuauuu auaugcaucc uuuuuaacaa cuguauucaa agcaggaagu     1140

cagaguuuuc caccuaaggu gaacagagcc cgacuaaaaa gccugugugc uuuggcugca     1200

gagggaauuu ggacauauac auuuguauuu ucccaugggg aucuccggag gaauggguua     1260

ucugagucug agggcgugau gugggugggu augagacucc uccaaaggag aggggacugu     1320

uuugccuuca ugcaucugug uauccaagag uuuugugccg ccauguuuua uuugcucaaa     1380

cgacccaaag acgauccuaa cccggccauu ggaagcauaa cccagcuugu aagagcaagu     1440

gugguucagc cucaaacccu cuugacccag guggggauau ucauguuugg aauuucaaca     1500

gaagaaaucg ucagcaugcu ggagaccucc uuugguuuuc cacugucaaa agaccuaaag     1560

caggaaauaa cccaaugccu ugaaaguuua agucaaugug aagcugauag ggaagccaua     1620

gcuuuccagg aacuauucau ugguuuguuu gaaacucagg aaaaagaauu uguaaccaaa     1680

gugaugaauu ucuuugaaga aguuuucauu uauauuggua acauagaaca uuugguaaua     1740

gcuucauucu gccugaagca uugucaacau uuaacgacac uucgcaugug uguggagaau     1800

aucuuuccag augacucagg augcaucuca gauuacaaug agaagcucgu cuacuggcgg     1860

gagcuuugcu caauguucau uaccaacaag aacuuccaga uuuuagacau ggaaaauacc     1920

agccucgaug aucccucccu ggcgauucuu ugcaaagcgc uggcucagcc uguuuguaaa     1980

cuccgaaaac ucauauuuac uucuguguac uuuggacaug auucagaauu auuuaaggca     2040

guucuucaca acccucaucu gaaacuucug agccuguacg gcacuagccu cucccagucu     2100

gacaucagac accuguguga gacgcugaaa cauccaaugu gcaagauaga agagcugaua     2160

cugggaaagu gugacaucuc cagugaaguu ugugaagaca ucgccuccgu ccuggccugc     2220

aacagcaagc ugaaacaccu cuccuuggua gaaaaucccu ugagggacga aggaaugacg     2280

uugcugugug aagcccugaa gcacucacac ugugcccugg agaggcugau guugauguac     2340

ugcugucuca ccucugucuc cugugacucc auuuccgaag uccucuugug caguaagucc     2400

cugucccucc ucgaucuggg cucaaaugcc cuggaagaua auggaguggc aucucugugu     2460

gcagcgcuga agcacccagg cugcagcaua cgggagcugu gguugauggg cuguuuccuu     2520

acuuccgauu ccuguaagga cauugcugcu guucuuauuu gcaaugggaa acugaagacc     2580

cugaaacuug ggcauaauga aauaggagac acugguguca gacaguuaug ugcagcuuug     2640

cagcauccuc acuguaaauu agagugucuc gggcugcaaa cguguccgau cacccgugcc     2700

ugcugcgacg acaucgccgc agcacucauc gccugcaaaa cacugaggag ccugaaccuc     2760

gacuggauug ccuuggaugc ugaugcagug guggugcugu gugaggcauu gagccacccg     2820

gacugugccc ugcagaugcu ggggcugcac aaaucuggcu uugaugaaga aacucagaag     2880

auccugaugu cuguggaaga aaaaauuccc caucugacca uuucacaugg accuuggauu     2940

gacgaggaau acaagaucag gggugugcuc cucuga                               2976


<210>  9111
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NALP9__Homo_sapiens__AAI36584

<400>  9111
auggccgaga gcuucuucuc cgacuucggc cugcucuggu accugaagga gcugcggaag       60

gaggaguucu ggaaguucaa ggagcuccug aagcagcccc uggagaaguu cgagcucaag      120

ccgauccccu gggccgagcu gaagaaggcg agcaaggagg acguggccaa gcugcucgac      180

aagcacuacc ccgggaagca ggccugggag gucacccuga accuguuccu ccagaucaac      240

cggaaggacc uguggaccaa ggcccaggag gagaugcgca acaagcugaa ccccuaccgg      300

aagcacauga aggagacguu ccagcucauc ugggagaagg agaccugccu gcacgugccg      360

gagcacuucu acaaggagac caugaagaac gaguacaagg agcugaacga cgccuacacc      420

gcggccgccc gccggcacac ggugguccuc gagggccccg acgggaucgg caagaccacc      480

cugcugcgca aggugaugcu cgacugggcc gaggggaacc uguggaagga ccgguucacc      540

uucguguucu uccugaacgu cugcgagaug aacggcaucg cggagacguc ccuccuggag      600

cugcucagcc gcgacuggcc cgaguccagc gagaagaucg aggacaucuu cucccagccc      660

gagcggaucc uguucaucau ggacggcuuc gagcagcuga aguucaaccu ccagcugaag      720

gccgaccuga gcgacgacug gcgccagcgg cagccgaugc ccaucauccu cuccagccug      780

cugcagaaga agaugcuccc cgaguccagc cugcugaucg cccucgggaa gcuggccaug      840

cagaagcacu acuucaugcu gcgccacccc aagcucauca agcugcuggg cuucuccgag      900

agcgagaaga aguccuacuu cagcuacuuc uucggggaga aguccaaggc ccucaaggug      960

uucaacuucg ugcgggacaa cggcccgcug uucauccugu gccacaaccc cuucacgugc     1020

uggcucgucu gcacgugcgu gaagcagcgc cuggagcgcg gggaggaccu ggagaucaac     1080

agccagaaca ccaccuaccu guacgcgucc uuccucacca ccguguucaa ggccggcagc     1140

cagagcuucc cgcccaaggu caaccgggcc cggcugaagu cccugugcgc ccucgccgcg     1200

gagggcaucu ggaccuacac cuucguguuc agccacgggg accugcgccg gaacggccug     1260

uccgagagcg agggggugau gugggucggc augcgccucc ugcagcggcg cggcgacugc     1320

uucgccuuca ugcaccugug cauccaggag uucugcgccg ccauguucua ccuccugaag     1380

cgccccaagg acgaccccaa ccccgccauc ggguccauca cccagcuggu gcgggcgagc     1440

gugguccagc cccagacccu ccugacccag gugggcaucu ucauguucgg gaucuccacg     1500

gaggagaucg ugagcaugcu ggagaccucc uucggcuucc cgcucagcaa ggaccugaag     1560

caggagauca cccagugccu ggagucccuc agccagugcg aggccgaccg cgaggccauc     1620

gccuuccagg agcuguucau cgggcuguuc gagacccagg agaaggaguu cgucacgaag     1680

gugaugaacu ucuucgagga gguguucauc uacaucggca acaucgagca ccucgucauc     1740

gccuccuucu gccugaagca cugccagcac cugaccaccc uccggaugug cguggagaac     1800

aucuuccccg acgacagcgg cugcaucucc gacuacaacg agaagcuggu cuacuggcgc     1860

gagcugugca gcauguucau caccaacaag aacuuccaga uccucgacau ggagaacacg     1920

ucccuggacg accccagccu ggcgauccuc ugcaaggccc uggcccagcc cgugugcaag     1980

cugcggaagc ucaucuucac cuccguguac uucgggcacg acagcgagcu guucaaggcc     2040

guccugcaca acccgcaccu caagcugcug agccucuacg gcaccucccu gagccagucc     2100

gacauccgcc accugugcga gacccucaag caccccaugu gcaagaucga ggagcugauc     2160

cuggggaagu gcgacaucag cuccgaggug ugcgaggaca ucgcgagcgu gcucgccugc     2220

aacuccaagc ugaagcaccu gagccucguc gagaaccccc ugcgggacga gggcaugacg     2280

cugcucugcg aggcccugaa gcacucccac ugcgcccugg agcgccucau gcugauguac     2340

ugcugccuga ccagcguguc cugcgacagc aucuccgagg ugcuccugug cagcaagucc     2400

cugagccucc uggaccuggg guccaacgcc cucgaggaca acggcgucgc gagccugugc     2460

gccgcccuga agcaccccgg cugcagcauc cgggagcucu ggcugauggg gugcuuccug     2520

accuccgaca gcugcaagga caucgccgcc gugcucaucu gcaacggcaa gcugaagacc     2580

cugaagcucg ggcacaacga gaucggcgac acgggggugc gccagcugug cgcggcccug     2640

cagcacccgc acugcaagcu cgagugccug ggccugcaga ccugccccau cacccgggcc     2700

ugcugcgacg acaucgccgc cgcgcucauc gccugcaaga cccugcgcuc ccugaaccuc     2760

gacuggaucg cccuggacgc cgacgcgguc guggugcugu gcgaggcccu cagccacccc     2820

gacugcgccc ugcagaugcu gggccuccac aaguccgggu ucgacgagga gacccagaag     2880

auccugauga gcgucgagga gaagaucccg caccugacga ucucccacgg ccccuggauc     2940

gacgaggagu acaagauccg cggggugcuc cuguga                               2976


<210>  9112
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NALP9__Homo_sapiens__AAI36584

<400>  9112
auggccgagu ccuucuucuc cgacuucggc cuccucuggu accucaagga gcuccgcaag       60

gaggaguucu ggaaguucaa ggagcuccuc aagcagcccc ucgagaaguu cgagcucaag      120

cccauccccu gggccgagcu caagaaggcc uccaaggagg acgucgccaa gcuccucgac      180

aagcacuacc ccggcaagca ggccugggag gucacccuca accucuuccu ccagaucaac      240

cgcaaggacc ucuggaccaa ggcccaggag gagaugcgca acaagcucaa ccccuaccgc      300

aagcacauga aggagaccuu ccagcucauc ugggagaagg agaccugccu ccacgucccc      360

gagcacuucu acaaggagac caugaagaac gaguacaagg agcucaacga cgccuacacc      420

gccgccgccc gccgccacac cgucguccuc gagggccccg acggcaucgg caagaccacc      480

cuccuccgca aggucaugcu cgacugggcc gagggcaacc ucuggaagga ccgcuucacc      540

uucgucuucu uccucaacgu cugcgagaug aacggcaucg ccgagaccuc ccuccucgag      600

cuccucuccc gcgacuggcc cgaguccucc gagaagaucg aggacaucuu cucccagccc      660

gagcgcaucc ucuucaucau ggacggcuuc gagcagcuca aguucaaccu ccagcucaag      720

gccgaccucu ccgacgacug gcgccagcgc cagcccaugc ccaucauccu cuccucccuc      780

cuccagaaga agaugcuccc cgaguccucc cuccucaucg cccucggcaa gcucgccaug      840

cagaagcacu acuucaugcu ccgccacccc aagcucauca agcuccucgg cuucuccgag      900

uccgagaaga aguccuacuu cuccuacuuc uucggcgaga aguccaaggc ccucaagguc      960

uucaacuucg uccgcgacaa cggcccccuc uucauccucu gccacaaccc cuucaccugc     1020

uggcucgucu gcaccugcgu caagcagcgc cucgagcgcg gcgaggaccu cgagaucaac     1080

ucccagaaca ccaccuaccu cuacgccucc uuccucacca ccgucuucaa ggccggcucc     1140

caguccuucc cccccaaggu caaccgcgcc cgccucaagu cccucugcgc ccucgccgcc     1200

gagggcaucu ggaccuacac cuucgucuuc ucccacggcg accuccgccg caacggccuc     1260

uccgaguccg agggcgucau gugggucggc augcgccucc uccagcgccg cggcgacugc     1320

uucgccuuca ugcaccucug cauccaggag uucugcgccg ccauguucua ccuccucaag     1380

cgccccaagg acgaccccaa ccccgccauc ggcuccauca cccagcucgu ccgcgccucc     1440

gucguccagc cccagacccu ccucacccag gucggcaucu ucauguucgg caucuccacc     1500

gaggagaucg ucuccaugcu cgagaccucc uucggcuucc cccucuccaa ggaccucaag     1560

caggagauca cccagugccu cgagucccuc ucccagugcg aggccgaccg cgaggccauc     1620

gccuuccagg agcucuucau cggccucuuc gagacccagg agaaggaguu cgucaccaag     1680

gucaugaacu ucuucgagga ggucuucauc uacaucggca acaucgagca ccucgucauc     1740

gccuccuucu gccucaagca cugccagcac cucaccaccc uccgcaugug cgucgagaac     1800

aucuuccccg acgacuccgg cugcaucucc gacuacaacg agaagcucgu cuacuggcgc     1860

gagcucugcu ccauguucau caccaacaag aacuuccaga uccucgacau ggagaacacc     1920

ucccucgacg accccucccu cgccauccuc ugcaaggccc ucgcccagcc cgucugcaag     1980

cuccgcaagc ucaucuucac cuccgucuac uucggccacg acuccgagcu cuucaaggcc     2040

guccuccaca acccccaccu caagcuccuc ucccucuacg gcaccucccu cucccagucc     2100

gacauccgcc accucugcga gacccucaag caccccaugu gcaagaucga ggagcucauc     2160

cucggcaagu gcgacaucuc cuccgagguc ugcgaggaca ucgccuccgu ccucgccugc     2220

aacuccaagc ucaagcaccu cucccucguc gagaaccccc uccgcgacga gggcaugacc     2280

cuccucugcg aggcccucaa gcacucccac ugcgcccucg agcgccucau gcucauguac     2340

ugcugccuca ccuccgucuc cugcgacucc aucuccgagg uccuccucug cuccaagucc     2400

cucucccucc ucgaccucgg cuccaacgcc cucgaggaca acggcgucgc cucccucugc     2460

gccgcccuca agcaccccgg cugcuccauc cgcgagcucu ggcucauggg cugcuuccuc     2520

accuccgacu ccugcaagga caucgccgcc guccucaucu gcaacggcaa gcucaagacc     2580

cucaagcucg gccacaacga gaucggcgac accggcgucc gccagcucug cgccgcccuc     2640

cagcaccccc acugcaagcu cgagugccuc ggccuccaga ccugccccau cacccgcgcc     2700

ugcugcgacg acaucgccgc cgcccucauc gccugcaaga cccuccgcuc ccucaaccuc     2760

gacuggaucg cccucgacgc cgacgccguc gucguccucu gcgaggcccu cucccacccc     2820

gacugcgccc uccagaugcu cggccuccac aaguccggcu ucgacgagga gacccagaag     2880

auccucaugu ccgucgagga gaagaucccc caccucacca ucucccacgg ccccuggauc     2940

gacgaggagu acaagauccg cggcguccuc cucuga                               2976


<210>  9113
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NALP9__Homo_sapiens__AAI36584

<400>  9113
auggccgaga gcuucuuuuc cgacuucggc cugcucuggu accuuaagga acugagaaaa       60

gaggaauuuu ggaaguucaa agaguuguua aagcagcccc uggaaaaauu ugagcuaaag      120

ccuaucccau gggcugagcu caagaaagca ucuaaggaag auguggccaa acugcuugac      180

aagcacuauc cggggaaaca agcgugggag gucacccuga acuuguuccu ccagauuaau      240

aggaaggauc uguggacaaa ggcucaggaa gagaugcgga acaaacugaa ucccuaccgc      300

aagcauauga aagagacuuu ucagcucaua ugggaaaagg agacgugcuu acacguuccu      360

gaacauuucu auaaagagac caugaagaac gaauacaaag agcugaauga cgccuauaca      420

gcagccgcuc gacgucacac ugugguacuu gagggaccag augguaucgg caagaccaca      480

uugcugagaa aggugaugcu agacugggca gaagggaacc ucuggaaaga uagguuuacc      540

uucgucuuuu uccugaaugu gugugagaug aacggaauug ccgaaacuuc acuucuggag      600

uugcucaguc gggacuggcc cgaaagcucc gagaagaucg aggauauuuu uagccaaccu      660

gaacgcaucc uguucauaau ggacggcuuc gagcaguuaa aauuuaaucu gcagcucaag      720

gcugaucuuu cggacgauug gagacagagg caaccaaugc ccaucauucu gucaucuuug      780

cuacagaaaa agaugcugcc ugaaaguucc cuccugaucg cccuugguaa gcuggcgaug      840

cagaaacauu acuucauguu gcggcaccca aagcucauua aacuguuagg guuuucugag      900

agcgaaaaga aauccuauuu cucauacuuu uucggagaga agaguaaggc acugaaaguu      960

uuuaacuucg ugcgcgacaa uggcccgcua uuuauccucu gccacaaccc cuucacaugu     1020

uggcuggucu gcaccugugu gaagcagcga cuugagagag gcgaagacuu ggagauaaau     1080

agccaaaaca cgacuuaccu guaugccucu uuucucacca caguauucaa agcugggucc     1140

cagucauuuc cuccaaaggu uaauagggcc cggcugaaaa gccuuugcgc acuggcugcc     1200

gaaggaauuu ggacuuacac cuucguguuc agucauggug auuugcgucg caacggccuc     1260

ucugaguccg agggggucau guggguggga augagacugu uacagaggcg gggcgacugu     1320

uuugcguuca ugcaccugug cauccaagaa uuuugugccg caauguucua ucuacucaag     1380

cgacccaagg augacccuaa cccagcuauu gguagcauca cacagcuggu gcgcgccucg     1440

gucguucagc cccagacccu uuugacgcaa guggggaucu uuauguucgg aauuucuacu     1500

gaggaaauag uauccaugcu ggagacauca uuuggcuucc cgcucaguaa agaucugaag     1560

caggaaauca cccagugcuu agagagccug ucccagugug aggcugacag agaagccauu     1620

gcauuucaag agcuuuucau cggcuuguuu gaaacucagg agaaagaauu ugugacaaag     1680

gucaugaauu ucuucgagga gguguucaua uacauuggga acaucgaaca ucucguuauc     1740

gccucuuuuu gccugaaaca cugccagcac cuaaccacgc ugaggaugug uguggagaau     1800

auuuucccug augacagcgg augcaucuca gauuauaacg aaaagcucgu cuacuggcgg     1860

gagcugugua guauguuuau uaccaauaaa aacuuccaga uacuugacau ggaaaauaca     1920

uccuuggaug accccagccu ggcuaucuua ugcaaggcgc ucgcacaacc aguguguaag     1980

cugcgcaaac uuauuuuuac uucuguauau uucggucaug acucagagcu guuuaaggcc     2040

guuuugcaca acccucaucu caaacugcua agucuguacg gcaccagccu cucccagucu     2100

gauaucagac accugugcga gacacuuaag caucccaugu guaaaaucga agaguugauu     2160

cuggggaagu gcgacauauc gagcgaagug ugugaggaua ucgcuuccgu cuuagccugc     2220

aauucaaagc ucaaacaccu gagucuugug gagaacccac ugagggacga aggaaugacu     2280

cuacucugug aggcacugaa gcacucucau ugcgccuugg aacgucugau guuaauguac     2340

ugcugucuca ccagcgucuc cugcgauuca auuagcgagg ugcugcuuug uucuaaaucc     2400

cugaguuugc ucgaccuggg cagcaaugcu cuagaagaua acgguguugc cucucugugc     2460

gcagcgcuua agcaccccgg guguuccauc cgggagcucu ggcugauggg cugcuucuug     2520

acaucagaca guuguaaaga uauugcugcc gugcugaucu gcaauggaaa guuaaagacc     2580

cucaaacugg gccauaacga gauaggggac acuggaguac gacagcuuug ugcagcccug     2640

cagcacccuc acugcaaguu ggaaugucuc ggucugcaaa cgugcccaau cacaagagcu     2700

ugcugugaug acauugccgc agcucuaauc gccugcaaaa cccugaggag ccuuaaucuc     2760

gauuggauug cgcuggacgc cgacgcuguc gugguuuugu gugaggcauu aucgcauccg     2820

gauugcgccc ugcagaugcu cggccugcac aaguccgggu uugacgaaga gacucagaaa     2880

auccuuaugu cuguggaaga gaagauaccc caucugacca uuagccacgg accuuggauc     2940

gaugaggaau auaagauucg cggcgucuug cuauga                               2976


<210>  9114
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NALP9__Homo_sapiens__AAI36584

<400>  9114
auggccgaga gcuucuucag cgacuucggc cugcuguggu accugaagga gcugagaaag       60

gaggaguucu ggaaguucaa ggagcugcug aagcagcccc uggagaaguu cgagcugaag      120

cccauccccu gggccgagcu gaagaaggcc agcaaggagg acguggccaa gcugcuggac      180

aagcacuacc ccggcaagca ggccugggag gugacccuga accuguuccu gcagaucaac      240

agaaaggacc uguggaccaa ggcccaggag gagaugagaa acaagcugaa ccccuacaga      300

aagcacauga aggagaccuu ccagcugauc ugggagaagg agaccugccu gcacgugccc      360

gagcacuucu acaaggagac caugaagaac gaguacaagg agcugaacga cgccuacacc      420

gccgccgcca gaagacacac cguggugcug gagggccccg acggcaucgg caagaccacc      480

cugcugagaa aggugaugcu ggacugggcc gagggcaacc uguggaagga cagauucacc      540

uucguguucu uccugaacgu gugcgagaug aacggcaucg ccgagaccag ccugcuggag      600

cugcugagca gagacuggcc cgagagcagc gagaagaucg aggacaucuu cagccagccc      660

gagagaaucc uguucaucau ggacggcuuc gagcagcuga aguucaaccu gcagcugaag      720

gccgaccuga gcgacgacug gagacagaga cagcccaugc ccaucauccu gagcagccug      780

cugcagaaga agaugcugcc cgagagcagc cugcugaucg cccugggcaa gcuggccaug      840

cagaagcacu acuucaugcu gagacacccc aagcugauca agcugcuggg cuucagcgag      900

agcgagaaga agagcuacuu cagcuacuuc uucggcgaga agagcaaggc ccugaaggug      960

uucaacuucg ugagagacaa cggcccccug uucauccugu gccacaaccc cuucaccugc     1020

uggcuggugu gcaccugcgu gaagcagaga cuggagagag gcgaggaccu ggagaucaac     1080

agccagaaca ccaccuaccu guacgccagc uuccugacca ccguguucaa ggccggcagc     1140

cagagcuucc cccccaaggu gaacagagcc agacugaaga gccugugcgc ccuggccgcc     1200

gagggcaucu ggaccuacac cuucguguuc agccacggcg accugagaag aaacggccug     1260

agcgagagcg agggcgugau gugggugggc augagacugc ugcagagaag aggcgacugc     1320

uucgccuuca ugcaccugug cauccaggag uucugcgccg ccauguucua ccugcugaag     1380

agacccaagg acgaccccaa ccccgccauc ggcagcauca cccagcuggu gagagccagc     1440

guggugcagc cccagacccu gcugacccag gugggcaucu ucauguucgg caucagcacc     1500

gaggagaucg ugagcaugcu ggagaccagc uucggcuucc cccugagcaa ggaccugaag     1560

caggagauca cccagugccu ggagagccug agccagugcg aggccgacag agaggccauc     1620

gccuuccagg agcuguucau cggccuguuc gagacccagg agaaggaguu cgugaccaag     1680

gugaugaacu ucuucgagga gguguucauc uacaucggca acaucgagca ccuggugauc     1740

gccagcuucu gccugaagca cugccagcac cugaccaccc ugagaaugug cguggagaac     1800

aucuuccccg acgacagcgg cugcaucagc gacuacaacg agaagcuggu guacuggaga     1860

gagcugugca gcauguucau caccaacaag aacuuccaga uccuggacau ggagaacacc     1920

agccuggacg accccagccu ggccauccug ugcaaggccc uggcccagcc cgugugcaag     1980

cugagaaagc ugaucuucac cagcguguac uucggccacg acagcgagcu guucaaggcc     2040

gugcugcaca acccccaccu gaagcugcug agccuguacg gcaccagccu gagccagagc     2100

gacaucagac accugugcga gacccugaag caccccaugu gcaagaucga ggagcugauc     2160

cugggcaagu gcgacaucag cagcgaggug ugcgaggaca ucgccagcgu gcuggccugc     2220

aacagcaagc ugaagcaccu gagccuggug gagaaccccc ugagagacga gggcaugacc     2280

cugcugugcg aggcccugaa gcacagccac ugcgcccugg agagacugau gcugauguac     2340

ugcugccuga ccagcgugag cugcgacagc aucagcgagg ugcugcugug cagcaagagc     2400

cugagccugc uggaccuggg cagcaacgcc cuggaggaca acggcguggc cagccugugc     2460

gccgcccuga agcaccccgg cugcagcauc agagagcugu ggcugauggg cugcuuccug     2520

accagcgaca gcugcaagga caucgccgcc gugcugaucu gcaacggcaa gcugaagacc     2580

cugaagcugg gccacaacga gaucggcgac accggcguga gacagcugug cgccgcccug     2640

cagcaccccc acugcaagcu ggagugccug ggccugcaga ccugccccau caccagagcc     2700

ugcugcgacg acaucgccgc cgcccugauc gccugcaaga cccugagaag ccugaaccug     2760

gacuggaucg cccuggacgc cgacgccgug guggugcugu gcgaggcccu gagccacccc     2820

gacugcgccc ugcagaugcu gggccugcac aagagcggcu ucgacgagga gacccagaag     2880

auccugauga gcguggagga gaagaucccc caccugacca ucagccacgg ccccuggauc     2940

gacgaggagu acaagaucag aggcgugcug cuguga                               2976


<210>  9115
<211>  2976
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NALP9__Homo_sapiens__AAI36584

<400>  9115
auggccgaga gcuucuuuuc cgacuucggc cugcucuggu accugaagga acuuagaaaa       60

gaggaauuuu ggaaguucaa agagcugcuc aagcagcccc uggaaaaauu ugagcuuaag      120

ccuaucccgu gggcugagcu gaagaaagcc ucuaaggaag auguggcgaa acuccuggac      180

aagcacuauc ccgggaaaca ggcuugggag gucacccuga accucuuccu gcaaauuaau      240

cggaaggauc uuuggacaaa ggcccaggaa gagaugcgca acaaacugaa uccuuacaga      300

aagcauauga aagagacguu ucagcucauc ugggaaaagg agaccugccu gcacguuccc      360

gaacauuucu auaaagagac aaugaagaac gaauacaaag agcuuaauga cgccuauacc      420

gcugccgcuc ggcgccacac aguggugcug gagggaccug auggcauugg gaagaccaca      480

cuccugagaa aggucaugcu ggacugggcc gaaggaaacc ucuggaaaga ucgguuuacc      540

uucguguuuu uccugaaugu uugugagaug aacggcaucg cggaaacgag ccuucuggag      600

cuccuguccc gcgacuggcc cgaaucuagc gagaagauug aggauaucuu uucccaaccu      660

gaaagaaucc uuuucauuau ggacggguuc gagcagcuga aauuuaaucu ccagcugaag      720

gccgaucugu cugacgauug gcggcagcgc caaccgaugc ccaucauucu cagcucccug      780

cuucagaaaa agaugcugcc ugaaagcucu cuccugaucg cucuuggaaa gcuggccaug      840

cagaaacauu acuucaugcu cagacacccc aagcugauua aacugcucgg cuuuuccgag      900

agcgaaaaga aaucuuauuu cuccuacuuu uucggcgaaa agagcaaggc ucugaaagug      960

uuuaacuucg uccgggacaa ugggccucuu uuuauccugu gccacaaccc cuucaccugu     1020

uggcucgugu gcacaugugu uaagcagcgc cuggagagag gagaagaccu ggagauuaau     1080

ucucaaaaca ccacauaccu uuaugccucc uuucucacca cgguguucaa agcgggcagc     1140

caguccuuuc cgccuaaggu caaucgggcc cgccugaaau cucugugcgc ucucgccgcu     1200

gaagggaucu ggacauacac cuucguguuc agccauggag aucugagacg gaacggccuu     1260

uccgagagcg agggggugau gugggucgga augagacugc uccagcgccg gggcgacugu     1320

uuugccuuca ugcaccugug cauccaagaa uuuugugccg cuauguucua ucugcuuaag     1380

agacccaagg augacccuaa ccccgcgauu ggcucuauca cacagcucgu ucgcgccucc     1440

guggugcagc cccagacccu gcugacccaa gucgggauuu uuauguucgg aaucagcaca     1500

gaggaaauug ugucuaugcu cgagacgagc uuuggcuucc cucuguccaa agaucuuaag     1560

caggaaauca cccagugccu ggagucucuc agccagugug aggcugaccg ggaagccauc     1620

gccuuucaag agcuguucau ugggcuguuu gaaacacagg agaaagaauu uguuaccaag     1680

gugaugaauu ucuucgagga ggucuucauc uacauuggaa acaucgaaca ucuugugauu     1740

gcuuccuuuu gccucaaaca cugccagcac cugacaaccc ugagaaugug uguugagaau     1800

aucuucccgg augacagcgg cugcaucucu gauuauaacg aaaagcucgu guacuggcgc     1860

gagcuguguu ccauguuuau uacgaauaaa aacuuccaga uccuugacau ggaaaauaca     1920

agccuggaug accccucucu cgccauucug ugcaaggcgc uggcucaacc ugucuguaaa     1980

cuucggaagc ucaucuuuac cuccguguau uucgggcaug acagcgagcu guuuaaggcc     2040

guccugcaca acccccaucu caaacugcuu ucccuguacg gaaccucucu cagccagucc     2100

gauauuagac accugugcga gacacugaag cauccuaugu guaaaaucga ggagcuuauu     2160

cugggcaagu gcgacaucuc uagcgaagug ugugaggaua ucgccuccgu ucucgcuugc     2220

aauagcaagc ugaaacaccu cucucuggug gagaaccccc uucgcgacga aggcaugacc     2280

cugcucugug aggcccugaa gcacucccau ugcgcucugg aacggcuuau gcugauguac     2340

ugcugucuca caagcgucuc uugcgauucc auuagcgagg ugcugcucug uucuaaaagc     2400

cugucccuuc uggaccucgg gagcaaugcc cuggaagaua acggaguugc gucucugugc     2460

gccgcucuua agcacccggg cuguuccauc agagagcugu ggcucauggg gugcuuccug     2520

acgagcgacu ccuguaaaga uauugccgcu gugcucaucu gcaauggaaa gcugaagacc     2580

cuuaaacugg gccauaacga gauuggggac acaggcgucc gccagcugug ugccgcgcuc     2640

cagcacccuc acugcaagcu ggaaugucuu ggacugcaaa ccugccccau cacacgggcc     2700

ugcugugaug acaucgcugc cgcucucauu gccugcaaaa cccugagauc ucucaaucug     2760

gauuggaucg cccuugacgc ugacgcggug gugguucugu gugaggcccu gagccauccu     2820

gauugcgcuc uccagaugcu gggccuucac aaguccgggu uugacgaaga gacgcagaaa     2880

auucugaugu cugucgaaga gaagaucccc caucucacca uuagccacgg accuuggauc     2940

gaugaggaau auaagauccg gggcgugcug cucuga                               2976


<210>  9116
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NF-kappaB__Homo_sapiens__A3F768

<400>  9116

Met Glu Lys Ile Leu Gln Met Ala Glu Gly Ile Asp Ile Gly Glu Met 
1               5                   10                  15      


Pro Ser Tyr Asp Leu Val Leu Ser Lys Pro Ser Lys Gly Gln Lys Arg 
            20                  25                  30          


His Leu Ser Thr Cys Asp Gly Gln Asn Pro Pro Lys Lys Gln Ala Gly 
        35                  40                  45              


Ser Lys Phe His Ala Arg Pro Arg Phe Glu Pro Val His Phe Val Ala 
    50                  55                  60                  


Ser Ser Ser Lys Asp Glu Gly Gln Glu Asp Pro Tyr Gly Pro Gln Thr 
65                  70                  75                  80  


Lys Glu Val Asn Glu Gln Thr His Phe Ala Ser Met Pro Arg Asp Ile 
                85                  90                  95      


Tyr Gln Asp Tyr Thr Gln Asp Ser Phe Ser Ile Gln Asp Gly Asn Ser 
            100                 105                 110         


Gln Tyr Cys Asp Ser Ser Gly Phe Ile Leu Thr Lys Asp Gln Pro Val 
        115                 120                 125             


Thr Ala Asn Met Tyr Phe Asp Ser Gly Asn Pro Ala Pro Ser Thr Thr 
    130                 135                 140                 


Ser Gln Gln Ala Asn Ser Gln Ser Thr Pro Glu Pro Ser Pro Ser Gln 
145                 150                 155                 160 


Thr Phe Pro Glu Ser Val Val Ala Glu Lys Gln Tyr Phe Ile Glu Lys 
                165                 170                 175     


Leu Thr Ala Thr Ile Trp Lys Asn Leu Ser Asn Pro Glu Met Thr Ser 
            180                 185                 190         


Gly Ser Asp Lys Ile Asn Tyr Thr Tyr Met Leu Thr Arg Cys Ile Gln 
        195                 200                 205             


Ala Cys Lys Thr Asn Pro Glu Tyr Ile Tyr Ala Pro Leu Lys Glu Ile 
    210                 215                 220                 


Pro Pro Ala Asp Ile Pro Lys Asn Lys Lys Leu Leu Thr Asp Gly Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Arg Cys Gln Asn Ile Tyr Leu Thr Thr Gly Tyr Ala 
                245                 250                 255     


Gly Ser Lys Asn Gly Ser Arg Asp Arg Ala Thr Glu Leu Ala Val Lys 
            260                 265                 270         


Leu Leu Gln Lys Arg Ile Glu Val Arg Val Val Arg Arg Lys Phe Lys 
        275                 280                 285             


His Thr Phe Gly Glu Asp Leu Val Val Cys Gln Ile Gly Met Ser Ser 
    290                 295                 300                 


Tyr Glu Phe Pro Pro Ala Leu Lys Pro Pro Glu Asp Leu Val Val Leu 
305                 310                 315                 320 


Gly Lys Asp Ala Ser Gly Gln Pro Ile Phe Asn Ala Ser Ala Lys His 
                325                 330                 335     


Trp Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile Gly Ile 
            340                 345                 350         


Leu Asn Asn Ser Ala Ser Phe Asn Lys Met Ser Ile Glu Tyr Lys Tyr 
        355                 360                 365             


Glu Met Met Pro Asn Arg Thr Trp Arg Cys Arg Val Phe Leu Gln Asp 
    370                 375                 380                 


His Cys Leu Ala Glu Gly Tyr Gly Thr Lys Lys Thr Ser Lys His Ala 
385                 390                 395                 400 


Ala Ala Asp Glu Ala Leu Lys Ile Leu Gln Lys Thr Gln Pro Thr Tyr 
                405                 410                 415     


Pro Ser Val Lys Ser Ser Gln Cys His Thr Gly Ser Ser Pro Arg Gly 
            420                 425                 430         


Ser Gly Lys Lys Lys Asp Ile Lys Asp Leu Val Val Tyr Glu Asn Ser 
        435                 440                 445             


Ser Asn Pro Val Cys Thr Leu Asn Asp Thr Ala Gln Phe Asn Arg Met 
    450                 455                 460                 


Thr Val Glu Tyr Val Tyr Glu Arg Met Thr Gly Leu Arg Trp Lys Cys 
465                 470                 475                 480 


Lys Val Ile Leu Glu Ser Glu Val Ile Ala Glu Ala Val Gly Val Lys 
                485                 490                 495     


Lys Thr Val Lys Tyr Glu Ala Ala Gly Glu Ala Val Lys Thr Leu Lys 
            500                 505                 510         


Lys Thr Gln Pro Thr Val Ile Asn Asn Leu Lys Lys Gly Ala Val Glu 
        515                 520                 525             


Asp Val Ile Ser Arg Asn Glu Ile Gln Gly Arg Ser Ala Glu Glu Ala 
    530                 535                 540                 


Tyr Lys Gln Gln Ile Lys Glu Asp Asn Ile Gly Asn Gln Leu Leu Arg 
545                 550                 555                 560 


Lys Met Gly Trp Thr Gly Gly Gly Leu Gly Lys Ser Gly Glu Gly Ile 
                565                 570                 575     


Arg Glu Pro Ile Ser Val Lys Glu Gln His Lys Arg Glu Gly Leu Gly 
            580                 585                 590         


Leu Asp Val Glu Arg Val Asn Lys Ile Ala Lys Arg Asp Ile Glu Gln 
        595                 600                 605             


Ile Ile Arg Asn Tyr Ala Arg Ser Glu Ser His Thr Asp Leu Thr Phe 
    610                 615                 620                 


Ser Arg Glu Leu Thr Asn Asp Glu Arg Lys Gln Ile His Gln Ile Ala 
625                 630                 635                 640 


Gln Lys Tyr Gly Leu Lys Ser Lys Ser His Gly Val Gly His Asp Arg 
                645                 650                 655     


Tyr Leu Val Val Gly Arg Lys Arg Arg Lys Glu Asp Leu Leu Asp Gln 
            660                 665                 670         


Leu Lys Gln Glu Gly Gln Val Gly His Tyr Glu Leu Val Met Pro Gln 
        675                 680                 685             


Ala Asn 
    690 


<210>  9117
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NF-kappaB__Homo_sapiens__ABN11234

<400>  9117
auggaaaaaa uucuccaaau ggcugaaggu auugauauug gggagaugcc uucauaugau       60

cuggugcugu ccaaaccuuc caaaggucaa aaacgccacc ucucaacaug ugauggucaa      120

aauccuccua aaaagcaagc cgguuccaaa uuccaugcga gaccucguuu ugagccugua      180

cauuuuguag cuaguaguuc aaaagaugaa ggacaggaag auccuuaugg cccucaaaca      240

aaagagguaa augaacaaac acauuuugcc agcaugccaa gagacaucua ccaagauuau      300

acucaagacu cuuucaguau acaagauggg aauucucagu auugugauuc aucaggauuc      360

auucucacaa aagaccagcc uguaacagcc aacauguauu uugacagugg gaacccugcc      420

ccaagcacca caucacagca ggcaaacucu cagucaacuc cugagccuuc accaucacag      480

acauuucccg agucuguggu agccgagaag caguauuuua uugaaaaauu aacggcgaca      540

aucuggaaga accuuucuaa uccagaaaug acuucuggau cugauaaaau uaauuauaca      600

uauauguuaa cucguuguau ucaggcgugu aagacaaauc cugaguauau auaugcuccu      660

uuaaaggaaa uuccuccugc cgacaucccc aaaaauaaaa aacuucuaac ugauggcuau      720

gcuugugaag uuagaugcca aaauaucuac uuaacuacag guuaugcugg cagcaagaau      780

ggguccaggg aucgagcuac agagcuagcu guaaaacucu ugcagaaacg uauugaaguu      840

agaguugucc ggcggaaauu caagcauaca uuuggagagg accucguggu gugucagauu      900

ggcauguccu ccuaugaauu uccuccagcu cugaagccac cagaagaccu gguggugcug      960

gguaaagaug cuuccgggca gccaauuuuu aaugcuucug ccaaacacug gaccaauuuu     1020

gucauuacag aaaaugcaaa ugaugcaauu gguauccuua acaauucugc cucauucaac     1080

aagaugucaa uugaauacaa auaugagaug augccaaauc gcacauggcg uugucgagug     1140

uuuuuacaag aucacugcuu agcugaaggu uauggaacca agaaaacaag uaaacaugca     1200

gcugccgacg aggcuuugaa aauucuucaa aaaacacagc ccacuuaucc aucugucaaa     1260

aguucacaau gccauacagg cucuucaccc agaggaucug gaaagaagaa agauauaaag     1320

gaucuuguag uuuaugagaa uucuucaaau cccgugugca cgcugaacga cacagcucag     1380

uuuaaccgaa ugacaguuga guaugucuau gaaaggauga caggccuccg cuggaaaugc     1440

aaagugauuc uagagaguga aguaauugca gaagcaguug gggugaagaa aacugucaaa     1500

uaugaagcug cuggggaagc ugugaaaacc cucaaaaaga cccagccaac ugucauuaac     1560

aacuugaaga aaggagcugu ugaagaugug auuucaagaa augaaauuca gggccgcuca     1620

gcagaggagg cuuacaaaca gcaaaucaaa gaagauaaua uuggaaauca gcugcugaga     1680

aagauggguu ggacuggugg ugguuuaggu aaaucuggug agggcauacg ggagccuauc     1740

ucagugaaag agcagcauaa gcgggaaggg cuuggucugg auguagagag ggugaauaaa     1800

auugccaaga gagauauuga acagaucauc agaaacuacg cccgcuccga gagccacaca     1860

gauuugacuu ucucuagaga gcugacuaau gaugaacgga agcaaauaca ucagauugcc     1920

cagaaguaug gucuuaagag uaagucucau ggggugggcc augauaggua ccuaguggua     1980

gguagaaaaa gacggaagga agaccuacua gaucagcuca aacaggaagg ccaagugggc     2040

cauuacgagc uuguuaugcc ucaagcaaau uga                                  2073


<210>  9118
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NF-kappaB__Homo_sapiens__ABN11234

<400>  9118
auggagaaga uccugcagau ggccgagggc aucgacaucg gggagaugcc cagcuacgac       60

cucgugcugu ccaagccgag caagggccag aagcgccacc uguccacgug cgacgggcag      120

aacccgccca agaagcaggc cggcagcaag uuccacgcgc ggccccgcuu cgagcccguc      180

cacuucgugg ccuccagcuc caaggacgag gggcaggagg accccuacgg cccccagacc      240

aaggagguga acgagcagac ccacuucgcc agcaugcccc gggacaucua ccaggacuac      300

acccaggacu ccuucagcau ccaggacggc aacucccagu acugcgacag cuccggguuc      360

auccucacca aggaccagcc ggucaccgcc aacauguacu ucgacagcgg caaccccgcc      420

cccuccacga ccagccagca ggcgaacucc cagagcaccc ccgagccguc ccccagccag      480

accuuccccg agagcguggu ggccgagaag caguacuuca ucgagaagcu gacggccacc      540

aucuggaaga accuguccaa ccccgagaug accagcgggu ccgacaagau caacuacacc      600

uacaugcuca cgcgcugcau ccaggccugc aagaccaacc cggaguacau cuacgcgccc      660

cugaaggaga ucccgcccgc cgacaucccc aagaacaaga agcugcucac cgacggcuac      720

gccugcgagg uccggugcca gaacaucuac cugaccacgg gguacgccgg cagcaagaac      780

ggcucccgcg accgggccac cgagcuggcg gugaagcucc ugcagaagcg caucgaggug      840

cgggucgugc gccggaaguu caagcacacc uucggggagg accugguggu cugccagauc      900

ggcaugagcu ccuacgaguu cccgcccgcc cucaagccgc ccgaggaccu gguggugcug      960

gggaaggacg ccagcggcca gcccaucuuc aacgccuccg ccaagcacug gaccaacuuc     1020

gucaucacgg agaacgcgaa cgacgccauc ggcauccuca acaacagcgc cuccuucaac     1080

aagaugagca ucgaguacaa guacgagaug augcccaacc gcaccuggcg gugccgcgug     1140

uuccugcagg accacugccu ggccgagggg uacggcacca agaagaccuc caagcacgcc     1200

gcggccgacg aggcccucaa gauccugcag aagacgcagc ccaccuaccc cagcgugaag     1260

uccagccagu gccacaccgg guccagcccc cggggcuccg ggaagaagaa ggacaucaag     1320

gaccuggucg uguacgagaa cagcagcaac cccgugugca cccucaacga cacggcccag     1380

uucaaccgca ugaccgucga guacguguac gagcggauga ccggccugcg cuggaagugc     1440

aaggugaucc uggaguccga ggucaucgcc gaggcggugg gcgucaagaa gaccgugaag     1500

uacgaggccg ccggggaggc cgugaagacg cucaagaaga cccagccgac cgucaucaac     1560

aaccugaaga agggcgcggu ggaggacgug aucagccgga acgagaucca ggggcgcucc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucggcaacca gcugcuccgg     1680

aagauggggu ggaccggcgg cgggcugggc aagagcgggg agggcauccg cgagcccauc     1740

uccgucaagg agcagcacaa gcgcgagggg cugggccucg acguggagcg ggugaacaag     1800

aucgccaagc gcgacaucga gcagaucauc cggaacuacg cccgcagcga gucccacacg     1860

gaccugaccu ucagccggga gcugaccaac gacgagcgca agcagaucca ccagaucgcg     1920

cagaaguacg gccucaaguc caagagccac ggggucggcc acgaccggua ccugguggug     1980

gggcgcaagc ggcgcaagga ggaccugcuc gaccagcuga agcaggaggg ccaggucggc     2040

cacuacgagc uggugaugcc ccaggccaac uga                                  2073


<210>  9119
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NF-kappaB__Homo_sapiens__ABN11234

<400>  9119
auggagaaga uccuccagau ggccgagggc aucgacaucg gcgagaugcc cuccuacgac       60

cucguccucu ccaagcccuc caagggccag aagcgccacc ucuccaccug cgacggccag      120

aaccccccca agaagcaggc cggcuccaag uuccacgccc gcccccgcuu cgagcccguc      180

cacuucgucg ccuccuccuc caaggacgag ggccaggagg accccuacgg cccccagacc      240

aaggagguca acgagcagac ccacuucgcc uccaugcccc gcgacaucua ccaggacuac      300

acccaggacu ccuucuccau ccaggacggc aacucccagu acugcgacuc cuccggcuuc      360

auccucacca aggaccagcc cgucaccgcc aacauguacu ucgacuccgg caaccccgcc      420

cccuccacca ccucccagca ggccaacucc caguccaccc ccgagcccuc ccccucccag      480

accuuccccg aguccgucgu cgccgagaag caguacuuca ucgagaagcu caccgccacc      540

aucuggaaga accucuccaa ccccgagaug accuccggcu ccgacaagau caacuacacc      600

uacaugcuca cccgcugcau ccaggccugc aagaccaacc ccgaguacau cuacgccccc      660

cucaaggaga ucccccccgc cgacaucccc aagaacaaga agcuccucac cgacggcuac      720

gccugcgagg uccgcugcca gaacaucuac cucaccaccg gcuacgccgg cuccaagaac      780

ggcucccgcg accgcgccac cgagcucgcc gucaagcucc uccagaagcg caucgagguc      840

cgcgucgucc gccgcaaguu caagcacacc uucggcgagg accucgucgu cugccagauc      900

ggcauguccu ccuacgaguu cccccccgcc cucaagcccc ccgaggaccu cgucguccuc      960

ggcaaggacg ccuccggcca gcccaucuuc aacgccuccg ccaagcacug gaccaacuuc     1020

gucaucaccg agaacgccaa cgacgccauc ggcauccuca acaacuccgc cuccuucaac     1080

aagaugucca ucgaguacaa guacgagaug augcccaacc gcaccuggcg cugccgcguc     1140

uuccuccagg accacugccu cgccgagggc uacggcacca agaagaccuc caagcacgcc     1200

gccgccgacg aggcccucaa gauccuccag aagacccagc ccaccuaccc cuccgucaag     1260

uccucccagu gccacaccgg cuccuccccc cgcggcuccg gcaagaagaa ggacaucaag     1320

gaccucgucg ucuacgagaa cuccuccaac cccgucugca cccucaacga caccgcccag     1380

uucaaccgca ugaccgucga guacgucuac gagcgcauga ccggccuccg cuggaagugc     1440

aaggucaucc ucgaguccga ggucaucgcc gaggccgucg gcgucaagaa gaccgucaag     1500

uacgaggccg ccggcgaggc cgucaagacc cucaagaaga cccagcccac cgucaucaac     1560

aaccucaaga agggcgccgu cgaggacguc aucucccgca acgagaucca gggccgcucc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucggcaacca gcuccuccgc     1680

aagaugggcu ggaccggcgg cggccucggc aaguccggcg agggcauccg cgagcccauc     1740

uccgucaagg agcagcacaa gcgcgagggc cucggccucg acgucgagcg cgucaacaag     1800

aucgccaagc gcgacaucga gcagaucauc cgcaacuacg cccgcuccga gucccacacc     1860

gaccucaccu ucucccgcga gcucaccaac gacgagcgca agcagaucca ccagaucgcc     1920

cagaaguacg gccucaaguc caagucccac ggcgucggcc acgaccgcua ccucgucguc     1980

ggccgcaagc gccgcaagga ggaccuccuc gaccagcuca agcaggaggg ccaggucggc     2040

cacuacgagc ucgucaugcc ccaggccaac uga                                  2073


<210>  9120
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NF-kappaB__Homo_sapiens__ABN11234

<400>  9120
auggagaaga uccugcagau ggccgaaggc auugacauag gggagaugcc cagcuacgau       60

cucgugcuuu ccaaaccuuc uaagggacag aaaagacacc ugucaaccug cgacggucaa      120

aacccaccga agaaacaggc uggcaguaag uuccaugcaa ggccccgguu ugaaccuguc      180

cacuucguug ccagcuccuc uaaggaugag gggcaggaag acccauaugg accccaaaca      240

aaagagguga augagcagac ucauuuugcg ucgaugccuc gcgauaucua ccaggacuau      300

acgcaggauu cauucagcau ucaagacggc aacagucagu acugugauuc cucugguuuu      360

aucuugacca aggaccagcc aguaacagcu aauauguauu ucgauagcgg gaaccccgcc      420

ccuuccacua ccucacagca agcaaauagu cagagcacac cagaaccguc ucccucccag      480

accuuuccug agucaguggu cgccgaaaaa caauacuuca uugagaaguu aacugcuaca      540

aucuggaaaa accugagcaa uccagagaug accaguggau cugacaagau aaacuauacg      600

uacaugcuaa cucgaugcau ccaggcaugu aagaccaauc ccgaauacau uuaugccccu      660

cucaaagaga ucccacccgc ugauauuccg aagaacaaaa agcugcuuac agacggcuac      720

gccugcgaag ugcguuguca gaauaucuau cugacuaccg gcuacgcggg guccaaaaac      780

ggaagcagag acagggcaac agaguuggcc guuaagcucc ugcagaaacg gauagaagug      840

cgcgucguga gaaggaaguu uaagcacacc uucggugagg aucugguagu uugccaaauu      900

ggcaugucgu cuuaugaguu uccucccgcu cucaaaccac cugaagacuu agugguccug      960

gggaaggaug ccuccggaca gcccaucuuc aaugcaucag cuaaacauug gacgaacuuu     1020

gugauuacug agaaugccaa cgacgcgauc ggcauccuua acaauagugc cagcuucaac     1080

aagaugucca uugaauacaa auaugagaug augccaaauc ggacauggcg cugucgagug     1140

uucuugcagg aucacugccu ggcagaaggu uacgggacca agaagacuuc uaaacacgcu     1200

gccgcugacg aggcccuaaa gauacuccag aaaacacaac ccaccuaccc uagcgucaag     1260

ucaagucagu gucauacggg auccagccca agaggcucug gcaaaaagaa ggauaucaaa     1320

gaccugguug uguaugagaa cucaaguaau ccgguaugca cccuuaacga uacagcacag     1380

uuuaauagga ugacugugga auacgucuau gagcggauga ccgggcugcg uuggaagugu     1440

aaagugauuu uggaaagcga gguuaucgcc gaagcugugg gagucaagaa aacagugaag     1500

uacgaggcgg ccggugaggc aguaaagacu cucaaaaaga cccagcccac aguuauaaac     1560

aaucugaaaa agggcgcugu ggaagacguc auuucccgca acgagaucca agggagaucu     1620

gccgaagagg cauauaaaca gcagaucaag gaggauaaua uuggaaacca guuacugagg     1680

aaaaugggcu ggaccggugg gggccucgga aagucgggcg aagggauccg ggagccuauu     1740

agcgugaagg aacaacacaa acgagaggga cuuggucugg acgucgaacg cgugaauaag     1800

auagccaaaa gagacaucga gcagauuauc aggaacuacg cucgguccga gucacauacu     1860

gauuugacgu ucagucgcga acuaacaaau gacgagagaa agcagaucca ccaaauugcc     1920

cagaaauaug gccugaaguc uaagagccac gggguuggac augauaggua ccucguggua     1980

ggccguaaac ggcgaaagga agaccugcuu gaucagcuga aacaggaggg ucaagucggg     2040

cacuacgaau uggugaugcc acaggcaaac uga                                  2073


<210>  9121
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NF-kappaB__Homo_sapiens__ABN11234

<400>  9121
auggagaaga uccugcagau ggccgagggc aucgacaucg gcgagaugcc cagcuacgac       60

cuggugcuga gcaagcccag caagggccag aagagacacc ugagcaccug cgacggccag      120

aaccccccca agaagcaggc cggcagcaag uuccacgcca gacccagauu cgagcccgug      180

cacuucgugg ccagcagcag caaggacgag ggccaggagg accccuacgg cccccagacc      240

aaggagguga acgagcagac ccacuucgcc agcaugccca gagacaucua ccaggacuac      300

acccaggaca gcuucagcau ccaggacggc aacagccagu acugcgacag cagcggcuuc      360

auccugacca aggaccagcc cgugaccgcc aacauguacu ucgacagcgg caaccccgcc      420

cccagcacca ccagccagca ggccaacagc cagagcaccc ccgagcccag ccccagccag      480

accuuccccg agagcguggu ggccgagaag caguacuuca ucgagaagcu gaccgccacc      540

aucuggaaga accugagcaa ccccgagaug accagcggca gcgacaagau caacuacacc      600

uacaugcuga ccagaugcau ccaggccugc aagaccaacc ccgaguacau cuacgccccc      660

cugaaggaga ucccccccgc cgacaucccc aagaacaaga agcugcugac cgacggcuac      720

gccugcgagg ugagaugcca gaacaucuac cugaccaccg gcuacgccgg cagcaagaac      780

ggcagcagag acagagccac cgagcuggcc gugaagcugc ugcagaagag aaucgaggug      840

agagugguga gaagaaaguu caagcacacc uucggcgagg accugguggu gugccagauc      900

ggcaugagca gcuacgaguu cccccccgcc cugaagcccc ccgaggaccu gguggugcug      960

ggcaaggacg ccagcggcca gcccaucuuc aacgccagcg ccaagcacug gaccaacuuc     1020

gugaucaccg agaacgccaa cgacgccauc ggcauccuga acaacagcgc cagcuucaac     1080

aagaugagca ucgaguacaa guacgagaug augcccaaca gaaccuggag augcagagug     1140

uuccugcagg accacugccu ggccgagggc uacggcacca agaagaccag caagcacgcc     1200

gccgccgacg aggcccugaa gauccugcag aagacccagc ccaccuaccc cagcgugaag     1260

agcagccagu gccacaccgg cagcagcccc agaggcagcg gcaagaagaa ggacaucaag     1320

gaccuggugg uguacgagaa cagcagcaac cccgugugca cccugaacga caccgcccag     1380

uucaacagaa ugaccgugga guacguguac gagagaauga ccggccugag auggaagugc     1440

aaggugaucc uggagagcga ggugaucgcc gaggccgugg gcgugaagaa gaccgugaag     1500

uacgaggccg ccggcgaggc cgugaagacc cugaagaaga cccagcccac cgugaucaac     1560

aaccugaaga agggcgccgu ggaggacgug aucagcagaa acgagaucca gggcagaagc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucggcaacca gcugcugaga     1680

aagaugggcu ggaccggcgg cggccugggc aagagcggcg agggcaucag agagcccauc     1740

agcgugaagg agcagcacaa gagagagggc cugggccugg acguggagag agugaacaag     1800

aucgccaaga gagacaucga gcagaucauc agaaacuacg ccagaagcga gagccacacc     1860

gaccugaccu ucagcagaga gcugaccaac gacgagagaa agcagaucca ccagaucgcc     1920

cagaaguacg gccugaagag caagagccac ggcgugggcc acgacagaua ccugguggug     1980

ggcagaaaga gaagaaagga ggaccugcug gaccagcuga agcaggaggg ccaggugggc     2040

cacuacgagc uggugaugcc ccaggccaac uga                                  2073


<210>  9122
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NF-kappaB__Homo_sapiens__ABN11234

<400>  9122
auggagaaga uccugcagau ggccgaaggc auugacaucg gggagaugcc cagcuacgau       60

cucgugcugu ccaaaccuuc uaagggacag aaaagacacc uuagcacaug cgacggccaa      120

aacccgccca agaaacaggc uggguccaag uuccaugccc ggccucgcuu ugaacccguc      180

cacuucguug cgucuagcuc caaggaugag ggacaggaag acccuuaugg cccccaaacc      240

aaagagguga augagcagac gcauuuugcu ucuaugccua gagauauuua ccaggacuau      300

acccaggaua gcuucuccau ccaagacggg aacagccagu acugugauuc uuccggauuu      360

auucugacaa aggaccagcc ggugaccgcc aauauguauu ucgauagcgg caaccccgcc      420

ccuucuacaa ccucccagca agcuaauagc cagucuacac ccgaaccuuc ccccagccag      480

accuuuccgg aguccgucgu ggccgaaaaa caauacuuca ucgagaagcu cacggcuacc      540

aucuggaaaa accugucuaa uccugagaug acaagcggcu ccgacaagau uaacuauacc      600

uacaugcuua cacggugcau ccaggccugu aagaccaauc ccgaauacau uuaugcgccu      660

cugaaagaga ucccucccgc cgauauuccc aagaacaaaa agcuccugac ggacggguac      720

gcuugcgaag uucgcuguca gaauaucuau cugacaaccg gauacgccgg cagcaaaaac      780

gggucuagag accgggcuac agagcucgcc gugaagcugc uucagaaacg cauugaaguc      840

agagugguuc ggcgcaaguu uaagcacacc uucggagagg aucugguggu cugccaaauc      900

ggcaugucca gcuaugaguu uccgcccgcg cucaaaccuc ccgaagaccu gguggugcuu      960

gggaaggaug ccucuggaca gccuaucuuc aaugcuagcg ccaaacauug gaccaacuuu     1020

gucauuacag agaaugcuaa cgacgccauc ggcauucuga acaauuccgc cucuuucaac     1080

aagaugagca ucgaauacaa auaugagaug augcccaaua gaacguggcg gugucgcguu     1140

uuccuccagg aucacugccu ggcugaaggc uacgggacca agaagacauc caaacacgcg     1200

gccgcugacg aggcccugaa gauucuccag aaaacccaac cgacauaccc uagcgugaag     1260

ucuucccagu gucauaccgg aagcucuccc agaggcuccg ggaaaaagaa ggauaucaaa     1320

gaccuggugg ucuaugagaa cagcuccaau ccugugugca cgcuuaacga uacagcccag     1380

uuuaaucgga ugaccguuga auacguguau gagcgcauga ccggacugag auggaagugu     1440

aaagucaucc ucgaaucuga ggugauugcu gaagccguug gcgugaagaa aacagucaag     1500

uacgaggcgg cuggggaggc cgugaagacc cugaaaaaga cacagcccac ggucaucaac     1560

aaucuuaaaa agggagccgu ggaagacguu auuagccgga acgagaucca aggcagaucc     1620

gcugaagagg ccuauaaaca gcagauuaag gaggauaaua ucggcaacca gcugcuccgc     1680

aaaauggggu ggaccggagg cgggcuggga aagucuggcg aagggauccg ggagccuauu     1740

agcgugaagg aacaacacaa aagagagggc cugggacucg acgucgaacg cgugaauaag     1800

aucgcuaaac gggacauuga gcagaucauu agaaacuacg cccgcuccga gagccauaca     1860

gaucugaccu ucucucggga acuuacaaau gacgagagaa agcagaucca ccaaauugcg     1920

cagaaauaug gccugaaguc caagagccac gggguuggac augaucgcua ccucgugguc     1980

ggccggaaaa gacgcaagga agaccugcuu gaucagcuga aacaggaggg gcaaguggga     2040

cacuacgaac ucgugaugcc ccaggccaac uga                                  2073


<210>  9123
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NF-kappaB__Homo_sapiens__A3F769

<400>  9123

Met Glu Lys Ile Leu Gln Met Ala Glu Gly Ile Asp Ile Gly Glu Met 
1               5                   10                  15      


Pro Ser Tyr Asp Leu Val Leu Ser Lys Pro Ser Lys Gly Gln Lys Arg 
            20                  25                  30          


His Leu Ser Thr Cys Asp Gly Gln Asn Pro Pro Lys Lys Gln Ala Gly 
        35                  40                  45              


Ser Lys Phe His Ala Arg Pro Arg Phe Glu Pro Val His Phe Val Ala 
    50                  55                  60                  


Ser Ser Ser Lys Asp Glu Arg Gln Glu Asp Pro Tyr Gly Pro Gln Thr 
65                  70                  75                  80  


Lys Glu Val Asn Glu Gln Thr His Phe Ala Ser Met Pro Arg Asp Ile 
                85                  90                  95      


Tyr Gln Asp Tyr Thr Gln Asp Ser Phe Ser Ile Gln Asp Gly Asn Ser 
            100                 105                 110         


Gln Tyr Cys Asp Ser Ser Gly Phe Ile Leu Thr Lys Asp Gln Pro Val 
        115                 120                 125             


Thr Ala Asn Met Tyr Phe Asp Ser Gly Asn Pro Ala Pro Ser Thr Thr 
    130                 135                 140                 


Ser Gln Gln Ala Asn Ser Gln Ser Thr Pro Glu Pro Ser Pro Ser Gln 
145                 150                 155                 160 


Thr Phe Pro Glu Ser Val Val Ala Glu Lys Gln Tyr Phe Ile Glu Lys 
                165                 170                 175     


Leu Thr Ala Thr Ile Trp Lys Asn Leu Ser Asn Pro Glu Met Thr Ser 
            180                 185                 190         


Gly Ser Asp Lys Ile Asn Tyr Thr Tyr Met Leu Thr Arg Cys Ile Gln 
        195                 200                 205             


Ala Cys Lys Thr Asn Pro Glu Tyr Ile Tyr Ala Pro Leu Lys Glu Ile 
    210                 215                 220                 


Pro Pro Ala Asp Ile Pro Lys Asn Lys Lys Leu Leu Thr Asp Gly Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Arg Cys Gln Asn Ile Tyr Leu Thr Thr Gly Tyr Ala 
                245                 250                 255     


Gly Ser Lys Asn Gly Ser Arg Asp Arg Ala Thr Glu Leu Ala Val Lys 
            260                 265                 270         


Leu Leu Gln Lys Arg Ile Glu Val Arg Val Val Arg Arg Lys Phe Lys 
        275                 280                 285             


His Thr Phe Gly Glu Asp Leu Val Val Cys Gln Ile Gly Met Ser Ser 
    290                 295                 300                 


Tyr Glu Phe Pro Pro Ala Leu Lys Pro Pro Glu Asp Leu Val Val Leu 
305                 310                 315                 320 


Gly Lys Asp Ala Ser Gly Gln Pro Ile Phe Asn Ala Ser Ala Lys His 
                325                 330                 335     


Trp Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile Gly Ile 
            340                 345                 350         


Leu Asn Asn Ser Ala Ser Phe Asn Lys Met Ser Ile Glu Tyr Lys Tyr 
        355                 360                 365             


Glu Met Met Pro Asn Arg Thr Trp Arg Cys Arg Val Phe Leu Gln Asp 
    370                 375                 380                 


His Cys Leu Ala Glu Gly Tyr Gly Thr Lys Lys Thr Ser Lys His Ala 
385                 390                 395                 400 


Ala Ala Asp Glu Ala Leu Lys Ile Leu Gln Lys Thr Gln Pro Thr Tyr 
                405                 410                 415     


Pro Ser Val Lys Ser Ser Gln Cys His Thr Gly Ser Ser Pro Arg Gly 
            420                 425                 430         


Ser Gly Lys Lys Lys Asp Ile Lys Asp Leu Val Val Tyr Glu Asn Ser 
        435                 440                 445             


Ser Asn Pro Val Cys Thr Leu Asn Asp Thr Ala Gln Phe Asn Arg Met 
    450                 455                 460                 


Thr Val Glu Tyr Val Tyr Glu Arg Met Thr Gly Leu Arg Trp Lys Cys 
465                 470                 475                 480 


Lys Val Ile Leu Glu Ser Glu Val Ile Ala Glu Ala Val Gly Val Lys 
                485                 490                 495     


Lys Thr Val Lys Tyr Glu Ala Ala Gly Glu Ala Val Lys Thr Leu Lys 
            500                 505                 510         


Lys Thr Gln Pro Thr Val Ile Asn Asn Leu Lys Lys Gly Ala Val Glu 
        515                 520                 525             


Asp Val Ile Ser Arg Asn Glu Ile Gln Gly Arg Ser Ala Glu Glu Ala 
    530                 535                 540                 


Tyr Lys Gln Gln Ile Lys Glu Asp Asn Ile Gly Asn Gln Leu Leu Arg 
545                 550                 555                 560 


Lys Met Gly Trp Thr Gly Gly Gly Leu Gly Lys Ser Gly Glu Gly Ile 
                565                 570                 575     


Arg Glu Pro Ile Ser Val Lys Glu Gln His Lys Arg Glu Gly Leu Gly 
            580                 585                 590         


Leu Asp Val Glu Arg Val Asn Lys Ile Ala Lys Arg Asp Ile Glu Gln 
        595                 600                 605             


Ile Ile Arg Asn Tyr Ala Arg Ser Glu Ser His Thr Asp Leu Thr Phe 
    610                 615                 620                 


Ser Arg Glu Leu Thr Asn Asp Glu Arg Lys Gln Ile His Gln Ile Ala 
625                 630                 635                 640 


Gln Lys Tyr Gly Leu Lys Ser Lys Ser His Gly Val Gly His Asp Arg 
                645                 650                 655     


Tyr Leu Val Val Gly Arg Lys Arg Arg Lys Glu Asp Leu Leu Asp Gln 
            660                 665                 670         


Leu Lys Gln Glu Gly Gln Val Gly His Tyr Glu Leu Val Met Pro Gln 
        675                 680                 685             


Ala Asn 
    690 


<210>  9124
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NF-kappaB__Homo_sapiens__ABN11235

<400>  9124
auggaaaaaa uucuccaaau ggcugaaggu auugauauug gggagaugcc uucauaugau       60

cuggugcugu ccaaaccuuc caaaggucaa aaacgccacc ucucaacaug ugauggucaa      120

aauccuccua aaaagcaagc cgguuccaaa uuccaugcga gaccucguuu ugagccugua      180

cauuuuguag cuaguaguuc aaaagaugaa agacaggaag auccuuaugg cccucaaaca      240

aaagagguaa augaacaaac acauuuugcc agcaugccaa gagacaucua ccaagauuau      300

acucaagacu cuuucaguau acaagauggg aauucucagu auugugauuc aucaggauuc      360

auucucacaa aagaccagcc uguaacagcc aacauguauu uugacagugg gaacccugcc      420

ccaagcacca caucacagca ggcaaacucu cagucaacuc cugagccuuc accaucacag      480

acauuucccg agucuguggu agccgagaag caguauuuua uugaaaaauu aacggcgaca      540

aucuggaaga accuuucuaa uccagaaaug acuucuggau cugauaaaau uaauuauaca      600

uauauguuaa cucguuguau ucaggcgugu aagacaaauc cugaguauau auaugcuccu      660

uuaaaggaaa uuccuccugc cgacaucccc aaaaauaaaa aacuucuaac ugauggcuau      720

gcuugugaag uuagaugcca aaauaucuac uuaacuacag guuaugcugg cagcaagaau      780

ggguccaggg aucgagcuac agagcuagcu guaaaacucu ugcagaaacg uauugaaguu      840

agaguugucc ggcggaaauu caagcauaca uuuggagagg accucguggu gugucagauu      900

ggcauguccu ccuaugaauu uccuccagcu cugaagccac cagaagaccu gguggugcug      960

gguaaagaug cuuccgggca gccaauuuuu aaugcuucug ccaaacacug gaccaauuuu     1020

gucauuacag aaaaugcaaa ugaugcaauu gguauccuua acaauucugc cucauucaac     1080

aagaugucaa uugaauacaa auaugagaug augccaaauc gcacauggcg uugucgagug     1140

uuuuuacaag aucacugcuu agcugaaggu uauggaacca agaaaacaag uaaacaugca     1200

gcugccgacg aggcuuugaa aauucuucaa aaaacacagc ccacuuaucc aucugucaaa     1260

aguucacaau gccauacagg cucuucaccc agaggaucug gaaagaagaa agauauaaag     1320

gaucuuguag uuuaugagaa uucuucaaau cccgugugca cgcugaacga cacagcucag     1380

uuuaaccgaa ugacaguuga guaugucuau gaaaggauga caggccuccg cuggaaaugc     1440

aaagugauuc uagagaguga aguaauugca gaagcaguug gggugaagaa aacugucaaa     1500

uaugaagcug cuggggaagc ugugaaaacc cucaaaaaga cccagccaac ugucauuaac     1560

aacuugaaga aaggagcugu ugaagaugug auuucaagaa augaaauuca gggccgcuca     1620

gcagaggagg cuuacaaaca gcaaaucaaa gaagauaaua uuggaaauca gcugcugaga     1680

aagauggguu ggacuggugg ugguuuaggu aaaucuggug agggcauacg ggagccuauc     1740

ucagugaaag agcagcauaa gcgggaaggg cuuggucugg auguagagag ggugaauaaa     1800

auugccaaga gagauauuga acagaucauc agaaacuacg cccgcuccga gagccacaca     1860

gauuugacuu ucucuagaga gcugacuaau gaugaacgga agcaaauaca ucagauugcc     1920

cagaaguaug gucuuaagag uaagucucau ggggugggcc augauaggua ccuaguggua     1980

gguagaaaaa gacggaagga agaccuacua gaucagcuca aacaggaagg ccaagugggc     2040

cauuacgagc uuguuaugcc ucaagcaaau uga                                  2073


<210>  9125
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NF-kappaB__Homo_sapiens__ABN11235

<400>  9125
auggagaaga uccugcagau ggccgagggc aucgacaucg gggagaugcc cagcuacgac       60

cucgugcugu ccaagccgag caagggccag aagcgccacc uguccacgug cgacgggcag      120

aacccgccca agaagcaggc cggcagcaag uuccacgcgc ggccccgcuu cgagcccguc      180

cacuucgugg ccuccagcuc caaggacgag cggcaggagg accccuacgg gccccagacc      240

aaggagguga acgagcagac ccacuucgcc agcaugcccc gcgacaucua ccaggacuac      300

acccaggacu ccuucagcau ccaggacggc aacucccagu acugcgacag cuccggcuuc      360

auccucacca aggaccagcc ggucaccgcc aacauguacu ucgacagcgg gaaccccgcc      420

cccuccacga ccagccagca ggcgaacucc cagagcaccc ccgagccguc ccccagccag      480

accuuccccg agagcguggu ggccgagaag caguacuuca ucgagaagcu gacggccacc      540

aucuggaaga accuguccaa ccccgagaug accagcggcu ccgacaagau caacuacacc      600

uacaugcuca cgcggugcau ccaggccugc aagaccaacc cggaguacau cuacgcgccc      660

cugaaggaga ucccgcccgc cgacaucccc aagaacaaga agcugcucac cgacggguac      720

gccugcgagg uccgcugcca gaacaucuac cugaccacgg gcuacgccgg gagcaagaac      780

ggcucccggg accgcgccac cgagcuggcg gugaagcucc ugcagaagcg gaucgaggug      840

cgcgucgugc ggcgcaaguu caagcacacc uucggcgagg accugguggu cugccagauc      900

gggaugagcu ccuacgaguu cccgcccgcc cucaagccgc ccgaggaccu gguggugcug      960

ggcaaggacg ccagcgggca gcccaucuuc aacgccuccg ccaagcacug gaccaacuuc     1020

gucaucacgg agaacgcgaa cgacgccauc ggcauccuca acaacagcgc cuccuucaac     1080

aagaugagca ucgaguacaa guacgagaug augcccaacc ggaccuggcg cugccgggug     1140

uuccugcagg accacugccu ggccgagggc uacgggacca agaagaccuc caagcacgcc     1200

gcggccgacg aggcccucaa gauccugcag aagacgcagc ccaccuaccc cagcgugaag     1260

uccagccagu gccacaccgg cuccagcccc cgcggguccg gcaagaagaa ggacaucaag     1320

gaccuggucg uguacgagaa cagcagcaac cccgugugca cccucaacga cacggcccag     1380

uucaaccgga ugaccgucga guacguguac gagcgcauga ccgggcugcg guggaagugc     1440

aaggugaucc uggaguccga ggucaucgcc gaggcggugg gcgucaagaa gaccgugaag     1500

uacgaggccg ccggcgaggc cgugaagacg cucaagaaga cccagccgac cgucaucaac     1560

aaccugaaga agggggcggu ggaggacgug aucagccgca acgagaucca gggccggucc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucgggaacca gcugcuccgc     1680

aagaugggcu ggaccggggg cggccugggc aagagcgggg aggggauccg cgagcccauc     1740

uccgucaagg agcagcacaa gcgggagggc cuggggcucg acguggagcg cgugaacaag     1800

aucgccaagc gggacaucga gcagaucauc cgcaacuacg cccggagcga gucccacacg     1860

gaccugaccu ucagccgcga gcugaccaac gacgagcgga agcagaucca ccagaucgcg     1920

cagaaguacg gccucaaguc caagagccac ggcgucgggc acgaccgcua ccugguggug     1980

ggccggaagc gccggaagga ggaccugcuc gaccagcuga agcaggaggg gcaggucggc     2040

cacuacgagc uggugaugcc ccaggccaac uga                                  2073


<210>  9126
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NF-kappaB__Homo_sapiens__ABN11235

<400>  9126
auggagaaga uccuccagau ggccgagggc aucgacaucg gcgagaugcc cuccuacgac       60

cucguccucu ccaagcccuc caagggccag aagcgccacc ucuccaccug cgacggccag      120

aaccccccca agaagcaggc cggcuccaag uuccacgccc gcccccgcuu cgagcccguc      180

cacuucgucg ccuccuccuc caaggacgag cgccaggagg accccuacgg cccccagacc      240

aaggagguca acgagcagac ccacuucgcc uccaugcccc gcgacaucua ccaggacuac      300

acccaggacu ccuucuccau ccaggacggc aacucccagu acugcgacuc cuccggcuuc      360

auccucacca aggaccagcc cgucaccgcc aacauguacu ucgacuccgg caaccccgcc      420

cccuccacca ccucccagca ggccaacucc caguccaccc ccgagcccuc ccccucccag      480

accuuccccg aguccgucgu cgccgagaag caguacuuca ucgagaagcu caccgccacc      540

aucuggaaga accucuccaa ccccgagaug accuccggcu ccgacaagau caacuacacc      600

uacaugcuca cccgcugcau ccaggccugc aagaccaacc ccgaguacau cuacgccccc      660

cucaaggaga ucccccccgc cgacaucccc aagaacaaga agcuccucac cgacggcuac      720

gccugcgagg uccgcugcca gaacaucuac cucaccaccg gcuacgccgg cuccaagaac      780

ggcucccgcg accgcgccac cgagcucgcc gucaagcucc uccagaagcg caucgagguc      840

cgcgucgucc gccgcaaguu caagcacacc uucggcgagg accucgucgu cugccagauc      900

ggcauguccu ccuacgaguu cccccccgcc cucaagcccc ccgaggaccu cgucguccuc      960

ggcaaggacg ccuccggcca gcccaucuuc aacgccuccg ccaagcacug gaccaacuuc     1020

gucaucaccg agaacgccaa cgacgccauc ggcauccuca acaacuccgc cuccuucaac     1080

aagaugucca ucgaguacaa guacgagaug augcccaacc gcaccuggcg cugccgcguc     1140

uuccuccagg accacugccu cgccgagggc uacggcacca agaagaccuc caagcacgcc     1200

gccgccgacg aggcccucaa gauccuccag aagacccagc ccaccuaccc cuccgucaag     1260

uccucccagu gccacaccgg cuccuccccc cgcggcuccg gcaagaagaa ggacaucaag     1320

gaccucgucg ucuacgagaa cuccuccaac cccgucugca cccucaacga caccgcccag     1380

uucaaccgca ugaccgucga guacgucuac gagcgcauga ccggccuccg cuggaagugc     1440

aaggucaucc ucgaguccga ggucaucgcc gaggccgucg gcgucaagaa gaccgucaag     1500

uacgaggccg ccggcgaggc cgucaagacc cucaagaaga cccagcccac cgucaucaac     1560

aaccucaaga agggcgccgu cgaggacguc aucucccgca acgagaucca gggccgcucc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucggcaacca gcuccuccgc     1680

aagaugggcu ggaccggcgg cggccucggc aaguccggcg agggcauccg cgagcccauc     1740

uccgucaagg agcagcacaa gcgcgagggc cucggccucg acgucgagcg cgucaacaag     1800

aucgccaagc gcgacaucga gcagaucauc cgcaacuacg cccgcuccga gucccacacc     1860

gaccucaccu ucucccgcga gcucaccaac gacgagcgca agcagaucca ccagaucgcc     1920

cagaaguacg gccucaaguc caagucccac ggcgucggcc acgaccgcua ccucgucguc     1980

ggccgcaagc gccgcaagga ggaccuccuc gaccagcuca agcaggaggg ccaggucggc     2040

cacuacgagc ucgucaugcc ccaggccaac uga                                  2073


<210>  9127
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NF-kappaB__Homo_sapiens__ABN11235

<400>  9127
auggagaaga uccugcagau ggccgaaggc auugacauag gggagaugcc cagcuacgau       60

cucgugcuuu ccaaaccuuc uaagggacag aaaagacacc ugucaaccug cgacggucaa      120

aacccaccga agaaacaggc uggcaguaag uuccaugcaa ggccccgguu ugaaccuguc      180

cacuucguug ccagcuccuc uaaggaugag cgccaggaag acccauaugg gccccaaaca      240

aaagagguga augagcagac ucauuuugcg ucgaugccuc gagauaucua ccaggacuau      300

acgcaggauu cauucagcau ucaagacgga aacagucagu acugugauuc cucuggcuuu      360

aucuugacca aggaccagcc aguaacagcu aauauguauu ucgauagcgg uaaccccgcc      420

ccuuccacua ccucacagca agcaaauagu cagagcacac cagaaccguc ucccucccag      480

accuuuccug agucaguggu cgccgaaaaa caauacuuca uugagaaguu aacugcuaca      540

aucuggaaaa accugagcaa uccagagaug accagugggu cugacaagau aaacuauacg      600

uacaugcuaa cucguugcau ccaggcaugu aagaccaauc ccgaauacau uuaugccccu      660

cucaaagaga ucccacccgc ugauauuccg aagaacaaaa agcugcuuac agacggauac      720

gccugcgaag ugagauguca gaauaucuau cugacuaccg gcuacgcggg cuccaaaaac      780

gggagcaggg accgggcaac agaguuggcc guuaagcucc ugcagaaacg cauagaagug      840

agagucguga ggcggaaguu uaagcacacc uucggagagg aucugguagu uugccaaauu      900

gguaugucgu cuuaugaguu uccucccgcu cucaaaccac cugaagacuu agugguccug      960

ggcaaggaug ccuccgggca gcccaucuuc aaugcaucag cuaaacauug gacgaacuuu     1020

gugauuacug agaaugccaa cgacgcgauc ggaauccuua acaauagugc cagcuucaac     1080

aagaugucca uugaauacaa auaugagaug augccaaauc gcacauggcg auguagagug     1140

uucuugcagg aucacugccu ggcagaaggc uacgguacca agaagacuuc uaaacacgcu     1200

gccgcugacg aggcccuaaa gauacuccag aaaacacaac ccaccuaccc uagcgucaag     1260

ucaagucagu gucauacggg guccagccca aggggaucug gcaaaaagaa ggauaucaaa     1320

gaccugguug uguaugagaa cucaaguaau ccgguaugca cccuuaacga uacagcacag     1380

uuuaaucgga ugacugugga auacgucuau gagcguauga ccggccugcg cuggaagugu     1440

aaagugauuu uggaaagcga gguuaucgcc gaagcugugg gggucaagaa aacagugaag     1500

uacgaggcgg caggagaggc cguaaagacu cucaaaaaga cccagcccac aguuauaaac     1560

aaucugaaaa agggugcugu ggaagacguc auuuccagaa acgagaucca aggcaggucu     1620

gccgaagagg cauauaaaca gcagaucaag gaggauaaua uugggaacca guuacugcgg     1680

aaaaugggau ggaccggcgg ugggcucggc aagucgggag aaggcauccg agagccuauu     1740

agcgugaagg aacaacacaa acgcgagggg cuuggacugg acgucgaaag agugaauaag     1800

auagccaaaa gggacaucga gcagauuauc cggaacuacg cucgcuccga gucacauacu     1860

gauuugacgu ucaguagaga acuaacaaau gacgagagga agcagaucca ccaaauugcc     1920

cagaaauaug gucugaaguc uaagagccac ggcguugggc augaucguua ccucguggua     1980

ggacggaaac gaagaaagga agaccugcuu gaucagcuga aacaggaggg ccaagucggu     2040

cacuacgaau uggugaugcc acaggcaaac uga                                  2073


<210>  9128
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NF-kappaB__Homo_sapiens__ABN11235

<400>  9128
auggagaaga uccugcagau ggccgagggc aucgacaucg gcgagaugcc cagcuacgac       60

cuggugcuga gcaagcccag caagggccag aagagacacc ugagcaccug cgacggccag      120

aaccccccca agaagcaggc cggcagcaag uuccacgcca gacccagauu cgagcccgug      180

cacuucgugg ccagcagcag caaggacgag agacaggagg accccuacgg cccccagacc      240

aaggagguga acgagcagac ccacuucgcc agcaugccca gagacaucua ccaggacuac      300

acccaggaca gcuucagcau ccaggacggc aacagccagu acugcgacag cagcggcuuc      360

auccugacca aggaccagcc cgugaccgcc aacauguacu ucgacagcgg caaccccgcc      420

cccagcacca ccagccagca ggccaacagc cagagcaccc ccgagcccag ccccagccag      480

accuuccccg agagcguggu ggccgagaag caguacuuca ucgagaagcu gaccgccacc      540

aucuggaaga accugagcaa ccccgagaug accagcggca gcgacaagau caacuacacc      600

uacaugcuga ccagaugcau ccaggccugc aagaccaacc ccgaguacau cuacgccccc      660

cugaaggaga ucccccccgc cgacaucccc aagaacaaga agcugcugac cgacggcuac      720

gccugcgagg ugagaugcca gaacaucuac cugaccaccg gcuacgccgg cagcaagaac      780

ggcagcagag acagagccac cgagcuggcc gugaagcugc ugcagaagag aaucgaggug      840

agagugguga gaagaaaguu caagcacacc uucggcgagg accugguggu gugccagauc      900

ggcaugagca gcuacgaguu cccccccgcc cugaagcccc ccgaggaccu gguggugcug      960

ggcaaggacg ccagcggcca gcccaucuuc aacgccagcg ccaagcacug gaccaacuuc     1020

gugaucaccg agaacgccaa cgacgccauc ggcauccuga acaacagcgc cagcuucaac     1080

aagaugagca ucgaguacaa guacgagaug augcccaaca gaaccuggag augcagagug     1140

uuccugcagg accacugccu ggccgagggc uacggcacca agaagaccag caagcacgcc     1200

gccgccgacg aggcccugaa gauccugcag aagacccagc ccaccuaccc cagcgugaag     1260

agcagccagu gccacaccgg cagcagcccc agaggcagcg gcaagaagaa ggacaucaag     1320

gaccuggugg uguacgagaa cagcagcaac cccgugugca cccugaacga caccgcccag     1380

uucaacagaa ugaccgugga guacguguac gagagaauga ccggccugag auggaagugc     1440

aaggugaucc uggagagcga ggugaucgcc gaggccgugg gcgugaagaa gaccgugaag     1500

uacgaggccg ccggcgaggc cgugaagacc cugaagaaga cccagcccac cgugaucaac     1560

aaccugaaga agggcgccgu ggaggacgug aucagcagaa acgagaucca gggcagaagc     1620

gccgaggagg ccuacaagca gcagaucaag gaggacaaca ucggcaacca gcugcugaga     1680

aagaugggcu ggaccggcgg cggccugggc aagagcggcg agggcaucag agagcccauc     1740

agcgugaagg agcagcacaa gagagagggc cugggccugg acguggagag agugaacaag     1800

aucgccaaga gagacaucga gcagaucauc agaaacuacg ccagaagcga gagccacacc     1860

gaccugaccu ucagcagaga gcugaccaac gacgagagaa agcagaucca ccagaucgcc     1920

cagaaguacg gccugaagag caagagccac ggcgugggcc acgacagaua ccugguggug     1980

ggcagaaaga gaagaaagga ggaccugcug gaccagcuga agcaggaggg ccaggugggc     2040

cacuacgagc uggugaugcc ccaggccaac uga                                  2073


<210>  9129
<211>  2073
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NF-kappaB__Homo_sapiens__ABN11235

<400>  9129
auggagaaga uccugcagau ggccgaaggc auugacaucg gggagaugcc cagcuacgau       60

cucgugcugu ccaaaccuuc uaagggacag aaaagacacc uuagcacaug cgacggccaa      120

aacccgccca agaaacaggc uggguccaag uuccaugccc ggccucgcuu ugaacccguc      180

cacuucguug cgucuagcuc caaggaugag agacaggaag acccuuaugg accccaaacc      240

aaagagguga augagcagac gcauuuugcu ucuaugccuc gggauauuua ccaggacuau      300

acccaggaua gcuucuccau ccaagacggc aacagccagu acugugauuc uuccggguuu      360

auucugacaa aggaccagcc ggugaccgcc aauauguauu ucgauagcgg aaaccccgcc      420

ccuucuacaa ccucccagca agcuaauagc cagucuacac ccgaaccuuc ccccagccag      480

accuuuccgg aguccgucgu ggccgaaaaa caauacuuca ucgagaagcu cacggcuacc      540

aucuggaaaa accugucuaa uccugagaug acaagcggcu ccgacaagau uaacuauacc      600

uacaugcuua cacgcugcau ccaggccugu aagaccaauc ccgaauacau uuaugcgccu      660

cugaaagaga ucccucccgc cgauauuccc aagaacaaaa agcuccugac ggacggcuac      720

gcuugcgaag uuagauguca gaauaucuau cugacaaccg gguacgccgg aagcaaaaac      780

ggcucucggg accgcgcuac agagcucgcc gugaagcugc uucagaaaag aauugaaguc      840

cgggugguuc gcagaaaguu uaagcacacc uucggggagg aucugguggu cugccaaauc      900

ggaaugucca gcuaugaguu uccgcccgcg cucaaaccuc ccgaagaccu gguggugcuu      960

ggcaaggaug ccucugggca gccuaucuuc aaugcuagcg ccaaacauug gaccaacuuu     1020

gucauuacag agaaugcuaa cgacgccauc ggcauucuga acaauuccgc cucuuucaac     1080

aagaugagca ucgaauacaa auaugagaug augcccaauc ggacguggcg cuguagaguu     1140

uuccuccagg aucacugccu ggcugaagga uacggcacca agaagacauc caaacacgcg     1200

gccgcugacg aggcccugaa gauucuccag aaaacccaac cgacauaccc uagcgugaag     1260

ucuucccagu gucauaccgg gagcucuccc cggggauccg gcaaaaagaa ggauaucaaa     1320

gaccuggugg ucuaugagaa cagcuccaau ccugugugca cgcuuaacga uacagcccag     1380

uuuaaucgca ugaccguuga auacguguau gagagaauga ccgggcugcg guggaagugu     1440

aaagucaucc ucgaaucuga ggugauugcu gaagccguug gagugaagaa aacagucaag     1500

uacgaggcgg cuggcgaggc cgugaagacc cugaaaaaga cacagcccac ggucaucaac     1560

aaucuuaaaa agggggccgu ggaagacguu auuagcagaa acgagaucca aggacgcucc     1620

gcugaagagg ccuauaaaca gcagauuaag gaggauaaua ucggcaacca gcugcuccgg     1680

aaaaugggcu ggaccggggg aggccugggg aagucuggag aaggcaucag agagccuauu     1740

agcgugaagg aacaacacaa acgcgagggg cugggccucg acgucgaacg ggugaauaag     1800

aucgcuaaaa gagacauuga gcagaucauu cgcaacuacg cccgguccga gagccauaca     1860

gaucugaccu ucucuagaga acuuacaaau gacgagcgca agcagaucca ccaaauugcg     1920

cagaaauaug gacugaaguc caagagccac ggcguugggc augaucggua ccucgugguc     1980

ggaagaaaac gccggaagga agaccugcuu gaucagcuga aacaggaggg ccaagugggg     2040

cacuacgaac ucgugaugcc ccaggccaac uga                                  2073


<210>  9130
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NLRP14__Homo_sapiens__Q86UT6

<400>  9130

Met Arg Trp Gly His His Leu Pro Arg Ala Ser Trp Gly Ser Gly Phe 
1               5                   10                  15      


Arg Arg Ala Leu Gln Arg Pro Asp Asp Arg Ile Pro Phe Leu Ile His 
            20                  25                  30          


Trp Ser Trp Pro Leu Gln Gly Glu Arg Pro Phe Gly Pro Pro Arg Ala 
        35                  40                  45              


Phe Ile Arg His His Gly Ser Ser Val Asp Ser Ala Pro Pro Pro Gly 
    50                  55                  60                  


Arg His Gly Arg Leu Phe Pro Ser Ala Ser Ala Thr Glu Ala Ile Gln 
65                  70                  75                  80  


Arg His Arg Arg Asn Leu Ala Glu Trp Phe Ser Arg Leu Pro Arg Glu 
                85                  90                  95      


Glu Arg Gln Phe Gly Pro Thr Phe Ala Leu Asp Thr Val His Val Asp 
            100                 105                 110         


Pro Val Ile Arg Glu Ser Thr Pro Asp Glu Leu Leu Arg Pro Pro Ala 
        115                 120                 125             


Glu Leu Ala Leu Glu His Gln Pro Pro Gln Ala Gly Leu Pro Pro Leu 
    130                 135                 140                 


Ala Leu Ser Gln Leu Phe Asn Pro Asp Ala Cys Gly Arg Arg Val Gln 
145                 150                 155                 160 


Thr Val Val Leu Tyr Gly Thr Val Gly Thr Gly Lys Ser Thr Leu Val 
                165                 170                 175     


Arg Lys Met Val Leu Asp Trp Cys Tyr Gly Arg Leu Pro Ala Phe Glu 
            180                 185                 190         


Leu Leu Ile Pro Phe Ser Cys Glu Asp Leu Ser Ser Leu Gly Pro Ala 
        195                 200                 205             


Pro Ala Ser Leu Cys Gln Leu Val Ala Gln Arg Tyr Thr Pro Leu Lys 
    210                 215                 220                 


Glu Val Leu Pro Leu Met Ala Ala Ala Gly Ser His Leu Leu Phe Val 
225                 230                 235                 240 


Leu His Gly Leu Glu His Leu Asn Leu Asp Phe Arg Leu Ala Gly Thr 
                245                 250                 255     


Gly Leu Cys Ser Asp Pro Glu Glu Pro Gln Glu Pro Ala Ala Ile Ile 
            260                 265                 270         


Val Asn Leu Leu Arg Lys Tyr Met Leu Pro Gln Ala Ser Ile Leu Val 
        275                 280                 285             


Thr Thr Arg Pro Ser Ala Ile Gly Arg Ile Pro Ser Lys Tyr Val Gly 
    290                 295                 300                 


Arg Tyr Gly Glu Ile Cys Gly Phe Ser Asp Thr Asn Leu Gln Lys Leu 
305                 310                 315                 320 


Tyr Phe Gln Leu Arg Leu Asn Gln Pro Tyr Cys Gly Tyr Ala Val Gly 
                325                 330                 335     


Gly Ser Gly Val Ser Ala Thr Pro Ala Gln Arg Asp His Leu Val Gln 
            340                 345                 350         


Met Leu Ser Arg Asn Leu Glu Gly His His Gln Ile Ala Ala Ala Cys 
        355                 360                 365             


Phe Leu Pro Ser Tyr Cys Trp Leu Val Cys Ala Thr Leu His Phe Leu 
    370                 375                 380                 


His Ala Pro Thr Pro Ala Gly Gln Thr Leu Thr Ser Ile Tyr Thr Ser 
385                 390                 395                 400 


Phe Leu Arg Leu Asn Phe Ser Gly Glu Thr Leu Asp Ser Thr Asp Pro 
                405                 410                 415     


Ser Asn Leu Ser Leu Met Ala Tyr Ala Ala Arg Thr Met Gly Lys Leu 
            420                 425                 430         


Ala Tyr Glu Gly Val Ser Ser Arg Lys Thr Tyr Phe Ser Glu Glu Asp 
        435                 440                 445             


Val Cys Gly Cys Leu Glu Ala Gly Ile Arg Thr Glu Glu Glu Phe Gln 
    450                 455                 460                 


Leu Leu His Ile Phe Arg Arg Asp Ala Leu Arg Phe Phe Leu Ala Pro 
465                 470                 475                 480 


Cys Val Glu Pro Gly Arg Ala Gly Thr Phe Val Phe Thr Val Pro Ala 
                485                 490                 495     


Met Gln Glu Tyr Leu Ala Ala Leu Tyr Ile Val Leu Gly Leu Arg Lys 
            500                 505                 510         


Thr Thr Leu Gln Lys Val Gly Lys Glu Val Ala Glu Leu Val Gly Arg 
        515                 520                 525             


Val Gly Glu Asp Val Ser Leu Val Leu Gly Ile Met Ala Lys Leu Leu 
    530                 535                 540                 


Pro Leu Arg Ala Leu Pro Leu Leu Phe Asn Leu Ile Lys Val Val Pro 
545                 550                 555                 560 


Arg Val Phe Gly Arg Met Val Gly Lys Ser Arg Glu Ala Val Ala Gln 
                565                 570                 575     


Ala Met Val Leu Glu Met Phe Arg Glu Glu Asp Tyr Tyr Asn Asp Asp 
            580                 585                 590         


Val Leu Asp Gln Met Gly Ala Ser Ile Leu Gly Val Glu Gly Pro Arg 
        595                 600                 605             


Arg His Pro Asp Glu Pro Pro Glu Asp Glu Val Phe Glu Leu Phe Pro 
    610                 615                 620                 


Met Phe Met Gly Gly Leu Leu Ser Ala His Asn Arg Ala Val Leu Ala 
625                 630                 635                 640 


Gln Leu Gly Cys Pro Ile Lys Asn Leu Asp Ala Leu Glu Asn Ala Gln 
                645                 650                 655     


Ala Ile Lys Lys Lys Leu Gly Lys Leu Gly Arg Gln Val Leu Pro Pro 
            660                 665                 670         


Ser Glu Leu Leu Asp His Leu Phe Phe His Tyr Glu Phe Gln Asn Gln 
        675                 680                 685             


Arg Phe Ser Ala Glu Val Leu Ser Ser Leu Arg Gln Leu Asn Leu Ala 
    690                 695                 700                 


Gly Val Arg Met Thr Pro Val Lys Cys Thr Val Val Ala Ala Val Leu 
705                 710                 715                 720 


Gly Ser Gly Arg His Ala Leu Asp Glu Val Asn Leu Ala Ser Cys Gln 
                725                 730                 735     


Leu Asp Pro Ala Gly Leu Arg Thr Leu Leu Pro Val Phe Leu Arg Ala 
            740                 745                 750         


Arg Lys Leu Gly Leu Gln Leu Asn Ser Leu Gly Pro Glu Ala Cys Lys 
        755                 760                 765             


Asp Leu Arg Asp Leu Leu Leu His Asp Gln Cys Gln Ile Thr Thr Leu 
    770                 775                 780                 


Arg Leu Ser Asn Asn Pro Leu Thr Ala Ala Gly Val Ala Val Leu Met 
785                 790                 795                 800 


Glu Gly Leu Ala Gly Asn Thr Ser Val Thr His Leu Ser Leu Leu His 
                805                 810                 815     


Thr Gly Leu Gly Asp Glu Gly Leu Glu Leu Leu Ala Ala Gln Leu Asp 
            820                 825                 830         


Arg Asn Arg Gln Leu Gln Glu Leu Asn Val Ala Tyr Asn Gly Ala Gly 
        835                 840                 845             


Asp Thr Ala Ala Leu Ala Leu Ala Arg Ala Ala Arg Glu His Pro Ser 
    850                 855                 860                 


Leu Glu Leu Leu His Leu Tyr Phe Asn Glu Leu Ser Ser Glu Gly Arg 
865                 870                 875                 880 


Gln Val Leu Arg Asp Leu Gly Gly Ala Ala Glu Gly Gly Ala Arg Val 
                885                 890                 895     


Val Val Ser Leu Thr Glu Gly Thr Ala Val Ser Glu Tyr Trp Ser Val 
            900                 905                 910         


Ile Leu Ser Glu Val Gln Arg Asn Leu Asn Ser Trp Asp Arg Ala Arg 
        915                 920                 925             


Val Gln Arg His Leu Glu Leu Leu Leu Arg Asp Leu Glu Asp Ser Arg 
    930                 935                 940                 


Gly Ala Thr Leu Asn Pro Trp Arg Lys Ala Gln Leu Leu Arg Val Glu 
945                 950                 955                 960 


Gly Glu Val Arg Ala Leu Leu Glu Gln Leu Gly Ser Ser Gly Ser 
                965                 970                 975 


<210>  9131
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NLRP14__Homo_sapiens__AAI10891

<400>  9131
augagguggg gccaccauuu gcccagggcc ucuuggggcu cugguuuuag aagagcacuc       60

cagcgaccag augaucguau ccccuuccug auccacugga guuggccccu ucaaggggag      120

cgucccuuug ggcccccuag ggccuuuaua cgccaccacg gaagcucggu agauagcgcu      180

cccccacccg ggaggcaugg acggcuguuc cccagcgccu cugcaacuga agcuauacag      240

cggcaccgcc ggaaccuggc ugagugguuc agccggcugc ccagggagga gcgccaguuu      300

ggcccaaccu uugcccuaga cacgguccac guugacccug ugauccgcga gaguaccccu      360

gaugagcuac uucgcccacc cgcggagcug gcccuggagc aucagccacc ccaggccggg      420

cuccccccac uggccuuguc ucagcucuuu aacccggaug ccugugggcg ccgggugcag      480

acaguggugc uguaugggac agugggcaca ggcaagagca cgcuggugcg caagaugguu      540

cuggacuggu guuaugggcg gcugccggcc uucgagcugc ucauccccuu cuccugugag      600

gaccugucau cccugggccc ugccccagcc ucccugugcc aacuuguggc ccagcgcuac      660

acgccccuga aggagguucu gccccugaug gcugcugcug ggucccaccu ccucuuugug      720

cuccauggcu uagagcaucu caaccucgac uuccggcugg caggcacggg acuuuguagu      780

gacccggagg aaccgcagga accagcugcu aucaucguca accugcugcg caaauacaug      840

cugccucagg ccagcauucu ggugaccacu cggcccucug ccauuggccg uauccccagc      900

aaguacgugg gccgcuaugg ugagaucugc gguuucucug auaccaaccu gcagaagcuc      960

uacuuccagc uccgccucaa ccagccguac ugcggguaug ccguuggcgg uucagguguc     1020

ucugccacac cagcucagcg ugaccaccug gugcagaugc ucucccggaa ccuggagggg     1080

caccaccaga uagccgcugc cugcuuccug ccguccuauu gcuggcucgu uugugccacc     1140

uugcacuucc ugcaugcccc cacgccugcu gggcagaccc uuacaagcau cuauaccagc     1200

uuccugcgcc ucaacuucag cggggaaacc cuggacagca cugaccccuc caauuugucc     1260

cugauggccu augcagcccg aaccaugggc aaguuggccu augagggggu guccucccgc     1320

aagaccuacu ucucugaaga ggaugucugu ggcugccugg aggcuggcau caggacggag     1380

gaggaguuuc agcugcugca caucuuccgu cgggaugccc ugagguuuuu ccuggcccca     1440

uguguggagc cagggcgugc aggcaccuuc guguucaccg ugcccgccau gcaggaauac     1500

cuggcugccc ucuacauugu gcuggguuug cgcaagacga cccugcaaaa ggugggcaag     1560

gaaguggcug agcucguggg ccguguuggg gaggacguca gccugguacu gggcaucaug     1620

gccaagcugc ugccucugcg ggcucugccu cugcucuuca accugaucaa ggugguucca     1680

cgaguguuug ggcgcauggu ggguaaaagc cgggaggcgg uggcucaggc cauggugcug     1740

gagauguuuc gagaggagga cuacuacaac gaugauguuc uggaccagau gggcgccagu     1800

auccugggcg uggagggccc ccggcgccac ccagaugagc ccccugagga ugaagucuuc     1860

gagcucuucc ccauguucau gggggggcuu cucucugccc acaaccgagc ugugcuagcu     1920

cagcuuggcu gccccaucaa gaaccuggau gcccuggaga augcccaggc caucaagaag     1980

aagcugggca agcugggccg gcaggugcug cccccaucag agcuccuuga ccaccucuuc     2040

uuccacuaug aguuccagaa ccagcgcuuc uccgcugagg ugcucagcuc ccugcgucag     2100

cucaaccugg caggugugcg caugacacca gucaagugca cagugguggc agcugugcug     2160

ggcagcggaa ggcaugcccu ggaugaggug aacuuggccu ccugccagcu agauccugcu     2220

gggcugcgca cacuccugcc ugucuuccug cgugcccgga agcugggcuu gcaacucaac     2280

agccugggcc cugaggccug caaggaccuc cgagaccugu ugcugcauga ccagugccaa     2340

auuaccacac ugcggcuguc caacaacccg cugacggcgg cagguguugc cgugcuaaug     2400

gaggggcugg caggaaacac cucagugacg caccuguccc ugcugcacac gggccuuggg     2460

gacgaaggcc uggagcugcu ggcugcccag cuggaccgca accggcagcu gcaggagcug     2520

aacguggcgu acaacggugc uggugacaca gcggcccugg cccuggccag agcugcccgg     2580

gagcacccuu cccuggaacu gcuacaccuc uacuucaaug agcugagcuc agagggccgc     2640

caggucuugc gagacuuggg gggugcugcu gaagguggug cccggguggu ggugucacug     2700

acagagggga cggcgguguc agaauacugg ucagugaucc ucagugaagu ccagcggaac     2760

cucaauagcu gggaucgggc ccggguucag cgacaccuug agcuccuacu gcgggaucug     2820

gaagauagcc ggggugccac ccuuaauccu uggcgcaagg cccagcugcu gcgaguggag     2880

ggcgagguca gggcccuccu ggagcagcug ggaagcucug gaagcuga                  2928


<210>  9132
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NLRP14__Homo_sapiens__AAI10891

<400>  9132
augcgcuggg gccaccaccu cccccgggcc agcugggggu ccggcuuccg ccgggcccug       60

cagcgcccgg acgaccggau ccccuuccug auccacugga gcuggccccu gcagggggag      120

cgccccuucg gcccgccccg ggcguucauc cgccaccacg gguccagcgu ggacuccgcc      180

ccgccgcccg gccggcacgg ccgccucuuc cccagcgccu ccgccaccga ggccauccag      240

cggcaccgcc ggaaccuggc ggagugguuc agccgccugc cccgggagga gcgccaguuc      300

gggcccaccu ucgcccucga cacgguccac guggaccccg ugauccggga guccaccccc      360

gacgagcugc ugcgcccgcc cgccgagcuc gcccuggagc accagccgcc ccaggcgggc      420

cugccgcccc ucgcccugag ccagcuguuc aaccccgacg ccugcgggcg gcgcguccag      480

accguggugc ucuacggcac cgucgggacg ggcaagucca cccuggugcg gaagauggug      540

cuggacuggu gcuacggccg ccuccccgcc uucgagcugc ugauccccuu cagcugcgag      600

gaccucucca gccuggggcc cgccccggcg ucccugugcc agcucgucgc ccagcgcuac      660

acgccccuga aggaggugcu gccccucaug gccgccgccg gcagccaccu ccuguucgug      720

cugcacgggc uggagcaccu gaaccucgac uuccggcugg cgggcaccgg ccugugcucc      780

gaccccgagg agccgcagga gcccgccgcc aucaucguca accuccugcg caaguacaug      840

cugccccagg ccagcauccu cgugaccacc cggccguccg ccaucgggcg cauccccagc      900

aaguacgugg gccgguacgg ggagaucugc ggcuucagcg acaccaaccu gcagaagcug      960

uacuuccagc uccgccugaa ccagcccuac ugcggguacg cggucggcgg cuccggggug     1020

agcgccaccc ccgcccagcg ggaccaccug gugcagaugc ucucccgcaa ccuggagggc     1080

caccaccaga ucgccgccgc gugcuuccug cccagcuacu gcuggcucgu cugcgccacg     1140

cugcacuucc ugcacgcccc cacccccgcc gggcagaccc ugaccuccau cuacacgagc     1200

uuccuccggc ugaacuucuc cggcgagacc cuggacagca ccgaccccuc caaccucagc     1260

cugauggcgu acgccgcccg caccaugggg aagcuggccu acgagggcgu guccagccgg     1320

aagacguacu ucuccgagga ggacgugugc ggcugccucg aggccgggau ccgcaccgag     1380

gaggaguucc agcugcugca caucuuccgg cgcgacgcgc uccgguucuu ccuggccccg     1440

ugcgucgagc ccggccgcgc cgggaccuuc guguucaccg ugcccgccau gcaggaguac     1500

cuggccgcgc ucuacaucgu ccugggccug cggaagacga cccuccagaa gguggggaag     1560

gaggucgccg agcugguggg ccgcgugggc gaggacguca gccuggugcu cgggaucaug     1620

gccaagcugc ugccccuccg ggcccugccg cuccuguuca accugaucaa gguggucccc     1680

cgcguguucg gccgcauggu ggggaagucc cgggaggccg ucgcgcaggc cauggugcug     1740

gagauguucc gcgaggagga cuacuacaac gacgacgugc ucgaccagau gggcgccagc     1800

auccugggcg ucgaggggcc ccggcgccac cccgacgagc cgcccgagga cgagguguuc     1860

gagcuguucc ccauguucau gggcgggcuc cuguccgccc acaaccgggc ggugcuggcc     1920

cagcucggcu gccccaucaa gaaccuggac gcccuggaga acgcccaggc caucaagaag     1980

aagcucggga agcugggccg ccagguccug ccgcccagcg agcuccugga ccaccuguuc     2040

uuccacuacg aguuccagaa ccagcgguuc uccgcggagg ugcucagcag ccugcgccag     2100

cugaaccucg ccggcgugcg gaugaccccc gucaagugca ccgugguggc cgccguccug     2160

ggguccggcc gccacgcccu ggacgaggug aaccucgcga gcugccagcu ggaccccgcc     2220

gggcugcgga cgcuccugcc gguguuccug cgcgcccgga agcucggccu gcagcugaac     2280

ucccucgggc ccgaggccug caaggaccug cgcgaccugc uccugcacga ccagugccag     2340

aucaccaccc ugcggcucag caacaacccc cugaccgccg cgggcgucgc cgugcugaug     2400

gagggccucg ccgggaacac guccgugacc caccugagcc ugcuccacac cggccugggg     2460

gacgagggcc uggagcuccu ggccgcgcag cuggaccgca accggcagcu ccaggagcug     2520

aacgucgccu acaacggggc cggcgacacc gccgcccugg cgcucgcccg cgccgcccgg     2580

gagcacccgu cccuggagcu gcuccaccug uacuucaacg agcugagcuc cgagggccgc     2640

caggugcucc gggaccucgg gggcgccgcg gagggcgggg cccgcguggu cgugagccug     2700

acggagggga ccgccguguc cgaguacugg agcgucaucc uguccgaggu gcagcgcaac     2760

cugaacagcu gggaccgggc ccgcgugcag cggcaccugg agcuccugcu gcgcgaccuc     2820

gaggacuccc ggggcgccac ccugaacccc uggcgcaagg cgcagcugcu gcgggucgag     2880

ggcgaggugc gcgcccuccu ggagcagcug gggagcuccg gcagcuga                  2928


<210>  9133
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NLRP14__Homo_sapiens__AAI10891

<400>  9133
augcgcuggg gccaccaccu cccccgcgcc uccuggggcu ccggcuuccg ccgcgcccuc       60

cagcgccccg acgaccgcau ccccuuccuc auccacuggu ccuggccccu ccagggcgag      120

cgccccuucg gccccccccg cgccuucauc cgccaccacg gcuccuccgu cgacuccgcc      180

cccccccccg gccgccacgg ccgccucuuc cccuccgccu ccgccaccga ggccauccag      240

cgccaccgcc gcaaccucgc cgagugguuc ucccgccucc cccgcgagga gcgccaguuc      300

ggccccaccu ucgcccucga caccguccac gucgaccccg ucauccgcga guccaccccc      360

gacgagcucc uccgcccccc cgccgagcuc gcccucgagc accagccccc ccaggccggc      420

cucccccccc ucgcccucuc ccagcucuuc aaccccgacg ccugcggccg ccgcguccag      480

accgucgucc ucuacggcac cgucggcacc ggcaagucca cccucguccg caagaugguc      540

cucgacuggu gcuacggccg ccuccccgcc uucgagcucc ucauccccuu cuccugcgag      600

gaccucuccu cccucggccc cgcccccgcc ucccucugcc agcucgucgc ccagcgcuac      660

accccccuca aggagguccu cccccucaug gccgccgccg gcucccaccu ccucuucguc      720

cuccacggcc ucgagcaccu caaccucgac uuccgccucg ccggcaccgg ccucugcucc      780

gaccccgagg agccccagga gcccgccgcc aucaucguca accuccuccg caaguacaug      840

cucccccagg ccuccauccu cgucaccacc cgccccuccg ccaucggccg cauccccucc      900

aaguacgucg gccgcuacgg cgagaucugc ggcuucuccg acaccaaccu ccagaagcuc      960

uacuuccagc uccgccucaa ccagcccuac ugcggcuacg ccgucggcgg cuccggcguc     1020

uccgccaccc ccgcccagcg cgaccaccuc guccagaugc ucucccgcaa ccucgagggc     1080

caccaccaga ucgccgccgc cugcuuccuc cccuccuacu gcuggcucgu cugcgccacc     1140

cuccacuucc uccacgcccc cacccccgcc ggccagaccc ucaccuccau cuacaccucc     1200

uuccuccgcc ucaacuucuc cggcgagacc cucgacucca ccgaccccuc caaccucucc     1260

cucauggccu acgccgcccg caccaugggc aagcucgccu acgagggcgu cuccucccgc     1320

aagaccuacu ucuccgagga ggacgucugc ggcugccucg aggccggcau ccgcaccgag     1380

gaggaguucc agcuccucca caucuuccgc cgcgacgccc uccgcuucuu ccucgccccc     1440

ugcgucgagc ccggccgcgc cggcaccuuc gucuucaccg uccccgccau gcaggaguac     1500

cucgccgccc ucuacaucgu ccucggccuc cgcaagacca cccuccagaa ggucggcaag     1560

gaggucgccg agcucgucgg ccgcgucggc gaggacgucu cccucguccu cggcaucaug     1620

gccaagcucc ucccccuccg cgcccucccc cuccucuuca accucaucaa ggucgucccc     1680

cgcgucuucg gccgcauggu cggcaagucc cgcgaggccg ucgcccaggc caugguccuc     1740

gagauguucc gcgaggagga cuacuacaac gacgacgucc ucgaccagau gggcgccucc     1800

auccucggcg ucgagggccc ccgccgccac cccgacgagc cccccgagga cgaggucuuc     1860

gagcucuucc ccauguucau gggcggccuc cucuccgccc acaaccgcgc cguccucgcc     1920

cagcucggcu gccccaucaa gaaccucgac gcccucgaga acgcccaggc caucaagaag     1980

aagcucggca agcucggccg ccagguccuc ccccccuccg agcuccucga ccaccucuuc     2040

uuccacuacg aguuccagaa ccagcgcuuc uccgccgagg uccucuccuc ccuccgccag     2100

cucaaccucg ccggcguccg caugaccccc gucaagugca ccgucgucgc cgccguccuc     2160

ggcuccggcc gccacgcccu cgacgagguc aaccucgccu ccugccagcu cgaccccgcc     2220

ggccuccgca cccuccuccc cgucuuccuc cgcgcccgca agcucggccu ccagcucaac     2280

ucccucggcc ccgaggccug caaggaccuc cgcgaccucc uccuccacga ccagugccag     2340

aucaccaccc uccgccucuc caacaacccc cucaccgccg ccggcgucgc cguccucaug     2400

gagggccucg ccggcaacac cuccgucacc caccucuccc uccuccacac cggccucggc     2460

gacgagggcc ucgagcuccu cgccgcccag cucgaccgca accgccagcu ccaggagcuc     2520

aacgucgccu acaacggcgc cggcgacacc gccgcccucg cccucgcccg cgccgcccgc     2580

gagcaccccu cccucgagcu ccuccaccuc uacuucaacg agcucuccuc cgagggccgc     2640

cagguccucc gcgaccucgg cggcgccgcc gagggcggcg cccgcgucgu cgucucccuc     2700

accgagggca ccgccgucuc cgaguacugg uccgucaucc ucuccgaggu ccagcgcaac     2760

cucaacuccu gggaccgcgc ccgcguccag cgccaccucg agcuccuccu ccgcgaccuc     2820

gaggacuccc gcggcgccac ccucaacccc uggcgcaagg cccagcuccu ccgcgucgag     2880

ggcgaggucc gcgcccuccu cgagcagcuc ggcuccuccg gcuccuga                  2928


<210>  9134
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NLRP14__Homo_sapiens__AAI10891

<400>  9134
augagauggg gccaccaucu gcccagggcc agcugggggu ccggauuccg gcgcgcucuc       60

cagcgaccug acgaucguau cccauuucuu auucacuggu cuuggccgcu gcaaggugag      120

agacccuucg gcccuccaag ggcauuuaua cggcaucacg ggucaagugu ggacagcgca      180

cccccuccag gacgccaugg cagauuguuc cccuccgcgu cugcuaccga agccauccag      240

aggcaccggc gcaacuuagc agagugguuu ucgcgacugc cuagagaaga gaggcaguuc      300

gguccaacau uugcccuaga uacuguccac guugacccgg ugauucggga aucaacgccc      360

gaugagcucc ugcguccucc agcugagcuu gcacuggaac aucagccccc ucaagccggg      420

uugccacccc ucgcucugag ccagcuguuc aauccggacg ccugcggacg cagaguacag      480

accguggucc ucuacggcac agugggcacu gggaagagua ccuuaguuag gaaaauggug      540

cuggauuggu guuauggacg gcuuccugcg uuugaguugc ugauccccuu cuccugcgaa      600

gaccuaucua gccucggucc agccccugcc ucccuguguc agcuugucgc ucaacgauac      660

acaccccuga aggagguguu gccacucaug gccgcagcug gcucacaccu guuauuugua      720

cugcaugggc ucgagcaccu uaaccuggau uuccgcuugg ccggaaccgg ccuaugcagu      780

gaccccgagg aaccucagga accagcggcc auuaucguua aucugcucag aaaauauaug      840

cugccgcagg caagcauacu ugugacuaca aggcccucug cuaucggucg gauuccuucc      900

aaguacgucg ggcgcuaugg agagaucugu ggcuuuucag auaccaaccu gcagaaauug      960

uacuuccaac ucagacugaa ucagccauau ugcggcuacg ccgucggggg aagcggugug     1020

agugcuacgc ccgcccagag ggaccacuua gugcaaaugc ugucucguaa ccuagaaggc     1080

caucaccaga uugcagccgc uuguuuccuc ccuuccuacu gcuggcuggu uugugcgacu     1140

cuucacuuuu ugcaugcacc aacccccgcc gggcagacac ugacuagcau cuauaccucg     1200

uuccuccggc ugaauuuuuc uggagagaca cuugauucca ccgacccguc aaaccugagu     1260

uugauggcuu acgccgcacg aacgaugggc aagcucgccu augagggugu gagcuccaga     1320

aagacuuacu ucucugaaga ggacguaugc gggugucugg aagcuggcau aaggacagag     1380

gaagaguuuc aguuacugca uauuuuccgc cgggaugccc uaagauuuuu ccucgcaccu     1440

ugcguggagc caggaagggc gggcaccuuu gucuucacug ugcccgcuau gcaagaauau     1500

cuggccgcac uuuacaucgu uuuggggcug cgcaaaacaa cccuccagaa ggugggaaaa     1560

gaggucgccg aacugguggg ucgaguaggc gaggacguua gcuuagugcu ggggauuaug     1620

gcuaaacuuu ugccucuccg ggcccugccc cuacuguuua aucucaucaa agucgugcca     1680

cgugucuucg gaagaauggu gggcaaguca agggaagcag uugcucaggc cauggugcug     1740

gagauguuuc gcgaggaaga uuauuacaac gacgauguac uugaccagau gggugcgagu     1800

aucuuggggg ucgagggccc ucggagacac cccgaugaac caccggagga cgagguguuc     1860

gaacuguucc cuauguuuau gggaggcuua cucuccgccc acaauagggc uguucuggca     1920

caacuugggu gccccauuaa gaaccuggau gccuuggaga augcucaggc cauaaagaag     1980

aaacucggaa agcugggucg acaggugcua ccacccagcg aacugcucga ccaucuguuc     2040

uuucacuacg aguuccagaa ccaacgcuuu ucugcagaag uccuuucaag uuugcggcag     2100

cugaauuuag cgggcgugag aaugacgccu guaaaaugua ccgugguugc cgcuguccuc     2160

gggagcggaa ggcaugcccu ggaugaggug aaccuugcau ccugccagcu ggacccagcu     2220

ggccuacgua cacuccugcc cguguucuug cgcgcccgga agcuggguuu acagcucaac     2280

ucucuggggc cugaggcaug uaaagaccuu agagaucugu ugcuccacga ccaaugccag     2340

aucacuaccc ugaggcuauc gaauaacccg cugacagccg cuggcgucgc gguucuuaug     2400

gaaggacucg ccggcaauac uagcgugacc caccuguccu ugcugcauac aggguuagga     2460

gaugagggcc ucgaacugcu ugcagcucag cuggaccgaa accggcaauu gcaggagcuc     2520

aauguggccu auaacggugc cggggauacc gcugcacugg cccuagcgcg cgcugccaga     2580

gaacacccau cacuggagcu ucuccaucug uacuuuaaug aguugaguuc ugaaggaagg     2640

cagguauuac gggaccuggg cggugcagcc gagggcgggg cucgagucgu gguuagccuc     2700

acugaaggaa cggcaguguc cgaguauugg ucagucauuc ugagcgaagu gcagagaaac     2760

cuuaauucuu gggaucgcgc caggguucaa cgucaccugg aguugcuacu gcgggaccuc     2820

gaggauucca gaggcgcgac acugaacccc uggaggaagg cucagcuuuu acgcguggaa     2880

ggggagguac gagcccugcu cgaacaguug ggaaguagcg gcucuuga                  2928


<210>  9135
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NLRP14__Homo_sapiens__AAI10891

<400>  9135
augagauggg gccaccaccu gcccagagcc agcuggggca gcggcuucag aagagcccug       60

cagagacccg acgacagaau ccccuuccug auccacugga gcuggccccu gcagggcgag      120

agacccuucg gcccccccag agccuucauc agacaccacg gcagcagcgu ggacagcgcc      180

cccccccccg gcagacacgg cagacuguuc cccagcgcca gcgccaccga ggccauccag      240

agacacagaa gaaaccuggc cgagugguuc agcagacugc ccagagagga gagacaguuc      300

ggccccaccu ucgcccugga caccgugcac guggaccccg ugaucagaga gagcaccccc      360

gacgagcugc ugagaccccc cgccgagcug gcccuggagc accagccccc ccaggccggc      420

cugccccccc uggcccugag ccagcuguuc aaccccgacg ccugcggcag aagagugcag      480

accguggugc uguacggcac cgugggcacc ggcaagagca cccuggugag aaagauggug      540

cuggacuggu gcuacggcag acugcccgcc uucgagcugc ugauccccuu cagcugcgag      600

gaccugagca gccugggccc cgcccccgcc agccugugcc agcugguggc ccagagauac      660

accccccuga aggaggugcu gccccugaug gccgccgccg gcagccaccu gcuguucgug      720

cugcacggcc uggagcaccu gaaccuggac uucagacugg ccggcaccgg ccugugcagc      780

gaccccgagg agccccagga gcccgccgcc aucaucguga accugcugag aaaguacaug      840

cugccccagg ccagcauccu ggugaccacc agacccagcg ccaucggcag aauccccagc      900

aaguacgugg gcagauacgg cgagaucugc ggcuucagcg acaccaaccu gcagaagcug      960

uacuuccagc ugagacugaa ccagcccuac ugcggcuacg ccgugggcgg cagcggcgug     1020

agcgccaccc ccgcccagag agaccaccug gugcagaugc ugagcagaaa ccuggagggc     1080

caccaccaga ucgccgccgc cugcuuccug cccagcuacu gcuggcuggu gugcgccacc     1140

cugcacuucc ugcacgcccc cacccccgcc ggccagaccc ugaccagcau cuacaccagc     1200

uuccugagac ugaacuucag cggcgagacc cuggacagca ccgaccccag caaccugagc     1260

cugauggccu acgccgccag aaccaugggc aagcuggccu acgagggcgu gagcagcaga     1320

aagaccuacu ucagcgagga ggacgugugc ggcugccugg aggccggcau cagaaccgag     1380

gaggaguucc agcugcugca caucuucaga agagacgccc ugagauucuu ccuggccccc     1440

ugcguggagc ccggcagagc cggcaccuuc guguucaccg ugcccgccau gcaggaguac     1500

cuggccgccc uguacaucgu gcugggccug agaaagacca cccugcagaa ggugggcaag     1560

gagguggccg agcugguggg cagagugggc gaggacguga gccuggugcu gggcaucaug     1620

gccaagcugc ugccccugag agcccugccc cugcuguuca accugaucaa gguggugccc     1680

agaguguucg gcagaauggu gggcaagagc agagaggccg uggcccaggc cauggugcug     1740

gagauguuca gagaggagga cuacuacaac gacgacgugc uggaccagau gggcgccagc     1800

auccugggcg uggagggccc cagaagacac cccgacgagc cccccgagga cgagguguuc     1860

gagcuguucc ccauguucau gggcggccug cugagcgccc acaacagagc cgugcuggcc     1920

cagcugggcu gccccaucaa gaaccuggac gcccuggaga acgcccaggc caucaagaag     1980

aagcugggca agcugggcag acaggugcug ccccccagcg agcugcugga ccaccuguuc     2040

uuccacuacg aguuccagaa ccagagauuc agcgccgagg ugcugagcag ccugagacag     2100

cugaaccugg ccggcgugag aaugaccccc gugaagugca ccgugguggc cgccgugcug     2160

ggcagcggca gacacgcccu ggacgaggug aaccuggcca gcugccagcu ggaccccgcc     2220

ggccugagaa cccugcugcc cguguuccug agagccagaa agcugggccu gcagcugaac     2280

agccugggcc ccgaggccug caaggaccug agagaccugc ugcugcacga ccagugccag     2340

aucaccaccc ugagacugag caacaacccc cugaccgccg ccggcguggc cgugcugaug     2400

gagggccugg ccggcaacac cagcgugacc caccugagcc ugcugcacac cggccugggc     2460

gacgagggcc uggagcugcu ggccgcccag cuggacagaa acagacagcu gcaggagcug     2520

aacguggccu acaacggcgc cggcgacacc gccgcccugg cccuggccag agccgccaga     2580

gagcacccca gccuggagcu gcugcaccug uacuucaacg agcugagcag cgagggcaga     2640

caggugcuga gagaccuggg cggcgccgcc gagggcggcg ccagaguggu ggugagccug     2700

accgagggca ccgccgugag cgaguacugg agcgugaucc ugagcgaggu gcagagaaac     2760

cugaacagcu gggacagagc cagagugcag agacaccugg agcugcugcu gagagaccug     2820

gaggacagca gaggcgccac ccugaacccc uggagaaagg cccagcugcu gagaguggag     2880

ggcgagguga gagcccugcu ggagcagcug ggcagcagcg gcagcuga                  2928


<210>  9136
<211>  2928
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NLRP14__Homo_sapiens__AAI10891

<400>  9136
augagauggg gccaccaucu gccccgggcc agcugggggu ccggauuccg cagagcucuc       60

cagcggccug acgaucgcau cccguuucug auucacuggu cuuggccccu ucaaggcgag      120

agaccuuucg ggcccccucg ggccuuuauc cgccaucacg gaagcuccgu ggacucugcg      180

cccccuccgg gcagacaugg gcggcuguuc cccagcgcuu ccgccaccga agccauucag      240

cgccacagac ggaaccucgc ugagugguuu ucucgccugc cuagagaaga acggcaguuc      300

ggacccacau uugcccuuga uacgguccac guugacccug ugauccgcga aagcaccccc      360

gaugagcugc ucagaccgcc ugcugagcug gcccuggaac aucagccccc ucaagcgggc      420

cucccucccc uggcccuuuc ccagcuguuc aaucccgacg cuugcggccg gagagugcag      480

acagucgugc ucuacgggac cguuggaaca ggcaagagca cccuggugcg caaaaugguc      540

cuugauuggu guuaugggcg gcugccggcc uuugagcucc ugauucccuu cucuugcgaa      600

gaccugucca gccucggacc ugcucccgcc ucucuguguc agcuuguggc gcaaagauac      660

acaccucuga aggagguucu cccccugaug gccgcugccg gcucccaccu ucuguuugug      720

cuccaugggc uggagcaccu gaaccucgau uuccgccugg cuggaaccgg ccuuugcagc      780

gacccggagg agccucagga acccgccgcc aucaucguca aucugcuccg gaaauauaug      840

cugccucagg cuucuauucu ugugacgacc agacccuccg cgaucggccg cauuccuagc      900

aaguacgugg ggcgguaugg agagaucugu ggcuuuuccg auacaaaccu gcagaaacuc      960

uacuuccaac ugagacugaa ucagcccuau ugcggguacg ccgucggagg cucugggguu     1020

agcgcuaccc cggcccagcg cgaccaccuc gugcaaaugc ugucccggaa ccuugaagga     1080

caucaccaga uugccgcugc cuguuuccug ccuagcuacu gcuggcucgu gugugcgaca     1140

cugcauuuuc ugcacgcucc cacccccgcc ggccagacgc uuacaucuau cuauaccucc     1200

uuccucagac ugaauuuuag cggcgagaca cuggauucua ccgacccuag caaccucucc     1260

cugauggccu acgcugcccg caccaugggg aagcuggcuu augagggagu cucuagccgg     1320

aagacauacu ucuccgaaga ggacgugugc ggcugucugg aagccgggau uagaacggag     1380

gaagaguuuc agcuccugca uaucuuccgg cgcgaugcgc ugagauuuuu ccuugccccg     1440

ugcguugagc ccggacgggc uggcaccuuu guguucacag ucccugccau gcaagaauau     1500

cucgcugccc uguacaucgu gcuggggcuc agaaaaacca cacugcagaa gguuggcaaa     1560

gagguggcgg aacuugucgg acgcgugggc gaggacguca gccuggugcu cgggauuaug     1620

gccaagcugc ugccccuucg ggcucucccu cugcuguuua aucucaucaa aguugugccc     1680

agagucuucg gacgcauggu gggcaagucu agagaagccg uugcucaggc cauggugcug     1740

gagauguuuc gggaggaaga uuauuacaac gacgaugucc uugaccagau gggggccucc     1800

auucugggag uggagggccc ucgcagacac cccgaugaac cgccugagga cgagguguuc     1860

gaacucuucc ccauguuuau gggcgggcug cugagcgcuc acaaucgggc gguucuugcc     1920

caacucggau gcccuaucaa gaaccuggau gcucuggaga augcccaggc cauuaaaaag     1980

aaacucggca agcuggggcg ccagguccuu cccccgucug aacugcucga ccaucuguuc     2040

uuucacuacg aguuccagaa ccaaagauuu uccgcugaag ugcugagcuc ccuucggcag     2100

cugaaucucg ccggagugcg caugaccccu gucaaaugua cggugguugc ggcugugcug     2160

ggcucuggga gacaugcccu cgaugagguc aaccuggcca gcugccagcu ugaccccgcu     2220

ggacugcgga cacuccugcc uguguuccug cgcgccagaa aacuuggccu gcagcucaac     2280

ucccuggggc ccgaggcgug uaaggaccuc cgggaucugc uucugcacga ccaaugccag     2340

aucaccaccc ucagacuguc uaauaacccc cugacagcug ccggcguugc cgugcuuaug     2400

gaaggacugg cuggcaauac cagcgucaca caccucuccc ugcuccauac ggggcuggga     2460

gaugagggcc uugaacugcu ggccgcucag cucgaccgca accggcaacu gcaggagcuu     2520

aauguggccu auaacggggc gggagauacc gccgcucugg cccucgcuag agccgcccgc     2580

gaacacccua gccuggagcu ccugcaucuu uacuuuaaug agcugucuuc cgaaggccgg     2640

cagguucuga gagaccucgg gggcgcugcg gagggaggcg cccgcguggu cgugagccug     2700

acagaaggga ccgcuguguc ugaguauugg uccgucaucc uuagcgaagu ucagcggaac     2760

cuuaauucuu gggauagagc ccgcgugcaa cggcaccucg agcugcuccu gagagaccuu     2820

gaggauagcc ggggagccac acugaacccg uggcgcaagg cucagcugcu cagaguggaa     2880

ggcgaggucc gggcccugcu ugaacagcug ggguccagcg gaucuuga                  2928


<210>  9137
<211>  1093
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NLRP14__Homo_sapiens__Q86W24

<400>  9137

Met Ala Asp Ser Ser Ser Ser Ser Phe Phe Pro Asp Phe Gly Leu Leu 
1               5                   10                  15      


Leu Tyr Leu Glu Glu Leu Asn Lys Glu Glu Leu Asn Thr Phe Lys Leu 
            20                  25                  30          


Phe Leu Lys Glu Thr Met Glu Pro Glu His Gly Leu Thr Pro Trp Asn 
        35                  40                  45              


Glu Val Lys Lys Ala Arg Arg Glu Asp Leu Ala Asn Leu Met Lys Lys 
    50                  55                  60                  


Tyr Tyr Pro Gly Glu Lys Ala Trp Ser Val Ser Leu Lys Ile Phe Gly 
65                  70                  75                  80  


Lys Met Asn Leu Lys Asp Leu Cys Glu Arg Ala Lys Glu Glu Ile Asn 
                85                  90                  95      


Trp Ser Ala Gln Thr Ile Gly Pro Asp Asp Ala Lys Ala Gly Glu Thr 
            100                 105                 110         


Gln Glu Asp Gln Glu Ala Val Leu Gly Asp Gly Thr Glu Tyr Arg Asn 
        115                 120                 125             


Arg Ile Lys Glu Lys Phe Cys Ile Thr Trp Asp Lys Lys Ser Leu Ala 
    130                 135                 140                 


Gly Lys Pro Glu Asp Phe His His Gly Ile Ala Glu Lys Asp Arg Lys 
145                 150                 155                 160 


Leu Leu Glu His Leu Phe Asp Val Asp Val Lys Thr Gly Ala Gln Pro 
                165                 170                 175     


Gln Ile Val Val Leu Gln Gly Ala Ala Gly Val Gly Lys Thr Thr Leu 
            180                 185                 190         


Val Arg Lys Ala Met Leu Asp Trp Ala Glu Gly Ser Leu Tyr Gln Gln 
        195                 200                 205             


Arg Phe Lys Tyr Val Phe Tyr Leu Asn Gly Arg Glu Ile Asn Gln Leu 
    210                 215                 220                 


Lys Glu Arg Ser Phe Ala Gln Leu Ile Ser Lys Asp Trp Pro Ser Thr 
225                 230                 235                 240 


Glu Gly Pro Ile Glu Glu Ile Met Tyr Gln Pro Ser Ser Leu Leu Phe 
                245                 250                 255     


Ile Ile Asp Ser Phe Asp Glu Leu Asn Phe Ala Phe Glu Glu Pro Glu 
            260                 265                 270         


Phe Ala Leu Cys Glu Asp Trp Thr Gln Glu His Pro Val Ser Phe Leu 
        275                 280                 285             


Met Ser Ser Leu Leu Arg Lys Val Met Leu Pro Glu Ala Ser Leu Leu 
    290                 295                 300                 


Val Thr Thr Arg Leu Thr Thr Ser Lys Arg Leu Lys Gln Leu Leu Lys 
305                 310                 315                 320 


Asn His His Tyr Val Glu Leu Leu Gly Met Ser Glu Asp Ala Arg Glu 
                325                 330                 335     


Glu Tyr Ile Tyr Gln Phe Phe Glu Asp Lys Arg Trp Ala Met Lys Val 
            340                 345                 350         


Phe Ser Ser Leu Lys Ser Asn Glu Met Leu Phe Ser Met Cys Gln Val 
        355                 360                 365             


Pro Leu Val Cys Trp Ala Ala Cys Thr Cys Leu Lys Gln Gln Met Glu 
    370                 375                 380                 


Lys Gly Gly Asp Val Thr Leu Thr Cys Gln Thr Thr Thr Ala Leu Phe 
385                 390                 395                 400 


Thr Cys Tyr Ile Ser Ser Leu Phe Thr Pro Val Asp Gly Gly Ser Pro 
                405                 410                 415     


Ser Leu Pro Asn Gln Ala Gln Leu Arg Arg Leu Cys Gln Val Ala Ala 
            420                 425                 430         


Lys Gly Ile Trp Thr Met Thr Tyr Val Phe Tyr Arg Glu Asn Leu Arg 
        435                 440                 445             


Arg Leu Gly Leu Thr Gln Ser Asp Val Ser Ser Phe Met Asp Ser Asn 
    450                 455                 460                 


Ile Ile Gln Lys Asp Ala Glu Tyr Glu Asn Cys Tyr Val Phe Thr His 
465                 470                 475                 480 


Leu His Val Gln Glu Phe Phe Ala Ala Met Phe Tyr Met Leu Lys Gly 
                485                 490                 495     


Ser Trp Glu Ala Gly Asn Pro Ser Cys Gln Pro Phe Glu Asp Leu Lys 
            500                 505                 510         


Ser Leu Leu Gln Ser Thr Ser Tyr Lys Asp Pro His Leu Thr Gln Met 
        515                 520                 525             


Lys Cys Phe Leu Phe Gly Leu Leu Asn Glu Asp Arg Val Lys Gln Leu 
    530                 535                 540                 


Glu Arg Thr Phe Asn Cys Lys Met Ser Leu Lys Ile Lys Ser Lys Leu 
545                 550                 555                 560 


Leu Gln Cys Met Glu Val Leu Gly Asn Ser Asp Tyr Ser Pro Ser Gln 
                565                 570                 575     


Leu Gly Phe Leu Glu Leu Phe His Cys Leu Tyr Glu Thr Gln Asp Lys 
            580                 585                 590         


Ala Phe Ile Ser Gln Ala Met Arg Cys Phe Pro Lys Val Ala Ile Asn 
        595                 600                 605             


Ile Cys Glu Lys Ile His Leu Leu Val Ser Ser Phe Cys Leu Lys His 
    610                 615                 620                 


Cys Arg Cys Leu Arg Thr Ile Arg Leu Ser Val Thr Val Val Phe Glu 
625                 630                 635                 640 


Lys Lys Ile Leu Lys Thr Ser Leu Pro Thr Asn Thr Trp Asp Gly Asp 
                645                 650                 655     


Arg Ile Thr His Cys Trp Gln Asp Leu Cys Ser Val Leu His Thr Asn 
            660                 665                 670         


Glu His Leu Arg Glu Leu Asp Leu Tyr His Ser Asn Leu Asp Lys Ser 
        675                 680                 685             


Ala Met Asn Ile Leu His His Glu Leu Arg His Pro Asn Cys Lys Leu 
    690                 695                 700                 


Gln Lys Leu Leu Leu Lys Phe Ile Thr Phe Pro Asp Gly Cys Gln Asp 
705                 710                 715                 720 


Ile Ser Thr Ser Leu Ile His Asn Lys Asn Leu Met His Leu Asp Leu 
                725                 730                 735     


Lys Gly Ser Asp Ile Gly Asp Asn Gly Val Lys Ser Leu Cys Glu Ala 
            740                 745                 750         


Leu Lys His Pro Glu Cys Lys Leu Gln Thr Leu Arg Leu Glu Ser Cys 
        755                 760                 765             


Asn Leu Thr Val Phe Cys Cys Leu Asn Ile Ser Asn Ala Leu Ile Arg 
    770                 775                 780                 


Ser Gln Ser Leu Ile Phe Leu Asn Leu Ser Thr Asn Asn Leu Leu Asp 
785                 790                 795                 800 


Asp Gly Val Gln Leu Leu Cys Glu Ala Leu Arg His Pro Lys Cys Tyr 
                805                 810                 815     


Leu Glu Arg Leu Ser Leu Glu Ser Cys Gly Leu Thr Glu Ala Gly Cys 
            820                 825                 830         


Glu Tyr Leu Ser Leu Ala Leu Ile Ser Asn Lys Arg Leu Thr His Leu 
        835                 840                 845             


Cys Leu Ala Asp Asn Val Leu Gly Asp Gly Gly Val Lys Leu Met Ser 
    850                 855                 860                 


Asp Ala Leu Gln His Ala Gln Cys Thr Leu Lys Ser Leu Val Leu Arg 
865                 870                 875                 880 


Arg Cys His Phe Thr Ser Leu Ser Ser Glu Tyr Leu Ser Thr Ser Leu 
                885                 890                 895     


Leu His Asn Lys Ser Leu Thr His Leu Asp Leu Gly Ser Asn Trp Leu 
            900                 905                 910         


Gln Asp Asn Gly Val Lys Leu Leu Cys Asp Val Phe Arg His Pro Ser 
        915                 920                 925             


Cys Asn Leu Gln Asp Leu Glu Leu Met Gly Cys Val Leu Thr Asn Ala 
    930                 935                 940                 


Cys Cys Leu Asp Leu Ala Ser Val Ile Leu Asn Asn Pro Asn Leu Arg 
945                 950                 955                 960 


Ser Leu Asp Leu Gly Asn Asn Asp Leu Gln Asp Asp Gly Val Lys Ile 
                965                 970                 975     


Leu Cys Asp Ala Leu Arg Tyr Pro Asn Cys Asn Ile Gln Arg Leu Gly 
            980                 985                 990         


Leu Glu Tyr Cys Gly Leu Thr Ser Leu Cys Cys Gln Asp Leu Ser Ser 
        995                 1000                1005            


Ala Leu Ile Cys Asn Lys Arg Leu Ile Lys Met Asn Leu Thr Gln Asn 
    1010                1015                1020                


Thr Leu Gly Tyr Glu Gly Ile Val Lys Leu Tyr Lys Val Leu Lys Ser 
1025                1030                1035                1040


Pro Lys Cys Lys Leu Gln Val Leu Gly Leu Cys Lys Glu Ala Phe Asp 
                1045                1050                1055    


Glu Glu Ala Gln Lys Leu Leu Glu Ala Val Gly Val Ser Asn Pro His 
            1060                1065                1070        


Leu Ile Ile Lys Pro Asp Cys Asn Tyr His Asn Glu Glu Asp Val Ser 
        1075                1080                1085            


Trp Trp Trp Cys Phe 
    1090            


<210>  9138
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NLRP14__Homo_sapiens__AAO18165

<400>  9138
auggcagauu caucaucauc uucuuucuuu ccugauuuug ggcugcuauu guauuuggag       60

gagcuaaaca aagaggaauu aaauacauuc aaguuauucc uaaaggagac cauggaaccu      120

gagcauggcc ugacacccug gaaugaagug aagaaggcca ggcgggagga ccuggccaau      180

uugaugaaga aauauuaucc aggagagaaa gccuggagug ugucucucaa aaucuuuggc      240

aagaugaacc ugaaggaucu gugugagaga gcgaaagaag agaucaacug gucggcccag      300

acuauaggac cagaugaugc caaggcugga gagacacaag aagaucagga ggcagugcug      360

ggugauggaa cagaauacag aaauagaaua aaggaaaaau uuugcaucac uugggacaag      420

aagucuuugg cuggaaagcc ugaagauuuc caucauggaa uugcagagaa agauagaaaa      480

cuguuggaac acuuguucga uguggauguc aaaaccggug cacagccaca gaucguggug      540

cuucagggag cugcuggagu ugggaaaaca accuugguga gaaaggcaau guuagauugg      600

gcagagggca gucucuacca gcagagguuu aaguauguuu uuuaucucaa ugggagagaa      660

auuaaccagc ugaaagagag aagcuuugcu caauugauau caaaggacug gcccagcaca      720

gaaggcccca uugaagaaau cauguaccag ccaaguagcc ucuuguuuau uauugacagu      780

uucgaugaac ugaacuuugc cuuugaagaa ccugaguuug cacugugcga agacuggacc      840

caagaacacc caguguccuu ccucaugagu aguuugcuga ggaaagugau gcucccugag      900

gcauccuuau uggugacaac aagacucaca acuucuaaga gacuaaagca guuguugaag      960

aaucaccauu auguagagcu acuaggaaug ucugaggaug caagagagga guauauuuac     1020

caguuuuuug aagauaagag gugggccaug aaaguauuca guucacuaaa aagcaaugag     1080

augcuguuua gcaugugcca agucccccua gugugcuggg ccgcuuguac uugucugaag     1140

cagcaaaugg agaagggugg ugaugucaca uugaccugcc aaacaaccac agcucuguuu     1200

accugcuaua uuucuagcuu guucacacca guagauggag gcucuccuag ucuacccaac     1260

caagcccagc ugagaagacu gugccaaguc gcugccaaag gaauauggac uaugacuuac     1320

guguuuuaca gagaaaaucu cagaaggcuu ggguuaacuc aaucugaugu cucuaguuuu     1380

auggacagca auauuauuca gaaggacgca gaguaugaaa acugcuaugu guucacccac     1440

cuucauguuc aggaguuuuu ugcagcuaug uucuauaugu ugaaaggcag uugggaagcu     1500

gggaacccuu ccugccagcc uuuugaagau uugaagucau uacuucaaag cacaaguuau     1560

aaagaccccc auuugacaca gaugaagugc uuuuuguuug gccuuuugaa ugaagaucga     1620

guaaaacaac uggagaggac uuuuaacugu aaaaugucac ugaagauaaa aucaaaguua     1680

cuucagugua uggaaguauu aggaaacagu gacuauucuc caucacagcu gggauuucug     1740

gaguuguuuc acugucugua ugagacucaa gauaaagcgu uuauaagcca ggcaaugaga     1800

uguuucccaa agguugccau uaauauuugu gagaaaauac auuugcuugu aucuucuuuc     1860

ugccuuaagc acugccggug uuugcggacc aucaggcugu cuguaacugu gguauuugag     1920

aagaagauau uaaaaacaag ccucccaacu aacacuuggg auggugaucg cauuacucac     1980

uguuggcaag aucucuguuc ugugcuucau acaaaugaac acuugagaga auuggaccug     2040

uaccauagca accuugauaa aucagcaaug aauauccugc aucaugaacu aaggcaccca     2100

aacuguaaac uacaaaagcu acuguugaaa uuuaucacuu ucccugaugg uugucaggau     2160

aucucuacuu cuuugauuca uaacaagaau cugaugcauc uugaccuaaa agggagugau     2220

auaggggaua auggaguaaa gucauugugu gaggccuuga aacacccaga guguaaacua     2280

cagacucuca ggcuggaauc uugcaaccua acuguauuuu guugucuaaa uauaucuaau     2340

gcucucauca gaagccagag ccugauauuu cugaaucugu caaccaauaa ucuguuggau     2400

gauggagugc agcuuuugug ugaggccuua agacauccaa aguguuaucu agagagacug     2460

uccuuagaaa gcuguggucu cacagaggcu ggcugugagu aucuuucuuu ggcucucauc     2520

agcaauaaaa gacugacaca uuugugcuug gcagacaaug ucuuggguga ugguggagua     2580

aagcuuauga gugaugcccu gcaacaugca caauguacuc ugaagagccu ugugcugagg     2640

cguugccauu ucacuucacu uagcagugaa uaucugucaa cuucucuucu acacaacaag     2700

agccugacgc aucuggaucu aggaucaaac uggcuacaag acaauggagu gaagcuucug     2760

ugugaugucu uucggcaucc aagcuguaau cuucaggacu uggaauugau gggcuguguu     2820

cucacuaaug cauguugucu ggaucuggcu ucuguuauuu ugaauaaccc aaaccugagg     2880

agccuggacc uugggaacaa cgauuugcag gaugauggag ugaaaauucu gugugaugcu     2940

uugagauauc caaacuguaa cauucagagg cucggguugg aauacugugg uuugacaucu     3000

cucugcuguc aagaucucuc cucugcucuu aucugcaaca aaagacugau aaaaaugaau     3060

cugacacaga auaccuuagg auaugaagga auugugaagu uauauaaagu cuugaagucu     3120

ccuaagugua aacuacaagu ucuaggguug ugcaaagagg cauuugauga ggaagcccag     3180

aagcugcugg aagcuguggg aguuagcaau ccacacuuaa ucauuaagcc agauuguaac     3240

uaucauaaug aagaagaugu gucuuggugg ugguguuucu ga                        3282


<210>  9139
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NLRP14__Homo_sapiens__AAO18165

<400>  9139
auggccgaca gcuccagcuc cagcuucuuc cccgacuucg gccugcuccu guaccuggag       60

gagcucaaca aggaggagcu gaacaccuuc aagcuguucc ucaaggagac cauggagccg      120

gagcacgggc ugacgcccug gaacgaggug aagaaggccc gccgggagga ccuggcgaac      180

cucaugaaga aguacuaccc cggcgagaag gccugguccg ucagccugaa gaucuucggg      240

aagaugaacc ugaaggaccu cugcgagcgc gccaaggagg agaucaacug guccgcccag      300

accaucggcc ccgacgacgc caaggcgggg gagacccagg aggaccagga ggccgugcug      360

ggcgacggca ccgaguaccg gaaccgcauc aaggagaagu ucugcaucac gugggacaag      420

aagucccugg ccgggaagcc ggaggacuuc caccacggca ucgccgagaa ggaccggaag      480

cuccuggagc accuguucga cguggacguc aagaccgggg cgcagcccca gaucguggug      540

cuccagggcg ccgccggggu cggcaagacc acccuggugc gcaaggccau gcuggacugg      600

gccgagggca gccucuacca gcagcgguuc aaguacgugu ucuaccugaa cgggcgcgag      660

aucaaccagc ugaaggagcg gagcuucgcg cagcucaucu ccaaggacug gcccagcacg      720

gagggcccca ucgaggagau cauguaccag ccguccagcc ugcuguucau caucgacucc      780

uucgacgagc ucaacuucgc cuucgaggag cccgaguucg cccugugcga ggacuggacc      840

caggagcacc ccgucagcuu ccugaugucc agccuccugc gcaaggugau gcugcccgag      900

gccucccucc uggugaccac ccggcugacg accagcaagc gccucaagca gcugcugaag      960

aaccaccacu acgucgagcu ccuggggaug agcgaggacg cccgggagga guacaucuac     1020

caguucuucg aggacaagcg cugggcgaug aagguguucu ccagccugaa guccaacgag     1080

augcuguuca gcaugugcca ggugccgcug gucugcuggg ccgccugcac gugccugaag     1140

cagcagaugg agaagggcgg cgacgugacc cugaccugcc agaccaccac cgcccucuuc     1200

acgugcuaca ucuccagccu guucaccccc guggacgggg gcucccccag ccuccccaac     1260

caggcccagc ugcggcgccu gugccagguc gcggccaagg ggaucuggac caugaccuac     1320

guguucuacc gggagaaccu gcgccggcuc ggccugacgc aguccgacgu gagcuccuuc     1380

auggacagca acaucaucca gaaggacgcc gaguacgaga acugcuacgu cuucacccac     1440

cuccacgugc aggaguucuu cgccgccaug uucuacaugc ucaagggguc cugggaggcg     1500

ggcaacccga gcugccagcc cuucgaggac cugaaguccc ugcuccagag caccuccuac     1560

aaggaccccc accugaccca gaugaagugc uuccuguucg gccuccugaa cgaggaccgc     1620

gugaagcagc uggagcggac guucaacugc aagaugagcc ucaagaucaa guccaagcug     1680

cugcagugca uggagguccu cgggaacagc gacuacagcc ccucccagcu gggcuuccug     1740

gagcuguucc acugccugua cgagacccag gacaaggccu ucaucagcca ggccaugcgc     1800

ugcuucccga agguggccau caacaucugc gagaagaucc accuccucgu cuccagcuuc     1860

ugccugaagc acugccgcug ccugcggacc auccgccucu ccgugaccgu ggucuucgag     1920

aagaagaucc ugaagacgag ccugcccacc aacaccuggg acggggaccg gaucacccac     1980

ugcuggcagg accucugcuc cgugcugcac acgaacgagc accuccgcga gcuggaccug     2040

uaccacagca accuggacaa guccgcgaug aacauccucc accacgagcu gcggcacccc     2100

aacugcaagc ugcagaagcu ccugcugaag uucaucaccu uccccgacgg cugccaggac     2160

aucagcaccu cccucaucca caacaagaac cugaugcacc uggaccucaa ggggagcgac     2220

aucggcgaca acggcgugaa gucccugugc gaggcccuga agcacccgga gugcaagcuc     2280

cagacccugc gccuggagag cugcaaccuc accgucuucu gcugccugaa caucuccaac     2340

gcccugaucc ggagccaguc ccucaucuuc cugaaccuga gcacgaacaa ccuccuggac     2400

gacggggugc agcugcucug cgaggcccug cgccacccca agugcuaccu ggagcggcuc     2460

agccuggagu ccugcggccu gaccgaggcc gggugcgagu accucagccu ggcgcugauc     2520

uccaacaagc gccucaccca ccugugccug gccgacaacg ugcucggcga cgggggcguc     2580

aagcugauga gcgacgcccu gcagcacgcc cagugcaccc ucaagucccu ggugcugcgg     2640

cgcugccacu ucacgagccu cuccagcgag uaccugucca ccagccugcu ccacaacaag     2700

ucccugaccc accuggaccu cggcagcaac uggcugcagg acaacggggu gaagcugcuc     2760

ugcgacgucu uccggcaccc cuccugcaac cugcaggacc uggagcucau gggcugcgug     2820

cugaccaacg ccugcugccu ggaccucgcg agcgugaucc ugaacaaccc caaccugcgc     2880

ucccucgacc uggggaacaa cgaccugcag gacgacggcg ucaagauccu gugcgacgcc     2940

cuccgguacc cgaacugcaa cauccagcgc cugggccugg aguacugcgg gcucacgagc     3000

cugugcugcc aggaccuguc cagcgcccuc aucugcaaca agcggcugau caagaugaac     3060

cugacccaga acacccucgg cuacgagggg aucgugaagc uguacaaggu gcugaagucc     3120

cccaagugca agcuccaggu ccugggccug ugcaaggagg ccuucgacga ggaggcccag     3180

aagcuccugg aggcgguggg ggugagcaac ccccaccuga ucaucaagcc ggacugcaac     3240

uaccacaacg aggaggacgu cagcuggugg uggugcuucu ga                        3282


<210>  9140
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NLRP14__Homo_sapiens__AAO18165

<400>  9140
auggccgacu ccuccuccuc cuccuucuuc cccgacuucg gccuccuccu cuaccucgag       60

gagcucaaca aggaggagcu caacaccuuc aagcucuucc ucaaggagac cauggagccc      120

gagcacggcc ucacccccug gaacgagguc aagaaggccc gccgcgagga ccucgccaac      180

cucaugaaga aguacuaccc cggcgagaag gccugguccg ucucccucaa gaucuucggc      240

aagaugaacc ucaaggaccu cugcgagcgc gccaaggagg agaucaacug guccgcccag      300

accaucggcc ccgacgacgc caaggccggc gagacccagg aggaccagga ggccguccuc      360

ggcgacggca ccgaguaccg caaccgcauc aaggagaagu ucugcaucac cugggacaag      420

aagucccucg ccggcaagcc cgaggacuuc caccacggca ucgccgagaa ggaccgcaag      480

cuccucgagc accucuucga cgucgacguc aagaccggcg cccagcccca gaucgucguc      540

cuccagggcg ccgccggcgu cggcaagacc acccucgucc gcaaggccau gcucgacugg      600

gccgagggcu cccucuacca gcagcgcuuc aaguacgucu ucuaccucaa cggccgcgag      660

aucaaccagc ucaaggagcg cuccuucgcc cagcucaucu ccaaggacug gcccuccacc      720

gagggcccca ucgaggagau cauguaccag cccuccuccc uccucuucau caucgacucc      780

uucgacgagc ucaacuucgc cuucgaggag cccgaguucg cccucugcga ggacuggacc      840

caggagcacc ccgucuccuu ccucaugucc ucccuccucc gcaaggucau gcuccccgag      900

gccucccucc ucgucaccac ccgccucacc accuccaagc gccucaagca gcuccucaag      960

aaccaccacu acgucgagcu ccucggcaug uccgaggacg cccgcgagga guacaucuac     1020

caguucuucg aggacaagcg cugggccaug aaggucuucu ccucccucaa guccaacgag     1080

augcucuucu ccaugugcca ggucccccuc gucugcuggg ccgccugcac cugccucaag     1140

cagcagaugg agaagggcgg cgacgucacc cucaccugcc agaccaccac cgcccucuuc     1200

accugcuaca ucuccucccu cuucaccccc gucgacggcg gcucccccuc ccuccccaac     1260

caggcccagc uccgccgccu cugccagguc gccgccaagg gcaucuggac caugaccuac     1320

gucuucuacc gcgagaaccu ccgccgccuc ggccucaccc aguccgacgu cuccuccuuc     1380

auggacucca acaucaucca gaaggacgcc gaguacgaga acugcuacgu cuucacccac     1440

cuccacgucc aggaguucuu cgccgccaug uucuacaugc ucaagggcuc cugggaggcc     1500

ggcaaccccu ccugccagcc cuucgaggac cucaaguccc uccuccaguc caccuccuac     1560

aaggaccccc accucaccca gaugaagugc uuccucuucg gccuccucaa cgaggaccgc     1620

gucaagcagc ucgagcgcac cuucaacugc aagauguccc ucaagaucaa guccaagcuc     1680

cuccagugca uggagguccu cggcaacucc gacuacuccc ccucccagcu cggcuuccuc     1740

gagcucuucc acugccucua cgagacccag gacaaggccu ucaucuccca ggccaugcgc     1800

ugcuucccca aggucgccau caacaucugc gagaagaucc accuccucgu cuccuccuuc     1860

ugccucaagc acugccgcug ccuccgcacc auccgccucu ccgucaccgu cgucuucgag     1920

aagaagaucc ucaagaccuc ccuccccacc aacaccuggg acggcgaccg caucacccac     1980

ugcuggcagg accucugcuc cguccuccac accaacgagc accuccgcga gcucgaccuc     2040

uaccacucca accucgacaa guccgccaug aacauccucc accacgagcu ccgccacccc     2100

aacugcaagc uccagaagcu ccuccucaag uucaucaccu uccccgacgg cugccaggac     2160

aucuccaccu cccucaucca caacaagaac cucaugcacc ucgaccucaa gggcuccgac     2220

aucggcgaca acggcgucaa gucccucugc gaggcccuca agcaccccga gugcaagcuc     2280

cagacccucc gccucgaguc cugcaaccuc accgucuucu gcugccucaa caucuccaac     2340

gcccucaucc gcucccaguc ccucaucuuc cucaaccucu ccaccaacaa ccuccucgac     2400

gacggcgucc agcuccucug cgaggcccuc cgccacccca agugcuaccu cgagcgccuc     2460

ucccucgagu ccugcggccu caccgaggcc ggcugcgagu accucucccu cgcccucauc     2520

uccaacaagc gccucaccca ccucugccuc gccgacaacg uccucggcga cggcggcguc     2580

aagcucaugu ccgacgcccu ccagcacgcc cagugcaccc ucaagucccu cguccuccgc     2640

cgcugccacu ucaccucccu cuccuccgag uaccucucca ccucccuccu ccacaacaag     2700

ucccucaccc accucgaccu cggcuccaac uggcuccagg acaacggcgu caagcuccuc     2760

ugcgacgucu uccgccaccc cuccugcaac cuccaggacc ucgagcucau gggcugcguc     2820

cucaccaacg ccugcugccu cgaccucgcc uccgucaucc ucaacaaccc caaccuccgc     2880

ucccucgacc ucggcaacaa cgaccuccag gacgacggcg ucaagauccu cugcgacgcc     2940

cuccgcuacc ccaacugcaa cauccagcgc cucggccucg aguacugcgg ccucaccucc     3000

cucugcugcc aggaccucuc cuccgcccuc aucugcaaca agcgccucau caagaugaac     3060

cucacccaga acacccucgg cuacgagggc aucgucaagc ucuacaaggu ccucaagucc     3120

cccaagugca agcuccaggu ccucggccuc ugcaaggagg ccuucgacga ggaggcccag     3180

aagcuccucg aggccgucgg cgucuccaac ccccaccuca ucaucaagcc cgacugcaac     3240

uaccacaacg aggaggacgu cuccuggugg uggugcuucu ga                        3282


<210>  9141
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NLRP14__Homo_sapiens__AAO18165

<400>  9141
auggccgaca gcuccucuuc aaguuucuuu cccgauuucg gccugcuccu uuaccuggag       60

gaauugaaca aggaggaauu aaauaccuuu aaacuguucc uaaaggagac aauggaaccu      120

gagcacgggc ucacuccaug gaacgaggug aaaaaggcua gaagggaaga ccuggcaaau      180

cuuaugaaaa aguauuaccc gggagagaag gccuggagcg ucucccugaa aaucuuuggu      240

aagaugaacu ugaaagaucu cugcgaacgg gcgaaggagg agauuaauug gucugcucag      300

acgauaggcc ccgacgaugc caaagcaggg gaaacccaag aggaccagga agccguucug      360

ggagauggca cagaguaucg caaccgaauc aaggaaaagu ucuguauuac uugggacaaa      420

aagucgcugg cugguaaacc ugaggauuuu caucacggga ucgcagagaa ggaccguaaa      480

cucuuagaac aucuguucga uguggacgua aagaccggag cccagccaca gauugugguc      540

cuucaaggcg cugccggcgu ggggaaaaca accuugguua gaaaggcgau gcuggauugg      600

gcagagggau cacuauacca gcagagguuu aaguaugugu ucuaccucaa uggucgggaa      660

aucaaccagc ugaaagagcg cagcuuugcc caacuuauaa guaaggacug gcccuccacu      720

gaaggcccua ucgaggagau uauguaucag ccaucuagcc uguuguucau cauugacucc      780

uuugaugaac ucaauuucgc uuucgaggaa cccgaguuug cccugugcga agacuggaca      840

caggagcacc cugucucauu cuuaaugagu agccugcuca gaaaagugau gcuuccagag      900

gcaucucugu ugguaaccac gaggcuaacu accuccaagc ggcugaaaca gcuccugaag      960

aaccaucacu acguugaacu ucuggggaug ucagaggaug cucgcgaaga guacaucuau     1020

caauuuuucg aggacaagcg augggccaug aaaguguuua gcaguuugaa gucuaaugaa     1080

augcuguucu ccauguguca ggucccgcuc gugugcuggg cggccuguac augcuuaaaa     1140

cagcaaaugg agaagggagg cgaugugacu cugaccuguc agacaaccac ggcacuauuu     1200

acuugcuaca uaagcucucu cuucacaccc gucgacggug ggucgccuuc ccugccaaac     1260

caggcucagc uuagaagguu gugucaaguu gccgcuaaag gaauuuggac caugacuuau     1320

guguuuuacc gggaaaaucu gcgucgccuc ggccugacac agucagaugu aaguagcuuc     1380

auggacucca acaucauuca gaaggaugcc gaguaugaaa auugcuacgu guuuacccac     1440

cuucaugucc aggaguucuu ugcagccaug uucuauaugc ugaagggcuc uugggaggcu     1500

gggaacccca gcugucaacc uuucgaagac uugaaaucac uccugcagag uacguccuac     1560

aaggauccac acuuaaccca gaugaaaugc uuucuguucg gacuacucaa cgaggacaga     1620

gugaagcagc uggaaaggac auuuaauugc aaaaugagcc uuaagaucaa gucuaaauug     1680

cugcaaugua uggagguucu cgguaacuca gacuacaguc ccagccagcu gggcuucuua     1740

gaacuguuuc auugccuuua ugagacucag gauaaggcgu ucaucuccca ggcaaugcgg     1800

uguuuuccga aaguggccau uaauauaugc gagaagaucc acuugcucgu cucuucguuc     1860

ugucugaaac acugccgaug ucuacgcacc auuagacuga gcgugacagu aguuuuugaa     1920

aagaaaaucc ucaagacuuc ccugccuacc aacacauggg acggggauag gauaacccau     1980

ugcuggcaag accuuuguuc aguguugcac acuaaugagc aucugcggga auuagaucuc     2040

uaccacagua accuggacaa gucugcuaug aauauucuuc aucacgagcu gcgccacccc     2100

aacugcaaau ugcagaagcu ccugcuaaaa uucaucacgu uuccagaugg augucaggac     2160

aucagcacau cccugauuca uaauaagaac cucaugcacc uggaucuuaa aggcucagac     2220

aucggugaua auggggucaa gagcuugugc gaagcccuga agcauccuga gugcaaauua     2280

caaacccuca gacuggaguc uuguaaccuu acuguguucu gcugucugaa uauuuccaac     2340

gcacuaauaa ggagucagag ccucaucuuu cugaauuugu cuaccaacaa ccuguuagac     2400

gauggcgucc agcuccugug cgaagcccuu cgucacccca aguguuaucu ggagcgguug     2460

ucccucgaau caugcggacu gacagaggcu ggcugugagu accuaagucu ggcccuuauu     2520

agcaauaaac gacucaccca ccugugcuug gcagacaacg ugcuggggga cggagguguu     2580

aaguuaaugu cggaugcgcu ccagcaugcu caauguacuc ugaaaucccu ugugcugaga     2640

aggugccacu ucacaucuuu gagcucagaa uaucucagua cgucccugcu acauaauaag     2700

ucucugaccc accuugaccu cggcagcaac uggcugcagg auaauggggu aaaguuguua     2760

ugugacgucu uccgccaucc auccugcaac cugcaggauc ucgagcugau gggaugcgug     2820

cuuacuaaug ccuguugccu ggacuuggca ucaguuaucc uaaacaaucc caaccugcgg     2880

agccucgauc ugggcaauaa cgaccuucag gaugacggug ugaaaaucuu augugaugcc     2940

cugagauacc cuaauugcaa cauucaaagg cucggguugg aauauugugg ccugacaagu     3000

cucugcuguc aggaccuguc uuccgcucuu auaugcaaua agcgccugau caaaaugaac     3060

uugacccaga acacacuagg auacgagggc auugucaagc uguacaaagu gcucaagagc     3120

ccaaagugua aauuacaggu acuggggcuu ugcaaggaag ccuuugauga ggaggcacaa     3180

aaacugcucg aagcuguggg aguuucgaau ccgcacuuga ucauuaagcc cgacuguaac     3240

uaucacaaug aggaagacgu cucauggugg uggugcuucu ga                        3282


<210>  9142
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NLRP14__Homo_sapiens__AAO18165

<400>  9142
auggccgaca gcagcagcag cagcuucuuc cccgacuucg gccugcugcu guaccuggag       60

gagcugaaca aggaggagcu gaacaccuuc aagcuguucc ugaaggagac cauggagccc      120

gagcacggcc ugacccccug gaacgaggug aagaaggcca gaagagagga ccuggccaac      180

cugaugaaga aguacuaccc cggcgagaag gccuggagcg ugagccugaa gaucuucggc      240

aagaugaacc ugaaggaccu gugcgagaga gccaaggagg agaucaacug gagcgcccag      300

accaucggcc ccgacgacgc caaggccggc gagacccagg aggaccagga ggccgugcug      360

ggcgacggca ccgaguacag aaacagaauc aaggagaagu ucugcaucac cugggacaag      420

aagagccugg ccggcaagcc cgaggacuuc caccacggca ucgccgagaa ggacagaaag      480

cugcuggagc accuguucga cguggacgug aagaccggcg cccagcccca gaucguggug      540

cugcagggcg ccgccggcgu gggcaagacc acccugguga gaaaggccau gcuggacugg      600

gccgagggca gccuguacca gcagagauuc aaguacgugu ucuaccugaa cggcagagag      660

aucaaccagc ugaaggagag aagcuucgcc cagcugauca gcaaggacug gcccagcacc      720

gagggcccca ucgaggagau cauguaccag cccagcagcc ugcuguucau caucgacagc      780

uucgacgagc ugaacuucgc cuucgaggag cccgaguucg cccugugcga ggacuggacc      840

caggagcacc ccgugagcuu ccugaugagc agccugcuga gaaaggugau gcugcccgag      900

gccagccugc uggugaccac cagacugacc accagcaaga gacugaagca gcugcugaag      960

aaccaccacu acguggagcu gcugggcaug agcgaggacg ccagagagga guacaucuac     1020

caguucuucg aggacaagag augggccaug aagguguuca gcagccugaa gagcaacgag     1080

augcuguuca gcaugugcca ggugccccug gugugcuggg ccgccugcac cugccugaag     1140

cagcagaugg agaagggcgg cgacgugacc cugaccugcc agaccaccac cgcccuguuc     1200

accugcuaca ucagcagccu guucaccccc guggacggcg gcagccccag ccugcccaac     1260

caggcccagc ugagaagacu gugccaggug gccgccaagg gcaucuggac caugaccuac     1320

guguucuaca gagagaaccu gagaagacug ggccugaccc agagcgacgu gagcagcuuc     1380

auggacagca acaucaucca gaaggacgcc gaguacgaga acugcuacgu guucacccac     1440

cugcacgugc aggaguucuu cgccgccaug uucuacaugc ugaagggcag cugggaggcc     1500

ggcaacccca gcugccagcc cuucgaggac cugaagagcc ugcugcagag caccagcuac     1560

aaggaccccc accugaccca gaugaagugc uuccuguucg gccugcugaa cgaggacaga     1620

gugaagcagc uggagagaac cuucaacugc aagaugagcc ugaagaucaa gagcaagcug     1680

cugcagugca uggaggugcu gggcaacagc gacuacagcc ccagccagcu gggcuuccug     1740

gagcuguucc acugccugua cgagacccag gacaaggccu ucaucagcca ggccaugaga     1800

ugcuucccca agguggccau caacaucugc gagaagaucc accugcuggu gagcagcuuc     1860

ugccugaagc acugcagaug ccugagaacc aucagacuga gcgugaccgu gguguucgag     1920

aagaagaucc ugaagaccag ccugcccacc aacaccuggg acggcgacag aaucacccac     1980

ugcuggcagg accugugcag cgugcugcac accaacgagc accugagaga gcuggaccug     2040

uaccacagca accuggacaa gagcgccaug aacauccugc accacgagcu gagacacccc     2100

aacugcaagc ugcagaagcu gcugcugaag uucaucaccu uccccgacgg cugccaggac     2160

aucagcacca gccugaucca caacaagaac cugaugcacc uggaccugaa gggcagcgac     2220

aucggcgaca acggcgugaa gagccugugc gaggcccuga agcaccccga gugcaagcug     2280

cagacccuga gacuggagag cugcaaccug accguguucu gcugccugaa caucagcaac     2340

gcccugauca gaagccagag ccugaucuuc cugaaccuga gcaccaacaa ccugcuggac     2400

gacggcgugc agcugcugug cgaggcccug agacacccca agugcuaccu ggagagacug     2460

agccuggaga gcugcggccu gaccgaggcc ggcugcgagu accugagccu ggcccugauc     2520

agcaacaaga gacugaccca ccugugccug gccgacaacg ugcugggcga cggcggcgug     2580

aagcugauga gcgacgcccu gcagcacgcc cagugcaccc ugaagagccu ggugcugaga     2640

agaugccacu ucaccagccu gagcagcgag uaccugagca ccagccugcu gcacaacaag     2700

agccugaccc accuggaccu gggcagcaac uggcugcagg acaacggcgu gaagcugcug     2760

ugcgacgugu ucagacaccc cagcugcaac cugcaggacc uggagcugau gggcugcgug     2820

cugaccaacg ccugcugccu ggaccuggcc agcgugaucc ugaacaaccc caaccugaga     2880

agccuggacc ugggcaacaa cgaccugcag gacgacggcg ugaagauccu gugcgacgcc     2940

cugagauacc ccaacugcaa cauccagaga cugggccugg aguacugcgg ccugaccagc     3000

cugugcugcc aggaccugag cagcgcccug aucugcaaca agagacugau caagaugaac     3060

cugacccaga acacccuggg cuacgagggc aucgugaagc uguacaaggu gcugaagagc     3120

cccaagugca agcugcaggu gcugggccug ugcaaggagg ccuucgacga ggaggcccag     3180

aagcugcugg aggccguggg cgugagcaac ccccaccuga ucaucaagcc cgacugcaac     3240

uaccacaacg aggaggacgu gagcuggugg uggugcuucu ga                        3282


<210>  9143
<211>  3282
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NLRP14__Homo_sapiens__AAO18165

<400>  9143
auggccgaca gcuccucuag cuccuucuuu cccgauuucg gccugcuccu guaccuugag       60

gaacugaaca aggaggaacu caauaccuuu aaacuguucc uuaaggagac aauggaaccu      120

gagcacgggc ugacgccgug gaacgaggug aaaaaggcua gacgggaaga ccucgccaau      180

cugaugaaaa aguauuaccc cggagagaag gcguggucug ucagccugaa aaucuuuggc      240

aagaugaacc ucaaagaucu gugcgaacgc gcuaaggagg agauuaauug guccgcccag      300

accaucgggc cugacgaugc caaagcugga gaaacacaag aggaccagga agccguucuu      360

ggcgauggga ccgaguauag aaaccggauu aaggaaaagu ucuguaucac augggacaaa      420

aagucucugg cuggaaaacc cgaggauuuu caucacggca uugccgagaa ggaccgcaaa      480

cuccuggaac aucuuuucga uguggacgug aagaccggcg cgcagccuca gaucgucgug      540

cugcaagggg ccgcuggagu uggcaaaaca acccucguga gaaaggccau gcuggauugg      600

gcugagggga gccuguacca gcagcgguuu aaguaugucu ucuaccucaa uggacgcgaa      660

aucaaccagc ugaaagagag auccuuugcc caacuuauua gcaaggacug gcccucuacg      720

gaaggcccua ucgaggagau uauguaucag ccguccagcc ugcuguucau cauugacucu      780

uuugaugaac ugaauuucgc guucgaggaa cccgaguuug cccuuugcga agacuggacc      840

caggagcacc cuguguccuu ccugaugagc ucucuccugc ggaaaguuau gcugcccgag      900

gcuucccucc uggugacaac ccgccuuaca accagcaaga gacugaaaca gcuccugaag      960

aaccaucacu acgucgaacu ucuggggaug uccgaggaug cccgggaaga guacaucuau     1020

caauuuuucg aggacaagcg cugggcuaug aaaguguuuu cuagccucaa guccaaugaa     1080

augcuguuca gcauguguca ggugccucug gucugcuggg ccgccuguac gugccucaaa     1140

cagcaaaugg agaagggagg cgauguuaca cugaccuguc agacaaccac cgcucuuuuu     1200

acaugcuaca uuucuucccu guucacgccc guggacggcg ggagcccguc ucucccuaac     1260

caggcgcagc ugagacggcu gugucaagug gccgcuaaag gaaucuggac caugacauau     1320

gucuuuuacc gcgaaaaucu uagacggcuc ggccugaccc agagcgaugu guccucuuuc     1380

auggacagca acaucauuca gaaggaugcc gaguaugaaa auugcuacgu uuuuacacac     1440

cuccaugugc aggaguucuu ugccgcuaug uucuauaugc ucaagggguc cugggaggcc     1500

ggaaacccca gcugucaacc uuucgaagac cugaaaucuc uucugcaguc caccagcuac     1560

aaggaucccc accucacgca gaugaaaugc uuucuguucg gccugcuuaa cgaggacaga     1620

gucaagcagc ucgaacgcac auuuaauugc aaaaugucuc ugaagaucaa guccaaacug     1680

cuccaaugua uggaggugcu ggggaacagc gacuacuccc ccucucagcu uggauuccug     1740

gaacucuuuc auugccugua ugagacccag gauaaggcgu ucauuagcca ggcuaugcgg     1800

uguuuuccua aaguugccau caauauuugc gagaagaucc accuucuugu guccucuuuc     1860

ugucucaaac acugcagaug ucugcgcacc auccggcuga gcgucacagu ggucuuugaa     1920

aagaaaauuc ucaagaccuc ccugccgaca aacacguggg acggcgauag aaucacccau     1980

ugcuggcaag accuuuguag cgugcugcac acaaaugagc aucuccgcga acuggaucug     2040

uaccacucua accuugacaa guccgccaug aauauucucc aucacgagcu gcggcacccc     2100

aacugcaaac ugcagaagcu ccugcuuaaa uucaucaccu uuccugaugg cugucaggac     2160

auuagcacau cucugaucca uaauaagaac cucaugcacc uggaucugaa aggguccgac     2220

aucggagaua auggcguuaa gagccuuugc gaagcucuga agcaucccga gugcaaacuc     2280

caaacccuga gacucgaguc uuguaaccug acgguguucu gcugucuuaa uauuagcaac     2340

gcccugaucc gcucccagag ccucauuuuu cugaaucugu cuaccaacaa ccuucuggac     2400

gauggggucc agcuccugug cgaagcucuc cggcacccua aguguuaucu ggagagacuu     2460

ucccuggaaa gcugcggacu cacagaggcc ggcugugagu accugucccu ggcgcuuauc     2520

ucuaauaaac gccugaccca ccucugccug gccgacaacg ugcucgggga cggcggaguu     2580

aagcugauga gcgaugcucu gcagcaugcc caauguacac ugaaaucccu ggugcuccgg     2640

agaugccacu ucaccucucu gagcuccgaa uaucuuucua cgagccugcu ccauaauaag     2700

ucccugacac accucgaccu gggcagcaac uggcuucagg auaauggggu caagcugcug     2760

ugugacgugu uccggcaucc cucuugcaac cuccaggauc uggagcuuau gggaugcgug     2820

cugaccaaug cuuguugccu cgaccuggcc uccguuauuc ucaacaaucc gaaccugcgc     2880

agccuugauc ugggcaauaa cgaccugcag gaugacgggg ucaaaauccu cugugaugcg     2940

cugagauacc cuaauugcaa cauucaacgg cuuggacugg aauauugugg ccucacaucu     3000

cugugcuguc aggaccucuc cagcgcccug aucugcaaua agagacuuau caaaaugaac     3060

cugacccaga acacccuggg guacgagggc auugugaagc ucuacaaagu gcugaagucu     3120

cccaagugua aacuucaggu ccugggacuc ugcaaggagg cuuuugauga agaggcccaa     3180

aaacugcugg aagcuguggg cguuuccaau ccucaccuca ucauuaagcc cgacuguaac     3240

uaucacaaug aggaagacgu gagcuggugg uggugcuucu ga                        3282


<210>  9144
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD1__Homo_sapiens__G3XAL1

<400>  9144

Met Glu Glu Gln Gly His Ser Glu Met Glu Ile Ile Pro Ser Glu Ser 
1               5                   10                  15      


His Pro His Ile Gln Leu Leu Lys Ser Asn Arg Glu Leu Leu Val Thr 
            20                  25                  30          


His Ile Arg Asn Thr Gln Cys Leu Val Asp Asn Leu Leu Lys Asn Asp 
        35                  40                  45              


Tyr Phe Ser Ala Glu Asp Ala Glu Ile Val Cys Ala Cys Pro Thr Gln 
    50                  55                  60                  


Pro Asp Lys Val Arg Lys Ile Leu Asp Leu Val Gln Ser Lys Gly Glu 
65                  70                  75                  80  


Glu Val Ser Glu Phe Phe Leu Tyr Leu Leu Gln Gln Leu Ala Asp Ala 
                85                  90                  95      


Tyr Val Asp Leu Arg Pro Trp Leu Leu Glu Ile Gly Phe Ser Pro Ser 
            100                 105                 110         


Leu Leu Thr Gln Ser Lys Val Val Val Asn Thr Asp Pro Val Ser Arg 
        115                 120                 125             


Tyr Thr Gln Gln Leu Arg His His Leu Gly Arg Asp Ser Lys Phe Val 
    130                 135                 140                 


Leu Cys Tyr Ala Gln Lys Glu Glu Leu Leu Leu Glu Glu Ile Tyr Met 
145                 150                 155                 160 


Asp Thr Ile Met Glu Leu Val Gly Phe Ser Asn Glu Ser Leu Gly Ser 
                165                 170                 175     


Leu Asn Ser Leu Ala Cys Leu Leu Asp His Thr Thr Gly Ile Leu Asn 
            180                 185                 190         


Glu Gln Gly Glu Thr Ile Phe Ile Leu Gly Asp Ala Gly Val Gly Lys 
        195                 200                 205             


Ser Met Leu Leu Gln Arg Leu Gln Ser Leu Trp Ala Thr Gly Arg Leu 
    210                 215                 220                 


Asp Ala Gly Val Lys Phe Phe Phe His Phe Arg Cys Arg Met Phe Ser 
225                 230                 235                 240 


Cys Phe Lys Glu Ser Asp Arg Leu Cys Leu Gln Asp Leu Leu Phe Lys 
                245                 250                 255     


His Tyr Cys Tyr Pro Glu Arg Asp Pro Glu Glu Val Phe Ala Phe Leu 
            260                 265                 270         


Leu Arg Phe Pro His Val Ala Leu Phe Thr Phe Asp Gly Leu Asp Glu 
        275                 280                 285             


Leu His Ser Asp Leu Asp Leu Ser Arg Val Pro Asp Ser Ser Cys Pro 
    290                 295                 300                 


Trp Glu Pro Ala His Pro Leu Val Leu Leu Ala Asn Leu Leu Ser Gly 
305                 310                 315                 320 


Lys Leu Leu Lys Gly Ala Ser Lys Leu Leu Thr Ala Arg Thr Gly Ile 
                325                 330                 335     


Glu Val Pro Arg Gln Phe Leu Arg Lys Lys Val Leu Leu Arg Gly Phe 
            340                 345                 350         


Ser Pro Ser His Leu Arg Ala Tyr Ala Arg Arg Met Phe Pro Glu Arg 
        355                 360                 365             


Ala Leu Gln Asp Arg Leu Leu Ser Gln Leu Glu Ala Asn Pro Asn Leu 
    370                 375                 380                 


Cys Ser Leu Cys Ser Val Pro Leu Phe Cys Trp Ile Ile Phe Arg Cys 
385                 390                 395                 400 


Phe Gln His Phe Arg Ala Ala Phe Glu Gly Ser Pro Gln Leu Pro Asp 
                405                 410                 415     


Cys Thr Met Thr Leu Thr Asp Val Phe Leu Leu Val Thr Glu Val His 
            420                 425                 430         


Leu Asn Arg Met Gln Pro Ser Ser Leu Val Gln Arg Asn Thr Arg Ser 
        435                 440                 445             


Pro Val Glu Thr Leu His Ala Gly Arg Asp Thr Leu Cys Ser Leu Gly 
    450                 455                 460                 


Gln Val Ala His Arg Gly Met Glu Lys Ser Leu Phe Val Phe Thr Gln 
465                 470                 475                 480 


Glu Glu Val Gln Ala Ser Gly Leu Gln Glu Arg Asp Met Gln Leu Gly 
                485                 490                 495     


Phe Leu Arg Ala Leu Pro Glu Leu Gly Pro Gly Gly Asp Gln Gln Ser 
            500                 505                 510         


Tyr Glu Phe Phe His Leu Thr Leu Gln Ala Phe Phe Thr Ala Phe Phe 
        515                 520                 525             


Leu Val Leu Asp Asp Arg Val Gly Thr Gln Glu Leu Leu Arg Phe Phe 
    530                 535                 540                 


Gln Glu Trp Met Pro Pro Ala Gly Ala Ala Thr Thr Ser Cys Tyr Pro 
545                 550                 555                 560 


Pro Phe Leu Pro Phe Gln Cys Leu Gln Gly Ser Gly Pro Ala Arg Glu 
                565                 570                 575     


Asp Leu Phe Lys Asn Lys Asp His Phe Gln Phe Thr Asn Leu Phe Leu 
            580                 585                 590         


Cys Gly Leu Leu Ser Lys Ala Lys Gln Lys Leu Leu Arg His Leu Val 
        595                 600                 605             


Pro Ala Ala Ala Leu Arg Arg Lys Arg Lys Ala Leu Trp Ala His Leu 
    610                 615                 620                 


Phe Ser Ser Leu Arg Gly Tyr Leu Lys Ser Leu Pro Arg Val Gln Val 
625                 630                 635                 640 


Glu Ser Phe Asn Gln Val Gln Ala Met Pro Thr Phe Ile Trp Met Leu 
                645                 650                 655     


Arg Cys Ile Tyr Glu Thr Gln Ser Gln Lys Val Gly Gln Leu Ala Ala 
            660                 665                 670         


Arg Gly Ile Cys Ala Asn Tyr Leu Lys Leu Thr Tyr Cys Asn Ala Cys 
        675                 680                 685             


Ser Ala Asp Cys Ser Ala Leu Ser Phe Val Leu His His Phe Pro Lys 
    690                 695                 700                 


Arg Leu Ala Leu Asp Leu Asp Asn Asn Asn Leu Asn Asp Tyr Gly Val 
705                 710                 715                 720 


Arg Glu Leu Gln Pro Cys Phe Ser Arg Leu Thr Val Leu Arg Leu Ser 
                725                 730                 735     


Val Asn Gln Ile Thr Asp Gly Gly Val Lys Val Leu Ser Glu Glu Leu 
            740                 745                 750         


Thr Lys Tyr Lys Ile Val Thr Tyr Leu Gly Leu Trp Lys Ser Val Asp 
        755                 760                 765             


Thr Ile Cys Phe Lys Lys Gln Gly Leu Leu Lys 
    770                 775                 


<210>  9145
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD1__Homo_sapiens__EAW93948

<400>  9145
auggaagagc agggccacag ugagauggaa auaaucccau cagagucuca cccccacauu       60

caauuacuga aaagcaaucg ggaacuucug gucacucaca uccgcaauac ucagugucug      120

guggacaacu ugcugaagaa ugacuacuuc ucggccgaag augcggagau ugugugugcc      180

ugccccaccc agccugacaa gguccgcaaa auucuggacc ugguacagag caagggcgag      240

gagguguccg aguucuuccu cuacuugcuc cagcaacucg cagaugccua cguggaccuc      300

aggccuuggc ugcuggagau cggcuucucc ccuucccugc ucacucagag caaagucgug      360

gucaacacug acccagugag cagguauacc cagcagcugc gacaccaucu gggccgugac      420

uccaaguucg ugcugugcua ugcccagaag gaggagcugc ugcuggagga gaucuacaug      480

gacaccauca uggagcuggu uggcuucagc aaugagagcc ugggcagccu gaacagccug      540

gccugccucc uggaccacac caccggcauc cucaaugagc agggugagac caucuucauc      600

cugggugaug cugggguggg caaguccaug cugcuacagc ggcugcagag ccucugggcc      660

acgggccggc uagacgcagg ggucaaauuc uucuuccacu uucgcugccg cauguucagc      720

ugcuucaagg aaagugacag gcugugucug caggaccugc ucuucaagca cuacugcuac      780

ccagagcggg accccgagga gguguuugcc uuccugcugc gcuuccccca cguggcccuc      840

uucaccuucg auggccugga cgagcugcac ucggacuugg accugagccg cgugccugac      900

agcuccugcc ccugggagcc ugcccacccc cuggucuugc uggccaaccu gcucaguggg      960

aagcugcuca agggggcuag caagcugcuc acagcccgca caggcaucga ggucccgcgc     1020

caguuccugc ggaagaaggu gcuucuccgg ggcuucuccc ccagccaccu gcgcgccuau     1080

gccaggagga uguuccccga gcgggcccug caggaccgcc ugcugagcca gcuggaggcc     1140

aaccccaacc ucugcagccu gugcucugug ccccucuucu gcuggaucau cuuccggugc     1200

uuccagcacu uccgugcugc cuuugaaggc ucaccacagc ugcccgacug cacgaugacc     1260

cugacagaug ucuuccuccu ggucacugag guccaucuga acaggaugca gcccagcagc     1320

cuggugcagc ggaacacacg cagcccagug gagacccucc acgccggccg ggacacucug     1380

ugcucgcugg ggcagguggc ccaccggggc auggagaaga gccucuuugu cuucacccag     1440

gaggaggugc aggccuccgg gcugcaggag agagacaugc agcugggcuu ccugcgggcu     1500

uugccggagc ugggccccgg gggugaccag caguccuaug aguuuuucca ccucacccuc     1560

caggccuucu uuacagccuu cuuccucgug cuggacgaca gggugggcac ucaggagcug     1620

cucagguucu uccaggagug gaugcccccu gcgggggcag cgaccacguc cugcuauccu     1680

cccuuccucc cguuccagug ccugcagggc agugguccgg cgcgggaaga ccucuucaag     1740

aacaaggauc acuuccaguu caccaaccuc uuccugugcg ggcuguuguc caaagccaaa     1800

cagaaacucc ugcggcaucu ggugcccgcg gcagcccuga ggagaaagcg caaggcccug     1860

ugggcacacc uguuuuccag ccugcggggc uaccugaaga gccugccccg cguucagguc     1920

gaaagcuuca accaggugca ggccaugccc acguucaucu ggaugcugcg cugcaucuac     1980

gagacacaga gccagaaggu ggggcagcug gcggccaggg gcaucugcgc caacuaccuc     2040

aagcugaccu acugcaacgc cugcucggcc gacugcagcg cccucuccuu cguccugcau     2100

cacuucccca agcggcuggc ccuagaccua gacaacaaca aucucaacga cuacggcgug     2160

cgggagcugc agcccugcuu cagccgccuc acuguucuca gacucagcgu aaaccagauc     2220

acugacggug ggguaaaggu gcuaagcgaa gagcugacca aauacaaaau ugugaccuau     2280

uugggacuuu ggaaaucagu agacaccaua ugcuucaaaa aacaggggcu auuaaaauga     2340


<210>  9146
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD1__Homo_sapiens__EAW93948

<400>  9146
auggaggagc agggccacag cgagauggag aucauccccu ccgagagcca cccgcacauc       60

cagcugcuca aguccaaccg cgagcugcug gugacccaca uccggaacac ccagugccuc      120

gucgacaacc ugcugaagaa cgacuacuuc agcgccgagg acgccgagau cgugugcgcg      180

ugccccacgc agcccgacaa ggugcgcaag auccucgacc ugguccaguc caagggggag      240

gaggugagcg aguucuuccu guaccuccug cagcagcugg ccgacgccua cguggaccuc      300

cggcccuggc ugcuggagau cggcuucucc ccgagccucc ugacccaguc caaggucgug      360

gugaacaccg accccgucag ccgcuacacc cagcagcugc ggcaccaccu cgggcgcgac      420

uccaaguucg ugcugugcua cgcccagaag gaggagcugc uccuggagga gaucuacaug      480

gacacgauca uggagcuggu gggcuucagc aacgaguccc ucgggagccu gaacucccug      540

gccugccucc uggaccacac caccggcauc cugaacgagc agggcgagac caucuucauc      600

cucggggacg cgggcgucgg caagagcaug cugcugcagc ggcuccaguc ccugugggcc      660

acggggcgcc uggacgccgg ggugaaguuc uucuuccacu uccggugccg cauguucagc      720

ugcuucaagg aguccgaccg gcucugccug caggaccugc uguucaagca cuacugcuac      780

cccgagcgcg accccgagga gguguucgcc uuccugcugc gguucccgca cgucgcgcug      840

uucaccuucg acggccugga cgagcugcac agcgaccucg accugagccg cgugcccgac      900

uccagcugcc ccugggagcc cgcccacccg cuggugcucc uggccaaccu gcuguccggc      960

aagcuccuga agggggccag caagcugcuc accgcccgga ccggcaucga ggucccccgc     1020

caguuccugc ggaagaaggu gcugcuccgc ggguucuccc ccagccaccu ccgggcguac     1080

gcccgccgga uguuccccga gcgcgcccug caggaccgcc uccuguccca gcuggaggcc     1140

aacccgaacc ucugcagccu gugcuccgug ccccuguucu gcuggaucau cuuccggugc     1200

uuccagcacu uccgcgccgc guucgagggc agcccccagc uccccgacug cacgaugacc     1260

cugaccgacg ucuuccugcu cgugaccgag gugcaccuga accggaugca gccguccagc     1320

cugguccagc gcaacacgcg gucccccgug gagacccucc acgccggccg cgacacccug     1380

ugcagccugg ggcaggucgc ccaccggggc auggagaagu cccucuucgu guucacccag     1440

gaggaggugc aggccagcgg gcugcaggag cgcgacaugc agcugggcuu ccuccgggcc     1500

cugcccgagc uggggcccgg cggcgaccag caguccuacg aguucuucca ccucacgcug     1560

caggcguucu ucaccgccuu cuuccugguc cucgacgacc gcguggggac ccaggagcug     1620

cugcgguucu uccaggagug gaugccgccc gccggcgccg ccaccacgag cugcuacccg     1680

cccuuccucc ccuuccagug ccugcagggg uccggccccg cgcgcgagga ccuguucaag     1740

aacaaggacc acuuccaguu caccaaccuc uuccugugcg ggcugcucag caaggccaag     1800

cagaagcugc ugcggcaccu cgugcccgcc gccgcgcugc gccggaagcg caaggcccug     1860

ugggcccacc ucuucagcuc ccugcggggc uaccucaaga gccucccgcg cguccaggug     1920

gaguccuuca accaggugca ggccaugccc accuucaucu ggaugcugcg gugcaucuac     1980

gagacccaga gccagaaggu cggccagcug gccgcgcgcg ggaucugcgc caacuaccuc     2040

aagcugacgu acugcaacgc cugcuccgcc gacugcagcg cccuguccuu cgugcuccac     2100

cacuucccca agcgccuggc gcuggaccuc gacaacaaca accugaacga cuacggcgug     2160

cgggagcugc agcccugcuu cagccgccuc accguccugc ggcuguccgu gaaccagauc     2220

accgacgggg gcgugaaggu ccucagcgag gagcugacca aguacaagau cgugacguac     2280

cuggggcucu ggaaguccgu ggacaccauc ugcuucaaga agcagggccu gcugaaguga     2340


<210>  9147
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD1__Homo_sapiens__EAW93948

<400>  9147
auggaggagc agggccacuc cgagauggag aucauccccu ccgaguccca cccccacauc       60

cagcuccuca aguccaaccg cgagcuccuc gucacccaca uccgcaacac ccagugccuc      120

gucgacaacc uccucaagaa cgacuacuuc uccgccgagg acgccgagau cgucugcgcc      180

ugccccaccc agcccgacaa gguccgcaag auccucgacc ucguccaguc caagggcgag      240

gaggucuccg aguucuuccu cuaccuccuc cagcagcucg ccgacgccua cgucgaccuc      300

cgccccuggc uccucgagau cggcuucucc cccucccucc ucacccaguc caaggucguc      360

gucaacaccg accccgucuc ccgcuacacc cagcagcucc gccaccaccu cggccgcgac      420

uccaaguucg uccucugcua cgcccagaag gaggagcucc uccucgagga gaucuacaug      480

gacaccauca uggagcucgu cggcuucucc aacgaguccc ucggcucccu caacucccuc      540

gccugccucc ucgaccacac caccggcauc cucaacgagc agggcgagac caucuucauc      600

cucggcgacg ccggcgucgg caaguccaug cuccuccagc gccuccaguc ccucugggcc      660

accggccgcc ucgacgccgg cgucaaguuc uucuuccacu uccgcugccg cauguucucc      720

ugcuucaagg aguccgaccg ccucugccuc caggaccucc ucuucaagca cuacugcuac      780

cccgagcgcg accccgagga ggucuucgcc uuccuccucc gcuuccccca cgucgcccuc      840

uucaccuucg acggccucga cgagcuccac uccgaccucg accucucccg cguccccgac      900

uccuccugcc ccugggagcc cgcccacccc cucguccucc ucgccaaccu ccucuccggc      960

aagcuccuca agggcgccuc caagcuccuc accgcccgca ccggcaucga ggucccccgc     1020

caguuccucc gcaagaaggu ccuccuccgc ggcuucuccc ccucccaccu ccgcgccuac     1080

gcccgccgca uguuccccga gcgcgcccuc caggaccgcc uccucuccca gcucgaggcc     1140

aaccccaacc ucugcucccu cugcuccguc ccccucuucu gcuggaucau cuuccgcugc     1200

uuccagcacu uccgcgccgc cuucgagggc uccccccagc uccccgacug caccaugacc     1260

cucaccgacg ucuuccuccu cgucaccgag guccaccuca accgcaugca gcccuccucc     1320

cucguccagc gcaacacccg cucccccguc gagacccucc acgccggccg cgacacccuc     1380

ugcucccucg gccaggucgc ccaccgcggc auggagaagu cccucuucgu cuucacccag     1440

gaggaggucc aggccuccgg ccuccaggag cgcgacaugc agcucggcuu ccuccgcgcc     1500

cuccccgagc ucggccccgg cggcgaccag caguccuacg aguucuucca ccucacccuc     1560

caggccuucu ucaccgccuu cuuccucguc cucgacgacc gcgucggcac ccaggagcuc     1620

cuccgcuucu uccaggagug gaugcccccc gccggcgccg ccaccaccuc cugcuacccc     1680

cccuuccucc ccuuccagug ccuccagggc uccggccccg cccgcgagga ccucuucaag     1740

aacaaggacc acuuccaguu caccaaccuc uuccucugcg gccuccucuc caaggccaag     1800

cagaagcucc uccgccaccu cguccccgcc gccgcccucc gccgcaagcg caaggcccuc     1860

ugggcccacc ucuucuccuc ccuccgcggc uaccucaagu cccucccccg cguccagguc     1920

gaguccuuca accaggucca ggccaugccc accuucaucu ggaugcuccg cugcaucuac     1980

gagacccagu cccagaaggu cggccagcuc gccgcccgcg gcaucugcgc caacuaccuc     2040

aagcucaccu acugcaacgc cugcuccgcc gacugcuccg cccucuccuu cguccuccac     2100

cacuucccca agcgccucgc ccucgaccuc gacaacaaca accucaacga cuacggcguc     2160

cgcgagcucc agcccugcuu cucccgccuc accguccucc gccucuccgu caaccagauc     2220

accgacggcg gcgucaaggu ccucuccgag gagcucacca aguacaagau cgucaccuac     2280

cucggccucu ggaaguccgu cgacaccauc ugcuucaaga agcagggccu ccucaaguga     2340


<210>  9148
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD1__Homo_sapiens__EAW93948

<400>  9148
auggaggaac agggccacag cgagauggaa aucauucccu ccgagucuca uccucacaua       60

caacugcuca agucaaacag agaacuucug gugacccaua ucaggaauac acagugcuug      120

gucgacaacu uacugaaaaa ugauuacuuc agugccgagg acgcugagau uguuugugca      180

ugcccaacuc agccggauaa ggugcggaaa auccuagacc ucguacagag caagggggaa      240

gagguguccg aauuuuuccu guaucuucug caacaguugg ccgaugcgua cgucgaccuc      300

cgccccuggc ugcuggagau uggauuuucu ccuucgcucu uaacgcaguc aaaagugguu      360

gugaacaccg auccagucag ccgauauaca cagcaacugc gucaccaucu ugguagagac      420

aguaaguucg uguuguguua cgcucagaag gaggaacugc uacucgagga aaucuauaug      480

gauacuauaa uggagcuggu aggcuuuucc aaugaaucuc uugggagccu gaacuccuug      540

gccugccucc uggaccacac cacaggaauc uuaaaugagc agggcgagac cauuuucauc      600

cugggugaug cagggguugg aaaaucaaug cuccuucaga ggcugcaaag uuugugggcc      660

acuggccggc uagacgcugg cgugaaguuu uucuuucacu uccgcuguag aauguuuagc      720

ugcuucaaag aaucugauag gcugugucuc caggaccugc uuuuuaagca uuacugcuau      780

cccgagcggg acccugaaga ggucuucgca uuccuguugc gcuuuccaca cguggcccuc      840

uucacauuug augggcugga cgaauuacau uccgaucugg accuaucacg agugcccgau      900

agcaguuguc cuugggagcc agcucacccg cucguccugc uugccaacuu gcugucugga      960

aaacuccuga agggugcguc caaacuucug accgcaagaa cgggcauuga gguucccagg     1020

caguucuugc ggaagaaggu gcuccugcgu ggguuuagcc cuucgcacuu acgcgccuac     1080

gcuagaagga uguucccaga acgggcccug caagaccgac uacucucuca gcuggaggca     1140

aaucccaacc uuugcuccuu guguucagua ccucuguuuu gcuggaucau auuccgcugc     1200

uuucagcauu ucagagcugc cuuugaagga aguccacagc uccccgauug uacuaugacc     1260

cugacagacg uguucuuacu ggucacugag gugcaccuua auaggaugca accgagcucc     1320

uugguucagc ggaacacccg cucuccugug gaaacacucc augcgggcag agauacccug     1380

ugcagccuag gucaggucgc ccacaggggg auggagaaau cacuguuugu guucacgcag     1440

gaggaaguac aagcaagugg acuccaggag cgugacaugc agcugggcuu ccuucgggcu     1500

uugcccgaac ugggcccagg gggagaucag caauccuacg aguuuuucca uuuaacucuc     1560

caggccuuuu ucacagccuu uuuccugguu cuugacgacc gaguggguac ccaggagcug     1620

uugagauuuu uccaggaaug gaugccuccc gcuggcgcag ccacuacaag cuguuaucca     1680

cccuuucucc cuuuccaaug ccugcagggg ucuggaccag cuagggagga ucuauuuaag     1740

aauaaagacc acuuccaguu uaccaaccug uuccucugug gccugcuuuc aaaggcgaaa     1800

caaaaguugc ugcgccacuu agucccggca gccgcucucc ggagaaagag gaaagcccug     1860

ugggcacauc uuuucaguag ccugcgcggu uaccuaaagu cccucccccg agugcagguc     1920

gaaucuuuua aucaggugca ggccaugccu acguucauuu ggaugcugcg gugcaucuau     1980

gagacccaau cgcagaaagu ugggcaguug gcugcccgug gcauuugugc aaacuaccug     2040

aaguuaacau auugcaacgc guguagcgcu gauugcuccg cccucucauu ugugcugcac     2100

cauuucccaa aaagacuugc acuggacuug gauaauaaca aucucaacga cuacggagua     2160

agggaacugc agcccuguuu uagucgccua acuguccugc ggcuuucugu gaaucaaauc     2220

accgauggcg ggguuaaggu gcucagcgag gagcugacaa aguauaaaau cgucacuuac     2280

uugggacugu ggaaguccgu ggacaccauu ugcuucaaaa agcaggguuu acucaaauga     2340


<210>  9149
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD1__Homo_sapiens__EAW93948

<400>  9149
auggaggagc agggccacag cgagauggag aucaucccca gcgagagcca cccccacauc       60

cagcugcuga agagcaacag agagcugcug gugacccaca ucagaaacac ccagugccug      120

guggacaacc ugcugaagaa cgacuacuuc agcgccgagg acgccgagau cgugugcgcc      180

ugccccaccc agcccgacaa ggugagaaag auccuggacc uggugcagag caagggcgag      240

gaggugagcg aguucuuccu guaccugcug cagcagcugg ccgacgccua cguggaccug      300

agacccuggc ugcuggagau cggcuucagc cccagccugc ugacccagag caagguggug      360

gugaacaccg accccgugag cagauacacc cagcagcuga gacaccaccu gggcagagac      420

agcaaguucg ugcugugcua cgcccagaag gaggagcugc ugcuggagga gaucuacaug      480

gacaccauca uggagcuggu gggcuucagc aacgagagcc ugggcagccu gaacagccug      540

gccugccugc uggaccacac caccggcauc cugaacgagc agggcgagac caucuucauc      600

cugggcgacg ccggcguggg caagagcaug cugcugcaga gacugcagag ccugugggcc      660

accggcagac uggacgccgg cgugaaguuc uucuuccacu ucagaugcag aauguucagc      720

ugcuucaagg agagcgacag acugugccug caggaccugc uguucaagca cuacugcuac      780

cccgagagag accccgagga gguguucgcc uuccugcuga gauuccccca cguggcccug      840

uucaccuucg acggccugga cgagcugcac agcgaccugg accugagcag agugcccgac      900

agcagcugcc ccugggagcc cgcccacccc cuggugcugc uggccaaccu gcugagcggc      960

aagcugcuga agggcgccag caagcugcug accgccagaa ccggcaucga ggugcccaga     1020

caguuccuga gaaagaaggu gcugcugaga ggcuucagcc ccagccaccu gagagccuac     1080

gccagaagaa uguuccccga gagagcccug caggacagac ugcugagcca gcuggaggcc     1140

aaccccaacc ugugcagccu gugcagcgug ccccuguucu gcuggaucau cuucagaugc     1200

uuccagcacu ucagagccgc cuucgagggc agcccccagc ugcccgacug caccaugacc     1260

cugaccgacg uguuccugcu ggugaccgag gugcaccuga acagaaugca gcccagcagc     1320

cuggugcaga gaaacaccag aagccccgug gagacccugc acgccggcag agacacccug     1380

ugcagccugg gccagguggc ccacagaggc auggagaaga gccuguucgu guucacccag     1440

gaggaggugc aggccagcgg ccugcaggag agagacaugc agcugggcuu ccugagagcc     1500

cugcccgagc ugggccccgg cggcgaccag cagagcuacg aguucuucca ccugacccug     1560

caggccuucu ucaccgccuu cuuccuggug cuggacgaca gagugggcac ccaggagcug     1620

cugagauucu uccaggagug gaugcccccc gccggcgccg ccaccaccag cugcuacccc     1680

cccuuccugc ccuuccagug ccugcagggc agcggccccg ccagagagga ccuguucaag     1740

aacaaggacc acuuccaguu caccaaccug uuccugugcg gccugcugag caaggccaag     1800

cagaagcugc ugagacaccu ggugcccgcc gccgcccuga gaagaaagag aaaggcccug     1860

ugggcccacc uguucagcag ccugagaggc uaccugaaga gccugcccag agugcaggug     1920

gagagcuuca accaggugca ggccaugccc accuucaucu ggaugcugag augcaucuac     1980

gagacccaga gccagaaggu gggccagcug gccgccagag gcaucugcgc caacuaccug     2040

aagcugaccu acugcaacgc cugcagcgcc gacugcagcg cccugagcuu cgugcugcac     2100

cacuucccca agagacuggc ccuggaccug gacaacaaca accugaacga cuacggcgug     2160

agagagcugc agcccugcuu cagcagacug accgugcuga gacugagcgu gaaccagauc     2220

accgacggcg gcgugaaggu gcugagcgag gagcugacca aguacaagau cgugaccuac     2280

cugggccugu ggaagagcgu ggacaccauc ugcuucaaga agcagggccu gcugaaguga     2340


<210>  9150
<211>  2340
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD1__Homo_sapiens__EAW93948

<400>  9150
auggaggaac agggccacag cgagauggaa aucauucccu ccgagucuca uccucacauc       60

caacugcuca agagcaacag agaacugcuu gugacccaua uucggaauac acagugccug      120

gucgacaacc uccugaaaaa ugauuacuuc uccgccgagg acgcugagau cguuugugcc      180

ugcccgacgc agcccgauaa ggugcgcaaa auucuugacc uggugcaguc uaagggggaa      240

gaggucagcg aauuuuuccu cuaucugcug caacagcucg cggaugcuua cguggaccug      300

agaccuuggc uucuggagau cggauuuucc cccucucucc ugacccagag caaaguugug      360

gucaacacag auccuguguc ccgguauacc cagcaacuuc gccaccaucu gggcagagac      420

agcaaguucg uucucuguua cgcccagaag gaggaacugc ugcucgagga aaucuauaug      480

gauacaauua uggagcuggu gggguuuucu aaugaauccc uuggaagccu gaacucucuc      540

gccugccugc uugaccacac cacaggcauc cugaaugagc agggggagac cauuuucauc      600

cucggagaug cuggcgucgg caaauccaug cugcugcagc ggcuccaaag ccugugggcc      660

acggggcgcc uugacgcugg agugaaguuu uucuuucacu ucagaugucg gauguuuucu      720

ugcuucaaag aauccgaucg ccugugucuc caggaccugc uuuuuaagca uuacugcuau      780

cccgagagag acccugaaga gguguucgcc uuccugcucc gguuuccgca cgucgcgcug      840

uucaccuuug auggccugga cgaacuccau agcgaucugg accuuucccg cguucccgau      900

ucuagcuguc cuugggagcc cgcccacccu cuggugcucc uggcuaaccu gcuuuccggg      960

aaacuccuga agggagccag caagcugcuc acagcuagaa ccggcauuga ggugccccgg     1020

caguuccugc gcaaaaaggu ccuucugaga ggguuuucuc cgucccaccu ccgggccuac     1080

gcgagacgca uguucccuga acgggcccug caagacagac ugcuuagcca gcucgaggcu     1140

aaucccaacc ugugcucucu guguagcgug ccucucuuuu gcuggaucau uuuccgcugc     1200

uuucagcauu uccgggccgc uuuugaagga ucuccccagc ugcccgauug uacaaugacc     1260

cuuacggacg uuuuccugcu cgugacagag guccaccuga auagaaugca accuuccagc     1320

cuggugcagc gcaacacccg guccccgguu gaaacacuuc augccggcag agauacccuc     1380

ugcagccugg gccagguggc ccaccgcggg auggagaaau cucuguuugu cuucacccag     1440

gaggaagugc aggcuuccgg acuccaagag cgggacaugc agcugggcuu ccuuagagcg     1500

cugcccgaac ucgggccugg aggcgaucag caaagcuacg aguuuuucca ucugacacug     1560

caggccuuuu ucacggccuu uuuccuuguc cucgacgacc gcguggggac ccaggagcug     1620

cugcgguuuu uccaggaaug gaugcccccu gcuggagccg cuacaaccuc uuguuauccc     1680

ccguuucucc cuuuccaaug ccugcagggc uccggccccg ccagagagga ucuuuuuaag     1740

aauaaagacc acuuccaguu uacaaaccug uuccucugug ggcugcugag caaggcgaaa     1800

caaaagcugc ugcggcaccu cguuccugcu gccgcccugc gcagaaagcg gaaagcucuc     1860

ugggcccauc uguucuccuc ucuuagagga uaccuuaaga gccucccccg cgugcagguc     1920

gaauccuuua aucaggugca ggcuaugccu accuucaucu ggaugcugcg gugcaucuau     1980

gagacgcaau cucagaaagu uggccagcug gccgcgagag ggauuugugc caacuaccuu     2040

aagcugacau auugcaacgc uuguagcgcc gauugcuccg cucucagcuu ugugcugcac     2100

cauuucccca aacgccucgc ccuggaccuu gauaauaaca aucugaacga cuacggaguc     2160

agagaacucc agccguguuu uucucggcug accgugcugc gccuuuccgu gaaucaaauc     2220

accgauggcg ggguuaaggu ccugagcgag gagcucacaa aguauaaaau ugugaccuac     2280

cugggccucu ggaagucugu ggacacaauc ugcuucaaaa agcagggacu gcuuaaauga     2340


<210>  9151
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD1__Homo_sapiens__Q9Y239

<400>  9151

Met Glu Glu Gln Gly His Ser Glu Met Glu Ile Ile Pro Ser Glu Ser 
1               5                   10                  15      


His Pro His Ile Gln Leu Leu Lys Ser Asn Arg Glu Leu Leu Val Thr 
            20                  25                  30          


His Ile Arg Asn Thr Gln Cys Leu Val Asp Asn Leu Leu Lys Asn Asp 
        35                  40                  45              


Tyr Phe Ser Ala Glu Asp Ala Glu Ile Val Cys Ala Cys Pro Thr Gln 
    50                  55                  60                  


Pro Asp Lys Val Arg Lys Ile Leu Asp Leu Val Gln Ser Lys Gly Glu 
65                  70                  75                  80  


Glu Val Ser Glu Phe Phe Leu Tyr Leu Leu Gln Gln Leu Ala Asp Ala 
                85                  90                  95      


Tyr Val Asp Leu Arg Pro Trp Leu Leu Glu Ile Gly Phe Ser Pro Ser 
            100                 105                 110         


Leu Leu Thr Gln Ser Lys Val Val Val Asn Thr Asp Pro Val Ser Arg 
        115                 120                 125             


Tyr Thr Gln Gln Leu Arg His His Leu Gly Arg Asp Ser Lys Phe Val 
    130                 135                 140                 


Leu Cys Tyr Ala Gln Lys Glu Glu Leu Leu Leu Glu Glu Ile Tyr Met 
145                 150                 155                 160 


Asp Thr Ile Met Glu Leu Val Gly Phe Ser Asn Glu Ser Leu Gly Ser 
                165                 170                 175     


Leu Asn Ser Leu Ala Cys Leu Leu Asp His Thr Thr Gly Ile Leu Asn 
            180                 185                 190         


Glu Gln Gly Glu Thr Ile Phe Ile Leu Gly Asp Ala Gly Val Gly Lys 
        195                 200                 205             


Ser Met Leu Leu Gln Arg Leu Gln Ser Leu Trp Ala Thr Gly Arg Leu 
    210                 215                 220                 


Asp Ala Gly Val Lys Phe Phe Phe His Phe Arg Cys Arg Met Phe Ser 
225                 230                 235                 240 


Cys Phe Lys Glu Ser Asp Arg Leu Cys Leu Gln Asp Leu Leu Phe Lys 
                245                 250                 255     


His Tyr Cys Tyr Pro Glu Arg Asp Pro Glu Glu Val Phe Ala Phe Leu 
            260                 265                 270         


Leu Arg Phe Pro His Val Ala Leu Phe Thr Phe Asp Gly Leu Asp Glu 
        275                 280                 285             


Leu His Ser Asp Leu Asp Leu Ser Arg Val Pro Asp Ser Ser Cys Pro 
    290                 295                 300                 


Trp Glu Pro Ala His Pro Leu Val Leu Leu Ala Asn Leu Leu Ser Gly 
305                 310                 315                 320 


Lys Leu Leu Lys Gly Ala Ser Lys Leu Leu Thr Ala Arg Thr Gly Ile 
                325                 330                 335     


Glu Val Pro Arg Gln Phe Leu Arg Lys Lys Val Leu Leu Arg Gly Phe 
            340                 345                 350         


Ser Pro Ser His Leu Arg Ala Tyr Ala Arg Arg Met Phe Pro Glu Arg 
        355                 360                 365             


Ala Leu Gln Asp Arg Leu Leu Ser Gln Leu Glu Ala Asn Pro Asn Leu 
    370                 375                 380                 


Cys Ser Leu Cys Ser Val Pro Leu Phe Cys Trp Ile Ile Phe Arg Cys 
385                 390                 395                 400 


Phe Gln His Phe Arg Ala Ala Phe Glu Gly Ser Pro Gln Leu Pro Asp 
                405                 410                 415     


Cys Thr Met Thr Leu Thr Asp Val Phe Leu Leu Val Thr Glu Val His 
            420                 425                 430         


Leu Asn Arg Met Gln Pro Ser Ser Leu Val Gln Arg Asn Thr Arg Ser 
        435                 440                 445             


Pro Val Glu Thr Leu His Ala Gly Arg Asp Thr Leu Cys Ser Leu Gly 
    450                 455                 460                 


Gln Val Ala His Arg Gly Met Glu Lys Ser Leu Phe Val Phe Thr Gln 
465                 470                 475                 480 


Glu Glu Val Gln Ala Ser Gly Leu Gln Glu Arg Asp Met Gln Leu Gly 
                485                 490                 495     


Phe Leu Arg Ala Leu Pro Glu Leu Gly Pro Gly Gly Asp Gln Gln Ser 
            500                 505                 510         


Tyr Glu Phe Phe His Leu Thr Leu Gln Ala Phe Phe Thr Ala Phe Phe 
        515                 520                 525             


Leu Val Leu Asp Asp Arg Val Gly Thr Gln Glu Leu Leu Arg Phe Phe 
    530                 535                 540                 


Gln Glu Trp Met Pro Pro Ala Gly Ala Ala Thr Thr Ser Cys Tyr Pro 
545                 550                 555                 560 


Pro Phe Leu Pro Phe Gln Cys Leu Gln Gly Ser Gly Pro Ala Arg Glu 
                565                 570                 575     


Asp Leu Phe Lys Asn Lys Asp His Phe Gln Phe Thr Asn Leu Phe Leu 
            580                 585                 590         


Cys Gly Leu Leu Ser Lys Ala Lys Gln Lys Leu Leu Arg His Leu Val 
        595                 600                 605             


Pro Ala Ala Ala Leu Arg Arg Lys Arg Lys Ala Leu Trp Ala His Leu 
    610                 615                 620                 


Phe Ser Ser Leu Arg Gly Tyr Leu Lys Ser Leu Pro Arg Val Gln Val 
625                 630                 635                 640 


Glu Ser Phe Asn Gln Val Gln Ala Met Pro Thr Phe Ile Trp Met Leu 
                645                 650                 655     


Arg Cys Ile Tyr Glu Thr Gln Ser Gln Lys Val Gly Gln Leu Ala Ala 
            660                 665                 670         


Arg Gly Ile Cys Ala Asn Tyr Leu Lys Leu Thr Tyr Cys Asn Ala Cys 
        675                 680                 685             


Ser Ala Asp Cys Ser Ala Leu Ser Phe Val Leu His His Phe Pro Lys 
    690                 695                 700                 


Arg Leu Ala Leu Asp Leu Asp Asn Asn Asn Leu Asn Asp Tyr Gly Val 
705                 710                 715                 720 


Arg Glu Leu Gln Pro Cys Phe Ser Arg Leu Thr Val Leu Arg Leu Ser 
                725                 730                 735     


Val Asn Gln Ile Thr Asp Gly Gly Val Lys Val Leu Ser Glu Glu Leu 
            740                 745                 750         


Thr Lys Tyr Lys Ile Val Thr Tyr Leu Gly Leu Tyr Asn Asn Gln Ile 
        755                 760                 765             


Thr Asp Val Gly Ala Arg Tyr Val Thr Lys Ile Leu Asp Glu Cys Lys 
    770                 775                 780                 


Gly Leu Thr His Leu Lys Leu Gly Lys Asn Lys Ile Thr Ser Glu Gly 
785                 790                 795                 800 


Gly Lys Tyr Leu Ala Leu Ala Val Lys Asn Ser Lys Ser Ile Ser Glu 
                805                 810                 815     


Val Gly Met Trp Gly Asn Gln Val Gly Asp Glu Gly Ala Lys Ala Phe 
            820                 825                 830         


Ala Glu Ala Leu Arg Asn His Pro Ser Leu Thr Thr Leu Ser Leu Ala 
        835                 840                 845             


Ser Asn Gly Ile Ser Thr Glu Gly Gly Lys Ser Leu Ala Arg Ala Leu 
    850                 855                 860                 


Gln Gln Asn Thr Ser Leu Glu Ile Leu Trp Leu Thr Gln Asn Glu Leu 
865                 870                 875                 880 


Asn Asp Glu Val Ala Glu Ser Leu Ala Glu Met Leu Lys Val Asn Gln 
                885                 890                 895     


Thr Leu Lys His Leu Trp Leu Ile Gln Asn Gln Ile Thr Ala Lys Gly 
            900                 905                 910         


Thr Ala Gln Leu Ala Asp Ala Leu Gln Ser Asn Thr Gly Ile Thr Glu 
        915                 920                 925             


Ile Cys Leu Asn Gly Asn Leu Ile Lys Pro Glu Glu Ala Lys Val Tyr 
    930                 935                 940                 


Glu Asp Glu Lys Arg Ile Ile Cys Phe 
945                 950             


<210>  9152
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD1__Homo_sapiens__AAD28350

<400>  9152
auggaagagc agggccacag ugagauggaa auaaucccau cagagucuca cccccacauu       60

caauuacuga aaagcaaucg ggaacuucug gucacucaca uccgcaauac ucagugucug      120

guggacaacu ugcugaagaa ugacuacuuc ucggccgaag augcggagau ugugugugcc      180

ugccccaccc agccugacaa gguccgcaaa auucuggacc ugguacagag caagggcgag      240

gagguguccg aguucuuccu cuacuugcuc cagcaacucg cagaugccua cguggaccuc      300

aggccuuggc ugcuggagau cggcuucucc ccuucccugc ucacucagag caaagucgug      360

gucaacacug acccagugag cagguauacc cagcagcugc gacaccaucu gggccgugac      420

uccaaguucg ugcugugcua ugcccagaag gaggagcugc ugcuggagga gaucuacaug      480

gacaccauca uggagcuggu uggcuucagc aaugagagcc ugggcagccu gaacagccug      540

gccugccucc uggaccacac caccggcauc cucaaugagc agggugagac caucuucauc      600

cugggugaug cugggguggg caaguccaug cugcuacagc ggcugcagag ccucugggcc      660

acgggccggc uagacgcagg ggucaaauuc uucuuccacu uucgcugccg cauguucagc      720

ugcuucaagg aaagugacag gcugugucug caggaccugc ucuucaagca cuacugcuac      780

ccagagcggg accccgagga gguguuugcc uuccugcugc gcuuccccca cguggcccuc      840

uucaccuucg auggccugga cgagcugcac ucggacuugg accugagccg cgugccugac      900

agcuccugcc ccugggagcc ugcccacccc cuggucuugc uggccaaccu gcucaguggg      960

aagcugcuca agggggcuag caagcugcuc acagcccgca caggcaucga ggucccgcgc     1020

caguuccugc ggaagaaggu gcuucuccgg ggcuucuccc ccagccaccu gcgcgccuau     1080

gccaggagga uguuccccga gcgggcccug caggaccgcc ugcugagcca gcuggaggcc     1140

aaccccaacc ucugcagccu gugcucugug ccccucuucu gcuggaucau cuuccggugc     1200

uuccagcacu uccgugcugc cuuugaaggc ucaccacagc ugcccgacug cacgaugacc     1260

cugacagaug ucuuccuccu ggucacugag guccaucuga acaggaugca gcccagcagc     1320

cuggugcagc ggaacacacg cagcccagug gagacccucc acgccggccg ggacacucug     1380

ugcucgcugg ggcagguggc ccaccggggc auggagaaga gccucuuugu cuucacccag     1440

gaggaggugc aggccuccgg gcugcaggag agagacaugc agcugggcuu ccugcgggcu     1500

uugccggagc ugggccccgg gggugaccag caguccuaug aguuuuucca ccucacccuc     1560

caggccuucu uuacagccuu cuuccucgug cuggacgaca gggugggcac ucaggagcug     1620

cucagguucu uccaggagug gaugcccccu gcgggggcag cgaccacguc cugcuauccu     1680

cccuuccucc cguuccagug ccugcagggc agugguccgg cgcgggaaga ccucuucaag     1740

aacaaggauc acuuccaguu caccaaccuc uuccugugcg ggcuguuguc caaagccaaa     1800

cagaaacucc ugcggcaucu ggugcccgcg gcagcccuga ggagaaagcg caaggcccug     1860

ugggcacacc uguuuuccag ccugcggggc uaccugaaga gccugccccg cguucagguc     1920

gaaagcuuca accaggugca ggccaugccc acguucaucu ggaugcugcg cugcaucuac     1980

gagacacaga gccagaaggu ggggcagcug gcggccaggg gcaucugcgc caacuaccuc     2040

aagcugaccu acugcaacgc cugcucggcc gacugcagcg cccucuccuu cguccugcau     2100

cacuucccca agcggcuggc ccuagaccua gacaacaaca aucucaacga cuacggcgug     2160

cgggagcugc agcccugcuu cagccgccuc acuguucuca gacucagcgu aaaccagauc     2220

acugacggug ggguaaaggu gcuaagcgaa gagcugacca aauacaaaau ugugaccuau     2280

uuggguuuau acaacaacca gaucaccgau gucggagcca gguacgucac caaaauccug     2340

gaugaaugca aaggccucac gcaucuuaaa cugggaaaaa acaaaauaac aagugaagga     2400

gggaaguauc ucgcccuggc ugugaagaac agcaaaucaa ucucugaggu ugggaugugg     2460

ggcaaucaag uuggggauga aggagcaaaa gccuucgcag aggcucugcg gaaccacccc     2520

agcuugacca cccugagucu ugcguccaac ggcaucucca cagaaggagg aaagagccuu     2580

gcgagggccc ugcagcagaa cacgucucua gaaauacugu ggcugaccca aaaugaacuc     2640

aacgaugaag uggcagagag uuuggcagaa auguugaaag ucaaccagac guuaaagcau     2700

uuauggcuua uccagaauca gaucacagcu aaggggacug cccagcuggc agaugcguua     2760

cagagcaaca cuggcauaac agagauuugc cuaaauggaa accugauaaa accagaggag     2820

gccaaagucu augaagauga gaagcggauu aucuguuucu ga                        2862


<210>  9153
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD1__Homo_sapiens__AAD28350

<400>  9153
auggaggagc agggccacag cgagauggag aucauccccu ccgagagcca cccgcacauc       60

cagcugcuca aguccaaccg cgagcugcug gugacccaca uccggaacac ccagugccuc      120

gucgacaacc ugcugaagaa cgacuacuuc agcgccgagg acgccgagau cgugugcgcg      180

ugccccacgc agcccgacaa ggugcgcaag auccucgacc ugguccaguc caagggggag      240

gaggugagcg aguucuuccu guaccuccug cagcagcugg ccgacgccua cguggaccuc      300

cggcccuggc ugcuggagau cggcuucucc ccgagccucc ugacccaguc caaggucgug      360

gugaacaccg accccgucag ccgcuacacc cagcagcugc ggcaccaccu cgggcgcgac      420

uccaaguucg ugcugugcua cgcccagaag gaggagcugc uccuggagga gaucuacaug      480

gacacgauca uggagcuggu gggcuucagc aacgaguccc ucgggagccu gaacucccug      540

gccugccucc uggaccacac caccggcauc cugaacgagc agggcgagac caucuucauc      600

cucggggacg cgggcgucgg caagagcaug cugcugcagc ggcuccaguc ccugugggcc      660

acggggcgcc uggacgccgg ggugaaguuc uucuuccacu uccggugccg cauguucagc      720

ugcuucaagg aguccgaccg gcucugccug caggaccugc uguucaagca cuacugcuac      780

cccgagcgcg accccgagga gguguucgcc uuccugcugc gguucccgca cgucgcgcug      840

uucaccuucg acggccugga cgagcugcac agcgaccucg accugagccg cgugcccgac      900

uccagcugcc ccugggagcc cgcccacccg cuggugcucc uggccaaccu gcuguccggc      960

aagcuccuga agggggccag caagcugcuc accgcccgga ccggcaucga ggucccccgc     1020

caguuccugc ggaagaaggu gcugcuccgc ggguucuccc ccagccaccu ccgggcguac     1080

gcccgccgga uguuccccga gcgcgcccug caggaccgcc uccuguccca gcuggaggcc     1140

aacccgaacc ucugcagccu gugcuccgug ccccuguucu gcuggaucau cuuccggugc     1200

uuccagcacu uccgcgccgc guucgagggc agcccccagc uccccgacug cacgaugacc     1260

cugaccgacg ucuuccugcu cgugaccgag gugcaccuga accggaugca gccguccagc     1320

cugguccagc gcaacacgcg gucccccgug gagacccucc acgccggccg cgacacccug     1380

ugcagccugg ggcaggucgc ccaccggggc auggagaagu cccucuucgu guucacccag     1440

gaggaggugc aggccagcgg gcugcaggag cgcgacaugc agcugggcuu ccuccgggcc     1500

cugcccgagc uggggcccgg cggcgaccag caguccuacg aguucuucca ccucacgcug     1560

caggcguucu ucaccgccuu cuuccugguc cucgacgacc gcguggggac ccaggagcug     1620

cugcgguucu uccaggagug gaugccgccc gccggcgccg ccaccacgag cugcuacccg     1680

cccuuccucc ccuuccagug ccugcagggg uccggccccg cgcgcgagga ccuguucaag     1740

aacaaggacc acuuccaguu caccaaccuc uuccugugcg ggcugcucag caaggccaag     1800

cagaagcugc ugcggcaccu cgugcccgcc gccgcgcugc gccggaagcg caaggcccug     1860

ugggcccacc ucuucagcuc ccugcggggc uaccucaaga gccucccgcg cguccaggug     1920

gaguccuuca accaggugca ggccaugccc accuucaucu ggaugcugcg gugcaucuac     1980

gagacccaga gccagaaggu cggccagcug gccgcgcgcg ggaucugcgc caacuaccuc     2040

aagcugacgu acugcaacgc cugcuccgcc gacugcagcg cccuguccuu cgugcuccac     2100

cacuucccca agcgccuggc gcuggaccuc gacaacaaca accugaacga cuacggcgug     2160

cgggagcugc agcccugcuu cagccgccuc accguccugc ggcuguccgu gaaccagauc     2220

accgacgggg gcgugaaggu ccucagcgag gagcugacca aguacaagau cgugacguac     2280

cuggggcucu acaacaacca gaucaccgac gugggcgccc gcuacgucac caagauccug     2340

gacgagugca agggccugac ccaccucaag cuggggaaga acaagaucac guccgagggc     2400

gggaaguacc uggcccucgc cgugaagaac agcaagucca ucagcgaggu gggcaugugg     2460

ggcaaccagg ucggggacga gggcgccaag gcguucgccg aggcccugcg gaaccacccg     2520

ucccugacca cccucagccu ggccuccaac gggaucagca ccgagggcgg caagagccug     2580

gcgcgcgccc uccagcagaa caccucccug gagauccugu ggcucacgca gaacgagcug     2640

aacgacgagg uggccgagag ccuggccgag augcucaagg ugaaccagac ccugaagcac     2700

cuguggcuca uccagaacca gaucaccgcc aaggggaccg cgcagcuggc cgacgcccug     2760

caguccaaca cgggcaucac cgagaucugc cucaacggga accugaucaa gcccgaggag     2820

gccaaggucu acgaggacga gaagcggauc aucugcuucu ga                        2862


<210>  9154
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD1__Homo_sapiens__AAD28350

<400>  9154
auggaggagc agggccacuc cgagauggag aucauccccu ccgaguccca cccccacauc       60

cagcuccuca aguccaaccg cgagcuccuc gucacccaca uccgcaacac ccagugccuc      120

gucgacaacc uccucaagaa cgacuacuuc uccgccgagg acgccgagau cgucugcgcc      180

ugccccaccc agcccgacaa gguccgcaag auccucgacc ucguccaguc caagggcgag      240

gaggucuccg aguucuuccu cuaccuccuc cagcagcucg ccgacgccua cgucgaccuc      300

cgccccuggc uccucgagau cggcuucucc cccucccucc ucacccaguc caaggucguc      360

gucaacaccg accccgucuc ccgcuacacc cagcagcucc gccaccaccu cggccgcgac      420

uccaaguucg uccucugcua cgcccagaag gaggagcucc uccucgagga gaucuacaug      480

gacaccauca uggagcucgu cggcuucucc aacgaguccc ucggcucccu caacucccuc      540

gccugccucc ucgaccacac caccggcauc cucaacgagc agggcgagac caucuucauc      600

cucggcgacg ccggcgucgg caaguccaug cuccuccagc gccuccaguc ccucugggcc      660

accggccgcc ucgacgccgg cgucaaguuc uucuuccacu uccgcugccg cauguucucc      720

ugcuucaagg aguccgaccg ccucugccuc caggaccucc ucuucaagca cuacugcuac      780

cccgagcgcg accccgagga ggucuucgcc uuccuccucc gcuuccccca cgucgcccuc      840

uucaccuucg acggccucga cgagcuccac uccgaccucg accucucccg cguccccgac      900

uccuccugcc ccugggagcc cgcccacccc cucguccucc ucgccaaccu ccucuccggc      960

aagcuccuca agggcgccuc caagcuccuc accgcccgca ccggcaucga ggucccccgc     1020

caguuccucc gcaagaaggu ccuccuccgc ggcuucuccc ccucccaccu ccgcgccuac     1080

gcccgccgca uguuccccga gcgcgcccuc caggaccgcc uccucuccca gcucgaggcc     1140

aaccccaacc ucugcucccu cugcuccguc ccccucuucu gcuggaucau cuuccgcugc     1200

uuccagcacu uccgcgccgc cuucgagggc uccccccagc uccccgacug caccaugacc     1260

cucaccgacg ucuuccuccu cgucaccgag guccaccuca accgcaugca gcccuccucc     1320

cucguccagc gcaacacccg cucccccguc gagacccucc acgccggccg cgacacccuc     1380

ugcucccucg gccaggucgc ccaccgcggc auggagaagu cccucuucgu cuucacccag     1440

gaggaggucc aggccuccgg ccuccaggag cgcgacaugc agcucggcuu ccuccgcgcc     1500

cuccccgagc ucggccccgg cggcgaccag caguccuacg aguucuucca ccucacccuc     1560

caggccuucu ucaccgccuu cuuccucguc cucgacgacc gcgucggcac ccaggagcuc     1620

cuccgcuucu uccaggagug gaugcccccc gccggcgccg ccaccaccuc cugcuacccc     1680

cccuuccucc ccuuccagug ccuccagggc uccggccccg cccgcgagga ccucuucaag     1740

aacaaggacc acuuccaguu caccaaccuc uuccucugcg gccuccucuc caaggccaag     1800

cagaagcucc uccgccaccu cguccccgcc gccgcccucc gccgcaagcg caaggcccuc     1860

ugggcccacc ucuucuccuc ccuccgcggc uaccucaagu cccucccccg cguccagguc     1920

gaguccuuca accaggucca ggccaugccc accuucaucu ggaugcuccg cugcaucuac     1980

gagacccagu cccagaaggu cggccagcuc gccgcccgcg gcaucugcgc caacuaccuc     2040

aagcucaccu acugcaacgc cugcuccgcc gacugcuccg cccucuccuu cguccuccac     2100

cacuucccca agcgccucgc ccucgaccuc gacaacaaca accucaacga cuacggcguc     2160

cgcgagcucc agcccugcuu cucccgccuc accguccucc gccucuccgu caaccagauc     2220

accgacggcg gcgucaaggu ccucuccgag gagcucacca aguacaagau cgucaccuac     2280

cucggccucu acaacaacca gaucaccgac gucggcgccc gcuacgucac caagauccuc     2340

gacgagugca agggccucac ccaccucaag cucggcaaga acaagaucac cuccgagggc     2400

ggcaaguacc ucgcccucgc cgucaagaac uccaagucca ucuccgaggu cggcaugugg     2460

ggcaaccagg ucggcgacga gggcgccaag gccuucgccg aggcccuccg caaccacccc     2520

ucccucacca cccucucccu cgccuccaac ggcaucucca ccgagggcgg caagucccuc     2580

gcccgcgccc uccagcagaa caccucccuc gagauccucu ggcucaccca gaacgagcuc     2640

aacgacgagg ucgccgaguc ccucgccgag augcucaagg ucaaccagac ccucaagcac     2700

cucuggcuca uccagaacca gaucaccgcc aagggcaccg cccagcucgc cgacgcccuc     2760

caguccaaca ccggcaucac cgagaucugc cucaacggca accucaucaa gcccgaggag     2820

gccaaggucu acgaggacga gaagcgcauc aucugcuucu ga                        2862


<210>  9155
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD1__Homo_sapiens__AAD28350

<400>  9155
auggaggaac agggccacag cgagauggaa aucauucccu ccgagucuca uccucacaua       60

caacugcuca agucaaacag agaacuucug gugacccaua ucaggaauac acagugcuug      120

gucgacaacu uacugaaaaa ugauuacuuc agugccgagg acgcugagau uguuugugca      180

ugcccaacuc agccggauaa ggugcggaaa auccuagacc ucguacagag caagggggaa      240

gagguguccg aauuuuuccu guaucuucug caacaguugg ccgaugcgua cgucgaccuc      300

cgccccuggc ugcuggagau uggauuuucu ccuucgcucu uaacgcaguc aaaagugguu      360

gugaacaccg auccagucag ccgauauaca cagcaacugc gucaccaucu ugguagagac      420

aguaaguucg uguuguguua cgcucagaag gaggaacugc uacucgagga aaucuauaug      480

gauacuauaa uggagcuggu aggcuuuucc aaugaaucuc uugggagccu gaacuccuug      540

gccugccucc uggaccacac cacaggaauc uuaaaugagc agggcgagac cauuuucauc      600

cugggugaug cagggguugg aaaaucaaug cuccuucaga ggcugcaaag uuugugggcc      660

acuggccggc uagacgcugg cgugaaguuu uucuuucacu uccgcuguag aauguuuagc      720

ugcuucaaag aaucugauag gcugugucuc caggaccugc uuuuuaagca uuacugcuau      780

cccgagcggg acccugaaga ggucuucgca uuccuguugc gcuuuccaca cguggcccuc      840

uucacauuug augggcugga cgaauuacau uccgaucugg accuaucacg agugcccgau      900

agcaguuguc cuugggagcc agcucacccg cucguccugc uugccaacuu gcugucugga      960

aaacuccuga agggugcguc caaacuucug accgcaagaa cgggcauuga gguucccagg     1020

caguucuugc ggaaaaaggu gcuccugcgu ggguuuagcc cuucgcacuu acgcgccuac     1080

gcuagaagga uguucccaga acgggcccug caagaccgac uacucucuca gcuggaggca     1140

aaucccaacc uuugcuccuu guguucagua ccucuguuuu gcuggaucau auuccgcugc     1200

uuucagcauu ucagagcugc cuuugaagga aguccacagc uccccgauug uacuaugacc     1260

cugacagacg uguucuuacu ggucacugag gugcaccuua auaggaugca accgagcucc     1320

uugguucagc ggaacacccg cucuccugug gaaacacucc augcgggcag agauacccug     1380

ugcagccuag gucaggucgc ccacaggggg auggagaaau cacuguuugu guucacgcag     1440

gaggaaguac aagcaagugg acuccaggag cgugacaugc agcugggcuu ccuucgggcu     1500

uugcccgaac ugggcccagg gggagaucag caauccuacg aguuuuucca uuuaacucuc     1560

caggccuuuu ucacagccuu uuuccugguu cuugacgacc gaguggguac ccaggagcug     1620

uugagauuuu uccaggaaug gaugccuccc gcuggcgcag ccacuacaag cuguuaucca     1680

cccuuucucc cuuuccaaug ccugcagggg ucuggaccag cuagggagga ucuauuuaag     1740

aauaaagacc acuuccaguu uaccaaccug uuccucugug gccugcuuuc aaaggcgaaa     1800

caaaaguugc ugcgccacuu agucccggca gccgcucucc ggagaaagag gaaagcccug     1860

ugggcacauc uuuucaguag ccugcgcggu uaccuaaagu cccucccccg agugcagguc     1920

gaaucuuuua aucaggugca ggccaugccu acguucauuu ggaugcugcg gugcaucuau     1980

gagacccaau cgcagaaagu ugggcaguug gcugcccgug gcauuugugc aaacuaccug     2040

aaguuaacau auugcaacgc guguagcgcu gauugcuccg cccucucauu ugugcugcac     2100

cauuucccaa aaagacuugc acuggacuug gauaauaaca aucucaacga cuacggagua     2160

agggaacugc agcccuguuu uagucgccua acuguccugc ggcuuucugu gaaucaaauc     2220

accgauggcg ggguuaaggu gcucagcgag gagcugacaa aguauaaaau cgucacuuac     2280

uugggacugu acaacaauca gauuaccgac gugggugcca gauauguaac aaagauauua     2340

gaugaaugca aaggccucac ccaccugaaa cuugggaaga acaagaucac uuccgaggga     2400

ggcaaguacc uggcuuuggc cgugaaaaau ucaaagagca uuucugaagu ugguaugugg     2460

gggaaccagg ucggcgacga gggagcaaag gcuuucgccg aagcgcucag gaaucacccu     2520

ucccugacga cacuaagucu ggccagcaac ggcaucucua ccgaaggggg aaagucccuu     2580

gcucgagcac uccagcaaaa uacuucacug gagauauugu gguuaaccca gaacgagcug     2640

aaugaugagg uggccgaaag ucucgcugag augcugaaag ugaaccagac acuuaagcau     2700

cugugguuga uucaaaacca gaucaccgcc aaggguacug cacagcuagc ggacgcccug     2760

cagagcaaua caggcaucac ggaaauuugc cucaacggga aucugaucaa accagaggag     2820

gcuaaggucu augaagauga gaaacgcauu auauguuuuu ga                        2862


<210>  9156
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD1__Homo_sapiens__AAD28350

<400>  9156
auggaggagc agggccacag cgagauggag aucaucccca gcgagagcca cccccacauc       60

cagcugcuga agagcaacag agagcugcug gugacccaca ucagaaacac ccagugccug      120

guggacaacc ugcugaagaa cgacuacuuc agcgccgagg acgccgagau cgugugcgcc      180

ugccccaccc agcccgacaa ggugagaaag auccuggacc uggugcagag caagggcgag      240

gaggugagcg aguucuuccu guaccugcug cagcagcugg ccgacgccua cguggaccug      300

agacccuggc ugcuggagau cggcuucagc cccagccugc ugacccagag caagguggug      360

gugaacaccg accccgugag cagauacacc cagcagcuga gacaccaccu gggcagagac      420

agcaaguucg ugcugugcua cgcccagaag gaggagcugc ugcuggagga gaucuacaug      480

gacaccauca uggagcuggu gggcuucagc aacgagagcc ugggcagccu gaacagccug      540

gccugccugc uggaccacac caccggcauc cugaacgagc agggcgagac caucuucauc      600

cugggcgacg ccggcguggg caagagcaug cugcugcaga gacugcagag ccugugggcc      660

accggcagac uggacgccgg cgugaaguuc uucuuccacu ucagaugcag aauguucagc      720

ugcuucaagg agagcgacag acugugccug caggaccugc uguucaagca cuacugcuac      780

cccgagagag accccgagga gguguucgcc uuccugcuga gauuccccca cguggcccug      840

uucaccuucg acggccugga cgagcugcac agcgaccugg accugagcag agugcccgac      900

agcagcugcc ccugggagcc cgcccacccc cuggugcugc uggccaaccu gcugagcggc      960

aagcugcuga agggcgccag caagcugcug accgccagaa ccggcaucga ggugcccaga     1020

caguuccuga gaaagaaggu gcugcugaga ggcuucagcc ccagccaccu gagagccuac     1080

gccagaagaa uguuccccga gagagcccug caggacagac ugcugagcca gcuggaggcc     1140

aaccccaacc ugugcagccu gugcagcgug ccccuguucu gcuggaucau cuucagaugc     1200

uuccagcacu ucagagccgc cuucgagggc agcccccagc ugcccgacug caccaugacc     1260

cugaccgacg uguuccugcu ggugaccgag gugcaccuga acagaaugca gcccagcagc     1320

cuggugcaga gaaacaccag aagccccgug gagacccugc acgccggcag agacacccug     1380

ugcagccugg gccagguggc ccacagaggc auggagaaga gccuguucgu guucacccag     1440

gaggaggugc aggccagcgg ccugcaggag agagacaugc agcugggcuu ccugagagcc     1500

cugcccgagc ugggccccgg cggcgaccag cagagcuacg aguucuucca ccugacccug     1560

caggccuucu ucaccgccuu cuuccuggug cuggacgaca gagugggcac ccaggagcug     1620

cugagauucu uccaggagug gaugcccccc gccggcgccg ccaccaccag cugcuacccc     1680

cccuuccugc ccuuccagug ccugcagggc agcggccccg ccagagagga ccuguucaag     1740

aacaaggacc acuuccaguu caccaaccug uuccugugcg gccugcugag caaggccaag     1800

cagaagcugc ugagacaccu ggugcccgcc gccgcccuga gaagaaagag aaaggcccug     1860

ugggcccacc uguucagcag ccugagaggc uaccugaaga gccugcccag agugcaggug     1920

gagagcuuca accaggugca ggccaugccc accuucaucu ggaugcugag augcaucuac     1980

gagacccaga gccagaaggu gggccagcug gccgccagag gcaucugcgc caacuaccug     2040

aagcugaccu acugcaacgc cugcagcgcc gacugcagcg cccugagcuu cgugcugcac     2100

cacuucccca agagacuggc ccuggaccug gacaacaaca accugaacga cuacggcgug     2160

agagagcugc agcccugcuu cagcagacug accgugcuga gacugagcgu gaaccagauc     2220

accgacggcg gcgugaaggu gcugagcgag gagcugacca aguacaagau cgugaccuac     2280

cugggccugu acaacaacca gaucaccgac gugggcgcca gauacgugac caagauccug     2340

gacgagugca agggccugac ccaccugaag cugggcaaga acaagaucac cagcgagggc     2400

ggcaaguacc uggcccuggc cgugaagaac agcaagagca ucagcgaggu gggcaugugg     2460

ggcaaccagg ugggcgacga gggcgccaag gccuucgccg aggcccugag aaaccacccc     2520

agccugacca cccugagccu ggccagcaac ggcaucagca ccgagggcgg caagagccug     2580

gccagagccc ugcagcagaa caccagccug gagauccugu ggcugaccca gaacgagcug     2640

aacgacgagg uggccgagag ccuggccgag augcugaagg ugaaccagac ccugaagcac     2700

cuguggcuga uccagaacca gaucaccgcc aagggcaccg cccagcuggc cgacgcccug     2760

cagagcaaca ccggcaucac cgagaucugc cugaacggca accugaucaa gcccgaggag     2820

gccaaggugu acgaggacga gaagagaauc aucugcuucu ga                        2862


<210>  9157
<211>  2862
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD1__Homo_sapiens__AAD28350

<400>  9157
auggaggaac agggccacag cgagauggaa aucauucccu ccgagucuca uccucacauc       60

caacugcuca agagcaacag agaacugcuu gugacccaua uucggaauac acagugccug      120

gucgacaacc uccugaaaaa ugauuacuuc uccgccgagg acgcugagau cguuugugcc      180

ugcccgacgc agcccgauaa ggugcgcaaa auucuugacc uggugcaguc uaagggggaa      240

gaggucagcg aauuuuuccu cuaucugcug caacagcucg cggaugcuua cguggaccug      300

agaccuuggc uucuggagau cggauuuucc cccucucucc ugacccagag caaaguugug      360

gucaacacag auccuguguc ccgguauacc cagcaacuuc gccaccaucu gggcagagac      420

agcaaguucg uucucuguua cgcccagaag gaggaacugc ugcucgagga aaucuauaug      480

gauacaauua uggagcuggu gggguuuucu aaugaauccc uuggaagccu gaacucucuc      540

gccugccugc uugaccacac cacaggcauc cugaaugagc agggggagac cauuuucauc      600

cucggagaug cuggcgucgg caaauccaug cugcugcagc ggcuccaaag ccugugggcc      660

acggggcgcc uugacgcugg agugaaguuu uucuuucacu ucagaugucg gauguuuucu      720

ugcuucaaag aauccgaucg ccugugucuc caggaccugc uuuuuaagca uuacugcuau      780

cccgagagag acccugaaga gguguucgcc uuccugcucc gguuuccgca cgucgcgcug      840

uucaccuuug auggccugga cgaacuccau agcgaucugg accuuucccg cguucccgau      900

ucuagcuguc cuugggagcc cgcccacccu cuggugcucc uggcuaaccu gcuuuccggg      960

aaacuccuga agggagccag caagcugcuc acagcuagaa ccggcauuga ggugccccgg     1020

caguuccugc gcaaaaaggu ccuucugaga ggguuuucuc cgucccaccu ccgggccuac     1080

gcgagacgca uguucccuga acgggcccug caagacagac ugcuuagcca gcucgaggcu     1140

aaucccaacc ugugcucucu guguagcgug ccucucuuuu gcuggaucau uuuccgcugc     1200

uuucagcauu uccgggccgc uuuugaagga agcccccagc ugcccgauug uacaaugacc     1260

cuuacggacg uuuuccugcu cgugacagag guccaccuga auagaaugca accuucuagc     1320

cuggugcagc gcaacacccg guccccgguu gaaacacuuc augccggcag agauacccuc     1380

ugcagccugg gccagguggc ccaccgcggg auggagaaau cucuguuugu cuucacccag     1440

gaggaagugc aggcuuccgg acuccaagag cgggacaugc agcugggcuu ccuuagagcg     1500

cugcccgaac ucgggccugg aggcgaucag caaagcuacg aguuuuucca ucugacacug     1560

caggccuuuu ucacggccuu uuuccuuguc cucgacgacc gcguggggac ccaggagcug     1620

cugcgguuuu uccaggaaug gaugcccccu gcuggagccg cuacaaccuc uuguuauccc     1680

ccguuucucc cuuuccaaug ccugcagggc uccggccccg ccagagagga ucuuuuuaag     1740

aauaaagacc acuuccaguu uacaaaccug uuccucugug ggcugcugag caaggcgaaa     1800

caaaaacuuc ugcggcaccu cguuccugcu gccgcccugc gcagaaagcg gaaagcucuc     1860

ugggcccauc uguucuccuc ucuuagagga uaccugaagu cccucccccg cgugcagguc     1920

gaauccuuua aucaggugca ggcuaugccu accuucaucu ggaugcugcg gugcaucuau     1980

gagacgcaau cucagaaagu uggccagcug gccgcgagag ggauuugugc caacuaccuu     2040

aagcugacau auugcaacgc uuguagcgcc gauugcuccg cucucagcuu ugugcugcac     2100

cauuucccca aacgccucgc ccuggaccuu gauaauaaca aucugaacga cuacggaguc     2160

agagaacucc agccguguuu uucucggcug accgugcugc gccuuuccgu gaaucaaauc     2220

accgauggcg ggguuaaggu ccugagcgag gagcucacaa aguauaaaau ugugaccuac     2280

cugggccucu acaacaauca gaucacagac gugggagcga gauaugucac gaagauucug     2340

gaugaaugca aaggccuuac ccaccugaag cuggggaaaa acaagaucac aucugaggga     2400

ggcaaguacc ucgcccuggc ugugaaaaau uccaagagca ucucugaagu ugggaugugg     2460

ggaaaccagg ugggcgacga gggggccaag gcuuucgccg aagcccuucg gaaucacccu     2520

agccugacca cacucucccu ggcuagcaac ggcauuucua ccgagggagg caagucccuc     2580

gcgcgcgccc ugcagcaaaa uacgagccuu gagauccugu ggcugaccca gaacgaacuc     2640

aaugaugagg ucgcugaauc ccuggccgag augcuuaaag ugaaccagac acugaagcau     2700

cucuggcuga uucaaaacca gaucaccgcc aaggggacag cucagcucgc cgacgcgcug     2760

cagucuaaua ccggaauuac ggaaaucugc cuuaacggca aucugaucaa acccgaggag     2820

gcuaagguuu augaagauga gaaaagaauu aucuguuuuu ga                        2862


<210>  9158
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD2__Homo_sapiens__Q9HC29

<400>  9158

Met Gly Glu Glu Gly Gly Ser Ala Ser His Asp Glu Glu Glu Arg Ala 
1               5                   10                  15      


Ser Val Leu Leu Gly His Ser Pro Gly Cys Glu Met Cys Ser Gln Glu 
            20                  25                  30          


Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu Leu Leu Val Ser Gly 
        35                  40                  45              


Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp Leu Leu Ser Trp Glu 
    50                  55                  60                  


Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr Val Trp Asn Lys Gly 
                85                  90                  95      


Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala Gln Glu Ala Gln Ala 
            100                 105                 110         


Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp Asp Pro His Ser Leu 
        115                 120                 125             


His Pro Ala Arg Asp Leu Gln Ser His Arg Pro Ala Ile Val Arg Arg 
    130                 135                 140                 


Leu His Ser His Val Glu Asn Met Leu Asp Leu Ala Trp Glu Arg Gly 
145                 150                 155                 160 


Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg Leu Pro Ile Phe Thr 
                165                 170                 175     


Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val Gln Glu Leu Pro Val 
        195                 200                 205             


Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys Lys Lys Tyr Met Ala 
    210                 215                 220                 


Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg Phe Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile Tyr Thr Glu Asn Val 
                245                 250                 255     


Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly Pro Pro Gln Lys Ser 
            260                 265                 270         


Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser Thr Pro Gly His Leu 
        275                 280                 285             


Asn Asp Asp Ala Asp Thr Val Leu Val Val Gly Glu Ala Gly Ser Gly 
    290                 295                 300                 


Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu Trp Ala Ala Gly Gln 
305                 310                 315                 320 


Asp Phe Gln Glu Phe Leu Phe Val Phe Pro Phe Ser Cys Arg Gln Leu 
                325                 330                 335     


Gln Cys Met Ala Lys Pro Leu Ser Val Arg Thr Leu Leu Phe Glu His 
            340                 345                 350         


Cys Cys Trp Pro Asp Val Gly Gln Glu Asp Ile Phe Gln Leu Leu Leu 
        355                 360                 365             


Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp Gly Phe Asp Glu Phe 
    370                 375                 380                 


Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys Ser Pro Thr Asp Pro 
385                 390                 395                 400 


Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu Gln Gly Asn Leu Leu 
                405                 410                 415     


Lys Asn Ala Arg Lys Val Val Thr Ser Arg Pro Ala Ala Val Ser Ala 
            420                 425                 430         


Phe Leu Arg Lys Tyr Ile Arg Thr Glu Phe Asn Leu Lys Gly Phe Ser 
        435                 440                 445             


Glu Gln Gly Ile Glu Leu Tyr Leu Arg Lys Arg His His Glu Pro Gly 
    450                 455                 460                 


Val Ala Asp Arg Leu Ile Arg Leu Leu Gln Glu Thr Ser Ala Leu His 
465                 470                 475                 480 


Gly Leu Cys His Leu Pro Val Phe Ser Trp Met Val Ser Lys Cys His 
                485                 490                 495     


Gln Glu Leu Leu Leu Gln Glu Gly Gly Ser Pro Lys Thr Thr Thr Asp 
            500                 505                 510         


Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu His Ala Thr Pro Pro 
        515                 520                 525             


Asp Ser Ala Ser Gln Gly Leu Gly Pro Ser Leu Leu Arg Gly Arg Leu 
    530                 535                 540                 


Pro Thr Leu Leu His Leu Gly Arg Leu Ala Leu Trp Gly Leu Gly Met 
545                 550                 555                 560 


Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val Ser 
                565                 570                 575     


Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val Val 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln Cys 
        595                 600                 605             


Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro Ala 
    610                 615                 620                 


Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro Met 
625                 630                 635                 640 


Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys Asp 
                645                 650                 655     


Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu Gln 
            660                 665                 670         


Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp Gly 
        675                 680                 685             


Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg Gln 
    690                 695                 700                 


Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe His 
705                 710                 715                 720 


Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala Met 
                725                 730                 735     


Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu Glu 
            740                 745                 750         


Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu Lys 
        755                 760                 765             


Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala Phe 
    770                 775                 780                 


Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr Asn 
785                 790                 795                 800 


Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly Val 
                805                 810                 815     


Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly Ile 
            820                 825                 830         


Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys Leu 
        835                 840                 845             


Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met Ala 
    850                 855                 860                 


Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Leu Gly Asn 
865                 870                 875                 880 


Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu Gly Leu Arg 
                885                 890                 895     


Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn Arg Val Gly 
            900                 905                 910         


Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp His Gln Ser 
        915                 920                 925             


Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser Val Gly Ala 
    930                 935                 940                 


Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu Glu Glu Leu 
945                 950                 955                 960 


Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys Ser Leu Ala 
                965                 970                 975     


Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys Leu Ser Asn 
            980                 985                 990         


Asn Cys Ile Thr Tyr Leu Gly Ala Glu Ala Leu Leu Gln Ala Leu Glu 
        995                 1000                1005            


Arg Asn Asp Thr Ile Leu Glu Val Trp Leu Arg Gly Asn Thr Phe Ser 
    1010                1015                1020                


Leu Glu Glu Val Asp Lys Leu Gly Cys Arg Asp Thr Arg Leu Leu Leu 
1025                1030                1035                1040






<210>  9159
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD2__Homo_sapiens__AAG33677

<400>  9159
augggggaag agggugguuc agccucucac gaugaggagg aaagagcaag uguccuccuc       60

ggacauucuc cggguuguga aaugugcucg caggaggcuu uucaggcaca gaggagccag      120

cuggucgagc ugcuggucuc agggucccug gaaggcuucg agaguguccu ggacuggcug      180

cuguccuggg agguccucuc cugggaggac uacgagggcu uccaccuccu gggccagccu      240

cucucccacu uggccaggcg ccuucuggac accgucugga auaaggguac uugggccugu      300

cagaagcuca ucgcggcugc ccaagaagcc caggccgaca gccagucccc caagcugcau      360

ggcugcuggg acccccacuc gcuccaccca gcccgagacc ugcagaguca ccggccagcc      420

auugucagga ggcuccacag ccauguggag aacaugcugg accuggcaug ggagcggggu      480

uucgucagcc aguaugaaug ugaugaaauc agguugccga ucuucacacc gucccagagg      540

gcaagaaggc ugcuugaucu ugccacggug aaagcgaaug gauuggcugc cuuccuucua      600

caacauguuc aggaauuacc agucccauug gcccugccuu uggaagcugc cacaugcaag      660

aaguauaugg ccaagcugag gaccacggug ucugcucagu cucgcuuccu caguaccuau      720

gauggagcag agacgcucug ccuggaggac auauacacag agaauguccu ggaggucugg      780

gcagaugugg gcauggcugg acccccgcag aagagcccag ccacccuggg ccuggaggag      840

cucuucagca ccccuggcca ccucaaugac gaugcggaca cugugcuggu ggugggugag      900

gcgggcagug gcaagagcac gcuccugcag cggcugcacu ugcugugggc ugcagggcaa      960

gacuuccagg aauuucucuu ugucuuccca uucagcugcc ggcagcugca gugcauggcc     1020

aaaccacucu cugugcggac ucuacucuuu gagcacugcu guuggccuga uguuggucaa     1080

gaagacaucu uccaguuacu ccuugaccac ccugaccgug uccuguuaac cuuugauggc     1140

uuugacgagu ucaaguucag guucacggau cgugaacgcc acugcucccc gaccgacccc     1200

accucugucc agacccugcu cuucaaccuu cugcagggca accugcugaa gaaugcccgc     1260

aaggugguga ccagccgucc ggccgcugug ucggcguucc ucaggaagua cauccgcacc     1320

gaguucaacc ucaagggcuu cucugaacag ggcaucgagc uguaccugag gaagcgccau     1380

caugagcccg ggguggcgga ccgccucauc cgccugcucc aagagaccuc agcccugcac     1440

gguuugugcc accugccugu cuucucaugg auggugucca aaugccacca ggaacuguug     1500

cugcaggagg gggggucccc aaagaccacu acagauaugu accugcugau ucugcagcau     1560

uuucugcugc augccacccc cccagacuca gcuucccaag gucugggacc cagucuucuu     1620

cggggccgcc uccccacccu ccugcaccug ggcagacugg cucugugggg ccugggcaug     1680

ugcugcuacg uguucucagc ccagcagcuc caggcagcac aggucagccc ugaugacauu     1740

ucucuuggcu uccuggugcg ugccaaaggu gucgugccag ggaguacggc gccccuggaa     1800

uuccuucaca ucacuuucca gugcuucuuu gccgcguucu accuggcacu cagugcugau     1860

gugccaccag cuuugcucag acaccucuuc aauuguggca ggccaggcaa cucaccaaug     1920

gccaggcucc ugcccacgau gugcauccag gccucggagg gaaaggacag cagcguggca     1980

gcuuugcugc agaaggccga gccgcacaac cuucagauca cagcagccuu ccuggcaggg     2040

cuguuguccc gggagcacug gggccugcug gcugagugcc agacaucuga gaaggcccug     2100

cuccggcgcc aggccugugc ccgcuggugu cuggcccgca gccuccgcaa gcacuuccac     2160

uccaucccgc cagcugcacc gggugaggcc aagagcgugc augccaugcc cggguucauc     2220

uggcucaucc ggagccugua cgagaugcag gaggagcggc uggcucggaa ggcugcacgu     2280

ggccugaaug uugggcaccu caaguugaca uuuugcagug ugggccccac ugagugugcu     2340

gcccuggccu uugugcugca gcaccuccgg cggcccgugg cccugcagcu ggacuacaac     2400

ucugugggug acauuggcgu ggagcagcug cugccuugcc uuggugucug caaggcucug     2460

uauuugcgcg auaacaauau cucagaccga ggcaucugca agcucauuga augugcucuu     2520

cacugcgagc aauugcagaa guuagcucua uucaacaaca aauugacuga cggcugugca     2580

cacuccaugg cuaagcuccu ugcaugcagg cagaacuucu uggcauugag gcuggggaau     2640

aacuacauca cugccgcggg agcccaagug cuggccgagg ggcuccgagg caacaccucc     2700

uugcaguucc ugggauucug gggcaacaga gugggugacg agggggccca ggcccuggcu     2760

gaagccuugg gugaucacca gagcuugagg uggcucagcc ugguggggaa caacauuggc     2820

agugugggug cccaagccuu ggcacugaug cuggcaaaga acgucaugcu agaagaacuc     2880

ugccuggagg agaaccaucu ccaggaugaa gguguauguu cucucgcaga aggacugaag     2940

aaaaauucaa guuugaaaau ccugaaguug uccaauaacu gcaucaccua ccuaggggca     3000

gaagcccucc ugcaggcccu ugaaaggaau gacaccaucc uggaagucug gcuccgaggg     3060

aacacuuucu cucuagagga gguugacaag cucggcugca gggacaccag acucuugcuu     3120

uga                                                                   3123


<210>  9160
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD2__Homo_sapiens__AAG33677

<400>  9160
augggcgagg agggcgggag cgccucccac gacgaggagg agcgcgccag cgugcugcuc       60

gggcacuccc ccggcugcga gaugugcagc caggaggcgu uccaggccca gcggucccag      120

cuggucgagc ugcucgugag cgggucccug gagggcuucg agagcgugcu ggacuggcuc      180

cuguccuggg agguccugag cugggaggac uacgagggcu uccaccuccu ggggcagccg      240

cugucccacc ucgcccgccg gcugcuggac accgugugga acaagggcac cugggccugc      300

cagaagcuca ucgccgcggc ccaggaggcc caggccgaca gccagucccc caagcugcac      360

gggugcuggg acccccacag ccugcacccc gcgcgcgacc uccaguccca ccggccggcc      420

aucgugcgcc ggcugcacag ccacgucgag aacaugcugg accucgccug ggagcgcggc      480

uucguguccc aguacgagug cgacgagauc cggcugccca ucuucacgcc cagccagcgc      540

gcccggcgcc ugcucgaccu ggccaccgug aaggcgaacg ggcuggccgc cuuccuccug      600

cagcacgucc aggagcugcc cgugccgcuc gcccugcccc uggaggccgc gaccugcaag      660

aaguacaugg ccaagcuccg gaccacggug uccgcccaga gccgcuuccu gagcaccuac      720

gacggcgccg agacccugug ccucgaggac aucuacaccg agaacguccu ggaggugugg      780

gccgacgugg gcauggcggg gccgccccag aagucccccg ccacgcuggg ccucgaggag      840

cuguucagca cccccgggca ccugaacgac gacgccgaca ccguccucgu ggugggcgag      900

gccggcuccg gcaagagcac ccugcugcag cggcuccacc uccugugggc cgcggggcag      960

gacuuccagg aguuccucuu cgucuucccc uucuccugcc gccagcugca gugcauggcc     1020

aagccccuga gcgugcggac gcugcuguuc gagcacugcu gcuggccgga cguggggcag     1080

gaggacaucu uccagcugcu gcucgaccac cccgaccgcg uccugcugac cuucgacggc     1140

uucgacgagu ucaaguuccg guucaccgac cgcgagcggc acugcucccc caccgacccc     1200

acgagcgugc agacccuccu guucaaccug cuccagggga accugcugaa gaacgcccgc     1260

aaggugguca ccucccgccc ggccgcggug agcgccuucc uccggaagua cauccgcacc     1320

gaguucaacc ugaagggcuu cuccgagcag ggcaucgagc uguaccuccg gaagcgccac     1380

cacgagcccg gggucgccga ccggcugauc cgccugcucc aggagacgag cgcccugcac     1440

ggccugugcc accuccccgu guucuccugg auggugagca agugccacca ggagcugcug     1500

cuccaggagg gcgggucccc caagaccacc accgacaugu accugcugau ccuccagcac     1560

uuccugcugc acgccacgcc gcccgacagc gcgucccagg ggcucggccc cagccugcug     1620

cggggccgcc uccccacccu gcugcaccuc gggcggcugg cccugugggg ccucgggaug     1680

ugcugcuacg ucuucuccgc ccagcagcug caggccgccc aggugagccc ggacgacauc     1740

agccugggcu uccucgugcg cgcgaagggg gucgugcccg gcuccaccgc gccccuggag     1800

uuccugcaca ucaccuucca gugcuucuuc gccgccuucu accucgcccu gagcgcggac     1860

gugccgcccg cccugcuccg gcaccuguuc aacugcggcc gccccgggaa cucccccaug     1920

gcccggcugc ucccgacgau gugcauccag gccagcgagg gcaaggacuc cagcgucgcg     1980

gcccugcugc agaaggccga gccccacaac cuccagauca ccgccgccuu ccuggcgggg     2040

cugcucuccc gcgagcacug gggccugcug gccgagugcc agaccagcga gaaggcccuc     2100

cugcggcgcc aggccugcgc ccgguggugc cuggcgcgcu cccuccggaa gcacuuccac     2160

agcaucccgc ccgccgcccc cggcgaggcc aaguccgugc acgccaugcc cggguucauc     2220

uggcugaucc gcagccugua cgagaugcag gaggagcgcc ucgcgcggaa ggccgcccgc     2280

ggccugaacg uggggcaccu gaagcucacc uucugcuccg ucggccccac ggagugcgcc     2340

gcgcuggccu ucgugcugca gcaccuccgg cgccccgugg cccugcagcu ggacuacaac     2400

agcgucgggg acaucggcgu ggagcagcuc cugccgugcc ugggcgugug caaggcccuc     2460

uaccugcggg acaacaacau cuccgaccgc gggaucugca agcugaucga gugcgcccuc     2520

cacugcgagc agcugcagaa gcuggcccuc uucaacaaca agcugaccga cggcugcgcc     2580

cacagcaugg ccaagcugcu cgccugccgg cagaacuucc uggcccugcg ccucgggaac     2640

aacuacauca ccgcggccgg cgcccagguc cuggccgagg ggcugcgggg caacaccucc     2700

cuccaguucc ugggcuucug ggggaaccgc gugggcgacg agggggccca ggcgcuggcc     2760

gaggcccugg gcgaccacca gagccuccgg uggcugagcc ugguggggaa caacaucggc     2820

uccgucggcg cccaggcccu cgcgcugaug cuggccaaga acgugaugcu cgaggagcug     2880

ugccuggagg agaaccaccu ccaggacgag ggggugugca gccuggccga gggccugaag     2940

aagaacucca gccucaagau ccugaagcug uccaacaacu gcaucacgua ccucggggcc     3000

gaggcgcugc ugcaggcccu cgagcgcaac gacaccaucc uggaggucug gcugcggggc     3060

aacaccuuca gccucgagga gguggacaag cuggggugcc gcgacacccg gcugcuccug     3120

uga                                                                   3123


<210>  9161
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD2__Homo_sapiens__AAG33677

<400>  9161
augggcgagg agggcggcuc cgccucccac gacgaggagg agcgcgccuc cguccuccuc       60

ggccacuccc ccggcugcga gaugugcucc caggaggccu uccaggccca gcgcucccag      120

cucgucgagc uccucgucuc cggcucccuc gagggcuucg aguccguccu cgacuggcuc      180

cucuccuggg agguccucuc cugggaggac uacgagggcu uccaccuccu cggccagccc      240

cucucccacc ucgcccgccg ccuccucgac accgucugga acaagggcac cugggccugc      300

cagaagcuca ucgccgccgc ccaggaggcc caggccgacu cccagucccc caagcuccac      360

ggcugcuggg acccccacuc ccuccacccc gcccgcgacc uccaguccca ccgccccgcc      420

aucguccgcc gccuccacuc ccacgucgag aacaugcucg accucgccug ggagcgcggc      480

uucgucuccc aguacgagug cgacgagauc cgccucccca ucuucacccc cucccagcgc      540

gcccgccgcc uccucgaccu cgccaccguc aaggccaacg gccucgccgc cuuccuccuc      600

cagcacgucc aggagcuccc cgucccccuc gcccuccccc ucgaggccgc caccugcaag      660

aaguacaugg ccaagcuccg caccaccguc uccgcccagu cccgcuuccu cuccaccuac      720

gacggcgccg agacccucug ccucgaggac aucuacaccg agaacguccu cgaggucugg      780

gccgacgucg gcauggccgg ccccccccag aagucccccg ccacccucgg ccucgaggag      840

cucuucucca cccccggcca ccucaacgac gacgccgaca ccguccucgu cgucggcgag      900

gccggcuccg gcaaguccac ccuccuccag cgccuccacc uccucugggc cgccggccag      960

gacuuccagg aguuccucuu cgucuucccc uucuccugcc gccagcucca gugcauggcc     1020

aagccccucu ccguccgcac ccuccucuuc gagcacugcu gcuggcccga cgucggccag     1080

gaggacaucu uccagcuccu ccucgaccac cccgaccgcg uccuccucac cuucgacggc     1140

uucgacgagu ucaaguuccg cuucaccgac cgcgagcgcc acugcucccc caccgacccc     1200

accuccgucc agacccuccu cuucaaccuc cuccagggca accuccucaa gaacgcccgc     1260

aaggucguca ccucccgccc cgccgccguc uccgccuucc uccgcaagua cauccgcacc     1320

gaguucaacc ucaagggcuu cuccgagcag ggcaucgagc ucuaccuccg caagcgccac     1380

cacgagcccg gcgucgccga ccgccucauc cgccuccucc aggagaccuc cgcccuccac     1440

ggccucugcc accuccccgu cuucuccugg auggucucca agugccacca ggagcuccuc     1500

cuccaggagg gcggcucccc caagaccacc accgacaugu accuccucau ccuccagcac     1560

uuccuccucc acgccacccc ccccgacucc gccucccagg gccucggccc cucccuccuc     1620

cgcggccgcc uccccacccu ccuccaccuc ggccgccucg cccucugggg ccucggcaug     1680

ugcugcuacg ucuucuccgc ccagcagcuc caggccgccc aggucucccc cgacgacauc     1740

ucccucggcu uccucguccg cgccaagggc gucguccccg gcuccaccgc cccccucgag     1800

uuccuccaca ucaccuucca gugcuucuuc gccgccuucu accucgcccu cuccgccgac     1860

gucccccccg cccuccuccg ccaccucuuc aacugcggcc gccccggcaa cucccccaug     1920

gcccgccucc uccccaccau gugcauccag gccuccgagg gcaaggacuc cuccgucgcc     1980

gcccuccucc agaaggccga gccccacaac cuccagauca ccgccgccuu ccucgccggc     2040

cuccucuccc gcgagcacug gggccuccuc gccgagugcc agaccuccga gaaggcccuc     2100

cuccgccgcc aggccugcgc ccgcuggugc cucgcccgcu cccuccgcaa gcacuuccac     2160

uccauccccc ccgccgcccc cggcgaggcc aaguccgucc acgccaugcc cggcuucauc     2220

uggcucaucc gcucccucua cgagaugcag gaggagcgcc ucgcccgcaa ggccgcccgc     2280

ggccucaacg ucggccaccu caagcucacc uucugcuccg ucggccccac cgagugcgcc     2340

gcccucgccu ucguccucca gcaccuccgc cgccccgucg cccuccagcu cgacuacaac     2400

uccgucggcg acaucggcgu cgagcagcuc cuccccugcc ucggcgucug caaggcccuc     2460

uaccuccgcg acaacaacau cuccgaccgc ggcaucugca agcucaucga gugcgcccuc     2520

cacugcgagc agcuccagaa gcucgcccuc uucaacaaca agcucaccga cggcugcgcc     2580

cacuccaugg ccaagcuccu cgccugccgc cagaacuucc ucgcccuccg ccucggcaac     2640

aacuacauca ccgccgccgg cgcccagguc cucgccgagg gccuccgcgg caacaccucc     2700

cuccaguucc ucggcuucug gggcaaccgc gucggcgacg agggcgccca ggcccucgcc     2760

gaggcccucg gcgaccacca gucccuccgc uggcucuccc ucgucggcaa caacaucggc     2820

uccgucggcg cccaggcccu cgcccucaug cucgccaaga acgucaugcu cgaggagcuc     2880

ugccucgagg agaaccaccu ccaggacgag ggcgucugcu cccucgccga gggccucaag     2940

aagaacuccu cccucaagau ccucaagcuc uccaacaacu gcaucaccua ccucggcgcc     3000

gaggcccucc uccaggcccu cgagcgcaac gacaccaucc ucgaggucug gcuccgcggc     3060

aacaccuucu cccucgagga ggucgacaag cucggcugcc gcgacacccg ccuccuccuc     3120

uga                                                                   3123


<210>  9162
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD2__Homo_sapiens__AAG33677

<400>  9162
augggcgagg aagggggaag cgccucccac gacgaggaag agagagcuuc ugugcugcuc       60

ggucauucac ccggcugcga aauguguagu caggaggcau uccaagccca gaggagccag      120

cuugucgagc uguugguuuc cgggucuuua gaaggauuug agucggugcu ggauuggcua      180

cucucauggg aaguacugag cugggaggac uacgagggcu uccaccuucu gggucagccu      240

uugagucauc ucgcgcggcg ccugcuggau accgugugga acaaggggac augggcuugc      300

caaaaacuca ucgccgcagc ccaggaagcu caggcagacu cccagucucc aaaguuacac      360

ggauguuggg auccgcauag ccugcacccc gcccgagacc uucaauccca ccguccugcu      420

auugucagaa gguugcauuc acacguggag aauaugcugg aucuagccug ggaacggggc      480

uuuguuaguc aguaugagug cgacgaaaua cgccucccaa ucuucacucc cagccagaga      540

gcgaggcggc ugcuugaucu ggcaacggug aaagccaacg gcuuggcugc cuuucuccug      600

cagcaugucc aagaguuacc ugugccacug gcacuccccc uugaggcugc caccuguaag      660

aaauacaugg cgaagcugcg cacaacugua ucugcccagu cccgauucuu gucaaccuau      720

gacggggcag aaacacuaug ccuggaggau auuuacaccg aaaauguucu cgaggugugg      780

gcugacgucg gaauggccgg uccuccacag aagucuccgg cuacucuggg ccuugaggag      840

cuguuuagua cacccgggca cuugaacgau gacgccgaca ccgugcucgu ggucggagag      900

gcaggcucug guaaauccac gcuguuacaa agacugcacc uacucugggc cgcugggcag      960

gauuuccagg aauuucuguu cguuuuuccu uucagcugua ggcagcuuca augcauggcg     1020

aagccauugu cggugcggac ucugcucuuu gagcauuguu gcuggcccga cguaggacag     1080

gaagauaucu uccagcugcu ucuggaccac ccugaucgug uguugcucac cuucgacggc     1140

uuugaugagu ucaaauuucg cuucacagac agagaaaggc auuguucucc aacugauccc     1200

accuccgucc agacacuguu auuuaaucug cuacaaggca accuccugaa gaaugcacgg     1260

aaagugguua ccucacgacc ggccgcugug agugccuucc uucgcaagua uauuagaacg     1320

gaguuuaacu ugaagggguu cagcgagcag ggaaucgaac uguaccucag gaaacggcac     1380

caugagccug gugucgcaga ccgccugaua agauuacugc aggaaacuuc cgcccuucac     1440

ggcuugugcc accuccccgu guuuucuugg augguaagca agugccauca ggagcugcua     1500

cugcaagaag ggggaucacc aaaaacaacc acugauaugu aucuccugau ccuucagcac     1560

uucuugcugc augcuacacc ucccgacagu gccucccagg gcuuaggucc aagccuccug     1620

agggggcguc uucccacccu guugcaccuc ggccggcugg cacuaugggg acugggcaug     1680

uguugcuacg uuuuuagcgc gcagcaacuc caggcugccc aggugucacc ugacgauauu     1740

agucuggggu uccuuguccg agcaaaggga guggucccag guagcacggc cccguuggaa     1800

uuucugcaca ucaccuucca auguuucuuu gcugccuucu acuuagcacu cuccgcugac     1860

gugcccccug cccugcuuag acaucuguuu aauugcggca ggccagggaa cucucccaug     1920

gcgcgccuac ucccuacaau guguauucag gccucggagg gaaaagauag cuccguugcu     1980

gcacuguugc agaaggccga accacacaau cugcagauca cugcugccuu cuuagcaggc     2040

cuccugucac gggagcauug gggucuucug gcggaaugcc aaaccaguga gaaagccuug     2100

cucagaaggc aggcuugugc ccgcuggugc cuggcacgau cucuacggaa gcacuuucau     2160

agcauacccc cggcugcccc uggggaggca aaguccgugc acgccaugcc aggcuucauu     2220

uggcugaucc guucacuuua ugaaaugcag gaggaaagac ucgcuaggaa agcggcccgc     2280

ggacugaacg uaggccacuu gaagcugaca uuuuguagcg ucgggcccac ugagugcgca     2340

gcuuuagccu ucgugcucca gcaucugcgg agaccuguug cccuucaacu ggacuacaau     2400

ucugugggag auauuggugu cgaacaguug cuccccuguc ugggcgugug caaagcucua     2460

uaucugaggg acaacaauau cuccgaucga gggaucugca aacuuauuga gugugcacuc     2520

cacugcgagc agcugcagaa auuggccuua uuuaacaaca agcugaccga cggaugugcg     2580

cauaguaugg cuaagcuccu ggccugccgc caaaauuucc uugcacugcg guugggcaac     2640

aauuacauaa cagccgcugg ugcacaggua cuagccgaag ggcugagagg caacaccagc     2700

cuccaguuuc ugggauucug gggcaauagg gugggggaug agggagcgca agcucuugcc     2760

gaagcauuag gcgaccacca gucucugcgu uggcucuccu ugguugguaa caauaucggg     2820

ucagucggag cccaggcucu ggcccucaug cuggcaaaga acgugaugcu ugaggaacug     2880

uguuuggagg agaaucaucu acaggaugaa ggcgugugca gucuggcuga gggucucaag     2940

aaaaacagcu cguuaaagau ucugaaacuu uccaauaacu guaucacuua ucugggcgcc     3000

gaagcgcucu ugcaagcccu ggagcgcaau gacacgauac ucgaggucug gcugcggggg     3060

aacacauuuu cucuugaaga gguugauaag cuaggaugca gagacaccag gcuguuguua     3120

uga                                                                   3123


<210>  9163
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD2__Homo_sapiens__AAG33677

<400>  9163
augggcgagg agggcggcag cgccagccac gacgaggagg agagagccag cgugcugcug       60

ggccacagcc ccggcugcga gaugugcagc caggaggccu uccaggccca gagaagccag      120

cugguggagc ugcuggugag cggcagccug gagggcuucg agagcgugcu ggacuggcug      180

cugagcuggg aggugcugag cugggaggac uacgagggcu uccaccugcu gggccagccc      240

cugagccacc uggccagaag acugcuggac accgugugga acaagggcac cugggccugc      300

cagaagcuga ucgccgccgc ccaggaggcc caggccgaca gccagagccc caagcugcac      360

ggcugcuggg acccccacag ccugcacccc gccagagacc ugcagagcca cagacccgcc      420

aucgugagaa gacugcacag ccacguggag aacaugcugg accuggccug ggagagaggc      480

uucgugagcc aguacgagug cgacgagauc agacugccca ucuucacccc cagccagaga      540

gccagaagac ugcuggaccu ggccaccgug aaggccaacg gccuggccgc cuuccugcug      600

cagcacgugc aggagcugcc cgugccccug gcccugcccc uggaggccgc caccugcaag      660

aaguacaugg ccaagcugag aaccaccgug agcgcccaga gcagauuccu gagcaccuac      720

gacggcgccg agacccugug ccuggaggac aucuacaccg agaacgugcu ggaggugugg      780

gccgacgugg gcauggccgg ccccccccag aagagccccg ccacccuggg ccuggaggag      840

cuguucagca cccccggcca ccugaacgac gacgccgaca ccgugcuggu ggugggcgag      900

gccggcagcg gcaagagcac ccugcugcag agacugcacc ugcugugggc cgccggccag      960

gacuuccagg aguuccuguu cguguucccc uucagcugca gacagcugca gugcauggcc     1020

aagccccuga gcgugagaac ccugcuguuc gagcacugcu gcuggcccga cgugggccag     1080

gaggacaucu uccagcugcu gcuggaccac cccgacagag ugcugcugac cuucgacggc     1140

uucgacgagu ucaaguucag auucaccgac agagagagac acugcagccc caccgacccc     1200

accagcgugc agacccugcu guucaaccug cugcagggca accugcugaa gaacgccaga     1260

aaggugguga ccagcagacc cgccgccgug agcgccuucc ugagaaagua caucagaacc     1320

gaguucaacc ugaagggcuu cagcgagcag ggcaucgagc uguaccugag aaagagacac     1380

cacgagcccg gcguggccga cagacugauc agacugcugc aggagaccag cgcccugcac     1440

ggccugugcc accugcccgu guucagcugg auggugagca agugccacca ggagcugcug     1500

cugcaggagg gcggcagccc caagaccacc accgacaugu accugcugau ccugcagcac     1560

uuccugcugc acgccacccc ccccgacagc gccagccagg gccugggccc cagccugcug     1620

agaggcagac ugcccacccu gcugcaccug ggcagacugg cccugugggg ccugggcaug     1680

ugcugcuacg uguucagcgc ccagcagcug caggccgccc aggugagccc cgacgacauc     1740

agccugggcu uccuggugag agccaagggc guggugcccg gcagcaccgc cccccuggag     1800

uuccugcaca ucaccuucca gugcuucuuc gccgccuucu accuggcccu gagcgccgac     1860

gugccccccg cccugcugag acaccuguuc aacugcggca gacccggcaa cagccccaug     1920

gccagacugc ugcccaccau gugcauccag gccagcgagg gcaaggacag cagcguggcc     1980

gcccugcugc agaaggccga gccccacaac cugcagauca ccgccgccuu ccuggccggc     2040

cugcugagca gagagcacug gggccugcug gccgagugcc agaccagcga gaaggcccug     2100

cugagaagac aggccugcgc cagauggugc cuggccagaa gccugagaaa gcacuuccac     2160

agcauccccc ccgccgcccc cggcgaggcc aagagcgugc acgccaugcc cggcuucauc     2220

uggcugauca gaagccugua cgagaugcag gaggagagac uggccagaaa ggccgccaga     2280

ggccugaacg ugggccaccu gaagcugacc uucugcagcg ugggccccac cgagugcgcc     2340

gcccuggccu ucgugcugca gcaccugaga agacccgugg cccugcagcu ggacuacaac     2400

agcgugggcg acaucggcgu ggagcagcug cugcccugcc ugggcgugug caaggcccug     2460

uaccugagag acaacaacau cagcgacaga ggcaucugca agcugaucga gugcgcccug     2520

cacugcgagc agcugcagaa gcuggcccug uucaacaaca agcugaccga cggcugcgcc     2580

cacagcaugg ccaagcugcu ggccugcaga cagaacuucc uggcccugag acugggcaac     2640

aacuacauca ccgccgccgg cgcccaggug cuggccgagg gccugagagg caacaccagc     2700

cugcaguucc ugggcuucug gggcaacaga gugggcgacg agggcgccca ggcccuggcc     2760

gaggcccugg gcgaccacca gagccugaga uggcugagcc uggugggcaa caacaucggc     2820

agcgugggcg cccaggcccu ggcccugaug cuggccaaga acgugaugcu ggaggagcug     2880

ugccuggagg agaaccaccu gcaggacgag ggcgugugca gccuggccga gggccugaag     2940

aagaacagca gccugaagau ccugaagcug agcaacaacu gcaucaccua ccugggcgcc     3000

gaggcccugc ugcaggcccu ggagagaaac gacaccaucc uggaggugug gcugagaggc     3060

aacaccuuca gccuggagga gguggacaag cugggcugca gagacaccag acugcugcug     3120

uga                                                                   3123


<210>  9164
<211>  3123
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD2__Homo_sapiens__AAG33677

<400>  9164
augggcgagg aagggggaag cgccucccac gacgaggaag agagagcuuc ugugcugcuc       60

ggccauagcc ccgggugcga aauguguucc caggaggccu uccaagcgca gcggucucag      120

cuggucgagc uucugguuag cggaucccuc gaaggcuuug agucugugcu ggauuggcuu      180

cugagcuggg aagugcucuc cugggaggac uacgaggggu uccaucugcu gggacagccu      240

cucagccacc uggcucgcag acuucuggau accgucugga acaagggcac augggccugc      300

caaaaacuca ucgccgcugc ccaggaagcu caggccgacu cucagucccc gaagcugcac      360

ggcuguuggg auccccauag ccuucacccu gcgcgggacc ugcaaucuca ccgccccgcc      420

auugugagac ggcuccauuc ccacguugag aauaugcugg aucuggcuug ggaacgcggg      480

uuugugagcc aguaugagug cgacgaaauc agacucccua uuuucacgcc cucucagcgg      540

gcccgcagac ugcuugaucu ggcuaccguc aaagccaacg gacucgcggc cuuucugcuu      600

cagcaugugc aagagcugcc uguuccgcuc gcucugcccc uggaggccgc uacauguaag      660

aaauacaugg ccaagcuccg gaccacagug uccgcccaga gccgcuuccu guccaccuau      720

gacggcgcug aaacacuuug ccuggaggau aucuacaccg aaaauguccu cgaggugugg      780

gcggacgugg ggauggccgg accuccccag aagucuccug cuacgcuggg ccuugaggaa      840

cuguuuagca cccccgggca ccucaacgau gacgccgaca caguccuggu ugugggagag      900

gccggcuccg gcaaaagcac ccugcuccaa agacugcacc uucugugggc ugccgggcag      960

gauuuccagg aauuucucuu cguguuuccg uucucuuguc ggcagcugca augcauggcg     1020

aagccucugu ccguccgcac acuucucuuu gagcauuguu gcuggcccga cgugggacag     1080

gaagauauuu uccagcugcu gcucgaccac ccugauagag uucugcuuac cuucgacggc     1140

uuugaugagu ucaaauuucg guucacggac agagaacgcc auuguagccc cacagauccc     1200

accucugugc agacacugcu cuuuaaucug cugcaaggga accuucucaa gaaugcucgg     1260

aaagucguga ccagcagacc ugccgccguu uccgcuuucc ugcgcaagua uauccggacc     1320

gaguuuaacc ugaagggauu cucugagcag ggcaucgaac ucuaccugag aaaacgccac     1380

caugagccgg ggguggccga ccggcuuauu agacugcucc aggaaacaag cgcucugcac     1440

ggacugugcc accuucccgu cuuuuccugg auggugagca agugccauca ggagcuccug     1500

cugcaagagg gcggcucucc uaaaacgacc acagauaugu aucuccugau ccuucagcac     1560

uuccugcucc augccacacc cccugacucc gcgagccagg ggcugggacc cucucugcuu     1620

cgcggccggc ucccgacccu gcugcaccuc gggagacugg cccuuugggg acugggcaug     1680

uguugcuacg ucuuuuccgc ucagcaacuc caggccgcuc aggugagccc ugacgauauu     1740

ucccuggggu uccugguucg cgccaagggc gugguccccg gaucuaccgc gccucuugaa     1800

uuucugcaca ucacguucca auguuucuuu gccgcuuucu accucgcccu gagcgcugac     1860

gugcccccug cccuccugcg gcaucuuuuu aauugcggca gacccgggaa cuccccgaug     1920

gcccggcugc ucccuacaau guguauucag gcuucugagg gaaaagauag cuccguugcg     1980

gcccugcugc agaaggcuga accccacaau cuucagauca ccgccgccuu ccuggcuggc     2040

cuccugagcc gcgagcauug ggggcuccug gccgaaugcc aaaccucuga gaaagcgcuu     2100

cugagacggc aggcuugugc cagauggugc cucgcccgcu cccugcggaa gcacuuucau     2160

agcauucccc cugcugcccc gggagaggcg aagucugugc acgcuaugcc cggcuucauc     2220

uggcugauca gaucccuuua ugaaaugcag gaggaacgcc uggccagaaa agccgcucgg     2280

gggcucaacg ucggccaccu gaagcucaca uuuuguagcg ugggaccuac cgagugcgcc     2340

gcucuggccu ucgugcuuca gcaucugcgc agacccguug cgcugcaacu cgacuacaau     2400

ucugucggcg auauuggggu ggaacagcug cuuccuuguc ugggagugug caaagcccuc     2460

uaucugcggg acaacaauau cagcgaucgc ggcauuugca agcucaucga gugugcucug     2520

cacugcgagc agcuucagaa acuggcccug uuuaacaaca agcucacaga cgggugugcu     2580

cauuccaugg ccaagcugcu ugccugcaga caaaauuucc uggcucuccg gcugggaaac     2640

aauuacauua cggcggccgg cgcucagguc cucgccgaag ggcugcgcgg caacaccagc     2700

cuucaguuuc ugggauucug gggcaauaga gugggggaug agggagccca agcucuggcc     2760

gaagcgcucg gcgaccacca gucucugcgg uggcuuuccc ugguugggaa caauaucgga     2820

agcgugggcg cucaggcccu cgcccugaug cucgcuaaaa acgucaugcu ggaggaacuu     2880

ugucuggagg agaaucaucu gcaggaugaa ggggugugcu cccucgccga gggccugaag     2940

aaaaacucua gccuuaagau ccugaaacuc uccaauaacu guauuacaua ucugggagcg     3000

gaagcucugc uccaagcccu ugagcgcaau gacaccaucc uggagguuug gcugagaggc     3060

aacacauuuu cucucgaaga gguggauaag cuggggugcc gggacaccag acuucugcuc     3120

uga                                                                   3123


<210>  9165
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__C3VPR7

<400>  9165

Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His 
1               5                   10                  15      


Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu 
            20                  25                  30          


Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg 
        35                  40                  45              


Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln 
    50                  55                  60                  


Arg His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu 
65                  70                  75                  80  


Gly Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu 
                85                  90                  95      


Thr Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr 
            100                 105                 110         


Arg Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe 
        115                 120                 125             


Leu Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile 
    130                 135                 140                 


Gly Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg 
145                 150                 155                 160 


Leu Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro 
                165                 170                 175     


Leu Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg 
            180                 185                 190         


Leu Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val 
        195                 200                 205             


Ala Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys 
    210                 215                 220                 


Arg Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys 
225                 230                 235                 240 


Lys Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn 
                245                 250                 255     


Leu Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser 
            260                 265                 270         


Gly Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly 
        275                 280                 285             


Phe Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu 
    290                 295                 300                 


Asp Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg 
305                 310                 315                 320 


Ala Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly 
                325                 330                 335     


Met Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala 
            340                 345                 350         


Glu Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe 
        355                 360                 365             


Arg Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro 
    370                 375                 380                 


Arg Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr 
                405                 410                 415     


Glu Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly 
            420                 425                 430         


Ala Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser 
        435                 440                 445             


Val Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala 
    450                 455                 460                 


Ala Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr 
465                 470                 475                 480 


Glu Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg 
                485                 490                 495     


Ser Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val 
            500                 505                 510         


Phe Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu 
        515                 520                 525             


Leu Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr 
    530                 535                 540                 


Gln Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val 
545                 550                 555                 560 


Cys Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His 
                565                 570                 575     


Thr Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu 
            580                 585                 590         


Ala Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu 
        595                 600                 605             


Gln Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu 
    610                 615                 620                 


Ser Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu 
                645                 650                 655     


Leu Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser 
            660                 665                 670         


Leu Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg 
        675                 680                 685             


Ser Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn 
    690                 695                 700                 


Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile 
705                 710                 715                 720 


Asn Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp 
                725                 730                 735     


Asp Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu 
            740                 745                 750         


Ser Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln 
        755                 760                 765             


Arg Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met 
    770                 775                 780                 


Phe Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu 
785                 790                 795                 800 


Ala Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn 
                805                 810                 815     


Ser Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr 
            820                 825                 830         


Asn Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro 
        835                 840                 845             


Glu Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu 
    850                 855                 860                 


Lys Asn Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg 
865                 870                 875                 880 


Ala Ile Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His 
                885                 890                 895     


Leu Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln 
            900                 905                 910         


Ala Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn 
        915                 920                 925             


Ala Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val 
    930                 935                 940                 


Asn Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser Ile Gly Ala 
945                 950                 955                 960 


Ser Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn Arg Thr Leu 
                965                 970                 975     


Glu Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala Gly Ala Lys 
            980                 985                 990         


Ala Leu Ala Asn Ala Leu Lys Val Asn Ser Ser Leu Arg Arg Leu Asn 
        995                 1000                1005            


Leu Gln Glu Asn Ser Leu Gly Met Asp Gly Ala Ile Cys Ile Ala Thr 
    1010                1015                1020                


Ala Leu Ser Gly Asn His Arg Leu Gln His Ile Asn Leu Gln Gly Asn 
1025                1030                1035                1040


His Ile Gly Asp Ser Gly Ala Arg Met Ile Ser Glu Ala Ile Lys Thr 
                1045                1050                1055    


Asn Ala Pro Thr Cys Thr Val Glu Met 
            1060                1065


<210>  9166
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__ACP40993

<400>  9166
augaggaagc aagaggugcg gacgggcagg gaggccggcc agggccacgg uacgggcucc       60

ccagccgagc aggugaaagc ccucauggau cugcuggcug ggaagggcag ucaaggcucc      120

caggccccgc aggcccugga uaggacaccg gaugccccgc uggggcccug cagcaaugac      180

ucaaggauac agaggcaccg caaggcccug cugagcaagg ugggaggugg cccggagcug      240

ggcggacccu ggcacaggcu ggccucccuc cugcuggugg agggccugac ggaccugcag      300

cugagggaac acgacuucac acagguggag gccacccgcg ggggcgggca ccccgccagg      360

accgucgccc uggaccggcu cuuccugccu cucucccggg ugucuguccc accccggguc      420

uccaucacua ucgggguggc cggcaugggc aagaccaccc uggugaggca cuucguccgc      480

cucugggccc augggcaggu cggcaaggac uucucgcugg ugcugccucu gaccuuccgg      540

gaucucaaca cccacgagaa gcugugugcc gaccgacuca ucugcucggu cuucccgcac      600

gucggggagc ccagccuggc gguggcaguc ccagccaggg cccuccugau ccuggacggc      660

uuggaugagu gcaggacgcc ucuggacuuc uccaacaccg uggccugcac ggacccaaag      720

aaggagaucc cgguggacca ccugaucacc aacaucaucc guggcaaccu cuuuccggaa      780

guuuccaucu ggaucaccuc ccgucccagu gcaucuggcc agaucccagg gggccuggug      840

gaccggauga cggagauccg gggcuuuaac gaggaggaga ucaaggugug uuuggagcag      900

auguuccccg aggaccaggc ccuucugggc uggaugcuga gccaagugca ggcugacagg      960

gcccuguacc ugaugugcac cgucccagcc uucugcaggc ucacggggau ggcgcuaggc     1020

caccuguggc gcagcaggac ggggccccag gaugcagagc uguggccccc gaggacccug     1080

ugcgagcucu acucauggua cuuuaggaug gcccucagcg gggaggggca ggagaagggc     1140

aaggcaagcc cucgcaucga gcagguggcc caugguggcc gcaagauggu ggggacauug     1200

ggccgucugg ccuuccaugg gcugcucaag aagaaauacg uguuuuacga gcaagacaug     1260

aaggcguuug guguagaccu cgcucugcug cagggcgccc cgugcagcug cuuccugcag     1320

agagaggaga cguuggcauc gucaguggcc uacugcuuca cccaccuguc ccugcaggag     1380

uuuguggcag ccgcguauua cuauggcgca uccaggaggg ccaucuucga ccucuucacu     1440

gagagcggcg uauccuggcc caggcugggc uuccucacgc auuucaggag cgcagcccag     1500

cgggccaugc aggcagagga cgggaggcug gacguguucc ugcgcuuccu cuccggccuc     1560

uugucuccga gggucaaugc ccuccuggcc ggcucccugc uggcccaagg cgagcaccag     1620

gccuaccgga cccagguggc ugagcuccug cagggcugcc ugcgccccga ugccgcaguc     1680

ugugcacggg ccaucaacgu guugcacugc cugcaugagc ugcagcacac cgagcuggcc     1740

cgcagcgugg aggaggccau ggagagcggg gcccuggcca ggcugacugg ucccgcgcac     1800

cgcgcugccc uggccuaccu ccugcaggug uccgacgccu gugcccagga ggccaaccug     1860

ucccugagcc ucagccaggg cguccuucag agccugcugc cccagcugcu cuacugccgg     1920

aagcucaggc uggacaccaa ccaguuccag gaccccguga uggagcugcu gggcagcgug     1980

cugaguggga aggacugucg cauucagaag aucagcuugg cggagaacca gaucaguaac     2040

aaaggggcca aagcucuggc cagaucccuc uuggucaaca gaagucugac cucucuggac     2100

cuccgcggua acuccauugg accacaaggg gccaaggcgc uggcagacgc uuugaagauc     2160

aaccgcaccc ugaccucccu gagccuccag ggcaacaccg uuagggauga uggugccagg     2220

uccauggcug aggccuuggc cuccaaccgg acccucucca ugcugcaccu gcagaagaac     2280

agcaucgggc ccaugggagc ccagcggaug gcagaugccu ugaagcagaa caggagucug     2340

aaagagcuca uguucuccag uaauaguauu ggugauggag gugccaaggc ccuggcugag     2400

gcccugaagg ugaaccaggg ccuggagagc cuggaccugc agagcaauuc caucagugac     2460

gcaggagugg cagcacugau gggggcccuc ugcaccaacc agacccuccu cagccucagc     2520

cuucgagaaa acuccaucag ucccgaggga gcccaggcca ucgcucaugc ccucugcgcc     2580

aacagcaccc ugaagaaccu ggaccugaca gccaaccucc uccacgacca gggugcccgg     2640

gccaucgcag uggcagugag agaaaaccgc acccucaccu cccuucaccu gcaguggaac     2700

uucauccagg ccggcgcugc ccaggcccug ggacaagcac uacagcucaa caggagccuc     2760

accagcuuag auuuacagga gaacgccauc ggggaugacg gagcgugugc gguggcccgu     2820

gcacugaagg ucaacacagc ccucacugcu cucuaucucc agguggccuc aauuggugcu     2880

ucaggcgccc aggugcuagg ggaagccuug gcugugaaca gaaccuugga gauucucgac     2940

uuaagaggaa augccauugg gguggcugga gccaaagccc uggcaaaugc ucugaaggua     3000

aacucaaguc uccggagacu caaucuucaa gagaauucuc uggggaugga cggggcgaua     3060

ugcauugcca cagcacuguc uggaaaccac aggcuccagc auaucaaucu ccagggaaac     3120

cacauugggg acuccggggc caggaugauc ucagaggcca ucaagacaaa ugcucccacg     3180

ugcacuguug aaauguga                                                   3198


<210>  9167
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD3__Homo_sapiens__ACP40993

<400>  9167
augcgcaagc aggaggugcg gaccggccgc gaggccgggc agggccacgg gaccggcagc       60

cccgccgagc aggucaaggc gcugauggac cuccuggccg ggaagggcuc ccagggcagc      120

caggccccgc aggcccugga ccggaccccc gacgcgcccc ucgggcccug cuccaacgac      180

agccgcaucc agcggcaccg caaggcccug cuguccaagg ugggcggggg cccggagcuc      240

gggggccccu ggcaccggcu ggccagccug cuccuggugg agggccugac cgaccuccag      300

cugcgcgagc acgacuucac ccaggucgag gccacccgcg ggggcgggca ccccgcccgg      360

acgguggcgc uggaccggcu guuccugccc cugucccgcg ugagcguccc gccccgggug      420

uccaucacca ucggcguggc cggcaugggg aagaccaccc ucguccgcca cuucgugcgg      480

cugugggccc acggccaggu ggggaaggac uucagccugg uccucccccu gacguuccgc      540

gaccugaaca cccacgagaa gcucugcgcc gaccggcuga ucugcuccgu guucccccac      600

gugggcgagc cgagccuggc cgucgcggug cccgcccgcg cccuccugau ccuggacggg      660

cucgacgagu gccggacgcc ccuggacuuc uccaacaccg uggccugcac cgaccccaag      720

aaggagaucc cggucgacca ccugaucacc aacaucaucc gcggcaaccu cuuccccgag      780

gugagcaucu ggaucaccuc ccggcccagc gccuccggcc agauccccgg gggccuggug      840

gaccgcauga ccgagauccg cggguucaac gaggaggaga ucaaggucug ccuggagcag      900

auguucccgg aggaccaggc gcuccugggc uggaugcuga gccaggugca ggccgaccgg      960

gcccucuacc ugaugugcac ggugcccgcc uucugccgcc ugaccgggau ggcccucggc     1020

caccuguggc ggucccgcac cggcccccag gacgcggagc uguggccccc gcggacccuc     1080

ugcgagcugu acagcuggua cuuccgcaug gcccugagcg gggagggcca ggagaagggg     1140

aaggccagcc cccggaucga gcaggucgcc cacggcgggc gcaagauggu gggcacgcuc     1200

ggccggcugg ccuuccacgg gcugcugaag aagaaguacg ucuucuacga gcaggacaug     1260

aaggcguucg gcguggaccu cgcccugcug cagggggccc ccugcuccug cuuccuccag     1320

cgcgaggaga cccuggccuc cagcguggcg uacugcuuca cccaccuguc ccuccaggag     1380

uucgucgccg ccgccuacua cuacggcgcc agccggcgcg cgaucuucga ccuguucacc     1440

gaguccggcg ugagcuggcc ccggcugggg uuccucacgc acuuccgcuc cgccgcccag     1500

cgggccaugc aggccgagga cggccgccug gacguguucc ugcgguuccu cagcgggcug     1560

cuguccccgc gcgucaacgc gcuccuggcc ggcagccugc ucgcccaggg ggagcaccag     1620

gccuaccgga cccagguggc cgagcugcug cagggcugcc uccgccccga cgcggccgug     1680

ugcgcccgcg ccaucaacgu ccugcacugc cugcacgagc uccagcacac cgagcuggcg     1740

cgguccgugg aggaggccau ggagagcggc gcccuggccc gccucaccgg gcccgcccac     1800

cgggcggccc uggccuaccu gcuccaggug uccgacgccu gcgcccagga ggcgaaccug     1860

agccuguccc ucagccaggg cguccugcag ucccugcucc cgcagcugcu guacugccgc     1920

aagcuccggc uggacacgaa ccaguuccag gaccccguga uggagcugcu cgggagcgug     1980

cugagcggca aggacugccg cauccagaag aucucccugg ccgagaacca gaucagcaac     2040

aagggggcca aggcccucgc ccggucccug cuggucaacc gcagccucac cucccuggac     2100

cugcggggca acagcaucgg cccccagggg gcgaaggccc ucgccgacgc ccugaagauc     2160

aaccgcaccc ugaccucccu cagccugcag ggcaacacgg ugcgggacga cggggcgcgc     2220

uccauggccg aggcccuggc cagcaaccgg acccucucca ugcugcaccu ccagaagaac     2280

agcaucggcc ccaugggggc ccagcgcaug gcggacgccc ucaagcagaa ccggucccug     2340

aaggagcuga uguucagcuc caacagcauc ggcgacggcg gggccaaggc ccucgccgag     2400

gcgcugaagg ugaaccaggg ccuggagucc cucgaccugc agagcaacag caucuccgac     2460

gccggggucg ccgcccugau gggcgcccuc ugcaccaacc agacccugcu gagccucucc     2520

cugcgcgaga acagcaucuc cccggagggg gcgcaggcca ucgcccacgc ccugugcgcc     2580

aacagcacgc ucaagaaccu ggaccugacc gcgaaccucc ugcacgacca gggcgcccgg     2640

gccaucgccg uggcggugcg cgagaaccgg acccugaccu cccuccaccu ccaguggaac     2700

uucauccagg ccggcgccgc ccaggcccug gggcaggcgc ugcagcugaa ccgcagccug     2760

accucccucg accugcagga gaacgccauc ggcgacgacg gggccugcgc cgucgcccgg     2820

gcgcugaagg ugaacacggc ccucaccgcc cuguaccucc agguggccag caucggcgcc     2880

uccggcgcgc agguccuggg ggaggcccug gccgugaacc gcacccugga gauccuggac     2940

cuccgcggca acgccaucgg gguggcgggc gccaaggccc uggccaacgc ccugaagguc     3000

aacagcuccc uccggcgccu gaaccugcag gagaacagcc ucgggaugga cggcgcgauc     3060

ugcaucgcca ccgcccuguc cggcaaccac cggcugcagc acaucaaccu ccaggggaac     3120

cacaucggcg acagcggggc ccgcaugauc uccgaggcca ucaagacgaa cgcgcccacg     3180

ugcaccgugg agauguga                                                   3198


<210>  9168
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD3__Homo_sapiens__ACP40993

<400>  9168
augcgcaagc aggagguccg caccggccgc gaggccggcc agggccacgg caccggcucc       60

cccgccgagc aggucaaggc ccucauggac cuccucgccg gcaagggcuc ccagggcucc      120

caggcccccc aggcccucga ccgcaccccc gacgcccccc ucggccccug cuccaacgac      180

ucccgcaucc agcgccaccg caaggcccuc cucuccaagg ucggcggcgg ccccgagcuc      240

ggcggccccu ggcaccgccu cgccucccuc cuccucgucg agggccucac cgaccuccag      300

cuccgcgagc acgacuucac ccaggucgag gccacccgcg gcggcggcca ccccgcccgc      360

accgucgccc ucgaccgccu cuuccucccc cucucccgcg ucuccguccc cccccgcguc      420

uccaucacca ucggcgucgc cggcaugggc aagaccaccc ucguccgcca cuucguccgc      480

cucugggccc acggccaggu cggcaaggac uucucccucg uccucccccu caccuuccgc      540

gaccucaaca cccacgagaa gcucugcgcc gaccgccuca ucugcuccgu cuucccccac      600

gucggcgagc ccucccucgc cgucgccguc cccgcccgcg cccuccucau ccucgacggc      660

cucgacgagu gccgcacccc ccucgacuuc uccaacaccg ucgccugcac cgaccccaag      720

aaggagaucc ccgucgacca ccucaucacc aacaucaucc gcggcaaccu cuuccccgag      780

gucuccaucu ggaucaccuc ccgccccucc gccuccggcc agauccccgg cggccucguc      840

gaccgcauga ccgagauccg cggcuucaac gaggaggaga ucaaggucug ccucgagcag      900

auguuccccg aggaccaggc ccuccucggc uggaugcucu cccaggucca ggccgaccgc      960

gcccucuacc ucaugugcac cguccccgcc uucugccgcc ucaccggcau ggcccucggc     1020

caccucuggc gcucccgcac cggcccccag gacgccgagc ucuggccccc ccgcacccuc     1080

ugcgagcucu acuccuggua cuuccgcaug gcccucuccg gcgagggcca ggagaagggc     1140

aaggccuccc cccgcaucga gcaggucgcc cacggcggcc gcaagauggu cggcacccuc     1200

ggccgccucg ccuuccacgg ccuccucaag aagaaguacg ucuucuacga gcaggacaug     1260

aaggccuucg gcgucgaccu cgcccuccuc cagggcgccc ccugcuccug cuuccuccag     1320

cgcgaggaga cccucgccuc cuccgucgcc uacugcuuca cccaccucuc ccuccaggag     1380

uucgucgccg ccgccuacua cuacggcgcc ucccgccgcg ccaucuucga ccucuucacc     1440

gaguccggcg ucuccuggcc ccgccucggc uuccucaccc acuuccgcuc cgccgcccag     1500

cgcgccaugc aggccgagga cggccgccuc gacgucuucc uccgcuuccu cuccggccuc     1560

cucucccccc gcgucaacgc ccuccucgcc ggcucccucc ucgcccaggg cgagcaccag     1620

gccuaccgca cccaggucgc cgagcuccuc cagggcugcc uccgccccga cgccgccguc     1680

ugcgcccgcg ccaucaacgu ccuccacugc cuccacgagc uccagcacac cgagcucgcc     1740

cgcuccgucg aggaggccau ggaguccggc gcccucgccc gccucaccgg ccccgcccac     1800

cgcgccgccc ucgccuaccu ccuccagguc uccgacgccu gcgcccagga ggccaaccuc     1860

ucccucuccc ucucccaggg cguccuccag ucccuccucc cccagcuccu cuacugccgc     1920

aagcuccgcc ucgacaccaa ccaguuccag gaccccguca uggagcuccu cggcuccguc     1980

cucuccggca aggacugccg cauccagaag aucucccucg ccgagaacca gaucuccaac     2040

aagggcgcca aggcccucgc ccgcucccuc cucgucaacc gcucccucac cucccucgac     2100

cuccgcggca acuccaucgg cccccagggc gccaaggccc ucgccgacgc ccucaagauc     2160

aaccgcaccc ucaccucccu cucccuccag ggcaacaccg uccgcgacga cggcgcccgc     2220

uccauggccg aggcccucgc cuccaaccgc acccucucca ugcuccaccu ccagaagaac     2280

uccaucggcc ccaugggcgc ccagcgcaug gccgacgccc ucaagcagaa ccgcucccuc     2340

aaggagcuca uguucuccuc caacuccauc ggcgacggcg gcgccaaggc ccucgccgag     2400

gcccucaagg ucaaccaggg ccucgagucc cucgaccucc aguccaacuc caucuccgac     2460

gccggcgucg ccgcccucau gggcgcccuc ugcaccaacc agacccuccu cucccucucc     2520

cuccgcgaga acuccaucuc ccccgagggc gcccaggcca ucgcccacgc ccucugcgcc     2580

aacuccaccc ucaagaaccu cgaccucacc gccaaccucc uccacgacca gggcgcccgc     2640

gccaucgccg ucgccguccg cgagaaccgc acccucaccu cccuccaccu ccaguggaac     2700

uucauccagg ccggcgccgc ccaggcccuc ggccaggccc uccagcucaa ccgcucccuc     2760

accucccucg accuccagga gaacgccauc ggcgacgacg gcgccugcgc cgucgcccgc     2820

gcccucaagg ucaacaccgc ccucaccgcc cucuaccucc aggucgccuc caucggcgcc     2880

uccggcgccc agguccucgg cgaggcccuc gccgucaacc gcacccucga gauccucgac     2940

cuccgcggca acgccaucgg cgucgccggc gccaaggccc ucgccaacgc ccucaagguc     3000

aacuccuccc uccgccgccu caaccuccag gagaacuccc ucggcaugga cggcgccauc     3060

ugcaucgcca ccgcccucuc cggcaaccac cgccuccagc acaucaaccu ccagggcaac     3120

cacaucggcg acuccggcgc ccgcaugauc uccgaggcca ucaagaccaa cgcccccacc     3180

ugcaccgucg agauguga                                                   3198


<210>  9169
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD3__Homo_sapiens__ACP40993

<400>  9169
augagaaagc aggaggugag gaccggccgg gaagccgggc aaggacacgg uacaggcagc       60

cccgcugagc aggucaaagc acugauggac cuccuugccg ggaagggauc ccagggcucu      120

caggcgccuc aagcucugga ucgcacucca gacgccccgu ugggucccug cucaaacgau      180

agucgaaucc agcgucauag aaaagcauua cugagcaagg uugggggagg cccugaacua      240

ggcgggccau ggcacaggcu cgccucccug cuucuggugg agggauugac ggaccuccag      300

cugcgggaac augauuucac ccagguagag gcuacacgcg guggcgggca ccccgcaaga      360

acuguggccc uggacaggcu cuuuuuaccu cugucucggg ucucggugcc accccgcguu      420

ucaauuacca uaggaguggc uggcaugggu aaaacaaccc uuguccgaca uuucgugaga      480

uugugggccc acgggcaagu aggaaaggau uuuagccugg uucuaccucu cacuuucagg      540

gaccugaaua cacacgagaa acuuugugcg gaucggcuga ucugcagugu guuuccacau      600

gucggcgaac cguccuuggc aguggccgug cccgcucgug cccuccugau uuuagacggc      660

cuggaugagu gucgcacccc ucucgacuuc ucuaacacgg ucgcaugcac ugaucccaaa      720

aaggaaaucc caguugacca ccuuauuacc aauaucauaa gagggaaccu guuuccugag      780

gugagcaucu ggauuacauc caggccauca gcuaguggac agauccccgg uggcuuggua      840

gaccggauga cugagauucg aggguucaau gaagaggaaa ucaaagugug ucuagagcag      900

auguuuccgg aagaucaggc ccugcucgga uggaugcuga gccaagucca ggcggaccgc      960

gcccuuuacc ugaugugcac cgugccugca uucuguagau ugacaggcau ggcucucggu     1020

caucugugga ggucucggac cgggccccag gaugccgagu uauggccacc ucgcacgcug     1080

ugcgagcuau auuccuggua cuuuagaaug gcucucucag gcgaaggaca agagaagggc     1140

aaagccagcc ccaggauaga acagguugca cacgggggac guaagauggu ggguacucug     1200

ggccggcuug ccuuccacgg guugcugaag aaaaaguaug ucuuuuacga gcaggacaug     1260

aaggcuuucg gaguggaucu cgcgcugcuu cagggcgcac cauguaguug cuuccugcaa     1320

cgagaagaga cauuggccuc uuccguagcu uauuguuuua cccaucucag ccugcaggag     1380

uucguugccg cagccuacua uuacggugcu ucgagaaggg ccauuuuuga cuuauucacu     1440

gaaucugggg uguccuggcc ccgccugggc uuucuaacac acuuccgguc agcagcgcag     1500

agagcuaugc aggccgagga uggaaggcuc gacgucuuuc ugcgcuuccu uaguggcuug     1560

cugagcccuc gagugaacgc acuccuggcc ggguccuuac uggcucaagg agaacaucag     1620

gccuaccgga cccaggucgc agagcuuuug caggguugcc uccguccaga ugcugccgug     1680

ugcgcgagag ccaucaaugu ucugcacugu cuacaugaac ugcaacacac ggagcucgcu     1740

aggucugugg aggaagcaau ggagagcggc gcccuggcuc gccuuaccgg gccggcccac     1800

cgggcagcgu uggccuaucu guuacaggua ucagacgcuu gcgcccagga agcaaaccuc     1860

agucuguccc uuagccaggg aguccugcaa ucuuugcucc cccagcugcu auacuguaga     1920

aagcugaggc ucgauacaaa ucaguuucaa gacccuguga uggagcugcu uggcucaguu     1980

uugaguggua aagacugccg cauucagaag aucagccugg cugagaacca gaucuccaau     2040

aaaggggcca aggcauuagc ccgaucucuc cuggugaacc ggucgcuuac uagccuggau     2100

cuaagaggca auuccauugg accacagggc gcuaaggcgc ucgccgacgc acugaaaaua     2160

aacaggaccu ugacaucacu gaguuuacaa gggaauacug uccgugauga cggagcucgc     2220

ucuauggccg aagcccucgc uagcaaccgg acccugucca ugcuucaucu gcagaagaac     2280

ucaaucggcc ccaugggugc acagagaaug gccgaugcgu ugaaacagaa uaggagccuc     2340

aaggagcuga uguucucuuc caacaguauu ggggacggag gcgcuaaagc ccuagcagaa     2400

gcccugaagg ugaaucaagg ucuugagagc cucgaucugc agucuaacuc caucucagac     2460

gcuggcguag cagccuugau gggggcgcug uguacaaauc agaccuuacu cagucugagc     2520

cuucgagaaa acucgauauc cccugaggga gcucaggcca uugcacacgc ccugugcgcu     2580

aauucuacuu ugaagaaccu cgaucugacg gccaaucuac ugcaugacca aggcgcacgg     2640

gcuaucgccg uggcgguucg cgagaacaga acacuuacca gccuccaucu gcaguggaau     2700

uuuauccagg ccggggcagc ucaagccuug ggacaggcuu uacagcugaa caggucacuc     2760

acuucacugg aucuucagga aaaugcaauu ggcgacgaug gugccugugc cgucgcucgg     2820

gcgcugaaag ugaacaccgc auugacagcc cuauaucugc aaguggcuuc caucggggcc     2880

ucuggagcac agguccucgg cgaggcccug gcuguuaauc gaacccuuga aauuuuagac     2940

cugagaggua acgcgauagg cguggccggg gcaaaggcuc ucgccaacgc auugaaagug     3000

aauagcuccc ugcgcaggcu caaccugcag gagaauaguc uuggaaugga cggcgccauc     3060

ugcauugcua cugcccugag cgggaaccac cguuugcagc acaucaaucu acaaggaaac     3120

cacaucggcg auaguggugc gcggaugauu ucugaagcaa uaaagacaaa ugccccaacg     3180

uguaccguag agauguga                                                   3198


<210>  9170
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD3__Homo_sapiens__ACP40993

<400>  9170
augagaaagc aggaggugag aaccggcaga gaggccggcc agggccacgg caccggcagc       60

cccgccgagc aggugaaggc ccugauggac cugcuggccg gcaagggcag ccagggcagc      120

caggcccccc aggcccugga cagaaccccc gacgcccccc ugggccccug cagcaacgac      180

agcagaaucc agagacacag aaaggcccug cugagcaagg ugggcggcgg ccccgagcug      240

ggcggccccu ggcacagacu ggccagccug cugcuggugg agggccugac cgaccugcag      300

cugagagagc acgacuucac ccagguggag gccaccagag gcggcggcca ccccgccaga      360

accguggccc uggacagacu guuccugccc cugagcagag ugagcgugcc ccccagagug      420

agcaucacca ucggcguggc cggcaugggc aagaccaccc uggugagaca cuucgugaga      480

cugugggccc acggccaggu gggcaaggac uucagccugg ugcugccccu gaccuucaga      540

gaccugaaca cccacgagaa gcugugcgcc gacagacuga ucugcagcgu guucccccac      600

gugggcgagc ccagccuggc cguggccgug cccgccagag cccugcugau ccuggacggc      660

cuggacgagu gcagaacccc ccuggacuuc agcaacaccg uggccugcac cgaccccaag      720

aaggagaucc ccguggacca ccugaucacc aacaucauca gaggcaaccu guuccccgag      780

gugagcaucu ggaucaccag cagacccagc gccagcggcc agauccccgg cggccuggug      840

gacagaauga ccgagaucag aggcuucaac gaggaggaga ucaaggugug ccuggagcag      900

auguuccccg aggaccaggc ccugcugggc uggaugcuga gccaggugca ggccgacaga      960

gcccuguacc ugaugugcac cgugcccgcc uucugcagac ugaccggcau ggcccugggc     1020

caccugugga gaagcagaac cggcccccag gacgccgagc uguggccccc cagaacccug     1080

ugcgagcugu acagcuggua cuucagaaug gcccugagcg gcgagggcca ggagaagggc     1140

aaggccagcc ccagaaucga gcagguggcc cacggcggca gaaagauggu gggcacccug     1200

ggcagacugg ccuuccacgg ccugcugaag aagaaguacg uguucuacga gcaggacaug     1260

aaggccuucg gcguggaccu ggcccugcug cagggcgccc ccugcagcug cuuccugcag     1320

agagaggaga cccuggccag cagcguggcc uacugcuuca cccaccugag ccugcaggag     1380

uucguggccg ccgccuacua cuacggcgcc agcagaagag ccaucuucga ccuguucacc     1440

gagagcggcg ugagcuggcc cagacugggc uuccugaccc acuucagaag cgccgcccag     1500

agagccaugc aggccgagga cggcagacug gacguguucc ugagauuccu gagcggccug     1560

cugagcccca gagugaacgc ccugcuggcc ggcagccugc uggcccaggg cgagcaccag     1620

gccuacagaa cccagguggc cgagcugcug cagggcugcc ugagacccga cgccgccgug     1680

ugcgccagag ccaucaacgu gcugcacugc cugcacgagc ugcagcacac cgagcuggcc     1740

agaagcgugg aggaggccau ggagagcggc gcccuggcca gacugaccgg ccccgcccac     1800

agagccgccc uggccuaccu gcugcaggug agcgacgccu gcgcccagga ggccaaccug     1860

agccugagcc ugagccaggg cgugcugcag agccugcugc cccagcugcu guacugcaga     1920

aagcugagac uggacaccaa ccaguuccag gaccccguga uggagcugcu gggcagcgug     1980

cugagcggca aggacugcag aauccagaag aucagccugg ccgagaacca gaucagcaac     2040

aagggcgcca aggcccuggc cagaagccug cuggugaaca gaagccugac cagccuggac     2100

cugagaggca acagcaucgg cccccagggc gccaaggccc uggccgacgc ccugaagauc     2160

aacagaaccc ugaccagccu gagccugcag ggcaacaccg ugagagacga cggcgccaga     2220

agcauggccg aggcccuggc cagcaacaga acccugagca ugcugcaccu gcagaagaac     2280

agcaucggcc ccaugggcgc ccagagaaug gccgacgccc ugaagcagaa cagaagccug     2340

aaggagcuga uguucagcag caacagcauc ggcgacggcg gcgccaaggc ccuggccgag     2400

gcccugaagg ugaaccaggg ccuggagagc cuggaccugc agagcaacag caucagcgac     2460

gccggcgugg ccgcccugau gggcgcccug ugcaccaacc agacccugcu gagccugagc     2520

cugagagaga acagcaucag ccccgagggc gcccaggcca ucgcccacgc ccugugcgcc     2580

aacagcaccc ugaagaaccu ggaccugacc gccaaccugc ugcacgacca gggcgccaga     2640

gccaucgccg uggccgugag agagaacaga acccugacca gccugcaccu gcaguggaac     2700

uucauccagg ccggcgccgc ccaggcccug ggccaggccc ugcagcugaa cagaagccug     2760

accagccugg accugcagga gaacgccauc ggcgacgacg gcgccugcgc cguggccaga     2820

gcccugaagg ugaacaccgc ccugaccgcc cuguaccugc agguggccag caucggcgcc     2880

agcggcgccc aggugcuggg cgaggcccug gccgugaaca gaacccugga gauccuggac     2940

cugagaggca acgccaucgg cguggccggc gccaaggccc uggccaacgc ccugaaggug     3000

aacagcagcc ugagaagacu gaaccugcag gagaacagcc ugggcaugga cggcgccauc     3060

ugcaucgcca ccgcccugag cggcaaccac agacugcagc acaucaaccu gcagggcaac     3120

cacaucggcg acagcggcgc cagaaugauc agcgaggcca ucaagaccaa cgcccccacc     3180

ugcaccgugg agauguga                                                   3198


<210>  9171
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD3__Homo_sapiens__ACP40993

<400>  9171
augagaaagc aggaggugcg gaccggccgc gaagccgggc aaggacacgg cacagggagc       60

cccgcugagc aggucaaagc ccugauggac cuccuggcgg gaaagggcuc ccaggggucu      120

caggcuccuc aagcccuuga uagaacgccg gacgcucccc ugggaccuug cagcaacgau      180

ucccggaucc agcgccauag aaaagcccuc cugucuaagg uuggcggcgg gcccgaacuu      240

ggaggcccuu ggcaccggcu ggccagccuc cugcuggugg aggggcucac cgaccugcag      300

cuucgcgaac augauuucac acagguggag gcuaccagag gaggcgggca ccccgcccgg      360

acagucgcgc uggaccgccu cuuucugccu cuuuccagag ugucuguucc gccccgggug      420

agcauuacca ucggagucgc cggcaugggc aaaacaaccc uggugcgcca uuucguuaga      480

cucugggcuc acgggcaagu gggaaaggau uuuucccugg uccugccucu cacguuccgg      540

gaccugaaua cccacgagaa acuuugugcc gaucgccuga uuugcagcgu guuuccccau      600

gugggcgaac cuucucucgc ugucgccguu cccgcgagag cccugcuuau ccuggacggg      660

cucgaugagu gucggacacc gcuggacuuc uccaacaccg uggcuugcac agauccuaag      720

aaggaaauuc ccguggacca ccugaucacc aauaucauua gaggaaaccu cuuuccugag      780

gucagcaucu ggauuacguc ucgccccucc gccagcggcc agauccccgg gggacuggug      840

gaccggauga cagagauuag aggcuucaau gaagaggaaa ucaaaguuug ucuugagcag      900

auguuuccug aagaucaggc ucugcucggc uggaugcugu cucaagugca ggccgaccgc      960

gcccuuuacc ugaugugcac cgucccggcu uucugucggc ucacagggau ggcgcuggga     1020

caucugugga gaucccgcac cggcccccag gaugccgagc ucuggccucc ccggacccug     1080

ugcgagcuuu auagcuggua cuuuagaaug gcucuguccg gggaaggaca agagaagggc     1140

aaagccucuc cucgcauuga acagguggcc cacgggggcc ggaagauggu uggaacacuc     1200

ggcagacugg cuuuccacgg gcugcuuaag aaaaaguaug uguuuuacga gcaggacaug     1260

aaagccuucg gagucgaucu cgcgcugcug cagggcgcuc ccuguagcug cuuccuccaa     1320

cgcgaagaga cgcuggccuc cagcguggcc uauuguuuua cccaucuuuc ucugcaggag     1380

uucgucgcug ccgcuuacua uuacggggcc ucccggagag cgaucuuuga ccucuucaca     1440

gaaagcggag ugucuuggcc gcggcugggc uuucugaccc acuuccgcag cgccgcucag     1500

agagccaugc aggcugagga ugggcggcuu gacguuuuuc ucagauuccu guccggccug     1560

cucucuccuc gcgugaacgc ccugcuugcg ggaagccugc ucgcccaagg cgaacaucag     1620

gcuuaccgga cacaggucgc cgagcugcug caggggugcc uuagacccga ugcugccgug     1680

ugcgcccgcg cuaucaaugu ucuccacugu cugcaugaac ugcaacacac cgagcucgcg     1740

agauccgugg aggaagccau ggagagcgga gcucuggccc ggcuuacggg cccugcccac     1800

cgcgcugccc uggcguaucu ccugcagguc ucugacgcuu gcgcccagga agccaaccug     1860

ucccuuagcc ucucucaggg ggugcugcaa ucccugcucc cccagcugcu uuacuguaga     1920

aagcugcggc ucgauacaaa ucaguuucaa gacccuguga uggagcugcu gggaagcguu     1980

cuuuccggca aagacugccg cauucagaag aucucucugg cugagaacca gauuagcaau     2040

aaaggggcca aggcgcucgc uagaucccug cucgucaacc ggucucugac cagccuugau     2100

cugcgcggca auuccaucgg accccagggc gccaaggccc ucgcugacgc ccugaaaauu     2160

aacagaaccc ugacaagccu uucucugcaa gggaauaccg ugcgggauga cggagcucgc     2220

uccauggccg aagcgcucgc cagcaacaga acacugucua ugcuccaucu gcagaagaac     2280

uccaucggcc cgaugggggc ucagcggaug gccgaugcuc uuaaacagaa uagaagccug     2340

aaggagcuca uguucucuag caacuccauc ggagacggcg gggccaaagc ccuggcugaa     2400

gcgcugaagg ugaaucaagg ccuugagagc cuggaucucc agucuaacuc cauuagcgac     2460

gccggagucg cugcccugau gggcgcccuc uguacgaauc agacccugcu uucccugucu     2520

cugcgcgaaa acagcaucuc cccugagggg gcucaggcca uugcgcacgc ucucugcgcc     2580

aauucuacac ugaagaaccu ugaucugacc gccaaucucc ugcaugacca aggagcucgg     2640

gccaucgcgg uggcuguuag agagaaccgc acacucacca gccugcaccu ucaguggaau     2700

uuuauucagg ccggcgccgc ucaagcccug gggcaggcuc ugcagcucaa ccggucccug     2760

acgucucuug aucugcagga aaaugccauc ggagacgaug gcgcgugugc cguggcuaga     2820

gcccucaaag ucaacaccgc ucugacagcc cucuaucugc aaguggccag caucggcgcu     2880

uccggggcgc agguucuugg agaggcccug gcugugaauc gcacccugga aauucucgac     2940

cugcggggca acgccaucgg ggucgccgga gcuaaggccc uugcgaacgc ucugaaagug     3000

aauagcucuc ucagacgccu gaaccuccag gaaaauuccc ugggcaugga cggggccauu     3060

ugcaucgcca cagcucuuag cggaaaccac cggcugcagc auauuaaucu gcaaggcaac     3120

cacaucggcg auucuggggc cagaaugauu uccgaggcga ucaagaccaa ugcccccacg     3180

uguacaguug agauguga                                                   3198


<210>  9172
<211>  1112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__H3BLT9

<400>  9172

Met Glu Met Asp Ala Pro Arg Pro Pro Ser Leu Ala Val Pro Gly Ala 
1               5                   10                  15      


Ala Ser Arg Pro Gly Arg Leu Leu Asp Gly Gly His Gly Arg Gln Gln 
            20                  25                  30          


Val Gln Ala Leu Ser Ser Gln Leu Leu Glu Val Ile Pro Asp Ser Met 
        35                  40                  45              


Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His Gly 
    50                  55                  60                  


Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu Ala 
65                  70                  75                  80  


Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg Thr 
                85                  90                  95      


Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln Arg 
            100                 105                 110         


His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu Gly 
        115                 120                 125             


Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu Thr 
    130                 135                 140                 


Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr Arg 
145                 150                 155                 160 


Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe Leu 
                165                 170                 175     


Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile Gly 
            180                 185                 190         


Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg Leu 
        195                 200                 205             


Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro Leu 
    210                 215                 220                 


Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg Leu 
225                 230                 235                 240 


Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val Ala 
                245                 250                 255     


Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys Arg 
            260                 265                 270         


Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys Lys 
        275                 280                 285             


Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn Leu 
    290                 295                 300                 


Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser Gly 
305                 310                 315                 320 


Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly Phe 
                325                 330                 335     


Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu Asp 
            340                 345                 350         


Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg Ala 
        355                 360                 365             


Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly Met 
    370                 375                 380                 


Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala Glu 
385                 390                 395                 400 


Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe Arg 
                405                 410                 415     


Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro Arg 
            420                 425                 430         


Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu Gly 
        435                 440                 445             


Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr Glu 
    450                 455                 460                 


Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly Ala 
465                 470                 475                 480 


Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser Val 
                485                 490                 495     


Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala Ala 
            500                 505                 510         


Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr Glu 
        515                 520                 525             


Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg Ser 
    530                 535                 540                 


Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val Phe 
545                 550                 555                 560 


Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu Leu 
                565                 570                 575     


Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr Gln 
            580                 585                 590         


Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val Cys 
        595                 600                 605             


Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His Thr 
    610                 615                 620                 


Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu Ala 
625                 630                 635                 640 


Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu Gln 
                645                 650                 655     


Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu Ser 
            660                 665                 670         


Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg Lys 
        675                 680                 685             


Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu Leu 
    690                 695                 700                 


Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser Leu 
705                 710                 715                 720 


Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg Ser 
                725                 730                 735     


Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn Ser 
            740                 745                 750         


Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile Asn 
        755                 760                 765             


Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp Asp 
    770                 775                 780                 


Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu Ser 
785                 790                 795                 800 


Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln Arg 
                805                 810                 815     


Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met Phe 
            820                 825                 830         


Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu Ala 
        835                 840                 845             


Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn Ser 
    850                 855                 860                 


Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr Asn 
865                 870                 875                 880 


Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro Glu 
                885                 890                 895     


Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu Lys 
            900                 905                 910         


Asn Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg Ala 
        915                 920                 925             


Ile Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His Leu 
    930                 935                 940                 


Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln Ala 
945                 950                 955                 960 


Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn Ala 
                965                 970                 975     


Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val Asn 
            980                 985                 990         


Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser Ile Gly Ala Ser 
        995                 1000                1005            


Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn Arg Thr Leu Glu 
    1010                1015                1020                


Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala Gly Ala Lys Ala 
1025                1030                1035                1040


Leu Ala Asn Ala Leu Lys Val Asn Ser Ser Leu Arg Arg Leu Asn Leu 
                1045                1050                1055    


Gln Glu Asn Ser Leu Gly Met Asp Gly Ala Ile Cys Ile Ala Thr Ala 
            1060                1065                1070        


Leu Ser Gly Asn His Arg Leu Gln His Ile Asn Leu Gln Gly Asn His 
        1075                1080                1085            


Ile Gly Asp Ser Gly Ala Arg Met Ile Ser Glu Ala Ile Lys Thr Asn 
    1090                1095                1100                


Ala Pro Thr Cys Thr Val Glu Met 
1105                1110        


<210>  9173
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__EAW85351

<400>  9173
auggagaugg acgcccccag gccccccagu cuugcugucc cuggagcagc aucgaggccc       60

gggaggcugc uggauggggg gcacggcagg cagcagguuc aggcccucuc uucacagcuc      120

cuggagguga uccccgacuc caugaggaag caagaggugc ggacgggcag ggaggccggc      180

cagggccacg guacgggcuc cccagccgag caggugaaag cccucaugga ucugcuggcu      240

gggaagggca gucaaggcuc ccaggccccg caggcccugg auaggacacc ggaugccccg      300

cuggggcccu gcagcaauga cucaaggaua cagaggcacc gcaaggcccu gcugagcaag      360

gugggaggug gcccggagcu gggcggaccc uggcacaggc uggccucccu ccugcuggug      420

gagggccuga cggaccugca gcugagggaa cacgacuuca cacaggugga ggccacccgc      480

gggggcgggc accccgccag gaccgucgcc cuggaccggc ucuuccugcc ucucucccgg      540

gugucugucc caccccgggu cuccaucacu aucggggugg ccggcauggg caagaccacc      600

cuggugaggc acuucguccg ccucugggcc caugggcagg ucggcaagga cuucucgcug      660

gugcugccuc ugaccuuccg ggaucucaac acccacgaga agcugugugc cgaccgacuc      720

aucugcucgg ucuucccgca cgucggggag cccagccugg cgguggcagu cccagccagg      780

gcccuccuga uccuggacgg cuuggaugag ugcaggacgc cucuggacuu cuccaacacc      840

guggccugca cggacccaaa gaaggagauc ccgguggacc accugaucac caacaucauc      900

cguggcaacc ucuuuccgga aguuuccauc uggaucaccu cccgucccag ugcaucuggc      960

cagaucccag ggggccuggu ggaccggaug acggagaucc ggggcuuuaa cgaggaggag     1020

aucaaggugu guuuggagca gauguucccc gaggaccagg cccuucuggg cuggaugcug     1080

agccaagugc aggcugacag ggcccuguac cugaugugca ccgucccagc cuucugcagg     1140

cucacgggga uggcgcuagg ccaccugugg cgcagcagga cggggcccca ggaugcagag     1200

cuguggcccc cgaggacccu gugcgagcuc uacucauggu acuuuaggau ggcccucagc     1260

ggggaggggc aggagaaggg caaggcaagc ccucgcaucg agcagguggc ccaugguggc     1320

cgcaagaugg uggggacauu gggccgucug gccuuccaug ggcugcucaa gaagaaauac     1380

guguuuuacg agcaagacau gaaggcguuu gguguagacc ucgcucugcu gcagggcgcc     1440

ccgugcagcu gcuuccugca gagagaggag acguuggcau cgucaguggc cuacugcuuc     1500

acccaccugu cccugcagga guuuguggca gccgcguauu acuauggcgc auccaggagg     1560

gccaucuucg accucuucac ugagagcggc guauccuggc ccaggcuggg cuuccucacg     1620

cauuucagga gcgcagccca gcgggccaug caggcagagg acgggaggcu ggacguguuc     1680

cugcgcuucc ucuccggccu cuugucuccg agggucaaug cccuccuggc cggcucccug     1740

cuggcccaag gcgagcacca ggccuaccgg acccaggugg cugagcuccu gcagggcugc     1800

cugcgccccg augccgcagu cugugcacgg gccaucaacg uguugcacug ccugcaugag     1860

cugcagcaca ccgagcuggc ccgcagcgug gaggaggcca uggagagcgg ggcccuggcc     1920

aggcugacug gucccgcgca ccgcgcugcc cuggccuacc uccugcaggu guccgacgcc     1980

ugugcccagg aggccaaccu gucccugagc cucagccagg gcguccuuca gagccugcug     2040

ccccagcugc ucuacugccg gaagcucagg cuggacacca accaguucca ggaccccgug     2100

auggagcugc ugggcagcgu gcugaguggg aaggacuguc gcauucagaa gaucagcuug     2160

gcggagaacc agaucaguaa caaaggggcc aaagcucugg ccagaucccu cuuggucaac     2220

agaagucuga ccucucugga ccuccgcggu aacuccauug gaccacaagg ggccaaggcg     2280

cuggcagacg cuuugaagau caaccgcacc cugaccuccc ugagccucca gggcaacacc     2340

guuagggaug auggugccag guccauggcu gaggccuugg ccuccaaccg gacccucucc     2400

augcugcacc ugcagaagaa cagcaucggg cccaugggag cccagcggau ggcagaugcc     2460

uugaagcaga acaggagucu gaaagagcuc auguucucca guaauaguau uggugaugga     2520

ggugccaagg cccuggcuga ggcccugaag gugaaccagg gccuggagag ccuggaccug     2580

cagagcaauu ccaucaguga cgcaggagug gcagcacuga ugggggcccu cugcaccaac     2640

cagacccucc ucagccucag ccuucgagaa aacuccauca gucccgaggg agcccaggcc     2700

aucgcucaug cccucugcgc caacagcacc cugaagaacc uggaccugac agccaaccuc     2760

cuccacgacc agggugcccg ggccaucgca guggcaguga gagaaaaccg cacccucacc     2820

ucccuucacc ugcaguggaa cuucauccag gccggcgcug cccaggcccu gggacaagca     2880

cuacagcuca acaggagccu caccagcuua gauuuacagg agaacgccau cggggaugac     2940

ggagcgugug cgguggcccg ugcacugaag gucaacacag cccucacugc ucucuaucuc     3000

cagguggccu caauuggugc uucaggcgcc caggugcuag gggaagccuu ggcugugaac     3060

agaaccuugg agauucucga cuuaagagga aaugccauug ggguggcugg agccaaagcc     3120

cuggcaaaug cucugaaggu aaacucaagu cuccggagac ucaaucuuca agagaauucu     3180

cuggggaugg acggggcgau augcauugcc acagcacugu cuggaaacca caggcuccag     3240

cauaucaauc uccagggaaa ccacauuggg gacuccgggg ccaggaugau cucagaggcc     3300

aucaagacaa augcucccac gugcacuguu gaaauguga                            3339


<210>  9174
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD3__Homo_sapiens__EAW85351

<400>  9174
auggagaugg acgcgccccg cccgcccagc cuggccgugc ccggcgccgc cucccggccc       60

gggcgccucc uggacggcgg gcacggccgg cagcaggucc aggcccugag cucccagcuc      120

cuggagguga ucccggacag caugcgcaag caggaggugc ggaccgggcg cgaggccggc      180

cagggccacg ggaccggcuc ccccgccgag caggucaagg cgcugaugga ccuccuggcc      240

gggaagggca gccagggguc ccaggcgccc caggcccugg accggacccc cgacgccccg      300

cucggccccu gcagcaacga cucccgcauc cagcggcacc gcaaggcccu gcugagcaag      360

gugggcgggg gccccgagcu cgggggcccc uggcaccggc uggccucccu gcuccuggug      420

gagggccuga ccgaccucca gcugcgcgag cacgacuuca cccaggucga ggccacccgc      480

gggggcgggc acccggcccg gacgguggcg cuggaccggc uguuccugcc ccugagccgc      540

guguccgucc cgccccgggu gagcaucacc aucggcgugg ccgggauggg caagaccacc      600

cucguccgcc acuucgugcg gcugugggcc cacggccagg uggggaagga cuucucccug      660

guccuccccc ugacguuccg cgaccugaac acccacgaga agcucugcgc cgaccggcug      720

aucugcagcg uguuccccca cgugggcgag cccucccugg ccgucgcggu gcccgcccgc      780

gcccuccuga uccuggacgg gcucgacgag ugccgcaccc cgcuggacuu cagcaacacc      840

guggccugca cggaccccaa gaaggagauc cccgucgacc accugaucac caacaucauc      900

cggggcaacc ucuuccccga gguguccauc uggaucacca gccgcccgag cgccuccggg      960

cagauccccg gcggccuggu ggaccggaug accgagaucc gcggguucaa cgaggaggag     1020

aucaaggucu gccuggagca gauguucccc gaggaccagg cgcuccuggg cuggaugcug     1080

agccaggugc aggccgaccg ggcccucuac cugaugugca cgguccccgc cuucugccgc     1140

cugaccggga uggcccucgg ccaccugugg cggucccgca ccgggccgca ggacgcggag     1200

cuguggccgc cccggacccu gugcgagcuc uacagcuggu acuuccgcau ggcccugucc     1260

ggcgagggcc aggagaaggg gaaggccagc ccccggaucg agcaggucgc ccacggcggg     1320

cgcaagaugg ugggcacgcu gggccggcuc gcguuccacg ggcugcugaa gaagaaguac     1380

guguucuacg agcaggacau gaaggccuuc ggcguggacc ucgcccugcu gcagggggcc     1440

cccugcuccu gcuuccucca gcgcgaggag acccuggcca gcuccguggc guacugcuuc     1500

acccaccuga gccuccagga guucgucgcc gccgccuacu acuacggcgc cucccggcgc     1560

gcgaucuucg accuguucac cgagagcggg guguccuggc cccggcuggg cuuccucacg     1620

cacuuccgca gcgccgccca gcgggccaug caggccgagg acggccgccu ggacguguuc     1680

cugcgcuucc ucuccgggcu gcugagcccc cgggucaacg cgcuccuggc cggcucccug     1740

cucgcccagg gggagcacca ggccuaccgc acccaggugg cggagcugcu gcagggcugc     1800

cuccggccgg acgccgccgu gugcgcccgc gccaucaacg uccugcacug ccugcacgag     1860

cuccagcaca ccgagcuggc gcggagcgug gaggaggcca uggaguccgg ggcccuggcc     1920

cgccucaccg gccccgccca ccgggcggcc cuggccuacc ugcuccaggu gagcgacgcc     1980

ugcgcccagg aggcgaaccu gagccugucc cucagccagg gcguccugca gucccugcuc     2040

ccccagcugc uguacugccg caagcuccgg cuggacacga accaguucca ggaccccgug     2100

auggagcugc ucgggagcgu gcuguccggc aaggacugcc gcauccagaa gaucagccug     2160

gccgagaacc agaucuccaa caagggggcc aaggcccucg cgcggagccu gcuggucaac     2220

cgcucccuca ccagccugga ccugcggggc aacuccaucg ggccgcaggg cgccaaggcc     2280

cucgccgacg cccugaagau caaccgcacc cugaccagcc ucucccugca gggcaacacg     2340

gugcgggacg acggggcgcg cagcauggcc gaggcccugg ccuccaaccg gacccucagc     2400

augcugcacc uccagaagaa cuccaucggc cccauggggg cccagcgcau ggcggacgcc     2460

cucaagcaga accggagccu gaaggagcug auguucagcu ccaacagcau cggcgacggg     2520

ggcgccaagg cccucgccga ggcgcugaag gugaaccagg gccuggaguc ccucgaccug     2580

cagagcaacu ccaucagcga cgccgggguc gccgcccuga ugggcgcccu cugcaccaac     2640

cagacccugc ugucccucag ccugcgcgag aacuccauca gccccgaggg ggcgcaggcc     2700

aucgcccacg cccugugcgc gaacuccacg cucaagaacc uggaccugac cgccaaccuc     2760

cugcacgacc agggcgcccg ggccaucgcc guggcggugc gcgagaaccg cacccugacc     2820

agccuccacc uccaguggaa cuucauccag gccggcgccg cccaggcccu ggggcaggcg     2880

cugcagcuga accggucccu gaccagccuc gaccugcagg agaacgccau cggcgacgac     2940

ggggccugcg ccgucgcccg cgcgcugaag gugaacacgg cccugaccgc ccucuaccuc     3000

cagguggccu ccaucggcgc gagcggggcc cagguccugg gcgaggcccu ggccgugaac     3060

cggacccugg agauccugga ccuccgcggc aacgccaucg ggguggcggg cgccaaggcc     3120

cuggccaacg cccugaaggu caacuccagc cuccggcgcc ugaaccugca ggagaacucc     3180

cucgggaugg acggcgcgau cugcaucgcc accgcccuga gcgggaacca ccggcugcag     3240

cacaucaacc uccagggcaa ccacaucggc gacagcgggg cccgcaugau cuccgaggcc     3300

aucaagacga acgcgcccac gugcaccgug gagauguga                            3339


<210>  9175
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD3__Homo_sapiens__EAW85351

<400>  9175
auggagaugg acgccccccg cccccccucc cucgccgucc ccggcgccgc cucccgcccc       60

ggccgccucc ucgacggcgg ccacggccgc cagcaggucc aggcccucuc cucccagcuc      120

cucgagguca uccccgacuc caugcgcaag caggaggucc gcaccggccg cgaggccggc      180

cagggccacg gcaccggcuc ccccgccgag caggucaagg cccucaugga ccuccucgcc      240

ggcaagggcu cccagggcuc ccaggccccc caggcccucg accgcacccc cgacgccccc      300

cucggccccu gcuccaacga cucccgcauc cagcgccacc gcaaggcccu ccucuccaag      360

gucggcggcg gccccgagcu cggcggcccc uggcaccgcc ucgccucccu ccuccucguc      420

gagggccuca ccgaccucca gcuccgcgag cacgacuuca cccaggucga ggccacccgc      480

ggcggcggcc accccgcccg caccgucgcc cucgaccgcc ucuuccuccc ccucucccgc      540

gucuccgucc ccccccgcgu cuccaucacc aucggcgucg ccggcauggg caagaccacc      600

cucguccgcc acuucguccg ccucugggcc cacggccagg ucggcaagga cuucucccuc      660

guccuccccc ucaccuuccg cgaccucaac acccacgaga agcucugcgc cgaccgccuc      720

aucugcuccg ucuuccccca cgucggcgag cccucccucg ccgucgccgu ccccgcccgc      780

gcccuccuca uccucgacgg ccucgacgag ugccgcaccc cccucgacuu cuccaacacc      840

gucgccugca ccgaccccaa gaaggagauc cccgucgacc accucaucac caacaucauc      900

cgcggcaacc ucuuccccga ggucuccauc uggaucaccu cccgccccuc cgccuccggc      960

cagauccccg gcggccucgu cgaccgcaug accgagaucc gcggcuucaa cgaggaggag     1020

aucaaggucu gccucgagca gauguucccc gaggaccagg cccuccucgg cuggaugcuc     1080

ucccaggucc aggccgaccg cgcccucuac cucaugugca ccguccccgc cuucugccgc     1140

cucaccggca uggcccucgg ccaccucugg cgcucccgca ccggccccca ggacgccgag     1200

cucuggcccc cccgcacccu cugcgagcuc uacuccuggu acuuccgcau ggcccucucc     1260

ggcgagggcc aggagaaggg caaggccucc ccccgcaucg agcaggucgc ccacggcggc     1320

cgcaagaugg ucggcacccu cggccgccuc gccuuccacg gccuccucaa gaagaaguac     1380

gucuucuacg agcaggacau gaaggccuuc ggcgucgacc ucgcccuccu ccagggcgcc     1440

cccugcuccu gcuuccucca gcgcgaggag acccucgccu ccuccgucgc cuacugcuuc     1500

acccaccucu cccuccagga guucgucgcc gccgccuacu acuacggcgc cucccgccgc     1560

gccaucuucg accucuucac cgaguccggc gucuccuggc cccgccucgg cuuccucacc     1620

cacuuccgcu ccgccgccca gcgcgccaug caggccgagg acggccgccu cgacgucuuc     1680

cuccgcuucc ucuccggccu ccucuccccc cgcgucaacg cccuccucgc cggcucccuc     1740

cucgcccagg gcgagcacca ggccuaccgc acccaggucg ccgagcuccu ccagggcugc     1800

cuccgccccg acgccgccgu cugcgcccgc gccaucaacg uccuccacug ccuccacgag     1860

cuccagcaca ccgagcucgc ccgcuccguc gaggaggcca uggaguccgg cgcccucgcc     1920

cgccucaccg gccccgccca ccgcgccgcc cucgccuacc uccuccaggu cuccgacgcc     1980

ugcgcccagg aggccaaccu cucccucucc cucucccagg gcguccucca gucccuccuc     2040

ccccagcucc ucuacugccg caagcuccgc cucgacacca accaguucca ggaccccguc     2100

auggagcucc ucggcuccgu ccucuccggc aaggacugcc gcauccagaa gaucucccuc     2160

gccgagaacc agaucuccaa caagggcgcc aaggcccucg cccgcucccu ccucgucaac     2220

cgcucccuca ccucccucga ccuccgcggc aacuccaucg gcccccaggg cgccaaggcc     2280

cucgccgacg cccucaagau caaccgcacc cucaccuccc ucucccucca gggcaacacc     2340

guccgcgacg acggcgcccg cuccauggcc gaggcccucg ccuccaaccg cacccucucc     2400

augcuccacc uccagaagaa cuccaucggc cccaugggcg cccagcgcau ggccgacgcc     2460

cucaagcaga accgcucccu caaggagcuc auguucuccu ccaacuccau cggcgacggc     2520

ggcgccaagg cccucgccga ggcccucaag gucaaccagg gccucgaguc ccucgaccuc     2580

caguccaacu ccaucuccga cgccggcguc gccgcccuca ugggcgcccu cugcaccaac     2640

cagacccucc ucucccucuc ccuccgcgag aacuccaucu cccccgaggg cgcccaggcc     2700

aucgcccacg cccucugcgc caacuccacc cucaagaacc ucgaccucac cgccaaccuc     2760

cuccacgacc agggcgcccg cgccaucgcc gucgccgucc gcgagaaccg cacccucacc     2820

ucccuccacc uccaguggaa cuucauccag gccggcgccg cccaggcccu cggccaggcc     2880

cuccagcuca accgcucccu caccucccuc gaccuccagg agaacgccau cggcgacgac     2940

ggcgccugcg ccgucgcccg cgcccucaag gucaacaccg cccucaccgc ccucuaccuc     3000

caggucgccu ccaucggcgc cuccggcgcc cagguccucg gcgaggcccu cgccgucaac     3060

cgcacccucg agauccucga ccuccgcggc aacgccaucg gcgucgccgg cgccaaggcc     3120

cucgccaacg cccucaaggu caacuccucc cuccgccgcc ucaaccucca ggagaacucc     3180

cucggcaugg acggcgccau cugcaucgcc accgcccucu ccggcaacca ccgccuccag     3240

cacaucaacc uccagggcaa ccacaucggc gacuccggcg cccgcaugau cuccgaggcc     3300

aucaagacca acgcccccac cugcaccguc gagauguga                            3339


<210>  9176
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD3__Homo_sapiens__EAW85351

<400>  9176
auggagaugg acgcccccag accuccaagc cuggcugugc cgggcgcagc cuccaggccc       60

gggcggcucc uugauggagg ucacggccgc cagcaagucc aggcgcuguc uucacaguug      120

uuagaaguua ucccugacag uaugcgaaag caggaggugc guaccgggag agaagcugga      180

caaggccaug guacagggag cccagccgag cagguaaaag cacugaugga ucuacucgcc      240

ggaaagggcu cccagggcuc ucaggcuccc caagcacugg acaggacucc ugaugcccca      300

cuugggcccu gcucgaacga cucacggauu cagcgccaca gaaaagcucu guugagcaag      360

gugggaggug gcccugaacu cgggggacca uggcauaggc uggccagucu gcucuuaguc      420

gagggccuga cggaucuuca guugcgggag cacgacuuca cccaggugga agcgacacgc      480

ggugggggac auccggcacg aacuguugcc cuggauagac uauuucuccc ccuguccagg      540

gugucugucc cuccacgggu gagcauaacc aucggcguag cuggcauggg gaaaacaacc      600

cuuguucguc acuucgugcg ccugugggcc cacggacaag ucgguaagga cuuuuccuug      660

gugcuccccc ugacuuucag agauuuaaau acacaugaga agcugugugc agacaggcuc      720

auuugcucag uguuuccuca cgucggcgaa ccaagucuug cuguugccgu gcccgcgcgg      780

gcccuguuga uccuagaugg gcuggacgag ugucgaaccc cgcucgacuu cagcaacacg      840

guagcaugca cugauccuaa aaaggagauu cccguggacc aucugaucac caauauaauc      900

cgcggaaacc uuuuuccaga agucucuauu uggaucacau ccagaccuuc agcuagcggc      960

cagauucccg gugggcuggu ggauaggaug acugagaucc ggggcuucaa ugaagaggaa     1020

auaaaaguuu guuuggagca gauguuucca gaggaccaag cccuccuggg auggauguua     1080

agucaggugc aggcugaucg cgcccuguac cuaaugugca ccguccccgc auucuguaga     1140

cucacaggca uggcccuggg gcaccuuugg aggucucgua ccggaccuca ggacgcugaa     1200

uuguggccac cgcggacgcu gugcgagcuc uauuccuggu acuuucgaau ggcgcugagc     1260

ggugaaggcc aagagaaggg gaaagcaucg cccagaauug aacagguggc ccacggaggc     1320

aggaagaugg uagguacucu ugggcgccug gcuuuccaug gcuugcucaa gaaaaaguau     1380

guguuuuacg agcaggauau gaaagccuuc ggaguggacc uggcauuacu gcagggcgcc     1440

ccuuguucuu gcuuccuaca acgggaggaa acacucgcuu ccucagucgc cuauuguuuu     1500

acccaccuga gucuucagga guucguggca gcggcuuacu auuacggggc cagcagaagg     1560

gcaaucuuug auuuguucac ugaauccgga gucucuuggc cacgccuggg uuuucucaca     1620

cauuuccgaa gcgccgcuca gcgggccaug caggcagagg acggccgucu ggauguguuu     1680

uuaagauucc ugucagggcu uuugaguccc aggguuaacg cucuccuggc cggaucccua     1740

cuggcgcaag gcgaacacca ggccuaccgc acccaggugg cugagcuccu gcaggguugc     1800

cuucggccug acgcagccgu augcgcuaga gccauuaaug ucuugcauug ucugcacgag     1860

uuacaacaca cggaacucgc aaggagcgug gaggaagcga uggagucugg ggcccuggcu     1920

cgacuuaccg gcccagccca ucgcgcagcu cuggccuauu ugcuccaggu uucagacgca     1980

ugcgcccagg aggcuaaccu gagucuaagc cugucccaag gagugcucca gucucugcuu     2040

ccccaguugc uguacugucg gaaguuaaga cucgauacaa aucaguuuca agacccgguc     2100

auggaacugc uuggcucggu gcugagcggg aaagauugca ggauccagaa gaucucccua     2160

gcggagaacc agauuucaaa uaaaggagcc aaggcacucg cucguagucu guugguaaac     2220

cgcucucuga cuagcuuaga ccuccggggc aauuccauag guccucaggg ggccaaggcc     2280

cuggcugaug cacuuaaaau caacagaacc cugacaucau ugagccucca aggaaauacu     2340

gugagggacg auggcgcccg aucuauggcg gaagcucugg ccuccaaccg gacccuaagu     2400

augcugcacc uucagaagaa cagcauuggu ccaaugggcg cacagcgcau ggccgacgcu     2460

cucaaacaga auagaucucu gaaggaguug auguucuccu caaacaguau cggggaugga     2520

ggcgcaaaag cccuggcgga agcguuaaag guuaaucaag ggcucgagag ccuggaccuu     2580

cagucgaacu ccauaucuga ugccggaguc gcagcccuga ugggcgcuuu guguacaaau     2640

cagacccucc ugagccuauc acugagggag aacaguauuu cccccgaagg ugcccaagca     2700

aucgcucaug cccuuugcgc uaauucuacu cucaagaacc uggacuugac ggccaauuua     2760

cugcacgauc agggggcacg ggcuaucgcc guggcugugc gagagaacag aacacucacc     2820

agccugcacc uucaguggaa uuuuauucag gcaggagccg cccaagcucu gggccaggcg     2880

uugcagcuaa accgcucccu gacuucacuc gaccugcagg aaaaugcaau cggugacgau     2940

ggcgccugug cugucgccag ggcacuuaaa guuaacaccg ccuuaacagc ucuguaucuc     3000

caaguggcga gcauuggggc caguggagca cagguguugg gcgaggcucu ggccguaaau     3060

cguacccucg aaauacugga ccuucggggg aacgcaaucg gagucgccgg cgcuaaggcc     3120

cuggcgaacg cauugaaagu uaauucuucc cuaagaaggc ugaaccucca ggagaauagc     3180

uuagguaugg auggggccau uugcaucgcu acugcccugu cgggaaacca ucgccuucag     3240

cacaucaauc ugcaaggcaa ccauauuggu gacucaggcg cucgaaugau aucugaggca     3300

aucaagacaa augccccuac guguaccguu gaaauguga                            3339


<210>  9177
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD3__Homo_sapiens__EAW85351

<400>  9177
auggagaugg acgcccccag accccccagc cuggccgugc ccggcgccgc cagcagaccc       60

ggcagacugc uggacggcgg ccacggcaga cagcaggugc aggcccugag cagccagcug      120

cuggagguga uccccgacag caugagaaag caggagguga gaaccggcag agaggccggc      180

cagggccacg gcaccggcag ccccgccgag caggugaagg cccugaugga ccugcuggcc      240

ggcaagggca gccagggcag ccaggccccc caggcccugg acagaacccc cgacgccccc      300

cugggccccu gcagcaacga cagcagaauc cagagacaca gaaaggcccu gcugagcaag      360

gugggcggcg gccccgagcu gggcggcccc uggcacagac uggccagccu gcugcuggug      420

gagggccuga ccgaccugca gcugagagag cacgacuuca cccaggugga ggccaccaga      480

ggcggcggcc accccgccag aaccguggcc cuggacagac uguuccugcc ccugagcaga      540

gugagcgugc cccccagagu gagcaucacc aucggcgugg ccggcauggg caagaccacc      600

cuggugagac acuucgugag acugugggcc cacggccagg ugggcaagga cuucagccug      660

gugcugcccc ugaccuucag agaccugaac acccacgaga agcugugcgc cgacagacug      720

aucugcagcg uguuccccca cgugggcgag cccagccugg ccguggccgu gcccgccaga      780

gcccugcuga uccuggacgg ccuggacgag ugcagaaccc cccuggacuu cagcaacacc      840

guggccugca ccgaccccaa gaaggagauc cccguggacc accugaucac caacaucauc      900

agaggcaacc uguuccccga ggugagcauc uggaucacca gcagacccag cgccagcggc      960

cagauccccg gcggccuggu ggacagaaug accgagauca gaggcuucaa cgaggaggag     1020

aucaaggugu gccuggagca gauguucccc gaggaccagg cccugcuggg cuggaugcug     1080

agccaggugc aggccgacag agcccuguac cugaugugca ccgugcccgc cuucugcaga     1140

cugaccggca uggcccuggg ccaccugugg agaagcagaa ccggccccca ggacgccgag     1200

cuguggcccc ccagaacccu gugcgagcug uacagcuggu acuucagaau ggcccugagc     1260

ggcgagggcc aggagaaggg caaggccagc cccagaaucg agcagguggc ccacggcggc     1320

agaaagaugg ugggcacccu gggcagacug gccuuccacg gccugcugaa gaagaaguac     1380

guguucuacg agcaggacau gaaggccuuc ggcguggacc uggcccugcu gcagggcgcc     1440

cccugcagcu gcuuccugca gagagaggag acccuggcca gcagcguggc cuacugcuuc     1500

acccaccuga gccugcagga guucguggcc gccgccuacu acuacggcgc cagcagaaga     1560

gccaucuucg accuguucac cgagagcggc gugagcuggc ccagacuggg cuuccugacc     1620

cacuucagaa gcgccgccca gagagccaug caggccgagg acggcagacu ggacguguuc     1680

cugagauucc ugagcggccu gcugagcccc agagugaacg cccugcuggc cggcagccug     1740

cuggcccagg gcgagcacca ggccuacaga acccaggugg ccgagcugcu gcagggcugc     1800

cugagacccg acgccgccgu gugcgccaga gccaucaacg ugcugcacug ccugcacgag     1860

cugcagcaca ccgagcuggc cagaagcgug gaggaggcca uggagagcgg cgcccuggcc     1920

agacugaccg gccccgccca cagagccgcc cuggccuacc ugcugcaggu gagcgacgcc     1980

ugcgcccagg aggccaaccu gagccugagc cugagccagg gcgugcugca gagccugcug     2040

ccccagcugc uguacugcag aaagcugaga cuggacacca accaguucca ggaccccgug     2100

auggagcugc ugggcagcgu gcugagcggc aaggacugca gaauccagaa gaucagccug     2160

gccgagaacc agaucagcaa caagggcgcc aaggcccugg ccagaagccu gcuggugaac     2220

agaagccuga ccagccugga ccugagaggc aacagcaucg gcccccaggg cgccaaggcc     2280

cuggccgacg cccugaagau caacagaacc cugaccagcc ugagccugca gggcaacacc     2340

gugagagacg acggcgccag aagcauggcc gaggcccugg ccagcaacag aacccugagc     2400

augcugcacc ugcagaagaa cagcaucggc cccaugggcg cccagagaau ggccgacgcc     2460

cugaagcaga acagaagccu gaaggagcug auguucagca gcaacagcau cggcgacggc     2520

ggcgccaagg cccuggccga ggcccugaag gugaaccagg gccuggagag ccuggaccug     2580

cagagcaaca gcaucagcga cgccggcgug gccgcccuga ugggcgcccu gugcaccaac     2640

cagacccugc ugagccugag ccugagagag aacagcauca gccccgaggg cgcccaggcc     2700

aucgcccacg cccugugcgc caacagcacc cugaagaacc uggaccugac cgccaaccug     2760

cugcacgacc agggcgccag agccaucgcc guggccguga gagagaacag aacccugacc     2820

agccugcacc ugcaguggaa cuucauccag gccggcgccg cccaggcccu gggccaggcc     2880

cugcagcuga acagaagccu gaccagccug gaccugcagg agaacgccau cggcgacgac     2940

ggcgccugcg ccguggccag agcccugaag gugaacaccg cccugaccgc ccuguaccug     3000

cagguggcca gcaucggcgc cagcggcgcc caggugcugg gcgaggcccu ggccgugaac     3060

agaacccugg agauccugga ccugagaggc aacgccaucg gcguggccgg cgccaaggcc     3120

cuggccaacg cccugaaggu gaacagcagc cugagaagac ugaaccugca ggagaacagc     3180

cugggcaugg acggcgccau cugcaucgcc accgcccuga gcggcaacca cagacugcag     3240

cacaucaacc ugcagggcaa ccacaucggc gacagcggcg ccagaaugau cagcgaggcc     3300

aucaagacca acgcccccac cugcaccgug gagauguga                            3339


<210>  9178
<211>  3339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD3__Homo_sapiens__EAW85351

<400>  9178
auggagaugg acgcccccag accuccgagc cuggcugugc ccggcgccgc gucccggccu       60

gggcgccucc uggauggagg ccacgggaga cagcaagucc aggcucuuuc uagccagcug      120

cucgaaguua uccccgacuc caugcggaag caggaggugc gcaccggaag agaagccggc      180

caagggcaug gaacaggcuc uccugccgaa caggugaaag cucugaugga ucuucuggcc      240

ggcaagggga gccagggauc ccaggcuccc caagcccucg accggacgcc ugaugcgccg      300

cugggccccu gcucuaacga cagccgcauu cagagacacc ggaaagcccu gcucuccaag      360

gucgggggag gcccugagcu ugggggaccc uggcaucgcc uugcuagccu gcuccuggug      420

gagggccuua ccgaucugca gcucagagag cacgacuuca cacagguuga agccacccgg      480

ggcgggggac auccugcucg cacaguggcc cuggauagac uguuucuccc ccugucucgg      540

gucuccgugc cgccucgcgu uagcaucacc auuggcgugg cggggauggg aaaaacaacc      600

cuugucagac acuucgugcg gcugugggcc cacggccaag uggggaagga cuuuucucuc      660

guccugcccc uuacguucag agaucugaau acccaugaga agcucugugc ugaccgccug      720

aucugcuccg uuuuuccuca cgugggagaa cccagccugg ccguggcugu ccccgcccgg      780

gcccuccuga uucuugaugg ccuggacgag uguagaacac cucucgacuu cucuaacacc      840

guggcuugca cagauccgaa aaaggagauc cccguugacc aucugaucac caauauuauc      900

cgcggcaacc uuuuuccuga aguguccauu uggaucacga gccggcccuc cgcgucuggg      960

cagauuccug gaggccuggu cgauagaaug acagagaucc gcggguucaa ugaagaggaa     1020

auuaaagugu gucucgagca gauguuuccc gaggaccaag cccugcuggg auggaugcuc     1080

agccagguuc aggcugaucg ggcccuguac cuuaugugca ccgugccggc cuucuguaga     1140

cugacaggca uggcucucgg gcaccugugg cgcucccgga ccggcccuca ggacgccgaa     1200

cuguggcccc cuagaacccu uugcgagcuc uauagcuggu acuuucgcau ggcgcugucu     1260

ggagaaggcc aagagaaggg gaaagcuagc ccccggaucg aacaggucgc ccacggaggc     1320

agaaagaugg uggggacacu gggacggcuc gccuuccaug gccugcuuaa gaaaaaguau     1380

gucuuuuacg agcaggauau gaaggcuuuc gggguggacc uggcccuccu gcagggcgcu     1440

ccuuguuccu gcuuccugca acgcgaggaa acgcuugccu cuagcguugc guauuguuuu     1500

acccaccucu cccugcagga guucguggcc gcugccuacu auuacggagc uucuagacgg     1560

gccaucuuug aucuguucac agaaagcggc gucuccuggc ccagacucgg guuucugacc     1620

cauuuccgca gcgcggccca gcgggcuaug caggccgagg acggaagacu ugauguguuu     1680

cugcgcuucc ucucuggccu gcuguccccg agaguuaacg cucugcucgc cgggagccug     1740

cuggcccaag gagaacacca ggcuuaccgg acacaggugg cggagcuccu gcagggcugc     1800

cuucgcccug acgccgcugu cugcgccaga gccauuaaug ugcugcauug ucuccacgag     1860

cugcaacaca ccgaacuggc ucggucugug gaggaagcca uggaguccgg ggcgcuugcu     1920

cgccucacgg gccccgccca uagagccgcu cuggccuauc ugcuccaggu uagcgacgcg     1980

ugcgcucagg aggccaaccu gucccuuucu cugagccaag gaguccucca gucccugcug     2040

ccccagcuuc uguacugucg gaaacuccgc cuggauacaa aucaguuuca agacccugug     2100

auggaacucc ugggcucugu gcuuagcggg aaagauugca gaauccagaa gauuucccug     2160

gccgagaacc agaucagcaa uaaaggagcu aaggcccucg cucggucucu gcuggucaac     2220

cgcucccuua ccagccugga ccucagaggc aauucuauug ggccgcaggg agccaaggcg     2280

cuggccgaug cucucaaaau caaccggacc cugacauccc uuagccugca aggcaauacc     2340

gugagagacg auggggcccg cucuauggcu gaagcccucg ccagcaaccg gacacugucc     2400

augcugcacc uucagaagaa cagcaucggc cccaugggag cucagagaau ggcggacgcc     2460

cugaaacaga aucgcucucu caaggagcug auguucucca gcaacuccau uggcgauggg     2520

ggagcuaaag cccucgccga agcucugaag guuaaucaag gccuugaguc ucuggaccug     2580

cagagcaacu ccaucucuga ugccggggug gcggcucuca ugggagcccu guguacgaau     2640

cagacccuuc ugagccucuc ccugcgggag aacucuauua gcccugaagg cgcccaagcu     2700

aucgcccaug cgcucugcgc uaauuccaca cugaagaacc uugaccugac cgccaaucug     2760

cuccacgauc agggcgccag agcuauugcc gucgcugugc gcgagaaccg gacacugacc     2820

agccuucauc ugcaguggaa uuuuauccag gccggggcgg cccaagcucu cggacaggcc     2880

cugcagcuca acagaucucu gacgucccuu gaccugcagg aaaaugcuau cggcgacgau     2940

ggggccugug ccguugcucg cgcgcugaaa gugaacaccg cccucacagc ucuguaucuu     3000

caagucgcca gcauuggagc cucuggcgcu caggugcugg gggaggcccu cgcgguuaau     3060

cggacccugg aaauccucga ccugagagga aacgcuauug gcguggccgg cgccaaggcu     3120

cuugccaacg cgcugaaagu caauuccagc cugcggcgcc ucaaccugca ggaaaauucu     3180

cuugggaugg auggagccau cugcauugcu acagcccugu ccggcaacca cagacuccag     3240

cacaucaauc ugcaagggaa ccauauugga gacagcggcg cucggaugau cuccgaggcc     3300

aucaagacca augcucccac guguacagug gagauguga                            3339


<210>  9179
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__Q7RTR2

<400>  9179

Met Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His 
1               5                   10                  15      


Gly Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu 
            20                  25                  30          


Ala Gly Lys Gly Ser Gln Gly Ser Gln Ala Pro Gln Ala Leu Asp Arg 
        35                  40                  45              


Thr Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln 
    50                  55                  60                  


Arg His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu 
65                  70                  75                  80  


Gly Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu 
                85                  90                  95      


Thr Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr 
            100                 105                 110         


Arg Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe 
        115                 120                 125             


Leu Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile 
    130                 135                 140                 


Gly Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg 
145                 150                 155                 160 


Leu Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro 
                165                 170                 175     


Leu Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg 
            180                 185                 190         


Leu Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val 
        195                 200                 205             


Ala Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys 
    210                 215                 220                 


Arg Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys 
225                 230                 235                 240 


Lys Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn 
                245                 250                 255     


Leu Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser 
            260                 265                 270         


Gly Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly 
        275                 280                 285             


Phe Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu 
    290                 295                 300                 


Asp Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg 
305                 310                 315                 320 


Ala Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly 
                325                 330                 335     


Met Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala 
            340                 345                 350         


Glu Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe 
        355                 360                 365             


Arg Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro 
    370                 375                 380                 


Arg Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr 
                405                 410                 415     


Glu Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly 
            420                 425                 430         


Ala Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser 
        435                 440                 445             


Val Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala 
    450                 455                 460                 


Ala Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr 
465                 470                 475                 480 


Glu Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg 
                485                 490                 495     


Ser Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val 
            500                 505                 510         


Phe Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu 
        515                 520                 525             


Leu Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr 
    530                 535                 540                 


Gln Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val 
545                 550                 555                 560 


Cys Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His 
                565                 570                 575     


Thr Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu 
            580                 585                 590         


Ala Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu 
        595                 600                 605             


Gln Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu 
    610                 615                 620                 


Ser Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu 
                645                 650                 655     


Leu Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser 
            660                 665                 670         


Leu Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg 
        675                 680                 685             


Ser Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn 
    690                 695                 700                 


Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile 
705                 710                 715                 720 


Asn Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp 
                725                 730                 735     


Asp Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu 
            740                 745                 750         


Ser Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln 
        755                 760                 765             


Arg Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met 
    770                 775                 780                 


Phe Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu 
785                 790                 795                 800 


Ala Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn 
                805                 810                 815     


Ser Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr 
            820                 825                 830         


Asn Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro 
        835                 840                 845             


Glu Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu 
    850                 855                 860                 


Lys Asn Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg 
865                 870                 875                 880 


Ala Ile Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His 
                885                 890                 895     


Leu Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln 
            900                 905                 910         


Ala Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn 
        915                 920                 925             


Ala Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val 
    930                 935                 940                 


Asn Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser Ile Gly Ala 
945                 950                 955                 960 


Ser Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn Arg Thr Leu 
                965                 970                 975     


Glu Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala Gly Ala Lys 
            980                 985                 990         


Ala Leu Ala Asn Ala Leu Lys Val Asn Ser Ser Leu Arg Arg Leu Asn 
        995                 1000                1005            


Leu Gln Glu Asn Ser Leu Gly Met Asp Gly Ala Ile Cys Ile Ala Thr 
    1010                1015                1020                


Ala Leu Ser Gly Asn His Arg Leu Gln His Ile Asn Leu Gln Gly Asn 
1025                1030                1035                1040


His Ile Gly Asp Ser Gly Ala Arg Met Ile Ser Glu Ala Ile Lys Thr 
                1045                1050                1055    


Asn Ala Pro Thr Cys Thr Val Glu Met 
            1060                1065


<210>  9180
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  NOD3__Homo_sapiens__AAT48367

<400>  9180
augaggaagc aagaggugcg gacgggcagg gaggccggcc agggccacgg uacgggcucc       60

ccagccgagc aggugaaagc ccucauggau cugcuggcug ggaagggcag ucaaggcucc      120

caggccccgc aggcccugga uaggacaccg gaugccccgc uggggcccug cagcaaugac      180

ucaaggauac agaggcaccg caaggcccug cugagcaagg ugggaggugg cccggagcug      240

ggcggacccu ggcacaggcu ggccucccuc cugcuggugg agggccugac ggaccugcag      300

cugagggaac acgacuucac acagguggag gccacccgcg ggggcgggca ccccgccagg      360

accgucgccc uggaccggcu cuuccugccu cucucccggg ugucuguccc accccggguc      420

uccaucacua ucgggguggc cggcaugggc aagaccaccc uggugaggca cuucguccgc      480

cucugggccc augggcaggu cggcaaggac uucucgcugg ugcugccucu gaccuuccgg      540

gaucucaaca cccacgagaa gcugugugcc gaccgacuca ucugcucggu cuucccgcac      600

gucggggagc ccagccuggc gguggcaguc ccagccaggg cccuccugau ccuggacggc      660

uuggaugagu gcaggacgcc ucuggacuuc uccaacaccg uggccugcac ggacccaaag      720

aaggagaucc cgguggacca ccugaucacc aacaucaucc guggcaaccu cuuuccggaa      780

guuuccaucu ggaucaccuc ccgucccagu gcaucuggcc agaucccagg gggccuggug      840

gaccggauga cggagauccg gggcuuuaac gaggaggaga ucaaggugug uuuggagcag      900

auguuccccg aggaccaggc ccuucugggc uggaugcuga gccaagugca ggcugacagg      960

gcccuguacc ugaugugcac cgucccagcc uucugcaggc ucacggggau ggcgcuaggc     1020

caccuguggc gcagcaggac ggggccccag gaugcagagc uguggccccc gaggacccug     1080

ugcgagcucu acucauggua cuuuaggaug gcccucagcg gggaggggca ggagaagggc     1140

aaggcaagcc cucgcaucga gcagguggcc caugguggcc gcaagauggu ggggacauug     1200

ggccgucugg ccuuccaugg gcugcucaag aagaaauacg uguuuuacga gcaagacaug     1260

aaggcguuug guguagaccu cgcucugcug cagggcgccc cgugcagcug cuuccugcag     1320

agagaggaga cguuggcauc gucaguggcc uacugcuuca cccaccuguc ccugcaggag     1380

uuuguggcag ccgcguauua cuauggcgca uccaggaggg ccaucuucga ccucuucacu     1440

gagagcggcg uauccuggcc caggcugggc uuccucacgc auuucaggag cgcagcccag     1500

cgggccaugc aggcagagga cgggaggcug gacguguucc ugcgcuuccu cuccggccuc     1560

uugucuccga gggucaaugc ccuccuggcc ggcucccugc uggcccaagg cgagcaccag     1620

gccuaccgga cccagguggc ugagcuccug cagggcugcc ugcgccccga ugccgcaguc     1680

ugugcacggg ccaucaacgu guugcacugc cugcaugagc ugcagcacac ugagcuggcc     1740

cgcagcgugg aggaggccau ggagagcggg gcccuggcca ggcugaccgg ucccgcgcac     1800

cgcgcugccc uggccuaccu ccugcaggug uccgacgccu gugcccagga ggccaaccug     1860

ucccugagcc ucagccaggg cguccuucag agccugcugc cccagcugcu cuacugccgg     1920

aagcucaggc uggacaccaa ccaguuccag gaccccguga uggagcugcu gggcagcgug     1980

cugaguggga aggacugucg cauucagaag aucagcuugg cggagaacca gaucaguaac     2040

aaaggggcca aagcucuggc cagaucccuc uuggucaaca gaagucugac cucucuggac     2100

cuccgcggua acuccauugg accacaaggg gccaaggcgc uggcagacgc uuugaagauc     2160

aaccgcaccc ugaccucccu gagccuccag ggcaacaccg uuagggauga uggugccagg     2220

uccauggcug aggccuuggc cuccaaccgg acccucucca ugcugcaccu gcagaagaac     2280

agcaucgggc ccaugggagc ccagcggaug gcagaugccu ugaagcagaa caggagucug     2340

aaagagcuca uguucuccag uaauaguauu ggugauggag gugccaaggc ccuggcugag     2400

gcccugaagg ugaaccaggg ccuggagagc cuggaccugc agagcaauuc caucagugac     2460

gcaggagugg cagcacugau gggggcccuc ugcaccaacc agacccuccu cagccucagc     2520

cuucgagaaa acuccaucag ucccgaggga gcccaggcca ucgcucaugc ccucugcgcc     2580

aacagcaccc ugaagaaccu ggaccugaca gccaaccucc uccacgacca gggugcccgg     2640

gccaucgcag uggcagugag agaaaaccgc acccucaccu cccuucaccu gcaguggaac     2700

uucauccagg ccggcgcugc ccaggcccug ggacaagcac uacagcucaa caggagccuc     2760

accagcuuag auuuacagga gaacgccauc ggggaugacg gagcgugugc gguggcccgu     2820

gcacugaagg ucaacacagc ccucacugcu cucuaucucc agguggccuc aauuggugcu     2880

ucaggcgccc aggugcuagg ggaagccuug gcugugaaca gaaccuugga gauucucgac     2940

uuaagaggaa augccauugg gguggcugga gccaaagccc uggcaaaugc ucugaaggua     3000

aacucaaguc uccggagacu caaucuucaa gagaauucuc uggggaugga cggggcgaua     3060

ugcauugcca cagcacuguc uggaaaccac aggcuccagc auaucaaucu ccagggaaac     3120

cacauugggg acuccggggc caggaugauc ucagaggcca ucaagacaaa ugcucccacg     3180

ugcacuguug aaauguga                                                   3198


<210>  9181
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       NOD3__Homo_sapiens__AAT48367

<400>  9181
augcgcaagc aggaggugcg gaccggccgc gaggccgggc agggccacgg gaccggcagc       60

cccgccgagc aggucaaggc gcugauggac cuccuggccg ggaagggcuc ccagggcagc      120

caggccccgc aggcccugga ccggaccccc gacgcgcccc ucgggcccug cuccaacgac      180

agccgcaucc agcggcaccg caaggcccug cuguccaagg ugggcggggg cccggagcuc      240

gggggccccu ggcaccggcu ggccagccug cuccuggugg agggccugac cgaccuccag      300

cugcgcgagc acgacuucac ccaggucgag gccacccgcg ggggcgggca ccccgcccgg      360

acgguggcgc uggaccggcu guuccugccc cugucccgcg ugagcguccc gccccgggug      420

uccaucacca ucggcguggc cggcaugggg aagaccaccc ucguccgcca cuucgugcgg      480

cugugggccc acggccaggu ggggaaggac uucagccugg uccucccccu gacguuccgc      540

gaccugaaca cccacgagaa gcucugcgcc gaccggcuga ucugcuccgu guucccccac      600

gugggcgagc cgagccuggc cgucgcggug cccgcccgcg cccuccugau ccuggacggg      660

cucgacgagu gccggacgcc ccuggacuuc uccaacaccg uggccugcac cgaccccaag      720

aaggagaucc cggucgacca ccugaucacc aacaucaucc gcggcaaccu cuuccccgag      780

gugagcaucu ggaucaccuc ccggcccagc gccuccggcc agauccccgg gggccuggug      840

gaccgcauga ccgagauccg cggguucaac gaggaggaga ucaaggucug ccuggagcag      900

auguucccgg aggaccaggc gcuccugggc uggaugcuga gccaggugca ggccgaccgg      960

gcccucuacc ugaugugcac ggugcccgcc uucugccgcc ugaccgggau ggcccucggc     1020

caccuguggc ggucccgcac cggcccccag gacgcggagc uguggccccc gcggacccuc     1080

ugcgagcugu acagcuggua cuuccgcaug gcccugagcg gggagggcca ggagaagggg     1140

aaggccagcc cccggaucga gcaggucgcc cacggcgggc gcaagauggu gggcacgcuc     1200

ggccggcugg ccuuccacgg gcugcugaag aagaaguacg ucuucuacga gcaggacaug     1260

aaggcguucg gcguggaccu cgcccugcug cagggggccc ccugcuccug cuuccuccag     1320

cgcgaggaga cccuggccuc cagcguggcg uacugcuuca cccaccuguc ccuccaggag     1380

uucgucgccg ccgccuacua cuacggcgcc agccggcgcg cgaucuucga ccuguucacc     1440

gaguccggcg ugagcuggcc ccggcugggg uuccucacgc acuuccgcuc cgccgcccag     1500

cgggccaugc aggccgagga cggccgccug gacguguucc ugcgguuccu cagcgggcug     1560

cuguccccgc gcgucaacgc gcuccuggcc ggcagccugc ucgcccaggg ggagcaccag     1620

gccuaccgga cccagguggc cgagcugcug cagggcugcc uccgccccga cgcggccgug     1680

ugcgcccgcg ccaucaacgu ccugcacugc cugcacgagc uccagcacac cgagcuggcg     1740

cgguccgugg aggaggccau ggagagcggc gcccuggccc gccucaccgg gcccgcccac     1800

cgggcggccc uggccuaccu gcuccaggug uccgacgccu gcgcccagga ggcgaaccug     1860

agccuguccc ucagccaggg cguccugcag ucccugcucc cgcagcugcu guacugccgc     1920

aagcuccggc uggacacgaa ccaguuccag gaccccguga uggagcugcu cgggagcgug     1980

cugagcggca aggacugccg cauccagaag aucucccugg ccgagaacca gaucagcaac     2040

aagggggcca aggcccucgc ccggucccug cuggucaacc gcagccucac cucccuggac     2100

cugcggggca acagcaucgg cccccagggg gcgaaggccc ucgccgacgc ccugaagauc     2160

aaccgcaccc ugaccucccu cagccugcag ggcaacacgg ugcgggacga cggggcgcgc     2220

uccauggccg aggcccuggc cagcaaccgg acccucucca ugcugcaccu ccagaagaac     2280

agcaucggcc ccaugggggc ccagcgcaug gcggacgccc ucaagcagaa ccggucccug     2340

aaggagcuga uguucagcuc caacagcauc ggcgacggcg gggccaaggc ccucgccgag     2400

gcgcugaagg ugaaccaggg ccuggagucc cucgaccugc agagcaacag caucuccgac     2460

gccggggucg ccgcccugau gggcgcccuc ugcaccaacc agacccugcu gagccucucc     2520

cugcgcgaga acagcaucuc cccggagggg gcgcaggcca ucgcccacgc ccugugcgcc     2580

aacagcacgc ucaagaaccu ggaccugacc gcgaaccucc ugcacgacca gggcgcccgg     2640

gccaucgccg uggcggugcg cgagaaccgg acccugaccu cccuccaccu ccaguggaac     2700

uucauccagg ccggcgccgc ccaggcccug gggcaggcgc ugcagcugaa ccgcagccug     2760

accucccucg accugcagga gaacgccauc ggcgacgacg gggccugcgc cgucgcccgg     2820

gcgcugaagg ugaacacggc ccucaccgcc cuguaccucc agguggccag caucggcgcc     2880

uccggcgcgc agguccuggg ggaggcccug gccgugaacc gcacccugga gauccuggac     2940

cuccgcggca acgccaucgg gguggcgggc gccaaggccc uggccaacgc ccugaagguc     3000

aacagcuccc uccggcgccu gaaccugcag gagaacagcc ucgggaugga cggcgcgauc     3060

ugcaucgcca ccgcccuguc cggcaaccac cggcugcagc acaucaaccu ccaggggaac     3120

cacaucggcg acagcggggc ccgcaugauc uccgaggcca ucaagacgaa cgcgcccacg     3180

ugcaccgugg agauguga                                                   3198


<210>  9182
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       NOD3__Homo_sapiens__AAT48367

<400>  9182
augcgcaagc aggagguccg caccggccgc gaggccggcc agggccacgg caccggcucc       60

cccgccgagc aggucaaggc ccucauggac cuccucgccg gcaagggcuc ccagggcucc      120

caggcccccc aggcccucga ccgcaccccc gacgcccccc ucggccccug cuccaacgac      180

ucccgcaucc agcgccaccg caaggcccuc cucuccaagg ucggcggcgg ccccgagcuc      240

ggcggccccu ggcaccgccu cgccucccuc cuccucgucg agggccucac cgaccuccag      300

cuccgcgagc acgacuucac ccaggucgag gccacccgcg gcggcggcca ccccgcccgc      360

accgucgccc ucgaccgccu cuuccucccc cucucccgcg ucuccguccc cccccgcguc      420

uccaucacca ucggcgucgc cggcaugggc aagaccaccc ucguccgcca cuucguccgc      480

cucugggccc acggccaggu cggcaaggac uucucccucg uccucccccu caccuuccgc      540

gaccucaaca cccacgagaa gcucugcgcc gaccgccuca ucugcuccgu cuucccccac      600

gucggcgagc ccucccucgc cgucgccguc cccgcccgcg cccuccucau ccucgacggc      660

cucgacgagu gccgcacccc ccucgacuuc uccaacaccg ucgccugcac cgaccccaag      720

aaggagaucc ccgucgacca ccucaucacc aacaucaucc gcggcaaccu cuuccccgag      780

gucuccaucu ggaucaccuc ccgccccucc gccuccggcc agauccccgg cggccucguc      840

gaccgcauga ccgagauccg cggcuucaac gaggaggaga ucaaggucug ccucgagcag      900

auguuccccg aggaccaggc ccuccucggc uggaugcucu cccaggucca ggccgaccgc      960

gcccucuacc ucaugugcac cguccccgcc uucugccgcc ucaccggcau ggcccucggc     1020

caccucuggc gcucccgcac cggcccccag gacgccgagc ucuggccccc ccgcacccuc     1080

ugcgagcucu acuccuggua cuuccgcaug gcccucuccg gcgagggcca ggagaagggc     1140

aaggccuccc cccgcaucga gcaggucgcc cacggcggcc gcaagauggu cggcacccuc     1200

ggccgccucg ccuuccacgg ccuccucaag aagaaguacg ucuucuacga gcaggacaug     1260

aaggccuucg gcgucgaccu cgcccuccuc cagggcgccc ccugcuccug cuuccuccag     1320

cgcgaggaga cccucgccuc cuccgucgcc uacugcuuca cccaccucuc ccuccaggag     1380

uucgucgccg ccgccuacua cuacggcgcc ucccgccgcg ccaucuucga ccucuucacc     1440

gaguccggcg ucuccuggcc ccgccucggc uuccucaccc acuuccgcuc cgccgcccag     1500

cgcgccaugc aggccgagga cggccgccuc gacgucuucc uccgcuuccu cuccggccuc     1560

cucucccccc gcgucaacgc ccuccucgcc ggcucccucc ucgcccaggg cgagcaccag     1620

gccuaccgca cccaggucgc cgagcuccuc cagggcugcc uccgccccga cgccgccguc     1680

ugcgcccgcg ccaucaacgu ccuccacugc cuccacgagc uccagcacac cgagcucgcc     1740

cgcuccgucg aggaggccau ggaguccggc gcccucgccc gccucaccgg ccccgcccac     1800

cgcgccgccc ucgccuaccu ccuccagguc uccgacgccu gcgcccagga ggccaaccuc     1860

ucccucuccc ucucccaggg cguccuccag ucccuccucc cccagcuccu cuacugccgc     1920

aagcuccgcc ucgacaccaa ccaguuccag gaccccguca uggagcuccu cggcuccguc     1980

cucuccggca aggacugccg cauccagaag aucucccucg ccgagaacca gaucuccaac     2040

aagggcgcca aggcccucgc ccgcucccuc cucgucaacc gcucccucac cucccucgac     2100

cuccgcggca acuccaucgg cccccagggc gccaaggccc ucgccgacgc ccucaagauc     2160

aaccgcaccc ucaccucccu cucccuccag ggcaacaccg uccgcgacga cggcgcccgc     2220

uccauggccg aggcccucgc cuccaaccgc acccucucca ugcuccaccu ccagaagaac     2280

uccaucggcc ccaugggcgc ccagcgcaug gccgacgccc ucaagcagaa ccgcucccuc     2340

aaggagcuca uguucuccuc caacuccauc ggcgacggcg gcgccaaggc ccucgccgag     2400

gcccucaagg ucaaccaggg ccucgagucc cucgaccucc aguccaacuc caucuccgac     2460

gccggcgucg ccgcccucau gggcgcccuc ugcaccaacc agacccuccu cucccucucc     2520

cuccgcgaga acuccaucuc ccccgagggc gcccaggcca ucgcccacgc ccucugcgcc     2580

aacuccaccc ucaagaaccu cgaccucacc gccaaccucc uccacgacca gggcgcccgc     2640

gccaucgccg ucgccguccg cgagaaccgc acccucaccu cccuccaccu ccaguggaac     2700

uucauccagg ccggcgccgc ccaggcccuc ggccaggccc uccagcucaa ccgcucccuc     2760

accucccucg accuccagga gaacgccauc ggcgacgacg gcgccugcgc cgucgcccgc     2820

gcccucaagg ucaacaccgc ccucaccgcc cucuaccucc aggucgccuc caucggcgcc     2880

uccggcgccc agguccucgg cgaggcccuc gccgucaacc gcacccucga gauccucgac     2940

cuccgcggca acgccaucgg cgucgccggc gccaaggccc ucgccaacgc ccucaagguc     3000

aacuccuccc uccgccgccu caaccuccag gagaacuccc ucggcaugga cggcgccauc     3060

ugcaucgcca ccgcccucuc cggcaaccac cgccuccagc acaucaaccu ccagggcaac     3120

cacaucggcg acuccggcgc ccgcaugauc uccgaggcca ucaagaccaa cgcccccacc     3180

ugcaccgucg agauguga                                                   3198


<210>  9183
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       NOD3__Homo_sapiens__AAT48367

<400>  9183
augagaaagc aggaggugag gaccggccgg gaagccgggc aaggacacgg uacaggcagc       60

cccgcugagc aggucaaagc acugauggac cuccuugccg ggaagggauc ccagggcucu      120

caggcgccuc aagcucugga ucgcacucca gacgccccgu ugggucccug cucaaacgau      180

agucgaaucc agcgucauag aaaagcauua cugagcaagg uugggggagg cccugaacua      240

ggcgggccau ggcacaggcu cgccucccug cuucuggugg agggauugac ggaccuccag      300

cugcgggaac augauuucac ccagguagag gcuacacgcg guggcgggca ccccgcaaga      360

acuguggccc uggacaggcu cuuuuuaccu cugucucggg ucucggugcc accccgcguu      420

ucaauuacca uaggaguggc uggcaugggu aaaacaaccc uuguccgaca uuucgugaga      480

uugugggccc acgggcaagu aggaaaggau uuuagccugg uucuaccucu cacuuucagg      540

gaccugaaua cacacgagaa acuuugugcg gaucggcuga ucugcagugu guuuccacau      600

gucggcgaac cguccuuggc aguggccgug cccgcucgug cccuccugau uuuagacggc      660

cuggaugagu gucgcacccc ucucgacuuc ucuaacacgg ucgcaugcac ugaucccaaa      720

aaggaaaucc caguugacca ccuuauuacc aauaucauaa gagggaaccu guuuccugag      780

gugagcaucu ggauuacauc caggccauca gcuaguggac agauccccgg uggcuuggua      840

gaccggauga cugagauucg aggguucaau gaagaggaaa ucaaagugug ucuagagcag      900

auguuuccgg aagaucaggc ccugcucgga uggaugcuga gccaagucca ggcggaccgc      960

gcccuuuacc ugaugugcac cgugccugca uucuguagau ugacaggcau ggcucucggu     1020

caucugugga ggucucggac cgggccccag gaugccgagu uauggccacc ucgcacgcug     1080

ugcgagcuau auuccuggua cuuuagaaug gcucucucag gcgaaggaca agagaagggc     1140

aaagccagcc ccaggauaga acagguugca cacgggggac guaagauggu ggguacucug     1200

ggccggcuug ccuuccacgg guugcugaag aaaaaguaug ucuuuuacga gcaggacaug     1260

aaggcuuucg gaguggaucu cgcgcugcuu cagggcgcac cauguaguug cuuccugcaa     1320

cgagaagaga cauuggccuc uuccguagcu uauuguuuua cccaucucag ccugcaggag     1380

uucguugccg cagccuacua uuacggugcu ucgagaaggg ccauuuuuga cuuauucacu     1440

gaaucugggg uguccuggcc ccgccugggc uuucuaacac acuuccgguc agcagcgcag     1500

agagcuaugc aggccgagga uggaaggcuc gacgucuuuc ugcgcuuccu uaguggcuug     1560

cugagcccuc gagugaacgc acuccuggcc ggguccuuac uggcucaagg agaacaucag     1620

gccuaccgga cccaggucgc agagcuuuug caggguugcc uccguccaga ugcugccgug     1680

ugcgcgagag ccaucaaugu ucugcacugu cuacaugaac ugcaacacac ggagcucgcu     1740

aggucugugg aggaagcaau ggagagcggc gcccuggcuc gccuuaccgg gccggcccac     1800

cgggcagcgu uggccuaucu guuacaggua ucagacgcuu gcgcccagga agcaaaccuc     1860

agucuguccc uuagccaggg aguccugcaa ucuuugcucc cccagcugcu auacuguaga     1920

aagcugaggc ucgauacaaa ucaguuucaa gacccuguga uggagcugcu uggcucaguu     1980

uugaguggua aagacugccg cauucagaag aucagccugg cugagaacca gaucuccaau     2040

aaaggggcca aggcauuagc ccgaucucuc cuggugaacc ggucgcuuac uagccuggau     2100

cuaagaggca auuccauugg accacagggc gcuaaggcgc ucgccgacgc acugaaaaua     2160

aacaggaccu ugacaucacu gaguuuacaa gggaauacug uccgugauga cggagcucgc     2220

ucuauggccg aagcccucgc uagcaaccgg acccugucca ugcuucaucu gcagaagaac     2280

ucaaucggcc ccaugggugc acagagaaug gccgaugcgu ugaaacagaa uaggagccuc     2340

aaggagcuga uguucucuuc caacaguauu ggggacggag gcgcuaaagc ccuagcagaa     2400

gcccugaagg ugaaucaagg ucuugagagc cucgaucugc agucuaacuc caucucagac     2460

gcuggcguag cagccuugau gggggcgcug uguacaaauc agaccuuacu cagucugagc     2520

cuucgagaaa acucgauauc cccugaggga gcucaggcca uugcacacgc ccugugcgcu     2580

aauucuacuu ugaagaaccu cgaucugacg gccaaucuac ugcaugacca aggcgcacgg     2640

gcuaucgccg uggcgguucg cgagaacaga acacuuacca gccuccaucu gcaguggaau     2700

uuuauccagg ccggggcagc ucaagccuug ggacaggcuu uacagcugaa caggucacuc     2760

acuucacugg aucuucagga aaaugcaauu ggcgacgaug gugccugugc cgucgcucgg     2820

gcgcugaaag ugaacaccgc auugacagcc cuauaucugc aaguggcuuc caucggggcc     2880

ucuggagcac agguccucgg cgaggcccug gcuguuaauc gaacccuuga aauuuuagac     2940

cugagaggua acgcgauagg cguggccggg gcaaaggcuc ucgccaacgc auugaaagug     3000

aauagcuccc ugcgcaggcu caaccugcag gagaauaguc uuggaaugga cggcgccauc     3060

ugcauugcua cugcccugag cgggaaccac cguuugcagc acaucaaucu acaaggaaac     3120

cacaucggcg auaguggugc gcggaugauu ucugaagcaa uaaagacaaa ugccccaacg     3180

uguaccguag agauguga                                                   3198


<210>  9184
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       NOD3__Homo_sapiens__AAT48367

<400>  9184
augagaaagc aggaggugag aaccggcaga gaggccggcc agggccacgg caccggcagc       60

cccgccgagc aggugaaggc ccugauggac cugcuggccg gcaagggcag ccagggcagc      120

caggcccccc aggcccugga cagaaccccc gacgcccccc ugggccccug cagcaacgac      180

agcagaaucc agagacacag aaaggcccug cugagcaagg ugggcggcgg ccccgagcug      240

ggcggccccu ggcacagacu ggccagccug cugcuggugg agggccugac cgaccugcag      300

cugagagagc acgacuucac ccagguggag gccaccagag gcggcggcca ccccgccaga      360

accguggccc uggacagacu guuccugccc cugagcagag ugagcgugcc ccccagagug      420

agcaucacca ucggcguggc cggcaugggc aagaccaccc uggugagaca cuucgugaga      480

cugugggccc acggccaggu gggcaaggac uucagccugg ugcugccccu gaccuucaga      540

gaccugaaca cccacgagaa gcugugcgcc gacagacuga ucugcagcgu guucccccac      600

gugggcgagc ccagccuggc cguggccgug cccgccagag cccugcugau ccuggacggc      660

cuggacgagu gcagaacccc ccuggacuuc agcaacaccg uggccugcac cgaccccaag      720

aaggagaucc ccguggacca ccugaucacc aacaucauca gaggcaaccu guuccccgag      780

gugagcaucu ggaucaccag cagacccagc gccagcggcc agauccccgg cggccuggug      840

gacagaauga ccgagaucag aggcuucaac gaggaggaga ucaaggugug ccuggagcag      900

auguuccccg aggaccaggc ccugcugggc uggaugcuga gccaggugca ggccgacaga      960

gcccuguacc ugaugugcac cgugcccgcc uucugcagac ugaccggcau ggcccugggc     1020

caccugugga gaagcagaac cggcccccag gacgccgagc uguggccccc cagaacccug     1080

ugcgagcugu acagcuggua cuucagaaug gcccugagcg gcgagggcca ggagaagggc     1140

aaggccagcc ccagaaucga gcagguggcc cacggcggca gaaagauggu gggcacccug     1200

ggcagacugg ccuuccacgg ccugcugaag aagaaguacg uguucuacga gcaggacaug     1260

aaggccuucg gcguggaccu ggcccugcug cagggcgccc ccugcagcug cuuccugcag     1320

agagaggaga cccuggccag cagcguggcc uacugcuuca cccaccugag ccugcaggag     1380

uucguggccg ccgccuacua cuacggcgcc agcagaagag ccaucuucga ccuguucacc     1440

gagagcggcg ugagcuggcc cagacugggc uuccugaccc acuucagaag cgccgcccag     1500

agagccaugc aggccgagga cggcagacug gacguguucc ugagauuccu gagcggccug     1560

cugagcccca gagugaacgc ccugcuggcc ggcagccugc uggcccaggg cgagcaccag     1620

gccuacagaa cccagguggc cgagcugcug cagggcugcc ugagacccga cgccgccgug     1680

ugcgccagag ccaucaacgu gcugcacugc cugcacgagc ugcagcacac cgagcuggcc     1740

agaagcgugg aggaggccau ggagagcggc gcccuggcca gacugaccgg ccccgcccac     1800

agagccgccc uggccuaccu gcugcaggug agcgacgccu gcgcccagga ggccaaccug     1860

agccugagcc ugagccaggg cgugcugcag agccugcugc cccagcugcu guacugcaga     1920

aagcugagac uggacaccaa ccaguuccag gaccccguga uggagcugcu gggcagcgug     1980

cugagcggca aggacugcag aauccagaag aucagccugg ccgagaacca gaucagcaac     2040

aagggcgcca aggcccuggc cagaagccug cuggugaaca gaagccugac cagccuggac     2100

cugagaggca acagcaucgg cccccagggc gccaaggccc uggccgacgc ccugaagauc     2160

aacagaaccc ugaccagccu gagccugcag ggcaacaccg ugagagacga cggcgccaga     2220

agcauggccg aggcccuggc cagcaacaga acccugagca ugcugcaccu gcagaagaac     2280

agcaucggcc ccaugggcgc ccagagaaug gccgacgccc ugaagcagaa cagaagccug     2340

aaggagcuga uguucagcag caacagcauc ggcgacggcg gcgccaaggc ccuggccgag     2400

gcccugaagg ugaaccaggg ccuggagagc cuggaccugc agagcaacag caucagcgac     2460

gccggcgugg ccgcccugau gggcgcccug ugcaccaacc agacccugcu gagccugagc     2520

cugagagaga acagcaucag ccccgagggc gcccaggcca ucgcccacgc ccugugcgcc     2580

aacagcaccc ugaagaaccu ggaccugacc gccaaccugc ugcacgacca gggcgccaga     2640

gccaucgccg uggccgugag agagaacaga acccugacca gccugcaccu gcaguggaac     2700

uucauccagg ccggcgccgc ccaggcccug ggccaggccc ugcagcugaa cagaagccug     2760

accagccugg accugcagga gaacgccauc ggcgacgacg gcgccugcgc cguggccaga     2820

gcccugaagg ugaacaccgc ccugaccgcc cuguaccugc agguggccag caucggcgcc     2880

agcggcgccc aggugcuggg cgaggcccug gccgugaaca gaacccugga gauccuggac     2940

cugagaggca acgccaucgg cguggccggc gccaaggccc uggccaacgc ccugaaggug     3000

aacagcagcc ugagaagacu gaaccugcag gagaacagcc ugggcaugga cggcgccauc     3060

ugcaucgcca ccgcccugag cggcaaccac agacugcagc acaucaaccu gcagggcaac     3120

cacaucggcg acagcggcgc cagaaugauc agcgaggcca ucaagaccaa cgcccccacc     3180

ugcaccgugg agauguga                                                   3198


<210>  9185
<211>  3198
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       NOD3__Homo_sapiens__AAT48367

<400>  9185
augagaaagc aggaggugcg gaccggccgc gaagccgggc aaggacacgg cacagggagc       60

cccgcugagc aggucaaagc ccugauggac cuccuggcgg gaaagggcuc ccaggggucu      120

caggcuccuc aagcccuuga uagaacgccg gacgcucccc ugggaccuug cagcaacgau      180

ucccggaucc agcgccauag aaaagcccuc cugucuaagg uuggcggcgg gcccgaacuu      240

ggaggcccuu ggcaccggcu ggccagccuc cugcuggugg aggggcucac cgaccugcag      300

cuucgcgaac augauuucac acagguggag gcuaccagag gaggcgggca ccccgcccgg      360

acagucgcgc uggaccgccu cuuucugccu cuuuccagag ugucuguucc gccccgggug      420

agcauuacca ucggagucgc cggcaugggc aaaacaaccc uggugcgcca uuucguuaga      480

cucugggcuc acgggcaagu gggaaaggau uuuucccugg uccugccucu cacguuccgg      540

gaccugaaua cccacgagaa acuuugugcc gaucgccuga uuugcagcgu guuuccccau      600

gugggcgaac cuucucucgc ugucgccguu cccgcgagag cccugcuuau ccuggacggg      660

cucgaugagu gucggacacc gcuggacuuc uccaacaccg uggcuugcac agauccuaag      720

aaggaaauuc ccguggacca ccugaucacc aauaucauua gaggaaaccu cuuuccugag      780

gucagcaucu ggauuacguc ucgccccucc gccagcggcc agauccccgg gggacuggug      840

gaccggauga cagagauuag aggcuucaau gaagaggaaa ucaaaguuug ucuugagcag      900

auguuuccug aagaucaggc ucugcucggc uggaugcugu cucaagugca ggccgaccgc      960

gcccuuuacc ugaugugcac cgucccggcu uucugucggc ucacagggau ggcgcuggga     1020

caucugugga gaucccgcac cggcccccag gaugccgagc ucuggccucc ccggacccug     1080

ugcgagcuuu auagcuggua cuuuagaaug gcucuguccg gggaaggaca agagaagggc     1140

aaagccucuc cucgcauuga acagguggcc cacgggggcc ggaagauggu uggaacacuc     1200

ggcagacugg cuuuccacgg gcugcuuaag aaaaaguaug uguuuuacga gcaggacaug     1260

aaagccuucg gagucgaucu cgcgcugcug cagggcgcuc ccuguagcug cuuccuccaa     1320

cgcgaagaga cgcuggccuc cagcguggcc uauuguuuua cccaucuuuc ucugcaggag     1380

uucgucgcug ccgcuuacua uuacggggcc ucccggagag cgaucuuuga ccucuucaca     1440

gaaagcggag ugucuuggcc gcggcugggc uuucugaccc acuuccgcag cgccgcucag     1500

agagccaugc aggcugagga ugggcggcuu gacguuuuuc ucagauuccu guccggccug     1560

cucucuccuc gcgugaacgc ccugcuugcg ggaagccugc ucgcccaagg cgaacaucag     1620

gcuuaccgga cacaggucgc cgagcugcug caggggugcc uuagacccga ugcugccgug     1680

ugcgcccgcg cuaucaaugu ucuccacugu cugcaugaac ugcaacacac cgagcucgcg     1740

agauccgugg aggaagccau ggagagcgga gcucuggccc ggcuuacggg cccugcccac     1800

cgcgcugccc uggcguaucu ccugcagguc ucugacgcuu gcgcccagga agccaaccug     1860

ucccuuagcc ucucucaggg ggugcugcaa ucccugcucc cccagcugcu uuacuguaga     1920

aagcugcggc ucgauacaaa ucaguuucaa gacccuguga uggagcugcu gggaagcguu     1980

cuuuccggca aagacugccg cauucagaag aucucucugg cugagaacca gauuagcaau     2040

aaaggggcca aggcgcucgc uagaucccug cucgucaacc ggucucugac cagccuugau     2100

cugcgcggca auuccaucgg accccagggc gccaaggccc ucgcugacgc ccugaaaauu     2160

aacagaaccc ugacaagccu uucucugcaa gggaauaccg ugcgggauga cggagcucgc     2220

uccauggccg aagcgcucgc cagcaacaga acacugucua ugcuccaucu gcagaagaac     2280

uccaucggcc cgaugggggc ucagcggaug gccgaugcuc uuaaacagaa uagaagccug     2340

aaggagcuca uguucucuag caacuccauc ggagacggcg gggccaaagc ccuggcugaa     2400

gcgcugaagg ugaaucaagg ccuugagagc cuggaucucc agucuaacuc cauuagcgac     2460

gccggagucg cugcccugau gggcgcccuc uguacgaauc agacccugcu uucccugucu     2520

cugcgcgaaa acagcaucuc cccugagggg gcucaggcca uugcgcacgc ucucugcgcc     2580

aauucuacac ugaagaaccu ugaucugacc gccaaucucc ugcaugacca aggagcucgg     2640

gccaucgcgg uggcuguuag agagaaccgc acacucacca gccugcaccu ucaguggaau     2700

uuuauucagg ccggcgccgc ucaagcccug gggcaggcuc ugcagcucaa ccggucccug     2760

acgucucuug aucugcagga aaaugccauc ggagacgaug gcgcgugugc cguggcuaga     2820

gcccucaaag ucaacaccgc ucugacagcc cucuaucugc aaguggccag caucggcgcu     2880

uccggggcgc agguucuugg agaggcccug gcugugaauc gcacccugga aauucucgac     2940

cugcggggca acgccaucgg ggucgccgga gcuaaggccc uugcgaacgc ucugaaagug     3000

aauagcucuc ucagacgccu gaaccuccag gaaaauuccc ugggcaugga cggggccauu     3060

ugcaucgcca cagcucuuag cggaaaccac cggcugcagc auauuaaucu gcaaggcaac     3120

cacaucggcg auucuggggc cagaaugauu uccgaggcga ucaagaccaa ugcccccacg     3180

uguacaguug agauguga                                                   3198


<210>  9186
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__O00329

<400>  9186

Met Pro Pro Gly Val Asp Cys Pro Met Glu Phe Trp Thr Lys Glu Glu 
1               5                   10                  15      


Asn Gln Ser Val Val Val Asp Phe Leu Leu Pro Thr Gly Val Tyr Leu 
            20                  25                  30          


Asn Phe Pro Val Ser Arg Asn Ala Asn Leu Ser Thr Ile Lys Gln Leu 
        35                  40                  45              


Leu Trp His Arg Ala Gln Tyr Glu Pro Leu Phe His Met Leu Ser Gly 
    50                  55                  60                  


Pro Glu Ala Tyr Val Phe Thr Cys Ile Asn Gln Thr Ala Glu Gln Gln 
65                  70                  75                  80  


Glu Leu Glu Asp Glu Gln Arg Arg Leu Cys Asp Val Gln Pro Phe Leu 
                85                  90                  95      


Pro Val Leu Arg Leu Val Ala Arg Glu Gly Asp Arg Val Lys Lys Leu 
            100                 105                 110         


Ile Asn Ser Gln Ile Ser Leu Leu Ile Gly Lys Gly Leu His Glu Phe 
        115                 120                 125             


Asp Ser Leu Cys Asp Pro Glu Val Asn Asp Phe Arg Ala Lys Met Cys 
    130                 135                 140                 


Gln Phe Cys Glu Glu Ala Ala Ala Arg Arg Gln Gln Leu Gly Trp Glu 
145                 150                 155                 160 


Ala Trp Leu Gln Tyr Ser Phe Pro Leu Gln Leu Glu Pro Ser Ala Gln 
                165                 170                 175     


Thr Trp Gly Pro Gly Thr Leu Arg Leu Pro Asn Arg Ala Leu Leu Val 
            180                 185                 190         


Asn Val Lys Phe Glu Gly Ser Glu Glu Ser Phe Thr Phe Gln Val Ser 
        195                 200                 205             


Thr Lys Asp Val Pro Leu Ala Leu Met Ala Cys Ala Leu Arg Lys Lys 
    210                 215                 220                 


Ala Thr Val Phe Arg Gln Pro Leu Val Glu Gln Pro Glu Asp Tyr Thr 
225                 230                 235                 240 


Leu Gln Val Asn Gly Arg His Glu Tyr Leu Tyr Gly Ser Tyr Pro Leu 
                245                 250                 255     


Cys Gln Phe Gln Tyr Ile Cys Ser Cys Leu His Ser Gly Leu Thr Pro 
            260                 265                 270         


His Leu Thr Met Val His Ser Ser Ser Ile Leu Ala Met Arg Asp Glu 
        275                 280                 285             


Gln Ser Asn Pro Ala Pro Gln Val Gln Lys Pro Arg Ala Lys Pro Pro 
    290                 295                 300                 


Pro Ile Pro Ala Lys Lys Pro Ser Ser Val Ser Leu Trp Ser Leu Glu 
305                 310                 315                 320 


Gln Pro Phe Arg Ile Glu Leu Ile Gln Gly Ser Lys Val Asn Ala Asp 
                325                 330                 335     


Glu Arg Met Lys Leu Val Val Gln Ala Gly Leu Phe His Gly Asn Glu 
            340                 345                 350         


Met Leu Cys Lys Thr Val Ser Ser Ser Glu Val Ser Val Cys Ser Glu 
        355                 360                 365             


Pro Val Trp Lys Gln Arg Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu 
    370                 375                 380                 


Pro Arg Met Ala Arg Leu Cys Phe Ala Leu Tyr Ala Val Ile Glu Lys 
385                 390                 395                 400 


Ala Lys Lys Ala Arg Ser Thr Lys Lys Lys Ser Lys Lys Ala Asp Cys 
                405                 410                 415     


Pro Ile Ala Trp Ala Asn Leu Met Leu Phe Asp Tyr Lys Asp Gln Leu 
            420                 425                 430         


Lys Thr Gly Glu Arg Cys Leu Tyr Met Trp Pro Ser Val Pro Asp Glu 
        435                 440                 445             


Lys Gly Glu Leu Leu Asn Pro Thr Gly Thr Val Arg Ser Asn Pro Asn 
    450                 455                 460                 


Thr Asp Ser Ala Ala Ala Leu Leu Ile Cys Leu Pro Glu Val Ala Pro 
465                 470                 475                 480 


His Pro Val Tyr Tyr Pro Ala Leu Glu Lys Ile Leu Glu Leu Gly Arg 
                485                 490                 495     


His Ser Glu Cys Val His Val Thr Glu Glu Glu Gln Leu Gln Leu Arg 
            500                 505                 510         


Glu Ile Leu Glu Arg Arg Gly Ser Gly Glu Leu Tyr Glu His Glu Lys 
        515                 520                 525             


Asp Leu Val Trp Lys Leu Arg His Glu Val Gln Glu His Phe Pro Glu 
    530                 535                 540                 


Ala Leu Ala Arg Leu Leu Leu Val Thr Lys Trp Asn Lys His Glu Asp 
545                 550                 555                 560 


Val Ala Gln Met Leu Tyr Leu Leu Cys Ser Trp Pro Glu Leu Pro Val 
                565                 570                 575     


Leu Ser Ala Leu Glu Leu Leu Asp Phe Ser Phe Pro Asp Cys His Val 
            580                 585                 590         


Gly Ser Phe Ala Ile Lys Ser Leu Arg Lys Leu Thr Asp Asp Glu Leu 
        595                 600                 605             


Phe Gln Tyr Leu Leu Gln Leu Val Gln Val Leu Lys Tyr Glu Ser Tyr 
    610                 615                 620                 


Leu Asp Cys Glu Leu Thr Lys Phe Leu Leu Asp Arg Ala Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Ile Gly His Phe Leu Phe Trp His Leu Arg Ser Glu Met His 
                645                 650                 655     


Val Pro Ser Val Ala Leu Arg Phe Gly Leu Ile Leu Glu Ala Tyr Cys 
            660                 665                 670         


Arg Gly Ser Thr His His Met Lys Val Leu Met Lys Gln Gly Glu Ala 
        675                 680                 685             


Leu Ser Lys Leu Lys Ala Leu Asn Asp Phe Val Lys Leu Ser Ser Gln 
    690                 695                 700                 


Lys Thr Pro Lys Pro Gln Thr Lys Glu Leu Met His Leu Cys Met Arg 
705                 710                 715                 720 


Gln Glu Ala Tyr Leu Glu Ala Leu Ser His Leu Gln Ser Pro Leu Asp 
                725                 730                 735     


Pro Ser Thr Leu Leu Ala Glu Val Cys Val Glu Gln Cys Thr Phe Met 
            740                 745                 750         


Asp Ser Lys Met Lys Pro Leu Trp Ile Met Tyr Ser Asn Glu Glu Ala 
        755                 760                 765             


Gly Ser Gly Gly Ser Val Gly Ile Ile Phe Lys Asn Gly Asp Asp Leu 
    770                 775                 780                 


Arg Gln Asp Met Leu Thr Leu Gln Met Ile Gln Leu Met Asp Val Leu 
785                 790                 795                 800 


Trp Lys Gln Glu Gly Leu Asp Leu Arg Met Thr Pro Tyr Gly Cys Leu 
                805                 810                 815     


Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu Val Val Leu Arg Ser Asp 
            820                 825                 830         


Thr Ile Ala Asn Ile Gln Leu Asn Lys Ser Asn Met Ala Ala Thr Ala 
        835                 840                 845             


Ala Phe Asn Lys Asp Ala Leu Leu Asn Trp Leu Lys Ser Lys Asn Pro 
    850                 855                 860                 


Gly Glu Ala Leu Asp Arg Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala 
865                 870                 875                 880 


Gly Tyr Cys Val Ala Thr Tyr Val Leu Gly Ile Gly Asp Arg His Ser 
                885                 890                 895     


Asp Asn Ile Met Ile Arg Glu Ser Gly Gln Leu Phe His Ile Asp Phe 
            900                 905                 910         


Gly His Phe Leu Gly Asn Phe Lys Thr Lys Phe Gly Ile Asn Arg Glu 
        915                 920                 925             


Arg Val Pro Phe Ile Leu Thr Tyr Asp Phe Val His Val Ile Gln Gln 
    930                 935                 940                 


Gly Lys Thr Asn Asn Ser Glu Lys Phe Glu Arg Phe Arg Gly Tyr Cys 
945                 950                 955                 960 


Glu Arg Ala Tyr Thr Ile Leu Arg Arg His Gly Leu Leu Phe Leu His 
                965                 970                 975     


Leu Phe Ala Leu Met Arg Ala Ala Gly Leu Pro Glu Leu Ser Cys Ser 
            980                 985                 990         


Lys Asp Ile Gln Tyr Leu Lys Asp Ser Leu Ala Leu Gly Lys Thr Glu 
        995                 1000                1005            


Glu Glu Ala Leu Lys His Phe Arg Val Lys Phe Asn Glu Ala Leu Arg 
    1010                1015                1020                


Glu Ser Trp Lys Thr Lys Val Asn Trp Leu Ala His Asn Val Ser Lys 
1025                1030                1035                1040


Asp Asn Arg Gln 
                


<210>  9187
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAI32920

<400>  9187
augcccccug ggguggacug ccccauggaa uucuggacca aggaggagaa ucagagcguu       60

gugguugacu uccugcugcc cacagggguc uaccugaacu ucccuguguc ccgcaaugcc      120

aaccucagca ccaucaagca gcugcugugg caccgcgccc aguaugagcc gcucuuccac      180

augcucagug gccccgaggc cuauguguuc accugcauca accagacagc ggagcagcaa      240

gagcuggagg acgagcaacg gcgucugugu gacgugcagc ccuuccugcc cguccugcgc      300

cugguggccc gugagggcga ccgcgugaag aagcucauca acucacagau cagccuccuc      360

aucggcaaag gccuccacga guuugacucc uugugcgacc cagaagugaa cgacuuucgc      420

gccaagaugu gccaauucug cgaggaggcg gccgcccgcc ggcagcagcu gggcugggag      480

gccuggcugc aguacaguuu cccccugcag cuggagcccu cggcucaaac cugggggccu      540

gguacccugc ggcucccgaa ccgggcccuu cuggucaacg uuaaguuuga gggcagcgag      600

gagagcuuca ccuuccaggu guccaccaag gacgugccgc uggcgcugau ggccugugcc      660

cugcggaaga aggccacagu guuccggcag ccgcuggugg agcagccgga agacuacacg      720

cugcagguga acggcaggca ugaguaccug uauggcagcu acccgcucug ccaguuccag      780

uacaucugca gcugccugca caguggguug accccucacc ugaccauggu ccauuccucc      840

uccauccucg ccaugcggga ugagcagagc aacccugccc cccaggucca gaaaccgcgu      900

gccaaaccac cucccauucc ugcgaagaag ccuuccucug ugucccugug gucccuggag      960

cagccguucc gcaucgagcu cauccagggc agcaaaguga acgccgacga gcggaugaag     1020

cugguggugc aggccgggcu uuuccacggc aacgagaugc ugugcaagac gguguccagc     1080

ucggagguga gcgugugcuc ggagcccgug uggaagcagc ggcuggaguu cgacaucaac     1140

aucugcgacc ugccccgcau ggcccgucuc ugcuuugcgc uguacgccgu gaucgagaaa     1200

gccaagaagg cucgcuccac caagaagaag uccaagaagg cggacugccc cauugccugg     1260

gccaaccuca ugcuguuuga cuacaaggac cagcuuaaga ccggggaacg cugccucuac     1320

auguggcccu ccgucccaga ugagaagggc gagcugcuga accccacggg cacugugcgc     1380

aguaacccca acacggauag cgccgcugcc cugcucaucu gccugcccga gguggccccg     1440

caccccgugu acuaccccgc ccuggagaag aucuuggagc uggggcgaca cagcgagugu     1500

gugcauguca ccgaggagga gcagcugcag cugcgggaaa uccuggagcg gcgggggucu     1560

ggggagcugu augagcacga gaaggaccug guguggaagc ugcggcauga aguccaggag     1620

cacuucccgg aggcgcuagc ccggcugcug cuggucacca aguggaacaa gcaugaggau     1680

guggcccaga ugcucuaccu gcugugcucc uggccggagc ugcccguccu gagcgcccug     1740

gagcugcuag acuucagcuu ccccgauugc cacguaggcu ccuucgccau caagucgcug     1800

cggaaacuga cggacgauga gcuguuccag uaccugcugc agcuggugca ggugcucaag     1860

uacgaguccu accuggacug cgagcugacc aaauuccugc uggaccgggc ccuggccaac     1920

cgcaagaucg gccacuuccu uuucuggcac cuccgcuccg agaugcacgu gccgucggug     1980

gcccugcgcu ucggccucau ccuggaggcc uacugcaggg gcagcaccca ccacaugaag     2040

gugcugauga agcaggggga agcacugagc aaacugaagg cccugaauga cuucgucaag     2100

cugagcucuc agaagacccc caagccccag accaaggagc ugaugcacuu gugcaugcgg     2160

caggaggccu accuagaggc ccucucccac cugcaguccc cacucgaccc cagcacccug     2220

cuggcugaag ucugcgugga gcagugcacc uucauggacu ccaagaugaa gccccugugg     2280

aucauguaca gcaacgagga ggcaggcagc ggcggcagcg ugggcaucau cuuuaagaac     2340

ggggaugacc uccggcagga caugcugacc cugcagauga uccagcucau ggacguccug     2400

uggaagcagg aggggcugga ccugaggaug acccccuaug gcugccuccc caccggggac     2460

cgcacaggcc ucauugaggu gguacuccgu ucagacacca ucgccaacau ccaacucaac     2520

aagagcaaca uggcagccac agccgccuuc aacaaggaug cccugcucaa cuggcugaag     2580

uccaagaacc cgggggaggc ccuggaucga gccauugagg aguucacccu cuccugugcu     2640

ggcuauugug uggccacaua ugugcugggc auuggcgauc ggcacagcga caacaucaug     2700

auccgagaga gugggcagcu guuccacauu gauuuuggcc acuuucuggg gaauuucaag     2760

accaaguuug gaaucaaccg cgagcguguc ccauucaucc ucaccuacga cuuuguccau     2820

gugauucagc aggggaagac uaauaauagu gagaaauuug aacgguuccg gggcuacugu     2880

gaaagggccu acaccauccu gcggcgccac gggcuucucu uccuccaccu cuuugcccug     2940

augcgggcgg caggccugcc ugagcucagc ugcuccaaag acauccagua ucucaaggac     3000

ucccuggcac uggggaaaac agaggaggag gcacugaagc acuuccgagu gaaguuuaac     3060

gaagcccucc gugagagcug gaaaaccaaa gugaacuggc uggcccacaa cguguccaaa     3120

gacaacaggc aguag                                                      3135


<210>  9188
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAI32920

<400>  9188
augcccccgg gcguggacug ccccauggag uucuggacca aggaggagaa ccagagcguc       60

gugguggacu uccugcuccc caccgggguc uaccugaacu uccccguguc ccgcaacgcc      120

aaccugagca cgaucaagca gcuccugugg caccgggccc aguacgagcc gcuguuccac      180

augcucuccg gccccgaggc guacguguuc acgugcauca accagaccgc cgagcagcag      240

gagcuggagg acgagcagcg ccggcugugc gacguccagc ccuuccuccc cgugcugcgc      300

cugguggccc gggaggggga ccgcgucaag aagcucauca acagccagau cucccugcug      360

aucggcaagg ggcuccacga guucgacagc cugugcgacc cggaggugaa cgacuuccgg      420

gccaagaugu gccaguucug cgaggaggcc gcggcccgcc ggcagcagcu gggcugggag      480

gccuggcucc aguacuccuu cccccugcag cuggagccca gcgcccagac cuggggcccc      540

gggacccucc gccugccgaa ccgggcgcug cucgugaacg ucaaguucga gggcuccgag      600

gagagcuuca ccuuccaggu guccaccaag gacgugcccc uggcccugau ggccugcgcc      660

cuccgcaaga aggccaccgu cuuccggcag ccccuggugg agcagcccga ggacuacacg      720

cuccagguga acgggcgcca cgaguaccuc uacggcagcu acccgcugug ccaguuccag      780

uacaucugcu ccugccugca cagcgggcuc acgccccacc ugaccauggu ccacuccagc      840

uccauccugg cgaugcggga cgagcagagc aaccccgcgc cccaggugca gaagccgcgc      900

gccaagcccc cgcccauccc cgccaagaag cccuccagcg ugagccucug gucccuggag      960

cagcccuucc ggaucgagcu gauccagggc agcaagguca acgccgacga gcgcaugaag     1020

cucguggugc aggccggccu guuccacggg aacgagaugc ugugcaagac cgucuccagc     1080

uccgagguga gcgucugcuc cgagcccgug uggaagcagc ggcucgaguu cgacaucaac     1140

aucugcgacc ugccgcgcau ggcccggcug ugcuucgccc ucuacgccgu gaucgagaag     1200

gccaagaagg cgcgcagcac caagaagaag uccaagaagg ccgacugccc caucgccugg     1260

gccaaccuga ugcuguucga cuacaaggac cagcucaaga ccggcgagcg cugccuguac     1320

auguggccca gcgucccgga cgagaagggg gagcugcuga accccaccgg caccgugcgg     1380

uccaacccca acacggacag cgccgcggcc cuccugaucu gccugcccga gguggccccg     1440

caccccgucu acuaccccgc ccucgagaag auccuggagc ugggccgcca cuccgagugc     1500

gugcacguga ccgaggagga gcagcuccag cugcgggaga uccuggagcg ccgggggagc     1560

ggcgagcucu acgagcacga gaaggaccug gucuggaagc ugcgccacga ggugcaggag     1620

cacuuccccg aggcgcucgc ccggcugcug cucgugacca aguggaacaa gcacgaggac     1680

gucgcccaga ugcuguaccu gcucugcucc uggccggagc ugcccgugcu gagcgcccuc     1740

gagcugcugg acuucuccuu ccccgacugc cacgugggga gcuucgccau caagucccuc     1800

cgcaagcuga ccgacgacga gcuguuccag uaccuccugc agcuggucca ggugcucaag     1860

uacgagagcu accuggacug cgagcugacg aaguuccucc uggaccgggc gcuggccaac     1920

cgcaagaucg gccacuuccu cuucuggcac cuccggagcg agaugcacgu gcccuccguc     1980

gcccugcgcu ucgggcugau ccuggaggcc uacugccggg gcagcaccca ccacaugaag     2040

gugcugauga agcagggcga ggcccucucc aagcugaagg cgcugaacga cuucgugaag     2100

cucagcuccc agaagacccc gaagccccag accaaggagc ugaugcaccu gugcaugcgc     2160

caggaggccu accucgaggc ccugagccac cuccagagcc cccuggaccc cuccacgcug     2220

cuggccgagg ucugcgugga gcagugcacc uucauggacu ccaagaugaa gccgcucugg     2280

aucauguaca gcaacgagga ggccgggucc ggcgggagcg ugggcaucau cuucaagaac     2340

ggggacgacc ugcggcagga caugcugacc cuccagauga uccagcugau ggacguccug     2400

uggaagcagg agggccucga ccugcgcaug acccccuacg gcugccugcc cacgggggac     2460

cggaccggcc ucaucgaggu ggugcugcgc uccgacacca ucgcgaacau ccagcugaac     2520

aagagcaaca uggccgccac cgccgcguuc aacaaggacg cccuccugaa cuggcugaag     2580

uccaagaacc ccggggaggc ccucgaccgg gccaucgagg aguucacgcu gagcugcgcc     2640

ggcuacugcg ucgcgaccua cgugcugggg aucggcgacc gccacuccga caacaucaug     2700

auccgcgaga gcggccagcu guuccacauc gacuucgggc acuuccuggg caacuucaag     2760

accaaguucg ggaucaaccg ggagcgcgug ccguucaucc ugaccuacga cuucguccac     2820

gugauccagc agggcaagac gaacaacagc gagaaguucg agcgguuccg cggcuacugc     2880

gagcgggccu acaccauccu ccgccggcac gggcugcugu uccuccaccu guucgcccug     2940

augcgcgccg ccggccuccc cgagcugucc ugcagcaagg acauccagua ccugaaggac     3000

ucccucgcgc uggggaagac cgaggaggag gcccugaagc acuuccgggu gaaguucaac     3060

gaggcccucc gcgagagcug gaagaccaag gucaacuggc uggcccacaa cguguccaag     3120

gacaaccggc aguga                                                      3135


<210>  9189
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAI32920

<400>  9189
augccccccg gcgucgacug ccccauggag uucuggacca aggaggagaa ccaguccguc       60

gucgucgacu uccuccuccc caccggcguc uaccucaacu uccccgucuc ccgcaacgcc      120

aaccucucca ccaucaagca gcuccucugg caccgcgccc aguacgagcc ccucuuccac      180

augcucuccg gccccgaggc cuacgucuuc accugcauca accagaccgc cgagcagcag      240

gagcucgagg acgagcagcg ccgccucugc gacguccagc ccuuccuccc cguccuccgc      300

cucgucgccc gcgagggcga ccgcgucaag aagcucauca acucccagau cucccuccuc      360

aucggcaagg gccuccacga guucgacucc cucugcgacc ccgaggucaa cgacuuccgc      420

gccaagaugu gccaguucug cgaggaggcc gccgcccgcc gccagcagcu cggcugggag      480

gccuggcucc aguacuccuu cccccuccag cucgagcccu ccgcccagac cuggggcccc      540

ggcacccucc gccuccccaa ccgcgcccuc cucgucaacg ucaaguucga gggcuccgag      600

gaguccuuca ccuuccaggu cuccaccaag gacguccccc ucgcccucau ggccugcgcc      660

cuccgcaaga aggccaccgu cuuccgccag ccccucgucg agcagcccga ggacuacacc      720

cuccagguca acggccgcca cgaguaccuc uacggcuccu acccccucug ccaguuccag      780

uacaucugcu ccugccucca cuccggccuc accccccacc ucaccauggu ccacuccucc      840

uccauccucg ccaugcgcga cgagcagucc aaccccgccc cccaggucca gaagccccgc      900

gccaagcccc cccccauccc cgccaagaag cccuccuccg ucucccucug gucccucgag      960

cagcccuucc gcaucgagcu cauccagggc uccaagguca acgccgacga gcgcaugaag     1020

cucgucgucc aggccggccu cuuccacggc aacgagaugc ucugcaagac cgucuccucc     1080

uccgaggucu ccgucugcuc cgagcccguc uggaagcagc gccucgaguu cgacaucaac     1140

aucugcgacc ucccccgcau ggcccgccuc ugcuucgccc ucuacgccgu caucgagaag     1200

gccaagaagg cccgcuccac caagaagaag uccaagaagg ccgacugccc caucgccugg     1260

gccaaccuca ugcucuucga cuacaaggac cagcucaaga ccggcgagcg cugccucuac     1320

auguggcccu ccguccccga cgagaagggc gagcuccuca accccaccgg caccguccgc     1380

uccaacccca acaccgacuc cgccgccgcc cuccucaucu gccuccccga ggucgccccc     1440

caccccgucu acuaccccgc ccucgagaag auccucgagc ucggccgcca cuccgagugc     1500

guccacguca ccgaggagga gcagcuccag cuccgcgaga uccucgagcg ccgcggcucc     1560

ggcgagcucu acgagcacga gaaggaccuc gucuggaagc uccgccacga gguccaggag     1620

cacuuccccg aggcccucgc ccgccuccuc cucgucacca aguggaacaa gcacgaggac     1680

gucgcccaga ugcucuaccu ccucugcucc uggcccgagc uccccguccu cuccgcccuc     1740

gagcuccucg acuucuccuu ccccgacugc cacgucggcu ccuucgccau caagucccuc     1800

cgcaagcuca ccgacgacga gcucuuccag uaccuccucc agcucgucca gguccucaag     1860

uacgaguccu accucgacug cgagcucacc aaguuccucc ucgaccgcgc ccucgccaac     1920

cgcaagaucg gccacuuccu cuucuggcac cuccgcuccg agaugcacgu ccccuccguc     1980

gcccuccgcu ucggccucau ccucgaggcc uacugccgcg gcuccaccca ccacaugaag     2040

guccucauga agcagggcga ggcccucucc aagcucaagg cccucaacga cuucgucaag     2100

cucuccuccc agaagacccc caagccccag accaaggagc ucaugcaccu cugcaugcgc     2160

caggaggccu accucgaggc ccucucccac cuccaguccc cccucgaccc cuccacccuc     2220

cucgccgagg ucugcgucga gcagugcacc uucauggacu ccaagaugaa gccccucugg     2280

aucauguacu ccaacgagga ggccggcucc ggcggcuccg ucggcaucau cuucaagaac     2340

ggcgacgacc uccgccagga caugcucacc cuccagauga uccagcucau ggacguccuc     2400

uggaagcagg agggccucga ccuccgcaug acccccuacg gcugccuccc caccggcgac     2460

cgcaccggcc ucaucgaggu cguccuccgc uccgacacca ucgccaacau ccagcucaac     2520

aaguccaaca uggccgccac cgccgccuuc aacaaggacg cccuccucaa cuggcucaag     2580

uccaagaacc ccggcgaggc ccucgaccgc gccaucgagg aguucacccu cuccugcgcc     2640

ggcuacugcg ucgccaccua cguccucggc aucggcgacc gccacuccga caacaucaug     2700

auccgcgagu ccggccagcu cuuccacauc gacuucggcc acuuccucgg caacuucaag     2760

accaaguucg gcaucaaccg cgagcgcguc cccuucaucc ucaccuacga cuucguccac     2820

gucauccagc agggcaagac caacaacucc gagaaguucg agcgcuuccg cggcuacugc     2880

gagcgcgccu acaccauccu ccgccgccac ggccuccucu uccuccaccu cuucgcccuc     2940

augcgcgccg ccggccuccc cgagcucucc ugcuccaagg acauccagua ccucaaggac     3000

ucccucgccc ucggcaagac cgaggaggag gcccucaagc acuuccgcgu caaguucaac     3060

gaggcccucc gcgaguccug gaagaccaag gucaacuggc ucgcccacaa cgucuccaag     3120

gacaaccgcc aguga                                                      3135


<210>  9190
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAI32920

<400>  9190
augcccccug gcguggacug cccaauggag uucuggacca aggaagagaa ccagagcguc       60

guuguggauu uucugcuccc gacaggggua uaccuuaauu uccccguguc cagaaacgcc      120

aaucugucua cuaucaaaca auuguuaugg cacagggcuc aguaugaacc ucuguuucau      180

augcuaucag gaccagaggc auacgucuuc acguguauua accagaccgc cgaacagcaa      240

gagcucgagg acgaacagcg gcgccugugc gaugugcagc ccuuucuucc uguucugcga      300

uugguggcgc gugaggguga cagagucaag aaacucauaa auagucagau cagccugcug      360

auuggcaagg ggcuccacga guucgauucc uuaugugacc cagaggugaa cgauuuuagg      420

gcuaaaaugu gccaauucug ugaggaagcc gcagcccggc gccagcagcu gggaugggag      480

gcuuggcuuc aguauucuuu ucccuugcaa cuggaaccuu cggcacagac auggggccca      540

gguacucuaa gacucccgaa uagggcccug cuuguaaacg uuaaguucga ggggucagaa      600

gagagcuuua ccuuccaggu gaguacaaag gacguccccc uggcuuugau ggccugcgcg      660

cuccggaaaa aggcaaccgu guuucgccaa ccucuggugg agcagccaga agauuacacu      720

uuacagguca auggacgaca ugaguaucug uacggcuccu auccccucug ucaguuccaa      780

uacaucugcu cuugucuuca cagcggccug acaccucauu ugaccauggu ucacuccuca      840

aguauucuag ccaugagaga cgaacagagc aacccagcuc cccaggugca gaaaccgagg      900

gccaagccuc ccccaauccc ugcuaaaaag cccucuuccg uaucacugug gagccucgag      960

caaccauucc ggauagaacu gauccagggg aguaagguga augcagauga gcguaugaaa     1020

cuugucgugc aggccggacu guuucacggu aacgagaugu ugugcaagac gguuucuucc     1080

agcgaagugu cggucuguuc ugagcccgug uggaaacagc gccucgaguu cgacauuaau     1140

aucugcgauc ugccuagaau ggcgagguua ugcuuugccc uguacgcagu aauugaaaag     1200

gcuaaaaagg cccgguccac uaaaaagaag aguaaaaagg cugacugucc aaucgccugg     1260

gcaaaccuaa ugcuguucga cuauaaagau caacucaaga ccggcgaacg augccuuuac     1320

auguggccgu caguucccga cgagaaaggg gaguugcuga auccuacagg aacugugcgc     1380

agcaacccaa acaccgauuc cgccgcugcg cuccugauau gucuucccga agucgcaccu     1440

cauccagugu auuaccccgc ccuggagaag auuuuggaac ucggcagaca cucugagugc     1500

guccauguga cagaggaaga acagcugcag uuaagggaaa uccuggagcg gcgcgguagc     1560

ggggaacuau augagcacga gaaggaccuc guuuggaaac ugagacacga agugcaggag     1620

cauuuuccgg aagcucuugc cagguugcug cucguaacca aguggaauaa acacgaggau     1680

gucgcacaaa ugcuguacuu acuguguuca uggccugaac uuccaguguu gagugcccuc     1740

gagcugcuag acuucuccuu ucccgauugc cauguuggca gcuucgcuau uaagucucug     1800

cguaaacuca cggacgauga gcuguuucag uaucuuuugc agcuggugca agucuuaaag     1860

uacgaaucau accucgacug ugagcugacu aaguuccuuc uggaucgggc cuuggcaaac     1920

cgaaaaaucg gacacuuucu cuucuggcau cugagaagug aaaugcacgu gccuagcgua     1980

gcgcuaaggu uuggccugau ccucgaggcu uauugccgcg gguccacaca ccauaugaag     2040

gugcugauga aacagggaga agcccuuucu aaguugaaag cacugaauga cuucguuaag     2100

uuaucgagcc agaagacccc caaaccacag acuaaggagc ucaugcaccu guguaugcgg     2160

caagaggccu accuugaagc ucugucccau cuacagucac cucucgaccc caguacacug     2220

uuggccgagg ucugcgugga acaguguacc uucauggauu cuaaaaugaa gccacugugg     2280

auuauguaua gcaacgagga ggcagguucc ggcgggucag ugggaauaau cuuuaaaaau     2340

ggcgacgauu uaagacagga caugcucacg cugcaaauga uucagcuuau ggauguccug     2400

uggaagcagg aagguuugga ccucaggaug accccguacg ggugccugcc uacaggcgau     2460

cgcacuggac uaaucgaggu ugugcugcga agcgacacca uagcuaacau ucagcuuaau     2520

aaaucuaaca uggccgcgac agccgcuuuc aauaaggaug cacuccugaa cugguugaag     2580

uccaaaaauc ccggcgaagc ccuggaccgg gcuaucgagg aauuuacuuu aaguugcgcc     2640

ggguauugug uggcaaccua cguacucgga aucggugauc gucacagcga caacauuaug     2700

aucagagagu cuggccaacu guuccacauu gauuuugggc auuuccuugg aaauuuuaag     2760

acaaaauucg gcauaaacag ggagcgcguc ccauuuaucc ugaccuauga cuucgugcac     2820

guuauucagc aggguaagac uaauaacucc gaaaaauuug agcgguucag aggguacugc     2880

gaaagggcgu acacgaucuu gcgacgccau ggccuccugu uucuacaccu guucgcccuu     2940

augcgggcug ccggacuccc cgagcuguca uguaguaagg acauccaaua uuugaaggau     3000

agcuuagcac ugggcaaaac agaagaggag gcucucaagc auuucagagu gaaauuuaac     3060

gaagcccuga gggagucgug gaagaccaaa gucaauuggc uugcacacaa cguguccaag     3120

gacaaucguc aguga                                                      3135


<210>  9191
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAI32920

<400>  9191
augccccccg gcguggacug ccccauggag uucuggacca aggaggagaa ccagagcgug       60

gugguggacu uccugcugcc caccggcgug uaccugaacu uccccgugag cagaaacgcc      120

aaccugagca ccaucaagca gcugcugugg cacagagccc aguacgagcc ccuguuccac      180

augcugagcg gccccgaggc cuacguguuc accugcauca accagaccgc cgagcagcag      240

gagcuggagg acgagcagag aagacugugc gacgugcagc ccuuccugcc cgugcugaga      300

cugguggcca gagagggcga cagagugaag aagcugauca acagccagau cagccugcug      360

aucggcaagg gccugcacga guucgacagc cugugcgacc ccgaggugaa cgacuucaga      420

gccaagaugu gccaguucug cgaggaggcc gccgccagaa gacagcagcu gggcugggag      480

gccuggcugc aguacagcuu cccccugcag cuggagccca gcgcccagac cuggggcccc      540

ggcacccuga gacugcccaa cagagcccug cuggugaacg ugaaguucga gggcagcgag      600

gagagcuuca ccuuccaggu gagcaccaag gacgugcccc uggcccugau ggccugcgcc      660

cugagaaaga aggccaccgu guucagacag ccccuggugg agcagcccga ggacuacacc      720

cugcagguga acggcagaca cgaguaccug uacggcagcu acccccugug ccaguuccag      780

uacaucugca gcugccugca cagcggccug accccccacc ugaccauggu gcacagcagc      840

agcauccugg ccaugagaga cgagcagagc aaccccgccc cccaggugca gaagcccaga      900

gccaagcccc cccccauccc cgccaagaag cccagcagcg ugagccugug gagccuggag      960

cagcccuuca gaaucgagcu gauccagggc agcaagguga acgccgacga gagaaugaag     1020

cugguggugc aggccggccu guuccacggc aacgagaugc ugugcaagac cgugagcagc     1080

agcgagguga gcgugugcag cgagcccgug uggaagcaga gacuggaguu cgacaucaac     1140

aucugcgacc ugcccagaau ggccagacug ugcuucgccc uguacgccgu gaucgagaag     1200

gccaagaagg ccagaagcac caagaagaag agcaagaagg ccgacugccc caucgccugg     1260

gccaaccuga ugcuguucga cuacaaggac cagcugaaga ccggcgagag augccuguac     1320

auguggccca gcgugcccga cgagaagggc gagcugcuga accccaccgg caccgugaga     1380

agcaacccca acaccgacag cgccgccgcc cugcugaucu gccugcccga gguggccccc     1440

caccccgugu acuaccccgc ccuggagaag auccuggagc ugggcagaca cagcgagugc     1500

gugcacguga ccgaggagga gcagcugcag cugagagaga uccuggagag aagaggcagc     1560

ggcgagcugu acgagcacga gaaggaccug guguggaagc ugagacacga ggugcaggag     1620

cacuuccccg aggcccuggc cagacugcug cuggugacca aguggaacaa gcacgaggac     1680

guggcccaga ugcuguaccu gcugugcagc uggcccgagc ugcccgugcu gagcgcccug     1740

gagcugcugg acuucagcuu ccccgacugc cacgugggca gcuucgccau caagagccug     1800

agaaagcuga ccgacgacga gcuguuccag uaccugcugc agcuggugca ggugcugaag     1860

uacgagagcu accuggacug cgagcugacc aaguuccugc uggacagagc ccuggccaac     1920

agaaagaucg gccacuuccu guucuggcac cugagaagcg agaugcacgu gcccagcgug     1980

gcccugagau ucggccugau ccuggaggcc uacugcagag gcagcaccca ccacaugaag     2040

gugcugauga agcagggcga ggcccugagc aagcugaagg cccugaacga cuucgugaag     2100

cugagcagcc agaagacccc caagccccag accaaggagc ugaugcaccu gugcaugaga     2160

caggaggccu accuggaggc ccugagccac cugcagagcc cccuggaccc cagcacccug     2220

cuggccgagg ugugcgugga gcagugcacc uucauggaca gcaagaugaa gccccugugg     2280

aucauguaca gcaacgagga ggccggcagc ggcggcagcg ugggcaucau cuucaagaac     2340

ggcgacgacc ugagacagga caugcugacc cugcagauga uccagcugau ggacgugcug     2400

uggaagcagg agggccugga ccugagaaug acccccuacg gcugccugcc caccggcgac     2460

agaaccggcc ugaucgaggu ggugcugaga agcgacacca ucgccaacau ccagcugaac     2520

aagagcaaca uggccgccac cgccgccuuc aacaaggacg cccugcugaa cuggcugaag     2580

agcaagaacc ccggcgaggc ccuggacaga gccaucgagg aguucacccu gagcugcgcc     2640

ggcuacugcg uggccaccua cgugcugggc aucggcgaca gacacagcga caacaucaug     2700

aucagagaga gcggccagcu guuccacauc gacuucggcc acuuccuggg caacuucaag     2760

accaaguucg gcaucaacag agagagagug cccuucaucc ugaccuacga cuucgugcac     2820

gugauccagc agggcaagac caacaacagc gagaaguucg agagauucag aggcuacugc     2880

gagagagccu acaccauccu gagaagacac ggccugcugu uccugcaccu guucgcccug     2940

augagagccg ccggccugcc cgagcugagc ugcagcaagg acauccagua ccugaaggac     3000

agccuggccc ugggcaagac cgaggaggag gcccugaagc acuucagagu gaaguucaac     3060

gaggcccuga gagagagcug gaagaccaag gugaacuggc uggcccacaa cgugagcaag     3120

gacaacagac aguga                                                      3135


<210>  9192
<211>  3135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAI32920

<400>  9192
augcccccug gcguggacug cccgauggag uucuggacca aggaagagaa ccagagcguc       60

guuguggauu uucugcuccc cacaggggug uaccugaauu ucccugucuc cagaaacgcc      120

aaucuuucua cgaucaaaca acugcucugg caccgggcuc aguaugaacc ccuguuucau      180

augcuuagcg gaccugaggc cuacguguuc accuguauua accagacagc ggaacagcaa      240

gagcuggagg acgaacagcg cagacucugc gauguucagc ccuuucugcc ugugcugcgg      300

cucgucgcuc gcgagggcga cagagugaag aaacugauca auucccagau uucucuucug      360

aucgggaagg gacuccacga guucgauagc cugugugacc cggagguuaa cgauuuucgg      420

gccaaaaugu gccaauucug ugaggaagcc gcugcccgca gacagcagcu uggcugggag      480

gcuuggcugc aguauuccuu uccccuccaa cuggaaccuu cugcccagac cugggggccc      540

ggaacacugc ggcucccuaa ucgcgcgcug cuugugaacg ucaaguucga gggcagcgaa      600

gaguccuuua ccuuccaggu gagcacaaag gacgugcccc uggcccucau ggcuugcgcc      660

cugagaaaga aggcuaccgu cuuucggcaa ccgcuuguug agcagccuga agauuacacg      720

cuccagguga auggccgcca ugaguaucug uacgggucuu auccccugug ucaguuccaa      780

uacauuugcu ccugucugca cagcggacuc accccucauc ugacaauggu gcacucuucc      840

agcauccuug ccaugagaga cgaacagucu aaccccgcgc cccaggucca gaaaccucgg      900

gccaagccgc ccccuauccc cgcuaaaaag ccuuccagcg ugucccugug gucucucgag      960

caacccuucc gcauugaacu gauccagggc agcaagguua augccgauga gagaaugaaa     1020

cuuguggucc aggcugggcu guuucacgga aacgagaugc ucugcaagac cguguccagc     1080

ucugaaguuu ccguguguag cgagccgguc uggaaacagc ggcuggaguu cgacauuaau     1140

aucugcgauc ugccuagaau ggcccgccuc ugcuuugccc uguacgcugu gauugaaaag     1200

gcgaaaaagg cccggucuac aaagaaaaag agcaaaaagg cugacugucc caucgccugg     1260

gccaaccuua ugcuguucga cuauaaagau caacucaaga ccggcgaaag augccuguac     1320

auguggccuu ccguccccga cgagaaaggg gagcugcuua auccuacggg aacagugcgc     1380

ucuaacccca acaccgauag cgcugccgcg cuccugauuu gucugccgga aguugcuccu     1440

caucccgugu auuaccccgc ccucgagaag auccuggaac uuggccggca cuccgagugc     1500

guccauguga cagaggaaga acagcugcag cucagagaaa uccuggagcg ccggggcagc     1560

ggggaacugu augagcacga gaaggaccuu guuuggaaac ucagacacga agugcaggag     1620

cauuuuccug aagcccuggc ucgccugcuc cuggucacca aguggaauaa acacgaggau     1680

guggcccaaa ugcuuuaccu gcucuguucu uggccggaac ugcccgugcu guccgcucuu     1740

gagcuccugg acuucagcuu uccugauugc cauguuggau cuuucgccau uaagucccug     1800

cggaaacuca ccgacgauga gcuguuucag uaucuucugc agcucgucca agugcugaag     1860

uacgaaagcu accuggacug ugagcuuaca aaguuccucc uggauagagc gcuggccaac     1920

cgcaaaaucg gccacuuucu cuucuggcau cugcgguccg aaaugcacgu gcccucuguc     1980

gcucuuagau uugggcugau ucucgaggcc uauugccggg gaagcacgca ccauaugaag     2040

gugcugauga aacagggcga agcucugucc aaacuuaaag cccugaauga cuucguuaag     2100

cucucuagcc agaagacccc uaaaccccag acaaaggagc ugaugcaccu cuguaugcgc     2160

caagaggcgu accuggaagc ccuuucccau cugcagagcc cucucgaccc cucuacccug     2220

cuggcugagg ugugcgucga acaguguaca uucauggauu ccaaaaugaa gccgcuuugg     2280

aucauguaua gcaacgagga ggccgggucu ggaggcuccg ugggcauuau cuuuaaaaau     2340

ggggacgauc ugagacagga caugcucacc cugcaaauga uccagcucau ggauguucug     2400

uggaagcagg aaggacuuga ccugcggaug acgccuuacg gcugccuccc cacaggggau     2460

agaaccggac ugauugaggu gguccugcgc agcgacacca ucgcuaacau ucagcuuaau     2520

aaaucuaaca uggccgccac agcugcguuc aauaaggaug cccugcucaa cuggcucaag     2580

agcaaaaauc cuggcgaagc ucuggaccgg gccaucgagg aauuuacccu guccugcgcc     2640

ggguauugug uggcuacaua cguucuuggc auuggagaua gacacagcga caacaucaug     2700

auccgcgagu cuggccaacu guuccacauu gauuuugggc auuuccuggg aaauuuuaag     2760

acgaaauucg gcaucaacag agagcgggug cccuuuauuc ucaccuauga cuucguccac     2820

gugauccagc aggggaagac aaauaacucc gaaaaauuug agcgcuucag aggauacugc     2880

gaacgggccu acaccauucu gcgcagacau ggccuucugu uucuccaccu guucgcgcuc     2940

augcgggcug ccgggcugcc ggagcuuagc uguuccaagg acauccaaua ucugaaggau     3000

ucucuggccc ucggcaaaac agaagaggag gcucugaagc auuuccgcgu gaaauuuaac     3060

gaagcccuua gagagagcug gaagaccaaa gucaauuggc uggcgcacaa cguuuccaag     3120

gacaaucggc aguga                                                      3135


<210>  9193
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__O00459

<400>  9193

Met Ala Gly Pro Glu Gly Phe Gln Tyr Arg Ala Leu Tyr Pro Phe Arg 
1               5                   10                  15      


Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Val Leu Val 
            20                  25                  30          


Val Ser Arg Ala Ala Leu Gln Ala Leu Gly Val Ala Glu Gly Gly Glu 
        35                  40                  45              


Arg Cys Pro Gln Ser Val Gly Trp Met Pro Gly Leu Asn Glu Arg Thr 
    50                  55                  60                  


Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
65                  70                  75                  80  


Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                85                  90                  95      


Pro Ala Arg Pro Arg Asp Gly Ala Pro Glu Pro Gly Leu Thr Leu Pro 
            100                 105                 110         


Asp Leu Pro Glu Gln Phe Ser Pro Pro Asp Val Ala Pro Pro Leu Leu 
        115                 120                 125             


Val Lys Leu Val Glu Ala Ile Glu Arg Thr Gly Leu Asp Ser Glu Ser 
    130                 135                 140                 


His Tyr Arg Pro Glu Leu Pro Ala Pro Arg Thr Asp Trp Ser Leu Ser 
145                 150                 155                 160 


Asp Val Asp Gln Trp Asp Thr Ala Ala Leu Ala Asp Gly Ile Lys Ser 
                165                 170                 175     


Phe Leu Leu Ala Leu Pro Ala Pro Leu Val Thr Pro Glu Ala Ser Ala 
            180                 185                 190         


Glu Ala Arg Arg Ala Leu Arg Glu Ala Ala Gly Pro Val Gly Pro Ala 
        195                 200                 205             


Leu Glu Pro Pro Thr Leu Pro Leu His Arg Ala Leu Thr Leu Arg Phe 
    210                 215                 220                 


Leu Leu Gln His Leu Gly Arg Val Ala Ser Arg Ala Pro Ala Leu Gly 
225                 230                 235                 240 


Pro Ala Val Arg Ala Leu Gly Ala Thr Phe Gly Pro Leu Leu Leu Arg 
                245                 250                 255     


Ala Pro Pro Pro Pro Ser Ser Pro Pro Pro Gly Gly Ala Pro Asp Gly 
            260                 265                 270         


Ser Glu Pro Ser Pro Asp Phe Pro Ala Leu Leu Val Glu Lys Leu Leu 
        275                 280                 285             


Gln Glu His Leu Glu Glu Gln Glu Val Ala Pro Pro Ala Leu Pro Pro 
    290                 295                 300                 


Lys Pro Pro Lys Ala Lys Pro Ala Ser Thr Val Leu Ala Asn Gly Gly 
305                 310                 315                 320 


Ser Pro Pro Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser 
                325                 330                 335     


Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Pro Asp Gly Thr Phe 
            340                 345                 350         


Leu Val Arg Asp Ala Ser Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr 
        355                 360                 365             


Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Val Phe His Arg Asp 
    370                 375                 380                 


Gly His Tyr Gly Phe Ser Glu Pro Leu Thr Phe Cys Ser Val Val Asp 
385                 390                 395                 400 


Leu Ile Asn His Tyr Arg His Glu Ser Leu Ala Gln Tyr Asn Ala Lys 
                405                 410                 415     


Leu Asp Thr Arg Leu Leu Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln 
            420                 425                 430         


Ile Val Lys Glu Asp Ser Val Glu Ala Val Gly Ala Gln Leu Lys Val 
        435                 440                 445             


Tyr His Gln Gln Tyr Gln Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr 
    450                 455                 460                 


Glu Glu Tyr Thr Arg Thr Ser Gln Glu Leu Gln Met Lys Arg Thr Ala 
465                 470                 475                 480 


Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu Gln Gly Gln 
                485                 490                 495     


Thr Gln Glu Lys Cys Ser Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu 
            500                 505                 510         


Gly Asn Glu Lys Glu Met Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu 
        515                 520                 525             


Lys Ser Arg Ile Ala Glu Ile His Glu Ser Arg Thr Lys Leu Glu Gln 
    530                 535                 540                 


Gln Leu Arg Ala Gln Ala Ser Asp Asn Arg Glu Ile Asp Lys Arg Met 
545                 550                 555                 560 


Asn Ser Leu Lys Pro Asp Leu Met Gln Leu Arg Lys Ile Arg Asp Gln 
                565                 570                 575     


Tyr Leu Val Trp Leu Thr Gln Lys Gly Ala Arg Gln Lys Lys Ile Asn 
            580                 585                 590         


Glu Trp Leu Gly Ile Lys Asn Glu Thr Glu Asp Gln Tyr Ala Leu Met 
        595                 600                 605             


Glu Asp Glu Asp Asp Leu Pro His His Glu Glu Arg Thr Trp Tyr Val 
    610                 615                 620                 


Gly Lys Ile Asn Arg Thr Gln Ala Glu Glu Met Leu Ser Gly Lys Arg 
625                 630                 635                 640 


Asp Gly Thr Phe Leu Ile Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala 
                645                 650                 655     


Cys Ser Val Val Val Asp Gly Asp Thr Lys His Cys Val Ile Tyr Arg 
            660                 665                 670         


Thr Ala Thr Gly Phe Gly Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser 
        675                 680                 685             


Leu Lys Glu Leu Val Leu His Tyr Gln His Ala Ser Leu Val Gln His 
    690                 695                 700                 


Asn Asp Ala Leu Thr Val Thr Leu Ala His Pro Val Arg Ala Pro Gly 
705                 710                 715                 720 


Pro Gly Pro Pro Pro Ala Ala Arg 
                725             


<210>  9194
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAD22671

<400>  9194
auggcgggcc cugagggcuu ccaguaccgc gcucuguacc cguuccgccg ggagcggccg       60

gaggaccugg agcugcugcc cggcgacgug cugguaguga gccgggcggc cuugcaggcg      120

cugggcgugg ccgagggugg cgagcgcugc ccacagagcg ugggcuggau gcccggccuc      180

aacgagcgca cacggcagcg aggugacuuc ccuggcaccu auguggaguu ccuggggccc      240

guggcccugg cccggcccgg cccucgccca cggggccccc gcccacugcc cgccaggccc      300

cgugaugggg ccccugagcc aggccucaca cuccccgacu ugcccgagca guucucccca      360

ccugaugugg cucccccucu ucuggugaag cuuguggagg ccauugaaag gacagggcug      420

gacagcgaau cucacuaccg cccggagcug cccgcaccgc guacagacug gucccugagc      480

gacguggauc agugggacac ggcagcccug gcugacggca uuaagagcuu ccugcuggca      540

cugcccgcgc cgcucgugac ccccgaggcc ucggccgagg cgcgccgggc ccugcgggag      600

gccgcggggc ccguggggcc ggcgcuggag ccaccgacgc ugccgcugca ccgcgcgcuc      660

acgcugcgcu uccugcucca gcaccugggc cgcguggcca gccgcgcccc ggcccugggu      720

cccgcggucc gggcccuggg cgccaccuuu gggccgcugc ugcugcgcgc gccgccgccg      780

ccguccucgc cgccgccagg gggcgcuccc gacgggagug agcccagccc ugacuucccg      840

gcgcugcugg uggagaagcu gcuucaggaa cacuuggaag agcaggaggu ugcgccccca      900

gcgcugccgc cuaaaccccc caaggcaaag ccggccucca caguccuggc caauggaggg      960

agcccacccu cccugcagga ugcugagugg uacugggggg acauuucaag ggaggaggug     1020

aacgagaaac uccgggacac ucccgauggc accuuccuag uccgagaugc uucuagcaag     1080

auccagggcg aguacacgcu gacccucagg aaaggcggga acaauaagcu gaucaagguc     1140

uuccaccgag augggcacua uggcuucuca gagccacuca ccuucugcuc cguuguggac     1200

cucaucaauc acuaccgcca cgagucucug gcccaguaca augccaagcu ggacacacgg     1260

cuccucuacc cuguguccaa auaccagcag gaccagauug ucaaggagga cagcguggag     1320

gcagugggcg cccagcuuaa ggucuaucac cagcaguacc aggacaagag ccgcgaguau     1380

gaccagcuuu augaagagua cacacggacc ucccaggagc ugcagaugaa gcguacugca     1440

auugaggccu ucaaugagac uaucaagauc uuugaagagc agggccagac ucaagagaaa     1500

ugcagcaagg aauaccugga gcgcuuccgg cgugagggca acgagaaaga gaugcaaagg     1560

auccugcuga acuccgagcg gcucaagucc cgcauugccg agauccauga gagccgcacg     1620

aagcuggagc agcagcugcg ggcccaggcc ucggacaaca gagagaucga caagcgcaug     1680

aacagccuca agccggaccu caugcagcug cgcaagaucc gagaccagua ccucgugugg     1740

cucacccaga aaggcgcccg gcagaagaaa aucaacgagu ggcuggggau uaaaaaugag     1800

acugaggacc aguacgcacu cauggaggac gaggacgauc ucccgcacca cgaggaacgc     1860

acuugguacg ugggcaagau caaccgcacg caggcagagg agaugcugag uggcaagcgg     1920

gauggcaccu uccucauccg cgagagcagc cagcggggcu gcuacgccug cuccguggua     1980

guggacggcg acaccaagca cugcgucauc uaccgcacgg ccaccggcuu cggcuucgcg     2040

gagcccuaca accuguacgg gucgcugaag gagcuggugc ugcacuacca gcacgccucg     2100

cuggugcagc acaacgacgc gcucaccguc acccuggcgc acccagugcg cgccccgggc     2160

cccggcccgc cgccugccgc ccgcuga                                         2187


<210>  9195
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAD22671

<400>  9195
auggccggcc ccgagggguu ccaguaccgc gcccuguacc cguuccggcg cgagcggccc       60

gaggaccucg agcugcugcc cggcgacgug cucgucguga gccgcgcggc ccugcaggcc      120

cugggggugg ccgagggcgg ggagcggugc ccccaguccg ucggcuggau gccgggccuc      180

aacgagcgca cccggcagcg cggggacuuc cccggcaccu acguggaguu ccuggggccc      240

guggcccugg cgcggcccgg cccgcgcccc cgggggcccc gcccccuccc ggcccggccc      300

cgcgacggcg cccccgagcc cggccugacg cugccggacc uccccgagca guucagcccc      360

cccgacgucg ccccgccccu gcuggugaag cucguggagg cgaucgagcg gaccgggcug      420

gacuccgaga gccacuaccg ccccgagcug cccgccccgc ggaccgacug gucccucagc      480

gacgucgacc agugggacac cgccgcccug gccgacggca ucaaguccuu ccugcucgcg      540

cugcccgccc cccuggugac gcccgaggcc agcgccgagg cccgccgggc gcuccgcgag      600

gccgccgggc cggugggccc cgcccuggag cccccgaccc ugccccucca ccgggcccug      660

acccugcgcu uccuccugca gcaccugggc cgcgucgcgu cccgggcccc cgcccucggg      720

cccgccgugc gcgcccuggg cgcgaccuuc gggccgcugc uccugcgggc cccccccccc      780

ccgagcuccc ccccccccgg cggggccccg gacggcagcg agcccucccc cgacuucccc      840

gcccugcucg uggagaagcu gcugcaggag caccucgagg agcaggaggu cgcgccgccc      900

gcccugcccc ccaagccgcc caaggccaag cccgccagca cggugcuggc caacggcggg      960

ucccccccga gccuccagga cgcggagugg uacuggggcg acaucucccg cgaggaggug     1020

aacgagaagc ugcgggacac ccccgacggg accuuccugg uccgcgacgc cagcuccaag     1080

auccagggcg aguacacccu cacgcugcgg aaggggggca acaacaagcu gaucaaggug     1140

uuccaccgcg acggccacua cggguucagc gagccccuga ccuucugcag cguggucgac     1200

cucaucaacc acuaccggca cgagucccug gcccaguaca acgccaagcu ggacacccgc     1260

cuccuguacc cggugagcaa guaccagcag gaccagaucg ugaaggagga cuccgucgag     1320

gccgugggcg cgcagcugaa ggucuaccac cagcaguacc aggacaagag ccgggaguac     1380

gaccagcucu acgaggagua cacccgcacg ucccaggagc ugcagaugaa gcggaccgcc     1440

aucgaggccu ucaacgagac caucaagauc uucgaggagc aggggcagac ccaggagaag     1500

ugcagcaagg aguaccugga gcgcuuccgg cgcgagggca acgagaagga gaugcagcgg     1560

auccuccuga acuccgagcg ccugaagagc cggaucgccg agauccacga gucccgcacg     1620

aagcucgagc agcagcugcg cgcccaggcg agcgacaacc gggagaucga caagcgcaug     1680

aacucccuga agcccgaccu caugcagcug cggaagaucc gcgaccagua ccuggugugg     1740

cucacccaga agggggcccg gcagaagaag aucaacgagu ggcugggcau caagaacgag     1800

accgaggacc aguacgcccu gauggaggac gaggacgacc ucccccacca cgaggagcgc     1860

accugguacg ugggcaagau caaccggacg caggccgagg agaugcugag cgggaagcgc     1920

gacggcaccu uccugauccg ggaguccagc cagcgcgggu gcuacgcgug cuccgucgug     1980

guggacggcg acaccaagca cugcgucauc uaccggaccg ccacgggcuu cggguucgcc     2040

gagcccuaca accucuacgg cagccugaag gagcuggugc uccacuacca gcacgccucc     2100

cuggugcagc acaacgacgc ccugaccguc acccucgcgc acccggugcg cgcccccggg     2160

cccggccccc cgcccgccgc ccgguga                                         2187


<210>  9196
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAD22671

<400>  9196
auggccggcc ccgagggcuu ccaguaccgc gcccucuacc ccuuccgccg cgagcgcccc       60

gaggaccucg agcuccuccc cggcgacguc cucgucgucu cccgcgccgc ccuccaggcc      120

cucggcgucg ccgagggcgg cgagcgcugc ccccaguccg ucggcuggau gcccggccuc      180

aacgagcgca cccgccagcg cggcgacuuc cccggcaccu acgucgaguu ccucggcccc      240

gucgcccucg cccgccccgg cccccgcccc cgcggccccc gcccccuccc cgcccgcccc      300

cgcgacggcg cccccgagcc cggccucacc cuccccgacc uccccgagca guucuccccc      360

cccgacgucg cccccccccu ccucgucaag cucgucgagg ccaucgagcg caccggccuc      420

gacuccgagu cccacuaccg ccccgagcuc cccgcccccc gcaccgacug gucccucucc      480

gacgucgacc agugggacac cgccgcccuc gccgacggca ucaaguccuu ccuccucgcc      540

cuccccgccc cccucgucac ccccgaggcc uccgccgagg cccgccgcgc ccuccgcgag      600

gccgccggcc ccgucggccc cgcccucgag ccccccaccc ucccccucca ccgcgcccuc      660

acccuccgcu uccuccucca gcaccucggc cgcgucgccu cccgcgcccc cgcccucggc      720

cccgccgucc gcgcccucgg cgccaccuuc ggcccccucc uccuccgcgc cccccccccc      780

cccuccuccc ccccccccgg cggcgccccc gacggcuccg agcccucccc cgacuucccc      840

gcccuccucg ucgagaagcu ccuccaggag caccucgagg agcaggaggu cgcccccccc      900

gcccuccccc ccaagccccc caaggccaag cccgccucca ccguccucgc caacggcggc      960

uccccccccu cccuccagga cgccgagugg uacuggggcg acaucucccg cgaggagguc     1020

aacgagaagc uccgcgacac ccccgacggc accuuccucg uccgcgacgc cuccuccaag     1080

auccagggcg aguacacccu cacccuccgc aagggcggca acaacaagcu caucaagguc     1140

uuccaccgcg acggccacua cggcuucucc gagccccuca ccuucugcuc cgucgucgac     1200

cucaucaacc acuaccgcca cgagucccuc gcccaguaca acgccaagcu cgacacccgc     1260

cuccucuacc ccgucuccaa guaccagcag gaccagaucg ucaaggagga cuccgucgag     1320

gccgucggcg cccagcucaa ggucuaccac cagcaguacc aggacaaguc ccgcgaguac     1380

gaccagcucu acgaggagua cacccgcacc ucccaggagc uccagaugaa gcgcaccgcc     1440

aucgaggccu ucaacgagac caucaagauc uucgaggagc agggccagac ccaggagaag     1500

ugcuccaagg aguaccucga gcgcuuccgc cgcgagggca acgagaagga gaugcagcgc     1560

auccuccuca acuccgagcg ccucaagucc cgcaucgccg agauccacga gucccgcacc     1620

aagcucgagc agcagcuccg cgcccaggcc uccgacaacc gcgagaucga caagcgcaug     1680

aacucccuca agcccgaccu caugcagcuc cgcaagaucc gcgaccagua ccucgucugg     1740

cucacccaga agggcgcccg ccagaagaag aucaacgagu ggcucggcau caagaacgag     1800

accgaggacc aguacgcccu cauggaggac gaggacgacc ucccccacca cgaggagcgc     1860

accugguacg ucggcaagau caaccgcacc caggccgagg agaugcucuc cggcaagcgc     1920

gacggcaccu uccucauccg cgaguccucc cagcgcggcu gcuacgccug cuccgucguc     1980

gucgacggcg acaccaagca cugcgucauc uaccgcaccg ccaccggcuu cggcuucgcc     2040

gagcccuaca accucuacgg cucccucaag gagcucgucc uccacuacca gcacgccucc     2100

cucguccagc acaacgacgc ccucaccguc acccucgccc accccguccg cgcccccggc     2160

cccggccccc cccccgccgc ccgcuga                                         2187


<210>  9197
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAD22671

<400>  9197
auggccggcc ccgagggguu ccaguacaga gcucuguauc cuuuuaggcg ggaacgccca       60

gaggaccucg aacuucugcc gggagaugug uuggucguua gccgagcagc cuuacaagcg      120

cugggugugg cugagggcgg ggaacguugc ccccaguccg uaggauggau gccuggccua      180

aacgagagaa ccaggcagcg gggugacuuc ccagggacau acguggaguu ucucggaccc      240

gucgcccugg cacgcccugg cccaagaccc aggggcccuc ggccacuucc ggcccgcccc      300

cgagaugggg cuccugaacc aggacugacu uugcccgacc ucccugagca guucucucca      360

cccgaugugg caccgccucu gcugguuaag cucguggaag ccaucgagag aacggguuua      420

gacucagaga gucacuauag gcccgaacug ccagcuccuc ggaccgauug gagccuuucc      480

gacgucgauc aaugggacac agccgcguug gcagauggca uuaaaucuuu ucugcuagcc      540

cuccccgcuc cacuggugac ucccgaggcc ucggcagaag cucgucgcgc ccuuagagag      600

gcggccgggc cuguaggacc agcacuggaa ccgcccaccu ugccucucca uagggcucug      660

acauuacggu uccugcucca gcaccuuggc cgaguugccu cacgcgcucc agcccugggu      720

cccgcaguga gagccuuggg ggcuaccuuu ggaccucuac ugcucagggc gccacccccg      780

ccuagcaguc cacccccugg cggcgcaccc gacggguccg agccaucucc ugauuucccc      840

gcccugcuug ucgagaagcu guugcaggaa caucucgagg aacaggaggu ggcuccaccg      900

gcccugccuc ccaaaccacc caaggcaaaa ccugccagca cuguguuagc uaauggaggu      960

uccccacccu cacugcaaga cgccgaaugg uacuggggcg acauaagucg ggaggagguc     1020

aacgaaaagc uacgcgauac accugacggg accuuucucg uuagagaugc aagcucuaag     1080

auccagggag aguauacgcu gacucuuagg aaaggcggua auaacaaguu gauuaaagug     1140

uuccaccgug acgggcauua cggcuuuucc gaaccgcuga ccuucuguuc aguaguggau     1200

cucaucaauc acuaucggca cgagagccug gcgcaguaca acgcuaaacu ugacacacga     1260

cuguuguacc cagucaguaa guaucagcaa gaucagauug ugaaggaaga cucuguugag     1320

gccgugggag cacagcucaa ggucuaccau caacaguauc aggauaaauc cagagaguac     1380

gaccagcugu augaagagua cacuaggacc agccaagaau uacagaugaa gcgcacagcc     1440

aucgaggcuu uuaaugagac cauaaaaauc uucgaagaac agggccagac gcaagaaaag     1500

ugcucgaaag aguaucugga acgguucaga agggagggga acgagaagga aaugcagcgc     1560

auucuacuca auucugagcg acugaaaucc cggaucgccg aaauucacga gucacguacu     1620

aaacuugaac agcaguugag agcacaagcu agugauaaca gggagaucga caagcgcaug     1680

aauagccuga agcccgaccu caugcagcug cggaagauaa gagaucagua cuuagugugg     1740

cugacacaga aaggagccag gcaaaagaaa auuaacgagu ggcuugguau caagaaugaa     1800

accgaggacc aguacgcguu gauggaagau gaggacgauc ucccucauca cgaggagcga     1860

acuugguaug uaggcaagau uaaccgcaca caggccgagg aaaugcuguc cgggaaacgg     1920

gacggaaccu uucuaaucag agagucuagc caaaggggcu guuacgcuug cucaguugug     1980

gucgauggug acacgaagca cugugugauc uaucguaccg caacaggguu cggcuuugcc     2040

gaaccauaca aucuguaugg aagucucaaa gagcuggucc uucauuacca gcacgcuucc     2100

uuggugcagc auaacgaugc ccugacuguu accuuagcac accccgugcg cgcgccuggc     2160

ccggggcccc cuccagccgc ucgguga                                         2187


<210>  9198
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAD22671

<400>  9198
auggccggcc ccgagggcuu ccaguacaga gcccuguacc ccuucagaag agagagaccc       60

gaggaccugg agcugcugcc cggcgacgug cuggugguga gcagagccgc ccugcaggcc      120

cugggcgugg ccgagggcgg cgagagaugc ccccagagcg ugggcuggau gcccggccug      180

aacgagagaa ccagacagag aggcgacuuc cccggcaccu acguggaguu ccugggcccc      240

guggcccugg ccagacccgg ccccagaccc agaggcccca gaccccugcc cgccagaccc      300

agagacggcg cccccgagcc cggccugacc cugcccgacc ugcccgagca guucagcccc      360

cccgacgugg cccccccccu gcuggugaag cugguggagg ccaucgagag aaccggccug      420

gacagcgaga gccacuacag acccgagcug cccgccccca gaaccgacug gagccugagc      480

gacguggacc agugggacac cgccgcccug gccgacggca ucaagagcuu ccugcuggcc      540

cugcccgccc cccuggugac ccccgaggcc agcgccgagg ccagaagagc ccugagagag      600

gccgccggcc ccgugggccc cgcccuggag ccccccaccc ugccccugca cagagcccug      660

acccugagau uccugcugca gcaccugggc agaguggcca gcagagcccc cgcccugggc      720

cccgccguga gagcccuggg cgccaccuuc ggcccccugc ugcugagagc cccccccccc      780

cccagcagcc ccccccccgg cggcgccccc gacggcagcg agcccagccc cgacuucccc      840

gcccugcugg uggagaagcu gcugcaggag caccuggagg agcaggaggu ggcccccccc      900

gcccugcccc ccaagccccc caaggccaag cccgccagca ccgugcuggc caacggcggc      960

agccccccca gccugcagga cgccgagugg uacuggggcg acaucagcag agaggaggug     1020

aacgagaagc ugagagacac ccccgacggc accuuccugg ugagagacgc cagcagcaag     1080

auccagggcg aguacacccu gacccugaga aagggcggca acaacaagcu gaucaaggug     1140

uuccacagag acggccacua cggcuucagc gagccccuga ccuucugcag cgugguggac     1200

cugaucaacc acuacagaca cgagagccug gcccaguaca acgccaagcu ggacaccaga     1260

cugcuguacc ccgugagcaa guaccagcag gaccagaucg ugaaggagga cagcguggag     1320

gccgugggcg cccagcugaa gguguaccac cagcaguacc aggacaagag cagagaguac     1380

gaccagcugu acgaggagua caccagaacc agccaggagc ugcagaugaa gagaaccgcc     1440

aucgaggccu ucaacgagac caucaagauc uucgaggagc agggccagac ccaggagaag     1500

ugcagcaagg aguaccugga gagauucaga agagagggca acgagaagga gaugcagaga     1560

auccugcuga acagcgagag acugaagagc agaaucgccg agauccacga gagcagaacc     1620

aagcuggagc agcagcugag agcccaggcc agcgacaaca gagagaucga caagagaaug     1680

aacagccuga agcccgaccu gaugcagcug agaaagauca gagaccagua ccuggugugg     1740

cugacccaga agggcgccag acagaagaag aucaacgagu ggcugggcau caagaacgag     1800

accgaggacc aguacgcccu gauggaggac gaggacgacc ugccccacca cgaggagaga     1860

accugguacg ugggcaagau caacagaacc caggccgagg agaugcugag cggcaagaga     1920

gacggcaccu uccugaucag agagagcagc cagagaggcu gcuacgccug cagcguggug     1980

guggacggcg acaccaagca cugcgugauc uacagaaccg ccaccggcuu cggcuucgcc     2040

gagcccuaca accuguacgg cagccugaag gagcuggugc ugcacuacca gcacgccagc     2100

cuggugcagc acaacgacgc ccugaccgug acccuggccc accccgugag agcccccggc     2160

cccggccccc cccccgccgc cagauga                                         2187


<210>  9199
<211>  2187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAD22671

<400>  9199
auggccggcc ccgagggguu ccaguacaga gcucuguauc cuuuucggcg cgaaagaccg       60

gaggaccucg aacugcuucc cggagaugug cuggucguua gccgggccgc gcuccaagcu      120

cugggcgugg ccgaaggggg agaacgcugc ccucaguccg ugggcuggau gcccgggcuu      180

aacgagagaa cccggcagcg cggagacuuc ccuggcacau acgucgaguu ucugggcccc      240

guggcccucg cuagaccugg gccgcggccc cgcggaccua gaccccugcc ugcccggccc      300

cgcgauggcg cuccggaacc ugggcugacg cuccccgacc ugccugagca guucucuccu      360

cccgauguug ccccuccgcu ucuggugaag cucgucgaag cgaucgagag aaccggacug      420

gacagcgagu cccacuaucg gcccgaacuu ccugcucccc gcacagauug gucucugagc      480

gacguggauc aaugggacac cgccgcccuc gcugauggca uuaaauccuu ucugcuggcc      540

cucccugcgc cccugguuac accggaggcc ucugcugaag ccagacgggc ucuuagagag      600

gccgccgggc cugugggacc cgcucuggaa ccucccaccc ucccucugca ucgcgcgcuu      660

acacugcggu uccuccugca gcaccugggc agagucgcca gccgcgcucc cgcccucggc      720

ccggccgugc gggcucuggg ggccaccuuu ggaccucuuc ugcucagagc gcccccgccu      780

cccuccucuc ccccucccgg cggggcuccc gacggaagcg agcccucccc ugauuucccc      840

gcccugcuug uggagaagcu gcuccaggaa caucuggagg aacaggaggu cgccccgccu      900

gcucugcccc cuaaaccccc gaaggccaaa ccugcuagca cgguucucgc caauggcggg      960

ucucccccuu cccugcaaga cgcggaaugg uacuggggag acaucagccg cgaggaggug     1020

aacgaaaagc ugcgggauac ccccgacggc acauuucuug ugagagaugc cucuuccaag     1080

auucagggcg aguauacccu cacacugcgc aaagggggaa auaacaagcu gaucaaaguc     1140

uuccaccggg acggccauua cggguuuagc gaaccccuua ccuucuguuc cgugguugau     1200

cucauuaauc acuauagaca cgagucucug gcucaguaca acgccaagcu ggacacgcgc     1260

cuccuguacc cugugagcaa auaucagcaa gaucagaucg ucaaggaaga cuccguggag     1320

gcuguuggag cccagcuuaa gguguaccau caacaguauc aggauaaaag ccgggaguac     1380

gaccagcugu augaagagua cacaagaacc ucucaagaac uccagaugaa gcggacagcg     1440

aucgaggccu uuaaugagac cauuaaaauc uucgaggagc agggccagac ccaagaaaag     1500

ugcuccaaag aguaucugga acgcuucaga cgggagggga acgagaagga aaugcagcgc     1560

auucugcuua auagcgagag acucaaaucu cggaucgcug aaauucacga gagcagaaca     1620

aagcuggaac agcagcugcg cgcccaggcu uccgauaaca gagagaucga caagcggaug     1680

aacucucuca aaccggaccu gaugcaacuu cgcaagauua gagaucagua ccuggucugg     1740

cucacgcaga aaggcgcccg gcaaaagaaa aucaaugagu ggcugggaau caagaaugaa     1800

accgaggacc aguacgcccu gauggaagau gaggacgauc uuccccauca cgaggaacgc     1860

acaugguaug ugggcaagau uaacagaacc caggcugagg aaaugcucag cgggaaacgg     1920

gacggaacau uucugauccg cgaguccagc caaagaggcu guuacgcgug cucugucgug     1980

guugaugggg acaccaagca cugugugauu uaucggacgg ccacaggauu cggcuuugcu     2040

gaaccuuaca aucuguaugg gucccucaaa gagcuggucc uucauuacca gcacgccagc     2100

cuggugcagc auaacgaugc ccucaccguu acccuggcuc accccgugcg cgccccuggc     2160

cccggaccuc cgcccgcggc uagauga                                         2187


<210>  9200
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__P27986

<400>  9200

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  9201
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAH94795

<400>  9201
augagugcug agggguacca guacagagcg cuguaugauu auaaaaagga aagagaagaa       60

gauauugacu ugcacuuggg ugacauauug acugugaaua aaggguccuu aguagcucuu      120

ggauucagug auggacagga agccaggccu gaagaaauug gcugguuaaa uggcuauaau      180

gaaaccacag gggaaagggg ggacuuuccg ggaacuuacg uagaauauau uggaaggaaa      240

aaaaucucgc cucccacacc aaagccccgg ccaccucggc cucuuccugu ugcaccaggu      300

ucuucgaaaa cugaagcaga uguugaacaa caagcuuuga cucucccgga ucuugcagag      360

caguuugccc cuccugacau ugccccgccu cuucuuauca agcucgugga agccauugaa      420

aagaaagguc uggaauguuc aacucuauac agaacacaga gcuccagcaa ccuggcagaa      480

uuacgacagc uucuugauug ugauacaccc uccguggacu uggaaaugau cgaugugcac      540

guuuuggcug acgcuuucaa acgcuaucuc cuggacuuac caaauccugu cauuccagca      600

gccguuuaca gugaaaugau uucuuuagcu ccagaaguac aaagcuccga agaauauauu      660

cagcuauuga agaagcuuau uaggucgccu agcauaccuc aucaguauug gcuuacgcuu      720

caguauuugu uaaaacauuu cuucaagcuc ucucaaaccu ccagcaaaaa ucuguugaau      780

gcaagaguac ucucugaaau uuucagcccu augcuuuuca gauucucagc agccagcucu      840

gauaauacug aaaaccucau aaaaguuaua gaaauuuuaa ucucaacuga auggaaugaa      900

cgacagccug caccagcacu gccuccuaaa ccaccaaaac cuacuacugu agccaacaac      960

gguaugaaua acaauauguc cuuacaagau gcugaauggu acuggggaga uaucucgagg     1020

gaagaaguga augaaaaacu ucgagauaca gcagacggga ccuuuuuggu acgagaugcg     1080

ucuacuaaaa ugcaugguga uuauacucuu acacuaagga aagggggaaa uaacaaauua     1140

aucaaaauau uucaucgaga ugggaaauau ggcuucucug acccauuaac cuucaguucu     1200

gugguugaau uaauaaacca cuaccggaau gaaucucuag cucaguauaa ucccaaauug     1260

gaugugaaau uacuuuaucc aguauccaaa uaccaacagg aucaaguugu caaagaagau     1320

aauauugaag cuguagggaa aaaauuacau gaauauaaca cucaguuuca agaaaaaagu     1380

cgagaauaug auagauuaua ugaagaauau acccgcacau cccaggaaau ccaaaugaaa     1440

aggacagcua uugaagcauu uaaugaaacc auaaaaauau uugaagaaca gugccagacc     1500

caagagcggu acagcaaaga auacauagaa aaguuuaaac gugaaggcaa ugagaaagaa     1560

auacaaagga uuaugcauaa uuaugauaag uugaagucuc gaaucaguga aauuauugac     1620

aguagaagaa gauuggaaga agacuugaag aagcaggcag cugaguaucg agaaauugac     1680

aaacguauga acagcauuaa accagaccuu auccagcuga gaaagacgag agaccaauac     1740

uugauguggu ugacucaaaa agguguucgg caaaagaagu ugaacgagug guugggcaau     1800

gaaaacacug aagaccaaua uucacuggug gaagaugaug aagauuugcc ccaucaugau     1860

gagaagacau ggaauguugg aagcagcaac cgaaacaaag cugaaaaccu guugcgaggg     1920

aagcgagaug gcacuuuucu uguccgggag agcaguaaac agggcugcua ugccugcucu     1980

guaguggugg acggcgaagu aaagcauugu gucauaaaca aaacagcaac uggcuauggc     2040

uuugccgagc ccuauaacuu guacagcucu cugaaagaac uggugcuaca uuaccaacac     2100

accucccuug ugcagcacaa cgacucccuc aaugucacac uagccuaccc aguauaugca     2160

cagcagaggc gauga                                                      2175


<210>  9202
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAH94795

<400>  9202
augagcgccg agggcuacca guaccgcgcc cuguacgacu acaagaagga gcgggaggag       60

gacaucgacc uccaccuggg ggacauccug accgugaaca agggcucccu cgucgcgcug      120

ggguucagcg acggccagga ggcccgcccc gaggagaucg gguggcugaa cggcuacaac      180

gagaccacgg gcgagcgcgg ggacuucccg ggcaccuacg uggaguacau cgggcggaag      240

aagaucuccc cgcccacccc caagccccgg ccgccccgcc cccuccccgu ggcccccggc      300

agcuccaaga ccgaggccga cgucgagcag caggcccuga cgcugcccga ccucgcggag      360

caguucgcgc ccccggacau cgccccgccc cugcugauca agcucgugga ggccaucgag      420

aagaaggggc uggagugcag cacccuguac cggacccagu ccagcuccaa ccucgccgag      480

cugcgccagc ugcucgacug cgacaccccc agcguggacc uggagaugau cgacguccac      540

gugcuggccg acgccuucaa gcgguaccuc cuggaccugc ccaaccccgu gauccccgcc      600

gccgucuacu ccgagaugau cagccucgcg cccgaggugc aguccagcga ggaguacauc      660

cagcugcuga agaagcucau ccgcuccccg agcauccccc accaguacug gcugacgcug      720

caguaccucc ugaagcacuu cuucaagcug ucccagacca gcuccaagaa ccuccugaac      780

gcccgggugc ugagcgagau cuucagcccc augcuguucc gcuucuccgc cgccagcucc      840

gacaacaccg agaaccugau caaggucauc gagauccuga ucagcaccga guggaacgag      900

cggcagcccg ccccggcgcu cccgcccaag ccgcccaagc ccacgaccgu ggccaacaac      960

ggcaugaaca acaacauguc ccugcaggac gccgaguggu acuggggcga caucagccgc     1020

gaggagguga acgagaagcu gcgggacacc gccgacggga ccuuccucgu ccgcgacgcc     1080

uccacgaaga ugcacggcga cuacacccug acccugcgga agggcgggaa caacaagcuc     1140

aucaagaucu uccaccgcga cggcaaguac ggguucagcg acccccugac cuucuccagc     1200

gugguggagc ugaucaacca cuaccggaac gagucccucg cgcaguacaa ccccaagcug     1260

gacgucaagc ugcuguaccc cgugagcaag uaccagcagg accagguggu caaggaggac     1320

aacaucgagg ccgugggcaa gaagcuccac gaguacaaca cgcaguucca ggagaagucc     1380

cgcgaguacg accggcugua cgaggaguac acccgcacca gccaggagau ccagaugaag     1440

cgcaccgcca ucgaggccuu caacgagacg aucaagaucu ucgaggagca gugccagacc     1500

caggagcggu acuccaagga guacaucgag aaguucaagc gcgaggggaa cgagaaggag     1560

auccagcgga ucaugcacaa cuacgacaag cucaagagcc gcaucuccga gaucaucgac     1620

agccggcgcc ggcucgagga ggaccugaag aagcaggccg cggaguaccg cgagaucgac     1680

aagcggauga acuccaucaa gcccgaccug auccagcucc gcaagacccg ggaccaguac     1740

cugauguggc ugacccagaa gggcgugcgc cagaagaagc ucaacgagug gcuggggaac     1800

gagaacacgg aggaccagua cagccugguc gaggacgacg aggaccuccc ccaccacgac     1860

gagaagaccu ggaacguggg cagcuccaac cggaacaagg ccgagaaccu gcugcgcggc     1920

aagcgggacg ggaccuuccu cguccgcgag agcuccaagc agggcugcua cgccugcagc     1980

gugguggucg acggggaggu gaagcacugc gugaucaaca agaccgccac gggcuacggg     2040

uucgcggagc cguacaaccu guacuccagc cugaaggagc ucguccugca cuaccagcac     2100

accucccugg ugcagcacaa cgacagccuc aacgugaccc uggccuaccc cgucuacgcc     2160

cagcagcggc gcuga                                                      2175


<210>  9203
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAH94795

<400>  9203
auguccgccg agggcuacca guaccgcgcc cucuacgacu acaagaagga gcgcgaggag       60

gacaucgacc uccaccucgg cgacauccuc accgucaaca agggcucccu cgucgcccuc      120

ggcuucuccg acggccagga ggcccgcccc gaggagaucg gcuggcucaa cggcuacaac      180

gagaccaccg gcgagcgcgg cgacuucccc ggcaccuacg ucgaguacau cggccgcaag      240

aagaucuccc cccccacccc caagccccgc cccccccgcc cccuccccgu cgcccccggc      300

uccuccaaga ccgaggccga cgucgagcag caggcccuca cccuccccga ccucgccgag      360

caguucgccc cccccgacau cgcccccccc cuccucauca agcucgucga ggccaucgag      420

aagaagggcc ucgagugcuc cacccucuac cgcacccagu ccuccuccaa ccucgccgag      480

cuccgccagc uccucgacug cgacaccccc uccgucgacc ucgagaugau cgacguccac      540

guccucgccg acgccuucaa gcgcuaccuc cucgaccucc ccaaccccgu cauccccgcc      600

gccgucuacu ccgagaugau cucccucgcc cccgaggucc aguccuccga ggaguacauc      660

cagcuccuca agaagcucau ccgcuccccc uccauccccc accaguacug gcucacccuc      720

caguaccucc ucaagcacuu cuucaagcuc ucccagaccu ccuccaagaa ccuccucaac      780

gcccgcgucc ucuccgagau cuucuccccc augcucuucc gcuucuccgc cgccuccucc      840

gacaacaccg agaaccucau caaggucauc gagauccuca ucuccaccga guggaacgag      900

cgccagcccg cccccgcccu cccccccaag ccccccaagc ccaccaccgu cgccaacaac      960

ggcaugaaca acaacauguc ccuccaggac gccgaguggu acuggggcga caucucccgc     1020

gaggagguca acgagaagcu ccgcgacacc gccgacggca ccuuccucgu ccgcgacgcc     1080

uccaccaaga ugcacggcga cuacacccuc acccuccgca agggcggcaa caacaagcuc     1140

aucaagaucu uccaccgcga cggcaaguac ggcuucuccg acccccucac cuucuccucc     1200

gucgucgagc ucaucaacca cuaccgcaac gagucccucg cccaguacaa ccccaagcuc     1260

gacgucaagc uccucuaccc cgucuccaag uaccagcagg accaggucgu caaggaggac     1320

aacaucgagg ccgucggcaa gaagcuccac gaguacaaca cccaguucca ggagaagucc     1380

cgcgaguacg accgccucua cgaggaguac acccgcaccu cccaggagau ccagaugaag     1440

cgcaccgcca ucgaggccuu caacgagacc aucaagaucu ucgaggagca gugccagacc     1500

caggagcgcu acuccaagga guacaucgag aaguucaagc gcgagggcaa cgagaaggag     1560

auccagcgca ucaugcacaa cuacgacaag cucaaguccc gcaucuccga gaucaucgac     1620

ucccgccgcc gccucgagga ggaccucaag aagcaggccg ccgaguaccg cgagaucgac     1680

aagcgcauga acuccaucaa gcccgaccuc auccagcucc gcaagacccg cgaccaguac     1740

cucauguggc ucacccagaa gggcguccgc cagaagaagc ucaacgagug gcucggcaac     1800

gagaacaccg aggaccagua cucccucguc gaggacgacg aggaccuccc ccaccacgac     1860

gagaagaccu ggaacgucgg cuccuccaac cgcaacaagg ccgagaaccu ccuccgcggc     1920

aagcgcgacg gcaccuuccu cguccgcgag uccuccaagc agggcugcua cgccugcucc     1980

gucgucgucg acggcgaggu caagcacugc gucaucaaca agaccgccac cggcuacggc     2040

uucgccgagc ccuacaaccu cuacuccucc cucaaggagc ucguccucca cuaccagcac     2100

accucccucg uccagcacaa cgacucccuc aacgucaccc ucgccuaccc cgucuacgcc     2160

cagcagcgcc gcuga                                                      2175


<210>  9204
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAH94795

<400>  9204
augagcgccg agggcuacca guauagagcu cuguacgacu auaagaaaga aagggaggaa       60

gauaucgacc uccaccuugg ggauauucug accgugaaca agggauccuu ggucgcauua      120

gguuucucug acggccaaga ggcccggccc gaagagauag gguggcugaa uggauacaac      180

gagacaacug gcgaacgcgg ugauuuuccu gggacguaug uugaguacau cggacgaaag      240

aagauuucac caccgacccc caaaccucgu ccacccagac cucuaccagu ggcgcccggc      300

aguagcaaga cagaagcuga cguagagcag caggcccuca cucugccuga ucuugcagag      360

caguucgccc caccggacau cgcucccccu cuguugauua agcucgugga agcaaucgag      420

aaaaagggcc uggaaugcuc cacccuguau aggacacaau cuucgucaaa ucucgccgag      480

uuacggcagc ugcuugauug ugacacccca agcgucgauu uggaaaugau agacgugcau      540

guucuggcug augccuuuaa acgcuaccua cucgaccugc ccaacccugu gaucccagcg      600

gcagucuaca gugagaugau uucccuugcc cccgaggugc agucuagcga agaguauauc      660

cagcuguuga agaaacucau uagauccccg ucaaucccuc accaauacug gcugacuuua      720

caguaucugc ucaagcauuu cuuuaaacuu agucagacaa gcucuaaaaa ucuguugaac      780

gcuaggguac uauccgaaau auucucaccc augcuguuuc gguucagcgc cgcaaguucu      840

gacaauaccg agaaccucau uaagguuauc gaaauucuga ucuccacgga guggaaugag      900

cgccagccag cuccugcccu ucccccaaaa cccccuaagc caacuaccgu ggcgaacaau      960

gggaugaaca auaacaugag ccugcaagau gccgaauggu acuggggaga caucucgcga     1020

gaggaaguca augagaaauu gagagauaca gcagacggua cuuuucucgu gagggaugcu     1080

ucuaccaaga ugcacggcga cuauacacug accuuacgga aagggggaaa caacaagcug     1140

auuaagauau uccaucguga uggcaaauac gguuuuuccg acccgcuaac guucucaagu     1200

guggucgaac ucaucaauca cuaucgcaac gagagccugg cccaguacaa ucccaaacuu     1260

gauguuaagu ugcuguaccc uguguccaag uaucagcaag accagguagu gaaagaggau     1320

aacauugaag cugucgggaa gaagcuccac gaguacaaua cucaguuuca ggaaaaaucu     1380

agagaguaug acaggcugua cgaggaauau acacggacca gccaagagau ccagaugaag     1440

cgaacugcca uagaagcauu caacgagaca auuaaaaucu ucgaggaaca gugccagacc     1500

caagagcgcu acucaaagga auauaucgag aaauuuaaga gagaaggaaa ugagaaggaa     1560

auucagagga ucaugcauaa cuacgacaaa cuuaagaguc ggauuuccga gauaaucgau     1620

agccgcagaa ggcuggagga agacuugaaa aagcaggccg cugaguaccg ugaaauugau     1680

aaacggauga acucuaucaa gccagaccuc auccagcugc gaaagacgag agaucaauau     1740

uuaauguggc ugacccagaa aggcgugagg cagaagaaac uaaaugagug gcucggcaau     1800

gaaaacacag aggaccagua cucacugguu gaggaugacg aagaucuucc ccaccaugac     1860

gagaagacuu ggaauguggg gaguagcaac cgcaauaaag cggaaaacuu gcugcgggga     1920

aagagagaug guaccuuccu cgucagggag uccucuaaac aaggcuguua ugcaugcucg     1980

gugguaguug acggggaggu gaagcacugu gucauuaaca agacagccac uggauacggc     2040

uuugcugaac cuuauaaucu guacagcucc uuaaaagagc uggugcuuca cuaucagcau     2100

accucauugg uccagcacaa cgauagucuc aaugugacac uggccuaccc aguuuacgca     2160

caacagcgcc gauga                                                      2175


<210>  9205
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAH94795

<400>  9205
augagcgccg agggcuacca guacagagcc cuguacgacu acaagaagga gagagaggag       60

gacaucgacc ugcaccuggg cgacauccug accgugaaca agggcagccu gguggcccug      120

ggcuucagcg acggccagga ggccagaccc gaggagaucg gcuggcugaa cggcuacaac      180

gagaccaccg gcgagagagg cgacuucccc ggcaccuacg uggaguacau cggcagaaag      240

aagaucagcc cccccacccc caagcccaga ccccccagac cccugcccgu ggcccccggc      300

agcagcaaga ccgaggccga cguggagcag caggcccuga cccugcccga ccuggccgag      360

caguucgccc cccccgacau cgcccccccc cugcugauca agcuggugga ggccaucgag      420

aagaagggcc uggagugcag cacccuguac agaacccaga gcagcagcaa ccuggccgag      480

cugagacagc ugcuggacug cgacaccccc agcguggacc uggagaugau cgacgugcac      540

gugcuggccg acgccuucaa gagauaccug cuggaccugc ccaaccccgu gauccccgcc      600

gccguguaca gcgagaugau cagccuggcc cccgaggugc agagcagcga ggaguacauc      660

cagcugcuga agaagcugau cagaagcccc agcauccccc accaguacug gcugacccug      720

caguaccugc ugaagcacuu cuucaagcug agccagacca gcagcaagaa ccugcugaac      780

gccagagugc ugagcgagau cuucagcccc augcuguuca gauucagcgc cgccagcagc      840

gacaacaccg agaaccugau caaggugauc gagauccuga ucagcaccga guggaacgag      900

agacagcccg cccccgcccu gccccccaag ccccccaagc ccaccaccgu ggccaacaac      960

ggcaugaaca acaacaugag ccugcaggac gccgaguggu acuggggcga caucagcaga     1020

gaggagguga acgagaagcu gagagacacc gccgacggca ccuuccuggu gagagacgcc     1080

agcaccaaga ugcacggcga cuacacccug acccugagaa agggcggcaa caacaagcug     1140

aucaagaucu uccacagaga cggcaaguac ggcuucagcg acccccugac cuucagcagc     1200

gugguggagc ugaucaacca cuacagaaac gagagccugg cccaguacaa ccccaagcug     1260

gacgugaagc ugcuguaccc cgugagcaag uaccagcagg accagguggu gaaggaggac     1320

aacaucgagg ccgugggcaa gaagcugcac gaguacaaca cccaguucca ggagaagagc     1380

agagaguacg acagacugua cgaggaguac accagaacca gccaggagau ccagaugaag     1440

agaaccgcca ucgaggccuu caacgagacc aucaagaucu ucgaggagca gugccagacc     1500

caggagagau acagcaagga guacaucgag aaguucaaga gagagggcaa cgagaaggag     1560

auccagagaa ucaugcacaa cuacgacaag cugaagagca gaaucagcga gaucaucgac     1620

agcagaagaa gacuggagga ggaccugaag aagcaggccg ccgaguacag agagaucgac     1680

aagagaauga acagcaucaa gcccgaccug auccagcuga gaaagaccag agaccaguac     1740

cugauguggc ugacccagaa gggcgugaga cagaagaagc ugaacgagug gcugggcaac     1800

gagaacaccg aggaccagua cagccuggug gaggacgacg aggaccugcc ccaccacgac     1860

gagaagaccu ggaacguggg cagcagcaac agaaacaagg ccgagaaccu gcugagaggc     1920

aagagagacg gcaccuuccu ggugagagag agcagcaagc agggcugcua cgccugcagc     1980

gugguggugg acggcgaggu gaagcacugc gugaucaaca agaccgccac cggcuacggc     2040

uucgccgagc ccuacaaccu guacagcagc cugaaggagc uggugcugca cuaccagcac     2100

accagccugg ugcagcacaa cgacagccug aacgugaccc uggccuaccc cguguacgcc     2160

cagcagagaa gauga                                                      2175


<210>  9206
<211>  2175
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAH94795

<400>  9206
augagcgccg agggcuacca guauagagcu cuguacgacu auaagaaaga acgggaggaa       60

gauaucgacc uccaccuggg ggauauucuu accgugaaca agggaucccu ggucgcccuc      120

ggcuucucug acgggcaaga ggcgcgcccc gaagagaucg gauggcugaa uggcuacaac      180

gagacaacgg gggaaagagg agauuuuccu ggcaccuaug uugaguacau uggccggaaa      240

aagaucagcc cgcccacacc uaaaccccgc ccucccagac cucuuccggu ggcucccggg      300

uccucuaaga ccgaagccga cguggagcag caggcccuga cacucccuga ucuggcugag      360

caguucgcuc ccccugacau ugcucccccg cugcucauca agcuggucga agccaucgag      420

aaaaagggac uugaaugcag cacccuguau cggacacaau ccucuagcaa ucucgcggag      480

cugcgccagc uucuggauug ugacaccccu uccguggauc ucgaaaugau ugacguucau      540

gugcuggccg augcuuuuaa aagauaccug cucgaccugc ccaacccugu cauccccgcc      600

gcuguguaca gcgagaugau uucucuugcc cccgagguuc aguccagcga agaguauauc      660

cagcugcuca agaaacugau ucggucuccu uccaucccgc accaauacug gcuuacgcug      720

caguaucucc ugaagcauuu cuuuaagcug agccagaccu cuuccaaaaa ucuccugaac      780

gcgcgcgugc uuagcgaaau uuucuccccc augcuguuua gauucucugc cgcuagcucc      840

gacaauacag agaaccucau caaggucauc gaaauucuga ucagcaccga guggaaugag      900

cggcagccug cccccgcccu uccucccaaa ccgccuaagc ccacaaccgu ggccaacaau      960

ggcaugaaca auaacauguc ucugcaagau gccgaauggu acuggggaga cauuucccgc     1020

gaggaaguga augagaaacu cagagauacg gcugacggga cauuucuggu ccgggaugcg     1080

agcaccaaga ugcacggcga cuauacacug acccuccgca aagggggaaa caacaagcug     1140

aucaagauuu uccauagaga uggcaaauac ggcuuuucug acccucuuac cuucagcucc     1200

guuguggaac ugaucaauca cuaucggaac gagucucucg cccaguacaa ucccaagcug     1260

gaugugaaac ugcuuuaccc ugucagcaag uaucagcaag accagguggu uaaagaggau     1320

aacaucgaag cuguggggaa gaagcuccac gaguacaaua cacaguuuca ggaaaaaucc     1380

agagaguaug accgccugua cgaggaauau acgcggacca gccaagagau ucagaugaag     1440

agaacagcca ucgaagccuu caacgagacc auuaaaaucu ucgaggaaca gugccagaca     1500

caagagcgcu acucuaagga auauauugag aaauuuaagc gggaaggaaa ugagaaggaa     1560

auccagagaa ucaugcauaa cuacgacaaa cugaaguccc gcauuagcga gaucauugau     1620

ucucggagac gccucgagga agaccugaaa aagcaggcug ccgaguaccg ggaaaucgau     1680

aaaagaauga acuccauuaa gcccgaccuu auccagcugc gcaagacccg ggaucaauau     1740

cucauguggc ugacgcagaa aggcgucaga cagaagaaac ugaaugagug gcuugggaau     1800

gaaaacacag aggaccagua cagccucgug gaggaugacg aagaucugcc gcaccaugac     1860

gagaagaccu ggaauguugg auccucuaac cggaauaaag cggaaaaccu gcuccgcggc     1920

aagagagaug ggaccuuccu ggugcgggag agcuccaaac aaggauguua ugcuugcucu     1980

gucguggucg acggcgaggu gaagcacugu guuauuaaca agacagccac cggcuacggg     2040

uuugccgaac cuuauaaucu uuacagcucc cugaaagagc ucgugcugca cuaucagcau     2100

acaagccugg uccagcacaa cgauucucuu aaugugacgc ucgcuuaccc cguuuacgcc     2160

caacagagac gcuga                                                      2175


<210>  9207
<211>  1068
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__P42336

<400>  9207

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn Leu Phe Ser Met Met Leu Gly Ser 
        995                 1000                1005            


Gly Met Pro Glu Leu Gln Ser Phe Asp Asp Ile Ala Tyr Ile Arg Lys 
    1010                1015                1020                


Thr Leu Ala Leu Asp Lys Thr Glu Gln Glu Ala Leu Glu Tyr Phe Met 
1025                1030                1035                1040


Lys Gln Met Asn Asp Ala His His Gly Gly Trp Thr Thr Lys Met Asp 
                1045                1050                1055    


Trp Ile Phe His Thr Ile Lys Gln His Ala Leu Asn 
            1060                1065            


<210>  9208
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAB39753

<400>  9208
augccuccaa gaccaucauc aggugaacug uggggcaucc acuugaugcc cccaagaauc       60

cuaguagaau guuuacuacc aaauggaaug auagugacuu uagaaugccu ccgugaggcu      120

acauuaauaa ccauaaagca ugaacuauuu aaagaagcaa gaaaauaccc ccuccaucaa      180

cuucuucaag augaaucuuc uuacauuuuc guaaguguua cccaagaagc agaaagggaa      240

gaauuuuuug augaaacaag acgacuuugu gaccuucggc uuuuucaacc cuuuuuaaaa      300

guaauugaac caguaggcaa ccgugaagaa aagauccuca aucgagaaau ugguuuugcu      360

aucggcaugc caguguguga auuugauaug guuaaagauc cagaaguaca ggacuuccga      420

agaaauauuc ugaacguuug uaaagaagcu guggaucuua gggaccucaa uucaccucau      480

aguagagcaa uguaugucua uccuccaaau guagaaucuu caccagaauu gccaaagcac      540

auauauaaua aauuagauaa agggcaaaua auagugguga ucuggguaau aguuucucca      600

aauaaugaca agcagaagua uacucugaaa aucaaccaug acuguguacc agaacaagua      660

auugcugaag caaucaggaa aaaaacucga aguauguugc uauccucuga acaacuaaaa      720

cucuguguuu uagaauauca gggcaaguau auuuuaaaag uguguggaug ugaugaauac      780

uuccuagaaa aauauccucu gagucaguau aaguauauaa gaagcuguau aaugcuuggg      840

aggaugccca auuugauguu gauggcuaaa gaaagccucu auucucaacu gccaauggac      900

uguuuuacaa ugccaucuua uuccagacgc auuuccacag cuacaccaua uaugaaugga      960

gaaacaucua caaaaucccu uuggguuaua aauagugcac ucagaauaaa aauucuuugu     1020

gcaaccuacg ugaauguaaa uauucgagac auugauaaga ucuauguucg aacagguauc     1080

uaccauggag gagaacccuu augugacaau gugaacacuc aaagaguacc uuguuccaau     1140

cccaggugga augaauggcu gaauuaugau auauacauuc cugaucuucc ucgugcugcu     1200

cgacuuugcc uuuccauuug cucuguuaaa ggccgaaagg gugcuaaaga ggaacacugu     1260

ccauuggcau ggggaaauau aaacuuguuu gauuacacag acacucuagu aucuggaaaa     1320

auggcuuuga aucuuuggcc aguaccucau ggacuagaag auuugcugaa cccuauuggu     1380

guuacuggau caaauccaaa uaaagaaacu ccaugcuuag aguuggaguu ugacugguuc     1440

agcagugugg uaaaguuccc agauauguca gugauugaag agcaugccaa uuggucugua     1500

ucccgagaag caggauuuag cuauucccac gcaggacuga guaacagacu agcuagagac     1560

aaugaauuaa gggaaaauga caaagaacag cucaaagcaa uuucuacacg agauccucuc     1620

ucugaaauca cugagcagga gaaagauuuu cuauggaguc acagacacua uuguguaacu     1680

auccccgaaa uucuacccaa auugcuucug ucuguuaaau ggaauucuag agaugaagua     1740

gcccagaugu auugcuuggu aaaagauugg ccuccaauca aaccugaaca ggcuauggaa     1800

cuucuggacu guaauuaccc agauccuaug guucgagguu uugcuguucg gugcuuggaa     1860

aaauauuuaa cagaugacaa acuuucucag uauuuaauuc agcuaguaca gguccuaaaa     1920

uaugaacaau auuuggauaa cuugcuugug agauuuuuac ugaagaaagc auugacuaau     1980

caaaggauug ggcacuuuuu cuuuuggcau uuaaaaucug agaugcacaa uaaaacaguu     2040

agccagaggu uuggccugcu uuuggagucc uauugucgug caugugggau guauuugaag     2100

caccugaaua ggcaagucga ggcaauggaa aagcucauua acuuaacuga cauucucaaa     2160

caggagaaga aggaugaaac acaaaaggua cagaugaagu uuuuaguuga gcaaaugagg     2220

cgaccagauu ucauggaugc ucuacagggc uuucugucuc cucuaaaccc ugcucaucaa     2280

cuaggaaacc ucaggcuuga agagugucga auuauguccu cugcaaaaag gccacugugg     2340

uugaauuggg agaacccaga caucauguca gaguuacugu uucagaacaa ugagaucauc     2400

uuuaaaaaug gggaugauuu acggcaagau augcuaacac uucaaauuau ucguauuaug     2460

gaaaauaucu ggcaaaauca aggucuugau cuucgaaugu uaccuuaugg uugucuguca     2520

aucggugacu gugugggacu uauugaggug gugcgaaauu cucacacuau uaugcaaauu     2580

cagugcaaag gcggcuugaa aggugcacug caguucaaca gccacacacu acaucagugg     2640

cucaaagaca agaacaaagg agaaauauau gaugcagcca uugaccuguu uacacguuca     2700

ugugcuggau acuguguagc uaccuucauu uugggaauug gagaucguca caauaguaac     2760

aucaugguga aagacgaugg acagcuguuu cauauagauu uuggacacuu uuuggaucac     2820

aagaagaaaa aauuugguua uaaacgagaa cgugugccau uuguuuugac acaggauuuc     2880

uuaauaguga uuaguaaagg agcccaagaa ugcacaaaga caagagaauu ugagagguuu     2940

caggagaugu guuacaaggc uuaucuagcu auucgacagc augccaaucu cuucauaaau     3000

cuuuucucaa ugaugcuugg cucuggaaug ccagaacuac aaucuuuuga ugacauugca     3060

uacauucgaa agacccuagc cuuagauaaa acugagcaag aggcuuugga guauuucaug     3120

aaacaaauga augaugcaca ucaugguggc uggacaacaa aaauggauug gaucuuccac     3180

acaauuaaac agcaugcauu gaacuga                                         3207


<210>  9209
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAB39753

<400>  9209
augcccccgc gccccagcuc cggcgagcug ugggggaucc accucaugcc gccccggauc       60

cugguggagu gccugcuccc caacggcaug aucgucaccc uggagugccu gcgcgaggcc      120

acccucauca cgaucaagca cgagcuguuc aaggaggccc ggaaguaccc ccugcaccag      180

cuccugcagg acgagagcuc cuacaucuuc gugagcguga cccaggaggc ggagcgcgag      240

gaguucuucg acgagacccg gcgccugugc gaccuccggc uguuccagcc cuuccugaag      300

gucaucgagc ccguggggaa ccgcgaggag aagauccuca accgggagau cggcuucgcc      360

aucgggaugc cggugugcga guucgacaug gucaaggacc ccgaggugca ggacuuccgc      420

cggaacaucc ugaacgugug caaggaggcc gucgaccugc gcgaccucaa cagcccccac      480

agccgggcca uguacgugua cccgcccaac guggagucca gccccgagcu gcccaagcac      540

aucuacaaca agcuggacaa gggccagauc aucgucguga ucugggugau cgucuccccc      600

aacaacgaca agcagaagua cacccucaag aucaaccacg acugcgugcc ggagcagguc      660

aucgccgagg cgauccgcaa gaagacgcgg agcaugcugc uguccagcga gcagcucaag      720

cugugcgugc uggaguacca gggcaaguac auccucaagg ugugcgggug cgacgaguac      780

uuccuggaga aguacccccu gucccaguac aaguacaucc gcagcugcau caugcucggc      840

cggaugccca accugaugcu gauggccaag gagucccucu acagccagcu gcccauggac      900

ugcuucacca ugccguccua cagccgccgg aucuccaccg ccacccccua caugaacggg      960

gagacgagca ccaagagccu gugggugauc aacuccgccc uccgcaucaa gauccugugc     1020

gcgaccuacg ucaacgugaa cauccgggac aucgacaaga ucuacgugcg caccggcauc     1080

uaccacgggg gcgagccccu gugcgacaac gucaacacgc agcgcgugcc cugcagcaac     1140

ccgcggugga acgaguggcu caacuacgac aucuacaucc ccgaccugcc ccgcgccgcc     1200

cggcugugcc ucuccaucug cagcgucaag ggccgcaagg gggccaagga ggagcacugc     1260

ccccuggccu ggggcaacau caaccuguuc gacuacaccg acacccucgu guccgggaag     1320

auggcgcuga accuguggcc ggugccccac ggccucgagg accugcugaa ccccaucggc     1380

gucaccggga gcaacccgaa caaggagacg cccugccugg agcucgaguu cgacugguuc     1440

uccagcgugg ugaaguuccc cgacaugucc gucaucgagg agcacgccaa cuggagcgug     1500

ucccgggagg ccggcuucag cuacucccac gccgggcuga gcaaccgccu ggcccgggac     1560

aacgagcucc gcgagaacga caaggagcag cugaaggcga ucuccacccg ggacccccug     1620

agcgagauca ccgagcagga gaaggacuuc cucugguccc accgccacua cugcgugacc     1680

aucccggaga uccugcccaa gcugcuccug agcgucaagu ggaacucccg ggacgaggug     1740

gcccagaugu acugccuggu gaaggacugg ccgcccauca agcccgagca ggccauggag     1800

cuccuggacu gcaacuaccc cgaccccaug guccgcggcu ucgccgugcg gugccuggag     1860

aaguaccuca cggacgacaa gcugagccag uaccugaucc agcucgugca gguccugaag     1920

uacgagcagu accuggacaa ccuccuggug cgcuuccugc ucaagaaggc ccugaccaac     1980

cagcggaucg ggcacuucuu cuucuggcac cugaaguccg agaugcacaa caagaccgug     2040

ucccagcgcu ucggccuccu gcuggagagc uacugccggg cgugcggcau guaccucaag     2100

caccugaacc gccaggucga ggccauggag aagcugauca accucaccga cauccugaag     2160

caggagaaga aggacgagac gcagaaggug cagaugaagu uccuggugga gcagaugcgg     2220

cgccccgacu ucauggacgc ccuccagggg uuccuguccc cgcugaaccc cgcccaccag     2280

cucggcaacc ugcgccugga ggagugccgg aucaugagcu ccgccaagcg cccccucugg     2340

cugaacuggg agaaccccga caucaugagc gagcuccucu uccagaacaa cgagaucauc     2400

uucaagaacg gggacgaccu gcggcaggac augcugaccc uccagaucau ccgcaucaug     2460

gagaacaucu ggcagaacca gggccuggac cugcggaugc ucccguacgg gugccugucc     2520

aucggcgacu gcgucggccu gaucgaggug gugcgcaaca gccacaccau caugcagauc     2580

cagugcaagg gcgggcucaa gggggcgcug caguucaacu cccacacccu gcaccagugg     2640

cucaaggaca agaacaaggg cgagaucuac gacgccgcca ucgaccuguu cacgcggagc     2700

ugcgccgggu acugcgucgc gaccuucauc cugggcaucg gcgaccgcca caacuccaac     2760

aucaugguga aggacgacgg gcagcuguuc cacaucgacu ucggccacuu ccuggaccac     2820

aagaagaaga aguucgggua caagcgggag cgcgugcccu ucguccugac ccaggacuuc     2880

cucaucguga ucagcaaggg cgcccaggag ugcaccaaga cgcgggaguu cgagcgcuuc     2940

caggagaugu gcuacaaggc cuaccuggcc auccggcagc acgccaaccu guucaucaac     3000

cucuucucca ugaugcuggg cagcgggaug cccgagcugc aguccuucga cgacaucgcg     3060

uacauccgca agacccucgc ccuggacaag accgagcagg aggcccugga guacuucaug     3120

aagcagauga acgacgccca ccacggcggg uggaccacga agauggacug gaucuuccac     3180

accaucaagc agcacgcccu caacuga                                         3207


<210>  9210
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAB39753

<400>  9210
augccccccc gccccuccuc cggcgagcuc uggggcaucc accucaugcc cccccgcauc       60

cucgucgagu gccuccuccc caacggcaug aucgucaccc ucgagugccu ccgcgaggcc      120

acccucauca ccaucaagca cgagcucuuc aaggaggccc gcaaguaccc ccuccaccag      180

cuccuccagg acgaguccuc cuacaucuuc gucuccguca cccaggaggc cgagcgcgag      240

gaguucuucg acgagacccg ccgccucugc gaccuccgcc ucuuccagcc cuuccucaag      300

gucaucgagc ccgucggcaa ccgcgaggag aagauccuca accgcgagau cggcuucgcc      360

aucggcaugc ccgucugcga guucgacaug gucaaggacc ccgaggucca ggacuuccgc      420

cgcaacaucc ucaacgucug caaggaggcc gucgaccucc gcgaccucaa cuccccccac      480

ucccgcgcca uguacgucua cccccccaac gucgaguccu cccccgagcu ccccaagcac      540

aucuacaaca agcucgacaa gggccagauc aucgucguca ucugggucau cgucuccccc      600

aacaacgaca agcagaagua cacccucaag aucaaccacg acugcguccc cgagcagguc      660

aucgccgagg ccauccgcaa gaagacccgc uccaugcucc ucuccuccga gcagcucaag      720

cucugcgucc ucgaguacca gggcaaguac auccucaagg ucugcggcug cgacgaguac      780

uuccucgaga aguacccccu cucccaguac aaguacaucc gcuccugcau caugcucggc      840

cgcaugccca accucaugcu cauggccaag gagucccucu acucccagcu ccccauggac      900

ugcuucacca ugcccuccua cucccgccgc aucuccaccg ccacccccua caugaacggc      960

gagaccucca ccaagucccu cugggucauc aacuccgccc uccgcaucaa gauccucugc     1020

gccaccuacg ucaacgucaa cauccgcgac aucgacaaga ucuacguccg caccggcauc     1080

uaccacggcg gcgagccccu cugcgacaac gucaacaccc agcgcguccc cugcuccaac     1140

ccccgcugga acgaguggcu caacuacgac aucuacaucc ccgaccuccc ccgcgccgcc     1200

cgccucugcc ucuccaucug cuccgucaag ggccgcaagg gcgccaagga ggagcacugc     1260

ccccucgccu ggggcaacau caaccucuuc gacuacaccg acacccucgu cuccggcaag     1320

auggcccuca accucuggcc cgucccccac ggccucgagg accuccucaa ccccaucggc     1380

gucaccggcu ccaaccccaa caaggagacc cccugccucg agcucgaguu cgacugguuc     1440

uccuccgucg ucaaguuccc cgacaugucc gucaucgagg agcacgccaa cugguccguc     1500

ucccgcgagg ccggcuucuc cuacucccac gccggccucu ccaaccgccu cgcccgcgac     1560

aacgagcucc gcgagaacga caaggagcag cucaaggcca ucuccacccg cgacccccuc     1620

uccgagauca ccgagcagga gaaggacuuc cucugguccc accgccacua cugcgucacc     1680

auccccgaga uccuccccaa gcuccuccuc uccgucaagu ggaacucccg cgacgagguc     1740

gcccagaugu acugccucgu caaggacugg ccccccauca agcccgagca ggccauggag     1800

cuccucgacu gcaacuaccc cgaccccaug guccgcggcu ucgccguccg cugccucgag     1860

aaguaccuca ccgacgacaa gcucucccag uaccucaucc agcucgucca gguccucaag     1920

uacgagcagu accucgacaa ccuccucguc cgcuuccucc ucaagaaggc ccucaccaac     1980

cagcgcaucg gccacuucuu cuucuggcac cucaaguccg agaugcacaa caagaccguc     2040

ucccagcgcu ucggccuccu ccucgagucc uacugccgcg ccugcggcau guaccucaag     2100

caccucaacc gccaggucga ggccauggag aagcucauca accucaccga cauccucaag     2160

caggagaaga aggacgagac ccagaagguc cagaugaagu uccucgucga gcagaugcgc     2220

cgccccgacu ucauggacgc ccuccagggc uuccucuccc cccucaaccc cgcccaccag     2280

cucggcaacc uccgccucga ggagugccgc aucauguccu ccgccaagcg cccccucugg     2340

cucaacuggg agaaccccga caucaugucc gagcuccucu uccagaacaa cgagaucauc     2400

uucaagaacg gcgacgaccu ccgccaggac augcucaccc uccagaucau ccgcaucaug     2460

gagaacaucu ggcagaacca gggccucgac cuccgcaugc uccccuacgg cugccucucc     2520

aucggcgacu gcgucggccu caucgagguc guccgcaacu cccacaccau caugcagauc     2580

cagugcaagg gcggccucaa gggcgcccuc caguucaacu cccacacccu ccaccagugg     2640

cucaaggaca agaacaaggg cgagaucuac gacgccgcca ucgaccucuu cacccgcucc     2700

ugcgccggcu acugcgucgc caccuucauc cucggcaucg gcgaccgcca caacuccaac     2760

aucaugguca aggacgacgg ccagcucuuc cacaucgacu ucggccacuu ccucgaccac     2820

aagaagaaga aguucggcua caagcgcgag cgcguccccu ucguccucac ccaggacuuc     2880

cucaucguca ucuccaaggg cgcccaggag ugcaccaaga cccgcgaguu cgagcgcuuc     2940

caggagaugu gcuacaaggc cuaccucgcc auccgccagc acgccaaccu cuucaucaac     3000

cucuucucca ugaugcucgg cuccggcaug cccgagcucc aguccuucga cgacaucgcc     3060

uacauccgca agacccucgc ccucgacaag accgagcagg aggcccucga guacuucaug     3120

aagcagauga acgacgccca ccacggcggc uggaccacca agauggacug gaucuuccac     3180

accaucaagc agcacgcccu caacuga                                         3207


<210>  9211
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAB39753

<400>  9211
augcccccua gaccaagcuc cggcgagcug ugggggaucc accucaugcc gcccaggauu       60

cuuguggaau gccuguugcc uaacggaaug auagucaccu uagagugucu gcgggaagcc      120

acacuaauca cuauuaagca ugaacucuuc aaagaagcuc gcaaguaccc acugcaccag      180

cuucugcaag acgagucuuc auauaucuuu guuaguguga cgcaggaggc agaacgagag      240

gaguucuuug augagacccg uagauugugc gaccucaggc uguuccagcc cuuucugaaa      300

guaauugagc cuguggguaa ucgggaagag aagauccuca accgcgaaau aggcuucgcc      360

aucgggaugc cagucuguga guuugauaug gugaaagacc ccgaaguuca ggauuucaga      420

aggaauauuu uaaacgugug caaggaggcg gucgaccugc gggaucuuaa uagcccucau      480

ucccgcgcua uguacgugua uccaccgaac guagagucuu cgcccgaauu gccuaagcac      540

aucuacaaua aacuggacaa gggacaaauu aucguuguga uaugggucau ugugucacca      600

aacaaugaua aacagaagua uacacuaaaa aucaaccaug acugugugcc cgagcagguc      660

auugccgaag caauccgaaa gaagacuaga agcaugcucc ugaguuccga gcagcuuaaa      720

cugugcguuu uggaauacca aggcaaguau auccucaaag ugugugguug cgaugaguac      780

uuucuggaga aguacccuuu aucucaguau aaauacauua ggagcuguau aaugcugggg      840

cggaugccaa aucucaugcu uauggccaag gaaucccugu auucacaguu gcccauggac      900

ugcuucacca ugccgaguua cagccgucgc aucucuacag cuaccccuua uaugaacgga      960

gagacuucca caaaaucacu auggguaauu aauagcgcac ugagaaucaa gauacucugu     1020

gccaccuacg ugaacgucaa uauuagggau aucgacaaga ucuaugugcg gacgggcauu     1080

uaccacggcg gggaaccccu gugcgacaac guuaacacuc agcgagugcc augcaguaau     1140

ccucgcugga acgaguggcu uaauuacgau aucuauauuc ccgaccugcc aagagcugcc     1200

agguuguguc ucucuauaug cuccgucaaa ggacggaagg gugcgaaaga agaacacugu     1260

ccccuggcau ggggcaacau caauuuauuu gauuacaccg acacacuggu gagcgggaag     1320

auggcccuaa accucuggcc uguaccacau ggacuggagg aucuuuugaa uccgauuggc     1380

guuacugguu cgaaccccaa uaaagaaacc ccuugccugg agcucgaguu cgacugguuu     1440

ucuuccgugg ucaaguuccc agauauguca gugaucgagg agcacgcuaa cuggaguguc     1500

agccgcgaag ccggguucuc cuauucucau gcaggacuga gcaauagacu ugcuagggac     1560

aacgagcugc gugaaaauga uaaggagcaa uugaaagcca ucucaacacg ggacccccuc     1620

agugaaauua ccgagcagga gaaggauuuu cugugguccc accgacacua cugugugacg     1680

auaccugaaa ucuuaccaaa acugcuacuc agcguuaagu ggaacucuag agacgaggug     1740

gcgcagaugu auugccuggu aaaagacugg cccccgauua agccugaaca agccauggag     1800

cuuuuggauu guaauuaccc agaccccaug gucaggggcu ucgcagugcg cugccuggaa     1860

aaguaucuca cugaugacaa acugucacag uacuuaaucc agcugguuca ggugcuuaag     1920

uacgagcaau auuuggauaa ccuccugguc cgguuucuac ugaaaaaggc ucucacaaac     1980

cagagaauug gccauuucuu uuucuggcac cugaaaagug agaugcauaa uaagaccgug     2040

agccagaggu uugggcuuuu gcuggaaucc uacugucgcg ccugcggaau guauuuaaag     2100

caccucaacc gacagguaga ggcuauggaa aaacugauca aucuuacuga cauacugaag     2160

caagagaaaa aggaugaaac acagaaagug cagaugaagu ucuugguuga gcagaugcgg     2220

cguccugacu uuauggaugc ccuccaaggu uuccugucuc cccuaaaccc agcacaucag     2280

cugggcaauc ucagacugga ggaauguagg aucaugucga gcgccaaacg cccucuuugg     2340

uugaacuggg agaaucccga cauuaugucc gaacuguuau uucagaacaa ugagaucauu     2400

uucaagaacg gggaugaccu ccggcaggau augcugaccc uucaaaucau aagaauuaug     2460

gagaauaucu ggcagaacca gggacuggac cuaaggaugc ucccauacgg cugccuguca     2520

auuggugacu gcgucggguu gaucgaagug gugcgaaaua gucacacgau aaugcaaauc     2580

caguguaagg gcggacugaa aggcgcuuua caguuuaacu cucacacccu ccaucagugg     2640

cugaaggaua aaaauaaggg ggagauuuau gacgcggcaa ucgaucuuuu cacacgcagc     2700

ugcgccggau acugugucgc uacuuucauu cuggguaucg gcgaccggca caacuccaac     2760

auaaugguua aagaugacgg gcaauuguuu cauauugauu ucggacacuu ucucgaccac     2820

aagaagaaaa aguucggcua uaaaagagaa agggugccgu uugugcugac ccaggauuuc     2880

cuaaucguaa ucucaaaggg ugcccaggag ugcacaaaaa cucgugaauu ugagcgcuuc     2940

caggagaugu guuacaaggc auaccuggcc auucggcaac augcuaaucu uuuuaucaac     3000

cucuucagca ugaugcuggg gucuggcaug ccugaauugc aguccuuuga cgauauugcc     3060

uauauaagaa agacccuggc auuagacaaa acagagcagg aagcgcucga guacuucaug     3120

aagcagauga augaugcuca ccauggaggc uggaccacua aaauggacug gaucuuucac     3180

acgauuaagc aacaugcccu gaacuga                                         3207


<210>  9212
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAB39753

<400>  9212
augcccccca gacccagcag cggcgagcug uggggcaucc accugaugcc ccccagaauc       60

cugguggagu gccugcugcc caacggcaug aucgugaccc uggagugccu gagagaggcc      120

acccugauca ccaucaagca cgagcuguuc aaggaggcca gaaaguaccc ccugcaccag      180

cugcugcagg acgagagcag cuacaucuuc gugagcguga cccaggaggc cgagagagag      240

gaguucuucg acgagaccag aagacugugc gaccugagac uguuccagcc cuuccugaag      300

gugaucgagc ccgugggcaa cagagaggag aagauccuga acagagagau cggcuucgcc      360

aucggcaugc ccgugugcga guucgacaug gugaaggacc ccgaggugca ggacuucaga      420

agaaacaucc ugaacgugug caaggaggcc guggaccuga gagaccugaa cagcccccac      480

agcagagcca uguacgugua cccccccaac guggagagca gccccgagcu gcccaagcac      540

aucuacaaca agcuggacaa gggccagauc aucgugguga ucugggugau cgugagcccc      600

aacaacgaca agcagaagua cacccugaag aucaaccacg acugcgugcc cgagcaggug      660

aucgccgagg ccaucagaaa gaagaccaga agcaugcugc ugagcagcga gcagcugaag      720

cugugcgugc uggaguacca gggcaaguac auccugaagg ugugcggcug cgacgaguac      780

uuccuggaga aguacccccu gagccaguac aaguacauca gaagcugcau caugcugggc      840

agaaugccca accugaugcu gauggccaag gagagccugu acagccagcu gcccauggac      900

ugcuucacca ugcccagcua cagcagaaga aucagcaccg ccacccccua caugaacggc      960

gagaccagca ccaagagccu gugggugauc aacagcgccc ugagaaucaa gauccugugc     1020

gccaccuacg ugaacgugaa caucagagac aucgacaaga ucuacgugag aaccggcauc     1080

uaccacggcg gcgagccccu gugcgacaac gugaacaccc agagagugcc cugcagcaac     1140

cccagaugga acgaguggcu gaacuacgac aucuacaucc ccgaccugcc cagagccgcc     1200

agacugugcc ugagcaucug cagcgugaag ggcagaaagg gcgccaagga ggagcacugc     1260

ccccuggccu ggggcaacau caaccuguuc gacuacaccg acacccuggu gagcggcaag     1320

auggcccuga accuguggcc cgugccccac ggccuggagg accugcugaa ccccaucggc     1380

gugaccggca gcaaccccaa caaggagacc cccugccugg agcuggaguu cgacugguuc     1440

agcagcgugg ugaaguuccc cgacaugagc gugaucgagg agcacgccaa cuggagcgug     1500

agcagagagg ccggcuucag cuacagccac gccggccuga gcaacagacu ggccagagac     1560

aacgagcuga gagagaacga caaggagcag cugaaggcca ucagcaccag agacccccug     1620

agcgagauca ccgagcagga gaaggacuuc cuguggagcc acagacacua cugcgugacc     1680

auccccgaga uccugcccaa gcugcugcug agcgugaagu ggaacagcag agacgaggug     1740

gcccagaugu acugccuggu gaaggacugg ccccccauca agcccgagca ggccauggag     1800

cugcuggacu gcaacuaccc cgaccccaug gugagaggcu ucgccgugag augccuggag     1860

aaguaccuga ccgacgacaa gcugagccag uaccugaucc agcuggugca ggugcugaag     1920

uacgagcagu accuggacaa ccugcuggug agauuccugc ugaagaaggc ccugaccaac     1980

cagagaaucg gccacuucuu cuucuggcac cugaagagcg agaugcacaa caagaccgug     2040

agccagagau ucggccugcu gcuggagagc uacugcagag ccugcggcau guaccugaag     2100

caccugaaca gacaggugga ggccauggag aagcugauca accugaccga cauccugaag     2160

caggagaaga aggacgagac ccagaaggug cagaugaagu uccuggugga gcagaugaga     2220

agacccgacu ucauggacgc ccugcagggc uuccugagcc cccugaaccc cgcccaccag     2280

cugggcaacc ugagacugga ggagugcaga aucaugagca gcgccaagag accccugugg     2340

cugaacuggg agaaccccga caucaugagc gagcugcugu uccagaacaa cgagaucauc     2400

uucaagaacg gcgacgaccu gagacaggac augcugaccc ugcagaucau cagaaucaug     2460

gagaacaucu ggcagaacca gggccuggac cugagaaugc ugcccuacgg cugccugagc     2520

aucggcgacu gcgugggccu gaucgaggug gugagaaaca gccacaccau caugcagauc     2580

cagugcaagg gcggccugaa gggcgcccug caguucaaca gccacacccu gcaccagugg     2640

cugaaggaca agaacaaggg cgagaucuac gacgccgcca ucgaccuguu caccagaagc     2700

ugcgccggcu acugcguggc caccuucauc cugggcaucg gcgacagaca caacagcaac     2760

aucaugguga aggacgacgg ccagcuguuc cacaucgacu ucggccacuu ccuggaccac     2820

aagaagaaga aguucggcua caagagagag agagugcccu ucgugcugac ccaggacuuc     2880

cugaucguga ucagcaaggg cgcccaggag ugcaccaaga ccagagaguu cgagagauuc     2940

caggagaugu gcuacaaggc cuaccuggcc aucagacagc acgccaaccu guucaucaac     3000

cuguucagca ugaugcuggg cagcggcaug cccgagcugc agagcuucga cgacaucgcc     3060

uacaucagaa agacccuggc ccuggacaag accgagcagg aggcccugga guacuucaug     3120

aagcagauga acgacgccca ccacggcggc uggaccacca agauggacug gaucuuccac     3180

accaucaagc agcacgcccu gaacuga                                         3207


<210>  9213
<211>  3207
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAB39753

<400>  9213
augcccccua gaccgagcuc cggcgagcug ugggggaucc accucaugcc cccucggauu       60

cugguggaau gccuucugcc caacggaaug aucgucaccc ucgagugucu gcgcgaagcc      120

acacuuauua cgaucaagca ugagcuguuc aaagaagcua gaaaguaccc ucuccaccag      180

cugcugcaag acgagucuag cuauauuuuu guuuccguga cccaggaggc cgaacgggag      240

gaguucuuug augagacacg cagacucugc gaccugcggc uuuuccagcc cuuucugaaa      300

gugaucgagc cugucggcaa ucgcgaagag aagauccuca acagagaaau uggguucgcg      360

aucggaaugc cgguguguga guuugauaug guuaaagacc ccgaagugca ggauuuccgg      420

cgcaauauuc ugaacgucug caaggaggcu guggaccuua gagaucucaa uucuccucau      480

agccgggcca uguacguuua ucccccuaac guggaguccu cucccgaacu gccgaagcac      540

aucuacaaua aacuggacaa gggccaaauu aucgucguga uuugggugau cgucagcccu      600

aacaaugaua aacagaagua uacccugaaa aucaaccaug acuguguucc cgaacaggug      660

auugccgaag cuauccgcaa gaagacaaga uccaugcucc ugagcucuga gcagcuuaaa      720

cugugcgugc ucgaauacca agggaaguau auucugaaag ucuguggaug cgaugaguac      780

uuucuugaga aguacccucu gucccaguau aaauacaucc ggagcuguau uaugcucggc      840

cgcaugccca aucugaugcu gauggccaag gaaucucucu auucccagcu gcccauggac      900

ugcuucacca ugccuagcua cucuagacgg aucuccacag cuaccccgua uaugaacggc      960

gagacgagca ccaaaucccu uugggugauc aauucugccc ugagaauuaa gauccucugu     1020

gcgacauacg uuaacgugaa uauucgcgau aucgacaaga uuuauguccg gaccgggauc     1080

uaccacggag gcgaaccccu gugcgacaac gugaacacac agagaguucc uugcagcaau     1140

ccccgcugga acgaguggcu uaauuacgau aucuauauuc cugaccugcc ccgggccgcu     1200

agacucuguc uguccaucug cagcgugaaa gggcgcaagg gagccaaaga agaacacugu     1260

ccgcuggcuu ggggcaacau uaaucucuuu gauuacaccg acacgcuggu cucugggaag     1320

auggcccuua accuguggcc ugugccccau ggacucgagg aucugcugaa uccuaucggc     1380

gucacaggcu ccaaccccaa uaaagaaacc ccuugccuug agcucgaguu cgacugguuu     1440

agcucugugg uuaaguuccc cgauaugagc gugauugagg agcacgcgaa cugguccguc     1500

ucucgggaag ccggguucag cuauucccau gcuggacuga gcaauagacu ggcccgcgac     1560

aacgagcucc gggaaaauga uaaggagcaa cugaaagcua ucucuacaag agacccgcuu     1620

uccgaaauua ccgagcagga gaaggauuuu cuguggagcc accgccacua cugugugacc     1680

aucccugaaa uccuccccaa acugcugcuu ucuguuaagu ggaacucccg ggacgaggug     1740

gcccagaugu auugccucgu caaagacugg cccccuauua agccggaaca agccauggag     1800

cugcuggauu guaauuaccc cgacccuaug gugagaggcu ucgcugugcg gugccucgaa     1860

aaguaucuga cagaugacaa acuuagccag uaccugaucc agcucguuca gguccugaag     1920

uacgagcaau aucuggauaa ccuucucgug cgcuuucugc ugaaaaaggc gcucacgaac     1980

cagagaauug ggcauuucuu uuucuggcac cugaaauccg agaugcauaa uaagaccgug     2040

ucucagcggu uuggacuucu gcucgaaagc uacuguagag ccugcggcau guaucugaag     2100

caccugaacc gccaggucga ggcuauggaa aaacuuauca aucucacaga cauucugaag     2160

caagagaaaa aggaugaaac ccagaaagug cagaugaagu uccugguuga gcagaugcgg     2220

agacccgacu uuauggaugc ccuccaaggg uuccuguccc cucuuaaccc cgcccaucag     2280

cugggaaauc uccgccugga ggaauguaga aucaugucua gcgcuaaacg gccucugugg     2340

cuuaacuggg agaaucccga caucaugucc gaacugcucu uucagaacaa ugagauuauc     2400

uucaagaacg gcgaugaccu gcgccaggau augcucacac ugcaaauuau cagaauuaug     2460

gagaauaucu ggcagaacca gggccuugac cugcggaugc ucccguacgg gugccugagc     2520

aucggagacu gcgugggccu gauugaaguc gugcgcaauu cucacaccau caugcaaauu     2580

caguguaaag ggggacuuaa gggcgcccug caguuuaacu cccacacgcu ccaucagugg     2640

cugaaggaua aaaauaaggg ggagaucuau gacgcggcua uugaucucuu cacaagaagc     2700

ugcgccggcu acuguguugc caccuucauc cugggaaucg gcgaccggca caacucuaac     2760

auuaugguga aagaugacgg gcaacuuuuu cauaucgauu ucggacacuu ucuggaccac     2820

aagaagaaaa aguucggcua uaaacgcgaa agagucccuu uugugcucac ccaggauuuc     2880

cugauuguua ucuccaaggg ggcucaggag ugcacaaaaa cccgggaauu ugagcgcuuc     2940

caggagaugu guuacaaggc cuaccuggcu auuagacaac augccaaucu uuuuaucaac     3000

cuguucagca ugaugcucgg aucuggcaug cccgaacugc agagcuuuga cgauauugcg     3060

uauauccgga agacacucgc ccuggacaaa acggagcagg aagcucuuga guacuucaug     3120

aagcagauga augaugccca ccaugggggc uggaccacaa aaauggacug gaucuuucac     3180

accauuaagc aacaugcucu gaacuga                                         3207


<210>  9214
<211>  1070
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__P42338

<400>  9214

Met Cys Phe Ser Phe Ile Met Pro Pro Ala Met Ala Asp Ile Leu Asp 
1               5                   10                  15      


Ile Trp Ala Val Asp Ser Gln Ile Ala Ser Asp Gly Ser Ile Pro Val 
            20                  25                  30          


Asp Phe Leu Leu Pro Thr Gly Ile Tyr Ile Gln Leu Glu Val Pro Arg 
        35                  40                  45              


Glu Ala Thr Ile Ser Tyr Ile Lys Gln Met Leu Trp Lys Gln Val His 
    50                  55                  60                  


Asn Tyr Pro Met Phe Asn Leu Leu Met Asp Ile Asp Ser Tyr Met Phe 
65                  70                  75                  80  


Ala Cys Val Asn Gln Thr Ala Val Tyr Glu Glu Leu Glu Asp Glu Thr 
                85                  90                  95      


Arg Arg Leu Cys Asp Val Arg Pro Phe Leu Pro Val Leu Lys Leu Val 
            100                 105                 110         


Thr Arg Ser Cys Asp Pro Gly Glu Lys Leu Asp Ser Lys Ile Gly Val 
        115                 120                 125             


Leu Ile Gly Lys Gly Leu His Glu Phe Asp Ser Leu Lys Asp Pro Glu 
    130                 135                 140                 


Val Asn Glu Phe Arg Arg Lys Met Arg Lys Phe Ser Glu Glu Lys Ile 
145                 150                 155                 160 


Leu Ser Leu Val Gly Leu Ser Trp Met Asp Trp Leu Lys Gln Thr Tyr 
                165                 170                 175     


Pro Pro Glu His Glu Pro Ser Ile Pro Glu Asn Leu Glu Asp Lys Leu 
            180                 185                 190         


Tyr Gly Gly Lys Leu Ile Val Ala Val His Phe Glu Asn Cys Gln Asp 
        195                 200                 205             


Val Phe Ser Phe Gln Val Ser Pro Asn Met Asn Pro Ile Lys Val Asn 
    210                 215                 220                 


Glu Leu Ala Ile Gln Lys Arg Leu Thr Ile His Gly Lys Glu Asp Glu 
225                 230                 235                 240 


Val Ser Pro Tyr Asp Tyr Val Leu Gln Val Ser Gly Arg Val Glu Tyr 
                245                 250                 255     


Val Phe Gly Asp His Pro Leu Ile Gln Phe Gln Tyr Ile Arg Asn Cys 
            260                 265                 270         


Val Met Asn Arg Ala Leu Pro His Phe Ile Leu Val Glu Cys Cys Lys 
        275                 280                 285             


Ile Lys Lys Met Tyr Glu Gln Glu Met Ile Ala Ile Glu Ala Ala Ile 
    290                 295                 300                 


Asn Arg Asn Ser Ser Asn Leu Pro Leu Pro Leu Pro Pro Lys Lys Thr 
305                 310                 315                 320 


Arg Ile Ile Ser His Val Trp Glu Asn Asn Asn Pro Phe Gln Ile Val 
                325                 330                 335     


Leu Val Lys Gly Asn Lys Leu Asn Thr Glu Glu Thr Val Lys Val His 
            340                 345                 350         


Val Arg Ala Gly Leu Phe His Gly Thr Glu Leu Leu Cys Lys Thr Ile 
        355                 360                 365             


Val Ser Ser Glu Val Ser Gly Lys Asn Asp His Ile Trp Asn Glu Pro 
    370                 375                 380                 


Leu Glu Phe Asp Ile Asn Ile Cys Asp Leu Pro Arg Met Ala Arg Leu 
385                 390                 395                 400 


Cys Phe Ala Val Tyr Ala Val Leu Asp Lys Val Lys Thr Lys Lys Ser 
                405                 410                 415     


Thr Lys Thr Ile Asn Pro Ser Lys Tyr Gln Thr Ile Arg Lys Ala Gly 
            420                 425                 430         


Lys Val His Tyr Pro Val Ala Trp Val Asn Thr Met Val Phe Asp Phe 
        435                 440                 445             


Lys Gly Gln Leu Arg Thr Gly Asp Ile Ile Leu His Ser Trp Ser Ser 
    450                 455                 460                 


Phe Pro Asp Glu Leu Glu Glu Met Leu Asn Pro Met Gly Thr Val Gln 
465                 470                 475                 480 


Thr Asn Pro Tyr Thr Glu Asn Ala Thr Ala Leu His Val Lys Phe Pro 
                485                 490                 495     


Glu Asn Lys Lys Gln Pro Tyr Tyr Tyr Pro Pro Phe Asp Lys Ile Ile 
            500                 505                 510         


Glu Lys Ala Ala Glu Ile Ala Ser Ser Asp Ser Ala Asn Val Ser Ser 
        515                 520                 525             


Arg Gly Gly Lys Lys Phe Leu Pro Val Leu Lys Glu Ile Leu Asp Arg 
    530                 535                 540                 


Asp Pro Leu Ser Gln Leu Cys Glu Asn Glu Met Asp Leu Ile Trp Thr 
545                 550                 555                 560 


Leu Arg Gln Asp Cys Arg Glu Ile Phe Pro Gln Ser Leu Pro Lys Leu 
                565                 570                 575     


Leu Leu Ser Ile Lys Trp Asn Lys Leu Glu Asp Val Ala Gln Leu Gln 
            580                 585                 590         


Ala Leu Leu Gln Ile Trp Pro Lys Leu Pro Pro Arg Glu Ala Leu Glu 
        595                 600                 605             


Leu Leu Asp Phe Asn Tyr Pro Asp Gln Tyr Val Arg Glu Tyr Ala Val 
    610                 615                 620                 


Gly Cys Leu Arg Gln Met Ser Asp Glu Glu Leu Ser Gln Tyr Leu Leu 
625                 630                 635                 640 


Gln Leu Val Gln Val Leu Lys Tyr Glu Pro Phe Leu Asp Cys Ala Leu 
                645                 650                 655     


Ser Arg Phe Leu Leu Glu Arg Ala Leu Gly Asn Arg Arg Ile Gly Gln 
            660                 665                 670         


Phe Leu Phe Trp His Leu Arg Ser Glu Val His Ile Pro Ala Val Ser 
        675                 680                 685             


Val Gln Phe Gly Val Ile Leu Glu Ala Tyr Cys Arg Gly Ser Val Gly 
    690                 695                 700                 


His Met Lys Val Leu Ser Lys Gln Val Glu Ala Leu Asn Lys Leu Lys 
705                 710                 715                 720 


Thr Leu Asn Ser Leu Ile Lys Leu Asn Ala Val Lys Leu Asn Arg Ala 
                725                 730                 735     


Lys Gly Lys Glu Ala Met His Thr Cys Leu Lys Gln Ser Ala Tyr Arg 
            740                 745                 750         


Glu Ala Leu Ser Asp Leu Gln Ser Pro Leu Asn Pro Cys Val Ile Leu 
        755                 760                 765             


Ser Glu Leu Tyr Val Glu Lys Cys Lys Tyr Met Asp Ser Lys Met Lys 
    770                 775                 780                 


Pro Leu Trp Leu Val Tyr Asn Asn Lys Val Phe Gly Glu Asp Ser Val 
785                 790                 795                 800 


Gly Val Ile Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr 
                805                 810                 815     


Leu Gln Met Leu Arg Leu Met Asp Leu Leu Trp Lys Glu Ala Gly Leu 
            820                 825                 830         


Asp Leu Arg Met Leu Pro Tyr Gly Cys Leu Ala Thr Gly Asp Arg Ser 
        835                 840                 845             


Gly Leu Ile Glu Val Val Ser Thr Ser Glu Thr Ile Ala Asp Ile Gln 
    850                 855                 860                 


Leu Asn Ser Ser Asn Val Ala Ala Ala Ala Ala Phe Asn Lys Asp Ala 
865                 870                 875                 880 


Leu Leu Asn Trp Leu Lys Glu Tyr Asn Ser Gly Asp Asp Leu Asp Arg 
                885                 890                 895     


Ala Ile Glu Glu Phe Thr Leu Ser Cys Ala Gly Tyr Cys Val Ala Ser 
            900                 905                 910         


Tyr Val Leu Gly Ile Gly Asp Arg His Ser Asp Asn Ile Met Val Lys 
        915                 920                 925             


Lys Thr Gly Gln Leu Phe His Ile Asp Phe Gly His Ile Leu Gly Asn 
    930                 935                 940                 


Phe Lys Ser Lys Phe Gly Ile Lys Arg Glu Arg Val Pro Phe Ile Leu 
945                 950                 955                 960 


Thr Tyr Asp Phe Ile His Val Ile Gln Gln Gly Lys Thr Gly Asn Thr 
                965                 970                 975     


Glu Lys Phe Gly Arg Phe Arg Gln Cys Cys Glu Asp Ala Tyr Leu Ile 
            980                 985                 990         


Leu Arg Arg His Gly Asn Leu Phe Ile Thr Leu Phe Ala Leu Met Leu 
        995                 1000                1005            


Thr Ala Gly Leu Pro Glu Leu Thr Ser Val Lys Asp Ile Gln Tyr Leu 
    1010                1015                1020                


Lys Asp Ser Leu Ala Leu Gly Lys Ser Glu Glu Glu Ala Leu Lys Gln 
1025                1030                1035                1040


Phe Lys Gln Lys Phe Asp Glu Ala Leu Arg Glu Ser Trp Thr Thr Lys 
                1045                1050                1055    


Val Asn Trp Met Ala His Thr Val Arg Lys Asp Tyr Arg Ser 
            1060                1065                1070


<210>  9215
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAB29081

<400>  9215
augugcuuca guuucauaau gccuccugcu auggcagaca uccuugacau cugggcggug       60

gauucacaga uagcaucuga uggcuccaua ccuguggauu uccuuuugcc cacugggauu      120

uauauccagu uggagguacc ucgggaagcu accauuucuu auauuaagca gauguuaugg      180

aagcaaguuc acaauuaccc aauguucaac cuccuuaugg auauugacuc cuauauguuu      240

gcauguguga aucagacugc uguauaugag gagcuugaag augaaacacg aagacucugu      300

gaugucagac cuuuucuucc aguucucaaa uuagugacaa gaaguuguga cccaggggaa      360

aaauuagacu caaaaauugg aguccuuaua ggaaaagguc ugcaugaauu ugauuccuug      420

aaggauccug aaguaaauga auuucgaaga aaaaugcgca aauucagcga ggaaaaaauc      480

cugucacuug ugggauuguc uuggauggac uggcuaaaac aaacauaucc accagagcau      540

gaaccaucca ucccugaaaa cuuagaagau aaacuuuaug ggggaaagcu caucguagcu      600

guucauuuug aaaacugcca ggacguguuu agcuuucaag ugucuccuaa uaugaauccu      660

aucaaaguaa augaauuggc aauccaaaaa cguuugacua uucaugggaa ggaagaugaa      720

guuagccccu augauuaugu guugcaaguc agcgggagag uagaauaugu uuuuggugau      780

cauccacuaa uucaguucca guauauccgg aacuguguga ugaacagagc ccugccccau      840

uuuauacuug uggaaugcug caagaucaag aaaauguaug aacaagaaau gauugccaua      900

gaggcugcca uaaaucgaaa uucaucuaau cuuccucuuc cauuaccacc aaagaaaaca      960

cgaauuauuu cucauguuug ggaaaauaac aacccuuucc aaauugucuu gguuaaggga     1020

aauaaacuua acacagagga aacuguaaaa guucauguca gggcuggucu uuuucauggu     1080

acugagcucc uguguaaaac caucguaagc ucagagguau cagggaaaaa ugaucauauu     1140

uggaaugaac cacuggaauu ugauauuaau auuugugacu uaccaagaau ggcucgauua     1200

uguuuugcug uuuaugcagu uuuggauaaa guaaaaacga agaaaucaac gaaaacuauu     1260

aaucccucua aauaucagac caucaggaaa gcuggaaaag ugcauuaucc uguagcgugg     1320

guaaauacga ugguuuuuga cuuuaaagga caauugagaa cuggagacau aauauuacac     1380

agcuggucuu cauuuccuga ugaacucgaa gaaauguuga auccaauggg aacuguucaa     1440

acaaauccau auacugaaaa ugcaacagcu uugcauguua aauuuccaga gaauaaaaaa     1500

caaccuuauu auuacccucc cuucgauaag auuauugaaa aggcagcuga gauugcaagc     1560

agugauagug cuaauguguc aagucgaggu ggaaaaaagu uucuuccugu auugaaagaa     1620

aucuuggaca gggaucccuu gucucaacug ugugaaaaug aaauggaucu uauuuggacu     1680

uugcgacaag acugccgaga gauuuuccca caaucacugc caaaauuacu gcugucaauc     1740

aaguggaaua aacuugagga uguugcucag cuucaggcgc ugcuucagau uuggccuaaa     1800

cugccccccc gggaggcccu agagcuucug gauuucaacu auccagacca guacguucga     1860

gaauaugcug uaggcugccu gcgacagaug agugaugaag aacuuucuca auaucuuuua     1920

caacuggugc aaguguuaaa auaugagccu uuucuugauu gugcccucuc uagauuccua     1980

uuagaaagag cacuugguaa ucggaggaua gggcaguuuc uauuuuggca ucuuagguca     2040

gaagugcaca uuccugcugu cucaguacaa uuugguguca uccuugaagc auacugccgg     2100

ggaagugugg ggcacaugaa agugcuuucu aagcagguug aagcacucaa uaaguuaaaa     2160

acuuuaaaua guuuaaucaa acugaaugcc gugaaguuaa acagagccaa agggaaggag     2220

gccaugcaua ccuguuuaaa acagagugcu uaccgggaag cccucucuga ccugcaguca     2280

ccccugaacc cauguguuau ccucucagaa cucuauguug aaaagugcaa auacauggau     2340

uccaaaauga agccuuugug gcugguauac aauaacaagg uauuugguga ggauucaguu     2400

ggagugauuu uuaaaaaugg ugaugauuua cgacaggaua uguugacacu ccaaauguug     2460

cgcuugaugg auuuacucug gaaagaagcu gguuuggauc uucggauguu gccuuauggc     2520

uguuuagcaa caggagaucg cucuggccuc auugaaguug ugagcaccuc ugaaacaauu     2580

gcugacauuc agcugaacag uagcaaugug gcugcugcag cagccuucaa caaagaugcc     2640

cuucugaacu ggcuuaaaga auacaacucu ggggaugacc uggaccgagc cauugaggaa     2700

uuuacacugu ccugugcugg cuacugugua gcuucuuaug uccuugggau uggugacaga     2760

cauagugaca acaucauggu caaaaaaacu ggccagcucu uccacauuga cuuuggacau     2820

auucuuggaa auuucaaauc uaaguuuggc auuaaaaggg agcgagugcc uuuuauucuu     2880

accuaugauu ucauccaugu cauucaacaa ggaaaaacag gaaauacaga aaaguuuggc     2940

cgguuccgcc aguguuguga ggaugcauau cugauuuuac gacggcaugg gaaucucuuc     3000

aucacucucu uugcgcugau guugacugca gggcuuccug aacucacauc agucaaagau     3060

auacaguauc uuaaggacuc ucuugcauua gggaagagug aagaagaagc acucaaacag     3120

uuuaagcaaa aauuugauga ggcgcucagg gaaagcugga cuacuaaagu gaacuggaug     3180

gcccacacag uucggaaaga cuacagaucu uaa                                  3213


<210>  9216
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAB29081

<400>  9216
augugcuuca gcuucaucau gcccccggcc auggccgaca uccuggacau cugggcggug       60

gacucccaga ucgccagcga cggcuccauc cccgucgacu uccuccugcc caccgggauc      120

uacauccagc uggaggugcc ccgcgaggcc accaucagcu acaucaagca gaugcucugg      180

aagcaggucc acaacuaccc gauguucaac cugcugaugg acaucgacuc cuacauguuc      240

gccugcguga accagacggc cguguacgag gagcucgagg acgagacccg gcgccugugc      300

gacgugcggc ccuuccugcc cguccucaag cuggugaccc gcagcugcga ccccggcgag      360

aagcuggacu ccaagaucgg ggugcucauc ggcaaggggc ugcacgaguu cgacagccug      420

aaggacccgg aggucaacga guuccggcgc aagaugcgga aguucuccga ggagaagauc      480

cucagccugg ugggccuguc cuggauggac uggcucaagc agaccuaccc gcccgagcac      540

gagcccagca uccccgagaa ccuggaggac aagcuguacg gcgggaagcu caucguggcg      600

guccacuucg agaacugcca ggacguguuc uccuuccagg ugagccccaa caugaacccc      660

aucaagguca acgagcuggc cauccagaag cgccugacga uccacggcaa ggaggacgag      720

gugucccccu acgacuacgu gcuccagguc agcgggcggg uggaguacgu guucggcgac      780

cacccgcuga uccaguucca guacauccgc aacugcguca ugaaccgggc ccugccccac      840

uucauccucg uggagugcug caagaucaag aagauguacg agcaggagau gaucgccauc      900

gaggcggcca ucaaccgcaa cuccagcaac cugccccugc cccucccgcc caagaagacc      960

cggaucaucu cccacgugug ggagaacaac aaccccuucc agaucguccu ggugaagggg     1020

aacaagcuga acaccgagga gaccgucaag gugcacgugc gcgccggccu cuuccacggc     1080

acggagcugc ugugcaagac caucgucagc agcgaggugu ccgggaagaa cgaccacauc     1140

uggaacgagc cccucgaguu cgacaucaac aucugcgacc ugccgcggau ggcccgccug     1200

ugcuucgccg uguacgcggu ccucgacaag gugaagacca agaaguccac caagacgauc     1260

aaccccagca aguaccagac cauccggaag gccggcaagg ugcacuaccc cgucgccugg     1320

gugaacacca ugguguucga cuucaagggg cagcugcgca ccggcgacau cauccugcac     1380

agcuggucca gcuuccccga cgagcucgag gagaugcuga acccgauggg cacgguccag     1440

accaaccccu acaccgagaa cgccaccgcc cugcacguga aguuccccga gaacaagaag     1500

cagccguacu acuacccgcc cuucgacaag aucaucgaga aggcggccga gaucgccucc     1560

agcgacuccg ccaacgugag cucccgcggg ggcaagaagu uccuccccgu ccugaaggag     1620

auccuggacc gggacccccu cagccagcug ugcgagaacg agauggaccu gaucuggacg     1680

cugcggcagg acugccgcga gaucuucccc cagucccucc ccaagcugcu gcucagcauc     1740

aaguggaaca agcuggagga cguggcccag cugcaggcgc uccugcagau cuggcccaag     1800

cugccgcccc gcgaggcccu cgagcugcug gacuucaacu accccgacca guacgugcgg     1860

gaguacgccg ucgggugccu ccgccagaug uccgacgagg agcugagcca guaccugcuc     1920

cagcuggucc aggugcugaa guacgagccc uuccucgacu gcgcccuguc ccgguuccug     1980

cucgagcgcg cccugggcaa ccggcgcauc gggcaguucc uguucuggca ccuccggagc     2040

gaggugcaca ucccggcggu guccgugcag uucggcguca uccuggaggc cuacugccgc     2100

ggcagcgugg ggcacaugaa ggugcugagc aagcaggucg aggcccucaa caagcugaag     2160

acccugaacu cccucaucaa gcugaacgcc gugaagcuga accgggcgaa gggcaaggag     2220

gccaugcaca cgugccucaa gcagagcgcc uaccgcgagg cccuguccga ccugcagagc     2280

ccccucaacc ccugcgugau ccuguccgag cuguacgucg agaagugcaa guacauggac     2340

agcaagauga agccccucug gcugguguac aacaacaagg uguucgggga ggacuccguc     2400

ggcgugaucu ucaagaacgg ggacgaccug cggcaggaca ugcucacccu gcagaugcug     2460

cgccucaugg accugcugug gaaggaggcc ggccucgacc ugcggaugcu gccguacggc     2520

ugccucgcga cgggggaccg cagcggccug aucgaggugg ucuccaccag cgagaccauc     2580

gccgacaucc agcugaacuc cagcaacgug gccgccgccg cggccuucaa caaggacgcc     2640

cuccugaacu ggcugaagga guacaacucc ggggacgacc ucgaccgggc caucgaggag     2700

uucacccuga gcugcgccgg cuacugcgug gcguccuacg uccuggggau cggcgaccgc     2760

cacagcgaca acaucauggu gaagaagacg ggccagcugu uccacaucga cuucgggcac     2820

auccucggca acuucaaguc caaguucggg aucaagcggg agcgcgugcc cuucauccug     2880

accuacgacu ucauccacgu cauccagcag ggcaagaccg gcaacaccga gaaguucggg     2940

cgguuccgcc agugcugcga ggacgccuac cucauccugc gccggcacgg caaccuguuc     3000

aucacccucu ucgcccugau gcugaccgcc gggcuccccg agcugaccag cgugaaggac     3060

auccaguacc ugaaggacag ccucgcgcug ggcaaguccg aggaggaggc ccugaagcag     3120

uucaagcaga aguucgacga ggcccuccgc gagagcugga ccacgaaggu gaacuggaug     3180

gcccacaccg uccggaagga cuaccgcucc uga                                  3213


<210>  9217
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAB29081

<400>  9217
augugcuucu ccuucaucau gccccccgcc auggccgaca uccucgacau cugggccguc       60

gacucccaga ucgccuccga cggcuccauc cccgucgacu uccuccuccc caccggcauc      120

uacauccagc ucgagguccc ccgcgaggcc accaucuccu acaucaagca gaugcucugg      180

aagcaggucc acaacuaccc cauguucaac cuccucaugg acaucgacuc cuacauguuc      240

gccugcguca accagaccgc cgucuacgag gagcucgagg acgagacccg ccgccucugc      300

gacguccgcc ccuuccuccc cguccucaag cucgucaccc gcuccugcga ccccggcgag      360

aagcucgacu ccaagaucgg cguccucauc ggcaagggcc uccacgaguu cgacucccuc      420

aaggaccccg aggucaacga guuccgccgc aagaugcgca aguucuccga ggagaagauc      480

cucucccucg ucggccucuc cuggauggac uggcucaagc agaccuaccc ccccgagcac      540

gagcccucca uccccgagaa ccucgaggac aagcucuacg gcggcaagcu caucgucgcc      600

guccacuucg agaacugcca ggacgucuuc uccuuccagg ucucccccaa caugaacccc      660

aucaagguca acgagcucgc cauccagaag cgccucacca uccacggcaa ggaggacgag      720

gucucccccu acgacuacgu ccuccagguc uccggccgcg ucgaguacgu cuucggcgac      780

cacccccuca uccaguucca guacauccgc aacugcguca ugaaccgcgc ccucccccac      840

uucauccucg ucgagugcug caagaucaag aagauguacg agcaggagau gaucgccauc      900

gaggccgcca ucaaccgcaa cuccuccaac cucccccucc cccucccccc caagaagacc      960

cgcaucaucu cccacgucug ggagaacaac aaccccuucc agaucguccu cgucaagggc     1020

aacaagcuca acaccgagga gaccgucaag guccacgucc gcgccggccu cuuccacggc     1080

accgagcucc ucugcaagac caucgucucc uccgaggucu ccggcaagaa cgaccacauc     1140

uggaacgagc cccucgaguu cgacaucaac aucugcgacc ucccccgcau ggcccgccuc     1200

ugcuucgccg ucuacgccgu ccucgacaag gucaagacca agaaguccac caagaccauc     1260

aaccccucca aguaccagac cauccgcaag gccggcaagg uccacuaccc cgucgccugg     1320

gucaacacca uggucuucga cuucaagggc cagcuccgca ccggcgacau cauccuccac     1380

uccugguccu ccuuccccga cgagcucgag gagaugcuca accccauggg caccguccag     1440

accaaccccu acaccgagaa cgccaccgcc cuccacguca aguuccccga gaacaagaag     1500

cagcccuacu acuacccccc cuucgacaag aucaucgaga aggccgccga gaucgccucc     1560

uccgacuccg ccaacgucuc cucccgcggc ggcaagaagu uccuccccgu ccucaaggag     1620

auccucgacc gcgacccccu cucccagcuc ugcgagaacg agauggaccu caucuggacc     1680

cuccgccagg acugccgcga gaucuucccc cagucccucc ccaagcuccu ccucuccauc     1740

aaguggaaca agcucgagga cgucgcccag cuccaggccc uccuccagau cuggcccaag     1800

cucccccccc gcgaggcccu cgagcuccuc gacuucaacu accccgacca guacguccgc     1860

gaguacgccg ucggcugccu ccgccagaug uccgacgagg agcucuccca guaccuccuc     1920

cagcucgucc agguccucaa guacgagccc uuccucgacu gcgcccucuc ccgcuuccuc     1980

cucgagcgcg cccucggcaa ccgccgcauc ggccaguucc ucuucuggca ccuccgcucc     2040

gagguccaca uccccgccgu cuccguccag uucggcguca uccucgaggc cuacugccgc     2100

ggcuccgucg gccacaugaa gguccucucc aagcaggucg aggcccucaa caagcucaag     2160

acccucaacu cccucaucaa gcucaacgcc gucaagcuca accgcgccaa gggcaaggag     2220

gccaugcaca ccugccucaa gcaguccgcc uaccgcgagg cccucuccga ccuccagucc     2280

ccccucaacc ccugcgucau ccucuccgag cucuacgucg agaagugcaa guacauggac     2340

uccaagauga agccccucug gcucgucuac aacaacaagg ucuucggcga ggacuccguc     2400

ggcgucaucu ucaagaacgg cgacgaccuc cgccaggaca ugcucacccu ccagaugcuc     2460

cgccucaugg accuccucug gaaggaggcc ggccucgacc uccgcaugcu ccccuacggc     2520

ugccucgcca ccggcgaccg cuccggccuc aucgaggucg ucuccaccuc cgagaccauc     2580

gccgacaucc agcucaacuc cuccaacguc gccgccgccg ccgccuucaa caaggacgcc     2640

cuccucaacu ggcucaagga guacaacucc ggcgacgacc ucgaccgcgc caucgaggag     2700

uucacccucu ccugcgccgg cuacugcguc gccuccuacg uccucggcau cggcgaccgc     2760

cacuccgaca acaucauggu caagaagacc ggccagcucu uccacaucga cuucggccac     2820

auccucggca acuucaaguc caaguucggc aucaagcgcg agcgcguccc cuucauccuc     2880

accuacgacu ucauccacgu cauccagcag ggcaagaccg gcaacaccga gaaguucggc     2940

cgcuuccgcc agugcugcga ggacgccuac cucauccucc gccgccacgg caaccucuuc     3000

aucacccucu ucgcccucau gcucaccgcc ggccuccccg agcucaccuc cgucaaggac     3060

auccaguacc ucaaggacuc ccucgcccuc ggcaaguccg aggaggaggc ccucaagcag     3120

uucaagcaga aguucgacga ggcccuccgc gaguccugga ccaccaaggu caacuggaug     3180

gcccacaccg uccgcaagga cuaccgcucc uga                                  3213


<210>  9218
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAB29081

<400>  9218
augugcuuca gcuuuaucau gcccccugcc auggcugaca uucuggauau augggcagug       60

gacucccaga ucgccucuga uggcucaauu ccagucgacu uccuccuucc gaccgggauc      120

uacauucaac uggagguucc cagagaagcg acaaucaguu auauaaagca gauguugugg      180

aaacaggugc acaacuaccc uauguuuaau uuacugaugg auaucgacag cuauauguuc      240

gcuuguguaa accagacugc cguguacgag gaacuagagg augaaacgag gcggcucugc      300

gacguccgcc cauuucugcc cgugcuuaag cugguuaccc gauccuguga uccuggagag      360

aaauuggacu cuaagauugg ugugcucauc ggcaaagggc ugcaugaguu cgauucgcug      420

aaggacccag aagucaauga guuucguaga aagaugagga aauucucaga agagaagauu      480

cucagcuuag ugggacugag uuggauggau uggcuuaaac aaacauaucc cccugagcac      540

gaaccaucca ucccggagaa cuuggaagac aagcuguacg gcgguaaacu aauaguagca      600

guucauuuug agaauugcca ggacguguuc ucuuuucagg ucagccccaa caugaauccu      660

auuaagguga acgaacucgc cauccagaag cggcugacua uucacgggaa agaggaugag      720

guguccccau augacuacgu ccuucaaguu ucaggacgcg uggaauacgu auucggcgau      780

cauccccuga uccaguuuca guauaucaga aauuguguga ugaacagggc uuugccucac      840

uucauucucg ucgagugcug uaagaucaaa aagauguacg aacaggagau gauagcaauu      900

gaagccgcua ucaaucggaa caguagcaau cugccauuac cccugccgcc uaaaaagacc      960

cgcauaauuu cucacgugug ggagaacaau aaccccuucc aaaucguucu cgugaaaggc     1020

aacaaguuga auacagagga aaccgucaag gugcauguac gagccgggcu guuucacgga     1080

acugaguugc uaugcaaaac aaucguuucc ucagaaguga gcgguaagaa cgaccauauu     1140

uggaaugagc cacuggaguu cgauaucaac auuugugacc ucccuagaau ggcgaggcug     1200

ugcuuugcag ucuaugccgu gcuugauaaa gucaagacca aaaagaguac gaagacuaua     1260

aaucccucua aauaccagac cauccggaag gcuggcaaag ugcacuaucc aguugccugg     1320

gugaacacaa ugguauucga cuuuaagggg cagcugcgua cuggagauau uaucuugcac     1380

uccuggagcu cguuccccga cgaacucgag gaaaugcuga auccuauggg caccguccaa     1440

acaaacccau acaccgagaa ugcaacggcu uuacauguga aauuuccgga aaacaagaag     1500

cagcccuauu acuacccucc auucgauaaa aucauugaga aggccgcgga gauagccucu     1560

uccgacucag caaauguuag uagccgcggu gggaaaaagu uucugcccgu gcuaaaagaa     1620

auccucgaca gagauccucu gucccagcuu ugugagaacg aaauggacuu gauuuggacu     1680

cugaggcagg auugccggga gaucuuccca caaucucucc ccaagcugcu ucugagcauu     1740

aaguggaaua aauuggaaga cgucgcucag cuccaggccc uguuacagau cuggccgaag     1800

cugccuccac gagaggcucu agagcuccug gauuuuaacu aucccgacca auacgugcgc     1860

gaauaugccg uaggaugccu uagacagaug ucagaugagg aauugaguca guaccugcuc     1920

cagcuggugc aaguuuuaaa auaugagccu uuccuggacu gugcacuuuc cagguuuuug     1980

cucgaacggg cccugggcaa ucgcagaaua ggccaguucc uauucuggca ccugaggagc     2040

gagguccaua uccccgcugu gucugugcag uuugggguca uucucgaggc guacugccgu     2100

ggaucaguug gucacaugaa ggugcugagu aaacaggugg aagcacuuaa caaguugaaa     2160

acacugaaca gcuuaaucaa gcucaaugcc guaaagcuga accgggcuaa aggcaaggag     2220

gccaugcaua ccugucuuaa acaauccgca uaucgagaag cccugucuga uuugcagucg     2280

ccacucaauc cuugcgucau ucugagcgag cuauacgugg aaaaguguaa auacauggac     2340

uccaagauga agccccugug gcucguuuau aacaauaaag uguucgggga ggauucaguc     2400

ggagugaucu uuaagaacgg cgacgaucug agacaggaca ugcuuacuuu gcaaaugcug     2460

agguuaaugg accuccugug gaaagaggcu ggucuugauc ugcgcaugcu accauacggg     2520

ugccucgcca caggcgaccg gaguggacug auagaaguug ugucuaccag cgagacgauu     2580

gcagauaucc agcuuaauuc cucaaacgua gcggcugccg cagccuucaa uaaggacgcu     2640

cuguuaaacu ggcucaaaga auauaauagc ggcgaugacc uggauagagc cauugaggag     2700

uuuacccuuu cuugugcagg guacugcguc gcuuccuaug ugcugggaau cggugacagg     2760

cacagugaua acauaauggu gaagaagaca ggccaguugu uccacaucga cuuugggcau     2820

auucucggaa auuucaaaag caaguuuggc aucaaacgcg aacgaguccc guucauucug     2880

acuuacgauu uuauccacgu uauacagcaa gguaagaccg ggaacacaga gaaauucggc     2940

cgguuucguc aguguugcga agacgccuau cuaauucuga gaaggcaugg aaaucuuuuc     3000

aucacucucu ucgcgcugau guugaccgcc ggccugccug aguuaacauc ugugaaggau     3060

auccaguacc ucaaggacuc ccuggcucuu gggaaaucag aagaggaggc acugaagcag     3120

uuuaaacaaa aguucgacga agccuugcgc gagaguugga ccacuaaagu aaacuggaug     3180

gcucacacgg ugcggaagga uuacagaagc uga                                  3213


<210>  9219
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAB29081

<400>  9219
augugcuuca gcuucaucau gccccccgcc auggccgaca uccuggacau cugggccgug       60

gacagccaga ucgccagcga cggcagcauc cccguggacu uccugcugcc caccggcauc      120

uacauccagc uggaggugcc cagagaggcc accaucagcu acaucaagca gaugcugugg      180

aagcaggugc acaacuaccc cauguucaac cugcugaugg acaucgacag cuacauguuc      240

gccugcguga accagaccgc cguguacgag gagcuggagg acgagaccag aagacugugc      300

gacgugagac ccuuccugcc cgugcugaag cuggugacca gaagcugcga ccccggcgag      360

aagcuggaca gcaagaucgg cgugcugauc ggcaagggcc ugcacgaguu cgacagccug      420

aaggaccccg aggugaacga guucagaaga aagaugagaa aguucagcga ggagaagauc      480

cugagccugg ugggccugag cuggauggac uggcugaagc agaccuaccc ccccgagcac      540

gagcccagca uccccgagaa ccuggaggac aagcuguacg gcggcaagcu gaucguggcc      600

gugcacuucg agaacugcca ggacguguuc agcuuccagg ugagccccaa caugaacccc      660

aucaagguga acgagcuggc cauccagaag agacugacca uccacggcaa ggaggacgag      720

gugagccccu acgacuacgu gcugcaggug agcggcagag uggaguacgu guucggcgac      780

cacccccuga uccaguucca guacaucaga aacugcguga ugaacagagc ccugccccac      840

uucauccugg uggagugcug caagaucaag aagauguacg agcaggagau gaucgccauc      900

gaggccgcca ucaacagaaa cagcagcaac cugccccugc cccugccccc caagaagacc      960

agaaucauca gccacgugug ggagaacaac aaccccuucc agaucgugcu ggugaagggc     1020

aacaagcuga acaccgagga gaccgugaag gugcacguga gagccggccu guuccacggc     1080

accgagcugc ugugcaagac caucgugagc agcgagguga gcggcaagaa cgaccacauc     1140

uggaacgagc cccuggaguu cgacaucaac aucugcgacc ugcccagaau ggccagacug     1200

ugcuucgccg uguacgccgu gcuggacaag gugaagacca agaagagcac caagaccauc     1260

aaccccagca aguaccagac caucagaaag gccggcaagg ugcacuaccc cguggccugg     1320

gugaacacca ugguguucga cuucaagggc cagcugagaa ccggcgacau cauccugcac     1380

agcuggagca gcuuccccga cgagcuggag gagaugcuga accccauggg caccgugcag     1440

accaaccccu acaccgagaa cgccaccgcc cugcacguga aguuccccga gaacaagaag     1500

cagcccuacu acuacccccc cuucgacaag aucaucgaga aggccgccga gaucgccagc     1560

agcgacagcg ccaacgugag cagcagaggc ggcaagaagu uccugcccgu gcugaaggag     1620

auccuggaca gagacccccu gagccagcug ugcgagaacg agauggaccu gaucuggacc     1680

cugagacagg acugcagaga gaucuucccc cagagccugc ccaagcugcu gcugagcauc     1740

aaguggaaca agcuggagga cguggcccag cugcaggccc ugcugcagau cuggcccaag     1800

cugcccccca gagaggcccu ggagcugcug gacuucaacu accccgacca guacgugaga     1860

gaguacgccg ugggcugccu gagacagaug agcgacgagg agcugagcca guaccugcug     1920

cagcuggugc aggugcugaa guacgagccc uuccuggacu gcgcccugag cagauuccug     1980

cuggagagag cccugggcaa cagaagaauc ggccaguucc uguucuggca ccugagaagc     2040

gaggugcaca uccccgccgu gagcgugcag uucggcguga uccuggaggc cuacugcaga     2100

ggcagcgugg gccacaugaa ggugcugagc aagcaggugg aggcccugaa caagcugaag     2160

acccugaaca gccugaucaa gcugaacgcc gugaagcuga acagagccaa gggcaaggag     2220

gccaugcaca ccugccugaa gcagagcgcc uacagagagg cccugagcga ccugcagagc     2280

ccccugaacc ccugcgugau ccugagcgag cuguacgugg agaagugcaa guacauggac     2340

agcaagauga agccccugug gcugguguac aacaacaagg uguucggcga ggacagcgug     2400

ggcgugaucu ucaagaacgg cgacgaccug agacaggaca ugcugacccu gcagaugcug     2460

agacugaugg accugcugug gaaggaggcc ggccuggacc ugagaaugcu gcccuacggc     2520

ugccuggcca ccggcgacag aagcggccug aucgaggugg ugagcaccag cgagaccauc     2580

gccgacaucc agcugaacag cagcaacgug gccgccgccg ccgccuucaa caaggacgcc     2640

cugcugaacu ggcugaagga guacaacagc ggcgacgacc uggacagagc caucgaggag     2700

uucacccuga gcugcgccgg cuacugcgug gccagcuacg ugcugggcau cggcgacaga     2760

cacagcgaca acaucauggu gaagaagacc ggccagcugu uccacaucga cuucggccac     2820

auccugggca acuucaagag caaguucggc aucaagagag agagagugcc cuucauccug     2880

accuacgacu ucauccacgu gauccagcag ggcaagaccg gcaacaccga gaaguucggc     2940

agauucagac agugcugcga ggacgccuac cugauccuga gaagacacgg caaccuguuc     3000

aucacccugu ucgcccugau gcugaccgcc ggccugcccg agcugaccag cgugaaggac     3060

auccaguacc ugaaggacag ccuggcccug ggcaagagcg aggaggaggc ccugaagcag     3120

uucaagcaga aguucgacga ggcccugaga gagagcugga ccaccaaggu gaacuggaug     3180

gcccacaccg ugagaaagga cuacagaagc uga                                  3213


<210>  9220
<211>  3213
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAB29081

<400>  9220
augugcuuca gcuuuaucau gcccccugcc auggcugaca uucuggauau cugggccgug       60

gacucccaga uugcgucuga uggcagcauc ccggucgacu uccuccugcc caccgggauu      120

uacauccaac uugagguucc uagagaagcu acaaucuccu auauuaagca gaugcugugg      180

aaacaggugc acaacuaccc cauguuuaau cuccugaugg auaucgacuc uuauauguuc      240

gccuguguga accagacggc cgucuacgag gaacuugagg augaaacccg gcgccugugc      300

gacgugagac cuuuucuccc cguucugaag cuggugacac ggagcuguga uccuggagag      360

aaacucgacu ccaagauugg cguccugauc gggaaaggac uucaugaguu cgauucucug      420

aaggacccgg aagugaauga guuucgcaga aagaugcgga aauucagcga agagaagauu      480

cucucccugg uuggccuuag cuggauggau uggcugaaac aaaccuaucc cccugagcac      540

gaacccucua ucccugagaa ccucgaagac aagcuguacg ggggaaaacu gauuguggcu      600

guccauuuug agaauugcca ggacguguuc uccuuucagg ugagccccaa caugaauccg      660

aucaagguca acgaacucgc cauccagaag cgccugacaa uucacggcaa agaggaugag      720

guuucuccuu augacuacgu gcuucaagug uccggcagag ucgaauacgu guucggggau      780

cauccccuga uccaguuuca guauauucgg aauuguguua ugaaccgcgc ucucccucac      840

uucauccugg uggagugcug uaagauuaaa aagauguacg aacaggagau gaucgccauc      900

gaagcggcca uuaauagaaa cagcucuaau cuuccccugc cccucccucc gaaaaagacc      960

cggaucauuu cccacgucug ggagaacaau aaccccuucc aaaucgugcu gguuaaagga     1020

aacaagcuga auacagagga aaccgugaag guccaugugc gcgcuggccu cuuucacggg     1080

acggagcugc uuugcaaaac cauugucagc uccgaagugu cuggaaagaa cgaccauauc     1140

uggaaugagc cucuggaguu cgauaucaac auuugugacc uccccagaau ggcccggcug     1200

ugcuuugcug uuuaugccgu gcuugauaaa gucaagacca aaaagagcac aaagacaauc     1260

aauccuucca aauaccagac cauucgcaag gcgggcaaag ugcacuaucc cguugccugg     1320

gugaacacga uggucuucga cuuuaagggg cagcugagaa caggagauau cauucuccac     1380

agcuggucuu ccuucccgga cgaacuggag gaaaugcuga auccuauggg caccgugcaa     1440

acaaaccccu acaccgagaa ugcuaccgcc cuccauguga aauuuccuga aaacaagaag     1500

cagcccuauu acuacccucc cuucgauaaa aucauugaga aggcugccga gaucgccagc     1560

ucugacagcg cuaauguuuc cucucggggc gggaaaaagu uucugccggu ccuuaaagaa     1620

auccuggaca gagauccucu cagccagcug ugugagaacg aaauggaccu gauuuggaca     1680

cuucgccagg auugccggga gaucuucccc caaucccucc ccaagcugcu gcucagcauu     1740

aaguggaaua aacuggaaga cguggcgcag cuucaggccc ugcuccagau cuggccuaag     1800

cugccgccca gagaggcucu ggagcuucuc gauuuuaacu auccugacca auacgugcgc     1860

gaauaugccg ucggaugccu gcggcagaug ucugaugagg aacuguccca guaccuccug     1920

cagcuugugc aaguucugaa auaugagccc uuccucgacu gugcccugag cagauuucug     1980

cuugaacgcg cucucggcaa ucggagaauu gggcaguucc uguucuggca ucugcgcucu     2040

gaggugcaca ucccugccgu cuccgugcag uuuggaguua uccucgaggc guacugccgg     2100

ggcagcgugg ggcacaugaa gguccugucc aaacaggugg aagcucuuaa caagcugaaa     2160

acgcucaacu cucugauuaa gcugaaugcc guuaagcuga acagagccaa aggaaaggag     2220

gcuaugcaua ccugucucaa acaaagcgcc uaucgcgaag cucuguccga ucugcagucu     2280

ccccucaauc cuugcgugau ccugagcgag cuuuacgucg aaaaguguaa auacauggac     2340

uccaagauga agccccugug gcucguguau aacaauaaag uguucggcga ggauagcguc     2400

ggcguuauuu uuaagaacgg ggacgaucug cggcaggaca ugcugacacu ucaaaugcug     2460

agacucaugg accugcucug gaaagaggcc ggacuggauc uucggaugcu gccguacggc     2520

ugccucgcga ccggggaccg cucuggacug aucgaagugg uguccacaag cgagaccauu     2580

gccgauaucc agcuuaauuc uuccaacguc gcugccgcug ccgcguucaa uaaggacgcc     2640

cuucugaacu ggcucaaaga auauaauagc ggcgaugacc uggauagagc uaucgaggag     2700

uuuacgcucu cuugugccgg guacugcgug gcuagcuaug uucugggcau uggagaccgg     2760

cacuccgaua acaucauggu gaagaagaca ggccagcuuu uccacauuga cuuugggcau     2820

auccugggaa auuucaaaag caaguuuggc auuaaaagag aacgcguccc uuucauccuc     2880

accuacgauu uuauccacgu gauucagcaa gggaagaccg gaaacacaga gaaauucggc     2940

cgguuuagac aguguugcga agacgccuau cugauccugc gcagacaugg gaaucuuuuc     3000

auuacccugu ucgcccucau gcugacagcu ggccuccccg agcugacguc uguuaaggau     3060

auccaguacc uuaaggacuc ccuggcgcug ggaaaaagcg aagaggaggc ccucaagcag     3120

uuuaaacaaa aguucgacga agcucugcgg gaguccugga ccacaaaagu gaacuggaug     3180

gcccacaccg uccgcaagga uuacagaucu uga                                  3213


<210>  9221
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__P48736

<400>  9221

Met Glu Leu Glu Asn Tyr Lys Gln Pro Val Val Leu Arg Glu Asp Asn 
1               5                   10                  15      


Cys Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Ala Ser Leu 
            20                  25                  30          


Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln 
        35                  40                  45              


Arg Lys Cys Lys Ser Pro Glu Thr Ala Leu Leu His Val Ala Gly His 
    50                  55                  60                  


Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu 
65                  70                  75                  80  


Thr Ser Val Ala Ala Asp Phe Tyr His Arg Leu Gly Pro His His Phe 
                85                  90                  95      


Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Lys 
            100                 105                 110         


Tyr Gln Val Val Gln Thr Leu Asp Cys Leu Arg Tyr Trp Lys Ala Thr 
        115                 120                 125             


His Arg Ser Pro Gly Gln Ile His Leu Val Gln Arg His Pro Pro Ser 
    130                 135                 140                 


Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly Tyr 
145                 150                 155                 160 


Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr 
                165                 170                 175     


Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg Asp 
            180                 185                 190         


Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro 
        195                 200                 205             


Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile 
    210                 215                 220                 


His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp Thr 
225                 230                 235                 240 


Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys 
                245                 250                 255     


Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val Leu 
            260                 265                 270         


Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile Lys 
        275                 280                 285             


Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile His 
    290                 295                 300                 


Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys 
305                 310                 315                 320 


Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His 
                325                 330                 335     


Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val 
            340                 345                 350         


Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile 
        355                 360                 365             


Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu 
    370                 375                 380                 


Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser 
385                 390                 395                 400 


Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe 
                405                 410                 415     


Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln 
            420                 425                 430         


Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala Glu 
        435                 440                 445             


Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Gln Leu Leu Tyr Tyr Val 
    450                 455                 460                 


Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu Tyr 
465                 470                 475                 480 


Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly Ser 
                485                 490                 495     


Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn 
            500                 505                 510         


Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala 
        515                 520                 525             


Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg 
    530                 535                 540                 


Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala 
545                 550                 555                 560 


Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp 
                565                 570                 575     


His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu 
            580                 585                 590         


Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr 
        595                 600                 605             


Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp Val 
    610                 615                 620                 


Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val 
625                 630                 635                 640 


Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val 
                645                 650                 655     


Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr 
            660                 665                 670         


His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn 
        675                 680                 685             


Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala 
    690                 695                 700                 


Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr 
705                 710                 715                 720 


Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln Val 
                725                 730                 735     


Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser Leu 
            740                 745                 750         


Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys 
        755                 760                 765             


Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe Arg 
    770                 775                 780                 


Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu Lys 
785                 790                 795                 800 


Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys 
                805                 810                 815     


Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe 
            820                 825                 830         


Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu 
        835                 840                 845             


Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu 
    850                 855                 860                 


Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu 
865                 870                 875                 880 


Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr Val 
                885                 890                 895     


Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys 
            900                 905                 910         


Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe 
        915                 920                 925             


Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile 
    930                 935                 940                 


Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn Leu 
945                 950                 955                 960 


Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu 
                965                 970                 975     


Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu 
            980                 985                 990         


Phe Val Met Gly Thr Ser Gly Lys Lys Thr Ser Pro His Phe Gln Lys 
        995                 1000                1005            


Phe Gln Asp Ile Cys Val Lys Ala Tyr Leu Ala Leu Arg His His Thr 
    1010                1015                1020                


Asn Leu Leu Ile Ile Leu Phe Ser Met Met Leu Met Thr Gly Met Pro 
1025                1030                1035                1040


Gln Leu Thr Ser Lys Glu Asp Ile Glu Tyr Ile Arg Asp Ala Leu Thr 
                1045                1050                1055    


Val Gly Lys Asn Glu Glu Asp Ala Lys Lys Tyr Phe Leu Asp Gln Ile 
            1060                1065                1070        


Glu Val Cys Arg Asp Lys Gly Trp Thr Val Gln Phe Asn Trp Phe Leu 
        1075                1080                1085            


His Leu Val Leu Gly Ile Lys Gln Gly Glu Lys His Ser Ala 
    1090                1095                1100        


<210>  9222
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAH35683

<400>  9222
auggagcugg agaacuauaa acagcccgug gugcugagag aggacaacug ccgaaggcgc       60

cggaggauga agccgcgcag ugcugcggcc agccuguccu ccauggagcu cauccccauc      120

gaguucgugc ugcccaccag ccagcgcaaa ugcaagagcc ccgaaacggc gcugcugcac      180

guggccggcc acggcaacgu ggagcagaug aaggcccagg uguggcugcg agcgcuggag      240

accagcgugg cggcggacuu cuaccaccgg cugggaccgc aucacuuccu ccugcucuau      300

cagaagaagg ggcaguggua cgagaucuac gacaaguacc agguggugca gacucuggac      360

ugccugcgcu acuggaaggc cacgcaccgg agcccgggcc agauccaccu ggugcagcgg      420

cacccgcccu ccgaggaguc ccaagccuuc cagcggcagc ucacggcgcu gauuggcuau      480

gacgucacug acgucagcaa cgugcacgac gaugagcugg aguucacgcg ccguggcuug      540

gugaccccgc gcauggcgga gguggccagc cgcgacccca agcucuacgc caugcacccg      600

ugggugacgu ccaagccccu cccggaguac cuguggaaga agauugccaa caacugcauc      660

uucaucguca uucaccgcag caccaccagc cagaccauua aggucucacc cgacgacacc      720

cccggcgcca uccugcagag cuucuucacc aagauggcca agaagaaauc ucugauggau      780

auucccgaaa gccaaagcga acaggauuuu gugcugcgcg ucuguggccg ggaugaguac      840

cuggugggcg aaacgcccau caaaaacuuc caguggguga ggcacugccu caagaacgga      900

gaagagauuc acgugguacu ggacacgccu ccagacccgg cccuagacga ggugaggaag      960

gaagaguggc cgcuggugga cgacugcacg ggagucaccg gcuaccauga gcagcuuacc     1020

auccacggca aggaccacga gaguguguuc accguguccc ugugggacug cgaccgcaag     1080

uucaggguca agaucagagg cauugauauc cccguccugc cucggaacac cgaccucaca     1140

guuuuuguag aggcaaacau ccagcauggg caacaagucc uuugccaaag gagaaccagc     1200

cccaaacccu ucacagagga ggugcugugg aauguguggc uugaguucag uaucaaaauc     1260

aaagacuugc ccaaaggggc ucuacugaac cuccagaucu acugcgguaa agcuccagca     1320

cuguccagca aggccucugc agaguccccc aguucugagu ccaagggcaa aguucagcuu     1380

cucuauuaug ugaaccugcu gcugauagac caccguuucc uccugcgccg uggagaauac     1440

guccuccaca uguggcagau aucugggaag ggagaagacc aaggaagcuu caaugcugac     1500

aaacucacgu cugcaacuaa cccagacaag gagaacucaa uguccaucuc cauucuucug     1560

gacaauuacu gccacccgau agcccugccu aagcaucagc ccaccccuga cccggaaggg     1620

gaccggguuc gagcagaaau gcccaaccag cuucgcaagc aauuggaggc gaucauagcc     1680

acugauccac uuaacccucu cacagcagag gacaaagaau ugcucuggca uuuuagauac     1740

gaaagccuua agcacccaaa agcauauccu aagcuauuua guucagugaa auggggacag     1800

caagaaauug uggccaaaac auaccaauug uuggccagaa gggaagucug ggaucaaagu     1860

gcuuuggaug uuggguuaac aaugcagcuc cuggacugca acuucucaga ugaaaaugua     1920

agagccauug caguucagaa acuggagagc uuggaggacg augauguucu gcauuaccuu     1980

cuacaauugg uccaggcugu gaaauuugaa ccauaccaug auagugcccu ugccagauuu     2040

cugcugaagc gugguuuaag aaacaaaaga auuggucacu uuuuguuuug guucuugaga     2100

agugagauag cccaguccag acacuaucag cagagguucg cugugauucu ggaagccuau     2160

cugaggggcu guggcacagc caugcugcac gacuuuaccc aacaagucca aguaaucgag     2220

auguuacaaa aagucacccu ugauauuaaa ucgcucucug cugaaaagua ugacgucagu     2280

ucccaaguua uuucacaacu uaaacaaaag cuugaaaacc ugcagaauuc ucaacucccc     2340

gaaagcuuua gaguuccaua ugauccugga cugaaagcag gagcgcuggc aauugaaaaa     2400

uguaaaguaa uggccuccaa gaaaaaacca cuauggcuug aguuuaaaug ugccgauccu     2460

acagcccuau caaaugaaac aauuggaauu aucuuuaaac auggugauga ucugcgccaa     2520

gacaugcuua uuuuacagau ucuacgaauc auggagucua uuugggagac ugaaucuuug     2580

gaucuaugcc uccugccaua ugguugcauu ucaacuggug acaaaauagg aaugaucgag     2640

auugugaaag acgccacgac aauugccaaa auucagcaaa gcacaguggg caacacggga     2700

gcauuuaaag augaaguccu gaaucacugg cucaaagaaa aauccccuac ugaagaaaag     2760

uuucaggcag caguggagag auuuguuuau uccugugcag gcuacugugu ggcaaccuuu     2820

guucuuggaa uaggcgacag acacaaugac aauauuauga ucaccgagac aggaaaccua     2880

uuucauauug acuucgggca cauucuuggg aauuacaaaa guuuccuggg cauuaauaaa     2940

gagagagugc cauuugugcu aaccccugac uuccucuuug ugaugggaac uucuggaaag     3000

aagacaagcc cacacuucca gaaauuucag gacaucugug uuaaggcuua ucuagcccuu     3060

cgucaucaca caaaccuacu gaucauccug uucuccauga ugcugaugac aggaaugccc     3120

caguuaacaa gcaaagaaga cauugaauau auccgggaug cccucacagu ggggaaaaau     3180

gaggaggaug cuaaaaagua uuuucuugau cagaucgaag uuugcagaga caaaggaugg     3240

acugugcagu uuaauugguu ucuacaucuu guucuuggca ucaaacaagg agagaaacau     3300

ucagccuaa                                                             3309


<210>  9223
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAH35683

<400>  9223
auggagcugg agaacuacaa gcagcccgug guccuccgcg aggacaacug ccggcgccgg       60

cgccggauga agccgcgcag cgccgccgcg ucccugagcu ccauggagcu gauccccauc      120

gaguucgugc uccccaccag ccagcggaag ugcaaguccc ccgagaccgc ccugcugcac      180

guggccggcc acgggaacgu cgagcagaug aaggcccagg uguggcuccg cgcccuggag      240

acgagcgugg cggccgacuu cuaccaccgg cugggcccgc accacuuccu ccugcuguac      300

cagaagaagg ggcaguggua cgagaucuac gacaaguacc aggucgugca gacccucgac      360

ugccugcgcu acuggaaggc cacccaccgg ucccccggcc agauccaccu ggugcagcgc      420

cacccgccca gcgaggaguc ccaggccuuc cagcggcagc ucaccgcgcu gaucggguac      480

gacgucacgg acgugagcaa cgugcacgac gacgagcugg aguucacccg ccggggccuc      540

gucacgcccc gcauggccga gguggccucc cgggacccca agcuguacgc caugcacccc      600

ugggugacca gcaagccccu gccggaguac cucuggaaga agaucgccaa caacugcauc      660

uucaucguca uccaccgcuc caccaccagc cagaccauca aggugucccc cgacgacacc      720

cccggcgcga uccugcagag cuucuucacg aagauggcca agaagaaguc ccugauggac      780

auccccgaga gccaguccga gcaggacuuc gugcuccggg ucugcgggcg cgacgaguac      840

cuggugggcg agaccccgau caagaacuuc cagugggugc ggcacugccu gaagaacggg      900

gaggagaucc acgucgugcu cgacaccccg cccgaccccg cccuggacga ggugcgcaag      960

gaggaguggc cccuggucga cgacugcacc ggcgugacgg gguaccacga gcagcucacc     1020

auccacggca aggaccacga gagcgucuuc accgugagcc ugugggacug cgaccgcaag     1080

uuccggguga agauccgcgg caucgacauc cccguccugc cccggaacac cgaccucacg     1140

guguucgugg aggccaacau ccagcacggg cagcaggucc ugugccagcg ccggaccucc     1200

cccaagccgu ucaccgagga ggugcugugg aacguguggc ucgaguucag caucaagauc     1260

aaggaccugc ccaagggcgc ccugcucaac cugcagaucu acugcgggaa ggcgcccgcc     1320

cuguccagca aggccuccgc cgagagcccc uccagcgagu ccaagggcaa gguccagcuc     1380

cuguacuacg ugaaccugcu ccugaucgac caccgcuucc ugcuccggcg cggcgaguac     1440

gugcugcaca uguggcagau cagcgggaag ggcgaggacc agggguccuu caacgccgac     1500

aagcugacca gcgcgacgaa cccggacaag gagaacucca ugagcaucuc cauccugcuc     1560

gacaacuacu gccaccccau cgcccugccc aagcaccagc cgacccccga ccccgagggc     1620

gaccgggucc gcgccgagau gcccaaccag cugcggaagc agcucgaggc caucaucgcc     1680

accgacccgc ugaacccccu gaccgcggag gacaaggagc uccuguggca cuuccgcuac     1740

gagagccuga agcaccccaa ggccuacccc aagcuguucu ccagcgugaa gugggggcag     1800

caggagaucg uggccaagac guaccagcuc cuggcccggc gcgaggucug ggaccagucc     1860

gcgcucgacg ugggccugac caugcagcug cucgacugca acuucagcga cgagaacgug     1920

cgggccaucg ccguccagaa gcuggagagc cuggaggacg acgacgugcu ccacuaccug     1980

cugcagcucg ugcaggccgu caaguucgag ccguaccacg acuccgcccu ggcgcgcuuc     2040

cugcucaagc ggggccugcg caacaagcgg aucgggcacu uccuguucug guuccuccgc     2100

agcgagaucg cccagucccg ccacuaccag cagcgguucg ccgugauccu ggaggccuac     2160

cugcgcggcu gcgggaccgc caugcuccac gacuucaccc agcaggucca ggugaucgag     2220

augcugcaga aggugacgcu ggacaucaag agccucuccg cggagaagua cgacgugagc     2280

ucccagguca ucagccagcu gaagcagaag cuggagaacc uccagaacuc ccagcugccc     2340

gagagcuucc gggugcccua cgaccccggc cugaaggccg gggcccucgc caucgagaag     2400

ugcaagguga uggccuccaa gaagaagccg cuguggcugg aguucaagug cgcggacccc     2460

accgcccuca gcaacgagac caucggcauc aucuucaagc acggcgacga ccugcgccag     2520

gacaugcuga uccuccagau ccugcggauc auggagucca ucugggagac cgagagccug     2580

gaccucugcc ugcugcccua cgggugcauc uccacgggcg acaagaucgg gaugaucgag     2640

aucgucaagg acgccaccac caucgccaag auccagcaga gcaccguggg caacaccggg     2700

gcguucaagg acgaggugcu caaccacugg cugaaggaga agucccccac ggaggagaag     2760

uuccaggccg ccgucgagcg cuucguguac agcugcgccg gcuacugcgu ggccaccuuc     2820

guccugggca ucggggaccg gcacaacgac aacaucauga ucaccgagac cggcaaccuc     2880

uuccacaucg acuucgggca cauccugggc aacuacaaga gcuuccuggg caucaacaag     2940

gagcgcgugc cguucgugcu cacgcccgac uuccuguucg ucauggggac cuccggcaag     3000

aagaccagcc cccacuucca gaaguuccag gacaucugcg ugaaggcgua ccuggcccuc     3060

cggcaccaca ccaaccugcu gaucauccuc uucuccauga ugcugaugac ggggaugccc     3120

cagcugacca gcaaggagga caucgaguac auccgcgacg cccucaccgu gggcaagaac     3180

gaggaggacg ccaagaagua cuuccuggac cagaucgagg ucugccggga caaggggugg     3240

accgugcagu ucaacugguu ccugcaccuc gugcugggca ucaagcaggg cgagaagcac     3300

uccgccuga                                                             3309


<210>  9224
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAH35683

<400>  9224
auggagcucg agaacuacaa gcagcccguc guccuccgcg aggacaacug ccgccgccgc       60

cgccgcauga agccccgcuc cgccgccgcc ucccucuccu ccauggagcu cauccccauc      120

gaguucgucc uccccaccuc ccagcgcaag ugcaaguccc ccgagaccgc ccuccuccac      180

gucgccggcc acggcaacgu cgagcagaug aaggcccagg ucuggcuccg cgcccucgag      240

accuccgucg ccgccgacuu cuaccaccgc cucggccccc accacuuccu ccuccucuac      300

cagaagaagg gccaguggua cgagaucuac gacaaguacc aggucgucca gacccucgac      360

ugccuccgcu acuggaaggc cacccaccgc ucccccggcc agauccaccu cguccagcgc      420

cacccccccu ccgaggaguc ccaggccuuc cagcgccagc ucaccgcccu caucggcuac      480

gacgucaccg acgucuccaa cguccacgac gacgagcucg aguucacccg ccgcggccuc      540

gucacccccc gcauggccga ggucgccucc cgcgacccca agcucuacgc caugcacccc      600

ugggucaccu ccaagccccu ccccgaguac cucuggaaga agaucgccaa caacugcauc      660

uucaucguca uccaccgcuc caccaccucc cagaccauca aggucucccc cgacgacacc      720

cccggcgcca uccuccaguc cuucuucacc aagauggcca agaagaaguc ccucauggac      780

auccccgagu cccaguccga gcaggacuuc guccuccgcg ucugcggccg cgacgaguac      840

cucgucggcg agacccccau caagaacuuc cagugggucc gccacugccu caagaacggc      900

gaggagaucc acgucguccu cgacaccccc cccgaccccg cccucgacga gguccgcaag      960

gaggaguggc cccucgucga cgacugcacc ggcgucaccg gcuaccacga gcagcucacc     1020

auccacggca aggaccacga guccgucuuc accgucuccc ucugggacug cgaccgcaag     1080

uuccgcguca agauccgcgg caucgacauc cccguccucc cccgcaacac cgaccucacc     1140

gucuucgucg aggccaacau ccagcacggc cagcaggucc ucugccagcg ccgcaccucc     1200

cccaagcccu ucaccgagga gguccucugg aacgucuggc ucgaguucuc caucaagauc     1260

aaggaccucc ccaagggcgc ccuccucaac cuccagaucu acugcggcaa ggcccccgcc     1320

cucuccucca aggccuccgc cgaguccccc uccuccgagu ccaagggcaa gguccagcuc     1380

cucuacuacg ucaaccuccu ccucaucgac caccgcuucc uccuccgccg cggcgaguac     1440

guccuccaca uguggcagau cuccggcaag ggcgaggacc agggcuccuu caacgccgac     1500

aagcucaccu ccgccaccaa ccccgacaag gagaacucca uguccaucuc cauccuccuc     1560

gacaacuacu gccaccccau cgcccucccc aagcaccagc ccacccccga ccccgagggc     1620

gaccgcgucc gcgccgagau gcccaaccag cuccgcaagc agcucgaggc caucaucgcc     1680

accgaccccc ucaacccccu caccgccgag gacaaggagc uccucuggca cuuccgcuac     1740

gagucccuca agcaccccaa ggccuacccc aagcucuucu ccuccgucaa guggggccag     1800

caggagaucg ucgccaagac cuaccagcuc cucgcccgcc gcgaggucug ggaccagucc     1860

gcccucgacg ucggccucac caugcagcuc cucgacugca acuucuccga cgagaacguc     1920

cgcgccaucg ccguccagaa gcucgagucc cucgaggacg acgacguccu ccacuaccuc     1980

cuccagcucg uccaggccgu caaguucgag cccuaccacg acuccgcccu cgcccgcuuc     2040

cuccucaagc gcggccuccg caacaagcgc aucggccacu uccucuucug guuccuccgc     2100

uccgagaucg cccagucccg ccacuaccag cagcgcuucg ccgucauccu cgaggccuac     2160

cuccgcggcu gcggcaccgc caugcuccac gacuucaccc agcaggucca ggucaucgag     2220

augcuccaga aggucacccu cgacaucaag ucccucuccg ccgagaagua cgacgucucc     2280

ucccagguca ucucccagcu caagcagaag cucgagaacc uccagaacuc ccagcucccc     2340

gaguccuucc gcguccccua cgaccccggc cucaaggccg gcgcccucgc caucgagaag     2400

ugcaagguca uggccuccaa gaagaagccc cucuggcucg aguucaagug cgccgacccc     2460

accgcccucu ccaacgagac caucggcauc aucuucaagc acggcgacga ccuccgccag     2520

gacaugcuca uccuccagau ccuccgcauc auggagucca ucugggagac cgagucccuc     2580

gaccucugcc uccuccccua cggcugcauc uccaccggcg acaagaucgg caugaucgag     2640

aucgucaagg acgccaccac caucgccaag auccagcagu ccaccgucgg caacaccggc     2700

gccuucaagg acgagguccu caaccacugg cucaaggaga agucccccac cgaggagaag     2760

uuccaggccg ccgucgagcg cuucgucuac uccugcgccg gcuacugcgu cgccaccuuc     2820

guccucggca ucggcgaccg ccacaacgac aacaucauga ucaccgagac cggcaaccuc     2880

uuccacaucg acuucggcca cauccucggc aacuacaagu ccuuccucgg caucaacaag     2940

gagcgcgucc ccuucguccu cacccccgac uuccucuucg ucaugggcac cuccggcaag     3000

aagaccuccc cccacuucca gaaguuccag gacaucugcg ucaaggccua ccucgcccuc     3060

cgccaccaca ccaaccuccu caucauccuc uucuccauga ugcucaugac cggcaugccc     3120

cagcucaccu ccaaggagga caucgaguac auccgcgacg cccucaccgu cggcaagaac     3180

gaggaggacg ccaagaagua cuuccucgac cagaucgagg ucugccgcga caagggcugg     3240

accguccagu ucaacugguu ccuccaccuc guccucggca ucaagcaggg cgagaagcac     3300

uccgccuga                                                             3309


<210>  9225
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAH35683

<400>  9225
auggagcugg aaaacuacaa gcagcccgug guccucagag aggacaauug caggcggcgc       60

cgacguauga aaccuagaag cgccgcugca ucccuuucuu caauggaacu gaucccaauu      120

gaguucguuu ugccgaccag ucaaaggaag uguaaaagcc ccgaaacagc cuuacugcac      180

guggcgggcc augggaacgu agagcagaug aaggcucagg uguggcuacg ggcccucgag      240

acuuccgucg cagccgauuu uuaucaccgc cugggaccuc aucacuuccu ucuguuguac      300

cagaaaaagg gucaauggua ugaaauauac gacaaguauc aggugguuca gacgcucgau      360

ugccugagau acuggaaagc uacccauagg ucuccaggcc agauccaccu ggugcaacgg      420

caucccccuu cggaggaauc acaggcauuu cagcgccagc ucacagccuu aauuggguau      480

gacgucacug augugagcaa uguacacgac gaugagcugg aguucacccg aagaggacuu      540

guuacaccaa ggauggcuga aguggccagu cgggacccca aguuguacgc gaugcacccu      600

ugggucaccu ccaaaccacu gccggaguac cuauggaaga aaaucgcaaa caauuguauu      660

uuuaucguga uacaucguuc uacuacaagc caaaccauca aggugucccc cgaugacacg      720

ccuggcgcca uucuccaguc auucuuuacu aagauggcua aaaagaaaag ucugauggau      780

aucccagaaa gccagucuga gcaagacuuc guccuucgcg uuugcgguag agaugaauau      840

cugguggggg agacccccau uaagaacuuu caguggguaa ggcacuguuu gaaaaaugga      900

gaggaaaucc acgugguccu cgacacaccu ccagaccccg cccuggauga ggugcggaag      960

gaagaguggc cguuaguuga cgauugcacu ggcgugaccg gcuaccauga acagcugaca     1020

auacacggga aagaccauga guccgucuuc accgugucac ucugggauug ugaccgaaag     1080

uuucgcguaa agauuagagg aaucgauauu ccuguucuuc ccaggaacac ggaccugacu     1140

guguucgucg aggcaaauau ccagcacggu caacaggugu ugugccagcg gcgcacaagc     1200

ccaaaaccuu uuaccgaaga gguccuaugg aacguguggc uggaguucag uaucaagauu     1260

aaagaucucc ccaagggcgc ucugcuuaau cugcagauau auugugggaa agccccagcg     1320

uugucuucca aggccagcgc agaaucgccc ucuuccgaau caaagggaaa aguucaacuc     1380

cuguacuaug ugaacuuacu gcuaaucgac cauagauucc uccugaggcg uggcgaguac     1440

guacuucaca uguggcagau uagugguaag ggggaggauc agggcagcuu uaaugcugac     1500

aaauugacuu ccgccacaaa cccugacaag gaaaauucua ugagcaucuc aauacugcuc     1560

gauaacuauu gccacccaau ugcucugccg aaacaucagc ccaccccuga cccagaggga     1620

gaucgggucc gagccgaaau gcccaaccaa cuuagaaagc agcuggaggc aaucaucgcc     1680

acggacccuu ugaauccacu caccgcugag gauaaggaac uguuauggca cuucagguac     1740

gagagucuga aacaucccaa ggcguacccg aaacuauuuu ccagcgugaa guggggccag     1800

caggaaauug uugcaaaaac auaucaacuc cuggcccgcc gggaggugug ggaccagucu     1860

gcucuugaug ucggguugac uaugcagcug cucgacugua acuucucaga ugaaaaugug     1920

agagccaucg caguacaaaa gcuggagagu uuagaggacg augacgugcu gcacuaccuu     1980

uugcagcucg uucaggccgu caaguuugaa ccuuaucacg auagcgcucu ggccagguuc     2040

cuacugaaac gcggacuccg aaacaagcgg auuggucauu uucuguucug guuucuucgu     2100

uccgagauag cacagucuag acacuaccaa cagagguucg cggugaucuu ggaggcuuau     2160

cugcgcggcu gcgggaccgc cauguuacau gacuuuacac aacaggugca ggucauugaa     2220

augcuccaga aaguuacucu ggacaucaag ucgcuuagcg cagaaaaaua cgaugugucc     2280

ucacagguga ucagucagcu gaagcaaaaa uuggagaauc uccagaacuc ucagcugcca     2340

gagagcuucc ggguacccua ugacccugga cuaaaggccg gcgcucuggc cauugaaaag     2400

ugcaaaguca uggcauccaa gaaaaagccc cucuggcugg aguuuaaaug ugcugaucca     2460

accgcccuuu caaaugaaac aauagguauc auuuucaagc acggggacga uuugagacaa     2520

gacaugcuga ucuuacagau ucucaggauc auggagagca uaugggaaac cgagucucug     2580

gaucuuugcc ugcuaccuua cggcuguauc uccacuggag acaagauugg caugaucgag     2640

auugugaaag augcgacgac aaucgccaag auacagcaga guaccguugg gaacacugga     2700

gcuuucaaag acgaagugcu caaucauugg cugaaggaga aaagccccac cgaagagaag     2760

uuucaagcag ccgucgagcg auucguguac ucuugcgcug guuauugugu ugccacauuu     2820

guguugggca uuggggaucg ccacaacgac aauaucauga uuaccgaaac uggaaaccug     2880

uuccacaucg auuuuggcca uauauuaggu aauuacaagu ccuuccucgg gaucaacaaa     2940

gagcggguac cauuuguccu gacaccggac uuccuuuuug ugaugggcac gucaggaaag     3000

aaaaccaguc cucacuucca gaaguuucag gacauuugcg ugaaagcaua ucuggcguug     3060

agacaucaca cuaaucuccu gaucauucua uucagcauga ugcugaugac aggcaugccc     3120

cagcuuaccu cgaaggaaga uaucgaguac auaagggacg cccucacagu cgggaagaac     3180

gaagaggaug cuaaaaagua uuuucuggac caaauugagg uuugucguga uaaaggaugg     3240

acugugcagu ucaacugguu cuugcaucug guauuaggua ucaagcaggg cgaaaaacac     3300

uccgccuga                                                             3309


<210>  9226
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAH35683

<400>  9226
auggagcugg agaacuacaa gcagcccgug gugcugagag aggacaacug cagaagaaga       60

agaagaauga agcccagaag cgccgccgcc agccugagca gcauggagcu gauccccauc      120

gaguucgugc ugcccaccag ccagagaaag ugcaagagcc ccgagaccgc ccugcugcac      180

guggccggcc acggcaacgu ggagcagaug aaggcccagg uguggcugag agcccuggag      240

accagcgugg ccgccgacuu cuaccacaga cugggccccc accacuuccu gcugcuguac      300

cagaagaagg gccaguggua cgagaucuac gacaaguacc agguggugca gacccuggac      360

ugccugagau acuggaaggc cacccacaga agccccggcc agauccaccu ggugcagaga      420

caccccccca gcgaggagag ccaggccuuc cagagacagc ugaccgcccu gaucggcuac      480

gacgugaccg acgugagcaa cgugcacgac gacgagcugg aguucaccag aagaggccug      540

gugaccccca gaauggccga gguggccagc agagacccca agcuguacgc caugcacccc      600

ugggugacca gcaagccccu gcccgaguac cuguggaaga agaucgccaa caacugcauc      660

uucaucguga uccacagaag caccaccagc cagaccauca aggugagccc cgacgacacc      720

cccggcgcca uccugcagag cuucuucacc aagauggcca agaagaagag ccugauggac      780

auccccgaga gccagagcga gcaggacuuc gugcugagag ugugcggcag agacgaguac      840

cuggugggcg agacccccau caagaacuuc caguggguga gacacugccu gaagaacggc      900

gaggagaucc acguggugcu ggacaccccc cccgaccccg cccuggacga ggugagaaag      960

gaggaguggc cccuggugga cgacugcacc ggcgugaccg gcuaccacga gcagcugacc     1020

auccacggca aggaccacga gagcguguuc accgugagcc ugugggacug cgacagaaag     1080

uucagaguga agaucagagg caucgacauc cccgugcugc ccagaaacac cgaccugacc     1140

guguucgugg aggccaacau ccagcacggc cagcaggugc ugugccagag aagaaccagc     1200

cccaagcccu ucaccgagga ggugcugugg aacguguggc uggaguucag caucaagauc     1260

aaggaccugc ccaagggcgc ccugcugaac cugcagaucu acugcggcaa ggcccccgcc     1320

cugagcagca aggccagcgc cgagagcccc agcagcgaga gcaagggcaa ggugcagcug     1380

cuguacuacg ugaaccugcu gcugaucgac cacagauucc ugcugagaag aggcgaguac     1440

gugcugcaca uguggcagau cagcggcaag ggcgaggacc agggcagcuu caacgccgac     1500

aagcugacca gcgccaccaa ccccgacaag gagaacagca ugagcaucag cauccugcug     1560

gacaacuacu gccaccccau cgcccugccc aagcaccagc ccacccccga ccccgagggc     1620

gacagaguga gagccgagau gcccaaccag cugagaaagc agcuggaggc caucaucgcc     1680

accgaccccc ugaacccccu gaccgccgag gacaaggagc ugcuguggca cuucagauac     1740

gagagccuga agcaccccaa ggccuacccc aagcuguuca gcagcgugaa guggggccag     1800

caggagaucg uggccaagac cuaccagcug cuggccagaa gagaggugug ggaccagagc     1860

gcccuggacg ugggccugac caugcagcug cuggacugca acuucagcga cgagaacgug     1920

agagccaucg ccgugcagaa gcuggagagc cuggaggacg acgacgugcu gcacuaccug     1980

cugcagcugg ugcaggccgu gaaguucgag cccuaccacg acagcgcccu ggccagauuc     2040

cugcugaaga gaggccugag aaacaagaga aucggccacu uccuguucug guuccugaga     2100

agcgagaucg cccagagcag acacuaccag cagagauucg ccgugauccu ggaggccuac     2160

cugagaggcu gcggcaccgc caugcugcac gacuucaccc agcaggugca ggugaucgag     2220

augcugcaga aggugacccu ggacaucaag agccugagcg ccgagaagua cgacgugagc     2280

agccagguga ucagccagcu gaagcagaag cuggagaacc ugcagaacag ccagcugccc     2340

gagagcuuca gagugcccua cgaccccggc cugaaggccg gcgcccuggc caucgagaag     2400

ugcaagguga uggccagcaa gaagaagccc cuguggcugg aguucaagug cgccgacccc     2460

accgcccuga gcaacgagac caucggcauc aucuucaagc acggcgacga ccugagacag     2520

gacaugcuga uccugcagau ccugagaauc auggagagca ucugggagac cgagagccug     2580

gaccugugcc ugcugcccua cggcugcauc agcaccggcg acaagaucgg caugaucgag     2640

aucgugaagg acgccaccac caucgccaag auccagcaga gcaccguggg caacaccggc     2700

gccuucaagg acgaggugcu gaaccacugg cugaaggaga agagccccac cgaggagaag     2760

uuccaggccg ccguggagag auucguguac agcugcgccg gcuacugcgu ggccaccuuc     2820

gugcugggca ucggcgacag acacaacgac aacaucauga ucaccgagac cggcaaccug     2880

uuccacaucg acuucggcca cauccugggc aacuacaaga gcuuccuggg caucaacaag     2940

gagagagugc ccuucgugcu gacccccgac uuccuguucg ugaugggcac cagcggcaag     3000

aagaccagcc cccacuucca gaaguuccag gacaucugcg ugaaggccua ccuggcccug     3060

agacaccaca ccaaccugcu gaucauccug uucagcauga ugcugaugac cggcaugccc     3120

cagcugacca gcaaggagga caucgaguac aucagagacg cccugaccgu gggcaagaac     3180

gaggaggacg ccaagaagua cuuccuggac cagaucgagg ugugcagaga caagggcugg     3240

accgugcagu ucaacugguu ccugcaccug gugcugggca ucaagcaggg cgagaagcac     3300

agcgccuga                                                             3309


<210>  9227
<211>  3309
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAH35683

<400>  9227
auggagcugg aaaacuacaa gcagcccgug guccucagag aggacaauug ccggcgcaga       60

cggcgcauga aaccuagaag cgccgcugcc ucccugucua gcauggaacu uaucccgauu      120

gaguucguuc ugcccaccuc ccaacggaag uguaaaucuc cugaaacagc gcuccugcac      180

guggcuggcc augggaacgu ggagcagaug aaggcccagg ucuggcuucg cgcccuggag      240

acgagcgugg cugccgauuu uuaucacaga cucggacccc aucacuuccu gcugcucuac      300

cagaaaaagg gccaauggua ugaaaucuac gacaaguauc agguugugca gacccuggau      360

ugccuucggu acuggaaagc uacacaucgc uccccugggc agauucaccu gguccaaaga      420

caucccccuu cugaggaaag ccaggccuuu cagcggcagc ucaccgcgcu gaucggauau      480

gacgugacag auguuuccaa ugugcacgac gaugagcuug aguucacccg cagaggccug      540

gucacaccgc ggauggccga aguggcuagc cgcgacccca agcucuacgc caugcacccu      600

ugggugaccu cuaaaccccu gccugaguac cuguggaaga aaauugcuaa caauuguauc      660

uuuaucguca uucauagauc cacgaccagc caaacaauca agguuucucc cgaugacacc      720

ccgggggcca uucuccaguc cuucuuuaca aagauggcga aaaagaaaag ccugauggau      780

aucccugaau cucaguccga gcaagacuuc gugcuucggg ugugcggaag agaugaauau      840

cuggucggcg agacccccau uaagaacuuu cagugggugc gccacugucu caaaaauggc      900

gaggaaaucc acguugugcu ggacacgccu cccgaccccg cccuugauga gguccggaag      960

gaagaguggc cucuggugga cgauugcaca gggguuaccg gauaccauga acagcucaca     1020

auucacggca aagaccauga gagcguguuc accgucuccc ugugggauug ugacagaaag     1080

uuucgcguga agauccgggg gaucgauauu ccgguccugc ccagaaacac cgaccucaca     1140

guguucguug aggcuaauau ccagcacgga caacaggugc ugugccagcg ccggacgucu     1200

ccuaaacccu uuaccgaaga gguccuuugg aacguguggc uggaguucag cauuaagauc     1260

aaagaucucc cuaagggcgc ccugcuuaau cugcagauuu auugugggaa agcucccgcc     1320

cucuccagca aggccucugc ugaauccccg agcucugaaa gcaagggaaa aguucaacug     1380

cuguacuaug ugaaccuccu gcuuaucgac cauagauucc ugcuccgccg gggcgaguac     1440

guccugcaca uguggcagau cuccggcaag ggggaggauc agggaucuuu uaaugcggac     1500

aaacugacaa gcgccaccaa cccugacaag gaaaauucca ugagcauuuc uauccuucuc     1560

gauaacuauu gccaccccau ugcucugccu aaacaucagc ccacaccuga ccccgagggc     1620

gauagagugc gcgccgaaau gccgaaccaa cugcggaagc agcucgaggc caucauugcu     1680

accgacccuc ugaauccccu uacggccgag gauaaggaac ugcucuggca cuucagauac     1740

gagucccuga aacaucccaa ggcguacccu aaacuguuua gcucugugaa gugggggcag     1800

caggaaaucg uugcuaaaac auaucaacuu cucgcccggc gcgaggucug ggaccagucc     1860

gcccuggaug ugggacugac caugcagcuc cuggacugua acuucagcga ugaaaaugug     1920

agagcuaucg ccguccaaaa acuugagucc cuggaggacg augacgugcu ccacuaccug     1980

cugcagcuug uucaggcugu gaaguuugaa ccguaucacg auucugcccu cgcgcgguuc     2040

cugcugaaaa gaggccuccg caacaagcgg auugggcauu uucuguucug guuucuuaga     2100

agcgagaucg cccagucccg ccacuaccaa cagagauucg cugucauucu ggaagccuau     2160

cuccggggau gcggcaccgc uaugcugcau gacuuuacac aacaggugca gguuaucgag     2220

augcugcaga aagugacccu ugacauuaag ucucucagcg ccgaaaaaua cgaugucucc     2280

agccagguga ucucucagcu gaagcaaaaa cuggagaauc uccagaacuc ccagcugccc     2340

gagagcuucc gcguuccuua ugaccccggc cuuaaggcgg gggcccuggc uauugaaaag     2400

ugcaaaguga uggccucuaa gaaaaagccu cucuggcugg aguuuaaaug ugcugauccc     2460

acagcccugu ccaaugaaac gaucggaauc auuuucaagc acggcgacga ucuuagacaa     2520

gacaugcuga uccuccagau ucugcggauc auggagagca uuugggaaac cgagucucuc     2580

gaucugugcc uucugccuua cggguguauc agcacaggag acaagaucgg caugauugag     2640

aucgucaaag augccaccac aauugcuaag auccagcagu ccaccguggg gaacacgggc     2700

gcguucaaag acgaagugcu caaucauugg cugaaggaga aaagccccac cgaagagaag     2760

uuucaagccg cugucgagcg cuucguuuac ucuugcgccg gauauugugu ggccacauuu     2820

gugcugggca uuggggauag acacaacgac aauaucauga ucaccgaaac aggaaaccuu     2880

uuccacauug auuuuggcca uauccugggg aauuacaagu ccuuccucgg aauuaacaaa     2940

gagcgggucc cguuugugcu gaccccugac uuccucuuug uuaugggcac gagcgggaag     3000

aaaacaucuc cccacuucca gaaguuucag gacaucugcg ugaaggcuua ucuggcccuu     3060

cgccaucaca ccaaucugcu cauuauccug uucuccauga ugcugaugac aggcaugccu     3120

cagcuuacca gcaaggaaga uaucgaguac auuagagacg cgcugaccgu cggaaagaac     3180

gaagaggaug cuaaaaagua uuuucucgac caaaucgagg ugugucggga uaaaggcugg     3240

acaguucagu ucaacugguu ccugcaucuc gugcugggga uuaagcaggg agaaaaacac     3300

uccgccuga                                                             3309


<210>  9228
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__Q5UE93

<400>  9228

Met Glu Ser Ser Asp Val Glu Leu Asp Leu Gln Arg Ser Val Gln Ala 
1               5                   10                  15      


Val Leu Arg Glu Leu Ser Thr Gln Ala Pro Ala Leu Gln Ser Asn Gln 
            20                  25                  30          


Gly Met Trp Arg Trp Ser Leu His Lys Lys Val Glu Arg Asp Pro Gly 
        35                  40                  45              


Lys Ser Pro Val Leu Val Arg Ile Leu Leu Arg Glu Leu Glu Lys Ala 
    50                  55                  60                  


Glu Ser Gln Asp Leu Arg His Val Ile Ile Pro Leu Leu His Thr Val 
65                  70                  75                  80  


Met Tyr Val Leu Thr Lys Ala Thr Gly Ile Thr Glu Glu Leu Tyr Gln 
                85                  90                  95      


Arg Ile Tyr Ala Phe Cys Thr Arg Leu Leu Thr Leu Pro Thr Pro Tyr 
            100                 105                 110         


Cys Thr Val Ala Leu Asp Cys Ala Ile Arg Leu Lys Thr Glu Met Ala 
        115                 120                 125             


Val Pro Gly Thr Leu Tyr Gln Arg Met Val Ile Ala Glu Gln Asn Leu 
    130                 135                 140                 


Thr Asn Glu Leu Tyr Pro Tyr Gln Glu Arg Val Phe Leu Phe Val Asp 
145                 150                 155                 160 


Pro Glu Leu Val Ser Ala Ser Val Cys Ser Ala Leu Leu Leu Glu Ile 
                165                 170                 175     


Glu Ala Ala Gln Ala Gln Gln Thr Pro Glu Thr Cys Met Arg His Val 
            180                 185                 190         


Val Ser His Ala Leu Gln Ala Ala Leu Gly Glu Ala Cys His Ala Gly 
        195                 200                 205             


Ala Leu His Arg Lys Leu Gln Ala Ser Pro Arg Arg Thr Leu Glu His 
    210                 215                 220                 


Tyr Phe His Ala Val Val Ala Ala Leu Glu Gln Met Ala Ser Glu Ala 
225                 230                 235                 240 


Ser Pro Ser Arg Glu Gly His Val Glu Arg Leu Glu Glu Ile Tyr Cys 
                245                 250                 255     


Ser Leu Leu Gly Pro Ala Ala Gly Arg Cys Gly Gly Asp Leu Val Gln 
            260                 265                 270         


Glu Arg Pro Pro Ser Ile Pro Leu Pro Ser Pro Tyr Ile Thr Phe His 
        275                 280                 285             


Leu Trp Thr Gly Glu Glu Gln Leu Trp Lys Glu Leu Val Leu Phe Leu 
    290                 295                 300                 


Arg Pro Arg Ser Gln Leu Arg Leu Ser Ala Asp Leu Glu Val Leu Asp 
305                 310                 315                 320 


Leu Gln Gly Leu Arg Pro Asp Arg Glu Leu Ala Arg Val Ser Val Leu 
                325                 330                 335     


Ser Thr Asp Ser Gly Ile Glu Arg Asp Leu Pro Thr Gly Ala Asp Glu 
            340                 345                 350         


Leu Pro Ala Pro Gly Ser Pro Glu Met Glu Arg Ala Gly Leu Gln Arg 
        355                 360                 365             


Lys Gly Gly Ile Lys Lys Arg Ala Trp Pro Leu Asp Phe Leu Met Pro 
    370                 375                 380                 


Gly Ser Trp Asp Gly Pro Pro Gly Leu His Arg Arg Thr Gly Arg Pro 
385                 390                 395                 400 


Ser Gly Asp Gly Glu Met Leu Pro Gly Val Ser Arg Leu His Thr Ala 
                405                 410                 415     


Arg Val Leu Val Leu Gly Asp Asp Arg Met Leu Gly Arg Leu Ala Gln 
            420                 425                 430         


Ala Tyr His Arg Leu Arg Lys Arg Glu Thr Gln Lys Phe Cys Leu Thr 
        435                 440                 445             


Pro Arg Leu Ser Leu Gln Leu Tyr Tyr Ile Pro Val Leu Ala Pro Glu 
    450                 455                 460                 


Lys Pro Ala Ala Ser Arg Gln Pro Glu Leu Gly Glu Leu Ala Thr Phe 
465                 470                 475                 480 


Leu Gly Arg Val Asp Pro Trp Tyr Gln Ser Asn Val Asn Thr Leu Cys 
                485                 490                 495     


Pro Ala Ile His Lys Leu Ala Glu Met Pro Pro Ser Leu Asp Thr Ser 
            500                 505                 510         


Arg Thr Val Asp Pro Phe Ile Leu Asp Val Ile Thr Tyr Tyr Ile Arg 
        515                 520                 525             


Met Gly Thr Gln Pro Ile Tyr Phe Gln Ile Tyr Thr Val Lys Ile Phe 
    530                 535                 540                 


Phe Ser Asp Leu Ser Gln Asp Pro Thr Glu Asp Ile Phe Leu Ile Glu 
545                 550                 555                 560 


Leu Lys Val Lys Ile Gln Asp Ser Lys Phe Pro Lys Asp Gly Phe Ser 
                565                 570                 575     


Pro Arg Arg Arg Gly Val Ala Glu Gly Pro Gly Ala Glu Leu Ser Leu 
            580                 585                 590         


Cys Tyr Gln Lys Ala Leu Leu Ser His Arg Pro Arg Glu Val Thr Val 
        595                 600                 605             


Ser Leu Arg Ala Thr Gly Leu Ile Leu Lys Ala Ile Pro Ala Ser Asp 
    610                 615                 620                 


Thr Glu Val Ser Gly Ser Ser His Cys Pro Leu Pro Ala Ala Pro Val 
625                 630                 635                 640 


Thr Asp His Thr Cys Leu Asn Val Asn Val Thr Glu Val Val Lys Ser 
                645                 650                 655     


Ser Asn Leu Ala Gly Lys Ser Phe Ser Thr Val Thr Asn Thr Phe Arg 
            660                 665                 670         


Thr Asn Asn Ile Gln Ile Gln Ser Arg Asp Gln Arg Leu Leu Thr Leu 
        675                 680                 685             


Ser Leu Asp Lys Asp Asp Gln Arg Thr Phe Arg Asp Val Val Arg Phe 
    690                 695                 700                 


Glu Val Ala Pro Cys Pro Glu Pro Cys Ser Gly Ala Gln Lys Ser Lys 
705                 710                 715                 720 


Ala Pro Trp Leu Asn Leu His Gly Gln Gln Glu Val Glu Ala Ile Lys 
                725                 730                 735     


Ala Lys Pro Lys Pro Leu Leu Met Pro Ile Asn Thr Phe Ser Gly Ile 
            740                 745                 750         


Val Gln 
        


<210>  9229
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAV30085

<400>  9229
auggagagcu cagaugugga gcuggaccuc cagaggagcg ugcaggcugu gcuccgggag       60

cucagcaccc aggccccugc ccugcagagc aaccaaggca uguggaggug gucccugcac      120

aagaaggucg agcgagaucc cgguaagagc ccagugcugg uccgcauucu ucucagagaa      180

cuggagaagg cggaaagcca ggaccuccgg caugucauca uucccuugcu gcacacugua      240

auguacgugc ucaccaaggc cacaggaauc acagaagagc ucuaccagag aaucuaugcc      300

uuuugcacaa gguuacugac ccugcccacc cccuacugca cagucgccuu ggacugcgcg      360

auaaggcuga aaacggagau ggcuguccca gggacacugu accaaaggau ggucauugcc      420

gaacagaacu ugacgaauga gcuguauccc uaccaggaga gaguguuccu cuucguggau      480

ccugagcugg ugucugcguc ugugugcagu gcucugcuac uggagaucga ggcggcccag      540

gcgcagcaga caccagagac cugcaugcgc cacguggucu cccacgcccu gcaggcggcu      600

cugggggagg ccugucacgc aggcgcucug cacaggaagc ugcaggccag cccucgccgc      660

acccuggagc acuauuucca cgccguggug gccgccuugg agcagauggc cagcgaggcc      720

agcccgagcc gggagggaca cguagagagg cuggaggaga uuuacugcuc gcugcugggu      780

cccgcggcgg ggcgcugcgg uggugaccuu guccaagagc ggccaccaag cauuccccug      840

cccagccccu acaucaccuu ccacuugugg accggugagg agcagcucug gaaggaacug      900

gugcucuucc uccgcccaag aucccagcug cgccucagug cugacuugga ggucuuggau      960

cugcagggcc uccggccgga ccgggaguug gcccggguuu cugugcuguc cacugacagc     1020

ggcauugagc gggaccuucc cacgggggcu gaugagcugc cugcacccgg cagcccugag     1080

auggagcgag ccgggcugca gcgcaaaggg ggcaucaaga agcgugcaug gccccuggac     1140

uucuugaugc cuggcagcug ggacgggccc ccagggcugc accggaggac aggccggccc     1200

aguggggaug gggaaaugcu gcccggcgug ucccggcugc acacagcccg gguacuugug     1260

cucggagaug acaggaugcu ggggcgccug gcccaggccu accacagacu caggaaacgg     1320

gagacccaga aguucugccu cacucccaga cucagccugc agcucuacua cauccccgug     1380

cuggcgccug agaagccugc agcauccagg cagccggagc ugggagagcu ggcuacguuc     1440

cugggccgcg uagacccgug guaccagagc aacgucaaca cgcugugccc cgccauccac     1500

aagcuggcug agaugccucc uucccuggac acaucccgga cuguggaccc cuucauccua     1560

gacgucauca ccuacuacau ccgcaugggc acccaaccca ucuauuucca gaucuacaca     1620

gucaagaucu uuuucaguga ccugagccaa gacccuacug aggacauuuu ccucauugaa     1680

cugaagguga agauccaaga uucuaaauuc cccaaagaug gcuuuucacc caggaggaga     1740

ggcguggcug agggcccagg ggcagagcuc ucccuaugcu accagaaggc cuugcuuagc     1800

caccggcccc gagaggucac cguuucccug cgggccacug ggcugauccu gaaggccauu     1860

ccagccagcg acacagaagu uucagggucu agccauugcc cccugccugc ugcuccuguc     1920

acagaccaca caugucugaa ugucaacgug acagagguug ucaaguccuc caacuuggcg     1980

ggaaaguccu ucucuacagu gaccaacacc uucaggacga acaauaucca gauccagagc     2040

cgggaccaga ggcugcugac acugucgcug gacaaggacg aucaacgcac uuucagggau     2100

guggucagau ucgagguugc ucccugccca gaaccauguu cuggggccca gaaguccaag     2160

gcaccguggc ucaauuugca ugggcaacag gagguggaag caaucaaagc caagcccaag     2220

ccccuucuga ugcccaucaa cacauucucu gguauugucc aguga                     2265


<210>  9230
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAV30085

<400>  9230
auggagagcu ccgacgugga gcuggaccuc cagcgcagcg uccaggccgu gcugcgggag       60

cuguccaccc aggcccccgc gcuccagagc aaccagggca uguggcgcug gucccugcac      120

aagaaggugg agcgggaccc ggggaagucc cccguccugg ugcgcauccu ccugcgggag      180

cuggagaagg ccgaguccca ggaccuccgc cacgugauca ucccccugcu gcacaccguc      240

auguacgugc ucacgaaggc caccggcauc accgaggagc uguaccagcg gaucuacgcc      300

uucugcaccc gccugcucac gcugcccacc ccguacugca ccguggcccu ggacugcgcg      360

auccggcuca agaccgagau ggccgucccc gggacgcugu accagcgcau ggugaucgcc      420

gagcagaacc ugaccaacga gcucuacccc uaccaggagc ggguguuccu guucgucgac      480

cccgagcugg ugagcgccuc cgugugcagc gcgcuccugc uggagaucga ggccgcccag      540

gcccagcaga ccccggagac cugcaugcgc cacgucgugu cccacgcccu ccaggcggcc      600

cugggcgagg ccugccacgc cggggcccug caccggaagc uccaggcgag cccccgccgg      660

acgcuggagc acuacuucca cgccgugguc gccgcccugg agcagauggc cuccgaggcg      720

agccccuccc gcgagggcca cguggagcgg cucgaggaga ucuacugcag ccugcugggc      780

cccgccgccg ggcgcugcgg cggggaccuc gugcaggagc ggccgcccuc caucccccug      840

cccagcccgu acaucaccuu ccaccugugg accggcgagg agcagcucug gaaggagcug      900

guccuguucc uccgcccccg gucccagcug cgccugagcg ccgaccucga ggugcuggac      960

cugcaggggc uccgccccga ccgggagcug gcccgcguga gcguccuguc caccgacagc     1020

ggcaucgagc gggaccugcc cacgggcgcg gacgagcucc cggcccccgg gucccccgag     1080

auggagcgcg ccggccugca gcggaagggc gggaucaaga agcgcgccug gccccuggac     1140

uuccucaugc cgggcagcug ggacgggccg cccggccugc accggcgcac cgggcggccc     1200

uccggcgacg gggagaugcu gcccggcgug agccgccucc acaccgcgcg gguccuggug     1260

cugggcgacg accgcaugcu cgggcggcug gcccaggccu accaccgccu gcggaagcgc     1320

gagacccaga aguucugccu cacgccccgg cugucccugc agcucuacua cauccccgug     1380

cuggccccgg agaagcccgc cgcgagccgc cagcccgagc ugggcgagcu cgccaccuuc     1440

cuggggcggg ucgaccccug guaccagucc aacgugaaca cccugugccc ggccauccac     1500

aagcucgccg agaugccgcc cagccuggac accucccgca cgguggaccc cuucauccug     1560

gacgucauca ccuacuacau ccgcaugggc acccagccca ucuacuucca gaucuacacc     1620

gugaagaucu ucuucagcga ccucucccag gaccccacgg aggacaucuu ccugaucgag     1680

cugaagguga agauccagga cagcaaguuc cccaaggacg gguucagccc ccggcgccgg     1740

ggcgucgccg agggcccggg ggcggagcuc agccugugcu accagaaggc ccugcucucc     1800

caccgccccc gggaggugac cgugagccug cgcgccaccg gccugauccu caaggccauc     1860

cccgccuccg acaccgaggu cagcgggagc ucccacugcc cccugccggc ggcccccgug     1920

acggaccaca cgugccugaa cgugaacguc accgaggugg ucaagagcuc caaccucgcc     1980

ggcaagagcu ucuccaccgu gaccaacacc uuccggacca acaacaucca gauccagagc     2040

cgcgaccagc ggcugcugac ccucucccug gacaaggacg accagcgcac cuuccgggac     2100

guggugcgcu ucgaggucgc ccccugcccc gagccgugca gcggggcgca gaaguccaag     2160

gcccccuggc ugaaccucca cggccagcag gagguggagg ccaucaaggc caagcccaag     2220

ccccugcuga ugccgaucaa cacguucagc ggcaucgugc aguga                     2265


<210>  9231
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAV30085

<400>  9231
auggaguccu ccgacgucga gcucgaccuc cagcgcuccg uccaggccgu ccuccgcgag       60

cucuccaccc aggcccccgc ccuccagucc aaccagggca uguggcgcug gucccuccac      120

aagaaggucg agcgcgaccc cggcaagucc cccguccucg uccgcauccu ccuccgcgag      180

cucgagaagg ccgaguccca ggaccuccgc cacgucauca ucccccuccu ccacaccguc      240

auguacgucc ucaccaaggc caccggcauc accgaggagc ucuaccagcg caucuacgcc      300

uucugcaccc gccuccucac ccuccccacc cccuacugca ccgucgcccu cgacugcgcc      360

auccgccuca agaccgagau ggccgucccc ggcacccucu accagcgcau ggucaucgcc      420

gagcagaacc ucaccaacga gcucuacccc uaccaggagc gcgucuuccu cuucgucgac      480

cccgagcucg ucuccgccuc cgucugcucc gcccuccucc ucgagaucga ggccgcccag      540

gcccagcaga cccccgagac cugcaugcgc cacgucgucu cccacgcccu ccaggccgcc      600

cucggcgagg ccugccacgc cggcgcccuc caccgcaagc uccaggccuc cccccgccgc      660

acccucgagc acuacuucca cgccgucguc gccgcccucg agcagauggc cuccgaggcc      720

ucccccuccc gcgagggcca cgucgagcgc cucgaggaga ucuacugcuc ccuccucggc      780

cccgccgccg gccgcugcgg cggcgaccuc guccaggagc gcccccccuc caucccccuc      840

cccucccccu acaucaccuu ccaccucugg accggcgagg agcagcucug gaaggagcuc      900

guccucuucc uccgcccccg cucccagcuc cgccucuccg ccgaccucga gguccucgac      960

cuccagggcc uccgccccga ccgcgagcuc gcccgcgucu ccguccucuc caccgacucc     1020

ggcaucgagc gcgaccuccc caccggcgcc gacgagcucc ccgcccccgg cucccccgag     1080

auggagcgcg ccggccucca gcgcaagggc ggcaucaaga agcgcgccug gccccucgac     1140

uuccucaugc ccggcuccug ggacggcccc cccggccucc accgccgcac cggccgcccc     1200

uccggcgacg gcgagaugcu ccccggcguc ucccgccucc acaccgcccg cguccucguc     1260

cucggcgacg accgcaugcu cggccgccuc gcccaggccu accaccgccu ccgcaagcgc     1320

gagacccaga aguucugccu caccccccgc cucucccucc agcucuacua cauccccguc     1380

cucgcccccg agaagcccgc cgccucccgc cagcccgagc ucggcgagcu cgccaccuuc     1440

cucggccgcg ucgaccccug guaccagucc aacgucaaca cccucugccc cgccauccac     1500

aagcucgccg agaugccccc cucccucgac accucccgca ccgucgaccc cuucauccuc     1560

gacgucauca ccuacuacau ccgcaugggc acccagccca ucuacuucca gaucuacacc     1620

gucaagaucu ucuucuccga ccucucccag gaccccaccg aggacaucuu ccucaucgag     1680

cucaagguca agauccagga cuccaaguuc cccaaggacg gcuucucccc ccgccgccgc     1740

ggcgucgccg agggccccgg cgccgagcuc ucccucugcu accagaaggc ccuccucucc     1800

caccgccccc gcgaggucac cgucucccuc cgcgccaccg gccucauccu caaggccauc     1860

cccgccuccg acaccgaggu cuccggcucc ucccacugcc cccuccccgc cgcccccguc     1920

accgaccaca ccugccucaa cgucaacguc accgaggucg ucaaguccuc caaccucgcc     1980

ggcaaguccu ucuccaccgu caccaacacc uuccgcacca acaacaucca gauccagucc     2040

cgcgaccagc gccuccucac ccucucccuc gacaaggacg accagcgcac cuuccgcgac     2100

gucguccgcu ucgaggucgc ccccugcccc gagcccugcu ccggcgccca gaaguccaag     2160

gcccccuggc ucaaccucca cggccagcag gaggucgagg ccaucaaggc caagcccaag     2220

ccccuccuca ugcccaucaa caccuucucc ggcaucgucc aguga                     2265


<210>  9232
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAV30085

<400>  9232
auggagagcu ccgacgugga acuggaucuc cagagaucug uccaagccgu ucuuagggag       60

cugucaaccc aggcucccgc auugcagagu aaccagggca uguggcggug gagcuuacac      120

aagaaagugg aacgcgaccc ugggaagucc ccaguacugg ugcgaauccu acuccgugag      180

cuggaaaaag ccgagucuca agaucuuaga caugucauua uaccgcuguu gcacacagug      240

auguacguuc ucacuaaggc gacgggaauc accgaggaac uguaucagag gauuuacgcu      300

uucugcacac ggcugcucac uuuacccacc ccuuauugua caguggcccu ggacugcgca      360

auccgccuua aaaccgagau ggccguccca gguacuuugu accagagaau ggugauugcu      420

gaacagaauc ugacaaacga gcuauauccc uaccaagaga ggguauuucu cuucguugau      480

ccugaacugg ugucggcauc agucuguagc gcccuucugu uggagaucga agcugcccag      540

gcgcagcaga ccccagagac gugcaugcgg caugugguga gucacgcacu ccaagccgcu      600

cugggcgaag ccugucaugc aggggcuuua caccgcaagc ugcaggccuc uccccgaaga      660

acucucgagc acuauuuuca ugcggucguu gccgcacuug agcagauggc uuccgaagcc      720

agcccuucca gggagggaca cguggaacgg cuggaggaaa uauacugcuc auugcuaggc      780

ccagcugccg gucguugugg gggagaccug guacaagagc gcccgcccag uaucccucuc      840

ccaagccccu acauuaccuu ccaucugugg acaggcgagg aacagcuuug gaaggagcug      900

guguuguuuc ucagaccuag gucucagcug cgguuauccg cagaucugga aguccuagac      960

cuccagggcc ugcgaccaga ucgcgagcuu gccagagugu caguuuugag cacugacagu     1020

gggaucgaaa gggaucugcc caccggagcu gacgagcucc cggcgccugg uucucccgag     1080

auggaacggg caggccugca acgcaaaggg ggaauuaaga aaagagccug gccacuugau     1140

uuccugaugc cuggcuccug ggacgguccc ccaggguugc acaggcguac aggacggccc     1200

agcggcgacg gcgagaugcu cccuggggug ucgcgacugc acaccgcuag agucuuagug     1260

cugggagaug acaggaugcu aggucgccuc gcccaggcau aucaucggcu gagaaagagg     1320

gaaacgcaga aauuuugccu uacuccacgc uugucucugc agcucuacua uaucccggua     1380

cuggcccccg agaagccugc ugccucccga caaccagagu uaggcgaacu ggcaacauuc     1440

cuugggcggg uugaucccug guaccaguca aaugugaaca ccuugugucc ugcgauacac     1500

aagcucgcug agaugccacc cagucuggac acuagccgua cagucgaucc guuuauucua     1560

gacgugauca ccuauuacau uagaauggga acgcagccua ucuauuucca gaucuacacc     1620

gucaaaauau uuuucuccga ucugucucaa gacccaacag aagauauuuu ucucaucgag     1680

cugaagguga aaauucagga cagcaaguuc cccaaagaug gcuucucacc uaggcgccgg     1740

gguguugccg aagggcccgg cgcagagcuu aguuugugcu accagaaggc ccuguuaucc     1800

cauagaccaa gggaggugac uguaagccuc cgagcuaccg gacugauccu uaaagccaua     1860

ccugcaucug acacagaagu cucaggcagu agccacuguc cccugccagc ugccccggug     1920

acugaccaua ccugcuugaa uguuaacgug acagaggucg ugaaguccuc uaaucucgcg     1980

gggaagucgu uuagcaccgu aacuaacacg uuccgcacaa auaacauuca gauccaaucc     2040

cgggaucaga gacugcuaac ccugucacuc gacaaagaug accagaggac uuuucgugau     2100

gugguucgcu ucgaagucgc cccuugcccc gagccaugua guggagcuca aaagucuaaa     2160

gcacccuggc ugaaucuuca cggucagcag gaaguggagg ccaucaaggc uaaaccuaag     2220

ccauugcuga ugcccauuaa caccuuuagc ggcaucgugc aguga                     2265


<210>  9233
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAV30085

<400>  9233
auggagagca gcgacgugga gcuggaccug cagagaagcg ugcaggccgu gcugagagag       60

cugagcaccc aggcccccgc ccugcagagc aaccagggca uguggagaug gagccugcac      120

aagaaggugg agagagaccc cggcaagagc cccgugcugg ugagaauccu gcugagagag      180

cuggagaagg ccgagagcca ggaccugaga cacgugauca ucccccugcu gcacaccgug      240

auguacgugc ugaccaaggc caccggcauc accgaggagc uguaccagag aaucuacgcc      300

uucugcacca gacugcugac ccugcccacc cccuacugca ccguggcccu ggacugcgcc      360

aucagacuga agaccgagau ggccgugccc ggcacccugu accagagaau ggugaucgcc      420

gagcagaacc ugaccaacga gcuguacccc uaccaggaga gaguguuccu guucguggac      480

cccgagcugg ugagcgccag cgugugcagc gcccugcugc uggagaucga ggccgcccag      540

gcccagcaga cccccgagac cugcaugaga cacgugguga gccacgcccu gcaggccgcc      600

cugggcgagg ccugccacgc cggcgcccug cacagaaagc ugcaggccag ccccagaaga      660

acccuggagc acuacuucca cgccguggug gccgcccugg agcagauggc cagcgaggcc      720

agccccagca gagagggcca cguggagaga cuggaggaga ucuacugcag ccugcugggc      780

cccgccgccg gcagaugcgg cggcgaccug gugcaggaga gaccccccag caucccccug      840

cccagccccu acaucaccuu ccaccugugg accggcgagg agcagcugug gaaggagcug      900

gugcuguucc ugagacccag aagccagcug agacugagcg ccgaccugga ggugcuggac      960

cugcagggcc ugagacccga cagagagcug gccagaguga gcgugcugag caccgacagc     1020

ggcaucgaga gagaccugcc caccggcgcc gacgagcugc ccgcccccgg cagccccgag     1080

auggagagag ccggccugca gagaaagggc ggcaucaaga agagagccug gccccuggac     1140

uuccugaugc ccggcagcug ggacggcccc cccggccugc acagaagaac cggcagaccc     1200

agcggcgacg gcgagaugcu gcccggcgug agcagacugc acaccgccag agugcuggug     1260

cugggcgacg acagaaugcu gggcagacug gcccaggccu accacagacu gagaaagaga     1320

gagacccaga aguucugccu gacccccaga cugagccugc agcuguacua cauccccgug     1380

cuggcccccg agaagcccgc cgccagcaga cagcccgagc ugggcgagcu ggccaccuuc     1440

cugggcagag uggaccccug guaccagagc aacgugaaca cccugugccc cgccauccac     1500

aagcuggccg agaugccccc cagccuggac accagcagaa ccguggaccc cuucauccug     1560

gacgugauca ccuacuacau cagaaugggc acccagccca ucuacuucca gaucuacacc     1620

gugaagaucu ucuucagcga ccugagccag gaccccaccg aggacaucuu ccugaucgag     1680

cugaagguga agauccagga cagcaaguuc cccaaggacg gcuucagccc cagaagaaga     1740

ggcguggccg agggccccgg cgccgagcug agccugugcu accagaaggc ccugcugagc     1800

cacagaccca gagaggugac cgugagccug agagccaccg gccugauccu gaaggccauc     1860

cccgccagcg acaccgaggu gagcggcagc agccacugcc cccugcccgc cgcccccgug     1920

accgaccaca ccugccugaa cgugaacgug accgaggugg ugaagagcag caaccuggcc     1980

ggcaagagcu ucagcaccgu gaccaacacc uucagaacca acaacaucca gauccagagc     2040

agagaccaga gacugcugac ccugagccug gacaaggacg accagagaac cuucagagac     2100

guggugagau ucgagguggc ccccugcccc gagcccugca gcggcgccca gaagagcaag     2160

gcccccuggc ugaaccugca cggccagcag gagguggagg ccaucaaggc caagcccaag     2220

ccccugcuga ugcccaucaa caccuucagc ggcaucgugc aguga                     2265


<210>  9234
<211>  2265
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAV30085

<400>  9234
auggagagcu ccgacgugga acuggaucuc cagagaucug uccaagccgu ucugcgggag       60

cuuagcaccc aggcucccgc ccugcagucc aaccagggca uguggcgcug gucucuccac      120

aagaaagugg aaagagaccc uggaaagagc ccggugcugg uccggauccu ucugcgcgag      180

cucgaaaaag cggaguccca agaucugaga caugugauua ucccccugcu ccacacaguu      240

auguacgugc ugacgaaggc uaccgggauu acagaggaac uuuaucagcg gaucuacgcc      300

uucugcaccc gccugcucac acugccuacc cccuauugua cagucgcccu ugacugcgcu      360

auuagacuga aaaccgagau ggccgugccu ggcacgcucu accagcggau gguuaucgcu      420

gaacagaauc ugaccaacga gcuguauccc uaccaagagc gcguguuucu cuucgucgau      480

ccugaacugg ugucugccag cguguguucc gcgcuucugc ucgagaucga agccgcucag      540

gcccagcaga caccggagac cugcaugaga caugucguua gccacgcucu gcaagccgcg      600

cuuggggaag ccugucaugc uggagcccug caccggaagc uccaggcuuc uccccgcaga      660

acacuggagc acuauuuuca ugccguggug gccgcucugg agcagauggc guccgaagcc      720

agcccuucuc gggagggcca cgucgaacgc cucgaggaaa uuuacugcuc ccugcuuggg      780

cccgcugccg gaagaugugg cggcgaccug gugcaagagc ggccucccag caucccgcuc      840

ccuucucccu acauuaccuu ccaucugugg acgggggagg aacagcuuug gaaggagcug      900

guucucuuuc ugagaccucg cucccagcug cggcucagcg ccgaucugga agugcuugac      960

cugcagggac ucagacccga ucgcgagcug gcucgggucu ccgugcuguc uacagacagc     1020

ggcaucgaaa gagaucuucc caccggggcc gacgagcucc cugcgccggg aucccccgag     1080

auggaacgcg cuggccugca acggaaaggg ggaauuaaga aaagagccug gccucuggau     1140

uuccucaugc ccggcagcug ggacggcccu cccgggcugc accgccggac aggaagaccg     1200

ucuggcgacg gggagaugcu uccuggaguu ucccgccugc acaccgcccg ggugcucguc     1260

cugggcgaug acagaaugcu ggggcggcuu gcucaggccu aucaucgccu cagaaagcgg     1320

gaaacccaga aauuuugccu gacacccaga cugagccucc agcuguacua uaucccugug     1380

cuugcucccg agaagccugc cgcgucucgc caacccgagc ugggagaacu cgccacguuc     1440

cugggccggg ucgauccgug guaccagagc aaugugaaca cccugugucc ugcuauucac     1500

aaacuugccg agaugccucc cucccucgac acaucuagaa ccguugaucc cuuuauccug     1560

gacgugauca cauauuacau ucgcaugggc acccagccga ucuauuucca gauuuacacg     1620

gucaagaucu uuuucagcga ucugucccaa gaccccacag aagauauuuu ucucaucgag     1680

cugaagguga aaauccagga cagcaaguuc ccuaaagaug gguucucucc cagacggcgc     1740

ggaguugcug aaggcccugg ggccgagcuu ucccugugcu accagaaggc gcuccugagc     1800

cauagacccc gggaggugac cgucucucug cgcgccaccg gacuuauucu caaagcuauc     1860

ccugccuccg acacagaagu gagcggcucc ucucacuguc cccugccggc ugccccugug     1920

accgaccaua caugccugaa uguuaacguc acggaggugg ucaagagcuc caaucucgcc     1980

gggaagucuu uuagcaccgu gacaaacacc uucagaacaa auaacauuca gauccaaucc     2040

cgggaucagc gccugcuuac ccugagccuc gacaaagaug accagagaac guuucgggau     2100

gugguucgcu ucgaaguggc ucccugcccu gagcccuguu cuggcgcgca aaaguccaaa     2160

gccccguggc ugaaucugca cggacagcag gaagucgagg cuauuaaggc caaaccuaag     2220

ccccuucuga ugccuaucaa caccuuuagc ggcaucgugc aguga                     2265


<210>  9235
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__Q8NEB9

<400>  9235

Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp 
1               5                   10                  15      


Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln 
            20                  25                  30          


Lys Ser Tyr Lys Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly 
        35                  40                  45              


Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe 
    50                  55                  60                  


Ala Glu Gly Lys Pro Leu Ala Leu Pro Val Arg Thr Ser Tyr Lys Ala 
65                  70                  75                  80  


Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys 
                85                  90                  95      


Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp 
            100                 105                 110         


Val Tyr Gly Pro Gly Lys Ala Val Pro Val Gly Gly Thr Thr Val Ser 
        115                 120                 125             


Leu Phe Gly Lys Tyr Gly Met Phe Arg Gln Gly Met His Asp Leu Lys 
    130                 135                 140                 


Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Lys Thr Pro 
145                 150                 155                 160 


Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala 
                165                 170                 175     


Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp 
            180                 185                 190         


Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Glu 
        195                 200                 205             


Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Val Glu Phe Arg Cys Val 
    210                 215                 220                 


Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly 
225                 230                 235                 240 


Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro 
                245                 250                 255     


Asp Pro Gln Met Ser Met Glu Asn Leu Val Glu Ser Lys His His Lys 
            260                 265                 270         


Leu Ala Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro 
        275                 280                 285             


Asn Ala Ala Thr Arg Asp Gln Leu Asn Ile Ile Val Ser Tyr Pro Pro 
    290                 295                 300                 


Thr Lys Gln Leu Thr Tyr Glu Glu Gln Asp Leu Val Trp Lys Phe Arg 
305                 310                 315                 320 


Tyr Tyr Leu Thr Asn Gln Glu Lys Ala Leu Thr Lys Phe Leu Lys Cys 
                325                 330                 335     


Val Asn Trp Asp Leu Pro Gln Glu Ala Lys Gln Ala Leu Glu Leu Leu 
            340                 345                 350         


Gly Lys Trp Lys Pro Met Asp Val Glu Asp Ser Leu Glu Leu Leu Ser 
        355                 360                 365             


Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu 
    370                 375                 380                 


Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Leu Gln Leu Val 
385                 390                 395                 400 


Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu 
                405                 410                 415     


Pro Thr Lys Lys Asp Ser Gln Ser Ser Val Ser Glu Asn Val Ser Asn 
            420                 425                 430         


Ser Gly Ile Asn Ser Ala Glu Ile Asp Ser Ser Gln Ile Ile Thr Ser 
        435                 440                 445             


Pro Leu Pro Ser Val Ser Ser Pro Pro Pro Ala Ser Lys Thr Lys Glu 
    450                 455                 460                 


Val Pro Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile 
465                 470                 475                 480 


Ser Arg Ala Cys Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr 
                485                 490                 495     


Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys 
            500                 505                 510         


Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu 
        515                 520                 525             


Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala 
    530                 535                 540                 


Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln 
545                 550                 555                 560 


Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu 
                565                 570                 575     


Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro 
            580                 585                 590         


Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr 
        595                 600                 605             


Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys 
    610                 615                 620                 


Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp 
625                 630                 635                 640 


Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys 
                645                 650                 655     


Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val 
            660                 665                 670         


Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val 
        675                 680                 685             


Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe 
    690                 695                 700                 


Arg Lys Tyr Ala Pro Ser Glu Asn Gly Pro Asn Gly Ile Ser Ala Glu 
705                 710                 715                 720 


Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr 
                725                 730                 735     


Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Leu Leu Thr 
            740                 745                 750         


Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg 
        755                 760                 765             


Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val 
    770                 775                 780                 


Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys 
785                 790                 795                 800 


Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile 
                805                 810                 815     


Leu Asn Leu Phe Ser Leu Met Val Asp Ala Asn Ile Pro Asp Ile Ala 
            820                 825                 830         


Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu 
        835                 840                 845             


Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp 
    850                 855                 860                 


Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys 
865                 870                 875                 880 


Phe Ala Gln Tyr Trp Arg Lys 
                885         


<210>  9236
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__AAH33004

<400>  9236
augggggaag cagagaaguu ucacuacauc uauaguugug accuggauau caacguccag       60

cuuaagauag gaagcuugga agggaagaga gaacaaaaga guuauaaagc uguccuggaa      120

gacccaaugu ugaaguucuc aggacuauau caagagacau gcucugaucu uuauguuacu      180

ugucaaguuu uugcagaagg gaagccuuug gccuugccag ugagaacauc cuacaaagca      240

uuuaguacaa gauggaacug gaaugaaugg cugaaacuac caguaaaaua cccugaccug      300

cccaggaaug cccaaguggc ccucaccaua ugggaugugu auggucccgg aaaagcagug      360

ccuguaggag gaacaacggu uucgcucuuu ggaaaauacg gcauguuucg ccaagggaug      420

caugacuuga aagucuggcc uaauguagaa gcagauggau cagaacccac aaaaacuccu      480

ggcagaacaa guagcacucu cucagaagau cagaugagcc gucuugccaa gcucaccaaa      540

gcucaucgac aaggacacau ggugaaagua gauuggcugg auagauugac auuuagagaa      600

auagaaauga uaaaugagag ugaaaaacga aguucuaauu ucauguaccu gaugguugaa      660

uuucgaugug ucaaguguga ugauaaggaa uaugguauug uuuauuauga aaaggacggu      720

gaugaaucau cuccaauuuu aacaaguuuu gaauuaguga aaguuccuga cccccagaug      780

ucuauggaga auuuaguuga gagcaaacac cacaagcuug cccggaguuu aagaagugga      840

ccuucugacc acgaucugaa acccaaugcu gccacgagag aucaguuaaa uauuauugug      900

aguuauccac caaccaagca acuuacauau gaagaacaag aucuuguuug gaaguuuaga      960

uauuaucuua cgaaucaaga aaaagccuug acaaaauucu ugaaaugugu uaauugggau     1020

cuaccucaag aggccaaaca ggccuuggaa cuucugggaa aauggaagcc gauggaugua     1080

gaggacuccu uggagcuguu auccucucau uacaccaacc caacugugag gcguuaugcu     1140

guugcccggu ugcgacaggc cgaugaugag gauuuguuga uguaccuauu acaauugguc     1200

caggcucuca aauaugaaaa uuuugaugau auaaagaaug gauuggaacc uaccaagaag     1260

gauagucaga guucaguguc agaaaaugug ucaaauucug gaauaaauuc ugcagaaaua     1320

gauagcuccc aaauuauaac cagcccccuu ccuucagucu cuucaccucc uccugcauca     1380

aaaacaaaag aaguuccaga uggcgaaaau cuggaacaag aucucuguac cuucuugaua     1440

ucgagagccu gcaaaaacuc aacacuggcu aauuauuuau acugguaugu gauaguggaa     1500

ugugaagauc aagauacuca gcagagagau ccaaagaccc augagaugua cuugaacgua     1560

augagaagau ucagccaagc auuguugaag ggugauaagu cugucagagu uaugcguucu     1620

uugcuggcug cacaacagac auuuguagau cgguuggugc aucuaaugaa ggcaguacaa     1680

cgcgaaagug gaaaucguaa gaaaaagaau gagagacuac aggcauugcu uggagauaau     1740

gaaaagauga auuugucaga uguggaacuu aucccguugc cuuuagaacc ccaagugaaa     1800

auuagaggaa uaauuccgga aacagcuaca cuguuuaaaa gugcccuuau gccugcacag     1860

uuguuuuuua agacggaaga uggaggcaaa uauccaguua uauuuaagca uggagaugau     1920

uuacgucaag aucaacuuau ucuucaaauc auuucacuca uggacaagcu guuacggaaa     1980

gaaaaucugg acuugaaauu gacaccuuau aagguguuag ccaccaguac aaaacauggc     2040

uucaugcagu uuauccaguc aguuccugug gcugaaguuc uugauacaga gggaagcauu     2100

cagaacuuuu uuagaaaaua ugcaccaagu gagaaugggc caaaugggau uagugcugag     2160

gucauggaca cuuacguuaa aagcugugcu ggauauugcg ugaucaccua uauacuugga     2220

guuggagaca ggcaccugga uaaccuuuug cuaacaaaaa caggcaaacu cuuccacaua     2280

gacuuuggau auauuuuggg ucgggaucca aagccucuuc cuccaccaau gaagcugaau     2340

aaagaaaugg uagaaggaau ggggggcaca cagagugagc aguaccaaga guuccguaaa     2400

caguguuaca cggcuuuccu ccaccugcga agguauucua aucugauuuu gaacuuguuu     2460

uccuugaugg uugaugcaaa cauuccagau auugcacuug aaccagauaa aacugugaaa     2520

aagguucagg auaaauuccg cuuagaccug ucggaugaag aggcugugca uuacaugcag     2580

agucugauug augagagugu ccaugcucuu uuugcugcag ugguggaaca gauucacaag     2640

uuugcccagu acuggagaaa auga                                            2664


<210>  9237
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__AAH33004

<400>  9237
augggcgagg ccgagaaguu ccacuacauc uacagcugcg accuggacau caacgugcag       60

cucaagaucg ggucccugga gggcaagcgc gagcagaagu ccuacaaggc cguccuggag      120

gaccccaugc ucaaguucuc cgggcuguac caggagaccu gcagcgaccu guacgugacc      180

ugccaggugu ucgcggaggg caagccccuc gcccugcccg uccggacguc cuacaaggcc      240

uucagcaccc gcuggaacug gaacgagugg cugaagcucc ccgugaagua ccccgaccug      300

ccgcggaacg cccagguggc ccugaccauc ugggacgucu acgggcccgg caaggcggug      360

cccgugggcg ggaccacggu cucccucuuc ggcaaguacg ggauguuccg ccagggcaug      420

cacgaccuga agguguggcc caacguggag gccgacggga gcgagccgac caagaccccc      480

ggccggaccu ccagcacgcu guccgaggac cagaugagcc gccucgccaa gcugaccaag      540

gcccaccggc agggccacau ggucaaggug gacuggcugg accgccucac cuuccgggag      600

aucgagauga ucaacgaguc cgagaagcgc agcuccaacu ucauguaccu gaugguggag      660

uuccggugcg ucaagugcga cgacaaggag uacgggaucg uguacuacga gaaggacggc      720

gacgagagcu cccccauccu gaccagcuuc gagcucguga agguccccga cccgcagaug      780

uccauggaga accuggugga gagcaagcac cacaagcugg cgcgcagccu ccgguccggg      840

cccagcgacc acgaccugaa gcccaacgcc gccacgcgcg accagcugaa caucaucgug      900

uccuacccgc ccaccaagca gcucaccuac gaggagcagg accuggucug gaaguuccgg      960

uacuaccuga ccaaccagga gaaggcccuc acgaaguucc ugaagugcgu gaacugggac     1020

cugccccagg aggccaagca ggcgcucgag cugcugggca aguggaagcc cauggacgug     1080

gaggacagcc ucgagcugcu guccagccac uacaccaacc ccaccguccg ccgguacgcc     1140

guggcccgcc uccggcaggc cgacgacgag gaccugcuga uguaccuccu gcagcugguc     1200

caggcccuca aguacgagaa cuucgacgac aucaagaacg gccuggagcc gaccaagaag     1260

gacucccaga gcuccgugag cgagaacgug uccaacagcg ggaucaacuc cgcggagauc     1320

gacagcuccc agaucaucac gagcccccug cccuccguca gcagcccgcc gcccgccagc     1380

aagaccaagg aggugcccga cggcgagaac cucgagcagg accugugcac cuuccugauc     1440

agccgcgccu gcaagaacuc cacccuggcc aacuaccucu acugguacgu gaucgucgag     1500

ugcgaggacc aggacacgca gcagcgggac cccaagaccc acgagaugua ccugaacgug     1560

augcgccgcu ucagccaggc ccugcucaag ggggacaagu ccgugcgggu caugcgcagc     1620

cugcuggcgg cccagcagac cuucguggac cggcucgugc accugaugaa ggccguccag     1680

cgcgaguccg gcaaccggaa gaagaagaac gagcgccugc aggcccuccu gggggacaac     1740

gagaagauga accugagcga cguggagcuc aucccccugc cccuggagcc ccaggugaag     1800

auccggggca ucaucccgga gaccgccacc cucuucaagu ccgcgcugau gcccgcccag     1860

cuguucuuca agacggagga cggcgggaag uaccccguca ucuucaagca cggcgacgac     1920

cuccgccagg accagcugau ccugcagauc aucagccuca uggacaagcu gcugcggaag     1980

gagaaccucg accugaagcu gacccccuac aaggugcucg ccaccuccac gaagcacggg     2040

uucaugcagu ucauccagag cgugccgguc gccgaggugc uggacaccga gggcuccauc     2100

cagaacuucu uccgcaagua cgcgcccagc gagaacgggc ccaacggcau cuccgccgag     2160

gugauggaca ccuacgucaa gagcugcgcc ggcuacugcg ugaucaccua cauccugggg     2220

gugggcgacc ggcaccucga caaccugcug cucacgaaga ccgggaagcu guuccacauc     2280

gacuucggcu acauccuggg gcgcgacccc aagccgcucc cgccgcccau gaagcugaac     2340

aaggagaugg ucgagggcau gggcgggacc caguccgagc aguaccagga guuccggaag     2400

cagugcuaca ccgccuuccu gcaccuccgc cgguacagca accugauccu gaaccucuuc     2460

ucccugaugg uggacgccaa cauccccgac aucgcgcugg agcccgacaa gaccgugaag     2520

aagguccagg acaaguuccg ccucgaccug agcgacgagg aggccgugca cuacaugcag     2580

agccugaucg acgaguccgu gcacgcccuc uucgccgccg ucguggagca gauccacaag     2640

uucgcgcagu acuggcggaa guga                                            2664


<210>  9238
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__AAH33004

<400>  9238
augggcgagg ccgagaaguu ccacuacauc uacuccugcg accucgacau caacguccag       60

cucaagaucg gcucccucga gggcaagcgc gagcagaagu ccuacaaggc cguccucgag      120

gaccccaugc ucaaguucuc cggccucuac caggagaccu gcuccgaccu cuacgucacc      180

ugccaggucu ucgccgaggg caagccccuc gcccuccccg uccgcaccuc cuacaaggcc      240

uucuccaccc gcuggaacug gaacgagugg cucaagcucc ccgucaagua ccccgaccuc      300

ccccgcaacg cccaggucgc ccucaccauc ugggacgucu acggccccgg caaggccguc      360

cccgucggcg gcaccaccgu cucccucuuc ggcaaguacg gcauguuccg ccagggcaug      420

cacgaccuca aggucuggcc caacgucgag gccgacggcu ccgagcccac caagaccccc      480

ggccgcaccu ccuccacccu cuccgaggac cagauguccc gccucgccaa gcucaccaag      540

gcccaccgcc agggccacau ggucaagguc gacuggcucg accgccucac cuuccgcgag      600

aucgagauga ucaacgaguc cgagaagcgc uccuccaacu ucauguaccu cauggucgag      660

uuccgcugcg ucaagugcga cgacaaggag uacggcaucg ucuacuacga gaaggacggc      720

gacgaguccu cccccauccu caccuccuuc gagcucguca agguccccga cccccagaug      780

uccauggaga accucgucga guccaagcac cacaagcucg cccgcucccu ccgcuccggc      840

cccuccgacc acgaccucaa gcccaacgcc gccacccgcg accagcucaa caucaucguc      900

uccuaccccc ccaccaagca gcucaccuac gaggagcagg accucgucug gaaguuccgc      960

uacuaccuca ccaaccagga gaaggcccuc accaaguucc ucaagugcgu caacugggac     1020

cucccccagg aggccaagca ggcccucgag cuccucggca aguggaagcc cauggacguc     1080

gaggacuccc ucgagcuccu cuccucccac uacaccaacc ccaccguccg ccgcuacgcc     1140

gucgcccgcc uccgccaggc cgacgacgag gaccuccuca uguaccuccu ccagcucguc     1200

caggcccuca aguacgagaa cuucgacgac aucaagaacg gccucgagcc caccaagaag     1260

gacucccagu ccuccgucuc cgagaacguc uccaacuccg gcaucaacuc cgccgagauc     1320

gacuccuccc agaucaucac cuccccccuc cccuccgucu ccuccccccc ccccgccucc     1380

aagaccaagg agguccccga cggcgagaac cucgagcagg accucugcac cuuccucauc     1440

ucccgcgccu gcaagaacuc cacccucgcc aacuaccucu acugguacgu caucgucgag     1500

ugcgaggacc aggacaccca gcagcgcgac cccaagaccc acgagaugua ccucaacguc     1560

augcgccgcu ucucccaggc ccuccucaag ggcgacaagu ccguccgcgu caugcgcucc     1620

cuccucgccg cccagcagac cuucgucgac cgccucgucc accucaugaa ggccguccag     1680

cgcgaguccg gcaaccgcaa gaagaagaac gagcgccucc aggcccuccu cggcgacaac     1740

gagaagauga accucuccga cgucgagcuc aucccccucc cccucgagcc ccaggucaag     1800

auccgcggca ucauccccga gaccgccacc cucuucaagu ccgcccucau gcccgcccag     1860

cucuucuuca agaccgagga cggcggcaag uaccccguca ucuucaagca cggcgacgac     1920

cuccgccagg accagcucau ccuccagauc aucucccuca uggacaagcu ccuccgcaag     1980

gagaaccucg accucaagcu cacccccuac aagguccucg ccaccuccac caagcacggc     2040

uucaugcagu ucauccaguc cguccccguc gccgaggucc ucgacaccga gggcuccauc     2100

cagaacuucu uccgcaagua cgcccccucc gagaacggcc ccaacggcau cuccgccgag     2160

gucauggaca ccuacgucaa guccugcgcc ggcuacugcg ucaucaccua cauccucggc     2220

gucggcgacc gccaccucga caaccuccuc cucaccaaga ccggcaagcu cuuccacauc     2280

gacuucggcu acauccucgg ccgcgacccc aagccccucc ccccccccau gaagcucaac     2340

aaggagaugg ucgagggcau gggcggcacc caguccgagc aguaccagga guuccgcaag     2400

cagugcuaca ccgccuuccu ccaccuccgc cgcuacucca accucauccu caaccucuuc     2460

ucccucaugg ucgacgccaa cauccccgac aucgcccucg agcccgacaa gaccgucaag     2520

aagguccagg acaaguuccg ccucgaccuc uccgacgagg aggccgucca cuacaugcag     2580

ucccucaucg acgaguccgu ccacgcccuc uucgccgccg ucgucgagca gauccacaag     2640

uucgcccagu acuggcgcaa guga                                            2664


<210>  9239
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__AAH33004

<400>  9239
augggcgagg ccgaaaaguu ccacuacauc uauagcugcg accuggauau uaacgugcag       60

cucaaaauag ggucccuuga gggaaagaga gaacaaaaau cuuacaaggc uguccuggag      120

gaccccaugu ugaaauuuuc agguuuauau caggaaaccu guagugaucu guacguuaca      180

ugccaggugu ucgcagaggg caagccucua gcccucccag uaaggacuag cuauaaggcg      240

uuuuccacgc gguggaauug gaacgagugg cugaaacuuc cggugaagua ccccgaccug      300

ccucgcaaug cucaggucgc cuugaccauc ugggaugugu augggccagg aaaagcaguu      360

cccgugggcg guacaacugu cucucucuuc gggaaguacg gaauguuucg acaaggcaug      420

caugaccuga aaguguggcc uaacguagaa gccgauggcu cggagccaac caagacaccc      480

gggcguaccu caagcacucu gagugaagac cagaugucca gacucgcuaa guuaacaaaa      540

gcacacaggc agggacauau gguuaaggug gauuggcugg accggcuuac cuuccgcgag      600

auugagauga ucaaugaauc ugagaaaaga agcuccaacu uuauguacuu gauggucgag      660

uucaggugug ugaagugcga ugacaaagag uaugguauug uguacuauga aaaggauggc      720

gacgagucaa guccuauccu gacgagcuuu gagcuaguca aaguuccaga cccgcagaug      780

ucuauggaaa aucucgugga guccaagcac cauaagcugg cccggucacu ucgcagcggg      840

cccagugauc acgaccugaa accuaacgcu gccacucgag aucaauugaa uauaaucgua      900

ucuuacccac ccaccaagca gcucacauau gaagaacagg accuggugug gaaauucaga      960

uacuauuuaa cuaaccagga aaaggcgcug accaaauuuc ucaagugugu caauugggau     1020

cuuccucaag aggcaaagca ggcccuggag uugcuaggaa aauggaagcc aauggacgug     1080

gaagauuccc uggagcuccu gagcucgcac uacacaaacc ccaccguuag gcgguacgcu     1140

guggcccguc uucgccaggc agacgaugaa gaccuguuga uguaucuccu gcaauuaguc     1200

caggcucuga aauacgagaa uuucgaugac auuaagaacg gccuagaacc gacgaaaaag     1260

gacucucagu ccucagugag ugagaaugua agcaacuccg guaucaacuc ugccgagauu     1320

gauagcucac agaucauaac aaguccucuc cccuccguua gcucuccacc ucccgcguca     1380

aagacuaaag aagugccaga cggggagaau cuggaacaag aucuuugcac cuuuuugauu     1440

aguagagccu guaagaacag cacucuggca aauuaucucu acugguaugu caucguggag     1500

ugcgaggacc aggauacaca gcagagggac cccaaaaccc augaaaugua ccugaacguc     1560

augcggcgau ucucccaagc ucugcugaag ggagauaaau cugugcgcgu uaugagaucg     1620

uugcucgccg cucagcagac guucguggac aggcugguac acuuaaugaa ggccguccag     1680

cgggagagcg gcaaucgcaa gaaaaagaac gaaagacugc aagcacuacu cggcgauaau     1740

gagaaaauga accuguccga cguggaacuu auuccuuugc cacuggagcc gcagguuaag     1800

aucaggggga ucauucccga gaccgccaca cucuuuaaau cagcucugau gccugcgcag     1860

uuauucuuua agacugaaga uggagguaaa uauccaguga uauucaagca uggcgacgau     1920

cugcgucagg accaacuuau cuugcagauu aucagucuca uggacaagcu gcuacggaaa     1980

gagaaucugg aucucaagcu gacccccuac aaaguccuug caacaucuac uaagcacggg     2040

uuuaugcagu ucauacaaag cgugccugua gccgaagugu uggacaccga gggauccauu     2100

cagaacuuuu uccgaaaaua cgcuccauca gaaaauggcc ccaacgguau cagcgccgag     2160

guuauggaua cauaugucaa gucuugugca ggguacugcg ugaucaccua uauucugggc     2220

gugggagaca gacacuuaga uaaucuccug cuuacuaaga cgggcaaacu guuucauauc     2280

gacuucgggu acauuuuggg aagggauccg aagccucucc cacccccuau gaaacugaac     2340

aaggagaugg ucgaagguau gggcgggaca caguccgagc aguaucaaga auuucgcaaa     2400

caguguuaca ccgccuuccu acaccuucgg agauauagua aucucauacu gaaccuuuuu     2460

agcuugaugg uugacgcuaa cauccccgau auugcccugg agccagacaa gacugugaag     2520

aaagugcagg auaaguucag guuagaccuc ucugaugaag aggcaguaca uuacaugcag     2580

ucccugaucg acgagucagu ccacgcgcuu uucgcugccg ugguugaaca aauccauaaa     2640

uuugcacagu acuggcgcaa guga                                            2664


<210>  9240
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__AAH33004

<400>  9240
augggcgagg ccgagaaguu ccacuacauc uacagcugcg accuggacau caacgugcag       60

cugaagaucg gcagccugga gggcaagaga gagcagaaga gcuacaaggc cgugcuggag      120

gaccccaugc ugaaguucag cggccuguac caggagaccu gcagcgaccu guacgugacc      180

ugccaggugu ucgccgaggg caagccccug gcccugcccg ugagaaccag cuacaaggcc      240

uucagcacca gauggaacug gaacgagugg cugaagcugc ccgugaagua ccccgaccug      300

cccagaaacg cccagguggc ccugaccauc ugggacgugu acggccccgg caaggccgug      360

cccgugggcg gcaccaccgu gagccuguuc ggcaaguacg gcauguucag acagggcaug      420

cacgaccuga agguguggcc caacguggag gccgacggca gcgagcccac caagaccccc      480

ggcagaacca gcagcacccu gagcgaggac cagaugagca gacuggccaa gcugaccaag      540

gcccacagac agggccacau ggugaaggug gacuggcugg acagacugac cuucagagag      600

aucgagauga ucaacgagag cgagaagaga agcagcaacu ucauguaccu gaugguggag      660

uucagaugcg ugaagugcga cgacaaggag uacggcaucg uguacuacga gaaggacggc      720

gacgagagca gccccauccu gaccagcuuc gagcugguga aggugcccga cccccagaug      780

agcauggaga accuggugga gagcaagcac cacaagcugg ccagaagccu gagaagcggc      840

cccagcgacc acgaccugaa gcccaacgcc gccaccagag accagcugaa caucaucgug      900

agcuaccccc ccaccaagca gcugaccuac gaggagcagg accuggugug gaaguucaga      960

uacuaccuga ccaaccagga gaaggcccug accaaguucc ugaagugcgu gaacugggac     1020

cugccccagg aggccaagca ggcccuggag cugcugggca aguggaagcc cauggacgug     1080

gaggacagcc uggagcugcu gagcagccac uacaccaacc ccaccgugag aagauacgcc     1140

guggccagac ugagacaggc cgacgacgag gaccugcuga uguaccugcu gcagcuggug     1200

caggcccuga aguacgagaa cuucgacgac aucaagaacg gccuggagcc caccaagaag     1260

gacagccaga gcagcgugag cgagaacgug agcaacagcg gcaucaacag cgccgagauc     1320

gacagcagcc agaucaucac cagcccccug cccagcguga gcagcccccc ccccgccagc     1380

aagaccaagg aggugcccga cggcgagaac cuggagcagg accugugcac cuuccugauc     1440

agcagagccu gcaagaacag cacccuggcc aacuaccugu acugguacgu gaucguggag     1500

ugcgaggacc aggacaccca gcagagagac cccaagaccc acgagaugua ccugaacgug     1560

augagaagau ucagccaggc ccugcugaag ggcgacaaga gcgugagagu gaugagaagc     1620

cugcuggccg cccagcagac cuucguggac agacuggugc accugaugaa ggccgugcag     1680

agagagagcg gcaacagaaa gaagaagaac gagagacugc aggcccugcu gggcgacaac     1740

gagaagauga accugagcga cguggagcug aucccccugc cccuggagcc ccaggugaag     1800

aucagaggca ucauccccga gaccgccacc cuguucaaga gcgcccugau gcccgcccag     1860

cuguucuuca agaccgagga cggcggcaag uaccccguga ucuucaagca cggcgacgac     1920

cugagacagg accagcugau ccugcagauc aucagccuga uggacaagcu gcugagaaag     1980

gagaaccugg accugaagcu gacccccuac aaggugcugg ccaccagcac caagcacggc     2040

uucaugcagu ucauccagag cgugcccgug gccgaggugc uggacaccga gggcagcauc     2100

cagaacuucu ucagaaagua cgcccccagc gagaacggcc ccaacggcau cagcgccgag     2160

gugauggaca ccuacgugaa gagcugcgcc ggcuacugcg ugaucaccua cauccugggc     2220

gugggcgaca gacaccugga caaccugcug cugaccaaga ccggcaagcu guuccacauc     2280

gacuucggcu acauccuggg cagagacccc aagccccugc ccccccccau gaagcugaac     2340

aaggagaugg uggagggcau gggcggcacc cagagcgagc aguaccagga guucagaaag     2400

cagugcuaca ccgccuuccu gcaccugaga agauacagca accugauccu gaaccuguuc     2460

agccugaugg uggacgccaa cauccccgac aucgcccugg agcccgacaa gaccgugaag     2520

aaggugcagg acaaguucag acuggaccug agcgacgagg aggccgugca cuacaugcag     2580

agccugaucg acgagagcgu gcacgcccug uucgccgccg ugguggagca gauccacaag     2640

uucgcccagu acuggagaaa guga                                            2664


<210>  9241
<211>  2664
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__AAH33004

<400>  9241
augggcgagg ccgaaaaguu ccacuacauc uauagcugcg accuggauau uaacgugcag       60

cucaaaaucg ggucccugga gggaaagaga gaacaaaaau cuuacaaggc uguccuugag      120

gaccccaugc ugaaauuuag cggccucuau caggaaaccu guuccgaucu guacguuaca      180

ugccaggugu ucgccgaggg gaagccucuu gcgcugccgg ugcggacguc uuauaaggcu      240

uuuagcaccc gcuggaauug gaacgagugg cucaaacugc ccgucaagua cccugaccug      300

cccagaaaug cccagguggc ccucacaauu ugggauguuu auggaccugg caaagcugug      360

cccgucgggg gaaccacagu gucccuguuc ggcaaguacg gcauguuucg gcaagggaug      420

caugaccuua aaguuuggcc uaacguggaa gccgauggau cugagccgac caagacaccc      480

ggccgcacca gcuccacgcu gagcgaagac cagaugucua gacucgcuaa gcugaccaaa      540

gcccaccggc aggggcauau ggucaaggug gauuggcuug accgccugac auucagagag      600

aucgagauga uuaaugaauc cgagaaacgg agcucuaacu uuauguaccu caugguggag      660

uuccgcugug ucaagugcga ugacaaagag uauggaaucg uuuacuauga aaaggauggc      720

gacgagucca gcccuauccu gaccucuuuu gagcugguga aagugcccga cccucagaug      780

uccauggaaa aucucgucga gagcaagcac cauaagcugg cgagaucccu ucggucuggg      840

cccagcgauc acgaccugaa accgaacgcc gcuacacgcg aucaacucaa uauuaucgug      900

uccuacccuc ccaccaagca gcugacguau gaagaacagg accuuguuug gaaauucaga      960

uacuaucuga caaaccagga aaaggcccuc accaaauuuc ugaagugugu gaauugggau     1020

cugccucaag aggcuaagca ggcccucgag cugcuuggaa aauggaagcc cauggacguc     1080

gaagauagcc uggagcuccu gucuucccac uacacaaacc ccaccgugcg gcgcuacgcg     1140

guugccagac uucggcaggc ugacgaugaa gaccugcuca uguaucugcu gcaacucgug     1200

caggcccuga aauacgagaa uuucgaugac auuaagaacg gccuugaacc uaccaaaaag     1260

gacagccagu cuagcgucuc cgagaaugug ucuaacagcg gcaucaacuc cgcugagauu     1320

gauagcucuc agaucauuac auccccgcug cccagcgucu cuuccccucc cccugccagc     1380

aagacgaaag aagugcccga cggggagaau cucgaacaag aucugugcac cuuucugauc     1440

uccagagccu guaagaacuc uacacuugcu aauuaucucu acugguaugu uaucguggag     1500

ugcgaggacc aggauaccca gcagcgcgac ccgaaaacac augaaaugua ccugaacguc     1560

augcggagau ucagccaagc gcugcucaag ggagauaaau ccgugcgcgu uaugcggucu     1620

cugcuugccg cucagcagac cuucguggac agacuggucc accucaugaa ggccgugcag     1680

cgcgagagcg gcaaucggaa gaaaaagaac gaaagacugc aagcccugcu uggggauaau     1740

gagaaaauga accucuccga cguggaacug auuccucugc cccucgagcc ucagguuaag     1800

auccgcggaa uuauccccga gacggcuaca cuguuuaaaa gcgcccuuau gccugcgcag     1860

cuguucuuua agaccgaaga uggcgggaaa uaucccguca uuuucaagca uggagacgau     1920

cuccggcagg accaacugau ccugcagauc auuucucuua uggacaagcu ccugagaaaa     1980

gagaaucugg aucucaagcu gaccccguac aaagugcuug cuacauccac caagcacggc     2040

uuuaugcagu ucauccaaag cgugccuguc gccgaagugc uggacacaga gggcucuauu     2100

cagaacuuuu uccgcaaaua cgcccccucc gaaaaugggc ccaacggaau cagcgcugag     2160

guuauggaua cguaugugaa gucuugugcc ggcuacugcg ucauuaccua uauccucggg     2220

gugggagacc ggcaccugga uaaucugcuu cucacaaaga ccggcaaacu guuucauauc     2280

gacuucgggu acauucuggg cagagauccu aagccgcugc ccccucccau gaaacugaac     2340

aaggagaugg uugaaggaau gggcgggaca cagagcgagc aguaucaaga auuucggaaa     2400

caguguuaca ccgcuuuccu ucaccuccgc agauauucca aucucauccu gaaccuguuu     2460

agccuuaugg uggacgccaa cauuccugau aucgcgcugg agcccgacaa gacggucaag     2520

aaagugcagg auaaguuccg gcucgaccug ucugaugaag aggccguuca uuacaugcag     2580

ucccucauug acgagagcgu gcacgcucug uucgccgcug ucguggaaca aauccauaaa     2640

uuugcccagu acuggagaaa guga                                            2664


<210>  9242
<211>  880
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__Q8WYR1

<400>  9242

Met Gln Pro Gly Ala Thr Thr Cys Thr Glu Asp Arg Ile Gln His Ala 
1               5                   10                  15      


Leu Glu Arg Cys Leu His Gly Leu Ser Leu Ser Arg Arg Ser Thr Ser 
            20                  25                  30          


Trp Ser Ala Gly Leu Cys Leu Asn Cys Trp Ser Leu Gln Glu Leu Val 
        35                  40                  45              


Ser Arg Asp Pro Gly His Phe Leu Ile Leu Leu Glu Gln Ile Leu Gln 
    50                  55                  60                  


Lys Thr Arg Glu Val Gln Glu Lys Gly Thr Tyr Asp Leu Leu Thr Pro 
65                  70                  75                  80  


Leu Ala Leu Leu Phe Tyr Ser Thr Val Leu Cys Thr Pro His Phe Pro 
                85                  90                  95      


Pro Asp Ser Asp Leu Leu Leu Lys Ala Ala Ser Thr Tyr His Arg Phe 
            100                 105                 110         


Leu Thr Trp Pro Val Pro Tyr Cys Ser Ile Cys Gln Glu Leu Leu Thr 
        115                 120                 125             


Phe Ile Asp Ala Glu Leu Lys Ala Pro Gly Ile Ser Tyr Gln Arg Leu 
    130                 135                 140                 


Val Arg Ala Glu Gln Gly Leu Pro Ile Arg Ser His Arg Ser Ser Thr 
145                 150                 155                 160 


Val Thr Val Leu Leu Leu Asn Pro Val Glu Val Gln Ala Glu Phe Leu 
                165                 170                 175     


Ala Val Ala Asn Lys Leu Ser Thr Pro Gly His Ser Pro His Ser Ala 
            180                 185                 190         


Tyr Thr Thr Leu Leu Leu His Ala Phe Gln Ala Thr Phe Gly Ala His 
        195                 200                 205             


Cys Asp Val Pro Gly Leu His Cys Arg Leu Gln Ala Lys Thr Leu Ala 
    210                 215                 220                 


Glu Leu Glu Asp Ile Phe Thr Glu Thr Ala Glu Ala Gln Glu Leu Ala 
225                 230                 235                 240 


Ser Gly Ile Gly Asp Ala Ala Glu Ala Arg Arg Trp Leu Arg Thr Lys 
                245                 250                 255     


Leu Gln Ala Val Gly Glu Lys Ala Gly Phe Pro Gly Val Leu Asp Thr 
            260                 265                 270         


Ala Lys Pro Gly Lys Leu His Thr Ile Pro Ile Pro Val Ala Arg Cys 
        275                 280                 285             


Tyr Thr Tyr Ser Trp Ser Gln Asp Ser Phe Asp Ile Leu Gln Glu Ile 
    290                 295                 300                 


Leu Leu Lys Glu Gln Glu Leu Leu Gln Pro Gly Ile Leu Gly Asp Asp 
305                 310                 315                 320 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Asp Leu Glu Thr 
                325                 330                 335     


Asp Gly His Cys Ala Glu Arg Asp Ser Leu Leu Ser Thr Ser Ser Leu 
            340                 345                 350         


Ala Ser His Asp Ser Thr Leu Ser Leu Ala Ser Ser Gln Ala Ser Gly 
        355                 360                 365             


Pro Ala Leu Ser Arg His Leu Leu Thr Ser Phe Val Ser Gly Leu Ser 
    370                 375                 380                 


Asp Gly Met Asp Ser Gly Tyr Val Glu Asp Ser Glu Glu Ser Ser Ser 
385                 390                 395                 400 


Glu Trp Pro Trp Arg Arg Gly Ser Gln Glu Arg Arg Gly His Arg Arg 
                405                 410                 415     


Pro Gly Gln Lys Phe Ile Arg Ile Tyr Lys Leu Phe Lys Ser Thr Ser 
            420                 425                 430         


Gln Leu Val Leu Arg Arg Asp Ser Arg Ser Leu Glu Gly Ser Ser Asp 
        435                 440                 445             


Thr Ala Leu Pro Leu Arg Arg Ala Gly Ser Leu Cys Ser Pro Leu Asp 
    450                 455                 460                 


Glu Pro Val Ser Pro Pro Ser Arg Ala Gln Arg Ser Arg Ser Leu Pro 
465                 470                 475                 480 


Gln Pro Lys Leu Gly Thr Gln Leu Pro Ser Trp Leu Leu Ala Pro Ala 
                485                 490                 495     


Ser Arg Pro Gln Arg Arg Arg Pro Phe Leu Ser Gly Asp Glu Asp Pro 
            500                 505                 510         


Lys Ala Ser Thr Leu Arg Val Val Val Phe Gly Ser Asp Arg Ile Ser 
        515                 520                 525             


Gly Lys Val Ala Arg Ala Tyr Ser Asn Leu Arg Arg Leu Glu Asn Asn 
    530                 535                 540                 


Arg Pro Leu Leu Thr Arg Phe Phe Lys Leu Gln Phe Phe Tyr Val Pro 
545                 550                 555                 560 


Val Lys Arg Ser His Gly Thr Ser Pro Gly Ala Cys Pro Pro Pro Arg 
                565                 570                 575     


Ser Gln Thr Pro Ser Pro Pro Thr Asp Ser Pro Arg His Ala Ser Pro 
            580                 585                 590         


Gly Glu Leu Gly Thr Thr Pro Trp Glu Glu Ser Thr Asn Asp Ile Ser 
        595                 600                 605             


His Tyr Leu Gly Met Leu Asp Pro Trp Tyr Glu Arg Asn Val Leu Gly 
    610                 615                 620                 


Leu Met His Leu Pro Pro Glu Val Leu Cys Gln Gln Ser Leu Lys Ala 
625                 630                 635                 640 


Glu Ala Gln Ala Leu Glu Gly Ser Pro Thr Gln Leu Pro Ile Leu Ala 
                645                 650                 655     


Asp Met Leu Leu Tyr Tyr Cys Arg Phe Ala Ala Arg Pro Val Leu Leu 
            660                 665                 670         


Gln Val Tyr Gln Thr Glu Leu Thr Phe Ile Thr Gly Glu Lys Thr Thr 
        675                 680                 685             


Glu Ile Phe Ile His Ser Leu Glu Leu Gly His Ser Ala Ala Thr Arg 
    690                 695                 700                 


Ala Ile Lys Ala Ser Gly Pro Gly Ser Lys Arg Leu Gly Ile Asp Gly 
705                 710                 715                 720 


Asp Arg Glu Ala Val Pro Leu Thr Leu Gln Ile Ile Tyr Ser Lys Gly 
                725                 730                 735     


Ala Ile Ser Gly Arg Ser Arg Trp Ser Asn Leu Glu Lys Val Cys Thr 
            740                 745                 750         


Ser Val Asn Leu Asn Lys Ala Cys Arg Lys Gln Glu Glu Leu Asp Ser 
        755                 760                 765             


Ser Met Glu Ala Leu Thr Leu Asn Leu Thr Glu Val Val Lys Arg Gln 
    770                 775                 780                 


Asn Ser Lys Ser Lys Lys Gly Phe Asn Gln Ile Ser Thr Ser Gln Ile 
785                 790                 795                 800 


Lys Val Asp Lys Val Gln Ile Ile Gly Ser Asn Ser Cys Pro Phe Ala 
                805                 810                 815     


Val Cys Leu Asp Gln Asp Glu Arg Lys Ile Leu Gln Ser Val Val Arg 
            820                 825                 830         


Cys Glu Val Ser Pro Cys Tyr Lys Pro Glu Lys Ser Asp Leu Ser Ser 
        835                 840                 845             


Pro Pro Gln Thr Pro Pro Asp Leu Pro Ala Gln Ala Ala Pro Asp Leu 
    850                 855                 860                 


Cys Ser Leu Leu Cys Leu Pro Ile Met Thr Phe Ser Gly Ala Leu Pro 
865                 870                 875                 880 






<210>  9243
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PI3K__Homo_sapiens__ABY87553

<400>  9243
augcagccag gggccacgac augcacggag gaccgcaucc agcaugcccu ggaacgcugc       60

cugcauggac ucagccucag ccgccgcucc accuccuggu cagcugggcu gugucugaac      120

ugcuggagcc ugcaggagcu ggucagcagg gacccgggcc acuuccuuau ccuccuugag      180

cagauccugc agaagacccg agagguccag gagaagggca ccuacgaccu gcucaccccg      240

cuggcccugc ucuucuauuc cacuguucuu uguacaccac acuucccacc agacucggau      300

cuccuucuga aggcagccag caccuaccac cgguuccuga ccuggccugu uccuuacugc      360

agcaucugcc aggagcugcu caccuucauu gaugcugaac ucaaggcccc agggaucucc      420

uaccagagac uggugagggc ugagcagggc cugcccauca ggagucaccg cagcuccacc      480

gucaccgugc ugcugcugaa cccaguggaa gugcaggccg aguuccuugc uguagccaau      540

aagcugagua cgcccggaca cucgccucac agugccuaca ccacccugcu ccugcacgcc      600

uuccaggcca ccuuuggggc ccacugugac gucccgggcc ugcacugcag gcuacaggcc      660

aagacccugg cagagcuuga ggacaucuuc acggagaccg cagaggcaca ggagcuggca      720

ucuggcaucg gggaugcugc agaggcccgg cgguggcuca ggaccaagcu gcaggcggug      780

ggagaaaaag cuggcuuccc ugggguguua gacacugcaa aaccagggaa gcuccauacc      840

auccccaucc cugucgccag gugcuacacc uacagcugga gccaggacag cuuugacauc      900

cugcaggaaa uccugcucaa ggaacaggag cuacuccagc cagggauccu gggagaugau      960

gaagaggagg aagaggagga ggaggaggug gaggaggacu uggaaacuga cgggcacugu     1020

gccgagagag auucccugcu cuccaccagc ucuuuggcgu cccaugacuc cacccugucc     1080

cuugcauccu cccaggccuc ggggccggcc cucucgcgcc aucugcugac uuccuuuguc     1140

ucaggccucu cugauggcau ggacagcggc uacguggagg acagcgagga gagcuccucc     1200

gaguggccuu ggaggcgugg cagccaggaa cgccgaggcc accgcaggcc ugggcagaag     1260

uucaucagga ucuauaaacu cuucaagagc accagccagc ugguacugcg gagggacucu     1320

cggagccugg agggcagcuc ggacacggcc cugccccuga ggcgggcagg gagccucugc     1380

agcccccugg acgaaccagu aucacccccu ucccgggccc agcgcucccg cucccugccc     1440

cagcccaaac ucgguaccca gcugcccagc uggcuucugg ccccugcuuc acgcccccag     1500

cgccgccgcc ccuuccugag uggagaugag gaucccaagg cuuccacgcu acguguugug     1560

gucuuuggcu ccgaucggau uucagggaag guggcucggg cguacagcaa ccuucggcgg     1620

cuggagaaca aucgcccacu ccucacacgg uucuucaaac uucaguucuu cuacgugccu     1680

gugaagcgaa gucaugggac cagcccuggu gccuguccac ccccucggag ccagacgccc     1740

ucacccccga cagacucccc uaggcacgcc agcccuggag agcugggcac caccccaugg     1800

gaggagagca ccaaugacau cucccacuac cucggcaugc uggaccccug guaugagcgc     1860

aauguacugg gccucaugca ccugcccccu gaaguccugu gccagcaguc ccugaaggcu     1920

gaagcccagg cccuggaggg cuccccaacc cagcugccca uccuggcuga caugcuacuc     1980

uacuacugcc gcuuugccgc cagaccggug cugcugcaag ucuaucagac cgagcugacc     2040

uucaucacug gggagaagac gacagagauc uucauccacu ccuuggagcu gggucacucc     2100

gcugccacac gugccaucaa ggcgucaggu ccuggcagca agcggcuggg caucgauggc     2160

gaccgggagg cuguuccucu aacacuacag auuauuuaca gcaagggggc caucagugga     2220

cgaagucgcu ggagcaaccu ggagaagguc uguaccuccg ugaaccucaa caaggccugc     2280

cggaagcagg aggagcugga uuccagcaug gaggcccuga cgcuaaaccu gacagaagug     2340

gugaaaaggc agaacuccaa auccaagaag ggcuuuaacc agauuagcac aucgcagauc     2400

aaaguggaca aggugcagau caucggcucc aacagcugcc ccuuugcugu gugccuggac     2460

caggaugaga gaaagauccu gcagagugua gucagaugug aggucucacc gugcuacaag     2520

ccagagaaga gcgaccucuc cucaccaccc cagacgccuc cugaccugcc ggcccaggcc     2580

gcaccugauc ucugcucccu ucucugccug cccaucauga cuuucagugg agcucugccc     2640

uag                                                                   2643


<210>  9244
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PI3K__Homo_sapiens__ABY87553

<400>  9244
augcagcccg gcgccacgac cugcacggag gaccgcaucc agcacgcccu ggagcggugc       60

cuccacgggc ugagccuguc ccgccggagc accuccugga gcgcgggccu cugccugaac      120

ugcugguccc ugcaggagcu cgugagccgc gacccggggc acuuccugau ccugcucgag      180

cagauccugc agaagacccg ggagguccag gagaagggca ccuacgaccu gcucacgccc      240

cuggcccucc ucuucuacuc caccgugcug ugcacgcccc acuucccgcc cgacagcgac      300

cugcuccuga aggccgccuc caccuaccac cgcuuccuga ccuggcccgu gcccuacugc      360

agcaucugcc aggagcuccu gaccuucauc gacgccgagc ugaaggcgcc cgggaucucc      420

uaccagcggc ucguccgcgc cgagcagggc cugccgaucc ggagccaccg cuccagcacc      480

gugaccgugc ugcuccugaa ccccgucgag gugcaggccg aguuccuggc cguggcgaac      540

aagcucucca cgcccggcca cagcccccac uccgccuaca ccacccugcu gcuccacgcc      600

uuccaggcca ccuucggggc ccacugcgac gucccgggcc ugcacugccg gcugcaggcg      660

aagacgcucg ccgagcugga ggacaucuuc accgagaccg ccgaggccca ggagcuggcc      720

agcgggaucg gcgacgcggc cgaggcccgc cgguggcucc gcaccaagcu gcaggccgug      780

ggggagaagg ccggcuuccc cggcgugcug gacacggcga agcccgggaa gcuccacacc      840

auccccaucc cggucgcccg gugcuacacc uacuccugga gccaggacag cuucgacauc      900

cugcaggaga uccugcugaa ggagcaggag cugcugcagc ccggcauccu cggggacgac      960

gaggaggagg aggaggagga ggaggaggug gaggaggacc uggagaccga cggccacugc     1020

gccgagcgcg acucccugcu gagcaccucc agccucgccu cccacgacag cacccugucc     1080

cuggccagcu cccaggcgag cggccccgcc cucucccggc accuccugac cagcuucgug     1140

uccgggcuga gcgacggcau ggacuccggg uacgucgagg acagcgagga guccagcucc     1200

gaguggcccu ggcgccgggg cagccaggag cgccgggggc accgccgccc gggccagaag     1260

uucauccgga ucuacaagcu guucaagagc accucccagc uggugcuccg ccgggacagc     1320

cgcucccugg agggcagcuc cgacacggcc cugccccucc ggcgcgccgg gagccugugc     1380

agcccccugg acgagcccgu guccccgccc ucccgggcgc agcgcagccg gucccucccc     1440

cagcccaagc ugggcaccca gcugccgagc uggcuccugg cccccgccuc ccgcccccag     1500

cggcgccggc cguuccugag cggggacgag gaccccaagg ccuccacccu ccgcgucgug     1560

guguucggca gcgaccggau cuccgggaag gucgcccgcg cguacagcaa ccugcggcgc     1620

cuggagaaca accggccccu ccugacccgc uucuucaagc ugcaguucuu cuacgugccc     1680

gugaagcgca gccacggcac guccccgggc gccugcccgc cgccccggag ccagaccccc     1740

uccccgccca ccgacagccc ccgccacgcc ucccccgggg agcucggcac cacgcccugg     1800

gaggagagca ccaacgacau cucccacuac cuggggaugc uggaccccug guacgagcgg     1860

aacguccucg gccugaugca ccucccgccc gaggugcugu gccagcagag ccugaaggcc     1920

gaggcccagg cgcuggaggg gucccccacc cagcucccca uccuggccga caugcugcuc     1980

uacuacugcc gcuucgccgc ccggcccguc cugcuccagg uguaccagac cgagcugacc     2040

uucaucacgg gcgagaagac caccgagauc uucauccaca gccuggagcu gggccacucc     2100

gccgcgaccc gcgccaucaa ggccagcggg cccggcucca agcggcucgg gaucgacggc     2160

gaccgcgagg ccgugccccu gacgcugcag aucaucuaca gcaagggcgc gaucuccggg     2220

cggagccgcu gguccaaccu cgagaagguc ugcaccagcg ugaaccugaa caaggccugc     2280

cggaagcagg aggagcugga cuccagcaug gaggcccuca cccugaaccu gaccgaggug     2340

gucaagcgcc agaacagcaa guccaagaag ggcuucaacc agaucagcac gucccagauc     2400

aagguggaca aggugcagau caucgggagc aacuccugcc ccuucgccgu cugccucgac     2460

caggacgagc ggaagauccu gcagagcgug gugcgcugcg aggucucccc cugcuacaag     2520

ccggagaagu ccgaccugag cagcccgccc cagaccccgc ccgaccuccc cgcccaggcg     2580

gcccccgacc ugugcucccu gcucugccug cccaucauga ccuucagcgg cgcccugccc     2640

uga                                                                   2643


<210>  9245
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PI3K__Homo_sapiens__ABY87553

<400>  9245
augcagcccg gcgccaccac cugcaccgag gaccgcaucc agcacgcccu cgagcgcugc       60

cuccacggcc ucucccucuc ccgccgcucc accuccuggu ccgccggccu cugccucaac      120

ugcugguccc uccaggagcu cgucucccgc gaccccggcc acuuccucau ccuccucgag      180

cagauccucc agaagacccg cgagguccag gagaagggca ccuacgaccu ccucaccccc      240

cucgcccucc ucuucuacuc caccguccuc ugcacccccc acuucccccc cgacuccgac      300

cuccuccuca aggccgccuc caccuaccac cgcuuccuca ccuggcccgu ccccuacugc      360

uccaucugcc aggagcuccu caccuucauc gacgccgagc ucaaggcccc cggcaucucc      420

uaccagcgcc ucguccgcgc cgagcagggc cuccccaucc gcucccaccg cuccuccacc      480

gucaccgucc uccuccucaa ccccgucgag guccaggccg aguuccucgc cgucgccaac      540

aagcucucca cccccggcca cuccccccac uccgccuaca ccacccuccu ccuccacgcc      600

uuccaggcca ccuucggcgc ccacugcgac guccccggcc uccacugccg ccuccaggcc      660

aagacccucg ccgagcucga ggacaucuuc accgagaccg ccgaggccca ggagcucgcc      720

uccggcaucg gcgacgccgc cgaggcccgc cgcuggcucc gcaccaagcu ccaggccguc      780

ggcgagaagg ccggcuuccc cggcguccuc gacaccgcca agcccggcaa gcuccacacc      840

auccccaucc ccgucgcccg cugcuacacc uacuccuggu cccaggacuc cuucgacauc      900

cuccaggaga uccuccucaa ggagcaggag cuccuccagc ccggcauccu cggcgacgac      960

gaggaggagg aggaggagga ggaggagguc gaggaggacc ucgagaccga cggccacugc     1020

gccgagcgcg acucccuccu cuccaccucc ucccucgccu cccacgacuc cacccucucc     1080

cucgccuccu cccaggccuc cggccccgcc cucucccgcc accuccucac cuccuucguc     1140

uccggccucu ccgacggcau ggacuccggc uacgucgagg acuccgagga guccuccucc     1200

gaguggcccu ggcgccgcgg cucccaggag cgccgcggcc accgccgccc cggccagaag     1260

uucauccgca ucuacaagcu cuucaagucc accucccagc ucguccuccg ccgcgacucc     1320

cgcucccucg agggcuccuc cgacaccgcc cucccccucc gccgcgccgg cucccucugc     1380

uccccccucg acgagcccgu cucccccccc ucccgcgccc agcgcucccg cucccucccc     1440

cagcccaagc ucggcaccca gcuccccucc uggcuccucg cccccgccuc ccgcccccag     1500

cgccgccgcc ccuuccucuc cggcgacgag gaccccaagg ccuccacccu ccgcgucguc     1560

gucuucggcu ccgaccgcau cuccggcaag gucgcccgcg ccuacuccaa ccuccgccgc     1620

cucgagaaca accgcccccu ccucacccgc uucuucaagc uccaguucuu cuacgucccc     1680

gucaagcgcu cccacggcac cucccccggc gccugccccc ccccccgcuc ccagaccccc     1740

ucccccccca ccgacucccc ccgccacgcc ucccccggcg agcucggcac cacccccugg     1800

gaggagucca ccaacgacau cucccacuac cucggcaugc ucgaccccug guacgagcgc     1860

aacguccucg gccucaugca ccuccccccc gagguccucu gccagcaguc ccucaaggcc     1920

gaggcccagg cccucgaggg cucccccacc cagcucccca uccucgccga caugcuccuc     1980

uacuacugcc gcuucgccgc ccgccccguc cuccuccagg ucuaccagac cgagcucacc     2040

uucaucaccg gcgagaagac caccgagauc uucauccacu cccucgagcu cggccacucc     2100

gccgccaccc gcgccaucaa ggccuccggc cccggcucca agcgccucgg caucgacggc     2160

gaccgcgagg ccgucccccu cacccuccag aucaucuacu ccaagggcgc caucuccggc     2220

cgcucccgcu gguccaaccu cgagaagguc ugcaccuccg ucaaccucaa caaggccugc     2280

cgcaagcagg aggagcucga cuccuccaug gaggcccuca cccucaaccu caccgagguc     2340

gucaagcgcc agaacuccaa guccaagaag ggcuucaacc agaucuccac cucccagauc     2400

aaggucgaca agguccagau caucggcucc aacuccugcc ccuucgccgu cugccucgac     2460

caggacgagc gcaagauccu ccaguccguc guccgcugcg aggucucccc cugcuacaag     2520

cccgagaagu ccgaccucuc cucccccccc cagacccccc ccgaccuccc cgcccaggcc     2580

gcccccgacc ucugcucccu ccucugccuc cccaucauga ccuucuccgg cgcccucccc     2640

uga                                                                   2643


<210>  9246
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PI3K__Homo_sapiens__ABY87553

<400>  9246
augcagcccg gcgccaccac augcacugag gacagaaucc aacacgcucu ggaaaggugu       60

cuccaugggc uuagccuguc ccggcgcucu acgucaugga gugcaggauu gugcuuaaac      120

uguuggagcc ugcaggagcu agugucccga gauccugguc acuuccucau ucugcuugaa      180

cagauacugc agaagacccg ugagguccaa gaaaaaggca cauacgacuu gcucacucca      240

cuggcccugc ucuuuuauuc uaccguuuua ugcacaccgc auuuuccccc ugauucggac      300

cugcuuuuga aggcggcuuc aaccuaccac agauuucuga cuuggccagu gcccuauugu      360

agcaucugcc aggagcuacu cacauucauu gaugccgagc ugaaagcacc ugggaucagu      420

uaccagaggc uuguacgggc cgaacaggga cugccaauuc gcucccauag aucuagcacc      480

gugacggucu ugcuccugaa ucccguggag guucaagcug aauuuuuagc aguggccaac      540

aagcugucca cuccuggcca cucaccacac agugcuuaua ccacacuccu ucugcaugcc      600

uuccaggcga cuuuuggugc acacugugac gucccggggu ugcauugcag gcuacaggcc      660

aaaacccugg cugagcucga ggauaucuuc acagaaaccg ccgaggcaca ggaacuggcu      720

agcggaauag gcgacgccgc ggaggcccgg cgcuggcuuc gaacgaagcu gcaagcagug      780

ggcgaaaagg cuggguuucc cggaguauug gauacugcca aaccugguaa gcuccacaca      840

aucccaauuc ccguugcuag auguuacacc uauucuuggu cccaggacuc auucgauauc      900

cugcaggaga uuuuacugaa agagcaagaa cuacuccagc cuggcauccu gggggacgau      960

gaggaagagg aagaggagga agaggaagug gaggaagacc uugagacuga cggacacugc     1020

gccgagaggg auagcuugcu gaguacaucu ucccucgcaa gccaugacuc gacccugucu     1080

cuugccuccu cacaggcuag uggcccagcg cugagccggc acuugcucac guccuuuguc     1140

ucuggucuga gcgaugggau ggacucagga uacguggaag auagugagga auccagcucu     1200

gaguggcccu ggcgucgcgg cucacaggag agaaggggcc aucggcgacc ggggcaaaag     1260

uucauacgca uuuacaaauu auuuaagagu accagccagc uggugcuaag aagggacucc     1320

cggucucucg aaggaucgag cgauacagca cugccucuuc gcagagccgg uuccuugugu     1380

ucaccccugg acgagccagu caguccuccc ucuagggcuc agcguagccg gucccuccca     1440

cagcccaagc ugggcacuca auuaccuuca uggcugcuug ccccagcaag ccgaccgcag     1500

agaaggcgcc ccuucuuguc uggggaugaa gacccuaaag ccuccacccu ccggguugug     1560

guauucggaa gugauagaau cagcggcaag guggcuaggg ccuauucuaa ucugcgccga     1620

cuagagaaca aucggccacu gcucacacgu uucuucaaac ugcaguuuuu cuacgucccc     1680

gugaagagau cccacgguac uucaccuggg gcaugcccac ccccgaggag ucagaccccu     1740

agcccaccca cagacucgcc ucgccaugcg ucccccggcg aacuuggaac cacuccaugg     1800

gaggagucua cgaacgacau uagccacuau uugggcaugc uggauccuug guacgaacgg     1860

aauguuuuag ggcucaugca ucugccccca gaggugcuuu gccaacaguc acugaaagcu     1920

gaagcccagg cauuggaggg aaguccgaca cagcucccua uccuggccga caugcuacug     1980

uauuacugua gauuugcugc caggcccguc cuccugcaag uguaucagac cgaacuuacu     2040

uucaucaccg gugagaagac aaccgagauu uuuauacacu ccuuggaacu gggccacucu     2100

gcagcuacuc gagccaucaa agcgagcggg ccaggaucca agcgcuuagg cauugauggu     2160

gaccgggagg ccguaccccu cacacugcag aucauauacu caaagggggc uauuagcggc     2220

agaaguaggu ggucuaaccu ugaaaaaguu ugcacguccg ugaaucugaa caaggcaugu     2280

cguaaacaag aggaacuaga uagcucgaug gaggcccuca cccugaauuu gacugagguc     2340

gugaagcgcc agaacucaaa aucuaagaag ggauucaauc agaucaguac aucccagauc     2400

aaagucgaca aggugcaaau uaucggcagc aacucuugcc cuuuugcugu uugucuggau     2460

caggacgaac ggaaaauuuu acagagcgug guaagaugcg aggucucccc auguuacaag     2520

cccgaaaaau cagaucucag uagcccuccg cagaccccac ccgaccugcc ugcccaagca     2580

gcgccagauc uuugcucucu guugugucuc cccauaauga cauucuccgg ggcccugccu     2640

uga                                                                   2643


<210>  9247
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PI3K__Homo_sapiens__ABY87553

<400>  9247
augcagcccg gcgccaccac cugcaccgag gacagaaucc agcacgcccu ggagagaugc       60

cugcacggcc ugagccugag cagaagaagc accagcugga gcgccggccu gugccugaac      120

ugcuggagcc ugcaggagcu ggugagcaga gaccccggcc acuuccugau ccugcuggag      180

cagauccugc agaagaccag agaggugcag gagaagggca ccuacgaccu gcugaccccc      240

cuggcccugc uguucuacag caccgugcug ugcacccccc acuucccccc cgacagcgac      300

cugcugcuga aggccgccag caccuaccac agauuccuga ccuggcccgu gcccuacugc      360

agcaucugcc aggagcugcu gaccuucauc gacgccgagc ugaaggcccc cggcaucagc      420

uaccagagac uggugagagc cgagcagggc cugcccauca gaagccacag aagcagcacc      480

gugaccgugc ugcugcugaa ccccguggag gugcaggccg aguuccuggc cguggccaac      540

aagcugagca cccccggcca cagcccccac agcgccuaca ccacccugcu gcugcacgcc      600

uuccaggcca ccuucggcgc ccacugcgac gugcccggcc ugcacugcag acugcaggcc      660

aagacccugg ccgagcugga ggacaucuuc accgagaccg ccgaggccca ggagcuggcc      720

agcggcaucg gcgacgccgc cgaggccaga agauggcuga gaaccaagcu gcaggccgug      780

ggcgagaagg ccggcuuccc cggcgugcug gacaccgcca agcccggcaa gcugcacacc      840

auccccaucc ccguggccag augcuacacc uacagcugga gccaggacag cuucgacauc      900

cugcaggaga uccugcugaa ggagcaggag cugcugcagc ccggcauccu gggcgacgac      960

gaggaggagg aggaggagga ggaggaggug gaggaggacc uggagaccga cggccacugc     1020

gccgagagag acagccugcu gagcaccagc agccuggcca gccacgacag cacccugagc     1080

cuggccagca gccaggccag cggccccgcc cugagcagac accugcugac cagcuucgug     1140

agcggccuga gcgacggcau ggacagcggc uacguggagg acagcgagga gagcagcagc     1200

gaguggcccu ggagaagagg cagccaggag agaagaggcc acagaagacc cggccagaag     1260

uucaucagaa ucuacaagcu guucaagagc accagccagc uggugcugag aagagacagc     1320

agaagccugg agggcagcag cgacaccgcc cugccccuga gaagagccgg cagccugugc     1380

agcccccugg acgagcccgu gagccccccc agcagagccc agagaagcag aagccugccc     1440

cagcccaagc ugggcaccca gcugcccagc uggcugcugg cccccgccag cagaccccag     1500

agaagaagac ccuuccugag cggcgacgag gaccccaagg ccagcacccu gagaguggug     1560

guguucggca gcgacagaau cagcggcaag guggccagag ccuacagcaa ccugagaaga     1620

cuggagaaca acagaccccu gcugaccaga uucuucaagc ugcaguucuu cuacgugccc     1680

gugaagagaa gccacggcac cagccccggc gccugccccc cccccagaag ccagaccccc     1740

agccccccca ccgacagccc cagacacgcc agccccggcg agcugggcac cacccccugg     1800

gaggagagca ccaacgacau cagccacuac cugggcaugc uggaccccug guacgagaga     1860

aacgugcugg gccugaugca ccugcccccc gaggugcugu gccagcagag ccugaaggcc     1920

gaggcccagg cccuggaggg cagccccacc cagcugccca uccuggccga caugcugcug     1980

uacuacugca gauucgccgc cagacccgug cugcugcagg uguaccagac cgagcugacc     2040

uucaucaccg gcgagaagac caccgagauc uucauccaca gccuggagcu gggccacagc     2100

gccgccacca gagccaucaa ggccagcggc cccggcagca agagacuggg caucgacggc     2160

gacagagagg ccgugccccu gacccugcag aucaucuaca gcaagggcgc caucagcggc     2220

agaagcagau ggagcaaccu ggagaaggug ugcaccagcg ugaaccugaa caaggccugc     2280

agaaagcagg aggagcugga cagcagcaug gaggcccuga cccugaaccu gaccgaggug     2340

gugaagagac agaacagcaa gagcaagaag ggcuucaacc agaucagcac cagccagauc     2400

aagguggaca aggugcagau caucggcagc aacagcugcc ccuucgccgu gugccuggac     2460

caggacgaga gaaagauccu gcagagcgug gugagaugcg aggugagccc cugcuacaag     2520

cccgagaaga gcgaccugag cagccccccc cagacccccc ccgaccugcc cgcccaggcc     2580

gcccccgacc ugugcagccu gcugugccug cccaucauga ccuucagcgg cgcccugccc     2640

uga                                                                   2643


<210>  9248
<211>  2643
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PI3K__Homo_sapiens__ABY87553

<400>  9248
augcagcccg gcgccaccac augcacggag gacagaaucc aacacgcucu ggaacggugu       60

cuccaugggc ugagccuuuc ccgcagaucu accagcuggu ccgccggacu gugccucaac      120

uguuggucuc ugcaggagcu ugugagccgg gauccuggcc acuuccugau ucuccuggaa      180

cagauccugc agaagacacg cgagguccaa gaaaaaggga ccuacgaccu ccugacaccg      240

cuugcgcugc ucuuuuauuc caccguucug ugcacacccc auuucccucc cgauucugac      300

cuucugcuca aggcugccag caccuaccac agauuucuga cguggccugu gcccuauugu      360

uccauuugcc aggagcugcu caccuucauc gaugccgagc ugaaagcucc uggaauuagc      420

uaccagcggc uugugcgcgc cgaacagggc cugccgauca gaucucaucg guccagcaca      480

gucaccgugc uccugcuuaa ucccguugag gugcaagcug aauuucuggc cgucgcgaac      540

aagcucucua caccugggca cagcccccac agcgccuaua ccacgcugcu gcuccaugcu      600

uuccaggcca cauuuggagc ucacugugac gugccuggcc ugcauugccg ccuucaggcc      660

aaaacccugg cggagcucga ggauaucuuc acagaaaccg ccgaggcuca ggaacuggcc      720

ucuggcauug gggacgcugc cgaggccaga cgguggcuuc gcaccaagcu gcaagcuguu      780

ggagaaaagg cgggcuuucc cggggugcuc gauacagcca aaccgggaaa gcugcacacg      840

aucccuauuc ccgucgcuag auguuacacc uauuccugga gccaggacuc cuucgauauc      900

cugcaggaga uucuccugaa agagcaagaa cuucugcagc cuggcauccu cggggacgau      960

gaggaagagg aagaggagga agaggaagug gaggaagacc uggagacaga cggacacugc     1020

gccgagcggg auucucugcu uagcaccucc agccucgccu cucaugacuc cacacugagc     1080

cuggcuucua gccaggccuc cggccccgcg cucucucgcc aucugcuuac cagcuuugug     1140

uccggccuga gcgaugggau ggacucugga uacgucgaag auuccgagga auccucuucc     1200

gaguggcccu ggagacgggg cagccaggag agacgcgggc accggagacc uggacaaaag     1260

uucauucgca ucuacaaacu cuuuaagucc acgucucagc ugguucugcg gagagacagc     1320

cgcucccuug aaggcucuag cgauacagcu cucccgcugc ggagagccgg gucccugugu     1380

agcccccucg acgagccugu gucucccccu ucccgcgccc agcggagcag aucucugccc     1440

cagccgaaac uuggaaccca acugccuucc uggcuccugg cucccgccag ccgcccucag     1500

cggagacggc ccuuccuguc uggcgaugaa gacccuaagg cuagcacccu ucgcgugguc     1560

guguucggcu ccgauagaau cagcgggaag guugcccggg cguauucuaa ucucagacgc     1620

cuggagaaca aucggccccu gcucacaaga uuuuucaaac ugcaguuuuu cuacgugccg     1680

gucaagcgcu cccacggaac cagcccuggc gccugcccuc cgcccagauc ccagacaccc     1740

ucucccccua cggacagccc ccggcaugcu uccccugggg aacuuggaac cacacccugg     1800

gaggagucua ccaacgacau uagccacuau cugggcaugc ucgauccuug guacgaacgc     1860

aaugugcugg ggcugaugca ccuucccccg gagguucucu gccaacaguc ccugaaagcc     1920

gaagcucagg cccuggaggg cucuccuaca cagcucccca uccuggcgga caugcuucug     1980

uauuacugua gauuugccgc ucggccugug cuccugcaag ucuaucagac cgaacugacg     2040

uucauuaccg gagagaagac aaccgagauc uuuauucaua gccuugaacu gggccacucc     2100

gccgcuacac gcgccaucaa agccagcggg cccggaucua agagacucgg caucgauggg     2160

gaccgggagg cugugccgcu gacccuccag auuaucuacu ccaagggagc gauuagcggc     2220

cgcucuagau gguccaaccu ggaaaaaguc ugcacgagcg ugaaucuuaa caaggccugu     2280

cggaaacaag aggaacugga uucuuccaug gaggcucuca cacugaaucu gaccgagguu     2340

gugaagcgcc agaacagcaa auccaagaag ggguucaauc agaucagcac aucucagauu     2400

aaagucgaca aggugcaaau caucggcagc aacuccugcc cuuuugccgu uugucuugau     2460

caggacgaaa gaaaaauucu gcagucugug guccggugcg aggugagccc cuguuacaag     2520

ccugaaaaau ccgaucucuc uagcccuccc cagaccccgc ccgaccugcc cgcccaagcu     2580

gccccugauc ucugcucccu gcuuugucug cccaucauga ccuucucugg agcgcucccu     2640

uga                                                                   2643


<210>  9249
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PKD2__Homo_sapiens__Q13563

<400>  9249

Met Val Asn Ser Ser Arg Val Gln Pro Gln Gln Pro Gly Asp Ala Lys 
1               5                   10                  15      


Arg Pro Pro Ala Pro Arg Ala Pro Asp Pro Gly Arg Leu Met Ala Gly 
            20                  25                  30          


Cys Ala Ala Val Gly Ala Ser Leu Ala Ala Pro Gly Gly Leu Cys Glu 
        35                  40                  45              


Gln Arg Gly Leu Glu Ile Glu Met Gln Arg Ile Arg Gln Ala Ala Ala 
    50                  55                  60                  


Arg Asp Pro Pro Ala Gly Ala Ala Ala Ser Pro Ser Pro Pro Leu Ser 
65                  70                  75                  80  


Ser Cys Ser Arg Gln Ala Trp Ser Arg Asp Asn Pro Gly Phe Glu Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Val Glu Gly Glu Glu Gly Gly Met Val Val 
            100                 105                 110         


Glu Met Asp Val Glu Trp Arg Pro Gly Ser Arg Arg Ser Ala Ala Ser 
        115                 120                 125             


Ser Ala Val Ser Ser Val Gly Ala Arg Ser Arg Gly Leu Gly Gly Tyr 
    130                 135                 140                 


His Gly Ala Gly His Pro Ser Gly Arg Arg Arg Arg Arg Glu Asp Gln 
145                 150                 155                 160 


Gly Pro Pro Cys Pro Ser Pro Val Gly Gly Gly Asp Pro Leu His Arg 
                165                 170                 175     


His Leu Pro Leu Glu Gly Gln Pro Pro Arg Val Ala Trp Ala Glu Arg 
            180                 185                 190         


Leu Val Arg Gly Leu Arg Gly Leu Trp Gly Thr Arg Leu Met Glu Glu 
        195                 200                 205             


Ser Ser Thr Asn Arg Glu Lys Tyr Leu Lys Ser Val Leu Arg Glu Leu 
    210                 215                 220                 


Val Thr Tyr Leu Leu Phe Leu Ile Val Leu Cys Ile Leu Thr Tyr Gly 
225                 230                 235                 240 


Met Met Ser Ser Asn Val Tyr Tyr Tyr Thr Arg Met Met Ser Gln Leu 
                245                 250                 255     


Phe Leu Asp Thr Pro Val Ser Lys Thr Glu Lys Thr Asn Phe Lys Thr 
            260                 265                 270         


Leu Ser Ser Met Glu Asp Phe Trp Lys Phe Thr Glu Gly Ser Leu Leu 
        275                 280                 285             


Asp Gly Leu Tyr Trp Lys Met Gln Pro Ser Asn Gln Thr Glu Ala Asp 
    290                 295                 300                 


Asn Arg Ser Phe Ile Phe Tyr Glu Asn Leu Leu Leu Gly Val Pro Arg 
305                 310                 315                 320 


Ile Arg Gln Leu Arg Val Arg Asn Gly Ser Cys Ser Ile Pro Gln Asp 
                325                 330                 335     


Leu Arg Asp Glu Ile Lys Glu Cys Tyr Asp Val Tyr Ser Val Ser Ser 
            340                 345                 350         


Glu Asp Arg Ala Pro Phe Gly Pro Arg Asn Gly Thr Ala Trp Ile Tyr 
        355                 360                 365             


Thr Ser Glu Lys Asp Leu Asn Gly Ser Ser His Trp Gly Ile Ile Ala 
    370                 375                 380                 


Thr Tyr Ser Gly Ala Gly Tyr Tyr Leu Asp Leu Ser Arg Thr Arg Glu 
385                 390                 395                 400 


Glu Thr Ala Ala Gln Val Ala Ser Leu Lys Lys Asn Val Trp Leu Asp 
                405                 410                 415     


Arg Gly Thr Arg Ala Thr Phe Ile Asp Phe Ser Val Tyr Asn Ala Asn 
            420                 425                 430         


Ile Asn Leu Phe Cys Val Val Arg Leu Leu Val Glu Phe Pro Ala Thr 
        435                 440                 445             


Gly Gly Val Ile Pro Ser Trp Gln Phe Gln Pro Leu Lys Leu Ile Arg 
    450                 455                 460                 


Tyr Val Thr Thr Phe Asp Phe Phe Leu Ala Ala Cys Glu Ile Ile Phe 
465                 470                 475                 480 


Cys Phe Phe Ile Phe Tyr Tyr Val Val Glu Glu Ile Leu Glu Ile Arg 
                485                 490                 495     


Ile His Lys Leu His Tyr Phe Arg Ser Phe Trp Asn Cys Leu Asp Val 
            500                 505                 510         


Val Ile Val Val Leu Ser Val Val Ala Ile Gly Ile Asn Ile Tyr Arg 
        515                 520                 525             


Thr Ser Asn Val Glu Val Leu Leu Gln Phe Leu Glu Asp Gln Asn Thr 
    530                 535                 540                 


Phe Pro Asn Phe Glu His Leu Ala Tyr Trp Gln Ile Gln Phe Asn Asn 
545                 550                 555                 560 


Ile Ala Ala Val Thr Val Phe Phe Val Trp Ile Lys Leu Phe Lys Phe 
                565                 570                 575     


Ile Asn Phe Asn Arg Thr Met Ser Gln Leu Ser Thr Thr Met Ser Arg 
            580                 585                 590         


Cys Ala Lys Asp Leu Phe Gly Phe Ala Ile Met Phe Phe Ile Ile Phe 
        595                 600                 605             


Leu Ala Tyr Ala Gln Leu Ala Tyr Leu Val Phe Gly Thr Gln Val Asp 
    610                 615                 620                 


Asp Phe Ser Thr Phe Gln Glu Cys Ile Phe Thr Gln Phe Arg Ile Ile 
625                 630                 635                 640 


Leu Gly Asp Ile Asn Phe Ala Glu Ile Glu Glu Ala Asn Arg Val Leu 
                645                 650                 655     


Gly Pro Ile Tyr Phe Thr Thr Phe Val Phe Phe Met Phe Phe Ile Leu 
            660                 665                 670         


Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser Glu Val Lys 
        675                 680                 685             


Ser Asp Leu Ala Gln Gln Lys Ala Glu Met Glu Leu Ser Asp Leu Ile 
    690                 695                 700                 


Arg Lys Gly Tyr His Lys Ala Leu Val Lys Leu Lys Leu Lys Lys Asn 
705                 710                 715                 720 


Thr Val Asp Asp Ile Ser Glu Ser Leu Arg Gln Gly Gly Gly Lys Leu 
                725                 730                 735     


Asn Phe Asp Glu Leu Arg Gln Asp Leu Lys Gly Lys Gly His Thr Asp 
            740                 745                 750         


Ala Glu Ile Glu Ala Ile Phe Thr Lys Tyr Asp Gln Asp Gly Asp Gln 
        755                 760                 765             


Glu Leu Thr Glu His Glu His Gln Gln Met Arg Asp Asp Leu Glu Lys 
    770                 775                 780                 


Glu Arg Glu Asp Leu Asp Leu Asp His Ser Ser Leu Pro Arg Pro Met 
785                 790                 795                 800 


Ser Ser Arg Ser Phe Pro Arg Ser Leu Asp Asp Ser Glu Glu Asp Asp 
                805                 810                 815     


Asp Glu Asp Ser Gly His Ser Ser Arg Arg Arg Gly Ser Ile Ser Ser 
            820                 825                 830         


Gly Val Ser Tyr Glu Glu Phe Gln Val Leu Val Arg Arg Val Asp Arg 
        835                 840                 845             


Met Glu His Ser Ile Gly Ser Ile Val Ser Lys Ile Asp Ala Val Ile 
    850                 855                 860                 


Val Lys Leu Glu Ile Met Glu Arg Ala Lys Leu Lys Arg Arg Glu Val 
865                 870                 875                 880 


Leu Gly Arg Leu Leu Asp Gly Val Ala Glu Asp Glu Arg Leu Gly Arg 
                885                 890                 895     


Asp Ser Glu Ile His Arg Glu Gln Met Glu Arg Leu Val Arg Glu Glu 
            900                 905                 910         


Leu Glu Arg Trp Glu Ser Asp Asp Ala Ala Ser Gln Ile Ser His Gly 
        915                 920                 925             


Leu Gly Thr Pro Val Gly Leu Asn Gly Gln Pro Arg Pro Arg Ser Ser 
    930                 935                 940                 


Arg Pro Ser Ser Ser Gln Ser Thr Glu Gly Met Glu Gly Ala Gly Gly 
945                 950                 955                 960 


Asn Gly Ser Ser Asn Val His Val 
                965             


<210>  9250
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PKD2__Homo_sapiens__AAC50520

<400>  9250
auggugaacu ccagucgcgu gcagccucag cagcccgggg acgccaagcg gccgcccgcg       60

ccccgcgcgc cggacccggg ccggcugaug gcuggcugcg cggccguggg cgccagccuc      120

gccgccccgg gcggccucug cgagcagcgg ggccuggaga ucgagaugca gcgcauccgg      180

caggcggccg cgcgggaccc cccggccgga gccgcggccu ccccuucucc uccgcucucg      240

ucgugcuccc ggcaggcgug gagccgcgau aaccccggcu ucgaggccga ggaggaggag      300

gaggaggugg aaggggaaga aggcggaaug gugguggaga uggacguaga guggcgcccg      360

ggcagccgga ggucggccgc cuccucggcc gugagcuccg ugggcgcgcg gagccggggg      420

cuugggggcu accacggcgc gggccacccg agcgggaggc ggcgccggcg agaggaccag      480

ggcccgccgu gccccagccc agucggcggc ggggacccgc ugcaucgcca ccucccccug      540

gaagggcagc cgccccgagu ggccugggcg gagaggcugg uucgcgggcu gcgaggucuc      600

uggggaacaa gacucaugga ggaaagcagc acuaaccgag agaaauaccu uaaaaguguu      660

uuacgggaac uggucacaua ccuccuuuuu cucauagucu ugugcaucuu gaccuacggc      720

augaugagcu ccaaugugua cuacuacacc cggaugaugu cacagcucuu ccuagacacc      780

cccgugucca aaacggagaa aacuaacuuu aaaacucugu cuuccaugga agacuucugg      840

aaguucacag aaggcuccuu auuggauggg cuguacugga agaugcagcc cagcaaccag      900

acugaagcug acaaccgaag uuucaucuuc uaugagaacc ugcuguuagg gguuccacga      960

auacggcaac uccgagucag aaauggaucc ugcucuaucc cccaggacuu gagagaugaa     1020

auuaaagagu gcuaugaugu cuacucuguc aguagugaag auagggcucc cuuugggccc     1080

cgaaauggaa ccgcuuggau cuacacaagu gaaaaagacu ugaaugguag uagccacugg     1140

ggaaucauug caacuuauag uggagcuggc uauuaucugg auuugucaag aacaagagag     1200

gaaacagcug cacaaguugc uagccucaag aaaaaugucu ggcuggaccg aggaaccagg     1260

gcaacuuuua uugacuucuc aguguacaac gccaacauua accuguucug uguggucagg     1320

uuauugguug aauucccagc aacagguggu gugauuccau cuuggcaauu ucagccuuua     1380

aagcugaucc gauaugucac aacuuuugau uucuuccugg cagccuguga gauuaucuuu     1440

uguuucuuua ucuuuuacua ugugguggaa gagauauugg aaauucgcau ucacaaacua     1500

cacuauuuca ggaguuucug gaauugucug gauguuguga ucguugugcu gucaguggua     1560

gcuauaggaa uuaacauaua cagaacauca aauguggagg ugcuacuaca guuucuggaa     1620

gaucaaaaua cuuuccccaa cuuugagcau cuggcauauu ggcagauaca guucaacaau     1680

auagcugcug ucacaguauu uuuugucugg auuaagcucu ucaaauucau caauuuuaac     1740

aggaccauga gccagcucuc gacaaccaug ucucgaugug ccaaagaccu guuuggcuuu     1800

gcuauuaugu ucuucauuau uuuccuagcg uaugcucagu uggcauaccu ugucuuuggc     1860

acucaggucg augacuucag uacuuuccaa gaguguaucu ucacucaauu ccguaucauu     1920

uugggcgaua ucaacuuugc agagauugag gaagcuaauc gaguuuuggg accaauuuau     1980

uucacuacau uuguguucuu uauguucuuc auucuuuuga auauguuuuu ggcuaucauc     2040

aaugauacuu acucugaagu gaaaucugac uuggcacagc agaaagcuga aauggaacuc     2100

ucagaucuua ucagaaaggg cuaccauaaa gcuuugguca aacuaaaacu gaaaaaaaau     2160

accguggaug acauuucaga gagucugcgg caaggaggag gcaaguuaaa cuuugacgaa     2220

cuucgacaag aucucaaagg gaagggccau acugaugcag agauugaggc aauauucaca     2280

aaguacgacc aagauggaga ccaagaacug accgaacaug aacaucagca gaugagagac     2340

gacuuggaga aagagaggga ggaccuggau uuggaucaca guucuuuacc acgucccaug     2400

agcagccgaa guuucccucg aagccuggau gacucugagg aggaugacga ugaagauagc     2460

ggacauagcu ccagaaggag gggaagcauu ucuaguggcg uuucuuacga agaguuucaa     2520

guccugguga gacgagugga ccggauggag cauuccaucg gcagcauagu guccaagauu     2580

gacgccguga ucgugaagcu agagauuaug gagcgagcca aacugaagag gagggaggug     2640

cugggaaggc uguuggaugg gguggccgag gaugaaaggc ugggucguga cagugaaauc     2700

cauagggaac agauggaacg gcuaguacgu gaagaguugg aacgcuggga auccgaugau     2760

gcagcuuccc agaucaguca ugguuuaggc acgccagugg gacuaaaugg ucaaccucgc     2820

cccagaagcu cccgcccauc uuccucccaa ucuacagaag gcauggaagg ugcaggugga     2880

aaugggaguu cuaaugucca cguauga                                         2907


<210>  9251
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PKD2__Homo_sapiens__AAC50520

<400>  9251
auggugaaca gcucccgcgu ccagccccag cagccgggcg acgccaagcg gccgcccgcg       60

ccccgcgcgc ccgaccccgg gcggcugaug gccggcugcg ccgccguggg ggccagccuc      120

gcggcccccg gcgggcugug cgagcagcgc ggccuggaga ucgagaugca gcggauccgc      180

caggccgccg cgcgggaccc gcccgccggc gccgccgccu cccccagccc gccccugucc      240

agcugcuccc gccaggcgug gagccgggac aaccccgggu ucgaggccga ggaggaggag      300

gaggaggugg agggcgagga gggcgggaug gucguggaga uggacgugga guggcgcccc      360

gggucccggc gcagcgccgc cuccagcgcc gucuccagcg ugggcgcgcg gucccgcggc      420

cucgggggcu accacggggc cggccacccc agcggccggc gccggcgccg ggaggaccag      480

gggcccccgu gccccucccc cgugggcggg ggcgaccccc ugcaccgcca ccucccgcug      540

gaggggcagc cgccccgggu cgccugggcc gagcgccugg ugcgcggccu ccggggccug      600

ugggggaccc gccugaugga ggagagcucc accaaccggg agaaguaccu caagagcgug      660

cugcgcgagc uggucacgua ccuccuguuc cugaucgugc ucugcauccu gaccuacggc      720

augaugagcu ccaacgugua cuacuacacc cggaugauga gccagcuguu ccucgacacc      780

cccgucucca agacggagaa gaccaacuuc aagacccuga gcuccaugga ggacuucugg      840

aaguucaccg aggggagccu gcucgacggc cuguacugga agaugcagcc cuccaaccag      900

acggaggccg acaaccgcag cuucaucuuc uacgagaacc ugcuccuggg ggugccccgg      960

auccgccagc ugcgggugcg caacggcucc ugcagcaucc cccaggaccu ccgggacgag     1020

aucaaggagu gcuacgacgu cuacuccgug agcuccgagg accgcgcgcc cuucggcccg     1080

cggaacggga ccgccuggau cuacaccagc gagaaggacc ugaacggcuc cagccacugg     1140

gggaucaucg ccaccuacuc cggcgccggg uacuaccugg accucagccg cacgcgggag     1200

gagaccgccg cccagguggc cucccugaag aagaacgucu ggcuggaccg cggcacccgg     1260

gccaccuuca ucgacuucag cguguacaac gccaacauca accucuucug cgugguccgc     1320

cugcuggugg aguuccccgc gacgggcggg gucaucccca gcuggcaguu ccagccgcuc     1380

aagcugaucc gguacgugac caccuucgac uucuuccugg ccgccugcga gaucaucuuc     1440

ugcuucuuca ucuucuacua cguggucgag gagauccucg agauccgcau ccacaagcug     1500

cacuacuucc gcuccuucug gaacugccug gacgugguga ucgucgugcu cagcgugguc     1560

gccaucggca ucaacaucua ccggaccucc aacguggagg ugcugcugca guuccucgag     1620

gaccagaaca cguuccccaa cuucgagcac cuggccuacu ggcagaucca guucaacaac     1680

aucgcggccg ucaccguguu cuucgugugg aucaagcugu ucaaguucau caacuucaac     1740

cgcaccauga gccagcuguc caccacgaug agccggugcg ccaaggaccu cuucggguuc     1800

gccaucaugu ucuucaucau cuuccuggcc uacgcgcagc uggccuaccu cgucuucggc     1860

acccaggugg acgacuucuc caccuuccag gagugcaucu ucacccaguu ccgcaucauc     1920

cugggcgaca ucaacuucgc cgagaucgag gaggccaacc gggugcuggg gcccaucuac     1980

uucacgaccu ucgucuucuu cauguucuuc auccuccuga acauguuccu ggccaucauc     2040

aacgacaccu acagcgaggu gaaguccgac cucgcgcagc agaaggccga gauggagcug     2100

agcgaccuga uccgcaaggg cuaccacaag gcccucguga agcugaagcu gaagaagaac     2160

accgucgacg acaucuccga gagccuccgg cagggcggcg ggaagcugaa cuucgacgag     2220

cugcgccagg accucaaggg gaagggccac acggacgccg agaucgaggc gaucuucacc     2280

aaguacgacc aggacgggga ccaggagcug accgagcacg agcaccagca gaugcgggac     2340

gaccuggaga aggagcgcga ggaccucgac cuggaccacu ccagccugcc ccggccgaug     2400

uccagccgcu ccuucccccg gagccucgac gacagcgagg aggacgacga cgaggacucc     2460

ggccacagcu cccgccggcg cgggagcauc uccagcggcg uguccuacga ggaguuccag     2520

gugcuggucc ggcgcgugga ccggauggag cacagcaucg gguccaucgu gagcaagauc     2580

gacgccguca ucgugaagcu ggagaucaug gagcgcgcca agcucaagcg gcgcgaggug     2640

cugggccgcc ugcucgacgg cgucgccgag gacgagcggc uggggcgcga cuccgagauc     2700

caccgggagc agauggagcg ccuggugcgg gaggagcucg agcgcuggga gagcgacgac     2760

gccgcguccc agaucagcca cggccugggg acccccgugg gccugaacgg gcagccccgg     2820

ccgcgcucca gccggcccuc cagcucccag agcacggagg gcauggaggg cgccgggggc     2880

aacgggagcu ccaacgucca cguguga                                         2907


<210>  9252
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PKD2__Homo_sapiens__AAC50520

<400>  9252
auggucaacu ccucccgcgu ccagccccag cagcccggcg acgccaagcg cccccccgcc       60

ccccgcgccc ccgaccccgg ccgccucaug gccggcugcg ccgccgucgg cgccucccuc      120

gccgcccccg gcggccucug cgagcagcgc ggccucgaga ucgagaugca gcgcauccgc      180

caggccgccg cccgcgaccc ccccgccggc gccgccgccu cccccucccc cccccucucc      240

uccugcuccc gccaggccug gucccgcgac aaccccggcu ucgaggccga ggaggaggag      300

gaggaggucg agggcgagga gggcggcaug gucgucgaga uggacgucga guggcgcccc      360

ggcucccgcc gcuccgccgc cuccuccgcc gucuccuccg ucggcgcccg cucccgcggc      420

cucggcggcu accacggcgc cggccacccc uccggccgcc gccgccgccg cgaggaccag      480

ggcccccccu gccccucccc cgucggcggc ggcgaccccc uccaccgcca ccucccccuc      540

gagggccagc ccccccgcgu cgccugggcc gagcgccucg uccgcggccu ccgcggccuc      600

uggggcaccc gccucaugga ggaguccucc accaaccgcg agaaguaccu caaguccguc      660

cuccgcgagc ucgucaccua ccuccucuuc cucaucgucc ucugcauccu caccuacggc      720

augauguccu ccaacgucua cuacuacacc cgcaugaugu cccagcucuu ccucgacacc      780

cccgucucca agaccgagaa gaccaacuuc aagacccucu ccuccaugga ggacuucugg      840

aaguucaccg agggcucccu ccucgacggc cucuacugga agaugcagcc cuccaaccag      900

accgaggccg acaaccgcuc cuucaucuuc uacgagaacc uccuccucgg cgucccccgc      960

auccgccagc uccgcguccg caacggcucc ugcuccaucc cccaggaccu ccgcgacgag     1020

aucaaggagu gcuacgacgu cuacuccguc uccuccgagg accgcgcccc cuucggcccc     1080

cgcaacggca ccgccuggau cuacaccucc gagaaggacc ucaacggcuc cucccacugg     1140

ggcaucaucg ccaccuacuc cggcgccggc uacuaccucg accucucccg cacccgcgag     1200

gagaccgccg cccaggucgc cucccucaag aagaacgucu ggcucgaccg cggcacccgc     1260

gccaccuuca ucgacuucuc cgucuacaac gccaacauca accucuucug cgucguccgc     1320

cuccucgucg aguuccccgc caccggcggc gucauccccu ccuggcaguu ccagccccuc     1380

aagcucaucc gcuacgucac caccuucgac uucuuccucg ccgccugcga gaucaucuuc     1440

ugcuucuuca ucuucuacua cgucgucgag gagauccucg agauccgcau ccacaagcuc     1500

cacuacuucc gcuccuucug gaacugccuc gacgucguca ucgucguccu cuccgucguc     1560

gccaucggca ucaacaucua ccgcaccucc aacgucgagg uccuccucca guuccucgag     1620

gaccagaaca ccuuccccaa cuucgagcac cucgccuacu ggcagaucca guucaacaac     1680

aucgccgccg ucaccgucuu cuucgucugg aucaagcucu ucaaguucau caacuucaac     1740

cgcaccaugu cccagcucuc caccaccaug ucccgcugcg ccaaggaccu cuucggcuuc     1800

gccaucaugu ucuucaucau cuuccucgcc uacgcccagc ucgccuaccu cgucuucggc     1860

acccaggucg acgacuucuc caccuuccag gagugcaucu ucacccaguu ccgcaucauc     1920

cucggcgaca ucaacuucgc cgagaucgag gaggccaacc gcguccucgg ccccaucuac     1980

uucaccaccu ucgucuucuu cauguucuuc auccuccuca acauguuccu cgccaucauc     2040

aacgacaccu acuccgaggu caaguccgac cucgcccagc agaaggccga gauggagcuc     2100

uccgaccuca uccgcaaggg cuaccacaag gcccucguca agcucaagcu caagaagaac     2160

accgucgacg acaucuccga gucccuccgc cagggcggcg gcaagcucaa cuucgacgag     2220

cuccgccagg accucaaggg caagggccac accgacgccg agaucgaggc caucuucacc     2280

aaguacgacc aggacggcga ccaggagcuc accgagcacg agcaccagca gaugcgcgac     2340

gaccucgaga aggagcgcga ggaccucgac cucgaccacu ccucccuccc ccgccccaug     2400

uccucccgcu ccuucccccg cucccucgac gacuccgagg aggacgacga cgaggacucc     2460

ggccacuccu cccgccgccg cggcuccauc uccuccggcg ucuccuacga ggaguuccag     2520

guccucgucc gccgcgucga ccgcauggag cacuccaucg gcuccaucgu cuccaagauc     2580

gacgccguca ucgucaagcu cgagaucaug gagcgcgcca agcucaagcg ccgcgagguc     2640

cucggccgcc uccucgacgg cgucgccgag gacgagcgcc ucggccgcga cuccgagauc     2700

caccgcgagc agauggagcg ccucguccgc gaggagcucg agcgcuggga guccgacgac     2760

gccgccuccc agaucuccca cggccucggc acccccgucg gccucaacgg ccagccccgc     2820

ccccgcuccu cccgccccuc cuccucccag uccaccgagg gcauggaggg cgccggcggc     2880

aacggcuccu ccaacgucca cgucuga                                         2907


<210>  9253
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PKD2__Homo_sapiens__AAC50520

<400>  9253
auggugaaca gcuccagagu ccagccccaa cagccuggcg acgccaagag gccaccggcu       60

ccccgggcac cugauccagg gcgccugaug gccggaugcg cggcuguugg ugccucucuc      120

gcagcccccg gcgggcuuug ugagcagcga ggacuggaaa ucgagaugca gcguauuaga      180

caagcugcag ccagggaccc uccagcuggc gccgcggcau cacccagucc uccauugagc      240

uccugcucuc ggcaggccug gucgcgcgau aauccggguu ucgaagcuga ggaagaggag      300

gaagaggugg aaggggagga gggaggcaug guaguggaaa uggacgucga guggagaccc      360

ggcucaaggc ggagcgccgc aaguuccgcu gugucuagcg uuggggcccg cucccgagga      420

uuagguggcu accacggggc gggacauccu ucaggcagaa ggcggcgucg cgaagaucag      480

gguccacccu guccuagucc agucggggga ggcgaccccc ugcacagaca ucuaccgcuc      540

gagggccagc cucccagggu ggccugggca gaacggcugg ugcgagggcu ucgcggacug      600

ugggguacca gauugaugga ggagagcucu acaaacaggg aaaaauaucu caaguccgua      660

cugcgggagc ugguuacuua ccucuuauuu cugauagugc uuugcaucuu gacguauggc      720

augaugucaa gcaaugucua cuauuacacc cgcaugauga gucaacuguu ccuagauaca      780

ccagugucua aaacugaaaa gaccaacuuu aaaacacucu ccagcaugga ggacuucugg      840

aaguuuaccg aagggucgcu gcuugaugga cuguauugga agaugcagcc uucuaaucag      900

acugaggcug acaacagauc cuucauuuuc uacgagaauu ugcuccuggg cgugcccagg      960

auccgucagu uacggguccg aaacgguuca uguaguauuc cacaagaucu gagagacgaa     1020

aucaaagagu gcuacgaugu uuauagcgug uccucugaag acagggcccc cuucgggccu     1080

cgcaauggca cagcuuggau auacaccagc gagaaggacc ucaacggauc aagucacugg     1140

ggcaucauug ccacguauuc cggggcagga uacuaucuug aucugagccg gacuagagaa     1200

gagaccgccg cucagguagc gucuuugaaa aagaaugugu ggcuagacag ggguacacgc     1260

gcaacuuuua ucgauuucuc agucuacaac gccaauauua accuguuuug ugugguucga     1320

cuccuggugg aguucccagc uaccggcggg gucaucccga guuggcaguu ucaaccccuu     1380

aaacugauac gguaugugac aaccuucgac uucuuuuugg ccgcaugcga aauuaucuuc     1440

ugcuuuuuca ucuuuuacua cguaguugag gaaauucucg agauccguau ucauaagcug     1500

cacuauuuca ggagcuuuug gaauuguuua gaugugguca uagugguccu guccgugguu     1560

gccaucggaa uuaacaucua cagaacgucu aacguggagg uacuacucca guuccuggaa     1620

gaccagaaua cuuuuccuaa cuucgagcac cuugcuuauu ggcagauaca auuuaauaac     1680

auugccgcag ucacaguguu cuuuguuugg aucaaguugu ucaaauucau caauuuuaac     1740

cgcaccaugu cgcagcugag cacuacaaug ucccggugug cgaaggaucu cuucggcuuu     1800

gcuauuaugu ucuuuaucau uuuccuggcc uacgcacagc uugccuaucu gguguuuggu     1860

acccaggucg acgauuucuc aacguuucaa gaaugcauau ucacccaguu uagaaucauu     1920

uugggggaca ucaauuucgc ugagaucgaa gaggccaaca gggugcucgg cccaauuuac     1980

uuuacaacuu ucguauucuu uauguucuuu auacuguuaa auauguuccu ggcaaucauu     2040

aacgauaccu auagugaggu gaaaucugac cuagcucagc agaaggccga aauggagcuc     2100

agcgaccuga uccgaaaagg auaccauaag gcgcuuguua aauugaagcu gaagaaaaau     2160

acagucgaug acauuuccga aucacuccgc caaggcgggg gaaagcugaa cuuugaugag     2220

uuacggcagg accugaaagg uaagggccac acugaugccg aaaucgaggc uauauucacc     2280

aaauacgacc aggaugggga ccaggagcuu acagaacaug agcaccaaca gaugagagau     2340

gacuuggaaa aggagaggga agaucucgac cuggaucaca gcucucuacc ccguccuaug     2400

uccagucgca gcuuuccacg gucucuggac gacuccgagg aggaugacga ugaagacuca     2460

ggacauagua gcagaaggcg aggcucgauc uccucuggug ugagcuauga ggaauuucag     2520

gugcucgucc ggcgcguuga uagaauggag cacucaauug ggaguaucgu guccaagauu     2580

gacgcaguga ucguaaaacu ggagauaaug gaaagggcca aacuuaagcg gcgagagguc     2640

uugggcagac uguuagaugg aguggcugaa gacgagcgcc ucggcaggga uucugaaauu     2700

caucgugagc aaauggagcg gcugguuaga gaggaacuug aaagguggga gagcgacgau     2760

gccgcauccc agaucucaca cgggcuggga acccccgugg gcuugaaugg ucagccgcgc     2820

ccucgaagca guagaccauc uuccagccag ucgacugaag ggauggaggg agcgggcggu     2880

aacggcucau cuaaugucca uguguga                                         2907


<210>  9254
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PKD2__Homo_sapiens__AAC50520

<400>  9254
auggugaaca gcagcagagu gcagccccag cagcccggcg acgccaagag accccccgcc       60

cccagagccc ccgaccccgg cagacugaug gccggcugcg ccgccguggg cgccagccug      120

gccgcccccg gcggccugug cgagcagaga ggccuggaga ucgagaugca gagaaucaga      180

caggccgccg ccagagaccc ccccgccggc gccgccgcca gccccagccc cccccugagc      240

agcugcagca gacaggccug gagcagagac aaccccggcu ucgaggccga ggaggaggag      300

gaggaggugg agggcgagga gggcggcaug gugguggaga uggacgugga guggagaccc      360

ggcagcagaa gaagcgccgc cagcagcgcc gugagcagcg ugggcgccag aagcagaggc      420

cugggcggcu accacggcgc cggccacccc agcggcagaa gaagaagaag agaggaccag      480

ggcccccccu gccccagccc cgugggcggc ggcgaccccc ugcacagaca ccugccccug      540

gagggccagc cccccagagu ggccugggcc gagagacugg ugagaggccu gagaggccug      600

uggggcacca gacugaugga ggagagcagc accaacagag agaaguaccu gaagagcgug      660

cugagagagc uggugaccua ccugcuguuc cugaucgugc ugugcauccu gaccuacggc      720

augaugagca gcaacgugua cuacuacacc agaaugauga gccagcuguu ccuggacacc      780

cccgugagca agaccgagaa gaccaacuuc aagacccuga gcagcaugga ggacuucugg      840

aaguucaccg agggcagccu gcuggacggc cuguacugga agaugcagcc cagcaaccag      900

accgaggccg acaacagaag cuucaucuuc uacgagaacc ugcugcuggg cgugcccaga      960

aucagacagc ugagagugag aaacggcagc ugcagcaucc cccaggaccu gagagacgag     1020

aucaaggagu gcuacgacgu guacagcgug agcagcgagg acagagcccc cuucggcccc     1080

agaaacggca ccgccuggau cuacaccagc gagaaggacc ugaacggcag cagccacugg     1140

ggcaucaucg ccaccuacag cggcgccggc uacuaccugg accugagcag aaccagagag     1200

gagaccgccg cccagguggc cagccugaag aagaacgugu ggcuggacag aggcaccaga     1260

gccaccuuca ucgacuucag cguguacaac gccaacauca accuguucug cguggugaga     1320

cugcuggugg aguuccccgc caccggcggc gugaucccca gcuggcaguu ccagccccug     1380

aagcugauca gauacgugac caccuucgac uucuuccugg ccgccugcga gaucaucuuc     1440

ugcuucuuca ucuucuacua cgugguggag gagauccugg agaucagaau ccacaagcug     1500

cacuacuuca gaagcuucug gaacugccug gacgugguga ucguggugcu gagcguggug     1560

gccaucggca ucaacaucua cagaaccagc aacguggagg ugcugcugca guuccuggag     1620

gaccagaaca ccuuccccaa cuucgagcac cuggccuacu ggcagaucca guucaacaac     1680

aucgccgccg ugaccguguu cuucgugugg aucaagcugu ucaaguucau caacuucaac     1740

agaaccauga gccagcugag caccaccaug agcagaugcg ccaaggaccu guucggcuuc     1800

gccaucaugu ucuucaucau cuuccuggcc uacgcccagc uggccuaccu gguguucggc     1860

acccaggugg acgacuucag caccuuccag gagugcaucu ucacccaguu cagaaucauc     1920

cugggcgaca ucaacuucgc cgagaucgag gaggccaaca gagugcuggg ccccaucuac     1980

uucaccaccu ucguguucuu cauguucuuc auccugcuga acauguuccu ggccaucauc     2040

aacgacaccu acagcgaggu gaagagcgac cuggcccagc agaaggccga gauggagcug     2100

agcgaccuga ucagaaaggg cuaccacaag gcccugguga agcugaagcu gaagaagaac     2160

accguggacg acaucagcga gagccugaga cagggcggcg gcaagcugaa cuucgacgag     2220

cugagacagg accugaaggg caagggccac accgacgccg agaucgaggc caucuucacc     2280

aaguacgacc aggacggcga ccaggagcug accgagcacg agcaccagca gaugagagac     2340

gaccuggaga aggagagaga ggaccuggac cuggaccaca gcagccugcc cagacccaug     2400

agcagcagaa gcuuccccag aagccuggac gacagcgagg aggacgacga cgaggacagc     2460

ggccacagca gcagaagaag aggcagcauc agcagcggcg ugagcuacga ggaguuccag     2520

gugcugguga gaagagugga cagaauggag cacagcaucg gcagcaucgu gagcaagauc     2580

gacgccguga ucgugaagcu ggagaucaug gagagagcca agcugaagag aagagaggug     2640

cugggcagac ugcuggacgg cguggccgag gacgagagac ugggcagaga cagcgagauc     2700

cacagagagc agauggagag acuggugaga gaggagcugg agagauggga gagcgacgac     2760

gccgccagcc agaucagcca cggccugggc acccccgugg gccugaacgg ccagcccaga     2820

cccagaagca gcagacccag cagcagccag agcaccgagg gcauggaggg cgccggcggc     2880

aacggcagca gcaacgugca cguguga                                         2907


<210>  9255
<211>  2907
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PKD2__Homo_sapiens__AAC50520

<400>  9255
auggugaaca gcuccagagu ccagccccaa cagccuggcg acgccaagcg gccgcccgcu       60

ccucgcgccc ccgauccugg gagacugaug gcgggaugcg cugccguugg cgccucucuc      120

gcugcccccg ggggacugug ugagcagcgg ggccuugaaa ucgagaugca gcgcauuaga      180

caagcugccg cgcgggaccc uccggccggg gcugccgcua gccccucccc uccccugucu      240

agcugcuccc gccaggccug gucuagagau aauccuggau ucgaagcgga ggaagaggag      300

gaagaggugg aaggcgagga gggcgggaug guggucgaaa uggacgugga guggcggccc      360

ggaagccgca gauccgccgc uagcucugcc guuuccagcg ugggcgcucg gucucgcggg      420

cucggaggcu accacggggc cggacauccg uccggcagac ggcgcagacg ggaagaucag      480

ggcccucccu guccuagccc cgucggggga ggcgaccccc ugcacagaca ucuuccucug      540

gaggggcagc cgccccgcgu ggccugggcu gaacggcucg uuagaggacu gcgcggccug      600

ugggggaccc ggcucaugga ggagucuucc acaaacagag aaaaauaucu uaagagcgug      660

cuucgcgagc uggucacgua ccuccuguuu cuuaucgugc ugugcauucu caccuaugga      720

augauguccu cuaaugugua cuauuacaca cggaugauga gccaacuguu ccuggauacc      780

ccugucucca aaacagaaaa gaccaacuuu aaaacacuca gcucuaugga ggacuucugg      840

aaguuuaccg aaggcucccu gcuugauggc cuguauugga agaugcagcc cagcaaucag      900

acggaggcgg acaacagauc uuucaucuuu uacgagaauc uccugcuugg gguuccucgc      960

auucggcagc ugagagugcg caacggaagc uguuccaucc cccaagaucu ccgggacgaa     1020

aucaaagagu gcuacgaugu guauucuguc agcuccgaag acagagcccc guucggcccu     1080

cggaauggga ccgcuuggau uuacacaagc gagaaggacc ugaacggauc uucccacugg     1140

ggcaucauug ccaccuauag cggggccggc uacuaucugg aucucucucg cacaagagaa     1200

gagaccgcug cccagguggc gucccugaaa aagaauguuu ggcuugaccg gggaacgaga     1260

gcuacauuua ucgauuucag cguguacaac gccaauauua accuguuuug ugucgugcgc     1320

cuccugguug aguuccccgc caccggcggg gugaucccuu ccuggcaguu ucaaccccuu     1380

aaacugauuc gguaugucac aaccuucgac uucuuucucg cugccugcga aaucaucuuc     1440

uguuucuuca ucuuuuacua cguggucgag gaaauucugg agauuagaau ccauaagcug     1500

cacuauuucc gcucuuuuug gaauugccuc gaugugguua uugugguccu gagcgugguu     1560

gcuaucggaa ucaacauuua cagaaccucc aacguggagg uccuucugca guuccucgaa     1620

gaccagaaua cauuuccuaa cuucgagcac cuggccuauu ggcagaucca auuuaauaac     1680

auugcggccg ugacgguguu cuuuguuugg aucaagcugu ucaaauucau uaauuuuaac     1740

cggaccaugu cucagcuuag cacaaccaug ucccgcugug cuaaggaucu cuucggcuuu     1800

gccaucaugu ucuuuaucau uuuccuggcu uacgcccagc uggcguaucu cgucuuuggg     1860

acacaggugg acgauuucag caccuuucaa gaaugcaucu ucacgcaguu uagaauuauc     1920

cugggagaca uuaauuucgc cgagaucgaa gaggcuaacc gggugcuugg ccccauuuac     1980

uuuacaaccu ucgucuucuu uauguucuuu auccugcuca auauguuccu ggccaucauu     2040

aacgauaccu auucugaggu gaaauccgac cuggcucagc agaaggccga aauggagcuu     2100

agcgaccuca uccgcaaagg guaccauaag gcccugguua aacugaagcu caagaaaaau     2160

acaguggaug acauuucuga aucccugaga caaggcggag gcaagcugaa cuuugaugag     2220

cugcggcagg accucaaagg gaagggacac accgaugcug aaaucgaggc gauuuucaca     2280

aaauacgacc aggauggcga ccaggagcug acggaacaug agcaccaaca gaugcgcgau     2340

gaccuggaaa aggagagaga agaucuugac cucgaucaca gcucucugcc gcggccuaug     2400

agcucccgca gcuuucccag aucucuggac gacuccgagg aggaugacga ugaagacagc     2460

gggcauuccu cucggagacg cggaagcauc uccucuggcg ucagcuauga ggaauuucag     2520

gugcucguuc ggagagugga ucgcauggag cacuccaucg ggucuauugu cagcaagauc     2580

gacgccguga uuguuaaacu ggagaucaug gaacgggcua aacuuaagag acgcgaggug     2640

cugggccggc uccuggaugg agucgccgaa gacgagagac ugggccgcga uuccgaaauu     2700

caucgggagc aaauggagag acuugugcgg gaggaacucg aacgcuggga gagcgacgau     2760

gccgcuucuc agaucuccca cgggcuggga acccccgugg gccugaaugg gcagccuaga     2820

ccgcggagcu cucgccccuc cagcucucag uccacagaag gaauggaggg cgccgggggc     2880

aacggaagcu ccaaugucca uguuuga                                         2907


<210>  9256
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PKN1__Homo_sapiens__Q16512

<400>  9256

Met Ala Ser Asp Ala Val Gln Ser Glu Pro Arg Ser Trp Ser Leu Leu 
1               5                   10                  15      


Glu Gln Leu Gly Leu Ala Gly Ala Asp Leu Ala Ala Pro Gly Val Gln 
            20                  25                  30          


Gln Gln Leu Glu Leu Glu Arg Glu Arg Leu Arg Arg Glu Ile Arg Lys 
        35                  40                  45              


Glu Leu Lys Leu Lys Glu Gly Ala Glu Asn Leu Arg Arg Ala Thr Thr 
    50                  55                  60                  


Asp Leu Gly Arg Ser Leu Gly Pro Val Glu Leu Leu Leu Arg Gly Ser 
65                  70                  75                  80  


Ser Arg Arg Leu Asp Leu Leu His Gln Gln Leu Gln Glu Leu His Ala 
                85                  90                  95      


His Val Val Leu Pro Asp Pro Ala Ala Thr His Asp Gly Pro Gln Ser 
            100                 105                 110         


Pro Gly Ala Gly Gly Pro Thr Cys Ser Ala Thr Asn Leu Ser Arg Val 
        115                 120                 125             


Ala Gly Leu Glu Lys Gln Leu Ala Ile Glu Leu Lys Val Lys Gln Gly 
    130                 135                 140                 


Ala Glu Asn Met Ile Gln Thr Tyr Ser Asn Gly Ser Thr Lys Asp Arg 
145                 150                 155                 160 


Lys Leu Leu Leu Thr Ala Gln Gln Met Leu Gln Asp Ser Lys Thr Lys 
                165                 170                 175     


Ile Asp Ile Ile Arg Met Gln Leu Arg Arg Ala Leu Gln Ala Gly Gln 
            180                 185                 190         


Leu Glu Asn Gln Ala Ala Pro Asp Asp Thr Gln Gly Ser Pro Asp Leu 
        195                 200                 205             


Gly Ala Val Glu Leu Arg Ile Glu Glu Leu Arg His His Phe Arg Val 
    210                 215                 220                 


Glu His Ala Val Ala Glu Gly Ala Lys Asn Val Leu Arg Leu Leu Ser 
225                 230                 235                 240 


Ala Ala Lys Ala Pro Asp Arg Lys Ala Val Ser Glu Ala Gln Glu Lys 
                245                 250                 255     


Leu Thr Glu Ser Asn Gln Lys Leu Gly Leu Leu Arg Glu Ala Leu Glu 
            260                 265                 270         


Arg Arg Leu Gly Glu Leu Pro Ala Asp His Pro Lys Gly Arg Leu Leu 
        275                 280                 285             


Arg Glu Glu Leu Ala Ala Ala Ser Ser Ala Ala Phe Ser Thr Arg Leu 
    290                 295                 300                 


Ala Gly Pro Phe Pro Ala Thr His Tyr Ser Thr Leu Cys Lys Pro Ala 
305                 310                 315                 320 


Pro Leu Thr Gly Thr Leu Glu Val Arg Val Val Gly Cys Arg Asp Leu 
                325                 330                 335     


Pro Glu Thr Ile Pro Trp Asn Pro Thr Pro Ser Met Gly Gly Pro Gly 
            340                 345                 350         


Thr Pro Asp Ser Arg Pro Pro Phe Leu Ser Arg Pro Ala Arg Gly Leu 
        355                 360                 365             


Tyr Ser Arg Ser Gly Ser Leu Ser Gly Arg Ser Ser Leu Lys Ala Glu 
    370                 375                 380                 


Ala Glu Asn Thr Ser Glu Val Ser Thr Val Leu Lys Leu Asp Asn Thr 
385                 390                 395                 400 


Val Val Gly Gln Thr Ser Trp Lys Pro Cys Gly Pro Asn Ala Trp Asp 
                405                 410                 415     


Gln Ser Phe Thr Leu Glu Leu Glu Arg Ala Arg Glu Leu Glu Leu Ala 
            420                 425                 430         


Val Phe Trp Arg Asp Gln Arg Gly Leu Cys Ala Leu Lys Phe Leu Lys 
        435                 440                 445             


Leu Glu Asp Phe Leu Asp Asn Glu Arg His Glu Val Gln Leu Asp Met 
    450                 455                 460                 


Glu Pro Gln Gly Cys Leu Val Ala Glu Val Thr Phe Arg Asn Pro Val 
465                 470                 475                 480 


Ile Glu Arg Ile Pro Arg Leu Arg Arg Gln Lys Lys Ile Phe Ser Lys 
                485                 490                 495     


Gln Gln Gly Lys Ala Phe Gln Arg Ala Arg Gln Met Asn Ile Asp Val 
            500                 505                 510         


Ala Thr Trp Val Arg Leu Leu Arg Arg Leu Ile Pro Asn Ala Thr Gly 
        515                 520                 525             


Thr Gly Thr Phe Ser Pro Gly Ala Ser Pro Gly Ser Glu Ala Arg Thr 
    530                 535                 540                 


Thr Gly Asp Ile Ser Val Glu Lys Leu Asn Leu Gly Thr Asp Ser Asp 
545                 550                 555                 560 


Ser Ser Pro Gln Lys Ser Ser Arg Asp Pro Pro Ser Ser Pro Ser Ser 
                565                 570                 575     


Leu Ser Ser Pro Ile Gln Glu Ser Thr Ala Pro Glu Leu Pro Ser Glu 
            580                 585                 590         


Thr Gln Glu Thr Pro Gly Pro Ala Leu Cys Ser Pro Leu Arg Lys Ser 
        595                 600                 605             


Pro Leu Thr Leu Glu Asp Phe Lys Phe Leu Ala Val Leu Gly Arg Gly 
    610                 615                 620                 


His Phe Gly Lys Val Leu Leu Ser Glu Phe Arg Pro Ser Gly Glu Leu 
625                 630                 635                 640 


Phe Ala Ile Lys Ala Leu Lys Lys Gly Asp Ile Val Ala Arg Asp Glu 
                645                 650                 655     


Val Glu Ser Leu Met Cys Glu Lys Arg Ile Leu Ala Ala Val Thr Ser 
            660                 665                 670         


Ala Gly His Pro Phe Leu Val Asn Leu Phe Gly Cys Phe Gln Thr Pro 
        675                 680                 685             


Glu His Val Cys Phe Val Met Glu Tyr Ser Ala Gly Gly Asp Leu Met 
    690                 695                 700                 


Leu His Ile His Ser Asp Val Phe Ser Glu Pro Arg Ala Ile Phe Tyr 
705                 710                 715                 720 


Ser Ala Cys Val Val Leu Gly Leu Gln Phe Leu His Glu His Lys Ile 
                725                 730                 735     


Val Tyr Arg Asp Leu Lys Leu Asp Asn Leu Leu Leu Asp Thr Glu Gly 
            740                 745                 750         


Tyr Val Lys Ile Ala Asp Phe Gly Leu Cys Lys Glu Gly Met Gly Tyr 
        755                 760                 765             


Gly Asp Arg Thr Ser Thr Phe Cys Gly Thr Pro Glu Phe Leu Ala Pro 
    770                 775                 780                 


Glu Val Leu Thr Asp Thr Ser Tyr Thr Arg Ala Val Asp Trp Trp Gly 
785                 790                 795                 800 


Leu Gly Val Leu Leu Tyr Glu Met Leu Val Gly Glu Ser Pro Phe Pro 
                805                 810                 815     


Gly Asp Asp Glu Glu Glu Val Phe Asp Ser Ile Val Asn Asp Glu Val 
            820                 825                 830         


Arg Tyr Pro Arg Phe Leu Ser Ala Glu Ala Ile Gly Ile Met Arg Arg 
        835                 840                 845             


Leu Leu Arg Arg Asn Pro Glu Arg Arg Leu Gly Ser Ser Glu Arg Asp 
    850                 855                 860                 


Ala Glu Asp Val Lys Lys Gln Pro Phe Phe Arg Thr Leu Gly Trp Glu 
865                 870                 875                 880 


Ala Leu Leu Ala Arg Arg Leu Pro Pro Pro Phe Val Pro Thr Leu Ser 
                885                 890                 895     


Gly Arg Thr Asp Val Ser Asn Phe Asp Glu Glu Phe Thr Gly Glu Ala 
            900                 905                 910         


Pro Thr Leu Ser Pro Pro Arg Asp Ala Arg Pro Leu Thr Ala Ala Glu 
        915                 920                 925             


Gln Ala Ala Phe Leu Asp Phe Asp Phe Val Ala Gly Gly Cys 
    930                 935                 940         


<210>  9257
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PKN1__Homo_sapiens__BAA05169

<400>  9257
auggccagcg acgccgugca gagugagccu cgcagcuggu cccugcuaga gcagcugggc       60

cuggccgggg cagaccuggc ggcccccggg guacagcagc agcuggagcu ggagcgggag      120

cggcugcggc gggaaauccg caaggagcug aagcugaagg agggugcuga gaaccugcgg      180

cgggccacca cugaccuggg ccgcagccug ggccccguag agcugcugcu gcggggcucc      240

ucgcgccgcc ucgaccugcu gcaccagcag cugcaggagc ugcacgccca cguggugcuu      300

cccgacccgg cggccaccca cgauggcccc caguccccug gugcgggugg ccccaccugc      360

ucggccacca accugagccg cguggcgggc cuggagaagc aguuggccau ugagcugaag      420

gugaagcagg gggcggagaa caugauccag accuacagca auggcagcac caaggaccgg      480

aagcugcugc ugacagccca gcagauguug caggacagua agaccaagau ugacaucauc      540

cgcaugcaac uccgccgggc gcugcaggcc ggccagcugg agaaccaggc agccccggau      600

gacacccaag ggaguccuga ccugggggcu guggagcugc gcaucgaaga gcugcggcac      660

cacuuccgag uggagcacgc gguggccgag ggugccaaga acguacugcg ccugcucagc      720

gcugccaagg ccccggaccg caaggcaguc agcgaggccc aggagaaauu gacagaaucc      780

aaccagaagc uggggcugcu gcgggaggcu cuggagcgga gacuugggga gcugcccgcc      840

gaccacccca aggggcggcu gcugcgagaa gagcucgcug cggccuccuc cgcugccuuc      900

agcacccgcc uggccgggcc cuuucccgcc acgcacuaca gcacccugug caagcccgcg      960

ccgcucacag ggacccugga gguacgagug gugggcugca gagaccuccc agagaccauc     1020

ccguggaacc cuacccccuc aaugggggga ccugggaccc cagacagccg cccccccuuc     1080

cugagccgcc cagcccgggg ccuuuacagc cgaagcggaa gccucagugg ccggagcagc     1140

cucaaagcag aagccgagaa caccagugaa gucagcacug ugcuuaagcu ggauaacaca     1200

gugguggggc agacgucuug gaagccaugu ggccccaaug ccugggacca gagcuucacu     1260

cuggagcugg aaagggcacg ggaacuggag uuggcugugu ucuggcggga ccagcggggc     1320

cugugugccc ucaaauuccu gaaguuggag gauuucuugg acaaugagag gcaugaggug     1380

cagcuggaca uggaacccca gggcugccug guggcugagg ucaccuuccg caacccuguc     1440

auugagagga uuccucggcu ccgacggcag aagaaaauuu ucuccaagca gcaagggaag     1500

gcguuccagc gugcuaggca gaugaacauc gaugucgcca cgugggugcg gcugcuccgg     1560

aggcucaucc ccaaugccac gggcacaggc accuuuagcc cuggggcuuc uccaggaucc     1620

gaggcccgga ccacggguga cauaucggug gagaagcuga accucggcac ugacucggac     1680

agcucaccuc agaagagcuc gcgggauccu ccuuccagcc caucgagccu gagcuccccc     1740

auccaggaau ccacugcucc cgagcugccu ucggagaccc aggagacccc aggccccgcc     1800

cugugcagcc cucugaggaa gucaccucug acccucgaag auuucaaguu ccuggcggug     1860

cugggccggg gucauuuugg gaaggugcuc cucuccgaau uccggcccag uggggagcug     1920

uucgccauca aggcucugaa gaaaggggac auuguggccc gagacgaggu ggagagccug     1980

augugugaga agcggauauu ggcggcagug accagugcgg gacaccccuu ccuggugaac     2040

cucuucggcu guuuccagac accggagcac gugugcuucg ugauggagua cucggccggu     2100

ggggaccuga ugcugcacau ccacagcgac guguucucug agccccgugc caucuuuuau     2160

uccgccugcg uggugcuggg ccuacaguuu cuucacgaac acaagaucgu cuacagggac     2220

cugaaguugg acaauuugcu ccuggacacc gagggcuacg ucaagaucgc agacuuuggc     2280

cucugcaagg aggggauggg cuauggggac cggaccagca cauucugugg gaccccggag     2340

uuccuggccc cugaggugcu gacggacacg ucguacacgc gagcugugga cuggugggga     2400

cugggugugc ugcucuacga gaugcugguu ggcgaguccc cauucccagg ggaugaugag     2460

gaggaggucu ucgacagcau cgucaacgac gagguucgcu acccccgcuu ccugucggcc     2520

gaagccaucg gcaucaugag aaggcugcuu cggaggaacc cagagcggag gcugggaucu     2580

agcgagagag augcagaaga ugugaagaaa cagcccuucu ucaggacucu gggcugggaa     2640

gcccuguugg cccggcgccu gccaccgccc uuugugccca cgcuguccgg ccgcaccgac     2700

gucagcaacu ucgacgagga guucaccggg gaggccccca cacugagccc gccccgcgac     2760

gcgcggcccc uuacagccgc ggagcaggca gccuuccugg acuucgacuu cguggccggg     2820

ggcugcuag                                                             2829


<210>  9258
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PKN1__Homo_sapiens__BAA05169

<400>  9258
auggccagcg acgccgugca guccgagccc cgcagcuggu cccugcucga gcagcugggc       60

cuggcggggg ccgaccucgc cgccccgggc guccagcagc agcuggagcu ggagcgggag      120

cgccuccggc gcgagauccg gaaggagcug aagcugaagg agggggccga gaaccuccgc      180

cgggcgacca ccgaccuggg ccgcagccug gggcccgugg agcuccugcu gcggggcucc      240

agccgccggc ucgaccugcu gcaccagcag cuccaggagc ugcacgccca cgugguccug      300

cccgaccccg ccgccacgca cgacggcccg cagucccccg gggcgggcgg gccgaccugc      360

agcgccacca accucucccg cguggccggc cuggagaagc agcuggccau cgagcucaag      420

gugaagcagg gggccgagaa caugauccag accuacagca acggcuccac gaaggaccgg      480

aagcugcugc ucaccgcgca gcagaugcug caggacagca agaccaagau cgacaucauc      540

cgcaugcagc ugcggcgcgc ccuccaggcc ggccagcugg agaaccaggc cgcccccgac      600

gacacccagg ggucccccga ccugggcgcg gucgagcucc ggaucgagga gcugcgccac      660

cacuuccggg uggagcacgc cguggccgag ggggccaaga acguccugcg ccuccugagc      720

gccgcgaagg cccccgaccg gaaggccgug uccgaggccc aggagaagcu gacggagagc      780

aaccagaagc ucggccugcu gcgcgaggcc cucgagcgcc ggcugggcga gcugcccgcg      840

gaccacccca aggggcgccu ccugcgggag gagcuggccg ccgccuccag cgcggccuuc      900

uccacccgcc ucgccggccc guuccccgcc acccacuaca gcacccugug caagcccgcg      960

ccccugacgg ggacccugga ggugcggguc gugggcugcc gcgaccuccc ggagaccauc     1020

cccuggaacc ccacccccag caugggcggg ccgggcacgc ccgacucccg gccgcccuuc     1080

cugagccgcc ccgcccgggg gcuguacucc cgcagcggcu cccucagcgg gcgguccagc     1140

cugaaggccg aggccgagaa caccuccgag gugagcaccg uccugaagcu cgacaacacc     1200

guggugggcc agacguccug gaagcccugc gggcccaacg ccugggacca gagcuucacc     1260

cuggagcugg agcgcgcccg ggagcucgag cuggcggucu ucuggcgcga ccagcggggc     1320

cugugcgccc ucaaguuccu gaagcuggag gacuuccucg acaacgagcg ccacgaggug     1380

cagcuggaca uggagcccca gggcugccug guggccgagg ucaccuuccg gaacccggug     1440

aucgagcgca ucccccggcu ccgccgccag aagaagaucu ucuccaagca gcaggggaag     1500

gccuuccagc gggcccgcca gaugaacauc gacguggcga ccuggguccg gcugcugcgc     1560

cggcucaucc ccaacgccac gggcaccggg accuucagcc cgggcgccuc ccccgggagc     1620

gaggcccgca ccacgggcga caucuccgug gagaagcuga accugggcac cgacagcgac     1680

uccagccccc agaaguccag ccgggacccg cccagcuccc ccagcucccu cagcuccccc     1740

auccaggaga gcaccgcgcc cgagcugccg uccgagaccc aggagacgcc cgggcccgcc     1800

cugugcagcc cccuccgcaa guccccgcug acccuggagg acuucaaguu ccucgccguc     1860

cugggccggg ggcacuucgg caaggugcug cucagcgagu uccgccccuc cggcgagcug     1920

uucgccauca aggcccugaa gaagggggac aucguggcgc gggacgaggu cgagagccuc     1980

augugcgaga agcgcauccu ggccgccgug accuccgccg gccaccccuu ccuggugaac     2040

cucuucgggu gcuuccagac ccccgagcac gucugcuucg ugauggagua cagcgccggc     2100

ggggaccuga ugcugcacau ccacuccgac guguucagcg agccgcgggc gaucuucuac     2160

agcgccugcg ucgugcucgg ccugcaguuc cugcacgagc acaagaucgu guaccgcgac     2220

cucaagcugg acaaccugcu ccuggacacg gagggcuacg ucaagaucgc cgacuucggg     2280

cugugcaagg agggcauggg guacggcgac cggaccucca ccuucugcgg gacccccgag     2340

uuccucgccc ccgaggugcu gaccgacacg agcuacaccc gcgccgugga cugguggggc     2400

cugggcgucc uccuguacga gaugcuggug ggggaguccc ccuucccggg cgacgacgag     2460

gaggaggugu ucgacagcau cgucaacgac gaggugcggu acccccgcuu ccucuccgcg     2520

gaggccaucg ggaucaugcg gcgccugcug cggcgcaacc ccgagcgccg gcucggcagc     2580

uccgagcgcg acgccgagga cgugaagaag cagcccuucu uccggacccu ggggugggag     2640

gcccugcucg cgcgccggcu gccgccgccc uucgucccca cccugagcgg ccgcacggac     2700

guguccaacu ucgacgagga guucaccggc gaggccccca cccucagccc gccccgggac     2760

gcccgccccc ugaccgccgc cgagcaggcg gccuuccugg acuucgacuu cguggccggg     2820

ggcugcuga                                                             2829


<210>  9259
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PKN1__Homo_sapiens__BAA05169

<400>  9259
auggccuccg acgccgucca guccgagccc cgcuccuggu cccuccucga gcagcucggc       60

cucgccggcg ccgaccucgc cgcccccggc guccagcagc agcucgagcu cgagcgcgag      120

cgccuccgcc gcgagauccg caaggagcuc aagcucaagg agggcgccga gaaccuccgc      180

cgcgccacca ccgaccucgg ccgcucccuc ggccccgucg agcuccuccu ccgcggcucc      240

ucccgccgcc ucgaccuccu ccaccagcag cuccaggagc uccacgccca cgucguccuc      300

cccgaccccg ccgccaccca cgacggcccc cagucccccg gcgccggcgg ccccaccugc      360

uccgccacca accucucccg cgucgccggc cucgagaagc agcucgccau cgagcucaag      420

gucaagcagg gcgccgagaa caugauccag accuacucca acggcuccac caaggaccgc      480

aagcuccucc ucaccgccca gcagaugcuc caggacucca agaccaagau cgacaucauc      540

cgcaugcagc uccgccgcgc ccuccaggcc ggccagcucg agaaccaggc cgcccccgac      600

gacacccagg gcucccccga ccucggcgcc gucgagcucc gcaucgagga gcuccgccac      660

cacuuccgcg ucgagcacgc cgucgccgag ggcgccaaga acguccuccg ccuccucucc      720

gccgccaagg cccccgaccg caaggccguc uccgaggccc aggagaagcu caccgagucc      780

aaccagaagc ucggccuccu ccgcgaggcc cucgagcgcc gccucggcga gcuccccgcc      840

gaccacccca agggccgccu ccuccgcgag gagcucgccg ccgccuccuc cgccgccuuc      900

uccacccgcc ucgccggccc cuuccccgcc acccacuacu ccacccucug caagcccgcc      960

ccccucaccg gcacccucga gguccgcguc gucggcugcc gcgaccuccc cgagaccauc     1020

cccuggaacc ccacccccuc caugggcggc cccggcaccc ccgacucccg cccccccuuc     1080

cucucccgcc ccgcccgcgg ccucuacucc cgcuccggcu cccucuccgg ccgcuccucc     1140

cucaaggccg aggccgagaa caccuccgag gucuccaccg uccucaagcu cgacaacacc     1200

gucgucggcc agaccuccug gaagcccugc ggccccaacg ccugggacca guccuucacc     1260

cucgagcucg agcgcgcccg cgagcucgag cucgccgucu ucuggcgcga ccagcgcggc     1320

cucugcgccc ucaaguuccu caagcucgag gacuuccucg acaacgagcg ccacgagguc     1380

cagcucgaca uggagcccca gggcugccuc gucgccgagg ucaccuuccg caaccccguc     1440

aucgagcgca ucccccgccu ccgccgccag aagaagaucu ucuccaagca gcagggcaag     1500

gccuuccagc gcgcccgcca gaugaacauc gacgucgcca ccuggguccg ccuccuccgc     1560

cgccucaucc ccaacgccac cggcaccggc accuucuccc ccggcgccuc ccccggcucc     1620

gaggcccgca ccaccggcga caucuccguc gagaagcuca accucggcac cgacuccgac     1680

uccucccccc agaaguccuc ccgcgacccc cccuccuccc ccuccucccu cuccuccccc     1740

auccaggagu ccaccgcccc cgagcucccc uccgagaccc aggagacccc cggccccgcc     1800

cucugcuccc cccuccgcaa guccccccuc acccucgagg acuucaaguu ccucgccguc     1860

cucggccgcg gccacuucgg caagguccuc cucuccgagu uccgccccuc cggcgagcuc     1920

uucgccauca aggcccucaa gaagggcgac aucgucgccc gcgacgaggu cgagucccuc     1980

augugcgaga agcgcauccu cgccgccguc accuccgccg gccaccccuu ccucgucaac     2040

cucuucggcu gcuuccagac ccccgagcac gucugcuucg ucauggagua cuccgccggc     2100

ggcgaccuca ugcuccacau ccacuccgac gucuucuccg agccccgcgc caucuucuac     2160

uccgccugcg ucguccucgg ccuccaguuc cuccacgagc acaagaucgu cuaccgcgac     2220

cucaagcucg acaaccuccu ccucgacacc gagggcuacg ucaagaucgc cgacuucggc     2280

cucugcaagg agggcauggg cuacggcgac cgcaccucca ccuucugcgg cacccccgag     2340

uuccucgccc ccgagguccu caccgacacc uccuacaccc gcgccgucga cugguggggc     2400

cucggcgucc uccucuacga gaugcucguc ggcgaguccc ccuuccccgg cgacgacgag     2460

gaggaggucu ucgacuccau cgucaacgac gagguccgcu acccccgcuu ccucuccgcc     2520

gaggccaucg gcaucaugcg ccgccuccuc cgccgcaacc ccgagcgccg ccucggcucc     2580

uccgagcgcg acgccgagga cgucaagaag cagcccuucu uccgcacccu cggcugggag     2640

gcccuccucg cccgccgccu cccccccccc uucgucccca cccucuccgg ccgcaccgac     2700

gucuccaacu ucgacgagga guucaccggc gaggccccca cccucucccc cccccgcgac     2760

gcccgccccc ucaccgccgc cgagcaggcc gccuuccucg acuucgacuu cgucgccggc     2820

ggcugcuga                                                             2829


<210>  9260
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PKN1__Homo_sapiens__BAA05169

<400>  9260
auggccagcg acgcugugca guccgagccc agaucuuggu cacugcucga acaacuuggc       60

cuggcagggg ccgauuuggc ggcuccugga guccagcagc aguuagagcu ggaaagggag      120

cggcuacgcc gagaaauccg uaaggagcuc aaacugaagg agggugccga aaaccuuaga      180

agggcaacca cagaccuggg ccggaguuug gggccaguug agcuccugcu gcgcggaagc      240

uccagaaggc ucgauuuacu gcaccaacag cuucaggaau ugcaugccca cgugguacug      300

ccggaccccg cugcaacuca ugauggcccu cagucuccag gugccggggg acccacgugc      360

ucggcuacca aucuaucacg gguggccggc cucgagaaac aacuggcgau ugagcuuaag      420

gucaaacagg gcgcagaaaa caugauacag acauacagca augggaguac uaaggaccgc      480

aagcuguugc ucaccgccca gcaaaugcug caggauucca aaacaaagau cgacauuauc      540

cgaaugcagu uaagaagggc ucugcaagcc ggacagcucg agaaccaggc agcuccugau      600

gacacccagg guucuccaga ucuuggcgcc guggaacugc ggauugagga auugcgucac      660

cauuuccgcg uugagcacgc gguggccgag ggggcaaaga auguccuaag acugcucagc      720

gcugccaagg cucccgacag gaaagccgug uccgaagcac aagagaagcu gacugaauca      780

aaccagaaac uuggacuguu gcgggaggcc cucgaacgac gccugggcga guuaccugcu      840

gaucacccaa aagguagacu gcuaagggag gaacucgcgg cagccaguag cgcugccuuu      900

ucuacacggc uggcagggcc guuccccgcc acccauuauu ccacgcuuug uaagccugcu      960

ccauugacug gaacccugga gguacgcguu gugggcugca gagaccuccc cgaaacaauc     1020

ccuuggaauc caacucccuc aaugggcggg ccgggaaccc cugacagcag gcccccauuu     1080

cugagucguc cugcccgggg ucuuuacucu cgauccggca gccugucggg gagaucuucc     1140

uugaaagcag aggcggaaaa cacaucagag gucaguaccg ugcucaagcu ggauaauacg     1200

guggucggac agacuagcug gaaacccugu ggcccaaacg cuugggacca guccuucaca     1260

uuagagcugg aaagggcccg cgagcuagaa cucgcaguuu ucuggcggga ucaaagaggu     1320

cugugcgccc uuaaguucuu gaaacuggag gacuuucucg auaaugagag gcacgaagug     1380

cagcuggaca uggagcccca gggguguuua guagcugaag ugaccuuccg caacccuguc     1440

auagagcgaa ucccacggcu gcguagacag aagaagaucu uuucuaaaca acagggcaag     1500

gccuuccaga gggcacgcca gaugaauauu gauguggcua cuuggguucg gcuuuugaga     1560

aggcucauuc cgaacgccac aggaaccggc acguuuagcc ccggggcguc accuggaagu     1620

gaagcccgaa ccacagguga caucuccgug gagaaacuga aucuaggcac ugauagcgac     1680

ucuucaccac aaaagaguag ccgcgauccc ccuuccucuc caucgagccu guccucaccc     1740

auacaggaga guaccgcucc ggaacucccu ucugagacac aggaaacucc agggcccgca     1800

cugugcagcc cucuucggaa aucccccuug acccuggagg acuucaaguu uuuagccguc     1860

cucggaagag gccauuucgg uaaggugcug cuuucagaau uuaggccaag cggggagcug     1920

uuugcuauua aagccuugaa gaaaggcgac aucguagcac gugaugaggu ugaaucucuc     1980

augugugaga agcgcauucu ggcggccgug acauccgcug gacacccuuu ccuagucaac     2040

cuguuuggcu gcuuccaaac ccccgaacac guguguuuug ucauggagua uagugccggg     2100

ggagaccuca ugcugcauau ccacagcgau guguucucug aaccacgggc aaucuuuuac     2160

uccgcuugcg uugugcuugg uuugcaguuc cugcaugagc acaaaauugu auauagagac     2220

uuaaagcucg auaaccugcu ucuggacacu gagggcuacg ucaagauagc cgauuuuggg     2280

cuauguaaag aaggaauggg cuauggugac aggacgucaa cauucugcgg gaccccggag     2340

uuucucgcac cugaagugcu gacugauacc aguuacacac gagccguuga cugguggggc     2400

uugggagugc uguuauacga gaugcucguc ggcgagagcc ccuucccagg ggaugacgaa     2460

gaggaagugu uugauucgau cguaaaugac gaggugcggu auccccgcuu ccuguccgcu     2520

gaagcgauug gaaucaugag aaggcuucug cggcgaaacc cugagagacg cuugggcucu     2580

agcgagaggg acgccgaaga uguuaagaaa cagccauucu uucguacccu cgguugggag     2640

gcacugcuag cucggagacu gcccccuccg uucgucccaa cucuuucagg gaggacagac     2700

gugaguaauu uugaugaaga guucacggga gaagccccca cccucucccc uccacgcgac     2760

gcccgacccc ugacugcugc agagcaggcc gcguuuuugg auuucgacuu uguggcuggc     2820

gguugcuga                                                             2829


<210>  9261
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PKN1__Homo_sapiens__BAA05169

<400>  9261
auggccagcg acgccgugca gagcgagccc agaagcugga gccugcugga gcagcugggc       60

cuggccggcg ccgaccuggc cgcccccggc gugcagcagc agcuggagcu ggagagagag      120

agacugagaa gagagaucag aaaggagcug aagcugaagg agggcgccga gaaccugaga      180

agagccacca ccgaccuggg cagaagccug ggccccgugg agcugcugcu gagaggcagc      240

agcagaagac uggaccugcu gcaccagcag cugcaggagc ugcacgccca cguggugcug      300

cccgaccccg ccgccaccca cgacggcccc cagagccccg gcgccggcgg ccccaccugc      360

agcgccacca accugagcag aguggccggc cuggagaagc agcuggccau cgagcugaag      420

gugaagcagg gcgccgagaa caugauccag accuacagca acggcagcac caaggacaga      480

aagcugcugc ugaccgccca gcagaugcug caggacagca agaccaagau cgacaucauc      540

agaaugcagc ugagaagagc ccugcaggcc ggccagcugg agaaccaggc cgcccccgac      600

gacacccagg gcagccccga ccugggcgcc guggagcuga gaaucgagga gcugagacac      660

cacuucagag uggagcacgc cguggccgag ggcgccaaga acgugcugag acugcugagc      720

gccgccaagg cccccgacag aaaggccgug agcgaggccc aggagaagcu gaccgagagc      780

aaccagaagc ugggccugcu gagagaggcc cuggagagaa gacugggcga gcugcccgcc      840

gaccacccca agggcagacu gcugagagag gagcuggccg ccgccagcag cgccgccuuc      900

agcaccagac uggccggccc cuuccccgcc acccacuaca gcacccugug caagcccgcc      960

ccccugaccg gcacccugga ggugagagug gugggcugca gagaccugcc cgagaccauc     1020

cccuggaacc ccacccccag caugggcggc cccggcaccc ccgacagcag accccccuuc     1080

cugagcagac ccgccagagg ccuguacagc agaagcggca gccugagcgg cagaagcagc     1140

cugaaggccg aggccgagaa caccagcgag gugagcaccg ugcugaagcu ggacaacacc     1200

guggugggcc agaccagcug gaagcccugc ggccccaacg ccugggacca gagcuucacc     1260

cuggagcugg agagagccag agagcuggag cuggccgugu ucuggagaga ccagagaggc     1320

cugugcgccc ugaaguuccu gaagcuggag gacuuccugg acaacgagag acacgaggug     1380

cagcuggaca uggagcccca gggcugccug guggccgagg ugaccuucag aaaccccgug     1440

aucgagagaa uccccagacu gagaagacag aagaagaucu ucagcaagca gcagggcaag     1500

gccuuccaga gagccagaca gaugaacauc gacguggcca ccugggugag acugcugaga     1560

agacugaucc ccaacgccac cggcaccggc accuucagcc ccggcgccag ccccggcagc     1620

gaggccagaa ccaccggcga caucagcgug gagaagcuga accugggcac cgacagcgac     1680

agcagccccc agaagagcag cagagacccc cccagcagcc ccagcagccu gagcagcccc     1740

auccaggaga gcaccgcccc cgagcugccc agcgagaccc aggagacccc cggccccgcc     1800

cugugcagcc cccugagaaa gagcccccug acccuggagg acuucaaguu ccuggccgug     1860

cugggcagag gccacuucgg caaggugcug cugagcgagu ucagacccag cggcgagcug     1920

uucgccauca aggcccugaa gaagggcgac aucguggcca gagacgaggu ggagagccug     1980

augugcgaga agagaauccu ggccgccgug accagcgccg gccaccccuu ccuggugaac     2040

cuguucggcu gcuuccagac ccccgagcac gugugcuucg ugauggagua cagcgccggc     2100

ggcgaccuga ugcugcacau ccacagcgac guguucagcg agcccagagc caucuucuac     2160

agcgccugcg uggugcuggg ccugcaguuc cugcacgagc acaagaucgu guacagagac     2220

cugaagcugg acaaccugcu gcuggacacc gagggcuacg ugaagaucgc cgacuucggc     2280

cugugcaagg agggcauggg cuacggcgac agaaccagca ccuucugcgg cacccccgag     2340

uuccuggccc ccgaggugcu gaccgacacc agcuacacca gagccgugga cugguggggc     2400

cugggcgugc ugcuguacga gaugcuggug ggcgagagcc ccuuccccgg cgacgacgag     2460

gaggaggugu ucgacagcau cgugaacgac gaggugagau accccagauu ccugagcgcc     2520

gaggccaucg gcaucaugag aagacugcug agaagaaacc ccgagagaag acugggcagc     2580

agcgagagag acgccgagga cgugaagaag cagcccuucu ucagaacccu gggcugggag     2640

gcccugcugg ccagaagacu gccccccccc uucgugccca cccugagcgg cagaaccgac     2700

gugagcaacu ucgacgagga guucaccggc gaggccccca cccugagccc ccccagagac     2760

gccagacccc ugaccgccgc cgagcaggcc gccuuccugg acuucgacuu cguggccggc     2820

ggcugcuga                                                             2829


<210>  9262
<211>  2829
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PKN1__Homo_sapiens__BAA05169

<400>  9262
auggccagcg acgcugugca guccgagccc agaucuugga gccugcucga acaacugggc       60

cuugccgggg cggaucuggc ugccccugga guccagcagc agcucgagcu ggaacgggag      120

cgccuuagac gggaaauccg caaggagcug aaacucaagg agggcgccga aaaccugaga      180

cgggcuacca cagaccuggg gcgcucccuc ggaccgguug agcugcuucu gagaggcucu      240

agccggcgcc ucgaucugcu ucaccaacag cugcaggaac uccaugccca cguggugcug      300

cccgacccug cugccacgca ugaugggccc caguccccug gagcgggcgg cccuaccugc      360

ucugccacaa aucugagcag agucgcuggg cucgagaaac aacuggccau ugagcuuaag      420

gugaaacagg gagcugaaaa caugauccag accuacucca auggcagcac aaaggaccgg      480

aagcugcucc ugaccgccca gcaaaugcuu caggauucua aaacaaagau ugacaucauu      540

cgcaugcagc ugagacgggc gcuccaagcc gggcagcugg agaaccaggc ugcccccgau      600

gacacccagg gauccccgga ucugggcgcu guugaacucc gcaucgagga acugagacac      660

cauuuccggg uggagcacgc cgucgccgag ggggcuaaaa augugcuuag acugcucagc      720

gcggccaagg cucccgaccg caaagccguu ucugaagccc aagagaagcu gacggaaucc      780

aaccagaaac uuggacugcu ccgggaggcu cuggaaagac gccugggcga gcucccugcc      840

gaucacccca agggccggcu gcuuagagag gaacuggcgg cugccagcuc ugccgcuuuu      900

uccacccgcc ucgccgggcc uuuccccgcu acacauuaua gcacccugug uaagccggcc      960

ccucugacag gaacccuuga ggugcggguc gugggcugca gagaccuccc cgaaacgauc     1020

ccuuggaauc ccacacccuc caugggaggg ccuggcaccc cggacucucg gcccccuuuu     1080

cugagccgcc ccgcgagagg gcuguacucc cgcagcggau cucucuccgg ccggagcucu     1140

cugaaagccg aggcugaaaa cacaagcgag guguccaccg uccuuaagcu ggauaauacc     1200

guugugggcc agacaucuug gaaaccuugu gggcccaacg ccugggacca gagcuucacg     1260

cucgagcugg aaagagcucg ggagcuggaa cuugccgugu uuuggcgcga ucaaagagga     1320

cucugcgcgc ugaaguuccu gaaacucgag gacuuucugg auaaugagcg gcacgaaguc     1380

cagcuugaca uggagccgca gggcugucug guggccgaag uuaccuucag aaacccugug     1440

auugagcgca ucccccggcu cagacgccag aagaagauuu ucuccaaaca acaggggaag     1500

gcuuuccaga gagcccggca gaugaauauc gaugucgcua caugggugcg ccugcugaga     1560

cggcuuauuc cuaacgccac cggaacaggc accuuuagcc ccggggccuc uccuggcucc     1620

gaagcucgca cgacaggaga caucagcguu gagaaacuca aucugggcac cgauucugac     1680

uccagccccc aaaaguccuc uagagauccg ccuagcuccc ccucuagccu guccagcccc     1740

auucaggagu cuaccgcgcc ugaacucccg uccgagacac aggaaacccc cgggccugcc     1800

cugugcagcc cccuucggaa aucuccucug acacucgagg acuucaaguu ucuggcugug     1860

cugggacgcg gccauuucgg gaagguccuu cucuccgaau uuagacccag cggagagcug     1920

uuugccauca aagcccugaa gaaaggcgac aucguggcuc gggaugaggu cgaaucucuc     1980

augugugaga agcgcauucu ggccgcggug acgagcgcug ggcacccuuu ccuuguuaac     2040

cuguuuggcu gcuuccaaac ccccgaacac guguguuuug ucauggagua uuccgccgga     2100

ggcgaccuca ugcugcauau ccacagcgau guguucucug aaccgagagc caucuuuuac     2160

uccgcuugcg uugugcuggg gcuucaguuc cugcaugagc acaaaauugu cuaucgggac     2220

cucaagcugg auaaccuccu gcuugacaca gagggauacg ugaagauugc cgauuuuggc     2280

cuguguaaag aagggauggg auauggcgac agaaccagca cauucugcgg gaccccugag     2340

uuucucgcgc ccgaagugcu gacggauacc uccuacacac gcgcuguuga cugguggggc     2400

cugggagucc uucuguacga gaugcucgug ggcgagucuc cuuuccccgg ggaugacgaa     2460

gaggaagugu uugauagcau cgucaaugac gaggugcggu auccgagauu ccuguccgcc     2520

gaagccaucg gaauuaugcg ccggcuccug agacgcaacc cugagcggag acuuggcucu     2580

agcgagcgcg acgcugaaga uguuaagaaa cagcccuucu uucggacccu ggggugggag     2640

gcccuccugg cuagacggcu gccuccuccc uucgugccca cacuuuccgg acgcaccgac     2700

gucucuaauu uugaugaaga guucacgggc gaagccccga cacugagccc ucccagagac     2760

gcgcggcccc ucaccgccgc ugagcaggcc gcuuuucugg auuucgacuu uguggccggg     2820

ggcugcuga                                                             2829


<210>  9263
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PKN2__Homo_sapiens__Q16513

<400>  9263

Met Ala Ser Asn Pro Glu Arg Gly Glu Ile Leu Leu Thr Glu Leu Gln 
1               5                   10                  15      


Gly Asp Ser Arg Ser Leu Pro Phe Ser Glu Asn Val Ser Ala Val Gln 
            20                  25                  30          


Lys Leu Asp Phe Ser Asp Thr Met Val Gln Gln Lys Leu Asp Asp Ile 
        35                  40                  45              


Lys Asp Arg Ile Lys Arg Glu Ile Arg Lys Glu Leu Lys Ile Lys Glu 
    50                  55                  60                  


Gly Ala Glu Asn Leu Arg Lys Val Thr Thr Asp Lys Lys Ser Leu Ala 
65                  70                  75                  80  


Tyr Val Asp Asn Ile Leu Lys Lys Ser Asn Lys Lys Leu Glu Glu Leu 
                85                  90                  95      


His His Lys Leu Gln Glu Leu Asn Ala His Ile Val Val Ser Asp Pro 
            100                 105                 110         


Glu Asp Ile Thr Asp Cys Pro Arg Thr Pro Asp Thr Pro Asn Asn Asp 
        115                 120                 125             


Pro Arg Cys Ser Thr Ser Asn Asn Arg Leu Lys Ala Leu Gln Lys Gln 
    130                 135                 140                 


Leu Asp Ile Glu Leu Lys Val Lys Gln Gly Ala Glu Asn Met Ile Gln 
145                 150                 155                 160 


Met Tyr Ser Asn Gly Ser Ser Lys Asp Arg Lys Leu His Gly Thr Ala 
                165                 170                 175     


Gln Gln Leu Leu Gln Asp Ser Lys Thr Lys Ile Glu Val Ile Arg Met 
            180                 185                 190         


Gln Ile Leu Gln Ala Val Gln Thr Asn Glu Leu Ala Phe Asp Asn Ala 
        195                 200                 205             


Lys Pro Val Ile Ser Pro Leu Glu Leu Arg Met Glu Glu Leu Arg His 
    210                 215                 220                 


His Phe Arg Ile Glu Phe Ala Val Ala Glu Gly Ala Lys Asn Val Met 
225                 230                 235                 240 


Lys Leu Leu Gly Ser Gly Lys Val Thr Asp Arg Lys Ala Leu Ser Glu 
                245                 250                 255     


Ala Gln Ala Arg Phe Asn Glu Ser Ser Gln Lys Leu Asp Leu Leu Lys 
            260                 265                 270         


Tyr Ser Leu Glu Gln Arg Leu Asn Glu Val Pro Lys Asn His Pro Lys 
        275                 280                 285             


Ser Arg Ile Ile Ile Glu Glu Leu Ser Leu Val Ala Ala Ser Pro Thr 
    290                 295                 300                 


Leu Ser Pro Arg Gln Ser Met Ile Ser Thr Gln Asn Gln Tyr Ser Thr 
305                 310                 315                 320 


Leu Ser Lys Pro Ala Ala Leu Thr Gly Thr Leu Glu Val Arg Leu Met 
                325                 330                 335     


Gly Cys Gln Asp Ile Leu Glu Asn Val Pro Gly Arg Ser Lys Ala Thr 
            340                 345                 350         


Ser Val Ala Leu Pro Gly Trp Ser Pro Ser Glu Thr Arg Ser Ser Phe 
        355                 360                 365             


Met Ser Arg Thr Ser Lys Ser Lys Ser Gly Ser Ser Arg Asn Leu Leu 
    370                 375                 380                 


Lys Thr Asp Asp Leu Ser Asn Asp Val Cys Ala Val Leu Lys Leu Asp 
385                 390                 395                 400 


Asn Thr Val Val Gly Gln Thr Ser Trp Lys Pro Ile Ser Asn Gln Ser 
                405                 410                 415     


Trp Asp Gln Lys Phe Thr Leu Glu Leu Asp Arg Ser Arg Glu Leu Glu 
            420                 425                 430         


Ile Ser Val Tyr Trp Arg Asp Trp Arg Ser Leu Cys Ala Val Lys Phe 
        435                 440                 445             


Leu Arg Leu Glu Asp Phe Leu Asp Asn Gln Arg His Gly Met Cys Leu 
    450                 455                 460                 


Tyr Leu Glu Pro Gln Gly Thr Leu Phe Ala Glu Val Thr Phe Phe Asn 
465                 470                 475                 480 


Pro Val Ile Glu Arg Arg Pro Lys Leu Gln Arg Gln Lys Lys Ile Phe 
                485                 490                 495     


Ser Lys Gln Gln Gly Lys Thr Phe Leu Arg Ala Pro Gln Met Asn Ile 
            500                 505                 510         


Asn Ile Ala Thr Trp Gly Arg Leu Val Arg Arg Ala Ile Pro Thr Val 
        515                 520                 525             


Asn His Ser Gly Thr Phe Ser Pro Gln Ala Pro Val Pro Thr Thr Val 
    530                 535                 540                 


Pro Val Val Asp Val Arg Ile Pro Gln Leu Ala Pro Pro Ala Ser Asp 
545                 550                 555                 560 


Ser Thr Val Thr Lys Leu Asp Phe Asp Leu Glu Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Arg Ala Ser Ser Leu Gly Glu Ile Asp Glu Ser Ser Glu 
            580                 585                 590         


Leu Arg Val Leu Asp Ile Pro Gly Gln Asp Ser Glu Thr Val Phe Asp 
        595                 600                 605             


Ile Gln Asn Asp Arg Asn Ser Ile Leu Pro Lys Ser Gln Ser Glu Tyr 
    610                 615                 620                 


Lys Pro Asp Thr Pro Gln Ser Gly Leu Glu Tyr Ser Gly Ile Gln Glu 
625                 630                 635                 640 


Leu Glu Asp Arg Arg Ser Gln Gln Arg Phe Gln Phe Asn Leu Gln Asp 
                645                 650                 655     


Phe Arg Cys Cys Ala Val Leu Gly Arg Gly His Phe Gly Lys Val Leu 
            660                 665                 670         


Leu Ala Glu Tyr Lys Asn Thr Asn Glu Met Phe Ala Ile Lys Ala Leu 
        675                 680                 685             


Lys Lys Gly Asp Ile Val Ala Arg Asp Glu Val Asp Ser Leu Met Cys 
    690                 695                 700                 


Glu Lys Arg Ile Phe Glu Thr Val Asn Ser Val Arg His Pro Phe Leu 
705                 710                 715                 720 


Val Asn Leu Phe Ala Cys Phe Gln Thr Lys Glu His Val Cys Phe Val 
                725                 730                 735     


Met Glu Tyr Ala Ala Gly Gly Asp Leu Met Met His Ile His Thr Asp 
            740                 745                 750         


Val Phe Ser Glu Pro Arg Ala Val Phe Tyr Ala Ala Cys Val Val Leu 
        755                 760                 765             


Gly Leu Gln Tyr Leu His Glu His Lys Ile Val Tyr Arg Asp Leu Lys 
    770                 775                 780                 


Leu Asp Asn Leu Leu Leu Asp Thr Glu Gly Phe Val Lys Ile Ala Asp 
785                 790                 795                 800 


Phe Gly Leu Cys Lys Glu Gly Met Gly Tyr Gly Asp Arg Thr Ser Thr 
                805                 810                 815     


Phe Cys Gly Thr Pro Glu Phe Leu Ala Pro Glu Val Leu Thr Glu Thr 
            820                 825                 830         


Ser Tyr Thr Arg Ala Val Asp Trp Trp Gly Leu Gly Val Leu Ile Tyr 
        835                 840                 845             


Glu Met Leu Val Gly Glu Ser Pro Phe Pro Gly Asp Asp Glu Glu Glu 
    850                 855                 860                 


Val Phe Asp Ser Ile Val Asn Asp Glu Val Arg Tyr Pro Arg Phe Leu 
865                 870                 875                 880 


Ser Thr Glu Ala Ile Ser Ile Met Arg Arg Leu Leu Arg Arg Asn Pro 
                885                 890                 895     


Glu Arg Arg Leu Gly Ala Ser Glu Lys Asp Ala Glu Asp Val Lys Lys 
            900                 905                 910         


His Pro Phe Phe Arg Leu Ile Asp Trp Ser Ala Leu Met Asp Lys Lys 
        915                 920                 925             


Val Lys Pro Pro Phe Ile Pro Thr Ile Arg Gly Arg Glu Asp Val Ser 
    930                 935                 940                 


Asn Phe Asp Asp Glu Phe Thr Ser Glu Ala Pro Ile Leu Thr Pro Pro 
945                 950                 955                 960 


Arg Glu Pro Arg Ile Leu Ser Glu Glu Glu Gln Glu Met Phe Arg Asp 
                965                 970                 975     


Phe Asp Tyr Ile Ala Asp Trp Cys 
            980                 


<210>  9264
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PKN2__Homo_sapiens__AAB33346

<400>  9264
auggcgucca accccgaacg gggggagauu cugcucacgg aacugcaggg ggauucccga       60

agucuuccgu uuucugagaa ugugagugcu guucaaaaau uagacuuuuc agauacaaug      120

gugcagcaga aauuggauga uaucaaggau cgaauuaaga gagaaauaag gaaagaacug      180

aaaaucaaag aaggagcuga aaaucugagg aaagucacaa cagauaaaaa aaguuuggcu      240

uauguagaca acauuuugaa aaaaucaaau aaaaaauuag aagaacuaca ucacaagcug      300

caggaauuaa augcacauau uguuguauca gauccagaag auauuacaga uugcccaagg      360

acuccagaua cuccaaauaa ugacccucgu uguucuacua gcaacaauag auugaaggcc      420

uuacaaaaac aauuggauau agaacuuaaa guaaaacaag gugcagagaa uaugauacag      480

auguauucaa auggaucuuc aaaggaucgg aaacuccaug guacagcuca gcaacugcuc      540

caggacagca agacaaaaau agaagucaua cgaaugcaga uucuucaggc aguccagacu      600

aaugaauugg cuuuugauaa ugcaaaaccu gugauaaguc cucuugaacu ucggauggaa      660

gaauuaaggc aucauuuuag gauagaguuu gcaguagcag aaggugcaaa gaauguaaug      720

aaauuacuug gcucaggaaa aguaacagac agaaaagcac uuucagaagc ucaagcaaga      780

uuuaaugaau caagucagaa guuggaccuu uuaaaguauu cauuagagca aagauuaaac      840

gaagucccca agaaucaucc caaaagcagg auuauuauug aagaacuuuc acuuguugcu      900

gcaucaccaa cacuaagucc acgucaaagu augauaucua cgcaaaauca auauaguaca      960

cuauccaaac cagcagcacu aacagguacu uuggaaguuc gucuuauggg cugccaagau     1020

auccuagaga augucccugg acggucaaaa gcaacaucag uugcacugcc ugguuggagu     1080

ccaagugaaa ccagaucauc uuucaugagc agaacgagua aaaguaaaag cggaaguagu     1140

cgaaaucuuc uaaaaaccga ugacuugucc aaugaugucu gugcuguuuu gaagcucgau     1200

aauacugugg uuggccaaac uagcuggaaa cccauuucca aucagucaug ggaccagaag     1260

uuuacacugg aacuggacag gucacgugaa cuggaaauuu caguuuauug gcgugauugg     1320

cggucucugu gugcuguaaa auuucugagg uuagaagauu uuuuagacaa ccaacggcau     1380

ggcauguguc ucuauuugga accacagggu acuuuauuug cagagguuac cuuuuuuaau     1440

ccaguuauug aaagaagacc aaaacuucaa agacaaaaga aaauuuuuuc aaagcaacaa     1500

ggcaaaacau uucucagagc uccucaaaug aauauuaaua uugccacuug gggaaggcua     1560

guaagaagag cuauuccuac aguaaaucau ucuggcaccu ucagcccuca agcuccugug     1620

ccuacuacag ugccaguggu ugauguacgc aucccucaac uagcaccucc agcuagugau     1680

ucuacaguaa ccaaauugga cuuugaucuu gagccugaac cuccuccagc cccaccacga     1740

gcuucuucuc uuggagaaau agaugaaucu ucugaauuaa gaguuuugga uauaccagga     1800

caggauucag agacuguuuu ugauauucag aaugacagaa auaguauacu uccaaaaucu     1860

caaucugaau acaagccuga uacuccucag ucaggccuag aauauagugg uauucaagaa     1920

cuugaggaca gaagaucuca gcaaagguuu caguuuaauc uacaagauuu cagguguugu     1980

gcugucuugg gaagaggaca uuuuggaaag gugcuuuuag cugaauauaa aaacacaaau     2040

gagauguuug cuauaaaagc cuuaaagaaa ggagauauug uggcucgaga ugaaguagac     2100

agccugaugu gugaaaaaag aauuuuugaa acugugaaua guguaaggca ucccuuuuug     2160

gugaaccuuu uugcauguuu ccaaaccaaa gagcauguuu gcuuuguaau ggaauaugcu     2220

gccggugggg accuaaugau gcacauucau acugaugucu uuucugaacc aagagcugua     2280

uuuuaugcug cuuguguagu ucuuggguug caguauuuac augaacacaa aauuguuuau     2340

agagauuuga aauuggauaa cuuauugcua gauacagagg gcuuugugaa aauugcugau     2400

uuuggucuuu gcaaagaagg aaugggauau ggagauagaa caagcacauu uuguggcacu     2460

ccugaauuuc uugccccaga aguauuaaca gaaacuucuu auacaagggc uguagauugg     2520

uggggccuug gcgugcuuau auaugaaaug cuuguuggug agucucccuu uccuggugau     2580

gaugaagagg aaguuuuuga caguauugua aaugaugaag uaagguaucc aagguucuua     2640

ucuacagaag ccauuucuau aaugagaagg cuguuaagaa gaaauccuga acggcgccuu     2700

ggggcuagcg agaaagaugc agaggaugua aaaaagcacc cauuuuuccg gcuaauugau     2760

uggagcgcuc ugauggacaa aaaaguaaag ccaccauuua uaccuaccau aagaggacga     2820

gaagauguua guaauuuuga ugaugaauuu accucagaag caccuauucu gacuccaccu     2880

cgagaaccaa ggauacuuuc ggaagaggag caggaaaugu ucagagauuu ugacuacauu     2940

gcugauuggu guuaa                                                      2955


<210>  9265
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PKN2__Homo_sapiens__AAB33346

<400>  9265
auggccagca accccgagcg cggcgagauc cugcucaccg agcugcaggg ggacucccgg       60

agccugcccu ucuccgagaa cgugagcgcc guccagaagc ucgacuucuc cgacaccaug      120

gugcagcaga agcuggacga caucaaggac cgcaucaagc gggagauccg caaggagcug      180

aagaucaagg agggcgcgga gaaccuccgg aaggugacga ccgacaagaa gucccuggcc      240

uacgucgaca acauccugaa gaaguccaac aagaagcucg aggagcugca ccacaagcug      300

caggagcuca acgcccacau cguggugagc gaccccgagg acaucaccga cugcccccgc      360

acccccgaca cgccgaacaa cgacccccgg ugcuccacca gcaacaaccg ccugaaggcc      420

cugcagaagc agcucgacau cgagcugaag gucaagcagg gggccgagaa caugauccag      480

auguacucca acggcagcuc caaggaccgg aagcugcacg ggaccgcgca gcagcuccug      540

caggacagca agaccaagau cgaggugauc cgcaugcaga uccugcaggc cgugcagacg      600

aacgagcucg ccuucgacaa cgccaagccc gucaucagcc cccuggagcu gcggauggag      660

gagcuccgcc accacuuccg gaucgaguuc gcgguggccg agggcgccaa gaacgugaug      720

aagcugcugg gcuccgggaa ggucaccgac cgcaaggccc ucuccgaggc ccaggcgcgg      780

uucaacgaga gcucccagaa gcuggaccug cucaaguaca gccuggagca gcgccugaac      840

gaggugccga agaaccaccc caagagccgg aucaucaucg aggagcucuc ccugguggcc      900

gccagcccca cccugagccc ccgccagucc augaucucca cccagaacca guacagcacg      960

cucuccaagc cggccgcccu gaccggcacc cuggaggucc ggcucauggg gugccaggac     1020

auccuggaga acgugcccgg ccgcagcaag gcgaccagcg uggcccugcc cggguggagc     1080

cccuccgaga cgcggagcuc cuucaugagc cgcaccucca agagcaaguc cggcagcucc     1140

cgcaaccucc ugaagaccga cgaccugagc aacgacgucu gcgccgugcu caagcuggac     1200

aacaccgugg ucggccagac gagcuggaag ccgaucucca accagagcug ggaccagaag     1260

uucacccugg agcucgaccg gucccgcgag cuggagauca gcguguacug gcgggacugg     1320

cgcucccugu gcgccgugaa guuccugcgg cucgaggacu uccuggacaa ccagcgccac     1380

gggaugugcc uguaccucga gccccagggc acccuguucg ccgaggucac cuucuucaac     1440

cccgugaucg agcggcgccc caagcugcag cggcagaaga agaucuucag caagcagcag     1500

gggaagacgu uccuccgcgc gccgcagaug aacaucaaca ucgccaccug gggccggcug     1560

guccgccggg ccauccccac cgugaaccac uccggcaccu ucagccccca ggcccccgug     1620

ccgacgaccg uccccguggu ggacguccgc aucccccagc uggcgccccc ggccuccgac     1680

agcaccguga ccaagcucga cuucgaccug gagcccgagc ccccgcccgc cccgccccgg     1740

gccuccagcc ugggggagau cgacgagucc agcgagcucc gcgugcugga cauccccggc     1800

caggacuccg agacggucuu cgacauccag aacgaccgga acagcauccu gcccaagucc     1860

cagagcgagu acaagcccga cacgccccag agcgggcucg aguacuccgg cauccaggag     1920

cuggaggacc gccggagcca gcagcgcuuc caguucaacc ugcaggacuu ccgcugcugc     1980

gccgugcucg ggcggggcca cuucggcaag gugcugcugg cggaguacaa gaacaccaac     2040

gagauguucg ccaucaaggc ccucaagaag ggggacaucg ucgcccgcga cgagguggac     2100

ucccugaugu gcgagaagcg gaucuucgag accgugaaca gcguccgcca cccguuccug     2160

gugaaccucu ucgccugcuu ccagaccaag gagcacgugu gcuucgucau ggaguacgcg     2220

gccggcgggg accugaugau gcacauccac accgacgugu ucuccgagcc ccgggccgug     2280

uucuacgccg ccugcgucgu gcugggccuc caguaccugc acgagcacaa gaucguguac     2340

cgcgaccuga agcucgacaa ccugcugcuc gacaccgagg gguucgucaa gaucgcggac     2400

uucggccugu gcaaggaggg caugggguac ggcgaccgga ccagcaccuu cugcgggacg     2460

cccgaguucc uggcccccga ggugcucacc gagaccuccu acacccgcgc cguggacugg     2520

uggggccugg ggguccugau cuacgagaug cucgugggcg agagcccguu ccccggcgac     2580

gacgaggagg agguguucga cuccaucguc aacgacgagg ugcgguaccc ccgcuuccug     2640

agcacggagg ccaucuccau caugcggcgc cugcuccggc gcaaccccga gcggcgccug     2700

ggggccagcg agaaggacgc ggaggacgug aagaagcacc cguucuuccg gcugaucgac     2760

ugguccgccc ucauggacaa gaaggucaag ccgcccuuca uccccaccau ccgcggccgg     2820

gaggacguga gcaacuucga cgacgaguuc accuccgagg cccccauccu gaccccgccc     2880

cgcgagcccc ggauccugag cgaggaggag caggagaugu uccgcgacuu cgacuacauc     2940

gccgacuggu gcuga                                                      2955


<210>  9266
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PKN2__Homo_sapiens__AAB33346

<400>  9266
auggccucca accccgagcg cggcgagauc cuccucaccg agcuccaggg cgacucccgc       60

ucccuccccu ucuccgagaa cgucuccgcc guccagaagc ucgacuucuc cgacaccaug      120

guccagcaga agcucgacga caucaaggac cgcaucaagc gcgagauccg caaggagcuc      180

aagaucaagg agggcgccga gaaccuccgc aaggucacca ccgacaagaa gucccucgcc      240

uacgucgaca acauccucaa gaaguccaac aagaagcucg aggagcucca ccacaagcuc      300

caggagcuca acgcccacau cgucgucucc gaccccgagg acaucaccga cugcccccgc      360

acccccgaca cccccaacaa cgacccccgc ugcuccaccu ccaacaaccg ccucaaggcc      420

cuccagaagc agcucgacau cgagcucaag gucaagcagg gcgccgagaa caugauccag      480

auguacucca acggcuccuc caaggaccgc aagcuccacg gcaccgccca gcagcuccuc      540

caggacucca agaccaagau cgaggucauc cgcaugcaga uccuccaggc cguccagacc      600

aacgagcucg ccuucgacaa cgccaagccc gucaucuccc cccucgagcu ccgcauggag      660

gagcuccgcc accacuuccg caucgaguuc gccgucgccg agggcgccaa gaacgucaug      720

aagcuccucg gcuccggcaa ggucaccgac cgcaaggccc ucuccgaggc ccaggcccgc      780

uucaacgagu ccucccagaa gcucgaccuc cucaaguacu cccucgagca gcgccucaac      840

gaggucccca agaaccaccc caagucccgc aucaucaucg aggagcucuc ccucgucgcc      900

gccuccccca cccucucccc ccgccagucc augaucucca cccagaacca guacuccacc      960

cucuccaagc ccgccgcccu caccggcacc cucgaggucc gccucauggg cugccaggac     1020

auccucgaga acguccccgg ccgcuccaag gccaccuccg ucgcccuccc cggcuggucc     1080

cccuccgaga cccgcuccuc cuucaugucc cgcaccucca aguccaaguc cggcuccucc     1140

cgcaaccucc ucaagaccga cgaccucucc aacgacgucu gcgccguccu caagcucgac     1200

aacaccgucg ucggccagac cuccuggaag cccaucucca accaguccug ggaccagaag     1260

uucacccucg agcucgaccg cucccgcgag cucgagaucu ccgucuacug gcgcgacugg     1320

cgcucccucu gcgccgucaa guuccuccgc cucgaggacu uccucgacaa ccagcgccac     1380

ggcaugugcc ucuaccucga gccccagggc acccucuucg ccgaggucac cuucuucaac     1440

cccgucaucg agcgccgccc caagcuccag cgccagaaga agaucuucuc caagcagcag     1500

ggcaagaccu uccuccgcgc cccccagaug aacaucaaca ucgccaccug gggccgccuc     1560

guccgccgcg ccauccccac cgucaaccac uccggcaccu ucucccccca ggcccccguc     1620

cccaccaccg uccccgucgu cgacguccgc aucccccagc ucgccccccc cgccuccgac     1680

uccaccguca ccaagcucga cuucgaccuc gagcccgagc ccccccccgc ccccccccgc     1740

gccuccuccc ucggcgagau cgacgagucc uccgagcucc gcguccucga cauccccggc     1800

caggacuccg agaccgucuu cgacauccag aacgaccgca acuccauccu ccccaagucc     1860

caguccgagu acaagcccga caccccccag uccggccucg aguacuccgg cauccaggag     1920

cucgaggacc gccgcuccca gcagcgcuuc caguucaacc uccaggacuu ccgcugcugc     1980

gccguccucg gccgcggcca cuucggcaag guccuccucg ccgaguacaa gaacaccaac     2040

gagauguucg ccaucaaggc ccucaagaag ggcgacaucg ucgcccgcga cgaggucgac     2100

ucccucaugu gcgagaagcg caucuucgag accgucaacu ccguccgcca ccccuuccuc     2160

gucaaccucu ucgccugcuu ccagaccaag gagcacgucu gcuucgucau ggaguacgcc     2220

gccggcggcg accucaugau gcacauccac accgacgucu ucuccgagcc ccgcgccguc     2280

uucuacgccg ccugcgucgu ccucggccuc caguaccucc acgagcacaa gaucgucuac     2340

cgcgaccuca agcucgacaa ccuccuccuc gacaccgagg gcuucgucaa gaucgccgac     2400

uucggccucu gcaaggaggg caugggcuac ggcgaccgca ccuccaccuu cugcggcacc     2460

cccgaguucc ucgcccccga gguccucacc gagaccuccu acacccgcgc cgucgacugg     2520

uggggccucg gcguccucau cuacgagaug cucgucggcg agucccccuu ccccggcgac     2580

gacgaggagg aggucuucga cuccaucguc aacgacgagg uccgcuaccc ccgcuuccuc     2640

uccaccgagg ccaucuccau caugcgccgc cuccuccgcc gcaaccccga gcgccgccuc     2700

ggcgccuccg agaaggacgc cgaggacguc aagaagcacc ccuucuuccg ccucaucgac     2760

ugguccgccc ucauggacaa gaaggucaag ccccccuuca uccccaccau ccgcggccgc     2820

gaggacgucu ccaacuucga cgacgaguuc accuccgagg cccccauccu cacccccccc     2880

cgcgagcccc gcauccucuc cgaggaggag caggagaugu uccgcgacuu cgacuacauc     2940

gccgacuggu gcuga                                                      2955


<210>  9267
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PKN2__Homo_sapiens__AAB33346

<400>  9267
auggccagca accccgagag aggcgaaauc cugcucaccg agcuucaggg ggacuccagg       60

ucucugccuu ucucagaaaa ugugagugcu guccaaaagu uggauuuuag cgacacaaug      120

guucagcaga aauuagauga cauuaaggau cggauaaaac gcgagauccg aaaggaacug      180

aaaauuaagg agggagcaga gaaccuacgu aaggugacua cggacaaaaa gucccucgcc      240

uacguagaua auauccugaa aaagucuaac aaaaagcugg aggaacuuca ccauaaguug      300

caggaacuca augcgcacau uguggucucg gacccagagg auaucaccga cugcccgaga      360

acacccgaua cuccuaacaa ugacccaagg uguucaacca gcaacaaucg gcugaaagcu      420

cugcaaaagc agcucgauau agaguuaaaa gugaagcagg gugccgaaaa caugauccag      480

auguauagua auggcuccuc uaaagaccgc aagcugcaug ggacagcaca acagcuuuug      540

caggacagca aaaccaagau ugagguuauc agaaugcaga uucugcaagc cgugcagacu      600

aacgaacuag cuuucgauaa ugcaaagccc gucaucuccc cucucgagcu gaggauggag      660

gaacuucggc accauuuucg cauagaguuc gccguggcug aaggagccaa aaacguaaug      720

aagcuguugg gcucagguaa aguuacagac cgaaaggcgc ucagugaggc acaggccaga      780

uuuaaugaaa gcucucaaaa acuggauuua cugaaguacu cccucgagca gaggcuuaac      840

gaagugccaa agaaccaccc caaaucacgg auuaucauug aggagcugag cuuggucgcu      900

gccaguccua cccuaucucc acgucagucc augaucagca cgcagaauca auauucgacu      960

cugucuaagc cggcagcucu caccgggaca cuggaagugc gccuuauggg augccaggac     1020

auccuggaga acgugcccgg cagauccaaa gccacuucag ucgcguugcc uggcuggagu     1080

ccaagcgaaa ccagguccuc uuucaugagc cggacaucaa agaguaaauc cgggagcucu     1140

cgaaaucucc ugaagaccga ugacuuauca aacgauguuu gugccgugcu gaagcuagac     1200

aauacgguag ugggacagac uuccuggaaa cccauuagca accaguccug ggaucaaaag     1260

uuuacacucg agcuggaccg cucuagagaa cuugagauau cggucuacug gagggauugg     1320

cggagcuugu gcgcagugaa auuccugcgc cucgaggacu uucuggacaa ucagagacac     1380

gguauguguc uuuaucugga accucagggc accuuguucg cugagguuac auuuuucaac     1440

ccagugaucg aaaggcgucc caagcuccag cggcagaaaa agauuuuuag uaagcaacag     1500

gggaaaacuu uccugcgagc cccgcagaug aauaucaaca uagcuaccug gggaagauua     1560

gucaggcgcg ccauuccuac ggugaaucau ucaggcaccu ucagucccca agcaccagua     1620

ccuacaacug uucccguggu cgaugugcgg aucccacagc uggcuccccc ugccucugac     1680

agcaccguca caaagcuaga uuuugaccuc gagccagagc cgcccccugc gccacccaga     1740

gcauccucac ugggugaaau cgaugagagc ucugaacuua ggguguugga cauuccuggg     1800

caggauuccg agacuguuuu cgacauccaa aacgaucgca auaguauucu gccaaaaagc     1860

cagucugaau acaagcccga caccccgcag uccggacucg aguauucagg cauacaggag     1920

cuggaagauc gacggaguca acagcguuuu caguucaacu uacaggacuu uagaugcugu     1980

gccgugcugg gcagggggca cuucggaaaa guacuuuugg cugaguacaa gaauacaaac     2040

gaaauguuug ccaucaaagc acucaagaag ggugauauug ucgcccgcga cgagguggac     2100

agccugaugu gcgaaaaacg gaucuucgag accguuaacu cggugagaca uccuuuucua     2160

gucaaucugu ucgcuuguuu ucaaacuaag gagcacgugu gcuucguaau ggaauacgcc     2220

gcaggcgggg aucucaugau gcacauccau acggacgugu uuuccgagcc aagggcgguu     2280

uucuaugcug ccugugucgu gcugggacuu caguacuugc acgaacauaa aauuguguau     2340

cgagaucuga aguuagacaa ccuccugcuu gauacagagg gcuucgucaa aauagcagac     2400

uuuggucugu gcaaggaagg gaugggcuac ggagaucgca ccucuacuuu cugcggcacc     2460

cccgaguuuu uggccccuga gguucucaca gaaaccagcu auacucgggc uguggacugg     2520

ugggggcugg gagugcuaau cuacgagaug cugguaggug aaucacccuu cccaggcgau     2580

gacgaggagg aagucuuuga uaguauugug aaugacgagg uuagauaucc uagguuccuc     2640

uccacagaag ccaucucuau uaugcgucgc cugcuucgga gaaaccccga gaggcgauug     2700

ggggcaagcg aaaaggaugc ugaggacgug aaaaagcacc cauuuuuccg gcugaucgac     2760

ugguccgccu uaauggauaa aaaggucaaa ccgccuuuua uacccacgau ccgcggaaga     2820

gaggacgugu caaauuucga ugacgaauuu accagcgagg cgccaauucu cacucccccu     2880

agggaaccac ggauccugag ugaggaggaa caggagaugu uccgagauuu ugacuacauu     2940

gccgauuggu guuga                                                      2955


<210>  9268
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PKN2__Homo_sapiens__AAB33346

<400>  9268
auggccagca accccgagag aggcgagauc cugcugaccg agcugcaggg cgacagcaga       60

agccugcccu ucagcgagaa cgugagcgcc gugcagaagc uggacuucag cgacaccaug      120

gugcagcaga agcuggacga caucaaggac agaaucaaga gagagaucag aaaggagcug      180

aagaucaagg agggcgccga gaaccugaga aaggugacca ccgacaagaa gagccuggcc      240

uacguggaca acauccugaa gaagagcaac aagaagcugg aggagcugca ccacaagcug      300

caggagcuga acgcccacau cguggugagc gaccccgagg acaucaccga cugccccaga      360

acccccgaca cccccaacaa cgaccccaga ugcagcacca gcaacaacag acugaaggcc      420

cugcagaagc agcuggacau cgagcugaag gugaagcagg gcgccgagaa caugauccag      480

auguacagca acggcagcag caaggacaga aagcugcacg gcaccgccca gcagcugcug      540

caggacagca agaccaagau cgaggugauc agaaugcaga uccugcaggc cgugcagacc      600

aacgagcugg ccuucgacaa cgccaagccc gugaucagcc cccuggagcu gagaauggag      660

gagcugagac accacuucag aaucgaguuc gccguggccg agggcgccaa gaacgugaug      720

aagcugcugg gcagcggcaa ggugaccgac agaaaggccc ugagcgaggc ccaggccaga      780

uucaacgaga gcagccagaa gcuggaccug cugaaguaca gccuggagca gagacugaac      840

gaggugccca agaaccaccc caagagcaga aucaucaucg aggagcugag ccugguggcc      900

gccagcccca cccugagccc cagacagagc augaucagca cccagaacca guacagcacc      960

cugagcaagc ccgccgcccu gaccggcacc cuggagguga gacugauggg cugccaggac     1020

auccuggaga acgugcccgg cagaagcaag gccaccagcg uggcccugcc cggcuggagc     1080

cccagcgaga ccagaagcag cuucaugagc agaaccagca agagcaagag cggcagcagc     1140

agaaaccugc ugaagaccga cgaccugagc aacgacgugu gcgccgugcu gaagcuggac     1200

aacaccgugg ugggccagac cagcuggaag cccaucagca accagagcug ggaccagaag     1260

uucacccugg agcuggacag aagcagagag cuggagauca gcguguacug gagagacugg     1320

agaagccugu gcgccgugaa guuccugaga cuggaggacu uccuggacaa ccagagacac     1380

ggcaugugcc uguaccugga gccccagggc acccuguucg ccgaggugac cuucuucaac     1440

cccgugaucg agagaagacc caagcugcag agacagaaga agaucuucag caagcagcag     1500

ggcaagaccu uccugagagc cccccagaug aacaucaaca ucgccaccug gggcagacug     1560

gugagaagag ccauccccac cgugaaccac agcggcaccu ucagccccca ggcccccgug     1620

cccaccaccg ugcccguggu ggacgugaga aucccccagc uggccccccc cgccagcgac     1680

agcaccguga ccaagcugga cuucgaccug gagcccgagc ccccccccgc cccccccaga     1740

gccagcagcc ugggcgagau cgacgagagc agcgagcuga gagugcugga cauccccggc     1800

caggacagcg agaccguguu cgacauccag aacgacagaa acagcauccu gcccaagagc     1860

cagagcgagu acaagcccga caccccccag agcggccugg aguacagcgg cauccaggag     1920

cuggaggaca gaagaagcca gcagagauuc caguucaacc ugcaggacuu cagaugcugc     1980

gccgugcugg gcagaggcca cuucggcaag gugcugcugg ccgaguacaa gaacaccaac     2040

gagauguucg ccaucaaggc ccugaagaag ggcgacaucg uggccagaga cgagguggac     2100

agccugaugu gcgagaagag aaucuucgag accgugaaca gcgugagaca ccccuuccug     2160

gugaaccugu ucgccugcuu ccagaccaag gagcacgugu gcuucgugau ggaguacgcc     2220

gccggcggcg accugaugau gcacauccac accgacgugu ucagcgagcc cagagccgug     2280

uucuacgccg ccugcguggu gcugggccug caguaccugc acgagcacaa gaucguguac     2340

agagaccuga agcuggacaa ccugcugcug gacaccgagg gcuucgugaa gaucgccgac     2400

uucggccugu gcaaggaggg caugggcuac ggcgacagaa ccagcaccuu cugcggcacc     2460

cccgaguucc uggcccccga ggugcugacc gagaccagcu acaccagagc cguggacugg     2520

uggggccugg gcgugcugau cuacgagaug cuggugggcg agagccccuu ccccggcgac     2580

gacgaggagg agguguucga cagcaucgug aacgacgagg ugagauaccc cagauuccug     2640

agcaccgagg ccaucagcau caugagaaga cugcugagaa gaaaccccga gagaagacug     2700

ggcgccagcg agaaggacgc cgaggacgug aagaagcacc ccuucuucag acugaucgac     2760

uggagcgccc ugauggacaa gaaggugaag ccccccuuca uccccaccau cagaggcaga     2820

gaggacguga gcaacuucga cgacgaguuc accagcgagg cccccauccu gacccccccc     2880

agagagccca gaauccugag cgaggaggag caggagaugu ucagagacuu cgacuacauc     2940

gccgacuggu gcuga                                                      2955


<210>  9269
<211>  2955
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PKN2__Homo_sapiens__AAB33346

<400>  9269
auggccagca accccgagag aggcgaaauc cugcucaccg agcugcaggg ggacucccgg       60

ucucuuccuu ucagcgaaaa uguguccgcu guccaaaagc uggauuuuuc ugacacaaug      120

guucagcaga aacucgauga cauuaaggau cgcaucaaaa gagagauucg gaaggaacug      180

aaaaucaagg agggagccga gaaccuucgc aaggugacga ccgacaaaaa gagccuggcg      240

uacguggaua auauucucaa aaaguccaac aaaaagcugg aggaacugca ccauaagcuc      300

caggaacuga augcucacau cgucgugucu gacccggagg auaucacaga cugccccaga      360

accccugaua cacccaacaa ugacccucgg uguagcaccu ccaacaaucg ccuuaaagcc      420

cugcaaaagc agcucgauau ugagcugaaa guuaagcagg gcgccgaaaa caugauccag      480

auguauagca augggucuuc caaagacaga aaacuucaug gaacagcuca acagcugcuc      540

caggacagca aaaccaagau ugaggugauc cggaugcaga uucugcaagc cguccagacg      600

aacgaacugg cuuucgauaa ugccaagccc gugaucucuc cucucgagcu gcgcauggag      660

gaacuuagac accauuuucg gauugaguuc gcgguugccg aaggcgcuaa aaacgugaug      720

aagcugcucg gguccggaaa agucaccgac cgcaaggccc ugagcgaggc ucaggccaga      780

uuuaaugaau cuucccaaaa acuugaucug cucaaguaca gccuggagca gcggcugaac      840

gaagugccga agaaccaccc caaaucccgc aucaucauug aggagcucuc ucugguggcg      900

gccagcccua cacuuucccc cagacagagc augaucucua cccagaauca auauuccaca      960

cugagcaagc cugcugcccu caccggcacg cuggaagucc ggcuuauggg cugccaggac     1020

auucuggaga acguucccgg gagaucuaaa gcuacaagcg uggcccuccc gggauggucc     1080

ccuucugaaa cccgcagcuc cuucaugagc cggacaucua aguccaaaag cgggucuucc     1140

agaaaucugc ugaagaccga ugaccucagc aacgaugugu gugccguccu gaaacuugac     1200

aauaccgugg uuggccagac auccuggaag cccaucucua accagagcug ggaucaaaag     1260

uuuacgcugg agcucgaccg cucccgggaa cuggagauuu cuguguacug gagagauugg     1320

cgcagccugu gcgcugucaa auuccuucgg cucgaggacu uucuggacaa ucagagacac     1380

ggaauguguc uguaucucga accucagggc acccuguucg cggaggugac auuuuucaac     1440

cccguuaucg aacgccggcc caaacuucag agacaaaaga agaucuuuuc caagcagcag     1500

gggaagaccu uccugcgcgc cccucagaug aauauuaaca ucgcuacaug gggacggcuc     1560

gugagacggg ccauuccgac cgucaaucau agcggcacgu ucucucccca agccccugug     1620

cccacaaccg ucccuguggu ugaugugcgc aucccccagc uggcuccgcc ugccuccgac     1680

agcaccguca caaagcugga uuuugaccuu gagcccgagc cucccccugc gcccccgaga     1740

gcuucuuccc ucggcgaaau ugaugagagc ucugaacugc gggugcugga caucccuggg     1800

caggauagcg agaccguuuu cgacauccaa aacgauagaa auuccauucu ccccaaaagc     1860

cagucugaau acaagcccga cacaccucag uccggacugg aguauagcgg cauccaggag     1920

cuugaagauc gccgguccca acagagauuu caguucaacc ugcaggacuu ucgcugcugu     1980

gccgugcucg ggagaggaca cuucggcaaa guccugcugg ccgaguacaa gaauacgaac     2040

gaaauguuug cuauuaaagc ccuuaagaag ggggauaucg uggcucggga cgagguggac     2100

ucucucaugu gcgaaaaacg cauuuucgag accguuaaca gcgucagaca uccguuucug     2160

gugaaucugu ucgccuguuu ucaaacaaag gagcacgugu gcuucgucau ggaauacgcg     2220

gccggaggcg aucucaugau gcacauccau accgacgugu uuuccgagcc ccgggcuguu     2280

uucuaugccg cuuguguggu ccugggccuu caguaccugc acgaacauaa aauuguguau     2340

cgcgaucuca agcuggacaa ccugcuucuc gauacagagg gguucguuaa aaucgccgac     2400

uuuggacugu gcaaggaagg caugggguac ggagauagaa ccucuacguu cugcggcacc     2460

ccugaguuuc uggcgcccga ggugcucaca gaaaccagcu auacacgggc cgucgacugg     2520

ugggggcugg gcgugcuuau cuacgagaug cugguuggag aauccccuuu ccccggcgau     2580

gacgaggagg aaguguuuga uucuauuguc aaugacgagg ugcgcuaucc uagauuccuc     2640

agcaccgaag cuaucuccau uaugcggcgc cugcugagac ggaaccccga gagacgccuu     2700

ggggccagcg aaaaggaugc ugaggacgug aaaaagcacc cguuuuuccg gcugaucgac     2760

uggucugccc ucauggauaa aaaggucaaa ccucccuuua uuccuacgau cagaggacgc     2820

gaggacguuu ccaauuucga ugacgaauuu acaagcgagg cccccauccu gaccccgccu     2880

cgggaacccc gcauucucuc ugaggaggaa caggagaugu ucagagauuu ugacuacauc     2940

gcugauuggu guuga                                                      2955


<210>  9270
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PKN3__Homo_sapiens__Q6P5Z2

<400>  9270

Met Glu Glu Gly Ala Pro Arg Gln Pro Gly Pro Ser Gln Trp Pro Pro 
1               5                   10                  15      


Glu Asp Glu Lys Glu Val Ile Arg Arg Ala Ile Gln Lys Glu Leu Lys 
            20                  25                  30          


Ile Lys Glu Gly Val Glu Asn Leu Arg Arg Val Ala Thr Asp Arg Arg 
        35                  40                  45              


His Leu Gly His Val Gln Gln Leu Leu Arg Ser Ser Asn Arg Arg Leu 
    50                  55                  60                  


Glu Gln Leu His Gly Glu Leu Arg Glu Leu His Ala Arg Ile Leu Leu 
65                  70                  75                  80  


Pro Gly Pro Gly Pro Gly Pro Ala Glu Pro Val Ala Ser Gly Pro Arg 
                85                  90                  95      


Pro Trp Ala Glu Gln Leu Arg Ala Arg His Leu Glu Ala Leu Arg Arg 
            100                 105                 110         


Gln Leu His Val Glu Leu Lys Val Lys Gln Gly Ala Glu Asn Met Thr 
        115                 120                 125             


His Thr Cys Ala Ser Gly Thr Pro Lys Glu Arg Lys Leu Leu Ala Ala 
    130                 135                 140                 


Ala Gln Gln Met Leu Arg Asp Ser Gln Leu Lys Val Ala Leu Leu Arg 
145                 150                 155                 160 


Met Lys Ile Ser Ser Leu Glu Ala Ser Gly Ser Pro Glu Pro Gly Pro 
                165                 170                 175     


Glu Leu Leu Ala Glu Glu Leu Gln His Arg Leu His Val Glu Ala Ala 
            180                 185                 190         


Val Ala Glu Gly Ala Lys Asn Val Val Lys Leu Leu Ser Ser Arg Arg 
        195                 200                 205             


Thr Gln Asp Arg Lys Ala Leu Ala Glu Ala Gln Ala Gln Leu Gln Glu 
    210                 215                 220                 


Ser Ser Gln Lys Leu Asp Leu Leu Arg Leu Ala Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Glu Gln Leu Pro Pro Ala His Pro Leu Arg Ser Arg Val Thr Arg Glu 
                245                 250                 255     


Leu Arg Ala Ala Val Pro Gly Tyr Pro Gln Pro Ser Gly Thr Pro Val 
            260                 265                 270         


Lys Pro Thr Ala Leu Thr Gly Thr Leu Gln Val Arg Leu Leu Gly Cys 
        275                 280                 285             


Glu Gln Leu Leu Thr Ala Val Pro Gly Arg Ser Pro Ala Ala Ala Leu 
    290                 295                 300                 


Ala Ser Ser Pro Ser Glu Gly Trp Leu Arg Thr Lys Ala Lys His Gln 
305                 310                 315                 320 


Arg Gly Arg Gly Glu Leu Ala Ser Glu Val Leu Ala Val Leu Lys Val 
                325                 330                 335     


Asp Asn Arg Val Val Gly Gln Thr Gly Trp Gly Gln Val Ala Glu Gln 
            340                 345                 350         


Ser Trp Asp Gln Thr Phe Val Ile Pro Leu Glu Arg Ala Arg Glu Leu 
        355                 360                 365             


Glu Ile Gly Val His Trp Arg Asp Trp Arg Gln Leu Cys Gly Val Ala 
    370                 375                 380                 


Phe Leu Arg Leu Glu Asp Phe Leu Asp Asn Ala Cys His Gln Leu Ser 
385                 390                 395                 400 


Leu Ser Leu Val Pro Gln Gly Leu Leu Phe Ala Gln Val Thr Phe Cys 
                405                 410                 415     


Asp Pro Val Ile Glu Arg Arg Pro Arg Leu Gln Arg Gln Glu Arg Ile 
            420                 425                 430         


Phe Ser Lys Arg Arg Gly Gln Asp Phe Leu Arg Ala Ser Gln Met Asn 
        435                 440                 445             


Leu Gly Met Ala Ala Trp Gly Arg Leu Val Met Asn Leu Leu Pro Pro 
    450                 455                 460                 


Cys Ser Ser Pro Ser Thr Ile Ser Pro Pro Lys Gly Cys Pro Arg Thr 
465                 470                 475                 480 


Pro Thr Thr Leu Arg Glu Ala Ser Asp Pro Ala Thr Pro Ser Asn Phe 
                485                 490                 495     


Leu Pro Lys Lys Thr Pro Leu Gly Glu Glu Met Thr Pro Pro Pro Lys 
            500                 505                 510         


Pro Pro Arg Leu Tyr Leu Pro Gln Glu Pro Thr Ser Glu Glu Thr Pro 
        515                 520                 525             


Arg Thr Lys Arg Pro His Met Glu Pro Arg Thr Arg Arg Gly Pro Ser 
    530                 535                 540                 


Pro Pro Ala Ser Pro Thr Arg Lys Pro Pro Arg Leu Gln Asp Phe Arg 
545                 550                 555                 560 


Cys Leu Ala Val Leu Gly Arg Gly His Phe Gly Lys Val Leu Leu Val 
                565                 570                 575     


Gln Phe Lys Gly Thr Gly Lys Tyr Tyr Ala Ile Lys Ala Leu Lys Lys 
            580                 585                 590         


Gln Glu Val Leu Ser Arg Asp Glu Ile Glu Ser Leu Tyr Cys Glu Lys 
        595                 600                 605             


Arg Ile Leu Glu Ala Val Gly Cys Thr Gly His Pro Phe Leu Leu Ser 
    610                 615                 620                 


Leu Leu Ala Cys Phe Gln Thr Ser Ser His Ala Cys Phe Val Thr Glu 
625                 630                 635                 640 


Phe Val Pro Gly Gly Asp Leu Met Met Gln Ile His Glu Asp Val Phe 
                645                 650                 655     


Pro Glu Pro Gln Ala Arg Phe Tyr Val Ala Cys Val Val Leu Gly Leu 
            660                 665                 670         


Gln Phe Leu His Glu Lys Lys Ile Ile Tyr Arg Asp Leu Lys Leu Asp 
        675                 680                 685             


Asn Leu Leu Leu Asp Ala Gln Gly Phe Leu Lys Ile Ala Asp Phe Gly 
    690                 695                 700                 


Leu Cys Lys Glu Gly Ile Gly Phe Gly Asp Arg Thr Ser Thr Phe Cys 
705                 710                 715                 720 


Gly Thr Pro Glu Phe Leu Ala Pro Glu Val Leu Thr Gln Glu Ala Tyr 
                725                 730                 735     


Thr Arg Ala Val Asp Trp Trp Gly Leu Gly Val Leu Leu Tyr Glu Met 
            740                 745                 750         


Leu Val Gly Glu Cys Pro Phe Pro Gly Asp Thr Glu Glu Glu Val Phe 
        755                 760                 765             


Asp Cys Ile Val Asn Met Asp Ala Pro Tyr Pro Gly Phe Leu Ser Val 
    770                 775                 780                 


Gln Gly Leu Glu Phe Ile Gln Lys Leu Leu Gln Lys Cys Pro Glu Lys 
785                 790                 795                 800 


Arg Leu Gly Ala Gly Glu Gln Asp Ala Glu Glu Ile Lys Val Gln Pro 
                805                 810                 815     


Phe Phe Arg Thr Thr Asn Trp Gln Ala Leu Leu Ala Arg Thr Ile Gln 
            820                 825                 830         


Pro Pro Phe Val Pro Thr Leu Cys Gly Pro Ala Asp Leu Arg Tyr Phe 
        835                 840                 845             


Glu Gly Glu Phe Thr Gly Leu Pro Pro Ala Leu Thr Pro Pro Ala Pro 
    850                 855                 860                 


His Ser Leu Leu Thr Ala Arg Gln Gln Ala Ala Phe Arg Asp Phe Asp 
865                 870                 875                 880 


Phe Val Ser Glu Arg Phe Leu Glu Pro 
                885                 


<210>  9271
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PKN3__Homo_sapiens__AAH62558

<400>  9271
auggaggagg gggcgccgcg gcagccuggg ccgagccagu ggcccccaga ggaugagaag       60

gaggugaucc gccgggccau ccagaaagag cugaagauca aggagggggu ggagaaccug      120

cggcgcgugg ccacagaccg ccgccacuug ggccaugugc agcagcugcu gcgguccucc      180

aaccgccgcc uggagcagcu gcauggcgag cugcgggagc ugcacgcccg aauccugcug      240

cccggcccug ggccuggccc agcugagccu guggccucag gaccccggcc gugggcagag      300

cagcucaggg cucggcaccu agaggcucuc cggaggcagc ugcaugugga gcugaaggug      360

aagcaggggg cugagaacau gacccacacg ugcgccagug gcacccccaa ggagaggaag      420

cuccuggcag cugcccagca gaugcugcgg gacagccagc ugaagguggc ccugcugcgg      480

augaagauca gcagccugga ggccaguggg uccccggagc cagggccuga gcugcuggcg      540

gaggagcuac agcaucgacu gcacguugag gcagcugugg cugagggcgc caagaacgug      600

gugaaacugc uuaguagccg gagaacacag gaccgcaagg cacuggcuga ggcccaggcc      660

cagcuacagg aguccucuca gaaacuggac cuccugcgcc uggccuugga gcagcugcug      720

gagcaacugc cuccugccca cccuuugcgc agcagaguga cccgagaguu gcgggcugcg      780

gugccuggau acccccagcc uucagggaca ccugugaagc ccaccgcccu aacagggaca      840

cugcaggucc gccuccuggg cugugaacag uugcugacag ccgugccugg gcgcucccca      900

gcggccgcac uggccagcag ccccuccgag ggcuggcuuc ggaccaaggc caagcaccag      960

cguggccgag gcgagcuugc cagcgaggug cuggcugugc uaaaggugga caaccguguu     1020

guggggcaga cgggcugggg gcagguggcc gaacaguccu gggaccagac cuuugucauc     1080

ccacuggagc gagcccguga gcuggagauu gggguacacu ggcgggacug gcggcagcua     1140

uguggcgugg ccuuccugag acuugaggac uuccuggaca augccuguca ccaacugucc     1200

cucagccugg uaccgcaggg acugcuuuuu gcccagguga ccuucugcga uccugucauu     1260

gagaggcggc cccggcugca gaggcaggaa cgcaucuucu cuaaacgcag aggccaggac     1320

uuccugaggg cuucgcagau gaaccucggc auggcggccu gggggcgccu cgucaugaac     1380

cugcugcccc ccugcagcuc cccgagcaca aucagccccc cuaaaggaug cccucggacc     1440

ccaacaacac ugcgagaggc cucugacccu gccacuccca guaauuuccu gcccaagaag     1500

acccccuugg gugaagagau gacaccccca cccaagcccc cacgccucua ccucccccag     1560

gagccaacau ccgaggagac uccgcgcacc aaacgucccc auauggagcc uaggacucga     1620

cgugggccau cuccaccagc cucccccacc aggaaacccc cucggcuuca ggacuuccgc     1680

ugcuuagcug ugcugggccg gggacacuuu gggaaggucc uccuggucca guucaagggg     1740

acagggaaau acuacgccau caaagcacug aagaagcagg aggugcucag ccgggacgag     1800

auagagagcc uguacugcga gaagcggauc cuggaggcug ugggcugcac agggcacccu     1860

uuccugcucu cccuccuugc cugcuuccag accuccagcc augccugcuu ugugacugag     1920

uuugugccug guggugaccu caugaugcag auccacgagg augucuuccc cgagccccag     1980

gcccgcuucu acguggcuug uguuguccug gggcugcagu ucuuacacga gaagaagauc     2040

auuuacaggg accugaaguu ggauaaccuu cugcuggaug cccagggauu ccugaagauc     2100

gcagacuuug gacucugcaa ggaagggauc ggcuucgggg accggacuag caccuucugu     2160

ggcaccccgg aguuccuggc ucccgaggug cugacccagg aggcauacac acgggcugug     2220

gacugguggg ggcugggugu gcugcucuac gagaugcugg ugggugagug cccguuccca     2280

ggggacacag aggaagaggu guuugacugc aucgucaaca uggacgcccc cuaccccggc     2340

uuucugucgg ugcaagggcu ugaguucauu cagaagcucc uccagaagug cccggagaag     2400

cgccucgggg caggugagca ggaugccgag gagaucaagg uccagccauu cuucaggacc     2460

accaacuggc aagcccugcu cgcccgcacc auccagcccc ccuucgugcc uacccugugu     2520

ggcccugcgg accugcgcua cuuugagggc gaguucacag ggcugccgcc ugcccugacc     2580

ccaccugcac cccacagccu ccucacugcc cgccaacagg ccgccuuccg ggacuucgac     2640

uuugugucag agcgauuccu ggaacccuga                                      2670


<210>  9272
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PKN3__Homo_sapiens__AAH62558

<400>  9272
auggaggagg gcgcgccccg ccagccgggg cccagccagu ggccgcccga ggacgagaag       60

gaggugaucc ggcgcgccau ccagaaggag cugaagauca aggagggcgu cgagaaccuc      120

cggcgcgugg ccaccgaccg gcgccaccug gggcacgugc agcagcugcu ccgguccagc      180

aaccgccggc uggagcagcu gcacggcgag cuccgcgagc ugcacgcccg gauccugcuc      240

ccggggcccg gccccggccc cgccgagccg gucgccuccg ggccccgccc cugggccgag      300

cagcugcggg cgcgccaccu ggaggcccuc cggcgccagc ugcacgugga gcugaaggug      360

aagcagggcg ccgagaacau gacccacacg ugcgccagcg ggacccccaa ggagcggaag      420

cuccuggcgg ccgcccagca gaugcugcgc gacucccagc ucaaggucgc ccugcugcgg      480

augaagauca gcucccucga ggccagcggc uccccggagc ccgggcccga gcugcuggcg      540

gaggagcucc agcaccgccu gcacguggag gccgccgugg ccgagggcgc caagaacguc      600

gugaagcugc ucagcucccg gcgcacccag gaccgcaagg cgcuggccga ggcccaggcc      660

cagcugcagg agagcuccca gaagcucgac cugcugcggc ucgcccugga gcagcugcuc      720

gagcagcugc ccccggcgca cccccugcgc agccggguga cccgcgagcu ccgggccgcc      780

guccccggcu acccccagcc guccgggacg cccgugaagc ccaccgcccu gaccggcacc      840

cuccaggugc gccuccuggg gugcgagcag cugcucacgg ccguccccgg ccggagcccg      900

gcggccgccc uggccuccag ccccuccgag ggcuggcugc gcaccaaggc gaagcaccag      960

cgggggcgcg gcgagcucgc cagcgaggug cuggccgugc ugaaggucga caaccgggug     1020

guggggcaga ccggcugggg gcaggucgcc gagcagagcu gggaccagac cuucgugauc     1080

ccccuggagc gcgcccggga gcucgagauc ggcgugcacu ggcgcgacug gcggcagcug     1140

ugcggcgucg cguuccugcg ccucgaggac uuccuggaca acgccugcca ccagcugucc     1200

cucagccugg ugccccaggg gcuccucuuc gcccagguca cguucugcga cccggugauc     1260

gagcggcgcc cccggcugca gcgccaggag cgcaucuucu ccaagcggcg cggccaggac     1320

uuccugcggg ccagccagau gaaccucggg auggccgcgu ggggccgccu ggugaugaac     1380

cugcugcccc cgugcuccag ccccuccacc aucagcccgc ccaaggggug cccccggacc     1440

cccaccacgc ugcgcgaggc cuccgacccc gccaccccca gcaacuuccu gccgaagaag     1500

acgccccucg gcgaggagau gaccccgccg cccaagccgc cccggcugua ccugccccag     1560

gagcccaccu ccgaggagac gccccgcacc aagcggcccc acauggagcc ccgcacccgg     1620

cgcggcccca gcccgcccgc cucccccacc cggaagccgc cccgccucca ggacuuccgg     1680

ugccuggccg uccuggggcg cggccacuuc gggaaggugc uccuggugca guucaagggc     1740

accgggaagu acuacgcgau caaggcccug aagaagcagg agguccucag ccgggacgag     1800

aucgaguccc uguacugcga gaagcgcauc cuggaggccg ugggcugcac cggccacccc     1860

uuccuccuga gccugcucgc cugcuuccag accuccagcc acgcgugcuu cgugacggag     1920

uucguccccg ggggcgaccu gaugaugcag auccacgagg acguguuccc cgagccccag     1980

gcccgguucu acguggccug cgucgugcug gggcuccagu uccugcacga gaagaagauc     2040

aucuaccgcg accugaagcu cgacaaccug cugcucgacg cccagggcuu ccugaagauc     2100

gccgacuucg gccugugcaa ggaggggauc ggcuucgggg accggaccuc caccuucugc     2160

ggcacccccg aguuccucgc gcccgaggug cugacgcagg aggccuacac ccgcgccguc     2220

gacugguggg ggcugggcgu gcuccuguac gagaugcugg ugggcgagug ccccuucccc     2280

ggggacaccg aggaggaggu cuucgacugc aucgugaaca uggacgcccc cuacccgggc     2340

uuccucagcg ugcaggggcu ggaguucauc cagaagcugc uccagaagug ccccgagaag     2400

cgccugggcg ccggggagca ggacgcggag gagaucaagg uccagcccuu cuuccggacc     2460

acgaacuggc aggcccugcu cgcccgcacc auccagcccc cguucgugcc cacccugugc     2520

ggccccgccg accugcggua cuucgagggc gaguucaccg ggcugccccc ggcccugacc     2580

ccgcccgcgc cccacagccu gcucacggcc cgccagcagg ccgccuuccg ggacuucgac     2640

uucguguccg agcgcuuccu ggagcccuga                                      2670


<210>  9273
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PKN3__Homo_sapiens__AAH62558

<400>  9273
auggaggagg gcgccccccg ccagcccggc cccucccagu ggccccccga ggacgagaag       60

gaggucaucc gccgcgccau ccagaaggag cucaagauca aggagggcgu cgagaaccuc      120

cgccgcgucg ccaccgaccg ccgccaccuc ggccacgucc agcagcuccu ccgcuccucc      180

aaccgccgcc ucgagcagcu ccacggcgag cuccgcgagc uccacgcccg cauccuccuc      240

cccggccccg gccccggccc cgccgagccc gucgccuccg gcccccgccc cugggccgag      300

cagcuccgcg cccgccaccu cgaggcccuc cgccgccagc uccacgucga gcucaagguc      360

aagcagggcg ccgagaacau gacccacacc ugcgccuccg gcacccccaa ggagcgcaag      420

cuccucgccg ccgcccagca gaugcuccgc gacucccagc ucaaggucgc ccuccuccgc      480

augaagaucu ccucccucga ggccuccggc ucccccgagc ccggccccga gcuccucgcc      540

gaggagcucc agcaccgccu ccacgucgag gccgccgucg ccgagggcgc caagaacguc      600

gucaagcucc ucuccucccg ccgcacccag gaccgcaagg cccucgccga ggcccaggcc      660

cagcuccagg aguccuccca gaagcucgac cuccuccgcc ucgcccucga gcagcuccuc      720

gagcagcucc cccccgccca cccccuccgc ucccgcguca cccgcgagcu ccgcgccgcc      780

guccccggcu acccccagcc cuccggcacc cccgucaagc ccaccgcccu caccggcacc      840

cuccaggucc gccuccucgg cugcgagcag cuccucaccg ccguccccgg ccgcuccccc      900

gccgccgccc ucgccuccuc ccccuccgag ggcuggcucc gcaccaaggc caagcaccag      960

cgcggccgcg gcgagcucgc cuccgagguc cucgccgucc ucaaggucga caaccgcguc     1020

gucggccaga ccggcugggg ccaggucgcc gagcaguccu gggaccagac cuucgucauc     1080

ccccucgagc gcgcccgcga gcucgagauc ggcguccacu ggcgcgacug gcgccagcuc     1140

ugcggcgucg ccuuccuccg ccucgaggac uuccucgaca acgccugcca ccagcucucc     1200

cucucccucg ucccccaggg ccuccucuuc gcccagguca ccuucugcga ccccgucauc     1260

gagcgccgcc cccgccucca gcgccaggag cgcaucuucu ccaagcgccg cggccaggac     1320

uuccuccgcg ccucccagau gaaccucggc auggccgccu ggggccgccu cgucaugaac     1380

cuccuccccc ccugcuccuc ccccuccacc aucucccccc ccaagggcug cccccgcacc     1440

cccaccaccc uccgcgaggc cuccgacccc gccacccccu ccaacuuccu ccccaagaag     1500

accccccucg gcgaggagau gacccccccc cccaagcccc cccgccucua ccucccccag     1560

gagcccaccu ccgaggagac cccccgcacc aagcgccccc acauggagcc ccgcacccgc     1620

cgcggccccu ccccccccgc cucccccacc cgcaagcccc cccgccucca ggacuuccgc     1680

ugccucgccg uccucggccg cggccacuuc ggcaaggucc uccucgucca guucaagggc     1740

accggcaagu acuacgccau caaggcccuc aagaagcagg agguccucuc ccgcgacgag     1800

aucgaguccc ucuacugcga gaagcgcauc cucgaggccg ucggcugcac cggccacccc     1860

uuccuccucu cccuccucgc cugcuuccag accuccuccc acgccugcuu cgucaccgag     1920

uucguccccg gcggcgaccu caugaugcag auccacgagg acgucuuccc cgagccccag     1980

gcccgcuucu acgucgccug cgucguccuc ggccuccagu uccuccacga gaagaagauc     2040

aucuaccgcg accucaagcu cgacaaccuc cuccucgacg cccagggcuu ccucaagauc     2100

gccgacuucg gccucugcaa ggagggcauc ggcuucggcg accgcaccuc caccuucugc     2160

ggcacccccg aguuccucgc ccccgagguc cucacccagg aggccuacac ccgcgccguc     2220

gacugguggg gccucggcgu ccuccucuac gagaugcucg ucggcgagug ccccuucccc     2280

ggcgacaccg aggaggaggu cuucgacugc aucgucaaca uggacgcccc cuaccccggc     2340

uuccucuccg uccagggccu cgaguucauc cagaagcucc uccagaagug ccccgagaag     2400

cgccucggcg ccggcgagca ggacgccgag gagaucaagg uccagcccuu cuuccgcacc     2460

accaacuggc aggcccuccu cgcccgcacc auccagcccc ccuucguccc cacccucugc     2520

ggccccgccg accuccgcua cuucgagggc gaguucaccg gccucccccc cgcccucacc     2580

ccccccgccc cccacucccu ccucaccgcc cgccagcagg ccgccuuccg cgacuucgac     2640

uucgucuccg agcgcuuccu cgagcccuga                                      2670


<210>  9274
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PKN3__Homo_sapiens__AAH62558

<400>  9274
auggaggaag gcgcccccag acagccuggg ccaagccaau ggccgcccga ggacgaaaag       60

gaggugauca ggcgggcuau ucagaaagaa cugaagauaa aagagggagu cgagaaccuc      120

cgccgaguug caaccgaucg uagacaccuu ggucaugugc agcagcuguu gagguccucu      180

aaucggcgcu uagaacaacu gcacggcgag cuaagagaac uccaugccag gauccugcuu      240

ccugggccag gacccggccc ugcggagcca guagcuucag guccccggcc uugggccgag      300

cagcugcgcg cacgacacuu ggaagcccuc agaaggcagc ugcaugugga gcugaagguc      360

aaacaggggg cugaaaacau gacacacacu ugcgcaagug gaacgccaaa ggagcggaag      420

cucuuagccg cugcccaaca gaugcugcgu gacagccagc uuaaaguggc guugcugcgc      480

augaagauuu ccucucuaga agcaucgggc ucaccggagc ccggcccuga gcuccuggcc      540

gaagaguugc agcacagacu gcauguugaa gcugccgugg cagagggggc uaaaaauguc      600

gugaaguugc ucagcaguag gcggacccaa gaucgaaaag cccuggcgga agcccaggca      660

caguuacaag aguccucuca gaagcuggac cuccuucgcc uggcuuugga gcagcuacug      720

gaacagcucc cacccgccca cccucugaga agcaggguaa cacgggagcu ucgcgcugcc      780

guuccaggau acccccaacc guccgguacu ccugugaagc ccaccgcacu gacaggcacc      840

uugcagguca gacuccuggg gugugaacag uuacugacug ccgugccagg aagguccccu      900

gcugcggcac uagccaguag ccccucugag ggcuggcucc guacaaaagc uaagcaucag      960

cggggucgag gggaacuggc cuccgaggug cuugcagucu ugaaaguuga uaacagagug     1020

guaggacaaa ccggcugggg ccagguggcc gagcagucau gggaccagac guucgucauc     1080

ccacuggaaa gggcucgcga gcucgaaauu ggggugcacu ggcgggauug gagacaacug     1140

ugcggaguug ccuuucuuag gcuggaggac uucuuggaua augcauguca ccagcucagc     1200

cugaguuuag ugccccaggg ucugcuauuu gcgcagguca cuuucugcga cccugugauc     1260

gagcgccgac cacggcucca acgucaggaa agaauauuuu cuaagaggcg cggccaggau     1320

uuccugcggg cuucccaaau gaaccuuggg auggccgcau ggggaagauu gguaaugaau     1380

cugcucccgc ccuguagcuc gccuucuacc aucuccccac ccaaaggcug cccuaggaca     1440

ccaacuaccc ugcgagaggc cucagacccc gcuacaccga guaacuuuuu accuaagaaa     1500

accccacugg gugaagagau gacgcccccu cccaagccac cucgccuuua uuugccccag     1560

gaaccaacua gcgaggagac accgcggacc aagagaccuc auauggaacc caggacucgu     1620

cgcgggccau cacccccugc cucuccaaca cggaaacccc cuagacucca ggauuucagg     1680

ugucuggcag uucuaggccg aggacacuuu ggcaaggugc ugcucgucca guucaaaggg     1740

accggaaagu acuaugcuau uaaagcccug aagaagcaag aggugcuuag ccgggacgaa     1800

aucgagucau uguacugcga aaaacgcauu cuggaggcgg ucgguuguac gggccauccg     1860

uuuuuacuca gucugcuugc cugcuuccag accuccagcc acgcuuguuu ugugacagag     1920

uucguuccag ggggagaccu gaugaugcag auccaugaag auguguuccc cgagccucag     1980

gcaagauuuu auguagccug cgucguguug ggccuccaau uccugcacga aaagaaaaua     2040

auuuacaggg accuaaagcu ggauaaucuc cugcuugacg cucaggguuu ucuuaaaauc     2100

gccgauuucg ggcugugcaa ggagggcauu ggauuuggcg accggacuuc uaccuucugu     2160

gggacaccag aauuuuuagc acccgagguu cucacucagg aggcguauac ccgagccgug     2220

gauugguggg gacugggugu ccuucuguac gaaaugcuag ugggcgagug cccuuucccg     2280

ggggacacag aagaggaggu auuugauugu aucgugaaca uggacgcucc cuacccagga     2340

uuccucucag uucagggccu ggaauuuauc caaaaguugc ugcagaaaug cccugagaag     2400

agauuaggug ccggggaaca ggaugcagag gaaauuaaag uccaacccuu cuuucgcacc     2460

acuaauuggc aggcucuccu ggccaggacg auacagccac cuuucgugcc cacacuuugu     2520

ggcccagcag accugcguua uuucgaggga gaguuuaccg gcuugccgcc ugcccucacu     2580

cccccagcuc cccacagucu gcuaaccgcg cggcagcaag ccgcauucag agacuuugau     2640

uucgugagcg aaagguuucu ggagccuuga                                      2670


<210>  9275
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PKN3__Homo_sapiens__AAH62558

<400>  9275
auggaggagg gcgcccccag acagcccggc cccagccagu ggccccccga ggacgagaag       60

gaggugauca gaagagccau ccagaaggag cugaagauca aggagggcgu ggagaaccug      120

agaagagugg ccaccgacag aagacaccug ggccacgugc agcagcugcu gagaagcagc      180

aacagaagac uggagcagcu gcacggcgag cugagagagc ugcacgccag aauccugcug      240

cccggccccg gccccggccc cgccgagccc guggccagcg gccccagacc cugggccgag      300

cagcugagag ccagacaccu ggaggcccug agaagacagc ugcacgugga gcugaaggug      360

aagcagggcg ccgagaacau gacccacacc ugcgccagcg gcacccccaa ggagagaaag      420

cugcuggccg ccgcccagca gaugcugaga gacagccagc ugaagguggc ccugcugaga      480

augaagauca gcagccugga ggccagcggc agccccgagc ccggccccga gcugcuggcc      540

gaggagcugc agcacagacu gcacguggag gccgccgugg ccgagggcgc caagaacgug      600

gugaagcugc ugagcagcag aagaacccag gacagaaagg cccuggccga ggcccaggcc      660

cagcugcagg agagcagcca gaagcuggac cugcugagac uggcccugga gcagcugcug      720

gagcagcugc cccccgccca cccccugaga agcagaguga ccagagagcu gagagccgcc      780

gugcccggcu acccccagcc cagcggcacc cccgugaagc ccaccgcccu gaccggcacc      840

cugcagguga gacugcuggg cugcgagcag cugcugaccg ccgugcccgg cagaagcccc      900

gccgccgccc uggccagcag ccccagcgag ggcuggcuga gaaccaaggc caagcaccag      960

agaggcagag gcgagcuggc cagcgaggug cuggccgugc ugaaggugga caacagagug     1020

gugggccaga ccggcugggg ccagguggcc gagcagagcu gggaccagac cuucgugauc     1080

ccccuggaga gagccagaga gcuggagauc ggcgugcacu ggagagacug gagacagcug     1140

ugcggcgugg ccuuccugag acuggaggac uuccuggaca acgccugcca ccagcugagc     1200

cugagccugg ugccccaggg ccugcuguuc gcccagguga ccuucugcga ccccgugauc     1260

gagagaagac ccagacugca gagacaggag agaaucuuca gcaagagaag aggccaggac     1320

uuccugagag ccagccagau gaaccugggc auggccgccu ggggcagacu ggugaugaac     1380

cugcugcccc ccugcagcag ccccagcacc aucagccccc ccaagggcug ccccagaacc     1440

cccaccaccc ugagagaggc cagcgacccc gccaccccca gcaacuuccu gcccaagaag     1500

accccccugg gcgaggagau gacccccccc cccaagcccc ccagacugua ccugccccag     1560

gagcccacca gcgaggagac ccccagaacc aagagacccc acauggagcc cagaaccaga     1620

agaggcccca gcccccccgc cagccccacc agaaagcccc ccagacugca ggacuucaga     1680

ugccuggccg ugcugggcag aggccacuuc ggcaaggugc ugcuggugca guucaagggc     1740

accggcaagu acuacgccau caaggcccug aagaagcagg aggugcugag cagagacgag     1800

aucgagagcc uguacugcga gaagagaauc cuggaggccg ugggcugcac cggccacccc     1860

uuccugcuga gccugcuggc cugcuuccag accagcagcc acgccugcuu cgugaccgag     1920

uucgugcccg gcggcgaccu gaugaugcag auccacgagg acguguuccc cgagccccag     1980

gccagauucu acguggccug cguggugcug ggccugcagu uccugcacga gaagaagauc     2040

aucuacagag accugaagcu ggacaaccug cugcuggacg cccagggcuu ccugaagauc     2100

gccgacuucg gccugugcaa ggagggcauc ggcuucggcg acagaaccag caccuucugc     2160

ggcacccccg aguuccuggc ccccgaggug cugacccagg aggccuacac cagagccgug     2220

gacugguggg gccugggcgu gcugcuguac gagaugcugg ugggcgagug ccccuucccc     2280

ggcgacaccg aggaggaggu guucgacugc aucgugaaca uggacgcccc cuaccccggc     2340

uuccugagcg ugcagggccu ggaguucauc cagaagcugc ugcagaagug ccccgagaag     2400

agacugggcg ccggcgagca ggacgccgag gagaucaagg ugcagcccuu cuucagaacc     2460

accaacuggc aggcccugcu ggccagaacc auccagcccc ccuucgugcc cacccugugc     2520

ggccccgccg accugagaua cuucgagggc gaguucaccg gccugccccc cgcccugacc     2580

ccccccgccc cccacagccu gcugaccgcc agacagcagg ccgccuucag agacuucgac     2640

uucgugagcg agagauuccu ggagcccuga                                      2670


<210>  9276
<211>  2670
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PKN3__Homo_sapiens__AAH62558

<400>  9276
auggaggaag gcgcccccag acagccuggg ccgagccaau ggcccccuga ggacgaaaag       60

gaggugaucc ggcgcgcuau ucagaaagaa cugaagauca aagagggagu cgagaaccuc      120

agacggguug ccaccgaucg cagacaccug ggccaugugc agcagcuucu gcgguccucu      180

aaucgcagac ucgaacaacu gcacggggag cuucgggaac ugcaugcgcg cauucuccug      240

cccggaccug gccccgggcc ugcugagccg guggccagcg gacccagacc uugggccgag      300

cagcugcggg cucgccaccu cgaagcccug agacggcagc uucaugucga gcugaaggug      360

aaacagggcg cugaaaacau gacacacacg ugcgccuccg gcacccccaa ggagcgcaag      420

cuccuggcgg ccgcucaaca gaugcuuaga gacucucagc ugaaaguugc ccuccugcgg      480

augaagauca gcucccugga agccucuggg agcccugagc ccggaccgga gcuccuggcc      540

gaggaacuuc agcacagacu gcauguggaa gcggccgucg cugagggcgc caaaaaugug      600

guuaagcucc uguccagccg ccggacacaa gauagaaaag cucuugccga agcccaggcu      660

cagcugcaag agucuuccca gaagcucgac cugcugcgcc ucgcgcugga gcagcuucug      720

gaacagcucc cucccgccca cccucugcgg agcagaguga cccgcgagcu ucgggcugcc      780

guccccgggu acccccaacc uucuggaaca ccggugaagc ccaccgcccu gacaggcacc      840

cuccagguga gacugcuggg gugugaacag cuccugacgg cugucccugg acgcuccccc      900

gccgcggcuc uugccagcuc uccuuccgag ggcuggcugc ggaccaaagc caagcaucag      960

agaggccgcg gggaacucgc uagcgagguu cuggccgugc ugaaagugga uaaccggguc     1020

gugggacaaa caggcugggg gcagguugcu gagcaguccu gggaccagac cuucgugauu     1080

ccccuugaaa gagcccggga gcucgaaauc ggaguccacu ggcgcgauug gagacaacug     1140

ugcggcgugg cguuucugcg gcucgaggac uuccuggaua augccuguca ccagcuuucu     1200

cugagccucg uuccgcaggg gcugcuguuu gcucagguga cauucugcga cccugucauc     1260

gagagacgcc cccggcuuca aagacaggaa cgcaucuuuu ccaagagacg gggacaggau     1320

uuccuccgcg ccagccaaau gaaccugggc auggcugccu ggggcagacu ggugaugaau     1380

cuccugccuc ccuguucuuc cccuagcacc auuucucccc cgaaagggug cccucggacg     1440

cccacaaccc uucgcgaggc gagcgacccc gccacaccuu ccaacuuucu gccgaagaaa     1500

acaccccucg gagaagagau gaccccuccc ccuaagcccc cuagacugua ucugccccag     1560

gaaccgaccu cugaggagac gccucggacc aagcgccccc auauggaacc uagaacacgg     1620

cgcggcccca gcccgccugc uucccccacc agaaaaccuc cccggcuuca ggauuucaga     1680

ugucucgccg uccuggggcg cggacacuuu ggcaaggugc ugcucguuca guucaaaggg     1740

acaggcaagu acuaugcuau uaaagcccug aagaagcaag aggugcuuag ccgggacgaa     1800

aucgagucuc uguacugcga aaaacgcauu cucgaggccg ucggauguac cggccauccc     1860

uuucugcugu cccuucucgc uugcuuccag acgagcucuc acgcguguuu ugugacagag     1920

uucguuccug ggggagaccu gaugaugcag auccaugaag auguguuccc ggagccccag     1980

gccagauuuu augucgcuug cguggugcug ggccuccaau uccugcacga aaagaaaauu     2040

aucuaccggg accuuaagcu ggauaaucuc cugcuggacg cccagggguu ucuuaaaauc     2100

gccgauuucg gacugugcaa ggagggcauu ggguuuggcg acagaaccuc caccuucugu     2160

ggaacaccug aauuucucgc ucccgagguu cugacccagg aggccuauac acgcgcgguc     2220

gauugguggg gccucggggu gcugcuuuac gaaaugcugg ugggagagug cccuuucccc     2280

ggcgacacgg aagaggaggu cuuugauugu aucgugaaca uggacgcucc uuacccgggg     2340

uuccucagcg uucagggacu ggaauuuauu caaaagcugc uucagaaaug ccccgagaag     2400

cggcugggcg ccggggaaca ggaugccgag gaaaucaaag ugcaaccuuu cuuuagaacc     2460

acaaauuggc aggcucuccu ggcccgcacc auucagcccc cuuucguccc cacacucugu     2520

ggcccggcgg accugcggua uuucgaggga gaguuuaccg gccuuccucc cgcucugacg     2580

cccccugcuc cccacucccu ccugaccgcc agacagcaag cugccuuccg ggacuuugau     2640

uucgugucug aacgcuuucu ggagccuuga                                      2670


<210>  9277
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRKCA__Homo_sapiens__P17252

<400>  9277

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         






<210>  9278
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRKCA__Homo_sapiens__CCDS11664.1

<400>  9278
auggcugacg uuuucccggg caacgacucc acggcgucuc aggacguggc caaccgcuuc       60

gcccgcaaag gggcgcugag gcagaagaac gugcacgagg ugaaggacca caaauucauc      120

gcgcgcuucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggguuu      180

gggaaacaag gcuuccagug ccaaguuugc uguuuugugg uccacaagag gugccaugaa      240

uuuguuacuu uuucuugucc gggugcggau aagggacccg acacugauga ccccaggagc      300

aagcacaagu ucaaaaucca cacuuacgga agccccaccu ucugcgauca cuguggguca      360

cugcucuaug gacuuaucca ucaagggaug aaaugugaca ccugcgauau gaacguucac      420

aagcaaugcg ucaucaaugu ccccagccuc ugcggaaugg aucacacuga gaagaggggg      480

cggauuuacc uaaaggcuga gguugcugau gaaaagcucc augucacagu acgagaugca      540

aaaaaucuaa ucccuaugga uccaaacggg cuuucagauc cuuaugugaa gcugaaacuu      600

auuccugauc ccaagaauga aagcaagcaa aaaaccaaaa ccauccgcuc cacacuaaau      660

ccgcagugga augaguccuu uacauucaaa uugaaaccuu cagacaaaga ccgacgacug      720

ucuguagaaa ucugggacug ggaucgaaca acaaggaaug acuucauggg aucccuuucc      780

uuuggaguuu cggagcugau gaagaugccg gccaguggau gguacaaguu gcuuaaccaa      840

gaagaaggug aguacuacaa cguacccauu ccggaagggg acgaggaagg aaacauggaa      900

cucaggcaga aauucgagaa agccaaacuu ggcccugcug gcaacaaagu caucaguccc      960

ucugaagaca ggaaacaacc uuccaacaac cuugaccgag ugaaacucac ggacuucaau     1020

uuccucaugg uguugggaaa ggggaguuuu ggaaagguga ugcuugccga caggaagggc     1080

acagaagaac uguaugcaau caaaauccug aagaaggaug uggugauuca ggaugaugac     1140

guggagugca ccaugguaga aaagcgaguc uuggcccugc uugacaaacc cccguucuug     1200

acgcagcugc acuccugcuu ccagacagug gaucggcugu acuucgucau ggaauauguc     1260

aacggugggg accucaugua ccacauucag caaguaggaa aauuuaagga accacaagca     1320

guauucuaug cggcagagau uuccaucgga uuguucuuuc uucauaaaag aggaaucauu     1380

uauagggauc ugaaguuaga uaacgucaug uuggauucag aaggacauau caaaauugcu     1440

gacuuuggga ugugcaagga acacaugaug gauggaguca cgaccaggac cuucuguggg     1500

acuccagauu auaucgcccc agagauaauc gcuuaucagc cguauggaaa aucuguggac     1560

uggugggccu auggcguccu guuguaugaa augcuugccg ggcagccucc auuugauggu     1620

gaagaugaag acgagcuauu ucagucuauc auggagcaca acguuuccua uccaaaaucc     1680

uuguccaagg aggcuguuuc ugucugcaaa ggacugauga ccaaacaccc agccaagcgg     1740

cugggcugug ggccugaggg ggagagggac gugagagagc augccuucuu ccggaggauc     1800

gacugggaaa aacuggagaa cagggagauc cagccaccau ucaagcccaa aguguguggc     1860

aaaggagcag agaacuuuga caaguucuuc acacgaggac agcccgucuu aacaccaccu     1920

gaucagcugg uuauugcuaa cauagaccag ucugauuuug aaggguucuc guaugucaac     1980

ccccaguuug ugcaccccau cuuacagagu gcaguauga                            2019


<210>  9279
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRKCA__Homo_sapiens__CCDS11664.1

<400>  9279
auggccgacg uguuccccgg caacgacagc accgccuccc aggacgucgc gaaccgcuuc       60

gcccggaagg gggcccugcg ccagaagaac gugcacgagg ugaaggacca caaguucauc      120

gcccgguucu ucaagcagcc gaccuucugc agccacugca ccgacuucau cuggggcuuc      180

gggaagcagg gcuuccagug ccaggucugc ugcuucgugg ugcacaagcg cugccacgag      240

uucgucaccu ucuccugccc cggggccgac aagggccccg acaccgacga cccccggagc      300

aagcacaagu ucaagaucca caccuacggc uccccgacgu ucugcgacca cugcgggagc      360

cuccuguacg gccugaucca ccaggggaug aagugcgaca cgugcgacau gaacgugcac      420

aagcagugcg ugaucaacgu ccccucccuc ugcggcaugg accacaccga gaagcgcggg      480

cggaucuacc ugaaggcgga gguggccgac gagaagcugc acgugaccgu ccgcgacgcc      540

aagaaccuca uccccaugga ccccaacggc cugagcgacc cguacgugaa gcugaagcuc      600

auccccgacc ccaagaacga guccaagcag aagaccaaga ccauccggag cacccugaac      660

ccccagugga acgaguccuu caccuucaag cugaagccga gcgacaagga ccgccggcuc      720

uccguggaga ucugggacug ggaccgcacg acccggaacg acuucauggg cagccugucc      780

uucgggguca gcgagcugau gaagaugccc gccuccggcu gguacaagcu ccugaaccag      840

gaggaggggg aguacuacaa cgugcccauc cccgagggcg acgaggaggg caacauggag      900

cugcgccaga aguucgagaa ggcgaagcuc gggccggccg gcaacaaggu gaucagcccc      960

uccgaggacc ggaagcagcc cagcaacaac cuggaccgcg ucaagcugac cgacuucaac     1020

uuccucaugg ugcuggggaa gggcagcuuc gggaagguga ugcuggccga ccggaagggc     1080

accgaggagc ucuacgccau caagauccug aagaaggacg ucgugaucca ggacgacgac     1140

guggagugca cgauggucga gaagcgcgug cuggcccucc uggacaagcc cccguuccug     1200

acccagcucc acuccugcuu ccagaccguc gaccggcugu acuucgugau ggaguacgug     1260

aacggcgggg accugaugua ccacauccag caggucggca aguucaagga gccccaggcg     1320

guguucuacg ccgccgagau cagcaucggc cucuucuucc ugcacaagcg cgggaucauc     1380

uaccgggacc ugaagcucga caacgugaug cuggacuccg aggggcacau caagaucgcc     1440

gacuucggca ugugcaagga gcacaugaug gacggcguca ccacgcgcac cuucugcggg     1500

acccccgacu acaucgcccc cgagaucauc gcguaccagc cguacggcaa gagcguggac     1560

uggugggccu acggggugcu gcucuacgag augcuggccg gccagccgcc cuucgacggg     1620

gaggacgagg acgagcuguu ccaguccauc auggagcaca acgucagcua ccccaagucc     1680

cucagcaagg aggccguguc cgugugcaag ggccugauga ccaagcaccc cgccaagcgc     1740

cugggcugcg ggcccgaggg cgagcgggac guccgcgagc acgcguucuu ccggcgcauc     1800

gacugggaga agcucgagaa ccgggagauc cagcccccgu ucaagcccaa ggugugcggg     1860

aagggcgccg agaacuucga caaguucuuc acgcgcggcc agcccgugcu gacgcccccg     1920

gaccagcugg ucaucgccaa caucgaccag agcgacuucg agggguucuc cuacgugaac     1980

ccccaguucg ugcaccccau ccuccagagc gccgucuga                            2019


<210>  9280
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRKCA__Homo_sapiens__CCDS11664.1

<400>  9280
auggccgacg ucuuccccgg caacgacucc accgccuccc aggacgucgc caaccgcuuc       60

gcccgcaagg gcgcccuccg ccagaagaac guccacgagg ucaaggacca caaguucauc      120

gcccgcuucu ucaagcagcc caccuucugc ucccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggucugc ugcuucgucg uccacaagcg cugccacgag      240

uucgucaccu ucuccugccc cggcgccgac aagggccccg acaccgacga cccccgcucc      300

aagcacaagu ucaagaucca caccuacggc ucccccaccu ucugcgacca cugcggcucc      360

cuccucuacg gccucaucca ccagggcaug aagugcgaca ccugcgacau gaacguccac      420

aagcagugcg ucaucaacgu ccccucccuc ugcggcaugg accacaccga gaagcgcggc      480

cgcaucuacc ucaaggccga ggucgccgac gagaagcucc acgucaccgu ccgcgacgcc      540

aagaaccuca uccccaugga ccccaacggc cucuccgacc ccuacgucaa gcucaagcuc      600

auccccgacc ccaagaacga guccaagcag aagaccaaga ccauccgcuc cacccucaac      660

ccccagugga acgaguccuu caccuucaag cucaagcccu ccgacaagga ccgccgccuc      720

uccgucgaga ucugggacug ggaccgcacc acccgcaacg acuucauggg cucccucucc      780

uucggcgucu ccgagcucau gaagaugccc gccuccggcu gguacaagcu ccucaaccag      840

gaggagggcg aguacuacaa cguccccauc cccgagggcg acgaggaggg caacauggag      900

cuccgccaga aguucgagaa ggccaagcuc ggccccgccg gcaacaaggu caucuccccc      960

uccgaggacc gcaagcagcc cuccaacaac cucgaccgcg ucaagcucac cgacuucaac     1020

uuccucaugg uccucggcaa gggcuccuuc ggcaagguca ugcucgccga ccgcaagggc     1080

accgaggagc ucuacgccau caagauccuc aagaaggacg ucgucaucca ggacgacgac     1140

gucgagugca ccauggucga gaagcgcguc cucgcccucc ucgacaagcc ccccuuccuc     1200

acccagcucc acuccugcuu ccagaccguc gaccgccucu acuucgucau ggaguacguc     1260

aacggcggcg accucaugua ccacauccag caggucggca aguucaagga gccccaggcc     1320

gucuucuacg ccgccgagau cuccaucggc cucuucuucc uccacaagcg cggcaucauc     1380

uaccgcgacc ucaagcucga caacgucaug cucgacuccg agggccacau caagaucgcc     1440

gacuucggca ugugcaagga gcacaugaug gacggcguca ccacccgcac cuucugcggc     1500

acccccgacu acaucgcccc cgagaucauc gccuaccagc ccuacggcaa guccgucgac     1560

uggugggccu acggcguccu ccucuacgag augcucgccg gccagccccc cuucgacggc     1620

gaggacgagg acgagcucuu ccaguccauc auggagcaca acgucuccua ccccaagucc     1680

cucuccaagg aggccgucuc cgucugcaag ggccucauga ccaagcaccc cgccaagcgc     1740

cucggcugcg gccccgaggg cgagcgcgac guccgcgagc acgccuucuu ccgccgcauc     1800

gacugggaga agcucgagaa ccgcgagauc cagccccccu ucaagcccaa ggucugcggc     1860

aagggcgccg agaacuucga caaguucuuc acccgcggcc agcccguccu cacccccccc     1920

gaccagcucg ucaucgccaa caucgaccag uccgacuucg agggcuucuc cuacgucaac     1980

ccccaguucg uccaccccau ccuccagucc gccgucuga                            2019


<210>  9281
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRKCA__Homo_sapiens__CCDS11664.1

<400>  9281
auggccgacg uguuccccgg caacgauagc accgcuuccc aggacgucgc aaauagauuu       60

gccaggaagg gggcgcugcg gcaaaagaac guucacgagg ugaaggauca uaaauucauc      120

gcucgcuuuu ucaagcagcc uaccuuuugc ucucacugua cugacuucau uuggggauuu      180

gguaaacagg gcuuccagug ccaaguaugu ugcuuugugg uccauaagcg augucacgag      240

uucgugacgu uuucaugccc aggggccgau aagggaccgg acaccgauga cccccguagu      300

aaacauaagu ucaaaauaca cacauacggc agcccuacuu uuugugauca cugcgguucc      360

cuccuuuaug ggcugaucca ucagggaaug aagugugaua ccugcgacau gaauguucac      420

aaacagugug ugauuaacgu cccaucuuug ugcggcaugg accauacaga aaagagaggc      480

aggaucuacu uaaaggcaga aguggccgau gagaaacugc acguaaccgu ucgggacgcu      540

aagaaucuaa uucccaugga cccuaacggg cucucggauc cauaugugaa acugaaacuu      600

auccccgacc cuaaaaauga aucaaagcag aaaacuaaga caauacgcag cacccugaac      660

ccacaaugga augagaguuu cacguucaag uugaaaccgu ccgauaagga cagaaggcuc      720

ucugucgaga ucugggauug ggaccggacu acccgcaacg auuuuauggg aagccugucc      780

uucggugugu cagaacugau gaaaaugccc gcaaguggcu gguacaagcu cuuaaaucag      840

gaggaagggg aguauuacaa cgugccuauu ccagagggag acgaagaggg caauauggaa      900

cugcgacaga aauuugagaa ggccaaacuu ggucccgcug ggaacaaggu caucagcccu      960

ucugaagaua gaaagcagcc auccaauaac uuggacaggg uuaaacugac agauuucaac     1020

uuucuaaugg ugcucggaaa gggcucauuc ggcaaaguaa ugcuggccga ccggaagggg     1080

acugaggagc uuuaugcgau uaagauccug aaaaaggacg uggucauaca agaugacgau     1140

guggaaugca ccaugguuga gaaacgugug uuggcacucc uggacaagcc cccguuuuua     1200

acacagcugc acagcuguuu ccagaccguc gaucgccucu acuuugugau ggaauacgua     1260

aauggaggug accuuaugua ucauauucaa cagguuggca aauucaagga gccucaggcc     1320

guguuuuacg cugccgaaau caguauuggg cuguucuuuu ugcacaagag aggaaucauc     1380

uauagggauc uaaaacugga caacgucaug cucgauucug agggccauau uaagauagca     1440

gacuucggua ugugcaaaga gcacaugaug gaugggguga cgacucggac auucuguggc     1500

acccccgacu acaucgcucc agaaauuauc gccuaucagc cuuacggaaa guccgucgau     1560

uggugggcgu auggcgugcu gcuuuacgag augcuggccg ggcaaccccc auuugacgga     1620

gaagacgagg augaauuguu ccagagcaua auggagcaua auguuucgua ccccaaaucu     1680

cucuccaagg aggcaguguc aguaugcaaa ggucugauga cuaagcaccc ugcuaagcga     1740

uuaggcugug ggccagaagg agagcgcgac gucagagaac acgccuuuuu caggcggauu     1800

gauugggaga aacuggagaa ccgcgaaauc cagccgcccu uuaagccuaa agugugcggc     1860

aagggugcug agaauuucga caaauuuuuc acaagagggc agccaguucu aacacccccu     1920

gaucaacucg ugaucgccaa cauugaccag agugauuuug aaggcuucag cuaugucaau     1980

ccacaguuug ugcaucccau ccugcagucc gcaguauga                            2019


<210>  9282
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRKCA__Homo_sapiens__CCDS11664.1

<400>  9282
auggccgacg uguuccccgg caacgacagc accgccagcc aggacguggc caacagauuc       60

gccagaaagg gcgcccugag acagaagaac gugcacgagg ugaaggacca caaguucauc      120

gccagauucu ucaagcagcc caccuucugc agccacugca ccgacuucau cuggggcuuc      180

ggcaagcagg gcuuccagug ccaggugugc ugcuucgugg ugcacaagag augccacgag      240

uucgugaccu ucagcugccc cggcgccgac aagggccccg acaccgacga ccccagaagc      300

aagcacaagu ucaagaucca caccuacggc agccccaccu ucugcgacca cugcggcagc      360

cugcuguacg gccugaucca ccagggcaug aagugcgaca ccugcgacau gaacgugcac      420

aagcagugcg ugaucaacgu gcccagccug ugcggcaugg accacaccga gaagagaggc      480

agaaucuacc ugaaggccga gguggccgac gagaagcugc acgugaccgu gagagacgcc      540

aagaaccuga uccccaugga ccccaacggc cugagcgacc ccuacgugaa gcugaagcug      600

auccccgacc ccaagaacga gagcaagcag aagaccaaga ccaucagaag cacccugaac      660

ccccagugga acgagagcuu caccuucaag cugaagccca gcgacaagga cagaagacug      720

agcguggaga ucugggacug ggacagaacc accagaaacg acuucauggg cagccugagc      780

uucggcguga gcgagcugau gaagaugccc gccagcggcu gguacaagcu gcugaaccag      840

gaggagggcg aguacuacaa cgugcccauc cccgagggcg acgaggaggg caacauggag      900

cugagacaga aguucgagaa ggccaagcug ggccccgccg gcaacaaggu gaucagcccc      960

agcgaggaca gaaagcagcc cagcaacaac cuggacagag ugaagcugac cgacuucaac     1020

uuccugaugg ugcugggcaa gggcagcuuc ggcaagguga ugcuggccga cagaaagggc     1080

accgaggagc uguacgccau caagauccug aagaaggacg uggugaucca ggacgacgac     1140

guggagugca ccauggugga gaagagagug cuggcccugc uggacaagcc ccccuuccug     1200

acccagcugc acagcugcuu ccagaccgug gacagacugu acuucgugau ggaguacgug     1260

aacggcggcg accugaugua ccacauccag caggugggca aguucaagga gccccaggcc     1320

guguucuacg ccgccgagau cagcaucggc cuguucuucc ugcacaagag aggcaucauc     1380

uacagagacc ugaagcugga caacgugaug cuggacagcg agggccacau caagaucgcc     1440

gacuucggca ugugcaagga gcacaugaug gacggcguga ccaccagaac cuucugcggc     1500

acccccgacu acaucgcccc cgagaucauc gccuaccagc ccuacggcaa gagcguggac     1560

uggugggccu acggcgugcu gcuguacgag augcuggccg gccagccccc cuucgacggc     1620

gaggacgagg acgagcuguu ccagagcauc auggagcaca acgugagcua ccccaagagc     1680

cugagcaagg aggccgugag cgugugcaag ggccugauga ccaagcaccc cgccaagaga     1740

cugggcugcg gccccgaggg cgagagagac gugagagagc acgccuucuu cagaagaauc     1800

gacugggaga agcuggagaa cagagagauc cagccccccu ucaagcccaa ggugugcggc     1860

aagggcgccg agaacuucga caaguucuuc accagaggcc agcccgugcu gacccccccc     1920

gaccagcugg ugaucgccaa caucgaccag agcgacuucg agggcuucag cuacgugaac     1980

ccccaguucg ugcaccccau ccugcagagc gccguguga                            2019


<210>  9283
<211>  2019
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRKCA__Homo_sapiens__CCDS11664.1

<400>  9283
auggccgacg uguuccccgg caacgauagc accgcuuccc aggacgucgc caauagauuu       60

gcgcggaagg gggcucugcg ccagaaaaac guucacgagg ugaaggauca uaaauucauc      120

gccagauuuu ucaagcaacc uacauuuugc ucucacugua cggacuucau uuggggauuu      180

ggcaaacagg gguuccagug ccaagugugu ugcuuugucg ugcauaagcg gugucacgag      240

uucguuaccu uuagcugccc gggagccgau aagggccccg acacagauga cccucgcucc      300

aaacauaagu ucaaaaucca caccuacggg ucucccacau uuugugauca cugcggaagc      360

cuccuguaug gccuuauuca ucagggcaug aagugugaua ccugcgacau gaaugugcac      420

aaacagugug ucaucaacgu gccuucccug ugcgggaugg accauacaga aaagagagga      480

cggauuuacc ucaaggcuga aguugccgau gagaaacugc acgugaccgu ccgcgacgcu      540

aagaaucuua uccccaugga cccuaacggc cugucugauc cguaugugaa acucaagcug      600

auccccgacc cuaaaaauga aagcaagcag aaaacgaaga ccauuagauc cacacugaac      660

ccccaaugga augagagcuu caccuucaag cucaaaccuu cugauaagga ccggcgccug      720

uccguggaga ucugggauug ggacagaaca acccggaacg auuuuauggg gagccuuucu      780

uucggagucu ccgaacugau gaaaaugccc gccagcggcu gguacaagcu ccugaaucag      840

gaggaagggg aguauuacaa cguuccgauu ccugagggag acgaagaggg caauauggaa      900

cuucgccaga aauuugagaa ggcgaagcug ggccccgccg ggaacaaagu gaucucuccu      960

uccgaagaua gaaagcagcc cagcaauaac cucgaccggg ugaaacugac ggauuucaac     1020

uuucugaugg uccucggaaa gggcuccuuc gggaaaguga ugcuggcuga ccgcaaggga     1080

acagaggagc uuuaugccau uaagauccug aaaaaggacg uugugauuca agaugacgau     1140

gucgaaugca ccauggugga gaaaagaguu cucgcucugc uugacaagcc cccuuuucug     1200

acacagcucc acucuuguuu ccagaccgug gaucggcugu acuuugucau ggaauacgug     1260

aauggcgggg accugaugua ucauauccaa caggucggaa aauucaagga gccgcaggcc     1320

guguuuuacg cggccgaaau cagcauuggc cucuucuuuc ugcacaagag aggcaucauu     1380

uaucgcgauc uuaaacugga caacguuaug cucgauuccg aggggcauau caagauugcu     1440

gacuucggaa ugugcaaaga gcacaugaug gauggcguga ccacacggac guucuguggg     1500

acccccgacu acaucgcccc ugaaaucauu gcuuaucagc ccuacggaaa gagcgucgau     1560

uggugggccu auggcgugcu gcuuuacgag augcuggccg ggcaaccucc cuuugacggc     1620

gaagacgagg augaacucuu ccagucuauc auggagcaua auguuuccua cccgaaaagc     1680

cugucuaagg aggcugugag cgucugcaaa ggacugauga caaagcaccc ugcgaagaga     1740

cucggcugug ggcccgaagg agagcgcgac gugcgggaac acgccuuuuu cagacgcauu     1800

gauugggaga aacuggagaa ccgggaaauc cagccucccu uuaagccuaa agugugcggc     1860

aagggggcug agaauuucga caaauuuuuc accagaggac agcccguucu uacaccgccu     1920

gaucaacugg ucauugccaa caucgaccag uccgauuuug aaggcuucuc uuaugugaau     1980

ccccaguuug ugcaucccau ccuccagagc gccgucuga                            2019


<210>  9284
<211>  878
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  PRKD2__Homo_sapiens__NP_001073349.1

<400>  9284

Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly 
1               5                   10                  15      


Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro 
            20                  25                  30          


Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His 
        35                  40                  45              


Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser 
    50                  55                  60                  


Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys 
65                  70                  75                  80  


Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe 
                85                  90                  95      


Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser 
            100                 105                 110         


Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser 
        115                 120                 125             


Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His 
    130                 135                 140                 


Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe 
145                 150                 155                 160 


Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr 
                165                 170                 175     


His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg 
            180                 185                 190         


Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg 
        195                 200                 205             


Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met 
                245                 250                 255     


Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr 
            260                 265                 270         


Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu 
        275                 280                 285             


Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys 
    290                 295                 300                 


Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile 
305                 310                 315                 320 


Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp 
                325                 330                 335     


Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly 
            340                 345                 350         


Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu 
        355                 360                 365             


Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val 
    370                 375                 380                 


Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg 
385                 390                 395                 400 


Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg 
                405                 410                 415     


His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn 
            420                 425                 430         


Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr 
        435                 440                 445             


Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro 
    450                 455                 460                 


His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu 
465                 470                 475                 480 


Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala 
                485                 490                 495     


Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile 
            500                 505                 510         


Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala 
        515                 520                 525             


Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp 
    530                 535                 540                 


Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
545                 550                 555                 560 


Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
                565                 570                 575     


Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
            580                 585                 590         


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro 
        595                 600                 605             


Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe 
    610                 615                 620                 


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
625                 630                 635                 640 


Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr 
                645                 650                 655     


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
            660                 665                 670         


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
        675                 680                 685             


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
    690                 695                 700                 


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
705                 710                 715                 720 


Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
                725                 730                 735     


Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
            740                 745                 750         


Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
        755                 760                 765             


Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile 
    770                 775                 780                 


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
785                 790                 795                 800 


Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu 
                805                 810                 815     


Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser 
            820                 825                 830         


Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly 
        835                 840                 845             


Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln 
    850                 855                 860                 


Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu 
865                 870                 875             


<210>  9285
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  PRKD2__Homo_sapiens__CCDS12689.1

<400>  9285
auggccaccg cccccucuua ucccgccggg cucccuggcu cucccgggcc ggggucuccu       60

ccgccccccg gcggccuaga gcugcagucg ccgccaccgc uacugcccca gaucccggcc      120

ccggguuccg gggucuccuu ucacauccag aucgggcuga cccgcgaguu cgugcuguug      180

cccgccgccu ccgagcuggc ucaugugaag cagcuggccu guuccaucgu ggaccagaag      240

uucccugagu guggcuucua cggccuuuac gacaagaucc ugcuuuucaa acaugacccc      300

acgucggcca accuccugca gcuggugcgc ucguccggag acauccagga gggcgaccug      360

guggaggugg ugcugucggc cucggccacc uucgaggacu uccagauccg cccgcacgcc      420

cucacggugc acuccuaucg ggcgccugcc uucugugauc acugcgggga gaugcucuuc      480

ggccuagugc gccagggccu caagugcgau ggcugcgggc ugaacuacca caagcgcugu      540

gccuucagca uccccaacaa cuguaguggg gcccgcaaac ggcgccuguc auccacgucu      600

cuggccagug gccacucggu gcgccucggc accuccgagu cccugcccug cacggcugaa      660

gagcugagcc guagcaccac cgaacuccug ccucgccguc ccccgucauc cucuuccucc      720

ucuucugccu caucguauac gggccgcccc auugagcugg acaagaugcu gcucuccaag      780

gucaaggugc cgcacaccuu ccucauccac agcuauacac ggcccaccgu uugccaggcu      840

ugcaagaaac uccucaaggg ccucuuccgg cagggccugc aaugcaaaga cugcaaguuu      900

aacugucaca aacgcugcgc cacccgcguc ccuaaugacu gccuggggga ggcccuuauc      960

aauggagaug ugccgaugga ggaggccacc gauuucagcg aggcugacaa gagcgcccuc     1020

auggaugagu cagaggacuc cggugucauc ccuggcuccc acucagagaa ugcgcuccac     1080

gccagugagg aggaggaagg cgagggaggc aaggcccaga gcucccuggg guacaucccc     1140

cuaaugaggg uggugcaauc ggugcgacac acgacgcgga aauccagcac cacgcugcgg     1200

gaggguuggg ugguucauua cagcaacaag gacacgcuga gaaagcggca cuauuggcgc     1260

cuggacugca aguguaucac gcucuuccag aacaacacga ccaacagaua cuauaaggaa     1320

auuccgcugu cagaaauccu cacgguggag uccgcccaga acuucagccu ugugccgccg     1380

ggcaccaacc cacacugcuu ugagaucguc acugccaaug ccaccuacuu cgugggcgag     1440

augccuggcg ggacuccggg ugggccaagu gggcaggggg cugaggccgc ccggggcugg     1500

gagacagcca uccgccaggc ccugaugccc gucauccuuc aggacgcacc cagcgcccca     1560

ggccacgcgc cccacagaca agcuucucug agcaucucug uguccaacag ucagauccaa     1620

gagaaugugg acauugccac ugucuaccag aucuucccug acgaagugcu gggcucaggg     1680

caguuuggag uggucuaugg aggaaaacac cggaagacag gccgggacgu ggcaguuaag     1740

gucauugaca aacugcgcuu cccuaccaag caggagagcc agcuccggaa ugaaguggcc     1800

auucugcaga gccugcggca ucccgggauc gugaaccugg agugcauguu cgagacgccu     1860

gagaaagugu uuguggugau ggagaagcug cauggggaca uguuggagau gauccugucc     1920

agugagaagg gccggcugcc ugagcgccuc accaaguucc ucaucaccca gauccuggug     1980

gcuuugagac accuucacuu caagaacauu guccacugug acuugaaacc agaaaacgug     2040

uugcuggcau cagcagaccc auuuccucag gugaagcugu gugacuuugg cuuugcucgc     2100

aucaucggcg agaagucguu ccgccgcuca guggugggca cgccggccua ccuggcaccc     2160

gaggugcugc ucaaccaggg cuacaaccgc ucgcuggaca uguggucagu gggcgugauc     2220

auguacguca gccucagcgg caccuucccu uucaacgagg augaggacau caaugaccag     2280

auccagaacg ccgccuucau guacccggcc agccccugga gccacaucuc agcuggagcc     2340

auugaccuca ucaacaaccu gcugcaggug aagaugcgca aacgcuacag cguggacaaa     2400

ucucucagcc accccugguu acaggaguac cagacguggc uggaccuccg agagcuggag     2460

gggaagaugg gagagcgaua caucacgcau gagagugacg acgcgcgcug ggagcaguuu     2520

gcagcagagc auccgcugcc ugggucuggg cugcccacgg acagggaucu cgguggggcc     2580

uguccaccac aggaccacga caugcagggg cuggcggagc gcaucagugu ucucuga        2637


<210>  9286
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       PRKD2__Homo_sapiens__CCDS12689.1

<400>  9286
auggccaccg cccccagcua cccggcgggc cugcccgggu cccccggccc cgggagcccg       60

cccccccccg gcgggcucga gcugcagucc ccgccccccc ugcuccccca gaucccggcc      120

cccggcagcg gcguguccuu ccacauccag aucgggcuga cccgcgaguu cguccugcuc      180

cccgccgcca gcgagcuggc ccacgugaag cagcuggcgu gcuccaucgu ggaccagaag      240

uuccccgagu gcggcuucua cgggcucuac gacaagaucc ugcuguucaa gcacgacccg      300

acgagcgcca accuccugca gcugguccgg uccagcggcg acauccagga gggggaccuc      360

guggaggugg uccuguccgc cagcgccacc uucgaggacu uccagauccg cccccacgcg      420

cugaccgugc acuccuaccg ggcccccgcc uucugcgacc acugcggcga gaugcucuuc      480

ggccuggugc gccaggggcu gaagugcgac ggcugcgggc ucaacuacca caagcggugc      540

gccuucagca uccccaacaa cugcuccggc gcccgcaagc ggcgccugag cuccaccagc      600

cuggcguccg gccacagcgu ccggcucggg acgagcgagu cccugccgug caccgccgag      660

gagcugagcc gcuccaccac cgagcuccug ccccggcgcc cccccagcuc cagcuccagc      720

uccagcgccu ccagcuacac gggccggccg aucgagcugg acaagaugcu ccuguccaag      780

gugaaggugc cccacaccuu ccugauccac agcuacaccc gccccaccgu cugccaggcc      840

ugcaagaagc uccugaaggg gcuguuccgg cagggccucc agugcaagga cugcaaguuc      900

aacugccaca agcgcugcgc cacgcgggug cccaacgacu gccuggggga ggcgcugauc      960

aacggcgacg ugccgaugga ggaggccacc gacuucuccg aggccgacaa gagcgcccuc     1020

auggacgagu ccgaggacag cggcgucauc cccggguccc acagcgagaa cgcccugcac     1080

gcgagcgagg aggaggaggg cgaggggggc aaggcccagu ccagccuggg guacaucccc     1140

cucaugcgcg uggugcaguc cguccggcac accacccgca agagcuccac gacccugcgg     1200

gagggcuggg uggugcacua cagcaacaag gacacccugc gcaagcgcca cuacuggcgg     1260

cucgacugca agugcaucac ccuguuccag aacaacacga ccaaccgcua cuacaaggag     1320

aucccgcugu ccgagauccu caccgucgag agcgcccaga acuucucccu ggugcccccc     1380

ggcaccaacc cccacugcuu cgagaucgug acggccaacg ccaccuacuu cgucggggag     1440

augccgggcg ggacccccgg cgggcccagc ggccagggcg cggaggccgc ccgggggugg     1500

gagaccgcca uccgccaggc gcugaugccc gugauccugc aggacgcccc guccgccccc     1560

ggccacgccc cccaccggca ggccagccuc uccaucagcg ucuccaacag ccagauccag     1620

gagaacgugg acaucgcgac gguguaccag aucuuccccg acgagguccu gggguccggc     1680

caguucggcg ugguguacgg gggcaagcac cgcaagaccg ggcgggacgu cgccgugaag     1740

gugaucgaca agcugcgcuu cccgaccaag caggagagcc agcuccggaa cgaggucgcc     1800

auccugcaga gccugcgcca ccccggcauc gugaaccucg agugcauguu cgagaccccc     1860

gagaaggugu ucgucgugau ggagaagcug cacggggaca ugcuggagau gauccucucc     1920

agcgagaagg gccggcugcc cgagcgccug acgaaguucc ucaucaccca gauccuggug     1980

gcccugcggc accuccacuu caagaacauc guccacugcg accugaagcc ggagaacgug     2040

cugcucgccu ccgcggaccc cuucccccag gugaagcugu gcgacuucgg cuucgcccgc     2100

aucaucgggg agaagagcuu ccggcgcucc gucgugggca cccccgccua ccuggccccg     2160

gaggugcucc ugaaccaggg guacaaccgg agccuggaca ugugguccgu cggcgugauc     2220

auguacguga gccucuccgg gaccuucccc uucaacgagg acgaggacau caacgaccag     2280

auccagaacg ccgcguucau guaccccgcc agccccuggu cccacaucag cgccggcgcc     2340

aucgaccuga ucaacaaccu gcuccagguc aagaugcgca agcgguacuc cguggacaag     2400

agccuguccc acccguggcu gcaggaguac cagacguggc ucgaccugcg cgagcuggag     2460

ggcaagaugg gggagcgcua caucacccac gagagcgacg acgcgcggug ggagcaguuc     2520

gccgccgagc acccccuccc cggcuccggg cugccgaccg accgcgaccu gggcggggcc     2580

ugcccccccc aggaccacga caugcagggc cucgccgagc ggaucagcgu gcuguga        2637


<210>  9287
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       PRKD2__Homo_sapiens__CCDS12689.1

<400>  9287
auggccaccg cccccuccua ccccgccggc cuccccggcu cccccggccc cggcuccccc       60

cccccccccg gcggccucga gcuccagucc cccccccccc uccuccccca gauccccgcc      120

cccggcuccg gcgucuccuu ccacauccag aucggccuca cccgcgaguu cguccuccuc      180

cccgccgccu ccgagcucgc ccacgucaag cagcucgccu gcuccaucgu cgaccagaag      240

uuccccgagu gcggcuucua cggccucuac gacaagaucc uccucuucaa gcacgacccc      300

accuccgcca accuccucca gcucguccgc uccuccggcg acauccagga gggcgaccuc      360

gucgaggucg uccucuccgc cuccgccacc uucgaggacu uccagauccg cccccacgcc      420

cucaccgucc acuccuaccg cgcccccgcc uucugcgacc acugcggcga gaugcucuuc      480

ggccucgucc gccagggccu caagugcgac ggcugcggcc ucaacuacca caagcgcugc      540

gccuucucca uccccaacaa cugcuccggc gcccgcaagc gccgccucuc cuccaccucc      600

cucgccuccg gccacuccgu ccgccucggc accuccgagu cccuccccug caccgccgag      660

gagcucuccc gcuccaccac cgagcuccuc ccccgccgcc cccccuccuc cuccuccucc      720

uccuccgccu ccuccuacac cggccgcccc aucgagcucg acaagaugcu ccucuccaag      780

gucaaggucc cccacaccuu ccucauccac uccuacaccc gccccaccgu cugccaggcc      840

ugcaagaagc uccucaaggg ccucuuccgc cagggccucc agugcaagga cugcaaguuc      900

aacugccaca agcgcugcgc cacccgcguc cccaacgacu gccucggcga ggcccucauc      960

aacggcgacg uccccaugga ggaggccacc gacuucuccg aggccgacaa guccgcccuc     1020

auggacgagu ccgaggacuc cggcgucauc cccggcuccc acuccgagaa cgcccuccac     1080

gccuccgagg aggaggaggg cgagggcggc aaggcccagu ccucccucgg cuacaucccc     1140

cucaugcgcg ucguccaguc cguccgccac accacccgca aguccuccac cacccuccgc     1200

gagggcuggg ucguccacua cuccaacaag gacacccucc gcaagcgcca cuacuggcgc     1260

cucgacugca agugcaucac ccucuuccag aacaacacca ccaaccgcua cuacaaggag     1320

aucccccucu ccgagauccu caccgucgag uccgcccaga acuucucccu cguccccccc     1380

ggcaccaacc cccacugcuu cgagaucguc accgccaacg ccaccuacuu cgucggcgag     1440

augcccggcg gcacccccgg cggccccucc ggccagggcg ccgaggccgc ccgcggcugg     1500

gagaccgcca uccgccaggc ccucaugccc gucauccucc aggacgcccc cuccgccccc     1560

ggccacgccc cccaccgcca ggccucccuc uccaucuccg ucuccaacuc ccagauccag     1620

gagaacgucg acaucgccac cgucuaccag aucuuccccg acgagguccu cggcuccggc     1680

caguucggcg ucgucuacgg cggcaagcac cgcaagaccg gccgcgacgu cgccgucaag     1740

gucaucgaca agcuccgcuu ccccaccaag caggaguccc agcuccgcaa cgaggucgcc     1800

auccuccagu cccuccgcca ccccggcauc gucaaccucg agugcauguu cgagaccccc     1860

gagaaggucu ucgucgucau ggagaagcuc cacggcgaca ugcucgagau gauccucucc     1920

uccgagaagg gccgccuccc cgagcgccuc accaaguucc ucaucaccca gauccucguc     1980

gcccuccgcc accuccacuu caagaacauc guccacugcg accucaagcc cgagaacguc     2040

cuccucgccu ccgccgaccc cuucccccag gucaagcucu gcgacuucgg cuucgcccgc     2100

aucaucggcg agaaguccuu ccgccgcucc gucgucggca cccccgccua ccucgccccc     2160

gagguccucc ucaaccaggg cuacaaccgc ucccucgaca ugugguccgu cggcgucauc     2220

auguacgucu cccucuccgg caccuucccc uucaacgagg acgaggacau caacgaccag     2280

auccagaacg ccgccuucau guaccccgcc ucccccuggu cccacaucuc cgccggcgcc     2340

aucgaccuca ucaacaaccu ccuccagguc aagaugcgca agcgcuacuc cgucgacaag     2400

ucccucuccc accccuggcu ccaggaguac cagaccuggc ucgaccuccg cgagcucgag     2460

ggcaagaugg gcgagcgcua caucacccac gaguccgacg acgcccgcug ggagcaguuc     2520

gccgccgagc acccccuccc cggcuccggc cuccccaccg accgcgaccu cggcggcgcc     2580

ugcccccccc aggaccacga caugcagggc cucgccgagc gcaucuccgu ccucuga        2637


<210>  9288
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       PRKD2__Homo_sapiens__CCDS12689.1

<400>  9288
auggccaccg cucccagcua cccugcaggc cugccagggu ccccgggacc cgguucuccu       60

ccacccccug gcgggcucga gcuucaguca ccacccccuc uguugccaca aaucccggcc      120

cccggaagug gcgugagcuu ccacauucag auagguuuaa caagagaauu uguccugcua      180

ccugcggcuu ccgagcucgc ccauguuaag cagcuggcau gcucuaucgu ggaccagaaa      240

uucccagaau guggguuuua uggacuuuac gauaagauuc uguuguucaa acacgacccc      300

acuucggcca accuccugca acugguaagg ucaagcggcg auauccagga gggcgaccuc      360

guggaagucg uguuaagugc uuccgcaacg uuugaggauu uccagauucg gccucaugcc      420

cugaccguuc acucuuaucg cgcuccagcc uuuugcgacc auugugggga gaugcuuuuc      480

ggauuggugc gacagggucu gaagugcgau ggcugugggc uaaauuacca caaacguugc      540

gcguuuagca uccccaacaa uuguuccgga gcaagaaaga ggcggcucuc aaguacaagc      600

cuggccucug gccacuccgu ccgccuuggu acuucagaaa gccugccgug caccgcugag      660

gaauugagua gaucuacaac cgagcuccug ccuaggcggc ccccauccag cucgucuucc      720

ucaagugcca gcuccuauac ugggcgcccu auagaguuag acaagaugcu gcucucuaaa      780

gugaagguac cccauacauu ccuuauccac agcuacaccc gaccaacggu uugucaagca      840

ugcaaaaagc uguugaaagg acuauuuaga cagggccugc aguguaagga uugcaaguuc      900

aacugccaua aaaggugugc uacucgggug cccaaugacu gccucggcga agcccugauu      960

aacggggaug ucccuaugga ggaagcgacc gacuuuucag aggccgauaa gagugcacuu     1020

auggacgaau ccgaggacag cggagugauc ccagguucuc acucagagaa ugcucugcac     1080

gccagugaag aggaagaggg cgaaggggga aaagcucaga gcuccuuggg cuauauuccg     1140

cucaugcgug ugguccaauc uguucgccau acaacuagaa agucgagcac cacacugagg     1200

gaggguuggg ugguacacua cuccaacaaa gauaccuuac ggaagcgaca uuacuggcgc     1260

cuggacugua aaugcaucac gcuauuccag aauaacacua caaauagaua uuacaaggag     1320

auaccccucu cagaaauucu gaccguggag agugcccaga acuucucucu ugucccucca     1380

gggacuaauc cccacuguuu ugaaaucgug acagcaaacg ccaccuauuu cguuggcgag     1440

augccuggag gcacgccagg gggacccagc ggucaaggcg cugaagcggc aagggggugg     1500

gagaccgcca uucggcaggc uuugaugccg gugauccugc aggaugcccc uuccgcacca     1560

ggacaugcuc cccaccgcca ggccucacuc agcaucucug ucuccaauag ucaaauucag     1620

gagaacgugg acauagccac aguauaccag aucuuuccug augaaguucu gggcagcggu     1680

caguucgggg uggucuaugg cggaaagcac agaaaaacug gcagggacgu ggcagucaag     1740

gugauugaua aacuucguuu ucccaccaag caagagucuc agcugcggaa cgaaguugcg     1800

aucuugcagu cccuccgaca uccagggaua gugaaucugg agugcauguu cgagacaccu     1860

gaaaaaguau uugucgugau ggagaaguua cacggagaca ugcuggaaau gauucuauca     1920

agugagaagg guagacuccc cgaaaggcug acuaaauucc uuaucaccca gaucuugguu     1980

gcucugcgcc aucuccacuu uaagaacauu gugcacugug aucugaaacc agagaauguc     2040

uuacuggcca gcgcagaccc guucccucaa gugaaacuuu gcgauuuugg cuucgcccgg     2100

aucauugggg agaagucguu uagaaggucc guagugggaa cacccgcuua cuuggcccca     2160

gaaguucucc ugaaccaggg cuauaaucgc ucucuagaca uguggagcgu cggugugaua     2220

auguacgugu cacugagugg gaccuucccc uucaacgagg acgaagauau caaugaccag     2280

auucagaacg cagcuuuuau guacccugcc uccccauggu cucauaucag cgcgggcgcc     2340

aucgaucuca uuaauaaccu gcuucaaguc aagaugcgaa agcgguauuc cguugacaaa     2400

ucauugagcc accccuggcu gcaggaguac cagacuuggu uagaucuccg ugaacuggag     2460

ggaaagaugg gcgagagaua uauaacgcau gaaagugacg augcuaggug ggagcaauuc     2520

gcagccgaac acccucuucc ggggucugga cugccaacag accgcgauuu gggcggugcu     2580

ugucccccuc aggaccauga uaugcagggg cucgccgagc ggaucuccgu gcuguga        2637


<210>  9289
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       PRKD2__Homo_sapiens__CCDS12689.1

<400>  9289
auggccaccg cccccagcua ccccgccggc cugcccggca gccccggccc cggcagcccc       60

cccccccccg gcggccugga gcugcagagc cccccccccc ugcugcccca gauccccgcc      120

cccggcagcg gcgugagcuu ccacauccag aucggccuga ccagagaguu cgugcugcug      180

cccgccgcca gcgagcuggc ccacgugaag cagcuggccu gcagcaucgu ggaccagaag      240

uuccccgagu gcggcuucua cggccuguac gacaagaucc ugcuguucaa gcacgacccc      300

accagcgcca accugcugca gcuggugaga agcagcggcg acauccagga gggcgaccug      360

guggaggugg ugcugagcgc cagcgccacc uucgaggacu uccagaucag accccacgcc      420

cugaccgugc acagcuacag agcccccgcc uucugcgacc acugcggcga gaugcuguuc      480

ggccugguga gacagggccu gaagugcgac ggcugcggcc ugaacuacca caagagaugc      540

gccuucagca uccccaacaa cugcagcggc gccagaaaga gaagacugag cagcaccagc      600

cuggccagcg gccacagcgu gagacugggc accagcgaga gccugcccug caccgccgag      660

gagcugagca gaagcaccac cgagcugcug cccagaagac cccccagcag cagcagcagc      720

agcagcgcca gcagcuacac cggcagaccc aucgagcugg acaagaugcu gcugagcaag      780

gugaaggugc cccacaccuu ccugauccac agcuacacca gacccaccgu gugccaggcc      840

ugcaagaagc ugcugaaggg ccuguucaga cagggccugc agugcaagga cugcaaguuc      900

aacugccaca agagaugcgc caccagagug cccaacgacu gccugggcga ggcccugauc      960

aacggcgacg ugcccaugga ggaggccacc gacuucagcg aggccgacaa gagcgcccug     1020

auggacgaga gcgaggacag cggcgugauc cccggcagcc acagcgagaa cgcccugcac     1080

gccagcgagg aggaggaggg cgagggcggc aaggcccaga gcagccuggg cuacaucccc     1140

cugaugagag uggugcagag cgugagacac accaccagaa agagcagcac cacccugaga     1200

gagggcuggg uggugcacua cagcaacaag gacacccuga gaaagagaca cuacuggaga     1260

cuggacugca agugcaucac ccuguuccag aacaacacca ccaacagaua cuacaaggag     1320

aucccccuga gcgagauccu gaccguggag agcgcccaga acuucagccu ggugcccccc     1380

ggcaccaacc cccacugcuu cgagaucgug accgccaacg ccaccuacuu cgugggcgag     1440

augcccggcg gcacccccgg cggccccagc ggccagggcg ccgaggccgc cagaggcugg     1500

gagaccgcca ucagacaggc ccugaugccc gugauccugc aggacgcccc cagcgccccc     1560

ggccacgccc cccacagaca ggccagccug agcaucagcg ugagcaacag ccagauccag     1620

gagaacgugg acaucgccac cguguaccag aucuuccccg acgaggugcu gggcagcggc     1680

caguucggcg ugguguacgg cggcaagcac agaaagaccg gcagagacgu ggccgugaag     1740

gugaucgaca agcugagauu ccccaccaag caggagagcc agcugagaaa cgagguggcc     1800

auccugcaga gccugagaca ccccggcauc gugaaccugg agugcauguu cgagaccccc     1860

gagaaggugu ucguggugau ggagaagcug cacggcgaca ugcuggagau gauccugagc     1920

agcgagaagg gcagacugcc cgagagacug accaaguucc ugaucaccca gauccuggug     1980

gcccugagac accugcacuu caagaacauc gugcacugcg accugaagcc cgagaacgug     2040

cugcuggcca gcgccgaccc cuucccccag gugaagcugu gcgacuucgg cuucgccaga     2100

aucaucggcg agaagagcuu cagaagaagc guggugggca cccccgccua ccuggccccc     2160

gaggugcugc ugaaccaggg cuacaacaga agccuggaca uguggagcgu gggcgugauc     2220

auguacguga gccugagcgg caccuucccc uucaacgagg acgaggacau caacgaccag     2280

auccagaacg ccgccuucau guaccccgcc agccccugga gccacaucag cgccggcgcc     2340

aucgaccuga ucaacaaccu gcugcaggug aagaugagaa agagauacag cguggacaag     2400

agccugagcc accccuggcu gcaggaguac cagaccuggc uggaccugag agagcuggag     2460

ggcaagaugg gcgagagaua caucacccac gagagcgacg acgccagaug ggagcaguuc     2520

gccgccgagc acccccugcc cggcagcggc cugcccaccg acagagaccu gggcggcgcc     2580

ugcccccccc aggaccacga caugcagggc cuggccgaga gaaucagcgu gcuguga        2637


<210>  9290
<211>  2637
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       PRKD2__Homo_sapiens__CCDS12689.1

<400>  9290
auggccaccg cucccagcua cccugccggc cugccggggu cccccggacc uggcucuccc       60

ccucccccug ggggacucga gcugcagagc ccgcccccuc uucugcccca aaucccugcg      120

cccggcuccg gggugucuuu ccacauucag aucggacuca caagagaauu uguccugcuu      180

ccggcugcca gcgagcuggc ccauguuaag cagcucgcuu gcuccauugu ggaccagaaa      240

uucccugaau guggcuuuua uggccuguac gauaagaucc uccuguucaa acacgacccc      300

acgucugcca accugcuuca acuggugcgg agcuccgggg auauucagga gggagaccuc      360

gucgaagugg uucugagcgc uucugccacc uuugaggauu uccagauccg cccucaugcg      420

cuuacagugc acuccuauag agcccccgcu uuuugcgacc auuguggcga gaugcuguuc      480

gggcucgucc ggcagggacu gaagugcgau ggcugugggc ugaauuacca caaacgcugc      540

gccuuuagca uccccaacaa uuguucugga gcuagaaagc ggcgccucuc cagcaccucu      600

cuggccuccg gccacagcgu gagacuuggc acauccgaau cucugccuug caccgcggag      660

gaacucagcc gguccacaac cgagcugcuu ccgcgcagac ccccuagcag cuccagcucu      720

agcuccgccu cuagcuauac ggggcggccc auugagcugg acaagaugcu ccuguccaaa      780

guuaaggugc cucauaccuu ccugauccac agcuacacac gccccaccgu cugucaggcu      840

ugcaaaaagc uccugaaagg acuuuuuaga caaggccugc aguguaagga uugcaaguuc      900

aacugccaua aacggugugc cacacgcgug ccgaaugacu gccucgggga agcucugauu      960

aacggagaug ugccuaugga ggaagccacc gacuuuucug aggccgauaa guccgcucuu     1020

auggacgaaa gcgaggacuc uggcgucauc cccggguccc acagcgagaa ugcgcugcac     1080

gccuccgaag aggaagaggg agaaggcggc aaagcucagu cuagccucgg guauauuccu     1140

cugaugagag uugugcaauc cgugcggcau acgacaagaa agucuagcac cacacugcgc     1200

gagggauggg ucgugcacua cuccaacaaa gauacccucc ggaagagaca uuacuggcgc     1260

cuggacugua aaugcaucac ccuuuuccag aauaacacaa cgaaucggua uuacaaggag     1320

auuccccuga gcgaaauccu caccguugag ucugcccaga acuucucccu ggugccuccc     1380

ggcacaaauc cgcacuguuu ugaaaucguc accgccaacg cuacauauuu cgugggggag     1440

augccuggag gcacccccgg gggccccagc ggacaaggcg ccgaagcggc uagagggugg     1500

gagacggcca uucgccaggc ccugaugccu guuauccuuc aggaugcucc gucugccccc     1560

ggacaugcuc cucaccggca ggccucccuc agcauuucug ugagcaauuc ccaaauccag     1620

gagaacgucg acauugcgac aguguaccag aucuuucccg augaaguccu gggcagcggg     1680

caguucggag ugguuuaugg cgggaagcac agaaaaaccg gccgcgacgu ggccgucaag     1740

gugaucgaua aacugcgguu uccuaccaag caagagucuc agcucagaaa cgaaguugcu     1800

auucugcagu cccuucgcca ucccggaauc gugaaucugg agugcauguu cgagacaccu     1860

gaaaaagucu uuguggugau ggagaagcuc cacggcgaca ugcuggaaau gauucugagc     1920

uccgagaagg ggcggcuucc cgaaagacuc accaaauucc ugaucacaca gauucugguu     1980

gcccuccggc aucugcacuu uaagaacauc guccacugug aucuuaaacc ggagaaugug     2040

cugcucgcuu cugccgaccc uuucccccaa gugaagcugu gcgauuuugg auucgcgcgc     2100

aucauuggcg agaaaucuuu uagacggucc gucgugggga cgccugccua ccuggcuccc     2160

gaaguucuuc ucaaccaggg auauaauaga ucucuggaca uguggagcgu gggcgucauc     2220

auguacgugu cccugucugg gaccuucccg uucaacgagg acgaagauau uaaugaccag     2280

auccagaacg ccgcuuuuau guacccugcc agccccuggu cccauauuag cgccggcgcu     2340

aucgaucuca uuaauaaccu gcuucaaguu aagaugcgca agcgguauuc uguggacaaa     2400

ucccugagcc acccuuggcu ccaggaguac cagacauggc uggaucugag agaacuugag     2460

ggaaagaugg gcgagcgcua uaucacccau gaaucugacg augcgagaug ggagcaauuc     2520

gccgcugaac acccccuccc cggguccgga cugccuacag accgggaucu gggcggggcc     2580

uguccgcccc aggaccauga uaugcaggga cucgccgagc gcaucagcgu ccuguga        2637


<210>  9291
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rab__Homo_sapiens__P52594

<400>  9291

Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Gly 
            260                 265                 270         


Gly Ser Ala Ala Ser Val Asn Ala Asn Phe Ala His Phe Asp Asn Phe 
        275                 280                 285             


Pro Lys Ser Ser Ser Ala Asp Phe Gly Thr Phe Asn Thr Ser Gln Ser 
    290                 295                 300                 


His Gln Thr Ala Ser Ala Val Ser Lys Val Ser Thr Asn Lys Ala Gly 
305                 310                 315                 320 


Leu Gln Thr Ala Asp Lys Tyr Ala Ala Leu Ala Asn Leu Asp Asn Ile 
                325                 330                 335     


Phe Ser Ala Gly Gln Gly Gly Asp Gln Gly Ser Gly Phe Gly Thr Thr 
            340                 345                 350         


Gly Lys Ala Pro Val Gly Ser Val Val Ser Val Pro Ser Gln Ser Ser 
        355                 360                 365             


Ala Ser Ser Asp Lys Tyr Ala Ala Leu Ala Glu Leu Asp Ser Val Phe 
    370                 375                 380                 


Ser Ser Ala Ala Thr Ser Ser Asn Ala Tyr Thr Ser Thr Ser Asn Ala 
385                 390                 395                 400 


Ser Ser Asn Val Phe Gly Thr Val Pro Val Val Ala Ser Ala Gln Thr 
                405                 410                 415     


Gln Pro Ala Ser Ser Ser Val Pro Ala Pro Phe Gly Ala Thr Pro Ser 
            420                 425                 430         


Thr Asn Pro Phe Val Ala Ala Ala Gly Pro Ser Val Ala Ser Ser Thr 
        435                 440                 445             


Asn Pro Phe Gln Thr Asn Ala Arg Gly Ala Thr Ala Ala Thr Phe Gly 
    450                 455                 460                 


Thr Ala Ser Met Ser Met Pro Thr Gly Phe Gly Thr Pro Ala Pro Tyr 
465                 470                 475                 480 


Ser Leu Pro Thr Ser Phe Ser Gly Ser Phe Gln Gln Pro Ala Phe Pro 
                485                 490                 495     


Ala Gln Ala Ala Phe Pro Gln Gln Thr Ala Phe Ser Gln Gln Pro Asn 
            500                 505                 510         


Gly Ala Gly Phe Ala Ala Phe Gly Gln Thr Lys Pro Val Val Thr Pro 
        515                 520                 525             


Phe Gly Gln Val Ala Ala Ala Gly Val Ser Ser Asn Pro Phe Met Thr 
    530                 535                 540                 


Gly Ala Pro Thr Gly Gln Phe Pro Thr Gly Ser Ser Ser Thr Asn Pro 
545                 550                 555                 560 


Phe Leu 
        


<210>  9292
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rab__Homo_sapiens__AAC37580

<400>  9292
auggcggcca gcgcgaagcg gaagcaggag gagaagcacc ugaagaugcu gcgggacaug       60

accggccucc cgcacaaccg aaagugcuuc gacugcgacc agcgcggccc caccuacguu      120

aacaugacgg ucggcuccuu cguguguacc uccugcuccg gcagccugcg aggauuaaau      180

ccaccacaca gggugaaauc uaucuccaug acaacauuca cacaacagga aauugaauuc      240

uuacaaaaac auggaaauga agucuguaaa cagauuuggc uaggauuauu ugaugauaga      300

ucuucagcaa uuccagacuu cagggaucca caaaaaguga aagaguuucu acaagaaaag      360

uaugaaaaga aaagauggua ugucccgcca gaacaagcca aagucguggc aucaguucau      420

gcaucuauuu caggguccuc ugccaguagc acaagcagca caccugaggu caaaccacug      480

aaaucucuuu uaggggauuc ugcaccaaca cugcacuuaa auaagggcac accuagucag      540

uccccaguug uaggucguuc ucaagggcag cagcaggaga agaagcaauu ugaccuuuua      600

agugaucucg gcucagacau cuuugcugcu ccagcuccuc agucaacagc uacagccaau      660

uuugcuaacu uugcacauuu caacagucau gcagcucaga auucugcaaa ugcagauuuu      720

gcaaacuuug augcauuugg acagucuagu gguucgagua auuuuggagg uuuccccaca      780

gcaagucacu cuccuuuuca gccccaaacu acagguggaa gugcugcauc aguaaaugcu      840

aauuuugcuc auuuugauaa cuuccccaaa uccuccagug cugauuuugg aaccuucaau      900

acuucccaga gucaucaaac agcaucagcu guuaguaaag uuucaacgaa caaagcuggu      960

uuacagacug cagacaaaua ugcagcacuu gcuaauuuag acaauaucuu cagugccggg     1020

caagguggug aucagggaag uggcuuuggg accacaggua aagcuccugu ugguucugug     1080

guuucaguuc ccagucaguc aagugcaucu ucagacaagu augcagcucu ggcagaacua     1140

gacagcguuu ucaguucugc agccaccucc aguaaugcgu auacuuccac aaguaaugcu     1200

agcagcaaug uuuuuggaac agugccagug guugcuucug cacagacaca gccugcuuca     1260

ucaagugugc cugcuccauu uggagcuacg ccuuccacaa auccauuugu ugcugcugcu     1320

gguccuucug uggcaucuuc uacaaaccca uuucagacca augccagagg agcaacagcg     1380

gcaaccuuug gcacugcauc caugagcaug cccacgggau ucggcacucc ugcucccuac     1440

agucuuccca ccagcuuuag uggcagcuuu cagcagccug ccuuuccagc ccaagcagcu     1500

uucccucaac agacagcuuu uucucaacag cccaauggug cagguuuugc agcauuugga     1560

caaacaaagc caguaguaac cccuuuuggu caaguugcag cugcuggagu aucuaguaau     1620

ccuuuuauga cuggugcacc aacaggacaa uuuccaacag gaagcucauc aaccaauccu     1680

uucuuauag                                                             1689


<210>  9293
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rab__Homo_sapiens__AAC37580

<400>  9293
auggccgcca gcgcgaagcg caagcaggag gagaagcacc ugaagaugcu ccgggacaug       60

accggccugc cccacaaccg caagugcuuc gacugcgacc agcgggggcc gaccuacgug      120

aacaugacgg ucggcuccuu cgugugcacc agcugcuccg ggagccugcg cggccucaac      180

ccgccccacc gggugaaguc caucagcaug accaccuuca cgcagcagga gaucgaguuc      240

cugcagaagc acgggaacga ggucugcaag cagaucuggc ugggccucuu cgacgaccgc      300

uccagcgcca uccccgacuu ccgggacccc cagaagguga aggaguuccu gcaggagaag      360

uacgagaaga agcgcuggua cgugccgccc gagcaggcca aggucguggc cuccgugcac      420

gccagcaucu ccggcagcuc cgcgagcucc accagcucca cccccgaggu caagccccuc      480

aagagccugc ugggggacuc cgcccccacc cugcaccuca acaagggcac gcccagccag      540

agccccgugg uggggcgguc ccagggccag cagcaggaga agaagcaguu cgaccugcug      600

agcgaccucg gguccgacau cuucgccgcc ccggcgcccc agagcaccgc caccgccaac      660

uucgccaacu ucgcccacuu caacucccac gcggcccaga acagcgccaa cgccgacuuc      720

gccaacuucg acgcguucgg ccaguccagc ggcuccagca acuucggggg cuuccccacc      780

gccucccaca gccccuucca gccgcagacg accgggggcu ccgccgccag cgucaacgcc      840

aacuucgcgc acuucgacaa cuuccccaag uccagcuccg ccgacuucgg caccuucaac      900

accagccagu cccaccagac ggccagcgcc gugagcaagg uguccaccaa caaggccggg      960

cugcagaccg cggacaagua cgccgcccug gccaaccucg acaacaucuu cagcgcgggc     1020

cagggcgggg accagggguc cggcuucggc accacgggga aggcccccgu cggcagcgug     1080

guguccgucc ccagccaguc cagcgccucc agcgacaagu acgccgcccu ggcggagcug     1140

gacuccgugu ucagcuccgc cgccaccagc uccaacgccu acaccagcac cuccaacgcc     1200

agcagcaacg uguucgggac ggucccggug guggcguccg cccagaccca gcccgccagc     1260

uccagcgucc ccgcccccuu cggcgccacc ccguccacca accccuucgu ggcggccgcc     1320

gggcccagcg ucgccuccag cacgaacccc uuccagacca acgcgcgcgg cgccaccgcc     1380

gccaccuucg gcacggccuc caugagcaug ccgaccgggu ucggcacccc cgcgcccuac     1440

ucccucccga ccagcuucuc cgggagcuuc cagcagcccg ccuuccccgc ccaggccgcc     1500

uucccccagc agacggcguu cucccagcag ccgaacggcg ccggguucgc cgccuucggc     1560

cagaccaagc ccguggugac ccccuucggc caggucgccg cggccggggu gagcuccaac     1620

cccuucauga ccggcgcccc gaccgggcag uuccccacgg gcagcuccag caccaacccc     1680

uuccuguga                                                             1689


<210>  9294
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rab__Homo_sapiens__AAC37580

<400>  9294
auggccgccu ccgccaagcg caagcaggag gagaagcacc ucaagaugcu ccgcgacaug       60

accggccucc cccacaaccg caagugcuuc gacugcgacc agcgcggccc caccuacguc      120

aacaugaccg ucggcuccuu cgucugcacc uccugcuccg gcucccuccg cggccucaac      180

cccccccacc gcgucaaguc caucuccaug accaccuuca cccagcagga gaucgaguuc      240

cuccagaagc acggcaacga ggucugcaag cagaucuggc ucggccucuu cgacgaccgc      300

uccuccgcca uccccgacuu ccgcgacccc cagaagguca aggaguuccu ccaggagaag      360

uacgagaaga agcgcuggua cguccccccc gagcaggcca aggucgucgc cuccguccac      420

gccuccaucu ccggcuccuc cgccuccucc accuccucca cccccgaggu caagccccuc      480

aagucccucc ucggcgacuc cgcccccacc cuccaccuca acaagggcac ccccucccag      540

ucccccgucg ucggccgcuc ccagggccag cagcaggaga agaagcaguu cgaccuccuc      600

uccgaccucg gcuccgacau cuucgccgcc cccgcccccc aguccaccgc caccgccaac      660

uucgccaacu ucgcccacuu caacucccac gccgcccaga acuccgccaa cgccgacuuc      720

gccaacuucg acgccuucgg ccaguccucc ggcuccucca acuucggcgg cuuccccacc      780

gccucccacu cccccuucca gccccagacc accggcggcu ccgccgccuc cgucaacgcc      840

aacuucgccc acuucgacaa cuuccccaag uccuccuccg ccgacuucgg caccuucaac      900

accucccagu cccaccagac cgccuccgcc gucuccaagg ucuccaccaa caaggccggc      960

cuccagaccg ccgacaagua cgccgcccuc gccaaccucg acaacaucuu cuccgccggc     1020

cagggcggcg accagggcuc cggcuucggc accaccggca aggcccccgu cggcuccguc     1080

gucuccgucc ccucccaguc cuccgccucc uccgacaagu acgccgcccu cgccgagcuc     1140

gacuccgucu ucuccuccgc cgccaccucc uccaacgccu acaccuccac cuccaacgcc     1200

uccuccaacg ucuucggcac cguccccguc gucgccuccg cccagaccca gcccgccucc     1260

uccuccgucc ccgcccccuu cggcgccacc cccuccacca accccuucgu cgccgccgcc     1320

ggccccuccg ucgccuccuc caccaacccc uuccagacca acgcccgcgg cgccaccgcc     1380

gccaccuucg gcaccgccuc cauguccaug cccaccggcu ucggcacccc cgcccccuac     1440

ucccucccca ccuccuucuc cggcuccuuc cagcagcccg ccuuccccgc ccaggccgcc     1500

uucccccagc agaccgccuu cucccagcag cccaacggcg ccggcuucgc cgccuucggc     1560

cagaccaagc ccgucgucac ccccuucggc caggucgccg ccgccggcgu cuccuccaac     1620

cccuucauga ccggcgcccc caccggccag uuccccaccg gcuccuccuc caccaacccc     1680

uuccucuga                                                             1689


<210>  9295
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rab__Homo_sapiens__AAC37580

<400>  9295
auggccgcua gcgcaaagag aaaacaggag gaaaagcacc ugaaaaugcu cagggacaug       60

accggccuuc cccauaaccg gaagugcuuc gauugugacc aacgcgggcc uacauacgug      120

aauaugacug ucggauccuu uguuugcacg ucuuguucag guagucugcg aggcuugaac      180

ccaccgcacc gugugaaaag caucuccaug accacauuca cucagcagga gauugaauuu      240

uuacagaagc augggaauga gguaugcaag caaauauggc ugggacuauu cgaugacaga      300

ucuucggcca uccccgauuu uagggacccu cagaaaguga aggaguuccu ccaggaaaaa      360

uaugagaaga aacgguggua cgucccaccc gaacaggcga aggugguugc uucagugcac      420

gccagcauua guggcuccuc ugcaagcucc accucaagua caccugaggu caagccacug      480

aaaagccuuc ugggugauuc ugcccccacc uugcaucuca acaaggggac uccuucccaa      540

ucaccagugg uaggacgcag ccagggccag cagcaagaga aaaagcaguu ugaccugcug      600

agugaucucg gcucugacau cuucgcugca ccggcucccc aguccacagc caccgccaau      660

uuugcgaacu ucgcacacuu uaauagccac gccgcucaaa acucggccaa ugcagauuuc      720

gcuaacuuug acgccuucgg gcagucuucc ggaucaagua auuucggugg cuuuccuacg      780

gcgagccauu ccccauucca gccccagacu accgggggau cugccgcaag cguuaacgcu      840

aauuuugccc acuucgauaa cuuuccuaaa ucaaguuccg cugacuucgg cacauuuaau      900

acuagccaau cucaucagac cgccucagca gugaguaagg ucagcacaaa caaagccggu      960

uuacagaccg cugacaagua ugcggcacug gccaaccuug auaauauuuu cuccgcuggg     1020

cagggaggcg accaaggcuc uggguuugga acgacuggua aggccccagu gggcucggug     1080

gucagcguuc ccucccaguc aagugcaucu agcgauaaau acgccgcuuu ggccgaacug     1140

gacuccgugu ucucaagcgc agcgacaucu uccaacgcuu auaccaguac uagcaaugcc     1200

ucuuccaacg uauuugggac agugccgguc guggcaucag cccagaccca gccugcuagu     1260

agcucgguuc ccgccccauu cggagcaacg ccuuccacca aucccuuugu ggcugccgcg     1320

ggcccaucug ucgccagcuc aacaaacccc uuccaaacua augcuagagg ugcaaccgcc     1380

gcuacauucg ggacugccag uauguccaug ccuaccggcu uuggaacacc agcaccguac     1440

ucucuaccca ccagcuucuc cggcucauuu cagcagccug cguucccagc ccaggcugcc     1500

uuuccccaac agacugcauu cagccagcaa ccuaacgggg cuggauuugc cgcauucggu     1560

cagacgaagc cagugguaac acccuuuggc cagguugccg cugcgggggu gaguucuaau     1620

ccguucauga ccggagcccc uacuggccag uuuccaaccg guuccagcuc gacaaacccc     1680

uuccucuga                                                             1689


<210>  9296
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rab__Homo_sapiens__AAC37580

<400>  9296
auggccgcca gcgccaagag aaagcaggag gagaagcacc ugaagaugcu gagagacaug       60

accggccugc cccacaacag aaagugcuuc gacugcgacc agagaggccc caccuacgug      120

aacaugaccg ugggcagcuu cgugugcacc agcugcagcg gcagccugag aggccugaac      180

cccccccaca gagugaagag caucagcaug accaccuuca cccagcagga gaucgaguuc      240

cugcagaagc acggcaacga ggugugcaag cagaucuggc ugggccuguu cgacgacaga      300

agcagcgcca uccccgacuu cagagacccc cagaagguga aggaguuccu gcaggagaag      360

uacgagaaga agagauggua cgugcccccc gagcaggcca aggugguggc cagcgugcac      420

gccagcauca gcggcagcag cgccagcagc accagcagca cccccgaggu gaagccccug      480

aagagccugc ugggcgacag cgcccccacc cugcaccuga acaagggcac ccccagccag      540

agccccgugg ugggcagaag ccagggccag cagcaggaga agaagcaguu cgaccugcug      600

agcgaccugg gcagcgacau cuucgccgcc cccgcccccc agagcaccgc caccgccaac      660

uucgccaacu ucgcccacuu caacagccac gccgcccaga acagcgccaa cgccgacuuc      720

gccaacuucg acgccuucgg ccagagcagc ggcagcagca acuucggcgg cuuccccacc      780

gccagccaca gccccuucca gccccagacc accggcggca gcgccgccag cgugaacgcc      840

aacuucgccc acuucgacaa cuuccccaag agcagcagcg ccgacuucgg caccuucaac      900

accagccaga gccaccagac cgccagcgcc gugagcaagg ugagcaccaa caaggccggc      960

cugcagaccg ccgacaagua cgccgcccug gccaaccugg acaacaucuu cagcgccggc     1020

cagggcggcg accagggcag cggcuucggc accaccggca aggcccccgu gggcagcgug     1080

gugagcgugc ccagccagag cagcgccagc agcgacaagu acgccgcccu ggccgagcug     1140

gacagcgugu ucagcagcgc cgccaccagc agcaacgccu acaccagcac cagcaacgcc     1200

agcagcaacg uguucggcac cgugcccgug guggccagcg cccagaccca gcccgccagc     1260

agcagcgugc ccgcccccuu cggcgccacc cccagcacca accccuucgu ggccgccgcc     1320

ggccccagcg uggccagcag caccaacccc uuccagacca acgccagagg cgccaccgcc     1380

gccaccuucg gcaccgccag caugagcaug cccaccggcu ucggcacccc cgcccccuac     1440

agccugccca ccagcuucag cggcagcuuc cagcagcccg ccuuccccgc ccaggccgcc     1500

uucccccagc agaccgccuu cagccagcag cccaacggcg ccggcuucgc cgccuucggc     1560

cagaccaagc ccguggugac ccccuucggc cagguggccg ccgccggcgu gagcagcaac     1620

cccuucauga ccggcgcccc caccggccag uuccccaccg gcagcagcag caccaacccc     1680

uuccuguga                                                             1689


<210>  9297
<211>  1689
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rab__Homo_sapiens__AAC37580

<400>  9297
auggccgcua gcgccaagag aaaacaggag gaaaagcacc ugaaaaugcu ccgggacaug       60

accggccugc cccauaaccg caagugcuuc gauugugacc aaagagggcc uacauacgug      120

aauaugacgg ucggauccuu uguuugcacc ucuuguagcg gcucccuucg ggggcugaac      180

ccgccccacc gcgugaaauc uaucagcaug acaaccuuca cacagcagga gauugaauuu      240

cuccagaagc auggaaauga ggugugcaag caaaucuggc ugggccuuuu cgaugacaga      300

uccucugcga uuccugauuu ucgggacccc cagaaaguca aggaguuccu gcaggaaaaa      360

uaugagaaga aacgcuggua cgugccuccc gaacaggcua agguuguggc cagcguccac      420

gccuccauca gcgggucuuc cgcuagcucu accuccagca caccugaggu gaagccgcuc      480

aaaucucugc ugggagauuc cgcccccacc cuccaucuga acaagggcac gccuagccaa      540

ucccccguug ugggcagauc ucaggggcag cagcaagaga aaaagcaguu ugaccuucug      600

agcgaucucg gauccgacau uuucgcugcc ccugcgcccc agagcaccgc cacagcuaau      660

uuugccaacu ucgcucacuu uaauucucac gccgcgcaaa acuccgccaa ugcugauuuc      720

gccaacuuug acgcuuucgg ccagagcucu gggagcucca auuucggagg cuuuccgacc      780

gccucucaua gcccuuucca gccccagaca accgggggau ccgccgcuag cgucaacgcg      840

aauuuugccc acuucgauaa cuuuccuaaa ucuuccagcg cugacuucgg cacguuuaau      900

acaucucaau cccaucagac cgccagcgcc guguccaagg ugucuacaaa caaagcuggc      960

cugcagaccg ccgacaagua ugcggcucuu gccaaccugg auaauaucuu cagcgccggg     1020

cagggaggcg accaaggguc cggauuuggc accacaggga aggcucccgu cggaucuguu     1080

gugagcgugc ccucccagag cucugccucc agcgauaaau acgcugcccu cgcggaacug     1140

gacucugucu ucuccagcgc cgcuacgucu agcaacgccu auaccuccac aagcaaugcu     1200

ucuuccaacg uguuuggcac cguuccugug gucgccagcg cgcagacaca gccggccucc     1260

ucuagcgugc ccgcuccuuu cggcgccacc cccuccacga auccuuuugu ugcugccgcc     1320

gggcccucug uggcuagcuc cacaaacccg uuccaaacca augcgcgggg agccaccgcu     1380

gccacauucg gcaccgccuc uaugagcaug ccuacagggu uuggaacgcc cgcuccuuac     1440

ucccugccca ccagcuucuc uggcuccuuu cagcagccug ccuuccccgc gcaggcugcc     1500

uuuccgcaac agacagccuu cagccagcaa ccuaacgggg cuggcuuugc cgcguucgga     1560

cagaccaagc ccgucgugac acccuuuggc caggucgcug ccgccggggu gucuuccaau     1620

ccuuucauga ccggagcucc gacgggccag uuucccaccg ggucuagcuc cacaaacccu     1680

uuccucuga                                                             1689


<210>  9298
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__A4D2P0

<400>  9298

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Val Gly Glu Thr Tyr 
65                  70                  75                  80  


Gly Lys Asp Ile Thr Ser Arg Gly Lys Asp Lys Pro Ile Ala Asp Val 
                85                  90                  95      


Phe Leu Ile Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val 
            100                 105                 110         


Arg Ala Lys Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro 
        115                 120                 125             


Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr 
    130                 135                 140                 


Ile Glu Lys Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln 
145                 150                 155                 160 


Gly Leu Ala Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys 
                165                 170                 175     


Ser Ala Leu Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile 
            180                 185                 190         


Arg Ala Val Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys 
        195                 200                 205             


Leu Leu Leu 
    210     


<210>  9299
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__BAF84504

<400>  9299
augcaggcca ucaagugugu ggugguggga gacggagcug uagguaaaac uugccuacug       60

aucaguuaca caaccaaugc auuuccugga gaauauaucc cuacugucuu ugacaauuau      120

ucugccaaug uuaugguaga uggaaaaccg gugaaucugg gcuuauggga uacagcugga      180

caagaagauu augacagauu acgcccccua uccuauccgc aaacaguugg agaaacguac      240

gguaaggaua uaaccucccg gggcaaagac aagccgauug ccgauguguu cuuaauuugc      300

uuuucccuug ugaguccugc aucauuugaa aauguccgug caaaguggua uccugaggug      360

cggcaccacu gucccaacac ucccaucauc cuagugggaa cuaaacuuga ucuuagggau      420

gauaaagaca cgaucgagaa acugaaggag aagaagcuga cucccaucac cuauccgcag      480

ggucuagcca uggcuaagga gauuggugcu guaaaauacc uggagugcuc ggcgcucaca      540

cagcgaggcc ucaagacagu guuugacgaa gcgauccgag caguccucug cccgccuccc      600

gugaagaaga ggaagagaaa augccugcug uuguaa                                636


<210>  9300
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rac1__Homo_sapiens__BAF84504

<400>  9300
augcaggcca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca ccacgaacgc guuccccggg gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ugauggugga cggcaagccc gucaaccugg ggcuguggga caccgccggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccguggg cgagacguac      240

gggaaggaca ucaccucccg cggcaaggac aagccgaucg ccgacguguu ccugaucugc      300

uucagccucg ucucccccgc cagcuucgag aacgugcggg cgaaguggua ccccgaggug      360

cgccaccacu gccccaacac cccgaucauc cuggucggga ccaagcugga ccuccgggac      420

gacaaggaca cgaucgagaa gcugaaggag aagaagcuga cccccaucac cuacccccag      480

ggccucgcca uggccaagga gaucggggcc gugaaguacc uggagugcuc cgcgcugacc      540

cagcgcggcc ucaagacggu guucgacgag gccauccggg ccguccugug cccgccgccc      600

gugaagaagc gcaagcggaa gugccugcuc cuguga                                636


<210>  9301
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rac1__Homo_sapiens__BAF84504

<400>  9301
augcaggcca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacgc cuuccccggc gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ucauggucga cggcaagccc gucaaccucg gccucuggga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgucgg cgagaccuac      240

ggcaaggaca ucaccucccg cggcaaggac aagcccaucg ccgacgucuu ccucaucugc      300

uucucccucg ucucccccgc cuccuucgag aacguccgcg ccaaguggua ccccgagguc      360

cgccaccacu gccccaacac ccccaucauc cucgucggca ccaagcucga ccuccgcgac      420

gacaaggaca ccaucgagaa gcucaaggag aagaagcuca cccccaucac cuacccccag      480

ggccucgcca uggccaagga gaucggcgcc gucaaguacc ucgagugcuc cgcccucacc      540

cagcgcggcc ucaagaccgu cuucgacgag gccauccgcg ccguccucug cccccccccc      600

gucaagaagc gcaagcgcaa gugccuccuc cucuga                                636


<210>  9302
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rac1__Homo_sapiens__BAF84504

<400>  9302
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacuaacgc auuccccggu gaguauauac cuacgguauu ugauaauuac      120

uccgccaacg ugauggucga cggcaagcca gugaaucuug ggcuguggga uaccgcggga      180

caagaagacu augauagauu gaggccguua ucuuaccccc agacaguugg cgagacuuau      240

gguaaagaca ucaccucacg ggggaaggau aaaccuauug cugacguguu ccugaucugc      300

uuuagucuag ucagcccagc cuccuucgaa aacgugcgcg caaaguggua ccccgaggua      360

cgacaccauu guccuaauac accaauuauc cucguuggaa ccaagcugga ucuucgugac      420

gauaaagaca cuauagaaaa gcugaaagag aagaaauuga cacccaucac cuauccucag      480

ggccucgcca uggcuaagga gauuggcgca gugaaguacc uggaaugcuc ugcccugacg      540

cagagagggc ucaaaacugu cuuugaugag gcuaucaggg ccguguuaug uccaccgccc      600

gugaagaaac ggaagcgcaa augccugcuu uuguga                                636


<210>  9303
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rac1__Homo_sapiens__BAF84504

<400>  9303
augcaggcca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacgc cuuccccggc gaguacaucc ccaccguguu cgacaacuac      120

agcgccaacg ugauggugga cggcaagccc gugaaccugg gccuguggga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccguggg cgagaccuac      240

ggcaaggaca ucaccagcag aggcaaggac aagcccaucg ccgacguguu ccugaucugc      300

uucagccugg ugagccccgc cagcuucgag aacgugagag ccaaguggua ccccgaggug      360

agacaccacu gccccaacac ccccaucauc cuggugggca ccaagcugga ccugagagac      420

gacaaggaca ccaucgagaa gcugaaggag aagaagcuga cccccaucac cuacccccag      480

ggccuggcca uggccaagga gaucggcgcc gugaaguacc uggagugcag cgcccugacc      540

cagagaggcc ugaagaccgu guucgacgag gccaucagag ccgugcugug cccccccccc      600

gugaagaaga gaaagagaaa gugccugcug cuguga                                636


<210>  9304
<211>  636
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rac1__Homo_sapiens__BAF84504

<400>  9304
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacgaacgc cuuccccggc gaguauaucc cuaccguguu ugauaauuac      120

uccgcgaacg ucauggugga cgggaagccg guuaaucugg gacuuuggga uacagcuggc      180

caagaagacu augauagacu gcggccccuc ucuuacccuc agaccguggg ggagacauau      240

ggaaaagaca uuaccagccg cggcaaggau aaacccaucg ccgacgucuu ccugauuugc      300

uuuucccuug ugucuccugc cagcuucgaa aacguuagag cuaaguggua ccccgaggug      360

cggcaccauu guccuaauac accgaucauc cuggucggca ccaagcucga ucugcgcgac      420

gauaaagaca cgauugaaaa gcugaaagag aagaaacuca cccccaucac auauccucag      480

gggcuggcca uggcuaagga gauuggagcc gugaaguacc uugaaugcuc cgcgcugacc      540

cagagaggcc ucaaaacagu guuugaugag gccauccggg cuguccugug ucccccuccc      600

guuaagaaac gcaagagaaa augccuucug cucuga                                636


<210>  9305
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__A4D2P1

<400>  9305

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190         






<210>  9306
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__BAF84495

<400>  9306
augcaggcca ucaagugugu ggugguggga gacggagcug uagguaaaac uugccuacug       60

aucaguuaca caaccaaugc auuuccugga gaauauaucc cuacugucuu ugacaauuau      120

ucugccaaug uuaugguaga uggaaaaccg gugaaucugg gcuuauggga uacagcugga      180

caagaagauu augacagauu acgcccccua uccuauccgc aaacagaugu guucuuaauu      240

ugcuuuuccc uugugagucc ugcaucauuu gaaaaugucc gugcaaagug guauccugag      300

gugcggcacc acugucccaa cacucccauc auccuagugg gaacuaaacu ugaucuuagg      360

gaugauaaag acacgaucga gaaacugaag gagaagaagc ugacucccau caccuauccg      420

cagggucuag ccauggcuaa ggagauuggu gcuguaaaau accuggagug cucggcgcuc      480

acacagcgag gccucaagac aguguuugac gaagcgaucc gagcaguccu cugcccgccu      540

cccgugaaga agaggaagag aaaaugccug cuguuguaa                             579


<210>  9307
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rac1__Homo_sapiens__BAF84495

<400>  9307
augcaggcca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca ccacgaacgc guuccccggg gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ugauggugga cggcaagccc gucaaccugg ggcuguggga caccgccggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccgacgu guuccugauc      240

ugcuucuccc ucgugagccc ggccuccuuc gagaacgucc gcgccaagug guaccccgag      300

gugcggcacc acugccccaa cacgcccauc auccuggugg gcaccaagcu ggaccuccgc      360

gacgacaagg acaccaucga gaagcugaag gagaagaagc ugaccccgau cacguacccc      420

caggggcucg cgauggccaa ggagaucggc gccgucaagu accuggagug cagcgcccug      480

acccagcggg ggcucaagac cguguucgac gaggcgaucc gcgccgugcu gugcccgccg      540

cccgucaaga agcggaagcg caagugccug cuccuguga                             579


<210>  9308
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rac1__Homo_sapiens__BAF84495

<400>  9308
augcaggcca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacgc cuuccccggc gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ucauggucga cggcaagccc gucaaccucg gccucuggga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgacgu cuuccucauc      240

ugcuucuccc ucgucucccc cgccuccuuc gagaacgucc gcgccaagug guaccccgag      300

guccgccacc acugccccaa cacccccauc auccucgucg gcaccaagcu cgaccuccgc      360

gacgacaagg acaccaucga gaagcucaag gagaagaagc ucacccccau caccuacccc      420

cagggccucg ccauggccaa ggagaucggc gccgucaagu accucgagug cuccgcccuc      480

acccagcgcg gccucaagac cgucuucgac gaggccaucc gcgccguccu cugccccccc      540

cccgucaaga agcgcaagcg caagugccuc cuccucuga                             579


<210>  9309
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rac1__Homo_sapiens__BAF84495

<400>  9309
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacuaacgc auuccccggu gaguauauac cuacgguauu ugauaauuac      120

uccgccaacg ugauggucga cggcaagcca gugaaucuug ggcuguggga uaccgcggga      180

caagaagacu augauagauu gaggccguua ucuuaccccc agacagacgu uuuccugauc      240

ugcuuuucac ucgugagucc ugcuagcuuc gagaacgucc gggccaaaug guauccagaa      300

gugcgccacc auugucccaa uacuccuauu auccuaguag gcaccaagcu ggaucuucga      360

gacgauaaag acacaauuga gaagcugaag gagaaaaagu ugaccccaau cacuuacccc      420

cagggucucg caauggccaa agaaauaggg gcuguuaagu aucuggagug cuccgcacug      480

acacagcgug gacucaaaac cguguuugau gaagccauca gagcugucuu auguccucca      540

ccggugaaga agaggaaacg gaagugccug cuuuuguga                             579


<210>  9310
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rac1__Homo_sapiens__BAF84495

<400>  9310
augcaggcca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacgc cuuccccggc gaguacaucc ccaccguguu cgacaacuac      120

agcgccaacg ugauggugga cggcaagccc gugaaccugg gccuguggga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccgacgu guuccugauc      240

ugcuucagcc uggugagccc cgccagcuuc gagaacguga gagccaagug guaccccgag      300

gugagacacc acugccccaa cacccccauc auccuggugg gcaccaagcu ggaccugaga      360

gacgacaagg acaccaucga gaagcugaag gagaagaagc ugacccccau caccuacccc      420

cagggccugg ccauggccaa ggagaucggc gccgugaagu accuggagug cagcgcccug      480

acccagagag gccugaagac cguguucgac gaggccauca gagccgugcu gugccccccc      540

cccgugaaga agagaaagag aaagugccug cugcuguga                             579


<210>  9311
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rac1__Homo_sapiens__BAF84495

<400>  9311
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacgaacgc cuuccccggc gaguauaucc cuaccguguu ugauaauuac      120

uccgcgaacg ucauggugga cgggaagccg guuaaucugg gacuuuggga uacagcuggc      180

caagaagacu augauagacu gcggccccuc ucuuacccuc agaccgacgu guuccugauu      240

ugcuuuagcc uugucucccc cgccucuuuc gagaacgugc gcgccaaaug guauccugaa      300

guuagacacc auugucccaa uacaccuauc auucuggugg ggaccaagcu cgaucugcgg      360

gacgauaaag acacaaucga gaagcugaag gagaaaaagc ucaccccgau cacguacccc      420

cagggacugg cuauggccaa agaaauuggc gcugucaagu aucuugagug cagcgcccug      480

acccagcgcg gccucaaaac aguguuugau gaagcgauca gagccgugcu guguccuccc      540

ccugucaaga agcggaaacg caagugccuu cugcucuga                             579


<210>  9312
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__A4D2P2

<400>  9312

Met Val Asp Gly Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly 
1               5                   10                  15      


Gln Glu Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp 
            20                  25                  30          


Val Phe Leu Ile Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn 
        35                  40                  45              


Val Arg Ala Lys Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr 
    50                  55                  60                  


Pro Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp 
65                  70                  75                  80  


Thr Ile Glu Lys Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro 
                85                  90                  95      


Gln Gly Leu Ala Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu 
            100                 105                 110         


Cys Ser Ala Leu Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala 
        115                 120                 125             


Ile Arg Ala Val Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys 
    130                 135                 140                 


Cys Leu Leu Leu 
145             


<210>  9313
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__EAL23720

<400>  9313
augguagaug gaaaaccggu gaaucugggc uuaugggaua cagcuggaca agaagauuau       60

gacagauuac gcccccuauc cuauccgcaa acagaugugu ucuuaauuug cuuuucccuu      120

gugaguccug caucauuuga aaauguccgu gcaaaguggu auccugaggu gcggcaccac      180

ugucccaaca cucccaucau ccuaguggga acuaaacuug aucuuaggga ugauaaagac      240

acgaucgaga aacugaagga gaagaagcug acucccauca ccuauccgca gggucuagcc      300

auggcuaagg agauuggugc uguaaaauac cuggagugcu cggcgcucac acagcgaggc      360

cucaagacag uguuugacga agcgauccga gcaguccucu gcccgccucc cgugaagaag      420

aggaagagaa aaugccugcu guuguaa                                          447


<210>  9314
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rac1__Homo_sapiens__EAL23720

<400>  9314
augguggacg gcaagcccgu caaccugggg cucugggaca ccgccggcca ggaggacuac       60

gaccgccugc ggccccugag cuacccccag accgacgugu uccucaucug cuucucccug      120

gugagccccg ccuccuucga gaacguccgc gcgaaguggu accccgaggu gcggcaccac      180

ugcccgaaca cgcccaucau ccuggugggg accaagcucg accugcgcga cgacaaggac      240

accaucgaga agcugaagga gaagaagcuc acccccauca cguaccccca gggccuggcc      300

auggccaagg agaucggggc cgucaaguac cuggagugca gcgcccucac ccagcggggc      360

cugaagaccg uguucgacga ggcgauccgc gccgugcugu gcccgccgcc cgucaagaag      420

cggaagcgca agugccuccu gcuguga                                          447


<210>  9315
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rac1__Homo_sapiens__EAL23720

<400>  9315
auggucgacg gcaagcccgu caaccucggc cucugggaca ccgccggcca ggaggacuac       60

gaccgccucc gcccccucuc cuacccccag accgacgucu uccucaucug cuucucccuc      120

gucucccccg ccuccuucga gaacguccgc gccaaguggu accccgaggu ccgccaccac      180

ugccccaaca cccccaucau ccucgucggc accaagcucg accuccgcga cgacaaggac      240

accaucgaga agcucaagga gaagaagcuc acccccauca ccuaccccca gggccucgcc      300

auggccaagg agaucggcgc cgucaaguac cucgagugcu ccgcccucac ccagcgcggc      360

cucaagaccg ucuucgacga ggccauccgc gccguccucu gccccccccc cgucaagaag      420

cgcaagcgca agugccuccu ccucuga                                          447


<210>  9316
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rac1__Homo_sapiens__EAL23720

<400>  9316
augguggacg gcaagcccgu caaccugggg cucugggaua ccgccggaca ggaggacuac       60

gauagacuua ggccucugag cuauccacaa acagacguuu ucuugaucug cuuuuccuua      120

gugucuccgg cuucauucga aaauguacgg gcaaaauggu accccgaggu gcgccaccau      180

uguccuaaca cuccaauuau acuggucggu acgaagcuag aucuccgaga cgauaaagac      240

accaucgaaa agcugaaaga gaagaaacuu acacccauua cuuauccuca gggccuggcc      300

auggcgaagg aaaucggggc ugugaaguac uuggagugca gugcccucac ccagcgugga      360

cugaaaacag uuuuugauga ggcaauuaga gccgugcugu guccaccccc ugucaagaaa      420

aggaagcgga agugccucuu acuguga                                          447


<210>  9317
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rac1__Homo_sapiens__EAL23720

<400>  9317
augguggacg gcaagcccgu gaaccugggc cugugggaca ccgccggcca ggaggacuac       60

gacagacuga gaccccugag cuacccccag accgacgugu uccugaucug cuucagccug      120

gugagccccg ccagcuucga gaacgugaga gccaaguggu accccgaggu gagacaccac      180

ugccccaaca cccccaucau ccuggugggc accaagcugg accugagaga cgacaaggac      240

accaucgaga agcugaagga gaagaagcug acccccauca ccuaccccca gggccuggcc      300

auggccaagg agaucggcgc cgugaaguac cuggagugca gcgcccugac ccagagaggc      360

cugaagaccg uguucgacga ggccaucaga gccgugcugu gccccccccc cgugaagaag      420

agaaagagaa agugccugcu gcuguga                                          447


<210>  9318
<211>  447
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rac1__Homo_sapiens__EAL23720

<400>  9318
augguggacg gcaagcccgu caaccugggg cucugggaua ccgccggaca ggaggacuac       60

gauagacugc ggccucuuag cuauccgcaa acagacguuu uccugaucug cuuuucccuc      120

gugucucccg cuagcuucga aaaugugcgc gccaaauggu acccugaggu cagacaccau      180

ugucccaaca cgccuauuau ccuggugggc accaaacuug aucugcggga cgauaaggac      240

acaauugaaa agcucaaaga gaagaagcug acccccauca cauauccuca ggggcuggcg      300

auggcuaaag aaauuggagc cguuaaguac cucgagugcu ccgcccugac ccagcgcggc      360

cuuaaaacag uguuugauga ggcuaucaga gccguccugu guccgccccc ugugaagaaa      420

cggaagcgca agugccuccu gcuuuga                                          447


<210>  9319
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__P63000

<400>  9319

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190         






<210>  9320
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__AAA36537

<400>  9320
augcaggcca ucaagugugu ggugguggga gacggagcug uagguaaaac uugccuacug       60

aucaguuaca caaccaaugc auuuccugga gaauauaucc cuacugucuu ugacaauuau      120

ucugccaaug uuaugguaga uggaaaaccg gugaaucugg gcuuauggga uacagcugga      180

caagaagauu augacagauu acgcccccua uccuauccgc aaacagaugu guucuuaauu      240

ugcuuuuccc uugugagucc ugcaucauuu gaaaaugucc gugcaaagug guauccugag      300

gugcggcacc acugucccaa cacucccauc auccuagugg gaacuaaacu ugaucuuagg      360

gaugauaaag acacgaucga gaaacugaag gagaagaagc ugacucccau caccuauccg      420

cagggucuag ccauggcuaa ggagauuggu gcuguaaaau accuggagug cucggcgcuc      480

acacagcgag gccucaagac aguguuugac gaagcgaucc gagcaguccu cugcccgccu      540

cccgugaaga agaggaagag aaaaugccug cuguuguaa                             579


<210>  9321
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rac1__Homo_sapiens__AAA36537

<400>  9321
augcaggcca ucaagugcgu ggucgugggc gacggggccg ugggcaagac cugccugcuc       60

aucagcuaca ccacgaacgc guuccccggg gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ugauggugga cggcaagccc gucaaccugg ggcuguggga caccgccggc      180

caggaggacu acgaccgccu ccggccccug agcuaccccc agaccgacgu guuccugauc      240

ugcuucuccc ucgugagccc ggccuccuuc gagaacgucc gcgccaagug guaccccgag      300

gugcggcacc acugccccaa cacgcccauc auccuggugg gcaccaagcu ggaccuccgc      360

gacgacaagg acaccaucga gaagcugaag gagaagaagc ugaccccgau cacguacccc      420

caggggcucg cgauggccaa ggagaucggc gccgucaagu accuggagug cagcgcccug      480

acccagcggg ggcucaagac cguguucgac gaggcgaucc gcgccgugcu gugcccgccg      540

cccgucaaga agcggaagcg caagugccug cuccuguga                             579


<210>  9322
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rac1__Homo_sapiens__AAA36537

<400>  9322
augcaggcca ucaagugcgu cgucgucggc gacggcgccg ucggcaagac cugccuccuc       60

aucuccuaca ccaccaacgc cuuccccggc gaguacaucc ccaccgucuu cgacaacuac      120

uccgccaacg ucauggucga cggcaagccc gucaaccucg gccucuggga caccgccggc      180

caggaggacu acgaccgccu ccgcccccuc uccuaccccc agaccgacgu cuuccucauc      240

ugcuucuccc ucgucucccc cgccuccuuc gagaacgucc gcgccaagug guaccccgag      300

guccgccacc acugccccaa cacccccauc auccucgucg gcaccaagcu cgaccuccgc      360

gacgacaagg acaccaucga gaagcucaag gagaagaagc ucacccccau caccuacccc      420

cagggccucg ccauggccaa ggagaucggc gccgucaagu accucgagug cuccgcccuc      480

acccagcgcg gccucaagac cgucuucgac gaggccaucc gcgccguccu cugccccccc      540

cccgucaaga agcgcaagcg caagugccuc cuccucuga                             579


<210>  9323
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rac1__Homo_sapiens__AAA36537

<400>  9323
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacuaacgc auuccccggu gaguauauac cuacgguauu ugauaauuac      120

uccgccaacg ugauggucga cggcaagcca gugaaucuug ggcuguggga uaccgcggga      180

caagaagacu augauagauu gaggccguua ucuuaccccc agacagacgu uuuccugauc      240

ugcuuuucac ucgugagucc ugcuagcuuc gagaacgucc gggccaaaug guauccagaa      300

gugcgccacc auugucccaa uacuccuauu auccuaguag gcaccaagcu ggaucuucga      360

gacgauaaag acacaauuga gaagcugaag gagaaaaagu ugaccccaau cacuuacccc      420

cagggucucg caauggccaa agaaauaggg gcuguuaagu aucuggagug cuccgcacug      480

acacagcgug gacucaaaac cguguuugau gaagccauca gagcugucuu auguccucca      540

ccggugaaga agaggaaacg gaagugccug cuuuuguga                             579


<210>  9324
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rac1__Homo_sapiens__AAA36537

<400>  9324
augcaggcca ucaagugcgu gguggugggc gacggcgccg ugggcaagac cugccugcug       60

aucagcuaca ccaccaacgc cuuccccggc gaguacaucc ccaccguguu cgacaacuac      120

agcgccaacg ugauggugga cggcaagccc gugaaccugg gccuguggga caccgccggc      180

caggaggacu acgacagacu gagaccccug agcuaccccc agaccgacgu guuccugauc      240

ugcuucagcc uggugagccc cgccagcuuc gagaacguga gagccaagug guaccccgag      300

gugagacacc acugccccaa cacccccauc auccuggugg gcaccaagcu ggaccugaga      360

gacgacaagg acaccaucga gaagcugaag gagaagaagc ugacccccau caccuacccc      420

cagggccugg ccauggccaa ggagaucggc gccgugaagu accuggagug cagcgcccug      480

acccagagag gccugaagac cguguucgac gaggccauca gagccgugcu gugccccccc      540

cccgugaaga agagaaagag aaagugccug cugcuguga                             579


<210>  9325
<211>  579
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rac1__Homo_sapiens__AAA36537

<400>  9325
augcaggcca ucaagugcgu ggucguuggc gacggggcug ugggaaaaac cugucugcuc       60

auuagcuaca caacgaacgc cuuccccggc gaguauaucc cuaccguguu ugauaauuac      120

uccgcgaacg ucauggugga cgggaagccg guuaaucugg gacuuuggga uacagcuggc      180

caagaagacu augauagacu gcggccccuc ucuuacccuc agaccgacgu guuccugauu      240

ugcuuuagcc uugucucccc cgccucuuuc gagaacgugc gcgccaaaug guauccugaa      300

guuagacacc auugucccaa uacaccuauc auucuggugg ggaccaagcu cgaucugcgg      360

gacgauaaag acacaaucga gaagcugaag gagaaaaagc ucaccccgau cacguacccc      420

cagggacugg cuauggccaa agaaauuggc gcugucaagu aucuugagug cagcgcccug      480

acccagcgcg gccucaaaac aguguuugau gaagcgauca gagccgugcu guguccuccc      540

ccugucaaga agcggaaacg caagugccuu cugcucuga                             579


<210>  9326
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__W0UV93

<400>  9326

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210>  9327
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Rac1__Homo_sapiens__CDG31913

<400>  9327
auggcucugg agaagucucu uguccggcuc cuucugcuug uccugauacu gcuggugcug       60

ggcugggucc agccuucccu gggcaaggaa ucccgggcca agaaauucca gcggcagcau      120

auggacucag acaguucccc cagcagcagc uccaccuacu guaaccaaau gaugaggcgc      180

cggaauauga cacaggggcg gugcaaacca gugaacaccu uugugcacga gccccuggua      240

gauguccaga augucuguuu ccaggaaaag gucaccugca agaacgggca gggcaacugc      300

uacaagagca acuccagcau gcacaucaca gacugccgcc ugacaaacgg cuccagguac      360

cccaacugug cauaccggac cagcccgaag gagagacaca ucauuguggc cugugaaggg      420

agcccauaug ugccagucca cuuugaugcu ucuguggagg acucuaccua a               471


<210>  9328
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Rac1__Homo_sapiens__CDG31913

<400>  9328
auggcccugg agaagucccu cgugcgccug cugcuccugg uccugauccu ccuggugcug       60

ggcugggugc agcccagccu cgggaaggag agccgggcca agaaguucca gcgccagcac      120

auggacuccg acagcucccc gagcuccagc uccaccuacu gcaaccagau gaugcggcgc      180

cggaacauga cccagggccg cugcaagccc gucaacacgu ucgugcacga gccccuggug      240

gacguccaga acgugugcuu ccaggagaag gugaccugca agaacgggca gggcaacugc      300

uacaagagca acuccagcau gcacaucacc gacugccggc ugaccaacgg gucccgcuac      360

cccaacugcg cguaccggac gagcccgaag gagcgccaca ucaucgucgc cugcgagggc      420

ucccccuacg ugcccgugca cuucgacgcc agcgucgagg acuccaccug a               471


<210>  9329
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Rac1__Homo_sapiens__CDG31913

<400>  9329
auggcccucg agaagucccu cguccgccuc cuccuccucg uccucauccu ccucguccuc       60

ggcugggucc agcccucccu cggcaaggag ucccgcgcca agaaguucca gcgccagcac      120

auggacuccg acuccucccc cuccuccucc uccaccuacu gcaaccagau gaugcgccgc      180

cgcaacauga cccagggccg cugcaagccc gucaacaccu ucguccacga gccccucguc      240

gacguccaga acgucugcuu ccaggagaag gucaccugca agaacggcca gggcaacugc      300

uacaagucca acuccuccau gcacaucacc gacugccgcc ucaccaacgg cucccgcuac      360

cccaacugcg ccuaccgcac cucccccaag gagcgccaca ucaucgucgc cugcgagggc      420

ucccccuacg uccccgucca cuucgacgcc uccgucgagg acuccaccug a               471


<210>  9330
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Rac1__Homo_sapiens__CDG31913

<400>  9330
auggcccugg aaaagagccu cgugagacuu cuguuguuag uccugauccu acucguucug       60

ggcugggugc agcccucccu ugggaaagag ucuagggcua agaaauucca acggcagcac      120

auggacucag auaguagccc uuccucuucg ucaaccuacu gcaaccagau gaugcgccga      180

cguaauauga cacagggaag auguaagcca guaaacacuu uugugcauga gccgcugguc      240

gacgugcaaa auguuugcuu ccaggaaaaa gugacgugua agaacgguca gggcaauugc      300

uauaagagca acaguuccau gcacauuacc gauuguaggu ugacaaaugg gucucgguac      360

cccaacugcg cauaucgcac uagcccuaaa gagagacaua uaaucgucgc cugugaagga      420

uccccauacg ugcccguaca cuuugacgcg ucaguugagg auaguaccug a               471


<210>  9331
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Rac1__Homo_sapiens__CDG31913

<400>  9331
auggcccugg agaagagccu ggugagacug cugcugcugg ugcugauccu gcuggugcug       60

ggcugggugc agcccagccu gggcaaggag agcagagcca agaaguucca gagacagcac      120

auggacagcg acagcagccc cagcagcagc agcaccuacu gcaaccagau gaugagaaga      180

agaaacauga cccagggcag augcaagccc gugaacaccu ucgugcacga gccccuggug      240

gacgugcaga acgugugcuu ccaggagaag gugaccugca agaacggcca gggcaacugc      300

uacaagagca acagcagcau gcacaucacc gacugcagac ugaccaacgg cagcagauac      360

cccaacugcg ccuacagaac cagccccaag gagagacaca ucaucguggc cugcgagggc      420

agccccuacg ugcccgugca cuucgacgcc agcguggagg acagcaccug a               471


<210>  9332
<211>  471
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Rac1__Homo_sapiens__CDG31913

<400>  9332
auggcccugg aaaagagccu cgugagacug cuucugcucg uccugauccu ucugguucuc       60

ggcugggugc agcccucccu ggggaaagag ucucgggcua agaaauucca acgccagcac      120

auggacagcg auuccucucc uagcuccucu agcaccuacu gcaaccagau gaugagacgg      180

cgcaauauga cacagggaag auguaagccg gugaacacgu uuguccauga gccccuggug      240

gacguucaaa augugugcuu ccaggaaaaa gucaccugua agaacggcca ggggaauugc      300

uauaagucca acagcucuau gcacauuaca gauugucggc ucaccaaugg aucccgcuac      360

ccuaacugcg ccuauagaac aagccccaaa gagcggcaua ucauuguggc gugugaaggc      420

ucuccuuacg uucccgugca cuuugacgcu uccgucgagg auagcaccug a               471


<210>  9333
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RhoA__Homo_sapiens__A0A024R324

<400>  9333

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  9334
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RhoA__Homo_sapiens__EAW64978

<400>  9334
auggcugcca uccggaagaa acuggugauu guuggugaug gagccugugg aaagacaugc       60

uugcucauag ucuucagcaa ggaccaguuc ccagaggugu augugcccac aguguuugag      120

aacuaugugg cagauaucga gguggaugga aagcagguag aguuggcuuu gugggacaca      180

gcugggcagg aagauuauga ucgccugagg ccccucuccu acccagauac cgauguuaua      240

cugauguguu uuuccaucga cagcccugau aguuuagaaa acaucccaga aaaguggacc      300

ccagaaguca agcauuucug ucccaacgug cccaucaucc ugguugggaa uaagaaggau      360

cuucggaaug augagcacac aaggcgggag cuagccaaga ugaagcagga gccggugaaa      420

ccugaagaag gcagagauau ggcaaacagg auuggcgcuu uuggguacau ggaguguuca      480

gcaaagacca aagauggagu gagagagguu uuugaaaugg cuacgagagc ugcucugcaa      540

gcuagacgug ggaagaaaaa aucugggugc cuugucuugu ga                         582


<210>  9335
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RhoA__Homo_sapiens__EAW64978

<400>  9335
auggccgcca uccgcaagaa gcuggugauc gucggcgacg gggcgugcgg caagaccugc       60

cuccugaucg uguucagcaa ggaccaguuc cccgaggugu acgucccgac cguguucgag      120

aacuacgugg ccgacaucga ggucgacggg aagcaggucg agcuggcccu cugggacacg      180

gccggccagg aggacuacga ccggcugcgc ccccugagcu accccgacac cgacgugauc      240

cucaugugcu ucagcaucga cucccccgac agccuggaga acaucccgga gaaguggacc      300

cccgagguga agcacuucug ccccaacgug cccaucaucc ugguggggaa caagaaggac      360

cuccggaacg acgagcacac ccgccgggag cuggccaaga ugaagcagga gccggucaag      420

cccgaggagg gccgcgacau ggcgaaccgg aucggcgccu ucggguacau ggagugcucc      480

gccaagacga aggacggcgu gcgcgaggug uucgagaugg ccacccgggc ggcccugcag      540

gcccgccggg ggaagaagaa guccggcugc cucguccugu ga                         582


<210>  9336
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RhoA__Homo_sapiens__EAW64978

<400>  9336
auggccgcca uccgcaagaa gcucgucauc gucggcgacg gcgccugcgg caagaccugc       60

cuccucaucg ucuucuccaa ggaccaguuc cccgaggucu acguccccac cgucuucgag      120

aacuacgucg ccgacaucga ggucgacggc aagcaggucg agcucgcccu cugggacacc      180

gccggccagg aggacuacga ccgccuccgc ccccucuccu accccgacac cgacgucauc      240

cucaugugcu ucuccaucga cucccccgac ucccucgaga acauccccga gaaguggacc      300

cccgagguca agcacuucug ccccaacguc cccaucaucc ucgucggcaa caagaaggac      360

cuccgcaacg acgagcacac ccgccgcgag cucgccaaga ugaagcagga gcccgucaag      420

cccgaggagg gccgcgacau ggccaaccgc aucggcgccu ucggcuacau ggagugcucc      480

gccaagacca aggacggcgu ccgcgagguc uucgagaugg ccacccgcgc cgcccuccag      540

gcccgccgcg gcaagaagaa guccggcugc cucguccucu ga                         582


<210>  9337
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RhoA__Homo_sapiens__EAW64978

<400>  9337
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggcaugcgg aaagaccugu       60

cuccuuauag uuuucagcaa agaucaguuu cccgaggugu acguaccuac aguguucgaa      120

aacuaugucg ccgacaucga gguggauggu aagcaaguug aacuggcguu gugggacacu      180

gcuggccagg aggauuacga cagguuacgg ccacuguccu auccggauac ggacgugauu      240

cuaaugugcu uuucuaucga uucacccgac agucucgaaa auauuccuga gaaauggacc      300

ccagagguca agcacuucug ucccaacgug ccuaucauac ugguagggaa uaagaaagau      360

cuucgcaacg acgaacauac acgacgugag cuggccaaga ugaaacagga accaguuaag      420

cccgaggagg gaagagauau ggcaaauagg aucggcgccu uugguuacau ggaaugcagc      480

gcuaaaacua aggacggggu gcgggagguc uucgaaaugg caacccgcgc cgcuuugcag      540

gccagaaggg gaaagaaaaa guccggcugu cucgugcugu ga                         582


<210>  9338
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RhoA__Homo_sapiens__EAW64978

<400>  9338
auggccgcca ucagaaagaa gcuggugauc gugggcgacg gcgccugcgg caagaccugc       60

cugcugaucg uguucagcaa ggaccaguuc cccgaggugu acgugcccac cguguucgag      120

aacuacgugg ccgacaucga gguggacggc aagcaggugg agcuggcccu gugggacacc      180

gccggccagg aggacuacga cagacugaga ccccugagcu accccgacac cgacgugauc      240

cugaugugcu ucagcaucga cagccccgac agccuggaga acauccccga gaaguggacc      300

cccgagguga agcacuucug ccccaacgug cccaucaucc uggugggcaa caagaaggac      360

cugagaaacg acgagcacac cagaagagag cuggccaaga ugaagcagga gcccgugaag      420

cccgaggagg gcagagacau ggccaacaga aucggcgccu ucggcuacau ggagugcagc      480

gccaagacca aggacggcgu gagagaggug uucgagaugg ccaccagagc cgcccugcag      540

gccagaagag gcaagaagaa gagcggcugc cuggugcugu ga                         582


<210>  9339
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RhoA__Homo_sapiens__EAW64978

<400>  9339
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggccugcgg aaagaccugu       60

cuccugaucg uuuucagcaa agaucaguuu cccgaggugu acgugccuac agucuucgaa      120

aacuaugugg cggacauuga gguugauggc aagcaagugg aacuugcucu gugggacacg      180

gccgggcagg aggauuacga ccggcuccgc ccgcuguccu aucccgauac cgacgucauc      240

cuuaugugcu uuucuauuga uagcccugac ucccuggaaa auauccccga gaaauggaca      300

ccugagguga agcacuucug ucccaacguu ccuaucauuc ucgugggaaa uaagaaagau      360

cugagaaacg acgaacauac ccggcgcgag cuggccaaga ugaaacagga accggucaag      420

cccgaggagg gcagagauau ggcuaaucgg aucggggccu uuggauacau ggaaugcucu      480

gcuaaaacaa aggacggcgu gcgcgaggug uucgaaaugg ccaccagagc ggcccuccag      540

gcucggcgcg gcaagaaaaa gagcgggugu cugguccuuu ga                         582


<210>  9340
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RhoA__Homo_sapiens__P61586

<400>  9340

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  9341
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RhoA__Homo_sapiens__AAC33178

<400>  9341
auggcugcca uccggaagaa acuggugauu guuggugaug gagccugugg aaagacaugc       60

uugcucauag ucuucagcaa ggaccaguuc ccagaggugu augugcccac aguguuugag      120

aacuaugugg cagauaucga gguggaugga aagcagguag aguuggcuuu gugggacaca      180

gcugggcagg aagauuauga ucgccugagg ccccucuccu acccagauac cgauguuaua      240

cugauguguu uuuccaucga cagcccugau aguuuagaaa acaucccaga aaaguggacc      300

ccagaaguca agcauuucug ucccaacgug cccaucaucc ugguugggaa uaagaaggau      360

cuucggaaug augagcacac aaggcgggag cuagccaaga ugaagcagga gccggugaaa      420

ccugaagaag gcagagauau ggcaaacagg auuggcgcuu uuggguacau ggaguguuca      480

gcaaagacca aagauggagu gagagagguu uuugaaaugg cuacgagagc ugcucugcaa      540

gcuagacgug ggaagaaaaa aucugguugc cuugucuugu ga                         582


<210>  9342
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RhoA__Homo_sapiens__AAC33178

<400>  9342
auggccgcca uccgcaagaa gcuggugauc gucggcgacg gggcgugcgg caagaccugc       60

cuccugaucg uguucagcaa ggaccaguuc cccgaggugu acgucccgac cguguucgag      120

aacuacgugg ccgacaucga ggucgacggg aagcaggucg agcuggcccu cugggacacg      180

gccggccagg aggacuacga ccggcugcgc ccccugagcu accccgacac cgacgugauc      240

cucaugugcu ucagcaucga cucccccgac agccuggaga acaucccgga gaaguggacc      300

cccgagguga agcacuucug ccccaacgug cccaucaucc ugguggggaa caagaaggac      360

cuccggaacg acgagcacac ccgccgggag cuggccaaga ugaagcagga gccggucaag      420

cccgaggagg gccgcgacau ggcgaaccgg aucggcgccu ucggguacau ggagugcucc      480

gccaagacga aggacggcgu gcgcgaggug uucgagaugg ccacccgggc ggcccugcag      540

gcccgccggg ggaagaagaa guccggcugc cucguccugu ga                         582


<210>  9343
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RhoA__Homo_sapiens__AAC33178

<400>  9343
auggccgcca uccgcaagaa gcucgucauc gucggcgacg gcgccugcgg caagaccugc       60

cuccucaucg ucuucuccaa ggaccaguuc cccgaggucu acguccccac cgucuucgag      120

aacuacgucg ccgacaucga ggucgacggc aagcaggucg agcucgcccu cugggacacc      180

gccggccagg aggacuacga ccgccuccgc ccccucuccu accccgacac cgacgucauc      240

cucaugugcu ucuccaucga cucccccgac ucccucgaga acauccccga gaaguggacc      300

cccgagguca agcacuucug ccccaacguc cccaucaucc ucgucggcaa caagaaggac      360

cuccgcaacg acgagcacac ccgccgcgag cucgccaaga ugaagcagga gcccgucaag      420

cccgaggagg gccgcgacau ggccaaccgc aucggcgccu ucggcuacau ggagugcucc      480

gccaagacca aggacggcgu ccgcgagguc uucgagaugg ccacccgcgc cgcccuccag      540

gcccgccgcg gcaagaagaa guccggcugc cucguccucu ga                         582


<210>  9344
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RhoA__Homo_sapiens__AAC33178

<400>  9344
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggcaugcgg aaagaccugu       60

cuccuuauag uuuucagcaa agaucaguuu cccgaggugu acguaccuac aguguucgaa      120

aacuaugucg ccgacaucga gguggauggu aagcaaguug aacuggcguu gugggacacu      180

gcuggccagg aggauuacga cagguuacgg ccacuguccu auccggauac ggacgugauu      240

cuaaugugcu uuucuaucga uucacccgac agucucgaaa auauuccuga gaaauggacc      300

ccagagguca agcacuucug ucccaacgug ccuaucauac ugguagggaa uaagaaagau      360

cuucgcaacg acgaacauac acgacgugag cuggccaaga ugaaacagga accaguuaag      420

cccgaggagg gaagagauau ggcaaauagg aucggcgccu uugguuacau ggaaugcagc      480

gcuaaaacua aggacggggu gcgggagguc uucgaaaugg caacccgcgc cgcuuugcag      540

gccagaaggg gaaagaaaaa guccggcugu cucgugcugu ga                         582


<210>  9345
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RhoA__Homo_sapiens__AAC33178

<400>  9345
auggccgcca ucagaaagaa gcuggugauc gugggcgacg gcgccugcgg caagaccugc       60

cugcugaucg uguucagcaa ggaccaguuc cccgaggugu acgugcccac cguguucgag      120

aacuacgugg ccgacaucga gguggacggc aagcaggugg agcuggcccu gugggacacc      180

gccggccagg aggacuacga cagacugaga ccccugagcu accccgacac cgacgugauc      240

cugaugugcu ucagcaucga cagccccgac agccuggaga acauccccga gaaguggacc      300

cccgagguga agcacuucug ccccaacgug cccaucaucc uggugggcaa caagaaggac      360

cugagaaacg acgagcacac cagaagagag cuggccaaga ugaagcagga gcccgugaag      420

cccgaggagg gcagagacau ggccaacaga aucggcgccu ucggcuacau ggagugcagc      480

gccaagacca aggacggcgu gagagaggug uucgagaugg ccaccagagc cgcccugcag      540

gccagaagag gcaagaagaa gagcggcugc cuggugcugu ga                         582


<210>  9346
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RhoA__Homo_sapiens__AAC33178

<400>  9346
auggccgcua ucagaaagaa acuggugauu gucggcgacg gggccugcgg aaagaccugu       60

cuccugaucg uuuucagcaa agaucaguuu cccgaggugu acgugccuac agucuucgaa      120

aacuaugugg cggacauuga gguugauggc aagcaagugg aacuugcucu gugggacacg      180

gccgggcagg aggauuacga ccggcuccgc ccgcuguccu aucccgauac cgacgucauc      240

cuuaugugcu uuucuauuga uagcccugac ucccuggaaa auauccccga gaaauggaca      300

ccugagguga agcacuucug ucccaacguu ccuaucauuc ucgugggaaa uaagaaagau      360

cugagaaacg acgaacauac ccggcgcgag cuggccaaga ugaaacagga accggucaag      420

cccgaggagg gcagagauau ggcuaaucgg aucggggccu uuggauacau ggaaugcucu      480

gcuaaaacaa aggacggcgu gcgcgaggug uucgaaaugg ccaccagagc ggcccuccag      540

gcucggcgcg gcaagaaaaa gagcgggugu cugguccuuu ga                         582


<210>  9347
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RIG-I__Homo_sapiens__O95786

<400>  9347

Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210>  9348
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RIG-I__Homo_sapiens__AAI32787

<400>  9348
augaccaccg agcagcgacg cagccugcaa gccuuccagg auuauauccg gaagacccug       60

gacccuaccu acauccugag cuacauggcc cccugguuua gggaggaaga ggugcaguau      120

auucaggcug agaaaaacaa caagggccca auggaggcug ccacacuuuu ucucaaguuc      180

cuguuggagc uccaggagga aggcugguuc cguggcuuuu uggaugcccu agaccaugca      240

gguuauucug gacuuuauga agccauugaa aguugggauu ucaaaaaaau ugaaaaguug      300

gaggaguaua gauuacuuuu aaaacguuua caaccagaau uuaaaaccag aauuauccca      360

accgauauca uuucugaucu gucugaaugu uuaauuaauc aggaauguga agaaauucua      420

cagauuugcu cuacuaaggg gaugauggca ggugcagaga aauuggugga augccuucuc      480

agaucagaca aggaaaacug gcccaaaacu uugaaacuug cuuuggagaa agaaaggaac      540

aaguucagug aacuguggau uguagagaaa gguauaaaag auguugaaac agaagaucuu      600

gaggauaaga uggaaacuuc ugacauacag auuuucuacc aagaagaucc agaaugccag      660

aaucuuagug agaauucaug uccaccuuca gaagugucug auacaaacuu guacagccca      720

uuuaaaccaa gaaauuacca auuagagcuu gcuuugccug cuaugaaagg aaaaaacaca      780

auaauaugug cuccuacagg uuguggaaaa accuuuguuu cacugcuuau augugaacau      840

caucuuaaaa aauucccaca aggacaaaag gggaaaguug ucuuuuuugc gaaucagauc      900

ccaguguaug aacagcagaa aucuguauuc ucaaaauacu uugaaagaca uggguauaga      960

guuacaggca uuucuggagc aacagcugag aaugucccag uggaacagau uguugagaac     1020

aaugacauca ucauuuuaac uccacagauu cuugugaaca accuuaaaaa gggaacgauu     1080

ccaucacuau ccaucuuuac uuugaugaua uuugaugaau gccacaacac uaguaaacaa     1140

cacccguaca auaugaucau guuuaauuau cuagaucaga aacuuggagg aucuucaggc     1200

ccacugcccc aggucauugg gcugacugcc ucgguuggug uuggggaugc caaaaacaca     1260

gaugaagccu uggauuauau cugcaagcug ugugcuucuc uugaugcguc agugauagca     1320

acagucaaac acaaucugga ggaacuggag caaguuguuu auaagcccca gaaguuuuuc     1380

aggaaagugg aaucacggau uagcgacaaa uuuaaauaca ucauagcuca gcugaugagg     1440

gacacagaga gucuggcaaa gagaaucugc aaagaccucg aaaacuuauc ucaaauucaa     1500

aauagggaau uuggaacaca gaaauaugaa caauggauug uuacaguuca gaaagcaugc     1560

augguguucc agaugccaga caaagaugaa gagagcagga uuuguaaagc ccuguuuuua     1620

uacacuucac auuugcggaa auauaaugau gcccucauua ucagugagca ugcacgaaug     1680

aaagaugcuc uggauuacuu gaaagacuuc uucagcaaug uccgagcagc aggauucgau     1740

gagauugagc aagaucuuac ucagagauuu gaagaaaagc ugcaggaacu agaaaguguu     1800

uccagggauc ccagcaauga gaauccuaaa cuugaagacc ucugcuucau cuuacaagaa     1860

gaguaccacu uaaacccaga gacaauaaca auucucuuug ugaaaaccag agcacuugug     1920

gacgcuuuaa aaaauuggau ugaaggaaau ccuaaacuca guuuucuaaa accuggcaua     1980

uugacuggac guggcaaaac aaaucagaac acaggaauga cccucccggc acagaagugu     2040

auauuggaug cauucaaagc caguggagau cacaauauuc ugauugccac cucaguugcu     2100

gaugaaggca uugacauugc acagugcaau cuugucaucc uuuaugagua ugugggcaau     2160

gucaucaaaa ugauccaaac cagaggcaga ggaagagcaa gagguagcaa gugcuuccuu     2220

cugacuagua augcuggugu aauugaaaaa gaacaaauaa acauguacaa agaaaaaaug     2280

augaaugacu cuauuuuacg ccuucagaca ugggacgaag caguauuuag ggaaaagauu     2340

cugcauauac agacucauga aaaauucauc agagauaguc aagaaaaacc aaaaccugua     2400

ccugauaagg aaaauaaaaa acugcucugc agaaagugca aagccuuggc auguuacaca     2460

gcugacguaa gagugauaga ggaaugccau uacacugugc uuggagaugc uuuuaaggaa     2520

ugcuuuguga guagaccaca ucccaagcca aagcaguuuu caaguuuuga aaaaagagca     2580

aagauauucu gugcccgaca gaacugcagc caugacuggg gaauccaugu gaaguacaag     2640

acauuugaga uuccaguuau aaaaauugaa aguuuugugg uggaggauau ugcaacugga     2700

guucagacac uguacucgaa guggaaggac uuucauuuug agaagauacc auuugaucca     2760

gcagaaaugu ccaaauga                                                   2778


<210>  9349
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RIG-I__Homo_sapiens__AAI32787

<400>  9349
augaccaccg agcagcgccg gagccugcag gccuuccagg acuacauccg caagacgcuc       60

gaccccaccu acauccuguc cuacauggcc ccgugguucc gggaggagga ggugcaguac      120

auccaggcgg agaagaacaa caagggcccc auggaggccg ccacccuguu ccucaaguuc      180

cugcuggagc uccaggagga ggggugguuc cgcggcuucc uggacgcccu ggaccacgcc      240

ggguacagcg gccucuacga ggcgaucgag uccugggacu ucaagaagau cgagaagcug      300

gaggaguacc ggcugcuccu gaagcgccug cagcccgagu ucaagacccg gaucaucccc      360

acggacauca ucagcgaccu cuccgagugc cugaucaacc aggagugcga ggagauccug      420

cagaucugca gcaccaaggg gaugauggcc ggcgccgaga agcucgucga gugccugcug      480

cgcuccgaca aggagaacug gccgaagacc cucaagcugg cccuggagaa ggagcggaac      540

aaguucagcg agcucuggau cguggagaag ggcaucaagg acguggagac cgaggaccug      600

gaggacaaga uggagacguc cgacauccag aucuucuacc aggaggaccc cgagugccag      660

aaccugagcg agaacuccug cccgcccagc gaggucuccg acaccaaccu cuacagcccc      720

uucaagcccc gcaacuacca gcuggagcug gcgcuccccg ccaugaaggg gaagaacacc      780

aucaucugcg cccccaccgg cugcgggaag acguucgugu cccugcugau cugcgagcac      840

caccucaaga aguucccgca gggccagaag gggaaggugg ucuucuucgc caaccagauc      900

cccguguacg agcagcagaa guccguguuc agcaaguacu ucgagcggca cggcuaccgc      960

gucaccggca ucagcggggc caccgcggag aacgugcccg uggagcagau cgucgagaac     1020

aacgacauca ucauccugac gccccagauc cuggugaaca accucaagaa gggcaccauc     1080

ccgucccuga gcaucuucac ccugaugauc uucgacgagu gccacaacac cagcaagcag     1140

caccccuaca acaugaucau guucaacuac cucgaccaga agcucggggg cuccagcggc     1200

ccccugcccc aggugaucgg gcucaccgcc uccgucggcg ugggggacgc caagaacacg     1260

gacgaggccc uggacuacau cugcaagcug ugcgccagcc ucgacgcguc cgugaucgcc     1320

accgucaagc acaaccugga ggagcuggag caggucgugu acaagccgca gaaguucuuc     1380

cggaaggugg agagccgcau cuccgacaag uucaaguaca ucaucgccca gcucaugcgg     1440

gacaccgaga gccuggccaa gcgcaucugc aaggaccugg agaaccuguc ccagauccag     1500

aaccgggagu ucggcaccca gaaguacgag caguggaucg ugacggugca gaaggccugc     1560

auggucuucc agaugcccga caaggacgag gagagccgca ucugcaaggc gcuguuccug     1620

uacaccuccc accuccggaa guacaacgac gcccugauca ucagcgagca cgcccgcaug     1680

aaggacgccc uggacuaccu gaaggacuuc uucuccaacg ugcgggccgc gggguucgac     1740

gagaucgagc aggaccucac ccagcgcuuc gaggagaagc ugcaggagcu ggagagcguc     1800

ucccgcgacc ccagcaacga gaaccccaag cucgaggacc ugugcuucau ccugcaggag     1860

gaguaccacc ucaacccgga gaccaucacg auccuguucg ugaagacccg ggcccuggug     1920

gacgcccuca agaacuggau cgagggcaac cccaagcugu ccuuccugaa gcccggcauc     1980

cucaccgggc gcggcaagac caaccagaac acggggauga cccugcccgc ccagaagugc     2040

auccuggacg cguucaaggc cagcggcgac cacaacaucc ucaucgccac cuccgucgcc     2100

gacgagggga ucgacaucgc ccagugcaac cuggugaucc uguacgagua cgugggcaac     2160

gucaucaaga ugauccagac ccggggccgc gggcgggcgc gcggcagcaa gugcuuccuc     2220

cugacgagca acgccggggu gaucgagaag gagcagauca acauguacaa ggagaagaug     2280

augaacgacu ccauccugcg gcuccagacc ugggacgagg ccguguuccg cgagaagauc     2340

cugcacaucc agacccacga gaaguucauc cgggacagcc aggagaagcc gaagcccguc     2400

cccgacaagg agaacaagaa gcugcucugc cgcaagugca aggcccuggc cugcuacacc     2460

gcggacgugc gggugaucga ggagugccac uacaccgucc ugggcgacgc cuucaaggag     2520

ugcuucgugu cccgcccgca ccccaagccc aagcaguuca gcuccuucga gaagcgggcc     2580

aagaucuucu gcgcccgcca gaacugcagc cacgacuggg ggauccacgu gaaguacaag     2640

acguucgaga uccccgucau caagaucgag uccuucgugg uggaggacau cgccaccggc     2700

guccagaccc ucuacagcaa guggaaggac uuccacuucg agaagauccc guucgacccc     2760

gcggagaugu ccaaguga                                                   2778


<210>  9350
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RIG-I__Homo_sapiens__AAI32787

<400>  9350
augaccaccg agcagcgccg cucccuccag gccuuccagg acuacauccg caagacccuc       60

gaccccaccu acauccucuc cuacauggcc cccugguucc gcgaggagga gguccaguac      120

auccaggccg agaagaacaa caagggcccc auggaggccg ccacccucuu ccucaaguuc      180

cuccucgagc uccaggagga gggcugguuc cgcggcuucc ucgacgcccu cgaccacgcc      240

ggcuacuccg gccucuacga ggccaucgag uccugggacu ucaagaagau cgagaagcuc      300

gaggaguacc gccuccuccu caagcgccuc cagcccgagu ucaagacccg caucaucccc      360

accgacauca ucuccgaccu cuccgagugc cucaucaacc aggagugcga ggagauccuc      420

cagaucugcu ccaccaaggg caugauggcc ggcgccgaga agcucgucga gugccuccuc      480

cgcuccgaca aggagaacug gcccaagacc cucaagcucg cccucgagaa ggagcgcaac      540

aaguucuccg agcucuggau cgucgagaag ggcaucaagg acgucgagac cgaggaccuc      600

gaggacaaga uggagaccuc cgacauccag aucuucuacc aggaggaccc cgagugccag      660

aaccucuccg agaacuccug cccccccucc gaggucuccg acaccaaccu cuacuccccc      720

uucaagcccc gcaacuacca gcucgagcuc gcccuccccg ccaugaaggg caagaacacc      780

aucaucugcg cccccaccgg cugcggcaag accuucgucu cccuccucau cugcgagcac      840

caccucaaga aguuccccca gggccagaag ggcaaggucg ucuucuucgc caaccagauc      900

cccgucuacg agcagcagaa guccgucuuc uccaaguacu ucgagcgcca cggcuaccgc      960

gucaccggca ucuccggcgc caccgccgag aacguccccg ucgagcagau cgucgagaac     1020

aacgacauca ucauccucac cccccagauc cucgucaaca accucaagaa gggcaccauc     1080

cccucccucu ccaucuucac ccucaugauc uucgacgagu gccacaacac cuccaagcag     1140

caccccuaca acaugaucau guucaacuac cucgaccaga agcucggcgg cuccuccggc     1200

ccccuccccc aggucaucgg ccucaccgcc uccgucggcg ucggcgacgc caagaacacc     1260

gacgaggccc ucgacuacau cugcaagcuc ugcgccuccc ucgacgccuc cgucaucgcc     1320

accgucaagc acaaccucga ggagcucgag caggucgucu acaagcccca gaaguucuuc     1380

cgcaaggucg agucccgcau cuccgacaag uucaaguaca ucaucgccca gcucaugcgc     1440

gacaccgagu cccucgccaa gcgcaucugc aaggaccucg agaaccucuc ccagauccag     1500

aaccgcgagu ucggcaccca gaaguacgag caguggaucg ucaccgucca gaaggccugc     1560

auggucuucc agaugcccga caaggacgag gagucccgca ucugcaaggc ccucuuccuc     1620

uacaccuccc accuccgcaa guacaacgac gcccucauca ucuccgagca cgcccgcaug     1680

aaggacgccc ucgacuaccu caaggacuuc uucuccaacg uccgcgccgc cggcuucgac     1740

gagaucgagc aggaccucac ccagcgcuuc gaggagaagc uccaggagcu cgaguccguc     1800

ucccgcgacc ccuccaacga gaaccccaag cucgaggacc ucugcuucau ccuccaggag     1860

gaguaccacc ucaaccccga gaccaucacc auccucuucg ucaagacccg cgcccucguc     1920

gacgcccuca agaacuggau cgagggcaac cccaagcucu ccuuccucaa gcccggcauc     1980

cucaccggcc gcggcaagac caaccagaac accggcauga cccuccccgc ccagaagugc     2040

auccucgacg ccuucaaggc cuccggcgac cacaacaucc ucaucgccac cuccgucgcc     2100

gacgagggca ucgacaucgc ccagugcaac cucgucaucc ucuacgagua cgucggcaac     2160

gucaucaaga ugauccagac ccgcggccgc ggccgcgccc gcggcuccaa gugcuuccuc     2220

cucaccucca acgccggcgu caucgagaag gagcagauca acauguacaa ggagaagaug     2280

augaacgacu ccauccuccg ccuccagacc ugggacgagg ccgucuuccg cgagaagauc     2340

cuccacaucc agacccacga gaaguucauc cgcgacuccc aggagaagcc caagcccguc     2400

cccgacaagg agaacaagaa gcuccucugc cgcaagugca aggcccucgc cugcuacacc     2460

gccgacgucc gcgucaucga ggagugccac uacaccgucc ucggcgacgc cuucaaggag     2520

ugcuucgucu cccgccccca ccccaagccc aagcaguucu ccuccuucga gaagcgcgcc     2580

aagaucuucu gcgcccgcca gaacugcucc cacgacuggg gcauccacgu caaguacaag     2640

accuucgaga uccccgucau caagaucgag uccuucgucg ucgaggacau cgccaccggc     2700

guccagaccc ucuacuccaa guggaaggac uuccacuucg agaagauccc cuucgacccc     2760

gccgagaugu ccaaguga                                                   2778


<210>  9351
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RIG-I__Homo_sapiens__AAI32787

<400>  9351
augaccacag agcagagaag gagccugcaa gccuuccagg acuacauccg gaagacucuc       60

gaucccacgu auauucuuuc cuacauggcu ccuugguuuc gcgaagagga agugcaguau      120

auacaggcag agaaaaacaa uaagggccca auggaagccg cgacccuguu cuugaaauuu      180

uuacuggagc uacaagagga agggugguuc cgaggauuuc ucgacgcucu ggaucacgcc      240

gguuacucug gccuuuauga ggcaaucgaa ucaugggacu ucaagaaaau ugagaagcug      300

gaggaauacc guuugcuccu gaagagacug cagccggagu uuaaaacaag gaucauuccc      360

acugauauca uaagugaccu cagcgaaugc uuaaucaacc aggaguguga agagauucug      420

cagaucugcu ccaccaaggg gaugauggcc ggagcugaga aacuugucga auguuugcug      480

cggucugaua aggagaauug gccuaaaaca cuaaagcucg cacuggaaaa ggagcgcaac      540

aaauucucgg aacuuuggau uguugagaag ggcaucaaag acguggagac cgaagaucug      600

gaggacaaga uggaaacuuc agauauacaa aucuuuuauc aggaggaccc agaaugccag      660

aauuugagcg agaacaguug ucccccuucc gagguaucug auacaaaucu cuacagccca      720

uucaaaccca gaaacuacca gcuggaauua gcccugccug cuaugaaggg uaaaaauacc      780

auuauuugcg ccccaacggg guguggaaag acuuuugugu cccuccuuau cugcgagcau      840

caccugaaga aauucccgca aggccagaag ggcaaagucg uguuuuucgc gaaccagauc      900

cccguuuaug aacaacagaa gucaguguuc aguaaauacu uugagaggca uggguaucgg      960

gucaccggaa uuagcggugc aacagccgag aaugugccug uagaacagau aguugagaac     1020

aaugacauca uuaucuugac uccacagaua cuggugaaca aucugaagaa gggcaccauu     1080

cccucucucu ccaucuucac acugaugauc uuugacgaau gucacaacac cucaaaacaa     1140

cauccuuaca acaugauuau guucaauuau cuugaucaga agcuaggggg aagcaguggc     1200

ccauugcccc aggucaucgg ucucacggcu ucuguggggg ugggagacgc caaaaacacu     1260

gaugaggcac uggacuacau uugcaaguua ugugcuuccc uggaugccag cgucauagcg     1320

acaguuaaac acaaucuaga ggagcucgaa caggugguau auaagccgca aaaguuuuuc     1380

cgcaaagugg aaucgcgaau cucugacaag uuuaaauaca uuaucgccca gcugaugaga     1440

gauaccgagu cccuugcaaa gaggaucugc aaagacuugg aaaaccuguc acagauucag     1500

aaucgggagu ucggcacuca aaaguacgaa caguggauag ucacagugca gaaggcuugc     1560

augguuuuuc agaugccuga uaaagacgag gagagucgua ucuguaaggc ccucuuccug     1620

uauaccagcc accuucgcaa auacaacgau gcucugauua ucuccgaaca ugccagaaug     1680

aaggacgcau uggacuaucu caaagacuuu uucucuaaug ugagggccgc uggcuuugau     1740

gagauugaac aagaucugac gcagcgguuc gaggaaaagu uacaggagcu ggagagcguc     1800

ucacgagacc ccaguaacga aaauccaaaa cuagaggauc ucugcuucau ccugcaagaa     1860

gaguaccacc uuaacccuga gaccauaaca aucuuguuug ugaagacucg cgcgcuggua     1920

gacgcacuca agaauuggau ugaagggaac cccaaacugu ccuucuuaaa gccaggaauc     1980

cugaccggua gaggcaaaac aaaucagaac acugggauga cccuucccgc ccagaagugu     2040

auuuuggaug cuuuuaaagc cagcggagac cauaauaucc ucauagcaac aucuguugcc     2100

gaugagggca uugacaucgc ucagugcaac cuggugauuc uauaugaaua cgucgguaac     2160

gugaucaaga ugauacaaac cagggggcgg ggccgcgcca gaggaucaaa guguuuccug     2220

cucacgagua augcaggcgu caucgagaaa gaacagauua acauguauaa ggagaaaaug     2280

augaaugaua gcauccugag gcuucagacu ugggacgagg cgguguuucg ugaaaagauu     2340

uugcacaucc agacacacga gaaauucaua cgggauuccc aagaaaagcc uaagccaguu     2400

ccggacaaag agaacaagaa acuguuaugc cgaaagugua aagcucucgc cugcuacacc     2460

gcagacguga gaguaauuga agagugucau uacacugucc ugggggaugc cuuuaaggag     2520

ugcuucgugu cuaggcccca cccuaagcca aaacaguuuu cgagcuucga aaagcgcgcu     2580

aaaaucuuuu gugcccggca gaauugcucc caugacuggg gaauccacgu uaaguauaaa     2640

accuucgaga uucccgugau caagauugaa ucauuugucg uggaggauau agcaacaggu     2700

guacagaccc uuuacaguaa auggaaggac uuccauuucg aaaagauccc uuuugaucca     2760

gcugagaugu cuaaauga                                                   2778


<210>  9352
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RIG-I__Homo_sapiens__AAI32787

<400>  9352
augaccaccg agcagagaag aagccugcag gccuuccagg acuacaucag aaagacccug       60

gaccccaccu acauccugag cuacauggcc cccugguuca gagaggagga ggugcaguac      120

auccaggccg agaagaacaa caagggcccc auggaggccg ccacccuguu ccugaaguuc      180

cugcuggagc ugcaggagga gggcugguuc agaggcuucc uggacgcccu ggaccacgcc      240

ggcuacagcg gccuguacga ggccaucgag agcugggacu ucaagaagau cgagaagcug      300

gaggaguaca gacugcugcu gaagagacug cagcccgagu ucaagaccag aaucaucccc      360

accgacauca ucagcgaccu gagcgagugc cugaucaacc aggagugcga ggagauccug      420

cagaucugca gcaccaaggg caugauggcc ggcgccgaga agcuggugga gugccugcug      480

agaagcgaca aggagaacug gcccaagacc cugaagcugg cccuggagaa ggagagaaac      540

aaguucagcg agcuguggau cguggagaag ggcaucaagg acguggagac cgaggaccug      600

gaggacaaga uggagaccag cgacauccag aucuucuacc aggaggaccc cgagugccag      660

aaccugagcg agaacagcug cccccccagc gaggugagcg acaccaaccu guacagcccc      720

uucaagccca gaaacuacca gcuggagcug gcccugcccg ccaugaaggg caagaacacc      780

aucaucugcg cccccaccgg cugcggcaag accuucguga gccugcugau cugcgagcac      840

caccugaaga aguuccccca gggccagaag ggcaaggugg uguucuucgc caaccagauc      900

cccguguacg agcagcagaa gagcguguuc agcaaguacu ucgagagaca cggcuacaga      960

gugaccggca ucagcggcgc caccgccgag aacgugcccg uggagcagau cguggagaac     1020

aacgacauca ucauccugac cccccagauc cuggugaaca accugaagaa gggcaccauc     1080

cccagccuga gcaucuucac ccugaugauc uucgacgagu gccacaacac cagcaagcag     1140

caccccuaca acaugaucau guucaacuac cuggaccaga agcugggcgg cagcagcggc     1200

ccccugcccc aggugaucgg ccugaccgcc agcgugggcg ugggcgacgc caagaacacc     1260

gacgaggccc uggacuacau cugcaagcug ugcgccagcc uggacgccag cgugaucgcc     1320

accgugaagc acaaccugga ggagcuggag cagguggugu acaagcccca gaaguucuuc     1380

agaaaggugg agagcagaau cagcgacaag uucaaguaca ucaucgccca gcugaugaga     1440

gacaccgaga gccuggccaa gagaaucugc aaggaccugg agaaccugag ccagauccag     1500

aacagagagu ucggcaccca gaaguacgag caguggaucg ugaccgugca gaaggccugc     1560

augguguucc agaugcccga caaggacgag gagagcagaa ucugcaaggc ccuguuccug     1620

uacaccagcc accugagaaa guacaacgac gcccugauca ucagcgagca cgccagaaug     1680

aaggacgccc uggacuaccu gaaggacuuc uucagcaacg ugagagccgc cggcuucgac     1740

gagaucgagc aggaccugac ccagagauuc gaggagaagc ugcaggagcu ggagagcgug     1800

agcagagacc ccagcaacga gaaccccaag cuggaggacc ugugcuucau ccugcaggag     1860

gaguaccacc ugaaccccga gaccaucacc auccuguucg ugaagaccag agcccuggug     1920

gacgcccuga agaacuggau cgagggcaac cccaagcuga gcuuccugaa gcccggcauc     1980

cugaccggca gaggcaagac caaccagaac accggcauga cccugcccgc ccagaagugc     2040

auccuggacg ccuucaaggc cagcggcgac cacaacaucc ugaucgccac cagcguggcc     2100

gacgagggca ucgacaucgc ccagugcaac cuggugaucc uguacgagua cgugggcaac     2160

gugaucaaga ugauccagac cagaggcaga ggcagagcca gaggcagcaa gugcuuccug     2220

cugaccagca acgccggcgu gaucgagaag gagcagauca acauguacaa ggagaagaug     2280

augaacgaca gcauccugag acugcagacc ugggacgagg ccguguucag agagaagauc     2340

cugcacaucc agacccacga gaaguucauc agagacagcc aggagaagcc caagcccgug     2400

cccgacaagg agaacaagaa gcugcugugc agaaagugca aggcccuggc cugcuacacc     2460

gccgacguga gagugaucga ggagugccac uacaccgugc ugggcgacgc cuucaaggag     2520

ugcuucguga gcagacccca ccccaagccc aagcaguuca gcagcuucga gaagagagcc     2580

aagaucuucu gcgccagaca gaacugcagc cacgacuggg gcauccacgu gaaguacaag     2640

accuucgaga uccccgugau caagaucgag agcuucgugg uggaggacau cgccaccggc     2700

gugcagaccc uguacagcaa guggaaggac uuccacuucg agaagauccc cuucgacccc     2760

gccgagauga gcaaguga                                                   2778


<210>  9353
<211>  2778
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RIG-I__Homo_sapiens__AAI32787

<400>  9353
augaccacag agcagagacg gagccugcaa gccuuccagg acuacauccg caagacgcuc       60

gaucccaccu auauucuguc cuacauggcu ccuugguuua gagaagagga agugcaguau      120

auccaggccg agaaaaacaa uaagggcccg auggaagcgg cuacacuuuu ccugaaauuu      180

cuccuggagc uucaagagga agggugguuc cggggauuuc uggacgcccu cgaucacgcc      240

ggcuacucug ggcuguauga ggcuauugaa agcugggacu ucaagaaaau cgagaagcug      300

gaggaauacc gccuccugcu uaagagacug cagcccgagu uuaaaacccg gauuaucccu      360

acagauauca uuuccgaccu cucugaaugc cugaucaacc aggaguguga agagauucuu      420

cagaucugca gcaccaaggg aaugauggcc ggcgcugaga aacuggucga augucuccug      480

cgcuccgaua aggagaauug gcccaaaaca cugaagcucg cccuggaaaa ggagagaaac      540

aaauucucug aacuuuggau uguugagaag gggaucaaag acguggagac cgaagaucug      600

gaggacaaga uggaaacgag cgauauucaa aucuuuuauc aggaggaccc ugaaugccag      660

aaucucuccg agaacagcug ucccccuucu gagguguccg auaccaaucu guacagcccg      720

uucaaacccc ggaacuacca gcuugaacug gcgcucccug ccaugaaggg gaaaaauaca      780

aucauuugcg cucccaccgg cuguggcaag acauuugucu cucugcugau cugcgagcau      840

caccucaaga aauucccuca agggcagaag ggaaaagugg uguuuuucgc caaccagauu      900

cccguuuaug aacaacagaa guccgucuuc agcaaauacu uugagcgcca uggcuauaga      960

gugaccggga ucucuggagc uacggccgag aauguuccgg uggaacagau ugucgagaac     1020

aaugacauca ucauucugac accucagauc cuugugaaca aucugaagaa gggcaccauu     1080

cccucccuca gcaucuucac acugaugauu uuugacgaau gucacaacac cuccaaacaa     1140

cauccuuaca acaugaucau guucaauuau cuugaucaga agcugggagg aucuagcggc     1200

ccccuccccc aggugaucgg ccugaccgcg uccgucgggg uuggagacgc caaaaacaca     1260

gaugaggcuc uggacuacau uugcaagcuc ugugccagcc uggaugcuuc ugugaucgcc     1320

acggugaaac acaaucuuga ggaacuggag caggucgugu auaagccuca aaaguuuuuc     1380

cggaaaguug aaucccgcau uagcgacaag uuuaaauaca ucauugccca gcucaugaga     1440

gauaccgagu cucuggcuaa gcggaucugc aaagaccugg aaaaccuuag ccagauucag     1500

aaucgcgagu ucggcacaca aaaguacgaa caguggaucg ugaccgucca gaaggcgugc     1560

augguguuuc agaugccgga uaaagacgag gaguccagaa ucuguaaggc ccucuuccug     1620

uauacaucuc aucugcggaa auacaacgau gcucucauua ucagcgaaca cgccagaaug     1680

aaggacgccc uggacuaucu uaaagacuuu uucuccaaug uucgcgcugc cggguuugau     1740

gagauugaac aagaucugac ccagcgguuc gaggaaaagc uccaggagcu ggagagcgug     1800

ucuagagacc ccuccaacga aaauccuaaa cuggaggauc uuugcuucau ccuccaagaa     1860

gaguaccacc ugaaccccga gacgauuaca auccuguuug ucaagacccg cgcgcucgug     1920

gacgcucuga agaauuggau cgaaggaaac ccuaaacuua gcuuccugaa gcccggcauu     1980

cucaccgggc ggggaaaaac aaaucagaac accggcauga cacugccggc ccagaagugu     2040

auccuggaug ccuuuaaggc uucuggcgac cauaauauuc uuaucgccac guccgucgcu     2100

gaugagggga uugacaucgc ccagugcaac cucgugaucc uguaugaaua cguuggaaac     2160

gugauuaaaa ugauccaaac cagaggccgc gggcgggcga gaggaagcaa guguuuccug     2220

cucacaucca augccggcgu cauugagaaa gaacagauca acauguauaa ggagaaaaug     2280

augaaugauu cuauucugcg ccuucagacc ugggacgagg cuguguuucg ggaaaagauc     2340

cugcacaucc agacacacga gaaauucauu agagauagcc aagaaaagcc uaagcccguu     2400

ccugacaaag agaacaagaa acuccugugc cgcaagugua aagcccuggc uugcuacacc     2460

gccgacgugc gggucaucga agagugucau uacacggugc uuggggaugc guuuaaggag     2520

ugcuucgugu ccagacccca cccuaagccc aaacaguuuu cuagcuucga aaagcgggcc     2580

aaaaucuuuu gugcucgcca gaauugcucc caugacuggg gcauucacgu uaaguauaaa     2640

accuucgaga uuccggucau caagauugag agcuuugugg uggaagauau cgccacagga     2700

guccagaccc ucuacucuaa auggaaggac uuccauuucg aaaagauccc uuuugauccc     2760

gcugagaugu ccaaauga                                                   2778


<210>  9354
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  RIG-I__Homo_sapiens__Q8IUD6

<400>  9354

Met Ala Gly Leu Gly Leu Gly Ser Ala Val Pro Val Trp Leu Ala Glu 
1               5                   10                  15      


Asp Asp Leu Gly Cys Ile Ile Cys Gln Gly Leu Leu Asp Trp Pro Ala 
            20                  25                  30          


Thr Leu Pro Cys Gly His Ser Phe Cys Arg His Cys Leu Glu Ala Leu 
        35                  40                  45              


Trp Gly Ala Arg Asp Ala Arg Arg Trp Ala Cys Pro Thr Cys Arg Gln 
    50                  55                  60                  


Gly Ala Ala Gln Gln Pro His Leu Arg Lys Asn Thr Leu Leu Gln Asp 
65                  70                  75                  80  


Leu Ala Asp Lys Tyr Arg Arg Ala Ala Arg Glu Ile Gln Ala Gly Ser 
                85                  90                  95      


Asp Pro Ala His Cys Pro Cys Pro Gly Ser Ser Ser Leu Ser Ser Ala 
            100                 105                 110         


Ala Ala Arg Pro Arg Arg Arg Pro Glu Leu Gln Arg Val Ala Val Glu 
        115                 120                 125             


Lys Ser Ile Thr Glu Val Ala Gln Glu Leu Thr Glu Leu Val Glu His 
    130                 135                 140                 


Leu Val Asp Ile Val Arg Ser Leu Gln Asn Gln Arg Pro Leu Ser Glu 
145                 150                 155                 160 


Ser Gly Pro Asp Asn Glu Leu Ser Ile Leu Gly Lys Ala Phe Ser Ser 
                165                 170                 175     


Gly Val Asp Leu Ser Met Ala Ser Pro Lys Leu Val Thr Ser Asp Thr 
            180                 185                 190         


Ala Ala Gly Lys Ile Arg Asp Ile Leu His Asp Leu Glu Glu Ile Gln 
        195                 200                 205             


Glu Lys Leu Gln Glu Ser Val Thr Trp Lys Glu Ala Pro Glu Ala Gln 
    210                 215                 220                 


Met Gln Gly Glu Leu Leu Glu Ala Pro Ser Ser Ser Ser Cys Pro Leu 
225                 230                 235                 240 


Pro Asp Gln Ser His Pro Ala Leu Arg Arg Ala Ser Arg Phe Ala Gln 
                245                 250                 255     


Trp Ala Ile His Pro Thr Phe Asn Leu Lys Ser Leu Ser Cys Ser Leu 
            260                 265                 270         


Glu Val Ser Lys Asp Ser Arg Thr Val Thr Val Ser His Arg Pro Gln 
        275                 280                 285             


Pro Tyr Arg Trp Ser Cys Glu Arg Phe Ser Thr Ser Gln Val Leu Cys 
    290                 295                 300                 


Ser Gln Ala Leu Ser Ser Gly Lys His Tyr Trp Glu Val Asp Thr Arg 
305                 310                 315                 320 


Asn Cys Ser His Trp Ala Val Gly Val Ala Ser Trp Glu Met Ser Arg 
                325                 330                 335     


Asp Gln Val Leu Gly Arg Thr Met Asp Ser Cys Cys Val Glu Trp Lys 
            340                 345                 350         


Gly Thr Ser Gln Leu Ser Ala Trp His Met Val Lys Glu Thr Val Leu 
        355                 360                 365             


Gly Ser Asp Arg Pro Gly Val Val Gly Ile Trp Leu Asn Leu Glu Glu 
    370                 375                 380                 


Gly Lys Leu Ala Phe Tyr Ser Val Asp Asn Gln Glu Lys Leu Leu Tyr 
385                 390                 395                 400 


Glu Cys Thr Ile Ser Ala Ser Ser Pro Leu Tyr Pro Ala Phe Trp Leu 
                405                 410                 415     


Tyr Gly Leu His Pro Gly Asn Tyr Leu Ile Ile Lys Gln Val Lys Val 
            420                 425                 430         






<210>  9355
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  RIG-I__Homo_sapiens__AAI26421

<400>  9355
auggcgggcc ugggccuggg cuccgccguu cccguguggc uggccgagga cgaccucggc       60

ugcaucaucu gccaggggcu gcuggacugg cccgccacgc ugcccugcgg ccacagcuuc      120

ugccgccacu gccuggaggc ccuguggggc gcccgcgacg cccgccgcug ggccugcccc      180

acuugccgcc agggcgccgc gcagcagccg caccugcgga agaacacgcu acugcaggac      240

cuggccgaca aguaccgccg cgccgcacgc gagauacagg cgggcuccga cccugcccac      300

ugccccugcc cgggcuccag uucccucucc agcgcggccg cgaggccccg gcgccgcccg      360

gaacugcagc ggguggcagu agagaagagc aucacagaag uugcucagga gcugacagag      420

cugguggaac aucuuguaga cauugucaga agccugcaga aucagaggcc ccuaucagaa      480

ucuggaccag acaacgaacu gagcauccug ggcaaggcuu uuucuucugg gguggaucuu      540

uccauggcuu cuccaaagcu ggugacuucc gacacagcug cagggaaaau cagagauauu      600

cuccaugacc uagaagaaau ucaggaaaaa uuacaagaaa gcgucaccug gaaagaggcu      660

ccugaagcac aaaugcaggg agaacuccug gaagccccgu cuuccuccuc augcccauug      720

ccugaccaga gccacccugc acucaggaga gcuucucggu uugcucagug ggccauccau      780

ccaaccuuua acuugaagag ccuuuccugc agccuggagg uguccaagga uucccguaca      840

gugacugugu cucaccgccc acaacccuau cgcuggagcu gugagagguu uucuaccagc      900

caggucuuau guucccaggc ccugucuucu ggaaagcauu acugggaagu ggacacuagg      960

aauugcagcc acugggcagu ugggguggcu uccugggaga ugagccgcga ccagguccug     1020

ggaaggacua uggacucuug uuguguggaa uggaagggga cuagccagcu cucugcaugg     1080

cacaugguca aggaaacugu ccuuggcuca gacagaccug gggugguggg caucuggcug     1140

aaccuugagg agggaaagcu ugccuucuau ucaguggaca aucaggagaa gcuucuguau     1200

gaguguacca ucucugccuc cucuccuuug uacccugccu ucuggcugua uggcuuacau     1260

ccuggaaauu accugauaau aaagcaagua aagguguaa                            1299


<210>  9356
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       RIG-I__Homo_sapiens__AAI26421

<400>  9356
auggccggcc uggggcucgg cagcgccgug cccgucuggc uggcggagga cgaccugggg       60

ugcaucaucu gccagggccu ccuggacugg ccggccaccc ugcccugcgg gcacuccuuc      120

ugccgccacu gccucgaggc ccuguggggc gcccgggacg cccgccggug ggcgugcccg      180

accugccgcc agggcgccgc ccagcagccc caccuccgga agaacacgcu gcugcaggac      240

cuggccgaca aguaccgccg ggcggcccgc gagauccagg ccgggagcga ccccgcccac      300

ugccccugcc ccggcuccag cucccucagc uccgccgcgg cccggccccg ccggcgcccg      360

gagcugcagc ggguggccgu ggagaagucc aucaccgagg ucgcccagga gcugaccgag      420

cucguggagc accuggugga caucguccgc ucccugcaga accagcggcc ccucagcgag      480

uccgggcccg acaacgagcu gagcauccug ggcaaggccu ucuccagcgg gguggaccuc      540

uccauggcga gccccaagcu ggugaccucc gacacggccg ccggcaagau ccgcgacauc      600

cugcacgacc ucgaggagau ccaggagaag cugcaggaga gcgucaccug gaaggaggcc      660

ccggaggccc agaugcaggg cgagcugcuc gaggcgcccu ccagcagcuc cugcccccug      720

cccgaccaga gccacccggc ccugcggcgc gccucccggu ucgcccagug ggccauccac      780

cccaccuuca accucaagag ccuguccugc agccuggagg uguccaagga cagccgcacc      840

gugacggucu cccaccggcc ccagcccuac cgcuggagcu gcgagcgcuu cuccaccagc      900

caggugcucu gcucccaggc gcugagcucc gggaagcacu acugggaggu ggacacccgg      960

aacugcagcc acugggccgu cggcguggcc uccugggaga ugagccgcga ccaggugcug     1020

gggcggacca uggacuccug cugcgucgag uggaagggca cgagccagcu cagcgccugg     1080

cacaugguga aggagaccgu gcugggcucc gaccgcccgg gggucguggg caucuggcug     1140

aaccucgagg aggggaagcu ggcguucuac agcguggaca accaggagaa gcugcucuac     1200

gagugcacca ucuccgccag cagcccccug uaccccgccu ucuggcugua cggccuccac     1260

cccgggaacu accugaucau caagcagguc aagguguga                            1299


<210>  9357
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       RIG-I__Homo_sapiens__AAI26421

<400>  9357
auggccggcc ucggccucgg cuccgccguc cccgucuggc ucgccgagga cgaccucggc       60

ugcaucaucu gccagggccu ccucgacugg cccgccaccc uccccugcgg ccacuccuuc      120

ugccgccacu gccucgaggc ccucuggggc gcccgcgacg cccgccgcug ggccugcccc      180

accugccgcc agggcgccgc ccagcagccc caccuccgca agaacacccu ccuccaggac      240

cucgccgaca aguaccgccg cgccgcccgc gagauccagg ccggcuccga ccccgcccac      300

ugccccugcc ccggcuccuc cucccucucc uccgccgccg cccgcccccg ccgccgcccc      360

gagcuccagc gcgucgccgu cgagaagucc aucaccgagg ucgcccagga gcucaccgag      420

cucgucgagc accucgucga caucguccgc ucccuccaga accagcgccc ccucuccgag      480

uccggccccg acaacgagcu cuccauccuc ggcaaggccu ucuccuccgg cgucgaccuc      540

uccauggccu cccccaagcu cgucaccucc gacaccgccg ccggcaagau ccgcgacauc      600

cuccacgacc ucgaggagau ccaggagaag cuccaggagu ccgucaccug gaaggaggcc      660

cccgaggccc agaugcaggg cgagcuccuc gaggcccccu ccuccuccuc cugcccccuc      720

cccgaccagu cccaccccgc ccuccgccgc gccucccgcu ucgcccagug ggccauccac      780

cccaccuuca accucaaguc ccucuccugc ucccucgagg ucuccaagga cucccgcacc      840

gucaccgucu cccaccgccc ccagcccuac cgcugguccu gcgagcgcuu cuccaccucc      900

cagguccucu gcucccaggc ccucuccucc ggcaagcacu acugggaggu cgacacccgc      960

aacugcuccc acugggccgu cggcgucgcc uccugggaga ugucccgcga ccagguccuc     1020

ggccgcacca uggacuccug cugcgucgag uggaagggca ccucccagcu cuccgccugg     1080

cacaugguca aggagaccgu ccucggcucc gaccgccccg gcgucgucgg caucuggcuc     1140

aaccucgagg agggcaagcu cgccuucuac uccgucgaca accaggagaa gcuccucuac     1200

gagugcacca ucuccgccuc cuccccccuc uaccccgccu ucuggcucua cggccuccac     1260

cccggcaacu accucaucau caagcagguc aaggucuga                            1299


<210>  9358
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       RIG-I__Homo_sapiens__AAI26421

<400>  9358
auggccggcc uggggcucgg aagcgcugug cccgucuggc uugcagagga cgaucugggu       60

ugcaucauuu gucagggcuu guuagacugg ccugccaccc ugccaugcgg gcacuccuuc      120

uguagacauu gccuagaagc gcucugggga gcuagggaug cccggcgcug ggcauguccg      180

acaugccgac aaggcgccgc ucagcagccc caucugcgua agaacacucu ucugcaggac      240

uuggcagaua aauacagaag ggccgcucgg gagauacaag ccgguucuga cccugcgcac      300

uguccaugcc ccgggucaag uagccucucc ucugcagccg cucgcccuag aaggcggcca      360

gaacugcagc gcguugccgu ggagaagucg aucacggaag uagcacagga gcugaccgag      420

cucguggaac acuuagucga uauugugcga ucacugcaga aucaaagacc ccuuagcgag      480

aguggaccug acaacgaauu guccauccug ggcaaggcuu uuucuagcgg cguugaucua      540

uccauggccu caccaaaacu cgugacaagu gacacugcgg ccgggaaaau uagggauauc      600

cugcaugacc uugaggagau acaggaaaag cugcaggaga gcgucaccug gaaggaagca      660

ccggaggcuc agaugcaagg agaauugcuc gaggcccccu cuuccucaag cuguccucug      720

ccagaucaga gucaccccgc uuuacggcgu gccucucgcu ucgcacagug ggccauccac      780

ccuacauuua aucugaaauc ccucagcugc ucgcuugagg ugucuaagga cuccagaacc      840

guaacuguuu cacauaggcc acaacccuau cgguggaguu gugaacgauu cagcacaucc      900

caggugcugu gcucucaggc uuugagcuca gguaaacacu acugggaggu cgacacccgc      960

aacugcaguc auugggcggu gggcguggca uccugggaaa ugagcagaga ucagguccua     1020

gggaggacga uggacucuug uugcguugag uggaagggaa cuucacaacu gagugccugg     1080

cacaugguga aagaaaccgu acucggcagc gaucggccgg guguggucgg gauuuggcug     1140

aaucuugagg agggaaagcu ggcuuuuuau uccguggaca accaggaaaa guugcucuac     1200

gaguguacaa ucucugccuc gagcccucug uaucccgcau ucugguuaua cggccugcac     1260

ccaggcaauu aucuaauuau caaacagguu aagguguga                            1299


<210>  9359
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       RIG-I__Homo_sapiens__AAI26421

<400>  9359
auggccggcc ugggccuggg cagcgccgug cccguguggc uggccgagga cgaccugggc       60

ugcaucaucu gccagggccu gcuggacugg cccgccaccc ugcccugcgg ccacagcuuc      120

ugcagacacu gccuggaggc ccuguggggc gccagagacg ccagaagaug ggccugcccc      180

accugcagac agggcgccgc ccagcagccc caccugagaa agaacacccu gcugcaggac      240

cuggccgaca aguacagaag agccgccaga gagauccagg ccggcagcga ccccgcccac      300

ugccccugcc ccggcagcag cagccugagc agcgccgccg ccagacccag aagaagaccc      360

gagcugcaga gaguggccgu ggagaagagc aucaccgagg uggcccagga gcugaccgag      420

cugguggagc accuggugga caucgugaga agccugcaga accagagacc ccugagcgag      480

agcggccccg acaacgagcu gagcauccug ggcaaggccu ucagcagcgg cguggaccug      540

agcauggcca gccccaagcu ggugaccagc gacaccgccg ccggcaagau cagagacauc      600

cugcacgacc uggaggagau ccaggagaag cugcaggaga gcgugaccug gaaggaggcc      660

cccgaggccc agaugcaggg cgagcugcug gaggccccca gcagcagcag cugcccccug      720

cccgaccaga gccaccccgc ccugagaaga gccagcagau ucgcccagug ggccauccac      780

cccaccuuca accugaagag ccugagcugc agccuggagg ugagcaagga cagcagaacc      840

gugaccguga gccacagacc ccagcccuac agauggagcu gcgagagauu cagcaccagc      900

caggugcugu gcagccaggc ccugagcagc ggcaagcacu acugggaggu ggacaccaga      960

aacugcagcc acugggccgu gggcguggcc agcugggaga ugagcagaga ccaggugcug     1020

ggcagaacca uggacagcug cugcguggag uggaagggca ccagccagcu gagcgccugg     1080

cacaugguga aggagaccgu gcugggcagc gacagacccg gcgugguggg caucuggcug     1140

aaccuggagg agggcaagcu ggccuucuac agcguggaca accaggagaa gcugcuguac     1200

gagugcacca ucagcgccag cagcccccug uaccccgccu ucuggcugua cggccugcac     1260

cccggcaacu accugaucau caagcaggug aagguguga                            1299


<210>  9360
<211>  1299
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       RIG-I__Homo_sapiens__AAI26421

<400>  9360
auggccggcc uggggcucgg aagcgcugug cccgucuggc uggccgagga cgaucuuggc       60

ugcaucauuu gucaggggcu gcucgacugg ccugcgaccc ugccgugcgg acacuccuuc      120

uguagacauu gccuugaagc ucuguggggc gcccgggaug cccgcagaug ggcuuguccc      180

acaugccggc aaggggccgc ucagcagccu caccuccgca agaacacgcu gcugcaggac      240

cucgccgaua aauacagacg ggcggcccgc gagauccaag cuggaucuga ccccgcccau      300

uguccuugcc ccggcagcuc cucucugagc uccgcugccg cgagaccucg gcgcagaccg      360

gaacuucagc ggguugccgu ggagaagucu auuaccgaag uggcucagga gcugacagag      420

cucgucgaac accuggugga uaucguucgc agccuucaga aucaaagacc ccuguccgag      480

agcggcccug acaacgaacu cucuauucug gggaaagccu uuuccagcgg aguggaucug      540

ucuauggcuu cccccaagcu cgucaccagc gacacagccg ccggcaaaau ccgggauauc      600

cugcaugacc uugaggagau ucaggaaaag cugcaggagu cugugaccug gaaggaagcu      660

ccugaggcgc agaugcaagg ggaacuccug gaggcccccu ccagcuccuc uuguccgcuu      720

ccugaucaga gccaccccgc ucugcgcaga gccucccggu ucgcccagug ggcuauccac      780

ccuacauuua aucucaaaag ccugucuugc ucccuggagg uuagcaagga cucuagaacc      840

gugacgguca gccaucgccc ccaacccuau cggugguccu gugaaagauu cucuaccagc      900

caggugcucu gcucccaggc ccugagcucu ggaaaacacu acugggaggu ggacacacgc      960

aacugcuccc auugggcggu cggcguugcu agcugggaaa ugucucggga ucaggugcuu     1020

gggagaacca uggacuccug uugcguggag uggaagggaa caagccaacu guccgccugg     1080

cacaugguca aagaaaccgu gcucggcucu gaucgcccug gcguuguggg gauuuggcug     1140

aaucuugagg agggaaagcu ggccuuuuau agcgucgaca accaggaaaa gcuccuguac     1200

gaguguacga ucuccgcuuc uagcccgcug uaucccgccu ucuggcucua cggccugcac     1260

ccugggaauu aucuuauuau caaacaggug aagguuuga                            1299


<210>  9361
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Src-Kinases__Homo_sapiens__Q9H5V8

<400>  9361

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Asn Lys Ile Tyr Val Val Asp Leu Ser Asn Glu 
            340                 345                 350         


Arg Ala Met Ser Leu Thr Ile Glu Pro Arg Pro Val Lys Gln Ser Arg 
        355                 360                 365             


Lys Phe Val Pro Gly Cys Phe Val Cys Leu Glu Ser Arg Thr Cys Ser 
    370                 375                 380                 


Ser Asn Leu Thr Leu Thr Ser Gly Ser Lys His Lys Ile Ser Phe Leu 
385                 390                 395                 400 


Cys Asp Asp Leu Thr Arg Leu Trp Met Asn Val Glu Lys Thr Ile Ser 
                405                 410                 415     


Cys Thr Asp His Arg Tyr Cys Gln Arg Lys Ser Tyr Ser Leu Gln Val 
            420                 425                 430         


Pro Ser Asp Ile Leu His Leu Pro Val Glu Leu His Asp Phe Ser Trp 
        435                 440                 445             


Lys Leu Leu Val Pro Lys Asp Arg Leu Ser Leu Val Leu Val Pro Ala 
    450                 455                 460                 


Gln Lys Leu Gln Gln His Thr His Glu Lys Pro Cys Asn Thr Ser Phe 
465                 470                 475                 480 


Ser Tyr Leu Val Ala Ser Ala Ile Pro Ser Gln Asp Leu Tyr Phe Gly 
                485                 490                 495     


Ser Phe Cys Pro Gly Gly Ser Ile Lys Gln Ile Gln Val Lys Gln Asn 
            500                 505                 510         


Ile Ser Val Thr Leu Arg Thr Phe Ala Pro Ser Phe Gln Gln Glu Ala 
        515                 520                 525             


Ser Arg Gln Gly Leu Thr Val Ser Phe Ile Pro Tyr Phe Lys Glu Glu 
    530                 535                 540                 


Gly Val Phe Thr Val Thr Pro Asp Thr Lys Ser Lys Val Tyr Leu Arg 
545                 550                 555                 560 


Thr Pro Asn Trp Asp Arg Gly Leu Pro Ser Leu Thr Ser Val Ser Trp 
                565                 570                 575     


Asn Ile Ser Val Pro Arg Asp Gln Val Ala Cys Leu Thr Phe Phe Lys 
            580                 585                 590         


Glu Arg Ser Gly Val Val Cys Gln Thr Gly Arg Ala Phe Met Ile Ile 
        595                 600                 605             


Gln Glu Gln Arg Thr Arg Ala Glu Glu Ile Phe Ser Leu Asp Glu Asp 
    610                 615                 620                 


Val Leu Pro Lys Pro Ser Phe His His His Ser Phe Trp Val Asn Ile 
625                 630                 635                 640 


Ser Asn Cys Ser Pro Thr Ser Gly Lys Gln Leu Asp Leu Leu Phe Ser 
                645                 650                 655     


Val Thr Leu Thr Pro Arg Thr Val Asp Leu Thr Val Ile Leu Ile Ala 
            660                 665                 670         


Ala Val Gly Gly Gly Val Leu Leu Leu Ser Ala Leu Gly Leu Ile Ile 
        675                 680                 685             


Cys Cys Val Lys Lys Lys Lys Lys Lys Thr Asn Lys Gly Pro Ala Val 
    690                 695                 700                 


Gly Ile Tyr Asn Asp Asn Ile Asn Thr Glu Met Pro Arg Gln Pro Lys 
705                 710                 715                 720 


Lys Phe Gln Lys Gly Arg Lys Asp Asn Asp Ser His Val Tyr Ala Val 
                725                 730                 735     


Ile Glu Asp Thr Met Val Tyr Gly His Leu Leu Gln Asp Ser Ser Gly 
            740                 745                 750         


Ser Phe Leu Gln Pro Glu Val Asp Thr Tyr Arg Pro Phe Gln Gly Thr 
        755                 760                 765             


Met Gly Val Cys Pro Pro Ser Pro Pro Thr Ile Cys Ser Arg Ala Pro 
    770                 775                 780                 


Thr Ala Lys Leu Ala Thr Glu Glu Pro Pro Pro Arg Ser Pro Pro Glu 
785                 790                 795                 800 


Ser Glu Ser Glu Pro Tyr Thr Phe Ser His Pro Asn Asn Gly Asp Val 
                805                 810                 815     


Ser Ser Lys Asp Thr Asp Ile Pro Leu Leu Asn Thr Gln Glu Pro Met 
            820                 825                 830         


Glu Pro Ala Glu 
        835     


<210>  9362
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Src-Kinases__Homo_sapiens__AAO34538

<400>  9362
auggccggcc ugaacugcgg ggucucuauc gcacugcuag ggguucugcu gcugggugcg       60

gcgcgccugc cgcgcggggc agaagcuuuu gagauugcuc ugccacgaga aagcaacauu      120

acaguucuca uaaagcuggg gaccccgacu cugcuggcaa aacccuguua caucgucauu      180

ucuaaaagac auauaaccau guuguccauc aagucuggag aaagaauagu cuuuaccuuu      240

agcugccaga guccugagaa ucacuuuguc auagagaucc agaaaaauau ugacuguaug      300

ucaggcccau guccuuuugg ggagguucag cuucagcccu cgacaucguu guugccuacc      360

cucaacagaa cuuucaucug ggaugucaaa gcucauaaga gcaucgguuu agagcugcag      420

uuuuccaucc cucgccugag gcagaucggu ccgggugaga gcugcccaga cggagucacu      480

cacuccauca gcggccgaau cgaugccacc guggucagga ucggaaccuu cugcagcaau      540

ggcacugugu cccggaucaa gaugcaagaa ggagugaaaa uggccuuaca ccucccaugg      600

uuccacccca gaaaugucuc cggcuucagc auugcaaacc gcucaucuau aaaacgucug      660

ugcaucaucg agucuguguu ugagggugaa ggcucagcaa cccugauguc ugccaacuac      720

ccagaaggcu ucccugagga ugagcucaug acguggcagu uugucguucc ugcacaccug      780

cgggccagcg ucuccuuccu caacuucaac cucuccaacu gugagaggaa ggaggagcgg      840

guugaauacu acaucccggg cuccaccacc aaccccgagg uguucaagcu ggaggacaag      900

cagccuggga acauggcggg gaacuucaac cucucucugc aaggcuguga ccaagaugcc      960

caaaguccag ggauccuccg gcugcaguuc caaguuuugg uccaacaucc acaaaaugaa     1020

agcaauaaaa ucuacguggu ugacuugagu aaugagcgag ccaugucacu caccaucgag     1080

ccacggcccg ucaaacagag ccgcaaguuu gucccuggcu guuucgugug ucuagaaucu     1140

cggaccugca guagcaaccu cacccugaca ucuggcucca aacacaaaau cuccuuccuu     1200

ugugaugauc ugacacgucu guggaugaau guggaaaaaa ccauaagcug cacagaccac     1260

cgguacugcc aaaggaaauc cuacucacuc caggugccca gugacauccu ccaccugccu     1320

guggagcugc augacuucuc cuggaagcug cuggugccca aggacaggcu cagccuggug     1380

cuggugccag cccagaagcu gcagcagcau acacacgaga agcccugcaa caccagcuuc     1440

agcuaccucg uggccagugc cauacccagc caggaccugu acuucggcuc cuucugcccg     1500

ggaggcucua ucaagcagau ccaggugaag cagaacaucu cggugacccu ucgcaccuuu     1560

gcccccagcu uccaacaaga ggccuccagg cagggucuga cgguguccuu uauaccuuau     1620

uucaaagagg aaggcguuuu cacggugacc ccugacacaa aaagcaaggu cuaccugagg     1680

acccccaacu gggaccgggg ccugccaucc cucaccucug uguccuggaa caucagcgug     1740

cccagagacc agguggccug ccugacuuuc uuuaaggagc ggagcggcgu ggucugccag     1800

acagggcgcg cauucaugau cauccaggag cagcggaccc gggcugagga gaucuucagc     1860

cuggacgagg augugcuccc caagccaagc uuccaccauc acagcuucug ggucaacauc     1920

ucuaacugca gccccacgag cggcaagcag cuagaccugc ucuucucggu gacacuuacc     1980

ccaaggacug uggacuugac ugucauccuc aucgcagcgg ugggaggugg agucuuacug     2040

cugucugccc ucgggcucau cauuugcugu gugaaaaaga agaaaaagaa gacaaacaag     2100

ggccccgcug uggguaucua caaugacaac aucaauacug agaugccgag gcagccaaaa     2160

aaguuucaga aagggcgaaa ggacaaugac ucccaugugu augcagucau cgaggacacc     2220

augguauaug ggcaucugcu acaggauucc agcggcuccu uccugcagcc agagguggac     2280

accuaccggc cguuccaggg caccaugggg gucuguccuc ccuccccacc caccauaugc     2340

uccagggccc caacugcaaa guuggccacu gaggagccac cuccucgcuc cccuccugag     2400

ucugagagug aaccguacac cuucucccau cccaacaaug gggauguaag cagcaaggac     2460

acagacauuc ccuuacugaa cacucaggag cccauggagc cagcagaaua a              2511


<210>  9363
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Src-Kinases__Homo_sapiens__AAO34538

<400>  9363
auggccggcc ugaacugcgg ggugagcauc gcccuccugg gcguccugcu ccugggggcg       60

gcccgccugc cccggggcgc cgaggccuuc gagaucgccc ucccgcgcga guccaacauc      120

accgugcuga ucaagcuggg gacccccacg cuccuggcga agcccugcua caucgugauc      180

agcaagcggc acaucaccau gcuguccauc aagagcggcg agcgcaucgu cuucaccuuc      240

uccugccaga gccccgagaa ccacuucgug aucgagaucc agaagaacau cgacugcaug      300

uccggcccgu gccccuucgg ggaggugcag cuccagccca gcaccucccu gcugcccacg      360

cucaaccgga ccuucaucug ggacgucaag gcccacaaga gcaucggccu ggagcugcag      420

uucuccaucc cgcgccuccg gcagaucggg cccggcgaga gcugccccga cggggugacc      480

cacuccauca gcggccgcau cgacgccacc gugguccgga ucggcacguu cugcuccaac      540

gggaccguga gccgcaucaa gaugcaggag ggcgugaaga uggcccugca ccuccccugg      600

uuccacccgc ggaacgucuc cggguucagc aucgcgaacc gcuccagcau caagcggcug      660

ugcaucaucg agagcguguu cgagggcgag ggcuccgcca cccugaugag cgccaacuac      720

cccgaggggu uccccgagga cgagcugaug accuggcagu ucgugguccc cgcccaccuc      780

cgcgccuccg ugagcuuccu gaacuucaac cuguccaacu gcgagcggaa ggaggagcgc      840

guggaguacu acaucccggg cagcacgacc aaccccgagg ucuucaagcu cgaggacaag      900

cagcccggga acauggcggg caacuucaac cugucccugc aggggugcga ccaggacgcc      960

cagagccccg gcauccuccg gcugcaguuc caggugcugg ugcagcaccc gcagaacgag     1020

uccaacaaga ucuacgucgu ggaccucagc aacgagcgcg ccaugucccu gaccaucgag     1080

ccccggcccg ugaagcagag ccgcaaguuc guccccggcu gcuucgugug ccuggagucc     1140

cggaccugca gcuccaaccu cacgcugacc agcgggucca agcacaagau cagcuuccug     1200

ugcgacgacc ucacccgccu guggaugaac gucgagaaga ccaucuccug cacggaccac     1260

cgcuacugcc agcgcaagag cuacagccuc caggugccgu ccgacauccu gcaccucccc     1320

guggagcugc acgacuucag cuggaagcug cuggucccca aggaccggcu gucccucgug     1380

cuggugcccg cccagaagcu gcagcagcac acccacgaga agccgugcaa caccagcuuc     1440

uccuaccugg ucgccagcgc gauccccucc caggaccucu acuucggcag cuucugcccc     1500

gggggcucca ucaagcagau ccaggugaag cagaacauca gcgugacccu gcggacguuc     1560

gccccguccu uccagcagga ggccagccgc caggggcuga ccgucuccuu cauccccuac     1620

uucaaggagg agggcguguu caccgugacc cccgacacca agagcaaggu cuaccuccgg     1680

acgcccaacu gggaccgcgg ccugccgucc cugaccagcg uguccuggaa caucagcgug     1740

ccccgggacc aggucgccug ccucaccuuc uucaaggagc gcagcggggu ggugugccag     1800

acgggccggg ccuucaugau cauccaggag cagcgcaccc gggcggagga gaucuucucc     1860

cuggacgagg acguccugcc caagcccagc uuccaccacc acuccuucug ggugaacauc     1920

agcaacugcu ccccgaccag cgggaagcag cucgaccugc uguucuccgu gacccucacg     1980

ccccgcaccg ucgaccugac cgugauccug aucgccgccg ugggcggggg cguccuccug     2040

cugagcgccc ucggccugau caucugcugc gugaagaaga agaagaagaa gaccaacaag     2100

gggcccgccg ugggcaucua caacgacaac aucaacaccg agaugccccg gcagccgaag     2160

aaguuccaga aggggcgcaa ggacaacgac ucccacgucu acgcggugau cgaggacacg     2220

augguguacg gccaccuccu gcaggacagc uccggcagcu uccugcagcc cgaggucgac     2280

accuaccggc ccuuccaggg gaccaugggc gugugcccgc ccuccccgcc caccaucugc     2340

agccgcgccc ccacggccaa gcuggccacc gaggagcccc cgccccgguc cccgcccgag     2400

agcgaguccg agcccuacac cuucagccac cccaacaacg gggacguguc cagcaaggac     2460

accgacaucc cccuccugaa cacgcaggag cccauggagc ccgcggagug a              2511


<210>  9364
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Src-Kinases__Homo_sapiens__AAO34538

<400>  9364
auggccggcc ucaacugcgg cgucuccauc gcccuccucg gcguccuccu ccucggcgcc       60

gcccgccucc cccgcggcgc cgaggccuuc gagaucgccc ucccccgcga guccaacauc      120

accguccuca ucaagcucgg cacccccacc cuccucgcca agcccugcua caucgucauc      180

uccaagcgcc acaucaccau gcucuccauc aaguccggcg agcgcaucgu cuucaccuuc      240

uccugccagu cccccgagaa ccacuucguc aucgagaucc agaagaacau cgacugcaug      300

uccggccccu gccccuucgg cgagguccag cuccagcccu ccaccucccu ccuccccacc      360

cucaaccgca ccuucaucug ggacgucaag gcccacaagu ccaucggccu cgagcuccag      420

uucuccaucc cccgccuccg ccagaucggc cccggcgagu ccugccccga cggcgucacc      480

cacuccaucu ccggccgcau cgacgccacc gucguccgca ucggcaccuu cugcuccaac      540

ggcaccgucu cccgcaucaa gaugcaggag ggcgucaaga uggcccucca ccuccccugg      600

uuccaccccc gcaacgucuc cggcuucucc aucgccaacc gcuccuccau caagcgccuc      660

ugcaucaucg aguccgucuu cgagggcgag ggcuccgcca cccucauguc cgccaacuac      720

cccgagggcu uccccgagga cgagcucaug accuggcagu ucgucguccc cgcccaccuc      780

cgcgccuccg ucuccuuccu caacuucaac cucuccaacu gcgagcgcaa ggaggagcgc      840

gucgaguacu acauccccgg cuccaccacc aaccccgagg ucuucaagcu cgaggacaag      900

cagcccggca acauggccgg caacuucaac cucucccucc agggcugcga ccaggacgcc      960

cagucccccg gcauccuccg ccuccaguuc cagguccucg uccagcaccc ccagaacgag     1020

uccaacaaga ucuacgucgu cgaccucucc aacgagcgcg ccaugucccu caccaucgag     1080

ccccgccccg ucaagcaguc ccgcaaguuc guccccggcu gcuucgucug ccucgagucc     1140

cgcaccugcu ccuccaaccu cacccucacc uccggcucca agcacaagau cuccuuccuc     1200

ugcgacgacc ucacccgccu cuggaugaac gucgagaaga ccaucuccug caccgaccac     1260

cgcuacugcc agcgcaaguc cuacucccuc cagguccccu ccgacauccu ccaccucccc     1320

gucgagcucc acgacuucuc cuggaagcuc cucgucccca aggaccgccu cucccucguc     1380

cucguccccg cccagaagcu ccagcagcac acccacgaga agcccugcaa caccuccuuc     1440

uccuaccucg ucgccuccgc cauccccucc caggaccucu acuucggcuc cuucugcccc     1500

ggcggcucca ucaagcagau ccaggucaag cagaacaucu ccgucacccu ccgcaccuuc     1560

gcccccuccu uccagcagga ggccucccgc cagggccuca ccgucuccuu cauccccuac     1620

uucaaggagg agggcgucuu caccgucacc cccgacacca aguccaaggu cuaccuccgc     1680

acccccaacu gggaccgcgg ccuccccucc cucaccuccg ucuccuggaa caucuccguc     1740

ccccgcgacc aggucgccug ccucaccuuc uucaaggagc gcuccggcgu cgucugccag     1800

accggccgcg ccuucaugau cauccaggag cagcgcaccc gcgccgagga gaucuucucc     1860

cucgacgagg acguccuccc caagcccucc uuccaccacc acuccuucug ggucaacauc     1920

uccaacugcu cccccaccuc cggcaagcag cucgaccucc ucuucuccgu cacccucacc     1980

ccccgcaccg ucgaccucac cgucauccuc aucgccgccg ucggcggcgg cguccuccuc     2040

cucuccgccc ucggccucau caucugcugc gucaagaaga agaagaagaa gaccaacaag     2100

ggccccgccg ucggcaucua caacgacaac aucaacaccg agaugccccg ccagcccaag     2160

aaguuccaga agggccgcaa ggacaacgac ucccacgucu acgccgucau cgaggacacc     2220

auggucuacg gccaccuccu ccaggacucc uccggcuccu uccuccagcc cgaggucgac     2280

accuaccgcc ccuuccaggg caccaugggc gucugccccc ccuccccccc caccaucugc     2340

ucccgcgccc ccaccgccaa gcucgccacc gaggagcccc ccccccgcuc cccccccgag     2400

uccgaguccg agcccuacac cuucucccac cccaacaacg gcgacgucuc cuccaaggac     2460

accgacaucc cccuccucaa cacccaggag cccauggagc ccgccgagug a              2511


<210>  9365
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Src-Kinases__Homo_sapiens__AAO34538

<400>  9365
auggccggcc ugaacugcgg ggugagcauc gcucuccuug gaguccuguu guuaggugca       60

gccagacugc ccaggggcgc ggaggcuuuc gaaauugccc uaccucggga guccaauaua      120

accguucuca ucaagcuggg gacaccaacu cuucuggcaa aaccguguua cauugugauc      180

ucuaagcgcc acauuacgau guugucaauc aaaaguggag aacgaauagu auuuaccuuc      240

agcugccagu cccccgagaa ccauuuugug aucgaaauuc aaaagaauau cgacuguaug      300

ucuggcccuu gcccauucgg ugagguccag cuccagcccu cgacaucacu gcugccuacu      360

cucaaccgua ccuuuauuug ggaugugaaa gcccacaaga gcaucggguu agagcugcag      420

uucaguauac caagacuuag gcaaauugga cccggcgaau ccuguccuga cggcguuaca      480

cauucuauca gcgggcggau ugaugcuacc gugguccgca ucggaacuuu uugcuccaau      540

gguacagugu caagaaucaa gaugcaggag ggcguaaaaa uggcauugca ucugccaugg      600

uuccacccga ggaacguuag uggguuuagc auugccaauc ggucuuccau aaagcgccua      660

uguaucauug aaucaguguu cgagggagag ggcagcgcua cccucaugag ugccaacuau      720

cccgaagguu uuccugagga cgaacugaug acguggcagu ucgucgugcc agcgcaccuu      780

cgagcaucug uguccuuucu gaauuucaac uugagcaauu gcgagagaaa agaagagagg      840

gucgaguacu auauccccgg gucgacuacc aacccugaag uuuucaagcu cgaggauaaa      900

cagccaggaa auauggccgg caacuuuaau cugucuuuac aaggcuguga ccaggaugcu      960

cagucccccg ggauacugcg gcuccaguuc caagugcuug uacagcaccc gcagaacgaa     1020

ucaaacaaga uuuacguggu cgaccugagu aaugagcgug ccaugagcuu gacaaucgaa     1080

ccucgccccg ugaagcaauc cagaaaauuu guuccaggau gcuucgugug ucuagagucu     1140

aggacuugca gcucaaaccu gacccucaca agugguucca agcauaaaau cagcuuucug     1200

ugcgaugacc uuacccggcu guggaugaau gucgagaaga cgauuucuug uacugaucac     1260

cgauauugcc agcgcaaauc auacagucuc caggugccua gcgacaucuu gcaucugccc     1320

guagaauuac acgauuucuc cuggaagcug cuaguuccaa aagacagacu cucucuggug     1380

cuuguccccg cacagaaguu gcaacagcac acacaugaga agccuuguaa caccucguuu     1440

agcuaucugg uggcuuccgc cauuccauca caggaccucu acuucggcag uuuuugcccc     1500

gggggaucua uaaaacagau ccaagucaag cagaauauua gcgugacucu gaggacauuc     1560

gcgcccuccu uucagcagga agccucacgg caaggccuua ccguuagcuu caucccuuac     1620

uuuaaagagg aagguguguu cacgguaacc ccagauacaa agucuaaagu cuaucugcgc     1680

acucccaacu gggacagagg guugccuucc cucaccagug ugagcuggaa uaucucuguu     1740

ccaagggauc agguggcaug ucugacauuc uuuaaggagc guuccggcgu cgugugccag     1800

acuggacggg cuuucaugau uauacaggag caacgaacca gagccgaaga gaucuuuuca     1860

uuagacgaag auguacugcc caagccgagu uuccaccauc acagcuuuug ggugaacauu     1920

ucgaauuguu ccccuacauc uggcaaacag cuagaccucc uguucagcgu uacccuuacu     1980

ccaaggacgg ucgauuugac agugauccug auugcugccg ucgggggagg ugugcuccug     2040

uuaucagcac ugggccuuau cauaugcugu guuaagaaaa agaaaaagaa gaccaacaaa     2100

gggcccgccg ugggaaucua caaugacaac auuaauacug agaugccucg ccagcccaag     2160

aaauuucaaa agggccggaa agauaacgac agucaugugu augcuguaau cgaggauacc     2220

auggucuacg gucacuugcu ccaggacucc ucugggagcu uccugcagcc agaaguggac     2280

acauauagac cuuuucaggg caccauggga guuugcccgc cauccccgcc uacuauuugu     2340

ucaagggcgc ccacagcaaa gcuagccacg gaggaaccac ccccucgcag cccacccgag     2400

agugaaucug agccuuacac cuucucccac ccgaauaacg gcgaugugag cucgaaggac     2460

acugauaucc cacugcucaa cacacaagag cccauggaac cugcugagug a              2511


<210>  9366
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Src-Kinases__Homo_sapiens__AAO34538

<400>  9366
auggccggcc ugaacugcgg cgugagcauc gcccugcugg gcgugcugcu gcugggcgcc       60

gccagacugc ccagaggcgc cgaggccuuc gagaucgccc ugcccagaga gagcaacauc      120

accgugcuga ucaagcuggg cacccccacc cugcuggcca agcccugcua caucgugauc      180

agcaagagac acaucaccau gcugagcauc aagagcggcg agagaaucgu guucaccuuc      240

agcugccaga gccccgagaa ccacuucgug aucgagaucc agaagaacau cgacugcaug      300

agcggccccu gccccuucgg cgaggugcag cugcagccca gcaccagccu gcugcccacc      360

cugaacagaa ccuucaucug ggacgugaag gcccacaaga gcaucggccu ggagcugcag      420

uucagcaucc ccagacugag acagaucggc cccggcgaga gcugccccga cggcgugacc      480

cacagcauca gcggcagaau cgacgccacc guggugagaa ucggcaccuu cugcagcaac      540

ggcaccguga gcagaaucaa gaugcaggag ggcgugaaga uggcccugca ccugcccugg      600

uuccacccca gaaacgugag cggcuucagc aucgccaaca gaagcagcau caagagacug      660

ugcaucaucg agagcguguu cgagggcgag ggcagcgcca cccugaugag cgccaacuac      720

cccgagggcu uccccgagga cgagcugaug accuggcagu ucguggugcc cgcccaccug      780

agagccagcg ugagcuuccu gaacuucaac cugagcaacu gcgagagaaa ggaggagaga      840

guggaguacu acauccccgg cagcaccacc aaccccgagg uguucaagcu ggaggacaag      900

cagcccggca acauggccgg caacuucaac cugagccugc agggcugcga ccaggacgcc      960

cagagccccg gcauccugag acugcaguuc caggugcugg ugcagcaccc ccagaacgag     1020

agcaacaaga ucuacguggu ggaccugagc aacgagagag ccaugagccu gaccaucgag     1080

cccagacccg ugaagcagag cagaaaguuc gugcccggcu gcuucgugug ccuggagagc     1140

agaaccugca gcagcaaccu gacccugacc agcggcagca agcacaagau cagcuuccug     1200

ugcgacgacc ugaccagacu guggaugaac guggagaaga ccaucagcug caccgaccac     1260

agauacugcc agagaaagag cuacagccug caggugccca gcgacauccu gcaccugccc     1320

guggagcugc acgacuucag cuggaagcug cuggugccca aggacagacu gagccuggug     1380

cuggugcccg cccagaagcu gcagcagcac acccacgaga agcccugcaa caccagcuuc     1440

agcuaccugg uggccagcgc cauccccagc caggaccugu acuucggcag cuucugcccc     1500

ggcggcagca ucaagcagau ccaggugaag cagaacauca gcgugacccu gagaaccuuc     1560

gcccccagcu uccagcagga ggccagcaga cagggccuga ccgugagcuu cauccccuac     1620

uucaaggagg agggcguguu caccgugacc cccgacacca agagcaaggu guaccugaga     1680

acccccaacu gggacagagg ccugcccagc cugaccagcg ugagcuggaa caucagcgug     1740

cccagagacc agguggccug ccugaccuuc uucaaggaga gaagcggcgu ggugugccag     1800

accggcagag ccuucaugau cauccaggag cagagaacca gagccgagga gaucuucagc     1860

cuggacgagg acgugcugcc caagcccagc uuccaccacc acagcuucug ggugaacauc     1920

agcaacugca gccccaccag cggcaagcag cuggaccugc uguucagcgu gacccugacc     1980

cccagaaccg uggaccugac cgugauccug aucgccgccg ugggcggcgg cgugcugcug     2040

cugagcgccc ugggccugau caucugcugc gugaagaaga agaagaagaa gaccaacaag     2100

ggccccgccg ugggcaucua caacgacaac aucaacaccg agaugcccag acagcccaag     2160

aaguuccaga agggcagaaa ggacaacgac agccacgugu acgccgugau cgaggacacc     2220

augguguacg gccaccugcu gcaggacagc agcggcagcu uccugcagcc cgagguggac     2280

accuacagac ccuuccaggg caccaugggc gugugccccc ccagcccccc caccaucugc     2340

agcagagccc ccaccgccaa gcuggccacc gaggagcccc cccccagaag cccccccgag     2400

agcgagagcg agcccuacac cuucagccac cccaacaacg gcgacgugag cagcaaggac     2460

accgacaucc cccugcugaa cacccaggag cccauggagc ccgccgagug a              2511


<210>  9367
<211>  2511
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Src-Kinases__Homo_sapiens__AAO34538

<400>  9367
auggccggcc ugaacugcgg ggugagcauc gcucuccugg gaguccuucu gcucggcgcc       60

gcgagacugc cccggggagc ugaggccuuc gaaauugccc uuccucgcga guccaauauc      120

accguucuga uuaagcucgg aacaccgacg cugcuggcua aacccuguua caucgugauu      180

ucuaagagac acaucaccau gcucagcauc aaauccggcg aacggauugu guuuacauuc      240

ucuugccaga gcccugagaa ccacuuuguc aucgaaauuc aaaagaauau cgacuguaug      300

uccgggcccu gcccuuucgg agaggugcag cugcagcccu cuaccagccu ucugccuaca      360

cucaaccgca ccuuuauuug ggauguuaaa gcccacaagu ccaucggccu ggagcuucag      420

uucagcauuc cgagacugcg gcaaaucggc cccggggaau cuuguccuga cggagugaca      480

cauuccauca gcggccgcau ugaugcuacc gucgugagaa ucgggacguu uugcucuaau      540

ggaaccguuu cccggauuaa gaugcaggag ggcgugaaaa uggcccucca ucugcccugg      600

uuccacccuc gcaacgucag cggguuuucu aucgcgaaua gauccagcau uaagcggcug      660

uguaucaucg aauccguguu cgagggagag ggcucugcca cacucaugag cgcuaacuau      720

cccgaaggcu uuccggagga cgaacugaug accuggcagu ucgugguccc ugcccaccuu      780

cgcgcuuccg uuagcuuucu gaauuucaac cucucuaauu gcgagagaaa agaggaacgg      840

guggaguacu auauucccgg guccacaacc aacccugaag uguucaagcu ggaggauaaa      900

cagcccggaa auauggccgg caacuuuaau cuuagccugc aaggguguga ccaggaugcg      960

cagucucccg gaauccuccg ccugcaguuc caaguccugg ugcagcaccc ucagaacgaa     1020

agcaacaaga uuuacguugu ggaccucucc aaugagagag ccaugucucu gacgaucgaa     1080

ccgcggcccg ucaagcaaag cagaaaauuu gugccuggcu gcuucguuug ucuugagucc     1140

cgcacaugca gcucuaaccu gacccucaca uccgggagca agcauaaaau uucuuuucug     1200

ugcgaugacc uuacccggcu guggaugaau guggagaaga ccaucuccug uacagaucac     1260

agauauugcc agcgcaaaag cuacucccuc cagguccccu cugacauccu gcaucugccu     1320

guggaacucc acgauuucag cuggaagcug cuugucccca aagaccggcu gucccucgug     1380

cugguuccgg cucagaagcu gcaacagcac acgcaugaga agccuuguaa caccucuuuu     1440

agcuaucuug uggccuccgc uauucccagc caggaccucu acuucggauc uuuuugcccu     1500

ggcggcucca ucaaacagau ucaagucaag cagaauauca gcgugacacu gagaaccuuc     1560

gcccccucuu uucagcagga agccucccgc caagggcuga caguuagcuu cauuccuuac     1620

uuuaaagagg aaggaguguu caccgucacg cccgauacaa agucuaaagu guaucuccgg     1680

accccgaacu gggacagagg ccugccuagc cuuaccuccg ugagcuggaa uaucucuguu     1740

ccccgcgauc aggucgcuug ucugacauuc uuuaaggagc gguccggggu ggugugccag     1800

accgggagag cguucaugau uauccaggag caacgcacac gggccgaaga gaucuuuagc     1860

cucgacgaag auguccugcc caagccuucc uuccaccauc acucuuuuug ggugaacauu     1920

agcaauuguu ccccgacguc uggcaaacag cuggaccuuc ucuucagcgu uacccugaca     1980

cccagaaccg uggaucugac agucauccuc auugcugccg ugggaggcgg aguucugcuu     2040

cuguccgccc ucggccugau cauuugcugu gugaagaaaa agaaaaagaa gaccaacaaa     2100

gggccugcug ucggaaucua caaugacaac aucaauacgg agaugccccg gcagccuaag     2160

aaauuucaaa agggccgcaa agauaacgac ucucaugugu augccguuau ugaggauacc     2220

augguguacg ggcaucugcu ucaggacagc uccgggagcu uccuccagcc cgaagucgac     2280

acauauagac cuuuucaggg caccaugggg gugugucccc cgucuccucc cacaaucugc     2340

ucccgggcgc cuaccgcuaa gcuggccacg gaggaacccc cgccuagauc ucccccugag     2400

agcgaauccg agcccuacac auucagccac cccaauaacg gcgauguguc uuccaaggac     2460

accgauauuc cucugcucaa cacacaagag ccgauggaac ccgccgagug a              2511


<210>  9368
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_A__Homo_sapiens__Q8IWL1

<400>  9368

Met Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Val Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Glu Thr Pro Cys Pro Pro Gly Asn Asn Gly Leu Pro Gly Ala Pro Gly 
65                  70                  75                  80  


Val Pro Gly Glu Arg Gly Glu Lys Gly Glu Ala Gly Glu Arg Gly Pro 
                85                  90                  95      


Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 
            100                 105                 110         


Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 
    130                 135                 140                 


Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 
145                 150                 155                 160 


Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 
            180                 185                 190         


Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Ile Cys Glu Phe 
                245             


<210>  9369
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9369
auguggcugu gcccucuggc ccucaaccuc aucuugaugg cagccucugg ugcugcgugc       60

gaagugaagg acguuugugu uggaagcccu gguauccccg gcacuccugg aucccacggc      120

cugccaggca gggacgggag agaugguguc aaaggagacc cuggcccucc aggccccaug      180

gguccgccug gagaaacacc auguccuccu gggaauaaug ggcugccugg agccccuggu      240

gucccuggag agcguggaga gaagggggag gcuggcgaga gaggcccucc agggcuucca      300

gcucaucuag augaggagcu ccaagccaca cuccacgacu ucagacauca aauccugcag      360

acaaggggag cccucagucu gcagggcucc auaaugacag uaggagagaa ggucuucucc      420

agcaaugggc aguccaucac uuuugaugcc auucaggagg caugugccag agcaggcggc      480

cgcauugcug ucccaaggaa uccagaggaa aaugaggcca uugcaagcuu cgugaagaag      540

uacaacacau augccuaugu aggccugacu gaggguccca gcccuggaga cuuccgcuac      600

ucagauggga ccccuguaaa cuacaccaac ugguaccgag gggagccugc aggucgggga      660

aaagagcagu guguggagau guacacagau gggcagugga augacaggaa cugccuguac      720

ucccgacuga ccaucuguga guucuga                                          747


<210>  9370
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9370
auguggcugu gcccccucgc ccugaaccug auccucaugg ccgcgagcgg cgccgccugc       60

gaggugaagg acgucugcgu gggguccccg ggcauccccg ggacccccgg cagccacggg      120

cugcccggcc gcgacggccg ggacggggug aagggcgacc cggggccgcc cggccccaug      180

gggccgcccg gcgagacccc cugcccgccc ggcaacaacg ggcugcccgg cgcccccggg      240

guccccggcg agcgcggcga gaagggggag gccggcgagc gggggccgcc cggccucccc      300

gcgcaccugg acgaggagcu gcaggccacg cuccacgacu uccgccacca gauccugcag      360

acccgcgggg cccugucccu ccagggcagc aucaugaccg ugggcgagaa gguguucucc      420

agcaacgggc aguccaucac cuucgacgcc auccaggagg cgugcgcccg ggccggcggg      480

cggaucgccg ucccccgcaa ccccgaggag aacgaggcca ucgcgagcuu cgugaagaag      540

uacaacacgu acgccuacgu gggccugacc gaggggcccu cccccggcga cuuccgguac      600

agcgacggca cccccgucaa cuacaccaac ugguaccgcg gggagccggc cggccggggg      660

aaggagcagu gcguggagau guacacggac ggccagugga acgaccgcaa cugccuguac      720

ucccggcuca ccaucugcga guucuga                                          747


<210>  9371
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9371
auguggcucu gcccccucgc ccucaaccuc auccucaugg ccgccuccgg cgccgccugc       60

gaggucaagg acgucugcgu cggcuccccc ggcauccccg gcacccccgg cucccacggc      120

cuccccggcc gcgacggccg cgacggcguc aagggcgacc ccggcccccc cggccccaug      180

ggcccccccg gcgagacccc cugccccccc ggcaacaacg gccuccccgg cgcccccggc      240

guccccggcg agcgcggcga gaagggcgag gccggcgagc gcggcccccc cggccucccc      300

gcccaccucg acgaggagcu ccaggccacc cuccacgacu uccgccacca gauccuccag      360

acccgcggcg cccucucccu ccagggcucc aucaugaccg ucggcgagaa ggucuucucc      420

uccaacggcc aguccaucac cuucgacgcc auccaggagg ccugcgcccg cgccggcggc      480

cgcaucgccg ucccccgcaa ccccgaggag aacgaggcca ucgccuccuu cgucaagaag      540

uacaacaccu acgccuacgu cggccucacc gagggccccu cccccggcga cuuccgcuac      600

uccgacggca cccccgucaa cuacaccaac ugguaccgcg gcgagcccgc cggccgcggc      660

aaggagcagu gcgucgagau guacaccgac ggccagugga acgaccgcaa cugccucuac      720

ucccgccuca ccaucugcga guucuga                                          747


<210>  9372
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9372
auguggcugu gcccccucgc ccuuaaccug aucuugaugg cugcaagcgg cgccgcgugu       60

gaggugaagg acgucugcgu uggguccccu gguauuccag gaaccccggg cucucacggg      120

uuacccggaa gagauggcag ggacggugug aaaggggauc cuggaccacc cggcccuaug      180

ggcccacccg gggaaacacc uuguccaccg ggaaauaacg gucugcccgg cgcuccuggg      240

guaccaggag agcggggcga aaagggugag gccggggaac gcggaccccc uggccuacca      300

gcacaucucg acgaggagcu gcaggccacu cuucacgauu uccgacauca aauacugcag      360

acgcguggcg cuuugucacu ccaggggagu aucaugaccg ugggagaaaa agucuuuagc      420

uccaaugguc agucuauuac auucgacgca auccaagagg ccugcgcuag agccggcggg      480

aggauugcgg ugccccggaa cccggaagag aaugaggcaa ucgccucguu uguuaagaaa      540

uacaacacuu augcuuacgu gggacugacc gaaggcccuu cacccgguga uuuccgcuau      600

agcgacggga caccagucaa uuacaccaac ugguauagag gcgagccugc cggaaggggc      660

aaggaacagu guguggagau guacacugau gggcagugga augaccggaa cugccuguau      720

agucgccuca caauauguga auuuuga                                          747


<210>  9373
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9373
auguggcugu gcccccuggc ccugaaccug auccugaugg ccgccagcgg cgccgccugc       60

gaggugaagg acgugugcgu gggcagcccc ggcauccccg gcacccccgg cagccacggc      120

cugcccggca gagacggcag agacggcgug aagggcgacc ccggcccccc cggccccaug      180

ggcccccccg gcgagacccc cugccccccc ggcaacaacg gccugcccgg cgcccccggc      240

gugcccggcg agagaggcga gaagggcgag gccggcgaga gaggcccccc cggccugccc      300

gcccaccugg acgaggagcu gcaggccacc cugcacgacu ucagacacca gauccugcag      360

accagaggcg cccugagccu gcagggcagc aucaugaccg ugggcgagaa gguguucagc      420

agcaacggcc agagcaucac cuucgacgcc auccaggagg ccugcgccag agccggcggc      480

agaaucgccg ugcccagaaa ccccgaggag aacgaggcca ucgccagcuu cgugaagaag      540

uacaacaccu acgccuacgu gggccugacc gagggcccca gccccggcga cuucagauac      600

agcgacggca cccccgugaa cuacaccaac ugguacagag gcgagcccgc cggcagaggc      660

aaggagcagu gcguggagau guacaccgac ggccagugga acgacagaaa cugccuguac      720

agcagacuga ccaucugcga guucuga                                          747


<210>  9374
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Surfactant_protein_A__Homo_sapiens__AAI57867

<400>  9374
auguggcugu gcccccucgc ccugaaccuu auccugaugg cugccagcgg cgcggcuugu       60

gaggugaagg acgucugcgu uggguccccu gggauuccgg gcacccccgg gucucacgga      120

cucccuggca gagaugggcg ggacggagug aaaggcgauc ccggcccucc cgggccuaug      180

ggaccgcccg gcgaaacacc uugucccccu gggaauaacg gacugcccgg cgccccgggg      240

gugccuggag agcgcggcga aaagggcgag gccggggaaa gaggaccccc uggccuuccc      300

gcucaucugg acgaggagcu ccaggccacg cugcacgauu uccggcauca aauccugcag      360

acccgcgggg cucucagccu gcagggaucc auuaugacag ucggcgaaaa aguguuuucu      420

agcaaugggc aguccaucac cuucgacgcc auucaagagg cgugcgccag agcuggaggc      480

cggaucgccg uuccccgcaa cccugaagag aaugaggcua ucgccucuuu ugugaagaaa      540

uacaacacau augcguacgu cggccuuacc gaagggccga gccccggaga uuucagauau      600

uccgacggca caccugugaa uuacaccaac ugguaucggg gagagcccgc cggacgcggc      660

aaggaacagu guguugagau guacacggau gggcagugga augacagaaa cugccuguau      720

agccggcuca ccauuuguga auuuuga                                          747


<210>  9375
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_A__Homo_sapiens__Q8IWL2

<400>  9375

Met Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Leu Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Glu Met Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro Gly Ala Pro Gly 
65                  70                  75                  80  


Ile Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro 
                85                  90                  95      


Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 
            100                 105                 110         


Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 
    130                 135                 140                 


Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 
145                 150                 155                 160 


Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 
            180                 185                 190         


Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Ile Cys Glu Phe 
                245             


<210>  9376
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9376
auguggcugu gcccucuggc ccucaaccuc aucuugaugg cagccucugg ugcugugugc       60

gaagugaagg acguuugugu uggaagcccu gguauccccg gcacuccugg aucccacggc      120

cugccaggca gggacgggag agauggucuc aaaggagacc cuggcccucc aggccccaug      180

gguccaccug gagaaaugcc auguccuccu ggaaaugaug ggcugccugg agccccuggu      240

aucccuggag aguguggaga gaagggggag ccuggcgaga ggggcccucc agggcuucca      300

gcucaucuag augaggagcu ccaagccaca cuccacgacu uuagacauca aauccugcag      360

acaaggggag cccucagucu gcagggcucc auaaugacag uaggagagaa ggucuucucc      420

agcaaugggc aguccaucac uuuugaugcc auucaggagg caugugccag agcaggcggc      480

cgcauugcug ucccaaggaa uccagaggaa aaugaggcca uugcaagcuu cgugaagaag      540

uacaacacau augccuaugu aggccugacu gaggguccca gcccuggaga cuuccgcuac      600

ucagacggga ccccuguaaa cuacaccaac ugguaccgag gggagcccgc aggucgggga      660

aaagagcagu guguggagau guacacagau gggcagugga augacaggaa cugccuguac      720

ucccgacuga ccaucuguga guucuga                                          747


<210>  9377
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9377
auguggcugu gcccccucgc ccugaaccug auccucaugg ccgcgagcgg cgccgugugc       60

gaggucaagg acgugugcgu gggguccccg ggcauccccg ggacccccgg cagccacggg      120

cugcccggcc gcgacggccg ggacgggcug aagggcgacc cggggccgcc cggccccaug      180

gggccgcccg gcgagaugcc cugcccgccc ggcaacgacg ggcuccccgg cgcccccggg      240

auccccggcg agugcggcga gaagggggag cccggcgagc gcgggccgcc cggccugccc      300

gcccaccugg acgaggagcu ccaggccacc cugcacgacu uccggcacca gauccugcag      360

acgcgcgggg cgcucucccu gcagggcagc aucaugaccg ucggcgagaa gguguucucc      420

agcaacgggc aguccaucac cuucgacgcc auccaggagg ccugcgcccg ggcgggcggg      480

cgcaucgccg ugccccggaa ccccgaggag aacgaggcca ucgccagcuu cgucaagaag      540

uacaacaccu acgccuacgu gggccugacg gaggggcccu cccccggcga cuuccgcuac      600

agcgacggca ccccggugaa cuacaccaac ugguaccgcg gggagcccgc gggccggggg      660

aaggagcagu gcgucgagau guacaccgac ggccagugga acgaccggaa cugccucuac      720

ucccgccuga cgaucugcga guucuga                                          747


<210>  9378
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9378
auguggcucu gcccccucgc ccucaaccuc auccucaugg ccgccuccgg cgccgucugc       60

gaggucaagg acgucugcgu cggcuccccc ggcauccccg gcacccccgg cucccacggc      120

cuccccggcc gcgacggccg cgacggccuc aagggcgacc ccggcccccc cggccccaug      180

ggcccccccg gcgagaugcc cugccccccc ggcaacgacg gccuccccgg cgcccccggc      240

auccccggcg agugcggcga gaagggcgag cccggcgagc gcggcccccc cggccucccc      300

gcccaccucg acgaggagcu ccaggccacc cuccacgacu uccgccacca gauccuccag      360

acccgcggcg cccucucccu ccagggcucc aucaugaccg ucggcgagaa ggucuucucc      420

uccaacggcc aguccaucac cuucgacgcc auccaggagg ccugcgcccg cgccggcggc      480

cgcaucgccg ucccccgcaa ccccgaggag aacgaggcca ucgccuccuu cgucaagaag      540

uacaacaccu acgccuacgu cggccucacc gagggccccu cccccggcga cuuccgcuac      600

uccgacggca cccccgucaa cuacaccaac ugguaccgcg gcgagcccgc cggccgcggc      660

aaggagcagu gcgucgagau guacaccgac ggccagugga acgaccgcaa cugccucuac      720

ucccgccuca ccaucugcga guucuga                                          747


<210>  9379
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9379
auguggcugu gcccccucgc ccuuaaccug aucuugaugg cugcaagcgg cgccgugugu       60

gaggucaagg acguuugcgu gggguccccu gguauuccag gaaccccggg cucucacggg      120

uuacccggaa gagauggcag ggacggucug aaaggggauc cuggaccacc cggcccuaug      180

ggcccacccg gggaaaugcc uuguccaccg ggaaaugacg gucuacccgg cgcgccuggg      240

auaccaggag agugcggcga aaagggugag cccggggaac ggggaccucc aggccucccc      300

gcucaucugg augaggagcu ucaggccaca cugcacgacu uccgccauca aaucuugcag      360

acucgaggcg cacucucacu gcaggggagu auuaugacgg uaggagaaaa aguguuuagc      420

uccaacgguc agucuaucac cuucgaugcc auucaagagg cuugugcacg ugccggcggg      480

agaaucgcug ucccgaggaa uccugaagag aacgaggcca uagcgucguu ugugaagaaa      540

uacaauacau augcauacgu uggacugacu gaaggccccu caccagguga cuuccgguau      600

agcgauggga ccccugugaa cuacacaaau ugguaucgcg gcgagcccgc cggaagaggc      660

aaggaacagu gcgucgagau guacaccgac gggcagugga acgauaggaa uugucucuau      720

agucgguuaa cuaucugcga auuuuga                                          747


<210>  9380
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9380
auguggcugu gcccccuggc ccugaaccug auccugaugg ccgccagcgg cgccgugugc       60

gaggugaagg acgugugcgu gggcagcccc ggcauccccg gcacccccgg cagccacggc      120

cugcccggca gagacggcag agacggccug aagggcgacc ccggcccccc cggccccaug      180

ggcccccccg gcgagaugcc cugccccccc ggcaacgacg gccugcccgg cgcccccggc      240

auccccggcg agugcggcga gaagggcgag cccggcgaga gaggcccccc cggccugccc      300

gcccaccugg acgaggagcu gcaggccacc cugcacgacu ucagacacca gauccugcag      360

accagaggcg cccugagccu gcagggcagc aucaugaccg ugggcgagaa gguguucagc      420

agcaacggcc agagcaucac cuucgacgcc auccaggagg ccugcgccag agccggcggc      480

agaaucgccg ugcccagaaa ccccgaggag aacgaggcca ucgccagcuu cgugaagaag      540

uacaacaccu acgccuacgu gggccugacc gagggcccca gccccggcga cuucagauac      600

agcgacggca cccccgugaa cuacaccaac ugguacagag gcgagcccgc cggcagaggc      660

aaggagcagu gcguggagau guacaccgac ggccagugga acgacagaaa cugccuguac      720

agcagacuga ccaucugcga guucuga                                          747


<210>  9381
<211>  747
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Surfactant_protein_A__Homo_sapiens__AAI11571

<400>  9381
auguggcugu gcccccucgc ccugaaccuu auccugaugg cugccagcgg cgcggugugu       60

gaggucaagg acguuugcgu gggguccccu gggauuccgg gcacccccgg gucucacgga      120

cucccuggca gagaugggcg ggacggacug aaaggcgauc ccggcccucc cgggccuaug      180

ggaccgcccg gcgaaaugcc uugucccccu gggaaugacg gacuucccgg cgcuccgggg      240

aucccuggag agugcggcga aaagggcgag cccggggaac gcggaccucc cggccugccc      300

gcccaucucg augaggagcu gcaggccaca cugcacgacu ucagacauca aauucuccag      360

acgcggggag cucugagccu ucagggaucc aucaugaccg ugggcgaaaa agucuuuucu      420

agcaacgggc aguccauuac auucgaugcc auccaagagg cuugugcccg cgcgggaggc      480

agaaucgccg ugccucggaa uccggaagag aacgaggcua uugccucuuu uguuaagaaa      540

uacaauaccu augcuuacgu gggccugaca gaagggccca gcccuggaga cuuccgcuau      600

uccgauggca cccccgucaa cuacacaaau ugguauagag gggagccugc cggacggggc      660

aaggaacagu gcguggagau guacaccgac gggcagugga acgaucgcaa uugucucuau      720

agcagacuga cgaucugcga auuuuga                                          747


<210>  9382
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_D__Homo_sapiens__P35247

<400>  9382

Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 
1               5                   10                  15      


Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 
            20                  25                  30          


Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln 
65                  70                  75                  80  


Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly 
            100                 105                 110         


Val Pro Gly Pro Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn 
        115                 120                 125             


Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys 
    130                 135                 140                 


Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 
145                 150                 155                 160 


Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val 
                165                 170                 175     


Pro Gly Asn Thr Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln 
            180                 185                 190         


Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly 
        195                 200                 205             


Ile Pro Gly Asp Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val 
    210                 215                 220                 


Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 
225                 230                 235                 240 


Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 
                245                 250                 255     


Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 
            260                 265                 270         


Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 
        275                 280                 285             


Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val 
    290                 295                 300                 


Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 
305                 310                 315                 320 


Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 
                325                 330                 335     


Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 
            340                 345                 350         


Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 
        355                 360                 365             


Arg Leu Val Val Cys Glu Phe 
    370                 375 


<210>  9383
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9383
augcugcucu uccuccucuc ugcacugguc cugcucacac agccccuggg cuaccuggaa       60

gcagaaauga agaccuacuc ccacagaaca augcccagug cuugcacccu ggucaugugu      120

agcucagugg agaguggccu gccuggucgc gauggacggg augggagaga gggcccucgg      180

ggcgagaagg gggacccagg uuugccagga gcugcagggc aagcagggau gccuggacaa      240

gcuggcccag uugggcccaa aggggacaau ggcucuguug gagaaccugg accaaaggga      300

gacacugggc caaguggacc uccaggaccu cccggugugc cugguccagc uggaagagaa      360

gguccccugg ggaagcaggg gaacauagga ccucagggca agccaggccc aaaaggagaa      420

gcugggccca aaggagaagu aggugcccca ggcaugcagg gcucggcagg ggcaagaggc      480

cucgcaggcc cuaagggaga gcgagguguc ccuggugagc guggaguccc uggaaacaca      540

ggggcagcag ggucugcugg agccaugggu ccccagggaa guccaggugc caggggaccc      600

ccgggauuga agggggacaa aggcauuccu ggagacaaag gagcaaaggg agaaaguggg      660

cuuccagaug uugcuucucu gaggcagcag guugaggccu uacagggaca aguacagcac      720

cuccaggcug cuuucucuca guauaagaaa guugagcucu ucccaaaugg ccaaaguguc      780

ggggagaaga uuuucaagac agcaggcuuu guaaaaccau uuacggaggc acagcugcug      840

ugcacacagg cugguggaca guuggccucu ccacgcucug ccgcugagaa ugccgccuug      900

caacagcugg ucguagcuaa gaacgaggcu gcuuuccuga gcaugacuga uuccaagaca      960

gagggcaagu ucaccuaccc cacaggagag ucccuggucu auuccaacug ggccccaggg     1020

gagcccaacg augauggcgg gucagaggac uguguggaga ucuucaccaa uggcaagugg     1080

aaugacaggg cuuguggaga aaagcgucuu guggucugcg aguucuga                  1128


<210>  9384
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9384
augcuccucu uccugcugag cgcccucgug cugcugaccc agccccucgg cuaccuggag       60

gccgagauga agaccuacuc ccaccgcacg augccgagcg cgugcacccu ggucaugugc      120

uccagcgugg aguccgggcu ccccggccgg gacgggcgcg acggccggga ggggccccgc      180

ggcgagaagg gcgaccccgg gcugccgggc gccgccgggc aggccggcau gcccgggcag      240

gccggccccg ugggccccaa gggggacaac ggcagcgucg gggagccggg ccccaagggc      300

gacaccgggc ccuccgggcc cccggggccg cccggcgugc ccgggcccgc gggccgggag      360

ggcccccugg ggaagcaggg caacaucggg ccccagggca agcccgggcc gaagggcgag      420

gccggcccca agggggaggu gggcgccccc gggaugcagg gcagcgccgg ggcgcgcggc      480

cucgccggcc ccaaggggga gcggggcguc ccgggggagc gcggcgugcc cggcaacacc      540

ggggccgccg gcuccgccgg ggcgaugggc ccccagggga gccccggcgc ccggggcccg      600

cccgggcuga agggcgacaa ggggaucccc ggcgacaagg gggccaaggg cgaguccggc      660

cugccggacg uggccagccu ccgccagcag gucgaggccc ugcagggcca ggugcagcac      720

cuccaggcgg ccuucuccca guacaagaag guggagcugu uccccaacgg ccagagcguc      780

ggggagaaga ucuucaagac ggccggcuuc gugaagcccu ucaccgaggc ccagcugcug      840

ugcacccagg ccgggggcca gcuggcgagc ccccgguccg ccgccgagaa cgccgcccug      900

cagcagcugg uggucgcgaa gaacgaggcc gccuuccucu ccaugaccga cagcaagacg      960

gagggcaagu ucaccuaccc gaccggggag ucccuggugu acagcaacug ggcccccggc     1020

gagcccaacg acgacggggg cagcgaggac ugcguggaga ucuucaccaa cgggaagugg     1080

aacgaccgcg cgugcggcga gaagcggcug gucgugugcg aguucuga                  1128


<210>  9385
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9385
augcuccucu uccuccucuc cgcccucguc cuccucaccc agccccucgg cuaccucgag       60

gccgagauga agaccuacuc ccaccgcacc augcccuccg ccugcacccu cgucaugugc      120

uccuccgucg aguccggccu ccccggccgc gacggccgcg acggccgcga gggcccccgc      180

ggcgagaagg gcgaccccgg ccuccccggc gccgccggcc aggccggcau gcccggccag      240

gccggccccg ucggccccaa gggcgacaac ggcuccgucg gcgagcccgg ccccaagggc      300

gacaccggcc ccuccggccc ccccggcccc cccggcgucc ccggccccgc cggccgcgag      360

ggcccccucg gcaagcaggg caacaucggc ccccagggca agcccggccc caagggcgag      420

gccggcccca agggcgaggu cggcgccccc ggcaugcagg gcuccgccgg cgcccgcggc      480

cucgccggcc ccaagggcga gcgcggcguc cccggcgagc gcggcguccc cggcaacacc      540

ggcgccgccg gcuccgccgg cgccaugggc ccccagggcu cccccggcgc ccgcggcccc      600

cccggccuca agggcgacaa gggcaucccc ggcgacaagg gcgccaaggg cgaguccggc      660

cuccccgacg ucgccucccu ccgccagcag gucgaggccc uccagggcca gguccagcac      720

cuccaggccg ccuucuccca guacaagaag gucgagcucu uccccaacgg ccaguccguc      780

ggcgagaaga ucuucaagac cgccggcuuc gucaagcccu ucaccgaggc ccagcuccuc      840

ugcacccagg ccggcggcca gcucgccucc ccccgcuccg ccgccgagaa cgccgcccuc      900

cagcagcucg ucgucgccaa gaacgaggcc gccuuccucu ccaugaccga cuccaagacc      960

gagggcaagu ucaccuaccc caccggcgag ucccucgucu acuccaacug ggcccccggc     1020

gagcccaacg acgacggcgg cuccgaggac ugcgucgaga ucuucaccaa cggcaagugg     1080

aacgaccgcg ccugcggcga gaagcgccuc gucgucugcg aguucuga                  1128


<210>  9386
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9386
augcuccugu uccuucugag cgccuuggug uuacugaccc agccccuagg cuaccucgag       60

gcugaaauga agacauauuc ccacagaacu augccuucug caugcacgcu ggucaugugu      120

ucaaguguug agagcgggcu uccaggaagg gacggucggg auggccgcga agggccgcga      180

ggagagaaag gcgaccccgg ucugccuggg gccgcgggac aagcuggcau gccaggccag      240

gccgggcccg ugggaccuaa gggugauaac ggcuccguag gggaaccagg acccaaaggc      300

gacaccgguc cuucugggcc accgggaccc ccuggcgugc caggccccgc agggcgugag      360

ggaccuuugg guaagcaggg caauaucggg ccacagggaa aacccggccc gaagggugag      420

gccgggccua agggcgaagu cggagcuccc ggcaugcaag ggucggcagg agccagaggu      480

cucgcuggcc caaaagggga gaggggagug ccuggcgaac gggguguucc cgggaacaca      540

ggcgccgcgg gaucagcagg cgccaugggg ccacagggaa gccccggugc ucgcggcccu      600

ccagggcuga agggagauaa aggcauuccg ggugacaagg gggccaaagg cgagagugga      660

cugcccgaug uggcaucccu cagacagcag gucgaggcuu uacaaggcca ggugcagcau      720

cugcaggccg cguuuucuca auacaagaag guagaacuuu ucccuaaugg gcagagcguu      780

ggagagaaaa uauuuaagac ugccggcuuc gugaaaccau uuaccgaagc acaguugcug      840

ugcacacaag cuggugggca gcuagccucc cccaggucag cugccgagaa cgcagcccuc      900

cagcagcugg ucguggcuaa gaaugaagcg gcauuccuua guaugaccga cagcaaaacu      960

gagggaaagu uuacauaucc uaccggcgag ucucuggugu acuccaacug ggccccaggu     1020

gaacccaaug augacggcgg gucagaggau ugugucgaaa ucuucacgaa cggaaaaugg     1080

aaugaccggg cuugcggcga gaagcgcuug guugugugug aauuuuga                  1128


<210>  9387
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9387
augcugcugu uccugcugag cgcccuggug cugcugaccc agccccuggg cuaccuggag       60

gccgagauga agaccuacag ccacagaacc augcccagcg ccugcacccu ggugaugugc      120

agcagcgugg agagcggccu gcccggcaga gacggcagag acggcagaga gggccccaga      180

ggcgagaagg gcgaccccgg ccugcccggc gccgccggcc aggccggcau gcccggccag      240

gccggccccg ugggccccaa gggcgacaac ggcagcgugg gcgagcccgg ccccaagggc      300

gacaccggcc ccagcggccc ccccggcccc cccggcgugc ccggccccgc cggcagagag      360

ggcccccugg gcaagcaggg caacaucggc ccccagggca agcccggccc caagggcgag      420

gccggcccca agggcgaggu gggcgccccc ggcaugcagg gcagcgccgg cgccagaggc      480

cuggccggcc ccaagggcga gagaggcgug cccggcgaga gaggcgugcc cggcaacacc      540

ggcgccgccg gcagcgccgg cgccaugggc ccccagggca gccccggcgc cagaggcccc      600

cccggccuga agggcgacaa gggcaucccc ggcgacaagg gcgccaaggg cgagagcggc      660

cugcccgacg uggccagccu gagacagcag guggaggccc ugcagggcca ggugcagcac      720

cugcaggccg ccuucagcca guacaagaag guggagcugu uccccaacgg ccagagcgug      780

ggcgagaaga ucuucaagac cgccggcuuc gugaagcccu ucaccgaggc ccagcugcug      840

ugcacccagg ccggcggcca gcuggccagc cccagaagcg ccgccgagaa cgccgcccug      900

cagcagcugg ugguggccaa gaacgaggcc gccuuccuga gcaugaccga cagcaagacc      960

gagggcaagu ucaccuaccc caccggcgag agccuggugu acagcaacug ggcccccggc     1020

gagcccaacg acgacggcgg cagcgaggac ugcguggaga ucuucaccaa cggcaagugg     1080

aacgacagag ccugcggcga gaagagacug guggugugcg aguucuga                  1128


<210>  9388
<211>  1128
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Surfactant_protein_D__Homo_sapiens__CCDS7362.1

<400>  9388
augcuccugu uccugcuuag cgcccuggug cuccugaccc agccccuugg cuaccuggag       60

gcugaaauga agacauauuc ccacagaacg augccuucug ccugcacccu cgucaugugu      120

agcuccguug agucugggcu gccgggacgg gacggccgcg augggagaga aggaccccgg      180

ggcgagaaag gggacccugg acugcccggc gcggcuggcc aagccgggau gccuggacag      240

gccggccccg uggggccuaa gggagauaac ggcagcgugg gggaaccggg acccaaaggc      300

gacacaggcc cuuccgggcc cccuggaccc ccgggcgucc cugggcccgc uggacgcgag      360

ggcccucucg ggaagcaggg aaauaucggc ccccagggca aacccgggcc uaagggagag      420

gccggcccga agggggaagu gggagcuccc ggcaugcaag ggucugccgg cgcgagagga      480

cuggccggcc cuaaagggga gcggggaguu cccggcgaac gcggggugcc uggaaacacc      540

ggcgcugccg ggagcgcugg cgccauggga ccccagggcu ccccgggggc gagaggaccu      600

cccggccuua agggggauaa agggauuccu ggcgacaagg gggccaaagg cgagagcgga      660

cugcccgaug ucgcuucucu ccggcaacag guggaggccc ugcagggcca gguucagcau      720

cuucaggcug ccuuuuccca auacaagaag guggaacugu ucccuaaugg gcagagcguc      780

ggagagaaaa ucuuuaagac agccggcuuc gugaaacccu uuaccgaagc ucagcuccug      840

ugcacacaag cgggaggaca gcuggccucu ccgcgcuccg cugccgagaa cgccgcucuc      900

cagcagcugg uggucgccaa gaaugaagcg gcuuuccuua gcaugaccga cucuaaaacg      960

gagggcaagu uuaccuaucc uacaggggag ucccugguuu acagcaacug ggcccccggc     1020

gaacccaaug augacggagg cuccgaggau uguguggaaa uuuucaccaa cgggaaaugg     1080

aaugacagag ccugcggaga gaagcggcuc guggucugug aauuuuga                  1128


<210>  9389
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TAK1__Homo_sapiens__O43318

<400>  9389

Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly 
1               5                   10                  15      


Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp 
            20                  25                  30          


Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly 
        35                  40                  45              


Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln 
    50                  55                  60                  


Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln 
65                  70                  75                  80  


Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys 
                85                  90                  95      


Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu 
            100                 105                 110         


Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala 
        115                 120                 125             


His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu 
    130                 135                 140                 


His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro 
145                 150                 155                 160 


Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe 
                165                 170                 175     


Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser 
            180                 185                 190         


Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu 
        195                 200                 205             


Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr 
    210                 215                 220                 


Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met 
225                 230                 235                 240 


Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro 
                245                 250                 255     


Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser 
            260                 265                 270         


Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met 
        275                 280                 285             


Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr 
    290                 295                 300                 


Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met 
305                 310                 315                 320 


Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu 
                325                 330                 335     


Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu 
            340                 345                 350         


Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu 
        355                 360                 365             


Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu 
    370                 375                 380                 


Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Ala Thr Thr Ala Tyr Ser Lys Pro Lys Arg Gly His Arg Lys Thr Ala 
                405                 410                 415     


Ser Phe Gly Asn Ile Leu Asp Val Pro Glu Ile Val Ile Ser Gly Asn 
            420                 425                 430         


Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu Thr Val Thr Gly Thr 
        435                 440                 445             


Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser Pro Ser Val Arg Met 
    450                 455                 460                 


Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro Thr Arg Ser His Pro 
465                 470                 475                 480 


Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly Ser Asp Asn Ser Ile 
                485                 490                 495     


Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu Gln Pro Leu Ala Pro 
            500                 505                 510         


Cys Pro Asn Ser Lys Glu Ser Met Ala Val Phe Glu Gln His Cys Lys 
        515                 520                 525             


Met Ala Gln Glu Tyr Met Lys Val Gln Thr Glu Ile Ala Leu Leu Leu 
    530                 535                 540                 


Gln Arg Lys Gln Glu Leu Val Ala Glu Leu Asp Gln Asp Glu Lys Asp 
545                 550                 555                 560 


Gln Gln Asn Thr Ser Arg Leu Val Gln Glu His Lys Lys Leu Leu Asp 
                565                 570                 575     


Glu Asn Lys Ser Leu Ser Thr Tyr Tyr Gln Gln Cys Lys Lys Gln Leu 
            580                 585                 590         


Glu Val Ile Arg Ser Gln Gln Gln Lys Arg Gln Gly Thr Ser 
        595                 600                 605     


<210>  9390
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TAK1__Homo_sapiens__ABC40734

<400>  9390
augucuacag ccucugccgc cuccuccucc uccucgucuu cggccgguga gaugaucgaa       60

gccccuuccc agguccucaa cuuugaagag aucgacuaca aggagaucga gguggaagag      120

guuguuggaa gaggagccuu uggaguuguu ugcaaagcua aguggagagc aaaagauguu      180

gcuauuaaac aaauagaaag ugaaucugag aggaaagcgu uuauuguaga gcuucggcag      240

uuaucccgug ugaaccaucc uaauauugua aagcuuuaug gagccugcuu gaauccagug      300

ugucuuguga uggaauaugc ugaagggggc ucuuuauaua augugcugca uggugcugaa      360

ccauugccau auuauacugc ugcccacgca augaguuggu guuuacagug uucccaagga      420

guggcuuauc uucacagcau gcaacccaaa gcgcuaauuc acagggaccu gaaaccacca      480

aacuuacugc ugguugcagg ggggacaguu cuaaaaauuu gugauuuugg uacagccugu      540

gacauucaga cacacaugac caauaacaag gggagugcug cuuggauggc accugaaguu      600

uuugaaggua guaauuacag ugaaaaaugu gacgucuuca gcugggguau uauucuuugg      660

gaagugauaa cgcgucggaa acccuuugau gagauuggug gcccagcuuu ccgaaucaug      720

ugggcuguuc auaaugguac ucgaccacca cugauaaaaa auuuaccuaa gcccauugag      780

agccugauga cucguuguug gucuaaagau ccuucccagc gcccuucaau ggaggaaauu      840

gugaaaauaa ugacucacuu gaugcgguac uuuccaggag cagaugagcc auuacaguau      900

ccuugucagu auucagauga aggacagagc aacucugcca ccaguacagg cucauucaug      960

gacauugcuu cuacaaauac gaguaacaaa agugacacua auauggagca aguuccugcc     1020

acaaaugaua cuauuaagcg cuuagaauca aaauuguuga aaaaucaggc aaagcaacag     1080

agugaaucug gacguuuaag cuugggagcc ucccguggga gcagugugga gagcuugccc     1140

ccaaccucug agggcaagag gaugagugcu gacaugucug aaauagaagc uaggaucgcc     1200

gcaaccacag ccuauuccaa gccuaaacgg ggccaccgua aaacugcuuc auuuggcaac     1260

auucuggaug ucccugagau cgucauauca ggcaacggac agccaagacg uagauccauc     1320

caagacuuga cuguaacugg aacagaaccu ggucagguga gcaguagguc auccaguccc     1380

agugucagaa ugauuacuac cucaggacca accucagaaa agccaacucg aagucaucca     1440

uggaccccug augauuccac agauaccaau ggaucagaua acuccauccc aauggcuuau     1500

cuuacacugg aucaccaacu acagccucua gcaccgugcc caaacuccaa agaaucuaug     1560

gcaguguuug aacagcauug uaaaauggca caagaauaua ugaaaguuca aacagaaauu     1620

gcauuguuau uacagagaaa gcaagaacua guugcagaac uggaccagga ugaaaaggac     1680

cagcaaaaua caucucgccu gguacaggaa cauaaaaagc uuuuagauga aaacaaaagc     1740

cuuucuacuu acuaccagca augcaaaaaa caacuagagg ucaucagaag ucagcagcag     1800

aaacgacaag gcacuucaug a                                               1821


<210>  9391
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TAK1__Homo_sapiens__ABC40734

<400>  9391
augagcaccg ccuccgccgc gagcuccagc uccagcucca gcgccggcga gaugaucgag       60

gcccccuccc aggugcugaa cuucgaggag aucgacuaca aggagaucga ggucgaggag      120

gugguggggc gcggcgccuu cggggucgug ugcaaggcca aguggcgggc gaaggacgug      180

gccaucaagc agaucgagag cgaguccgag cgcaaggccu ucaucgucga gcuccggcag      240

cugagccgcg ugaaccaccc gaacaucgug aagcuguacg gcgccugccu caaccccguc      300

ugccugguga uggaguacgc ggagggcggg ucccuguaca acgugcucca cggcgccgag      360

ccccugcccu acuacaccgc cgcccacgcc augagcuggu gccugcagug cucccagggg      420

gucgcguacc uccacagcau gcagccgaag gcccugaucc accgggaccu gaagccgccc      480

aaccuccugc ugguggccgg cgggacggug cucaagaucu gcgacuucgg caccgccugc      540

gacauccaga cccacaugac caacaacaag ggguccgccg cguggauggc ccccgagguc      600

uucgagggca gcaacuacuc cgagaagugc gacguguuca gcuggggcau cauccugugg      660

gaggugauca cgcgccggaa gcccuucgac gagaucgggg gccccgccuu ccgcaucaug      720

ugggccgucc acaacgggac ccggccgccc cugaucaaga accuccccaa gcccaucgag      780

agccugauga cccgcugcug guccaaggac cccagccagc ggcccuccau ggaggagauc      840

gugaagauca ugacccaccu gaugcgcuac uucccgggcg ccgacgagcc ccuccaguac      900

cccugccagu acagcgacga gggccagucc aacagcgcga cguccaccgg gagcuucaug      960

gacaucgccu ccaccaacac cagcaacaag uccgacacga acauggagca gguccccgcc     1020

accaacgaca ccaucaagcg gcuggagagc aagcugcuca agaaccaggc caagcagcag     1080

uccgagagcg gccgccuguc ccugggggcc agccggggcu ccagcgugga gucccucccg     1140

cccaccagcg aggggaagcg caugagcgcg gacauguccg agaucgaggc ccggaucgcc     1200

gccacgaccg cguacagcaa gcccaagcgc ggccaccgga agaccgccuc cuucggcaac     1260

auccuggacg ugcccgagau cgugaucagc gggaacggcc agccgcgccg gcgcuccauc     1320

caggaccuga ccgucacggg gaccgagccc ggccagguga gcucccgcag cuccagcccc     1380

uccguccgga ugaucaccac cagcgggccc acguccgaga agccgacccg cagccacccc     1440

uggacccccg acgacuccac cgacacgaac ggcagcgaca acuccauccc gauggccuac     1500

cucacccugg accaccagcu gcagccccuc gcccccugcc ccaacagcaa ggagagcaug     1560

gccguguucg agcagcacug caagauggcg caggaguaca ugaaggugca gaccgagauc     1620

gcccugcugc uccagcggaa gcaggagcug gucgccgagc uggaccagga cgagaaggac     1680

cagcagaaca ccucccgccu cgugcaggag cacaagaagc ugcuggacga gaacaagagc     1740

cucuccacgu acuaccagca gugcaagaag cagcuggagg ugauccggag ccagcagcag     1800

aagcgccagg gcaccuccug a                                               1821


<210>  9392
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TAK1__Homo_sapiens__ABC40734

<400>  9392
auguccaccg ccuccgccgc cuccuccucc uccuccuccu ccgccggcga gaugaucgag       60

gcccccuccc agguccucaa cuucgaggag aucgacuaca aggagaucga ggucgaggag      120

gucgucggcc gcggcgccuu cggcgucguc ugcaaggcca aguggcgcgc caaggacguc      180

gccaucaagc agaucgaguc cgaguccgag cgcaaggccu ucaucgucga gcuccgccag      240

cucucccgcg ucaaccaccc caacaucguc aagcucuacg gcgccugccu caaccccguc      300

ugccucguca uggaguacgc cgagggcggc ucccucuaca acguccucca cggcgccgag      360

ccccuccccu acuacaccgc cgcccacgcc auguccuggu gccuccagug cucccagggc      420

gucgccuacc uccacuccau gcagcccaag gcccucaucc accgcgaccu caagcccccc      480

aaccuccucc ucgucgccgg cggcaccguc cucaagaucu gcgacuucgg caccgccugc      540

gacauccaga cccacaugac caacaacaag ggcuccgccg ccuggauggc ccccgagguc      600

uucgagggcu ccaacuacuc cgagaagugc gacgucuucu ccuggggcau cauccucugg      660

gaggucauca cccgccgcaa gcccuucgac gagaucggcg gccccgccuu ccgcaucaug      720

ugggccgucc acaacggcac ccgccccccc cucaucaaga accuccccaa gcccaucgag      780

ucccucauga cccgcugcug guccaaggac cccucccagc gccccuccau ggaggagauc      840

gucaagauca ugacccaccu caugcgcuac uuccccggcg ccgacgagcc ccuccaguac      900

cccugccagu acuccgacga gggccagucc aacuccgcca ccuccaccgg cuccuucaug      960

gacaucgccu ccaccaacac cuccaacaag uccgacacca acauggagca gguccccgcc     1020

accaacgaca ccaucaagcg ccucgagucc aagcuccuca agaaccaggc caagcagcag     1080

uccgaguccg gccgccucuc ccucggcgcc ucccgcggcu ccuccgucga gucccucccc     1140

cccaccuccg agggcaagcg cauguccgcc gacauguccg agaucgaggc ccgcaucgcc     1200

gccaccaccg ccuacuccaa gcccaagcgc ggccaccgca agaccgccuc cuucggcaac     1260

auccucgacg uccccgagau cgucaucucc ggcaacggcc agccccgccg ccgcuccauc     1320

caggaccuca ccgucaccgg caccgagccc ggccaggucu ccucccgcuc cuccuccccc     1380

uccguccgca ugaucaccac cuccggcccc accuccgaga agcccacccg cucccacccc     1440

uggacccccg acgacuccac cgacaccaac ggcuccgaca acuccauccc cauggccuac     1500

cucacccucg accaccagcu ccagccccuc gcccccugcc ccaacuccaa ggaguccaug     1560

gccgucuucg agcagcacug caagauggcc caggaguaca ugaaggucca gaccgagauc     1620

gcccuccucc uccagcgcaa gcaggagcuc gucgccgagc ucgaccagga cgagaaggac     1680

cagcagaaca ccucccgccu cguccaggag cacaagaagc uccucgacga gaacaagucc     1740

cucuccaccu acuaccagca gugcaagaag cagcucgagg ucauccgcuc ccagcagcag     1800

aagcgccagg gcaccuccug a                                               1821


<210>  9393
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TAK1__Homo_sapiens__ABC40734

<400>  9393
augagcaccg ccuccgcugc aucuucaagu agcuccucuu cggccggcga gaugaucgaa       60

gcgcccucac aggugcugaa cuucgaggaa auugacuaca aggagauaga agucgaggag      120

guugugggga gaggagcuuu ugguguagug ugcaaagcca aguggagggc aaaagauguc      180

gccaucaagc aaauugaaag cgagagugaa cggaaggcuu ucaucgugga gcuccgccag      240

cuuucccgag uuaaucaccc uaacauugug aaacuguaug gcgcauguuu gaauccaguc      300

ugcuuaguga uggaguacgc cgaaggggga ucucuguaua acguacuaca uggcgcugag      360

ccgcuccccu acuauacagc cgcgcacgca augagcuggu gucugcagug cucccagggu      420

guugccuacc uucauucaau gcaaccuaag gcucugaucc accgugacuu gaaaccaccc      480

aaucuccugc ugguggccgg gggaacuguc cucaagauau gugauuuugg cacggcaugc      540

gacauccaga cccauaugac aaacaauaaa ggcagugcug ccuggauggc gccugaagug      600

uucgagggga gcaacuauuc ugaaaagugu gauguguuuu ccuggggaau uaucuuaugg      660

gaggucauua cuagaaggaa accauucgac gagaucggug gccccgccuu ucggauaaug      720

ugggcaguuc acaaugggac ccgcccucca cugauuaaga accuuccgaa gcccaucgaa      780

ucauugauga caagaugcug gagcaaagau ccuagucaga ggccaucuau ggaggaaauu      840

gugaagauca ugacccaccu gaugcgguac uuccccggag cugacgagcc ucuacaguac      900

ccaugucaau auuccgauga aggccagagc aauucggcca cuucuacagg uuccuuuaug      960

gacaucgcuu caaccaacac gaguaauaaa agcgauacua acauggagca gguacccgcc     1020

accaaugaca caauuaagcg ccucgagucc aaacugcuua agaaccaggc aaaacaacag     1080

ucugaaagcg ggcgacuguc auugggagcc aguagaggcu ccagcgugga gucucucccg     1140

ccuacuucag aaggcaagag gaugagugcu gauaugagcg agauagaagc gcggaucgca     1200

gccaccacag cuuacuccaa gcccaaacgu gggcaucgca agaccgccuc uuucggaaac     1260

auucuggacg ucccagagau cgugauaucg gguaauggcc agccuagaag gcggagcauu     1320

caagacuuaa cgguuacugg gacagagccc ggacaggugu ccucacgaag uucuagccca     1380

uccguccgca ugaucaccac uucaggcccc acaagcgaaa aaccuaccag aucucaccca     1440

uggacgccgg augacuccac cgauacaaac gguagugaca auagcauccc cauggcauau     1500

cugacucucg aucaucagcu ucagccucug gccccaugcc ccaacucuaa ggaguccaug     1560

gcuguguuug aacaacacug uaaaauggcc caggaguaca ugaagguaca gaccgagauu     1620

gcauugcuac ugcagaggaa gcaagaacuc guugcggagc uggaccagga ugaaaaagac     1680

cagcagaaua caucacggcu ugugcaagag cacaagaaac uguuggauga aaacaagagu     1740

cucagcacuu auuaccagca gugcaaaaag cagcuggagg ucauccgcuc gcaacagcag     1800

aagagacaag ggaccuccug a                                               1821


<210>  9394
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TAK1__Homo_sapiens__ABC40734

<400>  9394
augagcaccg ccagcgccgc cagcagcagc agcagcagca gcgccggcga gaugaucgag       60

gcccccagcc aggugcugaa cuucgaggag aucgacuaca aggagaucga gguggaggag      120

guggugggca gaggcgccuu cggcguggug ugcaaggcca aguggagagc caaggacgug      180

gccaucaagc agaucgagag cgagagcgag agaaaggccu ucaucgugga gcugagacag      240

cugagcagag ugaaccaccc caacaucgug aagcuguacg gcgccugccu gaaccccgug      300

ugccugguga uggaguacgc cgagggcggc agccuguaca acgugcugca cggcgccgag      360

ccccugcccu acuacaccgc cgcccacgcc augagcuggu gccugcagug cagccagggc      420

guggccuacc ugcacagcau gcagcccaag gcccugaucc acagagaccu gaagcccccc      480

aaccugcugc ugguggccgg cggcaccgug cugaagaucu gcgacuucgg caccgccugc      540

gacauccaga cccacaugac caacaacaag ggcagcgccg ccuggauggc ccccgaggug      600

uucgagggca gcaacuacag cgagaagugc gacguguuca gcuggggcau cauccugugg      660

gaggugauca ccagaagaaa gcccuucgac gagaucggcg gccccgccuu cagaaucaug      720

ugggccgugc acaacggcac cagacccccc cugaucaaga accugcccaa gcccaucgag      780

agccugauga ccagaugcug gagcaaggac cccagccaga gacccagcau ggaggagauc      840

gugaagauca ugacccaccu gaugagauac uuccccggcg ccgacgagcc ccugcaguac      900

cccugccagu acagcgacga gggccagagc aacagcgcca ccagcaccgg cagcuucaug      960

gacaucgcca gcaccaacac cagcaacaag agcgacacca acauggagca ggugcccgcc     1020

accaacgaca ccaucaagag acuggagagc aagcugcuga agaaccaggc caagcagcag     1080

agcgagagcg gcagacugag ccugggcgcc agcagaggca gcagcgugga gagccugccc     1140

cccaccagcg agggcaagag aaugagcgcc gacaugagcg agaucgaggc cagaaucgcc     1200

gccaccaccg ccuacagcaa gcccaagaga ggccacagaa agaccgccag cuucggcaac     1260

auccuggacg ugcccgagau cgugaucagc ggcaacggcc agcccagaag aagaagcauc     1320

caggaccuga ccgugaccgg caccgagccc ggccagguga gcagcagaag cagcagcccc     1380

agcgugagaa ugaucaccac cagcggcccc accagcgaga agcccaccag aagccacccc     1440

uggacccccg acgacagcac cgacaccaac ggcagcgaca acagcauccc cauggccuac     1500

cugacccugg accaccagcu gcagccccug gcccccugcc ccaacagcaa ggagagcaug     1560

gccguguucg agcagcacug caagauggcc caggaguaca ugaaggugca gaccgagauc     1620

gcccugcugc ugcagagaaa gcaggagcug guggccgagc uggaccagga cgagaaggac     1680

cagcagaaca ccagcagacu ggugcaggag cacaagaagc ugcuggacga gaacaagagc     1740

cugagcaccu acuaccagca gugcaagaag cagcuggagg ugaucagaag ccagcagcag     1800

aagagacagg gcaccagcug a                                               1821


<210>  9395
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TAK1__Homo_sapiens__ABC40734

<400>  9395
augagcaccg ccuccgcugc cucuagcucc ucuagcuccu cugcgggcga gaugaucgaa       60

gcucccagcc aggugcugaa cuucgaggaa auugacuaca aggagaucga agucgaggag      120

guugugggga gaggagccuu uggcgugguc ugcaaagcca aguggcgggc uaaagaugug      180

gccauuaagc aaaucgaauc cgagagcgaa cgcaaggcuu ucauuguuga gcucagacag      240

cugucucggg ugaaucaccc uaacaucguc aaacuuuaug gggccugucu gaauccggug      300

ugccucguua uggaguacgc ggaaggaggc ucccuguaua acgugcuuca uggggccgag      360

ccccugccuu acuauacagc ugcccacgcu augagcuggu gucuccagug cucucaggga      420

gucgccuacc ugcauuccau gcaacccaag gcgcugaucc accgcgaccu caaaccuccc      480

aaucugcuuc ugguggccgg cggcacggug cucaagauuu gugauuuugg gaccgcuugc      540

gacauccaga cacauaugac caacaauaaa ggaagcgccg cuuggauggc cccugaaguc      600

uucgagggcu cuaacuauuc cgaaaagugu gauguuuuua gcugggggau uauccugugg      660

gaggugauua caagacggaa accguucgac gagaucggag gccccgccuu ucgcauuaug      720

ugggcugugc acaaugggac cagaccuccc cuuaucaaga accugccuaa gcccaucgaa      780

ucccucauga cacggugcug gucuaaagau ccgagccagc gcccuuccau ggaggaaauu      840

gucaagauca ugacccaccu gaugagauac uuccccggag cggacgagcc ucugcaguac      900

cccugucaau auagcgauga aggccagucu aauuccgcca cgagcaccgg cucuuuuaug      960

gacauugcua gcacaaacac cuccaauaaa ucugauacaa acauggaaca ggugcccgcc     1020

accaaugaca cgaucaagcg gcucgagagc aaacugcuua agaaccaggc caaacaacag     1080

uccgagagcg ggcgccuguc ucucggagcu uccagaggca gcucuguuga gucccugccu     1140

ccgacaagcg aagggaagcg gauguccgcc gauaugucug agauugaagc gcgcaucgcu     1200

gccaccacag ccuacagcaa gcccaaaaga ggacaucgga agaccgcuuc cuucggcaac     1260

auccuugacg ugccugagau ugucaucucu gggaauggac agcccagacg ccggagcauu     1320

caagaccuga ccgugacagg cacggagccu ggccagguuu ccagcagauc uuccagcccc     1380

ucugugcgca ugaucaccac auccgggccg accagcgaaa aaccuacacg gucucacccc     1440

uggaccccug augacagcac ggauacaaac ggauccgaca auagcauucc cauggccuau     1500

cucacccugg aucaucagcu gcagccucuc gcucccugcc cgaacucuaa ggaguccaug     1560

gccgucuuug aacaacacug uaaaauggcg caggaguaca ugaaggugca gaccgagauc     1620

gcccugcuuc ugcagagaaa gcaagaacuc gucgcugagc uggaccagga ugaaaaagac     1680

cagcagaaua caagccgccu ugugcaagag cacaagaaac ugcucgauga aaacaagucc     1740

cugucuaccu auuaccagca gugcaaaaag cagcuggagg uuauccggag ccaacagcag     1800

aagagacaag gcacauccug a                                               1821


<210>  9396
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TAK1__Homo_sapiens__P49116

<400>  9396

Met Thr Ser Pro Ser Pro Arg Ile Gln Ile Ile Ser Thr Asp Ser Ala 
1               5                   10                  15      


Val Ala Ser Pro Gln Arg Ile Gln Ile Val Thr Asp Gln Gln Thr Gly 
            20                  25                  30          


Gln Lys Ile Gln Ile Val Thr Ala Val Asp Ala Ser Gly Ser Pro Lys 
        35                  40                  45              


Gln Gln Phe Ile Leu Thr Ser Pro Asp Gly Ala Gly Thr Gly Lys Val 
    50                  55                  60                  


Ile Leu Ala Ser Pro Glu Thr Ser Ser Ala Lys Gln Leu Ile Phe Thr 
65                  70                  75                  80  


Thr Ser Asp Asn Leu Val Pro Gly Arg Ile Gln Ile Val Thr Asp Ser 
                85                  90                  95      


Ala Ser Val Glu Arg Leu Leu Gly Lys Thr Asp Val Gln Arg Pro Gln 
            100                 105                 110         


Val Val Glu Tyr Cys Val Val Cys Gly Asp Lys Ala Ser Gly Arg His 
        115                 120                 125             


Tyr Gly Ala Val Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Ser 
    130                 135                 140                 


Val Arg Lys Asn Leu Thr Tyr Ser Cys Arg Ser Asn Gln Asp Cys Ile 
145                 150                 155                 160 


Ile Asn Lys His His Arg Asn Arg Cys Gln Phe Cys Arg Leu Lys Lys 
                165                 170                 175     


Cys Leu Glu Met Gly Met Lys Met Glu Ser Val Gln Ser Glu Arg Lys 
            180                 185                 190         


Pro Phe Asp Val Gln Arg Glu Lys Pro Ser Asn Cys Ala Ala Ser Thr 
        195                 200                 205             


Glu Lys Ile Tyr Ile Arg Lys Asp Leu Arg Ser Pro Leu Ile Ala Thr 
    210                 215                 220                 


Pro Thr Phe Val Ala Asp Lys Asp Gly Ala Arg Gln Thr Gly Leu Leu 
225                 230                 235                 240 


Asp Pro Gly Met Leu Val Asn Ile Gln Gln Pro Leu Ile Arg Glu Asp 
                245                 250                 255     


Gly Thr Val Leu Leu Ala Thr Asp Ser Lys Ala Glu Thr Ser Gln Gly 
            260                 265                 270         


Ala Leu Gly Thr Leu Ala Asn Val Val Thr Ser Leu Ala Asn Leu Ser 
        275                 280                 285             


Glu Ser Leu Asn Asn Gly Asp Thr Ser Glu Ile Gln Pro Glu Asp Gln 
    290                 295                 300                 


Ser Ala Ser Glu Ile Thr Arg Ala Phe Asp Thr Leu Ala Lys Ala Leu 
305                 310                 315                 320 


Asn Thr Thr Asp Ser Ser Ser Ser Pro Ser Leu Ala Asp Gly Ile Asp 
                325                 330                 335     


Thr Ser Gly Gly Gly Ser Ile His Val Ile Ser Arg Asp Gln Ser Thr 
            340                 345                 350         


Pro Ile Ile Glu Val Glu Gly Pro Leu Leu Ser Asp Thr His Val Thr 
        355                 360                 365             


Phe Lys Leu Thr Met Pro Ser Pro Met Pro Glu Tyr Leu Asn Val His 
    370                 375                 380                 


Tyr Ile Cys Glu Ser Ala Ser Arg Leu Leu Phe Leu Ser Met His Trp 
385                 390                 395                 400 


Ala Arg Ser Ile Pro Ala Phe Gln Ala Leu Gly Gln Asp Cys Asn Thr 
                405                 410                 415     


Ser Leu Val Arg Ala Cys Trp Asn Glu Leu Phe Thr Leu Gly Leu Ala 
            420                 425                 430         


Gln Cys Ala Gln Val Met Ser Leu Ser Thr Ile Leu Ala Ala Ile Val 
        435                 440                 445             


Asn His Leu Gln Asn Ser Ile Gln Glu Asp Lys Leu Ser Gly Asp Arg 
    450                 455                 460                 


Ile Lys Gln Val Met Glu His Ile Trp Lys Leu Gln Glu Phe Cys Asn 
465                 470                 475                 480 


Ser Met Ala Lys Leu Asp Ile Asp Gly Tyr Glu Tyr Ala Tyr Leu Lys 
                485                 490                 495     


Ala Ile Val Leu Phe Ser Pro Asp His Pro Gly Leu Thr Ser Thr Ser 
            500                 505                 510         


Gln Ile Glu Lys Phe Gln Glu Lys Ala Gln Met Glu Leu Gln Asp Tyr 
        515                 520                 525             


Val Gln Lys Thr Tyr Ser Glu Asp Thr Tyr Arg Leu Ala Arg Ile Leu 
    530                 535                 540                 


Val Arg Leu Pro Ala Leu Arg Leu Met Ser Ser Asn Ile Thr Glu Glu 
545                 550                 555                 560 


Leu Phe Phe Thr Gly Leu Ile Gly Asn Val Ser Ile Asp Ser Ile Ile 
                565                 570                 575     


Pro Tyr Ile Leu Lys Met Glu Thr Ala Glu Tyr Asn Gly Gln Ile Thr 
            580                 585                 590         


Gly Ala Ser Leu 
        595     


<210>  9397
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TAK1__Homo_sapiens__AAC50118

<400>  9397
augaccagcc ccuccccacg cauccagaua aucuccaccg acucugcugu agccucaccu       60

cagcgcauuc agauugucac agaccagcag acaggacaga aaauccagau agucaccgca      120

guggacgccu ccggaucccc caaacagcag uucauccuga ccagcccaga uggagcugga      180

acugggaagg ugauccuggc uuccccagag acauccagcg ccaagcaacu cauauucacc      240

accucagaca accucguccc uggcaggauc cagauuguca cggauucugc cucuguggag      300

cguuuacugg ggaagacgga cguccagcgg ccccaggugg uagaguacug uguggucugu      360

ggcgacaaag ccuccggccg ucacuauggg gcugucaguu gugaagguug caaagguuuc      420

uucaaaagga gugugaggaa aaauuugacc uacagcugcc ggagcaacca agacugcauc      480

aucaauaaac aucaccggaa ccgcugucag uuuugccggc ugaaaaaaug cuuagagaug      540

ggcaugaaaa uggaaucugu gcagagugaa cggaagcccu ucgaugugca acgggagaaa      600

ccaagcaauu gugcugcuuc aacugagaaa aucuauaucc ggaaagaccu gagaaguccc      660

cugauagcua cucccacguu uguggcagac aaagauggag caagacaaac aggucuucuu      720

gauccaggga ugcuugugaa cauccagcag ccuuugauac gugaggaugg uacaguucuc      780

cuggccacgg auucuaaggc ugaaacaagc cagggagcuc ugggcacacu ggcaaaugua      840

gugaccuccc uugccaaccu aagugaaucu uugaacaacg gugacacuuc agaaauccag      900

ccagaggacc agucugcaag ugagauaacu cgggcauuug auaccuuagc uaaagcacuu      960

aauaccacag acagcuccuc uucuccaagc uuggcagaug ggauagacac caguggagga     1020

gggagcaucc acgucaucag cagagaccag ucgacaccca ucauugaggu ugaaggcccc     1080

cuccuuucag acacacacgu cacauuuaag cuaacaaugc ccaguccaau gccagaguac     1140

cucaacgugc acuacaucug ugagucugca ucccgucugc uuuuccucuc aaugcacugg     1200

gcucggucaa ucccagccuu ucaggcacuu gggcaggacu gcaacaccag ccuugugcgg     1260

gccugcugga augagcucuu cacccucggc cuggcccagu gugcccaggu caugagucuc     1320

uccaccaucc uggcugccau ugucaaccac cugcagaaca gcauccagga agauaaacuu     1380

ucuggugacc ggauaaagca agucauggag cacaucugga agcugcagga guucuguaac     1440

agcauggcga agcuggauau agauggcuau gaguaugcau accuuaaagc uauaguucuc     1500

uuuagccccg aucauccagg uuugaccagc acaagccaga uugaaaaauu ccaagaaaag     1560

gcacagaugg aguugcagga cuauguucag aaaaccuacu cagaagacac cuaccgauug     1620

gcccggaucc ucguucgccu gccggcacuc aggcugauga gcuccaacau aacagaagaa     1680

cuuuuuuuua cuggucucau uggcaauguu ucgauagaca gcauaauccc cuacauccuc     1740

aagauggaga cagcagagua uaauggccag aucaccggag ccagucuaua g              1791


<210>  9398
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TAK1__Homo_sapiens__AAC50118

<400>  9398
augaccagcc ccuccccgcg cauccagauc aucagcaccg acuccgccgu ggccagcccc       60

cagcggaucc agaucgucac ggaccagcag accggccaga agauccagau cgugaccgcg      120

guggacgccu ccgggagccc caagcagcag uucauccuga ccucccccga cggcgccggg      180

acgggcaagg ucauccucgc cagcccggag accuccagcg ccaagcagcu gaucuucacc      240

accuccgaca accuggugcc cgggcgcauc cagaucguga cggacagcgc guccgucgag      300

cggcuccugg gcaagaccga cgugcagcgc ccccaggugg ucgaguacug cguggugugc      360

ggcgacaagg ccagcgggcg gcacuacggc gccgucuccu gcgaggggug caagggcuuc      420

uucaagcgca gcgugcggaa gaaccugacc uacuccugcc gcagcaacca ggacugcauc      480

aucaacaagc accaccggaa ccgcugccag uucugccggc ucaagaagug ccuggagaug      540

gggaugaaga uggaguccgu gcagagcgag cgcaagcccu ucgacgucca gcgggagaag      600

ccgagcaacu gcgccgcguc caccgagaag aucuacaucc gcaaggaccu gcggagcccc      660

cucaucgcca cgcccaccuu cguggccgac aaggacggcg cccgccagac cggccugcug      720

gaccccggga ugcucgugaa cauccagcag ccgcugaucc gggaggacgg caccguccug      780

cucgccacgg acuccaaggc ggagaccagc cagggggccc ugggcacccu ggccaacgug      840

gugaccuccc ucgccaaccu gagcgagucc cugaacaacg gcgacacgag cgagauccag      900

cccgaggacc aguccgccag cgagaucacc cgcgcguucg acacccucgc caaggcccug      960

aacaccacgg acuccagcuc cagccccucc cuggccgacg ggaucgacac cagcggcggg     1020

ggcuccaucc acgucaucag ccgggaccag uccaccccca ucaucgaggu ggaggggccg     1080

cuccugagcg acacccacgu gacguucaag cugaccaugc ccagccccau gcccgaguac     1140

cucaacgucc acuacaucug cgaguccgcc agccgccugc uguuccucuc caugcacugg     1200

gcgcggagca ucccggccuu ccaggcccug ggccaggacu gcaacaccuc ccuggugcgc     1260

gccugcugga acgagcuguu cacccugggc cuggcccagu gcgcgcaggu caugagccuc     1320

uccacgaucc uggccgccau cgugaaccac cuccagaaca gcauccagga ggacaagcuc     1380

uccggggacc gcaucaagca ggucauggag cacaucugga agcugcagga guucugcaac     1440

agcauggcca agcuggacau cgacggcuac gaguacgcgu accucaaggc caucgugcug     1500

uucucccccg accaccccgg gcugaccagc accucccaga ucgagaaguu ccaggagaag     1560

gcccagaugg agcuccagga cuacgugcag aagaccuaca gcgaggacac guaccggcug     1620

gcccgcaucc uggugcggcu ccccgcccug cgccugaugu ccagcaacau caccgaggag     1680

cuguucuuca ccggccucau cgggaacguc uccaucgaca gcaucauccc guacauccug     1740

aagauggaga ccgcggagua caacggccag aucaccggcg ccagccugug a              1791


<210>  9399
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TAK1__Homo_sapiens__AAC50118

<400>  9399
augaccuccc ccuccccccg cauccagauc aucuccaccg acuccgccgu cgccuccccc       60

cagcgcaucc agaucgucac cgaccagcag accggccaga agauccagau cgucaccgcc      120

gucgacgccu ccggcucccc caagcagcag uucauccuca ccucccccga cggcgccggc      180

accggcaagg ucauccucgc cucccccgag accuccuccg ccaagcagcu caucuucacc      240

accuccgaca accucguccc cggccgcauc cagaucguca ccgacuccgc cuccgucgag      300

cgccuccucg gcaagaccga cguccagcgc ccccaggucg ucgaguacug cgucgucugc      360

ggcgacaagg ccuccggccg ccacuacggc gccgucuccu gcgagggcug caagggcuuc      420

uucaagcgcu ccguccgcaa gaaccucacc uacuccugcc gcuccaacca ggacugcauc      480

aucaacaagc accaccgcaa ccgcugccag uucugccgcc ucaagaagug ccucgagaug      540

ggcaugaaga uggaguccgu ccaguccgag cgcaagcccu ucgacgucca gcgcgagaag      600

cccuccaacu gcgccgccuc caccgagaag aucuacaucc gcaaggaccu ccgcuccccc      660

cucaucgcca cccccaccuu cgucgccgac aaggacggcg cccgccagac cggccuccuc      720

gaccccggca ugcucgucaa cauccagcag ccccucaucc gcgaggacgg caccguccuc      780

cucgccaccg acuccaaggc cgagaccucc cagggcgccc ucggcacccu cgccaacguc      840

gucaccuccc ucgccaaccu cuccgagucc cucaacaacg gcgacaccuc cgagauccag      900

cccgaggacc aguccgccuc cgagaucacc cgcgccuucg acacccucgc caaggcccuc      960

aacaccaccg acuccuccuc cucccccucc cucgccgacg gcaucgacac cuccggcggc     1020

ggcuccaucc acgucaucuc ccgcgaccag uccaccccca ucaucgaggu cgagggcccc     1080

cuccucuccg acacccacgu caccuucaag cucaccaugc ccucccccau gcccgaguac     1140

cucaacgucc acuacaucug cgaguccgcc ucccgccucc ucuuccucuc caugcacugg     1200

gcccgcucca uccccgccuu ccaggcccuc ggccaggacu gcaacaccuc ccucguccgc     1260

gccugcugga acgagcucuu cacccucggc cucgcccagu gcgcccaggu caugucccuc     1320

uccaccaucc ucgccgccau cgucaaccac cuccagaacu ccauccagga ggacaagcuc     1380

uccggcgacc gcaucaagca ggucauggag cacaucugga agcuccagga guucugcaac     1440

uccauggcca agcucgacau cgacggcuac gaguacgccu accucaaggc caucguccuc     1500

uucucccccg accaccccgg ccucaccucc accucccaga ucgagaaguu ccaggagaag     1560

gcccagaugg agcuccagga cuacguccag aagaccuacu ccgaggacac cuaccgccuc     1620

gcccgcaucc ucguccgccu ccccgcccuc cgccucaugu ccuccaacau caccgaggag     1680

cucuucuuca ccggccucau cggcaacguc uccaucgacu ccaucauccc cuacauccuc     1740

aagauggaga ccgccgagua caacggccag aucaccggcg ccucccucug a              1791


<210>  9400
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TAK1__Homo_sapiens__AAC50118

<400>  9400
augaccagcc ccuccccuag aauccagauu auaucuacag acucagccgu ggcuagucca       60

caaaggaucc agauugucac ugaucagcag acgggccaaa agauccagau uguuaccgca      120

guggacgcca gcgggucccc gaaacagcag uucauccuga caucucccga uggagcgggu      180

acuggcaagg uaauacucgc uucgccugag accucaagcg ccaaacaacu uaucuuuaca      240

accagugaca accuggugcc agggcggauu cagaucguca cugauuccgc aucuguggaa      300

cgcuuguuag gaaagacaga cguucagcga ccccaggugg ucgaguacug cgugguaugu      360

ggcgauaaag ccagcggucg ucacuauggg gcuguuuccu gcgaaggaug uaagggcuuc      420

uuuaagagau cagugaggaa aaaucugacc uacaguugcc ggagcaacca agacuguauu      480

aucaauaagc aucaccgcaa cagaugccag uucuguaggc uuaaaaagug ccucgagaug      540

ggcaugaaaa uggaaucugu ccaguccgag cggaagccuu uugaugugca acgcgagaag      600

ccaucaaauu gugcagccag cacggagaaa auauauauuc gaaaggaccu gagaaguccc      660

cuuaucgcua cuccuaccuu cguggccgau aaagacgggg cgaggcagac aggacuguug      720

gauccaggua ugcucgucaa cauucagcag ccgcugaucc gggaagacgg cacuguucug      780

cucgcaaccg acucuaaggc cgaaacaucc caaggggcuu uaggaacccu ggccaaugug      840

guaacgagcc uugcaaacuu gucggagucu cugaauaacg gcgauacuuc cgagauccag      900

cccgaagacc agucagcuag ugagauuaca cgugccuuug auacccuagc gaaagcccuc      960

aauacuacag acagcuccuc uagcccuuca cuggcagaug guauagacac caguggggga     1020

ggcuccaucc augugauuag ccgcgaucag ucuacgccaa ucauagaagu cgagggcccc     1080

cuucugucag acacccacgu gacauucaag uugacuaugc cuaguccaau gcccgaauac     1140

cucaacguuc auuauauuug cgagagcgcu uccagacugu uauuucuguc uaugcacugg     1200

gccaggucga ucccggcuuu ccaagcccuc gggcaggauu guaauaccag ccuugugcgg     1260

gcaugcugga acgagcuguu uacauuggga cuagcccagu gcgcucaggu caugucccug     1320

ucaacuaucc ucgcggcaau ugugaaucau cugcaaaaca guauccagga agacaaacuu     1380

ucuggugauc gaauuaagca gguaauggag cacauaugga agcugcagga guucuguaac     1440

agcauggcca aauuggacau cgacggcuac gaauaugcuu accucaaggc cauuguucug     1500

uuuuccccug aucaccccgg guuaaccuca acaagccaaa ucgaaaaauu ccaggagaag     1560

gcacagaugg agcugcaaga cuacgugcag aaaaccuauu cugaagauac uuaccgccua     1620

gccagaaucc ucgucaggcu gccagcucua cgguugaugu ccaguaauau uacggaggaa     1680

cuguucuuua caggacucau aggcaacgug agcaucgacu cuauuauccc uuauauucug     1740

aagauggaga ccgccgaaua caauggucag aucacugggg caucccuuug a              1791


<210>  9401
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TAK1__Homo_sapiens__AAC50118

<400>  9401
augaccagcc ccagccccag aauccagauc aucagcaccg acagcgccgu ggccagcccc       60

cagagaaucc agaucgugac cgaccagcag accggccaga agauccagau cgugaccgcc      120

guggacgcca gcggcagccc caagcagcag uucauccuga ccagccccga cggcgccggc      180

accggcaagg ugauccuggc cagccccgag accagcagcg ccaagcagcu gaucuucacc      240

accagcgaca accuggugcc cggcagaauc cagaucguga ccgacagcgc cagcguggag      300

agacugcugg gcaagaccga cgugcagaga ccccaggugg uggaguacug cguggugugc      360

ggcgacaagg ccagcggcag acacuacggc gccgugagcu gcgagggcug caagggcuuc      420

uucaagagaa gcgugagaaa gaaccugacc uacagcugca gaagcaacca ggacugcauc      480

aucaacaagc accacagaaa cagaugccag uucugcagac ugaagaagug ccuggagaug      540

ggcaugaaga uggagagcgu gcagagcgag agaaagcccu ucgacgugca gagagagaag      600

cccagcaacu gcgccgccag caccgagaag aucuacauca gaaaggaccu gagaagcccc      660

cugaucgcca cccccaccuu cguggccgac aaggacggcg ccagacagac cggccugcug      720

gaccccggca ugcuggugaa cauccagcag ccccugauca gagaggacgg caccgugcug      780

cuggccaccg acagcaaggc cgagaccagc cagggcgccc ugggcacccu ggccaacgug      840

gugaccagcc uggccaaccu gagcgagagc cugaacaacg gcgacaccag cgagauccag      900

cccgaggacc agagcgccag cgagaucacc agagccuucg acacccuggc caaggcccug      960

aacaccaccg acagcagcag cagccccagc cuggccgacg gcaucgacac cagcggcggc     1020

ggcagcaucc acgugaucag cagagaccag agcaccccca ucaucgaggu ggagggcccc     1080

cugcugagcg acacccacgu gaccuucaag cugaccaugc ccagccccau gcccgaguac     1140

cugaacgugc acuacaucug cgagagcgcc agcagacugc uguuccugag caugcacugg     1200

gccagaagca uccccgccuu ccaggcccug ggccaggacu gcaacaccag ccuggugaga     1260

gccugcugga acgagcuguu cacccugggc cuggcccagu gcgcccaggu gaugagccug     1320

agcaccaucc uggccgccau cgugaaccac cugcagaaca gcauccagga ggacaagcug     1380

agcggcgaca gaaucaagca ggugauggag cacaucugga agcugcagga guucugcaac     1440

agcauggcca agcuggacau cgacggcuac gaguacgccu accugaaggc caucgugcug     1500

uucagccccg accaccccgg ccugaccagc accagccaga ucgagaaguu ccaggagaag     1560

gcccagaugg agcugcagga cuacgugcag aagaccuaca gcgaggacac cuacagacug     1620

gccagaaucc uggugagacu gcccgcccug agacugauga gcagcaacau caccgaggag     1680

cuguucuuca ccggccugau cggcaacgug agcaucgaca gcaucauccc cuacauccug     1740

aagauggaga ccgccgagua caacggccag aucaccggcg ccagccugug a              1791


<210>  9402
<211>  1791
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TAK1__Homo_sapiens__AAC50118

<400>  9402
augaccagcc ccuccccuag aauccagauu aucucuacag acagcgccgu ggcuuccccg       60

caacggauuc agaucgucac ggaucagcag accggccaaa agauucagau cguuacagcc      120

guggacgcgu cugggagccc caaacagcag uucauccuga ccuccccuga uggagcuggc      180

acagggaagg ugauucucgc cucucccgag accagcuccg ccaaacaacu gaucuuuaca      240

accagcgaca accuuguccc uggacgcauu cagaucguga cggauucugc uuccguugaa      300

agacugcucg gcaagaccga cgugcagcgg ccccaggucg uggaguacug cguugugugu      360

ggggauaaag ccagcggacg ccacuauggc gcugucucuu gcgaaggcug uaagggguuc      420

uuuaagagau ccgugcggaa aaaucugaca uacagcugcc gcucuaacca agacuguauu      480

aucaauaagc aucacagaaa ccggugccag uucugucgcc uuaaaaagug ccuggagaug      540

ggaaugaaaa uggaauccgu gcagagcgag agaaagccuu uugaugucca acgggagaag      600

ccguccaauu gugccgcguc uaccgaaaag auuuauaucc gcaaggaccu cagaagcccc      660

cugaucgcca caccuaccuu cguugcugau aaagacggcg cccggcagac ggggcugcuc      720

gaucccggaa ugcuggugaa cauucagcag ccucuuaucc gcgaggacgg cacagugcug      780

cucgcuaccg acuccaaggc cgaaacaagc caaggggcgc ugggaacccu ugccaauguc      840

gugaccucuc uggcuaaccu cuccgagagc cugaauaacg gcgauacauc ugagauucag      900

cccgaagacc agagcgccuc cgagaucacg agagcuuuug auacccuggc caaagcccuc      960

aauacaaccg acucuagcuc cagcccgucu cuggcugaug gcauugacac auccggggga     1020

ggcagcaucc auguuaucuc ucgggaucag uccaccccua uuaucgaagu ggaggggccc     1080

cuucugagcg acacgcacgu cacauucaag cucaccaugc cuucccccau gcccgaauac     1140

cugaacgugc auuauauuug cgagucugcg agcagacuuc uguuucucuc caugcacugg     1200

gcccgcucua ucccugcuuu ccaagcccug ggacaggauu guaauaccag ccugguucgg     1260

gccugcugga acgagcucuu uacacugggc cuugcucagu gcgcccaggu gaugucccug     1320

agcaccauuc ucgcggcuau cgucaaucau cugcaaaacu cuauccagga agacaaacuu     1380

uccggggaua gaauuaaaca ggugauggag cacaucugga agcugcagga guucuguaac     1440

agcauggcca aacucgacau ugacggauac gaauaugccu accugaaggc uaucguccug     1500

uuuucuccgg aucaccccgg ccucacaucc acgagccaaa uugaaaaauu ccaggagaag     1560

gcccagaugg agcugcaaga cuacgugcag aaaaccuauu cugaagauac auaccgccuu     1620

gcucggaucc ugguuagacu cccugcccug cgccugauga gcuccaauau uaccgaggaa     1680

cuuuucuuua caggccucau cgggaacgug agcaucgacu cuauuauccc cuauauucug     1740

aagauggaga ccgcggaaua caauggacag aucacgggcg ccucccugug a              1791


<210>  9403
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TBK1__Homo_sapiens__Q9UHD2

<400>  9403

Met Gln Ser Thr Ser Asn His Leu Trp Leu Leu Ser Asp Ile Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Asn Val Phe Arg Gly Arg His Lys Lys Thr Gly 
            20                  25                  30          


Asp Leu Phe Ala Ile Lys Val Phe Asn Asn Ile Ser Phe Leu Arg Pro 
        35                  40                  45              


Val Asp Val Gln Met Arg Glu Phe Glu Val Leu Lys Lys Leu Asn His 
    50                  55                  60                  


Lys Asn Ile Val Lys Leu Phe Ala Ile Glu Glu Glu Thr Thr Thr Arg 
65                  70                  75                  80  


His Lys Val Leu Ile Met Glu Phe Cys Pro Cys Gly Ser Leu Tyr Thr 
                85                  90                  95      


Val Leu Glu Glu Pro Ser Asn Ala Tyr Gly Leu Pro Glu Ser Glu Phe 
            100                 105                 110         


Leu Ile Val Leu Arg Asp Val Val Gly Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Val 
    130                 135                 140                 


Ile Gly Glu Asp Gly Gln Ser Val Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Glu Asp Asp Glu Gln Phe Val Ser Leu Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Asp His Gln Lys Lys Tyr Gly Ala Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Phe Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Arg Pro Phe 
    210                 215                 220                 


Glu Gly Pro Arg Arg Asn Lys Glu Val Met Tyr Lys Ile Ile Thr Gly 
225                 230                 235                 240 


Lys Pro Ser Gly Ala Ile Ser Gly Val Gln Lys Ala Glu Asn Gly Pro 
                245                 250                 255     


Ile Asp Trp Ser Gly Asp Met Pro Val Ser Cys Ser Leu Ser Arg Gly 
            260                 265                 270         


Leu Gln Val Leu Leu Thr Pro Val Leu Ala Asn Ile Leu Glu Ala Asp 
        275                 280                 285             


Gln Glu Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu His Arg Met Val Ile His Val Phe Ser Leu Gln Gln Met Thr 
305                 310                 315                 320 


Ala His Lys Ile Tyr Ile His Ser Tyr Asn Thr Ala Thr Ile Phe His 
                325                 330                 335     


Glu Leu Val Tyr Lys Gln Thr Lys Ile Ile Ser Ser Asn Gln Glu Leu 
            340                 345                 350         


Ile Tyr Glu Gly Arg Arg Leu Val Leu Glu Pro Gly Arg Leu Ala Gln 
        355                 360                 365             


His Phe Pro Lys Thr Thr Glu Glu Asn Pro Ile Phe Val Val Ser Arg 
    370                 375                 380                 


Glu Pro Leu Asn Thr Ile Gly Leu Ile Tyr Glu Lys Ile Ser Leu Pro 
385                 390                 395                 400 


Lys Val His Pro Arg Tyr Asp Leu Asp Gly Asp Ala Ser Met Ala Lys 
                405                 410                 415     


Ala Ile Thr Gly Val Val Cys Tyr Ala Cys Arg Ile Ala Ser Thr Leu 
            420                 425                 430         


Leu Leu Tyr Gln Glu Leu Met Arg Lys Gly Ile Arg Trp Leu Ile Glu 
        435                 440                 445             


Leu Ile Lys Asp Asp Tyr Asn Glu Thr Val His Lys Lys Thr Glu Val 
    450                 455                 460                 


Val Ile Thr Leu Asp Phe Cys Ile Arg Asn Ile Glu Lys Thr Val Lys 
465                 470                 475                 480 


Val Tyr Glu Lys Leu Met Lys Ile Asn Leu Glu Ala Ala Glu Leu Gly 
                485                 490                 495     


Glu Ile Ser Asp Ile His Thr Lys Leu Leu Arg Leu Ser Ser Ser Gln 
            500                 505                 510         


Gly Thr Ile Glu Thr Ser Leu Gln Asp Ile Asp Ser Arg Leu Ser Pro 
        515                 520                 525             


Gly Gly Ser Leu Ala Asp Ala Trp Ala His Gln Glu Gly Thr His Pro 
    530                 535                 540                 


Lys Asp Arg Asn Val Glu Lys Leu Gln Val Leu Leu Asn Cys Met Thr 
545                 550                 555                 560 


Glu Ile Tyr Tyr Gln Phe Lys Lys Asp Lys Ala Glu Arg Arg Leu Ala 
                565                 570                 575     


Tyr Asn Glu Glu Gln Ile His Lys Phe Asp Lys Gln Lys Leu Tyr Tyr 
            580                 585                 590         


His Ala Thr Lys Ala Met Thr His Phe Thr Asp Glu Cys Val Lys Lys 
        595                 600                 605             


Tyr Glu Ala Phe Leu Asn Lys Ser Glu Glu Trp Ile Arg Lys Met Leu 
    610                 615                 620                 


His Leu Arg Lys Gln Leu Leu Ser Leu Thr Asn Gln Cys Phe Asp Ile 
625                 630                 635                 640 


Glu Glu Glu Val Ser Lys Tyr Gln Glu Tyr Thr Asn Glu Leu Gln Glu 
                645                 650                 655     


Thr Leu Pro Gln Lys Met Phe Thr Ala Ser Ser Gly Ile Lys His Thr 
            660                 665                 670         


Met Thr Pro Ile Tyr Pro Ser Ser Asn Thr Leu Val Glu Met Thr Leu 
        675                 680                 685             


Gly Met Lys Lys Leu Lys Glu Glu Met Glu Gly Val Val Lys Glu Leu 
    690                 695                 700                 


Ala Glu Asn Asn His Ile Leu Glu Arg Phe Gly Ser Leu Thr Met Asp 
705                 710                 715                 720 


Gly Gly Leu Arg Asn Val Asp Cys Leu 
                725                 


<210>  9404
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TBK1__Homo_sapiens__AAF05989

<400>  9404
augcagagca cuucuaauca ucuguggcuu uuaucugaua uuuuaggcca aggagcuacu       60

gcaaaugucu uucguggaag acauaagaaa acuggugauu uauuugcuau caaaguauuu      120

aauaacauaa gcuuccuucg uccaguggau guucaaauga gagaauuuga aguguugaaa      180

aaacucaauc acaaaaauau ugucaaauua uuugcuauug aagaggagac aacaacaaga      240

cauaaaguac uuauuaugga auuuugucca ugugggaguu uauacacugu uuuagaagaa      300

ccuucuaaug ccuauggacu accagaaucu gaauucuuaa uuguuuugcg agauguggug      360

gguggaauga aucaucuacg agagaauggu auagugcacc gugauaucaa gccaggaaau      420

aucaugcgug uuauagggga agauggacag ucuguguaca aacucacaga uuuuggugca      480

gcuagagaau uagaagauga ugagcaguuu guuucucugu auggcacaga agaauauuug      540

cacccugaua uguaugagag agcagugcua agaaaagauc aucagaagaa auauggagca      600

acaguugauc uuuggagcau ugggguaaca uuuuaccaug cagcuacugg aucacugcca      660

uuuagacccu uugaagggcc ucguaggaau aaagaaguga uguauaaaau aauuacagga      720

aagccuucug gugcaauauc uggaguacag aaagcagaaa auggaccaau ugacuggagu      780

ggagacaugc cuguuucuug cagucuuucu cggggucuuc agguucuacu uaccccuguu      840

cuugcaaaca uccuugaagc agaucaggaa aaguguuggg guuuugacca guuuuuugca      900

gaaacuagug auauacuuca ccgaauggua auucauguuu uuucgcuaca acaaaugaca      960

gcucauaaga uuuauauuca uagcuauaau acugcuacua uauuucauga acugguauau     1020

aaacaaacca aaauuauuuc uucaaaucaa gaacuuaucu acgaagggcg acgcuuaguc     1080

uuagaaccug gaaggcuggc acaacauuuc ccuaaaacua cugaggaaaa cccuauauuu     1140

guaguaagcc gggaaccucu gaauaccaua ggauuaauau augaaaaaau uucccucccu     1200

aaaguacauc cacguuauga uuuagacggg gaugcuagca uggcuaaggc aauaacaggg     1260

guuguguguu augccugcag aauugccagu accuuacugc uuuaucagga auuaaugcga     1320

aaggggauac gauggcugau ugaauuaauu aaagaugauu acaaugaaac uguucacaaa     1380

aagacagaag uugugaucac auuggauuuc uguaucagaa acauugaaaa aacugugaaa     1440

guauaugaaa aguugaugaa gaucaaccug gaagcggcag aguuagguga aauuucagac     1500

auacacacca aauuguugag acuuuccagu ucucagggaa caauagaaac cagucuucag     1560

gauaucgaca gcagauuauc uccaggugga ucacuggcag acgcaugggc acaucaagaa     1620

ggcacucauc cgaaagacag aaauguagaa aaacuacaag uccuguuaaa uugcaugaca     1680

gagauuuacu aucaguucaa aaaagacaaa gcagaacgua gauuagcuua uaaugaagaa     1740

caaauccaca aauuugauaa gcaaaaacug uauuaccaug ccacaaaagc uaugacgcac     1800

uuuacagaug aauguguuaa aaaguaugag gcauuuuuga auaagucaga agaauggaua     1860

agaaagaugc uucaucuuag gaaacaguua uuaucgcuga cuaaucagug uuuugauauu     1920

gaagaagaag uaucaaaaua ucaagaauau acuaaugagu uacaagaaac ucugccucag     1980

aaaauguuua cagcuuccag uggaaucaaa cauaccauga ccccaauuua uccaaguucu     2040

aacacauuag uagaaaugac ucuugguaug aagaaauuaa aggaagagau ggaaggggug     2100

guuaaagaac uugcugaaaa uaaccacauu uuagaaaggu uuggcucuuu aaccauggau     2160

gguggccuuc gcaacguuga cugucuuuag                                      2190


<210>  9405
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TBK1__Homo_sapiens__AAF05989

<400>  9405
augcagagca ccuccaacca ccuguggcuc cugagcgaca uccugggcca gggggccacc       60

gccaacgugu uccgcggccg gcacaagaag acgggggacc ucuucgcgau caaggucuuc      120

aacaacaucu ccuuccugcg ccccguggac gugcagaugc gggaguucga gguccugaag      180

aagcucaacc acaagaacau cgugaagcug uucgccaucg aggaggagac caccacccgc      240

cacaaggugc ugaucaugga guucugcccg ugcggcagcc ucuacacggu ccuggaggag      300

cccuccaacg ccuacgggcu gcccgagagc gaguuccuca ucgugcugcg ggacgugguc      360

ggcggcauga accaccuccg cgagaacggg aucgugcacc gggacaucaa gcccggcaac      420

aucaugcgcg ugaucgggga ggacggccag uccgucuaca agcugaccga cuucggggcc      480

gcccgggagc uggaggacga cgagcaguuc gugagccugu acggcaccga ggaguaccuc      540

cacccggaca uguacgagcg cgcggugcug cggaaggacc accagaagaa guacggcgcc      600

accgucgacc ugugguccau cggggugacg uucuaccacg ccgccaccgg cagccucccc      660

uuccgccccu ucgaggggcc ccggcgcaac aaggagguga uguacaagau caucaccggc      720

aagccguccg gcgcgaucag cgggguccag aaggccgaga acggccccau cgacuggucc      780

ggggacaugc ccgugagcug cucccugagc cggggccucc aggugcugcu gacccccguc      840

cuggccaaca uccucgaggc cgaccaggag aagugcuggg gguucgacca guucuucgcc      900

gagacguccg acauccugca ccgcauggug auccacgugu ucagccugca gcagaugacc      960

gcgcacaaga ucuacaucca cuccuacaac accgccacca ucuuccacga gcucgucuac     1020

aagcagacga agaucaucag cagcaaccag gagcugaucu acgagggccg gcgccuggug     1080

cucgagccgg gccggcuggc ccagcacuuc cccaagacca ccgaggagaa ccccaucuuc     1140

gucguguccc gcgagccccu gaacaccauc gggcucaucu acgagaagau cagccugccg     1200

aaggugcacc cccgguacga ccuggacggc gacgccucca uggccaaggc gaucacgggg     1260

gucgugugcu acgccugccg caucgccagc acccuccugc uguaccagga gcucaugcgc     1320

aagggcaucc gguggcugau cgagcugauc aaggacgacu acaacgagac cgugcacaag     1380

aagaccgagg ucgugaucac gcucgacuuc ugcauccgca acaucgagaa gaccgugaag     1440

gucuacgaga agcugaugaa gaucaaccug gaggccgccg agcucgggga gaucuccgac     1500

auccacacca agcugcugcg gcugagcucc agccagggca ccaucgagac gucccuccag     1560

gacaucgaca gccgccuguc ccccggcggg agccuggcgg acgccugggc ccaccaggag     1620

ggcacccacc ccaaggaccg gaacguggag aagcuccagg ugcugcugaa cugcaugacc     1680

gagaucuacu accaguucaa gaaggacaag gccgagcgcc ggcucgccua caacgaggag     1740

cagauccaca aguucgacaa gcagaagcug uacuaccacg cgaccaaggc caugacgcac     1800

uucaccgacg agugcgucaa gaaguacgag gccuuccuga acaaguccga ggaguggauc     1860

cgcaagaugc uccaccuccg gaagcagcug cugagccuga ccaaccagug cuucgacauc     1920

gaggaggagg uguccaagua ccaggaguac accaacgagc ugcaggagac gcucccgcag     1980

aagauguuca ccgccagcuc cgggaucaag cacaccauga cccccaucua ccccagcucc     2040

aacacccugg uggagaugac gcugggcaug aagaagcuca aggaggagau ggaggggguc     2100

gugaaggagc uggcggagaa caaccacauc cuggagcgcu ucggcagccu caccauggac     2160

ggcgggcugc ggaacgugga cugccuguga                                      2190


<210>  9406
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TBK1__Homo_sapiens__AAF05989

<400>  9406
augcagucca ccuccaacca ccucuggcuc cucuccgaca uccucggcca gggcgccacc       60

gccaacgucu uccgcggccg ccacaagaag accggcgacc ucuucgccau caaggucuuc      120

aacaacaucu ccuuccuccg ccccgucgac guccagaugc gcgaguucga gguccucaag      180

aagcucaacc acaagaacau cgucaagcuc uucgccaucg aggaggagac caccacccgc      240

cacaaggucc ucaucaugga guucugcccc ugcggcuccc ucuacaccgu ccucgaggag      300

cccuccaacg ccuacggccu ccccgagucc gaguuccuca ucguccuccg cgacgucguc      360

ggcggcauga accaccuccg cgagaacggc aucguccacc gcgacaucaa gcccggcaac      420

aucaugcgcg ucaucggcga ggacggccag uccgucuaca agcucaccga cuucggcgcc      480

gcccgcgagc ucgaggacga cgagcaguuc gucucccucu acggcaccga ggaguaccuc      540

caccccgaca uguacgagcg cgccguccuc cgcaaggacc accagaagaa guacggcgcc      600

accgucgacc ucugguccau cggcgucacc uucuaccacg ccgccaccgg cucccucccc      660

uuccgccccu ucgagggccc ccgccgcaac aaggagguca uguacaagau caucaccggc      720

aagcccuccg gcgccaucuc cggcguccag aaggccgaga acggccccau cgacuggucc      780

ggcgacaugc ccgucuccug cucccucucc cgcggccucc agguccuccu cacccccguc      840

cucgccaaca uccucgaggc cgaccaggag aagugcuggg gcuucgacca guucuucgcc      900

gagaccuccg acauccucca ccgcaugguc auccacgucu ucucccucca gcagaugacc      960

gcccacaaga ucuacaucca cuccuacaac accgccacca ucuuccacga gcucgucuac     1020

aagcagacca agaucaucuc cuccaaccag gagcucaucu acgagggccg ccgccucguc     1080

cucgagcccg gccgccucgc ccagcacuuc cccaagacca ccgaggagaa ccccaucuuc     1140

gucgucuccc gcgagccccu caacaccauc ggccucaucu acgagaagau cucccucccc     1200

aagguccacc cccgcuacga ccucgacggc gacgccucca uggccaaggc caucaccggc     1260

gucgucugcu acgccugccg caucgccucc acccuccucc ucuaccagga gcucaugcgc     1320

aagggcaucc gcuggcucau cgagcucauc aaggacgacu acaacgagac cguccacaag     1380

aagaccgagg ucgucaucac ccucgacuuc ugcauccgca acaucgagaa gaccgucaag     1440

gucuacgaga agcucaugaa gaucaaccuc gaggccgccg agcucggcga gaucuccgac     1500

auccacacca agcuccuccg ccucuccucc ucccagggca ccaucgagac cucccuccag     1560

gacaucgacu cccgccucuc ccccggcggc ucccucgccg acgccugggc ccaccaggag     1620

ggcacccacc ccaaggaccg caacgucgag aagcuccagg uccuccucaa cugcaugacc     1680

gagaucuacu accaguucaa gaaggacaag gccgagcgcc gccucgccua caacgaggag     1740

cagauccaca aguucgacaa gcagaagcuc uacuaccacg ccaccaaggc caugacccac     1800

uucaccgacg agugcgucaa gaaguacgag gccuuccuca acaaguccga ggaguggauc     1860

cgcaagaugc uccaccuccg caagcagcuc cucucccuca ccaaccagug cuucgacauc     1920

gaggaggagg ucuccaagua ccaggaguac accaacgagc uccaggagac ccucccccag     1980

aagauguuca ccgccuccuc cggcaucaag cacaccauga cccccaucua ccccuccucc     2040

aacacccucg ucgagaugac ccucggcaug aagaagcuca aggaggagau ggagggcguc     2100

gucaaggagc ucgccgagaa caaccacauc cucgagcgcu ucggcucccu caccauggac     2160

ggcggccucc gcaacgucga cugccucuga                                      2190


<210>  9407
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TBK1__Homo_sapiens__AAF05989

<400>  9407
augcagagca ccuccaacca ccuguggcuc cuuucugaca uccugggcca aggggccaca       60

gcuaaugugu ucagaggaag gcauaagaaa acuggugauu uguuugcaau uaaggucuuc      120

aacaauauau cauuuuuacg gcccguugac gugcagaugc gcgaguucga aguacugaaa      180

aagcuaaacc acaaaaauau cgugaagcuc uuugccauug aggaagagac gaccacacga      240

cauaaggucc ugaucaugga guucugcccu uguggcaguc uuuacacugu gcuggaggag      300

ccaagcaacg cguauggguu gccggaaucc gaguuucuca uuguucugcg ugaugugguc      360

ggaggcauga aucaccugag agaaaacggu aucgugcaua gggacauaaa acccgggaau      420

aucaugcggg uaauuggaga ggauggccag ucuguuuaca agcucaccga cuucggcgcu      480

gcccgcgagu uagaagauga cgagcaguuu gugucgcugu augggacaga agaguaccuu      540

cacccugaua uguaugaaag agcagucuug aggaaagacc accaaaagaa auacggagcc      600

accguggauc uguggucaau cggugugacu uucuaucaug cugcaacagg cagccuacca      660

uuucggcccu ucgaggggcc ucgccgaaac aaggagguca uguacaagau uaucaccgga      720

aaaccaagug gcgccauauc cgguguucag aaggcugaaa augggcccau ugacuggucu      780

ggagauaugc cugugagcug cucccucuca agaggccugc agguacuucu gacgccagug      840

uuggccaaca uccucgaggc ggaccaggaa aaauguuggg gcuuugacca auucuucgca      900

gagaccagug auauucugca caggaugguc auccaugugu uuagcuuaca gcagaugacu      960

gcccacaaga ucuacauuca cucuuauaau acagcuacua uauuccauga acugguuuac     1020

aaacagacca agaucauuuc cucaaaccaa gagcucaucu augaggggcg gcgucuugug     1080

cuggaaccgg gacgcuuggc ccagcacuuu cccaaaacaa ccgaggaaaa uccuauauuc     1140

gucgugagca gagagccacu aaacacgauu ggucugaucu acgaaaagau cagucucccc     1200

aagguacauc cuagguauga ccuggauggc gacgcaucua uggcuaaagc cauuacuggg     1260

guugugugcu acgcgugucg gaucgccucc acacuucugu uguaucagga gcucaugcga     1320

aagggcauuc gcuggcugau agaguuaauc aaagaugacu acaacgaaac cguccacaag     1380

aaaacugagg uggucauuac acuggauuuu ugcaucagaa auaucgaaaa gaccgugaag     1440

guuuacgaga aacuaaugaa gauuaaccuc gaggcagcug aacugggaga gauaagcgac     1500

auccauacga aacuuuugag gcugucgucu ucccaaggua ccauugaaac aucacuccag     1560

gauaucgaca gucggcugag cccagggggc ucccuugccg augcuugggc ccaccaggag     1620

ggaacucacc ccaaggaccg caauguggaa aaacugcagg uauugcucaa cuguaugacc     1680

gagauuuauu accaauucaa gaaggacaaa gcagagagaa ggcuggccua uaaugaagaa     1740

cagauccaua aguuugauaa acagaaguua uacuaucacg cuacaaaagc gaugacucau     1800

uucaccgacg aaugcgucaa gaaguacgag gcauuucuga acaaaucuga agaguggaua     1860

cguaagaugc uacaccuccg gaaacagcug cuuagcuuga caaaucaaug uuucgauauc     1920

gaggaagagg ugucaaagua ucaggaauac accaacgagc ugcaggaaac ucucccgcag     1980

aaaauguuua cggccaguuc cggcauuaag cacacaauga ccccuaucua ccccagcucu     2040

aauacucugg uugagaugac cuuagggaug aaaaagcuga aggaggaaau ggagggagug     2100

gucaaagaac uugcugagaa caaucauauu uuggagcgau ucgguucacu cacaauggac     2160

ggcgggcuga gaaacgugga uugccuauga                                      2190


<210>  9408
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TBK1__Homo_sapiens__AAF05989

<400>  9408
augcagagca ccagcaacca ccuguggcug cugagcgaca uccugggcca gggcgccacc       60

gccaacgugu ucagaggcag acacaagaag accggcgacc uguucgccau caagguguuc      120

aacaacauca gcuuccugag acccguggac gugcagauga gagaguucga ggugcugaag      180

aagcugaacc acaagaacau cgugaagcug uucgccaucg aggaggagac caccaccaga      240

cacaaggugc ugaucaugga guucugcccc ugcggcagcc uguacaccgu gcuggaggag      300

cccagcaacg ccuacggccu gcccgagagc gaguuccuga ucgugcugag agacguggug      360

ggcggcauga accaccugag agagaacggc aucgugcaca gagacaucaa gcccggcaac      420

aucaugagag ugaucggcga ggacggccag agcguguaca agcugaccga cuucggcgcc      480

gccagagagc uggaggacga cgagcaguuc gugagccugu acggcaccga ggaguaccug      540

caccccgaca uguacgagag agccgugcug agaaaggacc accagaagaa guacggcgcc      600

accguggacc uguggagcau cggcgugacc uucuaccacg ccgccaccgg cagccugccc      660

uucagacccu ucgagggccc cagaagaaac aaggagguga uguacaagau caucaccggc      720

aagcccagcg gcgccaucag cggcgugcag aaggccgaga acggccccau cgacuggagc      780

ggcgacaugc ccgugagcug cagccugagc agaggccugc aggugcugcu gacccccgug      840

cuggccaaca uccuggaggc cgaccaggag aagugcuggg gcuucgacca guucuucgcc      900

gagaccagcg acauccugca cagaauggug auccacgugu ucagccugca gcagaugacc      960

gcccacaaga ucuacaucca cagcuacaac accgccacca ucuuccacga gcugguguac     1020

aagcagacca agaucaucag cagcaaccag gagcugaucu acgagggcag aagacuggug     1080

cuggagcccg gcagacuggc ccagcacuuc cccaagacca ccgaggagaa ccccaucuuc     1140

guggugagca gagagccccu gaacaccauc ggccugaucu acgagaagau cagccugccc     1200

aaggugcacc ccagauacga ccuggacggc gacgccagca uggccaaggc caucaccggc     1260

guggugugcu acgccugcag aaucgccagc acccugcugc uguaccagga gcugaugaga     1320

aagggcauca gauggcugau cgagcugauc aaggacgacu acaacgagac cgugcacaag     1380

aagaccgagg uggugaucac ccuggacuuc ugcaucagaa acaucgagaa gaccgugaag     1440

guguacgaga agcugaugaa gaucaaccug gaggccgccg agcugggcga gaucagcgac     1500

auccacacca agcugcugag acugagcagc agccagggca ccaucgagac cagccugcag     1560

gacaucgaca gcagacugag ccccggcggc agccuggccg acgccugggc ccaccaggag     1620

ggcacccacc ccaaggacag aaacguggag aagcugcagg ugcugcugaa cugcaugacc     1680

gagaucuacu accaguucaa gaaggacaag gccgagagaa gacuggccua caacgaggag     1740

cagauccaca aguucgacaa gcagaagcug uacuaccacg ccaccaaggc caugacccac     1800

uucaccgacg agugcgugaa gaaguacgag gccuuccuga acaagagcga ggaguggauc     1860

agaaagaugc ugcaccugag aaagcagcug cugagccuga ccaaccagug cuucgacauc     1920

gaggaggagg ugagcaagua ccaggaguac accaacgagc ugcaggagac ccugccccag     1980

aagauguuca ccgccagcag cggcaucaag cacaccauga cccccaucua ccccagcagc     2040

aacacccugg uggagaugac ccugggcaug aagaagcuga aggaggagau ggagggcgug     2100

gugaaggagc uggccgagaa caaccacauc cuggagagau ucggcagccu gaccauggac     2160

ggcggccuga gaaacgugga cugccuguga                                      2190


<210>  9409
<211>  2190
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TBK1__Homo_sapiens__AAF05989

<400>  9409
augcagagca ccuccaacca ccuguggcuc cugucugaca uccuuggcca aggggccaca       60

gcuaaugugu ucagaggacg gcauaagaaa acgggcgauc uguuugccau uaaggucuuc      120

aacaauauca gcuuucuccg ccccguugac gugcagauga gagaguucga agugcugaaa      180

aagcugaacc acaaaaauau ugucaagcug uuugcgaucg aggaagagac cacaacccgg      240

cauaaggugc ucauuaugga guucugcccu uguggguccc uguacacagu ucuggaggag      300

ccgucuaacg cuuauggacu ccccgaaagc gaguuucuga ucgugcuucg cgaugucgug      360

ggcgggauga aucaccugag agaaaacgga aucguucauc gggacauuaa accuggcaau      420

aucaugcgcg ugauuggcga ggaugggcag uccgucuaca agcucaccga cuucggagcc      480

gccagagagc uggaagauga cgagcaguuu gugucucuuu auggcacaga agaguaccug      540

caccccgaua uguaugaacg ggcugugcuc cgcaaagacc accaaaagaa auacggggcc      600

accgucgauc uguggagcau cggaguuacg uucuaucaug cugccaccgg cucccugccu      660

uuuagacccu ucgaggggcc ucggcgcaac aaggagguga uguacaagau uaucacagga      720

aaaccgagcg gcgcgauuuc uggcgugcag aaggccgaaa augggcccau cgacuggucc      780

ggagauaugc cugucagcug cucucucucc agaggccuuc aggugcuucu gacccccguu      840

cucgcuaaca uccuggaggc cgaccaggaa aaauguuggg gguuugacca auucuucgcu      900

gagacaagcg auauucuuca ccggauggug auccaugucu uuucucugca gcagaugacc      960

gcccacaaga uuuacaucca cuccuauaau acggcgacaa uuuuccauga acucguguac     1020

aaacagacca agaucaucag cuccaaccaa gagcugauuu augagggacg cagacugguu     1080

cucgaaccug gccggcuggc ccagcacuuu cccaaaacaa ccgaggaaaa uccgaucuuc     1140

guggucucua gagagccucu uaacaccauu gggcugaucu acgaaaagau uagccucccc     1200

aaggugcauc cucgcuauga ccuggaugga gacgcuucca uggccaaagc uaucacaggc     1260

gucgugugcu acgccugucg gaucgccagc acgcuucugc ucuaucagga gcugaugaga     1320

aagggcauuc gcuggcugau cgagcucauu aaagaugacu acaacgaaac cguucacaag     1380

aaaacagagg uggucaucac ccuggauuuu ugcauucgga auaucgaaaa gacagugaag     1440

guuuacgaga aacuuaugaa gauuaaccug gaggcugcgg aacucgggga gaucucugac     1500

auccauacca aacugcugag acuuuccagc ucucaaggaa cgauugaaac aagccuccag     1560

gauaucgacu cccgccuguc ucccggcggg agccuggccg augcuugggc ccaccaggag     1620

ggaacccacc ccaaggaccg gaauguggaa aaacuccagg uccugcuuaa cuguaugacc     1680

gagauuuauu accaauucaa gaaggacaaa gccgagagac gccuggcuua uaaugaagaa     1740

cagauccaua aguuugauaa acagaagcuc uacuaucacg ccacaaaagc gaugacccau     1800

uucacagacg aaugcgugaa gaaguacgag gcuuuucuga acaaauccga agaguggauu     1860

cggaagaugc ugcaccuuag aaaacagcuc cugagccuga cgaaucaaug uuucgauauc     1920

gaggaagagg ugucuaagua ucaggaauac accaacgagc uccaggaaac acugccucag     1980

aaaauguuua ccgccuccag cggcaucaag cacacaauga ccccgauuua ccccucuucc     2040

aauacgcuug uugagaugac ccuggggaug aaaaagcuca aggaggaaau ggagggcguc     2100

gugaaagaac uggccgagaa caaucauauc cuggagcgcu ucggaagccu uacaauggac     2160

ggcgggcucc ggaacgugga uugccuguga                                      2190


<210>  9410
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TICAM1__Homo_sapiens__Q8IUC6

<400>  9410

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln 
        675                 680                 685             


Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210>  9411
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TICAM1__Homo_sapiens__AAI36557

<400>  9411
auggccugca cgggcccauc acuuccuagc gccuucgaca uucuaggugc agcaggccag       60

gacaagcucu uguaucugaa gcacaaacug aagaccccac gcccaggcug ccaggggcag      120

gaccuccugc augccauggu ucuccugaag cugggccagg aaacugaggc caggaucucu      180

cuagaggcau ugaaggccga ugcgguggcc cggcuggugg cccgccagug ggcuggcgug      240

gacagcaccg aggacccaga ggagccccca gauguguccu gggcuguggc ccgcuuguac      300

caccugcugg cugaggagaa gcugugcccc gccucgcugc gggacguggc cuaccaggaa      360

gccguccgca cccucagcuc cagggacgac caccggcugg gggaacuuca ggaugaggcc      420

cgaaaccggu guggguggga cauugcuggg gauccaggga gcauccggac gcuccagucc      480

aaucugggcu gccucccacc auccucggcu uugcccucug ggaccaggag ccucccacgc      540

cccauugacg guguuucgga cuggagccaa gggugcuccc ugcgauccac uggcagcccu      600

gccucccugg ccagcaacuu ggaaaucagc caguccccua ccaugcccuu ccucagccug      660

caccgcagcc cacaugggcc cagcaagcuc ugugacgacc cccaggccag cuuggugccc      720

gagccugucc ccgguggcug ccaggagccu gaggagauga gcuggccgcc aucgggggag      780

auugccagcc caccagagcu gccaagcagc ccaccuccug ggcuucccga aguggcccca      840

gaugcaaccu ccacuggccu cccugauacc cccgcagcuc cagaaaccag caccaacuac      900

ccaguggagu gcaccgaggg gucugcaggc ccccagucuc uccccuugcc uauucuggag      960

ccggucaaaa accccugcuc ugucaaagac cagacgccac uccaacuuuc uguagaagau     1020

accaccucuc caaauaccaa gccgugccca ccuacuccca ccaccccaga aacauccccu     1080

ccuccuccuc cuccuccucc uucaucuacu ccuuguucag cucaccugac ccccuccucc     1140

cuguucccuu ccucccugga aucaucaucg gaacagaaau ucuauaacuu ugugauccuc     1200

cacgccaggg cagacgaaca caucgcccug cggguucggg agaagcugga ggcccuuggc     1260

gugcccgacg gggccaccuu cugcgaggau uuccaggugc cggggcgcgg ggagcugagc     1320

ugccugcagg acgccauaga ccacucagcu uucaucaucc uacuucucac cuccaacuuc     1380

gacugucgcc ugagccugca ccaggugaac caagccauga ugagcaaccu cacgcgacag     1440

gggucgccag acugugucau ccccuuccug ccccuggaga gcuccccggc ccagcucagc     1500

uccgacacgg ccagccugcu cuccgggcug gugcggcugg acgaacacuc ccagaucuuc     1560

gccaggaagg uggccaacac cuucaagccc cacaggcuuc aggcccgaaa ggccaugugg     1620

aggaaggaac aggacacccg agcccugcgg gaacagagcc aacaccugga uggugagcgg     1680

augcaggcgg cggcacugaa cgcagccuac ucagccuacc uccagagcua cuuguccuac     1740

caggcacaga uggagcagcu ccagguggcu uuugggagcc acaugucauu ugggacuggg     1800

gcgcccuaug gggcucgaau gcccuuuggg ggccaggugc cccugggagc cccgccaccc     1860

uuucccacuu ggccggggug cccgcagccg ccaccccugc acgcauggca ggcuggcacc     1920

cccccaccgc ccuccccaca gccagcagcc uuuccacagu cacugcccuu cccgcagucc     1980

ccagccuucc cuacggccuc acccgcaccc ccucagagcc cagggcugca accccucauu     2040

auccaccacg cacagauggu acagcugggg cugaacaacc acauguggaa ccagagaggg     2100

ucccaggcgc ccgaggacaa gacgcaggag gcagaauga                            2139


<210>  9412
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TICAM1__Homo_sapiens__AAI36557

<400>  9412
auggccugca ccggccccag ccugccgucc gccuucgaca uccucggggc ggccggccag       60

gacaagcugc uguaccucaa gcacaagcug aagacgcccc gccccgggug ccagggccag      120

gaccugcucc acgccauggu gcugcugaag cucgggcagg agaccgaggc ccggaucagc      180

cuggaggccc ugaaggcgga cgccgucgcc cgccucgugg cccggcagug ggcgggcgug      240

gacuccaccg aggaccccga ggagccgccc gacgucagcu gggccguggc ccgccuguac      300

caccuccucg ccgaggagaa gcugugcccc gccucccugc gggacguggc guaccaggag      360

gccguccgca cccucagcuc ccgggacgac caccgccugg gcgagcugca ggacgaggcc      420

cggaaccgcu gcggguggga caucgccggc gaccccggga gcauccggac ccuccagucc      480

aaccugggcu gccugccgcc cagcuccgcc cuccccagcg ggacgcgcuc ccugccccgg      540

ccgaucgacg gcgugagcga cuggucccag ggcugcagcc ugcgcuccac cgggagcccc      600

gcgucccucg ccagcaaccu ggagaucagc caguccccca ccaugcccuu ccugagccuc      660

caccgguccc cgcacggccc cagcaagcug ugcgacgacc cccaggccuc ccuggugccc      720

gagccggucc ccgggggcug ccaggagccc gaggagauga gcuggccccc guccggcgag      780

aucgccagcc cgcccgagcu gcccuccagc ccgccgcccg ggcugcccga gguggccccc      840

gacgcgaccu ccacgggccu gcccgacacc cccgccgccc ccgagaccag caccaacuac      900

cccguggagu gcacggaggg guccgccggc ccccagagcc ucccccugcc gauccuggag      960

cccgucaaga accccugcuc cgugaaggac cagacgcccc uccagcugag cguggaggac     1020

accaccuccc cgaacaccaa gcccugcccg cccaccccca ccacccccga gacgagcccg     1080

ccgcccccgc cgccgccgcc cuccagcacc cccugcagcg cccaccugac ccccuccagc     1140

cucuuccccu ccagccugga guccagcucc gagcagaagu ucuacaacuu cgucauccug     1200

cacgcgcgcg ccgacgagca caucgcccuc cgggugcgcg agaagcugga ggcccugggg     1260

gugcccgacg gcgcgaccuu cugcgaggac uuccaggucc ccggccgcgg ggagcucagc     1320

ugccugcagg acgccaucga ccacuccgcc uucaucaucc ugcugcucac gagcaacuuc     1380

gacugccggc ugucccugca ccaggugaac caggccauga ugagcaaccu cacccggcag     1440

ggcucccccg acugcgugau ccccuuccug ccccuggaga gcucccccgc ccagcucagc     1500

uccgacaccg cgagccugcu gagcgggcuc guccgccugg acgagcacuc ccagaucuuc     1560

gcccgcaagg uggccaacac cuucaagccc caccggcugc aggcccgcaa ggccaugugg     1620

cggaaggagc aggacacgcg cgcgcuccgg gagcagagcc agcaccugga cggcgagcgc     1680

augcaggccg ccgcccugaa cgccgcguac uccgccuacc uccagagcua ccuguccuac     1740

caggcccaga uggagcagcu ccagguggcc uucgggagcc acauguccuu cggcaccggc     1800

gcgcccuacg gggcccggau gcccuucggc gggcaggucc cccugggcgc gcccccgccc     1860

uuccccaccu ggcccgggug cccccagccg ccgccccugc acgccuggca ggccggcacg     1920

ccgcccccgc ccagccccca gcccgccgcc uucccccagu cccugcccuu cccccagagc     1980

cccgccuucc ccaccgccuc ccccgccccg ccccagagcc ccggccucca gccccugauc     2040

auccaccacg cgcagauggu gcagcugggg cucaacaacc acauguggaa ccagcgcggc     2100

ucccaggccc ccgaggacaa gacccaggag gccgaguga                            2139


<210>  9413
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TICAM1__Homo_sapiens__AAI36557

<400>  9413
auggccugca ccggccccuc ccuccccucc gccuucgaca uccucggcgc cgccggccag       60

gacaagcucc ucuaccucaa gcacaagcuc aagacccccc gccccggcug ccagggccag      120

gaccuccucc acgccauggu ccuccucaag cucggccagg agaccgaggc ccgcaucucc      180

cucgaggccc ucaaggccga cgccgucgcc cgccucgucg cccgccagug ggccggcguc      240

gacuccaccg aggaccccga ggagcccccc gacgucuccu gggccgucgc ccgccucuac      300

caccuccucg ccgaggagaa gcucugcccc gccucccucc gcgacgucgc cuaccaggag      360

gccguccgca cccucuccuc ccgcgacgac caccgccucg gcgagcucca ggacgaggcc      420

cgcaaccgcu gcggcuggga caucgccggc gaccccggcu ccauccgcac ccuccagucc      480

aaccucggcu gccucccccc cuccuccgcc cuccccuccg gcacccgcuc ccucccccgc      540

cccaucgacg gcgucuccga cuggucccag ggcugcuccc uccgcuccac cggcuccccc      600

gccucccucg ccuccaaccu cgagaucucc caguccccca ccaugcccuu ccucucccuc      660

caccgcuccc cccacggccc cuccaagcuc ugcgacgacc cccaggccuc ccucgucccc      720

gagcccgucc ccggcggcug ccaggagccc gaggagaugu ccuggccccc cuccggcgag      780

aucgccuccc cccccgagcu ccccuccucc cccccccccg gccuccccga ggucgccccc      840

gacgccaccu ccaccggccu ccccgacacc cccgccgccc ccgagaccuc caccaacuac      900

cccgucgagu gcaccgaggg cuccgccggc ccccaguccc ucccccuccc cauccucgag      960

cccgucaaga accccugcuc cgucaaggac cagacccccc uccagcucuc cgucgaggac     1020

accaccuccc ccaacaccaa gcccugcccc cccaccccca ccacccccga gaccuccccc     1080

cccccccccc cccccccccc cuccuccacc cccugcuccg cccaccucac ccccuccucc     1140

cucuuccccu ccucccucga guccuccucc gagcagaagu ucuacaacuu cgucauccuc     1200

cacgcccgcg ccgacgagca caucgcccuc cgcguccgcg agaagcucga ggcccucggc     1260

guccccgacg gcgccaccuu cugcgaggac uuccaggucc ccggccgcgg cgagcucucc     1320

ugccuccagg acgccaucga ccacuccgcc uucaucaucc uccuccucac cuccaacuuc     1380

gacugccgcc ucucccucca ccaggucaac caggccauga uguccaaccu cacccgccag     1440

ggcucccccg acugcgucau ccccuuccuc ccccucgagu ccucccccgc ccagcucucc     1500

uccgacaccg ccucccuccu cuccggccuc guccgccucg acgagcacuc ccagaucuuc     1560

gcccgcaagg ucgccaacac cuucaagccc caccgccucc aggcccgcaa ggccaugugg     1620

cgcaaggagc aggacacccg cgcccuccgc gagcaguccc agcaccucga cggcgagcgc     1680

augcaggccg ccgcccucaa cgccgccuac uccgccuacc uccaguccua ccucuccuac     1740

caggcccaga uggagcagcu ccaggucgcc uucggcuccc acauguccuu cggcaccggc     1800

gcccccuacg gcgcccgcau gcccuucggc ggccaggucc cccucggcgc cccccccccc     1860

uuccccaccu ggcccggcug cccccagccc cccccccucc acgccuggca ggccggcacc     1920

cccccccccc ccucccccca gcccgccgcc uucccccagu cccuccccuu cccccagucc     1980

cccgccuucc ccaccgccuc ccccgccccc ccccaguccc ccggccucca gccccucauc     2040

auccaccacg cccagauggu ccagcucggc cucaacaacc acauguggaa ccagcgcggc     2100

ucccaggccc ccgaggacaa gacccaggag gccgaguga                            2139


<210>  9414
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TICAM1__Homo_sapiens__AAI36557

<400>  9414
auggccugca ccggccccag ccugccuucc gcuuucgaca uccucggggc agccggacag       60

gauaagcugc uguacuugaa acacaaguua aaaacaccaa gaccggguug ucaaggccag      120

gaccugcuac augcgauggu gcuccugaaa cuugggcagg agacugaagc uaggauuucu      180

cuggaggccu ugaaggcaga ugccgucgcu cggcucguug cacgccagug ggccggagug      240

gacucaacgg aagaucccga ggaaccucca gacguaaguu gggcuguggc ccgacuguau      300

caccuucucg cggaggagaa guuaugcccc gcaagccugc gugaugucgc cuaccaagaa      360

gcugugagaa cccuuuccuc uagggacgau caucgguugg gcgagcugca ggacgaagcc      420

cgcaacagau gugguuggga uauagcaggg gacccuggau cgaucaggac acuacaguca      480

aaucucggcu gccugccacc cagcagugcc cuuccuuccg gcacucgguc ucugccacgc      540

ccgauugaug ggguuagcga cuggucccag ggauguucau ugcgaaguac cgguagcccc      600

gcuucucucg cguccaaccu ggagaucuca caaagcccua caaugccauu uuuaagucug      660

cacagaucuc cccauggccc uuccaagcuc ugcgacgauc cacaggccag ccuugugccc      720

gagccggucc cugggggaug ucaggaaccc gaggaaaugu cguggccacc uucuggcgag      780

auugcauccc cuccagaacu gcccucaagu ccuccaccgg guuugcccga gguggcuccu      840

gacgccacca gcacugggcu accagauaca cccgcugccc cugagaccuc cacgaauuau      900

ccaguagaau gcacugaggg aucugcaggc ccccagagcc ugccgcuccc uauccuggaa      960

ccaguuaaaa accccuguuc agugaaggac caaaccccuc uucagcugag ugucgaggau     1020

acaacuuccc ccaauaccaa accaugcccu cccacaccaa ccacgccgga aacuagcccu     1080

cccccacccc cuccaccccc uucuucaaca ccguguagug cccacuugac cccaagcucc     1140

cucuuccccu cuucgcugga gagcuccuca gagcagaagu uuuacaacuu cgugauauua     1200

cacgcuaggg cggacgaaca uaucgcacug cgggugcgug agaaacuaga agcccucggc     1260

gucccugaug gggcuacuuu uugcgaggac uuccaaguuc caggacgcgg ugaacugagu     1320

ugccuucagg augccauuga ccacucugca uuuaucauuu ugcugcucac aagcaauuuc     1380

gauuguagac ugucccuuca ucaggugaac caggccauga ugucaaaucu gaccaggcaa     1440

ggcagccccg acugcguaau ccccuuuuug ccgcucgagu cuucccccgc ucagcugagu     1500

agcgacacgg ccucuuuacu guccgggcua gugcggcucg augagcacuc acagauauuc     1560

gcacgaaagg ucgcgaacac cuuuaagcca caccgccugc aggcuagaaa agccaugugg     1620

aggaaggaac aagacacacg ggcacuucgc gagcagaguc agcauuugga uggagaaaga     1680

augcaggccg cugcccugaa ugcagcuuau agcgccuacc uccaaucgua ucuguccuac     1740

caggcgcaga uggagcaguu acaaguggcc uucggcucuc acaugagcuu ugguacuggg     1800

gcuccuuacg gcgcaaggau gcccuucgga ggccagguuc cacugggggc cccuccccca     1860

uucccgaccu ggccuggaug uccccagcca cccccucuuc augcuuggca agccgguaca     1920

ccacccccuc cgucaccaca gcccgcagcg uuuccucaga guuugcccuu cccacagucc     1980

ccugccuuuc ccacugcuuc uccagccccu ccgcaaagcc ccggccucca gccacugauu     2040

auccaccaug cacagauggu gcagcuaggg cugaacaauc acauguggaa ccaacgugga     2100

ucccaggcuc cugaggacaa aacccaggaa gccgaguga                            2139


<210>  9415
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TICAM1__Homo_sapiens__AAI36557

<400>  9415
auggccugca ccggccccag ccugcccagc gccuucgaca uccugggcgc cgccggccag       60

gacaagcugc uguaccugaa gcacaagcug aagaccccca gacccggcug ccagggccag      120

gaccugcugc acgccauggu gcugcugaag cugggccagg agaccgaggc cagaaucagc      180

cuggaggccc ugaaggccga cgccguggcc agacuggugg ccagacagug ggccggcgug      240

gacagcaccg aggaccccga ggagcccccc gacgugagcu gggccguggc cagacuguac      300

caccugcugg ccgaggagaa gcugugcccc gccagccuga gagacguggc cuaccaggag      360

gccgugagaa cccugagcag cagagacgac cacagacugg gcgagcugca ggacgaggcc      420

agaaacagau gcggcuggga caucgccggc gaccccggca gcaucagaac ccugcagagc      480

aaccugggcu gccugccccc cagcagcgcc cugcccagcg gcaccagaag ccugcccaga      540

cccaucgacg gcgugagcga cuggagccag ggcugcagcc ugagaagcac cggcagcccc      600

gccagccugg ccagcaaccu ggagaucagc cagagcccca ccaugcccuu ccugagccug      660

cacagaagcc cccacggccc cagcaagcug ugcgacgacc cccaggccag ccuggugccc      720

gagcccgugc ccggcggcug ccaggagccc gaggagauga gcuggccccc cagcggcgag      780

aucgccagcc cccccgagcu gcccagcagc cccccccccg gccugcccga gguggccccc      840

gacgccacca gcaccggccu gcccgacacc cccgccgccc ccgagaccag caccaacuac      900

cccguggagu gcaccgaggg cagcgccggc ccccagagcc ugccccugcc cauccuggag      960

cccgugaaga accccugcag cgugaaggac cagacccccc ugcagcugag cguggaggac     1020

accaccagcc ccaacaccaa gcccugcccc cccaccccca ccacccccga gaccagcccc     1080

cccccccccc cccccccccc cagcagcacc cccugcagcg cccaccugac ccccagcagc     1140

cuguucccca gcagccugga gagcagcagc gagcagaagu ucuacaacuu cgugauccug     1200

cacgccagag ccgacgagca caucgcccug agagugagag agaagcugga ggcccugggc     1260

gugcccgacg gcgccaccuu cugcgaggac uuccaggugc ccggcagagg cgagcugagc     1320

ugccugcagg acgccaucga ccacagcgcc uucaucaucc ugcugcugac cagcaacuuc     1380

gacugcagac ugagccugca ccaggugaac caggccauga ugagcaaccu gaccagacag     1440

ggcagccccg acugcgugau ccccuuccug ccccuggaga gcagccccgc ccagcugagc     1500

agcgacaccg ccagccugcu gagcggccug gugagacugg acgagcacag ccagaucuuc     1560

gccagaaagg uggccaacac cuucaagccc cacagacugc aggccagaaa ggccaugugg     1620

agaaaggagc aggacaccag agcccugaga gagcagagcc agcaccugga cggcgagaga     1680

augcaggccg ccgcccugaa cgccgccuac agcgccuacc ugcagagcua ccugagcuac     1740

caggcccaga uggagcagcu gcagguggcc uucggcagcc acaugagcuu cggcaccggc     1800

gcccccuacg gcgccagaau gcccuucggc ggccaggugc cccugggcgc cccccccccc     1860

uuccccaccu ggcccggcug cccccagccc cccccccugc acgccuggca ggccggcacc     1920

cccccccccc ccagccccca gcccgccgcc uucccccaga gccugcccuu cccccagagc     1980

cccgccuucc ccaccgccag ccccgccccc ccccagagcc ccggccugca gccccugauc     2040

auccaccacg cccagauggu gcagcugggc cugaacaacc acauguggaa ccagagaggc     2100

agccaggccc ccgaggacaa gacccaggag gccgaguga                            2139


<210>  9416
<211>  2139
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TICAM1__Homo_sapiens__AAI36557

<400>  9416
auggccugca ccggccccag ccugccuucc gcuuucgaca uccucggggc cgcgggacag       60

gauaagcugc uuuaccugaa acacaagcuc aaaacaccga gacccggcug ucaagggcag      120

gaccugcuuc augcuauggu gcugcucaag cugggacagg agacggaagc ccggauuucu      180

cuggaggccc ucaaagcuga ugccgucgcu cgccugguug ccagacagug ggcgggcgug      240

gacagcaccg aagauccuga ggaacccccu gacguguccu gggccgucgc ucggcuuuau      300

caucugcucg ccgaggagaa gcugugcccc gcuucucuuc gcgauguggc cuaccaagaa      360

gcgguuagaa cacugagcuc ccgggacgau caccgccucg gggagcugca ggacgaagcc      420

agaaaccggu guggauggga uaucgcuggc gacccuggcu cuauucgcac ccugcagagc      480

aaucucgggu gccugccgcc cuccagcgcc cuuccuucug gaacaagauc ccugccccgg      540

ccuaucgaug gcgugagcga cuggucucag ggguguuccc uccgcagcac cggaucuccc      600

gcuucccugg ccagcaaccu ugagauuucc caaucuccga caaugccuuu ucugagccuc      660

cacagauccc cgcauggccc uagcaagcug ugcgacgauc cccaggccuc ucuggucccc      720

gagccugugc ccgggggaug ucaggaaccc gaggaaaugu ccuggccucc cagcggcgag      780

aucgcuucuc cucccgaacu cccgagcucc ccucccccug gccugcccga gguugcgccu      840

gacgccaccu cuacggggcu ucccgauacc ccggcugccc cugagacaag caccaauuau      900

cccguggaau gcacagaggg auccgccggc ccccagagcc ugccucuccc gauccuggaa      960

cccgucaaaa acccuuguuc ugugaaggac caaacgcccc uucagcuguc cguggaggau     1020

accacaagcc cuaauaccaa acccugcccu cccacaccga ccaccccuga aacaucuccc     1080

ccucccccgc cucccccucc cuccagcacg cccuguuccg cucaccucac cccuucuagc     1140

cuguucccgu ccucucugga gagcuccagc gagcagaagu uuuacaacuu cgucauucuc     1200

cacgcccggg cggacgaaca uaucgcucug cgcguuagag agaaacuuga agcccugggg     1260

gugcccgaug gagccacauu uugcgaggac uuccaagugc cuggcagagg ggaacucucu     1320

ugccugcagg augcuauuga ccacuccgcc uuuaucauuc ugcuucucac cagcaauuuc     1380

gauugucggc ugucucugca ucaggucaac caggcuauga uguccaaucu cacacgccaa     1440

ggaagccccg acugcgugau cccuuuucug ccccuugagu cuagcccugc ccagcugucc     1500

agcgacaccg cgucucuccu guccggccug guucggcuug augagcacag ccagauuuuc     1560

gccagaaagg uggcuaacac guuuaagccg caccgccucc aggcccggaa agcuaugugg     1620

agaaaggaac aagacacacg cgcccugcgg gagcaguccc agcaucugga uggcgaaaga     1680

augcaggcgg ccgcucucaa ugccgcuuau ucugccuacc ugcaaagcua ucuuuccuac     1740

caggcccaga uggagcagcu gcaagucgcu uucgggucuc acaugagcuu uggaaccggc     1800

gcgcccuacg gggcccgcau gccuuucgga ggccaggugc cccucggggc uccucccccg     1860

uucccuaccu ggcccggcug uccccagccu cccccucugc augccuggca agccggaaca     1920

ccgcccccuc ccuccccuca gcccgcugcc uuuccgcagu cucugccuuu cccccagagc     1980

ccugcguuuc ccaccgcuuc cccugcuccc ccgcaaagcc cuggccuuca gccccucauc     2040

auccaccaug cccagauggu ucagcugggg cugaacaauc acauguggaa ccaacgggga     2100

ucucaggccc ccgaggacaa aacacaggaa gccgaguga                            2139


<210>  9417
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TICAM2__Homo_sapiens__Q86XR7

<400>  9417

Met Gly Ile Gly Lys Ser Lys Ile Asn Ser Cys Pro Leu Ser Leu Ser 
1               5                   10                  15      


Trp Gly Lys Arg His Ser Val Asp Thr Ser Pro Gly Tyr His Glu Ser 
            20                  25                  30          


Asp Ser Lys Lys Ser Glu Asp Leu Ser Leu Cys Asn Val Ala Glu His 
        35                  40                  45              


Ser Asn Thr Thr Glu Gly Pro Thr Gly Lys Gln Glu Gly Ala Gln Ser 
    50                  55                  60                  


Val Glu Glu Met Phe Glu Glu Glu Ala Glu Glu Glu Val Phe Leu Lys 
65                  70                  75                  80  


Phe Val Ile Leu His Ala Glu Asp Asp Thr Asp Glu Ala Leu Arg Val 
                85                  90                  95      


Gln Asn Leu Leu Gln Asp Asp Phe Gly Ile Lys Pro Gly Ile Ile Phe 
            100                 105                 110         


Ala Glu Met Pro Cys Gly Arg Gln His Leu Gln Asn Leu Asp Asp Ala 
        115                 120                 125             


Val Asn Gly Ser Ala Trp Thr Ile Leu Leu Leu Thr Glu Asn Phe Leu 
    130                 135                 140                 


Arg Asp Thr Trp Cys Asn Phe Gln Phe Tyr Thr Ser Leu Met Asn Ser 
145                 150                 155                 160 


Val Asn Arg Gln His Lys Tyr Asn Ser Val Ile Pro Met Arg Pro Leu 
                165                 170                 175     


Asn Asn Pro Leu Pro Arg Glu Arg Thr Pro Phe Ala Leu Gln Thr Ile 
            180                 185                 190         


Asn Ala Leu Glu Glu Glu Ser Arg Gly Phe Pro Thr Gln Val Glu Arg 
        195                 200                 205             


Ile Phe Gln Glu Ser Val Tyr Lys Thr Gln Gln Thr Ile Trp Lys Glu 
    210                 215                 220                 


Thr Arg Asn Met Val Gln Arg Gln Phe Ile Ala 
225                 230                 235 


<210>  9418
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TICAM2__Homo_sapiens__AAI09266

<400>  9418
auggguaucg ggaagucuaa aauaaauucc ugcccucuuu cucucucuug ggguaaaagg       60

cacagugugg auacaagucc aggauaucau gagucagauu ccaagaaguc ugaagaucua      120

uccuugugua auguugcuga gcacagcaau acaacagagg ggccaacagg aaagcaggag      180

ggagcucaga gcguggaaga gauguuugaa gaagaagcug aagaagaggu guuccucaaa      240

uuugugauau ugcaugcaga agaugacaca gaugaagccc ucagagucca gaaucugcua      300

caagaugacu uugguaucaa acccggaaua aucuuugcug agaugccaug uggcagacag      360

cauuuacaga auuuagauga ugcuguaaau gggucugcau ggacaaucuu auuacugacu      420

gaaaacuuuu uaagagauac uugguguaau uuccaguucu auacgucccu aaugaacucc      480

guuaacaggc agcauaaaua caacucuguu auacccaugc ggccccugaa caauccccuu      540

ccccgagaaa ggacucccuu ugcccuccaa accaucaaug ccuuagagga agaaagucgu      600

ggauuuccua cacaaguaga aagaauuuuu caggagucug uguauaagac acaacaaacu      660

auauggaaag agacaagaaa uaugguacaa agacaauuua uugccuga                   708


<210>  9419
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TICAM2__Homo_sapiens__AAI09266

<400>  9419
augggcaucg gcaagagcaa gaucaacucc ugcccccuga gccucuccug ggggaagcgc       60

cacagcgugg acaccucccc gggguaccac gagagcgacu ccaagaaguc cgaggaccug      120

agccugugca acgucgccga gcacagcaac accacggagg gccccaccgg gaagcaggag      180

ggcgcccagu ccguggagga gauguucgag gaggaggcgg aggaggaggu guuccucaag      240

uucgucaucc ugcacgccga ggacgacacc gacgaggccc ugcgggugca gaaccuccug      300

caggacgacu ucggcaucaa gcccgggauc aucuucgccg agaugcccug cggccgccag      360

caccuccaga accuggacga cgccgugaac gggagcgcgu ggaccauccu gcugcucacg      420

gagaacuucc ugcgggacac cuggugcaac uuccaguucu acaccucccu gaugaacagc      480

gucaaccgcc agcacaagua caacuccgug aucccgaugc ggccccucaa caacccccug      540

ccccgcgagc ggaccccguu cgcccugcag acgaucaacg cccucgagga ggagagccgc      600

ggcuucccca cccaggugga gcggaucuuc caggaguccg ucuacaagac ccagcagacc      660

aucuggaagg agacgcgcaa cauggugcag cggcaguuca ucgccuga                   708


<210>  9420
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TICAM2__Homo_sapiens__AAI09266

<400>  9420
augggcaucg gcaaguccaa gaucaacucc ugcccccucu cccucuccug gggcaagcgc       60

cacuccgucg acaccucccc cggcuaccac gaguccgacu ccaagaaguc cgaggaccuc      120

ucccucugca acgucgccga gcacuccaac accaccgagg gccccaccgg caagcaggag      180

ggcgcccagu ccgucgagga gauguucgag gaggaggccg aggaggaggu cuuccucaag      240

uucgucaucc uccacgccga ggacgacacc gacgaggccc uccgcgucca gaaccuccuc      300

caggacgacu ucggcaucaa gcccggcauc aucuucgccg agaugcccug cggccgccag      360

caccuccaga accucgacga cgccgucaac ggcuccgccu ggaccauccu ccuccucacc      420

gagaacuucc uccgcgacac cuggugcaac uuccaguucu acaccucccu caugaacucc      480

gucaaccgcc agcacaagua caacuccguc auccccaugc gcccccucaa caacccccuc      540

ccccgcgagc gcacccccuu cgcccuccag accaucaacg cccucgagga ggagucccgc      600

ggcuucccca cccaggucga gcgcaucuuc caggaguccg ucuacaagac ccagcagacc      660

aucuggaagg agacccgcaa caugguccag cgccaguuca ucgccuga                   708


<210>  9421
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TICAM2__Homo_sapiens__AAI09266

<400>  9421
augggcaucg gaaagagcaa aauuaacucc ugcccccugu cucucucaug ggggaagaga       60

cacagugugg acaccagccc ugguuaccau gaguccgauu cuaaaaaguc ggaagaccuu      120

ucacugugua augucgccga gcacagcaac acaacugaag gcccaacggg gaaacaggag      180

ggagcucaaa guguugaaga gauguucgag gaagaggcag aagaggaggu guuuuugaag      240

uucguaauau uacaugccga agaugacacc gaugaggcgc ugagggugca gaaucuacuc      300

caggacgauu uuggcaucaa gccggguauu aucuucgcug aaaugcccug cgggcggcag      360

caucugcaaa accuugacga ugccgucaau ggauccgcau ggacaauucu guugcucacu      420

gagaacuuuc ugcgcgacac cugguguaau uuccaguuuu auacaucucu gaugaacagc      480

gugaaucgac agcacaaaua caacuccguu aucccuaugc guccacucaa uaaccccuua      540

ccuagagaaa ggaccccauu cgcccugcag acuauaaaug cucuugagga ggaaucacgg      600

ggcuuuccca cacaagugga gcgcaucuuc caggaaagug ucuauaagac ccagcagacg      660

auuuggaaag agacuagaaa cauggugcaa aggcaguuua ucgcauga                   708


<210>  9422
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TICAM2__Homo_sapiens__AAI09266

<400>  9422
augggcaucg gcaagagcaa gaucaacagc ugcccccuga gccugagcug gggcaagaga       60

cacagcgugg acaccagccc cggcuaccac gagagcgaca gcaagaagag cgaggaccug      120

agccugugca acguggccga gcacagcaac accaccgagg gccccaccgg caagcaggag      180

ggcgcccaga gcguggagga gauguucgag gaggaggccg aggaggaggu guuccugaag      240

uucgugaucc ugcacgccga ggacgacacc gacgaggccc ugagagugca gaaccugcug      300

caggacgacu ucggcaucaa gcccggcauc aucuucgccg agaugcccug cggcagacag      360

caccugcaga accuggacga cgccgugaac ggcagcgccu ggaccauccu gcugcugacc      420

gagaacuucc ugagagacac cuggugcaac uuccaguucu acaccagccu gaugaacagc      480

gugaacagac agcacaagua caacagcgug auccccauga gaccccugaa caacccccug      540

cccagagaga gaacccccuu cgcccugcag accaucaacg cccuggagga ggagagcaga      600

ggcuucccca cccaggugga gagaaucuuc caggagagcg uguacaagac ccagcagacc      660

aucuggaagg agaccagaaa cauggugcag agacaguuca ucgccuga                   708


<210>  9423
<211>  708
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TICAM2__Homo_sapiens__AAI09266

<400>  9423
augggcaucg gaaagagcaa aauuaacucc ugcccccugu cucucagcug ggggaagaga       60

cacuccgugg acaccucucc uggcuaccau gagagcgauu ccaaaaaguc ugaagaccug      120

agccuuugua augucgccga gcacuccaac acaacggaag ggccgaccgg aaaacaggag      180

ggcgcucaaa gcguugaaga gauguucgag gaagaggccg aagaggaggu guuucugaag      240

uucgugaucc uccaugcgga agaugacaca gaugaggcuc ugcgggucca gaaucuucug      300

caggacgauu uugggauuaa gcccggaauc auuuucgccg aaaugccuug cggccgccag      360

caccuccaaa accuggacga ugccgugaau ggcucugcuu ggaccauccu gcuccugaca      420

gagaacuuuc uuagagacac cugguguaau uuccaguuuu auacaucccu gaugaacagc      480

guuaaucggc agcauaaaua caacucugug auccccaugc gcccucucaa uaacccccug      540

ccuagagaac ggaccccguu cgcccuucag acgauuaaug cucuggagga ggaaucccgc      600

ggguuuccca cccaagucga gagaaucuuc caggaaagcg uguauaagac acagcagacc      660

auuuggaaag agacacggaa caugguucaa cgccaguuua ucgccuga                   708


<210>  9424
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIRAP__Homo_sapiens__A0A024R3M4

<400>  9424

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


<210>  9425
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIRAP__Homo_sapiens__EAW67688

<400>  9425
auggcaucau cgaccucccu cccagcuccu ggcucucggc cuaagaagcc ucuaggcaag       60

auggcugacu gguucaggca gacccugcug aagaagccca agaagaggcc caacucccca      120

gaaagcaccu ccagcgaugc uucacagccu accucacagg acagcccacu acccccaagc      180

cucagcucag ucacgucucc cagccugcca cccacacaug cgagugacag uggcaguagu      240

cgcuggagca aagacuauga cgucugcgug ugccacagug aggaagaccu gguggccgcc      300

caggaccugg ucuccuacuu ggaaggcagc acugccagcc ugcgcugcuu ccugcaacuc      360

cgggaugcaa ccccaggcgg cgcuauagug uccgagcugu gccaggcacu gagcaguagu      420

cacugccggg ugcugcucau cacgccgggc uuccuucagg accccuggug caaguaccag      480

augcugcagg cccugaccga ggcuccaggg gccgagggcu gcaccauccc ccugcugucg      540

ggccucagca gagcugccua cccaccugag cuccgauuca uguacuacgu cgauggcagg      600

ggcccugaug guggcuuucg ucaagucaaa gaagcuguca ugcguuaucu gcagacacuc      660

aguuga                                                                 666


<210>  9426
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIRAP__Homo_sapiens__EAW67688

<400>  9426
auggccagcu ccaccagccu gcccgccccg ggcucccgcc ccaagaagcc ccucgggaag       60

auggcggacu gguuccggca gacccugcug aagaagccca agaagcgccc gaacagcccc      120

gaguccacga gcuccgacgc cagccagccc accucccagg acagcccccu cccgcccucc      180

cugagcuccg ugaccagccc cucccugccc ccgacccacg ccagcgacuc cggcagcucc      240

cgguggagca aggacuacga cgucugcgug ugccacagcg aggaggaccu cguggccgcc      300

caggaccugg ucuccuaccu ggaggggagc acggcguccc uccgcugcuu ccugcagcug      360

cgggacgcca cccccggcgg ggccaucgug agcgagcucu gccaggcccu guccagcucc      420

cacugccgcg ugcugcucau cacccccggc uuccugcagg accccuggug caaguaccag      480

augcugcagg cgcucaccga ggccccgggc gccgaggggu gcacgauccc ccugcugagc      540

ggccucuccc gggccgccua cccgcccgag cugcgcuuca uguacuacgu cgacgggcgg      600

ggccccgacg ggggcuuccg ccaggugaag gaggcgguga ugcgguaccu gcagacccuc      660

agcuga                                                                 666


<210>  9427
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIRAP__Homo_sapiens__EAW67688

<400>  9427
auggccuccu ccaccucccu ccccgccccc ggcucccgcc ccaagaagcc ccucggcaag       60

auggccgacu gguuccgcca gacccuccuc aagaagccca agaagcgccc caacuccccc      120

gaguccaccu ccuccgacgc cucccagccc accucccagg acuccccccu cccccccucc      180

cucuccuccg ucaccucccc cucccucccc cccacccacg ccuccgacuc cggcuccucc      240

cgcuggucca aggacuacga cgucugcguc ugccacuccg aggaggaccu cgucgccgcc      300

caggaccucg ucuccuaccu cgagggcucc accgccuccc uccgcugcuu ccuccagcuc      360

cgcgacgcca cccccggcgg cgccaucguc uccgagcucu gccaggcccu cuccuccucc      420

cacugccgcg uccuccucau cacccccggc uuccuccagg accccuggug caaguaccag      480

augcuccagg cccucaccga ggcccccggc gccgagggcu gcaccauccc ccuccucucc      540

ggccucuccc gcgccgccua cccccccgag cuccgcuuca uguacuacgu cgacggccgc      600

ggccccgacg gcggcuuccg ccaggucaag gaggccguca ugcgcuaccu ccagacccuc      660

uccuga                                                                 666


<210>  9428
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIRAP__Homo_sapiens__EAW67688

<400>  9428
auggccagcu ccaccucucu gcccgcuccu ggcucaagac caaagaaacc gcucgggaag       60

auggcagacu gguucaggca gacacuucug aaaaagccca aaaagcggcc uaacagucca      120

gagagcacuu ccucugaugc cucgcaaccc acgucacagg acagcccuuu gccacccagu      180

uuauccucug ugaccagccc uucccugcca ccgacacacg cgucagauag uggaagcucu      240

cgcuggucca aggacuacga ugucugcguu ugucauucag aagaggaccu aguggcugcc      300

caggaucucg uaagcuaucu ggaagguagu acugcaucuc uucgaugcuu ucugcaguug      360

cgugacgcca cccccggcgg ggcuaucgug uccgagcucu gucaagcacu gagcucgucu      420

cacugcagag uccugcucau uacaccugga uucuuacagg auccauggug uaaauaccag      480

augcugcagg cccuuaccga agcucccggc gccgaggguu gcacuauacc uuugcugucc      540

gggcuaucaa gggcggcaua uccacccgag cuccgguuua uguacuaugu ggacggacgc      600

ggcccggaug gcggguucag acaaguuaag gaagccguga ugagguaccu gcagacacuu      660

aguuga                                                                 666


<210>  9429
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIRAP__Homo_sapiens__EAW67688

<400>  9429
auggccagca gcaccagccu gcccgccccc ggcagcagac ccaagaagcc ccugggcaag       60

auggccgacu gguucagaca gacccugcug aagaagccca agaagagacc caacagcccc      120

gagagcacca gcagcgacgc cagccagccc accagccagg acagcccccu gccccccagc      180

cugagcagcg ugaccagccc cagccugccc cccacccacg ccagcgacag cggcagcagc      240

agauggagca aggacuacga cgugugcgug ugccacagcg aggaggaccu gguggccgcc      300

caggaccugg ugagcuaccu ggagggcagc accgccagcc ugagaugcuu ccugcagcug      360

agagacgcca cccccggcgg cgccaucgug agcgagcugu gccaggcccu gagcagcagc      420

cacugcagag ugcugcugau cacccccggc uuccugcagg accccuggug caaguaccag      480

augcugcagg cccugaccga ggcccccggc gccgagggcu gcaccauccc ccugcugagc      540

ggccugagca gagccgccua cccccccgag cugagauuca uguacuacgu ggacggcaga      600

ggccccgacg gcggcuucag acaggugaag gaggccguga ugagauaccu gcagacccug      660

agcuga                                                                 666


<210>  9430
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIRAP__Homo_sapiens__EAW67688

<400>  9430
auggccagcu ccaccucucu gcccgcuccu ggcagcagac cgaagaaacc ccucgggaag       60

auggccgacu gguuccggca gacacugcuu aaaaagccua aaaagcgccc caacuccccu      120

gagucuacga gcuccgaugc gucucaaccc accagccagg acuccccucu gccgcccagc      180

cucucuuccg ugacaagccc uucucugccc ccuacccacg cuuccgauag cggaucuucc      240

agauggagca aggacuacga ugucugcguu ugucauuccg aagaggaccu uguggccgcc      300

caggaucugg ugucuuaucu cgaaggcagc acagcuuccc ugcggugcuu ucugcagcuc      360

cgcgacgcca cccccggggg agcuaucguc agcgagcugu gucaagcccu uucuuccagc      420

cacugcagag ugcugcucau uacaccgggc uuccugcagg auccuuggug uaaauaccag      480

augcuucagg cgcugaccga agcccccggg gcugagggau gcacgauccc ucuccugucu      540

ggccugagcc gggccgcuua uccucccgag cuccgcuuua uguacuaugu ugacggcaga      600

gggcccgaug gaggcuuccg gcaagugaag gaagccguca ugcgcuaccu gcagacccuu      660

uccuga                                                                 666


<210>  9431
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TIRAP__Homo_sapiens__P58753

<400>  9431

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


<210>  9432
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TIRAP__Homo_sapiens__AAL05036

<400>  9432
auggcaucau cgaccucccu cccagcuccu ggcucucggc cuaagaagcc ucuaggcaag       60

auggcugacu gguucaggca gacccugcug aagaagccca agaagaggcc caacucccca      120

gaaagcaccu ccagcgaugc uucacagccu accucacagg acagcccacu acccccaagc      180

cucagcucag ucacgucucc cagccugcca cccacacaug cgagugacag uggcaguagu      240

cgcuggagca aagacuauga cgucugcgug ugccacagug aggaagaccu gguggccgcc      300

caggaccugg ucuccuacuu ggaaggcagc acugccagcc ugcgcugcuu ccugcaacuc      360

cgggaugcaa ccccaggcgg cgcuauagug uccgagcugu gccaggcacu gagcaguagu      420

cacugccggg ugcugcucau cacgccgggc uuccuucagg accccuggug caaguaccag      480

augcugcagg cccugaccga ggcuccaggg gccgagggcu gcaccauccc ccugcugucg      540

ggccucagca gagcugcuua cccaccugag cuccgauuca uguacuacgu cgauggcagg      600

ggcccugaug guggcuuucg ucaagucaaa gaagcuguca ugcguuaucu gcagacacuc      660

aguuga                                                                 666


<210>  9433
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TIRAP__Homo_sapiens__AAL05036

<400>  9433
auggccagcu ccaccagccu gcccgccccg ggcucccgcc ccaagaagcc ccucgggaag       60

auggcggacu gguuccggca gacccugcug aagaagccca agaagcgccc gaacagcccc      120

gaguccacga gcuccgacgc cagccagccc accucccagg acagcccccu cccgcccucc      180

cugagcuccg ugaccagccc cucccugccc ccgacccacg ccagcgacuc cggcagcucc      240

cgguggagca aggacuacga cgucugcgug ugccacagcg aggaggaccu cguggccgcc      300

caggaccugg ucuccuaccu ggaggggagc acggcguccc uccgcugcuu ccugcagcug      360

cgggacgcca cccccggcgg ggccaucgug agcgagcucu gccaggcccu guccagcucc      420

cacugccgcg ugcugcucau cacccccggc uuccugcagg accccuggug caaguaccag      480

augcugcagg cgcucaccga ggccccgggc gccgaggggu gcacgauccc ccugcugagc      540

ggccucuccc gggccgccua cccgcccgag cugcgcuuca uguacuacgu cgacgggcgg      600

ggccccgacg ggggcuuccg ccaggugaag gaggcgguga ugcgguaccu gcagacccuc      660

agcuga                                                                 666


<210>  9434
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TIRAP__Homo_sapiens__AAL05036

<400>  9434
auggccuccu ccaccucccu ccccgccccc ggcucccgcc ccaagaagcc ccucggcaag       60

auggccgacu gguuccgcca gacccuccuc aagaagccca agaagcgccc caacuccccc      120

gaguccaccu ccuccgacgc cucccagccc accucccagg acuccccccu cccccccucc      180

cucuccuccg ucaccucccc cucccucccc cccacccacg ccuccgacuc cggcuccucc      240

cgcuggucca aggacuacga cgucugcguc ugccacuccg aggaggaccu cgucgccgcc      300

caggaccucg ucuccuaccu cgagggcucc accgccuccc uccgcugcuu ccuccagcuc      360

cgcgacgcca cccccggcgg cgccaucguc uccgagcucu gccaggcccu cuccuccucc      420

cacugccgcg uccuccucau cacccccggc uuccuccagg accccuggug caaguaccag      480

augcuccagg cccucaccga ggcccccggc gccgagggcu gcaccauccc ccuccucucc      540

ggccucuccc gcgccgccua cccccccgag cuccgcuuca uguacuacgu cgacggccgc      600

ggccccgacg gcggcuuccg ccaggucaag gaggccguca ugcgcuaccu ccagacccuc      660

uccuga                                                                 666


<210>  9435
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TIRAP__Homo_sapiens__AAL05036

<400>  9435
auggccagcu ccaccucucu gcccgcuccu ggcucaagac caaagaaacc gcucgggaag       60

auggcagacu gguucaggca gacacuucug aaaaagccca aaaagcggcc uaacagucca      120

gagagcacuu ccucugaugc cucgcaaccc acgucacagg acagcccuuu gccacccagu      180

uuauccucug ugaccagccc uucccugcca ccgacacacg cgucagauag uggaagcucu      240

cgcuggucca aggacuacga ugucugcguu ugucauucag aagaggaccu aguggcugcc      300

caggaucucg uaagcuaucu ggaagguagu acugcaucuc uucgaugcuu ucugcaguug      360

cgugacgcca cccccggcgg ggcuaucgug uccgagcucu gucaagcacu gagcucgucu      420

cacugcagag uccugcucau uacaccugga uucuuacagg auccauggug uaaauaccag      480

augcugcagg cccuuaccga agcucccggc gccgaggguu gcacuauacc uuugcugucc      540

gggcuaucaa gggcggcaua uccacccgag cuccgguuua uguacuaugu ggacggacgc      600

ggcccggaug gcggguucag acaaguuaag gaagccguga ugagguaccu gcagacacuu      660

aguuga                                                                 666


<210>  9436
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TIRAP__Homo_sapiens__AAL05036

<400>  9436
auggccagca gcaccagccu gcccgccccc ggcagcagac ccaagaagcc ccugggcaag       60

auggccgacu gguucagaca gacccugcug aagaagccca agaagagacc caacagcccc      120

gagagcacca gcagcgacgc cagccagccc accagccagg acagcccccu gccccccagc      180

cugagcagcg ugaccagccc cagccugccc cccacccacg ccagcgacag cggcagcagc      240

agauggagca aggacuacga cgugugcgug ugccacagcg aggaggaccu gguggccgcc      300

caggaccugg ugagcuaccu ggagggcagc accgccagcc ugagaugcuu ccugcagcug      360

agagacgcca cccccggcgg cgccaucgug agcgagcugu gccaggcccu gagcagcagc      420

cacugcagag ugcugcugau cacccccggc uuccugcagg accccuggug caaguaccag      480

augcugcagg cccugaccga ggcccccggc gccgagggcu gcaccauccc ccugcugagc      540

ggccugagca gagccgccua cccccccgag cugagauuca uguacuacgu ggacggcaga      600

ggccccgacg gcggcuucag acaggugaag gaggccguga ugagauaccu gcagacccug      660

agcuga                                                                 666


<210>  9437
<211>  666
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TIRAP__Homo_sapiens__AAL05036

<400>  9437
auggccagcu ccaccucucu gcccgcuccu ggcagcagac cgaagaaacc ccucgggaag       60

auggccgacu gguuccggca gacacugcuu aaaaagccua aaaagcgccc caacuccccu      120

gagucuacga gcuccgaugc gucucaaccc accagccagg acuccccucu gccgcccagc      180

cucucuuccg ugacaagccc uucucugccc ccuacccacg cuuccgauag cggaucuucc      240

agauggagca aggacuacga ugucugcguu ugucauuccg aagaggaccu uguggccgcc      300

caggaucugg ugucuuaucu cgaaggcagc acagcuuccc ugcggugcuu ucugcagcuc      360

cgcgacgcca cccccggggg agcuaucguc agcgagcugu gucaagcccu uucuuccagc      420

cacugcagag ugcugcucau uacaccgggc uuccugcagg auccuuggug uaaauaccag      480

augcuucagg cgcugaccga agcccccggg gcugagggau gcacgauccc ucuccugucu      540

ggccugagcc gggccgcuua uccucccgag cuccgcuuua uguacuaugu ugacggcaga      600

gggcccgaug gaggcuuccg gcaagugaag gaagccguca ugcgcuaccu gcagacccuu      660

uccuga                                                                 666


<210>  9438
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__A0A024R9W4

<400>  9438

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9439
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__EAW92898

<400>  9439
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

aaugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cgaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacuauccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc auauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9440
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__EAW92898

<400>  9440
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu caacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

aacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gaccauccag cugccccacc ucaagacgcu gauccugaac     1140

ggcaacaagc ucgagacccu gucccuggug agcugcuucg ccaacaacac gccccucgag     1200

caccuggacc ugucccagaa ccuccugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccuguccuac aacaagcuca gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccuggaccuc aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugcgggag cucaacaucg ccuucaacuu ccugaccgac     1440

cugcccgggu gcucccacuu cagccgccuc uccguccuga acaucgagau gaacuucauc     1500

cugagcccgu cccucgacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcug aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccugcgg     1680

gggacccgcc ucaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcuggugcuc ggccuggccg uggccuucug cugccugcac     1800

uucgaccucc ccugguaccu gcgcaugcug gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcucaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcugaucc cgaaccucga gaaggaggac     1980

ggcuccaucc ugaucugccu guacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcucag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu gauccuccug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcugaaggc gcuccuggag aagaaggccu accuggagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu caacgugcug     2340

gcgacccggg agauguacga gcuccagacc uucacggagc ugaacgagga gagccgcggc     2400

uccaccauca gccugaugcg gaccgacugc cucuga                               2436


<210>  9441
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__EAW92898

<400>  9441
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

aacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg caccauccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9442
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__EAW92898

<400>  9442
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugagu ucaauaaaga acugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuuuaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

aaugccaaaa caucugugcu ucuguugaac aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcacacuucc guagaacauu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucacaau ucauuugacu acagcaacac agugaugcgc      900

accauuaaac uggagcaugu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaau cucacuauaa guaacgcaca gaugccucac     1020

augcuguucc caaauuaccc cacaaaguuu caauaucuua acuucgccaa uaacauccug     1080

accgaugagu uguuuaaaag aacuauucag cucccucauc ugaagacauu aauccugaau     1140

ggcaacaaac uagagacccu cucucuggug uccugcuucg cuaauaacac gccacuugaa     1200

cacuuggacc ugagccagaa ucuccugcaa cauaagaacg augagaauug uucguggccg     1260

gaaaccgucg uuaacaugaa cuuaucuuac aauaagcugu ccgacucagu guuuaggugc     1320

cuucccaaaa guauacagau uuuggaucuc aacaauaacc agauccagac aguaccuaag     1380

gagacuaucc accugauggc ccuacgggaa cugaauauug cguucaacuu ucucaccgac     1440

cugccaggcu guagccauuu cucccgucuu ucuguguuga auaucgagau gaacuuuauu     1500

cugagccccu cauuagauuu cguccaaagu ugccaggagg ugaaaacacu caaugcaggg     1560

cgcaacccuu ucagauguac uugcgaacug aagaauuuua uacagcuuga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccacu gaacuugagg     1680

gguacccggc ucaaagacgu ccaucugcac gaacuaucau gcaauacugc ccugcucauc     1740

gugacgauug uaguuaucau gcuggugcuu ggcuuggcug ucgccuucug cugucugcac     1800

uuugauuuac ccugguaccu ccgaaugcug gggcagugca cacaaaccug gcaccgcgug     1860

agaaagacua cccaggagca gcuuaagagg aacguccggu uccaugcauu uaucaguuac     1920

agcgagcacg acucccugug ggugaaaaau gaacuaauuc cgaaccucga gaaggaagau     1980

ggaucuauac ugaucuguuu guaugagucg uacuucgacc cuggcaaaag cauuuccgag     2040

aacaucguuu cauuuauuga aaagaguuau aaaucuaucu ucgugcugag ccccaauuuu     2100

guacagaacg aguggugcca cuacgaguuc uauuuugcuc aucacaauuu auuccaugaa     2160

aacuccgauc acauaauccu cauucugcuu gaaccaaucc cuuuuuacug uauucccaca     2220

cgcuaucaua agcugaaggc cuugcucgag aaaaaggcgu accuggagug gccaaaagac     2280

agaaggaagu gcggucuauu cugggccaau cugcgugcag cuaucaacgu caaugugcuu     2340

gccacccggg aaauguacga gcuccaaacu uucacagaac ugaacgagga aucacgaggg     2400

agcacgauau cuuugaugag aaccgauugu cuguga                               2436


<210>  9443
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__EAW92898

<400>  9443
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

aacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aaccauccag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9444
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__EAW92898

<400>  9444
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga acugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

aaugccaaaa cguccguccu ucugcucaac aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcacacaagc guggaacauu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucacaau uccuuugacu acucuaacac agugaugcgg      900

accauuaaac ucgagcaugu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaau cucacaauua gcaacgccca gaugccucac     1020

augcuguucc cgaauuaccc cacgaaguuu caauaucuga acuucgcgaa uaacauccuc     1080

accgaugagc uguuuaaaag aacaauccag cuuccucauc ugaagacccu cauucugaau     1140

gggaacaaac uggagacacu uucccucguu agcugcuucg ccaauaacac gccccuggaa     1200

caccuggacc ucucucagaa ucugcuucaa cauaagaacg augagaauug uuccuggccu     1260

gaaaccgugg ugaacaugaa ccugagcuac aauaagcucu cugacagcgu cuuucggugc     1320

cugcccaaau ccauccagau ucuggaucuu aacaauaacc agauccagac agugccgaag     1380

gagaccauuc accucauggc ucugcgcgaa cugaauaucg ccuucaacuu ucucaccgac     1440

cugccuggau guucucauuu cagcagacuu uccguucuga auaucgagau gaacuuuauu     1500

cucagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacacu gaaugcuggc     1560

cggaacccuu ucagauguac cugcgaacuu aagaauuuua uccagcucga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu gaaccugcgc     1680

ggaacccggc ucaaagacgu gcaccuucac gaacuuagcu gcaauacagc ccugcucauu     1740

gucaccaucg uggucauuau gcuggugcug ggccuugcgg uugccuucug cugucugcau     1800

uuugaucucc ccugguaccu gagaaugcuc gggcagugca cacaaaccug gcaccgcgug     1860

cggaagacga cccaggagca gcugaagaga aacguccgcu uccaugcuuu uaucuccuac     1920

ucugagcacg acagccuuug ggugaaaaau gaacugauuc cuaaccucga gaaggaagau     1980

ggauccaucc ugaucugucu guaugagucu uacuucgacc cgggcaaaag cauuuccgag     2040

aacaucguua gcuuuauuga aaagucuuau aaauccaucu ucgugcuuag ccccaauuuu     2100

guccagaacg aguggugcca cuacgaguuc uauuuugccc aucacaaucu guuccaugaa     2160

aacucugauc acauuauccu cauccugcuc gaaccuauuc ccuuuuacug uaucccuaca     2220

cgguaucaua agcugaaggc ucugcuggag aaaaaggccu accucgagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaau cugcgggcug cgauuaacgu gaaugugcuu     2340

gccaccagag aaauguacga gcugcaaaca uucaccgaac ucaacgagga aucccgcggg     2400

agcacgaucu cucugaugcg gacagauugu cucuga                               2436


<210>  9445
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS19

<400>  9445

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9446
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78477

<400>  9446
augagacuca ucagaaacau uuacauauuu uguaguauag uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

caugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaagu uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cgaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc auauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9447
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78477

<400>  9447
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

cacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gacccugcag cucccccacc ugaagacgcu gauccucaac     1140

ggcaacaagc uggagacccu gucccucgug agcugcuucg ccaacaacac gccccuggag     1200

caccuggacc ucucccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccucuccuac aacaagcuga gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaucg ccuucaacuu ccugaccgac     1440

cuccccgggu gcucccacuu cagccgccug uccguccuga acaucgagau gaacuucauc     1500

cucagcccgu cccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcucgugcug ggccuggccg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcugaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcuccaucc ugaucugccu cuacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc gcugcuggag aagaaggccu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu caacgugcuc     2340

gcgacccggg agauguacga gcugcagacc uucacggagc ugaacgagga gagccgcggc     2400

uccaccauca gccucaugcg gaccgacugc cuguga                               2436


<210>  9448
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78477

<400>  9448
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

cacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9449
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78477

<400>  9449
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugaau uuaauaaaga gcugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuucaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

cacgccaaaa caucugugcu ucuguugaau aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcauacuucc guagaacacu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucauaac ucauuugacu acagcaauac agugaugcgc      900

accauuaaac uggagcacgu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaac cucacuauaa guaaugcaca gaugccucau     1020

augcuguucc caaacuaccc cacaaaguuu caauaucuua auuucgccaa caauauccug     1080

accgaugagu uguuuaaaag aacucuccag cugccucacu uaaagacacu gauucuaaac     1140

ggcaauaaac ucgagacccu gucucuugug uccugcuucg cuaacaauac gccauuggaa     1200

caucuggacc ucagccagaa ccuguuacaa cacaagaaug augagaacug uucguggccg     1260

gaaaccgucg uuaauaugaa ccugucuuac aacaaacuuu ccgacucagu guuuaggugc     1320

uugcccaaga guauccagau acucgaucug aauaacaauc agauucagac aguaccuaag     1380

gagacuaucc aucuaauggc ccugcgggaa cucaacaucg cguucaauuu ucugaccgac     1440

cuuccaggcu guagccacuu cucccguuug ucugugcuga acauugagau gaauuuuauc     1500

uuaagccccu cacucgauuu cguccaaagu ugccaggagg ugaaaacacu gaacgcaggg     1560

cgcaauccuu ucagauguac uugcgaacuu aagaacuuua uucagcugga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccauu gaaucucagg     1680

gguacccggc ugaaagacgu ccaccuacau gaacugucau gcaacacugc ccuccugaua     1740

gugacgaucg uaguuauuau gcuuguguug ggccuggcug ucgccuucug cuguuuacac     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cacaaaccug gcaucgcgug     1860

agaaagacua cccaggagca gcugaagagg aauguccggu uccacgcauu uaucaguuac     1920

agcgagcacg acucccuaug ggugaaaaac gaacucaucc cgaaucugga gaaggaagau     1980

ggaucuauuu ugauaugucu guaugagucg uacuucgacc cuggcaaaag caucuccgag     2040

aacauuguuu cauuuaucga aaagaguuau aaaucuauuu ucguguuaag ccccaacuuu     2100

guacagaaug aguggugcca uuacgaguuc uauuuugcuc accauaaccu cuuccacgaa     2160

aauuccgauc auaucauacu gauccuucug gaaccaauuc cuuuuuacug uauccccaca     2220

cgcuaucaca aguugaaggc ccuccuggag aaaaaggcgu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggccaac cuucgugcag cuauuaaugu caacgugcuc     2340

gccacccggg aaauguacga gcugcaaacu uucacagaau ugaaugagga aucacgaggg     2400

agcacgaucu cucugaugag aaccgauugu uuauga                               2436


<210>  9450
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78477

<400>  9450
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

cacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9451
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78477

<400>  9451
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga gcugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

cacgccaaaa cguccguccu ucugcucaau aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcauacaagc guggaacacu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucauaac uccuuugacu acucuaauac agugaugcgg      900

accauuaaac ucgagcacgu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaac cucacaauua gcaaugccca gaugccucau     1020

augcuguucc cgaacuaccc cacgaaguuu caauaucuga auuucgcgaa caauauccuc     1080

accgaugagc uguuuaaaag aacacuucag cugccucacc ucaagacccu gauccugaac     1140

gggaauaaac uugagacacu cucccugguu agcugcuucg ccaacaauac gccccuggaa     1200

caucucgacc ugucucagaa ccuucugcaa cacaagaaug augagaacug uuccuggccu     1260

gaaaccgugg ugaauaugaa ccucagcuac aacaagcugu cugacagcgu cuuucggugc     1320

cugcccaaau ccauucagau ccuugaucuc aauaacaauc agauucagac agugccgaag     1380

gagaccaucc aucugauggc ucugcgcgaa cucaacauug ccuucaauuu ucugaccgac     1440

cuuccuggau guucucacuu cagcagacug uccguucuca acaucgagau gaauuuuauc     1500

cugagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacacu uaacgcuggc     1560

cggaauccuu ucagauguac cugcgaacuc aagaacuuua uucagcugga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu gaaucuccgc     1680

ggaacccggc ugaaagacgu gcaccuucau gaacugagcu gcaacacagc ccuccugauc     1740

gucaccauug uggucaucau gcuggugcuu ggccuggcgg uugccuucug cugucuccac     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cacaaaccug gcaucgcgug     1860

cggaagacga cccaggagca gcuuaagaga aauguccgcu uccacgcuuu uauuuccuac     1920

ucugagcacg acagccugug ggugaaaaac gaacucaucc cuaaucugga gaaggaagau     1980

ggauccauuc ugaucugucu uuaugagucu uacuucgacc cgggcaaaag caucuccgag     2040

aacauuguua gcuuuaucga aaagucuuau aaauccauuu ucgugcugag ccccaacuuu     2100

guccagaaug aguggugcca uuacgaguuc uauuuugccc accauaaccu cuuccacgaa     2160

aauucugauc auaucauucu gauccuccug gaaccuaucc ccuuuuacug uauuccuaca     2220

cgguaucaca aacuuaaggc ucugcucgaa aagaaggccu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaac cuucgggcug cgaucaaugu gaacgugcug     2340

gccaccagag aaauguacga gcuccaaaca uucaccgaac ugaaugagga aucccgcggg     2400

agcacgauuu cucucaugcg gacagauugu cuguga                               2436


<210>  9452
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS20

<400>  9452

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ser His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Thr Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9453
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78478

<400>  9453
augagacuca ucagaaacau uuacauauuu uguaguauag uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acaacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauuucuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

aaugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaacgga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cuaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc acauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagacugu cuauaa                               2436


<210>  9454
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78478

<400>  9454
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucagcc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggcu cccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacga gcaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gucccuggag      720

aacgcgaaga ccagcgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac uccuucgacu acagcaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagacgga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccuc     1080

accgacgagc uguucaagcg gacgcugcag cucccccacc ugaagacccu gauccucaac     1140

ggcaacaagc uggagacccu gagccucgug uccugcuucg cgaacaacac gccccuggag     1200

caccuggacc ucagccagaa ccugcugcag cacaagaacg acgagaacug cuccuggccg     1260

gagaccgugg ucaacaugaa ccucagcuac aacaagcugu ccgacagcgu guuccgcugc     1320

cugcccaagu ccauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaucg ccuucaacuu ccugaccgac     1440

cuccccgggu gcagccacuu cucccgccug agcguccuga acaucgagau gaacuucauc     1500

cucuccccga gccuggacuu cgugcagucc ugccaggagg ugaagacgcu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacagc     1620

gaggucauga uggugggcug guccgacagc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu ccaccuccac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggucaucau gcucgugcug ggccuggcgg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cccaggagca gcugaagcgg aacgugcgcu uccacgccuu caucuccuac     1920

agcgagcacg acucccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu cuacgagucc uacuucgacc ccggcaagag caucuccgag     2040

aacaucguca gcuucaucga gaaguccuac aagagcaucu ucgugcuguc ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc ccugcuggag aagaaggcgu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu caacgugcuc     2340

gccacccggg agauguacga gcugcagacg uucaccgagc ugaacgagga gucccgcggc     2400

agcaccaucu cccucaugcg gaccgacugc cuguga                               2436


<210>  9455
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78478

<400>  9455
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucuccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

aacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaccga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9456
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78478

<400>  9456
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugagu ucaauaaaga acugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuuuaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucagcc auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggau cccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu caaaaauccu ggagaugacc      660

aauauagacg guaagaguca guuuguuagc uacgaaaugc agaggaaccu cucucuggag      720

aaugcaaaaa cauccgugcu ucuguugaac aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcacacuuca guagaacauu uccaaauccg gaacguuacc      840

uucgggggaa aggccuaucu cgaucacaau agcuuugacu acaguaacac agugaugcgc      900

accauuaaac uggagcaugu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaacuga cauugaaaau cucacaauau cuaacgcuca gaugccucac     1020

augcuguucc caaauuaccc caccaaguuu caauaucuua acuucgcaaa uaacauccug     1080

acugaugagu uguuuaaaag aacacuccag cugccucauu uaaagacccu gauucuaaau     1140

ggcaacaaac ucgagacgcu gucccuugug agcugcuucg ccaauaacac cccauuggaa     1200

caccuggacc ucucgcagaa ucuguuacaa cauaagaacg augagaauug uucuuggccg     1260

gaaacagucg uuaacaugaa ccuguccuac aauaaacuuu cagacagugu guuuaggugc     1320

uugcccaaga gcauccagau acucgaucug aacaauaacc agauucagac uguaccuaag     1380

gagaccaucc accuaauggc ucugcgggaa cucaauaucg ccuucaacuu ucugacagac     1440

cuuccaggcu guucccauuu cucucguuug agcgugcuga auauugagau gaacuuuauc     1500

uuaucaccca gucucgauuu cguccaaucc ugccaggagg ugaaaacucu gaaugcgggg     1560

cgcaacccuu ucagauguac cugcgaacuu aagaauuuua uucagcugga gacauauagc     1620

gaaguuauga uggugggaug gucugacuca uacaccugug aguauccauu gaaccucagg     1680

gguacucggc ugaaagacgu ccaccuacac gaacugaguu gcaauacggc acuccugaua     1740

gugacaaucg uaguuauuau gcuuguguug ggccuggccg ucgcuuucug cuguuuacau     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cccaaacuug gcaccgcgug     1860

agaaagacca cacaggagca gcugaagagg aacguccggu uccaugccuu uaucagcuac     1920

uccgagcacg acucucuaug ggugaaaaau gaacucaucc cgaaccugga gaaggaagau     1980

ggaucgauuu ugauaugucu guaugagagc uacuucgacc cuggcaaauc caucucagag     2040

aacauuguua guuuuaucga aaagucuuau aaaagcauuu ucguguuauc ccccaauuuu     2100

guacagaacg aguggugcca cuacgaguuc uauuuugcac aucacaaucu cuuccaugaa     2160

aacucagauc acaucauacu gauccuucug gaaccaauuc cuuuuuacug uauccccacc     2220

cgcuaucaua aguugaaggc ucuccuggag aaaaaggccu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggcgaau cuucgugccg caauuaacgu caaugugcuc     2340

gcuacucggg aaauguacga gcugcaaaca uucacggaau ugaacgagga aagccgaggg     2400

ucuaccaucu cccugaugag aacugauugu uuauga                               2436


<210>  9457
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78478

<400>  9457
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucagcc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

aacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaccga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9458
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78478

<400>  9458
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga acugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucagcc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggcu cucucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau ccaaaauccu ggagaugacc      660

aauauugacg gaaagagcca guuugugucu uacgaaaugc agcgcaaccu cucccuggag      720

aaugcuaaaa cgagcguccu ucugcucaac aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcacacaucc guggaacauu uccaaaucag aaacgucacc      840

uucggcggca aggccuaucu ggaucacaau ucuuuugacu acagcaacac agugaugcgg      900

accauuaaac ucgagcaugu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaacaga caucgaaaau cucacgauuu ccaacgcuca gaugccucac     1020

augcuguucc cgaauuaccc caccaaguuu caauaucuga acuucgccaa uaacauccuc     1080

acagaugagc uguuuaaaag aacccuucag cugccucauc ucaagacacu gauccugaau     1140

gggaacaaac uugagacccu cagccugguu ucuugcuucg cgaauaacac gccccuggaa     1200

caccucgacc ugucccagaa ucuucugcaa cauaagaacg augagaauug uagcuggccu     1260

gaaacagugg ugaacaugaa ccucucuuac aauaagcuga gcgacuccgu cuuucggugc     1320

cugcccaaau cuauucagau ccuugaucuc aacaauaacc agauucagac cgugccgaag     1380

gagaccaucc accugauggc ccugcgcgaa cucaauauug cuuucaacuu ucugacagac     1440

cuuccuggau guagccauuu cuccagacug agcguucuca auaucgagau gaacuuuauc     1500

cugucucccu cccuggauuu cgugcaaagc ugccaggagg ucaaaacccu uaaugccggc     1560

cggaacccuu ucagauguac augcgaacuc aagaauuuua uucagcugga gacguauucu     1620

gaagugauga ugguugggug guccgacagc uacaccugug aguauccccu gaaccuccgc     1680

ggaacacggc ugaaagacgu gcaccuucac gaacuguccu gcaauaccgc ucuccugauc     1740

gucacaauug uggucaucau gcuggugcuu ggccuggccg uugcguucug cugucuccau     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cccaaacgug gcaccgcgug     1860

cggaagacca cacaggagca gcuuaagaga aacguccgcu uccaugccuu uauuucuuac     1920

agcgagcacg acucccugug ggugaaaaau gaacucaucc cuaaccugga gaaggaagau     1980

ggaucuauuc ugaucugucu uuaugagagc uacuucgacc cgggcaaauc caucagcgag     2040

aacauuguuu cuuuuaucga aaaguccuau aaaagcauuu ucgugcuguc ucccaauuuu     2100

guccagaacg aguggugcca cuacgaguuc uauuuugcuc aucacaaucu cuuccaugaa     2160

aacuccgauc acaucauucu gauccuccug gaaccuaucc ccuuuuacug uauuccuacc     2220

cgguaucaua aacuuaaggc ccugcucgag aagaaggcuu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaau cuucgggccg cuaucaacgu gaaugugcug     2340

gcgacaagag aaauguacga gcuccaaacc uucacggaac ugaacgagga aagccgcggg     2400

ucuacaauua gccucaugcg gaccgauugu cuguga                               2436


<210>  9459
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS24

<400>  9459

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Val Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9460
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78482

<400>  9460
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

caugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cuaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc acauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuguuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9461
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78482

<400>  9461
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

cacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gacccugcag cucccccacc ugaagacgcu gauccucaac     1140

ggcaacaagc uggagacccu gucccucgug agcugcuucg ccaacaacac gccccuggag     1200

caccuggacc ucucccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccucuccuac aacaagcuga gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaucg ccuucaacuu ccugaccgac     1440

cuccccgggu gcucccacuu cagccgccug uccguccuga acaucgagau gaacuucauc     1500

cucagcccgu cccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcucgugcug ggccuggccg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcugaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcuccaucc ugaucugccu cuacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc gcugcuggag aagaaggccu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccgucaacgu gaacgugcuc     2340

gcgacccggg agauguacga gcugcagacc uucacggagc ugaacgagga gagccgcggc     2400

uccaccauca gccucaugcg gaccgacugc cuguga                               2436


<210>  9462
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78482

<400>  9462
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

cacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccgucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9463
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78482

<400>  9463
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugaau uuaauaaaga gcugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuucaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

cacgccaaaa caucugugcu ucuguugaau aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcauacuucc guagaacacu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucauaac ucauuugacu acagcaauac agugaugcgc      900

accauuaaac uggagcacgu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaac cucacuauaa guaaugcaca gaugccucau     1020

augcuguucc caaacuaccc cacaaaguuu caauaucuua auuucgccaa caauauccug     1080

accgaugagu uguuuaaaag aacucuccag cugccucacu uaaagacacu gauucuaaac     1140

ggcaauaaac ucgagacccu gucucuugug uccugcuucg cuaacaauac gccauuggaa     1200

caucuggacc ucagccagaa ccuguuacaa cacaagaaug augagaacug uucguggccg     1260

gaaaccgucg uuaauaugaa ccugucuuac aacaaacuuu ccgacucagu guuuaggugc     1320

uugcccaaga guauccagau acucgaucug aauaacaauc agauucagac aguaccuaag     1380

gagacuaucc aucuaauggc ccugcgggaa cucaacaucg cguucaauuu ucugaccgac     1440

cuuccaggcu guagccacuu cucccguuug ucugugcuga acauugagau gaauuuuauc     1500

uuaagccccu cacucgauuu cguccaaagu ugccaggagg ugaaaacacu gaacgcaggg     1560

cgcaauccuu ucagauguac uugcgaacuu aagaacuuua uucagcugga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccauu gaaucucagg     1680

gguacccggc ugaaagacgu ccaccuacau gaacugucau gcaacacugc ccuccugaua     1740

gugacgaucg uaguuauuau gcuuguguug ggccuggcug ucgccuucug cuguuuacac     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cacaaaccug gcaucgcgug     1860

agaaagacua cccaggagca gcugaagagg aauguccggu uccacgcauu uaucaguuac     1920

agcgagcacg acucccuaug ggugaaaaac gaacucaucc cgaaucugga gaaggaagau     1980

ggaucuauuu ugauaugucu guaugagucg uacuucgacc cuggcaaaag caucuccgag     2040

aacauuguuu cauuuaucga aaagaguuau aaaucuauuu ucguguuaag ccccaacuuu     2100

guacagaaug aguggugcca uuacgaguuc uauuuugcuc accauaaccu cuuccacgaa     2160

aauuccgauc auaucauacu gauccuucug gaaccaauuc cuuuuuacug uauccccaca     2220

cgcuaucaca aguugaaggc ccuccuggag aaaaaggcgu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggccaac cuucgugcag cugucaaugu gaacguucuc     2340

gccacccggg aaauguacga gcugcaaacu uucacagaau ugaaugagga aucacgaggg     2400

agcacgauuu cucugaugag aaccgauugu uuauga                               2436


<210>  9464
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78482

<400>  9464
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

cacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccgugaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9465
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78482

<400>  9465
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga gcugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

cacgccaaaa cguccguccu ucugcucaau aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcauacaagc guggaacacu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucauaac uccuuugacu acucuaauac agugaugcgg      900

accauuaaac ucgagcacgu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaac cucacaauua gcaaugccca gaugccucau     1020

augcuguucc cgaacuaccc cacgaaguuu caauaucuga auuucgcgaa caauauccuc     1080

accgaugagc uguuuaaaag aacacuucag cugccucacc ucaagacccu gauccugaac     1140

gggaauaaac uugagacacu cucccugguu agcugcuucg ccaacaauac gccccuggaa     1200

caucucgacc ugucucagaa ccuucugcaa cacaagaaug augagaacug uuccuggccu     1260

gaaaccgugg ugaauaugaa ccucagcuac aacaagcugu cugacagcgu cuuucggugc     1320

cugcccaaau ccauucagau ccuugaucuc aauaacaauc agauucagac agugccgaag     1380

gagaccaucc aucugauggc ucugcgcgaa cucaacauug ccuucaauuu ucugaccgac     1440

cuuccuggau guucucacuu cagcagacug uccguucuca acaucgagau gaauuuuauc     1500

cugagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacacu uaacgcuggc     1560

cggaauccuu ucagauguac cugcgaacuc aagaacuuua uucagcugga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu gaaucuccgc     1680

ggaacccggc ugaaagacgu gcaccuucau gaacugagcu gcaacacagc ccuccugauc     1740

gucaccauug uggucaucau gcuggugcuu ggccuggcgg uugccuucug cugucuccac     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cacaaaccug gcaucgcgug     1860

cggaagacga cccaggagca gcuuaagaga aauguccgcu uccacgcuuu uauuuccuac     1920

ucugagcacg acagccugug ggugaaaaac gaacucaucc cuaaucugga gaaggaagau     1980

ggauccauuc ugaucugucu uuaugagucu uacuucgacc cgggcaaaag caucuccgag     2040

aacauuguua gcuuuaucga aaagucuuau aaauccauuu ucgugcugag ccccaacuuu     2100

guccagaaug aguggugcca uuacgaguuc uauuuugccc accauaaccu cuuccacgaa     2160

aauucugauc auaucauucu gauccuccug gaaccuaucc ccuuuuacug uauuccuaca     2220

cgguaucaca aacuuaaggc ucugcucgaa aagaaggccu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaac cuucgggcug cggugaaugu gaacguucug     2340

gccaccagag aaauguacga gcuccaaaca uucaccgaac ugaaugagga aucccgcggg     2400

agcacgaucu cucucaugcg gacagauugu cuguga                               2436


<210>  9466
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS26

<400>  9466

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Thr Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Val Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9467
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78484

<400>  9467
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

caugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cuaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauacug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc acauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuguuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagacugu cuauaa                               2436


<210>  9468
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78484

<400>  9468
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

cacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gacccugcag cucccccacc ugaagacgcu gauccucaac     1140

ggcaacaagc uggagacccu gucccucgug agcugcuucg ccaacaacac gccccuggag     1200

caccuggacc ucucccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccucuccuac aacaagcuga gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaccg ccuucaacuu ccugaccgac     1440

cuccccgggu gcucccacuu cagccgccug uccguccuga acaucgagau gaacuucauc     1500

cucagcccgu cccuggacuu cgugcagagc ugccaggagg ugaagacgcu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcucgugcug ggccuggccg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cccaggagca gcugaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcuccaucc ugaucugccu cuacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc gcugcuggag aagaaggccu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccgucaacgu gaacgugcuc     2340

gcgacccggg agauguacga gcugcagacg uucaccgagc ugaacgagga gagccgcggc     2400

uccaccauca gccucaugcg gaccgacugc cuguga                               2436


<210>  9469
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78484

<400>  9469
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

cacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaccg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccgucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9470
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78484

<400>  9470
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugaau uuaauaaaga gcugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuucaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

cacgccaaaa caucugugcu ucuguugaau aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcauacuucc guagaacacu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucauaac ucauuugacu acagcaauac agugaugcgc      900

accauuaaac uggagcacgu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaac cucacuauaa guaaugcaca gaugccucau     1020

augcuguucc caaacuaccc cacaaaguuu caauaucuua auuucgccaa caauauccug     1080

accgaugagu uguuuaaaag aacucuccag cugccucacu uaaagacacu gauucuaaac     1140

ggcaauaaac ucgagacccu gucucuugug uccugcuucg cuaacaauac gccauuggaa     1200

caucuggacc ucagccagaa ccuguuacaa cacaagaaug augagaacug uucguggccg     1260

gaaaccgucg uuaauaugaa ccugucuuac aacaaacuuu ccgacucagu guuuaggugc     1320

uugcccaaga guauccagau acucgaucug aauaacaauc agauucagac aguaccuaag     1380

gagacuaucc aucuaauggc ccugcgggaa cucaacaccg cguucaauuu ucugacagac     1440

cuuccaggcu guagccacuu cucccguuug ucugugcuga acaucgagau gaauuuuauu     1500

uuaagccccu cacucgauuu cguccaaagu ugccaggagg ugaaaacucu gaacgcaggg     1560

cgcaauccuu ucagauguac cugcgaacuu aagaacuuua uccagcugga gacauauucc     1620

gaaguuauga uggugggaug gagcgacucu uacaccugug aguauccauu gaaucucagg     1680

gguacucggc ugaaagacgu ccaccuacau gaacugucau gcaacacggc ccuccugauu     1740

gugacaauag uaguuaucau gcuuguguug ggccuggcug ucgccuucug cuguuuacac     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cccaaacuug gcaucgcgug     1860

agaaagacca cacaggagca gcugaagagg aauguccggu uccacgcauu uauuaguuac     1920

agcgagcacg acucccuaug ggugaaaaac gaacucaucc cgaaucugga gaaggaagau     1980

ggaucuaucu ugauuugucu guaugagucg uacuucgacc cuggcaaaag cauauccgag     2040

aacaucguuu cauuuauuga aaagaguuau aaaucuaucu ucguguuaag ccccaacuuu     2100

guacagaaug aguggugcca uuacgaguuc uauuuugcuc accauaaccu cuuccacgaa     2160

aauuccgauc auauuauccu gauacuucug gaaccaaucc cuuuuuacug uauucccacc     2220

cgcuaucaca aguugaaggc ccuccuggag aaaaaggcgu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggccaac cuucgugcag cugucaaugu gaacguucuc     2340

gccacucggg aaauguacga gcugcaaaca uucacggaau ugaaugagga aucacgaggg     2400

agcaccaucu cucugaugag aacugauugu uuauga                               2436


<210>  9471
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78484

<400>  9471
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

cacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaccg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccgugaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9472
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78484

<400>  9472
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga gcugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

cacgccaaaa cguccguccu ucugcucaau aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcauacaagc guggaacacu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucauaac uccuuugacu acucuaauac agugaugcgg      900

accauuaaac ucgagcacgu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaac cucacaauua gcaaugccca gaugccucau     1020

augcuguucc cgaacuaccc cacgaaguuu caauaucuga auuucgcgaa caauauccuc     1080

accgaugagc uguuuaaaag aacacuucag cugccucacc ucaagacccu gauccugaac     1140

gggaauaaac uugagacacu cucccugguu agcugcuucg ccaacaauac gccccuggaa     1200

caucucgacc ugucucagaa ccuucugcaa cacaagaaug augagaacug uuccuggccu     1260

gaaaccgugg ugaauaugaa ccucagcuac aacaagcugu cugacagcgu cuuucggugc     1320

cugcccaaau ccauucagau ccuugaucuc aauaacaauc agauucagac agugccgaag     1380

gagaccaucc aucugauggc ucugcgcgaa cucaacaccg ccuucaauuu ucugacagac     1440

cuuccuggau guucucacuu cagcagacug uccguucuca acauugagau gaauuuuauc     1500

cugagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacccu uaacgcuggc     1560

cggaauccuu ucagauguac augcgaacuc aagaacuuua uccagcugga gacguauagc     1620

gaagugauga ugguugggug gucugacucc uacaccugug aguauccccu gaaucuccgc     1680

ggaacacggc ugaaagacgu gcaccuucau gaacugagcu gcaacaccgc ccuccugauu     1740

gucacaaucg uggucauuau gcuggugcuu ggccuggcgg uugccuucug cugucuccac     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cccaaacgug gcaucgcgug     1860

cggaagacca cacaggagca gcuuaagaga aauguccgcu uccacgcuuu uaucuccuac     1920

ucugagcacg acagccugug ggugaaaaac gaacucauuc cuaaucugga gaaggaagau     1980

ggauccaucc ugauuugucu uuaugagucu uacuucgacc cgggcaaaag caucuccgag     2040

aacaucguua gcuuuauuga aaagucuuau aaauccaucu ucgugcugag ccccaacuuu     2100

guccagaaug aguggugcca uuacgaguuc uauuuugccc accauaaccu cuuccacgaa     2160

aauucugauc auauuauccu gauucuccug gaaccuaucc ccuuuuacug uaucccuacc     2220

cgguaucaca aacuuaaggc ucugcucgaa aagaaggccu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaac cuucgggcug cggugaaugu gaacguucug     2340

gccacaagag aaauguacga gcuccaaacc uucacggaac ugaaugagga aucccgcggg     2400

agcacaauuu cucucaugcg gaccgauugu cuguga                               2436


<210>  9473
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS27

<400>  9473

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Ile Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9474
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78485

<400>  9474
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaacauccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

aaugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cgaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacuauccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc auauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9475
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78485

<400>  9475
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caacauccuc      180

uuccagcugc agagcuccga cuuccacagc guguccaagc ugcgcgugcu cauccugugc      240

cacaaccgga uccagcagcu ggaccucaag acguucgagu ucaacaagga gcugcgcuac      300

cuggaccuca gcaacaaccg gcugaagucc gucaccuggu accugcucgc cgggcugcgc      360

uaccuggacc ucagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu ggggcucagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu gaacaccgug uuccucgggu uccggacgcu gccgcacuac      540

gaggagggca gccugcccau ccucaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu ggguccuccu gcgcgacggc aucaagacgu ccaagauccu ggagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu cagccuggag      720

aacgccaaga ccuccgugcu gcuccugaac aaggucgacc ugcucuggga cgaccuguuc      780

cugauccucc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc uggagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccugcuga ccaagaugga caucgagaac cugacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccug     1080

accgacgagc uguucaagcg gaccauccag cucccccacc ugaagacgcu cauccugaac     1140

ggcaacaagc uggagacccu cucccuggug agcugcuucg ccaacaacac gccccuggag     1200

caccucgacc ugucccagaa ccugcuccag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccuguccuac aacaagcuga gcgacuccgu guuccgcugc     1320

cuccccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accucauggc ccugcgggag cugaacaucg ccuucaacuu ccucaccgac     1440

cugcccgggu gcucccacuu cagccgccug uccguccuca acaucgagau gaacuucauc     1500

cugagcccgu cccuggacuu cgugcagagc ugccaggagg ugaagacccu caacgccggc     1560

cggaaccccu uccgcugcac gugcgagcug aagaacuuca uccagcugga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu caaccugcgg     1680

gggacccgcc ugaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcucauc     1740

gugaccaucg uggucaucau gcuggugcug ggccucgccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu ccgcaugcug gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcugaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccucug ggugaagaac gagcugaucc cgaaccugga gaaggaggac     1980

ggcuccaucc ucaucugccu guacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu gauccugcuc gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcugaaggc gcugcucgag aagaaggccu accuggagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cuccgcgccg ccaucaacgu caacgugcug     2340

gcgacccggg agauguacga gcugcagacc uucacggagc ucaacgagga gagccgcggc     2400

uccaccauca gccugaugcg gaccgacugc cuguga                               2436


<210>  9476
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78485

<400>  9476
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caacauccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

aacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg caccauccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9477
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78485

<400>  9477
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaauauucua      180

uuucagcucc aaaguagcga uuuccacucc guuucuaaac ugcgagugcu uauccugugc      240

cauaaccgua uucagcaguu ggaccucaag acuuuugagu ucaauaaaga acugagauac      300

cuggaucucu cgaacaauag guuaaaguca guaaccuggu aucugcuugc gggguugcgg      360

uaccuggacc ucagcuuuaa cgauuucgac acaaugccca ucugugagga agcuggaaau      420

augagucacc ucgagauacu gggucuuucc ggcgccaaaa uccagaaguc ugauuuucaa      480

aagauugcac aucugcacuu gaacaccgug uuccucgggu uucgcacucu gccucauuau      540

gaagagggaa gccuuccaau ccugaauaca accaaacucc acauuguccu ucccauggac      600

acgaacuucu gggugcuguu gagagauggc aucaagacuu ccaaaauacu agagaugacc      660

aauauugacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu gagccucgag      720

aaugccaaaa caucugugcu gcuucugaac aaggucgauu ugcucuggga cgaccuguuc      780

uuaauccugc aguuugugug gcacacuucc guagaacauu uccaaauucg gaacguuacc      840

uucgggggaa aggcuuaucu agaucacaau ucauuugacu acagcaacac agugaugcgc      900

accaucaaac ucgagcaugu ccacuuccga guguuuuaca uccagcagga uaagauuuau      960

cugcuuuuga cgaaaaugga cauagaaaau cugacuauca guaacgcaca gaugccucac     1020

augcuauucc caaauuaccc cacaaaguuu caauaucuga acuucgccaa uaacauucuu     1080

accgaugagc uguuuaaaag aacuauccag uugccucauc ucaagacacu gauauuaaau     1140

ggcaacaaac uggagacccu aucucucgug uccugcuucg cuaauaacac gccacuggaa     1200

caccuugacu ugagccagaa ucugcuccaa cauaagaacg augagaauug uucguggccg     1260

gaaaccgucg uuaacaugaa ccugucuuac aauaaguuau ccgacucagu guuuaggugc     1320

cugcccaaaa guauucagau ccuugauuug aacaauaacc agauccagac aguaccuaag     1380

gagacuauuc accucauggc ccugcgggaa cuaaauaucg cguucaacuu ucugaccgac     1440

cucccaggcu guagccauuu cucccgucug ucugugcuua auauugagau gaacuuuaua     1500

uugagccccu cacuggauuu cguccaaagu ugccaggagg ugaaaacauu aaaugcaggg     1560

cgcaacccuu ucagauguac uugcgaacuc aagaauuuua uccagcugga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccacu uaaccugagg     1680

gguacccggu ugaaagacgu ccaccuccac gaacugucau gcaauacugc ccuacugauu     1740

gugacgaucg uaguuaucau gcucgugcug ggccuugcug ucgccuucug cuguuugcau     1800

uuugaucugc ccugguacuu acgaaugcuc gggcagugca cacaaaccug gcaccgcgug     1860

agaaagacua cccaggagca gcugaagagg aacguccggu uccaugcauu uauuaguuac     1920

agcgagcacg acucccuuug ggugaaaaau gaacugauac cgaaccuaga gaaggaagau     1980

ggaucuaucc ucauuugucu guaugagucg uacuucgacc cuggcaaaag caucuccgag     2040

aacauuguuu cauuuaucga aaagaguuau aaaucuauau ucguguugag ccccaauuuu     2100

guacagaacg aguggugcca cuacgaguuc uauuuugcuc aucacaaucu guuccaugaa     2160

aacuccgauc acaucauuuu aauccuccug gaaccaauuc cuuuuuacug uauccccaca     2220

cgcuaucaua aguuaaaggc ccuguuggag aaaaaggcgu accucgagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggccaau cuacgugcag cuauaaacgu caaugugcug     2340

gccacccggg aaauguacga gcuucaaacu uucacagaac ucaacgagga aucacgaggg     2400

agcacgauuu cucugaugag aaccgauugu uuguga                               2436


<210>  9478
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78485

<400>  9478
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caacauccug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

aacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aaccauccag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9479
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78485

<400>  9479
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaauauccuu      180

uuucagcugc aauccucuga uuuccacagc guuuccaaac uccgggugcu gauucugugc      240

cauaaccgca uccagcagcu cgaccugaag acauuugagu ucaauaaaga acuuagauac      300

cuggaucucu cuaacaaucg gcucaagagc gugaccuggu aucuucuggc ugggcuccgc      360

uaccuggacc uguccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc ucgagauucu gggccuuucu ggggccaaaa uccagaaguc cgauuuucaa      480

aagauugcuc aucugcaccu caacaccguc uuccugggau uuagaacgcu uccccauuau      540

gaagagggca gccugccuau ccucaauacc acaaaacugc acauugugcu gcccauggac      600

accaacuucu ggguucuccu gcgggauggg aucaagacau cuaaaauucu ugagaugacc      660

aauaucgacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu gucucucgag      720

aaugccaaaa cguccguccu gcuucugaac aagguggauc uccuguggga cgaccuguuc      780

cucauccugc aguuuguuug gcacacaagc guggaacauu uccaaauuag aaacgucacc      840

uucggcggca aggcuuaucu ugaucacaau uccuuugacu acucuaacac agugaugcgg      900

accaucaaac uggagcaugu gcacuuccgc gucuuuuaca uucagcagga uaagaucuau      960

cuccugcuga ccaaaaugga cauugaaaau cuuacaauca gcaacgccca gaugccucac     1020

augcuguucc cgaauuaccc cacgaaguuu caauaucuga acuucgcgaa uaacauccug     1080

accgaugagc ucuuuaaaag aacaauucag cugccucauc uuaagacccu gauccucaau     1140

gggaacaaac uggagacacu gucccuuguu agcugcuucg ccaauaacac gccccucgaa     1200

caccuggacc ugucucagaa ucuccugcaa cauaagaacg augagaauug uuccuggccu     1260

gaaaccgugg ugaacaugaa ccuuagcuac aauaagcugu cugacagcgu cuuucggugc     1320

cuccccaaau ccauucagau ccuggaucug aacaauaacc agauucagac agugccgaag     1380

gagaccaucc accuuauggc ucuccgcgaa cugaauaucg ccuucaacuu ucugaccgac     1440

cucccuggau guucucauuu cagcagacug uccguucuua auauugagau gaacuuuauc     1500

cugagccccu cucucgauuu cgugcaaucc ugccaggagg ucaaaacacu gaaugcuggc     1560

cggaacccuu ucagauguac cugcgaacug aagaauuuua uucagcuuga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu caaccugcgc     1680

ggaacccggc ugaaagacgu gcaccuccac gaacugagcu gcaauacagc ccuucugauc     1740

gucaccauug uggucaucau gcucgugcug ggccuggcgg uugccuucug cugucuucau     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cacaaaccug gcaccgcgug     1860

cggaagacga cccaggagca gcucaagaga aacguccgcu uccaugcuuu uauuuccuac     1920

ucugagcacg acagccugug ggugaaaaau gaacuuaucc cuaaccugga gaaggaagau     1980

ggauccaucc ucauuugucu guaugagucu uacuucgacc cgggcaaaag caucuccgag     2040

aacauuguua gcuuuaucga aaagucuuau aaauccauuu ucgugcugag ccccaauuuu     2100

guccagaacg aguggugcca cuacgaguuc uauuuugccc aucacaaucu uuuccaugaa     2160

aacucugauc acaucauccu gauucuccug gaaccuaucc ccuuuuacug uauuccuaca     2220

cgguaucaua agcucaaggc ucugcuugag aaaaaggccu accuggagug gcccaaagac     2280

agacgcaagu gcggccucuu cugggccaau cugcgggcug cgaucaacgu gaaugugcug     2340

gccaccagag aaauguacga gcuucaaaca uucaccgaac ugaacgagga aucccgcggg     2400

agcacgauuu cucucaugcg gacagauugu cuguga                               2436


<210>  9480
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS28

<400>  9480

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Gln Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9481
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78486

<400>  9481
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

aaugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cgaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacuauccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc auauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucaaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9482
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78486

<400>  9482
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu caacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

aacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gaccauccag cugccccacc ucaagacgcu gauccugaac     1140

ggcaacaagc ucgagacccu gucccuggug agcugcuucg ccaacaacac gccccucgag     1200

caccuggacc ugucccagaa ccuccugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccuguccuac aacaagcuca gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccuggaccuc aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugcgggag cucaacaucg ccuucaacuu ccugaccgac     1440

cugcccgggu gcucccacuu cagccgccuc uccguccuga acaucgagau gaacuucauc     1500

cugagcccgu cccucgacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcug aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccugcgg     1680

gggacccgcc ucaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcuggugcuc ggccuggccg uggccuucug cugccugcac     1800

uucgaccucc ccugguaccu gcgcaugcug gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcucaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcugaucc cgaaccucga gaaggaggac     1980

ggcuccaucc ugaucugccu guacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcucag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu gauccuccug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcugaaggc gcuccuggag aagaaggccu accuggagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu caacgugcug     2340

gcgacccggg agauguacga gcuccagacc uucacggagc ugaacgagga gagccagggc     2400

uccaccauca gccugaugcg caccgacugc cucuga                               2436


<210>  9483
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78486

<400>  9483
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

aacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg caccauccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccagggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9484
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78486

<400>  9484
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugagu ucaauaaaga acugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuuuaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

aaugccaaaa caucugugcu ucuguugaac aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcacacuucc guagaacauu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucacaau ucauuugacu acagcaacac agugaugcgc      900

accauuaaac uggagcaugu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaau cucacuauaa guaacgcaca gaugccucac     1020

augcuguucc caaauuaccc cacaaaguuu caauaucuua acuucgccaa uaacauccug     1080

accgaugagu uguuuaaaag aacuauucag cucccucauc ugaagacauu aauccugaau     1140

ggcaacaaac uagagacccu cucucuggug uccugcuucg cuaauaacac gccacuugaa     1200

cacuuggacc ugagccagaa ucuccugcaa cauaagaacg augagaauug uucguggccg     1260

gaaaccgucg uuaacaugaa cuuaucuuac aauaagcugu ccgacucagu guuuaggugc     1320

cuucccaaaa guauacagau uuuggaucuc aacaauaacc agauccagac aguaccuaag     1380

gagacuaucc accugauggc ccuacgggaa cugaauauug cguucaacuu ucucaccgac     1440

cugccaggcu guagccauuu cucccgucuu ucuguguuga auaucgagau gaacuuuauu     1500

cugagccccu cauuagauuu cguccaaagu ugccaggagg ugaaaacacu caaugcaggg     1560

cgcaacccuu ucagauguac uugcgaacug aagaauuuua uacagcuuga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccacu gaacuugagg     1680

gguacccggc ucaaagacgu ccaucugcac gaacuaucau gcaauacugc ccugcucauc     1740

gugacgauug uaguuaucau gcuggugcuu ggcuuggcug ucgccuucug cugucugcac     1800

uuugauuuac ccugguaccu ccgaaugcug gggcagugca cacaaaccug gcaccgcgug     1860

agaaagacua cccaggagca gcuuaagagg aacguccggu uccaugcauu uaucaguuac     1920

agcgagcacg acucccugug ggugaaaaau gaacuaauuc cgaaccucga gaaggaagau     1980

ggaucuauac ugaucuguuu guaugagucg uacuucgacc cuggcaaaag cauuuccgag     2040

aacaucguuu cauuuauuga aaagaguuau aaaucuaucu ucgugcugag ccccaauuuu     2100

guacagaacg aguggugcca cuacgaguuc uauuuugcuc aucacaauuu auuccaugaa     2160

aacuccgauc acauaauccu cauucugcuu gaaccaaucc cuuuuuacug uauucccaca     2220

cgcuaucaua agcugaaggc cuugcucgag aaaaaggcgu accuggagug gccaaaagac     2280

agaaggaagu gcggucuauu cugggccaau cugcgugcag cuaucaacgu caaugugcuu     2340

gccacccggg aaauguacga gcuccaaacu uucacagaac ugaacgagga aucacagggg     2400

agcacgauau cuuugaugcg aaccgauugu cuguga                               2436


<210>  9485
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78486

<400>  9485
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

aacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aaccauccag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagccagggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9486
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78486

<400>  9486
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga acugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

aaugccaaaa cguccguccu ucugcucaac aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcacacaagc guggaacauu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucacaau uccuuugacu acucuaacac agugaugcgg      900

accauuaaac ucgagcaugu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaau cucacaauua gcaacgccca gaugccucac     1020

augcuguucc cgaauuaccc cacgaaguuu caauaucuga acuucgcgaa uaacauccuc     1080

accgaugagc uguuuaaaag aacaauccag cuuccucauc ugaagacccu cauucugaau     1140

gggaacaaac uggagacacu uucccucguu agcugcuucg ccaauaacac gccccuggaa     1200

caccuggacc ucucucagaa ucugcuucaa cauaagaacg augagaauug uuccuggccu     1260

gaaaccgugg ugaacaugaa ccugagcuac aauaagcucu cugacagcgu cuuucggugc     1320

cugcccaaau ccauccagau ucuggaucuu aacaauaacc agauccagac agugccgaag     1380

gagaccauuc accucauggc ucugcgcgaa cugaauaucg ccuucaacuu ucucaccgac     1440

cugccuggau guucucauuu cagcagacuu uccguucuga auaucgagau gaacuuuauu     1500

cucagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacacu gaaugcuggc     1560

cggaacccuu ucagauguac cugcgaacuu aagaauuuua uccagcucga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu gaaccugcgc     1680

ggaacccggc ucaaagacgu gcaccuucac gaacuuagcu gcaauacagc ccugcucauu     1740

gucaccaucg uggucauuau gcuggugcug ggccuugcgg uugccuucug cugucugcau     1800

uuugaucucc ccugguaccu gagaaugcuc gggcagugca cacaaaccug gcaccgcgug     1860

cggaagacga cccaggagca gcugaagaga aacguccgcu uccaugcuuu uaucuccuac     1920

ucugagcacg acagccuuug ggugaaaaau gaacugauuc cuaaccucga gaaggaagau     1980

ggauccaucc ugaucugucu guaugagucu uacuucgacc cgggcaaaag cauuuccgag     2040

aacaucguua gcuuuauuga aaagucuuau aaauccaucu ucgugcuuag ccccaauuuu     2100

guccagaacg aguggugcca cuacgaguuc uauuuugccc aucacaaucu guuccaugaa     2160

aacucugauc acauuauccu cauccugcuc gaaccuauuc ccuuuuacug uaucccuaca     2220

cgguaucaua agcugaaggc ucugcuggag aaaaaggccu accucgagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaau cugcgggcug cgauuaacgu gaaugugcuu     2340

gccaccagag aaauguacga gcugcaaaca uucaccgaac ucaacgagga aucccagggg     2400

agcacgaucu cucugaugcg cacagauugu cucuga                               2436


<210>  9487
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS29

<400>  9487

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ser His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Ile Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9488
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78487

<400>  9488
augagacuca ucagaaacau uuacauauuu uguaguauag uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acaacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauuucuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

caugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uauaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cuaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc acauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagacugu cuauaa                               2436


<210>  9489
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78487

<400>  9489
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucagcc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggcu cccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacga gcaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gucccuggag      720

cacgcgaaga ccagcgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac uccuucgacu acagcaacac caucaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgaucu ccaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccuc     1080

accgacgagc uguucaagcg gacccugcag cucccccacc ugaagacgcu gauccucaac     1140

ggcaacaagc uggagacccu gagccucguc uccugcuucg cgaacaacac gccccuggag     1200

caccuggacc ucagccagaa ccugcugcag cacaagaacg acgagaacug cuccuggccg     1260

gagaccgugg ugaacaugaa ccucagcuac aacaagcugu ccgacagcgu cuuccgcugc     1320

cugcccaagu ccauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaucg ccuucaacuu ccugaccgac     1440

cuccccgggu gcagccacuu cucccgccug agcgugcuga acaucgagau gaacuucauc     1500

cucuccccga gccuggacuu cguccagucc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggucggcug guccgacagc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu gcaccuccac gagcugagcu gcaacaccgc ccugcugauc     1740

gucaccaucg uggugaucau gcucguccug ggccuggcgg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccgggug     1860

cgcaagacca cgcaggagca gcugaagcgg aacguccgcu uccacgccuu caucuccuac     1920

agcgagcacg acucccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu cuacgagucc uacuucgacc ccggcaagag caucuccgag     2040

aacaucguga gcuucaucga gaaguccuac aagagcaucu ucguccuguc ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc ccugcuggag aagaaggcgu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu gaacguccuc     2340

gccacccggg agauguacga gcugcagacc uucacggagc ugaacgagga gucccgcggc     2400

agcaccaucu cccucaugcg gaccgacugc cuguga                               2436


<210>  9490
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78487

<400>  9490
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucuccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

cacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac caucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9491
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78487

<400>  9491
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugaau uuaauaaaga gcugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuucaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucagcc auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggau cccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu caaaaauccu ggagaugacc      660

aauauagacg guaagaguca guuuguuagc uacgaaaugc agaggaaccu cucucuggag      720

cacgcaaaaa cauccgugcu ucuguugaau aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcauacuuca guagaacacu uccaaauccg gaacguuacc      840

uucgggggaa aggccuaucu cgaucauaac agcuuugacu acaguaauac aauuaugcgc      900

accaucaaac uggagcacgu gcacuuccga gucuuuuaca uccagcagga uaagauuuau      960

cuuuugcuga cgaaaaugga cauagaaaac cucacuaucu cuaaugcuca gaugccucau     1020

augcuguucc caaacuaccc cacaaaguuu caauaucuua auuucgcaaa caauauucug     1080

accgaugagu uguuuaaaag aacucuccag cugccucacu uaaagacacu gauccuaaac     1140

ggcaauaaac ucgagacccu gucccuugug agcugcuucg ccaacaauac gccauuggaa     1200

caucuggacc ucucgcagaa ccuguuacaa cacaagaaug augagaacug uucuuggccg     1260

gaaaccgugg ucaauaugaa ccuguccuac aacaaacuuu cagacagugu uuuuaggugc     1320

uugcccaaga gcauacagau ucucgaucug aauaacaauc agauccagac agugccuaag     1380

gagacuaucc aucuaauggc ucugcgggaa cucaacauug ccuucaauuu ucugaccgac     1440

cuuccaggcu guucccacuu cucucguuug agcguacuga acaucgagau gaauuuuauu     1500

uuaucaccca gucucgauuu cgugcaaucc ugccaggagg ucaaaacacu gaacgcgggg     1560

cgcaauccuu ucagauguac uugcgaacuu aagaacuuua uacagcugga gaccuauagc     1620

gaagugauga ugguuggaug gucugacuca uacacaugug aguauccauu gaaucucagg     1680

gguacccggc ugaaagacgu gcaccuacau gaacugaguu gcaacacugc acuccugauc     1740

gucacgauug ugguaaucau gcuuguuuug ggccuggccg uggcuuucug cuguuuacac     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cacaaaccug gcaucgcguc     1860

agaaagacua cccaggagca gcugaagagg aaugugcggu uccacgccuu uaucagcuac     1920

uccgagcacg acucucuaug ggucaaaaac gaacucauuc cgaaucugga gaaggaagau     1980

ggaucgauau ugaucugucu guaugagagc uacuucgacc cuggcaaauc cauuucagag     2040

aacaucguga guuuuauuga aaagucuuau aaaagcaucu ucguuuuauc ccccaacuuu     2100

gugcagaaug aguggugcca uuacgaguuc uauuuugcac accauaaccu cuuccacgaa     2160

aauucagauc auauaauccu gauucuucug gaaccaaucc cuuuuuacug uauucccaca     2220

cgcuaucaca aguugaaggc ucuccuggag aaaaaggccu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggcgaac cuucgugccg caaucaaugu aaacguccuc     2340

gcuacccggg aaauguacga gcugcaaacu uucacagaau ugaaugagga aagccgaggg     2400

ucuacgauau cccugaugag aaccgauugu uuauga                               2436


<210>  9492
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78487

<400>  9492
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucagcc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

cacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac caucaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9493
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78487

<400>  9493
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga gcugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucagcc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggcu cucucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau ccaaaauccu ggagaugacc      660

aauauugacg gaaagagcca guuugugucu uacgaaaugc agcgcaaccu cucccuggag      720

cacgcuaaaa cgagcguccu ucugcucaau aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcauacaucc guggaacacu uccaaaucag aaacgucacc      840

uucggcggca aggccuaucu ggaucauaac ucuuuugacu acagcaauac aauuaugcgg      900

accaucaaac ucgagcacgu gcacuuccgc guguuuuaca uucagcagga uaagaucuau      960

cugcugcuua ccaaaaugga cauugaaaac cucacaaucu ccaaugcuca gaugccucau     1020

augcuguucc cgaacuaccc cacgaaguuu caauaucuga auuucgccaa caauauccuc     1080

accgaugagc uguuuaaaag aacacuucag cugccucacc ucaagacccu gauucugaac     1140

gggaauaaac uugagacacu cagccugguc ucuugcuucg cgaacaauac gccccuggaa     1200

caucucgacc ugucccagaa ccuucugcaa cacaagaaug augagaacug uagcuggccu     1260

gaaaccguug ugaauaugaa ccucucuuac aacaagcuga gcgacuccgu guuucggugc     1320

cugcccaaau cuauccagau ucuugaucuc aauaacaauc agauccagac agucccgaag     1380

gagaccauuc aucugauggc ccugcgcgaa cucaacaucg cuuucaauuu ucugaccgac     1440

cuuccuggau guagccacuu cuccagacug agcgugcuca acaucgagau gaauuuuauu     1500

cugucucccu cccuggauuu cguucaaagc ugccaggagg ugaaaacacu uaacgccggc     1560

cggaauccuu ucagauguac cugcgaacuc aagaacuuua uccagcugga gacauauucu     1620

gaagucauga ugguggggug guccgacagc uacacgugug aguauccccu gaaucuccgc     1680

ggaacccggc ugaaagacgu ucaccuucau gaacuguccu gcaacacagc ucuccugauu     1740

gugaccaucg ucgugauuau gcugguccuu ggccuggccg uggcguucug cugucuccac     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cacaaaccug gcaucgcguu     1860

cggaagacga cccaggagca gcuuaagaga aaugugcgcu uccacgccuu uaucucuuac     1920

agcgagcacg acucccugug ggucaaaaac gaacucauuc cuaaucugga gaaggaagau     1980

ggaucuaucc ugaucugucu uuaugagagc uacuucgacc cgggcaaauc cauuagcgag     2040

aacaucgugu cuuuuauuga aaaguccuau aaaagcaucu ucguucuguc ucccaacuuu     2100

gugcagaaug aguggugcca uuacgaguuc uauuuugcuc accauaaccu cuuccacgaa     2160

aauuccgauc auauuauccu gauccuccug gaaccuauuc ccuuuuacug uaucccuaca     2220

cgguaucaca aacuuaaggc ccugcucgaa aagaaggcuu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaac cuucgggccg cuauuaaugu caacgugcug     2340

gcgaccagag aaauguacga gcuccaaaca uucaccgaac ugaaugagga aagccgcggg     2400

ucuacgauca gccucaugcg gacagauugu cuguga                               2436


<210>  9494
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__D1CS30

<400>  9494

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ser His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Ile Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Thr Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Leu Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9495
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAY78488

<400>  9495
augagacuca ucagaaacau uuacauauuu uguaguauag uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acaacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauuucuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

caugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uauaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaacgga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cuaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacucuccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc acauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagacugu cuauaa                               2436


<210>  9496
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAY78488

<400>  9496
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucagcc accuccaccu gaacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggcu cccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacga gcaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gucccuggag      720

cacgcgaaga ccagcgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac uccuucgacu acagcaacac caucaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagacgga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccuc     1080

accgacgagc uguucaagcg gacgcugcag cucccccacc ugaagacccu gauccucaac     1140

ggcaacaagc uggagacccu gagccucguc uccugcuucg cgaacaacac gccccuggag     1200

caccuggacc ucagccagaa ccugcugcag cacaagaacg acgagaacug cuccuggccg     1260

gagaccgugg ugaacaugaa ccucagcuac aacaagcugu ccgacagcgu cuuccgcugc     1320

cugcccaagu ccauccagau ccucgaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccuccgggag cugaacaucg ccuucaacuu ccugaccgac     1440

cuccccgggu gcagccacuu cucccgccug agcgugcuga acaucgagau gaacuucauc     1500

cucuccccga gccuggacuu cguccagucc ugccaggagg ugaagacgcu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcuc aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggucggcug guccgacagc uacacgugcg aguacccccu gaaccuccgg     1680

gggacccgcc ugaaggacgu gcaccuccac gagcugagcu gcaacaccgc ccugcugauc     1740

gucaccaucg uggugaucau gcucguccug ggccuggcgg uggccuucug cugccuccac     1800

uucgaccugc ccugguaccu gcgcaugcuc gggcagugca cccagaccug gcaccgggug     1860

cgcaagacca cccaggagca gcugaagcgg aacguccgcu uccacgccuu caucuccuac     1920

agcgagcacg acucccugug ggugaagaac gagcucaucc cgaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu cuacgagucc uacuucgacc ccggcaagag caucuccgag     2040

aacaucguga gcuucaucga gaaguccuac aagagcaucu ucguccuguc ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu cauccugcug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcucaaggc ccugcuggag aagaaggcgu accucgagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu gaacguccuc     2340

gccacccggg agauguacga gcugcagacg uucaccgagc ugaacgagga gucccgcggc     2400

agcaccaucu cccucaugcg gaccgacugc cuguga                               2436


<210>  9497
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAY78488

<400>  9497
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucuccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

cacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac caucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaccga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg cacccuccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9498
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAY78488

<400>  9498
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugaau uuaauaaaga gcugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuucaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucagcc auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggau cccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu caaaaauccu ggagaugacc      660

aauauagacg guaagaguca guuuguuagc uacgaaaugc agaggaaccu cucucuggag      720

cacgcaaaaa cauccgugcu ucuguugaau aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcauacuuca guagaacacu uccaaauccg gaacguuacc      840

uucgggggaa aggccuaucu cgaucauaac agcuuugacu acaguaauac aauuaugcgc      900

accaucaaac uggagcacgu gcacuuccga gucuuuuaca uccagcagga uaagauuuau      960

cuuuugcuga cgaaaacuga cauagaaaac cucacaaucu cuaaugcuca gaugccucau     1020

augcuguucc caaacuaccc caccaaguuu caauaucuua auuucgcaaa caauauucug     1080

acugaugagu uguuuaaaag aacacuccag cugccucacu uaaagacccu gauccuaaac     1140

ggcaauaaac ucgagacgcu gucccuugug agcugcuucg ccaacaauac cccauuggaa     1200

caucuggacc ucucgcagaa ccuguuacaa cacaagaaug augagaacug uucuuggccg     1260

gaaacagugg ucaauaugaa ccuguccuac aacaaacuuu cagacagugu uuuuaggugc     1320

uugcccaaga gcauacagau ucucgaucug aauaacaauc agauccagac ugugccuaag     1380

gagaccaucc aucuaauggc ucugcgggaa cucaacauug ccuucaauuu ucugacagac     1440

cuuccaggcu guucccacuu cucucguuug agcguacuga acaucgagau gaauuuuauu     1500

uuaucaccca gucucgauuu cgugcaaucc ugccaggagg ucaaaacucu gaacgcgggg     1560

cgcaauccuu ucagauguac cugcgaacuu aagaacuuua uacagcugga gacauauagc     1620

gaagugauga ugguuggaug gucugacuca uacaccugug aguauccauu gaaucucagg     1680

gguacucggc ugaaagacgu gcaccuacau gaacugaguu gcaacacggc acuccugauc     1740

gucacaauug ugguaaucau gcuuguuuug ggccuggccg uggcuuucug cuguuuacac     1800

uuugaucucc ccugguaccu gcgaaugcuu gggcagugca cccaaacuug gcaucgcguc     1860

agaaagacca cacaggagca gcugaagagg aaugugcggu uccacgccuu uaucagcuac     1920

uccgagcacg acucucuaug ggucaaaaac gaacucauuc cgaaucugga gaaggaagau     1980

ggaucgauau ugaucugucu guaugagagc uacuucgacc cuggcaaauc cauuucagag     2040

aacaucguga guuuuauuga aaagucuuau aaaagcaucu ucguuuuauc ccccaacuuu     2100

gugcagaaug aguggugcca uuacgaguuc uauuuugcac accauaaccu cuuccacgaa     2160

aauucagauc auauaauccu gauucuucug gaaccaaucc cuuuuuacug uauucccacc     2220

cgcuaucaca aguugaaggc ucuccuggag aaaaaggccu accuagagug gccaaaagac     2280

agaaggaagu gcggucuguu cugggcgaac cuucgugccg caaucaaugu aaacguccuc     2340

gcuacucggg aaauguacga gcugcaaaca uucacggaau ugaaugagga aagccgaggg     2400

ucuaccauau cccugaugag aacugauugu uuauga                               2436


<210>  9499
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAY78488

<400>  9499
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucagcc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

cacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac caucaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaccga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aacccugcag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9500
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAY78488

<400>  9500
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga gcugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucagcc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggcu cucucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau ccaaaauccu ggagaugacc      660

aauauugacg gaaagagcca guuugugucu uacgaaaugc agcgcaaccu cucccuggag      720

cacgcuaaaa cgagcguccu ucugcucaau aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcauacaucc guggaacacu uccaaaucag aaacgucacc      840

uucggcggca aggccuaucu ggaucauaac ucuuuugacu acagcaauac aauuaugcgg      900

accaucaaac ucgagcacgu gcacuuccgc guguuuuaca uucagcagga uaagaucuau      960

cugcugcuua ccaaaacaga cauugaaaac cucacgaucu ccaaugcuca gaugccucau     1020

augcuguucc cgaacuaccc caccaaguuu caauaucuga auuucgccaa caauauccuc     1080

acagaugagc uguuuaaaag aacccuucag cugccucacc ucaagacacu gauucugaac     1140

gggaauaaac uugagacccu cagccugguc ucuugcuucg cgaacaauac gccccuggaa     1200

caucucgacc ugucccagaa ccuucugcaa cacaagaaug augagaacug uagcuggccu     1260

gaaacaguug ugaauaugaa ccucucuuac aacaagcuga gcgacuccgu guuucggugc     1320

cugcccaaau cuauccagau ucuugaucuc aauaacaauc agauccagac cgucccgaag     1380

gagaccauuc aucugauggc ccugcgcgaa cucaacaucg cuuucaauuu ucugacagac     1440

cuuccuggau guagccacuu cuccagacug agcgugcuca acaucgagau gaauuuuauu     1500

cugucucccu cccuggauuu cguucaaagc ugccaggagg ugaaaacccu uaacgccggc     1560

cggaauccuu ucagauguac augcgaacuc aagaacuuua uccagcugga gacguauucu     1620

gaagucauga ugguggggug guccgacagc uacaccugug aguauccccu gaaucuccgc     1680

ggaacacggc ugaaagacgu ucaccuucau gaacuguccu gcaacaccgc ucuccugauu     1740

gugacaaucg ucgugauuau gcugguccuu ggccuggccg uggcguucug cugucuccac     1800

uuugaucugc ccugguaccu cagaaugcug gggcagugca cccaaacgug gcaucgcguu     1860

cggaagacca cacaggagca gcuuaagaga aaugugcgcu uccacgccuu uaucucuuac     1920

agcgagcacg acucccugug ggucaaaaac gaacucauuc cuaaucugga gaaggaagau     1980

ggaucuaucc ugaucugucu uuaugagagc uacuucgacc cgggcaaauc cauuagcgag     2040

aacaucgugu cuuuuauuga aaaguccuau aaaagcaucu ucguucuguc ucccaacuuu     2100

gugcagaaug aguggugcca uuacgaguuc uauuuugcuc accauaaccu cuuccacgaa     2160

aauuccgauc auauuauccu gauccuccug gaaccuauuc ccuuuuacug uaucccuacc     2220

cgguaucaca aacuuaaggc ccugcucgaa aagaaggcuu accuggagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaac cuucgggccg cuauuaaugu caacgugcug     2340

gcgacaagag aaauguacga gcuccaaacc uucacggaac ugaaugagga aagccgcggg     2400

ucuacaauca gccucaugcg gaccgauugu cuguga                               2436


<210>  9501
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__Q9BXR5

<400>  9501

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  9502
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR10__Homo_sapiens__AAH89406

<400>  9502
augagacuca ucagaaacau uuacauauuu uguaguauug uuaugacagc agagggugau       60

gcuccagagc ugccagaaga aagggaacug augaccaacu gcuccaacau gucucuaaga      120

aagguucccg cagacuugac cccagccaca acgacacugg auuuauccua uaaccuccuu      180

uuucaacucc agaguucaga uuuucauucu gucuccaaac ugagaguuuu gauucuaugc      240

cauaacagaa uucaacagcu ggaucucaaa accuuugaau ucaacaagga guuaagauau      300

uuagauuugu cuaauaacag acugaagagu guaacuuggu auuuacuggc aggucucagg      360

uauuuagauc uuucuuuuaa ugacuuugac accaugccua ucugugagga agcuggcaac      420

augucacacc uggaaauccu agguuugagu ggggcaaaaa uacaaaaauc agauuuccag      480

aaaauugcuc aucugcaucu aaauacuguc uucuuaggau ucagaacucu uccucauuau      540

gaagaaggua gccugcccau cuuaaacaca acaaaacugc acauuguuuu accaauggac      600

acaaauuucu ggguucuuuu gcgugaugga aucaagacuu caaaaauauu agaaaugaca      660

aauauagaug gcaaaagcca auuuguaagu uaugaaaugc aacgaaaucu uaguuuagaa      720

aaugcuaaga caucgguucu auugcuuaau aaaguugauu uacucuggga cgaccuuuuc      780

cuuaucuuac aauuuguuug gcauacauca guggaacacu uucagauccg aaaugugacu      840

uuugguggua aggcuuaucu ugaccacaau ucauuugacu acucaaauac uguaaugaga      900

acuauaaaau uggagcaugu acauuucaga guguuuuaca uucaacagga uaaaaucuau      960

uugcuuuuga ccaaaaugga cauagaaaac cugacaauau caaaugcaca aaugccacac     1020

augcuuuucc cgaauuaucc uacgaaauuc caauauuuaa auuuugccaa uaauaucuua     1080

acagacgagu uguuuaaaag aacuauccaa cugccucacu ugaaaacucu cauuuugaau     1140

ggcaauaaac uggagacacu uucuuuagua aguugcuuug cuaacaacac acccuuggaa     1200

cacuuggauc ugagucaaaa ucuauuacaa cauaaaaaug augaaaauug cucauggcca     1260

gaaacugugg ucaauaugaa ucugucauac aauaaauugu cugauucugu cuucaggugc     1320

uugcccaaaa guauucaaau acuugaccua aauaauaacc aaauccaaac uguaccuaaa     1380

gagacuauuc aucugauggc cuuacgagaa cuaaauauug cauuuaauuu ucuaacugau     1440

cucccuggau gcagucauuu caguagacuu ucaguucuga acauugaaau gaacuucauu     1500

cucagcccau cucuggauuu uguucagagc ugccaggaag uuaaaacucu aaaugcggga     1560

agaaauccau uccgguguac cugugaauua aaaaauuuca uucagcuuga aacauauuca     1620

gaggucauga ugguuggaug gucagauuca uacaccugug aauacccuuu aaaccuaagg     1680

ggaacuaggu uaaaagacgu ucaucuccac gaauuaucuu gcaacacagc ucuguugauu     1740

gucaccauug ugguuauuau gcuaguucug ggguuggcug uggccuucug cugucuccac     1800

uuugaucugc ccugguaucu caggaugcua ggucaaugca cacaaacaug gcacaggguu     1860

aggaaaacaa cccaagaaca acucaagaga aauguccgau uccacgcauu uauuucauac     1920

agugaacaug auucucugug ggugaagaau gaauugaucc ccaaucuaga gaaggaagau     1980

gguucuaucu ugauuugccu uuaugaaagc uacuuugacc cuggcaaaag cauuagugaa     2040

aauauuguaa gcuucauuga gaaaagcuau aaguccaucu uuguuuuguc ucccaacuuu     2100

guccagaaug aguggugcca uuaugaauuc uacuuugccc accacaaucu cuuccaugaa     2160

aauucugauc auauaauucu uaucuuacug gaacccauuc cauucuauug cauucccacc     2220

agguaucaua aacugaaagc ucuccuggaa aaaaaagcau acuuggaaug gcccaaggau     2280

aggcguaaau gugggcuuuu cugggcaaac cuucgagcug cuauuaaugu uaauguauua     2340

gccaccagag aaauguauga acugcagaca uucacagagu uaaaugaaga gucucgaggu     2400

ucuacaaucu cucugaugag aacagauugu cuauaa                               2436


<210>  9503
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR10__Homo_sapiens__AAH89406

<400>  9503
augcgccuga uccggaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ucccggagga gcgcgagcug augaccaacu gcuccaacau gagccugcgg      120

aagguccccg cggaccucac gcccgccacc accacccugg accuguccua caaccuccug      180

uuccagcugc agagcuccga cuuccacagc guguccaagc uccgcgugcu gauccugugc      240

cacaaccgga uccagcagcu cgaccugaag acguucgagu ucaacaagga gcugcgcuac      300

cucgaccuga gcaacaaccg gcugaagucc gucaccuggu accuccuggc cgggcugcgc      360

uaccucgacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc uggagauccu cgggcugagc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgcgc accuccaccu caacaccgug uuccuggggu uccggacgcu gccgcacuac      540

gaggagggca gccuccccau ccugaacacc accaagcugc acaucgugcu ccccauggac      600

accaacuucu ggguccugcu gcgcgacggc aucaagacgu ccaagauccu cgagaugacc      660

aacaucgacg ggaaguccca guucgugagc uacgagaugc agcggaaccu gagccuggag      720

aacgccaaga ccuccgugcu ccugcugaac aaggucgacc uccuguggga cgaccuguuc      780

cucauccugc aguucgugug gcacaccagc guggagcacu uccagauccg caacgucacg      840

uucggcggga aggccuaccu ggaccacaac agcuucgacu acuccaacac cgugaugcgg      900

accaucaagc ucgagcacgu gcacuuccgc gucuucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cucacgauca gcaacgccca gaugccccac     1020

augcuguucc cgaacuaccc caccaaguuc caguaccuga acuucgcgaa caacauccuc     1080

accgacgagc uguucaagcg gaccauccag cugccccacc ucaagacgcu gauccugaac     1140

ggcaacaagc ucgagacccu gucccuggug agcugcuucg ccaacaacac gccccucgag     1200

caccuggacc ugucccagaa ccuccugcag cacaagaacg acgagaacug cagcuggccg     1260

gagaccgugg ucaacaugaa ccuguccuac aacaagcuca gcgacuccgu guuccgcugc     1320

cugcccaaga gcauccagau ccuggaccuc aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugcgggag cucaacaucg ccuucaacuu ccugaccgac     1440

cugcccgggu gcucccacuu cagccgccuc uccguccuga acaucgagau gaacuucauc     1500

cugagcccgu cccucgacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

cggaaccccu uccgcugcac gugcgagcug aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggugggcug gagcgacucc uacacgugcg aguacccccu gaaccugcgg     1680

gggacccgcc ucaaggacgu ccaccuccac gagcugagcu gcaacaccgc gcugcugauc     1740

gugaccaucg uggucaucau gcuggugcuc ggccuggccg uggccuucug cugccugcac     1800

uucgaccucc ccugguaccu gcgcaugcug gggcagugca cccagaccug gcaccggguc     1860

cgcaagacca cgcaggagca gcucaagcgg aacgugcgcu uccacgccuu caucagcuac     1920

uccgagcacg acagccugug ggugaagaac gagcugaucc cgaaccucga gaaggaggac     1980

ggcuccaucc ugaucugccu guacgagagc uacuucgacc ccggcaaguc caucagcgag     2040

aacaucgucu ccuucaucga gaaguccuac aagagcaucu ucgugcucag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacuccgacc acaucauccu gauccuccug gagcccaucc cguucuacug cauccccacc     2220

cgguaccaca agcugaaggc gcuccuggag aagaaggccu accuggagug gcccaaggac     2280

cgccggaagu gcgggcuguu cugggccaac cugcgcgccg ccaucaacgu caacgugcug     2340

gcgacccggg agauguacga gcuccagacc uucacggagc ugaacgagga gagccgcggc     2400

uccaccauca gccugaugcg gaccgacugc cucuga                               2436


<210>  9504
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR10__Homo_sapiens__AAH89406

<400>  9504
augcgccuca uccgcaacau cuacaucuuc ugcuccaucg ucaugaccgc cgagggcgac       60

gcccccgagc uccccgagga gcgcgagcuc augaccaacu gcuccaacau gucccuccgc      120

aagguccccg ccgaccucac ccccgccacc accacccucg accucuccua caaccuccuc      180

uuccagcucc aguccuccga cuuccacucc gucuccaagc uccgcguccu cauccucugc      240

cacaaccgca uccagcagcu cgaccucaag accuucgagu ucaacaagga gcuccgcuac      300

cucgaccucu ccaacaaccg ccucaagucc gucaccuggu accuccucgc cggccuccgc      360

uaccucgacc ucuccuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augucccacc ucgagauccu cggccucucc ggcgccaaga uccagaaguc cgacuuccag      480

aagaucgccc accuccaccu caacaccguc uuccucggcu uccgcacccu cccccacuac      540

gaggagggcu cccuccccau ccucaacacc accaagcucc acaucguccu ccccauggac      600

accaacuucu ggguccuccu ccgcgacggc aucaagaccu ccaagauccu cgagaugacc      660

aacaucgacg gcaaguccca guucgucucc uacgagaugc agcgcaaccu cucccucgag      720

aacgccaaga ccuccguccu ccuccucaac aaggucgacc uccucuggga cgaccucuuc      780

cucauccucc aguucgucug gcacaccucc gucgagcacu uccagauccg caacgucacc      840

uucggcggca aggccuaccu cgaccacaac uccuucgacu acuccaacac cgucaugcgc      900

accaucaagc ucgagcacgu ccacuuccgc gucuucuaca uccagcagga caagaucuac      960

cuccuccuca ccaagaugga caucgagaac cucaccaucu ccaacgccca gaugccccac     1020

augcucuucc ccaacuaccc caccaaguuc caguaccuca acuucgccaa caacauccuc     1080

accgacgagc ucuucaagcg caccauccag cucccccacc ucaagacccu cauccucaac     1140

ggcaacaagc ucgagacccu cucccucguc uccugcuucg ccaacaacac cccccucgag     1200

caccucgacc ucucccagaa ccuccuccag cacaagaacg acgagaacug cuccuggccc     1260

gagaccgucg ucaacaugaa ccucuccuac aacaagcucu ccgacuccgu cuuccgcugc     1320

cuccccaagu ccauccagau ccucgaccuc aacaacaacc agauccagac cguccccaag     1380

gagaccaucc accucauggc ccuccgcgag cucaacaucg ccuucaacuu ccucaccgac     1440

cuccccggcu gcucccacuu cucccgccuc uccguccuca acaucgagau gaacuucauc     1500

cucucccccu cccucgacuu cguccagucc ugccaggagg ucaagacccu caacgccggc     1560

cgcaaccccu uccgcugcac cugcgagcuc aagaacuuca uccagcucga gaccuacucc     1620

gaggucauga uggucggcug guccgacucc uacaccugcg aguacccccu caaccuccgc     1680

ggcacccgcc ucaaggacgu ccaccuccac gagcucuccu gcaacaccgc ccuccucauc     1740

gucaccaucg ucgucaucau gcucguccuc ggccucgccg ucgccuucug cugccuccac     1800

uucgaccucc ccugguaccu ccgcaugcuc ggccagugca cccagaccug gcaccgcguc     1860

cgcaagacca cccaggagca gcucaagcgc aacguccgcu uccacgccuu caucuccuac     1920

uccgagcacg acucccucug ggucaagaac gagcucaucc ccaaccucga gaaggaggac     1980

ggcuccaucc ucaucugccu cuacgagucc uacuucgacc ccggcaaguc caucuccgag     2040

aacaucgucu ccuucaucga gaaguccuac aaguccaucu ucguccucuc ccccaacuuc     2100

guccagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu cuuccacgag     2160

aacuccgacc acaucauccu cauccuccuc gagcccaucc ccuucuacug cauccccacc     2220

cgcuaccaca agcucaaggc ccuccucgag aagaaggccu accucgagug gcccaaggac     2280

cgccgcaagu gcggccucuu cugggccaac cuccgcgccg ccaucaacgu caacguccuc     2340

gccacccgcg agauguacga gcuccagacc uucaccgagc ucaacgagga gucccgcggc     2400

uccaccaucu cccucaugcg caccgacugc cucuga                               2436


<210>  9505
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR10__Homo_sapiens__AAH89406

<400>  9505
augagacuga ucaggaacau uuacauauuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgggagcuu augacaaauu guuccaacau gucucugcgc      120

aaggucccag cagauuugac uccggccacg accacauuag accugucaua uaaucuacuc      180

uuucagcugc aaaguagcga uuuccacucc guuucuaaac uucgagugcu gauuuugugc      240

cauaaccgua uccagcagcu cgaccugaag acuuuugagu ucaauaaaga acugagauac      300

cucgauuuau cgaacaauag gcugaaguca guaaccuggu aucuuuuggc ggggcugcgg      360

uaccuagacc ucagcuuuaa cgauuucgac acaaugccca uuugugagga agcuggaaau      420

augagucacc uggagauccu uggucugucc ggcgccaaaa uacagaaguc ugauuuucaa      480

aagaucgcac auuugcaccu caacaccgug uuccuggggu uucgcacuuu accucauuau      540

gaagagggaa gccugccaau ucucaauaca accaaacuuc acaucguccu gcccauggac      600

acgaacuucu ggguguugcu aagagauggc auuaagacuu ccaaaauccu ggagaugacc      660

aauauagacg guaagucaca guuuguuagu uacgaaaugc agaggaaccu cagccuggag      720

aaugccaaaa caucugugcu ucuguugaac aaggucgauc uccuguggga cgacuuauuc      780

cugauucuac aguuugugug gcacacuucc guagaacauu uccaaauccg gaacguuacc      840

uucgggggaa aggcuuaucu cgaucacaau ucauuugacu acagcaacac agugaugcgc      900

accauuaaac uggagcaugu ccacuuccga guguuuuaca uccagcagga uaagaucuau      960

cuuuugcuga cgaaaaugga cauugaaaau cucacuauaa guaacgcaca gaugccucac     1020

augcuguucc caaauuaccc cacaaaguuu caauaucuua acuucgccaa uaacauccug     1080

accgaugagu uguuuaaaag aacuauucag cucccucauc ugaagacauu aauccugaau     1140

ggcaacaaac uagagacccu cucucuggug uccugcuucg cuaauaacac gccacuugaa     1200

cacuuggacc ugagccagaa ucuccugcaa cauaagaacg augagaauug uucguggccg     1260

gaaaccgucg uuaacaugaa cuuaucuuac aauaagcugu ccgacucagu guuuaggugc     1320

cuucccaaaa guauacagau uuuggaucuc aacaauaacc agauccagac aguaccuaag     1380

gagacuaucc accugauggc ccuacgggaa cugaauauug cguucaacuu ucucaccgac     1440

cugccaggcu guagccauuu cucccgucuu ucuguguuga auaucgagau gaacuuuauu     1500

cugagccccu cauuagauuu cguccaaagu ugccaggagg ugaaaacacu caaugcaggg     1560

cgcaacccuu ucagauguac uugcgaacug aagaauuuua uacagcuuga gaccuauucc     1620

gaaguuauga uggugggaug gagcgacucu uacacaugug aguauccacu gaacuugagg     1680

gguacccggc ucaaagacgu ccaucugcac gaacuaucau gcaauacugc ccugcucauc     1740

gugacgauug uaguuaucau gcuggugcuu ggcuuggcug ucgccuucug cugucugcac     1800

uuugauuuac ccugguaccu ccgaaugcug gggcagugca cacaaaccug gcaccgcgug     1860

agaaagacua cccaggagca gcuuaagagg aacguccggu uccaugcauu uaucaguuac     1920

agcgagcacg acucccugug ggugaaaaau gaacuaauuc cgaaccucga gaaggaagau     1980

ggaucuauac ugaucuguuu guaugagucg uacuucgacc cuggcaaaag cauuuccgag     2040

aacaucguuu cauuuauuga aaagaguuau aaaucuaucu ucgugcugag ccccaauuuu     2100

guacagaacg aguggugcca cuacgaguuc uauuuugcuc aucacaauuu auuccaugaa     2160

aacuccgauc acauaauccu cauucugcuu gaaccaaucc cuuuuuacug uauucccaca     2220

cgcuaucaua agcugaaggc cuugcucgag aaaaaggcgu accuggagug gccaaaagac     2280

agaaggaagu gcggucuauu cugggccaau cugcgugcag cuaucaacgu caaugugcuu     2340

gccacccggg aaauguacga gcuccaaacu uucacagaac ugaacgagga aucacgaggg     2400

agcacgauau cuuugaugag aaccgauugu cuguga                               2436


<210>  9506
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR10__Homo_sapiens__AAH89406

<400>  9506
augagacuga ucagaaacau cuacaucuuc ugcagcaucg ugaugaccgc cgagggcgac       60

gcccccgagc ugcccgagga gagagagcug augaccaacu gcagcaacau gagccugaga      120

aaggugcccg ccgaccugac ccccgccacc accacccugg accugagcua caaccugcug      180

uuccagcugc agagcagcga cuuccacagc gugagcaagc ugagagugcu gauccugugc      240

cacaacagaa uccagcagcu ggaccugaag accuucgagu ucaacaagga gcugagauac      300

cuggaccuga gcaacaacag acugaagagc gugaccuggu accugcuggc cggccugaga      360

uaccuggacc ugagcuucaa cgacuucgac accaugccca ucugcgagga ggccggcaac      420

augagccacc uggagauccu gggccugagc ggcgccaaga uccagaagag cgacuuccag      480

aagaucgccc accugcaccu gaacaccgug uuccugggcu ucagaacccu gccccacuac      540

gaggagggca gccugcccau ccugaacacc accaagcugc acaucgugcu gcccauggac      600

accaacuucu gggugcugcu gagagacggc aucaagacca gcaagauccu ggagaugacc      660

aacaucgacg gcaagagcca guucgugagc uacgagaugc agagaaaccu gagccuggag      720

aacgccaaga ccagcgugcu gcugcugaac aagguggacc ugcuguggga cgaccuguuc      780

cugauccugc aguucgugug gcacaccagc guggagcacu uccagaucag aaacgugacc      840

uucggcggca aggccuaccu ggaccacaac agcuucgacu acagcaacac cgugaugaga      900

accaucaagc uggagcacgu gcacuucaga guguucuaca uccagcagga caagaucuac      960

cugcugcuga ccaagaugga caucgagaac cugaccauca gcaacgccca gaugccccac     1020

augcuguucc ccaacuaccc caccaaguuc caguaccuga acuucgccaa caacauccug     1080

accgacgagc uguucaagag aaccauccag cugccccacc ugaagacccu gauccugaac     1140

ggcaacaagc uggagacccu gagccuggug agcugcuucg ccaacaacac cccccuggag     1200

caccuggacc ugagccagaa ccugcugcag cacaagaacg acgagaacug cagcuggccc     1260

gagaccgugg ugaacaugaa ccugagcuac aacaagcuga gcgacagcgu guucagaugc     1320

cugcccaaga gcauccagau ccuggaccug aacaacaacc agauccagac cgugcccaag     1380

gagaccaucc accugauggc ccugagagag cugaacaucg ccuucaacuu ccugaccgac     1440

cugcccggcu gcagccacuu cagcagacug agcgugcuga acaucgagau gaacuucauc     1500

cugagcccca gccuggacuu cgugcagagc ugccaggagg ugaagacccu gaacgccggc     1560

agaaaccccu ucagaugcac cugcgagcug aagaacuuca uccagcugga gaccuacagc     1620

gaggugauga uggugggcug gagcgacagc uacaccugcg aguacccccu gaaccugaga     1680

ggcaccagac ugaaggacgu gcaccugcac gagcugagcu gcaacaccgc ccugcugauc     1740

gugaccaucg uggugaucau gcuggugcug ggccuggccg uggccuucug cugccugcac     1800

uucgaccugc ccugguaccu gagaaugcug ggccagugca cccagaccug gcacagagug     1860

agaaagacca cccaggagca gcugaagaga aacgugagau uccacgccuu caucagcuac     1920

agcgagcacg acagccugug ggugaagaac gagcugaucc ccaaccugga gaaggaggac     1980

ggcagcaucc ugaucugccu guacgagagc uacuucgacc ccggcaagag caucagcgag     2040

aacaucguga gcuucaucga gaagagcuac aagagcaucu ucgugcugag ccccaacuuc     2100

gugcagaacg aguggugcca cuacgaguuc uacuucgccc accacaaccu guuccacgag     2160

aacagcgacc acaucauccu gauccugcug gagcccaucc ccuucuacug cauccccacc     2220

agauaccaca agcugaaggc ccugcuggag aagaaggccu accuggagug gcccaaggac     2280

agaagaaagu gcggccuguu cugggccaac cugagagccg ccaucaacgu gaacgugcug     2340

gccaccagag agauguacga gcugcagacc uucaccgagc ugaacgagga gagcagaggc     2400

agcaccauca gccugaugag aaccgacugc cuguga                               2436


<210>  9507
<211>  2436
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR10__Homo_sapiens__AAH89406

<400>  9507
augagacuga uccggaacau uuacaucuuc ugcagcauug ugaugaccgc cgagggcgac       60

gcucccgaac ucccugagga acgcgagcug augacaaauu guuccaacau gucucuuaga      120

aaggucccgg ccgaucugac gcccgcgacc acaacccucg accugagcua uaaucuucug      180

uuucagcucc aauccucuga uuuccacagc guuuccaaac ugcgggugcu gauccucugc      240

cauaaccgca uucagcagcu ggaccuuaag acauuugagu ucaauaaaga acugagauac      300

cucgaucugu cuaacaaucg gcuuaagagc gugaccuggu aucugcucgc ugggcugcgc      360

uaccuggacc ucuccuuuaa cgauuucgac acaaugccua ucugugagga agccggaaau      420

augagccacc uggagauccu uggccugucu ggggccaaaa uucagaaguc cgauuuucaa      480

aagaucgcuc aucuccaccu gaacaccguc uuccuuggau uuagaacgcu gccccauuau      540

gaagagggca gccucccuau ucugaauacc acaaaacugc acaucgugcu ccccauggac      600

accaacuucu ggguucugcu ucgggauggg auuaagacau cuaaaauccu ggagaugacc      660

aauauugacg gaaaguccca guuugugagc uacgaaaugc agcgcaaccu cucucuggag      720

aaugccaaaa cguccguccu ucugcucaac aagguggauc ugcuguggga cgaccucuuc      780

cugauccuuc aguuuguuug gcacacaagc guggaacauu uccaaaucag aaacgucacc      840

uucggcggca aggcuuaucu ggaucacaau uccuuugacu acucuaacac agugaugcgg      900

accauuaaac ucgagcaugu gcacuuccgc gucuuuuaca uccagcagga uaagauuuau      960

cugcugcuua ccaaaaugga caucgaaaau cucacaauua gcaacgccca gaugccucac     1020

augcuguucc cgaauuaccc cacgaaguuu caauaucuga acuucgcgaa uaacauccuc     1080

accgaugagc uguuuaaaag aacaauccag cuuccucauc ugaagacccu cauucugaau     1140

gggaacaaac uggagacacu uucccucguu agcugcuucg ccaauaacac gccccuggaa     1200

caccuggacc ucucucagaa ucugcuucaa cauaagaacg augagaauug uuccuggccu     1260

gaaaccgugg ugaacaugaa ccugagcuac aauaagcucu cugacagcgu cuuucggugc     1320

cugcccaaau ccauccagau ucuggaucuu aacaauaacc agauccagac agugccgaag     1380

gagaccauuc accucauggc ucugcgcgaa cugaauaucg ccuucaacuu ucucaccgac     1440

cugccuggau guucucauuu cagcagacuu uccguucuga auaucgagau gaacuuuauu     1500

cucagccccu cucuggauuu cgugcaaucc ugccaggagg ucaaaacacu gaaugcuggc     1560

cggaacccuu ucagauguac cugcgaacuu aagaauuuua uccagcucga gacauauagc     1620

gaagugauga ugguugggug gucugacucc uacacgugug aguauccccu gaaccugcgc     1680

ggaacccggc ucaaagacgu gcaccuucac gaacuuagcu gcaauacagc ccugcucauu     1740

gucaccaucg uggucauuau gcuggugcug ggccuugcgg uugccuucug cugucugcau     1800

uuugaucucc ccugguaccu gagaaugcuc gggcagugca cacaaaccug gcaccgcgug     1860

cggaagacga cccaggagca gcugaagaga aacguccgcu uccaugcuuu uaucuccuac     1920

ucugagcacg acagccuuug ggugaaaaau gaacugauuc cuaaccucga gaaggaagau     1980

ggauccaucc ugaucugucu guaugagucu uacuucgacc cgggcaaaag cauuuccgag     2040

aacaucguua gcuuuauuga aaagucuuau aaauccaucu ucgugcuuag ccccaauuuu     2100

guccagaacg aguggugcca cuacgaguuc uauuuugccc aucacaaucu guuccaugaa     2160

aacucugauc acauuauccu cauccugcuc gaaccuauuc ccuuuuacug uaucccuaca     2220

cgguaucaua agcugaaggc ucugcuggag aaaaaggccu accucgagug gcccaaagac     2280

agacgcaagu gcggccuguu cugggccaau cugcgggcug cgauuaacgu gaaugugcuu     2340

gccaccagag aaauguacga gcugcaaaca uucaccgaac ucaacgagga aucccgcggg     2400

agcacgaucu cucugaugcg gacagauugu cucuga                               2436


<210>  9508
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS34

<400>  9508

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9509
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85633

<400>  9509
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9510
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85633

<400>  9510
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9511
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85633

<400>  9511
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9512
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85633

<400>  9512
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaauagc      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucacugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugcaucuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacac cucacugagc uggaaacacu uauccugcag     1140

augaaucagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaua guaauaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa acguggcuuu caauagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucaucau ugaccacaac     1500

uccgugaguc aucccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca acccuuuuca augcacaugu gagcugggug aguucguaaa gaauauagau     1620

cagguuucaa gugaagugcu agaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucugcu caaagauuuu cacauguccg aacugucuug caacaucacc     1740

cuuuugauug ucacaaucgu ggcuacuaug cuggucuuag ccgugaccgu uacaagccuc     1800

uguauuuacc uggaccuucc uugguaucug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaauauccc auuggaggag cuccaaagga accugcaguu ccacgcauuu     1920

auaucauaca guggacauga uuccuucugg guaaagaaug aacuacugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cggaauuuug ucccggguaa gucuaucgug     2040

gagaacauua ucacgugcau agaaaaaucg uauaagucca ucuucguucu uucaccuaau     2100

uuugugcaga gcgaguggug ucauuacgaa uuguacuucg cccaccacaa ccuguuucau     2160

gaggggagua auucuuuaau ucucauccug cuugaaccca uuccacaaua uuccaucccu     2220

agcucguacc acaagcugaa aucacuaaug gcucgucgca cauaucucga guggcccaag     2280

gagaaaucua agagaggacu guucugggcc aacuugaggg cagcuauaaa uauuaaacug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9513
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85633

<400>  9513
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9514
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85633

<400>  9514
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaauagc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaac      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucaccaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cuccaucugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccac cucacagagc uggaaacgcu gauucuccag     1140

augaaucagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acauuuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccauu cuaauaagau caaauccauu     1380

cccaagcaag ucgugaaacu ggaagcccuu caggagcuga acguugcuuu caauagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuaucau ugaccacaac     1500

agcgucuccc aucccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca acccguuuca augcacaugu gagcucggag aguucgugaa gaauauugau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccugcu caaagauuuu cacauguccg aacugucuug caacaucacc     1740

cuucugaucg uuacaauugu ggccaccaug cucguccugg cugugacagu uacgagccug     1800

uguaucuacc uugaccuccc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaauauucc ccuggaggag cuccaacgga accugcaguu ccacgcuuuu     1920

aucuccuacu cuggacauga uagcuucugg gucaagaaug aacuucugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cgcaauuuug ugccuggcaa guccaucgug     2040

gagaacauca uuaccugcau cgaaaagagc uauaagucua uuuucguucu guccccgaau     2100

uuuguccaga gcgaguggug ucauuacgaa cuuuacuucg cccaccacaa ccuguuucau     2160

gaggggucua auucccucau ccugauucuc cuggaaccca ucccucaaua uagcaucccc     2220

ucuuccuacc acaaacuuaa aagccugaug gcgagacgga cauaucucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaccugcgcg cugccauuaa uaucaaacuu     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9515
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS35

<400>  9515

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Ser Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9516
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85634

<400>  9516
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaagccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9517
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85634

<400>  9517
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cugagcgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugacgga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggucccuccu gaaggacuuc cacaugagcg agcuguccug caacaucacc     1740

cuccugaucg ugaccaucgu cgccaccaug cuggugcucg ccgugacggu caccagccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacccgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucuccuaca gcggccacga cuccuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccgggcaa gagcaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cucccccaac     2100

uucguccaga gcgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gaggggucca acagccucau ccugauccug cucgagccca ucccccagua cuccaucccg     2220

agcagcuacc acaagcugaa gucccugaug gcccgccgga ccuaccucga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9518
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85634

<400>  9518
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcucccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9519
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85634

<400>  9519
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaacucg      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaau      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucacugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugcaucuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacac cucacugagc uggaaacacu uauccugcag     1140

augaaucagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaua guaauaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa acguggcuuu caauagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucaucau ugaccacaac     1500

uccgugaguc aucccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca acccuuuuca augcacaugu gagcugggug aguucguaaa gaauauagau     1620

cagguuucaa gugaagugcu agaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggucccugcu caaagauuuu cacaugucug aacugagcug caacaucacu     1740

cuuuugauug ucaccaucgu ggcuacaaug cuggucuuag ccgugacugu uaccucacuc     1800

uguauuuacc uggaccuucc uugguaucug aggauggugu gccaguggac acagacccgg     1860

cgccgagcga gaaauauccc auuggaggag cuccaaagga accugcaguu ccacgcauuu     1920

auaaguuacu ccggacauga uucuuucugg guaaagaaug aacuacugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cggaauuuug ucccggguaa gagcaucgug     2040

gagaacauua ucacuugcau agaaaaaucc uauaagucaa ucuucguucu uagcccuaau     2100

uuugugcaga gugaguggug ucauuacgaa uuguacuucg cccaccacaa ccuguuucau     2160

gaggggucua auuccuuaau ucucauccug cuugaaccca uuccacaaua uagcaucccu     2220

ucgucauacc acaagcugaa aucucuaaug gcucgucgca cguaucucga guggcccaag     2280

gagaaaagua agagaggacu guucugggcc aacuugaggg cagcuauaaa uauuaaacug     2340

acagaacagg ccaagaaaug a                                               2361


<210>  9520
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85634

<400>  9520
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcagccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9521
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85634

<400>  9521
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaauagc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaac      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucaccaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cuccaucugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccac cucacagagc uggaaacgcu gauucuccag     1140

augaaucagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acauuuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccauu cuaauaagau caaauccauu     1380

cccaagcaag ucgugaaacu ggaagcccuu caggagcuga acguugcuuu caauagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuaucau ugaccacaac     1500

agcgucuccc aucccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca acccguuuca augcacaugu gagcucggag aguucgugaa gaauauugau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggucccugcu caaagauuuu cacaugucug aacugagcug caacaucacc     1740

cuucugaucg uuaccauugu ggccacaaug cucguccugg cugugaccgu uacaucccug     1800

uguaucuacc uugaccuccc uugguaucug cgcauggugu gccaguggac gcagaccaga     1860

cggcgcgcca gaaauauucc ccuggaggag cuccaacgga accugcaguu ccacgcuuuu     1920

aucucuuaca gcggacauga uuccuucugg gucaagaaug aacuucugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cgcaauuuug ugccuggcaa gagcaucgug     2040

gagaacauca uuacaugcau cgaaaaaucu uauaagucca uuuucguucu gagcccgaau     2100

uuuguccagu cugaguggug ucauuacgaa cuuuacuucg cccaccacaa ccuguuucau     2160

gaggggucca auagccucau ccugauucuc cuggaaccca ucccucaaua uucuaucccc     2220

uccagcuacc acaaacuuaa gucccugaug gcgagacgga ccuaucucga guggccuaag     2280

gagaaaagca agagaggacu guucugggcc aaccugcgcg cugccauuaa uaucaaacuu     2340

acagaacagg cuaagaaaug a                                               2361


<210>  9522
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS36

<400>  9522

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Ala Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9523
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85635

<400>  9523
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caagcaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9524
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85635

<400>  9524
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggccucca gcgagguccu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu ggccacgaug cugguccucg ccgugaccgu gaccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggucu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgcguuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ugccggggaa guccaucguc     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucgugcagu ccgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgcgaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9525
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85635

<400>  9525
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggccuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9526
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85635

<400>  9526
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaauagc      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucacugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugcaucuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacac cucacugagc uggaaacacu uauccugcag     1140

augaaucagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaua guaauaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa acguggcuuu caauagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucaucau ugaccacaac     1500

uccgugaguc aucccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca acccuuuuca augcacaugu gagcugggug aguucguaaa gaauauagau     1620

caggcuucaa gugaaguucu agaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucugcu caaagauuuu cacauguccg aacugucuug caacaucacc     1740

cuuuugauug ugacaaucgu cgccacuaug cugguguuag cggucaccgu gacaagccuc     1800

uguauuuacc uggaccuucc uugguaucug aggaugguuu gccaguggac ccagacucgg     1860

cgccgagcaa gaaauauccc auuggaggag cuccaaagga accugcaguu ccacgccuuu     1920

auaucauaca guggacauga uuccuucugg gugaagaaug aacuacugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cggaauuuug uaccggguaa gucuaucguc     2040

gagaacauua ucacgugcau agaaaaaucg uauaagucca ucuucgugcu uucaccuaau     2100

uuuguucaga gcgaguggug ucauuacgaa uuguacuucg cucaccacaa ccuguuucau     2160

gaggggagua auucuuuaau ucucauccug cuugaaccca uuccacaaua uuccaucccu     2220

agcucguacc acaagcugaa aucacuaaug gcccgucgca cauaucucga guggcccaag     2280

gagaaaucua agagaggacu guucugggca aacuugaggg cugccauaaa uauuaaacug     2340

accgaacagg cgaagaaaug a                                               2361


<210>  9527
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85635

<400>  9527
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggccagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9528
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85635

<400>  9528
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaauagc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaac      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucaccaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cuccaucugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccac cucacagagc uggaaacgcu gauucuccag     1140

augaaucagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acauuuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccauu cuaauaagau caaauccauu     1380

cccaagcaag ucgugaaacu ggaagcccuu caggagcuga acguugcuuu caauagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuaucau ugaccacaac     1500

agcgucuccc aucccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca acccguuuca augcacaugu gagcucggag aguucgugaa gaauauugau     1620

caggccagcu ccgaaguccu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccugcu caaagauuuu cacauguccg aacugucuug caacaucacc     1740

cuucugaucg ugacaauugu ugcuaccaug cucgugcugg ccgucacagu gacgagccug     1800

uguaucuacc uugaccuccc uugguaucug cgcaugguuu gccaguggac ccagacaaga     1860

cggcgcgcua gaaauauucc ccuggaggag cuccaacgga accugcaguu ccacgccuuu     1920

aucuccuacu cuggacauga uagcuucugg gugaagaaug aacuucugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcacgag cgcaauuuug ucccuggcaa guccaucgug     2040

gagaacauca uuaccugcau cgaaaagagc uauaagucua uuuucgugcu guccccgaau     2100

uuuguucaga gcgaguggug ucauuacgaa cuuuacuucg cgcaccacaa ccuguuucau     2160

gaggggucua auucccucau ccugauucuc cuggaaccca ucccucaaua uagcaucccc     2220

ucuuccuacc acaaacuuaa aagccugaug gccagacgga cauaucucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcu aaccugcgcg ccgcuauuaa uaucaaacuu     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9529
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS38

<400>  9529

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Ile Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9530
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85637

<400>  9530
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguauac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9531
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85637

<400>  9531
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acgggcucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugcaucc cgccccgcau caaggugcuc gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu ggaggcccuc caggagcuga acguggccuu caacagccug     1440

accgaccucc ccgggugcgg cuccuucagc ucccugagcg uccugaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcucgggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccugcu caaggacuuc cacauguccg agcugagcug caacaucacc     1740

cugcucaucg ugaccaucgu cgccacgaug cuggugcugg ccgugaccgu caccucccuc     1800

ugcaucuacc uggaccugcc cugguaccuc cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cugcagcgca accuccaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcugcc caaccucgag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu gagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccugau ccucauccug cuggagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccugcggg ccgccaucaa caucaagcug     2340

accgagcagg cgaagaagug a                                               2361


<210>  9532
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85637

<400>  9532
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugcaucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9533
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85637

<400>  9533
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaacucg      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaau      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac aagucugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugcaucuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacac cucacugagc uggaaacacu uauccugcag     1140

augaaucagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgauuuuu     1320

agguguauac ccccucggau caagguccuu gacuugcaua guaauaagau uaaaucuauc     1380

ccaaagcaag ugguuaaacu ggaagcccuc caggagcuga acguggcuuu caauagcuua     1440

accgaucugc cgggcugcgg guccuuuuca agccuuucug ucuugauuau cgaccacaac     1500

uccgugaguc aucccagcgc agauuucuuc cagucuuguc agaagaugcg cuccauaaaa     1560

gccggagaca acccuuuuca augcacaugu gagcucggug aguucguaaa gaauaucgau     1620

cagguuucaa gugaagugcu ggaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucuacu gaaagauuuu cacauguccg aacucucuug caacauuacc     1740

cugcuuaucg ucacaauugu ggcuacuaug uugguccugg ccgugaccgu uacuagcuua     1800

uguaucuacc ucgaccugcc uugguaucuu aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaauauacc acuggaggag uugcaaagga accuccaguu ccacgcauuu     1920

auuucauaca guggacauga uuccuucugg guaaagaaug aacugcuacc caaccuggag     1980

aaagaaggca ugcagaucug ucuccacgag cggaauuuug ucccggguaa gucuauugug     2040

gagaacauca uaacgugcau cgaaaagagc uauaagucca uuuucguucu gucaccuaau     2100

uuugugcaga gcgaguggug ucauuacgaa cuuuacuucg cccaccacaa cuuguuucau     2160

gaggggagua auucucugau cuuaauucuc cuggaaccca ucccacaaua uuccauaccu     2220

agcucguacc acaaacuuaa aucacugaug gcucgucgca cauaucuaga guggcccaag     2280

gagaaaucua agagaggacu cuucugggcc aaccugaggg cagcuauuaa uaucaaauug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9534
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85637

<400>  9534
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugcaucc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9535
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85637

<400>  9535
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau cagaauccaa       60

cuguccgagg aaucugaguu ucuuguggac cggagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauaucag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaacucc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaau      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucaccaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cuccaucugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccac cucacagagc uggaaacgcu gauucuccag     1140

augaaucagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaaaagccug     1200

cagcagcucg acauuuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uccucacaga uaccauuuuu     1320

cgguguauuc ccccucgcau caaggugcug gaccugcauu cuaauaagau uaaauccauc     1380

cccaagcaag ucgugaaacu cgaagcccug caggagcuua acguugcuuu caauagccug     1440

acggaucucc cuggaugcgg cucuuuuucc agccugucug ugcugauuau cgaccacaac     1500

agcgucuccc aucccagcgc cgauuucuuc cagucuuguc agaagaugag auccauuaaa     1560

gcgggggaca acccguuuca augcacaugu gagcuuggag aguucgugaa gaauaucgau     1620

caggucagcu ccgaagugcu cgaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccugcu gaaagauuuu cacauguccg aacucucuug caacaucacc     1740

cugcuuauug uuacaaucgu ggccaccaug cugguccucg cugugacagu uacgagccug     1800

uguauuuacc uggaccuucc uugguaucuc cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaauauccc ccuggaggag cugcaacgga accuccaguu ccacgcuuuu     1920

auuuccuacu cuggacauga uagcuucugg gucaagaaug aacugcuucc caaccuggag     1980

aaagaaggca ugcagaucug ucuccacgag cgcaauuuug ugccuggcaa guccaucgug     2040

gagaacauua uuaccugcau ugaaaagagc uauaagucua ucuucguucu guccccgaau     2100

uuuguccaga gcgaguggug ucauuacgaa cuguacuucg cccaccacaa ccuuuuucau     2160

gaggggucua auucccugau ucucauccug cucgaaccca ucccucaaua uagcauuccc     2220

ucuuccuacc acaagcugaa aagccuuaug gcgagacgga cauaucugga guggccuaag     2280

gagaaaucca agagaggacu cuucugggcc aaccugcgcg cugccaucaa uauuaaacug     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9536
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS42

<400>  9536

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys Tyr Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9537
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85641

<400>  9537
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa guacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9538
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85641

<400>  9538
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa guaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9539
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85641

<400>  9539
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa guaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9540
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85641

<400>  9540
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa guaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucau cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuacggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaca uuguuuuucc uaccaauaag      600

gaguuccauu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuauuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaauagc      780

uucauacgaa uuuugcaacu cguuuggcac accacagugu gguacuuuuc uaucuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu auucaggcac uucacugaag      900

gcccuaagca uccaucaggu gguguccgac gucuucgguu uuccccaauc uuacauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugcaccuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacau cucacugagc uggaaacacu uauccugcag     1140

augaaucagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaacagcgug uccuaugaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaca guaauaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa acguggcuuu caauagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucaucau ugaccauaac     1500

uccgugaguc accccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca acccuuuuca augcacaugu gagcugggug aguucguaaa gaauauagau     1620

cagguuucaa gugaagugcu agaaggcugg ccagacagcu acaagugcga cuaucccgag     1680

ucguacagag ggacucugcu caaagauuuu cauauguccg aacugucuug caacaucacc     1740

cuuuugauug ucacaaucgu ggcuacuaug cuggucuuag ccgugaccgu uacaagccuc     1800

uguauuuauc uggaccuucc uugguaccug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaauauccc auuggaggag cuccaaagga accugcaguu ccacgcauuu     1920

auaucauaua guggacacga uuccuucugg guaaagaaug aacuacugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcaugag cggaauuuug ucccggguaa gucuaucgug     2040

gagaacauua ucacgugcau agaaaaaucg uacaagucca ucuucguucu uucaccuaau     2100

uuugugcaga gcgaguggug ucacuacgaa uuguauuucg cccaucacaa ccuguuucac     2160

gaggggagua auucuuuaau ucucauccug cuugaaccca uuccacaaua cuccaucccu     2220

agcucguauc auaagcugaa aucacuaaug gcucgucgca cauaccucga guggcccaag     2280

gagaaaucua agagaggacu guucugggcc aacuugaggg cagcuauaaa uauuaaacug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9541
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85641

<400>  9541
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa guaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9542
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85641

<400>  9542
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa guaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacau cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuacgggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaca ucguguuucc caccaauaag      600

gaguuccauu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuauuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaauagc      780

uucauccgga uucuccaacu ggucuggcac accacggugu gguacuuuag caucucuaac      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu auagcgggac aucccugaag      900

gcccuuucua uucaucaggu cguuagcgac guguucggau uuccccaauc cuacaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cuccaccugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccau cucacagagc uggaaacgcu gauucuccag     1140

augaaucagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acauuuccca gaacucuguu agcuaugaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccacu cuaauaagau caaauccauu     1380

cccaagcaag ucgugaaacu ggaagcccuu caggagcuga acguugcuuu caauagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuaucau ugaccauaac     1500

agcgucuccc accccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca acccguuuca augcacaugu gagcucggag aguucgugaa gaauauugau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu acaagugcga cuaucccgag     1680

agcuaccggg ggacccugcu caaagauuuu cauauguccg aacugucuug caacaucacc     1740

cuucugaucg uuacaauugu ggccaccaug cucguccugg cugugacagu uacgagccug     1800

uguaucuauc uugaccuccc uugguaccug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaauauucc ccuggaggag cuccaacgga accugcaguu ccacgcuuuu     1920

aucuccuauu cuggacacga uagcuucugg gucaagaaug aacuucugcc caaccucgag     1980

aaagaaggca ugcagauuug ucugcaugag cgcaauuuug ugccuggcaa guccaucgug     2040

gagaacauca uuaccugcau cgaaaagagc uacaagucua uuuucguucu guccccgaau     2100

uuuguccaga gcgaguggug ucacuacgaa cuuuauuucg cccaucacaa ccuguuucac     2160

gaggggucua auucccucau ccugauucuc cuggaaccca ucccucaaua cagcaucccc     2220

ucuuccuauc auaaacuuaa aagccugaug gcgagacgga cauaccucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaccugcgcg cugccauuaa uaucaaacuu     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9543
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS43

<400>  9543

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


Leu Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9544
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85642

<400>  9544
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccauguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacuccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9545
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85642

<400>  9545
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccugcaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcucugcc ccagcaagau cuccccguuc cugcaccugg acuucagcaa caaccugcuc     1080

accgacaccg uguucgagaa cugcgggcac cugacggagc uggagacccu cauccugcag     1140

augaaccagc ugaaggagcu cuccaagauc gcggagauga ccacccagau gaagucccug     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccuccuguc ccugaacaug agcuccaaca uccucaccga caccaucuuc     1320

cggugccugc cgccccgcau caaggugcug gaccuccaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu ggaggcccug caggagcuca acguggccuu caacagccug     1440

accgaccugc ccgggugcgg cuccuucagc ucccucagcg uccugaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu cgagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccugcu gaaggacuuc cacauguccg agcucagcug caacaucacc     1740

cugcugaucg ugaccaucgu cgccacgaug cucgugcugg ccgugaccgu caccucccug     1800

ugcaucuacc ucgaccugcc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccucgaggag cugcagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcuccugcc caaccuggag     1980

aaggagggca ugcagaucug ccuccacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu gagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccucuuccac     2160

gagggcagca acucccugau ccugauccuc cuggagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccuccggg ccgccaucaa caucaagcug     2340

accgagcagg cgaagaagug a                                               2361


<210>  9546
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85642

<400>  9546
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccuccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9547
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85642

<400>  9547
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaauagu      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucgcugaag      900

gcccuaagca uccuccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcugugcc cuaguaagau auccccauuc cuucacuugg acuuuagcaa caaucugcuc     1080

accgauacgg uauucgagaa cuguggacau cugacugagc uugaaacacu gaucuugcag     1140

augaaucagc ucaaggagcu gucuaaaauu gcagaaauga ccacucaaau gaagucauua     1200

cagcagcugg acaucaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcuacucag ccugaauaug uccucaaaca uccuuaccga uacgauuuuu     1320

agguguuugc ccccucggau aaagguccug gaccuccaca guaauaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu ggaagccuua caggagcuga acguggcuuu caauagccuu     1440

accgauuugc cgggcugcgg guccuuuuca agccucucug uccugaucau ugaccauaac     1500

uccgugaguc accccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca acccuuuuca augcacaugu gagcuaggug aguucguaaa gaauauagau     1620

cagguuucaa gugaagugcu ggaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucuccu gaaagauuuu cauauguccg aacuuucuug caacaucacc     1740

uugcugauug ucacaaucgu ggcuacuaug uuaguccucg ccgugaccgu uacaagccug     1800

uguauuuacc uugaccugcc uugguauuug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaauauccc acucgaggag cugcaaagga accuacaguu ccacgcauuu     1920

auaucauaca guggacacga uuccuucugg guaaagaaug aacugcuccc caaccuggag     1980

aaagaaggca ugcagauuug ucuucaugag cggaauuuug ucccggguaa gucuaucgug     2040

gagaacauua ucacgugcau agagaaaagc uauaagucca ucuucguuuu gucaccuaau     2100

uuugugcaga gcgaauggug ucacuacgaa cuguacuucg cccaucacaa cuuauuucac     2160

gaggggagua auucucucau ucugauccuu cuggaaccca uuccacaaua uuccaucccu     2220

agcucguacc auaagcuaaa aucacucaug gcucgucgca cauaucugga guggcccaag     2280

gagaaaucua agagaggauu guucugggcc aaccugaggg cagcuauaaa uauuaaauua     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9548
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85642

<400>  9548
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccugcaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9549
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85642

<400>  9549
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaacucc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaau      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucugcaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcucugcc cuuccaagau cagcccguuc cugcaccugg acuuuucuaa caaucuucuc     1080

accgauaccg uguucgagaa cuguggccau cugacagagc uggaaacgcu cauucugcag     1140

augaaucagc uuaaggagcu guccaaaauc gcugaaauga ccacacaaau gaaaagccuc     1200

cagcagcugg acauuuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcuuag ccucaauaug uccagcaaca uccugacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcuc gaccugcacu cuaauaagau caaauccauu     1380

cccaagcaag ucgugaaacu ugaagcccug caggagcuca acguugcuuu caauagccug     1440

acggaucugc cuggaugcgg cucuuuuucc agccuuucug ugcucaucau ugaccauaac     1500

agcgucuccc accccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca acccguuuca augcacaugu gagcugggag aguucgugaa gaauauugau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccuccu gaaagauuuu cauauguccg aacuuucuug caacaucacc     1740

cugcucaucg uuacaauugu ggccaccaug cugguccugg cugugacagu uacgagccuu     1800

uguaucuacc ucgaccugcc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaauauucc ccucgaggag cugcaacgga accuucaguu ccacgcuuuu     1920

aucuccuacu cuggacacga uagcuucugg gucaagaaug aacugcuccc caaccuggag     1980

aaagaaggca ugcagauuug ucugcaugag cgcaauuuug ugccuggcaa guccaucgug     2040

gagaacauca uuaccugcau cgaaaagagc uauaagucua uuuucguucu uuccccgaau     2100

uuuguccaga gcgaguggug ucacuacgaa cuguacuucg cccaucacaa ccucuuucac     2160

gaggggucua auucccugau ccucauucug cuugaaccca ucccucaaua uagcaucccc     2220

ucuuccuacc auaagcugaa aagccucaug gcgagacgga cauaucugga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaccuucgcg cugccauuaa uaucaaacug     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9550
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__D1CS44

<400>  9550

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Met Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9551
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAY85643

<400>  9551
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau gucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9552
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAY85643

<400>  9552
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau gagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9553
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAY85643

<400>  9553
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau guccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9554
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAY85643

<400>  9554
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau guccgaacua      180

uggacgucug acauccucuc gcugucaaaa cuucggauuc ugaucauuag ccacaaucgc      240

auccaguauu uggauauaag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gauuucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca aucuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgauugcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua ucguuuuucc uaccaauaag      600

gaguuccacu uuauucucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

auaaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauccu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca uugagacgac uuggaauagc      780

uucauccgaa uauugcaacu cguuuggcau accacagugu gguauuuuuc uauuuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucacugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauaucuac      960

gaaauuuuca gcaauaugaa caucaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau uuccccauuc cugcaucuug acuuuagcaa caauuugcug     1080

accgauacgg uauucgagaa cuguggacac cucacugagc uggaaacacu uauacugcag     1140

augaaucagu ugaaggagcu cucuaaaauc gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acauuaguca gaacagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaauaug uccucaaaca uccugaccga uacgaucuuu     1320

aggugucuuc ccccucggau uaaggucuug gaccugcaua guaauaagau aaaaucuauc     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa acguggcuuu caauagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucauuau cgaccacaac     1500

uccgugaguc aucccagcgc agauuucuuc cagucuuguc agaagaugcg cuccauuaaa     1560

gccggagaca acccuuuuca augcacaugu gagcugggug aguucguaaa gaauaucgau     1620

cagguuucaa gugaagugcu agaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucugcu caaagauuuu cacauguccg aacugucuug caacauaacc     1740

cuuuugaucg ucacaauugu ggcuacuaug cuggucuuag ccgugaccgu uacaagccuc     1800

uguaucuacc uggaccuucc uugguaucug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaauauucc auuggaggag cuccaaagga accugcaguu ccacgcauuu     1920

aucucauaca guggacauga uuccuucugg guaaagaaug aacuacugcc caaccucgag     1980

aaagaaggca ugcagauaug ucugcacgag cggaauuuug ucccggguaa gucuauugug     2040

gagaacauca uuacgugcau cgaaaaaucg uauaagucca uauucguucu uucaccuaau     2100

uuugugcaga gcgaguggug ucauuacgaa uuguacuucg cccaccacaa ccuguuucau     2160

gaggggagua auucuuuaau ccucauucug cuugaaccca ucccacaaua uuccauuccu     2220

agcucguacc acaagcugaa aucacuaaug gcucgucgca cauaucucga guggcccaag     2280

gagaaaucua agagaggacu guucugggcc aacuugaggg cagcuaucaa uauaaaacug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9555
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAY85643

<400>  9555
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau gagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9556
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAY85643

<400>  9556
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau cagaauccaa       60

cuguccgagg aaucugaguu ucuuguggac cggagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau gagcgaacuu      180

uggaccuccg acauccuguc ucucagcaaa cugcgcauuc ugaucauuuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg aucuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccauugcg      480

caccugaaua ucuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua uuguguuucc caccaauaag      600

gaguuccacu uuauccugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

auuaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca ucgagaccac auggaauagc      780

uucauucgga uccuccaacu ggucuggcau accacggugu gguauuuuag cauuucuaac      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uccaccaggu cguuagcgac guguucggau uuccccaauc cuauauuuac      960

gaaaucuuca gcaauaugaa caucaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau uagcccguuc cuccaucugg acuuuucuaa caaucugcuu     1080

accgauaccg uguucgagaa cuguggccac cucacagagc uggaaacgcu gauccuccag     1140

augaaucagc ugaaggagcu uuccaaaauu gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acaucuccca gaacucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaauaug uccagcaaca uucucacaga uaccaucuuu     1320

cggugucugc ccccucgcau uaaggugcug gaccuccauu cuaauaagau caaauccauc     1380

cccaagcaag ucgugaaacu ggaagcccuu caggagcuga acguugcuuu caauagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuauuau cgaccacaac     1500

agcgucuccc aucccagcgc cgauuucuuc cagucuuguc agaagaugag auccauuaaa     1560

gcgggggaca acccguuuca augcacaugu gagcucggag aguucgugaa gaauaucgau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccugcu caaagauuuu cacauguccg aacugucuug caacauuacc     1740

cuucugaucg uuacaaucgu ggccaccaug cucguccugg cugugacagu uacgagccug     1800

uguauuuacc uugaccuccc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaauauccc ccuggaggag cuccaacgga accugcaguu ccacgcuuuu     1920

auuuccuacu cuggacauga uagcuucugg gucaagaaug aacuucugcc caaccucgag     1980

aaagaaggca ugcagaucug ucugcacgag cgcaauuuug ugccuggcaa guccauugug     2040

gagaacauca uuaccugcau ugaaaagagc uauaagucua ucuucguucu guccccgaau     2100

uuuguccaga gcgaguggug ucauuacgaa cuuuacuucg cccaccacaa ccuguuucau     2160

gaggggucua auucccucau ucugauccuc cuggaaccca uuccucaaua uagcaucccc     2220

ucuuccuacc acaaacuuaa aagccugaug gcgagacgga cauaucucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaccugcgcg cugccaucaa uauuaaacuu     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9557
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__Q15399

<400>  9557

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Asn Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ser Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9558
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAI09094

<400>  9558
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aaaucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucggc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcagcuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9559
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAI09094

<400>  9559
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac caccauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag caaccucacc cugaacaaca ucgagaccac guggaacucc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucag caucuccaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acagcggcac cucccucaag      900

gcccugagca uccaccaggu cguguccgac guguucgggu ucccccagag cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucacgguca gcggcacccg cauggugcac     1020

augcugugcc ccuccaagau cagcccguuc cuccaccugg acuucuccaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu gagcaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc uccuacgacg agaagaaggg cgacugcagc     1260

uggacgaagu cccugcucag ccugaacaug uccagcaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcacu ccaacaagau caagagcauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacucccuc     1440

accgaccugc ccgggugcgg cagcuucucc agccuguccg uccucaucau cgaccacaac     1500

agcguguccc accccagcgc cgacuucuuc caguccugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucagcu ccgaggugcu ggagggcugg cccgacagcu acaagugcga cuacccggag     1680

uccuaccgcg ggacccuccu gaaggacuuc cacaugagcg agcuguccug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccagccug     1800

ugcuccuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9560
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAI09094

<400>  9560
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc caaccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcuccuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9561
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAI09094

<400>  9561
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc caaccuuacc cugaacaaua ucgagacgac uuggaacagc      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc gaucucuaau      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acuccggcac uucacugaag      900

gcccuaagua uccaccaggu ggugagcgac gucuucgguu uuccccaauc cuauauuuac      960

gaaaucuucu cuaacaugaa uauuaaaaac uuuaccguua gcgggacaag aauggugcac     1020

augcucugcc cuucaaagau aaguccauuc cugcaucuug acuuuuccaa uaacuugcug     1080

accgauacgg uauucgagaa uuguggacac cucacugagc uggaaacacu uauccugcag     1140

augaaccagu ugaaggagcu cagcaaaauu gcagaaauga ccacucaaau gaagucucug     1200

cagcaguuag acaucucaca gaauagugug agcuacgaug agaaaaaggg cgacugcucc     1260

uggacaaaau cucugcuauc gcucaacaug agcuccaaua uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcauu caaacaagau caaaaguauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa auguggcuuu caacucucug     1440

accgaucuuc cgggcugcgg gagcuuuucc ucauugagcg uccucaucau ugaccacaac     1500

ucuguguccc aucccagugc agauuucuuc cagagcuguc agaagaugcg cucuaucaaa     1560

gccggagaca auccuuuuca augcacaugu gagcugggug aguucguaaa gaacauagau     1620

cagguuuccu cagaagugcu agaaggcugg ccagacaguu auaagugcga cuaccccgag     1680

agcuauagag ggacucugcu caaagauuuu cacaugucgg aacuguccug caauaucacc     1740

cuuuugauug ucacaaucgu ggcuacuaug cuggucuuag ccgugaccgu uacaucucuc     1800

uguagcuacc uggaccuucc uugguaucug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaacauucc auuggaggag cuccaaagga aucugcaguu ccacgcauuu     1920

aucucauaca guggacauga uuccuucugg guaaagaacg aacuacugcc caaucucgag     1980

aaagaaggca ugcagauaug ucugcacgag cggaacuuug ucccggguaa gucuauugug     2040

gagaauauca uuacgugcau cgagaaaagc uauaagucca uauucguucu uucaccuaac     2100

uuugugcaga gcgaauggug ucauuacgaa uuguacuucg cccaccacaa ucuguuucau     2160

gaggggagua acucuuuaau ccucauucug cuugaaccca ucccacaaua uuccauuccu     2220

agcucguacc acaagcugaa aucacuaaug gcucgucgca cauaucucga guggcccaag     2280

gagaaaucua agagaggacu guucugggcc aauuugaggg cagcuaucaa cauaaaacug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9562
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAI09094

<400>  9562
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag caaccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcagcuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9563
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAI09094

<400>  9563
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauaucag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag caaccuuaca cugaacaaua uugagaccac auggaacucu      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuuc caucagcaau      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acucugggac aagccugaag      900

gcccuuucca uucaccaggu cguuucugac guguucggau uuccccaaag cuauaucuac      960

gaaaucuucu ccaacaugaa uauuaaaaac uuuaccguga gcggcacaag aaugguccac     1020

augcugugcc cuucuaagau cuccccguuc cuccaucugg acuuuagcaa uaaccugcuu     1080

accgauaccg uguucgagaa uuguggccac cucacagagc uggaaacgcu gauucuccag     1140

augaaccagc ugaaggagcu uucuaaaauc gcugaaauga ccacacaaau gaagucccug     1200

cagcagcucg acauuagcca aaauuccguu ucuuacgaug agaaaaaggg ggacugcagc     1260

uggaccaaau cccugcuguc ucuuaacaug agcuccaaua uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccaua gcaacaagau caaaucuauu     1380

cccaagcagg ucgugaaacu ggaagcccuu caggagcuga auguugcuuu caacucccuc     1440

acggaucugc cuggaugcgg cagcuuuucu ucccugagcg ugcuuaucau ugaccacaac     1500

ucugucagcc aucccuccgc cgauuucuuc cagagcuguc agaagaugag aucuaucaaa     1560

gcgggggaca auccguuuca augcacaugu gagcucggag aguucgugaa gaacauugau     1620

caggucucca gcgaagugcu ggaaggcugg ccugacuccu auaagugcga cuaccccgag     1680

ucuuaucggg ggacccugcu caaagauuuu cacaugagcg aacuguccug caauaucacc     1740

cuucugaucg uuacaauugu ggccaccaug cucguccugg cugugacagu uacgucucug     1800

uguagcuacc uugaccuccc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaacauccc ccuggaggag cuccaacgga aucugcaguu ccacgcuuuu     1920

auuuccuacu cuggacauga uagcuucugg gucaagaacg aacuucugcc caaucucgag     1980

aaagaaggca ugcagaucug ucugcacgag cgcaacuuug ugccuggcaa guccauugug     2040

gagaauauca uuaccugcau ugaaaagagc uauaagucua ucuucguucu guccccgaac     2100

uuuguccaga gcgaguggug ucauuacgaa cuuuacuucg cccaccacaa ucuguuucau     2160

gaggggucua acucccucau ucugauccuc cuggaaccca uuccucaaua uagcaucccc     2220

ucuuccuacc acaaacuuaa aagccugaug gcgagacgga cauaucucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaucugcgcg cugccaucaa cauuaaacuu     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9564
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__Q5FWG5

<400>  9564

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Glu Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Asn Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Phe Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu Asn 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Val Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9565
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__AAH89403

<400>  9565
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugagggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uaacaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuucuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugaauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg gugaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9566
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__AAH89403

<400>  9566
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgaggggc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc uguccauccu cgccaagcug      720

cagaccaacc ccaagcugag cucccucacc cugaacaaca ucgagaccac guggaacagc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacuucuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccggcac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucgggu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccggcacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cucaaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcgggcac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu guccaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacagcguc agcuacgacg agaagaaggg cgacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccgggugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccuccgc cgacuucuuc cagagcugcc agaagaugcg gagcaucaag     1560

gcgggcgaca accccuucca gugcacgugc gagcuggggg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggagggcugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg ggacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg gugaagaacg agcugcuccc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag cggaacuucg ucccggggaa guccaucgug     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucguccagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gagggcagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

uccagcuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcgggcu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9567
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__AAH89403

<400>  9567
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccgagggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga caacaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuucuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cucaaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg gucaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9568
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__AAH89403

<400>  9568
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgaggggu uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggaaga caacaagugu aguuacuucc uaucuauucu ggcuaaacuc      720

cagacaaauc caaagcuguc cagccuuacc cugaacaaca ucgagacgac uuggaauagc      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuuuuc uaucuccaac      840

gucaaacugc agggacaguu agauuuccgu gacuuugauu acucaggcac uucacugaag      900

gcccuaagca uccaccaggu gguguccgac gucuucgguu uuccccaauc uuauauuuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccguuu cagggacaag aauggugcac     1020

augcucugcc cuaguaagau auccccauuc cugaaccuug acuuuagcaa uaacuugcug     1080

accgauacgg uauucgagaa uuguggacau cucacugagc uggaaacacu uauccugcag     1140

augaaccagu ugaaggagcu cucuaaaauu gcagaaauga ccacucaaau gaagucacug     1200

cagcaguuag acaucaguca gaauagcgug uccuacgaug agaaaaaggg cgacugcucu     1260

uggacaaaau cgcugcuaag ccucaacaug uccucaaaua uccugaccga uacgauuuuu     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaca guaacaagau caaaucuauu     1380

ccaaagcaag ugguuaaacu cgaagcccug caggaguuaa auguggcuuu caacagccug     1440

accgaucuuc cgggcugcgg guccuuuagu agcuugucug uccucaucau ugaccauaac     1500

uccgugaguc accccagcgc agauuucuuc cagucuuguc agaagaugcg cuccaucaaa     1560

gccggagaca auccuuuuca augcacaugu gagcugggug aguucguaaa gaacauagau     1620

cagguuucaa gugaagugcu agaaggcugg ccagacagcu auaagugcga cuaccccgag     1680

ucguauagag ggacucugcu caaagauuuu cauauguccg aacugucuug caauaucacc     1740

cuuuugauug ucacaaucgu ggcuacuaug cuggucuuag ccgugaccgu uacaagccuc     1800

uguauuuacc uggaccuucc uugguaucug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaacauccc auuggaggag cuccaaagga aucugcaguu ccacgcauuu     1920

auaucauaca guggacacga uuccuucugg guaaagaacg aacuacugcc caaucucgag     1980

aaagaaggca ugcagauuug ucugcaugag cggaacuuug ucccggguaa gucuaucgug     2040

gagaauauua ucacgugcau agaaaaaucg uauaagucca ucuucguucu uucaccuaac     2100

uuugugcaga gcgaguggug ucacuacgaa uuguacuucg cccaucacaa ucuguuucac     2160

gaggggagua acucuuuaau ucucauccug cuugaaccca uuccacaaua uuccaucccu     2220

agcucguacc auaagcugaa aucacuaaug gcucgucgca cauaucucga guggcccaag     2280

gagaaaucua agagaggacu guucugggcc aauuugaggg cagcuauaaa cauuaaacug     2340

accgaacagg ccaagaaaug a                                               2361


<210>  9569
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__AAH89403

<400>  9569
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccgagggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga caacaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacuucag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugaaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg gugaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9570
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__AAH89403

<400>  9570
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccugagggac ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggaaga caacaagugu agcuacuucc uuuccauccu ggccaaacuc      720

cagaccaauc cuaagcugag cucucuuaca cugaacaaca uugagaccac auggaacucc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauuuuag caucucuaau      840

gugaaacugc agggccagcu cgauuuccgc gacuuugauu acagcgggac aucccugaag      900

gcccuuucua uucaccaggu cguuagcgac guguucggau uuccccaauc cuauaucuac      960

gaaaucuuca gcaauaugaa cauuaaaaau uuuaccgugu cuggcacaag aaugguccac     1020

augcugugcc cuuccaagau cagcccguuc cucaaccugg acuuuucuaa uaaccugcuu     1080

accgauaccg uguucgagaa uuguggccau cucacagagc uggaaacgcu gauucuccag     1140

augaaccagc ugaaggagcu uuccaaaauc gcugaaauga ccacacaaau gaaaagccug     1200

cagcagcucg acauuuccca aaauucuguu agcuacgaug agaaaaaggg ggacugcucc     1260

uggaccaaau cucugcugag ccuuaacaug uccagcaaua uccucacaga uaccauuuuu     1320

cggugucugc ccccucgcau caaggugcug gaccuccacu cuaacaagau caaauccauu     1380

cccaagcagg ucgugaaacu ggaagcccuu caggagcuga auguugcuuu caacagccuc     1440

acggaucugc cuggaugcgg cucuuuuucc agccugucug ugcuuaucau ugaccauaac     1500

agcgucuccc accccagcgc cgauuucuuc cagucuuguc agaagaugag auccaucaaa     1560

gcgggggaca auccguuuca augcacaugu gagcucggag aguucgugaa gaacauugau     1620

caggucagcu ccgaagugcu ggaaggcugg ccugacucuu auaagugcga cuaccccgag     1680

agcuaucggg ggacccugcu caaagauuuu cauauguccg aacugucuug caauaucacc     1740

cuucugaucg uuacaauugu ggccaccaug cucguccugg cugugacagu uacgagccug     1800

uguaucuacc uugaccuccc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaacauucc ccuggaggag cuccaacgga aucugcaguu ccacgcuuuu     1920

aucuccuacu cuggacacga uagcuucugg gucaagaacg aacuucugcc caaucucgag     1980

aaagaaggca ugcagauuug ucugcaugag cgcaacuuug ugccuggcaa guccaucgug     2040

gagaauauca uuaccugcau cgaaaagagc uauaagucua uuuucguucu guccccgaac     2100

uuuguccaga gcgaguggug ucacuacgaa cuuuacuucg cccaucacaa ucuguuucac     2160

gaggggucua acucccucau ccugauucuc cuggaaccca ucccucaaua uagcaucccc     2220

ucuuccuacc auaaacuuaa gagccugaug gcgagacgga cauaucucga guggccuaag     2280

gagaaaucca agagaggacu guucugggcc aaucugcgcg cugccauuaa caucaaacuu     2340

accgaacagg cuaagaaaug a                                               2361


<210>  9571
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__Q6FI64

<400>  9571

Met Thr Ser Ile Phe His Phe Ala Ile Ile Phe Met Leu Ile Leu Gln 
1               5                   10                  15      


Ile Arg Ile Gln Leu Ser Glu Glu Ser Glu Phe Leu Val Asp Arg Ser 
            20                  25                  30          


Lys Asn Gly Leu Ile His Val Pro Lys Asp Leu Ser Gln Lys Thr Thr 
        35                  40                  45              


Ile Leu Asn Ile Ser Gln Asn Tyr Ile Ser Glu Leu Trp Thr Ser Asp 
    50                  55                  60                  


Ile Leu Ser Leu Ser Lys Leu Arg Ile Leu Ile Ile Ser His Asn Arg 
65                  70                  75                  80  


Ile Gln Tyr Leu Asp Ile Ser Val Phe Lys Phe Asn Gln Glu Leu Glu 
                85                  90                  95      


Tyr Leu Asp Leu Ser His Asn Lys Leu Val Lys Ile Ser Cys His Pro 
            100                 105                 110         


Thr Val Asn Leu Lys His Leu Asp Leu Ser Phe Asn Ala Phe Asp Ala 
        115                 120                 125             


Leu Pro Ile Cys Lys Glu Phe Gly Asn Met Ser Gln Leu Lys Phe Leu 
    130                 135                 140                 


Gly Leu Ser Thr Thr His Leu Glu Lys Ser Ser Val Leu Pro Ile Ala 
145                 150                 155                 160 


His Leu Asn Ile Ser Lys Val Leu Leu Val Leu Gly Glu Thr Tyr Gly 
                165                 170                 175     


Glu Lys Glu Asp Pro Gly Gly Leu Gln Asp Phe Asn Thr Glu Ser Leu 
            180                 185                 190         


His Ile Val Phe Pro Thr Asn Lys Glu Phe His Phe Ile Leu Asp Val 
        195                 200                 205             


Ser Val Lys Thr Val Ala Asn Leu Glu Leu Ser Asn Ile Lys Cys Val 
    210                 215                 220                 


Leu Glu Asp Ser Lys Cys Ser Tyr Phe Leu Ser Ile Leu Ala Lys Leu 
225                 230                 235                 240 


Gln Thr Asn Pro Lys Leu Ser Ser Leu Thr Leu Asn Asn Ile Glu Thr 
                245                 250                 255     


Thr Trp Asn Ser Phe Ile Arg Ile Leu Gln Leu Val Trp His Thr Thr 
            260                 265                 270         


Val Trp Tyr Ser Ser Ile Ser Asn Val Lys Leu Gln Gly Gln Leu Asp 
        275                 280                 285             


Phe Arg Asp Phe Asp Tyr Ser Gly Thr Ser Leu Lys Ala Leu Ser Ile 
    290                 295                 300                 


His Gln Val Val Ser Asp Val Phe Gly Phe Pro Gln Ser Tyr Ile Tyr 
305                 310                 315                 320 


Glu Ile Phe Ser Asn Met Asn Ile Lys Asn Phe Thr Val Ser Gly Thr 
                325                 330                 335     


Arg Met Val His Met Leu Cys Pro Ser Lys Ile Ser Pro Phe Leu His 
            340                 345                 350         


Leu Asp Phe Ser Asn Asn Leu Leu Thr Asp Thr Val Phe Glu Asn Cys 
        355                 360                 365             


Gly His Leu Thr Glu Leu Glu Thr Leu Ile Leu Gln Met Asn Gln Leu 
    370                 375                 380                 


Lys Glu Leu Ser Lys Ile Ala Glu Met Thr Thr Gln Met Lys Ser Leu 
385                 390                 395                 400 


Gln Gln Leu Asp Ile Ser Gln Asn Ser Val Ser Tyr Asp Glu Lys Lys 
                405                 410                 415     


Gly Asp Cys Ser Trp Thr Lys Ser Leu Leu Ser Leu Asn Met Ser Ser 
            420                 425                 430         


Asn Ile Leu Thr Asp Thr Ile Phe Arg Cys Leu Pro Pro Arg Ile Lys 
        435                 440                 445             


Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser Ile Pro Lys Gln Val 
    450                 455                 460                 


Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val Ala Phe Asn Ser Leu 
465                 470                 475                 480 


Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser Leu Ser Val Leu Ile 
                485                 490                 495     


Ile Asp His Asn Ser Val Ser His Pro Ser Ala Asp Phe Phe Gln Ser 
            500                 505                 510         


Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp Asn Pro Phe Gln Cys 
        515                 520                 525             


Thr Cys Glu Leu Gly Glu Phe Val Lys Asn Ile Asp Gln Val Ser Ser 
    530                 535                 540                 


Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys Cys Asp Tyr Pro Glu 
545                 550                 555                 560 


Ser Tyr Arg Gly Thr Leu Leu Lys Asp Phe His Met Ser Glu Leu Ser 
                565                 570                 575     


Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Val Ala Thr Met Leu Val 
            580                 585                 590         


Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr Leu Asp Leu Pro Trp 
        595                 600                 605             


Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr Arg Arg Arg Ala Arg 
    610                 615                 620                 


Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu Gln Phe His Ala Phe 
625                 630                 635                 640 


Ile Ser Tyr Ser Gly His Asp Ser Phe Trp Met Lys Asn Glu Leu Leu 
                645                 650                 655     


Pro Asn Leu Glu Lys Glu Gly Met Gln Ile Cys Leu His Glu Arg Asn 
            660                 665                 670         


Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile Ile Thr Cys Ile Glu 
        675                 680                 685             


Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Ser 
    690                 695                 700                 


Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His His Asn Leu Phe His 
705                 710                 715                 720 


Glu Gly Ser Asn Ser Leu Ile Leu Ile Leu Leu Glu Pro Ile Pro Gln 
                725                 730                 735     


Tyr Ser Ile Pro Ser Ser Tyr His Lys Leu Lys Ser Leu Met Ala Arg 
            740                 745                 750         


Arg Thr Tyr Leu Glu Trp Pro Lys Glu Lys Ser Lys Arg Gly Leu Phe 
        755                 760                 765             


Trp Ala Asn Leu Arg Ala Ala Ile Asn Ile Lys Leu Thr Glu Gln Ala 
    770                 775                 780                 


Lys Lys 
785     


<210>  9572
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR1__Homo_sapiens__CAG38593

<400>  9572
augacuagca ucuuccauuu ugccauuauc uucauguuaa uacuucagau cagaauacaa       60

uuaucugaag aaagugaauu uuuaguugau aggucaaaaa acggucucau ccacguuccu      120

aaagaccuau cccagaaaac aacaaucuua aauauaucgc aaaauuauau aucugagcuu      180

uggacuucug acaucuuauc acugucaaaa cugaggauuu ugauaauuuc ucauaauaga      240

auccaguauc uugauaucag uguuuucaaa uucaaccagg aauuggaaua cuuggauuug      300

ucccacaaca aguuggugaa gauuucuugc cacccuacug ugaaccucaa gcacuuggac      360

cugucauuua augcauuuga ugcccugccu auaugcaaag aguuuggcaa uaugucucaa      420

cuaaaauuuc ugggguugag caccacacac uuagaaaaau cuagugugcu gccaauugcu      480

cauuugaaua ucagcaaggu cuugcugguc uuaggagaga cuuaugggga aaaagaagac      540

ccugggggcc uucaagacuu uaacacugag agucugcaca uuguguuccc cacaaacaaa      600

gaauuccauu uuauuuugga ugugucaguc aagacuguag caaaucugga acuaucuaau      660

aucaaaugug ugcuagaaga uagcaaaugu ucuuacuucc uaaguauucu ggcgaaacuu      720

caaacaaauc caaaguuauc aagucuuacc uuaaacaaca uugaaacaac uuggaauucu      780

uucauuagga uccuccagcu gguuuggcau acaacuguau gguauuccuc aauuucaaac      840

gugaagcuac agggucagcu ggacuucaga gauuuugauu auucuggcac uuccuugaag      900

gccuugucua uacaccaagu ugucagcgau guguucgguu uuccgcaaag uuauaucuau      960

gaaaucuuuu cgaauaugaa caucaaaaau uucacagugu cugguacacg caugguccac     1020

augcuuugcc cauccaaaau uagcccguuc cugcauuugg auuuuuccaa uaaucucuua     1080

acagacacgg uuuuugaaaa uugugggcac cuuacugagu uggagacacu uauuuuacaa     1140

augaaucaau uaaaagaacu uucaaaaaua gcugaaauga cuacacagau gaagucucug     1200

caacaauugg auauuagcca gaauucugua agcuaugaug aaaagaaagg agacuguucu     1260

uggacuaaaa guuuauuaag uuuaaauaug ucuucaaaua uacuuacuga cacuauuuuc     1320

agauguuuac cucccaggau caagguacuu gaucuucaca gcaauaaaau aaagagcauu     1380

ccuaaacaag ucguaaaacu ggaagcuuug caagaacuca auguugcuuu caauucuuua     1440

acugaccuuc cuggaugugg cagcuuuagc agccuuucug uauugaucau ugaucacaau     1500

ucaguuuccc acccaucagc ugauuucuuc cagagcugcc agaagaugag gucaauaaaa     1560

gcaggggaca auccauucca auguaccugu gagcuaggag aauuugucaa aaauauagac     1620

caaguaucaa gugaaguguu agagggcugg ccugauucuu auaaguguga cuacccggaa     1680

aguuauagag gaacccuacu aaaggacuuu cacaugucug aauuauccug caacauaacu     1740

cugcugaucg ucaccaucgu ugccaccaug cugguguugg cugugacugu gaccucccuc     1800

ugcaucuacu uggaucugcc cugguaucuc aggauggugu gccaguggac ccagacccgg     1860

cgcagggcca ggaacauacc cuuagaagaa cuccaaagaa aucuccaguu ucaugcauuu     1920

auuucauaua gugggcacga uucuuucugg augaagaaug aauuauugcc aaaccuagag     1980

aaagaaggua ugcagauuug ccuucaugag agaaacuuug uuccuggcaa gagcauugug     2040

gaaaauauca ucaccugcau ugagaagagu uacaagucca ucuuuguuuu gucucccaac     2100

uuuguccaga gugaauggug ccauuaugaa cucuacuuug cccaucacaa ucucuuucau     2160

gaaggaucua auagcuuaau ccugaucuug cuggaaccca uuccgcagua cuccauuccu     2220

agcaguuauc acaagcucaa aagucucaug gccaggagga cuuauuugga auggcccaag     2280

gaaaagagca aacguggccu uuuuugggcu aacuuaaggg cagccauuaa uauuaagcug     2340

acagagcaag caaagaaaua g                                               2361


<210>  9573
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR1__Homo_sapiens__CAG38593

<400>  9573
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccuccagau ccgcauccag       60

cuguccgagg agagcgaguu ccugguggac cgguccaaga acggccucau ccacgucccc      120

aaggaccuga gccagaagac cacgauccug aacaucuccc agaacuacau cagcgagcuc      180

uggaccuccg acauccugag ccuguccaag cuccgcaucc ugaucaucag ccacaaccgg      240

auccaguacc uggacaucuc cguguucaag uucaaccagg agcucgagua ccuggaccug      300

agccacaaca agcucgugaa gaucuccugc cacccgaccg ucaaccugaa gcaccuggac      360

cucagcuuca acgccuucga cgcgcugccc aucugcaagg aguucgggaa caugucccag      420

cugaaguucc ucggccugag caccacgcac cuggagaagu ccagcgugcu ccccaucgcc      480

caccugaaca ucuccaaggu gcugcucguc cugggggaga ccuacggcga gaaggaggac      540

cccgggggcc ugcaggacuu caacaccgag agccuccaca ucguguuccc gaccaacaag      600

gaguuccacu ucauccugga cgugagcguc aagacggugg ccaaccugga gcucuccaac      660

aucaagugcg ugcuggagga cagcaagugc uccuacuucc ugagcauccu cgccaagcug      720

cagaccaacc ccaagcuguc cagccucacc cugaacaaca ucgagaccac guggaacucc      780

uucauccgca uccugcagcu cgucuggcac accaccgugu gguacagcuc caucagcaac      840

gugaagcugc agggccagcu ggacuuccgg gacuucgacu acuccgggac cagccucaag      900

gcccugucca uccaccaggu cgugagcgac guguucggcu ucccccaguc cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucacggucu ccgggacccg cauggugcac     1020

augcugugcc ccagcaagau cuccccguuc cuccaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cucacggagc uggagacccu gauccuccag     1140

augaaccagc ugaaggagcu gagcaagauc gcggagauga ccacccagau gaagucccuc     1200

cagcagcugg acaucagcca gaacuccguc agcuacgacg agaagaaggg ggacugcucc     1260

uggaccaaga gccugcucuc ccugaacaug agcuccaaca uccugaccga caccaucuuc     1320

cggugccucc cgccccgcau caaggugcug gaccugcaca gcaacaagau caaguccauc     1380

cccaagcagg ucgugaagcu cgaggcccug caggagcuga acguggccuu caacagccuc     1440

accgaccugc ccggcugcgg cuccuucagc ucccugagcg uccucaucau cgaccacaac     1500

uccgugagcc accccagcgc cgacuucuuc caguccugcc agaagaugcg gagcaucaag     1560

gcgggggaca accccuucca gugcacgugc gagcugggcg aguucgugaa gaacaucgac     1620

caggucucca gcgaggugcu ggaggggugg cccgacuccu acaagugcga cuacccggag     1680

agcuaccgcg gcacccuccu gaaggacuuc cacauguccg agcugagcug caacaucacc     1740

cuccugaucg ugaccaucgu cgccacgaug cuggugcucg ccgugaccgu caccucccug     1800

ugcaucuacc uggaccuccc cugguaccug cggauggugu gccaguggac ccagacgcgc     1860

cggcgcgccc ggaacauccc ccuggaggag cuccagcgca accugcaguu ccacgccuuc     1920

aucagcuacu ccggccacga cagcuucugg augaagaacg agcugcuccc caaccuggag     1980

aaggagggga ugcagaucug ccugcacgag cggaacuucg ugccgggcaa guccaucguc     2040

gagaacauca ucacgugcau cgagaagucc uacaagagca ucuucgugcu cagccccaac     2100

uucgugcagu ccgaguggug ccacuacgag cuguacuucg cgcaccacaa ccuguuccac     2160

gaggggagca acucccucau ccugauccug cucgagccca ucccccagua cagcaucccg     2220

agcuccuacc acaagcucaa gagccugaug gcccgccgga ccuaccugga guggcccaag     2280

gagaagucca agcgcggccu guucugggcc aaccugcggg ccgccaucaa caucaagcuc     2340

accgagcagg cgaagaagug a                                               2361


<210>  9574
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR1__Homo_sapiens__CAG38593

<400>  9574
augaccucca ucuuccacuu cgccaucauc uucaugcuca uccuccagau ccgcauccag       60

cucuccgagg aguccgaguu ccucgucgac cgcuccaaga acggccucau ccacgucccc      120

aaggaccucu cccagaagac caccauccuc aacaucuccc agaacuacau cuccgagcuc      180

uggaccuccg acauccucuc ccucuccaag cuccgcaucc ucaucaucuc ccacaaccgc      240

auccaguacc ucgacaucuc cgucuucaag uucaaccagg agcucgagua ccucgaccuc      300

ucccacaaca agcucgucaa gaucuccugc caccccaccg ucaaccucaa gcaccucgac      360

cucuccuuca acgccuucga cgcccucccc aucugcaagg aguucggcaa caugucccag      420

cucaaguucc ucggccucuc caccacccac cucgagaagu ccuccguccu ccccaucgcc      480

caccucaaca ucuccaaggu ccuccucguc cucggcgaga ccuacggcga gaaggaggac      540

cccggcggcc uccaggacuu caacaccgag ucccuccaca ucgucuuccc caccaacaag      600

gaguuccacu ucauccucga cgucuccguc aagaccgucg ccaaccucga gcucuccaac      660

aucaagugcg uccucgagga cuccaagugc uccuacuucc ucuccauccu cgccaagcuc      720

cagaccaacc ccaagcucuc cucccucacc cucaacaaca ucgagaccac cuggaacucc      780

uucauccgca uccuccagcu cgucuggcac accaccgucu gguacuccuc caucuccaac      840

gucaagcucc agggccagcu cgacuuccgc gacuucgacu acuccggcac cucccucaag      900

gcccucucca uccaccaggu cgucuccgac gucuucggcu ucccccaguc cuacaucuac      960

gagaucuucu ccaacaugaa caucaagaac uucaccgucu ccggcacccg caugguccac     1020

augcucugcc ccuccaagau cucccccuuc cuccaccucg acuucuccaa caaccuccuc     1080

accgacaccg ucuucgagaa cugcggccac cucaccgagc ucgagacccu cauccuccag     1140

augaaccagc ucaaggagcu cuccaagauc gccgagauga ccacccagau gaagucccuc     1200

cagcagcucg acaucuccca gaacuccguc uccuacgacg agaagaaggg cgacugcucc     1260

uggaccaagu cccuccucuc ccucaacaug uccuccaaca uccucaccga caccaucuuc     1320

cgcugccucc ccccccgcau caagguccuc gaccuccacu ccaacaagau caaguccauc     1380

cccaagcagg ucgucaagcu cgaggcccuc caggagcuca acgucgccuu caacucccuc     1440

accgaccucc ccggcugcgg cuccuucucc ucccucuccg uccucaucau cgaccacaac     1500

uccgucuccc accccuccgc cgacuucuuc caguccugcc agaagaugcg cuccaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcucggcg aguucgucaa gaacaucgac     1620

caggucuccu ccgagguccu cgagggcugg cccgacuccu acaagugcga cuaccccgag     1680

uccuaccgcg gcacccuccu caaggacuuc cacauguccg agcucuccug caacaucacc     1740

cuccucaucg ucaccaucgu cgccaccaug cucguccucg ccgucaccgu caccucccuc     1800

ugcaucuacc ucgaccuccc cugguaccuc cgcauggucu gccaguggac ccagacccgc     1860

cgccgcgccc gcaacauccc ccucgaggag cuccagcgca accuccaguu ccacgccuuc     1920

aucuccuacu ccggccacga cuccuucugg augaagaacg agcuccuccc caaccucgag     1980

aaggagggca ugcagaucug ccuccacgag cgcaacuucg uccccggcaa guccaucguc     2040

gagaacauca ucaccugcau cgagaagucc uacaagucca ucuucguccu cucccccaac     2100

uucguccagu ccgaguggug ccacuacgag cucuacuucg cccaccacaa ccucuuccac     2160

gagggcucca acucccucau ccucauccuc cucgagccca ucccccagua cuccaucccc     2220

uccuccuacc acaagcucaa gucccucaug gcccgccgca ccuaccucga guggcccaag     2280

gagaagucca agcgcggccu cuucugggcc aaccuccgcg ccgccaucaa caucaagcuc     2340

accgagcagg ccaagaagug a                                               2361


<210>  9575
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR1__Homo_sapiens__CAG38593

<400>  9575
augaccagca ucuuccacuu ugccauuaua uucaugcuga uccuccagau uagaauccaa       60

cuuuccgagg aaucugaguu ucugguggac aggucaaaga acggcuugau ucaugucccc      120

aaagauuuaa gucagaagac aacuauccug aauauaagcc agaacuacau cuccgaacua      180

uggacgucug acauucucuc gcugucaaaa cuucggaucc ugauuaucag ccacaaucgc      240

auacaguauu uggauauuag uguuuucaag uuuaaccaag agcucgaaua ccuggaccug      300

ucccauaaua aacucgugaa gaucucuugc cacccuaccg uaaacuuaaa gcaucuggau      360

cuuagcuuca augcuuuuga cgcauugcca auuuguaaag aguucgggaa caugucccag      420

cugaaguuuc uaggacucuc aacaacucac cuggagaaaa guagcgugcu uccgaucgcc      480

caccugaaua ucucuaaggu cuugcucgug cugggugaaa ccuauggcga gaaagaagau      540

cccgggggau uacaggacuu caacacagag ucccugcaua uuguuuuucc uaccaauaag      600

gaguuccacu uuauacucga ugugucaguc aagacugugg cgaaccuuga acugagcaau      660

aucaaaugcg uauuggagga caguaagugu ucuuacuucc uauccauucu ggcuaaacuc      720

cagacaaacc caaagcugag cucgcuuacc cugaauaaca ucgaaacgac uuggaacucu      780

uucauacgaa uuuugcaacu cguuuggcau accacagugu gguauuccuc aaucaguaau      840

gucaaacugc agggccaguu agauuuucgu gacuucgauu acagcgguac uucccugaag      900

gcccuaucua uccaccaggu ggugagcgac gucuuugggu ucccccaauc auauauuuac      960

gagaucuuua guaacaugaa uauuaaaaac uucaccguuu ccggaacaag aauggugcac     1020

augcucugcc cuagcaagau aucuccauuu cugcaucuug acuucucaaa uaacuugcug     1080

accgauacgg uauuugaaaa uuguggccac cucacugagc uggagacacu uauccugcag     1140

augaaccagu ugaaggaacu caguaaaauu gcagagauga ccacucaaau gaaaagccug     1200

cagcaguuag acaucuccca gaauagcgug ucguacgaug aaaagaaggg cgacugcagc     1260

uggacaaaau cccugcuauc acucaacaug aguucuaaua uccugaccga uacgauuuuc     1320

aggugucuuc ccccucggau aaaggucuug gaccugcaua gcaacaagau caaauccauu     1380

ccaaagcaag ugguuaaacu cgaggcccug caggaauuaa auguggcuuu uaacucacug     1440

accgaucuuc cggggugcgg aucuuucucu uccuugagug uccucaucau ugaccacaau     1500

agcgugucuc aucccuccgc agacuuuuuc cagucauguc agaagaugcg caguaucaaa     1560

gccggugaua acccuuucca augcacaugu gagcugggcg aguuuguaaa gaacauagau     1620

cagguuagcu cggaagugcu agaggggugg ccagacuccu auaagugcga cuaccccgaa     1680

ucuuauagag gaacucugcu caaagauuuc cacaugagcg agcugucaug caauaucacc     1740

cuuuugauug ucacaaucgu ggcuacuaug cuggucuuag ccgugaccgu uacaagucuc     1800

uguauuuacc uggaccuucc uugguaucug aggauggugu gccaguggac ccagacucgg     1860

cgccgagcga gaaacauccc auuggaggaa cuccaaagga aucugcaguu ucacgcauuc     1920

auauccuacu cuggccauga uagcuuuugg augaagaacg agcuacugcc caaucucgaa     1980

aaagagggua ugcagauuug ucugcacgaa cggaacuucg uaccggggaa guccaucguc     2040

gagaauauua ucacgugcau agagaaauca uauaagagca ucuuugugcu uaguccuaac     2100

uucguucagu cugaauggug ucauuacgag uuguacuuug cccaccacaa ucuguuccau     2160

gaaggaucca acagcuuaau ucucauccug cuugagccca uuccacaaua uucgaucccu     2220

ucaucuuacc acaagcugaa aagucuaaug gcucgucgca cauaucucga auggcccaag     2280

gagaaaucca agagaggccu guuuugggcc aauuugaggg cagcuauaaa cauuaaacug     2340

accgagcagg ccaagaaaug a                                               2361


<210>  9576
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR1__Homo_sapiens__CAG38593

<400>  9576
augaccagca ucuuccacuu cgccaucauc uucaugcuga uccugcagau cagaauccag       60

cugagcgagg agagcgaguu ccugguggac agaagcaaga acggccugau ccacgugccc      120

aaggaccuga gccagaagac caccauccug aacaucagcc agaacuacau cagcgagcug      180

uggaccagcg acauccugag ccugagcaag cugagaaucc ugaucaucag ccacaacaga      240

auccaguacc uggacaucag cguguucaag uucaaccagg agcuggagua ccuggaccug      300

agccacaaca agcuggugaa gaucagcugc caccccaccg ugaaccugaa gcaccuggac      360

cugagcuuca acgccuucga cgcccugccc aucugcaagg aguucggcaa caugagccag      420

cugaaguucc ugggccugag caccacccac cuggagaaga gcagcgugcu gcccaucgcc      480

caccugaaca ucagcaaggu gcugcuggug cugggcgaga ccuacggcga gaaggaggac      540

cccggcggcc ugcaggacuu caacaccgag agccugcaca ucguguuccc caccaacaag      600

gaguuccacu ucauccugga cgugagcgug aagaccgugg ccaaccugga gcugagcaac      660

aucaagugcg ugcuggagga cagcaagugc agcuacuucc ugagcauccu ggccaagcug      720

cagaccaacc ccaagcugag cagccugacc cugaacaaca ucgagaccac cuggaacagc      780

uucaucagaa uccugcagcu gguguggcac accaccgugu gguacagcag caucagcaac      840

gugaagcugc agggccagcu ggacuucaga gacuucgacu acagcggcac cagccugaag      900

gcccugagca uccaccaggu ggugagcgac guguucggcu ucccccagag cuacaucuac      960

gagaucuuca gcaacaugaa caucaagaac uucaccguga gcggcaccag aauggugcac     1020

augcugugcc ccagcaagau cagccccuuc cugcaccugg acuucagcaa caaccugcug     1080

accgacaccg uguucgagaa cugcggccac cugaccgagc uggagacccu gauccugcag     1140

augaaccagc ugaaggagcu gagcaagauc gccgagauga ccacccagau gaagagccug     1200

cagcagcugg acaucagcca gaacagcgug agcuacgacg agaagaaggg cgacugcagc     1260

uggaccaaga gccugcugag ccugaacaug agcagcaaca uccugaccga caccaucuuc     1320

agaugccugc cccccagaau caaggugcug gaccugcaca gcaacaagau caagagcauc     1380

cccaagcagg uggugaagcu ggaggcccug caggagcuga acguggccuu caacagccug     1440

accgaccugc ccggcugcgg cagcuucagc agccugagcg ugcugaucau cgaccacaac     1500

agcgugagcc accccagcgc cgacuucuuc cagagcugcc agaagaugag aagcaucaag     1560

gccggcgaca accccuucca gugcaccugc gagcugggcg aguucgugaa gaacaucgac     1620

caggugagca gcgaggugcu ggagggcugg cccgacagcu acaagugcga cuaccccgag     1680

agcuacagag gcacccugcu gaaggacuuc cacaugagcg agcugagcug caacaucacc     1740

cugcugaucg ugaccaucgu ggccaccaug cuggugcugg ccgugaccgu gaccagccug     1800

ugcaucuacc uggaccugcc cugguaccug agaauggugu gccaguggac ccagaccaga     1860

agaagagcca gaaacauccc ccuggaggag cugcagagaa accugcaguu ccacgccuuc     1920

aucagcuaca gcggccacga cagcuucugg augaagaacg agcugcugcc caaccuggag     1980

aaggagggca ugcagaucug ccugcacgag agaaacuucg ugcccggcaa gagcaucgug     2040

gagaacauca ucaccugcau cgagaagagc uacaagagca ucuucgugcu gagccccaac     2100

uucgugcaga gcgaguggug ccacuacgag cuguacuucg cccaccacaa ccuguuccac     2160

gagggcagca acagccugau ccugauccug cuggagccca ucccccagua cagcaucccc     2220

agcagcuacc acaagcugaa gagccugaug gccagaagaa ccuaccugga guggcccaag     2280

gagaagagca agagaggccu guucugggcc aaccugagag ccgccaucaa caucaagcug     2340

accgagcagg ccaagaagug a                                               2361


<210>  9577
<211>  2361
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR1__Homo_sapiens__CAG38593

<400>  9577
augaccagca ucuuccacuu ugccauuauc uucaugcuga uucuccagau ccggauucaa       60

cuguccgagg aaucugaguu ucuuguggac agaagcaaga acggccugau ccaugucccc      120

aaagaucucu cccagaagac aacgauccug aauauuucuc agaacuacau cagcgaacuu      180

uggaccuccg acauucuguc ucucagcaaa cugcgcaucc ugauuaucuc ccacaauaga      240

auccaguauc ucgauauuag cguuuucaag uuuaaccaag agcuggaaua ccuugaccug      300

ucucauaaua aacucgugaa gaucuccugc cacccuacag ugaaccugaa gcaucuugau      360

cugagcuuca augcuuuuga cgcccucccg auuuguaaag aguucgggaa caugucucag      420

cugaaguuuc ugggacucuc caccacacac cuggagaaaa gcucuguccu ucccaucgcg      480

caccugaaua uuuccaaggu gcuccugguu cuuggcgaaa ccuaugggga gaaagaagau      540

ccuggaggcc ugcaggacuu caacacagag agccuccaua ucguguuucc caccaauaag      600

gaguuccacu uuauucugga ugucuccgug aagacgguug cuaaccugga acucucuaau      660

aucaaaugcg ugcuggagga cagcaagugu uccuacuucc uuagcauccu ggccaaacuc      720

cagaccaacc cuaagcuguc uucccuuaca cugaauaaca uugaaaccac auggaacagc      780

uucauccgga uucuccaacu ggucuggcau accacggugu gguauucuag caucuccaau      840

gugaaacugc aggggcagcu cgauuuucgc gacuucgauu acucuggaac aagccugaag      900

gcccuuucca uucaccaggu cguuagcgac guguuuggcu ucccccaauc uuauaucuac      960

gagaucuuuu ccaacaugaa uauuaaaaac uucaccguga gcggcacaag aaugguccac     1020

augcugugcc cuucuaagau cuccccguuu cuccaucugg acuucagcaa uaaccugcuu     1080

accgauaccg uguuugaaaa uugugggcac cucacagagc uggagacgcu gauucuccag     1140

augaaccagc ugaaggaacu uuccaaaauc gcugagauga ccacacaaau gaagucucug     1200

cagcagcucg acauuagcca aaauuccguu ucuuacgaug aaaagaaggg agacugcagc     1260

uggaccaaau cccugcugag ccuuaacaug ucuuccaaua uccucacaga uaccauuuuc     1320

cggugucugc ccccucgcau caaggugcug gaccuccaua gcaacaagau caaaucuauu     1380

cccaagcagg ucgugaaacu ggaggcccuu caggaacuga auguugcuuu uaacucccuc     1440

acggaucugc cuggcugcgg gagcuucucu agccuguccg ugcuuaucau ugaccacaau     1500

agcgucucuc aucccuccgc cgacuuuuuc cagagcuguc agaagaugag auccaucaaa     1560

gcgggagaua acccguucca augcacaugu gagcucggcg aguuugugaa gaacauugau     1620

caggucucua gcgaagugcu ggaggggugg ccugacuccu auaagugcga cuaccccgaa     1680

ucuuaucggg gaacccugcu caaagauuuc cacaugagcg agcuguccug caauaucacc     1740

cuucugaucg uuacaauugu ggccaccaug cucguccugg cugugacagu uacgucucug     1800

uguaucuacc uugaccuccc uugguaucug cgcauggugu gccaguggac ccagacaaga     1860

cggcgcgcca gaaacauucc ccuggaggaa cuccaacgga aucugcaguu ucacgcuuuc     1920

aucagcuacu ccggccauga uagcuuuugg augaagaacg agcuucugcc caaucucgaa     1980

aaagagggca ugcagauuug ucugcacgaa cgcaacuucg ucccugggaa gucuaucgug     2040

gagaauauca uuaccugcau cgagaaaucc uauaagagca uuuuugugcu gucuccgaac     2100

uucguucagu ccgaauggug ucauuacgag cuuuacuuug cccaccacaa ucuguuccau     2160

gaaggaagca acucucucau ccugauucuc cuggagccca ucccucaaua uuccaucccc     2220

agcuccuacc acaaacuuaa aagccugaug gcgagacgga cauaucucga auggccuaag     2280

gagaaaucua agagaggccu guuuugggcc aaucugcgcg cugccauuaa caucaaacuu     2340

accgagcagg cuaagaaaug a                                               2361


<210>  9578
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR2__Homo_sapiens__O60603

<400>  9578

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 






<210>  9579
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR2__Homo_sapiens__AAC34377

<400>  9579
augccacaua cuuuguggau gguguggguc cuggggguca ucaucagccu cuccaaggaa       60

gaauccucca aucaggcuuc ucugucuugu gaccgcaaug guaucugcaa gggcagcuca      120

ggaucuuuaa acuccauucc cucagggcuc acagaagcug uaaaaagccu ugaccugucc      180

aacaacagga ucaccuacau uagcaacagu gaccuacaga ggugugugaa ccuccaggcu      240

cuggugcuga cauccaaugg aauuaacaca auagaggaag auucuuuuuc uucccugggc      300

agucuugaac auuuagacuu auccuauaau uacuuaucua auuuaucguc uuccugguuc      360

aagccccuuu cuucuuuaac auucuuaaac uuacugggaa auccuuacaa aacccuaggg      420

gaaacaucuc uuuuuucuca ucucacaaaa uugcaaaucc ugagaguggg aaauauggac      480

accuucacua agauucaaag aaaagauuuu gcuggacuua ccuuccuuga ggaacuugag      540

auugaugcuu cagaucuaca gagcuaugag ccaaaaaguu ugaagucaau ucagaaugua      600

agucaucuga uccuucauau gaagcagcau auuuuacugc uggagauuuu uguagauguu      660

acaaguuccg uggaauguuu ggaacugcga gauacugauu uggacacuuu ccauuuuuca      720

gaacuaucca cuggugaaac aaauucauug auuaaaaagu uuacauuuag aaaugugaaa      780

aucaccgaug aaaguuuguu ucagguuaug aaacuuuuga aucagauuuc uggauuguua      840

gaauuagagu uugaugacug uacccuuaau ggaguuggua auuuuagagc aucugauaau      900

gacagaguua uagauccagg uaaaguggaa acguuaacaa uccggaggcu gcauauucca      960

agguuuuacu uauuuuauga ucugagcacu uuauauucac uuacagaaag aguuaaaaga     1020

aucacaguag aaaacaguaa aguuuuucug guuccuuguu uacuuucaca acauuuaaaa     1080

ucauuagaau acuuggaucu cagugaaaau uugaugguug aagaauacuu gaaaaauuca     1140

gccugugagg augccuggcc cucucuacaa acuuuaauuu uaaggcaaaa ucauuuggca     1200

ucauuggaaa aaaccggaga gacuuugcuc acucugaaaa acuugacuaa cauugauauc     1260

aguaagaaua guuuucauuc uaugccugaa acuugucagu ggccagaaaa gaugaaauau     1320

uugaacuuau ccagcacacg aauacacagu guaacaggcu gcauucccaa gacacuggaa     1380

auuuuagaug uuagcaacaa caaucucaau uuauuuucuu ugaauuugcc gcaacucaaa     1440

gaacuuuaua uuuccagaaa uaaguugaug acucuaccag augccucccu cuuacccaug     1500

uuacuaguau ugaaaaucag uaggaaugca auaacuacgu uuucuaagga gcaacuugac     1560

ucauuucaca cacugaagac uuuggaagcu gguggcaaua acuucauuug cuccugugaa     1620

uuccucuccu ucacucagga gcagcaagca cuggccaaag ucuugauuga uuggccagca     1680

aauuaccugu gugacucucc aucccaugug cguggccagc agguucagga uguccgccuc     1740

ucggugucgg aaugucacag gacagcacug gugucuggca ugugcugugc ucuguuccug     1800

cugauccugc ucacgggggu ccugugccac cguuuccaug gccuguggua uaugaaaaug     1860

augugggccu ggcuccaggc caaaaggaag cccaggaaag cucccagcag gaacaucugc     1920

uaugaugcau uuguuucuua cagugagcgg gaugccuacu ggguggagaa ccuuaugguc     1980

caggagcugg agaacuucaa uccccccuuc aaguuguguc uucauaagcg ggacuucauu     2040

ccuggcaagu ggaucauuga caauaucauu gacuccauug aaaagagcca caaaacuguc     2100

uuugugcuuu cugaaaacuu ugugaagagu gaguggugca aguaugaacu ggacuucucc     2160

cauuuccguc uuuuugauga gaacaaugau gcugccauuc ucauucuucu ggagcccauu     2220

gagaaaaaag ccauucccca gcgcuucugc aagcugcgga agauaaugaa caccaagacc     2280

uaccuggagu ggcccaugga cgaggcucag cgggaaggau uuuggguaaa ucugagagcu     2340

gcgauaaagu ccuag                                                      2355


<210>  9580
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR2__Homo_sapiens__AAC34377

<400>  9580
augccccaca cccuguggau gguguggguc cucggcguga ucaucagccu guccaaggag       60

gagagcucca accaggccag ccuguccugc gaccgcaacg ggaucugcaa gggcagcucc      120

gggagccuca acuccauccc gagcggccug accgaggccg ugaagucccu ggaccucagc      180

aacaaccgga ucacguacau cuccaacagc gaccugcagc gcugcgucaa ccugcaggcg      240

cucgugcuga ccuccaacgg gaucaacacc aucgaggagg acagcuucuc cagccugggc      300

ucccucgagc accuggaccu gagcuacaac uaccucagca accuguccag cuccugguuc      360

aagccccuga gcucccucac cuuccugaac cugcucggca accccuacaa gacgcugggg      420

gagaccagcc uguucuccca ccucaccaag cugcagaucc ugcggguggg caacauggac      480

accuucacga agauccagcg caaggacuuc gccgggcuca ccuuccugga ggagcuggag      540

aucgacgcca gcgaccucca guccuacgag cccaagagcc ugaaguccau ccagaacguc      600

agccaccuga uccuccacau gaagcagcac auccugcugc ucgagaucuu cguggacgug      660

accuccagcg ucgagugccu ggagcugcgg gacaccgacc ucgacacguu ccacuucucc      720

gagcugagca ccggcgagac caacucccug aucaagaagu ucaccuuccg caacgugaag      780

aucacggacg agagccucuu ccaggugaug aagcugcuga accagaucuc cgggcuccug      840

gagcuggagu ucgacgacug cacccucaac ggcgucggca acuuccgggc cagcgacaac      900

gaccgcguga ucgacccggg gaagguggag acccugacca uccggcgccu gcacaucccc      960

cgguucuacc uguucuacga ccucagcacg cuguacuccc ugaccgagcg cgucaagcgg     1020

aucaccgugg agaacagcaa gguguuccuc guccccugcc ugcuguccca gcaccucaag     1080

agccuggagu accuggaccu cuccgagaac cugauggugg aggaguaccu gaagaacagc     1140

gccugcgagg acgcguggcc cucccuccag acccugaucc ugcgccagaa ccaccucgcc     1200

agccuggaga agacgggcga gacccugcuc acccugaaga accugaccaa caucgacauc     1260

uccaagaaca gcuuccacuc caugccggag acgugccagu ggcccgagaa gaugaaguac     1320

cucaaccuga gcuccacccg gauccacagc gugaccgggu gcauccccaa gacccuggag     1380

auccucgacg ucuccaacaa caaccugaac cuguucagcc ucaaccugcc ccagcugaag     1440

gagcucuaca ucucccgcaa caagcugaug acgcugccgg acgccagccu ccugcccaug     1500

cugcucgugc ugaagaucag ccggaacgcc aucaccaccu ucuccaagga gcagcuggac     1560

agcuuccaca cccucaagac gcuggaggcg ggcggcaaca acuucaucug cuccugcgag     1620

uuccugagcu ucacccagga gcagcaggcc cucgccaagg ugcugaucga cuggcccgcc     1680

aacuaccugu gcgacucccc cagccacguc cgcgggcagc agguccagga cgugcggcuc     1740

uccgugagcg agugccaccg caccgcccug guguccggca ugugcugcgc gcuguuccuc     1800

cugauccugc ucaccggggu ccugugccac cgguuccacg gccuguggua caugaagaug     1860

augugggccu ggcuccaggc caagcgcaag ccgcgcaagg cccccagccg gaacaucugc     1920

uacgacgccu ucguguccua cagcgagcgc gacgcguacu ggguggagaa ccugaugguc     1980

caggagcugg agaacuucaa cccgcccuuc aagcucugcc ugcacaagcg ggacuucauc     2040

cccgggaagu ggaucaucga caacaucauc gacuccaucg agaaguccca caagaccgug     2100

uucgugcuga gcgagaacuu cgucaagagc gaguggugca aguacgagcu cgacuucucc     2160

cacuuccgcc uguucgacga gaacaacgac gccgccaucc ugauccuccu ggagcccauc     2220

gagaagaagg ccauccccca gcgguucugc aagcugcgca agaucaugaa cacgaagacc     2280

uaccucgagu ggcccaugga cgaggcccag cgggagggcu ucugggugaa ccugcgcgcg     2340

gccaucaaga gcuga                                                      2355


<210>  9581
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR2__Homo_sapiens__AAC34377

<400>  9581
augccccaca cccucuggau ggucuggguc cucggcguca ucaucucccu cuccaaggag       60

gaguccucca accaggccuc ccucuccugc gaccgcaacg gcaucugcaa gggcuccucc      120

ggcucccuca acuccauccc cuccggccuc accgaggccg ucaagucccu cgaccucucc      180

aacaaccgca ucaccuacau cuccaacucc gaccuccagc gcugcgucaa ccuccaggcc      240

cucguccuca ccuccaacgg caucaacacc aucgaggagg acuccuucuc cucccucggc      300

ucccucgagc accucgaccu cuccuacaac uaccucucca accucuccuc cuccugguuc      360

aagccccucu ccucccucac cuuccucaac cuccucggca accccuacaa gacccucggc      420

gagaccuccc ucuucuccca ccucaccaag cuccagaucc uccgcgucgg caacauggac      480

accuucacca agauccagcg caaggacuuc gccggccuca ccuuccucga ggagcucgag      540

aucgacgccu ccgaccucca guccuacgag cccaaguccc ucaaguccau ccagaacguc      600

ucccaccuca uccuccacau gaagcagcac auccuccucc ucgagaucuu cgucgacguc      660

accuccuccg ucgagugccu cgagcuccgc gacaccgacc ucgacaccuu ccacuucucc      720

gagcucucca ccggcgagac caacucccuc aucaagaagu ucaccuuccg caacgucaag      780

aucaccgacg agucccucuu ccaggucaug aagcuccuca accagaucuc cggccuccuc      840

gagcucgagu ucgacgacug cacccucaac ggcgucggca acuuccgcgc cuccgacaac      900

gaccgcguca ucgaccccgg caaggucgag acccucacca uccgccgccu ccacaucccc      960

cgcuucuacc ucuucuacga ccucuccacc cucuacuccc ucaccgagcg cgucaagcgc     1020

aucaccgucg agaacuccaa ggucuuccuc guccccugcc uccucuccca gcaccucaag     1080

ucccucgagu accucgaccu cuccgagaac cucauggucg aggaguaccu caagaacucc     1140

gccugcgagg acgccuggcc cucccuccag acccucaucc uccgccagaa ccaccucgcc     1200

ucccucgaga agaccggcga gacccuccuc acccucaaga accucaccaa caucgacauc     1260

uccaagaacu ccuuccacuc caugcccgag accugccagu ggcccgagaa gaugaaguac     1320

cucaaccucu ccuccacccg cauccacucc gucaccggcu gcauccccaa gacccucgag     1380

auccucgacg ucuccaacaa caaccucaac cucuucuccc ucaaccuccc ccagcucaag     1440

gagcucuaca ucucccgcaa caagcucaug acccuccccg acgccucccu ccuccccaug     1500

cuccucgucc ucaagaucuc ccgcaacgcc aucaccaccu ucuccaagga gcagcucgac     1560

uccuuccaca cccucaagac ccucgaggcc ggcggcaaca acuucaucug cuccugcgag     1620

uuccucuccu ucacccagga gcagcaggcc cucgccaagg uccucaucga cuggcccgcc     1680

aacuaccucu gcgacucccc cucccacguc cgcggccagc agguccagga cguccgccuc     1740

uccgucuccg agugccaccg caccgcccuc gucuccggca ugugcugcgc ccucuuccuc     1800

cucauccucc ucaccggcgu ccucugccac cgcuuccacg gccucuggua caugaagaug     1860

augugggccu ggcuccaggc caagcgcaag ccccgcaagg cccccucccg caacaucugc     1920

uacgacgccu ucgucuccua cuccgagcgc gacgccuacu gggucgagaa ccucaugguc     1980

caggagcucg agaacuucaa cccccccuuc aagcucugcc uccacaagcg cgacuucauc     2040

cccggcaagu ggaucaucga caacaucauc gacuccaucg agaaguccca caagaccguc     2100

uucguccucu ccgagaacuu cgucaagucc gaguggugca aguacgagcu cgacuucucc     2160

cacuuccgcc ucuucgacga gaacaacgac gccgccaucc ucauccuccu cgagcccauc     2220

gagaagaagg ccauccccca gcgcuucugc aagcuccgca agaucaugaa caccaagacc     2280

uaccucgagu ggcccaugga cgaggcccag cgcgagggcu ucugggucaa ccuccgcgcc     2340

gccaucaagu ccuga                                                      2355


<210>  9582
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR2__Homo_sapiens__AAC34377

<400>  9582
augccccaca cccuguggau gguguggguc cucggcguua ucauuagccu uuccaaggag       60

gaaucuucaa accaggccag ucugagcugc gacagaaaug ggauauguaa aggauccucu      120

gguucguuga acucaauccc uagcggcuua acagaggcug ugaagagucu ggaucuaucc      180

aauaacagga uuacuuacau cucuaauagc gaccuccaac ggugcguaaa ccugcaggca      240

cuugugcuga cguccaaugg gauuaacacc aucgaagagg auucauucag uagcuuggga      300

ucucucgaac aucuggaccu guccuauaau uaccucucaa acuuaagcag uucuugguuu      360

aaaccacugu ccagccuuac auucuugaau cugcuaggca acccguauaa gacucucggu      420

gagaccucgc uguuuucuca ccuuacaaaa cugcagauau ugcgcgucgg gaauauggau      480

accuucacua agauccagcg aaaggacuuu gccggacuca cauuccugga ggaauuagag      540

auugaugcgu ccgaccugca aucauacgaa cccaaaaguc ucaagagcau ccagaacgug      600

ucccaucuua uucugcacau gaaacagcau aucuugcuac uggagauauu uguugaugug      660

accucuagcg ucgagugucu cgaacugcgu gacacggauc uugacacuuu ccacuuuuca      720

gagcugagua ccggcgaaac aaauuccuug auuaagaaau ucacuuuuag aaacgugaag      780

aucaccgaug agagccucuu ccagguaaug aagcuguuaa accaaauuuc uggccugcua      840

gaacucgagu uugacgacug cacacugaau gggguuggaa acuucagggc uucagauaau      900

gaccggguga ucgauccugg uaaagucgag acccuuacga uccgcagauu gcacauucca      960

agguucuauc uguuuuacga ccucaguacu cuguauagcc uuacagaacg ggugaagcgc     1020

auaaccgugg agaacuccaa agucuuccug guucccuguu ugcucucuca gcaucugaag     1080

ucguuagaau accuggaucu aagcgagaau cucauggugg aagaguaccu gaaaaacucc     1140

gccugcgagg acgcauggcc uucacuucag acuuugaucc ugcgacagaa ucaccucgcc     1200

agucuggaaa agacaggcga gaccuuacug acgcuuaaaa acuugaccaa uauugauauc     1260

ucuaagaaca gcuuucauuc caugccagaa acaugucaau ggcccgagaa gaugaaauau     1320

cucaaucugu caagcacuag aauacacucu guaaccgggu gcauuccuaa gacacuagaa     1380

auccuggacg uguccaacaa uaaccucaau cuguucaguc uuaacuugcc acagcugaaa     1440

gaguuauaca ucagcaggaa caagcucaug acucugccgg augcuucucu ucugcccaug     1500

uugcucgucc ugaaaauuuc ccggaaugca aucaccacau uuucaaagga gcagcuagac     1560

aguuuccaca cccugaagac ucucgaagcc ggaggcaaca auuuuauuug uagcugcgag     1620

uuccugucgu uuacgcaaga acagcaggcu cuugccaaag uguugauaga uuggccugcg     1680

aacuaucugu gugacucccc aucucauguu cguggucagc aagugcagga cguccgcuua     1740

agcgugucag agugccacag aacagcacuc guaaguggga ugugcugugc ccuguuccuu     1800

cugauccuac ucaccggagu ucugugccau agguuucacg gcuuguggua caugaagaug     1860

augugggcuu ggcugcaggc caaacggaag ccccgaaaag caccuucccg caauauuugu     1920

uaugaugcuu ucgugucuua cagcgagaga gacgccuauu gggucgaaaa cuuaauggug     1980

caggagcucg aaaauuuuaa cccacccuuc aagcugugcc uucauaagag ggauuucauc     2040

ccgggcaaau ggaucauuga caauauaauc gauuccauug agaagucaca caaaacuguc     2100

uuugugcuga gcgaaaacuu cguuaagagu gaguggugua aauacgaguu ggacuuuucu     2160

cacuuccggc ucuuugauga aaauaacgac gcggccaucc ugauucuacu ggagccuauc     2220

gaaaagaagg caauacccca acgcuucugc aaacuuagaa agaucaugaa uaccaaaaca     2280

uaccucgagu ggccaaugga ugaagcucag agggaggggu uuugggugaa ccugcgugcc     2340

gcuauuaagu ccuga                                                      2355


<210>  9583
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR2__Homo_sapiens__AAC34377

<400>  9583
augccccaca cccuguggau ggugugggug cugggcguga ucaucagccu gagcaaggag       60

gagagcagca accaggccag ccugagcugc gacagaaacg gcaucugcaa gggcagcagc      120

ggcagccuga acagcauccc cagcggccug accgaggccg ugaagagccu ggaccugagc      180

aacaacagaa ucaccuacau cagcaacagc gaccugcaga gaugcgugaa ccugcaggcc      240

cuggugcuga ccagcaacgg caucaacacc aucgaggagg acagcuucag cagccugggc      300

agccuggagc accuggaccu gagcuacaac uaccugagca accugagcag cagcugguuc      360

aagccccuga gcagccugac cuuccugaac cugcugggca accccuacaa gacccugggc      420

gagaccagcc uguucagcca ccugaccaag cugcagaucc ugagaguggg caacauggac      480

accuucacca agauccagag aaaggacuuc gccggccuga ccuuccugga ggagcuggag      540

aucgacgcca gcgaccugca gagcuacgag cccaagagcc ugaagagcau ccagaacgug      600

agccaccuga uccugcacau gaagcagcac auccugcugc uggagaucuu cguggacgug      660

accagcagcg uggagugccu ggagcugaga gacaccgacc uggacaccuu ccacuucagc      720

gagcugagca ccggcgagac caacagccug aucaagaagu ucaccuucag aaacgugaag      780

aucaccgacg agagccuguu ccaggugaug aagcugcuga accagaucag cggccugcug      840

gagcuggagu ucgacgacug cacccugaac ggcgugggca acuucagagc cagcgacaac      900

gacagaguga ucgaccccgg caagguggag acccugacca ucagaagacu gcacaucccc      960

agauucuacc uguucuacga ccugagcacc cuguacagcc ugaccgagag agugaagaga     1020

aucaccgugg agaacagcaa gguguuccug gugcccugcc ugcugagcca gcaccugaag     1080

agccuggagu accuggaccu gagcgagaac cugauggugg aggaguaccu gaagaacagc     1140

gccugcgagg acgccuggcc cagccugcag acccugaucc ugagacagaa ccaccuggcc     1200

agccuggaga agaccggcga gacccugcug acccugaaga accugaccaa caucgacauc     1260

agcaagaaca gcuuccacag caugcccgag accugccagu ggcccgagaa gaugaaguac     1320

cugaaccuga gcagcaccag aauccacagc gugaccggcu gcauccccaa gacccuggag     1380

auccuggacg ugagcaacaa caaccugaac cuguucagcc ugaaccugcc ccagcugaag     1440

gagcuguaca ucagcagaaa caagcugaug acccugcccg acgccagccu gcugcccaug     1500

cugcuggugc ugaagaucag cagaaacgcc aucaccaccu ucagcaagga gcagcuggac     1560

agcuuccaca cccugaagac ccuggaggcc ggcggcaaca acuucaucug cagcugcgag     1620

uuccugagcu ucacccagga gcagcaggcc cuggccaagg ugcugaucga cuggcccgcc     1680

aacuaccugu gcgacagccc cagccacgug agaggccagc aggugcagga cgugagacug     1740

agcgugagcg agugccacag aaccgcccug gugagcggca ugugcugcgc ccuguuccug     1800

cugauccugc ugaccggcgu gcugugccac agauuccacg gccuguggua caugaagaug     1860

augugggccu ggcugcaggc caagagaaag cccagaaagg cccccagcag aaacaucugc     1920

uacgacgccu ucgugagcua cagcgagaga gacgccuacu ggguggagaa ccugauggug     1980

caggagcugg agaacuucaa cccccccuuc aagcugugcc ugcacaagag agacuucauc     2040

cccggcaagu ggaucaucga caacaucauc gacagcaucg agaagagcca caagaccgug     2100

uucgugcuga gcgagaacuu cgugaagagc gaguggugca aguacgagcu ggacuucagc     2160

cacuucagac uguucgacga gaacaacgac gccgccaucc ugauccugcu ggagcccauc     2220

gagaagaagg ccauccccca gagauucugc aagcugagaa agaucaugaa caccaagacc     2280

uaccuggagu ggcccaugga cgaggcccag agagagggcu ucugggugaa ccugagagcc     2340

gccaucaaga gcuga                                                      2355


<210>  9584
<211>  2355
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR2__Homo_sapiens__AAC34377

<400>  9584
augccccaca cccuguggau gguguggguc cucggcguua ucauuagccu guccaaggag       60

gaaucuagca accaggccuc ccuuucuugc gacagaaaug ggaucuguaa aggaagcucc      120

ggcucucuga acagcauucc uuccgggcuc acagaggcug ucaagagccu ggaucuuucu      180

aauaaccgga ucacguacau uuccaauagc gaccugcaac gcugcgugaa ccuccaggcc      240

cuggugcuga ccucuaaugg aaucaacaca aucgaagagg auuccuucag cucucucggc      300

ucccuggaac aucuugaccu gagcuauaau uaccucucca accugucuag cuccugguuu      360

aaaccgcuua gcucucugac cuuccucaau cugcugggga accccuauaa gacacucgga      420

gagaccuccc uguuuagcca ccuuacaaaa cugcagauuc ucagaguggg caauauggau      480

accuucacga agauccagcg gaaggacuuu gcgggccuga ccuuccuuga ggaacuggag      540

auugaugcuu cugaccucca aagcuacgaa ccuaaauccc ugaagucuau ccagaacguu      600

agccaucuga uucuccacau gaaacagcau auccugcuuc uggagauuuu uguggauguc      660

acauccagcg uggagugucu cgaacugcgc gacaccgauc uugacacauu ccacuuuucu      720

gagcugucca ccggggaaac gaauagccuc aucaagaaau ucacauuuag aaacguuaag      780

aucaccgaug agucucuguu ccaggugaug aagcugcuca accaaauuuc cggacugcuu      840

gaacuggagu uugacgacug cacacucaau ggcgucggga acuuccgggc cagcgauaau      900

gaccgcguga ucgaucccgg aaaaguggag acccugacca uuagacggcu gcacaucccu      960

cgcuucuauc ucuuuuacga ccuuuccaca cuguauucuc ugacggaaag agucaagcgg     1020

auuaccguug agaacagcaa aguguuccuc gugcccuguc ugcuuuccca gcaucugaag     1080

ucucucgaau accuggaucu gagcgagaau cuuauggucg aagaguaccu caaaaacucc     1140

gccugcgagg acgcuuggcc uagccugcag acacugaucc uccgccagaa ucaccuggcc     1200

ucucuugaaa agaccggcga gacacugcuc acccugaaaa accugacgaa uaucgauauu     1260

uccaagaaca gcuuucauuc uaugccggaa acaugucaau ggcccgagaa gaugaaauau     1320

cuuaaucucu ccagcaccag aauccacucu gugaccgggu gcauuccuaa gacacuggaa     1380

auccuggacg uuagcaacaa uaaccucaau cuguucuccc uuaaccugcc ccagcucaaa     1440

gagcuguaca uuagccggaa caagcugaug acccuuccug augcuucucu ccugcccaug     1500

cugcucgugc ugaaaaucuc ccgcaaugcc aucacaacgu uuagcaagga gcagcuugac     1560

uccuuccaca cccugaagac acucgaagcg ggaggcaaca auuuuauuug uucuugcgag     1620

uuccugagcu uuacccaaga acagcaggcc cuggcuaaag uccuuaucga uuggccggcc     1680

aacuaucugu gugacucccc uucucaugug agaggccagc aaguucagga cgugcggcuc     1740

agcgucuccg agugccacag aacagcucug gugucuggga ugugcugugc ccucuuccug     1800

cuuauucugc ucaccggagu ccugugccau cgcuuucacg gccuguggua caugaagaug     1860

augugggcgu ggcuucaggc caaacggaag cccagaaaag cuccuagccg caauaucugu     1920

uaugaugccu ucguguccua cagcgagcgg gacgcuuauu ggguugaaaa ccugauggug     1980

caggagcucg aaaauuuuaa cccucccuuc aagcugugcc uccauaagag agauuucauu     2040

cccgggaaau ggaucauuga caauaucauc gauucuauug agaaguccca caaaacgguc     2100

uuugugcuga gcgaaaacuu cguuaagucu gaguggugua aauacgagcu ugacuuuucc     2160

cacuuccgcc uguuugauga aaauaacgac gccgccaucc ucauucugcu ggagccgauc     2220

gaaaagaagg cuauucccca acgguucugc aaacuuagaa agaucaugaa uaccaaaaca     2280

uaccuggagu ggccuaugga ugaagcgcag cgcgagggau uuugggugaa ccuccgggcc     2340

gcuaucaaga gcuga                                                      2355


<210>  9585
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR3__Homo_sapiens__O15455

<400>  9585

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  9586
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR3__Homo_sapiens__AAC34134

<400>  9586
augagacaga cuuugccuug uaucuacuuu ugggggggcc uuuugcccuu ugggaugcug       60

ugugcauccu ccaccaccaa gugcacuguu agccaugaag uugcugacug cagccaccug      120

aaguugacuc agguacccga ugaucuaccc acaaacauaa caguguugaa ccuuacccau      180

aaucaacuca gaagauuacc agccgccaac uucacaaggu auagccagcu aacuagcuug      240

gauguaggau uuaacaccau cucaaaacug gagccagaau ugugccagaa acuucccaug      300

uuaaaaguuu ugaaccucca gcacaaugag cuaucucaac uuucugauaa aaccuuugcc      360

uucugcacga auuugacuga acuccaucuc auguccaacu caauccagaa aauuaaaaau      420

aaucccuuug ucaagcagaa gaauuuaauc acauuagauc ugucucauaa uggcuuguca      480

ucuacaaaau uaggaacuca gguucagcug gaaaaucucc aagagcuucu auuaucaaac      540

aauaaaauuc aagcgcuaaa aagugaagaa cuggauaucu uugccaauuc aucuuuaaaa      600

aaauuagagu ugucaucgaa ucaaauuaaa gaguuuucuc caggguguuu ucacgcaauu      660

ggaagauuau uuggccucuu ucugaacaau guccagcugg gucccagccu uacagagaag      720

cuauguuugg aauuagcaaa cacaagcauu cggaaucugu cucugaguaa cagccagcug      780

uccaccacca gcaauacaac uuucuuggga cuaaagugga caaaucucac uaugcucgau      840

cuuuccuaca acaacuuaaa ugugguuggu aacgauuccu uugcuuggcu uccacaacua      900

gaauauuucu uccuagagua uaauaauaua cagcauuugu uuucucacuc uuugcacggg      960

cuuuucaaug ugagguaccu gaauuugaaa cggucuuuua cuaaacaaag uauuucccuu     1020

gccucacucc ccaagauuga ugauuuuucu uuucaguggc uaaaauguuu ggagcaccuu     1080

aacauggaag auaaugauau uccaggcaua aaaagcaaua uguucacagg auugauaaac     1140

cugaaauacu uaagucuauc caacuccuuu acaaguuugc gaacuuugac aaaugaaaca     1200

uuuguaucac uugcucauuc ucccuuacac auacucaacc uaaccaagaa uaaaaucuca     1260

aaaauagaga gugaugcuuu cucuugguug ggccaccuag aaguacuuga ccugggccuu     1320

aaugaaauug ggcaagaacu cacaggccag gaauggagag gucuagaaaa uauuuucgaa     1380

aucuaucuuu ccuacaacaa guaccugcag cugacuagga acuccuuugc cuugguccca     1440

agccuucaac gacugaugcu ccgaagggug gcccuuaaaa auguggauag cucuccuuca     1500

ccauuccagc cucuucguaa cuugaccauu cuggaucuaa gcaacaacaa cauagccaac     1560

auaaaugaug acauguugga gggucuugag aaacuagaaa uucucgauuu gcagcauaac     1620

aacuuagcac ggcucuggaa acacgcaaac ccuggugguc ccauuuauuu ccuaaagggu     1680

cugucucacc uccacauccu uaacuuggag uccaacggcu uugacgagau cccaguugag     1740

gucuucaagg auuuauuuga acuaaagauc aucgauuuag gauugaauaa uuuaaacaca     1800

cuuccagcau cugucuuuaa uaaucaggug ucucuaaagu cauugaaccu ucagaagaau     1860

cucauaacau ccguugagaa gaagguuuuc gggccagcuu ucaggaaccu gacugaguua     1920

gauaugcgcu uuaaucccuu ugauugcacg ugugaaagua uugccugguu uguuaauugg     1980

auuaacgaga cccauaccaa caucccugag cugucaagcc acuaccuuug caacacucca     2040

ccucacuauc auggguuccc agugagacuu uuugauacau caucuugcaa agacagugcc     2100

cccuuugaac ucuuuuucau gaucaauacc aguauccugu ugauuuuuau cuuuauugua     2160

cuucucaucc acuuugaggg cuggaggaua ucuuuuuauu ggaauguuuc aguacaucga     2220

guucuugguu ucaaagaaau agacagacag acagaacagu uugaauaugc agcauauaua     2280

auucaugccu auaaagauaa ggauuggguc ugggaacauu ucucuucaau ggaaaaggaa     2340

gaccaaucuc ucaaauuuug ucuggaagaa agggacuuug aggcgggugu uuuugaacua     2400

gaagcaauug uuaacagcau caaaagaagc agaaaaauua uuuuuguuau aacacaccau     2460

cuauuaaaag acccauuaug caaaagauuc aagguacauc augcaguuca acaagcuauu     2520

gaacaaaauc uggauuccau uauauugguu uuccuugagg agauuccaga uuauaaacug     2580

aaccaugcac ucuguuugcg aagaggaaug uuuaaaucuc acugcaucuu gaacuggcca     2640

guucagaaag aacggauagg ugccuuucgu cauaaauugc aaguagcacu uggauccaaa     2700

aacucuguac auuaa                                                      2715


<210>  9587
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR3__Homo_sapiens__AAC34134

<400>  9587
augcgccaga cccugcccug caucuacuuc uggggcgggc uccugccguu cggcaugcug       60

ugcgccagcu ccaccacgaa gugcaccgug agccacgagg ucgccgacug cucccaccuc      120

aagcugaccc aggugcccga cgaccugccc accaacauca cggugcucaa ccugacccac      180

aaccagcugc ggcgccuccc cgcggccaac uucacccggu acagccagcu gaccucccug      240

gacgucgggu ucaacacgau cagcaagcuc gagccggagc ugugccagaa gcugcccaug      300

cucaaggugc ugaaccugca gcacaacgag cucucccagc ugagcgacaa gaccuucgcc      360

uucugcacca accugaccga gcuccaccug auguccaaca gcauccagaa gaucaagaac      420

aaccccuucg ugaagcagaa gaaccugauc acgcucgacc ugucccacaa cggccugagc      480

uccaccaagc ucgggaccca gguccagcug gagaaccugc aggagcuccu gcugagcaac      540

aacaagaucc aggcccucaa guccgaggag cuggacaucu ucgccaacag cucccugaag      600

aagcucgagc ugagcuccaa ccagaucaag gaguucagcc ccggcugcuu ccacgcgauc      660

ggccgccugu ucggccucuu ccugaacaac gugcagcugg ggccgagccu caccgagaag      720

cugugccugg agcucgccaa cacguccauc cggaaccuga gccuguccaa cagccagcuc      780

uccaccacca gcaacaccac guuccugggg cugaagugga ccaaccugac caugcucgac      840

cuguccuaca acaaccugaa cguggucggc aacgacagcu ucgccuggcu cccccagcug      900

gaguacuucu uccuggagua caacaacauc cagcaccucu ucucccacag ccugcacggg      960

cuguucaacg ugcgcuaccu caaccugaag cgguccuuca ccaagcagag caucucccug     1020

gccagccucc ccaagaucga cgacuucucc uuccaguggc ugaagugccu ggagcaccuc     1080

aacauggagg acaacgacau ccccggcauc aagagcaaca uguucacggg ccugaucaac     1140

cugaaguacc ucucccugag caacuccuuc accagccugc gcacccucac caacgagacg     1200

uucgugagcc uggcgcacuc cccgcugcac auccucaacc ugaccaagaa caagaucagc     1260

aagaucgagu ccgacgccuu cagcuggcug gggcaccucg agguccugga ccugggccuc     1320

aacgagaucg ggcaggagcu gaccggccag gaguggcggg gccuggagaa caucuucgag     1380

aucuaccucu ccuacaacaa guaccugcag cugacccgca acagcuucgc ccucgugccc     1440

ucccugcagc ggcugaugcu ccgccgggug gcccugaaga acgucgacag cucccccagc     1500

cccuuccagc cgcugcgcaa ccucacgauc cuggaccugu ccaacaacaa caucgccaac     1560

aucaacgacg acaugcucga ggggcuggag aagcuggaga uccucgaccu gcagcacaac     1620

aaccuggcgc ggcucuggaa gcacgccaac cccggcgggc ccaucuacuu ccugaagggc     1680

cugagccacc uccacauccu gaaccuggag uccaacgggu ucgacgagau ccccguggag     1740

guguucaagg accucuucga gcugaagauc aucgaccugg gccucaacaa ccugaacacc     1800

cugccggcca gcgucuucaa caaccaggug ucccucaaga gccugaaccu gcagaagaac     1860

cucaucaccu ccguggagaa gaaggucuuc ggccccgccu uccgcaaccu gaccgagcug     1920

gacaugcggu ucaaccccuu cgacugcacg ugcgagagca ucgccugguu cgugaacugg     1980

aucaacgaga cccacaccaa cauccccgag cucagcuccc acuaccugug caacaccccg     2040

ccccacuacc acggguuccc cgugcgccug uucgacacca gcuccugcaa ggacagcgcg     2100

cccuucgagc uguucuucau gaucaacacg uccauccugc ugaucuucau cuucaucguc     2160

cuccugaucc acuucgaggg cuggcggauc agcuucuacu ggaacguguc cguccaccgc     2220

gugcuggggu ucaaggagau cgaccggcag accgagcagu ucgaguacgc cgccuacauc     2280

auccacgccu acaaggacaa ggacugggug ugggagcacu ucagcuccau ggagaaggag     2340

gaccagagcc ucaaguucug ccuggaggag cgcgacuucg aggccggcgu cuucgagcug     2400

gaggcgaucg ugaacuccau caagcgcagc cggaagauca ucuucgugau cacccaccac     2460

cuccugaagg acccgcugug caagcgcuuc aagguccacc acgccgugca gcaggccauc     2520

gagcagaacc ucgacuccau cauccuggug uuccuggagg agauccccga cuacaagcuc     2580

aaccacgccc ugugccugcg gcgcgggaug uucaagagcc acugcauccu caacuggccc     2640

guccagaagg agcggaucgg cgccuuccgc cacaagcucc agguggcgcu gggcuccaag     2700

aacagcgugc acuga                                                      2715


<210>  9588
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR3__Homo_sapiens__AAC34134

<400>  9588
augcgccaga cccuccccug caucuacuuc uggggcggcc uccuccccuu cggcaugcuc       60

ugcgccuccu ccaccaccaa gugcaccguc ucccacgagg ucgccgacug cucccaccuc      120

aagcucaccc agguccccga cgaccucccc accaacauca ccguccucaa ccucacccac      180

aaccagcucc gccgccuccc cgccgccaac uucacccgcu acucccagcu caccucccuc      240

gacgucggcu ucaacaccau cuccaagcuc gagcccgagc ucugccagaa gcuccccaug      300

cucaaggucc ucaaccucca gcacaacgag cucucccagc ucuccgacaa gaccuucgcc      360

uucugcacca accucaccga gcuccaccuc auguccaacu ccauccagaa gaucaagaac      420

aaccccuucg ucaagcagaa gaaccucauc acccucgacc ucucccacaa cggccucucc      480

uccaccaagc ucggcaccca gguccagcuc gagaaccucc aggagcuccu ccucuccaac      540

aacaagaucc aggcccucaa guccgaggag cucgacaucu ucgccaacuc cucccucaag      600

aagcucgagc ucuccuccaa ccagaucaag gaguucuccc ccggcugcuu ccacgccauc      660

ggccgccucu ucggccucuu ccucaacaac guccagcucg gccccucccu caccgagaag      720

cucugccucg agcucgccaa caccuccauc cgcaaccucu cccucuccaa cucccagcuc      780

uccaccaccu ccaacaccac cuuccucggc cucaagugga ccaaccucac caugcucgac      840

cucuccuaca acaaccucaa cgucgucggc aacgacuccu ucgccuggcu cccccagcuc      900

gaguacuucu uccucgagua caacaacauc cagcaccucu ucucccacuc ccuccacggc      960

cucuucaacg uccgcuaccu caaccucaag cgcuccuuca ccaagcaguc caucucccuc     1020

gccucccucc ccaagaucga cgacuucucc uuccaguggc ucaagugccu cgagcaccuc     1080

aacauggagg acaacgacau ccccggcauc aaguccaaca uguucaccgg ccucaucaac     1140

cucaaguacc ucucccucuc caacuccuuc accucccucc gcacccucac caacgagacc     1200

uucgucuccc ucgcccacuc cccccuccac auccucaacc ucaccaagaa caagaucucc     1260

aagaucgagu ccgacgccuu cuccuggcuc ggccaccucg agguccucga ccucggccuc     1320

aacgagaucg gccaggagcu caccggccag gaguggcgcg gccucgagaa caucuucgag     1380

aucuaccucu ccuacaacaa guaccuccag cucacccgca acuccuucgc ccucgucccc     1440

ucccuccagc gccucaugcu ccgccgcguc gcccucaaga acgucgacuc cucccccucc     1500

cccuuccagc cccuccgcaa ccucaccauc cucgaccucu ccaacaacaa caucgccaac     1560

aucaacgacg acaugcucga gggccucgag aagcucgaga uccucgaccu ccagcacaac     1620

aaccucgccc gccucuggaa gcacgccaac cccggcggcc ccaucuacuu ccucaagggc     1680

cucucccacc uccacauccu caaccucgag uccaacggcu ucgacgagau ccccgucgag     1740

gucuucaagg accucuucga gcucaagauc aucgaccucg gccucaacaa ccucaacacc     1800

cuccccgccu ccgucuucaa caaccagguc ucccucaagu cccucaaccu ccagaagaac     1860

cucaucaccu ccgucgagaa gaaggucuuc ggccccgccu uccgcaaccu caccgagcuc     1920

gacaugcgcu ucaaccccuu cgacugcacc ugcgagucca ucgccugguu cgucaacugg     1980

aucaacgaga cccacaccaa cauccccgag cucuccuccc acuaccucug caacaccccc     2040

ccccacuacc acggcuuccc cguccgccuc uucgacaccu ccuccugcaa ggacuccgcc     2100

cccuucgagc ucuucuucau gaucaacacc uccauccucc ucaucuucau cuucaucguc     2160

cuccucaucc acuucgaggg cuggcgcauc uccuucuacu ggaacgucuc cguccaccgc     2220

guccucggcu ucaaggagau cgaccgccag accgagcagu ucgaguacgc cgccuacauc     2280

auccacgccu acaaggacaa ggacuggguc ugggagcacu ucuccuccau ggagaaggag     2340

gaccaguccc ucaaguucug ccucgaggag cgcgacuucg aggccggcgu cuucgagcuc     2400

gaggccaucg ucaacuccau caagcgcucc cgcaagauca ucuucgucau cacccaccac     2460

cuccucaagg acccccucug caagcgcuuc aagguccacc acgccgucca gcaggccauc     2520

gagcagaacc ucgacuccau cauccucguc uuccucgagg agauccccga cuacaagcuc     2580

aaccacgccc ucugccuccg ccgcggcaug uucaaguccc acugcauccu caacuggccc     2640

guccagaagg agcgcaucgg cgccuuccgc cacaagcucc aggucgcccu cggcuccaag     2700

aacuccgucc acuga                                                      2715


<210>  9589
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR3__Homo_sapiens__AAC34134

<400>  9589
augagacaga cccugcccug caucuacuuc uggggcgggc uccuuccuuu uggaaugcug       60

ugugccagcu ccacaacuaa gugcacggug ucucacgagg ucgcugacug uucacauuug      120

aaauuaaccc aaguuccaga ugaccugccg acaaacauua cugugcuaaa ucucacccac      180

aaccagcuga ggcggcuucc cgcagccaau uucacacgcu auagucagcu gaccagcuug      240

gauguagguu uuaacacuau auccaagcuc gaaccugagc ugugccagaa acugccaaug      300

cucaaggugu uaaaucugca acauaacgaa cuuucucagu ugucggacaa aacauucgcg      360

uuuuguacca aucugacgga gcuacaccuc augucaaaca gcauccagaa gauuaagaau      420

aaccccuucg ucaaacagaa gaaucugauc acucuugauc ugagucauaa cggcuugucc      480

ucuaccaaac ucgggacaca agugcagcug gaaaauuuac aggagcugcu ccuuagcaac      540

aauaagauuc aggcucugaa auccgaggaa uuggacaucu uugccaacuc aagucuaaag      600

aagcuggagc ucagcucuaa ccaaauaaaa gaguucuccc cuggaugcuu ucacgcaauc      660

ggccgacugu ucggucuuuu ucugaauaac guucaguugg ggccaucacu cacugaaaag      720

cuguguuuag agcuggccaa uaccagcauu cguaaccuaa gucucucuaa uucccagcug      780

agcacaaccu cgaacacgac uuuccuugga uugaaaugga caaaucugac caugcucgau      840

cugucuuaca acaaucuuaa cguggucggc aaugacuccu uugcuuggcu gccccaauug      900

gaauauuucu uccucgagua caacaauauc cagcaccugu uuucacauag uuuacacggc      960

cuguucaacg ugagauaucu aaaucucaag aggagcuuua cuaaacaguc cauuucucug     1020

gcaagccuuc cuaagaucga ugacuucuca uuucaguggu ugaaaugccu ggaacaucuc     1080

aacauggagg auaacgacau accagggauu aagaguaaua uguucacagg acugaucaac     1140

uuaaaguacc ugucccuuag caauucuuuu accucauugc ggacgcucac caacgaaaca     1200

uucguaaguc uggcccacag cccgcuacac auucugaauc ucacuaaaaa caagaucucc     1260

aaaaucgagu cugaugcuuu uucguggcug ggucaucuug agguuuugga ccugggcuua     1320

aaugaaauug ggcaagagcu caccggacag gaauggcgcg gccuggagaa cauauucgaa     1380

aucuaucuua gcuacaauaa guaccugcag uugacaagaa acuccuuugc ccucgugccc     1440

ucacugcaga ggcuaaugcu gcggcgcguc gcgcucaaaa auguggacag uucuccuagc     1500

ccauuccaac cccugcgaaa ccuuacuauu uuggaucugu ccaauaacaa uaucgcaaac     1560

auaaacgacg auauguuaga gggucucgag aagcuggaaa uucuugaccu gcagcacaau     1620

aaccuagcca gacucuggaa gcaugcuaau ccugggggac caaucuauuu ucugaaaggc     1680

uugucacauc ugcacaucuu aaaccucgag agcaauggcu ucgaugaaau ucccguggag     1740

gucuucaagg accuguuuga acuuaaaauc auugaucugg gguugaacaa ucucaacacc     1800

cugccggccu cuguuuucaa uaaccaggug ucccuaaaga gucugaaucu ucagaaaaac     1860

cucauaacaa gcguagagaa gaagguguuu ggaccugcau ucaggaaucu gaccgaguug     1920

gacaugcggu uuaaccccuu cgauuguacu ugcgaaucua ucgcuugguu ugucaauugg     1980

auuaacgaga cgcacacaaa caucccagaa cuguccucac acuacuuaug uaauaccccu     2040

ccccauuauc acgguuuccc agugcgucuc uuugacacca guagcugcaa agauucggcc     2100

cccuucgagc uguuuuucau gaucaacacu uccauucuuc ugauauuuau cuucauuguu     2160

uugcucaucc auuucgaggg cuggcgcauu ucuuuuuacu ggaaugugag cguccacaga     2220

gugcuggggu ucaaggaaau cgacaggcaa acagagcagu uugaauaugc ggccuacaua     2280

auccacgcau auaaagacaa ggauugggua ugggagcauu ucucaaguau ggaaaaagag     2340

gaccaguccc uaaaguuuug ccuggaggaa cgggauuucg aggcuggagu uuuugaacuu     2400

gaggccauug ugaacucuau caagcgaagc cgcaaaauua ucuucgucau aacccaccau     2460

cuccugaagg acccuuugug uaaaagauuu aaggugcacc augcugucca gcaagccauu     2520

gaacagaauu uagauuccau cauucuggug uuccucgagg agaucccaga cuacaaacug     2580

aaccacgcac uuugccugag gcggggcaug uuuaagucac acuguauauu gaauuggccg     2640

guucagaaag aacgcaucgg ugccuucaga cauaagcuac aaguggcucu ggggagcaag     2700

aacaguguac acuga                                                      2715


<210>  9590
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR3__Homo_sapiens__AAC34134

<400>  9590
augagacaga cccugcccug caucuacuuc uggggcggcc ugcugcccuu cggcaugcug       60

ugcgccagca gcaccaccaa gugcaccgug agccacgagg uggccgacug cagccaccug      120

aagcugaccc aggugcccga cgaccugccc accaacauca ccgugcugaa ccugacccac      180

aaccagcuga gaagacugcc cgccgccaac uucaccagau acagccagcu gaccagccug      240

gacgugggcu ucaacaccau cagcaagcug gagcccgagc ugugccagaa gcugcccaug      300

cugaaggugc ugaaccugca gcacaacgag cugagccagc ugagcgacaa gaccuucgcc      360

uucugcacca accugaccga gcugcaccug augagcaaca gcauccagaa gaucaagaac      420

aaccccuucg ugaagcagaa gaaccugauc acccuggacc ugagccacaa cggccugagc      480

agcaccaagc ugggcaccca ggugcagcug gagaaccugc aggagcugcu gcugagcaac      540

aacaagaucc aggcccugaa gagcgaggag cuggacaucu ucgccaacag cagccugaag      600

aagcuggagc ugagcagcaa ccagaucaag gaguucagcc ccggcugcuu ccacgccauc      660

ggcagacugu ucggccuguu ccugaacaac gugcagcugg gccccagccu gaccgagaag      720

cugugccugg agcuggccaa caccagcauc agaaaccuga gccugagcaa cagccagcug      780

agcaccacca gcaacaccac cuuccugggc cugaagugga ccaaccugac caugcuggac      840

cugagcuaca acaaccugaa cguggugggc aacgacagcu ucgccuggcu gccccagcug      900

gaguacuucu uccuggagua caacaacauc cagcaccugu ucagccacag ccugcacggc      960

cuguucaacg ugagauaccu gaaccugaag agaagcuuca ccaagcagag caucagccug     1020

gccagccugc ccaagaucga cgacuucagc uuccaguggc ugaagugccu ggagcaccug     1080

aacauggagg acaacgacau ccccggcauc aagagcaaca uguucaccgg ccugaucaac     1140

cugaaguacc ugagccugag caacagcuuc accagccuga gaacccugac caacgagacc     1200

uucgugagcc uggcccacag cccccugcac auccugaacc ugaccaagaa caagaucagc     1260

aagaucgaga gcgacgccuu cagcuggcug ggccaccugg aggugcugga ccugggccug     1320

aacgagaucg gccaggagcu gaccggccag gaguggagag gccuggagaa caucuucgag     1380

aucuaccuga gcuacaacaa guaccugcag cugaccagaa acagcuucgc ccuggugccc     1440

agccugcaga gacugaugcu gagaagagug gcccugaaga acguggacag cagccccagc     1500

cccuuccagc cccugagaaa ccugaccauc cuggaccuga gcaacaacaa caucgccaac     1560

aucaacgacg acaugcugga gggccuggag aagcuggaga uccuggaccu gcagcacaac     1620

aaccuggcca gacuguggaa gcacgccaac cccggcggcc ccaucuacuu ccugaagggc     1680

cugagccacc ugcacauccu gaaccuggag agcaacggcu ucgacgagau ccccguggag     1740

guguucaagg accuguucga gcugaagauc aucgaccugg gccugaacaa ccugaacacc     1800

cugcccgcca gcguguucaa caaccaggug agccugaaga gccugaaccu gcagaagaac     1860

cugaucacca gcguggagaa gaagguguuc ggccccgccu ucagaaaccu gaccgagcug     1920

gacaugagau ucaaccccuu cgacugcacc ugcgagagca ucgccugguu cgugaacugg     1980

aucaacgaga cccacaccaa cauccccgag cugagcagcc acuaccugug caacaccccc     2040

ccccacuacc acggcuuccc cgugagacug uucgacacca gcagcugcaa ggacagcgcc     2100

cccuucgagc uguucuucau gaucaacacc agcauccugc ugaucuucau cuucaucgug     2160

cugcugaucc acuucgaggg cuggagaauc agcuucuacu ggaacgugag cgugcacaga     2220

gugcugggcu ucaaggagau cgacagacag accgagcagu ucgaguacgc cgccuacauc     2280

auccacgccu acaaggacaa ggacugggug ugggagcacu ucagcagcau ggagaaggag     2340

gaccagagcc ugaaguucug ccuggaggag agagacuucg aggccggcgu guucgagcug     2400

gaggccaucg ugaacagcau caagagaagc agaaagauca ucuucgugau cacccaccac     2460

cugcugaagg acccccugug caagagauuc aaggugcacc acgccgugca gcaggccauc     2520

gagcagaacc uggacagcau cauccuggug uuccuggagg agauccccga cuacaagcug     2580

aaccacgccc ugugccugag aagaggcaug uucaagagcc acugcauccu gaacuggccc     2640

gugcagaagg agagaaucgg cgccuucaga cacaagcugc agguggcccu gggcagcaag     2700

aacagcgugc acuga                                                      2715


<210>  9591
<211>  2715
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR3__Homo_sapiens__AAC34134

<400>  9591
augagacaga cccugcccug caucuacuuc uggggcgggc uccugccuuu uggaaugcuu       60

ugugccagcu ccacaacgaa gugcaccgug ucucacgagg ucgcugacug uagccaucug      120

aaacucacac aaguuccgga ugaccugccc accaacauua cagugcuuaa ucugacccac      180

aaccagcucc ggcgccugcc ugccgcgaau uucacaagau auucccagcu gaccucucuc      240

gaugugggcu uuaacacgau cagcaagcug gaacccgagc uuugccagaa acugccuaug      300

cucaaggucc ugaaucuuca acauaacgaa cugucccagc ucucugacaa aaccuucgcu      360

uuuuguacaa aucugaccga gcugcaccuc augagcaacu ccauucagaa gaucaagaau      420

aaccccuucg ugaaacagaa gaaucugauu acacuugauc ugagccauaa cgggcucucu      480

uccaccaaac ugggaacgca aguucagcuu gaaaaucugc aggagcuccu gcugagcaac      540

aauaagaucc aggcccucaa aucugaggaa cuggacaucu uugccaacuc cagccuuaag      600

aagcuggagc ucucuuccaa ccaaauuaaa gaguucagcc cuggcugcuu ucacgcuauc      660

gggcggcugu ucggacuuuu ucugaauaac gugcagcucg gcccgucccu gacagaaaag      720

cugugucucg agcuggccaa uaccucuauu cgcaaccuua gccuguccaa uagccagcuc      780

ucuacaaccu ccaacaccac auuccugggc cugaaaugga cgaaucuuac caugcucgau      840

cugagcuaca acaaucugaa cgucgugggg aaugacucuu uugcuuggcu cccccaacug      900

gaauauuucu uccuugagua caacaauauc cagcaccugu uuagccauuc ccuccacgga      960

cuguucaacg uuagauaucu gaaucuuaag cggucuuuua caaaacagag cauuucccuc     1020

gccagccugc cuaagaucga ugacuucucu uuucaguggc ugaaaugccu cgaacaucug     1080

aacauggagg auaacgacau ucccggcauc aaguccaaua uguucaccgg gcuuaucaac     1140

cugaaguacc ucagccuguc uaauuccuuu acaagccugc gcacccuuac gaacgaaaca     1200

uucguguccc ucgcgcacuc uccucugcac auucugaauc ucaccaaaaa caagaucagc     1260

aaaauugagu ccgaugccuu uucuuggcug ggacaucuug agguccugga ccucggccug     1320

aaugaaaucg ggcaagagcu gaccggacag gaauggagag gccuugagaa cauuuucgaa     1380

aucuaucuca gcuacaauaa guaccugcag cugacacgga acuccuuugc ucucgugccc     1440

agccugcagc gccuuaugcu gagacgggug gcccucaaaa augucgacuc uuccccgagc     1500

ccuuuccaac cccugcgcaa ccugaccauc cuugaucugu cuaauaacaa uauugcuaac     1560

aucaacgacg auaugcucga gggccuggag aagcucgaaa uucuggaccu ucagcacaau     1620

aaccuggcca gacucuggaa gcaugcgaau ccugggggac ccaucuauuu ucugaaaggc     1680

cugucccacc uucauauucu gaaccucgag agcaaugggu ucgaugaaau ccccguugag     1740

guguucaagg accuguuuga acucaaaauc auugaucugg gacuuaacaa ucugaacaca     1800

cucccugccu cuguguucaa uaaccagguc agccugaagu cccugaaucu ucagaaaaac     1860

cugaucacga gcguggagaa gaagguuuuu ggcccggcuu uccggaaucu caccgagcug     1920

gacaugcgcu uuaaccccuu cgauuguaca ugcgaaucua uugccugguu ugugaauugg     1980

aucaacgaga cccacacaaa cauuccugaa cucuccagcc acuaccugug uaauacgccc     2040

ccucauuauc acggguuccc cgucagacuu uuugacaccu ccucuugcaa agauagcgcu     2100

ccguucgagc uguuuuucau gaucaacacc uccauucugc ucaucuuuau cuucauugug     2160

cugcuuaucc auuucgaggg auggcggauu ucuuuuuacu ggaauguuag cgugcacaga     2220

guccugggcu ucaaggaaau cgaccgccaa acagagcagu uugaauaugc cgccuacauu     2280

auccacgcuu auaaagacaa ggauugggug ugggagcauu ucuccucuau ggaaaaagag     2340

gaccagagcc ucaaguuuug ccuggaggaa cgggauuucg aggcgggcgu cuuugaacuc     2400

gaggccaucg ugaacuccau uaagagaagc cgcaaaauca uuuucguuau cacccaccau     2460

cugcuuaagg acccucugug uaaacgguuu aaggugcacc augcugucca gcaagccauu     2520

gaacagaauc uggauucuau cauccucgug uuccuggagg agauucccga cuacaaacuu     2580

aaccacgccc ugugccucag acgcgggaug uuuaaguccc acuguauccu gaauuggccu     2640

guucagaaag aacggauugg agcuuucaga cauaagcucc aaguggcccu gggcagcaag     2700

aacucugucc acuga                                                      2715


<210>  9592
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR4__Homo_sapiens__D1CS55

<400>  9592

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Tyr Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  9593
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR4__Homo_sapiens__AAY82270

<400>  9593
augaugucug ccucgcgccu ggcugggacu cugaucccag ccauggccuu ccucuccugc       60

gugagaccag aaagcuggga gcccugcgug gaggugguuc cuaauauuac uuaucaaugc      120

auggagcuga auuucuacaa aauccccgac aaccuccccu ucucaaccaa gaaccuggac      180

cugagcuuua auccccugag gcauuuaggc agcuauagcu ucuucaguuu cccagaacug      240

caggugcugg auuuauccag gugugaaauc cagacaauug aagauggggc auaucagagc      300

cuaagccacc ucucuaccuu aauauugaca ggaaacccca uccagaguuu agcccuggga      360

gccuuuucug gacuaucaag uuuacagaag cugguggcug uggagacaaa ucuagcaucu      420

cuagagaacu uccccauugg acaucucaaa acuuugaaag aacuuaaugu ggcucacaau      480

cuuauccaau cuuucaaauu accugaguau uuuucuaauc ugaccaaucu agagcacuug      540

gaccuuucca gcaacaagau ucaaaguauu uauugcacag acuugcgggu ucuacaucaa      600

augccccuac ucaaucucuc uuuagaccug ucccugaacc cuaugaacuu uauccaacca      660

ggugcauuua aagaaauuag gcuucauaag cugacuuuaa gaaauaauuu ugauaguuua      720

aauguaauga aaacuuguau ucaaggucug gcugguuuag aaguccaucg uuugguucug      780

ggagaauuua gaaaugaagg aaacuuggaa aaguuugaca aaucugcucu agagggccug      840

uacaauuuga ccauugaaga auuccgauua gcauacuuag acuacuaccu cgaugauauu      900

auugacuuau uuaauuguuu gacaaauguu ucuucauuuu cccuggugag ugugacuauu      960

gaaaggguaa aagacuuuuc uuauaauuuc ggauggcaac auuuagaauu aguuaacugu     1020

aaauuuggac aguuucccac auugaaacuc aaaucucuca aaaggcuuac uuucacuucc     1080

aacaaaggug ggaaugcuuu uucagaaguu gaucuaccaa gccuugaguu ucuagaucuc     1140

aguagaaaug gcuugaguuu caaagguugc uguucucaaa gugauuuugg gacaaccagc     1200

cuaaaguauu uagaucugag cuucaauggu guuauuacca ugaguucaaa cuucuugggc     1260

uuagaacaac uagaacaucu ggauuuccag cauuccaauu ugaaacaaau gagugaguuu     1320

ucaguauucc uaucacucag aaaccucauu uaccuugaca uuucucauac ucacaccaga     1380

guugcuuuca auggcaucuu caauggcuug uccagucucg aagucuugaa aauggcuggc     1440

aauucuuucc aggaaaacuu ccuuccagau aucuucacag agcugagaaa cuugaccuuc     1500

cuggaccucu cucaguguca acuggagcag uugucuccaa cagcauuuaa cucacucucc     1560

agucuucagg uacuaaauau gagccacaac aacuucuuuu cauuggauac guuuccuuau     1620

aagugucuga acucccucca gguucuugau uacagucuca aucacauaau gacuuccaaa     1680

aaacaggaac uacagcauuu uccaaguagu cuagcuuucu uaaaucuuac ucagaaugac     1740

uuugcuugua cuugugaaca ccagaguuuc cugcaaugga ucaaggacca gaggcagcuc     1800

uugguggaag uugaacgaau ggaaugugca acaccuucag auaagcaggg caugccugug     1860

cugaguuuga auaucaccug ucagaugaau aagaccauca uugguguguc gguccucagu     1920

gugcuuguag uaucuguugu agcaguucug gucuauaagu ucuauuuuca ccugaugcuu     1980

cuugcuggcu gcauaaagua ugguagaggu gaaaacaucu augaugccuu uguuaucuac     2040

ucaagccagg augaggacug gguaaggaau gagcuaguaa agaauuuaga agaaggggug     2100

ccuccauuuc agcucugccu ucacuacaga gacuuuauuc ccgguguggc cauugcugcc     2160

aacaucaucc augaagguuu ccauaaaagc cgaaagguga uuguuguggu gucccagcac     2220

uucauccaga gccgcuggug uaucuuugaa uaugagauug cucagaccug gcaguuucug     2280

agcagucgug cugguaucau cuucauuguc cugcagaagg uggagaagac ccugcucagg     2340

cagcaggugg agcuguaccg ccuucucagc aggaacacuu accuggagug ggaggacagu     2400

guccuggggc ggcacaucuu cuggagacga cucagaaaag cccugcugga ugguaaauca     2460

uggaauccag aaggaacagu ggguacagga ugcaauuggc aggaagcaac aucuaucuga     2520


<210>  9594
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR4__Homo_sapiens__AAY82270

<400>  9594
augaugagcg ccucccgccu ggccggcacc cucauccccg cgauggccuu ccugagcugc       60

gugcggccgg aguccuggga gcccugcguc gagguggugc ccaacaucac cuaccagugc      120

auggagcuga acuucuacaa gauccccgac aaccucccgu ucagcacgaa gaaccuggac      180

cuguccuuca acccccuccg ccaccugggg agcuacuccu ucuucagcuu ccccgagcug      240

cagguccucg accugucccg gugcgagauc cagaccaucg aggacggcgc cuaccagagc      300

cugucccacc ucagcacccu gauccugacc gggaacccca uccagucccu cgcccugggc      360

gccuucagcg ggcuguccag ccuccagaag cugguggcgg uggagacgaa ccuggccucc      420

cucgagaacu ucccgaucgg ccaccugaag acccugaagg agcucaacgu cgcccacaac      480

cugauccaga gcuucaagcu gcccgaguac uucuccaacc ucaccaaccu ggagcaccug      540

gaccucagca gcaacaagau ccaguccauc uacugcaccg accugcgcgu gcugcaccag      600

augccccucc ugaaccugag ccucgaccug ucccugaacc ccaugaacuu cauccagccg      660

ggcgccuuca aggagauccg gcuccacaag cugacgcugc gcaacaacuu cgacagccuc      720

aacgugauga agaccugcau ccaggggcug gcgggccugg agguccaccg gcucgugcug      780

ggggaguucc gcaacgaggg caaccuggag aaguucgaca aguccgcccu cgaggggcug      840

uacaaccuga ccaucgagga guuccggcug gccuaccucg acuacuaccu ggacgacauc      900

aucgaccugu ucaacugccu caccaacgug agcuccuuca gccuggucuc cgugacgauc      960

gagcgcguga aggacuucag cuacaacuuc ggcuggcagc accuggagcu cgucaacugc     1020

aaguucggcc aguuccccac ccugaagcug aagucccuca agcggcugac cuucaccagc     1080

aacaagggcg ggaacgccuu cuccgaggug gaccugccca gccucgaguu ccuggaccug     1140

ucccgcaacg ggcucagcuu caagggcugc ugcucccaga gcgacuucgg cacgaccucc     1200

cugaaguacc uggaccucag cuucaacggg gugaucacca ugagcuccaa cuuccugggc     1260

cuggagcagc ucgagcaccu ggacuuccag cacagcaacc ugaagcagau guccgaguuc     1320

agcgucuucc ucucccugcg gaaccugauc uaccucgaca ucagccacac ccacacgcgc     1380

guggccuuca acgggaucuu caacggccug uccagccugg aggugcucaa gauggcgggg     1440

aacuccuucc aggagaacuu ccugcccgac aucuucaccg agcugcggaa ccucaccuuc     1500

cuggaccuga gccagugcca gcucgagcag cuguccccga ccgccuucaa cagccugucc     1560

agccuccagg uccugaacau gucccacaac aacuucuuca gccuggacac guuccccuac     1620

aagugccuca acucccucca ggugcuggac uacagccuga accacaucau gaccagcaag     1680

aagcaggagc ugcagcacuu ccccuccagc cuggccuucc ucaaccugac ccagaacgac     1740

uucgccugca cgugcgagca ccaguccuuc cugcagugga ucaaggacca gcgccagcuc     1800

cugguggagg ucgagcggau ggagugcgcc acccccagcg acaagcaggg caugccggug     1860

cugucccuca acaucacgug ccagaugaac aagaccauca ucggcgucag cgugcugucc     1920

gugcuggucg ugagcguggu cgcggugcuc guguacaagu ucuacuucca ccugaugcug     1980

cucgccgggu gcaucaagua cggccgcggg gagaacaucu acgacgccuu cgucaucuac     2040

uccagccagg acgaggacug ggugcggaac gagcugguga agaaccugga ggagggcguc     2100

ccgcccuucc agcucugccu gcacuaccgc gacuucaucc ccgggguggc caucgccgcg     2160

aacaucaucc acgagggcuu ccacaagucc cggaagguga ucgucguggu gagccagcac     2220

uucauccagu cccgcuggug caucuucgag uacgagaucg cccagaccug gcaguuccug     2280

agcucccgcg ccggcaucau cuucaucguc cuccagaagg uggagaagac ccugcugcgg     2340

cagcaggucg agcucuaccg ccugcugagc cggaacaccu accucgagug ggaggacucc     2400

gugcuggggc gccacaucuu cuggcggcgc cugcggaagg cccuccugga cggcaagagc     2460

uggaaccccg aggggaccgu gggcaccggg ugcaacuggc aggaggccac guccaucuga     2520


<210>  9595
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR4__Homo_sapiens__AAY82270

<400>  9595
augauguccg ccucccgccu cgccggcacc cucauccccg ccauggccuu ccucuccugc       60

guccgccccg aguccuggga gcccugcguc gaggucgucc ccaacaucac cuaccagugc      120

auggagcuca acuucuacaa gauccccgac aaccuccccu ucuccaccaa gaaccucgac      180

cucuccuuca acccccuccg ccaccucggc uccuacuccu ucuucuccuu ccccgagcuc      240

cagguccucg accucucccg cugcgagauc cagaccaucg aggacggcgc cuaccagucc      300

cucucccacc ucuccacccu cauccucacc ggcaacccca uccagucccu cgcccucggc      360

gccuucuccg gccucuccuc ccuccagaag cucgucgccg ucgagaccaa ccucgccucc      420

cucgagaacu uccccaucgg ccaccucaag acccucaagg agcucaacgu cgcccacaac      480

cucauccagu ccuucaagcu ccccgaguac uucuccaacc ucaccaaccu cgagcaccuc      540

gaccucuccu ccaacaagau ccaguccauc uacugcaccg accuccgcgu ccuccaccag      600

augccccucc ucaaccucuc ccucgaccuc ucccucaacc ccaugaacuu cauccagccc      660

ggcgccuuca aggagauccg ccuccacaag cucacccucc gcaacaacuu cgacucccuc      720

aacgucauga agaccugcau ccagggccuc gccggccucg agguccaccg ccucguccuc      780

ggcgaguucc gcaacgaggg caaccucgag aaguucgaca aguccgcccu cgagggccuc      840

uacaaccuca ccaucgagga guuccgccuc gccuaccucg acuacuaccu cgacgacauc      900

aucgaccucu ucaacugccu caccaacguc uccuccuucu cccucgucuc cgucaccauc      960

gagcgcguca aggacuucuc cuacaacuuc ggcuggcagc accucgagcu cgucaacugc     1020

aaguucggcc aguuccccac ccucaagcuc aagucccuca agcgccucac cuucaccucc     1080

aacaagggcg gcaacgccuu cuccgagguc gaccuccccu cccucgaguu ccucgaccuc     1140

ucccgcaacg gccucuccuu caagggcugc ugcucccagu ccgacuucgg caccaccucc     1200

cucaaguacc ucgaccucuc cuucaacggc gucaucacca uguccuccaa cuuccucggc     1260

cucgagcagc ucgagcaccu cgacuuccag cacuccaacc ucaagcagau guccgaguuc     1320

uccgucuucc ucucccuccg caaccucauc uaccucgaca ucucccacac ccacacccgc     1380

gucgccuuca acggcaucuu caacggccuc uccucccucg agguccucaa gauggccggc     1440

aacuccuucc aggagaacuu ccuccccgac aucuucaccg agcuccgcaa ccucaccuuc     1500

cucgaccucu cccagugcca gcucgagcag cucuccccca ccgccuucaa cucccucucc     1560

ucccuccagg uccucaacau gucccacaac aacuucuucu cccucgacac cuuccccuac     1620

aagugccuca acucccucca gguccucgac uacucccuca accacaucau gaccuccaag     1680

aagcaggagc uccagcacuu ccccuccucc cucgccuucc ucaaccucac ccagaacgac     1740

uucgccugca ccugcgagca ccaguccuuc cuccagugga ucaaggacca gcgccagcuc     1800

cucgucgagg ucgagcgcau ggagugcgcc acccccuccg acaagcaggg caugcccguc     1860

cucucccuca acaucaccug ccagaugaac aagaccauca ucggcgucuc cguccucucc     1920

guccucgucg ucuccgucgu cgccguccuc gucuacaagu ucuacuucca ccucaugcuc     1980

cucgccggcu gcaucaagua cggccgcggc gagaacaucu acgacgccuu cgucaucuac     2040

uccucccagg acgaggacug gguccgcaac gagcucguca agaaccucga ggagggcguc     2100

ccccccuucc agcucugccu ccacuaccgc gacuucaucc ccggcgucgc caucgccgcc     2160

aacaucaucc acgagggcuu ccacaagucc cgcaagguca ucgucgucgu cucccagcac     2220

uucauccagu cccgcuggug caucuucgag uacgagaucg cccagaccug gcaguuccuc     2280

uccucccgcg ccggcaucau cuucaucguc cuccagaagg ucgagaagac ccuccuccgc     2340

cagcaggucg agcucuaccg ccuccucucc cgcaacaccu accucgagug ggaggacucc     2400

guccucggcc gccacaucuu cuggcgccgc cuccgcaagg cccuccucga cggcaagucc     2460

uggaaccccg agggcaccgu cggcaccggc ugcaacuggc aggaggccac cuccaucuga     2520


<210>  9596
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR4__Homo_sapiens__AAY82270

<400>  9596
augaugagcg ccuccagacu ggcuggcacc cucauccccg caauggccuu ccuuucuugc       60

gugaggccug agucauggga accauguguc gagguugugc cgaacauuac auaccagugc      120

auggaacuga auuuuuauaa gauacccgac aacuugccuu ucaguacuaa aaauuuagau      180

cugagcuuua acccacuacg gcaccucggg uccuacucuu ucuuuucguu ccccgagcug      240

caaguacuug accugucacg cugugaaauc cagacgauug aggauggagc guaucagagc      300

uugagucauc ucuccacccu gauccugaca gguaauccua uucagucucu cgcuuuaggc      360

gccuuuagcg ggcuguccuc acuucaaaag uugguggcag ucgagacuaa ccuggccagu      420

cuagaaaauu ucccaaucgg acaccucaaa acccugaagg agcuuaacgu ggcucauaau      480

cugauacaga gcuuuaaauu gcccgaauac uucucuaacc ucacaaaucu ggagcacuua      540

gaccuguccu caaacaagau ccagagcauu uauugcaccg aucuccgagu ucuucaucag      600

augccucugu ugaaucuaag ucuggaccuc ucucugaacc caaugaauuu uauccaaccg      660

ggcgcauuca aggagauucg ucuucacaaa cugacuuuga gaaacaacuu ugauucccuc      720

aaugugauga agacauguau ccagggucug gccggguuag aaguccacag gcuggugcua      780

ggagaguucc ggaacgaagg caaucucgag aaauucgaca agagcgcucu ggaaggccuu      840

uacaacuuga ccauagagga guuucgccug gccuaucucg auuacuaccu ggacgauauu      900

aucgaccuuu ucaauugccu gacgaacgua ucgucuuuuu ccuugguuuc agugacuauu      960

gaaagaguca aagauuucag uuauaauuuu ggguggcagc aucucgagcu ggugaacugu     1020

aaguucggac aguuucccac cuuaaagcug aaaagccuaa agaggcucac auucacuucc     1080

aauaaaggug gcaacgcguu uucugaagug gaccugccua gccuugaguu cuuggaccug     1140

ucacggaaug ggcucaguuu uaagggaugc uguucccaaa gcgauuucgg caccacaucu     1200

cugaaauacu uagaccuguc auuuaacggu gucaucacca ugaguagcaa uuuccuuggg     1260

uuggaacagc ucgagcaccu ggauuuccag cauuccaacc uaaagcaaau gucugaguuu     1320

ucgguuuucc ugagccuccg caaucugauc uaucuugaca uuucccacac gcacacucga     1380

guggcauuua acggaauauu caacggcuug ucaagucugg aaguauuaaa aauggccggc     1440

aauucuuuuc aggagaacuu ccucccagau aucuuuacag aacugagaaa ucuuaccuuc     1500

cuggacuuga gccagugcca gcucgagcaa cuguccccca cugcuuuuaa cucacuaagc     1560

ucucuccagg ugcugaauau gucccauaac aauuucuuua gucuggauac auucccuuac     1620

aagugucuua acagcuugca gguccuggac uauucuuuaa aucacauuau gaccuccaag     1680

aaacaggaac uccaacauuu uccaucaagu cuggccuucc uuaaccugac gcagaaugau     1740

uucgcaugua ccugcgagca ccagagcuuu cuacagugga ucaaggacca aaggcagcuc     1800

cugguggagg uugaacggau ggagugcgcu acacccucgg auaaacaggg gaugccggug     1860

uugucccuga acauaacuug ccagaugaau aagaccauua ucggagucuc uguguuaagc     1920

guacucguug ugucagucgu ggccguccug guguacaaau ucuauuuuca ucuuaugcug     1980

uuggcggguu guaucaagua cggccguggg gaaaacauuu acgacgccuu cguuaucuau     2040

aguucccaag acgaggauug ggugcgcaau gagcucguaa agaaccugga agagggaguc     2100

ccucccuuuc agcuaugccu gcacuacaga gacuucauuc caggcguggc aauagcugcc     2160

aacaucauuc acgaagguuu ucauaaaucu aggaagguua ucguggucgu gagccagcac     2220

uucauccaau cccgguggug uauuuuugag uaugaaauag cucagacaug gcaguuccuu     2280

ucaagccgag ccgggaucau uuuuaucgua cuccagaaag uggagaagac ucuguugcgc     2340

caacagguug agcuguacag auuacucagu aggaauaccu aucuggaaug ggaggauucu     2400

guccuuggcc ggcauauuuu cuggcgcaga cugaggaaag cauugcucga cggaaagucc     2460

uggaacccug aaggcacagu ggggaccgga ugcaauuggc aggaggccac uagcaucuga     2520


<210>  9597
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR4__Homo_sapiens__AAY82270

<400>  9597
augaugagcg ccagcagacu ggccggcacc cugauccccg ccauggccuu ccugagcugc       60

gugagacccg agagcuggga gcccugcgug gagguggugc ccaacaucac cuaccagugc      120

auggagcuga acuucuacaa gauccccgac aaccugcccu ucagcaccaa gaaccuggac      180

cugagcuuca acccccugag acaccugggc agcuacagcu ucuucagcuu ccccgagcug      240

caggugcugg accugagcag augcgagauc cagaccaucg aggacggcgc cuaccagagc      300

cugagccacc ugagcacccu gauccugacc ggcaacccca uccagagccu ggcccugggc      360

gccuucagcg gccugagcag ccugcagaag cugguggccg uggagaccaa ccuggccagc      420

cuggagaacu uccccaucgg ccaccugaag acccugaagg agcugaacgu ggcccacaac      480

cugauccaga gcuucaagcu gcccgaguac uucagcaacc ugaccaaccu ggagcaccug      540

gaccugagca gcaacaagau ccagagcauc uacugcaccg accugagagu gcugcaccag      600

augccccugc ugaaccugag ccuggaccug agccugaacc ccaugaacuu cauccagccc      660

ggcgccuuca aggagaucag acugcacaag cugacccuga gaaacaacuu cgacagccug      720

aacgugauga agaccugcau ccagggccug gccggccugg aggugcacag acuggugcug      780

ggcgaguuca gaaacgaggg caaccuggag aaguucgaca agagcgcccu ggagggccug      840

uacaaccuga ccaucgagga guucagacug gccuaccugg acuacuaccu ggacgacauc      900

aucgaccugu ucaacugccu gaccaacgug agcagcuuca gccuggugag cgugaccauc      960

gagagaguga aggacuucag cuacaacuuc ggcuggcagc accuggagcu ggugaacugc     1020

aaguucggcc aguuccccac ccugaagcug aagagccuga agagacugac cuucaccagc     1080

aacaagggcg gcaacgccuu cagcgaggug gaccugccca gccuggaguu ccuggaccug     1140

agcagaaacg gccugagcuu caagggcugc ugcagccaga gcgacuucgg caccaccagc     1200

cugaaguacc uggaccugag cuucaacggc gugaucacca ugagcagcaa cuuccugggc     1260

cuggagcagc uggagcaccu ggacuuccag cacagcaacc ugaagcagau gagcgaguuc     1320

agcguguucc ugagccugag aaaccugauc uaccuggaca ucagccacac ccacaccaga     1380

guggccuuca acggcaucuu caacggccug agcagccugg aggugcugaa gauggccggc     1440

aacagcuucc aggagaacuu ccugcccgac aucuucaccg agcugagaaa ccugaccuuc     1500

cuggaccuga gccagugcca gcuggagcag cugagcccca ccgccuucaa cagccugagc     1560

agccugcagg ugcugaacau gagccacaac aacuucuuca gccuggacac cuuccccuac     1620

aagugccuga acagccugca ggugcuggac uacagccuga accacaucau gaccagcaag     1680

aagcaggagc ugcagcacuu ccccagcagc cuggccuucc ugaaccugac ccagaacgac     1740

uucgccugca ccugcgagca ccagagcuuc cugcagugga ucaaggacca gagacagcug     1800

cugguggagg uggagagaau ggagugcgcc acccccagcg acaagcaggg caugcccgug     1860

cugagccuga acaucaccug ccagaugaac aagaccauca ucggcgugag cgugcugagc     1920

gugcuggugg ugagcguggu ggccgugcug guguacaagu ucuacuucca ccugaugcug     1980

cuggccggcu gcaucaagua cggcagaggc gagaacaucu acgacgccuu cgugaucuac     2040

agcagccagg acgaggacug ggugagaaac gagcugguga agaaccugga ggagggcgug     2100

ccccccuucc agcugugccu gcacuacaga gacuucaucc ccggcguggc caucgccgcc     2160

aacaucaucc acgagggcuu ccacaagagc agaaagguga ucgugguggu gagccagcac     2220

uucauccaga gcagauggug caucuucgag uacgagaucg cccagaccug gcaguuccug     2280

agcagcagag ccggcaucau cuucaucgug cugcagaagg uggagaagac ccugcugaga     2340

cagcaggugg agcuguacag acugcugagc agaaacaccu accuggagug ggaggacagc     2400

gugcugggca gacacaucuu cuggagaaga cugagaaagg cccugcugga cggcaagagc     2460

uggaaccccg agggcaccgu gggcaccggc ugcaacuggc aggaggccac cagcaucuga     2520


<210>  9598
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR4__Homo_sapiens__AAY82270

<400>  9598
augaugagcg ccuccagacu ggcuggcacc cucauccccg ccauggcguu ccugucuugc       60

gugcggccug agagcuggga accguguguc gagguugugc ccaacauuac auaccagugc      120

auggaacuua auuuuuauaa gaucccugac aaccugcccu ucuccacgaa aaaucucgau      180

cugucuuuua acccucuucg ccaccugggg agcuacuccu ucuuuucuuu ccccgagcuc      240

caagugcugg accugagcag augugaaauu cagaccaucg aggauggagc uuaucagucc      300

cucagccauc ugucuacacu uauucugacc ggcaauccua uccagucccu cgcccugggg      360

gccuuuagcg gacuuucuuc ccugcaaaag cucgucgcug uggagacaaa ccuggccagc      420

cuggaaaauu ucccgaucgg ccaccucaaa acccugaagg agcuuaacgu ugcucauaau      480

cugauucagu cuuuuaaacu ccccgaauac uucuccaacc ugacaaaucu ugagcaccug      540

gaccucagcu ccaacaagau ccagucuauu uauugcaccg aucugcgggu gcugcaucag      600

augccucucc ugaaucuuag ccuggaccuc ucccugaacc ccaugaauuu uauccaaccu      660

ggggccuuca aggagauucg ccuucacaaa cugacgcuca gaaacaacuu ugauagccug      720

aaugucauga agaccuguau ccagggacug gcgggccucg aagugcaccg gcugguucuu      780

ggcgaguucc gcaacgaagg gaaucuggag aaauucgaca agucugcccu cgaaggacug      840

uacaaccuga caauugagga guuuagacuu gcuuaucucg auuacuaccu ggacgauauc      900

aucgaccugu ucaauugccu caccaacgug uccagcuuuu cucuggucag cgugacaauu      960

gaacggguga aagauuucuc cuauaauuuu ggcuggcagc aucuugagcu ggucaacugu     1020

aaguucgggc aguuucccac ccucaagcug aaaucucuga agcgccuuac guucacaagc     1080

aauaaaggag gcaacgccuu uuccgaaguu gaccucccga gccuggaguu ccuggaccuc     1140

ucuagaaaug ggcuguccuu uaagggaugc uguagccaau cugauuucgg caccacaucc     1200

cuuaaauacc uggaccucag cuuuaacggc gugaucacca uguccucuaa uuuccugggg     1260

cuggaacagc uugagcaccu cgauuuccag cauagcaacc ugaagcaaau guccgaguuu     1320

ucuguguucc ugagccuccg gaaucugauu uaucuugaca ucucccacac ccacacacgc     1380

gucgcuuuua acggaauuuu caacggccug agcucucucg aagugcugaa aauggccgga     1440

aauuccuuuc aggagaacuu ccugccugau aucuuuacgg aacuuagaaa ucucaccuuc     1500

cuggaccuga gccagugcca gcucgagcaa cugucuccca cagcguuuaa cucccuuagc     1560

ucucugcagg uucucaauau gagccauaac aauuucuuuu cccuggauac cuucccuuac     1620

aagugucuga acagccuuca ggugcuggac uauucucuca aucacaucau gacauccaag     1680

aaacaggaac ugcaacauuu ucccagcucc cucgccuucc ugaaccuuac ccagaaugau     1740

uucgcuugca cgugcgagca ccagucuuuu cugcagugga uuaaggacca acggcagcuc     1800

cuggucgagg uggaacgcau ggagugugcc acacccagcg auaaacaggg gaugccuguu     1860

cugucccuua acauuaccug ccagaugaau aagaccauca ucggcguguc uguccugagc     1920

gugcucgucg uguccguugu ggcuguccug guguacaaau ucuauuuuca ucucaugcug     1980

cuugccgggu guauuaagua cggaagaggc gaaaacaucu acgacgccuu cguuaucuau     2040

ucuagccaag acgaggauug ggugcggaau gagcugguca agaaccucga agagggcgug     2100

ccgcccuuuc agcugugccu gcacuacaga gacuucauuc cugggguggc uaucgcggcc     2160

aacauuaucc acgaaggauu ucauaaaucc cgcaagguua uugucguggu gagccagcac     2220

uucauccaau cucgguggug uauuuuugag uaugaaaucg cucagacaug gcaguuccuu     2280

uccagcagag ccggcaucau uuuuaucguc cugcagaaag uggagaagac ccuccugcgc     2340

caacagguug agcucuaccg gcugcuuucu agaaauacau aucuggaaug ggaggauucc     2400

gugcuggggc gccauauuuu cuggcggaga cuccgcaaag cccugcuuga cggaaagagc     2460

uggaaccccg aaggcacggu cgggaccggc ugcaauuggc aggaggcuac aucuaucuga     2520


<210>  9599
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR4__Homo_sapiens__O00206

<400>  9599

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  9600
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR4__Homo_sapiens__AAC80227

<400>  9600
augaugucug ccucgcgccu ggcugggacu cugaucccag ccauggccuu ccucuccugc       60

gugagaccag aaagcuggga gcccugcgug gaggugguuc cuaauauuac uuaucaaugc      120

auggagcuga auuucuacaa aauccccgac aaccuccccu ucucaaccaa gaaccuggac      180

cugagcuuua auccccugag gcauuuaggc agcuauagcu ucuucaguuu cccagaacug      240

caggugcugg auuuauccag gugugaaauc cagacaauug aagauggggc auaucagagc      300

cuaagccacc ucucuaccuu aauauugaca ggaaacccca uccagaguuu agcccuggga      360

gccuuuucug gacuaucaag uuuacagaag cugguggcug uggagacaaa ucuagcaucu      420

cuagagaacu uccccauugg acaucucaaa acuuugaaag aacuuaaugu ggcucacaau      480

cuuauccaau cuuucaaauu accugaguau uuuucuaauc ugaccaaucu agagcacuug      540

gaccuuucca gcaacaagau ucaaaguauu uauugcacag acuugcgggu ucuacaucaa      600

augccccuac ucaaucucuc uuuagaccug ucccugaauc cuaugaacuu uauccaacca      660

ggugcauuua aagaaauuag gcuucauaag cugacuuuaa gaaauaauuu ugauaguuua      720

aauguaauga aaacuuguau ucaaggucug gcugguuuag aaguccaucg uuugguucug      780

ggagaauuua gaaaugaagg aaacuuggaa aaguuugaca aaucugcucu agagggccug      840

ugcaauuuga ccauugaaga auuccgauua gcauacuuag acuacuaccu cgaugauauu      900

auugacuuau uuaauuguuu gacaaauguu ucuucauuuu cccuggugag ugugacuauu      960

gaaaggguaa aagacuuuuc uuauaauuuc ggauggcaac auuuagaauu aguuaacugu     1020

aaauuuggac aguuucccac auugaaacuc aaaucucuca aaaggcuuac uuucacuucc     1080

aacaaaggug ggaaugcuuu uucagaaguu gaucuaccaa gccuugaguu ucuagaucuc     1140

aguagaaaug gcuugaguuu caaagguugc uguucucaaa gugauuuugg gacaaccagc     1200

cuaaaguauu uagaucugag cuucaauggu guuauuacca ugaguucaaa cuucuugggc     1260

uuagaacaac uagaacaucu ggauuuccag cauuccaauu ugaaacaaau gagugaguuu     1320

ucaguauucc uaucacucag aaaccucauu uaccuugaca uuucucauac ucacaccaga     1380

guugcuuuca auggcaucuu caauggcuug uccagucucg aagucuugaa aauggcuggc     1440

aauucuuucc aggaaaacuu ccuuccagau aucuucacag agcugagaaa cuugaccuuc     1500

cuggaccucu cucaguguca acuggagcag uugucuccaa cagcauuuaa cucacucucc     1560

agucuucagg uacuaaauau gagccacaac aacuucuuuu cauuggauac guuuccuuau     1620

aagugucuga acucccucca gguucuugau uacagucuca aucacauaau gacuuccaaa     1680

aaacaggaac uacagcauuu uccaaguagu cuagcuuucu uaaaucuuac ucagaaugac     1740

uuugcuugua cuugugaaca ccagaguuuc cugcaaugga ucaaggacca gaggcagcuc     1800

uugguggaag uugaacgaau ggaaugugca acaccuucag auaagcaggg caugccugug     1860

cugaguuuga auaucaccug ucagaugaau aagaccauca uugguguguc gguccucagu     1920

gugcuuguag uaucuguugu agcaguucug gucuauaagu ucuauuuuca ccugaugcuu     1980

cuugcuggcu gcauaaagua ugguagaggu gaaaacaucu augaugccuu uguuaucuac     2040

ucaagccagg augaggacug gguaaggaau gagcuaguaa agaauuuaga agaaggggug     2100

ccuccauuuc agcucugccu ucacuacaga gacuuuauuc ccgguguggc cauugcugcc     2160

aacaucaucc augaagguuu ccauaaaagc cgaaagguga uuguuguggu gucccagcac     2220

uucauccaga gccgcuggug uaucuuugaa uaugagauug cucagaccug gcaguuucug     2280

agcagucgug cugguaucau cuucauuguc cugcagaagg uggagaagac ccugcucagg     2340

cagcaggugg agcuguaccg ccuucucagc aggaacacuu accuggagug ggaggacagu     2400

guccuggggc ggcacaucuu cuggagacga cucagaaaag cccugcugga ugguaaauca     2460

uggaauccag aaggaacagu ggguacagga ugcaauuggc aggaagcaac aucuaucuga     2520


<210>  9601
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR4__Homo_sapiens__AAC80227

<400>  9601
augaugagcg ccucccgccu ggccggcacc cucauccccg cgauggccuu ccugagcugc       60

gugcggccgg aguccuggga gcccugcguc gagguggugc ccaacaucac cuaccagugc      120

auggagcuga acuucuacaa gauccccgac aaccucccgu ucagcacgaa gaaccuggac      180

cuguccuuca acccccuccg ccaccugggg agcuacuccu ucuucagcuu ccccgagcug      240

cagguccucg accugucccg gugcgagauc cagaccaucg aggacggcgc cuaccagagc      300

cugucccacc ucagcacccu gauccugacc gggaacccca uccagucccu cgcccugggc      360

gccuucagcg ggcuguccag ccuccagaag cugguggcgg uggagacgaa ccuggccucc      420

cucgagaacu ucccgaucgg ccaccugaag acccugaagg agcucaacgu cgcccacaac      480

cugauccaga gcuucaagcu gcccgaguac uucuccaacc ucaccaaccu ggagcaccug      540

gaccucagca gcaacaagau ccaguccauc uacugcaccg accugcgcgu gcugcaccag      600

augccccucc ugaaccugag ccucgaccug ucccugaacc ccaugaacuu cauccagccg      660

ggcgccuuca aggagauccg gcuccacaag cugacgcugc gcaacaacuu cgacagccuc      720

aacgugauga agaccugcau ccaggggcug gcgggccugg agguccaccg gcucgugcug      780

ggggaguucc gcaacgaggg caaccuggag aaguucgaca aguccgcccu cgaggggcug      840

ugcaaccuga ccaucgagga guuccggcug gccuaccucg acuacuaccu ggacgacauc      900

aucgaccugu ucaacugccu caccaacgug agcuccuuca gccuggucuc cgugacgauc      960

gagcgcguga aggacuucag cuacaacuuc ggcuggcagc accuggagcu cgucaacugc     1020

aaguucggcc aguuccccac ccugaagcug aagucccuca agcggcugac cuucaccagc     1080

aacaagggcg ggaacgccuu cuccgaggug gaccugccca gccucgaguu ccuggaccug     1140

ucccgcaacg ggcucagcuu caagggcugc ugcucccaga gcgacuucgg cacgaccucc     1200

cugaaguacc uggaccucag cuucaacggg gugaucacca ugagcuccaa cuuccugggc     1260

cuggagcagc ucgagcaccu ggacuuccag cacagcaacc ugaagcagau guccgaguuc     1320

agcgucuucc ucucccugcg gaaccugauc uaccucgaca ucagccacac ccacacgcgc     1380

guggccuuca acgggaucuu caacggccug uccagccugg aggugcucaa gauggcgggg     1440

aacuccuucc aggagaacuu ccugcccgac aucuucaccg agcugcggaa ccucaccuuc     1500

cuggaccuga gccagugcca gcucgagcag cuguccccga ccgccuucaa cagccugucc     1560

agccuccagg uccugaacau gucccacaac aacuucuuca gccuggacac guuccccuac     1620

aagugccuca acucccucca ggugcuggac uacagccuga accacaucau gaccagcaag     1680

aagcaggagc ugcagcacuu ccccuccagc cuggccuucc ucaaccugac ccagaacgac     1740

uucgccugca cgugcgagca ccaguccuuc cugcagugga ucaaggacca gcgccagcuc     1800

cugguggagg ucgagcggau ggagugcgcc acccccagcg acaagcaggg caugccggug     1860

cugucccuca acaucacgug ccagaugaac aagaccauca ucggcgucag cgugcugucc     1920

gugcuggucg ugagcguggu cgcggugcuc guguacaagu ucuacuucca ccugaugcug     1980

cucgccgggu gcaucaagua cggccgcggg gagaacaucu acgacgccuu cgucaucuac     2040

uccagccagg acgaggacug ggugcggaac gagcugguga agaaccugga ggagggcguc     2100

ccgcccuucc agcucugccu gcacuaccgc gacuucaucc ccgggguggc caucgccgcg     2160

aacaucaucc acgagggcuu ccacaagucc cggaagguga ucgucguggu gagccagcac     2220

uucauccagu cccgcuggug caucuucgag uacgagaucg cccagaccug gcaguuccug     2280

agcucccgcg ccggcaucau cuucaucguc cuccagaagg uggagaagac ccugcugcgg     2340

cagcaggucg agcucuaccg ccugcugagc cggaacaccu accucgagug ggaggacucc     2400

gugcuggggc gccacaucuu cuggcggcgc cugcggaagg cccuccugga cggcaagagc     2460

uggaaccccg aggggaccgu gggcaccggg ugcaacuggc aggaggccac guccaucuga     2520


<210>  9602
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR4__Homo_sapiens__AAC80227

<400>  9602
augauguccg ccucccgccu cgccggcacc cucauccccg ccauggccuu ccucuccugc       60

guccgccccg aguccuggga gcccugcguc gaggucgucc ccaacaucac cuaccagugc      120

auggagcuca acuucuacaa gauccccgac aaccuccccu ucuccaccaa gaaccucgac      180

cucuccuuca acccccuccg ccaccucggc uccuacuccu ucuucuccuu ccccgagcuc      240

cagguccucg accucucccg cugcgagauc cagaccaucg aggacggcgc cuaccagucc      300

cucucccacc ucuccacccu cauccucacc ggcaacccca uccagucccu cgcccucggc      360

gccuucuccg gccucuccuc ccuccagaag cucgucgccg ucgagaccaa ccucgccucc      420

cucgagaacu uccccaucgg ccaccucaag acccucaagg agcucaacgu cgcccacaac      480

cucauccagu ccuucaagcu ccccgaguac uucuccaacc ucaccaaccu cgagcaccuc      540

gaccucuccu ccaacaagau ccaguccauc uacugcaccg accuccgcgu ccuccaccag      600

augccccucc ucaaccucuc ccucgaccuc ucccucaacc ccaugaacuu cauccagccc      660

ggcgccuuca aggagauccg ccuccacaag cucacccucc gcaacaacuu cgacucccuc      720

aacgucauga agaccugcau ccagggccuc gccggccucg agguccaccg ccucguccuc      780

ggcgaguucc gcaacgaggg caaccucgag aaguucgaca aguccgcccu cgagggccuc      840

ugcaaccuca ccaucgagga guuccgccuc gccuaccucg acuacuaccu cgacgacauc      900

aucgaccucu ucaacugccu caccaacguc uccuccuucu cccucgucuc cgucaccauc      960

gagcgcguca aggacuucuc cuacaacuuc ggcuggcagc accucgagcu cgucaacugc     1020

aaguucggcc aguuccccac ccucaagcuc aagucccuca agcgccucac cuucaccucc     1080

aacaagggcg gcaacgccuu cuccgagguc gaccuccccu cccucgaguu ccucgaccuc     1140

ucccgcaacg gccucuccuu caagggcugc ugcucccagu ccgacuucgg caccaccucc     1200

cucaaguacc ucgaccucuc cuucaacggc gucaucacca uguccuccaa cuuccucggc     1260

cucgagcagc ucgagcaccu cgacuuccag cacuccaacc ucaagcagau guccgaguuc     1320

uccgucuucc ucucccuccg caaccucauc uaccucgaca ucucccacac ccacacccgc     1380

gucgccuuca acggcaucuu caacggccuc uccucccucg agguccucaa gauggccggc     1440

aacuccuucc aggagaacuu ccuccccgac aucuucaccg agcuccgcaa ccucaccuuc     1500

cucgaccucu cccagugcca gcucgagcag cucuccccca ccgccuucaa cucccucucc     1560

ucccuccagg uccucaacau gucccacaac aacuucuucu cccucgacac cuuccccuac     1620

aagugccuca acucccucca gguccucgac uacucccuca accacaucau gaccuccaag     1680

aagcaggagc uccagcacuu ccccuccucc cucgccuucc ucaaccucac ccagaacgac     1740

uucgccugca ccugcgagca ccaguccuuc cuccagugga ucaaggacca gcgccagcuc     1800

cucgucgagg ucgagcgcau ggagugcgcc acccccuccg acaagcaggg caugcccguc     1860

cucucccuca acaucaccug ccagaugaac aagaccauca ucggcgucuc cguccucucc     1920

guccucgucg ucuccgucgu cgccguccuc gucuacaagu ucuacuucca ccucaugcuc     1980

cucgccggcu gcaucaagua cggccgcggc gagaacaucu acgacgccuu cgucaucuac     2040

uccucccagg acgaggacug gguccgcaac gagcucguca agaaccucga ggagggcguc     2100

ccccccuucc agcucugccu ccacuaccgc gacuucaucc ccggcgucgc caucgccgcc     2160

aacaucaucc acgagggcuu ccacaagucc cgcaagguca ucgucgucgu cucccagcac     2220

uucauccagu cccgcuggug caucuucgag uacgagaucg cccagaccug gcaguuccuc     2280

uccucccgcg ccggcaucau cuucaucguc cuccagaagg ucgagaagac ccuccuccgc     2340

cagcaggucg agcucuaccg ccuccucucc cgcaacaccu accucgagug ggaggacucc     2400

guccucggcc gccacaucuu cuggcgccgc cuccgcaagg cccuccucga cggcaagucc     2460

uggaaccccg agggcaccgu cggcaccggc ugcaacuggc aggaggccac cuccaucuga     2520


<210>  9603
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR4__Homo_sapiens__AAC80227

<400>  9603
augaugagcg ccuccagacu ggcuggcacc cucauccccg caauggccuu ccuuucuugc       60

gugaggccug agucauggga accauguguc gagguugugc cgaacauuac auaccagugc      120

auggaacuga auuuuuauaa gauacccgac aacuugccuu ucaguacuaa aaauuuagau      180

cugagcuuua acccacuacg gcaccucggg uccuacucuu ucuuuucguu ccccgagcug      240

caaguacuug accugucacg cugugaaauc cagacgauug aggauggagc guaucagagc      300

uugagucauc ucuccacccu gauccugaca gguaauccua uucagucucu cgcuuuaggc      360

gccuuuagcg ggcuguccuc acuucaaaag uugguggcag ucgagacuaa ccuggccagu      420

cuagaaaauu ucccaaucgg acaccucaaa acccugaagg agcuuaacgu ggcucauaau      480

cugauacaga gcuuuaaauu gcccgaauac uucucuaacc ucacaaaucu ggagcacuua      540

gaccuguccu caaacaagau ccagagcauu uauugcaccg aucuccgagu ucuucaucag      600

augccucugu ugaaucuaag ucuggaccuc ucucugaacc caaugaauuu uauccaaccg      660

ggcgcauuca aggagauucg ucuucacaaa cugacuuuga gaaacaacuu ugauucccuc      720

aaugugauga agacauguau ccagggucug gccggguuag aaguccacag gcuggugcua      780

ggagaguucc ggaacgaagg caaucucgag aaauucgaca agagcgcucu ggaaggccuu      840

ugcaacuuga ccauagagga guuucgccug gccuaccucg auuauuaccu ggacgauauu      900

aucgaccuuu ucaauugucu gacgaacgua ucgucuuuuu ccuugguuuc agugacuauu      960

gaaagaguca aagauuucag uuacaauuuu ggguggcagc aucucgagcu ggugaacugc     1020

aaguucggac aguuucccac cuuaaagcug aaaagccuaa agaggcucac auucacuucc     1080

aauaaaggug gcaacgcguu uucugaagug gaccugccua gccuugaguu cuuggaccug     1140

ucacggaaug ggcucaguuu uaagggaugu ugcucccaaa gcgauuucgg caccacaucu     1200

cugaaauauu uagaccuguc auuuaacggu gucaucacca ugaguagcaa uuuccuuggg     1260

uuggaacagc ucgagcaccu ggauuuccag cauuccaacc uaaagcaaau gucugaguuu     1320

ucgguuuucc ugagccuccg caaucugauc uaccuugaca uuucccacac gcacacucga     1380

guggcauuua acggaauauu caacggcuug ucaagucugg aaguauuaaa aauggccggc     1440

aauucuuuuc aggagaacuu ccucccagau aucuuuacag aacugagaaa ucuuaccuuc     1500

cuggacuuga gccaguguca gcucgagcaa cuguccccca cugcuuuuaa cucacuaagc     1560

ucucuccagg ugcugaauau gucccauaac aauuucuuua gucuggauac auucccuuau     1620

aagugccuua acagcuugca gguccuggac uacucuuuaa aucacauuau gaccuccaag     1680

aaacaggaac uccaacauuu uccaucaagu cuggccuucc uuaaccugac gcagaaugau     1740

uucgcaugca ccugugagca ccagagcuuu cuacagugga ucaaggacca aaggcagcuc     1800

cugguggagg uugaacggau ggagugcgcu acacccucgg auaaacaggg gaugccggug     1860

uugucccuga acauaacuug ucagaugaau aagaccauua ucggagucuc uguguuaagc     1920

guacucguug ugucagucgu ggccguccug guguauaaau ucuacuuuca ucuuaugcug     1980

uuggcggguu gcaucaagua uggccguggg gaaaacauuu acgacgccuu cguuaucuac     2040

aguucccaag acgaggauug ggugcgcaau gagcucguaa agaaccugga agagggaguc     2100

ccucccuuuc agcuaugucu gcacuauaga gacuucauuc caggcguggc aauagcugcc     2160

aacaucauuc acgaagguuu ucauaaaucu aggaagguua ucguggucgu gagccagcac     2220

uucauccaau cccgguggug cauuuuugag uacgaaauag cucagacaug gcaguuccuu     2280

ucaagccgag ccgggaucau uuuuaucgua cuccagaaag uggagaagac ucuguugcgc     2340

caacagguug agcuguauag auuacucagu aggaauaccu accuggaaug ggaggauucu     2400

guccuuggcc ggcauauuuu cuggcgcaga cugaggaaag cauugcucga cggaaagucc     2460

uggaacccug aaggcacagu ggggaccgga uguaauuggc aggaggccac uagcaucuga     2520


<210>  9604
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR4__Homo_sapiens__AAC80227

<400>  9604
augaugagcg ccagcagacu ggccggcacc cugauccccg ccauggccuu ccugagcugc       60

gugagacccg agagcuggga gcccugcgug gagguggugc ccaacaucac cuaccagugc      120

auggagcuga acuucuacaa gauccccgac aaccugcccu ucagcaccaa gaaccuggac      180

cugagcuuca acccccugag acaccugggc agcuacagcu ucuucagcuu ccccgagcug      240

caggugcugg accugagcag augcgagauc cagaccaucg aggacggcgc cuaccagagc      300

cugagccacc ugagcacccu gauccugacc ggcaacccca uccagagccu ggcccugggc      360

gccuucagcg gccugagcag ccugcagaag cugguggccg uggagaccaa ccuggccagc      420

cuggagaacu uccccaucgg ccaccugaag acccugaagg agcugaacgu ggcccacaac      480

cugauccaga gcuucaagcu gcccgaguac uucagcaacc ugaccaaccu ggagcaccug      540

gaccugagca gcaacaagau ccagagcauc uacugcaccg accugagagu gcugcaccag      600

augccccugc ugaaccugag ccuggaccug agccugaacc ccaugaacuu cauccagccc      660

ggcgccuuca aggagaucag acugcacaag cugacccuga gaaacaacuu cgacagccug      720

aacgugauga agaccugcau ccagggccug gccggccugg aggugcacag acuggugcug      780

ggcgaguuca gaaacgaggg caaccuggag aaguucgaca agagcgcccu ggagggccug      840

ugcaaccuga ccaucgagga guucagacug gccuaccugg acuacuaccu ggacgacauc      900

aucgaccugu ucaacugccu gaccaacgug agcagcuuca gccuggugag cgugaccauc      960

gagagaguga aggacuucag cuacaacuuc ggcuggcagc accuggagcu ggugaacugc     1020

aaguucggcc aguuccccac ccugaagcug aagagccuga agagacugac cuucaccagc     1080

aacaagggcg gcaacgccuu cagcgaggug gaccugccca gccuggaguu ccuggaccug     1140

agcagaaacg gccugagcuu caagggcugc ugcagccaga gcgacuucgg caccaccagc     1200

cugaaguacc uggaccugag cuucaacggc gugaucacca ugagcagcaa cuuccugggc     1260

cuggagcagc uggagcaccu ggacuuccag cacagcaacc ugaagcagau gagcgaguuc     1320

agcguguucc ugagccugag aaaccugauc uaccuggaca ucagccacac ccacaccaga     1380

guggccuuca acggcaucuu caacggccug agcagccugg aggugcugaa gauggccggc     1440

aacagcuucc aggagaacuu ccugcccgac aucuucaccg agcugagaaa ccugaccuuc     1500

cuggaccuga gccagugcca gcuggagcag cugagcccca ccgccuucaa cagccugagc     1560

agccugcagg ugcugaacau gagccacaac aacuucuuca gccuggacac cuuccccuac     1620

aagugccuga acagccugca ggugcuggac uacagccuga accacaucau gaccagcaag     1680

aagcaggagc ugcagcacuu ccccagcagc cuggccuucc ugaaccugac ccagaacgac     1740

uucgccugca ccugcgagca ccagagcuuc cugcagugga ucaaggacca gagacagcug     1800

cugguggagg uggagagaau ggagugcgcc acccccagcg acaagcaggg caugcccgug     1860

cugagccuga acaucaccug ccagaugaac aagaccauca ucggcgugag cgugcugagc     1920

gugcuggugg ugagcguggu ggccgugcug guguacaagu ucuacuucca ccugaugcug     1980

cuggccggcu gcaucaagua cggcagaggc gagaacaucu acgacgccuu cgugaucuac     2040

agcagccagg acgaggacug ggugagaaac gagcugguga agaaccugga ggagggcgug     2100

ccccccuucc agcugugccu gcacuacaga gacuucaucc ccggcguggc caucgccgcc     2160

aacaucaucc acgagggcuu ccacaagagc agaaagguga ucgugguggu gagccagcac     2220

uucauccaga gcagauggug caucuucgag uacgagaucg cccagaccug gcaguuccug     2280

agcagcagag ccggcaucau cuucaucgug cugcagaagg uggagaagac ccugcugaga     2340

cagcaggugg agcuguacag acugcugagc agaaacaccu accuggagug ggaggacagc     2400

gugcugggca gacacaucuu cuggagaaga cugagaaagg cccugcugga cggcaagagc     2460

uggaaccccg agggcaccgu gggcaccggc ugcaacuggc aggaggccac cagcaucuga     2520


<210>  9605
<211>  2520
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR4__Homo_sapiens__AAC80227

<400>  9605
augaugagcg ccuccagacu ggcuggcacc cucauccccg ccauggcguu ccugucuugc       60

gugcggccug agagcuggga accguguguc gagguugugc ccaacauuac auaccagugc      120

auggaacuua auuuuuauaa gaucccugac aaccugcccu ucuccacgaa aaaucucgau      180

cugucuuuua acccucuucg ccaccugggg agcuacuccu ucuuuucuuu ccccgagcuc      240

caagugcugg accugagcag augugaaauu cagaccaucg aggauggagc uuaucagucc      300

cucagccauc ugucuacacu uauucugacc ggcaauccua uccagucccu cgcccugggg      360

gccuuuagcg gacuuucuuc ccugcaaaag cucgucgcug uggagacaaa ccuggccagc      420

cuggaaaauu ucccgaucgg ccaccucaaa acccugaagg agcuuaacgu ugcucauaau      480

cugauucagu cuuuuaaacu ccccgaauac uucuccaacc ugacaaaucu ugagcaccug      540

gaccucagcu ccaacaagau ccagucuauu uauugcaccg aucugcgggu gcugcaucag      600

augccucucc ugaaucuuag ccuggaccuc ucccugaacc ccaugaauuu uauccaaccu      660

ggggccuuca aggagauucg ccuucacaaa cugacgcuca gaaacaacuu ugauagccug      720

aaugucauga agaccuguau ccagggacug gcgggccucg aagugcaccg gcugguucuu      780

ggcgaguucc gcaacgaagg gaaucuggag aaauucgaca agucugcccu cgaaggacug      840

ugcaaccuga caauugagga guuuagacuu gcuuaccucg auuauuaccu ggacgauauc      900

aucgaccugu ucaauugucu caccaacgug uccagcuuuu cucuggucag cgugacaauu      960

gaacggguga aagauuucuc cuacaauuuu ggcuggcagc aucuugagcu ggucaacugc     1020

aaguucgggc aguuucccac ccucaagcug aaaucucuga agcgccuuac guucacaagc     1080

aauaaaggag gcaacgccuu uuccgaaguu gaccucccga gccuggaguu ccuggaccuc     1140

ucuagaaaug ggcuguccuu uaagggaugu ugcagccaau cugauuucgg caccacaucc     1200

cuuaaauauc uggaccucag cuuuaacggc gugaucacca uguccucuaa uuuccugggg     1260

cuggaacagc uugagcaccu cgauuuccag cauagcaacc ugaagcaaau guccgaguuu     1320

ucuguguucc ugagccuccg gaaucugauu uaccuugaca ucucccacac ccacacacgc     1380

gucgcuuuua acggaauuuu caacggccug agcucucucg aagugcugaa aauggccgga     1440

aauuccuuuc aggagaacuu ccugccugau aucuuuacgg aacuuagaaa ucucaccuuc     1500

cuggaccuga gccaguguca gcucgagcaa cugucuccca cagcguuuaa cucccuuagc     1560

ucucugcagg uucucaauau gagccauaac aauuucuuuu cccuggauac cuucccuuau     1620

aagugccuga acagccuuca ggugcuggac uacucucuca aucacaucau gacauccaag     1680

aaacaggaac ugcaacauuu ucccagcucc cucgccuucc ugaaccuuac ccagaaugau     1740

uucgcuugca cgugugagca ccagucuuuu cugcagugga uuaaggacca acggcagcuc     1800

cuggucgagg uggaacgcau ggagugcgcc acacccagcg auaaacaggg gaugccuguu     1860

cugucccuua acaucaccug ucagaugaau aagaccauua ucggcguguc uguccugagc     1920

gugcucgucg uguccguugu ggcuguccug guguauaaau ucuacuuuca ucucaugcug     1980

cuugccgggu gcauuaagua uggaagaggc gaaaacaucu acgacgccuu cguuaucuac     2040

ucuagccaag acgaggauug ggugcggaau gagcugguca agaaccucga agagggcgug     2100

ccgcccuuuc agcugugucu gcacuauaga gacuucauuc cugggguggc uaucgcggcc     2160

aacauuaucc acgaaggauu ucauaaaucc cgcaagguua uugucguggu gagccagcac     2220

uucauccaau cucgguggug cauuuuugag uacgaaaucg cucagacaug gcaguuccuu     2280

uccagcagag ccggcaucau uuuuaucguc cugcagaaag uggagaagac ccuccugcgc     2340

caacagguug agcucuaucg gcugcuuucu agaaauacau accuggaaug ggaggauucc     2400

gugcuggggc gccauauuuu cuggcggaga cuccgcaaag cccugcuuga cggaaagagc     2460

uggaaccccg aaggcacggu cgggaccggc uguaauuggc aggaggcuac aucuaucuga     2520


<210>  9606
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS79

<400>  9606

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9607
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17462

<400>  9607
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucgcucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9608
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17462

<400>  9608
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugaccgc ccugcggggg cucucccuga acagcaaccg ccugacggug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ucaaccacac caacgugacg     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagccuguc cggggucagc     1860

cuguucuccc ucagcaccga gggcugcgac gaggaggagg ugcugaaguc ccugaaguuc     1920

agccucuucu ucgugugcac cgucacccug acgcuguucc ucaugaccau ccugaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cugcugaagc accucgacac ccaguacagc     2160

gaccagaacc gguucaaccu gugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccucc gcgacgggug gugccuggag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuca acuccgcgcu gaucauggug guggucggga gccuguccca guaccagcuc     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccugcg guggccggag     2460

gaccugcagg acgugggcug guuccuccac aagcuguccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagacgg ucgccaccau cagcuga        2577


<210>  9609
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17462

<400>  9609
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acucccucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9610
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17462

<400>  9610
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucagga ucagacguuc     1140

aaauuucuag agaagcucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaca aacucguuac ucugcccaag     1260

auaaauuuaa ccgccaaccu gauucaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

aguuccugua gcggggacca gacaccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua ugcuccaacu ggcgugggag accgagcuuu gcugggaugu auuugaaggu     1500

cugagucacc uccagguguu guaccugaac cauaauuauc uaaacagccu gccuccaggc     1560

gucuucuccc accucacggc ccugcgcggg cuuucuuuga acucgaauag acugacugug     1620

uuaagccaua augaccuccc cgcaaaccug gagauccuug acauuuccag gaaucagcug     1680

cuagcuccga acccugaugu uuuuguguca cucagugucc uggacauaac acacaauaaa     1740

uucaucugug aaugcgaguu gucuaccuuu auuaacuggc ugaaucacac uaacgugaca     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acagcuuauc cggcguuuca     1860

cucuucagcc ugucuaccga agguugcgau gaggaggaag ugcuuaaguc ccugaaguuu     1920

aguuuguucu ucgucuguac ggugacccuc acacuguuuc uaaugacuau ucugaccguc     1980

acaaaauucc ggggguuuug cuucauaugc uauaagacug cccagcgacu uguguuuaaa     2040

gaccaucccc aaggcaccga gccagauaug uacaaguaug acgcauaccu cuguuucagc     2100

ucuaaagauu uuacaugggu ucagaaugcc cuguugaagc accuggacac ccaguauucc     2160

gaucagaacc gcuucaacuu augcuuugaa gagagagacu ucgugcccgg agaaaauagg     2220

aucgcuaaca uucaagaugc gaucuggaau agucggaaga uuguaugucu cgucucacgc     2280

cauuuucuga gagacggcug gugccuugag gcauucagcu acgcccaggg gaggugucug     2340

ucggacuuga acuccgcucu caucauggug guugugggau cucugagcca guaucagcua     2400

augaaacacc aaucaauacg ugguuucguc cagaagcagc aauaccugcg guggccugag     2460

gaucuucagg acgugggcug guuucuccac aaacugaguc agcagaucuu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaacauucca uuacaaacug uagccacgau cuccuga        2577


<210>  9611
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17462

<400>  9611
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagccugag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9612
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17462

<400>  9612
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagaccuuc     1140

aaauuucugg agaagcugca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaca aacuggugac acuucccaag     1260

aucaaucuga ccgcuaaccu cauucaccug ucugaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

uccagcuguu cuggagacca gacaccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcaacu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugucccacc uucagguucu cuaccugaac cauaauuauc uuaacucucu gccucccgga     1560

guguucagcc accucaccgc ccugcggggc cugucccuua auucuaacag acugacaguc     1620

cucagccaua augaccugcc cgcuaaccuc gagauccugg acauuucccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuagc cucucugugc uggacaucac gcacaauaaa     1740

uucauuugug aaugcgagcu guccaccuuu aucaacuggc uuaaucacac aaacgucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acagccuguc uggcgucucc     1860

cucuucagcc ugucuacaga aggaugcgau gaggaggaag ugcucaagag ccugaaguuu     1920

ucccuuuucu ucguuuguac cgugacgcug acacucuuuc ugaugaccau ucugaccguc     1980

acaaaauucc ggggcuuuug cuucaucugc uauaagaccg cccagagacu uguguuuaaa     2040

gaccauccuc aagggacaga gcccgauaug uacaaguaug acgccuaccu guguuucagc     2100

ucuaaagauu uuacgugggu ucagaaugcu cuccugaagc accucgacac ccaguauucc     2160

gaucagaacc gcuucaaccu gugcuuugag gaacgggacu ucgugccggg agaaaauaga     2220

aucgccaaca uucaagaugc gaucuggaau agccgcaaga uugucugucu ugugucccgg     2280

cauuuucuga gagacggcug gugccuggag gcuuucucuu acgcccaggg gcgcugucuc     2340

agcgaccuga acuccgcccu uaucauggug guugucggcu cucugagcca guaucagcuc     2400

augaaacacc aauccauucg gggauucgug cagaagcagc aauaccugag auggccugag     2460

gaucuccagg acgugggcug guuucugcac aaacuuucuc agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaacaucccc cugcaaacag ucgcuaccau uagcuga        2577


<210>  9613
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS82

<400>  9613

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Ile Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9614
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17465

<400>  9614
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauauccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucguucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9615
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17465

<400>  9615
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacauccccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacgcgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

acguucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacccuggac cuccgggaca acgcccugac gaccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga ccgcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacgcccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugaccgc ccugcggggg cucucccuga acagcaaccg ccugaccgug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac gcacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ucaaccacac caacgugacc     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagcuucuc cggggucagc     1860

cuguucuccc ugagcacgga gggcugcgac gaggaggagg ugcucaaguc ccugaaguuc     1920

agccuguucu ucgugugcac cgucacccuc acccuguucc ugaugacgau ccucaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu gguguucaag     2040

gaccaccccc aggggacgga gcccgacaug uacaaguacg acgccuaccu gugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac ccaguacagc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccugc gcgacgggug gugccucgag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuga acuccgcgcu caucauggug guggucggga gccuguccca guaccagcug     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acgugggcug guuccugcac aagcucuccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg ucgccacgau cagcuga        2577


<210>  9616
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17465

<400>  9616
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacauccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acuccuucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9617
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17465

<400>  9617
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacauccccc ugacaauuga uaaggaagcc uuucgaaauc ucccuaacuu acguauccug      300

gaccuuggau ccucuaaaau uuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacucggcug gacuuaucaa agaaccagau ccgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuauagauuu cagcuccaac      540

cagaucuuuu ugguguguga acacgagcua gagccucugc agggcaagac ccucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauu uuggaugugu cagggaacgg auggacagua      720

gacaucaccg guaauuuuag caacgcuauu aguaagucuc aagcauucuc ccucauccug      780

gcccaucaca uaaugggcgc uggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

acuuuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagaca cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga ucaauaagau ugccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaagucgccu acaucgaccu gcagaagaac cauaucgcaa uuauacagga ucagaccuuc     1140

aaauuucuag agaagcucca gacgcuggac cuuagagaua augcuuugac uaccauccac     1200

uucauuccau cuaucccgga cauauuucug agcggcaaca aacucguuac acugcccaag     1260

auuaauuuaa cugccaaccu gauccaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauucuga uccuuaauca gaaccguuuu     1380

aguuccugua gcggggacca gaccccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua ugcuccaacu ggcgugggag acagagcuuu gcugggaugu auuugaaggu     1500

cugagucacc uccagguguu guaccugaac cauaauuauc uaaacagccu gccuccaggc     1560

gucuucuccc accucaccgc ccugcgcggg cuuucuuuga acucgaauag acugacggug     1620

uuaagccaua augaccuccc cgcaaaccug gagauucuug acauauccag gaaucagcug     1680

cuagcuccga acccugaugu uuuuguguca cucagugucc uggacaucac ucacaauaaa     1740

uucauuugug aaugcgaguu gucuacauuu aucaacuggc ugaaucacac caacgugacu     1800

aucgccggac ccccagcuga uauuuacugu guauacccug acagcuucuc cggcguuuca     1860

uuauuuagcc ucucuacaga agguugcgau gaggaggaag ugcugaaguc ccuuaaguuc     1920

agucuguucu uugucuguac cgugacguug acccucuucc ugaugacaau acuaacuguc     1980

accaaauuuc ggggguucug cuuuaucugc uauaagacag cccagcgacu gguguucaaa     2040

gaccaucccc aaggcacuga gccagauaug uacaaguaug acgcauaccu uuguuuuagc     2100

ucuaaagauu ucaccugggu ucagaaugcc cuccugaagc acuuggacac acaguauucc     2160

gaucagaacc gcuuuaaccu gugcuucgaa gagagagacu uugugcccgg agaaaauagg     2220

auugcuaaca uccaagaugc gauuuggaau agucggaaga ucguauguuu agucucacgc     2280

cauuuccuca gagacggcug gugccuggag gcauucagcu acgcccaggg gaggugucuu     2340

ucggaccuga acuccgcuuu gauaauggug guugugggau cucucagcca guaucagcug     2400

augaaacacc aaucaauccg ugguuuuguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acgugggcug guuccuucac aaacucaguc agcagauucu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaacauccca uugcaaaccg uagccacuau uuccuga        2577


<210>  9618
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17465

<400>  9618
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacauccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagcuucag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9619
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17465

<400>  9619
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacauuccuc ugaccaucga uaaggaagcg uuucggaauc uccccaaccu gcgcauucuu      300

gaccugggca gcuccaaaau cuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacacgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccauugauuu cagcucuaac      540

cagaucuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac ccucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauu cucgauguuu ccggcaacgg guggacagug      720

gacaucaccg gaaauuuuuc uaacgcuauu agcaaguccc aagccuucag ccugauccug      780

gcgcaucaca uuaugggcgc cggguuugga uuccacaaua ucaaagaucc cgaccagaac      840

acguuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagacc cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau ugccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aaaguggccu acaucgaccu gcagaagaac cauauugcua ucauucaaga ucagacauuc     1140

aaauuucugg agaagcugca gacccucgac cugagagaua augcccugac aaccauccac     1200

uucauccccu ccauuccuga caucuuucuc agcgggaaca aacuggugac gcuucccaag     1260

auuaaucuga cagcuaaccu cauccaccug ucugaaaauc ggcuggagaa ccuugauauu     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauccuga uccuuaauca gaacagauuu     1380

uccagcuguu cuggagacca gaccccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcaacu ugccugggag acagagcucu gcugggaugu guuugaaggg     1500

cugucccauc ugcagguucu cuaccugaac cacaauuauc uuaacucucu gccucccgga     1560

guguucagcc accucaccgc ccugcggggc cugucccuua auucuaacag acugaccguc     1620

cucagccaua augaccugcc cgcuaaccuc gagauucugg acaucucccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuagc cucucugugc uggacauuac acacaauaaa     1740

uucaucugug aaugcgagcu guccacguuu auuaacuggc uuaaucacac caacgucaca     1800

aucgccgggc ccccugcuga uauuuacugu guguaccccg acagcuucuc uggcgucucc     1860

cuguuuagcc ucucuaccga aggaugcgau gaggaggaag ugcuuaagag ccucaaguuc     1920

ucccuguucu uuguuuguac agugacccuu acgcuguucc ucaugacaau ccugaccguc     1980

accaaauuuc ggggcuucug cuuuaucugc uauaagacag cccagagacu gguguucaaa     2040

gaccauccuc aagggaccga gcccgauaug uacaaguaug acgccuaccu uuguuuuagc     2100

ucuaaagauu ucacaugggu ucagaaugcu cugcucaagc accuggacac gcaguauucc     2160

gaucagaacc gcuuuaaccu cugcuucgag gaacgggacu uugugccggg agaaaauaga     2220

auugccaaca uccaagaugc gauuuggaau agccgcaaga ucgucugucu ggugucccgg     2280

cauuuccuua gagacggcug gugccuggag gcuuucucuu acgcccaggg gcgcugucug     2340

agcgaccuca acuccgcccu gauuauggug guugucggcu cucuuagcca guaucagcug     2400

augaaacacc aauccauccg gggauuugug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acgugggcug guuccuccac aaacugucuc agcagauccu uaagaaagaa     2520

aaggagaaga aaaaggauaa uaacauuccc cugcaaaccg ucgcuacaau cagcuga        2577


<210>  9620
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS83

<400>  9620

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Lys Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9621
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17466

<400>  9621
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

aaaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucgcucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9622
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17466

<400>  9622
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

aagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugaccgc ccugcggggg cucucccuga acagcaaccg ccugacggug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ucaaccacac caacgugacg     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagccuguc cggggucagc     1860

cuguucuccc ucagcaccga gggcugcgac gaggaggagg ugcugaaguc ccugaaguuc     1920

agccucuucu ucgugugcac cgucacccug acgcuguucc ucaugaccau ccugaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cugcugaagc accucgacac ccaguacagc     2160

gaccagaacc gguucaaccu gugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccucc gcgacgggug gugccuggag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuca acuccgcgcu gaucauggug guggucggga gccuguccca guaccagcuc     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccugcg guggccggag     2460

gaccugcagg acgugggcug guuccuccac aagcuguccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagacgg ucgccaccau cagcuga        2577


<210>  9623
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17466

<400>  9623
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

aagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acucccucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9624
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17466

<400>  9624
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

aagauauuuu ugguguguga acacgagcua gagccucugc agggcaaaac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caagugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaaaucuc aggcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaggaucc cgaccaaaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaagauc uuaagguguu gaaucuggca      960

uacaacaaga uuaauaaaau cgccgacgag gcuuuuuacg ggcucgauaa ccuucaggug     1020

cugaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaggucgccu acauugaccu gcagaaaaac cauaucgcaa ucauucagga ucaaacguuc     1140

aaguuucuag agaaacucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaca agcucguuac ucugcccaaa     1260

auaaauuuaa ccgccaaccu gauucaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc cagauccuga uucuuaauca aaaccguuuu     1380

aguuccugua gcggggacca gacaccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua ugcuccagcu ggcgugggag accgagcuuu gcugggaugu auuugaaggu     1500

cugagucacu ugcaagugcu cuaccugaac cauaauuauc uaaacagccu gccuccaggc     1560

gucuucuccc accucacggc ccugcgcggg cuuucuuuga acucgaauag acugacugug     1620

uuaagccaua augaccuccc cgcaaaccug gagauccuug acauuuccag gaaucagcug     1680

cuagcuccga acccugaugu uuuuguguca cucagugucc uggacauaac acacaauaag     1740

uucaucugug aaugcgaguu gucuaccuuu auuaacuggc ugaaucacac uaacgugaca     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acagcuuauc cggcguuuca     1860

cucuucagcc ugucuaccga agguugcgau gaggaggaag ugcuuaaguc ccugaaauuu     1920

aguuuguucu ucgucuguac ggugacccuc acacuguuuc uaaugacuau ucugaccguc     1980

acaaaguucc ggggguuuug cuucauaugc uauaaaacug cccagcgacu uguguuuaag     2040

gaccaucccc agggcaccga gccagauaug uacaaauaug acgcauaccu cuguuucagc     2100

ucuaaggauu uuacaugggu ucaaaaugcc cuguugaagc accuggacac ccaguauucc     2160

gaucagaacc gcuucaacuu augcuuugaa gagagagacu ucgugcccgg agaaaauagg     2220

aucgcuaaca uucaggaugc gaucuggaau agucggaaaa uuguaugucu cgucucacgc     2280

cauuuucuga gagacggcug gugccuugag gcauucagcu acgcccaagg gaggugucug     2340

ucggacuuga acuccgcucu caucauggug guugugggau cucugagcca guaucagcua     2400

augaagcacc agucaauacg ugguuucguc caaaaacagc aguaccugcg guggccugag     2460

gaucuucaag acgugggcug guuucuccac aagcugaguc agcagaucuu gaaaaaggaa     2520

aaggagaaaa agaaagauaa uaacauucca uuacagacug uagccacgau cuccuga        2577


<210>  9625
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17466

<400>  9625
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

aagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagccugag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9626
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17466

<400>  9626
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

aagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaaaac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaagugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaauccc aggccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaggaucc cgaccaaaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaagauc ugaagguccu gaaucuugcu      960

uacaacaaga ucaauaaaau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aagguggccu acauugaccu gcagaaaaac cauaucgcua uuauccagga ucaaaccuuc     1140

aaguuucugg agaaacuuca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaca agcuggugac acuucccaaa     1260

aucaaucuga ccgcuaaccu cauucaccug ucugaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc cagauucuga uccuuaauca aaacagauuu     1380

uccagcuguu cuggagacca gacaccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcagcu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugucccacc uucaaguucu cuaccugaac cauaauuauc uuaacucucu gccucccgga     1560

guguucagcc accucaccgc ccugcggggc cugucccuua auucuaacag acugacaguc     1620

cucagccaua augaccugcc cgcuaaccuc gagauccugg acauuucccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuagc cucucugugc uggacaucac gcacaauaag     1740

uucauuugug aaugcgagcu guccaccuuu aucaacuggc uuaaucacac aaacgucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acagccuguc uggcgucucc     1860

cucuucagcc ugucuacaga aggaugcgau gaggaggaag ugcucaagag ccugaaauuu     1920

ucccuuuucu ucguuuguac cgugacgcug acacucuuuc ugaugaccau ucugaccguc     1980

acaaaguucc ggggcuuuug cuucaucugc uauaaaaccg cccagagacu uguguuuaag     2040

gaccauccuc aggggacaga gcccgauaug uacaaauaug acgccuaccu guguuucagc     2100

ucuaaggauu uuacgugggu ucaaaaugcu cuccugaagc accucgacac ccaguauucc     2160

gaucagaacc gcuucaaccu gugcuuugag gaacgggacu ucgugccggg agaaaauaga     2220

aucgccaaca uucaggaugc gaucuggaau agccgcaaaa uugucugucu ugugucccgg     2280

cauuuucuga gagacggcug gugccuggag gcuuucucuu acgcccaagg gcgcugucuc     2340

agcgaccuga acuccgcccu uaucauggug guugucggcu cucugagcca guaucagcuc     2400

augaagcacc aguccauucg gggauucgug caaaaacagc aguaccugag auggccugag     2460

gaucuccaag acgugggcug guuucugcac aagcugucuc agcagauccu gaaaaaggaa     2520

aaggagaaaa agaaagauaa uaacaucccc cugcagacag ucgcuaccau uagcuga        2577


<210>  9627
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS84

<400>  9627

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Ile Leu Gln Ile Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Gly Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9628
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17467

<400>  9628
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uauugcaaau ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucgcucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aagcucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaaggcaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9629
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17467

<400>  9629
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca uccugcagau cgccugggag accgagcugu gcugggacgu guucgagggg     1500

cucagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu gccgcccggc     1560

guguucagcc accucaccgc ccugcggggg cugucccuca acagcaaccg ccugacggug     1620

cugucccaca acgaccuccc cgccaaccug gagauccugg acaucagccg gaaccagcuc     1680

cuggccccca accccgacgu cuucgugucc cugagcgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ugaaccacac caacgugacg     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagccucuc cggggucagc     1860

cuguucuccc ugagcaccga gggcugcgac gaggaggagg ugcucaaguc ccugaaguuc     1920

agccuguucu ucgugugcac cgucacccuc acgcuguucc ugaugaccau ccucaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu gugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac ccaguacagc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccugc gcgacgggug gugccucgag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuga acuccgcgcu caucauggug guggucggga gccuguccca guaccagcug     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acgugggcug guuccugcac aagcucuccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggggaa caacaucccc cugcagacgg ucgccaccau cagcuga        2577


<210>  9630
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17467

<400>  9630
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca uccuccagau cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acucccucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaagggcaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9631
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17467

<400>  9631
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccuucaggug     1020

cugaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucaaga ucagacguuc     1140

aaauuucuag agaagcucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaca aacucguuac ucugcccaag     1260

auaaauuuaa ccgccaaccu gauucaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

aguuccugua gcggggacca gacaccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua uccuccaaau ugcgugggag accgagcugu gcugggaugu auuugaaggu     1500

cuuagucacu ugcaagugcu guaccucaac cauaauuauc ugaacagccu accuccaggc     1560

gucuucuccc accugacggc ccuccgcggg cugucucuua auucgaacag auugacugug     1620

cugagccaua augacuuacc cgcaaaccuc gagauacugg acaucuccag gaaucagcuu     1680

cuggcuccga acccugaugu uuuuguguca cuaagugucc ucgacauuac acacaauaaa     1740

uucaucugug aaugcgagcu gucuaccuuu aucaacuggu ugaaucacac uaacgugaca     1800

auugccggac ccccagcuga uauauacugu guauacccug acagccuguc cggcguuuca     1860

uuauucagcc ucucuaccga agguugcgau gaggaggaag ugcugaaguc ccuuaaguuu     1920

agucuguucu ucgucuguac ggugaccuug acacucuuuc ugaugacuau ccuaaccguc     1980

acaaaauucc ggggguuuug cuucauuugc uauaagacug cccagcgacu gguguuuaaa     2040

gaccaucccc agggcaccga gccagauaug uacaaguaug acgcauaccu uuguuucagc     2100

ucuaaagauu uuacaugggu ucagaaugcc cuccugaagc acuuggacac ccaguauucc     2160

gaucagaacc gcuucaaccu gugcuuugaa gagagagacu ucgugcccgg agaaaauagg     2220

aucgcuaaca uucaagaugc gaucuggaau agucggaaga uaguauguuu agucucacgc     2280

cauuuucuca gagacggcug gugccuggag gcauucagcu acgcccaggg gaggugucuu     2340

ucggaccuga acuccgcuuu gaucauggug guugugggau cucucagcca guaucagcug     2400

augaaacacc aaucaauucg ugguuucguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acgugggcug guuucuucac aaacucaguc agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggggaa uaacauucca uugcaaacug uagccacgau cuccuga        2577


<210>  9632
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17467

<400>  9632
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca uccugcagau cgccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagccugag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaagggcaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9633
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17467

<400>  9633
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagaccuuc     1140

aaauuucugg agaagcugca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaca aacuggugac acuucccaag     1260

aucaaucuga ccgcuaaccu cauucaccug ucugaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

uccagcuguu cuggagacca gacaccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua uccugcaaau ugccugggag accgagcuuu gcugggaugu guuugaaggg     1500

cucucccauc ugcagguucu guaccucaac cacaauuauc ugaacucucu uccucccgga     1560

guguucagcc accugaccgc ccuccggggc cugucccuua auucuaacag acuuacaguc     1620

cugagccaua augaccuccc cgcuaaccug gagauccucg acauuucccg caaucagcug     1680

cuugcgccua acccggaugu guuuguuagc cugucugugc ucgacaucac gcacaauaaa     1740

uucauuugug aaugcgagcu guccaccuuu aucaacuggc ugaaucacac aaacgucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acagccuuuc uggcgucucc     1860

cuguucagcc ucucuacaga aggaugcgau gaggaggaag ugcucaagag ccugaaguuu     1920

ucccuguucu ucguuuguac cgugacgcuu acacuguuuc ucaugaccau ccugaccguc     1980

acaaaauucc ggggcuuuug cuucauuugc uauaagaccg cccagagacu gguguuuaaa     2040

gaccauccuc aagggacaga gcccgauaug uacaaguaug acgccuaccu uuguuucagc     2100

ucuaaagauu uuacgugggu ucagaaugcu cugcucaagc accuggacac ccaguauucc     2160

gaucagaacc gcuucaaccu cugcuuugag gaacgggacu ucgugccggg agaaaauaga     2220

aucgccaaca uucaagaugc gaucuggaau agccgcaaga uugucugucu ggugucccgg     2280

cauuuucuua gagacggcug gugccuggag gcuuucucuu acgcccaggg gcgcugucug     2340

agcgaccuca acuccgcccu gaucauggug guugucggcu cucuuagcca guaucagcug     2400

augaaacacc aauccauccg gggauucgug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acgugggcug guuucuccac aaacugucuc agcagauucu uaagaaagaa     2520

aaggagaaga aaaaggggaa uaacaucccc cugcaaacag ucgcuaccau uagcuga        2577


<210>  9634
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS85

<400>  9634

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9635
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17468

<400>  9635
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucgcucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuuca uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9636
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17468

<400>  9636
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugaccgc ccugcggggg cucucccuga acagcaaccg ccugacggug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ucaaccacac caacgugacg     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagccuguc cggggucagc     1860

cuguucuccc ucagcaccga gggcugcgac gaggaggagg ugcugaaguc ccugaaguuc     1920

agccucuuca ucgugugcac cgucacccug acgcuguucc ucaugaccau ccugaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cugcugaagc accucgacac ccaguacagc     2160

gaccagaacc gguucaaccu gugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccucc gcgacgggug gugccuggag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuca acuccgcgcu gaucauggug guggucggga gccuguccca guaccagcuc     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccugcg guggccggag     2460

gaccugcagg acgugggcug guuccuccac aagcuguccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagacgg ucgccaccau cagcuga        2577


<210>  9637
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17468

<400>  9637
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acucccucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuuca ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9638
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17468

<400>  9638
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucagga ucagacguuc     1140

aaauuucuag agaagcucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaca aacucguuac ucugcccaag     1260

auaaauuuaa ccgccaaccu gauucaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

aguuccugua gcggggacca gacaccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua ugcuccaacu ggcgugggag accgagcuuu gcugggaugu auuugaaggu     1500

cugagucacc uccagguguu guaccugaac cauaauuauc uaaacagccu gccuccaggc     1560

gucuucuccc accucacggc ccugcgcggg cuuucuuuga acucgaauag acugacugug     1620

uuaagccaua augaccuccc cgcaaaccug gagauccuug acauuuccag gaaucagcug     1680

cuagcuccga acccugaugu uuuuguguca cucagugucc uggacauaac acacaauaaa     1740

uucaucugug aaugcgaguu gucuaccuuu auuaacuggc ugaaucacac uaacgugaca     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acagcuuauc cggcguuuca     1860

cucuucagcc ugucuaccga agguugcgau gaggaggaag ugcuuaaguc ccugaaguuu     1920

aguuuguuca uugucuguac ggugacccuc acacuguucc uaaugacuau acugaccguc     1980

acaaaauuuc ggggguucug cuuuaucugc uauaagacug cccagcgacu uguguucaaa     2040

gaccaucccc aaggcaccga gccagauaug uacaaguaug acgcauaccu cuguuuuagc     2100

ucuaaagauu ucacaugggu ucagaaugcc cuguugaagc accuggacac ccaguauucc     2160

gaucagaacc gcuuuaacuu augcuucgaa gagagagacu uugugcccgg agaaaauagg     2220

auugcuaaca uccaagaugc gauuuggaau agucggaaga ucguaugucu cgucucacgc     2280

cauuuccuga gagacggcug gugccuugag gcauuuagcu acgcccaggg gaggugucug     2340

ucggacuuga acuccgcucu cauaauggug guugugggau cucugagcca guaucagcua     2400

augaaacacc aaucaauccg ugguuucguc cagaagcagc aauaccugcg guggccugag     2460

gaucuucagg acgugggcug guuccuccac aaacugaguc agcagauuuu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaacauccca uuacaaacug uagccacgau uuccuga        2577


<210>  9639
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17468

<400>  9639
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagccugag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguuca ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9640
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17468

<400>  9640
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagaccuuc     1140

aaauuucugg agaagcugca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaca aacuggugac acuucccaag     1260

aucaaucuga ccgcuaaccu cauucaccug ucugaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

uccagcuguu cuggagacca gacaccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcaacu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugucccacc uucagguucu cuaccugaac cauaauuauc uuaacucucu gccucccgga     1560

guguucagcc accucaccgc ccugcggggc cugucccuua auucuaacag acugacaguc     1620

cucagccaua augaccugcc cgcuaaccuc gagauccugg acauuucccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuagc cucucugugc uggacaucac gcacaauaaa     1740

uucauuugug aaugcgagcu guccaccuuu aucaacuggc uuaaucacac aaacgucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acagccuguc uggcgucucc     1860

cucuucagcc ugucuacaga aggaugcgau gaggaggaag ugcucaagag ccugaaguuu     1920

ucccuuuuca uuguuuguac cgugacgcug acacucuucc ugaugaccau ccugaccguc     1980

acaaaauuuc ggggcuucug cuuuaucugc uauaagaccg cccagagacu uguguucaaa     2040

gaccauccuc aagggacaga gcccgauaug uacaaguaug acgccuaccu guguuuuagc     2100

ucuaaagauu ucacgugggu ucagaaugcu cuccugaagc accucgacac ccaguauucc     2160

gaucagaacc gcuuuaaccu gugcuucgag gaacgggacu uugugccggg agaaaauaga     2220

auugccaaca uccaagaugc gauuuggaau agccgcaaga ucgucugucu ugugucccgg     2280

cauuuccuga gagacggcug gugccuggag gcuuuuucuu acgcccaggg gcgcugucuc     2340

agcgaccuga acuccgcccu uauuauggug guugucggcu cucugagcca guaucagcuc     2400

augaaacacc aauccauccg gggauucgug cagaagcagc aauaccugag auggccugag     2460

gaucuccagg acgugggcug guuccugcac aaacuuucuc agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaacauuccc cugcaaacag ucgcuaccau cagcuga        2577


<210>  9641
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS87

<400>  9641

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Thr Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9642
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17470

<400>  9642
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaacuu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucguucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9643
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17470

<400>  9643
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaccc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggacggug      720

gacaucaccg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagacguuc     1140

aaguuccucg agaagcugca gacccuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac gcugcccaag     1260

aucaaccuga ccgcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugacggc ccugcggggg cucucccuga acagcaaccg ccugaccgug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucaacuggc ucaaccacac gaacgugacc     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acagcuucuc cggggucagc     1860

cuguucuccc ugagcaccga gggcugcgac gaggaggagg ugcucaaguc ccugaaguuc     1920

agccuguucu ucgugugcac cgucacgcuc acccuguucc ugaugaccau ccucaccgug     1980

acgaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu gugcuucucc     2100

agcaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac gcaguacagc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac ucccgcaaga ucgugugccu ggucagccgg     2280

cacuuccugc gcgacgggug gugccucgag gccuucuccu acgcccaggg ccggugccug     2340

agcgaccuga acuccgcgcu caucauggug guggucggga gccuguccca guaccagcug     2400

augaagcacc agagcauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acgugggcug guuccugcac aagcucuccc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg ucgccaccau cagcuga        2577


<210>  9644
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17470

<400>  9644
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaccc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acuccuucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9645
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17470

<400>  9645
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaccu ugaaagcccu cacacggcug gacuuaucaa agaaucagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaac ucccugaagu cuaucgauuu cagcuccaau      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac ccucucauuc      600

uuuagucugg cagccaacag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aauccauuca ggaacauggu ccuggaaauc uuggaugugu cagggaaugg auggacugua      720

gacauuacag guaacuuuag caaugcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaca uaaaagaucc cgaccagaau      840

accuuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacg cugaaggauc uuaaaguguu gaaccuggca      960

uacaauaaga uuaacaagau cgccgacgag gcuuuuuacg ggcucgauaa ucugcaagug     1020

cuuaaccuga guuauaauuu gcucggagaa cuguacagcu ccaacuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaau cauaucgcaa ucauucagga ucagacuuuc     1140

aaauuucuag agaagcucca gacccuggac cuuagagaua acgcuuugac aacuauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaua aacucguuac ccugcccaag     1260

auaaacuuaa cagccaaucu gauucaccuu ucagaaaaca gguuggagaa ucucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaacca gaaucguuuu     1380

aguuccugua gcggggacca gaccccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaca ugcuccaacu ggcgugggag acggagcuuu gcugggaugu auuugaaggu     1500

cugagucacc uccagguguu guaccugaau cauaacuauc uaaauagccu gccuccaggc     1560

gucuucuccc accucacugc ccugcgcggg cuuucuuuga acucgaauag acugacagug     1620

uuaagccaua acgaccuccc cgcaaaucug gagauccuug acauuuccag gaaccagcug     1680

cuagcuccga auccugaugu uuuuguguca cucagugucc uggacauaac ccacaacaaa     1740

uucaucugug aaugcgaguu gucuacuuuu auuaauuggc ugaaccacac aaaugugacc     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acagcuucuc cggcguuuca     1860

uuauuuagcc ucucuacgga agguugcgau gaggaggaag ugcugaaguc ccuuaaguuc     1920

agucuguucu uugucuguac cgugacauug acucucuucc ugaugaccau ucuaacaguc     1980

acuaaauuuc ggggguucug cuuuauaugc uauaagaccg cccagcgacu gguguucaaa     2040

gaccaucccc aaggcacaga gccagauaug uacaaguaug acgcauaccu uuguuuuagc     2100

ucuaaagauu ucaccugggu ucagaacgcc cuccugaagc acuuggacac ucaguauucc     2160

gaucagaauc gcuuuaaccu gugcuucgaa gagagagacu uugugcccgg agaaaacagg     2220

aucgcuaaua uucaagaugc gaucuggaac ucacggaaga uuguauguuu agucagucgc     2280

cauuuccuca gagacggcug gugccuggag gcauucagcu acgcccaggg gaggugucuu     2340

ucggaccuga acuccgcuuu gaucauggug guugugggau cucucagcca guaucagcug     2400

augaaacacc aaucaauacg ugguuuuguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acgugggcug guuccuucac aaacucaguc agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaauauucca uugcaaacgg uagccacaau cuccuga        2577


<210>  9646
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17470

<400>  9646
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaccc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagcuucag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9647
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17470

<400>  9647
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaccc ucaaagcccu gacacgccuu gaccugagca agaaucagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacugaac ucucucaagu ccaucgauuu cagcucuaau      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac ccucuccuuc      600

uuuagccugg cugccaacuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aauccguucc gcaacauggu gcuggaaauc cucgauguuu ccggcaaugg guggacggug      720

gacauuaccg gaaacuuuuc uaaugcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaca uuaaagaucc cgaccagaau      840

acauuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagacc cucaaggauc ugaaaguccu gaaccuugcu      960

uacaauaaga ucaacaagau cgccgacgaa gcguuuuacg ggcucgauaa ucugcagguu     1020

cugaaccucu ccuauaaucu gcuuggagag cuguacucua gcaacuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaau cauaucgcua uuauccaaga ucagacauuc     1140

aaauuucugg agaagcugca gacccucgac cugagagaua acgcccugac gacaauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaua aacuggugac ccuucccaag     1260

aucaaccuga cagcuaaucu cauucaccug ucugaaaacc ggcuggagaa ucuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaacca gaauagauuu     1380

uccagcuguu cuggagacca gaccccuucc gaaaacccca gccuggagca acucuuccug     1440

ggcgaaaaca ugcugcagcu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugucccauc ugcagguucu cuaccugaau cacaacuauc uuaauucucu gccucccgga     1560

guguucagcc accucacagc ccugcggggc cugucccuua acucuaauag acugacgguc     1620

cucagccaua acgaccugcc cgcuaaucuc gagauccugg acauuucccg caaccagcuu     1680

cuggcgccua auccggaugu guuuguuagc cucucugugc uggacaucac ccacaacaaa     1740

uucauuugug aaugcgagcu guccacauuu aucaauuggc uuaaccacac caaugucaca     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acagcuucuc uggcgucucc     1860

cuguuuagcc ucucuaccga aggaugcgau gaggaggaag ugcuuaagag ccucaaguuc     1920

ucccuguucu uuguuuguac ggugacacuu acccuguucc ucaugaccau ucugacaguc     1980

accaaauuuc ggggcuucug cuuuaucugc uauaagacag cccagagacu gguguucaaa     2040

gaccauccuc aagggacgga gcccgauaug uacaaguaug acgccuaccu uuguuuuagc     2100

ucuaaagauu ucaccugggu ucagaacgcu cugcucaagc accuggacac acaguauucc     2160

gaucagaauc gcuuuaaccu cugcuucgag gaacgggacu uugugccggg agaaaacaga     2220

aucgccaaua uucaagaugc gaucuggaac agccgcaaga uugucugucu ggugucccgg     2280

cauuuccuua gagacggcug gugccuggag gcuuucucuu acgcccaggg gcgcugucug     2340

agcgaccuca auuccgcccu gaucauggug guugucggcu cucuuagcca guaucagcug     2400

augaaacacc aauccauucg gggauuugug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acgugggcug guuccuccac aaacugucuc agcagauccu uaagaaagaa     2520

aaggagaaga aaaaggauaa caauaucccc cugcaaaccg ucgcuacaau uagcuga        2577


<210>  9648
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS88

<400>  9648

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Gly Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9649
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17471

<400>  9649
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacgguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucguucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9650
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17471

<400>  9650
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacggcu ccaacuucua cgggcugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucaucccca gcaucccgga caucuuccug uccggcaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug agcgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

uccagcugcu ccggcgacca gacccccagc gagaacccgu cccuggagca gcuguuccuc     1440

ggggagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggc     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacagccu cccgcccggg     1560

guguucuccc accugaccgc ccugcggggc cucagccuga acuccaaccg ccugacggug     1620

cucagccaca acgaccugcc cgccaaccug gagauccucg acaucucccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugagc cucuccgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ucaaccacac caacgugacg     1800

aucgcggggc cgcccgccga caucuacugc guguaccccg acuccuucag cggcgucucc     1860

cuguucagcc uguccaccga gggcugcgac gaggaggagg ugcucaagag ccugaaguuc     1920

ucccuguucu ucgugugcac cgucacccuc acgcuguucc ugaugaccau ccucaccgug     1980

accaaguucc gcggguucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac ccaguacagc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg ggagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac agccgcaaga ucgugugccu ggucucccgg     2280

cacuuccugc gcgacggcug gugccucgag gccuucagcu acgcccaggg gcggugccug     2340

uccgaccuga acagcgcgcu caucauggug guggucggcu cccugagcca guaccagcug     2400

augaagcacc aguccauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acguggggug guuccugcac aagcucagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagacgg ucgccaccau cuccuga        2577


<210>  9651
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17471

<400>  9651
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacggcu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acuccuucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9652
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17471

<400>  9652
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucuga guuauaacuu gcucggagaa cuguacggca gcaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucagga ucagacguuc     1140

aaauuucuag agaagcucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau ccauuccgga caucuuucug ucugggaaca aacucguuac ucugcccaag     1260

auaaauuuaa ccgccaaccu gauucaccuu agcgaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

ucaaguuguu ccggagacca gacaccaagc gaaaaccccu cuuuggagca gcuguucuua     1440

ggugaaaaua ugcuccaacu ggcgugggag accgagcuuu gcugggaugu auuugaaggc     1500

cugucacacc uccagguguu guaccugaac cauaauuauc uaaacagucu gccuccaggg     1560

gucuucagcc accucacggc ccugcgcgga cuuuccuuga acucuaauag acugacugug     1620

uuaucgcaua augaccuccc cgcaaaccug gagauccuug acauuagcag gaaucagcug     1680

cuagcuccga acccugaugu uuuugugucc cucucagucc uggacauaac acacaauaaa     1740

uucaucugug aaugcgaguu gaguaccuuu auuaacuggc ugaaucacac uaacgugaca     1800

aucgccgguc ccccagcuga uaucuacugu guauacccug acucuuucag cggcguuucc     1860

uuauuuucac ucagcaccga agggugcgau gaggaggaag ugcugaaguc ucuuaaguuc     1920

ucccuguucu uugucuguac ggugaccuug acacucuucc ugaugacuau ucuaaccguc     1980

acaaaauuuc ggggcuucug cuuuauaugc uauaagacug cccagcgacu gguguucaaa     2040

gaccaucccc aaggaaccga gccagauaug uacaaguaug acgcauaccu uuguuuuagu     2100

agcaaagauu ucacaugggu ucagaaugcc cuccugaagc acuuggacac ccaguauucu     2160

gaucagaacc gcuuuaaccu gugcuucgaa gagagagacu uugugcccgg cgaaaauagg     2220

aucgcuaaca uucaagaugc gaucuggaac ucccggaaga uuguauguuu agucucacgc     2280

cauuuccuca gagacgggug gugccuggag gcauucaguu acgcccaggg aaggugucuu     2340

agcgaccuga acucggcuuu gaucauggug guuguggguu cccucucuca guaucagcug     2400

augaaacacc aaagcauacg uggcuuuguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acguggggug guuccuucac aaacucucac agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaauauucca uugcaaacug uagccacgau caguuga        2577


<210>  9653
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17471

<400>  9653
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacggca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagcuucag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9654
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17471

<400>  9654
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacggcu cuaauuucua ugggcucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagaccuuc     1140

aaauuucugg agaagcugca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucaucccca gcaucccuga cauuuuucuc uccggaaaca aacuggugac acuucccaag     1260

aucaaucuga ccgcuaaccu cauucaccug agcgaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

ucuuccugua gcggcgacca gacaccuucu gaaaaccccu cccuggagca gcuguuccug     1440

ggggaaaaua ugcugcaacu ugccugggag accgagcucu gcugggaugu guuugaagga     1500

cugagccacc uucagguucu cuaccugaac cauaauuauc uuaacucccu gccucccggc     1560

guguucucuc accucaccgc ccugcggggc cugagccuua auuccaacag acugacaguc     1620

cucucucaua augaccugcc cgcuaaccuc gagauccugg acauuagccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuucc cucagcgugc uggacaucac gcacaauaaa     1740

uucauuugug aaugcgagcu gucuaccuuu aucaacuggc uuaaucacac aaacgucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acuccuucag cggagucucu     1860

cuguuuuccc ucagcacaga aggcugcgau gaggaggaag ugcugaaguc ucucaaguuc     1920

agccuguucu uuguuuguac cgugacgcuu acacuguucc ucaugaccau ucugaccguc     1980

acaaaauuuc ggggguucug cuuuaucugc uauaagaccg cccagagacu gguguucaaa     2040

gaccauccuc aaggaacaga gcccgauaug uacaaguaug acgccuaccu uuguuuuucc     2100

agcaaagauu ucacgugggu ucagaaugcu cugcucaagc accuggacac ccaguauucu     2160

gaucagaacc gcuuuaaccu cugcuucgag gaacgggacu uugugccggg cgaaaauaga     2220

aucgccaaca uucaagaugc gaucuggaac ucccgcaaga uugucugucu ggugagccgg     2280

cauuuccuua gagacgggug gugccuggag gcuuucuccu acgcccaggg ccgcugucug     2340

ucugaccuca auagcgcccu gaucauggug guugucggau cccuuucuca guaucagcug     2400

augaaacacc aaagcauucg gggcuuugug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acguggggug guuccuccac aaacuguccc agcagauccu uaagaaagaa     2520

aaggagaaga aaaaggauaa uaacaucccc cugcaaacag ucgcuaccau uucuuga        2577


<210>  9655
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS89

<400>  9655

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Thr Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9656
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17472

<400>  9656
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuac caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaauuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucguucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9657
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17472

<400>  9657
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucac caacgccauc uccaagagcc aggccuucuc ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cagcuccguc cggcaccucg accugagcca cggguucgug      900

uucucccuga acagccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccugu ccuacaaccu gcugggggag cucuacagcu ccaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagacguuc     1140

aaguuccucg agaagcugca gacccuggac cuccgggaca acgcccugac caccauccac     1200

uucaucccca gcaucccgga caucuuccug uccgggaaca agcucgucac gcugcccaag     1260

aucaaccuga ccgcgaaccu cauccaccug agcgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

uccagcugcu ccggcgacca gacccccagc gagaacccgu cccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacagccu cccgcccggc     1560

guguucuccc accugacggc ccugcggggg cucagccuga acuccaaccg ccugaccgug     1620

cucagccaca acgaccugcc cgccaaccug gagauccucg acaucucccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugagc cucuccgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ucaaccacac gaacgugacc     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acuccuucag cggggucucc     1860

cuguucagcc uguccaccga gggcugcgac gaggaggagg ugcucaagag ccugaaguuc     1920

ucccuguucu ucgugugcac cgucacgcuc acccuguucc ugaugaccau ccucaccgug     1980

acgaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac gcaguacagc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac agccgcaaga ucgugugccu ggucucccgg     2280

cacuuccugc gcgacgggug gugccucgag gccuucagcu acgcccaggg ccggugccug     2340

uccgaccuga acagcgcgcu caucauggug guggucgggu cccugagcca guaccagcug     2400

augaagcacc aguccauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acgugggcug guuccugcac aagcucagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg ucgccaccau cuccuga        2577


<210>  9658
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17472

<400>  9658
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucac caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucaacuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acuccuucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9659
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17472

<400>  9659
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuac aaacgcuauc agcaagaguc aagcauucuc ucucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

accuuugccg gcuuagcgcg guccagcguu cgccaucugg accuaucgca cgguuucgug      900

uuuucucuca acucccgagu cuucgagacg cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucugu cauauaacuu gcucggagaa cuguacagua gcaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucagga ucagacuuuc     1140

aaauuucuag agaagcucca gacccuggac cuuagagaua augcuuugac aacuauacac     1200

uucaucccau ccauuccgga caucuuucug ucuggcaaca aacucguuac ccugcccaag     1260

auaaauuuaa cagccaaccu gauucaccuu agcgaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

ucaaguuguu ccggggacca gaccccaagc gaaaaccccu cuuuggagca gcuguucuua     1440

ggagaaaaua ugcuccaacu ggcgugggag acggagcuuu gcugggaugu auuugaaggu     1500

cugucacacc uccagguguu guaccugaac cauaauuauc uaaacagucu gccuccaggc     1560

gucuucagcc accucacugc ccugcgcggg cuuuccuuga acucuaauag acugacagug     1620

uuaucgcaua augaccuccc cgcaaaccug gagauccuug acauuagcag gaaucagcug     1680

cuagcuccga acccugaugu uuuugugucc cucucagucc uggacauaac ccacaauaaa     1740

uucaucugug aaugcgaguu gaguacuuuu auuaacuggc ugaaucacac aaacgugacc     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acucuuucag cggcguuucc     1860

uuauuuucac ucagcacgga agguugcgau gaggaggaag ugcugaaguc ucuuaaguuc     1920

ucccuguucu uugucuguac cgugacauug acucucuucc ugaugaccau ucuaacaguc     1980

acuaaauuuc ggggguucug cuuuauaugc uauaagaccg cccagcgacu gguguucaaa     2040

gaccaucccc aaggcacaga gccagauaug uacaaguaug acgcauaccu uuguuuuagu     2100

agcaaagauu ucaccugggu ucagaaugcc cuccugaagc acuuggacac ucaguauucu     2160

gaucagaacc gcuuuaaccu gugcuucgaa gagagagacu uugugcccgg agaaaauagg     2220

aucgcuaaca uucaagaugc gaucuggaac ucccggaaga uuguauguuu agucucacgc     2280

cauuuccuca gagacggcug gugccuggag gcauucaguu acgcccaggg gaggugucuu     2340

agcgaccuga acucggcuuu gaucauggug guugugggau cccucucuca guaucagcug     2400

augaaacacc aaagcauacg ugguuuuguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acgugggcug guuccuucac aaacucucac agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaauauucca uugcaaacgg uagccacaau caguuga        2577


<210>  9660
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17472

<400>  9660
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucac caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucaacuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagcuucag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9661
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17472

<400>  9661
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuac caacgcuauc ucuaagagcc aagccuucuc ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

acauuugcug gccucgccag aagcucuguc cggcaucugg accuuuccca cggcuucgug      900

uuuagccuga acucucgcgu guucgagacc cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucuca gcuauaaccu gcuuggagag cuguacuccu cuaauuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagacauuc     1140

aaauuucugg agaagcugca gacccucgac cugagagaua augcccugac gacaauucac     1200

uucaucccca gcaucccuga cauuuuucuc uccgggaaca aacuggugac ccuucccaag     1260

aucaaucuga cagcuaaccu cauucaccug agcgaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

ucuuccugua gcggagacca gaccccuucu gaaaaccccu cccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcaacu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugagccacc uucagguucu cuaccugaac cauaauuauc uuaacucccu gccucccgga     1560

guguucucuc accucacagc ccugcggggc cugagccuua auuccaacag acugacgguc     1620

cucucucaua augaccugcc cgcuaaccuc gagauccugg acauuagccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuucc cucagcgugc uggacaucac ccacaauaaa     1740

uucauuugug aaugcgagcu gucuacauuu aucaacuggc uuaaucacac caacgucaca     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acuccuucag cggcgucucu     1860

cuguuuuccc ucagcaccga aggaugcgau gaggaggaag ugcugaaguc ucucaaguuc     1920

agccuguucu uuguuuguac ggugacacuu acccuguucc ucaugaccau ucugacaguc     1980

accaaauuuc ggggcuucug cuuuaucugc uauaagacag cccagagacu gguguucaaa     2040

gaccauccuc aagggacgga gcccgauaug uacaaguaug acgccuaccu uuguuuuucc     2100

agcaaagauu ucaccugggu ucagaaugcu cugcucaagc accuggacac acaguauucu     2160

gaucagaacc gcuuuaaccu cugcuucgag gaacgggacu uugugccggg agaaaauaga     2220

aucgccaaca uucaagaugc gaucuggaac ucccgcaaga uugucugucu ggugagccgg     2280

cauuuccuua gagacggcug gugccuggag gcuuucuccu acgcccaggg gcgcugucug     2340

ucugaccuca auagcgcccu gaucauggug guugucggcu cccuuucuca guaucagcug     2400

augaaacacc aaagcauucg gggauuugug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acgugggcug guuccuccac aaacuguccc agcagauccu uaagaaagaa     2520

aaggagaaga aaaaggauaa uaacaucccc cugcaaaccg ucgcuacaau uucuuga        2577


<210>  9662
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__D1CS90

<400>  9662

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Ser 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Phe Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  9663
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR5__Homo_sapiens__AAZ17473

<400>  9663
augggagacc accuggaccu ucuccuagga guggugcuca uggccggucc uguguuugga       60

auuccuuccu gcuccuuuga uggccgaaua gccuuuuauc guuucugcaa ccucacccag      120

gucccccagg uccucaacac cacugagagg cuccugcuga gcuucaacua uaucaggaca      180

gucacugcuu cauccuuccc cuuucuggaa cagcugcagc ugcuggagcu cgggagccag      240

uauacccccu ugacuauuga caaggaggcc uucagaaacc ugcccaaccu uagaaucuug      300

gaccugggaa guaguaagau auacuucuug cauccagaug cuuuucaggg acuguuccau      360

cuguuugaac uuagacugua uuucuguggu cucucugaug cuguauugaa agaugguuau      420

uucagaaauu uaaaggcuuu aacucgcuug gaucuaucca aaaaucagau ucguagccuu      480

uaccuucauc cuucauuugg gaaguugaau uccuuaaagu ccauagauuu uuccuccaac      540

caaauauucc uuguauguga acaugagcuc gagccccuac aagggaaaac gcucuccuuu      600

uuuagccucg cagcuaauag cuuguauagc agagucucag uggacugggg aaaauguaug      660

aacccauuca gaaacauggu gcuggagaua cuagauguuu cuggaaaugg cuggacagug      720

gacaucacag gaaacuuuag caaugccauc agcaaaagcc aggccuucuc uuugauucuu      780

gcccaccaca ucaugggugc cggguuuggc uuccauaaca ucaaagaucc ugaccagaac      840

acauuugcug gccuggccag aaguucagug agacaccugg aucuuucaca uggguuuguc      900

uucucccuga acucacgagu cuuugagaca cucaaggauu ugaagguucu gaaccuugcc      960

uacaacaaga uaaauaagau ugcagaugaa gcauuuuacg gacuugacaa ccuccaaguu     1020

cucaauuugu cauauaaccu ucugggggaa cuuuacaguu cgaauuucua uggacuaccu     1080

aagguagccu acauugauuu gcaaaagaau cacauugcaa uaauucaaga ccaaacauuc     1140

aaauuccugg aaaaauuaca gaccuuggau cuccgagaca augcucuuac aaccauucau     1200

uuuauuccaa gcauacccga uaucuucuug aguggcaaua aacuagugac uuugccaaag     1260

aucaaccuua cagcgaaccu cauccacuua ucagaaaaca ggcuagaaaa ucuagauauu     1320

cucuacuuuc uccuacgggu accucaucuc cagauucuca uuuuaaauca aaaucgcuuc     1380

uccuccugua guggagauca aaccccuuca gagaauccca gcuuagaaca gcuuuuccuu     1440

ggagaaaaua uguugcaacu ugccugggaa acugagcucu guugggaugu uuuugaggga     1500

cuuucucauc uucaaguucu guauuugaau cauaacuauc uuaauucccu uccaccagga     1560

guauuuagcc aucugacugc auuaagggga cuaagccuca acuccaacag gcugacaguu     1620

cuuucucaca augauuuacc ugcuaauuua gagauccugg acauauccag gaaccagcuc     1680

cuagcuccua auccugaugu auuuguauca cuuagugucu uggauauaac ucauaacaag     1740

uucauuugug aaugugaacu uagcacuuuu aucaguuggc uuaaucacac caaugucacu     1800

auagcugggc cuccugcaga cauauauugu guguacccug acucguucuc ugggguuucc     1860

cucuucucuc uuuccacgga agguugugau gaagaggaag ucuuaaaguc ccuaaaguuc     1920

ucccuuuucu uuguaugcac ugucacucug acucuguucc ucaugaccau ccucacaguc     1980

acaaaguucc ggggcuucug uuuuaucugu uauaagacag cccagagacu gguguucaag     2040

gaccaucccc agggcacaga accugauaug uacaaauaug augccuauuu gugcuucagc     2100

agcaaagacu ucacaugggu gcagaaugcu uugcucaaac accuggacac ucaauacagu     2160

gaccaaaaca gauucaaccu gugcuuugaa gaaagagacu uugucccagg agaaaaccgc     2220

auugccaaua uccaggaugc caucuggaac aguagaaaga ucguuugucu ugugagcaga     2280

cacuuccuua gagauggcug gugccuugaa gccuucaguu augcccaggg caggugcuua     2340

ucugaccuua acagugcucu caucauggug gugguugggu ccuuguccca guaccaguug     2400

augaaacauc aauccaucag aggcuuugua cagaaacagc aguauuugag guggccugag     2460

gaucuccagg auguuggcug guuucuucau aaacucucuc aacagauacu aaagaaagaa     2520

aaagaaaaga agaaagacaa uaacauuccg uugcaaacug uagcaaccau cuccuaa        2577


<210>  9664
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR5__Homo_sapiens__AAZ17473

<400>  9664
augggcgacc accuggaccu ccugcugggg gugguccuca uggccggccc cguguucggg       60

aucccgagcu gcuccuucga cggccgcauc gccuucuacc gguucugcaa ccugacccag      120

gugccccagg uccugaacac cacggagcgc cuccugcuga gcuucaacua cauccggacc      180

gugaccgcgu ccagcuuccc cuuccucgag cagcugcagc ugcucgagcu ggggucccag      240

uacacgcccc ugaccaucga caaggaggcc uuccgcaacc ucccgaaccu gcggauccug      300

gaccucggca gcuccaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cucuucgagc ugcgccugua cuucugcggg cucagcgacg ccgugcugaa ggacggcuac      420

uuccggaacc ugaaggcccu cacccgccug gaccugucca agaaccagau ccggagccuc      480

uaccugcacc ccuccuucgg gaagcugaac agccucaagu ccaucgacuu cagcuccaac      540

cagaucuucc uggucugcga gcacgagcug gagccccucc agggcaagac ccugagcuuc      600

uucucccugg cggccaacag ccucuacucc cgcgugagcg uggacugggg gaagugcaug      660

aacccguucc ggaacauggu ccuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucacgg ggaacuucuc caacgccauc agcaaguccc aggccuucag ccucauccug      780

gcgcaccaca ucaugggcgc cggguucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggcccg cuccagcguc cggcaccucg accuguccca cggguucgug      900

uucagccuga acucccgcgu guucgagacc cucaaggacc ugaagguccu gaaccuggcc      960

uacaacaaga ucaacaagau cgcggacgag gccuucuacg gccucgacaa ccuccaggug     1020

cugaaccuga gcuacaaccu gcugggggag cucuacucca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcugca gacgcuggac cuccgggaca acgcccugac caccauccac     1200

uucauccccu ccaucccgga caucuuccug agcgggaaca agcucgucac ccugcccaag     1260

aucaaccuga cggcgaaccu cauccaccug uccgagaacc gccuggagaa ccucgacauc     1320

cuguacuucc ugcuccgggu gccccaccuc cagauccuga uccugaacca gaaccgcuuc     1380

agcuccugca gcggcgacca gacccccucc gagaacccga gccuggagca gcuguuccuc     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcucu gcugggacgu guucgagggg     1500

cugagccacc uccagguccu guaccugaac cacaacuacc ugaacucccu cccgcccggc     1560

guguucagcc accugaccgc ccugcggggg cucucccuga acagcaaccg ccugacggug     1620

cucucccaca acgaccugcc cgccaaccug gagauccucg acaucagccg gaaccagcug     1680

cuggccccca accccgacgu cuucgugucc cucagcgucc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu guccaccuuc aucagcuggc ucaaccacac caacgugacg     1800

aucgcgggcc cgcccgccga caucuacugc guguaccccg acuccuucag cggggucucc     1860

cuguucagcc uguccaccga gggcugcgac gaggaggagg ugcucaagag ccugaaguuc     1920

ucccuguucu ucgugugcac cgucacccuc acgcuguucc ugaugaccau ccucaccgug     1980

accaaguucc gcggcuucug cuucaucugc uacaagacgg cccagcgccu gguguucaag     2040

gaccaccccc aggggaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu ccagaacgcc cuccugaagc accuggacac ccaguacucc     2160

gaccagaacc gguucaaccu cugcuucgag gagcgcgacu ucgugcccgg cgagaaccgg     2220

aucgcgaaca uccaggacgc caucuggaac agccgcaaga ucgugugccu ggucucccgg     2280

cacuuccugc gcgacgggug gugccucgag gccuucagcu acgcccaggg ccggugccug     2340

uccgaccuga acagcgcgcu caucauggug guggucgggu cccugagcca guaccagcug     2400

augaagcacc aguccauccg cggcuucgug cagaagcagc aguaccuccg guggccggag     2460

gaccugcagg acgugggcug guuccugcac aagcucagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagacgg ucgccaccau cuccuga        2577


<210>  9665
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR5__Homo_sapiens__AAZ17473

<400>  9665
augggcgacc accucgaccu ccuccucggc gucguccuca uggccggccc cgucuucggc       60

auccccuccu gcuccuucga cggccgcauc gccuucuacc gcuucugcaa ccucacccag      120

gucccccagg uccucaacac caccgagcgc cuccuccucu ccuucaacua cauccgcacc      180

gucaccgccu ccuccuuccc cuuccucgag cagcuccagc uccucgagcu cggcucccag      240

uacacccccc ucaccaucga caaggaggcc uuccgcaacc uccccaaccu ccgcauccuc      300

gaccucggcu ccuccaagau cuacuuccuc caccccgacg ccuuccaggg ccucuuccac      360

cucuucgagc uccgccucua cuucugcggc cucuccgacg ccguccucaa ggacggcuac      420

uuccgcaacc ucaaggcccu cacccgccuc gaccucucca agaaccagau ccgcucccuc      480

uaccuccacc ccuccuucgg caagcucaac ucccucaagu ccaucgacuu cuccuccaac      540

cagaucuucc ucgucugcga gcacgagcuc gagccccucc agggcaagac ccucuccuuc      600

uucucccucg ccgccaacuc ccucuacucc cgcgucuccg ucgacugggg caagugcaug      660

aaccccuucc gcaacauggu ccucgagauc cucgacgucu ccggcaacgg cuggaccguc      720

gacaucaccg gcaacuucuc caacgccauc uccaaguccc aggccuucuc ccucauccuc      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccucgcccg cuccuccguc cgccaccucg accucuccca cggcuucguc      900

uucucccuca acucccgcgu cuucgagacc cucaaggacc ucaagguccu caaccucgcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccucgacaa ccuccagguc     1020

cucaaccucu ccuacaaccu ccucggcgag cucuacuccu ccaacuucua cggccucccc     1080

aaggucgccu acaucgaccu ccagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccucg agaagcucca gacccucgac cuccgcgaca acgcccucac caccauccac     1200

uucauccccu ccauccccga caucuuccuc uccggcaaca agcucgucac ccuccccaag     1260

aucaaccuca ccgccaaccu cauccaccuc uccgagaacc gccucgagaa ccucgacauc     1320

cucuacuucc uccuccgcgu cccccaccuc cagauccuca uccucaacca gaaccgcuuc     1380

uccuccugcu ccggcgacca gacccccucc gagaaccccu cccucgagca gcucuuccuc     1440

ggcgagaaca ugcuccagcu cgccugggag accgagcucu gcugggacgu cuucgagggc     1500

cucucccacc uccagguccu cuaccucaac cacaacuacc ucaacucccu cccccccggc     1560

gucuucuccc accucaccgc ccuccgcggc cucucccuca acuccaaccg ccucaccguc     1620

cucucccaca acgaccuccc cgccaaccuc gagauccucg acaucucccg caaccagcuc     1680

cucgccccca accccgacgu cuucgucucc cucuccgucc ucgacaucac ccacaacaag     1740

uucaucugcg agugcgagcu cuccaccuuc aucuccuggc ucaaccacac caacgucacc     1800

aucgccggcc cccccgccga caucuacugc gucuaccccg acuccuucuc cggcgucucc     1860

cucuucuccc ucuccaccga gggcugcgac gaggaggagg uccucaaguc ccucaaguuc     1920

ucccucuucu ucgucugcac cgucacccuc acccucuucc ucaugaccau ccucaccguc     1980

accaaguucc gcggcuucug cuucaucugc uacaagaccg cccagcgccu cgucuucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu cugcuucucc     2100

uccaaggacu ucaccugggu ccagaacgcc cuccucaagc accucgacac ccaguacucc     2160

gaccagaacc gcuucaaccu cugcuucgag gagcgcgacu ucguccccgg cgagaaccgc     2220

aucgccaaca uccaggacgc caucuggaac ucccgcaaga ucgucugccu cgucucccgc     2280

cacuuccucc gcgacggcug gugccucgag gccuucuccu acgcccaggg ccgcugccuc     2340

uccgaccuca acuccgcccu caucaugguc gucgucggcu cccucuccca guaccagcuc     2400

augaagcacc aguccauccg cggcuucguc cagaagcagc aguaccuccg cuggcccgag     2460

gaccuccagg acgucggcug guuccuccac aagcucuccc agcagauccu caagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cuccagaccg ucgccaccau cuccuga        2577


<210>  9666
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR5__Homo_sapiens__AAZ17473

<400>  9666
augggcgacc accuggaucu ccuucugggg guggucuuga uggccggacc cguuuucggu       60

aucccuagcu gcuccuuuga cggcagaauu gcuuucuaca gguuuuguaa cuuaacccag      120

gugccacaag uacugaauac aacugagcgg cuacuccugu cuuucaacua uauacgcacg      180

gugaccgcau caaguuuucc guuccuugaa cagcugcagu ugcucgagcu ggggagccag      240

uacacacccc ugacuaucga uaaggaagcc uuucgaaauc ucccuaacuu acguauucug      300

gaccuuggau ccucuaaaau cuauuucuug cauccagaug cguuucaagg ccuguuccac      360

cuauuugagc ucagacugua cuucugcggu cuuucggacg cuguccugaa ggauggguau      420

uuuaggaauu ugaaagcccu cacccggcug gacuuaucaa agaaccagau ucgcagccug      480

uaccuccauc ccaguuucgg aaaacuuaau ucccugaagu cuaucgauuu cagcuccaac      540

cagauauuuu ugguguguga acacgagcua gagccucugc agggcaagac acucucauuc      600

uuuagucugg cagccaauag ccuuuauucu agaguuuccg uggacugggg caaaugcaug      660

aacccauuca ggaauauggu ccuggaaauc uuggaugugu cagggaacgg auggaccgua      720

gacauuacug guaauuuuag caacgcuauc aguaagucuc aagcauucuc ccucauucug      780

gcccaucaca ucaugggcgc uggguuugga uuccacaaua uaaaagaucc cgaccagaac      840

acauuugccg gcuuagcgcg gagcucgguu cgccaucugg accuaucuca cgguuucgug      900

uuuucccuca acucacgagu cuucgagacc cugaaggauc uuaaaguguu gaaucuggca      960

uacaacaaga uuaauaagau cgccgacgag gcuuuuuacg ggcucgauaa ccugcaagug     1020

cuuaaucuga guuauaacuu gcucggagaa cuguacagcu ccaauuucua uggcuuaccu     1080

aaagucgccu acauugaccu gcagaagaac cauaucgcaa ucauucagga ucagacguuc     1140

aaauuucuag agaagcucca gacucuggac cuuagagaua augcuuugac cacaauacac     1200

uucaucccau cuauuccgga caucuuucug agcggcaaca aacucguuac ucugcccaag     1260

auaaauuuaa ccgccaaccu gauucaccuu ucagaaaaua gguuggagaa ccucgauauc     1320

cuguauuucc uacugcgggu gccucaucuc caaauccuga uucuuaauca gaaccguuuu     1380

aguuccugua gcggggacca gacaccaucu gaaaaccccu cauuggagca gcuguucuua     1440

ggagaaaaua ugcuccaacu ggcgugggag accgagcuuu gcugggaugu auuugaaggu     1500

cugagucacc uccagguguu guaccugaac cauaauuauc uaaacagccu gccuccaggc     1560

gucuucuccc accucacggc ccugcgcggg cuuucuuuga acucgaauag acugacugug     1620

uuaagccaua augaccuccc cgcaaaccug gagauccuug acauuuccag gaaucagcug     1680

cuagcuccga acccugaugu uuuuguguca cucagugucc uggacauaac acacaauaaa     1740

uucaucugug aaugcgaguu gucuaccuuu auuagcuggc ugaaccacac uaaugugaca     1800

aucgccggac ccccagcuga uaucuacugu guauacccug acuccuucuc aggcguuagc     1860

uuauuuucuc ucuccaccga agguugcgau gaggaggaag ugcugaagag ucuuaaguuc     1920

agccuguucu uugucuguac ggugaccuug acacucuucc ugaugacuau ucuaaccguc     1980

acaaaauuuc ggggguucug cuuuauaugc uauaagacug cccagcgacu gguguucaaa     2040

gaccaucccc aaggcaccga gccagauaug uacaaguaug acgcauaccu uuguuuuucu     2100

uccaaagauu ucacaugggu ucagaacgcc cuccugaagc acuuggacac ccaguauuca     2160

gaucagaauc gcuuuaaccu gugcuucgaa gagagagacu uugugcccgg agaaaacagg     2220

aucgcuaaua uucaagaugc gaucuggaac agucggaaga uuguauguuu agucagccgc     2280

cauuuccuca gagacggcug gugccuggag gcauucucgu acgcccaggg gaggugucuu     2340

uccgaccuga acucugcuuu gaucauggug guugugggaa gccucucaca guaucagcug     2400

augaaacacc aaaguauacg ugguuuuguc cagaagcagc aauaccuacg guggccugag     2460

gaucugcagg acgugggcug guuccuucac aaacucuccc agcagauccu gaagaaagaa     2520

aaggagaaga aaaaggauaa uaauauucca uugcaaacug uagccacgau cucuuga        2577


<210>  9667
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR5__Homo_sapiens__AAZ17473

<400>  9667
augggcgacc accuggaccu gcugcugggc guggugcuga uggccggccc cguguucggc       60

auccccagcu gcagcuucga cggcagaauc gccuucuaca gauucugcaa ccugacccag      120

gugccccagg ugcugaacac caccgagaga cugcugcuga gcuucaacua caucagaacc      180

gugaccgcca gcagcuuccc cuuccuggag cagcugcagc ugcuggagcu gggcagccag      240

uacacccccc ugaccaucga caaggaggcc uucagaaacc ugcccaaccu gagaauccug      300

gaccugggca gcagcaagau cuacuuccug caccccgacg ccuuccaggg ccuguuccac      360

cuguucgagc ugagacugua cuucugcggc cugagcgacg ccgugcugaa ggacggcuac      420

uucagaaacc ugaaggcccu gaccagacug gaccugagca agaaccagau cagaagccug      480

uaccugcacc ccagcuucgg caagcugaac agccugaaga gcaucgacuu cagcagcaac      540

cagaucuucc uggugugcga gcacgagcug gagccccugc agggcaagac ccugagcuuc      600

uucagccugg ccgccaacag ccuguacagc agagugagcg uggacugggg caagugcaug      660

aaccccuuca gaaacauggu gcuggagauc cuggacguga gcggcaacgg cuggaccgug      720

gacaucaccg gcaacuucag caacgccauc agcaagagcc aggccuucag ccugauccug      780

gcccaccaca ucaugggcgc cggcuucggc uuccacaaca ucaaggaccc cgaccagaac      840

accuucgccg gccuggccag aagcagcgug agacaccugg accugagcca cggcuucgug      900

uucagccuga acagcagagu guucgagacc cugaaggacc ugaaggugcu gaaccuggcc      960

uacaacaaga ucaacaagau cgccgacgag gccuucuacg gccuggacaa ccugcaggug     1020

cugaaccuga gcuacaaccu gcugggcgag cuguacagca gcaacuucua cggccugccc     1080

aagguggccu acaucgaccu gcagaagaac cacaucgcca ucauccagga ccagaccuuc     1140

aaguuccugg agaagcugca gacccuggac cugagagaca acgcccugac caccauccac     1200

uucaucccca gcauccccga caucuuccug agcggcaaca agcuggugac ccugcccaag     1260

aucaaccuga ccgccaaccu gauccaccug agcgagaaca gacuggagaa ccuggacauc     1320

cuguacuucc ugcugagagu gccccaccug cagauccuga uccugaacca gaacagauuc     1380

agcagcugca gcggcgacca gacccccagc gagaacccca gccuggagca gcuguuccug     1440

ggcgagaaca ugcugcagcu ggccugggag accgagcugu gcugggacgu guucgagggc     1500

cugagccacc ugcaggugcu guaccugaac cacaacuacc ugaacagccu gccccccggc     1560

guguucagcc accugaccgc ccugagaggc cugagccuga acagcaacag acugaccgug     1620

cugagccaca acgaccugcc cgccaaccug gagauccugg acaucagcag aaaccagcug     1680

cuggccccca accccgacgu guucgugagc cugagcgugc uggacaucac ccacaacaag     1740

uucaucugcg agugcgagcu gagcaccuuc aucagcuggc ugaaccacac caacgugacc     1800

aucgccggcc cccccgccga caucuacugc guguaccccg acagcuucag cggcgugagc     1860

cuguucagcc ugagcaccga gggcugcgac gaggaggagg ugcugaagag ccugaaguuc     1920

agccuguucu ucgugugcac cgugacccug acccuguucc ugaugaccau ccugaccgug     1980

accaaguuca gaggcuucug cuucaucugc uacaagaccg cccagagacu gguguucaag     2040

gaccaccccc agggcaccga gcccgacaug uacaaguacg acgccuaccu gugcuucagc     2100

agcaaggacu ucaccugggu gcagaacgcc cugcugaagc accuggacac ccaguacagc     2160

gaccagaaca gauucaaccu gugcuucgag gagagagacu ucgugcccgg cgagaacaga     2220

aucgccaaca uccaggacgc caucuggaac agcagaaaga ucgugugccu ggugagcaga     2280

cacuuccuga gagacggcug gugccuggag gccuucagcu acgcccaggg cagaugccug     2340

agcgaccuga acagcgcccu gaucauggug guggugggca gccugagcca guaccagcug     2400

augaagcacc agagcaucag aggcuucgug cagaagcagc aguaccugag auggcccgag     2460

gaccugcagg acgugggcug guuccugcac aagcugagcc agcagauccu gaagaaggag     2520

aaggagaaga agaaggacaa caacaucccc cugcagaccg uggccaccau cagcuga        2577


<210>  9668
<211>  2577
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR5__Homo_sapiens__AAZ17473

<400>  9668
augggcgacc accuggaucu ccugcuuggg gugguccuga uggccggacc cguuuucggc       60

aucccuagcu gcuccuuuga cgggagaauu gcuuucuacc gguuuuguaa ccucacccag      120

gugccgcaag ugcugaauac aacggagcgc cuucugcucu cuuucaacua uaucagaacc      180

gucacagcca gcuccuuucc cuuccuggaa cagcugcagc uccuggagcu uggaucucag      240

uacaccccuc ugacaauuga uaaggaagcg uuucggaauc uccccaaccu gcgcauccuu      300

gaccugggca gcuccaaaau uuauuuccuc cauccugaug cuuuucaagg gcuguuccac      360

cuguuugagc ucagacugua cuucugcgga cuuucugacg ccgugcugaa ggauggcuau      420

uuucggaauc ucaaagcccu gacccgccuu gaccugagca agaaccagau cagaucccuc      480

uaccugcauc ccagcuucgg caaacucaau ucucucaagu ccaucgauuu cagcucuaac      540

cagauuuuuc ugguuuguga acacgagcuu gagccucugc aggggaagac acucuccuuc      600

uuuagccugg cugccaauuc ucuuuauucc cgggugagcg ucgacugggg aaaaugcaug      660

aacccguucc gcaauauggu gcuggaaauc cucgauguuu ccggcaacgg guggaccgug      720

gacauuacgg gaaauuuuuc uaacgcuauc agcaaguccc aagccuucag ccugauucug      780

gcgcaucaca ucaugggcgc cggguuugga uuccacaaua uuaaagaucc cgaccagaac      840

accuuugcug gccucgccag aucuuccguc cggcaucugg accuuagcca cggcuucgug      900

uuuucucuga acagccgcgu guucgagaca cucaaggauc ugaaaguccu gaaucuugcu      960

uacaacaaga ucaauaagau cgccgacgaa gcguuuuacg ggcucgauaa ccugcagguu     1020

cugaaucucu ccuauaaccu gcuuggagag cuguacucua gcaauuucua uggccucccu     1080

aaaguggccu acauugaccu gcagaagaac cauaucgcua uuauccaaga ucagaccuuc     1140

aaauuucugg agaagcugca gacacucgac cugagagaua augcccugac cacgauucac     1200

uucauccccu ccaucccuga cauuuuucuc agcgggaaca aacuggugac acuucccaag     1260

aucaaucuga ccgcuaaccu cauucaccug ucugaaaauc ggcuggagaa ccuugauauc     1320

cucuauuucc ugcugcgcgu cccgcaucuc caaauucuga uccuuaauca gaacagauuu     1380

uccagcuguu cuggagacca gacaccuucc gaaaacccca gccuggagca gcuguuccug     1440

ggcgaaaaua ugcugcaacu ugccugggag accgagcucu gcugggaugu guuugaaggg     1500

cugucccacc uucagguucu cuaccugaac cauaauuauc uuaacucucu gccucccgga     1560

guguucagcc accucaccgc ccugcggggc cugucccuua auucuaacag acugacaguc     1620

cucagccaua augaccugcc cgcuaaccuc gagauccugg acauuucccg caaucagcuu     1680

cuggcgccua acccggaugu guuuguuagc cucucugugc uggacaucac gcacaauaaa     1740

uucauuugug aaugcgagcu guccaccuuu aucagcuggc uuaaccacac aaaugucacc     1800

auugccgggc ccccugcuga uaucuacugu guguaccccg acucuuucuc cggcgucagc     1860

cuguuuucuc ucagcacaga aggaugcgau gaggaggaag ugcugaaguc ccucaaguuc     1920

agccuguucu uuguuuguac cgugacgcuu acacuguucc ucaugaccau ucugaccguc     1980

acaaaauuuc ggggcuucug cuuuaucugc uauaagaccg cccagagacu gguguucaaa     2040

gaccauccuc aagggacaga gcccgauaug uacaaguaug acgccuaccu uuguuuuucu     2100

uccaaagauu ucacgugggu ucagaacgcu cugcucaagc accuggacac ccaguauagc     2160

gaucagaauc gcuuuaaccu cugcuucgag gaacgggacu uugugccggg agaaaacaga     2220

aucgccaaua uucaagaugc gaucuggaac ucccgcaaga uugucugucu ggugucucgg     2280

cauuuccuua gagacggcug gugccuggag gcuuucagcu acgcccaggg gcgcugucug     2340

uccgaccuca auucugcccu gaucauggug guugucggca gccuuuccca guaucagcug     2400

augaaacacc aaucuauucg gggauuugug cagaagcagc aauaccucag auggccugag     2460

gaucugcagg acgugggcug guuccuccac aaacugagcc agcagauccu uaagaaagaa     2520

aaggagaaga aaaaggauaa caauaucccc cugcaaacag ucgcuaccau uuccuga        2577


<210>  9669
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__B6CH37

<400>  9669

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Leu Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9670
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__ABW37065

<400>  9670
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcguuccuaa acaagucuua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9671
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__ABW37065

<400>  9671
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcgugcccaa gcagguccuc aagcuggagg cccugcagga gcucaacgug     1440

gcguucaacu cccugaccga ccugcccggg ugcggcagcu ucuccagccu cagcgugcug     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcucgagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccugaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccuccu gaucgucacc aucggggcca ccaugcuggu gcucgccgug     1800

accgucacgu cccugugcau cuaccuggac cuccccuggu accugcggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcucca gcgcaaccug     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc ucgagaagga ggacauccag aucugccugc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccugu uccacgaggg gagcaacaac cugauccuca uccugcugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ugaugaccca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccucuucu gggcgaacau ccgggccgcc     2340

uucaacauga agcugacgcu ggugaccgag aacaacgacg ucaagagcug a              2391


<210>  9672
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__ABW37065

<400>  9672
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccguccccaa gcagguccuc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9673
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__ABW37065

<400>  9673
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggaaaauga gaccgaauca cuucaaauac ugaacgcuaa aacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga gugugccaaa acagguacuc aagcuggagg cacuacagga acugaauguu     1440

gccuuuaacu cccucaccga ccugcccgga ugcggcagcu ucucuucacu uaguguguug     1500

aucaucgauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uuaaggccgg cgauaaccca uuucagugca caugcgagcu gcgcgaguuc     1620

gugaagaaca uagaccaggu cuccucagaa guguuagagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccucucaagg acuuucacau guccgagcug     1740

ucaugcaaua ucacucuucu gauuguuacc aucggugcga caauguuggu gcucgcagua     1800

accgucacua gccuguguau uuaucuagau cugcccuggu accucagaau ggugugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac aucccacugg aggaacuuca gagaaauuug     1920

caguuccacg cuuuuauauc uuauuccgag caugacagug ccuggguuaa aagcgaacug     1980

gugccuuacu uagagaagga agauauccaa auuugucucc acgagaggaa cuucgucccc     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauagaaa aguccuauaa gucaauuuuu     2100

guacugaguc caaauuucgu gcagagcgag uggugucauu acgaacuuua cuuugcacac     2160

cacaaccugu uccaugaggg gucgaauaac cuaauccuca uucuguugga acccaucccu     2220

cagaauagua uaccaaacaa auaucacaag cugaaggcuu uaaugaccca gcggacuuac     2280

cuccaauggc cgaaggagaa aucuaagcga ggacuguucu gggccaauau ccgcgcggcc     2340

uuuaacauga aacuuacccu gguuacagag aauaacgacg ucaagagcug a              2391


<210>  9674
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__ABW37065

<400>  9674
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcgugcccaa gcaggugcug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9675
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__ABW37065

<400>  9675
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccgucccuaa acaggugcuu aagcucgagg cccugcagga acugaauguc     1440

gcguuuaaca gccucaccga ccugcccggc ugcgggucuu ucuccagccu uuccgugcug     1500

auuaucgauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaaa     1560

augagaagca uuaaggcugg agauaacccc uuucagugca caugcgagcu ccgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcuggagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcuu     1740

uccugcaaua ucacccuccu gauuguuaca aucggagcca cgaugcuggu gcucgcuguc     1800

accgugacaa gccuguguau uuaucuugau cugcccuggu accucagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac aucccucugg aagaacugca gagaaaucuu     1920

caguuccacg cguuuauuuc uuauagcgag caugacuccg ccuggguuaa aagcgaacug     1980

guccccuacc ucgagaagga agauauccaa aucugucugc acgagcgcaa cuucgugccu     2040

ggcaaaucua uuguggagaa uaucauuaac ugcaucgaaa aguccuauaa gagcauuuuu     2100

guccucuccc ccaauuucgu gcagucugag uggugucauu acgaacugua cuuugcucac     2160

cacaaccuuu uccaugaggg gagcaauaac cugauccuca uccugcugga accgauuccu     2220

cagaauagca uccccaacaa auaucacaaa cuuaaggccc ugaugaccca gcggacguac     2280

cuccaauggc cuaaggagaa aucuaagaga ggacuguucu gggcuaauau ucgcgccgcc     2340

uuuaacauga aacucacccu gguuacagag aauaacgacg ucaagagcug a              2391


<210>  9676
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__B6CH42

<400>  9676

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Thr Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9677
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__ABW37070

<400>  9677
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauacgucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcguuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9678
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__ABW37070

<400>  9678
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucagcgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaccucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacgcugcac      600

cuggucuucc accccaccuc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacgcg cggccccacc cugcugaacu ucacccucaa ccacaucgag      780

accacgugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac caucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccacgc ugaaggcgcu gaccaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacacggu guucagcgag augaacauca ugaugcugac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acgcagaacg ucuucaccga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugacgaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcaccugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcgugcccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu cagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu gagcuccgag guccuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgugacc aucggggcca ccaugcuggu gcuggccguc     1800

acggugaccu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggucaa guccgagcug     1980

gugccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaccca gcgcacguac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggucaccgag aacaacgacg ugaaguccug a              2391


<210>  9679
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__ABW37070

<400>  9679
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaccucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccguccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9680
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__ABW37070

<400>  9680
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacacguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaaccgug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gacagaauca cuucaaauac ugaacgcuaa gacuuugcau      600

cuagucuucc acccaaccag ucuguuugcc auucagguga auaucagcgu aaacacacuc      660

gggugucugc agcuuaccaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucacuag aggacccaca cuguuaaacu uuacccugaa ccauaucgaa      780

acgacuugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac cauaaucgag uccauucggg aagaggacuu cacauauuca      900

aagacuaccu ugaaagcacu gacaaucgaa cacauaacca aucagguguu ucucuucagc      960

cagacggccc uguacacugu cuuuagugag augaacauua ugaugcuuac aaucucugau     1020

acccccuuca uccacaugcu gugcccucau gcuccaucca cuuuuaaguu cuugaauuuu     1080

acacaaaacg uuuucaccga cagcauuuuu gaaaaguguu cgacgcucgu gaaacuggag     1140

accuuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugacaaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacuugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

accgacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga gugugccaaa acagguaguu aagcucgagg cacugcagga acuaaaugug     1440

gccuuuaacu cccugacaga ccuccccgga ugcggcagcu ucucuucacu gaguguccuu     1500

aucaucgauc acaauagcgu gucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uuaaggccgg cgauaaccca uuucagugca cuugcgaguu gcgcgaguuc     1620

gucaagaaca uagaccaggu guccucagaa guucuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua ucacccugcu uauugugaca aucggugcga ccaugcuggu auuggcaguc     1800

acugugacga gccucuguau uuaucuggau cuacccuggu accugagaau gguuugccaa     1860

uggacacaga ccaggcggcg ugcccgcaac aucccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuauauc uuauuccgag caugacagug ccugggugaa aagcgaauug     1980

gucccuuacc uggagaagga agauauccaa auuuguuuac acgagaggaa cuucgugccc     2040

ggcaaaucua ucguagagaa uauuaucaac ugcauagaaa aguccuauaa gucaauuuuu     2100

gugcucaguc caaauuucgu ucagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauccuaa uucuccugga acccaucccu     2220

cagaauagca uaccaaacaa auaucacaag uugaaagcuc ugaugacuca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ccgcgcggcc     2340

uuuaacauga aacugacacu ugucaccgag aauaacgacg ucaagagcug a              2391


<210>  9681
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__ABW37070

<400>  9681
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaccagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcgugcccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9682
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__ABW37070

<400>  9682
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaccagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuacaguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gaccgaaucc cugcaaauuc ucaacgccaa aacacugcac      600

cuuguguucc acccuaccag ccuguuugcc auccagguua auaucucugu gaacacacuc      660

ggaugucugc agcuuaccaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugacgag aggccccacc cugcucaacu uuacacugaa ccauauugaa      780

accacaugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac cauuaucgag agcauccgcg aagaggacuu cacguauucc      900

aagacaaccc ugaaagcucu uacaauugaa cacaucacca aucagguuuu ucucuucucu      960

cagaccgccc uguacacagu guuuagcgag augaacauua ugaugcugac gaucuccgau     1020

acccccuuca uucacaugcu cugcccucau gcucccagca cauuuaaguu ccugaauuuu     1080

acccaaaacg uguucacaga cucuaucuuu gaaaaguguu ccacccuugu caaacuggag     1140

acgcucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacaaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcaccugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccgucccuaa acaggugguc aaacuugagg cccuccagga acugaaugug     1440

gcguuuaaca gccugacaga ccuccccggc ugcgggucuu ucuccagccu guccguucuu     1500

auuaucgauc acaauucugu gagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca uuaaggcugg agauaacccc uuucagugua ccugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu guccagcgaa guucucgagg gcuggcccga cucuuacaaa     1680

ugcgauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua ucacacuucu cauugugacg aucggagcca ccaugcuggu ccuggcugug     1800

acagugacca gccucuguau uuaucuggau cuucccuggu accugagaau gguuugccaa     1860

uggacacaga cccggcgcag agcccggaac aucccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuauuuc uuauagcgag caugacuccg ccugggucaa aagcgaacuu     1980

gugcccuacc uggagaagga agauauccaa aucugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua uugucgagaa uaucauuaac ugcaucgaaa aguccuauaa gagcauuuuu     2100

gugcuguccc ccaauuucgu ucagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uccuccugga accgauuccu     2220

cagaauagca uccccaacaa auaucacaag cugaaagccc uuaugacgca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ucgcgccgcc     2340

uuuaacauga aacugacacu cgugaccgag aauaacgacg ucaagagcug a              2391


<210>  9683
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__B6CH44

<400>  9683

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Thr Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9684
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__ABW37072

<400>  9684
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuacu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9685
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__ABW37072

<400>  9685
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccacc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacgcugcac      600

cuggucuucc accccaccuc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacgcg cggccccacc cugcugaacu ucacccucaa ccacaucgag      780

accacgugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac caucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccacgc ugaaggcgcu gaccaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacacggu guucagcgag augaacauca ugaugcugac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acgcagaacg ucuucaccga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugacgaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcaccugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

acggucaccu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaccca gcgcacguac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugaccgag aacaacgacg ucaagagcug a              2391


<210>  9686
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__ABW37072

<400>  9686
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccacc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9687
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__ABW37072

<400>  9687
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgacc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc caucugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuauugc gcaccuccac cuguccuaca ucuuacugga ccuccguaac      540

uauuacauua aggagaauga gacagaauca cuucaaaucc ugaacgcuaa gacuuugcau      600

cuagucuucc acccaaccag ucuguuugcc auacagguga auauuagcgu aaacacacuc      660

gggugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu uuucauuaaa      720

uucuugucug agcucacuag aggacccaca cuguuaaacu uuacccugaa ccauaucgaa      780

acgacuugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauaucu acaaccuuac cauuauagag uccauccggg aagaggacuu cacauauuca      900

aagacuaccu ugaaagcacu gacaauugaa cacaucacca aucagguguu ucucuucagc      960

cagacggccc uguacacugu cuuuagugag augaacauaa ugaugcuuac aauuucugau     1020

acccccuuca uccacaugcu gugcccucau gcuccaucca cuuuuaaguu cuugaauuuu     1080

acacaaaacg uuuucaccga cagcaucuuu gaaaaguguu cgacgcucgu gaaacuggag     1140

accuuaauuc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugacaaaa     1200

gacaugccgu cucuugagau cuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacuugggu cgaaagcauu gugguucuca accuguccuc uaauauguua     1320

accgacagcg uguucagaug ucugcccccu aggauaaagg uccuugauuu gcauucaaac     1380

aaaaucaaga guauuccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugacaga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

aucaucgauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uuaaggccgg cgauaaccca uuucagugca cuugcgaguu gcgcgaguuc     1620

gugaagaaca uagaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua ucacccugcu uauuguuaca aucggugcga ccaugcuggu guuggcagua     1800

acugucacga gccucuguau uuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacacaga ccaggcggcg ugcccgcaac aucccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuauauc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauccaa auuuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauagaaa aguccuauaa gucaauuuuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauccuaa uucuccugga acccaucccu     2220

cagaauagca uaccaaacaa auaucacaag uugaaagcuc ugaugacuca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ccgcgcggcc     2340

uuuaacauga aacugacacu uguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9688
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__ABW37072

<400>  9688
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccacc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9689
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__ABW37072

<400>  9689
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccaca      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uaucugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccauugc ucaucugcac cuuucuuaca uccugcucga ccugcgcaac      540

uauuacauua aggagaauga gaccgaaucc cugcaaaucc ucaacgccaa aacacugcac      600

cuuguguucc acccuaccag ccuguuugcc auucagguua auaucucugu gaacacacuc      660

ggaugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu cuucauuaaa      720

uuccucuccg agcugacgag aggccccacc cugcucaacu uuacacugaa ccauaucgaa      780

accacaugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauauuu acaaccugac caucauugag agcauccgcg aagaggacuu cacguauucc      900

aagacaaccc ugaaagcucu uacaaucgaa cacauuacca aucagguuuu ucucuucucu      960

cagaccgccc uguacacagu guuuagcgag augaacauca ugaugcugac gauuuccgau     1020

acccccuuca uccacaugcu cugcccucau gcucccagca cauuuaaguu ccugaauuuu     1080

acccaaaacg uguucacaga cucuauuuuu gaaaaguguu ccacccuugu caaacuggag     1140

acgcucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacaaaa     1200

gacaugccua gccuggagau ccuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcaccugggu ggaaucuauu gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcaucaagg ugcuggaucu gcauucuaac     1380

aaaauuaagu ccaucccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugacaga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

auuaucgauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca uuaaggcugg agauaacccc uuucagugua ccugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugcgauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua ucacacuucu cauuguuacg aucggagcca ccaugcuggu gcuggcuguc     1800

acagugacca gccucuguau uuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacacaga cccggcgcag agcccggaac aucccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuauuuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauccaa aucugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua uuguggagaa uaucauuaac ugcaucgaaa aguccuauaa gagcauuuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uccuccugga accgauuccu     2220

cagaauagca uccccaacaa auaucacaag cugaaagccc uuaugacgca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ucgcgccgcc     2340

uuuaacauga aacugacacu cguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9690
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__B6CH45

<400>  9690

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Thr Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Met Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9691
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__ABW37073

<400>  9691
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuacu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccau guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcguuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9692
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__ABW37073

<400>  9692
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccacc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacgcugcac      600

cuggucuucc accccaccuc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacgcg cggccccacc cugcugaacu ucacccucaa ccacaucgag      780

accacgugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac caucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccacgc ugaaggcgcu gaccaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacacgau guucagcgag augaacauca ugaugcugac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acgcagaacg uguucaccga cuccaucuuc gagaagugca gcacccuggu caagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugacgaag     1200

gacaugccgu cccucgagau ccuggacgug agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcaccugggu cgaguccauc guggugcuca accugagcuc caacaugcug     1320

accgacagcg ucuuccgcug ccucccgccc cggaucaagg ugcuggaccu gcacuccaac     1380

aagaucaaga gcguccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

acggucaccu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaccca gcgcacguac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugaccgag aacaacgacg ucaagagcug a              2391


<210>  9693
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__ABW37073

<400>  9693
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccacc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccau guucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccguccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9694
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__ABW37073

<400>  9694
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgacc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc caucugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuauugc gcaccuccac cuguccuaca ucuuacugga ccuccguaac      540

uauuacauua aggagaauga gacagaauca cuucaaaucc ugaacgcuaa gacuuugcau      600

cuagucuucc acccaaccag ucuguuugcc auacagguga auauuagcgu aaacacacuc      660

gggugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu uuucauuaaa      720

uucuugucug agcucacuag aggacccaca cuguuaaacu uuacccugaa ccauaucgaa      780

acgacuugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauaucu acaaccuuac cauuauagag uccauccggg aagaggacuu cacauauuca      900

aagacuaccu ugaaagcacu gacaauugaa cacaucacca aucagguguu ucucuucagc      960

cagacggccc uguacacuau guuuagugag augaacauaa ugaugcuuac aauuucugau     1020

acccccuuca uccacaugcu gugcccucau gcuccaucca cuuuuaaguu cuugaauuuu     1080

acacaaaacg ucuucaccga cagcaucuuu gaaaaguguu cgacgcucgu uaaacuggag     1140

accuuaauuc ugcagaagaa uggccuaaaa gaucucuuca aggugggucu gaugacaaaa     1200

gacaugccgu cucuugagau cuuggaugua uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacuugggu ggaaagcauu gucgugcuca accuguccuc uaauauguua     1320

accgacagcg uuuucagaug ucugcccccu aggauaaagg ugcuugauuu gcauucaaac     1380

aaaaucaaga gugucccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugacaga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

auuaucgauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca ucaaggccgg cgauaaccca uuucagugca cuugcgaguu gcgcgaguuc     1620

gugaagaaca uugaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uaacccugcu uaucguuaca auuggugcga ccaugcuggu guuggcagua     1800

acugucacga gccucuguau cuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacacaga ccaggcggcg ugcccgcaac auuccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauacaa aucuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua uuguggagaa uaucauuaac ugcaucgaaa aguccuauaa gucaauauuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauuccu     2220

cagaauagca ucccaaacaa auaucacaag uugaaagcuc ugaugacuca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau acgcgcggcc     2340

uuuaacauga aacugacacu uguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9695
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__ABW37073

<400>  9695
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccacc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccau guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcgugcccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9696
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__ABW37073

<400>  9696
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccaca      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uaucugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccauugc ucaucugcac cuuucuuaca uccugcucga ccugcgcaac      540

uauuacauua aggagaauga gaccgaaucc cugcaaaucc ucaacgccaa aacacugcac      600

cuuguguucc acccuaccag ccuguuugcc auucagguua auaucucugu gaacacacuc      660

ggaugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu cuucauuaaa      720

uuccucuccg agcugacgag aggccccacc cugcucaacu uuacacugaa ccauaucgaa      780

accacaugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauauuu acaaccugac caucauugag agcauccgcg aagaggacuu cacguauucc      900

aagacaaccc ugaaagcucu uacaaucgaa cacauuacca aucagguuuu ucucuucucu      960

cagaccgccc uguacacaau guuuagcgag augaacauca ugaugcugac gauuuccgau     1020

acccccuuca uccacaugcu cugcccucau gcucccagca cauuuaaguu ccugaauuuu     1080

acccaaaacg uguucacaga cucuauuuuu gaaaaguguu ccacccuugu gaaacuggag     1140

acgcucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggucggacu caugacaaaa     1200

gacaugccua gccuggagau ccuggaugug ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcaccugggu ugaaucuauu gugguccuga accuuagcuc caauaugcug     1320

accgacagcg uguuccggug ucuucccccg cgcaucaagg uucuggaucu gcauucuaac     1380

aaaauuaagu ccgugccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugacaga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

aucauugauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggcugg agauaacccc uuucagugua ccugcgagcu gcgggaguuc     1620

gugaagaaca uugaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugcgauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua ucacacuucu caucguuacg auuggagcca ccaugcuggu gcuggcuguc     1800

acagugacca gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacacaga cccggcgcag agcccggaac auuccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauucaa aucugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauucuga uccuccugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaag cugaaagccc uuaugacgca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacugacacu cguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9697
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__B6RFS7

<400>  9697

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Leu Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9698
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__ABY67116

<400>  9698
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucuua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9699
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__ABY67116

<400>  9699
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucagcgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcagguccuc aagcuggagg cccugcagga gcucaacgug     1440

gcguucaacu cccugaccga ccugcccggg ugcggcagcu ucuccagccu cagcgugcug     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cagcuccgag gugcucgagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccugaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccuccu gaucgugacc aucggggcca ccaugcuggu ccucgccgug     1800

accgugacgu cccugugcau cuaccuggac cuccccuggu accugcggau ggucugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcucca gcgcaaccug     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gugccguacc ucgagaagga ggacauccag aucugccugc acgagcggaa cuucgucccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccugu uccacgaggg gagcaacaac cugauccuca uccugcugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ugaugaccca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccucuucu gggcgaacau ccgggccgcc     2340

uucaacauga agcugacgcu ggugaccgag aacaacgacg ugaaguccug a              2391


<210>  9700
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__ABY67116

<400>  9700
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcagguccuc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9701
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__ABY67116

<400>  9701
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggaaaauga gaccgaauca cuucaaauac ugaacgcuaa aacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acaggugcuc aagcuggagg cacuacagga acugaaugua     1440

gccuuuaacu cccucaccga ccugcccgga ugcggcagcu ucucuucacu uaguguuuug     1500

aucauugauc acaauagcgu gucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggccgg cgauaaccca uuucagugca caugcgagcu gcgcgaguuc     1620

gucaagaaca ucgaccaggu guccucagaa gucuuagagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccucucaagg acuuucacau guccgagcug     1740

ucaugcaaua uuacucuucu gaucgugacc auuggugcga caauguuggu ucucgcagug     1800

accguaacua gccuguguau cuaucuagau cugcccuggu accucagaau ggucugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccacugg aggaacuuca gagaaauuug     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccugggugaa aagcgaacug     1980

guuccuuacu uagagaagga agauauucaa aucugucucc acgagaggaa cuucgugccc     2040

ggcaaaucua uugucgagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

gugcugaguc caaauuucgu acagagcgag uggugucauu acgaacuuua cuuugcacac     2160

cacaaccugu uccaugaggg gucgaauaac cuaauucuca uccuguugga acccauaccu     2220

cagaauagua ucccaaacaa auaucacaag cugaaggcuu uaaugaccca gcggacuuac     2280

cuccaauggc cgaaggagaa aucuaagcga ggacuguucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacuuacccu ggugacagag aauaacgacg uuaagagcug a              2391


<210>  9702
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__ABY67116

<400>  9702
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcaggugcug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9703
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__ABY67116

<400>  9703
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acagguccuu aagcucgagg cccugcagga acugaaugug     1440

gcguuuaaca gccucaccga ccugcccggc ugcgggucuu ucuccagccu uuccguccug     1500

aucauugauc acaauucugu gagccauccu uccgccgacu uuuuccaauc uugucagaaa     1560

augagaagca ucaaggcugg agauaacccc uuucagugca caugcgagcu ccgggaguuc     1620

guuaagaaca ucgaccaggu guccagcgaa guccuggagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcuu     1740

uccugcaaua uuacccuccu gaucgugaca auuggagcca cgaugcuggu ucucgcugug     1800

accgucacaa gccuguguau cuaucuugau cugcccuggu accucagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccucugg aagaacugca gagaaaucuu     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccugggugaa aagcgaacug     1980

guucccuacc ucgagaagga agauauccaa auuugucugc acgagcgcaa cuucgucccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

gugcucuccc ccaauuucgu ccagucugag uggugucauu acgaacugua cuuugcucac     2160

cacaaccuuu uccaugaggg gagcaauaac cugauccuca uucugcugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaaa cuuaaggccc ugaugaccca gcggacguac     2280

cuccaauggc cuaaggagaa aucuaagaga ggacuguucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacucacccu ggugacagag aauaacgacg uuaagagcug a              2391


<210>  9704
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS91

<400>  9704

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Ala Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9705
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88753

<400>  9705
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggc ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9706
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88753

<400>  9706
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucagcgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggc cgaguccauc guggugcuca accugagcuc caacaugcug     1320

accgacagcg ucuuccgcug ccucccgccc cggaucaagg ugcuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cgcugcagga gcugaacgug     1440

gccuucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcguccuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgugacc aucggggcca ccaugcuggu ccuggcggug     1800

accgugacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggucugccag     1860

uggacccaga cccgccggcg cgcccggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gugccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgucccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu ccaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggcgc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggccaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugacggag aacaacgacg ugaaguccug a              2391


<210>  9707
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88753

<400>  9707
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggc cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9708
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88753

<400>  9708
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggc agaaagcaua gucgugcuca accuguccuc uaauauguua     1320

acugacagcg uuuucagaug ucugcccccu aggaucaagg ugcuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acaggucgug aagcucgagg cccugcagga acuaaaugua     1440

gcuuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gaguguucuu     1500

aucauugauc acaauagcgu gucccauccu ucugccgacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggcggg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gucaagaaca ucgaccaggu guccucagaa guccuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uuacucugcu uaucgugacc auuggugcaa caaugcuggu uuuggccgug     1800

accguaacua gccucuguau cuaucuggau cuacccuggu accugagaau ggucugccaa     1860

uggacgcaga caaggcggcg ugcucgcaac auaccacucg aagaacugca gagaaaucuu     1920

caguuccacg ccuuuaucuc uuauuccgag caugacagug caugggugaa aagcgaauug     1980

guuccuuacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgugccc     2040

ggcaaaucua uugucgagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

gugcucaguc caaauuucgu acagagcgag uggugucauu acgaacugua cuuugcucac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauaccu     2220

cagaauagua ucccaaacaa auaucacaag uugaaagccc ugaugaugca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggcgaauau ucgcgccgca     2340

uuuaacauga aacugacucu ugugaccgag aauaacgacg uuaagagcug a              2391


<210>  9709
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88753

<400>  9709
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggc cgagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9710
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88753

<400>  9710
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggc cgaaucuauc gugguccuga accuuagcuc caauaugcug     1320

accgacagcg uguuccggug ucuucccccg cgcauuaagg uucuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acaggugguc aaacuugagg cgcuccagga acugaaugug     1440

gccuuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccguccuu     1500

aucauugauc acaauucugu gagccauccu uccgcugacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggccgg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

guuaagaaca ucgaccaggu guccagcgaa guccucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua uuacccuucu caucgugaca auuggagcua cgaugcuggu ucuggccgug     1800

accgucacaa gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcgcggaac auuccucucg aagaacugca gagaaaucug     1920

caguuccacg ccuuuaucuc uuauagcgag caugacuccg cuugggugaa aagcgaacuu     1980

guucccuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgucccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

gugcuguccc ccaauuucgu ccagucugag uggugucauu acgaacucua cuuugcccac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uucuccugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaag cugaaagcuc uuaugaugca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggccaauau ccgcgccgcu     2340

uuuaacauga aacugacgcu cgugaccgag aauaacgacg uuaagagcug a              2391


<210>  9711
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS92

<400>  9711

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Thr Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9712
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88754

<400>  9712
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugacgca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9713
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88754

<400>  9713
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

accgucacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaccca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacgcu ggugaccgag aacaacgacg ucaagagcug a              2391


<210>  9714
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88754

<400>  9714
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaccca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9715
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88754

<400>  9715
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

aucauugauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggccgg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gugaagaaca ucgaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uuacucugcu uaucguuacc auuggugcga caaugcuggu guuggcagua     1800

accgucacua gccucuguau cuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua uuguggagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauaccu     2220

cagaauagua ucccaaacaa auaucacaag uugaaagcuc ugaugaccca gcggacuuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacugacccu uguuacagag aauaacgacg ucaagagcug a              2391


<210>  9716
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88754

<400>  9716
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaccca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9717
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88754

<400>  9717
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

aucauugauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggcugg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua uuacccuucu caucguuaca auuggagcca cgaugcuggu gcuggcuguc     1800

accgugacaa gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uucuccugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaag cugaaagccc uuaugaccca gcggacguac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacugacccu cguuacagag aauaacgacg ucaagagcug a              2391


<210>  9718
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS93

<400>  9718

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9719
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88755

<400>  9719
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9720
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88755

<400>  9720
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

accgucacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugacggag aacaacgacg ucaagagcug a              2391


<210>  9721
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88755

<400>  9721
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9722
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88755

<400>  9722
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

aucauugauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggccgg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gugaagaaca ucgaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uuacucugcu uaucguuacc auuggugcga caaugcuggu guuggcagua     1800

accgucacua gccucuguau cuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua uuguggagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauaccu     2220

cagaauagua ucccaaacaa auaucacaag uugaaagcuc ugaugaugca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacugacucu uguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9723
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88755

<400>  9723
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9724
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88755

<400>  9724
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

aucauugauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggcugg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua uuacccuucu caucguuaca auuggagcca cgaugcuggu gcuggcuguc     1800

accgugacaa gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uucuccugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaag cugaaagccc uuaugaugca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacugacgcu cguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9725
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS96

<400>  9725

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Leu Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9726
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88758

<400>  9726
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucua     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9727
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88758

<400>  9727
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

accgucacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccauccug     2220

cagaacucca ucccgaacaa guaccacaag cucaaggccc ugaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccucuucu gggcgaacau ccgggccgcc     2340

uucaacauga agcugacccu ggugacggag aacaacgacg ucaagagcug a              2391


<210>  9728
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88758

<400>  9728
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccauccuc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9729
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88758

<400>  9729
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggaaaauga gaccgaauca cuucaaauac ugaacgcuaa aacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

aucauugauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggccgg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gugaagaaca ucgaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uuacucugcu uaucguuacc auuggugcga caaugcuggu guuggcagua     1800

accgucacua gccucuguau cuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccacucg aggaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua uuguggagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauauug     2220

cagaauagua ucccuaacaa auaucacaag cugaaggcuu uaaugaugca gcggaccuac     2280

cuccaauggc caaaggagaa aucuaagcga ggacuguucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacuuacucu gguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9730
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88758

<400>  9730
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccauccug     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9731
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88758

<400>  9731
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggaaaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

aucauugauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggcugg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua uuacccuucu caucguuaca auuggagcca cgaugcuggu gcuggcuguc     1800

accgugacaa gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccucucg aggaacugca gagaaaucug     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uucuccugga accgauccug     2220

cagaauagca uuccuaacaa auaucacaaa cuuaaggccc ugaugaugca gcggaccuac     2280

cuccaauggc ccaaggagaa aucuaagaga ggacuguucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacucacgcu gguuaccgag aauaacgacg ucaagagcug a              2391


<210>  9732
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS97

<400>  9732

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Val Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9733
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88759

<400>  9733
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcguuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9734
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88759

<400>  9734
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucagcgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcgugcccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu cagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu gagcuccgag guccuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgugacc aucggggcca ccaugcuggu gcuggccguc     1800

accgugacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggucaa guccgagcug     1980

gugccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggucacggag aacaacgacg ugaaguccug a              2391


<210>  9735
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88759

<400>  9735
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccguccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9736
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88759

<400>  9736
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucgugggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacggu cuuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cagcauuuuu gaaaaguguu cgacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu cgaaagcaua gugguucuca accuguccuc uaauauguua     1320

acugacagcg uguucagaug ucugcccccu aggaucaagg uccuugauuu gcauucaaac     1380

aaaauuaaga gugugccaaa acagguaguu aagcucgagg cacugcagga acuaaaugug     1440

gccuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gaguguccuu     1500

aucaucgauc acaauagcgu gucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uuaaggccgg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gucaagaaca uagaccaggu guccucagaa guucuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua ucacucugcu uauugugacc aucggugcga caaugcuggu auuggcaguc     1800

accgugacua gccucuguau uuaucuggau cuacccuggu accugagaau gguuugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac aucccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuauauc uuauuccgag caugacagug ccugggugaa aagcgaauug     1980

gucccuuacc uggagaagga agauauccaa auuuguuuac acgagaggaa cuucgugccc     2040

ggcaaaucua ucguagagaa uauuaucaac ugcauagaaa aguccuauaa gucaauuuuu     2100

gugcucaguc caaauuucgu ucagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauccuaa uucuccugga acccaucccu     2220

cagaauagua uaccaaacaa auaucacaag uugaaagcuc ugaugaugca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ccgcgcggcc     2340

uuuaacauga aacugacucu ugucaccgag aauaacgacg uuaagagcug a              2391


<210>  9737
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88759

<400>  9737
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcgugcccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9738
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88759

<400>  9738
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccgu guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ggaaucuauc gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcauuaagg ugcuggaucu gcauucuaac     1380

aaaaucaagu ccgucccuaa acaggugguc aaacuugagg cccuccagga acugaaugug     1440

gcguuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccguucuu     1500

auuaucgauc acaauucugu gagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca uuaaggcugg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu guccagcgaa guucucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua ucacccuucu cauugugaca aucggagcca cgaugcuggu ccuggcugug     1800

accgugacaa gccucuguau uuaucuggau cuucccuggu accugagaau gguuugccaa     1860

uggacccaga cacggcgcag agcccggaac aucccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuauuuc uuauagcgag caugacuccg ccugggucaa aagcgaacuu     1980

gugcccuacc uggagaagga agauauccaa aucugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua uugucgagaa uaucauuaac ugcaucgaaa aguccuauaa gagcauuuuu     2100

gugcuguccc ccaauuucgu ucagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uccuccugga accgauuccu     2220

cagaauagca uccccaacaa auaucacaag cugaaagccc uuaugaugca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ucgcgccgcc     2340

uuuaacauga aacugacgcu cgugaccgag aauaacgacg ucaagagcug a              2391


<210>  9739
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS98

<400>  9739

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Ser Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9740
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88760

<400>  9740
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguucaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acccagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaagaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9741
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88760

<400>  9741
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggcagcacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacucc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucagc      960

cagaccgccc uguacaccgu guucuccgag augaacauca ugaugcugac gaucagcgac     1020

accccguuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccugaacuuc     1080

acccagaacg ucuucacgga cagcaucuuc gagaagugcu ccacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccca gccucgagau ccuggacguc uccuggaaca gccuggaguc cggccggcac     1260

aaggagaacu gcacgugggu ggagagcauc gugguccuca accuguccag caacaugcug     1320

accgacuccg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacagcaac     1380

aagaucaagu ccauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaaca gccucaccga ccugcccggg ugcggcuccu ucagcagccu guccgugcuc     1500

aucaucgacc acaacagcgu gucccacccg agcgccgacu ucuuccaguc cugccagaag     1560

augcgcagca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu guccagcgag gugcuggagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgagagcua ccgcggcucc ccgcucaagg acuuccacau gagcgagcug     1740

uccugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

accgucacga gccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacagcgag cacgacuccg ccugggucaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccg     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccuguccc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg guccaacaac cugauccuga uccuccugga gcccaucccc     2220

cagaacagca ucccgaacaa guaccacaag cugaaggccc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugacggag aacaacgacg ucaagagcug a              2391


<210>  9742
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88760

<400>  9742
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggcuccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9743
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88760

<400>  9743
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ucuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggauccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggcccaaacc uguggaguau      840

cugaauauuu acaaccuuac uauaaucgag ucaauucggg aagaggacuu caccuauagc      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagu      960

cagaccgccc uguacacggu cuuuucugag augaacauua ugaugcuuac uaucuccgau     1020

acaccauuca uccacaugcu gugcccccau gcuccuagca ccuuuaaguu cuugaauuuu     1080

acucaaaacg uuuucacaga cucgauuuuu gaaaaguguu cuacccucgu gaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugaccaaa     1200

gacaugccau cccuugagau uuuggaugug ucauggaaca gucuggaaag cgggcgccac     1260

aaggagaauu gcacaugggu cgaauccaua gugguucuca accugucuag caauauguua     1320

acugacucag uguucagaug ucugccgccc aggaucaagg uccuugauuu gcauaguaac     1380

aaaauuaagu ccaucccuaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaaca gccugaccga ccucccagga ugcggcucuu ucucaagucu gagcgugcuu     1500

aucauugauc acaauuccgu cucucauccc ucggcugacu uuuuccaaag cugucagaaa     1560

augcggucca uaaaggccgg cgauaacccu uuucagugca caugcgaguu gcgcgaguuc     1620

gugaagaaca ucgaccaggu cucaagugaa gugcuggagg gguggccaga cucuuacaaa     1680

ugugauuauc ccgaaagcua ccgaggaucc ccguuaaagg acuuucacau gucagagcuc     1740

agcugcaaua uuacucugcu uaucguuacc auuggugcga caaugcuggu guuggcagua     1800

accgucacuu cucucuguau cuaucuggau cuaccuuggu accugagaau ggugugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccccucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc cuauagugag caugacagcg ccuggguuaa aucugaauug     1980

gugccauacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgucccu     2040

ggcaaaucca uuguggagaa uaucauaaac ugcauugaaa agucauauaa gaguaucuuu     2100

guacucagcc ccaauuucgu gcagucggag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg guccaauaac cugauucuaa uccuccugga accaauaccc     2220

cagaauagua ucccuaacaa auaucacaag uugaaagcuc ugaugaugca gcggaccuac     2280

uuacaauggc caaaggagaa aagcaagcga ggacucuucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacugacucu uguuaccgag aauaacgacg ucaagucaug a              2391


<210>  9744
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88760

<400>  9744
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggcagcacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9745
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88760

<400>  9745
augaccaagg acaaagagcc caucgugaag ucuuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cuggaucugc uccccaucgc ucaccuucac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcau      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggcagcacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggcccaaacc ugucgaguau      840

cucaauaucu acaaccugac aauuaucgag uccauccgcg aagaggacuu caccuauucu      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucagc      960

cagaccgccc uguacaccgu guuuuccgag augaacauua ugaugcugac aaucagcgau     1020

acgccguuca uucacaugcu cugcccccau gcuccuucua ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cuccaucuuu gaaaagugua gcacacuugu caaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacgaaa     1200

gacaugcccu cucuggagau ucuggauguu agcuggaacu cccucgaauc uggcagacac     1260

aaggagaauu gcacaugggu ggaaagcauc gucgugcuga accuuuccag caauaugcug     1320

accgacucug uuuuccggug ucucccuccc cgcauuaagg ugcuggaucu gcauuccaac     1380

aaaaucaaga gcauuccgaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaacu cucugaccga ccucccuggc ugcggguccu ucagcucccu gucugugcuu     1500

aucauugauc acaauagcgu uucccauccc ucugccgacu uuuuccaaag cugucagaag     1560

augagaucca ucaaggcugg agauaacccu uuucagugca caugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cagcucugaa gugcucgagg gcuggcccga cuccuacaaa     1680

ugugauuauc ccgaaagcua ccgcgggucu ccucugaagg acuuucacau guccgagcug     1740

agcugcaaua uuacccuucu caucguuaca auuggagcca cgaugcuggu gcuggcuguc     1800

accgugacau cucucuguau cuaucuggau cuuccguggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccccucg aagaacugca gagaaaucug     1920

caguuccacg cguuuaucag cuauuccgag caugacagcg ccuggguuaa aucugaacuu     1980

gucccuuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgugccc     2040

ggcaaaucca ucguggagaa uauuaucaac ugcauugaaa agagcuauaa guccaucuuu     2100

guccugucuc cuaauuucgu gcagagcgag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg guccaauaac cuuauccuga uucuccugga acccaucccg     2220

cagaauagca uuccuaacaa auaucacaag cugaaagccc uuaugaugca gcggaccuac     2280

cugcaauggc ccaaggagaa aagcaagaga ggacucuucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacugacgcu cguuaccgag aauaacgacg ugaaguccug a              2391


<210>  9746
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CS99

<400>  9746

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Ile Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Met Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9747
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88761

<400>  9747
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuauu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccau guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9748
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88761

<400>  9748
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucagcgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccauc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacccugcac      600

cuggucuucc accccacguc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacccg cggccccacg cugcugaacu ucacccucaa ccacaucgag      780

accaccugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac gaucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccaccc ugaaggcgcu gacgaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacaccau guucagcgag augaacauca ugaugcugac gaucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucacgga cuccaucuuc gagaagugca gcacccuggu caagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugaccaag     1200

gacaugccgu cccucgagau ccuggacgug agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcacgugggu cgaguccauc guggugcuca accugagcuc caacaugcug     1320

accgacagcg ucuuccgcug ccucccgccc cggaucaagg ugcuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcguccuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgugacc aucggggcca ccaugcuggu ccuggccgug     1800

accgugacgu cccucugcau cuaccuggac cugcccuggu accuccggau ggucugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gugccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgucccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu ccaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacccu ggugacggag aacaacgacg ugaaguccug a              2391


<210>  9749
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88761

<400>  9749
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccauc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccau guucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9750
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88761

<400>  9750
augaccaagg acaaagagcc caucgucaag agcuuccacu uugugugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgauc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc cauuugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuaucgc gcaccuccac cuguccuaca uuuuacugga ccuccguaac      540

uauuacauca aggagaauga gaccgaauca cuucaaauac ugaacgcuaa gacauugcau      600

cuagucuucc acccaacuuc ccuguuugcc auucagguga auaucagcgu aaacacccuc      660

gggugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu uuucaucaaa      720

uucuugucug agcucaccag aggacccacu cuguuaaacu uuacacugaa ccauaucgaa      780

accacgugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauauuu acaaccuuac uauaaucgag uccauucggg aagaggacuu caccuauuca      900

aagacaacuu ugaaagcacu gaccaucgaa cacauaacaa aucagguguu ucucuucagc      960

cagaccgccc uguacacgau guuuagugag augaacauua ugaugcuuac uaucucugau     1020

acacccuuca uccacaugcu gugcccucau gcuccaucca ccuuuaaguu cuugaauuuu     1080

acucaaaacg ucuucacaga cagcauuuuu gaaaaguguu cgacccucgu uaaacuggag     1140

acguuaaucc ugcagaagaa uggccuaaaa gaucucuuca aggugggucu gaugaccaaa     1200

gacaugccgu cucuugagau uuuggaugua uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacaugggu ggaaagcaua gucgugcuca accuguccuc uaauauguua     1320

acugacagcg uuuucagaug ucugcccccu aggaucaagg ugcuugauuu gcauucaaac     1380

aaaauuaaga guaucccaaa acaggucgug aagcucgagg cacugcagga acuaaaugua     1440

gccuuuaacu cccugaccga ccuccccgga ugcggcagcu ucucuucacu gaguguucuu     1500

aucauugauc acaauagcgu gucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uaaaggccgg cgauaaccca uuucagugca caugcgaguu gcgcgaguuc     1620

gucaagaaca ucgaccaggu guccucagaa guccuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua uuacucugcu uaucgugacc auuggugcga caaugcuggu uuuggcagug     1800

accguaacua gccucuguau cuaucuggau cuacccuggu accugagaau ggucugccaa     1860

uggacgcaga caaggcggcg ugcccgcaac auaccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuaucuc uuauuccgag caugacagug ccugggugaa aagcgaauug     1980

guuccuuacc uggagaagga agauauucaa aucuguuuac acgagaggaa cuucgugccc     2040

ggcaaaucua uugucgagaa uaucauaaac ugcauugaaa aguccuauaa gucaaucuuu     2100

gugcucaguc caaauuucgu acagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauucuaa uccuccugga acccauaccu     2220

cagaauagua ucccaaacaa auaucacaag uugaaagcuc ugaugaugca gcggaccuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ucgcgcggcc     2340

uuuaacauga aacugacucu ugugaccgag aauaacgacg uuaagagcug a              2391


<210>  9751
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88761

<400>  9751
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccauc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccau guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9752
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88761

<400>  9752
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccauc      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uauuugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccaucgc ucaucugcac cuuucuuaca uucugcucga ccugcgcaac      540

uauuacauca aggagaauga gacagaaucc cugcaaauuc ucaacgccaa aacccugcac      600

cuuguguucc acccuacaag ccuguuugcc auccagguua auaucucugu gaacacccuc      660

ggaugucugc agcuuacaaa uauuaagcug aacgaugaca auugccaggu cuucaucaaa      720

uuccucuccg agcugaccag aggccccacg cugcucaacu uuacccugaa ccauauugaa      780

acaaccugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauaucu acaaccugac aauuaucgag agcauccgcg aagaggacuu caccuauucc      900

aagacgacac ugaaagcucu uaccauugaa cacaucacaa aucagguuuu ucucuucucu      960

cagaccgccc uguacaccau guuuagcgag augaacauua ugaugcugac aaucuccgau     1020

acgcccuuca uucacaugcu cugcccucau gcucccagca ccuuuaaguu ccugaauuuu     1080

acacaaaacg uguucaccga cucuaucuuu gaaaaguguu ccacacuugu gaaacuggag     1140

acccucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggucggacu caugacgaaa     1200

gacaugccua gccuggagau ucuggaugug ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcacaugggu ugaaucuauc gugguccuga accuuagcuc caauaugcug     1320

accgacagcg uguuccggug ucuucccccg cgcauuaagg uucuggaucu gcauucuaac     1380

aaaaucaagu ccauuccuaa acaggugguc aaacuugagg cccuccagga acugaaugug     1440

gcguuuaaca gccugaccga ccuccccggc ugcgggucuu ucuccagccu guccguccuu     1500

aucauugauc acaauucugu gagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca ucaaggcugg agauaacccc uuucagugca caugcgagcu gcgggaguuc     1620

guuaagaaca ucgaccaggu guccagcgaa guccucgagg gcuggcccga cucuuacaaa     1680

ugugauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua uuacccuucu caucgugaca auuggagcca cgaugcuggu ucuggcugug     1800

accgucacaa gccucuguau cuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacccaga cacggcgcag agcccggaac auuccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuaucuc uuauagcgag caugacuccg ccugggugaa aagcgaacuu     1980

guucccuacc uggagaagga agauauccaa auuugucucc acgagcgcaa cuucgucccu     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauugaaa aguccuauaa gagcaucuuu     2100

gugcuguccc ccaauuucgu ccagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uucuccugga accgaucccu     2220

cagaauagca uucccaacaa auaucacaag cugaaagccc uuaugaugca gcggaccuac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ccgcgccgcc     2340

uuuaacauga aacugacgcu cgugaccgag aauaacgacg uuaagagcug a              2391


<210>  9753
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__D1CSA0

<400>  9753

Met Thr Lys Asp Lys Glu Pro Ile Val Lys Ser Phe His Phe Val Cys 
1               5                   10                  15      


Leu Met Ile Ile Ile Val Gly Thr Arg Ile Gln Phe Ser Asp Gly Asn 
            20                  25                  30          


Glu Phe Ala Val Asp Lys Ser Lys Arg Gly Leu Ile His Val Pro Lys 
        35                  40                  45              


Asp Leu Pro Leu Lys Thr Lys Val Leu Asp Met Ser Gln Asn Tyr Ile 
    50                  55                  60                  


Ala Glu Leu Gln Val Ser Asp Met Ser Phe Leu Ser Glu Leu Thr Val 
65                  70                  75                  80  


Leu Arg Leu Ser His Asn Arg Ile Gln Leu Leu Asp Leu Ser Val Phe 
                85                  90                  95      


Lys Phe Asn Gln Asp Leu Glu Tyr Leu Asp Leu Ser His Asn Gln Leu 
            100                 105                 110         


Gln Lys Ile Ser Cys His Pro Thr Val Ser Phe Arg His Leu Asp Leu 
        115                 120                 125             


Ser Phe Asn Asp Phe Lys Ala Leu Pro Ile Cys Lys Glu Phe Gly Asn 
    130                 135                 140                 


Leu Ser Gln Leu Asn Phe Leu Gly Leu Ser Ala Met Lys Leu Gln Lys 
145                 150                 155                 160 


Leu Asp Leu Leu Pro Ile Ala His Leu His Leu Ser Tyr Ile Leu Leu 
                165                 170                 175     


Asp Leu Arg Asn Tyr Tyr Ile Lys Glu Asn Glu Thr Glu Ser Leu Gln 
            180                 185                 190         


Ile Leu Asn Ala Lys Thr Leu His Leu Val Phe His Pro Thr Ser Leu 
        195                 200                 205             


Phe Ala Ile Gln Val Asn Ile Ser Val Asn Thr Leu Gly Cys Leu Gln 
    210                 215                 220                 


Leu Thr Asn Ile Lys Leu Asn Asp Asp Asn Cys Gln Val Phe Ile Lys 
225                 230                 235                 240 


Phe Leu Ser Glu Leu Thr Arg Gly Pro Thr Leu Leu Asn Phe Thr Leu 
                245                 250                 255     


Asn His Ile Glu Thr Thr Trp Lys Cys Leu Val Arg Val Phe Gln Phe 
            260                 265                 270         


Leu Trp Pro Lys Pro Val Glu Tyr Leu Asn Ile Tyr Asn Leu Thr Ile 
        275                 280                 285             


Ile Glu Ser Ile Arg Glu Glu Asp Phe Thr Tyr Ser Lys Thr Thr Leu 
    290                 295                 300                 


Lys Ala Leu Thr Ile Glu His Ile Thr Asn Gln Val Phe Leu Phe Ser 
305                 310                 315                 320 


Gln Thr Ala Leu Tyr Thr Val Phe Ser Glu Met Asn Ile Met Met Leu 
                325                 330                 335     


Thr Ile Ser Asp Thr Pro Phe Ile His Met Leu Cys Pro His Ala Pro 
            340                 345                 350         


Ser Thr Phe Lys Phe Leu Asn Phe Thr Gln Asn Val Phe Thr Asp Ser 
        355                 360                 365             


Ile Phe Glu Lys Cys Ser Thr Leu Val Lys Leu Glu Thr Leu Ile Leu 
    370                 375                 380                 


Gln Lys Asn Gly Leu Lys Asp Leu Phe Lys Val Gly Leu Met Thr Lys 
385                 390                 395                 400 


Asp Met Pro Ser Leu Glu Ile Leu Asp Val Ser Trp Asn Ser Leu Glu 
                405                 410                 415     


Ser Gly Arg His Lys Glu Asn Cys Thr Trp Val Glu Ser Ile Val Val 
            420                 425                 430         


Leu Asn Leu Ser Ser Asn Met Leu Thr Asp Ser Val Phe Arg Cys Leu 
        435                 440                 445             


Pro Pro Arg Ile Lys Val Leu Asp Leu His Ser Asn Lys Ile Lys Ser 
    450                 455                 460                 


Ile Pro Lys Gln Val Val Lys Leu Glu Ala Leu Gln Glu Leu Asn Val 
465                 470                 475                 480 


Ala Phe Asn Ser Leu Thr Asp Leu Pro Gly Cys Gly Ser Phe Ser Ser 
                485                 490                 495     


Leu Ser Val Leu Ile Ile Asp His Asn Ser Val Ser His Pro Ser Ala 
            500                 505                 510         


Asp Phe Phe Gln Ser Cys Gln Lys Met Arg Ser Ile Lys Ala Gly Asp 
        515                 520                 525             


Asn Pro Phe Gln Cys Thr Cys Glu Leu Arg Glu Phe Val Lys Asn Ile 
    530                 535                 540                 


Asp Gln Val Ser Ser Glu Val Leu Glu Gly Trp Pro Asp Ser Tyr Lys 
545                 550                 555                 560 


Cys Asp Tyr Pro Glu Ser Tyr Arg Gly Ser Pro Leu Lys Asp Phe His 
                565                 570                 575     


Met Ser Glu Leu Ser Cys Asn Ile Thr Leu Leu Ile Val Thr Ile Gly 
            580                 585                 590         


Ala Thr Met Leu Val Leu Ala Val Thr Val Thr Ser Leu Cys Ile Tyr 
        595                 600                 605             


Leu Asp Leu Pro Trp Tyr Leu Arg Met Val Cys Gln Trp Thr Gln Thr 
    610                 615                 620                 


Arg Arg Arg Ala Arg Asn Ile Pro Leu Glu Glu Leu Gln Arg Asn Leu 
625                 630                 635                 640 


Gln Phe His Ala Phe Ile Ser Tyr Ser Glu His Asp Ser Ala Trp Val 
                645                 650                 655     


Lys Ser Glu Leu Val Pro Tyr Leu Glu Lys Glu Asp Ile Gln Ile Cys 
            660                 665                 670         


Leu His Glu Arg Asn Phe Val Pro Gly Lys Ser Ile Val Glu Asn Ile 
        675                 680                 685             


Ile Asn Cys Ile Glu Lys Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro 
    690                 695                 700                 


Asn Phe Val Gln Ser Glu Trp Cys His Tyr Glu Leu Tyr Phe Ala His 
705                 710                 715                 720 


His Asn Leu Phe His Glu Gly Ser Asn Asn Leu Ile Leu Ile Leu Leu 
                725                 730                 735     


Glu Pro Ile Pro Gln Asn Ser Ile Pro Asn Lys Tyr His Lys Leu Lys 
            740                 745                 750         


Ala Leu Met Met Gln Arg Thr Tyr Leu Gln Trp Pro Lys Glu Lys Ser 
        755                 760                 765             


Lys Arg Gly Leu Phe Trp Ala Asn Ile Arg Ala Ala Phe Asn Met Lys 
    770                 775                 780                 


Leu Thr Leu Val Thr Glu Asn Asn Asp Val Lys Ser 
785                 790                 795     


<210>  9754
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR6__Homo_sapiens__AAY88762

<400>  9754
augaccaaag acaaagaacc uauuguuaaa agcuuccauu uuguuugccu uaugaucaua       60

auaguuggaa ccagaaucca guucuccgac ggaaaugaau uugcaguaga caagucaaaa      120

agaggucuua uucauguucc aaaagaccua ccgcugaaaa ccaaagucuu agauaugucu      180

cagaacuaca ucgcugagcu ucaggucucu gacaugagcu uucuaucaga guugacaguu      240

uugagacuuu cccauaacag aauccagcua cuugauuuaa guguuuucaa guucaaccag      300

gauuuagaau auuuggauuu aucucauaau caguugcaaa agauauccug ccauccuacu      360

gugaguuuca ggcauuuaga ucucucauuc aaugauuuca aggcccugcc caucuguaag      420

gaauuuggca acuuaucaca acugaauuuc uugggauuga gugcuaugaa gcugcaaaaa      480

uuagauuugc ugccaauugc ucacuugcau cuaaguuaua uccuucugga uuuaagaaau      540

uauuauauaa aagaaaauga gacagaaagu cuacaaauuc ugaaugcaaa aacccuucac      600

cuuguuuuuc acccaacuag uuuauucgcu auccaaguga acauaucagu uaauacuuua      660

gggugcuuac aacugacuaa uauuaaauug aaugaugaca acugucaagu uuucauuaaa      720

uuuuuaucag aacucaccag agguccaacc uuacugaauu uuacccucaa ccacauagaa      780

acgacuugga aaugccuggu cagagucuuu caauuucuuu ggcccaaacc uguggaauau      840

cucaauauuu acaauuuaac aauaauugaa agcauucgug aagaagauuu uacuuauucu      900

aaaacgacau ugaaagcauu gacaauagaa cauaucacga accaaguuuu ucuguuuuca      960

cagacagcuu uguacaccgu guuuucugag augaacauua ugauguuaac cauuucagau     1020

acaccuuuua uacacaugcu guguccucau gcaccaagca cauucaaguu uuugaacuuu     1080

acgcagaacg uuuucacaga uaguauuuuu gaaaaauguu ccacguuagu uaaauuggag     1140

acacuuaucu uacaaaagaa uggauuaaaa gaccuuuuca aaguaggucu caugacgaag     1200

gauaugccuu cuuuggaaau acuggauguu agcuggaauu cuuuggaauc ugguagacau     1260

aaggaaaacu gcacuugggu ugagaguaua gugguguuaa auuugucuuc aaauaugcuu     1320

acugacucug uuuucagaug uuuaccuccc aggaucaagg uacuugaucu ucacagcaau     1380

aaaauaaaga gcauuccuaa acaagucgua aaacuggaag cuuugcaaga acucaauguu     1440

gcuuucaauu cuuuaacuga ccuuccugga uguggcagcu uuagcagccu uucuguauug     1500

aucauugauc acaauucagu uucccaccca ucggcugauu ucuuccagag cugccagaag     1560

augaggucaa uaaaagcagg ggacaaucca uuccaaugua ccugugagcu aagagaauuu     1620

gucaaaaaua uagaccaagu aucaagugaa guguuagagg gcuggccuga uucuuauaag     1680

ugugacuacc cagaaaguua uagaggaagc ccacuaaagg acuuucacau gucugaauua     1740

uccugcaaca uaacucugcu gaucgucacc aucggugcca ccaugcuggu guuggcugug     1800

acugugaccu cccucugcau cuacuuggau cugcccuggu aucucaggau ggugugccag     1860

uggacccaga cucggcgcag ggccaggaac auacccuuag aagaacucca aagaaaccuc     1920

caguuucaug cuuuuauuuc auauagugaa caugauucug ccugggugaa aagugaauug     1980

guaccuuacc uagaaaaaga agauauacag auuugucuuc augagagaaa cuuugucccu     2040

ggcaagagca uuguggaaaa uaucaucaac ugcauugaga agaguuacaa guccaucuuu     2100

guuuugucuc ccaacuuugu ccagagugag uggugccauu acgaacucua uuuugcccau     2160

cacaaucucu uucaugaagg aucuaauaac uuaauccuca ucuuacugga acccauucca     2220

cagaacagca uucccaacaa guaccacaag cugaaggcuc ucaugaugca gcggacuuau     2280

uugcaguggc ccaaggagaa aagcaaacgu gggcucuuuu gggcuaacau uagagccgcu     2340

uuuaauauga aauuaacacu agucacugaa aacaaugaug ugaaaucuua a              2391


<210>  9755
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR6__Homo_sapiens__AAY88762

<400>  9755
augaccaagg acaaggagcc caucgucaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca cccgcaucca guucuccgac gggaacgagu ucgccgugga caagagcaag      120

cggggccuca uccacguccc gaaggaccug ccccugaaga cgaaggugcu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggugagc gacauguccu uccugagcga gcugaccguc      240

cugcgccugu cccacaaccg gauccagcuc cuggaccuga gcguguucaa guucaaccag      300

gaccucgagu accuggaccu gucccacaac cagcuccaga agaucagcug ccaccccacc      360

guguccuucc gccaccugga ccugagcuuc aacgacuuca aggcgcuccc caucugcaag      420

gaguucggga accuguccca gcugaacuuc cucggccuga gcgccaugaa gcugcagaag      480

cucgaccugc ugccgaucgc ccaccuccac cuguccuaca uccugcucga ccugcggaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ucaacgccaa gacgcugcac      600

cuggucuucc accccaccuc ccucuucgcc auccagguga acaucagcgu gaacacccug      660

gggugccugc agcucaccaa caucaagcug aacgacgaca acugccaggu cuucaucaag      720

uuccuguccg agcucacgcg cggccccacc cugcugaacu ucacccucaa ccacaucgag      780

accacgugga agugccuggu gcggguguuc caguuccugu ggcccaagcc ggucgaguac      840

cucaacaucu acaaccugac caucaucgag agcauccgcg aggaggacuu caccuacagc      900

aagaccacgc ugaaggcgcu gaccaucgag cacaucacca accagguguu ccucuucucc      960

cagaccgccc uguacacggu guucagcgag augaacauca ugaugcugac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acgcagaacg ucuucaccga cuccaucuuc gagaagugca gcacccuggu gaagcucgag     1140

acccugaucc ugcagaagaa cggccucaag gaccuguuca agguggggcu gaugacgaag     1200

gacaugccgu cccucgagau ccuggacguc agcuggaacu cccuggagag cggccggcac     1260

aaggagaacu gcaccugggu ggaguccauc gugguccuca accugagcuc caacaugcug     1320

accgacagcg uguuccgcug ccucccgccc cggaucaagg uccuggaccu gcacuccaac     1380

aagaucaaga gcauccccaa gcaggucgug aagcucgagg cccugcagga gcugaacgug     1440

gcguucaacu cccucaccga ccugcccggg ugcggcagcu ucuccagccu gagcgugcuc     1500

aucaucgacc acaacuccgu gagccacccc uccgccgacu ucuuccagag cugccagaag     1560

augcgcucca ucaaggccgg ggacaacccc uuccagugca cgugcgagcu gcgggaguuc     1620

gucaagaaca ucgaccaggu gagcuccgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc cggaguccua ccgcggcagc ccccucaagg acuuccacau guccgagcug     1740

agcugcaaca ucacccugcu caucgucacc aucggggcca ccaugcuggu gcuggccgug     1800

acggucaccu cccucugcau cuaccuggac cugcccuggu accuccggau ggugugccag     1860

uggacccaga cccgccggcg cgcgcggaac aucccccugg aggagcugca gcgcaaccuc     1920

caguuccacg ccuucaucag cuacuccgag cacgacagcg ccugggugaa guccgagcug     1980

gucccguacc uggagaagga ggacauccag aucugccucc acgagcggaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga aguccuacaa gagcaucuuc     2100

guccugagcc ccaacuucgu gcaguccgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccucu uccacgaggg gagcaacaac cugauccuga uccuccugga gcccaucccg     2220

cagaacucca uccccaacaa guaccacaag cugaaggccc ucaugaugca gcgcaccuac     2280

cugcaguggc ccaaggagaa guccaagcgc ggccuguucu gggcgaacau ccgggccgcc     2340

uucaacauga agcucacgcu ggugaccgag aacaacgacg ucaagagcug a              2391


<210>  9756
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR6__Homo_sapiens__AAY88762

<400>  9756
augaccaagg acaaggagcc caucgucaag uccuuccacu ucgucugccu caugaucauc       60

aucgucggca cccgcaucca guucuccgac ggcaacgagu ucgccgucga caaguccaag      120

cgcggccuca uccacguccc caaggaccuc ccccucaaga ccaagguccu cgacaugucc      180

cagaacuaca ucgccgagcu ccaggucucc gacauguccu uccucuccga gcucaccguc      240

cuccgccucu cccacaaccg cauccagcuc cucgaccucu ccgucuucaa guucaaccag      300

gaccucgagu accucgaccu cucccacaac cagcuccaga agaucuccug ccaccccacc      360

gucuccuucc gccaccucga ccucuccuuc aacgacuuca aggcccuccc caucugcaag      420

gaguucggca accucuccca gcucaacuuc cucggccucu ccgccaugaa gcuccagaag      480

cucgaccucc uccccaucgc ccaccuccac cucuccuaca uccuccucga ccuccgcaac      540

uacuacauca aggagaacga gaccgagucc cuccagaucc ucaacgccaa gacccuccac      600

cucgucuucc accccaccuc ccucuucgcc auccagguca acaucuccgu caacacccuc      660

ggcugccucc agcucaccaa caucaagcuc aacgacgaca acugccaggu cuucaucaag      720

uuccucuccg agcucacccg cggccccacc cuccucaacu ucacccucaa ccacaucgag      780

accaccugga agugccucgu ccgcgucuuc caguuccucu ggcccaagcc cgucgaguac      840

cucaacaucu acaaccucac caucaucgag uccauccgcg aggaggacuu caccuacucc      900

aagaccaccc ucaaggcccu caccaucgag cacaucacca accaggucuu ccucuucucc      960

cagaccgccc ucuacaccgu cuucuccgag augaacauca ugaugcucac caucuccgac     1020

acccccuuca uccacaugcu cugcccccac gcccccucca ccuucaaguu ccucaacuuc     1080

acccagaacg ucuucaccga cuccaucuuc gagaagugcu ccacccucgu caagcucgag     1140

acccucaucc uccagaagaa cggccucaag gaccucuuca aggucggccu caugaccaag     1200

gacaugcccu cccucgagau ccucgacguc uccuggaacu cccucgaguc cggccgccac     1260

aaggagaacu gcaccugggu cgaguccauc gucguccuca accucuccuc caacaugcuc     1320

accgacuccg ucuuccgcug ccuccccccc cgcaucaagg uccucgaccu ccacuccaac     1380

aagaucaagu ccauccccaa gcaggucguc aagcucgagg cccuccagga gcucaacguc     1440

gccuucaacu cccucaccga ccuccccggc ugcggcuccu ucuccucccu cuccguccuc     1500

aucaucgacc acaacuccgu cucccacccc uccgccgacu ucuuccaguc cugccagaag     1560

augcgcucca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu ccgcgaguuc     1620

gucaagaaca ucgaccaggu cuccuccgag guccucgagg gcuggcccga cuccuacaag     1680

ugcgacuacc ccgaguccua ccgcggcucc ccccucaagg acuuccacau guccgagcuc     1740

uccugcaaca ucacccuccu caucgucacc aucggcgcca ccaugcucgu ccucgccguc     1800

accgucaccu cccucugcau cuaccucgac cuccccuggu accuccgcau ggucugccag     1860

uggacccaga cccgccgccg cgcccgcaac aucccccucg aggagcucca gcgcaaccuc     1920

caguuccacg ccuucaucuc cuacuccgag cacgacuccg ccugggucaa guccgagcuc     1980

guccccuacc ucgagaagga ggacauccag aucugccucc acgagcgcaa cuucgucccc     2040

ggcaagucca ucgucgagaa caucaucaac ugcaucgaga aguccuacaa guccaucuuc     2100

guccucuccc ccaacuucgu ccaguccgag uggugccacu acgagcucua cuucgcccac     2160

cacaaccucu uccacgaggg cuccaacaac cucauccuca uccuccucga gcccaucccc     2220

cagaacucca uccccaacaa guaccacaag cucaaggccc ucaugaugca gcgcaccuac     2280

cuccaguggc ccaaggagaa guccaagcgc ggccucuucu gggccaacau ccgcgccgcc     2340

uucaacauga agcucacccu cgucaccgag aacaacgacg ucaaguccug a              2391


<210>  9757
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR6__Homo_sapiens__AAY88762

<400>  9757
augaccaagg acaaagagcc caucgugaag uccuuccacu uugucugccu gaugauuaua       60

aucguuggca caaggauuca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

agaggacuca uccauguacc uaaagaucuu ccacugaaga cuaagguguu ggacauguca      180

caaaauuaca uugcugaguu acaggucagu gauaugagcu uccuguccga acuaacggug      240

cuccggcugu cucacaaccg cauccagcuu cuggacuugu cgguuuuuaa auucaaucag      300

gaucucgagu aucuggaccu gucacauaac caacuccaga agauaagcug ucacccgacc      360

gugaguuuuc gacauuuaga ucuguccuuc aaugacuuua aagcacuucc caucugcaag      420

gaguucggua acuugucuca gcugaauuuu cuaggccuca gcgccaugaa acugcagaaa      480

cuugaucugu ugccuauugc gcaccuccac cuguccuaca ucuuacugga ccuccguaac      540

uauuacauua aggagaauga gacagaauca cuucaaaucc ugaacgcuaa gacuuugcau      600

cuagucuucc acccaaccag ucuguuugcc auacagguga auauuagcgu aaacacacuc      660

gggugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu uuucauuaaa      720

uucuugucug agcucacuag aggacccaca cuguuaaacu uuacccugaa ccauaucgaa      780

acgacuugga agugucuagu gagggucuuc caauuucucu ggccuaaacc aguggaguau      840

cugaauaucu acaaccuuac cauuauagag uccauccggg aagaggacuu cacauauuca      900

aagacuaccu ugaaagcacu gacaauugaa cacaucacca aucagguguu ucucuucagc      960

cagacggccc uguacacugu cuuuagugag augaacauaa ugaugcuuac aauuucugau     1020

acccccuuca uccacaugcu gugcccucau gcuccaucca cuuuuaaguu cuugaauuuu     1080

acacaaaacg uuuucaccga cagcaucuuu gaaaaguguu cgacgcucgu gaaacuggag     1140

accuuaauuc ugcagaagaa uggccuaaaa gaucucuuca agguaggucu gaugacaaaa     1200

gacaugccgu cucuugagau cuuggaugug uccuggaacu cacuggaaag ugggcgccac     1260

aaggagaauu gcacuugggu cgaaagcauu gugguucuca accuguccuc uaauauguua     1320

accgacagcg uguucagaug ucugcccccu aggauaaagg uccuugauuu gcauucaaac     1380

aaaaucaaga guauuccaaa acagguggua aagcucgagg cacugcagga acuaaauguu     1440

gccuuuaacu cccugacaga ccuccccgga ugcggcagcu ucucuucacu gagugugcuu     1500

aucaucgauc acaauagcgu cucccauccu ucugcugacu uuuuccaauc gugucagaaa     1560

augcggagca uuaaggccgg cgauaaccca uuucagugca cuugcgaguu gcgcgaguuc     1620

gugaagaaca uagaccaggu cuccucagaa gugcuggagg gguggcccga caguuacaaa     1680

ugugauuauc cggaaucuua ccgaggaagc ccuuuaaagg acuuucacau guccgagcuc     1740

ucaugcaaua ucacccugcu uauuguuaca aucggugcga ccaugcuggu guuggcagua     1800

acugucacga gccucuguau uuaucuggau cuacccuggu accugagaau ggugugccaa     1860

uggacacaga ccaggcggcg ugcccgcaac aucccacucg aagaacugca gagaaaucuu     1920

caguuccacg cuuuuauauc uuauuccgag caugacagug ccuggguuaa aagcgaauug     1980

gugccuuacc uggagaagga agauauccaa auuuguuuac acgagaggaa cuucgucccc     2040

ggcaaaucua ucguggagaa uauuaucaac ugcauagaaa aguccuauaa gucaauuuuu     2100

guacucaguc caaauuucgu gcagagcgag uggugucauu acgaacugua cuuugcacac     2160

cacaaccuuu uccaugaggg gucgaauaac cugauccuaa uucuccugga acccaucccu     2220

cagaauagca uaccaaacaa auaucacaag uugaaagcuc ugaugaugca gcggacuuac     2280

uuacaauggc cgaaggagaa aucuaagcga ggacucuucu gggccaauau ccgcgcggcc     2340

uuuaacauga aacugacccu uguuacagag aauaacgacg ucaagagcug a              2391


<210>  9758
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR6__Homo_sapiens__AAY88762

<400>  9758
augaccaagg acaaggagcc caucgugaag agcuuccacu ucgugugccu gaugaucauc       60

aucgugggca ccagaaucca guucagcgac ggcaacgagu ucgccgugga caagagcaag      120

agaggccuga uccacgugcc caaggaccug ccccugaaga ccaaggugcu ggacaugagc      180

cagaacuaca ucgccgagcu gcaggugagc gacaugagcu uccugagcga gcugaccgug      240

cugagacuga gccacaacag aauccagcug cuggaccuga gcguguucaa guucaaccag      300

gaccuggagu accuggaccu gagccacaac cagcugcaga agaucagcug ccaccccacc      360

gugagcuuca gacaccugga ccugagcuuc aacgacuuca aggcccugcc caucugcaag      420

gaguucggca accugagcca gcugaacuuc cugggccuga gcgccaugaa gcugcagaag      480

cuggaccugc ugcccaucgc ccaccugcac cugagcuaca uccugcugga ccugagaaac      540

uacuacauca aggagaacga gaccgagagc cugcagaucc ugaacgccaa gacccugcac      600

cugguguucc accccaccag ccuguucgcc auccagguga acaucagcgu gaacacccug      660

ggcugccugc agcugaccaa caucaagcug aacgacgaca acugccaggu guucaucaag      720

uuccugagcg agcugaccag aggccccacc cugcugaacu ucacccugaa ccacaucgag      780

accaccugga agugccuggu gagaguguuc caguuccugu ggcccaagcc cguggaguac      840

cugaacaucu acaaccugac caucaucgag agcaucagag aggaggacuu caccuacagc      900

aagaccaccc ugaaggcccu gaccaucgag cacaucacca accagguguu ccuguucagc      960

cagaccgccc uguacaccgu guucagcgag augaacauca ugaugcugac caucagcgac     1020

acccccuuca uccacaugcu gugcccccac gcccccagca ccuucaaguu ccugaacuuc     1080

acccagaacg uguucaccga cagcaucuuc gagaagugca gcacccuggu gaagcuggag     1140

acccugaucc ugcagaagaa cggccugaag gaccuguuca aggugggccu gaugaccaag     1200

gacaugccca gccuggagau ccuggacgug agcuggaaca gccuggagag cggcagacac     1260

aaggagaacu gcaccugggu ggagagcauc guggugcuga accugagcag caacaugcug     1320

accgacagcg uguucagaug ccugcccccc agaaucaagg ugcuggaccu gcacagcaac     1380

aagaucaaga gcauccccaa gcagguggug aagcuggagg cccugcagga gcugaacgug     1440

gccuucaaca gccugaccga ccugcccggc ugcggcagcu ucagcagccu gagcgugcug     1500

aucaucgacc acaacagcgu gagccacccc agcgccgacu ucuuccagag cugccagaag     1560

augagaagca ucaaggccgg cgacaacccc uuccagugca ccugcgagcu gagagaguuc     1620

gugaagaaca ucgaccaggu gagcagcgag gugcuggagg gcuggcccga cagcuacaag     1680

ugcgacuacc ccgagagcua cagaggcagc ccccugaagg acuuccacau gagcgagcug     1740

agcugcaaca ucacccugcu gaucgugacc aucggcgcca ccaugcuggu gcuggccgug     1800

accgugacca gccugugcau cuaccuggac cugcccuggu accugagaau ggugugccag     1860

uggacccaga ccagaagaag agccagaaac aucccccugg aggagcugca gagaaaccug     1920

caguuccacg ccuucaucag cuacagcgag cacgacagcg ccugggugaa gagcgagcug     1980

gugcccuacc uggagaagga ggacauccag aucugccugc acgagagaaa cuucgugccc     2040

ggcaagagca ucguggagaa caucaucaac ugcaucgaga agagcuacaa gagcaucuuc     2100

gugcugagcc ccaacuucgu gcagagcgag uggugccacu acgagcugua cuucgcccac     2160

cacaaccugu uccacgaggg cagcaacaac cugauccuga uccugcugga gcccaucccc     2220

cagaacagca uccccaacaa guaccacaag cugaaggccc ugaugaugca gagaaccuac     2280

cugcaguggc ccaaggagaa gagcaagaga ggccuguucu gggccaacau cagagccgcc     2340

uucaacauga agcugacccu ggugaccgag aacaacgacg ugaagagcug a              2391


<210>  9759
<211>  2391
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR6__Homo_sapiens__AAY88762

<400>  9759
augaccaagg acaaagagcc caucgugaag uccuuccacu uugugugccu gaugauuauc       60

auuguuggca caagaaucca guucuccgau gggaacgaau uugccgugga caaaucuaag      120

cggggacuca uucaugugcc uaaagaucug ccgcuuaaga cgaagguccu ggacaugagc      180

caaaauuaca ucgcugagcu ccaggugucc gauaugucuu uccugagcga acuuaccguu      240

cugcgccucu cccacaacag aauccagcug cuggaccucu cuguguuuaa auucaaucag      300

gaucuggagu aucuugaccu gagccauaac caacuccaga agauuuccug ucaccccaca      360

gucagcuuuc ggcaucugga ucuuucuuuc aaugacuuua aagcccugcc uaucugcaag      420

gaguucggca accucuccca gcugaauuuu cuggggcuca gcgcgaugaa acugcagaag      480

cucgaucugc uccccauugc ucaucugcac cuuucuuaca uccugcucga ccugcgcaac      540

uauuacauua aggagaauga gaccgaaucc cugcaaaucc ucaacgccaa aacacugcac      600

cuuguguucc acccuaccag ccuguuugcc auucagguua auaucucugu gaacacacuc      660

ggaugucugc agcuuaccaa uaucaagcug aacgaugaca auugccaggu cuucauuaaa      720

uuccucuccg agcugacgag aggccccacc cugcucaacu uuacacugaa ccauaucgaa      780

accacaugga agugucuugu gcggguguuc caauuucugu ggccuaaacc ggucgaguau      840

cucaauauuu acaaccugac caucauugag agcauccgcg aagaggacuu cacguauucc      900

aagacaaccc ugaaagcucu uacaaucgaa cacauuacca aucagguuuu ucucuucucu      960

cagaccgccc uguacacagu guuuagcgag augaacauca ugaugcugac gauuuccgau     1020

acccccuuca uccacaugcu cugcccucau gcucccagca cauuuaaguu ccugaauuuu     1080

acccaaaacg uguucacaga cucuauuuuu gaaaaguguu ccacccuugu caaacuggag     1140

acgcucaucc ugcagaagaa ugggcugaaa gaucuuuuca aggugggacu caugacaaaa     1200

gacaugccua gccuggagau ccuggauguu ucuuggaaca gccucgaauc cggcagacac     1260

aaggagaauu gcaccugggu ggaaucuauu gucgugcuga accuuagcuc caauaugcug     1320

accgacagcg uuuuccggug ucuucccccg cgcaucaagg ugcuggaucu gcauucuaac     1380

aaaauuaagu ccaucccuaa acaggucgug aaacuugagg cccuccagga acugaauguc     1440

gcguuuaaca gccugacaga ccuccccggc ugcgggucuu ucuccagccu guccgugcuu     1500

auuaucgauc acaauucugu uagccauccu uccgccgacu uuuuccaauc uugucagaag     1560

augagaagca uuaaggcugg agauaacccc uuucagugua ccugcgagcu gcgggaguuc     1620

gugaagaaca ucgaccaggu cuccagcgaa gugcucgagg gcuggcccga cucuuacaaa     1680

ugcgauuauc cugaauccua ccgcgggagc ccgcugaagg acuuucacau gucugagcug     1740

uccugcaaua ucacacuucu cauuguuacg aucggagcca ccaugcuggu gcuggcuguc     1800

acagugacca gccucuguau uuaucuggau cuucccuggu accugagaau ggugugccaa     1860

uggacacaga cccggcgcag agcccggaac aucccucucg aagaacugca gagaaaucug     1920

caguuccacg cguuuauuuc uuauagcgag caugacuccg ccuggguuaa aagcgaacuu     1980

guccccuacc uggagaagga agauauccaa aucugucucc acgagcgcaa cuucgugccu     2040

ggcaaaucua uuguggagaa uaucauuaac ugcaucgaaa aguccuauaa gagcauuuuu     2100

guccuguccc ccaauuucgu gcagucugag uggugucauu acgaacucua cuuugcucac     2160

cacaaccugu uccaugaggg gagcaauaac cuuauccuga uccuccugga accgauuccu     2220

cagaauagca uccccaacaa auaucacaag cugaaagccc uuaugaugca gcggacguac     2280

cugcaauggc cuaaggagaa aucuaagaga ggacucuucu gggcuaauau ucgcgccgcc     2340

uuuaacauga aacugacccu cguuacagag aauaacgacg ucaagagcug a              2391


<210>  9760
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__B2R9N9

<400>  9760

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys 
        995                 1000                1005            


Gly Ser Ser Val Leu Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr 
    1010                1015                1020                


Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala 
1025                1030                1035                1040


Tyr Ser Gln Val Phe Lys Glu Thr Val 
                1045                


<210>  9761
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__AAZ99022

<400>  9761
augguguuuc caauguggac acugaagaga caaauucuua uccuuuuuaa cauaauccua       60

auuuccaaac uccuuggggc uagaugguuu ccuaaaacuc ugcccuguga ugucacucug      120

gauguuccaa agaaccaugu gaucguggac ugcacagaca agcauuugac agaaauuccu      180

ggagguauuc ccacgaacac cacgaaccuc acccucacca uuaaccacau accagacauc      240

uccccagcgu ccuuucacag acuggaccau cugguagaga ucgauuucag augcaacugu      300

guaccuauuc cacugggguc aaaaaacaac augugcauca agaggcugca gauuaaaccc      360

agaagcuuua guggacucac uuauuuaaaa ucccuuuacc uggauggaaa ccagcuacua      420

gagauaccgc agggccuccc gccuagcuua cagcuucuca gccuugaggc caacaacauc      480

uuuuccauca gaaaagagaa ucuaacagaa cuggccaaca uagaaauacu cuaccugggc      540

caaaacuguu auuaucgaaa uccuuguuau guuucauauu caauagagaa agaugccuuc      600

cuaaacuuga caaaguuaaa agugcucucc cugaaagaua acaaugucac agccgucccu      660

acuguuuugc caucuacuuu aacagaacua uaucucuaca acaacaugau ugcaaaaauc      720

caagaagaug auuuuaauaa ccucaaccaa uuacaaauuc uugaccuaag uggaaauugc      780

ccucguuguu auaaugcccc auuuccuugu gcgccgugua aaaauaauuc uccccuacag      840

aucccuguaa augcuuuuga ugcgcugaca gaauuaaaag uuuuacgucu acacaguaac      900

ucucuucagc augugccccc aagaugguuu aagaacauca acaaacucca ggaacuggau      960

cugucccaaa acuucuuggc caaagaaauu ggggaugcua aauuucugca uuuucucccc     1020

agccucaucc aauuggaucu gucuuucaau uuugaacuuc aggucuaucg ugcaucuaug     1080

aaucuaucac aagcauuuuc uucacugaaa agccugaaaa uucugcggau cagaggauau     1140

gucuuuaaag aguugaaaag cuuuaaccuc ucgccauuac auaaucuuca aaaucuugaa     1200

guucuugauc uuggcacuaa cuuuauaaaa auugcuaacc ucagcauguu uaaacaauuu     1260

aaaagacuga aagucauaga ucuuucagug aauaaaauau caccuucagg agauucaagu     1320

gaaguuggcu ucugcucaaa ugccagaacu ucuguagaaa guuaugaacc ccagguccug     1380

gaacaauuac auuauuucag auaugauaag uaugcaagga guugcagauu caaaaacaaa     1440

gaggcuucuu ucaugucugu uaaugaaagc ugcuacaagu augggcagac cuuggaucua     1500

aguaaaaaua guauauuuuu ugucaagucc ucugauuuuc agcaucuuuc uuuccucaaa     1560

ugccugaauc ugucaggaaa ucucauuagc caaacucuua auggcaguga auuccaaccu     1620

uuagcagagc ugagauauuu ggacuucucc aacaaccggc uugauuuacu ccauucaaca     1680

gcauuugaag agcuucacaa acuggaaguu cuggauauaa gcaguaauag ccauuauuuu     1740

caaucagaag gaauuacuca uaugcuaaac uuuaccaaga accuaaaggu ucugcagaaa     1800

cugaugauga acgacaauga caucucuucc uccaccagca ggaccaugga gagugagucu     1860

cuuagaacuc uggaauucag aggaaaucac uuagauguuu uauggagaga aggugauaac     1920

agauacuuac aauuauucaa gaaucugcua aaauuagagg aauuagacau cucuaaaaau     1980

ucccuaaguu ucuugccuuc uggaguuuuu gaugguaugc cuccaaaucu aaagaaucuc     2040

ucuuuggcca aaaaugggcu caaaucuuuc aguuggaaga aacuccagug ucuaaagaac     2100

cuggaaacuu uggaccucag ccacaaccaa cugaccacug ucccugagag auuauccaac     2160

uguuccagaa gccucaagaa ucugauucuu aagaauaauc aaaucaggag ucugacgaag     2220

uauuuucuac aagaugccuu ccaguugcga uaucuggauc ucagcucaaa uaaaauccag     2280

augauccaaa agaccagcuu cccagaaaau guccucaaca aucugaagau guugcuuuug     2340

caucauaauc gguuucugug caccugugau gcuguguggu uugucuggug gguuaaccau     2400

acggagguga cuauuccuua ccuggccaca gaugugacuu guguggggcc aggagcacac     2460

aagggccaaa gugugaucuc ccuggaucug uacaccugug aguuagaucu gacuaaccug     2520

auucuguucu cacuuuccau aucuguaucu cucuuucuca uggugaugau gacagcaagu     2580

caccucuauu ucugggaugu gugguauauu uaccauuucu guaaggccaa gauaaagggg     2640

uaucagcguc uaauaucacc agacuguugc uaugaugcuu uuauugugua ugacacuaaa     2700

gacccagcug ugaccgagug gguuuuggcu gagcuggugg ccaaacugga agacccaaga     2760

gagaaacauu uuaauuuaug ucucgaggaa agggacuggu uaccagggca gccaguucug     2820

gaaaaccuuu cccagagcau acagcuuagc aaaaagacag uguuugugau gacagacaag     2880

uaugcaaaga cugaaaauuu uaagauagca uuuuacuugu cccaucagag gcucauggau     2940

gaaaaaguug augugauuau cuugauauuu cuugagaagc ccuuucagaa guccaaguuc     3000

cuccagcucc ggaaaaggcu cugugggagu ucuguccuug aguggccaac aaacccgcaa     3060

gcucacccau acuucuggca gugucugaag aacgcccugg ccacagacaa ucauguggcc     3120

uauagucagg uguucaagga aacggucuag                                      3150


<210>  9762
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR7__Homo_sapiens__AAZ99022

<400>  9762
augguguucc ccauguggac ccugaagcgc cagauccuca uccuguucaa caucauccug       60

aucagcaagc uccugggcgc ccggugguuc ccgaagaccc ugcccugcga cgucacgcuc      120

gacgugccca agaaccacgu gaucgucgac ugcaccgaca agcaccugac cgagaucccc      180

gggggcaucc cgaccaacac gaccaaccug acccucacca ucaaccacau ccccgacauc      240

ucccccgcca gcuuccaccg ccuggaccac cugguggaga ucgacuuccg gugcaacugc      300

gugcccaucc cgcucggguc caagaacaac augugcauca agcgccugca gaucaagccc      360

cggagcuucu ccggccugac guaccucaag agccuguacc uggacgggaa ccagcuccug      420

gagauccccc agggccugcc cccgucccuc cagcugcuga gccucgaggc gaacaacauc      480

uucuccaucc gcaaggagaa ccugaccgag cuggccaaca ucgagauccu cuaccugggc      540

cagaacugcu acuaccggaa ccccugcuac gucagcuacu ccaucgagaa ggacgccuuc      600

cugaaccuca ccaagcugaa ggugcugagc cucaaggaca acaacgugac cgccgucccc      660

acggugcugc ccuccacccu gaccgagcuc uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccugaaccag cuccagaucc uggaccugag cgggaacugc      780

ccgcgcugcu acaacgcgcc cuuccccugc gcccccugca agaacaacuc cccgcuccag      840

auccccguga acgccuucga cgcccugacc gagcugaagg uccuccggcu gcacagcaac      900

ucccugcagc acgugccgcc ccgcugguuc aagaacauca acaagcucca ggagcuggac      960

cugagccaga acuuccuggc gaaggagauc ggcgacgcca aguuccucca cuuccugccc     1020

ucccugaucc agcucgaccu gagcuucaac uucgagcucc agguguaccg ggccagcaug     1080

aaccucuccc aggccuucag cucccucaag agccugaaga uccugcgcau ccggggguac     1140

gucuucaagg agcugaaguc cuucaaccug agcccccucc acaaccugca gaaccuggag     1200

gugcucgacc ugggcacgaa cuucaucaag aucgccaacc uguccauguu caagcaguuc     1260

aagcgccuca aggugaucga ccugagcguc aacaagaucu cccccagcgg ggacuccagc     1320

gaggugggcu ucugcuccaa cgcgcggacc agcguggagu ccuacgagcc ccagguccug     1380

gagcagcucc acuacuuccg cuacgacaag uacgcccgga gcugccgcuu caagaacaag     1440

gaggccuccu ucaugagcgu gaacgagucc ugcuacaagu acggccagac ccuggaccug     1500

agcaagaaca gcaucuucuu cgugaagucc agcgacuucc agcaccucuc cuuccugaag     1560

ugccugaacc ucagcgggaa ccugaucucc cagacccuga acggcagcga guuccagccg     1620

cucgccgagc ugcgguaccu ggacuucucc aacaaccgcc ucgaccugcu gcacagcacg     1680

gccuucgagg agcuccacaa gcuggagguc cuggacaucu ccagcaacuc ccacuacuuc     1740

cagagcgagg ggaucaccca caugcucaac uucaccaaga accugaaggu gcugcagaag     1800

cucaugauga acgacaacga caucuccagc uccaccagcc ggacgaugga guccgagagc     1860

cugcgcaccc uggaguuccg cggcaaccac cucgacgucc uguggcggga gggcgacaac     1920

cgcuaccugc agcuguucaa gaaccugcug aagcucgagg agcuggacau cagcaagaac     1980

ucccugagcu uccuccccuc cgggguguuc gacggcaugc ccccgaaccu gaagaaccug     2040

agccucgcga agaacgggcu gaaguccuuc agcuggaaga agcugcagug ccucaagaac     2100

cuggagaccc uggaccucuc ccacaaccag cugaccacgg ugcccgagcg gcugagcaac     2160

ugcucccgca gccucaagaa ccugauccug aagaacaacc agauccgguc ccucaccaag     2220

uacuuccugc aggacgccuu ccagcugcgc uaccucgacc ugagcuccaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac guccugaaca accucaagau gcugcugcuc     2340

caccacaacc gguuccugug cacgugcgac gccguguggu ucguguggug ggucaaccac     2400

accgagguga ccauccccua ccuggccacc gacgugaccu gcgucggccc gggggcccac     2460

aagggccagu ccgugaucag ccucgaccug uacacgugcg agcuggaccu caccaaccug     2520

auccuguucu cccucagcau cuccgugagc cuguuccuga uggucaugau gaccgcgagc     2580

caccucuacu ucugggacgu gugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagcgcc ugaucucccc cgacugcugc uacgacgccu ucaucgugua cgacaccaag     2700

gaccccgccg ucaccgagug ggugcuggcc gagcucgugg cgaagcugga ggacccccgg     2760

gagaagcacu ucaaccugug ccuggaggag cgcgacuggc ucccggggca gcccguccug     2820

gagaaccuga gccaguccau ccagcucagc aagaagacgg uguucgugau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccugu cccaccagcg gcugauggac     2940

gagaaggucg acgugaucau ccucaucuuc cuggagaagc ccuuccagaa guccaaguuc     3000

cugcagcucc gcaagcggcu gugcggcagc agcgugcugg aguggcccac caacccgcag     3060

gcccaccccu acuucuggca gugccucaag aacgcgcugg ccacggacaa ccacgucgcc     3120

uacucccagg uguucaagga gaccguguga                                      3150


<210>  9763
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR7__Homo_sapiens__AAZ99022

<400>  9763
auggucuucc ccauguggac ccucaagcgc cagauccuca uccucuucaa caucauccuc       60

aucuccaagc uccucggcgc ccgcugguuc cccaagaccc uccccugcga cgucacccuc      120

gacgucccca agaaccacgu caucgucgac ugcaccgaca agcaccucac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccuc acccucacca ucaaccacau ccccgacauc      240

ucccccgccu ccuuccaccg ccucgaccac cucgucgaga ucgacuuccg cugcaacugc      300

guccccaucc cccucggcuc caagaacaac augugcauca agcgccucca gaucaagccc      360

cgcuccuucu ccggccucac cuaccucaag ucccucuacc ucgacggcaa ccagcuccuc      420

gagauccccc agggccuccc ccccucccuc cagcuccucu cccucgaggc caacaacauc      480

uucuccaucc gcaaggagaa ccucaccgag cucgccaaca ucgagauccu cuaccucggc      540

cagaacugcu acuaccgcaa ccccugcuac gucuccuacu ccaucgagaa ggacgccuuc      600

cucaaccuca ccaagcucaa gguccucucc cucaaggaca acaacgucac cgccgucccc      660

accguccucc ccuccacccu caccgagcuc uaccucuaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccucaaccag cuccagaucc ucgaccucuc cggcaacugc      780

ccccgcugcu acaacgcccc cuuccccugc gcccccugca agaacaacuc cccccuccag      840

auccccguca acgccuucga cgcccucacc gagcucaagg uccuccgccu ccacuccaac      900

ucccuccagc acgucccccc ccgcugguuc aagaacauca acaagcucca ggagcucgac      960

cucucccaga acuuccucgc caaggagauc ggcgacgcca aguuccucca cuuccucccc     1020

ucccucaucc agcucgaccu cuccuucaac uucgagcucc aggucuaccg cgccuccaug     1080

aaccucuccc aggccuucuc cucccucaag ucccucaaga uccuccgcau ccgcggcuac     1140

gucuucaagg agcucaaguc cuucaaccuc uccccccucc acaaccucca gaaccucgag     1200

guccucgacc ucggcaccaa cuucaucaag aucgccaacc ucuccauguu caagcaguuc     1260

aagcgccuca aggucaucga ccucuccguc aacaagaucu cccccuccgg cgacuccucc     1320

gaggucggcu ucugcuccaa cgcccgcacc uccgucgagu ccuacgagcc ccagguccuc     1380

gagcagcucc acuacuuccg cuacgacaag uacgcccgcu ccugccgcuu caagaacaag     1440

gaggccuccu ucauguccgu caacgagucc ugcuacaagu acggccagac ccucgaccuc     1500

uccaagaacu ccaucuucuu cgucaagucc uccgacuucc agcaccucuc cuuccucaag     1560

ugccucaacc ucuccggcaa ccucaucucc cagacccuca acggcuccga guuccagccc     1620

cucgccgagc uccgcuaccu cgacuucucc aacaaccgcc ucgaccuccu ccacuccacc     1680

gccuucgagg agcuccacaa gcucgagguc cucgacaucu ccuccaacuc ccacuacuuc     1740

caguccgagg gcaucaccca caugcucaac uucaccaaga accucaaggu ccuccagaag     1800

cucaugauga acgacaacga caucuccucc uccaccuccc gcaccaugga guccgagucc     1860

cuccgcaccc ucgaguuccg cggcaaccac cucgacgucc ucuggcgcga gggcgacaac     1920

cgcuaccucc agcucuucaa gaaccuccuc aagcucgagg agcucgacau cuccaagaac     1980

ucccucuccu uccuccccuc cggcgucuuc gacggcaugc cccccaaccu caagaaccuc     2040

ucccucgcca agaacggccu caaguccuuc uccuggaaga agcuccagug ccucaagaac     2100

cucgagaccc ucgaccucuc ccacaaccag cucaccaccg uccccgagcg ccucuccaac     2160

ugcucccgcu cccucaagaa ccucauccuc aagaacaacc agauccgcuc ccucaccaag     2220

uacuuccucc aggacgccuu ccagcuccgc uaccucgacc ucuccuccaa caagauccag     2280

augauccaga agaccuccuu ccccgagaac guccucaaca accucaagau gcuccuccuc     2340

caccacaacc gcuuccucug caccugcgac gccgucuggu ucgucuggug ggucaaccac     2400

accgagguca ccauccccua ccucgccacc gacgucaccu gcgucggccc cggcgcccac     2460

aagggccagu ccgucaucuc ccucgaccuc uacaccugcg agcucgaccu caccaaccuc     2520

auccucuucu cccucuccau cuccgucucc cucuuccuca uggucaugau gaccgccucc     2580

caccucuacu ucugggacgu cugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagcgcc ucaucucccc cgacugcugc uacgacgccu ucaucgucua cgacaccaag     2700

gaccccgccg ucaccgagug gguccucgcc gagcucgucg ccaagcucga ggacccccgc     2760

gagaagcacu ucaaccucug ccucgaggag cgcgacuggc uccccggcca gcccguccuc     2820

gagaaccucu cccaguccau ccagcucucc aagaagaccg ucuucgucau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccucu cccaccagcg ccucauggac     2940

gagaaggucg acgucaucau ccucaucuuc cucgagaagc ccuuccagaa guccaaguuc     3000

cuccagcucc gcaagcgccu cugcggcucc uccguccucg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccucaag aacgcccucg ccaccgacaa ccacgucgcc     3120

uacucccagg ucuucaagga gaccgucuga                                      3150


<210>  9764
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR7__Homo_sapiens__AAZ99022

<400>  9764
augguguucc ccauguggac ccugaagaga cagauccuca uucuuuuuaa cauaauccug       60

auuagcaaau uguuaggcgc caggugguuc ccuaagacac ugccaugcga cgucacucua      120

gauguuccga aaaaucacgu gaucguagac uguacggaua agcaucucac cgagauuccc      180

gggggaaucc cuacaaacac uaccaaucug acacuuacca uaaaccacau cccagacauu      240

ucccccgcuu cuuuucaucg gcuggaucac uugguggaaa ucgacuuccg cugcaauugu      300

gucccuauuc cacucgguag caaaaacaau augugcauca agcgacugca aauaaagccc      360

cguaguuuua gcggccugac uuaccucaaa uccuuauauc uggaugggaa ccagcuuuug      420

gagauuccuc agggacugcc accgucucua cagcuccugu cgcuugaagc aaauaacauc      480

uucucaauua gaaaggagaa ucugacagaa uuggccaaca ucgagauccu cuaccugggc      540

caaaauuguu auuacaggaa ccccugcuau gugagcuaca guauugagaa agacgcguuu      600

uuaaaucuga ccaagcucaa aguucuuucc cugaaggaua acaacgugac ggcugucccu      660

acuguguugc caucuacccu aacagaacug uaucucuaca auaacaugau agccaagauc      720

caggaggacg auuucaauaa ccugaaucag cuucagauuc uggacuugag cgguaacugu      780

ccccggugcu acaaugcacc uuuuccaugu gcccccugca aaaacaauuc cccgcuccaa      840

aucccuguaa acgcuuucga ugcacugacu gaauuaaagg uucugcgccu acauucaaau      900

agucuccagc acgugccccc aagaugguuu aaaaacauaa auaagcugca ggagcuugac      960

uugagccaga acuuccuggc caaagagauu ggggacgcua aguuucucca cuuccugccu     1020

ucucuuaucc aacuggauuu guccuucaau uuugaacucc aggucuauag ggccucaaug     1080

aaccugagcc aggcguucag uucuuuaaaa ucccugaaga uccuacggau ucgcggauac     1140

guguuuaagg agcucaaauc auucaaccug ucgccccuuc auaauuugca aaaccuggaa     1200

gugcucgacc ugggcaccaa uuuuaucaag auugcaaacu uaucuauguu caaacaguuu     1260

aagcgacuga aagucauaga ucuuuccguu aauaagaucu caccaagugg cgacagcucc     1320

gagguggggu ucuguucuaa cgccagaaca agcguagaau cauaugagcc ccagguguug     1380

gagcagcucc acuacuuuag guaugauaag uacgcucgga guugccguuu caaaaauaag     1440

gaagccuccu uuaugagcgu caacgagucu ugcuauaaau acggacaaac ccuggaccua     1500

ucaaagaaua guauuuucuu ugugaaaagc uccgauuucc agcaucuguc uuuccucaag     1560

ugucugaacc uuucggguaa uuugaucagc cagacgcuga acggcuccga auuucagccu     1620

uuagcagagc uccgcuaccu ggacuucuca aauaacagac uugaucuguu gcacaguacu     1680

gcuuuugaag aacuccacaa gcuggagguu cuagacaucu cuagcaauuc ccauuauuuc     1740

caaucagaag ggauuacaca caugcugaac uuuaccaaaa accucaaggu gcugcagaaa     1800

cuuaugauga augauaacga cauaaguucu uccacuagca ggacaaugga gagcgaaucu     1860

uugcggaccc uggaguuccg aggaaaucau uuagacgucc ucuggcgcga aggcgauaac     1920

agauaccugc agcuuuuuaa gaaucugcua aaacucgagg agcuggacau cuccaagaac     1980

ucauugaguu uccugccaag cgguguguuu gaugggaugc cgcccaauuu aaagaaccuc     2040

ucgcuggcca aaaauggacu uaaguccuuc ucuuggaaaa agcugcagug cuugaaaaac     2100

cucgaaacgc uggaccuaag ccacaaucaa cugaccacag uaccugagag gcuuucaaac     2160

uguagucggu cccucaagaa ucugauuuug aaaaacaauc agauccgcuc ucugacuaag     2220

uacuuuuuac aggaugcguu ccagcucaga uaucuggacc uuagcuccaa caagauucaa     2280

augauccaga aaaccucauu uccagaaaac guucugaaua acuugaagau gcuccugcua     2340

caucacaaua gguuccugug cacaugugau gccguguggu ucgucuggug ggugaaccac     2400

acugagguca ccauacccua ucuugcaaca gacgugaccu gcguuggccc uggcgcucau     2460

aaagggcaga gcgugaucag ucucgaucug uacacuugug aguuggacuu aacgaaucug     2520

auucucuuuu cucuguccau cagcguaucg cuuuuccuga uggucaugau gacagccuca     2580

cacuuguauu uuugggaugu gugguacauu uaccauuucu gcaaggcuaa aaucaaggga     2640

uaucaacguc uaauaucucc agacuguugc uacgaugccu uuauuguuua ugacaccaag     2700

gaccccgcag ugacugaaug gguccuggcc gagcucgugg cuaaacugga agauccgcgg     2760

gagaagcacu ucaaccuuug uuuagaggag cgagacuggc ugccugguca gccaguacuc     2820

gagaauuuga gucaguccau ccagcugagc aaaaagaccg uguuuguuau gacagauaaa     2880

uacgcgaaga ccgaaaacuu caagauugca uuuuaucucu cucaccaaag acugauggac     2940

gagaaagucg augugaucau acuuaucuuc cuggaaaagc ccuuucagaa aagcaaguuc     3000

uugcagcuaa ggaaacgccu gugcggcucc ucagugcucg aguggccuac uaauccccag     3060

gcccauccau acuucuggca augcuuaaag aacgcucugg ccacagacaa ucacgucgca     3120

uauagucagg uuuuuaagga aacgguguga                                      3150


<210>  9765
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR7__Homo_sapiens__AAZ99022

<400>  9765
augguguucc ccauguggac ccugaagaga cagauccuga uccuguucaa caucauccug       60

aucagcaagc ugcugggcgc cagaugguuc cccaagaccc ugcccugcga cgugacccug      120

gacgugccca agaaccacgu gaucguggac ugcaccgaca agcaccugac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccug acccugacca ucaaccacau ccccgacauc      240

agccccgcca gcuuccacag acuggaccac cugguggaga ucgacuucag augcaacugc      300

gugcccaucc cccugggcag caagaacaac augugcauca agagacugca gaucaagccc      360

agaagcuuca gcggccugac cuaccugaag agccuguacc uggacggcaa ccagcugcug      420

gagauccccc agggccugcc ccccagccug cagcugcuga gccuggaggc caacaacauc      480

uucagcauca gaaaggagaa ccugaccgag cuggccaaca ucgagauccu guaccugggc      540

cagaacugcu acuacagaaa ccccugcuac gugagcuaca gcaucgagaa ggacgccuuc      600

cugaaccuga ccaagcugaa ggugcugagc cugaaggaca acaacgugac cgccgugccc      660

accgugcugc ccagcacccu gaccgagcug uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccugaaccag cugcagaucc uggaccugag cggcaacugc      780

cccagaugcu acaacgcccc cuuccccugc gcccccugca agaacaacag cccccugcag      840

auccccguga acgccuucga cgcccugacc gagcugaagg ugcugagacu gcacagcaac      900

agccugcagc acgugccccc cagaugguuc aagaacauca acaagcugca ggagcuggac      960

cugagccaga acuuccuggc caaggagauc ggcgacgcca aguuccugca cuuccugccc     1020

agccugaucc agcuggaccu gagcuucaac uucgagcugc agguguacag agccagcaug     1080

aaccugagcc aggccuucag cagccugaag agccugaaga uccugagaau cagaggcuac     1140

guguucaagg agcugaagag cuucaaccug agcccccugc acaaccugca gaaccuggag     1200

gugcuggacc ugggcaccaa cuucaucaag aucgccaacc ugagcauguu caagcaguuc     1260

aagagacuga aggugaucga ccugagcgug aacaagauca gccccagcgg cgacagcagc     1320

gaggugggcu ucugcagcaa cgccagaacc agcguggaga gcuacgagcc ccaggugcug     1380

gagcagcugc acuacuucag auacgacaag uacgccagaa gcugcagauu caagaacaag     1440

gaggccagcu ucaugagcgu gaacgagagc ugcuacaagu acggccagac ccuggaccug     1500

agcaagaaca gcaucuucuu cgugaagagc agcgacuucc agcaccugag cuuccugaag     1560

ugccugaacc ugagcggcaa ccugaucagc cagacccuga acggcagcga guuccagccc     1620

cuggccgagc ugagauaccu ggacuucagc aacaacagac uggaccugcu gcacagcacc     1680

gccuucgagg agcugcacaa gcuggaggug cuggacauca gcagcaacag ccacuacuuc     1740

cagagcgagg gcaucaccca caugcugaac uucaccaaga accugaaggu gcugcagaag     1800

cugaugauga acgacaacga caucagcagc agcaccagca gaaccaugga gagcgagagc     1860

cugagaaccc uggaguucag aggcaaccac cuggacgugc uguggagaga gggcgacaac     1920

agauaccugc agcuguucaa gaaccugcug aagcuggagg agcuggacau cagcaagaac     1980

agccugagcu uccugcccag cggcguguuc gacggcaugc cccccaaccu gaagaaccug     2040

agccuggcca agaacggccu gaagagcuuc agcuggaaga agcugcagug ccugaagaac     2100

cuggagaccc uggaccugag ccacaaccag cugaccaccg ugcccgagag acugagcaac     2160

ugcagcagaa gccugaagaa ccugauccug aagaacaacc agaucagaag ccugaccaag     2220

uacuuccugc aggacgccuu ccagcugaga uaccuggacc ugagcagcaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac gugcugaaca accugaagau gcugcugcug     2340

caccacaaca gauuccugug caccugcgac gccguguggu ucguguggug ggugaaccac     2400

accgagguga ccauccccua ccuggccacc gacgugaccu gcgugggccc cggcgcccac     2460

aagggccaga gcgugaucag ccuggaccug uacaccugcg agcuggaccu gaccaaccug     2520

auccuguuca gccugagcau cagcgugagc cuguuccuga uggugaugau gaccgccagc     2580

caccuguacu ucugggacgu gugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagagac ugaucagccc cgacugcugc uacgacgccu ucaucgugua cgacaccaag     2700

gaccccgccg ugaccgagug ggugcuggcc gagcuggugg ccaagcugga ggaccccaga     2760

gagaagcacu ucaaccugug ccuggaggag agagacuggc ugcccggcca gcccgugcug     2820

gagaaccuga gccagagcau ccagcugagc aagaagaccg uguucgugau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccuga gccaccagag acugauggac     2940

gagaaggugg acgugaucau ccugaucuuc cuggagaagc ccuuccagaa gagcaaguuc     3000

cugcagcuga gaaagagacu gugcggcagc agcgugcugg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccugaag aacgcccugg ccaccgacaa ccacguggcc     3120

uacagccagg uguucaagga gaccguguga                                      3150


<210>  9766
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR7__Homo_sapiens__AAZ99022

<400>  9766
augguguucc ccauguggac ccugaagaga cagauccuca uucuguuuaa caucauucuu       60

aucagcaaac ugcucggcgc ccggugguuc ccuaagacac ugccgugcga cgucacgcuu      120

gauguuccca aaaaucacgu gauuguggac uguaccgaua agcaucugac agagaucccu      180

gggggaaucc ccaccaacac aaccaaucuc acacugacca uuaaccacau cccugacauu      240

ucccccgcuu cuuuucaucg ccuggaucac cucgucgaaa ucgacuucag augcaauugu      300

gugccuauuc cgcugggcag caaaaacaau augugcauca agcggcuuca aauuaagccc      360

cgcuccuuuu cugggcugac guaccucaaa agccuguauc uugauggaaa ccagcugcuc      420

gagaucccuc agggccugcc cccuucccug cagcuccugu cucuugaagc caauaacauc      480

uucagcauua gaaaggagaa ucugaccgaa cucgcgaaca ucgagauucu guaccuuggg      540

caaaauuguu auuaccggaa ccccugcuau guuuccuaca gcaucgagaa agacgcuuuu      600

cugaaucuca caaagcugaa agugcugucu cucaaggaua acaacgucac cgccgugccg      660

acaguucugc cuuccacccu uacggaacug uaucucuaca auaacaugau ugccaagauc      720

caggaggacg auuucaauaa ccugaaucag cuucagaucc uggaccucag cggaaacugu      780

ccccgcugcu acaaugcucc uuuucccugu gcccccugca aaaacaauuc uccucugcaa      840

auuccgguga acgcuuucga ugcccugaca gaacucaagg uccugagacu ucauuccaau      900

agccugcagc acgugccccc ucggugguuu aaaaacauca auaagcucca ggagcuggac      960

cugucucaga acuuccuugc gaaagagauu ggcgacgcca aguuucucca cuuccugccc     1020

ucccugaucc aacucgaucu gagcuucaau uuugaacuuc agguguaucg cgcuuccaug     1080

aaccugucuc aggccuucag cucccucaaa agccugaaga uucugagaau ccggggcuac     1140

gucuuuaagg agcuuaaauc uuucaaccuc uccccucugc auaaucugca aaaccucgaa     1200

guucuggacc uugggaccaa uuuuaucaag auugcuaacc ugagcauguu caaacaguuu     1260

aagcgccuca aagugaucga ucugucugug aauaagauua gccccuccgg agacucuagc     1320

gaggucggcu ucuguuccaa cgccagaaca agcguggaau cuuaugagcc gcagguucug     1380

gagcagcuuc acuacuuucg guaugauaag uacgcgcgcu ccugcagauu caaaaauaag     1440

gaagccagcu uuaugucugu gaacgagucc ugcuauaaau acgggcaaac ccucgaccug     1500

agcaaaaauu ccaucuucuu ugucaagucu agcgauuucc agcaucuguc cuuccucaag     1560

ugucugaacc uuucuggaaa ucugauuagc cagacccuca acggcuccga auuucagccu     1620

cuggcugagc ugcgguaccu ugacuucagc aauaacagac ucgaucugcu gcacucuaca     1680

gccuuugaag aacuccacaa gcuggaggug cuugacaucu ccagcaauuc ucauuauuuc     1740

caauccgaag ggauuacgca caugcugaac uuuaccaaaa accucaaggu ucugcagaaa     1800

cugaugauga augauaacga caucagcucu agcacauccc gcaccaugga gagcgaaucu     1860

cuucggacac uggaguucag aggaaaucau cucgacgugc uguggcgcga aggcgauaac     1920

cgguaccucc agcuguuuaa gaaucuucug aaacucgagg agcuggacau cuccaagaac     1980

agccuguccu uccuucccuc uggcgucuuu gaugggaugc cucccaaucu gaagaaccuc     2040

agccuggcua aaaauggacu caaguccuuc ucuuggaaaa agcugcagug ccuuaaaaac     2100

cuggaaaccc ucgaccugag ccacaaucaa cugacgacag ugccugagag acuuuccaac     2160

uguucucgca gccugaagaa ucucauucug aaaaacaauc agauccgguc ccucaccaag     2220

uauuuucugc aggaugccuu ccagcuuaga uaccuggacc ugagcucuaa caagauucaa     2280

augauccaga aaaccuccuu ucccgaaaac guccucaaua accugaagau gcuucugcuc     2340

caucacaauc gcuuccugug cacaugugau gccguguggu ucguuuggug ggugaaccac     2400

accgagguca caauuccgua ucucgcuacg gacgugaccu gcguuggccc uggggcgcau     2460

aaaggacaga gcgugaucuc ucuggaucuu uacacaugug agcuggaccu gaccaaucuc     2520

auccuguuuu cccuuagcau uucugucucc cuguuccuca uggugaugau gacagccagc     2580

caccuguauu uuugggaugu gugguacauc uaccauuucu gcaaggcuaa aauuaagggc     2640

uaucaacggc ucaucucccc cgacuguugc uacgaugccu uuauuguuua ugacaccaag     2700

gaccccgccg ucacggaaug ggugcuggcu gagcuugugg ccaaacugga agauccuaga     2760

gagaagcacu ucaaccugug ucucgaggag cgcgacuggc ugccggggca gcccguccuu     2820

gagaaucuga gccagucuau ccagcucagc aaaaagaccg uguuuguuau gacagauaaa     2880

uacgcgaaga ccgaaaacuu caagaucgcu uuuuaucugu cccaccaacg gcucauggac     2940

gagaaagugg augucauuau ccugauuuuc cuugaaaagc cuuuucagaa aucuaaguuc     3000

cugcagcuga gaaaacggcu cugcggaagc uccgugcugg aguggcccac aaauccucag     3060

gcccaucccu acuucuggca augccuuaag aacgcccugg cuaccgacaa ucacguugcc     3120

uauucucagg uguuuaagga aacggucuga                                      3150


<210>  9767
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__D1CS68

<400>  9767

Met Val Phe Pro Met Trp Thr Leu Lys Arg Leu Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Val 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys 
        995                 1000                1005            


Gly Ser Ser Val Leu Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr 
    1010                1015                1020                


Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala 
1025                1030                1035                1040


Tyr Ser Gln Val Phe Lys Glu Thr Val 
                1045                


<210>  9768
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__AAZ99025

<400>  9768
augguguuuc caauguggac acugaagaga cuaauucuua uccuuuuuaa cauaauccua       60

auuuccaaac uccuuggggc uagaugguuu ccuaaaacuc ugcccuguga ugucacucug      120

gauguuccaa agaaccaugu gaucguggac ugcacagaca agcauuugac agaaauuccu      180

ggagguauuc ccacgaacac cacgaaccuc acccucacca uuaaccacau accagacauc      240

uccccagcgu ccuuucacag acuggaccau cugguagaga ucgauuucag augcaacugu      300

guaccuauuc cacugggguc aaaaaacaac augugcauca agaggcugca gauuaaaccc      360

agaagcuuua guggacucac uuauuuaaaa ucccuuuacc uggauggaaa ccagcuacua      420

gagauaccgc agggccuccc gccuagcuua cagcuucuca gccuugaggc caacaacauc      480

uuuuccauca gaaaagagaa ucuaacagaa cuggccaaca uagaaauacu cuaccugggc      540

caaaacuguu auuaucgaaa uccuuguuau guuucauauu caauagagaa agaugccuuc      600

cuaaacuuga caaaguuaaa agugcucucc cugaaagaua acaaugucac agccgucccu      660

acuguuuugc caucuacuuu aacagaacua uaucucuaca acaacaugau ugcaaaaauc      720

caagaagaug auuuuaauaa ccucaaccaa uuacaaauuc uugaccuaag uggaaauugc      780

ccucguuguu auaaugcccc auuuccuugu gcgccgugua aaaauaauuc uccccuacag      840

aucccuguaa augcuuuuga ugcgcugaca gaauuaaaag uuuuacgucu acacaguaac      900

ucucuucagc augugccccc aagaugguuu aagaacauca acaaacucca ggaacuggau      960

cugucccaaa acuucuuggc caaagaaauu ggggaugcua aauuucugca uuuucucccc     1020

agccucaucc aauuggaucu gucuuucaau uuugaacuuc aggucuaucg ugcaucuaug     1080

aaucuaucac aagcauuuuc uucacugaaa agccugaaaa uucugcggau cagaggauau     1140

gucuuuaaag aguugaaaag cuuuaaccuc ucgccauuac auaaucuuca aaaucuugaa     1200

guucuugauc uuggcacuaa cuuuauaaaa auugcuaacc ucagcauguu uaaacaauuu     1260

aaaagacuga aagucauaga ucuuucagug aauaaaauau caccuucagg agauucaagu     1320

gaaguuggcu ucugcucaaa ugucagaacu ucuguagaaa guuaugaacc ccagguccug     1380

gaacaauuac auuauuucag auaugauaag uaugcaagga guugcagauu caaaaacaaa     1440

gaggcuucuu ucaugucugu uaaugaaagc ugcuacaagu augggcagac cuuggaucua     1500

aguaaaaaua guauauuuuu ugucaagucc ucugauuuuc agcaucuuuc uuuccucaaa     1560

ugccugaauc ugucaggaaa ucucauuagc caaacucuua auggcaguga auuccaaccu     1620

uuagcagagc ugagauauuu ggacuucucc aacaaccggc uugauuuacu ccauucaaca     1680

gcauuugaag agcuucacaa acuggaaguu cuggauauaa gcaguaauag ccauuauuuu     1740

caaucagaag gaauuacuca uaugcuaaac uuuaccaaga accuaaaggu ucugcagaaa     1800

cugaugauga acgacaauga caucucuucc uccaccagca ggaccaugga gagugagucu     1860

cuuagaacuc uggaauucag aggaaaucac uuagauguuu uauggagaga aggugauaac     1920

agauacuuac aauuauucaa gaaucugcua aaauuagagg aauuagacau cucuaaaaau     1980

ucccuaaguu ucuugccuuc uggaguuuuu gaugguaugc cuccaaaucu aaagaaucuc     2040

ucuuuggcca aaaaugggcu caaaucuuuc aguuggaaga aacuccagug ucuaaagaac     2100

cuggaaacuu uggaccucag ccacaaccaa cugaccacug ucccugagag auuauccaac     2160

uguuccagaa gccucaagaa ucugauucuu aagaauaauc aaaucaggag ucugacgaag     2220

uauuuucuac aagaugccuu ccaguugcga uaucuggauc ucagcucaaa uaaaauccag     2280

augauccaaa agaccagcuu cccagaaaau guccucaaca aucugaagau guugcuuuug     2340

caucauaauc gguuucugug caccugugau gcuguguggu uugucuggug gguuaaccau     2400

acggagguga cuauuccuua ccuggccaca gaugugacuu guguggggcc aggagcacac     2460

aagggccaaa gugugaucuc ccuggaucug uacaccugug aguuagaucu gacuaaccug     2520

auucuguucu cacuuuccau aucuguaucu cucuuucuca uggugaugau gacagcaagu     2580

caccucuauu ucugggaugu gugguauauu uaccauuucu guaaggccaa gauaaagggg     2640

uaucagcguc uaauaucacc agacuguugc uaugaugcuu uuauugugua ugacacuaaa     2700

gacccagcug ugaccgagug gguuuuggcu gagcuggugg ccaaacugga agacccaaga     2760

gagaaacauu uuaauuuaug ucucgaggaa agggacuggu uaccagggca gccaguucug     2820

gaaaaccuuu cccagagcau acagcuuagc aaaaagacag uguuugugau gacagacaag     2880

uaugcaaaga cugaaaauuu uaagauagca uuuuacuugu cccaucagag gcucauggau     2940

gaaaaaguug augugauuau cuugauauuu cuugagaagc ccuuucagaa guccaaguuc     3000

cuccagcucc ggaaaaggcu cugugggagu ucuguccuug aguggccaac aaacccgcaa     3060

gcucacccau acuucuggca gugucuaaag aacgcccugg ccacagacaa ucauguggcc     3120

uauagucagg uguucaagga aacggucuag                                      3150


<210>  9769
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR7__Homo_sapiens__AAZ99025

<400>  9769
augguguucc ccauguggac ccugaagcgc cucauccuga uccuguucaa caucauccuc       60

aucagcaagc ugcugggcgc ccggugguuc ccgaagaccc uccccugcga cgucacgcug      120

gacgugccca agaaccacgu gaucgucgac ugcaccgaca agcaccugac cgagaucccc      180

gggggcaucc cgaccaacac gaccaaccuc acccugacca ucaaccacau ccccgacauc      240

ucccccgcca gcuuccaccg ccuggaccac cucguggaga ucgacuuccg gugcaacugc      300

gugcccaucc cgcugggguc caagaacaac augugcauca agcgccugca gaucaagccc      360

cggagcuucu ccggccucac guaccucaag agccuguacc ucgacgggaa ccagcugcug      420

gagauccccc agggccugcc cccgucccug cagcugcuca gccuggaggc gaacaacauc      480

uucuccaucc gcaaggagaa ccugaccgag cucgccaaca ucgagauccu guaccugggc      540

cagaacugcu acuaccggaa ccccugcuac gucagcuacu ccaucgagaa ggacgccuuc      600

cucaaccuga ccaagcugaa ggugcucagc cugaaggaca acaacgugac cgccgucccc      660

acggugcugc ccuccacccu caccgagcug uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccucaaccag cugcagaucc uggaccucag cgggaacugc      780

ccgcgcugcu acaacgcgcc cuuccccugc gcccccugca agaacaacuc cccgcugcag      840

auccccguga acgccuucga cgcccugacc gagcucaagg uccugcggcu gcacagcaac      900

ucccuccagc acgugccgcc ccgcugguuc aagaacauca acaagcugca ggagcuggac      960

cugagccaga acuuccucgc gaaggagauc ggcgacgcca aguuccugca cuuccugccc     1020

ucccucaucc agcuggaccu gagcuucaac uucgagcucc agguguaccg ggccagcaug     1080

aaccuguccc aggccuucag cucccucaag agccugaaga uccugcgcau ccggggguac     1140

gucuucaagg agcugaaguc cuucaaccuc agcccccugc acaaccugca gaaccucgag     1200

gugcuggacc ugggcacgaa cuucaucaag aucgccaacc ucuccauguu caagcaguuc     1260

aagcgccuga aggugaucga ccugagcguc aacaagaucu cccccagcgg ggacuccagc     1320

gaggugggcu ucugcuccaa cgugcggacc agcgucgagu ccuacgagcc ccaggugcuc     1380

gagcagcugc acuacuuccg cuacgacaag uacgcgcgga gcugccgcuu caagaacaag     1440

gaggccuccu ucaugagcgu gaacgagucc ugcuacaagu acggccagac ccuggaccuc     1500

agcaagaaca gcaucuucuu cgucaagucc agcgacuucc agcaccuguc cuuccugaag     1560

ugccucaacc ugagcgggaa ccugaucucc cagacccuca acggcagcga guuccagccg     1620

cuggccgagc ugcgguaccu cgacuucucc aacaaccgcc uggaccugcu ccacagcacg     1680

gccuucgagg agcugcacaa gcuggaggug cucgacaucu ccagcaacuc ccacuacuuc     1740

cagagcgagg ggaucaccca caugcugaac uucaccaaga accugaaggu ccuccagaag     1800

cugaugauga acgacaacga caucuccagc uccaccagcc ggacgaugga guccgagagc     1860

cugcgcaccc ucgaguuccg cggcaaccac cuggacgugc uguggcggga gggcgacaac     1920

cgcuaccucc agcuguucaa gaaccugcuc aagcuggagg agcuggacau cagcaagaac     1980

ucccucagcu uccugcccuc cgggguguuc gacggcaugc ccccgaaccu gaagaaccuc     2040

agccuggcca agaacgggcu gaaguccuuc agcuggaaga agcuccagug ccugaagaac     2100

cuggagaccc ucgaccuguc ccacaaccag cugaccacgg uccccgagcg gcucagcaac     2160

ugcucccgca gccugaagaa ccugauccuc aagaacaacc agauccgguc ccugaccaag     2220

uacuuccugc aggacgcguu ccagcuccgc uaccuggacc ugagcuccaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac gugcucaaca accugaagau gcugcuccug     2340

caccacaacc gguuccugug cacgugcgac gccguguggu ucgucuggug ggugaaccac     2400

accgagguga ccauccccua ccucgccacc gacgugaccu gcgucggccc gggggcccac     2460

aagggccagu ccgugaucag ccuggaccug uacacgugcg agcucgaccu gaccaaccug     2520

auccucuucu cccugagcau cuccgucagc cuguuccuca uggugaugau gaccgccagc     2580

caccuguacu ucugggacgu gugguacauc uaccacuucu gcaaggcgaa gaucaagggc     2640

uaccagcgcc ugaucucccc cgacugcugc uacgacgccu ucaucgucua cgacaccaag     2700

gaccccgccg ugaccgagug ggugcucgcc gagcuggucg ccaagcugga ggacccccgg     2760

gagaagcacu ucaaccugug ccucgaggag cgcgacuggc ugccggggca gcccgugcug     2820

gagaaccuca gccaguccau ccagcugagc aagaagacgg uguucgucau gaccgacaag     2880

uacgcgaaga ccgagaacuu caagaucgcc uucuaccugu cccaccagcg gcucauggac     2940

gagaaggugg acgugaucau ccugaucuuc cuggagaagc ccuuccagaa guccaaguuc     3000

cuccagcugc gcaagcggcu gugcggcagc agcguccucg aguggcccac caacccgcag     3060

gcccaccccu acuucuggca gugccugaag aacgcccugg cgacggacaa ccacguggcc     3120

uacucccagg uguucaagga gaccgucuga                                      3150


<210>  9770
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR7__Homo_sapiens__AAZ99025

<400>  9770
auggucuucc ccauguggac ccucaagcgc cucauccuca uccucuucaa caucauccuc       60

aucuccaagc uccucggcgc ccgcugguuc cccaagaccc uccccugcga cgucacccuc      120

gacgucccca agaaccacgu caucgucgac ugcaccgaca agcaccucac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccuc acccucacca ucaaccacau ccccgacauc      240

ucccccgccu ccuuccaccg ccucgaccac cucgucgaga ucgacuuccg cugcaacugc      300

guccccaucc cccucggcuc caagaacaac augugcauca agcgccucca gaucaagccc      360

cgcuccuucu ccggccucac cuaccucaag ucccucuacc ucgacggcaa ccagcuccuc      420

gagauccccc agggccuccc ccccucccuc cagcuccucu cccucgaggc caacaacauc      480

uucuccaucc gcaaggagaa ccucaccgag cucgccaaca ucgagauccu cuaccucggc      540

cagaacugcu acuaccgcaa ccccugcuac gucuccuacu ccaucgagaa ggacgccuuc      600

cucaaccuca ccaagcucaa gguccucucc cucaaggaca acaacgucac cgccgucccc      660

accguccucc ccuccacccu caccgagcuc uaccucuaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccucaaccag cuccagaucc ucgaccucuc cggcaacugc      780

ccccgcugcu acaacgcccc cuuccccugc gcccccugca agaacaacuc cccccuccag      840

auccccguca acgccuucga cgcccucacc gagcucaagg uccuccgccu ccacuccaac      900

ucccuccagc acgucccccc ccgcugguuc aagaacauca acaagcucca ggagcucgac      960

cucucccaga acuuccucgc caaggagauc ggcgacgcca aguuccucca cuuccucccc     1020

ucccucaucc agcucgaccu cuccuucaac uucgagcucc aggucuaccg cgccuccaug     1080

aaccucuccc aggccuucuc cucccucaag ucccucaaga uccuccgcau ccgcggcuac     1140

gucuucaagg agcucaaguc cuucaaccuc uccccccucc acaaccucca gaaccucgag     1200

guccucgacc ucggcaccaa cuucaucaag aucgccaacc ucuccauguu caagcaguuc     1260

aagcgccuca aggucaucga ccucuccguc aacaagaucu cccccuccgg cgacuccucc     1320

gaggucggcu ucugcuccaa cguccgcacc uccgucgagu ccuacgagcc ccagguccuc     1380

gagcagcucc acuacuuccg cuacgacaag uacgcccgcu ccugccgcuu caagaacaag     1440

gaggccuccu ucauguccgu caacgagucc ugcuacaagu acggccagac ccucgaccuc     1500

uccaagaacu ccaucuucuu cgucaagucc uccgacuucc agcaccucuc cuuccucaag     1560

ugccucaacc ucuccggcaa ccucaucucc cagacccuca acggcuccga guuccagccc     1620

cucgccgagc uccgcuaccu cgacuucucc aacaaccgcc ucgaccuccu ccacuccacc     1680

gccuucgagg agcuccacaa gcucgagguc cucgacaucu ccuccaacuc ccacuacuuc     1740

caguccgagg gcaucaccca caugcucaac uucaccaaga accucaaggu ccuccagaag     1800

cucaugauga acgacaacga caucuccucc uccaccuccc gcaccaugga guccgagucc     1860

cuccgcaccc ucgaguuccg cggcaaccac cucgacgucc ucuggcgcga gggcgacaac     1920

cgcuaccucc agcucuucaa gaaccuccuc aagcucgagg agcucgacau cuccaagaac     1980

ucccucuccu uccuccccuc cggcgucuuc gacggcaugc cccccaaccu caagaaccuc     2040

ucccucgcca agaacggccu caaguccuuc uccuggaaga agcuccagug ccucaagaac     2100

cucgagaccc ucgaccucuc ccacaaccag cucaccaccg uccccgagcg ccucuccaac     2160

ugcucccgcu cccucaagaa ccucauccuc aagaacaacc agauccgcuc ccucaccaag     2220

uacuuccucc aggacgccuu ccagcuccgc uaccucgacc ucuccuccaa caagauccag     2280

augauccaga agaccuccuu ccccgagaac guccucaaca accucaagau gcuccuccuc     2340

caccacaacc gcuuccucug caccugcgac gccgucuggu ucgucuggug ggucaaccac     2400

accgagguca ccauccccua ccucgccacc gacgucaccu gcgucggccc cggcgcccac     2460

aagggccagu ccgucaucuc ccucgaccuc uacaccugcg agcucgaccu caccaaccuc     2520

auccucuucu cccucuccau cuccgucucc cucuuccuca uggucaugau gaccgccucc     2580

caccucuacu ucugggacgu cugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagcgcc ucaucucccc cgacugcugc uacgacgccu ucaucgucua cgacaccaag     2700

gaccccgccg ucaccgagug gguccucgcc gagcucgucg ccaagcucga ggacccccgc     2760

gagaagcacu ucaaccucug ccucgaggag cgcgacuggc uccccggcca gcccguccuc     2820

gagaaccucu cccaguccau ccagcucucc aagaagaccg ucuucgucau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccucu cccaccagcg ccucauggac     2940

gagaaggucg acgucaucau ccucaucuuc cucgagaagc ccuuccagaa guccaaguuc     3000

cuccagcucc gcaagcgccu cugcggcucc uccguccucg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccucaag aacgcccucg ccaccgacaa ccacgucgcc     3120

uacucccagg ucuucaagga gaccgucuga                                      3150


<210>  9771
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR7__Homo_sapiens__AAZ99025

<400>  9771
augguguucc ccauguggac ccugaagaga cucauccuua uucuguuuaa cauaaucuug       60

auuagcaaau uacugggcgc caggugguuc ccuaagacac uaccaugcga cgucacucuc      120

gauguuccga aaaaucacgu gaucguagac uguacggaua agcaucugac cgagauuccc      180

gggggaaucc cuacaaacac uaccaaucuu acacugacca uaaaccacau cccagacauu      240

ucccccgcuu cuuuucaucg guuggaucac cucguggaaa ucgacuuccg cugcaauugu      300

gucccuauuc cacuggguag caaaaacaau augugcauca agcgacugca gauaaagccc      360

cguaguuuua gcggccucac uuacuuaaaa ucccuguauc uugaugggaa ccaauugcug      420

gagauuccuc agggacuacc accgucucuc cagcugcuuu cgcuggaagc aaauaacauc      480

uucucaauua gaaaggagaa uuugacagaa cucgccaaca ucgagauccu guacuuaggc      540

cagaauuguu auuacaggaa ccccugcuau gugagcuaca guauugagaa agacgcguuu      600

cugaaucuca ccaaacuuaa aguucugucc uugaaggaua acaacgugac ggcugucccu      660

acugugcuac caucuacccu gacagaacuc uaucuguaca auaacaugau agccaagauc      720

caagaggacg auuucaauaa ccuuaaucag cugcagauuu uggaccucag cgguaacugu      780

ccccggugcu acaaugcacc uuuuccaugu gcccccugca aaaacaauuc cccgcugcag      840

aucccuguaa acgcuuucga ugcauuaacu gaacugaagg uucuacgccu ccauucaaau      900

agucugcaac acgugccccc aagaugguuu aaaaacauaa auaaacuuca ggaguuggac      960

cugagccaga acuuccucgc caaagagauu ggggacgcua aguuucugca cuuccuuccu     1020

ucucugaucc aguuggaucu cuccuucaau uuugaacugc aagucuauag ggccucaaug     1080

aacuuaagcc aggcguucag uucucugaaa ucccuaaaga uccuccggau ucgcggauac     1140

guguuuaagg agcugaaauc auucaaccuu ucgcccuugc auaaucugca gaaccucgaa     1200

gugcuggacu uaggcaccaa uuuuaucaag auugcaaacc ugucuauguu caaacaauuu     1260

aagcgacuua aagucauaga uuuguccguu aauaagaucu caccaagugg cgacagcucc     1320

gagguggggu ucuguucuaa cguaagaaca agcguggaau cauaugagcc ccagguccuc     1380

gagcagcugc acuacuuuag guaugauaag uacgcccgga guugccguuu caaaaauaag     1440

gaggcuuccu uuaugagcgu gaacgaaucu ugcuauaaau acggacagac ccuagaccug     1500

ucaaagaaua guauuuucuu uguuaaaagc uccgauuucc aacaucucuc uuuccugaag     1560

ugucuuaacu ugucggguaa ucugaucagc cagacguuaa acggcuccga auuucagccu     1620

cucgccgagc ugcgcuaccu ugacuucuca aauaacagac uggauuugcu ccacaguacu     1680

gcauuugagg aacugcacaa gcuagaggug cuggacaucu cuagcaauuc ccauuauuuc     1740

cagucagaag ggauuacaca caugcucaac uuuaccaaaa accugaaggu ccuucaaaaa     1800

uugaugauga augauaacga cauaaguucu uccacuagca ggacaaugga gagcgaaucu     1860

cugcggaccu uagaguuccg aggaaaucau cucgacgugc uguggcgcga aggcgauaac     1920

agauaccuuc agcuguuuaa gaaucuacuc aaacuggagg aguuggacau cuccaagaac     1980

ucacugaguu ucuuaccaag cgguguauuu gaugggaugc cgcccaaucu caagaaccug     2040

ucgcuugcua aaaauggacu gaaguccuuc ucuuggaaaa aguugcagug ccucaaaaac     2100

cuggaaacgc uagaccugag ccacaaucag cuuaccacag uuccugagag gcucucaaac     2160

uguagucggu cccugaagaa uuugauucug aaaaacaauc aaauccgcuc uuuaacuaag     2220

uauuuucucc aggaugccuu ccagcugaga uaccuugacc ugagcuccaa caagauucag     2280

augauccaaa agaccucauu uccagaaaac guguugaaua accucaagau gcugcuacug     2340

caucacaaua gguuccuuug cacaugugau gcggucuggu ucguguggug ggucaaccac     2400

acugagguga ccauacccua ucucgccaca gacguuaccu gcgugggccc uggcgcacau     2460

aaagggcaga gcguaaucag ucuggauuug uacacuugug aguuagaccu gacgaaucuc     2520

auucuguuuu cucuuuccau cagcgucucg cuguucuuga uggugaugau gacagcuuca     2580

caccuauauu uuugggaugu uugguacauu uaccauuucu gcaaggccaa aaucaaggga     2640

uaucagcguc ugauaucucc agacuguugc uacgaugcuu uuauugugua ugacaccaag     2700

gaccccgccg ucacugaaug ggugcucgca gagcugguag ccaaacuuga agauccgcgg     2760

gagaagcacu ucaacuuaug ucuggaggaa cgagacuggc ucccugguca accaguguug     2820

gagaaucuga gucaguccau ccagcucagc aaaaagaccg uuuuugucau gacagauaaa     2880

uacgcuaaga ccgaaaacuu caagauugcg uuuuaucugu cucaccagag acuuauggac     2940

gagaaagugg augugaucau acugaucuuc uuggaaaagc ccuuucaaaa gagcaaguuc     3000

cuacagcuga ggaaacgccu cugcggcucc ucagucuuag aguggccuac uaauccccag     3060

gcacauccau acuucuggca gugccugaag aacgcccuug cuacagacaa ucacguugcc     3120

uauagucaag uguuuaagga aacgguguga                                      3150


<210>  9772
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR7__Homo_sapiens__AAZ99025

<400>  9772
augguguucc ccauguggac ccugaagaga cugauccuga uccuguucaa caucauccug       60

aucagcaagc ugcugggcgc cagaugguuc cccaagaccc ugcccugcga cgugacccug      120

gacgugccca agaaccacgu gaucguggac ugcaccgaca agcaccugac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccug acccugacca ucaaccacau ccccgacauc      240

agccccgcca gcuuccacag acuggaccac cugguggaga ucgacuucag augcaacugc      300

gugcccaucc cccugggcag caagaacaac augugcauca agagacugca gaucaagccc      360

agaagcuuca gcggccugac cuaccugaag agccuguacc uggacggcaa ccagcugcug      420

gagauccccc agggccugcc ccccagccug cagcugcuga gccuggaggc caacaacauc      480

uucagcauca gaaaggagaa ccugaccgag cuggccaaca ucgagauccu guaccugggc      540

cagaacugcu acuacagaaa ccccugcuac gugagcuaca gcaucgagaa ggacgccuuc      600

cugaaccuga ccaagcugaa ggugcugagc cugaaggaca acaacgugac cgccgugccc      660

accgugcugc ccagcacccu gaccgagcug uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccugaaccag cugcagaucc uggaccugag cggcaacugc      780

cccagaugcu acaacgcccc cuuccccugc gcccccugca agaacaacag cccccugcag      840

auccccguga acgccuucga cgcccugacc gagcugaagg ugcugagacu gcacagcaac      900

agccugcagc acgugccccc cagaugguuc aagaacauca acaagcugca ggagcuggac      960

cugagccaga acuuccuggc caaggagauc ggcgacgcca aguuccugca cuuccugccc     1020

agccugaucc agcuggaccu gagcuucaac uucgagcugc agguguacag agccagcaug     1080

aaccugagcc aggccuucag cagccugaag agccugaaga uccugagaau cagaggcuac     1140

guguucaagg agcugaagag cuucaaccug agcccccugc acaaccugca gaaccuggag     1200

gugcuggacc ugggcaccaa cuucaucaag aucgccaacc ugagcauguu caagcaguuc     1260

aagagacuga aggugaucga ccugagcgug aacaagauca gccccagcgg cgacagcagc     1320

gaggugggcu ucugcagcaa cgugagaacc agcguggaga gcuacgagcc ccaggugcug     1380

gagcagcugc acuacuucag auacgacaag uacgccagaa gcugcagauu caagaacaag     1440

gaggccagcu ucaugagcgu gaacgagagc ugcuacaagu acggccagac ccuggaccug     1500

agcaagaaca gcaucuucuu cgugaagagc agcgacuucc agcaccugag cuuccugaag     1560

ugccugaacc ugagcggcaa ccugaucagc cagacccuga acggcagcga guuccagccc     1620

cuggccgagc ugagauaccu ggacuucagc aacaacagac uggaccugcu gcacagcacc     1680

gccuucgagg agcugcacaa gcuggaggug cuggacauca gcagcaacag ccacuacuuc     1740

cagagcgagg gcaucaccca caugcugaac uucaccaaga accugaaggu gcugcagaag     1800

cugaugauga acgacaacga caucagcagc agcaccagca gaaccaugga gagcgagagc     1860

cugagaaccc uggaguucag aggcaaccac cuggacgugc uguggagaga gggcgacaac     1920

agauaccugc agcuguucaa gaaccugcug aagcuggagg agcuggacau cagcaagaac     1980

agccugagcu uccugcccag cggcguguuc gacggcaugc cccccaaccu gaagaaccug     2040

agccuggcca agaacggccu gaagagcuuc agcuggaaga agcugcagug ccugaagaac     2100

cuggagaccc uggaccugag ccacaaccag cugaccaccg ugcccgagag acugagcaac     2160

ugcagcagaa gccugaagaa ccugauccug aagaacaacc agaucagaag ccugaccaag     2220

uacuuccugc aggacgccuu ccagcugaga uaccuggacc ugagcagcaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac gugcugaaca accugaagau gcugcugcug     2340

caccacaaca gauuccugug caccugcgac gccguguggu ucguguggug ggugaaccac     2400

accgagguga ccauccccua ccuggccacc gacgugaccu gcgugggccc cggcgcccac     2460

aagggccaga gcgugaucag ccuggaccug uacaccugcg agcuggaccu gaccaaccug     2520

auccuguuca gccugagcau cagcgugagc cuguuccuga uggugaugau gaccgccagc     2580

caccuguacu ucugggacgu gugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagagac ugaucagccc cgacugcugc uacgacgccu ucaucgugua cgacaccaag     2700

gaccccgccg ugaccgagug ggugcuggcc gagcuggugg ccaagcugga ggaccccaga     2760

gagaagcacu ucaaccugug ccuggaggag agagacuggc ugcccggcca gcccgugcug     2820

gagaaccuga gccagagcau ccagcugagc aagaagaccg uguucgugau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccuga gccaccagag acugauggac     2940

gagaaggugg acgugaucau ccugaucuuc cuggagaagc ccuuccagaa gagcaaguuc     3000

cugcagcuga gaaagagacu gugcggcagc agcgugcugg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccugaag aacgcccugg ccaccgacaa ccacguggcc     3120

uacagccagg uguucaagga gaccguguga                                      3150


<210>  9773
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR7__Homo_sapiens__AAZ99025

<400>  9773
augguguucc ccauguggac ccugaagaga cucauccuga uucuuuuuaa caucauucug       60

aucagcaaac uccugggcgc ccggugguuc ccuaagacac uuccgugcga cgucacgcug      120

gauguuccca aaaaucacgu gauuguggac uguaccgaua agcaucucac agagaucccu      180

gggggaaucc ccaccaacac aaccaaucug acacugacca uuaaccacau cccugacauu      240

ucccccgcuu cuuuucaucg ccucgaucac cuggucgaaa ucgacuucag augcaauugu      300

gugccuauuc cgcuuggcag caaaaacaau augugcauca agcggcugca gauuaagccc      360

cgcuccuuuu cugggcucac guaccugaaa agccuuuauc uggauggaaa ccaacuccug      420

gagaucccuc agggccugcc cccuucccuc cagcugcuuu cucuggaagc caauaacauc      480

uucagcauua gaaaggagaa ucucaccgaa cuggcgaaca ucgagauucu uuaccugggg      540

cagaauuguu auuaccggaa ccccugcuau guuuccuaca gcaucgagaa agacgcuuuu      600

cucaaucuga caaagcugaa agugcucucu cugaaggaua acaacgucac cgccgugccg      660

acaguucuuc cuuccacccu gacggaacuc uaucuguaca auaacaugau ugccaagauc      720

caagaggacg auuucaauaa ccuuaaucag cugcagaucc ucgaccugag cggaaacugu      780

ccccgcugcu acaaugcucc uuuucccugu gcccccugca aaaacaauuc uccucugcag      840

auuccgguga acgcuuucga ugcccucaca gaacugaagg uccuuagacu gcauuccaau      900

agccuccaac acgugccccc ucggugguuu aaaaacauca auaagcugca ggagcuggac      960

cuuucucaga acuuccucgc gaaagagauu ggcgacgcca aguuucugca cuuccugccc     1020

ucccucaucc agcuggaucu uagcuucaau uuugaacugc aaguguaucg cgcuuccaug     1080

aaccucucuc aggccuucag cucccugaaa agccugaaga uucuuagaau ccggggcuac     1140

gucuuuaagg agcucaaauc uuucaaccug uccccucugc auaaucucca gaaccuggaa     1200

guucuugacc uggggaccaa uuuuaucaag auugcuaacc ucagcauguu caaacaauuu     1260

aagcgccuga aagugaucga ucugucugug aauaagauua gccccuccgg agacucuagc     1320

gaggucggcu ucuguuccaa cgugagaaca agcguugaau cuuaugagcc ucaggugcuu     1380

gagcagcucc acuacuuucg guaugauaag uacgcccgcu ccugcagauu caaaaauaag     1440

gaagcgagcu uuaugucugu caacgagucc ugcuauaaau acgggcagac ccuggaccug     1500

agcaaaaauu ccaucuucuu ugugaaaucu agcgauuucc aacaucucuc cuuccugaag     1560

ugucuuaacc ugucuggaaa ucucauuagc cagacccuga acggcuccga auuucagccg     1620

cuggccgagc uucgguaccu cgacuucagc aauaacagac uggaucugcu ccacucuaca     1680

gcuuuugaag aacugcacaa acuugagguu cuggacaucu ccagcaauuc ucauuauuuc     1740

caguccgaag ggauuacgca caugcucaac uuuaccaaga accugaaggu gcugcaaaaa     1800

cuuaugauga augauaacga caucagcucu agcacauccc gcaccaugga gagcgaaucu     1860

cugcggacac ucgaguucag aggaaaucau cuggacgucc ucuggcgcga aggcgauaac     1920

cgguaccugc agcuuuuuaa gaaucugcuc aaacuggagg agcuggacau cuccaagaac     1980

agccuuuccu uccugcccuc uggcguguuu gaugggaugc cucccaaucu caagaaccug     2040

agccucgcca aaaauggacu gaaguccuuc ucuuggaaaa agcugcagug ccuuaaaaac     2100

cucgaaaccc uggaccugag ccacaaucag cuuacgacag ucccugagag acuguccaac     2160

uguucucgca gccucaagaa ucugauucuc aaaaacaauc aaauccgguc ccugaccaag     2220

uauuuucuuc aggaugcuuu ccagcugaga uaccuggacc ucagcucuaa caagauucag     2280

augauccaaa agaccuccuu ucccgaaaac gugcugaaua accuuaagau gcugcuccug     2340

caucacaauc gcuuccucug cacaugugau gccguuuggu ucguguggug ggucaaccac     2400

accgagguga caauuccgua ucuggccacg gacguuaccu gcgugggccc uggggcucau     2460

aaaggacaga gcgucaucuc ucuugaucug uacacaugug agcuggaccu caccaaucug     2520

auccuguuuu cccuuagcau uucugugucc cucuuccuga uggugaugau gacagcgagc     2580

caccucuauu uuugggaugu uugguacauc uaccauuucu gcaaggccaa aauuaagggc     2640

uaucagcggc ugaucucccc cgacuguugc uacgaugcuu uuauugucua ugacaccaag     2700

gaccccgccg ugacggaaug ggugcuugcc gagcuggucg cuaaacugga agauccuaga     2760

gagaagcacu ucaaccucug ucuggaggag cgcgacuggc uuccggggca acccgugcug     2820

gagaaucuca gccagucuau ccagcugagc aaaaagaccg uuuuugugau gacagauaaa     2880

uacgccaaga ccgaaaacuu caagaucgcg uuuuaucucu cccaccagcg gcugauggac     2940

gagaaagucg augugauuau ccuuauuuuc cuggaaaagc cuuuucaaaa aucuaaguuc     3000

cugcagcuca gaaaacggcu gugcggaagc uccguucuug aguggcccac aaauccucag     3060

gcucaucccu acuucuggca gugccugaag aacgcccucg ccaccgacaa ucacguggcu     3120

uauucucaag ucuuuaagga aacgguguga                                      3150


<210>  9774
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__Q9NYK1

<400>  9774

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys 
        995                 1000                1005            


Gly Ser Ser Val Leu Glu Trp Pro Thr Asn Pro Gln Ala His Pro Tyr 
    1010                1015                1020                


Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala 
1025                1030                1035                1040


Tyr Ser Gln Val Phe Lys Glu Thr Val 
                1045                


<210>  9775
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR7__Homo_sapiens__AAF60188

<400>  9775
augguguuuc caauguggac acugaagaga caaauucuua uccuuuuuaa cauaauccua       60

auuuccaaac uccuuggggc uagaugguuu ccuaaaacuc ugcccuguga ugucacucug      120

gauguuccaa agaaccaugu gaucguggac ugcacagaca agcauuugac agaaauuccu      180

ggagguauuc ccacgaacac cacgaaccuc acccucacca uuaaccacau accagacauc      240

uccccagcgu ccuuucacag acuggaccau cugguagaga ucgauuucag augcaacugu      300

guaccuauuc cacugggguc aaaaaacaac augugcauca agaggcugca gauuaaaccc      360

agaagcuuua guggacucac uuauuuaaaa ucccuuuacc uggauggaaa ccagcuacua      420

gagauaccgc agggccuccc gccuagcuua cagcuucuca gccuugaggc caacaacauc      480

uuuuccauca gaaaagagaa ucuaacagaa cuggccaaca uagaaauacu cuaccugggc      540

caaaacuguu auuaucgaaa uccuuguuau guuucauauu caauagagaa agaugccuuc      600

cuaaacuuga caaaguuaaa agugcucucc cugaaagaua acaaugucac agccgucccu      660

acuguuuugc caucuacuuu aacagaacua uaucucuaca acaacaugau ugcaaaaauc      720

caagaagaug auuuuaauaa ccucaaccaa uuacaaauuc uugaccuaag uggaaauugc      780

ccucguuguu auaaugcccc auuuccuugu gcgccgugua aaaauaauuc uccccuacag      840

aucccuguaa augcuuuuga ugcgcugaca gaauuaaaag uuuuacgucu acacaguaac      900

ucucuucagc augugccccc aagaugguuu aagaacauca acaaacucca ggaacuggau      960

cugucccaaa acuucuuggc caaagaaauu ggggaugcua aauuucugca uuuucucccc     1020

agccucaucc aauuggaucu gucuuucaau uuugaacuuc aggucuaucg ugcaucuaug     1080

aaucuaucac aagcauuuuc uucacugaaa agccugaaaa uucugcggau cagaggauau     1140

gucuuuaaag aguugaaaag cuuuaaccuc ucgccauuac auaaucuuca aaaucuugaa     1200

guucuugauc uuggcacuaa cuuuauaaaa auugcuaacc ucagcauguu uaaacaauuu     1260

aaaagacuga aagucauaga ucuuucagug aauaaaauau caccuucagg agauucaagu     1320

gaaguuggcu ucugcucaaa ugccagaacu ucuguagaaa guuaugaacc ccagguccug     1380

gaacaauuac auuauuucag auaugauaag uaugcaagga guugcagauu caaaaacaaa     1440

gaggcuucuu ucaugucugu uaaugaaagc ugcuacaagu augggcagac cuuggaucua     1500

aguaaaaaua guauauuuuu ugucaagucc ucugauuuuc agcaucuuuc uuuccucaaa     1560

ugccugaauc ugucaggaaa ucucauuagc caaacucuua auggcaguga auuccaaccu     1620

uuagcagagc ugagauauuu ggacuucucc aacaaccggc uugauuuacu ccauucaaca     1680

gcauuugaag agcuucacaa acuggaaguu cuggauauaa gcaguaauag ccauuauuuu     1740

caaucagaag gaauuacuca uaugcuaaac uuuaccaaga accuaaaggu ucugcagaaa     1800

cugaugauga acgacaauga caucucuucc uccaccagca ggaccaugga gagugagucu     1860

cuuagaacuc uggaauucag aggaaaucac uuagauguuu uauggagaga aggugauaac     1920

agauacuuac aauuauucaa gaaucugcua aaauuagagg aauuagacau cucuaaaaau     1980

ucccuaaguu ucuugccuuc uggaguuuuu gaugguaugc cuccaaaucu aaagaaucuc     2040

ucuuuggcca aaaaugggcu caaaucuuuc aguuggaaga aacuccagug ucuaaagaac     2100

cuggaaacuu uggaccucag ccacaaccaa cugaccacug ucccugagag auuauccaac     2160

uguuccagaa gccucaagaa ucugauucuu aagaauaauc aaaucaggag ucugacgaag     2220

uauuuucuac aagaugccuu ccaguugcga uaucuggauc ucagcucaaa uaaaauccag     2280

augauccaaa agaccagcuu cccagaaaau guccucaaca aucugaagau guugcuuuug     2340

caucauaauc gguuucugug caccugugau gcuguguggu uugucuggug gguuaaccau     2400

acggagguga cuauuccuua ccuggccaca gaugugacuu guguggggcc aggagcacac     2460

aagggccaaa gugugaucuc ccuggaucug uacaccugug aguuagaucu gacuaaccug     2520

auucuguucu cacuuuccau aucuguaucu cucuuucuca uggugaugau gacagcaagu     2580

caccucuauu ucugggaugu gugguauauu uaccauuucu guaaggccaa gauaaagggg     2640

uaucagcguc uaauaucacc agacuguugc uaugaugcuu uuauugugua ugacacuaaa     2700

gacccagcug ugaccgagug gguuuuggcu gagcuggugg ccaaacugga agacccaaga     2760

gagaaacauu uuaauuuaug ucucgaggaa agggacuggu uaccagggca gccaguucug     2820

gaaaaccuuu cccagagcau acagcuuagc aaaaagacag uguuugugau gacagacaag     2880

uaugcaaaga cugaaaauuu uaagauagca uuuuacuugu cccaucagag gcucauggau     2940

gaaaaaguug augugauuau cuugauauuu cuugagaagc ccuuucagaa guccaaguuc     3000

cuccagcucc ggaaaaggcu cugugggagu ucuguccuug aguggccaac aaacccgcaa     3060

gcucacccau acuucuggca gugucuaaag aacgcccugg ccacagacaa ucauguggcc     3120

uauagucagg uguucaagga aacggucuag                                      3150


<210>  9776
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR7__Homo_sapiens__AAF60188

<400>  9776
augguguucc ccauguggac ccugaagcgc cagauccuca uccuguucaa caucauccug       60

aucagcaagc uccugggcgc ccggugguuc ccgaagaccc ugcccugcga cgucacgcuc      120

gacgugccca agaaccacgu gaucgucgac ugcaccgaca agcaccugac cgagaucccc      180

gggggcaucc cgaccaacac gaccaaccug acccucacca ucaaccacau ccccgacauc      240

ucccccgcca gcuuccaccg ccuggaccac cugguggaga ucgacuuccg gugcaacugc      300

gugcccaucc cgcucggguc caagaacaac augugcauca agcgccugca gaucaagccc      360

cggagcuucu ccggccugac guaccucaag agccuguacc uggacgggaa ccagcuccug      420

gagauccccc agggccugcc cccgucccuc cagcugcuga gccucgaggc gaacaacauc      480

uucuccaucc gcaaggagaa ccugaccgag cuggccaaca ucgagauccu cuaccugggc      540

cagaacugcu acuaccggaa ccccugcuac gucagcuacu ccaucgagaa ggacgccuuc      600

cugaaccuca ccaagcugaa ggugcugagc cucaaggaca acaacgugac cgccgucccc      660

acggugcugc ccuccacccu gaccgagcuc uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccugaaccag cuccagaucc uggaccugag cgggaacugc      780

ccgcgcugcu acaacgcgcc cuuccccugc gcccccugca agaacaacuc cccgcuccag      840

auccccguga acgccuucga cgcccugacc gagcugaagg uccuccggcu gcacagcaac      900

ucccugcagc acgugccgcc ccgcugguuc aagaacauca acaagcucca ggagcuggac      960

cugagccaga acuuccuggc gaaggagauc ggcgacgcca aguuccucca cuuccugccc     1020

ucccugaucc agcucgaccu gagcuucaac uucgagcucc agguguaccg ggccagcaug     1080

aaccucuccc aggccuucag cucccucaag agccugaaga uccugcgcau ccggggguac     1140

gucuucaagg agcugaaguc cuucaaccug agcccccucc acaaccugca gaaccuggag     1200

gugcucgacc ugggcacgaa cuucaucaag aucgccaacc uguccauguu caagcaguuc     1260

aagcgccuca aggugaucga ccugagcguc aacaagaucu cccccagcgg ggacuccagc     1320

gaggugggcu ucugcuccaa cgcgcggacc agcguggagu ccuacgagcc ccagguccug     1380

gagcagcucc acuacuuccg cuacgacaag uacgcccgga gcugccgcuu caagaacaag     1440

gaggccuccu ucaugagcgu gaacgagucc ugcuacaagu acggccagac ccuggaccug     1500

agcaagaaca gcaucuucuu cgugaagucc agcgacuucc agcaccucuc cuuccugaag     1560

ugccugaacc ucagcgggaa ccugaucucc cagacccuga acggcagcga guuccagccg     1620

cucgccgagc ugcgguaccu ggacuucucc aacaaccgcc ucgaccugcu gcacagcacg     1680

gccuucgagg agcuccacaa gcuggagguc cuggacaucu ccagcaacuc ccacuacuuc     1740

cagagcgagg ggaucaccca caugcucaac uucaccaaga accugaaggu gcugcagaag     1800

cucaugauga acgacaacga caucuccagc uccaccagcc ggacgaugga guccgagagc     1860

cugcgcaccc uggaguuccg cggcaaccac cucgacgucc uguggcggga gggcgacaac     1920

cgcuaccugc agcuguucaa gaaccugcug aagcucgagg agcuggacau cagcaagaac     1980

ucccugagcu uccuccccuc cgggguguuc gacggcaugc ccccgaaccu gaagaaccug     2040

agccucgcga agaacgggcu gaaguccuuc agcuggaaga agcugcagug ccucaagaac     2100

cuggagaccc uggaccucuc ccacaaccag cugaccacgg ugcccgagcg gcugagcaac     2160

ugcucccgca gccucaagaa ccugauccug aagaacaacc agauccgguc ccucaccaag     2220

uacuuccugc aggacgccuu ccagcugcgc uaccucgacc ugagcuccaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac guccugaaca accucaagau gcugcugcuc     2340

caccacaacc gguuccugug cacgugcgac gccguguggu ucguguggug ggucaaccac     2400

accgagguga ccauccccua ccuggccacc gacgugaccu gcgucggccc gggggcccac     2460

aagggccagu ccgugaucag ccucgaccug uacacgugcg agcuggaccu caccaaccug     2520

auccuguucu cccucagcau cuccgugagc cuguuccuga uggucaugau gaccgcgagc     2580

caccucuacu ucugggacgu gugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagcgcc ugaucucccc cgacugcugc uacgacgccu ucaucgugua cgacaccaag     2700

gaccccgccg ucaccgagug ggugcuggcc gagcucgugg cgaagcugga ggacccccgg     2760

gagaagcacu ucaaccugug ccuggaggag cgcgacuggc ucccggggca gcccguccug     2820

gagaaccuga gccaguccau ccagcucagc aagaagacgg uguucgugau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccugu cccaccagcg gcugauggac     2940

gagaaggucg acgugaucau ccucaucuuc cuggagaagc ccuuccagaa guccaaguuc     3000

cugcagcucc gcaagcggcu gugcggcagc agcgugcugg aguggcccac caacccgcag     3060

gcccaccccu acuucuggca gugccucaag aacgcgcugg ccacggacaa ccacgucgcc     3120

uacucccagg uguucaagga gaccguguga                                      3150


<210>  9777
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR7__Homo_sapiens__AAF60188

<400>  9777
auggucuucc ccauguggac ccucaagcgc cagauccuca uccucuucaa caucauccuc       60

aucuccaagc uccucggcgc ccgcugguuc cccaagaccc uccccugcga cgucacccuc      120

gacgucccca agaaccacgu caucgucgac ugcaccgaca agcaccucac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccuc acccucacca ucaaccacau ccccgacauc      240

ucccccgccu ccuuccaccg ccucgaccac cucgucgaga ucgacuuccg cugcaacugc      300

guccccaucc cccucggcuc caagaacaac augugcauca agcgccucca gaucaagccc      360

cgcuccuucu ccggccucac cuaccucaag ucccucuacc ucgacggcaa ccagcuccuc      420

gagauccccc agggccuccc ccccucccuc cagcuccucu cccucgaggc caacaacauc      480

uucuccaucc gcaaggagaa ccucaccgag cucgccaaca ucgagauccu cuaccucggc      540

cagaacugcu acuaccgcaa ccccugcuac gucuccuacu ccaucgagaa ggacgccuuc      600

cucaaccuca ccaagcucaa gguccucucc cucaaggaca acaacgucac cgccgucccc      660

accguccucc ccuccacccu caccgagcuc uaccucuaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccucaaccag cuccagaucc ucgaccucuc cggcaacugc      780

ccccgcugcu acaacgcccc cuuccccugc gcccccugca agaacaacuc cccccuccag      840

auccccguca acgccuucga cgcccucacc gagcucaagg uccuccgccu ccacuccaac      900

ucccuccagc acgucccccc ccgcugguuc aagaacauca acaagcucca ggagcucgac      960

cucucccaga acuuccucgc caaggagauc ggcgacgcca aguuccucca cuuccucccc     1020

ucccucaucc agcucgaccu cuccuucaac uucgagcucc aggucuaccg cgccuccaug     1080

aaccucuccc aggccuucuc cucccucaag ucccucaaga uccuccgcau ccgcggcuac     1140

gucuucaagg agcucaaguc cuucaaccuc uccccccucc acaaccucca gaaccucgag     1200

guccucgacc ucggcaccaa cuucaucaag aucgccaacc ucuccauguu caagcaguuc     1260

aagcgccuca aggucaucga ccucuccguc aacaagaucu cccccuccgg cgacuccucc     1320

gaggucggcu ucugcuccaa cgcccgcacc uccgucgagu ccuacgagcc ccagguccuc     1380

gagcagcucc acuacuuccg cuacgacaag uacgcccgcu ccugccgcuu caagaacaag     1440

gaggccuccu ucauguccgu caacgagucc ugcuacaagu acggccagac ccucgaccuc     1500

uccaagaacu ccaucuucuu cgucaagucc uccgacuucc agcaccucuc cuuccucaag     1560

ugccucaacc ucuccggcaa ccucaucucc cagacccuca acggcuccga guuccagccc     1620

cucgccgagc uccgcuaccu cgacuucucc aacaaccgcc ucgaccuccu ccacuccacc     1680

gccuucgagg agcuccacaa gcucgagguc cucgacaucu ccuccaacuc ccacuacuuc     1740

caguccgagg gcaucaccca caugcucaac uucaccaaga accucaaggu ccuccagaag     1800

cucaugauga acgacaacga caucuccucc uccaccuccc gcaccaugga guccgagucc     1860

cuccgcaccc ucgaguuccg cggcaaccac cucgacgucc ucuggcgcga gggcgacaac     1920

cgcuaccucc agcucuucaa gaaccuccuc aagcucgagg agcucgacau cuccaagaac     1980

ucccucuccu uccuccccuc cggcgucuuc gacggcaugc cccccaaccu caagaaccuc     2040

ucccucgcca agaacggccu caaguccuuc uccuggaaga agcuccagug ccucaagaac     2100

cucgagaccc ucgaccucuc ccacaaccag cucaccaccg uccccgagcg ccucuccaac     2160

ugcucccgcu cccucaagaa ccucauccuc aagaacaacc agauccgcuc ccucaccaag     2220

uacuuccucc aggacgccuu ccagcuccgc uaccucgacc ucuccuccaa caagauccag     2280

augauccaga agaccuccuu ccccgagaac guccucaaca accucaagau gcuccuccuc     2340

caccacaacc gcuuccucug caccugcgac gccgucuggu ucgucuggug ggucaaccac     2400

accgagguca ccauccccua ccucgccacc gacgucaccu gcgucggccc cggcgcccac     2460

aagggccagu ccgucaucuc ccucgaccuc uacaccugcg agcucgaccu caccaaccuc     2520

auccucuucu cccucuccau cuccgucucc cucuuccuca uggucaugau gaccgccucc     2580

caccucuacu ucugggacgu cugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagcgcc ucaucucccc cgacugcugc uacgacgccu ucaucgucua cgacaccaag     2700

gaccccgccg ucaccgagug gguccucgcc gagcucgucg ccaagcucga ggacccccgc     2760

gagaagcacu ucaaccucug ccucgaggag cgcgacuggc uccccggcca gcccguccuc     2820

gagaaccucu cccaguccau ccagcucucc aagaagaccg ucuucgucau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccucu cccaccagcg ccucauggac     2940

gagaaggucg acgucaucau ccucaucuuc cucgagaagc ccuuccagaa guccaaguuc     3000

cuccagcucc gcaagcgccu cugcggcucc uccguccucg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccucaag aacgcccucg ccaccgacaa ccacgucgcc     3120

uacucccagg ucuucaagga gaccgucuga                                      3150


<210>  9778
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR7__Homo_sapiens__AAF60188

<400>  9778
augguguucc ccauguggac ccugaagaga cagauccuca uucuuuuuaa cauaauccug       60

auuagcaaau uguuaggcgc caggugguuc ccuaagacac ugccaugcga cgucacucua      120

gauguuccga aaaaucacgu gaucguagac uguacggaua agcaucucac cgagauuccc      180

gggggaaucc cuacaaacac uaccaaucug acacuuacca uaaaccacau cccagacauu      240

ucccccgcuu cuuuucaucg gcuggaucac uugguggaaa ucgacuuccg cugcaauugu      300

gucccuauuc cacucgguag caaaaacaau augugcauca agcgacugca aauaaagccc      360

cguaguuuua gcggccugac uuaccucaaa uccuuauauc uggaugggaa ccagcuuuug      420

gagauuccuc agggacugcc accgucucua cagcuccugu cgcuugaagc aaauaacauc      480

uucucaauua gaaaggagaa ucugacagaa uuggccaaca ucgagauccu cuaccugggc      540

caaaauuguu auuacaggaa ccccugcuau gugagcuaca guauugagaa agacgcguuu      600

uuaaaucuga ccaagcucaa aguucuuucc cugaaggaua acaacgugac ggcugucccu      660

acuguguugc caucuacccu aacagaacug uaucucuaca auaacaugau agccaagauc      720

caggaggacg auuucaauaa ccugaaucag cuucagauuc uggacuugag cgguaacugu      780

ccccggugcu acaaugcacc uuuuccaugu gcccccugca aaaacaauuc cccgcuccaa      840

aucccuguaa acgcuuucga ugcacugacu gaauuaaagg uucugcgccu acauucaaau      900

agucuccagc acgugccccc aagaugguuu aaaaacauaa auaagcugca ggagcuugac      960

uugagccaga acuuccuggc caaagagauu ggggacgcua aguuucucca cuuccugccu     1020

ucucuuaucc aacuggauuu guccuucaau uuugaacucc aggucuauag ggccucaaug     1080

aaccugagcc aggcguucag uucuuuaaaa ucccugaaga uccuacggau ucgcggauac     1140

guguuuaagg agcucaaauc auucaaccug ucgccccuuc auaauuugca aaaccuggaa     1200

gugcucgacc ugggcaccaa uuuuaucaag auugcaaacu uaucuauguu caaacaguuu     1260

aagcgacuga aagucauaga ucuuuccguu aauaagaucu caccaagugg cgacagcucc     1320

gagguggggu ucuguucuaa cgccagaaca agcguagaau cauaugagcc ccagguguug     1380

gagcagcucc acuacuuuag guaugauaag uacgcucgga guugccguuu caaaaauaag     1440

gaagccuccu uuaugagcgu caacgagucu ugcuauaaau acggacaaac ccuggaccua     1500

ucaaagaaua guauuuucuu ugugaaaagc uccgauuucc agcaucuguc uuuccucaag     1560

ugucugaacc uuucggguaa uuugaucagc cagacgcuga acggcuccga auuucagccu     1620

uuagcagagc uccgcuaccu ggacuucuca aauaacagac uugaucuguu gcacaguacu     1680

gcuuuugaag aacuccacaa gcuggagguu cuagacaucu cuagcaauuc ccauuauuuc     1740

caaucagaag ggauuacaca caugcugaac uuuaccaaaa accucaaggu gcugcagaaa     1800

cuuaugauga augauaacga cauaaguucu uccacuagca ggacaaugga gagcgaaucu     1860

uugcggaccc uggaguuccg aggaaaucau uuagacgucc ucuggcgcga aggcgauaac     1920

agauaccugc agcuuuuuaa gaaucugcua aaacucgagg agcuggacau cuccaagaac     1980

ucauugaguu uccugccaag cgguguguuu gaugggaugc cgcccaauuu aaagaaccuc     2040

ucgcuggcca aaaauggacu uaaguccuuc ucuuggaaaa agcugcagug cuugaaaaac     2100

cucgaaacgc uggaccuaag ccacaaucaa cugaccacag uaccugagag gcuuucaaac     2160

uguagucggu cccucaagaa ucugauuuug aaaaacaauc agauccgcuc ucugacuaag     2220

uacuuuuuac aggaugcguu ccagcucaga uaucuggacc uuagcuccaa caagauucaa     2280

augauccaga aaaccucauu uccagaaaac guucugaaua acuugaagau gcuccugcua     2340

caucacaaua gguuccugug cacaugugau gccguguggu ucgucuggug ggugaaccac     2400

acugagguca ccauacccua ucuugcaaca gacgugaccu gcguuggccc uggcgcucau     2460

aaagggcaga gcgugaucag ucucgaucug uacacuugug aguuggacuu aacgaaucug     2520

auucucuuuu cucuguccau cagcguaucg cuuuuccuga uggucaugau gacagccuca     2580

cacuuguauu uuugggaugu gugguacauu uaccauuucu gcaaggcuaa aaucaaggga     2640

uaucaacguc uaauaucucc agacuguugc uacgaugccu uuauuguuua ugacaccaag     2700

gaccccgcag ugacugaaug gguccuggcc gagcucgugg cuaaacugga agauccgcgg     2760

gagaagcacu ucaaccuuug uuuagaggag cgagacuggc ugccugguca gccaguacuc     2820

gagaauuuga gucaguccau ccagcugagc aaaaagaccg uguuuguuau gacagauaaa     2880

uacgcgaaga ccgaaaacuu caagauugca uuuuaucucu cucaccaaag acugauggac     2940

gagaaagucg augugaucau acuuaucuuc cuggaaaagc ccuuucagaa aagcaaguuc     3000

uugcagcuaa ggaaacgccu gugcggcucc ucagugcucg aguggccuac uaauccccag     3060

gcccauccau acuucuggca augcuuaaag aacgcucugg ccacagacaa ucacgucgca     3120

uauagucagg uuuuuaagga aacgguguga                                      3150


<210>  9779
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR7__Homo_sapiens__AAF60188

<400>  9779
augguguucc ccauguggac ccugaagaga cagauccuga uccuguucaa caucauccug       60

aucagcaagc ugcugggcgc cagaugguuc cccaagaccc ugcccugcga cgugacccug      120

gacgugccca agaaccacgu gaucguggac ugcaccgaca agcaccugac cgagaucccc      180

ggcggcaucc ccaccaacac caccaaccug acccugacca ucaaccacau ccccgacauc      240

agccccgcca gcuuccacag acuggaccac cugguggaga ucgacuucag augcaacugc      300

gugcccaucc cccugggcag caagaacaac augugcauca agagacugca gaucaagccc      360

agaagcuuca gcggccugac cuaccugaag agccuguacc uggacggcaa ccagcugcug      420

gagauccccc agggccugcc ccccagccug cagcugcuga gccuggaggc caacaacauc      480

uucagcauca gaaaggagaa ccugaccgag cuggccaaca ucgagauccu guaccugggc      540

cagaacugcu acuacagaaa ccccugcuac gugagcuaca gcaucgagaa ggacgccuuc      600

cugaaccuga ccaagcugaa ggugcugagc cugaaggaca acaacgugac cgccgugccc      660

accgugcugc ccagcacccu gaccgagcug uaccuguaca acaacaugau cgccaagauc      720

caggaggacg acuucaacaa ccugaaccag cugcagaucc uggaccugag cggcaacugc      780

cccagaugcu acaacgcccc cuuccccugc gcccccugca agaacaacag cccccugcag      840

auccccguga acgccuucga cgcccugacc gagcugaagg ugcugagacu gcacagcaac      900

agccugcagc acgugccccc cagaugguuc aagaacauca acaagcugca ggagcuggac      960

cugagccaga acuuccuggc caaggagauc ggcgacgcca aguuccugca cuuccugccc     1020

agccugaucc agcuggaccu gagcuucaac uucgagcugc agguguacag agccagcaug     1080

aaccugagcc aggccuucag cagccugaag agccugaaga uccugagaau cagaggcuac     1140

guguucaagg agcugaagag cuucaaccug agcccccugc acaaccugca gaaccuggag     1200

gugcuggacc ugggcaccaa cuucaucaag aucgccaacc ugagcauguu caagcaguuc     1260

aagagacuga aggugaucga ccugagcgug aacaagauca gccccagcgg cgacagcagc     1320

gaggugggcu ucugcagcaa cgccagaacc agcguggaga gcuacgagcc ccaggugcug     1380

gagcagcugc acuacuucag auacgacaag uacgccagaa gcugcagauu caagaacaag     1440

gaggccagcu ucaugagcgu gaacgagagc ugcuacaagu acggccagac ccuggaccug     1500

agcaagaaca gcaucuucuu cgugaagagc agcgacuucc agcaccugag cuuccugaag     1560

ugccugaacc ugagcggcaa ccugaucagc cagacccuga acggcagcga guuccagccc     1620

cuggccgagc ugagauaccu ggacuucagc aacaacagac uggaccugcu gcacagcacc     1680

gccuucgagg agcugcacaa gcuggaggug cuggacauca gcagcaacag ccacuacuuc     1740

cagagcgagg gcaucaccca caugcugaac uucaccaaga accugaaggu gcugcagaag     1800

cugaugauga acgacaacga caucagcagc agcaccagca gaaccaugga gagcgagagc     1860

cugagaaccc uggaguucag aggcaaccac cuggacgugc uguggagaga gggcgacaac     1920

agauaccugc agcuguucaa gaaccugcug aagcuggagg agcuggacau cagcaagaac     1980

agccugagcu uccugcccag cggcguguuc gacggcaugc cccccaaccu gaagaaccug     2040

agccuggcca agaacggccu gaagagcuuc agcuggaaga agcugcagug ccugaagaac     2100

cuggagaccc uggaccugag ccacaaccag cugaccaccg ugcccgagag acugagcaac     2160

ugcagcagaa gccugaagaa ccugauccug aagaacaacc agaucagaag ccugaccaag     2220

uacuuccugc aggacgccuu ccagcugaga uaccuggacc ugagcagcaa caagauccag     2280

augauccaga agaccagcuu ccccgagaac gugcugaaca accugaagau gcugcugcug     2340

caccacaaca gauuccugug caccugcgac gccguguggu ucguguggug ggugaaccac     2400

accgagguga ccauccccua ccuggccacc gacgugaccu gcgugggccc cggcgcccac     2460

aagggccaga gcgugaucag ccuggaccug uacaccugcg agcuggaccu gaccaaccug     2520

auccuguuca gccugagcau cagcgugagc cuguuccuga uggugaugau gaccgccagc     2580

caccuguacu ucugggacgu gugguacauc uaccacuucu gcaaggccaa gaucaagggc     2640

uaccagagac ugaucagccc cgacugcugc uacgacgccu ucaucgugua cgacaccaag     2700

gaccccgccg ugaccgagug ggugcuggcc gagcuggugg ccaagcugga ggaccccaga     2760

gagaagcacu ucaaccugug ccuggaggag agagacuggc ugcccggcca gcccgugcug     2820

gagaaccuga gccagagcau ccagcugagc aagaagaccg uguucgugau gaccgacaag     2880

uacgccaaga ccgagaacuu caagaucgcc uucuaccuga gccaccagag acugauggac     2940

gagaaggugg acgugaucau ccugaucuuc cuggagaagc ccuuccagaa gagcaaguuc     3000

cugcagcuga gaaagagacu gugcggcagc agcgugcugg aguggcccac caacccccag     3060

gcccaccccu acuucuggca gugccugaag aacgcccugg ccaccgacaa ccacguggcc     3120

uacagccagg uguucaagga gaccguguga                                      3150


<210>  9780
<211>  3150
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR7__Homo_sapiens__AAF60188

<400>  9780
augguguucc ccauguggac ccugaagaga cagauccuca uucuguuuaa caucauucuu       60

aucagcaaac ugcucggcgc ccggugguuc ccuaagacac ugccgugcga cgucacgcuu      120

gauguuccca aaaaucacgu gauuguggac uguaccgaua agcaucugac agagaucccu      180

gggggaaucc ccaccaacac aaccaaucuc acacugacca uuaaccacau cccugacauu      240

ucccccgcuu cuuuucaucg ccuggaucac cucgucgaaa ucgacuucag augcaauugu      300

gugccuauuc cgcugggcag caaaaacaau augugcauca agcggcuuca aauuaagccc      360

cgcuccuuuu cugggcugac guaccucaaa agccuguauc uugauggaaa ccagcugcuc      420

gagaucccuc agggccugcc cccuucccug cagcuccugu cucuugaagc caauaacauc      480

uucagcauua gaaaggagaa ucugaccgaa cucgcgaaca ucgagauucu guaccuuggg      540

caaaauuguu auuaccggaa ccccugcuau guuuccuaca gcaucgagaa agacgcuuuu      600

cugaaucuca caaagcugaa agugcugucu cucaaggaua acaacgucac cgccgugccg      660

acaguucugc cuuccacccu uacggaacug uaucucuaca auaacaugau ugccaagauc      720

caggaggacg auuucaauaa ccugaaucag cuucagaucc uggaccucag cggaaacugu      780

ccccgcugcu acaaugcucc uuuucccugu gcccccugca aaaacaauuc uccucugcaa      840

auuccgguga acgcuuucga ugcccugaca gaacucaagg uccugagacu ucauuccaau      900

agccugcagc acgugccccc ucggugguuu aaaaacauca auaagcucca ggagcuggac      960

cugucucaga acuuccuugc gaaagagauu ggcgacgcca aguuucucca cuuccugccc     1020

ucccugaucc aacucgaucu gagcuucaau uuugaacuuc agguguaucg cgcuuccaug     1080

aaccugucuc aggccuucag cucccucaaa agccugaaga uucugagaau ccggggcuac     1140

gucuuuaagg agcuuaaauc uuucaaccuc uccccucugc auaaucugca aaaccucgaa     1200

guucuggacc uugggaccaa uuuuaucaag auugcuaacc ugagcauguu caaacaguuu     1260

aagcgccuca aagugaucga ucugucugug aauaagauua gccccuccgg agacucuagc     1320

gaggucggcu ucuguuccaa cgccagaaca agcguggaau cuuaugagcc gcagguucug     1380

gagcagcuuc acuacuuucg guaugauaag uacgcgcgcu ccugcagauu caaaaauaag     1440

gaagccagcu uuaugucugu gaacgagucc ugcuauaaau acgggcaaac ccucgaccug     1500

agcaaaaauu ccaucuucuu ugucaagucu agcgauuucc agcaucuguc cuuccucaag     1560

ugucugaacc uuucuggaaa ucugauuagc cagacccuca acggcuccga auuucagccu     1620

cuggcugagc ugcgguaccu ugacuucagc aauaacagac ucgaucugcu gcacucuaca     1680

gccuuugaag aacuccacaa gcuggaggug cuugacaucu ccagcaauuc ucauuauuuc     1740

caauccgaag ggauuacgca caugcugaac uuuaccaaaa accucaaggu ucugcagaaa     1800

cugaugauga augauaacga caucagcucu agcacauccc gcaccaugga gagcgaaucu     1860

cuucggacac uggaguucag aggaaaucau cucgacgugc uguggcgcga aggcgauaac     1920

cgguaccucc agcuguuuaa gaaucuucug aaacucgagg agcuggacau cuccaagaac     1980

agccuguccu uccuucccuc uggcgucuuu gaugggaugc cucccaaucu gaagaaccuc     2040

agccuggcua aaaauggacu caaguccuuc ucuuggaaaa agcugcagug ccuuaaaaac     2100

cuggaaaccc ucgaccugag ccacaaucaa cugacgacag ugccugagag acuuuccaac     2160

uguucucgca gccugaagaa ucucauucug aaaaacaauc agauccgguc ccucaccaag     2220

uauuuucugc aggaugccuu ccagcuuaga uaccuggacc ugagcucuaa caagauucaa     2280

augauccaga aaaccuccuu ucccgaaaac guccucaaua accugaagau gcuucugcuc     2340

caucacaauc gcuuccugug cacaugugau gccguguggu ucguuuggug ggugaaccac     2400

accgagguca caauuccgua ucucgcuacg gacgugaccu gcguuggccc uggggcgcau     2460

aaaggacaga gcgugaucuc ucuggaucuu uacacaugug agcuggaccu gaccaaucuc     2520

auccuguuuu cccuuagcau uucugucucc cuguuccuca uggugaugau gacagccagc     2580

caccuguauu uuugggaugu gugguacauc uaccauuucu gcaaggcuaa aauuaagggc     2640

uaucaacggc ucaucucccc cgacuguugc uacgaugccu uuauuguuua ugacaccaag     2700

gaccccgccg ucacggaaug ggugcuggcu gagcuugugg ccaaacugga agauccuaga     2760

gagaagcacu ucaaccugug ucucgaggag cgcgacuggc ugccggggca gcccguccuu     2820

gagaaucuga gccagucuau ccagcucagc aaaaagaccg uguuuguuau gacagauaaa     2880

uacgcgaaga ccgaaaacuu caagaucgcu uuuuaucugu cccaccaacg gcucauggac     2940

gagaaagugg augucauuau ccugauuuuc cuugaaaagc cuuuucagaa aucuaaguuc     3000

cugcagcuga gaaaacggcu cugcggaagc uccgugcugg aguggcccac aaauccucag     3060

gcccaucccu acuucuggca augccuuaag aacgcccugg cuaccgacaa ucacguugcc     3120

uauucucagg uguuuaagga aacggucuga                                      3150


<210>  9781
<211>  1041
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__Q495P6

<400>  9781

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg 
            20                  25                  30          


Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu 
        35                  40                  45              


Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr 
    50                  55                  60                  


Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn 
65                  70                  75                  80  


Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His 
                85                  90                  95      


Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn 
            100                 105                 110         


Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg 
        115                 120                 125             


Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn 
145                 150                 155                 160 


Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr 
                165                 170                 175     


Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile 
            180                 185                 190         


Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu 
        195                 200                 205             


Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu 
    210                 215                 220                 


Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu 
225                 230                 235                 240 


Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn 
                245                 250                 255     


Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly 
            260                 265                 270         


Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln 
        275                 280                 285             


Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala 
    290                 295                 300                 


Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe 
305                 310                 315                 320 


Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu 
                325                 330                 335     


Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser 
            340                 345                 350         


Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser 
        355                 360                 365             


Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu 
    370                 375                 380                 


Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn 
385                 390                 395                 400 


Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn 
                405                 410                 415     


Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro 
            420                 425                 430         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        435                 440                 445             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    450                 455                 460                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala 
465                 470                 475                 480 


Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile 
                485                 490                 495     


Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu 
            500                 505                 510         


Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala 
        515                 520                 525             


Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe 
    530                 535                 540                 


Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp 
545                 550                 555                 560 


Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His 
                565                 570                 575     


Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser 
            580                 585                 590         


His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys 
        595                 600                 605             


Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp 
    610                 615                 620                 


Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn 
625                 630                 635                 640 


Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn 
                645                 650                 655     


Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn 
            660                 665                 670         


Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro 
        675                 680                 685             


Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr 
    690                 695                 700                 


Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser 
705                 710                 715                 720 


His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser 
                725                 730                 735     


Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn 
            740                 745                 750         


Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu 
        755                 760                 765             


Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg 
    770                 775                 780                 


Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp 
785                 790                 795                 800 


Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser 
                805                 810                 815     


Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe 
            820                 825                 830         


Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala 
        835                 840                 845             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    850                 855                 860                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
865                 870                 875                 880 


Asp Ala Tyr Val Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                885                 890                 895     


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            900                 905                 910         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        915                 920                 925             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    930                 935                 940                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
945                 950                 955                 960 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                965                 970                 975     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            980                 985                 990         


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
        995                 1000                1005            


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
    1010                1015                1020                


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
1025                1030                1035                1040


Tyr 
    


<210>  9782
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__AAI01076

<400>  9782
auggaaaaca uguuccuuca gucgucaaug cugaccugca uuuuccugcu aauaucuggu       60

uccugugagu uaugcgccga agaaaauuuu ucuagaagcu auccuuguga ugagaaaaag      120

caaaaugacu caguuauugc agagugcagc aaucgucgac uacaggaagu uccccaaacg      180

gugggcaaau augugacaga acuagaccug ucugauaauu ucaucacaca cauaacgaau      240

gaaucauuuc aagggcugca aaaucucacu aaaauaaauc uaaaccacaa ccccaaugua      300

cagcaccaga acggaaaucc cgguauacaa ucaaauggcu ugaauaucac agacggggca      360

uuccucaacc uaaaaaaccu aagggaguua cugcuugaag acaaccaguu accccaaaua      420

cccucugguu ugccagaguc uuugacagaa cuuagucuaa uucaaaacaa uauauacaac      480

auaacuaaag agggcauuuc aagacuuaua aacuugaaaa aucucuauuu ggccuggaac      540

ugcuauuuua acaaaguuug cgagaaaacu aacauagaag auggaguauu ugaaacgcug      600

acaaauuugg aguugcuauc acuaucuuuc aauucucuuu cacacgugcc acccaaacug      660

ccaagcuccc uacgcaaacu uuuucugagc aacacccaga ucaaauacau uagugaagaa      720

gauuucaagg gauugauaaa uuuaacauua cuagauuuaa gcgggaacug uccgaggugc      780

uucaaugccc cauuuccaug cgugccuugu gaugguggug cuucaauuaa uauagaucgu      840

uuugcuuuuc aaaacuugac ccaacuucga uaccuaaacc ucucuagcac uucccucagg      900

aagauuaaug cugccugguu uaaaaauaug ccucaucuga aggugcugga ucuugaauuc      960

aacuauuuag ugggagaaau agccucuggg gcauuuuuaa cgaugcugcc ccgcuuagaa     1020

auacuugacu ugucuuuuaa cuauauaaag gggaguuauc cacagcauau uaauauuucc     1080

agaaacuucu cuaaacuuuu gucucuacgg gcauugcauu uaagagguua uguguuccag     1140

gaacucagag aagaugauuu ccagccccug augcagcuuc caaacuuauc gacuaucaac     1200

uuggguauua auuuuauuaa gcaaaucgau uucaaacuuu uccaaaauuu cuccaaucug     1260

gaaauuauuu acuugucaga aaacagaaua ucaccguugg uaaaagauac ccggcagagu     1320

uaugcaaaua guuccucuuu ucaacgucau auccggaaac gacgcucaac agauuuugag     1380

uuugacccac auucgaacuu uuaucauuuc acccguccuu uaauaaagcc acaaugugcu     1440

gcuuauggaa aagccuuaga uuuaagccuc aacaguauuu ucuucauugg gccaaaccaa     1500

uuugaaaauc uuccugacau ugccuguuua aaucugucug caaauagcaa ugcucaagug     1560

uuaaguggaa cugaauuuuc agccauuccu caugucaaau auuuggauuu gacaaacaau     1620

agacuagacu uugauaaugc uagugcucuu acugaauugu ccgacuugga aguucuagau     1680

cucagcuaua auucacacua uuucagaaua gcaggcguaa cacaucaucu agaauuuauu     1740

caaaauuuca caaaucuaaa aguuuuaaac uugagccaca acaacauuua uacuuuaaca     1800

gauaaguaua accuggaaag caagucccug guagaauuag uuuucagugg caaucgccuu     1860

gacauuuugu ggaaugauga ugacaacagg uauaucucca uuuucaaagg ucucaagaau     1920

cugacacguc uggauuuauc ccuuaauagg cugaagcaca ucccaaauga agcauuccuu     1980

aauuugccag cgagucucac ugaacuacau auaaaugaua auauguuaaa guuuuuuaac     2040

uggacauuac uccagcaguu uccucgucuc gaguugcuug acuuacgugg aaacaaacua     2100

cucuuuuuaa cugauagccu aucugacuuu acaucuuccc uucggacacu gcugcugagu     2160

cauaacagga uuucccaccu acccucuggc uuucuuucug aagucaguag ucugaagcac     2220

cucgauuuaa guuccaaucu gcuaaaaaca aucaacaaau ccgcacuuga aacuaagacc     2280

accaccaaau uaucuauguu ggaacuacac ggaaaccccu uugaaugcac cugugacauu     2340

ggagauuucc gaagauggau ggaugaacau cugaauguca aaauucccag acugguagau     2400

gucauuugug ccaguccugg ggaucaaaga gggaagagua uugugagucu ggagcuaaca     2460

acuuguguuu cagaugucac ugcagugaua uuauuuuucu ucacguucuu uaucaccacc     2520

augguuaugu uggcugcccu ggcucaccau uuguuuuacu gggauguuug guuuauauau     2580

aauguguguu uagcuaaggu aaaaggcuac aggucucuuu ccacauccca aacuuucuau     2640

gaugcuuacg uuucuuauga caccaaagau gccucuguua cugacugggu gauaaaugag     2700

cugcgcuacc accuugaaga gagccgagac aaaaacguuc uccuuugucu agaggagagg     2760

gauugggacc cgggauuggc caucaucgac aaccucaugc agagcaucaa ccaaagcaag     2820

aaaacaguau uuguuuuaac caaaaaauau gcaaaaagcu ggaacuuuaa aacagcuuuu     2880

uacuuggcuu ugcagaggcu aauggaugag aacauggaug ugauuauauu uauccugcug     2940

gagccagugu uacagcauuc ucaguauuug aggcuacggc agcggaucug uaagagcucc     3000

auccuccagu ggccugacaa cccgaaggca gaaggcuugu uuuggcaaac ucugagaaau     3060

guggucuuga cugaaaauga uucacgguau aacaauaugu augucgauuc cauuaagcaa     3120

uacuaa                                                                3126


<210>  9783
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR8__Homo_sapiens__AAI01076

<400>  9783
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuccugcu gaucagcggc       60

uccugcgagc ucugcgccga ggagaacuuc agccgcuccu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcucc aaccggcgcc ugcaggaggu cccgcagacc      180

guggggaagu acgugacgga gcuggaccuc agcgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccugca gaaccugacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acgggaaccc cggcauccag agcaacgggc ugaacaucac ggacggcgcg      360

uuccugaacc ucaagaaccu gcgggagcug cuccuggagg acaaccagcu gccccagauc      420

ccguccggcc uccccgagag ccugaccgag cugucccuca uccagaacaa caucuacaac      480

aucaccaagg aggggaucag ccgccugauc aaccugaaga accucuaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacgcug      600

accaaccucg agcugcuguc ccucagcuuc aacucccuga gccacguccc gcccaagcug      660

cccuccagcc uccggaagcu guuccugagc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg ggcucaucaa ccugacccug cucgaccuga gcggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cgugccgugc gacgggggcg ccuccaucaa caucgaccgg      840

uucgccuucc agaaccugac gcagcuccgc uaccugaacc ugagcuccac cagccuccgg      900

aagaucaacg cggccugguu caagaacaug ccccaccuga aggugcugga ccucgaguuc      960

aacuaccugg ucggcgagau cgccuccggg gccuuccuga ccaugcugcc ccgccucgag     1020

auccuggacc ugagcuucaa cuacaucaag ggcuccuacc cccagcacau caacaucagc     1080

cggaacuucu ccaagcuccu gagccugcgc gcgcuccacc uccgggggua cguguuccag     1140

gagcugcgcg aggacgacuu ccagccgcuc augcagcugc ccaaccuguc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accucuccga gaaccggauc agcccccugg ugaaggacac gcgccagucc     1320

uacgccaaca gcuccagcuu ccagcggcac auccgcaagc ggcgcagcac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccggccgc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccugagccug aacuccaucu ucuucaucgg gcccaaccag     1500

uucgagaacc uccccgacau cgcgugccug aaccugagcg ccaacuccaa cgcccagguc     1560

cucagcggca ccgaguucuc cgccaucccg cacgugaagu accuggaccu gacgaacaac     1620

cgccucgacu ucgacaacgc cagcgcgcug accgagcugu ccgaccucga ggugcuggac     1680

cugagcuaca acucccacua cuuccgcauc gccgggguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cucagccaca acaacaucua cacgcugacc     1800

gacaaguaca accuggaguc caagagccuc guggagcugg ucuucuccgg caaccggcug     1860

gacauccucu ggaacgacga cgacaaccgc uacaucagca ucuucaaggg gcugaagaac     1920

cugacccggc ucgaccuguc ccugaaccgc cucaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccucac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacgcucc ugcagcaguu cccccggcug gagcuccugg accugcgcgg caacaagcuc     2100

cuguuccuga ccgacagccu cuccgacuuc accagcuccc ugcggacccu gcuccugagc     2160

cacaaccgca ucucccaccu cccgagcggc uuccuguccg aggugagcuc ccugaagcac     2220

cuggaccuca gcuccaaccu gcugaagacg aucaacaaga gcgcccucga gaccaagacc     2280

accacgaagc uguccaugcu ggagcuccac gggaaccccu ucgagugcac gugcgacauc     2340

ggcgacuucc ggcgcuggau ggacgagcac cugaacguga agaucccccg gcuggucgac     2400

gugaucugcg cgagcccggg ggaccagcgc ggcaagucca ucgugagccu cgagcugacg     2460

accugcgucu ccgacgugac cgccgucauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc ucgccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgucugcc ucgcgaaggu gaagggguac cggagccugu ccaccagcca gaccuucuac     2640

gacgccuacg ugagcuacga caccaaggac gccuccguca ccgacugggu gaucaacgag     2700

cugcgcuacc accucgagga gagccgggac aagaacgugc ugcugugccu cgaggagcgc     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc aguccaucaa ccagagcaag     2820

aagaccgucu ucgugcugac gaagaaguac gcgaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc ugcagcggcu gauggacgag aacauggacg ugaucaucuu cauccuccug     2940

gagcccgucc ugcagcacag ccaguaccuc cgccugcggc agcgcaucug caaguccagc     3000

auccugcagu ggcccgacaa cccgaaggcc gagggccucu ucuggcagac ccugcgcaac     3060

guggugcuga ccgagaacga cucccgguac aacaacaugu acgucgacag caucaagcag     3120

uacuga                                                                3126


<210>  9784
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR8__Homo_sapiens__AAI01076

<400>  9784
auggagaaca uguuccucca guccuccaug cucaccugca ucuuccuccu caucuccggc       60

uccugcgagc ucugcgccga ggagaacuuc ucccgcuccu accccugcga cgagaagaag      120

cagaacgacu ccgucaucgc cgagugcucc aaccgccgcc uccaggaggu cccccagacc      180

gucggcaagu acgucaccga gcucgaccuc uccgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccucca gaaccucacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acggcaaccc cggcauccag uccaacggcc ucaacaucac cgacggcgcc      360

uuccucaacc ucaagaaccu ccgcgagcuc cuccucgagg acaaccagcu cccccagauc      420

cccuccggcc uccccgaguc ccucaccgag cucucccuca uccagaacaa caucuacaac      480

aucaccaagg agggcaucuc ccgccucauc aaccucaaga accucuaccu cgccuggaac      540

ugcuacuuca acaaggucug cgagaagacc aacaucgagg acggcgucuu cgagacccuc      600

accaaccucg agcuccucuc ccucuccuuc aacucccucu cccacguccc ccccaagcuc      660

cccuccuccc uccgcaagcu cuuccucucc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg gccucaucaa ccucacccuc cucgaccucu ccggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cguccccugc gacggcggcg ccuccaucaa caucgaccgc      840

uucgccuucc agaaccucac ccagcuccgc uaccucaacc ucuccuccac cucccuccgc      900

aagaucaacg ccgccugguu caagaacaug ccccaccuca agguccucga ccucgaguuc      960

aacuaccucg ucggcgagau cgccuccggc gccuuccuca ccaugcuccc ccgccucgag     1020

auccucgacc ucuccuucaa cuacaucaag ggcuccuacc cccagcacau caacaucucc     1080

cgcaacuucu ccaagcuccu cucccuccgc gcccuccacc uccgcggcua cgucuuccag     1140

gagcuccgcg aggacgacuu ccagccccuc augcagcucc ccaaccucuc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcucu uccagaacuu cuccaaccuc     1260

gagaucaucu accucuccga gaaccgcauc uccccccucg ucaaggacac ccgccagucc     1320

uacgccaacu ccuccuccuu ccagcgccac auccgcaagc gccgcuccac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccgccccc ucaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccucucccuc aacuccaucu ucuucaucgg ccccaaccag     1500

uucgagaacc uccccgacau cgccugccuc aaccucuccg ccaacuccaa cgcccagguc     1560

cucuccggca ccgaguucuc cgccaucccc cacgucaagu accucgaccu caccaacaac     1620

cgccucgacu ucgacaacgc cuccgcccuc accgagcucu ccgaccucga gguccucgac     1680

cucuccuaca acucccacua cuuccgcauc gccggcguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccucaa gguccucaac cucucccaca acaacaucua cacccucacc     1800

gacaaguaca accucgaguc caagucccuc gucgagcucg ucuucuccgg caaccgccuc     1860

gacauccucu ggaacgacga cgacaaccgc uacaucucca ucuucaaggg ccucaagaac     1920

cucacccgcc ucgaccucuc ccucaaccgc cucaagcaca uccccaacga ggccuuccuc     1980

aaccuccccg ccucccucac cgagcuccac aucaacgaca acaugcucaa guucuucaac     2040

uggacccucc uccagcaguu cccccgccuc gagcuccucg accuccgcgg caacaagcuc     2100

cucuuccuca ccgacucccu cuccgacuuc accuccuccc uccgcacccu ccuccucucc     2160

cacaaccgca ucucccaccu ccccuccggc uuccucuccg aggucuccuc ccucaagcac     2220

cucgaccucu ccuccaaccu ccucaagacc aucaacaagu ccgcccucga gaccaagacc     2280

accaccaagc ucuccaugcu cgagcuccac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuucc gccgcuggau ggacgagcac cucaacguca agaucccccg ccucgucgac     2400

gucaucugcg ccucccccgg cgaccagcgc ggcaagucca ucgucucccu cgagcucacc     2460

accugcgucu ccgacgucac cgccgucauc cucuucuucu ucaccuucuu caucaccacc     2520

auggucaugc ucgccgcccu cgcccaccac cucuucuacu gggacgucug guucaucuac     2580

aacgucugcc ucgccaaggu caagggcuac cgcucccucu ccaccuccca gaccuucuac     2640

gacgccuacg ucuccuacga caccaaggac gccuccguca ccgacugggu caucaacgag     2700

cuccgcuacc accucgagga gucccgcgac aagaacgucc uccucugccu cgaggagcgc     2760

gacugggacc ccggccucgc caucaucgac aaccucaugc aguccaucaa ccaguccaag     2820

aagaccgucu ucguccucac caagaaguac gccaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc uccagcgccu cauggacgag aacauggacg ucaucaucuu cauccuccuc     2940

gagcccgucc uccagcacuc ccaguaccuc cgccuccgcc agcgcaucug caaguccucc     3000

auccuccagu ggcccgacaa ccccaaggcc gagggccucu ucuggcagac ccuccgcaac     3060

gucguccuca ccgagaacga cucccgcuac aacaacaugu acgucgacuc caucaagcag     3120

uacuga                                                                3126


<210>  9785
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR8__Homo_sapiens__AAI01076

<400>  9785
auggagaaca uguuccugca gagcuccaug uugaccugca ucuuucuucu gauuucuggc       60

ucaugugaau ugugcgccga ggaaaauuuc aguagaagcu accccuguga cgagaagaaa      120

caaaacgauu ccgugauagc ugaaugcucu aauaggcggu uacaggaggu cccucagaca      180

guugggaagu augugacuga gcuggaccua ucggauaacu uuaucacgca cauuaccaau      240

gaaucauucc agggacucca aaaccugaca aaaaucaauc uuaaccauaa uccaaacgua      300

cagcaccaga augguaaccc gggcauucag agcaaugggc ugaacaucac ugacggagca      360

uuuuugaauc ucaagaaccu gcgcgagcug cucuuagaag auaaccaacu gccccagaua      420

ccuaguggcc uuccagaguc cuugaccgag cugucucuaa uccagaauaa cauuuacaau      480

aucacaaaag aagguauuag ccgacucauc aaccugaaga aucuuuaucu ggccuggaac      540

uguuacuuca auaaggugug cgagaaaacc aacauagaag acggggucuu ugagacuuug      600

acaaaucucg aacuguuauc ccugucauuc aacagucuca gccaugugcc cccuaaacuu      660

ccaucuuccc ugcguaaguu guuucuauca aauacccaga uuaaguauau cagcgaggag      720

gauuucaaag gacugauuaa ccucacgcug cuugaccuga guggcaauug ucccagaugc      780

uuuaacgcgc cuuucccaug uguuccgugc gauggcgggg cuucuaucaa uaucgacagg      840

uuugccuucc aaaacuugac ucagcuccgg uaccugaacu uauccagcac cucgcugcgc      900

aagauuaaug cagccugguu caagaacaug ccccaccuaa aagugcucga ucuggaauuu      960

aauuaucuug ucggagagau agcuucuggu gcauucuuga caaugcugcc uagacucgaa     1020

auccuggacc uuuccuuuaa cuacauuaag ggcucauacc cacagcauau caauauaagu     1080

aggaacuuca gcaaacuguu gucccuccgg gcccugcacu uacgcgggua uguguuucaa     1140

gagcugcgag aagaugacuu ccagccccua augcagcucc cuaaucuguc uacuauuaac     1200

cuuggaauca auuuuaucaa gcagauugac uucaaauugu uucaaaacuu cagcaaucug     1260

gagaucauuu accucucaga gaacagaaua aguccacugg uaaaggauac caggcagucc     1320

uaugcuaauu cuucuucauu ucagcggcac auccguaaac gcagaaguac agacuucgaa     1380

uuugaucccc auagcaacuu cuaccacuuc accaggccgu uaauuaagcc ucagugugcc     1440

gcguauggca aggcacugga ccuuuccuug aauagcaucu uuuucaucgg ucccaaccaa     1500

uuugagaacc ucccagauau ugccugccug aaucuaucgg cuaacagcaa ugcccagguu     1560

cuguccggga cggaauuuuc agcaauaccu caugugaaau accucgaccu gacuaacaau     1620

cggcuugauu uugacaacgc uagugccuug acagagcugu cugauuuaga aguccucgac     1680

cugagcuaua auucccacua cuuccgaauc gcgggaguga cccaccaucu ugaguuuauu     1740

cagaacuuca cuaaucugaa gguguugaac cucucacaca auaacaucua cacacugacc     1800

gauaaauaua aucuagagag caagucucug gucgaacucg uuuucuccgg caaccgccug     1860

gacauucuuu ggaaugacga ugacaacaga uacaucagua uauucaaagg cuugaagaac     1920

cugacgaggu uagaucucag ccugaaucgg cuuaagcaua uccccaacga ggccuuucug     1980

aaucuaccag caucucucac cgaacugcac auuaacgaca auauguugaa auucuuuaac     2040

uggacacugu uacagcaauu cccccgccuc gagcugcuug aucugagagg gaauaagcuc     2100

cucuuccuga cugacucccu aucagauuuu accaguagcc ugaggacacu ucuccugucg     2160

cauaaccgua ucucccacuu gccuucugga uuccugagcg aggugucaag uuuaaaacac     2220

cucgaccugu ccucuaaucu ucugaagacu auuaacaaaa gcgcuuugga aaccaagaca     2280

accacuaagc ucuccaugcu ggagcuacau gguaauccau uugaaugcac gugugauauc     2340

ggcgacuucc ggcgauggau ggaugagcac cugaacguaa aaauaccgag acuuguggac     2400

gucauuugcg ccucacccgg ggaucagagg ggaaagagca ucgugagucu cgaacugaca     2460

accuguguuu cugacgugac ugcugucauu uuguuuuucu uuaccuucuu uaucacaacc     2520

auggugaugu uagccgcacu ggcccaucac cucuucuauu gggacguaug guuuauauac     2580

aauguuugcc uggcuaaagu gaagggcuau cgcucccuua gcacuucgca gacauucuac     2640

gaugcguaug ucucauacga cacgaaagau gcaucuguga ccgacugggu caucaacgag     2700

cugcgguacc acuuggagga aaguagagau aagaaugugc uacugugucu cgaggaaagg     2760

gacugggauc cuggucuggc cauuaucgac aaccuuaugc aguccauuaa ucaaagcaag     2820

aaaacuguuu ucguguuaac aaagaaauau gcuaagucuu ggaacuuuaa aaccgccuuc     2880

uaccuggcac uccagcgcuu gauggaugag aacauggacg uaaucauauu uauucugcuc     2940

gaaccagucc ugcagcauag ccaauaucuu cgacugcggc agcguaucug caaguccuca     3000

aucuugcagu ggcccgauaa uccuaaagcc gaggggcuau ucuggcagac acugagaaac     3060

gugguucuca cugagaauga caguagguac aacaauaugu auguggauag cauuaagcaa     3120

uacuga                                                                3126


<210>  9786
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR8__Homo_sapiens__AAI01076

<400>  9786
auggagaaca uguuccugca gagcagcaug cugaccugca ucuuccugcu gaucagcggc       60

agcugcgagc ugugcgccga ggagaacuuc agcagaagcu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcagc aacagaagac ugcaggaggu gccccagacc      180

gugggcaagu acgugaccga gcuggaccug agcgacaacu ucaucaccca caucaccaac      240

gagagcuucc agggccugca gaaccugacc aagaucaacc ugaaccacaa ccccaacgug      300

cagcaccaga acggcaaccc cggcauccag agcaacggcc ugaacaucac cgacggcgcc      360

uuccugaacc ugaagaaccu gagagagcug cugcuggagg acaaccagcu gccccagauc      420

cccagcggcc ugcccgagag ccugaccgag cugagccuga uccagaacaa caucuacaac      480

aucaccaagg agggcaucag cagacugauc aaccugaaga accuguaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacccug      600

accaaccugg agcugcugag ccugagcuuc aacagccuga gccacgugcc ccccaagcug      660

cccagcagcc ugagaaagcu guuccugagc aacacccaga ucaaguacau cagcgaggag      720

gacuucaagg gccugaucaa ccugacccug cuggaccuga gcggcaacug ccccagaugc      780

uucaacgccc ccuuccccug cgugcccugc gacggcggcg ccagcaucaa caucgacaga      840

uucgccuucc agaaccugac ccagcugaga uaccugaacc ugagcagcac cagccugaga      900

aagaucaacg ccgccugguu caagaacaug ccccaccuga aggugcugga ccuggaguuc      960

aacuaccugg ugggcgagau cgccagcggc gccuuccuga ccaugcugcc cagacuggag     1020

auccuggacc ugagcuucaa cuacaucaag ggcagcuacc cccagcacau caacaucagc     1080

agaaacuuca gcaagcugcu gagccugaga gcccugcacc ugagaggcua cguguuccag     1140

gagcugagag aggacgacuu ccagccccug augcagcugc ccaaccugag caccaucaac     1200

cugggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accugagcga gaacagaauc agcccccugg ugaaggacac cagacagagc     1320

uacgccaaca gcagcagcuu ccagagacac aucagaaaga gaagaagcac cgacuucgag     1380

uucgaccccc acagcaacuu cuaccacuuc accagacccc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccugga ccugagccug aacagcaucu ucuucaucgg ccccaaccag     1500

uucgagaacc ugcccgacau cgccugccug aaccugagcg ccaacagcaa cgcccaggug     1560

cugagcggca ccgaguucag cgccaucccc cacgugaagu accuggaccu gaccaacaac     1620

agacuggacu ucgacaacgc cagcgcccug accgagcuga gcgaccugga ggugcuggac     1680

cugagcuaca acagccacua cuucagaauc gccggcguga cccaccaccu ggaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cugagccaca acaacaucua cacccugacc     1800

gacaaguaca accuggagag caagagccug guggagcugg uguucagcgg caacagacug     1860

gacauccugu ggaacgacga cgacaacaga uacaucagca ucuucaaggg ccugaagaac     1920

cugaccagac uggaccugag ccugaacaga cugaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccugac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacccugc ugcagcaguu ccccagacug gagcugcugg accugagagg caacaagcug     2100

cuguuccuga ccgacagccu gagcgacuuc accagcagcc ugagaacccu gcugcugagc     2160

cacaacagaa ucagccaccu gcccagcggc uuccugagcg aggugagcag ccugaagcac     2220

cuggaccuga gcagcaaccu gcugaagacc aucaacaaga gcgcccugga gaccaagacc     2280

accaccaagc ugagcaugcu ggagcugcac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuuca gaagauggau ggacgagcac cugaacguga agauccccag acugguggac     2400

gugaucugcg ccagccccgg cgaccagaga ggcaagagca ucgugagccu ggagcugacc     2460

accugcguga gcgacgugac cgccgugauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc uggccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgugugcc uggccaaggu gaagggcuac agaagccuga gcaccagcca gaccuucuac     2640

gacgccuacg ugagcuacga caccaaggac gccagcguga ccgacugggu gaucaacgag     2700

cugagauacc accuggagga gagcagagac aagaacgugc ugcugugccu ggaggagaga     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc agagcaucaa ccagagcaag     2820

aagaccgugu ucgugcugac caagaaguac gccaagagcu ggaacuucaa gaccgccuuc     2880

uaccuggccc ugcagagacu gauggacgag aacauggacg ugaucaucuu cauccugcug     2940

gagcccgugc ugcagcacag ccaguaccug agacugagac agagaaucug caagagcagc     3000

auccugcagu ggcccgacaa ccccaaggcc gagggccugu ucuggcagac ccugagaaac     3060

guggugcuga ccgagaacga cagcagauac aacaacaugu acguggacag caucaagcag     3120

uacuga                                                                3126


<210>  9787
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR8__Homo_sapiens__AAI01076

<400>  9787
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuucugcu uauuucuggc       60

agcugugaac ugugcgccga ggaaaauuuc uccagaucuu accccuguga cgagaagaaa      120

caaaacgaua gcgugaucgc ugaaugcucc aaucggcgcc uccaggaggu cccucagaca      180

guugggaagu augugacgga gcuggaccuu ucugauaacu uuauuaccca caucacaaau      240

gaauccuucc agggacugca aaaccucacc aaaauuaauc ugaaccauaa uccgaacgug      300

cagcaccaga auggcaaccc cgggauccag uccaauggac ugaacaucac agacggcgcc      360

uuucucaauc ugaagaaccu uagagagcug cuccuggaag auaaccaacu uccucagauu      420

cccagcgggc ugccugaguc ucucaccgag cugucccuga uccagaauaa cauuuacaau      480

aucacaaaag aaggaauuag ccggcucauc aaccugaaga aucuuuaucu ggcguggaac      540

uguuacuuca auaaggucug cgagaaaacc aacauugaag acggcguguu ugagacgcuc      600

accaaucugg aacuucuguc ucucuccuuc aacagccugu cucauguucc cccuaagcug      660

ccguccagcc uccgcaaacu guuucuuucc aauacacaga ucaaguauau cucugaggag      720

gauuucaaag gccugauuaa ccucacccug cuugaccuga gcgggaauug ucccagaugc      780

uuuaacgcuc cuuuccccug ugugccuugc gauggaggcg ccuccaucaa uauugaccgg      840

uuugccuucc aaaaccucac acagcugcgc uaccugaacc ucagcucuac cucccugaga      900

aagaucaaug cugccugguu caagaacaug ccccaccuua aaguccugga ucucgaauuu      960

aauuaucugg ugggggagau ugcuagcgga gccuuccuga cgaugcuucc gcggcucgaa     1020

auccuggacc ugucuuuuaa cuacaucaag ggcagcuacc cucagcauau uaauaucucc     1080

cgcaacuucu cuaaacuccu gagccuuaga gcgcugcacc uccgggggua uguuuuucaa     1140

gagcugcgcg aagaugacuu ccagccccug augcagcuuc cuaaucucuc cacaauuaac     1200

cugggaauca auuuuauuaa gcagaucgac uucaaacugu uucaaaacuu cagcaaucuc     1260

gagaucauuu accugucuga gaacagaauc agcccccuug ugaaggauac ccggcagagc     1320

uaugccaauu cuuccagcuu ucagcgccac auuagaaaac ggagauccac agacuucgaa     1380

uuugaucccc auucuaacuu cuaccacuuc acccgcccuc ugaucaagcc gcagugugcu     1440

gccuauggca aggcucucga ccugagccuc aauuccauuu ucuucaucgg ccccaaccaa     1500

uuugagaacc uuccugauau ugccugccuc aaucugucug cgaacagcaa ugcccagguc     1560

cuguccggga ccgaauuuag cgcuaucccc caugugaaau accucgaccu gacaaacaau     1620

cggcuugauu uugacaacgc cucugcucug acggagcucu ccgaucugga agugcuggac     1680

cuuagcuaua auucucacua cuucagaauc gccggaguca cccaccaucu cgaguuuauu     1740

cagaacuuca caaaucugaa gguucugaac cucucccaca auaacaucua cacccugaca     1800

gauaaauaua aucuugagag caagucucug guggaacucg uguuuagcgg caaccgccug     1860

gacauucugu ggaaugacga ugacaaccgg uacaucucca uuuucaaagg gcuuaagaac     1920

cugaccagac ucgaucugag ccucaaucgc cugaagcaua ucccuaacga ggccuuucuu     1980

aaucugcccg cuucucucac ggaacugcac aucaacgaca auaugcugaa auucuuuaac     2040

uggacacuuc ugcagcaauu cccgcggcuc gagcugcucg aucugagagg aaauaaacuu     2100

cuguuccuca ccgacucccu gagcgauuuu accuccucuc ugcgcacacu ucugcucagc     2160

cauaaccgga uuucccaucu gccuucuggc uuccucagcg aggucuccuc ucugaagcac     2220

cuugaccuga gcuccaaucu gcucaagacc aucaacaaaa gcgcgcugga aacaaagacg     2280

accacaaaac uuucuaugcu ggagcuccac gggaaucccu uugaaugcac cugugauauu     2340

ggagacuuca gacgcuggau ggaugagcac cugaacguga agaucccucg gcucguugac     2400

gugauuugcg ccucccccgg cgaucagaga ggcaagagca ucgucucucu ggaacuuaca     2460

accugugugu ccgacguuac ggcugugauc cuguuuuucu uuaccuucuu uauuacaacc     2520

auggucaugc uggccgcccu cgcucaucac cuguucuauu gggacgugug guuuaucuac     2580

aaugucugcc uugccaaagu gaagggguau cggagccugu cuacauccca gaccuucuac     2640

gaugcguaug uuagcuacga cacgaaagau gcuuccguga cagacugggu cauuaacgag     2700

cuccgcuacc accuggagga aagcagagau aagaaugugc uccugugucu ugaggaacgg     2760

gacugggauc cuggacuggc caucauugac aaccugaugc agucuaucaa ucaaagcaag     2820

aaaaccguuu ucgugcucac aaagaaauau gccaaguccu ggaacuuuaa aaccgcuuuc     2880

uaccuggccc uucagagacu gauggaugag aacauggacg ucaucauuuu uauccuccug     2940

gaacccgugc uccagcauuc ucaauaucug cgccuucggc agagaauuug caagagcucc     3000

auccugcagu ggccggauaa uccuaaagcu gagggccugu ucuggcagac ccuccgcaac     3060

gugguucuga cagagaauga cucuagauac aacaauaugu augucgauag cauuaagcaa     3120

uacuga                                                                3126


<210>  9788
<211>  1041
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__Q495P7

<400>  9788

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg 
            20                  25                  30          


Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu 
        35                  40                  45              


Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr 
    50                  55                  60                  


Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn 
65                  70                  75                  80  


Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His 
                85                  90                  95      


Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn 
            100                 105                 110         


Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg 
        115                 120                 125             


Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn 
145                 150                 155                 160 


Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr 
                165                 170                 175     


Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile 
            180                 185                 190         


Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu 
        195                 200                 205             


Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu 
    210                 215                 220                 


Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu 
225                 230                 235                 240 


Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn 
                245                 250                 255     


Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly 
            260                 265                 270         


Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln 
        275                 280                 285             


Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala 
    290                 295                 300                 


Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe 
305                 310                 315                 320 


Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu 
                325                 330                 335     


Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser 
            340                 345                 350         


Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser 
        355                 360                 365             


Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu 
    370                 375                 380                 


Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn 
385                 390                 395                 400 


Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn 
                405                 410                 415     


Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro 
            420                 425                 430         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        435                 440                 445             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    450                 455                 460                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala 
465                 470                 475                 480 


Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile 
                485                 490                 495     


Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu 
            500                 505                 510         


Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala 
        515                 520                 525             


Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe 
    530                 535                 540                 


Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp 
545                 550                 555                 560 


Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His 
                565                 570                 575     


Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser 
            580                 585                 590         


His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys 
        595                 600                 605             


Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp 
    610                 615                 620                 


Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn 
625                 630                 635                 640 


Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn 
                645                 650                 655     


Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn 
            660                 665                 670         


Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro 
        675                 680                 685             


Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr 
    690                 695                 700                 


Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser 
705                 710                 715                 720 


His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser 
                725                 730                 735     


Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn 
            740                 745                 750         


Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu 
        755                 760                 765             


Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg 
    770                 775                 780                 


Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp 
785                 790                 795                 800 


Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser 
                805                 810                 815     


Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe 
            820                 825                 830         


Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala 
        835                 840                 845             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    850                 855                 860                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
865                 870                 875                 880 


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                885                 890                 895     


Val Ile Asn Glu Leu Cys Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            900                 905                 910         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        915                 920                 925             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    930                 935                 940                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
945                 950                 955                 960 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                965                 970                 975     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            980                 985                 990         


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
        995                 1000                1005            


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
    1010                1015                1020                


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
1025                1030                1035                1040


Tyr 
    


<210>  9789
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__AAI01075

<400>  9789
auggaaaaca uguuccuuca gucgucaaug cugaccugca uuuuccugcu aauaucuggu       60

uccugugagu uaugcgccga agaaaauuuu ucuagaagcu auccuuguga ugagaaaaag      120

caaaaugacu caguuauugc agagugcagc aaucgucgac uacaggaagu uccccaaacg      180

gugggcaaau augugacaga acuagaccug ucugauaauu ucaucacaca cauaacgaau      240

gaaucauuuc aagggcugca aaaucucacu aaaauaaauc uaaaccacaa ccccaaugua      300

cagcaccaga acggaaaucc cgguauacaa ucaaauggcu ugaauaucac agacggggca      360

uuccucaacc uaaaaaaccu aagggaguua cugcuugaag acaaccaguu accccaaaua      420

cccucugguu ugccagaguc uuugacagaa cuuagucuaa uucaaaacaa uauauacaac      480

auaacuaaag agggcauuuc aagacuuaua aacuugaaaa aucucuauuu ggccuggaac      540

ugcuauuuua acaaaguuug cgagaaaacu aacauagaag auggaguauu ugaaacgcug      600

acaaauuugg aguugcuauc acuaucuuuc aauucucuuu cacaugugcc acccaaacug      660

ccaagcuccc uacgcaaacu uuuucugagc aacacccaga ucaaauacau uagugaagaa      720

gauuucaagg gauugauaaa uuuaacauua cuagauuuaa gcgggaacug uccgaggugc      780

uucaaugccc cauuuccaug cgugccuugu gaugguggug cuucaauuaa uauagaucgu      840

uuugcuuuuc aaaacuugac ccaacuucga uaccuaaacc ucucuagcac uucccucagg      900

aagauuaaug cugccugguu uaaaaauaug ccucaucuga aggugcugga ucuugaauuc      960

aacuauuuag ugggagaaau agccucuggg gcauuuuuaa cgaugcugcc ccgcuuagaa     1020

auacuugacu ugucuuuuaa cuauauaaag gggaguuauc cacagcauau uaauauuucc     1080

agaaacuucu cuaaacuuuu gucucuacgg gcauugcauu uaagagguua uguguuccag     1140

gaacucagag aagaugauuu ccagccccug augcagcuuc caaacuuauc gacuaucaac     1200

uuggguauua auuuuauuaa gcaaaucgau uucaaacuuu uccaaaauuu cuccaaucug     1260

gaaauuauuu acuugucaga aaacagaaua ucaccguugg uaaaagauac ccggcagagu     1320

uaugcaaaua guuccucuuu ucaacgucau auccggaaac gacgcucaac agauuuugag     1380

uuugacccac auucgaacuu uuaucauuuc acccguccuu uaauaaagcc acaaugugcu     1440

gcuuauggaa aagccuuaga uuuaagccuc aacaguauuu ucuucauugg gccaaaccaa     1500

uuugaaaauc uuccugacau ugccuguuua aaucugucug caaauagcaa ugcucaagug     1560

uuaaguggaa cugaauuuuc agccauuccu caugucaaau auuuggauuu gacaaacaau     1620

agacuagacu uugauaaugc uagugcucuu acugaauugu ccgacuugga aguucuagau     1680

cucagcuaua auucacacua uuucagaaua gcaggcguaa cacaucaucu agaauuuauu     1740

caaaauuuca caaaucuaaa aguuuuaaac uugagccaca acaacauuua uacuuuaaca     1800

gauaaguaua accuggaaag caagucccug guagaauuag uuuucagugg caaucgccuu     1860

gacauuuugu ggaaugauga ugacaacagg uauaucucca uuuucaaagg ucucaagaau     1920

cugacacguc uggauuuauc ccuuaauagg cucaagcaca ucccaaauga agcauuccuu     1980

aauuugccag cgagucucac ugaacuacau auaaaugaua auauguuaaa guuuuuuaac     2040

uggacauuac uccagcaguu uccucgucuc gaguugcuug acuuacgugg aaacaaacua     2100

cucuuuuuaa cugauagccu aucugacuuu acaucuuccc uucggacacu gcugcugagu     2160

cauaacagga uuucccaccu acccucuggc uuucuuucug aagucaguag ucugaagcac     2220

cucgauuuaa guuccaaucu gcuaaaaaca auaaacaaau ccgcacuuga aacuaagacc     2280

accaccaaau uaucuauguu ggaacuacac ggaaaccccu uugaaugcac cugugacauu     2340

ggagauuucc gaagauggau ggaugaacau cugaauguca aaauucccag acugguagau     2400

gucauuugug ccaguccugg ggaucaaaga gggaagagua uugugagucu ggagcuaaca     2460

acuuguguuu cagaugucac ugcagugaua uuauuuuucu ucacguucuu uaucaccacc     2520

augguuaugu uggcugcccu ggcucaccau uuguuuuacu gggauguuug guuuauauau     2580

aauguguguu uagcuaaggu aaaaggcuac aggucucuuu ccacauccca aacuuucuau     2640

gaugcuuaca uuucuuauga caccaaagau gccucuguua cugacugggu gauaaaugag     2700

cugugcuacc accuugaaga gagccgagac aaaaacguuc uccuuugucu agaggagagg     2760

gauugggacc cgggauuggc caucaucgac aaccucaugc agagcaucaa ccaaagcaag     2820

aaaacaguau uuguuuuaac caaaaaauau gcaaaaagcu ggaacuuuaa aacagcuuuu     2880

uacuuggcuu ugcagaggcu aauggaugag aacauggaug ugauuauauu uauccugcug     2940

gagccagugu uacagcauuc ucaguauuug aggcuacggc agcggaucug uaagagcucc     3000

auccuccagu ggccugacaa cccgaaggca gaaggcuugu uuuggcaaac ucugagaaau     3060

guggucuuga cugaaaauga uucacgguau aacaauaugu augucgauuc cauuaagcaa     3120

uacuaa                                                                3126


<210>  9790
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR8__Homo_sapiens__AAI01075

<400>  9790
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuccugcu gaucagcggc       60

uccugcgagc ucugcgccga ggagaacuuc agccgcuccu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcucc aaccggcgcc ugcaggaggu cccgcagacc      180

guggggaagu acgugacgga gcuggaccuc agcgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccugca gaaccugacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acgggaaccc cggcauccag agcaacgggc ugaacaucac ggacggcgcg      360

uuccugaacc ucaagaaccu gcgggagcug cuccuggagg acaaccagcu gccccagauc      420

ccguccggcc uccccgagag ccugaccgag cugucccuca uccagaacaa caucuacaac      480

aucaccaagg aggggaucag ccgccugauc aaccugaaga accucuaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacgcug      600

accaaccucg agcugcuguc ccucagcuuc aacucccuga gccacguccc gcccaagcug      660

cccuccagcc uccggaagcu guuccugagc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg ggcucaucaa ccugacccug cucgaccuga gcggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cgugccgugc gacgggggcg ccuccaucaa caucgaccgg      840

uucgccuucc agaaccugac gcagcuccgc uaccugaacc ugagcuccac cagccuccgg      900

aagaucaacg cggccugguu caagaacaug ccccaccuga aggugcugga ccucgaguuc      960

aacuaccugg ucggcgagau cgccuccggg gccuuccuga ccaugcugcc ccgccucgag     1020

auccuggacc ugagcuucaa cuacaucaag ggcuccuacc cccagcacau caacaucagc     1080

cggaacuucu ccaagcuccu gagccugcgc gcgcuccacc uccgggggua cguguuccag     1140

gagcugcgcg aggacgacuu ccagccgcuc augcagcugc ccaaccuguc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accucuccga gaaccggauc agcccccugg ugaaggacac gcgccagucc     1320

uacgccaaca gcuccagcuu ccagcggcac auccgcaagc ggcgcagcac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccggccgc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccugagccug aacuccaucu ucuucaucgg gcccaaccag     1500

uucgagaacc uccccgacau cgcgugccug aaccugagcg ccaacuccaa cgcccagguc     1560

cucagcggca ccgaguucuc cgccaucccg cacgugaagu accuggaccu gacgaacaac     1620

cgccucgacu ucgacaacgc cagcgcgcug accgagcugu ccgaccucga ggugcuggac     1680

cugagcuaca acucccacua cuuccgcauc gccgggguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cucagccaca acaacaucua cacgcugacc     1800

gacaaguaca accuggaguc caagagccuc guggagcugg ucuucuccgg caaccggcug     1860

gacauccucu ggaacgacga cgacaaccgc uacaucagca ucuucaaggg gcugaagaac     1920

cugacccggc ucgaccuguc ccugaaccgc cucaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccucac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacgcucc ugcagcaguu cccccggcug gagcuccugg accugcgcgg caacaagcuc     2100

cuguuccuga ccgacagccu cuccgacuuc accagcuccc ugcggacccu gcuccugagc     2160

cacaaccgca ucucccaccu cccgagcggc uuccuguccg aggugagcuc ccugaagcac     2220

cuggaccuca gcuccaaccu gcugaagacg aucaacaaga gcgcccucga gaccaagacc     2280

accacgaagc uguccaugcu ggagcuccac gggaaccccu ucgagugcac gugcgacauc     2340

ggcgacuucc ggcgcuggau ggacgagcac cugaacguga agaucccccg gcuggucgac     2400

gugaucugcg cgagcccggg ggaccagcgc ggcaagucca ucgugagccu cgagcugacg     2460

accugcgucu ccgacgugac cgccgucauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc ucgccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgucugcc ucgcgaaggu gaagggguac cggagccugu ccaccagcca gaccuucuac     2640

gacgccuaca ucagcuacga caccaaggac gccuccguga ccgacugggu caucaacgag     2700

cugugcuacc accucgagga gagccgcgac aagaacgugc ugcugugccu cgaggagcgg     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc aguccaucaa ccagagcaag     2820

aagaccgugu ucguccugac gaagaaguac gcgaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc ugcagcgccu gauggacgag aacauggacg ugaucaucuu cauccuccug     2940

gagcccgugc ugcagcacag ccaguaccuc cggcugcgcc agcggaucug caaguccagc     3000

auccugcagu ggcccgacaa cccgaaggcc gagggccucu ucuggcagac ccugcgcaac     3060

gucgugcuga ccgagaacga cucccgcuac aacaacaugu acguggacag caucaagcag     3120

uacuga                                                                3126


<210>  9791
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR8__Homo_sapiens__AAI01075

<400>  9791
auggagaaca uguuccucca guccuccaug cucaccugca ucuuccuccu caucuccggc       60

uccugcgagc ucugcgccga ggagaacuuc ucccgcuccu accccugcga cgagaagaag      120

cagaacgacu ccgucaucgc cgagugcucc aaccgccgcc uccaggaggu cccccagacc      180

gucggcaagu acgucaccga gcucgaccuc uccgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccucca gaaccucacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acggcaaccc cggcauccag uccaacggcc ucaacaucac cgacggcgcc      360

uuccucaacc ucaagaaccu ccgcgagcuc cuccucgagg acaaccagcu cccccagauc      420

cccuccggcc uccccgaguc ccucaccgag cucucccuca uccagaacaa caucuacaac      480

aucaccaagg agggcaucuc ccgccucauc aaccucaaga accucuaccu cgccuggaac      540

ugcuacuuca acaaggucug cgagaagacc aacaucgagg acggcgucuu cgagacccuc      600

accaaccucg agcuccucuc ccucuccuuc aacucccucu cccacguccc ccccaagcuc      660

cccuccuccc uccgcaagcu cuuccucucc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg gccucaucaa ccucacccuc cucgaccucu ccggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cguccccugc gacggcggcg ccuccaucaa caucgaccgc      840

uucgccuucc agaaccucac ccagcuccgc uaccucaacc ucuccuccac cucccuccgc      900

aagaucaacg ccgccugguu caagaacaug ccccaccuca agguccucga ccucgaguuc      960

aacuaccucg ucggcgagau cgccuccggc gccuuccuca ccaugcuccc ccgccucgag     1020

auccucgacc ucuccuucaa cuacaucaag ggcuccuacc cccagcacau caacaucucc     1080

cgcaacuucu ccaagcuccu cucccuccgc gcccuccacc uccgcggcua cgucuuccag     1140

gagcuccgcg aggacgacuu ccagccccuc augcagcucc ccaaccucuc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcucu uccagaacuu cuccaaccuc     1260

gagaucaucu accucuccga gaaccgcauc uccccccucg ucaaggacac ccgccagucc     1320

uacgccaacu ccuccuccuu ccagcgccac auccgcaagc gccgcuccac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccgccccc ucaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccucucccuc aacuccaucu ucuucaucgg ccccaaccag     1500

uucgagaacc uccccgacau cgccugccuc aaccucuccg ccaacuccaa cgcccagguc     1560

cucuccggca ccgaguucuc cgccaucccc cacgucaagu accucgaccu caccaacaac     1620

cgccucgacu ucgacaacgc cuccgcccuc accgagcucu ccgaccucga gguccucgac     1680

cucuccuaca acucccacua cuuccgcauc gccggcguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccucaa gguccucaac cucucccaca acaacaucua cacccucacc     1800

gacaaguaca accucgaguc caagucccuc gucgagcucg ucuucuccgg caaccgccuc     1860

gacauccucu ggaacgacga cgacaaccgc uacaucucca ucuucaaggg ccucaagaac     1920

cucacccgcc ucgaccucuc ccucaaccgc cucaagcaca uccccaacga ggccuuccuc     1980

aaccuccccg ccucccucac cgagcuccac aucaacgaca acaugcucaa guucuucaac     2040

uggacccucc uccagcaguu cccccgccuc gagcuccucg accuccgcgg caacaagcuc     2100

cucuuccuca ccgacucccu cuccgacuuc accuccuccc uccgcacccu ccuccucucc     2160

cacaaccgca ucucccaccu ccccuccggc uuccucuccg aggucuccuc ccucaagcac     2220

cucgaccucu ccuccaaccu ccucaagacc aucaacaagu ccgcccucga gaccaagacc     2280

accaccaagc ucuccaugcu cgagcuccac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuucc gccgcuggau ggacgagcac cucaacguca agaucccccg ccucgucgac     2400

gucaucugcg ccucccccgg cgaccagcgc ggcaagucca ucgucucccu cgagcucacc     2460

accugcgucu ccgacgucac cgccgucauc cucuucuucu ucaccuucuu caucaccacc     2520

auggucaugc ucgccgcccu cgcccaccac cucuucuacu gggacgucug guucaucuac     2580

aacgucugcc ucgccaaggu caagggcuac cgcucccucu ccaccuccca gaccuucuac     2640

gacgccuaca ucuccuacga caccaaggac gccuccguca ccgacugggu caucaacgag     2700

cucugcuacc accucgagga gucccgcgac aagaacgucc uccucugccu cgaggagcgc     2760

gacugggacc ccggccucgc caucaucgac aaccucaugc aguccaucaa ccaguccaag     2820

aagaccgucu ucguccucac caagaaguac gccaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc uccagcgccu cauggacgag aacauggacg ucaucaucuu cauccuccuc     2940

gagcccgucc uccagcacuc ccaguaccuc cgccuccgcc agcgcaucug caaguccucc     3000

auccuccagu ggcccgacaa ccccaaggcc gagggccucu ucuggcagac ccuccgcaac     3060

gucguccuca ccgagaacga cucccgcuac aacaacaugu acgucgacuc caucaagcag     3120

uacuga                                                                3126


<210>  9792
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR8__Homo_sapiens__AAI01075

<400>  9792
auggagaaca uguuccugca gagcuccaug uugaccugca ucuuucuucu gauuucuggc       60

ucaugugaau ugugcgccga ggaaaauuuc aguagaagcu accccuguga cgagaagaaa      120

caaaacgauu ccgugauagc ugaaugcucu aauaggcggu uacaggaggu cccucagaca      180

guugggaagu augugacuga gcuggaccua ucggauaacu uuaucacgca cauuaccaau      240

gaaucauucc agggacucca aaaccugaca aaaaucaauc uuaaccauaa uccaaacgua      300

cagcaccaga augguaaccc gggcauucag agcaaugggc ugaacaucac ugacggagca      360

uuuuugaauc ucaagaaccu gcgcgagcug cucuuagaag auaaccaacu gccccagaua      420

ccuaguggcc uuccagaguc cuugaccgag cugucucuaa uccagaauaa cauuuacaau      480

aucacaaaag aagguauuag ccgacucauc aaccugaaga aucuuuaucu ggccuggaac      540

uguuacuuca auaaggugug cgagaaaacc aacauagaag acggggucuu ugagacuuug      600

acaaaucucg aacuguuauc ccugucauuc aacagucuca gccaugugcc cccuaaacuu      660

ccaucuuccc ugcguaaguu guuucuauca aauacccaga uuaaguauau cagcgaggag      720

gauuucaaag gacugauuaa ccucacgcug cuugaccuga guggcaauug ucccagaugc      780

uuuaacgcgc cuuucccaug uguuccgugc gauggcgggg cuucuaucaa uaucgacagg      840

uuugccuucc aaaacuugac ucagcuccgg uaccugaacu uauccagcac cucgcugcgc      900

aagauuaaug cagccugguu caagaacaug ccccaccuaa aagugcucga ucuggaauuu      960

aauuaucuug ucggagagau agcuucuggu gcauucuuga caaugcugcc uagacucgaa     1020

auccuggacc uuuccuuuaa cuacauuaag ggcucauacc cacagcauau caauauaagu     1080

aggaacuuca gcaaacuguu gucccuccgg gcccugcacu uacgcgggua uguguuucaa     1140

gagcugcgag aagaugacuu ccagccccua augcagcucc cuaaucuguc uacuauuaac     1200

cuuggaauca auuuuaucaa gcagauugac uucaaauugu uucaaaacuu cagcaaucug     1260

gagaucauuu accucucaga gaacagaaua aguccacugg uaaaggauac caggcagucc     1320

uaugcuaauu cuucuucauu ucagcggcac auccguaaac gcagaaguac agacuucgaa     1380

uuugaucccc auagcaacuu cuaccacuuc accaggccgu uaauuaagcc ucagugugcc     1440

gcguauggca aggcacugga ccuuuccuug aauagcaucu uuuucaucgg ucccaaccaa     1500

uuugagaacc ucccagauau ugccugccug aaucuaucgg cuaacagcaa ugcccagguu     1560

cuguccggga cggaauuuuc agcaauaccu caugugaaau accucgaccu gacuaacaau     1620

cggcuugauu uugacaacgc uagugccuug acagagcugu cugauuuaga aguccucgac     1680

cugagcuaua auucccacua cuuccgaauc gcgggaguga cccaccaucu ugaguuuauu     1740

cagaacuuca cuaaucugaa gguguugaac cucucacaca auaacaucua cacacugacc     1800

gauaaauaua aucuagagag caagucucug gucgaacucg uuuucuccgg caaccgccug     1860

gacauucuuu ggaaugacga ugacaacaga uacaucagua uauucaaagg cuugaagaac     1920

cugacgaggu uagaucucag ccugaaucgg cuuaagcaua uccccaacga ggccuuucug     1980

aaucuaccag caucucucac cgaacugcac auuaacgaca auauguugaa auucuuuaac     2040

uggacacugu uacagcaauu cccccgccuc gagcugcuug aucugagagg gaauaagcuc     2100

cucuuccuga cugacucccu aucagauuuu accaguagcc ugaggacacu ucuccugucg     2160

cauaaccgua ucucccacuu gccuucugga uuccugagcg aggugucaag uuuaaaacac     2220

cucgaccugu ccucuaaucu ucugaagacu auuaacaaaa gcgcuuugga aaccaagaca     2280

accacuaagc ucuccaugcu ggagcuacau gguaauccau uugaaugcac gugugauauc     2340

ggcgacuucc ggcgauggau ggaugagcac cugaacguaa aaauaccgag acuuguggac     2400

gucauuugcg ccucacccgg ggaucagagg ggaaagagca ucgugagucu cgaacugaca     2460

accuguguuu cugacgugac ugcugucauu uuguuuuucu uuaccuucuu uaucacaacc     2520

auggugaugu uagccgcacu ggcccaucac cucuucuauu gggacguaug guuuauauac     2580

aauguuugcc uggcuaaagu gaagggcuau cgcucccuua gcacuucgca gacauucuac     2640

gaugcguaua ucucauacga cacgaaagau gcaucuguca ccgacugggu gauuaacgag     2700

cuguguuacc acuuggagga aagucgggau aagaaugucc uacugugccu cgaggaaaga     2760

gacugggauc cuggucuggc caucauugac aaccuuaugc aguccaucaa ucaaagcaag     2820

aaaacugugu ucguuuuaac aaagaaauau gcuaagucuu ggaacuuuaa aaccgccuuc     2880

uaccuggcac uccagagguu gauggaugag aacauggacg ugauaauuuu uauccugcuc     2940

gaaccaguac ugcagcauag ccaauaucuu cgccugcgac agcggaucug uaaguccuca     3000

auuuugcagu ggcccgauaa uccuaaagcc gaggggcuau ucuggcagac acugcguaac     3060

gucgugcuca cugagaauga caguagauac aacaauaugu auguugauag caucaagcaa     3120

uacuga                                                                3126


<210>  9793
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR8__Homo_sapiens__AAI01075

<400>  9793
auggagaaca uguuccugca gagcagcaug cugaccugca ucuuccugcu gaucagcggc       60

agcugcgagc ugugcgccga ggagaacuuc agcagaagcu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcagc aacagaagac ugcaggaggu gccccagacc      180

gugggcaagu acgugaccga gcuggaccug agcgacaacu ucaucaccca caucaccaac      240

gagagcuucc agggccugca gaaccugacc aagaucaacc ugaaccacaa ccccaacgug      300

cagcaccaga acggcaaccc cggcauccag agcaacggcc ugaacaucac cgacggcgcc      360

uuccugaacc ugaagaaccu gagagagcug cugcuggagg acaaccagcu gccccagauc      420

cccagcggcc ugcccgagag ccugaccgag cugagccuga uccagaacaa caucuacaac      480

aucaccaagg agggcaucag cagacugauc aaccugaaga accuguaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacccug      600

accaaccugg agcugcugag ccugagcuuc aacagccuga gccacgugcc ccccaagcug      660

cccagcagcc ugagaaagcu guuccugagc aacacccaga ucaaguacau cagcgaggag      720

gacuucaagg gccugaucaa ccugacccug cuggaccuga gcggcaacug ccccagaugc      780

uucaacgccc ccuuccccug cgugcccugc gacggcggcg ccagcaucaa caucgacaga      840

uucgccuucc agaaccugac ccagcugaga uaccugaacc ugagcagcac cagccugaga      900

aagaucaacg ccgccugguu caagaacaug ccccaccuga aggugcugga ccuggaguuc      960

aacuaccugg ugggcgagau cgccagcggc gccuuccuga ccaugcugcc cagacuggag     1020

auccuggacc ugagcuucaa cuacaucaag ggcagcuacc cccagcacau caacaucagc     1080

agaaacuuca gcaagcugcu gagccugaga gcccugcacc ugagaggcua cguguuccag     1140

gagcugagag aggacgacuu ccagccccug augcagcugc ccaaccugag caccaucaac     1200

cugggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accugagcga gaacagaauc agcccccugg ugaaggacac cagacagagc     1320

uacgccaaca gcagcagcuu ccagagacac aucagaaaga gaagaagcac cgacuucgag     1380

uucgaccccc acagcaacuu cuaccacuuc accagacccc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccugga ccugagccug aacagcaucu ucuucaucgg ccccaaccag     1500

uucgagaacc ugcccgacau cgccugccug aaccugagcg ccaacagcaa cgcccaggug     1560

cugagcggca ccgaguucag cgccaucccc cacgugaagu accuggaccu gaccaacaac     1620

agacuggacu ucgacaacgc cagcgcccug accgagcuga gcgaccugga ggugcuggac     1680

cugagcuaca acagccacua cuucagaauc gccggcguga cccaccaccu ggaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cugagccaca acaacaucua cacccugacc     1800

gacaaguaca accuggagag caagagccug guggagcugg uguucagcgg caacagacug     1860

gacauccugu ggaacgacga cgacaacaga uacaucagca ucuucaaggg ccugaagaac     1920

cugaccagac uggaccugag ccugaacaga cugaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccugac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacccugc ugcagcaguu ccccagacug gagcugcugg accugagagg caacaagcug     2100

cuguuccuga ccgacagccu gagcgacuuc accagcagcc ugagaacccu gcugcugagc     2160

cacaacagaa ucagccaccu gcccagcggc uuccugagcg aggugagcag ccugaagcac     2220

cuggaccuga gcagcaaccu gcugaagacc aucaacaaga gcgcccugga gaccaagacc     2280

accaccaagc ugagcaugcu ggagcugcac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuuca gaagauggau ggacgagcac cugaacguga agauccccag acugguggac     2400

gugaucugcg ccagccccgg cgaccagaga ggcaagagca ucgugagccu ggagcugacc     2460

accugcguga gcgacgugac cgccgugauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc uggccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgugugcc uggccaaggu gaagggcuac agaagccuga gcaccagcca gaccuucuac     2640

gacgccuaca ucagcuacga caccaaggac gccagcguga ccgacugggu gaucaacgag     2700

cugugcuacc accuggagga gagcagagac aagaacgugc ugcugugccu ggaggagaga     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc agagcaucaa ccagagcaag     2820

aagaccgugu ucgugcugac caagaaguac gccaagagcu ggaacuucaa gaccgccuuc     2880

uaccuggccc ugcagagacu gauggacgag aacauggacg ugaucaucuu cauccugcug     2940

gagcccgugc ugcagcacag ccaguaccug agacugagac agagaaucug caagagcagc     3000

auccugcagu ggcccgacaa ccccaaggcc gagggccugu ucuggcagac ccugagaaac     3060

guggugcuga ccgagaacga cagcagauac aacaacaugu acguggacag caucaagcag     3120

uacuga                                                                3126


<210>  9794
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR8__Homo_sapiens__AAI01075

<400>  9794
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuucugcu uauuucuggc       60

agcugugaac ugugcgccga ggaaaauuuc uccagaucuu accccuguga cgagaagaaa      120

caaaacgaua gcgugaucgc ugaaugcucc aaucggcgcc uccaggaggu cccucagaca      180

guugggaagu augugacgga gcuggaccuu ucugauaacu uuauuaccca caucacaaau      240

gaauccuucc agggacugca aaaccucacc aaaauuaauc ugaaccauaa uccgaacgug      300

cagcaccaga auggcaaccc cgggauccag uccaauggac ugaacaucac agacggcgcc      360

uuucucaauc ugaagaaccu uagagagcug cuccuggaag auaaccaacu uccucagauu      420

cccagcgggc ugccugaguc ucucaccgag cugucccuga uccagaauaa cauuuacaau      480

aucacaaaag aaggaauuag ccggcucauc aaccugaaga aucuuuaucu ggcguggaac      540

uguuacuuca auaaggucug cgagaaaacc aacauugaag acggcguguu ugagacgcuc      600

accaaucugg aacuucuguc ucucuccuuc aacagccugu cucauguucc cccuaagcug      660

ccguccagcc uccgcaaacu guuucuuucc aauacacaga ucaaguauau cucugaggag      720

gauuucaaag gccugauuaa ccucacccug cuugaccuga gcgggaauug ucccagaugc      780

uuuaacgcuc cuuuccccug ugugccuugc gauggaggcg ccuccaucaa uauugaccgg      840

uuugccuucc aaaaccucac acagcugcgc uaccugaacc ucagcucuac cucccugaga      900

aagaucaaug cugccugguu caagaacaug ccccaccuua aaguccugga ucucgaauuu      960

aauuaucugg ugggggagau ugcuagcgga gccuuccuga cgaugcuucc gcggcucgaa     1020

auccuggacc ugucuuuuaa cuacaucaag ggcagcuacc cucagcauau uaauaucucc     1080

cgcaacuucu cuaaacuccu gagccuuaga gcgcugcacc uccgggggua uguuuuucaa     1140

gagcugcgcg aagaugacuu ccagccccug augcagcuuc cuaaucucuc cacaauuaac     1200

cugggaauca auuuuauuaa gcagaucgac uucaaacugu uucaaaacuu cagcaaucuc     1260

gagaucauuu accugucuga gaacagaauc agcccccuug ugaaggauac ccggcagagc     1320

uaugccaauu cuuccagcuu ucagcgccac auuagaaaac ggagauccac agacuucgaa     1380

uuugaucccc auucuaacuu cuaccacuuc acccgcccuc ugaucaagcc gcagugugcu     1440

gccuauggca aggcucucga ccugagccuc aauuccauuu ucuucaucgg ccccaaccaa     1500

uuugagaacc uuccugauau ugccugccuc aaucugucug cgaacagcaa ugcccagguc     1560

cuguccggga ccgaauuuag cgcuaucccc caugugaaau accucgaccu gacaaacaau     1620

cggcuugauu uugacaacgc cucugcucug acggagcucu ccgaucugga agugcuggac     1680

cuuagcuaua auucucacua cuucagaauc gccggaguca cccaccaucu cgaguuuauu     1740

cagaacuuca caaaucugaa gguucugaac cucucccaca auaacaucua cacccugaca     1800

gauaaauaua aucuugagag caagucucug guggaacucg uguuuagcgg caaccgccug     1860

gacauucugu ggaaugacga ugacaaccgg uacaucucca uuuucaaagg gcuuaagaac     1920

cugaccagac ucgaucugag ccucaaucgc cugaagcaua ucccuaacga ggccuuucuu     1980

aaucugcccg cuucucucac ggaacugcac aucaacgaca auaugcugaa auucuuuaac     2040

uggacacuuc ugcagcaauu cccgcggcuc gagcugcucg aucugagagg aaauaaacuu     2100

cuguuccuca ccgacucccu gagcgauuuu accuccucuc ugcgcacacu ucugcucagc     2160

cauaaccgga uuucccaucu gccuucuggc uuccucagcg aggucuccuc ucugaagcac     2220

cuugaccuga gcuccaaucu gcucaagacc aucaacaaaa gcgcgcugga aacaaagacg     2280

accacaaaac uuucuaugcu ggagcuccac gggaaucccu uugaaugcac cugugauauu     2340

ggagacuuca gacgcuggau ggaugagcac cugaacguga agaucccucg gcucguugac     2400

gugauuugcg ccucccccgg cgaucagaga ggcaagagca ucgucucucu ggaacuuaca     2460

accugugugu ccgacguuac ggcugugauc cuguuuuucu uuaccuucuu uauuacaacc     2520

auggucaugc uggccgcccu cgcucaucac cuguucuauu gggacgugug guuuaucuac     2580

aaugucugcc uugccaaagu gaagggguau cggagccugu cuacauccca gaccuucuac     2640

gaugcguaua uuagcuacga cacgaaagau gcuuccguua cagacugggu gaucaacgag     2700

cucuguuacc accuggagga aagccgcgau aagaaugucc uccugugccu ugaggaaaga     2760

gacugggauc cuggacuggc cauuaucgac aaccugaugc agucuaucaa ucaaagcaag     2820

aaaaccgugu ucguucucac aaagaaauau gccaaguccu ggaacuuuaa aaccgcuuuc     2880

uaccuggccc uucagcggcu gauggaugag aacauggacg ugauuaucuu uauucuccug     2940

gaacccgucc uccagcauuc ucaauaucug agacuucgcc agcggaucug uaagagcucc     3000

auucugcagu ggccggauaa uccuaaagcu gagggccugu ucuggcagac ccucagaaac     3060

guggugcuga cagagaauga cucucgcuac aacaauaugu auguugauag caucaagcaa     3120

uacuga                                                                3126


<210>  9795
<211>  1041
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__Q9NR97

<400>  9795

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg 
            20                  25                  30          


Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu 
        35                  40                  45              


Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr 
    50                  55                  60                  


Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn 
65                  70                  75                  80  


Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His 
                85                  90                  95      


Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn 
            100                 105                 110         


Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg 
        115                 120                 125             


Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn 
145                 150                 155                 160 


Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr 
                165                 170                 175     


Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile 
            180                 185                 190         


Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu 
        195                 200                 205             


Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu 
    210                 215                 220                 


Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu 
225                 230                 235                 240 


Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn 
                245                 250                 255     


Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly 
            260                 265                 270         


Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln 
        275                 280                 285             


Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala 
    290                 295                 300                 


Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe 
305                 310                 315                 320 


Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu 
                325                 330                 335     


Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser 
            340                 345                 350         


Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser 
        355                 360                 365             


Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu 
    370                 375                 380                 


Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn 
385                 390                 395                 400 


Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn 
                405                 410                 415     


Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro 
            420                 425                 430         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        435                 440                 445             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    450                 455                 460                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala 
465                 470                 475                 480 


Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile 
                485                 490                 495     


Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu 
            500                 505                 510         


Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala 
        515                 520                 525             


Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe 
    530                 535                 540                 


Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp 
545                 550                 555                 560 


Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His 
                565                 570                 575     


Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser 
            580                 585                 590         


His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys 
        595                 600                 605             


Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp 
    610                 615                 620                 


Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn 
625                 630                 635                 640 


Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn 
                645                 650                 655     


Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn 
            660                 665                 670         


Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro 
        675                 680                 685             


Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr 
    690                 695                 700                 


Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser 
705                 710                 715                 720 


His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser 
                725                 730                 735     


Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn 
            740                 745                 750         


Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu 
        755                 760                 765             


Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg 
    770                 775                 780                 


Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp 
785                 790                 795                 800 


Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser 
                805                 810                 815     


Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe 
            820                 825                 830         


Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala 
        835                 840                 845             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    850                 855                 860                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
865                 870                 875                 880 


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                885                 890                 895     


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            900                 905                 910         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        915                 920                 925             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    930                 935                 940                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
945                 950                 955                 960 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                965                 970                 975     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            980                 985                 990         


Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro 
        995                 1000                1005            


Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr 
    1010                1015                1020                


Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln 
1025                1030                1035                1040


Tyr 
    


<210>  9796
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR8__Homo_sapiens__AAF78036

<400>  9796
auggaaaaca uguuccuuca gucgucaaug cugaccugca uuuuccugcu aauaucuggu       60

uccugugagu uaugcgccga agaaaauuuu ucuagaagcu auccuuguga ugagaaaaag      120

caaaaugacu caguuauugc agagugcagc aaucgucgac uacaggaagu uccccaaacg      180

gugggcaaau augugacaga acuagaccug ucugauaauu ucaucacaca cauaacgaau      240

gaaucauuuc aagggcugca aaaucucacu aaaauaaauc uaaaccacaa ccccaaugua      300

cagcaccaga acggaaaucc cgguauacaa ucaaauggcu ugaauaucac agacggggca      360

uuccucaacc uaaaaaaccu aagggaguua cugcuugaag acaaccaguu accccaaaua      420

cccucugguu ugccagaguc uuugacagaa cuuagucuaa uucaaaacaa uauauacaac      480

auaacuaaag agggcauuuc aagacuuaua aacuugaaaa aucucuauuu ggccuggaac      540

ugcuauuuua acaaaguuug cgagaaaacu aacauagaag auggaguauu ugaaacgcug      600

acaaauuugg aguugcuauc acuaucuuuc aauucucuuu cacacgugcc acccaaacug      660

ccaagcuccc uacgcaaacu uuuucugagc aacacccaga ucaaauacau uagugaagaa      720

gauuucaagg gauugauaaa uuuaacauua cuagauuuaa gcgggaacug uccgaggugc      780

uucaaugccc cauuuccaug cgugccuugu gaugguggug cuucaauuaa uauagaucgu      840

uuugcuuuuc aaaacuugac ccaacuucga uaccuaaacc ucucuagcac uucccucagg      900

aagauuaaug cugccugguu uaaaaauaug ccucaucuga aggugcugga ucuugaauuc      960

aacuauuuag ugggagaaau agccucuggg gcauuuuuaa cgaugcugcc ccgcuuagaa     1020

auacuugacu ugucuuuuaa cuauauaaag gggaguuauc cacagcauau uaauauuucc     1080

agaaacuucu cuaaacuuuu gucucuacgg gcauugcauu uaagagguua uguguuccag     1140

gaacucagag aagaugauuu ccagccccug augcagcuuc caaacuuauc gacuaucaac     1200

uuggguauua auuuuauuaa gcaaaucgau uucaaacuuu uccaaaauuu cuccaaucug     1260

gaaauuauuu acuugucaga aaacagaaua ucaccguugg uaaaagauac ccggcagagu     1320

uaugcaaaua guuccucuuu ucaacgucau auccggaaac gacgcucaac agauuuugag     1380

uuugacccac auucgaacuu uuaucauuuc acccguccuu uaauaaagcc acaaugugcu     1440

gcuuauggaa aagccuuaga uuuaagccuc aacaguauuu ucuucauugg gccaaaccaa     1500

uuugaaaauc uuccugacau ugccuguuua aaucugucug caaauagcaa ugcucaagug     1560

uuaaguggaa cugaauuuuc agccauuccu caugucaaau auuuggauuu gacaaacaau     1620

agacuagacu uugauaaugc uagugcucuu acugaauugu ccgacuugga aguucuagau     1680

cucagcuaua auucacacua uuucagaaua gcaggcguaa cacaucaucu agaauuuauu     1740

caaaauuuca caaaucuaaa aguuuuaaac uugagccaca acaacauuua uacuuuaaca     1800

gauaaguaua accuggaaag caagucccug guagaauuag uuuucagugg caaucgccuu     1860

gacauuuugu ggaaugauga ugacaacagg uauaucucca uuuucaaagg ucucaagaau     1920

cugacacguc uggauuuauc ccuuaauagg cugaagcaca ucccaaauga agcauuccuu     1980

aauuugccag cgagucucac ugaacuacau auaaaugaua auauguuaaa guuuuuuaac     2040

uggacauuac uccagcaguu cccucgucuc gaguugcuug acuuacgugg aaacaaacua     2100

cucuuuuuaa cugauagccu aucugacuuu acaucuuccc uucggacacu gcugcugagu     2160

cauaacagga uuucccaccu acccucuggc uuucuuucug aagucaguag ucugaagcac     2220

cucgauuuaa guuccaaucu gcuaaaaaca aucaacaaau ccgcacuuga aacuaagacc     2280

accaccaaau uaucuauguu ggaacuacac ggaaaccccu uugaaugcac cugugacauu     2340

ggagauuucc gaagauggau ggaugaacau cugaauguca aaauucccag acugguagau     2400

gucauuugug ccaguccugg ggaucaaaga gggaagagua uugugagucu ggagcugaca     2460

acuuguguuu cagaugucac ugcagugaua uuauuuuucu ucacguucuu uaucaccacc     2520

augguuaugu uggcugcccu ggcucaccau uuguuuuacu gggauguuug guuuauauau     2580

aauguguguu uagcuaaggu aaaaggcuac aggucucuuu ccacauccca aacuuucuau     2640

gaugcuuaca uuucuuauga caccaaagau gccucuguua cugacugggu gauaaaugag     2700

cugcgcuacc accuugaaga gagccgagac aaaaacguuc uccuuugucu agaggagagg     2760

gauugggacc cgggauuggc caucaucgac aaccucaugc agagcaucaa ccaaagcaag     2820

aaaacaguau uuguuuuaac caaaaaauau gcaaaaagcu ggaacuuuaa aacagcuuuu     2880

uacuuggcuu ugcagaggcu aauggaugag aacauggaug ugauuauauu uauccugcug     2940

gagccagugu uacagcauuc ucaguauuug aggcuacggc agcggaucug uaagagcucc     3000

auccuccagu ggccugacaa cccgaaggca gaaggcuugu uuuggcaaac ucugagaaau     3060

guggucuuga cugaaaauga uucacgguau aacaauaugu augucgauuc cauuaagcaa     3120

uacuaa                                                                3126


<210>  9797
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR8__Homo_sapiens__AAF78036

<400>  9797
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuccugcu gaucagcggc       60

uccugcgagc ucugcgccga ggagaacuuc agccgcuccu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcucc aaccggcgcc ugcaggaggu cccgcagacc      180

guggggaagu acgugacgga gcuggaccuc agcgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccugca gaaccugacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acgggaaccc cggcauccag agcaacgggc ugaacaucac ggacggcgcg      360

uuccugaacc ucaagaaccu gcgggagcug cuccuggagg acaaccagcu gccccagauc      420

ccguccggcc uccccgagag ccugaccgag cugucccuca uccagaacaa caucuacaac      480

aucaccaagg aggggaucag ccgccugauc aaccugaaga accucuaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacgcug      600

accaaccucg agcugcuguc ccucagcuuc aacucccuga gccacguccc gcccaagcug      660

cccuccagcc uccggaagcu guuccugagc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg ggcucaucaa ccugacccug cucgaccuga gcggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cgugccgugc gacgggggcg ccuccaucaa caucgaccgg      840

uucgccuucc agaaccugac gcagcuccgc uaccugaacc ugagcuccac cagccuccgg      900

aagaucaacg cggccugguu caagaacaug ccccaccuga aggugcugga ccucgaguuc      960

aacuaccugg ucggcgagau cgccuccggg gccuuccuga ccaugcugcc ccgccucgag     1020

auccuggacc ugagcuucaa cuacaucaag ggcuccuacc cccagcacau caacaucagc     1080

cggaacuucu ccaagcuccu gagccugcgc gcgcuccacc uccgggggua cguguuccag     1140

gagcugcgcg aggacgacuu ccagccgcuc augcagcugc ccaaccuguc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accucuccga gaaccggauc agcccccugg ugaaggacac gcgccagucc     1320

uacgccaaca gcuccagcuu ccagcggcac auccgcaagc ggcgcagcac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccggccgc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccugagccug aacuccaucu ucuucaucgg gcccaaccag     1500

uucgagaacc uccccgacau cgcgugccug aaccugagcg ccaacuccaa cgcccagguc     1560

cucagcggca ccgaguucuc cgccaucccg cacgugaagu accuggaccu gacgaacaac     1620

cgccucgacu ucgacaacgc cagcgcgcug accgagcugu ccgaccucga ggugcuggac     1680

cugagcuaca acucccacua cuuccgcauc gccgggguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cucagccaca acaacaucua cacgcugacc     1800

gacaaguaca accuggaguc caagagccuc guggagcugg ucuucuccgg caaccggcug     1860

gacauccucu ggaacgacga cgacaaccgc uacaucagca ucuucaaggg gcugaagaac     1920

cugacccggc ucgaccuguc ccugaaccgc cucaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccucac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacgcucc ugcagcaguu cccccggcug gagcuccugg accugcgcgg caacaagcuc     2100

cuguuccuga ccgacagccu cuccgacuuc accagcuccc ugcggacccu gcuccugagc     2160

cacaaccgca ucucccaccu cccgagcggc uuccuguccg aggugagcuc ccugaagcac     2220

cuggaccuca gcuccaaccu gcugaagacg aucaacaaga gcgcccucga gaccaagacc     2280

accacgaagc uguccaugcu ggagcuccac gggaaccccu ucgagugcac gugcgacauc     2340

ggcgacuucc ggcgcuggau ggacgagcac cugaacguga agaucccccg gcuggucgac     2400

gugaucugcg cgagcccggg ggaccagcgc ggcaagucca ucgugagccu cgagcugacg     2460

accugcgucu ccgacgugac cgccgucauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc ucgccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgucugcc ucgcgaaggu gaagggguac cggagccugu ccaccagcca gaccuucuac     2640

gacgccuaca ucagcuacga caccaaggac gccuccguga ccgacugggu caucaacgag     2700

cugcgcuacc accucgagga gagccgggac aagaacgugc ugcugugccu cgaggagcgc     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc aguccaucaa ccagagcaag     2820

aagaccgugu ucguccugac gaagaaguac gcgaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc ugcagcggcu gauggacgag aacauggacg ugaucaucuu cauccuccug     2940

gagcccgugc ugcagcacag ccaguaccuc cgccugcggc agcgcaucug caaguccagc     3000

auccugcagu ggcccgacaa cccgaaggcc gagggccucu ucuggcagac ccugcgcaac     3060

gucgugcuga ccgagaacga cucccgguac aacaacaugu acguggacag caucaagcag     3120

uacuga                                                                3126


<210>  9798
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR8__Homo_sapiens__AAF78036

<400>  9798
auggagaaca uguuccucca guccuccaug cucaccugca ucuuccuccu caucuccggc       60

uccugcgagc ucugcgccga ggagaacuuc ucccgcuccu accccugcga cgagaagaag      120

cagaacgacu ccgucaucgc cgagugcucc aaccgccgcc uccaggaggu cccccagacc      180

gucggcaagu acgucaccga gcucgaccuc uccgacaacu ucaucaccca caucaccaac      240

gaguccuucc agggccucca gaaccucacc aagaucaacc ucaaccacaa ccccaacguc      300

cagcaccaga acggcaaccc cggcauccag uccaacggcc ucaacaucac cgacggcgcc      360

uuccucaacc ucaagaaccu ccgcgagcuc cuccucgagg acaaccagcu cccccagauc      420

cccuccggcc uccccgaguc ccucaccgag cucucccuca uccagaacaa caucuacaac      480

aucaccaagg agggcaucuc ccgccucauc aaccucaaga accucuaccu cgccuggaac      540

ugcuacuuca acaaggucug cgagaagacc aacaucgagg acggcgucuu cgagacccuc      600

accaaccucg agcuccucuc ccucuccuuc aacucccucu cccacguccc ccccaagcuc      660

cccuccuccc uccgcaagcu cuuccucucc aacacccaga ucaaguacau cuccgaggag      720

gacuucaagg gccucaucaa ccucacccuc cucgaccucu ccggcaacug cccccgcugc      780

uucaacgccc ccuuccccug cguccccugc gacggcggcg ccuccaucaa caucgaccgc      840

uucgccuucc agaaccucac ccagcuccgc uaccucaacc ucuccuccac cucccuccgc      900

aagaucaacg ccgccugguu caagaacaug ccccaccuca agguccucga ccucgaguuc      960

aacuaccucg ucggcgagau cgccuccggc gccuuccuca ccaugcuccc ccgccucgag     1020

auccucgacc ucuccuucaa cuacaucaag ggcuccuacc cccagcacau caacaucucc     1080

cgcaacuucu ccaagcuccu cucccuccgc gcccuccacc uccgcggcua cgucuuccag     1140

gagcuccgcg aggacgacuu ccagccccuc augcagcucc ccaaccucuc caccaucaac     1200

cucggcauca acuucaucaa gcagaucgac uucaagcucu uccagaacuu cuccaaccuc     1260

gagaucaucu accucuccga gaaccgcauc uccccccucg ucaaggacac ccgccagucc     1320

uacgccaacu ccuccuccuu ccagcgccac auccgcaagc gccgcuccac cgacuucgag     1380

uucgaccccc acuccaacuu cuaccacuuc acccgccccc ucaucaagcc ccagugcgcc     1440

gccuacggca aggcccucga ccucucccuc aacuccaucu ucuucaucgg ccccaaccag     1500

uucgagaacc uccccgacau cgccugccuc aaccucuccg ccaacuccaa cgcccagguc     1560

cucuccggca ccgaguucuc cgccaucccc cacgucaagu accucgaccu caccaacaac     1620

cgccucgacu ucgacaacgc cuccgcccuc accgagcucu ccgaccucga gguccucgac     1680

cucuccuaca acucccacua cuuccgcauc gccggcguca cccaccaccu cgaguucauc     1740

cagaacuuca ccaaccucaa gguccucaac cucucccaca acaacaucua cacccucacc     1800

gacaaguaca accucgaguc caagucccuc gucgagcucg ucuucuccgg caaccgccuc     1860

gacauccucu ggaacgacga cgacaaccgc uacaucucca ucuucaaggg ccucaagaac     1920

cucacccgcc ucgaccucuc ccucaaccgc cucaagcaca uccccaacga ggccuuccuc     1980

aaccuccccg ccucccucac cgagcuccac aucaacgaca acaugcucaa guucuucaac     2040

uggacccucc uccagcaguu cccccgccuc gagcuccucg accuccgcgg caacaagcuc     2100

cucuuccuca ccgacucccu cuccgacuuc accuccuccc uccgcacccu ccuccucucc     2160

cacaaccgca ucucccaccu ccccuccggc uuccucuccg aggucuccuc ccucaagcac     2220

cucgaccucu ccuccaaccu ccucaagacc aucaacaagu ccgcccucga gaccaagacc     2280

accaccaagc ucuccaugcu cgagcuccac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuucc gccgcuggau ggacgagcac cucaacguca agaucccccg ccucgucgac     2400

gucaucugcg ccucccccgg cgaccagcgc ggcaagucca ucgucucccu cgagcucacc     2460

accugcgucu ccgacgucac cgccgucauc cucuucuucu ucaccuucuu caucaccacc     2520

auggucaugc ucgccgcccu cgcccaccac cucuucuacu gggacgucug guucaucuac     2580

aacgucugcc ucgccaaggu caagggcuac cgcucccucu ccaccuccca gaccuucuac     2640

gacgccuaca ucuccuacga caccaaggac gccuccguca ccgacugggu caucaacgag     2700

cuccgcuacc accucgagga gucccgcgac aagaacgucc uccucugccu cgaggagcgc     2760

gacugggacc ccggccucgc caucaucgac aaccucaugc aguccaucaa ccaguccaag     2820

aagaccgucu ucguccucac caagaaguac gccaaguccu ggaacuucaa gaccgccuuc     2880

uaccucgccc uccagcgccu cauggacgag aacauggacg ucaucaucuu cauccuccuc     2940

gagcccgucc uccagcacuc ccaguaccuc cgccuccgcc agcgcaucug caaguccucc     3000

auccuccagu ggcccgacaa ccccaaggcc gagggccucu ucuggcagac ccuccgcaac     3060

gucguccuca ccgagaacga cucccgcuac aacaacaugu acgucgacuc caucaagcag     3120

uacuga                                                                3126


<210>  9799
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR8__Homo_sapiens__AAF78036

<400>  9799
auggagaaca uguuccugca gagcuccaug uugaccugca ucuuucuucu gauuucuggc       60

ucaugugaau ugugcgccga ggaaaauuuc aguagaagcu accccuguga cgagaagaaa      120

caaaacgauu ccgugauagc ugaaugcucu aauaggcggu uacaggaggu cccucagaca      180

guugggaagu augugacuga gcuggaccua ucggauaacu uuaucacgca cauuaccaau      240

gaaucauucc agggacucca aaaccugaca aaaaucaauc uuaaccauaa uccaaacgua      300

cagcaccaga augguaaccc gggcauucag agcaaugggc ugaacaucac ugacggagca      360

uuuuugaauc ucaagaaccu gcgcgagcug cucuuagaag auaaccaacu gccccagaua      420

ccuaguggcc uuccagaguc cuugaccgag cugucucuaa uccagaauaa cauuuacaau      480

aucacaaaag aagguauuag ccgacucauc aaccugaaga aucuuuaucu ggccuggaac      540

uguuacuuca auaaggugug cgagaaaacc aacauagaag acggggucuu ugagacuuug      600

acaaaucucg aacuguuauc ccugucauuc aacagucuca gccaugugcc cccuaaacuu      660

ccaucuuccc ugcguaaguu guuucuauca aauacccaga uuaaguauau cagcgaggag      720

gauuucaaag gacugauuaa ccucacgcug cuugaccuga guggcaauug ucccagaugc      780

uuuaacgcgc cuuucccaug uguuccgugc gauggcgggg cuucuaucaa uaucgacagg      840

uuugccuucc aaaacuugac ucagcuccgg uaccugaacu uauccagcac cucgcugcgc      900

aagauuaaug cagccugguu caagaacaug ccccaccuaa aagugcucga ucuggaauuu      960

aauuaucuug ucggagagau agcuucuggu gcauucuuga caaugcugcc uagacucgaa     1020

auccuggacc uuuccuuuaa cuacauuaag ggcucauacc cacagcauau caauauaagu     1080

aggaacuuca gcaaacuguu gucccuccgg gcccugcacu uacgcgggua uguguuucaa     1140

gagcugcgag aagaugacuu ccagccccua augcagcucc cuaaucuguc uacuauuaac     1200

cuuggaauca auuuuaucaa gcagauugac uucaaauugu uucaaaacuu cagcaaucug     1260

gagaucauuu accucucaga gaacagaaua aguccacugg uaaaggauac caggcagucc     1320

uaugcuaauu cuucuucauu ucagcggcac auccguaaac gcagaaguac agacuucgaa     1380

uuugaucccc auagcaacuu cuaccacuuc accaggccgu uaauuaagcc ucagugugcc     1440

gcguauggca aggcacugga ccuuuccuug aauagcaucu uuuucaucgg ucccaaccaa     1500

uuugagaacc ucccagauau ugccugccug aaucuaucgg cuaacagcaa ugcccagguu     1560

cuguccggga cggaauuuuc agcaauaccu caugugaaau accucgaccu gacuaacaau     1620

cggcuugauu uugacaacgc uagugccuug acagagcugu cugauuuaga aguccucgac     1680

cugagcuaua auucccacua cuuccgaauc gcgggaguga cccaccaucu ugaguuuauu     1740

cagaacuuca cuaaucugaa gguguugaac cucucacaca auaacaucua cacacugacc     1800

gauaaauaua aucuagagag caagucucug gucgaacucg uuuucuccgg caaccgccug     1860

gacauucuuu ggaaugacga ugacaacaga uacaucagua uauucaaagg cuugaagaac     1920

cugacgaggu uagaucucag ccugaaucgg cuuaagcaua uccccaacga ggccuuucug     1980

aaucuaccag caucucucac cgaacugcac auuaacgaca auauguugaa auucuuuaac     2040

uggacacugu uacagcaauu cccccgccuc gagcugcuug aucugagagg gaauaagcuc     2100

cucuuccuga cugacucccu aucagauuuu accaguagcc ugaggacacu ucuccugucg     2160

cauaaccgua ucucccacuu gccuucugga uuccugagcg aggugucaag uuuaaaacac     2220

cucgaccugu ccucuaaucu ucugaagacu auuaacaaaa gcgcuuugga aaccaagaca     2280

accacuaagc ucuccaugcu ggagcuacau gguaauccau uugaaugcac gugugauauc     2340

ggcgacuucc ggcgauggau ggaugagcac cugaacguaa aaauaccgag acuuguggac     2400

gucauuugcg ccucacccgg ggaucagagg ggaaagagca ucgugagucu cgaacugaca     2460

accuguguuu cugacgugac ugcugucauu uuguuuuucu uuaccuucuu uaucacaacc     2520

auggugaugu uagccgcacu ggcccaucac cucuucuauu gggacguaug guuuauauac     2580

aauguuugcc uggcuaaagu gaagggcuau cgcucccuua gcacuucgca gacauucuac     2640

gaugcguaua ucucauacga cacgaaagau gcaucuguca ccgacugggu gauuaacgag     2700

cugcgguacc acuuggagga aaguagagau aagaaugucc uacugugucu cgaggaaagg     2760

gacugggauc cuggucuggc caucauugac aaccuuaugc aguccaucaa ucaaagcaag     2820

aaaacugugu ucguuuuaac aaagaaauau gcuaagucuu ggaacuuuaa aaccgccuuc     2880

uaccuggcac uccagcgcuu gauggaugag aacauggacg ugauaauuuu uauccugcuc     2940

gaaccaguac ugcagcauag ccaauaucuu cgacugcggc agcguaucug caaguccuca     3000

auuuugcagu ggcccgauaa uccuaaagcc gaggggcuau ucuggcagac acugagaaac     3060

gucgugcuca cugagaauga caguagguac aacaauaugu auguugauag caucaagcaa     3120

uacuga                                                                3126


<210>  9800
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR8__Homo_sapiens__AAF78036

<400>  9800
auggagaaca uguuccugca gagcagcaug cugaccugca ucuuccugcu gaucagcggc       60

agcugcgagc ugugcgccga ggagaacuuc agcagaagcu accccugcga cgagaagaag      120

cagaacgaca gcgugaucgc cgagugcagc aacagaagac ugcaggaggu gccccagacc      180

gugggcaagu acgugaccga gcuggaccug agcgacaacu ucaucaccca caucaccaac      240

gagagcuucc agggccugca gaaccugacc aagaucaacc ugaaccacaa ccccaacgug      300

cagcaccaga acggcaaccc cggcauccag agcaacggcc ugaacaucac cgacggcgcc      360

uuccugaacc ugaagaaccu gagagagcug cugcuggagg acaaccagcu gccccagauc      420

cccagcggcc ugcccgagag ccugaccgag cugagccuga uccagaacaa caucuacaac      480

aucaccaagg agggcaucag cagacugauc aaccugaaga accuguaccu ggccuggaac      540

ugcuacuuca acaaggugug cgagaagacc aacaucgagg acggcguguu cgagacccug      600

accaaccugg agcugcugag ccugagcuuc aacagccuga gccacgugcc ccccaagcug      660

cccagcagcc ugagaaagcu guuccugagc aacacccaga ucaaguacau cagcgaggag      720

gacuucaagg gccugaucaa ccugacccug cuggaccuga gcggcaacug ccccagaugc      780

uucaacgccc ccuuccccug cgugcccugc gacggcggcg ccagcaucaa caucgacaga      840

uucgccuucc agaaccugac ccagcugaga uaccugaacc ugagcagcac cagccugaga      900

aagaucaacg ccgccugguu caagaacaug ccccaccuga aggugcugga ccuggaguuc      960

aacuaccugg ugggcgagau cgccagcggc gccuuccuga ccaugcugcc cagacuggag     1020

auccuggacc ugagcuucaa cuacaucaag ggcagcuacc cccagcacau caacaucagc     1080

agaaacuuca gcaagcugcu gagccugaga gcccugcacc ugagaggcua cguguuccag     1140

gagcugagag aggacgacuu ccagccccug augcagcugc ccaaccugag caccaucaac     1200

cugggcauca acuucaucaa gcagaucgac uucaagcugu uccagaacuu cagcaaccug     1260

gagaucaucu accugagcga gaacagaauc agcccccugg ugaaggacac cagacagagc     1320

uacgccaaca gcagcagcuu ccagagacac aucagaaaga gaagaagcac cgacuucgag     1380

uucgaccccc acagcaacuu cuaccacuuc accagacccc ugaucaagcc ccagugcgcc     1440

gccuacggca aggcccugga ccugagccug aacagcaucu ucuucaucgg ccccaaccag     1500

uucgagaacc ugcccgacau cgccugccug aaccugagcg ccaacagcaa cgcccaggug     1560

cugagcggca ccgaguucag cgccaucccc cacgugaagu accuggaccu gaccaacaac     1620

agacuggacu ucgacaacgc cagcgcccug accgagcuga gcgaccugga ggugcuggac     1680

cugagcuaca acagccacua cuucagaauc gccggcguga cccaccaccu ggaguucauc     1740

cagaacuuca ccaaccugaa ggugcugaac cugagccaca acaacaucua cacccugacc     1800

gacaaguaca accuggagag caagagccug guggagcugg uguucagcgg caacagacug     1860

gacauccugu ggaacgacga cgacaacaga uacaucagca ucuucaaggg ccugaagaac     1920

cugaccagac uggaccugag ccugaacaga cugaagcaca uccccaacga ggccuuccug     1980

aaccugcccg ccagccugac cgagcugcac aucaacgaca acaugcugaa guucuucaac     2040

uggacccugc ugcagcaguu ccccagacug gagcugcugg accugagagg caacaagcug     2100

cuguuccuga ccgacagccu gagcgacuuc accagcagcc ugagaacccu gcugcugagc     2160

cacaacagaa ucagccaccu gcccagcggc uuccugagcg aggugagcag ccugaagcac     2220

cuggaccuga gcagcaaccu gcugaagacc aucaacaaga gcgcccugga gaccaagacc     2280

accaccaagc ugagcaugcu ggagcugcac ggcaaccccu ucgagugcac cugcgacauc     2340

ggcgacuuca gaagauggau ggacgagcac cugaacguga agauccccag acugguggac     2400

gugaucugcg ccagccccgg cgaccagaga ggcaagagca ucgugagccu ggagcugacc     2460

accugcguga gcgacgugac cgccgugauc cuguucuucu ucaccuucuu caucaccacc     2520

auggugaugc uggccgcccu ggcccaccac cuguucuacu gggacgugug guucaucuac     2580

aacgugugcc uggccaaggu gaagggcuac agaagccuga gcaccagcca gaccuucuac     2640

gacgccuaca ucagcuacga caccaaggac gccagcguga ccgacugggu gaucaacgag     2700

cugagauacc accuggagga gagcagagac aagaacgugc ugcugugccu ggaggagaga     2760

gacugggacc ccggccuggc caucaucgac aaccugaugc agagcaucaa ccagagcaag     2820

aagaccgugu ucgugcugac caagaaguac gccaagagcu ggaacuucaa gaccgccuuc     2880

uaccuggccc ugcagagacu gauggacgag aacauggacg ugaucaucuu cauccugcug     2940

gagcccgugc ugcagcacag ccaguaccug agacugagac agagaaucug caagagcagc     3000

auccugcagu ggcccgacaa ccccaaggcc gagggccugu ucuggcagac ccugagaaac     3060

guggugcuga ccgagaacga cagcagauac aacaacaugu acguggacag caucaagcag     3120

uacuga                                                                3126


<210>  9801
<211>  3126
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR8__Homo_sapiens__AAF78036

<400>  9801
auggagaaca uguuccugca gagcuccaug cugaccugca ucuuucugcu uauuucuggc       60

agcugugaac ugugcgccga ggaaaauuuc uccagaucuu accccuguga cgagaagaaa      120

caaaacgaua gcgugaucgc ugaaugcucc aaucggcgcc uccaggaggu cccucagaca      180

guugggaagu augugacgga gcuggaccuu ucugauaacu uuauuaccca caucacaaau      240

gaauccuucc agggacugca aaaccucacc aaaauuaauc ugaaccauaa uccgaacgug      300

cagcaccaga auggcaaccc cgggauccag uccaauggac ugaacaucac agacggcgcc      360

uuucucaauc ugaagaaccu uagagagcug cuccuggaag auaaccaacu uccucagauu      420

cccagcgggc ugccugaguc ucucaccgag cugucccuga uccagaauaa cauuuacaau      480

aucacaaaag aaggaauuag ccggcucauc aaccugaaga aucuuuaucu ggcguggaac      540

uguuacuuca auaaggucug cgagaaaacc aacauugaag acggcguguu ugagacgcuc      600

accaaucugg aacuucuguc ucucuccuuc aacagccugu cucauguucc cccuaagcug      660

ccguccagcc uccgcaaacu guuucuuucc aauacacaga ucaaguauau cucugaggag      720

gauuucaaag gccugauuaa ccucacccug cuugaccuga gcgggaauug ucccagaugc      780

uuuaacgcuc cuuuccccug ugugccuugc gauggaggcg ccuccaucaa uauugaccgg      840

uuugccuucc aaaaccucac acagcugcgc uaccugaacc ucagcucuac cucccugaga      900

aagaucaaug cugccugguu caagaacaug ccccaccuua aaguccugga ucucgaauuu      960

aauuaucugg ugggggagau ugcuagcgga gccuuccuga cgaugcuucc gcggcucgaa     1020

auccuggacc ugucuuuuaa cuacaucaag ggcagcuacc cucagcauau uaauaucucc     1080

cgcaacuucu cuaaacuccu gagccuuaga gcgcugcacc uccgggggua uguuuuucaa     1140

gagcugcgcg aagaugacuu ccagccccug augcagcuuc cuaaucucuc cacaauuaac     1200

cugggaauca auuuuauuaa gcagaucgac uucaaacugu uucaaaacuu cagcaaucuc     1260

gagaucauuu accugucuga gaacagaauc agcccccuug ugaaggauac ccggcagagc     1320

uaugccaauu cuuccagcuu ucagcgccac auuagaaaac ggagauccac agacuucgaa     1380

uuugaucccc auucuaacuu cuaccacuuc acccgcccuc ugaucaagcc gcagugugcu     1440

gccuauggca aggcucucga ccugagccuc aauuccauuu ucuucaucgg ccccaaccaa     1500

uuugagaacc uuccugauau ugccugccuc aaucugucug cgaacagcaa ugcccagguc     1560

cuguccggga ccgaauuuag cgcuaucccc caugugaaau accucgaccu gacaaacaau     1620

cggcuugauu uugacaacgc cucugcucug acggagcucu ccgaucugga agugcuggac     1680

cuuagcuaua auucucacua cuucagaauc gccggaguca cccaccaucu cgaguuuauu     1740

cagaacuuca caaaucugaa gguucugaac cucucccaca auaacaucua cacccugaca     1800

gauaaauaua aucuugagag caagucucug guggaacucg uguuuagcgg caaccgccug     1860

gacauucugu ggaaugacga ugacaaccgg uacaucucca uuuucaaagg gcuuaagaac     1920

cugaccagac ucgaucugag ccucaaucgc cugaagcaua ucccuaacga ggccuuucuu     1980

aaucugcccg cuucucucac ggaacugcac aucaacgaca auaugcugaa auucuuuaac     2040

uggacacuuc ugcagcaauu cccgcggcuc gagcugcucg aucugagagg aaauaaacuu     2100

cuguuccuca ccgacucccu gagcgauuuu accuccucuc ugcgcacacu ucugcucagc     2160

cauaaccgga uuucccaucu gccuucuggc uuccucagcg aggucuccuc ucugaagcac     2220

cuugaccuga gcuccaaucu gcucaagacc aucaacaaaa gcgcgcugga aacaaagacg     2280

accacaaaac uuucuaugcu ggagcuccac gggaaucccu uugaaugcac cugugauauu     2340

ggagacuuca gacgcuggau ggaugagcac cugaacguga agaucccucg gcucguugac     2400

gugauuugcg ccucccccgg cgaucagaga ggcaagagca ucgucucucu ggaacuuaca     2460

accugugugu ccgacguuac ggcugugauc cuguuuuucu uuaccuucuu uauuacaacc     2520

auggucaugc uggccgcccu cgcucaucac cuguucuauu gggacgugug guuuaucuac     2580

aaugucugcc uugccaaagu gaagggguau cggagccugu cuacauccca gaccuucuac     2640

gaugcguaua uuagcuacga cacgaaagau gcuuccguua cagacugggu gaucaacgag     2700

cuccgcuacc accuggagga aagcagagau aagaaugucc uccugugucu ugaggaacgg     2760

gacugggauc cuggacuggc cauuaucgac aaccugaugc agucuaucaa ucaaagcaag     2820

aaaaccgugu ucguucucac aaagaaauau gccaaguccu ggaacuuuaa aaccgcuuuc     2880

uaccuggccc uucagagacu gauggaugag aacauggacg ugauuaucuu uauucuccug     2940

gaacccgucc uccagcauuc ucaauaucug cgccuucggc agagaaucug caagagcucc     3000

auucugcagu ggccggauaa uccuaaagcu gagggccugu ucuggcagac ccuccgcaac     3060

guggugcuga cagagaauga cucuagauac aacaauaugu auguugauag caucaagcaa     3120

uacuga                                                                3126


<210>  9802
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__B6CH46

<400>  9802

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Thr Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln 
        995                 1000                1005            


Leu Gly Met Ala Leu Thr Arg Asp Asn His His Phe Tyr Asn Arg Asn 
    1010                1015                1020                


Phe Cys Gln Gly Pro Thr Ala Glu 
1025                1030        


<210>  9803
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__ABW37074

<400>  9803
auggguuucu gccgcagcgc ccugcacccg cugucucucc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg uaccuugccu gccuuccuac ccugugagcu ccagccccac      120

ggccugguga acugcaacug gcuguuccug aagucugugc cccacuucuc cacggcagca      180

ccccguggca augucaccag ccuuuccuug uccuccaacc gcauccacca ccuccaugau      240

ucugacuuug cccaccugcc cagccugcgg caucucaacc ucaaguggaa cugcccgccg      300

guuggccuca gccccaugca cuuccccugc cacaugacca ucgagcccag caccuucuug      360

gcugugccca cccuggaaga gcuaaaccug agcuacaaca acaucaugac ugugccugcg      420

cugcccaaau cccucauauc ccugucccuc agccauacca acauccugau gcuagacucu      480

gccagccucg ccggccugca ugcccugcgc uuccuauuca uggacggcaa cuguuauuac      540

aagaaccccu gcaggcaggc acuggaggug gccccgggug cccuccuugg ccugggcaac      600

cucacccacc ugucacucaa guacaacaac cucacugugg ugccccgcaa ccugccuucc      660

agccuggagu aucugcuguu guccuacaac cgcaucguca aacuggcgcc ugaggaccug      720

gccaaucuga ccgcccugcg ugugcucgau gugggcggaa auugccgccg cugcgaccac      780

gcucccaacc ccugcaugga gugcccucgu cacuuccccc agcuacaucc cgauaccuuc      840

agccaccuga gccgucuuga aggccuggug uugaaggaca guucucucuc cuggcugaau      900

gccaguuggu uccgugggcu gggaaaccuc cgagugcugg accugaguga gaacuuccuc      960

uacaaaugca ucacuaaaac caaggccuuc cagggccuaa cacagcugcg caagcuuaac     1020

cuguccuuca auuaccaaaa gagggugucc uuugcccacc ugucucuggc cccuuccuuc     1080

gggagccugg ucgcccugaa ggagcuggac augcacggca ucuucuuccg cucacucgau     1140

gagaccacgc uccggccacu ggcccgccug cccaugcucc agacucugcg ucugcagaug     1200

aacuucauca accaggccca gcucggcauc uucagggccu ucccuggccu gcgcuacgug     1260

gaccugucgg acaaccgcau cagcggagcu ucggagcuga cagccaccau gggggaggca     1320

gauggagggg agaaggucug gcugcagccu ggggaccuug cuccggcccc aguggacacu     1380

cccagcucug aagacuucag gcccaacugc agcacccuca acuucaccuu ggaucuguca     1440

cggaacaacc uggugaccgu gcagccggag auguuugccc agcucucgca ccugcagugc     1500

cugcgccuga gccacaacug caucucgcag gcagucaaug gcucccaguu ccugccgcug     1560

accggucugc aggugcuaga ccugucccac aauaagcugg accucuacca cgagcacuca     1620

uucacggagc uaccgcgacu ggaggcccug gaccucagcu acaacagcca gcccuuuggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcucacc ugcgcacccu gcgccaccuc     1740

agccuggccc acaacaacau ccacagccaa gugucccagc agcucugcag uacgucgcug     1800

cgggcccugg acuucagcgg caaugcacug ggccauaugu gggccgaggg agaccucuau     1860

cugcacuucu uccaaggccu gagcgguuug aucuggcugg acuuguccca gaaccgccug     1920

cacacccucc ugccccaaac ccugcgcaac cuccccaaga gccuacaggu gcugcgucuc     1980

cgugacaauu accuggccuu cuuuaagugg uggagccucc acuuccugcc caaacuggaa     2040

guccucgacc uggcaggaaa ccagcugaag gcccugacca auggcagccu gccugcuggc     2100

acccggcucc ggaggcugga ugucagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uuuuccaagg ccaaggagcu gcgagagcuc aaccuuagcg ccaacgcccu caagacagug     2220

gaccacuccu gguuugggcc ccuggcgagu gcccugcaaa uacuagaugu aagcgccaac     2280

ccucugcacu gcgccugugg ggcggccuuu auggacuucc ugcuggaggu gcaggcugcc     2340

gugcccgguc ugcccagccg ggugaagugu ggcaguccgg gccagcucca gggccucagc     2400

aucuuugcac aggaccugcg ccucugccug gaugaggccc ucuccuggga cuguuucgcc     2460

cucucgcugc uggcuguggc ucugggccug ggugugccca ugcugcauca ccucuguggc     2520

ugggaccucu gguacugcuu ccaccugugc cuggccuggc uucccuggcg ggggcggcaa     2580

agugggcgag augaggaugc ccugcccuac gaugccuucg uggucuucga caaaacgcag     2640

agcgcagugg cagacugggu guacaacgag cuucgggggc agcuggagga gugccguggg     2700

cgcugggcac uccgccugug ccuggaggaa cgcgacuggc ugccuggcaa aacccucuuu     2760

gagaaccugu gggccucggu cuauggcagc cgcaagacgc uguuugugcu ggcccacacg     2820

gaccggguca guggucucuu gcgcgccagc uuccugcugg cccagcagcg ccugcuggag     2880

gaccgcaagg acgucguggu gcuggugauc cugagcccug acggccgccg cucccgcuac     2940

gugcggcugc gccagcgccu cugccgccag aguguccucc ucuggcccca ccagcccagu     3000

ggucagcgca gcuucugggc ccagcugggc auggcccuga ccagggacaa ccaccacuuc     3060

uauaaccgga acuucugcca gggacccacg gccgaauag                            3099


<210>  9804
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__ABW37074

<400>  9804
augggcuucu gccgcagcgc ccugcacccc cucucccugc uggugcaggc caucaugcuc       60

gcgaugaccc uggcccuggg gacccucccg gccuuccugc ccugcgagcu gcagccccac      120

ggccucguca acugcaacug gcuguuccuc aagagcgugc cccacuucuc cacggccgcc      180

ccgcggggga acgugaccag ccugucccug agcuccaacc gcauccacca ccuccacgac      240

agcgacuucg cgcaccuccc cucccugcgg caccugaacc ugaaguggaa cugcccgccc      300

gucggccuga gccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccug      360

gccgugccca cgcucgagga gcugaaccug agcuacaaca acaucaugac cgugccggcc      420

cuccccaagu cccugaucag ccugucccuc agccacacca acauccugau gcuggacucc      480

gccagccucg cggggcugca cgcccugcgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccggcaggc ccuggagguc gcccccggcg cccugcucgg gcugggcaac      600

cugacccacc ucucccugaa guacaacaac cugacggugg ugccgcgcaa ccuccccagc      660

agccuggagu accugcuccu guccuacaac cggaucguca agcuggcgcc cgaggaccuc      720

gccaaccuga ccgcccugcg cgugcuggac gucgggggca acugccggcg cugcgaccac      780

gcccccaacc cgugcaugga gugcccccgg cacuuccccc agcuccaccc cgacaccuuc      840

agccaccugu cccgccugga ggggcucgug cugaaggaca gcucccugag cuggcucaac      900

gccuccuggu uccggggccu gggcaaccug cgcgugcucg accugagcga gaacuuccug      960

uacaagugca ucaccaagac gaaggcguuc caggggcuca cccagcugcg gaagcugaac     1020

cucuccuuca acuaccagaa gcgcgugagc uucgcccacc ugucccuggc cccgagcuuc     1080

ggcucccucg ucgcccugaa ggagcuggac augcacggga ucuucuuccg gagccucgac     1140

gagaccaccc ugcgcccccu ggcccggcuc cccaugcugc agacgcugcg ccuccagaug     1200

aacuucauca accaggcgca gcugggcauc uuccgggccu uccccggccu gcgcuacgug     1260

gaccucuccg acaaccgcau cagcggggcc uccgagcuga ccgccaccau gggcgaggcc     1320

gacgggggcg agaaggugug gcugcagccg ggggaccucg cgcccgcccc cgucgacacc     1380

ccgagcuccg aggacuuccg gcccaacugc agcacgcuga acuucacccu ggaccucagc     1440

cgcaacaacc uggugaccgu gcagcccgag auguucgccc agcuguccca ccuccagugc     1500

cugcggcuga gccacaacug caucucccag gccgucaacg gcagccaguu ccucccccug     1560

accggccucc aggugcugga ccugucccac aacaagcugg accucuacca cgagcacagc     1620

uucacggagc ugccgcgccu ggaggcgcuc gaccuguccu acaacagcca gcccuucggg     1680

augcagggcg uggggcacaa cuucuccuuc gucgcccacc uccggacccu gcgccaccug     1740

agccuggccc acaacaacau ccacucccag gugagccagc agcucugcuc caccagccug     1800

cgggcccugg acuucuccgg caacgcccuc gggcacaugu gggcggaggg cgaccuguac     1860

cugcacuucu uccagggccu cagcgggcug aucuggcugg accucuccca gaaccgccug     1920

cacacccugc ucccccagac gcugcggaac cugcccaaga gccuccaggu ccugcgccug     1980

cgggacaacu accucgccuu cuucaagugg uggagccugc acuuccugcc gaagcucgag     2040

gugcuggacc uggccggcaa ccagcucaag gcccugacca acgggucccu gcccgccggc     2100

acccgccucc ggcgccugga cgugagcugc aacuccauca gcuucgucgc gcccggguuc     2160

uucuccaagg ccaaggagcu gcgggagcuc aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacuccu gguucggccc ccucgccagc gcgcugcaga uccuggacgu guccgccaac     2280

ccgcuccacu gcgccugcgg cgccgcguuc auggacuucc ugcuggaggu ccaggccgcc     2340

gugcccgggc ugcccagccg cgugaagugc ggcucccccg ggcagcucca gggccugagc     2400

aucuucgccc aggaccugcg gcucugccug gacgaggccc uguccuggga cugcuucgcg     2460

cucagccugc uggccgucgc ccucggccug ggggugccga ugcugcacca ccucugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cucgccuggc ugcccuggcg cgggcggcag     2580

uccggccgcg acgaggacgc ccugcccuac gacgcguucg uggucuucga caagacgcag     2640

agcgccgugg ccgacugggu guacaacgag cuccgcgggc agcuggagga gugccggggc     2700

cgcugggccc ugcggcucug ccuggaggag cgcgacuggc ugcccggcaa gacccucuuc     2760

gagaaccugu gggccuccgu cuacgggagc cggaagaccc uguucgugcu cgcgcacacc     2820

gaccgcgugu ccggccugcu gcgggccagc uuccuccugg cccagcagcg ccugcucgag     2880

gaccggaagg acgucguggu gcuggucauc cugagcccgg acgggcgccg gucccgcuac     2940

gugcggcucc gccagcggcu gugccgccag agcgugcugc ucuggcccca ccagcccucc     3000

ggccagcgga gcuucugggc ccagcugggg auggcgcuga cgcgcgacaa ccaccacuuc     3060

uacaaccgga acuucugcca gggccccacc gccgaguga                            3099


<210>  9805
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__ABW37074

<400>  9805
augggcuucu gccgcuccgc ccuccacccc cucucccucc ucguccaggc caucaugcuc       60

gccaugaccc ucgcccucgg cacccucccc gccuuccucc ccugcgagcu ccagccccac      120

ggccucguca acugcaacug gcucuuccuc aaguccgucc cccacuucuc caccgccgcc      180

ccccgcggca acgucaccuc ccucucccuc uccuccaacc gcauccacca ccuccacgac      240

uccgacuucg cccaccuccc cucccuccgc caccucaacc ucaaguggaa cugccccccc      300

gucggccucu cccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccuc      360

gccgucccca cccucgagga gcucaaccuc uccuacaaca acaucaugac cguccccgcc      420

cuccccaagu cccucaucuc ccucucccuc ucccacacca acauccucau gcucgacucc      480

gccucccucg ccggccucca cgcccuccgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccgccaggc ccucgagguc gcccccggcg cccuccucgg ccucggcaac      600

cucacccacc ucucccucaa guacaacaac cucaccgucg ucccccgcaa ccuccccucc      660

ucccucgagu accuccuccu cuccuacaac cgcaucguca agcucgcccc cgaggaccuc      720

gccaaccuca ccgcccuccg cguccucgac gucggcggca acugccgccg cugcgaccac      780

gcccccaacc ccugcaugga gugcccccgc cacuuccccc agcuccaccc cgacaccuuc      840

ucccaccucu cccgccucga gggccucguc cucaaggacu ccucccucuc cuggcucaac      900

gccuccuggu uccgcggccu cggcaaccuc cgcguccucg accucuccga gaacuuccuc      960

uacaagugca ucaccaagac caaggccuuc cagggccuca cccagcuccg caagcucaac     1020

cucuccuuca acuaccagaa gcgcgucucc uucgcccacc ucucccucgc ccccuccuuc     1080

ggcucccucg ucgcccucaa ggagcucgac augcacggca ucuucuuccg cucccucgac     1140

gagaccaccc uccgcccccu cgcccgccuc cccaugcucc agacccuccg ccuccagaug     1200

aacuucauca accaggccca gcucggcauc uuccgcgccu uccccggccu ccgcuacguc     1260

gaccucuccg acaaccgcau cuccggcgcc uccgagcuca ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggucug gcuccagccc ggcgaccucg cccccgcccc cgucgacacc     1380

cccuccuccg aggacuuccg ccccaacugc uccacccuca acuucacccu cgaccucucc     1440

cgcaacaacc ucgucaccgu ccagcccgag auguucgccc agcucuccca ccuccagugc     1500

cuccgccucu cccacaacug caucucccag gccgucaacg gcucccaguu ccucccccuc     1560

accggccucc agguccucga ccucucccac aacaagcucg accucuacca cgagcacucc     1620

uucaccgagc ucccccgccu cgaggcccuc gaccucuccu acaacuccca gcccuucggc     1680

augcagggcg ucggccacaa cuucuccuuc gucgcccacc uccgcacccu ccgccaccuc     1740

ucccucgccc acaacaacau ccacucccag gucucccagc agcucugcuc caccucccuc     1800

cgcgcccucg acuucuccgg caacgcccuc ggccacaugu gggccgaggg cgaccucuac     1860

cuccacuucu uccagggccu cuccggccuc aucuggcucg accucuccca gaaccgccuc     1920

cacacccucc ucccccagac ccuccgcaac cuccccaagu cccuccaggu ccuccgccuc     1980

cgcgacaacu accucgccuu cuucaagugg uggucccucc acuuccuccc caagcucgag     2040

guccucgacc ucgccggcaa ccagcucaag gcccucacca acggcucccu ccccgccggc     2100

acccgccucc gccgccucga cgucuccugc aacuccaucu ccuucgucgc ccccggcuuc     2160

uucuccaagg ccaaggagcu ccgcgagcuc aaccucuccg ccaacgcccu caagaccguc     2220

gaccacuccu gguucggccc ccucgccucc gcccuccaga uccucgacgu cuccgccaac     2280

ccccuccacu gcgccugcgg cgccgccuuc auggacuucc uccucgaggu ccaggccgcc     2340

guccccggcc uccccucccg cgucaagugc ggcucccccg gccagcucca gggccucucc     2400

aucuucgccc aggaccuccg ccucugccuc gacgaggccc ucuccuggga cugcuucgcc     2460

cucucccucc ucgccgucgc ccucggccuc ggcgucccca ugcuccacca ccucugcggc     2520

ugggaccucu gguacugcuu ccaccucugc cucgccuggc uccccuggcg cggccgccag     2580

uccggccgcg acgaggacgc ccuccccuac gacgccuucg ucgucuucga caagacccag     2640

uccgccgucg ccgacugggu cuacaacgag cuccgcggcc agcucgagga gugccgcggc     2700

cgcugggccc uccgccucug ccucgaggag cgcgacuggc uccccggcaa gacccucuuc     2760

gagaaccucu gggccuccgu cuacggcucc cgcaagaccc ucuucguccu cgcccacacc     2820

gaccgcgucu ccggccuccu ccgcgccucc uuccuccucg cccagcagcg ccuccucgag     2880

gaccgcaagg acgucgucgu ccucgucauc cucucccccg acggccgccg cucccgcuac     2940

guccgccucc gccagcgccu cugccgccag uccguccucc ucuggcccca ccagcccucc     3000

ggccagcgcu ccuucugggc ccagcucggc auggcccuca cccgcgacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacc gccgaguga                            3099


<210>  9806
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__ABW37074

<400>  9806
augggcuucu gcagaagcgc ccugcacccc cucucccuuc uggugcaggc uaucauguug       60

gcaaugaccu uagcccuggg gacacuaccu gcguuucucc caugugagcu gcaaccgcau      120

ggacuuguca acugcaauug gcuguucuug aagucuguuc cccacuuuuc aacugcugcc      180

ccuaggggua acgugacgag ucucagccug uccucuaauc ggauucauca ccuucaugac      240

ucggauuucg cacaccuccc aucauuacgc caccugaacc uuaaauggaa uugucccccu      300

guaggcuuga gcccaaugca uuuucccugc cacaugacca uagaaccuag uacauuccug      360

gccgugccaa cucuagagga acucaaccug uccuacaaua acaucaugac cgucccggcu      420

cugcccaagu cucugauuag cuugucccuc ucacauacaa auauccugau guuagacagu      480

gcaagccugg ccgggcucca cgcucugcga uuucuguuca uggauggaaa cuguuauuac      540

aaaaauccuu gccgucaggc cuuggaggug gcgccaggcg cacuacuggg ucucgggaac      600

cugacccacc uuucucugaa guauaauaac uugacuguug ugcccagaaa ucucccuucc      660

ucacuggaau acuuacugcu aagcuauaac aggauuguca aacucgcccc agaggaccug      720

gcuaaccuua cagccuugcg ggugcuggau guaggaggca auugucgcag augcgaccau      780

gcacccaacc cguguaugga gugcccuagg cacuuucccc agcuccaucc agauaccuuc      840

agucaccugu cucggcuuga aggccugguu uugaaggacu ccagccucuc guggcugaau      900

gcuucuuggu uucgcggguu aggaaaccug cgagugcuag aucucuccga gaauuuccug      960

uacaagugua ucacgaaaac uaaggccuuu cagggucuua cccaauugag aaaacugaac     1020

cucucauuca auuaucagaa gagggucagu uucgcgcauc ugagcuuagc cccuuccuuu     1080

ggcucucugg uggcacuuaa agaauuggac augcacggga uauucuuucg gagccucgau     1140

gagacaacuc ugcguccccu agcucgccug ccaaugcucc agacccugag acuucagaug     1200

aacuucauca aucaagccca guugggaauu uuuagggcuu uccccggccu gcgguacgug     1260

gacuuaucag auaaccgaau caguggugcc uccgagcuca cagcaaccau gggggaagcc     1320

gacggaggcg agaaggucug gcugcagccu ggcgaccuug cuccagcgcc gguugauacg     1380

cccagcucug aagacuuucg cccuaauugc ucaacucuga acuucacauu ggaucucagu     1440

agaaauaacc uggugaccgu acagccagag auguuugcac aacuaagcca ccuucagugc     1500

cucaggcugu cccauaauug uauuucucag gccgugaacg ggucgcaauu ccuucccuug     1560

acuggacugc aggucuuaga ccucagccac aacaagcugg aucuuuacca ugaacacucc     1620

uuuacagagc ugccucggcu agaggcucuc gaccugucau auaauaguca gccauucggu     1680

augcagggcg uggggcacaa cuuuucuuuc guugcccauu ugcgcacccu gagacacuua     1740

agccucgcac auaauaacau ccacucccaa gugucacagc agcugugcag cacgucucuu     1800

agggcccugg auuucuccgg aaaugcuuug ggccauaugu gggccgaagg ugaccucuac     1860

cugcacuuuu uccaggggcu aaguggccug auauggcuug aucucagcca aaaccgucug     1920

cacaccuugc ugccccagac auuacggaau cucccgaaau cucugcaggu ccuucgacug     1980

agagacaacu auuuggcauu uuucaagugg uggucccucc auuuucugcc uaaacuagag     2040

gugcuggauc uugcgggaaa ucagcucaag gcucugacua acggcucauu gccagccggg     2100

accagguuac gccggcugga cguaaguugu aauagcauuu cguucguugc acccggauuu     2160

uucuccaaag ccaaggaacu cagagagcug aaccuuucug cuaaugcccu gaaaacagug     2220

gaccacagcu gguuuggucc uuuggcauca gcucuacaaa uccuggaugu cagugccaac     2280

ccccuccauu gcgcgugugg cgccgcuuuc auggacuuuc ugcuugaagu gcaggcagcc     2340

gucccagggu uaccuuccag ggugaagugc ggaucucccg gccagcugca gggucucagc     2400

auuuucgcuc aagauuugcg ccugugucuc gacgaggccc uguccuggga uugcuuugca     2460

cuuucacugu uggcgguugc ccuagggcug ggcgugccaa ugcuccacca uuuaugugga     2520

ugggaccugu gguacugcuu ccaccuuugu cuggcuuggc ucccguggcg aggccggcag     2580

agcgggcgug augaggacgc cuugccuuau gaugcauucg uagucuuuga caagacucag     2640

agugcugugg ccgauugggu uuacaaugaa cugagaggac aacucgagga augcaggggu     2700

cgcugggcac ugcggcuuug ccuagaggaa agagacuggc ugcccggcaa aaccuuguuc     2760

gagaacuuau gggccucugu guaugggucc aggaagacac uguuuguccu cgcucacacc     2820

gaucgaguga gcggacugcu ucgcgcgucg uuccugcucg cccagcagcg guugcuggag     2880

gacagaaaag acguaguggu ucuagucauc cugucaccag auggcaggcg uucucgcuac     2940

gugcggcuca gacagaggcu uugucgacaa agugugcugu uauggcccca ucagccuucc     3000

ggucagcgga gcuuuugggc acaguugggg auggcucuga cucgcgacaa ccaccauuuc     3060

uacaauagaa acuuuugcca aggcccaacg gccgaauga                            3099


<210>  9807
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__ABW37074

<400>  9807
augggcuucu gcagaagcgc ccugcacccc cugagccugc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg cacccugccc gccuuccugc ccugcgagcu gcagccccac      120

ggccugguga acugcaacug gcuguuccug aagagcgugc cccacuucag caccgccgcc      180

cccagaggca acgugaccag ccugagccug agcagcaaca gaauccacca ccugcacgac      240

agcgacuucg cccaccugcc cagccugaga caccugaacc ugaaguggaa cugccccccc      300

gugggccuga gccccaugca cuuccccugc cacaugacca ucgagcccag caccuuccug      360

gccgugccca cccuggagga gcugaaccug agcuacaaca acaucaugac cgugcccgcc      420

cugcccaaga gccugaucag ccugagccug agccacacca acauccugau gcuggacagc      480

gccagccugg ccggccugca cgcccugaga uuccuguuca uggacggcaa cugcuacuac      540

aagaaccccu gcagacaggc ccuggaggug gcccccggcg cccugcuggg ccugggcaac      600

cugacccacc ugagccugaa guacaacaac cugaccgugg ugcccagaaa ccugcccagc      660

agccuggagu accugcugcu gagcuacaac agaaucguga agcuggcccc cgaggaccug      720

gccaaccuga ccgcccugag agugcuggac gugggcggca acugcagaag augcgaccac      780

gcccccaacc ccugcaugga gugccccaga cacuuccccc agcugcaccc cgacaccuuc      840

agccaccuga gcagacugga gggccuggug cugaaggaca gcagccugag cuggcugaac      900

gccagcuggu ucagaggccu gggcaaccug agagugcugg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggccuuc cagggccuga cccagcugag aaagcugaac     1020

cugagcuuca acuaccagaa gagagugagc uucgcccacc ugagccuggc ccccagcuuc     1080

ggcagccugg uggcccugaa ggagcuggac augcacggca ucuucuucag aagccuggac     1140

gagaccaccc ugagaccccu ggccagacug cccaugcugc agacccugag acugcagaug     1200

aacuucauca accaggccca gcugggcauc uucagagccu uccccggccu gagauacgug     1260

gaccugagcg acaacagaau cagcggcgcc agcgagcuga ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggugug gcugcagccc ggcgaccugg cccccgcccc cguggacacc     1380

cccagcagcg aggacuucag acccaacugc agcacccuga acuucacccu ggaccugagc     1440

agaaacaacc uggugaccgu gcagcccgag auguucgccc agcugagcca ccugcagugc     1500

cugagacuga gccacaacug caucagccag gccgugaacg gcagccaguu ccugccccug     1560

accggccugc aggugcugga ccugagccac aacaagcugg accuguacca cgagcacagc     1620

uucaccgagc ugcccagacu ggaggcccug gaccugagcu acaacagcca gcccuucggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcccacc ugagaacccu gagacaccug     1740

agccuggccc acaacaacau ccacagccag gugagccagc agcugugcag caccagccug     1800

agagcccugg acuucagcgg caacgcccug ggccacaugu gggccgaggg cgaccuguac     1860

cugcacuucu uccagggccu gagcggccug aucuggcugg accugagcca gaacagacug     1920

cacacccugc ugccccagac ccugagaaac cugcccaaga gccugcaggu gcugagacug     1980

agagacaacu accuggccuu cuucaagugg uggagccugc acuuccugcc caagcuggag     2040

gugcuggacc uggccggcaa ccagcugaag gcccugacca acggcagccu gcccgccggc     2100

accagacuga gaagacugga cgugagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uucagcaagg ccaaggagcu gagagagcug aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacagcu gguucggccc ccuggccagc gcccugcaga uccuggacgu gagcgccaac     2280

ccccugcacu gcgccugcgg cgccgccuuc auggacuucc ugcuggaggu gcaggccgcc     2340

gugcccggcc ugcccagcag agugaagugc ggcagccccg gccagcugca gggccugagc     2400

aucuucgccc aggaccugag acugugccug gacgaggccc ugagcuggga cugcuucgcc     2460

cugagccugc uggccguggc ccugggccug ggcgugccca ugcugcacca ccugugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cuggccuggc ugcccuggag aggcagacag     2580

agcggcagag acgaggacgc ccugcccuac gacgccuucg ugguguucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cugagaggcc agcuggagga gugcagaggc     2700

agaugggccc ugagacugug ccuggaggag agagacuggc ugcccggcaa gacccuguuc     2760

gagaaccugu gggccagcgu guacggcagc agaaagaccc uguucgugcu ggcccacacc     2820

gacagaguga gcggccugcu gagagccagc uuccugcugg cccagcagag acugcuggag     2880

gacagaaagg acgugguggu gcuggugauc cugagccccg acggcagaag aagcagauac     2940

gugagacuga gacagagacu gugcagacag agcgugcugc uguggcccca ccagcccagc     3000

ggccagagaa gcuucugggc ccagcugggc auggcccuga ccagagacaa ccaccacuuc     3060

uacaacagaa acuucugcca gggccccacc gccgaguga                            3099


<210>  9808
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__ABW37074

<400>  9808
augggcuucu gcagaagcgc ccugcacccc cucucccugc uugugcaggc uaucaugcug       60

gccaugaccc ucgcgcuggg gacacuuccu gcuuuucugc cgugugagcu ccaaccccau      120

ggacugguca acugcaauug gcuguuccuc aagucuguuc cucacuuuag cacggccgcu      180

ccccggggca acgugaccuc ccugucucuu agcuccaauc gcauucauca ucugcacgac      240

ucugauuucg cucaccuccc uagccugaga caccuuaacc ugaaauggaa uugucccccu      300

guggggcucu ccccgaugca uuuucccugc cacaugacaa ucgaaccuag caccuuccug      360

gccgucccca cacuggagga acucaaccug ucuuacaaua acauuaugac cgugccugcu      420

cugcccaagu cccugaucag ccucucucug ucccauacaa auauucuuau gcuggacagc      480

gccucucucg cgggacugca cgcccugcgg uuucucuuca uggauggcaa cuguuauuac      540

aaaaauccgu gccgccaggc ucuggagguu gccccugggg cccuucuggg acucggcaac      600

cugacccacc uuucccugaa guauaauaac cucacggugg uccccagaaa ucugccuagc      660

ucccuggaau accuccugcu uucuuauaac cggaucguga aacuggcccc cgaggaccuc      720

gcgaaccuga ccgcccugcg cguucuugau gugggcggga auuguagacg gugcgaccau      780

gcucccaacc cuuguaugga gugcccgcgc cacuuucccc agcuccaucc ugauacauuc      840

agccaccugu ccagacugga aggacucguc cugaaggaca gcucucuuuc cuggcugaau      900

gccagcuggu uucggggccu cgggaaccug cgcgugcugg aucuuucuga gaauuuccuc      960

uacaagugua ucaccaaaac aaaggcuuuu cagggacuga cccaacugag aaaacucaac     1020

cugagcuuca auuaucagaa gcgggugucc uucgcccauc uuucucuggc ccccagcuuu     1080

ggcucccucg ucgcucugaa agaacuggac augcacggga uuuucuuucg cagccuugau     1140

gagacgacac ucagaccucu ggcgcggcug cccaugcucc agacccugag acuucagaug     1200

aacuucauca aucaagccca gcugggaauu uuucgcgcuu ucccgggccu ccgguacguu     1260

gaccugucug auaacagaau cuccggcgcc agcgagcuga cagccaccau gggggaagcu     1320

gacggaggcg agaaggugug gcuucagccu ggggaccucg cccccgcgcc uguggauacc     1380

cccucuuccg aagacuuucg cccuaauugc agcacacuga acuucacgcu ggaucucucc     1440

cggaauaacc uggucaccgu gcagcccgag auguuugcuc aacuuucuca ucugcagugc     1500

cucagacuga gccacaauug uauuucccag gccguuaacg gaucucaauu ccugccgcuu     1560

acaggccuuc aggugcucga ccugagccac aacaagcucg aucuguacca ugaacacucc     1620

uuuaccgagc uuccucgccu ggaggcccuc gaccugagcu auaauucuca gcccuucggg     1680

augcagggag ucggccacaa cuuuuccuuc guggcucauc ugcggacacu uagacaccug     1740

agccucgccc auaauaacau ccacucucaa guuucccagc agcugugcag caccucucuc     1800

cgcgcucugg auuucagcgg caaugcccuu gggcauaugu gggcggaagg agaccuguac     1860

cuccacuuuu uccagggccu guccgggcug auuuggcuug aucugagcca aaaccggcuc     1920

cacacgcugc ucccccagac acugagaaau cuuccuaaau cucuccaggu gcugcgccug     1980

cgggacaacu aucuggccuu uuucaagugg uggucccuuc auuuucugcc gaaacucgag     2040

guccuggauc ucgcuggaaa ucagcugaag gcccuuacca acggcagccu gcccgcuggg     2100

accagacugc ggcgccucga cguguccugu aauucuauca gcuucgucgc cccuggcuuu     2160

uucuccaaag cgaaggaacu gagagagcuu aaccugucug ccaaugcucu caaaacagug     2220

gaccacagcu gguuuggacc ccuggccucc gcucuccaaa uccuggaugu uucugccaac     2280

ccucuucauu gcgccugugg cgcugcguuc auggacuuuc ugcuggaagu gcaggccgcu     2340

guccccgggc ucccuagccg ggugaagugc ggaucccccg gccagcugca ggggcuuagc     2400

auuuucgccc aagaucugag acucugucug gacgaggccc ucucuuggga uugcuuugcu     2460

cugucccuuc uggccguugc gcugggacuc ggcgugccga ugcugcacca ucuuuguggg     2520

ugggaccugu gguacugcuu ccaccucugu cuggcuuggc ugccuuggcg cggccggcag     2580

agcggaagag augaggacgc ccuccccuau gaugccuucg ucguguuuga caagacccag     2640

ucugcugugg ccgauugggu uuacaaugaa cuucgcggcc aacuggagga augcagaggg     2700

cggugggcgc ugcgccucug ccuggaggaa agagacuggc uuccuggaaa aacacuguuc     2760

gagaaccucu gggcuuccgu cuauggcagc cggaagacgc uguuugugcu ggcccacacc     2820

gaucgcgugu cugggcuccu uagagccucc uuccugcugg cucagcagcg gcuccuggag     2880

gaccgcaaag acgucguggu ucuugugauc cugagccccg auggaagacg gucccgcuac     2940

gucagacucc ggcagagacu gugucgccaa agcgugcugc ucuggccgca ucagccuucu     3000

ggccagcgga gcuuuugggc ccagcuuggg auggcucuga caagagacaa ccaccauuuc     3060

uacaaucgca acuuuugcca aggccccacc gccgaauga                            3099


<210>  9809
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__D1CS61

<400>  9809

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu His Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln 
        995                 1000                1005            


Leu Gly Met Ala Leu Thr Arg Asp Asn His His Phe Tyr Asn Arg Asn 
    1010                1015                1020                


Phe Cys Gln Gly Pro Thr Ala Glu 
1025                1030        


<210>  9810
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__AAZ95518

<400>  9810
auggguuucu gccgcagcgc ccugcacccg cugucucucc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg uaccuugccu gccuuccuac ccugugagcu ccagccccac      120

ggccugguga acugcaacug gcuguuccug aagucugugc cccacuucuc cauggcagca      180

ccccguggca augucaccag ccuuuccuug uccuccaacc gcauccacca ccuccaugau      240

ucugacuuug cccaccugcc cagccugcgg caucucaacc ucaaguggaa cugcccgccg      300

guuggccuca gccccaugca cuuccccugc cacaugacca ucgagcccag caccuucuug      360

gcugugccca cccuggaaga gcuaaaccug agcuacaaca acaucaugac ugugccugcg      420

cugcccaaau cccucauauc ccugucccuc agccauacca acauccugau gcuagacucu      480

gccagccucg ccggccugca ugcccugcgc uuccuauuca uggacggcaa cuguuauuac      540

aagaaccccu gcaggcaggc acuggaggug gccccgggug cccuccuugg ccugggcaac      600

cucacccacc ugucacucaa guacaacaac cucacugugg ugccccgcaa ccugccuucc      660

agccuggagu aucugcuguu guccuacaac cgcaucguca aacuggcgcc ugaggaccug      720

gccaaucuga ccgcccugcg ugugcucgau gugggcggaa auugccgccg cugcgaccac      780

gcucccaacc ccugcaugga gugcccucgu cacuuccccc agcuacaucc cgauaccuuc      840

agccaccuga gccgucuuga aggccuggug uugaaggaca guucucucuc cuggcugaau      900

gccaguuggu uccgugggcu gggaaaccuc cgagugcugg accugaguga gaacuuccuc      960

uacaaaugca ucacuaaaac caaggccuuc cagggccuaa cacagcugcg caagcuuaac     1020

cuguccuuca auuaccaaaa gagggugucc uuugcccacc ugucucuggc cccuuccuuc     1080

gggagccugg ucgcccugaa ggagcuggac augcacggca ucuucuuccg cucacucgau     1140

gagaccacac uccggccacu ggcccgccug cccaugcucc agacucugcg ucugcagaug     1200

aacuucauca accaggccca gcucggcauc uucagggccu ucccuggccu gcgcuacgug     1260

gaccugucgg acaaccgcau cagcggagcu ucggagcuga cagccaccau gggggaggca     1320

gauggagggg agaaggucug gcugcagccu ggggaccuug cuccggcccc aguggacacu     1380

cccagcucug aagacuucag gcccaacugc agcacccuca acuucaccuu ggaucuguca     1440

cggaacaacc uggugaccgu gcagccggag auguuugccc agcucucgca ccugcagugc     1500

cugcgccuga gccacaacug caucucacag gcagucaaug gcucccaguu ccugccgcug     1560

accggucugc aggugcuaga ccugucccac aauaagcugg accucuacca cgagcacuca     1620

uucacggagc uaccgcgacu ggaggcccug gaccucagcu acaacagcca gcccuuuggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcucacc ugcgcacccu gcgccaccuc     1740

agccuggccc acaacaacau ccacagccaa gugucccagc agcucugcag uacgucgcug     1800

cgggcccugg acuucagcgg caaugcacug ggccauaugu gggccgaggg agaccucuau     1860

cugcacuucu uccaaggccu gagcgguuug aucuggcugg acuuguccca gaaccgccug     1920

cacacccucc ugccccaaac ccugcgcaac cuccccaaga gccuacaggu gcugcgucuc     1980

cgugacaauu accuggccuu cuuuaagugg uggagccucc acuuccugcc caaacuggaa     2040

guccucgacc uggcaggaaa ccagcugaag gcccugacca auggcagccu gccugcuggc     2100

acccggcucc ggaggcugga ugucagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uuuuccaagg ccaaggagcu gcgagagcuc aaccuuagcg ccaacgcccu caagacagug     2220

gaccacuccu gguuugggcc ccuggcgagu gcccugcaaa uacuagaugu aagcgccaac     2280

ccucugcacu gcgccugugg ggcggccuuu auggacuucc ugcuggaggu gcaggcugcc     2340

gugcccgguc ugcccagccg ggugaagugu ggcaguccgg gccagcucca gggccucagc     2400

aucuuugcac aggaccugcg ccucugccug gaugaggccc ucuccuggga cuguuucgcc     2460

cucucgcugc uggcuguggc ucugggccug ggugugccca ugcugcauca ccucuguggc     2520

ugggaccucu gguacugcuu ccaccugugc cuggccuggc uucccuggcg ggggcggcaa     2580

agugggcgag augaggaugc ccugcccuac gaugccuucg uggucuucga caaaacgcag     2640

agcgcagugg cagacugggu guacaacgag cuucgggggc agcuggagga gugccguggg     2700

cgcugggcac uccaccugug ccuggaggaa cgcgacuggc ugccuggcaa aacccucuuu     2760

gagaaccugu gggccucggu cuauggcagc cgcaagacgc uguuugugcu ggcccacacg     2820

gaccggguca guggucucuu gcgcgccagc uuccugcugg cccagcagcg ccugcuggag     2880

gaccgcaagg acgucguggu gcuggugauc cugagcccug acggccgccg cucccgcuac     2940

gugcggcugc gccagcgccu cugccgccag aguguccucc ucuggcccca ccagcccagu     3000

ggucagcgca gcuucugggc ccagcugggc auggcccuga ccagggacaa ccaccacuuc     3060

uauaaccgga acuucugcca gggacccacg gccgaauag                            3099


<210>  9811
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__AAZ95518

<400>  9811
augggcuucu gccgcagcgc ccugcacccc cucucccugc uggugcaggc caucaugcuc       60

gcgaugaccc uggcccuggg gacccucccg gccuuccugc ccugcgagcu gcagccccac      120

ggccucguca acugcaacug gcuguuccug aaguccgugc cccacuucag cauggccgcc      180

ccgcggggga acgugacgag ccucucccug agcuccaacc gcauccacca ccuccacgac      240

agcgacuucg cgcaccuccc cucccugcgg caccugaacc ucaaguggaa cugcccgccc      300

gucggccuga gccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccug      360

gccgugccca cccucgagga gcugaaccug agcuacaaca acaucaugac ggugccggcc      420

cuccccaagu cccugaucag ccugucccuc agccacacca acauccugau gcuggacucc      480

gccagccucg cggggcugca cgcccugcgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccggcaggc ccuggagguc gcccccggcg cccugcucgg gcugggcaac      600

cugacccacc ucucccugaa guacaacaac cugaccgugg ugccgcgcaa ccuccccagc      660

agccuggagu accugcuccu guccuacaac cggaucguca agcuggcgcc cgaggaccuc      720

gccaaccuga cggcccugcg cgugcuggac gucgggggca acugccggcg cugcgaccac      780

gcccccaacc cgugcaugga gugcccccgg cacuuccccc agcuccaccc cgacaccuuc      840

agccaccugu cccgccugga ggggcucgug cugaaggaca gcucccugag cuggcucaac      900

gccuccuggu uccggggccu gggcaaccug cgcgugcucg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggcguuc caggggcuca cgcagcugcg gaagcugaac     1020

cucuccuuca acuaccagaa gcgcgugagc uucgcccacc ugucccuggc cccgagcuuc     1080

ggcucccucg ucgcccugaa ggagcuggac augcacggga ucuucuuccg gagccucgac     1140

gagaccaccc ugcgcccccu ggcccggcuc cccaugcugc agacccugcg ccuccagaug     1200

aacuucauca accaggcgca gcugggcauc uuccgggccu uccccggccu gcgcuacgug     1260

gaccucuccg acaaccgcau cagcggggcc uccgagcuga cggccaccau gggcgaggcc     1320

gacgggggcg agaaggugug gcugcagccg ggggaccucg cgcccgcccc cgucgacacc     1380

ccgagcuccg aggacuuccg gcccaacugc agcacccuga acuucacgcu ggaccucagc     1440

cgcaacaacc uggugaccgu gcagcccgag auguucgccc agcuguccca ccuccagugc     1500

cugcggcuga gccacaacug caucucccag gccgucaacg gcagccaguu ccucccccug     1560

accggccucc aggugcugga ccugucccac aacaagcugg accucuacca cgagcacagc     1620

uucaccgagc ugccgcgccu ggaggcgcuc gaccuguccu acaacagcca gcccuucggg     1680

augcagggcg uggggcacaa cuucuccuuc gucgcccacc uccggacgcu gcgccaccug     1740

agccuggccc acaacaacau ccacucccag gugagccagc agcucugcuc caccagccug     1800

cgggcccugg acuucuccgg caacgcccuc gggcacaugu gggcggaggg cgaccuguac     1860

cugcacuucu uccagggccu cagcgggcug aucuggcugg accucuccca gaaccgccug     1920

cacacccugc ucccccagac ccugcggaac cugcccaaga gccuccaggu ccugcgccug     1980

cgggacaacu accucgccuu cuucaagugg uggagccugc acuuccugcc gaagcucgag     2040

gugcuggacc uggccggcaa ccagcucaag gcccugacga acgggucccu gcccgccggc     2100

acccgccucc ggcgccugga cgugagcugc aacuccauca gcuucgucgc gcccggguuc     2160

uucuccaagg ccaaggagcu gcgggagcuc aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacuccu gguucggccc ccucgccagc gcgcugcaga uccuggacgu guccgccaac     2280

ccgcuccacu gcgccugcgg cgccgcguuc auggacuucc ugcuggaggu ccaggccgcc     2340

gugcccgggc ugcccagccg cgugaagugc ggcucccccg ggcagcucca gggccugagc     2400

aucuucgccc aggaccugcg gcucugccug gacgaggccc uguccuggga cugcuucgcg     2460

cucagccugc uggccgucgc ccucggccug ggggugccga ugcugcacca ccucugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cucgccuggc ugcccuggcg cgggcggcag     2580

uccggccgcg acgaggacgc ccugcccuac gacgcguucg uggucuucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cuccgcgggc agcuggagga gugccggggc     2700

cgcugggccc ugcaccucug ccuggaggag cgggacuggc ugcccggcaa gacgcuguuc     2760

gagaaccugu gggccuccgu cuacgggagc cgcaagaccc uguucgugcu cgcgcacacc     2820

gaccgggugu ccggccugcu gcgcgccagc uuccuccugg cccagcagcg gcugcucgag     2880

gaccgcaagg acgucguggu gcuggucauc cugagcccgg acgggcggcg cucccgguac     2940

gugcgccucc ggcagcgccu gugccggcag agcgugcugc ucuggcccca ccagcccucc     3000

ggccagcgca gcuucugggc ccagcugggg auggcgcuga cccgggacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacg gccgaguga                            3099


<210>  9812
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__AAZ95518

<400>  9812
augggcuucu gccgcuccgc ccuccacccc cucucccucc ucguccaggc caucaugcuc       60

gccaugaccc ucgcccucgg cacccucccc gccuuccucc ccugcgagcu ccagccccac      120

ggccucguca acugcaacug gcucuuccuc aaguccgucc cccacuucuc cauggccgcc      180

ccccgcggca acgucaccuc ccucucccuc uccuccaacc gcauccacca ccuccacgac      240

uccgacuucg cccaccuccc cucccuccgc caccucaacc ucaaguggaa cugccccccc      300

gucggccucu cccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccuc      360

gccgucccca cccucgagga gcucaaccuc uccuacaaca acaucaugac cguccccgcc      420

cuccccaagu cccucaucuc ccucucccuc ucccacacca acauccucau gcucgacucc      480

gccucccucg ccggccucca cgcccuccgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccgccaggc ccucgagguc gcccccggcg cccuccucgg ccucggcaac      600

cucacccacc ucucccucaa guacaacaac cucaccgucg ucccccgcaa ccuccccucc      660

ucccucgagu accuccuccu cuccuacaac cgcaucguca agcucgcccc cgaggaccuc      720

gccaaccuca ccgcccuccg cguccucgac gucggcggca acugccgccg cugcgaccac      780

gcccccaacc ccugcaugga gugcccccgc cacuuccccc agcuccaccc cgacaccuuc      840

ucccaccucu cccgccucga gggccucguc cucaaggacu ccucccucuc cuggcucaac      900

gccuccuggu uccgcggccu cggcaaccuc cgcguccucg accucuccga gaacuuccuc      960

uacaagugca ucaccaagac caaggccuuc cagggccuca cccagcuccg caagcucaac     1020

cucuccuuca acuaccagaa gcgcgucucc uucgcccacc ucucccucgc ccccuccuuc     1080

ggcucccucg ucgcccucaa ggagcucgac augcacggca ucuucuuccg cucccucgac     1140

gagaccaccc uccgcccccu cgcccgccuc cccaugcucc agacccuccg ccuccagaug     1200

aacuucauca accaggccca gcucggcauc uuccgcgccu uccccggccu ccgcuacguc     1260

gaccucuccg acaaccgcau cuccggcgcc uccgagcuca ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggucug gcuccagccc ggcgaccucg cccccgcccc cgucgacacc     1380

cccuccuccg aggacuuccg ccccaacugc uccacccuca acuucacccu cgaccucucc     1440

cgcaacaacc ucgucaccgu ccagcccgag auguucgccc agcucuccca ccuccagugc     1500

cuccgccucu cccacaacug caucucccag gccgucaacg gcucccaguu ccucccccuc     1560

accggccucc agguccucga ccucucccac aacaagcucg accucuacca cgagcacucc     1620

uucaccgagc ucccccgccu cgaggcccuc gaccucuccu acaacuccca gcccuucggc     1680

augcagggcg ucggccacaa cuucuccuuc gucgcccacc uccgcacccu ccgccaccuc     1740

ucccucgccc acaacaacau ccacucccag gucucccagc agcucugcuc caccucccuc     1800

cgcgcccucg acuucuccgg caacgcccuc ggccacaugu gggccgaggg cgaccucuac     1860

cuccacuucu uccagggccu cuccggccuc aucuggcucg accucuccca gaaccgccuc     1920

cacacccucc ucccccagac ccuccgcaac cuccccaagu cccuccaggu ccuccgccuc     1980

cgcgacaacu accucgccuu cuucaagugg uggucccucc acuuccuccc caagcucgag     2040

guccucgacc ucgccggcaa ccagcucaag gcccucacca acggcucccu ccccgccggc     2100

acccgccucc gccgccucga cgucuccugc aacuccaucu ccuucgucgc ccccggcuuc     2160

uucuccaagg ccaaggagcu ccgcgagcuc aaccucuccg ccaacgcccu caagaccguc     2220

gaccacuccu gguucggccc ccucgccucc gcccuccaga uccucgacgu cuccgccaac     2280

ccccuccacu gcgccugcgg cgccgccuuc auggacuucc uccucgaggu ccaggccgcc     2340

guccccggcc uccccucccg cgucaagugc ggcucccccg gccagcucca gggccucucc     2400

aucuucgccc aggaccuccg ccucugccuc gacgaggccc ucuccuggga cugcuucgcc     2460

cucucccucc ucgccgucgc ccucggccuc ggcgucccca ugcuccacca ccucugcggc     2520

ugggaccucu gguacugcuu ccaccucugc cucgccuggc uccccuggcg cggccgccag     2580

uccggccgcg acgaggacgc ccuccccuac gacgccuucg ucgucuucga caagacccag     2640

uccgccgucg ccgacugggu cuacaacgag cuccgcggcc agcucgagga gugccgcggc     2700

cgcugggccc uccaccucug ccucgaggag cgcgacuggc uccccggcaa gacccucuuc     2760

gagaaccucu gggccuccgu cuacggcucc cgcaagaccc ucuucguccu cgcccacacc     2820

gaccgcgucu ccggccuccu ccgcgccucc uuccuccucg cccagcagcg ccuccucgag     2880

gaccgcaagg acgucgucgu ccucgucauc cucucccccg acggccgccg cucccgcuac     2940

guccgccucc gccagcgccu cugccgccag uccguccucc ucuggcccca ccagcccucc     3000

ggccagcgcu ccuucugggc ccagcucggc auggcccuca cccgcgacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacc gccgaguga                            3099


<210>  9813
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__AAZ95518

<400>  9813
augggcuucu gcagaagcgc ccugcacccc cucucccuuc uggugcaggc uaucauguug       60

gcaaugaccu uagcccuggg gacacuaccu gcguuucucc caugugagcu gcaaccgcau      120

ggacuuguca acugcaauug gcuguucuug aagucuguuc cccacuuuuc aauggcugcc      180

ccuaggggua acgugacuag ccucagccug uccucuaauc ggauucauca ccuucaugac      240

ucggauuucg cacaccuccc aucauuacgc caccugaacc uuaaauggaa uugucccccu      300

guaggcuuga gcccaaugca uuuucccugc cacaugacga uagaaccuag uaccuuccug      360

gccgugccaa cacuagagga acucaaccug uccuacaaua acaucaugac ugucccggcu      420

cugcccaagu cucugauuag cuugucccuc ucacauacca auauccugau guuagacagu      480

gcaagccugg ccgggcucca cgcucugcga uuucuguuca uggauggaaa cuguuauuac      540

aaaaauccuu gccgucaggc cuuggaggug gcgccaggcg cacuacuggg ucucgggaac      600

cugacacacc uuucucugaa guauaauaac uugaccguug ugcccagaaa ucucccuucc      660

ucacuggaau acuuacugcu aagcuauaac aggauuguca aacucgcccc agaggaccug      720

gcuaaccuua cugccuugcg ggugcuggau guaggaggca auugucgcag augcgaccau      780

gcacccaacc cguguaugga gugcccuagg cacuuucccc agcuccaucc agauacauuc      840

agucaccugu cucggcuuga aggccugguu uugaaggacu ccagccucuc guggcugaau      900

gcuucuuggu uucgcggguu aggaaaccug cgagugcuag aucucuccga gaauuuccug      960

uacaagugua ucaccaaaac gaaggccuuu cagggucuua cucaauugag aaaacugaac     1020

cucucauuca auuaucagaa gagggucagu uucgcgcauc ugagcuuagc cccuuccuuu     1080

ggcucucugg uggcacuuaa agaauuggac augcacggga uauucuuucg gagccucgau     1140

gagaccacac ugcguccccu agcucgccug ccaaugcucc agacucugag acuucagaug     1200

aacuucauca aucaagccca guugggaauu uuuagggcuu uccccggccu gcgguacgug     1260

gacuuaucag auaaccgaau caguggugcc uccgagcuca ccgcaacaau gggggaagcc     1320

gacggaggcg agaaggucug gcugcagccu ggcgaccuug cuccagcgcc gguugauacc     1380

cccagcucug aagacuuucg cccuaauugc ucaacgcuga acuucacuuu ggaucucagu     1440

agaaauaacc uggugacagu acagccagag auguuugcac aacuaagcca ccuucagugc     1500

cucaggcugu cccauaauug uauuucucag gccgugaacg ggucgcaauu ccuucccuug     1560

accggacugc aggucuuaga ccucagccac aacaagcugg aucuuuacca ugaacacucc     1620

uuuacugagc ugccucggcu agaggcucuc gaccugucau auaauaguca gccauucggu     1680

augcagggcg uggggcacaa cuuuucuuuc guugcccauu ugcgcacacu gagacacuua     1740

agccucgcac auaauaacau ccacucccaa gugucacagc agcugugcag caccucucuu     1800

agggcccugg auuucuccgg aaaugcuuug ggccauaugu gggccgaagg ugaccucuac     1860

cugcacuuuu uccaggggcu aaguggccug auauggcuug aucucagcca aaaccgucug     1920

cacacguugc ugccccagac cuuacggaau cucccgaaau cucugcaggu ccuucgacug     1980

agagacaacu auuuggcauu uuucaagugg uggucccucc auuuucugcc uaaacuagag     2040

gugcuggauc uugcgggaaa ucagcucaag gcucugacaa acggcucauu gccagccggg     2100

acuagguuac gccggcugga cguaaguugu aauagcauuu cguucguugc acccggauuu     2160

uucuccaaag ccaaggaacu cagagagcug aaccuuucug cuaaugcccu gaaaaccgug     2220

gaccacagcu gguuuggucc uuuggcauca gcucuacaaa uccuggaugu cagugccaac     2280

ccccuccauu gcgcgugugg cgccgcuuuc auggacuuuc ugcuugaagu gcaggcagcc     2340

gucccagggu uaccuuccag ggugaagugc ggaucucccg gccagcugca gggucucagc     2400

auuuucgcuc aagauuugcg ccugugucuc gacgaggccc uguccuggga uugcuuugca     2460

cuuucacugu uggcgguugc ccuagggcug ggcgugccaa ugcuccacca uuuaugugga     2520

ugggaccugu gguacugcuu ccaccuuugu cuggcuuggc ucccguggcg aggccggcag     2580

agcgggcgug augaggacgc cuugccuuau gaugcauucg uagucuuuga caagacacag     2640

agugcugugg ccgauugggu uuacaaugaa cugagaggac aacucgagga augcaggggu     2700

cgcugggcac ugcaccuuug ccuagaggaa cgggacuggc ugcccggcaa aacuuuguuc     2760

gagaacuuau gggccucugu guaugggucc agaaagaccc uguuuguccu cgcucauaca     2820

gauaggguga gcggacugcu ucgagcgucg uuccugcucg cccagcagcg cuugcuggag     2880

gaccggaaag acguaguggu ucuagucauc cugucaccag auggcagaag gucucguuac     2940

gugcgccucc ggcagagacu uuguaggcaa agugugcugu uauggcccca ccagccuucc     3000

ggucagcgaa guuuuugggc acaguugggg auggcucuga cccgggacaa ccaucacuuc     3060

uacaaucgca acuuuugcca aggcccaacu gccgaauga                            3099


<210>  9814
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__AAZ95518

<400>  9814
augggcuucu gcagaagcgc ccugcacccc cugagccugc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg cacccugccc gccuuccugc ccugcgagcu gcagccccac      120

ggccugguga acugcaacug gcuguuccug aagagcgugc cccacuucag cauggccgcc      180

cccagaggca acgugaccag ccugagccug agcagcaaca gaauccacca ccugcacgac      240

agcgacuucg cccaccugcc cagccugaga caccugaacc ugaaguggaa cugccccccc      300

gugggccuga gccccaugca cuuccccugc cacaugacca ucgagcccag caccuuccug      360

gccgugccca cccuggagga gcugaaccug agcuacaaca acaucaugac cgugcccgcc      420

cugcccaaga gccugaucag ccugagccug agccacacca acauccugau gcuggacagc      480

gccagccugg ccggccugca cgcccugaga uuccuguuca uggacggcaa cugcuacuac      540

aagaaccccu gcagacaggc ccuggaggug gcccccggcg cccugcuggg ccugggcaac      600

cugacccacc ugagccugaa guacaacaac cugaccgugg ugcccagaaa ccugcccagc      660

agccuggagu accugcugcu gagcuacaac agaaucguga agcuggcccc cgaggaccug      720

gccaaccuga ccgcccugag agugcuggac gugggcggca acugcagaag augcgaccac      780

gcccccaacc ccugcaugga gugccccaga cacuuccccc agcugcaccc cgacaccuuc      840

agccaccuga gcagacugga gggccuggug cugaaggaca gcagccugag cuggcugaac      900

gccagcuggu ucagaggccu gggcaaccug agagugcugg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggccuuc cagggccuga cccagcugag aaagcugaac     1020

cugagcuuca acuaccagaa gagagugagc uucgcccacc ugagccuggc ccccagcuuc     1080

ggcagccugg uggcccugaa ggagcuggac augcacggca ucuucuucag aagccuggac     1140

gagaccaccc ugagaccccu ggccagacug cccaugcugc agacccugag acugcagaug     1200

aacuucauca accaggccca gcugggcauc uucagagccu uccccggccu gagauacgug     1260

gaccugagcg acaacagaau cagcggcgcc agcgagcuga ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggugug gcugcagccc ggcgaccugg cccccgcccc cguggacacc     1380

cccagcagcg aggacuucag acccaacugc agcacccuga acuucacccu ggaccugagc     1440

agaaacaacc uggugaccgu gcagcccgag auguucgccc agcugagcca ccugcagugc     1500

cugagacuga gccacaacug caucagccag gccgugaacg gcagccaguu ccugccccug     1560

accggccugc aggugcugga ccugagccac aacaagcugg accuguacca cgagcacagc     1620

uucaccgagc ugcccagacu ggaggcccug gaccugagcu acaacagcca gcccuucggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcccacc ugagaacccu gagacaccug     1740

agccuggccc acaacaacau ccacagccag gugagccagc agcugugcag caccagccug     1800

agagcccugg acuucagcgg caacgcccug ggccacaugu gggccgaggg cgaccuguac     1860

cugcacuucu uccagggccu gagcggccug aucuggcugg accugagcca gaacagacug     1920

cacacccugc ugccccagac ccugagaaac cugcccaaga gccugcaggu gcugagacug     1980

agagacaacu accuggccuu cuucaagugg uggagccugc acuuccugcc caagcuggag     2040

gugcuggacc uggccggcaa ccagcugaag gcccugacca acggcagccu gcccgccggc     2100

accagacuga gaagacugga cgugagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uucagcaagg ccaaggagcu gagagagcug aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacagcu gguucggccc ccuggccagc gcccugcaga uccuggacgu gagcgccaac     2280

ccccugcacu gcgccugcgg cgccgccuuc auggacuucc ugcuggaggu gcaggccgcc     2340

gugcccggcc ugcccagcag agugaagugc ggcagccccg gccagcugca gggccugagc     2400

aucuucgccc aggaccugag acugugccug gacgaggccc ugagcuggga cugcuucgcc     2460

cugagccugc uggccguggc ccugggccug ggcgugccca ugcugcacca ccugugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cuggccuggc ugcccuggag aggcagacag     2580

agcggcagag acgaggacgc ccugcccuac gacgccuucg ugguguucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cugagaggcc agcuggagga gugcagaggc     2700

agaugggccc ugcaccugug ccuggaggag agagacuggc ugcccggcaa gacccuguuc     2760

gagaaccugu gggccagcgu guacggcagc agaaagaccc uguucgugcu ggcccacacc     2820

gacagaguga gcggccugcu gagagccagc uuccugcugg cccagcagag acugcuggag     2880

gacagaaagg acgugguggu gcuggugauc cugagccccg acggcagaag aagcagauac     2940

gugagacuga gacagagacu gugcagacag agcgugcugc uguggcccca ccagcccagc     3000

ggccagagaa gcuucugggc ccagcugggc auggcccuga ccagagacaa ccaccacuuc     3060

uacaacagaa acuucugcca gggccccacc gccgaguga                            3099


<210>  9815
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__AAZ95518

<400>  9815
augggcuucu gcagaagcgc ccugcacccc cucucccugc uugugcaggc uaucaugcug       60

gccaugaccc ucgcgcuggg gacacuuccu gcuuuucugc cgugugagcu ccaaccccau      120

ggacugguca acugcaauug gcuguuccuc aagucuguuc cucacuuuag cauggccgcu      180

ccccggggca acgugacguc ccugucucuu agcuccaauc gcauucauca ucugcacgac      240

ucugauuucg cucaccuccc uagccugaga caccuuaacc ugaaauggaa uugucccccu      300

guggggcucu ccccgaugca uuuucccugc cacaugacca ucgaaccuag cacauuccug      360

gccgucccca cccuggagga acucaaccug ucuuacaaua acauuaugac agugccugcu      420

cugcccaagu cccugaucag ccucucucug ucccauacca auauucuuau gcuggacagc      480

gccucucucg cgggacugca cgcccugcgg uuucucuuca uggauggcaa cuguuauuac      540

aaaaauccgu gccgccaggc ucuggagguu gccccugggg cccuucuggg acucggcaac      600

cugacacacc uuucccugaa guauaauaac cucaccgugg uccccagaaa ucugccuagc      660

ucccuggaau accuccugcu uucuuauaac cggaucguga aacuggcccc cgaggaccuc      720

gcgaaccuga cggcccugcg cguucuugau gugggcggga auuguagacg gugcgaccau      780

gcucccaacc cuuguaugga gugcccgcgc cacuuucccc agcuccaucc ugauaccuuc      840

agccaccugu ccagacugga aggacucguc cugaaggaca gcucucuuuc cuggcugaau      900

gccagcuggu uucggggccu cgggaaccug cgcgugcugg aucuuucuga gaauuuccuc      960

uacaagugua ucacaaaaac caaggcuuuu cagggacuga cacaacugag aaaacucaac     1020

cugagcuuca auuaucagaa gcgggugucc uucgcccauc uuucucuggc ccccagcuuu     1080

ggcucccucg ucgcucugaa agaacuggac augcacggga uuuucuuucg cagccuugau     1140

gagaccacgc ucagaccucu ggcgcggcug cccaugcucc agacacugag acuucagaug     1200

aacuucauca aucaagccca gcugggaauu uuucgcgcuu ucccgggccu ccgguacguu     1260

gaccugucug auaacagaau cuccggcgcc agcgagcuga ccgccacaau gggggaagcu     1320

gacggaggcg agaaggugug gcuucagccu ggggaccucg cccccgcgcc uguggauacc     1380

cccucuuccg aagacuuucg cccuaauugc agcacccuga acuucacacu ggaucucucc     1440

cggaauaacc uggucacggu gcagcccgag auguuugcuc aacuuucuca ucugcagugc     1500

cucagacuga gccacaauug uauuucccag gccguuaacg gaucucaauu ccugccgcuu     1560

accggccuuc aggugcucga ccugagccac aacaagcucg aucuguacca ugaacacucc     1620

uuuacagagc uuccucgccu ggaggcccuc gaccugagcu auaauucuca gcccuucggg     1680

augcagggag ucggccacaa cuuuuccuuc guggcucauc ugcggacccu uagacaccug     1740

agccucgccc auaauaacau ccacucucaa guuucccagc agcugugcag cacaucucuc     1800

cgcgcucugg auuucagcgg caaugcccuu gggcauaugu gggcggaagg agaccuguac     1860

cuccacuuuu uccagggccu guccgggcug auuuggcuug aucugagcca aaaccggcuc     1920

cacacccugc ucccccagac gcugagaaau cuuccuaaau cucuccaggu gcugcgccug     1980

cgggacaacu aucuggccuu uuucaagugg uggucccuuc auuuucugcc gaaacucgag     2040

guccuggauc ucgcuggaaa ucagcugaag gcccuuacaa acggcagccu gcccgcuggg     2100

accagacugc ggcgccucga cguguccugu aauucuauca gcuucgucgc cccuggcuuu     2160

uucuccaaag cgaaggaacu gagagagcuu aaccugucug ccaaugcucu caaaaccgug     2220

gaccacagcu gguuuggacc ccuggccucc gcucuccaaa uccuggaugu uucugccaac     2280

ccucuucauu gcgccugugg cgcugcguuc auggacuuuc ugcuggaagu gcaggccgcu     2340

guccccgggc ucccuagccg ggugaagugc ggaucccccg gccagcugca ggggcuuagc     2400

auuuucgccc aagaucugag acucugucug gacgaggccc ucucuuggga uugcuuugcu     2460

cugucccuuc uggccguugc gcugggacuc ggcgugccga ugcugcacca ucuuuguggg     2520

ugggaccugu gguacugcuu ccaccucugu cuggcuuggc ugccuuggcg cggccggcag     2580

agcggaagag augaggacgc ccuccccuau gaugccuucg ucguguuuga caagacacag     2640

ucugcugugg ccgauugggu uuacaaugaa cuucgcggcc aacuggagga augcagaggg     2700

cggugggcgc ugcaccucug ccuggaggaa cgcgacuggc uuccuggaaa aacccuguuc     2760

gagaaccucu gggcuuccgu cuauggcagc agaaagacac uguuugugcu ggcccauacg     2820

gaucgggugu cugggcuccu ucgcgccucc uuccugcugg cucagcagag acuccuggag     2880

gaccggaaag acgucguggu ucuugugauc cugagccccg auggacgcag aucccgguac     2940

guccgccuca gacagcggcu guguagacaa agcgugcugc ucuggccgca ccagccuucu     3000

ggccagcgca gcuuuugggc ccagcuuggg auggcucuga cccgggacaa ccaucacuuc     3060

uacaauagaa acuuuugcca aggccccaca gccgaauga                            3099


<210>  9816
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__D1CS62

<400>  9816

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Gln Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln 
        995                 1000                1005            


Leu Gly Met Ala Leu Thr Arg Asp Asn His His Phe Tyr Asn Arg Asn 
    1010                1015                1020                


Phe Cys Gln Gly Pro Thr Ala Glu 
1025                1030        


<210>  9817
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__AAZ95519

<400>  9817
auggguuucu gccgcagcgc ccugcacccg cugucucucc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg uaccuugccu gccuuccuac ccugugagcu ccagccccac      120

ggccugguga acugcaacug gcuguuccug aagucugugc cccacuucuc cauggcagca      180

ccccguggca augucaccag ccuuuccuug uccuccaacc gcauccacca ccuccaugau      240

ucugacuuug cccaccugcc cagccugcgg caucucaacc ucaaguggaa cugcccgccg      300

guuggccuca gccccaugca cuuccccugc cacaugacca ucgagcccag caccuucuug      360

gcugugccca cccuggaaga gcuaaaccug agcuacaaca acaucaugac ugugccugcg      420

cugcccaaau cccucauauc ccugucccuc agccauacca acauccugau gcuagacucu      480

gccagccucg ccggccugca ugcccugcgc uuccuauuca uggacggcaa cuguuauuac      540

aagaaccccu gcaggcaggc acuggaggug gccccgggug cccuccuugg ccugggcaac      600

cucacccacc ugucacucaa guacaacaac cucacugugg ugccccgcaa ccugccuucc      660

agccuggagu aucugcuguu guccuacaac cgcaucguca aacuggcgcc ugaggaccug      720

gccaaucuga ccgcccugcg ugugcucgau gugggcggaa auugccgccg cugcgaccac      780

gcucccaacc ccugcaugga gugcccucgu cacuuccccc agcuacaucc cgauaccuuc      840

agccaccuga gccgucuuga aggccuggug uugaaggaca guucucucuc cuggcugaau      900

gccaguuggu uccgugggcu gggaaaccuc caagugcugg accugaguga gaacuuccuc      960

uacaaaugca ucacuaaaac caaggccuuc cagggccuaa cacagcugcg caagcuuaac     1020

cuguccuuca auuaccaaaa gagggugucc uuugcccacc ugucucuggc cccuuccuuc     1080

gggagccugg ucgcccugaa ggagcuggac augcacggca ucuucuuccg cucacucgau     1140

gagaccacgc uccggccacu ggcccgccug cccaugcucc agacucugcg ucugcagaug     1200

aacuucauca accaggccca gcucggcauc uucagggccu ucccuggccu gcgcuacgug     1260

gaccugucgg acaaccgcau cagcggagcu ucggagcuga cagccaccau gggggaggca     1320

gauggagggg agaaggucug gcugcagccu ggggaccuug cuccggcccc aguggacacu     1380

cccagcucug aagacuucag gcccaacugc agcacccuca acuucaccuu ggaucuguca     1440

cggaacaacc uggugaccgu gcagccggag auguuugccc agcucucgca ccugcagugc     1500

cugcgccuga gccacaacug caucucgcag gcagucaaug gcucccaguu ccugccgcug     1560

accggucugc aggugcuaga ccugucccac aauaagcugg accucuacca cgagcacuca     1620

uucacggagc uaccacgacu ggaggcccug gaccucagcu acaacagcca gcccuuuggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcucacc ugcgcacccu gcgccaccuc     1740

agccuggccc acaacaacau ccacagccaa gugucccagc agcucugcag uacgucgcug     1800

cgggcccugg acuucagcgg caaugcacug ggccauaugu gggccgaggg agaccucuau     1860

cugcacuucu uccaaggccu gagcgguuug aucuggcugg acuuguccca gaaccgccug     1920

cacacccucc ugccccaaac ccugcgcaac cuccccaaga gccuacaggu gcugcgucuc     1980

cgugacaauu accuggccuu cuuuaagugg uggagccucc acuuccugcc caaacuggaa     2040

guccucgacc uggcaggaaa ccagcugaag gcccugacca auggcagccu gccugcuggc     2100

acccggcucc ggaggcugga ugucagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uuuuccaagg ccaaggagcu gcgagagcuc aaccuuagcg ccaacgcccu caagacagug     2220

gaccacuccu gguuugggcc ccuggcgagu gcccugcaaa uacuagaugu aagcgccaac     2280

ccucugcacu gcgccugugg ggcggccuuu auggacuucc ugcuggaggu gcaggcugcc     2340

gugcccgguc ugcccagccg ggugaagugu ggcaguccgg gccagcucca gggccucagc     2400

aucuuugcac aggaccugcg ccucugccug gaugaggccc ucuccuggga cuguuucgcc     2460

cucucgcugc uggcuguggc ucugggccug ggugugccca ugcugcauca ccucuguggc     2520

ugggaccucu gguacugcuu ccaccugugc cuggccuggc uucccuggcg ggggcggcaa     2580

agugggcgag augaggaugc ccugcccuac gaugccuucg uggucuucga caaaacgcag     2640

agcgcagugg cagacugggu guacaacgag cuucgggggc agcuggagga gugccguggg     2700

cgcugggcac uccgccugug ccuggaggaa cgcgacuggc ugccuggcaa aacccucuuu     2760

gagaaccugu gggccucggu cuauggcagc cgcaagacgc uguuugugcu ggcccacacg     2820

gaccggguca guggucucuu gcgcgccagc uuccugcugg cccagcagcg ccugcuggag     2880

gaccgcaagg acgucguggu gcuggugauc cugagcccug acggccgccg cucccgcuac     2940

gugcggcugc gccagcgccu cugccgccag aguguccucc ucuggcccca ccagcccagu     3000

ggucagcgca gcuucugggc ccagcugggc auggcccuga ccagggacaa ccaccacuuc     3060

uauaaccgga acuucugcca gggacccacg gccgaauag                            3099


<210>  9818
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__AAZ95519

<400>  9818
augggcuucu gccgcagcgc ccugcacccc cucucccugc uggugcaggc caucaugcuc       60

gcgaugaccc uggcccuggg gacccucccg gccuuccugc ccugcgagcu gcagccccac      120

ggccucguca acugcaacug gcuguuccug aaguccgugc cccacuucag cauggccgcc      180

ccgcggggga acgugacgag ccucucccug agcuccaacc gcauccacca ccuccacgac      240

agcgacuucg cgcaccuccc cucccugcgg caccugaacc ucaaguggaa cugcccgccc      300

gucggccuga gccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccug      360

gccgugccca cccucgagga gcugaaccug agcuacaaca acaucaugac ggugccggcc      420

cuccccaagu cccugaucag ccugucccuc agccacacca acauccugau gcuggacucc      480

gccagccucg cggggcugca cgcccugcgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccggcaggc ccuggagguc gcccccggcg cccugcucgg gcugggcaac      600

cugacccacc ucucccugaa guacaacaac cugaccgugg ugccgcgcaa ccuccccagc      660

agccuggagu accugcuccu guccuacaac cggaucguca agcuggcgcc cgaggaccuc      720

gccaaccuga cggcccugcg cgugcuggac gucgggggca acugccggcg cugcgaccac      780

gcccccaacc cgugcaugga gugcccccgg cacuuccccc agcuccaccc cgacaccuuc      840

agccaccugu cccgccugga ggggcucgug cugaaggaca gcucccugag cuggcucaac      900

gccuccuggu uccggggccu gggcaaccuc caggugcugg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggcguuc caggggcuca cgcagcugcg caagcugaac     1020

cucuccuuca acuaccagaa gcgggugagc uucgcccacc ugucccuggc cccgagcuuc     1080

ggcucccucg ucgcccugaa ggagcuggac augcacggga ucuucuuccg cagccucgac     1140

gagaccaccc ugcggccccu ggcccgccuc cccaugcugc agacccugcg gcuccagaug     1200

aacuucauca accaggcgca gcugggcauc uuccgcgccu uccccggccu gcgguacgug     1260

gaccucuccg acaaccgcau cagcggggcc uccgagcuga cggccaccau gggcgaggcc     1320

gacgggggcg agaaggugug gcugcagccg ggggaccucg cgcccgcccc cgucgacacc     1380

ccgagcuccg aggacuuccg ccccaacugc agcacccuga acuucacgcu ggaccucagc     1440

cggaacaacc uggugaccgu gcagcccgag auguucgccc agcuguccca ccuccagugc     1500

cugcgccuga gccacaacug caucucccag gccgucaacg gcagccaguu ccucccccug     1560

accggccucc aggugcugga ccugucccac aacaagcugg accucuacca cgagcacagc     1620

uucaccgagc ugccgcggcu ggaggcgcuc gaccuguccu acaacagcca gcccuucggg     1680

augcagggcg uggggcacaa cuucuccuuc gucgcccacc uccgcacgcu gcggcaccug     1740

agccuggccc acaacaacau ccacucccag gugagccagc agcucugcuc caccagccug     1800

cgcgcccugg acuucuccgg caacgcccuc gggcacaugu gggcggaggg cgaccuguac     1860

cugcacuucu uccagggccu cagcgggcug aucuggcugg accucuccca gaaccggcug     1920

cacacccugc ucccccagac ccugcgcaac cugcccaaga gccuccaggu ccugcggcug     1980

cgcgacaacu accucgccuu cuucaagugg uggagccugc acuuccugcc gaagcucgag     2040

gugcuggacc uggccggcaa ccagcucaag gcccugacga acgggucccu gcccgccggc     2100

acccggcucc gccggcugga cgugagcugc aacuccauca gcuucgucgc gcccggguuc     2160

uucuccaagg ccaaggagcu gcgcgagcuc aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacuccu gguucggccc ccucgccagc gcgcugcaga uccuggacgu guccgccaac     2280

ccgcuccacu gcgccugcgg cgccgcguuc auggacuucc ugcuggaggu ccaggccgcc     2340

gugcccgggc ugcccagccg ggugaagugc ggcucccccg ggcagcucca gggccugagc     2400

aucuucgccc aggaccugcg ccucugccug gacgaggccc uguccuggga cugcuucgcg     2460

cucagccugc uggccgucgc ccucggccug ggggugccga ugcugcacca ccucugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cucgccuggc ugcccuggcg ggggcgccag     2580

uccggccggg acgaggacgc ccugcccuac gacgcguucg uggucuucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cuccgcgggc agcuggagga gugccgcggc     2700

cggugggccc ugcgccucug ccuggaggag cgggacuggc ugcccggcaa gacgcuguuc     2760

gagaaccugu gggccuccgu cuacgggagc cgcaagaccc uguucgugcu cgcgcacacc     2820

gaccgggugu ccggccugcu gcgcgccagc uuccuccugg cccagcagcg gcugcucgag     2880

gaccgcaagg acgucguggu gcuggucauc cugagcccgg acgggcggcg cucccgguac     2940

gugcgccucc ggcagcgccu gugccggcag agcgugcugc ucuggcccca ccagcccucc     3000

ggccagcgca gcuucugggc ccagcugggg auggcgcuga cccgggacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacg gccgaguga                            3099


<210>  9819
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__AAZ95519

<400>  9819
augggcuucu gccgcuccgc ccuccacccc cucucccucc ucguccaggc caucaugcuc       60

gccaugaccc ucgcccucgg cacccucccc gccuuccucc ccugcgagcu ccagccccac      120

ggccucguca acugcaacug gcucuuccuc aaguccgucc cccacuucuc cauggccgcc      180

ccccgcggca acgucaccuc ccucucccuc uccuccaacc gcauccacca ccuccacgac      240

uccgacuucg cccaccuccc cucccuccgc caccucaacc ucaaguggaa cugccccccc      300

gucggccucu cccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccuc      360

gccgucccca cccucgagga gcucaaccuc uccuacaaca acaucaugac cguccccgcc      420

cuccccaagu cccucaucuc ccucucccuc ucccacacca acauccucau gcucgacucc      480

gccucccucg ccggccucca cgcccuccgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccgccaggc ccucgagguc gcccccggcg cccuccucgg ccucggcaac      600

cucacccacc ucucccucaa guacaacaac cucaccgucg ucccccgcaa ccuccccucc      660

ucccucgagu accuccuccu cuccuacaac cgcaucguca agcucgcccc cgaggaccuc      720

gccaaccuca ccgcccuccg cguccucgac gucggcggca acugccgccg cugcgaccac      780

gcccccaacc ccugcaugga gugcccccgc cacuuccccc agcuccaccc cgacaccuuc      840

ucccaccucu cccgccucga gggccucguc cucaaggacu ccucccucuc cuggcucaac      900

gccuccuggu uccgcggccu cggcaaccuc cagguccucg accucuccga gaacuuccuc      960

uacaagugca ucaccaagac caaggccuuc cagggccuca cccagcuccg caagcucaac     1020

cucuccuuca acuaccagaa gcgcgucucc uucgcccacc ucucccucgc ccccuccuuc     1080

ggcucccucg ucgcccucaa ggagcucgac augcacggca ucuucuuccg cucccucgac     1140

gagaccaccc uccgcccccu cgcccgccuc cccaugcucc agacccuccg ccuccagaug     1200

aacuucauca accaggccca gcucggcauc uuccgcgccu uccccggccu ccgcuacguc     1260

gaccucuccg acaaccgcau cuccggcgcc uccgagcuca ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggucug gcuccagccc ggcgaccucg cccccgcccc cgucgacacc     1380

cccuccuccg aggacuuccg ccccaacugc uccacccuca acuucacccu cgaccucucc     1440

cgcaacaacc ucgucaccgu ccagcccgag auguucgccc agcucuccca ccuccagugc     1500

cuccgccucu cccacaacug caucucccag gccgucaacg gcucccaguu ccucccccuc     1560

accggccucc agguccucga ccucucccac aacaagcucg accucuacca cgagcacucc     1620

uucaccgagc ucccccgccu cgaggcccuc gaccucuccu acaacuccca gcccuucggc     1680

augcagggcg ucggccacaa cuucuccuuc gucgcccacc uccgcacccu ccgccaccuc     1740

ucccucgccc acaacaacau ccacucccag gucucccagc agcucugcuc caccucccuc     1800

cgcgcccucg acuucuccgg caacgcccuc ggccacaugu gggccgaggg cgaccucuac     1860

cuccacuucu uccagggccu cuccggccuc aucuggcucg accucuccca gaaccgccuc     1920

cacacccucc ucccccagac ccuccgcaac cuccccaagu cccuccaggu ccuccgccuc     1980

cgcgacaacu accucgccuu cuucaagugg uggucccucc acuuccuccc caagcucgag     2040

guccucgacc ucgccggcaa ccagcucaag gcccucacca acggcucccu ccccgccggc     2100

acccgccucc gccgccucga cgucuccugc aacuccaucu ccuucgucgc ccccggcuuc     2160

uucuccaagg ccaaggagcu ccgcgagcuc aaccucuccg ccaacgcccu caagaccguc     2220

gaccacuccu gguucggccc ccucgccucc gcccuccaga uccucgacgu cuccgccaac     2280

ccccuccacu gcgccugcgg cgccgccuuc auggacuucc uccucgaggu ccaggccgcc     2340

guccccggcc uccccucccg cgucaagugc ggcucccccg gccagcucca gggccucucc     2400

aucuucgccc aggaccuccg ccucugccuc gacgaggccc ucuccuggga cugcuucgcc     2460

cucucccucc ucgccgucgc ccucggccuc ggcgucccca ugcuccacca ccucugcggc     2520

ugggaccucu gguacugcuu ccaccucugc cucgccuggc uccccuggcg cggccgccag     2580

uccggccgcg acgaggacgc ccuccccuac gacgccuucg ucgucuucga caagacccag     2640

uccgccgucg ccgacugggu cuacaacgag cuccgcggcc agcucgagga gugccgcggc     2700

cgcugggccc uccgccucug ccucgaggag cgcgacuggc uccccggcaa gacccucuuc     2760

gagaaccucu gggccuccgu cuacggcucc cgcaagaccc ucuucguccu cgcccacacc     2820

gaccgcgucu ccggccuccu ccgcgccucc uuccuccucg cccagcagcg ccuccucgag     2880

gaccgcaagg acgucgucgu ccucgucauc cucucccccg acggccgccg cucccgcuac     2940

guccgccucc gccagcgccu cugccgccag uccguccucc ucuggcccca ccagcccucc     3000

ggccagcgcu ccuucugggc ccagcucggc auggcccuca cccgcgacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacc gccgaguga                            3099


<210>  9820
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__AAZ95519

<400>  9820
augggcuucu gcagaagcgc ccugcacccc cucucccuuc uggugcaggc uaucauguug       60

gcaaugaccu uagcccuggg gacacuaccu gcguuucucc caugugagcu gcaaccgcau      120

ggacuuguca acugcaauug gcuguucuug aagucuguuc cccacuuuuc aauggcugcc      180

ccuaggggua acgugacuag ccucagccug uccucuaauc ggauucauca ccuucaugac      240

ucggauuucg cacaccuccc aucauuacgc caccugaacc uuaaauggaa uugucccccu      300

guaggcuuga gcccaaugca uuuucccugc cacaugacga uagaaccuag uaccuuccug      360

gccgugccaa cacuagagga acucaaccug uccuacaaua acaucaugac ugucccggcu      420

cugcccaagu cucugauuag cuugucccuc ucacauacca auauccugau guuagacagu      480

gcaagccugg ccgggcucca cgcucugcga uuucuguuca uggauggaaa cuguuauuac      540

aaaaauccuu gccgucaggc cuuggaggug gcgccaggcg cacuacuggg ucucgggaac      600

cugacacacc uuucucugaa guauaauaac uugaccguug ugcccagaaa ucucccuucc      660

ucacuggaau acuuacugcu aagcuauaac aggauuguca aacucgcccc agaggaccug      720

gcuaaccuua cugccuugcg ggugcuggau guaggaggca auugucgcag augcgaccau      780

gcacccaacc cguguaugga gugcccuagg cacuuucccc agcuccaucc agauacauuc      840

agucaccugu cucggcuuga aggccugguu uugaaggacu ccagccucuc guggcugaau      900

gcuucuuggu uucgcggguu aggaaaccuu caggugcuag aucucuccga gaauuuccug      960

uacaagugua ucaccaaaac gaaggccuuu caaggucuua cucaguugcg aaaacugaac     1020

cucucauuca auuaucagaa gagagucagu uucgcgcauc ugagcuuagc cccuuccuuu     1080

ggcucucugg uggcacuuaa agaauuggac augcacggga uauucuuuag gagccucgau     1140

gagaccacac ugcggccccu agcucgucug ccaaugcucc agacucugcg ccuucaaaug     1200

aacuucauca aucaggccca guugggaauu uuuagagcuu uccccggccu gagguacgug     1260

gacuuaucag auaaccggau caguggugcc uccgagcuca ccgcaacaau gggggaagcc     1320

gacggaggcg agaaggucug gcugcagccu ggcgaccuug cuccagcgcc gguugauacc     1380

cccagcucug aagacuuucg accuaauugc ucaacgcuga acuucacuuu ggaucucagu     1440

cgcaauaacc uggugacagu acaaccagag auguuugcac agcuaagcca ucugcagugc     1500

cucagacugu cccacaauug uauuucucaa gccgugaacg ggucgcaguu ccuucccuug     1560

accggacugc aggucuuaga ccucagccac aacaagcugg aucuuuacca ugaacacucc     1620

uuuacugagc ugccuaggcu agaggcucuc gaccugucau auaauaguca gccauucggu     1680

augcaaggcg uggggcacaa cuuuucuuuc guugcccauu ugcggacacu gcgccacuua     1740

agccucgcac auaauaacau ccacucccag gugucacagc agcugugcag caccucucuu     1800

agagcccugg auuucuccgg aaaugcuuug ggccauaugu gggccgaagg ugaccucuac     1860

cugcacuuuu uccaagggcu aaguggccug auauggcuug aucucagcca gaacaggcug     1920

cacacguugc ugccccagac cuuacguaau cucccgaaau cucugcaggu ccuucggcug     1980

cgagacaacu auuuggcauu uuucaagugg uggucccucc auuuucugcc uaaacuagag     2040

gugcuggauc uugcgggaaa ucaacucaag gcucugacaa acggcucauu gccagccggg     2100

acuagauuaa ggcgccugga cguaaguugu aauagcauuu cguucguugc acccggauuu     2160

uucuccaaag ccaaggaacu ccgggagcug aaccuuucug cuaaugcccu gaaaaccgug     2220

gaccacagcu gguuuggucc uuuggcauca gcucuacaga uccuggaugu cagugccaac     2280

ccccuccauu gcgcgugugg cgccgcuuuc auggacuuuc ugcuugaagu gcaggcagcc     2340

gucccagggu uaccuuccag agugaagugc ggaucucccg gccagcugca aggucucagc     2400

auuuucgcuc aggauuugag gcugugucuc gacgaggccc uguccuggga uugcuuugca     2460

cuuucacugu uggcgguugc ccuagggcug ggcgugccaa ugcuccacca uuuaugugga     2520

ugggaccugu gguacugcuu ccaccuuugu cuggcuuggc ucccguggcg cggccgacag     2580

agcgggcggg augaggacgc cuugccuuau gaugcauucg uagucuuuga caagacacaa     2640

agugcugugg ccgauugggu uuacaaugaa cugcguggac agcucgagga augcagaggu     2700

aggugggcac ugcgccuuug ccuagaggaa cgggacuggc ugcccggcaa aacuuuguuc     2760

gagaacuuau gggccucugu guaugggucc agaaagaccc uguuuguccu cgcucacaca     2820

gauaggguga gcggacugcu ucgagcgucg uuccugcucg cccagcagcg cuugcuggag     2880

gaccggaaag acguaguggu ucuagucauc cugucaccag auggcagaag gucucguuac     2940

gugcgccucc ggcaaagacu uuguaggcag agugugcugu uauggcccca ucagccuucc     3000

ggucagcgaa guuuuugggc acaauugggg auggcucuga cccgggacaa ccaccauuuc     3060

uacaaucgca acuuuugcca gggcccaacu gccgaauga                            3099


<210>  9821
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__AAZ95519

<400>  9821
augggcuucu gcagaagcgc ccugcacccc cugagccugc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg cacccugccc gccuuccugc ccugcgagcu gcagccccac      120

ggccugguga acugcaacug gcuguuccug aagagcgugc cccacuucag cauggccgcc      180

cccagaggca acgugaccag ccugagccug agcagcaaca gaauccacca ccugcacgac      240

agcgacuucg cccaccugcc cagccugaga caccugaacc ugaaguggaa cugccccccc      300

gugggccuga gccccaugca cuuccccugc cacaugacca ucgagcccag caccuuccug      360

gccgugccca cccuggagga gcugaaccug agcuacaaca acaucaugac cgugcccgcc      420

cugcccaaga gccugaucag ccugagccug agccacacca acauccugau gcuggacagc      480

gccagccugg ccggccugca cgcccugaga uuccuguuca uggacggcaa cugcuacuac      540

aagaaccccu gcagacaggc ccuggaggug gcccccggcg cccugcuggg ccugggcaac      600

cugacccacc ugagccugaa guacaacaac cugaccgugg ugcccagaaa ccugcccagc      660

agccuggagu accugcugcu gagcuacaac agaaucguga agcuggcccc cgaggaccug      720

gccaaccuga ccgcccugag agugcuggac gugggcggca acugcagaag augcgaccac      780

gcccccaacc ccugcaugga gugccccaga cacuuccccc agcugcaccc cgacaccuuc      840

agccaccuga gcagacugga gggccuggug cugaaggaca gcagccugag cuggcugaac      900

gccagcuggu ucagaggccu gggcaaccug caggugcugg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggccuuc cagggccuga cccagcugag aaagcugaac     1020

cugagcuuca acuaccagaa gagagugagc uucgcccacc ugagccuggc ccccagcuuc     1080

ggcagccugg uggcccugaa ggagcuggac augcacggca ucuucuucag aagccuggac     1140

gagaccaccc ugagaccccu ggccagacug cccaugcugc agacccugag acugcagaug     1200

aacuucauca accaggccca gcugggcauc uucagagccu uccccggccu gagauacgug     1260

gaccugagcg acaacagaau cagcggcgcc agcgagcuga ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggugug gcugcagccc ggcgaccugg cccccgcccc cguggacacc     1380

cccagcagcg aggacuucag acccaacugc agcacccuga acuucacccu ggaccugagc     1440

agaaacaacc uggugaccgu gcagcccgag auguucgccc agcugagcca ccugcagugc     1500

cugagacuga gccacaacug caucagccag gccgugaacg gcagccaguu ccugccccug     1560

accggccugc aggugcugga ccugagccac aacaagcugg accuguacca cgagcacagc     1620

uucaccgagc ugcccagacu ggaggcccug gaccugagcu acaacagcca gcccuucggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcccacc ugagaacccu gagacaccug     1740

agccuggccc acaacaacau ccacagccag gugagccagc agcugugcag caccagccug     1800

agagcccugg acuucagcgg caacgcccug ggccacaugu gggccgaggg cgaccuguac     1860

cugcacuucu uccagggccu gagcggccug aucuggcugg accugagcca gaacagacug     1920

cacacccugc ugccccagac ccugagaaac cugcccaaga gccugcaggu gcugagacug     1980

agagacaacu accuggccuu cuucaagugg uggagccugc acuuccugcc caagcuggag     2040

gugcuggacc uggccggcaa ccagcugaag gcccugacca acggcagccu gcccgccggc     2100

accagacuga gaagacugga cgugagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uucagcaagg ccaaggagcu gagagagcug aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacagcu gguucggccc ccuggccagc gcccugcaga uccuggacgu gagcgccaac     2280

ccccugcacu gcgccugcgg cgccgccuuc auggacuucc ugcuggaggu gcaggccgcc     2340

gugcccggcc ugcccagcag agugaagugc ggcagccccg gccagcugca gggccugagc     2400

aucuucgccc aggaccugag acugugccug gacgaggccc ugagcuggga cugcuucgcc     2460

cugagccugc uggccguggc ccugggccug ggcgugccca ugcugcacca ccugugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cuggccuggc ugcccuggag aggcagacag     2580

agcggcagag acgaggacgc ccugcccuac gacgccuucg ugguguucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cugagaggcc agcuggagga gugcagaggc     2700

agaugggccc ugagacugug ccuggaggag agagacuggc ugcccggcaa gacccuguuc     2760

gagaaccugu gggccagcgu guacggcagc agaaagaccc uguucgugcu ggcccacacc     2820

gacagaguga gcggccugcu gagagccagc uuccugcugg cccagcagag acugcuggag     2880

gacagaaagg acgugguggu gcuggugauc cugagccccg acggcagaag aagcagauac     2940

gugagacuga gacagagacu gugcagacag agcgugcugc uguggcccca ccagcccagc     3000

ggccagagaa gcuucugggc ccagcugggc auggcccuga ccagagacaa ccaccacuuc     3060

uacaacagaa acuucugcca gggccccacc gccgaguga                            3099


<210>  9822
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__AAZ95519

<400>  9822
augggcuucu gcagaagcgc ccugcacccc cucucccugc uugugcaggc uaucaugcug       60

gccaugaccc ucgcgcuggg gacacuuccu gcuuuucugc cgugugagcu ccaaccccau      120

ggacugguca acugcaauug gcuguuccuc aagucuguuc cucacuuuag cauggccgcu      180

ccccggggca acgugacguc ccugucucuu agcuccaauc gcauucauca ucugcacgac      240

ucugauuucg cucaccuccc uagccugaga caccuuaacc ugaaauggaa uugucccccu      300

guggggcucu ccccgaugca uuuucccugc cacaugacca ucgaaccuag cacauuccug      360

gccgucccca cccuggagga acucaaccug ucuuacaaua acauuaugac agugccugcu      420

cugcccaagu cccugaucag ccucucucug ucccauacca auauucuuau gcuggacagc      480

gccucucucg cgggacugca cgcccugcgg uuucucuuca uggauggcaa cuguuauuac      540

aaaaauccgu gccgccaggc ucuggagguu gccccugggg cccuucuggg acucggcaac      600

cugacacacc uuucccugaa guauaauaac cucaccgugg uccccagaaa ucugccuagc      660

ucccuggaau accuccugcu uucuuauaac cggaucguga aacuggcccc cgaggaccuc      720

gcgaaccuga cggcccugcg cguucuugau gugggcggga auuguagacg gugcgaccau      780

gcucccaacc cuuguaugga gugcccgcgc cacuuucccc agcuccaucc ugauaccuuc      840

agccaccugu ccagacugga aggacucguc cugaaggaca gcucucuuuc cuggcugaau      900

gccagcuggu uucggggccu cgggaaccuu caggugcugg aucuuucuga gaauuuccuc      960

uacaagugua ucacaaaaac caaggcuuuu caaggacuga cacagcugcg caaacucaac     1020

cugagcuuca auuaucagaa gagagugucc uucgcccauc uuucucuggc ccccagcuuu     1080

ggcucccucg ucgcucugaa agaacuggac augcacggga uuuucuuucg gagccuugau     1140

gagaccacgc uccgcccucu ggcgagacug cccaugcucc agacacugcg gcuucaaaug     1200

aacuucauca aucaggccca gcugggaauu uuuagagcuu ucccgggccu ccgcuacguu     1260

gaccugucug auaaccggau cuccggcgcc agcgagcuga ccgccacaau gggggaagcu     1320

gacggaggcg agaaggugug gcuucagccu ggggaccucg cccccgcgcc uguggauacc     1380

cccucuuccg aagacuuuag accuaauugc agcacccuga acuucacacu ggaucucucc     1440

cgcaauaacc uggucacggu gcaacccgag auguuugcuc agcuuucuca ucugcagugc     1500

cuccggcuga gccacaauug uauuucccaa gccguuaacg gaucucaguu ccugccgcuu     1560

accggccucc aggugcugga ccugagccac aacaagcucg aucuguacca ugaacacucc     1620

uuuacagagc uuccuagacu ggaggcccuc gaccugagcu auaauucuca gcccuucggg     1680

augcaaggag ucggccacaa cuuuuccuuc guggcucauc ugcgcacccu ucggcaccug     1740

agccucgccc auaauaacau ccacucucag guuucccagc agcugugcag cacaucucuc     1800

agagcucugg auuucagcgg caaugcccuu gggcauaugu gggcggaagg agaccuguac     1860

cuccacuuuu uccaaggccu guccgggcug auuuggcuug aucugagcca gaaccgccuc     1920

cacacccugc ucccccagac gcugcggaau cuuccuaaau cucuccaggu gcugagacug     1980

cgcgacaacu aucuggccuu uuucaagugg uggucccuuc auuuucugcc gaaacucgag     2040

guccuggauc ucgcuggaaa ucaacugaag gcccuuacaa acggcagccu gcccgcuggg     2100

acccggcuga gacggcucga cguguccugu aauucuauca gcuucgucgc cccuggcuuu     2160

uucuccaaag cgaaggaacu gcgcgagcuu aaccugucug ccaaugcucu caaaaccgug     2220

gaccacagcu gguuuggacc ccuggccucc gcucuccaga uccuggaugu uucugccaac     2280

ccucuucauu gcgccugugg cgcugcguuc auggacuuuc ugcuggaagu gcaggccgcu     2340

guccccgggc ucccuagcag agugaagugc ggaucccccg gccagcugca agggcuuagc     2400

auuuucgccc aggaucugcg gcucugucug gacgaggccc ucucuuggga uugcuuugcu     2460

cugucccuuc uggccguugc gcugggacuc ggcgugccga ugcugcacca ucuuuguggg     2520

ugggaccugu gguacugcuu ccaccucugu cuggcuuggc ugccuuggag aggccgccag     2580

agcggacggg augaggacgc ccuccccuau gaugccuucg ucguguuuga caagacacaa     2640

ucugcugugg ccgauugggu uuacaaugaa cuuagaggcc agcuggagga augccgcggg     2700

agaugggcgc ugcggcucug ccuggaggaa cgcgacuggc uuccuggaaa aacccuguuc     2760

gagaaccucu gggcuuccgu cuauggcagc agaaagacac uguuugugcu ggcccacacg     2820

gaucgggugu cugggcuccu ucgcgccucc uuccugcugg cucagcagag acuccuggag     2880

gaccggaaag acgucguggu ucuugugauc cugagccccg auggacgcag aucccgguac     2940

guccgccuca gacaacggcu guguagacag agcgugcugc ucuggccgca ucagccuucu     3000

ggccagcgca gcuuuugggc ccaacuuggg auggcucuga cccgggacaa ccaccauuuc     3060

uacaauagaa acuuuugcca gggccccaca gccgaauga                            3099


<210>  9823
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__L0R5D6

<400>  9823

Met Arg Pro Cys Arg Thr Leu Glu Met Val Pro Thr Arg Ala Glu Lys 
1               5                   10                  15      


Asp Lys Ser Ala Ala Ala Val Leu Arg Ala Pro Ala Val Val Gln Glu 
            20                  25                  30          


Pro Arg Pro Glu Gly Gly Ser Val Leu Leu Glu Trp Gly Val Pro Ser 
        35                  40                  45              


Lys Val Tyr Pro Leu Leu Val Leu Ser Arg Ile Pro Ile Ser Pro Cys 
    50                  55                  60                  


Ser Leu Pro Glu Leu Trp Ala Leu Ala Pro Pro Trp Ala Trp 
65                  70                  75              


<210>  9824
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__CCO13834

<400>  9824
augaggcccu gcagaacucu ggagauggug ccuacaaggg cagaaaagga caagucggca       60

gccgcugucc ugagggcacc agcuguggug caggagccaa gaccugaggg uggaaguguc      120

cucuuagaau ggggagugcc cagcaaggug uacccgcuac uggugcuauc cagaauuccc      180

aucucucccu gcucucugcc ugagcucugg gccuuagcuc cucccugggc uugguag         237


<210>  9825
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__CCO13834

<400>  9825
augcgccccu gccggacccu ggagauggug cccacccgcg ccgagaagga caagagcgcc       60

gcggccgucc uccgggcccc cgccguggug caggagcccc gccccgaggg cggguccguc      120

cugcuggagu ggggcgugcc gagcaaggug uacccccucc ugguccuguc ccggaucccc      180

aucagccccu gcucccuccc ggagcugugg gcccuggcgc cgcccugggc cugguga         237


<210>  9826
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__CCO13834

<400>  9826
augcgccccu gccgcacccu cgagaugguc cccacccgcg ccgagaagga caaguccgcc       60

gccgccgucc uccgcgcccc cgccgucguc caggagcccc gccccgaggg cggcuccguc      120

cuccucgagu ggggcguccc cuccaagguc uacccccucc ucguccucuc ccgcaucccc      180

aucucccccu gcucccuccc cgagcucugg gcccucgccc cccccugggc cugguga         237


<210>  9827
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__CCO13834

<400>  9827
augagacccu gcaggacccu ggagauggug ccuacacggg ccgaaaagga caaaagcgcu       60

gcagccgucc uccgcgcgcc agcuguugug caggagccgc gacccgaagg cggguccgua      120

cuucuggagu ggggagugcc uucuaagguc uacccauugu uagugcuguc acguaucccc      180

auuaguccuu guagccuacc agaacucugg gcccuggcac ccccuugggc cugguga         237


<210>  9828
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__CCO13834

<400>  9828
augagacccu gcagaacccu ggagauggug cccaccagag ccgagaagga caagagcgcc       60

gccgccgugc ugagagcccc cgccguggug caggagccca gacccgaggg cggcagcgug      120

cugcuggagu ggggcgugcc cagcaaggug uacccccugc uggugcugag cagaaucccc      180

aucagccccu gcagccugcc cgagcugugg gcccuggccc cccccugggc cugguga         237


<210>  9829
<211>  237
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__CCO13834

<400>  9829
augagacccu gccggacccu ggagauggug ccuacacgcg ccgaaaagga caaaagcgcu       60

gccgcggucc ucagagcucc ggccguugug caggagcccc ggccugaagg cggguccgug      120

cugcuugagu ggggaguccc cucuaaggug uacccucugc ucguucugag ccgcaucccc      180

auuuccccuu guucucuucc ggaacugugg gcccucgcuc ccccuugggc cugguga         237


<210>  9830
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__L8E8B9

<400>  9830

Met Glu Gly Arg Arg Ser Gly Cys Ser Leu Gly Thr Leu Leu Arg Pro 
1               5                   10                  15      


Gln Trp Thr Leu Pro Ala Leu Lys Thr Ser Gly Pro Thr Ala Ala Pro 
            20                  25                  30          


Ser Thr Ser Pro Trp Ile Cys His Gly Thr Thr Trp 
        35                  40                  


<210>  9831
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__CCQ43550

<400>  9831
auggagggga gaaggucugg cugcagccug gggaccuugc uccggcccca guggacacuc       60

ccagcucuga agacuucagg cccaacugca gcacccucaa cuucaccuug gaucugucac      120

ggaacaaccu gguga                                                       135


<210>  9832
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__CCQ43550

<400>  9832
auggagggcc gccggagcgg gugcucccug ggcacccucc ugcgccccca guggacccug       60

ccggcccuca agacgagcgg gcccaccgcc gcgcccucca ccagccccug gaucugccac      120

ggcaccacgu gguga                                                       135


<210>  9833
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__CCQ43550

<400>  9833
auggagggcc gccgcuccgg cugcucccuc ggcacccucc uccgccccca guggacccuc       60

cccgcccuca agaccuccgg ccccaccgcc gcccccucca ccucccccug gaucugccac      120

ggcaccaccu gguga                                                       135


<210>  9834
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__CCQ43550

<400>  9834
auggagggca gaaggagcgg gugcucccug ggaacccucc uucggcccca guggacacug       60

ccugccuuga agacuucugg uccaacggcu gcaccgucaa ccagucccug gaucugucac      120

ggcacaacuu gguga                                                       135


<210>  9835
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__CCQ43550

<400>  9835
auggagggca gaagaagcgg cugcagccug ggcacccugc ugagacccca guggacccug       60

cccgcccuga agaccagcgg ccccaccgcc gcccccagca ccagccccug gaucugccac      120

ggcaccaccu gguga                                                       135


<210>  9836
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__CCQ43550

<400>  9836
auggagggca gacggagcgg gugcucccug ggaacccucc ugcgccccca guggacacuu       60

ccugcccuga agacgucugg cccgaccgcu gcccccagca cauccccuug gaucugucac      120

gggaccacau gguga                                                       135


<210>  9837
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__Q9NR96

<400>  9837

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln 
        995                 1000                1005            


Leu Gly Met Ala Leu Thr Arg Asp Asn His His Phe Tyr Asn Arg Asn 
    1010                1015                1020                


Phe Cys Gln Gly Pro Thr Ala Glu 
1025                1030        


<210>  9838
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TLR9__Homo_sapiens__AAF72189

<400>  9838
auggguuucu gccgcagcgc ccugcacccg cugucucucc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg uaccuugccu gccuuccuac ccugugagcu ccagccccac      120

ggccugguga acugcaacug gcuguuccug aagucugugc cccacuucuc cauggcagca      180

ccccguggca augucaccag ccuuuccuug uccuccaacc gcauccacca ccuccaugau      240

ucugacuuug cccaccugcc cagccugcgg caucucaacc ucaaguggaa cugcccgccg      300

guuggccuca gccccaugca cuuccccugc cacaugacca ucgagcccag caccuucuug      360

gcugugccca cccuggaaga gcuaaaccug agcuacaaca acaucaugac ugugccugcg      420

cugcccaaau cccucauauc ccugucccuc agccauacca acauccugau gcuagacucu      480

gccagccucg ccggccugca ugcccugcgc uuccuauuca uggacggcaa cuguuauuac      540

aagaaccccu gcaggcaggc acuggaggug gccccgggug cccuccuugg ccugggcaac      600

cucacccacc ugucacucaa guacaacaac cucacugugg ugccccgcaa ccugccuucc      660

agccuggagu aucugcuguu guccuacaac cgcaucguca aacuggcgcc ugaggaccug      720

gccaaucuga ccgcccugcg ugugcucgau gugggcggaa auugccgccg cugcgaccac      780

gcucccaacc ccugcaugga gugcccucgu cacuuccccc agcuacaucc cgauaccuuc      840

agccaccuga gccgucuuga aggccuggug uugaaggaca guucucucuc cuggcugaau      900

gccaguuggu uccgugggcu gggaaaccuc cgagugcugg accugaguga gaacuuccuc      960

uacaaaugca ucacuaaaac caaggccuuc cagggccuaa cacagcugcg caagcuuaac     1020

cuguccuuca auuaccaaaa gagggugucc uuugcccacc ugucucuggc cccuuccuuc     1080

gggagccugg ucgcccugaa ggagcuggac augcacggca ucuucuuccg cucacucgau     1140

gagaccacgc uccggccacu ggcccgccug cccaugcucc agacucugcg ucugcagaug     1200

aacuucauca accaggccca gcucggcauc uucagggccu ucccuggccu gcgcuacgug     1260

gaccugucgg acaaccgcau cagcggagcu ucggagcuga cagccaccau gggggaggca     1320

gauggagggg agaaggucug gcugcagccu ggggaccuug cuccggcccc aguggacacu     1380

cccagcucug aagacuucag gcccaacugc agcacccuca acuucaccuu ggaucuguca     1440

cggaacaacc uggugaccgu gcagccggag auguuugccc agcucucgca ccugcagugc     1500

cugcgccuga gccacaacug caucucgcag gcagucaaug gcucccaguu ccugccgcug     1560

accggucugc aggugcuaga ccugucccac aauaagcugg accucuacca cgagcacuca     1620

uucacggagc uaccacgacu ggaggcccug gaccucagcu acaacagcca gcccuuuggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcucacc ugcgcacccu gcgccaccuc     1740

agccuggccc acaacaacau ccacagccaa gugucccagc agcucugcag uacgucgcug     1800

cgggcccugg acuucagcgg caaugcacug ggccauaugu gggccgaggg agaccucuau     1860

cugcacuucu uccaaggccu gagcgguuug aucuggcugg acuuguccca gaaccgccug     1920

cacacccucc ugccccaaac ccugcgcaac cuccccaaga gccuacaggu gcugcgucuc     1980

cgugacaauu accuggccuu cuuuaagugg uggagccucc acuuccugcc caaacuggaa     2040

guccucgacc uggcaggaaa ccagcugaag gcccugacca auggcagccu gccugcuggc     2100

acccggcucc ggaggcugga ugucagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uuuuccaagg ccaaggagcu gcgagagcuc aaccuuagcg ccaacgcccu caagacagug     2220

gaccacuccu gguuugggcc ccuggcgagu gcccugcaaa uacuagaugu aagcgccaac     2280

ccucugcacu gcgccugugg ggcggccuuu auggacuucc ugcuggaggu gcaggcugcc     2340

gugcccgguc ugcccagccg ggugaagugu ggcaguccgg gccagcucca gggccucagc     2400

aucuuugcac aggaccugcg ccucugccug gaugaggccc ucuccuggga cuguuucgcc     2460

cucucgcugc uggcuguggc ucugggccug ggugugccca ugcugcauca ccucuguggc     2520

ugggaccucu gguacugcuu ccaccugugc cuggccuggc uucccuggcg ggggcggcaa     2580

agugggcgag augaggaugc ccugcccuac gaugccuucg uggucuucga caaaacgcag     2640

agcgcagugg cagacugggu guacaacgag cuucgggggc agcuggagga gugccguggg     2700

cgcugggcac uccgccugug ccuggaggaa cgcgacuggc ugccuggcaa aacccucuuu     2760

gagaaccugu gggccucggu cuauggcagc cgcaagacgc uguuugugcu ggcccacacg     2820

gaccggguca guggucucuu gcgcgccagc uuccugcugg cccagcagcg ccugcuggag     2880

gaccgcaagg acgucguggu gcuggugauc cugagcccug acggccgccg cucccgcuac     2940

gugcggcugc gccagcgccu cugccgccag aguguccucc ucuggcccca ccagcccagu     3000

ggucagcgca gcuucugggc ccagcugggc auggcccuga ccagggacaa ccaccacuuc     3060

uauaaccgga acuucugcca gggacccacg gccgaauag                            3099


<210>  9839
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TLR9__Homo_sapiens__AAF72189

<400>  9839
augggcuucu gccgcagcgc ccugcacccc cucucccugc uggugcaggc caucaugcuc       60

gcgaugaccc uggcccuggg gacccucccg gccuuccugc ccugcgagcu gcagccccac      120

ggccucguca acugcaacug gcuguuccug aaguccgugc cccacuucag cauggccgcc      180

ccgcggggga acgugacgag ccucucccug agcuccaacc gcauccacca ccuccacgac      240

agcgacuucg cgcaccuccc cucccugcgg caccugaacc ucaaguggaa cugcccgccc      300

gucggccuga gccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccug      360

gccgugccca cccucgagga gcugaaccug agcuacaaca acaucaugac ggugccggcc      420

cuccccaagu cccugaucag ccugucccuc agccacacca acauccugau gcuggacucc      480

gccagccucg cggggcugca cgcccugcgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccggcaggc ccuggagguc gcccccggcg cccugcucgg gcugggcaac      600

cugacccacc ucucccugaa guacaacaac cugaccgugg ugccgcgcaa ccuccccagc      660

agccuggagu accugcuccu guccuacaac cggaucguca agcuggcgcc cgaggaccuc      720

gccaaccuga cggcccugcg cgugcuggac gucgggggca acugccggcg cugcgaccac      780

gcccccaacc cgugcaugga gugcccccgg cacuuccccc agcuccaccc cgacaccuuc      840

agccaccugu cccgccugga ggggcucgug cugaaggaca gcucccugag cuggcucaac      900

gccuccuggu uccggggccu gggcaaccug cgcgugcucg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggcguuc caggggcuca cgcagcugcg gaagcugaac     1020

cucuccuuca acuaccagaa gcgcgugagc uucgcccacc ugucccuggc cccgagcuuc     1080

ggcucccucg ucgcccugaa ggagcuggac augcacggga ucuucuuccg gagccucgac     1140

gagaccaccc ugcgcccccu ggcccggcuc cccaugcugc agacccugcg ccuccagaug     1200

aacuucauca accaggcgca gcugggcauc uuccgggccu uccccggccu gcgcuacgug     1260

gaccucuccg acaaccgcau cagcggggcc uccgagcuga cggccaccau gggcgaggcc     1320

gacgggggcg agaaggugug gcugcagccg ggggaccucg cgcccgcccc cgucgacacc     1380

ccgagcuccg aggacuuccg gcccaacugc agcacccuga acuucacgcu ggaccucagc     1440

cgcaacaacc uggugaccgu gcagcccgag auguucgccc agcuguccca ccuccagugc     1500

cugcggcuga gccacaacug caucucccag gccgucaacg gcagccaguu ccucccccug     1560

accggccucc aggugcugga ccugucccac aacaagcugg accucuacca cgagcacagc     1620

uucaccgagc ugccgcgccu ggaggcgcuc gaccuguccu acaacagcca gcccuucggg     1680

augcagggcg uggggcacaa cuucuccuuc gucgcccacc uccggacgcu gcgccaccug     1740

agccuggccc acaacaacau ccacucccag gugagccagc agcucugcuc caccagccug     1800

cgggcccugg acuucuccgg caacgcccuc gggcacaugu gggcggaggg cgaccuguac     1860

cugcacuucu uccagggccu cagcgggcug aucuggcugg accucuccca gaaccgccug     1920

cacacccugc ucccccagac ccugcggaac cugcccaaga gccuccaggu ccugcgccug     1980

cgggacaacu accucgccuu cuucaagugg uggagccugc acuuccugcc gaagcucgag     2040

gugcuggacc uggccggcaa ccagcucaag gcccugacga acgggucccu gcccgccggc     2100

acccgccucc ggcgccugga cgugagcugc aacuccauca gcuucgucgc gcccggguuc     2160

uucuccaagg ccaaggagcu gcgggagcuc aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacuccu gguucggccc ccucgccagc gcgcugcaga uccuggacgu guccgccaac     2280

ccgcuccacu gcgccugcgg cgccgcguuc auggacuucc ugcuggaggu ccaggccgcc     2340

gugcccgggc ugcccagccg cgugaagugc ggcucccccg ggcagcucca gggccugagc     2400

aucuucgccc aggaccugcg gcucugccug gacgaggccc uguccuggga cugcuucgcg     2460

cucagccugc uggccgucgc ccucggccug ggggugccga ugcugcacca ccucugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cucgccuggc ugcccuggcg cgggcggcag     2580

uccggccgcg acgaggacgc ccugcccuac gacgcguucg uggucuucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cuccgcgggc agcuggagga gugccggggc     2700

cgcugggccc ugcggcucug ccuggaggag cgcgacuggc ugcccggcaa gacgcuguuc     2760

gagaaccugu gggccuccgu cuacgggagc cggaagaccc uguucgugcu cgcgcacacc     2820

gaccgcgugu ccggccugcu gcgggccagc uuccuccugg cccagcagcg ccugcucgag     2880

gaccggaagg acgucguggu gcuggucauc cugagcccgg acgggcgccg gucccgcuac     2940

gugcggcucc gccagcggcu gugccgccag agcgugcugc ucuggcccca ccagcccucc     3000

ggccagcgga gcuucugggc ccagcugggg auggcgcuga cccgcgacaa ccaccacuuc     3060

uacaaccgga acuucugcca gggccccacg gccgaguga                            3099


<210>  9840
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TLR9__Homo_sapiens__AAF72189

<400>  9840
augggcuucu gccgcuccgc ccuccacccc cucucccucc ucguccaggc caucaugcuc       60

gccaugaccc ucgcccucgg cacccucccc gccuuccucc ccugcgagcu ccagccccac      120

ggccucguca acugcaacug gcucuuccuc aaguccgucc cccacuucuc cauggccgcc      180

ccccgcggca acgucaccuc ccucucccuc uccuccaacc gcauccacca ccuccacgac      240

uccgacuucg cccaccuccc cucccuccgc caccucaacc ucaaguggaa cugccccccc      300

gucggccucu cccccaugca cuuccccugc cacaugacca ucgagcccuc caccuuccuc      360

gccgucccca cccucgagga gcucaaccuc uccuacaaca acaucaugac cguccccgcc      420

cuccccaagu cccucaucuc ccucucccuc ucccacacca acauccucau gcucgacucc      480

gccucccucg ccggccucca cgcccuccgc uuccucuuca uggacggcaa cugcuacuac      540

aagaaccccu gccgccaggc ccucgagguc gcccccggcg cccuccucgg ccucggcaac      600

cucacccacc ucucccucaa guacaacaac cucaccgucg ucccccgcaa ccuccccucc      660

ucccucgagu accuccuccu cuccuacaac cgcaucguca agcucgcccc cgaggaccuc      720

gccaaccuca ccgcccuccg cguccucgac gucggcggca acugccgccg cugcgaccac      780

gcccccaacc ccugcaugga gugcccccgc cacuuccccc agcuccaccc cgacaccuuc      840

ucccaccucu cccgccucga gggccucguc cucaaggacu ccucccucuc cuggcucaac      900

gccuccuggu uccgcggccu cggcaaccuc cgcguccucg accucuccga gaacuuccuc      960

uacaagugca ucaccaagac caaggccuuc cagggccuca cccagcuccg caagcucaac     1020

cucuccuuca acuaccagaa gcgcgucucc uucgcccacc ucucccucgc ccccuccuuc     1080

ggcucccucg ucgcccucaa ggagcucgac augcacggca ucuucuuccg cucccucgac     1140

gagaccaccc uccgcccccu cgcccgccuc cccaugcucc agacccuccg ccuccagaug     1200

aacuucauca accaggccca gcucggcauc uuccgcgccu uccccggccu ccgcuacguc     1260

gaccucuccg acaaccgcau cuccggcgcc uccgagcuca ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggucug gcuccagccc ggcgaccucg cccccgcccc cgucgacacc     1380

cccuccuccg aggacuuccg ccccaacugc uccacccuca acuucacccu cgaccucucc     1440

cgcaacaacc ucgucaccgu ccagcccgag auguucgccc agcucuccca ccuccagugc     1500

cuccgccucu cccacaacug caucucccag gccgucaacg gcucccaguu ccucccccuc     1560

accggccucc agguccucga ccucucccac aacaagcucg accucuacca cgagcacucc     1620

uucaccgagc ucccccgccu cgaggcccuc gaccucuccu acaacuccca gcccuucggc     1680

augcagggcg ucggccacaa cuucuccuuc gucgcccacc uccgcacccu ccgccaccuc     1740

ucccucgccc acaacaacau ccacucccag gucucccagc agcucugcuc caccucccuc     1800

cgcgcccucg acuucuccgg caacgcccuc ggccacaugu gggccgaggg cgaccucuac     1860

cuccacuucu uccagggccu cuccggccuc aucuggcucg accucuccca gaaccgccuc     1920

cacacccucc ucccccagac ccuccgcaac cuccccaagu cccuccaggu ccuccgccuc     1980

cgcgacaacu accucgccuu cuucaagugg uggucccucc acuuccuccc caagcucgag     2040

guccucgacc ucgccggcaa ccagcucaag gcccucacca acggcucccu ccccgccggc     2100

acccgccucc gccgccucga cgucuccugc aacuccaucu ccuucgucgc ccccggcuuc     2160

uucuccaagg ccaaggagcu ccgcgagcuc aaccucuccg ccaacgcccu caagaccguc     2220

gaccacuccu gguucggccc ccucgccucc gcccuccaga uccucgacgu cuccgccaac     2280

ccccuccacu gcgccugcgg cgccgccuuc auggacuucc uccucgaggu ccaggccgcc     2340

guccccggcc uccccucccg cgucaagugc ggcucccccg gccagcucca gggccucucc     2400

aucuucgccc aggaccuccg ccucugccuc gacgaggccc ucuccuggga cugcuucgcc     2460

cucucccucc ucgccgucgc ccucggccuc ggcgucccca ugcuccacca ccucugcggc     2520

ugggaccucu gguacugcuu ccaccucugc cucgccuggc uccccuggcg cggccgccag     2580

uccggccgcg acgaggacgc ccuccccuac gacgccuucg ucgucuucga caagacccag     2640

uccgccgucg ccgacugggu cuacaacgag cuccgcggcc agcucgagga gugccgcggc     2700

cgcugggccc uccgccucug ccucgaggag cgcgacuggc uccccggcaa gacccucuuc     2760

gagaaccucu gggccuccgu cuacggcucc cgcaagaccc ucuucguccu cgcccacacc     2820

gaccgcgucu ccggccuccu ccgcgccucc uuccuccucg cccagcagcg ccuccucgag     2880

gaccgcaagg acgucgucgu ccucgucauc cucucccccg acggccgccg cucccgcuac     2940

guccgccucc gccagcgccu cugccgccag uccguccucc ucuggcccca ccagcccucc     3000

ggccagcgcu ccuucugggc ccagcucggc auggcccuca cccgcgacaa ccaccacuuc     3060

uacaaccgca acuucugcca gggccccacc gccgaguga                            3099


<210>  9841
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TLR9__Homo_sapiens__AAF72189

<400>  9841
augggcuucu gcagaagcgc ccugcacccc cucucccuuc uggugcaggc uaucauguug       60

gcaaugaccu uagcccuggg gacacuaccu gcguuucucc caugugagcu gcaaccgcau      120

ggacuuguca acugcaauug gcuguucuug aagucuguuc cccacuuuuc aauggcugcc      180

ccuaggggua acgugacgag ucucagccug uccucuaauc ggauucauca ccuucaugac      240

ucggauuucg cacaccuccc aucauuacgc caccugaacc uuaaauggaa uugucccccu      300

guaggcuuga gcccaaugca uuuucccugc cacaugacua uagaaccuag uaccuuccug      360

gccgugccaa cacuagagga acucaaccug uccuacaaua acaucaugac ugucccggcu      420

cugcccaagu cucugauuag cuugucccuc ucacauacca auauccugau guuagacagu      480

gcaagccugg ccgggcucca cgcucugcga uuucuguuca uggauggaaa cuguuauuac      540

aaaaauccuu gccgucaggc cuuggaggug gcgccaggcg cacuacuggg ucucgggaac      600

cugacacacc uuucucugaa guauaauaac uugaccguug ugcccagaaa ucucccuucc      660

ucacuggaau acuuacugcu aagcuauaac aggauuguca aacucgcccc agaggaccug      720

gcuaaccuua cugccuugcg ggugcuggau guaggaggca auugucgcag augcgaccau      780

gcacccaacc cguguaugga gugcccuagg cacuuucccc agcuccaucc agauacauuc      840

agucaccugu cucggcuuga aggccugguu uugaaggacu ccagccucuc guggcugaau      900

gcuucuuggu uucgcggguu aggaaaccug cgagugcuag aucucuccga gaauuuccug      960

uacaagugua ucaccaaaac gaaggccuuu cagggucuua cucaauugag aaaacugaac     1020

cucucauuca auuaucagaa gagggucagu uucgcgcauc ugagcuuagc cccuuccuuu     1080

ggcucucugg uggcacuuaa agaauuggac augcacggga uauucuuucg gagccucgau     1140

gagaccacac ugcguccccu agcucgccug ccaaugcucc agacucugag acuucagaug     1200

aacuucauca aucaagccca guugggaauu uuuagggcuu uccccggccu gcgguacgug     1260

gacuuaucag auaaccgaau caguggugcc uccgagcuca ccgcaacaau gggggaagcc     1320

gacggaggcg agaaggucug gcugcagccu ggcgaccuug cuccagcgcc gguugauacc     1380

cccagcucug aagacuuucg cccuaauugc ucaacgcuga acuucacuuu ggaucucagu     1440

agaaauaacc uggugacagu acagccagag auguuugcac aacuaagcca ccuucagugc     1500

cucaggcugu cccauaauug uauuucucag gccgugaacg ggucgcaauu ccuucccuug     1560

accggacugc aggucuuaga ccucagccac aacaagcugg aucuuuacca ugaacacucc     1620

uuuacugagc ugccucggcu agaggcucuc gaccugucau auaauaguca gccauucggu     1680

augcagggcg uggggcacaa cuuuucuuuc guugcccauu ugcgcacacu gagacacuua     1740

agccucgcac auaauaacau ccacucccaa gugucacagc agcugugcag caccucucuu     1800

agggcccugg auuucuccgg aaaugcuuug ggccauaugu gggccgaagg ugaccucuac     1860

cugcacuuuu uccaggggcu aaguggccug auauggcuug aucucagcca aaaccgucug     1920

cacacguugc ugccccagac cuuacggaau cucccgaaau cucugcaggu ccuucgacug     1980

agagacaacu auuuggcauu uuucaagugg uggucccucc auuuucugcc uaaacuagag     2040

gugcuggauc uugcgggaaa ucagcucaag gcucugacaa acggcucauu gccagccggg     2100

acuagguuac gccggcugga cguaaguugu aauagcauuu cguucguugc acccggauuu     2160

uucuccaaag ccaaggaacu cagagagcug aaccuuucug cuaaugcccu gaaaaccgug     2220

gaccacagcu gguuuggucc uuuggcauca gcucuacaaa uccuggaugu cagugccaac     2280

ccccuccauu gcgcgugugg cgccgcuuuc auggacuuuc ugcuugaagu gcaggcagcc     2340

gucccagggu uaccuuccag ggugaagugc ggaucucccg gccagcugca gggucucagc     2400

auuuucgcuc aagauuugcg ccugugucuc gacgaggccc uguccuggga uugcuuugca     2460

cuuucacugu uggcgguugc ccuagggcug ggcgugccaa ugcuccacca uuuaugugga     2520

ugggaccugu gguacugcuu ccaccuuugu cuggcuuggc ucccguggcg aggccggcag     2580

agcgggcgug augaggacgc cuugccuuau gaugcauucg uagucuuuga caagacacag     2640

agugcugugg ccgauugggu uuacaaugaa cugagaggac aacucgagga augcaggggu     2700

cgcugggcac ugcggcuuug ccuagaggaa agagacuggc ugcccggcaa aacuuuguuc     2760

gagaacuuau gggccucugu guaugggucc aggaagaccc uguuuguccu cgcucacaca     2820

gaucgaguga gcggacugcu ucgcgcgucg uuccugcucg cccagcagcg guugcuggag     2880

gacagaaaag acguaguggu ucuagucauc cugucaccag auggcaggcg uucucgcuac     2940

gugcggcuca gacagaggcu uugucgacaa agugugcugu uauggcccca ucagccuucc     3000

ggucagcgga gcuuuugggc acaguugggg auggcucuga cccgcgacaa ccaccauuuc     3060

uacaauagaa acuuuugcca aggcccaacu gccgaauga                            3099


<210>  9842
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TLR9__Homo_sapiens__AAF72189

<400>  9842
augggcuucu gcagaagcgc ccugcacccc cugagccugc uggugcaggc caucaugcug       60

gccaugaccc uggcccuggg cacccugccc gccuuccugc ccugcgagcu gcagccccac      120

ggccugguga acugcaacug gcuguuccug aagagcgugc cccacuucag cauggccgcc      180

cccagaggca acgugaccag ccugagccug agcagcaaca gaauccacca ccugcacgac      240

agcgacuucg cccaccugcc cagccugaga caccugaacc ugaaguggaa cugccccccc      300

gugggccuga gccccaugca cuuccccugc cacaugacca ucgagcccag caccuuccug      360

gccgugccca cccuggagga gcugaaccug agcuacaaca acaucaugac cgugcccgcc      420

cugcccaaga gccugaucag ccugagccug agccacacca acauccugau gcuggacagc      480

gccagccugg ccggccugca cgcccugaga uuccuguuca uggacggcaa cugcuacuac      540

aagaaccccu gcagacaggc ccuggaggug gcccccggcg cccugcuggg ccugggcaac      600

cugacccacc ugagccugaa guacaacaac cugaccgugg ugcccagaaa ccugcccagc      660

agccuggagu accugcugcu gagcuacaac agaaucguga agcuggcccc cgaggaccug      720

gccaaccuga ccgcccugag agugcuggac gugggcggca acugcagaag augcgaccac      780

gcccccaacc ccugcaugga gugccccaga cacuuccccc agcugcaccc cgacaccuuc      840

agccaccuga gcagacugga gggccuggug cugaaggaca gcagccugag cuggcugaac      900

gccagcuggu ucagaggccu gggcaaccug agagugcugg accugagcga gaacuuccug      960

uacaagugca ucaccaagac caaggccuuc cagggccuga cccagcugag aaagcugaac     1020

cugagcuuca acuaccagaa gagagugagc uucgcccacc ugagccuggc ccccagcuuc     1080

ggcagccugg uggcccugaa ggagcuggac augcacggca ucuucuucag aagccuggac     1140

gagaccaccc ugagaccccu ggccagacug cccaugcugc agacccugag acugcagaug     1200

aacuucauca accaggccca gcugggcauc uucagagccu uccccggccu gagauacgug     1260

gaccugagcg acaacagaau cagcggcgcc agcgagcuga ccgccaccau gggcgaggcc     1320

gacggcggcg agaaggugug gcugcagccc ggcgaccugg cccccgcccc cguggacacc     1380

cccagcagcg aggacuucag acccaacugc agcacccuga acuucacccu ggaccugagc     1440

agaaacaacc uggugaccgu gcagcccgag auguucgccc agcugagcca ccugcagugc     1500

cugagacuga gccacaacug caucagccag gccgugaacg gcagccaguu ccugccccug     1560

accggccugc aggugcugga ccugagccac aacaagcugg accuguacca cgagcacagc     1620

uucaccgagc ugcccagacu ggaggcccug gaccugagcu acaacagcca gcccuucggc     1680

augcagggcg ugggccacaa cuucagcuuc guggcccacc ugagaacccu gagacaccug     1740

agccuggccc acaacaacau ccacagccag gugagccagc agcugugcag caccagccug     1800

agagcccugg acuucagcgg caacgcccug ggccacaugu gggccgaggg cgaccuguac     1860

cugcacuucu uccagggccu gagcggccug aucuggcugg accugagcca gaacagacug     1920

cacacccugc ugccccagac ccugagaaac cugcccaaga gccugcaggu gcugagacug     1980

agagacaacu accuggccuu cuucaagugg uggagccugc acuuccugcc caagcuggag     2040

gugcuggacc uggccggcaa ccagcugaag gcccugacca acggcagccu gcccgccggc     2100

accagacuga gaagacugga cgugagcugc aacagcauca gcuucguggc ccccggcuuc     2160

uucagcaagg ccaaggagcu gagagagcug aaccugagcg ccaacgcccu gaagaccgug     2220

gaccacagcu gguucggccc ccuggccagc gcccugcaga uccuggacgu gagcgccaac     2280

ccccugcacu gcgccugcgg cgccgccuuc auggacuucc ugcuggaggu gcaggccgcc     2340

gugcccggcc ugcccagcag agugaagugc ggcagccccg gccagcugca gggccugagc     2400

aucuucgccc aggaccugag acugugccug gacgaggccc ugagcuggga cugcuucgcc     2460

cugagccugc uggccguggc ccugggccug ggcgugccca ugcugcacca ccugugcggc     2520

ugggaccugu gguacugcuu ccaccugugc cuggccuggc ugcccuggag aggcagacag     2580

agcggcagag acgaggacgc ccugcccuac gacgccuucg ugguguucga caagacccag     2640

agcgccgugg ccgacugggu guacaacgag cugagaggcc agcuggagga gugcagaggc     2700

agaugggccc ugagacugug ccuggaggag agagacuggc ugcccggcaa gacccuguuc     2760

gagaaccugu gggccagcgu guacggcagc agaaagaccc uguucgugcu ggcccacacc     2820

gacagaguga gcggccugcu gagagccagc uuccugcugg cccagcagag acugcuggag     2880

gacagaaagg acgugguggu gcuggugauc cugagccccg acggcagaag aagcagauac     2940

gugagacuga gacagagacu gugcagacag agcgugcugc uguggcccca ccagcccagc     3000

ggccagagaa gcuucugggc ccagcugggc auggcccuga ccagagacaa ccaccacuuc     3060

uacaacagaa acuucugcca gggccccacc gccgaguga                            3099


<210>  9843
<211>  3099
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TLR9__Homo_sapiens__AAF72189

<400>  9843
augggcuucu gcagaagcgc ccugcacccc cucucccugc uugugcaggc uaucaugcug       60

gccaugaccc ucgcgcuggg gacacuuccu gcuuuucugc cgugugagcu ccaaccccau      120

ggacugguca acugcaauug gcuguuccuc aagucuguuc cucacuuuag cauggccgcu      180

ccccggggca acgugacguc ccugucucuu agcuccaauc gcauucauca ucugcacgac      240

ucugauuucg cucaccuccc uagccugaga caccuuaacc ugaaauggaa uugucccccu      300

guggggcucu ccccgaugca uuuucccugc cacaugacca ucgaaccuag cacauuccug      360

gccgucccca cccuggagga acucaaccug ucuuacaaua acauuaugac agugccugcu      420

cugcccaagu cccugaucag ccucucucug ucccauacca auauucuuau gcuggacagc      480

gccucucucg cgggacugca cgcccugcgg uuucucuuca uggauggcaa cuguuauuac      540

aaaaauccgu gccgccaggc ucuggagguu gccccugggg cccuucuggg acucggcaac      600

cugacacacc uuucccugaa guauaauaac cucaccgugg uccccagaaa ucugccuagc      660

ucccuggaau accuccugcu uucuuauaac cggaucguga aacuggcccc cgaggaccuc      720

gcgaaccuga cggcccugcg cguucuugau gugggcggga auuguagacg gugcgaccau      780

gcucccaacc cuuguaugga gugcccgcgc cacuuucccc agcuccaucc ugauaccuuc      840

agccaccugu ccagacugga aggacucguc cugaaggaca gcucucuuuc cuggcugaau      900

gccagcuggu uucggggccu cgggaaccug cgcgugcugg aucuuucuga gaauuuccuc      960

uacaagugua ucacaaaaac caaggcuuuu cagggacuga cacaacugag aaaacucaac     1020

cugagcuuca auuaucagaa gcgggugucc uucgcccauc uuucucuggc ccccagcuuu     1080

ggcucccucg ucgcucugaa agaacuggac augcacggga uuuucuuucg cagccuugau     1140

gagaccacgc ucagaccucu ggcgcggcug cccaugcucc agacacugag acuucagaug     1200

aacuucauca aucaagccca gcugggaauu uuucgcgcuu ucccgggccu ccgguacguu     1260

gaccugucug auaacagaau cuccggcgcc agcgagcuga ccgccacaau gggggaagcu     1320

gacggaggcg agaaggugug gcuucagccu ggggaccucg cccccgcgcc uguggauacc     1380

cccucuuccg aagacuuucg cccuaauugc agcacccuga acuucacacu ggaucucucc     1440

cggaauaacc uggucacggu gcagcccgag auguuugcuc aacuuucuca ucugcagugc     1500

cucagacuga gccacaauug uauuucccag gccguuaacg gaucucaauu ccugccgcuu     1560

accggccuuc aggugcucga ccugagccac aacaagcucg aucuguacca ugaacacucc     1620

uuuacagagc uuccucgccu ggaggcccuc gaccugagcu auaauucuca gcccuucggg     1680

augcagggag ucggccacaa cuuuuccuuc guggcucauc ugcggacccu uagacaccug     1740

agccucgccc auaauaacau ccacucucaa guuucccagc agcugugcag cacaucucuc     1800

cgcgcucugg auuucagcgg caaugcccuu gggcauaugu gggcggaagg agaccuguac     1860

cuccacuuuu uccagggccu guccgggcug auuuggcuug aucugagcca aaaccggcuc     1920

cacacccugc ucccccagac gcugagaaau cuuccuaaau cucuccaggu gcugcgccug     1980

cgggacaacu aucuggccuu uuucaagugg uggucccuuc auuuucugcc gaaacucgag     2040

guccuggauc ucgcuggaaa ucagcugaag gcccuuacaa acggcagccu gcccgcuggg     2100

accagacugc ggcgccucga cguguccugu aauucuauca gcuucgucgc cccuggcuuu     2160

uucuccaaag cgaaggaacu gagagagcuu aaccugucug ccaaugcucu caaaaccgug     2220

gaccacagcu gguuuggacc ccuggccucc gcucuccaaa uccuggaugu uucugccaac     2280

ccucuucauu gcgccugugg cgcugcguuc auggacuuuc ugcuggaagu gcaggccgcu     2340

guccccgggc ucccuagccg ggugaagugc ggaucccccg gccagcugca ggggcuuagc     2400

auuuucgccc aagaucugag acucugucug gacgaggccc ucucuuggga uugcuuugcu     2460

cugucccuuc uggccguugc gcugggacuc ggcgugccga ugcugcacca ucuuuguggg     2520

ugggaccugu gguacugcuu ccaccucugu cuggcuuggc ugccuuggcg cggccggcag     2580

agcggaagag augaggacgc ccuccccuau gaugccuucg ucguguuuga caagacacag     2640

ucugcugugg ccgauugggu uuacaaugaa cuucgcggcc aacuggagga augcagaggg     2700

cggugggcgc ugcgccucug ccuggaggaa agagacuggc uuccuggaaa aacccuguuc     2760

gagaaccucu gggcuuccgu cuauggcagc cggaagacac uguuugugcu ggcccacacg     2820

gaucgcgugu cugggcuccu uagagccucc uuccugcugg cucagcagcg gcuccuggag     2880

gaccgcaaag acgucguggu ucuugugauc cugagccccg auggaagacg gucccgcuac     2940

gucagacucc ggcagagacu gugucgccaa agcgugcugc ucuggccgca ucagccuucu     3000

ggccagcgga gcuuuugggc ccagcuuggg auggcucuga ccagagacaa ccaccauuuc     3060

uacaaucgca acuuuugcca aggccccaca gccgaauga                            3099


<210>  9844
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TRAF6__Homo_sapiens__Q9Y4K3

<400>  9844

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr 
        275                 280                 285             


Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His Gln Leu Glu Gly 
    290                 295                 300                 


Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu Thr Ala Lys Met 
305                 310                 315                 320 


Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg Thr Ile Arg Thr 
                325                 330                 335     


Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile 
            340                 345                 350         


Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu Lys Cys Gln Glu 
        355                 360                 365             


Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe Tyr Thr Gly Lys 
    370                 375                 380                 


Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln Leu Pro Thr Ala 
385                 390                 395                 400 


Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His Thr Met Gln Gly 
                405                 410                 415     


Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu 
            420                 425                 430         


Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln Asn His Glu Glu 
        435                 440                 445             


Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile 
    450                 455                 460                 


Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe Met His Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr Leu Leu Val Arg 
                485                 490                 495     


Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu Arg Arg Glu Gly 
            500                 505                 510         


Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
        515                 520         


<210>  9845
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  TRAF6__Homo_sapiens__AAB38751

<400>  9845
augagucugc uaaacuguga aaacagcugu ggauccagcc agucugaaag ugacugcugu       60

guggccaugg ccagcuccug uagcgcugua acaaaagaug auaguguggg uggaacugcc      120

agcacgggga accucuccag cucauuuaug gaggagaucc agggauauga uguagaguuu      180

gacccacccc uggaaagcaa guaugaaugc cccaucugcu ugauggcauu acgagaagca      240

gugcaaacgc caugcggcca uagguucugc aaagccugca ucauaaaauc aauaagggau      300

gcaggucaca aauguccagu ugacaaugaa auacugcugg aaaaucaacu auuuccagac      360

aauuuugcaa aacgugagau ucuuucucug auggugaaau guccaaauga agguuguuug      420

cacaagaugg aacugagaca ucuugaggau caucaagcac auugugaguu ugcucuuaug      480

gauugucccc aaugccagcg ucccuuccaa aaauuccaua uuaauauuca cauucugaag      540

gauuguccaa ggagacaggu uucuugugac aacugugcug caucaauggc auuugaagau      600

aaagagaucc augaccagaa cuguccuuug gcaaauguca ucugugaaua cugcaauacu      660

auacucauca gagaacagau gccuaaucau uaugaucuag acugcccuac agccccaauu      720

ccaugcacau ucaguacuuu ugguugccau gaaaagaugc agaggaauca cuuggcacgc      780

caccuacaag agaacaccca gucacacaug agaauguugg cccaggcugu ucauaguuug      840

agcguuauac ccgacucugg guauaucuca gagguccgga auuuccagga aacuauucac      900

caguuagagg gucgccuugu aagacaagac caucaaaucc gggagcugac ugcuaaaaug      960

gaaacucaga guauguaugu aagugagcuc aaacgaacca uucgaacccu ugaggacaaa     1020

guugcugaaa ucgaagcaca gcagugcaau ggaauuuaua uuuggaagau uggcaacuuu     1080

ggaaugcauu ugaaauguca agaagaggag aaaccuguug ugauucauag cccuggauuc     1140

uacacuggca aacccgggua caaacugugc augcgcuugc accuucaguu accgacugcu     1200

cagcgcugug caaacuauau aucccuuuuu guccacacaa ugcaaggaga auaugacagc     1260

caccucccuu ggcccuucca ggguacaaua cgccuuacaa uucuugauca gucugaagca     1320

ccuguaaggc aaaaccacga agagauaaug gaugccaaac cagagcugcu ugcuuuccag     1380

cgacccacaa ucccacggaa cccaaaaggu uuuggcuaug uaacuuuuau gcaucuggaa     1440

gcccuaagac aaagaacuuu cauuaaggau gacacauuau uagugcgcug ugaggucucc     1500

acccgcuuug acauggguag ccuucggagg gaggguuuuc agccacgaag uacugaugca     1560

gggguauag                                                             1569


<210>  9846
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       TRAF6__Homo_sapiens__AAB38751

<400>  9846
augagccugc ucaacugcga gaacuccugc ggcagcuccc agagcgaguc cgacugcugc       60

guggccaugg ccagcuccug cagcgcgguc accaaggacg acuccgucgg gggcaccgcc      120

agcacgggga accuguccag cuccuucaug gaggagaucc agggcuacga cguggaguuc      180

gacccgcccc uggagagcaa guacgagugc cccaucugcc ucauggcccu gcgcgaggcc      240

gugcagaccc ccugcgggca ccgguucugc aaggccugca ucaucaaguc cauccgcgac      300

gcgggccaca agugccccgu ggacaacgag auccugcucg agaaccagcu guucccggac      360

aacuucgcca agcgggagau ccugagccuc auggugaagu gccccaacga gggcugccug      420

cacaagaugg agcugcgcca ccucgaggac caccaggccc acugcgaguu cgcccugaug      480

gacugccccc agugccagcg gcccuuccag aaguuccaca ucaacaucca cauccugaag      540

gacugcccgc gccggcaggu cuccugcgac aacugcgcgg ccagcauggc cuucgaggac      600

aaggagaucc acgaccagaa cugcccccuc gccaacguga ucugcgagua cugcaacacc      660

auccugaucc gcgagcagau gcccaaccac uacgaccugg acugccccac cgccccgauc      720

cccugcacgu ucuccaccuu cgggugccac gagaagaugc agcggaacca ccucgcgcgc      780

caccuccagg agaacaccca gagccacaug cggaugcugg cccaggccgu gcacagccug      840

uccgucaucc ccgacagcgg cuacaucucc gaggugcgca acuuccagga gaccauccac      900

cagcuggagg ggcggcuggu gcgccaggac caccagaucc gggagcucac ggccaagaug      960

gagacccaga gcauguacgu cuccgagcug aagcgcacca uccggacccu ggaggacaag     1020

guggccgaga ucgaggcgca gcagugcaac ggcaucuaca ucuggaagau cgggaacuuc     1080

ggcaugcacc ucaagugcca ggaggaggag aagcccgugg ucauccacag cccgggcuuc     1140

uacacgggga agcccggcua caagcugugc augcgccugc accuccagcu gcccaccgcc     1200

cagcggugcg ccaacuacau cucccuguuc gugcacacca ugcaggggga guacgacagc     1260

caccuccccu ggccguucca gggcaccauc cgccugacga uccuggacca guccgaggcc     1320

cccgugcggc agaaccacga ggagaucaug gacgccaagc ccgagcuccu ggcguuccag     1380

cgccccacca ucccgcgcaa ccccaagggc uucggguacg ucaccuucau gcaccuggag     1440

gcccuccggc agcgcaccuu caucaaggac gacacgcugc uggugcggug cgaggugagc     1500

acccgcuucg acaugggcuc ccuccggcgc gagggguucc agccccggag caccgacgcc     1560

ggcgucuga                                                             1569


<210>  9847
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       TRAF6__Homo_sapiens__AAB38751

<400>  9847
augucccucc ucaacugcga gaacuccugc ggcuccuccc aguccgaguc cgacugcugc       60

gucgccaugg ccuccuccug cuccgccguc accaaggacg acuccgucgg cggcaccgcc      120

uccaccggca accucuccuc cuccuucaug gaggagaucc agggcuacga cgucgaguuc      180

gacccccccc ucgaguccaa guacgagugc cccaucugcc ucauggcccu ccgcgaggcc      240

guccagaccc ccugcggcca ccgcuucugc aaggccugca ucaucaaguc cauccgcgac      300

gccggccaca agugccccgu cgacaacgag auccuccucg agaaccagcu cuuccccgac      360

aacuucgcca agcgcgagau ccucucccuc auggucaagu gccccaacga gggcugccuc      420

cacaagaugg agcuccgcca ccucgaggac caccaggccc acugcgaguu cgcccucaug      480

gacugccccc agugccagcg ccccuuccag aaguuccaca ucaacaucca cauccucaag      540

gacugccccc gccgccaggu cuccugcgac aacugcgccg ccuccauggc cuucgaggac      600

aaggagaucc acgaccagaa cugcccccuc gccaacguca ucugcgagua cugcaacacc      660

auccucaucc gcgagcagau gcccaaccac uacgaccucg acugccccac cgcccccauc      720

cccugcaccu ucuccaccuu cggcugccac gagaagaugc agcgcaacca ccucgcccgc      780

caccuccagg agaacaccca gucccacaug cgcaugcucg cccaggccgu ccacucccuc      840

uccgucaucc ccgacuccgg cuacaucucc gagguccgca acuuccagga gaccauccac      900

cagcucgagg gccgccucgu ccgccaggac caccagaucc gcgagcucac cgccaagaug      960

gagacccagu ccauguacgu cuccgagcuc aagcgcacca uccgcacccu cgaggacaag     1020

gucgccgaga ucgaggccca gcagugcaac ggcaucuaca ucuggaagau cggcaacuuc     1080

ggcaugcacc ucaagugcca ggaggaggag aagcccgucg ucauccacuc ccccggcuuc     1140

uacaccggca agcccggcua caagcucugc augcgccucc accuccagcu ccccaccgcc     1200

cagcgcugcg ccaacuacau cucccucuuc guccacacca ugcagggcga guacgacucc     1260

caccuccccu ggcccuucca gggcaccauc cgccucacca uccucgacca guccgaggcc     1320

cccguccgcc agaaccacga ggagaucaug gacgccaagc ccgagcuccu cgccuuccag     1380

cgccccacca ucccccgcaa ccccaagggc uucggcuacg ucaccuucau gcaccucgag     1440

gcccuccgcc agcgcaccuu caucaaggac gacacccucc ucguccgcug cgaggucucc     1500

acccgcuucg acaugggcuc ccuccgccgc gagggcuucc agccccgcuc caccgacgcc     1560

ggcgucuga                                                             1569


<210>  9848
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       TRAF6__Homo_sapiens__AAB38751

<400>  9848
augagccugc ucaacugcga aaauuccugu gggucuucac agagugagag cgacugcugu       60

guggccaugg cuuccucuug cucggcaguc accaaggaug acucaguugg cggaacagcc      120

agcacuggua accuuaguuc cucuuucaug gaggaaaucc aaggcuacga uguggaguuu      180

gaucccccuc uggaaagcaa auaugagugu ccaauuugcu ugauggcguu aagagaggcu      240

guacagacgc cgugugggca cagguucugc aaggccugua uaaucaaauc cauucgggac      300

gcaggacaua agugccccgu ggacaaugaa auccugcuag agaaccagcu cuuuccugau      360

aauuucgcca aacgcgaaau ucugucacuu auggucaagu guccaaacga gggcugccug      420

cacaagaugg aguugcgaca ucucgaagac caccaggcuc auugcgaguu ugcacugaug      480

gauugucccc aaugccagcg uccuuuccag aaauuucaca ucaauauaca cauccugaag      540

gacuguccaa gacgccaggu gaguugcgau aacugugccg cuagcauggc cuucgaagac      600

aaagagauuc augaucaaaa uugcccccuc gcgaacguua ucugugaaua cugcaauacc      660

auuuuaaucc gggagcagau gccuaaccac uaugaccugg acuguccaac agcaccgaua      720

cccugcacuu uuucuaccuu cgguugucau gagaagaugc agcgcaauca ccuugccaga      780

cacuugcagg aaaacacaca aucccauaug aggaugcugg cucaggccgu gcacucacua      840

agcgucauuc cugauagugg guacaucucu gaggugcgga auuuucagga aaccauucau      900

caacucgagg gacgccuggu acgacaggac caccagauca gagaacuuac ugcaaaaaug      960

gagacacagu ccauguaugu uagcgagcug aagaggacca uccggacguu ggaagauaag     1020

guggcugaga uugaagccca acagugcaac ggcauauaca ucuggaaaau uggcaacuuc     1080

gggaugcauc ucaagugcca ggaggaagag aaaccagucg ugauccacuc gcccggauuu     1140

uauacuggua agccuggcua caaacugugu augcguuuac aucugcagcu cccaaccgcg     1200

caacgcugcg ccaauuacau aucucuuuuc gugcacacaa ugcaggggga guaugacucc     1260

caucugcccu ggccguucca gggaacuauu agauugacca uccuagauca gucagaagca     1320

ccugucaggc aaaaccacga ggaaaucaug gacgcuaagc ccgagcugcu cgccuuucag     1380

cggccaacaa uuccucgaaa ucccaaaggc uucgguuacg uuaccuuuau gcaccuggag     1440

gcucuuaggc agagaacguu caucaaggau gacacucugu uggugaggug ugaaguaagu     1500

acacgguuug auauggggag ccuccgcaga gagggauucc agccaagguc caccgacgcc     1560

ggcguguga                                                             1569


<210>  9849
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       TRAF6__Homo_sapiens__AAB38751

<400>  9849
augagccugc ugaacugcga gaacagcugc ggcagcagcc agagcgagag cgacugcugc       60

guggccaugg ccagcagcug cagcgccgug accaaggacg acagcguggg cggcaccgcc      120

agcaccggca accugagcag cagcuucaug gaggagaucc agggcuacga cguggaguuc      180

gacccccccc uggagagcaa guacgagugc cccaucugcc ugauggcccu gagagaggcc      240

gugcagaccc ccugcggcca cagauucugc aaggccugca ucaucaagag caucagagac      300

gccggccaca agugccccgu ggacaacgag auccugcugg agaaccagcu guuccccgac      360

aacuucgcca agagagagau ccugagccug auggugaagu gccccaacga gggcugccug      420

cacaagaugg agcugagaca ccuggaggac caccaggccc acugcgaguu cgcccugaug      480

gacugccccc agugccagag acccuuccag aaguuccaca ucaacaucca cauccugaag      540

gacugcccca gaagacaggu gagcugcgac aacugcgccg ccagcauggc cuucgaggac      600

aaggagaucc acgaccagaa cugcccccug gccaacguga ucugcgagua cugcaacacc      660

auccugauca gagagcagau gcccaaccac uacgaccugg acugccccac cgcccccauc      720

cccugcaccu ucagcaccuu cggcugccac gagaagaugc agagaaacca ccuggccaga      780

caccugcagg agaacaccca gagccacaug agaaugcugg cccaggccgu gcacagccug      840

agcgugaucc ccgacagcgg cuacaucagc gaggugagaa acuuccagga gaccauccac      900

cagcuggagg gcagacuggu gagacaggac caccagauca gagagcugac cgccaagaug      960

gagacccaga gcauguacgu gagcgagcug aagagaacca ucagaacccu ggaggacaag     1020

guggccgaga ucgaggccca gcagugcaac ggcaucuaca ucuggaagau cggcaacuuc     1080

ggcaugcacc ugaagugcca ggaggaggag aagcccgugg ugauccacag ccccggcuuc     1140

uacaccggca agcccggcua caagcugugc augagacugc accugcagcu gcccaccgcc     1200

cagagaugcg ccaacuacau cagccuguuc gugcacacca ugcagggcga guacgacagc     1260

caccugcccu ggcccuucca gggcaccauc agacugacca uccuggacca gagcgaggcc     1320

cccgugagac agaaccacga ggagaucaug gacgccaagc ccgagcugcu ggccuuccag     1380

agacccacca uccccagaaa ccccaagggc uucggcuacg ugaccuucau gcaccuggag     1440

gcccugagac agagaaccuu caucaaggac gacacccugc uggugagaug cgaggugagc     1500

accagauucg acaugggcag ccugagaaga gagggcuucc agcccagaag caccgacgcc     1560

ggcguguga                                                             1569


<210>  9850
<211>  1569
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       TRAF6__Homo_sapiens__AAB38751

<400>  9850
augagccugc ucaacugcga gaauagcugu ggcucuagcc aguccgaauc ugacugcugu       60

guggccaugg cuagcuccug cucugccguc accaaggaug acagcguugg gggaacagcg      120

uccacgggca accuguccuc uuccuucaug gaggaaaucc aaggguacga uguggaguuu      180

gaucccccuc uugaaagcaa auaugagugu ccgauuugcc ugauggcucu cagagaggcc      240

gugcagaccc ccuguggaca ccgguucugc aaggccugua ucauuaaauc uauccgcgac      300

gcuggccaua agugcccugu cgacaaugaa auucugcuug agaaccagcu guuucccgau      360

aauuucgcca aaagagaaau ccucucccug auggugaagu guccuaacga ggggugccug      420

cacaagaugg agcuccggca ucuggaagac caccaggcuc auugcgaguu ugcccuuaug      480

gauugucccc aaugccagcg cccuuuccag aaauuucaca ucaauauuca cauccugaag      540

gacuguccga gacggcaggu uagcugcgau aacugugcgg ccucuauggc uuucgaagac      600

aaagagauuc augaucaaaa uugcccccuc gccaacguga ucugugaaua cugcaauaca      660

auucugaucc gcgagcagau gccuaaccac uaugaccuug acugucccac cgcuccuauu      720

cccugcacau uuuccaccuu cggaugucau gagaagaugc agagaaauca ccuggcccgg      780

caccuccagg aaaacacaca aagccauaug cgcaugcugg cgcaggccgu ccacucccug      840

ucugugaucc cggauagcgg cuacaucucc gagguuagaa auuuucagga aaccauucau      900

caacucgagg gccggcuggu gcgccaggac caccagauca gagaacuuac ggcuaaaaug      960

gagacccaga gcauguaugu cucugagcug aagcggacaa uucgcacccu cgaagauaag     1020

guggccgaga ucgaagcuca acagugcaac gggauuuaca ucuggaaaau cggaaacuuc     1080

ggcaugcauc ugaagugcca ggaggaagag aaaccugugg ucauucacuc ccccggguuu     1140

uauacaggaa agccuggcua caaacuuugu augagacugc accuccagcu gcccaccgcc     1200

caacggugcg ccaauuacau cagccuguuc guucauacga ugcaggggga guaugacucu     1260

caccuccccu ggccuuucca gggaacaauu agacugacca uccuugauca gagcgaagcu     1320

ccggugcgcc aaaaccauga ggaaauuaug gacgcgaagc ccgagcugcu cgccuuucag     1380

cggccuacaa uccccagaaa uccuaaaggc uucggcuacg ugaccuuuau gcaccuggag     1440

gcccuucgcc agcggaccuu caucaaggau gacacacugc ucgucagaug ugaagugucc     1500

acgcgcuuug auaugggguc ucugcggaga gagggauucc agccccgcag caccgacgcu     1560

ggcguuuga                                                             1569


<210>  9851
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__A0A0B4J1R1

<400>  9851

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Gly Gly Thr Arg 
                245                 250                 255     


Arg 
    


<210>  9852
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__EAW92099

<400>  9852
augccccuca acguuagcuu caccaacagg aacuaugacc ucgacuacga cucggugcag       60

ccguauuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagcccccgg cgcccagcga ggauaucugg aagaaauucg agcugcugcc caccccgccc      180

cuguccccua gccgccgcuc cgggcucugc ucgcccuccu acguugcggu cacacccuuc      240

ucccuucggg gagacaacga cggcgguggc gggagcuucu ccacggccga ccagcuggag      300

auggugaccg agcugcuggg aggagacaug gugaaccaga guuucaucug cgacccggac      360

gacgagaccu ucaucaaaaa caucaucauc caggacugua uguggagcgg cuucucggcc      420

gccgccaagc ucgucucaga gaagcuggcc uccuaccagg cugcgcgcaa agacagcggc      480

agcccgaacc ccgcccgcgg ccacagcguc ugcuccaccu ccagcuugua ccugcaggau      540

cugagcgccg ccgccucaga gugcaucgac cccucggugg ucuuccccua cccucucaac      600

gacagcagcu cgcccaaguc cugcgccucg caagacucca gcgccuucuc uccguccucg      660

gauucucugc ucuccucgac ggaguccucc ccgcagggca gccccgagcc ccuggugcuc      720

caugaggaga caccgcccac caccagcagc gacucuggag gaacaagaag auga            774


<210>  9853
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-myc__Homo_sapiens__EAW92099

<400>  9853
augccccuga acgugagcuu caccaaccgc aacuacgacc ucgacuacga cuccguccag       60

cccuacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagccgcccg cccccuccga ggacaucugg aagaaguucg agcugcuccc gaccccgccc      180

cugagccccu cccggcgcag cggccugugc ucccccagcu acguggccgu gacgcccuuc      240

ucccuccgcg gggacaacga cggcgggggc gggagcuucu ccaccgcgga ccagcuggag      300

auggucaccg agcugcucgg cggcgacaug gugaaccaga gcuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca ugugguccgg guucagcgcc      420

gccgccaagc ugguguccga gaagcuggcc agcuaccagg cggcccggaa ggacuccggc      480

agccccaacc cggcccgggg gcacuccguc ugcagcacga gcucccucua ccugcaggac      540

cugagcgccg cggccuccga gugcaucgac cccagcgugg uguuccccua cccccucaac      600

gacuccagcu cccccaagag cugcgccucc caggacagcu ccgccuucag ccccuccagc      660

gacucccugc ugagcuccac cgagagcagc ccccagggcu cccccgagcc gcucguccug      720

cacgaggaga ccccgcccac cacgagcucc gacagcgggg gcacccgccg guga            774


<210>  9854
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-myc__Homo_sapiens__EAW92099

<400>  9854
augccccuca acgucuccuu caccaaccgc aacuacgacc ucgacuacga cuccguccag       60

cccuacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca guccgagcuc      120

cagccccccg cccccuccga ggacaucugg aagaaguucg agcuccuccc cacccccccc      180

cucucccccu cccgccgcuc cggccucugc ucccccuccu acgucgccgu cacccccuuc      240

ucccuccgcg gcgacaacga cggcggcggc ggcuccuucu ccaccgccga ccagcucgag      300

auggucaccg agcuccucgg cggcgacaug gucaaccagu ccuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca ugugguccgg cuucuccgcc      420

gccgccaagc ucgucuccga gaagcucgcc uccuaccagg ccgcccgcaa ggacuccggc      480

ucccccaacc ccgcccgcgg ccacuccguc ugcuccaccu ccucccucua ccuccaggac      540

cucuccgccg ccgccuccga gugcaucgac cccuccgucg ucuuccccua cccccucaac      600

gacuccuccu cccccaaguc cugcgccucc caggacuccu ccgccuucuc ccccuccucc      660

gacucccucc ucuccuccac cgaguccucc ccccagggcu cccccgagcc ccucguccuc      720

cacgaggaga ccccccccac caccuccucc gacuccggcg gcacccgccg cuga            774


<210>  9855
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-myc__Homo_sapiens__EAW92099

<400>  9855
augccccuga acgugagcuu caccaauaga aacuacgacc ucgauuauga cuccguccag       60

ccuuacuuuu auugcgauga ggaagagaau uucuaccaac agcagcagca aucugaacuu      120

cagccaccgg cccccucaga ggacaucugg aagaaauuug aacuguugcc uacaccaccc      180

uuaaguccua gcaggcgguc cggccugugu ucuccaucgu auguugcugu gacucccuuc      240

ucacuacgcg gggauaacga cggagguggc gggagcuuua guacggcaga ucagcucgag      300

augguaaccg agcugcuugg aggcgacaug gugaaucagu ccuucauuug cgauccugac      360

gaugaaacau uuauaaagaa caucauuauc caagacugua uguggucugg uuucagcgcc      420

gcggcuaaac uggucuccga gaaguuggcc ucauaccagg cagcccgaaa agauaguggg      480

agcccaaauc cggcucgugg acacucugug ugcuccacuu caagccucua ucugcaggac      540

cugagugcag ccgcuucuga auguauugac cccuccguug uguuuccuua cccacucaac      600

gauagcucgu cucccaaguc cugcgccuca caggacagua gcgcguucuc cccuucuagc      660

gauucauuac ugaguuccac cgagagcucu ccacaaggcu cacccgagcc gcuugucuug      720

caugaagaga caccucccac cacaaguagc gacuccggcg ggacuagaag guga            774


<210>  9856
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-myc__Homo_sapiens__EAW92099

<400>  9856
augccccuga acgugagcuu caccaacaga aacuacgacc uggacuacga cagcgugcag       60

cccuacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagccccccg cccccagcga ggacaucugg aagaaguucg agcugcugcc cacccccccc      180

cugagcccca gcagaagaag cggccugugc agccccagcu acguggccgu gacccccuuc      240

agccugagag gcgacaacga cggcggcggc ggcagcuuca gcaccgccga ccagcuggag      300

auggugaccg agcugcuggg cggcgacaug gugaaccaga gcuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca uguggagcgg cuucagcgcc      420

gccgccaagc uggugagcga gaagcuggcc agcuaccagg ccgccagaaa ggacagcggc      480

agccccaacc ccgccagagg ccacagcgug ugcagcacca gcagccugua ccugcaggac      540

cugagcgccg ccgccagcga gugcaucgac cccagcgugg uguuccccua cccccugaac      600

gacagcagca gccccaagag cugcgccagc caggacagca gcgccuucag ccccagcagc      660

gacagccugc ugagcagcac cgagagcagc ccccagggca gccccgagcc ccuggugcug      720

cacgaggaga ccccccccac caccagcagc gacagcggcg gcaccagaag auga            774


<210>  9857
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-myc__Homo_sapiens__EAW92099

<400>  9857
augccccuga acgugagcuu caccaauaga aacuacgacc ucgauuauga cuccguccag       60

ccuuacuuuu auugcgauga ggaagagaau uucuaccaac agcagcagca aucugaacug      120

cagccgcccg ccccuagcga ggacaucugg aagaaauuug aacuucugcc cacaccuccc      180

cucuccccuu cucggcgcag cggccugugu uccccgucuu auguugcugu gacgcccuuc      240

agccuuagag gggauaacga cggaggcggg ggauccuuua gcaccgccga ucagcuggag      300

auggugacag agcuccuggg cggggacaug gucaaucagu cuuucauuug cgauccugac      360

gaugaaaccu uuaucaagaa cauuaucauu caagacugua ugugguccgg auucagcgcg      420

gcugccaaac uggugucuga gaagcucgcc uccuaccagg cugcccggaa agauagcggc      480

ucucccaauc cugcucgcgg ccacuccguu ugcagcacau ccucucugua ucuucaggac      540

cugagcgccg cggccuccga auguaucgac cccagcgugg ucuuuccgua cccucucaac      600

gauucuucca gccccaaguc uugcgcuagc caggacuccu cugccuucag cccuuccagc      660

gauucucugc uuuccagcac cgagucuagc ccccaagggu cccccgagcc ucuggugcuc      720

caugaagaga caccgcccac cacguccucu gacagcggag gcaccagacg guga            774


<210>  9858
<211>  774
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       c-myc__Homo_sapiens__EAW92099

<400>  9858
augccacuaa acguaucuuu cacaaauaga aacuacgacc uagacuacga cucaguacaa       60

ccauacuuuu acugcgacga agaagaaaac uucuaccaac aacaacaaca aucagaacua      120

caaccacccg caccauccga agacaucugg aaaaaauucg aauuacuacc aacaccaccc      180

uuaucaccau caagaagauc aggacuaugu ucaccauccu acguagcugu aacaccauuc      240

ucacuaagag gagacaacga uggaggagga ggaucauucu caacagcaga ccaacuagaa      300

augguaacag aacuacucgg aggcgacaug guaaaucaau cauucauaug cgaccccgac      360

gaugaaacau ucaucaaaaa uaucauaaua caagacugca uguggucagg auucucagca      420

gcugcaaaac ucguaucaga aaaacuagcc ucauaccaag cagcaagaaa agacucagga      480

ucaccaaacc cagcaagagg acacucagua ugcucaacau caucauuaua ccuacaagac      540

uuaucagcag cagcaucaga augcauagac ccaucagucg uauucccaua cccacuaaac      600

gacucaucuu caccuaaauc cugcgcauca caagauucau cagcauucuc accaucauca      660

gacucacuac uaucaucaac agaaucauca ccccaaggcu caccagaacc auuaguauua      720

cacgaagaaa caccaccaac aaccucaucu gacucuggag gaacaagaag auaa            774


<210>  9859
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__P01106

<400>  9859

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  9860
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__AAA36340

<400>  9860
augccccuca acguuagcuu caccaacagg aacuaugacc ucgacuacga cucggugcag       60

ccguauuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagcccccgg cgcccagcga ggauaucugg aagaaauucg agcugcugcc caccccgccc      180

cuguccccua gccgccgcuc cgggcucugc ucgcccuccu acguugcggu cacacccuuc      240

ucccuucggg gagacaacga cggcgguggc gggagcuucu ccacggccga ccagcuggag      300

auggugaccg agcugcuggg aggagacaug gugaaccaga guuucaucug cgacccggac      360

gacgagaccu ucaucaaaaa caucaucauc caggacugua uguggagcgg cuucucggcc      420

gccgccaagc ucgucucaga gaagcuggcc uccuaccagg cugcgcgcaa agacagcggc      480

agcccgaacc ccgcccgcgg ccacagcguc ugcuccaccu ccagcuugua ccugcaggau      540

cugagcgccg ccgccucaga gugcaucgac cccucggugg ucuuccccua cccucucaac      600

gacagcagcu cgcccaaguc cugcgccucg caagacucca gcgccuucuc uccguccucg      660

gauucucugc ucuccucgac ggaguccucc ccgcagggca gccccgagcc ccuggugcuc      720

caugaggaga caccgcccac caccagcagc gacucugagg aggaacaaga agaugaggaa      780

gaaaucgaug uuguuucugu ggaaaagagg caggcuccug gcaaaagguc agagucugga      840

ucaccuucug cuggaggcca cagcaaaccu ccucacagcc cacugguccu caagaggugc      900

cacgucucca cacaucagca caacuacgca gcgccucccu ccacucggaa ggacuauccu      960

gcugccaaga gggucaaguu ggacaguguc agaguccuga gacagaucag caacaaccga     1020

aaaugcacca gccccagguc cucggacacc gaggagaaug ucaagaggcg aacacacaac     1080

gucuuggagc gccagaggag gaacgagcua aaacggagcu uuuuugcccu gcgugaccag     1140

aucccggagu uggaaaacaa ugaaaaggcc cccaagguag uuauccuuaa aaaagccaca     1200

gcauacaucc uguccgucca agcagaggag caaaagcuca uuucugaaga ggacuuguug     1260

cggaaacgac gagaacaguu gaaacacaaa cuugaacagc uacggaacuc uugugcguaa     1320


<210>  9861
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-myc__Homo_sapiens__AAA36340

<400>  9861
augccccuga acgugagcuu caccaaccgc aacuacgacc ucgacuacga cuccguccag       60

ccguacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagccgcccg cccccuccga ggacaucugg aagaaguucg agcugcuccc gaccccgccc      180

cugagccccu cccggcgcag cggccugugc ucccccagcu acguggccgu gacgcccuuc      240

ucccuccgcg gggacaacga cggcgggggc gggagcuucu ccaccgcgga ccagcuggag      300

auggucaccg agcugcucgg cggcgacaug gugaaccaga gcuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca ugugguccgg guucagcgcc      420

gccgccaagc ugguguccga gaagcuggcc agcuaccagg cggcccggaa ggacuccggc      480

agccccaacc cggcccgggg gcacuccguc ugcagcacga gcucccucua ccugcaggac      540

cugagcgccg cggccuccga gugcaucgac cccagcgugg uguuccccua cccccucaac      600

gacuccagcu cccccaagag cugcgccucc caggacagcu ccgccuucag ccccuccagc      660

gacucccugc ugagcuccac cgagagcagc ccccagggcu cccccgagcc gcucguccug      720

cacgaggaga ccccgcccac cacgagcucc gacagcgagg aggagcagga ggacgaggag      780

gagaucgacg ugguguccgu cgagaagcgc caggcccccg ggaagcggag cgaguccggc      840

agccccuccg cgggcgggca cagcaagccg ccccacagcc cccuggugcu caagcgcugc      900

cacgugucca cccaccagca caacuacgcc gccccgcccu ccacccggaa ggacuacccc      960

gccgccaagc gcgucaagcu ggacagcgug cgggugcugc gccagaucuc caacaaccgg     1020

aagugcacca gcccccgcuc cagcgacacg gaggagaacg ucaagcggcg cacccacaac     1080

gugcucgagc ggcagcgccg gaacgagcug aagcgcuccu ucuucgcgcu gcgggaccag     1140

auccccgagc ucgagaacaa cgagaaggcc cccaaggugg ucauccugaa gaaggccacc     1200

gccuacaucc ugagcgugca ggccgaggag cagaagcuca ucagcgagga ggaccugcug     1260

cgcaagcgcc gggagcagcu caagcacaag cuggagcagc ugcgcaacuc cugcgcguga     1320


<210>  9862
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-myc__Homo_sapiens__AAA36340

<400>  9862
augccccuca acgucuccuu caccaaccgc aacuacgacc ucgacuacga cuccguccag       60

cccuacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca guccgagcuc      120

cagccccccg cccccuccga ggacaucugg aagaaguucg agcuccuccc cacccccccc      180

cucucccccu cccgccgcuc cggccucugc ucccccuccu acgucgccgu cacccccuuc      240

ucccuccgcg gcgacaacga cggcggcggc ggcuccuucu ccaccgccga ccagcucgag      300

auggucaccg agcuccucgg cggcgacaug gucaaccagu ccuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca ugugguccgg cuucuccgcc      420

gccgccaagc ucgucuccga gaagcucgcc uccuaccagg ccgcccgcaa ggacuccggc      480

ucccccaacc ccgcccgcgg ccacuccguc ugcuccaccu ccucccucua ccuccaggac      540

cucuccgccg ccgccuccga gugcaucgac cccuccgucg ucuuccccua cccccucaac      600

gacuccuccu cccccaaguc cugcgccucc caggacuccu ccgccuucuc ccccuccucc      660

gacucccucc ucuccuccac cgaguccucc ccccagggcu cccccgagcc ccucguccuc      720

cacgaggaga ccccccccac caccuccucc gacuccgagg aggagcagga ggacgaggag      780

gagaucgacg ucgucuccgu cgagaagcgc caggcccccg gcaagcgcuc cgaguccggc      840

ucccccuccg ccggcggcca cuccaagccc ccccacuccc cccucguccu caagcgcugc      900

cacgucucca cccaccagca caacuacgcc gccccccccu ccacccgcaa ggacuacccc      960

gccgccaagc gcgucaagcu cgacuccguc cgcguccucc gccagaucuc caacaaccgc     1020

aagugcaccu ccccccgcuc cuccgacacc gaggagaacg ucaagcgccg cacccacaac     1080

guccucgagc gccagcgccg caacgagcuc aagcgcuccu ucuucgcccu ccgcgaccag     1140

auccccgagc ucgagaacaa cgagaaggcc cccaaggucg ucauccucaa gaaggccacc     1200

gccuacaucc ucuccgucca ggccgaggag cagaagcuca ucuccgagga ggaccuccuc     1260

cgcaagcgcc gcgagcagcu caagcacaag cucgagcagc uccgcaacuc cugcgccuga     1320


<210>  9863
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-myc__Homo_sapiens__AAA36340

<400>  9863
augccccuga acgugagcuu caccaauaga aacuacgacc ucgauuauga cuccguccag       60

ccuuacuuuu auugcgauga ggaagagaau uucuaccaac agcagcagca aucugaacuu      120

cagccaccgg cccccucaga ggacaucugg aagaaauuug aacuguugcc uacaccaccc      180

uuaaguccua gcaggcgguc cggccugugu ucuccaucgu auguugcugu gacucccuuc      240

ucacuacgcg gggauaacga cggagguggc gggagcuuua guacggcaga ucagcucgag      300

augguaaccg agcugcuugg aggcgacaug gugaaucagu ccuucauuug cgauccugac      360

gaugaaacau uuauaaagaa caucauuauc caagacugua uguggucugg uuucagcgcc      420

gcggcuaaac uggucuccga gaaguuggcc ucauaccagg cagcccgaaa agauaguggg      480

agcccaaauc cggcucgugg acacucugug ugcuccacuu caagccucua ucugcaggac      540

cugagugcag ccgcuucuga auguauugac cccuccguug uguuuccuua cccacucaac      600

gauagcucgu cucccaaguc cugcgccuca caggacagua gcgcguucuc cccuucuagc      660

gauucauuac ugaguuccac cgagagcucu ccacaaggcu cacccgagcc gcuugucuug      720

caugaagaga caccucccac cacaaguagc gacuccgaag aggaacagga ggaugaggaa      780

gagaucgacg ugguaucugu ugaaaagaga caggcaccag gcaaaagguc ggagagcggg      840

uccccuucag ccggagguca caguaagccc ccacauucuc cccuggugcu aaaacggugu      900

cacgucagca cucaucaaca caauuacgcu gccccuccau ccacccgcaa ggauuauccg      960

gcagcuaaaa gagugaagcu cgacucagug aggguccugc ggcagauaag caacaaucgc     1020

aagugcacgu cuccccgauc cagugauacu gaagagaacg uuaaaagaag gacccacaau     1080

gugcuugagc ggcagcgucg caacgaacug aagaggagcu uuuucgccuu gagagaccag     1140

aucccugagc ucgaaaauaa cgagaaagcg ccaaagguag ugauucugaa aaaggccaca     1200

gcauacaucu uaucugucca agcugaggaa cagaaacuga uuuccgagga agaucuccuu     1260

cggaagcgac gcgagcagcu gaagcauaaa uuggaacagc uaagaaacuc augugccuga     1320


<210>  9864
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-myc__Homo_sapiens__AAA36340

<400>  9864
augccccuga acgugagcuu caccaacaga aacuacgacc uggacuacga cagcgugcag       60

cccuacuucu acugcgacga ggaggagaac uucuaccagc agcagcagca gagcgagcug      120

cagccccccg cccccagcga ggacaucugg aagaaguucg agcugcugcc cacccccccc      180

cugagcccca gcagaagaag cggccugugc agccccagcu acguggccgu gacccccuuc      240

agccugagag gcgacaacga cggcggcggc ggcagcuuca gcaccgccga ccagcuggag      300

auggugaccg agcugcuggg cggcgacaug gugaaccaga gcuucaucug cgaccccgac      360

gacgagaccu ucaucaagaa caucaucauc caggacugca uguggagcgg cuucagcgcc      420

gccgccaagc uggugagcga gaagcuggcc agcuaccagg ccgccagaaa ggacagcggc      480

agccccaacc ccgccagagg ccacagcgug ugcagcacca gcagccugua ccugcaggac      540

cugagcgccg ccgccagcga gugcaucgac cccagcgugg uguuccccua cccccugaac      600

gacagcagca gccccaagag cugcgccagc caggacagca gcgccuucag ccccagcagc      660

gacagccugc ugagcagcac cgagagcagc ccccagggca gccccgagcc ccuggugcug      720

cacgaggaga ccccccccac caccagcagc gacagcgagg aggagcagga ggacgaggag      780

gagaucgacg uggugagcgu ggagaagaga caggcccccg gcaagagaag cgagagcggc      840

agccccagcg ccggcggcca cagcaagccc ccccacagcc cccuggugcu gaagagaugc      900

cacgugagca cccaccagca caacuacgcc gcccccccca gcaccagaaa ggacuacccc      960

gccgccaaga gagugaagcu ggacagcgug agagugcuga gacagaucag caacaacaga     1020

aagugcacca gccccagaag cagcgacacc gaggagaacg ugaagagaag aacccacaac     1080

gugcuggaga gacagagaag aaacgagcug aagagaagcu ucuucgcccu gagagaccag     1140

auccccgagc uggagaacaa cgagaaggcc cccaaggugg ugauccugaa gaaggccacc     1200

gccuacaucc ugagcgugca ggccgaggag cagaagcuga ucagcgagga ggaccugcug     1260

agaaagagaa gagagcagcu gaagcacaag cuggagcagc ugagaaacag cugcgccuga     1320


<210>  9865
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-myc__Homo_sapiens__AAA36340

<400>  9865
augccccuga acgugagcuu caccaauaga aacuacgacc ucgauuauga cuccguccag       60

ccuuacuuuu auugcgauga ggaagagaau uucuaccaac agcagcagca aucugaacug      120

cagccgcccg ccccuagcga ggacaucugg aagaaauuug aacuucugcc cacaccuccc      180

cucuccccuu cucggcgcag cggccugugu uccccgucuu auguugcugu gacgcccuuc      240

agccuuagag gggauaacga cggaggcggg ggauccuuua gcaccgccga ucagcuggag      300

auggugacag agcuccuggg cggggacaug gucaaucagu cuuucauuug cgauccugac      360

gaugaaaccu uuaucaagaa cauuaucauu caagacugua ugugguccgg auucagcgcg      420

gcugccaaac uggugucuga gaagcucgcc uccuaccagg cugcccggaa agauagcggc      480

ucucccaauc cugcucgcgg ccacuccguu ugcagcacau ccucucugua ucuucaggac      540

cugagcgccg cggccuccga auguaucgac cccagcgugg ucuuuccgua cccucucaac      600

gauucuucca gccccaaguc uugcgcuagc caggacuccu cugccuucag cccuuccagc      660

gauucucugc uuuccagcac cgagucuagc ccccaaggga gccccgagcc ucuggugcuc      720

caugaagaga caccgcccac cacguccucu gacagcgaag aggaacagga ggaugaggaa      780

gagaucgacg uuguguccgu cgaaaagaga caggcuccug gaaaacgguc ugagagcggc      840

ucccccagcg ccgggggaca cucuaagccu ccccauuccc cgcuggugcu gaaacgcugu      900

cacgugagca cccaucaaca caauuacgcg gccccucccu cuacaagaaa ggauuauccu      960

gcugccaaac gggucaagcu cgacuccguu cgcgugcuga gacagauuag caacaaucgg     1020

aagugcaccu cuccccgcag cuccgauaca gaagagaacg ugaaaagacg gacccacaau     1080

guccuugagc gccagagacg gaacgaacug aagagauccu uuuucgcucu ccgcgaccag     1140

aucccugagc uggaaaauaa cgagaaagcc cccaaggugg uuauucuuaa aaaggccacg     1200

gcuuacaucc ugucugugca agcggaggaa cagaaacuca uuuccgagga agaucugcug     1260

cggaagagac gcgagcagcu caagcauaaa cuggaacagc uucggaacag cugugccuga     1320


<210>  9866
<211>  1320
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       c-myc__Homo_sapiens__AAA36340

<400>  9866
augccauuaa acgucucuuu cacaaacaga aauuacgacc uagacuacga uucaguacaa       60

ccauauuuuu acugcgacga agaagaaaac uucuaucaac aacaacaaca aucagaacuc      120

caaccaccag cucccucuga agacaucugg aaaaaauucg aacuauuacc aacaccacca      180

uuaucuccuu cacgaagauc aggucuaugc ucaccaucau acguagccgu uaccccauuc      240

ucauuacgug gcgauaacga uggaggcgga ggaucauucu caacagcuga ucaauuagaa      300

auggucacag aacuacucgg aggugauaug guuaaucaaa gcuucauuug ugauccagau      360

gacgaaacau ucauaaaaaa cauuauaaua caagauugca uguggucagg auucucagca      420

gcagcaaaau uaguaucaga aaaacuagcu ucauaucaag cagcaagaaa agauuccggc      480

ucaccaaacc ccgcacgagg acauucagua ugcagcaccu caucauuaua cuuacaagac      540

cucucagcug cagcaucaga augcauagac ccauccguag uauuuccaua cccacuuaac      600

gauucuucau caccaaaauc augcgcaucc caagauucaa gugcauucuc accgucauca      660

gacucauuac ucucauccac agaaucuagc ccucaaggau caccagaacc auuaguauua      720

caugaagaaa caccaccaac aacaucauca gacuccgaag aagaacaaga agacgaagaa      780

gaaauugacg uaguuucagu agaaaaaaga caagcacccg gaaaacgauc agaaucaggu      840

ucacccucag caggaggcca cagcaaacca ccacacucac cacuaguauu aaaaagaugc      900

cacguaucaa cacaccaaca caacuacgca gcaccaccau caacaagaaa agauuacccu      960

gcagcaaaaa gagucaaacu agacucaguc agaguauuac gccaaauauc aaauaauaga     1020

aaaugcacau caccaagauc auccgacaca gaagaaaacg uaaaacgacg aacacauaac     1080

guacuagaaa gacaaagaag aaacgaacua aaacgauccu ucuucgcauu acgagaccaa     1140

auccccgaac uagaaaacaa cgaaaaagca ccaaaaguag uuauucuaaa aaaagcaaca     1200

gcuuacauac ucucaguaca agccgaagaa caaaaauuaa ucucugaaga agaucuacuc     1260

agaaaaagac gcgaacaacu aaaacacaaa cuagaacaac uaagaaauuc augcgcauaa     1320


<210>  9867
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__Q14901

<400>  9867

Met Arg Gly Ser Gly Arg Leu Arg Thr Pro Glu Leu Val Cys Ser Arg 
1               5                   10                  15      


Pro Pro Pro Pro Gly Pro Gly Arg Pro Trp Leu Pro Ser Cys Leu Glu 
            20                  25                  30          


Lys Gly Arg Ala Ser Gln Arg Leu Gly Gly Lys Lys Asn Gly Gly Arg 
        35                  40                  45              


Asp Arg Ala Glu Tyr Lys Ser Arg Phe Ser Gly Leu Tyr Leu Thr Arg 
    50                  55                  60                  


Cys Ser Asn Ser Ser Glu Arg Gln Arg Glu Arg Ala Gly Gly Arg Leu 
65                  70                  75                  80  


Gly Trp Lys Ser Arg Ala Ser Arg Ala Ala Leu Arg Ala Ser Trp Glu 
                85                  90                  95      


Gly Arg Ser Gly Ala Asn Arg Gly Leu Arg Leu Trp Pro Ser Pro Pro 
            100                 105                 110         


Ala Asp Pro Pro Ala Ser Arg Pro Gln Pro Leu Pro His Pro Arg Asn 
        115                 120                 125             


Phe Ala His Ser Ser Gly Arg Ala Leu Cys Thr Gly Thr Tyr Asn Thr 
    130                 135                 140                 


Arg Ala Arg Thr Arg Leu Ser Arg Arg Gly Glu Ala Ile Leu Pro Ile 
145                 150                 155                 160 


Trp Gly His Phe Pro Ala Ala Ala Arg Thr Arg Phe Ser Glu Arg Leu 
                165                 170                 175     


Ser Leu Gln Leu Leu Arg Arg Trp Ile Phe Phe Gly 
            180                 185             


<210>  9868
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__AAA59886

<400>  9868
augcgagggu cuggacggcu gaggaccccc gagcuggucu gcucgcggcc gccaccgccg       60

ggccccggcc gucccuggcu ccccuccugc cucgagaagg gcagggcuuc ucagaggcuu      120

ggcgggaaaa agaacggagg gagggaucgc gcugaguaua aaagccgguu uucggggcuu      180

uaucuaacuc gcuguaguaa uuccagcgag aggcagaggg agcgagcggg cggccggcua      240

ggguggaaga gccgggcgag cagagcugcg cugcgggcgu ccugggaagg gagauccgga      300

gcgaauaggg ggcuucgccu cuggcccagc ccucccgcug aucccccagc cagccguccg      360

caacccuugc cgcauccacg aaacuuugcc cauagcagcg ggcgggcacu uugcacugga      420

acuuacaaca cccgagcaag gacgcgacuc ucccgacgcg gggaggcuau ucugcccauu      480

uggggacacu uccccgccgc ugccaggacc cgcuucucug aaaggcucuc cuugcagcug      540

cuuagacgcu ggauuuuuuu cggguag                                          567


<210>  9869
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-myc__Homo_sapiens__AAA59886

<400>  9869
augcgcggca gcgggcggcu gcgcaccccc gagcucgugu gcucccggcc gcccccgccc       60

ggccccgggc gccccuggcu gcccagcugc cuggagaagg gccgggccuc ccagcgccuc      120

gggggcaaga agaacggcgg gcgggaccgc gccgaguaca agagccgguu cuccggccug      180

uaccugaccc gcugcagcaa cuccagcgag cggcagcgcg agcgggccgg gggccgccuc      240

ggguggaagu cccgggcgag ccgcgccgcc cugcgggccu ccugggaggg ccgcagcggc      300

gcgaaccggg ggcugcgccu cuggcccucc ccgcccgccg acccgcccgc cagccggccc      360

cagccccugc cccacccccg caacuucgcc cacuccagcg gccgcgcgcu gugcacgggg      420

accuacaaca cccgggcccg cacccggcuc ucccgccggg gcgaggccau ccugccgauc      480

uggggccacu uccccgccgc cgcgcgcacg cgguucagcg agcgccuguc ccuccagcug      540

cugcggcgcu ggaucuucuu cggguga                                          567


<210>  9870
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-myc__Homo_sapiens__AAA59886

<400>  9870
augcgcggcu ccggccgccu ccgcaccccc gagcucgucu gcucccgccc cccccccccc       60

ggccccggcc gccccuggcu ccccuccugc cucgagaagg gccgcgccuc ccagcgccuc      120

ggcggcaaga agaacggcgg ccgcgaccgc gccgaguaca agucccgcuu cuccggccuc      180

uaccucaccc gcugcuccaa cuccuccgag cgccagcgcg agcgcgccgg cggccgccuc      240

ggcuggaagu cccgcgccuc ccgcgccgcc cuccgcgccu ccugggaggg ccgcuccggc      300

gccaaccgcg gccuccgccu cuggcccucc ccccccgccg acccccccgc cucccgcccc      360

cagccccucc cccacccccg caacuucgcc cacuccuccg gccgcgcccu cugcaccggc      420

accuacaaca cccgcgcccg cacccgccuc ucccgccgcg gcgaggccau ccuccccauc      480

uggggccacu uccccgccgc cgcccgcacc cgcuucuccg agcgccucuc ccuccagcuc      540

cuccgccgcu ggaucuucuu cggcuga                                          567


<210>  9871
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-myc__Homo_sapiens__AAA59886

<400>  9871
augagaggca gcgggaggcu gcggaccccc gagcucgugu gcucccgccc uccaccgccc       60

ggaccugguc gaccauggcu ucccucuugu cuggaaaagg gccgugccuc acagagauug      120

ggagggaaaa agaacggcgg uagggaccgg gcugaguaca aaagucgcuu cagcggguua      180

uaucugacaa gaugcuccaa uucuucggaa aggcaacggg agcgcgcagg aggccgacua      240

ggcuggaagu caagagccag cagggcggcu cuccgggcca guugggaagg gcguuccgga      300

gcaaaccgcg gucugagacu uuggccuucu ccacccgccg auccuccagc uagcaggccg      360

cagccccugc cucacccacg gaauuuugca cauuccucag gccgagccuu guguacuggg      420

acguacaaca cccgcgcuag aacaaggcuc agucggcgcg gagaggccau ccugcccauu      480

uggggccacu ucccugcggc agccagaacu agguuuagcg agcgucuguc ucuccaguua      540

cugcggcgau ggauauucuu ugguuga                                          567


<210>  9872
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-myc__Homo_sapiens__AAA59886

<400>  9872
augagaggca gcggcagacu gagaaccccc gagcuggugu gcagcagacc cccccccccc       60

ggccccggca gacccuggcu gcccagcugc cuggagaagg gcagagccag ccagagacug      120

ggcggcaaga agaacggcgg cagagacaga gccgaguaca agagcagauu cagcggccug      180

uaccugacca gaugcagcaa cagcagcgag agacagagag agagagccgg cggcagacug      240

ggcuggaaga gcagagccag cagagccgcc cugagagcca gcugggaggg cagaagcggc      300

gccaacagag gccugagacu guggcccagc ccccccgccg acccccccgc cagcagaccc      360

cagccccugc cccaccccag aaacuucgcc cacagcagcg gcagagcccu gugcaccggc      420

accuacaaca ccagagccag aaccagacug agcagaagag gcgaggccau ccugcccauc      480

uggggccacu uccccgccgc cgccagaacc agauucagcg agagacugag ccugcagcug      540

cugagaagau ggaucuucuu cggcuga                                          567


<210>  9873
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-myc__Homo_sapiens__AAA59886

<400>  9873
augagaggca gcgggcggcu gcgcaccccc gagcucgugu gcuccagacc uccgcccccu       60

ggacccggcc ggccuuggcu gcccucuugu cuugaaaagg ggcgcgccag ccagagacug      120

ggaggcaaga agaacggggg acgggaccgc gcugaguaca aauccagauu cucuggccuc      180

uaucugacac ggugcagcaa uuccucugaa cgccaaagag agcgggccgg cgggcgccuu      240

ggauggaaaa gcagagcguc ccgggcugcc cugcgcgcca gcugggaagg cagaucuggg      300

gcuaaccggg gacucagacu guggccuucc ccgcccgccg auccucccgc uagccgcccu      360

cagccccugc cgcacccucg gaauuuugcc cauucuuccg gcagagcgcu cuguacgggg      420

accuacaaca cacgcgcccg gaccagacug agccgccggg gagaggcuau ccuucccauu      480

uggggccacu ucccugccgc ugccagaaca cgcuuuucug agcggcuguc ccuccagcug      540

cuuagacgcu ggaucuucuu uggcuga                                          567


<210>  9874
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       c-myc__Homo_sapiens__AAA59886

<400>  9874
augagaggua guggaagauu aagaacacca gaauuaguau guagcagacc accaccacca       60

ggaccaggaa gaccaugguu accaagcugu uuagaaaaag gaagagcaag ccagagacua      120

ggaggaaaaa aaaauggagg aagagauaga gcugaauaua aaaguagauu uucaggacua      180

uauuuaacaa gauguaguaa caguucagaa agacaaagag aaagagcagg aggaagauua      240

ggauggaaau caagagcauc aagggcagca uuaagagcau caugggaagg aaggagugga      300

gcaaaucgag gauuaagauu auggccauca ccaccagcag auccaccagc uaguagacca      360

caaccgcuac cacauccaag aaauuuugca cauucaagcg gaagagcacu auguacugga      420

acauauaaua caagagcaag aacaagauua aguagaagag gagaagcaau acuaccaaua      480

uggggacauu uuccagcagc agcaaggaca cgauuuagug aaagauuaag uuuacaacua      540

uuaagaagau ggauauuuuu uggauaa                                          567


<210>  9875
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__Q16591

<400>  9875

Met Arg Gly Ser Gly Arg Leu Arg Thr Pro Glu Leu Cys Cys Ser Arg 
1               5                   10                  15      


Pro Pro Pro Pro Gly Pro Gly Arg Pro Trp Leu Pro Ser Cys Leu Glu 
            20                  25                  30          


Lys Gly Arg Ala Ser Gln Arg Leu Gly Gly Lys Lys Asn Gly Gly Arg 
        35                  40                  45              


Asp Arg Ala Glu Tyr Lys Ser Arg Phe Ser Gly Leu Tyr Leu Thr Arg 
    50                  55                  60                  


Cys Ser Asn Ser Ser Glu Arg Gln Arg Glu Arg Ala Gly Gly Arg Leu 
65                  70                  75                  80  


Gly Trp Lys Ser Arg Ala Ser Arg Ala Ala Leu Arg Ala Ser Trp Glu 
                85                  90                  95      


Gly Arg Ser Gly Ala Asn Arg Gly Leu Arg Leu Trp Pro Ser Pro Pro 
            100                 105                 110         


Ala Asp Pro Pro Ala Ser Gly Pro Gln Pro Leu Pro His Pro Arg Asn 
        115                 120                 125             


Phe Ala His Ser Ser Gly Arg Ala Leu Cys Thr Gly Thr Tyr Asn Thr 
    130                 135                 140                 


Arg Ala Arg Thr Arg Leu Ser Arg Arg Gly Glu Ala Ile Leu Pro Ile 
145                 150                 155                 160 


Trp Gly His Phe Pro Ala Ala Ala Arg Thr Arg Phe Ser Glu Arg Leu 
                165                 170                 175     


Ser Leu Gln Leu Leu Arg Arg Trp Ile Phe Phe Gly 
            180                 185             


<210>  9876
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  c-myc__Homo_sapiens__AAA59887

<400>  9876
augcgagggu cuggacggcu gaggaccccc gagcugugcu gcucgcggcc gccaccgccg       60

ggccccggcc gucccuggcu ccccuccugc cucgagaagg gcagggcuuc ucagaggcuu      120

ggcgggaaaa agaacggagg gagggaucgc gcugaguaua aaagccgguu uucggggcuu      180

uaucuaacuc gcuguaguaa uuccagcgag aggcagaggg agcgagcggg cggccggcua      240

ggguggaaga gccgggcgag cagagcugcg cugcgggcgu ccugggaagg gagauccgga      300

gcgaauaggg ggcuucgccu cuggcccagc ccucccgcug aucccccagc cagcgguccg      360

caacccuugc cgcauccacg aaacuuugcc cauagcagcg ggcgggcacu uugcacugga      420

acuuacaaca cccgagcaag gacgcgacuc ucccgacgcg gggaggcuau ucugcccauu      480

uggggacacu uccccgccgc ugccaggacc cgcuucucug aaaggcucuc cuugcagcug      540

cuuagacgcu ggauuuuuuu cggguag                                          567


<210>  9877
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       c-myc__Homo_sapiens__AAA59887

<400>  9877
augcgcggca gcgggcggcu gcgcaccccc gagcucugcu gcucccggcc gcccccgccc       60

ggccccgggc gccccuggcu gcccagcugc cuggagaagg gccgggccuc ccagcgccuc      120

gggggcaaga agaacggcgg gcgggaccgc gccgaguaca agagccgguu cuccggccug      180

uaccugaccc gcugcagcaa cuccagcgag cggcagcgcg agcgggccgg gggccgccuc      240

ggguggaagu cccgggcgag ccgcgccgcc cugcgggccu ccugggaggg ccgcagcggc      300

gcgaaccggg ggcugcgccu cuggcccucc ccgcccgccg acccgcccgc cagcggcccc      360

cagccccugc cccacccccg gaacuucgcc cacuccagcg ggcgcgcgcu gugcacgggc      420

accuacaaca cccgcgcccg gacccgccuc ucccggcgcg gcgaggccau ccugccgauc      480

ugggggcacu uccccgccgc cgcgcggacg cgcuucagcg agcggcuguc ccuccagcug      540

cugcgccggu ggaucuucuu cggcuga                                          567


<210>  9878
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       c-myc__Homo_sapiens__AAA59887

<400>  9878
augcgcggcu ccggccgccu ccgcaccccc gagcucugcu gcucccgccc cccccccccc       60

ggccccggcc gccccuggcu ccccuccugc cucgagaagg gccgcgccuc ccagcgccuc      120

ggcggcaaga agaacggcgg ccgcgaccgc gccgaguaca agucccgcuu cuccggccuc      180

uaccucaccc gcugcuccaa cuccuccgag cgccagcgcg agcgcgccgg cggccgccuc      240

ggcuggaagu cccgcgccuc ccgcgccgcc cuccgcgccu ccugggaggg ccgcuccggc      300

gccaaccgcg gccuccgccu cuggcccucc ccccccgccg acccccccgc cuccggcccc      360

cagccccucc cccacccccg caacuucgcc cacuccuccg gccgcgcccu cugcaccggc      420

accuacaaca cccgcgcccg cacccgccuc ucccgccgcg gcgaggccau ccuccccauc      480

uggggccacu uccccgccgc cgcccgcacc cgcuucuccg agcgccucuc ccuccagcuc      540

cuccgccgcu ggaucuucuu cggcuga                                          567


<210>  9879
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       c-myc__Homo_sapiens__AAA59887

<400>  9879
augagaggca gcgggaggcu gcggaccccc gagcucugcu guucccgccc uccaccgccc       60

ggaccugguc gaccauggcu ucccucuugc cuggaaaagg gccgugccuc acagagauug      120

ggagggaaaa agaacggcgg uagggaccgg gcugaguaca aaagucgcuu cagcggguua      180

uaucugacaa gauguuccaa uucuucggaa aggcaacggg agcgcgcagg aggccgacua      240

ggcuggaagu caagagccag cagggcggcu cuccgggcca guugggaagg gcguuccgga      300

gcaaaccgcg gucugagacu uuggccuucu ccacccgccg auccuccagc uagcggcccg      360

cagccccugc cucacccaag gaauuuugca cauuccucag ggcgggccuu gugcacugga      420

acguacaaca cccgagcucg cacaagacuc aguaggcggg gcgaggccau ccugcccauu      480

uggggucacu ucccugcggc agcccgcacu agauuuagcg agaggcuguc ucuccaguua      540

cugcgucggu ggauauucuu uggguga                                          567


<210>  9880
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       c-myc__Homo_sapiens__AAA59887

<400>  9880
augagaggca gcggcagacu gagaaccccc gagcugugcu gcagcagacc cccccccccc       60

ggccccggca gacccuggcu gcccagcugc cuggagaagg gcagagccag ccagagacug      120

ggcggcaaga agaacggcgg cagagacaga gccgaguaca agagcagauu cagcggccug      180

uaccugacca gaugcagcaa cagcagcgag agacagagag agagagccgg cggcagacug      240

ggcuggaaga gcagagccag cagagccgcc cugagagcca gcugggaggg cagaagcggc      300

gccaacagag gccugagacu guggcccagc ccccccgccg acccccccgc cagcggcccc      360

cagccccugc cccaccccag aaacuucgcc cacagcagcg gcagagcccu gugcaccggc      420

accuacaaca ccagagccag aaccagacug agcagaagag gcgaggccau ccugcccauc      480

uggggccacu uccccgccgc cgccagaacc agauucagcg agagacugag ccugcagcug      540

cugagaagau ggaucuucuu cggcuga                                          567


<210>  9881
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       c-myc__Homo_sapiens__AAA59887

<400>  9881
augagaggca gcgggcggcu gcgcaccccc gagcucugcu guuccagacc uccgcccccu       60

ggacccggcc ggccuuggcu gcccucuugc cuugaaaagg ggcgcgccag ccagagacug      120

ggaggcaaga agaacggggg acgggaccgc gcugaguaca aauccagauu cucuggccuc      180

uaucugacac gguguagcaa uuccucugaa cgccaaagag agcgggccgg cgggcgccuu      240

ggauggaaaa gcagagcguc ccgggcugcc cugcgcgcca gcugggaagg cagaucuggg      300

gcuaaccggg gacucagacu guggccuucc ccgcccgccg auccucccgc uagcggcccu      360

cagccccugc cgcacccucg caauuuugcc cauucuuccg ggcgggcgcu cugcacggga      420

accuacaaca caagagcccg cacccggcug agcagacgcg gcgaggcuau ccuucccauu      480

uggggccacu ucccugccgc ugcccggaca agauuuucug agcgccuguc ccuccagcug      540

cuucggagau ggaucuucuu uggguga                                          567


<210>  9882
<211>  567
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       c-myc__Homo_sapiens__AAA59887

<400>  9882
augagaggau caggaagacu aagaacacca gaauuaugcu guaguagacc accaccacca       60

ggaccaggaa gaccaugguu accaaguugu uuagaaaaag gaagagcgag ucaaagauua      120

ggaggaaaaa aaaauggagg aagagacaga gcagaauaua aaagcagauu uucagguuua      180

uauuuaacaa gauguucaaa uucaagugaa agacaaagag aaagagcagg aggaagacua      240

ggauggaaau caagagcaag uagagcagca uuaagagcau cgugggaagg aagaagugga      300

gcaaauagag gauuaagauu auggccauca ccaccagcgg auccaccagc aucaggacca      360

caaccauuac cacauccaag aaauuuugca cauaguagug gaagagcauu auguacagga      420

acauauaaua caagagcgag aacaagauua agcagaagag gagaagcaau auuaccuaua      480

uggggacacu uuccagcagc agcaagaaca agauuuagug aaagacuaag uuuacaauua      540

uuaagaagau ggauauuuuu ugguuaa                                          567


<210>  9883
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf1__Homo_sapiens__K7VKE0

<400>  9883

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Leu Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Ser Gly Ala Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Arg Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Arg 
                165                 170                 175     


Arg Arg Leu Leu Gly Trp Leu Leu Pro Ala Asp Arg Ala Phe Ser Ala 
            180                 185                 190         


Cys Gly Val Gly Arg Pro Leu Arg Ala Thr Val Arg Val Pro Arg Asp 
        195                 200                 205             


Val Pro Gly Ala Ser Val Pro Arg Ala Leu Pro Ala Leu Pro Arg Ala 
    210                 215                 220                 


Pro Gly Thr Arg Ala Arg Ser Arg His Val Pro Leu Leu Pro Glu Leu 
225                 230                 235                 240 


Phe Gly Thr Arg Asp Gly Gly His Trp Thr Arg Gly Asp Cys Arg Gly 
                245                 250                 255     


Ser Arg Cys Asp Ser Arg Asp Arg Ala Ile Gln Ala Arg Pro Thr Phe 
            260                 265                 270         


Val Gly Ala Gln Glu Ala Gly Ser Ala His Val Arg Ala Pro Gly Leu 
        275                 280                 285             


Arg Gln Glu Leu His Gln Glu Leu Pro Pro Glu Gly Ala Ser Ala His 
    290                 295                 300                 


Ala His Arg Gly Glu Ala Ile Arg Leu His Val Gly Arg Leu Arg Leu 
305                 310                 315                 320 


Glu Ile Arg Ala Leu Gly Arg Ala Asp Pro Pro Leu Pro Glu Thr His 
                325                 330                 335     


Gly Ala Ala Pro Leu Pro Leu Pro Ala Leu Pro Thr Cys Phe Phe Ala 
            340                 345                 350         


Leu 
    


<210>  9884
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf1__Homo_sapiens__AFW90650

<400>  9884
auggccacag ccgagaccgc cuugcccucc aucagcacac ugaccgcccu gggccccuuc       60

ccggacacac aggaugacuu ccucaagugg uggcgcuccg aagaggcgca ggacaugggc      120

ccggguccuc cugaccccac ggagccgccc cuccacguga agucugagga ccagcccggg      180

gaggaagagg acgaugagag gggcgcggac gccaccuggg accuggaucu ccuccucacc      240

aacuucucgg gcccggagcc cgguggcgcg ccccagaccu gcgcucuggc gcccagcgag      300

gccuccgggg cgcaauaucc gccgccgccc gagacucugg gcgcauaugc uggcggcccg      360

gggcuggugg cugggcuuuu ggguucggag gaucacucgg guugggugcg cccugcccug      420

cgagcccggg cucccgacgc cuucgugggc ccagcccugg cuccagcccc ggcccccgag      480

cccaaggcgc uggcgcugca accgguguac ccggggcccg gcgcccggcg ccggcuccuc      540

ggguggcuac uucccgcgga ccgggcuuuc agugccugcg gcgucgggcg cccccuacgg      600

gcuacugucc ggguaccccg cgauguaccc ggcgccucag uaccaagggc acuuccagcu      660

cuuccgcggg cuccagggac ccgcgcccgg ucccgccacg ucccccuccu uccugaguug      720

uuugggaccc gggacggugg gcacuggacu cggggggacu gcagaggauc caggugugau      780

agccgagacc gcgccaucca agcgaggccg acguucgugg gcgcgcaaga ggcaggcagc      840

gcacacgugc gcgcacccgg guugcggcaa gagcuacacc aagagcuccc accugaaggc      900

gcaucugcgc acgcacacag gggagaagcc auacgccugc acgugggaag gcugcggcug      960

gagauucgcg cgcucggacg agcugacccg ccacuaccgg aaacacacgg ggcagcgccc     1020

cuuccgcugc cagcucugcc cacgugcuuu uucgcgcucu ga                        1062


<210>  9885
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf1__Homo_sapiens__AFW90650

<400>  9885
auggccaccg ccgagaccgc gcugcccagc aucuccacgc ucaccgcccu gggccccuuc       60

cccgacaccc aggacgacuu ccugaagugg uggcgcagcg aggaggccca ggacaugggg      120

cccgggcccc cggaccccac cgagccgccc cuccacguga aguccgagga ccagcccggg      180

gaggaggagg acgacgagcg gggcgccgac gccacguggg accuggaccu gcuccugacc      240

aacuucagcg ggcccgagcc cggcggcgcg ccccagaccu gcgcccuggc cccguccgag      300

gccagcgggg cgcaguaccc gcccccgccc gagacccucg gcgccuacgc cgggggcccc      360

gggcuggucg ccggccugcu cggcuccgag gaccacagcg ggugggugcg ccccgcccug      420

cgggcgcgcg cccccgacgc cuucgugggc cccgcccugg cccccgcgcc cgcccccgag      480

ccgaaggccc ucgcccugca gcccgucuac cccgggcccg gcgcccggcg ccggcugcuc      540

ggcuggcugc ugccggcgga ccgcgccuuc uccgccugcg gggugggccg gccccuccgc      600

gccacggugc gggucccccg cgacgugccg ggggccagcg ugccccgggc gcugcccgcc      660

cugccccgcg ccccgggcac ccgggcccgc ucccggcacg ucccccuccu gcccgagcug      720

uucgggaccc gcgacggcgg ccacuggacc cggggcgacu gccgcggcag ccggugcgac      780

ucccgcgacc gcgcgaucca ggcccggccc acguucgugg gggcccagga ggccggcagc      840

gcccacgugc gcgcgccggg gcuccggcag gagcugcacc aggagcugcc gcccgagggc      900

gccuccgccc acgcccaccg cggcgaggcc auccggcucc acgucgggcg ccugcggcug      960

gagauccgcg cgcucggccg ggccgacccg ccccugcccg agacccacgg ggccgcgccc     1020

cugccccucc ccgcccugcc gaccugcuuc uucgcccugu ga                        1062


<210>  9886
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf1__Homo_sapiens__AFW90650

<400>  9886
auggccaccg ccgagaccgc ccuccccucc aucuccaccc ucaccgcccu cggccccuuc       60

cccgacaccc aggacgacuu ccucaagugg uggcgcuccg aggaggccca ggacaugggc      120

cccggccccc ccgaccccac cgagcccccc cuccacguca aguccgagga ccagcccggc      180

gaggaggagg acgacgagcg cggcgccgac gccaccuggg accucgaccu ccuccucacc      240

aacuucuccg gccccgagcc cggcggcgcc ccccagaccu gcgcccucgc ccccuccgag      300

gccuccggcg cccaguaccc cccccccccc gagacccucg gcgccuacgc cggcggcccc      360

ggccucgucg ccggccuccu cggcuccgag gaccacuccg gcuggguccg ccccgcccuc      420

cgcgcccgcg cccccgacgc cuucgucggc cccgcccucg cccccgcccc cgcccccgag      480

cccaaggccc ucgcccucca gcccgucuac cccggccccg gcgcccgccg ccgccuccuc      540

ggcuggcucc uccccgccga ccgcgccuuc uccgccugcg gcgucggccg cccccuccgc      600

gccaccgucc gcgucccccg cgacgucccc ggcgccuccg ucccccgcgc ccuccccgcc      660

cucccccgcg cccccggcac ccgcgcccgc ucccgccacg ucccccuccu ccccgagcuc      720

uucggcaccc gcgacggcgg ccacuggacc cgcggcgacu gccgcggcuc ccgcugcgac      780

ucccgcgacc gcgccaucca ggcccgcccc accuucgucg gcgcccagga ggccggcucc      840

gcccacgucc gcgcccccgg ccuccgccag gagcuccacc aggagcuccc ccccgagggc      900

gccuccgccc acgcccaccg cggcgaggcc auccgccucc acgucggccg ccuccgccuc      960

gagauccgcg cccucggccg cgccgacccc ccccuccccg agacccacgg cgccgccccc     1020

cucccccucc ccgcccuccc caccugcuuc uucgcccucu ga                        1062


<210>  9887
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf1__Homo_sapiens__AFW90650

<400>  9887
auggccaccg cugagacagc acugcccagc aucuccacuc ucacggcccu uggcccuuuc       60

ccagacaccc aggaugacuu ucugaagugg uggagaucug aagaggcgca agauaugggg      120

ccgggacccc cugacccaac agaacccccu uugcacguga aaucagagga ucagccaggu      180

gaagaggagg acgaugaaag gggcgcugac gccacuuggg auuuagaccu gcuacucacc      240

aacuucagug ggcccgagcc uggaggcgca ccacagacau gcgcccuggc uccgagcgaa      300

gcauccggug cccaguaucc cccuccaccc gagacccuug gggcuuacgc cggaggcccu      360

ggccuggucg cgggguugcu cggaucugag gaucauucgg guuggguucg gccagcacug      420

cgcgcccgag cucccgacgc cuuugugggc ccggcacugg cuccugcccc cgcgccagaa      480

ccuaaggccc ucgcauuaca acccguauac ccagggcccg gagcucguag aaggcugcuu      540

ggcugguugc ugccugccga ucgggcuuuc ucagccugug guguggggcg cccacuaaga      600

gcaacuguca gggugccgcg ggacguuccc ggagccagcg ugccucgcgc ucucccagcg      660

cugccccgag caccuggcac aagagccagg agucggcacg ucccacuucu gcccgaguug      720

uuuggcaccc gugacggggg acauuggacg cgcggugauu gcagaggcuc caggugugac      780

ucucgggauc gagcuauuca ggcccgcccg acuuucgugg gggcacagga agccggaagc      840

gcucacguaa gagccccugg ccucaggcag gagcugcauc aagaauuacc acccgagggu      900

gcauccgcgc acgcucaccg cggggaggcc auacggcugc auguuggcag acucaggcuu      960

gaaauccgug cacugggacg ggccgacccu cccuugccag agacccacgg cgcugccccu     1020

cuaccccugc cagcacuccc gacaugcuuu uucgcucugu ga                        1062


<210>  9888
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf1__Homo_sapiens__AFW90650

<400>  9888
auggccaccg ccgagaccgc ccugcccagc aucagcaccc ugaccgcccu gggccccuuc       60

cccgacaccc aggacgacuu ccugaagugg uggagaagcg aggaggccca ggacaugggc      120

cccggccccc ccgaccccac cgagcccccc cugcacguga agagcgagga ccagcccggc      180

gaggaggagg acgacgagag aggcgccgac gccaccuggg accuggaccu gcugcugacc      240

aacuucagcg gccccgagcc cggcggcgcc ccccagaccu gcgcccuggc ccccagcgag      300

gccagcggcg cccaguaccc cccccccccc gagacccugg gcgccuacgc cggcggcccc      360

ggccuggugg ccggccugcu gggcagcgag gaccacagcg gcugggugag acccgcccug      420

agagccagag cccccgacgc cuucgugggc cccgcccugg cccccgcccc cgcccccgag      480

cccaaggccc uggcccugca gcccguguac cccggccccg gcgccagaag aagacugcug      540

ggcuggcugc ugcccgccga cagagccuuc agcgccugcg gcgugggcag accccugaga      600

gccaccguga gagugcccag agacgugccc ggcgccagcg ugcccagagc ccugcccgcc      660

cugcccagag cccccggcac cagagccaga agcagacacg ugccccugcu gcccgagcug      720

uucggcacca gagacggcgg ccacuggacc agaggcgacu gcagaggcag cagaugcgac      780

agcagagaca gagccaucca ggccagaccc accuucgugg gcgcccagga ggccggcagc      840

gcccacguga gagcccccgg ccugagacag gagcugcacc aggagcugcc ccccgagggc      900

gccagcgccc acgcccacag aggcgaggcc aucagacugc acgugggcag acugagacug      960

gagaucagag cccugggcag agccgacccc ccccugcccg agacccacgg cgccgccccc     1020

cugccccugc ccgcccugcc caccugcuuc uucgcccugu ga                        1062


<210>  9889
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf1__Homo_sapiens__AFW90650

<400>  9889
auggccaccg cugagacagc ccugcccagc aucuccacgc ucaccgcgcu gggcccuuuc       60

ccggacacac aggacgacuu ucuuaagugg uggagaucug aagaggcuca agauaugggg      120

cccggaccuc ccgacccuac cgaacccccu cugcacguga aaagcgagga ucagccgggc      180

gaagaggagg acgaugaacg gggagccgac gccacauggg aucucgaccu gcuucugacc      240

aacuucuccg gacccgagcc uggcggggcu ccccagacau gcgcccucgc uccuucugaa      300

gccagcggag cgcaguaucc cccgccuccc gagacccugg gcgccuacgc uggcgggccu      360

ggacuggucg ccggccuccu gggguccgag gaucauucug gauggguucg ccccgcucuu      420

agagcccggg cgcccgacgc cuuugugggc ccugcucugg ccccggcucc cgccccugaa      480

cccaaggccc ucgcucugca accuguguac cccgggccgg gagcgcgcag acggcuucug      540

ggcuggcucc ugccugccga ucgcgcuuuc agcgccugug gcgucgggag accccugcgg      600

gccacggugc gcguuccuag agacgugccc ggagcuuccg ucccucgggc ccuccccgcg      660

cugccgcgcg cuccuggcac cagagcccgg agccgccacg ugccccuucu gcccgagcuc      720

uuugggacaa gagacggagg ccauuggacc agaggggauu gccggggauc ucgcugugac      780

ucccgggaua gagccauuca ggcucgcccu acauucguug gcgcccagga agcuggcagc      840

gcccacgugc gggcgccggg gcugagacag gagcuucauc aagaacugcc cccugaggga      900

gccucugcuc acgcccaccg cggcgaggcu auccggcucc augucgggag acugcgccug      960

gaaauucggg cccucgggag agcggauccc ccucugcccg agacccacgg cgccgcuccu     1020

cuuccccugc cggcccuccc uacgugcuuu uucgcucugu ga                        1062


<210>  9890
<211>  1062
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf1__Homo_sapiens__AFW90650

<400>  9890
auggcaacag cugaaacugc acuaccaucu auauccacuu uaacagcauu aggaccauuc       60

ccagacacac aagaugauuu uuuaaaaugg uggagaucag aagaagcaca agauauggga      120

ccuggaccac ccgaucccac agaaccuccu cuacauguaa aaucagaaga ccaaccagga      180

gaagaagaag augacgaaag aggagcagac gcaacauggg auuuagacuu auuacuaacu      240

aauuucucag gaccagaacc agguggugca ccacaaacau gugcauuggc accaucagaa      300

gcaucaggag cacaauaccc accaccacca gaaacacuag gagcauacgc uggaggaccu      360

ggauuaguag cuggauuguu aggaucagaa gaccauucag gauggguuag acccgcacuu      420

agagcucgag caccagaugc cuuuguagga ccugcacuug caccagcacc agcaccugaa      480

ccaaaagcac uagcauuaca accaguguau ccaggaccag gagcaagaag acgauuauua      540

ggaugguuau uaccagcaga uagagcauuu ucagcaugug gagugggaag gccuuuaaga      600

gcuacuguaa gaguaccaag agacguacca ggagcaucag uaccaagagc auuaccagca      660

uuaccuagag caccuggcac aagagcaaga agucgucaug uaccauuauu accagaauua      720

uuugguacaa gagauggugg acacuggaca agaggagauu guagaggauc cagaugugau      780

ucacgagaua gagcgaucca agcaagaccu acauuuguag gugcacaaga agcuggaagc      840

gcgcauguaa gagcacccgg uuuaagacaa gaauuacauc aagaauuacc accagaagga      900

gcaucagcac augcacauag aggugaagca auaagauuac auguaggaag auuacgauua      960

gaaauaagag cacuagguag agcugacccu ccauuaccag aaacacaugg ggcagcaccu     1020

uuaccacuac cagcacuacc aacuuguuuu uuugcacuuu aa                        1062


<210>  9891
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf1__Homo_sapiens__Q13351

<400>  9891

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Leu Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Ser Gly Ala Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Arg Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Gly 
                165                 170                 175     


Ser Ser Gly Gly Tyr Phe Pro Arg Thr Gly Leu Ser Val Pro Ala Ala 
            180                 185                 190         


Ser Gly Ala Pro Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Met Tyr Pro 
        195                 200                 205             


Ala Pro Gln Tyr Gln Gly His Phe Gln Leu Phe Arg Gly Leu Gln Gly 
    210                 215                 220                 


Pro Ala Pro Gly Pro Ala Thr Ser Pro Ser Phe Leu Ser Cys Leu Gly 
225                 230                 235                 240 


Pro Gly Thr Val Gly Thr Gly Leu Gly Gly Thr Ala Glu Asp Pro Gly 
                245                 250                 255     


Val Ile Ala Glu Thr Ala Pro Ser Lys Arg Gly Arg Arg Ser Trp Ala 
            260                 265                 270         


Arg Lys Arg Gln Ala Ala His Thr Cys Ala His Pro Gly Cys Gly Lys 
        275                 280                 285             


Ser Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Ala Cys Thr Trp Glu Gly Cys Gly Trp Arg Phe 
305                 310                 315                 320 


Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Gln 
                325                 330                 335     


Arg Pro Phe Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp 
            340                 345                 350         


His Leu Ala Leu His Met Lys Arg His Leu 
        355                 360         


<210>  9892
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf1__Homo_sapiens__AAB51173

<400>  9892
auggccacag ccgagaccgc cuugcccucc aucagcacac ugaccgcccu gggccccuuc       60

ccggacacac aggaugacuu ccucaagugg uggcgcuccg aagaggcgca ggacaugggc      120

ccggguccuc cugaccccac ggagccgccc cuccacguga agucugagga ccagcccggg      180

gaggaagagg acgaugagag gggcgcggac gccaccuggg accuggaucu ccuccucacc      240

aacuucucgg gcccggagcc cgguggcgcg ccccagaccu gcgcucuggc gcccagcgag      300

gccuccgggg cgcaauaucc gccgccgccc gagacucugg gcgcauaugc uggcggcccg      360

gggcuggugg cugggcuuuu ggguucggag gaucacucgg guugggugcg cccugcccug      420

cgagcccggg cucccgacgc cuucgugggc ccagcccugg cuccagcccc ggcccccgag      480

cccaaggcgc uggcgcugca accgguguac ccggggcccg gcgccggcuc cucggguggc      540

uacuucccgc ggaccgggcu uucagugccu gcggcgucgg gcgcccccua cgggcuacug      600

uccggguacc ccgcgaugua cccggcgccu caguaccaag ggcacuucca gcucuuccgc      660

gggcuccagg gacccgcgcc cggucccgcc acgucccccu ccuuccugag uuguuuggga      720

cccgggacgg ugggcacugg acucgggggg acugcagagg auccaggugu gauagccgag      780

accgcgccau ccaagcgagg ccgacguucg ugggcgcgca agaggcaggc agcgcacacg      840

ugcgcgcacc cggguugcgg caagagcuac accaagagcu cccaccugaa ggcgcaucug      900

cgcacgcaca caggggagaa gccauacgcc ugcacguggg aaggcugcgg cuggagauuc      960

gcgcgcucgg acgagcugac ccgccacuac cggaaacaca cggggcagcg ccccuuccgc     1020

ugccagcucu gcccacgugc uuuuucgcgc ucugaccacc uggccuugca caugaagcgc     1080

caccuuuga                                                             1089


<210>  9893
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf1__Homo_sapiens__AAB51173

<400>  9893
auggccaccg ccgagaccgc gcugcccagc aucuccacgc ucaccgcccu gggcccguuc       60

cccgacaccc aggacgacuu ccugaagugg uggcgcagcg aggaggccca ggacaugggg      120

cccgggcccc cggaccccac cgagccgccc cuccacguga aguccgagga ccagcccggc      180

gaggaggagg acgacgagcg gggcgccgac gccacguggg accuggaccu gcuccugacc      240

aacuucagcg ggcccgagcc cggcggcgcg ccccagaccu gcgcccuggc cccguccgag      300

gccagcgggg cgcaguaccc gcccccgccc gagacccucg gcgccuacgc cgggggcccc      360

gggcuggucg ccggccugcu cggcuccgag gaccacagcg ggugggugcg ccccgcccug      420

cgggcgcgcg cccccgacgc cuucgugggc cccgcccugg cccccgcgcc cgcccccgag      480

ccgaaggccc ucgcccugca gcccgucuac cccgggcccg gcgccggcuc cagcgggggc      540

uacuucccgc ggacggggcu guccgugccc gcggccagcg gcgcccccua cgggcuccug      600

uccggcuacc cggccaugua ccccgcgccc caguaccagg gccacuucca gcuguuccgc      660

gggcuccagg gccccgcccc ggggcccgcc accagccccu ccuuccugag cugccugggc      720

cccgggaccg ugggcaccgg ccucgggggc acggccgagg acccgggggu caucgccgag      780

accgcgcccu ccaagcgggg ccgccggagc ugggcccgca agcggcaggc cgcccacacg      840

ugcgcccacc ccgggugcgg caaguccuac accaagagca gccaccugaa ggcgcaccuc      900

cgcacccaca ccggcgagaa gcccuacgcc ugcaccuggg aggggugcgg cuggcgguuc      960

gcccgcuccg acgagcugac ccggcacuac cgcaagcaca cggggcagcg gccguuccgc     1020

ugccagcugu gcccccgggc cuucagccgc uccgaccacc uggcccucca caugaagcgg     1080

caccuguga                                                             1089


<210>  9894
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf1__Homo_sapiens__AAB51173

<400>  9894
auggccaccg ccgagaccgc ccuccccucc aucuccaccc ucaccgcccu cggccccuuc       60

cccgacaccc aggacgacuu ccucaagugg uggcgcuccg aggaggccca ggacaugggc      120

cccggccccc ccgaccccac cgagcccccc cuccacguca aguccgagga ccagcccggc      180

gaggaggagg acgacgagcg cggcgccgac gccaccuggg accucgaccu ccuccucacc      240

aacuucuccg gccccgagcc cggcggcgcc ccccagaccu gcgcccucgc ccccuccgag      300

gccuccggcg cccaguaccc cccccccccc gagacccucg gcgccuacgc cggcggcccc      360

ggccucgucg ccggccuccu cggcuccgag gaccacuccg gcuggguccg ccccgcccuc      420

cgcgcccgcg cccccgacgc cuucgucggc cccgcccucg cccccgcccc cgcccccgag      480

cccaaggccc ucgcccucca gcccgucuac cccggccccg gcgccggcuc cuccggcggc      540

uacuuccccc gcaccggccu cuccgucccc gccgccuccg gcgcccccua cggccuccuc      600

uccggcuacc ccgccaugua ccccgccccc caguaccagg gccacuucca gcucuuccgc      660

ggccuccagg gccccgcccc cggccccgcc accucccccu ccuuccucuc cugccucggc      720

cccggcaccg ucggcaccgg ccucggcggc accgccgagg accccggcgu caucgccgag      780

accgcccccu ccaagcgcgg ccgccgcucc ugggcccgca agcgccaggc cgcccacacc      840

ugcgcccacc ccggcugcgg caaguccuac accaaguccu cccaccucaa ggcccaccuc      900

cgcacccaca ccggcgagaa gcccuacgcc ugcaccuggg agggcugcgg cuggcgcuuc      960

gcccgcuccg acgagcucac ccgccacuac cgcaagcaca ccggccagcg ccccuuccgc     1020

ugccagcucu gcccccgcgc cuucucccgc uccgaccacc ucgcccucca caugaagcgc     1080

caccucuga                                                             1089


<210>  9895
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf1__Homo_sapiens__AAB51173

<400>  9895
auggccaccg cugagacagc acugcccagc aucuccacuc ucacggcccu uggcccuuuc       60

ccagacaccc aggaugacuu ucugaagugg uggagaucug aagaggcgca agauaugggg      120

ccgggacccc cugacccaac agaacccccu uugcacguga aaucagagga ucagccaggu      180

gaagaggagg acgaugaaag gggcgcugac gccacuuggg auuuagaccu gcuacucacc      240

aacuucagug ggcccgagcc uggaggcgca ccacagacau gcgcccuggc uccgagcgaa      300

gcauccggug cccaguaucc cccuccaccc gagacccuug gggcuuacgc cggaggcccu      360

ggccuggucg cgggguugcu cggaucugag gaucauucgg guuggguucg gccagcacug      420

cgcgcccgag cucccgacgc cuuugugggc ccggcacugg cuccugcccc cgcgccagaa      480

ccuaaggccc ucgcauuaca acccguauac ccagggcccg gagcuggcuc aagcgguggg      540

uauuucccuc guacuggacu gagugugcca gccgcuuccg gcgccccgua cggccuuuug      600

ucuggguauc ccgcaaugua cccugcccca caguaucagg gacacuuuca gcuguucaga      660

ggucuacaag gccccgcucc ugggccagcg acaagccccu ccuuucucuc augucuggga      720

ccgggcaccg ucgguacggg gcuuggcgga acugcagagg auccuggcgu gauugccgaa      780

accgcuccaa guaaaagggg gcggcgcagc ugggccagaa agaggcaggc agcccauaca      840

ugcgcucacc ccggaugugg uaaaucuuac acuaaguccu cacaucugaa ggcccacuug      900

cggacccaca caggcgagaa accuuacgca ugcaccuggg aagggugugg auggcgcuuc      960

gcgcgaagcg acgagcucac gagacauuau aggaagcaca cuggccagcg gcccuuucgu     1020

ugccagcugu guccacgcgc uuucaguaga ucugaccauu uagcccugca caugaaaagg     1080

caccucuga                                                             1089


<210>  9896
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf1__Homo_sapiens__AAB51173

<400>  9896
auggccaccg ccgagaccgc ccugcccagc aucagcaccc ugaccgcccu gggccccuuc       60

cccgacaccc aggacgacuu ccugaagugg uggagaagcg aggaggccca ggacaugggc      120

cccggccccc ccgaccccac cgagcccccc cugcacguga agagcgagga ccagcccggc      180

gaggaggagg acgacgagag aggcgccgac gccaccuggg accuggaccu gcugcugacc      240

aacuucagcg gccccgagcc cggcggcgcc ccccagaccu gcgcccuggc ccccagcgag      300

gccagcggcg cccaguaccc cccccccccc gagacccugg gcgccuacgc cggcggcccc      360

ggccuggugg ccggccugcu gggcagcgag gaccacagcg gcugggugag acccgcccug      420

agagccagag cccccgacgc cuucgugggc cccgcccugg cccccgcccc cgcccccgag      480

cccaaggccc uggcccugca gcccguguac cccggccccg gcgccggcag cagcggcggc      540

uacuucccca gaaccggccu gagcgugccc gccgccagcg gcgcccccua cggccugcug      600

agcggcuacc ccgccaugua ccccgccccc caguaccagg gccacuucca gcuguucaga      660

ggccugcagg gccccgcccc cggccccgcc accagcccca gcuuccugag cugccugggc      720

cccggcaccg ugggcaccgg ccugggcggc accgccgagg accccggcgu gaucgccgag      780

accgccccca gcaagagagg cagaagaagc ugggccagaa agagacaggc cgcccacacc      840

ugcgcccacc ccggcugcgg caagagcuac accaagagca gccaccugaa ggcccaccug      900

agaacccaca ccggcgagaa gcccuacgcc ugcaccuggg agggcugcgg cuggagauuc      960

gccagaagcg acgagcugac cagacacuac agaaagcaca ccggccagag acccuucaga     1020

ugccagcugu gccccagagc cuucagcaga agcgaccacc uggcccugca caugaagaga     1080

caccuguga                                                             1089


<210>  9897
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf1__Homo_sapiens__AAB51173

<400>  9897
auggccaccg cugagacagc ccugcccagc aucuccacgc ucaccgcgcu gggcccuuuc       60

ccggacacac aggaugacuu ucuuaagugg uggagaucug aagaggcuca agauaugggg      120

cccggaccuc ccgacccuac cgaacccccu cugcacguga aaagcgagga ucagccgggc      180

gaagaggagg acgaugaacg cggggccgac gccacauggg aucucgaccu gcuucugacc      240

aacuucuccg gacccgagcc uggcggggcu ccccagacau gcgcccucgc uccuucugaa      300

gccagcggag cgcaguaucc cccgccuccc gagacccugg gcgccuacgc uggcgggccu      360

ggacuggucg ccggccuccu gggguccgag gaucauucug gauggguucg gcccgcucuu      420

agagcccggg cgcccgacgc cuuugugggc ccugcucugg ccccggcucc cgccccugaa      480

cccaaggccc ucgcucugca accuguguac cccgggccgg gagcgggcag cuccggcggg      540

uauuucccuc gcacgggacu uagcgucccc gccgcuucug gcgccccuua cgggcugcuc      600

uccggauauc ccgccaugua cccugcuccc caguaucagg gccacuuuca gcuguucaga      660

gggcugcaag gaccggcccc uggccccgcg accagccccu cuuuucucuc cugucugggc      720

ccugggacag ugggaaccgg ccuuggggga acagcugagg auccgggcgu uauugccgaa      780

accgccccca gcaaacgggg gcgcagaucu ugggcucgga agcgccaggc cgcucauacg      840

ugcgcccacc cuggcugugg aaaauccuac acaaagagcu cccaucugaa ggcgcaccuc      900

agaacccaca caggcgagaa acccuacgcc ugcaccuggg aagggugugg auggcgguuc      960

gcucgcucug acgagcugac cagacauuau cggaagcaca caggccagcg cccuuuuaga     1020

ugccagcuuu guccccgggc cuucagcaga uccgaccauc uggcucucca caugaaacgc     1080

caccuguga                                                             1089


<210>  9898
<211>  1089
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf1__Homo_sapiens__AAB51173

<400>  9898
auggcaacag cagaaacagc acuaccaucu auuucaacac uuacagcauu agguccuuuu       60

ccagauacac aagacgauuu uuuaaaaugg uggagaucag aagaagcuca agauauggga      120

ccaggaccac cagauccaac agaaccuccu cuacauguaa aaucagaaga ucaacccggu      180

gaagaagaag augacgaacg uggagcagac gcaacuuggg aucuugacuu auuauuaacu      240

aauuuuucag gaccagaacc aggaggagca ccacaaacau gcgcauuagc accaagcgaa      300

gcuucaggag cacaauaucc uccaccucca gaaacacucg gagcuuaugc ugguggucca      360

ggauuaguag ccggucuauu agguucagaa gaccauucug guuggguacg accagcauua      420

agagcaaggg caccugaugc auuugucgga ccagcuuuag caccagcucc agcuccagaa      480

ccaaaagcac uagcauuaca accagucuau ccaggccccg gagcaggauc cuccggaggu      540

uacuucccca gaacuggauu aucaguaccc gcugcaucag gagccccaua cggauuauua      600

ucaggauauc cugcaaugua uccagcacca caauaucaag gucacuucca auuauuuagg      660

ggacuucaag gaccugcucc cggaccagca acaucaccau cuuuuuuauc augucuugga      720

ccaggaacag uaggaacagg auuaggugga acagcagaag auccaggagu aauagcagaa      780

acagcaccau cuaaaagagg aagaagauca ugggcacgaa aaagacaagc ugcacauaca      840

ugcgcacauc caggaugugg aaaaucauac acaaaaagcu cacaucuaaa agcacacuug      900

agaacacaua cuggugaaaa accauaugca uguacauggg aaggaugugg uuggagauuc      960

gcaagaucug augaauuaac uagacauuac cgaaaacaua caggucaaag accauucaga     1020

ugccaauuau guccaagagc uuuuuccaga ucagaucauu uagcacucca uaugaaaaga     1080

cauuuauaa                                                             1089


<210>  9899
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf2__Homo_sapiens__Q9Y5W3

<400>  9899

Met Ala Leu Ser Glu Pro Ile Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Pro Cys Arg Glu Arg Gly Leu Gln Glu Arg Trp Pro Arg Ala Glu Pro 
            20                  25                  30          


Glu Ser Gly Gly Thr Asp Asp Asp Leu Asn Ser Val Leu Asp Phe Ile 
        35                  40                  45              


Leu Ser Met Gly Leu Asp Gly Leu Gly Ala Glu Ala Ala Pro Glu Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Pro Ala Phe Tyr Tyr Pro Glu Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Pro Tyr Ser Ala Pro Ala Gly Gly Leu Val Ser Glu Leu Leu 
                85                  90                  95      


Arg Pro Glu Leu Asp Ala Pro Leu Gly Pro Ala Leu His Gly Arg Phe 
            100                 105                 110         


Leu Leu Ala Pro Pro Gly Arg Leu Val Lys Ala Glu Pro Pro Glu Ala 
        115                 120                 125             


Asp Gly Gly Gly Gly Tyr Gly Cys Ala Pro Gly Leu Thr Arg Gly Pro 
    130                 135                 140                 


Arg Gly Leu Lys Arg Glu Gly Ala Pro Gly Pro Ala Ala Ser Cys Met 
145                 150                 155                 160 


Arg Gly Pro Gly Gly Arg Pro Pro Pro Pro Pro Asp Thr Pro Pro Leu 
                165                 170                 175     


Ser Pro Asp Gly Pro Ala Arg Leu Pro Ala Pro Gly Pro Arg Ala Ser 
            180                 185                 190         


Phe Pro Pro Pro Phe Gly Gly Pro Gly Phe Gly Ala Pro Gly Pro Gly 
        195                 200                 205             


Leu His Tyr Ala Pro Pro Ala Pro Pro Ala Phe Gly Leu Phe Asp Asp 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Leu Gly Leu Ala Pro Pro Ala Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Thr Pro Pro Ala Ser Pro Leu Glu Leu Leu Glu Ala Lys 
                245                 250                 255     


Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His 
            260                 265                 270         


Thr Cys Ser Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His 
        275                 280                 285             


Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys 
    290                 295                 300                 


Asn Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr 
305                 310                 315                 320 


Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys His Leu 
                325                 330                 335     


Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys 
            340                 345                 350         


Arg His Met 
        355 


<210>  9900
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf2__Homo_sapiens__AAF13295

<400>  9900
auggcgcuga gugaacccau ccugccgucc uucuccacuu ucgccagccc gugccgcgag       60

cgcggccugc aggagcgcug gccgcgcgcc gaacccgagu ccggcggcac cgacgacgac      120

cucaacagcg ugcuggacuu cauccugucc auggggcugg auggccuggg cgccgaggcc      180

gccccggagc cgccgccgcc gcccccgccg ccugcguucu auuaccccga acccggcgcg      240

cccccgcccu acagcgcccc cgcggguggc cuggugucug agcugcugcg acccgagcug      300

gaugcgccgc uggggcccgc acugcacggc cgcuuucugc uggcgccgcc cggccgccug      360

gucaaggccg agcccccuga agcggacggc ggcggcggcu acggcugcgc ccccgggcug      420

acccguggac cgcgcggccu caagcgcgag ggcgccccgg gcccggcggc uucgugcaug      480

cgaggucccg ggggccgccc cccgccgccg cccgacacac cgccgcucag ccccgacggc      540

cccgcgcgcc ugcccgcgcc cgguccgcgc gccuccuucc cgccgccuuu cgguggcccu      600

gguuucggcg cgcccgggcc cggccugcau uacgcgccgc cugcgccccc agccuucggu      660

cucuucgacg acgcggccgc cgccgcggca gcccugggcc uggcgccccc cgccgcccgc      720

ggucuccuca cgccgccugc guccccgcug gagcugcugg aggccaagcc aaagcgcggc      780

cgccgcucuu ggccccgcaa acgcaccgcc acucacaccu gcagcuacgc gggcugcggc      840

aagaccuaca ccaagaguuc gcaucugaag gcgcaucugc gcacgcacac aggugagaag      900

cccuaccacu gcaacuggga cggcugcggc uggaaguuug cgcgcucaga cgagcucacg      960

cgccacuacc gaaagcacac gggccaccgg ccauuccagu gccaucugug cgaucgugcc     1020

uuuucgcgcu ccgaucaccu ggcgcugcac augaaacggc acauguag                  1068


<210>  9901
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf2__Homo_sapiens__AAF13295

<400>  9901
auggcccuga gcgagcccau ccucccgucc uucagcaccu ucgccucccc cugccgcgag       60

cggggccugc aggagcgcug gccccgggcg gagcccgaga gcgggggcac cgacgacgac      120

cugaacuccg ugcucgacuu cauccugagc auggggcugg acggccucgg ggccgaggcc      180

gccccggagc cccccccccc gccccccccc ccggccuucu acuaccccga gcccggcgcg      240

cccccgcccu acuccgcccc cgccggcggg cuggucagcg agcugcuccg ccccgagcug      300

gacgccccgc ugggccccgc gcuccacggg cgguuccugc uggccccccc cggccgccuc      360

gugaaggccg agccgcccga ggccgacggg ggcggcgggu acggcugcgc ccccgggcug      420

acgcggggcc cccgcggccu gaagcgggag ggggcgccgg gccccgccgc cuccugcaug      480

cgcgggcccg gcgggcggcc gccccccccc ccggacaccc ccccccucag ccccgacggc      540

ccggcccgcc ugcccgcccc cggcccccgg gcguccuucc cgccccccuu cgggggcccc      600

ggguucggcg ccccggggcc cggccugcac uacgcccccc ccgccccgcc cgccuucggc      660

cucuucgacg acgcggccgc cgccgccgcg gcccuggggc uggccccccc cgccgcgcgc      720

ggccuccuga ccccgcccgc cagcccccug gagcuccugg aggccaagcc gaagcggggg      780

cgccgguccu ggccccgcaa gcggaccgcc acgcacaccu gcagcuacgc cggcugcggg      840

aagaccuaca ccaaguccag ccaccugaag gcgcaccucc gcacgcacac cggcgagaag      900

cccuaccacu gcaacuggga cggcugcggg uggaaguucg cccgguccga cgagcugacc      960

cgccacuacc gcaagcacac cggccaccgg cccuuccagu gccaccugug cgaccgcgcc     1020

uucagccggu ccgaccaccu cgcccugcac augaagcgcc acauguga                  1068


<210>  9902
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf2__Homo_sapiens__AAF13295

<400>  9902
auggcccucu ccgagcccau ccuccccucc uucuccaccu ucgccucccc cugccgcgag       60

cgcggccucc aggagcgcug gccccgcgcc gagcccgagu ccggcggcac cgacgacgac      120

cucaacuccg uccucgacuu cauccucucc augggccucg acggccucgg cgccgaggcc      180

gcccccgagc cccccccccc cccccccccc cccgccuucu acuaccccga gcccggcgcc      240

cccccccccu acuccgcccc cgccggcggc cucgucuccg agcuccuccg ccccgagcuc      300

gacgcccccc ucggccccgc ccuccacggc cgcuuccucc ucgccccccc cggccgccuc      360

gucaaggccg agccccccga ggccgacggc ggcggcggcu acggcugcgc ccccggccuc      420

acccgcggcc cccgcggccu caagcgcgag ggcgcccccg gccccgccgc cuccugcaug      480

cgcggccccg gcggccgccc cccccccccc cccgacaccc ccccccucuc ccccgacggc      540

cccgcccgcc uccccgcccc cggcccccgc gccuccuucc ccccccccuu cggcggcccc      600

ggcuucggcg cccccggccc cggccuccac uacgcccccc ccgccccccc cgccuucggc      660

cucuucgacg acgccgccgc cgccgccgcc gcccucggcc ucgccccccc cgccgcccgc      720

ggccuccuca ccccccccgc cuccccccuc gagcuccucg aggccaagcc caagcgcggc      780

cgccgcuccu ggccccgcaa gcgcaccgcc acccacaccu gcuccuacgc cggcugcggc      840

aagaccuaca ccaaguccuc ccaccucaag gcccaccucc gcacccacac cggcgagaag      900

cccuaccacu gcaacuggga cggcugcggc uggaaguucg cccgcuccga cgagcucacc      960

cgccacuacc gcaagcacac cggccaccgc cccuuccagu gccaccucug cgaccgcgcc     1020

uucucccgcu ccgaccaccu cgcccuccac augaagcgcc acauguga                  1068


<210>  9903
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf2__Homo_sapiens__AAF13295

<400>  9903
auggcccuga gcgagcccau ccucccuucc uucucuaccu uugcuucacc augcagagaa       60

aggggccuuc aggagcggug gccgcgcgca gaacccgaga gugggggaac agacgaugac      120

cugaacagcg uguuggauuu cauuuuaucc augggucugg acggccuagg ggccgaagcg      180

gcuccugagc cacccccucc acccccucca ccggccuuuu acuaucccga gccuggagca      240

ccacccccuu acucugcccc agcuggcggu cucgucucgg aacugcuucg acccgagcug      300

gaugcaccgu uggggccugc ccuccacgga cguuuccugc uggcuccccc aggcagacuc      360

guuaaggccg aaccucccga ggcggacggc gggggagguu auggcugugc accaggguua      420

acuaggggac cccggggccu gaaacgcgag ggugccccug ggccagcugc cucaugcaug      480

agaggaccgg gcggcaggcc cccuccaccc ccugauacgc caccccuuag cccggacggg      540

ccugcacggu ugccagcucc cggaccucgc gccaguuuuc ccccaccuuu cgguggcccc      600

ggguuuggag cgccaggccc gggucugcau uacgccccuc ccgcaccacc cgcuuucggg      660

cuauuugaug acgccgcugc cgcagccgcu gcgcucggcc uggcaccucc agccgcucga      720

ggacuucuga cacccccugc cuccccguug gaacuccugg aggcaaagcc aaaaagaggc      780

aggcggucuu ggccccguaa gcgcaccgcc acucacaccu guagcuaugc ugggugcgga      840

aaaacauaca ccaaguccuc acauuuaaag gcccaccuga gaacucauac aggugaaaaa      900

ccuuaucacu guaauuggga uggcugcggg uggaaguucg caaggaguga cgagcucacc      960

cggcacuacc gaaaacauac gggacaccgc ccauuucaau gucaucuuug cgauagagcg     1020

uucagcaggu cugaccaccu ggcuuugcac augaagcggc auauguga                  1068


<210>  9904
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf2__Homo_sapiens__AAF13295

<400>  9904
auggcccuga gcgagcccau ccugcccagc uucagcaccu ucgccagccc cugcagagag       60

agaggccugc aggagagaug gcccagagcc gagcccgaga gcggcggcac cgacgacgac      120

cugaacagcg ugcuggacuu cauccugagc augggccugg acggccuggg cgccgaggcc      180

gcccccgagc cccccccccc cccccccccc cccgccuucu acuaccccga gcccggcgcc      240

cccccccccu acagcgcccc cgccggcggc cuggugagcg agcugcugag acccgagcug      300

gacgcccccc ugggccccgc ccugcacggc agauuccugc uggccccccc cggcagacug      360

gugaaggccg agccccccga ggccgacggc ggcggcggcu acggcugcgc ccccggccug      420

accagaggcc ccagaggccu gaagagagag ggcgcccccg gccccgccgc cagcugcaug      480

agaggccccg gcggcagacc cccccccccc cccgacaccc ccccccugag ccccgacggc      540

cccgccagac ugcccgcccc cggccccaga gccagcuucc ccccccccuu cggcggcccc      600

ggcuucggcg cccccggccc cggccugcac uacgcccccc ccgccccccc cgccuucggc      660

cuguucgacg acgccgccgc cgccgccgcc gcccugggcc uggccccccc cgccgccaga      720

ggccugcuga ccccccccgc cagcccccug gagcugcugg aggccaagcc caagagaggc      780

agaagaagcu ggcccagaaa gagaaccgcc acccacaccu gcagcuacgc cggcugcggc      840

aagaccuaca ccaagagcag ccaccugaag gcccaccuga gaacccacac cggcgagaag      900

cccuaccacu gcaacuggga cggcugcggc uggaaguucg ccagaagcga cgagcugacc      960

agacacuaca gaaagcacac cggccacaga cccuuccagu gccaccugug cgacagagcc     1020

uucagcagaa gcgaccaccu ggcccugcac augaagagac acauguga                  1068


<210>  9905
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf2__Homo_sapiens__AAF13295

<400>  9905
auggcccuga gcgagcccau ccucccuucc uucucuaccu uugcuagccc gugcagagaa       60

cggggccugc aggagcgcug gcccagagcc gaaccugagu ccgggggaac agacgaugac      120

cuuaacucug ugcuggauuu cauucucagc augggccugg acgggcuugg agcggaagcu      180

gcccccgagc cucccccucc gcccccuccc ccugccuuuu acuaucccga gccgggcgcu      240

ccucccccuu acuccgcccc cgcuggggga cuggucucug aacuccugcg gcccgagcug      300

gaugccccuc ucggcccggc gcugcacggc cgcuuccuuc uggcuccccc ugggagacuc      360

guuaaggccg aacccccuga ggccgacgga ggcgggggau auggcugugc ucccgggcug      420

acgcggggac cgcgcggccu uaaaagagag ggcgccccug ggcccgcggc cagcugcaug      480

cggggaccug gcgggagacc cccucccccg ccugauaccc cuccccuguc ccccgacgga      540

ccggcucgcc uccccgcccc uggcccccgg gcuagcuuuc cucccccuuu cgggggaccc      600

ggcuuuggcg ccccggggcc uggacugcau uacgccccuc ccgcuccccc ggcguucggc      660

cuguuugaug acgccgcugc cgccgcugcc gcgcucgggc uggcuccucc cgccgcccgc      720

ggacuucuga caccucccgc uucuccccuc gaacugcuug aggccaagcc uaaaagaggc      780

cggcgcuccu ggccgagaaa gcggaccgcu acacacaccu guagcuaugc cgggugcggc      840

aaaacauaca ccaagucuuc ccaucugaag gcgcaccuca gaacgcauac cggagaaaaa      900

cccuaucacu guaauuggga uggcugcggg uggaaguucg cccgcagcga cgagcugaca      960

cggcacuaca gaaaacauac cggacaccgc ccuuuucaau gucaucugug cgaucgggcu     1020

uucucuagau ccgaccaccu cgcccugcac augaagcgcc auauguga                  1068


<210>  9906
<211>  1068
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf2__Homo_sapiens__AAF13295

<400>  9906
auggcucuaa gugaaccaau auuaccaagu uuuucuacau uugcaucacc auguagagaa       60

agaggacuac aagaaagaug gccaagagca gaaccagaau caggaggaac agaugaugau      120

cuaaauucug uauuagacuu uauauuaucu augggauuag auggauuagg agcagaagca      180

gcaccagaac ccccaccacc accaccucca ccagcuuuuu acuacccaga accuggugcu      240

ccaccaccau auagugcacc agcaggcgga uuaguauccg aauuauuaag accagaacuu      300

gacgcuccau uaggaccagc auuacaugga agauuuuuac uagcaccacc aggaagauua      360

guaaaagcag aaccaccuga agcagauggu ggaggaggau auggaugugc accaggacua      420

acaagaggac caagaggauu aaaaagagaa ggagcaccag gaccugcagc aucaugcaug      480

agaggaccag gagguagacc accaccacca ccagauacac caccauuaag cccagaugga      540

ccugcaagau uaccugcacc uggacccaga gcuucauuuc caccuccauu uggaggacca      600

ggauuuggag caccuggucc aggacuacau uaugcuccac cagcaccccc agcauuugga      660

cuuuuugacg augccgcugc agcagcagcu gcauuaggac uagcaccacc agcagcaaga      720

gguuuacuaa cacccccagc aagcccauua gaauuacuug aagcaaaacc aaaaagaggu      780

agaagaucau ggccaagaaa aagaacugca acacauacau guaguuaugc aggcuguggu      840

aaaacauaua caaaaaguuc ucacuuaaaa gcacauuuaa gaacacauac uggagaaaaa      900

ccauaucacu guaauuggga cggaugcggu uggaaauuug cuagaucaga ugaacuaaca      960

agacauuauc gaaaacauac aggacauaga ccauuccaau gucauuuaug ugauagagcc     1020

uuuucuagau cugaucauuu agcacuucau augaaaagac auauguaa                  1068


<210>  9907
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf4__Homo_sapiens__F2VTX5

<400>  9907

Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln Ala Gly Ala Pro Asn 
            20                  25                  30          


Asn Leu Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys 
        35                  40                  45              


Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys 
    50                  55                  60                  


Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys 
65                  70                  75                  80  


Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp 
                85                  90                  95      


Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Trp His 
            100                 105                 110         


Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp 
        115                 120                 125             


Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His 
    130                 135                 140                 


Phe 
145 


<210>  9908
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf4__Homo_sapiens__ADL14248

<400>  9908
auggcuguca gcgacgcgcu gcucccaucu uucuccacgu ucgcgucugg cccggcggga       60

agggagaaga cacugcguca agcaggugcc ccgaauaacc ucaugccacc cgguuccugc      120

augccagagg agcccaagcc aaagagggga agacgaucgu ggccccggaa aaggaccgcc      180

acccacacuu gugauuacgc gggcugcggc aaaaccuaca caaagaguuc ccaucucaag      240

gcacaccugc gaacccacac aggugagaaa ccuuaccacu gugacuggga cggcugugga      300

uggaaauucg cccgcucaga ugaacugacc uggcacuacc guaaacacac ggggcaccgc      360

ccguuccagu gccaaaaaug cgaccgagca uuuuccaggu cggaccaccu cgccuuacac      420

augaagaggc auuuuuaa                                                    438


<210>  9909
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf4__Homo_sapiens__ADL14248

<400>  9909
auggccguga gcgacgcccu gcuccccucc uucagcaccu ucgcguccgg cccggccggg       60

cgcgagaaga cccugcggca ggccggcgcc cccaacaacc ugaugccgcc cgggagcugc      120

augcccgagg agcccaagcc caagcgcggc cggcgcuccu ggccccggaa gcgcacggcc      180

acccacacgu gcgacuacgc ggggugcggc aagaccuaca ccaagagcuc ccaccucaag      240

gcccaccucc ggacccacac cggcgagaag ccguaccacu gcgacuggga cgggugcggc      300

uggaaguucg cccgcagcga cgagcugacc uggcacuacc ggaagcacac ggggcaccgc      360

cccuuccagu gccagaagug cgaccgggcc uucucccgca gcgaccaccu ggcgcugcac      420

augaagcggc acuucuga                                                    438


<210>  9910
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf4__Homo_sapiens__ADL14248

<400>  9910
auggccgucu ccgacgcccu ccuccccucc uucuccaccu ucgccuccgg ccccgccggc       60

cgcgagaaga cccuccgcca ggccggcgcc cccaacaacc ucaugccccc cggcuccugc      120

augcccgagg agcccaagcc caagcgcggc cgccgcuccu ggccccgcaa gcgcaccgcc      180

acccacaccu gcgacuacgc cggcugcggc aagaccuaca ccaaguccuc ccaccucaag      240

gcccaccucc gcacccacac cggcgagaag cccuaccacu gcgacuggga cggcugcggc      300

uggaaguucg cccgcuccga cgagcucacc uggcacuacc gcaagcacac cggccaccgc      360

cccuuccagu gccagaagug cgaccgcgcc uucucccgcu ccgaccaccu cgcccuccac      420

augaagcgcc acuucuga                                                    438


<210>  9911
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf4__Homo_sapiens__ADL14248

<400>  9911
auggccguga gcgacgcucu gcuccccucc uucucuaccu uugcaucagg cccugccggg       60

agagagaaga cacuuaggca ggcgggagcu ccaaacaauc ugaugccgcc cgguaguugc      120

augccugagg aaccaaaacc caagcggggc cgccgaagcu ggccucguaa aagaacugcc      180

acgcacaccu gugauuacgc agggugcgga aagacauaua cuaaauccuc ucauuugaag      240

gcccacuuaa ggacccauac aggcgaaaag ccauaccacu gugacuggga ugguugcggg      300

uggaaauucg cucggucgga cgagcugacc uggcauuauc gcaagcacac uggacacaga      360

cccuuucaau gucagaaaug cgauagggca uucucacgga gcgaccaucu agcccuccac      420

augaagcgcc auuuuuga                                                    438


<210>  9912
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf4__Homo_sapiens__ADL14248

<400>  9912
auggccguga gcgacgcccu gcugcccagc uucagcaccu ucgccagcgg ccccgccggc       60

agagagaaga cccugagaca ggccggcgcc cccaacaacc ugaugccccc cggcagcugc      120

augcccgagg agcccaagcc caagagaggc agaagaagcu ggcccagaaa gagaaccgcc      180

acccacaccu gcgacuacgc cggcugcggc aagaccuaca ccaagagcag ccaccugaag      240

gcccaccuga gaacccacac cggcgagaag cccuaccacu gcgacuggga cggcugcggc      300

uggaaguucg ccagaagcga cgagcugacc uggcacuaca gaaagcacac cggccacaga      360

cccuuccagu gccagaagug cgacagagcc uucagcagaa gcgaccaccu ggcccugcac      420

augaagagac acuucuga                                                    438


<210>  9913
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf4__Homo_sapiens__ADL14248

<400>  9913
auggccguga gcgacgcucu gcuccccucc uucucuaccu uugccagcgg cccugcgggg       60

agagagaaga cacugcggca ggcuggagcc ccgaacaauc uuaugccccc uggcuccugc      120

augcccgagg aaccuaaacc caagcgcggg agacggucuu ggccucgcaa aagaacggcc      180

acccacacau gugauuacgc uggaugcggc aagaccuaua caaaaagcuc ccaucugaag      240

gcccaccucc ggacccauac aggggaaaag ccguaccacu gugacuggga uggaugcggc      300

uggaaauucg cucgcucuga cgagcugacc uggcauuaua gaaagcacac gggccaccgg      360

cccuuucaau gucagaaaug cgaucgcgcc uucagcagau ccgaccaucu ugcgcugcac      420

augaagcggc auuuuuga                                                    438


<210>  9914
<211>  438
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf4__Homo_sapiens__ADL14248

<400>  9914
auggcaguaa gcgaugcauu acuaccauca uuuagcacau ucgcaagcgg accagcagga       60

agagaaaaaa cauuaagaca agcaggagca ccaaacaacu uaaugccacc aggaucaugc      120

augccagaag aaccaaaacc aaaaagagga agaagaucau ggccaagaaa aagaacagca      180

acacacacau gugauuacgc aggaugcgga aaaacauaca caaaaagcuc acacuuaaaa      240

gcacacuuaa gaacacacac aggagaaaaa ccauaccauu gcgauuggga uggaugugga      300

uggaaauuug caagaagcga ugaauuaaca uggcacuaua gaaaacacac aggacacaga      360

ccauuccaau gccaaaaaug ugacagagca uuuagcagaa gcgaucacuu agcauuacac      420

augaaaagac acuuuuaa                                                    438


<210>  9915
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf4__Homo_sapiens__L0R3V2

<400>  9915

Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
1               5                   10                  15      


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
            20                  25                  30          


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
        35                  40                  45              


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
    50                  55                  60                  


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
65                  70                  75                  80  


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
                85                  90                  95      


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
            100                 105                 110     


<210>  9916
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf4__Homo_sapiens__CCO02799

<400>  9916
augccacccg guuccugcau gccagaggag cccaagccaa agaggggaag acgaucgugg       60

ccccggaaaa ggaccgccac ccacacuugu gauuacgcgg gcugcggcaa aaccuacaca      120

aagaguuccc aucucaaggc acaccugcga acccacacag gugagaaacc uuaccacugu      180

gacugggacg gcuguggaug gaaauucgcc cgcucagaug aacugaccag gcacuaccgu      240

aaacacacgg ggcaccgccc guuccagugc caaaaaugcg accgagcauu uuccaggucg      300

gaccaccucg ccuuacacau gaagaggcau uuuuaa                                336


<210>  9917
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf4__Homo_sapiens__CCO02799

<400>  9917
augcccccgg gcagcugcau gcccgaggag cccaagccca agcgcgggcg gcgcuccugg       60

ccgcggaagc gcaccgccac ccacacgugc gacuacgccg gcugcgggaa gaccuacacc      120

aagagcuccc accugaaggc gcaccuccgg acccacacgg gcgagaagcc cuaccacugc      180

gacugggacg ggugcggcug gaaguucgcc cgcagcgacg agcugacccg gcacuaccgc      240

aagcacaccg gccaccggcc cuuccagugc cagaagugcg accgcgccuu cucccggagc      300

gaccaccugg cccuccacau gaagcgccac uucuga                                336


<210>  9918
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf4__Homo_sapiens__CCO02799

<400>  9918
augccccccg gcuccugcau gcccgaggag cccaagccca agcgcggccg ccgcuccugg       60

ccccgcaagc gcaccgccac ccacaccugc gacuacgccg gcugcggcaa gaccuacacc      120

aaguccuccc accucaaggc ccaccuccgc acccacaccg gcgagaagcc cuaccacugc      180

gacugggacg gcugcggcug gaaguucgcc cgcuccgacg agcucacccg ccacuaccgc      240

aagcacaccg gccaccgccc cuuccagugc cagaagugcg accgcgccuu cucccgcucc      300

gaccaccucg cccuccacau gaagcgccac uucuga                                336


<210>  9919
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf4__Homo_sapiens__CCO02799

<400>  9919
augcccccug gcagcugcau gccagaggaa ccgaagccca aaagagggag gcgguccugg       60

ccucgcaagc gaaccgccac acacacuugu gacuacgcug gaugcgguaa aacguauacc      120

aagucuucac aucugaaagc acaccuccgu acacauacug gcgagaagcc auaccacugu      180

gauugggacg ggugcggaug gaaguucgcc agaagugaug aacuuaccag gcauuaucgg      240

aaacacacag gccaccgccc cuuucagugu caaaagugcg acagagcguu cagcaggucc      300

gaucaucugg cuuugcacau gaaacggcau uuuuga                                336


<210>  9920
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf4__Homo_sapiens__CCO02799

<400>  9920
augccccccg gcagcugcau gcccgaggag cccaagccca agagaggcag aagaagcugg       60

cccagaaaga gaaccgccac ccacaccugc gacuacgccg gcugcggcaa gaccuacacc      120

aagagcagcc accugaaggc ccaccugaga acccacaccg gcgagaagcc cuaccacugc      180

gacugggacg gcugcggcug gaaguucgcc agaagcgacg agcugaccag acacuacaga      240

aagcacaccg gccacagacc cuuccagugc cagaagugcg acagagccuu cagcagaagc      300

gaccaccugg cccugcacau gaagagacac uucuga                                336


<210>  9921
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf4__Homo_sapiens__CCO02799

<400>  9921
augcccccug gcagcugcau gccggaggaa cccaagccua aaagagggcg gcgcuccugg       60

cccagaaagc ggaccgccac acacacgugu gacuacgcug gaugcggcaa aaccuauaca      120

aagucuagcc aucugaaagc ccaccuccgc acccauacag gggagaagcc uuaccacugu      180

gauugggacg gaugcggcug gaaguucgcg agauccgaug aacugacccg gcauuaucgc      240

aaacacacag ggcacagacc cuuucagugu caaaagugcg accgggcuuu cucucgcagc      300

gaucaucuug cccugcacau gaaaagacau uuuuga                                336


<210>  9922
<211>  336
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf4__Homo_sapiens__CCO02799

<400>  9922
augccaccag gaucaugcau gccagaagaa ccaaaaccaa aaagaggaag aagaucaugg       60

ccaagaaaaa gaacagcaac acacacaugc gacuacgcag gaugcggaaa aacauacaca      120

aaaucaucac accuaaaagc acaccuaaga acacacacag gagaaaaacc auaccacugc      180

gacugggacg gaugcggaug gaaauucgca agaucagacg aacuaacaag acacuacaga      240

aaacacacag gacacagacc auuccaaugc caaaaaugcg acagagcauu cucaagauca      300

gaccaccuag cacuacacau gaaaagacac uucuaa                                336


<210>  9923
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__A0A0A0N0L4

<400>  9923

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Val Pro 
1               5                   10                  15      


Gln Pro Pro Ala Pro Gln Asp Glu Pro Val Phe Ala Gln Leu Lys Pro 
            20                  25                  30          


Val Leu Gly Ala Ala Asn Pro Ala Arg Asp Ala Ala Leu Phe Pro Gly 
        35                  40                  45              


Glu Glu Leu Lys His Ala His His Arg Pro Gln Ala Gln Pro Ala Ala 
    50                  55                  60                  


Ala Ser Arg Gly Pro Gly Pro Asp Lys Met 
65                  70                  


<210>  9924
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__AER93390

<400>  9924
auggcuacaa gggugcugag caugagcgcc cgccugggac ccgugcccca gccgccggcg       60

ccgcaggacg agccgguguu cgcgcagcuc aagccggugc ugggcgccgc gaauccggcc      120

cgcgacgcgg cgcucuuccc cggcgaggag cugaagcacg cgcaccaccg cccgcaggcg      180

cagcccgcgg cugccuccag aggaccuggu ccagacaaga uguga                      225


<210>  9925
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf5__Homo_sapiens__AER93390

<400>  9925
auggccaccc gcgugcugag cauguccgcc cggcucggcc ccgucccgca gccgcccgcg       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggggccgc caaccccgcc      120

cgcgacgcgg cccucuuccc cggcgaggag cugaagcacg cccaccaccg gccgcaggcc      180

cagcccgcgg ccgccagccg cgggcccggc cccgacaaga uguga                      225


<210>  9926
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf5__Homo_sapiens__AER93390

<400>  9926
auggccaccc gcguccucuc cauguccgcc cgccucggcc ccguccccca gccccccgcc       60

ccccaggacg agcccgucuu cgcccagcuc aagcccgucc ucggcgccgc caaccccgcc      120

cgcgacgccg cccucuuccc cggcgaggag cucaagcacg cccaccaccg cccccaggcc      180

cagcccgccg ccgccucccg cggccccggc cccgacaaga uguga                      225


<210>  9927
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf5__Homo_sapiens__AER93390

<400>  9927
auggccacca gagugcugag cauguccgcu aggcucggcc ccgucccuca gccaccggca       60

ccccaagacg agccuguuuu cgcccagcuu aagccagugc ugggggcggc uaaccccgcc      120

cgggaugcag ccuuguuucc uggagaagag uuaaaacacg cucaucaccg cccacaggca      180

cagcccgccg cugccucucg agguccuggc ccagacaaga uguga                      225


<210>  9928
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf5__Homo_sapiens__AER93390

<400>  9928
auggccacca gagugcugag caugagcgcc agacugggcc ccgugcccca gccccccgcc       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggcgccgc caaccccgcc      120

agagacgccg cccuguuccc cggcgaggag cugaagcacg cccaccacag accccaggcc      180

cagcccgccg ccgccagcag aggccccggc cccgacaaga uguga                      225


<210>  9929
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf5__Homo_sapiens__AER93390

<400>  9929
auggccacca gagugcugag cauguccgcu cggcucggcc ccgucccuca gccgcccgcc       60

ccucaagacg agcccguuuu cgcgcagcug aagccugugc uuggggcugc caaccccgcc      120

cgcgaugcug cccuguuucc uggagaggaa cucaaacacg cucaucacag accgcaggcc      180

cagcccgcgg ccgcuucucg gggcccuggg cccgacaaga uguga                      225


<210>  9930
<211>  225
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf5__Homo_sapiens__AER93390

<400>  9930
auggcaacaa gaguauuaag caugagcgca agauuaggac caguaccaca accaccagca       60

ccacaagacg aaccaguauu cgcacaauua aaaccaguau uaggagcagc aaauccagca      120

agagaugcag cacuauuucc aggagaagaa uuaaaacacg cacaccauag accacaagca      180

caaccagcag cagcaucaag aggaccagga ccagauaaaa uguaa                      225


<210>  9931
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__A0A0A0N0L7

<400>  9931

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Gly Pro Asp Lys Met 
            20                  25      


<210>  9932
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__AER93389

<400>  9932
auggcuacaa gggugcugag caugagcgcc cgccugggac ccgcggcugc cuccagagga       60

ccugguccag acaagaugug a                                                 81


<210>  9933
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf5__Homo_sapiens__AER93389

<400>  9933
auggccaccc gcgugcugag cauguccgcc cggcucggcc ccgcggccgc cagccgcggg       60

ccgggccccg acaagaugug a                                                 81


<210>  9934
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf5__Homo_sapiens__AER93389

<400>  9934
auggccaccc gcguccucuc cauguccgcc cgccucggcc ccgccgccgc cucccgcggc       60

cccggccccg acaagaugug a                                                 81


<210>  9935
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf5__Homo_sapiens__AER93389

<400>  9935
auggccacca gagugcugag cauguccgcu aggcucggcc ccgcagccgc gucucggggg       60

ccuggaccag acaagaugug a                                                 81


<210>  9936
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf5__Homo_sapiens__AER93389

<400>  9936
auggccacca gagugcugag caugagcgcc agacugggcc ccgccgccgc cagcagaggc       60

cccggccccg acaagaugug a                                                 81


<210>  9937
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf5__Homo_sapiens__AER93389

<400>  9937
auggccacca gagugcugag cauguccgcu cggcucggcc ccgccgcggc uucucgcggg       60

ccuggaccgg acaagaugug a                                                 81


<210>  9938
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf5__Homo_sapiens__AER93389

<400>  9938
auggcaacaa gaguauuaag caugagcgca agauuaggac cagcagcagc aucaagagga       60

ccaggaccag auaaaaugua a                                                 81


<210>  9939
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__A0A0A0N0M4

<400>  9939

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Val Pro 
1               5                   10                  15      


Gln Pro Pro Ala Pro Gln Asp Glu Pro Val Phe Ala Gln Leu Lys Pro 
            20                  25                  30          


Val Leu Gly Ala Ala Asn Pro Ala Arg Asp Ala Ala Leu Phe Pro Gly 
        35                  40                  45              


Glu Glu Leu Lys His Ala His His Arg Pro Gln Ala Pro Gln Pro Ala 
    50                  55                  60                  


Gln Pro Pro Ala Thr Gly Pro Arg Leu Pro Pro Glu Asp Leu Val Gln 
65                  70                  75                  80  


Thr Arg Cys Glu Met Glu Lys Tyr Leu Thr Pro Gln Leu Pro Pro Val 
                85                  90                  95      


Pro Ile Ile Pro Glu His Lys Lys Tyr Arg Arg Asp Ser Ala Ser Val 
            100                 105                 110         


Val Asp Gln Phe Phe Thr Asp Thr Glu Gly Leu Pro Tyr Ser Ile Asn 
        115                 120                 125             


Met Asn Val Phe Leu Pro Asp Ile Thr His Leu Arg Thr Gly Leu Tyr 
    130                 135                 140                 


Lys Ser Gln Arg Pro Cys Val Thr His Ile Lys Thr Glu Pro Val Ala 
145                 150                 155                 160 


Ile Phe Ser His Gln Ser Glu Thr Thr Ala Pro Pro Pro Ala Pro Thr 
                165                 170                 175     


Gln Ala Leu Pro Glu Phe Thr Ser Ile Phe Ser Ser His Gln Thr Ala 
            180                 185                 190         


Ala Pro Glu Val Asn Asn Ile Phe Ile Lys Gln Glu Leu Pro Thr Pro 
        195                 200                 205             


Asp Leu His Leu Ser Val Pro Thr Gln Gln Gly His Leu Tyr Gln Leu 
    210                 215                 220                 


Leu Asn Thr Pro Asp Leu Asp Met Pro Ser Ser Thr Asn Gln Thr Ala 
225                 230                 235                 240 


Ala Met Asp Thr Leu Asn Val Ser Met Ser Ala Ala Met Ala Gly Leu 
                245                 250                 255     


Asn Thr His Thr Ser Ala Val Pro Gln Thr Ala Val Lys Gln Phe Gln 
            260                 265                 270         


Gly Met Pro Pro Cys Thr Tyr Thr Met Pro Ser Gln Phe Leu Pro Gln 
        275                 280                 285             


Gln Ala Thr Tyr Phe Pro Pro Ser Pro Pro Ser Ser Glu Pro Gly Ser 
    290                 295                 300                 


Pro Asp Arg Gln Ala Glu Met Leu Gln Asn Leu Thr Pro Pro Pro Ser 
305                 310                 315                 320 


Tyr Ala Ala Thr Ile Ala Ser Lys Leu Ala Ile His Asn Pro Asn Leu 
                325                 330                 335     


Pro Thr Thr Leu Pro Val Asn Ser Gln Asn Ile Gln Pro Val Arg Tyr 
            340                 345                 350         


Asn Arg Arg Ser Asn Pro Asp Leu Glu Lys Arg Arg Ile His Tyr Cys 
        355                 360                 365             


Asp Tyr Pro Gly Cys Thr Lys Val Tyr Thr Lys Ser Ser His Leu Lys 
    370                 375                 380                 


Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp 
385                 390                 395                 400 


Glu Gly Cys Asp Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His 
                405                 410                 415     


Tyr Arg Lys His Thr Gly Ala Lys Pro Phe Gln Cys Gly Val Cys Asn 
            420                 425                 430         


Arg Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His 
        435                 440                 445             


Gln Asn 
    450 


<210>  9940
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__AER93391

<400>  9940
auggcuacaa gggugcugag caugagcgcc cgccugggac ccgugcccca gccgccggcg       60

ccgcaggacg agccgguguu cgcgcagcuc aagccggugc ugggcgccgc gaauccggcc      120

cgcgacgcgg cgcucuuccc cggcgaggag cugaagcacg cgcaccaccg cccgcaggcc      180

ccgcagccgg cccagccgcc cgccaccggc ccgcggcugc cuccagagga ccugguccag      240

acaagaugug aaauggagaa guaucugaca ccucagcuuc cuccaguucc uauaauucca      300

gagcauaaaa aguauagacg agacagugcc ucagucguag accaguucuu cacugacacu      360

gaaggguuac cuuacaguau caacaugaac gucuuccucc cugacaucac ucaccugaga      420

acuggccucu acaaauccca gagaccgugc guaacacaca ucaagacaga accuguugcc      480

auuuucagcc accagaguga aacgacugcc ccuccuccgg ccccgaccca ggcccucccu      540

gaguucacca guauauucag cucacaccag accgcagcuc cagaggugaa caauauuuuc      600

aucaaacaag aacuuccuac accagaucuu caucuuucug ucccuaccca gcagggccac      660

cuguaccagc uacugaauac accggaucua gauaugccca guucuacaaa ucagacagca      720

gcaauggaca cucuuaaugu uucuauguca gcugccaugg caggccuuaa cacacacacc      780

ucugcuguuc cgcagacugc agugaaacaa uuccagggca ugcccccuug cacauacaca      840

augccaaguc aguuucuucc acaacaggcc acuuacuuuc ccccgucacc accaagcuca      900

gagccuggaa guccagauag acaagcagag augcuccaga auuuaacccc accuccaucc      960

uaugcugcua caauugcuuc uaaacuggca auucacaauc caaauuuacc caccacccug     1020

ccaguuaacu cacaaaacau ccaaccuguc agauacaaua gaaggaguaa ccccgauuug     1080

gagaaacgac gcauccacua cugcgauuac ccugguugca caaaaguuua uaccaagucu     1140

ucucauuuaa aagcucaccu gaggacucac acuggugaaa agccauacaa guguaccugg     1200

gaaggcugcg acuggagguu cgcgcgaucg gaugagcuga cccgccacua ccggaagcac     1260

acaggcgcca agcccuucca gugcggggug ugcaaccgca gcuucucgcg cucugaccac     1320

cuggcccugc auaugaagag gcaccagaac uga                                  1353


<210>  9941
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf5__Homo_sapiens__AER93391

<400>  9941
auggccaccc gcgugcugag cauguccgcc cggcucggcc ccgucccgca gccgcccgcg       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggggccgc caaccccgcc      120

cgcgacgcgg cccucuuccc cggcgaggag cugaagcacg cccaccaccg gccgcaggcg      180

ccccagcccg cccagccccc ggccaccggg ccccgccugc cgcccgagga ccucguccag      240

acgcggugcg agauggagaa guaccugacg ccccagcugc cgcccgugcc caucaucccc      300

gagcacaaga aguaccgccg ggacagcgcc uccguggucg accaguucuu caccgacacc      360

gagggccucc ccuacagcau caacaugaac guguuccugc ccgacaucac ccaccuccgc      420

accgggcugu acaaguccca gcggcccugc gugacccaca ucaagaccga gccggucgcc      480

aucuucagcc accaguccga gacgaccgcc ccgccgcccg cgcccaccca ggcccugccc      540

gaguucacca gcaucuucuc cagccaccag acggccgccc ccgaggugaa caacaucuuc      600

aucaagcagg agcugcccac ccccgaccuc caccuguccg ugcccaccca gcagggccac      660

cuguaccagc uccugaacac ccccgaccug gacaugccga gcuccacgaa ccagaccgcc      720

gcgauggaca cccucaacgu cagcaugucc gccgccaugg ccggccugaa cacccacacg      780

agcgccgugc cccagaccgc ggugaagcag uuccagggga ugccgcccug caccuacacc      840

augcccuccc aguuccugcc ccagcaggcc acguacuucc cgcccagccc gcccuccagc      900

gagcccggca gccccgaccg ccaggccgag augcuccaga accugacgcc cccgcccucc      960

uacgccgcca ccaucgcgag caagcuggcc auccacaacc ccaaccuccc caccacccug     1020

cccgucaacu cccagaacau ccagcccgug cgguacaacc gccggagcaa ccccgaccug     1080

gagaagcgcc ggauccacua cugcgacuac ccggggugca ccaaggugua caccaagucc     1140

agccaccuca aggcccaccu ccgcacccac acgggcgaga agcccuacaa gugcaccugg     1200

gaggggugcg acuggcgguu cgcccgcucc gacgagcuga cccggcacua ccgcaagcac     1260

accggcgcga agcccuucca gugcggcguc ugcaaccgga gcuucucccg cagcgaccac     1320

cuggcccugc acaugaagcg ccaccagaac uga                                  1353


<210>  9942
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf5__Homo_sapiens__AER93391

<400>  9942
auggccaccc gcguccucuc cauguccgcc cgccucggcc ccguccccca gccccccgcc       60

ccccaggacg agcccgucuu cgcccagcuc aagcccgucc ucggcgccgc caaccccgcc      120

cgcgacgccg cccucuuccc cggcgaggag cucaagcacg cccaccaccg cccccaggcc      180

ccccagcccg cccagccccc cgccaccggc ccccgccucc cccccgagga ccucguccag      240

acccgcugcg agauggagaa guaccucacc ccccagcucc cccccguccc caucaucccc      300

gagcacaaga aguaccgccg cgacuccgcc uccgucgucg accaguucuu caccgacacc      360

gagggccucc ccuacuccau caacaugaac gucuuccucc ccgacaucac ccaccuccgc      420

accggccucu acaaguccca gcgccccugc gucacccaca ucaagaccga gcccgucgcc      480

aucuucuccc accaguccga gaccaccgcc cccccccccg cccccaccca ggcccucccc      540

gaguucaccu ccaucuucuc cucccaccag accgccgccc ccgaggucaa caacaucuuc      600

aucaagcagg agcuccccac ccccgaccuc caccucuccg uccccaccca gcagggccac      660

cucuaccagc uccucaacac ccccgaccuc gacaugcccu ccuccaccaa ccagaccgcc      720

gccauggaca cccucaacgu cuccaugucc gccgccaugg ccggccucaa cacccacacc      780

uccgccgucc cccagaccgc cgucaagcag uuccagggca ugccccccug caccuacacc      840

augcccuccc aguuccuccc ccagcaggcc accuacuucc cccccucccc ccccuccucc      900

gagcccggcu cccccgaccg ccaggccgag augcuccaga accucacccc cccccccucc      960

uacgccgcca ccaucgccuc caagcucgcc auccacaacc ccaaccuccc caccacccuc     1020

cccgucaacu cccagaacau ccagcccguc cgcuacaacc gccgcuccaa ccccgaccuc     1080

gagaagcgcc gcauccacua cugcgacuac cccggcugca ccaaggucua caccaagucc     1140

ucccaccuca aggcccaccu ccgcacccac accggcgaga agcccuacaa gugcaccugg     1200

gagggcugcg acuggcgcuu cgcccgcucc gacgagcuca cccgccacua ccgcaagcac     1260

accggcgcca agcccuucca gugcggcguc ugcaaccgcu ccuucucccg cuccgaccac     1320

cucgcccucc acaugaagcg ccaccagaac uga                                  1353


<210>  9943
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf5__Homo_sapiens__AER93391

<400>  9943
auggccacca gagugcugag cauguccgcu aggcucggcc ccgucccuca gccaccggca       60

ccccaagacg agccuguuuu cgcccagcuu aagccagugc ugggggcggc uaaccccgcc      120

cgggaugcag ccuuguuucc uggagaagag uuaaaacacg cucaucaccg cccacaggca      180

ccccagccug cccaaccacc ggcuacaggu ccccgacugc cuccagaaga ccuaguacag      240

acucguugcg agauggaaaa guaccucacg ccccagcugc cuccagugcc caucauuccg      300

gagcauaaaa aguauagaag ggauucugcc ucagucgugg accaguucuu uaccgauaca      360

gagggccuuc cuuacaguau aaauaugaac guuuuccugc ccgacaucac ucacuugcgg      420

accgggcucu auaaaagcca acgcccaugu gugacacaua uuaagaccga accugucgcg      480

aucuuuuccc accagucuga gacuacagca cccccacccg ccccuaccca ggcucugcca      540

gaguucacgu cgauuuuuag cagccaccag acugccgcac cggaagugaa uaacaucuuc      600

auaaagcaag agcugcccac cccugaucuc cauuuaagug uaccaacaca gcagggacac      660

cuguaccaac uuuugaauac ucccgaccug gauaugccuu ccucuaccaa ccagacagcu      720

gccauggaca cccuaaaugu uagcaugucc gcggccaugg caggccucaa cacgcauacu      780

ucagcugugc cacagacagc cgucaaacag uuucaaggua ugcccccgug caccuauacu      840

augccuaguc aguuccugcc acagcaggcu acauacuuuc ccccuucacc cccaucuucc      900

gaaccugggu cacccgauag acaagccgag augcuucaga aucugacccc accgccuagc      960

uaugcagcca cgaucgcuag uaaguuggcg auucacaacc ccaaucuccc aaccacacug     1020

cccgugaacu cucagaauau ccagccugug agguacaacc ggcgcuccaa uccagacuua     1080

gaaaaacgaa ggauucacua cugugauuau cccggaugca cuaaggucua caccaaaagc     1140

ucgcaucuga aggcacaccu cagaacacau acuggcgaga agccuuauaa auguaccugg     1200

gaaggcugcg acuggcgguu cgcccguucu gacgagcuua cacgccacua cagaaagcau     1260

accggggcua aaccguuuca auguggaguu ugcaacaggu ccuucucacg gagugaucac     1320

cuggccuugc acaugaagcg acaucagaac uga                                  1353


<210>  9944
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf5__Homo_sapiens__AER93391

<400>  9944
auggccacca gagugcugag caugagcgcc agacugggcc ccgugcccca gccccccgcc       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggcgccgc caaccccgcc      120

agagacgccg cccuguuccc cggcgaggag cugaagcacg cccaccacag accccaggcc      180

ccccagcccg cccagccccc cgccaccggc cccagacugc cccccgagga ccuggugcag      240

accagaugcg agauggagaa guaccugacc ccccagcugc cccccgugcc caucaucccc      300

gagcacaaga aguacagaag agacagcgcc agcguggugg accaguucuu caccgacacc      360

gagggccugc ccuacagcau caacaugaac guguuccugc ccgacaucac ccaccugaga      420

accggccugu acaagagcca gagacccugc gugacccaca ucaagaccga gcccguggcc      480

aucuucagcc accagagcga gaccaccgcc cccccccccg cccccaccca ggcccugccc      540

gaguucacca gcaucuucag cagccaccag accgccgccc ccgaggugaa caacaucuuc      600

aucaagcagg agcugcccac ccccgaccug caccugagcg ugcccaccca gcagggccac      660

cuguaccagc ugcugaacac ccccgaccug gacaugccca gcagcaccaa ccagaccgcc      720

gccauggaca cccugaacgu gagcaugagc gccgccaugg ccggccugaa cacccacacc      780

agcgccgugc cccagaccgc cgugaagcag uuccagggca ugccccccug caccuacacc      840

augcccagcc aguuccugcc ccagcaggcc accuacuucc cccccagccc ccccagcagc      900

gagcccggca gccccgacag acaggccgag augcugcaga accugacccc cccccccagc      960

uacgccgcca ccaucgccag caagcuggcc auccacaacc ccaaccugcc caccacccug     1020

cccgugaaca gccagaacau ccagcccgug agauacaaca gaagaagcaa ccccgaccug     1080

gagaagagaa gaauccacua cugcgacuac cccggcugca ccaaggugua caccaagagc     1140

agccaccuga aggcccaccu gagaacccac accggcgaga agcccuacaa gugcaccugg     1200

gagggcugcg acuggagauu cgccagaagc gacgagcuga ccagacacua cagaaagcac     1260

accggcgcca agcccuucca gugcggcgug ugcaacagaa gcuucagcag aagcgaccac     1320

cuggcccugc acaugaagag acaccagaac uga                                  1353


<210>  9945
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf5__Homo_sapiens__AER93391

<400>  9945
auggccacca gagugcugag cauguccgcu cggcucggcc ccgucccuca gccgcccgcc       60

ccucaagacg agcccguuuu cgcgcagcug aagccugugc uuggggcugc caaccccgcc      120

cgcgaugcug cccuguuucc uggagaagaa cucaaacacg cucaucacag accgcaggcg      180

ccccagccug cccaaccccc ugccacaggc ccccggcugc cgccugaaga ccuugugcag      240

acgcgcugcg agauggaaaa guaccugaca ccccagcucc cucccguccc caucauuccu      300

gagcauaaaa aguauagacg ggauucugcu agcgugguug accaguucuu uaccgauacc      360

gaggggcugc cguacuccau caauaugaac guguuccugc ccgacauuac acaccuccgc      420

accggacugu auaaaucuca aagaccuugu gucacacaua ucaagaccga acccguggcc      480

auuuuuagcc accaguccga gacgaccgcu ccucccccgg ccccuacaca ggcgcuuccc      540

gaguucaccu cuaucuuuag cucccaccag acagccgcuc cugagguuaa uaacaucuuc      600

auuaagcaag agcugcccac cccugaucuc caucugagcg ugcccacgca gcagggccac      660

cuuuaccaac ugcucaauac accggaccug gauaugccuu cuuccaccaa ccagacagcc      720

gcuauggaca cccugaaugu cagcaugucu gccgccaugg cugggcucaa cacccauaca      780

uccgcggugc cccagacggc cgugaaacag uuucaaggaa ugcccccuug caccuauaca      840

augccgagcc aguuccugcc ccagcaggcu accuacuuuc cucccucucc ucccuccagc      900

gaaccuggcu cccccgaucg gcaagccgag augcuucaga aucugacacc gccucccucu      960

uaugccgcua ccaucgccag caagcucgcg auucacaacc cuaaucugcc cacgacacuu     1020

ccggucaacu cccagaauau ccagccuguu cgcuacaaca gacggagcaa ucccgaccug     1080

gaaaaacgcc ggauucacua cugugauuau ccuggcugca ccaaggugua caccaaaucu     1140

ucccaucuca aggcucaccu gagaacacau accggggaga agcccuauaa auguacaugg     1200

gaaggaugcg acuggcgcuu cgccagaagc gacgagcuga cgcggcacua cagaaagcau     1260

accggcgcca aacccuuuca auguggggug ugcaaccgcu cuuucagccg guccgaucac     1320

cucgcucugc acaugaagag acaucagaac uga                                  1353


<210>  9946
<211>  1353
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf5__Homo_sapiens__AER93391

<400>  9946
auggcaacua gaguacuauc uaugucagca cgacuagguc caguaccuca accaccugca       60

ccccaagaug aacccguauu ugcccaauua aaaccaguau uaggagcagc aaacccugca      120

agagacgcag cacuauuccc aggagaagaa cuaaaacacg cacaccaucg accacaagca      180

ccacaaccug cacaaccccc cgcaacagga ccaagacuuc caccagaaga uuuaguacaa      240

acaagaugug aaauggaaaa guaucuaaca ccacaacuac caccaguacc aauaauacca      300

gaacacaaaa aauacagaag agacucagca ucaguagucg aucaauucuu uacagacaca      360

gaaggauuac cauacucaau aaacaugaac guauuuuuac cagacauaac acaccuuaga      420

acaggacucu acaaaucaca acgaccaugu guaacccaca uaaaaacaga accaguugca      480

auauucuccc accaaucaga aacaaccgca cccccaccag ccccaaccca agcccuacca      540

gaauucacau caauauucuc uucacaucaa acugcagcac cagaaguaaa caacauauuc      600

auaaaacaag aacuacccac accugauuua caucuaagug uacccacaca acaaggacac      660

cuauaucaau uacucaacac accagaccuc gauaugccau caucaacuaa ucaaacugca      720

gcaauggaca cacucaacgu uucaauguca gcagccaugg cuggucuuaa cacccauaca      780

ucagcgguac cccaaacagc aguaaaacaa uuucaaggaa ugccaccaug cacauacaca      840

augccaucuc aauuucuacc ccaacaagcu acauacuucc ccccaucacc accauccuca      900

gaaccaggau caccagaccg acaagccgaa auguuacaga aucuaacucc accaccauca      960

uacgcagcaa caaucgccuc aaaacuugca auacauaacc ccaaccuacc uacuacauua     1020

cccgucaacu cacaaaacau ccaaccaguc cgauacaaca gaagaucaaa uccugaccua     1080

gaaaaaagac gcauacacua uugcgacuac cccggcugca ccaaaguaua cacaaaaucu     1140

ucccaccuua aagcacacuu aagaacacac accggagaaa aaccauauaa augcacaugg     1200

gaaggaugcg acuggagauu ugcacgaucc gacgaacuaa cucgucauua cagaaaacau     1260

acuggcgcca aacccuuuca augcggagua ugcaaccgau ccuucucaag aucagaucau     1320

cuagcauuac acaugaaaag acaccaaaac uaa                                  1353


<210>  9947
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__Q13887

<400>  9947

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Val Pro 
1               5                   10                  15      


Gln Pro Pro Ala Pro Gln Asp Glu Pro Val Phe Ala Gln Leu Lys Pro 
            20                  25                  30          


Val Leu Gly Ala Ala Asn Pro Ala Arg Asp Ala Ala Leu Phe Pro Gly 
        35                  40                  45              


Glu Glu Leu Lys His Ala His His Arg Pro Gln Ala Gln Pro Ala Pro 
    50                  55                  60                  


Ala Gln Ala Pro Gln Pro Ala Gln Pro Pro Ala Thr Gly Pro Arg Leu 
65                  70                  75                  80  


Pro Pro Glu Asp Leu Val Gln Thr Arg Cys Glu Met Glu Lys Tyr Leu 
                85                  90                  95      


Thr Pro Gln Leu Pro Pro Val Pro Ile Ile Pro Glu His Lys Lys Tyr 
            100                 105                 110         


Arg Arg Asp Ser Ala Ser Val Val Asp Gln Phe Phe Thr Asp Thr Glu 
        115                 120                 125             


Gly Leu Pro Tyr Ser Ile Asn Met Asn Val Phe Leu Pro Asp Ile Thr 
    130                 135                 140                 


His Leu Arg Thr Gly Leu Tyr Lys Ser Gln Arg Pro Cys Val Thr His 
145                 150                 155                 160 


Ile Lys Thr Glu Pro Val Ala Ile Phe Ser His Gln Ser Glu Thr Thr 
                165                 170                 175     


Ala Pro Pro Pro Ala Pro Thr Gln Ala Leu Pro Glu Phe Thr Ser Ile 
            180                 185                 190         


Phe Ser Ser His Gln Thr Ala Ala Pro Glu Val Asn Asn Ile Phe Ile 
        195                 200                 205             


Lys Gln Glu Leu Pro Thr Pro Asp Leu His Leu Ser Val Pro Thr Gln 
    210                 215                 220                 


Gln Gly His Leu Tyr Gln Leu Leu Asn Thr Pro Asp Leu Asp Met Pro 
225                 230                 235                 240 


Ser Ser Thr Asn Gln Thr Ala Ala Met Asp Thr Leu Asn Val Ser Met 
                245                 250                 255     


Ser Ala Ala Met Ala Gly Leu Asn Thr His Thr Ser Ala Val Pro Gln 
            260                 265                 270         


Thr Ala Val Lys Gln Phe Gln Gly Met Pro Pro Cys Thr Tyr Thr Met 
        275                 280                 285             


Pro Ser Gln Phe Leu Pro Gln Gln Ala Thr Tyr Phe Pro Pro Ser Pro 
    290                 295                 300                 


Pro Ser Ser Glu Pro Gly Ser Pro Asp Arg Gln Ala Glu Met Leu Gln 
305                 310                 315                 320 


Asn Leu Thr Pro Pro Pro Ser Tyr Ala Ala Thr Ile Ala Ser Lys Leu 
                325                 330                 335     


Ala Ile His Asn Pro Asn Leu Pro Thr Thr Leu Pro Val Asn Ser Gln 
            340                 345                 350         


Asn Ile Gln Pro Val Arg Tyr Asn Arg Arg Ser Asn Pro Asp Leu Glu 
        355                 360                 365             


Lys Arg Arg Ile His Tyr Cys Asp Tyr Pro Gly Cys Thr Lys Val Tyr 
    370                 375                 380                 


Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Thr Trp Glu Gly Cys Asp Trp Arg Phe Ala Arg 
                405                 410                 415     


Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Ala Lys Pro 
            420                 425                 430         


Phe Gln Cys Gly Val Cys Asn Arg Ser Phe Ser Arg Ser Asp His Leu 
        435                 440                 445             


Ala Leu His Met Lys Arg His Gln Asn 
    450                 455         


<210>  9948
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__AAF18307

<400>  9948
auggcuacaa gggugcugag caugagcgcc cgccugggac ccgugcccca gccgccggcg       60

ccgcaggacg agccgguguu cgcgcagcuc aagccggugc ugggcgccgc gaauccggcc      120

cgcgacgcgg cgcucuuccc cggcgaggag cugaagcacg cgcaccaccg cccgcaggcg      180

cagcccgcgc ccgcgcaggc cccgcagccg gcccagccgc ccgccaccgg cccgcggcug      240

ccuccagagg accuggucca aacaagaugu gaaauggaga aguaucugac accucagcuu      300

ccuccaguuc cuauaauucc agagcauaaa aaguauagac gagacagugc cucagucgua      360

gaccaguucu ucacugacac ugaaggguua ccuuacagua ucaacaugaa cgucuuccuc      420

ccugacauca cucaccugag aacuggccuc uacaaauccc agagaccgug cguaacacac      480

aucaagacag aaccuguugc cauuuucagc caccagagug aaacgacugc cccuccuccg      540

gccccgaccc aggcccuccc ugaguucacc aguauauuca gcucacacca gaccgcagcu      600

ccagagguga acaauauuuu caucaaacaa gaacuuccua caccagaucu ucaucuuucu      660

gucccuaccc agcagggcca ccuguaccag cuacugaaua caccggaucu agauaugccc      720

aguucuacaa aucagacagc agcaauggac acucuuaaug uuucuauguc agcugccaug      780

gcaggccuua acacacacac cucugcuguu ccgcagacug cagugaaaca auuccagggc      840

augcccccuu gcacauacac aaugccaagu caguuucuuc cacaacaggc cacuuacuuu      900

cccccgucac caccaagcuc agagccugga aguccagaua gacaagcaga gaugcuccag      960

aauuuaaccc caccuccauc cuaugcugcu acaauugcuu cuaaacuggc aauucacaau     1020

ccaaauuuac ccaccacccu gccaguuaac ucacaaaaca uccaaccugu cagauacaau     1080

agaaggagua accccgauuu ggagaaacga cgcauccacu acugcgauua cccugguugc     1140

acaaaaguuu auaccaaguc uucucauuua aaagcucacc ugaggacuca cacuggugaa     1200

aagccauaca aguguaccug ggaaggcugc gacuggaggu ucgcgcgauc ggaugagcug     1260

acccgccacu accggaagca cacaggcgcc aagcccuucc agugcggggu gugcaaccgc     1320

agcuucucgc gcucugacca ccuggcccug cauaugaaga ggcaccagaa cuga           1374


<210>  9949
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf5__Homo_sapiens__AAF18307

<400>  9949
auggccaccc gcgugcugag cauguccgcc cggcucggcc ccgucccgca gccgcccgcg       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggggccgc caaccccgcc      120

cgcgacgcgg cccucuuccc cggcgaggag cugaagcacg cccaccaccg gccgcaggcc      180

cagcccgcgc ccgcccaggc gccccagccg gcccagccgc ccgccaccgg gccccgccug      240

ccgcccgagg accucgucca gacgcggugc gagauggaga aguaccugac gccccagcug      300

ccgcccgugc ccaucauccc cgagcacaag aaguaccgcc gggacagcgc cuccgugguc      360

gaccaguucu ucaccgacac cgagggccuc cccuacagca ucaacaugaa cguguuccug      420

cccgacauca cccaccuccg caccgggcug uacaaguccc agcggcccug cgugacccac      480

aucaagaccg agcccgucgc caucuucagc caccaguccg agacgaccgc gcccccgccc      540

gcccccaccc aggcccugcc ggaguucacc agcaucuucu ccagccacca gacggccgcc      600

cccgagguga acaacaucuu caucaagcag gagcugccca cccccgaccu ccaccugucc      660

gugccgaccc agcagggcca ccuguaccag cuccugaaca cccccgaccu ggacaugccc      720

agcuccacga accagaccgc cgccauggac acccucaacg ucagcauguc cgccgcgaug      780

gccggccuga acacccacac gagcgccgug ccccagaccg ccgugaagca guuccagggg      840

augccgcccu gcaccuacac caugcccucc caguuccugc cccagcaggc cacguacuuc      900

ccgcccagcc cgcccuccag cgagcccggc agccccgacc gccaggcgga gaugcuccag      960

aaccugaccc cgccgcccuc cuacgccgcc accaucgcca gcaagcuggc gauccacaac     1020

cccaaccucc ccaccacgcu gcccgucaac ucccagaaca uccagcccgu gcgguacaac     1080

cgccggagca accccgaccu ggagaagcgc cggauccacu acugcgacua ccccgggugc     1140

accaaggugu acaccaaguc cagccaccuc aaggcccacc uccgcaccca cacgggcgag     1200

aagccguaca agugcaccug ggaggggugc gacuggcggu ucgcccgcuc cgacgagcug     1260

acccggcacu accgcaagca caccggcgcc aagcccuucc agugcggcgu cugcaaccgg     1320

agcuucuccc gcagcgacca ccuggcccug cacaugaagc gccaccagaa cuga           1374


<210>  9950
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf5__Homo_sapiens__AAF18307

<400>  9950
auggccaccc gcguccucuc cauguccgcc cgccucggcc ccguccccca gccccccgcc       60

ccccaggacg agcccgucuu cgcccagcuc aagcccgucc ucggcgccgc caaccccgcc      120

cgcgacgccg cccucuuccc cggcgaggag cucaagcacg cccaccaccg cccccaggcc      180

cagcccgccc ccgcccaggc cccccagccc gcccagcccc ccgccaccgg cccccgccuc      240

ccccccgagg accucgucca gacccgcugc gagauggaga aguaccucac cccccagcuc      300

ccccccgucc ccaucauccc cgagcacaag aaguaccgcc gcgacuccgc cuccgucguc      360

gaccaguucu ucaccgacac cgagggccuc cccuacucca ucaacaugaa cgucuuccuc      420

cccgacauca cccaccuccg caccggccuc uacaaguccc agcgccccug cgucacccac      480

aucaagaccg agcccgucgc caucuucucc caccaguccg agaccaccgc cccccccccc      540

gcccccaccc aggcccuccc cgaguucacc uccaucuucu ccucccacca gaccgccgcc      600

cccgagguca acaacaucuu caucaagcag gagcucccca cccccgaccu ccaccucucc      660

guccccaccc agcagggcca ccucuaccag cuccucaaca cccccgaccu cgacaugccc      720

uccuccacca accagaccgc cgccauggac acccucaacg ucuccauguc cgccgccaug      780

gccggccuca acacccacac cuccgccguc ccccagaccg ccgucaagca guuccagggc      840

augccccccu gcaccuacac caugcccucc caguuccucc cccagcaggc caccuacuuc      900

ccccccuccc cccccuccuc cgagcccggc ucccccgacc gccaggccga gaugcuccag      960

aaccucaccc ccccccccuc cuacgccgcc accaucgccu ccaagcucgc cauccacaac     1020

cccaaccucc ccaccacccu ccccgucaac ucccagaaca uccagcccgu ccgcuacaac     1080

cgccgcucca accccgaccu cgagaagcgc cgcauccacu acugcgacua ccccggcugc     1140

accaaggucu acaccaaguc cucccaccuc aaggcccacc uccgcaccca caccggcgag     1200

aagcccuaca agugcaccug ggagggcugc gacuggcgcu ucgcccgcuc cgacgagcuc     1260

acccgccacu accgcaagca caccggcgcc aagcccuucc agugcggcgu cugcaaccgc     1320

uccuucuccc gcuccgacca ccucgcccuc cacaugaagc gccaccagaa cuga           1374


<210>  9951
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf5__Homo_sapiens__AAF18307

<400>  9951
auggccacca gagugcugag cauguccgcu aggcucggcc ccgucccuca gccaccggca       60

ccccaagacg agccuguuuu cgcccagcuu aagccagugc ugggggcggc uaaccccgcc      120

cgggaugcag ccuuguuucc uggagaagag uuaaaacacg cucaucaccg cccacaggca      180

cagcccgccc cugcucaagc cccacagccg gcgcagcccc cugcaacagg uccacgacug      240

cccccugaag accuaguaca gacucguugc gagauggaaa aguaccucac gccacaacug      300

cccccggugc cuaucauucc cgagcauaaa aaguauagaa gggauucugc cucagucgug      360

gaccaguucu uuaccgauac agagggccuu ccauacagua uaaauaugaa cguuuuccug      420

ccugacauca cucacuugcg gaccgggcuc uauaaaagcc agcgccccug ugugacacau      480

auuaagaccg aaccagucgc uaucuuuucc caccagucug agacuacagc acccccucca      540

gccccgaccc aagcucugcc cgaauuuacg ucgauuuucu caagccacca gacugccgcg      600

ccugagguga auaacaucuu cauaaagcag gagcugccaa cccccgaucu ccauuuaagu      660

guaccuacac aacagggaca ccuguaccag cuuuugaaua cuccagaccu ggauaugccc      720

uccucuacca accagacagc cgcaauggac acccuaaaug uuagcauguc cgcugccaug      780

gcuggccuca acacgcauac uucagccgug ccgcaaacag cagucaaaca guuucagggu      840

augccuccau gcaccuauac uaugcccagu caguuccugc cucaacaggc cacauacuuu      900

cccccaagcc cucccucuuc cgaaccaggg ucaccggaua gacaggcuga gaugcuucag      960

aaucugaccc cucccccaag cuaugcggca acgaucgcca guaaguuggc uauucacaac     1020

cccaaucucc cuaccacacu gccagugaac ucucaaaaua uccagcccgu gagguacaac     1080

cggcgcucca auccugacuu agaaaaacga aggauucacu acugugauua uccgggaugc     1140

acuaaggucu acaccaaaag cucgcaucug aaggcccacc ucagaacaca uacuggcgag     1200

aagccauaua aauguaccug ggaaggcugc gacuggcggu ucgcacguuc ugacgagcuu     1260

acacgccacu acagaaagca uaccggggcc aaacccuuuc aguguggagu uugcaacagg     1320

uccuucucac ggagugauca ccuggcuuug cacaugaagc gacaucagaa cuga           1374


<210>  9952
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf5__Homo_sapiens__AAF18307

<400>  9952
auggccacca gagugcugag caugagcgcc agacugggcc ccgugcccca gccccccgcc       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggcgccgc caaccccgcc      120

agagacgccg cccuguuccc cggcgaggag cugaagcacg cccaccacag accccaggcc      180

cagcccgccc ccgcccaggc cccccagccc gcccagcccc ccgccaccgg ccccagacug      240

ccccccgagg accuggugca gaccagaugc gagauggaga aguaccugac cccccagcug      300

ccccccgugc ccaucauccc cgagcacaag aaguacagaa gagacagcgc cagcguggug      360

gaccaguucu ucaccgacac cgagggccug cccuacagca ucaacaugaa cguguuccug      420

cccgacauca cccaccugag aaccggccug uacaagagcc agagacccug cgugacccac      480

aucaagaccg agcccguggc caucuucagc caccagagcg agaccaccgc cccccccccc      540

gcccccaccc aggcccugcc cgaguucacc agcaucuuca gcagccacca gaccgccgcc      600

cccgagguga acaacaucuu caucaagcag gagcugccca cccccgaccu gcaccugagc      660

gugcccaccc agcagggcca ccuguaccag cugcugaaca cccccgaccu ggacaugccc      720

agcagcacca accagaccgc cgccauggac acccugaacg ugagcaugag cgccgccaug      780

gccggccuga acacccacac cagcgccgug ccccagaccg ccgugaagca guuccagggc      840

augccccccu gcaccuacac caugcccagc caguuccugc cccagcaggc caccuacuuc      900

ccccccagcc cccccagcag cgagcccggc agccccgaca gacaggccga gaugcugcag      960

aaccugaccc ccccccccag cuacgccgcc accaucgcca gcaagcuggc cauccacaac     1020

cccaaccugc ccaccacccu gcccgugaac agccagaaca uccagcccgu gagauacaac     1080

agaagaagca accccgaccu ggagaagaga agaauccacu acugcgacua ccccggcugc     1140

accaaggugu acaccaagag cagccaccug aaggcccacc ugagaaccca caccggcgag     1200

aagcccuaca agugcaccug ggagggcugc gacuggagau ucgccagaag cgacgagcug     1260

accagacacu acagaaagca caccggcgcc aagcccuucc agugcggcgu gugcaacaga     1320

agcuucagca gaagcgacca ccuggcccug cacaugaaga gacaccagaa cuga           1374


<210>  9953
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf5__Homo_sapiens__AAF18307

<400>  9953
auggccacca gagugcugag cauguccgcu cggcucggcc ccgucccuca gccgcccgcc       60

ccucaagacg agcccguuuu cgcgcagcug aagccugugc uuggggcugc caaccccgcc      120

cgcgaugcug cccuguuucc uggagaagaa cucaaacacg cucaucacag accgcaggcc      180

cagcccgcgc cugcccaagc uccccagccu gcccagcccc cggcuacagg cccucggcug      240

cccccugaag accuugugca gacgcgcugc gagauggaaa aguaccugac accccaacug      300

cccccugucc cgaucauucc cgagcauaaa aaguauagac gggauucugc cagcgugguu      360

gaccaguucu uuaccgauac cgaggggcug ccuuacucca ucaauaugaa cguguuccug      420

cccgacauua cacaccuccg caccggacug uauaaaucuc agagaccuug ugucacacau      480

aucaagaccg aacccguggc gauuuuuagc caccaguccg agacgaccgc cccgccuccc      540

gcuccuacac aagcccuucc cgaguucacc ucuaucuuua gcucccacca gacagcugcc      600

ccugagguua auaacaucuu cauuaagcag gagcugccca ccccggaucu ccaucugagc      660

gugccuacgc aacagggcca ccuuuaccag cugcucaaua cacccgaccu ggauaugccc      720

ucuuccacca accagacagc cgcuauggac acccugaaug ucagcauguc ugcggccaug      780

gcugggcuca acacccauac auccgccgug ccucaaacgg ccgugaaaca guuucaggga      840

augccgcccu gcaccuauac aaugccuagc caguuccugc cccaacaggc uaccuacuuu      900

ccucccucuc cucccuccag cgaaccgggc uccccugauc ggcaggccga gaugcuucag      960

aaucugacac ccccucccuc uuaugcggcu accaucgcca gcaagcucgc cauucacaac     1020

ccgaaucugc cuacgacacu ucccgucaac ucccaaaaua uccagccugu ucgcuacaac     1080

agacggagca aucccgaccu ggaaaaacgc cggauucacu acugugauua ucccggcugc     1140

accaaggugu acaccaaauc uucccaucuc aaggcucacc ucagaacaca uaccggggag     1200

aagccuuaua aauguacaug ggaaggaugc gacuggcgcu ucgccagaag cgacgagcug     1260

acgcggcacu acagaaagca uaccggcgcu aaaccguuuc aguguggggu gugcaaccgc     1320

ucuuucagcc gguccgauca ccucgcccug cacaugaaga gacaucagaa cuga           1374


<210>  9954
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf5__Homo_sapiens__AAF18307

<400>  9954
auggcuacca gaguacuauc aaugucagca agauuaggac ccguuccaca accaccagca       60

ccacaagacg aaccaguauu cgcacaauua aaaccaguac uaggagcagc caacccagca      120

agagacgcag ccuuauuccc aggcgaagaa cuaaaacaug cacaucaccg accacaagcu      180

caacccgcac cagcccaagc cccacaacca gcacaaccac cagcaaccgg accaagacua      240

ccaccagaag accuaguaca aacacgcugc gaaauggaaa aauaccuaac accacaacua      300

ccaccaguuc caauaauacc agaacauaaa aaauaccgua gagauuccgc aucaguagua      360

gaccaauuuu ucacagacac agaaggccua ccauacucca uaaauaugaa uguauucuua      420

ccagacauaa cacacuuacg aacaggccua uauaaaucac aaagacccug cguuacacac      480

auuaaaacag aaccuguagc aauauucuca caccaaucag aaaccacagc cccaccucca      540

gcaccaacac aagcacuacc agaauuuaca ucuauauucu ccucucauca aaccgcagcu      600

ccagaaguua acaacaucuu cauaaaacaa gaacuaccaa cuccagaccu acaccuauca      660

gucccaacac aacaaggaca ccuauaucaa cuacuuaaca cuccagaccu cgacaugcca      720

uccucaacaa aucaaacugc cgcaauggau acuuuaaacg uaucaauguc cgcugccaug      780

gcaggccuaa acacucacac aucagcaguu ccacaaacag ccguaaaaca auuccaagga      840

augccacccu gcaccuacac uaugcccuca caauuuuuac cacaacaagc aacauacuuc      900

ccccccagcc caccauccuc ugaaccagga uccccagaca gacaagcaga aaugcuccaa      960

aaccuuacuc caccacccuc uuaugcagca acaauagcuu caaaacuugc aauccacaau     1020

ccaaaucucc caacuacacu uccaguaaac ucccaaaaua uccaaccagu aagauauaac     1080

agaagaucaa auccagaccu ggaaaaaaga agaauacacu acugcgacua uccaggcugc     1140

acaaaagucu acacaaaauc aucacaccua aaagcacacc uaagaacaca uaccggcgaa     1200

aaaccauaca aauguacaug ggaaggcugu gacuggagau ucgcaagauc agacgaacua     1260

acucgacauu accgcaaaca cacuggagca aaaccauuuc aauguggagu augcaacaga     1320

uccuucucac guucagauca uuuagcacuc cacaugaaaa gacaccaaaa cuaa           1374


<210>  9955
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__Q5T6X2

<400>  9955

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Val Pro 
1               5                   10                  15      


Gln Pro Pro Ala Pro Gln Asp Glu Pro Val Phe Ala Gln Leu Lys Pro 
            20                  25                  30          


Val Leu Gly Ala Ala Asn Pro Ala Arg Asp Ala Ala Leu Phe Pro Gly 
        35                  40                  45              


Glu Glu Leu Lys His Ala His His Arg Pro Gln Ala Gln Pro Ala Pro 
    50                  55                  60                  


Ala Gln Ala Pro Gln Pro Ala Gln Pro Pro Ala Thr Gly Pro Arg Leu 
65                  70                  75                  80  


Pro Pro Glu Asp Leu Val Gln Thr Arg Cys Glu Met Glu Lys Tyr Leu 
                85                  90                  95      


Thr Pro Gln Leu Pro Pro Val Pro Ile Ile Pro Glu His Lys Lys Tyr 
            100                 105                 110         


Arg Arg Asp Ser Ala Ser Val Val Asp Gln Phe Phe Thr Asp Thr Glu 
        115                 120                 125             


Gly Leu Pro Tyr Ser Ile Asn Met Asn Val Phe Leu Pro Asp Ile Thr 
    130                 135                 140                 


His Leu Arg Thr Gly Leu Tyr Lys Ser Gln Arg Pro Cys Val Thr His 
145                 150                 155                 160 


Ile Lys Thr Glu Pro Val Ala Ile Phe Ser His Gln Ser Glu Thr Thr 
                165                 170                 175     


Ala Pro Pro Pro Ala Pro Thr Gln Ala Leu Pro Glu Phe Thr Ser Ile 
            180                 185                 190         


Phe Ser Ser His Gln Thr Ala Ala Pro Glu Val Asn Asn Ile Phe Ile 
        195                 200                 205             


Lys Gln Glu Leu Pro Thr Pro Asp Leu His Leu Ser Val Pro Thr Gln 
    210                 215                 220                 


Gln Gly His Leu Tyr Gln Leu Leu Asn Thr Pro Asp Leu Asp Met Pro 
225                 230                 235                 240 


Ser Ser Thr Asn Gln Thr Ala Ala Met Asp Thr Leu Asn Val Ser Met 
                245                 250                 255     


Ser Ala Ala Met Ala Gly Leu Asn Thr His Thr Ser Ala Val Pro Gln 
            260                 265                 270         


Thr Ala Val Lys Gln Phe Gln Gly Met Pro Pro Cys Thr Tyr Thr Met 
        275                 280                 285             


Pro Ser Gln Phe Leu Pro Gln Gln Ala Thr Tyr Phe Pro Pro Ser Pro 
    290                 295                 300                 


Pro Ser Ser Glu Pro Gly Ser Pro Asp Arg Gln Ala Glu Met Leu Gln 
305                 310                 315                 320 


Asn Leu Thr Pro Pro Pro Ser Tyr Ala Ala Thr Ile Ala Ser Lys Leu 
                325                 330                 335     


Ala Ile His Asn Pro Asn Leu Pro Thr Thr Leu Pro Val Asn Ser Gln 
            340                 345                 350         


Asn Ile Gln Pro Val Arg Tyr Asn Arg Arg Ser Asn Pro Asp Leu Glu 
        355                 360                 365             


Lys Arg Arg Ile His Tyr Cys Asp Tyr Pro Gly Cys Thr Lys Val Tyr 
    370                 375                 380                 


Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Thr Trp Glu Gly Cys Asp Trp Arg Phe Ala Arg 
                405                 410                 415     


Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Ala Lys Pro 
            420                 425                 430         


Phe Gln Cys Gly Val Cys Asn Arg Ser Phe Ser Arg Ser Asp His Leu 
        435                 440                 445             


Ala Leu His Met Lys Arg His Gln Asn 
    450                 455         


<210>  9956
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Klf5__Homo_sapiens__AAP35287

<400>  9956
auggcuacaa gggugcugag caugagcgcc cgccugggac ccgugcccca gccgccggcg       60

ccgcaggacg agccgguguu cgcgcagcuc aagccggugc ugggcgccgc gaauccggcc      120

cgcgacgcgg cgcucuuccc cggcgaggag cugaagcacg cgcaccaccg cccgcaggcg      180

cagcccgcgc ccgcgcaggc cccgcagccg gcccagccgc ccgccaccgg cccgcggcug      240

ccuccagagg accuggucca gacaagaugu gaaauggaga aguaucugac accucagcuu      300

ccuccaguuc cuauaauucc agagcauaaa aaguauagac gagacagugc cucagucgua      360

gaccaguucu ucacugacac ugaaggguua ccuuacagua ucaacaugaa cgucuuccuc      420

ccugacauca cucaccugag aacuggccuc uacaaauccc agagaccgug cguaacacac      480

aucaagacag aaccuguugc cauuuucagc caccagagug aaacgacugc cccuccuccg      540

gccccgaccc aggcccuccc ugaguucacc aguauauuca gcucacacca gaccgcagcu      600

ccagagguga acaauauuuu caucaaacaa gaacuuccua caccagaucu ucaucuuucu      660

gucccuaccc agcagggcca ccuguaccag cuacugaaua caccggaucu agauaugccc      720

aguucuacaa aucagacagc agcaauggac acucuuaaug uuucuauguc agcugccaug      780

gcaggccuua acacacacac cucugcuguu ccgcagacug cagugaaaca auuccagggc      840

augcccccuu gcacauacac aaugccaagu caguuucuuc cacaacaggc cacuuacuuu      900

cccccgucac caccaagcuc agagccugga aguccagaua gacaagcaga gaugcuccag      960

aauuuaaccc caccuccauc cuaugcugcu acaauugcuu cuaaacuggc aauucacaau     1020

ccaaauuuac ccaccacccu gccaguuaac ucacaaaaca uccaaccugu cagauacaau     1080

agaaggagua accccgauuu ggagaaacga cgcauccacu acugcgauua cccugguugc     1140

acaaaaguuu auaccaaguc uucucauuua aaagcucacc ugaggacuca cacuggugaa     1200

aagccauaca aguguaccug ggaaggcugc gacuggaggu ucgcgcgauc ggaugagcug     1260

acccgccacu accggaagca cacaggcgcc aagcccuucc agugcggggu gugcaaccgc     1320

agcuucucgc gcucugacca ccuggcccug cauaugaaga ggcaccagaa cuag           1374


<210>  9957
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Klf5__Homo_sapiens__AAP35287

<400>  9957
auggccaccc gcgugcugag cauguccgcc cggcucggcc ccgucccgca gccgcccgcg       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggggccgc caaccccgcc      120

cgcgacgcgg cccucuuccc cggcgaggag cugaagcacg cccaccaccg gccgcaggcc      180

cagcccgcgc ccgcccaggc gccccagccg gcccagccgc ccgccaccgg gccccgccug      240

ccgcccgagg accucgucca gacgcggugc gagauggaga aguaccugac gccccagcug      300

ccgcccgugc ccaucauccc cgagcacaag aaguaccgcc gggacagcgc cuccgugguc      360

gaccaguucu ucaccgacac cgagggccuc cccuacagca ucaacaugaa cguguuccug      420

cccgacauca cccaccuccg caccgggcug uacaaguccc agcggcccug cgugacccac      480

aucaagaccg agcccgucgc caucuucagc caccaguccg agacgaccgc gcccccgccc      540

gcccccaccc aggcccugcc ggaguucacc agcaucuucu ccagccacca gacggccgcc      600

cccgagguga acaacaucuu caucaagcag gagcugccca cccccgaccu ccaccugucc      660

gugccgaccc agcagggcca ccuguaccag cuccugaaca cccccgaccu ggacaugccc      720

agcuccacga accagaccgc cgccauggac acccucaacg ucagcauguc cgccgcgaug      780

gccggccuga acacccacac gagcgccgug ccccagaccg ccgugaagca guuccagggg      840

augccgcccu gcaccuacac caugcccucc caguuccugc cccagcaggc cacguacuuc      900

ccgcccagcc cgcccuccag cgagcccggc agccccgacc gccaggcgga gaugcuccag      960

aaccugaccc cgccgcccuc cuacgccgcc accaucgcca gcaagcuggc gauccacaac     1020

cccaaccucc ccaccacgcu gcccgucaac ucccagaaca uccagcccgu gcgguacaac     1080

cgccggagca accccgaccu ggagaagcgc cggauccacu acugcgacua ccccgggugc     1140

accaaggugu acaccaaguc cagccaccuc aaggcccacc uccgcaccca cacgggcgag     1200

aagccguaca agugcaccug ggaggggugc gacuggcggu ucgcccgcuc cgacgagcug     1260

acccggcacu accgcaagca caccggcgcc aagcccuucc agugcggcgu cugcaaccgg     1320

agcuucuccc gcagcgacca ccuggcccug cacaugaagc gccaccagaa cuga           1374


<210>  9958
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Klf5__Homo_sapiens__AAP35287

<400>  9958
auggccaccc gcguccucuc cauguccgcc cgccucggcc ccguccccca gccccccgcc       60

ccccaggacg agcccgucuu cgcccagcuc aagcccgucc ucggcgccgc caaccccgcc      120

cgcgacgccg cccucuuccc cggcgaggag cucaagcacg cccaccaccg cccccaggcc      180

cagcccgccc ccgcccaggc cccccagccc gcccagcccc ccgccaccgg cccccgccuc      240

ccccccgagg accucgucca gacccgcugc gagauggaga aguaccucac cccccagcuc      300

ccccccgucc ccaucauccc cgagcacaag aaguaccgcc gcgacuccgc cuccgucguc      360

gaccaguucu ucaccgacac cgagggccuc cccuacucca ucaacaugaa cgucuuccuc      420

cccgacauca cccaccuccg caccggccuc uacaaguccc agcgccccug cgucacccac      480

aucaagaccg agcccgucgc caucuucucc caccaguccg agaccaccgc cccccccccc      540

gcccccaccc aggcccuccc cgaguucacc uccaucuucu ccucccacca gaccgccgcc      600

cccgagguca acaacaucuu caucaagcag gagcucccca cccccgaccu ccaccucucc      660

guccccaccc agcagggcca ccucuaccag cuccucaaca cccccgaccu cgacaugccc      720

uccuccacca accagaccgc cgccauggac acccucaacg ucuccauguc cgccgccaug      780

gccggccuca acacccacac cuccgccguc ccccagaccg ccgucaagca guuccagggc      840

augccccccu gcaccuacac caugcccucc caguuccucc cccagcaggc caccuacuuc      900

ccccccuccc cccccuccuc cgagcccggc ucccccgacc gccaggccga gaugcuccag      960

aaccucaccc ccccccccuc cuacgccgcc accaucgccu ccaagcucgc cauccacaac     1020

cccaaccucc ccaccacccu ccccgucaac ucccagaaca uccagcccgu ccgcuacaac     1080

cgccgcucca accccgaccu cgagaagcgc cgcauccacu acugcgacua ccccggcugc     1140

accaaggucu acaccaaguc cucccaccuc aaggcccacc uccgcaccca caccggcgag     1200

aagcccuaca agugcaccug ggagggcugc gacuggcgcu ucgcccgcuc cgacgagcuc     1260

acccgccacu accgcaagca caccggcgcc aagcccuucc agugcggcgu cugcaaccgc     1320

uccuucuccc gcuccgacca ccucgcccuc cacaugaagc gccaccagaa cuga           1374


<210>  9959
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Klf5__Homo_sapiens__AAP35287

<400>  9959
auggccacca gagugcugag cauguccgcu aggcucggcc ccgucccuca gccaccggca       60

ccccaagacg agccuguuuu cgcccagcuu aagccagugc ugggggcggc uaaccccgcc      120

cgggaugcag ccuuguuucc uggagaagag uuaaaacacg cucaucaccg cccacaggca      180

cagcccgccc cugcucaagc cccacagccg gcgcagcccc cugcaacagg uccacgacug      240

cccccugaag accuaguaca gacucguugc gagauggaaa aguaccucac gccacaacug      300

cccccggugc cuaucauucc cgagcauaaa aaguauagaa gggauucugc cucagucgug      360

gaccaguucu uuaccgauac agagggccuu ccauacagua uaaauaugaa cguuuuccug      420

ccugacauca cucacuugcg gaccgggcuc uauaaaagcc agcgccccug ugugacacau      480

auuaagaccg aaccagucgc uaucuuuucc caccagucug agacuacagc acccccucca      540

gccccgaccc aagcucugcc cgaauuuacg ucgauuuucu caagccacca gacugccgcg      600

ccugagguga auaacaucuu cauaaagcag gagcugccaa cccccgaucu ccauuuaagu      660

guaccuacac aacagggaca ccuguaccag cuuuugaaua cuccagaccu ggauaugccc      720

uccucuacca accagacagc cgcaauggac acccuaaaug uuagcauguc cgcugccaug      780

gcuggccuca acacgcauac uucagccgug ccgcaaacag cagucaaaca guuucagggu      840

augccuccau gcaccuauac uaugcccagu caguuccugc cucaacaggc cacauacuuu      900

cccccaagcc cucccucuuc cgaaccaggg ucaccggaua gacaggcuga gaugcuucag      960

aaucugaccc cucccccaag cuaugcggca acgaucgcca guaaguuggc uauucacaac     1020

cccaaucucc cuaccacacu gccagugaac ucucaaaaua uccagcccgu gagguacaac     1080

cggcgcucca auccugacuu agaaaaacga aggauucacu acugugauua uccgggaugc     1140

acuaaggucu acaccaaaag cucgcaucug aaggcccacc ucagaacaca uacuggcgag     1200

aagccauaua aauguaccug ggaaggcugc gacuggcggu ucgcacguuc ugacgagcuu     1260

acacgccacu acagaaagca uaccggggcc aaacccuuuc aguguggagu uugcaacagg     1320

uccuucucac ggagugauca ccuggcuuug cacaugaagc gacaucagaa cuga           1374


<210>  9960
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Klf5__Homo_sapiens__AAP35287

<400>  9960
auggccacca gagugcugag caugagcgcc agacugggcc ccgugcccca gccccccgcc       60

ccccaggacg agcccguguu cgcccagcug aagcccgugc ugggcgccgc caaccccgcc      120

agagacgccg cccuguuccc cggcgaggag cugaagcacg cccaccacag accccaggcc      180

cagcccgccc ccgcccaggc cccccagccc gcccagcccc ccgccaccgg ccccagacug      240

ccccccgagg accuggugca gaccagaugc gagauggaga aguaccugac cccccagcug      300

ccccccgugc ccaucauccc cgagcacaag aaguacagaa gagacagcgc cagcguggug      360

gaccaguucu ucaccgacac cgagggccug cccuacagca ucaacaugaa cguguuccug      420

cccgacauca cccaccugag aaccggccug uacaagagcc agagacccug cgugacccac      480

aucaagaccg agcccguggc caucuucagc caccagagcg agaccaccgc cccccccccc      540

gcccccaccc aggcccugcc cgaguucacc agcaucuuca gcagccacca gaccgccgcc      600

cccgagguga acaacaucuu caucaagcag gagcugccca cccccgaccu gcaccugagc      660

gugcccaccc agcagggcca ccuguaccag cugcugaaca cccccgaccu ggacaugccc      720

agcagcacca accagaccgc cgccauggac acccugaacg ugagcaugag cgccgccaug      780

gccggccuga acacccacac cagcgccgug ccccagaccg ccgugaagca guuccagggc      840

augccccccu gcaccuacac caugcccagc caguuccugc cccagcaggc caccuacuuc      900

ccccccagcc cccccagcag cgagcccggc agccccgaca gacaggccga gaugcugcag      960

aaccugaccc ccccccccag cuacgccgcc accaucgcca gcaagcuggc cauccacaac     1020

cccaaccugc ccaccacccu gcccgugaac agccagaaca uccagcccgu gagauacaac     1080

agaagaagca accccgaccu ggagaagaga agaauccacu acugcgacua ccccggcugc     1140

accaaggugu acaccaagag cagccaccug aaggcccacc ugagaaccca caccggcgag     1200

aagcccuaca agugcaccug ggagggcugc gacuggagau ucgccagaag cgacgagcug     1260

accagacacu acagaaagca caccggcgcc aagcccuucc agugcggcgu gugcaacaga     1320

agcuucagca gaagcgacca ccuggcccug cacaugaaga gacaccagaa cuga           1374


<210>  9961
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Klf5__Homo_sapiens__AAP35287

<400>  9961
auggccacca gagugcugag cauguccgcu cggcucggcc ccgucccuca gccgcccgcc       60

ccucaagacg agcccguuuu cgcgcagcug aagccugugc uuggggcugc caaccccgcc      120

cgcgaugcug cccuguuucc uggagaagaa cucaaacacg cucaucacag accgcaggcc      180

cagcccgcgc cugcccaagc uccccagccu gcccagcccc cggcuacagg cccucggcug      240

cccccugaag accuugugca gacgcgcugc gagauggaaa aguaccugac accccaacug      300

cccccugucc cgaucauucc cgagcauaaa aaguauagac gggauucugc cagcgugguu      360

gaccaguucu uuaccgauac cgaggggcug ccuuacucca ucaauaugaa cguguuccug      420

cccgacauua cacaccuccg caccggacug uauaaaucuc agagaccuug ugucacacau      480

aucaagaccg aacccguggc gauuuuuagc caccaguccg agacgaccgc cccgccuccc      540

gcuccuacac aagcccuucc cgaguucacc ucuaucuuua gcucccacca gacagcugcc      600

ccugagguua auaacaucuu cauuaagcag gagcugccca ccccggaucu ccaucugagc      660

gugccuacgc aacagggcca ccuuuaccag cugcucaaua cacccgaccu ggauaugccc      720

ucuuccacca accagacagc cgcuauggac acccugaaug ucagcauguc ugcggccaug      780

gcugggcuca acacccauac auccgccgug ccucaaacgg ccgugaaaca guuucaggga      840

augccgcccu gcaccuauac aaugccuagc caguuccugc cccaacaggc uaccuacuuu      900

ccucccucuc cucccuccag cgaaccgggc uccccugauc ggcaggccga gaugcuucag      960

aaucugacac ccccucccuc uuaugcggcu accaucgcca gcaagcucgc cauucacaac     1020

ccgaaucugc cuacgacacu ucccgucaac ucccaaaaua uccagccugu ucgcuacaac     1080

agacggagca aucccgaccu ggaaaaacgc cggauucacu acugugauua ucccggcugc     1140

accaaggugu acaccaaauc uucccaucuc aaggcucacc ucagaacaca uaccggggag     1200

aagccuuaua aauguacaug ggaaggaugc gacuggcgcu ucgccagaag cgacgagcug     1260

acgcggcacu acagaaagca uaccggcgcu aaaccguuuc aguguggggu gugcaaccgc     1320

ucuuucagcc gguccgauca ccucgcccug cacaugaaga gacaucagaa cuga           1374


<210>  9962
<211>  1374
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Klf5__Homo_sapiens__AAP35287

<400>  9962
auggcaacaa gaguccucuc caugucagca agacuaggac ccguacccca acccccagcc       60

ccacaagacg aaccaguauu cgcacaacua aaacccgucc uaggugcagc aaacccagcu      120

cgagaugccg ccuuauuccc aggugaagaa uuaaaacacg cacaucaccg accacaagcu      180

caaccugcac cagcacaagc accacaaccc gcacaacccc ccgcaacagg cccccgacua      240

ccucccgaag accucguaca aaccagaugc gaaauggaaa aauaccuaac cccccaacua      300

ccucccguuc cuauaauccc cgaacacaaa aaauacagaa gagacucagc aucaguuguu      360

gaucaauucu uuacagacac cgaaggacua cccuauucua ucaauaugaa cgucuuucuu      420

ccagauauaa cucauuuaag aacagguuua uacaaaucac aacgacccug cguuacccac      480

auuaaaacag aacccguagc aauauucuca caccaaucag aaacaaccgc accaccccca      540

gcaccaacac aagcauuacc agaauucaca uccauuuuuu ccucucauca aaccgccgcc      600

ccagaaguaa acaacauauu cauaaaacaa gaauuaccaa cuccagaucu acaccuaucc      660

guaccaaccc aacaaggaca cuuauaucaa cuacuaaaca caccagaccu ugacaugcca      720

uccucuacua aucaaacagc cgcaauggac acacuaaacg uaucaauguc ugccgcaaug      780

gcaggacuaa auacccacac auccgcagua ccacaaaccg cuguaaaaca auuucaagga      840

augccacccu gcaccuauac aaugccauca caauuccuuc cacaacaagc aaccuacuuc      900

ccaccaucac cuccauccuc agaaccagga ucaccagacc gacaagcaga aaugcuccaa      960

aaccucaccc ccccacccuc cuacgccgca acaauagccu caaaacuagc aauccacaac     1020

cccaaccuuc ccacaaccuu acccguaaac ucccaaaaca uucaaccagu acgcuacaac     1080

cgaagaucaa aucccgaccu agaaaaaaga agaauacacu acugugacua cccagguugu     1140

acuaaaguau auacaaaauc gucacaccua aaagcacauu uacgaacaca uaccggagaa     1200

aaaccuuaca aaugcacaug ggaagguugu gauuggagau ucgcucgauc cgaugaacua     1260

acaagacacu accgaaaaca cacaggcgca aaaccauucc aaugcggcgu augcaacaga     1320

ucauucucaa gauccgauca ccuugcacuu cacaugaaac gacaccaaaa cuaa           1374


<210>  9963
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LIN28__Homo_sapiens__Q9H9Z2

<400>  9963

Met Gly Ser Val Ser Asn Gln Gln Phe Ala Gly Gly Cys Ala Lys Ala 
1               5                   10                  15      


Ala Glu Glu Ala Pro Glu Glu Ala Pro Glu Asp Ala Ala Arg Ala Ala 
            20                  25                  30          


Asp Glu Pro Gln Leu Leu His Gly Ala Gly Ile Cys Lys Trp Phe Asn 
        35                  40                  45              


Val Arg Met Gly Phe Gly Phe Leu Ser Met Thr Ala Arg Ala Gly Val 
    50                  55                  60                  


Ala Leu Asp Pro Pro Val Asp Val Phe Val His Gln Ser Lys Leu His 
65                  70                  75                  80  


Met Glu Gly Phe Arg Ser Leu Lys Glu Gly Glu Ala Val Glu Phe Thr 
                85                  90                  95      


Phe Lys Lys Ser Ala Lys Gly Leu Glu Ser Ile Arg Val Thr Gly Pro 
            100                 105                 110         


Gly Gly Val Phe Cys Ile Gly Ser Glu Arg Arg Pro Lys Gly Lys Ser 
        115                 120                 125             


Met Gln Lys Arg Arg Ser Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly 
    130                 135                 140                 


Leu Asp His His Ala Lys Glu Cys Lys Leu Pro Pro Gln Pro Lys Lys 
145                 150                 155                 160 


Cys His Phe Cys Gln Ser Ile Ser His Met Val Ala Ser Cys Pro Leu 
                165                 170                 175     


Lys Ala Gln Gln Gly Pro Ser Ala Gln Gly Lys Pro Thr Tyr Phe Arg 
            180                 185                 190         


Glu Glu Glu Glu Glu Ile His Ser Pro Thr Leu Leu Pro Glu Ala Gln 
        195                 200                 205             


Asn 
    


<210>  9964
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  LIN28__Homo_sapiens__AAH28566

<400>  9964
augggcuccg uguccaacca gcaguuugca gguggcugcg ccaaggcggc agaagaggcg       60

cccgaggagg cgccggagga cgcggcccgg gcggcggacg agccucagcu gcugcacggu      120

gcgggcaucu guaagugguu caacgugcgc augggguucg gcuuccuguc caugaccgcc      180

cgcgccgggg ucgcgcucga ccccccagug gaugucuuug ugcaccagag uaagcugcac      240

auggaagggu uccggagcuu gaaggagggu gaggcagugg aguucaccuu uaagaaguca      300

gccaaggguc uggaauccau ccgugucacc ggaccuggug gaguauucug uauugggagu      360

gagaggcggc caaaaggaaa gagcaugcag aagcgcagau caaaaggaga caggugcuac      420

aacuguggag gucuagauca ucaugccaag gaaugcaagc ugccacccca gcccaagaag      480

ugccacuucu gccagagcau cagccauaug guagccucau guccgcugaa ggcccagcag      540

ggcccuagug cacagggaaa gccaaccuac uuucgagagg aagaagaaga aauccacagc      600

ccuacccugc ucccggaggc acagaauuga                                       630


<210>  9965
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       LIN28__Homo_sapiens__AAH28566

<400>  9965
augggcagcg uguccaacca gcaguucgcc gggggcugcg ccaaggcggc cgaggaggcc       60

cccgaggagg ccccggagga cgccgcgcgc gccgccgacg agccccagcu gcuccacggg      120

gccggcaucu gcaagugguu caacguccgg augggguucg gcuuccugag caugaccgcg      180

cgcgccggcg uggcccugga cccgcccgug gacgucuucg ugcaccaguc caagcuccac      240

auggaggggu uccggagccu gaaggagggc gaggccgugg aguucaccuu caagaagucc      300

gccaaggggc uggagagcau ccgcgucacg ggccccgggg gcguguucug caucggcucc      360

gagcggcgcc ccaagggcaa gagcaugcag aagcggcgcu ccaaggggga ccggugcuac      420

aacugcgggg gccucgacca ccacgcgaag gagugcaagc ugccgcccca gcccaagaag      480

ugccacuucu gccagagcau cucccacaug guggccagcu gcccccugaa ggcccagcag      540

ggccccuccg cccaggggaa gcccaccuac uuccgcgagg aggaggagga gauccacagc      600

ccgacccucc ugcccgaggc ccagaacuga                                       630


<210>  9966
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       LIN28__Homo_sapiens__AAH28566

<400>  9966
augggcuccg ucuccaacca gcaguucgcc ggcggcugcg ccaaggccgc cgaggaggcc       60

cccgaggagg cccccgagga cgccgcccgc gccgccgacg agccccagcu ccuccacggc      120

gccggcaucu gcaagugguu caacguccgc augggcuucg gcuuccucuc caugaccgcc      180

cgcgccggcg ucgcccucga cccccccguc gacgucuucg uccaccaguc caagcuccac      240

auggagggcu uccgcucccu caaggagggc gaggccgucg aguucaccuu caagaagucc      300

gccaagggcc ucgaguccau ccgcgucacc ggccccggcg gcgucuucug caucggcucc      360

gagcgccgcc ccaagggcaa guccaugcag aagcgccgcu ccaagggcga ccgcugcuac      420

aacugcggcg gccucgacca ccacgccaag gagugcaagc ucccccccca gcccaagaag      480

ugccacuucu gccaguccau cucccacaug gucgccuccu gcccccucaa ggcccagcag      540

ggccccuccg cccagggcaa gcccaccuac uuccgcgagg aggaggagga gauccacucc      600

cccacccucc uccccgaggc ccagaacuga                                       630


<210>  9967
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       LIN28__Homo_sapiens__AAH28566

<400>  9967
augggcagcg uguccaacca gcaauucgcc gggggaugcg cuaaggcagc cgaggaagcg       60

cccgaggaag cuccugagga cgccgcaaga gccgcugaug aaccacagcu gcuccacggu      120

gcaggcaucu guaaaugguu uaaugucagg augggguucg gauuucuuuc uaugaccgcc      180

cgggcuggcg uugcccugga cccgcccgug gauguauucg ugcaucaguc aaaguugcac      240

auggaggguu uucgcaguuu aaaagagggg gaagcggucg aguucacauu uaagaaaagc      300

gcaaagggac uggaauccau ucgagugacu ggcccuggcg ggguuuucug cauaggaucu      360

gagcguagac caaaggguaa aucgaugcag aagaggcggu caaaaggcga ccgcuguuac      420

aacugcgggg gacuagauca ucacgccaag gaguguaaac ugcccccuca accaaagaag      480

ugccauuuuu gucagagcau cagucacaug guggcuuccu gcccccucaa agcccagcag      540

ggcccuucug cacaagguaa gccaacguau uucagagaag aggaagagga aauucacagc      600

ccgacccuuc ugcccgaggc ucagaauuga                                       630


<210>  9968
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       LIN28__Homo_sapiens__AAH28566

<400>  9968
augggcagcg ugagcaacca gcaguucgcc ggcggcugcg ccaaggccgc cgaggaggcc       60

cccgaggagg cccccgagga cgccgccaga gccgccgacg agccccagcu gcugcacggc      120

gccggcaucu gcaagugguu caacgugaga augggcuucg gcuuccugag caugaccgcc      180

agagccggcg uggcccugga cccccccgug gacguguucg ugcaccagag caagcugcac      240

auggagggcu ucagaagccu gaaggagggc gaggccgugg aguucaccuu caagaagagc      300

gccaagggcc uggagagcau cagagugacc ggccccggcg gcguguucug caucggcagc      360

gagagaagac ccaagggcaa gagcaugcag aagagaagaa gcaagggcga cagaugcuac      420

aacugcggcg gccuggacca ccacgccaag gagugcaagc ugccccccca gcccaagaag      480

ugccacuucu gccagagcau cagccacaug guggccagcu gcccccugaa ggcccagcag      540

ggccccagcg cccagggcaa gcccaccuac uucagagagg aggaggagga gauccacagc      600

cccacccugc ugcccgaggc ccagaacuga                                       630


<210>  9969
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       LIN28__Homo_sapiens__AAH28566

<400>  9969
augggcagcg uguccaacca gcaauucgcc gggggaugcg cuaaggccgc ggaggaagcu       60

cccgaggaag ccccugagga cgccgcuaga gccgcugaug aaccgcagcu gcuccacggc      120

gccgggaucu guaaaugguu uaauguccgg augggauucg gcuuucuguc uaugaccgcg      180

cgcgccgggg uugcucuuga ucccccugug gacguguucg uccaucagag caagcugcac      240

auggagggau uuagaucccu caaagagggc gaagccgugg aguucacauu uaagaaaucu      300

gcuaagggcc uggaaagcau ucggguuacg gggcccggag gcguguucug caucgggucc      360

gagcgcagac cuaagggaaa aucuaugcag aagcggcgca gcaaaggcga cagauguuac      420

aacugcgggg gacuugauca ucacgccaag gaguguaaac ugcccccuca accgaagaag      480

ugccauuuuu gucaguccau uagccacaug gucgcgucuu gcccccucaa agcccagcag      540

ggcccuuccg cucaaggcaa gcccaccuau uuccgggaag aggaagagga aauccacagc      600

ccuacacugc ugcccgaggc ccagaauuga                                       630


<210>  9970
<211>  630
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       LIN28__Homo_sapiens__AAH28566

<400>  9970
augggaucag uaucaaauca acaauuugca ggaggaugug caaaagcagc agaagaagca       60

ccagaagaag caccagaaga ugcagcaaga gcagcagaug aaccacaauu acuacaugga      120

gcaggaauau gcaaaugguu uaacguaaga augggauuug gauuucuauc aaugacagca      180

agagcaggag ucgcacuaga uccaccagua gacguauuug uacaucaaag uaaauuacau      240

auggaaggau ucaggaguuu aaaagaagga gaagcaguag aauuuacauu uaaaaaaagc      300

gcaaaaggac uagaaagcau aagaguuaca ggaccaggag gaguauucug uauaggaagc      360

gaaagaagac caaaaggaaa aagcaugcaa aaaagaagaa gcaaaggaga uagauguuac      420

aauugcggag gauuagacca ucacgcaaaa gaaugcaaau uaccaccaca accaaaaaaa      480

ugucacuuuu gccaaaguau aagccacaug guagcaucau gcccauuaaa agcacaacaa      540

ggaccaucag cacaaggaaa accaacauac uuuagagaag aagaagaaga aauacauagc      600

ccaacauuac uaccagaagc acaaaauuaa                                       630


<210>  9971
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  L-myc__Homo_sapiens__A0A0A0N0L0

<400>  9971

Met Asp Tyr Asp Ser Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly 
1               5                   10                  15      


Glu Asp Phe Tyr Arg Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys 
            20                  25                  30          


Phe Glu Leu Val Pro Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly 
        35                  40                  45              


Pro Gly Ala Gly Asp Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp 
    50                  55                  60                  


Pro Gly Gly Cys Thr Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys 
65                  70                  75                  80  


Gly Trp Gly Arg Asn Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp 
                85                  90                  95      


Ser Gly Phe Ser Ala Ser Lys Pro Ala Thr Arg Arg Pro Pro Pro Pro 
            100                 105                 110         


Val Arg Trp Ala Asn Pro Arg Pro Arg Pro Ala Pro Gly Pro Arg Ala 
        115                 120                 125             


Gln Ala Thr Arg Arg Met Lys Lys Leu Met Leu 
    130                 135                 


<210>  9972
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  L-myc__Homo_sapiens__AER93388

<400>  9972
auggacuacg acucguacca gcacuauuuc uacgacuaug acugcgggga ggauuucuac       60

cgcuccacgg cgcccagcga ggacaucugg aagaaauucg agcuggugcc aucgcccccc      120

acgucgccgc ccuggggcuu gggucccggc gcaggggacc cggcccccgg gauugguccc      180

ccggagccgu ggcccggagg gugcaccgga gacgaagcgg aaucccgggg ccacucgaaa      240

ggcuggggca ggaacuacgc cuccaucaua cgccgugacu gcauguggag cggcuucuca      300

gccucgaagc cggcaacccg gcgcccgccg cccccugucc gcugggcgaa cccaagaccc      360

aggccugcuc cggguccgag agcccaagcg acucggagaa ugaagaaauu gauguuguga      420


<210>  9973
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       L-myc__Homo_sapiens__AER93388

<400>  9973
auggacuacg acagcuacca gcacuacuuc uacgacuacg acugcggcga ggacuucuac       60

cgcuccaccg cccccagcga ggacaucugg aagaaguucg agcuggugcc cuccccgccc      120

accagcccgc ccugggggcu cggccccggg gccggcgacc ccgcgcccgg gaucggcccg      180

cccgagcccu ggcccggcgg gugcacgggc gacgaggccg agucccgggg gcacagcaag      240

ggcugggggc gcaacuacgc cuccaucauc cggcgcgacu gcauguggag cggcuucucc      300

gccagcaagc cggccacccg gcgcccgccc ccgcccgucc ggugggcgaa cccccgcccc      360

cggcccgccc ccggcccccg cgcccaggcc acccggcgca ugaagaagcu gaugcuguga      420


<210>  9974
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       L-myc__Homo_sapiens__AER93388

<400>  9974
auggacuacg acuccuacca gcacuacuuc uacgacuacg acugcggcga ggacuucuac       60

cgcuccaccg cccccuccga ggacaucugg aagaaguucg agcucguccc cucccccccc      120

accucccccc ccuggggccu cggccccggc gccggcgacc ccgcccccgg caucggcccc      180

cccgagcccu ggcccggcgg cugcaccggc gacgaggccg agucccgcgg ccacuccaag      240

ggcuggggcc gcaacuacgc cuccaucauc cgccgcgacu gcaugugguc cggcuucucc      300

gccuccaagc ccgccacccg ccgccccccc ccccccgucc gcugggccaa cccccgcccc      360

cgccccgccc ccggcccccg cgcccaggcc acccgccgca ugaagaagcu caugcucuga      420


<210>  9975
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       L-myc__Homo_sapiens__AER93388

<400>  9975
auggacuacg auagcuauca gcacuacuuc uaugacuacg auugcggcga ggacuuuuau       60

agauccaccg cccccucuga agauaucugg aagaaauucg agcuggugcc uucaccaccg      120

acaagucccc cuugggggcu cggaccaggu gcuggcgacc ccgcaccugg gauuggacca      180

cccgaaccuu ggccaggcgg uuguacuggg gaugaggccg aaagcagggg acauuccaag      240

ggcuggggcc ggaacuacgc gucuauaauc cgccgagacu gcaugugguc gggguuuuca      300

gcuagcaaac cggccacgcg uagacccccu ccacccguca ggugggcaaa uccucggcca      360

cgccccgccc cgggaccuag agcucaagca accaggcgga ugaagaaacu uaugcuguga      420


<210>  9976
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       L-myc__Homo_sapiens__AER93388

<400>  9976
auggacuacg acagcuacca gcacuacuuc uacgacuacg acugcggcga ggacuucuac       60

agaagcaccg cccccagcga ggacaucugg aagaaguucg agcuggugcc cagccccccc      120

accagccccc ccuggggccu gggccccggc gccggcgacc ccgcccccgg caucggcccc      180

cccgagcccu ggcccggcgg cugcaccggc gacgaggccg agagcagagg ccacagcaag      240

ggcuggggca gaaacuacgc cagcaucauc agaagagacu gcauguggag cggcuucagc      300

gccagcaagc ccgccaccag aagacccccc ccccccguga gaugggccaa ccccagaccc      360

agacccgccc ccggccccag agcccaggcc accagaagaa ugaagaagcu gaugcuguga      420


<210>  9977
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       L-myc__Homo_sapiens__AER93388

<400>  9977
auggacuacg auagcuauca gcacuacuuc uaugacuacg auugcggcga ggacuuuuau       60

agauccaccg cccccucuga agauaucugg aagaaauucg agcuggugcc uagcccgccc      120

acauccccuc ccugggggcu cggaccuggc gcuggggacc ccgccccugg aauuggcccg      180

cccgaaccuu ggcccggggg auguacgggc gaugaggcgg aaucucgggg ccauagcaag      240

ggguggggac gcaacuacgc uuccaucauu agacgggacu gcaugugguc uggcuuuagc      300

gccuccaaac cugccacccg cagacccccg ccucccgucc ggugggcuaa uccucgcccc      360

agacccgccc cugggccgcg ggcucaagcc acacgcagaa ugaagaaacu gaugcuuuga      420


<210>  9978
<211>  420
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       L-myc__Homo_sapiens__AER93388

<400>  9978
auggauuaug auucauauca acauuauuuu uaugauuaug auuguggaga agauuuuuau       60

agaaguacag caccaaguga agauauaugg aaaaaauuug aauuaguacc aaguccacca      120

acaagcccac cauggggacu aggaccagga gcaggagauc cagcaccagg aauaggacca      180

ccagaaccau ggccaggagg auguacagga gaugaagcag aaucaagagg acauucaaaa      240

ggauggggaa gaaauuaugc aaguauaaua agaagagauu guaugugguc aggauuuagu      300

gcaaguaaac cagcaacaag aagaccacca ccaccaguaa gaugggcaaa uccaagacca      360

agaccagcac caggaccaag agcacaagca acaagaagaa ugaaaaaauu aauguuauaa      420


<210>  9979
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Nanog__Homo_sapiens__Q9H9S0

<400>  9979

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  9980
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Nanog__Homo_sapiens__AAP49529

<400>  9980
augagugugg auccagcuug uccccaaagc uugccuugcu uugaagcauc cgacuguaaa       60

gaaucuucac cuaugccugu gauuuguggg ccugaagaaa acuauccauc cuugcaaaug      120

ucuucugcug agaugccuca cacggagacu gucucuccuc uuccuuccuc cauggaucug      180

cuuauucagg acagcccuga uucuuccacc agucccaaag gcaaacaacc cacuucugca      240

gagaagagug ucgcaaaaaa ggaagacaag gucccgguca agaaacagaa gaccagaacu      300

guguucucuu ccacccagcu guguguacuc aaugauagau uucagagaca gaaauaccuc      360

agccuccagc agaugcaaga acucuccaac auccugaacc ucagcuacaa acaggugaag      420

accugguucc agaaccagag aaugaaaucu aagagguggc agaaaaacaa cuggccgaag      480

aauagcaaug gugugacgca gaaggccuca gcaccuaccu accccagccu uuacucuucc      540

uaccaccagg gaugccuggu gaacccgacu gggaaccuuc caauguggag caaccagacc      600

uggaacaauu caaccuggag caaccagacc cagaacaucc aguccuggag caaccacucc      660

uggaacacuc agaccuggug cacccaaucc uggaacaauc aggccuggaa cagucccuuc      720

uauaacugug gagaggaauc ucugcagucc ugcaugcagu uccagccaaa uucuccugcc      780

agugacuugg aggcugccuu ggaagcugcu ggggaaggcc uuaauguaau acagcagacc      840

acuagguauu uuaguacucc acaaaccaug gauuuauucc uaaacuacuc caugaacaug      900

caaccugaag acguguga                                                    918


<210>  9981
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Nanog__Homo_sapiens__AAP49529

<400>  9981
augagcgugg accccgccug cccgcagucc cugcccugcu ucgaggccag cgacugcaag       60

gaguccagcc ccaugcccgu caucugcggc ccggaggaga acuaccccuc ccuccagaug      120

agcuccgcgg agaugcccca caccgagacc gugagccccc ugccguccag cauggaccug      180

cucauccagg acucccccga cagcuccacc agccccaagg ggaagcagcc caccuccgcc      240

gagaaguccg uggccaagaa ggaggacaag gucccgguga agaagcagaa gacccgcacc      300

guguucagca gcacgcagcu gugcguccug aacgaccggu uccagcgcca gaaguaccuc      360

ucccugcagc agaugcagga gcugagcaac auccucaacc ugagcuacaa gcaggucaag      420

accugguucc agaaccagcg gaugaagucc aagcgcuggc agaagaacaa cuggcccaag      480

aacagcaacg gcgugaccca gaaggccucc gcccccaccu accccagccu guacuccagc      540

uaccaccagg ggugccucgu gaacccgacg ggcaaccugc ccaugugguc caaccagacc      600

uggaacaaca gcaccugguc caaccagacc cagaacaucc agagcugguc caaccacagc      660

uggaacacgc agaccuggug cacccagucc uggaacaacc aggcguggaa cagccccuuc      720

uacaacugcg gggaggaguc ccugcagagc ugcaugcagu uccagcccaa cuccccggcc      780

agcgaccucg aggccgcccu ggaggcggcc ggcgagggcc ugaacgugau ccagcagacc      840

acgcgguacu ucuccacgcc ccagaccaug gaccucuucc ugaacuacag caugaacaug      900

cagcccgagg acguguga                                                    918


<210>  9982
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Nanog__Homo_sapiens__AAP49529

<400>  9982
auguccgucg accccgccug cccccagucc cuccccugcu ucgaggccuc cgacugcaag       60

gaguccuccc ccaugcccgu caucugcggc cccgaggaga acuaccccuc ccuccagaug      120

uccuccgccg agaugcccca caccgagacc gucucccccc uccccuccuc cauggaccuc      180

cucauccagg acucccccga cuccuccacc ucccccaagg gcaagcagcc caccuccgcc      240

gagaaguccg ucgccaagaa ggaggacaag guccccguca agaagcagaa gacccgcacc      300

gucuucuccu ccacccagcu cugcguccuc aacgaccgcu uccagcgcca gaaguaccuc      360

ucccuccagc agaugcagga gcucuccaac auccucaacc ucuccuacaa gcaggucaag      420

accugguucc agaaccagcg caugaagucc aagcgcuggc agaagaacaa cuggcccaag      480

aacuccaacg gcgucaccca gaaggccucc gcccccaccu accccucccu cuacuccucc      540

uaccaccagg gcugccucgu caaccccacc ggcaaccucc ccaugugguc caaccagacc      600

uggaacaacu ccaccugguc caaccagacc cagaacaucc aguccugguc caaccacucc      660

uggaacaccc agaccuggug cacccagucc uggaacaacc aggccuggaa cucccccuuc      720

uacaacugcg gcgaggaguc ccuccagucc ugcaugcagu uccagcccaa cucccccgcc      780

uccgaccucg aggccgcccu cgaggccgcc ggcgagggcc ucaacgucau ccagcagacc      840

acccgcuacu ucuccacccc ccagaccaug gaccucuucc ucaacuacuc caugaacaug      900

cagcccgagg acgucuga                                                    918


<210>  9983
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Nanog__Homo_sapiens__AAP49529

<400>  9983
augagcgugg accccgccug cccucagucc cugccauguu ucgaggcuuc ugauugcaag       60

gaaucaaguc cgaugcccgu caucuguggc ccugaggaaa acuacccaag ccuccaaaug      120

uccucugcag agaugcccca caccgaaaca guuucgccuc uuccaucaag cauggaccug      180

uugauucagg auagucccga cuccucuacu agcccuaaag ggaagcagcc aacguccgcc      240

gagaaaucag uggcgaagaa agaggauaag guaccgguga agaaacagaa gaccagaaca      300

gucuuuagua gcacucaauu augcgugcug aaugacaggu uccagcggca gaaauaucua      360

ucucuccagc aaaugcagga acuguccaac auacuuaauc ugucauacaa gcagguuaaa      420

accugguuuc agaaccaacg caugaaaagc aagcgauggc agaaaaauaa cuggcccaag      480

aauaguaacg gagugacaca gaaggcuucu gccccuaccu auccauccuu guacagcucg      540

uaucaucaag guugucucgu caaucccacu ggcaaccugc cuaugugguc uaaucagaca      600

uggaacaauu ccaccugguc aaaccagacg cagaauaucc aaaguuggag caaccacucc      660

uggaacacuc agaccuggug cacacagucu uggaauaacc aggcauggaa uagcccauuc      720

uacaacugug gggaggaauc acugcaaagu ugcaugcagu uucagcccaa uuccccggcc      780

agcgaucucg aggcugcauu agaggccgcu ggagaaggcc ugaacgugau ucagcaaacu      840

acccguuauu ucucuacacc ucagaccaug gacuuguuuc uuaauuacuc aaugaacaug      900

cagcccgagg auguauga                                                    918


<210>  9984
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Nanog__Homo_sapiens__AAP49529

<400>  9984
augagcgugg accccgccug cccccagagc cugcccugcu ucgaggccag cgacugcaag       60

gagagcagcc ccaugcccgu gaucugcggc cccgaggaga acuaccccag ccugcagaug      120

agcagcgccg agaugcccca caccgagacc gugagccccc ugcccagcag cauggaccug      180

cugauccagg acagccccga cagcagcacc agccccaagg gcaagcagcc caccagcgcc      240

gagaagagcg uggccaagaa ggaggacaag gugcccguga agaagcagaa gaccagaacc      300

guguucagca gcacccagcu gugcgugcug aacgacagau uccagagaca gaaguaccug      360

agccugcagc agaugcagga gcugagcaac auccugaacc ugagcuacaa gcaggugaag      420

accugguucc agaaccagag aaugaagagc aagagauggc agaagaacaa cuggcccaag      480

aacagcaacg gcgugaccca gaaggccagc gcccccaccu accccagccu guacagcagc      540

uaccaccagg gcugccuggu gaaccccacc ggcaaccugc ccauguggag caaccagacc      600

uggaacaaca gcaccuggag caaccagacc cagaacaucc agagcuggag caaccacagc      660

uggaacaccc agaccuggug cacccagagc uggaacaacc aggccuggaa cagccccuuc      720

uacaacugcg gcgaggagag ccugcagagc ugcaugcagu uccagcccaa cagccccgcc      780

agcgaccugg aggccgcccu ggaggccgcc ggcgagggcc ugaacgugau ccagcagacc      840

accagauacu ucagcacccc ccagaccaug gaccuguucc ugaacuacag caugaacaug      900

cagcccgagg acguguga                                                    918


<210>  9985
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Nanog__Homo_sapiens__AAP49529

<400>  9985
augagcgugg accccgccug cccucagucc cugccguguu ucgaggcuuc ugauugcaag       60

gaaagcuccc ccaugccugu caucuguggc cccgaggaaa acuacccuuc ucuccaaaug      120

agcuccgccg agaugcccca caccgaaaca guuucuccuc ugccgagcuc cauggaccuu      180

cugauucagg auagccccga cucuuccacg agcccuaaag ggaagcagcc caccucugcg      240

gagaaauccg uggcuaagaa agaggauaag gugccuguca agaaacagaa gacaagaacc      300

guguuuagcu cuacacaacu cugcguucug aaugaccggu uccagcgcca gaaauaucuu      360

ucccugcagc aaaugcagga acucagcaac auccugaauc uguccuacaa acaggugaag      420

accugguuuc agaaccaaag aaugaagucu aagcgguggc agaaaaauaa cuggcccaag      480

aauagcaacg gagucacaca gaaagccucc gccccgaccu auccuagccu cuacucuucc      540

uaucaucaag gcugucuggu gaaucccacg gggaaccuuc cuauguggag caaucagacc      600

uggaacaauu cuacauggag caaccagacc cagaauauuc aauccugguc uaaccacagc      660

uggaacacac agaccuggug cacgcagucc uggaauaacc aggcuuggaa uagccccuuc      720

uacaacugug gagaggaauc ucugcaaucc ugcaugcagu uucagcccaa uagcccugcc      780

ucugaucucg aggcugcccu ggaggcggcc ggcgaagggc uuaacguuau ccagcaaaca      840

acccgcuauu ucuccacacc gcagaccaug gaccuguuuc ucaauuacag caugaacaug      900

cagcccgagg auguguga                                                    918


<210>  9986
<211>  918
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Nanog__Homo_sapiens__AAP49529

<400>  9986
augucagucg auccagcaug cccacaaucc cucccaugcu ucgaagcauc agauugcaaa       60

gaaucaucuc cuaugcccgu aauaugcgga cccgaagaaa auuacccauc acuacaaaug      120

ucaucagcag aaaugccaca cacagaaaca guaucaccuc ucccaucauc aauggaccua      180

uuaauacaag acucaccaga cucaucaaca ucaccaaaag gaaaacaacc uacaucugca      240

gaaaaaucag uagcaaaaaa agaagacaaa guaccaguaa aaaaacaaaa aacaagaaca      300

guauucuccu caacccaacu augcguacuc aaugacagau uccaaagaca aaaauaccua      360

ucacuacaac aaaugcaaga acuaucaaac auacucaacc uaucuuacaa acaaguaaaa      420

acaugguucc aaaaccaacg aaugaaauca aaaagauggc aaaaaaacaa cuggccaaaa      480

aacucuaacg gaguaacuca aaaagcauca gcaccaaccu acccaucccu auacucaucu      540

uaccaccaag gaugccuagu aaacccaaca ggaaaccuac caaugugguc aaaccaaaca      600

uggaacaauu caacaugguc aaaccaaaca caaaacauac aauccugguc caaccauuca      660

uggaacacac aaacauggug cacacaaucc uggaacaauc aagcauggaa cucaccauuc      720

uacaacugcg gagaagaauc cuuacaaucc ugcaugcaau uccaaccaaa cuccccugca      780

uccgacuuag aagcagcauu agaagcagca ggcgaaggau uaaacguaau acaacaaacu      840

acaagauacu ucucaacacc acaaacaaug gaccuauucc uaaauuacuc aaugaacaug      900

caaccagaag acgucuaa                                                    918


<210>  9987
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__P04198

<400>  9987

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 






<210>  9988
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__AAH02712

<400>  9988
augccgagcu gcuccacguc caccaugccg ggcaugaucu gcaagaaccc agaccucgag       60

uuugacucgc uacagcccug cuucuacccg gacgaagaug acuucuacuu cggcggcccc      120

gacucgaccc ccccggggga ggacaucugg aagaaguuug agcugcugcc cacgcccccg      180

cugucgccca gccguggcuu cgcggagcac agcuccgagc ccccgagcug ggucacggag      240

augcugcuug agaacgagcu guggggcagc ccggccgagg aggacgcguu cggccugggg      300

ggacugggug gccucacccc caacccgguc auccuccagg acugcaugug gagcggcuuc      360

uccgcccgcg agaagcugga gcgcgccgug agcgagaagc ugcagcacgg ccgcgggccg      420

ccaaccgccg guuccaccgc ccaguccccg ggagccggcg ccgccagccc ugcgggucgc      480

gggcacggcg gggcugcggg agccggccgc gccggggccg cccugcccgc cgagcucgcc      540

cacccggccg ccgagugcgu ggaucccgcc guggucuucc ccuuucccgu gaacaagcgc      600

gagccagcgc ccgugcccgc agccccggcc agugccccgg cggcgggccc ugcggucgcc      660

ucgggggcgg guauugccgc cccagccggg gccccggggg ucgccccucc gcgcccaggc      720

ggccgccaga ccagcggcgg cgaccacaag gcccucagua ccuccggaga ggacacccug      780

agcgauucag augaugaaga ugaugaagag gaagaugaag aggaagaaau cgacgugguc      840

acuguggaga agcggcguuc cuccuccaac accaaggcug ucaccacauu caccaucacu      900

gugcguccca agaacgcagc ccuggguccc gggagggcuc aguccagcga gcugauccuc      960

aaacgaugcc uucccaucca ccagcagcac aacuaugccg cccccucucc cuacguggag     1020

agugaggaug cacccccaca gaagaagaua aagagcgagg cguccccacg uccgcucaag     1080

agugucaucc ccccaaaggc uaagagcuug agcccccgaa acucugacuc ggaggacagu     1140

gagcgucgca gaaaccacaa cauccuggag cgccagcgcc gcaacgaccu ucgguccagc     1200

uuucucacgc ucagggacca cgugccggag uugguaaaga augagaaggc cgccaaggug     1260

gucauuuuga aaaaggccac ugaguauguc cacucccucc aggccgagga gcaccagcuu     1320

uugcuggaaa aggaaaaauu gcaggcaaga cagcagcagu ugcuaaagaa aauugaacac     1380

gcucggacuu gcuag                                                      1395


<210>  9989
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       N-myc__Homo_sapiens__AAH02712

<400>  9989
augcccagcu gcuccaccag caccaugccg ggcaugaucu gcaagaaccc cgaccuggag       60

uucgacuccc uccagcccug cuucuacccc gacgaggacg acuucuacuu cgggggcccg      120

gacagcacgc cgcccgggga ggacaucugg aagaaguucg agcugcugcc caccccgccc      180

cucuccccca gccgcggcuu cgccgagcac uccagcgagc ccccguccug ggugaccgag      240

augcugcugg agaacgagcu cugggggagc cccgccgagg aggacgcguu cggccugggc      300

gggcugggcg ggcucacccc caaccccguc auccugcagg acugcaugug guccggcuuc      360

agcgcccgcg agaagcugga gcgcgccgug uccgagaagc uccagcacgg gcggggcccg      420

cccacggccg gcagcaccgc ccaguccccc ggggcgggcg ccgccagccc cgccgggcgc      480

ggccacggcg gggcggccgg cgccgggcgg gccggcgccg cgcugccggc cgagcuggcc      540

caccccgccg ccgagugcgu ggaccccgcg gucguguucc ccuucccggu gaacaagcgc      600

gagcccgccc ccguccccgc cgccccggcc uccgcgcccg ccgccgggcc cgccguggcc      660

agcggcgcgg gcaucgccgc cccggccggg gcgcccggcg uggccccgcc ccggcccggg      720

ggccgccaga ccuccggggg cgaccacaag gcccucagca ccagcggcga ggacacgcug      780

uccgacagcg acgacgagga cgacgaggag gaggacgagg aggaggagau cgacgucgug      840

accguggaga agcggcgcuc cagcuccaac accaaggccg ucaccacguu caccaucacc      900

gugcggccca agaacgccgc gcuggggccc ggccgcgccc agagcuccga gcucauccug      960

aagcggugcc ugcccaucca ccagcagcac aacuacgccg cccccagccc cuacguggag     1020

uccgaggacg ccccgcccca gaagaagauc aagagcgagg cgagcccccg cccccucaag     1080

uccgucaucc cgcccaaggc caagucccug agcccccgga acuccgacag cgaggacucc     1140

gagcgccggc gcaaccacaa cauccuggag cggcagcgcc ggaacgaccu ccgcagcucc     1200

uuccugaccc ugcgcgacca cgugcccgag cucgugaaga acgagaaggc cgccaagguc     1260

gugauccuga agaaggccac ggaguacgug cacagccugc aggcggagga gcaccagcuc     1320

cugcuggaga aggagaagcu ccaggcccgg cagcagcagc ugcugaagaa gaucgagcac     1380

gcccggaccu gcuga                                                      1395


<210>  9990
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       N-myc__Homo_sapiens__AAH02712

<400>  9990
augcccuccu gcuccaccuc caccaugccc ggcaugaucu gcaagaaccc cgaccucgag       60

uucgacuccc uccagcccug cuucuacccc gacgaggacg acuucuacuu cggcggcccc      120

gacuccaccc cccccggcga ggacaucugg aagaaguucg agcuccuccc cacccccccc      180

cucucccccu cccgcggcuu cgccgagcac uccuccgagc cccccuccug ggucaccgag      240

augcuccucg agaacgagcu cuggggcucc cccgccgagg aggacgccuu cggccucggc      300

ggccucggcg gccucacccc caaccccguc auccuccagg acugcaugug guccggcuuc      360

uccgcccgcg agaagcucga gcgcgccguc uccgagaagc uccagcacgg ccgcggcccc      420

cccaccgccg gcuccaccgc ccaguccccc ggcgccggcg ccgccucccc cgccggccgc      480

ggccacggcg gcgccgccgg cgccggccgc gccggcgccg cccuccccgc cgagcucgcc      540

caccccgccg ccgagugcgu cgaccccgcc gucgucuucc ccuuccccgu caacaagcgc      600

gagcccgccc ccguccccgc cgcccccgcc uccgcccccg ccgccggccc cgccgucgcc      660

uccggcgccg gcaucgccgc ccccgccggc gcccccggcg ucgccccccc ccgccccggc      720

ggccgccaga ccuccggcgg cgaccacaag gcccucucca ccuccggcga ggacacccuc      780

uccgacuccg acgacgagga cgacgaggag gaggacgagg aggaggagau cgacgucguc      840

accgucgaga agcgccgcuc cuccuccaac accaaggccg ucaccaccuu caccaucacc      900

guccgcccca agaacgccgc ccucggcccc ggccgcgccc aguccuccga gcucauccuc      960

aagcgcugcc uccccaucca ccagcagcac aacuacgccg cccccucccc cuacgucgag     1020

uccgaggacg ccccccccca gaagaagauc aaguccgagg ccuccccccg cccccucaag     1080

uccgucaucc cccccaaggc caagucccuc uccccccgca acuccgacuc cgaggacucc     1140

gagcgccgcc gcaaccacaa cauccucgag cgccagcgcc gcaacgaccu ccgcuccucc     1200

uuccucaccc uccgcgacca cguccccgag cucgucaaga acgagaaggc cgccaagguc     1260

gucauccuca agaaggccac cgaguacguc cacucccucc aggccgagga gcaccagcuc     1320

cuccucgaga aggagaagcu ccaggcccgc cagcagcagc uccucaagaa gaucgagcac     1380

gcccgcaccu gcuga                                                      1395


<210>  9991
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       N-myc__Homo_sapiens__AAH02712

<400>  9991
augcccagcu gcuccaccuc uacaaugccu ggcaugaucu guaagaaccc agaccuggag       60

uucgauucac uccagccgug cuuuuacccc gacgaagaug acuucuauuu ugggggaccu      120

gauaguacuc cacccgguga ggacauuugg aaaaaguucg aacuucugcc uacgccaccc      180

uugagcccuu ccagaggcuu ugccgagcac ucuucggaac caccgucaug ggugaccgag      240

auguuacugg agaaugaacu augggggagc cccgcugagg aagaugcauu cggacucggc      300

ggucuagggg gacuuacacc uaacccaguc auacugcaag acuguaugug gaguggcuuu      360

uccgccaggg agaaauugga gcgggcgguu ucugaaaagc uccagcaugg ccgcgggccc      420

ccuacugcug gaagcaccgc ccagucccca ggugcaggcg ccgcuucacc cgcagggcga      480

ggacacggcg gugccgcugg ggccggacgu gcgggcgcag cccugccggc ugagcuggcc      540

cauccugcag cugaaugcgu ggaucccgcc guaguguucc cauuuccugu caauaaaaga      600

gagcccgcgc cagugcccgc cgccccugcu agugccccag cugccggccc ggcaguugcc      660

agcggggcug gaaucgcggc acccgccggu gcuccuggcg uggccccacc caggccuggg      720

ggacggcaga caucuggcgg ugaccacaag gcacucucca ccucagggga agauacuuua      780

agcgacagug augacgagga cgaugaggaa gaggacgaag aggaagagau ugaugucgug      840

acaguagaga agcgcagauc uuccagcaac accaaagccg uuacgacuuu caccaucaca      900

gugaggccaa agaaugcugc ccugggcccc ggacgggcac aaucgucuga acuuauuuug      960

aaacgcuguc ugccgaucca ucagcagcac aacuacgcgg cuccuucccc auaugucgag     1020

ucagaagacg cacccccuca gaagaaaaua aagagugagg caagcccccg accacuaaag     1080

uccgugaucc cucccaaagc caagucucuc agcccaagaa auucagauag ugaagacucc     1140

gagaggcggc guaaccacaa uauucuggag cgccaaagaa ggaacgaucu ucggagcucu     1200

uuucugacuu ugcgagacca ugugccggaa cucgucaaaa augagaaggc ugccaaaguu     1260

gugauccuga agaaagcaac cgaauacgua cacucauuac aggcugagga gcaucagcug     1320

cuccuugaaa aggagaagcu gcaggcccgc caacagcagu ugcugaaaaa gauugaacac     1380

gcgagaacau gcuga                                                      1395


<210>  9992
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       N-myc__Homo_sapiens__AAH02712

<400>  9992
augcccagcu gcagcaccag caccaugccc ggcaugaucu gcaagaaccc cgaccuggag       60

uucgacagcc ugcagcccug cuucuacccc gacgaggacg acuucuacuu cggcggcccc      120

gacagcaccc cccccggcga ggacaucugg aagaaguucg agcugcugcc cacccccccc      180

cugagcccca gcagaggcuu cgccgagcac agcagcgagc cccccagcug ggugaccgag      240

augcugcugg agaacgagcu guggggcagc cccgccgagg aggacgccuu cggccugggc      300

ggccugggcg gccugacccc caaccccgug auccugcagg acugcaugug gagcggcuuc      360

agcgccagag agaagcugga gagagccgug agcgagaagc ugcagcacgg cagaggcccc      420

cccaccgccg gcagcaccgc ccagagcccc ggcgccggcg ccgccagccc cgccggcaga      480

ggccacggcg gcgccgccgg cgccggcaga gccggcgccg cccugcccgc cgagcuggcc      540

caccccgccg ccgagugcgu ggaccccgcc gugguguucc ccuuccccgu gaacaagaga      600

gagcccgccc ccgugcccgc cgcccccgcc agcgcccccg ccgccggccc cgccguggcc      660

agcggcgccg gcaucgccgc ccccgccggc gcccccggcg uggccccccc cagacccggc      720

ggcagacaga ccagcggcgg cgaccacaag gcccugagca ccagcggcga ggacacccug      780

agcgacagcg acgacgagga cgacgaggag gaggacgagg aggaggagau cgacguggug      840

accguggaga agagaagaag cagcagcaac accaaggccg ugaccaccuu caccaucacc      900

gugagaccca agaacgccgc ccugggcccc ggcagagccc agagcagcga gcugauccug      960

aagagaugcc ugcccaucca ccagcagcac aacuacgccg cccccagccc cuacguggag     1020

agcgaggacg ccccccccca gaagaagauc aagagcgagg ccagccccag accccugaag     1080

agcgugaucc cccccaaggc caagagccug agccccagaa acagcgacag cgaggacagc     1140

gagagaagaa gaaaccacaa cauccuggag agacagagaa gaaacgaccu gagaagcagc     1200

uuccugaccc ugagagacca cgugcccgag cuggugaaga acgagaaggc cgccaaggug     1260

gugauccuga agaaggccac cgaguacgug cacagccugc aggccgagga gcaccagcug     1320

cugcuggaga aggagaagcu gcaggccaga cagcagcagc ugcugaagaa gaucgagcac     1380

gccagaaccu gcuga                                                      1395


<210>  9993
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       N-myc__Homo_sapiens__AAH02712

<400>  9993
augcccagcu gcuccaccuc uacaaugccu ggcaugaucu guaagaaccc ggaccuggag       60

uucgauagcc uccagcccug cuuuuacccu gacgaagaug acuucuauuu ugggggaccc      120

gauuccacgc cucccggcga ggacauuugg aaaaaguucg aacugcuucc uaccccgccc      180

cugucuccua gcagaggguu ugccgagcac uccucugaac ccccuagcug ggugacagag      240

augcuccugg agaaugaacu uuggggaucc cccgcugagg aagaugccuu cggccucggg      300

ggacugggcg gccugacccc gaacccuguc auccugcaag acuguaugug gagcggguuu      360

ucugcgcggg agaaacucga gcgcgcuguu uccgaaaagc ugcagcaugg aagaggaccc      420

ccuacagccg ggagcaccgc ccagucuccc ggagcuggcg ccgcuucccc cgccgggcgg      480

ggacacggcg gcgcggccgg ggcuggacgc gccggcgcug cccuuccugc ggagcuggcc      540

cauccggcug ccgaaugcgu ggaucccgcu guggucuucc cuuuucccgu gaauaaaaga      600

gagccugccc ccguuccggc cgcuccugcg agcgcccccg cugccgggcc ugccguggcu      660

ucuggagccg gcauugcggc ucccgccggg gccccuggag ucgcuccccc gcggccuggc      720

ggccgccaga cauccggggg agaccacaag gcccucagca ccuccggcga agauacgcug      780

ucugacagcg augacgagga cgaugaggaa gaggacgaag aggaagagau cgaugugguu      840

accguggaga agagacgguc cagcucuaac acaaaagcug ucaccacauu caccauuacg      900

gugcgcccca agaaugccgc gcuugggccc ggcagagccc aauccagcga acugauccuc      960

aaacgguguc ugccuaucca ucagcagcac aacuacgcug ccccgucucc cuauguggag     1020

agcgaagacg cuccucccca gaagaaaauu aaguccgagg ccucuccucg cccccucaag     1080

agcgucaucc cucccaaagc gaagucccug agcccgagaa auucugauuc cgaagacagc     1140

gagcggcgca gaaaccacaa uauucuggag cggcaaagac gcaacgaucu ucggucuucc     1200

uuucugacac ucagagacca uguuccugaa cuggugaaaa augagaaggc cgcuaaagug     1260

gucauccuua agaaagccac cgaauacgug cacagccugc aggcugagga gcaucagcuc     1320

cugcuggaaa aggagaagcu ccaggcccgc caacagcagc ugcuuaaaaa gauugaacac     1380

gcccggacau gcuga                                                      1395


<210>  9994
<211>  1395
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       N-myc__Homo_sapiens__AAH02712

<400>  9994
augccaucau guucaacaag cacaaugcca ggaaugauau gcaaaaaucc ugaucuagaa       60

uucgacaguu uacaaccaug uuucuaucca gaugaagaug auuuuuacuu cggcggacca      120

gacucaacac caccaggaga agauauaugg aaaaaauuug aauuacuacc caccccccca      180

uuaucaccga guagaggauu cgcagaacau ucaucagaac caccaaguug gguaacagaa      240

auguuacucg aaaacgaauu auggggaagu ccugcggaag aagaugcuuu uggacuaggc      300

ggacuaggag gauuaacacc aaauccaguu auauuacaag acuguaugug gucaggauuc      360

uccgcacgcg aaaaauuaga aagagcagua ucagaaaaac uacaacaugg cagaggacca      420

ccaacagcag guucaacagc ucaaucuccc ggagcaggcg cagcaagucc agcaggaaga      480

ggacauggag gagccgcagg agcaggacgc gccggagcug cacuaccagc agaauuagcu      540

cauccagcag cagaaugugu agacccagca guaguuuuuc cuuuuccugu aaauaaaaga      600

gaaccagccc caguaccagc agcuccagcc ucagcaccag cagcaggucc cgccguagca      660

ucaggagcag gaauagcagc accagcagga gcaccuggag uggcaccucc acgaccaggu      720

ggacgacaaa caagcggugg agaucacaaa gcacuuucaa ccucaggaga agauacauua      780

agugauagug augaugaaga cgaugaagaa gaagacgaag aagaagaaau agacguaguc      840

acugucgaaa aaagacgauc aucaucaaac acaaaagcug uaacaacuuu uacgauuaca      900

guaagaccaa aaaacgccgc acuaggucca ggaagagcac aaucaucuga auuaauacua      960

aaaagauguc uaccaauuca ucaacaacac aauuaugcag caccaucacc auauguugaa     1020

agcgaagaug caccaccaca aaaaaagauu aaaucugaag caucaccaag accauuaaaa     1080

aguguaauac caccaaaagc aaaaucguua uccccucgaa acucagauuc agaagauuca     1140

gaacgaagaa gaaaucauaa cauucuagaa agacaacgaa gaaaugauuu aagaaguuca     1200

uuccuuacac uaagagauca uguuccagaa cuaguaaaaa augaaaaagc agcaaaaguu     1260

guaauucuaa aaaaagcaac agaauaugua cauuccuuac aagcugaaga acaucaauua     1320

uuacuugaaa aagaaaaauu acaagcaaga caacaacaac uacuaaaaaa aauagaacac     1380

gcacgcacau gcuaa                                                      1395


<210>  9995
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__Q9H224

<400>  9995

Met Arg Gly Ala Pro Gly Asn Cys Val Gly Ala Glu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Arg Lys Arg Ala Gln Thr Val Ala Ile Arg Gly His Pro Arg Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Asp Thr Arg Ala Glu Ser Pro Pro Asp Pro Leu 
        35                  40                  45              


Gln Ser Ala Gly Val Leu Glu Val Gly Ala Gly Pro Arg Leu Pro Arg 
    50                  55                  60                  


Pro Pro Arg Glu Gly Ser Thr Pro Gly Ile Lys Thr Asn Gly Ala Glu 
65                  70                  75                  80  


Arg Ser Pro Gln Ser Pro Ala Gly Arg Arg Ala Asp Ala Glu Leu Leu 
                85                  90                  95      


His Val His His Ala Gly His Asp Leu Gln Glu Pro Arg Pro Arg Val 
            100                 105                 110         






<210>  9996
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__AAG40001

<400>  9996
augcgggggg cuccugggaa cuguguugga gccgagcaag cgcuagccag gcgcaagcgc       60

gcacagacug uagccauccg aggacacccc cgcccccccg gcccacccgg agacacccgc      120

gcagaaucgc cuccggaucc ccugcagucg gcgggagugu uggaggucgg cgccggcccc      180

cgccuuccgc gccccccacg ggaaggaagc acccccggua uuaaaacgaa cggggcggaa      240

agaagcccuc agucgccggc cgggaggcga gccgaugccg agcugcucca cguccaccau      300

gccgggcaug aucugcaaga acccagaccu cgaguuuga                             339


<210>  9997
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       N-myc__Homo_sapiens__AAG40001

<400>  9997
augcgcggcg cccccgggaa cugcgugggc gccgagcagg cgcuggcccg gcgcaagcgg       60

gcccagaccg ucgccauccg cgggcacccg cggccgcccg gcccgcccgg ggacacccgc      120

gccgagagcc cgcccgaccc ccuccagucc gcgggcgugc uggagguggg cgccgggccc      180

cggcugcccc gcccgccccg ggagggcagc acgcccggga ucaagaccaa cggcgccgag      240

cgcagccccc agucccccgc cgggcggcgc gcggacgccg agcuccugca cguccaccac      300

gccggccacg accugcagga gccccggccc cgcguguga                             339


<210>  9998
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       N-myc__Homo_sapiens__AAG40001

<400>  9998
augcgcggcg cccccggcaa cugcgucggc gccgagcagg cccucgcccg ccgcaagcgc       60

gcccagaccg ucgccauccg cggccacccc cgcccccccg gcccccccgg cgacacccgc      120

gccgaguccc cccccgaccc ccuccagucc gccggcgucc ucgaggucgg cgccggcccc      180

cgccuccccc gccccccccg cgagggcucc acccccggca ucaagaccaa cggcgccgag      240

cgcucccccc agucccccgc cggccgccgc gccgacgccg agcuccucca cguccaccac      300

gccggccacg accuccagga gccccgcccc cgcgucuga                             339


<210>  9999
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       N-myc__Homo_sapiens__AAG40001

<400>  9999
augagaggcg cccccgggaa cugcguggga gcugagcagg cacuggccag gcggaagcgc       60

gcgcaaaccg ucgcuauccg aggucacccu cguccaccgg ggcccccugg cgacacaaga      120

gccgaaagcc cacccgaucc ucuccagucc gcaggaguuc uugagguggg cgccggucca      180

aggcugcccc ggccuccacg cgaagggucu acuccgggaa uuaaaacgaa uggcgcugag      240

agaucacccc agaguccugc aggcaggcgg gccgacgcug aauuguuaca uguacaccau      300

gccgggcacg aucugcagga gccacgcccc cgaguguga                             339


<210>  10000
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       N-myc__Homo_sapiens__AAG40001

<400>  10000
augagaggcg cccccggcaa cugcgugggc gccgagcagg cccuggccag aagaaagaga       60

gcccagaccg uggccaucag aggccacccc agaccccccg gcccccccgg cgacaccaga      120

gccgagagcc cccccgaccc ccugcagagc gccggcgugc uggagguggg cgccggcccc      180

agacugccca gaccccccag agagggcagc acccccggca ucaagaccaa cggcgccgag      240

agaagccccc agagccccgc cggcagaaga gccgacgccg agcugcugca cgugcaccac      300

gccggccacg accugcagga gcccagaccc agaguguga                             339


<210>  10001
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       N-myc__Homo_sapiens__AAG40001

<400>  10001
augagaggcg cccccgggaa cugcguggga gcugagcagg cccuggcgcg gcgcaagaga       60

gcucaaaccg ucgccauccg gggccacccu cgcccgcccg ggccucccgg agacacaaga      120

gccgaaagcc cucccgaucc ucuccagucc gcuggcguuc uggagguggg ggccggaccg      180

cggcuucccc gcccucccag agaaggcucu acgccuggca uuaaaaccaa uggggcugag      240

cggagccccc aguccccggc cggacgcaga gcggacgccg aacugcucca ugugcaccau      300

gcuggccacg aucugcagga gccucggccc cgcgucuga                             339


<210>  10002
<211>  339
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       N-myc__Homo_sapiens__AAG40001

<400>  10002
augagaggag caccaggaaa cuguguagga gcagaacaag cauuagcaag aagaaaaaga       60

gcacaaacag uagcaauaag aggacaccca agaccaccag gaccaccagg agauacaaga      120

gcagaaucac cuccagaucc auuacaauca gcaggaguau uagaaguagg agcaggacca      180

agauuaccaa gaccaccaag agaaggauca acaccaggaa uaaaaacaaa cggagcagaa      240

agaucaccac aaucaccagc aggaagaaga gcagaugcag aacuauuaca cguacaccau      300

gcaggacacg auuuacaaga accaagacca agaguauaa                             339


<210>  10003
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__V9H1L1

<400>  10003

Met Arg Gly Ala Pro Gly Asn Cys Val Gly Ala Glu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Arg Lys Arg Ala Gln Thr Val Ala Ile Arg Gly His Pro Arg Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Asp Thr Arg Ala Glu Ser Pro Pro Asp Pro Leu 
        35                  40                  45              


Gln Ser Ala Gly Gly Lys Glu Gln Gly Leu Gln Thr Ala Arg Arg Pro 
    50                  55                  60                  


Gly Lys Arg Arg Ala Pro Gly Gln Gly Lys Pro Trp Thr Gly Leu Arg 
65                  70                  75                  80  


Arg Ala His Arg Ala Pro 
                85      


<210>  10004
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  N-myc__Homo_sapiens__CAA68677

<400>  10004
augcgggggg cuccugggaa cuguguugga gccgagcaag cgcuagccag gcgcaagcgc       60

gcacagacug uagccauccg aggacacccc cgcccccccg gcccacccgg agacacccgc      120

gcagaaucgc cuccggaucc ccugcagucg gcgggaggua aggagcaggg cuugcaaacc      180

gcccggcgcc cagggaagcg acgagcgccg gggcaaggca agcccuggac gggauugcga      240

cgugcgcacc gggcgcccua a                                                261


<210>  10005
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       N-myc__Homo_sapiens__CAA68677

<400>  10005
augcgcggcg cccccgggaa cugcgugggc gccgagcagg cgcuggcccg gcgcaagcgg       60

gcccagaccg ucgccauccg cgggcacccc cggccgcccg gcccgcccgg ggacacccgc      120

gccgagagcc cgcccgaccc ccuccagucc gcgggcggca aggagcaggg gcugcagacg      180

gcccggcgcc ccggcaagcg gcgcgccccc gggcagggca agcccuggac cgggcugcgg      240

cgcgcccacc gggcgcccug a                                                261


<210>  10006
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       N-myc__Homo_sapiens__CAA68677

<400>  10006
augcgcggcg cccccggcaa cugcgucggc gccgagcagg cccucgcccg ccgcaagcgc       60

gcccagaccg ucgccauccg cggccacccc cgcccccccg gcccccccgg cgacacccgc      120

gccgaguccc cccccgaccc ccuccagucc gccggcggca aggagcaggg ccuccagacc      180

gcccgccgcc ccggcaagcg ccgcgccccc ggccagggca agcccuggac cggccuccgc      240

cgcgcccacc gcgcccccug a                                                261


<210>  10007
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       N-myc__Homo_sapiens__CAA68677

<400>  10007
augagaggcg cccccgggaa cugcguggga gcugagcagg cacuggccag gcggaagcgc       60

gcgcaaaccg ucgcuauccg aggucacccu cguccaccgg ggcccccugg cgacacaaga      120

gccgaaagcc cacccgaucc ucuccagucc gcaggaggca aagagcaggg ucuucagacu      180

gccaggcggc cagggaagcg cagagcuccc ggacaaggca aaccuuggac gggccugagg      240

cgggcacauc gcgccccaug a                                                261


<210>  10008
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       N-myc__Homo_sapiens__CAA68677

<400>  10008
augagaggcg cccccggcaa cugcgugggc gccgagcagg cccuggccag aagaaagaga       60

gcccagaccg uggccaucag aggccacccc agaccccccg gcccccccgg cgacaccaga      120

gccgagagcc cccccgaccc ccugcagagc gccggcggca aggagcaggg ccugcagacc      180

gccagaagac ccggcaagag aagagccccc ggccagggca agcccuggac cggccugaga      240

agagcccaca gagcccccug a                                                261


<210>  10009
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       N-myc__Homo_sapiens__CAA68677

<400>  10009
augagaggcg cccccgggaa cugcguggga gcugagcagg cccuggcgcg gcgcaagaga       60

gcucaaaccg ucgccauccg gggccacccu cgcccgcccg ggccucccgg agacacaaga      120

gccgaaagcc cucccgaucc ucuccagucc gcuggcggga aagagcaggg acugcagacg      180

gcccggcgcc cgggcaagag acgggcuccc ggccaaggga aaccuuggac cggacuucgc      240

agagcccauc gggcgcccug a                                                261


<210>  10010
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       N-myc__Homo_sapiens__CAA68677

<400>  10010
augagaggag caccaggaaa uugcguagga gcagaacaag cauuagcaag aagaaaaaga       60

gcacaaacag uagcaauaag aggacaucca agaccaccag gaccaccagg agacacaaga      120

gcagaaucac caccagaccc acuacaaagu gcaggaggaa aagaacaagg acuacaaaca      180

gcaagaagac caggaaaaag aagagcacca ggacaaggaa aaccauggac aggauuaaga      240

agagcacaua gagcaccaua a                                                261


<210>  10011
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Oct3__Homo_sapiens__Q01860

<400>  10011

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  10012
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Oct3__Homo_sapiens__AAI17436

<400>  10012
auggcgggac accuggcuuc ggauuucgcc uucucgcccc cuccaggugg uggaggugau       60

gggccagggg ggccggagcc gggcuggguu gauccucgga ccuggcuaag cuuccaaggc      120

ccuccuggag ggccaggaau cgggccgggg guugggccag gcucugaggu gugggggauu      180

cccccaugcc ccccgccgua ugaguucugu ggggggaugg cguacugugg gccccagguu      240

ggaguggggc uagugcccca aggcggcuug gagaccucuc agccugaggg cgaagcagga      300

gucggggugg agagcaacuc cgauggggcc uccccggagc ccugcaccgu caccccuggu      360

gccgugaagc uggagaagga gaagcuggag caaaacccgg aggaguccca ggacaucaaa      420

gcucugcaga aagaacucga gcaauuugcc aagcuccuga agcagaagag gaucacccug      480

ggauauacac aggccgaugu ggggcucacc cuggggguuc uauuugggaa gguauucagc      540

caaacgacca ucugccgcuu ugaggcucug cagcuuagcu ucaagaacau guguaagcug      600

cggcccuugc ugcagaagug gguggaggaa gcugacaaca augaaaaucu ucaggagaua      660

ugcaaagcag aaacccucgu gcaggcccga aagagaaagc gaaccaguau cgagaaccga      720

gugagaggca accuggagaa uuuguuccug cagugcccga aacccacacu gcagcagauc      780

agccacaucg cccagcagcu ugggcucgag aaggaugugg uccgagugug guucuguaac      840

cggcgccaga agggcaagcg aucaagcagc gacuaugcac aacgagagga uuuugaggcu      900

gcugggucuc cuuucucagg gggaccagug uccuuuccuc uggccccagg gccccauuuu      960

gguaccccag gcuaugggag cccucacuuc acugcacugu acuccucggu cccuuucccu     1020

gagggggaag ccuuuccccc ugucuccguc accacucugg gcucucccau gcauucaaac     1080

uga                                                                   1083


<210>  10013
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Oct3__Homo_sapiens__AAI17436

<400>  10013
auggccggcc accuggccag cgacuucgcg uucuccccgc cgcccggggg cgggggcgac       60

gggcccggcg gccccgagcc ggggugggug gacccccgca ccuggcucag cuuccagggc      120

ccgcccgggg gccccgggau cggccccggc gucgggcccg gcuccgaggu gugggggauc      180

ccgcccugcc cgccgcccua cgaguucugc ggcggcaugg ccuacugcgg gccccaggug      240

ggcgucgggc uggugcccca gggcgggcug gagaccagcc agcccgaggg cgaggccggc      300

gugggggucg aguccaacag cgacggcgcc ucccccgagc ccugcacggu gacccccggg      360

gccgugaagc ucgagaagga gaagcuggag cagaaccccg aggagagcca ggacaucaag      420

gcgcugcaga aggagcucga gcaguucgcc aagcugcuga agcagaagcg gaucacccuc      480

ggcuacaccc aggccgacgu cgggcugacg cugggcgucc ucuucggcaa gguguucucc      540

cagaccacca ucugccgcuu cgaggcccug cagcugagcu ucaagaacau gugcaagcuc      600

cggccccugc ugcagaagug gguggaggag gcggacaaca acgagaaccu ccaggagauc      660

ugcaaggccg agacccuggu gcaggcccgc aagcggaagc gcacguccau cgagaaccgg      720

gugcgcggga accuggagaa ccucuuccug cagugcccca agcccacccu gcagcagauc      780

agccacaucg cccagcagcu cggccuggag aaggacgucg ugcgggugug guucugcaac      840

cgccggcaga aggggaagcg cuccagcucc gacuacgccc agcgggagga cuucgaggcg      900

gccggcagcc ccuucuccgg gggccccguc agcuucccgc uggcccccgg cccccacuuc      960

gggaccccgg gcuacgggag cccccacuuc accgcccucu acuccagcgu gcccuucccc     1020

gagggcgagg ccuucccgcc cguguccguc acgacccugg gcagccccau gcacuccaac     1080

uga                                                                   1083


<210>  10014
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Oct3__Homo_sapiens__AAI17436

<400>  10014
auggccggcc accucgccuc cgacuucgcc uucucccccc cccccggcgg cggcggcgac       60

ggccccggcg gccccgagcc cggcuggguc gacccccgca ccuggcucuc cuuccagggc      120

ccccccggcg gccccggcau cggccccggc gucggccccg gcuccgaggu cuggggcauc      180

ccccccugcc ccccccccua cgaguucugc ggcggcaugg ccuacugcgg cccccagguc      240

ggcgucggcc ucguccccca gggcggccuc gagaccuccc agcccgaggg cgaggccggc      300

gucggcgucg aguccaacuc cgacggcgcc ucccccgagc ccugcaccgu cacccccggc      360

gccgucaagc ucgagaagga gaagcucgag cagaaccccg aggaguccca ggacaucaag      420

gcccuccaga aggagcucga gcaguucgcc aagcuccuca agcagaagcg caucacccuc      480

ggcuacaccc aggccgacgu cggccucacc cucggcgucc ucuucggcaa ggucuucucc      540

cagaccacca ucugccgcuu cgaggcccuc cagcucuccu ucaagaacau gugcaagcuc      600

cgcccccucc uccagaagug ggucgaggag gccgacaaca acgagaaccu ccaggagauc      660

ugcaaggccg agacccucgu ccaggcccgc aagcgcaagc gcaccuccau cgagaaccgc      720

guccgcggca accucgagaa ccucuuccuc cagugcccca agcccacccu ccagcagauc      780

ucccacaucg cccagcagcu cggccucgag aaggacgucg uccgcgucug guucugcaac      840

cgccgccaga agggcaagcg cuccuccucc gacuacgccc agcgcgagga cuucgaggcc      900

gccggcuccc ccuucuccgg cggccccguc uccuuccccc ucgcccccgg cccccacuuc      960

ggcacccccg gcuacggcuc cccccacuuc accgcccucu acuccuccgu ccccuucccc     1020

gagggcgagg ccuucccccc cgucuccguc accacccucg gcucccccau gcacuccaac     1080

uga                                                                   1083


<210>  10015
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Oct3__Homo_sapiens__AAI17436

<400>  10015
auggccggcc accuggcuag cgacuucgca uuuagucccc cuccaggggg agguggcgau       60

gggccgggag gccccgaacc ugguugggug gacccaagaa ccuggcucuc uuuccagggg      120

cccccuggag gcccaggcau cgggcccgga gucgguccug gcucagaagu uugggggauu      180

ccaccguguc ccccuccaua cgaguuuugc ggaggcaugg ccuauugcgg uccccaagug      240

gggguaggac uugugccuca gggcggccug gaaacaaguc agccagaggg ggaagcggga      300

gucggugugg agagcaacuc cgauggcgcu ucucccgagc cguguacugu uacgccuggg      360

gccgugaagu uggaaaaaga gaaguuagaa cagaaucccg aggagucgca agacauaaaa      420

gcacugcaga aggaacuaga gcaguucgcc aaacuccuga agcagaagag gaucacccuu      480

ggauacacac aagcugaugu cggccugacu uugggugugc ucuuugggaa aguauucuca      540

cagaccacaa uuugccgguu ugaagcacug cagcugagcu ucaagaacau guguaaacuc      600

cgcccauuac ugcagaagug gguugaggaa gccgacaaua acgagaaucu ucaagagauc      660

ugcaaagcug aaaccuuggu gcaggcccga aagcguaaga gaacuuccau ugagaacagg      720

guccggggca aucuggaaaa ccuauuucuc caguguccua aacccacacu gcaacagauc      780

ucccauauag cgcagcagcu uggacuggag aaggaugugg ugcgcgucug guucugcaau      840

agaaggcaaa aaggcaagcg gucuagcucc gacuaugcac agcgcgaaga uuuugaggcc      900

gcugggucac cauucagugg aggucccguu agcuuuccuu uggccccagg cccgcacuuc      960

gggacccccg gauacggcuc uccucauuuc acggcacucu auuccucagu gccauuuccc     1020

gagggugagg cuuucccucc aguaagcgug acuacccugg ggagucccau gcacucuaac     1080

uga                                                                   1083


<210>  10016
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Oct3__Homo_sapiens__AAI17436

<400>  10016
auggccggcc accuggccag cgacuucgcc uucagccccc cccccggcgg cggcggcgac       60

ggccccggcg gccccgagcc cggcugggug gaccccagaa ccuggcugag cuuccagggc      120

ccccccggcg gccccggcau cggccccggc gugggccccg gcagcgaggu guggggcauc      180

ccccccugcc ccccccccua cgaguucugc ggcggcaugg ccuacugcgg cccccaggug      240

ggcgugggcc uggugcccca gggcggccug gagaccagcc agcccgaggg cgaggccggc      300

gugggcgugg agagcaacag cgacggcgcc agccccgagc ccugcaccgu gacccccggc      360

gccgugaagc uggagaagga gaagcuggag cagaaccccg aggagagcca ggacaucaag      420

gcccugcaga aggagcugga gcaguucgcc aagcugcuga agcagaagag aaucacccug      480

ggcuacaccc aggccgacgu gggccugacc cugggcgugc uguucggcaa gguguucagc      540

cagaccacca ucugcagauu cgaggcccug cagcugagcu ucaagaacau gugcaagcug      600

agaccccugc ugcagaagug gguggaggag gccgacaaca acgagaaccu gcaggagauc      660

ugcaaggccg agacccuggu gcaggccaga aagagaaaga gaaccagcau cgagaacaga      720

gugagaggca accuggagaa ccuguuccug cagugcccca agcccacccu gcagcagauc      780

agccacaucg cccagcagcu gggccuggag aaggacgugg ugagagugug guucugcaac      840

agaagacaga agggcaagag aagcagcagc gacuacgccc agagagagga cuucgaggcc      900

gccggcagcc ccuucagcgg cggccccgug agcuuccccc uggcccccgg cccccacuuc      960

ggcacccccg gcuacggcag cccccacuuc accgcccugu acagcagcgu gcccuucccc     1020

gagggcgagg ccuucccccc cgugagcgug accacccugg gcagccccau gcacagcaac     1080

uga                                                                   1083


<210>  10017
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Oct3__Homo_sapiens__AAI17436

<400>  10017
auggccggcc accuggcuag cgacuucgcc uuuuccccgc cucccggggg aggcggggau       60

ggacccggcg ggccugagcc cggaugggug gacccuagaa ccuggcucuc uuuccagggg      120

cccccuggcg gcccgggaau cggccccggg gucggaccug gcagcgaagu uugggggauu      180

cccccuuguc ccccgccuua cgaguuuugc ggaggcaugg cguauugcgg cccccaagug      240

ggggugggac uggucccuca gggcgggcuu gaaacauccc agcccgaggg agaagcuggc      300

guggggguug agucuaacag cgauggagcc ucccccgagc cuuguacggu gaccccgggc      360

gccgucaagc uggaaaaaga gaagcucgaa cagaaucccg aggagucuca agacaucaaa      420

gcucugcaga aggaacuuga gcaguucgcc aaacugcuca agcagaagcg gauuacacug      480

ggcuacaccc aagcugaugu ggggcugaca cucggaguuc uguuuggcaa aguguucagc      540

cagaccacaa ucugccgcuu ugaagcccuu cagcuguccu ucaagaacau guguaaacuc      600

agaccucugc uucagaagug ggucgaggaa gcggacaaua acgagaaucu gcaagagauu      660

ugcaaagccg aaacccucgu gcaggcucgg aagcgcaaga gaacgagcau cgagaaccgg      720

gugcgcggga aucuggaaaa ccuguuucuc caguguccca aaccuacccu gcaacagauc      780

ucucauauug cccagcagcu uggacuggag aaggaugucg uuagagugug guucugcaau      840

cggcgccaaa aaggcaagag auccagcucu gacuaugcuc agcgggaaga uuuugaggcc      900

gcgggguccc ccuucagcgg cggaccggug ucuuuuccuc ucgcccccgg cccucacuuc      960

gggacacccg gauacggcuc cccucauuuc accgcucugu auagcuccgu ccccuuuccg     1020

gagggggaag ccuucccucc cgugucuguu acaacccuug gaagccccau gcacuccaac     1080

uga                                                                   1083


<210>  10018
<211>  1083
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Oct3__Homo_sapiens__AAI17436

<400>  10018
auggcaggac aucuagcauc agauuuugca uuuagcccac caccaggagg uggaggagac       60

gguccaggag gaccagaacc aggaugggua gauccaagaa caugguuauc guuucaagga      120

ccaccaggcg gaccuggaau aggaccagga guaggcccag gaucagaagu auggggaaua      180

ccuccaugcc caccaccaua ugaauucugu ggaggaaugg cauacugugg accacaagua      240

ggaguagguu uaguaccaca agguggauua gaaaccucac aaccagaagg ugaagcagga      300

guaggaguag aaucaaauuc agauggagca ucaccagaac cuuguacagu uacaccagga      360

gcaguuaaac uugaaaaaga aaaauuagaa caaaacccag aagaaucaca agauauaaaa      420

gcauuacaaa aagaauuaga acaauucgca aaauuauuga aacaaaaaag aauaacacuc      480

ggauacacac aagcagaugu aggauuaacu uuaggaguac uauuuggaaa aguauuuagu      540

caaacaacaa uauguagauu cgaagcauua caauuauccu uuaaaaauau gugcaaacua      600

agaccacuac uacaaaaaug gguagaagaa gcagauaaua augaaaaccu ucaagaaaua      660

uguaaagcag aaacacuagu acaagcaaga aaaagaaaaa gaacaucaau agaaaauaga      720

guaagaggua aucuagaaaa uuuauuucuu caauguccca aaccaacacu acaacaaaua      780

ucacacauag cacaacaauu aggauuagaa aaagauguag uaagaguaug guuuuguaau      840

cgaagacaaa aaggaaaaag aucaucauca gauuaugcac aaagggaaga uuucgaagca      900

gcaggaaguc cauuuagugg aggaccaguc ucauuuccau uagcacccgg uccacauuuu      960

ggaacaccag gauauggauc accacauuuu acagcuuuau auucaagugu accauuuccu     1020

gaaggugaag cuuucccacc aguaucaguu acaacauuag gaucaccaau gcauucaaac     1080

uaa                                                                   1083


<210>  10019
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Sox15__Homo_sapiens__O60248

<400>  10019

Met Ala Leu Pro Gly Ser Ser Gln Asp Gln Ala Trp Ser Leu Glu Pro 
1               5                   10                  15      


Pro Ala Ala Thr Ala Ala Ala Ser Ser Ser Ser Gly Pro Gln Glu Arg 
            20                  25                  30          


Glu Gly Ala Gly Ser Pro Ala Ala Pro Gly Thr Leu Pro Leu Glu Lys 
        35                  40                  45              


Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Ser Ala Gln Arg 
    50                  55                  60                  


Arg Gln Met Ala Gln Gln Asn Pro Lys Met His Asn Ser Glu Ile Ser 
65                  70                  75                  80  


Lys Arg Leu Gly Ala Gln Trp Lys Leu Leu Asp Glu Asp Glu Lys Arg 
                85                  90                  95      


Pro Phe Val Glu Glu Ala Lys Arg Leu Arg Ala Arg His Leu Arg Asp 
            100                 105                 110         


Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Ala Lys Ser Ser Gly 
        115                 120                 125             


Ala Gly Pro Ser Arg Cys Gly Gln Gly Arg Gly Asn Leu Ala Ser Gly 
    130                 135                 140                 


Gly Pro Leu Trp Gly Pro Gly Tyr Ala Thr Thr Gln Pro Ser Arg Gly 
145                 150                 155                 160 


Phe Gly Tyr Arg Pro Pro Ser Tyr Ser Thr Ala Tyr Leu Pro Gly Ser 
                165                 170                 175     


Tyr Gly Ser Ser His Cys Lys Leu Glu Ala Pro Ser Pro Cys Ser Leu 
            180                 185                 190         


Pro Gln Ser Asp Pro Arg Leu Gln Gly Glu Leu Leu Pro Thr Tyr Thr 
        195                 200                 205             


His Tyr Leu Pro Pro Gly Ser Pro Thr Pro Tyr Asn Pro Pro Leu Ala 
    210                 215                 220                 


Gly Ala Pro Met Pro Leu Thr His Leu 
225                 230             


<210>  10020
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Sox15__Homo_sapiens__AAH00985

<400>  10020
auggcgcuac caggcuccuc acaggaccag gccuggagcc uggagccucc ggcugccacg       60

gcugcugccu ccucaucuuc gggaccccag gagcgggagg gcgcugggag ccccgcggcc      120

cccgggacgc ugccccugga gaaggugaag cggccgauga acgcguucau gguguggagc      180

uccgcucagc gccgccagau ggcgcagcag aaccccaaga ugcacaacuc cgagaucucc      240

aagcgccugg gcgcgcagug gaagcugcug gacgaggacg agaagcggcc cuucguggag      300

gaggccaagc ggcuccgcgc ccgacaccug cgcgacuacc ccgacuacaa guaccggccu      360

cggcgcaagg ccaagagcuc gggcgccgga ccuucccgcu gcggacaggg aagaggcaac      420

cuggccagcg gcggcccgcu cugggggccg ggguacgcga ccacccaacc gagcagaggc      480

uuuggguaca gaccccccag cuacucgaca gccuaccugc cuggcagcua uggcucuucc      540

cacugcaaac uggaagcccc cucaccgugc ucccucccuc agagugaccc uaggcuccag      600

ggggaacugc ugcccaccua uacccacuac cugcccccug gcucucccac uccauacaac      660

ccuccccuug cuggugcccc caugccccua acccaccucu aa                         702


<210>  10021
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Sox15__Homo_sapiens__AAH00985

<400>  10021
auggcccugc ccggcagcuc ccaggaccag gccuggagcc ucgagccgcc cgcggccacc       60

gccgccgccu ccagcuccag cgggccccag gagcgcgagg gcgcgggguc ccccgccgcc      120

ccgggcaccc ugccccugga gaaggugaag cggcccauga acgccuucau ggucuggagc      180

uccgcgcagc gccggcagau ggcccagcag aaccccaaga ugcacaacag cgagaucucc      240

aagcgccucg gggcccagug gaagcugcug gacgaggacg agaagcggcc guucguggag      300

gaggccaagc gccuccgggc ccgccaccuc cgggacuacc ccgacuacaa guaccgcccc      360

cggcgcaagg ccaagagcuc cggcgcgggc cccagccggu gcgggcaggg ccgcgggaac      420

cuggccuccg gcgggccgcu guggggcccc ggcuacgcca cgacccagcc cagccggggg      480

uucggcuacc ggcccccguc cuacagcacc gccuaccugc ccggguccua cggcagcagc      540

cacugcaagc uggaggcgcc cucccccugc agccucccgc aguccgaccc ccgccugcag      600

ggcgagcugc uccccaccua cacgcacuac cugcccccgg ggagccccac ccccuacaac      660

ccgccccugg ccggcgcccc caugccccuc acccaccugu ga                         702


<210>  10022
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Sox15__Homo_sapiens__AAH00985

<400>  10022
auggcccucc ccggcuccuc ccaggaccag gccugguccc ucgagccccc cgccgccacc       60

gccgccgccu ccuccuccuc cggcccccag gagcgcgagg gcgccggcuc ccccgccgcc      120

cccggcaccc ucccccucga gaaggucaag cgccccauga acgccuucau ggucuggucc      180

uccgcccagc gccgccagau ggcccagcag aaccccaaga ugcacaacuc cgagaucucc      240

aagcgccucg gcgcccagug gaagcuccuc gacgaggacg agaagcgccc cuucgucgag      300

gaggccaagc gccuccgcgc ccgccaccuc cgcgacuacc ccgacuacaa guaccgcccc      360

cgccgcaagg ccaaguccuc cggcgccggc cccucccgcu gcggccaggg ccgcggcaac      420

cucgccuccg gcggcccccu cuggggcccc ggcuacgcca ccacccagcc cucccgcggc      480

uucggcuacc gcccccccuc cuacuccacc gccuaccucc ccggcuccua cggcuccucc      540

cacugcaagc ucgaggcccc cucccccugc ucccuccccc aguccgaccc ccgccuccag      600

ggcgagcucc uccccaccua cacccacuac cucccccccg gcucccccac ccccuacaac      660

cccccccucg ccggcgcccc caugccccuc acccaccucu ga                         702


<210>  10023
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Sox15__Homo_sapiens__AAH00985

<400>  10023
auggcccugc ccggcagcuc ccaggaccag gcuuggucuc ucgagccucc agcagccacc       60

gcggcugccu caaguagcuc cgggccgcaa gaaagagagg gagcagguuc ucccgccgcu      120

ccuggcacac uuccacugga aaaggugaaa aggcccauga acgcauucau ggucuggucg      180

ucagcccagc ggcgccagau ggcucaacag aacccuaaga ugcacaacag cgagaucagu      240

aaacgauugg gggcccagug gaaguuacug gaugaagacg agaaacgucc auuuguugag      300

gaagcgaaga gacuaagggc acggcaucuc cgcgauuacc ccgacuauaa guacagaccu      360

aggcggaaag ccaaguccuc uggagcuggc ccaagccgcu gcggucaggg gcgaggaaau      420

cuggccuccg gcggcccgcu uugggggccc ggauaugcaa cuacgcaacc uucaagaggu      480

uucggcuaca ggccacccag uuauagcacc gcuuaccugc cugggucuua uggauccuca      540

cacuguaaau uggaggcccc aagccccugc agucucccgc agucugaucc ucggcugcag      600

ggcgaacugc uccccacaua cacucauuac uuaccaccug guucccccac cccauauaau      660

cccccucugg cgggggcccc aaugccgcuu acacacuugu ga                         702


<210>  10024
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Sox15__Homo_sapiens__AAH00985

<400>  10024
auggcccugc ccggcagcag ccaggaccag gccuggagcc uggagccccc cgccgccacc       60

gccgccgcca gcagcagcag cggcccccag gagagagagg gcgccggcag ccccgccgcc      120

cccggcaccc ugccccugga gaaggugaag agacccauga acgccuucau gguguggagc      180

agcgcccaga gaagacagau ggcccagcag aaccccaaga ugcacaacag cgagaucagc      240

aagagacugg gcgcccagug gaagcugcug gacgaggacg agaagagacc cuucguggag      300

gaggccaaga gacugagagc cagacaccug agagacuacc ccgacuacaa guacagaccc      360

agaagaaagg ccaagagcag cggcgccggc cccagcagau gcggccaggg cagaggcaac      420

cuggccagcg gcggcccccu guggggcccc ggcuacgcca ccacccagcc cagcagaggc      480

uucggcuaca gaccccccag cuacagcacc gccuaccugc ccggcagcua cggcagcagc      540

cacugcaagc uggaggcccc cagccccugc agccugcccc agagcgaccc cagacugcag      600

ggcgagcugc ugcccaccua cacccacuac cugccccccg gcagccccac ccccuacaac      660

cccccccugg ccggcgcccc caugccccug acccaccugu ga                         702


<210>  10025
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Sox15__Homo_sapiens__AAH00985

<400>  10025
auggcccugc ccggcagcuc ccaggaccag gcuuggucuc ucgagccucc ggccgcgacc       60

gcugccgcca gcuccucuag cgggccccaa gaaagagagg gagcuggcuc cccugccgcu      120

cccgggacac ugccucuuga aaaggugaaa cggcccauga acgccuucau ggucuggucu      180

agcgcgcagc gcagacagau ggcccaacag aauccuaaga ugcacaacuc cgagaucagc      240

aaacggcugg gagcucagug gaagcuccug gaugaagacg agaaacgccc guuuguugag      300

gaagccaaga gacuucgggc ucgccaucug agagauuacc ccgacuauaa guaccggccu      360

cgcagaaaag ccaagucuuc cggcgcgggg cccagccggu gcggacaggg ccgcggcaau      420

cucgccucug ggggaccucu guggggcccc ggguaugcua cgacccaacc guccagagga      480

uucggcuacc ggccucccag cuauucuaca gccuaccugc cuggguccua uggaagcucc      540

cacuguaaac ucgaggcucc cucucccugc agccugccuc aguccgaucc gcgccuucag      600

ggcgaacugc uccccaccua cacacauuac cugccucccg gcagcccuac ccccuauaac      660

ccgccucuug ccggggcccc caugccucug acacaccucu ga                         702


<210>  10026
<211>  702
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Sox15__Homo_sapiens__AAH00985

<400>  10026
auggcauuac caggaucauc ucaagaccaa gcauggucau uagaaccacc agcagcaaca       60

gcugcagcau caaguagcuc aggaccacaa gaaagagaag gagcaggcuc acccgcagca      120

ccaggaacau uaccacuaga aaaaguaaaa agacccauga acgcauucau ggucuggagc      180

ucagcacaaa gaagacaaau ggcccaacaa aauccaaaaa ugcacaauuc agaaauaucc      240

aaaagauuag gagcacaaug gaaauuauua gaugaagaug aaaaaagacc auuuguagaa      300

gaagcaaaaa gacuuagagc cagacaccua agagauuauc cagauuacaa auacagacca      360

agaagaaaag caaaaaguuc uggagcagga ccuagcagau guggacaagg aagaggaaac      420

cuagcaucag gaggaccccu auggggacca ggauacgcaa caacacaacc aucaagagga      480

uuuggauaua gaccaccauc uuacucaaca gcauacuuac caggaagcua uggaucaucc      540

cauugcaaac uagaagcacc aagcccaugu ucacuaccac aaucagaccc aagacuacaa      600

ggagaauuac uaccaacaua uacacauuac cuaccaccug gaucaccaac accauauaau      660

ccaccauuag caggagcacc aaugccacua acacacuuau aa                         702


<210>  10027
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Sox1__Homo_sapiens__O00570

<400>  10027

Met Tyr Ser Met Met Met Glu Thr Asp Leu His Ser Pro Gly Gly Ala 
1               5                   10                  15      


Gln Ala Pro Thr Asn Leu Ser Gly Pro Ala Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Lys Ala Asn Gln 
        35                  40                  45              


Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly 
    50                  55                  60                  


Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu 
65                  70                  75                  80  


Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Val Met Ser Glu Ala Glu 
                85                  90                  95      


Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met 
            100                 105                 110         


Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr 
        115                 120                 125             


Leu Leu Lys Lys Asp Lys Tyr Ser Leu Ala Gly Gly Leu Leu Ala Ala 
    130                 135                 140                 


Gly Ala Gly Gly Gly Gly Ala Ala Val Ala Met Gly Val Gly Val Gly 
145                 150                 155                 160 


Val Gly Ala Ala Ala Val Gly Gln Arg Leu Glu Ser Pro Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Gly Tyr Ala His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            180                 185                 190         


Pro Gly Ser Val Ala Ala Ala Ala Ala Ala Ala Ala Met Met Gln Glu 
        195                 200                 205             


Ala Gln Leu Ala Tyr Gly Gln His Pro Gly Ala Gly Gly Ala His Pro 
    210                 215                 220                 


His Ala His Pro Ala His Pro His Pro His His Pro His Ala His Pro 
225                 230                 235                 240 


His Asn Pro Gln Pro Met His Arg Tyr Asp Met Gly Ala Leu Gln Tyr 
                245                 250                 255     


Ser Pro Ile Ser Asn Ser Gln Gly Tyr Met Ser Ala Ser Pro Ser Gly 
            260                 265                 270         


Tyr Gly Gly Leu Pro Tyr Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Gly Ala His Gln Asn Ser Ala Val Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Gly Ala Leu Gly Ala Leu Gly Ser Leu Val Lys Ser 
305                 310                 315                 320 


Glu Pro Ser Gly Ser Pro Pro Ala Pro Ala His Ser Arg Ala Pro Cys 
                325                 330                 335     


Pro Gly Asp Leu Arg Glu Met Ile Ser Met Tyr Leu Pro Ala Gly Glu 
            340                 345                 350         


Gly Gly Asp Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Arg Leu 
        355                 360                 365             


His Ser Leu Pro Gln His Tyr Gln Gly Ala Gly Ala Gly Val Asn Gly 
    370                 375                 380                 


Thr Val Pro Leu Thr His Ile 
385                 390     


<210>  10028
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Sox1__Homo_sapiens__EAX09158

<400>  10028
auguacagca ugaugaugga gaccgaccug cacucgcccg gcggcgccca ggcccccacg       60

aaccucucgg gccccgccgg ggcgggcggc ggcgggggcg gaggcggggg cggcggcggc      120

ggcgggggcg ccaaggccaa ccaggaccgg gucaaacggc ccaugaacgc cuucauggug      180

uggucccgcg ggcagcggcg caagauggcc caggagaacc ccaagaugca caacucggag      240

aucagcaagc gccugggggc cgaguggaag gucauguccg aggccgagaa gcggccguuc      300

aucgacgagg ccaagcggcu gcgcgcgcug cacaugaagg agcacccgga uuacaaguac      360

cggccgcgcc gcaagaccaa gacgcugcuc aagaaggaca aguacucgcu ggccggcggg      420

cuccuggcgg ccggcgcggg uggcggcggc gcggcugugg ccaugggcgu gggcgugggc      480

gugggcgcgg cggccguggg ccagcgccug gagagcccag gcggcgcggc gggcggcggc      540

uacgcgcacg ucaacggcug ggccaacggc gccuaccccg gcucgguggc ggcggcggcg      600

gcggccgcgg ccaugaugca ggaggcgcag cuggccuacg ggcagcaccc gggcgcgggc      660

ggcgcgcacc cgcacgcgca ccccgcgcac ccgcacccgc accacccgca cgcgcacccg      720

cacaacccgc agcccaugca ccgcuacgac augggcgcgc ugcaguacag ccccaucucc      780

aacucgcagg gcuacaugag cgcgucgccc ucgggcuacg gcggccuccc cuacggcgcc      840

gcggccgccg ccgccgccgc ugcgggcggc gcgcaccaga acucggccgu ggcggcggcg      900

gcggcggcgg cggccgcguc gucgggcgcc cugggcgcgc ugggcucucu ggugaagucg      960

gagcccagcg gcagcccgcc cgccccagcg cacucgcggg cgccgugccc cggggaccug     1020

cgcgagauga ucagcaugua cuugcccgcc ggcgaggggg gcgacccggc ggcggcagca     1080

gcggccgcgg cgcagagccg gcugcacucg cugccgcagc acuaccaggg cgcgggcgcg     1140

ggcgugaacg gcacggugcc ccugacgcac aucuag                               1176


<210>  10029
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Sox1__Homo_sapiens__EAX09158

<400>  10029
auguacagca ugaugaugga gaccgaccug cacucccccg gcggggccca ggccccgacc       60

aaccucagcg gccccgcggg ggccggcggg ggcggcgggg gcgggggcgg gggcggcggg      120

ggcgggggcg ccaaggccaa ccaggaccgc gugaagcggc ccaugaacgc cuucaugguc      180

uggucccgcg gccagcggcg caagauggcg caggagaacc ccaagaugca caacagcgag      240

aucuccaagc ggcugggggc cgaguggaag gugaugagcg aggccgagaa gcgcccguuc      300

aucgacgagg ccaagcggcu gcgcgcgcuc cacaugaagg agcaccccga cuacaaguac      360

cggccccgcc ggaagacgaa gacccugcug aagaaggaca aguacucccu cgccggcggg      420

cugcuggccg ccggcgccgg gggcggcggg gcggccgugg ccaugggcgu cggggugggc      480

gugggggccg ccgcggucgg ccagcgccuc gagagccccg gcggggccgc cggcgggggc      540

uacgcccacg ugaacgggug ggccaacggc gcguacccgg gcuccguggc cgccgccgcc      600

gcggccgccg ccaugaugca ggaggcgcag cuggccuacg ggcagcaccc cggcgccggg      660

ggcgcccacc cccacgccca ccccgcgcac ccgcaccccc accaccccca cgcccacccc      720

cacaacccgc agcccaugca ccgguacgac augggcgccc ugcaguacag ccccaucucc      780

aacagccagg gguacauguc cgccagcccc uccggcuacg ggggccuccc guacggggcc      840

gcggccgccg ccgccgcggc cgccggcggc gcccaccaga acagcgcggu cgccgccgcc      900

gccgcggccg ccgccgccuc cagcggggcg cugggcgccc uggggucccu cgucaagagc      960

gagcccagcg gcuccccgcc cgcccccgcc cacagccgcg cccccugccc cggggaccug     1020

cgggagauga ucuccaugua ccugcccgcg ggcgagggcg gggacccggc cgccgccgcg     1080

gccgccgccg cccagagccg ccuccacucc cugccccagc acuaccaggg cgcgggggcc     1140

ggcgugaacg ggaccgugcc ccugacccac aucuga                               1176


<210>  10030
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Sox1__Homo_sapiens__EAX09158

<400>  10030
auguacucca ugaugaugga gaccgaccuc cacucccccg gcggcgccca ggcccccacc       60

aaccucuccg gccccgccgg cgccggcggc ggcggcggcg gcggcggcgg cggcggcggc      120

ggcggcggcg ccaaggccaa ccaggaccgc gucaagcgcc ccaugaacgc cuucaugguc      180

uggucccgcg gccagcgccg caagauggcc caggagaacc ccaagaugca caacuccgag      240

aucuccaagc gccucggcgc cgaguggaag gucauguccg aggccgagaa gcgccccuuc      300

aucgacgagg ccaagcgccu ccgcgcccuc cacaugaagg agcaccccga cuacaaguac      360

cgcccccgcc gcaagaccaa gacccuccuc aagaaggaca aguacucccu cgccggcggc      420

cuccucgccg ccggcgccgg cggcggcggc gccgccgucg ccaugggcgu cggcgucggc      480

gucggcgccg ccgccgucgg ccagcgccuc gagucccccg gcggcgccgc cggcggcggc      540

uacgcccacg ucaacggcug ggccaacggc gccuaccccg gcuccgucgc cgccgccgcc      600

gccgccgccg ccaugaugca ggaggcccag cucgccuacg gccagcaccc cggcgccggc      660

ggcgcccacc cccacgccca ccccgcccac ccccaccccc accaccccca cgcccacccc      720

cacaaccccc agcccaugca ccgcuacgac augggcgccc uccaguacuc ccccaucucc      780

aacucccagg gcuacauguc cgccuccccc uccggcuacg gcggccuccc cuacggcgcc      840

gccgccgccg ccgccgccgc cgccggcggc gcccaccaga acuccgccgu cgccgccgcc      900

gccgccgccg ccgccgccuc cuccggcgcc cucggcgccc ucggcucccu cgucaagucc      960

gagcccuccg gcuccccccc cgcccccgcc cacucccgcg cccccugccc cggcgaccuc     1020

cgcgagauga ucuccaugua ccuccccgcc ggcgagggcg gcgaccccgc cgccgccgcc     1080

gccgccgccg cccagucccg ccuccacucc cucccccagc acuaccaggg cgccggcgcc     1140

ggcgucaacg gcaccguccc ccucacccac aucuga                               1176


<210>  10031
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Sox1__Homo_sapiens__EAX09158

<400>  10031
auguacagca ugaugaugga gaccgaccug cacucccccg gcggggccca ggcuccuaca       60

aaccucucug gaccagccgg ugcaggcggg ggaggcggug ggggaggcgg cgggggaggu      120

ggcgggggag cgaaggcuaa ucaagauaga gugaaaaggc cgaugaacgc cuucaugguc      180

uggucacggg gccagcgccg aaagauggca caggaaaauc ccaaaaugca uaacagugag      240

aucagcaagc gucuuggugc cgaauggaaa guuauguccg aggcugaaaa gagaccuuuu      300

auugacgagg caaagaggcu gcgggccuug cacaugaaag agcauccaga uuauaaguac      360

cgccccagaa ggaaaacuaa gacguuacug aaaaaggaca aguauucucu agcuggggga      420

cuccuggccg cgggcgcagg cgggggaggu gccgcugugg ccaugggcgu agggguggga      480

gucggcgcag cugccguggg ucagcggcuu gaaucgccug ggggcgcggc cggaggcggg      540

uacgcacacg uuaauggaug ggcuaacggu gccuauccag gcucaguggc ugccgcagcc      600

gcugcggcag ccaugaugca agaggcucag cuggccuacg ggcagcaucc cggagcaggc      660

ggugcccacc cucacgcuca uccagcccac ccgcaucccc accacccuca ugcacaccca      720

cauaaucccc agccuaugca ccgcuaugau augggggcgu ugcaauacag cccaauaagu      780

aacucccagg gcuacauguc ugcuagcccc uccggauaug gcgggcuccc guacggagcc      840

gcagccgcug ccgcagcugc cgcggguggc gcccaucaga auagcgcugu cgcagccgcu      900

gccgcagcgg ccgcugccag uagcggggca cugggagcuc ugggcucucu cgugaaaucc      960

gaaccuucag guucaccccc agccccugca cacagucgag cccccugccc aggggacuua     1020

agagagauga ucucuaugua ucugcccgcu ggcgagggag gcgauccugc ggccgcagcu     1080

gccgccgcug cacaguccag gcuucacagc uugccacaac auuaccaggg ggccggagcg     1140

ggcguaaacg guaccguucc gcugacacac auuuga                               1176


<210>  10032
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Sox1__Homo_sapiens__EAX09158

<400>  10032
auguacagca ugaugaugga gaccgaccug cacagccccg gcggcgccca ggcccccacc       60

aaccugagcg gccccgccgg cgccggcggc ggcggcggcg gcggcggcgg cggcggcggc      120

ggcggcggcg ccaaggccaa ccaggacaga gugaagagac ccaugaacgc cuucauggug      180

uggagcagag gccagagaag aaagauggcc caggagaacc ccaagaugca caacagcgag      240

aucagcaaga gacugggcgc cgaguggaag gugaugagcg aggccgagaa gagacccuuc      300

aucgacgagg ccaagagacu gagagcccug cacaugaagg agcaccccga cuacaaguac      360

agacccagaa gaaagaccaa gacccugcug aagaaggaca aguacagccu ggccggcggc      420

cugcuggccg ccggcgccgg cggcggcggc gccgccgugg ccaugggcgu gggcgugggc      480

gugggcgccg ccgccguggg ccagagacug gagagccccg gcggcgccgc cggcggcggc      540

uacgcccacg ugaacggcug ggccaacggc gccuaccccg gcagcguggc cgccgccgcc      600

gccgccgccg ccaugaugca ggaggcccag cuggccuacg gccagcaccc cggcgccggc      660

ggcgcccacc cccacgccca ccccgcccac ccccaccccc accaccccca cgcccacccc      720

cacaaccccc agcccaugca cagauacgac augggcgccc ugcaguacag ccccaucagc      780

aacagccagg gcuacaugag cgccagcccc agcggcuacg gcggccugcc cuacggcgcc      840

gccgccgccg ccgccgccgc cgccggcggc gcccaccaga acagcgccgu ggccgccgcc      900

gccgccgccg ccgccgccag cagcggcgcc cugggcgccc ugggcagccu ggugaagagc      960

gagcccagcg gcagcccccc cgcccccgcc cacagcagag cccccugccc cggcgaccug     1020

agagagauga ucagcaugua ccugcccgcc ggcgagggcg gcgaccccgc cgccgccgcc     1080

gccgccgccg cccagagcag acugcacagc cugccccagc acuaccaggg cgccggcgcc     1140

ggcgugaacg gcaccgugcc ccugacccac aucuga                               1176


<210>  10033
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Sox1__Homo_sapiens__EAX09158

<400>  10033
auguacagca ugaugaugga gaccgaccug cacucccccg gcggggccca ggcuccuaca       60

aaccucucug gaccggccgg cgcuggggga ggcgggggag gcggcggggg aggcggggga      120

ggcgggggag cgaaggccaa ucaagauaga gugaaacggc ccaugaacgc cuucaugguc      180

uggagccgcg gccagagacg gaagauggcu caggaaaauc cuaaaaugca uaacuccgag      240

aucucuaagc gccugggcgc cgaauggaaa guuaugagcg aggcugaaaa gagacccuuu      300

auugacgagg ccaagcggcu ucgcgcgcug cacaugaaag agcauccuga uuauaaguac      360

agaccccggc gcaaaacgaa gacccuccug aaaaaggaca aguauucccu ugccggggga      420

cugcucgcug ccggcgcugg gggaggcggg gccgcggugg ccaugggagu gggcgucggc      480

gugggggcug ccgcuguugg acagagacug gaaucuccug gcggggccgc cggaggcggg      540

uacgcucacg ugaauggcug ggcgaacgga gccuauccgg gcagcgucgc ugccgccgcu      600

gccgcggcug ccaugaugca agaggcccag cuggcuuacg ggcagcaucc cggagccggc      660

ggggcucacc cucacgccca ucccgcgcac ccucaucccc accacccgca ugcccacccu      720

cauaaucccc agccuaugca ccgguaugau augggagcuc uccaauacuc ccccaucagc      780

aacucucagg gcuacauguc cgccagcccc ucuggguaug gcggacugcc uuacggcgcu      840

gccgcggccg cugccgcugc cgccggggga gcucaucaaa auuccgcggu ggccgcugcc      900

gccgcugccg cggcugccag cucuggcgcc cuuggggcuc ugggaucccu cguuaaaagc      960

gaaccguccg gcucuccccc ugcccccgcg cacagccgcg cuccuugccc cggggaccug     1020

agagagauga uuuccaugua ucuuccggcc ggcgagggag gcgauccugc cgcugccgcu     1080

gccgcggccg cucagagccg gcugcacucu cucccccagc auuaccaggg ggccggagcu     1140

ggcgugaacg ggacaguccc ucugacccac aucuga                               1176


<210>  10034
<211>  1176
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Sox1__Homo_sapiens__EAX09158

<400>  10034
auguauagua ugaugaugga aacugauuua cauaguccag gaggagcuca agcaccgaca       60

aaucugagug ggccugcagg agcuggagga ggagggggag guggaggagg aggaggagga      120

ggaggaggug caaaagcaaa ccaggacaga guaaaaagac cgaugaacgc auucauggua      180

uggagucgag gacaaagaag aaaaauggca caagaaaacc caaaaaugca caauagcgaa      240

auaucaaaaa gauuaggggc agaauggaaa guaauguccg aagcagaaaa aagaccauuu      300

auagaugaag cgaaaagauu aagggcacuu cauaugaaag aacacccaga uuauaaauau      360

agaccaagga gaaaaacuaa aacauuauua aaaaaagaua aauauaguuu agcgggagga      420

cuauuagcag caggagcugg aggaggaggu gcagcaguag caaugggggu aggaguagga      480

guaggagccg cagcaguugg ucaaagauug gaaaguccag ggggagcugc aggaggagga      540

uacgcucacg uaaaugguug ggcaaaugga gcauauccag gaaguguagc agcagcagca      600

gcagcagcag caaugaugca agaagcacaa cuagcuuaug gacaacaucc aggagcaggg      660

ggagcucauc cacacgcaca uccagcacau ccucacccac accauccaca ugcacauccu      720

cauaauccac agccaaugca uagauacgau augggugcau uacaauacag cccaauaagu      780

aauucacaag gauauauguc agcaucaccu ucaggauaug gaggacuacc auauggagca      840

gcggcagcag cagccgcagc agcaggagga gcacaucaaa auagugcagu ugcggcagcg      900

gcagcggcag cagcagcauc uucaggagcu uuaggagcau uaggaucauu aguuaaauca      960

gaaccaagcg gaaguccacc agcaccugca cauaguagag caccaugucc uggagauuua     1020

agagagauga uaaguaugua uuuaccugca ggagaaggag gagauccagc agcagcagca     1080

gcagcagcag cacaaaguag auuacauucg cuaccacaac auuaucaagg agcaggugca     1140

ggaguaaaug gaacuguacc auuaacacau auuuaa                               1176


<210>  10035
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Sox2__Homo_sapiens__P48431

<400>  10035

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  10036
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Sox2__Homo_sapiens__AAH13923

<400>  10036
auguacaaca ugauggagac ggagcugaag ccgccgggcc cgcagcaaac uucggggggc       60

ggcggcggca acuccaccgc ggcggcggcc ggcggcaacc agaaaaacag cccggaccgc      120

gucaagcggc ccaugaaugc cuucauggug uggucccgcg ggcagcggcg caagauggcc      180

caggagaacc ccaagaugca caacucggag aucagcaagc gccugggcgc cgaguggaaa      240

cuuuugucgg agacggagaa gcggccguuc aucgacgagg cuaagcggcu gcgagcgcug      300

cacaugaagg agcacccgga uuauaaauac cggccccggc ggaaaaccaa gacgcucaug      360

aagaaggaua aguacacgcu gcccggcggg cugcuggccc ccggcggcaa uagcauggcg      420

agcggggucg gggugggcgc cggccugggc gcgggcguga accagcgcau ggacaguuac      480

gcgcacauga acggcuggag caacggcagc uacagcauga ugcaggacca gcugggcuac      540

ccgcagcacc cgggccucaa ugcgcacggc gcagcgcaga ugcagcccau gcaccgcuac      600

gacgugagcg cccugcagua caacuccaug accagcucgc agaccuacau gaacggcucg      660

cccaccuaca gcauguccua cucgcagcag ggcaccccug gcauggcucu uggcuccaug      720

gguucggugg ucaaguccga ggccagcucc agccccccug ugguuaccuc uuccucccac      780

uccagggcgc ccugccaggc cggggaccuc cgggacauga ucagcaugua ucuccccggc      840

gccgaggugc cggaacccgc cgcccccagc agacuucaca ugucccagca cuaccagagc      900

ggcccggugc ccggcacggc cauuaacggc acacugcccc ucucacacau guga            954


<210>  10037
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Sox2__Homo_sapiens__AAH13923

<400>  10037
auguacaaca ugauggagac cgagcugaag cccccgggcc cccagcagac cagcgggggc       60

gggggcggga acuccacggc cgccgcggcc ggcggcaacc agaagaacag ccccgaccgc      120

gugaagcggc ccaugaacgc cuucaugguc uggucccgcg ggcagcggcg caagauggcc      180

caggagaacc cgaagaugca caacagcgag aucuccaagc ggcucggcgc cgaguggaag      240

cugcugagcg agaccgagaa gcgccccuuc aucgacgagg cgaagcggcu ccgcgcccug      300

cacaugaagg agcaccccga cuacaaguac cggccccgcc ggaagaccaa gacccugaug      360

aagaaggaca aguacacgcu ccccgggggc cugcuggccc ccgggggcaa cuccauggcc      420

agcggcgugg gggugggcgc ggggcucggc gccggcguca accagcgcau ggacuccuac      480

gcccacauga acggguggag caacggcucc uacagcauga ugcaggacca gcugggguac      540

ccccagcacc ccggccugaa cgcccacggg gccgcgcaga ugcagccgau gcaccgguac      600

gacguguccg cccuccagua caacagcaug accuccagcc agaccuacau gaacggcucc      660

cccaccuaca gcauguccua cagccagcag ggcacgcccg ggauggcccu gggcagcaug      720

ggguccgugg ucaagagcga ggccuccagc uccccgccgg uggugaccag cuccagccac      780

ucccgcgccc ccugccaggc gggcgaccug cgggacauga ucagcaugua ccuccccggg      840

gccgaggucc ccgagccggc cgcccccucc cgccugcaca ugagccagca cuaccagucc      900

ggccccgugc ccggcaccgc caucaacggg acccugccgc ucagccacau guga            954


<210>  10038
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Sox2__Homo_sapiens__AAH13923

<400>  10038
auguacaaca ugauggagac cgagcucaag ccccccggcc cccagcagac cuccggcggc       60

ggcggcggca acuccaccgc cgccgccgcc ggcggcaacc agaagaacuc ccccgaccgc      120

gucaagcgcc ccaugaacgc cuucaugguc uggucccgcg gccagcgccg caagauggcc      180

caggagaacc ccaagaugca caacuccgag aucuccaagc gccucggcgc cgaguggaag      240

cuccucuccg agaccgagaa gcgccccuuc aucgacgagg ccaagcgccu ccgcgcccuc      300

cacaugaagg agcaccccga cuacaaguac cgcccccgcc gcaagaccaa gacccucaug      360

aagaaggaca aguacacccu ccccggcggc cuccucgccc ccggcggcaa cuccauggcc      420

uccggcgucg gcgucggcgc cggccucggc gccggcguca accagcgcau ggacuccuac      480

gcccacauga acggcugguc caacggcucc uacuccauga ugcaggacca gcucggcuac      540

ccccagcacc ccggccucaa cgcccacggc gccgcccaga ugcagcccau gcaccgcuac      600

gacgucuccg cccuccagua caacuccaug accuccuccc agaccuacau gaacggcucc      660

cccaccuacu ccauguccua cucccagcag ggcacccccg gcauggcccu cggcuccaug      720

ggcuccgucg ucaaguccga ggccuccucc uccccccccg ucgucaccuc cuccucccac      780

ucccgcgccc ccugccaggc cggcgaccuc cgcgacauga ucuccaugua ccuccccggc      840

gccgaggucc ccgagcccgc cgcccccucc cgccuccaca ugucccagca cuaccagucc      900

ggccccgucc ccggcaccgc caucaacggc acccuccccc ucucccacau guga            954


<210>  10039
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Sox2__Homo_sapiens__AAH13923

<400>  10039
auguacaaca ugauggagac cgaacugaag cccccuggcc cacagcaaac aagcggggga       60

gguggcggaa auuccacugc cgcugcagcc gggggcaacc agaaaaauuc uccggacaga      120

gugaagaggc ccaugaacgc guucaugguc uggucacggg gucagcgccg aaaaauggcu      180

caggagaauc cuaagaugca caacagugaa aucagcaaac gucucggggc cgaguggaaa      240

cuucuguccg aaacggagaa gagaccauuu auugaugagg caaagagguu gcgggccuua      300

cauaugaagg aacaccccga cuauaaauac cgcccuagaa ggaagaccaa aacacugaug      360

aagaaggaua aauauacucu accaggaggc cuccuggcuc ccggcggaaa uucuauggca      420

ucggggguug gugugggcgc cgggcuugga gcuggcguaa accaacggau ggacucauac      480

gcccauauga augguuggag caacgggagu uauuccauga ugcaggauca gcugggauac      540

ccucagcacc caggcuugaa ugcgcauggc gcagcccaaa ugcagccgau gcaccgcuau      600

gacgugucug cucuccagua caacagcaug accuccucac agacauacau gaaugggagu      660

cccaccuaua gcaugucuua cucccaacag ggaacuccug guauggcccu gggcucaaug      720

gggagcgucg ugaagaguga ggcaucuucc agcccacccg uugugacauc gucuucccac      780

ucacgagcuc cuugccaggc cggagaucug agagacauga uaaguaugua ucucccaggc      840

gcggaagucc ccgagccggc cgcaccuagc agguuacaua ugucccaaca cuaccagucu      900

ggucccgugc cagggaccgc uaucaacggc acgcugccuc uuagccauau guga            954


<210>  10040
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Sox2__Homo_sapiens__AAH13923

<400>  10040
auguacaaca ugauggagac cgagcugaag ccccccggcc cccagcagac cagcggcggc       60

ggcggcggca acagcaccgc cgccgccgcc ggcggcaacc agaagaacag ccccgacaga      120

gugaagagac ccaugaacgc cuucauggug uggagcagag gccagagaag aaagauggcc      180

caggagaacc ccaagaugca caacagcgag aucagcaaga gacugggcgc cgaguggaag      240

cugcugagcg agaccgagaa gagacccuuc aucgacgagg ccaagagacu gagagcccug      300

cacaugaagg agcaccccga cuacaaguac agacccagaa gaaagaccaa gacccugaug      360

aagaaggaca aguacacccu gcccggcggc cugcuggccc ccggcggcaa cagcauggcc      420

agcggcgugg gcgugggcgc cggccugggc gccggcguga accagagaau ggacagcuac      480

gcccacauga acggcuggag caacggcagc uacagcauga ugcaggacca gcugggcuac      540

ccccagcacc ccggccugaa cgcccacggc gccgcccaga ugcagcccau gcacagauac      600

gacgugagcg cccugcagua caacagcaug accagcagcc agaccuacau gaacggcagc      660

cccaccuaca gcaugagcua cagccagcag ggcacccccg gcauggcccu gggcagcaug      720

ggcagcgugg ugaagagcga ggccagcagc agcccccccg uggugaccag cagcagccac      780

agcagagccc ccugccaggc cggcgaccug agagacauga ucagcaugua ccugcccggc      840

gccgaggugc ccgagcccgc cgcccccagc agacugcaca ugagccagca cuaccagagc      900

ggccccgugc ccggcaccgc caucaacggc acccugcccc ugagccacau guga            954


<210>  10041
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Sox2__Homo_sapiens__AAH13923

<400>  10041
auguacaaca ugauggagac cgaacugaag cccccuggcc cgcagcaaac aagcggggga       60

ggcgggggaa auuccacggc cgcugccgcg ggcgggaacc agaaaaauuc ucccgacaga      120

gugaagcggc cuaugaacgc uuucaugguc uggagccgcg gacagagacg gaaaauggcc      180

caggagaauc ccaagaugca caacuccgaa aucucuaaac gccucggcgc cgaguggaag      240

cugcuuagcg aaaccgagaa gagaccuuuu auugaugagg cuaaacggcu gcgcgcccuc      300

cauaugaagg aacaccccga cuauaaauac agaccucggc gcaagacaaa aacccugaug      360

aagaaggaua aauauacacu uccgggcggg cugcucgcuc ccggaggcaa uuccauggcc      420

ucugggguug gagugggcgc ggggcuggga gccggcguga accaaagaau ggacagcuac      480

gcucauauga auggcugguc caacgggagc uauucuauga ugcaggauca gcugggauac      540

ccucagcacc ccggccucaa ugcccauggg gcugcccaaa ugcagccuau gcaccgguau      600

gacgucuccg cgcugcagua caacagcaug accucuuccc agacauacau gaauggaagc      660

cccaccuauu cuauguccua cagccaacag ggcacgccgg ggauggcccu uggauccaug      720

ggcucugugg uuaagagcga ggcuuccagc ucuccucccg uggucaccuc cagcucucac      780

agccgcgccc cuugccaggc uggcgaucug agagacauga ucuccaugua ucuccccggg      840

gccgaagugc ccgagccugc cgcuccgucu cggcugcaua ugagccaaca cuaccagucc      900

ggacccguuc cuggcacagc gauuaacggg acccuucccc ugagccauau guga            954


<210>  10042
<211>  954
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Sox2__Homo_sapiens__AAH13923

<400>  10042
auguacaaca ugauggaaac agaauuaaaa ccaccaggac cacaacaaac aucaggcgga       60

ggaggaggaa auucaacagc agcagcggca ggaggaaauc aaaaaaacag cccagauaga      120

guaaaaagac caaugaaugc auucauggua uggagccgag gacaaagaag aaaaauggca      180

caagaaaacc caaaaaugca caacucagaa auaagcaaaa gacuaggagc agaauggaaa      240

uuacuaucag aaacagaaaa acgaccauuc auagacgaag caaaaagacu acgagcauua      300

cacaugaaag aacaucccga cuauaaauau agaccaagaa gaaagacaaa aacacuaaug      360

aaaaaagaua aauauacauu accaggagga cuauuagccc caggaggaaa cucaauggca      420

ucaggaguug gaguuggagc aggacuagga gcaggaguaa aucaaagaau ggauucauac      480

gcacacauga acggaugguc aaacggauca uauucaauga ugcaagacca auuaggauac      540

ccacaacauc caggauuaaa cgcacaugga gcagcacaaa ugcaacccau gcacagauac      600

gauguaucag cacuucaaua uaacucaaug acaagcucac aaacauacau gaacggauca      660

ccaacauauu cuaugagcua uagccaacaa gguacaccug gaauggcacu gggaaguaug      720

ggaucaguag uaaaaagcga agcaucauca ucaccaccag uaguaacauc aucaucccac      780

aguagagcac caugucaagc aggagauuua agagacauga uaucaaugua ucuaccagga      840

gcagaaguac cagaaccagc agcaccaagc agauuacaua ugucacaaca uuaccaaagu      900

ggaccaguac caggaacagc aauaaaugga acacuaccau uaucacacau guaa            954


<210>  10043
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Sox3__Homo_sapiens__P41225

<400>  10043

Met Arg Pro Val Arg Glu Asn Ser Ser Gly Ala Arg Ser Pro Arg Val 
1               5                   10                  15      


Pro Ala Asp Leu Ala Arg Ser Ile Leu Ile Ser Leu Pro Phe Pro Pro 
            20                  25                  30          


Asp Ser Leu Ala His Arg Pro Pro Ser Ser Ala Pro Thr Glu Ser Gln 
        35                  40                  45              


Gly Leu Phe Thr Val Ala Ala Pro Ala Pro Gly Ala Pro Ser Pro Pro 
    50                  55                  60                  


Ala Thr Leu Ala His Leu Leu Pro Ala Pro Ala Met Tyr Ser Leu Leu 
65                  70                  75                  80  


Glu Thr Glu Leu Lys Asn Pro Val Gly Thr Pro Thr Gln Ala Ala Gly 
                85                  90                  95      


Thr Gly Gly Pro Ala Ala Pro Gly Gly Ala Gly Lys Ser Ser Ala Asn 
            100                 105                 110         


Ala Ala Gly Gly Ala Asn Ser Gly Gly Gly Ser Ser Gly Gly Ala Ser 
        115                 120                 125             


Gly Gly Gly Gly Gly Thr Asp Gln Asp Arg Val Lys Arg Pro Met Asn 
    130                 135                 140                 


Ala Phe Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Leu Glu 
145                 150                 155                 160 


Asn Pro Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Asp 
                165                 170                 175     


Trp Lys Leu Leu Thr Asp Ala Glu Lys Arg Pro Phe Ile Asp Glu Ala 
            180                 185                 190         


Lys Arg Leu Arg Ala Val His Met Lys Glu Tyr Pro Asp Tyr Lys Tyr 
        195                 200                 205             


Arg Pro Arg Arg Lys Thr Lys Thr Leu Leu Lys Lys Asp Lys Tyr Ser 
    210                 215                 220                 


Leu Pro Ser Gly Leu Leu Pro Pro Gly Ala Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Gly Val Gly Gln 
                245                 250                 255     


Arg Leu Asp Thr Tyr Thr His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            260                 265                 270         


Ser Leu Val Gln Glu Gln Leu Gly Tyr Ala Gln Pro Pro Ser Met Ser 
        275                 280                 285             


Ser Pro Pro Pro Pro Pro Ala Leu Pro Pro Met His Arg Tyr Asp Met 
    290                 295                 300                 


Ala Gly Leu Gln Tyr Ser Pro Met Met Pro Pro Gly Ala Gln Ser Tyr 
305                 310                 315                 320 


Met Asn Val Ala Ala Ala Ala Ala Ala Ala Ser Gly Tyr Gly Gly Met 
                325                 330                 335     


Ala Pro Ser Ala Thr Ala Ala Ala Ala Ala Ala Tyr Gly Gln Gln Pro 
            340                 345                 350         


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Met Ser Leu Gly 
        355                 360                 365             


Pro Met Gly Ser Val Val Lys Ser Glu Pro Ser Ser Pro Pro Pro Ala 
    370                 375                 380                 


Ile Ala Ser His Ser Gln Arg Ala Cys Leu Gly Asp Leu Arg Asp Met 
385                 390                 395                 400 


Ile Ser Met Tyr Leu Pro Pro Gly Gly Asp Ala Ala Asp Ala Ala Ser 
                405                 410                 415     


Pro Leu Pro Gly Gly Arg Leu His Gly Val His Gln His Tyr Gln Gly 
            420                 425                 430         


Ala Gly Thr Ala Val Asn Gly Thr Val Pro Leu Thr His Ile 
        435                 440                 445     


<210>  10044
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Sox3__Homo_sapiens__AAF73059

<400>  10044
augcgaccug uucgagagaa cucaucaggu gcgagaagcc cgcggguucc ugcugauuug       60

gcgcggagca uuuugauaag ccuacccuuc ccgccggacu cgcuggccca caggccccca      120

agcuccgcuc cgacggaguc ccagggccuu uucaccgugg ccgcuccagc cccgggagcg      180

ccuucuccuc ccgccacgcu ggcgcaccuu cuucccgccc cggcaaugua cagccuucug      240

gagacugaac ucaagaaccc cguagggaca cccacacaag cggcgggcac cggcggcccc      300

gcagccccgg gaggcgcagg caagaguagu gcgaacgcag ccggcggcgc gaacucgggc      360

ggcggcagca gcgguggugc gagcggaggu ggcgggggua cagaccagga ccgugugaaa      420

cggcccauga acgccuucau gguauggucc cgcgggcagc ggcgcaaaau ggcccuggag      480

aaccccaaga ugcacaauuc ugagaucagc aagcgcuugg gcgccgacug gaaacugcug      540

accgacgccg agaagcgacc auucaucgac gaggccaagc gacuucgcgc cgugcacaug      600

aaggaguauc cggacuacaa guaccgaccg cgccgcaaga ccaagacgcu gcucaagaaa      660

gauaaguacu cccugcccag cggccuccug ccucccggug ccgcggccgc cgccgccgcu      720

gccgcggccg cagccgcugc cgccagcagu ccggugggcg ugggccagcg ccuggacacg      780

uacacgcacg ugaacggcug ggccaacggc gcguacucgc uggugcagga gcagcugggc      840

uacgcgcagc ccccgagcau gagcagcccg ccgccgccgc ccgcgcugcc gccgaugcac      900

cgcuacgaca uggccggccu gcaguacagc ccaaugaugc cgcccggcgc ucagagcuac      960

augaacgucg cugccgcggc cgccgccgcc ucgggcuacg ggggcauggc gcccucagcc     1020

acagcagccg cggccgccgc cuacgggcag cagcccgcca ccgccgcggc cgcagcugcg     1080

gccgcagccg ccaugagccu gggccccaug ggcucgguag ugaagucuga gcccagcucg     1140

ccgccgcccg ccaucgcauc gcacucucag cgcgcgugcc ucggcgaccu gcgcgacaug     1200

aucagcaugu accugccacc cggcggggac gcggccgacg ccgccucucc gcugcccggc     1260

ggucgccugc acggcgugca ccagcacuac cagggcgccg ggacugcagu caacggaacg     1320

gugccgcuga cccacaucug a                                               1341


<210>  10045
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt1 from
       Sox3__Homo_sapiens__AAF73059

<400>  10045
augcgccccg ugcgggagaa cagcuccggc gcccgcagcc cgcggguccc cgccgaccug       60

gcgcgcucca uccucaucag ccugcccuuc cccccggacu cccuggccca ccggcccccc      120

agcuccgccc ccaccgagag ccaggggcuc uucaccgugg ccgccccggc gcccggcgcc      180

cccucccccc cggccacgcu ggcccaccug cuccccgcgc ccgccaugua cagccugcug      240

gagaccgagc ucaagaaccc cguggggacc ccgacccagg ccgccggcac ggggggcccc      300

gccgcgcccg gcggggccgg caaguccagc gccaacgccg ccgggggcgc gaacuccggg      360

ggcggcagcu ccgggggcgc cagcgggggc ggcgggggca ccgaccagga ccgcgucaag      420

cggcccauga acgccuucau gguguggucc cgcgggcagc ggcgcaagau ggcccuggag      480

aacccgaaga ugcacaacag cgagaucucc aagcggcugg gcgccgacug gaagcuccug      540

accgacgcgg agaagcgccc cuucaucgac gaggccaagc ggcugcgcgc cgugcacaug      600

aaggaguacc ccgacuacaa guaccggccc cgccggaaga ccaagacgcu ccugaagaag      660

gacaaguaca gccugccgag cgggcuccug ccccccggcg ccgccgcggc cgccgccgcg      720

gccgccgccg ccgcggccgc cgccuccagc cccgucggcg uggggcagcg ccuggacacc      780

uacacccacg ugaacggcug ggccaacggg gcguacuccc ucguccagga gcagcugggc      840

uacgcccagc cgcccagcau guccagcccc ccgccccccc ccgcccugcc gcccaugcac      900

cgguacgaca uggccgggcu ccaguacucc cccaugaugc ccccgggcgc ccagagcuac      960

augaacgugg cggccgccgc cgcggccgcc uccggcuacg ggggcauggc ccccagcgcc     1020

accgcggccg ccgccgccgc guacgggcag cagcccgcca cggccgccgc cgcggccgcc     1080

gccgcggccg ccaugucccu gggccccaug gggagcgugg ucaaguccga gccgagcucc     1140

cccccccccg ccaucgccag ccacucccag cgcgcgugcc ugggcgaccu ccgggacaug     1200

aucagcaugu accugccgcc cggcggggac gccgccgacg ccgccucccc ccugcccggc     1260

gggcgccucc acggcgugca ccagcacuac cagggcgcgg ggaccgccgu gaacggcacc     1320

gucccgcuga cccacaucug a                                               1341


<210>  10046
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt2 from
       Sox3__Homo_sapiens__AAF73059

<400>  10046
augcgccccg uccgcgagaa cuccuccggc gcccgcuccc cccgcguccc cgccgaccuc       60

gcccgcucca uccucaucuc ccuccccuuc ccccccgacu cccucgccca ccgccccccc      120

uccuccgccc ccaccgaguc ccagggccuc uucaccgucg ccgcccccgc ccccggcgcc      180

cccucccccc ccgccacccu cgcccaccuc cuccccgccc ccgccaugua cucccuccuc      240

gagaccgagc ucaagaaccc cgucggcacc cccacccagg ccgccggcac cggcggcccc      300

gccgcccccg gcggcgccgg caaguccucc gccaacgccg ccggcggcgc caacuccggc      360

ggcggcuccu ccggcggcgc cuccggcggc ggcggcggca ccgaccagga ccgcgucaag      420

cgccccauga acgccuucau ggucuggucc cgcggccagc gccgcaagau ggcccucgag      480

aaccccaaga ugcacaacuc cgagaucucc aagcgccucg gcgccgacug gaagcuccuc      540

accgacgccg agaagcgccc cuucaucgac gaggccaagc gccuccgcgc cguccacaug      600

aaggaguacc ccgacuacaa guaccgcccc cgccgcaaga ccaagacccu ccucaagaag      660

gacaaguacu cccuccccuc cggccuccuc ccccccggcg ccgccgccgc cgccgccgcc      720

gccgccgccg ccgccgccgc cgccuccucc cccgucggcg ucggccagcg ccucgacacc      780

uacacccacg ucaacggcug ggccaacggc gccuacuccc ucguccagga gcagcucggc      840

uacgcccagc cccccuccau guccuccccc cccccccccc ccgcccuccc ccccaugcac      900

cgcuacgaca uggccggccu ccaguacucc cccaugaugc cccccggcgc ccaguccuac      960

augaacgucg ccgccgccgc cgccgccgcc uccggcuacg gcggcauggc ccccuccgcc     1020

accgccgccg ccgccgccgc cuacggccag cagcccgcca ccgccgccgc cgccgccgcc     1080

gccgccgccg ccaugucccu cggccccaug ggcuccgucg ucaaguccga gcccuccucc     1140

cccccccccg ccaucgccuc ccacucccag cgcgccugcc ucggcgaccu ccgcgacaug     1200

aucuccaugu accucccccc cggcggcgac gccgccgacg ccgccucccc ccuccccggc     1260

ggccgccucc acggcgucca ccagcacuac cagggcgccg gcaccgccgu caacggcacc     1320

gucccccuca cccacaucug a                                               1341


<210>  10047
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt3 from
       Sox3__Homo_sapiens__AAF73059

<400>  10047
augagacccg ugagggagaa cagcuccggc gcccggucuc cucgcguccc agcugaccug       60

gcacgaucaa uccucauuag ucuuccguuu cccccugaua gccuggccca ccguccaccc      120

uccucugcgc cuaccgaauc gcagggguug uucacaguug cugccccagc acccggagcc      180

ccuucaccac cggcuacuuu agcacaucug cuacccgccc cugcuaugua cagccuccug      240

gagacggaac uuaagaaucc aguggguacc cccacacaag ccgcgggcac ugggggaccu      300

gcagccccag gcggugcugg gaaaaguucc gccaacgcag cuggaggcgc caauucuggc      360

gggggaagcu ccgguggcgc gucaggggga ggcgguggga ccgaccagga uagaguaaag      420

aggcccauga acgccuucau gguguggagu cggggacagc gcagaaaaau ggcacuggag      480

aauccgaaga ugcacaacag cgaaauaucu aaaagguugg gcgcugacug gaagcuccug      540

acagaugccg agaagcggcc uuuuaucgac gaggcuaaac gccugcgagc cguccauaug      600

aaggaauauc ccgauuacaa auauagacca aggcggaaga ccaaaacucu cuuaaagaag      660

gacaaauacu cccugccuuc aggccuuuug cccccagggg cagccgcugc ggcagccgcu      720

gccgcagccg cugccgcagc ggcuagcagu cccgugggag uuggucagcg ucuggauaca      780

uauacccacg ugaauggcug ggccaacggg gcauacucuc uaguccaaga gcagcucgga      840

uaugcccagc cuccauccau gagcucgccg cccccuccac ccgcucugcc uccaaugcau      900

cgcuacgaca uggccggccu ucaguacucu cccaugaugc cgccuggugc acaauccuau      960

augaaugugg cugccgcggc cgcugcagcc ucaggguacg gcggaauggc uccaagugcc     1020

acggcagcgg ccgcugccgc auauggccag cagcccgcua cugccgcagc cgcugcggcc     1080

gcagcugccg ccaugagccu ggggccuaug ggauccguag uuaagucuga acccagcuca     1140

ccaccucccg cuauugcaag ucacucccag agagccugcu ugggugaucu cagggacaug     1200

aucagcaugu accugccacc gggcggggau gcggcugacg ccgcaucucc uuuacccgga     1260

ggccggcugc acggugugca ucaacacuau cagggggccg gcaccgcugu caacggaaca     1320

gugccacuca cucauauuug a                                               1341


<210>  10048
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt4 from
       Sox3__Homo_sapiens__AAF73059

<400>  10048
augagacccg ugagagagaa cagcagcggc gccagaagcc ccagagugcc cgccgaccug       60

gccagaagca uccugaucag ccugcccuuc ccccccgaca gccuggccca cagacccccc      120

agcagcgccc ccaccgagag ccagggccug uucaccgugg ccgcccccgc ccccggcgcc      180

cccagccccc ccgccacccu ggcccaccug cugcccgccc ccgccaugua cagccugcug      240

gagaccgagc ugaagaaccc cgugggcacc cccacccagg ccgccggcac cggcggcccc      300

gccgcccccg gcggcgccgg caagagcagc gccaacgccg ccggcggcgc caacagcggc      360

ggcggcagca gcggcggcgc cagcggcggc ggcggcggca ccgaccagga cagagugaag      420

agacccauga acgccuucau gguguggagc agaggccaga gaagaaagau ggcccuggag      480

aaccccaaga ugcacaacag cgagaucagc aagagacugg gcgccgacug gaagcugcug      540

accgacgccg agaagagacc cuucaucgac gaggccaaga gacugagagc cgugcacaug      600

aaggaguacc ccgacuacaa guacagaccc agaagaaaga ccaagacccu gcugaagaag      660

gacaaguaca gccugcccag cggccugcug ccccccggcg ccgccgccgc cgccgccgcc      720

gccgccgccg ccgccgccgc cgccagcagc cccgugggcg ugggccagag acuggacacc      780

uacacccacg ugaacggcug ggccaacggc gccuacagcc uggugcagga gcagcugggc      840

uacgcccagc cccccagcau gagcagcccc cccccccccc ccgcccugcc ccccaugcac      900

agauacgaca uggccggccu gcaguacagc cccaugaugc cccccggcgc ccagagcuac      960

augaacgugg ccgccgccgc cgccgccgcc agcggcuacg gcggcauggc ccccagcgcc     1020

accgccgccg ccgccgccgc cuacggccag cagcccgcca ccgccgccgc cgccgccgcc     1080

gccgccgccg ccaugagccu gggccccaug ggcagcgugg ugaagagcga gcccagcagc     1140

cccccccccg ccaucgccag ccacagccag agagccugcc ugggcgaccu gagagacaug     1200

aucagcaugu accugccccc cggcggcgac gccgccgacg ccgccagccc ccugcccggc     1260

ggcagacugc acggcgugca ccagcacuac cagggcgccg gcaccgccgu gaacggcacc     1320

gugccccuga cccacaucug a                                               1341


<210>  10049
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt5 from
       Sox3__Homo_sapiens__AAF73059

<400>  10049
augagacccg ugcgggagaa cuccuccggc gcccgcucuc cuagaguccc ggcugaccug       60

gcccggagca uccucauuuc ccugcccuuc ccucccgauu cucuugcgca ccgcccuccc      120

agcuccgcuc cuaccgaauc ucaggggcug uuuacaguug ccgccccggc ucccggagcc      180

ccuagcccuc ccgcuacgcu cgcccaucug cuucccgcgc cggccaugua cucccugcuc      240

gagaccgaac ugaagaaucc ugugggcaca cccacccaag cugccgggac aggaggcccu      300

gcugcccccg ggggagcggg caaaagcucu gccaacgcug ccggcggggc uaauuccgga      360

ggcgggagcu cuggaggcgc cuccggggga ggcggcggga ccgaccagga uagagugaag      420

cggcccauga acgccuucau ggucuggagc cgcggacaga gacggaaaau ggcucuggag      480

aauccuaaga ugcacaacuc ugaaaucucc aaacgccucg gcgcggacug gaagcugcuu      540

acagaugccg agaagagacc guuuauugac gaggcuaaac ggcugcgcgc cgugcauaug      600

aaggaauauc ccgauuacaa auauagaccu cggcgcaaga ccaaaacgcu ccugaagaag      660

gacaaauaca gccuucccuc cgggcugcuc ccucccggag ccgcugccgc ggcugccgcc      720

gcugccgcug ccgcggccgc ugccucuagc ccgguuggcg uggggcagag acuggauacc      780

uauacacacg ucaauggaug ggcuaacggc gccuacuccc uggugcaaga gcagcucggc      840

uaugcgcagc cucccagcau gucuuccccu cccccucccc cggcccugcc ucccaugcau      900

cgguacgaca uggcugggcu ucaguacagc cccaugaugc cuccgggagc ccaaucuuau      960

augaauguug cugccgccgc ugcggccgcu agcggcuacg ggggaauggc ccccuccgcc     1020

accgcugccg cggcugccgc cuauggccag cagccugcua cagccgcggc ugccgccgcu     1080

gccgcugccg cgaugucucu ggggcccaug ggcagcgugg ucaaguccga accuagcucu     1140

cccccucccg ccaucgcuuc ccacagccag agagccugcc ucggagaucu gcgcgacaug     1200

auuucuaugu accuuccgcc uggcggggau gcugccgacg ccgcuagccc ccugccugga     1260

ggccggcucc acggggugca ucaacacuau cagggagcgg gcaccgccgu gaacgggacg     1320

gucccccuga cacauaucug a                                               1341


<210>  10050
<211>  1341
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  derived and/or modified sequence opt6 from
       Sox3__Homo_sapiens__AAF73059

<400>  10050
augagaccag uaagagaaaa uaguucuggu gcacguucac cuagaguacc agcagauuua       60

gcuagaucaa uacuuauuuc auuaccauuu ccaccagaua gccuagcaca ccgaccaccu      120

ucaucagcac cuacagaauc acaaggauua uuuacuguag cagcaccagc accaggagcu      180

ccaucacccc cagcuacacu agcacauuua cuaccagcac cagcaaugua uagccuacua      240

gaaacugaac uuaaaaaccc cguaggaaca cccacacaag cagcaggaac aggaggucca      300

gcagcaccag gaggagccgg aaaaucauca gcuaacgcag caggaggcgc caauucaggc      360

ggagguucuu caggaggugc auccggaggu ggaggaggca cagaccaaga uagaguaaaa      420

agaccaauga augcauucau gguauggagu agaggacaaa gaagaaaaau ggcacucgaa      480

aacccaaaaa ugcauaauag cgaaauauca aaaagguuag gagcagacug gaaauuauug      540

acagacgcag aaaaaagacc auuuauugau gaagcuaaaa gacuaagagc uguucauaug      600

aaagaauacc cugauuauaa auauagacca agaaggaaaa caaaaacauu auuaaaaaaa      660

gauaaauauu cauuaccuag uggauuauua ccaccaggug cagcagcagc agcagcagcc      720

gcagcagcag cagcugcagc ugcaucauca ccuguaggag uaggacaaag auuagauaca      780

uauacacaug uaaauggaug ggcaaauggc gcauauucau uaguacaaga acaauuagga      840

uacgcucaac caccaaguau gucaagccca ccuccuccac cagcauuacc accaaugcau      900

agauaugaua uggcuggauu acaauauagc ccaaugaugc cacccggugc ucaaucauau      960

augaauguag cagcagccgc agcagcagcu agcggauacg gcggaauggc uccuagugca     1020

acugcagcgg cagcagcagc guacggacaa caaccagcaa cagcagcagc ugcagcagca     1080

gcugcugccg caauguccuu aggaccgaug gguucaguag uaaaaucaga accaucaucu     1140

ccaccaccag caauagcauc acauucacaa agggcauguc uaggagauuu acgagauaug     1200

auaucaaugu aucuaccacc aggaggagau gcagcagaug cggcaucucc auuaccugga     1260

ggaagacuac auggaguuca ucaacauuac caaggagcag gaacagcagu aaauggaacu     1320

guaccacuaa cacacauaua a                                               1341


<210>  10051
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  5’-UTR of human ribosomal protein Large 32 lacking the 5’
       terminal oligopyrimidine tract

<400>  10051
ggcgcugccu acggaggugg cagccaucuc cuucucggca uc                          42


<210>  10052
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5’-UTR of human ribosomal protein Large 32 lacking the 5’
       terminal oligopyrimidine tract mRNA

<400>  10052
ggcgcugccu acggaggugg cagccaucuc cuucucggca uc                          42


<210>  10053
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  5’-UTR of human mitochondrial ATP synthase subunit alpha
       lacking the 5’ terminal oligopyrimidine tract

<400>  10053
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  10054
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  5’-UTR of human mitochondrial ATP synthase subunit alpha
       lacking the 5’ terminal oligopyrimidine tract mRNA

<400>  10054
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  10055
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, alpha 1 (HBA1)

<400>  10055
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccg uggucuuuga auaaagucug agugggcggc                 110


<210>  10056
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, alpha 1 (HBA1) mRNA

<400>  10056
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccg uggucuuuga auaaagucug agugggcggc                 110


<210>  10057
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, alpha 2 (HBA2)

<400>  10057
gcuggagccu cgguagccgu uccuccugcc cgcugggccu cccaacgggc ccuccucccc       60

uccuugcacc ggcccuuccu ggucuuugaa uaaagucuga gugggcag                   108


<210>  10058
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, alpha 2 (HBA2) mRNA

<400>  10058
gcuggagccu cgguagccgu uccuccugcc cgcugggccu cccaacgggc ccuccucccc       60

uccuugcacc ggcccuuccu ggucuuugaa uaaagucuga gugggcag                   108


<210>  10059
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, beta (HBB)

<400>  10059
gcucgcuuuc uugcugucca auuucuauua aagguuccuu uguucccuaa guccaacuac       60

uaaacugggg gauauuauga agggccuuga gcaucuggau ucugccuaau aaaaaacauu      120

uauuuucauu gc                                                          132


<210>  10060
<211>  132
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR of Homo sapiens hemoglobin, beta (HBB) mRNA

<400>  10060
gcucgcuuuc uugcugucca auuucuauua aagguuccuu uguucccuaa guccaacuac       60

uaaacugggg gauauuauga agggccuuga gcaucuggau ucugccuaau aaaaaacauu      120

uauuuucauu gc                                                          132


<210>  10061
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Center, alpha-complex-binding portion of the 3’UTR of an
       alpha-globin gene (muag)

<400>  10061
gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accg                        44


<210>  10062
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Center, alpha-complex-binding portion of the 3’UTR of an
       alpha-globin gene (muag) mRNA

<400>  10062
gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accg                        44


<210>  10063
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3´-UTR of human albumin

<400>  10063
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

aagcuuauuc aucuguuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaucu                                                                 186


<210>  10064
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3´-UTR of human albumin mRNA

<400>  10064
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

aagcuuauuc aucuguuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaucu                                                                 186


<210>  10065
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR albumin7

<400>  10065
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

uagcuuauuc aucucuuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaccu                                                                 186


<210>  10066
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3’-UTR albumin7 mRNA

<400>  10066
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

uagcuuauuc aucucuuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaccu                                                                 186


<210>  10067
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3´-UTR ALB7

<400>  10067
gcaucacauu uaaaagcauc ucagccuacc augagaauaa gagaaagaaa augaagauca       60

auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag ccaacacccu gucuaaaaaa      120

cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu ucaauuaaua aaaaauggaa      180

agaaccu                                                                187


<210>  10068
<211>  187
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  3´-UTR ALB7 mRNA

<400>  10068
gcaucacauu uaaaagcauc ucagccuacc augagaauaa gagaaagaaa augaagauca       60

auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag ccaacacccu gucuaaaaaa      120

cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu ucaauuaaua aaaaauggaa      180

agaaccu                                                                187


<210>  10069
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  histone stem-loop sequence 

<400>  10069
caaaggcucu uuucagagcc acca                                              24


<210>  10070
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  histone stem-loop sequence mRNA

<400>  10070
caaaggcucu uuucagagcc acca                                              24


<210>  10071
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Kozak

<400>  10071
gccgccacca ugg                                                          13


